bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low Interleukin-22 Binding Protein Is Associated With High Mortality in Alcoholic Hepatitis and Modulates Interleukin-22 Receptor Expression
Authors: Støy Sidsel , Laursen Tea Lund , Glavind Emilie , Eriksen Peter Lykke , Terczynska-Dyla Ewa , Magnusson Nils Erik , Hamilton-Dutoit Stephen , Mortensen Frank Viborg , Veidal Sanne Skovgård , Rigbolt Kristoffer , Riggio Oliviero , Deleuran Bent , Vilstrup Hendrik , Sandahl Thomas Damgaard. 
Published: August 2020

INTRODUCTION:
In alcoholic hepatitis (AH), high interleukin (IL)-22 production is associated with disease improvement, purportedly through enhanced infection resistance and liver regeneration. IL-22 binding protein (BP) binds and antagonizes IL-22 bioactivity, but data on IL-22BP in liver disease suggest a complex interplay. Despite the scarcity of human data, IL-22 is in clinical trial as treatment of AH. We, therefore, in patients with AH, described the IL-22 system focusing on IL-22BP and associations with disease course, and mechanistically pursued the human associations in vitro.

METHODS:
We prospectively studied 41 consecutive patients with AH at diagnosis, days 7 and 90, and followed them for up to 1 year. We measured IL-22 pathway proteins in liver biopsies and blood and investigated IL-22BP effects on IL-22 in hepatocyte cultures.

RESULTS:
IL-22BP was produced in the gut and was identifiable in the patients with AH' livers. Plasma IL-22BP was only 50% of controls and the IL-22/IL-22BP ratio thus elevated. Consistently, IL-22-inducible genes were upregulated in AH livers at diagnosis. Low plasma IL-22BP was closely associated with high 1-year mortality. In vitro, IL-22 stimulation reduced IL-22 receptor (R) expression, but coincubation with IL-22BP sustained IL-22R expression. In the AH livers, IL-22R mRNA expression was similar to healthy livers, although IL-22R liver protein was higher at diagnosis.

DISCUSSION:
Plasma IL-22BP was associated with an adverse disease course, possibly because its low level reduces IL-22R expression so that IL-22 bioactivity was reduced. This suggests the IL-BP interplay to be central in AH pathogenesis, and in future treatment trials (see Visual abstract, Supplementary Digital Content 5, http://links.lww.com/CTG/A338).
Auswirkungen von Produktivitätsmanagement und Digitalisierung auf die Work-Life-Balance
Authors: Weber Marc-André , Koczy Amelia , Stahn Catharina , Jeske Tim 
Published: August 2020

Die Digitalisierung bietet Möglichkeiten zur besseren Gestaltung von Arbeit und ihren Bedingungen, wodurch sowohl Beschäftigte als auch Unternehmen (z. B. im Sinne einer Optimierung der Produktivität) profitieren kön­nen. Durch Änderungen der Arbeitsorganisation und -gestaltung ergeben sich Auswirkungen für die Beschäftigten, insbesondere wenn durch die Digitalisierung Möglichkeiten zur Erweiterung der zeitlichen Arbeitsflexibilität entstehen und Grenzen zwischen Privat- und Arbeitsleben verschwimmen. Alle diese Aspekte können sich auf physische und psychische Belastungen auswirken. Des­halb stellt sich die Frage, wie die digitale Transformation von Unternehmen umgesetzt werden sollte, um die zunehmende Integration von Privat- und Arbeitsleben so zu gestalten, dass sowohl die Beschäftigten als auch die Betriebe profitieren und negative Auswirkungen ver­mieden werden. Hierfür stellen die Autoren ausgewählte Studienergebnisse zur Nutzung der Digitalisierung für das betriebliche Produktivitäts­management in der deutschen Metall- und Elek­tro­industrie vor. Der Schwerpunkt liegt auf den Wechselwirkungen zwischen Digita­li­sie­rung und Produktivitätsmanagement und deren Auswirkungen auf die Beschäftigten. Ab­schlie­ßend nennen die Autoren Handlungs­empfehlungen für die Gestaltung der Digitalisierung.
eStandards – Enabler der digitalen Transformation von Geschäftsmodellen
Authors: Abdelkafi Nizar , Radic Marija 
Published: August 2020

Der vorliegende Beitrag befasst sich mit der Relevanz von eStandards für die digitale Transformation von Geschäftsmodellen. eStandards sind elektronische Standards zur Vereinheitlichung von Datenaustauschformaten, die Medienbrüche? innerhalb der Wertschöpfungskette verringern. Beispiele für eStandards sind Standards wie eCl@ss, der Produkte und Dienstleistungen branchenübergreifend eindeutig beschreibt und klassifiziert oder ZUGFeRD, ein übergreifendes Format für elektronische Rechnungen, das für den Rechnungsaustausch zwischen Unternehmen, Behörden und Verbrauchern genutzt werden kann und den Austausch strukturierter Daten zwischen Rechnungssteller und Rechnungsempfänger ermöglicht (eCl@ss, 2018, FeRD, 2018). Zu den eStandards gehören auch solche Standards, welche die Kommunikation zwischen Maschinen im Rahmen von Industrie 4.0 ermöglichen.
Für diesen Beitrag haben wir 20 eStandards-Projekte analysiert, die im Rahmen des Förderschwerpunkts „Mittelstand-Digital“ durch das Bundesministerium für Wirtschaft und Energie (BMWi) gefördert wurden. Insbesondere gehen wir auf die Chancen und Hemmnisse bei der Implementierung von eStandards ein. Unsere Analyse verdeutlicht, dass eStandards primär operative Geschäftsprozesse unterstützen. Sie tragen eher dazu bei, Geschäftsmodelle inkrementell zu verändern. Die Verknüpfung von eStandards mit dem digitalen Reifegrad, d.h. mit dem Fortschritt der digitalen Transformation eines Unternehmens und somit dem digitalen Wettbewerbsvorteil (Gassman und Sutter, 2016), zeigt, dass bestimmte eStandards nur bei niedrigen digitalen Reifegraden geeignet sind, um die ersten Schritte in Richtung Digitalisierung zu ermöglichen, während andere eStandards in fortschrittlichen Stadien der Digitalisierung Anwendung finden.
Somit unterstützen eStandards die Digitalisierung von bestehenden Geschäftsmodellen, aber sie führen nicht zwangsläufig zu komplett digitalen Geschäftsmodellen. Unternehmen mit hohen Reifegraden sind allerdings diejenigen, die eher in der Lage sind neue digitale Geschäftsmodelle und Dienstleistungen zu entwickeln und zu implementieren.
LEGO® Serious Play® neu gedacht – die Arbeitswelt von 2038
Authors: Zeiner-Fink Susann , Feldhoff Annika 
Published: August 2020

Im Rahmen der Erkenntnisgewinnung über reflexive partizipative Prozesse und deren Umsetzung im organisationalen Kontext finden sich nur wenige Methoden, die den Erfahrungshintergrund aller Beteiligten berücksichtigen und so ein gemeinsam geteiltes Verständnis erzeugen.
Als Strategieentwicklungsmethode von Kjeld Kirk Kristiansen 1996 entwickelt, hat sich LEGO® Serious Play® im Laufe der Zeit als Workshop-Format für Unternehmen etabliert. Mit Hilfe von LEGO®-Steinen sollen dabei unbewusste Erfahrungs- und Wissenspotentiale aufgedeckt werden. Ziel ist es, die Vorteile des Spielens und Modellierens mit realen Problemstellungen zu verknüpfen. Hierdurch kann ein Beitrag zum Lernen und Verstehen geleistet und gewohnte Muster durchbrochen werden.
Der vorliegende Beitrag stellt die Methode LEGO® Serious Play® in ihren Grundzügen vor, zeigt einen möglichen Umsetzungsprozess auf und beleuchtet, wie der Ansatz bereits in der Unternehmenspraxis und Forschung eingesetzt wurde. Darüber hinaus wird das an das LEGO® Serious Play® angelehnte Konzept der Themeninsel „Arbeitswelt 2038“ im Rahmen der innteract Konferenz 2018 erläutert und mit Bezug auf sein Potential hinsichtlich einer Weiterentwicklung der klassischen LEGO® Serious Play®-Workshop-Methodik erörtert.
CheckAge - Screening-Verfahren für die Bewertung alter(n)sgerechter Arbeitsplätze
Authors: Börner Kerstin , Löffler Thomas , Bullinger-Hoffmann Angelika C. 
Published: August 2020

Der CheckAge „Alter(n)sgerechte Arbeitsplätze“ ist ein Screening-Verfahren, das es ermöglicht, altersSPEZIFISCHE Potentiale und Handlungsbedarf zur alter(n)s-gerechten Arbeitsgestaltung im Unternehmen aufzudecken. Er dient als Orientierungshilfe und kann von Personen mit ergonomischen Grundkenntnissen durchgeführt werden. CheckAge eignet sich für Arbeitsplätze, vorwiegend im produktionsnahen Bereich, bei denen Belastungen durch Körperhaltung, Aktionskräfte, Lastenhandhabung und repetitive Tätigkeiten auftreten. Der Mehrwert des CheckAge „Alter(n)sgerechte Arbeitsplätze“ besteht in der Möglichkeit, neben einer altersNEUTRALEN Bewertung auch altersSPEZIFISCHE Faktoren zu berücksichtigen. Der CheckAge besteht aus dem Bewertungsbogen (zwei A4 Seiten) und dem Maßnahmenblatt zum Maßnahmencontrolling. Vorliegender aw&I Report unterstützt die Anwendung mit Erläuterungen zu altersbedingten Fähigkeitsänderungen, Bewertungshilfen und Vorschlägen für Verbesserungsmaßnahmen.
An Overview of Massive Open Online Courses with Topics of Robotics
Authors: Ganbat Danaa , Tudevdagva Uranchimeg 
Published: August 2020

This article reports short overview of massive open online courses for “robotic” topic. Extensive use of mobile devices opens up various opportunities for educational institutions to transfer contents to learners. Modern learners prefer to manage their learning by personal way. Many online courses are confirming this fact. Nowadays we can find unlimited number of contents on the internet. Almost all universities offer own online courses with various topics. In the last decade massive open online course (MOOC) became one of the opportunities to keep educated.
The robotics is main focus of this issue, therefore we are trying to conduct small study on online educational contents with this topic. We selected five MOOCs in our study. Main criteria of selection were personal experience of author with these MOOCs. An evaluation of MOOCs is not an aim of the article. Through this article we tried to make visible opportunities to get education on robotics free by online with your personal learning management time.
Osmotic Oedometer Using Sodium Chloride Solution and Reverse Osmosis Membrane
Authors: Bulolo Sam , Leong Eng-Choon 
Published: August 2020

Abstract
There are two suction application techniques in laboratory testing of unsaturated soils: (1) the axis-translation technique in which pore-air pressure is elevated above atmospheric pressure and pore-water pressure is at an atmospheric or a small positive value to give a matric suction and (2) using salt solutions. Salt solutions can be used to control the relative humidity of the air surrounding the soil specimen in the vapor equilibrium technique or as an osmotic suction applied through a semipermeable membrane in the osmotic technique. The salt solution in the vapor equilibrium technique applies a total suction, whereas the salt solution in the osmotic technique induces a matric suction on the soil specimen. Unlike the axis-translation technique and vapor equilibrium technique, the osmotic technique does not require a sealed chamber, but it is not as popular as the axis-translation technique and vapor equilibrium technique because the commonly used poly(ethylene glycol) solution and cellulosic membrane are susceptible to degradation during long-duration tests. This paper investigates the osmotic technique using sodium chloride solutions and a reverse osmosis membrane in a conventional oedometer. The performance of the updated osmotic oedometer was evaluated using kaolin–bentonite specimens. A kaolin–bentonite specimen was first mechanically consolidated, and thereafter the water within the base of the oedometer was replaced with sodium chloride solution. The results show that osmotic technique causes the soil specimen to be compressed further. However, the measured matric suction of the soil specimen at equilibrium is less than the applied suction. The difference is attributed to the membrane resistance effect. The updated osmotic oedometer is attractive, as it eliminates the drawbacks of the previous osmotic oedometer, and it can theoretically apply matric suction as high as 5,000 kPa.
Developing the Workforce for Next-Generation Smart Manufacturing Systems: A Multidisciplinary Research Team Approach
Authors: Kovalenko Ilya , Balta Efe C. , Qamsane Yassine , Koman Patricia D. , Zhu Xiao , Lin Yikai , Tilbury Dawn M. , Morley Mao Z. , Barton Kira 
Published: August 2020

Abstract
As real-world systems become more complex and connected, the industrial sector requires engineers who can solve problems across multiple disciplines and work with people across various educational backgrounds. This is particularly apparent in the manufacturing industry, as the integration of new manufacturing system technology requires knowledge in a diverse set of fields, such as physics, computer science, and engineering, to name a few. To properly educate the next workforce in manufacturing, engineering education needs to incorporate cross-disciplinary, project-driven learning that provides students with ample opportunities to work with cutting-edge manufacturing technology. At the University of Michigan, the Secure Cloud Manufacturing Multidisciplinary Design Program team focuses on developing the next generation of manufacturing engineers through research-driven multidisciplinary projects. A group of 7–22 students work on several multisemester-long projects that focus on providing hands-on, student-driven learning. Each semester, these students work closely with several faculty members, research scientists, postdocs, and graduate students to propose, develop, and conduct industry-relevant research projects on multiple manufacturing testbeds. Example projects have included the implementation of a smart quality-control camera, the development of digital twins for manufacturing processes, and the integration of secure cloud-based infrastructures for industrial controllers. In these highly collaborative and multidisciplinary project groups, students learn from each other, take on leadership roles, and disseminate their work through technical reports and presentations to academic and industry experts. Students leave the group with an understanding of the capabilities and needs of future manufacturing systems, ready to become, and lead, the next set of manufacturing engineers.
La necesidad de la aplicación del principio de transparencia en la puesta en práctica del acuerdo Unión Europea-MERCOSUR
Authors: Molina del Pozo Carlos Francisco 
Published: August 2020

Tras más de 20 años de reuniones y deliberaciones, el 28 de junio de 2019, la UE y el MERCOSUR concluyeron las negociaciones del Acuerdo de Asociación, el cual presenta como beneficios generales los siguientes: primero, el fortalecimiento de vínculos políticos, culturales y económicos; segundo, la creación de un entorno económico, normativo e institucional de acuerdo con la realidad actual y que transmita confianza, dándose oportunidades de inversión; tercero, la promoción de la integración entre las regiones y el desarrollo de las economías; cuarto, la previsión de adaptación de determinados plazos para las empresas, comprometiéndose la UE a eliminar sus aranceles con carácter previo.
21 OVARIOTOMY
Authors: Krassovsky A. Ya. 
Published: August 2020

№ 152. Colloid unilocular cyst of the right ovary without adhesions. Recovery.
A.N. Shch., A peasant woman in the Yaroslavl province, was admitted to the Maryinsky Gynecological Department on March 17, 1888 with a complaint of heaviness in the abdomen and pain in the lower back.
gCAPjoint, A Software Package for Full Moment Tensor Inversion of Moderately Strong Earthquakes with Local and Teleseismic Waveforms
Authors: Bai Qipeng , Ni Sidao , Chu Risheng , Jia Zhe 
Published: August 2020

AbstractEarthquake moment tensors and focal depths are crucial to assessing seismic hazards and studying active tectonic and volcanic processes. Although less powerful than strong earthquakes (M 7+), moderately strong earthquakes (M 5–6.5) occur more frequently and extensively, which can cause severe damages in populated areas. The inversion of moment tensors is usually affected by insufficient local waveform data (epicentral distance &lt;5°) in sparse seismic networks. It would be necessary to combine local and teleseismic data (epicentral distance 30°–90°) for a joint inversion. In this study, we present the generalized cut-and-paste joint (gCAPjoint) algorithm to jointly invert full moment tensor and centroid depth with local and teleseismic broadband waveforms. To demonstrate the effectiveness and explore the limitations of this algorithm, we perform case studies on three earthquakes with different tectonic settings and source properties. Comparison of our results with global centroid moment tensor and other catalog solutions illustrates that both non-double-couple compositions of the focal mechanisms and centroid depths can be reliably recovered for very shallow (&lt;10  km) earthquakes and intermediate-depth events with this software package.
Validity of Resolving the 785 km Discontinuity in the Lower Mantle with P′P′ Precursors?
Authors: Zhang Baolong , Zeng Xiangfang , Xie Jun , Cormier Vernon F. 
Published: August 2020

AbstractP ′ P ′ precursors have been used to detect discontinuities in the lower mantle of the Earth, but some seismic phases propagating along asymmetric ray paths or scattered waves could be misinterpreted as reflections from mantle discontinuities. By forward modeling in standard 1D Earth models, we demonstrate that the frequency content, slowness, and decay with distance of precursors about 180 s before P′P′ arrival are consistent with those of the PKPPdiff phase (or PdiffPKP) at epicentral distances around 78° rather than a reflection from a lower mantle interface. Furthermore, a beamforming technique applied to waveform data recorded at the USArray demonstrates that PKPPdiff can be commonly observed from numerous earthquakes. Hence, a reference 1D Earth model without lower mantle discontinuities can explain many of the observed P′P′ precursors signals if they are interpreted as PKPPdiff, instead of P′785P′. However, this study does not exclude the possibility of 785 km interface beneath the Africa. If this interface indeed exists, P′P′ precursors at distances around 78° would better not be used for its detection to avoid interference from PKPPdiff. Indeed, it could be detected with P′P′ precursors at epicentral distances less than 76° or with other seismic phases such as backscattered PKP·PKP waves.
Low neutrophil-to-lmphocyte ratio decreases risk of coronavirus disease in pregnant women
Authors: Anggraini Nutria Widya Purna , Sulistyowati Sri 
Published: August 2020

BACKGROUNDCoronavirus Infection 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an emergency condition for global public health. Early detection of COVID-19 in pregnant women is needed. The neutrophil-to-lymphocyte ratio (NLR), as a marker of viral inflammatory response, is used to determine the presence of a viral or bacterial infection, both acute and chronic. The objective of this study was to determine the relationship between NLR and the polymerase chain reaction (PCR) swab test results in pregnant women with suspected coronavirus disease 2019.METHODSA cross-sectional study was conducted on 9 pregnant women with suspected COVID-19. The subjects were inpatients at Moewardi Hospital Surakarta from 19 April-19 May 2020, who had rapid tests, complete blood examinations, and PCR swab tests. The NLR was categorized based on early warning scores according to research developed at Zhejiang University, with cut-off point 5.8. Diagnosis of COVID-19 was confirmed by PCR swab tests. Relation between NLR and PCR swab results was analyzed by the prevalence ratio.RESULTSTwo patients (22.2%) had NLR >5.8, with positive swab results in both (100%). Seven patients with NLR <5.8 had positive swabs in only one (33.3%). The relationship between NLR and PCR swab test results showed a prevalence ratio of 0.143 (95% CI 0.023-0.877).CONCLUSIONPregnant women with NLR < 5.8 had a decreased risk of COVID-19. Routine blood examination is more suitable for finding pregnant women with suspected COVID-19.
Immunopathological study of crescentic glomerulonephritis with special reference to antineutrophilic cytoplasmic antibodies
Authors: Sharma Priyankar , Gahoi Khushboo , Usha  , Nongphud Mary June , Mishra J K 
Published: August 2020

Crescentic Glomerulonephritis (CGN) is produced by many factors like Antineutrophilic Cytoplasmic Antibody (ANCA), Anti Glomerular Basement Membrane Antibodies (Anti GBM Ab) or immune complexes (IC). Aim of the study was to see prevalence of ANCA in CGN and subtypes of CGN.Total 50 cases of CGN were studied from February 2016 to July 2017. All auto antibodies (ANCA, ANA, DNA) were performed by ELISA method. Formalin fixed, paraffin embedded tissue was used for histopathology.In 50 cases of CGN (26 males, 24 females) age range was 13 – 86 years. ANCA was positive in 72%. About 60% cases were of Type III (Pauci-immune) followed by Type IV (combined type 1 and type 3), Type V (ANCA, immune-complex and anti GBM negative) (12% each), Type I (Anti GBM Ab mediated) and Type II (immune complex mediated) (8% each).About 14% patients were below 14 years of age, 52% were between 21 to 40 years, 24% were between 41 to 60 years and 10% were above 61 years of age.In Type III CGN, 53.33% were MPO positive, 40% were PR3 positive and 6.7% were both MPO and PR3 positive, while in Type IV CGN, 83.33% were MPO positive and 16.66% were PR3 positive. Small vessel vasculitis was found in 83.3% of the patients of Type V, 69.9% patients of Type III and 50% of patients of Type I and Type IV and 25% of patients of Type II CGN. Vasculitis of medium sized blood vessels was seen in 50% of Type IV, 20% of Type III CGN, 25% of Type I and 16.7% of Type V CGN.About 41 cases of CGN, suspected highly for small vessel vasculitis, were subjected for CD34 staining. In H&E stain, only 58% of the cases showed vasculitis and peritubular capillaritis; but after CD 34 staining, all cases showed arteriolitis and peritubular capillaritis. About 33.33% of Type IV and 26.6% of Type III had granulomas in glomeruli; while 26.6% of Type III, 25% of Type I and IV each, 16% of Type IV and V each had granulomas in interstitium. Two cases (66.6%) of Type III had granulomas in blood vessels. Out of 50 cases of CGN, 14 cases (28%) after investigations turned out to be cases of Lupus nephritis with ANCA positivity in 85.5% of the cases. MPO ANCA was positive in 50%, PR3 ANCA in 28.57% and in one case both ANCA and anti GBM Ab were positive. Granulomatous Polyangitis (GPA) was seen in 8 cases while Eosinophilic Granulomatous Polyangitis (EGPA) was found in one case and rest of the cases were of microscopic polyangiitis (MPA). PR3 ANCA was positive in 87.5% cases of GPA, whereas in EGPA, MPO ANCA was positive.SLE can also be associated with ANCA mediated CGN. ANCA produces small vessel vasculitis which can be better visualised after CD34 staining. Detection of ANCA will help the clinicians for planning aggressive immunosuppressive therapy.