bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical treatment of nasolabial cysts in a single institute
Authors: Lee D H , Yoon T M , Lee J K , Lim S C 
Published: January 2020

AbstractObjectivesTo analyse the results of treatment for nasolabial cysts according to whether an intraoral sublabial or endoscopic transnasal approach was used, and to determine the recent surgical trend in our hospital.MethodsTwenty-four patients with a histopathologically and radiologically confirmed nasolabial cyst between January 2010 and December 2017 were enrolled in this study.ResultsNasolabial cysts were predominant in females (91.7 per cent) and on the left side (54.2 per cent). Treatment involved an intraoral sublabial approach in 12 cases (48.0 per cent) and a transnasal endoscopic approach in 13 cases (52.0 per cent). In 13 cases (52.0 per cent) surgery was performed under local anaesthesia, while in 12 cases (48.0 per cent) it was conducted under general anaesthesia. The most common post-operative complications were numbness of the upper lip or teeth (n = 9, 36.0 per cent). Only one patient (4.0 per cent), who underwent a transnasal endoscopic approach, experienced a reoccurrence.ConclusionSurgical resection through an intraoral sublabial or transnasal endoscopic approach is the best treatment for a nasolabial cyst, showing very good results and a low recurrence rate. The recent surgical trend in our hospital is to treat nasolabial cysts using a transnasal endoscopic approach under local anaesthesia.
Time-dependent cognitive and somatic symptoms of depression as predictors of new cardiac-related events in at-risk patients: the UPBEAT-UK cohort
Authors: Norton J. , Pastore M. , Ancelin M. , Hotopf M. , Tylee A. , Mann A. , Palacios J. 
Published: January 2020

AbstractBackgroundEvidence suggests that somatic rather than cognitive depressive symptoms are risk factors for recurrent cardiac events in at-risk patients. However, this has never been explored using a time-dependent approach in a narrow time-frame, allowing a cardiac event-free time-window.MethodsThe analysis was performed on 595 participants [70.6% male, median age 72 (27–98)] drawn from the UPBEAT-UK heart disease patient cohort with 6-monthly follow-ups over 3 years. Depressive symptomatology was measured using the Patient Health Questionnaire-9 (PHQ-9) (four somatic, five cognitive items). New cardiac events (NCEs) including cardiac-related mortality were identified by expert examination of patient records. Analyses were performed using Cox proportional hazard models with delayed entry, with time-dependent depressive dimensions and covariates measured 12–18 months (median: 14.1, IQR: 3.5) prior to the event, with a 12-month cardiac event-free gap.ResultsThere were 95 NCEs during the follow-up [median time-to-event from baseline: 22.3 months (IQR: 13.4)]. Both the somatic (HR 1.12, 95% CI 1.05–1.20, p = 0.001) and cognitive dimensions (HR 1.11, 95% CI 1.03–1.18, p = 0.004) were time-dependent risk factors for an NCE in the multi-adjusted models. Specific symptoms (poor appetite/overeating for the somatic dimension, hopelessness and feeling like a failure for the cognitive dimension) were also significantly associated.ConclusionThis is the first study of the association between depressive symptom dimensions and NCEs in at-risk patients using a time-to-event standardised approach. Both dimensions considered apart were independent predictors of an NCE, along with specific items, suggesting regular assessments and tailored interventions targeting specific depressive symptoms may help to prevent NCEs in at-risk populations.
Distinct neural networks associated with obsession and delusion: a connectome-wide association study
Authors: Lee Tae Young , Jung Wi Hoon , Kwak Yoo Bin , Yoon Youngwoo B. , Lee Junhee , Kim Minah , Kim Euitae , Kwon Jun Soo 
Published: January 2020

AbstractBackgroundObsession and delusion are theoretically distinct from each other in terms of reality testing. Despite such phenomenological distinction, no extant studies have examined the identification of common and distinct neural correlates of obsession and delusion by employing biologically grounded methods. Here, we investigated dimensional effects of obsession and delusion spanning across the traditional diagnostic boundaries reflected upon the resting-state functional connectivity (RSFC) using connectome-wide association studies (CWAS).MethodsOur study sample comprised of 96 patients with obsessive–compulsive disorder, 75 patients with schizophrenia, and 65 healthy controls. A connectome-wide analysis was conducted to examine the relationship between obsession and delusion severity and RFSC using multivariate distance-based matrix regression.ResultsObsession was associated with the supplementary motor area, precentral gyrus, and superior parietal lobule, while delusion was associated with the precuneus. Follow-up seed-based RSFC and modularity analyses revealed that obsession was related to aberrant inter-network connectivity strength. Additional inter-network analyses demonstrated the association between obsession severity and inter-network connectivity between the frontoparietal control network and the dorsal attention network.ConclusionsOur CWAS study based on the Research Domain Criteria (RDoC) provides novel evidence for the circuit-level functional dysconnectivity associated with obsession and delusion severity across diagnostic boundaries. Further refinement and accumulation of biomarkers from studies embedded within the RDoC framework would provide useful information in treating individuals who have some obsession or delusion symptoms but cannot be identified by the category of clinical symptoms alone.
Using evolutionary algorithms to select text features for mining design rationale
Authors: Lester Miriam , Guerrero Miguel , Burge Janet 
Published: January 2020

AbstractAt its heart, design is a decision-making process. These decisions, and the reasons for making them, comprise the design rationale (DR) for the designed artifact. If available, DR provides a comprehensive record of the reasoning behind the decisions made during the design. Unfortunately, while this information is potentially quite valuable, it is usually not explicitly captured. Instead, it is often buried in other design and development artifacts. In this paper, we study how to identify rationale from text documents, specifically software bug reports and design discussion transcripts. The method we examined is statistical text mining where a model is built to use document features to classify sentences. Choosing which features are most likely to be good predictors is important. We studied two evolutionary algorithms to optimize feature selection – ant colony optimization and genetic algorithms. We found that for many types of rationale, models built with an optimized feature set outperformed those built using all the document features.
The 3‐D Thermal Structure of the Helvetic Nappes of the European Alps: Implications for Collisional Processes
Authors: Girault J. B. , Bellahsen N. , Boutoux A. , Rosenberg C. L. , Nanni U. , Verlaguet A. , Beyssac O. 
Published: January 2020

AbstractUnderstanding the rheology of orogenic wedges requires the knowledge of the structural and thermal evolution of collisional units. In this study, we document the maximum temperature reached by the sedimentary cover nappes of the External Crystalline Massif (Western and central Alps) by Raman spectroscopy of carbonaceous material, between the Belledonne (France) and the Aar (Switzerland) Massifs. These cover units form the Helvetic/Dauphinois nappe complex. Maximum temperatures reached by the Upper Helvetic nappes lie in a range spanning from below 220 and 350 °C ± 50 °C. For the Lower Helvetic nappes, the temperatures spread between 226 and 358 °C ± 50 °C. These temperatures were projected on two structural cross sections in order to constrain the 3‐D thermal structure. From these data, we propose that the Helvetic nappes were deformed and emplaced before and/or during the thermal peak, which supports recent findings that shortening in the External Crystalline Massif was mainly accommodated during a 5‐ to 10‐Myr‐long thermal peak before deformation localized along crustal thrusts, which exhumed and cooled down the wedge. During this late exhumation, the isotherms corresponding to the thermal peak were passively folded.
Global Change Can Make Coastal Eutrophication Control in China More Difficult
Authors: Wang Mengru , Kroeze Carolien , Strokal Maryna , van Vliet Michelle T. H. , Ma Lin 
Published: January 2020

AbstractFast socio‐economic development in agriculture and urbanization resulted in increasing nutrient export by rivers, causing coastal eutrophication in China. In addition, climate change may affect hydrology, and as a result, nutrient flows from land to sea. This study aims at a better understanding of how future socio‐economic and climatic changes may affect coastal eutrophication in China. We modeled river export of total dissolved nitrogen (TDN) and phosphorus (TDP) in 2050 for six scenarios combining socio‐economic pathways (SSPs) and Representative Concentration Pathways (RCPs). We used the newly developed MARINA 2.0 (Model to Assess River Inputs of Nutrients to seAs) model. We found that global change can make coastal eutrophication control in China more difficult. In 2050 coastal waters may be considerably more polluted or considerably cleaner than today depending on the SSP‐RCP scenarios. By 2050, river export of TDN and TDP is 52% and 56% higher than in 2012, respectively, in SSP3‐RCP8.5 (assuming large challenges for sustainable socio‐economic development, and severe climate change). In contrast, river export of nutrients could be 56% (TDN) and 85% (TDP) lower in 2050 than in 2012 in SSP1‐RCP2.6 (assuming sustainable socio‐economic development, and low climate change). Climate change alone may increase river export of nutrients considerably through hydrology: We calculate 24% higher river export of TDN and 16% higher TDP for the SSP2 scenario assuming severe climate change compared to the same scenario with low climate change (SSP2‐RCP8.5 vs. SSP2‐RCP2.6). Policies and relevant technologies combining improved nutrient management and climate mitigation may help to improve water quality in rivers and coastal waters of China.
Reevaluation of Perchlorate in Gale Crater Rocks Suggests Geologically Recent Perchlorate Addition
Authors: Martin Peter E. , Farley Kenneth A. , Douglas Archer P. , Hogancamp Joanna V. , Siebach Kirsten L. , Grotzinger John P. , McLennan Scott M. 
Published: January 2020

AbstractPerchlorate (ClO4−) was discovered in Martian soil by the Phoenix lander, with important implications for potential Martian biology, photochemistry, aqueous chemistry, and the chlorine cycle on Mars. Perchlorate was subsequently reported in both loose sediment and bedrock samples analyzed by the Sample Analysis at Mars instrument onboard the Curiosity rover in Gale crater based on a release of O2 at 200–500°C. However, the continually wet paleoenvironment recorded by the sedimentary rocks in Gale crater was not conducive to the deposition of highly soluble salts. Furthermore, the preservation of ancient perchlorate to the modern day is unexpected due to its low thermodynamic stability and radiolytic decomposition associated with its long exposure to radioactivity and cosmic radiation. We therefore investigate alternative sources of O2 in Sample Analysis at Mars analyses including superoxides, sulfates, nitrate, and nanophase iron and manganese oxides. Geochemical evidence and oxygen release patterns observed by Curiosity are inconsistent with each of these alternatives. We conclude that perchlorate is indeed the most likely source of the detected O2 release at 200–500°C, but contend that it is unlikely to be ancient. Rather than being associated with the lacustrine or early diagenetic environment, the most likely origin of perchlorate in the bedrock is late stage addition by downward percolation of water through rock pore space during transient wetting events in the Amazonian. The conclusion that the observed perchlorate in Gale crater is most likely Amazonian suggests the presence of recent liquid water at the modern surface.
Identification and Description of a Silicic Volcaniclastic Layer in Gale Crater, Mars, Using Active Neutron Interrogation
Authors: Czarnecki S. , Hardgrove C. , Gasda P. J. , Gabriel T. S. J. , Starr M. , Rice M. S. , Frydenvang J. , Wiens R. C. , Rapin W. , Nikiforov S. , Lisov D. , Litvak M. , Calef F. , Gengl H. , Newsom H. , Thompson L. , Nowicki S. 
Published: January 2020

AbstractThe Dynamic Albedo of Neutrons instrument aboard the Mars Science Laboratory rover, Curiosity, has been used to map a stratigraphically conformable layer of high‐SiO
material in Gale crater. Previous work has shown that this material contains tridymite, a high‐temperature/low‐pressure felsic mineral, interpreted to have a volcanic source rock. We describe several characteristics including orientation, extent, hydration, and geochemistry, consistent with a volcaniclastic material conformably deposited within a lacustrine mudstone succession. Relationships with widely dispersed alteration features and orbital detections of hydrated SiO
suggest that this high‐SiO
layer extends at least 17 km laterally. Mineralogical abundances previously reported for this high‐SiO
material indicated that hydrous species were restricted to the amorphous (non‐crystalline) fraction, which is dominated by SiO
. The low mean bulk hydration of this high‐SiO
layer (1.85
0.13 wt.% water‐equivalent hydrogen) is consistent with silicic glass in addition to opal‐A and opal‐CT. Persistent volcanic glass and tridymite in addition to opal in an ancient sedimentary unit indicates that the conversion to more ordered forms of crystalline SiO
has not proceeded to completion and that this material has had only limited exposure to water since it originally erupted, despite having been transported in a fluviolacustrine system. Our results, including the conformable nature, large areal extent, and presence of volcanic glass, indicate that this high‐SiO
material is derived from the product of evolved magma on Mars. This is the first identification of a silicic volcaniclastic layer on another planet and has important implications for magma evolution mechanisms on single‐plate planets.
Directional Climate Trend, Intensified Intraannual Variability, and Changes in Land Cover Drive the Dynamics of Vegetation Greenness in Peri‐Urban China During 2001–2015
Authors: Gao Q. , Yu M. , Xu H. 
Published: January 2020

AbstractSpatiotemporal dynamics of remote‐sensed vegetation indices and derived variables such as land surface phenology have often been studied as a function of climate with implied assumption of negligible land‐cover change. However, this assumption is not valid for areas with intensive human activities such as fast‐developing countries. To address the impact of land cover on vegetation greenness, we analyzed the trend of EVI59, enhanced vegetation index in May–September, within the 25‐km2 patches centered at 674 meteorological stations located mostly in peri‐urban areas of China, and the impacts of land cover and intraannual climate variability on the EVI, during 2001–2015 by means of linear mixed‐effect model. Impacts of land cover were assessed with the enhancement of sum of the squared difference with respect to the climate model. The climate models explained on average 60% sum of the squared difference of the full models (climate plus land cover), and this proportion reached 83% and 94% for the temperate grassland and the high‐cold Tibet, respectively. Including land cover enhanced on average 40% of the sum of the squared difference, and the enhancement is over 60% for the dense‐populated warm‐temperate‐deciduous forest and subtropical‐evergreen forest zones. The impact of land cover not only depends on the intensity but also on the type of land‐cover change. Forest regrowth in east China and vegetation growth from bare land in temperate desert significantly enhanced greenness but the shift from agriculture to shrubs in temperate grassland may not significantly alter the greenness. We showed that climate variability is important for EVI in all zones except Tibet, and the climate variability contributed on average 64% of climate impacts.
Timing, Kinematics, and Displacement of the Taltal Fault System, Northern Chile: Implications for the Cretaceous Tectonic Evolution of the Andean Margin
Authors: Mavor S. P. , Singleton J. S. , Gomila R. , Heuser G. , Seymour N. M. , Williams S. A. , Arancibia G. , Johnston S. M. , Kylander‐Clark A. R. C. , Stockli D. F. 
Published: January 2020

AbstractAn extensive system of NW striking faults constitutes a major tectonic feature of the Coastal Cordillera in northern Chile, but fundamental questions remain about timing and kinematics of these structures. We present new geologic mapping and geochronology that provide insight into the structural evolution and tectonic significance of the Taltal fault system (TFS). The TFS displaces the Early Cretaceous arc‐parallel Atacama fault system (AFS) with ~10.6 km cumulative offset across a ~15 km wide zone. Brittle fault data demonstrate that the TFS is vertical to steeply NE dipping with an average sinistral slip vector plunging 11° from the NW, compatible with E‐W shortening. Two late Early Cretaceous dikes cut the AFS but are cut by TFS faults, and synkinematic calcite on a TFS strand yielded a U‐Pb calcite date of 114.1 ± 7.0 Ma. These data demonstrate that the AFS was abandoned and deformation (re) initiated on the TFS between ~114–107 Ma, with continued slip after intrusion of the Tropezón (~110 Ma) and Librillo (106–101 Ma) plutonic complexes. Emplacement of a ~146 Ma rhyolite dike along the main Taltal fault and 141 ± 11 Ma calcite mineralization in the fault core suggests that a precursor structure influenced magma emplacement and fluid flow in the Late Jurassic/Early Cretaceous, supporting the hypothesis that the TFS reactivated long‐lived inherited crustal weaknesses. The Early Cretaceous shift from arc‐parallel shear to slip on the TFS and E‐W shortening shortly preceded migration of the magmatic arc and records a change in the Chilean margin subduction dynamics.
Adaptive Multirate Mass Transfer (aMMT) Model: A New Approach to Upscale Regional‐Scale Transport Under Transient Flow Conditions
Authors: Guo Zhilin , Henri Christopher V. , Fogg Graham E. , Zhang Yong , Zheng Chunmiao 
Published: January 2020

AbstractThe long‐term evaluation of regional‐scale groundwater quality needs efficient upscaling methods for transient flow. Upscaling techniques, such as the Multirate Mass Transfer (MRMT) method with constant upscaling parameters, have been used for transport with steady‐state flow, yet the upscaling parameters (i.e., rate coefficients) may be time dependent. This study proposed and validated an adaptive MRMT (aMMT) method by allowing the mass transfer coefficients in MRMT to change with the flow field. Advective‐dispersive contaminant transport simulated in a 3‐D heterogeneous medium was used as a reference solution. Equivalent transport under homogeneous flow conditions was evaluated by applying the MRMT and aMMT models for upscaling. The relationship between mass transfer coefficients and flow rates was fitted under steady‐state flow driven by various hydraulic gradients. A power law relationship was obtained, which was then used to update the mass transfer coefficients in each stress period under transient flow conditions in the aMMT method. Results indicated that for advection‐dominated transport, both the MRMT and aMMT methods can upscale the anomalous transport dynamics affected by subgrid heterogeneity under transient flow conditions. Whereas for diffusion‐dominated systems, the MRMT model failed to capture the tails of tracer breakthrough curves after the boundary condition changed, but the results from the aMMT model were significantly improved. However, if the overall flow direction changed, both MRMT and aMMT failed to represent the breakthrough curve tail generated by the heterogeneous system. The results point toward a promising path for upscaling transport in complex aquifers with transient flow.
ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma
Authors: Andersson Mattias K. , Mangiapane Giovanna , Nevado Paloma Tejera , Tsakaneli Alexia , Carlsson Therese , Corda Gabriele , Nieddu Valentina , Abrahamian Carla , Chayka Olesya , Rai Lilam , Wick Michael , Kedaigle Amanda , Stenman Göran , Sala Arturo 
Published: January 2020

AbstractAdenoid cystic carcinoma (ACC) is a rare cancer that preferentially occurs in the head and neck, breast, as well as in other sites. It is an aggressive cancer with high rates of recurrence and distant metastasis. Patients with advanced disease are generally incurable due to the lack of effective systemic therapies. Activation of the master transcriptional regulator MYB is the genomic hallmark of ACC. MYB activation occurs through chromosomal translocation, copy number gain or enhancer hijacking, and is the key driving event in the pathogenesis of ACC. However, the functional consequences of alternative mechanisms of MYB activation are still uncertain. Here, we show that overexpression of MYB or MYB-NFIB fusions leads to transformation of human glandular epithelial cells in vitro and results in analogous cellular and molecular consequences. MYB and MYB-NFIB expression led to increased cell proliferation and upregulation of genes involved in cell cycle control, DNA replication, and DNA repair. Notably, we identified the DNA-damage sensor kinase ATR, as a MYB downstream therapeutic target that is overexpressed in primary ACCs and ACC patient-derived xenografts (PDXs). Treatment with the clinical ATR kinase inhibitor VX-970 induced apoptosis in MYB-positive ACC cells and growth inhibition in ACC PDXs. To our knowledge, ATR is the first example of an actionable target downstream of MYB that could be further exploited for therapeutic opportunities in ACC patients. Our findings may also have implications for other types of neoplasms with activation of the MYB oncogene.
Lipoxin A4 suppresses angiotensin II type 1 receptor autoantibody in preeclampsia via modulating caspase-1
Authors: Liu Haojing , Cheng Fangxiong , Xu Qiang , Huang Wei , Wang Sumei , Sun Rui , Ye Duyun , Zhang Dongxin 
Published: January 2020

AbstractPreeclampsia (PE) remains a leading cause of maternal and neonatal morbidity and mortality. Numerous studies have shown that women with PE develop autoantibody, termed angiotensin II type 1 receptor autoantibody (AT1-AA), and key features of the disease result from it. Emerging evidence has indicated that inflammatory cell necrosis, such as pyroptosis, could lead to autoantigen exposure and stimulate autoantibody production. Caspase-1, the central enzyme of inflammasome and key target of pyroptosis, may play roles in AT1R exposure and AT1-AA production. Exploring endogenous regulator that could inhibit AT1-AA production by targeting pyroptosis will be essential for treating PE. Lipoxin A4 (LXA4), endogenous dual anti-inflammatory and proresolving lipid mediator, may inhibit AT1-AA production via modulating caspase-1. Thus, we explore whether caspase-1 is essential for AT1-AA production and LXA4 inhibits AT1-AA via modulating caspase-1. PE patients and mice developed AT1-AA associated with caspase-1 activation. Caspase-1 deletion leaded to AT1-AA decrease in PE mice. Consistent with these findings, we confirmed caspase-1 activation, trophoblast pyroptosis and AT1R exposure in PE mice and trophoblast model, while caspase-1 deficiency showed decreased trophoblast pyroptosis and AT1R exposure in vitro and in vivo. Interestingly, LXA4 could suppress AT1-AA production via regulating caspase-1 as well as enhancing phagocytosis of dead trophoblasts by macrophages. These results suggest that caspase-1 promotes AT1-AA production via inducing trophoblast pyroptosis and AT1R exposure, while LXA4 suppresses AT1-AA production via modulating caspase-1, supporting caspase-1 serving as a therapeutic target for attenuating AT1-AA and LXA4 protecting patients from AT1-AA and PE.