bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long noncoding RNAMeg3regulates myoblast plasticity and muscle regeneration through epithelial-mesenchymal transition
Authors: Dill Tiffany L. , Carroll Alina , Gao Jiachen , Naya Francisco J. 
Published: June 2020

AbstractFormation of skeletal muscle is among the most striking examples of cellular plasticity in animal tissue development, where mononucleated, lineage-restricted progenitor cells are reprogrammed by epithelial-mesenchymal transition (EMT) to produce multinucleated myofibers. While some mediators of EMT have been shown to function in muscle formation, the regulation of this process in this tissue remains poorly understood. The long noncoding RNA (lncRNA)Meg3is processed from the >200 kbDlk1-Dio3polycistron that we have previously shown is involved in skeletal muscle differentiation and regeneration. Here, we demonstrate thatMeg3regulates EMT in myoblast differentiation and skeletal muscle regeneration. Chronic inhibition ofMeg3in C2C12 myoblasts promoted aberrant EMT activation, and suppressed cell state transitions required for fusion and myogenic differentiation. Furthermore, adenoviralMeg3knockdown compromised muscle regeneration, which was accompanied by abnormal mesenchymal gene expression and interstitial cell proliferation in the regenerating milieu. Transcriptomic and pathway analyses ofMeg3-depleted C2C12 myoblasts and injured skeletal muscle revealed a significant dysregulation of EMT-related genes, and identified TGFβ as a key upstream regulator. Importantly, chemical inhibition of TGFβR1, as well as its downstream effectors ROCK1/2 and p38 MAPK, restored many aspects of myogenic differentiation inMeg3-depleted myoblastsin vitro. Thus,Meg3regulates myoblast identity to maintain proper cell state for progression into differentiation.Summary statementMuscle differentiation and regeneration are regulated by an evolutionarily conserved long noncoding RNA that restricts gene expression to coordinate cell state transitions
Enhancing Mask Activity in Dopaminergic Neurons Extends Lifespan in Flies
Authors: Tian Xiaolin 
Published: June 2020

AbstractDopaminergic neurons (DANs) are essential modulators for brain functions involving memory formation, reward processing, and decision making. Here I demonstrate a novel and important function of the DANs in regulating aging and longevity. Overexpressing the putative scaffolding protein Mask in two small groups of DANs in flies can significantly extend the lifespan in flies and sustain adult locomotor and fecundity at old ages. Such a Mask-induced beneficial effect requires dopaminergic transmission but cannot be recapitulated by elevating dopamine production in the DANs. Independent activation of Gαsin the same two groups of DANs via the drug-inducible DREADD system also extends fly lifespan, further indicating the connection of specific DANs to aging control. The Mask-induced lifespan extension appears to depend on the function of Mask to regulate microtubule (MT) stability. A structure-function analysis demonstrated that the ankyrin repeats domain in the Mask protein is both necessary for regulating MT stability (when expressed in muscles and motor neurons) and sufficient to prolong longevity (when expressed in the two groups of DANs). Furthermore, DAN-specific overexpression of Unc-104 or knockdown of p150Glued, two independent interventions previously shown to impact MTs dynamics, also extend lifespan in flies. Together these data demonstrated a novel DANs-dependent mechanism that, upon neuronal cell-type specific tuning of MT dynamics, modulates systemic aging and longevity in flies.
Linking Cerebellar Functional Gradients to Transdiagnostic Behavioral Dimensions of Psychopathology
Authors: Dong Debo , Guell Xavier , Genon Sarah , Wang Yulin , Chen Ji , Eickhoff Simon B. , Luo Cheng , Yao Dezhong 
Published: June 2020

AbstractHigh co-morbidity and substantial overlap across psychiatric disorders encourage a transition in psychiatry research from categorical to dimensional approaches that integrate neuroscience and psychopathology. Cerebellum is involved in a wide range of nonmotor cognitive functions and mental disorders. An important question thus centers on the extent to which cerebellar function can be linked to transdiagnostic dimensions of psychopathology. Here, this question is investigated using partial least squares to identify latent dimensions linking cerebellar connectome properties as assessed by macroscale spatial gradients of connectivity to a large set of clinical and behavioral measures in 198 participants across diagnostic categories. This analysis reveals significant correlated patterns of cerebellar connectivity gradients and behavioral measures that could be represented into four latent dimensions: general psychopathology, general lack of attention regulation, internalizing symptoms, and dysfunctional memory. Each dimension is associated with a distinct spatial pattern of cerebellar connectivity gradients. These findings highlight the relevance of cerebellar connectivity as a necessity for the study and classification of transdiagnostic dimensions of psychopathology.
Interspecies comparative metagenomics reveals correlated gut microbiome functional capacities among vertebrates
Authors: Gaulke Christopher A. , Armour Courtney R. , Humphreys Ian R. , Beaver Laura M. , Barton Carrie L. , Carbone Lucia , Ho Emily , Tanguay Robyn L. , Jiang Yuan , Sharpton Thomas 
Published: June 2020

AbstractWhile recent research reveals that the gut microbiome drives vertebrate health, little is known about whether the mechanisms these microbes employ to interact with physiology are consistent across host species. To help close this knowledge gap, we compared gut metagenomes across 10 vertebrate species, including biomedical animal models, to define the inter-species variation in the biochemical pathways encoded by gut microbiota. Doing so revealed gut-enriched pathways conserved across vertebrates, as well as pathways that vary concordantly with host evolutionary history. Overall, the functional capacity of the non-human gut microbiome generally reflects that of humans, though a subset of the pathways encoded by human gut microbiota are not well represented in non-human microbiomes. Collectively, these results support the use of animal models to study the mechanisms through which gut microbes impact human health, but suggest that researchers should cautiously consider which model will optimally represent a specific mechanism of interest.SignificanceEfforts to understand how the gut microbiome interacts with human physiology frequently relies on the use of animal models. However, it is generally not understood if the biochemical pathways encoded in gut microbiomes of these different animal models – which define the routes of interaction between gut microbes and their hosts – reflect those found in the human gut. To address this question, we compared gut metagenomes generated 10 different vertebrate lineages. In so doing, our study revealed that non-human gut metagenomes generally encode a set of pathways that are consistent with those found in the human gut. However, some human metagenome pathways are poorly represented in non-human guts, including pathways implicated in disease. Moreover, our analysis identified pathways that appear to be conserved across vertebrates, as well as pathways that are linked to the evolutionary history of their hosts, observations that hold potential to clarify the basis for phylosymbiosis.
Molecular underpinning of intracellular pH regulation on TMEM16F
Authors: Liang Pengfei , Yang Huanghe 
Published: June 2020

AbstractTMEM16F, a dual functional phospholipid scramblase and ion channel, is important in blood coagulation, skeleton development, HIV infection and cell fusion. Despite the advances in understanding its structure and activation mechanism, how TMEM16F is regulated by intracellular factors remains largely elusive. Here we report that TMEM16F lipid scrambling and ion channel activities are strongly influenced by intracellular pH (pHi). We find that low pHiattenuates whereas high pHipotentiates TMEM16F activation. Our biophysical characterizations pinpoint that the pHiregulatory effects on TMEM16F stem from protonation and deprotonation of the Ca2+binding sites, which in turn reduces and enhances Ca2+binding affinity, respectively. We further demonstrate that intracellular alkalization of 0.5 pHican significantly promote TMEM16F activities in a choriocarcinoma cell line. Our findings thus uncover a regulatory mechanism of TMEM16F by pHiand shine light on understanding the pathophysiological roles of TMEM16F in diseases with dysregulated pHiincluding cancer.
The factor structure of attention-deficit/hyperactivity disorder in schoolchildren
Authors: Arildskov Trine Wigh , Virring Anne , Lambek Rikke , Carlsen Anders Helles , Sonuga-Barke Edmund J.S. , Østergaard Søren D. , Thomsen Per Hove 
Published: June 2020

ABSTRACTThis study investigated the factor structure of attention-deficit/hyperactivity disorder (ADHD) by comparing the fit of a single-factor model, a correlated model with two or three factors, and a bifactor model with one general and two or three specific factors. Different three-factor solutions that varied with regard to the specification of the item “talks excessively” as impulsivity or hyperactivity were also tested. Parent ratings on the ADHD-Rating Scale (ADHD-RS-IV) were collected in a sample of 2044 schoolchildren (1st to 3rd grade) from the general population and in a clinical sample of 165 children and adolescents with ADHD referred to a public regional child and adolescent psychiatric hospital. Confirmatory factor analyses found a satisfactory fit for most models in both samples. However, a correlated three-factor model where “talks excessively” was included as an indicator of impulsivity and especially the bifactor version of this model with one general and three specific factors fit the data slightly better in the general population. In the clinical sample, a number of models performed equally well (the same version of the correlated three-factor model and all the bifactor models). Overall, the factor structure of ADHD seems to be better characterized by a bifactor model with a strong general factor and two or three weaker specific factors. Due to the strong general factor, we suggest emphasizing the ADHD-RS-IV total score rather than the subscale scores in clinical practice.
Lichtenberg optimization algorithm applied to crack tip identification in thin plate-like structures
Authors: Pereira João Luiz Junho , Chuman Matheus , Cunha Jr Sebastião Simões , Gomes Guilherme Ferreira 
Published: June 2020

Purpose
This study aims to develop a numerical identification and characterization of crack propagation through the use of a new optimization metaheuristics called Lichtenberg optimization.

Design/methodology/approach
The damage-identification problem is treated as an inverse problem, which combines finite element methods with intelligent computational methods to obtain the best possible response. To optimize the objectives, the Lichtenberg algorithm is applied, which includes concepts of random cluster growth in nature.

Findings
The simulations show that it is possible to determine the Lichtenberg spectrum algorithm a part of the structure to be removed and replaced in this case to stop the propagation.

Originality/value
The results show a very good crack identification in plates-like structures using the Lichtenberg algorithm (LA) based only in strain fields. Although many studies have reported on damage-identification-based optimization methods, very few have focused on the crack tip modeling and LA as the main solver.
Supply chain quality management performance measurement: systematic review
Authors: Karamouz Seyedeh Soudeh , Ahmadi Kahnali Reza , Ghafournia Mohamad 
Published: June 2020

PurposeThis study aims at investigating the existing knowledge in the literature on quality management performance measurement in order to identify performance measures in the field of total quality management and classify measures according to the three levels of supplier, customer and company.Design/methodology/approachA systematic literature review is conducted at the intersection of performance measurement and total quality management fields. Four databases including Web of Sciences, Scopus, Emerald and Google Scholar were searched up to 2018. A final sample of 24 articles was selected based on the inclusion/exclusion criteria that constitutes the knowledge base of the study.FindingsOne of the problems that many organizations face is the lack of knowledge and resources on how to evaluate, improve and manage the quality performance. Through analysis and synthesis of the literature, the study revealed the measures for assessing quality performance at three levels of supplier, customer and company.Research limitations/implicationsThis study focuses only on four databases, which may have limited the number of the databases included and thus the scope of this investigation to a certain extent.Originality/valueThe present study aimed to identify and classify different performance measures through a systematic literature review framework classifying these measures into three groups. The article brings together fragmented literature from multiple studies to categorize research output regarding performance measurement of supply chain quality. The paper shows the state of the performance measurement in total quality management in supply chain.
Managing the professional mobility of the Russian youth: specifics of scientific discourse and methodological landmarks
Authors: Mishschenko Dmitry N. , Vereshchagina Anna V. , Magomedov Magomed G. , Mareev Vladimir I. , Kumykov Ayes M. 
Published: June 2020

PurposeThe purpose of the paper is to determine the specifics of scientific discourse in the sphere of managing professional mobility of the Russian youth and to develop a cognitive scheme of sociological research of this problem.Design/methodology/approachThe authors use the potential of the stratification and activity approaches, the theory of multiplicity of professionalization, and multidimensional analysis as the most perspective method for sociological measuring of phenomena and processes in the professional sphere in the conditions of society's transformation.FindingsThe authors determine and study the key directions in the sphere of studying the professional mobility of the Russian youth and managing this process; substantiate the conceptual and methodological underdevelopment of this problem and offer the proprietary methodological strategy of its sociological study through distinguishing three stages of professional development of youth; substantiate the perspectives of its usage in studying the professional mobility of youth and constructing the effective policy of managing this process; outline the role of state and education in overcoming crisis factors of professional development of youth in the context of domination in the modern world and among the Russian youth.Research limitations/implicationsImportance of this research is predetermined by the need for theoretical consideration of top-priority directions in studying professional mobility of youth and the means of managing this process in view of the factors of crisis professionalization, unpreparedness of youth to adapt in spontaneous and quickly changing conditions of the labor market and absence of the conceptual sociological developments in this sphere.Originality/valueThe materials of the research and the offered cognitive scheme are aimed at formation of the methodological basis of studying the problem of managing the professional mobility of the Russian youth for the purpose of overcoming the crisis trajectory of professionalization of the Russian youth and increasing the effectiveness of its professional mobility in the conditions of increased mobility of the whole modern world.
How to use fuzzy screening system and data envelopment analysis for clustering sustainable suppliers? A case study in Iran
Authors: Izadikhah Mohammad , Farzipoor Saen Reza , Ahmadi Kourosh , Shamsi Mohadeseh 
Published: June 2020

PurposeThe aim of this paper is to classify suppliers into some clusters based on sustainability factors. However, there might be some unqualified suppliers and we should identify and remove those suppliers before clustering.Design/methodology/approachFirst, using fuzzy screening system, the authors identify and remove the unqualified suppliers. Then, the authors run their proposed clustering method. This paper proposes a data envelopment analysis (DEA) algorithm to cluster suppliers.FindingsThis paper presents a two-aspect DEA-based algorithm for clustering suppliers into clusters. The first aspect applied DEA to consider efficient frontiers and the second aspect applied DEA to consider inefficient frontiers. The authors examine their proposed clustering approach by a numerical example. The results confirmed that their method can cluster DMUs into clusters.Originality/valueThe main contributions of this paper are as follows: This paper develops a new clustering algorithm based on DEA models. This paper presents a new DEA model in inefficiency aspect. For the first time, the authors’ proposed algorithm uses fuzzy screening system and DEA to select suppliers. Our proposed method clusters suppliers of MPASR based on sustainability factors.
Cosmopolitanism, self-identity, online communities and green apparel perception
Authors: Khare Arpita , Kautish Pradeep 
Published: June 2020

PurposeThe research examined the influence of cosmopolitanism, global self-identity and online communities on Indian consumers’ green knowledge and consequently, its effect on the perception of green apparel product attributes.Design/methodology/approachA mall intercept technique was used for data collection in four cities in India. The hypothesized relationships were examined through structural equation modeling.FindingsCosmopolitanism, global self-identity and online communities influenced green knowledge. Green knowledge influenced Indian consumers’ perception of green apparel. The results indicate that social conformance and identification with online communities predicted consumers’ understanding of green apparel.Research limitations/implicationsThe research focused on green knowledge, cosmopolitanism, online communities and consumers’ perception of green apparel. The role of demographics, culture and product attributes like price, quality, promotions and design were not considered and may provide valuable insights.Practical implicationsGreen apparel manufacturers can communicate about the product attributes by linking it with growing global environmental consciousness, cosmopolitanism and global self-identity traits that focus on green consumption. Online communities can be used to inform, educate and promote green apparel.Social implicationThe study will pave the way forward to explore green consumption paradigms among fashion-oriented consumers in the Indian market who drive sustainable behavior.Originality/valueThe research suggested that conformance with global values and identification with online communities can be critical in helping consumers understand green apparel. It examined the importance of offline and online social conformance in evaluating green apparel.
Limit order books: a systematic review of literature
Authors: Tripathi Abhinava , Vipul Vipul , Dixit Alok 
Published: June 2020

Purpose
This study aims to provide a systematic literature review of the research study in the area of limit order book (LOB) mechanism of trading and its implications for market efficiency. The study attempts to document the recent theoretical developments and empirical findings from the literature exhaustively and identifies the research gaps for future research.

Design/methodology/approach
The study uses seven reputable databases to select 2,514 research studies spanning over 1981-2018 (finally compressed to a pool of 103 articles, based on relevance and impact). The study uses bibliometric network visualization and text analytics to categorize and examine the literature. The chosen articles are compiled and analyzed to provide a comprehensive account of the current research on LOBs.

Findings
The recent LOB literature is summarized on various criteria as follows: sub-areas, the types of economies and markets, methodologies and the LOB measures. The review identifies a dearth of studies on the LOBs in emerging markets. It suggests the potential research areas as intraday studies in emerging LOB markets; application of market indicators based on deeper levels of LOB, beyond the best prices; market fragmentation, order routing decision and its impact on order execution quality; optimal display of LOB levels; liquidity dynamics in quote-driven markets vis-à-vis LOB markets; effect of high-frequency trading on market microstructure; application of advanced techniques (e.g. machine learning models, zero-intelligent models); relationship between the trading speed, order aggressiveness, shape and resilience of the order book and informed trading; and information content of the auxiliary order submission strategies, including cancellation, amendments and hidden orders.

Originality/value
For the past 15 years, to the best of the knowledge, a comprehensive review of the literature on LOBs has not been published. The financial markets have transformed significantly over this period, driven by the adoption of LOBs, low latency trading and technological advancements in information dissemination. This article provides an extensive collection and classification of the literature on LOBs. This would be useful for the practitioners, future researchers and academics in the area of financial markets.
Reproductive characteristics that favor invasiveness inLeonotis nepetifolia(L.) R. Br.
Authors: Díaz‐Segura Omar , Golubov Jordan , Mandujano María C. , Zavala‐Hurtado José Alejandro 
Published: June 2020

AbstractReproductive systems are life attributes important in defining the demography and genetic constitution of invasive alien species populations. We describe the phenology, floral behavior and floral visitors in Mexican populations ofLeonotis nepetifoliaconsidered invasive in America, Asia and Oceania. The mating system was determined through pollination experiments and, with a morphological analysis of flowers (outcrossing index, OCI) and pollen/ovule ratio, the breeding system was evaluated. Germination of 1 and 2‐year‐old seeds was tested to assess the potential characteristics of germination.Leonotis nepetifoliawas reproductive for 7 months (June to December) and tended towards a specific season during autumn. Anthesis lasted 36 hr with protogyny and no hercogamy, with floral visitors of Apodiformes, Hymenoptera, Lepidoptera and Thysanoptera. Pollination experiments indicated a mixed mating system, whereas the OCI and the pollen/ovule ratio pointed towards a facultative xenogamous breeding system. Seed production was high (1,445 ± 132 seeds/plant); the seeds had potential longevity and were neutral photoblastic. One‐year‐old seeds germinated slightly later (= 2.6 ± 0.11 days) than 2‐year‐old seeds (= 1.9 ± 0.02 days), both synchronously (IS1yr= 0.88 ± 0.03 and IS2yr= 0.82 ± 0.02). Germination percentage for 1‐year‐old seeds was lower (55.33 ± 4.40%) than that of 2‐year‐old seeds (94.18 ± 0.59%), suggesting a potential longevity of the seeds in an optimal environment. Reproductive characteristics, such as wide reproductive period, mixed breeding system, copious seed production, seeds with potential longevity, and quick and synchronic germination in different light conditions, favor the invasive capacity ofLeonotis nepetifolia.