bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geology, Mineralogy, Geochemistry, and Genesis of Bentonite Deposits in Miocene Volcano–Sedimentary Units of the Balikesir Region, Western Anatolia, Turkey
Authors: Kadİr Selahattİn , Külah Tacİt , Erkoyun Hülya , Christidis George E. , Arslanyan Raffİ 
Published: December 2019

AbstractThe widespread Balıkesir bentonite deposits within the Miocene volcano-sedimentary units in western Anatolia have economic potential; they are important raw materials for the paper and bleaching industries in Turkey. No detailed geological, mineralogical, geochemical, or genesis characterizations of these bentonite deposits have been carried out to date. The present study was undertaken to close this gap. The mineralogical characteristics of the bentonites and their parent rocks were examined using polarized-light microscopy, X-ray powder diffractometry (XRD), scanning- and transmission-electron microscopies (SEM–EDX and TEM), and chemical (ICP–AES and –MS) methods. In the bentonite deposits, smectite is associated with smaller amounts of illite, chlorite, quartz, feldspar, dolomite, calcite, opal-CT, and amphibole. The smectite was identified by sharp basal reflections at 14.42–14.93 Å. Plagioclase and sanidine crystals in volcanic units are altered and sericitized. Biotite and hornblende are partly to completely Fe-(oxyhydr)oxidized and chloritized. Smectite flakes occur on altered feldspar and mica grains and devitrified volcanic glass fragments in association with or without calcite ± dolomite crystals. Increasing Al+Fe+Mg/Si ratios with increasing degree of alteration reveal that hydration of volcanogenic grains (feldspar, mica, hornblende, glass shard) favored precipitation of smectite with montmorillonite composition, with an average structural formula: (Ca0.31Na0.05K0.08)(Al2.72Fe0.17Mg1.27Ti0.011Mn0.01)(Si7.94Al0.06)O20(OH)4. The concentration of Al2O3 and MgO and increase of LREE/HREE ratio, and a distinct, negative Eu anomaly show that smectite was probably formed as a result of the decomposition of volcanic feldspar, mica, amphibole, and volcanic glass. Association of carbonate rocks within the smectite-rich material and the absence of chlorite and detrital materials such as rock fragments in the bentonites suggest that the bentonite deposits formed authigenetically as ‘primary bentonites’ from volcanoclastic materials deposited in a calm lacustrine–palustrine environment during an early diagenetic process.
Correlation Between Salivary, Platelet and Central Serotonin Levels in Children
Authors: Egri Csilla , Dunbar Mary , Horvath Gabriella Ana 
Published: December 2019

ABSTRACT:Background:Serotonin (5-HT) is a neurotransmitter synthesized in both the central nervous system (CNS) and in enterochromaffin cells of the gut. 5-HT biosynthesis is separate between the periphery and the CNS. Any observed correlations between centrally and peripherally measured 5-HT remain to be elucidated. Previous efforts have looked for a noninvasive marker of central serotonin, including serotonin in whole blood, plasma, platelets, saliva, and urine; however, results are conflicting.Aim:Finding a noninvasive marker for central serotonin turnover that can be used for diagnosis and therapeutic monitoring in patients with primary neurotransmitter deficiencies.Methods:Inclusion criterion was all children presenting with neurological symptoms whose clinical investigations included lumbar puncture (LP) for cerebrospinal fluid (CSF) collection and neurotransmitter metabolite analysis, were recruited. For central serotonin turnover, the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) was used. Bivariate correlation between the serotonin levels in CSF (5HIAA), platelets, and saliva was calculated.Results:Twenty-six patients (aged 6 months to 15 years) with various neurologic presentations had LP for CSF collection and neurotransmitter metabolite analysis as part of their clinical care. An additional salivary and blood sample was obtained at the same time. Eighteen patients had suitable samples for quantitative measure of serotonin. There was no correlation between platelet serotonin and CSF 5HIAA levels (Pearson’s coefficient of correlation – PCC: 0.010) or between salivary serotonin and CSF 5HIAA (PCC: 0.258). There was a strong negative correlation between salivary and platelet serotonin (PCC: −0.679).Conclusion:Our findings suggest that salivary serotonin measurement is not a suitable noninvasive marker for measuring central serotonin turnover.
Darwin’s bureaucrat
Authors: Smith Kevin B. , Renfro Jayme L. N. 
Published: December 2019

AbstractThe study of bureaucratic behavior—focusing on control, decision-making, and institutional arrangements—has historically leaned heavily on theories of rational choice and bounded rationality. Notably absent from this research, however, is attention to the growing literature on biological and especially evolutionary human behavior. This article addresses this gap by closely examining the extant economic and psychological frameworks—which we refer to as “Adam Smith’s bureaucrat” and “Herbert Simon’s bureaucrat”—for their shortcomings in terms of explanatory and predictive theory, and by positing a different framework, which we call “Charles Darwin’s bureaucrat.” This model incorporates new insights from an expanding multidisciplinary research framework and has the potential to address some of the long-noted weaknesses of classic theories of bureaucratic behavior.
Constructing the ‘automatic’ Greenwich time system: George Biddell Airy and the telegraphic distribution of time,c.1852–1880
Authors: ISHIBASHI YUTO 
Published: December 2019

AbstractIn the context of the telegraphic distribution of Greenwich time, while the early experiments, the roles of successive Astronomers Royal in its expansion, and its impacts on the standardization of time in Victorian Britain have all been evaluated, the attempts of George Biddell Airy and his collaborators in constructing the Royal Observatory's time signals as the authoritative source of standard time have been underexplored within the existing historical literature. This paper focuses on the wide-ranging activities of Airy, his assistant astronomers, telegraph engineers, clockmakers and others, which served to increase the reliability of the Royal Observatory's time service between the 1850s and 1870s. Airy and his collaborators aimed to mechanize and automate their telegraphic time distribution system in order to improve its accuracy and reliability. The accomplishment of such technological innovations was disseminated via public lectures, journal articles and correspondence with experts, secondary distributors of standard time and the general public. These communications were used to build public trust in the Greenwich time service. However, the unexplored archival material used in the present paper provides fresh insight into the unstable nature of the Greenwich time system, including its clear limits in terms of its scale of automation and degree of accuracy.
On Reciprocity, Revenge, and Replication: A Rejoinder to Walzer, McMahan, and Keohane
Authors: Sagan Scott D. , Valentino Benjamin A. 
Published: December 2019

AbstractIn their contributions to the symposium “Just War and Unjust Soldiers,” Michael Walzer, Jeff McMahan, and Robert O. Keohane add greatly to our understanding of how best to study and apply just war doctrine to real-world conflicts. We argue, however, that they underestimate both the degree to which the American public seeks revenge, rather than just reciprocity, and the extent of popular acceptance of violations of noncombatant immunity by soldiers perceived to be fighting for a just cause. We call on empirical political scientists, lawyers, psychologists, and historians to engage with moral philosophers and political theorists in debates about the influence of just war theory and the laws of armed conflict.
When Migration Policy Isn't about Migration: Considerations for Implementation of the Global Compact for Migration
Authors: Bloom Tendayi 
Published: December 2019

AbstractThe fluid use of the terminology associated with “migration governance” can obscure its intention and implications. Different meanings of core terminology risks allowing troubling policies that are not really about migration, understood widely as border crossing, or even more broadly as human movement, to be legitimized. UN-level coordination with regard to “migration governance” needs to be part of addressing this concern. For example, this article advocates explicitly engaging with this risk through the implementation of the Global Compact for Safe, Orderly and Regular Migration. It considers this issue from the perspectives of a handful of countries, each of which has its own complex relationship to the compact. It argues that in each of these apparently very different contexts, policies identified as being directed at “migration control” can be found to be directed not at controlling migration but at reconfiguring existing and stable state societies along ethnic, racial, linguistic, and other lines. The development of implementation plans for the Global Compact for Migration provides the opportunity to interrogate the purposes of “migration governance” and to find mechanisms to address its hidden uses.
Privacy, People, and Markets
Authors: Hull Gordon 
Published: December 2019

AbstractMost current work on privacy understands it according to an economic model: individuals trade personal information for access to desired services and websites. This sounds good in theory. In practice, it has meant that online access to almost anything requires handing over vast amounts of personal information to the service provider with little control over what happens to it next. The two books considered in this essay both work against that economic model. In Privacy as Trust, Ari Ezra Waldman argues for a new model of privacy that starts not with putatively autonomous individuals but with an awareness that managing information flows is part of how people create and navigate social boundaries with one another. Jennifer Rothman's Right of Publicity confronts the explosive growth of publicity rights—the rights of individuals to control and profit from commercial use of their name and public image—and, in so doing, she exposes the poverty of treating information disclosure merely as a matter of economic calculation. Both books emphasize practical and doctrinal solutions to the problems they identify. In this essay, I take a step back and draw out the extent to which they converge on a fundamentally important point: the blunt application of market logic with its tools of property and contracts fails to protect the interests that lead us to turn to privacy in the first place; the tendency to economize privacy is a significant part of why we inadequately protect it.
Association of urinary polycyclic aromatic hydrocarbons and obesity in children aged 3–18: Canadian Health Measures Survey 2009–2015
Authors: Bushnik Tracey , Wong Suzy L. , Holloway Alison C. , Thomson Errol M. 
Published: December 2019

AbstractPolycyclic aromatic hydrocarbons (PAHs) may contribute to obesity. Childhood obesity is a strong predictor of adult obesity and morbidity; however, the relationship between PAHs and obesity in young children (e.g., aged 3–5) has not been studied. We examined the association between urinary PAH metabolites and measures of obesity in children. We analyzed data from 3667 children aged 3–18 years who participated in the Canadian Health Measures Survey (CHMS, 2009–2015). We ran separate multivariable linear models to estimate the association between quartiles of PAH metabolites and each of body mass index (BMI) percentile, waist circumference (WC), and waist-to-height ratio (WHtR) in the total population, as well as in the age subgroups 3–5, 6–11, and 12–18, adjusting for age, sex, ethnicity, education, income quintile, diet, creatinine, and exposure to environmental tobacco smoke. A multinomial logistic regression model estimated adjusted odds ratios for risk of central obesity. BMI, WC, and WHtR were positively associated with total PAH and naphthalene metabolites in the total population aged 3–18 and in age groups 6–11 and 12–18. In 3–5 year olds, WHtR, but not BMI, was significantly associated with total PAH, naphthalene, and phenanthrene metabolites. Overall, those in the highest quartile for naphthalene or total PAH metabolites had three times greater odds of having central obesity compared with those in the lowest quartile. Urinary PAH metabolites are associated with WHtR, an indicator of central obesity and predictor of health risks associated with obesity, in children as young as 3–5.
The Assessment and Comparison of TMPA and IMERG Products Over the Major Basins of Mainland China
Authors: Su Jianbin , Lü Haishen , Ryu Dongryeol , Zhu Yonghua 
Published: December 2019

AbstractThe Integrated Multi‐satellitE Retrievals for Global Precipitation Measurement mission (IMERG) aims to deliver the “best” precipitation estimation from space and has attracted much attention. The Version 05 of IMERG products including the near‐real‐time “Early” and “Late” run products (IMERG‐E and IMERG‐L, respectively), and the post‐real‐time “Final” run IMERG product (IMERG‐F) are assessed at both national and basin scales against gauge observations over Mainland China for a 4‐year period (from April 2014 to March 2018). As control products for comparison, their predecessor Tropical Rainfall Measurement Mission (TRMM) Multi‐satellite Precipitation Analysis (TMPA) products (i.e., TMPA‐RT and TMPA‐V7) are also employed. Components analysis confirms the best performance of IMERG‐F among the five SPEs in three different categories. All five SPEs feature increasing bias and root mean square difference (RMSD) with increasing daily gauge total precipitation, and such issue is less pronounced for IMERG‐F—as evidenced by the lowest bias and RMSD across all precipitation rates. Besides, compared to TMPA, IMERG products exhibit better accuracy in detecting real precipitation evens, especially for light‐to‐medium rain (<60 mm/day), but they do not demonstrate significant improvement in the assessment of severe over/underestimation. In the basin‐scale comparison, all five SPEs catch the key variation feature of basin‐averaged precipitation time series (except TMPA‐RT over Continental River Basin). Overall, IMERG‐F demonstrates the best performance over all nine basins despite the slight overestimation, followed by TMPA‐V7. IMERG‐E and IMERG‐L show performance close to or even better than TMPA‐V7 in terms of the correlation coefficient and RMSD.
Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function
Authors: Fagny Maud , Platig John , Kuijjer Marieke Lydia , Lin Xihong , Quackenbush John 
Published: December 2019

Abstract
Background
Genome-wide association studies (GWASes) have identified many noncoding germline single-nucleotide polymorphisms (SNPs) that are associated with an increased risk of developing cancer. However, how these SNPs affect cancer risk is still largely unknown.

Methods
We used a systems biology approach to analyse the regulatory role of cancer-risk SNPs in thirteen tissues. By using data from the Genotype-Tissue Expression (GTEx) project, we performed an expression quantitative trait locus (eQTL) analysis. We represented both significant cis- and trans-eQTLs as edges in tissue-specific eQTL bipartite networks.

Results
Each tissue-specific eQTL network is organised into communities that group sets of SNPs and functionally related genes. When mapping cancer-risk SNPs to these networks, we find that in each tissue, these SNPs are significantly overrepresented in communities enriched for immune response processes, as well as tissue-specific functions. Moreover, cancer-risk SNPs are more likely to be ‘cores’ of their communities, influencing the expression of many genes within the same biological processes. Finally, cancer-risk SNPs preferentially target oncogenes and tumour-suppressor genes, suggesting that they may alter the expression of these key cancer genes.

Conclusions
This approach provides a new way of understanding genetic effects on cancer risk and provides a biological context for interpreting the results of GWAS cancer studies.
Spatial proximity between T and PD-L1 expressing cells as a prognostic biomarker for oropharyngeal squamous cell carcinoma
Authors: Tsakiroglou Anna Maria , Fergie Martin , Oguejiofor Ken , Linton Kim , Thomson David , Stern Peter L. , Astley Susan , Byers Richard , West Catharine M. L. 
Published: December 2019

Abstract
Background
Fulfilling the promise of cancer immunotherapy requires novel predictive biomarkers to characterise the host immune microenvironment. Deciphering the complexity of immune cell interactions requires an automated multiplex approach to histological analysis of tumour sections. We tested a new automatic approach to select tissue and quantify the frequencies of cell-cell spatial interactions occurring in the PD1/PD-L1 pathway, hypothesised to reflect immune escape in oropharyngeal squamous cell carcinoma (OPSCC).

Methods
Single sections of diagnostic biopsies from 72 OPSCC patients were stained using multiplex immunofluorescence (CD8, PD1, PD-L1, CD68). Following multispectral scanning and automated regions-of-interest selection, the Hypothesised Interaction Distribution (HID) method quantified spatial proximity between cells. Method applicability was tested by investigating the prognostic significance of co-localised cells (within 30 μm) in patients stratified by HPV status.

Results
High frequencies of proximal CD8+ and PD-L1+ (HR 2.95, p = 0.025) and PD1+ and PD-L1+ (HR 2.64, p = 0.042) cells were prognostic for poor overall survival in patients with HPV negative OPSCC (n = 31).

Conclusion
The HID method can quantify spatial interactions considered to reflect immune escape and generate prognostic information in OPSCC. The new automated approach is ready to test in additional cohorts and its applicability should be explored in research and clinical studies.
Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration
Authors: Po’uha Sela T. , Le Grand Marion , Brandl Miriam B. , Gifford Andrew J. , Goodall Gregory J. , Khew-Goodall Yeesim , Kavallaris Maria 
Published: December 2019

AbstractBackgroundStathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin’s role on the metastatic process, we performed integrated mRNA–miRNA expression analysis to identify pathways regulated by stathmin.MethodsMiRNA and gene arrays followed by miRNA-target-gene integration were performed on stathmin-depleted neuroblastoma cells (CtrlshRNAvs. Stmn Seq2shRNA). The expression of the predicted target PTPN14 was evaluated by RT-qPCR, western blot and immunohistochemistry. Gene-silencing technology was used to assess the role of PTPN14 on proliferation, migration, invasion and signalling pathway.ResultsStathmin levels modulated the expression of genes and miRNA in neuroblastoma cells, leading to a deregulation of migration and invasion pathways. Consistent with gene array data, PTPN14 mRNA and protein expression were downregulated in stathmin- depleted neuroblastoma cells and xenografts. In two independent neuroblastoma cells, suppression of PTPN14 expression led to an increase in cell migration and invasion. PTPN14 and stathmin expression did not act in a feedback regulatory loop in PTPN14- depleted cells, suggesting a complex interplay of signalling pathways. The effect of PTPN14 on YAP pathway activation was cell-type dependent.ConclusionsOur findings demonstrate that stathmin levels can regulate PTPN14 expression, which can modulate neuroblastoma cell migration and invasion.
Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells
Authors: Wang Yajie , Lu Ting , Sun Guohuan , Zheng Yawei , Yang Shangda , Zhang Hongyan , Hao Sha , Liu Yanfeng , Ma Shihui , Zhang Houyu , Ru Yongxin , Gao Shaorong , Yen Kuangyu , Cheng Hui , Cheng Tao 
Published: December 2019

AbstractApplying somatic cell reprogramming strategies in cancer cell biology is a powerful approach to analyze mechanisms of malignancy and develop new therapeutics. Here, we test whether leukemia cells can be reprogrammed in vivo using the canonical reprogramming transcription factors-Oct4, Sox2, Klf4, and c-Myc (termed as OSKM). Unexpectedly, we discover that OSKM can eradicate leukemia cells and dramatically improve survival of leukemia-bearing mice. By contrast, OSKM minimally impact normal hematopoietic cells. Using ATAC-seq, we find OSKM induce chromatin accessibility near genes encoding apoptotic regulators in leukemia cells. Moreover, this selective effect also involves downregulation of H3K9me3 as an early event. Dissection of the functional effects of OSKM shows that Klf4 and Sox2 play dominant roles compared to c-Myc and Oct4 in elimination of leukemia cells. These results reveal an intriguing paradigm by which OSKM-initiated reprogramming induction can be leveraged and diverged to develop novel anti-cancer strategies.
Resolving the cause of recurrent Plasmodium vivax malaria probabilistically
Authors: Taylor Aimee R. , Watson James A. , Chu Cindy S. , Puaprasert Kanokpich , Duanguppama Jureeporn , Day Nicholas P. J. , Nosten Francois , Neafsey Daniel E. , Buckee Caroline O. , Imwong Mallika , White Nicholas J. 
Published: December 2019

AbstractRelapses arising from dormant liver-stage Plasmodium vivax parasites (hypnozoites) are a major cause of vivax malaria. However, in endemic areas, a recurrent blood-stage infection following treatment can be hypnozoite-derived (relapse), a blood-stage treatment failure (recrudescence), or a newly acquired infection (reinfection). Each of these requires a different prevention strategy, but it was not previously possible to distinguish between them reliably. We show that individual vivax malaria recurrences can be characterised probabilistically by combined modelling of time-to-event and genetic data within a framework incorporating identity-by-descent. Analysis of pooled patient data on 1441 recurrent P. vivax infections in 1299 patients on the Thailand–Myanmar border observed over 1000 patient follow-up years shows that, without primaquine radical curative treatment, 3 in 4 patients relapse. In contrast, after supervised high-dose primaquine only 1 in 40 relapse. In this region of frequent relapsing P. vivax, failure rates after supervised high-dose primaquine are significantly lower (∼3%) than estimated previously.
Overall electrochemical splitting of water at the heterogeneous interface of nickel and iron oxide
Authors: Suryanto Bryan H. R. , Wang Yun , Hocking Rosalie K. , Adamson William , Zhao Chuan 
Published: December 2019

AbstractEfficient generation of hydrogen from water-splitting is an underpinning chemistry to realize the hydrogen economy. Low cost, transition metals such as nickel and iron-based oxides/hydroxides have been regarded as promising catalysts for the oxygen evolution reaction in alkaline media with overpotentials as low as ~200 mV to achieve 10 mA cm−2, however, they are generally unsuitable for the hydrogen evolution reaction. Herein, we show a Janus nanoparticle catalyst with a nickel–iron oxide interface and multi-site functionality for a highly efficient hydrogen evolution reaction with a comparable performance to the benchmark platinum on carbon catalyst. Density functional theory calculations reveal that the hydrogen evolution reaction catalytic activity of the nanoparticle is induced by the strong electronic coupling effect between the iron oxide and the nickel at the interface. Remarkably, the catalyst also exhibits extraordinary oxygen evolution reaction activity, enabling an active and stable bi-functional catalyst for whole cell water-splitting with, to the best of our knowledge, the highest energy efficiency (83.7%) reported to date.