bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influences of prompted voiding for urinary incontinence among older people in nursing homes
Authors: Siswoyo  , Lestari Cicik , Susanto Tantut , Rasni Hanny , Hakam Mulia , Ridla Ahmad Zainur 
Published: December 2020

AbstractResearch question: What are the influences of prompted voiding (PV) for urinary incontinence (UI) among older people in nursing homes? Research problem: This study aims to evaluate the effects of PV for UI of older people's subjects in nursing homes. Management of UI among older people is needed to overcome the possibility of new problem for older people. A randomized controlled study was performed of pre‐test post‐test design for 12 subjects (6 of control and 6 of intervention group). An intervention group followed PV instructions for 24 hours during 28 days, while the control group was instructed to urinate in toilet or to use diapers. Outcome variables were measured using incontinence severity index (ISI). There was statistically significant main effect across ISI among intervention group pre‐ (8.67 ± 1.97) and post‐ (6.67 ± 2.73) intervention of PV (P = .007). While there was statistically significant differenced ISI between control and intervention group (9.67 ± 1.86 vs 6.67 ± 2.73) post‐intervention of PV (P = .005). There was higher reduced ISI in the intervention group (∆M −2.00 ± 1.09) after 28 days of PV (P = .001). PV could be used to increase the older people's initiative to go to toilet and decrease incontinence episodes during a short time by their self in the nursing home.
Access to and exclusion from housing over time: Refugees' experiences in rural areas
Authors: Weidinger Tobias , Kordel Stefan 
Published: December 2020

AbstractTaking the example of recognized refugees in rural Germany, and following the housing pathways approach, the paper addresses the complex interplay of individual and family‐related residential preferences over time as well as structural factors regarding access to housing and associated settlement and integration. Results are from a long‐term empirical study that encompassed both refugees’ and local actors’ views. Mechanisms and practices of exclusion that prevent refugees from accessing appropriate private housing are related to the negotiation of residential preferences about where and how to live, as well as to structural aspects such as the pattern of local housing markets, accessibility of infrastructures or the unwillingness of landlords to let to refugees. The paper concludes to highlight the role of place in housing trajectories and the significance of social resources within refugees' practices and local intermediaries' strategies to overcome exclusion and provision of access to rural housing.
NLR in eXile: Emerging roles of NLRX1 in immunity and human disease
Authors: Pickering Robert J. , Booty Lee M. 
Published: December 2020

SummaryNLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its NLR counterparts with unique features that mediate atypical functions compared with traditional NOD‐like receptors (NLRs). Aside from a mitochondrial targeting sequence, the N‐terminal region is yet to be characterized. Mitochondrially located, NLRX1 sits within a subgroup of regulatory NLRs responsible for negatively regulating cellular inflammatory signalling. As well as modulating pathogen response, emerging evidence is implicating NLRX1 as a central homeostatic gatekeeper between mitochondrial biology and immunological response. More recently, NLRX1 has been implicated in a wide range of disease, both pathogen‐driven and otherwise. Emerging links of NLRX1 in cancer biology, autoimmunity and other inflammatory conditions are raising the potential of targeting NLRX1 therapeutically, with recent studies in inflammatory bowel disease showing great promise. Within this review, we address the unique features of NLRX1, its roles in innate immune signalling and its involvement in a range of inflammatory, metabolic and oncology disease indications with a focus on areas that could benefit from therapeutic targeting of NLRX1.
Update on the role of antiseptics in the management of chronic wounds with critical colonisation and/or biofilm
Authors: Alves Paulo J. , Barreto Ruben T. , Barrois Brigitte M. , Gryson Luc G. , Meaume Sylvie , Monstrey Stan J. 
Published: December 2020

AbstractBiofilms play a major role in delaying chronic wounds from healing. A wound infiltrated with biofilm, or “critically colonised” wound, may become clinically infected if the number of microbes exceeds a critical level. Chronic wound biofilms represent a significant treatment challenge by demonstrating recalcitrance towards antimicrobial agents. However, a “window of opportunity” may exist after wound debridement when biofilms are more susceptible to topical antiseptics. Here, we discuss the role of antiseptics in the management of chronic wounds and biofilm, focusing on povidone‐iodine (PVP‐I) in comparison with two commonly used antiseptics: polyhexanide (PHMB) and silver. This article is based on the literature reviewed during a focus group meeting on antiseptics in wound care and biofilm management, and on a PubMed search conducted in March 2020. Compared with PHMB and silver, PVP‐I has a broader spectrum of antimicrobial activity, potent antibiofilm efficacy, no acquired bacterial resistance or cross‐resistance, low cytotoxicity, good tolerability, and an ability to promote wound healing. PVP‐I represents a viable therapeutic option in wound care and biofilm management, with the potential to treat biofilm‐infiltrated, critically colonised wounds. We propose a practical algorithm to guide the management of chronic, non‐healing wounds due to critical colonisation or biofilm, using PVP‐I.
Theory of heat stress management: Development and application in the operating room
Authors: Byrne Jill , Ludington‐Hoe Susan M. 
Published: December 2020

AbstractAimThe Theory of Heat Stress Management addresses the phenomenon of occupational heat stress and applies the theory to surgical staff wearing personal protective equipment while performing surgery. This discussion paper relates development of the prescriptive middle range theory of heat stress management to inform and advance research and provide evidence to support new standards of care in clinical nursing practice.DesignThe prescriptive middle range theory was developed by summarizing essential elements of the theory, describing the linkages among the dimensions of the theory, enumerating nursing interventions and physiological, psychological and cognitive outcomes, stating relevant assumptions, defining and identifying relationships between the concepts of heat stress management in observable and measurable terms.Data SourcesThis discussion paper is based on the first author's experiences with occupational heat stress, observed improvements in surgical personnel's thermal comfort by using a cooling intervention and knowledge gained from an extensive integrated literature review and ongoing clinical research.Implications for nursingThe middle range theory was developed to create awareness of the impact heat stress has on the health and well‐being of all healthcare personnel at risk for heat stress due to wearing personal protective equipment. Nurses need to recognize individuals in thermally stressful environments, evaluate and monitor individuals’ physiological and psychological responses and promote comfort by providing interventions to alleviate occupational heat stress.ConclusionThe Theory of Heat Stress Management combines dimensions specific to heat stress affecting surgical staff and provides a perspective that facilitates knowledge development, can enhance nursing practice and support exploration of the linkages and prescriptions of the theory through research.ImpactThe predictive middle‐range Theory of Heat Stress Management will guide nurses to promote the health and well‐being of healthcare workers and influence and improve clinical nursing practice, education, and research related to heat stress management.
The relationship between work‐life balance, the need for achievement, and intention to leave: Mixed‐method study
Authors: Dousin Oscar , Collins Ngan , Bartram Timothy , Stanton Pauline 
Published: December 2020

AbstractAimsTo examine the mediating role of employee well‐being on the relationship between work‐life balance practices, the need for achievement and intention to leave among nurses in Malaysia.BackgroundWork‐life balance practices are associated with employee perceptions of the need for achievement and well‐being which subsequently influence their intention to leave the organization. This study contributes new knowledge to nursing studies on work‐life balance in an Asian and Islamic society where the expectations for women are to focus on family rather than career.DesignA cross‐sectional, explanatory mixed methodology.MethodsThis is a two‐phase study conducted between 2015–2017 with 401 nurses in East Malaysia. In Phase 1, researchers surveyed 379 nurses to test eight hypotheses and in Phase 2 researchers interviewed 22 nurses to explore the results of Phase 1.ResultsPhase 1 revealed job satisfaction mediates the relationship between work‐life balance practices (e.g. flexibility and choice in working hours, supportive supervision), financial success, and intention to leave. However, life satisfaction and money as a motivator did not mediate such relationships. Phase 2 identified four important factors that cast light on survey results: working conditions of Malaysian nurses; inadequate compensation in the public healthcare sector; team‐based practices; and pressure on senior nurses in both administrative and clinical roles.ConclusionThis is one of the first studies to investigate work‐life balance issues among nurses in Malaysia. Outcomes of this study extend the debates on work‐life balance and employee well‐being in an Asian Islamic social context.ImpactThe use of flexible working arrangements and collectivist teamwork approaches, improving compensation and employment benefits and eliminating the ‘time‐based job promotion’ policy may help to mitigate work‐life balance issues and intention to leave among nurses in Malaysia.
Epigean and hypogean drivers of Neotropical subterranean communities
Authors: Mendes Rabelo Lucas , Souza‐Silva Marconi , Lopes Ferreira Rodrigo 
Published: December 2020

AbstractAimIn addition to cave size and other subterranean habitat characteristics, cave entrances are important structurers of neotropical cave communities. However, little is known about the epigean ecosystems factors that might dictate the influence of entrances and the relationship among surface and cave communities, as entrance regions are ecotonal zones between the epigean and hypogean ecosystems. We aimed to assess the influence of epigean and hypogean factors as potential drivers of invertebrate species richness in Neotropical caves as well as the influence of the regional pool of invertebrate diversity on cave invertebrate diversity.LocationLimestone caves in south‐eastern Brazil.TaxonInvertebratesMethodsData were collected in 48 caves within the Cerrado biome (Brazilian Savanna). The fauna sampling was performed by a direct intuitive search (DIS). Landscape characteristics and climatic parameters were accessed using geographic information systems. The characterization of the caves occurred during each sampling event. Regional diversity was based on the Taxonomic Catalog of Brazilian Fauna. To clarify the factors that significantly influence invertebrate species richness of the caves, we used generalized linear models (GLM). The relationship between regional diversity and cave diversity was evaluated based on linear models (LM).ResultsOverall, 1,173 species were found, of which 72 were obligate subterranean dwellers. The cave total species richness was influenced by hypogean factors and epigean factors. The species richness of obligate cave dwellers was significantly explained only by cave size. The regional pool of invertebrate species influenced the levels of biodiversity in the studied caves. The taxa with troglobitic species tended to be more diverse in caves than expected.Main conclusionsIn addition to the influences of intrinsic cave variables, we highlight the importance of epigean factors on subterranean diversity in the Neotropics. The study shows the significant influence of the regional species pool on cave faunal composition. These findings reinforce the importance of considering the surrounding areas in actions regarding cave biodiversity conservation.
RAD51AP1 promotes progression of ovarian cancer via TGF‐β/Smad signalling pathway
Authors: Zhao Hongyu , Gao Yan , Chen Qi , Li Jie , Ren Meng , Zhao Xiaoting , Yue Wentao 
Published: December 2020

AbstractOvarian cancer (OC) is one of the leading causes of female deaths. However, the molecular pathogenesis of OC has still remained elusive. This study aimed to explore the potential genes associated with the progression of OC. In the current study, 3 data sets of OC were downloaded from the GEO database to identify hub gene. Somatic mutation data obtained from TCGA were used to analyse the mutation. Immune cells were used to estimate effect of the hub gene to the tumour microenvironment. RNA‐seq and clinical data of OC patients retrieved from TCGA were used to investigate the diagnostic and prognostic values of hub gene. A series of in vitro assays were performed to indicate the function of hub gene and its possible mechanisms in OC. As a result, RAD51AP1 was found as a hub gene, which expression higher was mainly associated with poor survival in OC patients. Up‐regulation of RAD51AP1 was closely associated with mutations. RAD51AP1 up‐regulation accompanied by accumulated Th2 cells, but reduced CD4 + T cells and CD8 + T cells. Nomogram demonstrated RAD51AP1 increased the accuracy of the model. Down‐regulation of RAD51AP1 suppressed proliferation, migration and invasion capabilities of OC cells in vitro. Additionally, scatter plots showed that RAD51AP1 was positively correlated with genes in TGF‐β/Smad pathway. The above‐mentioned results were validated by RT‐qPCR and Western blotting. In conclusion, up‐regulation of RAD51AP1 was closely associated with mutations in OC. RAD51AP1 might represent an indicator for predicting OS of OC patients. Besides, RAD51AP1 might accelerate progression of OC by TGF‐β/Smad signalling pathway.
Feature selection, artificial neural network prediction and experimental testing for predicting breakage rate of maize kernels based on mechanical properties
Authors: Xia Guoyi , Xu Yang , Su Yuan , Gao Xiaojun , Li Yibo , Qiao Mengmeng , Yu Yingbo 
Published: December 2020

AbstractThe kernel breakage in harvest process is a significant problem which causes massive grain losses. In order to solve this problem, a possible solution is to predict the breakage rate and give suitable harvest time thus reducing grain losses. This study focused on using mechanical properties to predict breakage rate. Compression tests, compression–relaxation tests, insertion–retraction and stretch tests were conducted and 20 parameters were derived. Threshing tests were conducted to get breakage rate. As these parameters might be related and it is not practical to use massive parameters for prediction, the feature selection using neighborhood component analysis (FSNCA) was used for picking important parameters. The variables were compacted to an acceptable level by the FSNCA while various aspects of mechanical properties were included. The FSNCA determined the hardness of floury endosperm, rupture energy in vertical direction (x‐axis), allowable stress in lateral direction (z‐axis), hysteresis in x‐axis and elastic modulus in z‐axis as predictors. The artificial neural network (ANN) was built for prediction. The built ANN model showed an agreement in prediction results and real breakage rate (R= 0.98). The prediction error was ±1.7%.Practical ApplicationsThe mechanical properties were illustrated as potential indexes which can be utilized for predicting breakage rate of maize kernels in threshing process. The selection method reduced the dimension of predictors, which means fewer tests are required for prediction. As a result, this research proposed a possible solution for the prediction of maize breakage in harvest. Moreover, the prediction model can give guidance for optimal harvest time and thus reduce breakage rate in harvest.
Misrepresentation of contraceptive effectiveness rates for fertility awareness methods of family planning
Authors: Turner Joseph V. 
Published: December 2020

AbstractAimSimplified contraceptive method‐efficacy and/or typical‐use effectiveness rates are commonly used for direct comparison of the various contraceptive methods. Use of such effectiveness rates in this manner is, however, problematic in relation to the fertility awareness methods (FAMs). The aim of this review is to critically examine current international representation of contraceptive effectiveness for the various FAMs in clinical use. This review also details important issues when appraising and interpreting studies on FAMs used for avoiding pregnancy.MethodsCurrent international literature regarding contraceptive effectiveness of FAMs was surveyed and appraised. This included World Health Organization and Centers for Disease Control (USA) resources, key clinical studies and recent systematic reviews. Chinese literature was also searched, since these data have not been reported in the English literature.ResultsReliance on certain historical studies has led to the misrepresentation of contraceptive effectiveness of FAMs by perpetuation of inaccurate figures in clinical guidelines, the international literature and the public domain.Interpretation of published study results for FAMs is difficult due to variability in study methodology and other clinical trial quality issues. Recent systematic analyses have noted the considerable issues with study designs and limitations.Several non‐English published studies using the Billings Ovulation Method have demonstrated that a broader review of the literature is required to better capture the data potentially available.ConclusionA deeper understanding by clinicians and the public of the applicability of contraceptive effectiveness rates of the various FAMs is needed, instead of reliance on the inaccurate conglomerate figures that are widely presented.
Topical photodynamic therapy in the treatment of benign oral mucosal lesions: A systematic review
Authors: Romano Antonio , Di Stasio Dario , Lauritano Dorina , Lajolo Carlo , Fiori Fausto , Gentile Enrica , Lucchese Alberta 
Published: December 2020

AbstractBackgroundThe introduction of photodynamic therapy (PDT) in various branches of the dental field such as endodontics, implantology, periodontology, and restorative dentistry and oral medicine has become useful in recent decades. This systematic review presents an overview of the literature to evaluate the usefulness of topical PDT for the treatment of benign oral soft tissue lesions and to identify limitations in prior studies to improve PDT applications.MethodsWe performed a review of the literature using different search engines (PubMed, ISI Web of Science, and the Cochrane Library) employing MeSH terms such as "Photodynamic therapy" and "PDT" in conjunction with other terms. We utilized the Population, Intervention, Comparison, Outcomes, and Study design (PICOS) method to define our study eligibility criteria.ResultsInitial results were 1513. Finally, there were only 21 studies that met our selection criteria. We divided the 21 selected items into two groups: inflammatory diseases and infective diseases.ConclusionsAlthough topical PDT is an easy to perform and well‐tolerated treatment and appears to be a valid method with promising results in the treatment of benign lesions of the oral cavity's soft tissues, further studies are needed to complete the current knowledge of this technique.
Perception of traditional foods in societies in transition: The maize tortilla in Mexico
Authors: Sánchez‐Vega Laura P. , Espinoza‐Ortega Angélica , Thomé‐Ortiz Humberto , Moctezuma‐Pérez Sergio 
Published: December 2020

AbstractSocial and urban transformations have changed the ways of elaboration of traditional foods. Maize tortilla, the base of the Mexican diet, has experienced these transformations; nevertheless, in spite of being an emblematic food in Mexico, little is known about the perceptions by urban consumers. The aim was to analyze the perceptions about tortilla in urban consumers from three contrasting socioeconomic regions. A questionnaire was applied in some cities of northern, central, and southern Mexico to 1,156 consumers. A free word association technique was used as response to the word “tortilla”. Nineteen categories were grouped in 10 dimensions. Results showed there is a sense of national identity regarding maize tortilla; however, coexistence of postmodern and traditional perception is observed. Perception differed by zone according to sociocultural, historical and economic development. In the face of modernizing changes, consumers adopt new perceptions on traditional foods as is happening in many societies in developing countries.Practical applicationsPerceptions are related to sociocultural, historic and economic aspects. In modernizing processes, consumers adapt new perceptions about traditional foods. The associations with the maize tortilla, staple in the Mexican diet, showed several symbolic elements of the daily life of Mexicans. There is a sense of national identity towards tortilla, differentiated by zone. Understanding the perceptions by age and gender and zone of study, can be used to generate marketing strategies and public policy that favoring the development of rural areas and local economies towards traditional foods, as elements that enhance regional or local development.
Communication during the initial visit to a CPAP clinic Practitioners’ experiences of facilitators and barriers when talking to patients with obstructive sleep apnea
Authors: Broström Anders , Fridlund Bengt , Fossum Bjöörn , Pakpour Amir , Nilsen Per , Ulander Martin 
Published: December 2020

SummaryAdherence to continuous positive airway pressure treatment for obstructive sleep apnea tends to be poor. Communication influences adherence but has not previously been investigated from a practitioner perspective, although shared decision‐making is known to be of great importance. The aim was to describe how practitioners experience communication with patients with obstructive sleep apnea during the initial visit at a continuous positive airway pressure treatment clinic, with focus on facilitators and barriers related to the 4 Habits Model, a communication model comprised of four types of interrelated skills to make encounters more patient‐centred: investing in the beginning; exploring the patient perspective; showing empathy; and investing in the end. A descriptive design with qualitative content analysis was used. A deductive analysis was carried out based on interviews with 24 strategically selected practitioners from seven continuous positive airway pressure treatment clinics. The 4 Habits Model was used as a framework for identifying facilitators and barriers to communication. Investments in the beginning was described as creating contact, showing the agenda and being adaptive, while explore the patient perspective included showing awareness, being explorative and creating a participating climate. Show empathy consisted of showing openness, being confirmative and creating acceptance, while showing a structured follow‐up plan, being open minded and invitational and creating motivation to build on were descriptions of invest in the end. Awareness of potential facilitators and barriers for patient‐centred communication during the beginning, middle and end of a continuous positive airway pressure treatment consultation can be used to improve contextual conditions and personal communication competences among practitioners working with continuous positive airway pressure treatment initiation.