bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precipitation of Relativistic Electrons Under Resonant Interaction With Electromagnetic Ion Cyclotron Wave Packets
Authors: Grach V. S. , Demekhov A. G. 
Published: February 2020

AbstractWe use numerical simulations to study the resonant interaction of relativistic electrons with rising‐frequency electromagnetic ion cyclotron (EMIC) wave packets in the
band. We find that precipitating fluxes are formed by quasi‐linear interaction and several nonlinear interaction regimes having opposite effects. In particular, the direct influence of Lorentz force on the particle phase (force bunching) decreases precipitation for particles with low equatorial pitch angles (up to 15–25°) and can even block it completely. Four other nonlinear regimes are possible: nonlinear shift of the resonance point, which can cause pitch angle drift in both directions; phase bunching that slightly increases pitch angle for untrapped particles; directed scattering that strongly decreases pitch angle for untrapped particles; and particle trapping by the wave field that decreases pitch angle. The evolution of the equatorial pitch angle distribution during several passes of particles through the wave packet is studied. The precipitating fluxes are evaluated and compared with theoretical estimates. We show that strong diffusion limit is maintained for a certain range of energies by a wave packet with realistic amplitude and frequency drift. In this case, the quasi‐linear theory strongly underestimates the precipitating flux. With increasing energy, the precipitating fluxes decrease and become close to the quasi‐linear estimates.
Simulations of MHD Wave Propagation and Coupling in a 3‐D Magnetosphere
Authors: Wright Andrew N. , Elsden Thomas 
Published: February 2020

AbstractA novel simulation grid is devised that is optimized for studying magnetohydrodynamic (MHD) wave coupling and phase mixing in a dipole‐like magnetic field. The model also includes flaring on the dawn and dusk flanks. The location of the magnetopause is quite general. In particular, it does not have to coincide with a coordinate surface. Simulations indicate the central role of global fast waveguide modes. These switch from being azimuthally standing in nature at noon, to propagating antisunward on the flanks. The field line resonances (FLRs) seen in the simulation results are three dimensional and not strictly azimuthally polarized. When a plume is present, the FLRs cross a range of 2 in
shell, and have a polarization that is midway between toroidal and poloidal.
Momentum Balance Across a Barrier Reef
Authors: Sous D. , Dodet G. , Bouchette F. , Tissier M. 
Published: February 2020

AbstractThis paper reports on a combined experimental and numerical study dedicated to barrier reefs hydrodynamics. A network of pressure sensors and velocity profilers has been deployed for more than 2 months over the Ouano reef barrier, New Caledonia. The primary aim of the study is to assess the relevance of the classical depth‐averaged momentum balance in such a complex and poorly documented environment. The combined analysis of experimental and numerical measurements reveals a specific hydrodynamic behavior contrasting with sandy beaches and fringing reefs. The cross‐reef current induced by wave breaking over the barrier reef plays an important role in the momentum budget, in particular through friction processes. The hydrodynamic behavior over the barrier reef is thus characterized by the progressive transition from a nearly classical beach type behavior on the forereef, where the gradient of radiation stress is balanced by a barotropic pressure gradient associated to the wave setup, to an open‐channel type regime, dominated by frictional head loss. The reef top wave setup shows a clear depth dependency mainly attributed to the forereef curvature. During extreme wave events, the measurements tend to indicate a transition toward a critical hydraulic regime above the reef top. The numerical simulations, involving a non‐hydrostatic wave‐resolving model coupled to a
turbulence model, highlight the vertical structure of the flow. Over the reef flat, a classical log‐layer profile is observed, in agreement with measurements, while above the forereef an anticlockwise circulation develops under the breaking zone.
Timing of Cenozoic Extension in the Southern Stillwater Range and Dixie Valley, Nevada
Authors: Colgan J. P. , Johnstone S. A. , Shuster D. L. 
Published: February 2020

AbstractThe Dixie Valley fault bounds the east side of the Stillwater Range in west‐central Nevada and last ruptured in 1954. Offset basalts indicate that slip began more recently than ~14 Ma, and prior work has interpreted the southern segment as an active low‐angle normal fault. Oligocene igneous rocks in the southern Stillwater Range were steeply tilted during large‐magnitude extension prior to ~14 Ma. To refine the timing of early extension and the onset of slip on the Dixie Valley fault, we collected two transects of samples for apatite fission track, apatite and zircon (U‐Th)/He (AHe and ZHe), and apatite 4He/3He thermochronometry. Apatite fission track ages from the Oligocene IXL pluton indicate rapid cooling ~18–14 Ma, and AHe and ZHe ages from the Cretaceous La Plata Canyon pluton indicate rapid cooling ~16–19 Ma. We interpret these data to record cooling during rapid extension. AHe ages from the IXL pluton are ~6–8 Ma and record cooling during slip on the Dixie Valley fault. We modeled these ages and 4He/3He spectra from one sample as the result of cooling during exhumation of a tilted fault block at a constant extension rate. The model predicts slip on the Dixie Valley fault beginning ~8 Ma. Although it does not constrain the initial fault dip, the model illustrates how a low‐angle fault requires a higher extension rate to reproduce cooling ages. Consequently, we prefer a high‐angle southern Dixie Valley fault for strain compatibility with the high‐angle northern segment.
Fibronectin-targeted dual-acting micelles for combination therapy of metastatic breast cancer
Authors: Gong Zhuoran , Chen Min , Ren Qiushi , Yue Xiuli , Dai Zhifei 
Published: February 2020

AbstractStage IV breast cancer, which has a high risk of invasion, often develops into metastases in distant organs, especially in the lung, and this could threaten the lives of women. Thus, the development of more advanced therapeutics that can efficiently target metastatic foci is crucial. In this study, we built an dual-acting therapeutic strategy using micelles with high stability functionalized with fibronectin-targeting CREKA peptides encapsulating two slightly soluble chemotherapy agents in water, doxorubicin (D) and vinorelbine (V), which we termed C-DVM. We found that small C-DVM micelles could efficiently codeliver drugs into 4T1 cells and disrupt microtubule structures. C-DVM also exhibited a powerful ability to eradicate and inhibit invasion of 4T1 cells. Moreover, an in vivo pharmacokinetics study showed that C-DVM increased the drug circulation half-life and led to increased enrichment of drugs in lung metastatic foci after 24 h. Moreover, dual-acting C-DVM treatment led to 90% inhibition of metastatic foci development and reduced invasion of metastases. C-DVM could potentially be used as a targeted treatment for metastasis and represents a new approach with higher therapeutic efficacy than conventional chemotherapy for stage IV breast cancer that could be used in the future.
Mixotrophy in marine picocyanobacteria: use of organic compounds by Prochlorococcus and Synechococcus
Authors: Muñoz-Marín M C , Gómez-Baena G , López-Lozano A , Moreno-Cabezuelo J A , Díez J , García-Fernández J M 
Published: February 2020

Abstract
Marine picocyanobacteria of the Prochlorococcus and Synechococcus genera have been longtime considered as autotrophic organisms. However, compelling evidence published over the last 15 years shows that these organisms can use different organic compounds containing key elements to survive in oligotrophic oceans, such as N (amino acids, amino sugars), S (dimethylsulfoniopropionate, DMSP), or P (ATP). Furthermore, marine picocyanobacteria can also take up glucose and use it as a source of carbon and energy, despite the fact that this compound is devoid of limiting elements and can also be synthesized by using standard metabolic pathways. This review will outline the main findings suggesting mixotrophy in the marine picocyanobacteria Prochlorococcus and Synechococcus, and its ecological relevance for these important primary producers.
Topological behavior and Zeeman splitting in trigonal PtBi2-x single crystals
Authors: Xing Lingyi , Chapai Ramakanta , Nepal Roshan , Jin Rongying 
Published: February 2020

AbstractTransition-metal dipnictide PtBi2 exhibits rich structural and physical properties with topological semimetallic behavior and extremely large magnetoresistance (XMR) at low temperatures. We have investigated the electrical and magnetic properties of trigonal-phase PtBi2-x single crystals with x ~ 0.4. Profound de Haas–van Alphen (dHvA) and Shubnikov-de Haas (SdH) oscillations are observed. Through fast Fourier transformation (FFT) analyses, four oscillation frequencies are extracted, which result from α, β, γ, and δ bands. By constructing the Landau fan diagram for each band, the Berry phase is extracted demonstrating the non-trivial nature of the α, β, and δ bands. Despite Bi deficiency, we observe the Zeeman splitting in dHvA and SdH oscillations under moderate magnetic field and the moderate Landé g factor (4.97–6.48) for the α band. Quantitative analysis of the non-monotonic field dependence including the sign change of the Hall resistivity suggests that electrons and holes in our system are not perfectly compensated thus not responsible for the XMR effect.
Establishment of Structure-Function Relationship of Tissue Inhibitor of Metalloproteinase-1 for Its Interaction with CD63: Implication for Cancer Therapy
Authors: Warner Richard B. , Najy Abdo J. , Jung Young Suk , Fridman Rafael , Kim Seongho , Kim Hyeong-Reh Choi 
Published: February 2020

AbstractTissue inhibitor of metalloproteinases-1 (TIMP-1) is a pleiotropic protein, promoting both tumor-suppressive and tumor-promoting activities. While TIMP-1 is primarily known as an endogenous inhibitor of matrix metalloproteinases (MMPs) and thus associated with tumor cell invasion, clinical studies demonstrated increased expression of TIMP-1 and its association with poor prognosis in cancer. Non-MMP-inhibitory and oncogenic functions of TIMP-1 are mediated by induction of intracellular signaling via its cell surface receptor CD63, a tetraspanin. The present study investigates the structure-function relationship of TIMP-1 for its interaction with CD63, which may eventually help design a novel approach for targeting TIMP-1’s pro-oncogenic activity without interfering its tumor suppressive MMP-inhibitory function. Importantly, our analysis includes TIMP-1/CD63 interactions at the cell surface of live cells. Here, we demonstrate that the 9 C-terminal amino acid residues of TIMP-1 and the large extracellular loop of CD63 are required for their interaction. Considering that the N-terminal half of TIMP-1 is sufficient for TIMP-1’s MMP-inhibitory activity, we propose that those C-terminal amino acid residues are a potentially targetable motif of TIMP-1 oncogenic activity. As a proof of concept, we present the potential for the development of neutralizing antibodies against the C-terminal motif of TIMP-1 for disruption of TIMP-1 interaction with CD63 and the subsequent signal transduction.
Observation of an exotic state of water in the hydrophilic nanospace of porous coordination polymers
Authors: Ichii Tomoaki , Arikawa Takashi , Omoto Kenichiro , Hosono Nobuhiko , Sato Hiroshi , Kitagawa Susumu , Tanaka Koichiro 
Published: February 2020

AbstractFundamental understanding of the confinement of water in porous coordination polymers (PCPs) is important not only with respect to their application, such as in gas storage and separation, but also for exploring confinement effects in nanoscale spaces. Here, we report the observation of water in an exotic state in the well-designed hydrophilic nanopores of PCPs. Single-crystal X-ray diffraction finds that nanoconfined water has an ordered structure that is characteristic in ices, but infrared spectroscopy reveals a significant number of broken hydrogen bonds that is characteristic in liquids. We find that their structural properties are quite similar to those of solid-liquid supercritical water predicted in hydrophobic nanospace at extremely high pressure. Our results will open up not only new potential applications of water in an exotic state in PCPs to control chemical reactions, but also experimental systems to clarify the existence of solid-liquid critical points.
Transient domains of ordered water induced by divalent ions lead to lipid membrane curvature fluctuations
Authors: Tarun O. B. , Okur H. I. , Rangamani P. , Roke S. 
Published: February 2020

AbstractCell membranes are composed of a hydrated lipid bilayer that is molecularly complex and diverse, and the link between molecular hydration structure and membrane macroscopic properties is not well understood, due to a lack of technology that can probe and relate molecular level hydration information to micro- and macroscopic properties. Here, we demonstrate a direct link between lipid hydration structure and macroscopic dynamic curvature fluctuations. Using high-throughput wide-field second harmonic (SH) microscopy, we observe the formation of transient domains of ordered water at the interface of freestanding lipid membranes. These domains are induced by the binding of divalent ions and their structure is ion specific. Using nonlinear optical theory, we convert the spatiotemporal SH intensity into maps of membrane potential, surface charge density, and binding free energy. Using an electromechanical theory of membrane bending, we show that transient electric field gradients across the membrane induce spatiotemporal membrane curvature fluctuations.
Consolidação dos tubérculos na artroplastia reversa do ombro após fratura proximal do úmero: Existe melhoria nos resultados funcionais?
Authors: Barros Luís Henrique , Figueiredo Sérgio , Marques Manuel , Rodrigues Claudia , Ramos Joaquim , Claro Rui 
Published: February 2020

Resumo
Objetivo Comparar os resultados funcionais entre pacientes com fratura complexa do úmero proximal submetidos a artroplastia reversa com tubérculos consolidados e tubérculos não consolidados. O objetivo secundário foi determinar a taxa de consolidação dos tubérculos com este tipo de prótese.
Métodos Estudo de tipo coorte, retrospectivo, com coleta prospectiva de dados. No total, 28 pacientes cumpriram os critérios de inclusão: idade superior a 65 anos, prótese reversa do ombro por fratura complexa do úmero proximal (3 ou 4 partes, segundo Neer), e tempo de seguimento mínimo de 24 meses. Aos seis meses, todos os pacientes foram avaliados radiograficamente quanto à consolidação dos tubérculos e divididos em dois grupos: grupo com tubérculos consolidados e grupo com tubérculos não consolidados. A avaliação funcional realizou-se segundo o sistema de pontuação de Constant, da amplitude de movimento ativo, e da Escala Visual Analógica (EVA) à data da última consulta. Registaram-se todas as complicações.
Resultados A consolidação dos tubérculos ocorreu em 21 pacientes (76,3%). Verificou-se diferenças estatisticamente significativas no sistema de pontuação de Constant (p < 0.001), elevação anterior (p = 0.020), rotação interna (p = 0.001) e externa (p = 0.003), quando se comparou o grupo dos tubérculos consolidados com o grupo dos tubérculos não consolidados. Não houve diferenças significativas na EVA entre os 2 grupos.
Conclusão A consolidação dos tubérculos traduz uma melhoria dos resultados funcionais em pacientes submetidos a artroplastia reversa do ombro como tratamento de fraturas complexas do úmero proximal em idosos.
¿Tienen los Hábitos de Vida y de Alimentación Impacto en la Calidad Seminal?
Authors: Gómez Gutiérrez Alejandra María , Gómez Ramírez Briana D. , Cardona Maya Walter D. 
Published: February 2020

ResumenEn los últimos años, se ha reportado en la literatura científica un declive en la calidad seminal. La significancia biológica de ese evento podría estar relacionada con la reducción en la fertilidad masculina o con el aumento del riesgo de enfermedades en la descendencia. La occidentalización en el estilo de vida, caracterizado por el aumento del peso corporal, el sedentarismo, el uso de cigarrillo, la ingesta de alimentos ricos en grasas y sodio y la reducción en la ingesta de alimentos fuente de fibras y antioxidantes, pudieran estar implicados en esos resultados. A su vez, cambios en el estilo de vida, que conduzcan a una reducción de peso corporal, de la ingesta de grasa y sodio, a un mejor estado antioxidante y a un aumento de la ingesta de fibra, se han asociado a mejores parámetros seminales. Por lo tanto, la alimentación basada en plantas o vegetariana, podría ser una estrategia válida para mejorar el estado nutricional y la salud masculina.
Clinical Profile of Patients with Head and Neck Amyloidosis: A Single-Institution Retrospective Chart Review
Authors: Singh Anup , Haq Mubashshirul , Gautam Poonam , Gautam Dheeraj , Handa Aru C. , Handa Kumud K. 
Published: February 2020

Abstract
Introduction Isolated amyloidosis involving the head and neck is a rare entity. The pathophysiology of the localized disease appears to be distinct from that of the systemic counterpart. Systemic progression of the localized disease is unusual, and the prognosis of the localized form is excellent.
Objective To describe the demographic and clinicopathological characteristics of patients presenting with localized head and neck subsite amyloidosis.
Methods A retrospective chart review of the patients with head and neck amyloidosis identified by the electronic search of the electronic database of the Departments of Pathology and Otorhinolaryngology was performed. The various demographic and clinical data were tabulated.
Results In total, seven patients (four females, three males) with localized head and neck amyloidosis (three supraglottic, three lingual and one sinonasal) were identified. Six patients had AL-amyloid deposits, and one patient had AA-amyloid deposits. Supraglottic involvement and that of the base of the tongue were treated surgically using CO2 laser, and these patients were disease-free at the last follow-up. The patient with sinonasal amyloidosis experienced symptom recurrence after six months of the functional endoscopic sinus surgery. All of the patients were screened for systemic amyloidosis with abdominal fat pad biopsy, and were found to be free of systemic spread.
Conclusion Isolated head and neck amyloidosis, as opposed to systemic amyloidosis, has an excellent prognosis in terms of survival. Therefore, systemic amyloidosis should be excluded in all cases. The treatment of choice remains surgical excision; however, watchful waiting may be a suitable strategy for mild symptoms or for cases in which the disease was discovered incidentally.
Sweating the connection of uniform colours and success in sport: No evidence for the red win effect in elite women's NCAA basketball
Authors: Goldschmied Nadav , Spitznagel Carson 
Published: February 2020

AbstractEfforts to research the link between uniform colours and performance in sport have gained momentum in recent years demonstrating a red superiority effect. The current investigation identified a gender gap in participation between laboratory experimental studies of performance, which are dominated by women participants, and archival game analysis research, which is almost exclusively conducted in elite men's sports. To address this disparity, we conducted the first dedicated exploration of uniform colours with women's American collegiate basketball teams during the national annual tournament (NCAA) in a period spanning eight seasons (2012–19). In contrast to the evidence from experimental research, we failed to detect an effect and the results remained null when several colours were tested and ranking was considered. Based on the findings, we conclude with mounting confidence that uniform colours do not exert influence over winning in relatively long‐duration, low aggression team sports with substantial physical contact. We discuss the results in relationship to the colour‐in‐context theory (Elliot, A. J., & Maier, M. A. (2012). Colour‐in‐context theory. In Advances in experimental social psychology (Vol. 45, pp. 61–125). Academic Press.) and highlight its shortcomings pertaining to sex as a moderator.
Highly charged ECR ion source development at IMP
Authors: Sun L , Zhao H W , Lu W , Guo J W , Li L X , Shen Z , Li L B , Huang W , Zhang X Z , Ma H Y , Yang Y , Li J Q , Cao Y , Zhang W H , Fang X , Ma Y M , Feng Y C , Wu B M , Wu W , Ma L Z 
Published: February 2020

Abstract
Highly charged ECR ion source development plays an important role in the heavy ion accelerators advancement at IMP, such as HIRFL upgrade, heavy ion treatment complex HIMM, future heavy ion facility HIAF, and so on. As requested by those projects, many high performance highly charged ECR ion sources with different technologies have been built, or under development. The representative ion sources are superconducting ECR ion sources SECRAL and recently built SECRAL-II, room temperature LECR4 ion source with an innovative evaporative cooling method, permanent magnet ECR ion sources of LAPECR series, and a 45 GHz 4th generation ECR ion source FECR. In this talk, a general review of highly charged ECR ion sources will be presented. The typical performances, operation status, as well as the future developments will be dis-cussed.
Potential shifts in the aboveground biomass and physiognomy of a seasonally dry tropical forest in a changing climate
Authors: Castanho Andrea D A , Coe Michael T , Brando Paulo , Macedo Marcia , Baccini Alessandro , Walker Wayne , Andrade Eunice M 
Published: February 2020

Abstract
Seasonally dry tropical forests (SDTFs) account for one-third of the interannual variability of global net primary productive (NPP). Large-scale shifts in dry tropical forest structure may thus significantly affect global CO2 fluxes in ways that are not fully accounted for in current projections. This study quantifies how changing climate might reshape one of the largest SDTFs in the world, the Caatinga region of northeast Brazil. We combine historical data and future climate projections under different representative concentration pathways (RCPs), together with spatially explicit aboveground biomass estimates to establish relationships between climate and vegetation distribution. We find that physiognomies, aboveground biomass, and climate are closely related in the Caatinga—and that the region’s bioclimatic envelope is shifting rapidly. From 2008–2017, more than 90% of the region has shifted to a dryer climate space compared to the reference period 1950–1979. An ensemble of global climate models (based on IPCC AR5) indicates that by the end of the 21st century the driest Caatinga physiognomies (thorn woodlands to non-vegetated areas) could expand from 55% to 78% (RCP 2.6) or as much as 87% (RCP8.5) of the region. Those changes would correspond to a decrease of 30%–50% of the equilibrium aboveground biomass by the end of the century (RCP 2.6 and RCP8.5, respectively). Our results are consistent with historic vegetation shifts reported for other SDTFs. Projected changes for the Caatinga would have large-scale impacts on the region’s biomass and biodiversity, underscoring the importance of SDTFs for the global carbon budget. Understanding such changes as presented in this study will be useful for regional planning and could help mitigate their negative social impacts.