bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward improved impact evaluation of community forest management in Indonesia
Authors: Meijaard Erik , Santika Truly , Wilson Kerrie A. , Budiharta Sugeng , Kusworo Ahmad , Law Elizabeth A. , Friedman Rachel , Hutabarat Joseph A. , Indrawan Tito P. , Sherman Julie , St. John Freya A. V. , Struebig Matthew J. 
Published: February 2020

AbstractMany tropical countries continue to devolve forest management to forest‐dwelling communities. The assumption is that local knowledge of forests and community engagement in forest management will attain multiple social and environmental co‐benefits, such as poverty alleviation and reduced deforestation and fires. Evidence for this, however, is scant, commonly hampered by data availability and a lack of technical capacity for implementing statistically robust impact evaluations. Based on a practice‐based review of policy implementation, impact evaluation of case studies and examples of counterfactual analyses from Indonesia, we demonstrate that it is increasingly feasible to determine the conditions under which community forest management will most likely achieve its social and environmental objectives. Adapting community forest management implementation based on feedback from accurate impact evaluation could lead to positive outcomes for people and environment in Indonesia, and across the tropical realm.
Disparities in DCD organ procurement policy from a national OPO survey: A call for standardization
Authors: Choubey Ankur Pranjal , Siskind Eric J. , Ortiz Alex C. , Nayebpour Mehdi , Koizumi Naoru , Wiederhold Paul , Ortiz Jorge 
Published: February 2020

AbstractIntroductionProcurement practices across organ procurement organizations (OPOs) for donation after cardiac death (DCD) transplants have not been evaluated.MethodsA national telephone survey of all 58 OPOs inquiring about their procurement practices of DCD organs was conducted. Policies concerning maximum donor body mass index (BMI), location of care withdrawal, pre‐mortem heparin administration, vasodilator use, wait times after declaration of death before incisions, inclinations between rapid laparotomy and pre‐mortem cannulation, and maximum time before aborting DCD procurement were queried.ResultsThe survey revealed substantial differences across OPOs. Donor BMI restriction was considered by 36 of 58 OPOs, and 23 sites preferred OR for donor withdrawal of care. Pre‐mortem heparin was utilized by 53 OPOs. Only 2 recommended vasodilators. Minimum wait time of 5‐minutes was implemented by 41 OPOs. Rapid laparotomy was preferred by 57 organizations. 28 OPOs had a 90‐minute limit before aborting DCD procurement.ConclusionThere are substantial variations across OPO protocols for procuring DCD organs. Current practices do not conform to ASTS guidelines for DCD procurement. Further investigations are needed to quantify the impact of OPO policies on transplant outcomes.
Temporary contraindication of obese recipients in kidney transplantation: A new morphometric tool for decision support
Authors: Pinar Ugo , Renard Yohann , Bedretdinova Dina , Parier Bastien , Hammoudi Yacine , Irani Jacques , Bessede Thomas 
Published: February 2020

AbstractBackgroundMorbid obesity, based on body mass index (BMI) and/or clinical examination, can be a temporary contraindication (TCI) of kidney transplantation. However, BMI alone does not evaluate the intra‐ or extra‐peritoneal distribution of fatty tissue, and clinical examination alone is subjective. The objective was to evaluate the interest of morphometric criteria to ensure reproducible and consensual decision of TCI.MethodsWe retrospectively included patients with a BMI >30 transplanted or temporarily contraindicated because of their weight from 2012 to 2017. The following measurements were performed on CT scan sections using a semiautomatic Hounsfield density detection software: subcutaneous adipose tissue surface (SAT), visceral adipose tissue surface (VAT), vessel‐to‐skin distance (VSK), abdominal perimeter (AP), and psoas index. Performance of morphometric measures to predict TCI was assessed through ROC analysis.ResultsNinety‐seven patients were included: 76 kidney transplant recipients and 21 on the TCI list. The area under the curve (AUC, 95%CI) for the BMI model to predict TCI was 0.81 (0.72‐0.90). A 5‐variable model including BMI, VAT, VSK, AP, and age gave an AUC of 0.88 (0.78‐0.98).ConclusionsMorphometric obesity parameters are associated with TCI decision‐making for kidney transplantation: When combined with BMI in a “morphometric tool,” they were predictive of a TCI decision.
Monetary Policies versus Regulatory Policies: Management of Peer to Peer Market Interest Rates
Authors: Li Cangshu 
Published: February 2020

AbstractThis paper studies how monetary and regulatory policies manage peer to peer (P2P) interest rates. Based on selected representative monetary and regulatory policies, this paper finds that easy monetary policies reduce the demand for online loans, thus reducing the market's interest rates. Monetary policies may increase the supply of online loans through rational expectation channels or reduce the demand for online loans through bank risk‐taking channels. Normative market‐based regulatory policy enables the P2P market to return to rationality, eliminates high‐risk investors and borrowers, and subsequently reduces market interest rates. Risk disposal‐based regulatory policy reduces market supply to some extent, resulting in a small increase in interest rates. Both easy monetary policies and regulatory policies have a great impact on the normal platforms. The interest rate of high‐risk platforms is less affected by the relevant policies, which is evidence that such platforms do not behave in accordance with the financial rules in general. Monetary policies mainly affect platforms with interest rates in a relatively normal range, while regulatory policies mainly focus on platforms with abnormal interest rates.
Monetary Policy and Borrowers’ Loan Defaults: Research Based on Data from Renrendai
Authors: Song Wenda , Zhang Haiyang 
Published: February 2020

AbstractThis paper uses Renrendai data to study the relationship between monetary policy and the default behavior of borrowers, and analyzes the transmission channels. The research shows that tight monetary policy will lead to a significant increase in a borrower's probability to default, and this effect will continue for several months. There may be two transmission channels: (i) monetary policy changes a debtor's liquidity through credit and balance sheet channels, which directly affects their current repayment behavior; and (ii) monetary policy may affect a borrower's investment, production and profitability, thus changing their long‐term solvency. The paper also finds that the repayment behavior of productive borrowers is more susceptible to monetary policy than consumptive borrowers, and that the default behavior of borrowers in coastal provinces is more susceptible to monetary policy than of borrowers in inland provinces. These findings provide new evidence for understanding how monetary policy affects individual behavior and its transmission mechanisms.
Quantitative image analysis for CD8 score in lung small biopsies and cytology cell‐blocks
Authors: Monaco Sara E. , Dacic Sanja , Seigh Lindsey , Hartman Douglas J. , Xing Juan , Pantanowitz Liron 
Published: February 2020

AbstractIntroductionImmunotherapy has shown promising results in non‐small cell lung cancer (NSCLC), for which tumour‐infiltrating cytotoxic (CD8+) T cells play a critical role. We investigated the utility of image analysis (IA) to quantify CD8+ T cells in a series of matched small biopsies and resections of NSCLC.MethodsCD8 immunohistochemistry was performed on cell‐blocks (CB), core needle biopsies (CNB) and corresponding resections from primary NSCLCs. Slides were digitised using an Aperio AT2 scanner (Leica) and annotated by whole slide image (WSI) or fields of view occupied by tissue spots (TS). Quantitative IA was performed with a customised Aperio algorithm (Leica). CD8 scores (number of T cells with 1‐3+ staining/total area) were then compared.ResultsForty‐four cases with CB or CNB material and a corresponding resection were analysed. Average CD8 score was determined in CB (7.67 WSI, 77.67 TS) and/or CNB (47.35 WSI, 325.67 TS), and corresponding resections (190.35 WSI, 336.58 TS). CD8 score concordance was highest (78.6%) for CNBs using WSI annotation. Overall, small biopsies (CB or CNB) correlated with the resection in 71.4% cases using WSI and 63.3% cases using TS annotation. IA performed better for low CD8 scores.ConclusionsThese findings show that CD8 density in NSCLC can be quantified by IA in small biopsies and cell blocks, achieving the best concordance using WSI scores. Discrepancies were attributed to values near the cut‐off and background detection of staining. These data warrant future studies with more cases and follow‐up data to further investigate the clinical utility of IA for CD8 analysis in NSCLC.
Hereditary angioedema in a single family with specific mutations in both plasminogen and SERPING1 genes
Authors: Bork Konrad , Zibat Arne , Ferrari David M. , Wollnik Bernd , Schön Michael P. , Wulff Karin , Lippert Undine 
Published: February 2020

SummaryBackgroundHereditary angioedema (HAE) is a group of genetic diseases characterized by recurrent, painful and potentially lethal tissue swelling. The most common form results from mutations in the SERPING1 gene, leading to reduced function of complement 1 inhibitor (C1‐INH). Rarer forms with normal C1‐INH may arise from mutations in the coagulation factor F12 gene, but mostly the genetic background is unknown. Recently, a novel HAE mutation in the plasminogen (PLG) gene was shown.Patients and methodsWe analyzed the various clinical manifestations of HAE in 14 related patients using clinical data, biochemical analysis for C1‐INH and C4 as well as gene sequencing.ResultsPatients’ symptoms were assigned to two different forms of HAE. In ten patients suffering from swelling of the lips or tongue but not of the extremities, a mutation in the PLG gene (c.988A>G) was found whereas in the only four patients with swelling of the gastrointestinal tract and extremities, a mutation in the SERPING1 gene (c.1480C>T) was identified. In two cases this was additional to PLG c.988A>G.ConclusionsThis unique finding of two different HAE‐specific mutations in a large family not only explains the divergent phenotypes but also supports a genotype‐phenotype correlation showing that abdominal attacks and swelling of the extremities are common with HAE‐C1‐INH but unusual with HAE‐PLG.
Cross‐sectional and longitudinal associations between probable rapid eye movement sleep behavior disorder and impulse control disorders in Parkinson’s disease
Authors: Cao R. , Chen X. , Xing F. , Xie C. , Hu P. , Wang K. 
Published: February 2020

Background and purposeThe aim was to investigate whether probable rapid eye movement sleep behavior disorder (pRBD) is associated with impulse control disorders (ICDs) in drug‐naïve patients with Parkinson’s disease (PD) and whether baseline pRBD is associated with a higher incidence of ICDs during follow‐up.MethodsThe Parkinson’s Progression Markers Initiative is an international, multicenter, prospective cohort study to identify biomarkers of PD progression. In all, 423 drug‐naïve patients with early‐stage PD were included in the cross‐sectional analysis, and 320 patients who screened negative for any ICDs or related behaviors at baseline were included in the longitudinal analysis.ResultsIn the cross‐sectional analysis, a significant correlation was found between pRBD and ICDs in drug‐naïve patients whilst controlling for potential confounders [odds ratio 2.56, 95% confidence interval (CI) 1.38–4.76, P = 0.003]. In the longitudinal analysis, baseline pRBD was an independent predictor of ICD development over time [hazard ratio (HR) 1.648, 95% CI 1.054–2.576; P = 0.028]. Other significant predictors of ICDs included younger age of onset (HR = 0.973, 95% CI = 0.950–0.997; P = 0.026) and greater State‐Trait Anxiety Inventory score (HR = 1.040, 95% CI = 1.020–1.061; P < 0.001).ConclusionOur data suggest that identifying baseline pRBD in early‐stage PD may help clinicians to choose a better therapeutic strategy so as to prevent or limit neuropsychiatric complications.
Leaving uncut refuges during meadow harvesting increases the functional diversity of Orthoptera
Authors: Kaláb Oto , Šipoš Jan , Kočárek Petr 
Published: February 2020

AbstractIn the past, insect species richness was high in Central European seminatural grasslands, which were characterized by low‐intensity land use. Currently, however, the hay in most of these grasslands is mechanically harvested, which negatively impacts insect biodiversity. One way to reduce this negative effect is to leave unmown patches as refuges. In the current research we evaluated the short‐term effects of leaving an unmown patch on the taxonomic and functional diversity of the Orthoptera assemblage in a meadow. We found that orthopteran species richness and abundance were significantly reduced by mowing, whether or not a patch was left uncut. In contrast, functional evenness, indicating distribution of species abundances in a niche space, was reduced by mowing only if the plot lacked an uncut refuge. Functional richness, indicating the amount of niche space occupied by species, was elevated if the plot had an uncut refuge. Larger species were negatively affected by mowing, while habitat specialists, mobile species and soil‐ovipositing species benefitted from it. We infer that the presence of an uncut patch increased the diversity of habitats available to orthopterans and maintained even distribution of species among niche space. In summary, leaving an unmown refuge in grasslands could increase the functional diversity of orthopterans, even if it does not preserve taxonomic diversity.
Prior adaptation of parasitoids improves biological control of symbiont‐protected pests
Authors: Rossbacher Silvan , Vorburger Christoph 
Published: February 2020

AbstractThere is increasing demand for sustainable pest management to reduce harmful effects of pesticides on the environment and human health. For pest aphids, biological control with parasitoid wasps provides a welcome alternative, particularly in greenhouses. However, aphids are frequently infected with the heritable bacterial endosymbiont Hamiltonella defensa, which increases resistance to parasitoids and thereby hampers biological control. Using the black bean aphid (Aphis fabae) and its main parasitoid Lysiphlebus fabarum, we tested whether prior adaptation of parasitoids can improve the control of symbiont‐protected pests. We had parasitoid lines adapted to two different strains of H. defensa by experimental evolution, as well as parasitoids evolved on H. defensa‐free aphids. We compared their ability to control caged aphid populations comprising 60% unprotected and 40% H. defensa‐protected aphids, with both H. defensa strains present in the populations. Parasitoids that were not adapted to H. defensa had virtually no effect on aphid population dynamics compared to parasitoid‐free controls, but one of the adapted lines and a mixture of both adapted lines controlled aphids successfully, strongly benefitting plant growth. Selection by parasitoids altered aphid population composition in a very specific manner. Aphid populations became dominated by H. defensa‐protected aphids in the presence of parasitoids, and each adapted parasitoid line selected for the H. defensa strain it was not adapted to. This study shows, for the first time, that prior adaptation of parasitoids improves biological control of symbiont‐protected pests, but the high specificity of parasitoid counter‐resistance may represent a challenge for its implementation.
Glycosylation of hyperthermostable designer cellulosome components yields enhanced stability and cellulose hydrolysis
Authors: Kahn Amaranta , Moraïs Sarah , Chung Daehwan , Sarai Nicholas S. , Hengge Neal N. , Kahn Audrey , Himmel Michael E. , Bayer Edward A. , Bomble Yannick J. 
Published: February 2020

Biomass deconstruction remains integral for enabling second‐generation biofuel production at scale. However, several steps necessary to achieve significant solubilization of biomass, notably harsh pretreatment conditions, impose economic barriers to commercialization. By employing hyperthermostable cellulase machinery, biomass deconstruction can be made more efficient, leading to milder pretreatment conditions and ultimately lower production costs. The hyperthermophilic bacterium Caldicellulosiruptor bescii produces extremely active hyperthermostable cellulases, including the hyperactive multifunctional cellulase CbCel9A/Cel48A. Recombinant CbCel9A/Cel48A components have been previously produced in Escherichia coli and integrated into synthetic hyperthermophilic designer cellulosome complexes. Since then, glycosylation has been shown to be vital for the high activity and stability of CbCel9A/Cel48A. Here, we studied the impact of glycosylation on a hyperthermostable designer cellulosome system in which two of the cellulosomal components, the scaffoldin and the GH9 domain of CbCel9A/Cel48A, were glycosylated as a consequence of employing Ca. bescii as an expression host. Inclusion of the glycosylated components yielded an active cellulosome system that exhibited long‐term stability at 75 °C. The resulting glycosylated designer cellulosomes showed significantly greater synergistic activity compared to the enzymatic components alone, as well as higher thermostability than the analogous nonglycosylated designer cellulosomes. These results indicate that glycosylation can be used as an essential engineering tool to improve the properties of designer cellulosomes. Additionally, Ca. bescii was shown to be an attractive candidate for production of glycosylated designer cellulosome components, which may further promote the viability of this bacterium both as a cellulase expression host and as a potential consolidated bioprocessing platform organism.
Which are the best environmental conditions for catching the beach‐seine target species? A Portuguese case study
Authors: Teixeira Célia M. , Silva Priscila M. , Gamito Rita , Amoroso Sandra , Lopes Nuno , Freitas Catarina , Cabral Henrique N. , Costa José L. 
Published: February 2020

AbstractThe beach‐seine fishery is a commercial fishing activity on the Portuguese coast, with reports dating as far back as the early 15th century. The main target species of this fishery are small pelagic fish such as Atlantic chub mackerel, Atlantic horse mackerel and sardine. To identify the best conditions for fishing the target species, catches of beach seine (2007–2017) were used and generalized linear models were applied, using a binomial and gamma distributions. The logistic model explained between 36.3% and 45.7% of the catches variability; the gamma model explained 9.1% and 46.9% of the catches variability, being month and wind direction the best covariates for the occurrence and/or abundance of the three small pelagic fishes in analysis. If the effort is directed to the days that meet the conditions found for each species (sardine: between May and October, wind NW, daytime; Atlantic horse mackerel: May, NW/NE wind, 800 m from the coastline; Atlantic chub mackerel: from July to August, NW moderate wind), a reduction in bycatch and discards can be achieved. This approach can have a positive economic and social impact, since it provides information for turning fisheries more efficient.
Reliability and construct validity of a novel motor–cognitive dual‐task test: A Stepping Trail Making Test
Authors: Osuka Yosuke , Kojima Narumi , Sakurai Ryota , Watanabe Yutaka , Kim Hunkyung 
Published: February 2020

AimThis study aimed to examine the reliability and construct validity of the Stepping Trail Making Test (S‐TMT) in community‐dwelling older adults.MethodsThis study comprised a cross‐sectional study based on a population sample. Participants comprised 1224 community‐dwelling older Japanese women aged 65–81 years without functional disability, dementia, depression, Parkinson's disease, or cognitive and visual impairments. The S‐TMT measured the time taken to step on a sequence of numbers (1–16) positioned on a mat (1 m2). Participants were instructed to step as quickly and accurately as possible. Motor functions were assessed by walking speed and knee extensor strength tests, while cognitive functions were assessed by the Symbol Digit Substitution Task (SDST) test, verbal and logical memory test, and TMT‐A and ‐B.ResultsAs a result of test–retest reliability over 6 months, the intraclass correlation coefficients of the S‐TMT was 0.82 (95% confidence interval, 0.68–0.90). An adjusted multiple regression model indicated that the S‐TMT was significantly associated with walking speed for motor function, and associated with the SDST, TMT‐A and TMT‐B for cognitive functions (P < 0.001).ConclusionsThese results suggest that the S‐TMT is a reliable dual‐task test comprising mobility for motor function and a visual‐dependent execution function for cognitive function in older women. Geriatr Gerontol Int 2020; 20: 291–296.
Retracted: Effect of driving domain on driving attitude profiles in winter seasons of India
Authors: Adhikari Biranchi Narayan , Behera Ajay Kumar , Mahapatra Rabindra Narayan , Das Harish Chandra 
Published: February 2020

AbstractThe trademark of motor vehicle use and driving attitude profiles explores new safety upgrades and energy redemption because of the role of driving attitude profiles and driving domains on road mishaps and traffic intensities. Thus, the goal of this research was to identify driving attitude profiles for multiple driving domains (on the basis of speed limits and winter conditions) from real‐world driving information and to investigate how these driving environments have an impact on driving attitude profiles. The study for this research was located in Bhubaneswar, India, where driving information from 64 motorists was collected with Fog Monitor (FM‐120) for at least 12 months. The outcomes indicate that both speed limits and winter states influence driving attitude profiles significantly. Specifically, for winter states, the outcomes provide authentication that motorists drive more quietly (normal speed is 21% lower for zero visibility (visibility < 100 m) than under haze conditions (visibility: 2–5 km), while positive and negative accelerations decrease by 7% and 9%, respectively), when deliberating the effect of speed limit more local streets (limits II, III, and IV streets) are the ones that present more reckless driving profiles in terms of acceleration (30%–40% increase from limit I to limit IV streets). The contribution of this study regards the quantification of the impacts of driving domains on driving attitude profiles, providing evidence that winter conditions significantly affect driving attitude profiles, leading motorists to adjust their driving attitude profiles to the driving domains. However, regarding the speed limit, the differences found in driving attitude profiles seem to be more a consequence of the infrastructure characteristics than an adjustment of driving attitude profiles.