bluuebunny/crossref_metadata_2025_split huggingface dataset:
Root architecture for improved resource capture: trade-offs in complex environments
Authors: van der Bom Frederik J T , Williams Alwyn , Bell Michael J 
Published: July 2020

Abstract
Root architecture is a promising breeding target for developing resource-efficient crops. Breeders and plant physiologists have called for root ideotypes that have narrow, deep root systems for improved water and nitrate capture, or wide, shallower root systems for better uptake of less mobile topsoil nutrients such as phosphorus. Yet evidence of relationships between root architecture and crop yield is limited. Many studies focus on the response to a single constraint, despite the fact that crops are frequently exposed to multiple soil constraints. For example, in dryland soils under no-till management, topsoil nutrient stratification is an emergent profile characteristic, leading to spatial separation of water and nutrients as the soil profile dries. This results in spatio-temporal trade-offs between efficient resource capture and pre-defined root ideotypes developed to counter a single constraint. We believe there is need to identify and better understand trade-offs involved in the efficient capture of multiple, spatially disjunct soil resources. Additionally, how these trade-offs interact with genotype (root architecture), environment (soil constraints), and management (agronomy) are critical unknowns. We argue that identifying root traits that enable efficient capture of multiple soil resources under fluctuating environmental constraints is a key step towards meeting the challenges of global food security.
Germany’s integration politics in practice: Lived realities of Chinese-speaking skilled female family migrants
Authors: Hsu Chieh 
Published: July 2020

Abstract
Germany imposes integration-oriented regulations before and after entry on third-country family migrants. However, little attention has been paid to how integration actually unfolds for the subjects of these regulations, usually women, who are situated in the private sphere of the family. This article examines how the concept of integration, a state-anticipated and state-stipulated goal, is connected to the early adaptation of skilled female family migrants who are married to German husbands. Based on participant observation and semi-structured interviews with 21 Chinese-speaking women across Germany, I focus on how these women mobilize resources to overcome ‘hurdles’ of entry requirements, how they define and interpret their tasks and obligation of integration upon arrival, and how the dynamics of their intercultural marriage affect their integration. Viewing these female spousal migrants as subjects in an integration-oriented family migration regime that legitimates intensive integration also in the private sphere, this article highlights these women’s ‘wife’ and ‘migrant’ roles in the family. Specifically, through interactions with their significant others and extended family members, role-related expectations are transferred. The results show that female spouses are consequently exposed to an alternative ideal of integration that is tied to their domestic role. This homebound notion of integration differs from the social integration envisioned and coveted by the German government. This research broadly unveils how these skilled female family migrants’ early acculturation can be seen as a rivalry between pre-established self-conceptions and new circumstances in the host society.
Necrosis and Brain Invasion Predict Radio-Resistance and Tumor Recurrence in Atypical Meningioma: A Retrospective Cohort Study
Authors: Garcia-Segura Monica Emili , Erickson Anders Wilder , Jairath Rishi , Munoz David G , Das Sunit 
Published: July 2020

Abstract

BACKGROUND
Meningiomas are the most common tumors occurring in the central nervous system, with variable recurrence rates depending on World Health Organization grading. Atypical (Grade II) meningioma has a higher rate of recurrence than benign (Grade I) meningioma. The efficacy of adjuvant radiotherapy (RT) to improve tumor control has been questioned.

OBJECTIVE
To investigate clinical and histopathological predictors of tumor recurrence and radio-resistance in atypical meningiomas.

METHODS
This cohort study retrospectively reviewed all patients in St. Michael's Hospital CNS tumor patient database who underwent surgical resection of a Grade II meningioma from 1995 to 2015. Cases with neurofibromatosis type II, multiple satellite tumors, spinal cord meningioma, radiation-induced meningioma, and perioperative death were excluded. Patient demographics, neuropathological diagnosis, tumor location, extent of resection, radiation therapy, and time to recurrence or progression were recorded. Cox univariate regression and Kaplan-Meier survival analysis were employed to identify risk factors for recurrence and radio-resistance.

RESULTS
Among 181 patients, the combination of necrosis and brain invasion was associated with an increased recurrence risk (hazard ratio [HR] = 4.560, P = .001) and the lowest progression-free survival (PFS) relative to other pathological predictors. This trend was maintained after gross total resection (GTR, P = .001). RT was associated with decreased PFS (P = .001), even in patients who received GTR (P = .001).

CONCLUSION
The combination of necrosis and brain invasion is a strong predictor of tumor recurrence and radio-resistance in meningioma, regardless of EOR or adjuvant RT. Our findings question the sensibility of brain invasion as an absolute criterion for Grade II status.
Income and education inequalities in cervical cancer incidence in Canada, 1992–2010
Authors: Morriscey Carol , Hajizadeh Mohammad 
Published: July 2020

ABSTRACT

Background
There is evidence of socioeconomic inequalities in cancer incidence in Canada and other countries globally, yet there is no study investigating socioeconomic inequalities in national cervical cancer incidence in Canada. Thus, the current study investigated income and education inequalities in the incidence of cervical cancer in Canada from 1992 to 2010.

Methods
Data were derived from a linked dataset that combined cervical cancer incidence from the Canadian Cancer Registry and demographic and socioeconomic information from the Canadian Census of Population and the National Household Survey. The Concentration index approach was used to measure income and education inequalities in the incidence of cervical cancer over time.

Results
National incidence of cervical cancer decreased significantly from 1992 to 2010. The age-standardized C was negative for the majority of years for both income and education inequalities, but the preponderance were not significant. Trend analyses of socioeconomic inequalities suggested an increasing concentration of cervical cancer incidence among less-educated females over the study period.

Conclusions
Over almost two decades, there were no pervasive socioeconomic inequalities in the incidence of cervical cancer in Canada. As such, policies aimed at reducing the incidence of cervical cancer should focus on the general population, irrespective of socioeconomic status.
A randomized prospective open-label controlled trial comparing the performance of a connected monitoring interface versus physical routine monitoring in patients with rheumatoid arthritis
Authors: Pers Yves-Marie , Valsecchi Verushka , Mura Thibault , Aouinti Safa , Filippi Nathalie , Marouen Sarah , Letaief Hind , Le Blay Pierre , Autuori Michel , Fournet Dominique , Mercier Grégoire , Ferreira Rosanna , Jorgensen Christian 
Published: July 2020

Abstract

Objectives
In RA, telemedicine may allow tight control of disease activity while reducing hospital visits. We developed a smartphone application connected with a physician’s interface to monitor RA patients. We aimed to assess the performance of this e-Health solution in comparison with routine practice in the management of patients with RA.

Methods
A six-month pragmatic, randomized, controlled, prospective, clinical trial was conducted in RA patients with high to moderate disease activity starting a new DMARD therapy. Two groups were established: ‘connected monitoring’ and ‘conventional monitoring’. The primary outcome was the number of physical visits between baseline and six months. Secondary outcomes included adherence, satisfaction, changes in clinical, functional and health status scores (Short-Form 12).

Results
Of the 94 randomized patients, 89 completed study: 44 in the ‘conventional monitoring’ arm and 45 in the ‘connected monitoring’ arm. The total number of physical visits between required baseline and six-month visits was significantly lower in the ‘connected monitoring’ group [0.42 (0.58) vs 1.93 (0.55); P &lt;0.05]. No differences between groups were observed in the clinical and functional scores. A better quality of life for Short-Form 12 subscores (Role-Physical and Role-Emotional) were found in the ‘connected monitoring’ group.

Conclusion
Our results suggest that connected monitoring reduces the number of physical visits while maintaining a tight control of disease activity and improving quality of life in patients with RA starting a new treatment.

Trial registration
ClinicalTrials.gov, https://clinicaltrials.gov, NCT03005925.
Genetics and the axial spondyloarthritis spectrum
Authors: Brown Matthew A , Xu Huji , Li Zhixiu 
Published: July 2020

Abstract
The axial SpAs (axSpAs) are clearly clinically a heterogeneous set of diseases with markedly varying extra-articular features. These diseases are all highly heritable and have overlapping but differing genetic origins. Shared features include association with HLA class I alleles and genes of the IL-23 pathway, among other things. Significant differences do exist however, both in the genetic loci involved and at specific loci in the individual genetic variants associated with each disease. These similarities and differences are of great interest in regards to disease pathogenesis and treatment development, although individually they are too small in effect to be of prognostic or diagnostic value. Polygenic risk scores, which capture a high proportion of the genetic variation between disorders, have been shown to have clinically useful discriminatory capacity in axSpA. This suggests they have the potential to enable improved disease classification, incorporating basic pathogenic features such as genomics, and ultimately benefitting clinical care. The aim of this article is to review the genetic characteristics of the spectrum of axSpAs and to discuss how this influences our understanding of the disease pathogenesis and the clinical implications of this understanding.
Organoid in colorectal cancer: progress and challenges
Authors: Ji Deng-Bo , Wu Ai-Wen 
Published: July 2020

Abstract
Patient-derived tumor organoids (PDOs) currently represent important modeling tools in pre-clinical investigation of malignancies. Organoid cultures conserve the genetic and phenotypic characteristics of the original tumor and maintain its heterogeneity, allowing their application in many research fields. PDOs derived from colorectal cancer (CRC) have been used for genetic modeling to investigate the function of driver genes. Some researchers have been exploring the value of CRC PDOs in chemotherapy, targeted therapy, and radiotherapy response prediction. The successful generation of PDOs derived from CRC could deepen our understanding of CRC biology and provide novel tools for cancer modeling, for realizing precision medicine by assessing specimens from individual patients ex vivo. The present review discusses recently reported advances in CRC PDOs and the challenges they face as pre-clinical models in CRC research.
Intestinal epithelial chemokine (C-C motif) ligand 7 overexpression protects against high fat diet-induced obesity and hepatic steatosis in mice
Authors: Luo Zhi-Hong , Niu Meng-Wei , Gong Shen-Hai , Wu Guang-Yan , Wang Teng , Wang Fang-Zhao , Wei Guo-Quan , He Zhan-Ke , Jiang Yong , Chen Peng 
Published: July 2020

Abstract

Background
We previously found that the intestinal epithelial chemokine (C-C motif) ligand 7 (CCL7) plays an important role in the development of toxin-induced acute liver damage. The detailed effects of intestinal epithelial CCL7 on chronic diseases; however, are still unclear. Here, we aimed to investigate the impact of intestinal epithelial CCL7 overexpression on high-fat diet (HFD)-induced obesity and steatohepatitis in mice.

Methods
Intestinal epithelial CCL7 overexpression (CCL7

tgIEC

) mice and their wild-type (WT) littermates were fed with normal chow or HFD for 16 weeks to induce obesity and non-alcoholic fatty liver disease. Body weight gain, as well as adipose tissue index were assessed. Liver injury was monitored by histological analysis and real time polymerase chain reaction. Gut microbial composition was analyzed by 16S rRNA gene sequencing.

Results
We found that the CCL7

tgIEC

mice on a HFD had markedly decreased weight gain (8.9 vs. 17.0 g, P < 0.05) and a lower adipose tissue index that include mesenteric fat (1.0% vs. 1.76%, P < 0.05), gonadal fat (2.1% vs. 6.1%, P < 0.05), subcutaneous fat (1.0% vs. 2.8%, P < 0.05) compared to WT animals. HFD-induced glucose intolerance and insulin resistance were also significantly improved in CCL7

tgIEC

mice compared to WT. Furthermore, HFD-fed CCL7

tgIEC

mice displayed less hepatic lipid accumulation and lower expression of inflammatory factors than WT mice. 16S rRNA gene sequencing demonstrated that CCL7 overexpression in intestinal epithelial cells improved HFD-induced gut microbial dysbiosis.

Conclusions
Our study revealed that CCL7 overexpression in the intestinal epithelium protects mice against the progression of diet-induced obesity, hepatic steatosis, and enteric dysbiosis.
Radiological features of traumatic vertebral endplate fracture: an analysis of 194 cases with 263 vertebral fractures
Authors: Wang Xiao-Rong , Xu Fei-Rong , Huang Qiu-Li , Wáng Yì Xiáng J. 
Published: July 2020

Abstract

Background
The importance of identifying osteoporotic vertebral endplate or/and cortex fracture (ECF), which primarily includes endplate fracture (EPF) and vertebral anterior cortex buckling, has been recognized. However, some old traumatic ECFs with healing process in the elderly may be mistaken as osteoporotic. This study analyzes the radiological features of traumatic EPF.

Methods
This was a retrospective analysis of 194 spine trauma patients with 263 vertebral fractures (mean age: 42.11 ± 9.82 years, 118 males and 76 females). All patients had traumatic EPF identified by X-ray/CT/MRI.

Results
The involved vertebra was mostly L1 (29.7%), followed by T12 and L2. Except EPFs involved both superior and inferior endplates (12.6%), only 1.9% involved inferior endplate alone, with the majority involved superior endplate. If each endplate was divided into five segments of equal lengths (from anterior to posterior: a1, a2, m, p2, p1), the most depressed point of superior EPFs was mostly at segment-a2 (approximately 45%), followed by segment-a1 (approximately 20%) or segment-m (approximately 20%), and very rarely at segment-p1. The upper 1/3 of anterior vertebral wall was more likely to fracture, followed by middle 1/3 of anterior wall. For posterior vertebral wall fracture, 68.5% broke the bony wall surrounding the basivertebral vain. 58.6%, 30.0%, and 11.4% of vertebral fractures had <1/5, 1/5–1/3, and >1/3 vertebral body height loss. As the extent of vertebral height loss increased, the chance of having both superior and inferior EPFs also increased; however, the chance of having inferior EPF alone did not increase.

Conclusion
Traumatic EPF features are characterized, which may help the differentiation of traumatic and osteoporotic EPFs.
Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life
Authors: Liu Wan-Ting , Yan Xiu-Xian , Cheng Da-Zhi , Zhang Han-Zi , Ding Ning , Xu Ke-Ming , Zhou Xin-Lin , Chen Qian 
Published: July 2020

Abstract

Background
Benign epilepsy with centrotemporal spikes (BECTS) is the most common type of childhood idiopathic focal epilepsy. BECTS is associated with pervasive cognitive deficits and behavior problems. While seizures can be easily controlled, it is crucial to select anti-epileptic drugs that do not impair cognition, do not cause psychosocial effects, and improve the quality of life. Previous studies showed effects of oxcarbazepine (OXC) monotherapy on the cognitive and psychosocial profiles of patients with BECTS. Here, we studied the effects of OXC monotherapy on the neuropsychologic profiles and quality of life in patients with BECTS in China.

Methods
Thirty-one patients aged 6 to 12 years newly diagnosed with BECTS were recruited. A psychometric assessment was performed before and during the follow-up of OXC monotherapy with Cognitive Computerized Task Battery, Depression Self-Rating Scale for children, Screen for Child Anxiety Related Emotional Disorders, and Quality of Life in Epilepsy-31 (QOLIE-31). The results of the assessments were compared to explore the effect of OXC monotherapy in patients with BECTS.

Results
Thirty children with BECTS completed the study. Five of ten cognitive test scores improved after treatment via OXC monotherapy, including visual tracing (F = 14.480, P < 0.001), paired associated learning (language) (F = 6.292, P < 0.001), paired associated learning (number) (F = 9.721, P < 0.05), word semantic (F = 6.003, P < 0.05), and simple subtraction (F = 6.229, P < 0.05). Of the neuropsychology data concerning the quality of life, statistically significant improvements were observed in emotion (F = 4.946, P < 0.05), QOLIE-social (F = 5.912, P < 0.05), and QOLIE-total (F = 14.161, P < 0.001).

Conclusions
OXC is safe and does not impair neuropsychologic functions, with no obvious mood burden on children with BECTS. Most importantly, OXC has positive impacts on children's perception of quality of life, especially in terms of happiness and life satisfaction.
Potential contribution of the gut microbiota to hypoglycemia after gastric bypass surgery
Authors: Zhou Li-Yuan , Deng Ming-Qun , Xiao Xin-Hua 
Published: July 2020

Abstract
Obesity has become a global health problem. Lifestyle modification and medical treatment only appear to yield short-term weight loss. Roux-en-Y gastric bypass (RYGB) is the most popular bariatric procedure, and it sustains weight reduction and results in the remission of obesity-associated comorbidities for obese individuals. However, patients who undergo this surgery may develop hypoglycemia. To date, the diagnosis is challenging and the prevalence of post-RYGB hypoglycemia (PRH) is unclear. RYGB alters the anatomy of the upper gastrointestinal tract and has a combined effect of caloric intake restriction and nutrient malabsorption. Nevertheless, the physiologic changes after RYGB are complex. Although hyperinsulinemia, incretin effects, dysfunction of β-cells and α-cells, and some other factors have been widely investigated and are reported to be possible mediators of PRH, the pathogenesis is still not completely understood. In light of the important role of the gut microbiome in metabolism, we hypothesized that the gut microbiome might also be a critical link between RYGB and hypoglycemia. In this review, we mainly highlight the current possible factors predisposing individuals to PRH, particularly related to the gut microbiota, which may yield significant insights into the intestinal regulation of glucose metabolic homeostasis and provide novel clues to improve the treatment of type 2 diabetes mellitus.
Mitral regurgitation: a contemporary review of percutaneous mitral valve repair and role of periprocedural imaging
Authors: Beg Faheemullah , Little Stephen H. , Faza Nadeen N. 
Published: July 2020

Purpose of review
This article aims to review recent landmark clinical trials that have resulted in a paradigm shift in the management of patients with mitral regurgitation. This article additionally highlights the instrumental role that structural heart disease (SHD) imaging plays in evaluation of mitral regurgitation and determining candidacy for transcatheter mitral valve repair (TMVr), in addition to the procedural guidance and detection of complications.

Recent findings
Edge-to-edge TMVr with the MitraClip device (Abbott Vascular, Santa Clara, California) was initially studied and subsequently approved by the US Food and Drug Administration (FDA) for treatment of primary mitral regurgitation in 2013. After the publication of a landmark clinical trial in 2018, the indications have been expanded and FDA has subsequently, in 2019, approved TMVr for patients with functional mitral regurgitation. This has been paralleled by advances in cardiac imaging with more emphasis on the role of SHD imagers as a part of the heart team.

Summary
TMVr has revolutionized the management of mitral regurgitation and relies heavily on SHD imaging to ensure optimal outcomes.
The evolving role of coronary artery calcium in preventive cardiology 30 years after the Agatston score
Authors: Kapoor Karan , Cainzos-Achirica Miguel , Nasir Khurram 
Published: July 2020

Purpose of review
On the brink of the 30th anniversary of the Agatston score we summarize the epidemiological data that shaped the recommendations relevant to coronary artery calcium (CAC) included in the 2018/2019 US and European guidelines for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). We also discuss the implications of novel CAC research conducted in asymptomatic populations within the past 2 years.

Recent findings
Based on a wealth of observational evidence, CAC has emerged as a mainstay in personalized risk assessment and is now endorsed as a class IIa tool in both US and European guidelines. In the past 2 years, data supporting the prognostic power of CAC has kept mounting, with longer term follow-up data now available. CAC has been evaluated in a variety of patient populations including individuals with severe hypercholesterolemia, diabetes mellitus and younger adults with family history of ASCVD, in all of whom it may be able to inform a more personalized management. Novel CAC scoring approaches are also discussed.

Summary
Despite a strong endorsement in recent guidelines, active research in the last 2 years has provided further insights on the potential utility of CAC in informing a more individualized preventive management in broader populations.