bluuebunny/crossref_metadata_2025_split huggingface dataset:
P61 Comparison of Two Oscillometric Technics for Measuring Pulse Wave Velocity
Authors: Benczúr Béla , Bocskei Renata , Cziraki Attila 
Published: March 2020

AbstractIt has been proven that aortic pulse wave velocity (aoPWV), the measure of arterial stiffness is a strong and independent predictor of both cardiovascular events and all-cause mortality. Beyond the “gold standard” cfPWV (carotid-femoral) a plenty of methods are available for measuring PWV but the interpretation of their results are problematic and not interchangeable.
Patients and Methods
Our aim was to assess the association and agreement of two oscillometric methods; the upper armcuffed invasively validated Arteriograph system and the brachial-ankle PWV (baPVW) measurement employed by the automatic BOSO-ABI system which operates simultaneous cuff-measurements on both extremities. 157 apparently healthy individuals of both sexes (mean age was 44.3 + 9.3 ys; 54 male and 103 female) were examined in this study.

Results
Mean PWV was significantly higher with BOSO (11.76 + 1.52 m/s) than Arteriograph (8.45 + 1.71 m/s). The two different measurement modalities demonstrated moderate linear correlation (The Pearson’s test of correlation coefficient r = 0.391, p < 0.001). The lack of agreement between the two methods is confirmed also by the Bland-Altman plot.

Conclusion
Both methods are simple and easy to use and offer a user independent automatic assessment of PWV. The difference of the measured values derived from the different path length the two methods use.
P81 Antibody to Cardiotonic Steroid Reduces Blood Pressure and Vascular Fibrosis in Preeclampsia
Authors: Agalakova NI , Reznik VA , Nadei OV , Ershov IA , Rassokha OS , Vasyutina ML , Galagudza MM , Bagrov AY 
Published: March 2020

Abstract
Background
Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). We demonstrated that MBG induces fibrosis via mechanism involving inhibition of Fli1, a nuclear transcription factor and a negative regulator of collagen-1 synthesis.

Objectives and Methods
We hypothesized that PE blockade of increased MBG with antibody would lessen the fibrosis of umbilical arteries and lower the blood pressure in rats with PE. We tested 36 pregnant Sprague-Dawley rats in which 12 were made hypertensive by 1.8% Na supplementation (days 6–19 of gestation), 12 pregnant rats served controls. At day 19, PE rats received one intraperitoneal injection of polyclonal anti-MBG-4 antibody (0.5 ug/mL) for 4 hours.

Results
PE was associated with higher blood pressure (117 ± 2 vs 107 ± 2 mmHg; p < 0.01), plasma MBG levels (1.54 ± 0.34 vs 0.49 ± 0.11 nmol/L; p < 0.01), protein excretion (26 vs 12 mg/24 hours), sFlt-1 (4-fold), decrease in Fli1 (7-fold) and increase in collagen-1 in aorta (4-fold) vs. control rats (all p < 0.01). In 12 rats was treated with polyclonal anti-MBG-4 antibody blood pressure dropped (93 ± 3 mmHg) and Fli1 was decreased much less (2-fold; p < 0.01 vs nontreated rats).

Conclusion
These results demonstrate that in experimental PE elevated MBG level is implicated in umbilical fibrosis via suppression of Fli1. Supported by Russian Scientific Foundation grant № 18-15-00222.
P86 Can Central Blood Pressure be Accurately Estimated in Individuals with and Without Systolic Blood Pressure Amplification?
Authors: Goupil Remi , Kowalski Cédric , Lamarche Florence 
Published: March 2020

Abstract
Introduction
Systolic blood pressure (SBP) does not always amplify from central to peripheral arteries. Individuals without SBP amplification (SBPamp) have higher aortic blood pressure (BP) despite similar brachial cuff SBP. To circumvent this discrepancy, the aim of this study was to determine if aortic SBP can be accurately estimated non-invasively in patients with and without SBPamp.

Methods
Patients undergoing percutaneous coronary intervention were recruited. Individuals with atrial fibrillation, ≥10 mmHg between-arm SBP difference or severe aortic stenosis were excluded. Aortic and brachial intra-arterial BP were measured using a fluid-filled catheter. Simultaneously, brachial and central cuff BP were measured in triplicate (Mobil-o-Graph, IEM, Germany). Central BP was estimated by pulse wave analysis with Type I (SBP and diastolic BP) and Type II (mean and diastolic BP) calibrations. Aortic-to-brachial SBPamp was defined as ≥5 mmHg increase between intra-arterial aortic and brachial SBP.

Results
Of the 151 patients recruited, only 85 had SBPamp. SBPamp+ and SBPamp- patients had similar brachial cuff SBP (126 +/− 15 vs 126 +/− 16 mmHg, p = 0.8) and clinical characteristics, apart from lower augmentation index in SBPamp+ (18 +/− 10 vs 22 +/− 11, p = 0.03). Central BP estimated with Type I or Type II calibration could not accurately determine aortic SBPs in both phenotypes (Table 1). Using the mean of both estimates only provided a slightly better accuracy.

Conclusion
Central BP measurements cannot accurately identify the different aortic BP of the SBPamp phenotypes. A new central BP calibration may be needed to circumvent this problem.

Table 1

Baseline characteristics
SBPamp+ (n = 85)
SBPamp− (n = 66)
p-value

Male sex
74%
74%
1.0

Age
66 ± 11
65 ± 9
0.6

Height (cm)
171 ± 10
170 ± 10
0.6

BMI (kg/m2)
29 ± 6
30 ± 10
0.3

Active smoking
28%
27%
0.9

Diabetes
19%
17%
0.7

Hypertension
59%
55%
0.6

Dyslipidemia
55%
55%
0.9

Prior cardiovascular disease
39%
52%
0.1

eGFR (mL/min/1.73 m2)
80 ± 18
81 ± 18
0.7

Brachial cuff SBP
126 ± 15
126 ± 16
0.8

Brachial cuff diastolic blood pressure
78 ± 9
78 ± 12
0.9

Heart rate (bpm)
67 ± 11
65 ± 11
0.3

Augmentation index @ 75 bmp
18 ± 10
22 ± 11
0.03

Pulse wave velocity (m/s)
10 ± 2
9 ± 2
0.09

SBPamp+ and SBPamp− denotes individuals with and without SBP amplification, defined as ≥5 mmHg increase between intra-arterial aortic and brachial SBP. Values are expressed as mean ± standard deviation. All blood pressure measures are expressed in mmHg. p-values are calculated using Pearson’s chi-square and Student t-tests. SBP, systolic blood pressure.
P88 Improvement in Functional Capacity with Spironolactone Masks the Treatment Effect on Exercise Blood Pressure
Authors: Moore Myles , Schultz Martin , Hare James , Marwick Thomas , Sharman James 
Published: March 2020

Abstract
Background
A hypertensive response to submaximal exercise is associated with cardiovascular disease but may be influenced by functional capacity. Spironolactone may improve functional capacity, which could mask treatment effects on exercise blood pressure (BP). This study sought to examine this hypothesis.

Methods
This was a retrospective analysis of clinical trial data in 102 participants (54 ± 9 years; 52% male) with a hypertensive BP response to peak exercise (systolic BP ≥210 mmHg in men; ≥190 mmHg in women) who were randomised to 3-months spironolactone 25 mg daily (n = 53) or placebo control (n = 49). Submaximal exercise BP was measured during fixed low-intensity cycling (50–70% maximal age-predicted heart rate). Functional capacity was measured as maximal oxygen capacity obtained during a separate maximal treadmill exercise test.

Results
Spironolactone improved submaximal exercise systolic BP with a small effect size compared to placebo (−4 ± 16 vs 2 ± 15 mmHg, p = 0.08, Cohen’s d = 0.35), but also functional capacity with a small effect size (0.64 ± 5.10 vs −1.43 ± 5.04 ml/kg/min, p = 0.06, Cohen’s d = 0.41). However, when the change in submaximal exercise systolic BP was expressed relative to the change in functional capacity, there was a significant decrease with spironolactone compared to placebo (−0.3 ± 1.1 vs 0.3 ± 1.1 mmHg/ml.kg.min−1, p = 0.01, Cohen’s d = 0.54).

Conclusion
Spironolactone may reduce submaximal exercise BP, but its full treatment effects may be hidden by increased functional capacity. A change in exercise BP should be interpreted according to any change in functional capacity.
P135 Assessment of Novel Blood Pressure Corrected Cardio-ankle Vascular Index in Response to Acute Blood Pressure Changes
Authors: Mestanik Michal , Spronck Bart , Jurko Alexander , Mestanikova Andrea , Jurko Tomas , Butlin Mark , Avolio Alberto , Olexova Lucia Bona , Visnovcova Zuzana , Sekaninova Nikola , Tonhajzerova Ingrid 
Published: March 2020

Abstract
Background
Cardio-ankle vascular index (CAVI) has long been considered a measure of arterial stiffness independent of short-term changes in blood pressure (BP) [1]. Recently and theoretically, CAVI was found to be partially affected by actual BP, thus, a novel BP-corrected index, CAVI0, was proposed to diminish these effects [2,3]. Direct, repeated measures experimental data comparing CAVI’s and CAVI0’s acute blood pressure dependence is lacking. Hence, the aim of this study was to assess the effects of short-term changes of BP on CAVI0 in comparison with standard CAVI.

Methods
60 healthy adults were examined using vascular screening system VaSera 1500 N (Fukuda Denshi Co., Tokyo, Japan) during four examination periods lasting 5 minutes — baseline, cold pressor test (CPT), recovery period, and isometric handgrip exercise (IHE). CAVI and cardiovascular parameters for calculation of CAVI0 were measured after baseline, at the peak of pressor response to CPT, after recovery period, and at the peak of pressor response to IHE. CAVI, CAVI0, and mean BP were assessed for all periods.

Results
CAVI significantly increased during CPT compared to baseline rest (p = 0.008), returned to baseline values during recovery period (p = 0.011 compared to CPT), and significantly increased during IHE compared to recovery period (p = 0.002). No significant changes of CAVI0 were found. CAVI significantly correlated with changes in mean BP (p = 0.012; multilevel regression); CAVI0 did not (p = 0.570).

Conclusion
In this repeated measures, experimental, acute study, CAVI showed short-term blood pressure dependence, whereas CAVI0 did not.
P144 Augmentation Index is not a Reliable Measure of Wave Reflections in Patients with Severe Aortic Stenosis
Authors: Pagoulatou Stamatia , Stergiopulos Nikolaos , Bikia Vasiliki , Rovas Georgios , Müller Hajo , Noble Stéphane , Adamopoulos Dionysios 
Published: March 2020

Abstract
Background
Augmentation index (AIx) serves as an independent predictor of cardiovascular events and mortality. It is often clinically used as a measure of arterial stiffness and reflections, a practice that was recently challenged. In this work, we sought to investigate the association between AIx and wave reflections in patients with severe aortic stenosis.

Methods
The final cohort comprised of 18 subjects (86 ± 4 years, 28% males) with severe aortic stenosis who underwent a Transcatheter Aortic Valve Implantation (TAVI). Invasive aortic and left ventricular pressure waveforms were obtained simultaneously before and after the TAVI. Key pressure waveform features were extracted and wave separation analysis was performed by combining aortic pressure and flow (Doppler echocardiography) data before and after the valve replacement.

Results
After the TAVI, aortic SBP and maximal blood flow velocity increased (from 134 ± 22 to 151 ± 30 mmHg, p = 0.04 and from 298 ± 65 to 376 ± 81 mL/sec, p < 0.01 respectively), while the ejection duration decreased (from 0.42 ± 0.07 to 0.35 ± 0.06 sec, p < 0.01). A significant decrease in AIx and augmented pressure was noted (from 44 ± 16 to 17 ± 12% and from 34 ± 13 to 17 ± 14 mmHg respectively, p < 0.01 for all). Wave separation analysis however showed a comparable increase in both forward (from 61 ± 14 to 79 ± 22 mmHg, p < 0.01) and backward (from 31 ± 11 to 39 ± 12 mmHg, p < 0.05) wave amplitudes. Reflection magnitude and backward wave transit time remained unchanged (p = NS).

Conclusion
Decrease in AIx after TAVI is not associated with changes in wave reflection amplitude or timing. For patients with severe aortic stenosis, interpretation of AIx should be done with caution.
Pendampingan Pembuatan Mural Sebagai Upaya Perbaikan Visual Kawasan Loa Buah, Samarinda
Authors: Noviana Mafazah , Thamrin Nur Husniah 
Published: March 2020

ABSTRAK Salah satu upaya yang dapat dilakukan untuk memperbaiki kualitas visual sebuah kawasan adalah dengan seni mural. Selain dianggap memperindah tampilan kawasan, keberadaan gambar-gambar dan warna ini juga dapat memperkuat karakter sebuah kawasan. Panti Asuhan Baitul Walad merupakan salah satu panti asuhan yang terletak di Kelurahan Loa Buah. Panti asuhan ini mempunyai misi menolong anak-anak yatim atau yang tidak mampu yang berpotensi untuk memperoleh pendidikan yang baik. Sebagai bekal untuk menghadapi kehidupan di masa depan, anak-anak asuh panti harus banyak memperoleh bekal keterampilan salah satunya adalah pelatihan dan pendampingan membuat mural. Khalayak sasaran program ini adalah anak asuh Panti Asuhan Baitul Walad. Metode yang dilakukan adalah dengan metode ceramah, praktik dengan bimbingan, serta evaluasi. Dalam kegiatan pelatihan dan ini tahap-tahap yang lakukan adalah memberi materi pendahuluan, tahap persiapan pembuatan mural, tahap melukis dan tahap finishing. Pelaksanaan kegiatan ini berjalan dengan baik sesuai dengan yang direncanakan, peserta antusias mengikuti kegiatan dan memberi respon yang positif. Kegiatan pengabdian masyarakat berupa pembuatan mural ini memberi keterampilan baru bagi peserta yaitu anak asuh Panti Asuhan Baitul Walad sekaligus secara umum memperbaiki aspek estetika visual Kawasan Loa Buah Kota Samarinda. Kata Kunci: loa buah; mural; pelatihan; pendampingan.ABSTRACT One effort that can be done to improve the visual quality of an area is with mural art. Besides being considered to beautify the appearance of the region, the presence of images and colors can also strengthen the character of an area. Baitul Walad Orphanage is one of the orphanages located in the Village of Loa Buah. This orphanage has a mission to help orphans or underprivileged people who have the potential to get a good education. As a provision to face life in the future, orphanage children have to get a lot of skills, one of which is training and assistance in making murals. The target audience for the program is the foster children of the Baitul Walad Orphanage. The method used is the lecture method, practice with guidance, and evaluation. In the training activities and the stages, the steps taken are to provide preliminary material, the preparation stage for mural, the painting stage and the finishing stage. The implementation of this activity went well as planned, participants enthusiastically participated in the activity and gave a positive response. The community service activity in the form of making murals gave new skills to participants, the foster children of the Baitul Walad Orphanage, while at the same time improving the visual aesthetic aspects of the Loa Buah Samarinda City.Keywords: accompaniment; loa buah; mural; training.
¿Qué se entiende por juego didáctico? Aportaciones de maestros y estudiantes en prácticas sobre su concepción como elemento fundamental en el desarrollo del proceso enseñanza-aprendizaje
Authors: Higueras-Rodríguez Lina , Molina-Ruíz Enriqueta 
Published: March 2020

El uso de herramientas innovadoras es un elemento clave en la mejora del proceso educativo, y consecuentemente, la utilización del juego didáctico puede ser una gran herramienta para mejorar no solo el aprendizaje de los alumnos, sino también para mejorar las expectativas del maestro. Por ello, esta investigación tratamos de indagar qué entienden tanto maestros como estudiantes en prácticas sobre juego didáctico. Partiendo de una metodología cualitativa, abordamos un estudio descriptivo-interpretativo de la información a partir de 31 entrevistas realizadas tanto a maestros de Educación Primaria como a estudiantes que se encuentran en período de prácticas y en su último año de su formación inicial. Los resultados indican que aunque cada uno lo categorice con una noción diferente, es decir, como recurso, reto, actividades, herramientas, concepto, etc. la finalidad es la misma para todos, es decir, buscan el aprendizaje a través de este, teniendo en cuenta la dimensión lúdica. Además, de abarcar todas las dimensiones del alumno para que aprendizaje llegue a ser integral a través de elementos innovadores.
Performanz – Emergenz
Authors: Küpper Joachim 
Published: February 2020

Abstract
Following John L. Austin’s How to Do Things With Words (1962), it has become a widely accepted view, particularly in literary and textual studies, that the articulation of linguistic signs (vulgo: words) can change reality or even produce ‘new’ realities. This article problematizes the tenability of Austin’s basic assumptions; it submits for consideration that speech acts are only effective if they are instantiations of a previous consensus establishing their validity. The reversal of the Aristotelian hierarchy of intention and act, which is implied in Austin’s views, seems to be based rather on rhetoric than on logic. In its second section, the paper discusses some aspects of the ‘performative turn’ in the Humanities, as initiated by Austin’s theses. With respect to gender theory as developed by Judith Butler, and to Erika Fischer-Lichte’s concept of the ‘transformative power of performance,’ it posits that both here and in the case of speech acts, the previous conceptual frame of performances or performing acts is crucial for the effectiveness of the respective acts. In particular with regard to theatrical performances, it holds that the aesthetic productivity of art performances does not primarily reside in their performative character as such, but rather in their potential to become (albeit in rare cases) the site of phenomena of emergence.
Ein Opfer für Ares
Authors: Gödde Susanne 
Published: February 2020

Abstract
This paper analyses the human sacrifice of Menoeceus in Euripides’ Phoenissae. In the third epeisodion, Teiresias draws on the history of Thebes and its royal family to justify the sacrifice and the choice of Menoeceus as its victim. But what are the ritual or cultural models outside the dramatic fiction that inform this sacrifice and made it under­standable for the contemporary ancient Athenian audience? To answer this question, I discuss possible similarities to pre-battle sacrifice, the pharmakos-ritual, and the mythical pattern of a hero who sacrifices himself for the community. The relation of this sacrifice to the foundation of Thebes, which itself plays a prominent role in the play’s choral odes, is then examined in a concluding section. Here, the crucial question is whether the sacrifice restates the act of foundation and its violence or instead negates and invalidates it.
Zur Poetik der Pflanzennamen in der Botanik: Carl von Linné
Authors: Kranz Isabel 
Published: February 2020

Abstract
The aim of the following paper is to highlight the poetics of plant names in non-literary texts, namely in the writings of Carl Linnaeus. The first part of the article presents an overview of research on the question of whether plant names have (semantic) meaning. It details the systematics of botanical and vernacular nomenclature and interrogates the relationship between plant names and proper names. The following two parts are devoted to the founder of modern botany, Carl Linnaeus, whose lasting importance lies in systematizing existing plant names as well as establishing a code of rules for future nomenclature. By analyzing a scene in which a plant is (re)named as well as some of the naming rules in his Philosophia botanica (1751), the paper shows that the Swedish nomenclator botanicus already took the poetic dimensions of plant names into account.
Morbidity, mortality and case fatality rate from chronic hepatitis B with and without a delta agent in Kyrgyzstan for the period 2010–2017
Authors: Nogoibaeva K. A. , Tobokalova S. T. , Kasymbekova K. T. , Umarova S. I. 
Published: March 2020

The purpose of the study is to research the morbidity, mortality and case fatality rate y of chronic viral hepatitis B without and with a delta agent from 2010–2017. in Kyrgyzstan.Materials and methods: analyzed state reporting forms No. 12 “Report on morbidity and preventive work (family medicine center, dispensary)” and “C51 — Distribution of deaths by sex, age groups and causes of death” from 2010–2017. Data processed by Microsoft Office Excel.Results: In the country from 2010–2017 3292 cases of chronic viral hepatitis B were detected, 1738 patients of them verified an independent course (СhHBV), and 1,554 patients combined with a delta agent (СhHDV), while the incidence did not have a statistically significant difference (3.80/0000, 95% CI 2.4–4.0 and 3.40/0000, 95% CI 2.2–3.4, СhHBV and СhHDV, respectively) were 20 times lower compared to the HBV Carrier (60 40/0000). There was no statistically significant difference between the cumulative morbidity, mortality, case fatality rate and the proportion of deaths in СhHBV and СhHDV. The death rate СhHBV increased by 4.7 times (0.090/0000 and 0.410/0000), case fatality rate — by 11.8 times (1355.00/0000 and 16025.60/0000) amid a decrease the incidence is 2.5 times (6.40/0000 and 2.50/0000) from 2014 to 2017, respectively. At СhHDV, the mortality rate was also increased by 4.7 times (0.030/0000 and 0.160/0000), case fatality rate — by 32.3 times (793.70/0000 and 25641.80/0000) against the background of a decrease in incidence by 6.9 times (4.40/0000 and 0.60/0000) from 2014 to 2017, respectively.Conclusion: In Kyrgyzstan from 2010–2017, relatively low detectability of chronic forms of HBV infection with and without delta agent was found, compared with the “HBV carrier”. There has been an increase in mortality and case fatality rate over the past 4 years, with a sharp rise in 2017 against the background of a downward trend in the incidence of СhHBV and СhHDV.
Efficiency and safety of opioid therapy of chronic pain syndrome in patients with cancer of the refractory iron: clinico-pathogenetic features
Authors: Bobrova O. P. , Schneider N. A. , Petrova M. M. , Dmitrenko D. V. , Zyryanov S. K. , Zobova S. N. 
Published: March 2020

Aim. To study the influence of clinical and pathogenetic factors in patients with pancreatic cancer on the efficacy and safety of analgesic therapy of chronic pain syndrome.Materials and methods. Clinical features of formation of chronic pain syndrome predetermining the efficacy and safety of analgesic therapy were studied in 82 patients with pancreatic cancer.Results. The efficacy and safety of opioids in the comparison groups of morphine sulfate, fentanyl TTC and oxycodone / naloxone in patients with pancreatic cancer was shown.