bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural Stem Cell Extracellular Vesicles Disrupt Midline Shift Predictive Outcomes in Porcine Ischemic Stroke Model
Authors: Spellicy Samantha E. , Kaiser Erin E. , Bowler Michael M. , Jurgielewicz Brian J. , Webb Robin L. , West Franklin D. , Stice Steven L. 
Published: December 2019

AbstractMagnetic resonance imaging (MRI) is a clinically relevant non-invasive imaging tool commonly utilized to assess stroke progression in real time. This study investigated the utility of MRI as a predictive measure of clinical and functional outcomes when a stroke intervention is withheld or provided, in order to identify biomarkers for stroke functional outcome under these conditions. Fifteen MRI and ninety functional parameters were measured in a middle cerebral artery occlusion (MCAO) porcine ischemic stroke model. Multiparametric analysis of correlations between MRI measurements and functional outcome was conducted. Acute axial and coronal midline shift (MLS) at 24 h post-stroke were associated with decreased survival and recovery measured by modified Rankin scale (mRS) and were significantly correlated with 52 measured acute (day 1 post) and chronic (day 84 post) gait and behavior impairments in non-treated stroked animals. These results suggest that MLS may be an important non-invasive biomarker that can be used to predict patient outcomes and prognosis as well as guide therapeutic intervention and rehabilitation in non-treated animals and potentially human patients that do not receive interventional treatments. Neural stem cell–derived extracellular vesicle (NSC EV) was a disruptive therapy because NSC EV administration post-stroke disrupted MLS correlations observed in non-treated stroked animals. MLS was not associated with survival and functional outcomes in NSC EV–treated animals. In contrast to untreated animals, NSC EVs improved stroked animal outcomes regardless of MLS severity.
State Uncertainty Normality Detection
Authors: Flegel Sven K. , Bennett James C. 
Published: December 2019

AbstractTwo fundamentally different approaches of determining normality of the probability density function of the state estimation error are compared by application to a range of test cases. The first method is the Henze-Zirkler test, which operates on a random particle sample. The variability of its result is quantified. Using this method, departure from normality has been found to occur in three stages which are detailed. The second test compares the offset in whitened space of the predicted state to the predicted covariance mean obtained from the unscented transform. This test is much more efficient than the random particle based approach and can be applied using any perturbations model. The comparison is performed on the state estimation error in Cartesian space and using two-body motion without process noise. The more efficient, unscented transform based approach shows excellent agreement with the Henze-Zirkler test for constructed test cases. Application to orbit determination results from passive optical observations assessed with a Batch-Least-Squares orbit determination however reveals some discrepancies which have yet to be understood and underline the importance of rigorous testing.
Epigenetics of aging and disease: a brief overview
Authors: Pagiatakis Christina , Musolino Elettra , Gornati Rosalba , Bernardini Giovanni , Papait Roberto 
Published: December 2019

AbstractAging is an important risk factor for several human diseases such as cancer, cardiovascular disease and neurodegenerative disorders, resulting from a combination of genetic and environmental factors (e.g., diet, smoking, obesity and stress), which, at molecular level, cause changes in gene expression underlying the decline of physiological function. Epigenetics, which include mechanisms regulating gene expression independently of changes to DNA sequence, regulate gene expression by modulating the structure of chromatin or by regulating the binding of transcriptional machinery to DNA. Several studies showed that an impairment of epigenetic mechanisms promotes alteration of gene expression underlying several aging-related diseases. Alteration of these mechanisms is also linked with changes of gene expression that occurs during aging processes of different tissues. In this review, we will outline the potential role of epigenetics in the onset of two age-related pathologies, cancer and cardiovascular diseases.
Zwei Arten von Selbstbindungen
Authors: Hallich Oliver 
Published: December 2019

ZusammenfassungUnter „Selbstbindungen“ versteht man in medizinethischen Kontexten vorwegnehmende Bitten von Patienten an ihre Ärzte, eigene spätere Behandlungspräferenzen nicht zu befolgen. In diesem Beitrag werden zwei Arten von Selbstbindungen voneinander unterschieden. Wird nach einer Phase des Kompetenzverlustes, für die ein Handeln gegen den Patientenwillen vorausschauend autorisiert wird, die Kompetenz wiedererlangt, handelt es sich um eine Odysseus-Anweisung. Wird aber, wie insbesondere im Falle von Anweisungen für das Spätstadium der Demenz, die Kompetenz nach der Behandlungssituation nicht wiedererlangt, liegt eine Selbstbindung vor, die jedoch keine Odysseus-Anweisung ist. In Bezug auf die erste Art von Selbstbindungen kommt die erwartete spätere Zustimmung des Patienten als Rechtfertigungskriterium für ein Handeln gegen den Patienwillen in Betracht. In Bezug auf die zweite Art von Selbstbindungen ist hingegen zu fragen, ob der Wille des Patienten in der Behandlungssituation als Widerruf des früheren Willens der kompetenten Person gelten kann. Ist dies der Fall, ist der zum früheren Zeitpunkt geäußerte Wunsch nicht mehr als derjenige einschlägig, der festlegt, was der Patient in der Behandlungssituation will.
Forms of Bullying and Associations Between School Perceptions and Being Bullied Among Finnish Secondary School Students Aged 13 and 15
Authors: Markkanen Ilona , Välimaa Raili , Kannas Lasse 
Published: December 2019

AbstractThe study aimed to examine the extent to which Finnish secondary school students experience bullying, how they are bullied, and whether being bullied is associated with school perceptions. The analyses were based on data from the Finnish part of the internationalHealth Behaviour in School-aged Children(HBSC) study, and were obtained from 4262 students aged 13 and 15. The sample was nationally representative. Logistic regression analysis was performed to identify the associations between school perceptions and being bullied. Younger students reported being bullied more often than older students. Among younger students, boys were more often bullied than girls of the same age. There was no significant difference between the genders among the older students. The most common form of being bullied was verbal teasing. Boys tended to be bullied in physical ways, while girls were bullied in more indirect ways. Students with low levels of school engagement, students with poor relations with peers, and students who reported better teacher-student relations were more likely to be bullied. Feelings of loneliness and lower family affluence were also associated with being bullied. Improving the perceptions of school, and of the school experience as a whole, might have an effect on bullying at school.
The contribution of school safety to weight‐related health behaviors for transgender youth
Authors: Pistella Jessica , Ioverno Salvatore , Rodgers Melissa A. , Russell Stephen T. 
Published: December 2019

ABSTRACTIntroductionThe aim of the present study is to examine gender identity disparities in different kinds of weight‐related health behaviors, including physical activity, participation in physical education at school, and healthy and unhealthy eating habits, and to investigate the relationship between school safety and such behaviors in a sample of transgender and non‐transgender students.MethodWe analyzed a statewide sample of 31,609 students (Mage = 14.04, SD = 1.70; 1.1% transgender). We used multilevel regression models to examine the interactive effects of gender identity and perceptions of school safety on the 4 different outcome variables (physical activity, physical education, healthy and unhealthy eating habits). All models included student‐ and school‐level characteristics as controls.ResultsFindings indicated that transgender students, when compared to non‐transgender students, reported (a) feeling less safe at school; (b) more physical activity, but less participation in physical education at school; and (c) both more healthy as well as unhealthy eating behaviors. Adjusted regression models showed a significant interaction between gender identity and perceived school safety on healthy eating behaviors; simple slopes indicated that transgender students have healthier eating behaviors when the school context is perceived as safe compared to those who perceived the school as less safe.ConclusionsSchool interventions are needed to improve school safety for transgender youth and to reduce gender identity‐related disparities in healthy eating and physical activity. Research implications and limitations are discussed.
INTERNATIONAL HUMANITARIAN LAW AND COUNTER-TERRORISM: FUNDAMENTAL VALUES, CONFLICTING OBLIGATIONS
Authors: McKeever David 
Published: December 2019

AbstractThe interaction of international counter-terrorism laws with IHL is an area of renewed focus, amid widespread concern that the former are being (mis)applied to criminalise the provision of humanitarian assistance envisaged under the latter. The Security Council has begun to consider this issue in resolutions adopted in March and July 2019, but difficult questions of law and fact remain. These questions have significant practical consequences—for humanitarian agencies and those they seek to assist, as well as for States that must weigh different, and possibly conflicting, legal obligations. Much of the analysis to date and the solutions proposed, pay insufficient attention to the specifics of each legal regime.
The Condemnation-Absolution Syndrome: Issues of Validity and Generality
Authors: Keohane Robert O. 
Published: December 2019

AbstractIn their article “Just War and Unjust Soldiers: American Public Opinion on the Moral Equality of Combatants,” Scott Sagan and Benjamin Valentino argue that the American public evaluates soldiers’ wartime actions more according to whether the war they are fighting was initiated justly, than on their actions during warfare. In this respect, their views are more similar to those of revisionist philosophers than to those of traditional just war theorists. Before leaping to broad conclusions from their survey, it should be replicated. If the findings hold in the replication, intriguing questions could be asked about comparative cross-national attitudes and about the relationship between democracy and war.
On Reciprocity and Practical Morality: A Response to Sagan and Valentino
Authors: Walzer Michael 
Published: December 2019

AbstractThe findings reported in the article “Just War and Unjust Soldiers: American Public Opinion on the Moral Equality of Combatants,” by Scott Sagan and Benjamin Valentino, are indeed disturbing, but I am not convinced that they tell us all we need to know about public attitudes. Different questions, those that invite respondents to reflect on the reciprocal nature of practical morality (exemplified by the golden rule: “Do unto others . . .”), might reveal very different views of justified and unjustified conduct in war. I believe that these views, regarding, for example, the treatment of prisoners of war, would probably support the idea of the moral equality of soldiers on the battlefield.
Minimax functions on Galton–Watson trees
Authors: Martin James B. , Stasiński Roman 
Published: December 2019

AbstractWe consider the behaviour of minimax recursions defined on random trees. Such recursions give the value of a general class of two-player combinatorial games. We examine in particular the case where the tree is given by a Galton–Watson branching process, truncated at some depth 2n, and the terminal values of the level 2n nodes are drawn independently from some common distribution. The case of a regular tree was previously considered by Pearl, who showed that as n → ∞ the value of the game converges to a constant, and by Ali Khan, Devroye and Neininger, who obtained a distributional limit under a suitable rescaling.For a general offspring distribution, there is a surprisingly rich variety of behaviour: the (unrescaled) value of the game may converge to a constant, or to a discrete limit with several atoms, or to a continuous distribution. We also give distributional limits under suitable rescalings in various cases.We also address questions of endogeny. Suppose the game is played on a tree with many levels, so that the terminal values are far from the root. To be confident of playing a good first move, do we need to see the whole tree and its terminal values, or can we play close to optimally by inspecting just the first few levels of the tree? The answers again depend in an interesting way on the offspring distribution.We also mention several open questions.
Temporal Trends and Future Predictions of Regional EMS System Utilization Using Statistical Modeling
Authors: Carr Michael J. , Bauter Robert , Shepherd Philip , Robbins Vincent , McKechnie A.J. , Cappuccia Beatrice , Merlin Mark A. 
Published: December 2019

AbstractIntroduction:Trends in utilization of Emergency Medical Services (EMS) systems can be used to extrapolate future use of an EMS system, which will be valuable for the budgeting and planning of finances and resources. The best model for incorporation of seasonal and regional fluctuations in utilization to predict future utilization is unknown.Problem:Authors aimed to trend patterns of utilization in a regional EMS system to identify the needs of a growing population and to allow for a better understanding of how the EMS system is used on a basis of call volume and frequency of EMS transportation. The authors then used a best-fitting prediction model approach to show how the studied EMS system will be used in future years.Methods:Systems data were retrospectively extracted by using the electronic medical records of the studied EMS system and its computer-assisted dispatch (CAD) database from 2010 through 2017. All EMS dispatches entering the system’s 9-1-1 public service access point were captured. Annual utilization data were available from 2010 through 2017, while quarterly data were available only from 2013 through 2017. The 9-1-1 utilization per capita, Advanced Life Support (ALS) utilization per capita, and ALS cancel rates were calculated and trended over the study period. The methods of prediction were assessed through a best-fitting model approach, which statistically suggested that Additive Winter’s approach (SAS) was the best fit to determine future utilization and ALS cancel rates.Results:Total 9-1-1 call volume per capita increased by 32.46% between 2010 and 2017, with an average quarterly increase of 0.78% between 2013 and 2017. Total ALS call volume per capita increased by 1.93% between 2010 and 2017. Percent ALS cancellations (cancelled en route to scene) increased by eight percent between 2010 and 2017, with an average quarterly increase of 0.42% (2013–2017). Predictions to end of 2019 using Additive Winter’s approach demonstrated increasing trends in 9-1-1 call volume per capita (R2 = 0.47), increasing trends of ALS utilization per capita (R2 = 0.71), and increasing percent ALS cancellation (R2 = 0.93). Each prediction showed increasing future trends with a 95% confidence interval.Conclusions:The authors demonstrate paramount per capita increases of 9-1-1 call volume in the studied ALS system. There are concomitant increases of ALS cancellations prior to arrival, which suggests a potential burden on this regional ALS response system.
Rationale for Military Involvement in Humanitarian Assistance and Disaster Relief
Authors: Canyon Deon V. , Ryan Benjamin J. , Burkle Frederick M. 
Published: December 2019

AbstractGood relations and trust are the foundation of soft power diplomacy and are essential for the accomplishment of domestic interventions and any bilateral or multilateral endeavor. Military use for assistance and relief is not a novel concept, but it has increased since the early 1990s with many governments choosing to provide greater numbers of forces and assets to assist domestically and internationally. The increase is due to the growing lack of capacity in global humanitarian networks and increasingly inadequate resources available to undertake United Nations humanitarian assistance and disaster relief (HADR) missions. In response, the military has been more proactive in pursuing the improvement of military-to-military and military-to-civilian integration. This trend reflects a move towards more advanced and comprehensive approaches to security cooperation and requires increased support from the civilian humanitarian sector to help meet the needs of the most vulnerable. Military assistance is progressing beyond traditional methods to place a higher value on issues relating to civil cooperation, restoring public health infrastructure, protection, and human rights, all of which are ensuring a permanent diplomatic role for this soft power approach.
Dark carbon fixation in the Arabian Sea oxygen minimum zone contributes to sedimentary organic carbon (SOM)
Authors: Lengger Sabine K. , Rush Darci , Mayser Jan Peter , Blewett Jerome , Schwartz‐Narbonne Rachel , Talbot Helen M. , Middelburg Jack J. , Jetten Mike S.M. , Schouten Stefan , Sinninghe Damsté Jaap S. , Pancost Richard D. 
Published: December 2019

AbstractIn response to rising CO2 concentrations and increasing global sea surface temperatures, oxygen minimum zones (OMZ), or “dead zones”, are expected to expand. OMZs are fueled by high primary productivity, resulting in enhanced biological oxygen demand at depth, subsequent oxygen depletion, and attenuation of remineralization. This results in the deposition of organic carbon‐rich sediments. Carbon drawdown is estimated by biogeochemical models; however, a major process is ignored: carbon fixation in the mid‐ and lower water column. Here, we show that chemoautotrophic carbon fixation is important in the Arabian Sea OMZ; and manifests in a 13C‐depleted signature of sedimentary organic carbon. We determined the δ13C values of Corg deposited in close spatial proximity but over a steep bottom‐water oxygen gradient, and the δ13C composition of biomarkers of chemoautotrophic bacteria capable of anaerobic ammonia oxidation (anammox). Isotope mixing models show that detritus from anammox bacteria or other chemoautotrophs likely forms a substantial part of the organic matter deposited within the Arabian Sea OMZ (~17%), implying that the contribution of chemoautotrophs to settling organic matter is exported to the sediment. This has implications for the evaluation of past, and future, OMZs: biogeochemical models that operate on the assumption that all sinking organic matter is photosynthetically derived, without new addition of carbon, could significantly underestimate the extent of remineralization. Oxygen demand in oxygen minimum zones could thus be higher than projections suggest, leading to a more intense expansion of OMZs than expected.
MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models
Authors: Du Yehong , Du Yexiang , Zhang Yun , Huang Zhilin , Fu Min , Li Junjie , Pang Yayan , Lei Peng , Wang Yu Tian , Song Weihong , He Guiqiong , Dong Zhifang 
Published: December 2019

AbstractMitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues. Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease (AD). However, the role of MKP-1 in AD pathogenesis remains elusive. Here, we report that MKP-1 levels were decreased in the brain tissues of patients with AD and an AD mouse model. The reduction in MKP-1 gene expression appeared to be a result of transcriptional inhibition via transcription factor specificity protein 1 (Sp1) cis-acting binding elements in the MKP-1 gene promoter. Amyloid-β (Aβ)-induced Sp1 activation decreased MKP-1 expression. However, upregulation of MKP-1 inhibited the expression of both Aβ precursor protein (APP) and β-site APP-cleaving enzyme 1 by inactivating the extracellular signal-regulated kinase 1/2 (ERK)/MAPK signaling pathway. Furthermore, upregulation of MKP-1 reduced Aβ production and plaque formation and improved hippocampal long-term potentiation (LTP) and cognitive deficits in APP/PS1 transgenic mice. Our results demonstrate that MKP-1 impairment facilitates the pathogenesis of AD, whereas upregulation of MKP-1 plays a neuroprotective role to reduce Alzheimer-related phenotypes. Thus, this study suggests that MKP-1 is a novel molecule for AD treatment.
DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy
Authors: Zhou Hao , Zhu Pingjun , Wang Jin , Toan Sam , Ren Jun 
Published: December 2019

AbstractDNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel housekeeper of hepatic mitochondrial homeostasis outside the DNA repair process. In this study, DNA-PKcs was upregulated in the livers of mice that were exposed to alcohol; the expression of DNA-PKcs positively correlated with hepatic steatosis, fibrosis, apoptosis, and mitochondrial damage. Functional studies revealed that liver-specific DNA-PKcs knockout (DNA-PKcsLKO) mice were protected from chronic ethanol-induced liver injury and mitochondrial damage. Mechanistic investigations established that DNA-PKcs promoted p53 activation, which elevated dynamin-related protein 1 (Drp1)-related mitochondrial fission but repressed FUN14 domain containing 1 (FUNDC1)-required mitophagy. Excessive fission and defective mitophagy triggered mtDNA damage, mitochondrial respiratory inhibition, mROS overproduction, cardiolipin oxidation, redox imbalance, calcium overload, and hepatic mitochondrial apoptosis. In contrast, the deletion of DNA-PKcs rescued these phenotypic alterations, which alleviated the susceptibility of hepatocytes to alcohol-induced cytotoxicity. Additionally, we also showed that orphan nuclear receptor subfamily 4 group A member 1 (NR4A1) was the upstream signal for DNA-PKcs activation and that the genetic ablation of NR4A1 ameliorated the progression of alcohol-related liver disease (ARLD); these results were similar to those obtained in DNA-PKcs knockout mice. Collectively, our results identified the NR4A1/DNA-PKcs/p53 axis as a novel signaling pathway responsible for ARLD pathogenesis that acts by activating Drp1-related mitochondrial fission and restricting FUNDC1-required mitophagy. The findings have potential implications for new approaches for ARLD therapy.