bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary Study of Harmonic Generated by Household Appliances
Authors: Nisja I , Hardi S. , Mirzazoni  , Hidayat  
Published: December 2020

Abstract
This paper is preliminary study with focused on the harmonics generated by household appliances. There are only several household appliances that considered in this paper are television set, laptop computer and compact fluorescent lamp (CFL). To measure the input current, the measurement equipment was installed at the input side of equipment under the test. The important parameters that have been recorded are individual harmonic currents, total harmonics distortion, power factor, input current and input voltage wave form. From the measurement results, television sets, laptop computers and CFLs have been found generate the THDi of 177%, 273.66% and 154.2% respectively. If it is widely used in residential areas, it is likely that there will be increased harmonic distortion in the electric power distribution system. Because this research is still in its early stages, at the end of this research it will be known how much harmonics is generated by the load in the residential area. If amount of harmonics generated by the housing load that exceeds the limit, so the next step of this research a harmonics filter design will carried out.
Productivity Improvement Through Innovation of Production Facilities in MSMEs
Authors: Mufti D , Mahjoedin Y , Iksan A 
Published: December 2020

Abstract
Sakura cake is a traditional food from District Cangkiang, Agam Regency, West Sumatra. This cake has been marketed to Bukittingi, Padang and has been used as a typical food from West Sumatra. In Cangkiang there are a number of similar Sakura cake micro-businesses and still use coconut shell as a moulding cake. However, the production capacity with coconut shell is still low even unable to meet demand. In addition, the use of coconut shell can risk injury to workers. So an innovation is made on the tools that are already on the market and can be used as a substitute for it. In research on productivity calculation using the Objective Matrix (OMAX) method by using production data for six periods. The productivity criteria measured are the use of raw materials, the use of working hours, fuel consumption and electricity use. The results of this study found that achieving the highest score was found in the criteria for use of working hours, at level 9, which was reached at the end of the survey period.
WaterDistribution in the Flow Field of the BipolarPlate on the CathodeSide of the PEM FuelCell
Authors: Mulyazmi  , Marthynis M , Safitri F R , Sari N G 
Published: December 2020

Abstract
The presence of water in the flow field greatly affects the performance of PEM fuel cell. One of the problems is caused by the water imbalance in the PEM fuel cell. If the water content is too high it causes flooding in the PEM fuel cell stack. As a result, the distribution flow of raw materials (hydrogen and oxygen) flowing into the stack is blocked. Conversely, if it is too dry it will cause the membrane to crack. Both cases resulted in a decrease in the performance of the PEM fuel cell system. The method used for water management in the flow field of a bipolar plate flow Computating Fluids Dynamics (CFD) software. The results showed that the highest water content occurred in the spiral flow field at a flow rate of 4 x 10-8 kg/s with a water content of 0.75 g/g. The lowest water content occurs in the multiple channel serpentine flow field at a flow rate of 4 x 10-8 kg/s with the water content of 0.47 g/g. In this condition the performance of PEM fuel cell is relatively stable in the single channel serpentine flow field with a flow rate of 4 x 10-8 kg/s and a depth of 0.3 mm because the formation of water is insignificant compared to using other flow fields.
Linear and Non-linear Regression Analysis for the Kinetics of [AuCl4]- Removal by p-Hydroxybenzoate intercalated Mg/Al-Hydrotalcite
Authors: Hasnowo L A , Santosa S J , Rusdiarso B 
Published: December 2020

Abstract
The best fit equations of linear and non-linear forms of the two widely used kinetic models, namely pseudo-first-order (PFO) and pseudo-second-order (PSO) equations, were compared in this study. The experimental kinetics of [AuCl4]−removal by p-hydroxybenzoate intercalated Mg/Al-hydrotalcite was used for this research. R2
coefficient was employed as error analysis methods to determine the best-fitting equations. The results show that the non-linear form was better at best-fitting than the linear form. The experimental kinetics may have been distorted by linearization of the linear kinetic equations, and thus, the non-linear forms of kinetic equations should be primarily used to obtain the adsorption parameters.
Material Density of Composite hydroxyapatite Bovine Bone-Borosilicate formed by Compaction and Sintering Techniques
Authors: Burmawi  , Syahroom A , Jamarun N , Arief S , Gunawarman  
Published: December 2020

Abstract
Hydroxyapatite Ca10 (PO4) 6 (OH) 2 is a calcium compound whose chemical composition is similar to human bone minerals. In this study, hydroxyapatite was formed into a composite material by adding borosilicate (borax and silica). For the formation of this composite material, the Hydroxyapatite borosilicate composition has been adjusted, namely: 90:10, 85:15, 80:20, 75:25, 70:30 wt.%. The samples were made with different compacting forces, namely 5 KN, 15 KN, and 25 KN with a sintering temperature of 800 ° C. 0.003734 gr / mm3. While the lowest density value is found in the composition 75:25 Wt.%, The compacting force is 5 KN with a value of 0.002436 gr / mm3. The decrease in the density value is influenced by the composition and compaction force applied. The greater the borosilicate composition, the lower the density. Meanwhile, the greater the compacting force applied, the density will increase.
Performance Study ff Increasing Power Plant Efficiency by Reducing Condenser Pressure in Teluksirih Power Plant
Authors: Kaidir  , Burmawi  , Mulyanef  , Muhammad DG 
Published: December 2020

Abstract
Research on increasing the efficiency of power plant needs to be done because the cost of producing electricity is quite large. The biggest cost of the electricity production process is the cost of fuel. One way to reduce fuel consumption is to reduce the pressure of the condenser. By decreasing the condenser pressure, the steam turbine load will increase, and the efficiency of the power plant increases. Therefore, it is necessary to conduct research to analysis power plant efficiency, analysis the relationship between condenser pressure and powerplant efficiency, determine coal usage requirements. There sulting efficiency will be related to the energy generated. The higher the energy generated; the efficiency will also increase.
Identification of haploinsufficient genes from epigenomic data using deep forest
Authors: Yang Yuning , Li Shaochuan , Wang Yunhe , Ma Zhiqiang , Wong Ka-Chun , Li Xiangtao 
Published: December 2020

AbstractHaploinsufficiency, wherein a single allele is not enough to maintain normal functions, can lead to many diseases including cancers and neurodevelopmental disorders. Recently, computational methods for identifying haploinsufficiency have been developed. However, most of those computational methods suffer from study bias, experimental noise and instability, resulting in unsatisfactory identification of haploinsufficient genes. To address those challenges, we propose a deep forest model, called HaForest, to identify haploinsufficient genes. The multiscale scanning is proposed to extract local contextual representations from input features under Linear Discriminant Analysis. After that, the cascade forest structure is applied to obtain the concatenated features directly by integrating decision-tree-based forests. Meanwhile, to exploit the complex dependency structure among haploinsufficient genes, the LightGBM library is embedded into HaForest to reveal the highly expressive features. To validate the effectiveness of our method, we compared it to several computational methods and four deep learning algorithms on five epigenomic data sets. The results reveal that HaForest achieves superior performance over the other algorithms, demonstrating its unique and complementary performance in identifying haploinsufficient genes. The standalone tool is available at https://github.com/yangyn533/HaForest.
Developing a patient-centred tool for pain measurement and evaluation in autosomal dominant polycystic kidney disease
Authors: El-Damanawi Ragada , Lee Michael , Harris Tess , Cowley Laura B , Scholtes Ingrid , Bond Simon , Sandford Richard N , Wilkinson Ian B , Casteleijn Niek F , Hogan Marie C , Karet Frankl Fiona E , Hiemstra Thomas F 
Published: December 2020

AbstractBackgroundPain affects 60% of the autosomal dominant polycystic kidney disease (ADPKD) population. Despite being an early and debilitating symptom, it is poorly characterized and management is suboptimal. This study aimed to develop an ADPKD-specific pain assessment tool (APAT) to facilitate pain research.MethodsFollowing a systematic review of PATs used in ADPKD studies and against international recommendations for pain trials, our multi-disciplinary team of clinical experts and patients constructed an ADPKD-pain conceptual framework of key pain evaluation themes. We compiled a new APAT covering domains prioritized within our framework using components of questionnaires validated in other chronic pain disorders. The APAT was administered longitudinally within a randomized high-water intake trial (NCT02933268) to ascertain feasibility and provide pilot data on ADPKD pain.ResultsThirty-nine ADPKD participants with chronic kidney disease Stages 1–4 provided 129 APAT responses. Each participant completed a median of 3 (range 1–10) assessments. Respondents’ mean ± standard deviation age was 47 ± 13 years; 59% (23) were female; and 69% (27) had enlarged kidneys with median time from diagnosis 14.2 (interquartile range 7.0–25.9) years. Pain (52%) and associated analgesic use (29%) were common. Pain severity was associated with increasing age [odds ratio (OR) = 1.07, P = 0.009], female gender (OR = 4.34, P = 0.018), estimated glomerular filtration rate &lt;60 mL/min/1.73 m2 (OR = 5.45, P = 0.021) and hypertension (OR = 12.11, P = 0.007), but not with kidney size (P = 0.23). The APAT achieved good internal consistency (Cronbach’s alpha coefficient = 0.91) and test–retest reliability (domain intra-class correlation coefficients ranging from 0.62 to 0.90).ConclusionsThe APAT demonstrated good acceptability and reliability, and following further validation in a larger cohort could represent an invaluable tool for future ADPKD pain studies.
Interplay between right atrial function and liver stiffness in adults with repaired right ventricular outflow obstructive lesions
Authors: Li Vivian Wing-Yi , So Edwina Kam-Fung , Li Wenxi , Chow Pak-Cheong , Cheung Yiu-Fai 
Published: December 2020

Abstract

Aims
This study determined the associations between right atrial (RA) and right ventricular (RV) mechanics and liver stiffness in adults with repaired tetralogy of Fallot (TOF), pulmonary atresia with intact ventricular septum (PAVIS), and pulmonary stenosis (PS).

Methods and results
Ninety subjects including 26 repaired TOF, 24 PAIVS, and 20 PS patients and 20 controls were studied. Hepatic shear wave velocity and tissue elasticity (E), measures of liver stiffness, were assessed by two-dimensional shear wave elastography, while RA and RV mechanics were assessed by speckle tracking echocardiography. Deformation analyses revealed worse RV systolic strain and strain rate, and RA peak positive and total strain, and strain rates at ventricular systole and at early diastole in all of the patient groups compared with controls (all P &lt; 0.05). Compared with controls, all of the patient groups had significantly greater shear wave velocity and hepatic E-value (all P &lt; 0.05). Shear wave velocity and hepatic E-value correlated negatively with RV systolic strain rate, and RA positive strain, total strain, and strain rate at ventricular systole and at early diastole (all P &lt; 0.05). Multivariate analyses revealed RA strain rate at early diastole (P = 0.015, P &lt; 0.001), maximum RA size (P &lt; 0.001, P &lt; 0.001), and severity of pulmonary regurgitation (P = 0.05, Pp = 0.014) as significant correlates of shear wave velocity and hepatic E-value.

Conclusion
In adults with repaired TOF, PAIVS, and PS, RA dysfunction and pulmonary regurgitation are associated with liver stiffness.
Two zebras and a cardiac arrest: a case report of concomitant Brugada syndrome and an anomalous coronary artery
Authors: Bates Alexander , Ullah Waqas , Wilkinson James , Shambrook James 
Published: December 2020

Abstract

Background
Discovering concomitant diagnoses results in a challenge to determine the true cause of a patient’s presentation. Evaluating this fully is vital to plan appropriate and avoid inappropriate therapy.

Case summary
A 55-year-old gentleman presents in cardiac arrest whilst watching an unusual occurrence of England dominating a Football World Cup game vs. Panama in 2018. Diagnostic coronary angiography discovered an anomalous right coronary artery from the opposite sinus (R-ACAOS), but clinical suspicion this was incidental lead to a further diagnosis of Type 1 Brugada Syndrome (BrS) following a positive Ajmaline provocation challenge. Risk stratification of these two zebras using computed tomography coronary angiography (CTCA), Cardiac magnetic resonance imaging (CMRI), Exercise Stress Echocardiography was performed and following a multi-disciplinary meeting, BrS was felt to be the primary diagnosis. The patient received a secondary prevention implantation of a cardiac defibrillator and avoided cardiac surgery.

Discussion
Diagnosing a rare condition does not necessarily mean it is the cause of a patient’s presentation and should not end the investigative process. Right coronary artery from the opposite sinus rarely causes cardiac arrest in middle age and is typically associated with peak exercise. Type 1 BrS is associated with cardiac arrest with vagal activity, perhaps such as England winning a World Cup game! Clinical correlation and risk stratification is required for suspected incidental findings.
Re-entrant ventricular tachycardia as a complication of ablation of idiopathic ventricular premature beats from the right outflow tract: a case report
Authors: Tran Van Nam , Rotman Samuel , Carroz Patrice , Pruvot Etienne 
Published: December 2020

Abstract

Background
We report an unusual case of non-sustained ventricular tachycardia (NSVT) from the epicardial part of the right ventricular outflow tract (RVOT).

Case summary
A 37-year-old woman who underwent in 2006 an ablation for idiopathic ventricular premature beats (VPBs) from the RVOT presented with pre-syncopal NSVT in 2016. A cardiac workup showed no coronary disease, normal biventricular function, and no enhancement on cardiac magnetic resonance imaging. A metabolic positron emission tomography scan excluded inflammation. Biopsies revealed normal desmosomal proteins. An endocardial mapping revealed an area of low voltage potential (&lt;0.5 mV) at the antero-septal aspect of the RVOT corresponding to the initial site of ablation from 2006. Activation mapping revealed poor prematurity and pace-mapping showed unsatisfactory morphologies in the RVOT, the left ventricle outflow tract and the right coronary cusp. An epicardial map revealed a low voltage area at the antero-septal aspect of the RVOT with fragmented potentials opposite to the endocardial scar. Pace-mapping demonstrated perfect match. An NSVT was induced and local electrocardiogram showed mid-diastolic potentials. Ablation was applied epicardially and endocardially without any complication. The patient was arrhythmia free at 4-year follow-up.

Discussion
Cardiac workup allowed to exclude specific conditions such as arrhythmogenic cardiomyopathy, tetralogy of Fallot, sarcoidosis, or myocarditis as a cause for NSVT from the RVOT. The epi and endocardial map showed residual scar subsequent to the first ablation which served as substrate for the re-entrant NSVT. This is the first case which describes NSVT from the epicardial RVOT as a complication from a previous endocardial ablation for idiopathic VPB.
Biodiversity and oenological attitude of Saccharomyces cerevisiae strains isolated in the Montalcino district: biodiversity of S. cerevisiae strains of Montalcino wines
Authors: Guzzon Raffaele , Roman Tomas , Larcher Roberto , Francesca Nicola , Guarcello Rosa , Moschetti Giancarlo 
Published: December 2020

ABSTRACT
The biodiversity of Saccharomyces cerevisiae was studied in the Montalcino area (Italy). Two wineries were involved in the study, which compared the genotypic and oenological characteristics of the S. cerevisiae strains isolated in spontaneous fermentations. After isolation yeasts were identified by 26S rRNA gene sequence analysis, and S. cerevisiae strains were characterized through interdelta sequence analysis (ISA). Oenological tests were performed in synthetic grape must by varying the magnitude of the main wine-imiting factors. The evolution of alcoholic fermentation was monitored by measuring sugar consumption and flow cytometry. The results revealed the prevalence of S. cerevisiae from the third day of fermentation and the presence of a wide range of S. cerevisiae strains having ISA profiles characteristic of each winery. From an oenological point of view, the features of such strains, in terms of resistance to wine-limiting factors, seemed to be linked to the main oenological variables applied in the production process of each winery. Extreme fermentation temperatures and copper residues are the variables that mostly depress the yeast population, in terms of fermentation rate and cell viability. Flow cytometry revealed the different impact of limiting factors on the viability of yeast by the quantification of the ratio between live/dead yeast cells of each strain, suggesting different mechanisms of inhibition, for instance stuck of cell growth or cell killing, in response to the different stress factors.
Video-based learning to enhance teaching of practical microbiology
Authors: Lacey Katrina , Wall J Gerard 
Published: December 2020

ABSTRACT
Video-based learning is an increasingly important methodology in higher education and has particular value in practical teaching. In order to enhance learning and promote student engagement in our undergraduate microbiology programme, we designed and produced a suite of teaching videos which demonstrate laboratory techniques core to the syllabus. The methods were demonstrated by Ph.D. students and the professionally-produced videos were made widely available via the free YouTube channel Microbiology teaching videos at NUI Galway (https://www.youtube.com/channel/UCsP4xz5aq7sWfR9eXSCd_QQ/), which accumulated over 40 000 views across 47 countries in its first 15 months online. A survey of students who used the videos in their teaching and learning identified a greatly increased understanding of experimental principles and ability to carry out techniques; greater engagement with practical teaching sessions; particular benefits for visual learners; and increased confidence in teaching and in communicating science amongst undergraduate teaching assistants. The videos will be central to microbiology teaching at NUI Galway over the coming decade and will benefit many third-level institutions exploring online and blended learning approaches in the coming years.
Mutational Pressure Drives Differential Genome Conservation in Two Bacterial Endosymbionts of Sap-Feeding Insects
Authors: Waneka Gus , Vasquez Yumary M , Bennett Gordon M , Sloan Daniel B 
Published: December 2020

Abstract
Compared with free-living bacteria, endosymbionts of sap-feeding insects have tiny and rapidly evolving genomes. Increased genetic drift, high mutation rates, and relaxed selection associated with host control of key cellular functions all likely contribute to genome decay. Phylogenetic comparisons have revealed massive variation in endosymbiont evolutionary rate, but such methods make it difficult to partition the effects of mutation versus selection. For example, the ancestor of Auchenorrhynchan insects contained two obligate endosymbionts, Sulcia and a betaproteobacterium (BetaSymb; called Nasuia in leafhoppers) that exhibit divergent rates of sequence evolution and different propensities for loss and replacement in the ensuing ∼300 Ma. Here, we use the auchenorrhynchan leafhopper Macrosteles sp. nr. severini, which retains both of the ancestral endosymbionts, to test the hypothesis that differences in evolutionary rate are driven by differential mutagenesis. We used a high-fidelity technique known as duplex sequencing to measure and compare low-frequency variants in each endosymbiont. Our direct detection of de novode novo mutations reveals that the rapidly evolving endosymbiont (Nasuia) has a much higher frequency of single-nucleotide variants than the more stable endosymbiont (Sulcia) and a mutation spectrum that is potentially even more AT-biased than implied by the 83.1% AT content of its genome. We show that indels are common in both endosymbionts but differ substantially in length and distribution around repetitive regions. Our results suggest that differences in long-term rates of sequence evolution in Sulcia versus BetaSymb, and perhaps the contrasting degrees of stability of their relationships with the host, are driven by differences in mutagenesis.
Urinary metabolite quantitative trait loci in children and their interaction with dietary factors
Authors: Calvo-Serra Beatriz , Maitre Léa , Lau Chung-Ho E , Siskos Alexandros P , Gützkow Kristine B , Andrušaitytė Sandra , Casas Maribel , Cadiou Solène , Chatzi Leda , González Juan R , Grazuleviciene Regina , McEachan Rosemary , Slama Rémy , Vafeiadi Marina , Wright John , Coen Murieann , Vrijheid Martine , Keun Hector C , Escaramís Geòrgia , Bustamante Mariona 
Published: December 2020

AbstractHuman metabolism is influenced by genetic and environmental factors. Previous studies have identified over 23 loci associated with more than 26 urine metabolites levels in adults, which are known as urinary metabolite quantitative trait loci (metabQTLs). The aim of the present study is the identification for the first time of urinary metabQTLs in children and their interaction with dietary patterns. Association between genome-wide genotyping data and 44 urine metabolite levels measured by proton nuclear magnetic resonance spectroscopy was tested in 996 children from the Human Early Life Exposome project. Twelve statistically significant urine metabQTLs were identified, involving 11 unique loci and 10 different metabolites. Comparison with previous findings in adults revealed that six metabQTLs were already known, and one had been described in serum and three were involved the same locus as other reported metabQTLs but had different urinary metabolites. The remaining two metabQTLs represent novel urine metabolite-locus associations, which are reported for the first time in this study [single nucleotide polymorphism (SNP) rs12575496 for taurine, and the missense SNP rs2274870 for 3-hydroxyisobutyrate]. Moreover, it was found that urinary taurine levels were affected by the combined action of genetic variation and dietary patterns of meat intake as well as by the interaction of this SNP with beverage intake dietary patterns. Overall, we identified 12 urinary metabQTLs in children, including two novel associations. While a substantial part of the identified loci affected urinary metabolite levels both in children and in adults, the metabQTL for taurine seemed to be specific to children and interacted with dietary patterns.