bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain imaging measurements of fibrillar amyloid‐β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele
Authors: Ghisays Valentina , Goradia Dhruman D. , Protas Hillary , Bauer Robert J. , Devadas Vivek , Tariot Pierre N. , Lowe Val J. , Knopman David S. , Petersen Ronald C. , Jack Clifford R. , Caselli Richard J. , Su Yi , Chen Kewei , Reiman Eric M. 
Published: December 2019

AbstractIntroductionWe previously characterized associations between brain imaging measurements of amyloid‐β (Aβ) plaque burden and apolipoprotein E (APOE) ε4 gene dose in a small number of cognitively unimpaired late‐middle‐aged APOE ε4 homozygotes (HMs), heterozygotes (HTs), and noncarriers (NCs). We now characterize cross‐sectional Aβ plaque, tau tangle, and cortical atrophy (neurodegeneration) measurements, classifications, and associations with age in a larger number of unimpaired HMs, HTs, and NCs over a wider age range.MethodsWe analyzed 11C Pittsburgh compound B (Aβ) positron emission tomography (PET), flortaucipir (tau) PET, and volumetric magnetic resonance imaging data from 164 study participants of age 47–86 years, including 26 APOE ε4 HMs, 48 HTs, and 90 NCs matched for age and sex.ResultsAβ PET measurements rose, plateaued at the respective ages of 68 and 76, and then declined with age in unimpaired HM and HT groups. Compared with NCs, these two groups began to have significantly higher Aβ PET measurements at ages 62 and 70, respectively, and no longer had significantly higher measurements by ages 71 and 78, respectively. They began to have significantly higher entorhinal cortex tau PET measurements at ages 66 and 70, respectively, and no longer had significantly higher measurements by ages 74 and 78, respectively. Brain atrophy measurements tended to decline slowly with age in all three genetic groups. Their elevated tau PET measurements were attributable to those with positive Aβ PET scans. 41.0%, 18.0%, and 5.0% of the 47‐ to 70‐year‐old HMs, HTs, and NCs and 25.0%, 79.0%, and 38.0% of the 71‐ to 86‐year‐old HMs, HTs, and NCs had positive Aβ PET scans, and the long‐term recall memory scores are significantly higher in the older HMs than in HT and NC groups, suggesting resistance to Aβ deposition in those HMs who remained unimpaired at older ages.ConclusionsThis study provides information about Aβ plaque burden, tau tangle burden, and neurodegeneration in cognitively unimpaired persons at three levels of genetic risk for AD. Unimpaired APOE ε4 HMs can be studied before their 70s to evaluate the understanding of factors, processes, and interventions involved in the predisposition to and prevention of AD, and after their 70s, to discover factors, processes, and interventions involved in the resilience or resistance to and prevention of AD.
The fluctuation of APC gene in WNT signaling with adenine deletion of adenomatous polyposis coli, is associated in colorectal cancer
Authors: Norollahi Seyedeh Elham , Hamidian Seyed Mohammad Taghi , Kohpar Zeynab Khazaee , Azadi Rezvan , Rostami Pooya , Vahidi Sogand , Ghazanfari Sahar , Shabe Farnaz Azar , Khaksar Roya , Samadani Ali Akbar 
Published: December 2019

AbstractColorectal cancer is one of the most important malignancies in the classification of gastrointestinal cancers. One of the predisposing factors at molecular level for this cancer is via WNT signaling which is associated with the vast numbers of different genes. Thus, in this study, we aimed to investigate whether Adenomatous Polyposis Coli gene (APC) mutation of rs41115in two locations such as 132.002 and 131.989 acts as a trigger or cause of colorectal cancer. Relatively, 30 blood samples of colorectal cancer patients and 30 normal blood samples as control group after colonoscopy and also confirmation of pathology report at Rohani Hospital in Babol (Iran) were investigated. The primers were designed in order to be included the rs41115 to identify the particular polymorphisms of gene. The polymerase chain reaction (PCR direct sequencing method) was used. Conclusively, deletion of adenine in two specific locations such as 131.989 and 132.002 has been identified, but there was no relationship between rs41115 polymorphisms located in adenomatous polyposis coli gene and colorectal cancer.
Primary extraperitoneal rectum lymphoma in AIDS patient
Authors: Garcia Ana Maria Stapasolla Vargas , Sangali Marlei , Filho Antoninho Jose Tonatto , Lara Caroline , Silva Cibele Corbellini Rosa da , Saturnino Marcos Paulo Barreto , Carvalho Luciano Pinto de 
Published: December 2019

Abstract
Introduction The gastrointestinal lymphoma can be classified in primary or secondary, and this is important regarding diagnosis and subsequent treatment. Primary gastrointestinal lymphoma of the rectum is rare and therefore lacks data in medical literature. Its incidence has been increasing and that fact may be related to a higher incidence in immunosuppressive therapy and immunosuppressive diseases (such as AIDS).
Metodology 19 articles have been reviewed, searched online on the Scielo and PubMed databases. The goal was to increase data available regarding this pathology and improve its therapy.
Discussion Primary GI lymphoma of the rectum presents as hematochezia, rectal pain, change in bowel habits. PET/CT is the first choice exam to pursue investigation; however abdominal CT and MRI reveal sufficient information and are much more available in daily practice. Plasmablastyc lymphoma is an aggressive subtype and is usually associated with AIDS patients. There are no available treatment protocols for this specific type of lymphoma and colonic lymphoma's therapy is usually used for this patient (such as ECHOP and CHOP).
Conclusion As rare as this pathology is, this article aims to improve the available data and provide useful information regarding diagnosis and therapy.
Evan Mawarire’s #ThisFlag as Tactical Lyric: The Role of Digital Speech in Imagining a Networked Zimbabwean Nation
Authors: Sacks Susanna L. 
Published: December 2019

Abstract:Evan Mawarire’s poetic video “This Flag,” first posted on Facebook on April 20, 2016, mobilized an international protest movement against then-president of Zimbabwe Robert Mugabe between April and September of 2016. In the video, Mawarire built on the poetics of anti-colonial resistance and nationalization to create a rallying cry. The piece’s remediation through the hashtag channel #ThisFlag created rhetorical links between digital organizing and grounded action. This literary perspective on contemporary discussions of social media and collective identity formation shows how the poetic elements of the video enabled Mawarire’s claim to spread and motivate a grounded movement.
Archives, the Digital Turn, and Governance in Africa
Authors: Chamelot Fabienne , Hiribarren Vincent , Rodet Marie 
Published: December 2019

Abstract:With the rise of information technology, an increasing proportion of public African archives are being digitized and made accessible on the internet. The same is being done to a certain extent with private archives too. As much as the new technologies are raising enthusiasm, they have prompted discussion among researchers and archivists, on subjects ranging from matters of intellectual property to sovereignty and governance. Digital archiving disrupts archival norms and practices, opening up a field of reflection relatively little explored by historians. This article therefore seeks to reflect on the digital turn of African archives as a subject for study in its own right, located at the crossroads of political and economic interests.
New kingenoid (Terebratellidina) brachiopods with larger body sizes from the Early Cretaceous of Zengővárkony (Mecsek Mountains, Hungary)
Authors: Bujtor László , Vörös Attila 
Published: December 2019

AbstractThe small, Lower Cretaceous, iron ore deposit at Zengővárkony (Mecsek Mountains, southern Hungary, Europe) contains new brachiopod taxa of kingenoid relationships.Dictyothyropsis vogli,Zittelina hofmanni, andSmirnovina ferrariaare described as new species from late Valanginian to earliest Hauterivian strata. The new taxa strengthen the presence of Early Cretaceous biogeographical connections with the Western Carpathians and the Pieniny Klippen Belt of southern Poland. The newly described taxa have significantly larger dimensions than their closest relatives from the type localities, which is in line with previous research on brachiopods from this environment. These brachiopods lived in a nutrient-rich, unique environment related to iron-ore deposition linked to former hydrothermal activity on the seafloor that might have contributed to the large size of these brachiopods. Larger than normal rhynchonellide and terebratulidine brachiopods have previously been recorded from this locality.UUID:http://zoobank.org/353882-2838-4eb7-b21a-8cc665d13408
PREDICATIVE COLLAPSING PRINCIPLES
Authors: FREUND ANTON 
Published: December 2019

AbstractWe show that arithmetical transfinite recursion is equivalent to a suitable formalization of the following: For every ordinal α there exists an ordinal β such that $1 + \beta \cdot \left( {\beta + \alpha } \right)$ (ordinal arithmetic) admits an almost order preserving collapse into β. Arithmetical comprehension is equivalent to a statement of the same form, with $\beta \cdot \alpha$ at the place of $\beta \cdot \left( {\beta + \alpha } \right)$. We will also characterize the principles that any set is contained in a countable coded ω-model of arithmetical transfinite recursion and arithmetical comprehension, respectively.
Estimating signaling games in international relations: problems and solutions
Authors: Crisman-Cox Casey , Gibilisco Michael 
Published: December 2019

AbstractSignaling games are central to political science but often have multiple equilibria, leading to no definitive prediction. We demonstrate that these indeterminacies create substantial problems when fitting theory to data: they lead to ill-defined and discontinuous likelihoods even if the game generating the data has a unique equilibrium. In our experiments, currently used techniques frequently fail to uncover the parameters of the canonical crisis-signaling game, regardless of sample size and number of equilibria in the data generating process. We propose three estimators that remedy these problems, outperforming current best practices. We fit the signaling model to data on economic sanctions. Our solutions find a novel U-shaped relationship between audience costs and the propensity for leaders to threaten sanctions, which current best practices fail to uncover.
Increased consumption of calcium from fat-free milk, energy-restricted diet and educational activities improves metabolic control in overweight type 2 diabetic patients
Authors: Costa Jorge de Assis , Gomes Júnia Maria Geraldo , Ribeiro Priscila Vaz de Melo , Alfenas Rita de Cássia Gonçalves 
Published: December 2019

AbstractWe assessed the effects of increased Ca consumption from fat-free milk in an energy-restricted diet and educational activities in the metabolic control of overweight type 2 diabetes mellitus (T2DM) patients. Fourteen subjects with T2DM (BMI 29·4 (sd 4·5) kg/m2, low habitual Ca consumption (<600 mg/d)) were included in this randomised, crossover clinical trial. Subjects were randomly allocated to one of the two interventions: drink containing 700 mg of Ca (DAIR) or drink containing 0 mg of Ca (CONT) for ninety consecutive days each. Energy-restricted diets (–500 kcal/d; –2092 kJ/d), containing 800 mg of Ca from dietary sources/d, were prescribed for both groups. Questionnaires were applied at baseline and at the end of the study to assess the subjects’ knowledge on the disease and on self-care, biochemical variables and physical activity. Blood pressure, food intake, body composition and anthropometry were assessed at baseline, days 45 and 90. There was a higher reduction of body fat %, waist circumference, hip circumference, neck circumference, waist:hip ratio, sagittal abdominal diameter, diastolic/systolic blood pressure and an increase in fat-free mass % in DAIR than in CONT. Uric acid, fasting glucose, Hb1Ac, parathyroid hormone and alanine aminotransferase concentrations reduced and vitamin D concentration increased after 90 d in DAIR compared with CONT. The consumption of energy-restricted diet containing 1200 mg Ca/d seems to favour metabolic control in subjects with T2DM. The educational activities increased the knowledge on the disease care.
Multi-scale assessment of winter wheat yield gaps with an integrated evaluation framework in the Huang-Huai-Hai farming region in China
Authors: Li S. , Liu J. , Shang M. , Jia H. , Feng Y. , Chu Q. , Chen F. 
Published: December 2019

AbstractQuantifying reasonable crop yield gaps and determining potential regions for yield improvement can facilitate regional plant structure adjustment and promote crop production. The current study attempted to evaluate the yield gap in a region at multi-scales through model simulation and farmer investigation. Taking the winter wheat yield gap in the Huang-Huai-Hai farming region (HFR) for the case study, 241 farmers’ fields in four typical high-yield demonstration areas were surveyed to determine the yield limitation index and attainable yield. In addition, the theoretical and realizable yield gap of winter wheat in 386 counties of the HFR was assessed. Results showed that the average field yield of the demonstration plots was 8282 kg/ha, accounting for 0.72 of the potential yield, which represented the highest production in the region. The HFR consists of seven sub-regions designated 2.1–2.7: the largest attainable yield gap existed in the 2.6 sub-region, in the southwest of the HFR, while the smallest was in the 2.2 sub-region, in the northwest of the HFR. With a high irrigated area rate, the yield gap in the 2.2 sub-region could hardly be reduced by increasing irrigation, while a lack of irrigation remained an important limiting factor for narrowing the yield gap in 2.3 sub-region, in the middle of the HFR. Therefore, a multi-scale yield gap evaluation framework integrated with typical field survey and crop model analysis could provide valuable information for narrowing the yield gap.
Testing the neurodevelopmental, trauma and developmental risk factor models of psychosis using a naturalistic experiment
Authors: Liu Yiwen , Mendonça Marina , Johnson Samantha , O'Reilly Helen , Bartmann Peter , Marlow Neil , Wolke Dieter 
Published: December 2019

AbstractBackgroundThe neurodevelopmental and trauma theories are two widely cited models of psychosis. A third – the developmental risk factor model (DRFM) – recognises the combined role of neurodevelopmental risks and trauma. Our objective was to test these theories using preterm populations as a natural experiment, given the high prevalence of neurodevelopmental deficits and exposure to trauma.MethodsTwo population-based preterm birth cohorts, the Bavarian Longitudinal Study (BLS; N = 399) and EPICure Study (N = 184), were included with term-born controls. Peer victimisation in childhood was assessed by parent and child report and psychotic experiences (PE) were assessed in early adulthood. Different models of psychosis were tested using regression and mediation analyses.ResultsThere was support for the trauma and DRFM in the BLS. Peer victimisation increased the risk of PE for preterm and term-born participants equally [odds ratio = 4.87, 95% confidence interval (CI) 1.96–12.08]. There was an indirect effect where preterm children were more likely to be victimised, which subsequently increased risk of PE [β = 1.12 (s.e. = 0.61), 95% CI 0.11–2.48]. The results were replicated in EPICure.ConclusionsExposure to trauma which is experienced more often by neurodevelopmental risk children rather than neurodevelopmental risk per se increases the risk of PE. The findings are consistent with the trauma model and DRFM. Interventions focused on reducing trauma may reduce the development of PE.
Renewable Energy for Robots and Robots for Renewable Energy – A Review
Authors: Hassan Ahmed A. , El Habrouk Mohamed , Deghedie Samir 
Published: December 2019

SUMMARYFossil fuel sources are well suited to fulfill the energy needs of human beings. Unfortunately, there are some limitations and disadvantages pertaining to fossil fuels, some of which are drastic. The main issues are: firstly, there is a finite supply of these fuels, eventually this supply will be exhausted; secondly, burning fossil fuels contributes to global warming, leading to disastrous consequences for the environment and the health of humans. Switching to renewable energy sources is the viable solution to the aforementioned issues. Robots bring numerous benefits in a wide variety of applications. Introducing robots to production environments and other applications results in a remarkable improvement in terms of productivity and efficiency. In this paper, the integration between robots and renewable energy sources is discussed. In other words, two main points are investigated: (1) how can renewable energy be a viable source of energy for robots and (2) how can the renewable energy industry benefit from utilizing robots in the execution of renewable energy-related tasks. Some of the recent developments concerning the integration between robots and renewable energy are reviewed. In addition, more opportunities and expected advancements are also discussed.
The Effect of Operator Position on the Quality of Chest Compressions Delivered in a Simulated Ambulance
Authors: Mullin Scott , Lydon Sinéad , O’Connor Paul 
Published: December 2019

AbstractBackground:Ambulances are where patient care is often initiated or maintained, but this setting poses safety risks for paramedics. Paramedics have found that in order to optimize patient care, they must compromise their own safety by standing unsecured in a moving ambulance.Hypothesis/Problem:This study sought to compare the quality of chest compressions in the two positions they can be delivered within an ambulance.Methods:A randomized, counterbalanced study was carried out with 24 paramedic students. Simulated chest compressions were performed in a stationary ambulance on a cardiopulmonary resuscitation (CPR) manikin for two minutes from either: (A) an unsecured standing position, or (B) a seated secured position. Participants’ attitudes toward the effectiveness of the two positions were evaluated.Results:The mean total number of chest compressions was not significantly different standing unsecured (220; SD = 12) as compared to seated and secured (224; SD = 21). There was no significant difference in mean compression rate standing unsecured (110 compressions per minute; SD = 6) as compared to seated and secured (113 compressions per minute; SD = 10). Chest compressions performed in the unsecured standing position yielded a significantly greater mean depth (52 mm; SD = 6) than did seated secured (26 mm; SD = 7; P < .001). Additionally, the standing unsecured position produced a significantly higher percentage (83%; SD = 21) for the number of correct compressions, as compared to the seated secured position (8%; SD = 17; P < .001). Participants also believed that chest compressions delivered when standing were more effective than those delivered when seated.Conclusions:The quality of chest compressions delivered from a seated and secured position is inferior to those delivered from an unsecured standing position. There is a need to consider how training, technologies, and ambulance design can impact the quality of chest compressions.
Monitoring and punishment networks in an experimental common pool resource dilemma
Authors: Shreedhar Ganga , Tavoni Alessandro , Marchiori Carmen 
Published: December 2019

AbstractWith the aid of a lab experiment, we explored how imperfect monitoring and punishment networks impacted appropriation, punishment and beliefs in a common pool resource appropriation dilemma. We studied the differences between the complete network (with perfect monitoring and punishment, in which everyone can observe and punish everyone else) and two ‘imperfect’ networks (that systematically reduce the number of subjects who could monitor and punish others): the directed and undirected circle networks. We found that free riders were punished in all treatments, but the network topology impacted the type of punishment: the undirected circle induced more severe punishment and prosocial punishment compared to the other two networks. Both imperfect networks were more efficient because the larger punishment capacity available in the complete network elicited higher punishment amount.
‘Prevent undernutrition and prescribe oral nutritional supplements correctly’: an educational intervention for district nurses
Authors: Samuelsson L. , Södergren M. , Berggren E. , Törnkvist L. 
Published: December 2019

Abstract

Aim:
The aim of this study was to evaluate district nurses’ (DN) perceived nutritional care and actual level of knowledge about nutritional care before and after a continuing educational intervention.

Background:
Nutritional treatment is an important part of nursing care, and health professionals responsible for nutritional care for older adults must therefore have sufficient understanding of nutritional problems to provide appropriate support. Previous research has shown that nutritional problems frequently go unrecognized and that health care personnel often lacks knowledge about nutritional care and relevant methods of assessing nutritional status. However, little is known about DNs’ knowledge about nutritional care.

Methods:
An evaluative study with a study-specific questionnaire administered before and after a 2.5-day continuing educational course for DNs in primary health care in Stockholm County, Sweden. The course was given over a period of two to three months. The questionnaire measured DNs’ perceived nutritional care and actual level of knowledge about nutritional care.

Findings:
A total of 456 DNs completed the questionnaire both before and after the intervention. Participants’ mean age was 50 years. They had worked a mean of 26 years in health care and 10 years as DNs. Before the intervention, many DNs reported that they did not work with nutritional care in an optimal way. After the intervention, significant improvements were found in perceived nutritional care and actual level of knowledge about the topic. However, not all DNs achieved the learning objectives of the course, so work remains to be done to ensure that DNs have sufficient knowledge of nutritional care to provide appropriate support and correctly prescribe oral nutritional supplements.

Conclusions:
The study provides new information on DNs’ perceived nutritional care and actual level of knowledge. The result of the intervention helps lay the foundation for good nutritional care for older patients in primary care.