bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deploying Plural Drug Policies after the ‘War on Drugs’: A Geographical Perspective
Authors: Hall Tim 
Published: December 2019

Abstract
There is a growing consensus that acknowledges the failings of the prohibitionist ‘war on drugs’ model of international drug policy. Concomitant drug policy reform literatures have been characterized by the advocacy of policy pluralism, experimentation, evidence gathering/evaluation and the avoidance of drug fetishization. This paper builds upon these literatures and explores some of the complexities of drug policy pluralization, including challenges associated with drug policy asymmetries and repatriation and the, largely unexplored, potentials of deploying drug policies in combination. It argues that the drug policy reform literature has tended to favour evaluation of policy alternatives over discussion of their geographical deployment under a more plural international policy regime. It considers models to inform the deployment of plural drug policies. Conceptually this paper draws on geographical literatures and attempts to rethink drug markets and drug policy reform in geographically sensitive, regional and relational ways, highlighting scalar and relational challenges to drug policy pluralization. It concludes by outlining an extensive set of research priorities that speak directly to the challenges identified through this geographical lens.
Onset of pituitary hormone deficiencies in optic nerve hypoplasia: a temporal trend analysis of 32 children at Mayo Clinic
Authors: Wadams Heather D. , Gupta Nidhi , Novotny Paul , Tebben Peter J. 
Published: December 2019

Abstract

Background
The objective of this study was to evaluate the age at onset and frequency of individual pituitary hormone deficiencies (PHDs) in optic nerve hypoplasia (ONH).

Methods
We performed a retrospective chart review of patients ≤21 years of age evaluated between 1996 and 2014. Patients were included if they had: (1) ONH diagnosed by an ophthalmologist and/or magnetic resonance imaging (MRI), (2) documentation of pituitary hormone function on at least two separate occasions and (3) at least one PHD documented or a midline abnormality of the brain on MRI.

Results
Thirty-two patients (18 females, 14 males) were included (median age, 8 years [range, 1.1–21.0 years]). All patients had ONH (bilateral, n = 31; unilateral, n = 1) and at least one midline abnormality of the brain. At least one PHD was present in 75% of patients (n = 24). The remaining 25% of patients (n = 8) did not develop any PHD at least until the last follow-up (<2–8.6 years of follow-up), despite the presence of ONH and a midline abnormality of the brain. The median age (years) at diagnosis of antidiuretic hormone (ADH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH) and growth hormone (GH) deficiencies was 0.5, 0.6, 0.7 and 1.6, respectively. Twenty-three percent of all PHDs were identified during the neonatal period, 56% by 12 months and 72% by 36 months of age. The latest age at diagnosis of GH, ACTH and TSH deficiencies was 9.6, 9.9 and 12.6 years, respectively.

Conclusions
The majority of the PHDs in ONH develop within the first 3 years of life. We propose evaluation for endocrinopathies at the time of diagnosis of ONH, with repeat assessment for new deficiencies every 3–4 months until age 3 years and at least semi-annually until growth and puberty are complete.
Verdinglichung und Zerstörung. Günther Anders und der Begriff der Geschichte im Jahr 1941
Authors: Pollmann Anna 
Published: December 2019

Abstract
The article discusses the transformation of the concept of History as it can be traced in the writings of Günther Anders. Anders is primarily known as a critique of modern technology specifically of the atomic bomb, which made him a mentor for the first anti-nuclear movement in West-Germany in the late 1950s. His historical thinking was therefore mainly perceived in its post-historic and apocalyptic dimensions. A closer look at his earlier writings reveals not only that his questioning of the modern concept of History began long before the “ontological cesura” of Hiroshima and Nagasaki. The article discusses two unpublished philosophical manuscripts as well as passages from his Californian diaries, both dating from 1940/41 and focussing the concept of progress. To follow his thoughts from two different angles – historical philosophical inquiry (however fragmented) and the literary form of his diary – gives us insight in his specific methodology of writing coined “Gelegenheitsphilosophie”. This specific form between “journalism and metaphysics” enables Anders to review abstract philosophical concepts on the basis of everyday observation. In the crucial year 1941 Anders reviews progress-thought from the perspective of a Hollywood film studio, raising questions of tradition, authenticity and technological progress in cultural production.
Die Kreatur und Walter Benjamins Periodika-Netzwerk der 20er Jahre. Neue Zugänge der Zeitschriftenforschung
Authors: Frank Gustav 
Published: December 2019

Abstract
Die Publizistik hat erfolgreich ihre Auffassung durchgesetzt, dass „die Diskussion einer wie auch immer gearteten ‚Zeitschriftentheorie‘“ „wenig ergiebig“ sei, woraus sich auch der schmale, auf die Inhaltsanalyse beschränkte Werkzeugkasten der Zeitschriftenforschung erklärt (dazu historisch fundierte Ergänzungsvorschläge unter Abschnitt 9 und 10). Nach einer Einführung in die Zeitschrift Die Kreatur (Abschnitt 1) scheint es deshalb nötig, das theoretische Objekt – Voraussetzung jeglicher Forschungspraxis – ‚Zeitschriften‘ vorab in aller gebotenen Kürze (Abschnitt 2–4) historisch-systematisch zu skizzieren. Die Kreatur kann dann als eine der Zeitschriften im Rahmen zeitgenössischer Format-Optionen (Abschnitt 5–8) in Netzwerken wie dem um Walter Benjamin situiert werden (Abschnitt 11–13).
Ein „Zusammengehen ohne Zusammenkommen“. Der Entstehungsprozess des intellektuellen Netzwerkes um die Zeitschrift Die Kreatur
Authors: Rosso Enrico 
Published: December 2019

Abstract
This research article aims to deliver an analytical representation of the intellectual environment of the culture journal Die Kreatur (1926–1930), a religious-dialogical quarterly edited by Martin Buber, Joseph Wittig, and Viktor von Weizsäcker and enlivened by some of the most prominent figures of German-Jewish interwar culture (among others W. Benjamin, H. S. Bergman, E. Rosenstock-Huessy, F. Rosenzweig, E. Simon, and L. Strauss). Building on a recognition of the problematic relationship between the dialogical model claimed in the programmatic foreword of the journal and the group narratives enacted by its key contributors, the study attempts to outline the formation process of the intellectual plexus of the journal and to provide a differentiated analysis of its singular constituents via a sociologically informed framework. The representation of the intellectual network of Die Kreatur in accordance with the model of a “circle of circles” provides insight into the elusive dialectic of interaction and divergence that determines the relations between the main actors of the journal and thus contributes to unfold the interplay of biographical intersections and conceptual synergies, as well as incongruities, frictions, and contradictory instances that determines its editorial and philosophical profile.
Surface-plasmon-polariton-driven narrow-linewidth magneto-optics in Ni nanodisk arrays
Authors: Freire-Fernández Francisco , Kataja Mikko , van Dijken Sebastiaan 
Published: December 2019

Abstract
The field of magnetoplasmonics exploits interactions between light and magnetic matter at the nanoscale for light manipulation and resonant magneto-optics. One of the great challenges of this field is overcoming optical losses in magnetic metals. Here, we exploit surface plasmon polaritons (SPPs) excited at the interface of an SiO2/Au bilayer to induce strong magneto-optical responses on the Ni nanodisks of a periodic array. Using a reference system made of Au nanodisks, we show that optical losses in Ni hardly broaden the linewidth of SPP-driven magneto-optical signals. Loss mitigation is attained because the free electrons in the Ni nanodisks are driven into forced oscillations away from their plasmon resonance. By varying the SiO2 layer thickness and lattice constant of the Ni nanodisk array, we demonstrate tailoring of intense magneto-optical Kerr effects with a spectral linewidth down to ~25 nm. Our results provide important hints on how to circumvent optical losses and enhance magneto-optical signals via the design of off-resonance magnetoplasmonic driving mechanisms.
Crystal structure of bis(3-chloro-N-(1-(pyrazin-2-yl)ethylidene)benzohydrazonato-k3
N,N′,O)nickel(II), C26H20N8O2Cl2Ni
Authors: Hao Zhen-Li , Huang Cun-Han 
Published: December 2019

Abstract
C26H20N8O2Cl2Ni, orthorhombic, Pbcn (no. 60), a = 11.737(10) Å, b = 9.309(8) Å, c = 23.72(2) Å, V = 2592(4) Å3, Z = 4, R
gt(F) = 0.0361, wR
ref(F
2) = 0.0934, T = 296 K.
Low temperature redetermination of the crystal structure of catena-poly[[tri-4-fluorobenzyltin(IV)]μ2-pyridine-4-carboxylato-κ2
N:O], {C27H22F3NO2Sn}n
Authors: Lo Kong Mun , Lee See Mun , Tiekink Edward R.T. 
Published: December 2019

Abstract
C27H22F3NO2Sn, monoclinic, P21/n (no. 14), a = 8.7913(2) Å, b = 19.0856(5) Å, c = 13.9417(4) Å, β = 91.017(2)°, V = 2338.87(11) Å3, Z = 4, R
gt(F) = 0.0324, wR
ref(F
2) = 0.0873, T = 100(2) K.
Synapses: Multitasking Global Players in the Brain
Authors: Lübke Joachim H. R. , Rollenhagen Astrid 
Published: December 2019

Abstract
Synapses are key elements in the communication between neurons in any given network of the normal adult, developmental and pathologically altered brain. Synapses are composed of nearly the same structural subelements: a presynaptic terminal containing mitochondria with an ultrastructurally visible density at the pre- and postsynaptic apposition zone. The presynaptic density is composed of a cocktail of various synaptic proteins involved in the binding, priming and docking of synaptic vesicles inducing synaptic transmission. Individual presynaptic terminals (synaptic boutons) contain a couple of hundred up to thousands of synaptic vesicles. The pre- and postsynaptic densities are separated by a synaptic cleft. The postsynaptic density, also containing various synaptic proteins and more importantly various neurotransmitter receptors and their subunits specifically composed and arranged at individual synaptic complexes, reside at the target structures of the presynaptic boutons that could be somata, dendrites, spines or initial segments of axons.
Beside the importance of the network in which synapses are integrated, their individual structural composition critically determines the dynamic properties within a given connection or the computations of the entire network, in particular, the number, size and shape of the active zone, the structural equivalent to a functional neurotransmitter release site, together with the size and organization of the three functionally defined pools of synaptic vesicles, namely the readily releasable, the recycling and the resting pool, are important structural subelements governing the ‘behavior’ of synaptic complexes within a given network such as the cortical column.
In the late last century, neuroscientists started to generate quantitative 3D-models of synaptic boutons and their target structures that is one possible way to correlate structure with function, thus allowing reliable predictions about their function. The re-introduction of electron microscopy (EM) as an important tool achieved by modern high-end, high-resolution transmission-EM, focused ion beam scanning-EM, CRYO-EM and EM-tomography have enormously improved our knowledge about the synaptic organization of the brain not only in various animal species, but also allowed new insights in the ‘microcosms’ of the human brain in health and disease.
Stereocomplex electrospun fibers from high molecular weight of poly(L-lactic acid) and poly(D-lactic acid)
Authors: Maleki Homa , Barani Hossein 
Published: December 2019

Abstract
The stereocomplex formation is a promising method to improve the properties of poly(lactide) (PLA)-based products due to the strong interaction of the side-by-side arrangement of the molecular chains. Recently, electrospinning method has been applied to prepare PLA stereocomplex, which is more convenient. The objective of the current study is to make stereocomplexed PLA nanofibers using electrospinning method and compare their properties and structures with pure poly(l-lactide) (PLLA) fibers. The stereocomplexed fibers were electrospun from a blend solution of high molecular weight PLLA and poly(d-lactide) (1:1 ratio). The morphology of the obtained electrospun fibers was examined by scanning electron microscopy (SEM) and atomic force microscopy (AFM). Differential scanning calorimetry was applied to study their thermal properties and crystallinity. Fourier transform infrared spectroscopy (FTIR) test was conducted on the samples to characterize their chemical properties. The SEM and AFM images indicated that smooth uniform fibers with a cylindrical structure were produced. Besides, the FTIR results and thermal properties confirmed that only stereocomplex crystallites formed in the resulting fibers via the electrospinning method.
On the minimum reactant concentration required to prepare Au/M core-shell nanoparticles by the one-pot microemulsion route
Authors: Tojo C. , Buceta D. , López-Quintela M. A. 
Published: December 2019

AbstractThe minimum reactant concentration required to synthesize Au/M (M = Ag, Pt, Pd, Ru …) core-shell nanoparticles by the one-pot microemulsion route was calculated by a simulation model under different synthesis conditions. This minimum concentration was proved to depend on the reduction potential of the slower metal M and on the rigidity of the surfactant film composing the microemulsion. Model results were tested by comparing with Au/M nanoparticles taken from literature. In all cases, experimental data obey model predictions. From this agreement, one can conclude that the smaller the standard potential of the slower reduction metal, the lower the minimum concentration needed to obtain core-shell nanoparticles. In addition, the higher the surfactant flexibility, the higher the minimum concentration to synthesize metal segregated nanoparticles. Model prediction allows to quantify which is the best value of concentration to prepare different pairs of core-shell Au/M nanoparticles in terms of nature of M metal in the couple and microemulsion composition. This outlook may become an advanced tool for fine-tuning Au/M nanostructures.Graphical Abstract:
Synthesis and characterization of graphene quantum dots
Authors: Kundu Sumana , Pillai Vijayamohanan K. 
Published: December 2019

AbstractConventional inorganic semiconductor quantum dots (QDs) have numerous applications ranging from energy harvesting to optoelectronic and bio-sensing devices primarily due to their unique size and shape tunable band-gap and also surface functionalization capability and consequently, have received significant interest in the last few decades. However, the high market cost of these QDs, on the order of thousands of USD/g and toxicity limit their practical utility in many industrial applications. In this context, graphene quantum dot (GQD), a nanocarbon material and a new entrant in the quantum-confined semiconductors could be a promising alternative to the conventional toxic QDs due to its potential tunability in optical and electronic properties and film processing capability for realizing many of the applications. Variation in optical as well as electronic properties as a function of size, shape, doping and functionalization would be discussed with relevant theoretical backgrounds along with available experimental results and limitations. The review deals with various methods available so far towards the synthesis of GQDs along with special emphasis on characterization techniques starting from spectroscopic, optical and microscopic techniques along with their the working principles, and advantages and limitations. Finally, we will comment on the environmental impact and toxicity limitations of these GQDs and their hybrid nanomaterials to facilitate their future prospects.Graphical Abstract:Structure of doped, functionalized and hybrid GQDs
Us Presidents’ Political Discourse Analysis: George W. Bush and Barack Obama. A Pragmatics Approach
Authors: Tarish Abbas Hussein 
Published: December 2019

Abstract
An examination of the political discourse of presidents establishes an understanding of the factors that influence word choice and communication. Most notably, the context provided by presidents in their political discourse conveys the meaning intended by the speeches, which then influences the way the public reacts to what they have to say. Through knowledge of these factors, linguists can develop a more comprehensive understanding of the relationship between language and the perceptions of American presidents by both Americans and non-Americans. The purpose of this paper is to examine the political discourse of two American presidents – George W. Bush and Barack Obama – in order to identify the overall message intended by their speeches and the factors that influence their discourse.
Structural diversity in Cd(NCS)2-3-cyanopyridine coordination compounds: synthesis, crystal structures and thermal properties
Authors: Jochim Aleksej , Jess Inke , Näther Christian 
Published: December 2019

Abstract
Five new compounds with the compositions [Cd(NCS)2(3-cyanopyridine)2]
n
· 3-cyanopyridine (1), [Cd(NCS)2(3-cyanopyridine)2]
n
· 1/3 3-cyanopyridine (2), [Cd(NCS)2(3-cyanopyridine)2]
n
(3), {[Cd(NCS)2]2(3-cyanopyridine)3}
n
(4), and {[Cd(NCS)2]3(3-cyanopyridine)4}
n
(5) have been obtained by the reaction of Cd(NCS)2 with 3-cyanopyridine in different solvents. While large amounts of compounds 1–4 could be prepared as powders, only a few single crystals of 5 were accidently obtained. Thermoanalytical investigations have shown that 4 could also be obtained by annealing of 1 or 2 and that under slightly different conditions 5 could be obtained as part of a mixture with 4. The crystal structures of all compounds can be divided in two sets of compounds. Compounds 1, 2 and 3 consist of chains in which the Cd cations show three different coordination environments and in which the coligands are only terminally bonded. In the structures of 4 and 5 similar chains are observed, which are connected into layers via some of the 3-cyanopyridine coligands.
Pancreatic alpha-cell mass across adult human lifespan
Authors: Moin Abu Saleh Md , Cory Megan , Gurlo Tatyana , Saisho Yoshifumi , Rizza Robert A , Butler Peter C , Butler Alexandra E 
Published: December 2019

Aim
To establish pancreatic alpha-cell mass in lean, non-diabetic humans over the adult lifespan, performed as a follow-up study to beta-cell mass across the adult human lifespan.

Methods
We examined human pancreatic autopsy tissue from 66 lean, non-diabetic individuals aged from 30 to 102 years, grouped into deciles: 3rd (30–39 years), 4th (40–49 years), 5th (50–59 years), 6th (60–69 years), 7th (70–79 years), 8th (80–89 years) and 9th deciles (90+ years). Sections of pancreas were immunostained for glucagon and analyzed for fractional alpha-cell area. Population-based pancreatic volume data were used to calculate alpha-cell mass.

Results
With advanced age, the exocrine pancreas undergoes atrophy demonstrated by increased fat area (as % exocrine area) (0.05 ± 0.01 vs 1.6 ± 0.7% fat area of total exocrine pancreas, 3rd vs 9th decile, P < 0.05). Consequently, islet density increases with age (2.7 ± 0.4 vs 10.5 ± 3.3 islets/mm2, 3rd vs 9th decile, P < 0.05). Alpha-cell fractional area increases with advanced age (0.34 ± 0.05% vs 0.73 ± 0.26%, 3rd vs 9th decile, P < 0.05). However, alpha-cell mass remains constant at ~190 mg throughout the adult lifespan in lean, non-diabetic humans. Within islets, alpha-cell distribution between mantle and core is unchanged across deciles (1862 ± 220 vs 1945 ± 200 vs 1948 ± 139 alpha cells in islet mantle/mm2, 3rd vs 6th vs 9th decile, P = 0.93 and 1912 ± 442 vs 1449 ± 123 vs 1514 ± 168 alpha cells in islet core/mm2, 3rd vs 6th vs 9th decile, P = 0.47), suggesting that human islets retain their structural organization in the setting of age-related exocrine atrophy.

Conclusions
Consistent with our previous findings for beta-cell mass, alpha-cell mass remains constant in humans, even with advanced age. Pancreatic endocrine cells are much more robustly preserved than exocrine cells in aged humans, and islets maintain their structural integrity throughout life.
Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages
Authors: Janssen William J , Danhorn Thomas , Harris Chelsea , Mould Kara J , Lee Frank Fang-Yao , Hedin Brenna R , D’Alessandro Angelo , Leach Sonia M , Alper Scott 
Published: December 2019

AbstractAlveolar macrophages serve as central orchestrators of inflammatory responses in the lungs, both initiating their onset and promoting their resolution. However, the mechanisms that program macrophages for these dynamic responses are not fully understood. Over 95% of all mammalian genes undergo alternative pre-mRNA splicing. While alternative splicing has been shown to regulate inflammatory responses in macrophages in vitro, it has not been investigated on a genome-wide scale in vivo. Here we used RNAseq to investigate alternative pre-mRNA splicing in alveolar macrophages isolated from lipopolysaccharide (LPS)-treated mice during the peak of inflammation and during its resolution. We found that lung inflammation induced substantial alternative pre-mRNA splicing in alveolar macrophages. The number of changes in isoform usage was greatest at the peak of inflammation and involved multiple classes of alternative pre-mRNA splicing events. Comparative pathway analysis of inflammation-induced changes in alternative pre-mRNA splicing and differential gene expression revealed overlap of pathways enriched for immune responses such as chemokine signaling and cellular metabolism. Moreover, alternative pre-mRNA splicing of genes in metabolic pathways differed in tissue resident vs. recruited (blood monocyte-derived) alveolar macrophages and corresponded to changes in core metabolism, including a switch to Warburg-like metabolism in recruited macrophages with increased glycolysis and decreased flux through the tricarboxylic acid cycle.