bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does conjunctive tissue massage increase range of motion in muscles with plastic hypertonia due to Parkinson's disease?
Authors: Fiorelli Carolina Menezes , Camargo da Silva Amanda , Fiorelli Alexandre , Penedo Tiago , Araújo-Silva Fabiana , Barbieri Fabio Augusto 
Published: May 2020

BACKGROUND:Plastic hypertonia (rigidity), presented by individuals with Parkinson's disease (PD), leads to reduced range of motion (ROM), impairing daily activities and balance reactions. Connective tissue massage (CTM) promotes increased ROM in normotonic muscles, however its effects on hypertonic muscles are not yet known.
AIM: To verify the immediate and acute (1h after) effects of CTM on cervical ROM in individuals with PD.
METHOD: Cervical ROM during anterior flexion, extension, lateral flexion, and rotation was evaluated using a fleximeter at three moments: before (M1), immediately after (M2), and one hour after (M3) CTM in 14 older people with PD (PDG) and 13 neurologically healthy older people (CG).
RESULTS: The CG presented a higher ROM than the PDG for the cervical rotation movement. In addition, there was interaction between group*intervention time. The cervical rotation movement was higher for the CG than PDG at M2 and M3. On the other hand, there was no main effect of intervention time.
CONCLUSION: It was concluded that a single session of CTM was not sufficient to promote an increase in ROM in either normotonic or hypertonic muscles in older people, but the higher ROM for cervical rotation in the CG versus PDG was evident after CTM.
Gunung Kawi: Olahan Ketela Ungu Memberdayakan Masyarakat
Authors: Kumala Farida Nur , Hudha Muhammad Nur , Aji Sudi Dul 
Published: May 2020

Purple sweet potato Gunung Kawi is only sold raw, the price is very cheap. This causes the farmers to suffer losses. On the other hand, quite a lot of Wonosari Gunung Kawi residents become female migrant worker, because there are not enough producers in the village to meet the residents' needs. Based on that, the processing of purple sweet potato Gunung Kawi is needed to be developed into an effort that can absorb labor. The purpose of this service is to produce a purple sweet potato product business for residents of Wonosari Gunung Kawi. The service method used is through three stages, fisrt preparation for coordination and outreach activities to partners. The second stage the implementation phase of the training carried out training on the processing of purple sweet potato Gunung Kawi into several products such as sticks, bakpia and brownies from purple sweet potato of Gunung Kawi. The third stage is the evaluation and assistance. The instruments used in this service were interview sheets and activity observations. The results of the service show that the community has been able to produce and package products that are ready for sale and according to health standards.
Selama ini telo ungu gunung kawi hanya dijual secara mentah sehingga harga jual telo ungu sangat murah. Hal ini menyebabkan petani kebun telo mengalami kerugian khususnya pada musim tertentu. Dilain sisi, warga wonosari gunung kawi cukup banyak yang menjadi TKW karena penghasil di desa yang belum cukup untuk memenuhi kebutuhan warga. Berdasarkan hal tersebut diperlukan pengolahan SDA telo ungu yang dikembangkan menjadi suatu usaha yang dapat menyerap tenaga kerja. Tujuan pengabdian ini adalah menghasilkan usaha pengolahan telo ungu bagi warga Wonosari Gunung Kawi. Metode pengabdian yang digunakan adalah melalui tiga tahapan yakni persiapan dilakukan kegiatan koordinasi dan sosialisasi terhadap mitra, tahap kedua yakni tahap pelaksanaan pelatihan dilakukan pelatihan pengolaha telo ungu gunung kawi menjadi beberapa produk yakni stik, bakpia dan brownies telo ungu gunung kawi. Tahap ketiga adalah evaluasi daan pendampingan. Instrumen yang digunakan pada kegiatan pengabdian ini adalah lembar wawancara dan observasi kegiatan. Hasil pengabdian menunjukkan bahwa masyarakat telah mampu memproduksi dan mengemas stik, brownies dan bakpia menjadi produk yang siap untuk dijual dan sesuai standar kesehatan.
Blood Loss from Transverse Versus Longitudinal Uterine Incision in Abdominal Myomectomy: A Randomized Controlled Trial
Authors: Elguindy Alaa , Hemeda Hosam , Shawky Mohamed Esmat , Elsenity Mohamed , Elsayed Medhat Adel , Fahim Ahmed , Afifi Khaled , Nawara Maii 
Published: May 2020

Abstract
Background: It is unclear whether transverse uterine incision is non-inferior to longitudinal incision during myomectomy with regard to bleeding. Our aim was to compare between transverse and longitudinal uterine incisions in myomectomy. Methods: A parallel randomized controlled single-blinded study in a university affiliated hospital, in the period between January 2017 and April 2018, in which 52 women candidates for abdominal myomectomy were randomized into transverse uterine incision or longitudinal uterine incision groups (26 in each group). Intraoperative blood loss (estimated directly by blood volume in suction bottle and linen towels and indirectly by difference between preoperative and postoperative hematocrit), operative time and postoperative fever were analyzed. Results: No statistically significant difference was found between transverse and longitudinal incisions regarding intraoperative blood loss (389.7 ± 98.56 ml vs 485.04 ± 230.6 ml respectively, p value=0.07), operative time (59.96 ± 16.78 min vs 66.58 ± 17.33 min respectively, p value=0.18), and postoperative fever (4% vs 8.33%, p value=0.6). Conclusion: Transverse uterine incision does not cause more blood loss than longitudinal incision and is a reasonable option during abdominal myomectomy. Trial registration: NCT03009812 at clinicaltrials.gov, registered January 2017
Administration of Glycerol-Based Formulations in Sheep Results in Similar Ovulation Rate to eCG but Red Blood Cell Indices May Be Affected
Authors: Porcu Cristian , Sotgiu Francesca Daniela , Pasciu Valeria , Cappai Maria Grazia , Fernández Alicia Barbero- , Gonzalez-Bulnes Antonio , Dattena Maria , Gallus Marilia , Molle Giovanni , Berlinguer Fiametta 
Published: May 2020

Abstract
Background: The objective of this study was to investigate the metabolic and osmotic effects of different doses of glycerol or a glycerol – propylene glycol mixture in Sarda sheep with the aim to identify those able to beneficially modify ewe’s metabolic status without harmful changes in red blood cell (RBC) indices. Thereafter, the selected doses were tested for their effects on ewe’s ovarian activity during an induced follicular phase and compared to the effects of a hormonal treatment with equine chorionic gonadotrophin (eCG). Results: Glycerol was administered alone (G groups: 90% glycerol and 10% water; % v/v) or in combination with propylene glycol (M groups: 70% glycerol, 20% propylene glycol, 10% water; % v/v). Treatments were formulated to provide 100%, 75%, 50% and 25% of the amount of energy supplied in previous experiments. Obtained results showed that the formulations G75 and M75 (22.5% and 18.2% on DM basis, respectively) induce metabolic changes comparable to those induced by M100. The latter dose has been already evaluated for its effects on sheep metabolism and reproductive performance. However, with these high doses, plasma osmolality increased significantly, and RBC indices showed significant alterations. The low dose groups (G25 and M25, 8.6% and 6.9% on DM basis, respectively) did not show any alterations in plasma osmolality and RBC indices, but the metabolic milieu differed markedly from that of M100. Between the medium dose groups, M50 (12.9% on DM basis) showed a more comparable milieu to M100 than G50 (15.9% on DM basis) and no RBC alterations. Therefore, M75, G75 and M50 doses were tested for their effect on ovarian functions and proved to be equally effective as eCG. Conclusion: The results of the present study evidenced an alteration of RBC indices, and possibly of their functions, as a side effect of glycerol administration at high doses in the diet of ewes. Therefore, protocols foreseeing the administration of glycerol should be tested for their effects on RBC indices and functions. In general terms, the medium dose of the glucogenic mixture (12.9% of dietary DM on offer) should be preferred.
Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth
Authors: Qin Le , Zhao Ruocong , Chen Dongmei , Wei Xinru , Wu Qiting , Long Youguo , Jiang Zhiwu , Li Yangqiu , Wu Haipeng , Zhang Xuchao , Wu Yilong , Cui Shuzhong , Wei Wei , Yao Huihui , Liu Zixia , Cao Su , Yao Yao , Zhang Zhenfeng , Li Peng 
Published: May 2020

Abstract
Background: Chimeric antigen receptor T cells (CAR-T cells) therapy has been well recognized for treating B cell-derived malignancy. However, the efficacy of CAR-T cells against solid tumors remains dissatisfactory, partially due to the heterogeneity of solid tumors and T cell exhaustion in tumor microenvironment. PD-L1 is up-regulated in multiple solid tumors, resulting in T cell exhaustion upon binding to its receptor PD-1. Methods: Here, we designed a dominant-negative form of PD-1 , dPD1z, a vector containing the extracellular and transmembrane regions of human PD-1, and a CAR vector against PD-L1, CARPD-L1z, a vector employs a high-affinity single-chain variable fragment (scFv) against human PD-L1. These two vectors shared the same intracellular structure, including 4-1BB and TLR2 co-stimulatory domains, and the CD3ζ signaling domain. Results: dPD1z T and CARPD-L1z T cells efficiently lysed PD-L1 + tumor cells and had enhanced cytokine secretion in vitro and suppressed the growth of non-small cell lung cancer (NSCLC), gastric cancer and hepatoma carcinoma in patient-derived xenograft (PDX). However, the combination of anti-mesothelin CAR-T cells (CARMSLNz T) with dPD1z T or CARPD-L1z T cells did not repress tumor growth synergistically in PDX, as CARMSLNz T cells upregulated PD-L1 expression upon activation and were subsequently attacked by dPD1z T or CARPD-L1z T cells. Conclusions: In conclusion, we demonstrate CAR-T cells targeting PD-L1 were effective for suppressing the growth of multiple types of solid tumors in PDX models though their safety needs to be carefully examined.
Youtube as a Source of Patients’ and Specialists’ Information on Hemorrhoids and Hemorrhoid Surgery
Authors: Sturiale Alessandro , Dowais Raad , Porzio Felipe Celedon , Brusciano Luigi , Gallo Gaetano , Morganti Riccardo , Naldini Gabriele 
Published: May 2020

Background:In the past, most people sought medical information by consulting health care professionals. Nowadays, many people started to use online resources to access medical information.Objective:The study aims to investigate whether YouTube videos on hemorrhoids and hemorrhoid surgery can be a useful e-learning source for the general population, surgical trainees and specialists.Methods:A YouTube search was performed in October 2019 using the keywords “hemorrhoids” and “hemorrhoid surgery”, and the videos were divided into 2 groups according to the keywords. Three independent researchers assessed the metadata and classified them according to the level of accuracy (hemorrhoid group) and the level of usefulness (hemorrhoid surgery group). Cohen’s test and Kappa (K) value were used to evaluate the inter-investigators agreement.Results:A total of 200 videos were analyzed, 100 for each keyword. Regarding the hemorrhoid group, 43 videos (48.3%) were misleading, 9 were accurate (10.1%), 18 were approximate (20.2%), and 19 were considered a personal experience (21.4%). Regarding the hemorrhoid surgery group, around 60% of the videos were lacking a clear explanation, while about 16% were inaccurate. Only the remaining 24% were considered useful for teaching.Conclusion:Around half of the YouTube videos regarding hemorrhoids topic were found to be misleading or inaccurate and present a risk of harmful consequences. Credible videos with accurate information need to be uploaded by medical professionals and medical institutions and some sort of filtering, using categories by the staff of YouTube, appears to be necessary. Care must be taken to produce clear, high-quality operative clips with proper scientific commentary.
Radioprotective Effect of Pioglitazone Against Genotoxicity Induced by Ionizing Radiation in Healthy Human Lymphocytes
Authors: Kazemi Roya , Hosseinimehr Seyed J. 
Published: May 2020

Objective:
Pioglitazone (PG) is used to control high blood sugar in patients with type 2 diabetes
mellitus. PG acts as a peroxisome proliferator-activated receptor γ agonist. In addition to the
insulin-sensitizing effect, PG possesses anti-inflammatory effect. In this study, the protective effect of
PG was evaluated against DNA damage induced by ionizing radiation in healthy human lymphocytes.

Methods:
The microtubes containing human whole blood were treated with PG at various
concentrations (1-50 μM) for three hours. Then, the blood samples were irradiated with X-ray.
Lymphocytes were cultured for determining the frequency of micronuclei as a genotoxicity
biomarker in binucleated lymphocytes.

Results:
The mean percentage of micronuclei was significantly increased in human lymphocytes
when were exposed to IR, while it was decreased in lymphocytes pre-treated with PG. The
maximum reduction in the frequency of micronuclei in irradiated lymphocytes was observed at 5
μM of PG treatment (48% decrease).

Conclusion:
The anti-inflammatory property is suggested the mechanism action of PG for
protection human lymphocytes against genotoxicity induced by ionizing radiation.
A Systematic Literature Review of Curcumin with Promising Antileishmanial Activity
Authors: Saberi Reza , Fakhar Mahdi , Asfaram Shabnam , Akhtari Javad , Nakhaei Maryam , Keighobadi Masoud 
Published: May 2020

Background:
Curcumin (CUR) is a bright yellow chemical and it is used as an additive
in foods. Recently CUR and its associated bioactive compounds have received much attention in
the literature review. The aim of this systematic review is to overview the antileishmanial properties
of CUR and its mechanism; perhaps the results of this study will be used for therapeutic and
preventive purposes.

Methods:
Following the PRISMA guidelines, international databases were systematically
searched for studies published until September 2019. Articles related to the subject were selected
and included in this systematic review.

Results:
A total of 15 articles met our eligibility criteria. Then, the effect of CUR and its
associated bioactive compounds on Leishmania species was evaluated. In most studies
CUR/derivatives were tested on L. major and in vitro condition. Most investigations were
conducted on the promastigote rather than the more relevant intracellular amastigote stage. Our
results showed that CUR overcomes the inhibitory effect of nitric oxide (NO) on Leishmania
parasites.

Conclusions:
This review indicated that CUR derivatives instead of alone CUR showed a high
potential to serve as an effective herbal drug against leishmaniasis. Moreover, we concluded that
the antileishmanial activity of CUR/bioactive compounds is mostly due to increasing oxidative
stress and inducing apoptosis.
Product Quality Tracing in Manufacturing Supply Chain Based on Big Data Technology
Authors: Huang Yin , Huang Shumin , Zhang Yichen , Yang Xue , Liu Runda 
Published: May 2020

Background:
Big data technology has been widely used in manufacturing supply chain management.
However, traditional big data technology has some limitations, and it cannot achieve the continuous
improvement of whole-process product quality tracing.

Objective :
The purpose of this study is to overcome the limitations by patents analysis and provide new
big data technology and technical modes to make the continuous improvements of whole-process product
quality tracing for achieving effective product lifecycle management based on big data technology.

Methods:
The research method, patent analysis, and comparative analysis are employed in this study to
analyze product quality tracing in the manufacturing supply chain based on big data technology.
Moreover, the procedure and steps of the new big data technology - Product Digital Twin (PDT), and
its technical modes are designed by process design methods. Its key technologies are also analyzed and
compared with traditional big data technology by the comparative study.

Results:
The research achieves the continuous improvements of whole-process product quality tracing
based on new big data technology - PDT by patent analysis. The formation process and behavior of
manufactured products in the realistic environment are simulated, monitored, diagnosed, predicted, and
controlled. In this way, the high-efficient coordination in various stages of the product lifecycle is propelled
fundamentally and the continuous improvements of the whole-process product quality tracing
based on big data technology is analyzed.

Conclusion:
Three new technical modes based on big data technology are predicted for future researches
and patents, namely, the immersive development mode integrating big data and the virtual
reality technology, the knowledge-based multivariant coordinated development mode, and the lifecycle
extended development model based on multi-domain interoperability.
Dithranol: An Insight into its Novel Delivery Cargos for Psoriasis Management
Authors: Kadian Varsha , Kumar Sunil , Saini Komal , Kakkar Vandita , Rao Rekha 
Published: May 2020

Objective:
Dithranol (DTH) is a well-known moiety that has long been used promisingly
to impede and treat skin disorders, particularly psoriasis. Nowadays, a rekindled interest in the use
of DTH for this disorder has been observed. Side effects associated with conventional topical formulations
of this moiety have aroused the interest of the scientific community in investigating novel
cargos of DTH for psoriasis management.

Results:
Previous research has evidenced the anti-inflammatory and anti-proliferating potential of
DTH. Numerous studies have indicated that DTH inhibits polymorphonuclear (PMN) leucocyte,
modulates epidermal cell receptors and promotes anti-psoriatic action. However, some deterrent factors
like poor solubility, stability, toxicity, staining and skin irritation hamper its use as a potential
therapeutic agent. With the adoption of novel drug delivery technologies, the above mentioned inherent
limitations of DTH have been compensated to reestablish this drug moiety.

Conclusion:
This article reviews novel drug delivery aspects, safety concerns, clinical evidence,
current status, and future opportunities of DTH in the management of psoriasis. Further, it will update
researchers on this promising drug moiety, which is free from systemic adverse responses in
comparison to other therapeutic molecules like steroids, for psoriasis treatment.
Using Reports of Symptoms and Diagnoses on Social Media to Predict COVID-19 Case Counts in Mainland China: Observational Infoveillance Study
Authors: Shen Cuihua , Chen Anfan , Luo Chen , Zhang Jingwen , Feng Bo , Liao Wang 
Published: May 2020

Background
Coronavirus disease (COVID-19) has affected more than 200 countries and territories worldwide. This disease poses an extraordinary challenge for public health systems because screening and surveillance capacity is often severely limited, especially during the beginning of the outbreak; this can fuel the outbreak, as many patients can unknowingly infect other people.

Objective
The aim of this study was to collect and analyze posts related to COVID-19 on Weibo, a popular Twitter-like social media site in China. To our knowledge, this infoveillance study employs the largest, most comprehensive, and most fine-grained social media data to date to predict COVID-19 case counts in mainland China.

Methods
We built a Weibo user pool of 250 million people, approximately half the entire monthly active Weibo user population. Using a comprehensive list of 167 keywords, we retrieved and analyzed around 15 million COVID-19–related posts from our user pool from November 1, 2019 to March 31, 2020. We developed a machine learning classifier to identify “sick posts,” in which users report their own or other people’s symptoms and diagnoses related to COVID-19. Using officially reported case counts as the outcome, we then estimated the Granger causality of sick posts and other COVID-19 posts on daily case counts. For a subset of geotagged posts (3.10% of all retrieved posts), we also ran separate predictive models for Hubei province, the epicenter of the initial outbreak, and the rest of mainland China.

Results
We found that reports of symptoms and diagnosis of COVID-19 significantly predicted daily case counts up to 14 days ahead of official statistics, whereas other COVID-19 posts did not have similar predictive power. For the subset of geotagged posts, we found that the predictive pattern held true for both Hubei province and the rest of mainland China regardless of the unequal distribution of health care resources and the outbreak timeline.

Conclusions
Public social media data can be usefully harnessed to predict infection cases and inform timely responses. Researchers and disease control agencies should pay close attention to the social media infosphere regarding COVID-19. In addition to monitoring overall search and posting activities, leveraging machine learning approaches and theoretical understanding of information sharing behaviors is a promising approach to identify true disease signals and improve the effectiveness of infoveillance.
STUDY OF MOTIVATION TYPES OF ENGLISH-MAJORING STUDENTS AND DEMOTIVATING FACTORS - IN THE CONTEXT OF NATIONAL UNIVERSITY OF MONGOLIA, ERDENET SCHOOL
Authors: Shagdarsuren Solongo , Batchuluun Ulambayar , Lang Daniel Lindbergh 
Published: May 2020

A decline in number of credit hours of English courses for English-majoring students at National University of Mongolia is forcing teachers and students to focus on how to learn English more effectively and what factors would affect that process within credit hours allowed at the university. However, the English teaching class hours in Mongolian secondary schools have been increasing for the last few years, due to the interest in learning English as a foreign language, and resulting in a growth in the demand for English teachers. This study has a goal to investigate into motivation of English-majoring students towards learning English and the factors affecting them to be demotivated. Twenty students studying English as a major at National University of Mongolia, Erdenet School completed the research questionnaire which intended to discover English learning motivation through 12 items and attended focus group interview with 5 questions to find internal and external demotivating factors in 2019-2020 academic year. The students had instrumental orientation and demonstrated a strong desire to learn English. Furthermore, they were demotivated by their teachers’ and classmates’ attitudes and living conditions. The researchers suggested some recommendations based on the study findings.
Interferon: Role in health, current trends and therapeutic potentials
Authors: Uchendu Ikenna Kingsley , Ojiako Nkiruka Peace 
Published: May 2020

This mini review presents the current trends and topical issues on interferon. This article illustrates the theoretical background and details about interferon, its mechanism of action or roles in the prevention of microbial- or pathogenic disease progression, types and classes, and their therapeutic potentials. All the reported applications have shown that interferon has found its application in gene manipulation and expression of gene products; immunological techniques, viral disease treatment and in the treatment of cancers.
Keywords: Interferon, cancers, cancer therapy, viral infection, viral disease treatment.