bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 4-gene signature from histologically normal surgical margins predicts local recurrence in patients with oral carcinoma: clinical validation
Authors: Reis Patricia P. , Tokar Tomas , Goswami Rashmi S. , Xuan Yali , Sukhai Mahadeo , Seneda Ana Laura , Móz Luis E. S. , Perez-Ordonez Bayardo , Simpson Colleen , Goldstein David , Brown Dale , Gilbert Ralph , Gullane Patrick , Irish Jonathan , Jurisica Igor , Kamel-Reid Suzanne 
Published: February 2020

AbstractPrognostic biomarkers for recurrence of Oral Squamous Cell Carcinoma (OSCC) are urgently needed. We aimed to independently validate a 4-gene expression signature (MMP1, COL4A1, P4HA2, THBS2) predictive of OSCC recurrence risk. Gene expression was measured using Nanostring nCounter® in 245 histologically normal surgical resection margins from 62 patients. Association between risk scores for individual patients and recurrence was assessed by Kaplan-Meier analysis. Signature performance was quantified by concordance index (CI), hazard ratio (HR) and the area under receiver operating characteristics (AUC). Risk scores for recurrence were significantly higher than recurrence-free patients (p = 9.58e-7, Welch’s t-test). A solid performance of the 4-gene signature was determined: CI = 0.64, HR = 3.38 (p = 1.4E-4; log-rank test), AUC = 0.71. We showed that three margins per patient are sufficient to preserve predictive performance (CI = 0.65; HR = 2.92; p = 2.94e-3; AUC = 0.71). Association between the predicted risk scores and recurrence was assessed and showed HR = 2.44 (p = 9.6E-3; log-rank test, N = 62). Signature performance analysis was repeated using an optimized threshold (70th percentile of risks), resulting in HR = 3.38 (p = 1.4E-4; log-rank test, N = 62). The 4-gene signature was validated as predictive of recurrence risk in an independent cohort of patients with resected OSCC and histologically negative margins, and is potentially applicable for clinical decision making on adjuvant treatment and disease monitoring.
Reference Interval Estimation from Mixed Distributions using Truncation Points and the Kolmogorov-Smirnov Distance (kosmic)
Authors: Zierk Jakob , Arzideh Farhad , Kapsner Lorenz A. , Prokosch Hans-Ulrich , Metzler Markus , Rauh Manfred 
Published: February 2020

AbstractAppropriate reference intervals are essential when using laboratory test results to guide medical decisions. Conventional approaches for the establishment of reference intervals rely on large samples from healthy and homogenous reference populations. However, this approach is associated with substantial financial and logistic challenges, subject to ethical restrictions in children, and limited in older individuals due to the high prevalence of chronic morbidities and medication. We implemented an indirect method for reference interval estimation, which uses mixed physiological and abnormal test results from clinical information systems, to overcome these restrictions. The algorithm minimizes the difference between an estimated parametrical distribution and a truncated part of the observed distribution, specifically, the Kolmogorov-Smirnov-distance between a hypothetical Gaussian distribution and the observed distribution of test results after Box-Cox-transformation. Simulations of common laboratory tests with increasing proportions of abnormal test results show reliable reference interval estimations even in challenging simulation scenarios, when <20% test results are abnormal. Additionally, reference intervals generated using samples from a university hospital’s laboratory information system, with a gradually increasing proportion of abnormal test results remained stable, even if samples from units with a substantial prevalence of pathologies were included. A high-performance open-source C++ implementation is available athttps://gitlab.miracum.org/kosmic.
Inflammatory cell infiltration in left atrial appendageal tissues of patients with atrial fibrillation and sinus rhythm
Authors: Hohmann Christopher , Pfister Roman , Mollenhauer Martin , Adler Christoph , Kozlowski Jolanta , Wodarz Andreas , Drebber Uta , Wippermann Jens , Michels Guido 
Published: February 2020

AbstractAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and is known to be associated with significant morbidity and mortality. Previous studies suggested a link between inflammation and AF by findings of increased inflammatory markers in AF patients. However, it has not been finally clarified whether inflammation is a systemic or a local phenomenon reflecting an active inflammatory process in the heart. To address this subject, human left atrial appendage tissues were obtained from 10 patients who underwent cardiac surgery and subjected to immunohistochemical analysis. The number of inflammatory CD3-positive T cells significantly increased from patients with sinus rhythm to paroxysmal AF and persistent AF, respectively. Interestingly, in patients with persistent AF, these cells were frequently arranged in small clusters. Subsequently, the number of inflammatory CD3-positive T cells decreased and was significantly lower in patients with permanent AF than in patients with persistent AF. Inflammatory CD20-positive B cells could only be detected very occasionally in all AF subgroups and were not locatable in patients with SR. Hence, our data emphasize the potential prominent role of the cellular component of the immune system in the development and perpetuation of AF.
Patient-Reported Outcomes and Evidence-Based Practice in Speech-Language Pathology
Authors: Cohen Matthew L. , Hula William D. 
Published: February 2020

Purpose
The patient's perspective of their health is a core component of evidence-based practice (EBP) and person-centered care. Patient-reported outcomes (PROs), captured with PRO measures (PROMs), are the main way of formally soliciting and measuring the patient's perspective. Currently, however, PROs play a relatively small role in mainstream speech-language pathology practice. The purpose of this article is to raise important questions about how PROs could be applied to EBP in speech-language pathology for individuals with communication disorders and to propose preliminary approaches to address some of these questions.

Method
Based on a narrative review of the literature, this article introduces relevant terminology and broadly describes PRO applications in other health care fields. The article also raises questions related to PRO-informed clinical practice in speech-language pathology. To address some of these questions, the article explores previous research to provide suggestions for clinical administration, interpretation, and future research.

Conclusion
More routine measurement of subjective health constructs via PROMs—for example, constructs such as effort, participation, self-efficacy, and psychosocial functioning—may improve EBP. More routine use of PROMs could significantly expand the information that is available to clinicians about individual clients and add to the evidence base for the profession of speech-language pathology. However, careful consideration and more research are needed on how to capture and interpret PROs from individuals with cognitive and language disorders.
Design of coupled inductors using split winding scheme for bridgeless SEPIC
Authors: Prabhu Pavana , Urundady Vinatha 
Published: February 2020

A bridgeless single‐ended primary inductance converter (SEPIC) is a highly preferred single‐stage front‐end AC–DC converter for applications requiring a wide variation of DC voltage because it also gives improved performance in terms of the quality of supply current. This study presents the design of coupled inductors for the bridgeless SEPIC using the split winding scheme. With coupling incorporated the required value of self‐inductances of the input and output inductors for the same performance is reduced. Also, they can be wound on the same core, thereby resulting in a reduction in size. The conventional method of tuning the coupling coefficient by adjusting the air‐gap is tedious. A split winding scheme for the distribution of windings over three limbs of E‐core for obtaining the desired coupling coefficient is presented. The split winding scheme for the design of coupled inductors for bridgeless SEPIC converter rated for 500 W, 20 kHz is illustrated. The effect of coupling on the volume, weight, cost, and efficiency of the converter is compared with the conventional SEPIC converter without coupling for a similar performance. The performance of the proposed converter is evaluated using MATLAB/Simulink simulation and experimental results with a laboratory prototype rated for 500 W.
High-resolution spectroscopy and spectropolarimetry of the total lunar eclipse January 2019
Authors: Strassmeier K. G. , Ilyin I. , Keles E. , Mallonn M. , Järvinen A. , Weber M. , Mackebrandt F. , Hill J. M. 
Published: February 2020

Context. Observations of the Earthshine off the Moon allow for the unique opportunity to measure the large-scale Earth atmosphere. Another opportunity is realized during a total lunar eclipse which, if seen from the Moon, is like a transit of the Earth in front of the Sun.
Aims. We thus aim at transmission spectroscopy of an Earth transit by tracing the solar spectrum during the total lunar eclipse of January 21, 2019.
Methods. Time series spectra of the Tycho crater were taken with the Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope in its polarimetric mode in Stokes IQUV at a spectral resolution of 130 000 (0.06 Å). In particular, the spectra cover the red parts of the optical spectrum between 7419–9067 Å. The spectrograph’s exposure meter was used to obtain a light curve of the lunar eclipse.
Results. The brightness of the Moon dimmed by 10.m75 during umbral eclipse. We found both branches of the O2 A-band almost completely saturated as well as a strong increase of H2O absorption during totality. A pseudo O2 emission feature remained at a wavelength of 7618 Å, but it is actually only a residual from different P-branch and R-branch absorptions. It nevertheless traces the eclipse. The deep penumbral spectra show significant excess absorption from the Na I 5890-Å doublet, the Ca II infrared triplet around 8600 Å, and the K I line at 7699 Å in addition to several hyper-fine-structure lines of Mn I and even from Ba II. The detections of the latter two elements are likely due to an untypical solar center-to-limb effect rather than Earth’s atmosphere. The absorption in Ca II and K I remained visible throughout umbral eclipse. Our radial velocities trace a wavelength dependent Rossiter-McLaughlin effect of the Earth eclipsing the Sun as seen from the Tycho crater and thereby confirm earlier observations. A small continuum polarization of the O2 A-band of 0.12% during umbral eclipse was detected at 6.3σ. No line polarization of the O2 A-band, or any other spectral-line feature, is detected outside nor inside eclipse. It places an upper limit of ≈0.2% on the degree of line polarization during transmission through Earth’s atmosphere and magnetosphere.
Forbidden atomic carbon, nitrogen, and oxygen emission lines in the water-poor comet C/2016 R2 (Pan-STARRS)
Authors: Raghuram S. , Hutsemékers D. , Opitom C. , Jehin E. , Bhardwaj A. , Manfroid J. 
Published: February 2020

Context.The N2and CO-rich and water-depleted comet C/2016 R2 (Pan-STARRS) – hereafter “C/2016 R2” – is a unique comet for detailed spectroscopic analysis.Aims.We aim to explore the associated photochemistry of parent species, which produces different metastable states and forbidden emissions, in this cometary coma of peculiar composition.Methods.We reanalyzed the high-resolution spectra of comet C/2016 R2 obtained in February 2018 using the UVES spectrograph of the European Southern Observatory Very Large Telescope. Various forbidden atomic emission lines of [CI], [NI], and [OI] were observed in the optical spectrum of this comet when it was at 2.8 au from the Sun. The observed forbidden emission intensity ratios are studied in the framework of a couple-chemistry emission model.Results.The model calculations show that CO2is the major source of both atomic oxygen green and red doublet emissions in the coma of C/2016 R2 (while for most comets it is generally H2O), whereas, CO and N2govern the atomic carbon and nitrogen emissions, respectively. Our modeled oxygen green-to-red-doublet and carbon-to-nitrogen emission ratios are higher by a factor of three than what is found from observations. These discrepancies could be due to uncertainties associated with photon cross sections or unknown production and/or loss sources. Our modeled oxygen green-to-red-doublet emission ratio is close to what is seen in observations when we consider an O2abundance with a production rate of 30% relative to the CO production rate. We constrained the mean photodissociation yield of CO, producing C(1S) at about 1%, a quantity which has not been measured in the laboratory. The collisional quenching is not a significant loss process for N(2D) though its radiative lifetime is significant (~10 h). Hence, the observed [NI] doublet-emission ratio ([NI] 5198/5200) of 1.22, which is smaller than the terrestrial measurement by a factor 1.4, is mainly due to the characteristic radiative decay of N(2D).
Chronische Pankreatitis – ein Update aus Sicht der Chirurgie
Authors: Belyaev Orlin , Uhl Waldemar 
Published: February 2020

ZusammenfassungDiese Übersichtsarbeit präsentiert den aktuellen evidenzbasierten Wissensstand über chronische Pankreatitis aus chirurgischer Sicht. Eine praxisorientierte Zusammenfassung der therapeutischen Strategie wird entsprechend den gültigen Leitlinien unter Berücksichtigung der neuesten Erkenntnisse aus der Literatur dargestellt.
The first elite sport training camp in France: Manitot (1912–1924)
Authors: Loudcher Jean‐François , Fabian Thomas 
Published: February 2020

AbstractOn the eve of the First World War, a wealthy director of a company, Antoine‐Lucien Boyer, has created at Manitot, a small village close to Paris on the riverside of the Seine opposite to Giverny, the first camp of coaching for athletes. Famous boxers like Billy Papke, Georges Carpentier, Eugène Criqui, and Bernard or runners like Jean Bouin have spent a while to prepare their competitions. Taking the opportunity of being at the countryside, these athletes did angling, rowing, and hunting in parallel to their specific sport preparation.Using different sources like newspapers (L'Auto, L’écho des sports), but also books and archives (public and privates), we aim at relating the history of this first sport camp of coaching and will try to understand the reasons of the landowner for launching this experience. Furthermore, we will review the methods of training and highlight a specifically French approach, based on an eclectic training method determined by health more than by performance.
Valley polarization in monolayer CrX2 (X = S, Se) with magnetically doping and proximity coupling
Authors: Lei Chengan , Ma Yandong , Zhang Ting , Xu Xilong , Huang Baibiao , Dai Ying 
Published: February 2020

Abstract
Manipulating the valley degree of freedom as an information carrier has been a focused topic for both fundamental and applied research. Here, using first-principles calculations, we report the identification of monolayer CrX2 (X = S, Se) as a novel two-dimensional valleytronic crystal. It shows large valley spin splitting in the valence band, attractive for the integration of valleytronics and spintronics. More importantly, through proximity coupling with monolayer CrCl3, the valley polarization in monolayer CrX2 is achieved, which can be further engineered by stacking patterns. Also, the valley polarization in monolayer CrX2 can be obtained via magnetically doping V and Mn. Specially for V-doped monolayer CrSe2, there are no impurity states in the band gap, beneficial for its practical applications. Our works thus provide not only exceptional two-dimensional valleytronic crystals but also promising ways for realizing valley polarizations in them.
Wuluh starfruit (Averrhoa bilimbi linn.) leaves extract as green corrosion inhibitor in reinforced steel
Authors: Elfidiah  , Kharismadewi D , Yuliwati E 
Published: February 2020

Abstract
A utilization of organic inhibitors to reduce corrosion rate in metals has been widely studied compared to inorganic inhibitors because of its environmentally friendly property. In this study, the extract of Wuluh starfruit leaves (Averrhoa Bilimbi Linn.), which is contains tannins and flavonoid compounds, was used as an inhibitor to inhibit the corrosion rate in reinforced steel. The objective of this study was to analyse the effect and the efficiency of volume inhibitor variation in 3% of NaCl corrosive medium to the corrosion rate of reinforced steel. The method used is based on the losing weight, where the sample was immersed in corrosive medium mixed with an inhibitor. The study results shown that the extract of Wuluh starfruit leaves was able to inhibit the corrosion rate as 0.0004 cm/yr at the optimum inhibitor volume of 16 mL with the efficiency of 99.7%
Characterization of pyroligneous acid produced from microwave-assisted treatment of palm kernel shell
Authors: Safazliana Raja Sulong Raja , Elyanie Zulkifli Seri , Hasham Rosnani , Akmar Zakaria Zainul 
Published: February 2020

Abstract
Palm oil plantation is one of the largest cultivation in Malaysia. The massive production of palm oil has abandoned huge palm oil biomass such as palm kernel shell that has become increasingly threatening environmental issue. Conversion of biomass through microwave pyrolysis has become one of the solutions to manage the abundance of biomass. Therefore, the aim of this study is to utilize the palm kernel shell for the production of pyroligneous acid (PA) by using microwave-assisted pyrolysis which would then be evaluated for its total phenolic content and scavenging DPPH free radicals. Pyroligneous acid of palm kernel shell will be produced from the condensation of smoke generated during pyrolysis process. From this study, the TPC observed was 49.96 mg GAE/g, whereas for the IC50, DPPH value obtained was, 66.19 µg/mL. Pyroligneous acid produced during the pyrolysis process has the potential to apply in various applications and could serve as an alternative eco-friendly source of natural antioxidant.
Modification of carboxymethyl cellulose from water hyacinth (Eichornia crassipes) using the succinic acid crosslinking method
Authors: Putri R D A , Bintang C A , Pangestu D B , Handayani P A 
Published: February 2020

Abstract
CMC (Carboxymethyl Cellulose) is an additional ingredient that is often used in the food and beverage industry. This causes the need for CMC is quite high in Indonesia. Data from the Badan Pusat Statistik shows that Indonesia still imported 4435.26 tons of CMC in 2018. In fact, cellulose as a raw material for making CMC can be easily found in nature. One of the plants which is known to have high cellulose content is water hyacinth, which can reach 66.87%. Besides having high cellulose content, water hyacinth is also often regarded as a weed that grows very fast, so it must be utilized so as not to damage the environment. In CMC synthesis isopropyl alcohol is used as a solvent in the ratio of 1:2, 1:4 and 1:6. The CMC yield can also be improved by crosslinking using succinic acid. The variation of succinic acid ratio is 1:1, 2:1 and 3:1 and the yield of CMC reaches 198%, 140.66% and 122.66%, respectively. FTIR test shows CMC without crosslinking has a group that is identical to CMC Cap KoepoeKoepoe. While in crosslinking CMC new groups are formed which occur due to the addition of succinic acid. Organoleptic test results show results similar to CMC Cap Koepoe-Koepeoe. Meanwhile the pH test at CMC variable 2:1 and 3:1 has pH number 6, fulfilling FI/JECFA/SNI standard.
Brachiaria mutica dyes powder for textile application: dyeing quality of cotton fabrics
Authors: Kusumastuti Adhi , Selvia Fardhyanti Dewi , Anis Samsudin 
Published: February 2020

Abstract
To minimise water pollution as well as to improve the economic value of some unutilised natural resources, application of natural dyes have been widely encouraged this past decade. Natural dyes considered to be effective in minimising the use of chemical agents which in turn overcome pollution problems. Despite the advantages of natural dyes, few problems are also encountered. It is therefore production of natural dyes powder becomes another concern. In this article, application of Brachiaria mutica as natural dyes powder for textile dyeing was discussed in terms of colour darkness, colour fastness, and colour difference. Experiment was carried out by observing dyeing process using 4 types of mordants, i.e. lime, alum, limestone, and ferrous sulphate. The colour darkness of cotton fabric was in the order of system with ferrous sulphate > limestone > alum > lime juice. The system with alum, limestone, and ferrous sulphate generated colour of green, while system with lime juice resulted in yellowish green colour. In term of colour fastness to washing, the quality was in the order of system with ferrous sulphate > limestone > alum > lime juice.
Monitoring system of land cover quality using segmentation and content base image retrieval methods
Authors: Handoko Dwi , Irianto Suhendro Y. , Karnila Sri 
Published: February 2020

Abstract
This paper tries to explore level and accuracy Content Based Image Retrieval method on Landsat imaginary. The images include an areal photography and land satellite photoraphy or Landsat which widely used and recognize for spatial information analysis. The analysis uses mapping of situation or state of earth’s surface, particularly the land surface. Landsat can be used to create topographic map, determining of attitude or height model of a certain place in the earth. Aerial photographs are used to detect changes of earth surface, in this work the changes by using Content Based Image retrieval or CBIR. The accuracy changes measurement calculates using precision and recall parameters. In this paper, Landsat images also used to detect the appear and dis appear of vegetation and other objects on the earth. More than 100 Landsat images used in this work, and around 15 images were use d as queries. The results show that accuracy of image retrieval is a quite good, which more than 75 %.
The use of input capture method to increase torque on switched reluctance motor
Authors: Nur Saiful Hakim Maulana , Riyadi Slamet 
Published: February 2020

Abstract
Electric drives are used in many industrial applications, one of these is Switched Reluctance Motor (SRM). Such a motor is used because it has a simple construction, efficient, and low cost. Three-phase switched reluctance motor commonly has some stators and rotors, which is implemented on the asymmetric converter. To operate the Switched Reluctance Motor, an optical encoder or hall-effect sensor will affect motor performance. To improve motor performance, the input capture method is used. Such a method can give accurate commutation angel so the excitation can be given in proper angel and increases torque on SRM. To verify the proposed method, analysis, and experimental tests were done.
Comparison of Different Rule Base Matrix in Fuzzy Logic Controller
Authors: Afrian Verdy , Riyadi Slamet 
Published: February 2020

Abstract
The development of power electronics technology has been widely applied in various fields. Converters have been widely used in renewable energy and several industrial applications. Many control that used to operate the converter, one of these is Fuzzy Logic Controller (FLC). FLC is used because it has advantages such as fast response and good performance. FLC is a rule-based control system, so the basic rules are made to operate this system by input processing. Fuzzy variable 3x3 matrix rule base is less responsive in achieving steady state conditions. Therefore, a 5x5 matrix rule base fuzzy variable is modified, so that it gets smoother response and faster system to achieve steady state. In this paper, the response of the output voltage to changes in the fuzzy variable 3x3 matrix rule base will be compared to the 5x5 matrix rule base.