bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultural Hybridity in Conversion: An Examination of Hapkas Christology as Resistance and Innovation in Drusilla Modjeska’s The Mountain
Authors: Taylor Steve 
Published: October 2019

Abstract
This essay analyzes Christian witness, applying a post-colonial lens to Drusilla Modjeska’s The Mountain to account for conversion and transformation in Papua New Guinea. A hapkas (half-caste) Christology of indigenous agency, communal transformation and hybridity is examined in dialogue with New Testament themes of genealogy, redemption as gift and Jesus as the new Adam. Jesus as “good man true” is placed in critical dialogue with masculine identity tropes in Melanesian anthropology. Jesus as ancestor gift of Canaanite descent is located in relation to scholarship that respects indigenous cultures as Old Testament and post-colonial theologies of revelation which affirm cultural hybridity and indigenous innovation in conversion across cultures. This hapkas Christology demonstrates how a received message of Christian mission is transformed in a crossing of cultures.
Jonathan Chao and “Return Mission”: The Case of the Calvinist Revival in China
Authors: Chow Alexander 
Published: October 2019

Abstract
Studies on mission and migration have often focused on the propagation of Christianity from a home context to a foreign context. This is true of studies of Christian mission by Catholics and Protestants, but also true in the growing discussion of “reverse mission” whereby diasporic African and Korean missionaries evangelize the “heathen” lands of Europe and North America. This article proposes the alternative term “return mission” in which Christians from the diaspora return to evangelize the lands of their ancestral origins. It uses the case study of Jonathan Chao (Zhao Tian’en 趙天恩), a return missionary who traveled in and out of China from 1978 until near his death in 2004 and is considered an instrumental figure in the revival of Calvinism in China. This article suggests that “return mission” provides a new means to understand the subjects of mission and migration, and raises new challenges to questions about paternalism and independency.
Atmospheric Predictability of the Tropics, Middle Latitudes, and Polar Regions Explored through Global Storm-Resolving Simulations
Authors: Judt Falko 
Published: October 2019

AbstractThe predictability of the atmosphere has important implications for weather prediction, because it determines what forecast problems are potentially tractable. Even though our general understanding of error growth and predictability has been increasing, relatively little is known about the detailed structure of atmospheric predictability, such as how it varies between climate regions. The present study addresses this issue by exploring error growth and predictability in three latitude zones, using model output from a previous global storm-resolving predictability experiment by Judt published in 2018. It was determined that the tropics have longer predictability than the middle latitudes and polar regions (tropics, >20 days; middle latitudes and polar regions, a little over 2 weeks). Each latitude zone had distinct error growth characteristics, and error growth was broadly consistent with the underlying dynamics of each zone. Evidence suggests that equatorial waves play a role in the comparatively long predictability of the tropics; specifically, equatorial waves seem to be less prone to error growth than middle-latitude baroclinic disturbances. Even though the generality of the findings needs to be assessed in future studies, the overall conclusions agree with previous work in that current numerical weather prediction procedures have not reached the limits of atmospheric predictability, especially in the tropics. One way to exploit tropical predictability is to reduce model error, for example, by using global storm-resolving models instead of conventional models that parameterize convection.
Reconstructing Upper-Ocean Vertical Velocity Field from Sea Surface Height in the Presence of Unbalanced Motion
Authors: Qiu Bo , Chen Shuiming , Klein Patrice , Torres Hector , Wang Jinbo , Fu Lee-Lueng , Menemenlis Dimitris 
Published: October 2019

AbstractReconstructability of upper-ocean vertical velocity w and vorticity ζ fields from high-resolution sea surface height (SSH) data is explored using the global 1/48° horizontal-resolution MITgcm output in the context of the forthcoming Surface Water and Ocean Topography (SWOT) mission. By decomposing w with an omega equation of the primitive equation system and by taking into account the measurement design of the SWOT mission, this study seeks to reconstruct the subinertial, balanced w and ζ signals. By adopting the effective surface quasigeostrophic (eSQG) framework and applying to the Kuroshio Extension region of the North Pacific, we find that the target and reconstructed fields have a spatial correlation of ~0.7 below the mixed layer for w and 0.7–0.9 throughout the 1000-m upper ocean for ζ in the error-free scenario. By taking the SWOT sampling and measurement errors into account, the spatial correlation is found to decrease to 0.4–0.6 below the mixed layer for w and 0.6–0.7 for ζ, respectively. For both w and ζ reconstruction, the degradation due to the SWOT errors is more significant in the surface layer and for smaller-scale signals. The impact of errors lessens with the increasing depth and lengthening horizontal scales.
Neuroanatomical Abnormalities in Older Depressed Adults With Apathy: A Systematic Review
Authors: Pimontel Monique A. , Kanellopoulos Dora , Gunning Faith M. 
Published: October 2019

Objective: Apathy is a common phenomenon in late-life depression and is associated with poor outcomes. Apathy is often unrecognized in older depressed adults, and efficacious treatment options are lacking. This review provides a systematic review of the neuroanatomical abnormalities associated with apathy in late-life depression. In addition, the review summarizes the neuroimaging findings from studies of neurodegenerative and focal brain injury conditions that frequently present with apathy. The goal is to elucidate cerebral network abnormalities that give rise to apathy in older adults with mood disturbances and to inform future treatment targets. Method: Systematic literature review. Results: The few studies that have directly examined the neuroanatomical abnormalities of apathy in late-life depression suggest disturbances in the anterior cingulate cortex, insula, orbital and dorsal prefrontal cortex, striatum, and limbic structures (ie, amygdala, thalamus, and hippocampus). Studies examining the neuroanatomical correlates of apathy in other aging populations are consistent with the pattern observed in late-life depression. Conclusions: Apathy in late-life depression appears to be accompanied by neuroanatomical abnormalities in the salience and reward networks. These network findings are consistent with that observed in individuals presenting with apathy in other aging-related conditions. These findings may inform future treatments that target apathy.
Hindi LupusPRO: cross cultural validation of disease specific patient reported outcome measure of lupus
Authors: Pinto B , Jolly M , Dhooria A , Grover S , Raj J M , Devilliers H , Sharma A 
Published: October 2019

Background LupusPRO is a SLE specific patient reported outcomes measure developed and validated in the USA. This study aimed to validate the Hindi version of LupusPRO in systemic lupus erythematosus (SLE) patients in India. Methods Disease activity and damage were assessed using SELENA–SLEDAI and SLICC/ACR damage Index respectively. Demographic and clinical features were recorded. The Hindi Version of LupusPRO and 36-Item Short Form Health Survey (SF-36) were administered for assessment of quality of life. Depression, anxiety and fatigue were assessed using Patient Health Questionnaire 9 (PHQ9), Generalized Anxiety Disorder 7 (GAD7) and Fatigue Severity Scale (FSS) respectively. Internal consistency reliability, test-retest reliability, convergent and discriminant validity (against corresponding domains of the SF-36, fatigue, depression and anxiety), criterion validity (against disease activity and damage) and known group validity were tested. Results A total of 144 (140 females) patients with SLE with a mean age of 32.48 ± 7.26 years participated in the study. The median (interquartile range) SELENA SLEDAI was 2 (5.5). The internal consistency reliability of the LupusPRO domains was >0.7 for most domains (except for lupus symptoms, lupus medication, procreation and social support).We noted good convergent validity of LupusPRO domains with corresponding domains of SF-36, pain vitality with fatigue (FSS) and emotional health domain with depression (PHQ9) and anxiety (GAD7). Criterion validity of lupus symptoms with disease activity was observed. Known group validity of the LupusPRO domains with patient reported health status was observed. Confirmatory factor analysis showed a good fit. Conclusion The Hindi LupusPRO has fair psychometric properties among Indian patients with SLE.
Total corneal refractive power and shape in Down syndrome
Authors: Asgari Soheila , Mehravaran Shiva , Fotouhi Akbar , Makateb Ali , Hashemi Hassan 
Published: October 2019

Purpose: To determine the total corneal refractive power in 1–8 mm corneal zones and the 8 mm Q-value in non-keratoconic patients with Down syndrome and normal subjects aged 10–30 years. Methods: Right eye data from 203 Down syndrome patients (mean ± standard deviation age: 17.0 ± 4.7 years) and 189 age- and gender-matched normal subjects (17.1 ± 4.5 years) were compared. Main extracted Pentacam indices were total corneal refractive power in steep and flat axes, and mean and difference (corneal astigmatism) total corneal refractive power in 1–8 mm zones. Results: Mean total corneal refractive power in 1–8 mm zones was 45.17–45.74 D and 42.91–43.52 D in Down and normal group, respectively (all p < 0.001). The coefficients of variation of total corneal refractive power from the center to the periphery were similar in the two groups (p = 0.855). None of the mean total corneal refractive powers significantly correlated with age, and all of them were significantly higher in females (p < 0.001). Mean total corneal refractive power–based corneal astigmatism in these zones changed from 1.46 to 1.66 D in Down syndrome patients and 1.64 to 1.99 D in normal group. All corneal astigmatism indices were similar between two groups (all p > 0.05). The prevalence of against the rule and oblique astigmatism in all zones were higher in the Down syndrome group (all p < 0.05). Conclusion: Adolescent and young non-keratoconic patients with Down syndrome have a more prolate cornea and a homogeneous keratometry distribution. In this population, females have a steeper cornea.
Computerized neuropsychological assessment devices in multiple sclerosis: A systematic review
Authors: Wojcik Curtis M , Beier Meghan , Costello Kathleen , DeLuca John , Feinstein Anthony , Goverover Yael , Gudesblatt Mark , Jaworski Michael , Kalb Rosalind , Kostich Lori , LaRocca Nicholas G , Rodgers Jonathan D , Benedict Ralph HB ,   National MS Society Cognition Work Team
Published: October 2019

Background: The proliferation of computerized neuropsychological assessment devices (CNADs) for screening and monitoring cognitive impairment is increasing exponentially. Previous reviews of computerized tests for multiple sclerosis (MS) were primarily qualitative and did not rigorously compare CNADs on psychometric properties. Objective: We aimed to systematically review the literature on the use of CNADs in MS and identify test batteries and single tests with good evidence for reliability and validity. Method: A search of four major online databases was conducted for publications related to computerized testing and MS. Test–retest reliability and validity coefficients and effect sizes were recorded for each CNAD test, along with administration characteristics. Results: We identified 11 batteries and 33 individual tests from 120 peer-reviewed articles meeting the inclusion criteria. CNADs with the strongest psychometric support include the CogState Brief Battery, Cognitive Drug Research Battery, NeuroTrax, CNS-Vital Signs, and computer-based administrations of the Symbol Digit Modalities Test. Conclusion: We identified several CNADs that are valid to screen for MS-related cognitive impairment, or to supplement full, conventional neuropsychological assessment. The necessity of testing with a technician, and in a controlled clinic/laboratory environment, remains uncertain.
Amino Acids Responsible for Decreased 2, 3-Biphosphosphoglycerate Binding to Fetal Hemoglobin
Authors: Adachi Kazuhiko , Konitzer Patrick , Pang Jian , Reddy Konda S. , Surrey Saul 
Published: October 2019

AbstractTo clarify the role of γN-terminal Gly, γ5 Glu, and γ143 Ser in 2, 3-biphosphosphoglycerate (BPG) binding to fetal hemoglobin (Hb F ), we engineered and produced normal human Hb F and two Hb F variants (Hb F γG1V, γS143H, and Hb F γG1V, γE5P, γS143H) using a yeast expression system and then compared their oxygen-binding properties with those of native human Hb F and adult Hb (Hb A). Oxygen affinity of Hb F γG1V, γS143H in the absence of 2, 3-BPG was slightly higher than that of normal Hb F. The decrease in oxygen affinities for Hb F γG1V, γS143H with increasing 2, 3-BPG concentrations was larger than that of normal Hb F, but significantly less than that of Hb A. In contrast, oxygen affinities of Hb F γG1V, γE5P, γS143H in the absence and presence of 2, 3-BPG were much lower than those of Hb F γG1V, γS143H and were similar to those of Hb A. These results indicate that differences between Pro and Glu at the A2 position in the A helix in Hb A and Hb F, respectively, are critical for reduced binding of 2, 3-BPG to Hb F, even though β5 Pro does not interact directly with 2, 3-BPG in Hb A. Hb F variants such as Hb F γG1V, γE5P, γS143H, which exhibit reduced oxygen affinity, should facilitate design of efficient antisickling fetal Hb variants for potential use in gene therapy for sickle cell disease.
Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern
Authors: Berger Gerbrig , Gerritsen Mylene , Yi Guoqiang , Koorenhof-Scheele Theresia N. , Kroeze Leonie I. , Stevens-Kroef Marian , Yoshida Kenichi , Shiraishi Yuichi , van den Berg Eva , Schepers Hein , Huls Geert , Mulder André B. , Ogawa Seishi , Martens Joost H. A. , Jansen Joop H. , Vellenga Edo 
Published: October 2019

Key PointsRing sideroblasts in AML are associated with complex karyotypes and TP53 mutations. Gene expression studies in CD34+ AML cells suggest an altered erythroid differentiation program in AML with ring sideroblasts.
The expression of P16 and S100 associated with elastin degradation and fibrosis of the Ligamentum Flavum hypertrophy
Authors: Hu Wei , Kan Shunli , Liu Guang , Cao Zegang , Zhu Rusen 
Published: October 2019

Abstract

Background
One of the characteristics of lumbar spinal stenosis (LSS) is elastin degradation and fibrosis in the ligamentum flavum (LF). However, the biochemical factors that cause these histologic changes is unclear. P16 and S100 participate in scar formation and collagen development in wound healing and fibrosis diseases. In this study, we investigate the association between P16 and S100 expression and the fibrosis of the hypertrophic LF in LSS.

Methods
The LF specimens were surgically obtained from 30 patients with single-segment LSS (SLSS), 30 patients with double-segment LSS (DLSS) and 30 patients with L4/5 lumbar disc herniation (LDH). The LF thickness was measured by axial T1-weighted MRI. The extent of LF elastin degradation and fibrosis were graded based on hematoxylin-eosin (HE) and Verhoff’s Van Gieson’s (VVG) stain, respectively. The localization of P16 and S100 was determined by immunohistochemistry.

Results
The Absolute and relative LF thickness were greater in the DLSS group compared with the SLSS and LDH groups (p <  0.05). The elastic tissue from the dorsal aspect to the dural aspect in SLSS and DLSS groups was significantly increased. The amount of collagen deposition and elastic tissue is significantly higher in the DLSS group compared with the SLSS and LDH groups (p <  0.05). The specimens in the DLSS group showed positive staining of P16, especially in the dorsal layer. Almost all samples in the SLSS group were partially positive for P16. The LDH group showed negative staining of P16 in both the dural and dorsal layers. All the three groups were stained with S100 in the dorsal layer of the LF. On the contrary, S100 staining was absent in the dural layer of the LF in the three groups.

Conclusions
Elastin degradation and fibrosis of the LF in the DLSS patients is more severe compared with the SLSS and LDH patients. Increased expression of P16 associated with LF fibrosis and thickness, suggested that the expression of P16 may related to LF hypertrophy in the patients who suffer with LSS. LF hypertrophy process may not be associated with high expression of S100.
The StarT back screening tool and a pain mannequin improve triage in individuals with low back pain at risk of a worse prognosis – a population based cohort study
Authors: Haglund Emma , Bremander Ann , Bergman Stefan 
Published: October 2019

AbstractBackgroundThe STarT Back Screening Tool (SBT) identifies patients with low back pain (LBP) at risk of a worse prognosis of persistent disabling back pain, and thereby facilitates triage to appropriate treatment level. However, the SBT does not consider the pain distribution, which is a known predictor of chronic widespread pain (CWP). The aim of this study was to determine if screening by the SBT and screening of multisite chronic widespread pain (MS-CWP) could identity individuals with a worse prognosis. A secondary aim was to analyze self-reported health in individuals with and without LBP, in relation to the combination of these two screening tools.MethodsOne hundred and nineteen individuals (aged 40–71 years, mean (SD) 59 (8) years), 52 with LBP and 67 references, answered two screening tools; the SBT and a pain mannequin – as well as a questionnaire addressing self-reported health. The SBT stratifies into low, medium or high risk of a worse prognosis. The pain mannequin stratifies into either presence or absence of CWP in combination with ≥7 painful areas of pain (0–18), here defined as MS-CWP (high risk of worse prognosis). The two screening tools were studied one-by-one, and as a combined screening. For statistical analyses, independent t-tests and Chi-square tests were used.ResultsBoth the SBT and the pain mannequin identified risk of a worse prognosis in individuals with (p = 0.007) or without (p = 0.001) LBP. We found that the screening tools identified partly different individuals at risk. The SBT identified one individual, while the pain mannequin identified 21 (19%). When combining the two screening methods, 21 individuals (17%) were at high risk of a worse prognosis. When analyzing differences between individuals at high risk (combined SBT and MS-CWP) with those at low risk, individuals at high risk reported worse health (p = 0.013 - < 0.001).ConclusionsBoth screening tools identified individuals at risk, but they captured different aspects, and also different number of individuals at high risk of a worse prognosis. Thus, using a combination may improve early detection and facilitate triage to appropriate treatment level with multimodal approach also in those otherwise missed by the SBT.
Size matters: how sample size affects the reproducibility and specificity of gene set analysis
Authors: Maleki Farhad , Ovens Katie , McQuillan Ian , Kusalik Anthony J. 
Published: October 2019

AbstractBackgroundGene set analysis is a well-established approach for interpretation of data from high-throughput gene expression studies. Achieving reproducible results is an essential requirement in such studies. One factor of a gene expression experiment that can affect reproducibility is the choice of sample size. However, choosing an appropriate sample size can be difficult, especially because the choice may be method-dependent. Further, sample size choice can have unexpected effects on specificity.ResultsIn this paper, we report on a systematic, quantitative approach to study the effect of sample size on the reproducibility of the results from 13 gene set analysis methods. We also investigate the impact of sample size on the specificity of these methods. Rather than relying on synthetic data, the proposed approach uses real expression datasets to offer an accurate and reliable evaluation.ConclusionOur findings show that, as a general pattern, the results of gene set analysis become more reproducible as sample size increases. However, the extent of reproducibility and the rate at which it increases vary from method to method. In addition, even in the absence of differential expression, some gene set analysis methods report a large number of false positives, and increasing sample size does not lead to reducing these false positives. The results of this research can be used when selecting a gene set analysis method from those available.
Using Apache Spark on genome assembly for scalable overlap-graph reduction
Authors: Paul Alexander J. , Lawrence Dylan , Song Myoungkyu , Lim Seung-Hwan , Pan Chongle , Ahn Tae-Hyuk 
Published: October 2019

AbstractBackgroundDe novo genome assembly is a technique that builds the genome of a specimen using overlaps of genomic fragments without additional work with reference sequence. Sequence fragments (called reads) are assembled as contigs and scaffolds by the overlaps. The quality of the de novo assembly depends on the length and continuity of the assembly. To enable faster and more accurate assembly of species, existing sequencing techniques have been proposed, for example, high-throughput next-generation sequencing and long-reads-producing third-generation sequencing. However, these techniques require a large amounts of computer memory when very huge-size overlap graphs are resolved. Also, it is challenging for parallel computation.ResultsTo address the limitations, we propose an innovative algorithmic approach, calledScalableOverlap-graphReductionAlgorithms (SORA). SORA is an algorithm package that performs string graph reduction algorithms by Apache Spark. The SORA’s implementations are designed to execute de novo genome assembly on either a single machine or a distributed computing platform. SORA efficiently compacts the number of edges on enormous graphing paths by adapting scalable features of graph processing libraries provided by Apache Spark, GraphX and GraphFrames.ConclusionsWe shared the algorithms and the experimental results at our project website,https://github.com/BioHPC/SORA. We evaluated SORA with the human genome samples. First, it processed a nearly one billion edge graph on a distributed cloud cluster. Second, it processed mid-to-small size graphs on a single workstation within a short time frame. Overall, SORA achieved the linear-scaling simulations for the increased computing instances.
Study on ultra-high sensitivity piezoelectric effect of GaN micro/nano columns
Authors: Fu Jianbo , Zong Hua , Hu Xiaodong , Zhang Haixia 
Published: October 2019

Abstract
High-quality GaN micro/nano columns were prepared with self-organized catalytic-free method. Young’s modulus of GaN nanocolumns were measured under both compressive stress and tensile stress. It was found that the Young’s modulus decreases with the increasing of nanocolumn diameter due to the increase of face defect density. Furthermore, we measured the piezoelectric properties and found that there was a 1000-fold current increase under a strain of 1% with a fixed bias voltage of 10 mV. Based on the Schottky Barrier Diode model, we modified it with the effect of polarization charge, image charge and interface state to analyze the experiment results which reveals that the strong piezopolarization effect plays an important role in this phenomenon. Therefore, the GaN nanocolumns has a great prospect to be applied in high-efficiency nanogenerators and high-sensitivity nanosensors.