bluuebunny/crossref_metadata_2025_split huggingface dataset:
TNFα priming through its interaction with TNFR2 enhances Endothelial Progenitor Cell immunosuppressive effect: a new hope for their widespread clinical application
Authors: BARKESTANI Mahsa NOURI , SHAMDANI Sara , BAKSHLOO Mazdak AFSHAR , AROUCHE Nassim , BAMBAI Bijan , UZAN Georges , NASERIAN Sina 
Published: September 2020

Abstract
Background
Bone marrow derived endothelial progenitor cells (EPCs) are immature endothelial cells (ECs) involved in neo-angiogenesis and endothelial homeostasis and are considered as a circulating reservoir for endothelial repair. Many studies showed that EPCs from patients with hematological and cardiovascular pathologies are impaired and insufficient; hence, allogenic sources from adult or cord blood are considered as good options for cell therapy applications. However, allogenic condition increases the chance of immune rejection, especially by T cells, before exerting the desired regenerative functions. TNFα is one of the main mediators of EPC activation that recognizes two distinct receptors. TNFR1 has ubiquitous expression and its interaction with TNFα leads to deleterious effects and apoptosis, whereas, TNFR2 is expressed on few cell types and is involved in protective and survival mechanisms. We have recently reported that human EPCs are immunosuppressive and this effect was TNFα-TNFR2 dependent. Here, we aimed to investigate if an adequate TNFα pre-conditioning could increase TNFR2 expression and prime EPCs towards more immunoregulatroy functions.
Methods
EPCs were pre-treated with several doses of TNFα to find the proper dose to up-regulate TNFR2 while keeping TNFR1 stable. Then, co-cultures of human EPCs and T cells were performed to assess if EPC immunoregulatory effect is increased.
Results
Treating EPCs with 1 ng/ml TNFα significantly up-regulated TNFR2 expression without unrestrained increase of TNFR1 and other endothelial injury markers. Moreover, TNFα priming through its interaction with TNFR2 remarkably enhanced EPC immunosuppressive and anti-inflammatory effects. Conversely, TNFα-TNFR1 interaction polarized EPCs towards pro-inflammatory and immunogenic functions.
Conclusions
We report for the first time the crucial role of inflammation, notably, the implication of TNFα-TNFR2 axis to boost EPC immunoregulatory functions. Priming EPCs with proper dose of TNFα prior to administration could provide a more protective immunosuppressive microenvironment and longer lasting cells which eventually lead to their better contribution to hematopoietic and vascular regeneration.
Determinants of low breastfeeding self-efficacy amongst mothers of children aged less than six months old: Results from the BADUTA Study in East Java, Indonesia
Authors: Titaley Christiana R , Dibley Michael , Ariawan Iwan , Mu'asyaroh Anifatun , Alam Ashraful , Damayanti Rita , Tran Do Thanh , Ferguson Elaine , Kyaw Htet , Li Mu , Sutrisna Aang , Fahmida Umi 
Published: September 2020

Abstract
Background Despite the increasing rate of exclusive breastfeeding practice in Indonesia, supportive interventions are still required. Breastfeeding self-efficacy of mothers is a key factor positively associated with optimum breastfeeding practices. Our analysis aims to assess the determinants of low breastfeeding self-efficacy amongst a sample of women with children aged under six months in Malang and Sidoarjo Districts, East Java, Indonesia. Methods We used information from 1210 mothers of children aged <6 months recruited in the BADUTA study conducted in 2015-2016 in Malang and Sidoarjo Districts. The outcome variable in this analysis was mothers' self-efficacy for breastfeeding using the 14 statements in the Breastfeeding Self Efficacy-Short Form. In total, 17 potential predictors of breastfeeding self-efficacy were evaluated, categorised into six sub-groups: (1) context/demographic variables; (2) household characteristics; (3) maternal characteristics; (4) child characteristics; (5) breastfeeding characteristics; and (6) antenatal and delivery care characteristics. Logistic regression analyses were employed to examine factors associated with mothers' self-efficacy with breastfeeding. Results More than half of the women had a low level of self-efficacy. Factors associated with low breastfeeding self-efficacy were low levels of education, i.e. completed primary school or lower (aOR=1.95, 95%CI: 1.20-3.15), completed junior high school aOR=2.30; 95%CI: 1.44-3.69), and completed senior high school (aOR=2.01, 95%CI: 1.34-3.00); working outside the house (aOR=1.72, 95% CI: 1.26-2.35); never received any advice on breastfeeding (aOR=1.37, 95%CI: 1.04-1.81) and low knowledge of breastfeeding (aOR=1.38, 95%CI: 1.04-1.85). Problems encountered with breastfeeding was also emerged as a significant predictor for low breastfeeding self-efficacy, either for mothers receiving solutions (aOR=2.16, 95%CI: 1.58-2.95) or those not receiving any solutions (aOR=2.65, 95% CI: 1.91-3.67). Furthermore, mothers who had cesarean section deliveries were more likely to have low breastfeeding self-efficacy (aOR=1.33, 95%CI: 1.06-1.68); while mothers exposed to three or more breastfeeding interventions were more likely to have a high level of breastfeeding self-efficacy (aOR=1.84, 95%CI: 1.03-3.27). Conclusions Multipronged breastfeeding education programs and support are required to improve women's self-efficacy with breastfeeding. Improved access to breastfeeding counsellors, active support for mothers following cesarean delivery, and increased supporting facilities at workplaces are essential to improve self-efficacy with breastfeeding.
Assessing vulnerability and adopting alternative climate resilient strategies for livelihood security and sustainable management of aquatic biodiversity of Vembanad lake in India
Authors: Paul Thankam Theresa , Panikker Preetha , Sarkar U. K. , Manoharan S. , Kuberan G. , Sreenath K. R. , Zachariah P. U. , Das B. K. 
Published: September 2020

Abstract
The present study was carried out at the Thycattussery area in Vembanad lake and assessed the ichthyo-diversity, variability in climatic variables, the exploited status of predominant small-scale sector fisheries (SSFs) and impact of climatic variables upon an existing SSF. Fish, as well as clam specimens collected from the study area, were identified. Diversity indices and dominance curves helped to identify monsoon (June–September) as the diverse season in the wetland. SIMPER (similarity percentage) analysis indicated that Villorita cyprinoides (clam) was the predominant species in the wetland with a mean relative abundance of 16.1%. Canonical correspondence analysis (CCA) of variables with clam production identified calcium hardness and rainfall with axis loadings of –0.56 and 0.50 respectively as the variables predominantly contributing to clam production. Stepwise regression indicated that temperature and rainfall were the determinants of clam production. A decrease in rainfall and an increase in temperature at an annual rate of 0.02 and 0.8%, respectively, decreased the clam production by 5.37%/year in the study area. Further, the generalized linear model (GLM) indicated stagnancy in clam production until 2035 below 400,000 kg per year. The study introduced diversification of livelihood systems using clam culture in climate resilient pen structures (CRPS) as an adaptation strategy.
Spatiotemporal variation of actual evapotranspiration and its response to changes of major meteorological factors over China using multi-source data
Authors: Yang Jiahui , Wang Wen , Hua Tiantian , Peng Min 
Published: September 2020

Abstract
Evapotranspiration (ET) is an important component of the water and energy cycle. To obtain more accurate actual ET estimation, three commonly used actual ET products (i.e., GLEAM, GLDAS, and SSEBop) are merged by the simple Taylor skill score fusion method. Validation results show that the merged actual ET data exhibits better correlation with eddy-covariance ET observation than single-source ET data. Based on the merged ET, the spatiotemporal variations of ET over China and their links to changes of three meteorological factors, i.e., precipitation, air temperature (Ta), and shortwave radiation (Rs), are analyzed. During 2003–2016, there is a general upward trend in ET with an increase rate of 1.6 mm/year over China. ET increases very significantly in northeastern China, the southern coastal region, and the northwestern corner of China, whereas it decreases significantly in Huang-Huai-Hai Plain. There is a clear spatial pattern of the relationship between ET and its driving factors, i.e., the variation of ET in the humid southeast is dominated by Ta and Rs; in the semi-humid and semi-arid zone, the variation of ET is controlled mainly by precipitation, followed by Ta; and in arid northwestern China, the variation of ET is controlled mainly by precipitation.
Venoms and Poisonings during the Centuries: A Narrative Review
Authors: Charitos Ioannis Alexandros , Gagliano-Candela Roberto , Santacroce Luigi , Bottalico Lucrezia 
Published: September 2020

:
The first traces of man’s of poison use date back to ten thousand years ago since the last period of the Paleolithic era. Man used poison for hunting and defense. Indeed, in the second half of the 19th century, arrows made from the bones of animals characterized by particular grooves were found in some caves. In ancient Greece, the term pharmakon (φάρμακον) had a double meaning: remedy for therapy and venom. This is the period in which humans became aware of the fact that poison cannot be defined simply as a substance capable of changing the properties of things. Poison is very frequently mentioned in the history of the Roman Empire, and its use continued through the Renaissance and even during the modern era. Poison was the protagonist in multiple political in-trigues of power and is one of the most used lethal weapons over the years. Thought of as the opti-mal solution for a perfect murder, the poison has a long history. Its success is due to the invisible, untraceable, and often unpunished death it causes.
Danos colaterais: a Organização Mundial do Comércio e a «guerra comercial» EUA-China
Authors: Fernandes José Pedro Teixeira 
Published: September 2020

Resumo
Uma ‘guerra comercial’ entre as duas maiores potencias comerciais estaduais (os EUA e a China) eclodiu nos últimos anos, provocando efeitos negativos no comércio internacional. Face a este contexto, o principal objectivo deste artigo é procurar compreender a forma como o conflito comercial EUA-China se projecta nesta. Para responder a este objectivo foi usada uma metodologia de tipo qualitativo assente numa pesquisa documental e complementarmente num recurso à literatura científica relevante para esta temática. Foram ainda usados estudos empíricos para obtenção de dados quantitativos sobre litígios comerciais internacionais. Quanto à análise, foi estruturada da seguinte forma. Um primeiro ponto aborda a formação do sistema comercial global contemporâneo. Em seguida é analisada a transformação do optimismo inicial sobre a OMC num crescente cepticismo. É ainda discutido o impacto que a adesão da China à OMC teve na perda de atracção euro-americanapela organização. Nos pontos subsequentes são analisadas as repercussões da «guerra comercial» EUA-China no Órgão de Resolução de Litígios e o uso da excepção de segurança. A análise termina com uma breve reflexão sobre a forma como os problemas e as tendências identificados se projectam no futuro da OMC e do comércio global.
PENGARUH MOTIVASI BELAJAR EKONOMI DAN LINGKUNGAN TEMAN SEBAYA TERHADAP HASIL BELAJAR MATA PELAJARAN EKONOMI SISWA KELAS X
Authors: Karimah Neni Afriul , Sunanik Sunanik 
Published: September 2020

Abstrak: Tujuan dari penelitian ini adalah : (1) mengetahui pengaruh motivasi belajar ekonomi terhadap hasil belajar mata pelajaran ekonomi siswa kelas X SMAN 1 Kampak tahun pelajaran 2017/2018, (2) mengetahui pengaruh lingkungan teman sebaya terhadap hasil belajar mata pelajaran ekonomi siswa kelas X SMAN 1 Kampak tahun pelajaran 2017/2018, (3) mengetahui pengaruh motivasi belajar ekonomi dan lingkungan teman sebaya terhadap hasil belajar mata pelajaran ekonomi siswa kelas X SMAN 1 Kampak tahun ajaran 2017/2018. Populasi penelitian ini adalah siswa kelas X SMA Negeri 1 Kampak yang berjumlah 185 siswa. Sampel diambil 40% dari populasi yaitu sebanyak 74 siswa. Teknik pengambilan sampling dilakukan dengan Proporsional random sampling. Dengan demikian penelitian ini disimpulkan “ada pengaruh signifikan antara motivasi belajar ekonomi dan lingkungan teman sebaya terhadap hasil belajar mata pelajaran ekonomi”. Hasil penelitian ini dapat digunakan untuk masukan dalam meningkatkan hasil belajar mata pelajaran ekonomi.Abstract: This research aims to (1) identify whether or not the influence of Economic learning motivation toward learning results in Economic subject in grade X students in SMAN 1 Kampak 2017/2018 exists, (2) identify whether or not the influence of peer environment toward learning results in Economic subject in grade X students in SMAN 1 Kampak 2017/2018 exists, (3) identify whether or not Economic learning motivation and peer environment toward learning results in Economic subject in grade X students in SMAN 1 Kampak 2017/2018 exist. The population of this research is all grade X students in SMAN 1 Kampak. 185 students become the population of this research. The sample of this research is 40% of the population. 74 students become the sample of this research. Proportional random sampling is used as a sampling technique for this research. Therefore, it can be concluded that there is a significant influence between Economic learning motivation and peer environment toward students’ learning results. The results of this research can then be used as a consideration to advance the students’ learning results in Economic subject.
PENERAPAN MODEL PEMBELAJARAN EXAMPLES NON EXAMPLES PADA MATERI KELOMPOK SOSIAL DALAM UPAYA PENINGKATAN PARTISIPASI DAN HASIL BELAJAR PESERTA DIDIK DI SMAN 2 BANJAR
Authors: Hadi Saeful 
Published: September 2020

Abstrak: Penelitian ini bertujuan untuk mengetahui penerapan model pembelajaran Examples Non Examples ditinjau dari partisipasi dan hasil belajar peserta didik di SMAN 2 Banjar. Penelitian ini merupakan penelitian tindakan kelas dengan menggunakan 2 siklus. Pada setiap siklus terdiri dari perencanaan, pelaksanaan, observasi dan refleksi. Subjek pada penelitian ini adalah peserta didik kelas XI. IPS4 SMA Negeri 2 Banjar pada materi Kelompok Sosial pada mata pelajaran Sosiologi. Berdasarkan hasil penelitian menunjukkan peningkatan hasil yang dicapai peserta didik dalam menguasai materi kelompok sosial. Peningkatan partisipasi belajar hasil pengamatan dari pengamatan awal sampai siklus 2 mengalami peningkatan yaitu 57,69% (siklus 1) menjadi 81,73% (siklus 2), nilai rerata tes ada peningkatan dari siklus 1 yaitu dengan rata-rata nilai 70,45 ke siklus 2 yaitu dengan rerata nilai 78,29 serta jumlah peserta didik yang tuntas dan persentase ketuntasan belajar pun meningkat dari 17 orang atau 54,84 % menjadi 24 orang atau 77,42% pada siklus 2.Abstract: This study aims to determine the application of learning models Examples Non Examples in terms of participation and learning outcomes of students at SMAN 2 Banjar. This research is a classroom action research using two cycles. In each cycle consists of planning, implementation, observation and reflection. The subjects in this study were students of class XI. IPS4 SMA 2 Banjar on Social Group material on Sociology subjects. Based on the results of the study showed an increase in the results achieved by students in mastering social group material. Increased learning participation observations from the initial observation until the second cycle experienced an increase of 57.69% (cycle 1) to 81.73% (cycle 2), the average score of the test was an increase from cycle one which is an average of 70.45 to cycle 2 is the average value of 78.29 and the number of students who complete and the percentage of mastery learning increases from 17 people or 54.84% to 24 people or 77.42% in cycle 2.
Classification of Depression Through Resting-State Electroencephalogram as a Novel Practice in Psychiatry: Review
Authors: Čukić Milena , López Victoria , Pavón Juan 
Published: September 2020

Background
Machine learning applications in health care have increased considerably in the recent past, and this review focuses on an important application in psychiatry related to the detection of depression. Since the advent of computational psychiatry, research based on functional magnetic resonance imaging has yielded remarkable results, but these tools tend to be too expensive for everyday clinical use.

Objective
This review focuses on an affordable data-driven approach based on electroencephalographic recordings. Web-based applications via public or private cloud-based platforms would be a logical next step. We aim to compare several different approaches to the detection of depression from electroencephalographic recordings using various features and machine learning models.

Methods
To detect depression, we reviewed published detection studies based on resting-state electroencephalogram with final machine learning, and to predict therapy outcomes, we reviewed a set of interventional studies using some form of stimulation in their methodology.

Results
We reviewed 14 detection studies and 12 interventional studies published between 2008 and 2019. As direct comparison was not possible due to the large diversity of theoretical approaches and methods used, we compared them based on the steps in analysis and accuracies yielded. In addition, we compared possible drawbacks in terms of sample size, feature extraction, feature selection, classification, internal and external validation, and possible unwarranted optimism and reproducibility. In addition, we suggested desirable practices to avoid misinterpretation of results and optimism.

Conclusions
This review shows the need for larger data sets and more systematic procedures to improve the use of the solution for clinical diagnostics. Therefore, regulation of the pipeline and standard requirements for methodology used should become mandatory to increase the reliability and accuracy of the complete methodology for it to be translated to modern psychiatry.
Using the primary site as a prognostic tool for nodal mantle cell lymphoma: a SEER-based study
Authors: Kamel Mohamed Gomaa , El-Qushayri Amr Ehab , Sayed Ahmed Kamal , Huy Nguyen Tien 
Published: September 2020

Background:Nodal mantle cell lymphoma (NMCL) has a worse survival than extra-nodal mantle cell lymphoma.Materials & methods:A cohort study was conducted to evaluate the primary site role as a mortality predictor using data from 1983 to 2011 from the Surveillance, Epidemiology, and End Results (SEER) database.Results:Most patients had NMCL in multiple regions (71.9%). There was a significantly increased incidence of NMCL cases over years with 83.2% of them occurred between 1998 and 2011. The mean survival was 52.9 months with overall survival/cancer-specific survival rate of 29.2/42.9%, respectively. Lymph nodes of intrathoracic and multiple regions had a worse overall survival while the head, face and neck, intra-abdominal, pelvic, inguinal region and leg as well as multiple regions had worse cancer-specific survival.Conclusion:NMCL primary site can serve as a prognostic factor. We encourage adding it to MCL International Prognostic Index.
Pendampingan Teknik Penambahan Suplemen Pada Ransum Indukan Ayam Bukan Ras Di Wilayah Plantungan Kabupaten Kendal
Authors: Krismiyanto Lilik , Mulyono Mulyono , Suthama Nyoman 
Published: September 2020

Peningkatan produksi ayam bukan ras dapat dilakukan dengan perbaikan ransum yang selama ini masih diberikan pakan apa adanya. Penyediaan bahan pakan sesuai dengan kebutuhan nutrien dapat meningkatkan produktivitas. Selain itu juga harus didukung dengan manajemen pakan, pemeliharaan, dan kesehatan. Pembinaan terhadap peternak perlu didampingi terus, terutama pada majanemen pakan. Ransum indukan ayam bukan ras biasanya menggunakan bahan pakan apa adanya, sehingga perlu adanya penambahan suplemen untuk meningkatkan produksi telur. Tujuan dalam pendampingan peternak adalah untuk memberikan informasi penambahan suplemen dalam ransum indukan ayam bukan ras. Manfaatnya adalah peternak mengetahui pentingnya suplemen dan mempraktekan cara formulasi ransum dengan penambahan suplemen. Pendampingan peternak indukan ayam bukan ras dilaksanakan di Kelompok Tani Ternak Kembangwono, Desa Plantungan, Kecamatan Sukorejo, Kabupaten Kendal, Jawa Tengah. Para peternak dibekali infomasi mengenai cara formulasi ransum, memilih bahan pakan yang murah dan tidak mengandung toksik, penambahan suplemen seperti premix, mineral mix, probiotik dan prebiotik. Pendampingan secara berkelanjutan dapat meningkatkan pengetahuan dan kemampuan peternak, sehingga output yang dihasilkan dapat memberikan calon-calon ayam yang berkualitas.
Patients With Type 2 Diabetes Have an Increased Demand for Pacemaker Treatment: A Comparison With Age- and Sex-Matched Control Subjects From the General Population
Authors: Rautio Elina , Gadler Fredrik , Gudbjörnsdottir Soffia , Franzén Stefan , Rydén Lars , Svensson Ann-Marie , Mellbin Linda G. 
Published: September 2020

OBJECTIVE
Patients with type 2 diabetes have an increased risk for cardiovascular disease, including arrhythmias. The prevalence of bradyarrhythmia and the subsequent need for treatment with pacemakers (PMs) is less well explored in a contemporary patient population. The current study explores 1) whether patients with type 2 diabetes have an increased demand for PM implantation compared with an age- and sex-matched control population without diabetes and 2) patient characteristics associated with an increased demand for receiving a PM.

RESEARCH DESIGN AND METHODS
In this population-matched registry study, a total of 416,247 patients with type 2 diabetes from the Swedish National Diabetes Registry and 2,081,235 age- and sex-matched control subjects selected from the general population were included between 1 January 1998 and 31 December 2012 and followed until 31 December 2013. Mean follow-up time was 7 years. Cox proportional hazards regression analyses were performed to estimate the demand of PM treatment and the factors identifying patients with such demand.

RESULTS
Type 2 diabetes was associated with an increased need of PM treatment (hazard ratio 1.65 [95% CI 1.60–1.69]; P &lt; 0.0001), which remained (1.56 [1.51–1.60]; P &lt; 0.0001) after adjustments for age, sex, educational level, marital status, country of birth, and coronary heart disease. Risk factors for receiving a PM included increasing age, HbA1c, BMI, diabetes duration, and lipid- and blood pressure–lowering medication.

CONCLUSIONS
The need for PM treatment is higher in patients with type 2 diabetes than in matched population-based control subjects. Age, diabetes duration, and HbA1c seem to be risk factors for PM treatment.