bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic collapse capacity assessment of SDOF systems incorporating duration and instability effects
Authors: Bravo-Haro M. A. , Liapopoulou M. , Elghazouli A. Y. 
Published: March 2020

AbstractThis paper presents a detailed investigation into the seismic response of non-deteriorating and deteriorating single degree-of-freedom systems controlled by $$P -\Delta$$P-Δ effects, with due account for the influence of earthquake duration. In order to isolate the effect of duration from other ground motion characteristics, 77 pairs of records with equivalent spectral shapes are considered in the study. The structural characteristics examined include the structural period, applied gravity loading, post-yield stiffness, viscous damping, material hysteretic behaviour, as well as the level of cyclic deterioration within the pinching systems. Detailed incremental dynamic analyses are carried out, considering an intensity measure corresponding to the spectral acceleration at the structural period of vibration of the system. Based on the incremental dynamic analysis results, predictive relationships are proposed for determining the structural collapse capacity, accounting for the influence of key parameters including instability and duration effects. The median and dispersion of the collapse capacity distribution embedded in the predictive models are also presented. The effect of duration is shown to increase with longer structural periods and to decrease with higher $$P -\Delta$$P-Δ levels. The more rapid instigation of dynamic instability in relatively stiff systems is also shown to reduce their comparative sensitivity to variations in ground motion characteristics. Overall, it is indicated that disregarding the influence of duration could lead to over-estimations of up to 50% in the collapse capacity. The paper concludes with a discussion of other sources of structural damage that instigate collapse when using records with equivalent spectral shape but without especial consideration for duration effects.
Polysiloxane Derived Macroporous Silicon Oxycarbide Microspheroidal Particles and Their Decoration with 1D Structures
Authors: Fortuniak W. , Chojnowski J. , Mizerska U. , Pospiech P. , Zakrzewska J. , Slomkowski S. 
Published: March 2020

AbstractA simple method of synthesis for the macroporous SiOC spheroidal microparticles was developed. Preceramic polysiloxane macroporous microbeads were obtained by a one-step aqueous emulsion process involving poly(hydromethylsiloxane) (PHMS) with the addition of FeCl3·6H2O. Thermal treatment of these particles gave various SiOC materials depending on the pyrolysis temperature. Hierarchically porous spheroidal mezo-macroporous ceramers were obtained at 600 °C. Heating at 850–1000 °C gave SiOC ceramic spheroidal particles with about 60% open porosity. Ceramization at 1200–1400 °C led to the particles decorated with ceramic whiskers and wires. Heating at 1600 °C gave wires and spilled ceramic particles. These 1D ceramic structures were formed by a Vapor–Liquid–Solid (VLS) mechanism.
Language policy, ideological clarification and theory of mind
Authors: Albury Nathan John 
Published: March 2020

AbstractThis interdisciplinary paper shows that investigating community language beliefs, as a pillar of language policy research, can be enriched by the principles of theory of mind. The case study is Malaysia where ethnonationalist law and policy elevates the language and culture of the Muslim Malay majority above those of citizens of Chinese and Indian ethnicity, but where a seismic political shift is underway. The re-election of Dr Mahathir Mohammad as prime minister in May 2018, but now standing for Pakatan Harapan, broke decades of rule by the traditionalist United Malays National Organisation. Promises are being made to bring an end to Malaysia’s race-based politics and foster equality. The situation is ripe for producing contentious and politically-embedded talk in the community about Malaysia’s linguistic diversity and ethnonationalist language policy. In that context, this paper analyses how youths from different ethnic groups feel about Malaysia’s societal multilingualism. However, the innovation is in then soliciting and analysing the hypotheses of these same youths about how their own heritage languages, as well as societal multilingualism and language policy, are perceived by the other ethnic groups. As Malaysia embarks on political change, exploring beliefs in these interethnic multidirectional terms reveals fissures and alignments between beliefs that are articulated by different youths and the beliefs that are attributed to them. This methodological approach can support language policy processes and research by more richly investigating language beliefs and ideological positioning from multidirectional vantage points.
Ceramide and palmitic acid inhibit macrophage-mediated epithelial–mesenchymal transition in colorectal cancer
Authors: de Araujo Junior Raimundo Fernandes , Eich Christina , Jorquera Carla , Schomann Timo , Baldazzi Fabio , Chan Alan B. , Cruz Luis J. 
Published: March 2020

AbstractAccumulating evidence indicates that ceramide (Cer) and palmitic acid (PA) possess the ability to modulate switching of macrophage phenotypes and possess anti-tumorigenic effects; however, the underlying molecular mechanisms are largely unknown. The aim of the present study was to investigate whether Cer and PA could induce switching of macrophage polarization from the tumorigenic M2- towards the pro-inflammatory M1-phenotype, and whether this consequently altered the potential of colorectal cancer cells to undergo epithelial–mesenchymal transition (EMT), a hallmark of tumor progression. Our study showed that Cer- and PA-treated macrophages increased expression of the macrophage 1 (M1)-marker CD68 and secretion of IL-12 and attenuated expression of the macrophage 2 (M2)-marker CD163 and IL-10 secretion. Moreover, Cer and PA abolished M2 macrophage-induced EMT and migration of colorectal cancer cells. At the molecular level, this coincided with inhibition of SNAI1 and vimentin expression and upregulation of E-cadherin. Furthermore, Cer and PA attenuated expression levels of IL-10 in colorectal cancer cells co-cultured with M2 macrophages and downregulated STAT3 and NF-κB expression. For the first time, our findings suggest the presence of an IL-10-STAT3-NF-κB signaling axis in colorectal cancer cells co-cultured with M2 macrophages, mimicking the tumor microenvironment. Importantly, PA and Cer were powerful inhibitors of this signaling axis and, consequently, EMT of colorectal cancer cells. These results contribute to our understanding of the immunological mechanisms that underlie the anti-tumorigenic effects of lipids for future combination with drugs in the therapy of colorectal carcinoma.
Towards the Ethical Publication of Country of Origin Information (COI) in the Asylum Process
Authors: Aggarwal Nikita , Floridi Luciano 
Published: March 2020

AbstractThis article addresses the question of how ‘Country of Origin Information’ (COI) reports—that is, research developed and used to support decision-making in the asylum process—can be published in an ethical manner. The article focuses on the risk that published COI reports could be misused and thereby harm the subjects of the reports and/or those involved in their development. It supports a situational approach to assessing data ethics when publishing COI reports, whereby COI service providers must weigh up the benefits and harms of publication based, inter alia, on the foreseeability and probability of harm due to potential misuse of the research, the public good nature of the research, and the need to balance the rights and duties of the various actors in the asylum process, including asylum seekers themselves. Although this article focuses on the specific question of ‘how to publish COI reports in an ethical manner’, it also intends to promote further research on data ethics in the asylum process, particularly in relation to refugees, where more foundational issues should be considered.
High-dimensional changepoint detection via a geometrically inspired mapping
Authors: Grundy Thomas , Killick Rebecca , Mihaylov Gueorgui 
Published: March 2020

AbstractHigh-dimensional changepoint analysis is a growing area of research and has applications in a wide range of fields. The aim is to accurately and efficiently detect changepoints in time series data when both the number of time points and dimensions grow large. Existing methods typically aggregate or project the data to a smaller number of dimensions, usually one. We present a high-dimensional changepoint detection method that takes inspiration from geometry to map a high-dimensional time series to two dimensions. We show theoretically and through simulation that if the input series is Gaussian, then the mappings preserve the Gaussianity of the data. Applying univariate changepoint detection methods to both mapped series allows the detection of changepoints that correspond to changes in the mean and variance of the original time series. We demonstrate that this approach outperforms the current state-of-the-art multivariate changepoint methods in terms of accuracy of detected changepoints and computational efficiency. We conclude with applications from genetics and finance.
Thermal Behaviour of Synovene and Oleamide in Oil Adsorbed on Steel
Authors: Casford Michael T. L. , Puhan Debashis , Davies Paul B. , Bracchi Gareth L. , Smith Tony D. 
Published: March 2020

AbstractOleamide and Synovene lubricant additives when mixed together show a clear co-operative effect leading to friction and wear reduction. Sum Frequency Generation vibrational spectroscopy has been used to record in situ spectra of these additives with the aim of understanding the behaviour of these molecules when adsorbed on steel immersed in a model base oil at pre-selected temperatures. The spectra of the individual components and of mixtures have been recorded up to 130 °C. Individual spectra from both molecules have been distinguished using per-deuterated oleamide. The temperature at which maximum ordered adsorption of pure Synovene molecules occurs drops from ~ 130 to ~ 70 °C in the mixture with oleamide. Our results show that co-adsorption occurs, which causes a change in net polar orientation of the oleamide component suggesting the hydrocarbon chains of the oleamide molecules reverse their polar orientation when Synovene is present. The net effect of co-adsorption and change in orientation as well as conformation of the two molecules could explain the reduction of friction and wear observed at the metal–metal interface.
Effects of a 4 week touch rugby and self-paced interval running intervention on health markers in active young men
Authors: Dobbin Nick , Bloyce Daniel , Hughes Stephen Fȏn , Twist Craig 
Published: March 2020

Abstract
Background
Modified team sport activity has been proposed as effective exercise modality for promoting markers of health that are comparable or greater than continuous forms of activity. However, research using modified team sports is currently limited to sedentary populations using 2–3 sessions across a minimum of 8 weeks.

Aim
To investigate the effects of a 4-week touch rugby and self-paced interval running intervention on a range of health markers in active men.

Methods
Sixteen participants (age 26.4 ± 6.4 years) were matched for age, demographic and physical activity before completing a single touch rugby (n = 8) or running (n = 8) session per week for 4 weeks. Measures of systolic and diastolic blood pressure, resting heart rate (RHR), body composition and biochemical status were recorded pre- and post-intervention.

Results
ANCOVA analysis revealed between-group differences for impedance (P = 0.027), fat mass (P = 0.008), percentage body fat (P = 0.008) and fat-free mass (P = 0.002), with greater changes after touch rugby. Systolic blood pressure decreased for both groups with greater reductions observed after touch rugby (P = 0.002). No between-group difference was observed for RHR, interleukin-6 or C-reactive protein (P > 0.05). Contrasting internal, external and perceptual loads were observed.

Conclusion
The results of this study suggest that a single session of touch rugby over a 4-week period elicited greater improvements in body composition and SBP than self-paced running, with both being equally beneficial for improving RHR, diastolic blood pressure and inflammatory status in active young men.
Balancing act between research and application: how research orientation and networks affect scholars’ academic and commercial output
Authors: Werker Claudia , Hopp Christian 
Published: March 2020

AbstractScholars’ balancing act between research and application leads to trade-offs between commercial and research output. Yet what some scholars may consider as poles apart might lead to super-additive outcomes for others. Based on a survey carried out at three leading European universities of technology we investigate the influence of scholars’ research orientation and networks on their output productivity. Our results point to a very specific group of ambidextrous scholars that is comparatively small. The scholars in this group are able to successfully balance research and application. In contrast, all scholars focusing on either pure basic or pure applied research face a trade-off between publications and innovations. In general, our findings suggest that the output productivity of all scholars is the higher the better their research orientation fits with their network activities. In particular, ambidextrous scholars rely on effectively accessing and utilizing their network to increase commercial and research output.
Transdisciplinarity: science for and with society in light of the university’s roles and functions
Authors: Scholz Roland W. 
Published: March 2020

AbstractThe idea that universities should become entrepreneurial, commercialized, private commodities or should serve politicians and governmental agencies has been promoted by the university–industry–government relationship-based Triple Helix approach and is reality in many places. In contrast, a reemphasis on universities serving the public good has been demanded by proponents of transdisciplinary sustainability research. To better understand the tensions between public-good–oriented approaches of transdisciplinarity and entrepreneurial, market-oriented Triple Helix and third-mission approaches of science—practice collaboration, this paper takes a closer look at the history of universities’ roles and functions. We then elucidate the practice of transdisciplinary processes and discuss the “science for and with society” approach of transdisciplinary sustainable transitioning. We argue that transdisciplinarity for producing groundbreaking sociotechnical solutions has to serve (a) the public good and (b) calls for independence, academic freedom, institutionalization, and proper funding schemes. Third-mission conceptions that follow the commercialization/capitalization of scientific knowledge are in conflict with the conception of science and of transdisciplinarity serving sustainable transitioning. The development of groundbreaking ideas for sustainable transitions must acknowledge the complexity and contextualization of real-world settings. Therefore, collaboration between practice and transdisciplinarity calls for the input and cooperation of authentic practitioners, i.e., the experts of practice and real wold complexity. The challenge of transdisciplinarity is to properly relate the fundamental expertise of practice to validated academic rigor. This implies that transdisciplinary research is a critical element of the university’s research mission.
Knockdown of Arginyl-tRNA Synthetase Attenuates Ischemia-Induced Cerebral Cortex Injury in Rats After Middle Cerebral Artery Occlusion
Authors: Liu Yang , Hu Xue-Bin , Zhang Li-Zhi , Wang Zi , Fu Rong 
Published: March 2020

AbstractSome researchers have previously shown that RNAi knockdown of arginyl-tRNA synthetase (ArgRS) before or after a hypoxic injury can rescue animals from death, based on the model organism, C. elegans. However, there has been no study on the application of arginyl-tRNA synthetase knockdown in treating mammalian ischemic stroke, and its potential mechanism and effect on ischemic brain damage are still unknown. Here, we focused on the Rars gene, which encodes an arginyl-tRNA synthetase, and examined the effects of Rars knockdown in a permanent middle cerebral artery occlusion model in rats. To achieve this aim, adult male Sprague-Dawley (SD) rats were given right cerebral cortex injections of short hairpin RNA (shRNA) adenovirus (AV) particles to knock down arginyl-tRNA synthetase, and a non-targeting control (NTC) vector or phosphate-buffered solution served as the controls. After 4 days, the rats were exposed to permanent middle cerebral artery occlusion (pMCAO). Then, the right cerebral cortex level of arginyl-tRNA synthetase was examined, and the effects of the Rars knockdown were evaluated by differences in infarction volume, oxidative stress, blood-brain barrier, mitochondrial function, and glucose metabolism at 1 day and 3 days after MCAO. The injection of shRNA adenovirus particles successfully suppressed the expression of arginyl-tRNA synthetase in the cerebral cortex. We observed an improvement in oxidative stress, mitochondrial function, and glucose utilization and a reduction in brain edema compared with the non-targeting control rats with suppressed expression of arginyl-tRNA synthetase mRNA in the ipsilateral ischemic cortex of the brain. Our findings indicate that knockdown of arginyl-tRNA synthetase in the cerebral cortex exerted neuroprotective effects, which were achieved not only by the improvement of oxidative stress and glucose utilization but also by the maintenance of mitochondrial morphological integrity and the preservation of mitochondrial function. Knockdown of ArgRS administration could be a promising approach to protect ischemic stroke.
Sectoral evolution and shifting service delivery models in the sharing economy
Authors: Mahmuda S. , Sigler T. , Knight E. , Corcoran J. 
Published: March 2020

AbstractThe rise of the sharing economy has had transformative impacts on extant service delivery models, with wide ranging implications for existing firms, regulators, and the workforce at large. This paper draws upon firm-level data to better understand how new forms of service delivery have accompanied the diffusion of the sharing economy. Unlike previous waves of technological innovation, sharing economy firms have emerged as digital intermediaries rather than direct service providers driven by shifting consumer practices and attitudes. We apply an innovation diffusion model to trace the development trajectory of the sharing economy across 1000 firms. Our model segments the evolution of the sharing economy into three distinct and overlapping phases, comprising an Embryonic Stage (1995–2008), an Early Growth Stage (2007–2015), and most recently a Late Growth Stage (2014–present). Analysis of the 1000 firms reveals that the sharing economy has rapidly gained momentum across all industry sectors, with its growth trajectory principally tied to the evolution of related financial and technological innovations paralleled by social adoption. We find that service delivery models differ considerably between sectors, with professional services favouring business-oriented models, and consumables oriented more towards peer sharing. Though peer-to-peer (P2P) has been the dominant model, this is changing as larger firms enter the market and existing firms become industry leaders. We argue that while the marginal cost of new transactions within a P2P structure is low, barriers to market entry become ever-higher as sharing economy service delivery models are increasingly embedded within the mainstream economy.
On the Direct Reduction Phenomena of Bauxite Ore Using H2 Gas in a Fixed Bed Reactor
Authors: Lazou Adamantia , van der Eijk Casper , Balomenos Efthymios , Kolbeinsen Leiv , Safarian Jafar 
Published: March 2020

AbstractThe Bayer Process is the dominant industrial method to produce alumina from bauxite ore. Due to the generation of large amounts of Bauxite Residue (red mud), an alternative method, called the Pedersen Process, is of our interest. This process makes use of a combination of pyrometallurgical and hydrometallurgical techniques in order to prevent the Bauxite Residue generation. In the conventional Pedersen Process, iron in the bauxite is separated in the form of pig iron through a carbothermic smelting-reduction step which has a CO2 emission similar to that during conventional iron production. In order to eliminate the CO2 emission of this step, the focus of the present work is to reduce the iron oxides of bauxite ore by hydrogen gas (H2) prior to smelting and minimizing the use of solid carbon materials for the reduction. The thermochemistry and the kinetics of reactions during calcination and direct reduction of a bauxite ore were studied by a thermogravimetric technique and in situ analysis of the gaseous products. The onset temperatures for the decomposition of bauxite components during calcination were determined. The kinetics of the reduction of hematite to metallic iron was studied and it is shown that the reduction of iron oxides to metallic iron starts at temperatures below 560 °C and it accelerates at higher temperatures. Moreover, it is indicated that the formation of hercynite (FeAl2O4) phase retards the complete reduction at temperatures higher than 760 °C.
Availability of Male and Female Sexual Health and Fertility Information on National Cancer Institute–Designated Cancer Center Websites
Authors: Shah Tejash , Shin David 
Published: March 2020

Abstract

Introduction
For the estimated 15 million cancer survivors in the United States, access to accurate information regarding quality of life issues such as sexual health and fertility preservation is a very important part of cancer recovery.

Aim
Because National Cancer Institute (NCI)–designated cancer centers (CCs) are leaders of cancer care, we sought to determine the prevalence and quality of information relating to male and female sexual health and fertility on all NCI-designated CC websites.

Methods
A total of 70 NCI-designated CC websites listed on www.cancer.gov and divided by geographic regions were carefully analyzed for the presence and quality of male and female sexual health and fertility information. Fisher’s exact test was performed to assess for differences between websites.

Main Outcome Measure
We determined the number and percentage of NCI-designated CC websites with sexual health and/or fertility information, availability of information by region, and information available for each gender.

Results
Sexual health and/or fertility information was accessible on 43 of 63 (68.3%) CC websites and was more prevalent on comprehensive CC compared with non-comprehensive CC websites (37 of 49 [75.5%] vs 6 of 14 [42.9%] websites, respectively; P &lt; .05). NCI-designated CC websites had less information on sexual health compared with that on fertility (24 of 63 [38.1%] vs 41 of 63 [65.1%] websites, respectively; P &lt; .01). Access to data was less available for men compared with women (35 of 41 [85.4%] vs 41 of 41 [100%] websites, respectively; P &lt; .05) on CC websites providing fertility preservation information. Fifteen CCs in the South Atlantic (11) and East South Central (4) regions did not offer sexual health information on their respective websites.

Conclusion
Information regarding sexual health and fertility preservation after cancer treatment is not common and less available for men compared with women on NCI-designated CC websites. The aforementioned data highlight the need to improve the quality and accessibility of sexual health and fertility preservation information for all NCI-designated CC websites.