bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Genetic Regulation of size Variation in the Transcriptome of the Cerebrum in the Chicken and its role in domestication and brain size evolution
Authors: Höglund Andrey , Strempfl katharina , Fogelholm Jesper , Wright Dominic , Henriksen Rie 
Published: April 2020

Abstract
Background: Large difference in cerebrum size exist between avian species and populations of the same species and is believed to reflect differences in processing power. During domestication chickens developed a larger cerebrum compared to their wild progeny, the Red Jungle fowl. The underlying mechanisms that control cerebrum size and the extent to which genetic regulation is similar across brain regions is not well understood. In this study, we combine measurement of cerebrum size with genome-wide genetical genomics analysis to identify the genetic architecture of the cerebrum, as well as compare the regulation of gene expression in this brain region with gene-expression in other regions of the brain (the hypothalamus) and somatic tissue (liver). Results: We identify one candidate gene that putatively regulates cerebrum size ( MTF2 ) as well as identified a large number of eQTL that regulate the transcriptome in cerebrum tissue, with the majority of these eQTL being trans-acting. The overall regulation of gene expression variation in the cerebrum was markedly different to the hypothalamus, with relatively few eQTL in common. In comparison, the cerebrum tissue shared more eQTL with a distant tissue (liver) than with a neighboring tissue (hypothalamus). Conclusion: The candidate gene for cerebrum size ( MTF2 ) has previously been linked to brain development making it a good candidate for further investigation as a regulator of inter-population variation in cerebrum size. The lack of shared eQTL between the two brain regions implies that genetic regulation of gene expression appears to be relatively independent between the two brain regions and suggest that co-evolution between these two brain regions might be more functionally driven than developmental. These findings have relevance for current brain size evolution theories.
A novel cucumber albino mutant caused by chloroplast development deficiency
Authors: Yan Jinqiang , Liu Bin , Cao Zhenqiang , Sun Piaoyun , Liu Wenrui , Liang Zhaojun , Wang Min , Peng Qingwu , Chen Lin , Lin Yu’e , Jiang Biao , He Xiaoming 
Published: April 2020

Abstract
Background Photosynthesis is a fundamental process for plant growth and development dependent on a precise network, including formation of chloroplast and chlorophyll synthesis. Chloroplast development deficiency could lead to albinism in higher plant. Results Here, we report a cucumber albino recessive mutant that processed white cotyledons under light condition and is unable to produce first true leaf. Meanwhile, albino mutant could grow out creamy green cotyledons under dark condition but died after exposing to light. Using fluorescence microscopy and transmission electron microscope (TEM), impaired chloroplasts were observed. We identified 7 and 3 differentially expressed genes (DEG) involved in Chlorophyll metabolism and Methylerythritol 4-phosphate (MEP) pathway through transcriptome analysis, respectively. We also examined the reported homologous genes for albino mutants from other plants. Two of 12 genes, TOC159 and DXS1, were up-regulated in cucumber albino mutants as well. The reliability of RNA sequencing results were further confirmed by real-time quantitative PCR (qPCR). Conclusions Taken together, we elaborate the differences between albino mutant and normal seedlings from a single cucumber progeny. This mutant is a new material to study protoplast development.
Children, media and food. Food advertising aimed at children audience in Spanish TV.
Authors: Jimenez-Marin gloria_jimenez , Garcia Jesus Delgado , Medina Irene Garcia 
Published: April 2020

Abstract
Healthy lifestyle habits provide the basis for optimal development in minors and advertising can affect, positively or negatively, the maintenance of certain of these habits. Even more, the advertising directly related to food. Therefore, this text aims to assess the levels of compliance with the Code of Advertising for Food and Beverages Directed to Minor Children (PAOS Code) during 2018. Analyzing the advertising of food and beverages aimed at children during the protection strip reinforced is evidence of the growing problem of obesity in the child population generated through the food industry. This investigation analyzed a sample obtained through the recording, for 7 days, of the content of commercial breaks in the television broadcast of specialized and generalist channels in Spain with higher audience rates. In this regard, the data reveal a systematic breach of this code that persuades the vulnerable conscience of infants through a business fabric that far from promoting healthy living habits cause malnutrition in society.
Susceptibility of An. gambiae s.l. from Côte d’Ivoire to Insecticides used on Insecticide-Treated Nets: Evaluating the Additional Entomological Impact of Piperonyl Butoxide and Chlorfenapyr
Authors: Kouassi Bernard L. , Edi Constant , Tia Emmanuel , Konan Lucien Y. , Akré Maurice A. , Koffi Alphonsine A. , Ouattara Allassane F. , Mea Antoine Tanoh , Zinzindohoue Pascal , Kouadio Blaise , Andre McKenzie , Irish Seth R. , Armistead Jennifer , Dengela Dereje , Cissé Ndombour G. , Flatley Cecilia , Chabi Joseph 
Published: April 2020

Abstract
Background : Pyrethroid-treated mosquito nets are currently the mainstay of vector control in Côte d’Ivoire. However, resistance to pyrethroids has been reported across the country, limiting options for insecticide resistance management due to the paucity of alternative insecticides. Two types of insecticide-treated nets (ITNs), ITNs with pyrethroids and the synergist piperonyl butoxide (PBO), and Interceptor ® G2 nets, a net treated with a combination of chlorfenapyr and alpha-cypermethrin, are believed to help in the control of pyrethroid-resistant mosquitoes. Methods : The susceptibility of An. gambiae s.l. to pyrethroid insecticides with and without pre-exposure to PBO as well as to chlorfenapyr was investigated in fifteen sites across the country. Susceptibility tests were conducted on 2- to 4-day old adult female An. gambiae s.l. reared from larval collections. The resistance status, intensity, and effects of PBO on mortality after exposure to different concentrations of deltamethrin, permethrin and alpha-cypermethrin were determined using WHO susceptibility test kits. In the absence of a WHO-recommended standard protocol for chlorfenapyr, two interim doses (100 and 200 µg/bottle) were used to test the susceptibility of mosquitoes using the CDC bottle assay method. Results : Pre-exposure to PBO did not result in full restoration of susceptibility to any of the three pyrethroids for the An. gambiae s.l. populations from any of the sites surveyed. However, PBO pre-exposure did increase mortality for all three pyrethroids, particularly deltamethrin (from 4.4% to 48.9%). Anopheles gambiae s.l. from only one site (Bettie) were susceptible to chlorfenapyr at the dose of 100 µg active ingredient (a.i.)/bottle. Even at the dose of 200 µg (a.i.)/bottle, susceptibility was only recorded in 10 of the 15 sites.Conclusion : Low mosquito mortality was found for pyrethroids alone, and while PBO increased mortality, it did not restore full susceptibility. The vector was not fully susceptible to chlorfenapyr in one third of the sites tested. However, vector susceptibility to chlorfenapyr seems to be considerably higher than for pyrethroids alone or with PBO. These data should be used cautiously when making ITN procurement decisions, noting that bioassays are conducted in controlled conditions and may not fully represent field efficacy.
Incidence and risk factors of residual bile duct stones after extraction by endoscopic retrograde cholangiopancreatography
Authors: Fujita Akashi , Nakahara Kazunari , Michikawa Yosuke , Morita Ryo , Suetani Keigo , Sato Junya , Igarashi Yosuke , Ikeda Hiroki , Matsunaga Kotaro , Watanabe Tsunamasa , Itoh Fumio 
Published: April 2020

Abstract
Background: Residual bile duct stones may be found eventually after confirmation of complete stone removal. Aims: we retrospectively investigated the incidence and risk factors of residual bile duct stones after extraction by endoscopic retrograde cholangiopancreatography (ERCP). Methods: We conducted a retrospective review of all ERCP sessions that underwent endoscopic bile duct stone extraction between April 2014 and March 2019. A total of 505 patients were enrolled to evaluate the incidence and risk factors of residual bile duct stones after ERCP. Results: The rate of residual stones was 4.8% (24/505). Residual stones were detected by CT (12/24) or MRCP (12/24). In univariate analyses, a large number of stones (P = 0.01), long procedure time (P = 0.005), and performance of the pancreatic duct guidewire placement method (P-GW) for selective bile duct cannulation (P = 0.01) were the factors involved in residual stones. In multiple logistic regression analysis, performing P-GW was retained as the only independent factor of residual stones (odds ratio [OR], 3.4; 95% CI, 1.1–9.5; P = 0.02). Conclusions: When removing bile duct stones with a pancreatic guidewire in place, paying attention to residual stones is necessary.
Impact assessment of climate change on hydro-climatic conditions of arid and semi-arid watersheds (case study: Zoshk-Abardeh watershed, Iran)
Authors: Rahimpour Mohadese , Tajbakhsh Mohamad , Memarian Hadi , Aghakhani Afshar Amirhosein 
Published: April 2020

Abstract
The hydrologic cycle in the river basins of semi-arid regions is severely influenced by climate change. The aim of this study is to assess the impact of climate change on the hydro-climatic condition in Zoshk-Abardeh watershed in eastern Iran. The Soil and Water Assessment Tool (SWAT) was calibrated using the Sequential Uncertainty Fitting – Version 2 (SUFI-2) algorithm to improve the simulation results of the runoff. The Model for Interdisciplinary Research on Climate-Earth System Models (MIROC-ESM) was used to investigate the effects of climate change on hydro-climatic components under the representative concentration pathway scenarios (RCPs: 2.6, 4.5, 6.0, and 8.5) and in near- (2014–2042), mid- (2042–2071), and far- (2072–2100) futures. The temperature component under the RCP4.5 and RCP6.0 during the near- and mid-future intervals and the far-future period (for RCP6.0) indicated a significant rising trend. The rainfall parameter in all RCPs and future intervals showed an insignificant descending trend. Runoff alterations under the RCP4.5 amid the mid- to far-future intervals and under the RCP8.5 throughout the far-future period trailed a significant descending trend. The results determined that the temperature will track an upward tendency, while precipitation and runoff will follow a descending trend in this watershed by the end of the 21st century.
An Operationally Simple and Efficient Synthesis of 7-Benzylidene-substitutedphenyl- 3,3a,4,5,6,7-hexahydro-2H-indazole by Grinding Method
Authors: Raut Santosh , Dhotre Bharat , Tidke Atul , Pathan Mohammad Arif 
Published: April 2020

Background:
An eco-friendly, operationally simple and efficient reaction is shown between various
2,6-bis-(substituted-benzylidene)-cyclohexanones and differently substituted hydrazine in the presence of acetic
acid.

Methods:
The reaction between various 2,6-bis-(substituted-benzylidene)-cyclohexanones and differently
substituted hydrazine in the presence of acetic acid afforded 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7-
hexahydro-2H-indazole in 74 to 92 % yield in short reaction time using the grindstone technique.

Results and Discussion:
The notable advantages of this method include mild synthetic conditions, weak acid
catalysis, and non-hazardous solvent which make this method environmentally safer.

Conclusion:
In conclusion, we have developed an efficient, simple and eco-friendly method for the synthesis of
7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7-hexahydro-2H-indazole by grinding technique. The notable
benefits of this method are waste minimization, no organic solvent required, simple procedure, easy work-up,
and clean reaction profile.
The Development of Customer Loyalty Model for Mobile Travel Agent Application
Authors: Prihartono Budhi , Ashari Muhammad Azhar , Rizkiana Aldila 
Published: April 2020

The growth of smartphone users in Indonesia opens up business opportunities for service providers, particularly via m-commerce. However, along with these great opportunities and rivalry, service providers are required to make consumers faithful to the products and services they deliver. This research aims to develop a conceptual model for an application based on m-commerce, particularly mobile travel agent applications. The research model is based on applying five dimensions of Mobile Service Quality (M-S-QUAL), customer engagement, and commitment as the predecessor factors of customer loyalty. The study was conducted on 760 MTA application users who participated in an online survey. The data were divided into two groups based on income level to be further analyzed using the Multigroup Structural Equation Modeling (SEM). The Multigroup SEM analysis shows that the concept of customer loyalty was explained differently by the two groups with different income levels.
Moving into the neighbourhood: embodiment, sacrament and ritual in urban mission
Authors: Bucke Hannah 
Published: April 2020

Abstract
This article aims to explore the significance of embodiment, sacrament and ritual in urban pioneer ministry. Stemming from early experiences working within this context and from a particular experience of using installation art to help engage those outside the Church with its rituals and stories, I argue for the importance of the embodied experience within a particular place as a means of engagement. The literature surveyed makes the case for a broad understanding of the sacramental in which all material things have sacramental potential. The differing influences of theology and social anthropology upon the literature offer distinct perspectives on the drawing of boundaries in relation to sacrament and ritual, and on how meaning is made from experience in the light of prior knowledge and understanding of the Christian tradition.
The temptations of politics: Jesus’ temptation and ours in John Milton’s Paradise Regained
Authors: Plant Stephen J. 
Published: April 2020

Abstract
This paper aims to shed light on the ways in which politics can be a site of temptation for Christians. In the first part, it explores the circumstances in which John Milton wrote Paradise Regained, printed in 1671. The poem may be understood, in part, as Milton’s reflection on the failed politics of the Republic in which he had played a leading role as a civil servant and one of the Republic’s chief propagandists. The second part of the argument offers a reading of Milton’s poetic account of the story of Jesus’ 40 days in the wilderness, which interprets Jesus’ temptations politically as a series of attempts by Satan to deflect Jesus’ messianic identity, revealed at his Baptism, from its true course.
Computational Homogenization of Cement-Based Porous Piezoelectric Composites with Random Structure
Authors: Pavol Novák , Peter Bishay , Milan Žmindák 
Published: April 2020

Abstract
The finite element method (FEM) is used to characterize the effective thermo-electromechanical material properties of cement-based piezoelectric ceramic composites in this paper. The micromechanics representative volume element (RVE) approach is used with distribution of piezoelectric particles in the porous cement matrix. The effects of the piezoelectric particle volume fraction and pore volume fraction on the effective composite properties are determined using sets of different boundary conditions. Microscale homogenization is carried out through the analysis of particles which are randomly distributed in a homogenized matrix.
Glaucoma vs. Biomechanical Properties of Cornea
Authors: Branislav Hučko , Lea Ferková Sylvia , Stanislav Ďuriš , Jan Rybář , Peter Pavlásek 
Published: April 2020

Abstract
The paper deals with the influence of various biomechanical parameters on the intraocular pressure (IOP). The IOP is a very important factor in more accurate diagnosis and better management of glaucoma. To get a more realistic value of IOP the measurement methodology must reflect the patient’s individual biometric and biomechanical parameters, for example age, sex, race, biomechanical properties of cornea, etc. Many measuring methods are based on the applanation of cornea during its loading by the measuring device - tonometers. These tonometers apply the Imbert – Fick law [1], which determines their size. This work also addresses the current approaches to creating more realistic IOP data.
Comparison of Detailed Belt - Cylinder Interaction Model with Classical Belt Friction Formula
Authors: Bulín Radek , Hajžman Michal 
Published: April 2020

Abstract
This paper deals with a comparison of the classical belt friction formula, also called Euler-Eytelwein equation, with a detailed belt-cylinder interaction model. The belt friction is a typical pedagogical problem where the usage of equilibrium conditions is shown, but also have a practical usage, e.g. a heavy ship anchor pulling or a belt brake. The presented belt-cylinder interaction model is based on the absolute nodal coordinate formulation of beam finite elements with the consideration of nonlinear contact forces between a beam and a rigid cylinder.
Influence of Fiber Deposition and Orientation on Stress Distribution in Specimens Produced Using 3D Printing
Authors: Majko Jaroslav , Handrik Marián , Vaško Milan , Sága Milan 
Published: April 2020

Abstract
Continuous fiber fabrication technology, developed by Markforged and used in MarkTwo printers, allows using of reinforcing fibers, which improve mechanical properties of produced parts. The technology enables choosing of two fiber deposition strategies: isotropic fiber fill and concentric fiber fill. With the isotropic fiber fill, there is an option to set up various fiber angles in each layer. The article is focused on stress distribution analysis using FEM in a matrix and individual reinforcing fibers of specimens loaded to uniaxial tension. Main observed parameters are stresses in matrix and fiber and usage of the reinforcing material.
Ureteric injuries associated with hysterectomy: A five-year experience in treating seventeen ureteric units in nine patients
Authors: Iduh Ogwuche Edwin , Onwukwe John , S. Hembah-Hilekaan 
Published: April 2020

Objective:
Ureteric injuries following pelvic surgeries have been widely reported. It often causes severe morbidity and even mortality. It is generally agreed that the true incidence is difficult to determine as only patients who become symptomatic may present for intervention. The aim of this article was to document our 5-year experience in managing patients with post-hysterectomy ureteric injury.

Materials and Methods:
A retrospective review of all patients with ureteric injuries following hysterectomy managed at public and private hospitals between 2008 and 2013 was undertaken.

Results:
Seventeen injuries occurred in nine patients within the study period; eight patients sustained bilateral injuries. Ureteric ligation and transections were the most common. The left ureter was more commonly injured (58.8%) than the right. Ureteroneocystostomy was the most common method for treating injuries in the distal 2.5 cm of the ureter in this study. A mortality rate of 33.3% was recorded while all the other six patients had a favorable outcome.

Conclusion:
Early recognition and treatment guarantee a good outcome in the management of ureteric injuries.
Time to Catheter Angiography for Gastrointestinal Bleeding after Prior Positive Investigation Does Not Affect Bleed Identification
Authors: Brahmbhatt Akshaar , Rao Pranay , Cantos Andrew , Butani Devang 
Published: April 2020

Objective:
To determine, time to angiography for patients with positive gastrointestinal bleeding (GIB) on prior investigation (endoscopy [ES], nuclear medicine [NM] Tc99m red blood cells (RBC) scan, or computed tomography angiography), affects angiographic bleed identification.

Materials and Methods:
Visceral Angiograms performed from January 2012 to August 2017 were evaluated. Initial angiograms performed for GIB were included in the study. Exclusion criteria included recent abdominal surgery or procedure (30 days), empiric embolization (embolization without visualized active bleeding), and use of vasodilators, or subsequent angiogram. Timing and results of ES, NM Tc99m RBC scan, or computed tomography angiogram and catheter angiogram were recorded. In addition, age, gender, angiogram time, anti- platelet therapy, anti-coagulation therapy, bleed location, international normalized ratio, and units of packed RBCs received in the 24 h before catheter angiography were included in the study.

Results:
One hundred and seventy angiograms were included in the final analysis. Forty-three angiograms resulted in the identification of an active bleed (68.9 years, and 67.4% male). All of these patients were embolized successfully. One hundred and twenty-seven angiograms failed to identify an active bleed (70.4 years, and 49.6% male). No significance was found across the two groups with respect to time from prior positive investigation. Receiver operating characteristic analysis demonstrated that units of packed RBCs received in the preceding 24 h were correlated with positive bleed identification on catheter angiography.

Conclusion:
Time to angiography from prior positive investigation, including ES, NM Tc99m RBC scan, or computed tomography angiogram does not correlate with positive angiographic outcomes. Increasing units of packed RBCs administered in the 24 h before angiogram do correlate with positive angiographic findings.
Conformations and Three-Dimensional Structures of Selected SARS-CoV-2 Drug Candidates
Authors: Kirschner Karl , Heiden Wolfgang 
Published: April 2020

Quantum mechanical theories are used to search and optimized the conformations of proposed small molecule candidates for treatment of SARS-CoV-2. These candidate compounds are taken from what is reported in the news and in other pre-peer-reviewed literature (e.g. ChemRxiv, bioRxiv). The goal herein is to provided predicted structures and relative conformational stabilities for selected drug and ligand candidates, in the hopes that other research groups can make use of them for developing a treatment.Initial exploration for conformations are performed at the HF/6-31G(d)//HF/6-31G(d) theory level, which are then further optimized at more rigorous theory levels (e.g. B97-D3BJ/cc-pVTZ//B97-D3BJ/cc-pVTZ). The resulting structures are made available via GitHub.