bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sand fly fauna of Crete and the description of Phlebotomus (Adlerius) creticus n. sp. (Diptera: Psychodidae)
Authors: Dvořák Vít , Tsirigotakis Nikolaos , Pavlou Christoforos , Dokianakis Emmanouil , Akhoundi Mohammad , Halada Petr , Volf Petr , Depaquit Jérôme , Antoniou Maria 
Published: November 2020

Abstract
Background
The Greek island of Crete is endemic for both visceral leishmaniasis (VL) and recently increasing cutaneous leishmaniasis (CL). This study summarizes published data on the sand fly fauna of Crete, the results of new sand fly samplings and the description of a new sand fly species.

Methods
All published and recent samplings were carried out using CDC light traps, sticky traps or mouth aspirators. The specific status of Phlebotomus (Adlerius) creticus n. sp., was assessed by morphological analysis, cytochrome b (cytb) sequencing and MALDI-TOF protein profiling.

Results
Published data revealed the presence of 10 Phlebotomus spp. and 2 Sergentomyia spp. During presented field work, 608 specimens of 8 species of Phlebotomus and one species of Sergentomyia were collected. Both published data and present samplings revealed that the two most common and abundant species were Phlebotomus neglectus, a proven vector of Leishmania infantum causing VL, and Ph. similis, a suspected vector of L. tropica causing CL. In addition, the field surveys revealed the presence of a new species, Ph. (Adlerius) creticus n. sp.

Conclusions
The identification of the newly described species is based on both molecular and morphological criteria, showing distinct characters of the male genitalia that differentiate it from related species of the subgenus Adlerius as well as species-specific sequence of cytb and protein spectra generated by MALDI-TOF mass spectrometry.
Effect of body mass index on serum urate and renal uric acid handling responses to an oral inosine load: experimental intervention study in healthy volunteers
Authors: Dalbeth Nicola , Allan Jordyn , Gamble Gregory D. , Horne Anne , Woodward Owen M. , Stamp Lisa K. , Merriman Tony R. 
Published: November 2020

Abstract

Background
High body mass index (BMI) is strongly associated with hyperuricaemia. It is unknown whether overweight and obesity influences serum urate primarily through increased urate production or reduced renal clearance of uric acid. The aim of this study was to determine the influence of BMI on the response to inosine, a purine nucleoside that functions as an intermediate in the purine salvage and degradation pathways.

Methods
Following an overnight fast, 100 healthy participants without gout attended a study visit. Blood and urine samples were taken prior to and over 180 min after 1.5 g oral inosine. Serum urate and fractional excretion of uric acid (FEUA) were analysed according to high BMI (≥ 25 kg/m2) and low/normal BMI (< 25 kg/m2) groups, and according to BMI as a continuous variable.

Results
Participants in the high BMI group (n = 52, mean BMI 30.8 kg/m2) had higher serum urate concentrations at baseline (P = 0.002) compared to those with low/normal BMI (mean BMI 21.8 kg/m2). However, the high BMI group had a smaller increase in serum urate following the inosine load (P = 0.0012). The two BMI groups had a similar FEUA at baseline (P = 0.995), but those in the high BMI group had a smaller increase in FEUA following the inosine (P = 0.0003). Similar findings were observed when analysing BMI as a continuous variable. Those with high BMI had a smaller increase in FEUA per increase in serum urate, compared to those with low BMI (P = 0.005).

Conclusions
In a fasting state, people with high BMI have elevated serum urate levels but similar FEUA values compared with those with low/normal BMI. Following a purine load, those with high BMI have an attenuated renal excretion of uric acid. These data, using an experimental method to dynamically assess human urate handling, suggest that people with high BMI have a higher renal capacity for uric acid reabsorption when fasted and following a dietary purine intake have reduced renal clearance.

Trial registration
Australia and New Zealand Clinical Trials Registry, ACTRN12615001302549, date of registration 30 November 2015.
Repeated sampling improved the sensitivity of malaria microscopy in children under six years
Authors: Aninagyei Enoch 
Published: November 2020

Abstract

Objective
Microscopy remains the gold standard for identification of malaria parasites. However, the sensitivity of malaria microscopy is low. This study evaluated the impact of repeated sampling up to 12 h in 177 children < 6 years with suspected malaria.

Results
The median age was 3 years (interquartile range, 2.0–4.0 years). Eighty-nine percent (158/177) presented with hyperthermia together with one or more of the following symptoms: chills, headache, sweating, fatigue, nausea, abdominal pain, vomiting, diarrhea and cough. Baseline microscopy confirmed malaria in 29.9% (53/177) of the suspects. Repeated testing at 6 and 12 h increased the positive detection rates to 35.0% (62/177) and 41.8% (74/177), respectively. Microscopy underestimated malaria diagnosis by 11.9% on single testing. Children showing classical signs of malaria but with initial negative parasitological reports should be retested between 6 to 12 h to confirm or rule out a diagnosis of malaria.
hPMSCs protects against d-galactose-induced oxidative damage of CD4+ T cells through activating Akt-mediated Nrf2 antioxidant signaling
Authors: Xiong Yanlian , Wang Yueming , Zhang Jiashen , Zhao Nannan , Zhang Hengchao , Zhang Aiping , Zhao Dongmei , Yu Zhenhai , Yin Yancun , Song Lele , Xiong Yanlei , Luan Xiying 
Published: November 2020

Abstract
Background
Mesenchymal stem cells (MSCs) were considered a regenerative therapeutic approach in both acute and chronic diseases. However, whether MSCs regulate the antioxidant metabolism of CD4+ T cells and weaken immunosenescence remains unclear. Here, we reported the protective effects of hPMSCs in aging-related CD4+ T cell senescence and identified the underlying mechanisms using a d-gal-induced mouse aging model.

Methods
In vivo study, 40 male C57BL/6 mice (8 weeks) were randomly divided into four groups: control group, d-gal group, hPMSC group, and PBS group. In in vitro experiment, human naive CD4+ T (CD4CD45RA) cells were prepared using a naive CD4+ T cell isolation kit II and pretreated with the Akt inhibitor LY294002 and Nrf2 inhibitor ML385. Then, isolated naive CD4+ T cell were co-cultured with hPMSCs for 72 h in the absence or presence of anti-CD3/CD28 Dynabeads and IL-2 as a mitogenic stimulus. Intracellular ROS changes were detected by flow cytometry. The activities of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and catalase were measured by colorimetric analysis. The senescent T cells were detected SA-β-gal stain. The expression of aging-related proteins was detected by Western blotting, RT-PCR, and confocal microscopy.

Results
We found that hPMSC treatment markedly decreased the ROS level, SA-β-gal-positive cells number, senescence-associated secretory phenotype (IL-6 and OPN) expression, and aging-related protein (P16 and P21) expression in senescent CD4+ T cells. Furthermore, hPMSC treatment effectively upregulated Nrf2 nuclear translocation and the expression of downstream target genes (HO-1, CAT, GCLC, and NQO1) in senescent CD4+ T cells. Moreover, in vitro studies revealed that hPMSCs attenuated CD4+ T cell senescence by upregulating the Akt/GSK-3β/Fyn pathway to activate Nrf2 functions. Conversely, the antioxidant effects of hPMSCs were blocked by the Akt inhibitor LY294002 and Nrf2 inhibitor ML385 in senescent CD4+ T cells.

Conclusions
Our results indicate that hPMSCs attenuate d-gal-induced CD4+ T cell senescence by activating Nrf2-mediated antioxidant defenses and that upregulation of Nrf2 by hPMSCs is regulated via the Akt/GSK-3β/Fyn pathway.
Multichannel speaker interference reduction using frequency domain adaptive filtering
Authors: Meyer Patrick , Elshamy Samy , Fingscheidt Tim 
Published: November 2020

AbstractMicrophone leakage or crosstalk is a common problem in multichannel close-talk audio recordings (e.g., meetings or live music performances), which occurs when a target signal does not only couple into its dedicated microphone, but also in all other microphone channels. For further signal processing such as automatic transcription of a meeting, a multichannel speaker interference reduction is required in order to eliminate the interfering speech signals in the microphone channels. The contribution of this paper is twofold: First, we consider multichannel close-talk recordings of a three-person meeting scenario with various different crosstalk levels. In order to eliminate the crosstalk in the target microphone channel, we extend a multichannel Wiener filter approach, which considers all individual microphone channels. Therefore, we integrate an adaptive filter method, which was originally proposed for acoustic echo cancellation (AEC), in order to obtain a well-performing interferer (noise) component estimation. This results in an improved speech-to-interferer ratio by up to 2.7 dB at constant or even better speech component quality. Second, since an AEC method requires typically clean reference channels, we investigate and report findings why the AEC algorithm is able to successfully estimate the interfering signals and the room impulse responses between the microphones of the interferer and the target speakers even though the reference signals are themselves disturbed by crosstalk in the considered meeting scenario.
Image restoration based on sparse representation using feature classification learning
Authors: Chang Minhui , Zhang Lei 
Published: November 2020

Abstract
In the image inpainting method based on sparse representation, the adaptability of over-complete dictionary has a great influence on the result of image restoration. If the over-complete dictionary cannot effectively reflect the differences between different local features, it may result in the loss of texture details, resulting in blurred or over-smooth phenomenon in restored images. In view of these problems, we propose an image restoration method based on sparse representation using feature classification learning. Firstly, we perform singular value decomposition on the local gradient vector. According to the relationship between the main orientation and the secondary orientation, we classify all the local patches into three categories: smooth patch, edge patch and texture patch. Secondly, we use K-Singular Value Decomposition method to learn over-complete dictionaries that adapt to different features. Finally, we use Orthogonal Matching Pursuit method to calculate the sparse coding of target patches with different local features on their corresponding over-complete dictionaries, and use the over-complete dictionary and corresponding sparse coding to restore the damaged pixels. A series of experiments on various restoration tasks show the superior performance of the proposed method.
Multimodality lymphatic imaging of postoperative chylothorax in an infant with Noonan syndrome: a case report
Authors: Pham Kay T. , Balaguru Duraisamy , Tammisetti Varaha S. , Guevara Carlos J. , Rasmussen John C. , Zvavanjanja Rodrick C. , Hanfland Robert , Sevick-Muraca Eva M. , Aldrich Melissa B. 
Published: November 2020

Abstract

Background
Chylothorax is a rare complication of pediatric cardiac operations that occurs more frequently in children with Noonan syndrome, a genetic disorder associated with cardiac defects and lymphatic anomalies.

Case presentation
We report a case of postoperative chylothorax in a 6-month-old infant with Noonan syndrome where multimodality lymphatic imaging guided management was followed. Drainage patterns of the lymphatic capillaries in the lower and upper extremities were visualized during near-infrared fluorescence lymphatic imaging (NIRFLI). Dynamic magnetic resonance lymphangiography (MRL) further identified the site of leakage in the thoracic duct and subsequently guided surgical intervention.

Conclusions
Application of multimodality imaging allows for greater individualization of treatment and should be considered in patients with complex cases such as those with syndromes associated with a higher incidence of chylothorax. IRB Number: HSC-MS-13–0754, December 10, 2013
What happens when you compare yourself to a model eating a cheeseburger? An experiment testing the impact of models promoting calorie-dense foods on beliefs about weight maintenance, body satisfaction, and purchase intent
Authors: Blomquist Kerstin K. , Schmalz Dorothy L. , Pate Sarah P. , Willmerdinger Alissa 
Published: November 2020

Abstract

Background
Ads depicting models promoting calorie-dense foods and beverages are ubiquitous and no known research has examined their effects on consumers. Drawing from social comparison theory, we hypothesized that participants who viewed ads with models (versus without models) would be more likely to rate models and less likely to rate themselves as able to consume the calorie-dense foods regularly and still maintain their weight/shape. We also hypothesized that participants who viewed ads with models (versus without models) would report more body dissatisfaction and, consistent with consumer research, a greater intention to purchase the product.

Methods
Participants (N = 168) were randomly assigned to view food or beverage ads with models or without models and completed self-report measures.

Results
Participants who viewed ads without models were more likely to rate themselves and most people as able to consume calorie-dense foods regularly and maintain their weight/shape and reported a greater intention to purchase the product. Consistent with our hypotheses, participants who viewed ads with models reported increased body dissatisfaction.

Conclusions
Results indicate that consumers’ perceptions of their own and others’ abilities to regularly consume calorie-dense foods and maintain their weight/shape change based on whether (or not) the calorie-dense foods are promoted by a model. Our findings reveal the nuanced negative effects of calorie-dense food ads with and without models and give insight into the psychological and potential physical health consequences that food ads can have on consumers.
A comparison of eating disorder symptomatology, psychological distress and psychosocial function between early, typical and later onset anorexia nervosa
Authors: Jenkins Zoe M. , Chait Lior M. , Cistullo Leonardo , Castle David J. 
Published: November 2020

AbstractObjectiveEpidemiological studies suggest that the incidence of anorexia nervosa (AN) is increasing in younger populations, with some evidence that clinical differences occur according to age of onset (AOO), which may impact prognostic outcomes. The current study sought to compare eating disorder (ED) symptomatology, psychological distress and psychosocial function between early onset (EO), typical onset (TO) and later onset (LO) AN in a large sample of treatment-seeking patients with a diagnosis of AN.MethodsParticipants included 249 individuals with a diagnosis of AN who were assessed at an outpatient ED service. The sample was divided into three groups based on AOO; those with an AOO ≤14 years (N = 58) were termed ‘EO-AN’, those with an AOO between 15 and 18 years (N = 113) were termed ‘TO-AN’ and those with an AOO of > 18 years (N = 78) were termed ‘LO-AN’. Comparisons were made between AOO groups on assessments of ED symptomatology, psychological distress and psychosocial function.ResultsEO-AN patients reported a significantly longer illness duration than both TO-AN and LO-AN groups. After controlling for effect of illness duration, the EO-AN group demonstrated significantly higher ED symptomatology and dysmorphic concern compared to the LO-AN group. The EO-AN group demonstrated significantly decreased cognitive flexibility compared to both the TO-AN and LO-AN groups.DiscussionThese findings suggest that clinical differences do occur according to AOO in AN whereby EO-AN may represent a more severe form of illness that is not attributable to increased illness duration. Treatment strategies which specifically address patients with EO-AN may improve long term health outcomes and recovery.
Cell-free DNA and circulating TERT promoter mutation for disease monitoring in newly-diagnosed glioblastoma
Authors: Fontanilles Maxime , Marguet Florent , Beaussire Ludivine , Magne Nicolas , Pépin Louis-Ferdinand , Alexandru Cristina , Tennevet Isabelle , Hanzen Chantal , Langlois Olivier , Jardin Fabrice , Laquerrière Annie , Sarafan-Vasseur Nasrin , Di Fiore Fréderic , Clatot Florian 
Published: November 2020

AbstractThe clinical implications of plasmatic cell-free and tumor DNA (cfDNA and ctDNA) are challenging in glioblastoma. This prospective study included 52 consecutive newly diagnosed glioblastoma (n = 49) or gliosarcoma (n = 3) patients treated with concomitant temozolomide and radiotherapy (RT-TMZ), followed by a TMZ maintenance phase. Plasma samples were collected at baseline, before RT-TMZ (pre-RT-TMZ) and at the end of adjuvant TMZ, or at the time of progression in cases of progressive disease (PD). The cfDNA concentration was measured with a fluorometric method, and ctDNA was detected using targeted droplet digital PCR. The main objectives were to analyze the associations between cfDNA and ctDNA measurements during the course of treatment with PD and survival. There was a significant decrease in median cfDNA concentration from baseline to pre-RT-TMZ—19.4 versus 9.7 ng/mL (p < 0.0001)—in the entire cohort. In patients with PD, a significant increase in cfDNA concentration from pre-RT-TMZ to time of PD was observed, from 9.7 versus 13.1 ng/mL (p = 0.037), respectively, while no difference was observed for nonprogressive patients. Neither the cfDNA concentration at baseline nor its kinetics correlated with survival. ctDNA was detected in 2 patients (3.8%) and only in gliosarcoma subtypes.Trial registration ClinicalTrial, NCT02617745. Registered 1 December 2015, https://clinicaltrials.gov/ct2/show/NCT02617745?term=glioplak&draw=2&rank=1.
CatBoost for big data: an interdisciplinary review
Authors: Hancock John T. , Khoshgoftaar Taghi M. 
Published: November 2020

AbstractGradient Boosted Decision Trees (GBDT’s) are a powerful tool for classification and regression tasks in Big Data. Researchers should be familiar with the strengths and weaknesses of current implementations of GBDT’s in order to use them effectively and make successful contributions. CatBoost is a member of the family of GBDT machine learning ensemble techniques. Since its debut in late 2018, researchers have successfully used CatBoost for machine learning studies involving Big Data. We take this opportunity to review recent research on CatBoost as it relates to Big Data, and learn best practices from studies that cast CatBoost in a positive light, as well as studies where CatBoost does not outshine other techniques, since we can learn lessons from both types of scenarios. Furthermore, as a Decision Tree based algorithm, CatBoost is well-suited to machine learning tasks involving categorical, heterogeneous data. Recent work across multiple disciplines illustrates CatBoost’s effectiveness and shortcomings in classification and regression tasks. Another important issue we expose in literature on CatBoost is its sensitivity to hyper-parameters and the importance of hyper-parameter tuning. One contribution we make is to take an interdisciplinary approach to cover studies related to CatBoost in a single work. This provides researchers an in-depth understanding to help clarify proper application of CatBoost in solving problems. To the best of our knowledge, this is the first survey that studies all works related to CatBoost in a single publication.
Association of macular perfusion status with microvascular parameters up to the far periphery in diabetic retinopathy using multimodal imaging
Authors: Hajdu Dorottya , Sedova Aleksandra , Datlinger Felix , Hafner Julia , Steiner Irene , Kriechbaum Katharina , Scholda Christoph , Sacu Stefan , Schmidt-Erfurth Ursula , Pollreisz Andreas 
Published: November 2020

Abstract

Background
The aim of our study was to investigate a possible association between macular perfusion status and retinal ischemia and leakage up to far peripheral retinal areas in eyes with early to advanced stages of diabetic retinopathy (DR).

Methods
In a retrospective, cross sectional analysis ultrawide field (UWF) color fundus photos (Optos, Optomap California) were graded for DR severity. Foveal avascular zone (FAZ) and vessel density from the superficial (SCP) and deep capillary plexus (DCP) were assessed on optical coherence tomography angiography (OCTA) scans (Topcon, DRI-OCT Triton). UWF angiography images were used to quantify leakage/ischemic index and number of microaneurysms (MA). Age, gender, disease duration, type of diabetes, HbA1C, hypertension, complications of diabetes and ocular history were recorded. Univariate mixed models and Spearman correlation analysis were used for statistical testing.

Results
24 eyes of 17 laser-naive diabetic patients with different stages of DR were analyzed. The mean age was 59.56 ± 8.46 years and the mean disease duration 19.65 ± 12.25 years. No statistically significant associations between FAZ size, macular vessel density of SCP/DCP and peripheral retinal ischemia, leakage and MA number were demonstrated. Higher stages of DR were associated with ischemic index (estimate [95% CI]: 13.04 [1.5; 24.5], p = 0.033) and MA count (estimate [95% CI]: 43.7 [15.6; 71.8], p = 0.01), but no association with leakage index was observed. Only weak correlations between DR severity and anamnestic data were found.

Conclusion
Retinal ischemic index and the amount of MAs assessed on UWFA up to peripheral areas are indicators of DR severity but not related to microvascular perfusion status in the macular region. Significance and timely sequence of macular vessel density in DR progression may need to be re-evaluated in future studies.
Length scales and scale-free dynamics of dislocations in dense solid solutions
Authors: Péterffy Gábor , Ispánovity Péter D. , Foster Michael E. , Zhou Xiaowang , Sills Ryan B. 
Published: November 2020

AbstractThe fundamental interactions between an edge dislocation and a random solid solution are studied by analyzing dislocation line roughness profiles obtained from molecular dynamics simulations of Fe0.70Ni0.11Cr0.19over a range of stresses and temperatures. These roughness profiles reveal the hallmark features of a depinning transition. Namely, below a temperature-dependent critical stress, the dislocation line exhibits roughness in two different length scale regimes which are divided by a so-called correlation length. This correlation length increases with applied stress and at the critical stress (depinning transition or yield stress) formally goes to infinity. Above the critical stress, the line roughness profile converges to that of a random noise field. Motivated by these results, a physical model is developed based on the notion of coherent line bowing over all length scales below the correlation length. Above the correlation length, the solute field prohibits such coherent line bow outs. Using this model, we identify potential gaps in existing theories of solid solution strengthening and show that recent observations of length-dependent dislocation mobilities can be rationalized.