bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare Initial Manifestation of Lupus as Lobular Panniculitis of the Breast—A Case Report and Review of the Literature
Authors: Sharma Anurag , Blank Alexander , Komforti Miglena K. 
Published: November 2020

Abstract:
Lupus mastitis is a rare complication of systemic or discoid lupus erythematosus with an uncommon initial presentation when limited to the breast. In this article, we report a 42-year-old woman who presented with constant pain and tenderness in her breasts. Ultrasound imaging of the left breast revealed a 14-mm oval mass, suspicious for malignancy; a needle core biopsy was performed. Sections showed necrosis of the fat lobules with associated mixed nodular lymphoplasmacytic aggregates. Karyorrhectic debris, fibrinoid necrosis of small vessels, and microcalcifications were all present while the background breast parenchyma was unremarkable. The diagnosis of lupus mastitis was rendered. Subsequent serology showed negative dsDNA but positive antinuclear antibodies, C4, and anti -Sjögren’;s-syndrome-related antigen A antibodies. Clinical features of active systemic disease were not identified at the patient's follow-up dermatology appointment 1 month after the biopsy, and she elected management for her nodules with steroids. To the best of our knowledge, only 40 other cases of lupus mastitis have been reported in the English literature, of which 25 presented as a mass and only in 6 lupus mastitis of the breast was the initial presentation. In conclusion, we bring much needed awareness to lupus mastitis as the first presentation of disease.
Comparative efficacy and safety of traditional Chinese medicine for lipodermatosclerosis
Authors: Du Mengmeng , Zhang Yudong , Shi Xiaohua , Liu Ming 
Published: November 2020

Abstract

Background:
Lipodermatosclerosis (LDS) is a severe skin change accompanied by the development of chronic venous disease of the lower extremities. Its main clinical manifestations are erythema, induration, hyperpigmentation, and rough and thickened skin. It may also eventually lead to refractory ulcers, skin necrosis and even cancer. Conventional treatment methods mainly include the intake of oral anabolic hormones or androgen and pressure therapy. However, patients often refuse due to their drug resistance and intolerance. As a clinical irreplaceable treatment method for LDS, traditional Chinese medicine (TCM) has not been compared of the safety and effectiveness so far. Therefore, we cannot wait to use a method to compare the efficacy of TCM for LDS systematically, such as network meta-analysis (NMA).

Methods:
We will retrieve the relevant Chinese and English databases comprehensively. All the randomized controlled trials of TCM for LDS from January 2015 to September 2020 will be included. Under the guidance of inclusion criteria, 2 researchers will screen the literature, then assess the risk of bias and extract data. We will use Bayesian NMA to evaluate all available evidence in STATA 14.0 and WinBUGS software.

Results:
This study will use Bayesian NMA to evaluate the efficacy and safety of TCM for LDS.

Conclusion:
This study provide a reliable theoretical basis for the clinical application of TCM in the treatment of LDS, and contribute to the formulation of treatment guidelines for LDS.
World War II cohorts and diabetes mellitus, coronary heart disease and cerebrovascular disease later in life: An observational cohort study based on German claims data
Authors: Fritze Thomas , Reinke Constantin , van den Berg Gerard J. , Doblhammer Gabriele 
Published: November 2020

AbstractBackgroundThis study applied a data-driven approach to explore whether being born during or around World War II affects the risk of morbidity later in life.MethodsIncident diagnoses were explored for diabetes (ICD-10 code E10-E14; 75,487 persons/12,905 incident cases), cerebrovascular disease (CeVD; I6; 79,829/11,664), and coronary heart disease (CHD; I20-I25; 89,657/11,116) for birth cohorts 1935-1950, using German health-claims data from 2004-2015. The data include quarterly information of the inpatient and outpatient treatment. We applied recursive partitioning methods with the aim of splitting the sample into birth cohorts with different risk profiles in terms of the incidence of diabetes, CeVD, and CHD. We performed Cox proportional hazard models to explore the transition into diabetes, CeVD, and CHD, accounting for birth cohort and gender. We used the median cut-points from the recursive partitioning analysis on the birth cohort indicator to define linear splines and present the yearly slopes of the linear splines.ResultsBased on the results from recursive partitioning method we defined four groups of birth cohorts depending on the disease of interest (diabetes: 1/35-10/37, 11/37-11/41, 12/41-10/44, 11/44-12/50; CHD: 1/35-5/37, 6/37-4/41, 10/44-12/50; CeVD: 1/35-6/37, 7/37-6/40, 7/40-12/43, 1/44-12/50). We found a general decline in cohort incidence for all three diseases, however, there was a discontinuation for diabetes among birth cohorts 12/41-10/44 (yearly slope=-0.01, p=0.584), and a deceleration for cohorts 11/44-12/50 for CeVD.ConclusionsWe identified risk periods associated with WWII that interfered with the cohort decline in the risk of diabetes and CeVD, stressing the importance of a beneficial early-life environment.Availability of dataThe scientific research institute of the AOK (WIdO) has strict rules regarding data sharing because of the fact that health claims data are a sensible data source and have ethical restrictions imposed due to concerns regarding privacy. Anonymized data are available to all interested researchers upon request. Interested individuals or an institution who wish to request access to the health claims data of the AOK, please contact the WIdO (webpage: http://www.wido.de/, mail: wido@wido.bv.aok.de).
A bibliometric analysis of the highest cited and highest category normalised articles in radiological literature from 2009-2019
Authors: McKay Parry Nicholas , Rich Justin , Erian Michael , Lloyd Thomas 
Published: November 2020

AbstractRationale and ObjectiveCitation-based metrics are frequently used to evaluate the academic performance of a publication. One such metric is the number of citations an article receives, however this is not an infallible index. To account for biases of this metric the category-normalised citation index (CNCI), termed ‘impact’, may be used. Here the 100 highest-cited and highest-CNCI articles in radiological literature, from 2009 – 2019 is performed.Materials and MethodsThe Web of Science Core Collection and InCites (Clarivate Analytics) databases were accessed for the citations and CNCI values for articles published in the 186 journals with category “radiology, nuclear medicine, and medical imaging” between 2009 and 2019. The top 100 articles with the highest citation count and highest CNCI values were collected. Article parameters were analysed including title, year of publication, citation count, CNCI, field of study and modality studied were analysed.ResultsFifty-three articles were common to both lists. Neuroradiology was the most prevalent subspecialty studied in both the highest-cited (n = 68) and highest-impact (n = 41) lists, respectively. The most frequently utilised imaging modality was magnetic resonance imaging (n = 64 and 40). The highest-CNCI articles demonstrated greater variability and distribution across subspecialties, imaging modalities and year of publication when compared to the highest-cited list.ConclusionThe use of normalised bibliometric analysis tools may remove bias when evaluating research and better demonstrate the breadth of research activity. Use of these tools may provide a more robust and contemporaneous review of the landscape of research within a field.
Demystifying the spreading of pandemics I: The fractal kinetics SI model quantifies the dynamics of COVID-19
Authors: Macheras Panos , Kosmidis Kosmas , Chryssafidis Pavlos 
Published: November 2020

AbstractThe COVID-19 pandemic has created a public health crisis. The recently developed fractal kinetics susceptible-infected model was used for the analysis of the first COVID-19 wave data. The model was found to be in excellent agreement with the data. The “fractal” exponent of time is critical for the kinetics of the disease spreading since it captures the impact of the spatial related factors e.g. lockdowns, masks on the virus transmission. Estimates of the model parameters were derived from the epidemiological data of France, Greece, Italy and Spain. A universal law was established between the “fractal” exponent and the “apparent transmissibility constant” of the model. 173 countries were classified according to the fractal exponent and the asymptotic limit of the cumulative fraction of infected individuals.
Enabling integrated business planning through big data analytics: a case study on sales and operations planning
Authors: Schlegel Alexander , Birkel Hendrik Sebastian , Hartmann Evi 
Published: November 2020

PurposeThe purpose of this study is to investigate how big data analytics capabilities (BDAC) enable the implementation of integrated business planning (IBP) – the advanced form of sales and operations planning (S&OP) – by counteracting the increasing information processing requirements.Design/methodology/approachThe research model is grounded in the organizational information processing theory (OIPT). An embedded single case study on a multinational agrochemical company with multiple geographically distinguished sub-units of analysis was conducted. Data were collected in workshops, semistructured interviews as well as direct observations and enriched by secondary data from internal company sources as well as publicly available sources.FindingsThe results show the relevancy of establishing BDAC within an organization to apply IBP by providing empirical evidence of BDA solutions in S&OP. The study highlights how BDAC increase an organization's information processing capacity and consequently enable efficient and effective S&OP. Practical guidance toward the development of tangible, human and intangible BDAC in a particular sequence is given.Originality/valueThis study is the first theoretically grounded, empirical investigation of S&OP implementation journeys under consideration of the impact of BDAC.
Evaluation of the IR Biotyper for Klebsiella pneumoniae typing and its potentials in hospital hygiene management
Authors: Hu Yanyan , Zhou Hongwei , Lu Jiayue , Sun Qiaoling , Liu Congcong , Zeng Yu , Zhang Rong 
Published: November 2020

SummaryKlebsiella pneumoniae has emerged as one of the most important pathogens that frequently encounter in community‐acquired or hospital‐acquired infections. Timely epidemiological surveillance could greatly facilitate infection control of K. pneumoniae and many deadly pathogens alike. In this study, we evaluated the performance of the IR Biotyper, a Fourier transform infrared (FTIR) spectroscopy system for K. pneumoniae isolates typing through (i) optimizing the culture scheme and defining the cutoff value (COV) range and (ii) comparing with commonly used typing tools such as multi‐locus sequence typing (MLST), pulsed‐field gel electrophoresis (PFGE) and whole‐genome sequencing (WGS). We found that a non‐selective and non‐chromogenic medium with 24 ± 2 h incubation gives the best discriminatory power for the IR Biotyper (IRBT). COV evaluation indicated that the IRBT is a robust typing method with good reproducibility. Besides, we observed that the modified H2O‐EtOH suspensions preparation method could enhance the quality of the spectrum, especially for those hypermucoviscous strains. For the method comparison study, our data demonstrated that FTIR spectroscopy could accurately cluster K. pneumoniae strains. The typing results of the IRBT were almost entirely in concordance with those from PFGE and WGS. Together with the advantages such as low costs and short turnaround time (less than 3h), the IRBT is a promising tool for strain typing that could make real‐time outbreak investigation a reality.
Sepsis after elective surgery – Incidence, aetiology and outcome
Authors: Vesteinsdottir Edda , Gottfredsson Magnus , Blondal Asbjorn , Sigurdsson Martin I. , Karason Sigurbergur 
Published: November 2020

BackgroundSepsis requiring admission to intensive care (ICU) is a rare complication of elective surgery, but is associated with high morbidity and mortality. The aim of this study was to describe the incidence and outcome of sepsis following elective surgery.MethodsThis was a retrospective, observational study where all admissions to Icelandic ICUs during calendar years 2006, 2008, 2010, 2012, 2014 and 2016 were screened, identifing patients with sepsis following elective surgery (ACCP/SCCM criteria). The number of elective operations performed at the largest center (Landspitali) during the study years were collected. Descriptive statistics were used to assess the incidence and outcome of patients with sepsis after elective surgery.ResultsDuring the study years, 88 patients were admitted to Icelandic ICUs with sepsis following elective surgery. Of those, 80 were operated at Landspitali, where the incidence of sepsis was 0.19% per elective procedure, highest following pancreaticoduodenectomies (14%, CI 6‐25) and esophagectomies (13%, CI 4‐27), but the greatest number of patients (30% (26/88)) developed sepsis after a colorectal procedure. The most common infection sources were the abdomen (65% (57/88)) and lungs/mediastinum (22% (19/88)), frequently polymicrobial (58% (36/62) of patients with cultures). The incidence of insufficient empirical antibiotics was high (50% (30/60)). The median ICU and hospital length‐of‐stay were 5.5 and 26 days and the 28‐day and 1‐year mortality rates were 16% (14/88) and 41% (36/87), respectively.ConclusionsIncidence of sepsis following elective surgery is low in Iceland but mortality is high. Initial antimicrobial therapy needs careful consideration in these hospital‐acquired, often polymicrobial infections.
Next steps in dismantling discrimination: Lessons from ecology and conservation science
Authors: Chaudhury Aadita , Colla Sheila 
Published: November 2020

AbstractEcology, conservation, and other scientific disciplines have histories built on the oppression of marginalized groups of people. Modern day discrimination continues in these fields and there is renewed interest in dismantling these system of oppression. In this paper, we offer some examples of historical events which have shaped the field and argue that reckoning with colonial histories is part of the process to dismantle discrimination and achieve equity and inclusion. We discuss ways forward including incorporating different knowledge systems and reflecting on one's own biases and privilege. To truly achieve fields of science which are just, diverse, and equitable will be one of our greatest challenges, but one that is necessary to protect our environment, an endeavor which cannot be detangled from societal injustices.
Transcriptome analysis of a ring chromosome 20 patient cohort
Authors: Myers Kenneth A. , Bennett Mark F. , Hildebrand Michael S. , Coleman Matthew J. , Zhou Geyu , Hollingsworth Georgie , Cairns Anita , Riney Kate , Berkovic Samuel F. , Bahlo Melanie , Scheffer Ingrid E. 
Published: November 2020

AbstractRing chromosomes occur when the ends of normally rod‐shaped chromosomes fuse. In ring chromosome 20 (ring 20), intellectual disability and epilepsy are usually present, even if there is no deleted coding material; the mechanism by which individuals with complete ring chromosomes develop seizures and other phenotypic abnormalities is not understood. We investigated altered gene transcription as a contributing factor by performing RNA‐sequencing (RNA‐seq) analysis on blood from seven patients with ring 20, and 11 first‐degree relatives (all parents). Geographic analysis did not identify altered expression in peritelomeric or other specific chromosome 20 regions. RNA‐seq analysis revealed 97 genes potentially differentially expressed in ring 20 patients. These included one epilepsy gene, NPRL3, but this finding was not confirmed on reverse transcription Droplet Digital polymerase chain reaction analysis. Molecular studies of structural chromosomal anomalies such as ring chromosome are challenging and often difficult to interpret because many patients are mosaic, and there may be genome‐wide chromosomal instability affecting gene expression. Our findings nevertheless suggest that peritelomeric altered transcription is not the likely pathogenic mechanism in ring 20. Underlying genetic mechanisms are likely complex and may involve differential expression of many genes, the majority of which may not be located on chromosome 20.
A rapid detection of Escherichia coli O157:H7 by competition visual antigen macroarray
Authors: Xia Junfang , Qiu Shi , Zeng Haijuan , Liu Cheng , Liu Qing 
Published: November 2020

AbstractPathogenic bacterial contamination is a serious problem for the food industry and in public health. Rapid, accurate and affordable testing for pathogenic bacterial strains is desirable. In this study, a competition visual antigen macroarray (CVAM) for rapid detection of Escherichia coli O157:H7 (E. coli O157:H7) has been developed. This array was able to utilize an HRP‐labeled anti‐E. coli O157:H7 MAb at a concentration of 1:20000 while having a similar sensitivity of 10 5 CFU/ml for E. coli O157:H7 detection as double antibody sandwich array and conventional ELISA. The detection time of CVAM was short as 2 h and can be examined directly by the naked eye. Moreover, there was no cross‐reactivity in the detection of tested in this study. Application of CVAM for the detection of E. coli O157:H7 artificially contaminated milk samples was feasible that showed the antigen array could be applied in the detection of food pathogen infections.
Correspondence between physiological and behavioural responses to vibratory stimuli during the sleep onset period: A quantitative electroencephalography analysis
Authors: Scott Hannah , Lechat Bastien , Lovato Nicole , Lack Leon 
Published: November 2020

AbstractBehavioural responses to auditory stimuli cease in late N1 or early N2 sleep. Yet, responsiveness to minimal intensity tactile stimuli and the correspondence with sleep microstructure during the sleep onset period is unknown. The aim of the present study was to investigate sleep microstructure using quantitative electroencephalography analysis when participants behaviourally responded to minimal intensity vibratory stimuli compared to when participants did not respond to stimuli during the sleep onset period. Eighteen participants wore a device that emitted vibratory stimuli to which individuals responded by tapping their index finger. A fast Fourier transform using multitaper‐based estimation was applied to electroencephalography signals in 5‐s epochs. Participants exhibited increases in higher frequencies 5 s before and immediately after the stimulus presentation when they responded to the stimulus compared to when they did not respond during all sleep stages. They also had greater delta power after stimulus onset when they did not respond to stimuli presented in N1 and N2 sleep compared to when they did respond. Participants responded to a significantly greater proportion of stimuli in wake than in N1 sleep (p < .001, d = 2.38), which was also significantly greater than the proportion of responses in N2 sleep (p < .001, d = 1.12). Participants showed wake‐like sleep microstructure when they responded to vibratory stimuli and sleep‐like microstructure when they did not respond during all sleep stages. The present study adds to the body of evidence characterising N1 sleep as a transitional period between sleep and wake containing rapid fluctuations between these two states.
Detection of circulating tumour cells enables early recurrence prediction in hepatocellular carcinoma patients undergoing liver transplantation
Authors: Wang Peng‐Xiang , Xu Yang , Sun Yun‐Fan , Cheng Jian‐Wen , Zhou Kai‐Qian , Wu Sui‐Yi , Hu Bo , Zhang Ze‐Fan , Guo Wei , Cao Ya , Huang Xiao‐Wu , Zhou Jian , Fan Jia , Yang Xin‐Rong 
Published: November 2020

AbstractBackground & AimsLiver transplantation (LTx) is one of the most effective treatments for hepatocellular carcinoma (HCC); however, tumour recurrence after LTx often leads to poor outcomes. This study investigated the value of circulating tumour cells (CTCs) as a predictor of recurrence following LTx in patients with HCC.MethodsThis analysis included 193 patients with HCC who underwent LTx at our institute and accepted pre‐ and post‐operative CTC detection; 38 were selected for serial CTC monitoring. The predictive value of CTCs for tumour recurrence in patients with HCC following LTx was evaluated. Single‐cell whole genome sequencing was used to characterize CTCs.ResultsOverall, the CTC burden decreased after LTx (P < .05). Post‐operative CTC count ≥ 1 per 5 mL peripheral blood was identified as a potential biomarker for predicting tumour recurrence after LTx, especially in patients with no detectable CTCs prior to LTx and negative tumour serological biomarkers. The predictive value of post‐operative CTC count ≥ 1 per 5 mL blood was retained in patients who did not meet the Milan criteria, University of California San Francisco (UCSF) criteria, or Fudan criteria (all P < .05). Furthermore, post‐operative serial CTC detection may be useful in post‐surgical surveillance for HCC recurrence.ConclusionsCTCs may be a useful biomarker to evaluate recurrence risk following LTx in patients with HCC. Evaluation based on CTC detection may enhance the post‐transplant management of HCC, and improve the therapeutic efficacy of LTx.
Patterns and mechanisms of spatial variation in tropical forest productivity, woody residence time, and biomass
Authors: Muller‐Landau Helene C. , Cushman K. C. , Arroyo Eva E. , Martinez Cano Isabel , Anderson‐Teixeira Kristina J. , Backiel Bogumila 
Published: November 2020

SummaryTropical forests vary widely in biomass carbon (C) stocks and fluxes even after controlling for forest age. A mechanistic understanding of this variation is critical to accurately predicting responses to global change. We review empirical studies of spatial variation in tropical forest biomass, productivity and woody residence time, focusing on mature forests. Woody productivity and biomass decrease from wet to dry forests and with elevation. Within lowland forests, productivity and biomass increase with temperature in wet forests, but decrease with temperature where water becomes limiting. Woody productivity increases with soil fertility, whereas residence time decreases, and biomass responses are variable, consistent with an overall unimodal relationship. Areas with higher disturbance rates and intensities have lower woody residence time and biomass. These environmental gradients all involve both direct effects of changing environments on forest C fluxes and shifts in functional composition – including changing abundances of lianas – that substantially mitigate or exacerbate direct effects. Biogeographic realms differ significantly and importantly in productivity and biomass, even after controlling for climate and biogeochemistry, further demonstrating the importance of plant species composition. Capturing these patterns in global vegetation models requires better mechanistic representation of water and nutrient limitation, plant compositional shifts and tree mortality.