bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedema
Authors: Liu Xuanyu , Yuan Meng , Xiang Qinqin , Chen Wen , Li Zhujun , Chen Jie , Huang Jiuzuo , Yu Nanze , Long Xiao , Zhou Zhou 
Published: September 2020

AbstractLymphedema is a chronic tissue edema that frequently occurs following lymph node resection for cancer treatment, and is characterized by progressive swelling, chronic inflammation, excessive fibrosis and adipose deposition in the affected limbs. We still lack targeted medical therapies for this disease due to the incomplete understanding of the mechanism underlying the pathogenesis. Here, we performed single-cell RNA-seq of 70,209 cells of the stromal vascular fraction (SVF) of subcutaneous adipose tissue from patients with cancer-related lymphedema and healthy donors. Unbiased clustering revealed 21 cell clusters, which were assigned to 10 cell lineages. One of the four ASC subpopulations, c3, was significantly expanded in lymphedema, which may be related to the fibrosis and pathologic mineralization of adipose tissues in lymphedema. Dysregulated pathways and genes of ASCs in lymphedema were identified through gene set enrichment analysis and differential regulatory network analysis, which reflect the pathophysiological changes in ASCs in lymphedema: enhanced fibrosis, mineralization and proliferation as well as compromised immunosuppression capacity. In addition, we characterized the three subpopulations of macrophages, and found that the adipose tissue of lymphedema displayed immunological dysfunction characterized by a striking depletion of anti-inflammatory macrophages, i.e.,LYVE+resident-like macrophages. Cell-cell communication analysis revealed a perivascular ligand-receptor interaction module among ASCs, macrophages and vascular endothelial cells in adipose tissue. Communication changes for ASCs in lymphedema were identified. For example, PDGFD-PDGFR complex interactions were significantly enhanced between a number of lineages and ASCs, reflecting the role of PDGFD signaling in the pathophysiological changes in ASCs. Finally, we mapped the previously reported candidate genes predisposing to cancer-related lymphedema to cell subpopulations in the SVF, and found thatGJC2, the most likely causal gene was highly expressed in the lymphedema-associated ASC subpopulation c3. In summary, we provided the first comprehensive analysis of cellular heterogeneity, lineage-specific regulatory changes and intercellular communication alterations of the SVF in adipose tissues from cancer-related lymphedema at a single-cell resolution. The lymphedema-associated cell subpopulations and dysregulated pathways may serve as potential targets for medical therapies. Our large-scale dataset constitutes a valuable resource for further investigations of the mechanism of cancer-related lymphedema.
Genome-Wide Asymptomatic B-Cell, CD4+and CD8+T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus Vaccines
Authors: Prakash Swayam , Srivastava Ruchi , Coulon Pierre-Gregoire , Dhanushkodi Nisha R. , Chentoufi Aziz A. , Tifrea Delia F. , Edwards Robert A. , Figueroa Cesar J. , Schubl Sebastian D. , Hsieh Lanny , Buchmeier Michael J. , Bouziane Mohammed , Nesburn Anthony B. , Kuppermann Baruch D. , BenMohamed Lbachir 
Published: September 2020

ABSTRACTOver the last two decades, there have been three deadly human outbreaks of Coronaviruses (CoVs) caused by emerging zoonotic CoVs: SARS-CoV, MERS-CoV, and the latest highly transmissible and deadly SARS-CoV-2, which has caused the current COVID-19 global pandemic. All three deadly CoVs originated from bats, the natural hosts, and transmitted to humansviavarious intermediate animal reservoirs. Because there is currently no universal pan-Coronavirus vaccine available, two worst-case scenarios remain highly possible: (1) SARS-CoV-2 mutates and transforms into a seasonal “flu-like” global pandemic; and/or (2) Other global COVID-like pandemics will emerge in the coming years, caused by yet another spillover of an unknown zoonotic bat-derived SARS-like Coronavirus (SL-CoV) into an unvaccinated human population. Determining the antigen and epitope landscapes that are conserved among human and animal Coronaviruses as well as the repertoire, phenotype and function of B cells and CD4+and CD8+T cells that correlate with resistance seen in asymptomatic COVID-19 patients should inform in the development of pan-Coronavirus vaccines1. In the present study, using several immuno-informatics and sequence alignment approaches, we identified several human B-cell, CD4+and CD8+T cell epitopes that are highly conserved in: (i) greater than 81,000 SARS-CoV-2 human strains identified to date in 190 countries on six continents; (ii) six circulating CoVs that caused previous human outbreaks of the “Common Cold”; (iii) five SL-CoVs isolated from bats; (iv) five SL-CoV isolated from pangolins; (v) three SL-CoVs isolated from Civet Cats; and (vi) four MERS strains isolated from camels. Furthermore, we identified cross-reactive asymptomatic epitopes that: (i) recalled B cell, CD4+and CD8+T cell responses from both asymptomatic COVID-19 patients and healthy individuals who were never exposed to SARS-CoV-2; and (ii) induced strong B cell and T cell responses in “humanized” Human Leukocyte Antigen (HLA)-DR/HLA-A*02:01 double transgenic mice. The findings herein pave the way to develop a pre-emptive multi-epitope pan-Coronavirus vaccine to protect against past, current, and potential future outbreaks.
Divergent selection on behavioral and chemical traits contributes to isolation between populations ofDrosophila melanogaster
Authors: Jin Bozhou , Barbash Daniel A. , Castillo Dean M 
Published: September 2020

AbstractSpeciation is driven by traits that can act to prohibit mating between nascent lineages, including male courtship and female preference for male traits. Mating barriers involving these traits evolve quickly because there is strong selection on males and females to maximize reproductive success, and the tight co-evolution of mating interactions can lead to rapid diversification of sexual behavior. Using lineages ofD. melanogasterthat show strong asymmetrical reproductive isolation, we ask two key questions: which specific male traits are females selecting, and are these traits under divergent sexual selection? These questions have proven extremely challenging to answer, because even in closely related lineages males often differ in multiple traits related to mating behavior. We address these questions by estimating selection gradients for male courtship and cuticular hydrocarbons for two different female genotypes. We identify specific behaviors and particular cuticular hydrocarbons that are under divergent sexual selection and likely contribute to reproductive isolation. Additionally, we discovered that a subset of these traits are plastic; males adjust these traits based on the identity of the female genotype they interact with. These results suggest that even when male courtship is not fixed between lineages, ongoing selection can contribute to reproductive isolation.
The impact of collective brand personification on happiness and brand loyalty
Authors: Braxton Dominique , Lau-Gesk Loraine 
Published: September 2020

Purpose
Frontline service providers are a key touchpoint in a customer’s overall experience with a brand. Though they are recognized as important contributors to brand experiences, service providers have received relatively little attention in both experienced marketing and branding research. This paper aims to illuminate the importance of understanding factors that contribute to the role services providers play within the environmental context of the customer’s brand journey.

Design/methodology/approach
This study uses two experimental studies to show that greater customer happiness and customer loyalty could be achieved through collective brand personification whereby the frontline service provider’s identity and core values align with those of the brand persona and store environment.

Findings
Specifically, findings reveal that customer happiness increases because of feelings of belongingness and greater brand authenticity when the service provider aligns with the retailer’s brand persona and store environment.

Research limitations/implications
While this study gets us closer to understanding how managers can leverage human capital in the retail service environment, there are opportunities to further explore issues such as the impact of collective brand personification on the employee.

Practical implications
Given the strong desire companies have to bolster customer happiness to increase brand loyalty, the findings bolster the importance of understanding the influential factors associated with frontline service providers. Their role in creating optimal customer experiences should not be underestimated.

Social implications
As an important cautionary note, firms should take care when creating the appearance and personality-based occupational qualifications by considering social norms and the impact on societal well-being (e.g. self-consciousness and exclusion can lead to serious illnesses and including depression). Study shows that people have an inherent need to feel accepted and belong to social groups that help to construct and affirm their self-concept, and appreciate opportunities that empower them to seize control against exclusion. Therefore, appearance and personality-based occupational qualifications should be strategically aligned with the image and goals of the firm, and not subject to management bias from an unconscious reaction to an applicant’s physical and interpersonal presentation.

Originality/value
The present study builds on both customer experience and branding literature by examining the relationship between customer happiness and collective brand personification – where the frontline service provider’s identity and core values align with those of the brand. Two experiments test the hypotheses that customer happiness increases because of feelings of belongingness with the brand and the consumer’s perception of the brand’s authenticity when the customer service provider aligns with the brand’s identity and core values.
Research on the influence of product differentiation and emission reduction policy on CO2emissions of China’s iron and steel industry
Authors: Duan Ye , Han Zenglin , Mu Hailin 
Published: September 2020

PurposeThere are certain differences in the production products of enterprises. What are the impacts of product differentiation on the iron and steel industry? Based on the macro background of CO2emission reduction, this paper aims to analyze the economic benefits and environmental changes of the iron and steel industry under the dual influence of CO2emission reduction policy and product differentiation policy.Design/methodology/approachTaking the basic data of iron and steel industry in six regions of China as an example, this paper constructed an extended two-stage dynamic game model to analyze the impact of product differentiation and carbon tax policy on the production, economic indicators and CO2emission levels for the overall industry and regional enterprises.FindingsAs the CO2emission reduction target increased, the unit carbon tax and total tax increased, whereas the macro-environmental losses, social welfare, consumer surplus and outputs decrease. Emission reduction pressures and other economic indicators showed obvious regional differences. Differentiated products promoted various indicators of enterprises and industries; higher degrees of product differentiation resulted in greater promoting effects on economic indicators.Originality/valueThis paper constructed multiple emission reduction and production backgrounds, and discusses the impact of the comprehensive implementation of these policies, which has been practically absent in previous studies. The results of this study are consistent with the current industrial policy for stable production and environmental protection, and also provides a reference for the formulation of detailed policies in the future.
Airbnb and hotels: friends, enemies or frenemies?
Authors: Mhlanga Oswald 
Published: September 2020

Purpose
The purpose of this paper is to explore the intricate relationship between the flagship of the sharing economy, Airbnb and hotel revenue per available room (RevPAR) in South Africa.

Design/methodology/approach
To identify the impact of Airbnb on hotel RevPAR, the paper used a triple difference-in-differences framework that compares changes in cities in South Africa where Airbnb started operating relative to areas without Airbnb. A total of 569 hotels were analysed.

Findings
While the study finds no evidence of adverse impacts of Airbnb on hotel RevPAR, the findings show that the entry of Airbnb led to a decrease in RevPAR of budget hotels. However, its impact is more pronounced during periods of peak demand, consequently, disrupting the pricing power of hotels.

Research limitations/implications
The research was based on the impact of Airbnb on hotel RevPAR in hotels situated in specific cities in South Africa. Caution is therefore required when generalising the findings of this study to other hotels in other geographic areas. Moreover, if a longer time series data set of hotels in the post-Airbnb time period could become available, it would be interesting to further investigate the time-varying dynamic effects of Airbnb on hotel RevPAR. However, the findings underscore the notion that innovations are not intrinsically disruptive but only relative to another product. In so doing, the study adds to the limited body of work in the field on disruptive innovation and to the academic discourse on innovation in tourism more broadly.

Practical implications
First, the findings suggest the impact on hotels tends towards Airbnb generally playing a largely complementary role rather than a diversionary one. However, to increase RevPAR, hotels should systematically change their pricing models to account for flexible capacity by rethinking the wisdom of seasonal pricing and reduce prices during peak seasons to avoid inviting more competition from Airbnb.

Originality/value
To the best of the author’s knowledge, this paper is the first to explore the relationship between Airbnb and hotel markets using a triple difference methodology.
A framework for quality assurance for archives and records management education in an open distance e-learning environment in Eswatini
Authors: Tsabedze Vusi , Ngoepe Mpho 
Published: September 2020

PurposeThe purpose of this study is to examine quality assurance for archives and records management (ARM) education in an open distance e-learning (ODeL) environment in Eswatini with a view to conceptualise a framework for quality assurance in the development and implementation of an ARM programme in the context of ODeL.Design/methodology/approachThe study is anchored on the interpretive research paradigm, which surrounds a systematic literature review. The researcher searched for literature online, using scientific databases such as Ebsco, Scopus and Google Scholar. The search applied the publications from 2005 to 2019. The main search keywords are “archives”, “records management”, “open distance e-learning” and “quality assurance”. A total of 15 articles, which included documents, journal articles, reports, web pages and monographs, were retrieved, reviewed and analysed in this study. This conceptual study was preliminary, and the researcher hopes that further empirical studies based on the findings of this study could be pursued in future.FindingsARM as a form of study and delivered on ODeL platforms have been proposed in Eswatini. The major concern among stakeholders is how to ensure the quality of such programmes.Research limitations/implicationsThis conceptual study was preliminary, and the researcher hopes that further empirical studies based on the findings of this study could be pursued in future.Practical implicationsThe findings and recommendations will help in the development of ARM programmes to be offered effectively by way of ODeL, there is a need to develop a transparent quality assurance framework for such an application and its implementation.Originality/valueThis is the first study on quality assurance for ARM education in an ODeL environment in Eswatini. As part of the study, a quality assurance framework was designed for the implementation of ARM education on an ODeL platform. This quality assurance framework is intended to help higher education institutions in Eswatini such as the University of Eswatini as well as stakeholders such as the Eswatini National Archives and others to design ARM education and deliver it on an ODeL platform in a manner that guarantees adequate quality.
Rethinking and reinventing learning, education and collaboration in the digital age—from creating technologies to transforming cultures
Authors: Fischer Gerhard , Lundin Johan , Lindberg J. Ola 
Published: September 2020

PurposeThe digitalization of society results in challenges and opportunities for learning and education. This paper describes exemplary transformations from current to future practices. It illustrates multi-dimensional aspects of learning which complement and transcend current frameworks of learning focused on schools. While digital technologies are necessary for these transformations, they are not sufficient. The paper briefly illustrates the applicability of the conceptual framework to the COVID-19 pandemic. It concludes that design opportunities and design trade-offs in relation to digital technologies and learning should be explored by envisioning the cultural transformation that are desirable for making learning a part of life.Design/methodology/approachThis paper is based on the work conducted at the symposium “Rethinking and Reinventing Learning, Education, and Collaboration in the Digital Age—From Creating Technologies to Transforming Cultures” that took place in Engeltofta outside of Gävle, Sweden in September 2019. The symposium invited scholars in collaborative analysis of design opportunities and design trade-offs in relation to digital technologies and learning and explored design strategies for systematically and proactively increasing digital technology's contributions to learning and collaborating. The paper first provides a condensed introduction of a conceptual framework summarizing current practices, their problems and promising alternatives. Multi-dimensional aspects of learning and lifelong learning will be briefly described as promising future alternatives to school learning. Examples of transformative practices are supporting the major argument of the paper that creating new technologies is an important prerequisite to address the fundamental challenge of transforming cultures. The unanticipated but fundamental event of the occurrence of COVID-19 will be briefly described to provide further evidence for the need and the applicability of our conceptual framework for rethinking and reinventing learning, education and collaboration in the digital age.FindingsThe paper provides a condensed introduction of a conceptual framework summarizing current practices, their problems and promising alternatives. The framework includes multi-dimensional aspects of learning and lifelong learning as a promising future alternative to a focus on school learning.Originality/valueThis paper describes exemplary transformations from current to future practices. It illustrates multi-dimensional aspects of learning which complement and transcend current frameworks of learning focused on schools.
General public’s attitude toward governments implementing digital contact tracing to curb COVID-19 – a study based on natural language processing
Authors: S.V. Praveen , Ittamalla Rajesh 
Published: September 2020

Purpose
Governments worldwide are taking various measures to prevent the spreading of COVID virus. One such effort is digital contact tracing. However, the aspect of digital contact tracing was met with criticism, as many critics view this as an attempt of the government to control people and a fundamental breach of privacy. Using machine learning techniques, this study aims to deal with understanding the general public’s emotions toward contact tracing and determining whether there is a change in the attitude of the general public toward digital contact tracing in various months of crises. This study also analyzes the significant concerns voiced out by the general public regarding digital contact tracing.

Design/methodology/approach
For the analysis, data were collected from Reddit. Reddit posts discussing the digital contact tracing during COVID-19 crises were collected from February 2020 to July 2020. A total of 5,025 original Reddit posts were used for this study. Natural language processing, which is a part of machine learning, was used for this study to understand the sentiments of the general public about contact tracing. Latent Dirichlet allocation was used to understand the significant issues voiced out by the general public while discussing contact tracing.

Findings
This study was conducted in two parts. Study 1 results show that the percentage of general public viewing the aspect of contact tracing positively had not changed throughout the time period of Data frame (March 2020 to July 2020). However, compared to the initial month of the crises, the later months saw a considerable increase in negative sentiments and a decrease in neutral sentiments regarding the digital contact tracing. Study 2 finds out the significant issues public voices out in their negative sentiments are a violation of privacy, fear of safety and lack of trust in government.

Originality/value
Although numerous studies were conducted on how to implement contact tracing effectively, to the best of the authors’ knowledge, this is the first study conducted with an objective of understanding the general public’s perception of contact tracing.
Study of the psychometric properties and population norms of the C-SHARP in a representative French population
Authors: Oubrahim Leïla , Combalbert Nicolas 
Published: September 2020

Purpose
To fill this gap, this paper aims to translate the children’s scale of hostility and aggression: reactive/proactive (C-SHARP) into French and then tested its psychometric properties and established the first French standards.

Design/methodology/approach
This paper assess the aggressive behavior of 305 children and adolescents with intellectual disability (ID). This paper tested the scale’s factor structure (confirmatory factor analysis), internal consistency and inter-rater reliability.

Findings
The results support a factor structure similar to the US version. Factor analysis yielded a five-factor solution, namely, verbal aggression (12 items), bullying (12 items), covert aggression (11 items), hostility (9 items) and physical aggression (8 items). The French-speaking version of the C-SHARP shows good reliability (internal consistency) and good inter-rater reliability. The French version demonstrated encouraging evidence of validity. This paper also established French norms that were similar to US norms. This paper concludes that the French-speaking version of the C-SHARP must benefit from additional psychometric analyzes to confirm its adaptation for research and the clinic.

Originality/value
There is no tool currently available in France for the evaluation of aggressive behavior in children and adolescents with ID. The C-SHARP (Farmer and Aman, 2009) is the only questionnaire that specifically assesses aggression in children and adolescents with ID, its form, frequency and its proactive or reactive qualities. The French version of the C-SHARP could be a useful diagnostic tool to assess aggressive behavior in children and adolescents with ID and to identify and set up appropriate support strategies.