bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sobreposição da mutação ganho-de-função* do gen SETBP1 na Síndrome de Schinzel-Giedion e em doenças hematológicas malignas
Authors: Borges Ferreira Viviane 
Published: May 2020

A Síndrome de Schinzel-Giedion (SGS) é um raro distúrbio do desenvolvimento, caracterizado por múltiplas malformações, alterações neurológicas severas e elevação do risco de ocorrência de neoplasias malignas. SGS é causada por mutação de novo no hotspot (região do material genético mais propensa a mutação) do braço curto do cromossomo 12, no exon4, no gen SETBP1. Mutações nesse hotspot interrompem a degradação e regulação proteica, promovendo o acúmulo da proteína SETBP1. A sobreposição de mutações no hotspot do gen da proteína SETBP1 tem sido observada, de maneira recorrente em fenótipos como a leucemia. Foram coletadas informações clínicas de 47 pacientes com SGS (incluindo 26 casos novos), com mutação de células germinativas de SETBP1 e em quatro indivíduos com fenótipo moderado causado por mutação de novo adjacente ao hotspot SETBP1.
*Mutações de ganho de função são aquelas que causam a superexpressão de um produto gênico (hipermorfismo).

Publicado no PLOS Genetics. Volume 3, Issue 1, February 2017. Com o mesmo título. Autores: Rocio Acuna-Hidalgo, Pelagia Deriziotis, MarloesSteehouwer, Christian Gilissen, Sarah A. Graham, Sipko van Dam, Julie Hoover-Fong, Viviane Ferreira, et. al.
Inclusive Excellence and Underrepresentation of Students of Color in Study Abroad
Authors: Sweeney Karyn 
Published: May 2020

Students of color continue to be underrepresented in terms of study abroad participation. Inclusive excellence shifts diversity efforts from a focus on numbers to a comprehensive examination of systems and the ways in which the contributions of all community members are recognized, enhanced, and facilitated (Milem, Chang, & Antonio, 2005). The concept of inclusive excellence and the inclusive excellence scorecard are tools that can be utilized by international educators to examine the participation of students of color in study abroad within our own institutions, to evaluate efforts to resolve underrepresentation, and to inform best practices to support all students throughout the study abroad process. The inclusive excellence scorecard, modified for study abroad, examines access and equity, campus climate, diversity in the formal and informal curriculum, and learning and development. Until institutions have a clear understanding of the experiences, challenges, and opportunities on their own campuses and study abroad programs, they cannot effectively create change to better serve students of color and impact underrepresentation.
College Students’ Sexual Orientation, Gender Identity, and Participation in Study Abroad
Authors: Bryant Kelly M. , Soria Krista M. 
Published: May 2020

In recent years, there has been an increase in the number of students studying abroad; however, researchers have discovered that some student populations are not as likely to study abroad, including students with disabilities, multicultural students, and low-income students. Amid these growing bodies of literature that highlight disparities between students’ participation in study abroad, research fails to address whether lesbian, gay, bisexual, transgender, questioning or queer students (LGBTQQ) study abroad at lower rates than their peers given that some cultures are not accepting of students’ sexual orientation or transgender identities. This lack of research is troubling because LGBTQQ students face challenges many of their peers do not normally have to confront in higher education. The purpose of this study, then, is to fill this gap in research by answering the following question: are LGBTQQ students significantly less likely to study abroad compared to their peers? Utilizing student data from the multi-institutional Student Experience in the Research University (SERU) survey, the results of this study suggest that LGBTQQ students are significantly more likely than heterosexual and cisgender students to participate in study abroad opportunities in several areas
Evaluating the Study Abroad Experience using the framework of Rotter’s Social Learning Theory
Authors: McLeod Mark , Carter Vince , Nowicki Steve , Tottenham Dana , Wainwright Philip , Wyner Dana 
Published: May 2020

The authors proposed a framework based on Rotter’s Social Learning Theory (SLT) that is appropriate for the evaluation of students’ experiences in college study abroad programs (McLeod & Wainwright, 2009). In the present paper two concepts originating in SLT, locus of control and self- esteem, were used to gauge the impact of study abroad courses on undergraduates. It was predicted and found that when compared to a peer comparison group, study abroad participants became more internally controlled; however there was no change in self-esteem. It was important to note that the study abroad students maintained the positive change in locus of control six months after the end of the program. Rotter’s SLT appears to be a viable perspective for examining significant aspects of the study abroad experience.
PENERAPAN METODE MMP DAN NHT TERHADAP HASIL BELAJAR MATEMATIKA PADA MATERI TRIGONOMETRI
Authors: Budiyanti Erni , Kusuma Arie Purwa , Arihati Desy Bangkit 
Published: May 2020

Penelitian ini diharapkan dapat membuktikan perbedaan hasil belajar matematika siswa yang diajar dengan menggunakan metode Missouri Mathematics Problem (MMP) dan Numbered Head Together (NHT) pada materi trigonometri. Penelitian ini dilaksanakan pada bulan Maret sampai April 2018, dengan metode eksperimen. Sampel dari penelitian ini berjumlah 72 siswa, 36 siswa di kelas X Elektro 2 yang menggunakan metode Missouri Mathematics Project (MMP) dan 36 siswa di kelas X Elektro 1 yang menggunakan metode Numbered Head Together (NHT), pemilihan sampel penelitian secara cluster random sampling. Instrumen yang digunakan dalam penelitian ini adalah soal tes materi trigonometri berbentuk soal pilihan ganda, dari hasil ujicoba tes yang valid 25 soal dengan menggunakan reliabilitas Kuder Richardson (KR-20) diperoleh 0,9147. Berdasarkan perhitungan diperoleh data bahwa rata-rata hasil belajar siswa melalui metode Missouri Mathematics Project (MMP) memiliki rata-rata 76,5 dan rata-rata hasil belajar siswa melalui metode Numbered Head Together (NHT) memiliki rata-rata 71,33. Dalam uji prasyarat kedua data berdistribusi normal dan homogen. Pengujian hipotesis data diperoleh thitung = 2,068 > ttabel = 1,994. Maka diperoleh kesimpulan H1 diterima dan H0 ditolak. Dengan demikian kesimpulan penelitian ini adalah terdapat perbedaan hasil belajar matematika siswa yang menggunakan metode Missouri Mathematics Project (MMP) dan metode Numbered Head Together (NHT) pada materi Trigonometri di kelas X.
PENGARUH PENDEKATAN SAINTIFIK TERHADAP KEMAMPUAN BERPIKIR KRITIS MAHASISWA
Authors: Yudha Chrisnaji Banindra 
Published: May 2020

Penelitian ini adalah penelitian kuantitatif dengan jenis true experimental design dengan model desain pretest-posttest control group design. Penelitian ini dilaksanakan di Prodi PGSD Semester ganjil 2018/2019 pada mata kuliah pendidikan matematika SD 2. Populasi dalam penelitian ini adalah 60 Mahasiwa. Sampel yang digunakan dalam penelitian ini adalah 40 siswa, 20 siswa untuk kelas eksperimen dan 20 siswa untuk kelas kontrol. Instrument penelitian ini menggunakan tes kemampuan berpikir kritis dan lembar observasi untuk guru dan siswa yang masing-masing telah divalidasi oleh ekpert judgement. Data yang diperoleh dianalisis dengan uji normalitas dan uji homogenitas kemudian dilanjutkan dengan uji hipotesis menggunakan uji-t. Hasil penelitian menunjukkan bahwa: (1) Penerapan pendekatan saintifik terhadap kemampuan berpikir kritis mahasiswa mengalami peningkatan secara berkelanjutan dengan kategori penilaian baik. (2) kemampuan berpikir kritis berimbas pada Hasil belajar matematika setelah diterapkan pendekatan saintifik dengan kategori tinggi. Begitu juga pada kelas yang menerapkan metode pembelajaran konvensional, juga mengalami peningkatan hasil belajar akan tetapi peningkatannya dengan kategori sedang. (3) Ada pengaruh positif dan signifikan penerapan pendekatan saintifik terhadap kemampuan berpikir kritis mahasiswa PGSD STKIP Kusuma Negara Semester Ganjil 2018/2019.
Pengaruh Kualitas Layanan, Relational Bonding, dan Brand Image Terhadap Loyalitas Nasabah
Authors: Prihatiningsih Endang , Estiasih Soffia Pudji 
Published: May 2020

In today's banking industry experienced sharp competition, which requires BRI banks to improve their performance, among others, by improving the services quality is one key to business success. Besides the BRI banks must maintain a brand image that is good in the eyes of their customers, and continue to establish harmonious long-term relationships with its customers so that customers remain loyal to the BRI Bank Branch of Jombang. This study aims to test and analyze relationships partially or simultaneously service quality, relational bonding and brand image of customer loyalty BRI Bank Branch of Jombang. While the population in this study all customers of BRI Bank Branch of Jombang and the sample of this study was 90 with sampling techniques that were accidental sampling that is customers who easily found and willing to fill out the questionnaire that the author proposed. The analysis technique uses multiple linear regression analysis with SPSS Version 20.0. The results of partial hypothesis test is 1) service quality not significant effect on customer loyalty with sig. = 0.817 > 0.05 so the hypothesis is rejected; 2) relational bonding significant effect on customer loyalty with sig. = 0.003 < 0.05, so the hypothesis is accepted; 3) brand image significant effect on customer loyalty with sig. = 0.001 < 0.05 so the hypothesis is accepted. The results of simultaneously is service quality, relational bonding and brand image have a significant effect on customer loyalty with Sig. = 0.000 < 0.05 so the hypothesis is accepted.
Peranan Intellectual Capital pada Intermediary Function Terhadap Return on Equity Perusahaan Perbankan
Authors: Permatasari Anita 
Published: May 2020

This study aims to examine the role of Intellectual Capital in banking companies listed on the Indonesia Stock Exchange. The research data used are secondary data in the form of financial data and financial ratios of banks listed on the Indonesia Stock Exchange from 2010 to 2016 using the purposive sampling method. Based on sampling criteria, 23 banks were selected and divided into two categories: banks with low Intellectual Capital and banks with high Intellectual Capital. The results showed that there were three findings, namely the first test results on banks with low Intellectual Capital and high Intellectual Capital showed that Non Performing Loans (NPL), Operational Costs Per Operating Income (BOPO), Loan to Deposit Ratio (LDR), and Capital Adequacy Ratio (CAR) does not affect Return on Equity (ROE). Second, the results of testing on banks with low Intellectual Capital and high Intellectual Capital indicate that Non Performing Loans (NPL), Loan to Deposit Ratio (LDR), and Capital Adequacy Ratio (CAR) have no effect on Return on Equity (ROE). Third, the results of testing on banks with high Intellectual Capital indicate that Operational Cost Per Operational Income (BOPO) has an effect on Return on Equity (ROE).
Neutral Iron Emission Lines from the Dayside of KELT-9b: The GAPS Program with HARPS-N at TNG XX
Authors: Pino Lorenzo , Désert Jean-Michel , Brogi Matteo , Malavolta Luca , Wyttenbach Aurélien , Line Michael , Hoeijmakers Jens , Fossati Luca , Bonomo Aldo Stefano , Nascimbeni Valerio , Panwar Vatsal , Affer Laura , Benatti Serena , Biazzo Katia , Bignamini Andrea , Borsa Franscesco , Carleo Ilaria , Claudi Riccardo , Cosentino Rosario , Covino Elvira , Damasso Mario , Desidera Silvano , Giacobbe Paolo , Harutyunyan Avet , Lanza Antonino Francesco , Leto Giuseppe , Maggio Antonio , Maldonado Jesus , Mancini Luigi , Micela Giuseppina , Molinari Emilio , Pagano Isabella , Piotto Giampaolo , Poretti Ennio , Rainer Monica , Scandariato Gaetano , Sozzetti Alessandro , Allart Romain , Borsato Luca , Bruno Giovanni , Fabrizio Luca Di , Ehrenreich David , Fiorenzano Aldo , Frustagli Giuseppe , Lavie Baptiste , Lovis Christophe , Magazzù Antonio , Nardiello Domenico , Pedani Marco , Smareglia Riccardo 
Published: May 2020

Abstract
We present the first detection of atomic emission lines from the atmosphere of an exoplanet. We detect neutral iron lines from the dayside of KELT-9b (T
eq ∼ 4000 K). We combined thousands of spectrally resolved lines observed during one night with the HARPS-N spectrograph (R ∼ 115,000), mounted at the Telescopio Nazionale Galileo. We introduce a novel statistical approach to extract the planetary parameters from the binary mask cross-correlation analysis. We also adapt the concept of contribution function to the context of high spectral resolution observations, to identify the location in the planetary atmosphere where the detected emission originates. The average planetary line profile intersected by a stellar G2 binary mask was found in emission with a contrast of 84 ± 14 ppm relative to the planetary plus stellar continuum (40% ± 5% relative to the planetary continuum only). This result unambiguously indicates the presence of an atmospheric thermal inversion. Finally, assuming a modeled temperature profile previously published, we show that an iron abundance consistent with a few times the stellar value explains the data well. In this scenario, the iron emission originates at the 10−3–10−5 bar level.
A Neve das PalAVRAS
Authors: Cantinho Maria João 
Published: May 2020

Este artigo quer ler a vida de Paul Pessakh Antschel – nome verdadeiro de Celan. Paul Antschel muda o seu nome de Antschel para o anagrama Celan, que viria a conservar ao longo de toda a sua vida. As leituras de Marx e Nietszche, a par da poesia alemã, sobretudo Hölderlin e Rilke, mas também Goethe e Schiller, Heine, Trakl, Kafka, Hofmannsthal, entre outros, desenvolveram no poeta um gosto pela política e simultaneamente pela literatura. Música e morte entretecem-se, na poesia de Celan, evocando a atmosfera lírica de Schubert – A Morte e a Donzela - ou de Mahler, de Brahms e do Requiem Alemão, numa tentativa de harmonizar a mais dolorosa e insustentável vivência. Celebração, não da morte, mas daqueles que pereceram nos campos de morte, sob as condições mais desumanas que é possível imaginar-se e a dilaceração surge, de forma sublime, no poema “Fuga da Morte”. No poema “A morte é uma flor”, Celan alegoriza a morte através da imagem de uma flor, uma flor que “só abre uma vez”. Trata-se de um mundo de uma beleza terrível, onde os mortos “brotam e florescem”. Morrem para a vida, florescendo para a linguagem poética, a única capaz de resgatar a experiência do horror, pela via da rememoração. Rememorar a experiência vivida deve ser entendido como o gesto que simultaneamente leva a cabo a destruição dos elos orgânicos e, contrariamente, encerra em si uma pretensão redentora, essa a verdadeira finalidade da poesia de Celan.
Algumas reflexões sobre a definição de probabilidade
Authors: Pereira André Gustavo Campos , Cortes George Luiz Coelho , Medeiros George Homer Barbosa de , Almeida Fernando Montanaro Paiva de , Almeida Júnior Francisco Erivan de , Nunes Igor Bruno Dantas , Silva Arthur Henrique da , Souza Gleydson Medeiros de 
Published: May 2020

Todos os dias nos deparamos com situações em que precisamos fazer escolhas. Algumas escolhas são bem simples como por exemplo, se você deseja ou não tomar um sorvete, se decidir por tomar, se vai querer que seja servido no copo ou numa casquinha, e depois ainda tem que escolher o(s) sabor(es). Em algumas destas escolhas temos preferências e em outras somos indiferentes (temos a mesma preferência para qualquer escolha). Se mesmo em casos simples vemos que a indiferença não é a regra, porque no estudo de probabilidade o foco é na indiferença (equiprobabilidade)? Este trabalho constata através da análise de livros, dissertações de mestrado bem como do resultado do teste aplicado com alunos, que o conceito de probabilidade sedimentado é aquele que nos obriga a aceitar a equiprobabilidade como a única forma de ver o mundo e que muito pouco tem sido feito recentemente para mudar esse quadro. Também relatamos que a forma como alguns compêndios tratam o tema pode dificultar o entendimento até mesmo do caso em que a equiprobabilidade é considerada.
¿Cómo se relacionan los jóvenes con los saberes artísticos dentro y fuera de la escuela?
Authors: González Vida María Reyes , Marcellán Baraze Idoia , Arriaga Amaia 
Published: May 2020

En este artículo se presenta el estudio de caso de cómo dos jóvenes ponen en juego una serie de saberes artísticos para producir cultura visual dentro y fuera de la escuela. Este análisis se contrasta y amplía con los resultados extraídos de un cuestionario pasado a 786 jóvenes españoles de 14 a 18 años que indaga sobre su actividad como productores de cultura visual en ambos entornos. Entre las conclusiones destaca el hecho de que los saberes no puramente escolares tienen gran importancia en las producciones visuales de los jóvenes y se subraya el valor formativo de los espacios no escolares para estos jóvenes.

Revisión
Vanessa Freitag
Jazykové potřeby zahraničních lékařů pracujících v českých nemocnicích
Authors: Cvejnová Jitka 
Published: May 2020

Vedle zahraničních lékařů, kteří vystudovali v ČR lékařské obory, působí nyní v České republice zahraniční lékaři, kteří zde nestudovali především ze zemí bývalého Sovětského svazu. Tito lékaři musí jednak zvládnout lékařskou praxi v nemocnicích, jednak náročné aprobační zkoušky České lékařské komory. Nezbytnou součástí jejich pracovního úspěchu je ovládnutí poměrně rozsáhlé škály řečových dovedností v češtině. Cílem příspěvku je analyzovat jazykové potřeby těchto lékařů v jednotlivých řečových dovednostech pomocí deskriptorů a představit jednotlivé deskriptory tak, aby je bylo možné využít pro tvorbu tzv. modelových scénářů pro výuku lékařů, a to i s ohledem na skutečnost, že se v poslední době výuka podle modelových scénářů prosazuje jako jedna ze základních metod výuky jazyka v pracovní oblasti.
Rozvíjanie relevantnej lexikálnej kompetencie u študentov medicíny na hodinách slovenčiny
Authors: Haláková Milota , Kšiňanová Marína 
Published: May 2020

V príspevku vychádzame zo skúseností výučby slovenčiny na Lekárskej fakulte UK v Bratislave. Výučba slovenčiny je v tom to prostredí vnímaná predovšetkým ako prostriedok odbornej komunikácie pri štúdiu medicíny. Metódy rozvíjania relevantnej lexiky budeme prezentovať prostredníctvom učebných materiálov z pripravovaných konverzačných učebníc: Slovenčina ako liek a Slovenčina ako diagnóza. Cieľom príspevku je ukázať praktické možnosti nadobúdania odborných lexikálnych kompetencií. Na slovo nepozeráme ako na samostatnú lexikálnu jednotku, slovo prezentujeme v kontexte a v danej situácii, kde nadobúda svoj špecifický význam. Naším zámerom je odhaliť možnosti porozumenia významu slov na základe kontextu, ukázať možnosti využitia slovotvornej motivácie, slovných asociácií a väzieb, zamerať sa na vizuálnu pamäť študentov, prezentovať možnosti situačného a komunikatívneho spôsobu učenia lexiky.
fRNAkenseq: a fully powered-by-CyVerse cloud integrated RNA-sequencing analysis tool
Authors: Hubbard Allen , Bomhoff Matthew , Schmidt Carl J. 
Published: May 2020

Background
Decreasing costs make RNA sequencing technologies increasingly affordable for biologists. However, many researchers who can now afford sequencing lack access to resources necessary for downstream analysis. This means that even as algorithms to process RNA-Seq data improve, many biologists still struggle to manage the sheer volume of data produced by next generation sequencing (NGS) technologies. Scalable bioinformatics tools that exploit multiple platforms are needed to democratize bioinformatics resources in the sequencing era. This is essential for equipping many research groups in the life sciences with the tools to process the increasingly unwieldy datasets they produce.

Methods
One strategy to address this challenge is to develop a modern generation of sequence analysis tools capable of seamless data sharing and communication. Such tools will provide interoperability through offerings of interlinked resources. Systems of interlinked, scalable resources, which often incorporate cloud data storage, are broadly referred to as cyberinfrastructure. Cyberinfrastructure integrated tools will help researchers to robustly analyze large scale datasets by efficiently sharing data burdens across a distributed architecture. Additionally, interoperability will allow emerging tools to cross-adapt features of existing tools. It is important that these tools are designed to be easy to use for biologists.

Results
We introduce fRNAkenseq, a powered-by-CyVerse RNA sequencing analysis tool that exhibits interoperability with other resources and meets the needs of biologists for comprehensive, easy to use RNA sequencing analysis. fRNAkenseq leverages a complex set of Application Programming Interfaces (APIs) associated with the NSF-funded cyberinfrastructure project, CyVerse, to execute FASTQ-to-differential expression RNA-Seq analyses. Integrating across bioinformatics platforms, fRNAkenseq also exploits cloud integration and cross-talk with another CyVerse associated tool, CoGe. fRNAkenseq offers novel features for the biologist such as more robust and comprehensive pipelines for enrichment than those currently available by default in a single tool, whether they are cloud-based or local installation. Importantly, cross-talk with CoGe allows fRNAkenseq users to execute RNA-Seq pipelines on an inventory of 47,000 archived genomes stored in CoGe or upload their own draft genome.
Drivers of beta diversity in modern and ancient reef-associated soft-bottom environments
Authors: Roden Vanessa Julie , Zuschin Martin , Nützel Alexander , Hausmann Imelda M. , Kiessling Wolfgang 
Published: May 2020

Beta diversity, the compositional variation among communities, is often associated with environmental gradients. Other drivers of beta diversity include stochastic processes, priority effects, predation, or competitive exclusion. Temporal turnover may also explain differences in faunal composition between fossil assemblages. To assess the drivers of beta diversity in reef-associated soft-bottom environments, we investigate community patterns in a Middle to Late Triassic reef basin assemblage from the Cassian Formation in the Dolomites, Northern Italy, and compare results with a Recent reef basin assemblage from the Northern Bay of Safaga, Red Sea, Egypt. We evaluate beta diversity with regard to age, water depth, and spatial distance, and compare the results with a null model to evaluate the stochasticity of these differences. Using pairwise proportional dissimilarity, we find very high beta diversity for the Cassian Formation (0.91 ± 0.02) and slightly lower beta diversity for the Bay of Safaga (0.89 ± 0.04). Null models show that stochasticity only plays a minor role in determining faunal differences. Spatial distance is also irrelevant. Contrary to expectations, there is no tendency of beta diversity to decrease with water depth. Although water depth has frequently been found to be a key factor in determining beta diversity, we find that it is not the major driver in these reef-associated soft-bottom environments. We postulate that priority effects and the biotic structuring of the sediment may be key determinants of beta diversity.