bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Results after Autologous Matrix-Induced Chondrogenesis for Osteochondral Lesions of the Talus: A 10-Year Cohort Study
Authors: Deiss Lukas , Walther Markus , Pfahl Kathrin , Hörterer Hubert , Mehlhorn Alexander , Röser Anke , Gottschalk Oliver 
Published: December 2024

Objective A gold standard surgical treatment for osteochondral lesions (OCLs) of the talus still needs to be established. Still, autologous matrix-induced chondrogenesis (AMIC) is a commonly applied 1-stage procedure that has achieved good short- and mid-term results. The present cohort study aimed to assess whether the long-term, 10-year results can confirm the previous findings. Design All patients underwent an open AMIC procedure using a collagen type I/III bilayer matrix for a talar OCL. General demographic data, preoperative magnetic resonance imaging findings, intraoperative details, and German version of the Foot Function Index (FFI-D) scores preoperatively and at 1, 5, and 10 years as well as European Foot and Ankle Society (EFAS) and American Orthopedic Foot & Ankle Society (AOFAS) scores at 10 years after surgery were analyzed. The primary outcome variable was the procedure’s longitudinal effect, and several variables’ influence on the outcome was tested. Results Of 47 consecutive patients, 18 (38%) were included. Of the 18 patients, 6 (33%) were female, and 12 (67%) were male, with a mean age of 39 ± 15 (range = 15-62) and an average body mass index (BMI) of 26 ± 5 (range = 20-38) kg/m². The mean defect size was 1.4 ± 0.9 (range = 0.2-4) cm². The FFI-D total score showed a significant decrease from preoperatively to 1 year postoperatively (56 ± 19 to 34 ± 27; P = 0.001) with a further nonsignificant decrease to the 5-year (34 ± 27 to 21 ± 20; P = 0.16) and 10-year follow-up (21 ± 20 to 15 ± 13; P = 1.00). All the single items decreased significantly from preoperatively to the 5- and 10-year mark. Although not significant, most items improved from 5 to 10 years postoperatively. Age positively correlated with the preoperative, 5-year, and 10-year follow-up FFI-D total score. Conclusions AMIC, as a single-step surgical intervention, is a viable long-term treatment option. Patient selection regarding symptoms and findings is vital to achieve satisfying results.
Anaesthetic modalities and post-operative outcomes in spinal cord injury urolithiasis: A systematic review
Authors: Qiu Matthew , Kuo Lu Yu , Rahman Adib , Ponen Kreyen , Zaka Ammar 
Published: December 2024

Objectives: Spinal cord injury (SCI) patients are at an increased risk of urolithiasis and are associated with increased perioperative morbidity and mortality. The optimal anaesthetic agent in these patients remains contentious, reflecting a paucity of large-scale clinical trials. This systematic review aims to summarise the existing evidence comparing general anaesthesia (GA) with non-GA induction for surgical treatment of stones for these patients. Materials and methods: Ovid MEDLINE, Cochrane, and PubMed databases were searched up to 30 March 2024. Eligible studies assessed SCI patients receiving surgical procedures for stones with a specified anaesthetic induction method detailed. Our primary outcomes were stone-free rate (SFR) and all-cause mortality. Secondary outcomes included intraoperative and post-operative complications, intensive care admissions, and mean hospital stay. Results: Fifteen cohort, observational, and case–control studies were included. The available data demonstrated no meaningful trend between cohorts receiving GA and non-GA induction, across all outcomes. Studies exhibited significant heterogeneity in the direct comparison of GA with non-GA methods. Type of non-GA method, incidence of complications and outcome reporting were inconsistently reported, precluding reliable meta-analysis. Methodological quality was scored on the modified Newcastle Ottawa Scale which found eligible studies to be of poor to good quality. Conclusion: Evidence around outcomes in non-GA and GA-induced treatment is inconclusive and poor. We suggest larger scale, prospective studies to further stratify risk of poor outcomes between these two groups.
Hospitalizations in patients with systemic sclerosis: Differences between limited and diffuse cutaneous subtypes
Authors: van Dantzig Philippa , Lao Chunhuan , Padala Sree Deepika , White Douglas , Solanki Kamal 
Published: December 2024

Aim: Systemic sclerosis is associated with significant morbidity and mortality. It remains unclear from the literature if there are differences between the subtypes of systemic sclerosis and the rate of hospitalization. Our study investigates the rates of all types of hospitalizations between limited and diffuse cutaneous systemic sclerosis. Methods: Patients have been collected prospectively using the European Scleroderma Trials and Research Group database at the Waikato Hospital, and were screened for inclusion criteria. Data were collected retrospectively on hospitalizations (total, acute, elective and infusion-related) for all patients. Results: Overall, 140 patients were included in the analysis with 84 (60.0%) with limited cutaneous systemic sclerosis, 40 (28.6%) with diffuse systemic sclerosis, 3 (2.1%) with systemic sclerosis sine scleroderma and 13 (9.3%) with overlap syndrome. The mean number of total hospitalizations in 12 months was 0.9 (SD 3.0) for patients with limited disease versus 1.7 (SD 3.0) for diffuse disease (p = 0.062). The mean number of acute hospitalizations in 12 months was 0.6 (SD 1.3) for limited and 1.2 (SD 2.4) for diffuse (p = 0.061). Patients with diffuse systemic sclerosis were more likely to be admitted for reasons relating to systemic sclerosis than patients with limited disease (p < 0.001). Conclusion: Diffuse and limited systemic sclerosis subtypes appear to have similar rates of hospitalizations though there is a trend in favour of diffuse disease towards more total and acute hospitalizations. There are clear differences in causes of hospitalization between the two main subgroups.
Investigation Study of Structure Real Load Spectra Acquisition and Fatigue Life Prediction Based on the Optimized Efficient Hinging Hyperplane Neural Network Model
Authors: Zhu Lin , Xing Benao , Li Xingbao , Chen Min , Jia Minping 
Published: December 2024

AbstractIn the realm of engineering practice, various factors such as limited availability of measurement data and complex working conditions pose significant challenges to obtaining accurate load spectra. Thus, accurately predicting the fatigue life of structures becomes notably arduous. This paper proposed an approach to predict the fatigue life of structure based on the optimized load spectra, which is accurately estimated by an efficient hinging hyperplane neural network (EHH-NN) model. The construction of the EHH-NN model includes initial network generation and parameter optimization. Through the combination of working conditions design, multi-body dynamics analysis and structural static mechanics analysis, the simulated load spectra of the structure are obtained. The simulated load spectra are taken as the input variables for the optimized EHH-NN model, while the measurement load spectra are used as the output variables. The prediction results of case structure indicate that the optimized EHH-NN model can achieve the high-accuracy load spectra, in comparison with support vector machine (SVM), random forest (RF) model and back propagation (BP) neural network. The error rate between the prediction values and the measurement values of the optimized EHH-NN model is 4.61%. In the Cauchy-Lorentz distribution, the absolute error data of 92% with EHH-NN model appear in the intermediate range of ±1.65%. Also, the fatigue life analysis is performed for the case structure, based on the accurately predicted load spectra. The fatigue life of the case structure is calculated based on the comparison between the measured and predicted load spectra, with an accuracy of 93.56%. This research proposes the optimized EHH-NN model can more accurately reflect the measurement load spectra, enabling precise calculation of fatigue life. Additionally, the optimized EHH-NN model provides reliability assessment for industrial engineering equipment.
The gender gap in the wage sensitivity of job transitions: a decomposition analysis
Authors: Detilleux Céline , Deschacht Nick 
Published: December 2024

AbstractPrevious research shows that female workers are less sensitive to wages in their decision to switch jobs than male workers, and that this could explain a substantial part of the gender wage gap. This paper studies to what extent gender differences in preferences and personality traits explain the gender gap in the wage-elasticity of job-to-job transitions in the labor market. Using a novel decomposition approach in the context of mediated moderation and using German Socio-Economic Panel Survey (G-SOEP) data for the period 2005–2019, we find that gender differences in risk preferences, patience, trust, reciprocity, altruism, conscientiousness, ambition and self-esteem explain about 25% of the gender gap in wage-elasticities of job separations. A detailed decomposition suggests that risk preferences, trust and ambition contribute most to this gender gap in wage-elasticity.
Provision of hospice and palliative care and implementation of advance care planning for residents in German nursing homes – a cross-sectional study
Authors: Berloge Christopher , Völkel Anna , Jacobs Hannes , Burger Birte , Stahmeyer Jona T. , Brütt Anna Levke , Hoffmann Falk , Schleef Tanja , Stiel Stephanie 
Published: December 2024

Abstract
Background
Demographic changes are leading to a rise in the demand for care services, with nursing homes (NHs) playing an increasingly important role in end-of-life care. Evidence suggests that NH residents at the end of life significantly benefit from hospice and palliative care and the implementation of advance care planning (ACP). In 2018, Germany passed a law to promote the implementation of ACP in NHs and to enable the refinancing of ACP services by the statutory health insurance funds. The present study aimed at assessing current hospice and palliative care structures, examining the implementation of ACP and identifying barriers to obtain approval for billing for ACP services under this specific legislative (§ 132 g SGB V).

Methods
As a part of the "Gut-Leben" project, the present study administered a cross-sectional quantitative survey in 2023 to evaluate hospice and palliative care structures, the implementation of ACP, and barriers to ACP approval in German NHs. A questionnaire was distributed to a random sample of N = 1,369 NH managers. Responses were analyzed using descriptive statistical methods.

Results
N = 330 NH managers responded to the questionnaire (24.1% response). The majority described the end-of-life care structures in their region as rather good (77.7; n = 256), and very strong collaboration was reported with general practitioners (54.7%), physiotherapists (42.9%), and palliative care physicians (38.6%). Awareness of the legislative for ACP was reported by n = 201 NHs (64.4%), and 100 (50.3%) of these NHs had already obtained approval. The primary barriers to approval identified by 68 NHs included a lack of available staff (48.5%; n = 33) and a small facility size (27.9%; n = 19).

Conclusions
Although half of the NHs have implemented ACP, there is still a need to enhance awareness of the ACP legislative. These efforts should aim to reduce the existing barriers to approval, which could be achieved, for instance, by fostering collaboration between NHs or by cooperating with external ACP service providers.
An improved HPAEC-PAD method for the determination of D-glucuronic acid and 4-O-methyl-D-glucuronic acid from polymeric and oligomeric xylan
Authors: Leontakianakou Savvina , Grey Carl , Karlsson Eva Nordberg , Sardari Roya R. R. 
Published: December 2024

AbstractGlucuronic acid (GlcA) is an abundant substituent in hardwood xylan, and it is often found in its methylated form as methyl glucuronic acid (MeGlcA). GlcA and MeGlcA are sugar acids, bound to the xylose backbone at position O-2, and their presence can affect the digestibility of the polymer. Currently, detection of released GlcA or MeGlcA from synthetic substrates such as pNP-glucuronic acid can be achieved with colorimetric assays, whereas analysis from natural substrates such as xylan is more complicated. High performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) with an isocratic elution profile has been proposed for quantification of uronic acids in acid-hydrolysed wood samples. However, achieving sufficient separation for comprehensive analysis of hardwood-related xylan components, particularly MeGlcA remains challenging with this methodology. This study offers modified protocols for improved separation by introducing gradient elution profiles to effectively separate hydrolysed hardwood-related compounds, including MeGlcA, and GlcA within a single analytical run. The method showed excellent reproducibility and a standard curve of MeGlcA assured first order linearity in a wide range of concentrations, making the method excellent for quantification.
The family talk intervention prevent the feeling of loneliness - a long term follow up after a parents life-threatening illness
Authors: Bergersen Emily , Olsson Cecilia , Larsson Maria , Kreicbergs Ulrika , Lövgren Malin 
Published: December 2024

Abstract
Background
The psychosocial needs of families in which a parent is affected by life-threatening illness and has dependent children are extensive. However, few family-based interventions have been scientifically evaluated and even fewer have been evaluated long term. Therefore, the specific objectives of this study were to describe the parents’ perceptions of the timing and length of FTI in relation to the illness trajectory, to explore what activities learnt by the FTI still were practiced in the long-term and what content of FTI was perceived as most valuable to cope in the long-term.

Methods
This qualitative study involved a follow-up with nine parents (ill parents, n = 3, coparents, n = 6) 4 to 5 years after participating in FTI, where one parent was cared for in specialised palliative homecare. FTI is a psychosocial family-based intervention that consists of 6–11 manual-based meetings with the families led by an educated interventionist. FTI focuses on facilitating family communication about illness-related subjects, supporting parenting, and making the children’s needs visible. The data collection consisted of interviews and was analysed according to the phenomenographic method, focused on variations in perceptions.

Results
The parents perceived FTI as a way to alleviate feelings of loneliness, and some families were still using the obtained communication tools at the time of the interview. They also perceived that FTI contributed to the children being more open about their own feelings and thoughts. However, the parents wanted extended support after FTI ended based on their individual needs, for example, during and after bereavement, deteriorated health or occasional challenges faced by children in crisis. The parents perceived the peer support gained in conjunction with FTI as important social and emotional support both during and after the intervention. The interventionists were perceived as professional persons who promoted open and honest communication during FTI.

Conclusion
FTI is found to promote family communication both in a short- and long-term perspectives according to parents. They also found FTI useful in reducing their feelings of loneliness. Support over a longer period of time is desired and extra FTI meetings may strengthen the family as a whole in parallel with additional support for parents and children during the illness trajectory and in bereavement. They received support in dealing with strong and difficult emotions and learned conversational techniques that they still used at the time of the interview, indicating that the lessons learnt was integrated and valuable many years after the last FTI meeting.
Neuroathletic training in stroke rehabilitation? A single-blind randomized controlled pilot study on the potential of neuroathletic training for balance ability in stroke outpatient rehabilitation
Authors: Judith Evers , Isabel Stolz , Marilena Klein 
Published: December 2024

AbstractRecently, neuroathletic training has been increasingly applied in competitive sports, in therapy, and in prevention. Scientific evidence on the effectiveness of this approach, however, has been poorly developed. Potentials of neuropathologic perceptual exercises to potentially improve balance control in the context of movement therapy in stroke rehabilitation appear promising. To investigate the possible effects of neuroathletic exercises on the balance ability of poststroke patients with ischemic infarcts and intracerebral hemorrhages, a controlled trial of a standardized protocol of daily neuroathletic exercises compared to traditional movement therapy during a four-week period of medical rehabilitation was conducted (n = 19). Patients were assessed with the Berg-Balance Scale (BBS), which represents the Gold standard for clinical measurement of balance. The results of the prepost BBS measurement showed significant balance improvements in the intervention and control groups, whereas the intervention group reached a higher total score by half the size of the standard deviation. A comparison of the results of both groups supported the general effectiveness of movement therapy for improving balance in stroke rehabilitation. However, neuroathletic training exercises did not lead to a stronger effect. Moreover, the intervention group did not score significantly lower than the control group. A negative influence can therefore not be assumed. For further investigations of neuroathletic training compared to treatment-as-usual training to improve balance in stroke rehabilitation, additional studies with larger sample sizes and longer treatment periods should be conducted.Trial registration United States National Library of Medicine, NCT06391801, date: 04.29.2024.
Recent progress of principal techniques used in the study of Müller glia reprogramming in mice
Authors: Yin Zhiyuan , Kang Jiahui , Xu Haoan , Huo Shujia , Xu Haiwei 
Published: December 2024

AbstractIn zebrafish, Müller glia (MG) cells retain the ability to proliferate and de-differentiate into retinal progenitor-like cells, subsequently differentiating into retinal neurons that can replace those damaged or lost due to retinal injury. In contrast, the reprogramming potential of MG in mammals has been lost, with these cells typically responding to retinal damage through gliosis. Considerable efforts have been dedicated to achieving the reprogramming of MG cells in mammals. Notably, significant advancements have been achieved in reprogramming MG cells in mice employing various methodologies. At the same time, some inevitable challenges have hindered identifying accurate MG cell reprogramming rather than the illusion, let alone improving the reprogramming efficiency and maturity of daughter cells. Recently, several strategies, including lineage tracking, multi-omics techniques, and functional analysis, have been developed to investigate the MG reprogramming process in mice. This review summarizes both the advantages and limitations of these novel strategies for analyzing MG reprogramming in mice, offering insights into enhancing the reliability and efficiency of MG reprogramming.
Graphical Abstract
“Just” energy? An ecofeminist analysis and critique of a predominant conception of energy
Authors: Calidori Noemi , Frigo Giovanni , Hillerbrand Rafaela 
Published: December 2024

Abstract
Background
This theoretical paper offers an ecofeminist analysis and critique of a specific conception of energy. The hypothesis is that, at least in the Western context, there is a characteristic socio-economic understanding of energy as a resource and commodity for human needs and the development of human societies. This conception corresponds to a cultural understanding that is both different from and broader than the scientific notion of energy. Such a conception has become part of several narratives, including energy policy. Our research question is: does this conception of energy as a commodity and resource affect the relation between humans and nature? And if so, how?

Results
Drawing on the work of Val Plumwood, and Greta Gaard, we argue that conceiving of energy as a resource and commodity for human needs and the socio-economic development of human societies reinforces and mediates the hierarchical and oppressive dualism “human-nature”, thus contributing to backgrounding, excluding, incorporating, and instrumentalizing some parts of nonhuman nature as well as some human groups.

Conclusions
The idea of energy as a commodity shapes public debates and policies, worsening existing environmental issues. This dominant perspective affects how people respond to environmental challenges and crises, both individually and collectively. This article aims to encourage more critical and open discussions about energy. It suggests that researchers and policymakers adopt more radical and less oppressive approaches in their academic work, benefiting both the human and non-human world.
Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke
Authors: Huang Zhihai , Xu Peisheng , Hess David C. , Zhang Quanguang 
Published: December 2024

AbstractTraumatic brain injury (TBI) and stroke pose major health challenges, impacting millions of individuals globally. Once considered solely acute events, these neurological conditions are now recognized as enduring pathological processes with long-term consequences, including an increased susceptibility to neurodegeneration. However, effective strategies to counteract their devastating consequences are still lacking. Cellular senescence, marked by irreversible cell-cycle arrest, is emerging as a crucial factor in various neurodegenerative diseases. Recent research further reveals that cellular senescence may be a potential driver for secondary neurodegeneration following brain injury. Herein, we synthesize emerging evidence that TBI and stroke drive the accumulation of senescent cells in the brain. The rationale for targeting senescent cells as a therapeutic approach to combat neurodegeneration following TBI/stroke is outlined. From a translational perspective, we emphasize current knowledge and future directions of senolytic therapy for these neurological conditions.
Promoting equity and justice: harnessing the right to food for Africa's food security
Authors: Onyeaka Helen , Siyanbola Kehinde Favour , Akinsemolu Adenike A. , Tamasiga Phemelo , Mbaeyi-Nwaoha Ifeoma Elizabeth , Okonkwo Clinton Emeka , Odeyemi Olumide A. , Oladipo Elijah Kolawole 
Published: December 2024

AbstractThis paper examines the state of food security in African nations within the context of promoting equity and justice through the right to food. It discusses the various challenges faced by the African nations, including poverty, climate change, and urbanization, which impact the availability, accessibility, and utilization of food resources. It further emphasises the importance of secure land tenure rights, gender equality and women empowerment, good nutrition and safe food, sustainable agricultural practices as well as sustainable food system transformation to ensure food and nutrition security, environmental quality and human well-being. This paper further advocates for stringent efforts involving governance, accountability, and international cooperation to achieve sustainable development goals and ensure food security for all in Africa, thereby fostering equity and justice in the food system.