bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sociodemographic Characteristics as Predictors of Outcomes in Hepatocellular Carcinoma: A Retrospective Cohort Study
Authors: Beutler Bryce D. , Ulanja Mark B. , Krishan Rohee , Aluru Vijay , Ndukwu Munachismo L. , Hagen Molly M. , Dupin Zachary D. , Willyard Charles E. , Moody Alastair E. , Boampong-Konam Killian , Zell Steven C. 
Published: September 2020

Background: Race, gender, insurance status, and income play important roles in predicting health care outcomes. However, the impact of these factors has yet to be fully elucidated in the setting of hepatocellular carcinoma (HCC). Methods: We designed a retrospective cohort study utilizing data from the Surveillance, Epidemiology, and End Results (SEER) program to identify patients diagnosed with resectable HCC (N = 28,518). Demographic factors of interest included race (Asian/Pacific Islander [API], African American [AA], Native American/Alaska Native [NA], or White [WH]) and gender (male [M] or female [F]). Insurance classifications included those having Medicare/Private Insurance [ME/PI], Medicaid [MAID], or No Insurance [NI]. Median household income was estimated for all diagnosed with HCC. Endpoints included: (1) overall survival; (2) likelihood of receiving a recommendation for surgery; and (3) specific surgical intervention performed. Multivariate multinomial logistic regression for relative risk ratio (RRR) and Cox regression models were used to identify pertinent associations. Results: Race, gender, insurance status, and income had statistically significant effects on the likelihood of surgical recommendation and overall survival. API were more likely to receive a recommendation for hepatic resection (RRR = 1.45; 95% CI: 1.31-1.61; Reference Race: AA) and exhibited prolonged overall survival (HR = 0.77; 95% CI: 0.73-0.82; Reference Race: AA) as compared to members of any other ethnic group; there was no difference in these endpoints between AA, NA, or WH individuals. Gender also had a significant effect on survival: Females exhibited superior overall survival (HR = 0.89; 95% CI: 0.85-0.93; Reference Gender: M) as compared to males. Patients who had ME/PI were more likely than those with MAID or NI to receive a surgical recommendation. ME/PI was also associated with superior overall survival. Conclusions: Race, gender, insurance status, and income have measurable effects on HCC management and outcomes. The underlying causes of these disparities warrant further investigation.
Atezolizumab-induced hemolytic anemia – A case report
Authors: Younce Christina M , Lawton Jessica M , Patel Dhimant R 
Published: September 2020

Introduction Atezolizumab is currently the only immunotherapy used in conjunction with nab-paclitaxel for locally advanced or triple negative breast cancer. Limited data is available regarding hemolytic anemia as a side effect of atezolizumab. Case report We describe a 59-year-old female with a history of triple negative breast cancer with bone metastases presenting for follow up on Cycle 1, Day 15 of atezolizumab and nab-paclitaxel (100 mg/m2). Patient’s complete blood count (CBC) showed macrocytic anemia, with further workup significant for autoimmune hemolytic anemia (AIHA) attributed to atezolizumab. Management and outcome: Patient was started on a high dose prednisone taper starting at 80 mg daily for 16 days, folic acid 1 mg three times daily, iron sucrose, and darbepoetin alfa. Patient’s counts recovered, and she was able to start Cycle 2 and continued through Cycle 10 without any additional pre-medications. Discussion Hemolytic anemia induced by atezolizumab is a rare side effect that was successfully treated in this patient with a prednisone taper.
Exemestane induced cholestatic liver injury – A case report
Authors: Fritzsche Dane , Indorf Amy , Miske Abby , Banda Kalyan 
Published: September 2020

Purpose Exemestane, a steroidal aromatase inhibitor, is an important therapeutic option in the treatment of post-menopausal hormone receptor positive breast cancer. Adverse effects include hot flashes and bone loss, but rarely is hepatotoxicity reported. We report a case of exemestane induced cholestatic liver injury following exemestane initiation. Case report A now 77-year-old Caucasian female with primary biliary cirrhosis (PBC), and metastatic hormone receptor positive breast cancer originally diagnosed in 2000 who developed symptoms of pruritus, diarrhea, grade 2 transaminitis, and grade 1 hyperbilirubinemia three weeks after exemestane initiation. Management and outcome: Due to the patient’s signs and symptoms, exemestane was discontinued and the patient was continued on cholestyramine until resolution of her laboratory abnormalities. Approximately a week after discontinuation, the patient was started and maintained on anastrozole without recurrence of her symptoms. Discussion Hepatotoxicity with aromatase inhibitors have rarely been reported in clinical trials and to date, instances of exemestane induced hepatotoxicity has only been reported in two case reports. The patient’s history of primary biliary cirrhosis may be an important risk factor for the development of hepatotoxicity from exemestane.
Outcomes with enoxaparin dose reductions during thrombocytopenia in patients with hematopoietic stem cell transplantation (HSCT)
Authors: Lam Jenna , Tavares Erica , Luk Samantha O 
Published: September 2020

Introduction Appropriate dosing of therapeutic anticoagulation during periods of thrombocytopenia remains uncertain for patients undergoing hematopoietic stem cell transplants (HSCT). There is a paucity of literature on treatment outcomes for HSCT patients treated with non-prophylactic, but reduced doses of therapeutic anticoagulation during thrombocytopenia. The primary objective was to determine the incidence of major bleeding events during thrombocytopenia when reduced-dose enoxaparin was administered. Methods This is a retrospective review of patients with a venous thromboembolic event (VTE) who underwent HSCT and received reduced-dose enoxaparin during thrombocytopenia at the Massachusetts General Hospital (MGH) from April 1, 2016 to August 31, 2018. Incidence of recurrent VTE and bleeding events for up to one month were investigated. Rates of recurrent VTE and enoxaparin dose adjustments (0.5 mg/kg twice daily vs 1 mg/kg daily) were also reviewed. Results Out of 172 patients reviewed, 27 patients met inclusion criteria. There were no recurrent VTEs within one month of initial enoxaparin dose reduction. There was one major bleeding episode that occurred while a patient was on full-dose enoxaparin; believed to be related to cyclophosphamide cardiopulmonary toxicity and resulted in death. There were six non-major bleeding episodes, only one of which was clinically significant and resulted in the discontinuation of enoxaparin. Conclusion Our evaluation of therapeutic enoxaparin dose reductions for thrombocytopenia in the HSCT patient population found this practice to be effective in reducing the recurrence of VTE with no major bleeding adverse events. However, the rate of non-significant minor bleeds should be monitored while on reduced-dose enoxaparin.
Can Increased Recovery Rates from Coronavirus be explained by Prevalence of ADHD? An Analysis at the US Statewide Level
Authors: Arbel Yuval , Fialkoff Chaim , Kerner Amichai , Kerner Miryam 
Published: September 2020

Previous research demonstrates that ADHD is considered a risk factor for COVID-19. The current study attempts to investigate the relationships between infection, mortality and recovery rates from coronavirus and the prevalence of ADHD at the US statewide level. Based on information from 2011 regarding the prevalence of ADHD across the US by state, findings suggest that, while there are no correlations between ADHD and population size, infection and mortality rates from coronavirus, recovery rates (recovery-population ratio) rise with the prevalence of ADHD. Consequently, a possible explanation is that in coping with the disease, ADHD might provide an evolutionary advantage. An example of this phenomenon can be found in the gene that causes sickle-cell disease, which, as a non-dominant gene, helps cope with infection from malaria. If corroborated, research findings may support the conclusion that coronavirus limitations in special educational frameworks for ADHD would not be required or could be relaxed. JEL Codes: H75, I12
Topical insulin for refractory persistent corneal epithelial defects
Authors: Diaz-Valle David , Burgos-Blasco Barbara , Gegundez-Fernandez Jose A , Garcia-Caride Sara , Puebla-Garcia Virginia , Peña-Urbina Pilar , Benitez-del-Castillo Jose M 
Published: September 2020

Purpose: To evaluate insulin eye drops for persistent epithelial defects (PEDs) that are refractory to usual treatment in clinical practice and to analyze how it may improve epithelization. Methods: A prospective non-randomized hospital-based study was performed. Patients with PEDs that were refractory to conventional treatment were treated with insulin eye drops four times a day. Patients’ demographics, PED etiology, concomitant treatments, and comorbidities were reviewed. The rate of PED closure and epithelial healing time were considered the primary outcome measures. Results: 21 patients were treated with insulin drops (12 females and 9 males; mean age 72.2 years). Mean PED area before treatment was 17.6 ± 16.5 mm2 (median 13.2; range 3.9–70.6). PED comorbidities included seven eyes with infectious keratitis (33%), five eyes with calcium keratopathy (24%), ocular surgery on three eyes (14%), three eyes with lagophthalmos (14%), two eyes with bullous keratopathy (10%), and one patient with herpetic eye disease (5%). The eyes of 17 patients (81%) with refractory PEDs had reepithelized and four patients (19%) had still presented an epithelial defect by the end of the study follow-up period, although it had decreased in size. In patients where PED closure was achieved, mean time until reepithelization was 34.8 ± 29.9 days (median 23; range 7–114). In the remaining patients, a mean area reduction of 91.5% was achieved for the PEDs. Conclusion: Topical insulin can promote and accelerate corneal reepithelization of refractory PEDs. It also offers many other advantages, including excellent tolerance, availability, and cost-effectiveness.
Validating vascular access data in the Swedish Renal Registry SRR
Authors: Welander Gunilla , Sigvant Birgitta 
Published: September 2020

Background: All Swedish dialysis units register data on vascular access in the Swedish Renal Registry (SRR). This study assessed external and internal validity of vascular access data in the SRR and its use as a tool in clinical practice. Methods: For external validation, all procedures for placed fistulas, open and endovascular reinterventions registered in the SRR in 2011 to 2017 were cross-matched with data from the Swedish National Patient Registry. A two-stage sampling selected 12/60 dialysis units for internal validation. Data on current vascular access for 10 randomly selected patients at each unit were compared with medical record data. SRR data on placed fistulas from 2017 were cross-checked with data from local surgical units. Registrations of central venous catheters (CVCs) as temporary or permanent were used as a proxy for clinical utilization of the registry and analyzed separately. Results: External validity increased from 74% to 83% during the observation period. In all, 1037 datapoints were used in internal validation, with a 95% match between SRR registrations and medical records. Registrations of CVCs, fistulas, and interventions were reliable, with few missing data or mismatches. Vascular access type initiating hemodialysis was missing or incorrect in either the SRR or medical records for 14/120 patients. Registrations of placed fistulas in 2017 matched in all but four (pre-dialysis stage) of 135 cases. Some 35% of the CVCs validated ( n = 49) at 7/12 units were not categorized as temporary or permanent. Conclusion: The SRR provides a reliable resource on current vascular access care.
Freedom to Work: The Impact of Wireless on Labour Politics
Authors: Gregg Melissa 
Published: September 2020

As the use of wireless communication technologies begins to settle into particular patterns, this essay considers the impact of such devices on workplace culture — particularly that of the professional middle class engaged in information work. While the study of workplace culture is usually the domain of sociology, management theory or organisational behaviour, media and cultural studies methods such as semiotic and discourse analysis, media consumption and theories of everyday life have a useful role to play in understanding how technology is marketed and subsequently used in and outside work contexts. As a starting point for this kind of approach, the paper combines an account of recent wireless advertising in Australia with research that is developing in ‘production-side cultural studies’ (Liu, 2004; Du Gay, 1997). In recognising the significance of new media technologies in contemporary labour practice and politics, it aims to move discussions beyond the notion of ‘work–life balance’ as a research endpoint to allow more variegated notions of freedom and flexibility for the workplaces of the present and near future. We feel free only because we lack the language to describe our unfreedom. — Slavoj Zizek, Welcome to the Desert of the Real
Development and preliminary validation of a depressive symptomatology detection scale among children and adolescents on the autism spectrum
Authors: Bellalou Lucie , Downes Naomi , Cappe Emilie 
Published: September 2020

High rates of depressive disorders are reported among young people on the autism spectrum. This condition is generally assessed using measures validated for typically developing young people. Tools adapted to children on the autism spectrum are not tailored to detect Major Depressive Disorder, nor have they been used among samples with an intellectual disability. To fill this gap, this article builds a novel Scale for evaluating depressive symptoms among youth on the autism spectrum ( Echelle d’évaluation de la symptomatology dépressive spécifique à l’autisme) and evaluates its performance using a sample of 153 young people on the autism spectrum in France. The Echelle d’évaluation de la symptomatology dépressive spécifique à l’autisme was completed by parents of children and adolescents (aged 3–17 years) via an interview with a psychologist. The Echelle d’évaluation de la symptomatology dépressive spécifique à l’autisme has very good internal consistency, as well as good content validity. The scale is composed of two factors: (1) behavioral changes and (2) emotional and cognitive changes. Future studies should replicate this validation study with a larger sample size and investigate interrater reliability. Overall, results suggest preliminary support for using the Echelle d’évaluation de la symptomatology dépressive spécifique à l’autisme among youth on the autism spectrum. Lay abstract Many individuals on the autism spectrum experience depressive symptoms. These symptoms contribute to poor quality of life and may have a more negative impact than core autistic features. However, identifying depressive symptoms among individuals on the spectrum is a real challenge. In this study, we investigate the psychometric qualities of a French scale for evaluating depressive symptoms among youth on the autism spectrum. Participants were 153 autistic children and adolescents aged between 3 and 17 years. The majority of the sample was male (73.86%). One of their parents completed the scale for evaluating depressive symptoms among youth on the autism spectrum during an interview with a psychologist. Overall, the findings indicate the scale may be reliably used with children and adolescents on the autism spectrum. Experts deemed the items as being representative of depressive symptoms. The scale is composed of two factors: behavioral changes on one hand and cognitive and emotional changes on the other. The results are encouraging and show the scale is a promising instrument for assessing Major Depressive Disorder symptomatology among youth on the spectrum. Future studies should focus on testing this scale among adults and developing an auto-evaluative section.
Minor aortic injury may be at risk of progression from uncontrolled shear stress: An in-vitro model demonstrates aortic lesion expansion
Authors: Rabin Joseph , Siddiqui Ahmed , Gipple Jenna , Taylor Bradley , Scalea Thomas M , Haslach Henry W 
Published: September 2020

Background Non-operative management is considered appropriate treatment for minor aortic injury, while blood pressure and anti-impulse therapy are routinely utilized to prevent higher grade aortic injury progression. However, a universal medical regimen for low grade intimal injuries has not been adopted and risks of low-grade injury progression not well described. The purpose of this study is to determine the fracture response of minimally damaged aortic tissue to the various applied forces. Our hypothesis is that internal circumferential shear within the aortic wall is a primary fracture mode. This knowledge may help guide clinical management to minimize risk of injury progression, including instituting standard medical regimens with anti-impulse therapy and β-blockade for such minor injuries. Methods Human ascending aortic tissue was obtained after aneurysm repair or heart transplant, stored at 4°C and tested within 48 hours. Minor injury was modeled with a small radial notch on the luminal aspect of aortic rings, circumferentially expanded under video acquisition and analyzed to determine lesion propagation. Results 15 rings were obtained from 8 aneurysmal and 4 healthy aortas. All specimens demonstrated circumferential crack propagation. Propagation was longer (8.02 ± 5.92 mm vs 2.70 ± 1.23 mm) and initiation of crack propagation earlier in aneurysmal tissue (1.54 ± 0.17 versus 1.90 ± 0.17 times initial diameter). Conclusions Dilation of minimally injured aortic rings is associated with lesion expansion and injury progression in all specimens including healthy and aneurysmal tissue. This propagation illustrates the mechanical response to increased levels of internal shear, compromising structural integrity and increasing risk of aortic rupture in all injured aortas. Shear forces are routinely generated through normal circumferential aortic expansion with each pulsation, the magnitude of these forces determined by pulse and blood pressure. This suggests minor aortic injuries are not trivial and strategies to reduce shear stress be implemented in all such patients without contraindications to β- blockers.
Clinical validation of 2D perfusion angiography using Syngo iFlow software during peripheral arterial interventions
Authors: Verschuur Anouk S , Groot Jebbink Erik , Lo-A-Njoe Pascal E , van Weel Vincent 
Published: September 2020

Objective Endovascular surgery is an important treatment modality in peripheral arterial disease. Digital subtraction angiography is the standard post revascularisation diagnostic tool to locate lesions and to evaluate the effect of an intervention. However, interpretation of digital subtraction angiography images is subjective and it is difficult to determine whether revascularisation has been sufficient for clinical improvement. A new technique is 2D perfusion angiography, which creates a 2D colour map and time density curve from the digital subtraction angiography scan for an objective evaluation of the results. However, its clinical relevance is unknown. The aim is to evaluate the association between 2D perfusion angiography parameters and clinical outcome after peripheral arterial interventions. Methods In this retrospective study, post revascularisation angiographic data and clinical data were reviewed of patients who underwent treatment of femoral-popliteal or femoral-tibial arteries. The outcome was assessed at three time points using three classification systems for peripheral arterial disease: Fontaine classification, American Medical Association whole person impairment classification (AMA) and average wound, ischemia, foot infection score. Post revascularisation angiographic data consisted of time density curves of the foot and lower leg which were extracted from the Syngo iFlow system (Siemens Healthineers). For each time density curve, five descriptive parameters were calculated: time of arrival, time to peak, mean transit time, wash-in rate and area under the curve. The association between the time density curve parameters and peripheral arterial disease classification systems was assessed using a regression analysis. Results Between July 2016 and December 2018, 103 patients underwent peripheral endovascular interventions in the hybrid operating room; 39 patients were suitable for analysis, of which 28 patients underwent digital subtraction angiography of the lower leg, 3 patients underwent digital subtraction angiography of the foot and 8 patients underwent digital subtraction angiography of both regions. Limited significant relations were found for time of arrival with Fontainde classification (B = 0.806, p = 0.043) and area under the curve with AMA classification (B = −0.027, p = 0.047). Conclusion In this retrospective study, time density curve parameters (time of arrival and area under the curve), measured in the lower leg, showed a limited significant association with two classification systems for peripheral arterial disease. Future prospective studies to determine the clinical relevance of this 2D perfusion angiography method should focus on standardisation of angiography protocols and comparison of pre- and post-intervention parameters.