bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of traumatic events with levels of psychological distress and depressive symptoms in male asylum seekers and refugees resettled in Italy
Authors: Nosè Michela , Tarsitani Lorenzo , Tedeschi Federico , Lotito Claudia , Massetti Paola , Purgato Marianna , Roselli Valentina , Todini Liliana , Turrini Giulia , Barbui Corrado 
Published: December 2020

Abstract
Background
In recent years there has been a progressive rise in the number of asylum seekers and refugees displaced from their country of origin, with significant social, economic, public health and mental health implications. The aim of this study is to (1) describe the level of psychological distress and frequency of psychiatric disorders in a sample of male asylum seekers and refugees across different ethnic groups resettled in Italy; (2) establish whether the number of traumatic events experienced before, during and after the migration process is associated with level of psychological distress and depressive symptoms.

Methods
In two large Italian catchment areas, over a period of 1 year a consecutive series of male asylum seekers and refugees, aged 18 or above and included in the Italian protection system, were screened for psychological distress and psychiatric disorders using validated questionnaires.

Results
During the study period, 252 male asylum seekers or refugees were recruited. More than one-third of the participants (34.5%) showed clinically relevant psychological distress, and one-fourth (22.2%), met the criteria for a psychiatric diagnosis, mainly Post Traumatic Stress Disorder and depressive disorders. The number of traumatic events turned out to be a risk factor for both clinically relevant psychological distress and depressive disorders. Receiving good social support emerged as a protective factor, while migrants with unclear status were at higher risk of psychological distress than those holding or awaiting a permission.

Discussion
In an unselected sample of male asylum seekers and refugees, after around 1 year of resettlement in Italy, the frequency of psychological distress and psychiatric disorders was substantial and clinically relevant. The association between traumatic events, especially post-migration problems, and mental health conditions suggests the need of developing services to assist refugees and asylum seekers to address the multi-faceted problems they experience, such as social support in host country, legal problems concerning permit status and asylum procedure, and family reunification, as well as addressing trauma and mental health issues.
Development and validation of a 25-Gene Panel urine test for prostate cancer diagnosis and potential treatment follow-up
Authors: Johnson Heather , Guo Jinan , Zhang Xuhui , Zhang Heqiu , Simoulis Athanasios , Wu Alan H. B. , Xia Taolin , Li Fei , Tan Wanlong , Johnson Allan , Dizeyi Nishtman , Abrahamsson Per-Anders , Kenner Lukas , Feng Xiaoyan , Zou Chang , Xiao Kefeng , Persson Jenny L. , Chen Lingwu 
Published: December 2020

Abstract
Background
Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecessary biopsies.

Methods
Using a machine learning program, we identified a 25-Gene Panel classifier for distinguishing PCa and benign prostate. A non-invasive test using pre-biopsy urine samples collected without digital rectal examination (DRE) was used to measure gene expression of the panel using cDNA preamplification followed by real-time qRT-PCR. The 25-Gene Panel urine test was validated in independent multi-center retrospective and prospective studies. The diagnostic performance of the test was assessed against the pathological diagnosis from biopsy by discriminant analysis. Uni- and multivariate logistic regression analysis was performed to assess its diagnostic improvement over PSA and risk factors. In addition, the 25-Gene Panel urine test was used to identify clinically significant PCa. Furthermore, the 25-Gene Panel urine test was assessed in a subset of patients to examine if cancer was detected after prostatectomy.

Results
The 25-Gene Panel urine test accurately detected cancer and benign prostate with AUC of 0.946 (95% CI 0.963–0.929) in the retrospective cohort (n = 614), AUC of 0.901 (0.929–0.873) in the prospective cohort (n = 396), and AUC of 0.936 (0.956–0.916) in the large combination cohort (n = 1010). It greatly improved diagnostic accuracy over PSA and risk factors (p < 0.0001). When it was combined with PSA, the AUC increased to 0.961 (0.980–0.942). Importantly, the 25-Gene Panel urine test was able to accurately identify clinically significant and insignificant PCa with AUC of 0.928 (95% CI 0.947–0.909) in the combination cohort (n = 727). In addition, it was able to show the absence of cancer after prostatectomy with high accuracy.

Conclusions
The 25-Gene Panel urine test is the first highly accurate and non-invasive liquid biopsy method without DRE for PCa diagnosis. In clinical practice, it may be used for identifying patients in need of biopsy for cancer diagnosis and patients with clinically significant cancer for immediate treatment, and potentially assisting cancer treatment follow-up.
Feasibility, safety, and resource utilisation of active mobilisation of patients on extracorporeal life support: a prospective observational study
Authors: Braune Stephan , Bojes Patrick , Mecklenburg Anne , Angriman Federico , Soeffker Gerold , Warnke Katja , Westermann Dirk , Blankenberg Stefan , Kubik Mathias , Reichenspurner Hermann , Kluge Stefan 
Published: December 2020

Abstract
Background
There is scarce evidence on the feasibility, safety and resource utilisation of active mobilisation in critically ill patients on extracorporeal life support (ECLS).

Methods
This prospective observational single-centre study included all consecutive critically ill patients on ECLS admitted to an academic centre in Germany over a time period of one year. The level of mobilisation was categorised according to the ICU Mobility Scale (IMS). Primary outcome was complications during mobilisation.

Results
During the study period, active mobilisation with an activity level on the IMS of ≥ 3 was performed at least on one occasion in 43 out of 115 patients (37.4%). A total of 332 mobilisations with IMS ≥ 3 were performed during 1242 ECLS days (26.7%). ECLS configurations applied were va-ECMO (n = 63), vv-ECMO (n = 26), vv-ECCO2R (n = 12), av-ECCO2R (n = 10), and RVAD (n = 4). Femoral cannulation had been in place in 108 patients (93.9%). The median duration of all mobilisation activities with IMS ≥ 3 was 130 min (IQR 44–215). All mobilisations were undertaken by a multi-professional ECLS team with a median number of 3 team members involved (IQR 3–4). Bleeding from cannulation site requiring transfusion and/or surgery occurred in 6.9% of actively mobilised patients and in 15.3% of non-mobilised patients. During one mobilisation episode, accidental femoral cannula displacement occurred with immediate and effective recannulation. Sedation was the major reason for non-mobilisation.

Conclusions
Active mobilisation (IMS ≥ 3) of ECLS patients undertaken by an experienced multi-professional team was feasible, and complications were infrequent and managed successfully. Larger prospective multicentre studies are needed to further evaluate early goal directed sedation and mobilisation bundles in patients on ECLS.
Central venous catheter-related bloodstream infection and colonization: the impact of insertion site and distribution of multidrug-resistant pathogens
Authors: Pitiriga Vassiliki , Kanellopoulos Petros , Bakalis Ioannis , Kampos Elsa , Sagris Ioannis , Saroglou George , Tsakris Athanasios 
Published: December 2020

Abstract
Background
Placement of central-venous catheters (CVCs) is an essential practice in the management of hospitalized patients, however, insertion at the commonly used sites has often the potential of inducing major complications. Neverthelss, the impact of specific site central line catheter insertion on catheter-associated bloodstream infections (CLABSIs) has not been clarified yet in the literature.

Objective
The aim of the study was to compare CLABSIs and catheter colonization rates among the three catheter insertion sites: subclavian (SC), internal jugular (IJ) and femoral (FEM) in hospitalized patients. Moreover, to analyze the distribution of pathogens and their antimicrobial resistance profiles at these three sites, concurrently.

Methods
We performed a retrospective analysis of data collected prospectively from all catheterized patients at a tertiary care Greek hospital from May 2016 to May 2018. Data was collected on 1414 CVCs and 13,054 CVC-days.

Results
Τhe incidence of CLABSIs among the three sites was as follows: SC:5.1/1000 catheter/days, IJ: 3.73/1000 catheter/days and FEM: 6.93/1000 catheter/days (p = 0.37). The incidence of colonization was as follows: SC:13.39/1000 catheter/days; IJ:7.34/ 1000 catheter/days; FEM:22.91/1000 catheter/days (p = 0.009). MDROs predominated in both CLABSIs and tip colonizations (59.3 and 61%, respectively) with Acinetobacter baumanii being the predominant pathogen (16/59, 27.1% and 44/144, 30.5%, respectively). The incidence of CLABSIs due to multidrug-resistant organisms (MDROs) was as follows: SC:3.83/1000 catheter days; IJ:1.49/1000 catheter days; FEM:5.86/1000 catheter days (p = 0.04). The incidence of tip colonization by MDROs among the 3 sites was as follows: SC:8.93/1000 catheter/days; IJ:4.48/1000 catheter/days; FEM:12.79/1000 catheter/days (p = 0.06). There was no significant difference in the type of pathogen isolated among site groups for both CLABSIs and tip colonizations.

Conclusions
FEM site of catheter insertion was associated with a higher rate of bloodstream infection and catheters’ colonization compared to IJ and SC sites. Furthermore, this survey highlights the changing trend of the distribution of frequent pathogens and resistance patterns towards MDR Gram-negative pathogens, underscoring the need for consistent monitoring of antimicrobial resistance patterns of these specific infections.
The stable component of maternal depressive symptoms predicts offspring emotional and behavioral symptoms: a 9-years longitudinal study
Authors: Cerniglia L. , Dentale F. , Tambelli R. , Murray L. , Cooper P. , Cimino S. 
Published: December 2020

Abstract
Background
Maternal sub-threshold and non-clinical depression and its possible outcomes on offspring internalizing/externalizing symptoms has received growing attention in recent years because of its significant worldwide prevalence.

Methods
Through a Latent State-Trait Analysis approach (LST), this longitudinal study aimed to identify a stable component of non-clinical maternal depression across a temporal interval of 6 years (measured through the Symptom Check-List-90/R) and to determine the effect of this component on children’s emotional and behavioral functioning (measured through the Child Behaviour Check-List) at age 12 years.

Results
LST analysis showed that maternal depressive symptoms tended to remain stable within individuals across 6 years of observation strongly contributing to children’s internalizing/externalizing and dysregulation symptoms.

Conclusions
The current longitudinal analysis of maternal and child data revealed that a stable component of maternal depressive symptoms reliably predicted a wide range of child emotional and behavioral symptoms at 12 years of age.
Importance of microhabitat selection by birds for the early recruitment of endangered trees in a fragmented forest
Authors: Li Ning , Wang Zheng , Cai Yao , Zhang Lin 
Published: December 2020

AbstractBackgroundRemnant microhabitats are important for bird habitat selection and plant regeneration in the fragmented habitat. However, empirical information on the consequences of how microhabitat use by birds affects the early recruitment of plants is lacking.MethodsIn this study, we evaluated whether microhabitat selection by the Black Bulbul (Hypsipetes leucocephalus) (J. F. Gmelin, 1789) impacts the early recruitment of the endangered tree species, the Chinese Yew (Taxus chinensis(Pilger) Rehd), in a fragmented forest over a 4-year period (2011–2012, 2018–2019).ResultsOur results showed the main factors affectingH. leucocephalusmicrohabitat selection were distance to the nearestT. chinensismature tree, herb cover and density, leaf litter cover, and vegetation type. Moreover, the results of logistic regression also highlighted the importance of elevation, distance to light gap and roads, tree cover in bird microhabitat selection. Furthermore, the seed emergence rate in microhabitats used by birds did not differ from the natural forest, which was related to five factors of bird microhabitat. The Random Forest model showed that seedling emergence rate was increased with leaf litter cover and distance to fallen dead trees, but decreased in relation to herb cover, slope, and elevation.ConclusionOur results highlight the importance of remnant microhabitats in fragmented forests for sustaining forest ecology and optimal management. The contribution of microhabitats used by birds to plant recruitment provides insights into how frugivore species contribute to plant regeneration, which should be incorporated in future conservation and management practices of fragmented forests.
The associations of lens power with age, axial length and type 2 diabetes mellitus in Chinese adults aged 50 and above
Authors: Ye Luyao , He Jiangnan , Zhang Xinji , Xu Yi , Chen Qiuying , Yin Yao , Fan Ying , Lu Lina , Zhu Jianfeng , Zou Haidong , Xu Xun 
Published: December 2020

Abstract
Background
To investigate the associations of lens power with age, axial length (AL), and Type 2 diabetes mellitus (DM) in Chinese adults aged 50 and above.

Methods
Random clustering sampling was used to identify adults aged 50 years and above in urban regions of Shanghai. The participants underwent a comprehensive ophthalmic examination including subjective refraction, autorefraction, and IOL-Master. The crystalline lens power was calculated using Bennett’s formula.

Results
A total of 4177 adults were included. A linear decrease in lens power was observed both with age and with AL, followed by a stop of lens power loss after the age of 70 or when AL ≥ 25 mm, respectively. Participants with Type 2 DM presented higher lens power (0.43 diopter (D), p < 0.001) and thicker lens thickness (0.06 mm, p < 0.001). In multivariate regression models, there was a positive correlation between lens power and Type 2 DM when age < 75 years (p < 0.001) or AL < 25 mm (p < 0.001) after adjusting for other factors, while no significant association was found in participants aged ≥ 75 years (p = 0.122) or with AL ≥ 25 mm (p = 0.172).

Conclusions
The lens power in adults aged 50 and above exhibited two stages with age and with AL. Type 2 DM caused an increase in lens power, which was not seen in participants aged ≥ 75 years or with AL ≥ 25 mm.
A feasibility study on two tailored interventions to improve adherence in adults with haemophilia
Authors: Hoefnagels J. W. , Fischer K. , Bos R. A. T. , Driessens M. H. E. , Meijer S. L. A. , Schutgens R. E. G. , Schrijvers L. H. 
Published: December 2020

AbstractIntroductionHaemophilia is a congenital bleeding disorder mainly affecting males. To prevent bleeding, patients need to perform regular intravenous injections (prophylaxis) throughout life. Non-adherence often occurs. Problems with acceptance or self-management appear to be the main reasons for non-adherence in haemophilia. The aim of this study was to test the feasibility and effects of two interventions focussed on acceptance (face-to-face) and self-management (online).MethodsPatients with severe haemophilia and acceptance or self-management problems were eligible. The face-to-face group intervention was based on Acceptance and Commitment Therapy (ACT) (8 sessions/6 months, targetN= 8 participants). The online intervention was based on a successful online programme in rheumatoid arthritis (5–8 modules/2 months, targetN= 8). Both interventions were designed according to the MRC framework in collaboration with the patient society and experts. We compared adherence (VERITAS-Pro, optimum 0), quality of life (SF-36, optimum 100) and illness perception (BIPQ, optimum 0) before start (T0) and after 2 months (T2). Feasibility criteria were as follows: completion of training by > 50% of participants and ability to collect at least 80% of outcome parameters.ResultsThe face-to-face intervention was feasible (89% enrolment and recruitment, 100% retention). One hundred percent of the outcome parameters was collected. Results were promising: although adherence (VERITAS-Pro) was stable (from 64 to 62 points), quality of life (SF-36) showed a clinically relevant improvement (> 5 points) in five of eight domains. Illness perception (BIPQ) showed a clinically relevant increase from 47 to 39 points. Patient evaluation was positive.The online intervention, however, was infeasible: enrolment was only 20% (6/30). Only three patients signed informed consent (recruitment 10%), and none completed more than one module (retention 0%). Consequently, the online intervention was terminated.ConclusionThe face-to-face acceptance intervention was considered feasible with promising results. Unfortunately, the online intervention was infeasible and therefore terminated. These findings suggest that adapting effective interventions to other settings does not guarantee success, despite the use of established methodology and patient participation. Population differences (only male participants, congenital disease) could be an explanation for failure of the online intervention in haemophilia despite success in rheumatoid arthritis.Trial registrationNL55883.041.16
Evaluating the Tubridge™ flow diverter for large cavernous carotid artery aneurysms
Authors: Jia Luqiong , Wang Jiejun , Zhang Longhui , Zhang Yunfeng , You Wei , Yang Xinjian , Lv Ming 
Published: December 2020

Abstract
Background
The Tubridge™ flow diverter (TFD) was recently developed in China; however, its safety and efficacy in treating large cavernous carotid artery aneurysms (LCCAs) are unclear. Our objective was to evaluate the safety and efficacy of the TFD in patients receiving TFDs to treat LCCAs (10–25 mm).

Methods
Between June 2013 and May 2014, seven patients with LCCAs were enrolled in our study, and all seven patients underwent TFD implantation combined with coils.

Results
Angiographic follow-up images were available for all seven patients at a median of 57.5 ± 16.7 (range, 6–69) months. Seven patients obtained favorable angiographic results defined as O’Kelly–Marotta Scale C and D. Clinical follow-up data were available for all seven patients at a median of 73.32 ± 3.6 (range, 66–78) months. No patients developed new neurological deficits. Six patients achieved a modified Rankin scale score of 0, and diplopia improved in the remaining patient.

Conclusions
The results were excellent for the aneurysms treated with TFDs in our patients with LCCAs. TFDs are feasible for the treatment of LCCAs, but a multicenter, controlled clinical trial is needed to evaluate the long-term safety and efficacy of the TFD to treat LCCAs.
Characteristics and reoperation rates of paediatric tarsal coalitions: A population-based study
Authors: Jackson Taylor J. , Mathew Smitha E. , Larson A. Noelle , Stans Anthony A. , Milbrandt Todd A. 
Published: December 2020

Purpose Tarsal coalitions are congenital fusions of two or more tarsal bones and can lead to foot pain and stiffness. Few studies examine the long-term reoperation rates following paediatric tarsal coalition surgery. Methods A population-based database, linking medical records at all medical centres to capture the entire medical history of the full population of a Midwest county, was used to identify tarsal coalitions in children between 1966 and 2018. Records were reviewed for clinical data, surgical records and followed up to identify any subsequent surgical interventions. Results A total of 58 patients (85 coalitions) were identified; 46 calcaneonavicular (CN) coalitions, 30 talocalcaneal (TC) coalitions and nine other coalitions (seven talonavicular, one naviculocuboid, one naviculocuneiform). In all, 46 coalitions were treated surgically (43 coalition resections, three arthrodeses) and 39 were treated nonoperatively. Patients treated surgically were less likely to report ongoing symptoms at final follow-up compared with patients managed nonoperatively (33% versus 67%; p = 0.0017). With a median 14.4 years (interquartile range 9.3 to 19.7) follow-up, there was an overall re-operation rate of 8.7% (4/46). Differences in reoperation rates by initial surgery (resection versus arthrodesis; p = 0.2936), coalition type (CN versus TC versus Other; p = 0.6487) or composition (osseous versus fibrocartilaginous; p = 0.29) did not reach statistical significance. Conclusion This is the first population-based study demonstrating the durability of surgical management of tarsal coalitions in a paediatric population. At final follow-up, patients treated surgically are less likely to report persistent symptoms compared with patients managed nonoperatively. Long-term reoperation rates appear to be low (8.7%). Level of evidence III
NEW COUNTING FORMULA FOR DOMINATING SETS IN PATH AND CYCLE GRAPHS
Authors: Casinillo Leomarich F 
Published: December 2020

Let G=(V(G), E(G)) be a path or cycle graph. A subset D of V(G) is a dominating set of G if for every u element of V(G)\D, there exists v element of D such that uv element of E(G), that is, N[D]=V(G). The domination number of G, denoted by gamma(G), is the smallest cardinality of a dominating set of G. A set D_1 subset of V(G) is a set containing dominating vertices of degree 2, that is, each vertex is internally stable. A set D_2 subset of V(G) is a set containing dominating vertices where one of the element say a element of D_2, and the rest are of degree 2. A set D_3 subset of V(G) is a set containing dominating vertices in which two of the elements say b, c element of D_3, deg(b)=deg(c)=1. This paper developed a new combinatorial formula that determines the number of ways of putting a dominating set in a path and cycle graphs of order n>=1 and n>=3, respectively. Further, a combinatorial function P^1_G(n), P^2_G(n) and P^3_G(n) that determines the probability of getting the set D_1, D_2, and D_3, respectively in graph G of order n were constructed.