bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROFILE OF CRITICAL THINKING SKILLS OF STUDENTS IN CLASS VII SMP ON FRACTION ADDITION MATERIAL IN TERMS OF GENDER
Authors: Amelia Reski , Alfisyahra Alfisyahra , Idris Mustamin , Lefrida Rita 
Published: December 2024

This study aims to obtain an overview of the critical thinking skills of male and female students in class VII A SMPN 9 Palu on fraction addition material. This research aims to: 1) to obtain a description of the critical thinking ability of male students on the addition and subtraction of fractions 2) to obtain a description of the critical thinking ability of female students on the addition and subtraction of fractions. This type of research is descriptive using a qualitative approach. The subjects of this research were 2 students taken from 31 students of class VII A SMPN 9 Palu consisting of 1 male student with high mathematics ability and 1 female student with high mathematics ability. The results of this study showed that male and female subjects with high mathematics ability were able to fulfill the indicators of critical thinking ability by Facione (2015), namely: (1) can interpret the problem by identifying the information known and asked appropriately and able to interpret and understand the symbols contained in the problem, (2) connect between statements, questions and concepts by making mathematical modeling appropriately (3) determine and use the right strategy in the calculation process so as to find the right final solution, (4) able to draw conclusions from what is asked in the problem, and (5) have the awareness to re-examine the solution of the problem given by identifying errors in determining the strategy or in the calculation process and then being able to believe the answer. Penelitian ini bertujuan untuk memperoleh gambaran kemampuan berpikir kritis siswa laki-laki dan perempuan kelas VII A SMPN 9 Palu pada materi penjumlahan pecahan. Jenis penelitian ini adalah deskriptif dengan menggunakan pendekatan kualitatif. Subjek penelitian ini adalah 2 orang siswa yang diambil dariÂ 31 siswa kelas VII A SMPN 9 Palu yang terdiri dari 1 orang siswa laki-laki berkemampuan matematika tinggi dan 1 orang siswa perempuan berkemampuan matematika tinggi. Hasil penelitian ini menunjukkan bahwa subjek laki-laki dan perempuan berkemampuan matematika tinggi mampu memenuhi indikator kemampuan berpikir kritis oleh Facione (2015), yaitu : (1) dapat menginterpretasi masalah dengan mengidentifikasi informasi yang diketahui dan ditanyakan dengan tepat serta mampu memaknai dan memahami simbol yang terdapat di soal, (2) menghubungkan antara pernyataan, pertanyaan dan konsep-konsep dengan membuat pemodelan matematika dengan tepat (3) menentukan dan menggunakan strategi yang tepat dalam proses perhitungan sehingga mampu menemukan solusi akhir yang tepat, (4) mampu menarik kesimpulan dari apa yang ditanyakan pada soal, dan (5) memiliki kesadaran untuk memeriksa kembali penyelesaian soal yang diberikan dengan mengidentifikasi kesalahan dalam menentukan strategi maupun pada proses perhitungan serta kemudian mampu meyakini jawabannya.
„Psychoterapia Ocalałych z Holokaustu w Polsce po 30 latach”
Authors: Prot-Klinger Katarzyna , Szwajca Krzysztof 
Published: December 2024

W artykule Autorzy podsumowują zmiany, jakie zachodziły podczas ich 30-letniego doświadczenia psychoterapii ocalałych z Holokaustu. Program zainicjowany przez profesor Marię Orwid jest jedynym programem psychoterapeutycznym adresowanym do tej grupy w Polsce. W artykule opisano, jak badania dotyczące udziału Polaków w Zagładzie wpłynęły na świat wewnętrzny uczestników terapii grupowej. Autorzy stawiają hipotezę, że ocalali przez lata żyli w rzeczywistości zdysocjowanej – z jednej strony ich osobistym doświadczeniem był wojenny lęk przed Polakami, z drugiej − Polakom zawdzięczali przeżycie. Te dwie rzeczywistości pozostawały w oddzieleniu. Tak jak osoba po traumatycznym wydarzeniu może mieć poczucie dwóch rzeczywistości – jednej, w której doświadczyła urazu, i drugiej, w której to zdarzenie nie miało miejsca, tak ocalali nie łączyli tych doświadczeń.
Przedmiotem opisu jest specyficzna grupa – tych, którzy po wojnie pozostali w Polsce, co zwykle nie było ich samodzielną decyzją, ale też nie wyjechali w kolejnych falach migracyjnych, włącznie z ostatnią, po 1968 r. Musieli odszczepiać wiedzę dotyczącą Polaków-prześladowców, żeby móc żyć, zakładać rodziny i czuć się bezpiecznie. I nagle ta rzeczywistość, której nie dotykali w swoich wspomnieniach, stała się przedmiotem debaty publicznej. Zdaniem autorów, zewnętrzne uznanie dla tej części ich doświadczenia pełniło rolę leczniczą, umożliwiło mówienie o, do tej pory, nieobecnych wspomnieniach.
Podejście prowadzących terapię ocalałych zmieniało się w miarę trwania programu. W tym czasie ukazało się na całym świecie dużo prac dotyczących konsekwencji wydarzenia urazowego i psychoterapii traumy. W obszarze psychoanalizy dokonał się odwrót od myślenia w kategoriach wyparcia jako głównego mechanizmu obronnego, a na znaczeniu zyskały zapomniane teorie Ferencziego dotyczące dysocjacji. Zmiana akcentu z wyparcia na dysocjację prowadzi do zaakceptowaniu przez Autorów zmiennego i wielopoziomowego dostępu do doświadczenia, co dotyczy także omawianych w czasie psychoterapii doświadczeń ocalałych.
El Planteamiento Estructural Como Determinante Arquitectónico:La Nueva Galería Nacional De Berlín De Ludwig Mies Van Der Rohe
Authors: Barrera Peñafiel Luis Enrique , Guerra Galán Jaime Augusto 
Published: December 2024

Este artículo de investigación, a través del análisis de planos, imágenes y bibliografía, pretende determinar la influencia que el planteamiento y solución estructural ha tenido dentro del resultado arquitectónico de la nueva Galería Nacional de Berlín (diseño: 1962-1965, construcción: 1965-1968) diseñada por el arquitecto alemán Ludwig Mies van der Rohe (1886-1969), al definir las estrategias fundamentadas en la teoría estructural que determinan el resultado morfológico del proyecto. Por lo tanto, el análisis expondrá, de manera descriptiva, los conceptos estructurales evidentes en la obra, y que determinan el resultado formal y la organización funcional del edificio. Esto muestra la interacción que estos conceptos tienen en la manera de obtener soluciones proyectuales del arquitecto Mies van der Rohe.Palabras clave: arquitectura, diseño, estructura, planteamiento estructural, proyecto arquitectónico, Nueva Galería Nacional de Berlín, Ludwig Mies van der Rohe.
AbstractThis research article, through the analysis of plans, images, and bibliography, aims to determine the influence that the structural approach and solution have had on the architectural result of the new National Gallery of Berlin (design: 1962-1965, construction: 1965-1968) designed by the German architect Ludwig Mies van der Rohe (1886-1969), defining the strategies based on the structural theory that determine the morphological result of the project. Therefore, the analysis will present in a descriptive manner the structural concepts evident in the work and that determine the formal result and the functional organization of the building, showing the interaction that these concepts have in the way of obtaining project solutions by the architectMies van der Rohe. Keywords: architecture, design, structure, structural approach, architectural project, New National Gallery of Berlin, Ludwig Mies van der Rohe.
TINJAUAN SOSIOLOGI HUKUM TERHADAP SESERAHAN ADAT MASYARAKAT LAMPUNG
Authors: Ulandari Febriyana latika , Efa Rodiah Efa 
Published: December 2024

Tujuan dilakukan penelitian ini adalah untuk mengetahui seserahan adat masyarakat Lampung dalam tinjauan sosiologi hukum dan akan mengungkapkan beberapa konsep seserahan adat Lampung yang terjadi dalam lingkungan masyarakat yang sudah menjadi kebiasaan hingga saat ini dalam hukum Islam dan sosiologi hukum. Penelitian ini menggunakan metode kepustakaan (library research) atau kualitatif, pendekatan yang digunakan adalah pendekatan normative. Hasil penelitian ini adalah seserahan yaitu memberikan seserahan kepada mempelai wanita untuk dibelikan perabotan rumah tangga yang akan dibawa ketika prosesi upacara perkawinan yang mana biaya pembelian barang tersebut dari uang yang diberikan oleh pihak pria di mana dalam penentuannya pihak keluarga wanita yang menentukan sesuai kemampuan pria dan mayoritas kebanyakan berdasarkan kelas sosial atau dengan istilah lain pemberian seserahan diberikan oleh orang tua atau kerabat dari mempelai wanita pemberiannya bisa ditangguhkan atau dijanjikan oleh kerabat dari mempelai wanita ketika berlangsungnya upacara perkawinan. Tinjauan sosiologi hukum masyarakat lampung terbiasa dengan konsep seserahan ini, dan apabila ada yang tidak sesuai adat maka tidak ada sanksi sosial dalam masyarakat, namun masyarakat akan memperbincangkan hal tersebut. Maka dari itu carilah pasangan yang kafa’ah agar tidak ada kesenjangan sosialKata Kunci : Sosiologi Hukum, SeserahanAbstract : The purpose of this research is to find out the traditional heritage of the Lampung community in a sociological review of law and to reveal some of the concepts of Lampung's customary inheritance that occur in the community which has become a habit to date in Islamic law and legal sociology. This study uses the method of literature (library research) or qualitative, the approach used is a normative approach. The results of this study are gifts, namely giving offerings to the bride to buy household furniture to be brought during the wedding ceremony procession where the cost of purchasing these items is from the money given by the man where in determining the woman's family determines according to the ability of the man and the majority mostly based on social class or in other terms the gift is given by the parents or relatives of the bride, the gift can be postponed or promised by the relatives of the bride during the wedding ceremony. Sociological review of law, the people of Lampung are used to this concept of surrender, and if something is not according to custom, there will be no social sanctions in society, but the community will discuss it. Therefore, look for a partner who is kafa'ah so that there is no social gap. Keyword : Legal Sociology, Delivery Money
PERLINDUNGAN HUKUM TERHADAP PEMENUHAN HAK NARAPIDANA LANJUT USIA DI LEMBAGA PEMASYARAKATAN KELAS IIA KUNINGAN
Authors: Hidayat Sarip , Budiman Haris , Yuhandra Erga , Akhmaddhian Suwari 
Published: December 2024

Prisoner carry on age own condition physical and mental already No as good as prisoners who are still young, so institution correctional must give treatment special in fulfillment rights as a prisoner elderly. A phenomenon discovered by researchers at Correctional Institutions Class IIA Kuningan that is disturbed health prisoner elderly, not yet exists block special prisoner elderly, and less maximum coaching to prisoner elderly. Research methods nature descriptive-exploratory with approach juridical empirical. Results and Discussion study that arrangement protection law right prisoner carry on age in Correctional Institutions Class IIA Kuningan that is Constitution Number 22 of 2022 Article 7, article 9 and article 10 paragraphs (1,2,3 and 4) concerning Correctional that right prisoner covers worship, care or health, education and teaching (coaching), proper food, delivery complaint, follows media broadcasts, visits family , wages and allowances, remission, assimilation, liberation conditional, and leave approaching free; implementation protection to right prisoner carry on age in Correctional Institutions Class IIA Kuningan Already done but Still not enough effective, special in matter right maintenance or health as well as right education and teaching (coaching). Maintenance rights or health Not yet effective Because No exists doctor special whereas right education and teaching (coaching) not yet effective Because lack of ability prisoner in understand material presented​ in coaching . Apart from that, not yet exists block special prisoner carry on age so that the education and teaching (coaching) process is lacking walk with maximum.
Keywords: protection, prisoners, continue​ age.
Tet2-mediated clonal hematopoiesis modestly improves neurological deficits and is associated with inflammation resolution in the subacute phase of experimental stroke
Authors: Evans Megan A. , Chavkin Nicholas W. , Sano Soichi , Sun Hanna , Sardana Taneesha , Ravi Ramya , Doviak Heather , Wang Ying , Yura Yoshimitsu , Polizio Ariel H. , Horitani Keita , Ogawa Hayato , Hirschi Karen K. , Walsh Kenneth 
Published: December 2024

IntroductionRecent work has revealed that clonal hematopoiesis (CH) is associated with a higher risk of numerous age-related diseases, including ischemic stroke, however little is known about whether it influences stroke outcome independent of its widespread effects on cardiovascular disease. Studies suggest that leukocytes carrying CH driver mutations have an enhanced inflammatory profile, which could conceivably exacerbate brain injury after a stroke.MethodsUsing a competitive bone marrow transplant model of Tet2-mediated CH, we tested the hypothesis that CH would lead to a poorer outcome after ischemic stroke by augmenting brain inflammation. Stroke was induced in mice by middle cerebral artery occlusion and neurological outcome was assessed at acute (24 h) and subacute (14 d) timepoints. Brains were collected at both time points for histological, immunofluorescence and gene expression assays.ResultsUnexpectedly, Tet2-mediated CH had no effect on acute stroke outcome but led to a reduction in neurological deficits during the subacute phase. This improved neurological outcome was associated with lower levels of brain inflammation as evidenced by lower transcript levels of various inflammatory molecules alongside reduced astrogliosis.DiscussionThese findings suggest that Tet2-mediated CH may have beneficial effects on outcome after stroke, contrasting with the conventional understanding of CH whereby leukocytes with driver mutations promote disease by exacerbating inflammation.
Integration analysis of microRNAs as potential biomarkers in early-stage lung adenocarcinoma: the diagnostic and therapeutic significance of miR-183-3p
Authors: Huang Guodong , Liu Yuxia , Li Lisha , Li Bing , Jiang Ting , Cao Yufeng , Yang Xiaoping , Liu Xinning , Qu Honglin , Li Shitao , Zheng Xin 
Published: December 2024

IntroductionLung adenocarcinoma (LUAD) poses a significant therapeutic challenge, primarily due to delayed diagnosis and the limited efficacy of existing treatments.MethodsTo understand the pathogenesis and identify diagnostic biomarkers for LUAD in the early stage, we investigated differential miRNA expression in 33 stage I LUAD patients between tumor and matched paracancerous tissues by Illumina Sequencing. Target genes of differentially expressed miRNAs were predicted using TargetScan and miRDB databases and further analyzed by GO and KEGG pathway enrichment analysis. The miRNAs expression results were verified using qRT-PCR. Additionally, we evaluated the clinical significance of miRNAs by the TCGA database. miR-183-3p was chosen for subsequent biological functional studies by cell proliferation assays, cell migration and cell invasion assays, cell apoptosis and cell cycle assays in LUAD cells. The clinical relevance target genes of miR-183-3p were predicted by TargetScan databases and bioinformatics assays. Gene-specific experimental validation was performed using qRT-PCR, western blotting and luciferase reporter assays.ResultsWe identified 36 differentially expressed miRNAs between LUAD tissues and matched paracancerous tissues. Target genes for these miRNAs revealed associations with processes and pathways such as RNA biosynthesis, intracellular signaling, protein transport, and the Ras, MAPK, and PI3K-AKT pathways. The qRT-PCR results were in alignment with the sequencing data for 19 out of these 21 miRNAs which not yet implicated in LUAD, 13 were up-regulated, 6 were down-regulated. The clinical relevance assays showed that 5 up-regulated miRNAs have diagnostic value for LUAD. miR-183-3p showed significant advantages in the result of sequencing, qRT-PCR, and clinical relevance assay. Biological functional assays showed that miR-183-3p emerged as a key regulator, promoting LUAD cell proliferation, decreasing apoptosis, and augmenting migration and invasion capabilities. The clinical relevance assays and experimental validation showed SESN1 as a clinical significance target of miR-183-3p.DiscussionOur study lays the foundation for investigating miRNAs with diagnostic significance in early-stage LUAD, pointing out that inhibition of miR-183-3p may serve as a novel therapeutic in LUAD.
Phytochemical characterization and anti-arthritic potential of green-synthesized CuO nanoparticles derived from the Bistorta amplexicaulis root extract
Authors: Babar Mahrukh , Aslam Bilal , Faisal Muhammad Naeem , Malik Abdul , Akhtar Suhail , Fatima Sabiha , Majeed Wafa , Umer Asher , Farooq Muhammad Akmal 
Published: December 2024

IntroductionRheumatoid arthritis is an autoimmune disease that mainly causes joint damage. The patient experiences loss of appetite, pain, fever, and fatigue. The present study was designed to phytochemically characterize and evaluate the anti-arthritic activity of green-synthesized copper oxide (CuO) nanoparticles (NPs) using the hydroalcoholic extract of Bistorta amplexicaulis roots in an adjuvant-induced arthritic rat model.Material and MethodsFor this purpose, crude powdered plant material was used for proximate analysis, and the plant extract was assessed for qualitative phytochemical analysis, mineral contents, and flavonoid and phenolic contents, as well as quantitative phytochemical analysis through reversed-phase high-performance liquid chromatography (RP-HPLC) and Fourier-transform infrared (FTIR) spectroscopy. The in vitro antioxidant activity of both extracts was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The biosynthesized CuO NPs from the Bistorta amplexicaulis extract showed anti-arthritic activity due to the presence of flavonoids and phenols, which showed a pain reliever effect by blocking the cyclo-oxygenase enzyme and has immune suppressant activity, thus securing the joint from destruction. The nanoparticles were characterized by zeta size, zeta potential, scanning electron microscopy (SEM), and FTIR spectroscopy. Forty-eight albino rats were divided randomly into six treatment groups.Results and DisscussionThe zeta size and zeta potential of the nanoparticles were 186.8 nm and −9.23 mV, respectively. Joint stiffness, spleen weight, thymus weight, and paw thickness showed a significant decrease after treatment with NPs. The hematological parameters such as red blood cells (RBCs) and hemoglobin showed a significant increase, while platelets and white blood cells (WBCs) showed a significant decrease in NP-treated groups. C-reactive protein (CRP), rheumatoid factor (RF), liver and kidney function biomarkers, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels showed a significant decrease at both low and high doses of green-synthesized CuO nanoparticles from the Bistorta amplexicaulis root extract. The final data were analyzed by one way and two-way analysis of variance (ANOVA) and Tukey’s multi-comparison test.ConclusionSo, from this study, it was concluded that both the plant root extract and green-synthesized CuO nanoparticles have anti-arthritic potential, but CuO NPs showed remarkable results.
Naoqing formula alleviates acute ischaemic stroke-induced ferroptosis via activating Nrf2/xCT/GPX4 pathway
Authors: Ye Yujun , Xie Xuexin , Bi Yiming , Liu Qing , Weng Xuliang , Qiu Lingling , Zhao He , Hei Shangyan , Yang Ling , Wang Chengyin , Zhu Weifeng , Zeng Ting 
Published: December 2024

BackgroundsFerroptosis is a form of regulated cell death. The accumulation of iron in the brain is linked to trigger ferroptosis after an ischaemic stroke (IS). Naoqing formula (NQ) is a traditional Chinese medicine metabolites with the clinical function of activating blood circulation, which is applied to treat IS clinically in China.MethodsMice and SH-SY5Y cells were utilized to investigate the protective effects and the underlying mechanism of NQ against middle cerebral artery occlusion (MCAO) induced acute ischaemic stroke (AIS) and neuronal cellular ferroptosis caused by ferroptosis inducer Erastin in vitro and in vivo. Utilizing molecular biological techniques, transcriptomics, and proteomics analyses, the role of NQ in Nrf2 regulation and ferroptosis was evaluated through the pharmacologic inhibition of Nrf2.ResultsNQ attenuated AIS-induced neuronal damage and cerebral infarction by increasing cortical blood flow (CBF). Transcriptomics and proteomics analyses revealed that NQ might regulate lipid and iron metabolism through Nrf2 pathway. Additionally, NQ can protect AIS from ferroptosis by reducing oxidative stress and iron overload. Meanwhile, Nrf2, solute carrier family 7 member 11 (SLC7A11; also known as xCT) and glutathione peroxidase 4 (GPX4) were upregulated in NQ-treated AIS mice. Consistent with the results in vivo, NQ led to ferroptosis resistance upon exposure to a ferroptosis-inducing compound through activation of Nrf2/xCT/GPX4 pathway in vitro. Notably, in vivo inhibition of Nrf2 expression by ML385 aggravated the ferroptotic events and weakened the neuroprotective effect of NQ as well as subsequently reduced the expression of xCT and GPX4.ConclusionThis study demonstrated that NQ protected against AIS via suppression of ferroptosis and oxidative stress, which were largely dependent on the upregulation of Nrf2 pathway.
The mediation effect of peer relation and positive emotion between campus sports atmosphere and teenagers’ subjective well-being
Authors: Cheng Weibo , Jiao Long 
Published: December 2024

BackgroundThe healthy growth of young people affects the future of every country and nation. Their physical and psychological health problems have long been the focal point of every country. The purpose of this study is to investigate the influence of campus sports atmosphere on the teenagers’ subjective well-being.MethodThis study was conducted among 10 to 15 year old teenagers in Jinan City, by means of campus sports atmosphere, peer relation, positive emotion and subjective well-being. The original data is exported in Excel format from Wenjuanxing Platform, and SPSS 26.0 is used to perform descriptive statistics, reliability, and correlation analysis.ResultsThe correlation coefficient of campus sports atmosphere, peer relations, positive emotion, and teenagers’ subjective well-being is significant; the results showed that the campus sports atmosphere had a positive predictive effect on the peer relationship (β = 0.699, t = 17.729, p &lt; 0.01), and positive emotion (β = 0.38, t = 16.783, p &lt; 0.01). Campus sports atmosphere can predict the teenagers’ subjective well-being positively (β = 0.289, t = 14.723, p &lt; 0.01); The relationship between peer relations and positive emotion can predict the teenagers’ subjective well-being positively (β = 0.292, t = 15.24, p &lt; 0.01; β = 0.355, t = 18.669, p &lt; 0.01); Through Bootstrap Testing, we find that the campus sports atmosphere has a significant positive influence on the teenagers’ subjective well-being, which is 0.4969; The influence of the relationship between the campus sports atmosphere and the teenagers’ subjective well-being was significant, and the total indirect influence was 0.4352.ConclusionThe campus sports atmosphere not only influences teenagers’ subjective well-being directly, but also improves their well-being by the mediation of peer relations and positive emotion.