bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of cardiovascular imaging for myocardial injury in hospitalized COVID-19 patients
Authors: Cosyns Bernard , Lochy Stijn , Luchian Maria Luiza , Gimelli Alessia , Pontone Gianluca , Allard Sabine D , de Mey Johan , Rosseel Peter , Dweck Marc , Petersen Steffen E , Edvardsen Thor 
Published: April 2020

Abstract
Recent EACVI recommendations described the importance of limiting cardiovascular imaging during the COVID-19 pandemic in order to reduce virus transmission, protect healthcare professionals from contamination, and reduce consumption of personal protective equipment. However, an elevated troponin remains a frequent request for cardiac imaging in COVID-19 patients, partly because it signifies cardiac injury due to a variety of causes and partly because it is known to convey a worse prognosis. The present paper aims to provide guidance to clinicians regarding the appropriateness of cardiac imaging in the context of troponin elevation and myocardial injury, how best to decipher the mechanism of myocardial injury, and how to guide patient management.
Door-to-balloon time and mortality in patients with ST-elevation myocardial infarction undergoing primary angioplasty
Authors: Karkabi Basheer , Meir Gal , Zafrir Barak , Jaffe Ronen , Adawi Salim , Lavi Idit , Flugelman Moshe Y , Shiran Avinoam 
Published: April 2020

AbstractAimsThe evidence are not conclusive that a small incremental increase in door-to-balloon (D2B) time leads to a significant increase in death of ST-elevation myocardial infarction (STEMI) patients. In a previous study, we described a quality improvement intervention that reduced D2B time in 333 patients with STEMI. The aim of the current study was to compare mortality rates of the patients, before and after the intervention.Methods and resultsWe examined the survival of 133 consecutive patients with STEMI treated prior to an intervention to decrease D2B time and 200 treated after the intervention. The mortality rate was the same before and after the quality intervention. The median D2B time for the entire cohort was 55 min. The number of patients with D2B time &gt;55 min prior to the intervention was 82/133 (61%) and after the intervention 74/200 (37%) P &lt; 0.00001. Thirty-day mortality among the patients with D2B time ≤55 min was 5/178 (2.8%) and among those with D2B time &gt;55 min was 15/155 (9.7%), P &lt; 0.008. The hazard ratio for 30-day mortality when the D2B time was &gt;55 min was 3.7 (1.3–10.4).ConclusionMortality and non-fatal complications did not differ significantly between STEMI patients before and after a quality improvement intervention. However, the number of patients treated within 55 min from arrival was significantly higher after the intervention; and coronary intervention within this time was associated with a lower death rate.
COMPUTATIONAL EXPLORATION OF GERONTOLOGY-RELATED TOPICS SHARED ON SOCIAL MEDIA PLATFORM TWITTER
Authors: Cornet V , Hong M 
Published: April 2020

Abstract
Twitter, a popular Internet social media platform, has become a significant medium for sharing information and ideas about various topics, including aging and older adults. While studies have been conducted to examine stigma or perception about specific diseases such as Alzheimer’s disease and seizure on Twitter, there has been little effort to identify general themes of Twitter posts related to aging and older adults. This exploratory study attempts to answer this need by conducting a topic analysis of posts shared on Twitter posts about aging and older adults in English. We collected 328,568 English posts from Twitter posted between 07/01/18 and 07/31/18 using 19 English keywords referring to older adults. We analyzed this whole dataset as well as a subset of posts explicitly including aging-related hashtags, such as #olderadults. We used data mining methods (including Latent Dirichlet Allocation) in computing environment MATLAB to discover topics emerging from these two sets. Among posts with explicit aging-related hashtags, the most recurrent topics were family (relation with children and grandchildren, commemoration), community (resources, looking after older adults), health (disease-specific, public health, home care, formal and informal caregivers), politics and policies (insurance/pension, new laws), and news involving older adults (e.g., crimes on/by older adults). The analysis of the larger dataset additionally uncovered posts promoting pornography featuring older females and posts sharing general Internet content featuring older adults (e.g., YouTube videos). We also share the methodological challenges we encountered and practical recommendations for gerontological researchers interested in using social media data to inform new research.
Seismoelectric monitoring of aquifers using local seismicity—a feasibility study
Authors: Dzieran L , Thorwart M , Rabbel W 
Published: April 2020

SUMMARYSeismoelectric (SE) signals, accompanying seismic wave fields radiated from earthquakes, can be observed on records of magnetotelluric stations. Assuming that these SE signals are generated by electrokinetic coupling we investigate whether they can be used as a ‘pore-space monitoring’-tool. Regarding future field experiments we analyse synthetic SE waveforms calculated for a fully saturated base model consisting of five layers overlying a half-space, resembling the conditions of the Armutlu Peninsula (Turkey). This example site stands for a location with near-surface thermal aquifers exposed to tectonic stress and significant microseismicity. As expected, coseismic SE waves arrive simultaneously with the seismic onsets whereas interface response (IRs) SE waves arrive (shortly) before the generating seismic onsets. Therein, so-called evanescent IRs show a similar moveout as seismic phases and so-called radiation IRs travel with zero slowness. We found that the influence of IRs on the overall SE signal can be identified by envelope analysis of SE time series and by seismoelectric spectral ratios (SESRs) in the frequency domain. For a sensitivity analysis we added an extra layer to the base model with differing porosity, porefluid salinity and permeability values. At near-epicentral distances both trace-envelopes and SESRs are sensitive to the porosity and porefluid salinity changes in the simulated near-surface aquifer. The SESRs’ and SE envelopes’ amplitudes vary in the order of up to some 10 per cent in response to porosity and salinity increases of factor 2 and 100, respectively. In contrast, a decrease of the permeability value by the factor 100 leads to an SESR amplitude variation of less than 1–10 per cent. In the Armutlu model the largest relative changes of SE signals occur near the epicentre where the ratio between coseismic and IR amplitudes is close to 1. For 1–6 km deep source depth the SE detection swell at the earth surface is in the order of magnitude 2–3, depending on the ambient electromagnetic noise and hypocentral distance. This estimate assumes that SE signals are recorded with standard magnetotelluric stations. It can improve if array methods are applied.
A combined NMR, MD and DFT conformational analysis of 9-O-acetyl sialic acid-containing GM3 ganglioside glycan and its 9-N-acetyl mimic
Authors: Li Wanqing , Battistel Marcos D , Reeves Hannah , Oh Lisa , Yu Hai , Chen Xi , Wang Lee-Ping , Freedberg Darón I 
Published: April 2020

Abstract
O-Acetylation of carbohydrates such as sialic acids is common in nature, but its role is not clearly understood due to the lability of O-acetyl groups. We demonstrated previously that 9-acetamido-9-deoxy-N-acetylneuraminic acid (Neu5Ac9NAc) is a chemically and biologically stable mimic of the 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2) of the corresponding sialoglycans. Here, a systematic nuclear magnetic resonance (NMR) spectroscopic and molecular dynamics (MD) simulation study was undertaken for Neu5,9Ac2-containing GM3 ganglioside glycan (GM3-glycan) and its Neu5Ac9NAc analog. GM3-glycan with Neu5Ac as the non-O-acetyl form of Neu5,9Ac2 was used as a control. Complete 1H and 13C NMR chemical shift assignments, three-bond 1H-13C trans-glycosidic coupling constants (3JCH), accurate 1H-1H coupling constants (3JHH), nuclear Overhauser effects and hydrogen bonding detection were carried out. Results show that structural modification (O- or N-acetylation) on the C-9 of Neu5Ac in GM3 glycan does not cause significant conformational changes on either its glycosidic dihedral angles or its secondary structure. All structural differences are confined to the Neu5Ac glycerol chain, and minor temperature-dependent changes are seen in the aglycone portion. We also used Density Functional Theory (DFT) quantum mechanical calculations to improve currently used 3JHH Karplus relations. Furthermore, OH chemical shifts were assigned at −10°C and no evidence of an intramolecular hydrogen bond was observed. The results provide additional evidence regarding structural similarities between sialosides containing 9-N-acetylated and 9-O-acetylated Neu5Ac and support the opportunity of using 9-N-acetylated Neu5Ac as a stable mimic to study the biochemical role of 9-O-acetylated Neu5Ac.
GnRH agonist and hCG (dual trigger) versus hCG trigger for final follicular maturation: a double-blinded, randomized controlled study
Authors: Haas J , Bassil R , Samara N , Zilberberg E , Mehta C , Orvieto R , Casper R F 
Published: April 2020

Abstract

STUDY QUESTION
Does co-administration of GnRH agonist and Human chorionic gonadotropin (hCG; dual trigger) in IVF cycles improve the number of mature oocytes and pregnancy outcome compared to hCG alone?

SUMMARY ANSWER
Using the dual trigger for final follicular maturation increases the number of oocytes, mature oocytes and number of blastocysts (total and top-quality) compared to triggering with hCG alone.

WHAT IS KNOWN ALREADY
hCG is used at the end of controlled ovarian hyperstimulation as a surrogate LH surge to induce final oocyte maturation. Recently, based on retrospective studies, the co-administration of GnRH agonist and hCG for final oocyte maturation (dual trigger) has been suggested to improve IVF outcome and pregnancy rates

STUDY DESIGN, SIZE, DURATION
A single center, randomized controlled, double-blinded clinical trial between May 2016 and June 2018 analyzed by intention to treat (ITT).

PARTICIPANTS/MATERIALS, SETTINGS, METHODS
One hundred and fifty-five normal responder patients were randomized either to receive hCG or dual trigger for final oocyte maturation. Data on patients age, BMI, AMH, number of oocytes retrieved, number of metaphase 2 (MII) oocytes, zygotes and blastocysts, clinical pregnancy rate and live birth rate were assessed and compared between the dual trigger group and the hCG group. We performed a planned interim analysis after the recruitment of 50% of the patients. Based on the totality of outcomes at the interim analysis we decided to discontinue further recruitment.

MAIN RESULTS AND THE ROLE OF CHANCE
One hundred and fifty-five patients were included in the study. The age (36 years versus 35.3 years P = NS), BMI (24 kg/m2 versus 23.7 kg/m2) and the AMH (20.1 pmol/l versus 22.4 pmol/l) were comparable between the two groups. Based on ITT analysis, the number of eggs retrieved (11.1 versus 13.4, P = 0.002), the MII oocytes (8.6 versus 10.3, P = 0.009), total number of blastocysts (2.9 versus 3.9, P = 0.01) and top-quality blastocysts transferred (44.7% versus 64.9%; P = 0.003) were significantly higher in the dual trigger group compared to the hCG group. The clinical pregnancy rate (24.3% versus 46.1%, OR 2.65 (1.43–1.93), P = 0.009) and the live birth rate per transfer (22% versus 36.2%, OR= 1.98 (1.05–3.75), P = 0.03) were significantly higher in the dual trigger group compared to the hCG group.

LIMITATIONS, REASONS FOR CAUTION
None.

WIDER IMPLICATIONS OF THE FINDINGS
The enhanced response observed with the dual trigger might lead to better IVF outcomes were it used more widely.

STUDY FUNDING/COMPETING INTEREST(S)
The study was funded by TRIO Fertility. There are no conflicts of interest to declare.

TRIAL REGISTRATION NUMBER
ClinicalTrials.gov identifier: NCT02703584

DATE OF TRIAL REGISTRATION
March 2016

DATE OF FIRST PATIENT'S ENROLLMENT
May 2016
Bumblebees Use Sequential Scanning of Countable Items in Visual Patterns to Solve Numerosity Tasks
Authors: MaBouDi HaDi , Galpayage Dona H Samadi , Gatto Elia , Loukola Olli J , Buckley Emma , Onoufriou Panayiotis D , Skorupski Peter , Chittka Lars 
Published: April 2020

Abstract
Most research in comparative cognition focuses on measuring if animals manage certain tasks; fewer studies explore how animals might solve them. We investigated bumblebees’ scanning strategies in a numerosity task, distinguishing patterns with two items from four and one from three, and subsequently transferring numerical information to novel numbers, shapes, and colors. Video analyses of flight paths indicate that bees do not determine the number of items by using a rapid assessment of number (as mammals do in “subitizing”); instead, they rely on sequential enumeration even when items are presented simultaneously and in small quantities. This process, equivalent to the motor tagging (“pointing”) found for large number tasks in some primates, results in longer scanning times for patterns containing larger numbers of items. Bees used a highly accurate working memory, remembering which items have already been scanned, resulting in fewer than 1% of re-inspections of items before making a decision. Our results indicate that the small brain of bees, with less parallel processing capacity than mammals, might constrain them to use sequential pattern evaluation even for low quantities.
Division by 1–ζ on Superelliptic Curves and Jacobians
Authors: Arul Vishal 
Published: April 2020

Abstract
Yuri Zarhin gave formulas for “dividing a point on a hyperelliptic curve by 2”. Given a point $P$ on a hyperelliptic curve $\mathcal{C}$ of genus $g$, Zarhin gives the Mumford representation of an effective degree $g$ divisor $D$ satisfying $2(D - g \infty ) \sim P - \infty $. The aim of this paper is to generalize Zarhin’s result to superelliptic curves; instead of dividing by 2, we divide by $1 - \zeta $. There is no Mumford representation for divisors on superelliptic curves, so instead we give formulas for functions that cut out a divisor $D$ satisfying $(1 - \zeta ) D \sim P - \infty $. Additionally, we study the intersection of $(1 - \zeta )^{-1} \mathcal{C}$ and the theta divisor $\Theta $ inside the Jacobian $\mathcal{J}$. We show that the intersection is contained in $\mathcal{J}[1 - \zeta ]$ and compute the intersection multiplicities.
Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019
Authors: Zhang Yonghong , Qin Ling , Zhao Yan , Zhang Ping , Xu Bin , Li Kang , Liang Lianchun , Zhang Chi , Dai Yanchao , Feng Yingmei , Sun Jianping , Hu Zhongjie , Xiang Haiping , Knight Julian C , Dong Tao , Jin Ronghua 
Published: April 2020

AbstractA major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.
Stability of Cocaine Compounds in Biological Fluids During Post-Analytical Sample Storage
Authors: Huertas Teresa , Jurado Carmen , Salguero Manuel , Soriano Teresa , Gamero Joaquin 
Published: April 2020

AbstractThe objective of this study is to evaluate in vitro stability of cocaine compounds, cocaine (COC), benzoylecgonine (BE), ecgonine methyl ester (EME) and benzoylecgonine ethyl ester (EBE), in blood and urine, during post-analysis custody. Stability was evaluated by measuring percent recovery. Parameters evaluated were time of custody (1 year), storage temperature (−20°C and 4°C), influence of preservative (only for blood samples) and pH (only for urine samples). The impact of the temperature is very important in blood samples. At −20°C all compounds demonstrated to be stable, with recoveries higher than 80% after 1 year. In contrast, degradation was observed in the concentration for all four compounds when the samples were maintained at 4°C. In these same conditions, the influence of the preservative was also noticeable and a higher stability was found in samples preserved with NaF. COC and EBE had similar profiles, and both compounds disappeared after 30 days in samples without NaF and after 150 days in samples with NaF added. EME disappeared after 185 days and after 215 days in samples without and with preservative, respectively. BE recoveries, after 365 days of storage, were 68.5% (in samples with NaF) and 3.7% (in samples without NaF). In urine samples, the four compounds were stable in all the studied conditions except when samples were at pH 8 and stored at 4°C where the compounds disappeared (COC and EBE after 75 days of storage and EME after 15 days). The exception was BE, with a recovery of 23% after 1 year of storage. Of the temperatures evaluated, −20°C seems to be optimal for storage to maintain the stability of cocaine and metabolites in biological samples. This can be further enhanced by maintaining a pH of 4 in urine samples and adding a NaF preservative to blood.
General Considerations for On-Animal Ectoparasiticidal Product Evaluations
Authors: Smythe Brandon G , Sanchez-Sandoval Ulises A 
Published: April 2020

Abstract
Successfully preparing for and conducting on-animal ectoparasiticidal evaluations is key in providing accurate results and inferences on product performance. However, the procedures associated with designing sound-reliable research projects while using animal test subjects can become complex. The current manuscript offers insights towards the characterization of different evaluation types highlighting key considerations and potential problematic barriers that may otherwise be overlooked by researchers new to the area of on-animal product evaluation. Furthermore, recommendations on reporting inferences from findings based on various study designs are discussed. The authors of the current manuscript offer these considerations in the hopes of maintaining harmony in future reports used to develop and evaluate on-animal ectoparsiticidal products in the field of veterinary entomology.
Large extended abdominoplasty—dispelling the myths of prohibitively high BMI’s: a case report
Authors: Zhitny Vladislav Pavlovich , Iftekhar Noama , Zide Barry , Stile Frank 
Published: April 2020

ABSTRACT
Abdominoplasty is one of the most highly requested cosmetic procedures in the USA. Although it is famed for its cosmetic value, there are few reports that discuss its therapeutic potential. Furthermore, few abdominoplasties are completed in patients over the body mass index (BMI) of 30 due to fears of increased complications.
A 63-year-old male presented due to development of a large pannus following weight loss postgastric bypass. Unfortunately, because of this pannus, the patient began experiencing significant physical and emotional distress. The patient had difficult urinating, ambulating and could no longer engage in sexual activity. The patient underwent abdominoplasty for removal of the pannus. At the 5-month follow-up, patient exhibited resolution of his symptoms.
Abdominoplasty should not be limited to cosmetic procedures. It holds therapeutic value, and the BMI should not be listed as a firm contraindication to the procedure.
Conservation of centromeric histone 3 interaction partners in plants
Authors: Keçeli Burcu Nur , Jin Chunlian , Van Damme Daniel , Geelen Danny 
Published: April 2020

Abstract
The loading and maintenance of centromeric histone 3 (CENH3) at the centromere are critical processes ensuring appropriate kinetochore establishment and equivalent segregation of the homologous chromosomes during cell division. CENH3 loss of function is lethal, whereas mutations in the histone fold domain are tolerated and lead to chromosome instability and chromosome elimination in embryos derived from crosses with wild-type pollen. A wide range of proteins in yeast and animals have been reported to interact with CENH3. The histone fold domain-interacting proteins are potentially alternative targets for the engineering of haploid inducer lines, which may be important when CENH3 mutations are not well supported by a given crop. Here, we provide an overview of the corresponding plant orthologs or functional homologs of CENH3-interacting proteins. We also list putative CENH3 post-translational modifications that are also candidate targets for modulating chromosome stability and inheritance.
Molybdenum induces alterations in the glycerolipidome that confer drought tolerance in wheat
Authors: Wu Songwei , Hu Chengxiao , Yang Xiaozhen , Tan Qiling , Yao Shuaibing , Zhou Yuan , Wang Xuemin , Sun Xuecheng 
Published: April 2020

Abstract
Molybdenum (Mo), which is an essential microelement for plant growth, plays important roles in multiple metabolic and physiological processes, including responses to drought and cold stress in wheat. Lipids also have crucial roles in plant adaptions to abiotic stresses. The aim of this study was to use glycerolipidomic and transcriptomic analyses to determine the changes in lipids induced by Mo that are associated with Mo-enhanced drought tolerance in wheat. Mo treatments increased the transcript levels of genes involved in fatty acid and glycerolipid biosynthesis and desaturation, but suppressed the expression of genes involved in oxylipin production. Wheat plants supplemented with Mo displayed higher contents of monogalactosyldiacyglycerol (MGDG), digalactosyldoacylglycerol (DGDG), phosphatidylglycerol (PG), phosphatidylethanolamine (PE), and phosphatidylcholine (PC) with increased levels of unsaturation. The levels of MGDG, DGDG, PG, and PC increased under PEG-simulated drought (PSD), and the magnitude of the responses varied in the presence and absence of Mo. Mo increased the accumulation of the most abundant glycerolipid species of C36:6, C34:4, and C34:3 by increasing the expression of genes related to desaturation under PSD, and this contributed to maintaining the fluidity of membranes. In addition, Mo attenuated the decreases in the ratios of DGDG/MGDG and PC/PE that were observed under PSD. These changes in lipids in Mo-treated wheat would contribute to maintaining the integrity of membranes and to protecting the photosynthetic apparatus, thus acting together to enhance drought tolerance.