bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinematic and Mechanical Analysis of the Ankle Rotating-Traction-Poking Manipulation
Authors: Chunyu Gao , Baojian Wang , Liguo Zhu , Gao Jinghua , Jianguo Li , Jian Li , Minshan Feng 
Published: December 2019

Abstract
Background: In China, the ankle rotating-traction-poking manipulation (RTPM) has been used to increase range of movement and reduce pain in patients with lateral ankle sprains. But no research so far has quantitatively analyzed the kinematic and mechanical data of RTPM therapy. Therefore, the purpose of the present study was to analyze the kinematics and mechanics of RTPM technique. Methods: A total of 60 volunteers who had ankle sprains participated in the study. A single physiotherapist specializing in RTPM worked with each of the subjects. Motion capture technology, self-developed mechanical gloves, and a data synchronization device were used to acquire kinematic and mechanical data during the RTPM. Results: The mean maximum force of the thumb, index finger, and middle finger during the rotating was 18.89 N, 10.26 N, and 9.51 N, respectively, that of the traction force was 18.61 N, 13.25 N, and 8.33 N, respectively, and that of the poking force was 26.5 N, 8.61 N, and 10.62 N, respectively. The average time of rotating for six circles was 11.36 s. The average linear velocity of rotating was 58.28 mm/s, and that of traction-poking was 23.81 mm/s. The average linear acceleration of rotating was 0.43 mm/s2, and that of traction-poking was 0.54 mm/s2. The average displacements of traction and poking were 36.94 mm and 22.44 mm, respectively. The average angle of traction and poking were 23.27° and 22.76°, respectively. Conclusions: The RTPM can be repeatable for clinical application, and also has features of gentleness, rhythmicity, and continuity.
Photosynthetic performance and growth responses of Liriope muscari (Decne.) L.H. Bailey (Asparagaceae) planted within poplar forests having different canopy densities
Authors: zhang jiaojiao , Zhou Jian , Zhu Ling , Zhang Xu 
Published: December 2019

Abstract
Background: Liriope muscari (Decne.) L.H. Bailey is a valuable horticultural and medicinal plant that grows under a range of light intensities, from high to low, in the understories of shrubs. To understand how this species adapts to these various environments, we selected two groups of lilyturf growing under poplar trees at two different spacings. Each group was divided into three types, open field, forest edge and shaded forest with high, medium and low irradiance levels, respectively, and then we examined their photosynthetic characteristics, physiology and biomasses. Results: Light saturation point, light compensation point and in situ net photosynthetic rate (PN) were highest in lilyturf growing under high. In contrast, lilyturf growing under low light had a higher apparent quantum yield and Chl a and b contents, indicating that they adapted to low light. Although the leaves of lilyturf growing under low light were small, their root tubers were heavier. Conclusions: The novelty of this research is the demonstration of the eco-physiological basis of lilyturf's shade adaptation mechanisms indicated by photosynthetic activity, chlorophyll fuorescence, Chla, Chlb and Car contents and grown in different irradiance. We believe that lilyturf is a shade-tolerant plant suitable for planting in undergrowth, but attention should be paid to the canopy density of the forest when interplanting.The findings presented here advance our understanding of the photosynthetic characteristics of understory plants and may assist in the optimization of irradiances in the furture. Keywords: chlorophyll fluorescence; diurnal course; light acclimation; light response curve; soil characteristics; path analysis.
Making researchers responsible: Attributions of responsibility and ambiguous notions of culture in research codes of conduct
Authors: Valkenburg Govert , Dix Guus , Tijdink Joeri , de Rijcke Sarah 
Published: December 2019

Abstract
Background Research codes of conduct offer guidance to researchers with respect to which values should be realized in research practices, how these values are to be realized, and what the respective responsibilities of the individual and the institution are in this. However, the question how the division between individual and institutional responsibilities is to be made, has hitherto received little attention. Therefore, we conduct an analysis of research codes of conduct, and investigate how responsibilities are positioned as individual or institutional ones and how the boundary between those two is shaped.Method We selected 12 codes of conduct that apply to medical research in the Netherlands, and performed a close-reading content analysis of these codes of conduct. We first identify dominant themes, and then investigate how responsibility is attributed to individuals and institutions.Results We observe that in many cases, the attribution of the responsibility to either the individual or the institution is not entirely clear and that the notion of culture appears as a residual category for such attributions. This notion of responsible research cultures is deemed important as something that mediates between the individual and institutional level, but at the same time largely lacks substantiation.Conclusions While many attributions of individual and institutional responsibility are clear, the exact boundary between individual and institutional responsibility is often problematic. We suggest two possible avenues for improvement in codes of conduct: either clearly attribute responsibilities to individuals or institutions and depend less less on the notion of culture, or make culture a more explicit concern and articulate what it is and how it could be fostered.
Indoxyl Sulfate and High-density Lipoprotein Cholesterol in Early Stages of Chronic Kidney Disease
Authors: Wang Li , Xiang Fangfang , Ji Jun , Zou Jianzhou , Chen Yunqin , Xue Ning , Zhang Lin , Jiang Xiaotian , Ding Xiaoqiang , Cao Xuesen 
Published: December 2019

Abstract
Background: High indoxyl sulfate (IS) levels and low high-density lipoprotein cholesterol (HDL-c) levels are both risk factors of cardiovascular diseases (CVD) in chronic kidney disease (CKD) patients, the connection between which has not been clearly clarified. This study aimed to explore the relationship between IS and HDL-c levels in early stages of CKD population. Methods: Patients of CKD stage 1-3 were enrolled in this cross-sectional study. Correlations between HDL-c and IS were investigated among various clinicopathological variables.Results: A total of 205 CKD patients (96 men) with a mean age of 43.3 years old were included in this research. There were 96 patients (46 men) in CKD stage1 and 109 (50 men) in CKD stage 2 or stage 3. IS levels were significantly higher in CKD 2+3 group (1.50±1.74μg/ml vs 0.94±0.66μg/ml, p=0.007), while HCL-c levels were lower (1.19±0.39mmol/L vs 1.33±0.45 mmol/L, p=0.017) compared to CKD 1 group. Among all the patients, a negative correlation was observed between IS and HDL-c levels (r=-0.244, p=0.001). IS level was an independent risk factor for low HDL-c (<1.04mmol/L) incidence even after controlling for potential confounders (OR=1.63, 95% CI: 1.11-2.39, p=0.013). IS and HDL-c were both risk factors for predicting CKD stage 3. Conclusions: Metabolic disorder of HDL-c occurs in early CKD stages, probably attributed by increased IS level. Early management of dyslipidemia and uremic toxin retention is important for delaying disease progression and preventing cardiovascular events. Keywords: Indoxyl sulfate, High-density lipoprotein cholesterol, Chronic kidney disease, Cardiovascular disease, Lipids
The role of the MTG in negative emotional processing in young adults with autistic traits: a fMRI task study
Authors: Yu Yaxu , Wang Xiaoqin , Ward Jamie , Jiang Qiu 
Published: December 2019

Abstract
Individuals with autistic traits are those within the normal population who demonstrate social, communication, and cognitive impairments but who do not meet the clinical threshold for autism spectrum disorder (ASD). ASD is a pervasive neurodevelopmental disorder associated with deficits in high-level cognitive functions such as negative emotion processing and social cognitive processing, and people with autistic traits also have these impairments. Few previous studies have explored negative emotion processing in people with autistic traits using task-based functional magnetic resonance imaging (fMRI). In this study, we focused on the behaviors of a large sample (N=104) of Chinese individuals with different levels of autistic traits, who we tested using a popular questionnaire called the autism spectrum quotient (AQ). We then applied task fMRI to determine negative emotion processing and social cognition associated with differences in brain activation and functional connectivity. The results mainly showed significantly positive activation in the right middle temporal gyrus (MTG), and the right hippocampus gyrus (HG) in multiple regression analysis. More importantly, mediation analysis showed that the right MTG suppresses the relationship between AQ (total) score and negative emotional processing, showing that a higher autistic trait score in individuals leads to a smaller difference between the rating of negative images and the neutral images. Furthermore, generalized psychophysiological interaction analyses (gPPI) analysis also suggested that the right MTG shows significant functional connectivity (FC) with the left parahippocampal gyrus (PHG), suggesting that individuals with autistic traits have high level of spontaneous negative emotion. According to these findings, we assumed that the MTG might have a specific effect on processing negative emotion in individuals with autistic traits related to weaker to social emotion ability. The emotion perception mechanisms in the MTG region may be affected by atypical negative emotion processing in other brain regions such as HG and PHG, during a negative emotion processing task with socially emotion-relevant information in individuals with autistic traits.
Microglia depletion by administration of a colony-stimulating factor 1 receptor antagonist exacerbates inflammation-induced fatigue in mice
Authors: Vichaya Elisabeth G. , Ford Bianca G. , Dantzer Robert 
Published: December 2019

Abstract
Background: Production of inflammatory mediators by activated microglial cells in the central nervous system is commonly considered to be responsible for the development of symptoms of depression including fatigue and lack of energy (anergia) in response to systemic inflammation. Methods: In order to directly test the validity of this hypothesis, male C57BL/6 mice were treated orally with PLX5622, a specific antagonist of colony stimulating factor receptor to eliminate microglia before administration of a fatigue-inducing dose of lipopolysaccharide (LPS) according to a 2 (PLX5622 versus control diet) x 2 (LPS x control) factorial design. Fatigue was measured by decreased wheel running activity. Results: Chronic administration of PLX5622 eliminated microglia and peripheral tissue macrophages. However, it did not abrogate the inducible expression of proinflammatory cytokines in the brain in response to LPS. Instead PLX5622 increased IL-6 and abrogated IL-10 response to LPS. PLX5622 had only moderate effects on the liver inflammatory response to LPS. In accordance with these neuroimmune effects, PLX5622-treated mice responded to LPS with the same level of decreased locomotor activity in a new environment as mice given the control diet. Further, PLX5622-treated mice displayed a prolonged decrease in running wheel activity. In addition, PLX5622-treated mice were less active in running wheels than mice given the control diet even in baseline conditions. Conclusions: These findings reveal a role for microglia in the regulation of immune-to-brain signaling that is different from the one usually ascribed to it and call for a re-evaluation of the importance of microglia in the brain response to physical exercise.
The Effects of a Novel Inhibitor of Tumor Necrosis Factor (TNF) Alpha on Prepulse Inhibition and Microglial Activation in Two Distinct Rodent Models of Schizophrenia
Authors: Shelton Heath W. , Gabbita Somasundar Prasad , Gill W. Drew , Burgess Katherine C. , Whicker Wyatt S. , Brown Russell W. 
Published: December 2019

Abstract
Background: Increased neuroinflammation has been shown in individuals diagnosed with schizophrenia (SCHZ). This study evaluated a novel immune modulator (PD2024) that targets the pro-inflammatory cytokine tumor necrosis factor-alpha (TNFα) to alleviate sensorimotor gating deficits and microglial activation employing two different rodent models of SCHZ. Methods: In Experiment 1, rats were neonatally treated with saline or the dopamine D2-like agonist quinpirole (NQ; 1 mg/kg) from postnatal day (P) 1-21 which produces increases of dopamine D2 receptor sensitivity throughout the animal’s lifetime. In Experiment 2, rats were neonatally treated with saline or the immune system stimulant polyinosinic:polycytidylic acid (Poly I:C) from P5-7. Neonatal Poly I:C treatment mimics immune system activation associated with SCHZ. In both experiments, rats were raised to P30 and administered a control diet or a novel TNFα inhibitor PD2024 (10mg/kg) in the diet from P30 until P67. At P45-46 and from P60-67, animals were behaviorally tested on auditory sensorimotor gating as measured through prepulse inhibition (PPI). Results: NQ or Poly I:C treatment resulted in PPI deficits, and PD2024 treatment alleviated PPI deficits in both models. Results also revealed that hippocampal microglial activation produced by neonatal Poly I:C was significantly reduced to control levels by PD2024. In addition, a separate group of animals neonatally treated with saline or Poly I:C from P5-7 demonstrated increased TNFα protein levels in the hippocampus, verifying increased TNFα in the brain produced by Poly I:C. Conclusions: Results from this study suggests that that brain TNFα is a viable pharmacological target to treat the neuroinflammation known to be associated with SCHZ.
Effectiveness of orthodontic temporary anchorage devices in canine retraction and anchorage preservation during two-step technique: A systematic review and meta-analysis
Authors: Tian Haonan , Xie Congman , Lin Min , Yang Hongmei , Ren Aishu 
Published: December 2019

Abstract
Background: To assess the effectiveness of orthodontic temporary anchorage devices in canine retraction during two-step technique. Methods: The search was systematically performed up to June 2019 in five electronic databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Scopus). A risk of bias assessment was performed using the Cochrane Risk of Bias Tool for Randomized Controlled Trials (RCTs) and the Risk of Bias in Nonrandomized Studies - of Interventions (ROBINS-I) tool for controlled clinical trials (CCTs) . The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach was applied for quality assessment. Data concerning the mean difference in mesial molar movement and extent of canine retraction were extracted for statistical analysis. The mean difference and 95% confidence interval were analyzed for continuous data. A meta-analysis with a random-effects model for comparable outcomes was carried out. Results: Three RCTs and five CCTs were finally included. Meta-analysis showed a significant increase not only in anchorage preservation in the implant anchorage group in both the maxilla (1. 56 mm , 95% CI: 1.14 to 1.98, P <0.00001 ) and the mandible (1.62 mm , 95% CI: 1.24 to 2.01, P <0.00001 ) but also in canine retraction in the implant anchorage group in both the maxilla (0.43 mm , 95% CI: 0.16 to 0.69, P =0.001 ) and the mandible (0.26 mm , 95% CI: 0.02 to 0.49, P =0.03 ). Conclusions: Very low-quality evidence shows that implant anchorage is more efficient than conventional anchorage during canine retraction. Further high-quality studies are needed.
Strategies to reach and motivate migrant communities at high risk for TB to participate in latent tuberculosis infection screening program: a community-engaged mixed methods study among Eritreans
Authors: Spruijt Ineke , Haile Dawit Tesfay , Erkens Connie , Hof Susan van den , Goosen Simone , Kate Andrea ten , Teshome Hewan , Karels Marja , Koenders Marga , Suurmond Jeanine 
Published: December 2019

Abstract
Background: In the Netherlands, migrant populations with a high TB incidence are an important target group for TB prevention programs. However, there is a lack of insight in community-engaged strategies to reach and motivate those migrants to participate in a latent TB infection (LTBI) education, screening and treatment program.Methods: In co-creation with Eritrean key figures and TB care staff, we designed and executed six strategies to reach and motivate Eritrean communities to participate in LTBI screening and treatment programs in five regions in the Netherlands. We registered participation in LTBI education and screening, and uptake and completion of LTBI treatment. We used semi-structured group and individual interviews with Eritrean participants and key figures, and TB care staff to identify program facilitators and barriers.Results: Uptake of LTBI education and consequent screening varied between strategies (13% - 75% and 10% - 124% respectively). The program resulted in high treatment initiation and completion (both 97%) among those diagnosed with LTBI. Strategies using face-to-face promotion and targeting smaller groups were most successful. Reported program barriers included: competing priorities in the target group, perceived good health, poor risk perception, and skepticism towards the program purpose. TB staff perceived the program as useful but demanding in terms of human resources.Conclusions: Migrant communities can be successfully reached and motivated for LTBI screening and treatment programs, when sufficient (human) resources are in place and community-members, well connected to and trusted by the community, are engaged in the design and execution of the program.
Human Papillomavirus Vaccination in Hmong-American Adolescents: A Participatory Focus Group Study
Authors: Xiong Serena , Kasouaher Maiyia Y. , Vue Bai , Culhane-Pera Kathleen A. , Pergament Shannon L. , Desai Jay , Lee Hee Yun 
Published: December 2019

Abstract
Background: Human papillomavirus (HPV) vaccination rates in Asian-American/Pacific- Islander (AAPI) populations are substantially lower than majority Americans. No studies have assessed HPV vaccine rates in the Hmong population, an AAPI group with increased risks of cervical and nasopharyngeal cancer. In 2015, the HPV vaccinations rates for Hmong girls and boys ages 9-17 at a Minnesota community health center (CHC) were 32% and 20%, lower than national 2017 HPV rates of 47% and 53%. This qualitative community-based participatory action research study identified multilevel barriers, facilitators, and decision-making processes about HPV vaccinations among Hmong adolescents and parents. Methods: Bilingual community researchers recruited Hmong adolescents and their parents from a community health center, conducted eight focus groups with 12 adolescents and 13 parents. Participants also completed demographic and HPV knowledge surveys. The research team analyzed transcripts using participatory thematic analysis and identified themes using a multilevel socioecological model combined with an assets lens. Results: Both survey and focus group results showed that Hmong adolescents and parents had low levels of HPV and HPV vaccine awareness. At the individual-level, both adolescents and parents reported concerns about side-effects and cost as reasons for not getting any type of vaccination, however they also expressed a strong desire to learn about HPV and the HPV vaccine. Community-level barriers identified included community narratives around traumatic experiences with vaccines, and facilitators included family and community connections and communications. At the institutional-level, barriers included structural constraints in health care settings, while facilitators included ease of obtaining vaccines at school-based clinics and provider authoritative decision-making. Finally, there was a range of decision-making processes between parents and adolescents and between parents and providers. Conclusion: A linguistically and culturally-specific HPV educational program for Hmong adolescents and parents could address barriers and build on facilitators and assets to promote HPV vaccine uptake. These findings have informed the development of an eHealth application to increase HPV vaccinations in Hmong adolescents. Future research will test the feasibility, acceptability, and efficacy of culturally-tailored, multilevel HPV vaccination interventions that may provide evidence about the efficacy of culturally-appropriate education in comprehensive vaccine strategies.
Personalizes Social Support for non-dependent old persons decrease significantly caregivers’ burden: a longitudinal study of 876 old persons and their caregiver.
Authors: Arlotto Sylvie , Gentile Stéphanie , Durand Anne Claire , Bonin-Guillaume Sylvie 
Published: December 2019

Abstract
Background. Informal care provided by family caregivers in old persons is associated to a high risk of burden and poor health status. This study aimed to analyze the impact of a Personalized Social Support (PSS) attributed to non-dependent old persons living in the community on caregiver burden, satisfaction and frailty. Methods. This non-interventional longitudinal study was performed in the south East area of in France: old persons asking for a PSS (>70 years old, with no disability and no severe chronic disease, living at home) and their caregiver were included with a 6-months follow up. Dyads were visited at home by social workers. Caregivers Burden has been assessed with Mini-Zarit and frailty status with FiND (Frail Non-Disable). Results. 876 dyads (old persons: female 77.6%, aged 82.2 ± 5.8 years old; caregivers: 64.5% female, 29% spouse, 61% children; 64% with frailty and 38% with high burden (high burden being significantly associated with frailty)) were eligible for a PSS. The follow-up was possible completed for 686 of them (78.3%). Among them, 569 PSS were financed, mainly: housekeeping and meal preparation. At follow-up, 53% of caregivers who had PSS experienced fewer difficulties in caring for their old person. Whether or not they received the PSS, 73% of the caregiver had a lower burden level, only 6% had a persistent high burden; 17% of them were less frail and 18% felt their health status was better than at the time of inclusion. 61,5% of caregivers who had PSS were totally satisfied. Conclusions. Our study highlight that the burden occurs also in non-dependent old person’s caregivers. Social support implementation for activity of daily living had a major impact on the burden but not on the caregiver frailty, which means that determinants of caregiver’s frailty are more complex and further studies are needed.