bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allele‐Specific Quantification of HLA–DRB1 Transcripts Reveals Imbalanced Allelic Expression That Modifies the Amino Acid Effects in HLA–DRβ1
Authors: Chun Sehwan , Bang So‐Young , Ha Eunji , Cui Jing , Gu Ki‐Nam , Lee Hye‐Soon , Kim Kwangwoo , Bae Sang‐Cheol 
Published: October 2020

ObjectiveHLA association fine‐mapping studies have shown the effects of missense variants in HLA–DRB1 on rheumatoid arthritis (RA) susceptibility, prognosis, and autoantibody production. However, the phenotypic effects of expression changes in HLA–DRB1 remain poorly understood. Therefore, we investigated the allele‐specific expression of HLA–DRB1 and its effect on an HLA–DRβ1 structure–associated trait in RA.MethodsWe quantified the allele‐specific expression of each HLA–DRB1 3‐field classic allele in 48 Korean RA patients with anti–citrullinated protein antibodies (ACPAs) and 319 healthy European subjects by using both RNA sequencing and HLA–DRB1 genotype data to calculate the relative expression strength of multiple HLA–DRB1 alleles (n = 14 in Koreans and n = 25 in Europeans) in each population. The known association between ACPA level and alanine at position 74 of HLA–DRβ1 in ACPA‐positive RA was revisited to understand the phenotypic effect of allele‐specific expression of HLA–DRB1 by modeling multivariate logistic regression with the genomic dosage or relative expression dosage of Ala‐74 in 2 independent sets of 1,723 Korean RA patients with ACPA.ResultsThe relative expression strength was highly allele‐specific, causing imbalanced allelic expression in HLA–DRB1 heterozygotes. The association between HLA‐DRβ1 Ala‐74 and ACPA level in RA was better explained by relative expression dosage of Ala‐74 than by the genomic dosage (change in Akaike's information criterion = −6.98). Moreover, the expression variance of Ala‐74 in Ala‐74 heterozygotes with no genomic variance of Ala‐74 was significantly associated with ACPA level (P = 2.26 × 10−3).ConclusionOur findings illustrate the advantage of integrating quantitative and qualitative changes in HLA–DRB1 into a single model for understanding HLA–DRB1 associations.
Compensating the vorticity loss during advection with an adaptive vorticity confinement force
Authors: Zhu Jian , Li Silong , Cai Ruichu , Hao Zhifeng , Huang Guoheng , Sheng Bin , Wu Enhua 
Published: October 2020

AbstractThe advection step in grid‐based fluid simulation is prone to numerical dissipation, which results in loss of detail. How to improve the advection accuracy to preserve more fluid details is still challenging. On the other hand, a common way to enhance smoke details is to use vorticity confinement. However, most of the previous methods simply used a fine‐tuned scale factor ε to adjust the strength of the confinement force, which can only amplify existing vortex details and is easy to cause instability when ε is large. In this article, we proposed an adaptive vorticity confinement method, which does not suffer from the above problems, to compensate the vorticity loss during advection with little extra cost. The main idea is to first calculate a scale factor whose value depends on the vorticity loss during advection, and then use it to adaptively control the vorticity confinement force for vorticity compensation with high stability. The experiment results show the effectiveness and efficiency of our method.
Preprocedural anemia in females undergoing transcatheter aortic valve implantation: Insights from the WIN‐TAVI registry
Authors: Nicolas Johny , Claessen Bimmer E. , Cao Davide , Sartori Samantha , Baber Usman , Power David , Chiarito Mauro , Goel Ridhima , Roumeliotis Anastasios , Chandiramani Rishi , Chen Siyan , Chandrasekhar Jaya , Tchetche Didier , Petronio Anna Sonia , Mehilli Julinda , Lefèvre Thierry , Presbitero Patrizia , Capranzano Piera , Iadanza Alessandro , Sardella Gennaro , Van Mieghem Nicolas M , Meliga Emanuele , Dumonteil Nicolas , Fraccaro Chiara , Trabattoni Daniela , Mikhail Ghada , Ferrer‐Gracia Maria‐Cruz , Naber Christoph , Sharma Samin , Morice Marie‐Claude , Dangas George D. , Chieffo Alaide , Mehran Roxana 
Published: October 2020

AbstractObjectivesTo assess the impact of anemia on clinical outcomes in female patients enrolled in the Women's InterNational transcatheter aortic valve implantation (WIN‐TAVI) registry.BackgroundAnemia is highly prevalent among females who constitute half of TAVI candidates, yet, its clinical significance remains poorly investigated.MethodsPatients were divided into three groups according to preprocedural hemoglobin (Hb) level: (1) no anemia (Hb ≥12 g/dl), (2) mild‐to‐moderate anemia (10 ≤ Hb <12 g/dl), and (3) severe anemia (Hb <10 g/dl). The primary outcome was the occurrence of Valve Academic Research Consortium (VARC)‐2 efficacy endpoint, a composite of mortality, stroke, myocardial infarction (MI), hospitalization for valve‐related symptoms or heart failure or valve‐related dysfunction at 1‐year follow‐up.ResultsHemoglobin level was available in 877 (86.1%) patients: 412 (47.0%) had no anemia, 363 (41.4%) had mild‐to‐moderate anemia, and 102 (11.6%) had severe anemia. The latter group had a higher prevalence of cardiovascular risk factors. Compared with patients without anemia, severe anemia was associated with a greater risk of VARC‐2 efficacy endpoint (adjHR 1.71, 95% CI: 1.02–2.87, p = .04), all‐cause death (adjHR 2.36, 95% CI: 1.31–4.26, p = .004) and a composite of death, MI or stroke (adjHR 1.88, 95% CI: 1.10–3.22, p = .02) at 1 year. Moreover, an increased risk of late mortality (adjHR 1.15, 95% CI: 1.02–1.30, p = .03) was observed with every 1 g/dl decrease in hemoglobin level.ConclusionSevere anemia in females undergoing TAVI was independently associated with increased rates of VARC‐2 efficacy endpoint and mortality at 1 year.
A dedicated Y‐shaped percutaneous ECMO cannula for femoral 2‐in‐1 vascular access during high‐risk procedures
Authors: Modine Thomas , Vincent Flavien , Delhaye Cédric , Van Belle Eric 
Published: October 2020

AbstractHigh‐risk transcatheter procedures requiring hemodynamic support are growing and require multiple vascular access that may be challenging in cases of peripheral artery disease or lack of radial access and exposure to a higher risk of vascular complications. We report the novel utilization of a Y‐shaped arterial extracorporeal membrane oxygenation (ECMO) cannula used as a single femoral access to perform percutaneous coronary intervention (PCI) and aortography during high‐risk transcatheter aortic valve replacement (TAVR). The utilization of this 2‐in‐1 ECMO cannula may simplify vascular access and reduce vascular and bleeding complications during high‐risk ECMO‐supported transcatheter procedures.
Hydrogenation of Alkenes Catalyzed by a Non‐pincer Mn Complex
Authors: Rahaman S. M. Wahidur , Pandey Dilip K. , Rivada‐Wheelaghan Orestes , Dubey Abhishek , Fayzullin Robert R. , Khusnutdinova Julia R. 
Published: October 2020

AbstractHydrogenation of substituted styrenes and unactivated aliphatic alkenes by molecular hydrogen has been achieved using a Mn catalyst with a non‐pincer, picolylphosphine ligand. This is the second reported example of alkene hydrogenation catalyzed by a Mn complex. Mechanistic studies showed that a Mn hydride formed by H2 activation in the presence of a base is the catalytically active species. Based on experimental and DFT studies, H2 splitting is proposed to occur via a metal‐ligand cooperative pathway involving deprotonation of the CH2 arm of the ligand, leading to pyridine dearomatization.
In‐situ Copper Doping with ZnO/ZnS Heterostructures to Promote Interfacial Photocatalysis of Microsized Particles
Authors: Zeng Wei , Ren Yuanfu , Zheng Yuying , Pan Anqiang , Zhu Ting 
Published: October 2020

AbstractCopper‐doped ZnS/ZnO (CSO) hexahedrons in egg tart‐like morphology were fabricated by an in‐situ synthetic strategy to promote photocatalytic hydrogen (H2) production. Hexahedral CuO/ZnO precursors in micro sizes were prepared by a solvothermal method. A subsequent moderate sulfurization of the precursor led to the formation of ZnS/ZnO heterostructures without alteration of the hexahedral morphology. In addition, the in‐situ methodology ensured the homogeneous doping of copper species with ZnS/ZnO heterostructures, which significantly improved the electric conductivity of these hybrid materials. Because of the structural and compositional features of the hybrid materials, a maximum H2 production rate of 1.044 mmol g−1 h−1 with high recycling stability (even after 12 h) has been delivered based on an interfacial catalysis. Thus, this study may provide an efficient strategy to optimize the physical and chemical properties of photocatalysts in microsize scale.
Adaptations to light predict the foraging niche and disassembly of avian communities in tropical countrysides
Authors: Ausprey Ian J. , Newell Felicity L. , Robinson Scott K. 
Published: October 2020

AbstractThe role of light in partitioning ecological niche space remains a frontier in understanding the assembly of terrestrial vertebrate communities and their response to global change. Leveraging recent advances in biologging technology and intensive field surveys of cloud forest bird communities across an agricultural land use gradient in the Peruvian Andes, we demonstrate that eye size predicts (1) the ambient light microenvironment used by free‐ranging birds, (2) their foraging niche, and (3) species‐specific sensitivity to agricultural land use change. For 15 species carrying light sensors (N = 71 individuals), light intensity levels were best explained by eye size and foraging behavior, with larger‐eyed species using darker microenvironments. Across the cloud forest bird community (N = 240 species), hyperopic (“far‐sighted”) foragers, (e.g., flycatchers), had larger eyes compared to myopic (“near‐sighted”) species (e.g., gleaners and frugivores); eye size was also larger for myopic insectivores that foraged in the forest understory. Eye size strongly predicted sensitivity to brightly lit habitats across an agricultural land use gradient. Species that increased in abundance in mixed intensity agriculture, including fencerows, silvopasture, and pasture, had smaller eyes, suggesting that light acts as an environmental filter when communities disassemble in a human‐disturbed landscape. We suggest that eye size represents a novel functional trait contributing to terrestrial vertebrate community assembly and sensitivity to habitat disturbance.
Heart failure from ATTRwt amyloid cardiomyopathy is associated with poor prognosis
Authors: Kocher Florian , Kaser Alex , Escher Felix , Doerler Jacob , Zaruba Marc‐Michael , Messner Moritz , Mussner‐Seeber Christine , Mayr Agnes , Ulmer Hanno , Schneiderbauer‐Porod Stephanie , Ebner Christian , Poelzl Gerhard 
Published: October 2020

AbstractAimsAmyloid cardiomyopathy is an underappreciated cause of morbidity and mortality. Recent evidence suggests that ATTR wild‐type cardiomyopathy (ATTRwt‐CM) is probably much more common than widely appreciated. So far, no data are available on comparison of mortality from ATTRwt‐CM and other heart failure aetiologies.Methods and resultsThis was a retrospective, observational, cohort study of 2251 patients and their data collected prospectively from May 2000 to June 2018. Long‐term mortality was the main outcome measure. Underlying cardiomyopathies were classified as amyloid CM (6.1%) [ATTRwt 3.0%; light‐chain amyloidosis (AL) 3.1%], dilated CM (dCMP) (46.4%), ischaemic heart disease (IHD) (24.4%), hypertensive heart disease (HHD) (14.6%), hypertrophic CM (HCM) (5.1%), and valvular heart disease (VHD) (3.4%). Median duration of follow‐up was 7.1 years (interquartile range 3.4–11.3). Five‐year overall survival in the whole cohort was 80.1%. In multivariate analysis, individuals with amyloid CM were 3.74 times [95% confidence interval (CI) 2.72–5.14; P < 0.001] more likely to die of any reason than were individuals with dCMP. Mortality was higher in AL‐CM compared with ATTRwt‐CM [hazard ratio (HR) 2.88; 95% CI 1.48–5.58; P = 0.002]. Mortality rates in patients with ATTRwt‐CM were higher than in patients with dCMP (HR 1.96; 95% CI 1.24–3.22; P = 0.007), HCM (HR 2.94; 95% CI 1.28–6.67; P = 0.011), HHD (HR 2.08; 95% CI 1.27–3.45; P = 0.004), VHD (HR 2.38; 95% CI 1.30–4.35; P = 0.005), or left ventricular ejection fraction ≥ 40% (HR 1.99; 95% CI 1.12–3.52; P = 0.018).ConclusionsOur study demonstrates that amyloid CM is independently associated with poor survival among patients with various causes of heart failure. ATTRwt‐CM had a better long‐term prognosis than did AL‐CM, but was associated with higher mortality than were dCMP, HCM, HHD, VHD, and heart failure with preserved or mid‐range ejection fraction.
Accuracy of Doppler blood pressure measurement in HeartMate 3 ventricular assist device patients
Authors: Li Song , Beckman Jennifer A. , Welch Nathan G. , Cheng Richard K. , Rockom Sunny W. , Levy Wayne C. , O'Brien Kevin D. , Dardas Todd F. , Lin Shin , Leary Peter J. , Kirkpatrick James , McCabe James M. , Bjelkengren Jason , Chassagne Fanette , Aliseda Alberto , Zimpfer Daniel , Mahr Claudius 
Published: October 2020

AbstractAimsOptimal blood pressure (BP) control is imperative to reduce complications, especially strokes, in continuous flow ventricular assist device (VAD) patients. Doppler BP has been shown to be an accurate and reliable non‐invasive BP measurement method in HeartMate II and HVAD patients. We examined whether Doppler BP is also accurate in patients with the HeartMate 3 VAD.Methods and resultsIn a prospective, longitudinal cohort of HeartMate 3 patients, arterial line BP and simultaneously measured Doppler opening pressure were obtained. Correlation and agreement between Doppler opening pressure and arterial line mean arterial pressure (MAP) versus systolic blood pressure (SBP) were analysed, as well as the effect of pulse pressure on the accuracy of Doppler opening pressure.A total of 589 pairs of simultaneous Doppler opening pressure and arterial line pressure readings were obtained in 43 patients. Doppler opening pressure had good correlation with intra‐arterial MAP (r = 0.754) and more closely approximated MAP than SBP (mean error 2.0 vs. −8.6 mmHg). Pulse pressure did not have a clinically significant impact on the accuracy of the Doppler BP method. These results in HeartMate 3 patients are very similar to previous results in HeartMate II and HVAD patients.ConclusionsDoppler BP method should be the default non‐invasive BP measurement method in continuous flow VAD patients including patients implanted with the HeartMate 3.
Psychosocial factors associated with pain and sexual function in women with Vulvodynia: A systematic review
Authors: Chisari Claudia , Monajemi Mani B. , Scott Whitney , Moss‐Morris Rona , McCracken Lance M. 
Published: October 2020

AbstractBackground and objectiveVulvodynia is a prevalent chronic vulval pain condition affecting 10%–28% of women, and significantly impacting their health and quality of life. It is currently poorly understood and biomedical treatments achieve only modest benefits for pain and sexual functioning. A wider psychosocial conceptualization of this condition may improve outcomes. There is currently no coherent understanding of how psychosocial factors may contribute to outcomes in Vulvodynia. The aim of this review is to identify and systematically review psychosocial factors associated with pain and sexual outcomes and to inform a psychosocial model of Vulvodynia.Databases and data treatmentObservational/experimental studies reporting on the association between psychosocial factors and pain/sexual outcomes in adult women with Vulvodynia were eligible. Two reviewers independently conducted eligibility screening, data extraction and quality assessment. Twenty‐one studies were included, all focused on women with Provoked Vestibulodynia (PVD). Most of the studies were low‐to‐medium quality.Results/ConclusionA range of general/pain‐related distress and avoidance processes, and sex/intimacy avoidance or engagement processes were significantly associated with pain, sexual functioning or sexual distress and sexual satisfaction, supporting the role of a psychosocial approach to PVD. Depression, anxiety, catastrophizing, pain‐anxiety, pain acceptance, body‐exposure anxiety, attention to sexual cues, partner hostility and solicitousness, self‐efficacy and penetration cognitions are highlighted as potentially important treatment targets in PVD. Due to the limited data available, developing a psychosocial model was not possible. Directions for future research include examining the replicability and generalizability of the factors identified, exploring differences/similarities across Vulvodynia subsets and testing tailored theoretically based treatments.SignificanceThe systematic review highlights the role of psychosocial factors associated with pain and sexual functioning in Vulvodynia. The review findings reveal that Vulvodynia presents both similar and unique cognitive, behavioural and interpersonal features compared to other chronic pain conditions. There may be important roles for negative sexual cues, body image–related factors during intercourse, partner factors, self‐efficacy beliefs and penetration cognitions, in relation to pain and sexual functioning.
Development of Membraneless Paper‐pencil Microfluidic Hydrazine Fuel Cell
Authors: Rao Lanka Tata , Dubey Satish Kumar , Javed Arshad , Goel Sanket 
Published: October 2020

AbstractHerein, a membraneless paper based co‐laminar microfluidic Hydrazine‐Hydrogen peroxide fuel cell, employing graphite pencil electrode, is presented. Hydrogen peroxide has been used as oxidant while sulphuric acid and sodium hydroxide have been employed as electrolytes. The electrodes were formed by manual stroking of graphite pencils. Maximum power output was achieved by examining various combinations of different grades of graphite electrodes on a suitable filter paper with 100 pencil strokes. Here, maximum current density and power density of 14.43 μA/cm2 and 1.30 μW/cm2 respectively were achieved at a stable open circuit potential of 410 mV for 40 mM of hydrazine concentration.
Effects of abdominal emptying and immersion in salt in different concentrations on fatty acids profile and spoilage indices of fish Kotr (Sphyraena jello) during freezing
Authors: Aberoumand Ali , Baesi Farideh 
Published: October 2020

AbstractMany studies showed that the nutritional value and the fish spoilage changed during handle and processing. In this research, 20 pieces of the Kotr fish were purchased from Behbahan market. After washing the fish, some as whole fish were frozen (sample A) and some were descaled and emptied and without salt frozen (sample B) and some were immersed in saltwater with 4% concentrations (sample C), 8% (sample D) and 12% (sample E) which then frozen. After 30 days of freezing, samples were transferred to the laboratory to measure fatty acids profile, spoilage indices, proximate composition, and microbial load. The results showed that the percentage of saturated fatty acids in whole fish was significantly lower than the other treatments. However, the percentage of omega‐3, omega‐6, and MUFA and PUFA fatty acids in different samples did not show a significant difference, but the ratio between DHA/EPA fatty acids changed significantly. Spoilage indexes in Sphyraena jello fillet had a significant difference in process methods. The amount of the indexes decreased with the addition of salt. The addition of salt and the abdominal emptying of S. jello resulted in a change in the fat content of the fish fillet, but did not a significant effect on protein, moisture, and ash content of fish fillet. The number of sycrophile bacteria in treatment A was 158 × 103 Cfu/g, which was higher than the other treatments. The lowest level was observed in salted 12% sample. It can be concluded that abdominal emptying and immersion of the Kotr fish in saltwater can lead to preserve the nutritional value and decrease the spoilage indices and increase the shelf life of the product.
Optimization of Material Contrast for Efficient FIB‐SEM Tomography of Solid Oxide Fuel Cells
Authors: Meffert M. , Wankmüller F. , Störmer H. , Weber A. , Lupetin P. , Ivers‐Tiffée E. , Gerthsen D. 
Published: October 2020

AbstractFocused ion beam (FIB) – scanning electron microscopy (SEM) serial sectioning tomography has become an important tool for three‐dimensional microstructure reconstruction of solid oxide fuel cells (SOFC) to obtain an understanding of fabrication‐related effects and SOFC performance. By sequential FIB milling and SEM imaging a stack of cross‐section images across all functional SOFC layers was generated covering a large volume of 3.5·104 μm3. One crucial step is image segmentation where regions with different image intensities are assigned to different material phases within the SOFC. To analyze all relevant SOFC materials, it was up to now mandatory to acquire several images by scanning the same region with different imaging parameters because sufficient material contrast could otherwise not be achieved. In this work we obtained high‐contast SEM images from a single scan to reconstract all functional SOFC layers consisting of a Ni/Y2O3‐doped ZrO2 (YDZ) cermet anode, YDZ electrolyte and (La,Sr)MnO3/YDZ cathode. This was possible by using different, simultaneous read‐out detectors installed in a state‐of‐the‐art scanning electron microscope. In addition, we used a deterministic approach for the optimization of imaging parameters by employing Monte Carlo simulations rather than trial‐and‐error tests. We also studied the effect of detection geometry, detecting angle range and detector type.
A modified trapezoid framework model for partitioning regional evapotranspiration
Authors: Huang Jinhui Jeanne , Chen Han , Li Tingting , McBean Edward , Singh Vijay P. 
Published: October 2020

AbstractWhile evapotranspiration (ET) is normally measured as one hydrologic component, evaporation (E), and transpiration (T) result from different physical‐biological processes. Using a two‐source model, a trapezoid framework has been widely applied in recent years. The key to applying the trapezoid framework model is the determination of the dry/wet boundaries of the land surface temperature‐fractional vegetation coverage trapezoid (LST‐fc). Although algorithms have been developed to characterize the two boundaries, there remains a significant uncertainty near the wet boundary which scatters in a discrete and uneven manner. It is therefore difficult to precisely locate the wet boundary. To address this problem, a Wet Boundary Algorithm (WBA) was developed in this study with the algorithm applied in the region of Huang‐Huai‐Hai plain of China, using the Pixel Component Arranging and Comparing Algorithm (PCACA) to retrieve ET from MODerate‐resolution Imaging Spectroradiometer (MODIS) Data. The eddy covariance (EC) measurements from Yucheng station was used to verify the modified model where the root mean square error (RMSE) of 17.8 W/m2, Bias of −7.2 W/m2 for latent heat flux (LE) simulation in 28 cloudless test days. The ratio of transpiration to evapotranspiration (T/ET) varied between 0.48 and 0.81 over the Huang‐Huai‐Hai plain. The spatial and temporal distribution of ET revealed that agriculture practices have a significant influence on the hydrological cycle, where crop growth promotes the magnitude of ET. Likewise, harvesting activities significantly reduce ET. The proposed WBA algorithm significantly reduces the uncertainty of the trapezoid ET model caused by wet edge positioning. The analysis of the impact of agricultural activities on ET provide a better understanding how human activities change the hydrological cycle at regional scales.