bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal linear quadratic Gaussian control for discrete time‐varying system with simultaneous input delay and state/control‐dependent noises
Authors: Lu Xiao , Zhang Qiyan , Liang Xiao , Wang Haixia , Sheng Chunyang , Zhang Zhiguo , Cui Wei 
Published: January 2020

SummaryThis article focuses on the problem of linear quadratic Gaussian (LQG) control for discrete time‐varying system with input delay and state/control‐dependent noises. When the state variables can be exactly observed, first, we obtain the maximum principle by applying the method of variation. Second, a nonhomogeneous relationship between the state and the costate is developed in virtue of the obtained maximum principle and the mathematical induction. It is noted that the nonhomogeneous relationship is the solution to the forward and backward stochastic difference equations (FBSDEs). Finally, based on the solution to the FBSDEs, a necessary and sufficient condition for the optimal LQG control is derived in terms of coupled Riccati equations. Moreover, the analytical expression of the optimal controller is presented. The derived results are applied in networked control systems with packet dropout. Numerical examples are shown to illustrate the effectiveness of the proposed algorithm.
Noninvasive prenatal diagnosis for Duchenne muscular dystrophy based on the direct haplotype phasing
Authors: Chen Min , Chen Chao , Huang Xiaoyan , Sun Jun , Jiang Lu , Li Yingting , Zhu Yaping , Tian Changgeng , Li Yufan , Lu Zhe , Wang Yaoshen , Zeng Fanwei , Yang Yun , Song Xiwei , Peng Zhiyu , Yin Chenghong , Chen Dunjin 
Published: January 2020

AbstractObjectiveWe aimed to investigate the validity of noninvasive prenatal diagnosis (NIPD) based on direct haplotype phasing without the proband or other family members and its feasibility for clinical application in the case of Duchenne muscular dystrophy (DMD).MethodsThirteen singleton‐pregnancy families affected by DMD were recruited. The pathogenic variants in the pregnant females have been identified by multiplex ligation‐dependent probe amplification (MLPA). We resolved maternal haplotypes for each family by performing targeted linked‐read sequencing of their high molecular weight DNA, respectively. Then, we integrated the maternal haplotypes and the targeted sequencing results of maternal plasma DNA to infer the fetal haplotype and the DMD gene variant status. The fetal genotypes were further validated by using chorionic villus sampling.ResultsThe method of directly resolving maternal haplotype through targeted linked‐read sequencing was smoothly performed in 12 participated families, but one failed (F11). The predicted variant status of 12 fetuses was correct, which had been confirmed by invasive prenatal diagnosis.ConclusionDirect haplotyping of NIPD based on linked‐read sequencing for DMD is accurate.
Registration of TN15‐4009 soybean germplasm with resistance to soybean cyst nematode, southern root knot nematode, and peanut root knot nematode
Authors: Pantalone Vince , Wyman Chris 
Published: January 2020

AbstractThe conventional (non‐genetically modified) soybean [Glycine max (L.) Merrill] line TN15‐4009 (Reg. no. GP‐437, PI 691608) was released by University of Tennessee Agricultural Research in 2019 as a germplasm line on the basis of its high seed yield potential in the southern region of the United States and resistance to soybean cyst nematode (SCN), southern root knot nematode, and peanut root knot nematode. The objective of its development was to create a high‐yielding SCN‐resistant soybean line. Progeny rows were selected based on adapted maturity, lodging resistance, disease resistance, and pod density and were entered in yield tests from 2015 through 2018. TN15‐4009 has white flowers and tawny pubescence. The pods have a tan pod wall, and the seed is yellow with a smooth seed coat. The seed size is approximately 13.6 g 100 seed−1, which was significantly greater than that of ‘Ellis’ in the 2018 USDA Uniform Test. In that test, TN15‐4009 matured 1 d earlier than Ellis and the same as ‘AG 4835’, indicating that the relative maturity of TN15‐4009 is approximately 4.8. Soybean line TN15‐4009 is resistant to SCN HG type 5.7 (score = 1) and HG type 2.5.7 (score = 1), resistant to southern root knot nematode (score = 1), and resistant to peanut root knot nematode (score = 1.3). TN15‐4009 is susceptible to stem canker.
Phenotype of children with inconclusive cystic fibrosis diagnosis after newborn screening
Authors: Munck Anne , Bourmaud Aurélie , Bellon Gabriel , Picq Paul , Farrell Philip M. ,   on behalf of the DPAM Study Group
Published: January 2020

AbstractObjectiveTo characterize the phenotypic expression of children with conductance regulator‐related metabolic syndrome (CRMS)/cystic fibrosis screen positive inconclusive diagnosis (CFSPID) designation after positive newborn screening, reassign labeling if applicable and better define these children's prognosis.MethodsA multicenter cohort with CRMS/CFSPID designation was matched with cystic fibrosis (CF)‐diagnosed cohort. Cohorts were prospectively compared on baseline characteristics, cumulative data and when they reached 6 to 7 years at endpoint assessment.ResultsCompared to infants with CF (n = 63), the CRMS/CFSPID cohort (n = 63) had initially lower immunoreactive trypsinogen (IRT) and sweat chloride (SC) values, delayed visits, less symptoms, and better nutritional status; during follow‐up, they had fewer hospitalizations, Pseudomonas aeruginosa and methicillin‐resistant Staphylococcus aureus identification, CF comorbidities, and treatment burden. At endpoint assessment, they presented a milder pulmonary phenotype on Brody computed tomography scores (0.0[0.0; 2.0] vs 13[2.0; 31.0]; P < .0001, respectively), Wisconsin and Brasfield chest radiograph scores, pulmonary function tests, and improved nutritional status. Among the inconclusive CF diagnosis cohort, 28 cases (44%) converted to CF diagnosis based on genotype (44%), SC (28%) or both (28%); yet, comparing those with or without final CF diagnosis, we found no differences, possibly related to their young age and mild degree of lung disease. In the total cohort, we found significant associations between Brody scores and IRT, SC values, genotype, Wisconsin and Brasfield score and spirometry.ConclusionsThe matched CRMS/CFSPID and CF cohorts showed differences in outcomes. By a mean age of 7.6 years, a high proportion of the CRMS/CFSPID cohort converted to CF. Our results highlight that monitoring at CF clinics until at least 6 years is needed as well as further studies.
Using lung ultrasound to quantitatively evaluate pulmonary water content
Authors: Zong Hai‐Feng , Guo Guo , Liu Jing , Bao Lin‐Lin , Yang Chuan‐Zhong 
Published: January 2020

AbstractBackgroundIncreases in extravascular lung water (EVLW) can lead to respiratory failure. This study aimed to investigate whether the B‐line score (BLS) was correlated with the EVLW content determined by the lung wet/dry ratio in a rabbit model.MethodsA total of 45 New Zealand rabbits were randomly assigned to nine groups. Among the animals, models of various lung water content levels were induced by the infusion of different volumes of warm sterile normal saline (NS) via the endotracheal tube. The arterial blood gas, spontaneous respiratory rate, and PaO2/FiO2 ratio were detected before and after infusion. In addition, the B‐lines were determined before and immediately after infusion in each group. Finally, both lungs were resected to determine the wet/dry ratio. In addition, all lung specimens were analyzed histologically, and EVLW was quantified using the BLS based on the number and confluence of B‐lines in the intercostal space.ResultsThe BLS increased with increasing infusion volume. The BLS was statistically correlated with the wet/dry ratio (r2= .946) and with the PaO2/FiO2 ratio (r2= .916). Furthermore, a repeatability study was performed for the lung ultrasound (LUS) technology (Bland‐Altman plots), and the results suggest that LUS had favorable intraobserver and interobserver reproducibility.ConclusionsThis study is the first to suggest that the BLS can serve as a sensitive, quantitative, noninvasive, and real‐time indicator of EVLW in a rabbit model of lung water accumulation. Notably, the BLS displayed an obvious correlation with the experimental gravimetry results and could also be used to predict the pulmonary oxygenation status.
Optically Induced Phase Change for Magnetoresistance Modulation
Authors: Wei Guodong , Lin Xiaoyang , Si Zhizhong , Wang Dong , Wang Xinhe , Fan Xiaofei , Deng Kun , Liu Kai , Jiang Kaili , Lei Na , Chen Yanxue , Mangin Stephane , Fullerton Eric , Zhao Weisheng 
Published: January 2020

AbstractOptical methods for magnetism manipulation have been considered as a promising strategy for ultralow‐power and ultrahigh‐speed data storage and processing, which have become an emerging field of spintronics. However, a widely applicable and efficient method has rarely been demonstrated. Here, the strongly correlated electron material vanadium dioxide (VO2) is used to realize the optically induced phase change for control of the magnetism in NiFe. The NiFe/VO2 bilayer heterostructure features appreciable modulations of electrical conductivity (32%), coercivity (37.5%), and magnetic anisotropy (25%). Further analyses indicate that interfacial strain coupling plays a crucial role in the magnetic modulation. Utilizing this heterostructure, which can respond to both optical and magnetic stimuli, a phase change controlled anisotropic magnetoresistance (AMR) device is fabricated, and reconfigurable Boolean logics are implemented. As a demonstration of phase change spintronics, this work may pave the way for next‐generation opto‐electronics in the post‐Moore era.
Revisiting the lectotype of Daucus mauritanicus L. (Apiaceae)
Authors: Martínez‐Flores Fernando , Crespo Manuel B. 
Published: January 2020

AbstractDaucus mauritanicus L. was described by Linnaeus on the basis of heterogeneous material belonging to two different species. The current lectotype of the name, Herb. Linnaeus No. 340.2 (LINN), is said to be a synonym of D. carota L. However, a close examination of the plant in that voucher reveals that it corresponds undoubtedly to D. muricatus (L.) L., a species lacking a big, dark crimson flower in the centre of the relatively small umbels, which makes it to be in serious conflict with the protologue. A new lectotype, Herb. Linnaeus No. 340.3 (LINN), is therefore designated from among the original material, which agrees with the validating diagnosis and the traditional concept of the species as conspecific with D. maximus Desf.
A pig in a poke management
Authors: Behrens Alfredo , Medeiros Inês 
Published: January 2020

AbstractLatin America might not catch‐up with the United States because U.S.‐styled management, which expresses the North American mindset so well, fails to match the Latin American mindset. The mismatch between mindsets and managerial styles leads to lingering lower productivity among Latin Americans working under North American management regimes. Disregard for the difference in mindsets has to do with ignorance, as in not knowing the Other; as well as arrogance, as in not caring for the Other; and submission, as in failing to stand up. This article draws on literature, history, and anthropology to explain the origin of these differing mindsets, and how they shape the preferences for organizational practices. The article also suggests a blueprint for Latin American management going forward. It requires pursuing corporate alignment through high purposes (profit is a goal, not a purpose), building teams along high‐trust clan lines (non‐clan members are distrusted), blending management into the clan's survival expectations (as in a family), and allowing natural leaders to emerge with enough authority as to earn respect. The article also suggests that the renewed managerial scheme will help to improve the productivity of Latin Americans with joy, a fundamental element (as in pilgrimages) in the Latin American approach to life's endeavors.
The effects of Microcystis aeruginosa cells lysate containing microcystins on physiological and molecular responses in the nematode Caenorhabditis elegans
Authors: Sopezki Mauricio S. , Josende Marcelo E. , Cruz Litiele C. , Yunes João S. , Lima Juliane V. , Zanette Juliano 
Published: January 2020

AbstractMicrocystins (MCs) are potent toxins produced by environmental cyanobacterial blooms. The present study evaluated the effects of a Microcystis aeruginosa cyanobacterial lysate containing 0.1, 1, and 10 μg L−1 MC‐LR equivalent in the C. elegans Bristol N2 wild‐type and the effects caused by equivalent concentrations of a MC‐LR standard. The lysate was prepared from a culture of toxic strain (RST9501) originated from the Patos Lagoon Estuary (RS, Brazil). The minimal concentration necessary to cause significant effects in C. elegans under exposure to M. aeruginosa lysate or to MC‐LR standard were, respectively, 10 and 0.1 μg L−1 MC‐LR equivalent for growth and 10 and 1 μg L−1 MC‐LR equivalent for fertility. Reproduction (ie, brood size) was only affected by the exposure to 10 μg L−1 MC‐LR standard and was not affected by the lysate. The nematodes that were exposed to lysate containing 1 μg L−1 MC‐LR equivalent or MC‐LR were also analyzed for pharyngeal pumping and gene expression using RT‐qPCR. The worms’ rhythmic contractions of the pharynx were similarly affected by the lysate containing 1 μg L−1 of MC‐LR equivalent and the MC‐LR standard. The MC‐LR standard caused down‐regulation of genes related to growth (daf‐16), fertility (spe‐10), and biotransformation (gst‐2). This is the first study to evaluate the effects of a toxic cyanobacterial lysate using the C. elegans model. This study suggests the organism as a potential biotest to evaluate toxicity of natural waters containing M. aeruginosa cells and to environmental risk assessment associated to cyanobacterial bloom events.
Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38‐mediated upregulation of caspase activation
Authors: Chen Yi‐Ching , Chen Pei‐Ni , Lin Chiao‐Wen , Yang Wei‐En , Ho Yu‐Ting , Yang Shun‐Fa , Chuang Chun‐Yi 
Published: January 2020

AbstractCantharidic acid (CA) is the hydrolysis product of the acid anhydride cantharidin, which is a natural toxin secreted by several species of blister beetles. Several studies have indicated that as an inhibitor of protein phosphatase 2 (PP2A), CA induces apoptosis in various human cancer cells. However, the effect of CA on human nasopharyngeal carcinoma (NPC) cells and the underlying pathways have not been addressed. In our current study, we tested the hypothesis that CA treatment reduces the viability of human NPC cells (HONE‐1, NPC‐39, and NPC‐BM) by inducing apoptosis. Results indicated that CA markedly reduced cell viability, which was revealed by the upregulation of caspase activation in extrinsic and intrinsic apoptosis pathways as well as the upregulation of extracellular‐signal‐regulated kinase 1/2 (ERK1/2), p38, and c‐Jun N‐terminal kinase 1/2 (JNK1/2) pathways. Coadministration of a p38 inhibitor (SB203580) with CA abolished the activation of caspase proteins. These findings indicated that CA treatment leads to apoptosis in human NPC cells through the upregulation of caspase activation, mediated particularly by the p38 pathway. Hence, CA is a promising therapeutic agent for human NPC.
The estrogenic proliferative effects of two alkylphenols and a preliminary mechanism exploration in MCF‐7 breast cancer cells
Authors: Wang Xiaoxia , Luo Nao , Xu Zhixiang , Zheng Xianyao , Huang Bin , Pan Xuejun 
Published: January 2020

AbstractBisphenol A (BPA) and 4‐cumylphenol (4‐CP), as estrogen‐like chemicals, are ubiquitous in the environment media and associated with the occurrence and development of hormone‐dependent tumors. However, the combinatorial effects of these two structurally similar alkylphenols are not well informed. In the present study, the classic breast cancer cell line MCF‐7 was used as in vitro model to estimate the estrogenic proliferative effects of BPA and 4‐CP. MTT assay, reactive oxygen species, cell apoptosis, cell cycle, and real‐time fluorescent quantitative Step One Plus Real‐time PCR System (Applied Biosystems, CA, USA) were applied to explore their proliferative mechanisms. MTT results showed that both BPA and 4‐CP ranging from 10−9 to 10−5 M stimulated cell proliferation in a nonmonotonic dose‐response manner. Along with the proliferative effects, cell cycle was progressed from G0/G1 to S and G2/M phase. Meanwhile, the expression levels of ERα, pS2, and Bcl‐2 mRNA were also upregulated. In contrast, 4‐CP and BPA at high dose (10−4 M) obviously displayed antiproliferative effects in MCF‐7 cells via inducing cell apoptosis and blocking cell cycle in G0/G1 phase. As expected, the relative expression levels of ERα, pS2, and Bcl‐2 mRNA were decreased, whereas Bax mRNA was increased. Interestingly, the proliferative or antiproliferative effects of 4‐CP were higher than that of BPA. Moreover, coexposure of lower concentrations BPA and 4‐CP significantly induced cell proliferation in a synergistic manner. These findings indicated that the potential environmental risks of coexposure of BPA and 4‐CP were greater than either of them.
Cytotoxicity, genotoxicity, oxidative stress, and apoptosis in HepG2 cells induced by the imidazole ionic liquid 1‐dodecyl‐3‐methylimidazolium chloride
Authors: Wang Peijin , Wan Ruyan , Huo Weiran , Dong Hui , Chang Zhongjie , Xia Xiaohua 
Published: January 2020

AbstractThis study purposes to assess the cytotoxicity of 1‐dodecyl‐3‐methylimidazolium chloride ([C12min]Cl) in human hepatocellular carcinoma (HepG2) cells. To this end, HepG2 cells were exposed to a range concentration of [C12min]Cl and evaluated cell viability, genotoxicity, oxidative stress, apoptosis, cell cycle, and apoptosis‐related gene expression to determine cytotoxicity. The outcomes showed that [C12min]Cl curbed HepG2 cell growth and reduced cell viability in a concentration‐ and time‐dependent manner. Moreover, our assay results also revealed that exposure to [C12min]Cl prompted DNA damage and apoptosis, reduced SOD and GSH content, enhanced MDA level, and changed the cell cycle of HepG2 cells. In addition, [C12min] Cl caused alters in the expression levels of p53, Bax, and Bcl‐2, indicating that p53 and Bcl‐2 family may be involved in the cytotoxicity and apoptosis of HepG2 cells induced by [C12min]C1. In summary, these results indicate that [C12min]Cl exerts genotoxicity, physiological toxicity and prompts apoptosis in HepG2 cells, and is not an alleged green solvent.
Snow cover variability in Great Britain during a changing climate
Authors: Brown Iain 
Published: January 2020

AbstractRecent research on snow cover patterns over recent decades is reviewed for GB. Interpretation for upland areas is complicated by data availability issues. Nevertheless, two distinct features can be highlighted. Firstly, a general relationship of average yearly snow cover duration with mean temperature. This relationship is apparently non‐linear indicating that snow cover duration is especially sensitive to a defined mean temperature range. Secondly, that snow cover can be rather variable from year to year, or over multi‐year phases. This variability has been related to the frequency of synoptic‐scale atmospheric circulation patterns including the North Atlantic Oscillation. These two features are used to contextualise recent and likely future trends in snow cover. It is suggested that there may be different patterns of variability in some mountain areas compared to the adjacent lowlands. This is associated with combined effects of temperature and precipitation during exposure to different air masses. Suggestions are made for improving snow cover observations to further investigate these issues.
How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post‐infarction patients
Authors: Trayanova Natalia A. , Doshi Ashish N. , Prakosa Adityo 
Published: January 2020

AbstractPrecision Cardiology is a targeted strategy for cardiovascular disease prevention and treatment that accounts for individual variability. Computational heart modeling is one of the novel approaches that have been developed under the umbrella of Precision Cardiology. Personalized computational modeling of patient hearts has made strides in the development of models that incorporate the individual geometry and structure of the heart as well as other patient‐specific information. Of these developments, one of the potentially most impactful is the research aimed at noninvasively predicting the targets of ablation of lethal arrhythmia, ventricular tachycardia (VT), using patient‐specific models. The approach has been successfully applied to patients with ischemic cardiomyopathy in proof‐of‐concept studies. The goal of this paper is to review the strategies for computational VT ablation guidance in ischemic cardiomyopathy patients, from model developments to the intricacies of the actual clinical application. To provide context in describing the road these computational modeling applications have undertaken, we first review the state of the art in VT ablation in the clinic, emphasizing the benefits that personalized computational prediction of ablation targets could bring to the clinical electrophysiology practice.This article is characterized under:Analytical and Computational Methods > Computational MethodsModels of Systems Properties and Processes > Organ, Tissue, and Physiological ModelsTranslational, Genomic, and Systems Medicine > Translational Medicine
libpmemobj-cpp: The Adaptable Language - C++ and Persistent Memory
Authors: Scargall Steve 
Published: January 2020

AbstractThe Persistent Memory Development Kit (PMDK) includes several separate libraries; each is designed with a specific use in mind. The most flexible and powerful one is . It complies with the persistent memory programming model without modifying the compiler. Intended for developers of low-level system software and language creators, the library provides allocators, transactions, and a way to automatically manipulate objects. Because it does not modify the compiler, its API is verbose and macro heavy.