bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Functional Outcomes of At-Risk Mental State Among Non-Help Seeking Adolescents
Authors: Švancer Patrik , Dorazilová Aneta , Voráčková Veronika , Knytl Pavel , Mohr Pavel , Rodriguez Mabel , Jonáš Juraj , Šebela Antonín 
Published: August 2020

Abstract
Background: At-risk mental state (ARMS) individuals are at high risk to develop psychosis. In addition to attenuated symptoms, ARMS is associated with cognitive and functional impairment. The findings are mostly based on research in help-seeking at-risk population. Our study aim was to explore prevalence rates of ARMS, comorbidities, functioning, and cognitive performance among non-help seeking adolescents. Patients and methods: Study subjects were randomly selected high school adolescents. At-risk mental state was assessed with Comprehensive Assessment of At Risk Mental States interview (CAARMS). Kiddie-Schedule for Affective Disorders and Schizophrenia examined comorbidities. Social functioning and quality of life were measured with Social and Occupational Functioning Assessment Scale (SOFAS) and KIDSCREEN 52. Cognitive performance in the domains of visual memory, verbal memory, working memory, and processing speed was assessed with a battery of cognitive tests Results: The total of 82 adolescents was enrolled, 21 of them met the ARMS criteria. No case of threshold psychotic disorder was detected in the study sample. Subthreshold mental disorders were more frequent in the ARMS+ group than in the ARMS- group (OR= 3.05; 95%CI 1.07, 8.67; p=0.03). Lower SOFAS scores were observed in the ARMS+ group compared to the ARMS- group (t= -3.888; p<.001; Cohen’s d = 0.99). In the total sample, CAARMS symptoms intensity was negatively associated with the SOFAS score (β = -.51; R2 = 0.26; p<.001). No significant differences in the KIDSCREEN-52 scores or cognitive functioning were found between the groups. Conclusion: Our findings suggest that non-help seeking adolescents with at-risk mental state have worse level of functioning compared to controls and higher rates of non-psychotic psychiatric comorbidities. Reduction in functioning is negatively associated with the severity of their subsyndromal psychotic symptoms.
Zuogui Jiangtang Jieyu Decoction&nbsp;Ameliorates Depression-Like Behavior in Diabetic Rats via Activation of Neuronal and Astrocytic IR/IRS-1 Signaling Pathway
Authors: Yang Hui , Ling Jia , Meng Pan , Liu Jian , Lin Xiaoyuan , Li Wei , Wang Yuhong 
Published: August 2020

Abstract
Background: Zuogui Jiangtang Jieyu decoction(ZJJ) is a Chinese herbal formulation on the strength of Zuogui Wan which recorded in the “Jing Yue Quan Shu” in the Ming dynasty. It is mainly used for treatment of diabetes-related depression in current clinical applications and researches. This study aims to investigate whether brain IR/IRS-1 signaling pathway involved in the therapeutic effect of ZJJ on depression-like behavior in diabetic rats.Methods: Sprague Dawley rats were fed with high fat diet, and subjected to streptozotocin injection to establish the diabetes animal model. After treatment with different doses of ZJJ (20.530 g/kg or 10.265 g/kg) for 4 weeks, blood glucose level and peripheral insulin resistance were measured. Forced-swimming test (FST) and Morris water maze test (MWMT) were applied for mood and cognitive function assessment. Then western blot was used to analyze the protein levels of insulin receptor (IR), insulin receptor substrate-1 (IRS-1), phosphatidylonositol-3-kinase (PI3K), and protein kinase B (AKT) in the hippocampus of diabetic rats. Meanwhile, immunofluorescence and double-labeling immunofluorescence were performed to analyze the above proteins expression in the neuron and astrocyte, respectively. At last, energy metabolism and glycogen metabolism were tested by using ELISA. Additionally, the insulin-sensitive glucose transporter 4 (GLUT4) and the lactate transporter monocarboxylate transporter 4 (MCT4) were analyzed by using western blot.Results: ZJJ administration significantly decreased blood glucose and improved peripheral insulin resistance of diabetic rats. Besides, ZJJ improved the depression-like behavior and cognitive dysfunction caused by diabetes. Furthermore, result of the western blot analysis showed that ZJJ treatment increased the expression of phospho-IR, phospho-IRS-1, phospho-PI3K, and phospho-AKT in the hippocampus of diabetic rat. Moreover, result of immunofluorescence showed that the above proteins were increased not only in the neuron but also in the astrocyte after ZJJ administration. In addition, ZJJ increased the content of ATP, glycogen and lactate, as well as the expression of GLUT4 and MCT4 in the hippocampus of diabetic rats.Conclusions: These findings suggested that ZJJ improves the depression-like behavior of diabetic rats by activating both neuronal and astrocytic IR/IRS-1 signaling pathway. And the brain IR/IRS-1 signaling pathway plays an important role in astrocyte-neuron metabolic coupling, providing a potential mechanism by which IR/IRS-1 signaling pathway may contribute to the treatment of ZJJ on diabetes related depression.
A reinvenção dos modos de ser, pensar e estar
Authors: Raposo Paulo 
Published: August 2020

Trata-se de uma resenha do livro Pandemia: COVID-19 e a reinvenção do comunismo, do filósofo sloveno Slavoj Žižek, cujo objetivo é analisar o atual cenário mundial com as múltiplas crises provocadas pelo novo coronavírus que assola o mundo indistintamente e, por conseguinte, põe em questão os modelos de organização social e política que o capitalismo impõe.
Colóquios filosóficos como meio de melhoria na aprendizagem em Filosofia para os alunos da primeira série do Ensino Médio
Authors: Aureliano Ana Cristina 
Published: August 2020

Este projeto busca oferecer mediação pedagógica aos alunos do 9º ano de um colégio da rede particular, afim de melhorar a apreensão do conceito em relação à política, tais como: conhecimento, ética e moral, nas primeiras séries do Ensino Médio na disciplina de filosofia. Para atender a este objetivo, foi elaborado como estratégia didática os Colóquios Filosóficos, por se tratar de um meio de desenvolver temas pré-definidos, com exposições, debates e busca de tomada de decisões. Foi realizado uma sondagem inicial para saber o qual o conhecimento prévio dos alunos do 9º ano sobre política, numa perspectiva filosófica, o planejamento dos colóquios com os palestrantes convidados, a realização dos colóquios, o monitoramento e a avaliação final. Trazendo como resultados o interesse dos alunos para participar dos colóquios, discussões e questionamentos, dando resposta a capacidade de apreensão de conteúdos sistemáticos da grade curricular do Ensino Médio de forma prazerosa e eficaz.
Recombinant Human p53 Adenovirus Injection (rAd-p53) Combined with Chemotherapy for 4 Cases of High-grade Serous Ovarian Cancer
Authors: Qu Hui , Xia Yu , Li Xiuqin 
Published: August 2020

Background:
High-grade serous ovarian carcinoma (HGSOC) is one of the most common
ovarian epithelial carcinomas. It is highly invasive, easily recurs after systemic treatment, and has a poor
prognosis. Despite many new chemotherapeutic drugs and trials of combinations of different regimens
that have been used in treatment attempts, there has been no meaningful progress in the treatment of
HGSOC. With the development of gene sequencing technology, gene therapy has become a new direction
for tumors treatment. It is reported that the P53 has a very high mutation rate in HGSOC, which provides
a theoretical basis for the application of gene therapy in HGSOC patients. Recombinant human p53
adenovirus injection (rAd-p53) is the world's first approved oncology gene therapy drug.

Case Report:
In this article, we retrospectively analyzed 4 cases of HGSOC patients treated with rAdp53.
Three of them were recurrent ovarian cancer, and one was the initial treatment. The treatment
method was to apply recombinant human p53 adenovirus injection (rAd-p53) to the lesions for local
injection, 72 hours later, the lesions were injected with bleomycin or fluorouracil, and systemic intravenous
chemotherapy was performed simultaneously. After rAd-p53 treatment, one of the three relapsed
ovarian cancers achieved complete remission(CR), one achieved partial remission (PR), and
one was stable disease (SD); the treatment-naive patient was operated after rAd-p53 combined with
neoadjuvant chemotherapy and achieved pathological CR. Under the action of various mechanisms of
P53, the subsequent tumor treatment showed the characteristics of slow tumor progression, no ascites,
and local recurrence. As of the end of follow-up, the OS of 4 patients was 71-120 months.

Conclusion:
Through the remarkable efficacy of these 4 cases, we can see that the application of rAdp53
combined with chemotherapy can effectively control tumor lesions, prolong the survival time of patients,
improve the quality of life of patients, which provide valuable experiences for rAd-p53 treatment
in ovarian cancer, promote the further development and progress of gene therapy in this field.
Microbleeds after Stent-assisted Coil Embolization of Unruptured Intracranial Aneurysms: Incidence, Risk Factors and the Role of Thromboelastography
Authors: Xu Rui , Cheng Chongjie , Wu Yue , Guo Zongduo , Sun Xiaochuan , Xia Yongzhi , Zhang Xiaodong 
Published: August 2020

Objective:
To analyze the incidence and risk factors of microbleeds lesions and to use
thromboelastography (TEG) to evaluate the relationship between perioperative platelet function
and microbleed events in patients with unruptured intracranial aneurysms (UIAs) undergoing
Stent-Assisted Coil (SAC) embolization.

Methods:
We retrospectively enrolled 261 patients with UIAs undergoing SAC embolization
between November 2017 and October 2019. All patients received unanimous antiplatelet protocol
(aspirin 300 mg and clopidogrel 300 mg). Platelet function was evaluated by TEG, and magnetic
resonance susceptibility-weighted imaging (SWI) was performed for microbleeds detection
before and after surgery. Univariate and multivariate logistic regression analyses were used to identify
potential risk factors for microbleeds following embolization.

Results:
Microbleed lesions were identified in 122 of 261 patients (46.7%). Most of the microbleeds
were asymptomatic, except for 22 patients complaining slight headaches, and 3 patients
who developed cerebral hemorrhage after discharge. Among the clinical characters, female, previous
intracerebral hemorrhage (ICH) history and TEG parameters variation (higher reaction time
(R) and lower maximum amplitude of adenosine diphosphate (MAADP)) were associated with microbleeds
occurrence. Subsequent multivariate analysis indicated that gender, hemorrhage history,
R, and MAADP were still independent risk factors of microbleeds. The R-value (>7.6 min) and
MAADP (<29.2 mm) were predictive values, yielding areas under the receiver operating curve
(ROC) of 0.76 (95% CI 0.70 to 0.82) and 0.89 (95% CI 0.86 to 0.93), respectively.

Conclusion:
The incidence of microbleeds may be high in UIA patients treated with SAC and dual
antiplatelet therapy. Lesions occurred more frequently in female patients and patients with ICH history.
Among the TEG parameters, the R-value and MAADP were predictors for microbleed events.
Aggregation of Region-based and Boundary-based Knowledge Biased Segmentation for Osteoporosis Detection from X-Ray, Dual X-Ray and CT Images
Authors: Menaka R. , Ramesh R. , Dhanagopal R. 
Published: August 2020

Background:
Osteoporosis is a term used to represent the reduced bone density, which
is caused by insufficient bone tissue production to balance the old bone tissue removal. Medical
Imaging procedures such as X-Ray, Dual X-Ray and Computed Tomography (CT) scans are used
widely in osteoporosis diagnosis. There are several existing procedures in practice to assist osteoporosis
diagnosis, which can operate using a single imaging method.

Objective:
The purpose of this proposed work is to introduce a framework to assist the diagnosis of
osteoporosis based on consenting all these X-Ray, Dual X-Ray and CT scan imaging techniques.
The proposed work named “Aggregation of Region-based and Boundary-based Knowledge biased
Segmentation for Osteoporosis Detection from X-Ray, Dual X-Ray and CT images” (ARBKSOD)
is the integration of three functional modules.

Methods:
Fuzzy Histogram Medical Image Classifier (FHMIC), Log-Gabor Transform based
ANN Training for osteoporosis detection (LGTAT) and Knowledge biased Osteoporosis Analyzer
(KOA).

Results:
Together, all these three modules make the proposed method ARBKSOD scored the maximum
accuracy of 93.11%, the highest precision value of 93.91% while processing the 6th image
batch, the highest sensitivity of 92.93%, the highest specificity of 93.79% is observed during the experiment
by ARBKSOD while processing the 6th image batch. The best average processing time of
10244 mS is achieved by ARBKSOD while processing the 7th image batch.

Conclusion:
Together, all these three modules make the proposed method ARBKSOD to produce
a better result.
Computer Simulation of the Effects of Contrast Protocols on Aortic Signal Intensity on Magnetic Resonance Angiograms
Authors: Higaki Toru , Nakamura Yuko , Tatsugami Fuminari , Fukumoto Wataru , Awai Kazuo 
Published: August 2020

Background:
While iodine-enhanced computed tomography has been studied, detailed
information on gadolinium-enhanced magnetic resonance imaging has not been reported.

Objective:
We evaluated the effects of different gadolinium contrast agent (Gd-CA) factors on the
enhancement of aortic magnetic resonance angiography (MRA) using computer simulation.

Methods:
We developed computer-simulation software that combines pharmacokinetic models and
tables; it converts the blood concentration of particular Gd-CAs into the signal intensity (SI). We simulated
aortic time-intensity curves (TIC) in our MRA study and compared the effect of the Gd--
CA volume, injection rate, and of different Gd-CAs on the TIC.

Results:
An increase in the Gd-CA volume from 14.0 to 28.0 ml increased maximal aortic intensity
1.11 times. Changing the injection rate from 1.0 to 2.8 ml/s increased it 1.10 times. The maximal
SI of gadoterate-meglumine and gadobutrol was 1.03 and 1.01 times, respectively, that of gadoteridol.

Conclusion:
In our computer-simulated MRA study, different Gd-CA factors resulted in no significant
difference in the maximal aortic SI.
Tylophora hirsuta (Wall.) Extracts Ameliorate Diabetes Associated with Inflammation in Alloxan-induced Diabetic Rats
Authors: Razzaque Faisal , Sharif Ali , Akhtar Bushra , Khan Humaira M. , Akhtar Muhammad F. , Zaib Maryam , Muhammad Abdullah , Sohail Kashif , Hamid Irfan , Qaisar Naeem 
Published: August 2020

Background:Tylophora hirsuta (Wall) has long been used as traditional medicine for the treatment of diabetes. The current study is designed to evaluate the anti-diabetic and anti-inflammatory activity of different extracts of aerial parts of Tylophora hirsuta.Methods:Sequential maceration was conducted to obtain extracts. Total phenolic contents were determined by the Folin-Ciocalteau method. The anti-oxidant activity was assessed by DPPH free radical scavenging assay. The extracts were tested for its inhibitory activity against α-amylase in-vitro. In-vivo anti-diabetic assay was conducted using alloxan-induced diabetic model and OGTT was conducted on normal rats. ELISA was used to determine the pro-inflammatory cytokines (TNF-α and IL-6). The polyphenolic composition of the extract was analyzed using an HPLC system.Results:Aqueous extract exhibited highest total phenolic contents (985.24± 3.82 mg GAE/100 g DW), antioxidant activity (IC50 = 786.70 ± 5.23 μg/mL), and alpha-amylase inhibition (IC50 =352.8 μg/mL). The aqueous extract of Tylophora hirsuta showed remarkable in-vivo anti-diabetic activity. Results were compared with standard drug glibenclamide. Alloxan induced diabetic mediated alterations in liver function enzymes, renal function determinants, and lipid parameters were significantly restored in aqueous extract treated diabetic rats. A significant reduction in pro-inflammatory cytokines (p<0.001) was observed when compared to the control group. HPLC analysis confirms the presence of quercetin, gallic acid, cinnamic acid, and p-coumaric acid.Conclusion:These results showed that Tylophora hirsuta possesses strong anti-diabetic and anti-inflammatory potentials and justify its folklore use for the management of diabetes.
Role of Nano-Sized Graphene Amine Reinforcements in Mechanical Properties of AA7076 Based MMCs
Authors: Patil Adarsh , Banapurmath Nagaraj R. , Hunashyal Anand M. , Meti Vinodkumar V. , Patil Arun Y. , Shettar Ashok S. 
Published: August 2020

Aims:
AA7076 is a well-defined alloy for its excellent physical and mechanical properties
such as high strength, toughness, and low density. To meet the requirements of the automobile and
aerospace industry, the properties of AA7076 alloy have to be improved by reinforcing nano-sized
graphene amine particles.

Objective:
The aim of this study is to synthesize and characterize the AA7076 alloy reinforced with
graphene nanofillers for different structural engineering applications.

Methods:
In this present work, nano-sized graphene amine particles were added and dispersed homogeneously
using a motorized stir casting technique. AA7076/graphene amine composites were prepared
by varying wt.% percent of graphene amine reinforcement particles (0.5, 0.75, 1, and 1.25 wt.%
(weight-percentage)).

Results:
The SEM micrographs reveal the homogeneous distribution of graphene amine reinforcements
along the grain boundaries of the AA7076 matrix material. The experimental test results
showed that with the addition of graphene amine reinforcements, the mechanical properties of the
AA7076/graphene amine composites improved as compared to the AA7076 matrix material.

Conclusion:
The composite with 1 wt.% graphene amine showed higher strength and hardness as
compared to other reinforcements.
Effect of Choline Acetate on the Yeast Cells During Fermentation: Kinetics Approach
Authors: Elgharbawy Amal A. , Alam Md. Zahangir , Moniruzzaman Muhammad , Kabbashi Nassereldeen A. , Jamal Parveen , Motlagh Shiva R. 
Published: August 2020

Background:
Ionic liquids (ILs) are claimed as green solvents and have demonstrated ability
in the dissolution of several biomaterials and polymers, thus promoting their applications in wide
scope. The aim of this study was to evaluate the yeast cells in the ionic liquid (IL), choline acetate
[Cho]OAc as an eco-friendlier IL for their growth and ability of fermentation of the empty fruit bunch
(EFB) biomass for ethanol production via monitoring the cell growth curve and kinetics.

Methods:
The Saccharomyces cerevisiae was cultured for five days on yeast extract-peptone-dextrose
(YPD) agar and the sub-culturing was carried out every two weeks to evaluate the growth of yeast in
[Cho]OAc at different concentrations; 5%, 10%, and 20%, where it was pre-cultivated for 24 h at
30 °C and 150 rpm in a shaking incubator as a control culture. Yeast cell number was determined by
counting using a hemocytometer. Also, the kinetic growth of yeast during the fermentation of EFB
was evaluated.

Result:
Cell concentration increased, ethanol production increased along with the optical density with
the peak reached at 72 h, then declined. Enzymatic hydrolysis process followed by fermentation of
EFB using [Cho][OAc] improved the yield of sugar, saccharification and ethanol around 1.938, 2.879,
and 2.165 times in comparison with untreated EFB with IL. Furthermore, values of specific growth
rates obtained in IL-medium and non-IL-medium are applicable for ethanol production to take place.
The results showed the ability of yeast cells for fermentation even in the presence of IL.

Conclusion:
The results showed that the presence of the IL did not suppress the growth of the yeast
cells and did not impair the fermentation productivity.
Secure Electronic Voting System based on Mobile-app and Blockchain
Authors: Dewan Surbhi , Singh Latika , Gupta Neha 
Published: August 2020

Introduction:
The notion of electronic voting has evolved over a period of time replacing the traditional system
which was based on paper ballots. Several types of electronic voting systems exist, still the implementation is partial and
there is a scope for improvement for making it more secure and user-friendly.Method In this paper, a proof-of-concept is presented which aims to address the issues and challenges in the electoral system, by using the concept of Ethereum blockchain and smart contracts.

Result:
These electronic electoral processes propose a centralized solution that can be easily tampered, thus increasing the
problem of distrust in the citizens. To overcome this blockchain technology can be used for implementing mobile based
electronic voting system. Blockchain technology is aiding in the development of novel digital services that are more secure
and reliable.

Discussion:
The main objective of this paper is to depict how a feasible, secure and reliable mobile voting system can be
built by implementing the concept of blockchain and smart contracts.

Conclusion:
The issue of security and transparency in the voting system can be addressed using blockchain technology.
The present study aims to fulfil these gaps partially by providing use-case for the voting process which is based on mobile
and blockchain technology.
Integration of Conversion Factors for the Development of an Inclusive eHealth Tool With Caregivers of Functionally Dependent Older Persons: Social Justice Design
Authors: Latulippe Karine , Hamel Christine , Giroux Dominique 
Published: August 2020

Background
eHealth can help reduce social health inequalities (SHIs); at the same time, it also has the potential to increase them. Several conversion factors can be integrated into the development of an eHealth tool to make it inclusive: (1) providing physical, technical, and financial access to eHealth; (2) enabling the integration of people at risk of SHIs into the research and development of digital projects targeting such populations (co-design or participatory research); (3) promoting consistency between the digital health literacy level of future users (FUs) and the eHealth tool; (4) developing an eHealth tool that is consistent with the technological skills of FUs; (5) ensuring that the eHealth tool is consistent with the help-seeking process of FUs; (6) respecting the learning capacities of FUs; and (7) being sensitive to FUs’ cultural context. However, only little empirical evidence pointing out how these conversion factors can be integrated into an effective eHealth tool is available.

Objective
On the basis of Amartya Sen’s theoretical framework of social justice, the objective of this study was to explore how these 7 conversion factors can be integrated into an eHealth tool for caregivers of functionally dependent older persons.

Methods
This study was based on a social justice design and participant observation as part of a large-scale research project funded by the Ministère de la Famille through the Quebec Ami des Aînés Program. Data were collected by recording the preparation sessions, the co-design and advisory committee sessions, as well as the debriefing sessions. The results were analyzed using Miles and Huberman’s method.

Results
A total of 78 co-designers participated in 11 co-design sessions, 24 preparation sessions, and 11 debriefing sessions. Of the 7 conversion factors, 5 could be explored in this experiment. The integration of conversion factors has been uneven. The participation of FUs in the development of the tool supports other conversion factors. Respecting the eHealth literacy level of FUs means that their learning abilities and technological skills are also respected because they are closely related to one another and are therefore practically difficult to be distinguished.

Conclusions
Conversion factors can be integrated into the development of eHealth tools that are intended to be inclusive and contribute to curbing SHIs by integrating FU participation into the tool design process.