bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomical-based percutaneous left stellate ganglion block in patients with drug-refractory electrical storm and structural heart disease: a single-centre case series
Authors: Savastano Simone , Dusi Veronica , Baldi Enrico , Rordorf Roberto , Sanzo Antonio , Camporotondo Rita , Fracchia Rosa , Compagnoni Sara , Frigerio Laura , Oltrona Visconti Luigi , De Ferrari Gaetano Maria 
Published: September 2020

Abstract

Aims
The adoption of percutaneous stellate ganglion blockade for the treatment of drug-refractory electrical storm (ES) has been increasingly reported; however, the time of onset of the anti-arrhythmic effects, the safety of a purely anatomical approach in conscious patients and the additional benefit of repeated procedures remain unclear.

Methods and results
This study included consecutive patients undergoing percutaneous left stellate ganglion blockade (PLSGB) in our centre for drug-refractory ES. Lidocaine, bupivacaine, or a combination of both were injected in the vicinity of the left stellate ganglion. Overall, 18 PLSGBs were performed in 11 patients (age 69 ± 13 years; 63.6% men, left ventricular ejection fraction 31.6 ± 16%). Seven patients received only one PLSGB; three underwent two procedures and one required three PLSGB and two continuous infusions to control ventricular arrhythmias (VAs). All PLSGBs were performed with an anatomical approach; lidocaine, alone, or in combination was used in 77.7% of the procedures. The median burden of VAs 1 h after each block was zero compared with five in the hour before (P &lt; 0.001); 83% of the patients were free from VAs; the efficacy at 24 h increased with repeated blocks. The anti-arrhythmic efficacy of PLSGB was not related to anisocoria. No procedure-related complications were reported.

Conclusion
Anatomical-based PLSGB is a safe and rapidly effective treatment for refractory ES; repeated blocks provide additional benefits. Percutaneous left stellate ganglion blockade should be considered for stabilizing patients to allow further ES management.
Breeding selection imposed a differential selective pressure on the wheat root-associated microbiome
Authors: Kinnunen-Grubb Marta , Sapkota Rumakanta , Vignola Marta , Nunes Inês Marques , Nicolaisen Mogens 
Published: September 2020

ABSTRACTPlants-microbiome associations are the result of millions of years of co-evolution. Due to breeding-accelerated plant evolution in non-native and highly managed soil, plant-microbe links could have been lost. We hypothesized that post-domestication breeding of wheat changed the root-associated microbiome. To test this, we analyzed root-associated fungal and bacterial communities shortly after emergence of seedlings representing a transect of wheat evolution including modern wheat, landraces and ancestors. Numbers of observed microbial taxa were highest in landraces bred in low-input agricultural systems, and lowest in ancestors that had evolved in native soils. The microbial communities of modern cultivars were different from those of landraces and ancestors. Old wheat accessions enriched Acidobacteria and Actinobacteria, while modern cultivars enriched OTUs from Candidatus Saccharibacteria, Verrucomicrobia and Firmicutes. The fungal pathogens Fusarium, Neoascochyta and Microdochium enriched in modern cultivars. Both bacterial and fungal communities followed a neutral assembly model when bulk soil was considered as the source community, but accessions of the ancient Triticum turgidum and T. monococcum created a more isolated environment in their roots. In conclusion, wheat root-associated microbiomes have dramatically changed through a transect of breeding history.
Network Modeling of Assisted Living Facility Residents’ Attendance at Programmed Group Activities: Proximity and Social Contextual Correlates of Attendance
Authors: Mauldin Rebecca L , Wong Carin , Fernandez Jason , Fujimoto Kayo 
Published: September 2020

Abstract

Background and Objectives
Social engagement, including participation in group activities, supports older adults’ mental and physical health. However, many residents of assisted living facilities do not participate in their facility’s programmed group activities. Explaining residents’ attendance at group activities is complex; attendance is associated with a confluence of individual-level and contextual factors. The aim of this study was to assess the effects of multilevel factors on attendance, including residents’ proximity to activity location and the potential for one resident’s attendance to depend on other residents’ attendance.

Research Design and Methods
We used bipartite exponential random graph models to examine the attendance of 35 residents at 563 programmed group activities. We simultaneously modeled the effects of the geospatial distance from a resident’s apartment to the activity and the tendency for residents to attend activities with similar groups of other residents (i.e., shared attendance) on the likelihood of attendance, while controlling for individual-level factors (demographic and health indicators) and activity popularity.

Results
Greater distance was associated with a reduced likelihood of attendance (p &lt; .001) and residents tended to attend activities with similar subsets of other residents (p &lt; .001).

Discussion and Implications
Findings suggest that greater distance to group activities may be a barrier to attendance. Implications include facility design, placement of activities and apartments, and mobility-related strategies to increase activity participation. It is also important to recognize that participation in activities is dependent on social context. We recommend that proximity to activities and social contextual factors be considered in future examinations of attendance at group activities.
Construction of a chromosome-scale long-read reference genome assembly for potato
Authors: Pham Gina M , Hamilton John P , Wood Joshua C , Burke Joseph T , Zhao Hainan , Vaillancourt Brieanne , Ou Shujun , Jiang Jiming , Buell C Robin 
Published: September 2020

Abstract

Background
Worldwide, the cultivated potato, Solanum tuberosum L., is the No. 1 vegetable crop and a critical food security crop. The genome sequence of DM1–3 516 R44, a doubled monoploid clone of S. tuberosum Group Phureja, was published in 2011 using a whole-genome shotgun sequencing approach with short-read sequence data. Current advanced sequencing technologies now permit generation of near-complete, high-quality chromosome-scale genome assemblies at minimal cost.

Findings
Here, we present an updated version of the DM1–3 516 R44 genome sequence (v6.1) using Oxford Nanopore Technologies long reads coupled with proximity-by-ligation scaffolding (Hi-C), yielding a chromosome-scale assembly. The new (v6.1) assembly represents 741.6 Mb of sequence (87.8%) of the estimated 844 Mb genome, of which 741.5 Mb is non-gapped with 731.2 Mb anchored to the 12 chromosomes. Use of Oxford Nanopore Technologies full-length complementary DNA sequencing enabled annotation of 32,917 high-confidence protein-coding genes encoding 44,851 gene models that had a significantly improved representation of conserved orthologs compared with the previous annotation. The new assembly has improved contiguity with a 595-fold increase in N50 contig size, 99% reduction in the number of contigs, a 44-fold increase in N50 scaffold size, and an LTR Assembly Index score of 13.56, placing it in the category of reference genome quality. The improved assembly also permitted annotation of the centromeres via alignment to sequencing reads derived from CENH3 nucleosomes.

Conclusions
Access to advanced sequencing technologies and improved software permitted generation of a high-quality, long-read, chromosome-scale assembly and improved annotation dataset for the reference genotype of potato that will facilitate research aimed at improving agronomic traits and understanding genome evolution.
Time-lapse CSEM: how important is survey repeatability?
Authors: Shantsev Daniil V , Nerland Elias A , Gelius Leiv-J 
Published: September 2020

SUMMARYAn important concern for time-lapse studies using the controlled-source electromagnetic (CSEM) method is repeatability of acquisition parameters for the base and monitoring surveys. We consider a challenging case when variations in source and receiver positions, conductivity of seawater, etc. will lead to differences in the recorded EM fields that exceed EM response due to production-induced changes in the reservoir resistivity. We show that even in that case, 4-D response can often be clearly resolved if the base and monitor EM data sets are inverted to produce 3-D resistivity distributions. More precisely, for a synthetic model of the Snøhvit gas field, changes in the inverted resistivity maps caused by such non-repeatability will be at least 10 times smaller than the time-lapse differences in the reservoir resistivity. By contrast, measurement errors and poor knowledge of background resistivity may reduce the resolution of 4-D CSEM to a much stronger degree. Analysis of field CSEM data from the Wisting oil field supports our conclusion about strongly relaxed repeatability requirements when 4-D effects are established by examining inverted resistivity volumes rather than by looking at raw EM data.
Application of the theory of planned behavior to predict smoking intentions: cross-cultural comparison of Kenyan and American young adults
Authors: Lu Yu , Shin YoungJu , Gitau Mary W , Njoroge Margaret W , Gitau Peter , Temple Jeff R 
Published: September 2020

Abstract
Despite well-established research on the applications of the theory of planned behavior (TPB) in the American culture, TPB has not been fully tested in the Kenyan culture. This study compared the applications of TPB in predicting smoking intentions (i.e., future and weekend smoking intentions) of Kenyan and American young adults. Data were collected from 252 Kenyans and 227 Americans. The Kenyan participants consisted of 41.7% females with a mean age of 25 years (SD = 4.81). The American participants (49.3% females) had an average age of 19 years (SD = 1.30). Multi-group path analysis was performed to test the equivalence of a TPB-based mediation model in Kenyans and Americans. Significant differences of TPB application were detected. In the American model, smoking consequence beliefs were indirectly associated with smoking intentions through attitudes whereas neither direct nor indirect effects of smoking consequence beliefs were detected in the Kenyan model. Instead, normative beliefs indirectly associated with future and weekend smoking intentions through attitudes and subjective norms in the Kenyan model. Despite some overlapping paths, there were cultural variations on specific associations among TPB constructs between Kenyans and Americans. Cultural adaptations may be needed when applying TPB in the Kenyan cultural context.
Safety of Ustekinumab in Inflammatory Bowel Disease: Pooled Safety Analysis of Results from Phase 2/3 Studies
Authors: Sandborn William J , Feagan Brian G , Danese Silvio , O’Brien Christopher D , Ott Elyssa , Marano Colleen , Baker Thomas , Zhou Yiying , Volger Sheri , Tikhonov Ilia , Gasink Christopher , Sands Bruce E , Ghosh Subrata 
Published: September 2020

Abstract

Background
Ustekinumab is currently approved globally in Crohn’s disease (CD) and psoriatic diseases. Recent phase 3 data demonstrate safety/efficacy in ulcerative colitis (UC). Crohn’s disease and UC phase 3 programs had similar study designs, facilitating integrated safety analyses.

Methods
Data from 6 ustekinumab phase 2/3 CD and UC studies were pooled, and safety was evaluated through 1 year. Patients received 1 placebo or ustekinumab (generally 130 mg or ~6 mg/kg) intravenous induction, then subcutaneous (90 mg) maintenance every 8/12 weeks. Analyses incorporated all patients who received ≥1 ustekinumab dose. Safety outcomes are presented as percentages of patients (induction) and as number of patients with events per 100 patient-years of follow-up (through 1 year). For key safety events, 95% confidence intervals (CIs) are provided, as appropriate. Hazard ratios with 95% CIs from time-to-event analyses for serious adverse events and serious infections were also performed.

Results
Through 1 year, 2574 patients received ustekinumab (1733 patient-years of follow-up). The number of patients with adverse events per 100 patient-years (placebo 165.99 [95% CI, 155.81–176.67] vs ustekinumab 118.32 [95% CI, 113.25–123.55]), serious AEs (27.50 [95% CI, 23.45–32.04] vs 21.23 [95% CI, 19.12–23.51]), infections (80.31 [95% CI, 73.28–87.84] vs 64.32 [95% CI, 60.60–68.21]), serious infections (5.53 [95% CI, 3.81–7.77] vs 5.02 [95% CI, 4.02–6.19]), and malignancies excluding nonmelanoma skin cancer (0.17 [95% CI, 0.00–0.93] vs 0.40 [95% CI, 0.16–0.83]) were similar between placebo and ustekinumab.

Conclusions
The safety profile of ustekinumab across the pooled inflammatory bowel disease population through 1 year was favorable and generally comparable to placebo. These data are consistent with the established safety profile of ustekinumab across indications.

ClinicalTrials.gov numbers
NCT00265122; NCT00771667; NCT01369329; NCT01369342; NCT01369355; NCT02407236.
Current understandings of the relationship between extracellular vesicles and cilia
Authors: Ikegami Koji , Ijaz Faryal 
Published: September 2020

Abstract
Mammalian cells have a tiny hair-like protrusion on their surface called a primary cilium. Primary cilia are thought to be the antennae for the cells, receiving signals from the environment. In some studies, extracellular vesicles (EVs) were found attached to the surface of the primary cilium. An idea for the phenomenon is that the primary cilium is the receptor for receiving the EVs. Meanwhile, a unicellular organism, Chlamydomonas, which has two long cilia, usually called flagella, release EVs termed ectosomes from the surface of the flagella. Accumulating evidence suggests that the primary cilium also functions as the ‘emitter’ of EVs. Physiological and pathological impacts are also elucidated for the release of EVs from primary cilia. However, the roles of released cilia-derived EVs remain to be clarified. This review introduces the historical background of the relationship between EVs and cilia, and recent progresses in the research field.
Management of Pear Psylla (Hemiptera: Psyllidae) Using Reflective Plastic Mulch
Authors: Nottingham Louis B , Beers Elizabeth H 
Published: September 2020

AbstractPear psylla, Cacopsylla pyricola (Förster), has remained the most challenging pest of commercial pears in Washington and Oregon, the top producers of pears in the United States. The lack of effective integrated pest management tactics for this pest has been a major barrier to effective management. In this study, we examined the potential for reflective plastic mulch affixed beneath pear trees to suppress pear psylla. In 2017 and 2018, single pear tree (cv. Bartlett) plots of reflective plastic mulch, black plastic mulch, and no mulch (check) were established in a research orchard to compare their effects on pear psylla. Arthropods were sampled every 7–14 d from March through late summer. In both years, reflective mulch plots had significantly fewer pear psylla adults, eggs, and nymphs of the first generation compared with black plastic and check plots. However, later generations of psylla were not suppressed by reflective mulch. Semi-field tests were conducted in 2019 and 2020 using uniformly pruned potted pear trees on either reflective plastic mulch or grass to determine whether summerform adults were tolerant to reflected light from mulch, or if shading from vegetative growth negated the effect of the mulch. In both years, significantly fewer summerform adults and eggs were found in reflective mulch plots, suggesting that shading, rather than summerform tolerance, reduced effects from reflective mulch in the summer. This study demonstrates the potential for reflective mulch to suppress pear psylla and justifies future examination as part of a season-long management program.
Complexity of finite-variable fragments of products withK
Authors: Rybakov Mikhail , Shkatov Dmitry 
Published: September 2020

AbstractWe show that products and expanding relativized products of propositional modal logics where one component is the minimal monomodal logic K are polynomial-time reducible to their single-variable fragments. Therefore, the known lower-bound complexity and undecidability results for such logics are extended to their single-variable fragments. Similar results are obtained for products where one component is a polymodal logic with a K-style modality; these include products with propositional dynamic logics.
The impact of episodic outflow feedback on stellar multiplicity and the star formation efficiency
Authors: Rohde P F , Walch S , Clarke S D , Seifried D , Whitworth A P , Klepitko A 
Published: September 2020

ABSTRACT
The accretion of material on to young protostars is accompanied by the launching of outflows. Observations show that accretion, and therefore also outflows, are episodic. However, the effects of episodic outflow feedback on the core scale are not well understood. We have performed 88 smoothed particle hydrodynamic simulations of turbulent dense $1 \, {{\mathrm{M}}}_{\odot }$ cores to study the influence of episodic outflow feedback on the stellar multiplicity and the star formation efficiency (SFE). Protostars are represented by sink particles, which use a subgrid model to capture stellar evolution, inner-disc evolution, episodic accretion, and the launching of outflows. By comparing simulations with and without episodic outflow feedback, we show that simulations with outflow feedback reproduce the binary statistics of young stellar populations, including the relative proportions of singles, binaries, triples, etc. and the high incidence of twin binaries with q ≥ 0.95; simulations without outflow feedback do not. Entrainment factors (the ratio between total outflowing mass and initially ejected mass) are typically ∼7 ± 2, but can be much higher if the total mass of stars formed in a core is low and/or outflow episodes are infrequent. By decreasing both the mean mass of the stars formed and the number of stars formed, outflow feedback reduces the SFE by about a factor of 2 (as compared with simulations that do not include outflow feedback).
Planet migration, resonant locking, and accretion streams in PDS 70: comparing models and data
Authors: Toci Claudia , Lodato Giuseppe , Christiaens Valentin , Fedele Davide , Pinte Christophe , Price Daniel J , Testi Leonardo 
Published: September 2020

ABSTRACTThe disc surrounding PDS 70, with two directly imaged embedded giant planets, is an ideal laboratory to study planet–disc interaction. We present 3D smoothed particle hydrodynamics simulations of the system. In our simulations, planets, which are free to migrate and accrete mass, end up in a locked resonant configuration that is dynamically stable. We show that features observed at infrared (scattered light) and millimetre (thermal continuum) wavelengths are naturally explained by the accretion stream on to the outer planet, without requiring a circumplanetary disc around Planet c. We post-processed our near-infrared synthetic images in order to account for observational biases known to affect high-contrast images. Our successful reproduction of the observations indicates that planet–disc dynamical interactions alone are sufficient to explain the observations of PDS 70.
Supernovae and their host galaxies – VII. The diversity of Type Ia supernova progenitors
Authors: Hakobyan A A , Barkhudaryan L V , Karapetyan A G , Gevorgyan M H , Mamon G A , Kunth D , Adibekyan V , Turatto M 
Published: September 2020

ABSTRACT
We present an analysis of the light curve (LC) decline rates (Δm15) of 407 normal and peculiar supernovae (SNe) Ia and global parameters of their host galaxies. As previously known, there is a significant correlation between the Δm15 of normal SNe Ia and global ages (morphologies, colours, and masses) of their hosts. On average, those normal SNe Ia that are in galaxies from the Red Sequence (early-type, massive, old hosts) have faster declining LCs in comparison with those from the Blue Cloud (late-type, less massive, younger hosts) of the colour–mass diagram. The observed correlations between the Δm15 of normal SNe Ia and hosts’ parameters appear to be due to the superposition of at least two distinct populations of faster and slower declining normal SNe Ia from older and younger stellar components. We show, for the first time, that the Δm15 of 91bg- and 91T-like SNe is independent of host morphology and colour. The distribution of hosts on the colour–mass diagram confirms the known tendency for 91bg-like SNe to occur in globally red/old galaxies, while 91T-like events prefer blue/younger hosts. On average, the youngest global ages of 02cx-like SNe hosts and their positions in the colour–mass diagram hint that these events likely originate from young population, but they differ from 91T-like events in the LC decline rate. Finally, we discuss the possible explosion channels and present our favoured SN Ia models that have the potential to explain the observed SN–host relations.
Encounters involving planetary systems in birth environments: the significant role of binaries
Authors: Li Daohai , Mustill Alexander J , Davies Melvyn B 
Published: September 2020

ABSTRACT
Most stars form in a clustered environment. Both single and binary stars will sometimes encounter planetary systems in such crowded environments. Encounter rates for binaries may be larger than for single stars, even for binary fractions as low as 10–20 per cent. In this work, we investigate scatterings between a Sun–Jupiter pair and both binary and single stars as in young clusters. We first perform a set of simulations of encounters involving wide ranges of binaries and single stars, finding that wider binaries have larger cross-sections for the planet’s ejection. Secondly, we consider such scatterings in a realistic population, drawing parameters for the binaries and single stars from the observed population. The scattering outcomes are diverse, including ejection, capture/exchange, and collision. The binaries are more effective than single stars by a factor of several or more in causing the planet’s ejection and collision. Hence, in a cluster, as long as the binary fraction is larger than about 10 per cent, the binaries will dominate the scatterings in terms of these two outcomes. For an open cluster of a stellar density 50 pc−3, a lifetime 100 Myr, and a binary fraction 0.5, we estimate that Jupiters of the order of 1 per cent are ejected, 0.1 per cent collide with a star, 0.1 per cent change ownership, and 10 per cent of the Sun–Jupiter pairs acquire a stellar companion during scatterings. These companions are typically thousands of au distant and in half of the cases (so 5 per cent of all Sun–Jupiter pairs), they can excite the planet’s orbit through Kozai–Lidov mechanism before being stripped by later encounters. Our result suggests that the Solar system may have once had a companion in its birth cluster.