bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Highly Active Heterostructured Al2TiO5/TiO2 Photocatalyst in a Neutral Medium
Authors: Trung Nguyen D. , Tri Nguyen , Phuong Phan H. , Anh Ha C. 
Published: December 2020

In this work, heterostructured catalyst Al2TiO5/TiO2 (ATO/Ti) was synthesized by a two-step method: low-temperature sol-gel process along with hydrothermal treatment in a neutral medium. Characteristics of the fabricated catalyst were analyzed by various techniques including X-ray diffraction, Fourier transform infrared spectroscopy, Brunauer-Emmett-Teller adsorption, UV-Vis diffuse reflectance spectroscopy, energy-dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and the point of zero charges. The content of ATO strongly affected the activity of ATO/Ti catalysts for photocatalytic degradation of cinnamic acid (CA). The catalyst, in which 33% TiO2 was replaced by ATO (33ATO/Ti), exhibited the highest activity for the removal of CA. Compared with the bare titanium oxide synthesized in water (TiO2(w)) as well as Al2TiO5 (ATO), the hybrid 33ATO/Ti catalyst exhibited the enhanced photocatalytic activity in the CA degradation under ultraviolet light. The enhancement in the catalytic activity of ATO/Ti could be related to the increase of the specific surface area and the reduction of bandgap energy obtained from the hybridization of TiO2(w) and ATO. The factors as the catalyst dosage (

C

cat

), the airflow rate (

Q

air

), and the solution initial pH (pH) affected the CA removal efficiency were studied on 33ATO/Ti catalyst. The optimum condition for photodegradation efficiency of CA was found to be at

C

cat

=
0.75

g

L

−
1

,

Q

air

=
0.3

Lmi

n

−
1

, and

pH
=
3.8

. The highest 60-minute removal efficiency of CA reached 77.1% on 33ATO/Ti compared with 67.1% and 30.4% on TiO2(w) and on ATO, respectively. The recyclability of the 33ATO/Ti was also measured at the optimal parameters. The results showed that, compared with TiO2, the hybrid catalyst was easier to recover and reuse, and its activity decreased by 35% after 6 continuous cycles.
Triglyceride Can Predict the Discordance between QCT and DXA Screening for BMD in Old Female Patients
Authors: Xu Dongjiang , di Wang Ke , Yang Jianhong 
Published: December 2020

Summary. Bone mineral density (BMD) data and biochemical indexes of the elderly women in the cadre department were analyzed retrospectively to find out the relationship between the biochemical indexes and the different screening results between dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Purpose. This study is aimed at exploring which indicator can predict the discordance between DXA and QCT. Methods. 192 female patients who took BMD screening tests by QCT and DXA were recruited, and the biomarkers were analyzed to study the relationship between the biomarkers and the discordance of two BMD screening methods. Results. There are 42, 78, and 72 female patients in the normal, osteopenia, and osteoporosis groups defined by DXA and 6, 54, and 132 female patients in the corresponding group defined by QCT. DXA was less sensitive than QCT. Cholesterol (CHO) and triglyceride (TG) were all negatively correlated with the discordance between these two methods. When

TG
>
0.89

mmol/L, the QCT result would be the same as the DXA’s; otherwise, there should be discordance between QCT and DXA. Conclusions. Triglyceride can be used to predict the discordance between QCT and DXA, and clinicians can evaluate patients’ DXA results based on patient triglyceride or cholesterol results as a supplement to QCT results.
Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET
Authors: Garcia-Moure Marc , Gonzalez-Huarriz Marisol , Labiano Sara , Guruceaga Elizabeth , Bandres Eva , Zalacain Marta , Marrodan Lucia , de Andrea Carlos , Villalba Maria , Martinez-Velez Naiara , Laspidea Virginia , Puigdelloses Montse , Gallego Perez-Larraya Jaime , Iñigo-Marco Ignacio , Stripecke Renata , Chan Jennifer A. , Raabe Eric H. , Kool Marcel , Gomez-Manzano Candelaria , Fueyo Juan , Patiño-García Ana , Alonso Marta M. 
Published: December 2020

Abstract

Purpose:
Atypical teratoid/rhabdoid tumors (AT/RT) and central nervous system primitive neuroectodermal tumors (CNS-PNET) are pediatric brain tumors with poor survival and life-long negative side effects. Here, the aim was to characterize the efficacy and safety of the oncolytic adenovirus, Delta-24-RGD, which selectively replicates in and kills tumor cells.

Experimental Design:
Delta-24-RGD determinants for infection and replication were evaluated in patient expression datasets. Viral replication and cytotoxicity were assessed in vitro in a battery of CNS-PNET and AT/RT cell lines. In vivo, efficacy was determined in different orthotopic mouse models, including early and established tumor models, a disseminated AT/RT lesion model, and immunocompetent humanized mouse models (hCD34+-NSG-SGM3).

Results:
Delta-24-RGD infected and replicated efficiently in all the cell lines tested. In addition, the virus induced dose-dependent cytotoxicity [IC50 value below 1 plaque-forming unit (PFU)/cell] and the release of immunogenic markers. In vivo, a single intratumoral Delta-24-RGD injection (107 or 108 PFU) significantly increased survival and led to long-term survival in AT/RT and PNET models. Delta-24-RGD hindered the dissemination of AT/RTs and increased survival, leading to 70% of long-term survivors. Of relevance, viral administration to established tumor masses (30 days after engraftment) showed therapeutic benefit. In humanized immunocompetent models, Delta-24-RGD significantly extended the survival of mice bearing AT/RTs or PNETs (ranging from 11 to 27 days) and did not display any toxicity associated with inflammation. Immunophenotyping of Delta-24-RGD–treated tumors revealed increased CD8+ T-cell infiltration.

Conclusions:
Delta-24-RGD is a feasible therapeutic option for AT/RTs and CNS-PNETs. This work constitutes the basis for potential translation to the clinical setting.
Association Between Low Muscle Mass and Prognosis of Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention
Authors: Kim Chi‐Hoon , Rhee Tae‐Min , Park Kyung Woo , Soon Park Chan , Kang Jeehoon , Han Jung‐Kyu , Yang Han‐Mo , Kang Hyun‐Jae , Koo Bon‐Kwon , Kim Hyo‐Soo 
Published: December 2020

Background
Low muscle mass has been associated with poor prognosis in certain chronic diseases, but its clinical significance in patients with coronary artery disease is unclear. We assessed the clinical significance of 2 easily measured surrogate markers of low muscle mass: the ratio of serum creatinine to serum cystatin C (Scr/Scys), and the ratio of estimated glomerular filtration rate by Scys to Scr (eGFRcys/eGFRcr).

Methods and Results
Patients with coronary artery disease undergoing percutaneous coronary intervention were prospectively enrolled from a single tertiary center, and Scr and Scys levels were simultaneously measured at admission. Best cut‐off values for Scr/Scys and eGFRcys/eGFRcr to discriminate 3‐year mortality were determined; 1.0 for men and 0.8 for women in Scr/Scys, and 1.1 for men and 1.0 for women in eGFRcys/eGFRcr. The prognostic values on 3‐year mortality and the additive values of 2 markers on the predictive model were compared. In 1928 patients enrolled (mean age 65.2±9.9 years, 70.8% men), the risk of 3‐year mortality increased proportionally according to the decrease of the surrogate markers. Both Scr/Scys‐ and eGFRcys/eGFRcr‐based low muscle mass groups showed significantly higher risk of death, after adjusting for possible confounders. They also increased predictive power of the mortality prediction model. Low Scr/Scys values were associated with high mortality rate in patients who were ≥65 years, nonobese, male, had renal dysfunction at baseline, and presented with acute myocardial infarction.

Conclusions
Serum surrogate markers of muscle mass, Scr/Scys, and eGFRcys/eGFRcr may have clinical significance for detecting patients with coronary artery disease at high risk for long‐term mortality.
Association Between Frailty and Atrial Fibrillation in Older Adults: The Framingham Heart Study Offspring Cohort
Authors: Orkaby Ariela R. , Kornej Jelena , Lubitz Steven A. , McManus David D. , Travison Thomas G. , Sherer Jason A. , Trinquart Ludovic , Murabito Joanne M. , Benjamin Emelia J. , Preis Sarah R. 
Published: December 2020

Background
Frailty is associated bidirectionally with cardiovascular disease. However, the relations between frailty and atrial fibrillation (AF) have not been fully elucidated.

Methods and Results
Using the FHS (Framingham Heart Study) Offspring cohort, we sought to examine both the association between frailty (2005–2008) and incident AF through 2016 and the association between prevalent AF and frailty status (2011–2014). Frailty was defined using the Fried phenotype. Models adjusted for age, sex, and smoking. Cox proportional hazards models, adjusted for competing risk of death, assessed the association between prevalent frailty and incident AF. Logistic regression models assessed the association between prevalent AF and new‐onset frailty. For the incident AF analysis, we included 2053 participants (56% women; mean age, 69.7±6.9 years). By Fried criteria, 1018 (50%) were robust, 903 (44%) were prefrail, and 132 (6%) were frail. In total, 306 incident cases of AF occurred during an average 9.2 (SD, 3.1) follow‐up years. After adjustment, there was no statistically significant association between prevalent frailty status and incident AF (prefrail versus robust: hazard ratio [HR], 1.22 [95% CI, 0.95–1.55]; frail versus robust: HR, 0.92 [95% CI, 0.57–1.47]). At follow‐up, there were 111 new cases of frailty. After adjustment, there was no statistically significant association between prevalent AF and new‐onset frailty (odds ratio, 0.48 [95% CI, 0.17–1.36]).

Conclusions
Although a bidirectional association between frailty and cardiovascular disease has been suggested, we did not find evidence of an association between frailty and AF. Our findings may be limited by sample size and should be further explored in other populations.
Five‐Year Risk of Acute Myocardial Infarction After Acute Ischemic Stroke in Korea
Authors: Lee Keon‐Joo , Kim Seong‐Eun , Kim Jun Yup , Kang Jihoon , Kim Beom Joon , Han Moon‐Ku , Choi Kang‐Ho , Kim Joon‐Tae , Shin Dong‐Ick , Cha Jae‐Kwan , Kim Dae‐Hyun , Kim Dong‐Eog , Ryu Wi‐Sun , Park Jong‐Moo , Kang Kyusik , Kim Jae Guk , Lee Soo Joo , Oh Mi‐Sun , Yu Kyung‐Ho , Lee Byung‐Chul , Park Hong‐Kyun , Hong Keun‐Sik , Cho Yong‐Jin , Choi Jay Chol , Sohn Sung Il , Hong Jeong‐Ho , Park Moo‐Seok , Park Tai Hwan , Park Sang‐Soon , Lee Kyung Bok , Kwon Jee‐Hyun , Kim Wook‐Joo , Lee Jun , Lee Ji Sung , Lee Juneyoung , Gorelick Philip B. , Bae Hee‐Joon ,   the CRCS‐K Registry Investigators
Published: December 2020

Background
The long‐term incidence of acute myocardial infarction (AMI) in patients with acute ischemic stroke (AIS) has not been well defined in large cohort studies of various race‐ethnic groups.

Methods and Results
A prospective cohort of patients with AIS who were registered in a multicenter nationwide stroke registry (CRCS‐K [Clinical Research Collaboration for Stroke in Korea] registry) was followed up for the occurrence of AMI through a linkage with the National Health Insurance Service claims database. The 5‐year cumulative incidence and annual risk were estimated according to predefined demographic subgroups, stroke subtypes, a history of coronary heart disease (CHD), and known risk factors of CHD. A total of 11 720 patients with AIS were studied. The 5‐year cumulative incidence of AMI was 2.0%. The annual risk was highest in the first year after the index event (1.1%), followed by a much lower annual risk in the second to fifth years (between 0.16% and 0.27%). Among subgroups, annual risk in the first year was highest in those with a history of CHD (4.1%) compared with those without a history of CHD (0.8%). The small‐vessel occlusion subtype had a much lower incidence (0.8%) compared with large‐vessel occlusion (2.2%) or cardioembolism (2.4%) subtypes. In the multivariable analysis, history of CHD (hazard ratio, 2.84; 95% CI, 2.01–3.93) was the strongest independent predictor of AMI after AIS.

Conclusions
The incidence of AMI after AIS in South Korea was relatively low and unexpectedly highest during the first year after stroke. CHD was the most substantial risk factor for AMI after stroke and conferred an approximate 5‐fold greater risk.
The Pentecostal Antirevolution: Reflections from Angola
Authors: Blanes Ruy Llera , Zawiejska Natalia 
Published: December 2020

Abstract
This article discusses the so-called ‘revolutionary’ character of Evangelical and Pentecostal movements, as has been proposed in mainstream sociological and anthropological literature. Through a historical and ethnographic account of Evangelical and Pentecostal Christianity in Angola, we suggest that in this country Evangelicalism and Pentecostalism is defined by exclusionary tactics that render most churches compliant with the current political regime, and they in fact act as reactionary, conservative forces in contexts of social and political disruption. This in turn exposes a divergence in terms of political rhetoric and praxis among Evangelical and Pentecostal movements.
La contribution de Friedrich Wilhelm Zahn (1845—1904) à l'étude de l'inflammation
Authors: Benaroyo Lazare 
Published: December 2020

Avant d’être appelé à occuper la première chaire de pathologic à l'Universitc de Genève, Friedrich Wilhelm Zahn a publié en 1871 sa these de doctoral intitules: Zur Lehre von der Entzündung und Eiterung. Ce travail, rédigé sous la direction d’ Edwin Klebs, à Berne, démontre expërimentale merit que le prétendu Microsporon septicum (un champignon infectieux identifié par ce dernier) provoque une inflammation locale ainsi que Fapparition de foyers de suppuration secondaires, a distance. Cette étude confirme apparemment Fhypothèse de Klebs selon laquelle le Microsporon septicum, habituellement present dans les plates, est la cause d' une maladie infectieuse. La recherche de Zahn fait d’emblée Fob jet d’une critique, également adressée à Klebs : V identification du microorga-nisme, de rnëme que la demonstration de son action causale ne s ont pas concluan-tes. A Fissue du debat, il est admis qu’un microorganisme ne pent être la cause d'un état infectieux qu'aux deux conditions suivantes: il doit être considéré comme identifié selon la méthode de Koch, et la relation causale qui l'unit à la maladie infectieuse doit être spédfique. C’est ce que la thèse de Zahn n’est précisément pas parvenue a dérnontrer.
L’analyse du contenu de cette recherche ainsi que des critiques qu’elle a suscitées nous permet de mettre en lumière les divers arguments qui ont alimenté la controverse sur la cause de l'inflammation et de la suppuration ä l'aube de l'ère bactériologique.
“The Sixth Sense”: Towards a History of Muscular Sensation
Authors: Smith Roger 
Published: December 2020

This paper outlines the history of knowledge about the muscular sense and provides a bibliographic resource for further research. A range of different topics, questions and approaches have interrelated throughout this history, and the discussion clarifies this rather than presenting detailed research in any one area. P art I relates the origin of belief in a muscular sense to empiricist accounts of the contribution of the senses to knowledge from Locke, via the idéologues and other authors, to the second half of the nineteenth century. Analysis paid much attention to touch, first in the context of the theory of vision and then in its own right, which led to naming a distinct muscular sense. From 1800 to the present, there was much debate, the main lines of which this paper introduces, about the nature and function of what turned out to be a complex sense. A number of influential psycho-physiologists, notably Alexander Bain and Herbert Spencer, thought this sense the most primitive and primary of all, the origin of knowledge of world, causation and self as an active subject. Part II relates accounts of the muscular sense to the development of nervous physiology and of psychology.
In the decades before 1900, t he developing separation of philosophy, psychology and physiology as specialised disciplines divided up questions which earlier writers had discussed under the umbrella heading of muscular sensation. The term ‘kinaesthesia’ came in 1880 and ‘proprio-ception’ in 1906. There was, all the same, a lasting interest in the argument that touch and muscular sensation are intrinsic to the existence of embodied being in the way the other senses are not. In the wider culture – the arts, sport, the psychophysiology of labour and so on – there were many ways in which people expressed appreciation of the importance of what the anatomist Charles Bell had called ‘the sixth sense’.
Confronting Otherness through Theatre: On Directing The Merchant of Venice for Thai Audiences
Authors: Na-pombejra Dangkamon 
Published: December 2020

Abstract
This article analyzes on a new directorial approach to Venice Vanija (เวนิสวาณิช), a Thai version of William Shakespeare’s The Merchant of Venice (written 1596–99) and translated by King Rama vi (r. 1910–1925). It aimed to create a new space and new rules that would encourage Thai audiences to embrace new perspectives by watching the performance. The production was directed by the author in 2018 in the Department of Dramatic Arts in the Faculty of Arts at Chulalongkorn University.
The directing approach focused on the play’s famous line “all that glitters is not gold;” (Act ii, scene vii, line 65), and stressed how struggles between majorities and “the Other” are connected to identity conflicts that contrast with tensions with other people and conflicts within the whole community.
The above focus was elaborated by using alienation effects, including a grotesque modern fairytale-like look, a nearly all-female cast, a distinctive traverse stage and set design, effeminate costumes for male characters portrayed by actresses, and mixed acting techniques.
The director achieved his goals by concentrating on the message and the main conflicts in the play, transforming “aliens into the allies” through using good surprises and friendly attacks, and respecting every party.
Vertical Structure of the Beaufort Gyre Halocline and the Crucial Role of the Depth-Dependent Eddy Diffusivity
Authors: Kenigson Jessica S. , Gelderloos Renske , Manucharyan Georgy E. 
Published: December 2020

AbstractTheories of the Beaufort Gyre (BG) dynamics commonly represent the halocline as a single layer with a thickness depending on the Eulerian-mean and eddy-induced overturning. However, observations suggest that the isopycnal slope increases with depth, and a theory to explain this profile remains outstanding. Here we develop a multilayer model of the BG, including the Eulerian-mean velocity, mesoscale eddy activity, diapycnal mixing, and lateral boundary fluxes, and use it to investigate the dynamics within the Pacific Winter Water (PWW) layer. Using theoretical considerations, observational data, and idealized simulations, we demonstrate that the eddy overturning is critical in explaining the observed vertical structure. In the absence of the eddy overturning, the Ekman pumping and the relatively weak vertical mixing would displace isopycnals in a nearly parallel fashion, contrary to observations. This study finds that the observed increase of the isopycnal slope with depth in the climatological state of the gyre is consistent with a Gent–McWilliams eddy diffusivity coefficient that decreases by at least 10%–40% over the PWW layer. We further show that the depth-dependent eddy diffusivity profile can explain the relative magnitude of the correlated isopycnal depth and layer thickness fluctuations on interannual time scales. Our inference that the eddy overturning generates the isopycnal layer thickness gradients is consistent with the parameterization of eddies via a Gent–McWilliams scheme but not potential vorticity diffusion. This study implies that using a depth-independent eddy diffusivity, as is commonly done in low-resolution ocean models, may contribute to misrepresentation of the interior BG dynamics.
The Effect of Perianal Tramadol Infiltration on Postoperative Pain Following Hemorrhoidectomy
Authors: Hatami Maryam , Talebi Mohammad , Heiranizadeh Naimeh , Vaziribozorg Sedighe 
Published: December 2020

Introduction The present study was attempted to evaluate the effect of perianal infiltration of tramadol on postoperative pain in patients undergoing hemorrhoidectomy. Method This double-blind clinical trial study was carried out on 90 patients with grade 3 and 4 hemorrhoids undergoing hemorrhoidectomy. Patients were randomly assigned into 3 groups of control or bupivacaine or tramadol. Before the surgery, perianal infiltration of .25% bupivacaine or tramadol or normal saline was prescribed to each group, respectively. Data on pain severity (based on the visual analog scale (VAS), the duration of surgery, sedation score, pain at the first defecation, first request time for additional analgesia, nausea and vomiting, and analgesic intakes) were evaluated and analyzed. Results Duration of surgery was almost similar in all 3 groups ( P = .974). The results showed a significant difference in pain score between 3 groups ( P ≤.05) at all times after the surgery. In addition, the means of sedation scores ( P = .03), pain score at the first defecation ( P = .001), the time to first analgesic request ( P = .001), and ketorolac administration times ( P = .01) were significantly different between 3 groups. Finally, no complication was reported regarding postoperative nausea and vomiting. Conclusion Given the notable efficacy of tramadol in reducing pain after hemorrhoidectomy and its minor side effects, this medication is suggested as an effective topical anesthetic to decrease pain after hemorrhoidectomy.
A Canadian national survey of informal employed caregivers of older adults with and without dementia: Work and employee outcomes
Authors: Sadavoy Joel , Sajedinejad Sima , Duxbury Linda , Chiu Mary 
Published: December 2020

Background: The majority of family caregivers (CG) caring for older adults, many of whom have dementia, are employees concurrently contending with the work demands and the stress and conflicts of caregiving. Both employers and CG employees are challenged by the need to address this problem. Method: A cross-sectional Canadian survey was distributed nationally to working informal CGs of older adults in 2015 to 2016. It was designed to investigate the relative predictive roles of caregiving variables, job demands, balancing work and caregiving variables, and work-related factors on work and employee outcomes. Our sample was comprised of employees ( N = 1,839) who were concurrently providing informal care for an older adult with specific attention to those caring for care recipients (CR) with dementia. We employed hierarchical and ordinal multiple regression to examine CG and caregiving characteristics, family and job demands, and balancing job-caregiving variables as predictors of work-related outcomes including work engagement, employment/employee changes index, absenteeism, and intent-to-turnover. Results: After controlling for CGs’ age, sex, and family financial situation, we found dementia demands, job-caregiving conflict, effective manager, and organizational culture were significant predictors of five out of six work and employee outcomes. Role overload was significantly associated with four outcomes. Conclusion: To our knowledge, this is the first study of this size to explore the association of these predictive variables with work-related outcomes and to refine the understanding of the profile of employed CGs of older adults with dementia. Sustaining working CGs of older adults may require new ‘talent management’ approaches rather than simply increasing the number of benefits.