bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Benefits of Dates Ruthab on Blood Volume On Labor Stage 4th
Authors: Purnama Agus , Melawati Mua 
Published: December 2019

Background: Birth is a natural process and is a physiological condition in a woman. there are 4 stage/times in labor which are 1st time, 2nd time, 3rd time and 4th time. The effort used to facilitate labor is to make contractions and relaxation effective. dates contain tannins which can shorten bleeding time and high glucose as a good source of energy during labor. Purpose: The purpose of this study is to see at the amount of bleeding in the group not given dates and given date ruthab. Method: this study using a quasi-experimental method in two different groups with 34 people treated with primigravida with 17 control groups and 17 intervention groups. given treatment for 4 weeks before the estimated delivery and check the blood volume with a measuring cup.Result: The results showed a significance value of the results of the t-test, namely: 0,000 for the 4th stage, the value was smaller than the significance level (α) of 0.05, meaning Ho was rejected, so it could be decided the hypothesis of the effect of giving wet dates to decreasing blood volume in stage 4th labor can be accepted.Conclusion: dates ruthab can be used as supporting therapy in the labor process and has very convincing benefits
Effectiveness of Toileting Training Mediated With Animated Videos Against To Independence Level of Toileting on Pre-School Children
Authors: Ernawati Nunung , Permata Kartika 
Published: December 2019

Background:The one of development tasks for preschooler that must be passed is toileting activity. Toileting learning need should start at toodler phase, but many children still enuresis experience in the classroom, all students could not do proper toileting, including not knowing how to go to the toilet, not being able to open the pants and not being able to flush the elimination urine and defecatie in Kindergarden-class A of Malang City. Inability to control of elimination urine that cause of pre schooler are less independece for toileting activity.Purpose: to find out the effect of toilet training mediated with animated videos againts to independence level of toileting on pre schooler children in kindergarten-class A of Malang City.Methods: This type of research was analytic observation with a pre-experimental approach. The total population was 38 children, the number of samples 38 children was taken using the total sampling technique. The variable measured is the level of independence of toileting. The data was processed then analyzed using the Wilcoxon test with α <0.05.Results: Based on the results of the study, the level of independence before toileting learning was done 21% independently and 79% not independently. The level of independence after toileting learning is 100% done independently.Wilcoxon test was analyzed, the level of independence was obtained with a p-value of 0,000 which means that p-value <α so that H0 is rejected, which means there is an influence of the learning activity of animated videos on the level of independence of toileting.Conclusion:Based on the results of the study, to improve children's independence, in terms of toileting, can be done early and in the future learning, animated video media can be used as an alternative as a learning media for pre-schooler.
Analysis of Heavy Metal Content in Fried Foods Wrapped in Black Plastic as a Fried Food Wrap
Authors: Rahman Fathor , Sari Nia , Indasah Indasah 
Published: December 2019

Fried foods or weci are also called Ote-ote. Ote-ote is a type of fried food which is usually more wrapped in black plastic, where the plastic contains the presence of heavy metal Pb. So this study aims to analyze the effect of heavy metal content (Pb) using new cooking oil and used cooking oil on fried food processing with a hot temperature of 80 0C, moderate temperature of 45 0C, and cold temperature of 25 0C with a 10 minute wrapping time. This study uses a Randomized Block Design (RBD) method, the sampling technique is carried out by Random Sampling with a sample of 30 consisting of fried foods and oil. Data analysis techniques used the Two Factorial Anova test and Duncan's Test. Independent variables examined include cooking oil and wrapping methods with a hot temperature of 80 ° C, medium temperature of 45 ° C, and cold temperatures of 25 ° C with a packing time of 10 minutes. The results of the research in the Laboratory showed that the heavy metal content of Pb in fried foods wrapped in the highest black plastic with a hot temperature of 80 0C was an average of 0.881 ppm, while the lowest in the average control was 0.294 ppm in the treatment of used oil. In the new oil treatment, the highest metal content of Pb weight was 0.428 ppm, while the lowest in the control was 0.173 ppm. From the results of the Two Factorial Anova test that the interaction between oil and wrapping temperature there is an influence on Pb levels in fried foods with a significant value of <0.05, this means that there are interactions in all types of fried food treatment.
Fried foods that experience Pb contamination cause food to not meet the requirements, this is because the wrapping process uses black plastic with different temperature treatments, where the more hot fried food is packaged, the more Pb content in fried foods, when food enters the body through blood flow will inhibit the cell's metabolic system, one of which is inhibiting Hb synthesis in the bone marrow which results in poor cognitive development, a weakened immune system accompanied by symptoms of autism and even death
Analysis of Emotional Intelligence, Environment and Discipline on Student Learning Achievement
Authors: Yunita Yunita , Indasah Indasah , Farida Siti 
Published: December 2019

Education is very important for improving the quality of human resources. Associated with the world of education, to create high quality and high achievers. Factors that can influence learning include emotional intelligence, the environment and the discipline in which individuals carry out certain activities so that they can achieve maximum performance. The purpose of the study was to analyze the effect of emotional intelligence , environment and discipline on student achievement in Health Vocational School Visi Global in Banyuwangi Regency . In this study, the research design used was cross sectional . The study population was all students of Banyuwangi Health Vocational School Visi Global 117 students and a sample of 91 people using stratified random sampling . Collecting data using a questionnaire sheet and then analyzed using multiple linear regression test. The results showed that a significant probability of F value of 0.000 <0.05 means that there is an influence of emotional intelligence (X1), learning environment (X2) and learning discipline (X3) simultaneously or partially have a significant effect on learning achievement (Y) in Vocational School in Visi Global Banyuwangi Regency. Based on the results of this study, it needs to be at the level of things that affect learning achievement by providing facilities and infrastructure that support learning that is not yet available and create a more comfortable learning environment.
The Effect Of Coconut Water Consumption On Labor Advancement In The Phase I Activities In The Mother
Authors: Wardhani Ratih Kusuma , Ernawati Endah , Dinastiti Vide Bahtera 
Published: December 2019

Prolonged labor can increase abnormalities in the physiology of labor and increase the number of labor with cesarean section. Efforts in overcoming the progress of labor are hampered by caring for the mother in the labor process, including giving freedom to the mother to eat or drink as long as the mother wants to need fulfill her nutrition. This research was Analyze the effect coconut water consumption to advancement labor of active process phase I to intranatal. Design was used quasy experimental with One group pre and post test technique. Data was analyzed with Mann-Whitney. Result showed that there was p-value 0,043 < α (0,05) so There was a significant influence of the provision of coconut water on the progress of labor in the first stage. There are correlation coconut water on average accelerates the opening by 54 minutes.
Fluorescence-guided stereotactic biopsy: a proof-of-concept study
Authors: Lynagh Robert , Ishak Mark , Georges Joseph , Lopez Danielle , Osman Hany , Kakareka Michael , Boyer Brandon , Goldman H. Warren , Eschbacher Jennifer , Preul Mark C. , Nakaji Peter , Turtz Alan , Yocom Steven , Appelt Denah 
Published: December 2019

OBJECTIVEAccurate histopathological diagnoses are often necessary for treating neuro-oncology patients. However, stereotactic biopsy (STB), a common method for obtaining suspicious tissue from deep or eloquent brain regions, fails to yield diagnostic tissue in some cases. Failure to obtain diagnostic tissue can delay initiation of treatment and may result in further invasive procedures for patients. In this study, the authors sought to determine if the coupling of in vivo optical imaging with an STB system is an effective method for identification of diagnostic tissue at the time of biopsy.METHODSA minimally invasive fiber optic imaging system was developed by coupling a 0.65-mm-diameter coherent fiber optic fluorescence microendoscope to an STB system. Human U251 glioma cells were transduced for stable expression of blue fluorescent protein (BFP) to produce U251-BFP cells that were utilized for in vitro and in vivo experiments. In vitro, blue fluorescence was confirmed, and tumor cell delineation by fluorescein sodium (FNa) was quantified with fluorescence microscopy. In vivo, transgenic athymic rats implanted with U251-BFP cells (n = 4) were utilized for experiments. Five weeks postimplantation, the rats received 5–10 mg/kg intravenous FNa and underwent craniotomies overlying the tumor implantation site and contralateral normal brain. A clinical STB needle containing our 0.65-mm imaging fiber was passed through each craniotomy and images were collected. Fluorescence images from regions of interest ipsilateral and contralateral to tumor implantation were obtained and quantified.RESULTSLive-cell fluorescence imaging confirmed blue fluorescence from transduced tumor cells and revealed a strong correlation between tumor cells quantified by blue fluorescence and FNa contrast (R2 = 0.91, p < 0.001). Normalized to background, in vivo FNa-mediated fluorescence intensity was significantly greater from tumor regions, verified by blue fluorescence, compared to contralateral brain in all animals (301.7 ± 34.18 relative fluorescence units, p < 0.001). Fluorescence intensity measured from the tumor margin was not significantly greater than that from normal brain (p = 0.89). Biopsies obtained from regions of strong fluorescein contrast were histologically consistent with tumor.CONCLUSIONSThe authors found that in vivo fluorescence imaging with an STB needle containing a submillimeter-diameter fiber optic fluorescence microendoscope provided direct visualization of neoplastic tissue in an animal brain tumor model prior to biopsy. These results were confirmed in vivo with positive control cells and by post hoc histological assessment. In vivo fluorescence guidance may improve the diagnostic yield of stereotactic biopsies.
Early postmarket results with PulseRider for treatment of wide-necked intracranial aneurysms: a multicenter experience
Authors: Srinivasan Visish M. , Srivatsan Aditya , Spiotta Alejandro M. , Hendricks Benjamin K. , Ducruet Andrew F. , Albuquerque Felipe C. , Puri Ajit , Amans Matthew R. , Hetts Steven W. , Cooke Daniel L. , Ogilvy Christopher S. , Thomas Ajith J. , Enriquez-Marulanda Alejandro , Rai Ansaar , Boo SoHyun , Carlson Andrew P. , Crowley R. Webster , Rangel-Castilla Leonardo , Lanzino Giuseppe , Chen Peng Roc , Diaz Orlando , Bohnstedt Bradley N. , O’Connor Kyle P. , Burkhardt Jan-Karl , Johnson Jeremiah N. , Chen Stephen R. , Kan Peter 
Published: December 2019

OBJECTIVETraditionally, stent-assisted coiling and balloon remodeling have been the primary endovascular treatments for wide-necked intracranial aneurysms with complex morphologies. PulseRider is an aneurysm neck reconstruction device that provides parent vessel protection for aneurysm coiling. The objective of this study was to report early postmarket results with the PulseRider device.METHODSThis study was a prospective registry of patients treated with PulseRider at 13 American neurointerventional centers following FDA approval of this device. Data collected included clinical presentation, aneurysm characteristics, treatment details, and perioperative events. Follow-up data included degree of aneurysm occlusion and delayed (> 30 days after the procedure) complications.RESULTSA total of 54 aneurysms were treated, with the same number of PulseRider devices, across 13 centers. Fourteen cases were in off-label locations (7 anterior communicating artery, 6 middle cerebral artery, and 1 A1 segment anterior cerebral artery aneurysms). The average dome/neck ratio was 1.2. Technical success was achieved in 52 cases (96.2%). Major complications included the following: 3 procedure-related posterior cerebral artery strokes, a device-related intraoperative aneurysm rupture, and a delayed device thrombosis. Immediately postoperative Raymond-Roy occlusion classification (RROC) class 1 was achieved in 21 cases (40.3%), class 2 in 15 (28.8%), and class 3 in 16 cases (30.7%). Additional devices were used in 3 aneurysms. For those patients with 3- or 6-month angiographic follow-up (28 patients), 18 aneurysms (64.2%) were RROC class 1 and 8 (28.5%) were RROC class 2.CONCLUSIONSPulseRider is being used in both on- and off-label cases following FDA approval. The clinical and radiographic outcomes are comparable in real-world experience to the outcomes observed in earlier studies. Further experience is needed with the device to determine its role in the neurointerventionalist’s armamentarium, especially with regard to its off-label use.
External retrospective validation of Brain Injury Guidelines criteria and modified guidelines for improved care value in the management of patients with low-risk neurotrauma
Authors: Ross Miner , Pang Priscilla S. , Raslan Ahmed M. , Selden Nathan R. , Cetas Justin S. 
Published: December 2019

OBJECTIVEConventional management of patients with neurotrauma frequently consists of routine, repeat head CT at preordained intervals with ICU-level monitoring, regardless of injury severity. The Brain Injury Guidelines (BIG) are a classification tool for stratifying patients into injury severity and risk-of-progression categories based on presenting clinical and radiographic findings. In the present study, the authors aimed to validate BIG criteria at a single level 1 trauma center.METHODSPatients were classified according to BIG criteria and evaluated for subsequent radiographic progression or development of neurological decline. A 2-year retrospective cohort review of consecutive patients with neurotrauma (n = 590) was undertaken. The authors then developed a modified BIG algorithm for use at their institution and followed its implementation prospectively over 555 consecutive patients.RESULTSIn the retrospective analysis, no patient in the BIG 1 category (n = 88, 14.9%) demonstrated progression or neurological decline, and 7.5% of BIG 2 patients (n = 107, 18.1%) demonstrated mild radiographic progression without any decline or need for additional neurosurgical or medical intervention, whereas 15.4% of BIG 3 patients (n = 395, 66.9%) underwent additional neurosurgical procedures. In the prospective analysis, no BIG 1 (n = 105, 18.9%) or BIG 2 (n = 48, 8.6%) patients demonstrated a clinical decline or required any further neurosurgical intervention. By contrast, 12.9% of BIG 3 patients (n = 402, 72%) required immediate neurosurgical intervention, and a further 2.0% required delayed intervention based on clinical and/or radiographic evidence of injury progression.CONCLUSIONSApplication of the BIG criteria in a single large level 1 trauma center reliably sorted patients into appropriate risk categories that accurately guided ongoing management.
The side door and front door to the upper retroclival region: a comparative analysis of the open pretemporal and the endoscopic endonasal transcavernous approaches
Authors: Labib Mohamed A. , Borba Moreira Leandro , Zhao Xiaochun , Gandhi Sirin , Cavallo Claudio , Tayebi Meybodi Ali , Youssef A. Samy , Little Andrew S. , Nakaji Peter , Preul Mark C. , Lawton Michael T. 
Published: December 2019

OBJECTIVEThe pretemporal transcavernous approach (PTA) and the endoscopic endonasal transcavernous approach (EETA) are both used to access the retroclival region. A direct quantitative comparison of both approaches has not been made. The authors compared the technical nuances of, and surgical exposure afforded by, each approach and identified the key elements of the approach selection process.METHODSFourteen cadaveric specimens underwent either PTA (group A) or EETA with unilateral (group B) followed by bilateral (group C) interdural pituitary gland transposition. The percentage of drilled clivus; length of exposed oculomotor nerve (cranial nerve [CN] III), posterior cerebral artery (PCA), and superior cerebellar artery (SCA); and surgical area of exposure of both cerebral peduncles and the pons for the 3 groups were measured and compared.RESULTSGroup A had a significantly lower percentage of drilled area than group B (mean [SD], 35.6% [11.2%] vs 91.3% [4.9%], p < 0.01). In group C, 100% of the upper third of the clivus was drilled in all specimens. Significantly longer segments of the ipsilateral PCA (p < 0.01) and SCA (p < 0.01) were exposed in group A than in group B. There was no significant difference in the length of the ipsilateral CN III exposed among the 3 groups. There was also no significant difference between group A and either group B or group C for the contralateral CN III or PCA exposure. However, longer segments of the contralateral SCA were exposed in group C than in group A (p = 0.02). Furthermore, longer segments of CN III (p < 0.01), PCA (p < 0.01), and SCA (p < 0.01) were exposed in group C than in group B. For brainstem exposure, there was greater exposure of the pons in group C than in group A (mean [SD], 211.4 [19.5] mm2 vs 157.7 [25.3] mm2, p < 0.01) and group B (211.4 [19.5] mm2 vs 153.9 [34.1] mm2, p < 0.01). However, significantly greater exposure of the ipsilateral peduncle was observed in group A (mean [SD], 125.6 [43.1] mm2) than in groups B and C (56.3 [6.0] mm2, p < 0.01). Group C had significantly greater exposure of the contralateral peduncle than group B (p = 0.02).CONCLUSIONSThis study is the first to quantitatively identify the advantages and limitations of the PTA and EETA from an anatomical perspective. Understanding these data may help the skull base surgeon design a maximally effective yet minimally invasive approach to individual lesions.
Pupillary changes after clinically asymptomatic high-acceleration head impacts in high school football athletes
Authors: Joseph Jacob R. , Swallow Jennylee S. , Willsey Kylene , Almeida Andrea A. , Lorincz Matthew T. , Fraumann Robert K. , Oppenlander Mark E. , Szerlip Nicholas J. , Broglio Steven P. 
Published: December 2019

OBJECTIVEPrevious studies have shown that clinically asymptomatic high-acceleration head impacts (HHIs) may be associated with neuronal and axonal injury, as measured by advanced imaging and biomarkers. Unfortunately, these methods of measurement are time-consuming, invasive, and costly. A quick noninvasive measurement tool is needed to aid studies of head injury and its biological impact. Quantitative pupillometry is a potential objective, rapid, noninvasive measurement tool that may be used to assess the neurological effects of HHIs. In this study, the authors investigated the effect of HHIs on pupillary metrics, as measured using a pupillometer, in the absence of a diagnosed concussion.METHODSA prospective observational cohort study involving 18 high school football athletes was performed. These athletes were monitored for both the frequency and magnitude of head impacts that they sustained throughout a playing season by using the Head Impact Telemetry System. An HHI was defined as an impact exceeding 95g linear acceleration and 3760 rad/sec2 rotational acceleration. Pupillary assessments were performed at baseline, midseason, after occurrence of an HHI, and at the end of the season by using the NeurOptics NPi-200 pupillometer. The Sport Concussion Assessment Tool, 5th Edition (SCAT5), was also used at each time point. Comparisons of data obtained at the various time points were calculated using a repeated-measures analysis of variance and a t-test.RESULTSSeven athletes sustained HHIs without a related diagnosed concussion. Following these HHIs, the athletes demonstrated decreases in pupil dilation velocity (mean difference 0.139 mm/sec; p = 0.048), percent change in pupil diameter (mean difference 3.643%; p = 0.002), and maximum constriction velocity (mean difference 0.744 mm/sec; p = 0.010), compared to measurements obtained at the athletes’ own midseason evaluations. No significant changes occurred between the SCAT5 subtest scores calculated at midseason and those after a high impact, although the effect sizes (Cohen’s d) on individual components ranged from 0.41 to 0.65.CONCLUSIONSMeasurable changes in pupil response were demonstrated following an HHI. These results suggest that clinically asymptomatic HHIs may affect brain reflex pathways, reflecting a biological injury previously seen when more invasive methods were applied.
Pituitary gland recovery following fully endoscopic transsphenoidal surgery for nonfunctioning pituitary adenoma: results of a prospective multicenter study
Authors: Little Andrew S. , Gardner Paul A. , Fernandez-Miranda Juan C. , Chicoine Michael R. , Barkhoudarian Garni , Prevedello Daniel M. , Yuen Kevin C. J. , Kelly Daniel F. , _ _ 
Published: December 2019

OBJECTIVERecovery from preexisting hypopituitarism after transsphenoidal surgery for pituitary adenoma is an important outcome to investigate. Furthermore, pituitary function has not been thoroughly evaluated after fully endoscopic surgery, and benchmark outcomes have not been clearly established. Here, the authors characterize pituitary gland outcomes with a focus on gland recovery following endoscopic transsphenoidal removal of clinically nonfunctioning adenomas.METHODSThis multicenter prospective study was conducted at 6 US pituitary centers among adult patients with nonfunctioning pituitary macroadenomas who had undergone endoscopic endonasal pituitary surgery. Pituitary gland function was evaluated 6 months after surgery.RESULTSThe 177 enrolled patients underwent fully endoscopic transsphenoidal surgery; 169 (95.5%) of them were available for follow-up. Ninety-five (56.2%) of the 169 patients had had a preoperative deficiency in at least one hormone axis, and 20/95 (21.1%) experienced recovery in at least one axis at the 6-month follow-up. Patients with adrenal insufficiency were more likely to recover (10/34 [29.4%]) than were those with hypothyroidism (8/72 [11.1%]) or male hypogonadism (5/50 [10.0%]). At the 6-month follow-up, 14/145 (9.7%) patients had developed at least one new deficiency. The study did not identify any predictors of gland recovery (p ≥ 0.20). Permanent diabetes insipidus was observed in 4/166 (2.4%) patients. Predictors of new gland dysfunction included a larger tumor size (p = 0.009) and Knosp grade 3 and 4 (p = 0.051).CONCLUSIONSFully endoscopic pituitary surgery resulted in improvement of pituitary gland function in a substantial minority of patients. The deficiency from which patients were most likely to recover was adrenal insufficiency. Overall rates of postoperative permanent diabetes insipidus were low. This study provides multicenter benchmark neuroendocrine clinical outcome data for the endoscopic technique.