bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonparametric Anomaly Detection on Time Series of Graphs
Authors: Ofori-Boateng Dorcas , Gel Yulia R. , Cribben Ivor 
Published: December 2019

AbstractIdentifying change points and/or anomalies in dynamic network structures has become increasingly popular across various domains, from neuroscience to telecommunication to finance. One of the particular objectives of the anomaly detection task from the neuroscience perspective is the reconstruction of the dynamic manner of brain region interactions. However, most statistical methods for detecting anomalies have the following unrealistic limitation for brain studies and beyond: that is, network snapshots at different time points are assumed to be independent. To circumvent this limitation, we propose a distribution-free framework for anomaly detection in dynamic networks. First, we present each network snapshot of the data as a linear object and find its respective univariate characterization via local and global network topological summaries. Second, we adopt a change point detection method for (weakly) dependent time series based on efficient scores, and enhance the finite sample properties of change point method by approximating the asymptotic distribution of the test statistic using the sieve bootstrap. We apply our method to simulated and to real data, particularly, two functional magnetic resonance imaging (fMRI) data sets and the Enron communication graph. We find that our new method delivers impressively accurate and realistic results in terms of identifying locations of true change points compared to the results reported by competing approaches. The new method promises to offer a deeper insight into the large-scale characterizations and functional dynamics of the brain and, more generally, into intrinsic structure of complex dynamic networks.
A Multi-Niche Microvascularized Human Bone-Marrow-on-a-Chip
Authors: Nelson Michael R. , Ghoshal Delta , Mejías Joscelyn C. , Frey Rubio David , Keith Emily , Roy Krishnendu 
Published: December 2019

AbstractThe human bone marrow (hBM) is a complex organ critical for hematopoietic and immune homeostasis, and where many cancers metastasize. Yet, understanding the fundamental biology of the hBM in health and diseases remain difficult due to complexity of studying or manipulating the BM in humans. Accuratein vitromodels of the hBM microenvironment are critical to further our understanding of the BM niche and advancing new clinical interventions. Although,in vitroculture models that recapitulate some key components of the BM niche have been reported, there are no examples of a fully human,in vitro, organoid platform that incorporates the various niches of the hBM - specifically the endosteal, central marrow, and perivascular niches – thus limiting their physiological relevance. Here we report an hBM-on-a-chip that incorporates these three niches in a single micro-physiological device. Osteogenic differentiation of hMSCs produced robust mineralization on the PDMS surface (“bone layer”) and subsequent seeding of endothelial cells and hMSCs in a hydrogel network (“central marrow”) created an interconnected vascular network (“perivascular niche”) on top. We show that this multi-niche hBM accurately mimics the ECM composition, allows hematopoietic progenitor cell proliferation and migration, and is affected by radiation. A key finding is that the endosteal niche significantly contributes to hBM physiology. Taken together, this multi-niche micro-physiological system opens up new opportunities in hBM research and therapeutics development, and can be used to better understand hBM physiology, normal and impaired hematopoiesis, and hBM pathologies, including cancer metastasis, multiple myelomas, and BM failures.
Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20
Authors: Gadalla Mohamed Rasheed , Abrami Laurence , van der Goot F Gisou , Veit Michael 
Published: December 2019

AbstractHemagglutinin (HA), a glycoprotein of Influenza A viruses and its proton-channel M2 are site-specifically modified with fatty acids. Whereas two cysteines in the short cytoplasmic tail of HA contain only palmitate, stearate is exclusively attached to one cysteine located at the cytoplasmic border of the transmembrane region (TMR). M2 is palmitoylated at a cysteine positioned in an amphiphilic helix near the TMR. The enzymes catalyzing acylation of HA and M2 have not been identified, but zinc finger DHHC domain containing (ZDHHC) palmitoyltransferases are candidates. We used a siRNA library to knockdown expression of each of the 23 human ZDHHCs in HA-expressing HeLa cells. siRNAs against ZDHHC2 and 8 had the strongest effect on acylation of HA as demonstrated by acyl-RAC and confirmed by 3H-palmitate labelling. CRISPR/Cas9 knockout of ZDHHC2 and 8 in HAP1 cells, but also of the phylogenetically related ZDHHCs 15 and 20 strongly reduced acylation of group 1 and group 2 HAs and of M2, but individual ZDHHCs exhibit slightly different substrate preferences. These ZDHHCs co- localize with HA at membranes of the exocytic pathway in a human lung cell line. ZDHHC2, 8, 15 and 20 are not required for acylation of the hemagglutinin-esterase-fusion protein of Influenza C virus that contains only stearate at one transmembrane cysteine. Knockout of these ZDHHCs also did not compromise acylation of HA of Influenza B virus that contains two palmitoylated cysteines in its cytoplasmic tail. Results are discussed with respect to the acyl preferences and possible substrate recognition features of the identified ZDHHCs.
EffectorK, a comprehensive resource to mine for pathogen effector targets in the Arabidopsis proteome
Authors: González-Fuente Manuel , Carrère Sébastien , Monachello Dario , Marsella Benjamin G , Cazalé Anne-Claire , Zischek Claudine , Mitra Raka M , Rezé Nathalie , Cottret Ludovic , Mukhtar M Shahid , Lurin Claire , Noel Laurent D , Peeters Nemo 
Published: December 2019

Pathogens deploy effector proteins that interact with host proteins to manipulate the host physiology to the pathogen’s own benefit. However, effectors can also be recognized by host immune proteins leading to the activation of defense responses. Effectors are thus essential components in determining the outcome of plant-pathogen interactions. Despite major efforts to decipher effector functions, our current knowledge on effector biology is scattered and often limited. In this study, we conducted two systematic large-scale yeast two-hybrid screenings to detect interactions between Arabidopsis thaliana proteins and effectors from two vascular bacterial pathogens: Ralstonia pseudosolanacearum and Xanthomonas campestris . We then constructed an interactomic network focused on Arabidopsis and effector proteins from a wide variety of bacterial, oomycete, fungal and animal pathogens. This network contains our experimental data and protein-protein interactions from 2,035 peer-reviewed publications (48,200 Arabidopsis-Arabidopsis and 1,300 Arabidopsis-effector protein interactions). Our results show that effectors from different species interact with both common and specific Arabidopsis targets suggesting dual roles as modulators of generic and adaptive host processes. Network analyses revealed that effector targets, particularly effector hubs and bacterial core effector targets, occupy important positions for network organization as shown by their larger number of protein interactions and centrality. These interactomic data were incorporated in EffectorK, a new graph-oriented knowledge database that allows users to navigate the network, search for homology or find possible paths between host and/or effector proteins. EffectorK is available at www.effectork.org and allows users to submit their own interactomic data.
Integrating the production and the erection processes of pre-fabricated steel frames in building projects using phased lean management
Authors: Heravi Gholamreza , Kebria Majid Fazeli , Rostami Milad 
Published: December 2019

PurposeThe purpose of this paper is to investigate the effects of implementing value stream mapping (VSM), just in time (JIT), continuous flow and total productive maintenance (TPM) methods throughout production and erection processes of pre-fabricated steel frames (PSFs) of building projects.Design/methodology/approachAs phased lean management, after implementing the VSM technique, the JIT technique is implemented as first lean phase and the TPM and the continuous flow techniques are implemented as second lean phase. To evaluate the expected improvement of project performance due to reduce wastes by implementing lean techniques, discrete event simulation (DES) is utilized. In this research, an eight-story residential building project in Tehran, Iran, is studied.FindingsSimultaneous use of lean techniques to integrate production and erection processes of PSFs leads to the improvement of the performance of production and erection stages, significantly. The results indicate 43 and 17 percent reduction in PSFs production and erection processes time and cost, respectively.Research limitations/implicationsIn the present study, only the effects of implementing lean techniques on the production and erection of PSFs have been evaluated. However, it is also possible to apply these lean approaches and the key strategies to the other modular or pre-fabricated construction methods.Originality/valueThe main contribution to knowledge is improving the construction project performance by integrating the production and erection processes, using phased lean management through implementing lean techniques. The results of the current study provide valuable insight into the possibility of integrating and improving construction processes of pre-fabricated construction.
CIAC: adopting postconflict strategies
Authors: Hernández Juan Dario , Calderón Juan Camilo , Rodríguez Iván Felipe , Bayona Jaime Andrés 
Published: December 2019

Learning outcomes
Identify the influence of contextual variables (i.e. politics) in the strategy of a military organisation. Analyse and evaluate strategic change options of a military organisation. Decide on a strategic change from the resources and capabilities model.

Case overview/synopsis
Colombia Aeronautics Industry Corporation (CIAC) is a Colombian mixed economy company that commercialises, maintains and repairs civil and military aircraft and aeronautical components. The case presents the decision that the manager must make regarding a change in corporate strategy because of the entry into force of the peace agreement between the Government of Colombia and the Revolutionary Armed Forces of Colombia (FARC). This agreement assumes that the main line of business of the CIAC would be weakened (i.e. repair of military aircraft used in the internal armed conflict with FARC), because in a new peace scenario, the aircraft would not need as much maintenance as in the most critical stages of the conflict.

Complexity academic level
Master of Business Administration level (suggested courses: strategy, strategic management and organisational change). Undergraduate level (suggested courses: strategy and organisational change).

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 11: Strategy.
Crowdfunding success: the role of co-creation, feedback, and corporate social responsibility
Authors: Mastrangelo Leonardo , Cruz-Ros Sonia , Miquel-Romero Maria-Jose 
Published: December 2019

Purpose
The purpose of this paper is to investigate the factors that determine two forms of crowdfunding campaign success: success in securing the necessary financial resources and personal success in terms of the entrepreneur’s satisfaction. Specifically, it studies factors linked to the relationship between entrepreneurs and funders (co-creation and feedback) and factors linked to the campaign’s content (dimensions of corporate social responsibility (CSR)).

Design/methodology/approach
An empirical study of 52 crowdfunding entrepreneurs was conducted. Data were gathered using a structured questionnaire. Fuzzy-set qualitative comparative analysis was performed.

Findings
For financial and personal success, all factors, except the social dimension of CSR, are necessary conditions. Two configurations are sufficient for entrepreneurs to achieve financial success. The first configuration that is sufficient for personal success is the same as the first configuration for financial success. The second configuration for personal success is similar to the second configuration for financial success, except that it also includes financial success itself.

Research limitations/implications
Entrepreneurs should invest in CSR and seek to improve the quality of their relationships with their funders. Crowdfunding platforms should design and manage co-creation and feedback tools that are capable of providing deep knowledge of users’ opinions and concerns whilst generating value. The limitations of this study are that only the reward-based crowdfunding model was considered, and the data covered just two platforms.

Originality/value
This study contributes to the literature by presenting empirical analysis of the factors that influence financial success and personal success in reward-based crowdfunding. It examines aspects that strictly refer to the content of the project and aspects that refer to the entrepreneur–funder relationship. Specifically, the roles of the four dimensions of CSR were considered. Moreover, the fsQCA method provides a fresh approach to research in this area.
Diagnosis of delivery vulnerability in a logistics system for logistics risk management
Authors: Wu Pei-Ju , Chaipiyaphan Pattra 
Published: December 2019

PurposeDelivery vulnerability is a critically important theme in logistics risk management. However, while logistics service providers often collect and retain massive amounts of logistics data, they seldom utilize such information to diagnose recurrent day-to-day logistics risks. Hence, the purpose of this paper is to investigate delivery vulnerabilities in a logistics system using its own accumulated data.Design/methodology/approachThis study utilizes pragmatic business analytics to derive insights on logistics risk management from operations data in a logistics system. Additionally, normal accident theory informs the discussion of its management implications.FindingsThis study’s analytical results reveal that a tightly coupled logistics system can align with normal accident theory. Specifically, the vulnerabilities of such a system comprise not only multi-components but also interactive ones.Research limitations/implicationsThe tailored business analytics comprise a research foundation for logistics risk management. Additionally, the important research implications of this study’s analytical results arrived at via such results’ integration with normal accident theory demonstrate the value of that theory to logistics risk management.Practical implicationsThe trade-offs between logistics risk and logistics-system efficiency should be carefully evaluated. Moreover, improvements to such systems’ internal resilience can help to alleviate potential logistics vulnerabilities.Originality/valueThis pioneering analytical study scrutinizes the critical vulnerability issues of a logistics service provider and therefore represents a valuable contribution to the field of logistics risk management. Moreover, it provides a guide to retrieving valuable insights from existing stockpiles of delivery-vulnerability data.
Intrapreneurship: outside the project box and into the unknown
Authors: Feldmann Anna , Teuteberg Frank 
Published: December 2019

Purpose
This study aims to illustrate the current understanding of the concept of intrapreneurship by comparing it with that of a traditional project.

Design/methodology/approach
A meta-model was used to demonstrate how the two concepts overlap and what differences exist. Furthermore, a case study was conducted with an IT service provider from the banking sector in which 12 qualitative interviews with intrapreneurs were held and used to summarize the differences between projects and intrapreneurship initiatives from the intrapreneurs’ point of view.

Findings
This study identified two major differences: First, unlike in projects, the client has no clear objective in intrapreneurship; rather, only the sponsors maintain a general goal. Second, intrapreneurship allows for circumventing constraints and thus for working with more freedom and the possibility of failure.

Originality/value
This study used an explanatory model to summarize differences and clarify the concept of intrapreneurship.
Market power and stability of financial institutions: evidence from the Italian banking sector
Authors: Barra Cristian , Zotti Roberto 
Published: December 2019

Purpose
This paper aims to explore the relationship between bank market power and stability of financial institutions in Italy between 2001 and 2012. The authors first test the existence of a U-shaped relationship between market power and financial stability. Second, they regress the market share indicator on bank risk-taking to underline whether financial stability is affected by increasing or decreasing the market power of banks. Third, they explore whether this relationship is affected by the size, level of capitalization and credit insolvency of banks.

Design/methodology/approach
Relying on highly territorially disaggregated data at labor market areas level, the authors estimate the impact of bank market power and other explanatory variables on a proxy of risk taking behavior such as the banking “stability inefficiency” derived simultaneously from the estimation of a stability stochastic frontier. Bank market power is taken into account through an individual measure based on loans. Financial stability is calculated through the Z-score. The authors use, as risk-taking measure, the stability inefficiency whose estimation approach is the stochastic frontier analysis.

Findings
The empirical evidence shows that the inefficiency of financial stability is found to be U-shaped related with respect to the measure of market power. Bank size is an essential factor in explaining the relationship between bank market power and risk-taking. Cooperative banks have fewer incentives to gain market power to better perform in term of risks. The reform of the cooperative banks that took recently place in Italy is not supported by the data.

Originality/value
The relationship between bank market power and financial stability has been analyzed using a rich sample of cooperative, commercial and popular banks in Italy over the 2001-2012 period. The authors rely on labor market areas being sub-regional geographical areas where the bulk of the labor force lives and works. The paper investigates the market power-stability link considering both cooperative and non-cooperative banks. Indeed, specific attention has been paid on cooperative banks because of their mission in favor of the local community as only few studies, to the best of the authors’ knowledge, examine cooperative banking.
Defining inclusionary intelligence: a conceptual framework with a constructivist perspective
Authors: Berber Aykut 
Published: December 2019

PurposeThe purpose of this paper is to examine inclusion as subjectively created knowledge individuals generate through their interactions within a social environment. The main purpose is to introduce an inclusion-related conceptualisation of intelligence by means of which an individual evaluates, understands and engages in action in a work-setting in order to achieve efficient outcomes while feeling belonged and unique in a work-setting.Design/methodology/approachAiming at explaining a phenomenon and building a conceptual framework from the subjective perspective of a particular individual at work, such as a team member, the philosophical assumption embedded in this paper is social constructivism.FindingsA substantive conclusion drawn in this paper is the importance of an individual’s personal resources, such as optimism, resilience, self-efficacy and positive psychology, to evaluate situational conditions, and take necessary actions, which in turn determines how included that individual feels in a work-setting. Moreover, dyadic interactions are also substantial, and one-to-one communication in every dyad is essential for the “co-construction” of an individual’s inclusion.Research limitations/implicationsA scale development effort to explore and validate a construct for inclusionary intelligence and its domains can be suggested for future research.Practical implicationsWhile management literature, in general, lays much emphasis on managing diversity in team and organisations, this paper puts stress on the perspective of the individual at work.Originality/valueThe paper elaborates on the nature of inclusion with a social constructivist paradigm and approaches inclusion as a feeling, an experience, a subjective interpretation of one’s own position in a work-setting and an important predictor of one’s job satisfaction and well-being at work.
Are corporate social responsibility disclosures relevant for lenders? Empirical evidence from France
Authors: Hamrouni Amal , Uyar Ali , Boussaada Rim 
Published: December 2019

Purpose
The purpose of this paper is to test whether or not CSR disclosure (i.e. aggregate as well as its three sub-indicators) reduces the cost of debt for French corporations listed in the SBF 120 index between 2010 and 2015.

Design/methodology/approach
CSR disclosure ratings of firms were collected from the Bloomberg database under three dimensions such as environmental, social and governance (ESG). Then, a pooled regression analysis was run.

Findings
The results indicate that overall CSR disclosure score as a combination of ESG disclosure scores has a negative effect on the cost of debt (i.e. lowers the cost of debt). While environmental disclosure is negatively associated with the cost of debt, social disclosure is unexpectedly positively associated, and governance disclosure has an insignificant association with the cost of debt.

Research limitations/implications
The study has two main limitations. First, the analysis does not consider contractual constraints and obligations that might exist in debt contracts (Jung et al., 2018). Second, the analyses cover a specific time period (i.e. between 2010 and 2015) for a specific country (i.e. France) excluding utilities and the financial sector.

Practical implications
Overall, it is inferred from the results that financial markets for lenders take into account CSR disclosure when assessing the creditworthiness of borrowers. Specifically, environmental disclosure is the only subdimension of CSR that is influential on creditors’ decisions to offer favorable interest rates. In line with this outcome, companies can assess their processes and be more aligned with eco-friendly practices, and investors are particularly advised to invest in those types of firms.

Originality/value
This study extends scant literature on the association between CSR and the cost of debt by exploring how creditors treat CSR dimensions dissimilarly in granting loans to firms. The findings of this study have particular importance as financial debt is one of the most predominant forms of external financing.