bluuebunny/crossref_metadata_2025_split huggingface dataset:
Missing the forest because of the trees: Slower alternations during binocular rivalry are associated with lower levels of visual detail during ongoing thought
Authors: Ho Nerissa Siu Ping , Baker Daniel , Karapanagiotidis Theo , Seli Paul , Wang Hao Ting , Leech Robert , Bernhardt Boris , Margulies Daniel , Jefferies Elizabeth , Smallwood Jonathan 
Published: January 2020

AbstractConscious awareness of the world fluctuates, either through variation in the quality with which we perceive the environment, or, when attention switches to information generated using imagination rather than the external environment. Our study combined individual differences in experience sampling, psychophysical reports of perception, and neuroimaging descriptions of structural connectivity, to better understand these changes in conscious awareness. In particular, we (a) examined if aspects of ongoing thought, as measured by multi-dimensional experience sampling during a sustained attention task, are associated with the white matter fibre organization of the cortex as reflected by their relative degree of anisotropic diffusion, and (b) whether these neuro-cognitive descriptions of ongoing experience are related to a more constrained measure of visual consciousness provided by the analysis of bistable perception during binocular rivalry. Individuals with greater fractional anisotropy (FA) in right hemisphere white matter regions involving the inferior fronto-occipital fasciculus, the superior longitudinal fasciculus and the cortico-spinal tract, described their ongoing thoughts as lacking external details. Subsequent analysis indicated that the combination of low FA in these right hemisphere regions, with reports of high level external details, was associated with the shortest periods of dominance during binocular rivalry. Since variation in binocular rivalry reflects differences between bottom-up and top-down influences on vision, our study suggests that reports of ongoing thoughts with vivid external details may occur when conscious precedence is given to bottom-up representation of perceptual information and that this may partly be rooted in the white matter fibre organization of the cortex.
Rotavirus Induces Intercellular Calcium Waves through ADP Signaling
Authors: Chang-Graham Alexandra L. , Perry Jacob L. , Engevik Melinda A. , Danhof Heather A. , Scribano Francesca J. , Engevik Kristen A. , Nelson Joel C. , Kellen Joseph S. , Strtak Alicia C. , Sastri Narayan P. , Estes Mary K. , Versalovic James , Britton Robert A. , Hyser Joseph M. 
Published: January 2020

AbstractRotavirus causes severe diarrheal disease in children by broadly dysregulating intestinal homeostasis. However, the underlying mechanism(s) of rotavirus-induced dysregulation remains incompletely characterized. Here we show that rotavirus-infected cells produce paracrine signals that manifest as intercellular calcium waves (ICWs); which are observed in both cell lines and human intestinal enteroids. Rotavirus ICWs are caused by the release of extracellular adenosine diphosphate (ADP) that activates P2Y1 purinergic receptors on neighboring cells and are blocked by P2Y1 antagonists or CRISPR/Cas9 knockout of P2Y1. Blocking the paracrine ADP signal reduces rotavirus replication, inhibits rotavirus-induced serotonin release and fluid secretion, and reduces diarrhea severity in neonatal mice. This is the first evidence that viruses exploit ICWs to amplify diarrheal signaling; a finding which has broad implications for gastrointestinal physiology.SummaryRotavirus triggers the extracellular release of ADP from infected cells to dysregulate nearby uninfected cells and activate pro-disease pathways.
Sex differences in central inflammatory pain sensitization are associated with differential expression of glycine receptors and GLP-1 at the spinal cord
Authors: Mariqueo TA. , Améstica G. , Pino J. , Barra R. , Stehberg J. , González W. , Castillo K. 
Published: January 2020

AbstractBackgroundFemales have higher inflammatory pain representation. However, sex differences in central pain sensitization and the regulation of nociceptive response to peripheral inflammation remain unclear. The central pain sensitization is mediated by inhibitory neurotransmission and glial cell activity dysregulation where spinal glycine and GLP-1 receptors have described play a critical role.ObjectivesThe aim of this study was to compare the mechanical withdrawal nociceptive threshold with spinal glycine receptor subunits and GLP-1 expression in adult male and female rats after inflammatory hypersensitivity.MethodsSex differences in inflammatory nociception were evaluated before and after intraplantar hindpaw Zymosan A injection in Sprague-Dawley rats. Mechanical paw withdrawal thresholds were tested using von Frey filaments.Western blot was used to measure GlyRs subunits protein levels in the spinal cord. GLP-1 was determined using the Magnetic Luminex Assay.ResultsA reduced nociceptive threshold was observed in males and females rats after 4 hours of inflammatory Zymosan A injection. However, this reduction was significantly major in females. Western blot analysis demonstrated significantly increased α1, α2, α3 and β GlyR subunit levels in male rats. Female rats only increased α3 and β GlyR subunits after Zymosan A injection. GLP-1 was reduced in female spinal tissues after an inflammatory injury.ConclusionsOur study indicates that sex differences in nociceptive threshold after inflammatory Zymosan A rat pain sensitization is related to the sex differences in glycine receptor subunits and GLP-1 expression at the spinal cord.
Viscous medium-based crystal support in sample holder for fixed-target serial femtosecond crystallography
Authors: Lee Keondo , Lee Donghyeon , Baek Sangwon , Park Jaehyun , Lee Sang Jae , Park Sehan , Chung Wan Kyun , Lee Jong-Lam , Cho Hyun-Soo , Cho Yunje , Nam Ki Hyun 
Published: January 2020

AbstractSerial femtosecond crystallography (SFX) enables the determination of a room-temperature crystal structure of macromolecules without causing radiation damage, as well as provides time-resolved molecular dynamics data in pump-probe experiments. Fixed-target SFX (FT-SFX) can minimize sample consumption and physical effects to crystals during sample delivery. Various types of sample holders have been developed and applied in FT-SFX; however, no sample holder has been developed that can universally mount crystals of various sizes and shapes. Here, we introduce a viscous media-based crystal support in a sample holder for FT-SFX. Crystal samples were embedded in viscous media such as gelatin and agarose, which were enclosed in a polyimide film. In the vertically placed sample holder, the viscous medium stably supported crystals between the two polyimide films without crystal sinking due to gravity. Using this method, we performed FT-SFX experiments with glucose isomerase and lysozyme embedded in gelatin and agarose, respectively. The room-temperature crystal structures of glucose isomerase and lysozyme were successfully determined at 1.75 and 1.80 Å resolutions, respectively. Viscous media used in this experiment showed negligible background scattering in data processing. This method is useful for delivering crystal samples of various sizes and shapes in FT-SFX experiments.
Taxing land rent, lowering other taxes – the case of Hong Kong
Authors: Ho Lok Sang , Wong Gary Wai Chung 
Published: January 2020

Purpose
The purpose of this paper is threefold: to study if Hong Kong’s fiscal revenue is closely related to land rent; to assess if a fiscal regime relying on taxing land rent is good for the economy; and to explore if Hong Kong adopts a high land price policy.

Design/methodology/approach
In this paper, first, theoretical and conceptual exploration into the Henry George Theorem is made to investigate if a single tax regime is conceptually feasible. Second, time series econometric study investigates into the determinants of Hong Kong’s fiscal revenue and Hong Kong’s public expenditures. Granger causality tests are conducted to study the direction of causality.

Findings
Hong Kong does not have a high land price policy; it uses a multipronged approach to tax land rent, which cannot be precisely identified; its low tax regime is good for the economy and contributes to a virtuous circle: taxing land rent, low taxes, vigorous economy, higher land rent and low taxes.

Originality/value
This study uses a familiar methodology on a subject on a policy area that has not been studied before.
Benchmarking company performance from economic and environmental perspectives
Authors: Zeng Qinqin , Beelaerts van Blokland Wouter , Santema Sicco , Lodewijks Gabriel 
Published: January 2020

Purpose
The purpose of this paper is to develop an approach to measuring the performance of motor vehicle manufacturers (MVMs) from economic and environmental (E&E) perspectives.

Design/methodology/approach
Eight measures are identified for benchmarking the performance from E&E perspectives. A new company performance index IMVM is constructed to quantitatively generate the historical data of MVMs’ company performance. Autoregressive integrated moving average (ARIMA) models are built to generate the forecast data of the IMVM. The minimum Akaike information criteria value is used to identify the model of the best fit. Forecast accuracy of the ARIMA models is tested by the mean absolute percentage error.

Findings
The construction of the index IMVM is benchmarked against three frameworks by six benchmark metrics. The IMVM satisfies all of its applicable metrics while the three frameworks are incapable to satisfy their applicable metrics. Out of 15, 4 MVMs are excluded for benchmarking future performance due to their non-stationary time series data. Based on the forecast IMVM data, GM is the best performer among the 15 samples in the FY2018.

Originality/value
This research highlights the environmental perspective during vehicles’ production. The development of this approach is based on publicly available data and transparent about the methods it used. The data out of the approach can benefit stakeholders with insights by benchmarking the historical performance of MVMs as well as their future performance.
Constructive (mis)alignment in team-based experiential entrepreneurship education
Authors: Scott Jonathan Matthew , Pavlovich Kathryn , Thompson John L. , Penaluna Andy 
Published: January 2020

Purpose
Little is known about how experiential entrepreneurship education approaches contribute toward enhancing the engagement of students in the learning process. Using a purposive and convenience sample of individual student reflective journals, the purpose of this paper is to critically evaluate how the process of constructive misalignment enhances the level of student engagement through a team-based experiential entrepreneurship education assessment.

Design/methodology/approach
Data were gathered from a purposive and convenience sample of reflective journals, an individual “performance assessment” element of three Masters-level courses (courses 1, 2 and 3) that included an “active” group business ideas generation presentation and a report. These texts were analyzed through content analysis that critically evaluates and summarizes the content of data and their messages.

Findings
While expected learning outcomes included teamwork and communication, the higher levels of active learning and student engagement related to innovation and generating a business idea was much more modest. Rather, the study finds that significant learning opportunities were apparent when students experienced unexpected aspects of constructive misalignment, such as linguistic–cultural challenges, nonparticipation and freeriding.

Originality/value
Building on Biggs’ (2003) model of constructive alignment in course design and delivery/assessment, this paper elucidates various unexpected and surprising aspects. It suggests that constructive misalignment could provide major learning opportunities for students and is thus more likely in these team contexts where entrepreneurship students experience constructive misalignment. Educators should, therefore, continue to design experiential entrepreneurship courses and their performance assessments through team-based approaches that achieve higher levels of engagement as well as more active learning.
Australian graduates’ work readiness – deficiencies, causes and potential solutions
Authors: Prikshat Verma , Montague Alan , Connell Julia , Burgess John 
Published: January 2020

Purpose
It is widely reported that there is a competence deficit between graduating from Australian higher education (HE) and becoming work ready and that the deficit is becoming more pronounced. The purpose of this paper is to examine the work readiness competencies of Australian HE and vocational education (VE) graduates. The reported competence deficits, the causes of these deficits and the potential strategies to overcome these deficits are discussed.

Design/methodology/approach
A qualitative, inductive research design was used to examine Australian graduates’ work readiness competence, potential deficits, their causes and possible solutions to gain some preliminary insights and help shape future research. A multiple case design was used comprising key stakeholders’ in-depth interviews and focus group discussions. In-depth semi-structured interviews and focus group discussions were conducted to gain insights from the key stakeholders.

Findings
The stakeholders reported that the Australian VE and HE sectors do not sufficiently prepare graduates in terms of their work readiness skills. Self-management skills, communication (written and expression), team-work skills, cognitive skills, system thinking and innovation and creativity were the main work readiness competency deficits reported by the stakeholders.

Research limitations/implications
The research has its limitations in terms of the limited sample and time frame, and the absence of input from graduates. The results of the study indicate the deteriorating state of the Australian graduate labour market and emphasise that an integrated approach is urgently required from all stakeholders to facilitate the transition and reduce the time taken from graduation to employment.

Originality/value
The focus of the study is located in the Australian labour market in terms of the competencies that reportedly are present upon graduation and the competencies that employers are looking for on recruitment. The requisite competency list and the deficits are examined through the lens of four stakeholder groups; government representatives, industry representatives and VE and HE representatives.
Enhancing human capital beyond university boundaries
Authors: Jakubik Maria 
Published: January 2020

PurposeThe purpose of this paper is to present a case about the emergence of human capital (HC) during the master thesis as a work-based learning project.Design/methodology/approachThe case study uses data from 107 master’s students 2007–2011 and feedback from 91 managers as business advisors 2007–2016.FindingsThe findings show direct contributions of higher education (HE) to intellectual capital (IC) in organisations through the enhanced HC of managers.Originality/valueThe case contributes to the emerging new, fifth stage of IC research by demonstrating how HC develops beyond the boundaries of an educational institution; how it influences an organisation’s IC and how 91 business advisors, as external stakeholders, assessed the achievements and value creation of HE.
Identification of key employability attributes and evaluation of university graduates’ performance
Authors: Abbas Jawad , Sagsan Mustafa 
Published: January 2020

PurposeThe purpose of this paper is to investigate the managers’ views on the characteristics which university graduates should have to obtain the job and efficiently perform in Chinese industrial organizations, and how are they performing in the industry.Design/methodology/approachMix-method approach was followed to identify the key employability attributes, employers’ expectations and students’ performance. Analysis of interviews and literature provided the foundation for the development of the employability instrument used. In total, 11 identified attributes were grouped into four dimensions, i.e. knowledge, skills, abilities and professional attitude. Structural analysis was performed to test the hypotheses and theoretical model. The importance of the identified attributes was checked via the ranking technique, followed by an evaluation of students’ actual performance and a comparison between them.FindingsEmpirical analyses indicate that the managers in China consider “skills” as the most important dimension for employability in Chinese industrial organizations and “reliability” is the highly demanded subsequent factor. A significant gap has been found in all studied dimensions and 10 out of 11 sub-factors.Originality/valueThis study not only identifies key employability attributes, but also proposes and validates an instrument for measuring students’ industrial performance. It also highlights the factors where industry and academia should focus to improve graduates’ employability and their industrial performance.
Competencies associated with Semestre i and its relationship to academic performance
Authors: Lozano-Rodríguez Armando , García-Vázquez Fernanda Inéz , Zubieta-Ramírez Claudia , Lopez-Cruz Claudia Susana 
Published: January 2020

PurposeCurrently, higher education institutions are in charge of the complex task of connecting the knowledge that students acquire in the classroom to the requirements of the working world, preparing the students to face complex situations inherent in professional life. For this reason, the Tecnológico de Monterrey has included as part of the training of its students the modality, Semestre i, sustained through the teaching methodology of challenge-based learning. Recognizing this new way of learning, the purpose of this paper is to address the study of four basic constructs: student engagement, teacher–student relationship, teamwork and time management.Design/methodology/approachAn exploratory factor analysis was performed on the factors associated with the Semestre i, as well as a correlational analysis between these and the academic achievement of the students in the 2017 August–December period.FindingsThe results indicate that the four constructs analyzed were potentialized under the modality, Semestre i – time management showing the least difference of the four when compared with the educational experience of students being traditionally taught throughout their semesters.Originality/valueSemestre i is an innovative educational proposal where the undergraduate students learn in immersive, real-world contexts by experiencing semester challenges planned for them by the teaching body of the institution. Recognizing this new way of learning, this research addresses the study of four basic constructs: student engagement, teacher–student relationship, teamwork and time management.
Numerical investigation of frequency-amplitude effects of dynamic morphing for a high-lift configuration at high Reynolds number
Authors: Marouf Abderahmane , Bmegaptche Tekap Yannick , Simiriotis Nikolaos , Tô Jean-Baptiste , Rouchon Jean-François , Hoarau Yannick , Braza Marianna 
Published: January 2020

Purpose
The purpose of this study illustrates the morphing effects around a large-scale high-lift configuration of the Airbus A320 with two elements airfoil-flap in the take-off position. The flow around the airfoil-flap and the near wake are analysed in the static case and under time-dependent vibration of the flap trailing-edge known as the dynamic morphing.

Design/methodology/approach
Experimental results obtained in the subsonic wind tunnel S1 of Institut de Mécanique des Fluides de Toulouse of a single wing are discussed with high-fidelity numerical results obtained by using the Navier–Stokes multi-block (NSMB) code with advanced turbulent modelling able to capture the predominant instabilities and coherent structure dynamics. An explanation of the dynamic time-dependent grid deformation is provided, which is used in the NSMB code to simulate the flap’s trailing-edge deformation in the morphing configuration. Finally, power spectral density is performed to reveal the coherent wake structures and their modification because of the morphing.

Findings
Frequency of vibration and amplitude of deformation effects are investigated for different morphing cases. Optimal morphing regions at a specific frequency and a slight deformation were able to attenuate the predominant natural shear-layer frequency and to considerably decrease the width of the von Kármán vortices with a simultaneous increase of aerodynamic performances.

Originality/value
The new concept of future morphed wings is proposed for a large scale A320 prototype at the take-off position. The dynamic morphing of the flap’s trailing-edge is simulated for the first time for high-lift two-element configuration. In addition, the wake analysis performed helped to show the turbulent structures according to the organised eddy simulation model.
Thermal response of cylindrical tissue induced by laser irradiation with experimental study
Authors: Hobiny Aatef , Abbas Ibrahim 
Published: January 2020

Purpose
The purpose of this paper is to provide a method for determining the numerical solutions of the thermal damage of cylindrical living tissues using hyperbolic bioheat model. Due to the complex governing equation, the finite element approach has been adopted to solve these problems. To approve the accuracy of the numerical solution, the numerical outcomes obtained by the finite element approach are compared with the existing experimental study. In addition, the comparisons between the numerical outcomes and the existing experimental data displays that the present mathematical models are efficient tools to evaluate the bioheat transfer in the cylindrical living tissue. Numerical computations for temperatures and thermal damage are presented graphically.

Design/methodology/approach
In this section, the complex equation of bioheat transfer based upon one relaxation time in cylindrical living tissue is summarized by using the finite element method. This method has been used here to get the solution of equation (8) with initial conditions (9) and boundary conditions (10). The finite element technique is a strong method originally advanced for numerical solutions of complex problems in many fields, and it is the approach of choice for complex systems. Another advantage of this method is that it makes it possible to visualize and quantify the physical effects independently of the experimental limits. Abbas and his colleagues [26-34] have solved several problems under generalized thermoelastic theories.

Findings
In this study, the different values of blood perfusion and thermal relaxation time of the dermal part of cylindrical living tissue are used. To verify the accuracy of the numerical solutions, the numerical outcomes obtained by the finite element procedure and the existing experimental study have been compared. This comparison displays that the present mathematical model is an effective tool to evaluate the bioheat transfer in the living tissue.

Originality/value
The validation of the obtained results by using experimental data the numerical solution of hyperbolic bioheat equation is presented. Due to the nonlinearity of the basic equation, the finite element approach is adopted. The effects of thermal relaxation times on the thermal damage and temperature are studied.