bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marijuana Use Among Young Adults (18–44 Years of Age) and Risk of Stroke
Authors: Parekh Tarang , Pemmasani Sahithi , Desai Rupak 
Published: November 2019

Background and Purpose—
Amidst legalization of therapeutic and recreational use of marijuana/cannabis in the United States, cerebrovascular effects of marijuana use remain largely unknown, especially among young adults. We aimed to examine the association between marijuana use (18–44 years) among young adults and stroke events.

Methods—
The study analyzed pooled data from the Behavioral Risk Factor Surveillance System (2016–2017)—a nationally representative cross-sectional survey collected by the Centers for Disease Control and Prevention. Weighted logistic regression models were used to examine an association of recent marijuana use (within the last 30 days) and stroke in young adults (18–44 years) adjusting for patient demographics, risk behavior, and relevant comorbidities.

Results—

Overall, 13.6% of participants (n=43 860; weighted 35.5 million; 49.9% men) reported using marijuana recently (in the last month), with 63.3% of them being men. Compared with nonusers, marijuana users were often younger (18–34 years; 73.8% versus 61%), non-Hispanic white or black, and with some college education. Marijuana users were often physically active (81.8% versus 77.5%), heavy drinkers (16.8% versus 4.9%), current combustible cigarette users (37.9% versus 15%) and had lower prevalence of hypertension, diabetes mellitus, and hyperlipidemia as compared with nonusers (
P
<0.01). Young adults with recent marijuana use showed 1.82× higher odds (adjusted odds ratio, 1.82 [95% CI, 1.08–3.10]) of stroke compared with nonusers, which further increased to 2.45× higher (adjusted odds ratio, 2.45 [95% CI, 1.31–4.60]) among frequent marijuana users (>10 days/month). Compared with nonusers, stroke odds were even higher among frequent marijuana users with concomitant combustible cigarette use (adjusted odds ratio, 3.12 [95% CI, 1.40–6.97]) and e-cigarette use (adjusted odds ratio, 2.63 [95% CI, 1.07–6.46]), respectively.

Conclusions—
There may be a significantly higher odds of stroke in young marijuana users (18–44 years) as compared with nonusers with even greater odds among frequent users (>10 days/month).
<p class="HeadingRunIn"><strong>Redescription of<em> Capitella capitata</em> (Fabricius) from West Greenland and designation of a neotype (Polychaeta, Capitellidae)</strong></p>
Authors: BLAKE JAMES A. 
Published: November 2019

Capitella capitata (Fabricius, 1780), the type species of the genus, was originally described from the SW coast of Greenland; however, current definitions of the species are largely based on Eisig (1887), who described specimens from Naples on the Mediterranean coast. Eisig’s excellent account of the morphology of a sexually dimorphic species has subsequently been applied to specimens collected from worldwide locations. C. capitata was considered cosmopolitan in its distribution until J.P. Grassle and others identified numerous sibling species in laboratory culture. A large collection of Capitella from locations along the W, SW, and SE coasts of Greenland was provided by the Zoological Museum, University of Copenhagen (ZMUC). The collections included about 680 specimens with distinctive prostomial, thoracic, and setal morphology that differs from the typical depiction of the species in most faunal accounts. A neotype was selected from an excellent collection of approximately 250 specimens from Mârmorilik on the Affarlikassâ Fjord on the inner Uummannaq Fjord system, north of Disko Bay. All available collections from the ZMUC are believed to belong to the same species, which is here considered to be Arctic and subarctic in distribution. Additional material from the Alaskan Arctic supports this hypothesis. The Greenland species has a short, cup-shaped, wider-than-long prostomium joined to a narrow peristomial ring that is retracted slightly into setiger 1. In most specimens, the first four thoracic setigers gradually increase in size, with setiger 4 being the largest thoracic segment, and then decrease over the next five setigers, with setiger 9 being smaller than subsequent anterior abdominal segments. The thoracic region is thus markedly distinct visually from the abdominal region. Setigers 8–9 typically lack fascicles of notosetae, but 80% of the specimens examined have genital spines and most have copulatory organs that are secretory in nature: they contain numerous small secretion granules but no sperm. Many of these specimens have eggs and larvae within their tubes, suggesting functional hermaphroditism. The present redescription of C. capitata serves to establish a baseline against which the many known but undescribed species can be compared. Previous accounts of C. capitata based on the Eisig concept and largely from boreal and temperate localities should be reevaluated.
<strong>Diversity, distribution, ecology and biogeography of caddisflies (Insecta: Trichoptera) in the Krka River (National Park “Krka”, Croatia)</strong>
Authors: KUČINIĆ MLADEN , VUČKOVIĆ IVAN , KUTNJAK HRVOJE , JELASKA LUCIJA ŠERIĆ , MARGUŠ DRAGO 
Published: November 2019

The caddislfies fauna is poorly known in the karstic area which covers about 50% of the entire territory of the Republic of Croatia. The Krka River is a karstic Mediterranean river with specific travertine barriers and 2 lakes. The spring of the Krka River is located 45 kilometres from the coast. The river flows into the Adriatic Sea near the city of Šibenik. In 1998 and 1999, systematic collecting of Trichoptera was performed in that area, and in 2000, 2005, 2007 and 2009 caddisflies were collected periodically. Sampling was performed at 9 locations representing different types of habitats: springs, travertine barriers, upper, middle and lower parts of the Krka River and lakes. During 16 on–site visits, 4792 adults were collected, belonging to 50 species. Diversity, distribution, ecology and biogeography of this material were analyzed.
Two new genera of Trachyphloeini with a key to the genera of small terricolous South African Trachyphloeini and Embrithini (Coleoptera: Curculionidae: Entiminae)
Authors: BOROVEC ROMAN , SKUHROVEC JIŘÍ 
Published: November 2019

Two new genera, Barclayanthus Borovec & Skuhrovec, gen. nov. and Janakius Borovec & Skuhrovec, gen. nov., assigned to the tribe Trachyphloeini Lacordaire, 1863, are described for three South African species of weevil: Barclayanthus micros Borovec & Skuhrovec, sp. nov., B. cooteri Borovec & Skuhrovec, sp. nov. and Janakius sylvaticus Borovec & Skuhrovec, sp. nov. All species are illustrated and keyed. The taxonomic status of each of the new genera is discussed, and compared with similar genera of Trachyphloeini and Embrithini Marshall, 1942. A key to known small terricolous South African genera of both Trachyphloeini and Embrithini is included.
What constitutes recovery in schizophrenia? Client and caregiver perspectives from South India
Authors: Gopal Subhashini , Mohan Greeshma , John Sujit , Raghavan Vijaya 
Published: November 2019

Background: Understanding the concept of recovery in severe mental illnesses such as schizophrenia from the social and cultural aspects is important as it will help in developing models of recovery and appropriate interventions. Client and caregiver perspectives on recovery play a significant role in shaping these models and interventions. Hence, the aim of this study was to understand how clients with schizophrenia and their caregivers perceive recovery and to examine the differences between male and female clients with schizophrenia. Materials and methods: A total of 100 clients with schizophrenia and 80 caregivers of clients with schizophrenia were included in the study after written informed consent. A semi-structured proforma was used to collect the sociodemographic profile and illness variables. A questionnaire was developed to assess the indicators of recovery from mental illness and was administered to study participants. Descriptive statistics including frequency and percentages were used along with the chi-square test for analysis. Results: The most common indicators of recovery for the clients with schizophrenia were absence of symptoms (88%), no relapse (70%) and going back to work (70%), while for the caregivers were absence of symptoms (100%), becoming independent (92.5%) and no relapse (91%). Indicators of recovery were similar between male and female clients with schizophrenia except for the need to stop medication as an indicator of recovery observed significantly more in females ( p = .006). Most clients used internal validation of indicators to assess their recovery (79%). Conclusion: Results indicate that clients and caregivers from India perceive recovery as being symptom free, able to go back to work and being independent. Clients with schizophrenia use internal validation to assess recovery. Gender does not play a role in the perceptions toward recovery in schizophrenia. These results will help in developing models of recovery for severe mental illness in Indian context leading to tailored interventions.
Interpersonal Tensions and Pain Among Older Adults: The Mediating Role of Negative Mood
Authors: Fuentecilla Jamie L. , Huo Meng , Birditt Kira S. , Charles Susan T. , Fingerman Karen L. 
Published: November 2019

Objectives: To examine whether (a) negative social encounters and physical pain are linked throughout the day, (b) negative mood mediates these associations, and (c) these associations vary by closeness with social partners. Method: Adults aged 65+ ( n = 313) completed ecological momentary assessments and reported their negative social encounters, physical pain, and mood every 3 hr throughout the day for 5–6 days. Results: Multilevel models revealed that negative social encounters were associated with greater pain at each 3-hr interval and that this association was mediated by negative mood during the same interval. Negative encounters with less close partners were associated with pain, but negative encounters with close partners were not. Discussion: Regulating older adults’ negative emotions may be crucial to improving their daily pain. Further, interventions focusing on negative encounters with less close partners in daily life may help mitigate older adults’ experiences of pain throughout the day.
Inhibition of PPARγ by bisphenol A diglycidyl ether ameliorates dexamethasone-induced osteoporosis in a mouse model
Authors: Wang Yaoqing , Pan Zhenyu , Chen Fan 
Published: November 2019

Objectives Bisphenol A diglycidyl ether (BADGE) is an antagonist for PPARγ that reduces bone marrow adiposity and increases bone formation in some animal models of osteoporosis and osteonecrosis. However, the effect of BADGE treatment on glucocorticoid-induced osteoporosis is unknown. This study investigated the preventive effects of BADGE on steroid-induced osteoporosis in mice. Methods Thirty-six female C57BL/6J mice were randomly divided into normal (phosphate-buffered saline), model (50 mg/kg dexamethasone sodium phosphate [Dex]), and BADGE (30 mg/kg of BADGE, combined with Dex) groups. All groups received intraperitoneal injections of their treatments, daily for 4 weeks. Protein and mRNA expression levels of gene markers were measured. Micro-computed tomography was used to measure physical parameters of femurs. Bone histomorphology was analyzed by hematoxylin and eosin staining. ELISA was used to measure serum osteocalcin and C-terminal telopeptide of type I collagen (CTX-1). Results Glucocorticoid treatment enlarged the marrow fat, concomitant with bone deterioration; BADGE treatment reversed steroid-induced marrow adiposity. Compared with the model group, BADGE treatment improved bone quality and increased bone volume, while increasing osteogenic markers and reducing adipogenic markers at both mRNA and protein levels; moreover, it reduced serum CTX-1 and increased serum osteocalcin. Conclusion BADGE treatment ameliorates glucocorticoid-induced osteoporosis by inhibiting PPARγ.
Expression of serum microRNA-155 and its clinical importance in patients with heart failure after myocardial infarction
Authors: Zhang Baojian , Li Biao , Qin Fen , Bai Fan , Sun Chao , Liu Qiming 
Published: November 2019

Objective This study was conducted to investigate the level of microRNA-155 (miRNA-155) in patients with heart failure (HF) after myocardial infarction (MI) and its clinical importance. Methods Serum miRNA-155 levels were measured using quantitative reverse transcription (qRT)-PCR. The left ventricular ejection fraction (LVEF), left ventricular posterior wall thickness, and left ventricular end-diastolic diameter were measured by echocardiography. Serum amino-terminal pro-B-type natriuretic peptide (NT-proBNP) and other parameters were also analyzed. Results miRNA-155 levels in patients with HF were significantly higher than in control and MI groups. The area under the receiver operating characteristic curve of serum miRNA-155 in the diagnosis of HF after MI was 0.941, the cutoff value was 1.77, sensitivity was 92.73%, and specificity was 92.14%. NT-proBNP levels were significantly higher and LVEF was lower in patients with high versus low miRNA-155 expression. Conclusions Patients with HF after MI had elevated miRNA-155 levels and poor cardiac function, suggesting that determining miRNA-155 expression could be used to assess the severity of the disease.
Video Analysis of Shoulder Dislocations in Rugby: Insights Into the Dislocating Mechanisms
Authors: Montgomery Connor , O’Briain David E. , Hurley Eoghan T. , Pauzenberger Leo , Mullett Hannan , Moran Cathal J. 
Published: November 2019

Background: Mechanisms previously described for traumatic shoulder injuries in rugby may not adequately describe all the mechanisms that result in shoulder dislocations. Purpose: To investigate the mechanism of shoulder dislocation events in professional rugby players through use of systematic video analysis. Study Design: Case series; Level of evidence, 4. Methods: In our series, 39 cases of shoulder dislocations from games played in top professional leagues and international matches across a 2-year period were available for video analysis. All cases were independently assessed by 2 analysts to identify the sequence of events occurring during shoulder dislocation. This included injury circumstance such as contact with another player or the ground, game scenario, injury timing, and the movements and force vectors involved in the dislocation mechanism. Results: We identified 4 distinct injury mechanisms. The previously described mechanisms “try scorer,”“tackler,” and “direct impact” were identified in 67% of cases. We describe a new injury mechanism occurring in the “poach position,” accounting for 18% of all shoulder dislocations studied. The remaining 15% could not be categorized. Shoulder dislocations occurred to a ball carrier in 15% of cases (n = 6) and a non–ball carrier in 85% of cases (n = 33). The injury most commonly occurred during a tackle (49%; n = 19) followed by ruck/maul (26%; n = 10). Time of injury showed that 36% (n = 14) of cases occurred in the last quarter of the game. Conclusion: Shoulder dislocations have now been shown to occur predominantly as a result of 1 of 4 distinct mechanisms, most frequently in the second half of the game. A new mechanism for shoulder dislocation has been described in this series, termed the poach position.
The Safety of Blood Flow Restriction Training as a Therapeutic Intervention for Patients With Musculoskeletal Disorders: A Systematic Review
Authors: Minniti Melissa C. , Statkevich Andrew P. , Kelly Ryan L. , Rigsby Victoria P. , Exline Meghan M. , Rhon Daniel I. , Clewley Derek 
Published: November 2019

Background: The effectiveness of blood flow restriction training (BFRT) as compared with other forms of training, such as resistance training, has been evaluated in the literature in clinical and nonclinical populations. However, the safety of this intervention has been summarized only in healthy populations and not in clinical populations with musculoskeletal disorders. Purpose: To evaluate the safety and adverse events associated with BFRT in patients with musculoskeletal disorders. Study Design: Systematic review. Methods: A literature search was conducted with 3 online databases (MEDLINE, CINAHL, and Embase). Eligibility criteria for selecting studies were as follows: (1) BFRT was used as a clinical intervention, (2) study participants had a disorder of the musculoskeletal system, (3) authors addressed adverse events, (4) studies were published in English, and (5) the intervention was performed with human participants. Results: Nineteen studies met eligibility criteria, with a pooled sample size of 322. Diagnoses included various knee-related disorders, inclusion body myositis, polymyositis or dermatomyositis, thoracic outlet syndrome, Achilles tendon rupture, and bony fractures. Nine studies reported no adverse events, while 3 reported rare adverse events, including an upper extremity deep vein thrombosis and rhabdomyolysis. Three case studies reported common adverse events, including acute muscle pain and acute muscle fatigue. In the randomized controlled trials, individuals exposed to BFRT were not more likely to have an adverse event than individuals exposed to exercise alone. Of the 19 studies, the adverse events were as follows: overall, 14 of 322; rare overall, 3 of 322; rare BFRT, 3 of 168; rare control, 0 of 154; any adverse BFRT, 10 of 168; any adverse control, 4 of 154. A majority of studies were excluded because they did not address safety. Conclusion: BFRT appears to be a safe strengthening approach for knee-related musculoskeletal disorders, but further research is needed to make definitive conclusions and to evaluate the safety in other musculoskeletal conditions. Improved definitions of adverse events related to BFRT are needed to include clear criteria for differentiating among common, uncommon, and rare adverse events. Finally, further research is needed to effectively screen who might be at risk for rare adverse events.
An AUC Target Simulation for Vancomycin in Patients With Class III Obesity
Authors: Langton Meagan M. , Ahern John W. , MacDougall Julie 
Published: November 2019

Objective: The objective of this simulation is to compare 24-hour vancomycin (Vanc24) dosage requirements between a target area under the curve (AUC) versus a target trough approach in patients with class III obesity. Methods: Adult patients were included if they received vancomycin in accordance with the University of Vermont Medical Center’s class III obesity dosage protocol from June 2016 through December 2018. Patient-specific pharmacokinetic parameters were calculated for each patient using the Sawchuck-Zaske method. For this simulation, Vanc24 dosages were calculated to achieve an AUC of 400 mg/L h and a trough concentration of 15 mg/L. Results: Sixty-three patients had Vanc24 dosage requirements calculated. The median age was 59 years (interquartile range [IQR]: 51.5-68), body mass index (BMI): 45.7 kg/m2 (IQR: 42.4-51.5), and 50.7% were male. The mean Vanc24 dosage requirements were 3995 mg (standard deviation [SD] ±1673) in the target trough approach versus 2783 mg (SD ±1149) in the target AUC approach ( P < .0001). Conclusion: A target AUC approach required less vancomycin over a 24-hour time period relative to a target trough approach. Vancomycin therapeutic drug monitoring that explicitly targets AUC may reduce vancomycin exposure and potentially decrease the risk of nephrotoxicity in patients with class III obesity.
Effect of tunneled and nontunneled peripherally inserted central catheter placement: A randomized controlled trial
Authors: Dai Can , Li Jia , Li Qiu-mei , Guo Xiuquan , Fan Yu-ying , Qin Hui-ying 
Published: November 2019

Purpose: To compare the effect of tunneled and nontunneled peripherally inserted central catheter placement under B-mode ultrasound. Methods: A single center, randomized, controlled, nonblinded, prospective trial was conducted in Guangzhou, China, between July 2018 and May 2019. A total of 174 participants were randomized to the experimental group (tunneled peripherally inserted central catheter) or the control group (nontunneled peripherally inserted central catheter) and were followed until extubation. Basic characteristics, peripherally inserted central catheter characteristics, the incidence of complications, and the costs of peripherally inserted central catheter placement and maintenance were collected. Data were analyzed by intention-to-treat. Results: A total of 168 of the participants had successful peripherally inserted central catheter placements (85/87, 97.7% in the experimental group and 83/87, 95.4% in the control group, P = 0.682). Compared to the control group, the experimental group had a lower incidence of complications during the placement (18.4% vs 32.2%, P = 0.036), a lower incidence of wound oozing (27.6% vs 57.5%, P < 0.001), a lower incidence of medical adhesive–related skin injury (9.2% vs 25.3%, P = 0.005), a lower incidence of venous thrombosis (1.1% vs 9.2%, P = 0.034), a lower incidence of catheter dislodgement (1.1% vs 9.2%, P = 0.034), and lower costs of peripherally inserted central catheter maintenance at 1, 2, and 3 months ( P < 0.05). Conclusion: Tunneled peripherally inserted central catheter may be recommended for good effectiveness.
Time-limited trials: A qualitative study exploring the role of time in decision-making on the Intensive Care Unit
Authors: Lonergan Bradley , Wright Alexandra , Markham Rachel , Machin Laura 
Published: November 2019

BackgroundWithholding and withdrawing treatment are deemed ethically equivalent by most Bioethicists, but intensivists often find withdrawing more difficult in practice. This can lead to futile treatment being prolonged. Time-limited trials have been proposed as a way of promoting timely treatment withdrawal whilst giving the patient the greatest chance of recovery. Despite being in UK guidelines, time-limited trials have been infrequently implemented on Intensive Care Units. We will explore the role of time in Intensive Care Unit decision-making and provide a UK perspective on debates surrounding time-limited trials.MethodsThis qualitative study recruited 18 participants (nine doctors, nine nurses) from two Intensive Care Units in North West England for in-depth, one-to-one semi-structured interviews. A thematic analysis was performed of the data.ResultsOur findings show time is utilised by Intensive Care Unit staff in a variety of ways including managing uncertainty when making decisions about a patient’s prognosis or the reversibility of a disease, constructing relationships with patients’ relatives, communicating difficult messages to patients’ relatives, justifying resource allocation decisions to colleagues, and demonstrating compassion towards patients and their families.ConclusionsTime shifts the balance towards greater certainty in Intensive Care Unit decision-making, by demonstrating futility, and can ease the difficult transition for staff and families from active treatment to palliation. However, this requires clear and open communication, both within the Intensive Care Unit team and with the family, being prioritised when time is used in decision-making.