bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pacing Behavior Development of Youth Short-Track Speed Skaters: A Longitudinal Study
Authors: MENTING STEIN GERRIT PAUL , HUIJGEN BARBARA CATHARINA , KONINGS MARCO JOHANNES , HETTINGA FLORENTINA JOHANNA , ELFERINK-GEMSER MARIJE TITIA 
Published: December 2019

ABSTRACT

Purpose
This study aimed to analyze the development of pacing behavior of athletes during adolescence using a longitudinal design.

Methods
Lap times of male short-track speed skaters (140 skaters, 573 race performances) over two or more 1500-m races during Junior World Championships between 2010 and 2018 were analyzed. Races were divided into four sections (laps 1–3, 4–7, 8–11, and 12–14). Using MLwiN (P < 0.05), multilevel prediction models in which repeated measures (level 1) were nested within individual athletes (level 2) were used to analyze the effect of age (15–20 yr), race type (fast, slow), and stage of competition (final, nonfinal) on absolute section times and relative section times (percentage of total time spent in a section).

Results
Between the ages of 15 and 20 yr, total race time decreased (−6.99 s) and skaters reached lower absolute section time in laps 8–11 (−2.33 s) and 12–14 (−3.28 s). The relative section times of laps 1–3 (1.42%) and 4–7 (0.66%) increased and of laps 8–11 (−0.53%) and 12–14 (−1.54%) decreased with age. Fast races were more evenly paced compared with slow races, with slow races having a predominantly slow first half and fast finish. Athletes in finals were faster (2.29 s), specifically in laps 4–7 (0.85 s) and laps 8–11 (0.84 s).

Conclusion
Throughout adolescence, short-track speed skaters develop more conservative pacing behavior, reserving energy during the start of the race in order to achieve a higher velocity in the final section of the race and a decrease in total race time. Coaches should take into consideration that the pacing behavior of young athletes develops during adolescence, prepare athletes for the differences in velocity distribution between race types, and inform them on how to best distribute their efforts over the different stages of competition.
CUIDADO COM PACIENTES E FAMÍLIAS QUE VIVENCIAM O PROCESSO DE MORTE: REPRESENTAÇÕES SOCIAIS DO ENFERMEIRO
Authors: Gois Amanda Regina da Silva , Abrão Fatima Maria da Silva , França Inacia SatiroXavier 
Published: December 2019

Introdução: Enfermeiros cuidam da pessoa, família e coletividade, sendo assim, quando o sujeito inicia a vivencia do processo de morte a família também passa a ser alvo cuidar desses profissionais. Objetivo: Compreender e analisar as representações sociais dos enfermeiros sobre o cuidado com pacientes e famílias que vivenciam o processo de morte. Materiais e Métodos: Trata-se de estudo de campo, exploratório, qualitativo de representações sociais. Realizado em unidades oncológicas de um hospital universitário, vinte um enfermeiros foram entrevistados, estas passaram por análise de conteúdo temático-categorial. Resultados: Emergiram da análise das falas, as seguintes unidades temáticas: 1) Cuidando do paciente em processo de morte; 2) Cuidando da família do paciente em processo de morte; 3) As relações e estratégias entre o enfermeiro, paciente e família diante do processo de morte; 4) Quando ou se é o seu familiar em processo de morte. Conclusão: O cuidado com a família do paciente em processo de morte é um desafio pelos diversos aspectos que envolvem. Destacando-se que a conversa, o diálogo, o respeito e o olhar introspectivo, podem mediar estas relações.
IDOSOS EM INSTITUIÇÃO DE LONGA PERMANÊNCIA E RELAÇÕES FAMILIARES
Authors: Cataneo Fernanda Monteiro , Cardozo Tuane Maiara , Monterrosa ayala Arlene laurenti 
Published: December 2019

Introdução: As condições de vida do idoso em instituições de longa permanência tem sido objeto de pesquisas visto à falta de suporte, sobretudo de natureza afetiva e de apoio familiar. Objetivo: Este estudo teve por objetivo conhecer as características socioeconômicas e de proximidade familiar dos idosos que vivem em uma instituição de longa permanência localizada em Joinville, Santa Catarina. Materiais e Métodos: Trata-se de um estudo descritivo de caráter exploratório que foi realizado com dez idosos. Os dados foram coletados por meio de um questionário semiestruturado. As variáveis investigadas consideraram as características socioeconômicas, aspectos relacionados à saúde, à família e a instituição de longa permanência. Resultados: A idade dos idosos variou entre 66 a mais de 80 anos. A maioria era do sexo masculino, possuía ensino médio completo e referiu problemas de saúde. O tempo de institucionalização dos idosos variou de 4 meses a 10 anos e motivo mais frequente para a institucionalização foi a dependência física. Mais da metade dos entrevistados tiveram resposta positivas sobre gostar de estar na Instituição de Longa Permanência. Conclusões: A institucionalização do idoso pode ser geradora de sofrimento, mas também pode constituir-se um ambiente de conformação de vínculos afetivos. O idoso atribui considerável importância aos cuidados, o que impõe aos profissionais uma atenção que abranja os vários aspectos da vida da pessoa envelhecida. Em razão do envelhecimento populacional, seria desejável que fossem realizados estudos que aprofundassem a analise de outros fatores que poderiam estar contribuindo para qualidade de vida dos idosos institucionalizados.
Decoupling and detecting angular motion errors based on a line laser sensor for motion platforms
Authors: Chen Cheng , Zhang Hongru , Chen Shaoxuan , Liu Bing , Zhang Kai , Ji Hongwei 
Published: December 2019

Efficient measurement of a line laser sensor can be achieved by
combining it with a multi-axis platform. However, the measuring
results are significantly affected by the precision of the platform.
To provide a criterion for verifying and compensating for the
geometric errors of a platform, a measuring method based on a line
laser sensor for angular motion errors is proposed for the first time
to the best of our knowledge in this work. The principles of
separating and simultaneously detecting the yaw, roll, and pitch
errors are elaborated. Based on this, the detection model is built for
a three-dimensional platform. Under such an experimental condition,
the stability and accuracy of the line laser sensor is tested, and the
experimental results revealed small deviations of 3 µm and 10 µm in

z

axis and

x

axis, respectively. Ultimately, a
series of experiments is performed to verify the feasibility and
repeatability of the method. The yaw experimental results indicate
that the trend and rule of error conform to the measured value by a
laser interferometer, and the maximum variation value is
0.0075 mrad.
Point-of-Care Testing in Microbiology: A Mechanism for Improving Patient Outcomes
Authors: Hansen Glen T 
Published: December 2019

AbstractBACKGROUNDIncreasingly, demands for improved health and quality of life conflict with the realities of delivering healthcare in an environment of higher expenditures, adherence to test utilization, and patient-centered experience. Patient-centered care is commonly identified as a goal of healthcare delivery, and yet healthcare systems struggle with delivery of care to patients, often failing to identify the seriously ill and capitalize on the predictive qualities of diagnostic testing. Point-of-care (POC) testing provides access to rapid diagnosis and predictive value key to realizing patient outcomes. An evaluation of cost-effective models and the clinical impact of POC testing for clinical microbiology is needed.CONTENTAccurate and rapid diagnostics have the potential to affect healthcare decisions to a degree well out of proportion to their cost. Contemporary healthcare models increasingly view POC testing as a mechanism for efficient deployment of healthcare. POC testing can deliver rapid diagnosis in environments where testing results can be used to direct management during patient visits and in areas where centralized laboratory testing may limit access to care. Nucleic acid assays, designed for POC testing, can match, or exceed, the sensitivity of conventional laboratory-based testing, eliminating the need for confirmation testing. Here, the goals of POC testing for microbiology, applications, and technologies, as well as outcomes and value propositions, are discussed.SUMMARYThe combination of rapid reporting, an increasing array of organisms capable of causing disease, actionable resulting, and improved patient outcomes is key in the evolution of POC testing in clinical microbiology.
Simultaneous Detection of Gene Fusions and Base Mutations in Cancer Tissue Biopsies by Sequencing Dual Nucleic Acid Templates in Unified Reaction
Authors: Song Zhengbo , Xu Chunwei , He Yunwei , Li Fugui , Wang Wenxian , Zhu Youcai , Gao Yanqiu , Ji Mingfang , Chen Miao , Lai Jiajia , Cheng Weimin , Benes Cyril H , Chen Li 
Published: December 2019

AbstractBACKGROUNDTargeted next-generation sequencing is a powerful method to comprehensively identify biomarkers for cancer. Starting material is currently either DNA or RNA for different variations, but splitting to 2 assays is burdensome and sometimes unpractical, causing delay or complete lack of detection of critical events, in particular, potent and targetable fusion events. An assay that analyzes both templates in a streamlined process is eagerly needed.METHODSWe developed a single-tube, dual-template assay and an integrated bioinformatics pipeline for relevant variant calling. RNA was used for fusion detection, whereas DNA was used for single-nucleotide variations (SNVs) and insertion and deletions (indels). The reaction chemistry featured barcoded adaptor ligation, multiplexed linear amplification, and multiplexed PCR for noise reduction and novel fusion detection. An auxiliary quality control assay was also developed.RESULTSIn a 1000-sample lung tumor cohort, we identified all major SNV/indel hotspots and fusions, as well as MET exon 14 skipping and several novel or rare fusions. The occurrence frequencies were in line with previous reports and were verified by Sanger sequencing. One noteworthy fusion event was HLA-DRB1-MET that constituted the second intergenic MET fusion ever detected in lung cancer.CONCLUSIONSThis method should benefit not only a majority of patients carrying core actionable targets but also those with rare variations. Future extension of this assay to RNA expression and DNA copy number profiling of target genes such as programmed death-ligand 1 may provide additional biomarkers for immune checkpoint therapies.
Poststroke Constipation Is Associated With Impaired Rectal Sensation
Authors: Cheng Jiafei , Li Liangda , Xu Feng , Xu Yuemei , Lin Lin , Chen Jiande D. Z. 
Published: December 2019

OBJECTIVES:
Constipation is prevalent in individuals after stroke. However, the pathophysiological mechanisms of poststroke constipation remain unclear. This study was designed (i) to investigate the difference in anorectal motility and rectal sensation among stroke patients with constipation, stroke patients without constipation, and healthy controls (HC), (ii) to evaluate the impact of stroke sites on constipation and rectal sensation, (iii) to explore the role of autonomic functions, and (iv) to determine the independent risk factors for poststroke constipation.

METHODS:
Seventy-one stroke patients and 24 HC were recruited. General information, clinical characteristics, and relevant questionnaires were collected. Meanwhile, an anorectal manometry test was performed to assess functions of anorectal motility and rectal sensation, and an electrocardiogram was recorded to evaluate autonomic functions.

RESULTS:
(i) Constipation patients exhibited increased rectal sensation thresholds, compared with patients without constipation or HC (P < 0.001). Almost no difference was detected in anorectal motility parameters among 3 groups. Constipation-associated clinical characteristics, such as spontaneous bowel movements, were weakly or moderately correlated with rectal sensation thresholds (P < 0.05 to P < 0.001 for various parameters). (ii) Patients with brainstem lesions had increased prevalence of constipation and first sensation threshold, compared with patients without brainstem lesions (P = 0.045, P = 0.025, respectively). (iii) There was a weak positive correlation between sympathetic activity and stroke severity and a weak negative one between vagal activity and stroke severity. Rectal sensation thresholds were positively and weakly correlated with sympathetic activity but negatively with vagal activity. (iv) The desire of defecation threshold and the physical activity were independent risk factors for poststroke constipation (P = 0.043, P = 0.025, respectively).

DISCUSSION:
Poststroke constipation is characterized by elevated thresholds for rectal sensation, rather than altered anorectal motility. Patients with brainstem lesions are predisposed to constipation possibly because of the disruption of afferent pathway from the rectum to the brain. Moreover, the desire of defecation threshold and the physical activity level are factors independently associated with poststroke constipation.
Composite Neuroendocrine and Squamous Cell Tumor of the Esophagus
Authors: Dasari Chandra S. , Ozlem Ulusarac , Kohli Divyanshoo R. 
Published: December 2019

ABSTRACT
Neuroendocrine cell tumors of the esophagus are rare forms of cancer. Incidence of squamous cell cancer of the esophagus is low in the United States. Combined tumors with components of both neuroendocrine and squamous cell cancer which are very rarely seen have not been reported in the United States. We present a unique case of a composite tumor of the esophagus with squamous cell carcinoma and neuroendocrine carcinoma.
Qatar Digital Library: A New Phase of Digital Archives
Authors: Al-Mutawa Maryam Ahmed 
Published: December 2019

Abstract
Qatar Digital Library is a collaboration project by Qatar Foundation and the British Library to have an open access digital archive which aims to benefit people around the world. QDL offers cultural and historical materials of the Gulf and other regions and make it available online for everyone. The aim of QDL is to improve the understanding of the Islamic world, Arab cultural heritage, and the modern history of the Gulf for the public and the academic researchers.
Unsere Bibliothek unter zwei Dächern
Authors: Becker Tom , Büchel Claudia 
Published: December 2019

Zusammenfassung
Wie können zwei Stadtbibliotheken im Bergischen Land so fusionieren, dass sie – trotz schwieriger Finanzbedingungen der Städte – erhalten bleiben, sich dabei gegenseitig unterstützen und ergänzen? Dieser herausfordernden Aufgabe stellte sich eine Gruppe Master-Studierender (MALIS) der TH Köln in einem Praxisprojekt zur strategischen Positionierung Öffentlicher Bibliotheken im Sommersemester 2018 und erarbeitete Handlungsempfehlungen, die Rahmenbedingungen beider Städte und Bibliotheken berücksichtigten.
Die Bibliothek des Landesmuseums für Kärnten – Kärntner Landesbibliothek
Authors: Janik Michael 
Published: December 2019

Zusammenfassung
Die Kärntner Landesbibliothek ist eine Informationseinrichtung im südlichsten Teil Österreichs, in Kärnten. Sie dient zur Literaturversorgung und Informationsvermittlung in unserem Bundesland. Der Sammlungsbestand umfasst ca. 150 000 Medieneinheiten, darunter 21 Inkunabeln. Besonderer Schwerpunkt liegt auf der Sammlung der Carinthiaca, also der Literatur aus und über Kärnten.
Generation Y – Y We Are Not the Ones You Think We Are!
Authors: Moßburger Luis , Gehring Tanja , Bärnreuther Karin , Bluhme Beatrice Iturralde , Rammler Christina 
Published: December 2019

Zusammenfassung
Die Generation Y ist immer wieder Anlass für Diskussionen, positiver und negativer Natur. Mit dem kommenden Generationenwechsel stellt sich die Frage, welche Auswirkungen dieser auf das Arbeiten in und die Identität von Bibliotheken hat. Dieser Artikel soll diese Frage beantworten, aus Sicht der Generation selbst und am Beispiel von aubib.de, einer neuen Plattform für das Bibliotheks- und Informationsmanagement in Bayern.
Erkennung von handschriftlichen Unterstreichungen in Alten Drucken
Authors: Gehrke Alexander , Balbach Nico , Rauch Yong-Mi , Degkwitz Andreas , Puppe Frank 
Published: December 2019

Zusammenfassung
Die Erkennung handschriftlicher Artefakte wie Unterstreichungen in Buchdrucken ermöglicht Rückschlüsse auf das Rezeptionsverhalten und die Provenienzgeschichte und wird auch für eine OCR benötigt. Dabei soll zwischen handschriftlichen Unterstreichungen und waagerechten Linien im Druck (z. B. Trennlinien usw.) unterschieden werden, da letztere nicht ausgezeichnet werden sollen. Im Beitrag wird ein Ansatz basierend auf einem auf Unterstreichungen trainierten Neuronalen Netz gemäß der U-Net Architektur vorgestellt, dessen Ergebnisse in einem zweiten Schritt mit heuristischen Regeln nachbearbeitet werden. Die Evaluationen zeigen, dass Unterstreichungen sehr gut erkannt werden, wenn bei der Binarisierung der Scans nicht zu viele Pixel der Unterstreichung wegen geringem Kontrast verloren gehen. Zukünftig sollen die Worte oberhalb der Unterstreichung mit OCR transkribiert werden und auch andere Artefakte wie handschriftliche Notizen in alten Drucken erkannt werden.
The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy
Authors: Muratoglu Sahin Nursel , Peltek Kendirci Havva Nur , Çetinkaya Semra , Savaş Erdeve Şenay , Aycan Zehra 
Published: December 2019

AbstractBackgroundSome studies have examined the effect of gonadal suppression on insulin-like growth factor-1 (IGF-1) levels and the growth velocity (GV) with conflicting results.MethodsForty-four girls treated with gonadotropin-releasing hormone analogue (GnRHa) for central precocious puberty (CPP) were included in the study. IGF-1 levels were examined at the beginning and after 12 months of treatment.ResultsIGF-1 and IGF-1 standard deviation score (SDS) according to chronological age (CA-IGF-1 SDS) at diagnosis were positively correlated with chronological age (CA), anthropometric measurements, stage of puberty, bone age (BA), BA-CA, follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, uterus length, endometrium thickness and ovarian volume (OV) at diagnosis (p < 0.05). There was no significant difference in IGF-1 levels after treatment. However, there was a negative correlation between ΔIGF-1 SDS and IGF-1 level, CA-IGF-1 SDS and BA-IGF-1 SDS at diagnosis (p < 0.05). There was no correlation between GV and IGF-1, ΔIGF-1. GV was negatively correlated with basal LH level at diagnosis (p = 0.008, r = −0.397). Peak LH levels of the patients who had GV-SDS < 0 were more suppressive than those of the patients who had GV-SDS > 0 after 12 months of treatment.ConclusionsIt was determined that the IGF-1 level and CA-IGF-1 SDS at baseline were correlated with more advanced pubertal stage prior to treatment. Initiation of treatment with a relatively high level of IGF-1 increased the risk of a decrease in the IGF-1 level. Likewise, the initiation of treatment with a relatively high LH level may increase the risk of low GV, but low GV was not related to the IGF-1 level. Increased sex steroid suppression may increase the risk of low GV.
Clinical findings in five Turkish patients with citrin deficiency and identification of a novel mutation on SLC25A13
Authors: Köse Melis Demir , Kagnici Mehtap , Özdemir Taha Reşit , Erdur Cahit Barış , Erdemir Gülin , Karakoyun Miray , Guzin Yiğit , Ceylaner Serdar , Genel Ferah 
Published: December 2019

Abstract

Background
Citrin deficiency (CD) is an autosomal recessive genetic disorder caused by a defect in the mitochondrial aspartate/glutamate antiporter, citrin. Three clinical manifestations have been described until today.

Case presentation
We reported 5 CD patients from two families. Four patients were male and one patient was female. Two of them have NICCD (neonatal intrahepatic cholestasis caused by citrin deficiency); three of them have CTLN2 (adult-onset type II citrullinemia). Both NICCD patients showed typical clinical and biochemical changes with a diagnosis confirmed by mutations in the SLC25A13 gene. We detected a previously unreported homozygous novel mutation c.478delC (L160Wfs*36 ) on the SLC25A13 gene. All of the CTLN2 patients were siblings. Proband was a 15-year-old mentally retarded and autistic male who had admitted to our emergency with disorientation. Laboratory data showed hyperammonemia and citrullinemia.

Conclusions
Two different profiles of age-related CD have been depicted with this article. It has been aimed to underline that the CD can be observed in different forms not only in neonatals or little infants but also in adolescents. This article is the first case series that covers both NICCD and CTLN2 cases together and that has been published in Turkey. Considering the fact that especially the majority of CTLN2 cases have been identified in Asian countries, our article has vital importance in terms of defining phenotypic features of the disease.
Schilddrüsenerkrankungen: Diagnostik und Therapiekontrolle 2015
Authors: Führer Dagmar 
Published: December 2019

Zusammenfassung:
In dieser Übersicht werden Studien und evidenzbasierte Behandlungsempfehlungen zu Schilddrüsenerkrankungen zusammengefasst. Im Einzelnen handelt es sich um Diagnostik und Therapie des Morbus Basedow einschließlich der endokrinen Orbitopathie, die laborchemische und klinische Definition einer hypothyreoten Stoffwechsellage und Besonderheiten der Hypothyreosetherapie, sowie um Neuerungen zur Risikoeinschätzung bei Schilddrüsenknoten und zur Behandlung von Schilddrüsenkarzinomen.
Automation in biobanking from a laboratory medicine perspective
Authors: Baber Ronny , Kiehntopf Michael 
Published: December 2019

Abstract
Biobanks are important infrastructures to support clinical research and developments in personalized medicine. Although biobanking is not a new invention it has gained importance in the last few years due to increased quality requirements for biological samples in biomedical research and new high resolution Omics-technologies. Moreover, quality-assured collection, processing and storage of biological samples with defined pre-analytical history plays a key role for reproducibility in scientific research and paves the path towards precision medicine. Due to the increasing need for large numbers of samples, both in basic as well as in translational research, particular attention must be paid to sample acquisition and preparation in order to guarantee the highest possible sample quality. This can be achieved by following best practices or implementation and operation of specific biobank quality management systems that are compliant with the new DIN EN ISO 20387. Moreover, automation of critical process steps in biobanking can help to reach the highest quality standard and consistent sample quality. The following article will present and discuss currently available solutions for process automation in biobanking.
The Multimodal Mediation of Knowledge: Instructors’ Explanations in a Scientific Café
Authors: Polo Claire , Colletta Jean-Marc 
Published: December 2019

Abstract
In this paper, we present an in depth study of the interplay between various semiotic modes in the specific instructional setting of a scientific café. We analyzed the multimodal performance of five female instructors delivering a monologue explanation during instruction on the following dimensions: speech, gesture (hand gestures, head orientation and gaze) and use of written didactical material. Results first point out the crucial role played by referential hand gesture together with gaze-body behavior both in representing new concepts (conceptual mediation) and in building bridges between information displayed in several modes (semiotic mediation). They also show cross-individual differences in instructors’ multimodal performance, that we propose to interpret as three diverse modes of mediating knowledge, guiding being the only one providing both conceptual and semiotic mediation.