bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Hypertension Aggravates Vascular Dysfunction After Injury in Male Adult Offspring Through Transgenerational Transmission of N
6
-Methyladenosine
Authors: Zheng Dezhong , Jiang Jiayi , Shen Anna , Zhong Yixiang , Zhang Yi , Xiu Jiancheng 
Published: December 2024

BACKGROUND:
Whether maternal hypertension contributes to the enhanced susceptibility to vascular remodeling in adult offspring through epigenetic mechanisms remains unclear. We aimed to address this gap in the literature using a transgenerational mouse model.

METHODS:

Gestational hypertension was induced in pregnant mice using chronic angiotensin II infusion. Blood pressure was monitored using the tail-cuff method. Two months post-delivery, an N
6
-methyladenosine epitranscriptomic microarray analysis was performed on the carotid arteries of second-generation mice. A unilateral carotid artery injury model was used to study the postinjury vascular response in vivo. Furthermore, carotid ultrasonography, immunohistochemistry, and molecular biological parameters were assessed in adult offspring.

RESULTS:

Exposure to maternal hypertension decreased the birth weight of live pups and increased the fetal death rate. Compared with normal offspring, adult offspring with hypertension had wire-induced injury that led to greater vascular remodeling, which was associated with aggravated inflammation imbalance, fibrosis, and oxidative stress. In addition, aberrant N
6
-methyladenosine methylation, increased N
6
-methyladenosine levels, and increased METTL3 (methyltransferase-like 3) expression were detected in the vessels of offspring with hypertension. Maternal METTL3 deficiency increased the birth weight of live pups with hypertension, improved vascular dysfunction, and alleviated vascular inflammation in adult offspring with hypertension after injury.

CONCLUSIONS:

Maternal hypertension can induce transgenerational transmission of enhanced susceptibility to vascular remodeling, and the possible underlying mechanism is associated with altered METTL3-mediated N
6
-methyladenosine methylation. Therefore, this study reveals the role of epigenetic effects across generations and provides new insights into vascular remodeling causes.
Beyond Derogations in the EU Crisis Regulation
Authors: Tan Nikolas Feith , Ineli-Ciger Meltem 
Published: December 2024

Abstract
The recent Pact on Migration and Asylum, a package of legislative and policy reforms to the European Union (EU) asylum acquis, introduces the concept of expedited procedures for asylum seekers likely to be in need of international protection. These procedures can be implemented under the new Crisis Regulation, which can be triggered in situations of crisis and force majeure. Generally, the Crisis Regulation foresees a range of problematic derogations from the EU asylum system, while the potential use of expedited procedures presents more protective options for granting asylum in crisis and force majeure situations. This article explores the possibility of implementing prima facie or manifestly well-founded procedures under the new Crisis Regulation, arguing for creative, flexible and scaled-up use of expedited procedures, drawing on international practice, to provide fast, fair and efficient procedures to recognise the status of refugees entering the EU in times of crisis.
Challenges for the Protection of Migrant Children
Authors: Vettorel Arianna 
Published: December 2024

Abstract
This paper sheds light on human rights violations suffered by unaccompanied migrant minors in Europe. In fact, notwithstanding the safeguards established by international conventions and European legal provisions (both within the Council of Europe and the European Union), this category of migrants is often not satisfactorily protected by European domestic authorities. This occurs because at times European domestic officers disregard age as attested by foreign official identity documents and because domestic procedures aimed at assessing age are conspicuously carried out in contrast with international and European safeguards, as highlighted by the UN Committee on the Rights of the Child and the European Court of Human Rights. This paper suggests that, even in the lack of an express obligation, a duty to take foreign identity documents into consideration flows from international and European human rights laws; moreover, these legal safeguards should – quite urgently – shape domestic age assessment procedures.
Examining Nigeria’s Commitment to the International Criminal Court: A Response to Anya et al.
Authors: Arinze-Onyia Chuka 
Published: December 2024

Abstract
The International Criminal Court (ICC) plays a key role in ensuring accountability for crimes under international law. Supporting this critical mission of the Court is vital to its survival. Understanding this, Anya et al. in a recent paper examined the relationships existing between states and the ICC. They determine that states can have a relationship of either credible commitment to support the work of the Court or sham devotion. Nigeria, Kenya and Uganda, were studied and based on their analysis of selected data, the writers make predictions for each state’s future engagement with the Court. While the study is compelling, I argue that the predictions made in the end, particularly in relation to Nigeria, are based on flawed data. I attempt to contextualize some of their assertions, particularly regarding immunity, complementarity and jurisdiction. This article ultimately calls for a more nuanced approach to evaluating state behavior towards the ICC, emphasizing the importance of contextual factors beyond quantitative measurements.
Images and Religious History in Italy
Authors: Capriotti Giuseppe 
Published: December 2024

Abstract
The aim of this article is to present historical research conducted by Italian historians and art historians who have treated images as historical sources whose testimonial value is the same as that of written (literary and archival) sources. After a brief introduction into the origins of these methods and the development of the Warburgian approach in Italy, some pioneering works will be examined, followed by a selection of more recent studies by historians and art historians. The latter converge in the shared field of iconographic studies, which function as a dual historiographical periphery, shared by both historians and art historians. Although images have been used to explore different aspects of religious life, this essay will focus on the subtle dynamics of religious conflicts, both among Christians and between Christians, Muslims, and Jews.
Microstructural properties of Pacific yew as determined with SilviScan
Authors: Fox Galen O. , Schimleck Laurence R. 
Published: December 2024

Summary
Pacific yew (Taxus brevifolia Nutt.) is a conifer from the northwestern United States with unusually dense and flexible wood. Because the wood of Pacific yew is not used at scale in the commercial industry, there has been no study of radial variation in wood properties or of the microstructural characteristics responsible for its atypical combination of high density and relatively low stiffness. Increment cores (12.5 mm in diameter) were obtained from 15 Pacific yew trees; SilviScan was used to observe patterns of radial variation in density, microfibril angle (MFA), and stiffness in the cores, and these patterns were compared to other conifer species. Observations included unusually dense wood with uncharacteristically low stiffness, a very slow decrease in density from pith to bark unlike any of the typical patterns of radial density variation reported for other conifers in North America, and an MFA that remained constant at its high initial value of approximately 35 degrees throughout the tree’s lifespan. Microstructural properties and macro characteristics were used to explore the ecological niche into which T. brevifolia fits, as it possesses features not shared by any other species of North American conifer.
5. Melville’s Cancelled Note-to-Self
Authors: Mascia Charles 
Published: December 2024

This chapter explores the genesis of Herman Melville’s unfinished final prose work, the novella Billy Budd. To do so, it relies upon Hayford and Sealts’s Genetic Text Edition, and upon the Fluid Text Edition available on the Melville Electronic Library. Billy Budd tells the story of its titular protagonist, a sailor who is wrongfully accused of mutinous intent and, ultimately, is hanged. In the fragmented sections of its conclusion, Melville enumerates Billy’s afterlife in memory — revealing how variously and incorrectly others judge his innocence and interpret his fate. These final episodes, what Melville called the ‘ragged edge’ of the tale, dramatize the conflicting ways in which a reader might interpret the novella’s events. They focalize narrative unreliability and misreading as the author’s central themes.
Critics have written extensively on this topic, yet have seldom taken into account the text’s own base instability and, at times, incoherence. Incomplete, and corrupted by significant errors and inconsistencies in its manuscript, Melville’s story is not only about narrative disorder, it is also itself a disordered narrative. This chapter undertakes a genetic approach in order to untangle the oversights of an infirm artist from his intentionally ‘ragged’ effects, and to trace how the theme of narrative disarray gradually emerged in the messy process of composition. It argues that Billy Budd’s ‘ragged form’ and dramatization of misreading were not the initial crux of the novella. Rather, they emerged in the final stages of the revision process, as Melville increasingly cultivated textual disorder in the story and made unintentional errors in the manuscript text. I examine three crucial pieces of evidence: mid-stage revisions that replaced the simplicity of his initial coda with a triptych of competing narratives; the late addition of an explicit authorial comment about the inaccessibility of truthful resolution; and a cancelled note-to-self which reveals Melville identifying an unintended inconsistency, the result of his many additions, and choosing to preserve this textual disorder instead of correcting it. The chapter closes by calling for further genetic inquiry into Melville’s earlier, but similarly ‘ragged’ novella, Benito Cereno.
Short-Range Prediction of Squall-Line-Induced Heavy Rainfall: An Added Impact of GPS RO to FY-4A AGRI Data Assimilation
Authors: Xu X. , Zou X. , Yang S. , Li X. 
Published: December 2024

Abstract
The GPS radio occultation technique has prompted a new era as GPS receivers are placed onboard traditional polar-orbiting operational environmental satellites and newly emerging commercial small satellite constellations. With high vertical resolutions of a few hundred meters, GPS radio occultation-observed refractivity profiles effectively complement the geostationary satellite observations of infrared brightness temperatures at high horizontal resolutions (∼2 km) for data assimilation in numerical weather prediction. In this study, numerical experiments are performed to assimilate radio occultation (RO) refractivity observations from FY-3D/FY-3E, MetOp-B/MetOp-C, COSMIC-2, SPIRE, and GeoOptics and brightness temperature observations at channels 9 (6.25 μm) and 10 (7.1 μm) from the Advanced Geosynchronous Radiation Imager (AGRI) onboard FY-4A. The benefits of adding the refractivity to the brightness temperature observations for improving quantitative precipitation forecasts (QPFs) of two squall-line cases over eastern China are shown using the Weather Research and Forecasting Model and the Gridpoint Statistical Interpolation analysis system. In the first case, the squall line was caused by a superposition of cold and dry air advection behind an upper-level trough over low-level warm and humid air by a low-level jet. A combined assimilation of the GPS RO and FY-4A AGRI observations produced a skillful forecast of the squall-line distribution, characterized by a warm zone 100–300-km long ahead of a cold front near the ground; this led to more consistent improvements in the forecast of a narrow band of squall-line thunderstorms than those from two separate assimilations. The threat scores of 24-h QPFs associated with both squall-line cases are significantly improved, especially for heavier rainfall events.
Multiphysics Ensemble Framework for Representing Western Himalayan Precipitation Climatology and Extremes: An Assessment from the WRF Model
Authors: Nischal S. , Attada Raju 
Published: December 2024

Abstract
Numerical model simulations are sensitive to the choice of physical parameterizations, particularly those related to convection processes, especially over complex terrains like the western Himalayan region. This study evaluates the sensitivity of the Weather Research and Forecasting (WRF) Model to three convective parameterization schemes [Betts–Miller–Janjić (BMJ), Kain–Fritsch (KF), and Grell–Freitas (GF)] and their multiphysics ensemble mean (ENSM) through long-term (2001–16) winter (December–March) simulations. Model outputs are validated against multisource datasets [India Meteorological Department (IMD), IMERG, ERA5, and Indian Monsoon Data Assimilation and Analysis (IMDAA)], with extreme precipitation events (EPEs) identified as those exceeding the 95th-percentile threshold. Climatology analysis reveals systematic precipitation biases across all single schemes, significantly reduced in the ENSM. Improvements in skill scores observed for ENSM highlight the reliability of the ensemble approach as an alternative to account for model errors. Underestimations of low-level clouds and hydrometeors improve in ENSM. BMJ and KF (GF) schemes exhibit overestimated (underestimated) magnitudes and location-wise discrepancies for baroclinic instability and moisture transport. These issues are mitigated in ENSM, resulting in better alignment with reference datasets. Additionally, ENSM and KF’s storm tracks align well with reanalyses, while individual schemes show a minor northward placement. For EPEs, ENSM highlights Jammu and Kashmir, Himachal, and Uttarakhand as zones of maximum heavy precipitation and frequency. ENSM realistically represents the western disturbance (WD)-induced circulation characteristics, southward-displaced subtropical jet, shifts in WD-associated vorticity maxima, and potential vorticity intrusions during extremes. Consistent with reference datasets, ENSM demonstrates the crucial role of vertical advection and dynamical controls in moisture distribution during EPEs. Our analysis indicates that a suitable WRF cumulus configuration includes either the multiphysics ENSM or the KF scheme, while the GF scheme yields the poorest results. The findings underscore the importance of evaluating both precipitation characteristics and underlying physical mechanisms to identify sources of systematic biases in model simulations.
Is there a risk of addiction to ketamine during the treatment of depression? A systematic review of available literature
Authors: Ingrosso Gianmarco , Cleare Anthony J , Juruena Mario F 
Published: December 2024

Background: Ketamine has demonstrated both rapid and sustained efficacy in treating depression, especially in treatment-resistant cases. However, concerns regarding the addictive potential of ketamine during long-term depression treatment persist among clinicians. Aim: This review aimed to summarise the evidence on addiction phenomena associated with ketamine treatment of depression. Methods: A comprehensive search was conducted in MEDLINE, Embase, PsycInfo and Global Health databases, with additional relevant studies identified through reference lists. Sixteen studies were included, comprising six randomised controlled trials, three single-arm open-label studies, one retrospective study, three case series and three case reports, for a total of 2174 patients. Results: The studies employed various routes of administration, including intravenous, intramuscular, intranasal, oral and sublingual. Ketamine was administered in the racemic form, except for the studies that utilised intranasal esketamine. Among the included population, four patients were reported to exhibit clear signs of tolerance to the antidepressant effect of ketamine or dependence on the drug, while the majority did not. Cases of addiction phenomena reported in studies that did not meet the inclusion criteria are also discussed. Conclusions: Despite the heterogeneity in study designs and outcome assessment methods, the review underscores the relative safety of ketamine treatment for adult patients with depression, emphasising the importance of medically supervised administration, vigilant monitoring and judicious dosing. Future long-term studies employing quantitative scales to assess dependence phenomena could contribute to strengthening the evidence for the safe and effective use of ketamine in the treatment of depression.
FusionPortableV2: A unified multi-sensor dataset for generalized SLAM across diverse platforms and scalable environments
Authors: Wei Hexiang , Jiao Jianhao , Hu Xiangcheng , Yu Jingwen , Xie Xupeng , Wu Jin , Zhu Yilong , Liu Yuxuan , Wang Lujia , Liu Ming 
Published: December 2024

Simultaneous Localization and Mapping (SLAM) has been widely applied in various robotic missions, from rescue operations to autonomous driving. However, the generalization of SLAM algorithms remains a significant challenge, as current datasets often lack scalability in terms of platforms and environments. To address this limitation, we present FusionPortableV2, a multi-sensor SLAM dataset featuring sensor diversity, varied motion patterns, and a wide range of environmental scenarios. Our dataset comprises 27 sequences, spanning over 2.5 hours and collected from four distinct platforms: a handheld suite, a legged robot, an unmanned ground vehicle (UGV), and a vehicle. These sequences cover diverse settings, including buildings, campuses, and urban areas, with a total length of 38.7 km. Additionally, the dataset includes ground truth (GT) trajectories and RGB point cloud maps covering approximately 0.3 km2. To validate the utility of our dataset in advancing SLAM research, we assess several state-of-the-art (SOTA) SLAM algorithms. Furthermore, we demonstrate the dataset’s broad application beyond traditional SLAM tasks by investigating its potential for monocular depth estimation. The complete dataset, including sensor data, GT, and calibration details, is accessible at https://fusionportable.github.io/dataset/fusionportable_v2 .
Strategic approach to embolization of coronary to pulmonary artery fistulas: a technical note
Authors: Montag Michael Johannes , Möhlenkamp Stefan , von Dohna Martha 
Published: December 2024

Background Congenital coronary artery to pulmonary artery fistulas (CPAFs) are extremely rare congenital vascular malformations. Purpose To give a practical approach and consider technical challenges and pitfalls for endovascular embolization of CPAF. Material and Methods Anatomic, technical, and pathophysiologic considerations are given and demonstrated for antegrade and retrograde endovascular embolization of CPAF. Results Antegrade embolization is easier to perform, saves radiation exposure, and is recommended especially in younger patients. In case of a single dominant feeder, antegrade embolization of this feeder might sufficiently treat the CPAF. Retrograde embolization from the pulmonary orifice is technically more challenging but leads to a complete and definite closure of the fistula in one single step. Conclusion Patient age and fistula configuration must be taken into consideration for appropriate treatment approach in CPAF. Prerequisite for successful embolization of CPAF is profound clinical and interventional experience, why we highly recommend to both plan and carry out embolization of CPAF as interdisciplinary procedure.
Biomimetic niosomal versus liposomal nanoparticle-based aspirin injection for treating stroke and myocardial infarction
Authors: Raj Bhavana , Sapa Harika , Shaji Shona S , Kamalasanan Kaladhar 
Published: December 2024

In this work, we are comparing biomimetic niosomal nanoparticles (BNNs) with biomimetic liposomal nanoparticles (BLNs) and studying their drug carrier properties. A-BNNs and A-BLNs are prepared by lipid hydration method and characterized using DLS for size and zeta potential analysis, surface morphology by SEM, structural details by TEM, crystallinity and phase change by XRD, thermodynamic properties by DSC, TGA and DTGA, drug carrier properties by entrapment efficiency, drug release studies by open-end tube method and its mechanistic assessment by fitting with various models such as zero order, first order, Higuchi and Korsmeyer-Peppas models. The A-BNNs had an average size of 157.0 ± 3.58 nm and A-BLNs had an average size of 173 ± 1.24 nm. The A-BNNs had an average zeta potential of −29.0 ± 1.11 mV and A-BLNs had an average zeta potential of −46.5 ± 1.11 mV. The A-BNNs have an average entrapment efficiency of 94 ± 0.4% and A-BLNs have an average entrapment efficiency of 98 ± 0.14%. The BNNs have an average drug release of 78.12 ± 1.57% and A-BLNs have an average release of 98.41 ± 1.87% over 24 hours. Our results show that the vesicular size dependence influences the resulting nanoparticle drug carrier properties. This is a robust demonstration of the phenomena at the nanoscale that the precursor vesicular system size dependency will be reflected in bulk-engineered nanoparticle properties. These novel nanoparticles are potential candidates for development as an injection to suppress clots in stroke and myocardial infarction.
Acute effects of static stretching on postural control during a maximum forward-leaning task in young and older adults
Authors: Oba Kensuke , Samukawa Mina , Ohta Moeka , Oka Izumi , Kasahara Satoshi , Suzuki Teppei , Ogasawara Katsuhiko 
Published: December 2024

Background Static stretching (SS) is effective in increasing flexibility and neuromuscular function, leading to changes in postural control. Objective This study aimed to examine the acute effects of SS on ankle plantar flexors and dynamic postural control during a maximum forward-leaning task in young and older adults. Methods Twenty-eight university students and 22 community-dwelling older adults were included in this study. The participants performed 5 sets of 1-min SS for the ankle plantar flexors of both legs with standing on a stretching board. Ankle dorsiflexion range of motion (ROM) and center of pressure (COP) during the maximum forward-leaning task, the COP area, and the anterior limit of stability were assessed before and after SS. Results SS increased ankle dorsiflexion ROM, COP velocity, and anterior limit of stability, whereas changes in the COP area were not significant after SS. Furthermore, there were no differences in the changes in postural control between young and older adults, whereas ROM increase was greater in older adults than in young adults. Conclusions These findings suggest that SS can improve postural control and can serve as a simple, low-risk intervention to reduce the risk of falls in older, at-risk adult populations.