bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПРОФЕСІЙНА ПІДГОТОВКА МАЙБУТНІХ ЛОГОПЕДІВ ЯК МЕДИЧНА І ПЕДАГОГІЧНА ПРОБЛЕМА В ІСТОРИЧНОМУ КОНТЕКСТІ
Authors: Melnychuk I. M. 
Published: December 2019

У статті аргументовано, що державницький підхід в Україні до врахування проблем у розвитку осіб з проявами деструктивних змін у психофізіологічному та фізичному розвитку спрямовує до розширення інклюзивної освіти. До групи фахівців, які працюють у сфері інклюзивної освіти, відносяться логопеди, покликані вирішувати проблеми мовленнєвих розладів різної складності, починаючи з дитячого віку. Історичний екскурс-аналіз свідчить, що проблема порушень мовлення розглядалася ще філософами, медиками, риторами Стародавнього Світу в сукупності з питаннями світогляду, збереження здоров’я і виховання людини. Історичний аналіз наукової літератури засвідчує, що з моменту зародження логопедії як науки спостерігалася її диференціація на дві галузі – медичну і педагогічну, що й зумовлює постійну спільну участь і лікарів, і педагогів у вивченні етіології, симптоматології і терапії порушень мовлення. Сучасні статистичні дані свідчать, що в Україні існує проблема забезпеченості фахівцями, які мають професійну підготовку логопеда. Тому на державному рівні визначено короткострокові та середньострокові перспективи розвитку інклюзивної освіти, в яких відображено і проблему підготовки майбутніх логопедів.
«АПТЕКА ЩАСТЯ» – БЛАГОДІЙНИЙ ЗАХІД ПРОФЕСІЙНОГО ТА МОРАЛЬНО-ЕТИЧНОГО СПРЯМУВАННЯ СТУДЕНТА-ФАРМАЦЕВТА
Authors: Fylypiuk O. M. , Nesteruk T. M. , Shtrimaitis O. V. , Sabadyshyn R. O. 
Published: December 2019

У статті проаналізовано продуктивність роботи професійно-зорієнтованого благодійного заходу «АПТЕКА ЩАСТЯ» для формування професійної компетентності студентів спеціальності «Фармація».
Розробили методологію та принцип роботи «АПТЕКИ ЩАСТЯ» як професійно-зорієнтованої структури. Задекларували асортимент та анотації до «чудодійних» ліків. Залучили студентство до формування асортименту, пакування «чарівних пігулок», а пізніше і до їх реалізації. Вартість «цікавинок» не обмежувалася, всі кошти за реалізовані препарати збирали у спеціальні скриньки та були передані з благодійною метою.
«АПТЕКА ЩАСТЯ» – благодійний захід професійно-зорієнтованого спрямування. Має на меті сформувати стійкі моральні якості майбутнього фармацевтичного працівника: людяність, доброту, милосердя, відповідальність, порядність та доброчинність. Тому повномасштабне залучення студентів до проведення подібних виховних заходів формує соціально активні та творчі особистості, які поєднують у собі високі моральні й етичні принципи та професійну компетентність.
Nas Trilhas da memória
Authors: Santos Adelino Pereira dos , Ferreira Derneval Andrade 
Published: December 2019

O objetivo deste trabalho é apresentar reflexões sobre o lugar da memória na construção da história da luta do povo angolano contra o colonialismo europeu, registrada simbolicamente nas narrativas dos romances Mayombe, de Pepetela, e Noites de Vigília, de Boaventura Cardoso, considerando-se como pressupostos teóricos estudos da História Cultural e da Crítica Literária. Quando se toma o texto ficcional como base de estudos referente à memória, é preciso compreender as diversas vertentes que a literatura assume como instrumento de pesquisa. Nesse caso, o texto literário, dentre outras funções, pode assumir quase um lugar de memória, visto que o texto fictício apresenta certos aspectos que revolvem a memória, contribuindo assim para a ressignificação de papéis, um melhor entendimento cultural e também para reavaliar certas atividades e práticas sociais. Uma primeira versão deste texto foi apresentada como seção de capítulo da tese de doutorado em Estudos Étnicos e Africanos de um dos autores deste trabalho, defendida em 2016.
A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction
Authors: Chen Si , Zhang Yishuai , Lighthouse Janet K. , Mickelsen Deanne M. , Wu Jiangbin , Yao Peng , Small Eric M. , Yan Chen 
Published: December 2019

Background:
Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased heart. However, the roles of PDE10A in cardiovascular biology and disease are largely uncharacterized. The current study is aimed to investigate the regulation and function of PDE10A in cardiac cells and in the progression of cardiac remodeling and dysfunction.

Methods:
We used isolated adult mouse cardiac myocytes and fibroblasts, as well as preclinical mouse models of hypertrophy and heart failure. The PDE10A selective inhibitor TP-10, and global PDE10A knock out mice were used.

Results:
We found that PDE10A expression remains relatively low in normal and exercised heart tissues. However, PDE10A is significantly upregulated in mouse and human failing hearts. In vitro, PDE10A deficiency or inhibiting PDE10A with selective inhibitor TP-10, attenuated cardiac myocyte pathological hypertrophy induced by Angiotensin II, phenylephrine, and isoproterenol, but did not affect cardiac myocyte physiological hypertrophy induced by IGF-1 (insulin-like growth factor 1). TP-10 also reduced TGF-β (transforming growth factor-β)–stimulated cardiac fibroblast activation, proliferation, migration and extracellular matrix synthesis. TP-10 treatment elevated both cAMP and cGMP levels in cardiac myocytes and cardiac fibroblasts, consistent with PDE10A as a cAMP/cGMP dual-specific PDE. In vivo, global PDE10A deficiency significantly attenuated myocardial hypertrophy, cardiac fibrosis, and dysfunction induced by chronic pressure overload via transverse aorta constriction or chronic neurohormonal stimulation via Angiotensin II infusion. Importantly, we demonstrated that the pharmacological effect of TP-10 is specifically through PDE10A inhibition. In addition, TP-10 is able to reverse pre-established cardiac hypertrophy and dysfunction. RNA-Sequencing and bioinformatics analysis further identified a PDE10A-regualted transcriptome involved in cardiac hypertrophy, fibrosis, and cardiomyopathy.

Conclusions:
Taken together, our study elucidates a novel role for PDE10A in the regulation of pathological cardiac remodeling and development of heart failure. Given that PDE10A has been proven to be a safe drug target, PDE10A inhibition may represent a novel therapeutic strategy for preventing and treating cardiac diseases associated with cardiac remodeling.
miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart
Authors: Banavath Hemanth N. , Roman Barbara , Mackowski Nathan , Biswas Debjit , Afzal Junaid , Nomura Yohei , Solhjoo Soroosh , O'Rourke Brian , Kohr Mark , Murphy Elizabeth , Steenbergen Charles , Das Samarjit 
Published: December 2019

Background

Translocation of miR‐181c into cardiac mitochondria downregulates the mitochondrial gene, mt‐
COX
1. miR‐181c/d
−/−
hearts experience less oxidative stress during ischemia/reperfusion (I/R) and are protected against I/R injury. Additionally, miR‐181c overexpression can increase mitochondrial matrix Ca
2+
([Ca
2+
]
m
), but the mechanism by which miR‐181c regulates [Ca
2+
]
m
is unknown.

Methods and Results

By
RNA
sequencing and analysis, here we show that hearts from miR‐181c/d
−/−
mice overexpress nuclear‐encoded Ca
2+
regulatory and metabolic pathway genes, suggesting that alterations in miR‐181c and mt‐
COX
1 perturb mitochondria‐to‐nucleus retrograde signaling and [Ca
2+
]
m
regulation. Quantitative polymerase chain reaction validation of transcription factors that are known to initiate retrograde signaling revealed significantly higher Sp1 (specificity protein) expression in the miR‐181c/d
−/−
hearts. Furthermore, an association of Sp1 with the promoter region of
MICU
1 was confirmed by chromatin immunoprecipitation‐quantitative polymerase chain reaction and higher expression of
MICU
1 was found in the miR‐181c/d
−/−
hearts. Conversely, downregulation of Sp1 by small interfering
RNA
decreased
MICU
1 expression in neonatal mouse ventricular myocytes. Changes in
PDH
activity provided evidence for a change in [Ca
2+
]
m
via the miR‐181c/
MICU
1 axis. Moreover, this mechanism was implicated in the pathology of I/R injury. When
MICU
1 was knocked down in the miR‐181c/d
−/−
heart by lentiviral expression of a short‐hairpin
RNA
against
MICU
1, cardioprotective effects against I/R injury were abrogated. Furthermore, using an in vitro I/R model in miR‐181c/d
−/−
neonatal mouse ventricular myocytes, we confirmed the contribution of both Sp1 and
MICU
1 in ischemic injury.

Conclusions

miR‐181c regulates mt‐
COX
1, which in turn regulates
MICU
1 expression through the Sp1‐mediated mitochondria‐to‐nucleus retrograde pathway. Loss of miR‐181c can protect the heart from I/R injury by modulating [Ca
2+
]
m
through the upregulation of
MICU
1.
Moment Symmetry Models and Decompositions of Symmetry for Multi-way Contingency Tables
Authors: Yoshimoto Takuya , Tahata Kouji , Iki Kiyotaka , Tomizawa Sadao 
Published: December 2019

For square contingency tables, Caussinus[ 1 ] demonstrated that the symmetry model holds if and only if both the quasi-symmetry and marginal homogeneity models hold. Bishop, Fienberg, and Holland[ 2 , p. 307] and Bhapkar and Darroch[ 3 ] provided similar theorems for multi-way tables. The present article proposes a moment symmetry model and unique decompositions of the symmetry model. For two-way tables, the second-order moment symmetry model decomposes the symmetry model into the second-order moment symmetry and marginal homogeneity models, while the [Formula: see text]th-order moment symmetry model decomposes the [Formula: see text]th-order marginal symmetry model using the [Formula: see text]th-order marginal symmetry model for multi-way tables. AMS 2000 subject classification: 62H17
Total Versus Completion Thyroidectomy: A Multidimensional Evaluation of Long-Term Vocal Alterations
Authors: Minni Antonio , Rosati Davide , Cavaliere Carlo , Ralli Massimo , Sementilli Giulio , Gallo Andrea , Brozzetti Stefania , Ossola Paolo , Cavallaro Giuseppe , Bononi Marco 
Published: December 2019

Background: Total thyroidectomy (TT) and completion thyroidectomy (CT) are two common surgical operations that are frequently followed by vocal symptoms despite preservation of the recurrent laryngeal nerve (RLN) and of the external branch of superior laryngeal nerve (EBSLN). The aim of this study was to analyze vocal alterations through endoscopic findings, videolaryngostroboscopy (VLS), acoustic vocal parameters and impact on patients’ quality of life after surgery in the absence of laryngeal nerve injury. Methods: We enrolled 198 patients who underwent thyroidectomy by the same surgeon. One hundred twenty-six patients underwent TT (group TT) while 72 underwent CT (group CT). All patients underwent preoperative VLS and Voice Handicap Index (VHI) assessment and postoperative VHI, VLS and Acoustic Voice Analysis with Multidimensional Voice Program Analysis 12 to 18 months after surgery. Results: We observed a statistically significant higher rate of EBSLN injury in CT compared to TT. Even in the absence of RLN and EBSLN injury, patients who underwent TT and CT presented slightly worse acoustic vocal parameters and VHI scores compared to healthy controls. Interestingly, some acoustic vocal parameters and VHI scores were significantly worse in group CT compared to group TT. Conclusions: The higher rate of EBSLN injury in CT rather than in TT suggests a higher surgical risk in CT. The vocal parameters of loudness and self-perception of voice were significantly worse after CT, suggesting a larger trauma in patients’ vocal outcome in CT if compared to TT, although these alterations were not reported as psychologically limiting daily life of patients. Nevertheless, the existence of multiple factors contributing to vocal alterations after thyroidectomy highlight the importance of a routine comprehensive functional voice analysis before and after surgery.
Radiological Evaluation of a Preoperative First Metatarsal Realignment Test for Metatarsus Primus Varus and Hallux Valgus Correction by the Syndesmosis Procedure
Authors: Wu Daniel Yiang , Lam Eddy Kwok Fai 
Published: December 2019

Background: Metatarsus primus varus correction is one of the primary surgical objectives for hallux valgus correction. Some soft tissue procedures have shown that the first metatarsal can be adequately realigned without osteotomy. The hypothesis of this study was that this correctability should also be demonstrable preoperatively. The purpose of this study was to assess whether a simple forefoot taping technique could do so and whether it could also be correlated with operative results after the syndesmosis procedure. Methods: Between May 2014 and December 2015, 147 feet with hallux valgus from 85 patients with an average age of 46.2 years underwent the syndesmosis procedure. All were followed prospectively with standing radiographic assessment of their first intermetatarsal angle, metatarsophalangeal angle, and medial sesamoid position preoperatively without and with a forefoot wrapping technique and postoperatively at 10 days, 6 months, and 1 year. Results: Their average preoperative intermetatarsal angle was reduced from 14.4 to 8.4 degrees by the wrapping technique, and their average metatarsophalangeal angle was spontaneously reduced from 31.8 to 21.8 degrees. After a minimum 1-year follow-up, they stabilized at 7.4 and 18.6 degrees, respectively. There was significant correlation between hallux valgus and metatarsus primus varus corrections by both forefoot wrapping and surgical methods with Spearman’s rank correlation of metatarsophalangeal angle and intermetatarsal angle corrections ( r = 0.6077, P < .0001 due to the wrapping method; r = 0.7157, P < .0001 due to the syndesmosis procedure). All raw working radiographic images for this study can be viewed in the Supplemental Material section. Conclusion: This study found that a simple forefoot tape-wrapping technique could be used preoperatively to verify first metatarsal mobility for metatarsus primus varus correction by the soft tissue syndesmosis procedure without osteotomies. Level of Evidence: Level II, prospective comparative study.
A qualitative examination of the perceived impact of bureaucratic managerialism on evidence-based practice implementation in Nigeria: a collective case study
Authors: Ominyi Jude N , Agom David A , Ekuma Chidiebere Valentine 
Published: December 2019

Background Evidence-based practice (EBP) is widely recognised as an essential aspect of contemporary healthcare delivery. However, the rise in cost containment and quest for profitability in healthcare management is found to be compromising implementation of evidence-based initiatives aimed at improving care quality. Aims The aim of this work was to examine perspectives of nurses regarding the impact of bureaucratic managerialism on EBP implementation in the Nigerian acute care setting. Methods A qualitative case study methodology was utilised to gather data from two large acute care settings. Drawing on semi-structured interviews, 12 staff nurses, 21 ward managers and 2 nurse managers were interviewed. Data were inductively analysed and themes generated. Results The managerial practice in this context is founded on bureaucratic managerialism, which in turn generated hierarchical constraints that denied nurses the opportunity to self-govern. Implementation of evidence-based initiatives was consequently opposed by the managerial desire to maximise throughput. Conclusions There is need for nurse managers to have greater managerial influence, which would allow opportunities for implementing EBPs to be created. Managerial autonomy for nurse managers would allow them to create enabling environments capable of facilitating successful implementation.
Prevalence, burden, and clinical management of migraine in China, Japan, and South Korea: a comprehensive review of the literature
Authors: Takeshima Takao , Wan Qi , Zhang Yanlei , Komori Mika , Stretton Serina , Rajan Narayan , Treuer Tamas , Ueda Kaname 
Published: December 2019

Abstract
Background
The objective of this review was to determine the unmet needs for migraine in East Asian adults and children.

Methods
We searched MEDLINE and EMBASE (January 1, 1988 to January 14, 2019). Studies reporting the prevalence, humanistic and economic burden, and clinical management of migraine in China (including Hong Kong and Taiwan), Japan, and South Korea were included. Studies conducted before 1988 (before the International Headache Society [IHS] first edition of the International Classification of Headache Disorders) were not included.

Results
We retrieved 1337 publications and 41 met the inclusion criteria (28 from China, 7 from Japan, and 6 from South Korea). The 1-year prevalence of migraine (IHS criteria) among adults ranged from 6.0% to 14.3%. Peak prevalence ranged from 11% to 20% for women and 3% to 8% for men (30- to 49-year-olds). For children, prevalence of migraine increased with age. Information on the economic burden and clinical management of migraine was limited, particularly for children. When reported, migraine was significantly associated with high levels of disability and negative effects on quality of life. Studies suggested low levels of disease awareness/diagnosis within each country. Of individuals with migraine from China, 52.9% to 68.6% had consulted a physician previously, 37.2% to 52.7% diagnosed with headache had not been diagnosed with migraine previously, and 13.5% to 18% had been diagnosed with migraine previously. Of individuals with migraine from Japan, 59.4% to 71.8% had never consulted a physician previously, 1.3% to 7.3% regularly consulted physicians for their headache, and only 11.6% of individuals with migraine were aware that they had migraine. In addition, studies suggested that over-the-counter medication use was high and prescription medication use was low in each country.

Conclusions
This review suggests that there are unmet needs for migraine in terms of sufficient and appropriate diagnosis, and better management and therapies for treatment of migraine in East Asia. The findings are limited by a lack of recent information and significant gaps in the literature. More recent, population-based studies assessing disease burden and clinical management of migraine are needed to confirm unmet needs for migraine across East Asia.
Magnetic Assembly Route to Construct Reproducible and Recyclable SERS Substrate
Authors: Zou Bingfang , Niu Chunyu , Ma Ming , Zhao Lu , Wang Yongqiang 
Published: December 2019

AbstractThe fabrication of a uniform array film through assembly of colloidal building blocks is of practical interest for the integrated individual and collective functions. Here, a magnetic assembly route was put forward to organize monodisperse noble metal microspheres into a uniform array film for surface-enhanced Raman scattering (SERS) application, which demonstrated the integrated signal sensitivity of single noble metal microspheres and reproducibility of their assembled uniform array film. For this purpose, monodisperse multifunctional Fe3O4@SiO2@TiO2@Ag (FOSTA) colloidal microspheres as building blocks were successfully synthesized through a homemade ultrasonic-assisted reaction system. When used in SERS test, these multifunctional microspheres could firstly bind the analyte (R6G) from solution and then assembled into a uniform film under an external magnetic field, which exhibited high SERS detection sensitivity with good reproducibility. In addition, due to the TiO2 interlayer in FOSTA colloidal microspheres, the building blocks could be recycled and self cleaned through photocatalytic degradation of the adsorbed analyte for recycling SERS application.
Prostate cancer screening: assessment of knowledge and willingness to screen among men in Obio Akpor LGA, Rivers State, Nigeria
Authors: Enemugwem Rogers A. , Eze Beatrice A. , Ejike Ukamaka , Asuquo Eme O. , Tobin Alafaka 
Published: December 2019

Abstract
Background
Worldwide prostate cancer is the second most frequent cause of cancer deaths and is the commonest cancer diagnosed among Nigerian men. Screening techniques can be employed to detect the disease earlier in apparently healthy individuals, and increasing evidence shows that this can decrease morbidity and mortality of the disease. The objective of this study was to assess the knowledge and intention to screen for prostate cancer among men in Obio Akpor Local Government Area, Rivers State, Nigeria.

Results
Respondents were within the ages of 40 and 75 years. The most frequently reported source of information about prostate cancer screening was the news media 72 (35.0%) and healthcare workers 62 (30.1%). Thirty (14.9%) of the respondents had good knowledge of prostate cancer, while 80 (39.6%) had good knowledge of prostate cancer screening methods. Concerning prostate cancer screening methods, only 47 (23.3%) were able to correctly identify screening methods for prostate cancer. With regards to intention to screen, 104 (51.5%) were willing to be screened for prostate cancer.

Conclusion
This study showed that the knowledge of prostate cancer was poor with only approximately half of the participants expressing intentions to screen for the disease. This emphasizes the need for the Rivers State Ministry of Health to carry out awareness campaigns on the importance of prostate screening.
Evolution of cis- and trans-regulatory divergence in the chicken genome between two contrasting breeds analyzed using three tissue types at one-day-old
Authors: Wang Qiong , Jia Yaxiong , Wang Yuan , Jiang Zhihua , Zhou Xiang , Zhang Zebin , Nie Changsheng , Li Junying , Yang Ning , Qu Lujiang 
Published: December 2019

Abstract
Background
Gene expression variation is a key underlying factor influencing phenotypic variation, and can occur via cis- or trans-regulation. To understand the role of cis- and trans-regulatory variation on population divergence in chicken, we developed reciprocal crosses of two chicken breeds, White Leghorn and Cornish Game, which exhibit major differences in body size and reproductive traits, and used them to determine the degree of cis versus trans variation in the brain, liver, and muscle tissue of male and female 1-day-old specimens.

Results
We provided an overview of how transcriptomes are regulated in hybrid progenies of two contrasting breeds based on allele specific expression analysis. Compared with cis-regulatory divergence, trans-acting genes were more extensive in the chicken genome. In addition, considerable compensatory cis- and trans-regulatory changes exist in the chicken genome. Most importantly, stronger purifying selection was observed on genes regulated by trans-variations than in genes regulated by the cis elements.

Conclusions
We present a pipeline to explore allele-specific expression in hybrid progenies of inbred lines without a specific reference genome. Our research is the first study to describe the regulatory divergence between two contrasting breeds. The results suggest that artificial selection associated with domestication in chicken could have acted more on trans-regulatory divergence than on cis-regulatory divergence.