bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in substance use and primary prevention variables among adolescents in Lithuania, 2006–19
Authors: Asgeirsdottir Bryndis Bjork , Kristjansson Alfgeir Logi , Sigfusson Jon , Allegrante John P , Sigfusdottir Inga Dora 
Published: May 2020

Abstract

Background
Since the implementation of the Icelandic Model for Primary Prevention of Substance Use in Iceland (IPM), substance use has decreased steadily among 14–16-year-old adolescents and primary prevention factors have improved. Although the IPM is being implemented in several other regions around the world, information documenting its effectiveness in other country contexts is lacking. This study assessed trends in substance use and primary prevention variables in three cities in Lithuania following the implementation of the IPM.

Methods
Data collected from repeated, comparative cross-sectional self-report surveys conducted among a total of 30 572 10th graders in the cities of Kaunas, Klaipeda and Vilnius, Lithuania, from 2006 to 2019, were analyzed. Cochran–Armitage test for linear trend and analysis of variance for linear trend was used to assess time-trends in prevalence of substance use and mean levels of primary prevention variables over time.

Results
Following the implementation of IPM rates of cigarette smoking and the use of alcohol, cannabis and amphetamine has decreased among 10th graders in Lithuania’s three largest cities and simultaneously preventive variables targeted have improved. Similar to Iceland, primary prevention variables were related to substance use in the expected direction, with the exception of organized sports participation, which was not associated with less likelihood of alcohol, cannabis and amphetamine use.

Conclusion
Trends in substance use and primary prevention variables following the implementation of the IPM are similar in the three cities in Lithuania as in Iceland. Further research is needed to better understand the mechanisms underlying these trends.
Global warming shifts the composition of the abundant bacterial phyllosphere microbiota as indicated by a cultivation-dependent and -independent study of the grassland phyllosphere of a long-term warming field experiment
Authors: Aydogan Ebru L , Budich Olga , Hardt Martin , Choi Young Hae , Jansen-Willems Anne B , Moser Gerald , Müller Christoph , Kämpfer Peter , Glaeser Stefanie P 
Published: May 2020

ABSTRACT
The leaf-colonizing bacterial microbiota was studied in a long-term warming experiment on a permanent grassland, which had been continuously exposed to increased surface temperature (+2°C) for more than six years. Two abundant plant species, Arrhenatherum elatius and Galium album, were studied. Surface warming reduced stomata opening and changed leaf metabolite profiles. Leaf surface colonization and the concentration of leaf-associated bacterial cells were not affected. However, bacterial 16S ribosomal RNA (rRNA) gene amplicon Illumina sequencing showed significant temperature effects on the plant species-specific phyllosphere microbiota. Warming partially affected the concentrations of cultured bacteria and had a significant effect on the composition of most abundant cultured plant species-specific bacteria. The abundance of Sphingomonas was significantly reduced. Sphingomonas isolates from warmed plots represented different phylotypes, had different physiological traits and were better adapted to higher temperatures. Among Methylobacterium isolates, a novel phylotype with a specific mxaFtype was cultured from plants of warmed plots while the most abundant phylotype cultured from control plots was strongly reduced. This study clearly showed a correlation of long-term surface warming with changes in the plant physiology and the development of a physiologically and genetically adapted phyllosphere microbiota.
Residual lattice strain in quartzites as a potential palaeo-piezometer
Authors: Wenk Hans-Rudolf , Chandler Brian Chase , Chen Kai , Li Yao , Tamura Nobumichi , Yu Rong 
Published: May 2020

SUMMARY
If a crystal lattice is subjected to a stress, it becomes distorted and no longer represents the ideal crystal symmetry, and if the stress introduces defects such as dislocations, some of this distortion is preserved after the applied stress is removed. In this study, we investigate lattice distortion in quartz at the micron scale with synchrotron X-ray Laue diffraction. From Laue images the local deviatoric strain tensor is derived and corresponding stresses are calculated based on elastic properties. The method is applied to metasedimentary quartzites from the Bergell Alps that were deformed at conditions of greenschist facies metamorphism. The residual palaeostrain is represented in maps of the deviatoric strain tensor components and with deviatoric strain axis pole figures. Data suggest overall shortening perpendicular to the schistosity plane but with considerable asymmetry relative to foliation and lineation, probably attributed to simple shear. Crystallographic pole figures from Laue diffraction agree with neutron diffraction and EBSD measurements and display quartz c-axes girdle distributions with maxima also perpendicular to schistosity. The method shows promise to be used as a palaeo-piezometer to unravel the stress field during tectonic deformation.
Rapid implementation of a COVID-19 remote patient monitoring program
Authors: Annis Tucker , Pleasants Susan , Hultman Gretchen , Lindemann Elizabeth , Thompson Joshua A , Billecke Stephanie , Badlani Sameer , Melton Genevieve B 
Published: May 2020

Abstract

Objective
The study sought to evaluate early lessons from a remote patient monitoring engagement and education technology solution for patients with coronavirus disease 2019 (COVID-19) symptoms.

Materials and Methods
A COVID-19–specific remote patient monitoring solution (GetWell Loop) was offered to patients with COVID-19 symptoms. The program engaged patients and provided educational materials and the opportunity to share concerns. Alerts were resolved through a virtual care workforce of providers and medical students.

Results
Between March 18 and April 20, 2020, 2255 of 3701 (60.93%) patients with COVID-19 symptoms enrolled, resulting in over 2303 alerts, 4613 messages, 13 hospital admissions, and 91 emergency room visits. A satisfaction survey was given to 300 patient respondents, 74% of whom would be extremely likely to recommend their doctor.

Discussion
This program provided a safe and satisfying experience for patients while minimizing COVID-19 exposure and in-person healthcare utilization.

Conclusions
Remote patient monitoring appears to be an effective approach for managing COVID-19 symptoms at home.
The tradeoffs between safety and alert fatigue: Data from a national evaluation of hospital medication-related clinical decision support
Authors: Co Zoe , Holmgren A Jay , Classen David C , Newmark Lisa , Seger Diane L , Danforth Melissa , Bates David W 
Published: May 2020

Abstract

Objective
The study sought to evaluate the overall performance of hospitals that used the Computerized Physician Order Entry Evaluation Tool in both 2017 and 2018, along with their performance against fatal orders and nuisance orders.

Materials and Methods
We evaluated 1599 hospitals that took the test in both 2017 and 2018 by using their overall percentage scores on the test, along with the percentage of fatal orders appropriately alerted on, and the percentage of nuisance orders incorrectly alerted on.

Results
Hospitals showed overall improvement; the mean score in 2017 was 58.1%, and this increased to 66.2% in 2018. Fatal order performance improved slightly from 78.8% to 83.0% (P &lt; .001), though there was almost no change in nuisance order performance (89.0% to 89.7%; P = .43). Hospitals alerting on one or more nuisance orders had a 3-percentage-point increase in their overall score.

Discussion
Despite the improvement of overall scores in 2017 and 2018, there was little improvement in fatal order performance, suggesting that hospitals are not targeting the deadliest orders first. Nuisance order performance showed almost no improvement, and some hospitals may be achieving higher scores by overalerting, suggesting that the thresholds for which alerts are fired from are too low.

Conclusions
Although hospitals improved overall from 2017 to 2018, there is still important room for improvement for both fatal and nuisance orders. Hospitals that incorrectly alerted on one or more nuisance orders had slightly higher overall performance, suggesting that some hospitals may be achieving higher scores at the cost of overalerting, which has the potential to cause clinician burnout and even worsen safety.
Effect of the Timing of Antiretroviral Treatment Initiation on Outcomes in Children Living With Human Immunodeficiency Virus Admitted With Severe Acute Malnutrition
Authors: Archary Moherndran , Sartorius Benn , La Russa Philip , Sibaya Thobekile , Healy Micheal , Bobat Raziya A 
Published: May 2020

Abstract

Background
Delays in early infant diagnosis and antiretroviral treatment (ART) initiation in developing countries frequently result in malnutrition at initial presentation with associated higher mortality and delayed immune recovery. The optimal timing of ART initiation is yet to be established.

Methods
Eighty-two children admitted with HIV and severe acute malnutrition (SAM) between July 2012 and December 2015 were enrolled. Patients were randomized to initiate ART within 14 days from admission (early arm) or delay ART initiation until nutritional recovery and &gt;14 days after admission (delayed arm). All patients received a standardized treatment and feeding protocol and were followed to 48 weeks.

Results
The mean age of the patients at baseline was 23.3 months (standard deviation [SD], 27.9; range, 1.6–129 months). The mean time from admission to ART initiation was 5.6 days (SD, 4.4) in the early arm and 23 days (SD, 5.8) in the delayed arm (P &lt; .001). There was no significant difference in mortality (P = .62), virologic response (P = .53), and anthropometric response (P = .57) between the 2 groups at 48 weeks. However, the rates of change in CD4, viral load, weight for age z score, and height for age z score occurred earlier and favored the delayed arm at early time points but were not significant at 24 and 48 months.

Conclusions
Despite initial improved responses in the delayed arm, lack of difference in outcome at 48 weeks supports a pragmatic approach with earlier ART initiation in children living with HIV admitted with SAM.
In this randomised controlled study of ART initiation in children admitted with HIV and severe acute malnutrition (SAM), despite initial improved responses in the delayed arm, lack of difference in outcome at 48 weeks supports a pragmatic approach with earlier ART initiation in children living with HIV admitted with SAM.

Clinical Trials Registration
PACTR 21609001751384.
In vitropharmacokinetics/pharmacodynamics modeling and efficacy against systemic candidiasis inDrosophila melanogasterof a bisaryloxypropanamine derivative
Authors: Dalla Lana Daiane Flores , Kaminski Taís Fernanda Andrzejewski , Lavorato Stefânia Neiva , Merkel Simone , Zanette Régis Adriel , da Rosa Priscila Dallé , Staudt Keli Jaqueline , de Araújo Bibiana Verlindo , da Costa Bárbara , Quatrin Priscilla Maciel , Bazana Luana Candice Genz , Ferreira Felipe Alves , Caurio Cássia Ferreira Braz , de Andrade Saulo Fernandes , Alves Ricardo José , Fuentefria Alexandre Meneghello 
Published: May 2020

AbstractThe number of deaths due to systemic fungal infections is increasing alarmingly, which is aggravated by the limitations of traditional treatments and multidrug resistance. Therefore, the research and development of new therapeutic options against pathogenic fungi is an urgent need. To evaluate the fungicidal activity of a synthetic compound, 1,3-bis-(3,4-dichlorophenoxy)propan-2-aminium chloride (2j), through time-kill studies and pharmacokinetics/pharmacodynamics (PK/PD) modeling. The protective effect of the compound was also evaluated using the Drosophila melanogaster minihost model of candidiasis. Mathematical modeling of time-kill data of compound 2j was performed to obtain PD characteristics. Additionally, Toll-deficient D. melanogaster flies were infected with a Candida albicans strain and treated with 2j. We observed that compound 2j demonstrated a time- and dose-dependent fungicidal effect against Candida spp. and dermatophytes, even at low concentrations, and rapidly achieved kill rates reaching the maximum effect in less than one hour. The efficacy of the compound against systemic candidiasis in D. melanogaster flies was comparable to that achieved by fluconazole. These results support the potential of compound 2j as a systemic antifungal agent candidate and serve as a starting point for further studies involving mammalian animal models.
Powering central compact objects with a tangled crustal magnetic field
Authors: Gourgouliatos Konstantinos N , Hollerbach Rainer , Igoshev Andrei P 
Published: May 2020

ABSTRACT
Central Compact Objects (CCOs) are X-ray sources with luminosity ranging between 1032 and 1034 erg s−1, located at the centres of supernova remnants. Some of them have been confirmed to be neutron stars. Timing observations have allowed the estimation of their dipole magnetic field, placing them in the range ∼1010–1011 G. The decay of their weak dipole fields, mediated by the Hall effect and Ohmic dissipation, cannot provide sufficient thermal energy to power their X-ray luminosity, as opposed to magnetars whose X-ray luminosities are comparable. Motivated by the question of producing high X-ray power through magnetic field decay while maintaining a weak dipole field, we explore the evolution of a crustal magnetic field that does not consist of an ordered axisymmetric structure, but rather comprises a tangled configuration. This can be the outcome of a non-self-excited dynamo, buried inside the crust by fallback material following the supernova explosion. We find that such initial conditions lead to the emergence of the magnetic field from the surface of the star and the formation of a dipolar magnetic field component. An internal tangled magnetic field of the order of 1014 G can provide sufficient Ohmic heating to the crust and power CCOs, while the dipole field it forms is approximately 1010 G, as observed in CCOs.
SDSS-IV MaNGA: Excavating the fossil record of stellar populations in spiral galaxies
Authors: Peterken Thomas , Merrifield Michael , Aragón-Salamanca Alfonso , Fraser-McKelvie Amelia , Avila-Reese Vladimir , Riffel Rogério , Knapen Johan , Drory Niv 
Published: May 2020

ABSTRACT
We perform a ‘fossil record’ analysis for ≈800 low-redshift spiral galaxies, using starlight applied to integral field spectroscopic observations from the SDSS-IV MaNGA survey to obtain fully spatially resolved high-resolution star formation histories (SFHs). From the SFHs, we are able to build maps indicating the present-day distribution of stellar populations of different ages in each galaxy. We find small negative mean age gradients in most spiral galaxies, especially at high stellar mass, which reflects the formation times of stellar populations at different galactocentric radii. We show that the youngest (&lt;108.5 yr) populations exhibit significantly more extended distributions than the oldest (&gt;109.5 yr), again with a strong dependence on stellar mass. By interpreting the radial profiles of ‘time slices’ as indicative of the size of the galaxy at the time those populations had formed, we are able to trace the simultaneous growth in mass and size of the spiral galaxies over the last 10 Gyr. Despite finding that the evolution of the measured light-weighted radius is consistent with inside-out growth in the majority of spiral galaxies, the evolution of an equivalent mass-weighted radius has changed little over the same time period. Since radial migration effects are likely to be small, we conclude that the growth of discs in spiral galaxies has occurred predominantly through an inside-out mode (with the effect greatest in high-mass galaxies), but this has not had anywhere near as much impact on the distribution of mass within spiral galaxies.
A roadmap to hadronic supercriticalities: a comprehensive study of the parameter space for high-energy astrophysical sources
Authors: Mastichiadis Apostolos , Florou Ioulia , Kefala Elina , Boula Stella S , Petropoulou Maria 
Published: May 2020

ABSTRACT
Hadronic supercriticalities are radiative instabilities that appear when large amounts of energy are stored in relativistic protons. When the proton energy density exceeds some critical value, a runaway process is initiated resulting in the explosive transfer of the proton energy into electron–positron pairs and radiation. The runaway also leads to an increase of the radiative efficiency, namely the ratio of the photon luminosity to the injected proton luminosity. We perform a comprehensive study of the parameter space by investigating the onset of hadronic supercriticalities for a wide range of source parameters (i.e. magnetic field strengths of 1 G−100 kG and radii of 1011−1016 cm) and maximum proton Lorentz factors (103−109). We show that supercriticalities are possible for the whole range of source parameters related to compact astrophysical sources, like gamma-ray bursts and cores and jets of active galactic nuclei. We also provide an in-depth look at the physical mechanisms of hadronic supercriticalities and show that magnetized relativistic plasmas are excellent examples of non-linear dynamical systems in high-energy astrophysics.
Onthe changes in the physical properties of the ionized region around the Weigelt structures in η Carinae over the 5.54-yr spectroscopic cycle
Authors: Teodoro M , Gull T R , Bautista M A , Hillier D J , Weigelt G , Corcoran M F 
Published: May 2020

ABSTRACT
We present HST/STIS observations and analysis of two prominent nebular structures around the central source of η Carinae, the knots C and D. The former is brighter than the latter for emission lines from intermediate- or high-ionization potential ions. The brightness of lines from intermediate- and high-ionization potential ions significantly decreases at phases around periastron. We do not see conspicuous changes in the brightness of lines from low-ionization potential (&lt;13.6 eV) ions over the orbital period. Line ratios suggest that the total extinction towards the Weigelt structures is AV = 2.0. Weigelt C and D are characterized by an electron density of 106.9 cm−3 that does not significantly change throughout the orbital cycle. The electron temperature varies from 5500 (around periastron) to 7200 K (around apastron). The relative changes in the brightness of the He i lines are well reproduced by the variations in the electron temperature alone. We found that, at phases around periastron, the electron temperature seems to be higher for Weigelt C than that of D. The Weigelt structures are located close to the Homunculus equatorial plane, at a distance of about 1240 au from the central source. From the analysis of proper motion and age, the Weigelt complex can be associated with the equatorial structure called ‘Butterfly Nebula’ surrounding the central binary system.
On the origin of GW190425
Authors: Romero-Shaw Isobel M , Farrow Nicholas , Stevenson Simon , Thrane Eric , Zhu Xing-Jiang 
Published: May 2020

ABSTRACT
The LIGO/Virgo collaborations recently announced the detection of a binary neutron star merger, GW190425. The mass of GW190425 is significantly larger than the masses of Galactic double neutron stars known through radio astronomy. We hypothesize that GW190425 formed differently from Galactic double neutron stars, via unstable ‘case BB’ mass transfer. According to this hypothesis, the progenitor of GW190425 was a binary consisting of a neutron star and a ∼4–$5\, {\mathrm{ M}_\odot }$ helium star, which underwent common-envelope evolution. Following the supernova of the helium star, an eccentric double neutron star was formed, which merged in ${\lesssim }10\, {\rm Myr}$. The helium star progenitor may explain the unusually large mass of GW190425, while the short time to merger may explain why similar systems are not observed in radio. To test this hypothesis, we measure the eccentricity of GW190425 using publicly available LIGO/Virgo data. We constrain the eccentricity at $10\, {\rm Hz}$ to be e ≤ 0.007 with $90{{\ \rm per\ cent}}$ confidence. This provides no evidence for or against the unstable mass transfer scenario, because the binary is likely to have circularized to e ≲ 10−4 by the time it was detected. Future detectors will help to reveal the formation channel of mergers similar to GW190425 using eccentricity measurements.
Exosomes and soluble secretome from hormone-treated endometrial epithelial cells direct embryo implantation
Authors: Gurung S , Greening D W , Catt S , Salamonsen L , Evans J 
Published: May 2020

Abstract
A successful pregnancy requires a synchronous dialogue between endometrium and embryo within the endometrial milieu. The aim of this study was to assess the role in the implantation of mediators in the endometrial milieu. Total secretome (TS), soluble secretome (SS) and small extracellular vesicles (containing exosomes) were generated from hormonally primed human endometrial epithelial cell culture medium. Human trophectoderm stem cell-derived spheroids were cultured with TS, SS or exosomes (30 µg/ml) on hormonally primed epithelial cells, with exosomes significantly increasing cell adhesion and outgrowth. Furthermore, F1 mouse 2-cell embryos were cultured in groups for 48 h followed by culture with each secretome fraction (30 µg/ml) for 48 h. Blastocyst cell number and hatching were quantified. In addition, blastocysts were further cultured on a fibronectin matrix for 72 h or transferred to recipient mice (with corresponding secretomes) with embryo implantation assessed after 6 days. Exosomes significantly increased total cell number in mouse embryos and complete hatching from zona pellucida, with both exosomes and SS significantly enhancing mouse embryo outgrowth. Importantly, exosomes increased the embryo implantation rate in comparison to other secretome fractions (normalized based on treatment amount) from the endometrial epithelia. These data indicate that endometrial epithelial exosomes support embryo growth, development and implantation while the SS has selective involvement specifically on mouse embryo outgrowth. This finding provides new insights into the molecular differences of endometrial secretome components in implantation and early embryo development and may implicate endometrial exosomes in the pathophysiology of implantation failure in infertility.