bluuebunny/crossref_metadata_2025_split huggingface dataset:
Личностные особенности женщин с негативными установками в сфере секса
Authors: Чернецкая Надежда И. , Зырянова Инна А. , Кедярова Елена А. , Монжиевская Вера В. , Уварова Маргарита Ю. 
Published: July 2020

Введение. Проблема изучения личностных особенностей женщин, способствующих их успешной самореализации как субъекта сексуального поведения, сегодня особенно актуальна. В русле тенденции к снижению половой сегрегации женщины должны быть довольны смягчением норм, ограничивающих проявление их сексуальности, однако на практике наблюдается рост числа женщин, обращающихся по поводу сексуальных проблем. Новизна представленного исследования состоит в фокусировании исследовательского интереса непосредственно на выборке женщин с негативными сексуальными установками с целью изучения у них специфических личностных особенностей. Методы. В исследовании приняли участие 152 женщины (клиентки кризисных и консультационных центров г. Иркутска). Отношение женщин к сексу изучалось с помощью «Опросника установок к сексу» Г. Айзенка. Для составления личностных профилей женщин с разными установками в сфере секса использовался опросник Р. Кеттелла (форма С). Достоверность различий оценивалась с помощью критерия Фишера. Результаты. Выделено шесть групп женщин, имеющих позитивное и негативное отношение к различным аспектам сексуальной сферы, у 15,38 % испытуемых выявлено отвращение к сексу. Выявлены достоверные отличия женщин с негативными и позитивными установками к физическому сексуальному контакту по фактору «фемининность – маскулинность». Данный фактор отвечает за выраженность в поведении женщины традиционного женского сексуального поведения, следование жестким моральным нормам, что согласуется с низкими баллами по шкалам теста Айзенка («дозволенность», «обезличенный секс», «сексуальная возбудимость» и «сексуальное либидо»). Обсуждение результатов. Выявлено, что среди женщин с негативными установками в сфере секса преобладают традиционные фемининные взгляды на сексуальность, сохранению брачных уз, а также нетерпимое отношение ко всему постыдному. В личностных профилях женщин с негативными установками в сфере секса преобладают ригидность мышления, высокая нормативность поведения, подчиненность, застенчивость, сдержанность в проявлении эмоций, поглощенность внутренними иллюзиями.
The Metabolism and Pharmacokinetics of Rhein and Aurantio-Obtusin
Authors: Xiao Shun-Li , Guan Liang-Jun , Jiang Ren-Feng , Wang Xiang-Gen , Li Xing , Cai Wei 
Published: July 2020

Background:
Anthraquinones, rhein and aurantio-obtusin were isolated from the herb Duhaldea nervosa
for the first time by our group, which were also found in plants that belong to the plant family Compositae. Anthraquinone
compounds have a range of pharmacological activities such as anti-inflammatory, anti-cancer, antioxidation,
anti-diabetes, etc. and can be used as a laxative, for liver protection, treatment of chronic renal failure, etc.
However, in recent years, anthraquinones have been reported to be cytotoxic to the liver and kidneys. Therefore, it is
very important to study the pharmacokinetics and metabolism of rhein and aurantio-obtusin, which are common
ingredients in many traditional Chinese medicines (TCM). According to our research, the pharmacokinetics and
metabolism of rhein and aurantio-obtusin are comprehensively summarized in the paper for the first time.

Objective:
The study provides comprehensive information on pharmacokinetics and metabolism of rhein and aurantio-
obtusin in different Species; meanwhile, the aim of this review is also to provide a reference for a reasonable
application of TCM enriched with these two ingredients.

Methods:
The metabolism and pharmacokinetics of rhein and aurantio-obtusin were searched by the Web of Science,
PubMed, Google scholar and some Chinese literature databases.

Results:
Rhein and aurantio-obtusin exist mainly in the form of metabolites in the body. Rhein and aurantio-obtusin
and its metabolites might be responsible for pharmacological effects in the body. Therefore, the significance of
studying the in vivo metabolites of rhein and aurantio-obtusin is not only essential to clarify their pharmacological
mechanism, but also to find new active compound ingredients. The metabolism of rhein is different in different species,
so the toxicity effects of rhein may also be different after oral administration in different species; however, the
metabolic profiles of aurantio-obtusin in the liver microsomes of different species are similar.

Conclusion:
This paper not only provides detail regarding the pharmacokinetics of rhein and aurantio-obtusin, but it
is anticipated that it will also facilitate further study on the metabolism of rhein and aurantio-obtusin.
Proteomics Profiling of Plasma Exosomes in VKH Patients
Authors: Zheng Hao , Yang Fuhua , Ea Vicki , Zhou Lei , Wu Lingzi , Zhao Guixia , Shao Xianfeng , Jiang Yuanfeng , Huang Yue , Li Xiaorong , Zhang Xiaomin 
Published: July 2020

Objectives:
Vogt-Koyanagi-Harada syndrome is common autoimmune uveitis
that can cause blindness. Recent studies have shown that plasma exosomes carry
disease-related proteins that may serve as biomarkers. Here, we aimed to find
candidate biomarkers of Vogt-Koyanagi-Harada disease using proteomic analysis of
plasma exosomes.

Methods:
Exosomes were isolated from the plasma of normal controls and Vogt-
Koyanagi-Harada patients in the following groups: a) initial inflammatory attack (active
stage), b) remission after one month of treatment (unstable stage), and c) stationary
phase after three months of treatment (stable stage). Groups were analyzed by mass
spectrometry using isobaric tags for relative and absolute quantitation. After functional
analysis, proteins of interest were verified by ELISA.

Results:
463 proteins were identified in the exosomes. Forty-three were upregulated at
the active inflammation stage, including inflammation-associated proteins. Thirty-one
were downregulated. Gene ontology and pathway analyses revealed differential proteins
related to cell adhesion, cell phagocytosis, cytoskeleton movement, leukocyte migration
across endothelial cells, and platelet activation. By ELISA, Carbonic anhydrase 2 and
Ras-related protein Rap-1b were verified as more plentiful at the active stage compared
to the normal control and stationary phase in exosomes, but not, however, in
microvesicles or plasma.

Conclusion:
Plasma exosomes of Vogt-Koyanagi-Harada patients contain many
proteins related to the degree of inflammation. The levels of Carbonic anhydrase 2 and
Ras-related protein Rap-1b in exosomes can be used as biomarkers for active
inflammation in Vogt-Koyanagi-Harada disease. Further investigation could help study
the pathogenesis of Vogt-Koyanagi-Harada disease and identify therapeutic targets.
Indirect Determination of Amikacin by Gold Nanoparticles as Redox Probe
Authors: Alizadeh Mansureh , Amiri Mandana , Bezaatpour Abolfazl 
Published: July 2020

Background:
Amikacin is an aminoglycoside antibiotic used for many gram-negative bacterial
infections like infections in the urinary tract, infections in brain, lungs and abdomen. Electrochemical
determination of amikacin is a challenge in electroanalysis because it shows no voltammetric peak
at the surface of bare electrodes.

Objective:
In this approach, a very simple and easy method for indirect voltammetric determination of
amikacin presented in real samples. Gold nanoparticles were electrodeposited at the surface of glassy
carbon electrode in constant potential.

Methods:
The effect of several parameters such as time and potential of deposition, pH and scan rates
on signal were studied. The cathodic peak current of Au3+ decreased with increasing amikacin concentration.
Quantitative analysis of amikacin was performed using differential pulse voltammetry by following
cathodic peak current of gold ions.

Results:
Two dynamic linear ranges of 1.0 × 10−8–1.0 × 10-7 M and 5.0 × 10−7–1.0 × 10-3 M were obtained
and limit of detection was estimated 3.0× 10−9 M.

Conclusion:
The method was successfully determined amikacin in pharmaceutical preparation and
human serum. The effect of several interference in determination of amikacin was also studied.
Therapeutic Potential of Ultrasound Neuromodulation in Decreasing Neuropathic Pain: Clinical and Experimental Evidence
Authors: Pérez-Neri Iván , González-Aguilar Alberto , Sandoval Hugo , Pineda Carlos , Ríos Camilo 
Published: July 2020

Background:For more than seven decades, ultrasound has been used as an imaging and diagnostic tool. Today, new technologies, such as focused ultrasound (FUS) neuromodulation, have revealed some innovative, potential applications. However, those applications have been barely studied to deal with neuropathic pain (NP), a cluster of chronic pain syndromes with a restricted response to conventional pharmaceuticals.Objective:To analyze the therapeutic potential of low-intensity (LIFUS) and high-intensity (HIFUS) FUS for managing NP.Methods:We performed a narrative review, including clinical and experimental ultrasound neuromodulation studies published in three main database repositories.Discussion:Evidence shows that FUS may influence several mechanisms relevant for neuropathic pain management such as modulation of ion channels, glutamatergic neurotransmission, cerebral blood flow, inflammation and neurotoxicity, neuronal morphology and survival, nerve regeneration, and remyelination. Some experimental models have shown that LIFUS may reduce allodynia after peripheral nerve damage. At the same time, a few clinical studies support its beneficial effect on reducing pain in nerve compression syndromes. In turn, Thalamic HIFUS ablation can reduce NP from several etiologies with minor side-effects, but some neurological sequelae might be permanent. HIFUS is also useful in lowering non-neuropathic pain in several disorders.Conclusion:Although an emerging set of studies brings new evidence on the therapeutic potential of both LIFUS and HIFUS for managing NP with minor side-effects, we need more controlled clinical trials to conclude about its safety and efficacy.
Health Information Technology and Diabetes Management: A Review of Motivational and Inhibitory Factors
Authors: Dehnavi Zari , Ayatollahi Haleh , Hemmat Morteza , Abbasi Rowshanak 
Published: July 2020

Background:
Health information technology helps patients to take better care of themselves
and improves health status of patients with chronic diseases, such as diabetes.

Objective:
This study aimed to identify factors influencing the use of health information technology in
diabetes management.

Methods:
This was a review study conducted in 2019. To obtain the related articles, databases, including
Scopus, Web of Science, Proquest, and PubMed, were searched and the time frame was between
2010 and 2018. Initially, 1159 articles were retrieved and after screening, 28 articles were selected to be
included in the study.

Results:
Factors influencing the use of health information technology in diabetes management could
be divided into the motivational and inhibitory factors, and each of them could be categorized
into five groups of organizational, technical, economic, individual, and ethical/legal factors. The motivational
factors included training, system ease of use, economic support, having computer literacy,
and maintaining privacy and confidentiality. The inhibitory factors included a lack of long-term
planning, technical problems, inadequate financial resources, old age, and concerns over confidentiality
issues.

Conclusion:
Identifying motivational and inhibitory factors can help to make better use of technology
for diabetes management. This approach, in turn, can improve the acceptability of the technology and
save cost, reduce long-term complications of diabetes, and improve the quality of life in diabetic patients.
Simultaneous Determination of D-amino Acids in Rat Urine by Highperformance Liquid Chromatography-tandem Mass Spectrometry Method: Application to Investigate the Clinical Value of D-amino Acids in the Early Diagnosis of Alzheimer’s Disease
Authors: Zhang Min , Zhang Shuting , Yu Weichao , Li Xiaoyan , Ma Ning , Cui Yan 
Published: July 2020

Background:
D-amino acids are closely related to the development and progression of
Alzheimer's disease (AD) and are expected as the novel biomarkers for AD diagnosis.

Objective:The aim was to investigate the potential clinical value of D-amino acids for Alzheimer's
disease.

Methods:A simple and sensitive HPLC/MS-MS method was developed for the simultaneous determination
of D-alanine, D-glutamine, D-proline and D-serine in rat urine. The samples were firstly pretreated
by methanol, then derivatized by 7-chloro-4-nitrobenzoxadiazole with Fudosteine as internal
standard, enantioseparated on Sumichiral OA-2500S column, using a mobile phase composed of acetonitrile-
methanol (50:50, v/v) containing 0.5% formic acid, and detected with 4000 Qtrap MS/MS in
electrospray-ionization source by negative ion mode.

Results:The established method was successfully applied to determine the D-amino acid levels in rat
urine from 20 Alzheimer's disease rats and 20 age-matched normal controls. The mean levels of Damino
acids in the urine of Alzheimer's disease rats were all significantly lower than those in normal
controls. Based on the contents of D-amino acids, the distinction model between Alzheimer's disease
rats and normal controls was established by the Bayesian discriminant analysis.

Conclusion:
The relationship between Alzheimer's disease and D-amino acids revealed that D-amino
acids would be potential biomarkers for Alzheimer’s disease.
Anlotinib Inhibits Cell Proliferation, Migration and Invasion via Suppression of c-Met Pathway and Activation of ERK1/2 Pathway in H446 Cells
Authors: Tang Xiali , Zheng Ying , Jiao Demin , Chen Jun , Liu Xibang , Xiong Shan , Chen Qingyong 
Published: July 2020

Background:
Small Cell Lung Cancer (SCLC) represents the most aggressive pulmonary neoplasm and is
often diagnosed at late stage with limited survival, despite combined chemotherapies. The purpose of this study was to
investigate the effect of anlotinib on SCLC and the potential molecular mechanisms.

Methods:
Cell viability was assessed by CCK-8 assay to determine the adequate concentration of anlotinib. Then, effects
of anlotinib on cell apoptosis, cell cycle distribution, migration and invasion were analyzed by flow cytometry, PI
staining, wound healing assay and transwell assay, respectively. The protein expression of c-met and ERK1/2 pathways in
H446 cells were assessed by western blot analysis.

Result:
In this study, we found that anlotinib significantly reduced the cell viability of H446 cells, induced G2/M cell
cycle arrest and decreased invasion and migration of H446 cells. Futhermore, we also found that anlotinib could suppress
c-met signal transduction and activate the ERK1/2 pathway in H446 cells. More importantly, c-met was involved in the
effects of anlotinib on migration and invasion in H446 cells.

Conclusion:
Taken together, our results demonstrated that anlotinib was a potential anticancer agent that inhibited cell
proliferation, migration and invasion via suppression of the c-met pathway and activation of the ERK1/2 pathway in H446
cells.
Antioxidant and Antiproliferative Activity of Selected Medicinal Plants of Lower Assam, India: An In Vitro and In Silico Study
Authors: Swargiary Ananta , Verma Akalesh K. , Singh Sweta , Roy Mritunjoy K. , Daimari Manita 
Published: July 2020

Background:
The use of medicinal plants for general wellbeing and disease treatment is a common practice among tribal
communities of Kokrajhar districts of Assam. However, little works have been done to study the pharmacological aspect of the plants.

Objectives:
The present study intends to study the antioxidant and antiproliferative properties of selected medicinal plants used by the
tribal communities of Kokrajhar district of Assam since ancient times.

Methods:
Five traditionally important medicinal plants namely, Cassia fistula, Citrus grandis, Lindernia crustacea, Sacciolepis
myosuroides, and Zingiber zerumbet were investigated for antioxidant, antiproliferative (cytotoxic) and apoptosis-inducing potential in
the malignant cancer cell line. Phytochemical content such as phenolic and flavonoid content were estimated following standard protocol.
The methanolic extract of plants were investigated following phosphomolybdate method (TAC), FRAP, DPPH, ABTS, and TBARS
assays. Antiproliferative activities of the plants were carried out by MTT assay in DL and PBMC cells. The apoptotic study was carried
out following the acridine orange and ethidium bromide staining method and fluorescent microscopic imaging. Based on the significant
(P≤0.05) high apoptotic inducing potential of the plant and to further dissect the molecular mode of action including downstream
biological action, major phytochemicals derived from L. crustacea were investigated for its prospective binding affinity with antiapoptotic cancer target proteins.

Results:
Antioxidant studies by FRAP, DPPH, ABTS, and TBARS assay revealed that all the five plants contain considerable free radical
scavenging activity. C. fistula showed the strongest free radical scavenging activity while the fruit peel extract of C. grandis showed poor
activity. The overall antioxidant activities of plants such as TAC, FRAP, DPPH, ABTS, and TBARS may be arranged in decreasing
activity as C. fistula > Z. zerumbet > L. crustacea > S. myosuroides > C. grandis. MTT based cell proliferation study showed that all the
plants extract significantly (P≤0.05) inhibited cell viability with negligible cytotoxicity (~5-12%) in normal cells. Moreover, L. crustacea
showed promising antiproliferative and apoptosis-inducing ability against Dalton’s lymphoma. It is worth mentioning that the major
bioactive compounds of the most potent plant extract, L. crustacea interacted with anti-apoptotic proteins (cancer target) with
higher affinity and the results are compared with reference inhibitors.

Conclusion:
It is worth noting that these plants have the potential to consider for further scientific studies in different cell lines and
animal models. Furthermore, isolation and characterization of bioactive compound(s), may promise the discovery of new and valuable
drugs candidate to tackle various human diseases.
Recent Development of Copolymeric Nano-Drug Delivery System for Paclitaxel
Authors: Chen Shiyu , Song Zhimei , Feng Runliang 
Published: July 2020

Background:
Paclitaxel (PTX) has been clinically used for several years due to its good therapeutic
effect against cancers. Its poor water-solubility, non-selectivity, high cytotoxicity to normal tissue and worse
pharmacokinetic property limit its clinical application.

Objective:
To review the recent progress on the PTX delivery systems.

Methods:
In recent years, the copolymeric nano-drug delivery systems for PTX are broadly studied. It mainly
includes micelles, nanoparticles, liposomes, complexes, prodrugs and hydrogels, etc. They were developed or
further modified with target molecules to investigate the release behavior, targeting to tissues, pharmacokinetic
property, anticancer activities and bio-safety of PTX. In the review, we will describe and discuss the recent
progress on the nano-drug delivery system for PTX since 2011.

Results:
The water-solubility, selective delivery to cancers, tissue toxicity, controlled release and pharmacokinetic
property of PTX are improved by its encapsulation into the nano-drug delivery systems. In addition, its
activities against cancer are also comparable or high when compared with the commercial formulation.

Conclusion:
Encapsulating PTX into nano-drug carriers should be helpful to reduce its toxicity to human, keeping
or enhancing its activity and improving its pharmacokinetic property.
Yoga can Alter the Autonomic Neural Activity: A Critical Analysis
Authors: De Anup , Mondal Samiran 
Published: July 2020

Background:
Modern lifestyle leads a greater psychotechnological stress and it results increase of autonomic
imbalances. This predicts disturbance of the normal mental state and cognition. The current researchers found clear relationship between yoga practice and parasympathetic dominance.

Objectives:
The purpose of the review study was to analyze the scientific literatures related to yoga and autonomic neural
responses.

Methods:
Researchers collected scientific evidences through electronic online databases; PubMed, Embase, Medline,
Google scholar, Web of science, PsycINFO, Shodhganga; Europe PMC; Scopus and critically analyzed all the entire relevant articles according to the purpose of this study. After the exhaustive search and selecting the studies on the basis of
inclusion criteria, 11 full text articles of galvanic skin resistance and 75 articles related to autonomic function were
shortlisted for qualitative analysis.

Results:
Yogic practices including meditation, pranayama, asana and integrated yoga increase the high frequency band
and decrease the low frequency band of the heart rate variability spectrum and it reduces the stress via limbic activity and
increases the better psychophysiological relaxation.

Conclusions:
Yogic practice may enhance the vagal activity which influences autonomic flexibility.
Cloud Computing Demand Elasticity Algorithm based on Ant Colony Algorithm
Authors: Liu Chunyu , Mu Fengrui , Zhang Weilong 
Published: July 2020

Background:
In the recent era of technology, the traditional Ant Colony Algorithm
(ACO) is insufficient in solving the problem of network congestion and load balance, and network
utilization.

Methods:
This paper proposes an improved ant colony algorithm, which considers the price factor
based on the theory of elasticity of demand. The price factor is denominated in the impact on the
network load which means indirect control of network load, congestion or auxiliary solution to calculate
the idle resources caused by the low network utilization and reduced profits.

Results:
Experimental results show that the improved algorithm can balance the overall network
load, extend the life of path by nearly 3 hours, greatly reduce the risk of network paralysis, and increase
the profit of the manufacturer by 300 million Yuan.

Conclusion:
Furthermore, the results show that the improved method has great application value in
improving network efficiency, balancing network load, prolonging network life and increasing
network operating profit.
Design and Research of Intelligent Logistics Robot based on STM32
Authors: Mu Fengrui , Liu Chunyu 
Published: July 2020

Background:
At present, China's logistics industry is trying to change from laborintensive
to technology-intensive, from the traditional model to modernization, intelligent upgrade,
accompanied by the application and popularization of various advanced technologies and equipment.
Nowadays, intelligent robots with functions such as handling, stacking, and sorting have become
a hot topic in the logistics industry. To solve the problem of labor costs increase the logistics
demand of logistics, improve the efficiency of processing of materials, the authors have designed
main STM32F427 microcontroller chip, with smooth, round of omnidirectional mobile platform of
vehicle chassis, external collision distance sensor, gyroscope and infrared sensors, temporary storage,
and transportation of goods such as multi-functional integrated logistics robot.

Methods:
According to the actual application requirements, the mechanical structure of the logistics
robot, the hardware, and the software of the control system is designed.

Results:
The experimental results show that the transportation and storage of materials in specific
sites are well realized. The grasping and releasing accuracy and the positioning accuracy of the robot
are relatively reliable. The study of the behavior of average tracking accuracy and average obstacle
avoiding capability is the major contribution in this paper.

Conclusion:
The experimental results fully prove that the robot designed in this paper has many
functions, high intelligence, and strong practicability.