bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic Analysis Of Trichuris Trichiura Egg Extract Reveals Potential Immunomodulators And Diagnostic Targets
Authors: Cruz K. , Marcilla A. , Kelly P. , Vandenplas M. , Osuna A. , Trelis M. 
Published: July 2020

Abstract
Background: Trichuris trichiura embryonated eggs are the infectious developmental stage and the first signal to the immune system of the definitive host. Each infective T. trichiura egg carries the antigens needed to challenge the immune system with a wide variety of proteins present in the shell, larvae’s surface, and the accompanying fluid that contains their excretions/secretions. The parasite eggs constitute the first antigenic stimuli to evoke the host response to this intestinal parasite with direct life cycle and enteric development.Methods: The soluble egg extract of T. trichiura obtained from naturally infected African green monkeys (Chlorocebus sabaeus) was investigated using a proteomic approach by mass spectrometry. The antigenic profile of the egg soluble proteins against sera IgG from C. sabaeus with trichuriasis was also investigated by Western blot and LC-MS/MS from the corresponding SDS-PAGE gel.Results: A total of 231 proteins were accurately identified, 168 with known molecular functions. The proteome of the egg lysate revealed common protein families including energy and metabolism; cytoskeleton, motility and muscle; proteolysis; signaling; stress and detoxification; transcription and translation and; lipid binding and transport. Vitellogenin N and VWD and DUF1943 domain containing protein, Poly-cysteine and histidine tailed protein isoform 2, Heat shock protein 70, Glyceraldehyde-3-phosphate dehydrogenase, Actin and Enolase, were among the potential immunoactive proteins. Conclusions: To our knowledge, this study represents the first attempt to identify the proteome of the T. trichiura egg extract as a novel source of immunomodulators and targets for immunodiagnosis able to contribute to the treatment of human autoimmune diseases and to the control of this neglected disease.
Effects of Parents’ Value of Children on Adolescent Depression: A Cross-Sectional Study in China
Authors: Dong Dan , Feng Yi , Zheng Mengna , Zong Min , Zhang Peng , Qiao Zhihong 
Published: July 2020

Abstract
Background: Parenting style has been extensively demonstrated as a predictor of depression in children and adolescents, but few studies have examined the antecedents of parenting style, especially parents’ beliefs towards children. The effect of parents’ implicit beliefs on children’s mental health is still unclear. This study aimed to explore the influence of parents’ value of children (VOC) on adolescent depression, and the underlying mechanism between parents’ VOC and adolescent depression.Methods: High school and college students and their parents were recruited to participate a cross-sectional online survey. The parents completed the VOC scale, and the adolescents completed the scales of parenting style, external LOC, self-esteem, and depression. A structural equation model was performed to analyze the multiple mediating effects on adolescent depression.Results: A total of 963 Chinese adolescents (Mage = 17.78 ± 1.94 years, 55.5% female) and their parents (Mage = 45.40 ± 4.40 years, 58% mothers) were recruited and examined in the current analysis. The results showed that the social and psychological benefits of VOC directly predict adolescent depression (βsocial benefits = 0.191, p < 0.001; βpsychological benefits = - 0.180, p < 0.001), whereas the relational benefits of VOC do not (βrelational benefits = - 0.027, p > 0.05). Moreover, the underlying mechanism and paths were examined between VOC, parenting style, external locus of control, self-esteem and depression.Conclusions: Our results enrich the theoretical framework of parents’ VOC on adolescent depression. It also provides valuable practical insights into parenting attitudes and beliefs, and highlighted the importance of VOC towards psychological benefits as a possible protective factor against depression in adolescence.
The association between ambient temperature and mortality of the coronavirus disease 2019 (COVID-19) in Wuhan, China: A time-series analysis
Authors: Zhu Gaopei , Zhu Yuhang , Wang Zhongli , Meng Weijing , Wang Xiaoxuan , Feng Jianing , Li Juan , Xiao Yufei , Shi Fuyan , Wang Suzhen 
Published: July 2020

Abstract
BackgroundThe COVID-19 has caused a sizeable global outbreak and has been declared as a public health emergency of international concern. Sufficient evidence shows that temperature has an essential link with respiratory infectious diseases. The objectives of this study were to describe the exposure-response relationship between ambient temperature, including extreme temperatures, and mortality of COVID-19.MethodsThe Poisson distributed lag non-linear model (DLNM) was constructed to evaluate the non-linear delayed effects of ambient temperature on death, by using the daily new death of COVID-19 and ambient temperature data from January 10 to March 31, 2020, in Wuhan, China.ResultsDuring the period mentioned above, the average daily number of COVID-19 deaths was approximately 45.2. Poisson distributed lag non-linear model showed that there was a non-linear relationship (U-shape) between the effect of ambient temperature and mortality. With confounding factors controlled, the daily cumulative relative death risk decreased by 12.5 % (95 % CI [3.8 %, 20.4 %]) for every 1.0 °C increase in temperature. Moreover, the delayed effects of the low temperature are acute and short-term, with the most considerable risk occurring in 5–7 days of exposure. The delayed effects of the high temperature appeared quickly, then decrease rapidly, and increased sharply 15 days of exposure, mainly manifested as acute and long-term effects. Sensitivity analysis results demonstrated that the results were robust.ConclusionsThe relationship between ambient temperature and COVID-19 mortality was non-linear. There was a negative correlation between the cumulative relative risk of death and temperature. Additionally, exposure to high and low temperatures had divergent impacts on mortality.
USO DE TÉCNICAS VEGETATIVAS NA RECUPERAÇÃO DE SOLO DE TALUDE AS MARGENS DA RODOVIA BR 381 EM MINAS GERAIS
Authors: Vieira Alexandre sylvio , Neto Antonio pereira 
Published: July 2020

Os estudos de impactos ambientais em relação à construção das estradas, devem ser encarados avaliando-se a dimensão dos investimentos em função da região e dos efeitos negativos ao meio ambiente. Este trabalho foi realizado em um talude da estrada BR 381 na região Leste de Minas Gerais onde o solo foi caracterizado como Argissolo vermelho amarelo. Foram utilizados os tratamentos: Monocultivo da braquiaria, leucena, crotalária e guandu além dos cultivos da leucena, braquiaria, crotalaria e guandu consorciados. Foram construídos sulcos na horizontal com distância de 0,5 metro seguido de semeadura adensada. Após 18 meses de desenvolvimento das plantas, foram coletados amostras de solo para determinação de suas características de densidade aparente e capacidade de retenção de água nas linhas de plantio e entrelinhas. A presença das plantas beneficiou as características físicas do solo nas linhas de plantio como densidade aparente e retenção de água com exceção da cultura da leucena. A redução da capacidade de reter água dos solos foi observada nos solos adensados das entrelinhas, o mesmo não ocorrendo com os solos das linhas de plantio, local de desenvolvimento das raízes. Na linha de plantio do Guandu, os valores de retenção de água foram 23% superiores quando comparado a capacidade de retenção de água das entrelinhas de cultivo.
Deactivation of Ascaris suum eggs using electroporation and sequential inactivation with chemical disinfection
Authors: Niven C. , Parker C. B. , Wolter S. D. , Dryzer M. H. , Arena C. B. , Stoner B. R. , Ngaboyamahina E. 
Published: July 2020

Abstract
Electroporation has been evaluated as a potential backend wastewater treatment for deactivation of Ascaris suum eggs in buffer solution. Initial results indicate that eggshell permeability is affected by the pulse train electric field strength and duration. Coupling electroporation with chemical exposure, using low concentrations of commercially available disinfectants, allows oxidizing agents to pass through the complex strata of the A. suum eggshell, specifically reaching the innermost embryonic environment, which leads to successful deactivation compared to either method used separately. The aim of this work is to identify and develop an alternative technique that efficiently inactivates helminth eggs present in wastewater.
Parameter estimation of a dual-pol radar rain rate estimator with truncated paired data
Authors: Ku Jung Mo , Na Wooyoung , Yoo Chulsang 
Published: July 2020

Abstract
This study proposes a new method for estimating the parameters of a radar rain rate estimator, particularly of the dual-pol radar. The proposed method is similar to the probability matching method (PMM), except for being based on truncated data pairs. A truncation value is introduced to the log-transformed data in order to remove those in the low rain rate zone as well as to introduce Gaussian distribution. The parameters are then estimated by comparing the first- and second-order moments. The proposed method is applied to a total of six rainfall events observed by the Beaslesan Radar in Korea from 2014 to 2017. Summarizing the results, first, the truncation value should be applied to the horizontal reflectivity (dBZh) data. In this case only, the other two data, the rain rate (dBR) and the differential reflectivity (dBZdr), follow the Gaussian distribution well. It is also important to consider rather severe rainfall events for the parameter estimation. The parameters for only the severe rainfall events are all estimated rather reasonably. On the other hand, for the other moderate and light rainfall events, the parameters are estimated as being rather far from their normal ranges. This is mainly due to the relatively small variance of dBR compared to that of dBZh. That is, the variance of dBR is found to be greatly dependent on the peak rain rate, but the variance of dBZh remains almost unchanged, regardless of the peak rain rate. As a result, the peak rain rate plays a dominant role in the reasonable parameter estimation. These findings are also consistent with many previous studies.
The Development of Spectrophotometric and Validated Stability- Indicating RP-HPLC Methods for Simultaneous Determination of Ephedrine HCL, Naphazoline HCL, Antazoline HCL, and Chlorobutanol in Pharmaceutical Pomade Form
Authors: Dindar Çiğdem K. , Erkmen Cem , Uslu Bengi , Göğer Nilgün G. 
Published: July 2020

Background:
Allergic rhinitis, acute nasal congestion and sinusitis are one of the most
common health problems and have a major effect on the quality of life. Several medications are
used to improve the symptoms of such diseases in humans. Pharmaceutical pomade form
containing Ephedrine (EPD) HCl, Naphazoline (NPZ) HCl, Antazoline (ANT) HCl, and
Chlorobutanol (CLO) is one of them.

Objective:
For these reasons, this study includes the development of spectrophotometric and
chromatographic methods for the determination of EPD HCl, NPZ HCl, ANT HCl, and CLO
active agents in the pharmaceutical pomade.

Method:
In the spectrophotometric method, third-order derivative of the amplitudes at 218 nm n=5
and the first-order derivative of the amplitudes 254 nm n=13 was selected for the determination of
EPD, ANT, respectively while NPZ was determined by the second derivative at 234 nm and n=21.
Colorimetric detection was applied for assay analysis of CLO at 540 nm. Furthermore, a reverse
phase high performance liquid chromatographic (RP- HPLC) method has been developed and
optimized by using Agilent Zorbax Eclipse XDB C18 (75 mm x 3.0 mm, 3.5μm) column. The
column temperature was 40°C, binary gradient elution was used and the mobile phase consisted of
15 mM phosphate buffer in distilled water (pH 3.0) and methanol, and the flow rate was 0.6 mL
min-1 and the UV detector was detected at 210 nm. The linear operating range was obtained as
11.97-70, 0.59-3, 2.79-30, and 2.92-200 μg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO
respectively.

Results:
The LOD values were found to be 3.95, 0.19, 0.92 and 0.96 μg mL-1 for EPD HCl, NPZ
HCl, ANT HCl, and CLO in the spectrophotometric method, respectively. The linear ranges in the
RP-HPLC method were 8.2-24.36 μg mL-1, 0.083 - 0.75 μg/mL, 2.01-7.5 μg mL-1 and 2.89-24.4
μg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO, respectively. The LOD values in the
validation studies were 2.7, 0.025, 0.66 and 0.86 μg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and
CLO in RP-HPLC method respectively.

Conclusion:
The results of the spectrophotometric and chromatographic methods were compared
and no differences were found between the two methods.
Patient Satisfaction with the Etanercept Biosimilar SB4 Device, Among Rheumatoid Arthritis and Spondyloarthropathy Patients - A German Observational Study
Authors: Maucksch Christof , Aries Peer M. , Zinke Silke , Müller-Ladner Ulf 
Published: July 2020

Background:
The etanercept biosimilar SB4 is a TNF inhibitor authorised for use as a targeted Biological Disease-Modifying Anti-Rheumatic Drug (bDMARD). Various administration devices have been developed for subcutaneous self-injection of bDMARDs.

Objective:
This study surveyed patient satisfaction with their experience of using the SB4 pre-filled pen device.

Methods:
This non-interventional, cross-sectional, multi-centre study enrolled adult rheumatoid arthritis and spondyloarthropathy patients who had been treated for at least three months with the SB4 pre-filled pen. Based on a standardized questionnaire, patients rated general satisfaction, handling, user-friendliness, physical characteristics, and training material received. A total of 492 eligible patients completed questionnaires at 43 centres across Germany between August 2017 and June 2018. Data were analysed descriptively. Pre-defined subgroup analyses by previous therapy and by indication were performed.

Results:
Overall, 87% (95% CI 83% - 90%) of patients reported being ‘satisfied’ or ‘very satisfied’ with the pen. 89% of patients reported that the pen was ‘simple’ or ‘very simple’ to use. Most patients (87%) self-injected. 93% of patients who received training on the use of the pen were ‘satisfied’ or ‘very satisfied’ with the training provided. In this cross-sectional study, 12 patients reported an Adverse Event (AE) and one patient reported a treatment-related AE (nausea).

Conclusion:
The results demonstrated a high level of general satisfaction among patients using the SB4 pre-filled pen as well as satisfaction with ease of use for patients who were either naïve to bDMARDs or who had switched to SB4 from other bDMARDs.
Theoretical Foundations of Adolescent Development through Tagiuri’s Taxonomy: Analysis of Educational Setting as an Organizational Climate
Authors: Aslan Mehmet , Kosir Suzana , Levidze Marine 
Published: July 2020

Background:Research on student attachment and adolescent development indicates that negligence or lack of support during development processes such as social, emotional, and psychological processes could cause severe harm to their future lives in adulthood. Thus, delinquent behaviors may occur as less severe in peer pressure, academic challenges, family problems and as more severe in truancy, drop-out, academic failure, substance usage, juvenile crimes, suicidal tendencies,etc.Aims:In this regard, the present study aims at providing theoretical foundations of adolescent development through Tagiuri’s four scaled taxonomy in order to analyze the school environment as an organizational climate: ecology, milieu, social system, and culture.Methods:Based on the presented literature review, content analysis was used to present different theoretical foundations of adolescents based on Taqiuri’s four scaled taxonomy on school attachment. The content analysis helped us to analyze the presence, meaning and relationship of certain themes or concept.Results:The study shows that one of the significant challenges that appear for educational settings is to find ways and strategies to address students` developmental and academic needs in a fashion of preventing delinquent behaviors and fostering adaptive behaviors. One of the major findings of the study suggests that educational performance and enhancement should be measured together with the four scaled taxonomy to reach a complete framework of a bonding model in education.Conclusion:The study also aims at providing an overview of the research on Attachment Theory and its relation with Tagiuri’s four scaled taxonomy by analysis of a comprehensive research table in the field.
RELAÇÃO DE CAUSALIDADE ENTRE A FEBRE DA ZIKA E MICROCEFALIA NO BRASIL: REVISÃO INTEGRATIVA
Authors: Mercês André Emanuel Dantas , Cajuhi Angela de Souza , Santos Lorena Conceição Souza dos , Silva Rudval Souza da , Suto Cleuma Sueli Santos , Oliveira Jones Sidnei Barbosa de 
Published: July 2020

O Zika vírus é um arbovírus transmitido pela picada dos mosquitos Aedes aegypti e Aedes albopictus infectados e apresentam como principais manifestações clínicas: febre aguda, exantema, prurido e conjuntivite. Em 2015 causou uma epidemia no Brasil, desencadeando casos de microcefalia em bebês cujas gestantes tiveram a febre da Zika. O Nordeste notificou o maior número de casos. Objetivou-se identificar, a partir de uma revisão integrativa, a relação entre a febre da Zika e a microcefalia. Trata-se de revisão integrativa, realizada a partir de buscas desenvolvidas nas bases de dados da Biblioteca Virtual em Saúde (BVS) e da Scientific Electronic Library Online (SciELO) com publicações dos anos de 2015 e 2016, idiomas português e inglês. Foram encontradas 191 publicações, as quais passaram por um processo de leitura e análise quanto ao atendimento do objetivo e aplicação dos critérios de inclusão. Restaram oito publicações que integraram o corpus desta revisão. Os resultados apontam para uma relação de causa e efeito entre o contato das gestantes com o Zika vírus e o desenvolvimento de microcefalia em seus bebês. Necessita-se de maiores evidências que demonstrem os reais fatores envolvidos nesse processo, como os genéticos, ambientais e até mesmo interferência de outras infecções.
Palavras-chave: Zika vírus. Microcefalia. Aplicações da epidemiologia.
QUALIDADE BACTERIOLÓGICA E PARASITOLÓGICA DE MÃOS E CONDIÇÕES DE SAÚDE E HIGIENE EM HORTICULTORES
Authors: Silva Juciene de Jesus Barreto da , Miranda Felipe Silva de , Oliveira Juliana Mercês de Oliveira e , Amor Ana Lúcia Moreno , Silva Isabella de Matos Mendes da 
Published: July 2020

A produção é uma das principais etapas envolvidas na contaminação das hortaliças. Entre os fatores que contribuem para a contaminação está a falta de higiene e más condições de saúde dos produtores. Assim, o objetivo deste estudo foi investigar a ocorrência de bactérias e parasitos em mãos e as condições de saúde e higiene de horticultores em comunidades rurais do município de Santo Antônio de Jesus, Bahia. O período de coleta foi de agosto a outubro de 2015. Utilizou-se um questionário com dados pessoais e dados socioeconômicos e coleta de material fecal e subungueal. Realizaram-se análises parasitológicas do material fecal e subungueal e análises bacteriológicas do material subungueal. A análise estatística foi baseada no teste qui-quadrado de Pearson. O nível de significância adotado foi de 5% (p < 0,05). Foram entrevistados 21 horticultores, dos quais 62% eram do sexo masculino e 38% do sexo feminino. A faixa etária prevalente variou de 20 a maior que 50 anos (86%). Constatou-se que 17 (77%) dos horticultores estavam parasitados por helmintos ou protozoários. Em relação aos resultados bacteriológicos, apenas um horticultor (4,7%) apresentou valores de 2 log UFC/mão para coliformes totais e 18 (85,8%) para S. aureus. É de extrema importância que os horticultores tenham bons hábitos higiênicos, a fim de garantir a qualidade dos alimentos e proporcionar segurança alimentar aos consumidores. Sugere-se a implementação de programas de formação em higiene pessoal e manipulação segura para os horticultores e acompanhamento anual dos índices parasitários pelos órgãos oficiais contribuindo para o aprimoramento da educação sanitária destes profissionais.
Palavras-chave: Educação sanitária. Agricultura. Segurança alimentar.
Penentuan Tingkat Kebisingan Pada Area Pengolahan Sekam Padi, Siltstone Crusher, Cooler Dan Power Plant Pada PT Lafarge Cement Indonesia-Lhoknga Plant
Authors: Harahap Juliansyah 
Published: July 2020

This research conducted in PT. Lafarge Cement Indonesia which is one of company whose field in cement production located in western Indonesia region, exact place in Aceh province. The aimed of this research are to know about noise levels in some production areas of PT. Lafarge Cement Indonesia Lhoknga plant and define anticipation actions to the effect of existing noice level based on Hierarchy of Control (HoC). Used method in this research are measuring method with sampling points where measurement conducted if the noise suspected over the threshold limit by conducting noise sampling just onto one or few locations. Sample data obtained then being processed and analized by using statistical method.
The result of this research concluded that rice husk processing area, siltstone crusher, cooler and most of power plant area which is in front of condenser 1 and 2, and near to turbin 1 and 2 have LAeq value over than 85 dB so that using hearing protection is a mandatory. Control conduct to
the over noise shelf in few areas can be conducted by implementing HoC
like elimination, substitution, engineering control (redesigning equipment,
servicing and maintaining equipment, isolating equipment, damping and cushioning noise source and installing absorbtive baffles), administrative control (work hours per day limitation and health surveillance program)
and using tools for self protection (application of hearing protection with NRR which can cover the noise shelf to workers).
HUBUNGAN BUDAYA ORGANISASI DENGAN KINERJA PEGAWAI DINAS PENDIDIKAN PEMUDA DAN OLAHRAGA KOTA SAWAHLUNTO
Authors: MAN WIDIA ANINGSIH 
Published: July 2020

This research aimed to describe the employee performance, organizational culture and cultural relations organization with the performance satisfaction at Dinas Pendidikan Pemuda dan Olahraga Kota Sawahlunto. The hypothesis of the proposed research is “organizational culture is significantly correlated with the performance of employee at Dinas Pendidikan Pemuda dan Olahraga Kota Sawahlunto”. The present research is correlational which to see organizational culture with employee performance at Dinas Pendidikan Pemuda dan Olahraga Kota Sawahlunto. The population is 69 people and samples is 61 people. Large instrument used for data collection was a questionnaire type a Likert scale that have been valid and reliabel. The techhique of data analysis is done by using the formula Product Moment Correlation and T-test. The result of the dataanalysis showed that (1) employee performance at Dinas Pendidikan Pemuda dan Olahraga Kota Sawahlunto is in the category is good (85,15%), (2) organizational culture are on the category good (89,54%), and (3) there is a significant organizational culture between leadership with employee performance with a correlation coefficient = 0,327. So it can be concluded tha organizational culture affects employee performance at Dinas Pendidikan Pemuda dan Olahraga Kota Sawahlunto.