bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced analytical methods to assess physical activity behaviour using accelerometer raw time series data: a protocol for a scoping review
Authors: Rastogi Tripti , Backes Anne , Schmitz Susanne , Fagherazzi Guy , van Hees Vincent , Malisoux Laurent 
Published: November 2020

Abstract

Background
Physical activity (PA) is a complex multidimensional human behaviour. Currently, there is no standardised approach for measuring PA using wearable accelerometers in health research. The total volume of PA is an important variable because it includes the frequency, intensity and duration of activity bouts, but it reduces them down to a single summary variable. Therefore, analytical approaches using accelerometer raw time series data taking into account the way PA are accumulated over time may provide more clinically relevant features of physical behaviour. Advances on these fields are highly needed in the context of the rapid development of digital health studies using connected trackers and smartwatches. The objective of this review will be to map advanced analytical approaches and their multidimensional summary variables used to provide a comprehensive picture of PA behaviour.

Methods
This scoping review will be guided by the Arksey and O’Malley methodological framework. A search for relevant publications will be undertaken in MEDLINE (PubMed), Embase and Web of Science databases. The selection of articles will be limited to studies published in English from January 2010 onwards. Studies including analytical methods that go beyond total PA volume, average daily acceleration and the conventional cut-point approaches, involving tri-axial accelerometer data will be included. Two reviewers will independently screen all citations, full-text articles and extract data. The data will be collated, stored and charted to provide a descriptive summary of the analytical methods and outputs, their strengths and limitations and their association with different health outcomes.

Discussion
This protocol describes a systematic method to identify, map and synthesise advanced analytical approaches and their multidimensional summary variables used to investigate PA behaviour and identify potentially clinically relevant features. The results of this review will be useful to guide future research related to analysing PA patterns, investigate their association with health conditions and suggest appropriate recommendations for changes in PA behaviour. The results may be of interest to sports scientists, clinical researchers, epidemiologists and smartphone application developers in the field of PA assessment.

Scoping review registration
This protocol has been registered with the Open Science Framework (OSF): https://osf.io/yxgmb.
Are normoglycaemic individuals at risk of depression? The depression-dysglycaemic phenotype from a European population-based cross-sectional study
Authors: Cuschieri Sarah , Mamo Julian 
Published: November 2020

AbstractBackgroundDepression is a chronic non communicable disease. It is a growing public health concern with established links with a number of co-morbidities, including diabetes mellitus. The study aimed to estimate the prevalence of depression at a population level, establish the depression sub-population phenotypic characteristics while exploring for links between depression and a spectrum of glycemic abnormalities.MethodsA nationally representative cross-sectional study was conducted in Malta between 2014 and 2016. Participants were categorized into different sub-populations according to their glycaemic status. Depression prevalence rates and phenotypic characteristics for each sub-population were established. Multiple regression analysis was performed to identify links with depression.ResultsDepression was prevalent in 17.15% (CI 95%: 16.01–18.36) with a female predominance. Those with known (as opposed to newly diagnosed) diabetes had the highest depression prevalence when compared to other glycemic sub-groups. These also exhibited a significant link with self-reported depression. However, at a population level, depression was mostly prevalent within the normoglycaemic sub-population.ConclusionsThe study confirms the strong link between diabetes and depression, especially, in a high risk dysglycaemic population. Of public health concern is the high depression occurrence within the normoglycaemic sub-population, which attributed for the majority of the Maltese population. In order to reduce the impact of mental health on the population, physicians may consider implementing depression screening clinical tools as part of their routine health check-ups at primary care level, irrespective of the glycaemic status of their patients.
Donor-derived vancomycin-resistant enterococci transmission and bloodstream infection after intestinal transplantation
Authors: Correa-Martínez Carlos L. , Becker Felix , Schwierzeck Vera , Mellmann Alexander , Brockmann Jens G. , Kampmeier Stefanie 
Published: November 2020

Abstract

Background
Transplant recipients are at high risk for infections. However, donor-recipient transmission of multidrug-resistant organisms (MDROs) remains mostly unaddressed in the protocols of pre-transplant infection and colonization screening. Vancomycin-resistant enterococci (VRE) are MDROs that colonize the gastrointestinal tract and are associated with a significant burden of disease. Besides the high mortality of invasive VRE infections, chronic colonization leads to costly isolation measures in the hospital setting. Whereas most post-transplantation VRE infections are endogenous and thus preceded by colonization of the recipient, conclusive evidence of VRE transmission via allograft in the context of intestinal transplantation is lacking.

Case presentation
We describe a donor-derived VRE infection after intestinal transplantation including small bowel and right hemicolon. The recipient, a 54-year old male with history of mesenteric ischemia and small bowel perforation due to generalized atherosclerosis and chronic stenosis of the celiac trunk and the superior mesenteric artery, developed an intra-abdominal infection and bloodstream infection after transplantation. VRE isolates recovered from the patient as well as from the allograft prior to transplantation were analyzed via whole genome sequencing. Isolates showed to be genetically identical, thus confirming the transmission from donor to recipient.

Conclusions
This case underlines the relevance of donor-recipient VRE transmission and invasive infection in the context of intestinal transplantation, highlighting the need for preoperative MDRO screening that facilitates the prompt and effective treatment of possible infections as well as the timely establishment of contact precautions to prevent further spread.
Antimicrobial use in food animals and human health: time to implement ‘One Health’ approach
Authors: Pokharel Sunil , Shrestha Priyanka , Adhikari Bipin 
Published: November 2020

Abstract
The use of antimicrobials in animals for growth promotion and infection prevention significantly contributes to the development of antimicrobial resistance (AMR), a growing public health threat. While the World Health Organization (WHO), the United Nations (UN) and the European Union (EU) have taken steps towards reducing and restricting the use of antimicrobials in animals, initiatives are insufficient in developing countries where the demands for food animals continue to rise over the years. The inter-sectoral acknowledgment of inextricable link between animal health, human health and the environment (One Health approach) is critical. Concerted and collaborative efforts among all the stakeholders are essential to deal with this complex problem of resistance.
COVID-19: through the eyes through the front line, an international perspective
Authors: Kavanagh Kevin T. , Pare Judith , Pontus Christine 
Published: November 2020

Abstract
COVID-19 is continuing to ravage the globe. In many Western Countries, the populous has not embraced public health advice which has resulted in a resurgence of the COVID-19 virus. In the United States, there is an absence of a coordinated Federal response. Instead, frontline workers and average citizens are having to cope with extensive mixed messaging regarding mask usage and social distancing from the highest levels of government. This has resulted in the United States not being able to achieve a low level of infection since the pandemic began. In addition, many citizens hold a profound belief that individual freedoms must be preserved, even at the expense of public health; and view the wearing of masks as renouncing this right. These engrained political beliefs can be traced back to the late 1800s. The response of the United States has also been hampered by a highly cost-efficient healthcare system, which does not provide universal care and has a just-in-time supply chain, with far too few supplies in reserve. This efficiency prevented a rapid scaling up of the healthcare response, which resulted in severe deficiencies in available personal protective equipment (PPE) and healthcare staff. To compound issues many healthcare staff are not provided an economic or healthcare safety net. Other frontline workers, such as those who work in transportation and food services, are working under even greater adversities. Many of these workers are from diverse backgrounds, who, along with their families, are at even greater risk for COVID-19. This vulnerable population of frontline workers are faced with a choice of going to work with inadequate PPE or placing food on their families’ table. In the United States, official recommendations seem to be ever changing, based more upon supply and test availability, than on science. We must rely on science and learn from the lessons of past pandemics or we will relive, even to a greater degree, the deaths and devastations experienced by our ancestors over 100 years ago.
Adolescents’ mental health concerns, reported with an idiographic assessment tool
Authors: Tollefsen Thomas Kristian , Darrow Sabrina Michelle , Neumer Simon-Peter , Berg-Nielsen Turid Suzanne 
Published: November 2020

Abstract

Background
Adolescents’ self-defined concerns about their mental health are understudied. Yet gaining insight into the individual concerns of this group could be helpful in providing better services to the adolescent population. In this study, an idiographic procedure called Assert was used to increase our knowledge of which concerns are reported by adolescents as the most salient, in a primary mental health care situation.

Method
231 unique concerns were reported by 70 adolescents in a primary mental health context in Norway. These concerns were analysed qualitatively by a group of experts, to define categories. The distribution of these categories, and differences in gender and age, were analysed quantitatively. The alleviation experienced on the subjective concerns over the course of counselling was measured. Two linear multilevel models were analysed, to examine whether alleviation on self-defined concerns, as measured with Assert, differed-based on the main category of the concern or the number of times Assert was used.

Results
Three main categories of concerns emerged, related to (1) Self, (2) Relationships and (3) Life domains; as well as nine sub-categories: (1a) Autonomy, (1b) Mental health, (1c) Somatic health, (2a) Improving of relationships, (2b) Feeling safe from people around them, (2c) Taking responsibility for others, (3a) School, (3b) Work and (3c) Spare time. Girls reported fewer Life domain concerns than boys. Younger adolescents (12–16) more frequently reported no Self concerns, and older adolescents (17–23) more frequently reported no Relationship concerns. The adolescents felt less bothered by their subjective concerns after counselling, and there were some differences in alleviation depending on the category of concern.

Conclusions
The adolescents defined their own concerns at the start of counselling and were less troubled by these concerns after counselling. The content of the concerns might suggest that these adolescents experienced a need to improve across several arenas: personal, relational and academic. Research to extend the current study, to understand individual adolescent concerns, should include contextual and social factors and personal characteristics—and explore how counselling interventions can best help alleviate these personal concerns.
Rebuild of the Bulletin of the International Seismological Centre (ISC)—part 2: 1980–2010
Authors: Storchak Dmitry A. , Harris James , Brown Lonn , Lieser Kathrin , Shumba Blessing , Di Giacomo Domenico 
Published: November 2020

AbstractThe Bulletin of the International Seismological Centre (ISC) remains in demand for a wide range of geophysical studies. Users of the ISC Bulletin benefit from its long-term coverage, the most comprehensive set of measurements from the majority of permanent seismic stations and networks, and homogeneity of included parameters of earthquakes and other seismic events worldwide. Despite a reasonably conservative approach in preserving the operational procedures, changes are inevitable in order to achieve the best possible accuracy of published earthquake parameters. The last fundamental change in procedures has fully affected the data for years 2011 and beyond (Bondár and Storchak in Geophys J Int 186: 1220-1244, 2011). This is why it was decided to rebuild the earlier part (1964–2010) of the ISC Bulletin to achieve compatibility in earthquake hypocentres and magnitudes through its entire period. The first article on this project (Storchak et al. in Geosci Lett 4: 32, 2017) covered the period from 1964 to 1979, as it was publicly released. This article covers the remaining period from 1980 to 2010 with all seismic events re-processed and re-located in line with the modern ISC procedures, with ~ 489,000 new events, ~ 2600 new stations, ~15.5 million new seismic arrivals, and more robust and reliablembandMSmagnitude evaluations. We give statistics of departures in epicentre location and depth between the original and rebuilt ISC hypocentres. We also provide a summary for the entire rebuilt period (1964–2010). We give a brief account of events deleted from and added to the Bulletin, based on additional reports from permanent and temporary seismic deployments. We explain that newly re-computed (rebuilt)mbis on average larger that the originalmbby 0.05 unit of magnitude. The rebuiltMSis only 0.01 unit larger that its predecessor. We announce that the entire reviewed part of the ISC Bulletin (1964–2017) is now based on the same velocity model,ak135,and the same earthquake location and magnitude computation procedures. Finally, we provide advice on how to obtain the original ISC Bulletin data, where necessary.
Effects of environmental distractors on nurse emergency triage accuracy: a pilot study protocol
Authors: Delmas Philippe , Fiorentino Assunta , Antonini Matteo , Vuilleumier Séverine , Stotzer Guy , Kollbrunner Aurélien , Jaccard Dominique , Hulaas Jarle , Rutschmann Olivier , Simon Josette , Hugli Olivier , Gilart de Keranflec’h Charlotte , Pasquier Jérome 
Published: November 2020

Abstract

Background
The clinical decisions of emergency department triage nurses need to be of the highest accuracy. However, studies have found repeatedly that these nurses over- or underestimate the severity of patient health conditions. This has major consequences for patient safety and patient flow management. Workplace distractors such as noise and task interruptions have been pointed to as factors that might explain this inaccuracy. The use of a serious game reproducing the work environment during triage affords the opportunity to explore the impact of these distractors on nurse emergency triage accuracy, in a safe setting.

Methods/design
A pilot study with a factorial design will be carried out to test the acceptability and feasibility of a serious game developed specifically to simulate the triage process in emergency departments and to explore the primary effects of distractors on nurse emergency triage accuracy. Eighty emergency nurses will be randomized into four groups: three groups exposed to different distractors (A, noise; B, task interruptions; C, noise and task interruptions) and one control group. All nurses will have to complete 20 clinical vignettes within 2 h. For each vignette, a gold standard assessment will be determined by experts. Pre-tests will be conducted with clinicians and certified emergency nurses to evaluate the appeal of the serious game.

Discussion
Study results will inform the design of large-scale investigations and will help identify teaching, training, and research areas that require further development.
Transdiagnostic group cognitive behaviour therapy for anxiety in bipolar disorder—a pilot feasibility and acceptability study
Authors: Perich Tania , Mitchell Philip B. , Meade Tanya 
Published: November 2020

Abstract
Objective
Anxiety is prominent for many people living with bipolar disorder, yet the benefit of psychological interventions in treating this co-morbidity has been minimally explored and few studies have been conducted in a group format. This study aimed to assess the feasibility and acceptability of a transdiagnostic cognitive behaviour therapy group anxiety programme (CBTA-BD) for people living with bipolar disorder.

Methods
Participants were recruited to take part in a 9-week group therapy programme designed to treat anxiety in bipolar disorder using cognitive behaviour therapy. They were assessed by structured interview (SCID-5 RV) to confirm the diagnosis of bipolar disorder and assessed for anxiety disorders. Self-report questionnaires—DASS (depression, anxiety, stress), ASRM (mania), STAI (state and trait anxiety) and Brief QOL.BD (quality of life) pre- and post-treatment were administered.

Results
Fourteen participants enrolled in the programme, with 10 participants (5 male; 5 female) completing the follow-up assessments. Two groups (one during working hours, the other outside working hours) were conducted. The programme appeared acceptable and feasible with a mean of 6.9 (77%) sessions attended, though five (50%) participants completed less than 3 weeks homework.

Conclusion
The transdiagnostic cognitive behaviour therapy group anxiety programme (CBTA-BD) proved feasible and acceptable for participants; however, homework compliance was poor. A larger randomised pilot study is needed to assess the benefits of the intervention on symptom measures and address homework adherence, possibly through providing support between sessions or tailoring it more specifically to participant needs.
Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats
Authors: Athesh Kumaraswamy , Sivasubramanian Rangaraju , Jothi Gnanasekaran , Brindha Pemiah 
Published: November 2020

AbstractBackgroundObesity, reached epidemic proportions globally is often associated with life threatening comorbidities. The unavailability of safe and effective long term medications for obesity in modern pharmacotherapy forces the scientific community to explore the potential of Ayurvedic traditional healers as they are considered safe and effective.ObjectiveTo explore the anti-obesity potential of aqueous extract of aerial parts ofAchyranthes asperaL. (AEAA), a traditional healer in high fat diet (HFD) induced obese rats.MethodsAEAA was prepared and subjected to in-vitro pancreatic lipase inhibition assay and in-vivo anti-obesity studies. For in-vivo studies, HFD fed obese prone Wistar albino rats were divided into five experimental groups (Group II to VI): animals fed with standard pellet chow served as normal control (Group I) while, animals continued with HFD alone served as obese control (Group II); Group III, IV and V were administered AEAA at a dose of 100, 200 and 300 mg/kg b.w. respectively along with HFD; and animals administered orlistat (30 mg/kg bw) along with HFD served as standard control (Group VI). All the drugs were administered orally once a day for a period of 60 days. At the end of the experimental period various physical, biochemical and histopathological observations were made.ResultsIn-vitro studies showed AEAA partially but not significantly inhibited the activity of pancreatic lipase. Data of in-vivo studies revealed, significant reduction in body weights, fat pad weights and organ weights upon AEAA treatment. Elevated levels of glucose, insulin, leptin, lipid profiles and antioxidant status were also brought back to normal.ConclusionThe obtained results clearly suggested that AEAA possess pronounced anti-obesity potential.
Syrian refugees’ perspectives and service providers’ viewpoints on major needs and future plans in Jordan
Authors: Naseh Mitra , Liviero Natalia , Rafieifar Maryam , Abtahi Zahra , Potocky Miriam 
Published: November 2020

Abstract
The ongoing civil war in Syria created the world’s largest refugee crisis since World War II. As exile continues for many Syrians, this study aimed to explore what refugees perceive as their major needs and plans for the future in comparison to what service providers believe is needed and should be planned in Jordan. Phenomenological design and inductive reasoning were used in this study to explore refugees’ needs and future plans from the etic view by interviewing key informants and from the emic view by analyzing interviews with refugees. After coding and comparing the key informants’ interviews and refugees’ narratives, six main themes emerged: (1) gap between refugees’ expectations and reality of humanitarian services; (2) rent as a major but neglected challenge; (3) older adults: vulnerable and at the back of the queue for services; (4) mental health of adults as an overlooked need; (5) education: hard to access for extremely poor and adults; and (6) an uncertain and unplanned future. Findings suggest a need for better information sharing strategies about services, targeted programs for urbane refugees and older adults, awareness-raising about importance of the mental health and protracted exile, and long-term planning.
The centenary of Hereditas - almost a fairytale
Authors: Shi Yongyong , Baumgartner Stefan 
Published: November 2020

Abstract
This is the Editorial for a series of articles illuminating the history and success story of Hereditas, one of the oldest journals in the area of genetics. For this reason, we invite you to read this special series on a journal with a distinct reputation and which can celebrate its Centenary in 2020.