bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing a link among total quality management, market orientation and organizational performance
Authors: Bhaskar Hari Lal 
Published: March 2020

PurposeThis paper presents findings of a survey on total quality management (TQM) practices adopted by the Indian manufacturing organizations. The purpose of this paper is to test and establish the relationship between TQM practice and organizational performance (OP). This paper also aims to examine the impact of TQM practices on OP of Indian manufacturing organizations.Design/methodology/approachA survey questionnaire was developed and randomly distributed through e-mail to senior managers of 275 Indian manufacturing organizations. About 230 received questionnaires were used for data analysis. Response rate was 83.63 percent. In particular, hypotheses were developed to examine the effect of TQM on the OP of the manufacturing organizations. Cronbach's alpha reliability of questionnaire was analyzed using factor analysis. Rigorous literature review is enabled to construct structural measurement model, formulation of testable hypothesis and operationalization of constructs.FindingsIt is discovered that TQM has a positive and significant effect on the market orientation (MO). Similarly, the results showed that MO has a positive and significant effect on the OP. With regard to the relationship between TQM and OP, this study found that TQM significantly and positively affects the OP of Indian manufacturing organizations.Originality/valueThis study is a rare and unique empirical study that establishes a link among TQM, MO and OP. The study fulfills need of quality management practice and offers practical implications to Indian managers and motivates further research on the relationship between TQM and OP in Indian manufacturing organizations.
Employees’ resistance to users’ ideas in public service innovation
Authors: Jenhaug Line Margrethe 
Published: March 2020

AbstractThis article contributes to the existing criticism of the positive emphasis on user participation in service innovation as co‐creation by examining employee resistance to user‐driven innovation. The empirical base comprises interviews, document studies, and observations from a project that focused on implementing a user‐initiated idea in public care services in Norway. To discuss employee resistance to innovative user ideas, a power perspective is included by drawing on the Foucault‐based theory of identity regulation and discourse. Employees resist the required identity regulation by distorting the initial innovative idea to align with their problem representations, which is facilitated by entangled discourses. The power relations embedded in the different parties’ subject positions emphasize how governing the user side is incompatible with being governed by the users. The article contributes to our knowledge of service innovation and the co‐creation of value by demonstrating discursive mechanisms for twisting value propositions.
Brexit and the British Constitution: Reflections on the Last Three years and the Next Fifty
Authors: Sumption Jonathan 
Published: March 2020

AbstractThe decision to leave the EU provoked the biggest constitutional crisis of recent British history. The referendum—a device for circumventing the parliamentary process—was followed by conflict between a minority government and a majority of MPs unwilling to leave the EU without satisfactory alternative arrangements. The courts, drawn into this conflict, upheld conventions that sustain the authority of Parliament and restrain the despotic power of ministers. The reaction of members of the current government was to take disreputable and anti‐democratic positions against both the Speaker of the House of Commons and the courts. They now have a sufficient majority in Parliament to resume adherence to constitutional conventions and restore a political culture of debate and tolerance, but they show little sign of doing so, and there is a risk that they will do irreparable damage to the political culture that underpins democracy.
What parties want from their leaders: How office achievement trumps electoral performance as a driver of party leader survival
Authors: ENNSER‐JEDENASTIK LAURENZ , SCHUMACHER GIJS 
Published: March 2020

AbstractRational choice theories of political behaviour start from the premise that parties seek policy, office, and votes. In accordance with this premise, previous research has shown that electoral performance and office achievement independently affect party leader survival. However, we know little about how goal attainment interacts across these two domains. This paper proposes a novel hypothesis stating that intrinsic goals (office) dominate over purely instrumental ones (votes). As a result, the impact of electoral performance on party leader survival should be conditional on office achievement. Using data on over 500 party leaders in 14 parliamentary democracies between 1965 and 2012, we show that electoral performance and office achievement strongly affect leadership turnover. However, we also demonstrate that the electoral performance effect disappears when parties enter or exit office at the same time. These results constitute the best direct evidence to date that parties prioritise office achievement over electoral success.
A systematic review of prevention and treatment of infantile colic
Authors: Hjern Anders , Lindblom Kristin , Reuter Antonia , Silfverdal Sven‐Arne 
Published: March 2020

AbstractAimThe aim of this review was to evaluate the evidence for interventions for infantile colic.MethodsThis was a systematic review based on a literature search in December 2017 for articles published during 2007–2017 about preventive and treatment interventions for infantile colic in infants. The review included original randomised controlled trials (RCTs) and meta‐analyses with at least 20 infants in each study group that were assessed according to GRADE criteria.ResultsThe review found moderately strong evidence that administration of Lactobacillus reuteri DSM 17938 shortened the crying duration, with positive evidence from three out of four national contexts. There were four RCTs of acupuncture, all with no or minimal effect on crying duration. All studies reviewed with a follow‐up until or beyond three months of age show a quite steep decline over time in crying duration in both treatment and control groups.ConclusionLactobacillus reuteri DSM 17938 is a promising treatment for infantile colic with moderately strong evidence in this review, but studies in more populations are needed. Acupuncture is not an effective treatment for infantile colic. Systematic support strategies to parents with infantile colic are important knowledge gaps.
How we manage Philadelphia‐negative myeloproliferative neoplasms in pregnancy
Authors: Robinson Susan E. , Harrison Claire N. 
Published: March 2020

SummaryThe combined incidence of classical Philadelphia‐negative myeloproliferative neoplasm (MPN) is 6–9/100 000 with a peak frequency between 50 and 70 years. MPN is less frequent in women of reproductive age. However, for essential thrombocythaemia (ET) in particular there is a second peak in women of reproductive age and 15% of polycythaemia vera (PV) patients are less than 40 years of age at the time of diagnosis. Thus these diseases are encountered in women of reproductive potential and may be diagnosed in pregnancy or in women being investigated for recurrent pregnancy loss. The incidence of MPN pregnancies is 3·2/100 000 maternities per year in the UK. The majority of data regarding Philadelphia‐negative MPNs relates to patients with ET, for which the literature suggests significant maternal morbidity and poor fetal outcome; specifically maternal thrombosis and haemorrhage, miscarriage, pre‐eclampsia, intrauterine growth restriction (IUGR), stillbirth and premature delivery as summarised in the recent systematic review and meta‐analysis in Blood, 2018, 132, 3046. The literature for PV is more sparse but increasing and is concordant with ET pregnancy outcomes. The literature regarding primary myelofibrosis (PMF) is even more scarce. Treatment options include aspirin, venesection, low molecular weight heparin (LMWH) and cytoreductive therapy. Data and management recommendations are often extrapolated from other pro‐thrombotic conditions or from ET to PV and PMF. Women of reproductive age with a diagnosis of MPN should receive information and assurance regarding management and outcome of future pregnancies. From pre‐conceptual planning to the post‐partum period, women should have access to joint care from an obstetrician with experience of high‐risk pregnancies and a haematologist in a multidisciplinary setting. This paper provides an update with regards to Philadelphia‐negative MPN in pregnancy, details local practise in an internationally recognised centre for patients with MPN and outlines a future research strategy.
Vitamin D status and the immune assessment in 22q11.2 deletion syndrome
Authors: Legitimo A , Bertini V , Costagliola G , Baroncelli G I , Morganti R , Valetto A , Consolini R 
Published: March 2020

Summary
22q11.2 deletion syndrome (22q11.2DS) is characterized by a heterogeneous phenotype, including alterations in phospho-calcium metabolism and immunodeficiency. We analyzed vitamin D status and the immune assessment, focusing on T cell subpopulations and dendritic cells (DCs) in a cohort of 17 pediatric 22q11.2DS patients and 17 age-matched healthy subjects. As antigen-presenting cells, DCs are the main target of vitamin D, promoting a tolerogenic T cell response. Patients were subdivided into three groups according to the parameters of phospho-calcium metabolism and serum levels of 25OHD: normal values, vitamin D deficiency and hypoparathyroidism. Different degrees of T cell deficiency, ranging from normal to partial T cell numbers, were observed in the cohort of patients. The group with vitamin D deficiency showed a significant reduction of naive T cells and a significant increase of central memory T cells compared to controls. In this group the number of circulating DCs was significantly reduced. DC decrease affected both myeloid and plasmacytoid DC subsets (mDCs and pDCs), with the most relevant reduction involving pDCs. A direct correlation between 25OHD levels and recent thymic emigrant (RTE) and DC number was identified. Despite the limited cohort analyzed, our results show that deficiency of the pDC subset in patients with 22q11.2DS may be included among the causative factors of the progressive increase of risk of autoimmune diseases in these patients. As most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, we suggest a potential role of vitamin D supplementation in preventing autoimmune or proinflammatory diseases in 22q11.2DS.
Cone beam computed tomography artefacts around dental implants with different materials influencing the detection of peri‐implant bone defects
Authors: Schriber Martina , Yeung Andy Wai Kan , Suter Valerie G.A. , Buser Daniel , Leung Yiu Yan , Bornstein Michael M. 
Published: March 2020

AbstractObjectivesTo investigate the diagnostic accuracy of cone beam computed tomography (CBCT) for the diagnosis of peri‐implant bone defects of titanium (Ti), zirconium dioxide (ZrO2) or titanium–zirconium (Ti–Zr) alloy implants.Materials and MethodsTi, Ti–Zr or ZrO2 implants with two diameters (3.3 mm, 4.1 mm) and one length (10 mm) were inserted in the angle of the mandible of six fresh defrosted pig jaws. Out of the 12 implants inserted, 6 served in the test group with standardized buccal peri‐implant bone defects, whereas 6 served as control without bone defects. CBCTs were performed with three acquisition protocols (standard, high and low dose) using two devices. Four observers analysed CBCTs as follows: (a) presence of a peri‐implant defect; (b) presence of peri‐implant artefacts and impact on defect diagnosis; and (c) linear measurements of buccal peri‐implant defect including height and width (in mm).ResultsCBCT device, CBCT settings, implant material, implant diameter and observer background did not significantly influence diagnostic accuracy. The sensitivity and specificity values were high for defect detection. ZrO2 led to a lower than average diagnostic accuracy (0.781). The linear measurements of peri‐implant defect were underestimated by <1 mm on average. The subjective impact of artefacts on defect diagnosis was significantly affected by implant material and observer background.ConclusionsCBCT showed high diagnostic accuracy for peri‐implant bone defect detection regardless of the device, imaging setting or implant material used. If CBCT is indicated to assess peri‐implant bone disease, low dose protocols could be a promising imaging modality.
Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam: The HELIUS study
Authors: Alberts Catharina J. , Jeske Rima , de Martel Catherine , den Hollander Wouter J. , Michel Angelika , Prins Maria , Snijder Marieke B. , Schim van der Loeff Maarten F. , Waterboer Tim 
Published: March 2020

AbstractBackgroundHelicobacter pylori prevalence varies greatly worldwide. We explored the prevalence of H. pylori and CagA seropositivity among adults aged 18‐44 years living in the Netherlands by ethnicity and migration status (first vs second generation).Materials and MethodsParticipants from six different ethnic groups were selected from the population‐based multi‐ethnic HELIUS study in Amsterdam, the Netherlands. Serum samples were tested for H. pylori antigens using a validated Luminex‐based multiplex serology assay. Prevalence ratios were estimated using Poisson regression analysis.ResultsA total of 4683 participants aged 18‐44 years were randomly selected based on sex, ethnicity, and age. H. pylori seroprevalence was highest in the Ghanaian group (84%), followed by Moroccan (81%), Turkish (66%), African Surinamese (51%), South‐Asian Surinamese (48%), and Dutch (17%) participants. All ethnic minority groups had a significantly higher risk of being H. pylori seropositive compared to the Dutch group. This association was strongest among participants born outside the Netherlands (first generation), but was still significant and apparent among second‐generation participants. Among first‐generation participants, all groups, except the Moroccans, had a significantly higher proportion of individuals with a cagA + H. pylori strain compared to the Dutch participants.ConclusionHelicobacter pylori seroprevalence among first‐generation migrants is high in the Netherlands and remains elevated among second‐generation migrants (ie, those born in the Netherlands). High exposure to H. pylori, and especially to the more virulent cagA+ strain, highlights the need for tailored prevention of gastric diseases (notably peptic ulcers and cancers) among migrants.
TERT and TERC mutations detected in cryptic dyskeratosis congenita suppress telomerase activity
Authors: Terada Kazuki , Miyake Koichi , Yamaguchi Hiroki , Miyake Noriko , Yamanaka Keiichiro , Kojima Seiji , Ito Etsuro , Inokuchi Koiti , Okada Takashi 
Published: March 2020

AbstractIntroductionA cryptic form of dyskeratosis congenita (cDKC) has a gradual onset without the characteristic physical findings of DKC. cDKC is distinguished from other forms of bone marrow failure (BMF) through analysis of telomere shortening and gene mutations. Mutations in the telomerase reverse transcriptase (TERT) and telomere RNA component (TERC) genes have been detected in most Japanese cDKC patients. Therefore, we investigated the impact of each TERT and TERC mutation on telomerase activity.MethodsTERT and TERC mutants observed in DKC or cDKC patients were transfected into Saos‐2 or VA13+TERT (TERT‐expressing VA13 cells) cells to measure telomerase activity.ResultsTelomerase activity in cells expressing a mutant detected in cDKC patients was significantly lower (P < .0001) than in cells expressing the wild‐type genes. In addition, some TERT mutations seen in cDKC (p.P632R, p.T726M) caused weaker (P = .0013) suppression of telomerase activity than others (p.G106W and p.G682D). In contrast, telomerase activity in cells expressing a TERT or TERC mutant detected in DKC patients did not significantly differ from cells expressing the wild‐type genes.ConclusionThese findings suggest that TERT and TERC mutations detected in cDKC patients could potentially contribute to the pathogenesis of cDKC by blocking telomerase activity. However, TERT and TERC mutations detected in DKC patients did not affect telomerase activities, which means studying the telomerase activity of mutants are not always useful for the diagnosis of DKC.
CW laser‐initiated formation of nano‐Si crystals in glass‐metal nanostructures
Authors: Babich Ekaterina S. , Redkov Alexey V. , Melehin Vladimir G. , Khlopin Dmitry , Béal Jérémie , Laux Frédéric , Gérard Davy , Lipovskii Andrey A. 
Published: March 2020

AbstractLocal and controllable growth of nanocrystalline silicon (nano‐Si) in a commercial borosilicate glass is demonstrated. The nano‐Si was formed in the subsurface region of the glass via aluminothermic reaction in the course of the irradiation of a 2D array of aluminum nanodisks fabricated on the glass surface with CW low‐power 633 and 532 nm lasers. The thermoplasmonic nature of the nanodisks heating is demonstrated: at low incident intensity, the phenomenon takes place only if the plasmon resonance of the array and the laser wavelength is close enough. However, when the laser beam intensity at the sample surface exceeds 8 MW/cm2 mutual position of the plasmon resonance and the laser wavelength weakly influences the phenomenon. The nano‐Si formation is studied with Raman scattering technique, and the average size of the silicon nanocrystals is evaluated.
Effects of ipragliflozin on the development and progression of kidney disease in patients with type 2 diabetes: An analysis from a multicenter prospective intervention study
Authors: Matsuba Ikuro , Kawata Takehiro , Iemitsu Kotaro , Asakura Taro , Amemiya Hikaru , Ishikawa Masashi , Ito Syogo , Kaneshiro Mizuki , Kanamori Akira , Kubota Akira , Shinoda Kazuaki , Takai Masahiko , Takuma Tetsuo , Takihata Masahiro , Takeda Hiroshi , Tanaka Keiji , Matsuzawa Yoko , Machimura Hideo , Minagawa Fuyuki , Minami Nobuaki , Mokubo Atsuko , Miyakawa Masaaki , Terauchi Yasuo , Tanaka Yasushi 
Published: March 2020

AbstractAims/IntroductionType 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long‐term treatments are available. MethodsThis was an investigator‐initiated multicenter prospective intervention study in which ipragliflozin (50 mg) was administered once daily, and glycemic control, estimated glomerular filtration rate (eGFR) and adverse events were evaluated until 104 weeks after starting research.ResultsThere were 407 patients analyzed. In the eGFR ≥90 group and eGFR ≥60 to <90 group, eGFR had significantly decreased compared with baseline at all time points from 4 to 104 weeks. There were significant increases in the eGFR ≥45 to <60 groups compared with baseline at 36 weeks (2.3 ± 1.0) and 52 weeks (2.6 ± 1.2). Comparison between the eGFR <60, urine albumin‐to‐creatinine ratio >300 group and the eGFR <60, urine albumin‐to‐creatinine ratio <300 group showed a greater reduction in eGFR in the former (−5.4 ± 2.4 vs 3.3 ± 1.1) at 12 weeks and was maintained to 104 weeks. In any group, eGFR did not significantly decrease until 104 weeks compared with 4 weeks. The urine albumin‐to‐creatinine ratio after 52 weeks and after 104 weeks was significantly decreased compared with baseline in the eGFR ≥90 group.ConclusionsIpragliflozin lowers eGFR and corrects hyperfiltration in patients with high eGFR (eGFR ≥60). In patients with low eGFR (eGFR ≥30 to <60), ipragliflozin has the possibility of increasing eGFR and exerting a renoprotective effect.
Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases
Authors: Corti Olga , Blomgren Klas , Poletti Angelo , Beart Philip M. 
Published: March 2020

AbstractIn autophagy long‐lived proteins, protein aggregates or damaged organelles are engulfed by vesicles called autophagosomes prior to lysosomal degradation. Autophagy dysfunction is a hallmark of several neurodegenerative diseases in which misfolded proteins or dysfunctional mitochondria accumulate. Excessive autophagy can also exacerbate brain injury under certain conditions. In this review, we provide specific examples to illustrate the critical role played by autophagy in pathological conditions affecting the brain and discuss potential therapeutic implications. We show how a singular type of autophagy‐dependent cell death termed autosis has attracted attention as a promising target for improving outcomes in perinatal asphyxia and hypoxic‐ischaemic injury to the immature brain. We provide evidence that autophagy inhibition may be protective against radiotherapy‐induced damage to the young brain. We describe a specialized form of macroautophagy of therapeutic relevance for motoneuron and neuromuscular diseases, known as chaperone‐assisted selective autophagy, in which heat shock protein B8 is used to deliver aberrant proteins to autophagosomes. We summarize studies pinpointing mitophagy mediated by the serine/threonine kinase PINK1 and the ubiquitin–protein ligase Parkin as a mechanism potentially relevant to Parkinson's disease, despite debate over the physiological conditions in which it is activated in organisms. Finally, with the example of the autophagy‐inducing agent rilmenidine and its discrepant effects in cell culture and mouse models of motor neuron disorders, we illustrate the importance of considering aspects such a disease stage and aggressiveness, type of insult and load of damaged or toxic cellular components, when choosing the appropriate drug, timepoint and duration of treatment.
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Effect of Tooth Preparation Design on Fracture Resistance of Zirconia‐Reinforced Lithium Silicate Overlays
Authors: Falahchai Mehran , Babaee Hemmati Yasamin , Neshandar Asli Hamid , Rezaei Elnaz 
Published: March 2020

AbstractPurposeTo assess the effect of tooth preparation design on fracture resistance of zirconia‐reinforced lithium silicate overlays.Materials and MethodsThis study evaluated 50 human maxillary first molars with no caries, restorations or anatomical defects. The teeth were randomly divided into five groups (n = 10/group) based on preparation design for the fabrication of overlay restorations: (O) anatomical occlusal reduction, (OS) anatomical occlusal reduction with round shoulder preparation, (OG) anatomical occlusal reduction with a central groove, (OSG) anatomical occlusal reduction with round shoulder preparation and central groove, and (C) no preparation of tooth (control group). All restorations were fabricated using zirconia‐reinforced lithium silicate (Vita Suprinity). The specimens underwent thermomechanical fatigue loading in a masticatory simulator (1.2 million cycles at 98 N). Fracture resistance was measured using a universal testing machine. The mode of failure was determined as well. Data were analyzed using one‐way ANOVA followed by Tukey's post‐hoc test, paired t‐test and Fisher's exact test (α = 0.05).ResultsGroup O showed significantly higher fracture resistance than groups OG and OSG (p = 0.002 and p = 0.001, respectively). The fracture resistance of group OS was significantly higher than that of group OSG (p = 0.008). The fracture resistance of the control group was significantly higher than that of OG and OSG (p = 0.001) and had no significant difference with other groups.ConclusionsGroup O (anatomical occlusal reduction alone), which had the most conservative preparation design, yielded the highest fracture resistance.