bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model of Prophylactic Efficiency of Influenza Virus Vaccine Corrected to the Antigenic Distance Hypothesis
Authors: Kolesin I. D. , Zhitkova E. M. 
Published: March 2020

The aim of the study is to find a quantitative relationship between antigenic distances (AD) and vaccination effectiveness (VE) and investigate the response of VE to changes in AD.Material and methods. Through the epidemiological data of three influenza seasons in Canada, interpreted within the framework of the antigenic distance hypothesis (ADH), the introduction of the correction factor into the model for estimating VE was substantiated considering the antigenic relationship between the previous season vaccine (V1), the current season vaccine (V2) and the circulating epidemic strain (e).Results. A quantitative relationship between VE and AD was found, reproducing the results of epidemiological observation of two groups of people: vaccinated in the previous and current seasons (V1+V2) and vaccinated only in the current season (0+V2). The difference in the response of VE to different indicators of AD was found and allowing to use only one significant indicator.Conclusion. Тhe model proposed relates the microbiological indicators AD with epidemiological characteristic of VE. The model extends the analysis, allowing to use it as an assessment tool for the expected changes in vaccine effectiveness in various settings of the ADH hypothesis experiment.
Effect of Rabbit Immunization with Yeast Antigens on the Activity of the Fraction of Serum Antimicrobial Peptides
Authors: Arzumanian V. G. , Iksanova A. M. , Artemyeva T. A. , Butovchenko L. M. 
Published: March 2020

The aim was to study the effect of rabbit immunization with different yeasts cells on overall antimicrobial serum activity and specific activity of antimicrobial peptides fraction.Material and methods. Rabbits were immunized with cells of Candida albicans, Rhodotorula mucilaginosa, Malassezia furfur, Cryptococcus neoformans, Geotrichum candidum, Trichosporon cutaneum and Saccharomyces cerevisiae. AMP fractions were obtained by filtration through 100 kDa filters. Overall activities of sera and their AMP-fractions were estimated spectrophotometrically.Results. Overall serum antimicrobial activity had tendency to decrease after immunization independently from yeast species. Activity of AMP-fractions after immunization with C. albicans, Cr. neoformans, G. candi dum и S. ce revisiae increased, but with other yeasts — decreased. The highest sensitivity to AMP fraction cor res ponded to C. albicans, especially for serum of the rabbit immunized with this yeasts — 1,5-fold higher com pare to control. Serum albumin concentration showed the positive correlation with overall antimicrobial activity against C. albicans (r = 0,760), R. mucilaginosa (r = 0,728), M. furfur (r = 0,723) и T. cutaneum (r = 0,588).Discussion. The results confirm our earlier data. Moreover, they expand current views on the effect of yeasts antigens on activity of serum AMP against different yeasts.Conclusion. Serum albumin and serum AMP demonstrated the specificity toward different yeasts: maximal activity they showed towards specia which more often play opportunistic role.
Etiological and Epidemiological Characteristics of Lethality from Acute Viral Hepatitis, Kyrgyzstan, 2009−2018
Authors: Nogoibaeva К. A. , Tobokalova S. T. 
Published: March 2020

Purpose. Study of the etiological structure of lethality from acute viral hepatitis and its comparison with morbidity and mortality for the period of 2009−2018.Materials and methods. State Reporting Forms No. 1 “Report on Infectious, Parasitic and Non-Infectious Diseases” for the period of 2009−2018 were studied. The data was processed by the Microsoft Office Excel statistical package.Results. In Kyrgyzstan, during the period of 2009−2018, 138,612 cases of acute viral hepatitis (AVH) were detected, of which 109 patients had fatal outcomes. In the general structure of the latter, the proportions of patients with acute hepatitis B (AHB 36.7%) and A (AHA, 35.7%) were approximately the same. In every fifth case, “unverified acute viral hepatitis (UAVH)” was diagnosed (22.9%). Acute hepatitis C (AHC) was the cause of death in 4 patients (3%), and hepatitis D virus (HDV) infection in 1 patient. Among the deceased, there were no cases of hepatitis E. Lethality from AHB was recorded in 5 children, and from hepatitis C in one child. At the same time, 9 out of 25 patients with “Unverified Acute Viral Hepatitis” were children. Over the period of 2009−2018, the incidence of AHB was 31.3 times lower than that of all AVH in general (240.9 and 7.7⁰/0000, AVH and AHB, respectively), the mortality rate was 2.7 times lower (0.19 and 0.07⁰/0000, AVH and AHB, respectively), and the lethality rate was 11.4 times higher (7.9 and 89.8⁰/0000, AVH and AHB, respectively). The average incidence of AHB in children was 6.4 times lower (7.7 and 1.2⁰/0000, total and children, respectively), the mortality rate was 2.3 times lower (0.07 and 0.03⁰/0000, total and children, respectively), and the lethality rate was 1.8 times higher (89.8 and 165.9⁰/0000, total and children, respectively).Conclusion. The existence of morbidity and lethality in adults and children from acute hepatitis indicates a high disease burden for the country. The high proportion of AHB and AHA in the structure of AVH mortality requires improving the quality of immunization of children and expanding the coverage of adults with vaccination against these viral hepatitis. The increase in lethality against the background of a tenfold decrease in the incidence of AVH points out that the number of patients who have died from this pathology does not decrease.
Kajian Karakteristik Fisik Dan Mekanik Pastefill Yang Digunakan Pada Penambangan Emas Bawah Tanah Metode Cut And Fill Di PT. Nusa Halmahera Minerals–Gosowong Halmahera
Authors: Karim Razak , Kusrima Anita 
Published: March 2020

PT. Nusa Halmahera Minerals (NHM) merupakan perusahaan pertambangan emas yang beroperasi di daerah Kencana Gosowong Desa Tabobo Kecamatan Malifut Kabupaten Halmahera Utara Provinsi Maluku Utara. Dari hasil evaluasi, metode Underhand Cut and Fill (UCF) dipilih karena beberapa pertimbangan ; cash flow rendah, recovery tinggi, dan lebih aman saat berhadapan dengan kondisi batuan yang buruk. Namun permasalahan yang dihadapi adalah mengenai kekuatan material backfill jenis pastefill yang digunakan untuk bertindak sebagai atap dan dinding terowongan produksi bagi para pekerja dan peralatan yang berada disekitarnya. Kajian sifat fisik dan mekanik pastefill ini dilakukan berdasarkan hasil pengujian di Laboratorium Geomekanika Puslitbang Tekmira Kementerian ESDM di Bandung. Penelitian ini dilakukan untuk mendukung kekuatan fisik dan mekanik pastefill yang digunakan untukmengisi ruang- ruang kosong pada terowongan produksi setelah pengambilan bijih emas. Hasil uji sifat fisik vulkanik tuff terlihat adanya peningkatan bobot isi dari kondisi kering ke kondisi jenuh rata-rata 0,17gr/cm3. Kadar air pun mengalami peningkatan dari kondisi natural ke kondisi jenuh rata-rata 20.82%, hal ini dikarenakan jumlah air yang masuk ke dalam pori-pori meningkat. Banyaknya kadar air asli rata-ratasebesar 23,83% dan kadar air jenuh rata-rata 44.65%, derajat kejenuhan berkisar 14.74–91.2% serta nilai porositasnya 38.12–43.94% dan angka pori rata-rata 0.7. Penggunaan pastefill untuk mengisi ruang-ruang kosong (stope) pada tambang emas bawah tanah Kencana harus dirancang dengan nilai c berkisar 0.5–2 MPa, t berkisar 0.05–0.2 MPa, kohesi (c) berkisar 0.07–0.3 MPa dan sudut gesek dalam (ϕ) berkisar300–450, sebagai persyaratan sifat mekanik untuk melakukan penambangan bijih disamping dinding pastefill harus memenuhi UCS minimal 0.5 MPa, sedangkan penambangan dibawah pastefill, UCSminimal 1.2 MPa. Blok pastefill di dalam stope yang diinterpretasi dari hasil uji diperoleh kondisi stabil untuk dilakukan penambangan dengan pastefill sebagai dinding terowongan yaitu kandungan semen 6%pada umur 14 hari, kandungan semen 12% pada umur 7 hari, dan kandungan semen 14% pada umur 3 hari. Sedangkan jika penambangan dilakukan dibawah pastefill atau sebagai atap terowongan menunjukkan kondisi tidak stabil kecuali persentase kandungan semen 14% pada umur 28 hari akan stabil, artinya penambangan dapat dilakukan pada umur pastefill antara 21-28 hari dengan diberi perkuatan. Desain sifat mekanik pastefill disesuaikan dengan rencana penambangan, jika sikluspenambangan membutuhkan waktu yang sangat cepat maka persentase semen akan dinaikkan, dan jika siklus penambangannya membutuhkan waktu yang lama, maka persentase semen akan dikurangi denganmenunggu umur pastefill mencapai kekuatan dan faktor keamanan yang dipersyaratkan untuk melakukan penambangan berikutnya, baik disamping maupun dibawahnya.
Pengaruh Pijat Bayi Terhadap Lama Tidur Bayi Usia 3-6 Bulan di Desa Jemawan Kecamatan Jatinom Kabupaten Klaten
Authors: Istikhomah Henik 
Published: March 2020

Background: Sleep is prime priority for baby, because when this moment occurs repair neuro-brain and more or less 75% of growth hormone are produced. Considering the importance of sleep time for baby development, baby’s sleep needs must be fulfilled in order not to adversely affect growth and development. One of the way to fulfill baby’s sleep needs is baby massage. When baby massaged will increase serotonin secretion that will suppress the activity of the reticulation-activating system and causing sleepy. Purpose this study to knowing the effect of baby massage to the length of sleep of baby ages 3-6 month in Jemawan Village, Jatinom Sub-District, Klaten District. Methods: Quasy eksperiment research with one group pretest-posttest design. Sampling using saturated sampling technique with 32 babies. Bivariate analysis using non parametric statistic Wilcoxon test with an error rate of 5%. Baby massage is performed of baby ages 3-6 month throughout the baby’s body for 30 minutes, baby massage is doing 2 times a week in 4 weeks.Results: This study show results that the length of sleep of baby before doing massage is mostly less than 13 hours as much as 18 babies (56,25%) and the length of sleep of baby after doing massage is normal 13-15 hours as much as 27 babies (84,38%). The result of Wilcoxon test is p = 0,000 (p <0,05) that Ha accepted.Conclusion: There is effect of baby massage to the length of sleep of baby ages 3-6 month in Jemawan Village, Jatinom Sub-District, Klaten District.
FEATURES OF A DIFFERENTIAL DIAGNOSIS OF PEDIATRIC ACUTE MONOCYTIC LEUKEMIA (AML-M5a) ON THE EXAMPLE OF A CLINICAL CASE
Authors: Kit O. I. , Guskova N. K. , Selyutina O. N. , Dmitrieva V. V. , Novikova I. A. , Torpujyan I. S. , Zakharchenko V. R. 
Published: March 2020

The aim of this work was to assess the significance of investigating clinical and laboratory parameters for diagnosing acute monocytic leukemia in children on the basis of a clinical case. The article demonstrates specific features of differentiating AML M5a from other forms of acute myeloid leukemia. According to the results of hematological, morphological and cytofluorimetric studies of blood and bone marrow samples, the diagnosis of acute myeloid leukemia was established. The morphological and phenotypic characteristics of blast cells hampered the diagnosis of an AML form. However, a comprehensive analysis of the expressed CD antigens allowed acute monocytic leukemia to be identified, which diagnosis was subsequently confirmed by a cytochemical study. Thus, the clinical diagnosis was established over a short period of time. This was of importance given the rising severity of the patient’s condition requiring immediate treatment, the initial hyperleukocytosis and the development of life-threatening complications associated with leukostasis in the lungs and the central nervous system. In the presented case, the clinical manifestations of the underlying disease and the results of flow cytofluorimetry were determining factors in initiating timely specific therapy.
IBM Karang Taruna Petungsewu: Revitalisasi Organisasi
Authors: Sad Windu Wisnu Broto Felik 
Published: March 2020

Karang Taruna Desa Petungsewu adalah salah satu organisasi kepemudaan yang ada di desa Petungsewu, yang baru saja dihidupkan kembali setelah sekian puluh tahun vakum, atau tidak hidup. Keberadaan Karang Taruna desa Petungsewu tak lepas dari tuntutan undang-undang desa. Sejak undang-undang desa diberlakukan, aparat desa mulai bergerilya mencari orang muda desa untuk diajak menghidupkan kembali Karang Taruna tingkat desa. Akhirnya terkumpulah puluhan pemuda yang siap untuk menghidupkan kembali organisasi Karang Taruna. Persoalannya, puluhan pemuda yang terkumpul ini berasal dari berbagai latar belakang pendidikan yang berbeda, mulai dari lulusan SD, SMP sampai SMA. Dan mereka belum pernah berorganisasi sebelumnya. Atas persoalan inilah revitalisasi organisasi mendesak untuk dilakukan. Program pengabdian dilakukan untuk membantu anggota Karang Taruna memahami apa itu organisasi. Apa saja yang harus dilakukan anggota dalam organisasi? Bagaimana menyusun visi dan misi organisasi? Bagaimana membuat struktur organisasi dengan pembagian tugasnya? Dan akhirnya bagaimana menyusun manajemen organisasi? Dalam pengabdian ini telah dilakukan pembinaan selama enam kali secara formal dan delapan kali informal melalui kunjungan dan pendampingan. Produk yang telah dihasilkan adalah visi dan misi, struktur kepengurusan dan tugas masing-masing, serta kemampuan anggota untuk berkomunikasi.
Program Pengembangan Kewirausahaan Bagi Mahasiswa Dan Alumni Unika Widya Mandala Madiun
Authors: Agustini Srimulyani Veronika , Rustiyaningsih Sri , Ariyani Vivi , Anang Setiyo Waluyo Lorensius 
Published: March 2020

Tujuan jangka pendek dan menengah dari PPK (Program Pengembangan Kewirausahaan) di Universitas
Katolik Widya Mandala Madiun (WIMA) adalah menumbuhkan budaya kewirausahaan di WIMA melalui kegiatan memotivasi dan menumbuhkan mindset tenant, melatih (workshop/pelatihan kewirausahaan), kunjungan industri, mendampingi, agar tenant mendapatkan dan memiliki keahlian dan ketrampilan berwirausaha agar tenant memiliki keberanian untuk menjadi wirausaha dan berhasil menjadi wirausaha baru yang mandiri dan berkelanjutan, berwawasan knowledge based economy. Tujuan jangka panjang pendek dari PPK di WIMA menghasilkan wirausahawan diri profesional, tangguh dan humanis, membuka lapangan kerja, sehingga diharapkan akan berdiri unit usaha di WIMA dan di luar WIMA. Metode pelaksanaan PPK di WIMA dengan tahapan (1)fase penyadaran awareness (2) fase entrepreneurship capacity building dan (3) fase institutionalization usaha baru. Fase awareness dilakukan melalui recruitment test dan pelaksanaan perkuliahan, tes potensi kewirausahaan dan tes kepribadian, dan/atau seminar kewirausahaan (entrepreneurship). Fase capaciting meliputi: pelatihan penulisan business plan, diklat kewirausahaan, success story, kunjungan ke mitra industri, pelatihan pembibitan ikan lele, pelatihan pembuatan batik ikat celup (tie dye), pelatihan manajemen usaha, fasilitasi pameran produk, pembimbingan/pendampingan usaha, dialog interaktif kewirausahaan, fasilitasi pameran produk, dan pembuatan website usaha. Fase institutionalization usaha baru berupa pendampingan usaha, pemberian dana bantuan peralatan penunjang/usaha, pengawasan, evaluasi, dan penyelesaian masalah yang dihadapi tenant.
On the Origin of High-energy Neutrinos from NGC 1068: The Role of Nonthermal Coronal Activity
Authors: Inoue Yoshiyuki , Khangulyan Dmitry , Doi Akihiro 
Published: March 2020

Abstract
NGC 1068, a nearby type-2 Seyfert galaxy, is reported as the hottest neutrino spot in the 10 yr survey data of IceCube. Although there are several different possibilities for the generation of high-energy neutrinos in astrophysical sources, feasible scenarios allowing such emission in NGC 1068 have not yet been firmly defined. We show that the flux level of GeV and neutrino emission observed from NGC 1068 implies that the neutrino emission can be produced only in the vicinity of the supermassive black hole in the center of the galaxy. The coronal parameters, such as magnetic field strength and corona size, that make this emission possible, are consistent with the spectral excess registered in the millimeter range. The suggested model and relevant physical parameters are similar to those revealed for several nearby Seyferts. Due to the internal gamma-ray attenuation, the suggested scenario cannot be verified by observations of NGC 1068 in the GeV and TeV gamma-ray energy bands. However, the optical depth is expected to become negligible for MeV gamma-rays, thus future observations in this band will be able to validate our model.
A Rapid Change in X-Ray Variability and a Jet Ejection in the Black Hole Transient MAXI J1820+070
Authors: Homan Jeroen , Bright Joe , Motta Sara E. , Altamirano Diego , Arzoumanian Zaven , Basak Arkadip , Belloni Tomaso M. , Cackett Edward M. , Fender Rob , Gendreau Keith C. , Kara Erin , Pasham Dheeraj R. , Remillard Ronald A. , Steiner James F. , Stevens Abigail L. , Uttley Phil 
Published: March 2020

Abstract
We present Neutron Star Interior Composition Explorer X-ray and Arcminute Microkelvin Imager Large Array radio observations of a rapid hard-to-soft state transition in the black hole X-ray transient MAXI J1820+070. During the transition from the hard state to the soft state a switch between two particular types of quasiperiodic oscillations (QPOs) was seen in the X-ray power density spectra, from type-C to type-B, along with a drop in the strength of the broadband X-ray variability and a brief flare in the 7–12 keV band. Soon after this switch (∼2–2.5 hr) a strong radio flare was observed that corresponded to the launch of superluminal ejecta. Although hints of a connection between QPO transitions and radio flares have been seen in other black hole X-ray transients, our observations constitute the strongest observational evidence to date for a link between the appearance of type-B QPOs and the launch of discrete jet ejections.
Interventions Within the Scope of Occupational Therapy Practice to Improve Activities of Daily Living, Rest, and Sleep for Children Ages 0–5 Years and Their Families: A Systematic Review
Authors: Gronski Meredith , Doherty Meghan 
Published: March 2020

Abstract
Importance: Research studies supporting occupational therapy interventions to address feeding, toileting, and sleep can be applied to practice in early intervention and preschool settings to improve the outcomes of young children and their families.
Objective: To examine the effectiveness of interventions within the scope of occupational therapy practice to improve activities of daily living, rest, and sleep for children ages 0–5 yr and their families.
Data Sources: Five databases (MEDLINE, PsycINFO, CINAHL, OTseeker, ERIC) and Evidence-Based Medicine Reviews, Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, and Database of Abstracts of Reviews of Effectiveness were searched for studies published between January 2000 and March 2017.
Study Selection and Data Collection: Inclusion criteria were Levels I–III evidence, being within occupational therapy’s scope of practice, including participants with a mean age younger than 6 yr, and addressing self-care, activities of daily living, and rest and sleep.
Findings: Forty articles were appraised, and three themes emerged: interventions to address feeding and eating, interventions to address toileting, and interventions to address rest and sleep. Additional subthemes of behavioral approaches, parent and caregiver education, and contextual intervention were revealed.
Conclusions and Relevance: Occupational therapy practitioners should consider the use of interventions with moderate or strong evidence as described in this review. Limitations include risk of bias and limited evidence for several interventions.
What This Article Adds: This article provides a broader perspective on evidence-based practice by examining studies within the scope of occupational therapy practice published outside of current occupational therapy publications. The review includes studies from nutrition, nursing, and psychology, which address interdisciplinary care, family coaching and education, and behavioral approaches within the professional scope of occupational therapy to improve the functional performance, routines, and quality of life for young children and their caregivers.
Scattering matrices of mineral dust aerosols: a refinement of the refractive index impact
Authors: Huang Yifan , Liu Chao , Yao Bin , Yin Yan , Bi Lei 
Published: March 2020

Abstract. Mineral dust, as one of the most important aerosols, plays a crucial role in the atmosphere by directly interacting with radiation, while there are
significant uncertainties in determining dust optical properties to quantify radiative effects and to retrieve their properties. Laboratory and in
situ measurements of the refractive indices (RIs) of dust differ, and different RIs have been applied in numerical studies used
for model developments, aerosol retrievals, and radiative forcing simulations. This study reveals the importance of the dust RI for the
development of a model of dust optical properties. The Koch-fractal polyhedron is used as the modeled geometry, and the pseudospectral time domain
method and improved geometric-optics method are combined for optical property simulations over the complete size range. We find that the scattering
matrix elements of different kinds of dust particles are reasonably reproduced by choosing appropriate RIs, even when using a fixed
particle geometry. The uncertainty of the RI would greatly affect the determination of the geometric model, as a change in the RI,
even in the widely accepted RI range, strongly affects the shape parameters used to reproduce the measured dust scattering matrix
elements. A further comparison shows that the RI influences the scattering matrix elements in a different way than geometric factors, and,
more specifically, the P11, P12, and P22 elements seem more sensitive to the RI of dust. In summary, more efforts should be devoted
to account for the uncertainties on the dust RI in modeling its optical properties, and the development of corresponding optical models can
potentially be simplified by considering only variations over different RIs. Considerably more research, especially from direct
measurements, should be carried out to better constrain the uncertainties related to the dust aerosol RIs.