bluuebunny/crossref_metadata_2025_split huggingface dataset:
تحليل النتاج الفكري لمصطلح إنترنت الأشياء في قاعدة بياناتScopus للفترة (2010–2018)
Authors: السلامية أسماء بنت علي , المعمرية ماريا بنت عبدالله 
Published: April 2020

ملخص

منذ بداية ظهور الإنترنت وثورة الاتصالات أصبحت المعلومات في تغير جذري؛ إذ أحدث قفزة كبيرة في عالم الإنترنت، وأصبح التوجه من إنترنت الاتصالات إلى إنترنت الأشياء، مما سهل عملية توصيل الأشياء ونقل البيانات، وتأتي هذه الدراسة لبيان مفهوم إنترنت الأشياء ودراسة طبيعة تأثيرها في المكتبات الأكاديمية، ثم تحليل حجم النتاج الفكري حول هذا الموضوع في قاعدة بيانات Scopus خلال السنوات (2010–2018)، وقد أظهرت النتائج وجود 47,302 دراسة، وأن أغلب الدراسات كانت في عام 2018؛ ويعزى ذلك لاتضاح معالم المصطلح بمرور السنوات لكونه مصطلح جديد إلى حدٍ ما، وتعد الصين عامةً وجامعة بكين للبريد والاتصالات خاصةً الأكثر اهتمامًا بالنشر في هذا المجال؛ ويرجع ذلك لكون الصين من الدول الصناعية الكبيرة، وان إنترنت الأشياء واحدة من هذه الصناعات، كما أظهرت النتائج أن أعمال المؤتمرات هي أكثر أنواع مصادر المعلومات التي نشرت في انترنت الأشياء تليها المقالات العلمية، وقد حظي تخصص علوم الحاسب الآلي أكثر المجالات الموضوعية تداولاً.
في حين أن النتاج الفكري لجامعة السلطان قابوس حول إنترنت الأشياء بلغ 36 دراسة، وأن أعمال المؤتمرات حظيت بالنسبة الأكبر؛ وقد يعود ذلك لعدم وجود معايير صارمة عند نشر أوراق عمل في المؤتمرات بخلاف ما هو موجود عند النشر في المجلات العلمية، والتي قد تختلف من مجلة إلى أخرى، وأن مصطلح إنترنت الأشياء ورد في 12 تخصص موضوعي، أغلبها كانت لعلوم الحاسب الآلي، وأقلها في العلوم الاجتماعية؛ ويرجع السبب في وجود عدد كبير من الدراسات قد تكون نشرت باللغة العربية وهي غير مكشفة في SCOPUS.
Cyclic voltammetry: a simple method for determining contents of total and free iron ions in sodium ferric gluconate complex
Authors: Liu Hong , Yu Qiao , Ma Yixuan , Liu Baoyu , Pan Hongchun 
Published: April 2020

<p class="PaperAbstract">Sodium ferric gluconate complex (SFGC) is the third generation of iron supplement of polysaccharide iron (III) complex (PIC). For evaluation of technological level and application value of the prepared SFGC, it would be of great significance to determine the iron content in SFGC in a simple but effective way. This paper introduces the cyclic voltammetry (CV) method for determination of iron content in SFGC. Under established optimal experimental conditions, the content of free iron ions can be directly scanned and calculated, while the total iron content can also be determined by completely acidifying SFGC into Fe<sup>3+</sup> ions. After optimizing and screening, the optimal scanning conditions are determined as pH 3 and 0.05 V/s of the scanning rate. Prior CV measurements, 0.4 V of the enrichment potential, and 3 min of the enrichment time are found optimal. It has also been verified that CO<sub>3</sub><sup>2-</sup> ions present in the solution show little interference in the system within the experimental range of investigation. The contents of free Fe<sup>3+</sup>, Fe<sup>2+</sup> ions and the total iron determined after acid-hydrolysis of SFGC can be accurately calculated according to the corresponding linear relationships between peak currents and iron concentrations. In this paper, the repeatability and accuracy of the method are verified, and its feasibility as a convenient and effective method to determine the iron supplements is confirmed.</p>
A Rechargeable Zn–Air Battery with High Energy Efficiency and Long Life Enabled by a Highly Water‐Retentive Gel Electrolyte with Reaction Modifier
Authors: Song Zhishuang , Ding Jia , Liu Bin , Liu Xiaorui , Han Xiaopeng , Deng Yida , Hu Wenbin , Zhong Cheng 
Published: April 2020

AbstractTremendous effort have recently been made in optimizing the air catalysts of flexible zinc–air batteries (ZABs). Unfortunately, the bottleneck factors in electrolytes that largely limit the working life and energy efficiency of ZABs have long been relatively neglected. Herein, an alkaline gel polymer electrolyte (GPE) is fabricated through multiple crosslinking reactions among poly(vinyl alcohol) (PVA), poly(acrylic acid), and graphene oxide followed by intense uptake of an alkali and the KI reaction modifier. The prepared GPE exhibits essentially improved properties compared to traditional PVA gel electrolyte in terms of mechanical strength, ionic conductivity, and water retention capability. In addition, the introduced reaction modifier I− in the GPE changes the path of the conventional oxygen evolution reaction, leading to a more thermodynamically favorable path. The optimized GPE enables flexible ZABs exhibiting an exceptionally low charge potential of 1.69 V, a long cycling time of 200 h, a high energy efficiency of 73%, and rugged reliability under different extreme working conditions. Moreover, the successful integration of ZABs in a variety of real wearable electronic devices demonstrates their excellent practicability as flexible power sources.
Gomez–López–Hernández syndrome: A case report with clinical and molecular evaluation and literature review
Authors: Perrone Eduardo , D'Almeida Vânia , de Macena Sobreira Nara Lygia , de Mello Claudia Berlim , de Oliveira Allan Chiaratti , Burlin Stênio , Soares Maria de Fátima de Faria , Cernach Mirlene Cecília Soares Pinho , Alvarez Perez Ana Beatriz 
Published: April 2020

AbstractGomez–López–Hernández syndrome (GLHS) is characterized by rhombencephalosynapsis (RES), alopecia, trigeminal anesthesia and a distinctive phenotype, including brachyturricephaly. It has been suggested that GLHS should be considered as part of the spectrum of RES‐associated conditions that include alopecia, trigeminal anesthesia, and craniofacial anomalies, rather than a distinct entity. To the best of our knowledge, 57 patients with GLHS have been described. Despite its first description in 1979, the etiology of this syndrome remains unknown. Here, we describe, to our knowledge, the first case of a patient with GLHS who was molecularly evaluated and had been prenatally exposed to misoprostol. We also reviewed the clinical and morphological features of the patients described to date to better delineate the phenotype and focus on any evidence for adverse pregnancy outcomes or exposure, including teratogens.
CDH1‐related blepharocheilodontic syndrome is associated with diffuse gastric cancer risk
Authors: LeBlanc Shannon , Naveen Dildeepa , Haan Eric , Barnett Christopher , Rawlings Lesley , Roscioli Tony , Poplawski Nicola 
Published: April 2020

AbstractWe report the first case of diffuse gastric cancer in an individual with familial blepharocheilodontic syndrome (BCD) due to a germline CDH1 likely pathogenic variant. To date, other BCD affected relatives are nonpenetrant for diffuse gastric cancer posing challenges to counseling regarding gastric and breast cancer surveillance, and preventative total gastrectomy.
Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues
Authors: Muraoka Satoshi , DeLeo Annina M. , Sethi Manveen K. , Yukawa‐Takamatsu Kayo , Yang Zijian , Ko Jina , Hogan John D. , Ruan Zhi , You Yang , Wang Yuzhi , Medalla Maria , Ikezu Seiko , Chen Mei , Xia Weiming , Gorantla Santhi , Gendelman Howard E. , Issadore David , Zaia Joseph , Ikezu Tsuneya 
Published: April 2020

AbstractIntroductionExtracellular vesicles (EVs) from human Alzheimer's disease (AD) biospecimens contain amyloid beta (Aβ) peptide and tau. While AD EVs are known to affect brain disease pathobiology, their biochemical and molecular characterizations remain ill defined.MethodsEVs were isolated from the cortical gray matter of 20 AD and 18 control brains. Tau and Aβ levels were measured by immunoassay. Differentially expressed EV proteins were assessed by quantitative proteomics and machine learning.ResultsLevels of pS396 tau and Aβ1–42 were significantly elevated in AD EVs. High levels of neuron‐ and glia‐specific factors are detected in control and AD EVs, respectively. Machine learning identified ANXA5, VGF, GPM6A, and ACTZ in AD EV compared to controls. They distinguished AD EVs from controls in the test sets with 88% accuracy.DiscussionIn addition to Aβ and tau, ANXA5, VGF, GPM6A, and ACTZ are new signature proteins in AD EVs.
Die Länge einer Ubiquitinkette: ein genereller Faktor für die selektive Erkennung durch Ubiquitin‐bindende Proteine
Authors: Lutz Joachim , Höllmüller Eva , Scheffner Martin , Marx Andreas , Stengel Florian 
Published: April 2020

AbstractDie Anheftung von Ubiquitin (Ub)‐Ketten variierender Länge an Substratproteine ist eine häufige posttranslationale Modifikation. Das Schicksal eines modifizierten Proteins ist abhängig von Ubiquitin‐bindenden Proteinen (UBPs), die mit Ub‐Ketten in Abhängigkeit vom Verknüpfungstyp interagieren. Der Einfluss der Kettenlänge auf die Selektivität von UBPs und die entsprechenden funktionellen Konsequenzen sind weitgehend unbekannt. Wir haben Ketten mit definierter Länge und Verknüpfungsart hergestellt, indem wir Klick‐Chemie mit GELFrEE‐Fraktionierung kombiniert haben. Diese definierten Ketten nutzten wir in affinitätsbasierten Anreicherungsassays, um längen‐ und verknüpfungsspezifische Interaktoren auf Proteomebene zu identifizieren. Erstmals konnte nachgewiesen werden, dass die Länge einer Ub‐Kette einen erheblichen Einfluss auf ihre Fähigkeit hat, von UBPs selektiv erkannt zu werden.
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
Authors: Smedley Christopher J. , Li Gencheng , Barrow Andrew S. , Gialelis Timothy L. , Giel Marie‐Claire , Ottonello Alessandra , Cheng Yunfei , Kitamura Seiya , Wolan Dennis W. , Sharpless K. Barry , Moses John E. 
Published: April 2020

AbstractDiversity Oriented Clicking (DOC) is a unified click‐approach for the modular synthesis of lead‐like structures through application of the wide family of click transformations. DOC evolved from the concept of achieving“diversity with ease”, by combining classic C−C π‐bond click chemistry with recent developments in connective SuFEx‐technologies. We showcase 2‐Substituted‐Alkynyl‐1‐SulfonylFluorides (SASFs) as a new class of connective hub in concert with a diverse selection of click‐cycloaddition processes. Through the selective DOC of SASFs with a range of dipoles and cyclic dienes, we report a diverse click‐library of 173 unique functional molecules in minimal synthetic steps. The SuFExable library comprises 10 discrete heterocyclic core structures derived from 1,3‐ and 1,5‐dipoles; while reaction with cyclic dienes yields several three‐dimensional bicyclic Diels–Alder adducts. Growing the library to 278 discrete compounds through late‐stage modification was made possible through SuFEx click derivatization of the pendant sulfonyl fluoride group in 96 well‐plates—demonstrating the versatility of the DOC approach for the rapid synthesis of diverse functional structures. Screening for function against MRSA (USA300) revealed several lead hits with improved activity over methicillin.
DNA–Polymer Nanostructures by RAFT Polymerization and Polymerization‐Induced Self‐Assembly
Authors: Lückerath Thorsten , Koynov Kaloian , Loescher Sebastian , Whitfield Colette J. , Nuhn Lutz , Walther Andreas , Barner‐Kowollik Christopher , Ng David Y. W. , Weil Tanja 
Published: April 2020

AbstractNanostructures derived from amphiphilic DNA–polymer conjugates have emerged prominently due to their rich self‐assembly behavior; however, their synthesis is traditionally challenging. Here, we report a novel platform technology towards DNA–polymer nanostructures of various shapes by leveraging polymerization‐induced self‐assembly (PISA) for polymerization from single‐stranded DNA (ssDNA). A “grafting from” protocol for thermal RAFT polymerization from ssDNA under ambient conditions was developed and utilized for the synthesis of functional DNA–polymer conjugates and DNA–diblock conjugates derived from acrylates and acrylamides. Using this method, PISA was applied to manufacture isotropic and anisotropic DNA–polymer nanostructures by varying the chain length of the polymer block. The resulting nanostructures were further functionalized by hybridization with a dye‐labelled complementary ssDNA, thus establishing PISA as a powerful route towards intrinsically functional DNA–polymer nanostructures.
The Length of a Ubiquitin Chain: A General Factor for Selective Recognition by Ubiquitin‐Binding Proteins
Authors: Lutz Joachim , Höllmüller Eva , Scheffner Martin , Marx Andreas , Stengel Florian 
Published: April 2020

AbstractThe attachment of ubiquitin (Ub) chains of various length to proteins is a prevalent posttranslational modification in eukaryotes. The fate of a modified protein is determined by Ub‐binding proteins (UBPs), which interact with Ub chains in a linkage‐selective manner. However, the impact and functional consequences of chain length on the binding selectivity of UBPs remain mostly elusive. We have generated Ub chains of defined length and linkage by using click chemistry and GELFrEE fractionation. These defined polymers were used in affinity‐based enrichment assays to identify length‐ and linkage‐selective interaction partners on a proteome‐wide scale. For the first time, it is revealed that the length of a Ub chain generally has a major impact on its ability to be selectively recognized by UBPs.
Catechol‐bearing imidazolium and benzimidazolium chlorides as promising antimicrobial agents
Authors: Karataş Mert O. , Günal Selami , Mansur Ahmet , Alıcı Bülent , Özdemir İsmail 
Published: April 2020

AbstractCatechol‐containing imidazolium (four) and benzimidazolium chlorides (eight) were synthesized to evaluate their antimicrobial properties. All the compounds were fully characterized using 1H and 13C nuclear magnetic resonance, liquid chromatography–mass spectrometry, infrared spectroscopic methods, and elemental analyses. Antimicrobial activities of the compounds were tested against the bacteria Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus, methicillin‐resistant S. aureus (MRSA), Enterococcus faecalis, and the fungal strains Candida albicans and Candida glabrata, and promising results were achieved. The two most important benzyl‐substituted benzimidazolium chlorides, 3l and 3k, showed comparable activity to vancomycin against MRSA.
Eustress and Distress: Neither Good Nor Bad, but Rather the Same?
Authors: Bienertova‐Vasku Julie , Lenart Peter , Scheringer Martin 
Published: April 2020

AbstractThe terms “eustress” and “distress” are widely used throughout the scientific literature. As of February 2020, 203 items in the Web of Science show up in a search for “eustress,” however, there are almost 16 400 items found in a search for the term “distress.” Based on the reasoning in this article, however, it is believed there is no such thing as eustress or distress. The adaptation reaction of an organism under stress is not intrinsically good or bad, and its effect on health or performance depends on a plethora of other interactions of the body with the environment as well as on the history of such interactions. The vagueness of the terms “eustress/distress” has historically led to vast differences in the perception and application of the terms across disciplines. While psychology or sociology perceive eustress as something inextricably linked to positive perception and enhanced cognition, biomedicine perceives eustress as generally associated with better survival, health, or increased longevity, no matter how the event is perceived. In this paper, the authors review the current understanding of the term “eustress” in different fields, discuss possible implications of its misleading use, and suggest that the term may be replaced by “stress” only.
Validation of a simplified procedure for convenient and rapid quantification of reduced and oxidized glutathione in human plasma by liquid chromatography tandem mass spectrometry analysis
Authors: Enomoto Addison C. , Schneider Erik , McKinnon Toni , Goldfine Howard , Levy Mark A. 
Published: April 2020

AbstractEndogenous glutathione (GSH) and glutathione disulfide (GSSG) status is highly sensitive to oxidative conditions and have broad application as a surrogate indicator of redox status in vivo. Established methods for GSH and GSSG quantification in whole blood display limited utility in human plasma, where GSH and GSSG levels are ~3–4 orders of magnitude below those observed in whole blood. This study presents simplified sample processing and analytical LC–MS/MS approaches exhibiting the sensitivity and accuracy required to measure GSH and GSSG concentrations in human plasma samples, which after 5‐fold dilution to suppress matrix interferences range from 200 to 500 nm (GSH) and 5–30 nm (GSSG). The utility of the methods reported herein is demonstrated by assay performance and validation parameters which indicate good sensitivity [lower limits of quantitation of 4.99 nm (GSH) and 3.65 nm (GSSG), and high assay precision (intra‐assay CVs 3.6 and 1.9%, and inter‐assay CVs of 7.0 and 2.8% for GSH and GSSG, respectively). These methods also exhibited exceptional recovery of analyte‐spiked plasma samples (98.0 ± 7.64% for GSH and 98.5 ± 12.7% for GSSG). Good sample stability at −80°C was evident for GSH for up to 55 weeks and GSSG for up to 46 weeks, with average CVs <15 and <10%, respectively.
Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy
Authors: Tan Wei Chang Colin , Nerurkar Sanjna Nilesh , Cai Hai Yun , Ng Harry Ho Man , Wu Duoduo , Wee Yu Ting Felicia , Lim Jeffrey Chun Tatt , Yeong Joe , Lim Tony Kiat Hon 
Published: April 2020

AbstractConventional immunohistochemistry (IHC) is a widely used diagnostic technique in tissue pathology. However, this technique is associated with a number of limitations, including high inter‐observer variability and the capacity to label only one marker per tissue section. This review details various highly multiplexed techniques that have emerged to circumvent these constraints, allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition, cellular functional and cell‐cell interactions. Among these techniques, multiplex Immunohistochemistry/Immunofluorescence (mIHC/IF) has emerged to be particularly promising. mIHC/IF provides high‐throughput multiplex staining and standardized quantitative analysis for highly reproducible, efficient and cost‐effective tissue studies. This technique has immediate potential for translational research and clinical practice, particularly in the era of cancer immunotherapy.
A computer‐aided educational tool for vector control of AC motors in graduate courses
Authors: Aktaş Mustafa , Çavuş Barış 
Published: April 2020

AbstractAnalysis of dynamic behavior of alternating current (AC) motors and their vector control has an important place in the education of electrical and electronics engineering at the graduate level. Generally, only theoretical education in engineering affects motivation of both educators and students negatively. Particularly, in graduate education, realization of subjects of AC motors in laboratory facility enables students to learn effectively. However, it may not be easy to implement because of establishing cost of a physical laboratory environment in universities. Therefore, by using visual software technology, engineering applications such as vector control of AC motors can be prepared in a simulation tool and students' active learning skills can be developed without any cost by means of visual simulation studies. Hence, in this study, an educational interface was prepared as a simulation for vector control of AC motors by using MATLAB GUI. In this application, two types of AC motors (induction motor and permanent magnet synchronous motor) and two types of vector control (direct torque control and field‐oriented control) can be realized. In the simulation, after selecting motor and vector control type, determination of speed acquisition method and speed control method can be selected, and simulation study can be performed easily. Performance of selected motor type and control methods can be evaluated by using current, speed, torque, and energy consumed. In addition, to see success of the developed tool, it was used by the students at Ondokuz Mayis University, and at the end of lesson, a questionnaire was made and students' ideas were taken.
Predictive role of Selvester QRS score in patients undergoing transcatheter aortic valve replacement
Authors: Bignoto Tiago Costa , Le Bihan David , de Mattos Barretto Rodrigo Bellio , de Oliveira Ramos Auristela Isabel , Moreira Dalmo Antônio Ribeiro , Simonato Matheus , de Alvim Siqueira Dimytri Alexandre , Pinto Ibraim Masciarelli Francisco , dos Santos Tiago Senra Garcia , de Moraes Rego Sousa Amanda Guerra , Abizaid Alexandre 
Published: April 2020

AbstractIntroductionFew data exist regarding the late clinical impact of the Selvester score prediction of myocardial fibrosis after transcatheter aortic valve replacement (TAVR). This study evaluated the predictive power of the Selvester score on survival in patients with aortic stenosis (AS) undergoing TAVR.methods and resultsPatients with severe AS who had preoperative electrocardiograms were included. Clinical follow‐up was obtained retrospectively. The primary endpoint was all‐cause mortality. Secondary endpoints were cardiovascular death and major adverse cardiac events (MACEs). Two‐hundred twenty‐eight patients were included (mean age, 81.5 ± 7.4 years; women, 58.3%). Deceased patients had a higher mean score (4.6 ± 3.2 vs. 1.4 ± 1.3; p < .001). At a mean follow‐up of 36.2 ± 21.2 months, the Selvester score was independently associated with all‐cause mortality (hazard ratio [HR], 1.65; 95% confidence interval [CI], 1.48–1.84; p < .001), cardiovascular death (HR, 1.59; 95% CI, 1.38–1.74; p < .001), and MACE (HR, 1.55; 95% CI, 1.30–1.68; p < .001). After 5 years, the mortality risk was incrementally related to the Selvester score. The involvement of the inferior wall of the left ventricle was a lower mortality risk factor (HR, 0.42; 95% CI, 0.18–0.98; p = .046). For a Selvester score of 3, the area under the curve showed 0.92, 0.94, and 0.86 (p < .001), respectively, for 1, 2, and 3 years.conclusionsElevated Selvester scores increase the risk of poor outcomes in patients with AS undergoing TAVR. The involvement of the anterior or lateral wall presents worse prognosis.
High‐molecular‐weight glutenin subunit compositions in current Chinese commercial wheat cultivars and the implication on Chinese wheat breeding for quality
Authors: Gao Song , Sun Genlou , Liu Weihua , Sun Daokun , Peng Yanchun , Ren Xifeng 
Published: April 2020

AbstractBackground and objectivesGenetic diversity of high‐molecular‐weight (HMW) glutenin subunits is often used for wheat improvement because of its correlation with end‐use quality of wheat. The objectives were (a) to characterize and analyze the HMW‐GS composition of common wheat, (b) determine the diversity of high‐molecular‐weight glutenin subunits, and (c) elucidate the distribution characteristics of wheat good‐quality subunit and quality classification.FindingsThe results revealed a total of 15 different alleles (3 at Glu‐A1, 8 at Glu‐B1, and 4 at Glu‐D1) and 35 allele combinations. Glu‐A1c (57.92%), Glu‐A1a (62.94%), Glu‐A1c (55.86%) appeared to be the most frequent alleles at Glu‐A1 in Hebei, Henan, and Sichuan provinces, respectively. The Glu‐B1c was the most common allele at the Glu‐B1 locus in all three provinces, with frequencies of 48.75%, 55.24%, and 29.66%, respectively. Glu‐D1a (66.25%), Glu‐D1d (53.85%), Glu‐D1a (55.17%) at the Glu‐D1 locus appeared to be the common alleles in Hebei, Henan, and Sichuan provinces, respectively. Cluster analysis based on allelic similarity of Glu‐1 loci classified the 528 wheat cultivars into two major categories.ConclusionsThese results indicated that the HMW glutenin allele compositions are not optimal for the current varieties in these provinces. A high level of quality improvement may be implemented by increasing the frequencies of Glu‐A1a (1) or Glu‐A1b (2*), Glu‐B1i (17 + 18), Glu‐D1d (5 + 10).Significance and noveltyOur results revealed clear directions for wheat quality improvement in these provinces.