bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive values of multiple serum biomarkers in women with suspected preeclampsia: a prospective study
Authors: Wang Jing , Hu Honghai , Liu Xiaowei , Zhao Shenglong , Zheng Yuanyuan , Chen Lu , Zhang Chunhong , Xie Xin , Zhong Junhui , Dong Ying , Liu Jingrui , Lu Yifan , Zhao Zhen , Zhai Yanhong , Zhao Juan , Cao Zheng 
Published: June 2020

Abstract
Background

Early preeclampsia (PE) prediction has been shown to improve the maternal and fetal outcomes in pregnancy. We aimed to evaluate the PE prediction values of a series of serum biomarkers.
Methods

The singleton pregnant women with PE-related clinical and/or laboratory presentations were recruited and had the blood drawn at their first visits. The prospective cohort was further divided into the PE-positive and PE-negative groups based on the follow-up results. The following markers were tested with the collected serum samples: sFlt-1, PlGF, M, tPAI-C, compliment factors C1q, B, H, BUN, GlyFn, PAPP-A2, BUN, Cre, UA and Cysc.
Results

Totally 196 women suspected for PE were recruited with follow-up medical records. Twenty-five percent of the recruited subjects developed PE before delivery and 75% remained PE-negative. The serum levels of sFlt-1, BUN, Cre, UA, Cysc and PAPP-A2 were significantly elevated and the PlGF was significantly decreased in the PE-positive patients. The AUCs were listed in the order of decreasing values: UA (AUC = 0.73), sFlt-1/PlGF (AUC = 0.67), Cysc (AUC = 0.66), GlyFn/PlGF (AUC = 0.65), PlGF (AUC = 0.64), PAPP-A2/PlGF (AUC = 0.64), sFlt-1 (AUC = 0.63), BUN (AUC = 0.63), Cre (AUC = 0.63), and PAPP-A2 (AUC = 0.60) in the ROC analyses. The Logistic regression analysis showed that UA and PAPP-A2 were independent risk factors for PE development with the odds ratios of 3.3 and 2.2 respectively. Moreover, the PPVs of UA and PAPP-A2 were 48.9%, and 40.4%; the NPVs of UA and PAPP-A2 were 82.1% and 81.9%.
Conclusions

Further studies are warranted to confirm the clinical utilities of the serum markers in PE prediction.
Trends in Malaria Cases and Stratification of Malaria Incidence in the Malaria Elimination Setting, Harari Region, Eastern Ethiopia
Authors: Esayas Endashaw , Deribe Kebede , Massebo Fekadu , Yared Solomon , Tufa Asefa , Dillu Dereje , Bogale Eyuel Asemahegn 
Published: June 2020

Abstract
Background: Ethiopia has shown a notable progress in reducing the burden of malaria over the last two decades. Based on the progress, the country shifted from control to elimination of malaria. This study was conducted to analyse trends in malaria cases and stratification of malaria incidence in the malaria elimination setting in eastern Ethiopia.Methods: A retrospective malaria data recorded from 2013 to 2019 were reviewed from Harari Region, eastern Ethiopia. In addition, three years malaria data were used to assess the sub-district (kebele) level stratification of malaria incidence.Results: A total of 44,882 (46.9%) malaria cases were detected from 95,629 malaria-suspected outpatient diagnosed in Harari Region from 2013 to 2019. Of these, 41,046 were confirmed malaria cases (microscopically and rapid diagnostic test) while 3,836 were reported as clinical cases. In the region, malaria trend was fluctuating year to year, the high peak was reported in 2016 but malaria cases showed decreasing trend in number of malaria cases from 2017 to 2019. Plasmodium falciparum, P. vivax and mixed infections were accounted for 69.2%, 30.6% and 0.2% of the cases, respectively. The malaria risk appears to be heterogeneous and varies between districts, higher number of malaria cases were recorded in Jenella, Erer and Amir Nur districts, and about 80% of the cases were from these districts. According to the latest (2019) sub-district (kebele) level epidemiological data of malaria stratification, 8.3% of the sub-districts in the Harari region reported no malaria and a majority (61.1%) of sub-districts reported fewer than five cases per thousand population. Furthermore, there were no high malaria strata in the Region. The highest peak of malaria cases in the Region was reported from September to November followed by from April to May.Conclusions: In the Harari Region, the retrospective malaria data showed a significant declining trend. Thus, if this achievement is sustained and scaling-up of the existing malaria prevention and control strategies by focusing on those populations living in the higher malaria transmission districts and sub-districts, planning of malaria elimination from the study area might be feasible.
A retrospective study of noninvasive prenatal testing for chromosome aneuploidies and subchromosomal copy number variations in 24359 single pregnancies
Authors: Liu yuefang , Cheng Longfei , Peng Yuan , Liang Zhe , Jin Xin , Yan Nannan , Pan Qiong 
Published: June 2020

Abstract
Background: With the development of whole-genome sequencing, small subchromosomal deletions and duplications could be found by non-invasive prenatal testing(NIPT). Our study is aimed to review the efficacy of NIPT as a screening test for aneuploidies and subchromosomal copy number variations (CNVs) in 24359 single pregnancies.Methods: A total of 24359 single pregnancies with different clinical features were retrospectively analyzed. Pathogenicity of abnormal NIPT results were assessed according to American College of Medical Genetics and Genomics(ACMG). Chromosome aneuploidies and subchromosomal CNVs were confirmed by karyotyping and chromosomal microarray analysis(CMA). Results: A total of 442 pregnancies (442/24359,1.9%) were with abnormal NIPT results. The positive predictive value (PPV) for trisomy 21(T21), trisomy 18 (T18), trisomy 13 (T13), and sex chromosome aneuploidies (SCAs) was 84.8%, 54.2%, 11.1% an 40.5% respectively. The PPV for subchromosomal CNVs was 59.0% (46/78). The clinical information, prenatal diagnosis results and follow-up results of 46 true positive cases, 6 cases with subchromosomal CNVs inconsistent with NIPT and 1 case of false negative were also demonstrated in detail.Conclusion: Our data have potential significance in demonstrating the significance of NIPT not only for common whole chromosome aneuploidies but also for subchromosomal CNV. Besides, the clinical information, prenatal diagnosis results and follow-up results of 52 cases with subchromosomal CNV and 1 case of false negative would provide important guidance for genetic counseling.
Financial burden reportedly impact quality of life among Lymphatic Filariasis Pathology Patients in Ghana
Authors: Asiedu Samuel Opoku , Amewu Emmanuel Kobla Atsu , Kini Priscilla , Aglomasa Bill Clinton , Forkuor John Boulard , Kwarteng Alexander 
Published: June 2020

Abstract
BackgroundHuman lymphatic filarial pathology is the main cause of disability and poverty among people living with the infection. The second goal of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) is to manage the morbidity associated with the disease with the purpose of improving the quality of life of the patients. Consequently, the current study assessed the overall quality of life of lymphatic filariasis (LF) pathology patients in some selected endemic communities in rural Ghana.MethodIn the present study, the Lymphatic Filariasis Quality of Life Questionnaires (LFSQQ) was used to evaluate the effect of lymphatic filariasis on the quality of life of people with the disease in ten (10) communities in the Ahanta West District of the Western Region of Ghana where, mass drug administration is being implemented for the past twenty years.ResultsOf the 155 study participants recruited, 115 (74.19%) were females and 40 (25.81%) males. A greater proportion of the study participants (40, 25.8%) were presented with stage two (2) lymphedema while only 2 patients had stage seven (7) lymphedema. The average of the overall quality of life scores of study participants was 68.24. There was a negative Pearson correlation (r = -0.504, p-value < 0.0001) between the stage of lymphedema (severity of the disease) and the quality of life of the LF patients. In addition, a clear pattern of positive correlation (r = 0.71, p-value < 0.001) was observed between the disease burden and pain/discomfort domains of the study participants. Whereas, the highest domain specific score (85.03) was observed in the domain of self-care, we noted that the environmental domain, which consist of the financial status was the lowest (45.94) among the study participants.ConclusionOur findings support previous works on the reduced quality of life among lymphatic filariasis patients with pathology. In this study, our results reveal a depressing financial condition among people presenting with late stages of LF pathologies, which eventually reduces their wellbeing.
Akkermansia Muciniphila and Environmental Enrichment Reverse Cognitive Impairment Associated With High-fat High-cholesterol Consumption Through the Gut-brain Axis
Authors: Higarza Sara G. , Arboleya Silvia , Arias Jorge L. , Gueimonde Miguel , Arias Natalia 
Published: June 2020

Abstract
Background: Non-alcoholic steatohepatitis (NASH) is one of the most prevalent diseases worldwide. A high-fat, high-cholesterol (HFHC) diet leads to an early NASH model. It has been suggested that gut microbiota mediates the effects of diet through the microbiota-gut-brain axis, modifying the host’s brain metabolism and disrupting cognition.Results: Here, we target NASH-induced cognitive damage by testing the impact of environmental enrichment (EE) and the administration of either Lacticaseibacillus rhamnosus GG (LGG) or Akkermansia muciniphila CIP107961 (AKK). EE and AKK, but not LGG, reverse the HFHC-induced cognitive dysfunction, including impaired spatial working memory and novel object recognition; however, whereas AKK restores brain metabolism, EE produces an overall decrease. Moreover, AKK and LGG did not induce major rearrangements in the intestinal microbiota, with only slight changes in bacterial composition and diversity, whereas EE entailed an increase in Firmicutes and Verrucomicrobia members.Conclusions: Our findings illustrate the interplay between gut microbiota, the host’s brain energy metabolism, and cognition, and they suggest intervention strategies, such as the administration of AKK, for the management of the cognitive dysfunction related to NASH.
COVID 19 Pandemic: A Real-time Forecasts &amp; Prediction of Confirmed Cases, Active Cases using the ARIMA model &amp;Public Health in West Bengal, India.
Authors: Sarkar Dibash 
Published: June 2020

Abstract
Background: COVID-19 is an emerging infectious disease which has been declared a Pandemic by the World Health Organization (WHO) on March 11 2020. This pandemic has spread over the world in more than 200 countries. India is also adversely affected by this pandemic, and there are no signs of slowing down of the virus in coming time. The absence of a vaccine for COVID-19 is making the situation worse for the already overstretched Indian public health care system. As economic burden makes it increasingly difficult for our country to continue imposing control measures, it is vital for states like West Bengal to make predictions using time series forecasting for the upcoming cases , test kits , health care and estimated the requirement of Quarantine centers, isolation beds, ICU beds and ventilators for COVID-19 patients .Objective: This study is forecasting the confirmed and active cases for COVID-19 until August, using time series ARIMA model & Public Health in West Bengal, India.Methods: We used ARIMA model, and Auto ARIMA model for forecasting confirmed and active cases till the end of August month using time series data of COVID-19 cases in West Bengal, India from March 1, 2020, to June 4, 2020.Discussion and Conclusion: This forecasts show a very crucial situation for West Bengal in coming days and, the actual numbers can go higher than our estimates of confirmed case as Lockdown 5.0 & Unlock 1.0 will be implemented from 1st June 2020 in India, West Bengal will be observing a partial lift of the lockdown and in that case, there will be a surge in the number of daily confirmed and active cases. The requirement of Health care sector needs to be further improved isolation beds, ICUs and ventilators will also be needed to increase in that scenario. Inter State & Intra State Movement restrictions are lifted. Hence, Migrants returning to their homes due to loss of livelihood and income in the lockdown period may lead to a rise in the number of cases, which could not be accounted for in our projections. We suggest more of Public-Private Partnership (PPP) model in the health sector to accommodate COVID-19 patients adequately and reduce the burden of the already overstretched Indian public health care system, which will directly or indirectly affect the States in the time of crisis.
Pharmacists’ perceived barriers towards delivering their emergency roles during the COVID-19 pandemic and perceived policymakers’ responsibilities&nbsp;
Authors: Basheti Iman , Nassar Razan , Barakat Muna , Alqudah Rajaa , Farha Rana Abu , Muqatash Tareq , Thiab Samar , Saini Bandana 
Published: June 2020

Abstract
Rational: In March 2020, the World Health Organization (WHO) declared the coronavirus infectious disease as a pandemic referred to as COVID-19. As an essential service, community pharmacists have been enacting a key role in patient counseling and supply of essential medicines and protective equipment. Objectives: To investigate pharmacists’ perspectives of the role of educational institutes and professional pharmacy organizations in supporting them to take on roles during COVID-19 pandemic and to identify barriers to be able to support themselves and their patients. Methods: This descriptive mixed-method study was conducted via a cross-sectional online survey distributed to pharmacists/pharmacy students in Jordan during the COVID-19 outbreak (15-30 March 2020) using an online questionnaire, followed by an online focus group. Questionnaire items related to participants’ perspectives in being prepared for and supported in their roles during the COVID-19 pandemic and items were tested for face validity. Data were descriptively analyzed using the Statistical Package for the Social Sciences and triangulated with focus group findings.Results: Considering that fear and anxiety are a consequence of mass social distancing/quarantine, study participants (n=726, age=26.9 (SD=8.0) years, 71.9% females), reported needing training on mental healthcare to be able to support themselves and people during pandemics (90.2%). Most respondents agreed/strongly agreed (59.7%) with the statement around pharmacy educators/educational institutes having a key role in preparing pharmacists for practice during epidemics/pandemics, and agreed that their faculties should add a course regarding pandemic preparedness in their curriculum (89.9%). Results were similar regarding roles for the pharmaceutical associations. Focus group findings (n=7) mirrored the survey findings to a large extent.Conclusions: Most participants believed that Pharmacy Educators and pharmaceutical associations have a role in preparing them to deal with the COVID-19 pandemic through online educational workshops/webinars. Online education on mental healthcare is specifically needed.
A through process modeling using multi-assistant software applied to radial fatigue life predication of a 356-T6 wheels
Authors: Duan Yongchuan , Zhang Fangfang , Tian Le , Guan Yingping , Hu Jinhua 
Published: June 2020

Abstract
In order to solve the problem of isolated design in multi-process using multi-assistant software, a through-software radial fatigue life prediction model was established, the effects of shrinkage cavity, SDAS and mean stress on fatigue life were considered. The casting process of the aluminum alloy wheel was simulated based on ProCast, and the data of SDAS and porosity of different parts were predicted based on the solidification process; The data mapping algorithm between tetrahedral mesh elements was developed to realize the unidirectional transformation of microcosmic data from a cast model to a static mechanical model, the radial loading mechanical analysis model of a wheel containing microcosmic information was established; The fatigue life prediction model was established by Fesafe based on the specific mechanical and fatigue parameters of each node. Based on the self-developed TCD software, the integrated coupling method of the three software prediction models was realized. The application of this method on the virtual fatigue prediction experiment of unidirectional tensile specimen reduce the result dispersion between virtual and physical experiment, and the predicted life result error is reduced from 51% to 16%. The proposed method lays a solid foundation of the optimization design and lightweight design of aluminum alloy wheels.
Identifying pathways and networks associated with the SARS-CoV-2 cell receptor ACE2 based on gene expression profiles in human tissues
Authors: Feng Qiushi , Li Lin , Wang Xiaosheng 
Published: June 2020

Abstract
The angiotensin-converting enzyme 2 (ACE2) is a host cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has infected more than six million people worldwide and has caused more than 370,000 deaths as of May 31, 2020. An investigation of ACE2 expression in human tissues may provide insights into the mechanism of SARS-CoV-2 infection. We identified pathways associated with ACE2 expression and gene co-expression networks of ACE2 in pan-tissue based on the gene expression profiles in human tissues. We found that the pathways significantly associated with ACE2 upregulation were mainly involved in immune, stromal signature, metabolism, cell growth and proliferation, and cancer and other diseases. The number of genes having a significant positive expression correlation with ACE2 in females far exceeded that in males. The estrogen receptors (ESR1 and ESR2) and androgen receptor (AR) genes had a significant positive expression correlation with ACE2 in pan-tissue. Meanwhile, the enrichment levels of immune cells were positively associated with the expression levels of ESR1 and ESR2, while they were inversely associated with the expression levels of AR in pan-tissue and in multiple individual tissues. It suggests that females are likely to have a more robust immune defense system against SARS-CoV-2 than males, partially explaining why females have better clinical outcomes of SARS-CoV-2 infections than males. Our data warrant further investigation for understanding the mechanism of SARS-CoV-2 infection.
Summary of the COVID-19 epidemic in China: When and how to launch an emergency response
Authors: Tao Junwen , Ma Yue , Luo Caiying , Huang Jiaqi , Zhang Tao , Yin Fei 
Published: June 2020

Abstract
In December 2019, Coronavirus Disease 2019 (COVID-19) was first detected in Hubei Province and spread rapidly around the world. Summarizing the development of COVID-19 and assessing the effect of control measures are very critical to China and other countries. A heatmap was used to find the highest concentration of the COVID-19 outbreak and the areas with initial imported cases. A logistic growth curve model was employed to compare the development of COVID-19 before and after the emergency response took effect. We found that the number of confirmed cases peaked 9-14 days after the first detection of an imported case, but there was a peak lag in the province where the outbreak was concentrated. The average growth rate of cumulative confirmed cases decreased by approximately 50% after the emergency response began. Areas with frequent population migration have a high risk of outbreak. The emergency response taken by the Chinese government was able to effectively control the COVID-19 outbreak. Our study provides references for other countries and regions to control the COVID-19 outbreak.
COMPARAÇÃO DOS CUSTOS DO SETOR DE NUTRIÇÃO E DIETÉTICA DE UM HOSPITAL PÚBLICO E DE UM PRIVADO
Authors: Abbas Katia , Negrelli da Silva Beatriz , Leoncine Maury 
Published: June 2020

Objetivo: Este estudo tem como objetivo comparar os custos do setor de nutrição e dietética de um hospital público e de um privado e analisar a viabilidade de oferecer ou terceirizar o serviço.
Método: Para o cálculo do custo das refeições (café da manhã, almoço, café da tarde e jantar) foi utilizado o método do custeio por absorção, que considera os custos diretos (mão de obra das cozinheiras, auxiliares de cozinha e copeiras); e os custos indiretos de produção (serviços de manutenção, água, energia elétrica, telefone, depreciação dos equipamentos, e gás).
Fundamentação teórica: Foi abordada a gestão de custos em hospitais, ressaltando a importância da apuração e o controle de custos para tomada de decisão, bem como a terceirização de custos em hospitais.
Resultados: Os resultados evidenciam que o valor obtido para café da manhã e da tarde, tanto para o hospital público quanto para o privado, respectivamente, foram de R$2,99 e R$15,59. Para almoço e jantar, com carne bovina, foram de R$15,69 e R$21,72; com carne de frango R$13,89 e R$21,32; e dieta leve R$10,45 e R$19,55.
Conclusões/contribuições: Desse modo, observa-se que o hospital privado tem maior custo em relação ao público, devido, principalmente, à diferença dos itens dos cardápios. Foram comparados os valores encontrados com o de empresas terceirizadas constatando-se a inviabilidade tanto para o hospital público quanto para o privado terceirizar o serviço.
A clinical case of using ICG-technologies to evaluate the results of the superior mesenteric artery stenting in a patient with acute mesenteric ischemia
Authors: Khitaryan A. G. , Murlychev A. S. , Bondarenko I. V. , Kovalev S. A. , Veliev K. S. , Orekhov A. A. , Alibekov A. Z. , Mezhunts A. V. , Golovina A. A. 
Published: June 2020

Introduction. Acute mesenteric ischemia is a rare, but extremely severe life-threatening condition with a mortality rate of 40 to 60%, despite the development of modern high-tech diagnostic and treatment methods. Unfortunately, acute mesenteric ischemia does not have any pathognomonic symptoms or highly specific laboratory and instrumental symptoms and manifests as abdominal pain syndrome, which makes it harder to differentiate diagnosis and results in a delay in taking appropriate therapeutic measures.Clinical case. This clinical case report describes a case of a 70-year-old patient who was admitted to the cardiology department after undergoing percutaneous coronary intervention due to acute myocardial infarction. On the third day, the patient developed severe diffuse abdominal pain and diarrhea. After the series of diagnostic measures have been performed, an acute impairment of mesenteric circulation was suspected and a decision was made to perform spiral computed tomography, which confirmed the presence of a thrombus in the superior mesenteric artery. The patient underwent X-ray endovascular thrombospiration, transluminal balloon angioplasty and stenting of the superior mesenteric artery. Due to the persistence of abdominal pain on the following day, the patient also underwent a diagnostic laparoscopy using ICG technologies to assess the presence and severity of ischemic and necrotic intestinal changes. After six months from the date of discharge, the patient continues to be followed-up by a cardiologist.Conclusions. The timely performance of spiral computed tomography in patients with suspected acute mesenteric ischemia in the vascular regimen, angiography, endovascular interventions to restore blood supply to the intestine and ICG control of perfusion is appropriate to improve the treatment outcomes of this category of patients.