bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Development of Sustainable Product Design Method for Sustainable and Successful New Products
Authors: Alli H , Rashid M S S Mohd , Sulaiman R , Me R Che , Kamarudin K M 
Published: December 2019

Abstract
Currently, most of the product designers have insufficient source in integrating the potential meanings when they are developing a new product. Also, it has become extremely challenging in verifying the variables of a product that could lead towards sustainable and successful products in the market. The development of a new product is not only to cater to the users’ satisfactions, but additionally, it should attract more users. In this paper, the Sustainable Product Design Method (SPDM) is introduced as a process to identify and verify the variables of the users’ emotional responses and perceived product quality, and element of sustainability in the early stage of the design process. The SPDM is a design guideline attempt to establish the sustainable product requirements (SPR) towards the sustainable and successful products. To prove the practicability of this method, one of the successful products was chosen as a case study. It has been found that the method built is valuable in facilitating the product designers in the early stage of product design and development process. The validation signified from this process is not only contributed towards product sustainability but also increase on its success in the market.
UniSZA as the National Centre of Design for Disability in Malaysia
Authors: Ibrahim Marzuki , Ahmad Muhammad Sophist , Abdullah Imran , Omar Mohd Hisham , Ariff Ahmad Fairuz , Yusoff Sheikh Ahmad Tajuddin Sh. 
Published: December 2019

Abstract
This paper explains the initial steps of establishing the national centre of design for disabled people in Malaysia. As we all know, there is still no evidence of the existence of a creative centre for industrial product design in the country, especially for this special group. Through the initiative from the School of Industrial Design located in Universiti Sultan Zainal Abidin (UniSZA), we take a commitment to channel societal significances through designing, developing and producing innovative product design for various categories of disabilities in this country, such as physically disability, mentally disability, vision impair, learning disability, speech disability and others. It will be done entirely in a centre known as National Centre of Design for Disability (CDD), which highlights the standards and quality of design, where the outcomes meet the satisfaction of the end users through its function, ergonomics, safety, comfort and aesthetics for them to not ashamed to join their routine activities in the open public environment. The CDD improves to enhance the existing equipment alongside providing advice and assistance for the state-of-the-art research outcomes.
Preliminary analysis of hybrid laminate composite for aircraft radome application
Authors: Haris M.Y. , Fernández-López A. , Aris K. D. Mohd , Muzafar Z. , Zuhudi N.Z.M. , Laila D. , Nurhafiza K. 
Published: December 2019

Abstract
The preliminary analysis of laminate composite was conducted to analyse the optimal number of layers for aircraft radome application. In this work, the ESAComp software was used for preliminary analysis to predict the displacement during the flight operation. The ESAComp is a finite element software used for preliminary and conceptual design for composite layers. Flax fibre, glass fibre and epoxy resin were applied as the hybrid composite laminate design. The laminate construction consists of flax as the center laminate and sandwiched between glass fibre. Both fibres have the same weave pattern which is twill 2/2 and 200 gsm. The material properties for each materials were obtained from technical data sheet and used as input value for ESAComp. This software was used to analyse a single ply engineering constant by conducting fibre/matrix micromechanics analysis. The value of engineering constant of single ply for each material is then used for laminate analysis. It has range from 4,6 and 8 layers with 20%, 30% and 40% of fibre content on a flat panel with the size of 300 mm x 300 mm. The panel were fixed on each edges and under aerodynamic pressure load plus safety factor of two. Based on the result of analysis, minimum layer required is at least 6 layers if acceptance displacement is 0.1 mm. Therefore, experimental works on 6 layers hybrid laminate will be carried out to determine other requirement for aircraft radome application.
Characterization of Banana peels waste adsorbent for preliminary study of methylene blue removal from aqueous solution
Authors: Zamri M Z A , Yahya N Y , Ramli R S , Ngadi N , Widia M 
Published: December 2019

Abstract
This paper presents the removal of methylene blue (MB) from aqueous solution using adsorbent produced from Banana peels waste (BPW). Banana peels waste adsorbent (BPWA) was prepared via carbonization in laboratory muffle furnace for 1 h. A preliminary study was performed on the adsorption reaction by varying the initial concentration of MB, adsorbent dosage, contact time, pH and temperature of the aqueous solution. Under the best conditions obtained, the maximum percentage removal of MB is approximately 99 %. The potential of BPWA as dyeing wastewater adsorbent was proven by Scanning Electron Microscopy (SEM) analysis, N2 adsorption-desorption analysis and Fourier Transform Infrared Spectroscopy (FTIR). From the results, the synthesized adsorbent shown a good percentage removal of MB. In addition, the optimum conditions for the adsorption study are 1 g of adsorbent in the 1 g L−1 of MB initial concentration, for 1 h at pH 8 in 65 °C. This study reveals potential of BPW in removal of MB dyes from aqueous solution however, further studies are required to establish the applicability of the synthesized adsorbent for the treatment of wastewater from textile industry.
Fabrication and characterization of ZrW2O8-Cf/E51 negative thermal expansion composite
Authors: Ju Luyan , Zhang Jianbing , Ma Yuqin , Xia Shengyong , Wei Wenlan , Zhang Yong 
Published: December 2019

Abstract
ZrW2O8-Cf/E51 composite with a negative Coefficient of Thermal Expansion (CTE) was fabricated by a method combining mechanical stirring with ultrasonic vibration, then microstructures and properties of the composites were analyzed and summarized by scanning electron microscope (SEM), DIL 402 C thermal expansion tester and electronic universal testing machine. The results showed that particles distribution defects and impregnation defects of carbon fibers would occur when the process parameters were not controlled properly. Long curing time and good fluidity of resin were beneficial for resin impregnating carbon fibers and bubbles overflow. However, for the ZrW2O8-Cf/E51 composites studied in this paper, long curing time and low viscosity could cause particle settling and accumulation. The experimental results confirmed that the CTE (about −0.52 × 10−6/°C) and tensile strength (about 440 MPa) of E51 resin were improved with the addition of carbon fibers and ZrW2O8 particles.
Photocatalytic performance of ZnO carbon composites for the degradation of methyl orange dye
Authors: Borade Prashant A , Suroshe Jagruti S , Bogale Kashinath , Garje Shivram S , Jejurikar Suhas M 
Published: December 2019

Abstract
High yield, low cost, environmentally friendly chemical bath synthesis process is used to produce submicron structures of ZnO and ZnO-carbon composites. Synthesis of ZnO rod structures (submicron sized) were confirmed using SEM images. To synthesis ZnO-carbon composites, well characterized carbon spheres produced using aerosol assisted CVD technique was used. Use of carbon spheres as a seed during synthesis of ZnO is observed to produce multipod structures of ZnO on to the surface of carbon spheres; the growth is explained by proposing suitable model. Room temperature photoluminescence spectra recorded for ZnO and ZnO-carbon composites synthesized show a systematic disappearance of a band-edge emission (sharp peak present at ∼380 nm observed for pure ZnO) with increased number of carbon spheres. Competent photo-catalytic activity of synthesized composite is confirmed by studying photo degradation investigation performed using a model dye molecule i.e. methyl orange. The work reveals possibility to use synthesized composites as a nontoxic and biocompatible catalyst for fragmentation of a methyl orange dye molecule. Photo-degradation mechanism of a methyl orange dye is proposed herewith considering the role of carbon spheres and ZnO in presence of UV photon.
Springback comparison between DP600 and DP800 steel grades
Authors: Almeida Christyane Oliveira Leão , Lima Luís Henrique Lopes , dos Santos Pereira Marcelo 
Published: December 2019

Abstract
A comparative study of the springback effect, otherwise known as elastic return, on Dual Phase DP600 and DP800 steel sheets is reported herein, which have been widely used in the automotive industry due to having good mechanical properties, such as high strength and ductility if compared to conventional steels. For such a purpose, it is proposed to analyze whether anisotropy and varying forming parameters interfere with the springback effect or not. The parameters selected to compare DP600 with DP800 dual phase steels were descending speed of 4 mm min−1 along the vertical axis of sheets until reaching internal bending angle of 30 degrees during bending tests at two rolling angles (0 and 90 degrees), thus forming a U-shaped steel sheet. In addition to bending tests, tensile tensting and Vickers microhardness tests have been performed at three rolling angles (0, 45 and 90 degrees). It was concluded that punching rate, internal bending angle, observation time and rolling angle exert an influence on the springback effect. Thereby, there is an important contribution to areas that require quality in formability, such as vehicle structure, which must have high impact strength and energy absorption. Steel sheets with increasingly smaller thicknesses are able to reduce density, product cost and greenhouse gases emissions from automobiles.
Emergency Arbitration: Mere Innovation or Vast Improvement
Authors: Alnaber Rania 
Published: December 2019

Abstract
Effectiveness of emergency arbitration is a disputable question, which was touched by several commentators since it was first introduced in 2006. Concerns have been raised in relation to the enforceability of emergency reliefs under the New York Convention and the risk of concurrent jurisdiction between emergency arbitrators and national courts in granting interim measures prior to the constitution of the arbitral tribunal. A more specific concern is related to the suitability of introducing this mechanism, to investment arbitration. This article argues that adopting an international instrument for enforcing emergency reliefs will be the best solution. As for investment arbitration, emergency arbitrators are no less important in this type of arbitration than in commercial arbitration. However, certain features of emergency arbitration shall be tailored to meet the distinct nature of investment cases. Although certain amendments are needed to enhance the effectiveness of this relatively new mechanism, the future of emergency arbitrator is still optimistic. Therefore, to avoid any duplication of fora, courts are expected to respect emergency arbitrator's jurisdiction and only intervene when the latter is not capable of granting a relief.
PaSiT: a novel approach based on short-oligonucleotide frequencies for efficient bacterial identification and typing
Authors: Goussarov Gleb , Cleenwerck Ilse , Mysara Mohamed , Leys Natalie , Monsieurs Pieter , Tahon Guillaume , Carlier Aurélien , Vandamme Peter , Van Houdt Rob 
Published: December 2019

Abstract

Motivation
One of the most widespread methods used in taxonomy studies to distinguish between strains or taxa is the calculation of average nucleotide identity. It requires a computationally expensive alignment step and is therefore not suitable for large-scale comparisons. Short oligonucleotide-based methods do offer a faster alternative but at the expense of accuracy. Here, we aim to address this shortcoming by providing a software that implements a novel method based on short-oligonucleotide frequencies to compute inter-genomic distances.

Results
Our tetranucleotide and hexanucleotide implementations, which were optimized based on a taxonomically well-defined set of over 200 newly sequenced bacterial genomes, are as accurate as the short oligonucleotide-based method TETRA and average nucleotide identity, for identifying bacterial species and strains, respectively. Moreover, the lightweight nature of this method makes it applicable for large-scale analyses.

Availability and implementation
The method introduced here was implemented, together with other existing methods, in a dependency-free software written in C, GenDisCal, available as source code from https://github.com/LM-UGent/GenDisCal. The software supports multithreading and has been tested on Windows and Linux (CentOS). In addition, a Java-based graphical user interface that acts as a wrapper for the software is also available.

Supplementary information
Supplementary data are available at Bioinformatics online.
Improved Proofs Of Retrievability And Replication For Data Availability In Cloud Storage
Authors: Guo Wei , Qin Sujuan , Lu Jun , Gao Fei , Jin Zhengping , Wen Qiaoyan 
Published: December 2019

Abstract
For a high level of data availability and reliability, a common strategy for cloud service providers is to rely on replication, i.e. storing several replicas onto different servers. To provide cloud users with a strong guarantee that all replicas required by them are actually stored, many multi-replica integrity auditing schemes were proposed. However, most existing solutions are not resource economical since users need to create and upload replicas of their files by themselves. A multi-replica solution called Mirror is presented to overcome the problems, but we find that it is vulnerable to storage saving attack, by which a dishonest provider can considerably save storage costs compared to the costs of storing all the replicas honestly—while still can pass any challenge successfully. In addition, we also find that Mirror is easily subject to substitution attack and forgery attack, which pose new security risks for cloud users. To address the problems, we propose some simple yet effective countermeasures and an improved proofs of retrievability and replication scheme, which can resist the aforesaid attacks and maintain the advantages of Mirror, such as economical bandwidth and efficient verification. Experimental results show that our scheme exhibits comparable performance with Mirror while achieving high security.
A Decade of Varicella Screening Within a Paediatric Inflammatory Bowel Disease Population
Authors: Harris Rachel E , Curtis Lee , Hegde Vikas , Garrick Vikki , Gervais Lisa , Armstrong Lawrence , Delahunty Caroline , Eccleston Andrew , Al-Hourani Ghassan , Flynn Diana M , Merrick Victoria , Barclay Andrew R , Tayler Rachel , Hansen Richard , Russell Richard K 
Published: December 2019

AbstractIntroductionIncreased risk of opportunistic infection—e.g., varicella zoster infection—secondary to therapies is a cause of morbidity in inflammatory bowel disease [IBD] patients. The UK vaccination schedule does not include varicella immunisation. We aimed to evaluate the varicella screening and immunisation programme in a paediatric IBD population.MethodsData regarding IBD diagnosis, varicella status, and consequent immunisations/treatment interventions were collected retrospectively from the records of patients diagnosed with IBD over a 10-year period [2009–2018].ResultsIn all, 520 IBD patients were diagnosed; 505/520 [97%] had varicella testing; 46/505 [9%] were naïve. Of 501 patients, 391[78%] were tested before or within 7 days of diagnosis; this increased in the second 5-year period compared with the first (229/268 [85%] versus 162/233 [70%]; p &lt;0.00001). Median diagnosis age of naïve patients was lower [8.3 years versus 12.8 years; p &lt;0.00001]. Where vaccination was feasible, 21/31 [68%] had two and 7/31 [23%] one immunisation. Prednisolone induction led to lower rates of vaccination (5/13 [39%] versus 23/33 [70%] for other induction therapies; p =0.02). Of 28 vaccinated patients, 5 [18%] had suspected breakthrough varicella; and 6/18 [33%] unimmunised patients required post-exposure prophylaxis or treatment for varicella. Immunisation was associated with a decrease in patients requiring post-exposure prophylaxis (0/28 [0%] versus 5/18 [28%]; p =0.0006) and varicella-related hospital admission (1/28 [4%] versus 4/18 [22%]; p =0.01).ConclusionsHigh rates of varicella screening and immunisation within a PIBD population are possible, resulting in a reduction in hospital admissions for varicella treatment. Varicella immunisation may be of increasing importance within the PIBD population with the emergence of novel therapeutic strategies.
Deep structure of the Hellenic lithosphere from teleseismic Rayleigh-wave tomography
Authors: Kassaras I , Kapetanidis V , Karakonstantis A , Papadimitriou P 
Published: December 2019

SUMMARYThis research provides new constraints on the intermediate depth upper-mantle structure of the Hellenic lithosphere using a three-step Rayleigh-wave tomography. Broadband waveforms of about 1000 teleseismic events, recorded by ∼200 permanent broad-band stations between 2010 and 2018 were acquired and processed. Through a multichannel cross-correlation technique, the fundamental mode Rayleigh-wave phase-velocity dispersion curves in the period range 30–90 s were derived. The phase-velocities were inverted and a 3-D shear velocity model was obtained down to the depth of 140 km. The applied method has provided 3-D constraints on large-scale characteristics of the lithosphere and the upper mantle of the Hellenic region. Highlighted resolved features include the continental and oceanic subducting slabs in the region, the result of convergence between Adria and Africa plates with the Aegean. The boundary between the oceanic and continental subduction is suggested to exist along a trench-perpendicular line that connects NW Peloponnese with N. Euboea, bridging the Hellenic Trench with the North Aegean Trough. No clear evidence for trench-perpendicular vertical slab tearing was resolved along the western part of Hellenic Subduction Zone; however, subcrustal seismicity observed along the inferred continental–oceanic subduction boundary indicates that such an implication should not be excluded. The 3-D shear velocity model supports an N–S vertical slab tear beneath SW Anatolia that justifies deepening, increase of dip and change of dip direction of the Wadati-Benioff Zone. Low velocities found at depths &lt;50 km beneath the island and the backarc, interrelated with recent/remnant volcanism in the Aegean and W. Anatolia, are explained by convection from a shallow asthenosphere.
Genetic Factors, Adherence to Healthy Lifestyle Behavior, and Risk of Invasive Breast Cancer Among Women in the UK Biobank
Authors: Arthur Rhonda S , Wang Tao , Xue Xiaonan , Kamensky Victor , Rohan Thomas E 
Published: December 2019

Abstract

Background
Breast cancer is considered to result from a combination of genetic and lifestyle-related factors, but the degree to which an overall healthy lifestyle may attenuate the impact of multiple genetic variants on invasive breast cancer risk remains equivocal.

Methods
Using Cox proportional hazards regression models, we examined the association of a modified healthy lifestyle index (HLI) with risk of invasive breast cancer by genetic risk group among 146 326 women from the UK Biobank. We generated an HLI score based on a combination of diet, physical activity, smoking, alcohol consumption and anthropometry, and a polygenic risk score (PRS) using 304 breast cancer-associated genetic loci.

Results
Among premenopausal and postmenopausal women, a favorable lifestyle (highest tertile) was associated with 22% and 31% reductions in invasive breast cancer risk, respectively (hazard ratio [HR]high vs low = 0.78, 95% confidence interval [CI] = 0.64 to 0.94; HRhigh vs low = 0.69, 95% CI = 0.63 to 0.77, respectively), whereas a high PRS (highest tertile) was associated with more than a doubling in the risk in both groups. For premenopausal women, the greatest risk reduction in association with the HLI was seen among those with a high PRS (HRhigh vs low = 0.73, 95% CI = 0.75 to 0.95). In postmenopausal women, those with a favorable lifestyle had 30%, 29%, and 32% reductions in risk of invasive breast cancer in the low, intermediate, and high PRS groups, respectively (HRhigh vs low = 0.70, 95% CI = 0.56 to 0.88; HRhigh vs low = 0.71, 95% CI = 0.59 to 0.84; and HRhigh vs low = 0.68, 95% CI = 0.59 to 0.78, respectively). There was an additive but not multiplicative interaction between the HLI score and PRS for postmenopausal and, to a lesser extent, premenopausal women.

Conclusion
Our findings support the view that an overall healthy lifestyle may attenuate the impact of genetic factors on invasive breast cancer risk among women of European ancestry.
Intranasal Methylprednisolone Effectively Reduces Neuroinflammation in Mice With Experimental Autoimmune Encephalitis
Authors: Rassy Dunia , Bárcena Brandon , Pérez-Osorio Iván Nicolás , Espinosa Alejandro , Peón Alberto N , Terrazas Luis I , Meneses Gabriela , Besedovsky Hugo O , Fragoso Gladis , Sciutto Edda 
Published: December 2019

Abstract
Relapsing-remitting multiple sclerosis, the most common form, is characterized by acute neuroinflammatory episodes. In addition to continuous disease-modifying therapy, these relapses require treatment to prevent lesion accumulation and progression of disability. Intravenous methylprednisolone (1–2 g for 3–5 days) is the standard treatment for relapses. However, this treatment is invasive, requires hospitalization, leads to substantial systemic exposure of glucocorticoids, and can only reach modest concentrations in the central nervous system (CNS). Intranasal delivery may represent an alternative to deliver relapse treatment directly to the CNS with higher concentrations and reducing side effects. Histopathological analysis revealed that intranasal administration of methylprednisolone to mice with experimental autoimmune encephalomyelitis (EAE) suppressed the neuroinflammatory peak, and reduced immune cell infiltration and demyelination in the CNS similarly to intravenous administration. Treatment also downregulated Iba1 and GFAP expression. A similar significant reduction of IL-1β, IL-6, IL-17, IFN-γ, and TNF-α levels in the spinal cord was attained in both intranasal and intravenously treated mice. No damage in the nasal cavity was found after intranasal administration. This study demonstrates that intranasal delivery of methylprednisolone is as efficient as the intravenous route to treat neuroinflammation in EAE.