bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Participação no Fechamento de Mina no Direito Comparado
Authors: Ribeiro José Claudio Junqueira , Felisbino Mendes Samuel Santos 
Published: December 2020

A participação da sociedade civil no fechamento de minas é crucial para a garantia de uma sustentabilidade abrangente, que contemple as diferentes visões acerca da efetivação do direito ao meio ambiente ecologicamente equilibrado. Este trabalho, a partir de uma pesquisa bibliográfica e documental, tem como objetivo identificar e analisar a legislação brasileira sobre fechamento de mina, avaliando os mecanismos de participação popular nesse processo, comparando-os com as formas de participação durante o processo de licenciamento ambiental, e com as normas de outros países com liderança global na atividade minerária. O licenciamento ambiental já prevê a participação das comunidades afetadas por empreendimentos geradores de significativo impacto ambiental, por meio de audiências públicas. Entretanto, no caso da mineração, verificou-se que esses instrumentos não têm sido suficientes para garantir a sustentabilidade após o fechamento das minas, havendo necessidade de novos ordenamentos jurídicos complementares, como demonstra as experiências nacional e internacional. AbstractThe civil society participation in mine closure is crucial to guarantee a broad sustainability, one that considers the different approaches on the right to a healthy environment. This work, from a bibliographic and documental research, intends to identify and analyze the mine closure Brazilian legislation, assessing the mechanisms of popular participation in this process, comparing them with the forms of participation in the environmental licensing process and with international legislation from other countries with global leadership in mining activity. The public hearing process is already present in the environmental licensing to grant the participation of communities affected by projects generating significant environmental impact. Nonetheless, as concluded in this study, this instrument has not been successful enough in mining activities, especially concerning sustainability in mine closure. For this reason, as shown by the national and international experience, new rules are necessary to grant the participation of affected communities. KeywordsEnvironmental Licensing. Mine Closure. Participation Principle. Sustainable Development. Post Closure Sustainability.
TOWARDS A JURISPRUDENCE OF SUSTAINABILITY IN A TIME OF TRANSITION
Authors: Wade Jeffry S 
Published: December 2020

In recent decades, an increasing number of disturbing trends have prompted many scientists and policy analysts to suggest that, as a species, we may be on the verge of a major transition or turning point. Persistent negative trends in resource availability, biodiversity, environmental quality and human well-being indicate that the current global development model may be damaging Earth’s essential systems and processes beyond recovery. Environmental law, as it exists in most countries, has not succeeded in controlling the impacts and effects of this development model. A jurisprudence of sustainability is necessary, based on a set of principles that will ensure a more proactive, scientifically-based, integrated, communal and transparent approach to development regulation.
Direito ao Ambiente e o Direito à Moradia: Colisão e Ponderação de Direitos Fundamentais
Authors: Reis João Emilio de Assis 
Published: December 2020

O presente trabalho é um ensaio teórico que trata de analisar o conflito entre o direito fundamental à moradia e o direito fundamental ao meio ambiente. Partindo da análise da evolução da incorporação da tutela da moradia e do ambiente ao ordenamento jurídico como direitos, analisa a presença de ambas como direitos fundamentais na Constituição de 1988. Partindo do pressuposto de inexistência de hierarquia entre ambos os direitos, busca finalmente apresentar o método da ponderação de valores e da concordância prática, como forma de solução de conflito entre direitos fundamentais. AbstractThis paper is a theoretical rehearsal that analyzes the conflict between the fundamental right to housing and the fundamental right to the environment. Based on the analysis of the evolution of the incorporation of housing and protection of the environment in the law, analyzes the presence of both as fundamental rights in the 1988 Constitution. Assuming absence of hierarchy between both rights, search finally present the method and the weighting of practical agreement as a way of resolving conflict between fundamental rights. KeywordsConflict of Fundamental Rights. Right to Environment. Right to Housing. Urbanization.
Spiritual well-being among cancer patients and their nurses
Authors: Akbari Masoumeh , Naderi Jaleh , Jelili Shayan 
Published: December 2020

Experiences of people living with cancer have revealed that spiritual well-being is a vital aspect of a healthy life, necessary for creating a positive psychology and will guide patients toward a meaningful life. It can also increase cancer patients' adaptability and improve their quality of life and survival. The present study aimed at determining the spiritual well-being among cancer patients and their nurses. This descriptive-cross sectional study carried out with a convenience sampling method and participation of 120 hospitalized cancer patients and their nurses in oncology units. Data were collected using Paloutzian and Ellison well-being questionnaire (r = 0.82) and were analyzed using, chi-square and t-tests by using SPSS 21. The average scores of religious, existential and spiritual well-being in patients were 52, 46 and 99 respectively. Their average scores of religious, existential and spiritual well-being in nurses were 29, 40 and 70 respectively which falls within an average range (41-99). Comparing spiritual well-being scores between patients and nurses using chi-square and t- tests showed a significant difference (p=0.001). Spirituality and positive psychology have always been considered as effective treatment for people who are suffering from cancer. Increased spiritual well-being among nurses can improve spiritual health in cancer patients.

Keywords: cancer patients, spiritual well-being, religious well-being, existential well-being, positive psychology, nurses.
Exploitation of Plant Herbs in the Control of Disease Vectors: A Review
Authors: Mary Oluchi Iwuagwu  , Paschal Emeka Etusim  , Nneka Constance Emmanuel  , Jude Chibuzo Igwe  , Victor Oluoha Nwaugo  , Reginard Azu Onyeagba  
Published: December 2020

Diseases transmitted by vectors have been plaguing man since time immemorial causing millions of deaths annually. The highest occurrence reportedly occurs in tropical and subtropical areas where malaria, the commonest vector-borne disease, is highest. The management of vector-borne diseases has been basically by controlling their vectors using synthetic insecticides: the pyrethroids, organophosphates, organochlorines: carbamates. Reports have shown that these insecticides pollute the environment, result in bio-magnification and affect non-target organisms mostly man thereby raising health concern. Also, there is development of insecticide resistance in the disease vectors, which may hamper the effective use of the insecticides. These negative effects associated with the use of synthetic insecticides emphasize the need for alternative method of control. The control of disease vectors with the use of herbal-based products that have insecticidal properties is promising as it is safe to non-target organisms, eco-friendly, bio-degradable, less expensive and the development of resistance in the vectors is more or less absent. The insecticidal activity of plant herbs is attributed to the presence of complex mixture of bio-active compounds, which act as anti-feedants, oviposition deterrents, repellents, attractants, etc. Using relevant literatures, this paper discussed disease vectors, method of transmission of vector-borne diseases, the need for alternative method of disease vector control and the most common plants employed in the control of disease vectors including their families, products, bio-active compounds, their activity and mode of action. Use of plant herbs and their products can therefore, serve as alternative method for vector control programme.
Epiphyseal Angulation and Related Spatial Orientation in Slipped Capital Femoral Epiphysis
Authors: Gautier Emanuel , Passaplan Caroline , Gautier Lucienne 
Published: December 2020

Background:
The management of slipped capital femoral epiphysis (SCFE) is controversial. Surgical decision-making is based regularly on the chronicity, stability, and severity of the slip. The purpose of this study was to determine the true angulation and spatial orientation of the epiphysis in hips with SCFE and contralateral hips.

Methods:
Eighteen hips in 18 patients with SCFE were included in the analysis. Trigonometric calculations, based on angle measurements using 2 conventional radiographs in planes that are perpendicular to each other, were used to determine the angulation of the epiphysis and its orientation in space.

Results:
The mean absolute epiphyseal obliquity of the SCFE hips was 56.2° and the spatial orientation was 36.5°. The mean obliquity of the contralateral side was 34.0°, with a related spatial orientation of 16.8°. The maximum error can reach up to 9.9° (or 41%) when comparing the calculated angles with the angle measurements on radiographs.

Conclusions:
On standard radiographs, the epiphyseal angulation in SCFE is consistently underestimated. As a consequence, the assigned classification of some patients may be 1 severity group too low, which impacts the value of traditional severity classification for surgical decision-making. The analysis of the spatial orientation of the slip with the concomitant direction of the resultant shear can partially explain varus and valgus slip in SCFE.

Level of Evidence:
Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Identification of Shared Gene Signatures in Different Stages of Non-Alcoholic Fatty Liver Disease Using Integrated Microarray Dataset
Authors: Gh B. Fatemeh Nobakht M. , arabfard Masoud 
Published: December 2020

Abstract
Purpose: Non-alcoholic fatty liver disease (NAFLD) is the most preventable type of chronic liver disease worldwide and a risk factor for developing cirrhosis or hepatocellular carcinoma (HCC) if untreated. Although experts have performed lots of efforts to find the underlying mechanisms of NAFLD, it remains a challenge to recognize them. The aim of this study is to distinguish common gene signature and pathways in the human liver during NAFLD progression through the systems biology method.Methods: In this study, the three microarray datasets, GSE48452, GSE63067 and GSE89632, were selected from the NCBI GEO database to explore differentially expressed genes (DEGs) among healthy controls, simple steatosis and non-alcoholic steatohepatitis (NASH) patients. Furthermore, protein-protein interaction (PPI) networks and pathway enrichment analysis were used to detect common genes and biological pathways in different stages of NAFLD.Results: The current study was included 47 healthy subjects, 36 patients with simple steatosis and 46 NASH patients. Common high degree genes among all three sets were CHI3L1, GFBP2, NRG1, PEG10 and FADS2. The top five genes in the hepatic PPI networks of three datasets were STAT3, JUN, CANX, FN1 and MYC. Signal transduction, immune response, and anti-apoptosis were the most important biological pathways between healthy vs. NASH, while cell communication, signal transduction and immune response were three top biological pathways between healthy vs. simple steatosis. Also, the most eminent biological pathways between NASH vs. simple steatosis were metabolism and energy pathways. Conclusion: The present study represented the unique and shared key genes and pathways between different stages of NAFLD, which may facilitate the understanding of the NAFLD mechanism and identify potential therapeutic targets in this disease.
WITHDRAWN: Strength Analysis and Ratio Optimization of New Sealing Materials With Response Surface Method
Authors: Xue Sheng , Guo Xin , Li Yaobin , Zheng Chunshan 
Published: December 2020

Abstract
The influence of the interaction among water-cement ratio, content of expansion agent, water reducing agent, and retarder on the compressive strength of new sealing material was studied. The Design-Expert software was used to design experiments, establish a quadratic polynomial regression model, draw response surface, and optimize parameters. The microstructure morphology of the sample is explored by scanning electron microscope (Hereinafter referred to as SEM). The research results show that the interaction between water-cement ratio and expansion agent content is the most crucial factor affecting the compressive strength of the new sealing material. Under the optimal condition of 0.4% water reducing agent, 0.04% retarder, 0.8 water-cement ratio, and 8% expansion agent, the compressive strength of the sealing material cured for 3 d and 7 d is 39.247 MPa and 41.044 MPa, with the maximum absolute error of 1.71% and 2.81%, which proves the high accuracy of the model. The main hydration products of the new sealing material are ettringite and C-S-H gel, interlacing each other to form a dense structure, which contributes to the high strength of the new sealing material.
A Ten-year Experience of the Multidisciplinary Management of the Regional Failure of Nasopharyngeal Carcinoma in the Era of IMRT
Authors: Guan xiyin , Xing Xing , Wang Xiaoshen , He Xiayun , Ying Hongmei , Lu Xueguan , Shen Chunying , Zhang Qunling , Chen Jiaying , Sun Guohua , Wang Yu-Long , Wang Yu , Xu Tingting , Hu Chaosu 
Published: December 2020

Abstract
Objective: To evaluate clinical outcomes of cervical node recurrence/residual tumor of nasopharyngeal carcinoma (NPC) with treatment decisions made by a multidisciplinary treatment (MDT) team. Methods: Between March 2010 and July 2019, patients who had previously undergone definitive intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma and presented with residual or recurrent cervical lymph nodes were enrolled in our study. Clinical features and treatment modalities were retrospectively reviewed, and survival outcomes were analyzed. Results: A total of 183 patients were enrolled in the study, among whom 139 underwent neck dissection, and the remaining 44 were either considered not eligible for surgery or refused surgery. For the two groups of patients, the 3-year overall survival (OS) was 73.4% vs 36.8% (p=0.000), and the progression-free survival (PFS) was 57.1% vs 32.3% (p=0.004), respectively. Patients who underwent neck dissection had a significantly better clinical outcome and shorter latency between the prior treatment and detection of neck recurrence/residual tumor than those who did not. Conclusion: For regional failure cases that have no contradictions for surgery and are predicted to benefit from surgery by the MDT team, neck dissection could be the best choice. It is important for an experienced MDT team to choose the optimum treatment modalities for patients for the cervical failure of NPC. Regular follow-up after prior treatment contributes to the early detection of regional failure and provides a chance for surgery.
Pilot study in patients with congenital low-flow vascular malformation treated with low dose sirolimus
Authors: Harbers Veroniek , Rongen Gerard , Vleuten van der Carine , Verhoeven Bas , Laat de Peter , Horst van der Chantal , Klein Willemijn , Kool Leo Schultze , Loo te Maroeska 
Published: December 2020

Abstract
Background

Patients with congenital low-flow vascular malformations (capillary (CM), lymphatic (LM), venous (VM) or combined) may have an impaired quality of life (QoL), due to their symptoms, which include pain, swelling, bleeding, thrombosis, and functional impairment. Unfortunately, current treatment methods are challenging and not always successful. Previous studies have shown that the mTOR-inhibitor sirolimus is an effective treatment for these patients. Target levels of 10–15 ng/ml were well tolerated; however, grade three adverse events were observed (ranged 20–40%).
Methods

A pilot study was performed using a Challenge–Dechallenge–Rechallenge (CDR) design to determine the pharmacodynamics of low target levels of sirolimus (target levels 4–10 ng/ml) in respect of efficacy and adverse events in patients with disabling low-flow vascular malformations without treatment alternatives. The patients received sirolimus over a three-to-six-month period (Challenge), followed by the withdrawal of sirolimus (Dechallenge). If the complaints returned, sirolimus was reintroduced during a twelve month period (Rechallenge). Efficacy was determined on pain (end point of the pilot study) and other symptoms related to the vascular malformation; and adverse events were determined in all phases of the study.
Results

An improvement in symptoms was seen in 92% (n = 11/12) of patients during the Challenge phase. In the Rechallenge phase, a positive response rate of 78% was found (n = 7/9). These response rates are comparable to those found in the literature despite low target levels of sirolimus. However, less serious adverse events were observed with low dose sirolimus, especially bone marrow toxicity and grade III liver toxicity.
Conclusions

This pilot using low dose sirolimus showed high efficacy in patients with therapy resistant and disabling low-flow malformation, with a lower incidence of serious adverse events (especially bone marrow toxicity and grade III liver toxicity). This is extremely relevant to patients with low-flow vascular malformation, as current clinical protocols tend to advise lifelong treatment.
Trial registration

The pilot study was part of a phase III study. Trial registration: EudraCT number: 2016-002157-38 and ClinicalTrials.gov Identifier: NCT03987152, registered 06/14/2019 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03987152?term=sirolimus&cond=Vascular+Malformations&cntry=NL&draw=2&rank=1
Concurrent Targeting of MEG3 and Linc-ROR Increases the p53 Transcript in HCT116 Cells
Authors: Ramezani Mahbobeh , Shamsabadi Fatemeh , Shahbazi Majid 
Published: December 2020

Abstract
Recently, lncRNAs are used as a prospective strategy in cancer gene therapy. Dysregulation of the maternally expressed gene3 (MEG3) and the linc-ROR have demonstrated in colorectal cancer researches. This study evaluates the effect of concurrent silencing of linc-ROR and MEG3 activation on colon cancer cell survival in order to assess the p53 transcriptional activity and stability. The MEG3 and linc-ROR shRNA were cloned under the bidirectional CEA promoter (UM1). Transfection efficiency was examined by GFP expression under fluorescent microscope. Following transfection, the response of HCT116 cells was evaluated by MTS assay, apoptosis and cell cycle analyses. The expression of target genes along with the p53 were analyzed in the transcription level by qPCR.Proliferation of both cancer cell lines were significantly reduced at 48 h post-transfection. The UM1 significantly induced apoptosis in HCT116 (36.35%). Moreover, UM1 remarkably reduced the cell population in S phase. Also, concomitant up- and down-regulation of MEG3 and linc-ROR were attributed to the activation of p53 in transcription level. Concurrent silencing of linc-ROR and MEG3 activation in colon cancer cells resulted in the activation of p53 and reduced the cell proliferation. We found that the higher apoptosis induction was coupled with the enhancement of the p53 expression. The synergistic effect of target genes might serve as a useful approach for targeting p53 in colon cancer.
Selective Ablation of Cochlear Hair Cells Promotes Engraftment of Human Embryonic Stem Cells-derived Progenitors in The Mouse organ of Corti
Authors: Takeda Hiroki , Dondzillo Anna , Randall Jessica A. , Gubbels Samuel P. 
Published: December 2020

Abstract
Backgroud: Hearing loss affects 25% of the population at ages 60–69 years. Loss of the hair cells of the inner ear commonly underlies deafness and once lost this cell type cannot spontaneously regenerate in higher vertebrates. As a result there is a need for the development of regenerative strategies to replace hair cells once lost. Stem cell-based therapies are one such strategy and offer promise for cell replacement in a variety of tissues. A number of investigators have previously demonstrated successful implantation, and certain level of regeneration of hair and supporting cells in both avian and mammalian models using rodent pluripotent stem cells. However, the ability of human stem cells to engraft and generate differentiated cell types in the inner ear is not well understood. Methods: We differentiate human pluripotent stem cells to the pre-placodal stage in vitro then transplant them into the mouse cochlea after selective and complete lesioning of the endogenous population of hair cells. Results: We demonstrate that hair cell ablation prior to transplantation leads to increased engraftment in the auditory sensory epithelium, the organ of Corti, as well as differentiation of transplanted cells into hair and supporting cell immunophenotypes. Conclusion: We have demonstrated the feasibility of human stem cell engraftment into an ablated mouse organ of Corti.
Intravenous Administration of Umbilical Cord Mesenchymal Stromal Cells in Advanced-stage Critical COVID-19: a Case Report
Authors: Silva Katia Nunes , Pinheiro Priscila , Gobatto Andre , Passos Rogerio , Paredes Bruno , França Luciana , Nonaka Carolina , Barreto-Duarte Beatriz , Araújo-Pereira Mariana , Santos Rafael dos , Cruz Fernanda , Martins Gabriele , Andrade Bruno , Castro-Faria-Neto Hugo , Rocco Patricia , Souza Bruno Solano de Freitas 
Published: December 2020

Abstract
Background: Coronavirus disease 2019 (COVID-19) associated- severe acute respiratory distress syndrome (ARDS) patients may require prolonged mechanical ventilation, thus resulting in lung fibrosis and high fatality rates. Several therapies have been developed in patients with pneumonia requiring oxygen therapy as well as during the early course of invasive mechanical ventilation. Mesenchymal stromal cells (MSCs) may have a role in controlling the hyperinflammatory response seen in such cases and prevent aggravation or increase/accelerate recovery. While MSC-based therapies have been studied mostly in patients that did not require invasive ventilation or during the first hours of tracheal intubation, to date the potential of MSC therapy to treat advanced-stage of severe/critical COVID-19 cases has not been extensively studied. Methods: This is a case report of a 30-year-old male patient who presented progressive clinical deterioration of COVID-19 in ICU after 21-day admission and 14 days with invasive mechanical ventilation. The first symptom onset was 35 days before MSC therapy. The patient was treated with allogenic human umbilical cord-derived MSCs [5 x 107 (2 doses 2 days interval)].Results: No serious adverse events attributed to MSC administration were observed during and after the procedure. Oxygenation (PaO2/FiO2 ratio) and the need for vasoactive drugs improved. Chest CT scan imaging, which showed signs of bilateral and peripheral ground-glass, consolidation as well as fibrosis, improved significantly during the time course of the disease. Patient was discharged 13 days after cell therapy. Cytokine analysis demonstrated modulation of different mediators accompanied by modulation of different cell populations in peripheral blood, including a reduction in inflammatory monocytes, increased frequency of patrolling monocytes, CD4+ lymphocytes and type 2 classical dendritic cells (cDC2). Conclusion: This study described for the first time the effects of MSC therapy in a patient at late stage COVID-19 associated severe lung injury and fibrosis. Therefore, further clinical trials should be design assessing the efficacy of MSC therapy in ARDS patients undergoing prolonged mechanical ventilation due to COVID-19.