bluuebunny/crossref_metadata_2025_split huggingface dataset:
Composition-Sensitive Analysis of the Human Genome for Regulatory	Signals
Authors: Kel-Margoulis Olga V. , Tchekmenev Dmitri , Kel Alexander E. , Goessling Ellen , Hornischer Klaus , Lewicki-Potapov Birgit , Wingender Edgar 
Published: February 2025

Known transcription regulatory signals which generally act as transcription factor binding sites (TFs) differ significantly in their base composition. Therefore, their occurrence in a genome largely depends on the local base composition. In an attempt to initiate an all human genome analysis for the occurrence of potential TFs, we systematically analyzed the GC-content of distinct functional regions (e.g., upstream and downstream gene regions, exons, long and short introns, repetitive elements) and correlated the frequencies of potential binding sites of a representative set of TFs in these regions. For these analyses, we used the pattern collection of the TRANSFAC® database on transcriptional regulation, the information about functionally relevant combinations of them from the database TRANSCompel®, and our new resource, TRANSGenome™, which provides an overall annotation of the human genome with emphasis on its regulatory characteristics. We show that the occurrence of sequence patterns with regulatory potential may be supported by, but cannot be fully explained by either the GC content of a whole chromosome or its putative promoter regions, nor by the information content of the patterns. Several patterns, HNF-3, NFAT, and GC box, show a clear overrepresentation in all promoter groups as well as in all chromosomes. Other patterns, like E2F and CRE-BP1, are underrepresented in all promoter groups as well as in all chromosomes in comparison with random sequences. Simultaneously, both patterns are over-represented in promoters in comparison with repetitive elements. We define several structural characteristics of the proximal promoters that differentiate them from other functional genomic regions. Two well-known promoter elements, GC- and TATA-boxes, are statistically enriched in promoters in comparison with random sequences, repetitive elements and exons. Altogether, our findings provide insights into the macroheterogeneity amongst the individual chromosomes, into the microheterogeneity among different functional regions of individual chromosomes, contribute to further understanding of structural organization of gene regulatory regions, and give first hints on the development of regulatory features during evolution.
The Channel in Transporters is Formed by Residues That Are Rare in	Transmembrane Helices
Authors: Kalinina Olga V. , Makeev Vsevolod J. , Sutormin Roman A. , Gelfand Mikhail S. , Rakhmaninova Aleksandra B. 
Published: February 2025

Transmembrane transport is an essential component of the cell life. Many genes encoding known or putative transport proteins are found in bacterial genomes. In most cases their substrate specificity is not experimentally determined and only approximately predicted by comparative genomic analysis. Even less is known about the 3D structure of transporters. Nevertheless, the published experimental data demonstrate that channel-forming residues determine the substrate specificity of secondary transporters and analysis of these residues would provide better understanding of the transport mechanism. We developed a simple computational method for identification of channel-forming residues in transporter sequences. It is based on the analysis of amino acids frequencies in bacterial secondary transporters. We applied this method to a variety of transmembrane proteins with resolved 3D structure. The predictions are in sufficiently good agreement with the real protein structure.
iUDB: An Object-Oriented System for Modelling, Integration and	Analysis of Gene Controlled Metabolic Networks
Authors: Freier Andreas , Hofestädt Ralf , Lange Matthias 
Published: February 2025

The long-term objective of our work is the computational construction of complex cellular systems. Therefore, input data must be prepared systematically first. In the field of biological data information is spread out over hundreds of molecular databases. Different approaches of data integration have been already applied in the past to provide a homogeneous access to these databases. Actually, a system is required to store integrated data of different type locally and to search for networks found in the integrated dataset. Finally, the analysis of these networks can answer different questions, e.g. the role of biochemical substances in regulatory systems or the reasoning of metabolic diseases. In this article a novel object-oriented modelling approach in the field of biochemical networks is presented. Molecular objects are modelled conceptually using object classes, internally based on the object model OMG IDL. Specific object services are implemented automatically for each model and object instances are built using data integration. In combination with that, a specific view concept based on access paths has been implemented to model biochemical reaction rules automatically. Together with the application of graphical methods, pathways and cliques are computed by the system. They provide the topology of cellular process networks. The system has been implemented using Java and CORBA.
ON THE FEASIBILITY OF USING MODULAR SAFETY ISLANDS AS A TRAFFIC SAFETY TOOL
Authors: Osypov Valentyn 
Published: February 2025

The issue of using safety islands as an additional tool for influencing the level of accidents involving pedestrians has studied. A new type of modern security island - a modular island - is proposed, and the calculation of the maximum strength of the anchor fasteners of the arrangement is proposed. The proven fact is the effectiveness of the use of so-called "safety islands" on roads - an engineering device that allows pedestrians to safely cross the too wide carriageway of roads and technically narrow the traffic lane. Ensuring a high degree of protection of pedestrians stopped at the safety island from being by a vehicle remains an urgent issue. The search for a mathematical expression of the dependence of the holding capacity of the elements of the safety island on the strength factor of the material and the dimensions of the parts used is of interest from both a theoretical and a practical point of view. The presence of such a dependence would make it quite simple to determine the effect of changes in the cross-section of the fastening elements on the value of the energy intensity of the structures. Ensuring a high degree of protection of pedestrians stopped at the safety island from hit by vehicles remains an urgent issue. The search for a mathematical expression of the dependence of the holding capacity of the elements of the safety island on the strength factor of the material and the dimensions of the parts used is of interest from both a theoretical and a practical point of view. The main task in the search for mathematical dependencies was the modernization of already known structures and the determination of their maximum capabilities without changing the kinematics of the structure when interacting with road transport. In order to determine the possibility of increasing the holding capacity of the safety island fastening elements based on, it is necessary to consider different stages of the construction when cars hit them. The method of calculation proved that modular safety islands have a number of advantages compared to traditional ones, which will be fair if the necessary deterrent ability and strength factor of the material of the fastening elements ensured.
NATURAL TECHNOLOGIES OF PROVISION AND IMPROVEMENT INDOOR MICROCLIMATE PARAMETERS HEALTH CARE INSTITUTIONS
Authors: Predun Kostiantyn , Moisin Anatolii 
Published: February 2025

One of the main goals of the concept of sustainable development is to ensure a healthy lifestyle and well-being for everyone at any age. As a result of the implementation of the set tasks, the number of deaths and illnesses as a result of exposure to hazardous chemicals, pollution and poisoning of the environment should be significantly reduced by 2030. Engineering support systems create and maintain standardized values of air environment parameters in the premises of buildings and structures of various purposes. At present, in Ukraine, state standards are adapted to European requirements for indoor microclimate and technological solutions for its organization and provision. Currently, the most effective way of bacterial disinfection of indoor air is the use of ultraviolet light. The main disadvantage of this method of air purification from pathogenic microorganisms and viruses is the harmful effect on human health of possible excess radiation, excessive concentrations of ozone and mercury vapor - ingredients of the first class of danger, which are released during the processing. In addition, disinfection occurs exclusively in those places and areas where direct ultraviolet rays enter, and exclusively in the absence of people. To eliminate these shortcomings, an innovative technology of air purification in closed rooms is proposed, which is based on natural processes of disinfection of pathogenic microflora. The method is harmless to humans and pets. Design solutions of haloaerators - devices for air disinfection in closed rooms and the technology itself - have been developed and successfully tested. According to the results of the tests, their effectiveness was confirmed - the level of bacterial air pollution in a closed room decreased from the initial value of 1500 in 40 minutes of operation of the device to 10 CFU/m3.
ANALYSIS OF THE DEVELOPMENT OF LIDAR TECHNOLOGIES AND THE PROSPECTS OF THEIR USE DURING THE PERFORMANCE OF THE TASKS OF GEOSPATIAL SUPPORT OF ARMIES (FORCES) IN COMBAT CONDITIONS
Authors: Bulhakov Andrii , Bondar Svitlana , Demyanenko Roman , Medvedskyi Yurii , Kuzmych Oleksandr 
Published: February 2025

The results of the analysis of the implementation of geospatial support of troops (forces) by military units in the performance of assigned tasks in the course of repelling the large-scale aggression of the Russian Federation against Ukraine revealed serious gaps in the provision of geospatial data to troops (forces) [1]. In particular, given the unsatisfactory state of cartographic materials, remote methods of collecting, creating (updating) geospatial data are used. The use of Earth remote sensing materials with high resolution has become a priority. LiDAR systems (3D laser scanning) are one of the varieties of Earth remote sensing technology. However, in the Armed Forces of Ukraine, this technology in the field of geospatial support of troops (forces), especially in the conditions of hostilities, is rarely used. Therefore, the use of LiDAR systems in this field is relevant and requires a thorough analysis of the current state, prospects for development and application of this technology in the mentioned direction. In this regard, this article is aimed at identifying the prospects of using LiDAR systems to increase the efficiency of the tasks of creating and updating geospatial data in combat conditions. The article presents the results of the analysis of the use of LiDAR systems, reveals the advantages and disadvantages of this technology, discovers the prospects for its development and implementation in the Armed Forces of Ukraine, substantiated practical recommendations for its use in combat conditions. The materials of the article are of practical value for officials of military administrations engaged in planning and implementation of tasks of geospatial support of the Armed Forces of Ukraine during operations, developers and users of geospatial technologies in military affairs, as well as scientists investigating the issue of task transformation in the field of geospatial support of troops (forces).
THEMATIC GEOSPATIAL DATA SETS FOR GIS MONITORING OF URBAN LAND ENGINEERING AND CONSTRUCTION CONDITIONS
Authors: Kozar Valentyn , Michno Pavlo , Galchenko Nadiya , Klyuka Olena 
Published: February 2025

The lands of cities have specific features caused by the diversity of their intended use. The specifics of urban lands lead to the need to assess their condition from various aspects: socio-legal, urban planning, engineering and construction, environmental, and sanitary-hygienic. An analysis of publications devoted to the monitoring of urban lands indicates the relevance of forming datasets to evaluate the condition of the land based on these aspects, particularly from an engineering and construction perspective. Ukrainian regulations stipulate that the primary factors in the engineering and construction assessment of land are the engineering-geological conditions and the extent and development of hazardous geological processes and phenomena. Experience in urban planning shows that engineering and construction conditions can be defined as the properties and processes of the environment that influence decision-making regarding the construction and operation of structures. A generalization of approaches to the engineering and construction assessment of areas leads to the conclusion that the main criteria for this assessment are tectonic, geomorphological, engineering-geological, hydrogeological, hydrological, meteorological, and geodynamic indicators. Based on the analysis of the subject area, a class diagram of a thematic set of geospatial data for monitoring systems of the engineering and construction condition of urban lands has been proposed. The dataset includes information characterizing the suitability of the area for development. Fourteen classes were identified, reflecting the specific characteristics of the area regarding the placement of structures, their types and constructions, construction methods, and operation methods. The proposed diagram can be used in the creation of settlement monitoring systems to improve the justification of management decisions in planning area development.
Pengaruh Work Life Balance dan Beban Kerja terhadap Kinerja Pegawai Badan Kepegawaian dan Pengembangan Sumber Daya Manusia (BKPSDM) Kabupaten Karawang
Authors: Maulani Dinda Sopha , Marliani Sari , Yuliawati July 
Published: February 2025

Tujuan. Penelitian ini bertujuan untuk mengetahui pengaruh Work Life Balance dan Beban Kerja terhadap Kinerja Pegawai Badan Kepegawaian dan Pengembangan Sumber Daya Manusia (BKPSDM) Kabupaten Karawang.
Metode. Penelitian ini menggunakan metode kuantitatif deskriptif dan verifikatif. Pengambilan sampel menggunakan sampel jenuh, yaitu seluruh populasi sebanyak 53 pegawai dijadikan sampel. Pengumpulan data dilakukan melalui kuesioner. Analisis data menggunakan regresi linier bergandan dengan software SPSS.
Hasil. Hasil dari penelitian adalah work-life balance pegawai sangat baik, beban kerja pegawai tinggi, kinerja pegawai sangat baik, work-life balance berpengaruh positif secara parsial terhadap kinerja pegawai, beban kerja berpengaruh negatif secara parsial terhadap kinerja pegawai, dan work-life balance dan beban kerja berpengaruh positif secara simultan terhadap kinerja pegawai.
Implikasi. Pada penelitian selanjutnya dapat mengambil variabel lain yang dapat meningkatkan kinerja pegawai, antara lain motivasi kerja, budaya organisasi, disiplin kerja dan lain-lain, serta jumlah populasi dan sampel dalam penelitian perlu diperluas untuk memperoleh hasil yang lebih memuaskan.
Pengaruh Fitur Layanan, Privasi Keamanan dan Kepercayaan Terhadap Kepuasan Pengguna Aplikasi Dana Sebagai Alat Pembayaran (Studi Pada Mahasiswa Prodi Manajemen Unimed)
Authors: Saragih Sindy Aliffiyah , Siregar Zulkarnain 
Published: February 2025

Tujuan. Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh dari fitur layanan, privasi keamanan dan kepercayaan terhadap kepuasan pengguna aplikasi DANA sebagai alat pembayaran studi pada mahasiswa prodi manajemen UNIMED.
Metode. Penelitian ini menggunakan pendekatan kuantitatif. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik pendekatan porposive sampling dengan jumlah sampel sebanyak 100 responden menggunakan metode analisis data partial last square yang didukung oleh SmartPLS vers 4.0 bersama dengan pendekatan Model Structural Equation (SEM).
Hasil. Hasil dari penelitian ini menyatakan bahwa: 1) fitur layanan tidak berpengaruh secara signifikan terhadap kepuasan pengguna, 2) privasi keamanan tidak berpengaruh secara signifikan terhadap kepuasan pengguna, 3) kepercayaan berpengaruh secara signifikan terhadap kepuasan pengguna, 4) kepercayaan mampu memediasi fitur layanan terhadap kepuasan secara signifikan, 5) kepercayaan mampu memediasi privasi kepercayaan terhadap kepuasan pengguna.
Implikasi. Perusahaan aplikasi perlu meningkatkan fitur layanan dan privasi keamanan untuk memastikan kepuasan dan keamanan pengguna. Selain itu, penting untuk tetap mempertahankan dan meningkatkan kepercayaan pengguna dengan terus memenuhi harapan mereka, sehingga reputasi baik perusahaan terjaga.
A biztosítási intézkedés szerepe az adóvégrehajtási eljárásban
Authors: Erdős Éva , Móricz Alíz 
Published: February 2025

A végrehajtási jog rendszerében a biztosítási intézkedés az, amely előzetesen igénybe vehető jogintézményként a jogosult érdekeit (és a követelés kielégítését) helyezi törvényi védelem alá, ezáltal hozzájárulva a végrehajtási eljárás eredményes lefolytatásához. Ez a megállapítás kiváltképp érvényesül az adóvégrehajtási eljárásban, ahol gyakran előfordul, hogy végrehajtási kényszercselekmény alkalmazása nélkül számottevő nehézséggel járna az adótartozás adós általi teljesítésének előmozdítása, így a biztosítási intézkedés adóvégrehajtásban történő elrendelése könnyen szükségessé és nélkülözhetetlenné válhat.
Az ügyelet és a készenlét munkajogi integrációja az egészségügyi munkaidő-szervezés folyamatába
Authors: Jakab Nóra , Pap Zoltán 
Published: February 2025

A munkaidő és annak beosztása, szervezése a felek közötti munkaviszony alapvető tartalmi eleme, nem kötelező, de egy természetes eleme. Mind a nemzetközi, mind az európai uniós szabályozás egyik kardinális pontja. Úgy véljük, hogy legalább annyira versenytényező, mint amennyire munkavédelmi kérdés, a tágabb értelemben vett „munkakörnyezet” része. A munkaidő-szabályozással foglalkozni nagy kihívás, különösen, ha ezt az egészségügy területén tesszük. Az ágazat meghatározó munkajogi környezete 2020 őszén radikális reformon ment keresztül. A jogviszonyváltás során a közalkalmazotti státuszból egy egészen speciális szolgálati törvény hatálya alá kerültek az egészségügyi dolgozók. Az ebből következő változások az általános értelmezési kérdéseken belül – a munkaidő megszervezésének speciális nehézségeit, illetve az ezzel koherens javadalmazási problémákat is felszínre hozták, egyre komolyabb visszhangot generálva a hazai nyilvánosságban is.
Effect of different types of mulches on growth and yield of turmeric
Authors: Haque M M , Begum S , Rahman M S , Alam A B M S , Zhuma M A A , Manik M M H 
Published: February 2025

The experiment was conducted at the Bangladesh Institute of Nuclear Agriculture (BINA) sub-station Khagrachari during 2020-2021 to compare the effect of different mulches on the growth and yield of Binahalud-1. Experiment was conducted with different organic mulches vizs., bamboo leaf, paddy straw, water hyacinths, and silver color plastic. A treatment without mulching was also kept as a control. The experiment was laid out in a randomized block design with three replications. The results indicated that the plants mulched with bamboo leaves recorded maximum average plant height of 150 cm, number of leaves 71.333, number of tillers 11, leaf length and leaf width 80 cm, 16.66 cm, leaf weight 29.33 gm, petiole length 40 cm and petiole weight 17.33 gm as compared to other mulches. In case of the yield of turmeric, the bamboo leaf mulch gave maximum fresh rhizome yield of 33.2 t ha-1 . From this study it is revealed that among the treatments bamboo leaf is the best mulch material for turmeric production.
Bangladesh J. Nuclear Agric, 38(2): 161-167, 2024
Perhitungan Stabilitas Dinding Penahan Tanah (Studi Kasus: Proyek Pembangunan Gedung Kantor Walikota Kendari)
Authors: Jaya Hasran , Sulha Sulha , Minmahddun Anafi , Adityawan Muh Handy Dwi , Mursidi Baso , Sriyani Rini , Masiki Sultan Machmud Hasan 
Published: February 2025

Abstrak
Proyek Pembangunan Gedung Kantor Walikota Kendari adalah proyek yang dibangun Diatas lahan seluas 6,3 hektar dan menelan anggaran sebesar 250 milyar rupiah yang bersumber dari Anggaran Pendapatan Belanja Daerah (APBD) Kota Kendari. Pembangunan Gedung Kantor Walikota Kendari ini terdiri dari tiga bangunan utama, yaitu gedung podium setinggi lima lantai, tower setinggi sembilan lantai dan gedung parkir setinggi tuga lantai dan akan dikerjakan secara bertahap selama tiga tahun. Karena pada proyek Pembangunan Gedung Kantor Walikota Kendari memiliki bangunan basement parkir yang berada dibawah elevasi tanah yang menggunakan struktur dinding penahan tanah, maka dibutuhkan perhitungan yang akurat untuk menahan gaya yang dapat menyebabkan kegagalan struktur dinding penahan tanah sebagai dinding basement parkir pada proyek pembangunan gedung kantor walikota kendari. Supaya dapat menahan tanah yang memilki kondisi khusus tersebut, konstruksi ini harus mampu memberikan kestabilan terhadap pengaruh gaya-gaya eksternal maupun internal. Oleh karena itu, dalam perencanaan dinding penahan tanah, kestabilan konstruksi harus ditinjau terhadap pengaruh gaya-gaya eksternal yang dapat menyebabkan keruntuhan guling (overtuning failure), keruntuhan geser (sliding failure), dan keruntuhan daya dukung tanah (bearing capacity failure), maupun terhadap gaya-gaya internal yang dapat pecahnya konstruksi.
Peran Teknologi Informasi Dan Mekanisme Collaborative Governance Mendukung Penyelenggaraan Transportasi Berkelanjutan Di Provinsi Sulawesi Tenggara
Authors: Satyadharma Maudhy , Mokui Hasmina Tari , Adris Ade Putra  , Laode Muhammad Golok Jaya  , Abdul Kadir  , Arsyad La Ode Muhammad Nurrakhmad 
Published: February 2025

Penelitian ini ingin mengkaji dan menganalisis mengenai peran Teknologi Informasi dan Mekanisme Collaborative Governance dalam mendukung penyelenggaraan Transportasi Berkelanjutan di Provinsi Sulawesi Tenggara. Penelitian ini menerapkan metode kualitatif dimana informan dipilih secara purposive yaitu menggunakan pertimbangan bahwa mereka memahami permasalahan dalam penyelenggaraan transportasi darat di wilayah Provinsi Sulawesi Tenggara. Hasil penelitian menyimpulkan bahwa peran dari Teknologi Informasi terhadap Kebijakan Transportasi berkelanjutan yaitu melakukan pengumpulan data, monitoring dan pengolahan data lebih mudah, efisien dan efektif serta mendorong pengambilan keputusan lebih akurat. Sedangkan peran dari mekanisme Collaborative Governance terhadap Kebijakan Transportasi berkelanjutan yaitu mendorong keterlibatan berbagai pihak, mendorong pengambilan keputusan yang lebih baik karena masukan berbagai pihak serta mendorong keputusan yang lebih fleksibel dan responsivitas terhadap perubahan kondisi dan kebutuhan masyarakat.