bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospecção e Maturidade Tecnológica da PI0805516-5 para o Gerenciamento da Transferência da Tecnologia
Authors: Almeida Borges Mendonça Polyana , Duarte Avena de Castro Ana Paula , Ribeiro Mariana , Ferreira Eduardo Antonio , Barboni Dantas Nascimento Paulo Gustavo 
Published: October 2020

<p> </p><p class="Pargrafo" style="margin-bottom: 4.5pt;">Este estudo propõe uma avaliação tecnológica do pedido de patente PI0805516-5, de propriedade da Universidade de Brasília (UnB). A tecnologia se refere aos extratos, seus derivados e aos processos de obtenção desses materiais vegetais, incluindo ativos dele isolado, de plantas do gênero <em style="mso-bidi-font-style: normal;">Pouteria</em> e seu emprego na composição de medicamentos, suplementos alimentares ou composições nutracêuticas.<span style="mso-spacerun: yes;"> </span>A metodologia utilizada no estudo foi a bibliometria, a <span style="mso-bidi-font-style: italic;">Technology Readiness Level</span> (TRL), a Technology Roadmap (TRM) e a Matriz SWOT, sigla em inglês das palavras <em style="mso-bidi-font-style: normal;">Strenghts, <span style="color: black; mso-color-alt: windowtext; background: white;">Weaknesses, Opportunities e Threats, </span></em><span style="color: black; mso-color-alt: windowtext; background: white;">(Forças, Fraquezas, Oportunidades e Ameaças). </span>A maturidade da tecnologia analisada resultou em um nível que demanda mais pesquisas até que esteja pronta para ser transferida para o mercado, que poderá ser acessado por meio da modalidade de <em style="mso-bidi-font-style: normal;">know-how</em>, uma vez que a concessão de patente para materiais biológicos não é viável, conforme prevê a Lei n. 9.279/96.</p><p></p>
Long noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF‐κB/YY1 axis
Authors: Liu Jia , Zhan Yang , Wang Jiefu , Wang Junfeng , Guo Jiansheng , Kong Dalu 
Published: October 2020

Metastasis accounts for poor prognosis of cancers and related deaths. Accumulating evidence has shown that long noncoding RNAs (lncRNAs) play critical roles in several types of cancer. However, which lncRNAs contribute to metastasis of colon cancer is still largely unknown. In this study, we found that lncRNA LINC01578 was correlated with metastasis and poor prognosis of colon cancer. LINC01578 was upregulated in colon cancer, associated with metastasis, advanced clinical stages, poor overall survival, disease‐specific survival, and disease‐free survival. Gain‐of‐function and loss‐of‐function assays revealed that LINC01578 enhanced colon cancer cell viability and mobility in vitro and colon cancer liver metastasis in vivo. Mechanistically, nuclear factor kappa B (NF‐κB) and Yin Yang 1 (YY1) directly bound to the LINC01578 promoter, enhanced its activity, and activated LINC01578 expression. LINC01578 was shown to be a chromatin‐bound lncRNA, which directly bound NFKBIB promoter. Furthermore, LINC01578 interacted with and recruited EZH2 to NFKBIB promoter and further repressed NFKBIB expression, thereby activating NF‐κB signaling. Through activation of NF‐κB, LINC01578 further upregulated YY1 expression. Through activation of the NF‐κB/YY1 axis, LINC01578 in turn enhanced its own promoter activity, suggesting that LINC01578 and NF‐κB/YY1 formed a positive feedback loop. Blocking NF‐κB signaling abolished the oncogenic roles of LINC01578 in colon cancer. Furthermore, the expression levels of LINC01578, NFKBIB, and YY1 were correlated in clinical tissues. Collectively, this study demonstrated that LINC01578 promoted colon cancer metastasis via forming a positive feedback loop with NF‐κB/YY1 and suggested that LINC01578 represents a potential prognostic biomarker and therapeutic target for colon cancer metastasis.
Development of distributed multiple‐source and multiple‐use heat pump system using renewable energy: Outline of test building and experimental evaluation of cooling and heating performance
Authors: Liu Mingzhe , Hino Toshiyuki , Ooka Ryozo , Wen Ke , Choi Wonjun , Lee Doyun , Ikeda Shintaro 
Published: October 2020

AbstractThe development of a distributed heat pump system that utilizes several renewable energy sources to meet building heating and cooling demands was reported in this paper. We refer to this system as the multiple‐source and multiple‐use heat pump (MMHP) system. A unique sky source heat pump, ground heat exchangers, and various heat pumps are connected through closed‐loop piping system within a building. This kind of configuration enables improved matching of supply and demand which offers a high flexibility. The winter and summer field testing are conducted to investigate the system performance using a testing building.
A Novel Heterostructure Based on RuMo Nanoalloys and N‐doped Carbon as an Efficient Electrocatalyst for the Hydrogen Evolution Reaction
Authors: Tu Kejun , Tranca Diana , Rodríguez‐Hernández Fermín , Jiang Kaiyue , Huang Senhe , Zheng Qi , Chen Ming‐Xi , Lu Chenbao , Su Yuezeng , Chen Zhenying , Mao Haiyan , Yang Chongqing , Jiang Jinyang , Liang Hai‐Wei , Zhuang Xiaodong 
Published: October 2020

AbstractHeterostructures exhibit considerable potential in the field of energy conversion due to their excellent interfacial charge states in tuning the electronic properties of different components to promote catalytic activity. However, the rational preparation of heterostructures with highly active heterosurfaces remains a challenge because of the difficulty in component tuning, morphology control, and active site determination. Herein, a novel heterostructure based on a combination of RuMo nanoalloys and hexagonal N‐doped carbon nanosheets is designed and synthesized. In this protocol, metal‐containing anions and layered double hydroxides are employed to control the components and morphology of heterostructures, respectively. Accordingly, the as‐made RuMo‐nanoalloys‐embedded hexagonal porous carbon nanosheets are promising for the hydrogen evolution reaction (HER), resulting in an extremely small overpotential (18 mV), an ultralow Tafel slope (25 mV dec−1), and a high turnover frequency (3.57 H2 s−1) in alkaline media, outperforming current Ru‐based electrocatalysts. First‐principle calculations based on typical 2D N‐doped carbon/RuMo nanoalloys heterostructures demonstrate that introducing N and Mo atoms into C and Ru lattices, respectively, triggers electron accumulation/depletion regions at the heterosurface and consequently reduces the energy barrier for the HER. This work presents a convenient method for rational fabrication of carbon–metal heterostructures for highly efficient electrocatalysis.
Workplace‐based Assessment Data in Emergency Medicine: A Scoping Review of the Literature
Authors: Chan Teresa M. , Sebok‐Syer Stefanie S. , Cheung Warren J. , Pusic Martin , Stehman Christine , Gottlieb Michael 
Published: October 2020

AbstractObjectiveIn the era of competency‐based medical education (CBME), the collection of more and more trainee data is being mandated by accrediting bodies such as the Accreditation Council for Graduate Medical Education and the Royal College of Physicians and Surgeons of Canada. However, few efforts have been made to synthesize the literature around the current issues surrounding workplace‐based assessment (WBA) data. This scoping review seeks to synthesize the landscape of literature on the topic of data collection and utilization for trainees’ WBAs in emergency medicine (EM).MethodsThe authors conducted a scoping review in the style of Arksey and O’Malley, seeking to synthesize and map literature on collecting, aggregating, and reporting WBA data. The authors extracted, mapped, and synthesized literature that describes, supports, and substantiates effective data collection and utilization in the context of the CBME movement within EM.ResultsOur literature search retrieved 189 potentially relevant references (after removing duplicates) that were screened to 29 abstracts and papers relevant to collecting, aggregating, and reporting WBAs. Our analysis shows that there is an increasing temporal trend toward contributions in these topics, with the majority of the papers (16/29) being published in the past 3 years alone.ConclusionThere is increasing interest in the areas around data collection and utilization in the age of CBME. The field, however, is only beginning to emerge, leaving more work that can and should be done in this area.
Monthly endoscopy surveillance culture facilitates detection of breaches in the scope reprocessing procedure: 5‐year experience in an endoscopy center
Authors: Chen Shu‐Hui , Liu Theophile , Lai Huei‐Wen , Chang Hui‐Lan , Yen Hsu‐Heng 
Published: October 2020

AbstractThe aim of this study is to review the clinical impact of monthly microbiology surveillance culture for monitoring endoscope contamination after high‐level disinfection. Monthly surveillance culture of the endoscopes was conducted from January 2014 to December 2018 at our endoscopy center. A total of 1931 cultures were collected, including 765 cultures from 16 gastroscopes, 730 cultures from 18 colonoscopes, 379 cultures from 8 duodenalscopes, 46 cultures from 1 echoscopes, and 11 cultures from 1 enterscope. Cultures were obtained from ready‐to‐use endoscopes after a full reprocessing cycle and storage. Samples were cultured to test for aerobic and anaerobic bacteria. The positive culture rates for the endoscope were 2% (15/765) for gastroscopes, 1.9% (14/730) for colonoscopes, 0.8% (3/379) for duodenscopes, 4.3% (2/46) for echoscopes, and 9.1% (1/11) for enterscopes. These findings were predominantly attributed to human factors (71.4%, 25/35) followed by storage cabinet failure (14.3%, 5/35), automatic endoscope reprocessing failure (11.4%, 4/35), and endoscope channel damage (2.8%, 1/35). Multivariate analysis showed that the years 2015 (odds ratio [OR] 0.19, 0.04 to 0.91), 2016 (OR 0.21, 0.05 to 0.80), and 2017 (OR 0.22, 0.06 to 0.83) were associated with decreased risk of endoscope contamination. The age, type, and number of times the scope was used were not related to contamination. A low risk of endoscope contamination was found over a 5‐year period in our endoscopy center. The most common cause of contamination was human factor. Duodenalscopes showed the lowest scope contamination rate. We suggested the implantation of a systematic endoscope culture regardless of the type of scope to facilitate early detection of breaches in the scope reprocessing procedure in clinical practice.
Stevens‐Johnson syndrome: A rare complication of esomeprazole
Authors: Wu Tung‐Lung , Chou Kun‐Ching , Yen Hsu‐Heng 
Published: October 2020

AbstractProton pump inhibitor (PPI) is a commonly prescribed drug for peptic ulcer. Serious adverse events, such as Stevens‐Johnson syndrome (SJS), are very rare. A 58‐year‐old man had been experiencing tarry stools and endoscopic evaluation revealed active duodenal ulcer bleeding. After the failure of endoscopic therapy, arterial embolization resulted in successful hemostasis. The patient was administered PPI to prevent recurrent ulcer bleeding. High fever and generalized skin rash developed on hospital day 16 and subseqnent evaluation suggested esomeprazole associated SJS. Although rare, clinicians should be aware of this rare cutaneous complication of PPI. Early recognition and cessation of PPI can help prevent this lethal complication.
An unusual cause of lower gastrointestinal bleeding
Authors: Chen Chi‐Jen , Tsai Ying‐Nan , Chang I‐Wei , Yang Chung‐Yi , Tai Chi‐Ming 
Published: October 2020

AbstractAcute lower gastrointestinal (GI) bleeding refer to blood loss of colon origination. The cause of lower GI bleeding may include vascular (ulcer, angiodysplasia, ischemic, or radiation), anatomic (diverticulum), inflammatory (ulcerative colitis, Crohn's disease), infectious, or neoplastic. Mesenteric venous thrombosis is responsible for 5% to 15% of all mesenteric ischemic events, and the involvement of the inferior mesenteric vein (IMV) is rare. A 70‐year‐old man who presented with episodes of bloody diarrhea. Colonoscopy revealed diffuse hyperemic changes in the rectum and sigmoid colon. A contrast‐enhanced computed tomography showed diffuse, circumferential wall thickening of the descending colon, sigmoid colon, and rectum as a result of thrombosis in the IMV. Anticoagulant was administered and there was no further bloody diarrhea. Mesenteric venous thrombosis is a rare cause of lower GI bleeding. However, it may be kept in mind in high risk populations such as malignancy, prothrombotic states, inflammatory bowel disease, recent abdomen injury or surgery, and diabetes mellitus.
Bowel mucosal necrosis and perforation following administration of calcium polystyrene sulfonate (Kalimate) in patients with hyperkalemia: Report of two cases
Authors: Shen Chang‐Ping , Chen Li‐Wei , Chang Liang‐Che , Jhu Jian‐Min , Wang Chih‐Yuan 
Published: October 2020

AbstractHyperkalemia is a common problem in patients with acute or chronic kidney disease. Cation exchange resins, such as calcium polystyrene sulfonate (Kalimate) or sodium polystyrene sulfonate (Kayexalate), are frequently administered orally or rectally to correct hyperkalemia. Kalimate/Kayexalate administration has been reported to induce gastrointestinal injury. We report two cases of colonic necrosis and bowel perforation following Kalimate adminstration. A review of past literature pertaining to Kalimate/Kayexalate‐associated complications was performed.
Building Leadership, Capacity, and Power to Advance Health Equity and Justice through Community‐Engaged Research in the Midwest
Authors: Woods‐Jaeger Briana , Daniel‐Ulloa Jason , Kleven Lauren , Bucklin Rebecca , Maldonado Adriana , Gilbert Paul A. , Parker Edith A. , Baquero Barbara 
Published: October 2020

AbstractThe Health Equity Advancement Lab (HEAL) at the University of Iowa College of Public Health began in 2012 to support students, researchers, and community members interested in tackling persistent health inequities through a community‐based participatory research (CBPR) approach. Using concepts from critical consciousness theory, we developed an approach to building students’, faculty members’, and community partners’ capacity to engage in CBPR to promote health equity that involved immersion in developing CBPR projects. Our paper describes the evolution of HEAL as a facilitating structure that provides a support network and engages diverse stakeholders in critical reflection as they participate in research to advance health equity, and resulting political efficacy and social action. We describe one HEAL‐affiliated research project that employs a CBPR approach and has a strong focus on providing transformative learning experiences for students, faculty, and community members. We highlight challenges, successes, and lessons learned in the application of critical consciousness as a framework that engages diverse academic and community partners seeking to promote health equity. We argue that critical consciousness is a relevant theoretical framework to promote transformative learning among students, faculty, and community partners to promote health equity research in diverse communities.
Not Just Doing Time: Distinct Typologies of Attitudes and Emotions among Juvenile Justice‐Involved Youth
Authors: Modecki Kathryn Lynn 
Published: October 2020

AbstractAdolescents’ views of the legal system, just world beliefs, and moral emotions are interrelated and form an important frame of reference, particularly for young people involved in the juvenile justice system. Yet past scholarship has generally treated these as independent indices of youths’ experience. This study took a person‐centered, latent profile approach to attitudes and beliefs among 136 male youth incarcerated within secure US juvenile facilities. Three heterogeneous profiles were found (negative attitudes/low emotion, moderate attitudes/mixed emotions, and positive attitudes/positive emotion) which were differentially associated with antisocial behavior. Youth who belonged to historically marginalized populations had significantly lower odds of belonging to a protective profile characterized by positive legal attitudes, just world beliefs, and emotions (positive attitudes/positive emotion). Findings highlight our gaps in understanding young people’s experiences with legal and judicial entities and illustrate significant heterogeneity in youth’s frame of reference within the juvenile justice system.
Teacher training as a means to sustained and multiplicative behavior change: An example using fuel‐efficient stoves
Authors: Kendall Corinne J. , Leeds Austin , Tinka John , Lukas Kristen E. , Folta Elizabeth 
Published: October 2020

AbstractChimpanzee conservation is dependent on addressing key threats such as habitat degradation, which is fueled by collection of firewood in Uganda′s Kibale National Park. To address this threat, sustained behavior change that reduces dependence on fuelwood is needed. One of the greatest challenges for conservation education programs and behavior change campaigns is to have long‐term and consistent effects on communities. Teacher trainings have potential to influence a large number of students over an extended period of time. In this study, we tested if teacher training on an activity designed to reduce community impact on the environment and thus reduce habitat encroachment in a critical chimpanzee habitat—construction of fuel‐efficient stoves (FES)—could lead to retained knowledge and attitude improvements for students as well as sustained behavioral change in communities around Kibale National Park up to 2 years after initial training on the topic. We consistently found improvements in student knowledge and attitude change between the beginning and end of the year for third‐ and sixth‐grade students in 11 program schools, but not in four control schools. In addition, the number of FES built by 120 teachers engaged in the program and their students continued to average over 150 stoves per year across 4 years. Our study suggests that teacher training can lead to sustained and multiplicative behavior change, which may mitigate threats to chimpanzees and other wildlife threatened by habitat encroachment in the park over time.
Integrating climate and landscape models to prioritize areas and conservation strategies for an endangered arboreal primate
Authors: Cabral Rezende Gabriela , Sobral‐Souza Thadeu , Culot Laurence 
Published: October 2020

AbstractSpecies distributions are influenced by both climate conditions and landscape structure. Here we propose an integrated analysis of climatic and landscape niche‐based models for a forest‐dependent primate, the endangered black lion tamarin (Leontopithecus chrysopygus). We applied both climate and landscape variables to predict the distribution of this tamarin and used this information to prioritize strategic areas more accurately. We anticipated that this approach would be beneficial for the selection of pertinent conservation strategies for this flagship species. First, we built climate and landscape niche‐based models separately, combining seven algorithms, to infer processes acting on the species distribution at different scales. Subsequently, we combined climate and landscape models using the EcoLand Analysis. Our results suggest that historic and current landscape fragmentation and modification had profoundly adverse effects on the distribution of the black lion tamarins. The models indicated just 2096 km2 (out of an original distribution of 92,239 km2) of suitable areas for both climate and landscape. Of this suitable area, the species is currently present in less than 40%, which represents less than 1% of its original distribution. Based on the combined map, we determined the western and southeast regions of the species range to be priority areas for its conservation. We identified areas with high climatic and high landscape suitability, which overlap with the remaining forest fragments in both regions, for habitat conservation and population management. We suggest that areas with high climatic but low landscape suitability should be prioritized for habitat management and restoration. Areas with high landscape suitability and low climatic suitability, such as the Paranapiacaba mountain range should be considered in light of projected climate change scenarios. Our case study illustrates that a combined approach of climatic and landscape niche‐based modeling can be useful for establishing focused conservation measures that may increase the likelihood of success.
Commentary: Challenges of evaluating the effectiveness of public awareness campaigns in Congo Republic
Authors: Cox Debby , Pintea Lilian , Poaty Patricia , Nsafou Achille , Sitou Alain , Turmo Fernando , VillaMarin Enrique , Atencia Rebeca 
Published: October 2020

AbstractConservation groups are always challenged with assigning limited resources to interventions they assume will have the most effective impact in addressing threats to their conservation targets. These decisions are often made based on experience and perceived outcomes, rather than evidence. In the past decade, multiple public awareness and proactive law enforcement activities have been initiated in the Congo Republic to address the illegal wildlife trade. This paper presents the challenges faced and lessons learned in shifting from experience to evidence‐based program evaluation related to the effectiveness of billboards in informing and inspiring local populations to support positive conservation behavior with regard to great apes.
Highly sensitive and repeatable DNA‐SERS detection system using silver nanowires‐glass fiber filter substrate
Authors: Woo Ayoung , Lim Kyongmook , Cho Baek Hwan , Jung Ho Sang , Lee Min‐Young 
Published: October 2020

AbstractThis paper describes a new simple DNA detection method based on surface‐enhanced Raman scattering (SERS) technology using a silver nanowire stacked‐glass fiber filter substrate. In this system, DNA‐intercalating dye (EVAGreen) and reference dye (ROX) are used together to improve the repeatability and reliability of the SERS signals. We found that the SERS signal of EVAGreen was reduced by intercalation into DNA amplicons of a polymerase chain reaction on the silver nanowire stacked‐glass fiber filter substrate, whereas that of ROX stayed constant. The DNA amplicons could be quantified by correcting the EVAGreen‐specific SERS signal intensity with the ROX‐specific SERS signal intensity. Multivariate analysis by partial least square methods was also successfully performed. And we further applied it to loop‐mediated isothermal amplification with potential use for on‐site diagnostics. The sensitivities of the DNA‐SERS detection showed about 100 times higher than those of conventional fluorescence‐based detection methods. The DNA‐SERS detection method can be applied to various isothermal amplification methods, which is expected to realize on‐site molecular diagnostics with high sensitivity, repeatability, simplicity, affordability, and convenience.