bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of barley net blotch using Trichoderma asperellum (T34), eugenol, non-traditional compounds and fungicides
Authors: Hafez Yaser , Abdelfatah Amr , El-Nashar Faten , Badr Mahmoud , Elkady Sayed 
Published: December 2019

AbstractBarley plants (cv. Giza 2000) are infected by Drechslera teres which causes net blotch disease symptoms and yield losses. Plants were treated with commercial molecular products such as Trichoderma asperilium (T34), eugenol compared to non-traditional compounds (potassium silicate, nano-selenium) and fungicides (Maven, Montoro, and Decent) which selected from 12 treatments according to their important effects on infected barley plants. Bio-arc, Tilt, Rush up, Curve, and Amisto treatments were left out because of their lower efficiency of some treatments and similarity of the active ingredients of some other of them.Disease severity (%) was significantlty decreased as a result of the selected treatments, except eugenol which showed less reduction than the control. Disease symptoms were suppressed and electrolyte leakage % was reduced significantly due to all treatments than the control treatment. As a consequence of treatments, endogenous reactive oxygen species (ROS) such as superoxide (O2−) was significantly elevated early after the inoculation, consequently, later on catalase (CAT), peroxidase (POX), and polyphenol oxidase (PPO) activities were increased significantly than the control. Elevated levels of O2− early after inoculation could play essential role in killing or suppressing the fungus and inhibiting disease symptoms as well as stimulated enzyme activities. Interestingly, the treatments were effective so that the yield characters (1000 K.W. and grain yield/plo) were increased significantly than the control treatment. These results indicated that the biological commercial product of Trichoderma asperilium 34 and non-traditional biological compounds in this research study are so effective and could be used as an alternative to fungicides.
Toll-like receptors activation, signaling, and targeting: an overview
Authors: El-Zayat Salwa Refat , Sibaii Hiba , Mannaa Fathia A. 
Published: December 2019

Abstract
Background
Toll-like receptors (TLRs) are an important family of receptors that constitute the first line of defense system against microbes. They can recognize both invading pathogens and endogenous danger molecules released from dying cells and damaged tissues and play a key role in linking innate and adaptive immunity. TLRs are widely distributed in both immune and other body cells. The expressions and locations of TLRs are regulated in response to specific molecules derived from pathogens or damaged host cells. The binding of ligands to TLR activates specific intracellular signaling cascades that initiate host defense reactions. Such binding is ligand-dependent and cell type-dependent and leads to production of pro-inflammatory cytokines and type 1 interferon. TLR-dependent signaling pathways are tightly increased during innate immune responses by a variety of negative regulators. Overactivation of TLRs can ultimately lead to disruption of immune homeostasis and thus increase the risk for inflammatory diseases and autoimmune disorders. Antagonists/inhibitors targeting the TLR signaling pathways have emerged as novel therapeutics to treat these diseases.

Aim of work
The present review summarizes the structure, characterizations, and signaling of TLRs and their regulators, as well as describes the implication of TLRs in many diseases with a brief idea about the inhibitors that target TLR signaling pathways.

Conclusion
We conclude that TLRs are the main elements of our immune system, and they should be maintained functioning to keep the integrity of innate immunity. Targeting of TLR signaling represents a new challenge for treatment of many diseases.
Ethnomedicine and ethnobotany of Maerua subcordata (Gilg) DeWolf
Authors: Hiben Mebrahtom Gebrelibanos , Louisse Jochem , de Haan Laura H.J. , Rietjens Ivonne M. C. M. 
Published: December 2019

Abstract
Background
Wild edible plants are valuable resources for improving food and nutritional security. Besides, they may provide important health benefits since the health-promoting components of plant-based foods usually exist at higher levels in wild plants. As a result, they are being sought as under-exploited potential sources of a health-promoting diet or a possible strategy to develop novel foods. In such exploration, ethnobotanical and ethnomedicinal data offer a fundamental step. The present study provides ethnomedicinal data on Maerua subcordata (Gilg) DeWolf (Capparidaceae).

Methods
The ethnomedicinal data was collected from the Kunama ethnics of northern Ethiopia via focus group discussion and oral interview. Supporting ethnobotanical data from relevant literature was also compiled and systematically reviewed.

Results
The results show that M. subcordata tuber is used by the Kunamas to manage malaria, malaria symptoms (fever, pain, gastrointestinal disorders), and seasonal cough while leaves are used for wound healing. In east Africa, its triple potential use as water purifying agent, food item, and herbal medicine was specified. As a herbal medicine, the tuber is used to manage a wide range of disorders including pain, infections, wounds, diabetes, blood pressure, and loss of appetite. Its use as laxative and abortifacient was also indicated. Leaves are used to treat wounds and ophthalmic and respiratory problems. As a food item, fruits are eaten during times of both food scarcity and food abundance while the tuber is used as a famine food.

Conclusion
In East Africa, M. subcordata represents a wild food and medicinal plant, which may be developed into a functional food.
Influence of workshop attendance on management of pediatric fecal incontinence in Nigeria
Authors: Lawal Taiwo Akeem 
Published: December 2019

Abstract
Background
The care of children with fecal incontinence is suboptimal with inadequate support and training opportunities. The postgraduate training of pediatric surgeons on the management of fecal incontinence is inadequate since each training center is not likely to see enough number of cases yearly. Supplemental training through workshops on fecal incontinence may help to bridge the gap. The aim of this cross sectional study was to evaluate the impact of previous attendance of a workshop on fecal incontinence management practices among pediatric surgeons.

Results
A total of 41 respondents participated. Eleven (26.8%) respondents had attended a workshop in the past and seven (17.1%) had done a Malone antegrade continent enema (MACE) on patients. A higher proportion of respondents who had practiced for over 15 years had attended a workshop on fecal incontinence compared to those who had not attended one (90.9% vs. 33.3%, p = 0.001). The proportion of respondents who had attended a workshop on fecal incontinence and had performed a MACE (18.2%) was higher than the proportion of those who had not attended a workshop and had performed a similar procedure on patients (3.3%), p = 0.047.

Conclusions
One quarter of pediatric surgeons in the country surveyed had attended a workshop on fecal incontinence. Prior attendance of a workshop on fecal incontinence is significantly related to experience and significantly influenced the performance of a MACE procedure. Supplementation of the training of pediatric surgeons through workshops on fecal incontinence will help to improve capacity in pediatric colorectal surgical care.
Calcitriol Elevation Is Associated with a Higher Risk of Refractory Hypercalcemia of Malignancy in Solid Tumors
Authors: Chukir Tariq , Liu Yi , Hoffman Katherine , Bilezikian John P , Farooki Azeez 
Published: December 2019

Abstract

Background
Hypercalcemia of malignancy (HCM) is a common complication of advanced cancer. PTH-independent HCM may be mediated through different mechanisms: (1) humoral HCM, caused by the secretion of PTH-related peptide (PTHrP), (2) local osteolysis resulting from metastatic lesions, and (3) calcitriol-mediated hypercalcemia. Calcitriol-mediated HCM in patients with nonlymphomatous solid tumors is thought to be rare.

Methods
We performed a retrospective chart review from 2008 to 2017 to characterize further patients at our institution with solid tumors who had HCM with concomitant elevations in calcitriol. Patients with PTH-dependent hypercalcemia and patients with evidence of granulomatous disease were excluded, as were patients with hematologic malignancies. We hypothesized that patients with HCM and elevated calcitriol levels would respond less favorably to treatment with antiresorptive therapy compared with patients with HCM but without calcitriol elevation. We also aimed to assess mortality and determine if PTHrP and phosphorus levels correlate with calcitriol because both factors may alter calcitriol levels.

Results
Of 101 eligible patients, calcitriol was elevated in 45 (45%). PTHrP was elevated in 76% of patients with elevated calcitriol compared with 52% of patients without calcitriol elevation. The mean PTHrP value did not differ between patients with HCM and elevated calcitriol (36.3 ± 22 pg/mL) and those without calcitriol elevation (37.4 ± 19 pg/mL). Those with elevated calcitriol levels generally did not respond completely to antiresorptive treatment (80% incomplete response rate), whereas most patients without an elevation in calcitriol responded well to antiresorptive treatment (78% response rate: P &lt; .001). There was no significant difference in the percentage of patients with metastatic bone disease among the 2 groups (49% vs. 55%, respectively). There was no difference in mortality between the 2 groups (P = .14). A weak but significant negative correlation was found between phosphorus and calcitriol (Pearson r = -0.261, P = .016). This correlation was only significant in patients without calcitriol elevation (Pearson r = -0.4, P = .0082). Also, a significant negative correlation was found between PTHrP and phosphorus, again only in patients without calcitriol elevation.

Discussion
In the setting of HCM, patients with calcitriol elevation are much less likely to respond to antiresorptive therapy than patients without calcitriol elevation. Because calcitriol elevation did not appear to be correlated with hypophosphatemia or elevated PTHrP, it would appear that calcitriol production under these conditions is autonomous, and not subject to normal physiological controls. These observations indicate that calcitriol elevations in patients with HCM have clinical significance.
AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells
Authors: Kroll Jana , Özçete Özge Demet , Jung Sangyong , Maritzen Tanja , Milosevic Ira , Wichmann Carolin , Moser Tobias 
Published: December 2019

ABSTRACT
High-throughput neurotransmission at ribbon synapses of cochlear inner hair cells (IHCs) requires tight coupling of neurotransmitter release and balanced recycling of synaptic vesicles (SVs) as well as rapid restoration of release sites. Here, we examined the role of the adaptor protein AP180 (also known as SNAP91) for IHC synaptic transmission by comparing AP180-knockout (KO) and wild-type mice using high-pressure freezing and electron tomography, confocal microscopy, patch-clamp membrane capacitance measurements and systems physiology. AP180 was found predominantly at the synaptic pole of IHCs. AP180-deficient IHCs had severely reduced SV numbers, slowed endocytic membrane retrieval and accumulated endocytic intermediates near ribbon synapses, indicating that AP180 is required for clathrin-dependent endocytosis and SV reformation in IHCs. Moreover, AP180 deletion led to a high prevalence of SVs in a multi-tethered or docked state after stimulation, a reduced rate of SV replenishment and a hearing impairment. We conclude that, in addition to its role in clathrin recruitment, AP180 contributes to release site clearance in IHCs.
This article has an associated First Person interview with the first author of the paper.
Assessment of factors influencing oral health-related quality of life (OHRQoL) of patients with removable dental prosthesis
Authors: Deeb Modhi Al , Abduljabbar Tariq , Vohra Fahim , Zafar Muhammad S , Hussain Mudassir A. 
Published: December 2019

Objective: The aim of this study was to evaluate factors affecting oral health related quality of life (OHRQoL) of patients using removable dental prosthesis.
Methods: The present study employed a cross sectional analytical design. A total of 200 patients participated and interviewed using a cross sectional analytical design. In the first section of the questionnaire patients were asked about demographic data whereas the second part of the questionnaire assessed medical history, oral habits, smoking status, oral hygiene habits and frequency of dental visit. The questionnaire also collected information regarding patient’s removable prosthesis. Questionnaire of OHIP-DENT (Oral Health Impact Profile) was also employed to measure oral health quality of life (OHRQoL) on the domains of functional limitation (FL), physical pain (P1), psychological discomfort (P2), physical disability (D1), psychological disability (D2), social disability (D3) and handicap (H). Relationships between the demographic, socio-economic and education variables and others OHIP-EDENT scores were explored by comparing mean scores by applying ANOVA
Results: The study participants comprised of 107 males (53.5%) and 93 females (46.5%). Regarding oral care, participants reporting to visit their dentist within one year were 40.0%. The highest score was recorded for the functional limitation (FL) domain (15.62±6.6), followed by social disability (D3) (15.23±5.06) and physical pain (P1) (14.28±4.8). The respective scores for physical (D1) and psychological disability (D2) and handicap (H) were 10.47±4.84, 11.32±5.38 and 12.45±4.50 respectively.
Conclusions: Removable partial denture patients showed minimum problems with mastication, social compromise and functional discomfort. The oral health quality of life of removable denture patients is significantly influenced by patient education level, socio-economic status, medical conditions, smoking and tobacco use habits.
doi: https://doi.org/10.12669/pjms.36.2.1257
How to cite this:Al-Deeb M, Abduljabbar T, Vohra F, Zafar MS, Hussain M. Assessment of factors influencing oral health-related quality of life (OHRQoL) of patients with removable dental prosthesis. Pak J Med Sci. 2020;36(2):213-218. doi: https://doi.org/10.12669/pjms.36.2.1257
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pain perception of orthodontic treatment – A cross-sectional study
Authors: Jawaid Mazia , Ahsan Qadeer Tabassum , Fahim Muhammad Faisal 
Published: December 2019

Objectives: The objectives were to evaluate the intensity of pain perceived 24 hours following insertion of fixed orthodontic appliance components i-e separators, bands and brackets.
Methods: This cross-sectional study conducted at a Dental College in Karachi (July 2017-March 2018) investigated the amount of pain perceived during different stages of fixed orthodontic treatment. The inclusion criteria were healthy individuals without systemic disease, age 13-26 years, fixed orthodontic treatment candidates having healthy permanent first molars. The exclusion criteria were missing permanent first molars, patients requiring brass wire separators instead of elastomeric separators and molar tubes instead of bands, ongoing or previous periodontal disease and syndromic patients. Pain intensity was assessed in ninety eight patients using a Numeric Rating scale (NRS) at baseline (T0) before insertion, and 24 hours after insertion (T1) of a component. This procedure was repeated six times, twice each for separators, bands and brackets. Scoring was done on the NRS from 0 to 10 where 0 indicated no pain and 10 indicated worst pain possible.
Results: A significant difference in perceived pain was found between baseline and after 24 hours of placement of all components (P-value 0.000). Odds ratio indicated that males were at a greater risk to feel pain than females at baseline and after 24 hours of insertion of all components. Mann-Whitney U test showed that the most painful components at baseline were bands (Mean value=0.56) and after 24 hours were brackets (Mean value 6.25).
Conclusions: Significant increase in pain was noted 24 hours after insertion of separators, bands and brackets. The most painful components were bands at baseline and brackets after 24 hours of insertion. There were no significant variations in pain perception based on age. However, males perceived higher pain than females both at baseline and after 24 hours.
doi: https://doi.org/10.12669/pjms.36.2.619
How to cite this:Jawaid M, Qadeer TA, Fahim MF. Pain perception of orthodontic treatment – A cross-sectional study. Pak J Med Sci. 2020;36(2):160-165. doi: https://doi.org/10.12669/pjms.36.2.619
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comparison of neck length, relative neck length and height with incidence of cervical spondylosis
Authors: Ahmed Syeda Bushra , Qamar Aisha , Imran Muhammad , Fahim Muhammad Faisal 
Published: December 2019

Objective: To compare the neck length, relative neck length and height between patients with cervical spondylosis and healthy subjects.
Methods: This case control study was conducted at Patel hospital, Karachi after the ethical approval of Bahria University Medical and Dental College (BUMDC) and Patel hospital from September 2018 - February 2019. It enrolled eighty eight cases of cervical spondylosis and eighty eight healthy subjects. Radiographs were taken in the lateral view and neck length was measured as the distance from external occipital protuberance to seventh cervical vertebra spinous process. Then relative neck length was measured by dividing the neck length with height and multiplying it by 100. The Kellgren Lawrence grade scale was used to assess the severity of cervical spondylosis.
Results: A total of 176 participants were analyzed. It was found that the height remains the significant determinant. The comparison of cases with control group was done using independent T-test which showed that the cases were significantly shorter than controls with a p-value < 0.05. The other variables such as neck length, and relative neck length were insignificant.
Conclusion: Short height can be considered as a risk factor for cervical spondylosis. Short-statured individuals should be counseled to adopt measures for the prevention of cervical spondylosis.
doi: https://doi.org/10.12669/pjms.36.2.832
How to cite this:Ahmed SB, Qamar A, Imram M, Fahim MF. Comparison of neck length, relative neck length and height with incidence of cervical spondylosis. Pak J Med Sci. 2020;36(2):219-223. doi: https://doi.org/10.12669/pjms.36.2.832
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile
Authors: Lawlor Deborah A. , Lewcock Melanie , Rena-Jones Louise , Rollings Claire , Yip Vikki , Smith Daniel , Pearson Rebecca M. , Johnson Laura , Millard Louise A. C. , Patel Nashita , Skinner Andy , Tilling Kate ,   ALSPAC Executive
Published: December 2019

Background: The Avon Longitudinal Study of Parents and Children-Generation 2 (ALSPAC-G2) was set up to provide a unique multi-generational cohort. It builds on the existing ALSPAC resource, which recruited 14,541 pregnancies to women resident in the South West of England who were expected to deliver between 01/04/1991 and 31/12/1992. Those women and their partners (Generation 0; ALSPAC-G0) and their offspring (ALSPAC-G1) have been followed for the last 27 years. This profile describes recruitment and data collection on the next generation (ALSPAC-G2)—the grandchildren of ALSPAC-G0 and children of ALSPAC-G1. Recruitment: Recruitment began on the 6 th of June 2012 and we present details of recruitment and participants up to 30 th June 2018 (~6 years). We knew at the start of recruitment that some ALSPAC-G1 participants had already become parents and ALSPAC-G2 is an open cohort; we recruit at any age. We hope to continue recruiting until all ALSPAC-G1 participants have completed their families. Up to 30 th June 2018 we recruited 810 ALSPAC-G2 participants from 548 families. Of these 810, 389 (48%) were recruited during their mother’s pregnancy, 287 (35%) before age 3 years, 104 (13%) between 3-6 years and 30 (4%) after 6 years. Over 70% of those invited to early pregnancy, late pregnancy, second week of life, 6-, 12- and 24-month assessments (whether for their recruitment, or a follow-up, visit) have attended, with attendance being over 60% for subsequent visits up to 7 years (too few are eligible for the 9- and 11-year assessments to analyse). Data collection: We collect a wide-range of socioeconomic, lifestyle, clinical, anthropometric and biological data on all family members repeatedly. Biological samples include blood (including cord-blood), urine, meconium and faeces, and placental tissue. In subgroups detailed data collection, such as continuous glucose monitoring and videos of parent-child interactions, are being collected.
A EDUCAÇÃO ENTRE A RELIGIÃO E A POLÍTICA: CONSERVADORISMO CRISTÃO E O HOMESCHOOLING.
Authors: Da Cruz Alves Junior Alexandre Guilherme , Vilas-Bôas Trovão Flávio 
Published: December 2019

O presente ensaio tem poro objetivo discorrer sobre a construção dos argumentos religiosos nos Estados Unidos para a defesa da implementação e popularização do homeschooling como modalidade de educação formal. Embora os argumentos dos seus defensores não se resumam aos aspectos religiosos, interessa-nos compreender a sua apropriação como um espaço de mediação entre tais valores e a política educacional institucional, resgatando o contexto histórico norte-americano dos anos 1980, no momento de sua expansão e suas possíveis variações na atual política educacional daquele país. .
Design and Test of a Pineapple Picking End-effector
Authors: Du Xinwu , Yang Xulong , Ji Jiangtao , Jin Xin , Chen Lei 
Published: December 2019

Abstract. In eastern China, pineapple harvesting is a complicated and sometimes dangerous task, and an effective method to harvest pineapples instead of picking them manually has not been developed. In this article, a pineapple picking end-effector based on the physical properties of pineapples (static friction characteristics and compressive properties) was designed. The fingers of the end-effector were used to capture a pineapple in the form of step-by-step movement to help reduce fruit damage and plant damage during picking. The indexes of the evaluation of the pineapple picking performance (fruit damage rate, plant damage rate, fruit fall rate and average picking time) were established, and the picking test was conducted at a pineapple plantation. The temperature effect was analyzed in the morning (19°C) and at noon (35°C). The temperature had no significant effect on the picking performance. The picking performance test showed that the size of the fruit might be the main cause of fruit damage. Throughout the picking test, the fruit damage rate was 5%, the plant damage rate was 0%, the fruit fall rate was 1.7%, and the average picking time of each fruit was 14.9 s. Keywords: Pineapple, Physical properties, End-effector, Low damage picking.