bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact ofNOD2Genetic Variants on the Gut Mycobiota in Crohn’s Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation
Authors: Nelson Andrew , Stewart Christopher J , Kennedy Nicholas A , Lodge John K , Tremelling Mark ,   UK IBD Genetics Consortium, Probert Chris S , Parkes Miles , Mansfield John C , Smith Darren L , Hold Georgina L , Lees Charlie W , Bridge Simon H , Lamb Christopher A 
Published: October 2020

AbstractBackground and AimsHistorical and emerging data implicate fungi in Crohn’s disease [CD] pathogenesis. However, a causal link between mycobiota, dysregulated immunity, and any impact of NOD2 variants remains elusive. This study aims to evaluate associations between NOD2 variants and faecal mycobiota in CD patients and non-CD subjects.MethodsFaecal samples were obtained from 34 CD patients [18 NOD2 mutant, 16 NOD2 wild-type] identified from the UK IBD Genetics Consortium. To avoid confounding influence of mucosal inflammation, CD patients were in clinical remission and had a faecal calprotectin &lt;250 μg/g; 47 non-CD subjects were included as comparator groups, including 22 matched household [four NOD2 mutant] and 25 non-household subjects with known NOD2 genotype [14 NOD2 mutant] identified by the NIHR BioResource Cambridge. Faecal mycobiota composition was determined using internal transcribed spacer 1 [ITS1] sequencing and was compared with 16S rRNA gene sequences and volatile organic compounds.ResultsCD was associated with higher numbers of fungal observed taxonomic units [OTUs] [p = 0.033]. Principal coordinates analysis using Jaccard index [p = 0.018] and weighted Bray-Curtis dissimilarities [p = 0.01] showed Candida spp. clustered closer to CD patients whereas Cryptococcus spp. clustered closer to non-CD. In CD, we found higher relative abundance of Ascomycota [p = 0.001] and lower relative abundance Basidiomycota [p = 0.019] phyla. An inverse relationship was found between bacterial and fungal Shannon diversity in NOD2 wild-type which was independent of CD [r = -0.349; p = 0.029].ConclusionsThis study confirms compositional changes in the gut mycobiota in CD and provides evidence that fungi may play a role in CD pathogenesis. No NOD2 genotype-specific differences were observed in the faecal mycobiota.
Long-Distance Migration of the Globe Skimmer Dragonfly to Japan Revealed Using Stable Hydrogen (δ 2H) Isotopes
Authors: Hobson Keith A , Jinguji Hiroshi , Ichikawa Yuta , Kusack Jackson W , Anderson R Charles 
Published: October 2020

Abstract
The globe skimmer dragonfly, Pantala flavescens Fabricius (Odonata: Libellulidae), is a long-distance migrant, well adapted to exploiting ephemeral waterbodies. This species occurs in Japan every summer, but overwintering has only been recorded on subtropical Ishigaki Island. It is not known from where the summer immigrants originate, nor what proportion of the globe skimmers seen in Japan are of local origin. We analyzed stable hydrogen isotope (δ 2H) composition of wings of 189 P. flavescens captured at six sites in Japan from August to September in 2016 (n = 57) and from April to November in 2017 (n = 132). We determined that the majority of individuals were immigrants. Individuals of probable Japanese origin occurred only later in the year and were of lower mass on average than immigrants. Immigrants potentially originated from a broad area as far west as northern India and the Tibetan Plateau and, especially late in the season, as near as northcentral China and the Korean peninsula. However, for April samples, the most parsimonious interpretation suggested southern origins, in northern Myanmar to southern China, or possibly Borneo-Sulawesi. Our investigation underlines the power of combining stable isotope data with other information such as wind speed and direction, arrival dates, and body mass to estimate origins and to understand the life history of this and other insects.
Chronic Pain and Friendship Among Middle-Aged and Older U.S. Adults
Authors: Yang Yulin , Grol-Prokopczyk Hanna 
Published: October 2020

Abstract

Objectives
This study examines how chronic pain affects friendship in later life. We test whether onset of pain leads to social network activation, as suggested by research on other health conditions, or whether pain—an unverifiable and often stigmatizing condition—functions as a “threat to the social self”.

Method
Using longitudinal data from the Health and Retirement Study (HRS; N = 4,598; 2006/2008 as Time 1 and 2010/2012 as Time 2), we conducted OLS regressions with a lagged dependent variable approach to assess how new-onset chronic pain predicted (a) respondents’ number of close friends and (b) their frequency of in-person meetings with friends, controlling for sociodemographic variables and health conditions.

Results
New-onset severe pain predicted a decrease in number of friends. New-onset moderate pain, in contrast, predicted more friends and more frequent in-person meetings. (Findings were significant or marginally significant depending on model specifications.) Mild pain showed no significant association with either outcome. Pain had a greater effect on men’s friendship outcomes than women’s.

Discussion
The effects of chronic pain on later-life friendships appear to depend on pain severity, and to differ between men and women. Onset of severe pain serves as a “threat to the social self,” while onset of moderate pain contributes to social network activation; both associations are significantly more pronounced among men. These findings highlight the complex associations between health and social outcomes.
Contextualizing the COVID-19 Era in Puerto Rico: Compounding Disasters and Parallel Pandemics
Authors: García Catherine , Rivera Fernando I , Garcia Marc A , Burgos Giovani , Aranda María P 
Published: October 2020

AbstractObjectivesThe COVID-19 outbreak has worsened the ongoing economic crisis in Puerto Rico by creating “parallel pandemics” that exacerbate socioeconomic and health inequalities experienced by its most vulnerable residents. Unfortunately, conditions on the island have been largely overlooked by national media outlets and the mainland U.S. population. Thus, this research report aims to draw attention to the disparate burden multiple and compounding disasters have on older island-dwelling Puerto Rican adults’ health and well-being.MethodsWe characterize the lived experiences of the older population in Puerto Rico by incorporating data from multiple sources and contextualizing the effects of compounding disasters, the fiscal pandemic, and health care challenges to provide a more nuanced portrait of existing compounding factors that negatively affect the health and well-being of older adults in the era of COVID-19.ResultsWe highlight 2 main factors that exacerbate pre-pandemic inequities experienced by the older adult population amid the COVID-19 pandemic in Puerto Rico: (a) the impact of multiple and compounding disasters; and (b) health care challenges.DiscussionThe human suffering of the Puerto Rican population is compounded by the consequences of fiscal austerity, increasing levels of income and wealth inequality, the debt crisis, significant emigration, and a dysfunctional health care system. Future governmental actions are required to lessen the burden of parallel pandemics on older adults in Puerto Rico.
Genomic Landscape of Early-stage Colorectal Neoplasia Developing From the Ulcerative Colitis Mucosa in the Japanese Population
Authors: Matsumoto Kenta , Urabe Yuji , Oka Shiro , Inagaki Katsuaki , Tanaka Hidenori , Yuge Ryo , Hayashi Ryohei , Kitadai Yasuhiko , Arihiro Koji , Shimamoto Fumio , Tanaka Shinji , Chayama Kazuaki 
Published: October 2020

Abstract

Backgrounds
Colorectal neoplasias (CRN)s developing from the ulcerative colitis (UC) mucosa include both colitic and sporadic neoplasias. Although several genomic analyses of advanced colitis-associated cancer are available, such studies do not distinguish between colitic and sporadic cases, and the early-stage genomic alterations involved in the onset of colitic cancer remain unclear. To address this, we performed a genomic analysis of early-stage CRN developing from the UC mucosa (CRNUC).

Methods
We extracted DNA from 36 early-stage CRNUCs (T1 cancer, 10; dysplasia, 26) from 32 UC patients and performed targeted sequencing of 43 genes commonly associated with colitis-associated cancer and compared the results with sequencing data from the Japanese invasive colitis-associated cancer.

Results
The most frequently mutated gene in the CRNUC cohort was APC (mutated in 47.2% of the cases), followed by TP53 (44.4%), KRAS (27.8%), and PRKDC (27.8%). None of the TP53 mutations occurred at any of the hotspot codons. Although the TP53 mutations in The Cancer Genome Atlas of Colorectal Cancer were dispersed throughout the gene, those detected here in CRNUC cases were concentrated in the amino terminal part of the DNA-binding domain. Interestingly, the mutations in KRAS and TP53 were mutually exclusive in CRNUC, and CRNUCs with KRAS mutations had histologically serrated lesions in the gland duct. Mayo endoscopic subscore was higher in TP53-mutated CRNUCs and lower in KRAS-mutated CRNUCs.

Conclusions
Our findings suggest that early-stage CRNUC can be classified into 2 groups: those developing through the carcinogenic pathway via TP53 mutations and those developing through the carcinogenic pathway via KRAS mutations.
Immunosuppressive Therapy and Risk of COVID-19 Infection in Patients With Inflammatory Bowel Diseases
Authors: Burke Kristin E , Kochar Bharati , Allegretti Jessica R , Winter Rachel W , Lochhead Paul , Khalili Hamed , Colizzo Francis P , Hamilton Matthew J , Chan Walter W , Ananthakrishnan Ashwin N 
Published: October 2020

Abstract

Background
The effect of immunosuppressive treatment for immune-mediated diseases on risk of the novel coronavirus disease 2019 (COVID-19) has not been established. We aimed to define the effect of targeted biologic and immunomodulator therapy on risk of COVID-19 in a multi-institutional cohort of patients with inflammatory bowel disease (IBD).

Methods
We identified patients 18 years and older who received care for IBD at Partners Healthcare between January 2019 and April 2020. The primary outcome was development of COVID-19 defined as a positive polymerase chain reaction test for severe acute respiratory syndrome coronavirus 2. Multivariable regression models were used to examine the effect of immunosuppression on risk of COVID-19 and its outcomes.

Results
In a cohort of 5302 IBD patients, 39 (0.7%) developed COVID-19. There was no difference in age, sex, or race between IBD patients with and without COVID-19. The rate of COVID-19 was similar between patients treated with immunosuppression (0.8%) compared with those who were not (0.64%; P = 0.55). After adjusting for age, sex, race, and comorbidities, use of immunosuppressive therapy was not associated with an increased risk of COVID-19 (odds ratio, 1.73; 95% confidence interval, 0.82–3.63). The presence of obesity was associated with a higher risk of COVID-19 (odds ratio, 8.29; 95% confidence interval, 3.72–18.47). There were 7 hospitalizations, 3 intensive care unit stays, and 1 death. Older age and obesity but not immunosuppressive treatment were associated with severe COVID-19 infection.

Conclusions
The use of systemic immunosuppression was not associated with an increased risk of COVID-19 in a multi-institutional cohort of patients with IBD.
COVID-19 emergencies around the globe: China’s experience in controlling COVID-19 and lessons learned
Authors: Jin Hao , Lu Ligong , Liu Junwei , Cui Min 
Published: October 2020

Abstract

Motivation
Nations around the world have been significantly impacted during the COVID-19 pandemic. China’s strategies for controlling COVID-19 offer valuable lessons for the global community. By learning from China’s experience and lessons, other countries could also find appropriate methods to control the pandemic.

Problem statement
What measures has China taken to control the pandemic? What lessons has China learned through this pandemic?

Approach/methods
The literature on China’s lessons and experience in controlling the COVID-19 pandemic was searched and reviewed. Related newspapers and magazines were also searched.

Results
China’s experience can be summed up as establishing temporary hospitals, strict isolation, experts with a knowledge of COVID-19, and measures that increase social distancing.

Conclusions
By learning from the experience of China, other countries in the world could eventually find the methods to control the COVID-19 pandemic. An emergency response system should be established in each country. Doctors and nurses are not alone in fighting COVID-19, and the entire world is helping them. With cooperation, current difficulties could be overcome.
Thirty-day readmission rate of COVID-19 patients discharged from a tertiary care university hospital in Turkey: an observational, single-center study
Authors: UYAROĞLU Oğuz Abdullah , BAŞARAN Nursel Çalik , ÖZIŞIK Lale , DİZMAN Gülçİn Tellİ , EROĞLU İmdat , ŞAHİN Taha Koray , TAŞ Zahİt , İNKAYA Ahmet Çağkan , TANRIÖVER Mıne Durusu , METAN Gökhan , GÜVEN Gülay Saİn , ÜNAL Serhat 
Published: October 2020

Abstract

Background
The 30-day readmission rate is an important indicator of patient safety and hospital’s quality performance. In this study, we aimed to find out the 30-day readmission rate of mild and moderate severity coronavirus disease of 2019 (COVID-19) patients discharged from a tertiary care university hospital and to demonstrate the possible factors associated with readmission.

Methods
This is an observational, single-center study. Epidemiological and clinical data of patients who were hospitalized with a diagnosis of COVID-19 were retrieved from a research database where patient information was recorded prospectively. Readmission data were sought from the hospital information management system and the National Health Information System to detect if the patients were readmitted to any hospital within 30 days of discharge. Adult patients (≥18 years old) hospitalized in COVID-19 wards with a diagnosis of mild or moderate COVID-19 between 20 March 2020 (when the first case was admitted to our hospital) and 26 April 2020 were included.

Results
From 26 March to 1 May, there were 154 mild or moderate severity (non-critical) COVID-19 patients discharged from COVID-19 wards, of which 11 (7.1%) were readmitted. The median time of readmission was 8.1 days (interquartile range [IQR] = 5.2). Two patients (18.1%) were categorized to have mild disease and the remaining 9 (81.9%) as moderate disease. Two patients who were over 65 years of age and had metastatic cancers and hypertension developed sepsis and died in the hospital during the readmission episode. Malignancy (18.7% vs. 2.1%, P = 0.04) and hypertension (45.5% vs. 14%, P = 0.02) were more common in those who were readmitted.

Conclusions
This is one of the first studies to report on 30-day readmission rate of COVID-19 in the literature. More comprehensive studies are needed to reveal the causes and predictors of COVID-19 readmissions.
On Reading Buddhist Vinaya: Feminist History, Hermeneutics, and Translating Women’s Bodies
Authors: Langenberg Amy Paris 
Published: October 2020

AbstractBuddhist monastic law codes (vinaya) are rich sources for writing the history of the early nuns’ community. If we hope to encounter these ascetic women of long ago as full real people, however, we must apply an intentional, transparent, critically informed, and sometimes interstitial reading strategy, not a theoretically naïve historiography cloaked in philological rigor. Confronting head on the issue of what the vinaya actually can tell us about the early nuns’ community, this essay offers a survey of hermeneutical approaches in vinaya studies. It articulates a revised approach based on accepted strategies within vinaya studies enhanced by innovations in the fields of religious studies, gender studies, historical linguistics, comparative law, and dharmaśāstra studies. It also analyzes several vinaya passages based on this revised approach, including a text legislating the nuns’ use of what appears to be an ancient tampon when they are menstruating. Finally, it offers observations about the possible relationship between nuns’ vinayas as texts and the realia of the early nuns’ community. These observations include the possibility that the ancient Buddhist nunnery was a place where monastic women exercised certain types of agency as practitioners, interpreters, and even authors of monastic discipline, despite their oft-mentioned subordination to the male community.
Interdisciplinary Representation of Burn Surgery Journal and Society Leadership
Authors: Kettering Caroline E , Erpenbeck Sarah P , Stofman Guy M , Ziembicki Jenny A , Egro Francesco M 
Published: October 2020

Abstract
Burn care is a complex craft that requires an interdisciplinary approach. It includes a diverse array of specialty providers to provide holistic, specialized care to burn victims. This study aims to evaluate the diverse array of subspecialties involved in burn surgery journal and society leadership. A cross-sectional study was conducted in July 2019 by examining the characteristics of society and journal leaders. Current governance and committee members of the American Burn Association (ABA) and International Society of Burn Injuries (ISBI) were determined, as well as the editors of five major burn journals. Information gathered included occupation, advanced degrees obtained, and type of residency training. Of 384 editorial board members identified, 76% were physicians (n = 291), with specialties including burn surgery (n = 208, 54%) and anesthesiology (n = 22, 6%). Among nonphysicians (n = 78, 20%), 76% were medical researchers (n = 59), 8% physical therapists (n = 6), and 5% nurses (n = 4). Looking at ABA and ISBI governance (n = 29), 82% were physicians (n = 24). Nonphysician ABA and ISBI leaders were nurses (n = 2, 7%) and occupational therapists (n = 2, 7%). Of 467 identified ABA and ISBI committee members, half were physicians (n = 244, 52%). There was a wide array of nonphysician occupations among committee members, from nurses (n = 99, 21%), to occupational therapists (n = 25, 5%), and even firefighters (n = 6, 1%). Burn surgery journal and society leadership reflect the interdisciplinary nature of burn care by including an array of subspecialties. Yet, physicians tend to dominate academic burn leadership in comparison to other disciplines, highlighting the need for more nonphysician representation in leadership positions.
A Systematic Review on Airbag-Induced Burns
Authors: Erpenbeck Sarah P , Roy Eva , Ziembicki Jenny A , Egro Francesco M 
Published: October 2020

AbstractAirbags significantly reduce fatalities and injuries in automobile crashes, but they have been found to be associated with burns. Specifically, airbags can cause burns through thermal or chemical mechanisms and commonly affect the arms, hands, face, and eyes. While most airbag-induced burns are minor, some may cause unfavorable outcomes. Our study aimed to systematically review airbag-induced burns to assess etiology, type, and treatment of these injuries. A systematic review of case reports pertaining to airbag-induced cutaneous and ocular burns was conducted. Data reviewed included type/location of burns, severity of burn, total number of patients, treatment, complications, and outcome after treatment. We identified 21 case reports that met our inclusion criteria with a total of 24 patients reported in the studies. Of the studies identified, 38% were chemical burns and 25% were thermal burns. Most commonly the upper extremities were burned in 42% of cases, followed by eyes (25%) and face (21%). Most burns identified were superficial partial thickness (58%). Treatment outcomes were good for cutaneous burns, with 95% healing without complication. However, ocular injuries lead to permanent impaired eye function in 71% of cases. In our systematic review, we highlighted the common risk factors, prognosis, and treatment for thermal, chemical, and ocular burns. Airbag-induced burns have a relatively good prognosis but must be recognized and treated immediately to reduce the risk of serious sequelae.
Vascularized Composite Allotransplantation in Burn Reconstruction: Systematic Review and Meta-analysis
Authors: Gray Kelsey M , Peterson Joshua M , Padilla Pablo L , Smith Jeffrey M , Zapata-Sirvent Ramón L , Branski Ludwik K , Norbury William B , Dziewulski Peter 
Published: October 2020

Abstract
Vascularized composite allotransplantation has been successfully employed for burn reconstruction since 2003. However, its safety in this population has been questioned due to high levels of alloimmunization from burn care-related tissue exposures. To investigate this, a systematic review of vascularized composite allotransplantation employed for burn reconstruction was conducted, evaluating literature from January 2000 to September 2019. Articles containing vascularized composite allotransplantation, composite tissue allotransplantation, and burn reconstructive surgery were included; articles without published outcomes were excluded. Observational meta-analysis of pooled mortality and acute rejection episodes relative to allograft type (face vs extremity) and reconstruction type (burn vs non-burn) was performed. Twenty-four of the 63 identified articles met the criteria for inclusion, with 5 more articles added after secondary review. To date, 152 allotransplantations have been performed in 117 patients: 45 face transplants and 107 extremity transplants. Of these, 34 (22%) were performed for burn reconstruction in 25 patients (21%) with an overall higher 1-year mortality rate (12.0% vs 1.1%, P  = .030). Of these deaths, 75% received three or more simultaneous allografts. Additionally, more episodes of acute rejection occurred compared to non-burn patients (4.4 vs 2.4, P  = .035). Vascularized composite allotransplantation performed for burn reconstruction was found to be associated with a greater risk of 1-year mortality and nearly twice the number of episodes of acute rejection. Future studies should seek to identify unique risk factors of burn patients undergoing this operation and evaluate the relationship between antigenic burden and surgical outcomes.
Integrative analysis supports a new species of the Oecomys catherinae complex (Rodentia, Cricetidae) from Amazonia
Authors: Saldanha Juliane , Rossi Rogério Vieira 
Published: October 2020

Abstract
The sigmodontine rodent Oecomys catherinae has been recognized as a species complex that includes five different lineages distributed throughout Brazil south of the Amazon river, named in literature according to their geographic position (central, eastern, northern, western, and westernmost). The western lineage also has been referred as Oecomys aff. catherinae in the literature, because it may represent a distinct species. Herein, we used molecular and morphological data to investigate the possible species distinctiveness within the O. catherinae complex. From molecular analyses, we recovered the western lineage as a monophyletic group with high genetic divergence from the other lineages of the complex. This lineage can be differentiated from other lineages of the O. catherinae complex and other congeners through a combination of mensural and morphological characters that includes: smaller size; posterior margin of nasals usually surpassing the maxillary–frontal suture; supraorbital crest moderately developed, similar to the temporal crest; parietal slightly expanded laterally; subsquamosal fenestra present; alisphenoid strut absent; and anterior cingulum of M1 present. The western lineage occurs in the southern Amazonia, in sympatry with the westernmost lineage and other species of Oecomys. Herein we describe this lineage as a new species, increasing to 19 the number of species within Oecomys.