bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study
Authors:   the Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), and the MRI-Genetics Interface Exploration (MRI-GENIE) Study, Frid Petrea , Drake Mattias , Giese A. K. , Wasselius J. , Schirmer M. D. , Donahue K. L. , Cloonan L. , Irie R. , Bouts M. J. R. J. , McIntosh E. C. , Mocking S. J. T. , Dalca A. V. , Sridharan R. , Xu H. , Giralt-Steinhauer E. , Holmegaard L. , Jood K. , Roquer J. , Cole J. W. , McArdle P. F. , Broderick J. P. , Jimenez-Conde J. , Jern C. , Kissela B. M. , Kleindorfer D. O. , Lemmens R. , Meschia J. F. , Rundek T. , Sacco R. L. , Schmidt R. , Sharma P. , Slowik A. , Thijs V. , Woo D. , Worrall B. B. , Kittner S. J. , Mitchell B. D. , Petersson J. , Rosand J. , Golland P. , Wu O. , Rost N. S. , Lindgren A. 
Published: November 2019

Abstract

Objective
Posterior circulation ischemic stroke (PCiS) constitutes 20–30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. Such information might guide clinical decision making and prevention strategies. We studied risk factors and ischemic stroke subtypes in PCiS vs. ACiS and lesion location on magnetic resonance imaging (MRI) in PCiS.

Methods
Out of 3,301 MRIs from 12 sites in the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN), we included 2,381 cases with acute DWI lesions. The definition of ACiS or PCiS was based on lesion location. We compared the groups using Chi-squared and logistic regression.

Results
PCiS occurred in 718 (30%) patients and ACiS in 1663 (70%). Diabetes and male sex were more common in PCiS vs. ACiS (diabetes 27% vs. 23%, p < 0.05; male sex 68% vs. 58%, p < 0.001). Both were independently associated with PCiS (diabetes, OR = 1.29; 95% CI 1.04–1.61; male sex, OR = 1.46; 95% CI 1.21–1.78). ACiS more commonly had large artery atherosclerosis (25% vs. 20%, p < 0.01) and cardioembolic mechanisms (17% vs. 11%, p < 0.001) compared to PCiS. Small artery occlusion was more common in PCiS vs. ACiS (20% vs. 14%, p < 0.001). Small artery occlusion accounted for 47% of solitary brainstem infarctions.

Conclusion
Ischemic stroke subtypes differ between the two phenotypes. Diabetes and male sex have a stronger association with PCiS than ACiS. Definitive MRI-based PCiS diagnosis aids etiological investigation and contributes additional insights into specific risk factors and mechanisms of injury in PCiS.
Computing the Interleaving Distance is NP-Hard
Authors: Bjerkevik Håvard Bakke , Botnan Magnus Bakke , Kerber Michael 
Published: November 2019

Abstract
We show that computing the interleaving distance between two multi-graded persistence modules is NP-hard. More precisely, we show that deciding whether two modules are 1-interleaved is NP-complete, already for bigraded, interval decomposable modules. Our proof is based on previous work showing that a constrained matrix invertibility problem can be reduced to the interleaving distance computation of a special type of persistence modules. We show that this matrix invertibility problem is NP-complete. We also give a slight improvement in the above reduction, showing that also the approximation of the interleaving distance is NP-hard for any approximation factor smaller than 3. Additionally, we obtain corresponding hardness results for the case that the modules are indecomposable, and in the setting of one-sided stability. Furthermore, we show that checking for injections (resp. surjections) between persistence modules is NP-hard. In conjunction with earlier results from computational algebra this gives a complete characterization of the computational complexity of one-sided stability. Lastly, we show that it is in general NP-hard to approximate distances induced by noise systems within a factor of 2.
The Efficacy of a Gambling Prevention Program Among High-School Students
Authors: Calado Filipa , Alexandre Joana , Rosenfeld Liah , Pereira Rafaela , Griffiths Mark D. 
Published: November 2019

Abstract
Youth problem gambling has become an emergent public health issue, and adolescents constitute a vulnerable age group for the development of gambling-related problems. Although there is research concerning the risk factors of youth problem gambling, rigorous evaluations of the effectiveness of preventive initiatives is still rare. The present study evaluated the efficacy of an integrative intervention to prevent youth problem gambling based on a multidimensional set of factors including gambling-related knowledge, misconceptions, attitudes, gambling frequency, amount of money spent, total hours spent gambling per week, and sensation seeking. A pre- and post-test design was performed with 111 Portuguese high-school students randomly assigned to two groups (experimental and control). The findings demonstrated that the intervention was effective in improving correct knowledge about gambling, reducing misconceptions and attitudes, and in decreasing the total hours spent gambling per week. The intervention was also effective in reducing the number of at-risk/problem gamblers during the study period. Furthermore, these findings were stable after a 6-week follow-up. Overall, the intervention program appeared to be effective in correcting some gambling-related behaviours, and provides suggestions for future interventions.
Tigecycline-induced coagulopathy: a literature review
Authors: Cui Nannan , Cai Hongliu , Li Zhitao , Lu Yuting , Wang Guobin , Lu Anwei 
Published: November 2019

Abstract
Background Several adverse reactions to tigecycline, which is widely used in patients with severe infections, have been documented. Coagulopathy is a lesser known side effect of tigecycline. Aim of the review We summarize the characteristics, possible mechanisms, and treatment of tigecycline-induced coagulopathy. Method PubMed, Ovid, Embase, ISI Web of Knowledge, CNKI, and Wanfang were searched up to March 5, 2019. All articles concerning coagulopathy induced by tigecycline were included. The article types and languages were not limited. The retrieved articles were screened by two experienced clinicians by reading the titles, abstracts, and full texts. Results Ultimately, 17 articles were targeted, including 13 case reports and 4 retrospective observational studies. Tigecycline-induced coagulopathy usually manifests as the dose-dependent prolongation of prothrombin time and activated partial thromboplastin time and a reduction in the fibrinogen level. Tigecycline and its metabolites may have multiple effects on coagulation, influencing the extrinsic or intrinsic pathway and even the common pathway. There is no specific treatment for tigecycline-induced coagulopathy, but it can be reversed by withdrawing tigecycline. Conclusion Tigecycline acts on the coagulation system in a dose-dependent manner, and the most severe adverse event is bleeding. Overdose and prolonged use should be avoided, suspected coagulopathy must be recognized in time, and tigecycline should be withdrawn to prevent severe adverse events. Also, drug clearance disorders can develop in patients with liver and/or renal dysfunction. For patients with severe hepatic or renal impairment, the maintenance dose should be reduced, and indicators of coagulation function should be closely monitored.
Measuring originality in science
Authors: Shibayama Sotaro , Wang Jian 
Published: November 2019

AbstractOriginality has self-evident importance for science, but objectively measuring originality poses a formidable challenge. We conceptualise originality as the degree to which a scientific discovery provides subsequent studies with unique knowledge that is not available from previous studies. Accordingly, we operationalise a new measure of originality for individual scientific papers building on the network betweenness centrality concept. Specifically, we measure the originality of a paper based on the directed citation network between its references and the subsequent papers citing it. We demonstrate the validity of this measure using survey information. In particular, we find that the proposed measure is positively correlated with the self-assessed theoretical originality but not with the methodological originality. We also find that originality can be reliably measured with only a small number of subsequent citing papers, which lowers computational cost and contributes to practical utility. The measure also predicts future citations, further confirming its validity. We further characterise the measure to guide its future use.
Feasibility of Solar-Enhanced Drying of Woody Biomass
Authors: Raitila Jyrki , Tsupari Eemeli 
Published: November 2019

Abstract
Sustainable biomass resources are limited and their utilization therefore needs to be more efficient. In addition, there is an urgent need for low-cost energy storage, particularly for solar energy. Drying considerably increases the calorific value of woody biomass, and the resulting dried biomass provides easy seasonal energy storage. The drying both improves the quality of the biomass and extends its storage life. To investigate the technology and feasibility of solar-enhanced drying, several drying experiments were conducted on wood chips in VTT’s 12 kWpeak convective dryer in Jyväskylä, Finland. Drying times varied from 3.5 to 27 h and the final moistures from 12 to 32 w-%. VTT’s experiments show that solar heat can be successfully applied to thermal drying of biomass. The moderate drying temperatures used (typically 20–50 °C) are advantageous for ensuring homogenous drying of wood particles and for preventing changes to the physical structure of the biomass and loss of volatiles. Due to the low efficiency of the system, still in its prototype phase, the calculated payback times were not highly attractive to the entrepreneur. In the experiments, best profitability was achieved by drying seasoned wood, for which a payback time of 12–17 years was estimated for a large scale system such as a biomass terminal. Based on the assumptions that technical improvements are made, the best drying efficiency reached in our experiments is achieved, and some investment subsidy is secured; scale-up is feasible. With these criteria met, the payback time of such a dryer could be brought below 10 years. This requires, however, that drying increases the selling price of wood chips.
Yogic Breathing and Mindfulness as Stress Coping Mediate Positive Health Outcomes of Yoga
Authors: Tellhed Una , Daukantaitė Daiva , Maddux Rachel E. , Svensson Thomas , Melander Olle 
Published: November 2019

AbstractObjectivesDespite accumulating research on yoga and its positive impact on both physiological and psychological health, it is still unclearhowyoga improves health. Two central components of yoga,yogic breathingandmindfulness, may be important mechanisms by which individuals learn to cope with their daily stressors, and thereby reduce their risk of developing stress-related illness. In this study, we experimentally tested whether yogic breathing as a stress coping mechanism and increased mindfulness mediates the psychological health benefits of a yoga interventionMethodsSeventy-one middle-aged adults (78% women;Mage53.5 ± 6.9) who self-rated as moderately stressed were randomly assigned to either a control group or a 5-week yoga intervention called the Yoga and Mindfulness Intervention (YOMI) program. The YOMI combines 60 min of yin yoga practice with 30 min of psychoeducation, administered twice weekly; participants also completed a 5-min breathing exercise as homework daily.ResultsThe YOMI group showed greater reductions in anxiety, depression, and sleep problems compared with controls (R2varied between .09 to .23), and these reductions were statistically mediated by increased use of yogic breathing and a related increase in participants’ overall mindfulness.ConclusionsThese mediation results provide new insights into how yoga improves psychological health and suggests promising implications for policymakers aimed at improving public health.
Noncommutative network models
Authors: Moeller Joe 
Published: November 2019

AbstractNetwork models, which abstractly are given by lax symmetric monoidal functors, are used to construct operads for modeling and designing complex networks. Many common types of networks can be modeled with simple graphs with edges weighted by a monoid. A feature of the ordinary construction of network models is that it imposes commutativity relations between all edge components. Because of this, it cannot be used to model networks with bounded degree. In this paper, we construct the free network model on a given monoid, which can model networks with bounded degree. To do this, we generalize Green’s graph products of groups to pointed categories which are finitely complete and cocomplete.
Dietary inflammatory index potentially increases blood pressure and markers of glucose homeostasis among adults: findings from an updated systematic review and meta-analysis
Authors: Farhangi Mahdieh Abbasalizad , Nikniaz Leila , Nikniaz Zeinab , Dehghan Parvin 
Published: November 2019

AbstractObjective:In the current meta-analysis, we aimed to systematically review and summarize eligible studies for the association between dietary inflammatory index (DII) and blood pressure, hypertension (HTN) and glucose homeostasis biomarkers.Design/Setting:In a systematic search of PubMed, Scopus and Google Scholar electronic databases up to February 2019, relevant studies were included in the literature review. Observational studies evaluating the association between DII and HTN, hyperglycaemia, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), insulin, homeostatic model assessment of insulin resistance (HOMA-IR) and glycated Hb (HbA1c) were included.Participants:Not applicable.Results:Total numbers of studies were as follows: OR for DII and HTN (n 12), OR for DII and hyperglycaemia (n 9), HTN prevalence (n 9), mean (sd) of SBP and DII (n 12), mean (sd) of DBP and DII (n 10), mean (sd) of FBS and DII (n 13), mean (sd) of HbA1c and DII (n 3), mean (sd) of insulin and DII (n 6), mean (sd) of HOMA-IR and DII (n 7). Higher DII scores were associated with higher odds of HTN (OR = 1·13; 95 % CI 1·01, 1·27; P < 0·001), SBP (weighted mean difference (WMD) = 1·230; 95 % CI 0·283, 2·177; P = 0·011), FBS (WMD = 1·083; 95 % CI 0·099, 2·068; P = 0·031), insulin (WMD = 0·829; 95 % CI 0·172, 1·486; P = 0·013), HbA1c (WMD = 0·615; 95 % CI 0·268, 0·961; P = 0·001) and HOMA-IR (WMD = 0·192; 95 % CI 0·023, 0·361; P = 0·026) values compared with lowest DII categories.Conclusions:Lower inflammatory content of diets for prevention of cardiovascular risk factors is recommended.
The Colorado Twin Registry: 2019 Update
Authors: Corley Robin P. , Reynolds Chandra A. , Wadsworth Sally J. , Rhea Sally-Ann , Hewitt John K. 
Published: November 2019

AbstractThe Colorado Twin Registry (CTR) is a population-based registry formed from birth and school records including twins born between 1968 and the present. Two previous reports on the CTR [Rhea et al., (2006). Twin Research and Human Genetics, 9, 941–949; Rhea et al., (2013).Twin Research and Human Genetics, 16, 351–357] covered developments in the CTR through 2012. This report briefly summarizes previously presented material on ascertainment and recruitment and the relationships between samples and studies, discusses developments since 2012 for four previously described twin samples, describes two new samples and their complementary studies and expands on two subjects briefly mentioned in the last report: a history of genotyping efforts involving CTR samples, and a survey of collaborations and consortia in which CTR twins have been included. The CTR remains an active resource for both ongoing, longitudinal research and the recruitment of new twin samples for newly identified research opportunities.
TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample
Authors: Pries Lotta-Katrin , Snijders Clara , Menne-Lothmann Claudia , Decoster Jeroen , van Winkel Ruud , Collip Dina , Delespaul Philippe , De Hert Marc , Derom Catherine , Thiery Evert , Jacobs Nele , Wichers Marieke , Guloksuz Sinan , van Os Jim , Rutten Bart P. F. 
Published: November 2019

AbstractMeta-analyses suggest that clinical psychopathology is preceded by dimensional behavioral and cognitive phenotypes such as psychotic experiences, executive functioning, working memory and affective dysregulation that are determined by the interplay between genetic and nongenetic factors contributing to the severity of psychopathology. The liability to mental ill health can be psychometrically measured using experimental paradigms that assess neurocognitive processes such as salience attribution, sensitivity to social defeat and reward sensitivity. Here, we describe the TwinssCan, a longitudinal general population twin cohort, which comprises 1202 individuals (796 adolescent/young adult twins, 43 siblings and 363 parents) at baseline. The TwinssCan is part of the European Network of National Networks studying Gene-Environment Interactions in Schizophrenia project and recruited from the East Flanders Prospective Twin Survey. The main objective of this project is to understand psychopathology by evaluating the contribution of genetic and nongenetic factors on subclinical expressions of dimensional phenotypes at a young age before the onset of disorder and their association with neurocognitive processes, such as salience attribution, sensitivity to social defeat and reward sensitivity.
A Road Map for Improving the Treatment of Uncertainties in High‐Resolution Regional Carbon Flux Inverse Estimates
Authors: Feng Sha , Lauvaux Thomas , Keller Klaus , Davis Kenneth J. , Rayner Peter , Oda Tomohiro , Gurney Kevin R. 
Published: November 2019

AbstractAtmospheric inversions allow us to estimate the terrestrial carbon sink by combining atmospheric observations with atmospheric transport models. However, these inverse estimates remain highly uncertain. Here we quantify uncertainties in simulations of North American atmospheric CO2 concentrations using a probabilistic approach. We demonstrate that uncertainty in fossil fuel emissions is a key factor in the uncertainty surrounding biospheric flux estimates. We show that atmospheric transport uncertainties in state‐of‐the‐art numerical weather models diminish when averaged over time, while uncertainties in large‐scale CO2 boundary inflow considerably impair our ability to quantify regional fluxes. Current estimates of the North America land sink that neglect the uncertainties in CO2 boundary inflow and fossil fuel emissions are likely overconfident. Our findings suggest that targeted use of new atmospheric observations and improved quantification of uncertainty components are a promising avenue to improve atmospheric inversions with the goal to refine estimates of biospheric CO2 fluxes on regional and continental scales.
Variability of Sediment Accumulation Rates in an Antarctic Fjord
Authors: Eidam E. F. , Nittrouer C. A. , Lundesgaard Ø. , Homolka K. K. , Smith C. R. 
Published: November 2019

AbstractFjords on the West Antarctic Peninsula (WAP) serve as sediment traps, preserving histories of glacial sediment supply. Regional warming trends are expected to change sediment supplies, altering water quality, depositional history, and ecosystem drivers. Our ability to assess magnitudes of these changes is limited by sparse data on modern sediment accumulation. Twelve new cores and four existing cores from Andvord Bay were used to characterize variability in sediment accumulation rates. These range from 1.5 to 7.9 mm/year (0.12 to 0.56 g·cm−2·year−1). Spatial differences and a weak down‐fjord gradient in rates suggest diverse sediment sources, including from outside the fjord. This data set provides a comprehensive assessment of sedimentation during the past century, indicating little change in rates due to recent WAP warming, and sets a benchmark for assessing climate‐related changes in sediment delivery and ecosystem drivers (e.g., burial disturbance) in the fjord over coming decades.
Quantifying the Timescale and Strength of Southern Hemisphere Intraseasonal Stratosphere‐troposphere Coupling
Authors: Saggioro Elena , Shepherd Theodore G. 
Published: November 2019

AbstractThe Southern Hemisphere zonal circulation manifests a downward influence of the stratosphere on the troposphere from late spring to early summer. However, the strength and timescale of the connection, given the stratospheric state, have not been explicitly quantified. Here, SH zonal wind reanalysis time series are analyzed with a methodology designed to detect the minimal set of statistical predictors of multiple interacting variables via conditional independence tests. Our results confirm from data that the variability of the stratospheric polar vortex is a predictor of the tropospheric eddy‐driven jet between September and January. The vortex variability explains about 40% of monthly mean jet variability at a lead time of 1 month and can entirely account for the observed jet persistence. Our statistical model can quantitatively connect the multidecadal trends observed in the vortex and jet during the satellite era. This shows how short‐term variability can help understand statistical links in long‐term changes.
The Importance of Greenland in Setting the Northern Preferred Position of the North Atlantic Eddy‐Driven Jet
Authors: White Rachel H. , Hilgenbrink Casey , Sheshadri Aditi 
Published: November 2019

AbstractThe North Atlantic atmospheric eddy‐driven jet exhibits three “preferred positions,” latitudes where the maximum jet speed occurs more frequently than others. Using an atmospheric general circulation model, Whole Atmospheric Community Climate Model, we explore the extent to which different mountain ranges affect the northern preferred position. The latitude of this preferred position changes only when the latitude of Greenland is changed, and the preferred position disappears when Greenland orography is flattened. We propose that “Greenland tip jet events” create the appearance of a northern “preferred position” in the eddy‐driven jet; tip jets are localized zonal jets east of the southern tip of Greenland, created by flow interacting with Greenland orography. In reanalysis data the northern preferred position is strongly associated with tip jet days. A case study with the CAM4 model suggests that biases in the northern preferred position may stem from biases in the position or strength of the climatological eddy‐driven jet.
MMS Observations of Plasma Heating Associated With FTE Growth
Authors: Akhavan‐Tafti M. , Slavin J. A. , Sun W. J. , Le G. , Gershman D. J. 
Published: November 2019

AbstractUpon formation, flux transfer events (FTEs) in the subsolar magnetosheath have been observed to grow in diameter, λ, while convecting along the magnetopause. Plasma pressure has also been found to decrease sub‐adiabatically with increasing λ, indicating the presence of internal plasma acceleration and heating processes. Here, the Magnetospheric Multiscale (MMS) fields and plasma measurements are used to determine the relative roles of parallel electric fields, betatron, and Fermi processes in plasma heating inside an ensemble of 55 subsolar FTEs. Plasma heating is shown asymmetric inside FTEs. Parallel electric fields dominate (>75%) ion and electron heating at the leading edge of FTEs. At the trailing edge, betatron and Fermi processes overtake (>50%), resulting in ion cooling and electron heating, respectively. The observed strong net heatings inside FTEs are proportional to λ−1/2. It is concluded that reconnection‐driven heating continues inside FTEs far from the subsolar electron and ion diffusion regions.