bluuebunny/crossref_metadata_2025_split huggingface dataset:
The French eHealth Acceptability Scale Using the Unified Theory of Acceptance and Use of Technology 2 Model: Instrument Validation Study
Authors: Hayotte Meggy , Thérouanne Pierre , Gray Laura , Corrion Karine , d'Arripe-Longueville Fabienne 
Published: April 2020

BackgroundTechnology-based physical activity suggests new opportunities for public health initiatives. Yet only 45% of technology interventions are theoretically based, and the acceptability mechanisms have been insufficiently studied. Acceptability and acceptance theories have provided interesting insights, particularly the unified theory of acceptance and use of technology 2 (UTAUT2). In several studies, the psychometric qualities of acceptability scales have not been well demonstrated.ObjectiveThe aim of this study was to adapt the UTAUT2 to the electronic health (eHealth) context and provide a preliminary validation of the eHealth acceptability scale in a French sample.MethodsIn line with the reference validation methodologies, we carried out the following stages of validating the scale with a total of 576 volunteers: translation and adaptation, dimensionality tests, reliability tests, and construct validity tests. We used confirmatory factor analysis to validate a 22-item instrument with 7 subscales: Performance Expectancy, Effort Expectancy, Social Influence, Facilitating Conditions, Hedonic Motivation, Price Value, and Habit.ResultsThe dimensionality tests showed that the bifactor confirmatory model presented the best fit indexes: χ2173=434.86 (P<.001), χ2/df=2.51, comparative fit index=.97, Tucker-Lewis index=.95, and root mean square error of approximation=.053 (90% CI .047-.059). The invariance tests of the eHealth acceptability factor structure by sex demonstrated no significant differences between models, except for the strict model. The partial strict model demonstrated no difference from the strong model. Cronbach alphas ranged from .77 to .95 for the 7 factors. We measured the internal reliability with a 4-week interval. The intraclass correlation coefficients for each subscale ranged from .62 to .88, and there were no significant differences in the t tests from time 1 to time 2. Assessments for convergent validity demonstrated that the eHealth acceptability constructs were significantly and positively related to behavioral intention, usage, and constructs from the technology acceptance model and the theory of planned behavior.ConclusionsThe 22-item French-language eHealth acceptability scale, divided into 7 subscales, showed good psychometric qualities. This scale is thus a valid and reliable tool to assess the acceptability of eHealth technology in French-speaking samples and offers promising avenues in research, clinical practice, and marketing.
Age-Associated Capacity to Progress When Playing Cognitive Mobile Games: Ecological Retrospective Observational Study
Authors: Bonnechère Bruno , Bier Jean-Christophe , Van Hove Olivier , Sheldon Sally , Samadoulougou Sékou , Kirakoya-Samadoulougou Fati , Klass Malgorzata 
Published: April 2020

Background
The decline of cognitive function is an important issue related to aging. Over the last few years, numerous mobile apps have been developed to challenge the brain with cognitive exercises; however, little is currently known about how age influences capacity for performance improvement when playing cognitive mobile games.

Objective
The objective of this study was to analyze the score data of cognitive mobile games over a period of 100 gaming sessions to determine age-related learning ability for new cognitive tasks by measuring the level of score improvement achieved by participants of different ages.

Methods
Scores from 9000 individuals of different ages for 7 cognitive mobile games over 100 gaming sessions were analyzed. Scores from the first session were compared between age groups using one-way analysis of variance. Mixed models were subsequently used to investigate the progression of scores over 100 sessions.

Results
Statistically significant differences were found between age groups for the initial scores of 6 of the 7 games (linear trend, P<.001). Cognitive mobile game scores increased for all participants (P<.001) suggesting that all participants were able to improve their performance. The rate of improvement was, however, strongly influenced by the age of the participant with slower progression for older participants (P<.001).

Conclusions
This study provides evidence to support two interesting insights—cognitive mobile game scores appear to be sensitive to the changes in cognitive ability that occur with advancing age; therefore, these games could be a convenient way to monitor cognitive function over long-term follow-up, and users who train with the cognitive mobile games improve regardless of age.
Quality of Information Regarding Repair Restorations on Dentist Websites: Systematic Search and Analysis
Authors: Kanzow Philipp , Büttcher Amelie Friederike , Wiegand Annette , Schwendicke Falk 
Published: April 2020

BackgroundRepairing instead of replacing partially defective dental restorations represents a minimally invasive treatment concept, and repairs are associated with advantages over complete restoration replacement. To participate in the shared decision-making process when facing partially defective restorations, patients need to be aware of the indications, limitations, and advantages or disadvantages of repairs. Patients are increasingly using the internet to gain health information like this online.ObjectiveWe aimed to assess the quality of German-speaking dentist websites on repairs of partially defective restorations.MethodsThree electronic search engines were used to identify German-speaking websites of dental practices mentioning repairs. Regarding information on repairs, websites were assessed for (1) technical and functional aspects, (2) comprehensiveness of information, and (3) generic quality and risk of bias. Domains 1 and 3 were scored using validated tools (LIDA and DISCERN). Comprehensiveness was assessed using a criterion checklist related to evidence, advantages and disadvantages, restorations and defects suitable for repairs, and information regarding technical implementation. Generalized linear modeling was used to assess the impact of practice-specific parameters (practice location, practice setting, dental society membership, and year of examination or license to practice dentistry) on the quality of information. An overall quality score was calculated by averaging the quality scores of all three domains and used as primary outcome parameter. Quality scores of all three domains were also assessed individually and used as secondary outcomes.ResultsFifty websites were included. The median score of quality of information was 23.2% (interquartile range [IQR] 21.7%-26.2%). Technical and functional aspects (55.2% [IQR 51.7%-58.6%]) showed significantly higher quality than comprehensiveness of information (8.3% [IQR 8.3%-16.7%]) and generic quality and risk of bias (3.6% [IQR 0.0%-7.1%]; P<.001/Wilcoxon). Quality scores were not related to practice-specific parameters (P>.05/generalized linear modeling).ConclusionsThe quality of German-speaking dentist websites on repairs was limited. Despite sufficient technical and functional quality, the provided information was neither comprehensive nor trustworthy. There is great need to improve the quality of information to fully and reliably inform patients, thereby allowing shared decision making.
Implementasi Strategi Pengendalian Alur Laut Kepulauan Indonesia (ALKI) II Dalam Mendukung Ketahanan Nasional
Authors: Hidayat Abdiyan Syaiful 
Published: April 2020

AbstractThe Republic of Indonesia has ratified the United Nations Convention on the Law of the Sea 1982 (UNCLOS 82) through the Indonesian Law No. 17 of 1985 dated 13 December 1985, which was in force on 16 November 1994. As a result, Indonesia has established three archipelagic sea lanes, or otherwise known as ALKI (North-South), namely ALKI I, ALKI II and ALKI III. ALKI III has a three-pronged Southern points IIIA, IIIB and IIIC. With this establishment, Indonesia as the archipelagic state must be capable of ensuring safe passage of shipping through these lanes, while at the same time capable of enforcing its sovereignty over the related waters. The purpose of this study is to analyze the various determinant factors which affects the Indonesian Navy’s Second Fleet Command’s success in implementing sea control strategy within ALKI II which falls into its area of operations. These factors are tactics and procedures, weaponry capability, sensors capability, exercise and operational effectiveness. The research was conducted using mixed research methods. The determinant factor will be established in a statistic model which named Structural Equation Modeling which uses the Linear Structural Relationship (Lisrel) software version 8,70. Qualitative analysis was conducted using the Soft System Methodology (SSM). The end results of this research concluded that all of the determinant factors would affect the Second Fleet Command’s ability to implement and execute the sea control strategy successfully. AbstrakIndonesia telah meratifikasi United Nation Convention on The Law of The Sea 1982 (UNCLOS 1982) melalui Undang-undang Nomor 17 Tahun 1985 tanggal 13 Desember 1985 dan mulai berlaku pada tanggal 16 November 1994. Sebagai konsekuensinya Indonesia menetapkan tiga jalur Alur Laut Kelpulauan Indonesia (ALKI) Utara-Selatan, yaitu ALKI I, ALKI II dan ALKI III dengan tiga cabang titik Selatan III A, III B, III C. Untuk itu Indonesia harus dapat menjamin keamanan pelayaran di sepanjang ALKI dan menegakkan kedaulatan. Tujuan dari penelitian ini untuk mengidentifikasi dan memodelkan faktor-faktor yang mempengaruhi keberhasilan Komando Armada (Koarmada) II dalam mengimplementasikan strategi pengendalian laut di ALKI II. Faktor-faktor yang digunakan dalam penelitian ini adalah penguasaan taktik dan prosedur, kemampuan persenjataan, kemampuan sensor dan latihan untuk meningkatkan efektifitas operasi. Penelitian menggunakan metode penelitian campuran. Pemodelan faktor-faktor dilakukan dengan metode Structural Equation Modeling (SEM) dengan software Lisrel versi 8,70. Analisis data kualitatif menggunakan metode Soft System Methodology (SSM). Hasil penelitian ini menyimpulkan bahwa faktor-faktor yang disebut di atas sangat mempengaruhi keberhasilan Koarmada II dalam mengimplementasikan strategi pengendalian laut di ALKI II.
Enseñanza de la validación de métodos analíticos: protocolos experimentales de química forense
Authors: Gavilán García Irma Cruz , López Santiago Norma Ruth 
Published: April 2020

<p>En este trabajo es presenta una propuesta de protocolos experimentales en el contexto de la Química Forense como proyectos para el desarrollo y validación de métodos analíticos, en los que se abordaron de forma adicional aspectos integradores de la carrera de química y de la aplicación de los mismos a situaciones plausibles en la realidad, para resaltar la importancia de la generación de resultados confiables que soporten la controversia jurídica. El proceso de enseñanza y aprendizaje se alcanza, ya que al final el estudiante es capaz de obtener los parámetros de validación para el tipo de pruebas cualitativas que se establecen en lo protocolos propuestos.</p>
Cooperación académica: Universidad y sector productivo regional
Authors: Eslava-Zapata Rolando , Chacón-Lobo Genny , Chacón-Guerrero Édixon , Gonzalez-Júnior Hilário Alonso 
Published: April 2020

El presente artículo tiene como propósito plantear los factores que influyen en el fortalecimiento de la cooperación académica entre la Universidad y el sector productivo regional durante el proceso de las pasantías universitarias. En tal contexto, este documento se define como un estudio de tipo descriptivo documental que procura el aporte de elementos de reflexión con respecto a la estructura económica actual y la necesaria transferencia de conocimientos por parte de los egresados universitarios a la sociedad. En este sentido, se pudo concluir que la relación sector productivo-Universidad se hace hoy prioritaria, pues de allí depende el desarrollo de la capacidad científica y tecnológica de un país. En efecto, la renovación y actualización del recurso humano con habilidades y conocimientos científicos representa la base para intervenir en una sociedad cada día más exigente y con una economía altamente competitiva. Por tanto, el binomio academia – empresa construye el fundamento teórico práctico pertinente para sustentar la relación desde el punto de vista económico, social, político, cultural y educativo en el proceso de democratización del conocimiento científico y tecnológico.
Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes
Authors: Hartman Mark L. , Sanyal Arun J. , Loomba Rohit , Wilson Jonathan M. , Nikooienejad Amir , Bray Ross , Karanikas Chrisanthi A. , Duffin Kevin L. , Robins Deborah A. , Haupt Axel 
Published: April 2020

OBJECTIVE
To determine the effect of tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptors, on biomarkers of nonalcoholic steatohepatitis (NASH) and fibrosis in patients with type 2 diabetes mellitus (T2DM).

RESEARCH DESIGN AND METHODS
Patients with T2DM received either once weekly tirzepatide (1, 5, 10, or 15 mg), dulaglutide (1.5 mg), or placebo for 26 weeks. Changes from baseline in alanine aminotransferase (ALT), aspartate aminotransferase (AST), keratin-18 (K-18), procollagen III (Pro-C3), and adiponectin were analyzed in a modified intention-to-treat population.

RESULTS
Significant (P &lt; 0.05) reductions from baseline in ALT (all groups), AST (all groups except tirzepatide 10 mg), K-18 (tirzepatide 5, 10, 15 mg), and Pro-C3 (tirzepatide 15 mg) were observed at 26 weeks. Decreases with tirzepatide were significant compared with placebo for K-18 (10 mg) and Pro-C3 (15 mg) and with dulaglutide for ALT (10, 15 mg). Adiponectin significantly increased from baseline with tirzepatide compared with placebo (10, 15 mg).

CONCLUSIONS
In post hoc analyses, higher tirzepatide doses significantly decreased NASH-related biomarkers and increased adiponectin in patients with T2DM.
Wilson Disease With Novel Compound Heterozygote Mutations in the ATP7B Gene Presenting With Severe Diabetes
Authors: Li Juyi , Jiang Yanli , Xu Teng , Zhang Yao , Xue Jiajia , Gao Xiao , Yang Xiaoyan , Wang Xiufang , Jia Xiong , Cheng Wenzhuo , Jin Si 
Published: April 2020

OBJECTIVE
To determine the relationship between ATP7B mutations and diabetes in Wilson disease (WD).

RESEARCH DESIGN AND METHODS
A total of 21 exons and exon-intron boundaries of ATP7B were identified by Sanger sequencing.

RESULTS
Two novel compound heterozygous mutations (c.525 dupA/ Val176Serfs*28 and c.2930 C&gt;T/ p.Thr977Met) were detected in ATP7B. After d-penicillamine (D-PCA) therapy, serum aminotransferase and ceruloplasmin levels in this patient were normalized and levels of HbA1c decreased. However, when the patient ceased to use D-PCA due to an itchy skin, serum levels of fasting blood glucose increased. Dimercaptosuccinic acid capsules were prescribed and memory recovered to some extent, which was accompanied by decreased insulin dosage for glucose control by 5 units.

CONCLUSIONS
This is the first report of diabetes caused by WD.
Metabolic Factors, Lifestyle Habits, and Possible Polyneuropathy in Early Type 2 Diabetes: A Nationwide Study of 5,249 Patients in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Cohort
Authors: Christensen Diana H. , Knudsen Søren T. , Gylfadottir Sandra S. , Christensen Lotte B. , Nielsen Jens S. , Beck-Nielsen Henning , Sørensen Henrik T. , Andersen Henning , Callaghan Brian C. , Feldman Eva L. , Finnerup Nanna B. , Jensen Troels S. , Thomsen Reimar W. 
Published: April 2020

OBJECTIVE
To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes.

RESEARCH DESIGN AND METHODS
We thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2.8 years, we sent a detailed questionnaire on neuropathy, including the Michigan Neuropathy Screening Instrument questionnaire (MNSIq), to identify possible DPN (score ≥4) and the Douleur Neuropathique en 4 Questions (DN4) questionnaire for possible associated neuropathic pain (MNSIq ≥4 + pain in both feet + DN4 score ≥3).

RESULTS
Among 5,249 patients with data on both DPN and pain, 17.9% (n = 938) had possible DPN, including 7.4% (n = 386) with possible neuropathic pain. In regression analyses, central obesity (waist circumference, waist-to-hip ratio, and waist-to-height ratio) was markedly associated with DPN. Other important metabolic factors associated with DPN included hypertriglyceridemia ≥1.7 mmol/L, adjusted prevalence ratio (aPR) 1.36 (95% CI 1.17; 1.59); decreased HDL cholesterol &lt;1.0/1.2 mmol/L (male/female), aPR 1.35 (95% CI 1.12; 1.62); hs-CRP ≥3.0 mg/L, aPR 1.66 (95% CI 1.42; 1.94); C-peptide ≥1,550 pmol/L, aPR 1.72 (95% CI 1.43; 2.07); HbA1c ≥78 mmol/mol, aPR 1.42 (95% CI 1.06; 1.88); and antihypertensive drug use, aPR 1.34 (95% CI 1.16; 1.55). Smoking, aPR 1.50 (95% CI 1.24; 1.81), and lack of physical activity (0 vs. ≥3 days/week), aPR 1.61 (95% CI 1.39; 1.85), were also associated with DPN. Smoking, high alcohol intake, and failure to increase activity after diabetes diagnosis associated with neuropathic pain.

CONCLUSIONS
Possible DPN was associated with metabolic syndrome factors, insulin resistance, inflammation, and modifiable lifestyle habits in early type 2 diabetes.
Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial
Authors: Watada Hirotaka , Takami Akane , Spranger Robert , Amano Atsushi , Hashimoto Yasuhiro , Niemoeller Elisabeth 
Published: April 2020

OBJECTIVE
To assess the efficacy and safety of a 1:1 fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) versus lixisenatide (Lixi) in insulin-naive Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drugs (OADs).

RESEARCH DESIGN AND METHODS
In this phase 3, open-label, multicenter trial, 321 patients with HbA1c≥7.5 to ≤10.0% (58–86 mmol/mol) and fasting plasma glucose (FPG) ≤13.8 mmol/L (250 mg/dL) were randomized 1:1 to iGlarLixi or Lixi for 52 weeks. The primary end point was change in HbA1c at week 26.

RESULTS
Change in HbA1c from baseline to week 26 was significantly greater with iGlarLixi (−1.58% [−17.3 mmol/mol]) than with Lixi (−0.51% [−5.6 mmol/mol]), confirming the superiority of iGlarLixi (least squares [LS] mean difference −1.07% [−11.7 mmol/mol], P &lt; 0.0001). At week 26, significantly greater proportions of patients treated with iGlarLixi reached HbA1c &lt;7% (53 mmol/mol) (65.2% vs. 19.4%; P &lt; 0.0001), and FPG reductions were greater with iGlarLixi than Lixi (LS mean difference −2.29 mmol/L [−41.23 mg/dL], P &lt; 0.0001). Incidence of documented symptomatic hypoglycemia (≤3.9 mmol/L [70 mg/dL]) was higher with iGlarLixi (13.0% vs. 2.5%) through week 26, with no severe hypoglycemic events in either group. Incidence of gastrointestinal events through week 52 was lower with iGlarLixi (36.0% vs. 50.0%), and rates of treatment-emergent adverse events were similar.

CONCLUSIONS
This phase 3 study demonstrated superior glycemic control and fewer gastrointestinal adverse events with iGlarLixi than with Lixi, which may support it as a new treatment option for Japanese patients with T2DM that is inadequately controlled with OADs.
Adaptation Proposed Methods for Handling Imbalanced Datasets based on Over-Sampling Technique
Authors: Shoohi Liqaa M. , Saud Jamila H. 
Published: April 2020

Classification of imbalanced data is an important issue. Many algorithms have been developed for classification, such as Back Propagation (BP) neural networks, decision tree, Bayesian networks etc., and have been used repeatedly in many fields. These algorithms speak of the problem of imbalanced data, where there are situations that belong to more classes than others. Imbalanced data result in poor performance and bias to a class without other classes. In this paper, we proposed three techniques based on the Over-Sampling (O.S.) technique for processing imbalanced dataset and redistributing it and converting it into balanced dataset. These techniques are (Improved Synthetic Minority Over-Sampling Technique (Improved SMOTE), Borderline-SMOTE + Imbalanced Ratio(IR), Adaptive Synthetic Sampling (ADASYN) +IR) Algorithm, where the work these techniques are generate the synthetic samples for the minority class to achieve balance between minority and majority classes and then calculate the IR between classes of minority and majority. Experimental results show ImprovedSMOTE algorithm outperform the Borderline-SMOTE + IR and ADASYN + IR algorithms because it achieves a high balance between minority and majority classes.
PESQUISADOR DIGITAL: ANÁLISE DE COMPETÊNCIAS E REALIDADE BIBLIOMÉTRICA
Authors: Fukunaga Fernando , Rosa Dias Julio , Ferreira Mariana , Trevisan Leonardo , Marangoni Matheus 
Published: April 2020

O objetivo deste estudo foi contribuir para aumento da estrutura de conhecimento do campo de gestão de carreira do pesquisador das ciências sociais aplicadas atuante no contexto da pesquisa na era digital, mapeando e identificando as novas competências requeridas, as práticas vivenciadas e as ferramentas digitais utilizadas nas diversas etapas do processo de pesquisa acadêmica. Foi realizada uma revisão sistemática da literatura no campo da pesquisa na era digital, no período de 2013 a 2018. Os resultados refletem três categorias: um conjunto de novas competências hard e soft para o pesquisador digital emanadas das diversas variáveis da era digital, um conjunto de práticas colaborativas e de interação antes desconhecidas pela pesquisa tradicional, e um conjunto de ferramentas digitais que apoiam as práticas e o processo de pesquisa na era digital e finalmente estratégias para desenvolvimento e aplicação de competências, práticas e ferramentas digitais pelos pesquisadores. Pesquisador digital está apenas nascendo, há campo vasto para ser explorado no que tende a sua carreira e competências e como ele faz uso das ferramentas digitais e da colaboração para produzir conhecimento relevante.