bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural network implementation of controllers for multi-channel objects synthesized by polynomial method
Authors: Voevoda A , Shipagin V I 
Published: November 2020

Abstract
The implementation of neural network multichannel controllers synthesized by polynomial matrix decomposition is analysed. Objects and controllers are assumed to be linear; these allow them to be described by matrix transfer functions. The transfer function of the object is converted to the right polynomial matrix inter-simple decomposition. The transfer function of the controller is sought in the form of a left polynomial matrix of inter-simple decomposition that allows leading the characteristic matrix to the form of a linear matrix polynomial equation with two matrix indeterminates. This equation is solved by leading to a matrix equation with numeric matrix indeterminates. Then the controller equation is converted to a discrete equation. The discrete sampling step is chosen small enough to allow the systems with continuous and discrete controllers have sufficiently close transient processes. The discrete controller is converted to a structure including delay elements, adder units and amplification coefficients. Then this structure is presented in the form of a set of neurons. The operation of the algorithm is illustrated by the example of the synthesis of an unstable inverted pendulum control, which includes two PID controllers. Possible increases in neuro controller performance are demonstrated. Two PID controllers are combined into one neural network in order to further optimization.
Algorithm for regional clustering of road freight transport in the Russian Federation
Authors: Gavrilenko N G 
Published: November 2020

Abstract
The road transport system of the Russian Federation is a system for managing road freight transport, which includes three levels: the macro-level is the federal level of management, the meso-level is the regional level of management, and the micro-level is the level of a motor transport enterprise (transport subdivision). According to the Transport Strategy of the Russian Federation, the system of road freight transport is faced with the tasks of increasing competitiveness, improving quality indicators, safety and environmental friendliness of transportation. Within the framework of this paper, the meso-level of management is considered, and the solution of the indicated tasks is seen through the formation of clusters. The study was based on a review of scientific literature, study of data from the Federal State Statistics Service, the use of expert and logical methods, methods of description and analogy, as well as correlation analysis and mathematical optimization. The presented clustering algorithm made it possible to distinguish two groups of regions. The first group is a group of innovators, regions with the greatest opportunities for the implementation and dissemination of innovations. The regions of this group are the cores of clusters. The second group is a group of imitators, regions with less innovative potential. The regions were grouped around the cores according to geography and the dominant mode of transportation. As a result, seven regional clusters were obtained. Optimization measures are aimed at increasing the efficiency of management in the field of road freight transport and enhancing the development and dissemination of innovations at the meso-level.
Implementation of investment and construction projects as part of the interior image formation
Authors: Ovchinnikova S , Sekisov A , Shinkareva I , Schneider E , Tamoshkina E 
Published: November 2020

Abstract
A methodology for the functional and artistic image of the interior as part of the implementation of investment and construction projects for a two-room apartment in the Scottish style is developed in the paper. Pre-project analysis, concept of the project and the formation of the visual environment of the interior based on consumer preferences were carried out. The initial stage of the formation of the functional and artistic image of the interior is described in the pre-project study: the design environment was analyzed taking into account the lifestyle and preferences of the customer. The choice of the style of the space being developed was based on the terms of reference drawn up together with the customers. The Scottish style was identified as a style solution. The aesthetic harmonization of the interior space was developed on the basis of the chosen style. The composition of the space of the room is focused on the organization of the main living areas of residents, hence the layout of the apartment was formed. The basis for the design methods for the functional and artistic image of the interior in the framework of the implementation of investment and construction projects for living space is based on the analog method. The additional methods are the method of getting used to the role, the method of aggregation and the piece method. The Autodesk 3ds MAX information environment has become a means of visual implementation of the interior. The choice of the program was based on realistic visualizations of the interior space. The planning solution of the developed environment was carried out in the ARCHICAD information environment. For high-quality preparation of textures, the Adobe Photoshop and CorelDRAW graphic editors were used.
On Possible Security Risks of Contract Tenders for Developers
Authors: Uskov V , Shariapova E , Ivanova A 
Published: November 2020

Abstract
Today, electronic processes of various types, including tenders and bidding, gain more relevance in the era of digital economy and informational technologies. Tender is a relatively recent procedure, though it is already undergoing changes. New ways to conduct tenders and bidding procedures are driven by urge for efficiency. The authors try to elicit the efficiency element for developers that participate in bidding auctions for development of built-up areas, integrated urban development and construction of standard housing. The paper pinpoints the possible risks, which may occur if procedure rules, including electronic tenders, are failed to comply with. The authors attempt to protect and maintain regulations for tenders that are to be held according to the law. Underdeveloped and haphazard regulatory framework may place national security in jeopardy. Thus, the work considers options to prevent and curb possible threats.
Bioinert coatings of Ti-Ta-N for medical implants obtained by electric explosion spraying and subsequent electron-ion-plasma modification
Authors: Romanov Denis A , Sosonin Kirill V , Pronin Sergei Yu , Moskovskii Stanislav V , Gromov Victor E , Bataev Vladimir A , Ivanov Yuriy F , Semin Alexander P 
Published: November 2020

Abstract
The purpose of the research was to form a Ti-Ta-N- system bioinert coating on Ti6Al4V alloy surface as well as to study its structure and properties. The main contribution of the research is in the following. Electro-explosion spraying of tantalum coating on VT6 titanium alloy surface was pioneered in the research. After that the processing of the coating by low-energy high-current electron beam and subsequent nitriding was carried out in a single technological cycle. It has been established that a nanocrystalline coating based on tantalum, nitrogen and titanium was formed as a result of the technological operations. The phase composition of the coatings has been detected. The variations in crystal lattice parameters being formed in coating of phases and coherent scallering regions of these phases depending on power density of electron beam have been determined. Structural characteristics of the coatings at nano- and microlevel have been detected. Tests of coatings for nanohardness, the Young modulus, wear resistance and friction factor have been carried out. By all technical characteristics Ti-Ta-N-system coating exceeds titanium of VT6 grade. The cause of the increase in mechanical characteristics of the Ti-Ta-N-system coating is their nanostructural state and strengthening phases. Tests for proliferation activity of fibroplasts and antimicrobial activity have shown better results in comparison with VT6 titanium alloy as well. It is due to escape of vanadium ions from VT6 alloy into nutrient cell medium and their destructive effect on cell cultures. Variations in proliferation and antimicrobial activity develop due to amplification of cell proliferation. A complex of the obtained characteristics makes it possible to recommend Ti-Ta-N-system coating for its application as a bioinert coating on different implants in furure.
The intrinsic axon regenerative properties of mature neurons after injury
Authors: Liu Chunfeng , Liu Jinlian , Liu Chaoqun , Zhou Qing , Zhou Yaodong , Zhang Boyin , Saijilafu  
Published: November 2020

Abstract
Thousands of nerve injuries occur in the world each year. Axon regeneration is a very critical process for the restoration of the injured nervous system’s function. However, the precise molecular mechanism or signaling cascades that control axon regeneration are not clearly understood, especially in mammals. Therefore, there is almost no ideal treatment method to repair the nervous system’s injury until now. Mammalian axonal regeneration requires multiple signaling pathways to coordinately regulate gene expression in soma and assembly of the cytoskeleton protein in the growth cone. A better understanding of their molecular mechanisms, such as axon regeneration regulatory signaling cascades, will be helpful in developing new treatment strategies for promoting axon regeneration. In this review, we mainly focus on describing these regeneration-associated signaling cascades, which regulate axon regeneration.
Reduction of phone interruptions post implementation of a central call center in community pharmacies of an academic health system
Authors: Caffiero Nicole A , Nickman Nancy A , Drews Frank A , King Jordan B , Moorman Krystal , Tyler Linda S 
Published: November 2020

Abstract

Purpose
A pharmacy services call center (PSCC) was implemented to centralize pharmacy phone calls and reduce interruptions of dispensing activities in 7 community pharmacies of an academic health center. An evaluation was conducted to define, quantify, and compare the numbers and types of phone interruptions before and 3 months after PSCC implementation.

Methods
Through structured, direct observation of pharmacy staff, the numbers and types of “breaks in task” (BIT) due to phone interruptions and other distractions were identified. A standardized data collection tool formatted on tablet computers was used by trained observers to document BIT for 3-hour time blocks on 5 consecutive business days (2 days of pharmacist observation and 3 days of technician observation, for a total of 10 observation days per pharmacy).

Results
Over 5,000 prescriptions were processed during 414 hours of observation (13.3 prescriptions per observation hour). Overall, BIT due to phone interruptions totaled 2.2 BIT per observation hour, with those interruptions reduced by 46.4% overall after PSCC implementation (by 30.0% in 4 small pharmacies and by 57.5% in 3 large pharmacies). Technicians were more likely than pharmacists to be interrupted by phone vs nonphone BIT (eg, distraction by another technician, pharmacist, or patient). Comparison of phone vs nonphone BIT suggested an overall 46.0% reduction in phone BIT in all pharmacies (reductions of 42.4% and 45.0% in large and small pharmacies, respectively).

Conclusion
PSCC implementation noticeably decreased the amount of phone interruptions and distractions for employees.
The arbitrability of civil fraud in India: analysing the Supreme Court of India’s decision in Avitel Post Studioz Ltd
Authors: Bhattacharyya Sayantan , Ranawat Moksh 
Published: November 2020

ABSTRACT
The arbitrability of civil fraud under Indian jurisprudence had been a victim of vaguely worded and scattered tests for a considerable period of time. In its recent decision in Avitel Post Studioz Ltd v HSBC PI Holdings (Mauritius) Ltd., the Supreme Court of India finally put the uncertainties regarding the matter to rest by harmonizing the existing law on it and crystallizing the ‘public flavour’ standard. According to this standard, allegations of fraud which find their roots in civil law and have no public considerations shall now be considered arbitrable in India. The judgment also clarified the impact that parallel criminal proceedings based on the same set of facts would have on the arbitrability of the civil aspects of such fraud, bringing necessary clarity to the erstwhile regime. In this article, we explore the implications of this judgment in detail, highlighting its relevance for arbitration in India, and how it impacts the jurisprudential position on the arbitrability of fraud in the country.
Comprehensive pathway enrichment analysis workflows: COVID-19 case study
Authors: Agapito Giuseppe , Pastrello Chiara , Jurisica Igor 
Published: November 2020

Abstract
The coronavirus disease 2019 (COVID-19) outbreak due to the novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been classified as a pandemic disease by the World Health Organization on the 12th March 2020. This world-wide crisis created an urgent need to identify effective countermeasures against SARS-CoV-2. In silico methods, artificial intelligence and bioinformatics analysis pipelines provide effective and useful infrastructure for comprehensive interrogation and interpretation of available data, helping to find biomarkers, explainable models and eventually cures. One class of such tools, pathway enrichment analysis (PEA) methods, helps researchers to find possible key targets present in biological pathways of host cells that are targeted by SARS-CoV-2. Since many software tools are available, it is not easy for non-computational users to choose the best one for their needs. In this paper, we highlight how to choose the most suitable PEA method based on the type of COVID-19 data to analyze. We aim to provide a comprehensive overview of PEA techniques and the tools that implement them.
A Bayesian linear mixed model for prediction of complex traits
Authors: Hai Yang , Wen Yalu 
Published: November 2020

Abstract

Motivation
Accurate disease risk prediction is essential for precision medicine. Existing models either assume that diseases are caused by groups of predictors with small-to-moderate effects or a few isolated predictors with large effects. Their performance can be sensitive to the underlying disease mechanisms, which are usually unknown in advance.

Results
We developed a Bayesian linear mixed model (BLMM), where genetic effects were modelled using a hybrid of the sparsity regression and linear mixed model with multiple random effects. The parameters in BLMM were inferred through a computationally efficient variational Bayes algorithm. The proposed method can resemble the shape of the true effect size distributions, captures the predictive effects from both common and rare variants, and is robust against various disease models. Through extensive simulations and the application to a whole-genome sequencing dataset obtained from the Alzheimer’s Disease Neuroimaging Initiatives, we have demonstrated that BLMM has better prediction performance than existing methods and can detect variables and/or genetic regions that are predictive.

Availabilityand implementation
The R-package is available at https://github.com/yhai943/BLMM.

Supplementary information
Supplementary data are available at Bioinformatics online.
Post-traumatic Growth in Inflammatory Bowel Disease Patients: The Role of Illness Cognitions and Physical Quality of Life
Authors: Hamama-Raz Yaira , Nativ Shlomit , Hamama Liat 
Published: November 2020

Abstract

Background and Aims
The symptoms and complications associated with inflammatory bowel disease [IBD] have been found to be associated significantly with impaired health-related quality of life. Nevertheless, there may also be a positive psychological change such as post-traumatic growth, as was noted among patients with other chronic diseases, but this remains understudied in patients with IBD. In this study, we explored associations between post-traumatic growth and illness cognitions (helplessness, acceptance and perceived benefits). In addition, we evaluated whether physical quality of life in IBD patients mediates the link between illness cognitions and post-traumatic growth.

Methods
The study employed a cross-sectional design. Two hundred patients diagnosed with IBD completed questionnaires assessing illness cognitions, physical quality of life and post-traumatic growth.

Results
There was a negative association between illness cognition of helplessness and post-traumatic growth, and positive associations between illness cognitions of acceptance and illness cognitions of perceived benefits, and post-traumatic growth. In addition, the association between an illness cognition of helplessness and post-traumatic growth was mediated via physical quality of life. Yet, the signs of the direct and the indirect paths of an illness cognition of helplessness on post-traumatic growth were opposite.

Conclusions
This study extends the literature on the role of illness cognitions as an important component in facilitating the process of post-traumatic growth among IBD patients. Based on the findings, the management of IBD patients should incorporate more interventions aimed at exploring cognitive aspects of the illness in order to improve physical quality of life and enhance personal growth.
Contact-free sensor signals as a new digital biomarker for cardiovascular disease: chances and challenges
Authors: Saner Hugo , Knobel Samuel Elia Johannes , Schuetz Narayan , Nef Tobias 
Published: November 2020

Abstract
Multiple sensor systems are used to monitor physiological parameters, activities of daily living and behaviour. Digital biomarkers can be extracted and used as indicators for health and disease. Signal acquisition is either by object sensors, wearable sensors, or contact-free sensors including cameras, pressure sensors, non-contact capacitively coupled electrocardiogram (cECG), radar, and passive infrared motion sensors. This review summarizes contemporary knowledge of the use of contact-free sensors for patients with cardiovascular disease and healthy subjects following the PRISMA declaration. Chances and challenges are discussed. Thirty-six publications were rated to be of medium (31) or high (5) relevance. Results are best for monitoring of heart rate and heart rate variability using cardiac vibration, facial camera, or cECG; for respiration using cardiac vibration, cECG, or camera; and for sleep using ballistocardiography. Early results from radar sensors to monitor vital signs are promising. Contact-free sensors are little invasive, well accepted and suitable for long-term monitoring in particular in patient’s homes. A major problem are motion artefacts. Results from long-term use in larger patient cohorts are still lacking, but the technology is about to emerge the market and we can expect to see more clinical results in the near future.
The impact of COVID-19 restriction measures on loneliness among older adults in Austria
Authors: Stolz Erwin , Mayerl Hannes , Freidl Wolfgang 
Published: November 2020

AbstractBackgroundTo halt the spread of COVID-19, Austria implemented a 7-week ‘lockdown’ in March/April 2020. We assess whether the ensuing reduction in social contacts led to increased loneliness among older adults (60+).MethodsThree analyses were conducted: (i) a comparison between pre-pandemic (SHARE: 2013–17) and pandemic (May 2020) levels of loneliness (UCLA-3 scale), (ii) an assessment of the cross-sectional correlation between being affected by COVID-19 restriction measures and loneliness (May 2020) and (iii) a longitudinal analysis of weekly changes (March–June 2020) in loneliness (Corona panel).ResultsWe found (i) increased loneliness in 2020 compared with previous years, (ii) a moderate positive association between the number of restriction measures older adults were affected from and their loneliness and (iii) that loneliness was higher during ‘lockdown’ compared to the subsequent re-opening phase, particularly among those who live alone.ConclusionsWe found evidence that COVID-19 restriction measures in Austria have indeed resulted in increased levels of loneliness among older adults. However, these effects seem to be short-lived, and thus no strong negative consequences for older adults’ mental health are expected. Nonetheless, the effects on loneliness, and subsequent mental health issues, could be both more long-lasting and severe if future restriction measures are enacted repeatedly and/or over longer time periods.
The Work-For-Hire Doctrine in Russia: Recent Law Enforcement Trends
Authors: Galoyan Arman , Glonina Vera 
Published: November 2020

Abstract
This paper aims to describe the work-for-hire regime in Russia and provide the readers with practical information on the due formalization of relations between a company and its employees with regard to the intellectual property (hereinafter ‘IP’) that they create. We have reviewed recent high-profile cases (e.g. Rambler v NGINX, Mr. Mamichev v Interveeam LLC and Veeam Software, Laboratory Kaspersky v Cybersecurity Solutions) that reveal the most common problems related to the work-for-hire regime. Based on our analysis of the applicable legislation, court practice and doctrine, we have given some practical tips and recommendations on how to avoid widespread challenges concerning works for hire in Russia.
30-Day perioperative mortality following venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock in patients with normal preoperative ejection fraction
Authors: Menon Priya R , Flo Forner Anna , Marin-Cuartas Mateo , Lehmann Sven , Saeed Diyar , Ginther André , Borger Michael A , Ender Jörg 
Published: November 2020

Abstract

OBJECTIVES
Assessment of early outcomes in patients with normal preoperative left ventricular ejection fraction (LVEF) in whom venoarterial extracorporeal membrane oxygenation (VA-ECMO) was implanted for postcardiotomy cardiogenic shock (PCCS) during the first postoperative 48 h.

METHODS
Retrospective single-centre analysis in adult patients with normal LVEF, who received VA-ECMO support for PCCS from May 1998 to May 2018. The primary outcome was 30-day perioperative mortality during the index hospitalization.

RESULTS
A total of 62 125 adult patients underwent cardiac surgery at our institution during the study period. Among them, 173 patients (0.3%) with normal preoperative LVEF required VA-ECMO for PCCS. Among them, 71 (41.1%) patients presented PCCS due to coronary malperfusion and in 102 (58.9%) patients, no evident cause was found for PCCS. Median duration of VA-ECMO support was 5 days (interquartile range 2–8 days). A total of 135 (78.0%) patients presented VA-ECMO-related complications and the overall 30-day perioperative mortality was 57.8%. Independent predictors of mortality were: lactate level just before VA-ECMO implantation [odds ratio (OR) 1.27; P &lt; 0.001], major bleeding during VA-ECMO (OR 3.76; P = 0.001), prolonged cardiopulmonary bypass time (OR 1.01; P &lt; 0.001) and female gender (OR 4.87; P &lt; 0.001).

CONCLUSIONS
Mortality rates of VA-ECMO in PCCS patients are high, even in those with preoperative normal LVEF. Coronary problems are an important cause of PCCS; however, the aetiology remains unknown in the vast majority of the cases. The implantation of VA-ECMO before development of tissue hypoperfusion and the control of VA-ECMO-associated complications are the most important prognostic factors in PCCS patients. Lactate levels may help guide timing of VA-ECMO implantation and define the extent of therapeutic effort.