bluuebunny/crossref_metadata_2025_split huggingface dataset:
The tensor t‐function: A definition for functions of third‐order tensors
Authors: Lund Kathryn 
Published: February 2020

SummaryA definition for functions of multidimensional arrays is presented. The definition is valid for third‐order tensors in the tensor t‐product formalism, which regards third‐order tensors as block circulant matrices. The tensor function definition is shown to have similar properties as standard matrix function definitions in fundamental scenarios. To demonstrate the definition's potential in applications, the notion of network communicability is generalized to third‐order tensors and computed for a small‐scale example via block Krylov subspace methods for matrix functions. A complexity analysis for these methods in the context of tensors is also provided.
Multimodal treatment including standard chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide for the Ewing sarcoma family of tumors in Japan: Results of the Japan Ewing Sarcoma Study 04
Authors: Chin Motoaki , Yokoyama Ryohei , Sumi Minako , Okita Hajime , Kawai Akira , Hosono Ako , Koga Yuhki , Sano Hideki , Watanabe Hiroyoshi , Ozaki Toshifumi , Mugishima Hideo ,   Japan Ewing Sarcoma Study Group (JESS)
Published: February 2020

AbstractBackgroundThe survival rate in patients with Ewing sarcoma family of tumors (ESFT) in Japan was reported to be < 50% in the 1990s. The Japan Ewing Sarcoma Study Group was established to improve the prognosis of ESFT in Japan. The aim of this phase II trial was to determine the efficacy and safety of multimodal treatment for nonmetastatic ESFT.ProcedurePatients with ESFT aged < 30 years were eligible for participation. The chemotherapy regimen consisted of vincristine, doxorubicin, and cyclophosphamide (VDC) alternating with ifosfamide and etoposide (IE) repeating every 21 days for 52 weeks. Local treatment included surgery and/or radiation therapy (0‐55.8 Gy) based on the margin of resection and histologic response. The primary endpoint was progression‐free survival (PFS) at three years. The study was designed to test whether the lower limit of the 90% confidence interval for PFS would exceed the threshold of 60%. The planned sample size was 53 patients, allowing for 10% of patients being ineligible.ResultsOf the 53 patients screened for entry, seven were deemed ineligible. Forty‐six patients were considered as the per‐protocol set and were used for the efficacy analysis. Three‐year PFS was 71.7% (0.59‐0.81). Estimated five‐year PFS and overall survival were both 69.6%. Although no previously unknown adverse event was reported, three patients developed secondary malignancies (acute lymphoblastic leukemia, myelodysplastic syndrome, and osteosarcoma, one patient each).ConclusionsMultimodal treatment with standard VDC‐IE chemotherapy improved the prognosis for patients with ESFT in Japan, although statistical confirmation of efficacy compared to historical control was not achieved.
Registration of ‘DALZ 1308’ zoysiagrass
Authors: Chandra Ambika , Genovesi Anthony D. , Meeks Meghyn , Wu Ying , Engelke Milt C. , Kenworthy Kevin , Schwartz Brian 
Published: February 2020

Abstract‘DALZ 1308’ (Reg. no. CV‐285, PI 691612) is a first‐generation interspecific hybrid developed in 2004 by crossing a genotype of Zoysia minima (Colenso) Zotov and Z. matrella (L.) Merr. ‘Diamond.’ After field evaluations in Dallas, TX (2004–2009) and Gainesville, FL (2006–2008), DALZ 1308 was selected for advancement to the 2013 Warm‐season Putting Greens National Turfgrass Evaluation Program (NTEP). DALZ 1308 was evaluated at 10 NTEP locations (2013–2018) as well as in Dallas, TX (2014–2017) and Gainesville, FL (2013–2017). DALZ 1308 exhibited a diminutive growth habit with narrower and shorter leaf blades and dwarf canopy height as compared to Diamond and L1F; shorter internode length, smaller node, and smaller internode diameter as compared to L1F; superior ball roll as compared to Diamond and L1F in Arizona, Kentucky, and Texas; resistance to tawny mole crickets; and reduced seedhead incidence and density during the growing season. As compared to Diamond and L1F, DALZ 1308 has shown to have reduced winter injury with fabric cover in Bloomington, IN. Although characteristics varied by location, DALZ 1308 exhibits good turfgrass quality, high shoot density, medium‐green genetic color, and extended fall and winter color retention. Initial greenhouse experimentation under moderate shade shows that DALZ 1308 has a greater percent green cover as compared to ‘Palisades’, Diamond, and ‘Zorro’. Overall, DALZ 1308 is an ultradwarf zoysiagrass suitable for golf course putting greens in a wide range of environments across the United States.
The tangled historical roots of entrepreneurial growth aspirations
Authors: Decker Stephanie , Estrin Saul , Mickiewicz Tomasz 
Published: February 2020

AbstractResearch SummaryWe consider what configurations of historical and geographic dimensions influence entrepreneurial growth aspirations (EGA). Our theoretical framework combines geography (coastal location, resource dependence), long‐term colonial history (ethnic heterogeneity, legal origins), and postcolonial history (low levels of conflict and population displacement; not having “bad neighbors”). We employ abductive reasoning to link the social science and historical literatures via analytically structured histories of Ghana, Nigeria, and Angola. Next, we undertake a fuzzy set qualitative comparative analysis on sub‐Saharan Africa countries to investigate which particular configurations of these dimensions are important for EGA. We demonstrate the importance of configurations over individual variables and add context‐bound dimensions to the study of entrepreneurship in developing countries, through historical analysis.Managerial SummaryOur analysis may offer entrepreneurs a template for identifying potential opportunities and threats in order to calibrate their strategies for scaling up their venture in sub‐Saharan Africa. We argue that environments rich in entrepreneurial growth opportunities are associated with configurations where negative aspects are more than compensated by positive ones. For Botswana, the low levels of internal conflict compensate for unfavorable location. For Angola, the positive impact of coastal location and relatively low ethnic heterogeneity counterbalance the negative effect of resource rents. Resource‐driven economies are more entrepreneurial: better economic opportunities can sometimes result from having extractive industries. For African entrepreneurs it is not only relevant what happens in their own countries, as their opportunities are directly affected by economic or political turmoil in neighboring countries.
Local strong solutions to a quasilinear degenerate fourth-order thin-film equation
Authors: Lienstromberg Christina , Müller Stefan 
Published: February 2020

AbstractWe study the problem of existence and uniqueness of strong solutions to a degenerate quasilinear parabolic non-Newtonian thin-film equation. Originating from a non-Newtonian Navier–Stokes system, the equation is derived by lubrication theory and under the assumption that capillarity is the only driving force. The fluid’s shear-thinning rheology is described by the so-called Ellis constitutive law. For flow behaviour exponents $$\alpha \ge 2$$α≥2 the corresponding initial boundary value problem fits into the abstract setting of Amann (Function Spaces, Differential Operators and Nonlinear Analysis, Vieweg Teubner Verlag, Stuttgart, 1993). Due to a lack of regularity this is not true for flow behaviour exponents $$\alpha \in (1,2)$$α∈(1,2). For this reason we prove an existence theorem for abstract quasilinear parabolic evolution problems with Hölder continuous dependence. This result provides existence of strong solutions to the non-Newtonian thin-film problem in the setting of fractional Sobolev spaces and (little) Hölder spaces. Uniqueness of strong solutions is derived by energy methods and by using the particular structure of the equation.
Condylar alterations and facial growth in children with juvenile idiopathic arthritis
Authors: Cedströmer Anna-Lena , Andlin-Sobocki Anna , Abbu Nadjwan , Hedenberg-Magnusson Britt , Dahlström Lars , Berntson Lillemor 
Published: February 2020

AbstractPurposeThe aim of this retrospective study was to evaluate facial growth in children with juvenile idiopathic arthritis (JIA) by means of lateral head cephalometric radiographs and relate the findings to temporomandibular joint (TMJ) condylar changes on panoramic radiographs.MethodsRadiographic and medical records were evaluated in 65 children with JIA. Cephalometric and panoramic analyses were performed for the impact of condylar changes on facial growth. We compared children with condylar alterations, minor or major, with those without condylar alterations.ResultsBased on panoramic radiographs, no condylar alterations were seen in 27 of the 65 children and condylar alterations were seen in 38 children (i.e., 23 had minor and 15 major condylar alterations). The cephalometric analyses of the children with condylar changes showed significant growth disturbances with a more retrognathic mandible (SNB;p = 0.03), retruded chin position (SNPog;p = 0.02), larger mandibular angulation (ML/NSL;p = 0.009) and maxillary angulation (NL/NSL;p = 0.03) compared with children without condylar alterations. Children with minor condylar alterations had a significantly more retruded chin position (SNPog) than those with no condylar changes (p = 0.04).ConclusionsCondylar changes in the TMJ, judged on panoramic radiography, in children with JIA, have impact on craniofacial growth. Even minor alterations seem to have an impact.
Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia
Authors: Schieck Maximilian , Lentes Jana , Thomay Kathrin , Hofmann Winfried , Behrens Yvonne Lisa , Hagedorn Maike , Ebersold Juliane , Davenport Colin F. , Fazio Grazia , Möricke Anja , Buchmann Swantje , Alten Julia , Cario Gunnar , Schrappe Martin , Bergmann Anke Katharina , Stanulla Martin , Steinemann Doris , Schlegelberger Brigitte , Cazzaniga Giovanni , Göhring Gudrun 
Published: February 2020

AbstractRisk-adapted therapy has significantly contributed to improved survival rates in pediatric acute lymphoblastic leukemia (ALL) and reliable detection of chromosomal aberrations is mandatory for risk group stratification. This study evaluated the applicability of panel-based RNA sequencing and array CGH within the diagnostic workflow of the German study group of the international AIEOP-BFM ALL 2017 trial. In a consecutive cohort of 117 children with B cell precursor (BCP) ALL, array analysis identified twelve cases with an IKZF1plus profile of gene deletions and one case of masked hypodiploidy. Genetic markers BCR-ABL1 (n = 1), ETV6-RUNX1 (n = 25), and rearrangements involving KMT2A (n = 3) or TCF3 (n = 3) were assessed by established conventional techniques such as karyotyping, FISH, and RT-PCR. Comparison of these results with RNA sequencing analysis revealed overall consistency in n=115/117 cases, albeit with one undetected AFF1-KMT2A fusion in RNA sequencing and one undetected ETV6-RUNX1 fusion in conventional analyses. The combined application of RNA sequencing, FISH, and CGH+SNP array reliably detected all genetic markers necessary for risk stratification and will be used as the diagnostic standard workflow for BCP-ALL patients enrolled in the AIEOP-BFM ALL 2017 study. Prospectively, consistent collection of genome-wide CGH+SNP array as well as RNA sequencing data will be a valuable source to elucidate new prognostic lesions beyond established markers of pediatric ALL. In this respect, RNA sequencing identified various gene fusions in up to half of the IKZF1plus (n = 6/12) and B-other (n = 19/36) cases but not in cases with hyperdiploid karyotypes (n = 35). Among these fusions, this study reports several previously undescribed in frame PAX5 fusions, including PAX5-MYO1G and PAX5-NCOA6.
Significant decrease of von Willebrand factor and plasminogen activator inhibitor-1 by providing supplementation with selenium and coenzyme Q10 to an elderly population with a low selenium status
Authors: Alehagen Urban , Alexander J. , Aaseth J. , Larsson A. , Lindahl T. L. 
Published: February 2020

Abstract
Purpose
Endothelial dysfunction and inflammation are conditions which fuel atherosclerosis and ischaemic heart disease. We have previously reported reduced cardiovascular (CV) mortality following supplementation with selenium and coenzyme Q10 to 443 elderly individuals with low selenium status (mean 67 μg/L) for 4 years. Here, we wanted to evaluate a possible association between the supplementation and the plasma concentrations of the von Willebrand factor (vWf), and the plasminogen activator inhibitor-1 (PAI-1), as they, besides other functions, are also strongly associated with endothelial function.

Methods
In this sub-study, 308 individuals (active substance: 157, placebo: 151) were included. Blood samples were drawn after 6 and 36 months and vWf and PAI-1 were determined in plasma by ELISA. Changes in concentrations of the biomarkers were evaluated by the use of T tests, repeated measures of variance, and ANCOVA analyses.

Results
The active treatment group presented a lower level of vWf after 36 months compared with the placebo group (1.08 U/mL vs. 5.10 U/mL; p = 0.0007). The results were validated through the repeated measures of variance evaluation. The PAI-1 levels showed an equally significant decrease in the active group (26.2 ng/mL vs. 49.2 ng/mL; p = 0.0002) and were also validated through repeated measures of variance evaluation.

Conclusion
In this sub-study on elderly receiving selenium and coenzyme Q10, or placebo we found significantly lower levels of vWf and PAI-1 in the active treatment group as compared to the placebo group. We interpret this as a better endothelial function because of the intervention, which accords with a previous finding of reduced CV mortality.
Sensory perception testing by monofilaments in the digits of controls and workers with HAVS
Authors: Poole C. J. M. , Robinson E. W. , Frost G. 
Published: February 2020

Abstract
Objective
To determine if heavy manual work affects sensory perception in the digits and whether Semmes–Weinstein monofilaments (SWM) can be used as a screening tool to detect sensory neuropathy in the digits of workers exposed to hand-transmitted vibration (HTV).

Methods
A cross-sectional study of office workers, heavy manual workers not exposed to HTV and workers with hand-arm vibration syndrome (HAVS). Sensory perception was measured in the digits by SWM using a forced-choice method to determine variability by sex, age, hand and digit. Frequency distributions were used to determine limit values and linear weighted kappa for intra-digit variability. Poisson regression was used to explore the relationship between sensory perception by SWM and abnormalities of thermal and vibration perception in the hands of workers with HAVS.

Results
The sensory perception threshold of office workers did not vary by hand or digit. It was significantly lower in women < 30 than women aged ≥ 30 years. The 95th percentile for heavy manual workers was 1.00 (95% CI 0.60–1.00) and significantly higher than for office workers at 0.16 (95% CI 0.16–0.16). Heavy manual workers > 50 years had the highest threshold at 1.40 (95% CI 1.00–2.00). Weighted kappa for reliability was 0.63 (95% CI 0.53–0.70). A mean SWM threshold of ≥ 1.0 gram-force had a 79% sensitivity and 64% specificity for detecting abnormalities of thermal and vibration perception in the ipsilateral index and little fingers of workers with HAVS.

Conclusions
SWM are a useful screening tool for detecting sensory loss in the digits of workers exposed to HTV.
Cost-effectiveness analysis of voice rehabilitation for patients with laryngeal cancer: a randomized controlled study
Authors: Johansson Mia , Finizia Caterina , Persson Josefine , Tuomi Lisa 
Published: February 2020

Abstract
Introduction
Voice problems are common following radiotherapy for laryngeal cancer. Few studies exist covering the effect of voice rehabilitation, and no previous studies exist regarding the cost of said rehabilitation. This randomized controlled study aimed to analyze the cost-effectiveness of voice rehabilitation after radiotherapy for patients with laryngeal cancer.

Material and methods
A total of 66 patients with laryngeal cancer with follow-up data 12 months post-radiotherapy were included. Patients were randomized into receiving either voice rehabilitation (n = 32) or no voice rehabilitation (n = 34). The patient outcome was measured as quality-adjusted life years (QALYs). The index range between 0 and 1, where 0 equals death and 1 represents perfect health. The QALYs were assessed with the European Organization for Research and Treatment of Cancer questionnaire QLQ-C30 mapped to EuroQoL 5 Dimension values. The cost of rehabilitation and other healthcare visits was derived from hospital systems. The patients reported the total amount of sick leave days during the first 12 months following radiotherapy. The cost-effectiveness of the voice rehabilitation was compared with no rehabilitation intervention based on the incremental cost-effectiveness ratio.

Results
The cost per gained QALY with voice rehabilitation compared to no rehabilitation from a societal perspective was − 27,594 € (SEK − 250,852) which indicates that the voice rehabilitation is a cost-saving alternative compared to no rehabilitation due to lower costs and a slightly better health outcome. From a healthcare perspective, the voice rehabilitation indicates a cost 60,800 € (SEK 552,725) per gained QALY.

Conclusion
From a societal perspective, i.e., including the costs of production loss, voice rehabilitation compared to no voice rehabilitation following radiotherapy for laryngeal cancer seems to be cost-saving. When analyzing only the healthcare costs in relation to health outcomes, voice rehabilitation indicates an incremental cost of 60,800 € per gained QALY, which is just above the threshold of the maximum willingness to pay level.
Long-term outcomes after contaminated complex abdominal wall reconstruction
Authors: de Vries F. E. E. , Hodgkinson J. D. , Claessen J. J. M. , van Ruler O. , Leo C. A. , Maeda Y. , Lapid O. , Obdeijn M. C. , Tanis P. J. , Bemelman W. A. , Constantinides J. , Hanna G. B. , Warusavitarne J. , Vaizey C. , Boermeester M. A. 
Published: February 2020

Abstract
Purpose
Complex abdominal wall repair (CAWR) in a contaminated operative field is a challenge. Available literature regarding long-term outcomes of CAWR comprises studies that often have small numbers and heterogeneous patient populations. This study aims to assess long-term outcomes of modified-ventral hernia working group (VHWG) grade 3 repairs. Because the relevance of hernia recurrence (HR) as the primary outcome for this patient group is contentious, the need for further hernia surgery (FHS) was also assessed in relation to long-term survival.

Methods
A retrospective cohort study with a single prospective follow-up time-point nested in a consecutive series of patients undergoing CAWR in two European national intestinal failure centers.

Results
In long-term analysis, 266 modified VHWG grade 3 procedures were included. The overall HR rate was 32.3%. The HR rates for non-crosslinked biologic meshes and synthetic meshes when fascial closure was achieved were 20.3% and 30.6%, respectively. The rates of FHS were 7.2% and 16.7%, and occurred only within the first 3 years. Bridged repairs showed poorer results (fascial closure 22.9% hernia recurrence vs bridged 57.1% recurrence). Overall survival was relatively good with 80% en 70% of the patients still alive after 5 and 10 years, respectively. In total 86.6% of the patients remained free of FHS.

Conclusions
In this study of contaminated CAWR, non-crosslinked biologic mesh shows better results than synthetic mesh. Bridging repairs with no posterior and/or anterior fascial closure have a higher recurrence rate. The overall survival was good and the majority of patients remained free of additional hernia surgery.
Pentraxin-3 is not related to disease severity in cirrhosis and hepatocellular carcinoma patients
Authors: Feder Susanne , Haberl Elisabeth M. , Spirk Marlen , Weiss Thomas S. , Wiest Reiner , Buechler Christa 
Published: February 2020

AbstractThe acute-phase protein pentraxin-3 (PTX3) is a component of the innate immune system. Inflammation and tissue injury increased PTX3 in the injured liver, and accordingly, circulating PTX3 was induced in patients with chronic liver diseases. In the present study, PTX3 protein was determined in systemic, hepatic, and portal vein plasma of patients with liver cirrhosis to assess a possible association between hepatic PTX3 release and extent of liver injury. However, PTX3 levels were not related to disease severity. Of note, portal PTX3 levels were higher than concentrations in the hepatic vein. PTX3 in the hepatic and portal veins was negatively correlated with factor V, antithrombin 3, and prothrombin time. PTX3 did neither correlate with C-reactive protein nor galectin-3 or resistin, whereby the latter two proteins are associated with hepatic injury. PTX3 levels were not changed in cirrhosis patients with ascites or varices and did not correlate with the hepatic venous pressure gradient. Likewise, serum PTX3 was not correlated with histological steatosis, inflammation, or fibrosis stage in patients with hepatocellular carcinoma (HCC). Moreover, PTX3 was not associated with tumor node metastasis classification in HCC. Above all, PTX3 increased in hepatic, portal, and systemic blood immediately after transjugular intrahepatic portosystemic shunt (TIPS). Higher PTX3 in portal than hepatic vein plasma and further increase after TIPS suggests that the liver eliminates PTX3 from the circulation. In summary, PTX3 is not of diagnostic value in cirrhosis and HCC patients.
Forschungsbereiche der Datenökonomie
Authors: Azkan Can , Goecke Henry , Spiekermann Markus 
Published: February 2020

ZusammenfassungDurch die rasant steigende Datenmenge ergeben sich viele Möglichkeiten, neue datengetriebene Geschäftsmodelle zu entwickeln. Die Datenökonomie gewinnt immer mehr an Bedeutung. Damit das ökonomische Potenzial ausgeschöpft werden kann, ist es elementar, dass genügend Fachkräfte verfügbar sind. Wichtige Forschungsbereiche der Datenökonomie sind die Bedeutung von Kooperationen und Wissen für die Entwicklung neuer Geschäftsmodelle, Daten und Algorithmen sowie das Branchencluster des Gesundheitswesens.