bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Fishery after the Decline: The Susquehanna River Smallmouth Bass Story
Authors: Schall Megan K , Smith Geoffrey D , Blazer Vicki S , Walsh Heather L , Li Yan , Wagner Tyler 
Published: August 2020

Abstract
The Smallmouth Bass Micropterus dolomieu fishery in the Susquehanna River basin, Pennsylvania, is one of the most socioeconomically important fisheries in the region and has recently undergone considerable changes. These changes started in 2005, when disease was documented in young-of-the-year (age-0) Smallmouth Bass. Shortly thereafter, declines in abundance of both juveniles and adults were observed. These declines in abundance coincided with disease infections in age-0, intersex in adults, and concerns regarding contaminant exposure. Natural mortality rates, particularly for age-0, increased during this period (2005–2011), and there were concerns for the overall health of this world-class fishery. However, in recent years (2012–2017), there have been decreases in both mortality rates and external observations of disease and increases in abundance across multiple size-classes. Recent changes are encouraging for the future of the Smallmouth Bass fishery in the Susquehanna River. Yet, in light of the ever changing environmental, social, and anthropogenic influences on aquatic ecosystems, there remain concerns for Smallmouth Bass health and management. Because of this, ongoing research efforts are needed to monitor population and health changes and to conduct integrative research that considers complex relationships between organisms and their environments.
The roles of banana peel powders to alter technological functionality, sensory and nutritional quality of chicken sausage
Authors: Zaini Hana Binti Mohd , Sintang Mohd Dona Bin , Pindi Wolyna 
Published: August 2020

AbstractChicken sausages included with three different quantities of banana (Musa balbisiana) peel powder. The technological properties (cooking yield, texture, water‐holding capacity, color, rheology, and texture), composition, and sensory acceptability were assessed. In storage study, lipid oxidation of the best formulation from the sensory score was evaluated. The inclusion of banana peel powder (BPP) raises the nutritional value with regard to an increase in dietary fiber and a reduction in the sausage fat content. The addition of BPP also causes a significant increase in the cooking yield and water‐holding capacity. Additionally, storage modulus values increase with the increase in the BPP's concentration. However, with BPP incorporation, a hard texture and darkening of the sausage were observed. Interestingly, our findings exhibit the compromise in microstructural of chicken sausage with high percentage of BPP manifested by the high storage modulus and hardness but with low resistance toward stress, short linear viscoelastic region. This aspect also caused a significant change in the sensory score. The TBA value in the sausage containing 2% BPP exhibited a delay in lipid oxidation up to 55%, prompting its antioxidant potential. Generally, the incorporation of BPP to chicken sausage changes its properties. BPP has been a potential candidate as a value‐adding ingredient that may be used during meat preparation since it positively influences the nutritional value and specific technological properties of the food.
Efficient gene–environment interaction tests for large biobank‐scale sequencing studies
Authors: Wang Xinyu , Lim Elise , Liu Ching‐Ti , Sung Yun Ju , Rao Dabeeru C. , Morrison Alanna C. , Boerwinkle Eric , Manning Alisa K. , Chen Han 
Published: August 2020

AbstractComplex human diseases are affected by genetic and environmental risk factors and their interactions. Gene–environment interaction (GEI) tests for aggregate genetic variant sets have been developed in recent years. However, existing statistical methods become rate limiting for large biobank‐scale sequencing studies with correlated samples. We propose efficient Mixed‐model Association tests for GEne–Environment interactions (MAGEE), for testing GEI between an aggregate variant set and environmental exposures on quantitative and binary traits in large‐scale sequencing studies with related individuals. Joint tests for the aggregate genetic main effects and GEI effects are also developed. A null generalized linear mixed model adjusting for covariates but without any genetic effects is fit only once in a whole genome GEI analysis, thereby vastly reducing the overall computational burden. Score tests for variant sets are performed as a combination of genetic burden and variance component tests by accounting for the genetic main effects using matrix projections. The computational complexity is dramatically reduced in a whole genome GEI analysis, which makes MAGEE scalable to hundreds of thousands of individuals. We applied MAGEE to the exome sequencing data of 41,144 related individuals from the UK Biobank, and the analysis of 18,970 protein coding genes finished within 10.4 CPU hours.
Detecting X‐linked common and rare variant effects in family‐based sequencing studies
Authors: Turkmen Asuman S. , Lin Shili 
Published: August 2020

AbstractThe breakthroughs in next generation sequencing have allowed us to access data consisting of both common and rare variants, and in particular to investigate the impact of rare genetic variation on complex diseases. Although rare genetic variants are thought to be important components in explaining genetic mechanisms of many diseases, discovering these variants remains challenging, and most studies are restricted to population‐based designs. Further, despite the shift in the field of genome‐wide association studies (GWAS) towards studying rare variants due to the “missing heritability” phenomenon, little is known about rare X‐linked variants associated with complex diseases. For instance, there is evidence that X‐linked genes are highly involved in brain development and cognition when compared with autosomal genes; however, like most GWAS for other complex traits, previous GWAS for mental diseases have provided poor resources to deal with identification of rare variant associations on X‐chromosome. In this paper, we address the two issues described above by proposing a method that can be used to test X‐linked variants using sequencing data on families. Our method is much more general than existing methods, as it can be applied to detect both common and rare variants, and is applicable to autosomes as well. Our simulation study shows that the method is efficient, and exhibits good operational characteristics. An application to the University of Miami Study on Genetics of Autism and Related Disorders also yielded encouraging results.
Autofluorescence imaging to identify oral malignant or premalignant lesions: Systematic review and meta‐analysis
Authors: Kim Do Hyun , Kim Sung Won , Hwang Se Hwan 
Published: August 2020

AbstractThe aim is to evaluate the accuracy of autofluorescence for screening oral cancer in comparison with toluidine blue staining and clinical examination. Oral mucosal disorders detected by autofluorescence were compared with those detected using toluidine blue staining. Methodological quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies tool. The diagnostic odds ratio (DOR) for autofluorescence was 8.197 (95% confidence interval, 4.018‐16.723). The area under the summary receiver operating characteristic curve (AUC) was 0.815. Compared with toluidine blue, autofluorescence had a similar sensitivity, negative predictive value, and AUC but a lower specificity and DOR. Compared with clinical examination, the autofluorescence had a higher sensitivity but lower specificity, DOR, and AUC. Although the diagnostic accuracy of autofluorescence in the screening work‐up of oral cancer and precancer was more sensitive than those of clinical examination and toluidine blue staining, it was not accurate enough to be used alone reliably.
Prognostic nomogram for adenoid cystic carcinoma in different anatomic sites
Authors: Mu Xiaoli , Li Yan , He Ling , Guan Hui , Wang Jingjing , Wei Zhigong , He Yan , Liu Zheran , Li Ruidan , Peng Xingchen 
Published: August 2020

AbstractBackgroundAdenoid cystic carcinoma (ACC) is a relatively uncommon tumor. The existing prediction model is limited to the head and neck. We aim to construct a prognostic nomogram combined with the clinical features and treatment options of ACC to predict the disease‐specific survival (DSS) of patients diagnosed with ACC in different anatomic sites.MethodsA novel predictive model was constructed using 1285 patients with ACC from the Surveillance, Epidemiology, and End Results (SEER) registry between 2010 and 2015. The performance of this model was externally validated using 118 patients with ACC in the West China Hospital, Sichuan University between 2010 and 2017.ResultsThe prognostic model demonstrated that age, primary site, lymph node metastasis, distant metastasis, radiotherapy and surgery were independent factors for DSS. The validation of the model using an external cohort proved its reliability.ConclusionThe developed novel predictive model is shown to provide accurate and efficient predictive information for patients with ACC for different anatomic sites.
Defect Dynamics in MAPbI3 Polycrystalline Films: The Trapping Effect of Grain Boundaries
Authors: Mattoni Alessandro , Meloni Simone 
Published: August 2020

AbstractMetal halide perovskites, chemical compounds of ABX3 stoichiometry (A=CH3NH3+, Cs+, …; B=Pb2+, Sn2+; X=I−, Br−), have attracted great interest as they emerged as one of the most promising class of materials for low‐cost photovoltaics with over 25 % certified power conversion efficiency. An important open question for further improving their efficiency and stability is the formation and dynamics of point defects, for example, iodide vacancies and interstitials. In particular, recently it has been shown that defects strongly interact with grain boundaries, which, for example, prevents a quick restoration of initial conditions of film when kept in the dark after illumination [Phung et al., Adv. Energy Mater. 2020, 1903735]. It has also been shown that iodide defects may accumulate at grain boundaries, where they induce carriers’ recombination [Park et al., ACS Energy Lett. 2019, 4, 1321–1327]. In this article, we make use of molecular dynamics and ab initio simulations to follow the evolution and compute the energetics of a iodide vacancy,
, and an iodide Interstitial,
, interacting with Σ5/(102) grain boundaries of different termination, MAI and PbI2. We show that the polarization charge of Σ5/(102) grain boundary associated to a prescribed termination drives the dynamics of charged defects,
and
. The long‐range interaction of grain boundaries with charged species might induce the accumulation of point defects present in crystallites or formed under operation conditions. Moreover, the selective attraction of specific defects by a grain boundary may help splitting Frenkel pairs formed in solar cells under illumination, thus preventing the quick annihilation of defects and enhancing the effect of light in inducing degradation processes.
Detection of living cervical cancer cells by transient terahertz spectroscopy
Authors: Shi Wei , Wang Yuezheng , Hou Lei , Ma Cheng , Yang Lei , Dong Chengang , Wang Zhiquan , Wang Haiqing , Guo Juan , Xu Shenglong , Li Jing 
Published: August 2020

AbstractThe photonic energy of terahertz wave is in the same order of magnitude as the rotational and vibrational energy levels of organic and biological macromolecules, so it has unique advantages in detecting cells and biological macromolecules. However, in the life environment, the dynamic time scale of cell‐environment interaction and structural conformation change of biological macromolecules are within picosecond to millisecond, and water has strong absorption to terahertz wave, which has become the bottleneck problem for the detection of cells and biological macromolecules by terahertz technology. In this article, we developed a set of terahertz single measurement system based on the tilt wave front of grating pulse technique. The system was employed for the terahertz detection of trace living cervical cancer cells. We achieved transient detection of the terahertz pulse time‐domain waveform of the living HeLa cells. The characteristic absorption peaks were identified by Lambert‐Beer law, respectively, at 0.49, 0.71, 1.04, 1.07, 1.26 and 1.37 THz. The absorbance is proportional to the cell concentration.
Surface modification strategies for hemodialysis catheters to prevent catheter‐related infections: A review
Authors: Balikci Elif , Yilmaz Bengi , Tahmasebifar Aydin , Baran Erkan Türker , Kara Ekrem 
Published: August 2020

AbstractInsertion of a central venous catheter is one of the most common invasive procedures applied in hemodialysis therapy for end‐stage renal disease. The most important complication of a central venous catheter is catheter‐related infections that increase hospitalization and duration of intensive care unit stay, cost of treatment, mortality, and morbidity rates. Pathogenic microorganisms, such as, bacteria and fungi, enter the body from the catheter insertion site and the surface of the catheter can become colonized. The exopolysaccharide‐based biofilms from bacterial colonies on the surface are the main challenge in the treatment of infections. Catheter lock solutions and systemic antibiotic treatment, which are commonly used in the treatment of hemodialysis catheter‐related infections, are insufficient to prevent and terminate the infections and eventually the catheter needs to be replaced. The inadequacy of these approaches in termination and prevention of infection revealed the necessity of coating of hemodialysis catheters with bactericidal and/or antiadhesive agents. Silver compounds and nanoparticles, anticoagulants (e.g., heparin), antibiotics (e.g., gentamicin and chlorhexidine) are some of the agents used for this purpose. The effectiveness of few commercial hemodialysis catheters that were coated with antibacterial agents has been tested in clinical trials against catheter‐related infections of pathogenic bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis with promising results. Novel biomedical materials and engineering techniques, such as, surface micro/nano patterning and the conjugation of antimicrobial peptides, enzymes, metallic cations, and hydrophilic polymers (e.g., poly [ethylene glycol]) on the surface, has been suggested recently.
Fe/Mn multilayer nanowires as dual mode T1–T2 magnetic resonance imaging contrast agents
Authors: Gu Liyuan , Cao Xiaoming , Mukhtar Aiman , Wu KaiMing 
Published: August 2020

AbstractTo overcome the negative contrast limitations, and to improve the sensitivity of the magnetic resonance signals, the mesoporous silica coated Fe/Mn multilayered nanowires (NWs) were used as a T1–T2 dual‐mode contrast agents (CAs). The single component Fe and Mn NWs, and Fe/Mn multilayer NWs were synthesized by electrodeposition in the homemade anodic aluminum oxide (AAO) templates with the aperture of about 30 nm. The structural characterization and morphology of single component and multisegmented NWs was done by X‐ray diffraction and transmission electron microscopy. The elemental composition of Fe/Mn multilayerd NWs was confirmed by energy‐dispersive X‐ray and energy‐dispersive spectrometer. Vibrating sample magnetometer was used to test the magnetic properties, and 1.5 T magnetic resonance imaging (MRI) scanner was used to measure the relaxation efficiency. Importantly, the MRI study indicated that the Fe/Mn multilayer NWs showed a significant T1–T2 imaging effect, and have longitudinal relaxivity (r1) value, that is, 1.25 ± 0.0329 × 10−4 μM−1 s−1 and transverse relaxivity (r2), that is, 5.13 ± 0.123 × 10−4 μM−1 s−1, which was two times of r1 value (0.654 ± 0.00899 × 10−4 μM−1 s−1) of Mn NWs, and r2 value (2.96 ± 0.0415 × 10−4 μM−1 s−1) of Fe NWs. Hence, Fe/Mn multilayer NWs have potential to be used as T1–T2 dual‐mode CAs.
Evaluation of osteogenic and antibacterial properties of strontium/silver‐containing porous TiO2 coatings prepared by micro‐arc oxidation
Authors: Zhang Yang‐Yang , Zhu Ye , Lu Da‐Zhuang , Dong Wei , Bi Wen‐Juan , Feng Xiao‐Jie , Wen Li‐Ming , Sun Hong , Qi Meng‐Chun 
Published: August 2020

AbstractTi and Ti alloys are bioinert materials and two frequent problems associated with them are bacterial infection and lack of osteogenic potential for rapid bone integration. To overcome the problems, the present study incorporated strontium (Sr) and silver (Ag) simultaneously into porous TiO2 coatings through a single‐step technique, micro‐arc oxidation (MAO). Incorporation of Sr and Ag brought no significant changes to coating micromorphology and physicochemical properties, but endowed TiO2 coatings with both strong antibacterial activity and osteogenic ability. Antibacterial activity increased with Ag contents in the coatings. When Ag content reached 0.58 wt%, the coating showed both excellent short‐term (100.0%) and long‐term (77.6%) antibacterial activities. Sr/Ag‐containing coatings with 18.23 wt% Sr and 0.58 wt% Ag also presented good cytocompatibility for preosteoblast adhesion and proliferation, and promoted preosteoblast osteogenic differentiation both short‐termly and long‐termly. However, higher Ag content (1.29 wt%) showed toxic effects to preosteoblasts. In summary, MAO is a simple and effective way to incorporate Sr and Ag into porous TiO2 coatings and Sr/Ag‐containing TiO2 coating with 18.5 wt% Sr and 0.58 wt% Ag has both good osteogenic activity and strong antibacterial capability short‐termly and long‐termly. Therefore, such coatings are valuable for clinical application to strengthen osseointegration and long‐term high quality use of titanum implants.
Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines
Authors: Sritharan Sruthi , Sivalingam Nageswaran 
Published: August 2020

AbstractCurcumin has anti‐oxidant, anti‐cancer and anti‐carcinogen property. Our laboratory had previously reported that, curcumin treatment induces reactive oxygen species (ROS) generation in HT‐29 cell line, an effect contradictory to its anti‐oxidant property. This study evaluates the role of p53 in curcumin mediated ROS generation and cell death. Curcumin induced ROS was determined by 2’,7’‐dichlorofluorescein and apoptosis by Hoechst33342/PI staining in HT‐29 and HCT‐116 cell lines. ROS generation occurs within 1 hour of 40 µM curcumin treatment and a reduction was observed by third hour in HCT‐116 insinuating p53 involvement. N‐acetyl cysteine (NAC) pre‐treatment effectively quenched ROS and inhibited membrane potential loss in HT‐29, but less effective in HCT‐116. Mitochondrial membrane potential loss is evident with 10 and 40 µM curcumin in HCT‐116 and at 40 µM curcumin in HT‐29. Total p53 protein level increase was observed by 24 hours in HCT‐116 upon NAC pre‐treatment. Our results indicate that curcumin induces ROS mediated cell death in colon adenocarcinoma cell lines and may be mediated via p53.
Protective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters
Authors: Sacan Ozlem , Turkyilmaz Ismet Burcu , Bayrak Bertan Boran , Mutlu Ozgur , Akev Nuriye , Yanardag Refiye 
Published: August 2020

AbstractDiabetes mellitus is a serious worldwide metabolic disease, which is accompanied by hyperglycaemia and affects all organs and body system. Zinc (Zn) is a basic cofactor for many enzymes, which also plays an important role in stabilising the structure of insulin. Liver is the most important target organ after pancreas in diabetic complications. In this study, we aimed to investigate the protective role of Zn in liver damage in streptozotocin (STZ)‐induced diabetes mellitus. There are four experimental groups of female Swiss albino rats: group I: control; group II: control + ZnSO4; group III: STZ‐induced diabetic animals and group IV: STZ‐diabetic + ZnSO4. To induce diabetes, STZ was injected intraperitoneally (65 mg/kg). ZnSO4 (100 mg/kg) was given daily to groups II and IV by gavage for 60 days. At the end of the experiment, rats were killed under anaesthesia and liver tissues were collected. In the diabetic group, hexose, hexosamine, fucose, sialic acid levels, arginase, adenosine deaminase, tissue factor activities and protein carbonyl levels increased, whereas catalase, superoxide dismutase, glutathione‐S‐transferase, glutathione peroxidase, glutathione reductase and Na+/K+‐ATPase activities decreased. The administration of Zn to the diabetic group reversed all the negative effects/activities. According to these results, we can suggest that Zn has a protective role against STZ‐induced diabetic liver damage.
A longitudinal investigation of racial discrimination, distress intolerance, and psychological well‐being in African American college students
Authors: Le Thomas P. , Iwamoto Derek K. , Burke Lindsey A. 
Published: August 2020

AbstractThere is robust evidence that racism negatively influences health outcomes for African American college students. However, few studies have longitudinally examined the underlying mechanisms related to the repercussions of racism.ObjectiveThe purpose of this study was to examine the longitudinal association between racial discrimination and psychological well‐being (PWB), as well as the mediating role of distress intolerance.MethodAs part of a larger parent study, a sample of 105 African American first‐year undergraduate students (mean age = 18.1) completed three surveys across 1 year. The RMediation program was used to test the indirect effect of racism on PWB through distress intolerance.ResultsThere was a significant positive indirect effect of racism on PWB through distress intolerance, such that increased racism was associated with increased distress intolerance, which was thus associated with decreased PWB.ConclusionsIntervention efforts may be aimed at preventing racism for African American college students and providing clinical services that reduce distress intolerance.
Comprehensive study and multipurpose role of the CLV3/ESR‐related (CLE) genes family in plant growth and development
Authors: Khan Shahid U. , Khan Muhammad Hafeez U. , Ahmar Sunny , Fan Chuchuan 
Published: August 2020

AbstractThe CLAVATA3/endosperm surrounding region‐related (CLE) is one of the most important signaling peptides families in plants. These peptides signaling are common in the cell to cell communication and control various physiological and developmental processes, that is cell differentiation and proliferation, self‐incompatibility, and the defense response. The CLE signaling systems are conserved across the plant kingdom but have a diverse mode of action in various developmental processes in different species. In this review, we concise various methods of peptides identification, structure, and molecular identity of the CLE family, the developmental role of CLE genes/peptides in plants, environmental stimuli, and CLE family and some other novel progress in CLE genes/peptides in various crops, and so forth. According to previous literature, about 1,628 CLE genes were identified in land plants, which deeply explained the tale of plant development. Nevertheless, some important queries need to be addressed to get clear insights into the CLE gene family in other organisms and their role in various physiological and developmental processes. Furthermore, we summarized the power of the CLE family around the environment as well as bifunctional activity and the crystal structure recognition mechanism of CLE peptides by their receptors and CLE clusters functions. We strongly believed that the discovery of the CLE family in other organisms would provide a significant breakthrough for future revolutionary and functional studies.