bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on energy storage participating in frequency modulation based on fuzzy partition coordinated control
Authors: Li Ping , Sun Feng , Liu Siqi , Wang Wende , Zhang Xiaotong , Ye Peng 
Published: December 2020

Abstract
Energy storage has the advantages of fast response and accurate power tracking when participates in frequency modulation. By dividing the Area Control Error (ACE) and battery’s State of Charge (SOC) into different regions, combining them with four different emergency frequency modulation states, this paper proposes a partition coordinated control strategy for energy storage to participate in frequency modulation. According to the regional interconnected system, the model of energy storage participating in power grid frequency modulation is built in MATLAB/Simulink. Based on the conventional control and the partition coordinated control, the frequency waveform analyzed. The results show that the energy storage participating in frequency modulation can effectively shorten the regulation time and reduce the frequency fluctuation. The fuzzy control used to optimize the partition coordinated control strategy to make the whole link have better frequency modulation ability.
A driving power with filter compensator for micro-positioning improvement of piezoelectric bimorph actuators
Authors: Chen Wei , Chen Yuansheng , Gu Cong , Zhao Pengcheng 
Published: December 2020

Abstract
To improve the micro-positioning accuracy of piezoelectric bimorph actuators, a driving power was designed with filter compensator. Amplifier modular was designed with high-voltage operational amplifier, and filter compensator modular is responsible for charge signal. Simulation results show that the output of filter compensator modular is proportional to the electric charge on the actuator. Experimental results indicate that the maximum error is 10μm without filter compensator modular, and reduced to 5μm with proposed driving power.
Lifetime Alcohol Use Influences the Association Between Future-Oriented Thought and White Matter Microstructure in Adolescents
Authors: Jones Scott A , Kazakova Natalia , Nagel Bonnie J 
Published: December 2020

Abstract

Aims
Future orientation, or the ability to plan ahead and anticipate consequences, is a capacity that develops during adolescence, yet its underlying neurobiology is unknown. Previous independent reports suggest that reduced future orientation and altered white matter microstructure are associated with greater alcohol use in adolescents; however, these effects have not been studied in conjunction. This study investigated the association between future orientation and white matter microstructure as a function of lifetime alcohol use.

Methods
Seventy-seven adolescents (46 female; 15-21 years of age) underwent diffusion weighted imaging (DWI) and completed a fifteen-item Future Orientation Questionnaire. Regression analyses assessed the association between self-reported lifetime alcohol use and future orientation, and the association between future orientation and white matter microstructure, as a function of lifetime alcohol use.

Results
Adolescents with more lifetime alcohol use demonstrated lower future orientation. Voxel-wise DWI analyses revealed two regions, bilateral posterior corona radiata (PCR), where greater future orientation was associated with lower mean diffusivity in those with little or no history of alcohol use; however, this association was diminished with increasing rates of lifetime alcohol use.

Conclusions
These findings replicate reports of reduced future orientation as a function of greater lifetime alcohol use and demonstrate an association between future orientation and white matter microstructure, in the PCR, a region containing afferent and efferent fibers connecting the cortex to the brain stem, which depends upon lifetime alcohol use. These findings provide novel information regarding the underlying neurobiology of future-oriented thought and how it relates to alcohol use.
Machine-OlF-Action: a unified framework for developing and interpreting machine-learning models for chemosensory research
Authors: Gupta Anku , Choudhary Mohit , Mohanty Sanjay Kumar , Mittal Aayushi , Gupta Krishan , Arya Aditya , Kumar Suvendu , Katyayan Nikhil , Dixit Nilesh Kumar , Kalra Siddhant , Goel Manshi , Sahni Megha , Singhal Vrinda , Mishra Tripti , Sengupta Debarka , Ahuja Gaurav 
Published: December 2020

Abstract

Summary
Machine Learning-based techniques are emerging as state-of-the-art methods in chemoinformatics to selectively, effectively and speedily identify biologically relevant molecules from large databases. So far, a multitude of such techniques have been proposed, but unfortunately due to their sparse availability, and the dependency on high-end computational literacy, their wider adaptation faces challenges, at least in the context of G-Protein Coupled Receptors (GPCRs)-associated chemosensory research. Here, we report Machine-OlF-Action (MOA), a user-friendly, open-source computational framework, that utilizes user-supplied SMILES (simplified molecular input line entry system) of the chemicals, along with their activation status, to synthesize classification models. MOA integrates a number of popular chemical databases collectively harboring approximately 103 million chemical moieties. MOA also facilitates customized screening of user-supplied chemical datasets. A key feature of MOA is its ability to embed molecules based on the similarity of their local neighborhood, by utilizing a state-of-the-art model interpretability framework LIME. We demonstrate the utility of MOA in identifying previously unreported agonists for human and mouse olfactory receptors OR1A1 and MOR174-9 by leveraging the chemical features of their known agonists and non-agonists. In summary, here we develop an ML-powered software playground for performing supervisory learning tasks involving chemical compounds.

Availability and implementation
MOA is available for Windows, Mac and Linux operating systems. It’s accessible at (https://ahuja-lab.in/). Source code, user manual, step-by-step guide and support is available at GitHub (https://github.com/the-ahuja-lab/Machine-Olf-Action). For results, reproducibility and hyperparameters, refer to Supplementary Notes.

Supplementary information
Supplementary data are available at Bioinformatics online.
PhyloCorrelate: inferring bacterial gene–gene functional associations through large-scale phylogenetic profiling
Authors: Tremblay Benjamin J -M , Lobb Briallen , Doxey Andrew C 
Published: December 2020

Abstract

Motivation
Statistical detection of co-occurring genes across genomes, known as ‘phylogenetic profiling’, is a powerful bioinformatic technique for inferring gene–gene functional associations. However, this can be a challenging task given the size and complexity of phylogenomic databases, difficulty in accounting for phylogenetic structure, inconsistencies in genome annotation and substantial computational requirements.

Results
We introduce PhyloCorrelate—a computational framework for gene co-occurrence analysis across large phylogenomic datasets. PhyloCorrelate implements a variety of co-occurrence metrics including standard correlation metrics and model-based metrics that account for phylogenetic history. By combining multiple metrics, we developed an optimized score that exhibits a superior ability to link genes with overlapping GO terms and KEGG pathways, enabling gene function prediction. Using genomic and functional annotation data from the Genome Taxonomy Database and AnnoTree, we performed all-by-all comparisons of gene occurrence profiles across the bacterial tree of life, totaling 154 217 052 comparisons for 28 315 genes across 27 372 bacterial genomes. All predictions are available in an online database, which instantaneously returns the top correlated genes for any PFAM, TIGRFAM or KEGG query. In total, PhyloCorrelate detected 29 762 high confidence associations between bacterial gene/protein pairs, and generated functional predictions for 834 DUFs and proteins of unknown function.

Availabilityand implementation
PhyloCorrelate is available as a web-server at phylocorrelate.uwaterloo.ca as well as an R package for analysis of custom datasets. We anticipate that PhyloCorrelate will be broadly useful as a tool for predicting function and interactions for gene families.

Supplementary information
Supplementary data are available at Bioinformatics online.
Plant Extract and Herbal Products as Potential Source of Sorbent for Analytical Purpose: An Experimental Study of Morphine and Codeine Determination Using HPLC and LC–MSMS
Authors: Ghorani-Azam Adel , Balali-Mood Mahdi , Khatami Seyed-Mola , Asoodeh Ahmad , Es’haghi Zarrin , Riahi-Zanjani Bamdad 
Published: December 2020

Abstract
Solid-phase microextraction (SPME) is an analytical method for microextraction of analytes, in which the analytes bind to the sorbent on the surface of the SPME fiber. Many types of chemical agents are used as sorbent; however, many of these sorbents cause secondary contamination or are not cost-effective. Here, aqueous extract of Ferula gummosa was evaluated as potential source of sorbent for simultaneous microextraction of morphine and codeine. For this purpose, multiwalled carbon nanotubes were carboxylated with H2SO4/HNO3 (3:1) and then functionalized with aqueous extract of F. gummosa. Functionalization was confirmed by Fourier transform infrared and Raman spectroscopy measurements as well as scanning electron microscopy analysis. Porous polypropylene hollow fibers were filled with the functionalized carbon nanotubes (CNTs) and used for analyte extraction in urine sample at 40°C and pH 6 for 2 min. Reversed-phase high-performance liquid chromatography (RP-HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis showed that the fiber could preconcentrate 1 ng/mL of morphine and 0.75 ng/mL codeine in urine sample and was successfully used for 30 times with no significant loss in the extraction efficiency. Limit of detection (LOD) and limit of quantification (LOQ) for morphine were 1 and 3.3 ng/mL, respectively. LOD and LOQ for codeine were determined 0.75 and 2.47 ng/mL, respectively. Recovery of the fiber was 80% and 93% for morphine and codeine, respectively. SPME fiber using extract of F. gummosa plant was used for the detection of a small amount of morphine in urine sample. Therefore, plants can be considered as abundant and cheap sources of sorbent for various analytical purposes.
Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin inClione limacinaCentral Pattern Generator Swim Interneurons
Authors: Pirtle Thomas J , Satterlie Richard A 
Published: December 2020

SynopsisBoth nitric oxide (NO) and serotonin (5HT) mediate swim acceleration in the marine mollusk, Clione limacina. In this study, we examine the role that the second messenger, cyclic guanosine monophosphate (cGMP), plays in mediating NO and 5HT-induced swim acceleration. We observed that the application of an analog of cGMP or an activator of soluble guanylyl cyclase (sGC) increased fictive locomotor speed recorded from Pd-7 interneurons of the animal’s locomotor central pattern generator. Moreover, inhibition of sGC decreased fictive locomotor speed. These results suggest that basal levels of cGMP are important for slow swimming and that increased production of cGMP mediates swim acceleration in Clione. Because NO has its effect through cGMP signaling and because we show herein that cGMP produces cellular changes in Clione swim interneurons that are consistent with cellular changes produced by 5HT application, we hypothesize that both NO and 5HT function via a common signal transduction pathway that involves cGMP. Our results show that cGMP mediates NO-induced but not 5HT-induced swim acceleration in Clione.
The national landscape of culminating experiences in master’s programs in health and biomedical informatics
Authors: Cox Suzanne Morrison , Johnson Stephen B , Shiu Eva , Boren Sue 
Published: December 2020

Abstract
Health and biomedical informatics graduate-level degree programs have proliferated across the United States in the last 10 years. To help inform programs on practices in teaching and learning, a survey of master’s programs in health and biomedical informatics in the United States was conducted to determine the national landscape of culminating experiences including capstone projects, research theses, internships, and practicums. Almost all respondents reported that their programs required a culminating experience (97%). A paper (not a formal thesis), an oral presentation, a formal course, and an internship were required by ≥50% programs. The most commonly reported purposes for the culminating experience were to help students extend and apply the learning and as a bridge to the workplace. The biggest challenges were students’ maturity, difficulty in synthesizing information into a coherent paper, and ability to generate research ideas. The results provide students and program leaders with a summary of pedagogical methods across programs.
Graded dietary resistant starch concentrations on apparent total tract macronutrient digestibility and fecal fermentative end products and microbial populations of healthy adult dogs
Authors: Beloshapka Alison N , Cross Tzu-Wen L , Swanson Kelly S 
Published: December 2020

AbstractResistant starch (RS) is fermentable by gut microbiota and effectively modulates fecal short-chain fatty acid concentrations in pigs, mice, and humans. RS may have similar beneficial effects on the canine gut but has not been well studied. The objective of this study was to evaluate the effects of 0%, 1%, 2%, 3%, and 4% dietary RS (Hi-maize 260) on apparent total tract macronutrient digestibility, fecal characteristics, fermentative end-product concentrations, and microbiota of healthy adult dogs. An incomplete 5 × 5 Latin square design with seven dogs and five experimental periods was used, with each treatment period lasting 21 d (days 0 to 17 adaptation; days 18 to 21 fresh and total fecal collection) and each dog serving as its own control. Seven dogs (mean age = 5.3 yr; mean body weight = 20 kg) were randomly allotted to one of five treatments formulated to be iso-energetic and consisting of graded amounts of 100% amylopectin cornstarch, RS, and cellulose and fed as a top dressing on the food each day. All dogs were fed the same amount of a basal diet throughout the study, and fresh water was offered ad libitum. The basal diet contained 6.25% RS (dry matter [DM] basis), contributing approximately 18.3 g of RS/d based on their daily food intake (292.5 g DM/d). Data were evaluated for linear and quadratic effects using SAS. The treatments included 0%, 1%, 2%, 3%, and 4% of an additional RS source. Because Hi-maize 260 is approximately 40% digestible and 60% indigestible starch, the dogs received the following amounts of RS daily: 0% = 18.3 g (18.3 + 0 g), 1% = 20.1 g (18.3 + 1.8 g), 2% = 21.9 g (18.3 + 3.6 g), 3% = 23.7 g (18.3 + 5.4 g), and 4% = 25.5 g (18.3 + 7.2 g). Apparent total tract DM, organic matter, crude protein, fat, and gross energy digestibilities and fecal pH were linearly decreased (P &lt; 0.05) with increased RS consumption. Fecal output was linearly increased (P &lt; 0.05) with increased RS consumption. Fecal scores and fecal fermentative end-product concentrations were not affected by RS consumption. Although most of the fecal microbial taxa were not altered, Faecalibacterium were increased (P &lt; 0.05) with increased RS consumption. The decrease in fecal pH and increase in fecal Faecalibacterium would be viewed as being beneficial to gastrointestinal health. Although our results seem to indicate that RS is poorly and/or slowly fermentable in dogs, the lack of observed change may have been due to the rather high level of RS contained in the basal diet.
The Psychology of Marginal Utility
Authors: Li Xilin , Hsee Christopher K 
Published: December 2020

Abstract
That wealth has diminishing marginal utility is a fact of life, and that people be sensitive to their current level of wealth when deciding whether to pursue additional wealth is a requirement of rational choice. A series of experiments, spanning diverse contexts, reveal marginal-utility neglect—that people are rather insensitive to their current wealth when deciding how much effort to expend to acquire a monetary reward (e.g., how long to walk to claim a voucher). Moreover, the experiments demonstrate that a marginal-utility-prompting manipulation, which prompts people to consider their current wealth and their need for the reward given their current wealth, produces a significant sensitization effect—making financially richer (vs. less rich) individuals less (vs. more) willing to seek the reward. This manipulation is more effective than either prompting people to consider their current wealth alone or consider their need for the reward alone, suggesting that marginal-utility prompting does not merely draw people’s attention to their current wealth or merely draw their attention to their need for the reward, but links the two elements. This research elucidates the psychology of marginal utility and yields implications beyond the pursuit of monetary rewards.
The Indirect Purchaser Rule and Private Enforcement of Antitrust Law: A Reassessment
Authors: Smith Spencer 
Published: December 2020

Abstract
Despite broad statutory language authorizing “any person” injured by an antitrust law violation to sue for damages, the Supreme Court of the United States has construed that language to bar antitrust damages claims by indirect purchasers, such as consumers two or more steps removed from antitrust violators. The Court and some scholars have justified the indirect purchaser rule on the ground that assigning direct purchasers exclusive rights to recover antitrust damages increases the likelihood of suit. But this article presents new evidence that the rule reduced private antitrust litigation by twenty percent. It argues that the rule should be abandoned, consistent with the statutory text.
Profiles After Acute Traumatic Injury: The Non-battle Injury Impact on Readiness at a Single Military Treatment Facility
Authors: Aranda Marcos , Poloni Dana , Coffin Elisabeth , Hendren Bryan 
Published: December 2020

ABSTRACT

Introduction
Physical profiling is critical to the individual medical readiness of all military service members. This classification system provides detailed information about an individual’s functional abilities. Profile information is used in determining whether a service member is medically deployable or non-deployable. Limited research has been conducted on the impact of acute traumatic injuries on duty status and profiles in the non-deployed setting. The purpose of this study was to characterize injured service members presenting to a CONUS MTF emergency department whose acute traumatic injury resulted in a profile.

Materials and Methods
A retrospective review of patients who presented to the Dwight D. Eisenhower Army Medical Center emergency department with traumatic injuries from January 1, 2019, to December 31, 2019, was performed. Patients were identified by searching electronic encounter records for trauma-specific ICD-10 codes. Returned patient records were then reviewed for active duty status, branch, age, gender, rank, mechanism, protective equipment, substance use, procedures, and disposition. Profiles of soldiers were reviewed for indication and duration. Patients with profiles were compared to those without profiles. Correlation with age was determined by t-test, correlation with profile length was determined by ANOVA, and correlation with the remaining categorical variables was determined with chi-squared analysis.

Results
Eight hundred and thirty-two service members were reviewed. One hundred and eight (13%) soldiers had a profile. Patients were 23.2% female with no difference between the two groups. Patients were an average of 28.7 years old. The most common mechanisms were physical training (PT) (33.1%) and falls (12.9%). Physical training and motor vehicle collisions were more common in the profile group. Combatives and crush injuries of the hand were less common in the profile group. Major procedures were more common in the profile group, and minor procedures were less common. Admissions, quarters, immediate referrals, and release without limitations were more common in the profile group. The mean duration of profiles was 48.9 days, and 7.4% were permanent.

Conclusions
Non-battle injuries in the garrison setting are a significant threat to readiness. This analysis of acute traumatic injuries suggests that mechanism of injury was similar to previous reports with PT and falls being most common. Interventions should be targeted at PT and motor vehicle collisions as these were more common in the profile group. This series is also similar to previous reports that extremity injuries are the most common cause of profiles. However, TBIs were more common in our analysis. Further research that encompasses all garrison MTF acute traumatic injuries is needed to define the true impact on readiness and guide development of injury prevention strategies.
Fifty years of University-industry collaboration: a global bibliometrics overview
Authors: Bastos Elisa Cordeiro , Sengik Aline Rossales , Tello-Gamarra Jorge 
Published: December 2020

Abstract
This article presents a bibliometric overview of publications on university-industry collaboration (UIC) from the last fifty years (1969–2018). Among the results that were obtained, three main ones come to light. First, this article presents a complete panorama of UIC research from the past fifty years. Secondly, we were able to note that the UIC research trajectory can be divided into four generations which are represented by different phases: the discovery phase (1969–1979), the development phase (1980–1999), the expansion phase (2000–2010) and the consolidation phase (2011–2018). Furthermore, the connections and evolution pertaining to these four generations were identified. The third result was the identification of eight research trends within the UIC context: ‘UIC topics’ (especially: motivation, channels, barriers and results), ‘engineering education’, ‘societies and institutions’, ‘knowledge transfer’, ‘innovation’, ‘entrepreneurial university’, ‘sustainability’ and ‘developing countries’.
Save the Economy, Liberty, and Yourself: Christian Nationalism and Americans’ Views on Government COVID-19 Restrictions
Authors: Perry Samuel L , Whitehead Andrew L , Grubbs Joshua B 
Published: December 2020

AbstractDuring the COVID-19 pandemic, state and local governments implemented lockdown restrictions that were tremendously polarizing. Those on the cultural and political left supported restrictions hoping to protect the vulnerable, while those on the cultural and political right challenged restrictions citing threats to the economy and liberty. We theorize that libertarian and authoritarian impulses within Christian nationalism undergirded much of the resistance to government restrictions. Analyzing national panel data collected before and during the pandemic, we find Christian nationalism is either the first or second strongest predictor that Americans prioritize the economy and liberty and deprioritize the vulnerable when asked about government restrictions. Religiosity works in the opposite direction, however. Findings underscore the centrality of Christian nationalism as an ideological driver of far-right discourse shaping COVID-19 responses.