bluuebunny/crossref_metadata_2025_split huggingface dataset:
The adsorption of Mn(II) by insolubilized humic acid
Authors: Zhao Wenlin , Ren Bozhi , Hursthouse Andrew , Jiang Feng 
Published: August 2020

Abstract
The eco-friendly and non-toxic natural organic substance, insolubilized humic acid (IHA), was used to remove Mn(II) from aqueous solutions. The adsorption characteristics were studied through a series of static adsorption tests. The results show that conditions such as the dose, the pH of the solution and the initial concentration of Mn(II) all affect removal efficiency, and the optimal pH value was 5.5. The sorption process for Mn(II) on IHA conforms to the pseudo-second-order adsorption kinetic model and intra-particle diffusion is not the only factor affecting the adsorption rate. Both Langmuir and Freundlich models can describe this adsorption behavior, and the experimental maximum adsorption capacity of IHA was 52.87 mg/g under optimal conditions. The thermodynamic analysis of adsorption shows that the adsorption process is a non-spontaneous endothermic physical reaction. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS) were used to characterize the samples, it was found that as IHA successfully adsorbed Mn(II), the surface morphology of IHA changed after the adsorption reaction. The adsorption mechanism for Mn(II) on IHA is to provide electron pairs for carboxyl, phenolic hydroxyl and other functional groups to form stable complexes with Mn(II).
Pentoxifylline and Oxypurinol: Potential Drugs to Prevent the “Cytokine Release (Storm) Syndrome” Caused by SARS-CoV-2?
Authors: López-Iranzo Francisco J. , López-Rodas Ana M. , Franco Luis , López-Rodas Gerardo 
Published: August 2020

Background:
COVID-19, caused by SARS-CoV-2, is a potentially lethal, rapidly-expanding pandemic
and many efforts are being carried out worldwide to understand and control the disease. COVID-19 patients may
display a cytokine release syndrome, which causes severe lung inflammation, leading, in many instances, to
death.

Objective:
This paper is intended to explore the possibilities of controlling the COVID-19-associated hyperinflammation
by using licensed drugs with anti-inflammatory effects.

Hypothesis:
We have previously described that pentoxifylline alone, or in combination with oxypurinol, reduces
the systemic inflammation caused by experimentally-induced pancreatitis in rats. Pentoxifylline is an inhibitor of
TNF-α production and oxypurinol inhibits xanthine oxidase. TNF-α, in turn, activates other inflammatory genes
such as Nos2, Icam or IL-6, which regulate migration and infiltration of neutrophils into the pulmonary interstitial
tissue, causing injury to the lung parenchyma. In acute pancreatitis, the anti-inflammatory action of pentoxifylline
seems to be mediated by the prevention of the rapid and presumably transient loss of PP2A activity. This may
also occur in the hyperinflammatory -cytokine releasing phase- of SARS-CoV-2 infection. Therefore, it may be
hypothesized that early treatment of COVID-19 patients with pentoxifylline, alone or in combination with oxypurinol,
would prevent the potentially lethal acute respiratory distress syndrome.

Conclusion:
Pentoxifylline and oxypurinol are licensed drugs used for diseases other than COVID-19 and, therefore,
phase I clinical trials would not be necessary for the administration to SARS-CoV-2- infected people. It
would be worth investigating their potential effects against the hyperinflammatory response to SARS-CoV-2
infection.
The Role of Bacterial Superantigens in the Immune Response: From Biology to Cancer Treatment
Authors: Hashemzadeh Mohammad S. , Tapeh Behnam E.G. , Mirhosseini Seyed A. 
Published: August 2020

Aims:Encouraging results have been indicated preclinically and in patients using the bacterial superantigen. This review article intends to summarize the role of the superantigens that have been recently used in the treatment of cancer. In addition, the vector systems, including lentiviral vectors, adeno-associated vector systems and retroviral vectors that are increasingly being used in basic and applied research, were discussed. Most importantly, the new CRISPR technique has also been discussed in this literature review.Discussion:More successful therapies can be achieved by manipulating bacterial vector systems through incorporating genes related to the superantigens and cytokines. The products of SAg and cytokine genes contribute to the strong stimulation of the immune system against tumor cells. They bind to MHC II molecules as well as the V beta regions of TCR and lead to the production of IL2 and other cytokines, the activation of antigen-presenting cells and T lymphocytes. Additionally, superantigens can be used to eradicate tumor cells. Better results in cancer treatment can be achieved by transferring superantigen genes and subsequent strong immune stimulation along with other cancer immunotherapy agents.Conclusion:Superantigens induce the proliferation of T lymphocytes and antigen-presenting cells by binding to MHCII molecules and V beta regions in T cell receptors. Therefore, the presentation of tumor cell antigens is increased. Additionally, the production of important cytokines by T cells and APCs contributes to the stimulation of immune response against tumor cells. The manipulation of bacterial vector systems through incorporating genesrelated to SAgs and other immune response factors is a good strategy for the immune system stimulating and eradicating tumor cells along with other immunotherapy agents.
Different Pharmacokinetic Responses to an Acute Dose of Inorganic Nitrate in Patients with Type 2 Diabetes
Authors: Bahadoran Zahra , Mirmiran Parvin , Carlström Mattias , Norouzirad Reza , Jeddi Sajad , Azizi Fereidoun , Ghasemi Asghar 
Published: August 2020

Aim:In this study, we aimed to compare the pharmacokinetics of nitrate (NO3) in patients with type 2 diabetes mellitus (T2DM) and healthy adults. Potential effects of salivary nitrate reductase (NR) activity on cardiometabolic responses to an acute dose of NO3was also assessed.Methods:Nine healthy adults and nine T2DM patients were recruited to consume a NO3-rich breakfast (~410 mg NO3). Pharmacokinetics of NO3were examined using repeated measurements of NOx (nitrate+ nitrite) concentrations of serum and saliva over 8 hours and NO3concentrations of spot and 24-h urine samples. Cardiometabolic parameters, including serum levels of glucose, insulin, and triglycerides as well as blood pressure were also measured.Results:Compared to patients with T2DM, serum NOx concentration (Δ1= 16.7 vs. 4.4 μmol/L, P=0.057) of healthy subjects sharply increased within 1 hour after NO3loading. Healthy subjects had a higher NR activity index, and higher peak salivary NO3concentration with a lower time to peak. Diabetic patients with high- compared to low-NR values had a higher whole-body NOx exposure (103±31.4 vs. 58.9±22.1 μmol.h/L); they also showed a better glycemic response and more reduction of blood pressure following ingestion of a NO3-rich meal.Conclusion:T2DM may be associated with a different pattern of NOx pharmacokinetics (especially salivary NOx metabolism). Salivary NR activity may have a critical role in postprandial metabolism of NO3, and diabetic patients with higher NR activity may take more advantages from NO3supplementation.
Recovery of Missing Sensor Data with GRNN-based Cascade Scheme
Authors: Tkachenko Roman , Izonin Ivan , Dronyuk Ivanna , Logoyda Mykola , Tkachenko Pavlo 
Published: August 2020

Background:
Today, IoT-based systems are widely used in various applications. Intellectual
analysis of the data collected by IoT devices is an important task for the efficient and successful
functioning of such systems. In particular, the reliability of such kind of analysis has greatly
influenced the ability to partially or fully automate certain processes or subsystems. However,
imperfect devices of data collection, transportation errors, etc. lead to gaps in the data. Such incompetency
makes an effective intellectual data analysis for the specific tasks impossible. That is
why there must be a scientific solution to this problem of effectively filling the gaps in the data
collected by the IoT sensors.

Methods:
The authors propose a new prediction method for solving this problem based on the use of General Regression
Neural Networks (GRNN).

Results:
The possibility of approximation and partial elimination of the error of this computational
intelligence tool has been analytically proved. A prediction method based on the use of GRNN
was developed. The optimal parameters of the developed method were selected. The simulation of
its work was performed to solve the problem of recovery of missing sensor data in the air pollution
monitoring dataset.

Conclusion:
The highest accuracy of the developed method in comparison with other methods of
this class was experimentally established. All advantages and disadvantages are described. Perspectives
of further research are outlined.
When Public Health Research Meets Social Media: Knowledge Mapping From 2000 to 2018
Authors: Zhang Yan , Cao Bolin , Wang Yifan , Peng Tai-Quan , Wang Xiaohua 
Published: August 2020

Background
Social media has substantially changed how people confront health issues. However, a comprehensive understanding of how social media has altered the foci and methods in public health research remains lacking.

Objective
This study aims to examine research themes, the role of social media, and research methods in social media–based public health research published from 2000 to 2018.

Methods
A dataset of 3419 valid studies was developed by searching a list of relevant keywords in the Web of Science and PubMed databases. In addition, this study employs an unsupervised text-mining technique and topic modeling to extract research themes of the published studies. Moreover, the role of social media and research methods adopted in those studies were analyzed.

Results
This study identifies 25 research themes, covering different diseases, various population groups, physical and mental health, and other significant issues. Social media assumes two major roles in public health research: produce substantial research interest for public health research and furnish a research context for public health research. Social media provides substantial research interest for public health research when used for health intervention, human-computer interaction, as a platform of social influence, and for disease surveillance, risk assessment, or prevention. Social media acts as a research context for public health research when it is mere reference, used as a platform to recruit participants, and as a platform for data collection. While both qualitative and quantitative methods are frequently used in this emerging area, cutting edge computational methods play a marginal role.

Conclusions
Social media enables scholars to study new phenomena and propose new research questions in public health research. Meanwhile, the methodological potential of social media in public health research needs to be further explored.
RELEVANSI PENDIDKAN PANCASILA DAN POTRET MAHASISWA DI PERGURUAN TINGGI
Authors: Eleanora Fransiska Novita , Sari Andang 
Published: August 2020

Penelitian ini bertujuan untuk mengetahui bahwa wujud nyata dari implementasi pendidikan pancasila dan nila-nilai dari setiap sila-sila didalamnya dapat disosialisasikan dengan mengikutsertakan dan melibatkan mahasiswa dalam keikutsertaan tri dharma perguruan tinggi dalam mengembangkan wawasan, pengetahuan bahkan juga keahlian yang sudah didapatkan atau diperoleh selama berada di bangku perkuliahan serta mempraktekkan keahliannya dalam kehidupan ataupun juga terjuan dan ikut serta dala masyarakat, yang sesuai dengan nila-nilai kehidupan dan juga kemanusiaan juga moral dan norma dalam pancasila. Relevansinya dalam mengimplemantasikan khususnya dalam bidan pennelitian dan juga pengabdian masyarakat, Dengan mendapatkan dan juga memperoleh ilmu di universitas maka mahasiswa tersebut dapat juga mengamalkan dan mengabdikan dalam di lingkungan tempat tinggalnya, sesuai dengan bidang keahliannya. Metode yang digunakan dalam penelitian ini adalah penelitian pustaka dengan mengkaji buku-buku dan literatur-literatur. Hasilnya adalah Pengamalan Pancasila yang didapatkan atau diterima mahasiswa di perguruan tinggi dapat diterapkan bukan hanya sebatas dilingkungan tempat, tinggalnya saja tetapi juga kepada implementasi Tri Dharma Perguruan Tinggi itu sendiri, dan hal ini akan berdampak luas kepada mahasiswa itu sendiri dalam lingkungan kerjanya nanti yang akan terlihat jika mahasiswa tersebut sudah lulus dan mendapatkan pekerjaannya, sesuai dengan bidang skili dan pengalamannya selama terjun dan mengabdikan dirinya dalam rangka mengimplementasikan Tri Dharma dari Perguruan Tinggi tersebut.
Pengaruh Model Pembelajaran Berbasis Masalah Terhadap Hasil Belajar Di SMAN 1 Pacet
Authors: Setiyowati Rini , Kurniawan Moh. Wahyu , Widodo Rohmad 
Published: August 2020

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran berbasis masalah terhadap hasil belajar PPKn, Penelitian ini merupakan penelitian eksperimen semu (quasi exsperiment) yang dilaksanakan di SMA Negeri 1 Pacet Kabupaten Mojokerto tahun pelajaran 2016/2017 kelas X semester satu. Desain penelitian berupa Pretest-posttest control group design. Subjek penelitian/responden terdiri dari 3 kelas dengan jumlah 33 orang kelas eksperimen 1, 34 orang kelas eksperimen 2, dan 31 kelas kontrol, hal ini didasarkan kelas tersebut memiliki tingkat kognitif yang sama, sehingga total populasi berjumlah 98 orang. Instrumen yang digunakan dalam penelitian ini adalah tes untuk mengetahui hasil belajar PPKn dan angket untuk mengetahui motivasi belajar siswa. Analisis data dalam penelitian ini menggunakan independent sample t-test dengan taraf signifikansi 5% atau 0,05. Hasil penelitian menunjukkan bahwa: (1) terdapat pengaruh model pembelajaran berbasis masalah terhadap motivasi belajar peserta didik dalam pembelajaran PPKn dengan hasil signifikasi sebesar 10,933 lebih besar dari 3,09; (2) terdapat pengaruh model pembelajaran berbasis masalah terhadap hasil belajar peserta didik dalam pembelajaran PPKn dengan hasil signifikasi sebesar 32,737 lebih besar dari 3,09; (3) terdapat pengaruh model pembelajaran berbasis masalah terhadap hasil belajar dan motivasi belajar peserta didik dalam pembelajaran PPKn dengan hasil signifikasi sebesar 0,000 lebih kecil dari 0,05 (p= 0,000 < 0,05); dan (4) terdapat model yang paling efektif dalam pembelajaran PPKn yaitu model pembelajaran berbasis masalah ditujukkan dengan hasil gain score motivasi belajar sebesar 0.35 dalam kategori sedang dan didukung hasil gain score pada hasil belajar siswa sebesar 0.37 dalam kategori sedang, sedangkan model pembelajaran inquiri dan model konvensional masuk dalam kategori rendah.
Keterlibatan Warga Negara Dalam Pembangunan Berkelanjutan Melalui Produksi Gula Aren
Authors: Wadu Ludovikus Bomans , Ladamay Iskandar , Bandut Stanislaus 
Published: August 2020

Penelitian ini mendeskripsikan keterlibatan warga Negara dalam pembangunan berkelanjutan melalui program produksi gula aren. Metode penelitian menggunakan pendekatan kualitatif dengan jenis studi kasus. Teknik pengumpulan data yang digunakan adalah Observasi, wawancara dan dokumentasi. Hasil dari penelitian menunjukan bahwa bentuk keterlibatan warga Negara dalam pembangunan berkelanjutan melalui produksi gula aren terbagi dalam dua tahap penting yang antara lain (1) penguatan dalam tahap persiapan yang meliputi pencarian kayu api, pengambilan nira, pembuatan gula aren dan pengemasan sedangkan (2) penguatan dalam tahap pengelolaan yang meliputi pemasaran gula aren dan juga dari segi kebutuhan, masyarakat memanfaatkan gula aren sebagai barang konsumsi setiap hari. Melalui kegiatan ini warga negara terlibat dalam mendukung tujuan pembangunan berkelanjutan. Pembangunan berkelanjutan yang dimaksudkan adalah pembangunan didalam bidang ekonomi dengan sasaran utamanya adalah terciptanya pertumbuhan ekonomi masyarakat dan tersedianya lapangan pekerjaan.
Isso será e Isso foi Destruído: As imagens de Bento Rodrigues no Google Street View
Authors: Vasco Marcela Roberta Guimarães 
Published: August 2020

Em 5 de novembro de 2015, a barragem de rejeitos de mineração de Fundão, pertencente à mineradora Samarco (Vale/BHP Billiton), se rompe sobre Bento Rodrigues, subdistrito da cidade de Mariana (MG), destruindo quase completamente o pequeno povoado. Anos antes, porém, imagens de Bento Rodrigues foram captadas pelo serviço do Google Street View. A representação virtual do passado de um ambiente assolado assombram. Neste ensaio, procuro explorar essas imagens de um povoado que, ao mesmo tempo, será e foi destruído.
Pancasila and Economy Prophetic: the Reconstruction Efforts of Indonesian Economic Law
Authors: Septyanun Nurjannah , Yuliani Tin 
Published: August 2020

Purphose: The importance of the transcendental paradigm, able to change the demoralization of the economic sphere, affects the changing economic goals of Pancasila. Methodology: Using normative legal research, with paradigmatic approaches and using qualitative descriptive analysis. Finding: The symbolic phenomenon of religious rituals is not merely ritualism in the concept of civil religion. But able to penetrate the particulate partition of the operational dimension. Similarly, the prophetic paradigm, with its prophetic ethics in terms of liberation, humanization, Transcendence, gives space to the fundamental beliefs of society in economics. Civil religion minimizes the ongoing dominance, hegemonic, and exploitative of anti-humanity. The prophetic paradigm and civil religion are capable of being great energy for the realization of the idealism of Pancasila, the first of the transcendental meaning. Importance: The transcendental dimension, of the first Sila, being a turning point. The importance of awareness of the community, and the legal traveler for the reconstruction of Indonesian economic law to realize the social justice of Pancasilais. Originality/Novelty: The Prophetic and civil religion paradigms, becoming one of the bids on economic demoralization. Keyword: Civil Religion; Profetic ethics; Pancasila; Indonesian economic law.
Study Von Savigny's Thinking About Morals in Law: Understanding Moral in the Concept of Law “Barenti Lako Syara’ Tradition, Syara Barenti Lako Kitabullah”
Authors: Dianto Dianto 
Published: August 2020

Objective: This article aims to discuss moral boundaries in the Law According to Von Savigny and moral limits in the Law According to the Legal Concept Principles of “Barenti Lako Syara’ Tradition, syara barenti ko kitabullah”Methodology: The methodology used in this study is normative juridical research. This study uses a philosophical approach by exploring the philosophical basis of Law by linking legal science with the concept of customary Law.Findings: Von Savigny does not limit the moral meaning in Law whether good or bad, wrong or right, depends on morals in the habits of society that are not separate from morals and facts. Meanwhile, tau samawa based on the legal concept of “barenti lako syara’ tradition, sara barenti lako Kitabullah” means moral boundaries in Law, morals can be accepted into Law after the validation process with the book.Application of the Study: Customary Law has an indicator of moral constraints, so that applicable Law in general can also have indicators of moral limitations as customary Law.Originality/Novelty: Syara’ becomes a verification tool for morals in the customary Law of tau samawa and the book of Allah becomes a moral detector in the syara’ Keywords: Moral, Law, tradition, syara’
Paradigm of Legal Thought: Legal Prophetic Perspective
Authors: Hamdani Fitrah 
Published: August 2020

Objective: This article aims to discuss ‘criticism of legal prophetic paradigm against legal positivism paradigmMethodology: This research conducted a normative method used by legal positivists. This research is based on a philosophical approach as it is intended to explore the basic assumptions of the legal prophetic paradigm on the lack of the basic assumptions of the legal positivism paradigm.Findings: This paper will discuss the 'criticism of legal prophetic paradigm against legal positivism paradigm' using a philosophical approach as it is intended to explore the basic assumptions of the epistemology basis of the school of thought in legal science through comparison between the school of thoughts in legal science. The legal prophetic paradigm places moral as the main basis as its basic assumption. The verses of Allah and the Hadith of the Prophet regarding justice are the ontological basis of the Paradigm.Application of the Study: The object of legal science is human relations contained within (governed by) legal norms. Law science attempts to understand its object in a "legal" manner, which is from the legal perspective. Understanding something legally means understanding it as law, that is, as legal norms or as the content of legal norms or understanding something as determined by legal norms.Novelty/Originality: The prophetic paradigm can be approached through a Religion Science-based approach. The importance of this approach/religion science in understanding phenomenological law is none other but the occurrence of void or the broken links due to legal positivism thinking that is unable to play a functional role in presenting comprehensive legal justice. Keywords: Legal Positivism Paradigm, Legal Prophetic Paradigm, Basic Assumptions
The Implication of Innovation Management Against Unique Resources To Enhance The Business Performance of Small And Medium Enterprises (Sme) In Pasar Tanah Abang, Jakarta, Indonesia
Authors: Ramli Yanto 
Published: August 2020

The objective of this research is to analyze the business performance of the small and medium enterprises (SME) textile industries in Pasar Tanah Abang, Jakarta, Indonesia in order to find out how these SME industries can survive with the competition of thousands of SME in this area. This research is to analyze the implication of innovation management as the intervening variable that influence the unique resources and market orientation used by the SME industries to improve their business performance.
The collection of data is done through the distribution of questionnaire to the SME textile industries as the respondents in Pasar Tanah Abang, Jakarta, Indonesia. The method of analysis is based on descriptive and verification research, the sample determination is using Purposive Random Sampling and the data analysis is using Partial Least Square (PLS).
The results indicated that unique resources has the highest significant influence compare to market orientation on the business performance. Innovation also provides a significant influence on business performance, because either unique resources and market orientation have least value if they are not enhanced innovatively to obtain competitives advantage. Understanding the customer’s needs and wants and continue with develop innovatively the company resources can obtain competitive advantage to improve the small and medium enterprises garment industries business performance.