bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Outcomes of Sexual and Gender Minorities After Cancer: A Scoping Review
Authors: Pratt-Chapman Mandi , Rodriguez-Diaz Carlos E. , Alpert Ash 
Published: October 2020

Abstract
Purpose: Cancer research on sexual and gender minority (SGM) populations is gaining momentum. However, literature on patient-reported health outcomes for SGM people with a history of cancer is limited. The purpose of this review was to examine the nature and extent of research regarding patient-reported health outcomes after cancer treatment among SGM populations. Methods: A systematic search of key words, titles, abstracts, and/or major subjects was conducted in PubMed, Scopus, and CINAHL in September 2019 and in EMBASE in February 2020. Included studies investigated at least one physical, psychosocial, emotional, or functional patient-reported outcome related to cancer diagnosis and/or treatment. Articles that met inclusion criteria were reviewed in their entirety, charted in a Word Table, assessed for quality, and trends within and across studies were reported in addition to each study’s results. Results: Fifty-two studies were included in the final analysis; most were quantitative and focused on people with a history of breast and prostate cancer. Most studies were secondary analyses or cross-sectional studies of convenience samples, limiting generalizability. Conclusions: A growing literature describes the patient-reported health outcomes of SGM people with a history of cancer. This study summarizes important between-group differences among SGM and heterosexual, cisgender counterparts that are critical for clinicians to consider when providing care. Implications for cancer survivors: Sexual orientation and gender identity are relevant to cancer survivors’ health outcomes. Clinicians and researchers can build an evidence base to inform care improvements by collecting data on anatomy, sexual orientation, and gender identity in Electronic Health Records and population-based surveys.
Finite Element Analysis of Necessity of Reduction and Selection of Internal Fixation for Valgus-impacted Femoral Neck Fracture
Authors: Dai Yahui , Ni Ming , Dou Bang , Wang Zhiyuan , Zhang Yushan , Cui Xueliang , Ma Wenqian , Qin Tao , Xu Xiaobin , Mei Jiong 
Published: October 2020

Abstract
BackgroundAlthough valgus-impacted fractures don’t displace obviously, a larger valgus angle and posterior tilt of the femoral head can cause hip joint dysfunction and femoral head necrosis. The optimal surgical approach for valgus-impacted femoral neck fractures remains controversial. This study compared the biomechanical characteristics of different treatment strategies based on finite element analysis.MethodsTen valgus-impacted femoral neck fractures were analyzed in terms of posterior tilt and valgus angle measured on X-ray radiographs. Using these data, we generated 7 finite element models that were compared in terms of von Mises stress distribution and displacement.ResultsIn the intact femur, von Mises stress was concentrated at the medial and inferior sides of the femoral neck. In valgus-impacted femoral neck fractures, von Mises stress was at the same locations but was 5.66 times higher than that in the intact femur. When 3 cannulated screws were used for internal fixation, anatomic reduction diminished the stress at the fracture end from 140.6 to 59.14 MPa, although displacement increased from 0.228 to 0.450 mm. When the fracture was fixed with a sliding hip screw (SHS) + cannulated screw, there was less stress at the fracture end and greater displacement with anatomic reduction than that without reduction (stress: 15.9 vs 37.9 MPa; displacement: 0.329 vs 0.168 mm).ConclusionsThe SHS + cannulated screw has superior biomechanical stability than 3 cannulated screws, and is recommended following anatomic reduction to treat valgus-compacted femoral neck fractures.
Retrospective Analysis of Traumatic Triradiate Cartilage Injury&nbsp;in Children
Authors: Dong Yao , Wang Jinkui , Qin Jiaqiang , Nan Guoxin , Su Yuxi , He Bo , Cai Wenquan , Chen Kai , Gu Kai , Liang Xun , Yan Ge , Wang Zhongliang 
Published: October 2020

Abstract
Background: To summarize and analyze the epidemiological characteristics, treatment and corresponding curative effect of triradiate cartilage injury(TCI) in children after trauma, to provide a theoretical basis for early diagnosis and improvement of treatment. Methods: The TCI was classified according to our modified Bucholz classification (type IV and VI were added), and the final curative effect was evaluated with Harris Hip Score and imaging examination during follow-up. Finally, a comprehensive analysis was made by reviewing the cases in the literature combined with the patients in our hospital. Results: A total of 15 cases (18 hips) of triradiate cartilage injuries were collected in our hospital. There was one hip with type I injury, nine hips with type II injury, two hips with type IV injury, one hip with type V injury and five hips with type VI injury. Among the 12 cases with complete follow-up, the bone bridge was found in or around the triradiate cartilage in 8 cases，early fusion of triradiate cartilage occurred in 5 patients, 3 cases had hip dysplasia, 4 cases had a subluxation of the femoral head, and HHS was excellent in 8 cases and good in 4 cases.Conclusion: The early diagnosis of TCI is still a quite challenging issue. Conservative treatment is often the first choice. The overall prognosis of acetabular fractures involving triradiate cartilage is poor. The formation of the bone bridge in triradiate cartilage usually indicates the possibility of premature closure, which may lead to acetabular dysplasia. Level of evidence IV: Retrospective case series
The Transfer Paths’ Contribution Analysis to Floor Vibration of Metro Vehicle
Authors: laixian peng , Nie Jiaxing , Han Jian , Mi Caiying 
Published: October 2020

Abstract
Noise control is one of key issues to improve the ride comfort of metro trains. To find out the excitation source and its transfer path is an important prerequisite for noise control. The sound source identification results found that the significant noise source in metro trains is the structural-borne sound radiated by floor vibration. Based on the OTPA method, this study presents a method considering the amplitude and phase of the excitation to analyze the contribution of the secondary suspension path to the floor vibration. The results show that the energy of the passenger room noise mainly concentrates on the frequency range of 300~800Hz, caused by floor vibration; in the frequency range of 300~800Hz, the vertical direction of the anti-rolling torsion bar area provides the maximum contribution to the floor vibration, followed by the longitudinal direction of the air spring area. On the basis of contribution analysis, a transfer path optimization scheme is proposed, which may provide reference for future metro trains noise control.
Method for diagnosing the ICE cylinder-piston group in the combustion chamber in the mode of cranking the engine crankshaft
Authors: Gritsenko Alexandr , Shepelev Vladimir , Baryshnikov Sergey 
Published: October 2020

Abstract
To increase the diagnostic efficiency, significantly reduce the unproductive time, and mainly increase the reliability and accuracy, we propose a new method and tools implementing it - an oscillographic method for monitoring the pressure and phase parameters during the dynamic change in the operating parameters. The proposed work is aimed at improving the internal combustion engine (ICE) performance by timely diagnosing the cylinder-piston group (CPG) and its maintenance based on the diagnostic results. The scientific novelty of the work lies in the establishment of the interconnection of the CPG parameters obtained in the test modes of the ICE operation, allowing us to justify the diagnostic modes and their limiting values; the development of diagnostic methods and tools allowing us to justify the test modes for diagnosing the ICE CPG; the experimental data, which revealed that the instantaneous pressure signal in the combustion chamber is a sensitive diagnostic sign, which reflects the technical condition of the ICE CPG and its elements; the results of the experimental studies of diagnosing the ICE CPG in test modes. The results of the experimental work were compared with the results of theoretical modeling, the convergence between them was 97–99%. The production validation of the new method demonstrated the reliability within 0.92–0.97.
SOX7 Blocks Vasculogenic Mimicry in Oral Squamous Cell Carcinoma
Authors: Hong Kyoung-Ok , Oh Kyu-Young , Yoon Hye-Jung , Swarup Neeti , Jung Minjung , Shin Ji-Ae , Kim Jung-Hwan , Chawla Kunal , Lee Jae-Il , Cho Sung-Dae , Hong Seong-Doo 
Published: October 2020

Abstract
Background: Vasculogenic mimicry (VM) is the formation of an alternative circulatory system by aggressive tumor cells. The characteristics of VM and its underlying mechanism in oral squamous cell carcinoma (OSCC) remain unclear. This study aims to determine the relationship between VM channels in OSCC tissues and clinical outcomes and to investigate the biological role of SOX7 in VM in OSCC cells.Methods: CD31/PAS double staining was performed to evaluate VM status in OSCC tissue. The relationships between VM and clinicopathological variables, and VM and SOX7 levels were analyzed. The correlation between SOX7 levels and head and Neck cancer corhorts were investigated using in silico analysis.VM channel formation assay was performed to observe VM channels in the OSCC cell lines. To investigate the role of SOX7 in VM channel formation, SOX7 was transiently over-expressed in SCC-9 cells. VM-modulating genes were identified by Western blotting.Results: We confirmed the presence of VM channels in OSCC tissue and several cell lines and found a positive correlation between VM and lymph node metastasis and patient survival in OSCC (P = 0.003). In silico analysis from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database showed that down-regulation of SOX7 expression was significantly correlated with head and neck squamous cell carcinoma (HNSCC) patient cohorts (P = 0.0187) and lymph node metastasis (P = 0.0017). We also found that the presence of VM channels in OSCC tissue was inversely associated with SOX7 expression (P = 0.020). We observed that overexpression of SOX7 impaired VM channel formation by reducing the expression of VE-cadherin, thereby inhibiting cell migration and invasion.Conclusion: These results suggest that SOX7 plays an important role in the regulation of VM channel formation and may inhibit OSCC metastasis.
CXCR4 Negatively Correlates with NKT Cell Infiltration During Gastric Precancerous Lesions Progression to Early Gastric Cancer
Authors: Jiang Xiaotao , Zhuang Kunhai , Jiang Kailin , Wen Yi , Xie Linling , Weng Senhui , Chen Xu , Nie Kechao , Zheng Zhihua , Pan Jinglin , Yan Yanhua , Liu Peng , Zheng Junhui , Huang Yuancheng , Liu Yufeng , Li Peiwu , Liu Fengbin 
Published: October 2020

Abstract
Background Immune microenvironment in gastric precancerous lesions (GPL) and early gastric cancer (EGC) still remain largely unknown. This study aims to identify key immune cells and hub genes associated with GPL progression to EGC. Methods Immune Cell Abundance Identifier (ImmuCellAI) algorithm was used to quantify the proportions of immune cells of GPL and GC samples based on gene expression profiles. Key immune cells associated with GPL progression to EGC were identified using one‐way analysis of variance (ANOVA) test and Spearman’s correlation test. Weighted gene co-expression analysis (WGCNA) and pathway enrichment were adopted to identify hub gene co-expression network and hub genes associated with the key immune cells infiltration. The pattern of key immune cells infiltration, hub genes expression and their correlation were verified in an independent GPL-EGC cohort and GC datasets.Results NKT cell was found gradually decreased during GPL progression to EGC and negatively correlated with tumorigenesis. According to WGCNA and hub genes screening, CXCR4, having a poor prognosis, increased with GPL progression, positively correlated with tumorigenesis and negatively correlated with NKT cell infiltration significantly, was identified as the real hub gene. The negative correlation between CXCR4 and NKT cell infiltration was successfully verified in an independent GPL-EGC cohort and GC datasets.Conclusion CXCR4 and NKT cell are possible to serve as biomarkers in monitoring GPL progression to EGC. Besides, CXCR4 may be involved in regulating NKT cell infiltration during GPL progression to EGC, which may provide a new immunotherapeutic target.
Evaluation of the Risk of Water Gushing（Inrush）in Aquifer of Coal Seam Roof Based on "Three Diagram Method" – a Case Study in Hu Jiahe Coal Mine,china
Authors: Hou Enke , Yao Xing , Che Xiaoyang 
Published: October 2020

Abstract
Coal seam roof inrush phenomenon is common in Jurassic coalfield in China. In order to evaluate accurately the risk of coal seam roof water inrush (CSRWI) it needs to analyze the degree of water rich degree and crack height of strata aquifer. Based on the combined weight-TOPSIS theory, this paper intends to adopt the 8 factors of aquifer thickness, lithological structure index, core adoption rate and permeability coefficient, and TDS from the three aspects of aquifer lithology, hydrology and hydrochemical characteristics. As an evaluation index of the water richness of the aquifer in the Luohe Formation, By using the method of GI method and independent weight method subjective and objective weights influencing aquifer water rich control factors are determined and then weights are coupled by differential maximization theory.Based on GIS spatial analysis technology, an evaluation model of aquifer water rich in coal seam roof aquifer was established and verified by field measured hydrological pore data.Through empirical value calculation of coal seam roof crack height and further refinement of hydraulic fracture zone spread across aquifer floor and combined with aquifer degree of water enrichment and roof cracking degree to carry out comprehensive evaluation of the risk of CSRWI. The most important factors affecting the degree of water enrichment of aquifers are lithological structure index and permeability coefficient, followed by TDS. Compared with water-rich index method, the water-rich degree of aquifer can be effectively determined based on combination weight and TOPSIS method. Moreover, subdivision of roof crack degree indicates that the development height of hydraulic fracture zone in research area is disturbed by aquifer actual disturbance; Risk assessment results indicate that high risk of water inrush lies in southwest side of research area and prevention should be strengthened when mining. This study provides a new idea for evaluating risk zoning of coal seam roof gushing (inrush) water in coal mines of Binchang.
Public Sector Radiological Resources and Utilization Patterns in the Western Cape Province of South Africa
Authors: Zyl Beulah Christina van , Barnard Michelle Monique , Fernandez Amanda , Cloete Keith , Mukosi Matodzi , Pitcher Richard Denys 
Published: October 2020

Abstract
Background There are marked disparities in radiological resources globally, particularly between metropolitan and rural populations. The World Health Organization (WHO) suggests that 90% of low- and middle-income country (LMIC) imaging needs can be addressed by one X-ray and ultrasound machine for every 50000 people. However, this figure is untested, as limited work on radiological resources and service utilization patterns globally, particularly in LMICs exists. The aim was to analyze provincial radiological service in a middle-income country. Methods An institutional review board-approved retrospective audit of radiological data for the public healthcare sector of the Western Cape Province (WCP) of South Africa (SA) for 2017, utilizing databases of the WCP Department of Health and Stats SA. We conducted population-based analyses of imaging equipment, personnel, and service utilization data for the province, metropolitan and rural areas. Results Metropolitan population density exceeds rural (1682 vs 19 people/km 2 ; 89:1). Rural imaging facilities by population are double the metropolitan (19 vs 11/10 6 people). Provincially, there are 36 X-ray and 18 ultrasound units/10 6 people. Rural X-ray (39.3 vs 33.6/10 6 people), ultrasound (24.7 vs 14.5/10 6 people) and mammography (14 vs 5 units/10 6 women > 40 years) resources exceed metropolitan by 17, 70 and 180 percent, respectively. Metropolitan personnel resources by population (n = 112 vs 53/10 6 people) and equipment unit (1.7 vs 0.7/10 6 people) are double the rural. Provincial imaging studies totalled 1.2778 million, averaging 262 examinations/10 3 people and 1.3 investigations/patient. Radiography (n=935607,73%) and ultrasound (n=202639,16%) together constituted 89% (n=1138246) of studies. Population-based utilization of imaging services was 30% higher in the metropole (279 vs 214 studies/10 3 people), with mammography (24 vs 5 studies/10 3 woman >40 years; 517%) and CT (21 vs 6/10 3 people; 380%) recording the highest differentials and plain radiography (203 vs 171/10 3 people; 19%) the lowest. Conclusion Our findings support the WHO contention that approximately ninety percent of a population’s diagnostic imaging needs can be met by plain radiography and ultrasound and underscore the complexity of achieving equitable utilization of services between rural and metropolitan areas.
Evaluating Quality Improvement at Scale: Design Considerations for Routine Reporting to Executive Board of a Healthcare Organisation in the UK National Health Service
Authors: Chua Kia-Chong , Henderson Claire , Grey Barbara , Holland Michael , Sevdalis Nick 
Published: October 2020

Abstract
BackgroundQuality improvement (QI) in healthcare is a cultural transformation process that requires long-term commitment from the executive board, a critical theme in emerging accounts of QI success in the UK National Health Service (NHS). To help sustain long-term commitment from the executive board, an organisation-wide picture of QI applications and their impact needs to be made routinely visible.MethodWe developed a retrospective evaluation drawing inputs from the resident QI team of a healthcare organisation and academic colleagues in the field of implementation and improvement science, as well as peer-reviewed and grey literature on what constitutes success for QI in healthcare. Formative feedback on content relevance, acceptability, and feasibility issues were used to guide evaluation design. The evaluation was conducted as an online survey so that the data accrual process resembles routine reporting to help surface implementation challenges. A purposive sample of QI projects was identified to maximise contrast between projects that were or were not successful as determined by the resident QI team. To hone strategic focus in what should be reported, we also compared factors that might affect project outcomes. For understanding implementation issues, we reviewed data quality to surface challenges in the design and sustainability of routine reporting for the executive board.ResultsOut of 52 QI projects, 10 led to a change in routine practice (henceforth referred to as adoption). Details of project outcomes were limited. Project team outcomes, indicative of capacity building, were not systematically documented. Service user involvement, quality of measurement plan, fidelity and documentation of plan-do-study-act (PDSA) cycles had a major impact on adoption. The proximal impact of these process factors on adoption was consistently more apparent than the distal impact of input and contextual factors.ConclusionsDesigning a routine reporting framework is an iterative process involving continual dialogue with frontline staff and improvement specialists to navigate data accrual demands. A retrospective evaluation, as in this study, can yield empirical insights for dialogue about the routine visibility of QI applications and their organisation-wide impact, thereby honing the implementation science of QI in a healthcare organisation.
Lower Risk of Death and Cardiovascular Events in Unselected Type 2 Diabetes Patients Initiated on GLP-1 Receptor Agonists and SGLT-2 Inhibitors in Two Large Italian Cohorts
Authors: Baviera Marta , Genovese Stefano , Lepore Vito , Colacioppo Pierluca , Robusto Fabio , Tettamanti Mauro , D’Ettorre Antonio , Avanzini Fausto , Fortino Ida , Nicolucci Antonio , Roncaglioni Maria Carla , Giorgino Francesco 
Published: October 2020

Abstract
Background:GLP-1 receptor agonists (G LP-1 RA) and SGLT-2 inhibitors (SGLT-2i) are recommended in type 2 diabetes subjects with established cardiovascular (CV) disease or at high CV risk. The efficacy and safety of GLP-1 RA and SGLT-2i compared with other anti-hyperglycemic agents (AHAs) was examined in large unselected populations of Lombardy and Apulia regions in Italy.Methods:An observational cohort study of new users of GLP-1 RA, SGLT-2i and other AHAs was conducted from 2010 to 2018. Death and cardiovascular events were evaluated using conditional Cox models in propensity-score matched populations. Adjusted hazard ratios (95%, CI) were calculated for each region and as meta-analysis for pooled risks.Results:After propensity-matching, the Lombardy cohort included 18,716 and 11,683 pairs and the Apulia cohort 9,772 and 6,046 pairs for the GLP-1 RA and SGLT-2i groups, respectively. Use of GLP-1 RA was associated with lower rates of death (HR 0.61, CI 0.56-0.65, Lombardy; HR 0.63, CI 0.55-0.71, Apulia), cerebrovascular disease and ischemic stroke (HR 0.70, CI 0.63-0.79; HR 0.72, CI 0.60-0.87, Lombardy) peripheral vascular disease (HR 0.72, CI 0.64-0.82, Lombardy; HR 0.80, CI 0.67-0.98, Apulia) and, lower limb complications (HR 0.67, CI 0.56-0.81, Lombardy; HR 0.69, CI 0.51-0.93, Apulia). Compared to other AHAs, SGLT-2i use decreased the risk of death (HR 0.47, CI 0.40-0.54, Lombardy; HR 0.43, CI 0.32-0.57, Apulia), cerebrovascular disease (HR 0.75, CI 0.61-0.91, Lombardy, HR 0.72, CI 0.54-0.96, Apulia), and heart failure (HR 0.56, CI 0.46-0.70, Lombardy, HR 0.57, CI 0.42-0.77, Apulia). In the pooled cohorts, a reduction in heart failure was also observed with GLP-1 RA (HR 0.89, 95% CI 0.82-0.97). Serious adverse events were quite low in frequency. Conclusions: Our findings from real world practice confirm the favorable effect of GLP-1 RA and SGLT-2i on death and CV outcomes consistent across both regions. Thus, these drug classes should be preferentially considered in a broad type 2 diabetes population beyond subjects with CV disease.