bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altering potato isoprenoid metabolism increases biomass and induces early flowering
Authors: Moehninsi  , Lange Iris , Lange B Markus , Navarre Duroy A 
Published: April 2020

AbstractIsoprenoids constitute the largest class of plant natural products and have diverse biological functions including in plant growth and development. In potato (Solanum tuberosum), the regulatory mechanism underlying the biosynthesis of isoprenoids through the mevalonate pathway is unclear. We assessed the role of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) homologs in potato development and in the metabolic regulation of isoprenoid biosynthesis by generating transgenic lines with down-regulated expression (RNAi-hmgr) or overexpression (OE) of one (StHMGR1 or StHMGR3) or two genes, HMGR and farnesyl diphosphate synthase (FPS; StHMGR1/StFPS1 or StHMGR3/StFPS1). Levels of sterols, steroidal glycoalkaloids (SGAs), and plastidial isoprenoids were elevated in the OE-HMGR1, OE-HMGR1/FPS1, and OE-HMGR3/FPS1 lines, and these plants exhibited early flowering, increased stem height, increased biomass, and increased total tuber weight. However, OE-HMGR3 lines showed dwarfism and had the highest sterol amounts, but without an increase in SGA levels, supporting a rate-limiting role for HMGR3 in the accumulation of sterols. Potato RNAi-hmgr lines showed inhibited growth and reduced cytosolic isoprenoid levels. We also determined the relative importance of transcriptional control at regulatory points of isoprenoid precursor biosynthesis by assessing gene–metabolite correlations. These findings provide novel insights into specific end-products of the sterol pathway and could be important for crop yield and bioenergy crops.
Recovering and rendering silenced experiences of genocides: Testimonial fragments of the Holocaust
Authors: Mihály Tóth Gábor 
Published: April 2020

Abstract
The experiences of murdered victims of Nazi persecutions perished with them. This article discusses how text and data mining technology has helped to recover fragments of these lost experiences out of 2,500 oral history interviews with survivors. This gave rise to Let them Speak, a data edition of Holocaust testimonies. The first part situates the challenge of revealing lost experiences in historiography, and argues that the experience of murdered victims can be reconstructed through the collective experience. The second part shows how text and data mining techniques assisted the author to identify some pieces of the collective experience. The third part presents how web technology and visualization are used to render pieces of the collective experience as testimonial fragments of the Holocaust.
An Example of 3-D Printing for Expeditionary Medicine: The Air Force Retractor
Authors: Chambers James A , Seastedt Kenneth P , Raymundo-Grinstead Jocelyn 
Published: April 2020

Abstract

Introduction
Future challenges for the U.S. Department of Defense (DoD) include operating in a contested environment against near-peer adversaries. Providing casualty care in an anti-access/area denial (A2/AD) region would be potentially challenged by impaired logistical ability to reconstitute supplies or adapt to evolving needs. Additive manufacturing (AM), also known as 3D printing, offers an ability to regenerate stocked items as well as modify them or even create novel products de novo.

Materials and Methods
This article discusses relevant technology and applications for deployed medical forces. Additionally, as proof of concept, we outline our design process for a novel 3D-printed surgical retractor.

Results
Our “Air Force Retractor” prototype highlights the potential of using AM to create or augment surgical instruments downrange.

Conclusions
This paper encourages further investigation of the use of AM/3D printing downrange to create surgical instruments and medical supplies in austere, A2/AD, and other logistically challenging environments. Not only would this support regeneration of supplies, but also modification and even creation of novel products to adapt to changing needs. If 3D files could be created of common surgical instruments for print on designated resins downrange, and FDA approval obtained, an online library of files could be created for easy access to DoD members across the globe to support our nation’s commitment to provide the best possible care for service members any time, any place.
Epidemiology of visceral mycoses in patients with acute leukemia and myelodysplastic syndrome: Analyzing the national autopsy database in Japan
Authors: Togano Tomiteru , Suzuki Yuhko , Nakamura Fumihiko , Tse William , kume Hikaru 
Published: April 2020

AbstractVisceral mycoses (VM) are a deadly common infection in patients with acute leukemia and myelodysplastic syndrome (MDS). We retrospectively analyzed the data from the centralized “Annual Report of Autopsy Cases in Japan” that archives the national autopsy cases since 1989. Among the total of 175,615 archived autopsy cases, 7183 cases (4.1%) were acute leukemia and MDS patients. While VM was only found in 7756 cases (4.4% in total cases), we found VM had a disproportionally high prevalence among acute leukemia and MDS patients: 1562 VM cases (21.7%) and nearly sixfold higher in prevalence. Aspergillus spp. was the most predominant causative agent (45.0%), and Candida spp. was the second (22.7%) among confirmed single pathogen involved cases. The prevalence of Candida spp. infection decreased about 50% due to the widely use of fluconazole prophylaxis, which may skew toward doubling of the Mucormycetes incidence compared to 30 years ago. Complicated fungal infection (&gt; one pathogen) was 11.0% in acute leukemia and MDS in 2015. It was 14.7 times higher than in other populations. Among 937 patients who received allogeneic hematopoietic cell transplantation (HCT), the prevalence of VM was 28.3% and 23.3% with GVHD. Aspergillus spp. was less prevalent, but Candida spp. was more associated with GVHD. Its prevalence remains stable. Although Aspergillus spp. was the primary causative agent, non-albicans Candida spp. was increasing as a breakthrough infection especially in GVHD cases. Complicated pathogen cases were more common in acute leukemia and MDS.
Galaxy formation with BECDM – II. Cosmic filaments and first galaxies
Authors: Mocz Philip , Fialkov Anastasia , Vogelsberger Mark , Becerra Fernando , Shen Xuejian , Robles Victor H , Amin Mustafa A , Zavala Jesús , Boylan-Kolchin Michael , Bose Sownak , Marinacci Federico , Chavanis Pierre-Henri , Lancaster Lachlan , Hernquist Lars 
Published: April 2020

ABSTRACT
Bose–Einstein condensate dark matter (BECDM, also known as fuzzy dark matter) is motivated by fundamental physics and has recently received significant attention as a serious alternative to the established cold dark matter (CDM) model. We perform cosmological simulations of BECDM gravitationally coupled to baryons and investigate structure formation at high redshifts (z ≳ 5) for a boson mass m = 2.5 × 10−22 eV, exploring the dynamical effects of its wavelike nature on the cosmic web and the formation of first galaxies. Our BECDM simulations are directly compared to CDM as well as to simulations where the dynamical quantum potential is ignored and only the initial suppression of the power spectrum is considered – a warm dark matter-like (‘WDM’) model often used as a proxy for BECDM. Our simulations confirm that ‘WDM’ is a good approximation to BECDM on large cosmological scales even in the presence of the baryonic feedback. Similarities also exist on small scales, with primordial star formation happening both in isolated haloes and continuously along cosmic filaments; the latter effect is not present in CDM. Global star formation and metal enrichment in these first galaxies are delayed in BECDM/‘WDM’ compared to the CDM case: in BECDM/‘WDM’ first stars form at z ∼ 13/13.5, while in CDM star formation starts at z ∼ 35. The signature of BECDM interference, not present in ‘WDM’, is seen in the evolved dark matter power spectrum: although the small-scale structure is initially suppressed, power on kpc scales is added at lower redshifts. Our simulations lay the groundwork for realistic simulations of galaxy formation in BECDM.
Extensive Ethnolinguistic Diversity in Vietnam Reflects Multiple Sources of Genetic Diversity
Authors: Liu Dang , Duong Nguyen Thuy , Ton Nguyen Dang , Van Phong Nguyen , Pakendorf Brigitte , Van Hai Nong , Stoneking Mark 
Published: April 2020

Abstract
Vietnam features extensive ethnolinguistic diversity and occupies a key position in Mainland Southeast Asia. Yet, the genetic diversity of Vietnam remains relatively unexplored, especially with genome-wide data, because previous studies have focused mainly on the majority Kinh group. Here, we analyze newly generated genome-wide single-nucleotide polymorphism data for the Kinh and 21 additional ethnic groups in Vietnam, encompassing all five major language families in Mainland Southeast Asia. In addition to analyzing the allele and haplotype sharing within the Vietnamese groups, we incorporate published data from both nearby modern populations and ancient samples for comparison. In contrast to previous studies that suggested a largely indigenous origin for Vietnamese genetic diversity, we find that Vietnamese ethnolinguistic groups harbor multiple sources of genetic diversity that likely reflect different sources for the ancestry associated with each language family. However, linguistic diversity does not completely match genetic diversity: There have been extensive interactions between the Hmong-Mien and Tai-Kadai groups; different Austro-Asiatic groups show different affinities with other ethnolinguistic groups; and we identified a likely case of cultural diffusion in which some Austro-Asiatic groups shifted to Austronesian languages during the past 2,500 years. Overall, our results highlight the importance of genome-wide data from dense sampling of ethnolinguistic groups in providing new insights into the genetic diversity and history of an ethnolinguistically diverse region, such as Vietnam.
The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt–PCAF pathway in promotion of esophageal squamous cell carcinoma growth
Authors: Wu Yue , Wang Xue , Xu Feifei , Zhang Lu , Wang Tianjiao , Fu Xueli , Jin Tianzhi , Zhang Weiying , Ye Lihong 
Published: April 2020

Abstract
High-mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that plays essential roles in embryonic development and cancer progression. However, the mechanism of HMGA2 regulation remains largely uncharacterized. Here, we demonstrate that HMGA2 can be modulated by hepatitis B X-interacting protein (HBXIP), an oncogenic transcriptional coactivator, in esophageal squamous cell carcinoma (ESCC). HMGA2 expression was positively associated with HBXIP expression in clinical ESCC tissues, and their high levels were associated with advanced tumor stage and reduced overall and disease-free survival. We found that oncogenic HBXIP could posttranslationally upregulate HMGA2 protein level in ESCC cells. HBXIP induced HMGA2 acetylation at the lysine 26 (K26), resulting in HMGA2 protein accumulation. In this process, HBXIP increased the acetyltransferase p300/CBP-associated factor (PCAF) phosphorylation and activation via the Akt pathway, then PCAF directly interacted with HMGA2, leading to HMGA2 acetylation in the cells. HMGA2 K26 acetylation enhanced its DNA binding capacity and blocked its ubiquitination and then inhibited proteasome-dependent degradation. Functionally, HBXIP-stabilized HMGA2 could promote ESCC cell growth in vitro and in vivo. Strikingly, aspirin suppressed ESCC growth by inhibiting HBXIP and HMGA2. Collectively, our findings disclose a new mechanism for the posttranslational regulation of HMGA2 mediated by HBXIP in ESCC.
A multiple-response frequency-tagging paradigm measures graded changes in consciousness during perceptual filling-in
Authors: Davidson Matthew J , Graafsma Irene L , Tsuchiya Naotsugu , van Boxtel Jeroen 
Published: April 2020

Abstract
Perceptual filling-in (PFI) occurs when a physically present visual target disappears from conscious perception, with its location filled-in by the surrounding visual background. These perceptual changes are complete, near instantaneous, and can occur for multiple separate locations simultaneously. Here, we show that contrasting neural activity during the presence or absence of multi-target PFI can complement other findings from multistable phenomena to reveal the neural correlates of consciousness (NCC). We presented four peripheral targets over a background dynamically updating at 20 Hz. While participants reported on target disappearances/reappearances via button press/release, we tracked neural activity entrained by the background during PFI using steady-state visually evoked potentials (SSVEPs) recorded in the electroencephalogram. We found background SSVEPs closely correlated with subjective report, and increased with an increasing amount of PFI. Unexpectedly, we found that as the number of filled-in targets increased, the duration of target disappearances also increased, suggesting that facilitatory interactions exist between targets in separate visual quadrants. We also found distinct spatiotemporal correlates for the background SSVEP harmonics. Prior to genuine PFI, the response at the second harmonic (40 Hz) increased before the first (20 Hz), which we tentatively link to an attentional effect, while no such difference between harmonics was observed for physically removed stimuli. These results demonstrate that PFI can be used to study multi-object perceptual suppression when frequency-tagging the background of a visual display, and because there are distinct neural correlates for endogenously and exogenously induced changes in consciousness, that it is ideally suited to study the NCC.
Vacuum energy of the supersymmetric $\mathbb{C}P^{N-1}$ model on $\mathbb{R}\times S^1$ in the $1/N$ expansion
Authors: Ishikawa Kosuke , Okuto Morikawa , Shibata Kazuya , Suzuki Hiroshi 
Published: April 2020

Abstract
By employing the $1/N$ expansion, we compute the vacuum energy $E(\delta\epsilon)$ of the two-dimensional supersymmetric (SUSY) $\mathbb{C}P^{N-1}$ model on $\mathbb{R}\times S^1$ with $\mathbb{Z}_N$ twisted boundary conditions to the second order in a SUSY-breaking parameter $\delta\epsilon$. This quantity was vigorously studied recently by Fujimori et al. using a semi-classical approximation based on the bion, motivated by a possible semi-classical picture on the infrared renormalon. In our calculation, we find that the parameter $\delta\epsilon$ receives renormalization and, after this renormalization, the vacuum energy becomes ultraviolet finite. To the next-to-leading order of the $1/N$ expansion, we find that the vacuum energy normalized by the radius of the $S^1$, $R$, $RE(\delta\epsilon)$ behaves as inverse powers of $\Lambda R$ for $\Lambda R$ small, where $\Lambda$ is the dynamical scale. Since $\Lambda$ is related to the renormalized ’t Hooft coupling $\lambda_R$ as $\Lambda\sim e^{-2\pi/\lambda_R}$, to the order of the $1/N$ expansion we work out, the vacuum energy is a purely non-perturbative quantity and has no well-defined weak coupling expansion in $\lambda_R$.
The Essentials of the Helping Relationship between Social Workers and Clients
Authors: Sinai-Glazer Hagit 
Published: April 2020

AbstractThe helping relationship between a client and a practitioner is often described as the heart and soul in social work. This research explored the helping relationship between social workers and clients (the clients were mothers) in the context of public social services in Israel. The results presented here are part of a larger ethnographic study that included interviews with 14 social workers, 20 mothers who are clients, and extensive participant observations and textual analysis. Presented in this article are the results pertaining to the essential elements of the helping relationship as perceived by the research participants. Social workers and clients pointed to similar elements that comprise a good helping relationship: love and support; trust and feeling safe; listening and feeling understood; making an effort to help; humanness, compassion, and sensitivity; availability, continuity, and being there when needed; and chemistry. Participants’ accounts exemplify the importance and centrality of the helping relationship in social work. The article concludes with a discussion of the study’s implications for practice, policy, and research.
Developing external threats to offshore trusts: unexplained wealth orders and forfeiture of assets under the Forfeiture of Assets (Civil Proceedings) (Jersey) Law 2018
Authors: Alexander Stephen , Cook Mathew 
Published: April 2020

Abstract
In recent years, authorities’ toolkits have been growing with alternative methods to tackle corruption and money laundering, enabling them to attack assets held within onshore and offshore trusts. Two new tools being utilised in this regard are unexplained wealth orders (UWOs) and the non-conviction confiscation regime under the Forfeiture of Assets (Civil Proceedings) (Jersey) Law 2018 (FoAL 2018). Both may affect trusts established in Jersey. Cases have now come before the courts, testing the scope of each of these mechanisms and providing an insight into the courts’ approach to combatting financial crime by way of civil proceedings. The use of a UWO was challenged in the recent English Court of Appeal case of National Crime Agency v Hajiyeva1 and the AG v Ellis proceedings2 in Jersey involved the application of the FoAL 2018. We consider each of these mechanisms and the cases involved in turn below and discuss the impact of these developing tools on the Jersey trust industry.
Changes in Pain and Psychosocial Functioning and Transition to Chronic Pain in Pediatric Sickle Cell Disease
Authors: Sil Soumitri , Cohen Lindsey L. , Bakshi Nitya , Watt Amanda , Hathaway Morgan , Abudulai Farida , Dampier Carlton 
Published: April 2020

Objectives:This study aimed to: (1) examine changes in pain, psychosocial functioning, and health care utilization among children and adolescents with sickle cell disease (SCD) over a 2-year period and (2) identify baseline biopsychosocial variables associated with the development and maintenance of chronic SCD pain at follow-up.Materials and Methods:Forty-two youth (8 to 18 y old) with SCD completed a battery of self-report measures at baseline and 2-year follow-up. Analgesic, Anesthetic, and Addiction Clinical Trial Translational Innovations Opportunities and Networks and American Pain Society Pain Taxonomy (AAPT) diagnostic criteria were used to categorize patients into pain frequency groups at both timepoints: chronic (pain on most [≥15] d/mo for the past 6 mo, per AAPT diagnostic criteria), episodic (pain on 1 to 14 d/mo), or asymptomatic (0 d/mo).Results:At baseline, 31% (n=13) had chronic pain, 50% (n=21) episodic pain, and 19% (n=8) were asymptomatic. At follow-up, 40.5% (n=17) had chronic pain, 52.4% (n=22) episodic pain, and 7.1% (n=3) were asymptomatic. Between baseline and 2-year follow-up, 12% (n=5) developed chronic SCD pain. Depressive symptoms and admissions for pain significantly increased over time for youth with chronic pain (Ps<0.05). An interaction effect revealed that baseline pain groups differed in their change in pain intensity over time (P<0.01). Baseline psychosocial factors (ie, higher functional disability, greater depressive symptoms, higher pain catastrophizing, and lower quality of life) were significantly associated with chronic pain at follow-up.Discussion:Biopsychosocial factors may be associated with the development and maintenance of chronic SCD pain and their relative contributions warrant further study.
Do Levels of Stress Markers Influence the Retinal Nerve Fiber Layer Thickness in Young Adults?
Authors: Lee Samantha Sze-Yee , Sanfilippo Paul G. , Yazar Seyhan , Pennell Craig E. , Hewitt Alex W. , Wang Carol A. , Martin Wrivu N. , Mackey David A. 
Published: April 2020

Precis:
Although mental or emotional stress may result raise in intraocular pressure (IOP) we found weak associations between endogenous stress markers concentrations and retinal nerve fiber layer (RNFL) thickness, thus limited evidence that stress affects retinal ganglion cells integrity.

Purpose:
Increased exposure to glucocorticoids is linked to elevated IOP, which is a risk factor for glaucoma. We explored the RNFL thickness for changes that may mimic preclinical glaucomatous changes, in relation to the hormonal stress response.

Materials and Methods:
Young healthy adults (n=863) underwent a Trier Social Stress Test. Endogenous plasma adrenocorticotropic hormone (ACTH) and cortisol were measured for those who provided biological samples, and adrenal sensitivity was calculated. On the basis of cortisol levels before and after the Trier Social Stress Test, participants were categorized into one of 3 stress response types: anticipatory-responders, reactive-responders, and nonresponders. Participants underwent an eye examination that included spectral-domain optical coherence tomography to measure peripapillary RNFL thickness.

Results:
Higher levels of ACTH were associated with thinner RNFL globally (P=0.009), and at the inferotemporal (P=0.015), superotemporal (P=0.044), and temporal sectors (P=0.046). Lower adrenal sensitivity was associated with thinner RNFL inferotemporally (P<0.001) and temporally (P=0.037). However, these effect sizes were small; for example, a 10 pg/mL increase in baseline ACTH was associated with only a 3 µm thinner RNFL. RNFL thickness was not associated with plasma cortisol levels and or significantly different between groups of acute stress response patterns.

Conclusions:
Although there was a link between ACTH or adrenal sensitivity and RNFL thickness, this association was weak and its clinical significance is unclear. Despite the close associations between levels of endogenous stress markers and IOP, we found limited evidence of a link to RNFL integrity.