bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involving cross-border organized crime networks from ex-Soviet sources in support of terrorism and their influence on regional economic development
Authors: Trăistaru Marius 
Published: August 2020

Abstract
This paper indicates how the actions of organized crime networks (especially the former the former Soviet Union) can affect, from an economic point of view, the elaboration of policies to combat transnational terrorism. Transnational organized crime poses a significant and growing threat to national and international security, with dire implications for public safety, public health, democratic institutions, and economic stability across the globe. Not only are criminal networks expanding, but they also are diversifying their activities, resulting in the convergence of threats that were once distinct and today have explosive and destabilizing effects. Ex-soviet organized crime networks represent a significant threat to economic growth and democratic institutions. Nuclear material trafficking is an especially prominent concern in the former Soviet Union. Because some terrorist-extremist organizations are criminal groups that have a specific organization, logistics, specific training and education systems that cannot work without having material and financial resources. As a result, one of the most effective ways to fight the threat of terrorist organizations is to combat terrorism financing. Within the European Union, the primary responsibility for combating terrorist financing lies with the Member States. However, the EU can and should play a supporting role in helping to respond to the transnational nature of the threat.
Challenges and opportunities for creative-innovative clusters partnerships
Authors: Neamţu Daniela Mihaela , Bejinaru Ruxandra , Hapenciuc Cristian Valentin 
Published: August 2020

Abstract
Clusters of innovation are global economic “hot spots” where new technologies germinate at an astounding rate and where pools of capital, expertise, and talent foster the development of new industries and new ways of doing business. They are vibrant, effervescent ecosystems composed of startups, businesses that support the startup process, and mature enterprises (many of whom evolved rapidly from a startup history). In these ecosystems, resources of people, capital, and know-how are fluidly mobile and the pace of transactions is driven by a relentless pursuit of opportunity, staged financing, and short business model cycles. The aim of this paper, clustering, which is an important model in the development of the countries and the concept of innovation have been reviewed together. The most prominent feature of the industry is to produce Technology. Countries to focus on knowledge-intensive industries and businesses as a result of regional cluster policies for innovation are seen that there is a relation between. Clustering is an important model for an innovational development in Romania. The analysis was carried out for a period of 3 years, for which there were registered the main achievements in the field of product innovation, processes, organizational forms and marketing methods, new or significantly improved, obtained by companies, starting from January 2016 until December 2018, representing Romania’s contribution to the evaluation of the results of the European statistical research on innovation, 2018. Following the innovative activities in which the companies are engaged does the characterization of the innovation. The National Institute of Statistics provides the necessary means for carrying out statistical research on innovation in businesses in the business and industrial environment.
Sequential priming in the detection of the facial expression: New approach in the study of emotional detection
Authors: León Fernando Gordillo , Nieto Miguel Ángel Pérez , Hernández Lilia Mestas , Arana Martínez José M. , Parra Gabriela Castillo , Pérez Rafael Manuel López 
Published: August 2020

Abstract
The effective detection of those facial expressions that alert us to a possible threat is adaptive. Hence the reason that studies on face sampling have involved analysing how this process occurs, with evidence to show that the eyes focus mainly on the upper side of the face; nevertheless, no clear determination has been made of the relationship between the efficacy in detection (speed and accuracy) and the way in which emotions are visually tracked on the face. A sequential priming task was therefore held in which the four quadrants of the face were displayed consecutively, for 50 ms each one, and in a different order (24 sequences). The results reveal a quicker response when the priming sequence begins in the upper part, continues downward to the right-hand side of the face, and then follows an anti-clockwise direction. The results are discussed in the light of studies using the Eye-Tracking technique.
High frequency of BRCA recurrent mutations in a consecutive series of unselected ovarian cancer patients
Authors: Chicos Andrei , Negura Lucian , Braescu Rares , Morariu Aliona , Negura Anca , Chicos Andreea , Lupascu Cristian 
Published: August 2020

Abstract
Hereditary predisposition to breast and ovarian cancer (HBOC) is diagnosed by molecular analysis of deleterious mutations in BRCA genes, allowing oncogenetic follow-up of patients and of their families. BRCA testing addresses only to HBOC families, using restrictive inclusion criteria based on familial history of cancer and age at diagnosis. Sporadic ovarian cancer has high incidence and mortality in Romania, with low median age of diagnosis and possibly a higher magnitude of hereditary contribution comparing to othe populations. However, sporadic ovarian cancers do not qualify for BRCA testing according to inclusion criteria, and a complete BRCA screening of all cancers is neither feasible nor recommended. Despite the large diversity of BRCA mutations worldwide, some recurrent mutations have higher frequencies in diverse populations. Precisely screening for recurrent mutations in a target population allows to rapidly identifying mutation carriers without sequencing the entire BRCA genes. In Romanian population and neighboring countries, several recurrent mutations have already been described. In a consecutive series of 50 sporadic ovarian cancer patients, not qualifying for BRCA complete testing, we screened for 9 most common BRCA mutations, by multiplex-PCR, RFLP and targeted Sanger sequencing. Our results revealed 6 different BRCA mutations in 8 unrelated patients, with a frequency of 16%, much higher than expected. We further recommend screening for the identified mutations in larger series of cancer patients. The results are highly beneficial to cancer patients, healthy relatives, and overall, considering prevention in cancer a priority, to public health system and future of oncogenetics in Romania
Mucopolysaccharidosis type I - Clinical and genetic characteristics of Romanian patients
Authors: Alkhzouz Camelia , Lazea Cecilia , Miclea Diana , Asavoaie Carmen , Nascu Ioana , Pop Tudor , Grigorescu-Sido Paula 
Published: August 2020

Abstract

Background: Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder caused by a deficiency of α-L-iduronidase (IDUA), which leads to the accumulation of partially digested glycosaminoglycans (dermatan sulfate and heparan sulfate) in the lysosomes and induces multisystemic alteration. Hurler (severe), Scheie (mild), and Hurler/Scheie (intermediate) syndromes are clinical subtypes of MPS-I. To date, more than 290 IDUA mutations have been reported. The purpose of this study was to present the clinical and genetic characteristics of Romanian MPS I syndrome patients and their genotype-phenotype correlation.

Patients and methods: Seven patients (5 girls and 2 boys) with MPS type I, belonging to 4 unrelated families, aged 0,75-17.9 years, were enrolled. The study methods consisted in: clinical and standard auxological assessment, bone radiographs, joint ultrasonography, goniometry, neurological and psychological evaluation, hepatic and splenic ultrasonography, cardiological evaluation, otorhinolaryngology examination, ophthalmological examination, spirometry, α-L-iduronidase enzyme activity assay and molecular analysis.

Results: The seven patients originated from 4 unrelated families, three patients with severe, two patients with intermediate and two with attenuated clinical phenotype. Each patient presented the classical picture of MPS type I picture, represented by: variable coarse facial features, arthropathy, hepatosplenomegaly, cardiac involvement, respiratory dysfunction and neurological impairment. Five patological variants, three point mutations (p.Q70 *, p.I238Q and p.K324R), two deletion c.1045_1047delGAC, c.46_57delTCGCTCCTG) and an insertion (c.1389 insC) were identified in both alleles of the ADUA gene in homozygous or heterozygous form. Two novel mutations (p.K324R and c.1389 insC) were reported. The p.Q70*(c.208C>T) variant was identified in 2 families with severe form of disease (Hurler syndrome) in homozygous status in one family and in compound heterozygous status in the other family.

Conclusion: The p.Q70* missense variant was the most frequent, correlated in all the cases who presented it with severe form, Hurler syndrome, the other mutations being usually isolated and particular for each patient, associated in our patients with less severe MPS I phenotype, as Hurler-Scheie or Scheie syndrome. The results of this study indicated the mutational heterogeneity of the IDUA gene and the difficulty to indicate some correlation between the genotype and phenotype in MPS I patients.
“Man as Literature. Recurring Memories”
Authors: Necula Constantin 
Published: August 2020

Abstract
In the reading cultural openness, the human effort is the key to a de-construction that opens the source of knowledge. Can we only build libraries? Do we only read the book or also the author? The line of the book’s culture runs parallel to daily life or breaks the rhythm or tense knowledge. How do we build man-literature? Is knowledge an Oath in Gandhi’s meaning, a Covenant with a memory? And how does the dimension of human dignity evolve from reading into knowledge? We have no answer. However, we have a description of the interrogation process.
Current trends in paediatric infections in the Russian Federation
Authors: Lobzin Yu. V. , Rychkova S. V. , Uskov A. N. , Skripchenko N. V. , Fedorov V. V. 
Published: August 2020

The onset of 2020 clearly demonstrated that infection agents pose a major threat to mankind. Current infectiology is shaped by resurrection of “old” seemingly forgotten infections, emergence of “new” infection agents, unusual combinations of known agents, evolving resistance of microorganisms to antibacterial drugs, transformation of human microbiome leading to distortions in herd immunity and, ultimately, emergence of healthcare-related infectious diseases, not letting alone threats of bioterror. Infection agents evolve together with mankind. Novel facets emerge in infectiology, alongside with trends in diagnosis, treatment and prevention of infectious diseases that become more diverse as the list of pathogens grows. Human and infection agent links extend beyond antagonistic relations towards symbiosis. Microorganisms adapt quickly in the new technogenic environment giving rise to novel pathogens and making it unlikely for the mankind to get free from infections any time soon.The total economic damage from infectious diseases increases by year, despite continuous improvement in therapy. Infectious mortality in children aged 0 to 14 years is the top fourth among other causes of death. The work assesses comparative dynamics of “common” childhood infections in the Russian Federation during 2018–2020. We analyse ofﬁcial statistics on paediatric infectious morbidity, comparative dynamics of main infectious diseases (acute respiratory diseases, intestinal infections of bacterial and viral nature, neuroinfections, anthropozoonotic infections, viral hepatitises), assess trends in morbidity of vaccine-preventable infections in children and adults in the Russian Federation, with greater detail towards selected regions, from January 2018 to April 2020.
Occurrence of internal root resorption defects in anterior teeth with a history of concussion injury: A cross-sectional study among select adult North Indian dental patients
Authors: Bains Rhythm , Tikku Aseem P. , Verma Promila 
Published: August 2020

Objectives:
The aim of this study was to assess the frequency of internal resorption (IR) defects in select adult North Indian population with a history of concussion injury to their anterior teeth.

Material and Methods:
The study population consisted of patients reporting with a history of concussion injury to their anterior teeth. At least two intraoral periapical radiographs, one at central and other at a 20° horizontal angulation, were taken for each of the affected teeth to check for any IR defect. The radiographs were inspected after placing them over a viewing box using magnifying glasses. Percentage of IR defects and their occurrence on the basis of tooth type, duration of trauma, gender, and side was assessed.

Results:
A total of 1507 patients reported with a history of a traumatic dental injury (TDI) to their anterior teeth. About 37.1% (560/1507) patients and 602 teeth with TDI had a history concussion injury. The percentage of patients with concussion injuries resulting in IR defect was 3.3% (19/560), and the percentage of teeth with IR defect was 3.16% (19/602). About 68.42% (13/19) were in males, and 31.58% (6/19) were in females; however, the difference was not statistically significant (χ2 = 1.05, P = 0.590). Most of the patients reported with a history of TDI within 0–5 years back, and the median age at the time of presentation was 20 years. Maxillary left central incisor was most affected, 4.84% (9/186) followed by maxillary right central incisor 3.5% (7/200) mandibular left lateral incisor 3.85% (1/26), mandibular left central incisor 3.57% (1/28), and maxillary lateral incisor 1.52% (1/66). Out of the 19 IR defects, 15 (78.9%) were located in the root, four were located coronally (21.05%), out of which 2 had a pink-colored crown.

Conclusion:
Silent injuries such as concussion and subsequent IR can potentially weaken the tooth; therefore, follow-up of patients with a history of TDIs is vital to rule out any developing but obscure resorptive defects.
Automated In Silico Identification of Drug Candidates for Coronavirus Through a Novel Programmatic Tool and Extensive Computational (MD, DFT) Studies of Select Drug Candidates
Authors: Geoffrey A S Ben , Madaj Rafal , Sanker Akhil , Tresanco Mario Sergio Valdés , Davidd Host Antony , Roy Gitanjali , Saji Rinnu Sarah , Yakubu Abdulbasit Haliru , Malgija Beutline 
Published: August 2020

The work is composed of python based programmatic tool that automates the dry lab drug discovery workflow for coronavirus. Firstly, the python program is written to automate the process of data mining PubChem database to collect data required to perform a machine learning based AutoQSAR algorithm through which drug leads for coronavirus are generated. The data acquisition from PubChem was carried out through python web scrapping techniques. The workflow of the machine learning based AutoQSAR involves feature learning and descriptor selection, QSAR modelling, validation and prediction. The drug leads generated by the program are required to satisfy the Lipinski’s drug likeness criteria as compounds that satisfy Lipinski’s criteria are likely to be an orally active drug in humans. Drug leads generated by the program are fed as programmatic inputs to an In Silico modelling package to computer model the interaction of the compounds generated as drug leads and the coronaviral drug target identified with their PDB ID : 6Y84. The results are stored in the working folder of the user. The program also generates protein-ligand interaction profiling and stores the visualized images in the working folder of the user. Select drug leads were further studied extensively using Molecular Dynamics Simulations and best binders and their reactive profiles were analysed using Molecular Dynamics and Density Functional Theory calculations. Thus our programmatic tool ushers in a new age of automatic ease in drug identification for coronavirus. The program is hosted, maintained and supported at the GitHub repository link given belowhttps://github.com/bengeof/Programmatic-tool-to-automate-the-drug-discovery-workflow-for-coronavirus
Kebijakan Perlindungan Korban Perkosaan dalam Hukum Positif
Authors: Widiastuti Tri Wahyu 
Published: August 2020

AbstractProtection to the victim of rape is very important for victim, family, offender and crime prevention. Restitution from the offender will increase responsibility and disappear guilty feel, so will be easier for character building in the jail. Protection policy to the rape victim in Indonesia criminal law arrange in article 98-101 KUHAP, which giving to the victim for accuse permission merger of compensation to the process of criminal justice.Keywords: Law protection, rape victim, positive lawÂ AbstrakPerlindungan terhadap korban perkosaan sangat penting bagi korban, keluarga, pelaku dan untuk pencegahan kejahatan. Restitusi bagi pelaku akan meningkatkan pertanggungan jawab dan menghilangkan rasa bersalah, sehingga akan memudahkan untuk memperbaiki kepribadiannya di dalam penjara. Kebijakan perlindungan korban perkosaan dalam hukum pidana Indonesia diatur dalam Pasal 98-101 Kitab Undang-Undang Hukum Acara Pidana (KUHAP), yang memberikan kepada korban untuk menggabungkan gugatan ganti rugi dalam proses peradilan pidana.Kata kunci : Perlindungan hukum, korban perkosan, hukum positif
Implikasi Peraturan Mahkamah Agung No. 2 Tahun 2012 Terhadap Penegakan Hukum Pidana di Indonesia
Authors: Kusumo Bambang Ali 
Published: August 2020

AbstractPerma No. 02/2012 Â on the level of investigation and prosecution does not have any implications or impact on the enforcement of penal. This is due to socialization Perma No. 02/20012 has not been done optimally. In addition, this rule does not bind to be implemented by the investigator or prosecutor. Then Perma at the level of examinition in court does not have any impact or implications for the enforcement penal. This is due to the Chairman of the District Court did not respond to calls that actually explicitly requiredÂ to be implemented. Not responding is due, first: the suggestion that such Perma not a law, so it is not binding. The second: the Chairman of the District Court did not have the authority to change misdrijven become lichte misdrijven that is authority for the prosecutor.Â Â Â Â Â Â Â Â Keywords: law enforcement, legality, justice.Â Â AbstrakPeraturan Mahkamah Agung (Perma) Â No. 02 Tahun 2012 tentang Penyesuaian Batasan Tindak Pidana Ringan dan Jumlah Denda dalam KUHP pada tingkat penyidikan dan penuntutan belum mempunyai implikasi atau dampak terhadap penegakan hukum pidana. Hal ini disebabkan sosialisasi Perma No. 02 Tahun 2012 belum dilakukan secara maksimal. Selain itu aturan ini tidak mengikat untuk dilaksanakan oleh penyidik maupun penuntut umum. Kemudian Perma pada tingkat pemeriksaan di pengadilan tidakÂ mempunyai dampak atau implikasi terhadap penegakan hukum pidana. Hal ini disebabkan Ketua Pengadilan Negeri tidak merespon himbauan yang sebenarnya secara eksplisit wajib untuk dilaksanakan. Tidak meresponnya ini disebabkan, pertama: anjuran itu berupa perma bukan suatu undang-undang, sehingga tidak mengikat. Kedua: Ketua Pengadilan Negeri tidak mempunyai kewenangan untuk merubah tindak pidana biasa (misdrijven) menjadi tindak pidana ringan (lichte misdrijven) yang merupakan kewenangan pihak kejaksaan.Kata Kunci: Penegakan Hukum, Kepastian Hukum, Keadilan.
Menciptakan Komunikasi Konstruktif Antar Lembaga Penegak Hukum, Presiden dan KPK Dalam Rangka Pemberantasan Korupsi yang Efektif dan Efisien
Authors: Widodo Wahyu 
Published: August 2020

AbstractThe existence of disharmony between law enforcement agencies, and the Commission president lately konstructive communication requires effort to achieve synergy in order to achieve the eradication of corruption in Indonesia. The approach used in this study is normative. Efforts should be made to create constructive communication between law enforcement agencies, the president of the Commission and institutions in order to eradicate corruption is an effective and efficient trusting, synergistic interaction between law enforcement agencies, and the president of the Commission, in favor of the truth. Obstacles that hinder the creation of constructive communication between law enforcement agencies, the president of the Commission and institutions in order to eradicate corruption are effective and efficient political constraints, legal and socio-economicKeywords: Constructive Communication, Corruption, Effective and EfficientÂ AbstrakAdanya disharmonisasi antara lembaga penegak hukum, presiden dan KPK akhir-akhir ini memerlukan upaya komunikasi konstruktif untuk mewujudkan sinergitas sehingga tercapai pemberantasan korupsi di Indonesia. Pendekatan yang digunakan dalam penelitian ini adalah yuridis normatif. Upaya yang dapat dilakukan untuk menciptakan komunikasi konstruktif antar lembaga penegak hukum,Â presiden dan lembaga KPK dalam rangka pemberantasan korupsi yang efektif dan efisien adalah saling percaya, interaksi yang sinergi antara lembaga penegak hukum, presiden dan KPK, berpihak pada kebenaran. Kendala yang menghambat terciptanya komunikasi konstruktif antar lembaga penegak hukum,Â presiden dan lembaga KPK dalam rangka pemberantasan korupsi yang efektif dan efisien adalah kendala politik, hukum dan sosial ekonomi.Kata Kunci : Komunikasi Konstruktif, Pemberantasan Korupsi, Effektif dan Efisien
Konsistensi Implementasi Hak Menguasai Negara Dalam Upaya Mengatasi Dominasi Perekonomian Asing Guna Mewujudkan Kemandirian Ekonomi Nasional
Authors: Suparji Suparji 
Published: August 2020

Â AbstractThe presidentâ€”Jokowi, has a mandate from the people to make Indonesia to be more equitable and prosperous. In order to fulfill this mandate, he has set nine priority programs known as the concept of Nawa Cipta. This program calls for concrete steps so as not merely a wish list. The most fundamental thing in economics field is how the constitutional mandate that the right to dominate the state can be realized in the management of economic activities, including in dealing with foreign economic domination in IndonesiaKeywords: implementation, the right to dominate the state, foreign economic domination. Â AbstrakPresiden Jokowi telah mendapatkan mandat dari rakyat untuk mewujudkan Indonesia yang lebih adil dan sejahtera. Dalam rangka memenuhi mandat tersebut, telah ditetapkan sembilan program prioritas Â Â Â Â Â yang dikenal dengan konsep Nawa Cipta. Program ini tentunya memerlukan langkah-langkah kongkret sehingga tidak sekedar menjadi daftar keinginan. Hal yang paling mendasar dalam bidang ekonomi adalah bagaimana amanat konstitusi yakni hak menguasai negara dapat diwujudkan dalam pengelolaan kegiatan perekonomian, termasuk dalam mengatasi dominasi perekonomian asing di Indonesia.Â Â Kata kunci: implementasi, hak menguasai negara, dominasi perekonomian asing Â