bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic Segmentation of Abdominal Aortic Aneurism (AAA) By Using Active Contour Models
Authors: Kosasih Rifki 
Published: July 2020

Abdominal aortic aneurysm (AAA) is a disease that is caused by dilation of the aortic wall. Dilation of the aortic wall will affect the size of the diameter of lumen and the aorta. In this study we use T1 and T2 images on 4 patients with AAA which generated from MR Imaging to calculate the diameter of the abdominal aortic aneurysm (AAA). To calculate the diameter of lumen and the aorta, the first step is image registration using Laplacian eigenmap method. After that we propose an automatic segmentation method on region of the aorta by using active contour models to get the contour of lumen and the aorta. The last step, we calculate the diameter of lumen and the aorta by using contour of lumen and the aorta. In our experiment, active contour model is very good method for segmentation AAA. In the result, our proposed model give the accuracy rate of lumen is 96.41% and accuracy rate of aorta is 95.22%.
Acute neonatal Listeria monocytogenes infection causes long-term, organ-specific changes in immune cell subset composition
Authors: Zou Mangge , Yang Juhao , Wiechers Carolin , Huehn Jochen 
Published: July 2020

AbstractListeria monocytogenes(Lm) is a food-borne pathogen with a high chance of infecting neonates, pregnant women, elderly and immunocompromised individuals.Lminfection in neonates can cause neonatal meningitis and sepsis with a high risk of severe neurological and developmental sequelae and high mortality rates. However, whether an acute neonatalLminfection causes long-term effects on the immune system persisting until adulthood has not been fully elucidated. Here, we established a neonatalLminfection model and monitored the composition of major immune cell subsets at defined time points post infection (p.i.) in secondary lymphoid organs and the intestine. Twelve weeks p.i., the CD8+T cell population was decreased in colon and mesenteric lymph nodes (mLNs) with an opposing increase in the spleen. In the colon, we observed an accumulation of CD4+and CD8+effector/memory T cells with an increase of T-bet+T helper 1 (Th1) cells. In addition, 12 weeks p.i. an altered composition of innate lymphoid cell (ILC) and dendritic cell (DC) subsets was still observed in colon and mLNs, respectively. Together, these findings highlight organ-specific long-term consequences of an acute neonatalLminfection on both the adaptive and innate immune system.
MobilitÃ© GÃ©ographique Intraorganisationnelle au Togo : Une Etude Exploratoire des Perceptions et des VÃ©cus
Authors: Kazimna Pazambadi 
Published: July 2020

Lâ€™objectif de la prÃ©sente Ã©tude est dâ€™analyser les perceptions et le vÃ©cu de la mobilitÃ© gÃ©ographique intra-organisationnelle des travailleurs au Togo. Pour ce faire un questionnaire construit a Ã©tÃ© administrÃ© Ã 45 travailleurssalariÃ©s togolais issus des villes et des zones rurales. Ces travailleurs ont fait lâ€™objet dâ€™une mobilitÃ© gÃ©ographique au moins. Les rÃ©sultats obtenus montrent quâ€™il existe des perceptions de freins Ã la mobilitÃ© des salariÃ©s togolais. Ces freins sont liÃ©s entre autres Ã lâ€™Ã¢ge, Ã la situation familiale, Ã lâ€™absence de politique de mobilitÃ©, et aux difficultÃ©s dâ€™accÃ¨s Ã certaines zones. Ce qui entraine, dans les vÃ©cus de certains travailleurs, le stress et le sentiment dâ€™injustice. Toutefois, lâ€™Ã©tude rÃ©vÃ¨le Ã©galement que la mobilitÃ© gÃ©ographique, qui est un outil de management des ressources humaines et un facteur de rÃ©duction de la disparitÃ© entre villes, prÃ©fectures et rÃ©gions, prÃ©sente aussi des opportunitÃ©s de dÃ©veloppement professionnel (promotion).
The objective of this study is to analyze the perceptions and real-life experience of intra-organizational geographic mobility of workers in Togo. To do this, a constructed questionnaire was administered to 45 Togolese workers and salaried workers from cities and rural areas. These workers have been subject to at least geographic mobility. The results obtained show that there are perceptions of obstacles to the mobility of Togolese employees. These obstacles are linked, among other things, to age, family situation, lack of a mobility policy, difficulties in accessing certain areas. This leads to the stress and the feeling of injustice experienced by certain workers surveyed. However, the study also reveals that geographic mobility, which is a human resource management tool and a factor in reducing the disparity between cities, prefectures and regions, also presents opportunities for professional development (promotion).
Lâ€™analyse Qualitative Inorganique Dans le Curriculum Formel Marocain et Chez Les Futurs Enseignants de Physique-Chimie en Cycle Secondaire CollÃ©gial
Authors: Bouabdallah Ibrahim 
Published: July 2020

Lâ€™analyse qualitative inorganique, une mÃ©thode dâ€™analyse chimiquequalitative permettant dâ€™identifier les constituants dâ€™une substance sert Ã illustrer les phÃ©nomÃ¨nes chimiques en cycle secondaire collÃ©gial. Les futursenseignants sont confrontÃ©s Ã des exigences particuliÃ¨res en termes deconnaissances relatives Ã lâ€™objet de savoir, pour pouvoir assurer latransposition didactique. Cet article vise, dâ€™une part, lâ€™examen des contenus Ã enseigner en chimie aux apprenants du secondaire collÃ©gial, et dâ€™autre part, ladÃ©termination du niveau dâ€™acquisition des connaissances relatives Ã lâ€™analysequalitative inorganique chez les futurs enseignants. Pour ce faire, une analyseexhaustive du curriculum formel marocain, suivie dâ€™un questionnaire ouvertsoumis Ã cinquante-huit futurs enseignants, ont Ã©tÃ© menÃ©s pour collecter lesdonnÃ©es. Les rÃ©sultats concernant le curriculum formel montrent lâ€™absence dethÃ¨mes consacrÃ©s Ã ce champ disciplinaire qui entretient une corrÃ©lationimplicite avec les activitÃ©s dâ€™enseignement. La dissolution et lâ€™identificationdu gaz formÃ© ne constituent pas un obstacle pour les futurs enseignants.Cependant, ils Ã©prouvent dâ€™Ã©normes difficultÃ©s pour expliquer les rÃ©actionsmises en jeu lors de lâ€™action de la substance inconnue avec les rÃ©actifs. Enplus, leur savoir-faire pratique rÃ©vÃ¨le une lacune pour proposer un montageexpÃ©rimental de production du sulfure dâ€™hydrogÃ¨ne.
The inorganic qualitative analysis, a method of analytical chemistry foridentifying the constituents of a substance, is used to illustrate chemicalphenomenaâ€™s in the college secondary cycle. Future teachers are confrontedwith particular requirements in terms of knowledges related to the knowledgeobject in order to be able to ensure didactic transposition. This article aims, onone hand, to examine the chemistry contents to be taught in secondary collegeschool, and on the other hand, to determine the future teachersâ€™ level ofinorganic qualitative analysis knowledge acquisition. To achieve this, anexhaustive analysis of the formalMoroccan curriculum, followed by an openendedquestionnaire submitted to fifty-eight future teachers, were used tocollect the data. The results concerning the formal curriculum show theabsence of themes related to this disciplinary field which has correlate withthe teaching activities. The dissolution and identification of the formed gas didnot appear to be an obstacle for the future teachers. However, they foundseveral difficulties to explain the reactions between the unknown substanceand reagents. In addition, their practical knowledge reveals an insufficiency topropose an experimental setup to produce the hydrogen sulfide.
Hernie De Amyand Compliquee De Gangrene De Fournier : A Propos Dâ€™un Cas Et Revue De La Litterature
Authors: Geraldo Raouf Fayisall , Matendo Hugues Ndasu , Musteata Liviu , Krasovski ValÃ©riu , Nitu Valentin , Gastaud Thierry , Cattan Fabrice 
Published: July 2020

La hernie de Amyand se dÃ©finit par l'incarcÃ©ration de l'appendice vermiculaire dans le sac herniaire. Elle constitue une entitÃ© rare. Nous rapportons le cas dâ€™un patient de 75ans, Ã©thylique, dÃ©nutri et porteur dâ€™une cardiopathie ischÃ©mique stentÃ© et sous traitement anticoagulant, admis pour une tumÃ©faction douloureuse et chaude localisÃ©e en rÃ©gion inguinale droite Ã©voluant depuis cinq jours. Le bilan biologique rÃ©vÃ©lait un syndrome infectieux et des troubles sÃ©vÃ¨res de lâ€™hÃ©mostase. Le scanner a objectivÃ© un appendice perforÃ© au sein du sac herniaire droit et un thrombus intraventriculaire gauche. Lâ€™Ã©volution sâ€™est faite vers une gangrÃ¨ne de Fournier. AprÃ¨s correction des troubles hÃ©mostatiques, la prise en charge chirurgicale a consistÃ© en lâ€™appendicectomie, drainage par laparotomie mÃ©diane associÃ©e Ã une orchidectomie droite sur un testicule nÃ©crosÃ© avec exÃ©rÃ¨se jusquâ€™en zone saine de la peau scrotale. MalgrÃ© des constantes stables en per-opÃ©ratoire, le patient a prÃ©sentÃ© un arrÃªt cardiaque en post-opÃ©ratoire immÃ©diat, rÃ©animÃ© sans succÃ¨s.
Amyand hernia is defined by the presence of appendix herniating into the deep inguinal ring. Itâ€™s a rare condition. We report the case of a 75-yearold male patient, presenting alcoholism, undernutrition and ischemic cardiopathy which required angioplasty and anticoagulation, admitted for a painful and hot swelling in right inguinal region evolving for five days. Blood analysis revealed infectious syndrome and important hemostasis disorders. Computed Tomography scan showed perforated appendix herniating through inguinal ring associated to a thrombus in the left ventricle. The evolution was marked by a Fournierâ€™s gangrene. After getting the normalization of the hemostasis values, a laparotomy was performed for appendicectomy, drainage. The right testicle, necrotized, was removed, with a wide debridement of the fasciitis. Although the parameters were stable during the surgery, the patient presented
Restless abdomen: a spectrum or a phenotype variant of restless legs syndrome?
Authors: Wang Xi-Xi , Zhu Xiao-Ying , Wang Zan , Dong Jian-Wei , Ondo William G. , Wu Yun-Cheng 
Published: July 2020

Abstract
Background: With the growing awareness of restless legs syndrome (RLS), sensory disorders similar to RLS initially confined to the arms, abdomen, and perineum are more and more being recognized. One of them is restless abdomen, which refers to a restless sensation in abdomen. Our study is designed to evaluate the clinical phenotype of restless abdomen and investigate its relationship with RLS. Methods: We enrolled 10 patients with restless abdomen according to the RLS diagnostic criteria. Laboratory examinations were performed to exclude mimics and notable comorbidities. Results: All 10 patients had RLS like symptoms in the abdomen and otherwise satisfied all other RLS diagnostic criteria, and responded to dopaminergic therapy. Conclusions: Neurologists should be aware of the RLS-related restlessness that can occur in extra-leg anatomy in the absence of episodes of worsening or augmentation of restlessness.
TUG1 enhances high gluose impaired endothelial progenitor cell function via miR-29c-3p/PDGF-BB/Wnt signaling
Authors: Li Yang , Zhi Kangkang , Han Shilong , Li Xue , Li Maoquan , Lian Weishuai , Zhang Haijun , Zhang Xiaoping 
Published: July 2020

Abstract
Background: Diabetes is associated with the dysfunction of endothelial progenitor cells (EPCs), characterized as impaired angiogenesis, a phenomenon thought to be involved in the development of diabetic foot. LncRNA plays an essential role in microvascular dysfunction and signaling pathways in patients with diabetes. LncRNA taurine upregulated gene 1 (TUG1) participates in angiogenesis in various cells. However, the mechanisms of TUG1 activity in EPCs have not been elucidated. Methods: We isolated and then characterized EPCs from the peripheral blood of mice using immunofluorescence and flow cytometry. Western blot detected the wnt/β-catenin pathway in high glucose treated EPCs. Bioinformatics analysis predicted a putative binding site for TUG1 on miR-29c-3p. The interactions among TUG1, platelet-derived growth factor-BB (PDGF-BB) and miR-29c-3p were analyzed by luciferase assays. In vivo, diabetic mouse ischemic limb were treated with normal saline or TUG1 overexpression lentiviruses. Results: We found that EPC migration, invasion and tube-formation declined after treatment with high-glucose, but improved with TUG1 overexpression. Mechanically, wnt/β-catenin pathway and autophagy were involved in the function of TUG1 overexpression in high glucose treated EPCs. Moreover, TUG1 regulates the PDGF-BB/wnt pathway and function of high glucose treated EPCs via miR-29c-3p. In vivo, injection of TUG1 lentivirus in a diabetic mouse ischemic limb model stimulated angiogenesis. Conclusions: Our findings suggest that TUG1 restores high glucose treated EPC function by regulating miR-29c-3p/PDGF-BB/Wnt signaling.
Numerical analysis of asphalt concrete milling process based on multicomponent modeling
Authors: Zhou Liqun , Liu Yi , Wang Zhennan , Li Yuping , Zhang Kui , Zhang Gaofeng 
Published: July 2020

Abstract
In this paper, according to the different physical properties of each component of asphalt concrete, a finite element simulation is used to build a mechanical constitutive model for the concrete cutting processes. When the machine cutter contacts different aggregate particles, the variation rules of mechanical information are obtained and studied. The main research work includes: (1) The track and force of the tool in the cutting process are defined, and then the track equation of the tool tip and the calculation formula of friction resistance are obtained. The relationship between the friction resistance and working parameters is clarified. (2)From the multicompont modeling, the internal components of asphalt concrete are refined, and the mechanical properties of asphalt mortar and aggregate particles are set up. Random feeding of different aggregate particles in asphalt concrete specimens is completed by using Python software and Monte carlo method. After the simulation, the results are imported into numerical software to generate the variation curve of tool friction resistance, so as to obtain the rule of its change with various factors, and according to the above studies, the optimal working parameters combination of the milling planer are summarized.
BION-2: Predicting Positions of Non-Specifically Bound ions on Protein Surface by a Gaussian-based Treatment of Electrostatic Environment
Authors: Shashikala Mihiri , Chakravorty Arghya , Pandey Shailesh , Alexov Emil 
Published: July 2020

Abstract
Background: Ions play significant roles in biological processes - they may specifically bind to a protein site or bind non-specifically on its surface. Though, the role of specifically bound ions range from actively providing structural compactness via coordination of charge-charge interactions to numerous enzymatic activities, non-specifically surface-bound ions are also crucial to maintaining a protein’s stability, responding to pH and ion concentration changes and contributing to other biological processes. However, experimental determination of positions of non-specifically bound ions is not trivial since they may have low residential time and experience significant thermal fluctuation of their positions. Results: Here we report a new release of a computational method, the BION-2 method, that predicts positions of non-specifically surface-bound ions. The BION-2 utilizes the Gaussian-based treatment of ions within the framework of the modified Poisson-Boltzmann equation, that does not require a sharp boundary between the protein and water phase. Thus, the predictions are done by the balance of the energy of interaction between the protein charges and the corresponding ions, and the de-solvation penalty of the ions as they approach the protein. Conclusions: The BION-2 is tested against experimentally determined ion’s positions, with both X-ray and NMR determined positions, and it is demonstrated that it outperforms the old BION and molecular dynamics tools. The BION-2 is available as a web server as well.
Quantum Signature of Anisotropic Singularities in Hydrogen Bond Breaking of Water Dimer
Authors: Ali Md. Rejwan , Mezei Mihaly 
Published: July 2020

Abstract
Molecular simulations from small molecules to large bio-macromolecules and polymer systems are routinely used to simulate thermodynamics properties of interests by molecular mechanics-based potentials. In a recent paper, via three different semi-empirical methods, we reported quantum singularities in molecular mechanics torsion potentials as signature of chemical bond break-up process revealed under experimental X-ray as broken chemical moieties. In this present work, applying first principle methods of Hartree-Fock, Density Functional as well as Moller-Plesset techniques we have reconfirmed the previous general predictions of singularities in the torsion potential for the case of water dimer that connects two water monomers by weak hydrogen bond. Due to quantum nature of chemical bond breaking process leading to break-point conditions in otherwise connected molecular topology aided by molecular mechanics based potentials, the singularities are also suggestive of large forces as onset in the bond-breaking process. We have presented the details of these novel interesting findings in this paper. These results of quantum singularities can have significant impacts to improve current force fields and can open up new areas we define as “Fracture Molecular Mechanics” or “Fracture Force Field” in overlap regions of molecular and quantum mechanics based approaches to explore and account for chemical bond-breaking mechanisms in molecular simulation techniques.
Beyond COVID-19 Pandemic: A Systematic Review of the Role of Global Health in the Evolution and Practice of Corporate Social Responsibility
Authors: Antwi Henry Asante 
Published: July 2020

Abstract
BackgroundGlobal health crisis continues to drive the dynamics of corporate social responsibility across industries with self-perpetuating momentum. From a historical point of view, more than a century of immense corporate fecundity has formed the ecological conditions and shaped current understanding of the effect of global health on CSR. The HIV-AIDS, the Opiod, the environmental health, obesity and many other health crises have become a synergistic platform to enhance corporate offer and competitiveness through voluntary support and care for victims. This review therefore revisits the core issues in global health that continues to drive CSR across industries. It seek to establish the driving dynamics of healthcare in CSR engagement, identify its contribution to theory and practice and predict the future pattern as corporate enterprises navigate new CSR strategies through the epochal challenges presented by COVID-19MethodThe procedures and set of activities outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart was used to carry out the systematic review.ResultsThe analysis has shown that from time immemorial, global health has played a major role in the development and implementation of CSR among enterprises. The HIV-AIDS pandemic, the environmental health crises are two dominant global health crisis that have shaped and continue to drive CSR activities in numerous work places but COVID-19 presents a deeper challenge for enterprise. These diseases are capable of self-mobilising advocates at the international level, have a grabbing value that reaches the corridors of power in international humanitarian organisations and multinational enterprises.ConclusionsThe impact of the novel coronavirus (COVID-19) on CSR is predicted to be monumental and uncommon. The call for a radical overhaul of health and safety measures in enterprises is now urgent than ever before. There is a moral obligation for enterprises to reform current risk assessments and collaborate more deeply with state agencies to invest in the health and safety inspections at the world place.
COVID-19 Lesion Segmentation using Lung CT Scan Images: Comparative Study based on Active Contour Models
Authors: Akbari Younes , Hassen Hanadi , Al-maadeed Somaya , Zughaier Susu M. 
Published: July 2020

Abstract
Pneumonia is a lung infection threaten that threats all age groups. In this paper, using CT scans images, we used active contour models to evaluate and determine pneumonia infection caused by the Coronavirus disease (COVID-19). A background of active contour models (ACM) including contour representation and object boundary description methods is presented. The focus of this paper is on the conducted works based on the external forces. These methods include edge-based and region-based methods. Furthermore, the explanations of these methods, as well as the advantages and disadvantages of each method are presented. Finally, a comparison between the performances of the conducted works has been done based on a database of Lung CT Scan Images. The present review helps readers identify research starting points in active contour models on COVID19 research, which is a high priority topic to guide researchers and practitioners. In addition, when there are not enough images to use machine learning techniques, such as deep learning methods, the experimental results indicate that active contour methods obtain promising results.
Nutrition Uptake and Disease of Children with Anemia in Peru, A Cross-Sectional Analysis
Authors: Westgard Christopher , Orrego-Ferreyros Luis A. , Calderón Liz Franco , Rogers Alexandra M. 
Published: July 2020

Abstract
Anemia is a multicausal problem affecting 41.7% of children under 5 worldwide. The prevalence of anemia in Peru has decreased only 6.8% from 2009 to 2017, despite great efforts made to distribute free multi-micronutrient supplements and promote the consumption of iron rich foods. The current study investigates the nutritional uptake and incidence of disease in children with anemia in Peru to better understand what is driving the high rates of anemia. METHODS A cross-sectional analysis of secondary data was conducted. Data from two national surveys were linked to evaluate the predictors of anemia. The associations were tested with Chi-square analysis and logistic multivariate regression analysis. RESULTS The sample included 586 children under 3. The prevalence of anemia was 53.2%, while 51.9% of the children consumed sufficient micronutrients to meet the daily recommended level for their age. Of those with anemia, 45.1% consumed sufficient micronutrients to meet the recommended level (p<0.001). The children with anemia were more likely to have an infectious or parasitic disease in the last year and less likely to have access to safe drinking water (p=0.057, p=0.002, respectfully). The logistic analysis displayed that having an infectious or parasitic disease increased the odds of having anemia (OR=1.6, p=0.043), and having access to safe drinking waters decreased the odds of having anemia (OR=0.58, p=0.044), while controlling for micronutrient uptake. CONCLUSIONS Nearly half of the children with anemia in Peru already consume sufficient nutrients to meet their daily requirement. However, they continue to have anemia, likely due to infectious diseases and parasites.