bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a brief motivational intervention to increase the breastfeeding duration in the first 6 months postpartum: Randomized controlled trial
Authors: Franco‐Antonio Cristina , Calderón‐García Julián F. , Santano‐Mogena Esperanza , Rico‐Martín Sergio , Cordovilla‐Guardia Sergio 
Published: November 2019

AbstractAimsTo evaluate the effectiveness of a brief motivational intervention to increase the breastfeeding duration in the first 6 months postpartum in mothers who began breastfeeding in the first hour after birth and to explore the role of general and breastfeeding self‐efficacy in this relationship.DesignA multi‐centre randomized controlled clinical trial.MethodsData were collected from February 2018 ‐ March 2019. Women were randomly assigned to an intervention group that received a brief motivational intervention (N = 44) or a control group that was offered standard education on breastfeeding (N = 44). Survival analysis techniques were carried out with a follow‐up of 6 months. In addition, the roles of breastfeeding and general self‐efficacy in the association between BMI and breastfeeding duration were explored through mediation/moderation analysis.ResultsAmong 88 randomized patients (mean age, 32.82 years), 81 (92.04%) completed the trial. The survival analyses of exclusive breastfeeding and breastfeeding (exclusive and non‐exclusive) showed reductions in the risk of abandonment in the intervention group of 63% (aHR: 0.37 [0.22–0.60] p < .001) and 61% (aHR: 0.39 [0.20–0.78] p = .008), respectively. We found that self‐efficacy acted as a moderator of the effect of brief motivational intervention on breastfeeding self‐efficacy. A discrete indirect effect of brief motivational intervention through increased breastfeeding self‐efficacy was found on breastfeeding duration, with an index of moderated mediation of 0.08 (95% CI: 0.02–0.19). Greater positive variations in the breastfeeding self‐efficacy scores during follow‐up predicted exclusive and non‐exclusive breastfeeding duration.ConclusionA brief motivational intervention conducted in the immediate postpartum period increases breastfeeding and exclusive breastfeeding duration in the first 6 months. Although breastfeeding self‐efficacy seems to moderate the effect of brief motivational intervention on the increase in breastfeeding duration, other factors may influence its effectiveness. Further studies could focus on exploring how brief motivational intervention works and whether it also works for pregnant mothers who have not yet decided whether to breastfeed.ImpactBrief motivational intervention could be introduced as part of routine care of women who begin breastfeeding to improve the low rates of exclusive breastfeeding at 6 months postpartum.Trial registrationUnique Protocol ID: Moti003; https://ClinicalTrials.gov ID: NCT03357549.
A randomized trial of a distraction‐type intervention to assist in managing dressing changes for children experienced burns
Authors: Zhang Xiu‐Hang , Cui Chang‐Lei , Ren Jia‐Ju , Cheng Dan , Wu Wei‐Wei , Yu Jia‐Ao 
Published: November 2019

AbstractAimTo evaluate the impact of the specially designed medical dressing screen during wound dressing changes for children aged 1–3 who experienced a burn on their hand or foot.DesignRandomized controlled trial.MethodsThe study was performed, between January 2019 ‐ April 2019, at a Burn Outpatient Ward. A total of 52 outpatient children who had suffered burns were included in the clinical trial. The burn area of these participants accounted for 1–5% of the total body surface area. The children were randomly divided into two equal‐sized groups, each receiving a different treatment. In the medical screen group (N = 26), a medical screen was used for children during the dressing changes. In the control group (N = 26), the children received only regular dressing changes. Pain level of the children during dressing change was the primary outcome, the satisfaction of children's parents and wound therapist were used as second outcomes. The Bonferroni method was used to perform pairwise comparisons of repeatedly measured data at different measurement times in two groups.ResultsThe results showed that the medical screen group had better outcomes with respect to pain management during dressing changes; in addition, the satisfaction score of the wound therapist and children's parents presented also better outcomes compared with the control group.ConclusionThis study demonstrated application of the medical screen for burns can relieve the pain of 1 ‐ 3‐year old children experienced a burn during dressing changes. In addition, the application of the medical screen also increased the satisfaction of the child's parents and wound therapist.Registration NO: 1,900,020,953.ImpactCompared with conventional dressing methods, the medical screen can be used as a novel way to decrease the negative experience of burn patients ages 1–3 who require dressing changes.
Systematic construction and validation of an immune prognostic model for lung adenocarcinoma
Authors: Luo Chenghan , Lei Mengyuan , Zhang Yixia , Zhang Qian , Li Lifeng , Lian Jingyao , Liu Shasha , Wang Liping , Pi Guofu , Zhang Yi 
Published: November 2019

AbstractLung adenocarcinoma (LUAD), the most common non‐small‐cell lung cancer, is characterized by a dense lymphocytic infiltrate, which indicates that the immune system plays an active role in the development and growth of this cancer. However, no investigations to date have proposed robust models for predicting survival outcome for patients with LUAD in terms of tumour immunology. A total of 761 LUAD patients were included in this study, in which the database of The Cancer Genome Atlas (TCGA) was utilized for discovery, and the Gene Expression Omnibus (GEO) database was utilized for validation. Bioinformatics analysis and R language tools were utilized to construct an immune prognostic model and annotate biological functions. Lung adenocarcinoma showed a weakened immune phenotype compared with adjacent normal tissues. Immune‐related gene sets were profiled, an immune prognostic model based on 2 immune genes (ANLN and F2) was developed with the TCGA database to distinguish cases as having a low or high risk of unfavourable prognosis, and the model was verified with the GEO database. The model was prognostically significant in stratified cohorts, including stage I‐II, stage III‐IV and epidermal growth factor receptor (EGFR) mutant subsets, and was considered to be an independent prognostic factor for LUAD. Furthermore, the low‐ and high‐risk groups showed marked differences in tumour‐infiltrating leucocytes, tumour mutation burden, aneuploidy and PD‐L1 expression. In conclusion, an immune prognostic model was proposed for LUAD that is capable of independently identifying patients at high risk for poor survival, suggesting a relationship between local immune status and prognosis.
CircNr1h4 regulates the pathological process of renal injury in salt‐sensitive hypertensive mice by targeting miR‐155‐5p
Authors: Lu Chaosheng , Chen Bicheng , Chen Congcong , Li Haiyan , Wang Dan , Tan Yi , Weng Huachun 
Published: November 2019

AbstractCircular RNAs are a class of widespread and diverse endogenous RNAs that may regulate gene expression in various diseases, but their regulation and function in hypertensive renal injury remain unclear. In this study, we generated ribosomal‐depleted RNA sequencing data from normal mouse kidneys and from injured mouse kidneys induced by deoxycorticosterone acetate‐salt hypertension and identified at least 4900 circRNA candidates. A total of 124 of these circRNAs were differentially expressed between the normal and injured kidneys. Furthermore, we characterized one abundant circRNA, termed circNr1h4, which is derived from the Nr1h4 gene and significantly down‐regulated in the injured kidneys. RNA sequencing data and qPCR analysis also showed many microRNAs and mRNAs, including miR‐155‐5p and fatty acid reductase 1 (Far1), were differentially expressed between the normal and injured kidney and related to circNr1h4. In vitro, the silencing of circNr1h4 or overexpression of miR‐155‐5p significantly decreased Far1 levels and increased reactive oxygen species. Mechanistic investigations indicated that circNr1h4 acts as a competing endogenous RNA for miR‐155‐5p, leading to regulation of its target gene Far1. Our study provides novel insight into the molecular mechanisms underlying kidney injury in hypertension, which will be required to develop therapeutic strategies of targeting circRNAs for hypertensive kidney injury.
Pathological effects of Cichlidogyrus philander Douëllou, 1993 (Monogenea, Ancyrocephalidae) on the gills of Pseudocrenilabrus philander (Weber, 1897) (Cichlidae)
Authors: Igeh Patience Chwe , Avenant‐Oldewage Annemariè 
Published: November 2019

AbstractHistopathological changes of Cichlidogyrus philander Douëllou, 1993 on the gills of Pseudocrenilabrus philander (Weber, 1897) were studied using light and scanning electron microscopy. Observations revealed that C. philander attaches to its host by alternating the prohaptor (for temporary attachment or feeding) or haptor (using haptoral parts for firm and secured attachment). The sharp terminal ends of the anchors are inserted basally into the gill lamella, between two adjacent secondary gill lamellae and the marginal hooklets assist by superficially penetrating, holding and lifting epithelial tissue in the proximal region of the secondary gill lamella. The attachment of C. philander resulted in compression, rupturing of the interlamellar epithelium, change in the organization of epithelial cells in both primary and secondary gill lamella, displacement of the extracellular cartilaginous matrix, occasional rupturing of blood vessels and erythrocytes and some cells becoming ill‐defined. At the site of attachment, the host response comprises of hyperplasia, increase in the number of mucous cells and infiltration with neutrophils. It was concluded that the effect of C. philander is mild in natural conditions.
Hallmarks of postoperative liver regeneration: An updated insight on the regulatory mechanisms
Authors: Shi Ji‐Hua , Line Pål‐Dag 
Published: November 2019

AbstractPerformance and advances in liver surgery makes remarkable progress of the understanding of liver regeneration. Liver regeneration after liver resection has been widely researched, and the underlying mechanism mostly concerns proliferation of hepatocytes and the influence by inflammation through activation of Kupffer cells and the other parenchymal cells, the second regenerative pathway by hepatic progenitor cells (HPCs), inducing angiogenesis, remodeling of a extracellular matrix (ECM), and termination mechanisms. New clinical surgeries and the updated multiomics analysis are exploiting the remarkable progress, especially in immune regulation and metabolic process of two emerging hallmarks. This review briefly represents a systemic outline of eight hallmarks, including hepatocyte proliferation, contribution of hepatic progenitor cells, inducing angiogenesis, reprogramming of the extracellular matrix, apoptosis and termination of proliferation, inflammation, immune and metabolic regulation, which are set as organizing characteristics of postoperative liver regeneration and future directions of refining treatment targets.
Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice
Authors: Teixeira Pryscila D. S. , Wasinski Frederick , Lima Leandro B. , Frazão Renata , Bittencourt Jackson C. , Donato Jose 
Published: November 2019

AbstractNeurones expressing the melanin‐concentrating hormone (MCH) can be found in the medial preoptic area (mPOA) and ventral aspects of the periventricular preoptic nucleus of rats by mid‐to‐late lactation and this expression disappears after weaning. The transitory expression of MCH in the preoptic area suggests a role for these neurones in the control of the end of lactation. However, the neurochemical identity of mPOA MCH neurones and the regulatory factors that control the transient MCH expression remain largely unknown, especially in the mouse. In the present study, we showed that mice also present the transitory expression of MCH in the mPOA at late lactation. mPOA MCH cells did not colocalise significantly with markers of GABAergic (VGAT), glutamatergic (VGLUT2 and VGLUT3) or dopaminergic (tyrosine hydroxylase) neurones. mPOA MCH cells also did not express Kiss1 or oxytocin. By contrast, approximately 70% and 90% of mPOA MCH neurones colocalised with oestrogen receptor α and prolactin‐induced phosphorylated signal transducer and activator of transcription 5 (STAT5), respectively. Finally, we demonstrated that the number of MCH neurones in the mPOA is significantly higher in females during the first lactation, compared to mice on the second lactation or pregnant mice during the first lactation or brain‐specific STAT5 knockout mice during the first lactation. In summary, our findings indicate that MCH neurones in the mPOA of lactating mice are sensitive to oestrogens and prolactin. Thus, mPOA MCH expression is possibly influenced by hormonal variations. Furthermore, the STAT5 signalling pathway is likely involved in the regulation of MCH expression in the mPOA of lactating mice.
Dairy cow reproduction under the influence of heat stress
Authors: Sammad Abdul , Umer Saqib , Shi Rui , Zhu Huabin , Zhao Xueming , Wang Yachun 
Published: November 2019

AbstractDairy farming is vulnerable to global warming and climate change. Improving and maintaining conception rates (CRs) have a paramount importance for the profitability of any dairy enterprise. There is an antagonistic relationship between fertility and milk yield, and intensive selection for milk yield has severely deteriorated reproductive efficiency. Irrespective of geography and husbandry, modern dairy cows experience heat stress (HS) effects leading to fertility declines, but it worsens in tropical climates. The threshold of HS experience among modern dairy cow has lowered, leading to decreased thermal comfort zone. Studies show that this threshold is lower for fertility than for lactation. HS abatement and robustness response to lactation yield lead to negative energy balance, and cow's reproductive requirements remain unfulfilled. The adverse effects of HS commence from developing oocyte throughout later stages and its fertilization competence; the oestrus cycle and oestrus behaviour; the embryo development and implantation; on uterine environment; and even extend towards foetal calf. Even cows can become acyclic under the influence of HS. These harmful effects of HS arise due to hyperthermia, oxidative stress and physiological modifications in the body of dairy cows. Proper assessment of HS and efficient cooling of dairy animals irrespective of their stage of life at farm is the immediate strategy to reduce fertility declines. Other long‐ and short‐term mitigation strategies to reduce fertility declines during HS include feeding care, reducing disease and mastitis rates, using semen from cooled bulls, timed artificial inseminations (AI), allied hormonal interventions and use of embryo transfer technology. Ultimate long‐term solution should be well‐planned breeding for fertility improvement and HS tolerance.
Presentation, treatment and outcome of long‐bone fractures in pet rabbits (Oryctolagus cuniculus)
Authors: Garcia‐Pertierra S. , Ryan J. , Richardson J. , Koterwas B. , Keeble E. , Eatwell K. , Clements D. N. 
Published: November 2019

ObjectivesTo describe the incidence, aetiology, characteristics, assessment, management and outcome of long‐bone fractures in rabbits presenting to a single institution.Materials and MethodsMedical records of pet rabbits diagnosed with long‐bone fractures over a 12‐year period were analysed. Patient signalment, fracture aetiology, fracture location, fracture description, time from fracture occurrence to veterinary presentation, fixation method, postoperative complications, clinical outcome and follow‐up were recorded.ResultsTwenty‐eight pet rabbits that sustained 30 fractures were included in the study [femoral (n=12), tibial (n=6), metacarpal/metatarsal/phalangeal (n=5), radial and ulnar (n=4) and tarsal (n=3)]. Twenty‐one (75%) of the rabbits were less than 2 years of age, including seven (25%) under 6 months of age. Twenty‐five fractures had no identifiable cause and five were traumatic. Only one fracture was open. Surgical stabilisation was performed in 22 fractures, four were non‐surgically managed, two had the affected limb amputated, one underwent digital amputation and one was euthanased. Postoperative complications occurred in nine fractures [major (n=6), minor (n=3)]. The frequency of complications or attainment of a functional recovery was not notably different between the different methods of fixation. Overall, 24 rabbits recovered, two were euthanased and four underwent limb amputation.Clinical SignificanceFractures in rabbits typically occur in young animals and they usually lack an obvious aetiology. The majority of the rabbits treated achieved a functional recovery, although the postoperative complication rate was high in fractures treated surgically (41%).
Association between sleep quality and physical activity according to gender and shift work
Authors: Park Hwanjin , Suh Byungseong 
Published: November 2019

AbstractShift work directly causes circadian disruption and reduces sleep quality. Physical activity is also associated with sleep quality. However, no study has reported the relationship between a specific level of physical activity and sleep quality. This study aimed to investigate the relationship between sleep quality and the amount of physical activity by stratifying subjects into gender and shift‐work subgroups. Among those who participated in the Kangbuk Samsung Health Study in 2016–2017, data from 185,958 full‐time workers were analysed. We evaluated their physical activity by metabolic equivalents (METs‐min/week), sleep quality and shift work. A chi‐squared test, a t test and logistic regression analysis were performed. An increase in sleep quality was found for the group with physical activity of 600–9,000 METs‐min/week compared to that in the sedentary group among all subjects. In female day workers, the sleep quality of the group with 600–6,000 METs‐min/week was significantly higher (odds ratio [OR], 0.760; 95% confidence interval [CI], 0.673–857) than that in the sedentary group. In male day workers, sleep quality increased when physical activity was increased up to 6,000–9,000 METs‐min/week (OR, 0.760; 95% CI, 0.673–857). In female shift workers, there was no significant difference in sleep quality according to physical activity level. In male shift workers, sleep quality was better in the group with physical activity of 1,800–3,000 METs‐min/week (OR, 0.826; 95% CI, 0.692–0.986) or 3,000–6,000 METs‐min/week (OR, 0.771; 95% CI, 0.642–0.926). Optimal physical activity is good for sleep quality. The sleep quality of females is significantly worse than that of males in both day and shift workers.
The implications of labour unions in the presence of a merger
Authors: Cao Jiyun , Mukherjee Arijit , Sinha Uday Bhanu 
Published: November 2019

AbstractIt is usually believed that the presence of labour unions is detrimental for the consumers since it raises wages. We show that this view may not be true if we endogenize the impacts of labour unions on firms’ corporate strategies such as merger and acquisition. The presence of labour unions may benefit the consumers by deterring merger.
The gap between what patients know and desire to learn about their cardiac implantable electronic devices
Authors: Patel Divyang , Hu Peter , Hilow Henry , Lambert Cameron T. , Moufawad Michelle , Poe Stacy , Hussein Ayman A. , Baranowski Bryan , Bhargava Mandeep , Rickard John W. , Cantillon Daniel J. , Saliba Walid , Wilkoff Bruce L. , Wazni Oussama , Tarakji Khaldoun G. 
Published: November 2019

AbstractBackgroundAdvancement of digital technology now allows patients to have access to data from their cardiac implantable electronic devices (CIEDs). However, patients’ understanding regarding CIED data and perceived personal usability remain unclear. The present study is a prospective survey to examine patients’ understanding of their CIEDs and their perception of what is important.MethodsWe screened 400 patients between July and December 2018 who presented to our outpatient clinic for a CIED interrogation. Patients received a one‐page questionnaire asking baseline demographics, their perception about their own knowledge about their device, and multiple‐choice questions in seven basic categories: type of CIED, original indication, functionality, manufacturer, number of active leads, estimated battery life, and number of shocks received. We compared these answers to their interrogation reports to assess accuracy. We also asked participants what they would like to be aware of regarding their CIED.ResultsFrom this cohort, 344 of 400 (86%) (62.9 ± 12.8 years and 64 % males) agreed to take the survey and were included in the analysis. At baseline, 63.2% agreed or strongly agreed that they were knowledgeable about their devices. The overwhelming majority of patients demonstrated CIED knowledge deficits in at least one content area (n = 294, 86%), or more than two content areas (n = 176, 51%). Patients agreed or strongly agreed that they had a desire to have information regarding each of the following: battery life (84%), activity level (79%), heart rate trend (75%), and ventricular arrhythmias (74%).ConclusionThere is a large discrepancy in patients’ level of knowledge regarding their CIEDs and their wish to know more details. Future technologies should satisfy providers’ goals to educate their patients with basic information and fulfill patients’ desire to obtain more data from their CIEDs.
Explaining collaboration in consensual and conflictual governance networks
Authors: Gronow Antti , Wagner Paul , Ylä‐Anttila Tuomas 
Published: November 2019

AbstractThe conditions under which policy beliefs and influential actors shape collaborative behaviour in governance networks are not well understood. This article applies exponential random graph models to network data from Finland and Sweden to investigate how beliefs, reputational power and the role of public authorities structure collaboration ties in the two countries’ climate change governance networks. Results show that only in Finland's conflictual climate policy domain do actors collaborate with those with similar beliefs and with reputational power, while only in Sweden's consensual climate policy domain do public authorities play central impartial coordinating roles. These results indicate that conflict is present in a governance network when beliefs and reputational power determine collaboration and that it is absent when public authorities occupy central roles. They also suggest that relative success in climate policy action is likely to occur when public authorities take on network manager roles.