bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Chemical Proteomics Reveals Resveratrol Inhibition of A549 Cell Migration Through Binding Multiple Targets to Regulate Cytoskeleton Remodeling and Suppress EMT
Authors: Chen Xiao , Wang Yutong , Tian Jing , Shao Yurou , Zhu Bo , Wang Jigang , Hua Zichun 
Published: September 2020

Abstract
BackgroundResveratrol (RSV), a cancer chemopreventive natural product, has been shown to affect various cellular processes in tumor cells. However, RSV’s specific protein targets as well as its mechanism of action (MOA) of anticancer effect remain elusive. Recently, quantitative chemical proteomics approach has been an effective tool to identify target proteins, elucidate MOA and predict side effects for active small molecules, especially for natural products.MethodsThe pharmacological activity of RSV was evaluated in A549 cell lines, including the effects on cell proliferation and migration. To elucidate the underlying mechanism, a quantitative chemical proteomics approach was employed to identify the protein targets of RSV. With subsequent in vitro and in vivo experiments, RSV-related pathways and cellular processes were predicted and validated.ResultsRSV significantly inhibited A549 cell migration, but did not affect cell viability. With chemical proteomics approach, 38 target proteins were identified, and proteomic analysis showed that the targets were mainly involved in cytoskeleton remodeling and EMT, which were verified by subsequent in vitro and in vivo assays.ConclusionsRSV inhibits A549 cell migration through binding multiple targets to regulate cytoskeleton remodeling and suppress EMT.
Who will benefit most from lymph node dissection in invasive upper tract urothelial carcinoma: a matched case-control study
Authors: Li Zaishang , Li Xueying , Liu Ying , Xiao Kefeng 
Published: September 2020

Abstract
Background: Limited or regional lymphadenectomy (lymph node dissection, LND), which can help in postoperative risk stratification, is performed with radical nephroureterectomy (RNU). However, the specific ones are appropriate for LND in upper tract urothelial carcinoma (UTUC) has long been debated. We determined the clinical value of LND in different groups of UTUC patients who underwent RNU and someone who benefit most from LND in this study.Methods: Patients diagnosed with UTUC between 2004 and 2015 with available TNM stage classification were identified from 18 Surveillance, Epidemiology and End Results (SEER) registries. Propensity score analysis was used to match the baseline differences of patients. Results: This study included 5426 patients, and 2000 patients with invasive UTUC were matched (1000 patients with LND vs. 1000 patients without LND). The 5-year cancer-specific survival (CSS) estimate for the total cohort was 73.5%. After matching, the LND group had a higher 5-year CSS rate than the no-LND group (77.2% vs. 70.1%, P = 0.002). In heterogeneity analysis, there were significant differences between LND groups and no-LND in stage T4 (52.5% vs. 23.3%, P< 0.001), lymph node metastatic tumors (48.0% vs. 21.2%, P=0.015) and non-distant metastatic tumors (78.5% vs. 71.5%, P = 0.002). According to the most recent pathological prognostic groups classification, significant differences in survival were found between groups only with stage IV tumors (52.0% vs. 25.1%, P< 0.001). However, only stage T4NxM0 tumor patients were found a significant difference between LND groups in subgroup analysis (57.4% vs. 29.9%, P< 0.001). Conclusions:LND may improve the survival of invasive UTUC patients who undergo RNU, especially in T4NxM0 tumor patients. However, this hypothesis requires further confirmation.
Bacterial Distribution and Susceptibility in Bloodstream Infection in Primary-Care Hospital in Nova Friburgo, Rio de Janeiro
Authors: Schimidt Denise Braga , Conde Maria Eduarda Rocha , Silva Nayara de Almeida , Póvoa Helvecio Cardoso Corrêa 
Published: September 2020

Abstract
Human blood is sterile. When there is an infection, microorganisms can reach the bloodstream, which is known as bacteremia. This can be detected by blood culture. To study the prevalence of microorganisms isolated from blood culture samples. One hundred thirty-seven blood cultures were collected from hospitalized patients. All blood samples were processed for culture using a BACT/Alert blood culture machine. Further identification of bacterial pathogens and their antimicrobial susceptibility test were performed using standard microbiological procedures.Among these samples, 20.44% had a positive culture, 60.71% of which belonged to females and 39.29% were from male patients. The most common microorganisms found in positive blood cultures were coagulase negative Staphylococcus (33.33%), Staphylococcus aureus (23.33%), Klebsiella pneumoniae (6.70%), and Escherichia coli (6.66%). One sample showed an ESBL-producing E. coli. Gram-positive microorganisms were 100% susceptible to vancomycin and displayed considerable resistance to oxacillin. Many Gram-negative bacteria were resistant to cephalosporins.
Hypernatremia is common in patients with severe COVID-19 and indicates a poor prognosis
Authors: Sjöström Anna , Rysz Susanne , Sjöström Henrik , Höybye Charlotte 
Published: September 2020

Abstract
Background: Fluid homeostasis, including electrolyte balance, is dependent on an interaction between the renin-angiotensin-aldosterone system (RAAS) and the release of arginine vasopressin from the pituitary. An imbalance can lead to both hypo- and hypernatremia. We investigated the frequency, dynamics and severity of electrolyte imbalance in critically ill patients with COVID-19. Methods: In this retrospective cohort study 223 patients with confirmed COVID-19, treated at the intensive care unit (ICU), were included. Levels of electrolytes, base excess, pH and serum osmolality were collected from the laboratory database. Clinical data was retrieved from patients’ medical records.Results: Hyponatremia was present in 63% of the patients, at admission. Within two weeks of hospitalization, 65% of the patients developed hypernatremia often combined with a rise of base excess. The mortality rate was twice as high in the group with hypernatremia compared to the patients not developing hypernatremia. Treatment of hypertension before the onset of COVID-19 was more common in patients without hypernatremia.Conclusion: Our study shows that hypernatremia is very common in severe COVID-19. Patients that developed hypernatremia needed longer time in ICU and had a higher risk of dying, suggesting that the level of sodium is an important indicator of severity in COVID-19.
Developing and Optimising Observation and Monitoring Guidance for a Paediatric Early Warning System
Authors: Duncan Heather , Emms Karl , Eyre Caron , Hudson Adrienne 
Published: September 2020

Abstract
Background: Hospitalised children experience predictable and potentially preventable life-threatening events in hospital that may be reduced by early warning systems. With the current interest in developing a national PEW system, and in the absence of relevant literature, we present guidance from a mature programme that may be useful to those institutions that are currently planning implementation or modification of an existing system. Objectives: To develop an evidence and expert based observation and monitoring guidance as the standard and recommended practice underpinning a wider Paediatric Early Warning (PEW) system Design: Case study using mixed methods of literature reviews, consultation, focus groups and co-production. Setting: A specialist children’s hospital.Methods: This report outlines the development of the original guidance through consultation and co-production using a literature review and multi-professional focus groups and subsequent iterative changes. Results: The original (2008) and the current (2019) guidance are presented to show the modifications over time including ergonomic chart design, documenting parental concern, continuous monitoring, alarm management, fluid balance and hydration risk assessment, Sepsis 6, conditions to omit and de-escalate observations, and documentation of significant clinical events contemporaneously on the observation chart. Our guidance is compared to the Royal College of Nursing Guidance (2017), which includes good general guidance for performing routine observations correctly, but still limited guidance on the triage/ admission interface, frequency of routine observations, escalation and de-escalation of frequency and type of observations, and specialist observations.Conclusions: We have evolved evidence and expert based observation and monitoring guidance to support the implementation and maintenance of a PEW system over 12 years. The guidance sets standards of care to educate and guide clinicians and provides a template for assessment of that standard of care. TWEETABLE ABSTRACT Evidence and expert based observation and monitoring guidance to support the implementation and maintenance of a Paediatric Early Warning system.
VTR: an algorithm for identifying analogous contacts on protein structures and their complexes
Authors: Pimentel Vitor , Mariano Diego , Cantão Letícia Xavier Silva , Bastos Luana Luiza , Fischer Pedro , Lima Leonardo Henrique França de , Fassio Alexandre Victor , Melo-Minardi Raquel Cardoso de 
Published: September 2020

Abstract
Evolutionarily related proteins can present similar structures but very dissimilar sequences. Hence, understanding the role of the inter-residues contacts for the protein structure has been the target of many studies. Contacts comprise non-covalent interactions, which are essential to stabilize macromolecular structures such as proteins. Here we show VTR, a new method for the detection of analogous contacts in protein pairs. VTR performs structural alignment between proteins and detects interactions that occur in similar regions. To evaluate our tool, we proposed three case studies: (i) we compared a vertebrate myoglobin and a truncated invertebrate hemoglobin; (ii) analyzed interactions between the spike protein RBD of SARS-CoV-2 and the cell receptor ACE2; and (iii) compared a glucose-tolerant and a non-tolerant β-glucosidase enzyme used for biofuel production. The case studies demonstrate the potential of VTR for the understanding of functional similarities between distantly sequence-related proteins, as well as the exploration of important drug targets and rational design of enzymes for industrial applications. We envision VTR as a promising tool for understanding differences and similarities between homologous proteins with similar 3D structures but different sequences. VTR is available at http://bioinfo.dcc.ufmg.br/vtr.
Computation of Improved Searls Estimation of Population Variance Using Robust Auxiliary Parameters
Authors: Yadav S. K. , Sharma Dinesh K. , Alade Julius A. 
Published: September 2020

:Variation is an inherent phenomenon, whether in natural things or man-made. Thus, it seems essential to estimate this variation. Various authors have worked in the direction of improved estimation of population variance utilizing the known auxiliary parameters for better policymaking.Methods:In this article, a new Searls ratio type class of estimator is suggested for elevated estimation of population variance of the main variable. As the suggested estimator is biased, its bias and mean squared error (MSE) has been derived up to the order-one approximation. The optimum values for the Searls characterizing scalars are obtained. The minimum MSE of the introduced estimator is obtained for the optimum Searls characterizing scalars. A theoretical comparison between the suggested estimator and the competing estimators has been made through their mean squared errors. The efficiency conditions of the suggested estimator over competing estimators are also obtained. These theoretical conditions are verified using some natural data sets. The computation of R codes for the biases and MSEs of the suggested and competing estimators is developed and used for three natural populations in the study by Naz et al. The estimator with the least MSE is recommended for practical utility. The empirical study has been done using R programming.Results:The MSEs of different competing and the suggested estimators are obtained for three natural populations. The estimator under comparison with the least MSE is recommended for practical applications.Discussion:The aim to search for the most efficient estimator for improved estimation is fulfilled through the proper use of the auxiliary parameters obtained from the known auxiliary variable. The suggested estimator may be used for elevated estimation of the population variance.Conclusion:The introduced estimator has the least MSE as compared to competing estimators of population variance for all three natural populations. Thus, it may be recommended for application in various fields.
Enabling Remote Patient Monitoring Through the Use of Smart Thermostat Data in Canada: Exploratory Study
Authors: Sahu Kirti Sundar , Oetomo Arlene , Morita Plinio Pelegrini 
Published: September 2020

Background
Advances in technology have made the development of remote patient monitoring possible in recent years. However, there is still room for innovation in the types of technologies that are developed, used, and implemented. The smart thermostat solutions provided in this study can expand beyond typically defined features and be used for improved holistic health monitoring purposes.

Objective
The aim of this study is to validate the hypothesis that remote motion sensors could be used to quantify and track an individual’s movements around the house. On the basis of our results, the next step would be to determine if using remote motion sensors could be a novel data collection method compared with the national census-level surveys administered by governmental bodies. The results will be used to inform a more extensive implementation study of similar smart home technologies to gather data for machine learning algorithms and to build upon pattern recognition and comprehensive health monitoring.

Methods
We conducted a pilot study with a sample size of 8 to validate the use of remote motion sensors to quantify movement in the house. A large database containing data from smart home thermostats was analyzed to compare the following indicators; sleep, physical activity, and sedentary behavior. These indicators were developed by the Public Health Agency of Canada and are collected through traditional survey methods.

Results
The results showed a significant Spearman rank correlation coefficient of 0.8 (P<.001), which indicates a positive linear association between the total number of sensors activated and the total number of indoor steps traveled by study participants. In addition, the indicators of sleep, physical activity, and sedentary behavior were all found to be highly comparable with those attained by the Public Health Agency of Canada.

Conclusions
The findings demonstrate that remote motion sensors data from a smart thermostat solution are a viable option when compared with traditional survey data collection methods for health data collection and are also a form of zero-effort technology that can be used to monitor the activity levels and nature of activity of occupants within the home.
RETRACTED: The Role of Subject in Kuntowijoyo's Transformative Thought and It's Relevance to The Islamic Social Transformation
Authors: Khasri Muhammad Rodinal Khair 
Published: September 2020

Following a rigorous, carefully concerns and considered review of the article published in Jurnal Filsafat to article entitled “The Role of Subject in Kuntowijoyo's Transformative Thought and It's Relevance to The Islamic Social Transformation” Vol 30, No 2, pp. 261-286, 2020, DOI: https://doi.org/10.22146/jf.54911 This paper has been found to be in violation of the Jurnal Filsafat Publication principles and will be retracted.The article contained redundant material, the editor investigated and found that the paper published in “The Role of Subjects in Kuntowijoyo's Transformative Thought and It's Relevance to the Prophetical Social Transformation” Vol 4, No 2, pp. 126-144, August 2020, DOI: 10.22146/sasdayajournal.59662The document and its content will be removed from Jurnal Filsafat in the upcoming volume, and reasonable effort should be made to remove all references to this article.
Sobrepeso e inactividad física en universitarios de la ciudad de Barranquilla: un estudio descriptivo transversal
Authors: Nieto Ortiz Dolores , Nieto Mendoza Isaac , Torres Coronell Laura Isabel 
Published: September 2020

Introducción: la vida universitaria conduce a los estudiantes hacia un cambio en sus estilos de vida, con una tendencia hacia la inactividad física, que los hace propensos a padecer enfermedades crónicas no transmisibles y que se derivan también del sobrepeso.
Objetivo: caracterizar el nivel de actividad física e índice de masa corporal de estudiantes de la Facultad de Ciencias de la Educación de la Universidad del Atlántico.
Materiales y métodos: estudio descriptivo transversal, realizado a 131 universitarios a los que se les tomaron medidas antropométricas para el cálculo del índice de masa corporal y la valoración del nivel de actividad física a través del Cuestionario Internacional de Actividad Física.
Resultados: se encontró un promedio de edad de 22 años, un índice de masa corporal asociado al exceso de peso mayor en hombres (29 %) que en mujeres (25,5 %), y en el rango de edad de 18 a 22 años (29,7 %). En cuanto a la actividad física, los hombres (39,7 %) se ubicaron en el nivel bajo por encima de las mujeres (25,2 %); el rango de edad con mayores niveles de inactividad física fue entre 18 y 22 años (32,1 %).
Inhibición de la oxidación in vitro de lipoproteínas de baja densidad (LDL), por extractos acuosos de Camellia sinensis e Hibiscus sabdariffa
Authors: Pacheco Coello Franklin Jesús , Ramírez Azuaje Doralys Alessandra , Orosco Vargas Corymar Pastora , Peraza Marrero María Milagro , Coromoto Pinto Catari Ibis 
Published: September 2020

Introducción: el uso de bebidas funcionales como las infusiones de Camellia sinensis e Hibiscus sabdariffa, ha crecido en los últimos años a nivel mundial gracias a su contenido en compuestos bioactivos con un alto poder antioxidante, atribuyéndoles diversos efectos entre los que destaca su capacidad hipolipemiente.
Objetivo: el estudio tuvo como propósito evaluar la capacidad de dos extractos acuosos de C. sinensis e H. sabdariffa en la inhibición de la oxidación de las LDL obtenidas de plasma.
Material y métodos: se emplearon hojas de té verde orgánico y cálices deshidratados para la obtención de los extracto. Se determino el contenido de fenoles totales por el método de Folin-Ciocalteu y el ensayo de la oxidación de las LDL como modelo biológico para la evaluación de la capacidad inhibitoria de los extractos.
Resultados: se observó inhibición de la oxidación de las LDL por ambos extractos con diferencia estadística respecto al control (p≤0,05), siendo el extractos de C. sinensis el mayor actividad.
Conclusiones: las dos especies aportan un alto contenido de antioxidantes fundamentales para el organismo, por lo que la ingesta regulada y dirigida por expertos podría contribuir sin duda al tratamiento de hiperlipidemia.
KONTRAK TERAPEUTIK/ PERJANJIAN ANTARA DOKTER DENGAN PASIEN
Authors: Priyadi Aris 
Published: September 2020

Setiap manusia mendambakan hidup sehat, Menderita sakit adalah suatu hal yang tidak diharapkan, namun apabila suatu saat menderita sakit, maka sebagai upaya untuk menyembuhkan penyakit tersebut, salah satu alternatifnya adalah datang ke dokter atau rumah sakit dengan harapan mendapatkan pelayanan kesehatan untuk menyembuhkan penyakit yang diderita. Berdasarkan keahlian dokter, sesuai perkembangan ilmu dan teknologi kesehatan diharapkan dapat menyembuhkan penyakit tersebut. Dalam beberapa literatur disebutkan bahwa hubungan dokter dengan pasien itu disebut sebagai transaksi terapeutik, yaitu transaksi untuk mencari dan menerapkan terapi yang paling tepat untuk menyembuhkan pasien. Dokter sebelum melakukan upaya penyembuhan memerlukan adanya persetujuan pasien, yang dikenal dengan informed consent. Oleh karena ada hubungan atau perjanjian antara pasien dengan dokter/ rumah sakit maka berkaitan dengan hukum keperdataan akan tunduk/ terikat pada ketentuan hukum perdata yaitu tentang syarat–syarat sahnya perjanjian sebagaimana diatur dalam Pasal 1320 KUHPerdata. Dalam tulisan ini pembahasan akan difokuskan pada perbedaan pengertian informed consent dengan perjanjian/ transaksi terapeutik, berkaitan dengan objek perjanjian dalam perjanjian/ transaksi terapeutik berdasarkan ketentuan KUHPerdata serta apakah dalam perjanjian/ kontrak terapeutik tersebut para pihak dapat memutuskan secara sepihak
PERAN MAHKAMAH KONSTITUSI DALAM PEMILU
Authors: Dwiky Astawa Kadek 
Published: September 2020

Konstituai sebagai hukum tertinggi lahir sebagai untuk melindungi hak-hak asasi manusia. Konstitusi merupakan keseluruhan peraturan-peraturan baik tertulis maupun tidak tertulis yang mengatur secra mengikat tentang cara penyelenggaraan pemerintah dalam suatu negara. Dalam kaitanya hak warga negara dalam bidang politik, penyekenggaraan pemilu sangat erat kaitanya dengan persoalan HAM. Perlindungan HAM akan membawa suatu pemilu yang demokratis, Mahkamah Konstitusi yang melalui putusannya tentang berperan dalam suatu pelaku kekuasaan kehakiman yang memberikan perlindungan HAM. Mahkamah Kontitusi berfungsi sebagai pengawal dan penafsiran konstitusi, selain itu MK juga berfungsi sebagai pengawal demokrasi, perlindung hak konsitusional warga negara dan perlindungan HAM. Perlindungan hak asasi manusia merupakan salah satu fungsi dari MK yang merupakan konsekuensi dari keberadaan HAM sebagai materi muatan konsitusi. Dalam melindungi HAM, MK dapat melihat pada beberapa putusan baik dalam perkara pengujian Undang-undang maupun perselisihan hasil pemilu diantaranya adalah pemulihan hak pilih bekas anggota PKI, hak pilih mantan narapidana tertentu, pemberian hak pencalonan kepada parati non parlemen, hak percalonan kepada perseorangan dalam pemilukada, perlindungan hak bagi pertahanan, hak pilih ancaman dan terror, perlindungan hak mencalnkan diri tindakan yang menghambat, serta pengakuan terhadap cara yang diakui oleh hukum adat.
KONSEP PENDIDIKAN ANTI-TERORISME Relevansinya bagi Pendidikan Islam
Authors: Marianti Marianti 
Published: September 2020

Penelitian ini dilatarbelakangi oleh adanya fenomena terorisme yang sudah tumbuh subur di Indonesia. Karena sebagian besar masyarakat Indonesia memeluk agama Islam, maka dari sekian deretan aksi kekerasan dan aksi terorisme di negeri ini, pelakunya tidak lain adalah kalangan muslim. Padahal secara normatif, Islam merupakan kepercayaan open minded dan inklusif yang mengajarkan kedamaian (rahmatan lil âlamîn). Secara konseptual, pendidikan anti terorisme di dasarkan pada; Pertama, Falsafah pendidikan Anti Terorismem, yaitu proses pengenalan dan pemberian informasi akan nilai-nilai anti terorisme, dengan harapan membantu peserta didik untuk menjadi manusia yang bermoral, berwatak serta bertanggung jawab dalam rangka membangun hidup bermasyarakat dan berbangsa. Kedua, Aqidah Inklusif Sebagai Pijakan Pendidikan Anti Terorisme, yaitu menumbuhkan saling menghormati kepada semua manusia yang memiliki mazhab atau keyakian yang berbeda dalam beragama. Adapun nilai-nilai pendidikan anti terorisme adalah Toleransi, Nirkekerasan, dan Pluralisme. Sedangkan pandangan Islam terhadap Pendidikan Anti-Terorime adalah tercermin pada 4 (empat) isu pokok yang dipandang sebagai dasar pendidikan anti terorisme, yaitu : Pertama, kesatuan dalam aspek ketuhanan dan pesan-Nya (wahyu); Kedua, kesatuan kenabian; Ketiga, tidak ada paksaan dalam beragama; dan Keempat, pengakuan terhadap eksistensi agama lain.