bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Temperature Deformation Behavior of 718Plus: Consideration of γ′ Effects
Authors: Ozturk Utkudeniz , Cabrera Jose Maria , Calvo Jessica , Redjaïmia Abdelkrim , Ghanbaja Jaâfar 
Published: January 2020

Abstract
The hot deformation behavior of 718Plus is modeled through a physically based hybrid dislocation density model, which includes the effects of precipitating particles. It is well known that the service performance and hot flow characteristics of this alloy are strongly dependent on the microstructure, particularly the grain size and second-phase particles. Thus, comprehension and modeling of the hot flow behavior is an important task. In precipitation hardening alloys (superalloys, microalloyed steels, etc.), it is particularly challenging to model the microstructural evolution in the processing windows, where material softening and precipitation processes take place concurrently. In this work, the initial stages of the deformation are studied. A model based on dislocation density evolution is presented. As in conventional approaches, the dislocation density is considered as a competition between dislocation generation and dynamic recovery at the early stages of deformation. Recovery is assumed to be driven by glide and climb of dislocations, which are considered to be proportional to the strain rate and damped by the existence of second-phase particles. It is known that under high-temperature deformation conditions, 718Plus may undergo dynamic precipitation. Second-phase particles in the material may impede the grain boundary motion and contribute to an increase in flow stress. To account for the dynamic precipitation, the present model combines experimental results and precipitation models to predict volume fraction and particle size. The effect of aging is studied through transmission electron microscopy (TEM) characterization of the specimens from interrupted tests at the onset of dynamic recrystallization. Stress contribution due to different modes of dislocation precipitation interaction are modeled and integrated to the phenomenological dislocation density–based hardening models.
Distinct Populations of Neurons Activated by Heroin and Cocaine in the Striatum as Assessed by catFISH
Authors: Vassilev Philip , Avvisati Riccardo , Koya Eisuke , Badiani Aldo 
Published: January 2020

AbstractDespite the still prevailing notion of a shared substrate of action for all addictive drugs, there is evidence suggesting that opioid and psychostimulant drugs differ substantially in terms of their neurobiological and behavioral effects. These differences may reflect separate neural circuits engaged by the two drugs. Here we used the catFISH (cellular compartment analysis of temporal activity by fluorescencein situhybridization) technique to investigate the degree of overlap between neurons engaged by heroin versus cocaine in adult male Sprague Dawley rats. The catFISH technique is a within-subject procedure that takes advantage of the different transcriptional time course of the immediate-early geneshomer 1aandarcto determine to what extent two stimuli separated by an interval of 25 min engage the same neuronal population. We found that throughout the striatal complex the neuronal populations activated by noncontingent intravenous injections of cocaine (800 μg/kg) and heroin (100 and 200 μg/kg), administered at an interval of 25 min from each other, overlapped to a much lesser extent than in the case of two injections of cocaine (800 μg/kg), also 25 min apart. The greatest reduction in overlap between populations activated by cocaine and heroin was in the dorsomedial and dorsolateral striatum (∼30% and ∼22%, respectively, of the overlap observed for the sequence cocaine–cocaine). Our results point toward a significant separation between neuronal populations activated by heroin and cocaine in the striatal complex. We propose that our findings are a proof of concept that these two drugs are encoded differently in a brain area believed to be a common neurobiological substrate to drug abuse.
INCREASING ACCOUNTABILITY THROUGH INTERNAL CONTROL MECHANISM IN RELIGIOUS ORGANIZATION
Authors: ED Radianto Wirawan , Laturette Kazia 
Published: January 2020

Purpose: This study aims to investigate the implementation of internal control in religious institutions, especially church institutions. A difference in church governance certainly differentiates the church's internal control, so the issue of internal control is very important and interesting for further investigation.
Methodology: This study used a sample of 100 churches. The researchers used questionnaires in data collection. The sampling method used is the purposive sampling method. To see whether there are differences in internal control between different church governance styles, the researchers used the chi-square analysis.
Results: The findings of this study are as follows: all churches have realized the importance of accountability that must be held to gain the trust of their congregants. Hence, all churches sampled in this study already have an internal control system. This study found differences in the systems based on church governance. Therefore, it is known that governance differentiates churches’ internal control systems.
Implications: The implication of this research is that a church must have an effective internal control system. This is necessary because the church must be accountable to all of its stakeholders, especially the church congregants. The implementation of the internal control system may differ according to the church management system. However, the elements of the internal control system must be the same even though the process of implementing the internal control system is different.
Maternal Emotions and Experiences of Mothers Who Had Breastfeeding Problems: A Qualitative Study
Authors: Durmazoğlu Gamze , Yenal Kerziban , Okumuş Hülya 
Published: January 2020

Background and PurposeMany women are ceasing to breastfeed in the early period due to the breastfeeding problems and difficulties they perceive. Consequently, the approach and support of health professionals to mothers in the post-partum period is very important. The objective of the study is to determine the emotions and experiences of mothers who had breastfeeding problems by using Watson's Theory of Human Caring.MethodsThe research is a descriptive and qualitative type of study. The data were collected from 20 women with the semi-structured interview method based on Watson's Theory. The data were analyzed according to the Caritas Processes of Watson's Theory.ResultsIt was determined that the health professionals did not show enough assistance, support and interest to the mothers who had breastfeeding problems and that the mothers expected respect, empathy, sincerity, understanding, trust, and assistance during this period.Implication for PracticeThe use of the interview methods based on Watson's Theory of Human Caring in the determination of the difficulties and emotions experienced by the women who had breastfeeding problems will be a guide for the health professionals. It is thought that the approaches based on Watson's Caritas Processes that would be made to women who had breastfeeding problems would be effective for understanding their experience and emotions.
Guidance for the Reporting of an Intervention's Theory
Authors: Sidani Souraya , Fox Mary , El-Masri Maher M. 
Published: January 2020

BackgroundInterventions in clinical trials should be clearly and completely described to inform their evaluation in replication studies and implementation in clinical practice. Guidelines were developed to standardize the reporting of interventions, but failed to provide guidance on reporting of the theory of interventions. Further, space constraints imposed by many research journals often limit the comprehensive description of both the theoretical and operational aspects of interventions.PurposeTo address these gaps, we propose that the theory of interventions be published in separate conceptual papers that would provide an in-depth description of the health problem targeted by an intervention, the components comprising an intervention, the causal mechanism responsible for an intervention's impact on the outcomes, and the conditions necessary for the proper implementation and the effectiveness of an intervention.ImplicationsSuch papers would assist in the critical appraisal of the adequacy, implementation, and evaluation of interventions. A description of the theory of interventions clarifies to health professionals what the interventions are about, who is likely to benefit from the interventions, how the interventions work and under what context.
Análise da relevância da propriedade semântica "reciprocidade" nos verbos recíprocos intransitivos do Português Brasileiro
Authors: Bechir Thaís Fernanda Carvalho 
Published: January 2020

Os verbos recíprocos (VR) são tratados como uma classe na literatura por possuírem uma propriedade semântica – a reciprocidade – que licencia uma composição sintática: a alternância simples-descontínua. Nesta composição, os eventos denotados pelos verbos podem alternar entre as formas simples, em que os participantes da reciprocidade são denotados por apenas um argumento (João e Maria conversaram), e descontínua, em que os participantes são denotados por dois argumentos, sendo um deles preposicionado (João conversou com Maria). Objetivamos analisar os VR intransitivos e verificar se eles podem ser agrupados em uma só classe no português brasileiro. Intencionamos propor representações semânticas para as classes encontradas, valendo-nos da decomposição de predicados, além de apresentar uma discussãoacerca do estatuto da propriedade semântica reciprocidade. Propusemos duas estruturas de decomposição de predicados para os VR intransitivos analisados, demonstrando que eles pertencem a duas classes distintas. Concluímos que os VR não formam uma classe e que a propriedade de reciprocidade, apesar de fazer parte do sentido idiossincrático de alguns verbos, é gramaticalmente irrelevante
Knowledge regarding antibiotic use among students of three medical schools in Medellin, Colombia: A cross-sectional study
Authors: Hguita-Gutiérrez Luis Felipe , Molina Valentina , Acevedo Jenifer María , Gómez Liceth , Villamil Gustavo Eduardo Roncancio , Quiceno Judy Natalia Jiménez 
Published: January 2020

Abstract
Background The objective of the present study was to describe the knowledge regarding the antibiotic therapy of students of three medical schools in Medellín, Colombia. Methods The study population comprised medical students who were enrolled in three universities. The instrument contained questions regarding their current academic term, the university, the perceived quality of the education received on antibiotic therapy and bacterial resistance, and specific questions on upper respiratory tract infections, pneumonia, urinary tract infections, and skin and soft tissue infections. The information was analyzed by calculating frequencies and measures of dispersion and central tendency. Knowledge regarding the treatment for each type of infection was compared using the Mann–Whitney U test and the Kruskal–Wallis H test. Results We included 536 medical students, of which 43.5% students consider that the university has not sufficiently trained them to interpret antibiograms and 29.6% students consider that the quality of information received on the subject at their university ranges from regular to poor. The mean score for knowledge regarding antibiotic therapy for upper respiratory tract infections was 44.2 (9.9) on a scale from 0 to 100. The median score with regard to the treatment of pneumonia was 52.9 (14.7), that of urinary tract infection was 58.7 (14.8), and that of skin and soft tissue infections was 63.1 (19.4). The knowledge regarding antibiotic therapy for upper respiratory tract infections, pneumonia, and urinary tract infection does not improve with the academic term, the university, or perceived quality of the education received. Conclusion A large proportion of medical students perceive that the training received from the university is insufficient with regard to antibiotic use and bacterial resistance, which is consistent with the limited knowledge reflected in the selection of antibiotic treatment for respiratory, urinary tract, and skin and soft tissue infections. Overall, the situation was identical among all universities, and it did not significantly increase with the completion of an academic term.
Genome-wide analysis of long non-coding RNAs (lncRNAs) in two contrasting rapeseed (Brassica napus L.) genotypes subjected to drought stress and re-watering
Authors: Tan Xiaoyu , Li Su , Hu Liyong , Zhang Chunlei 
Published: January 2020

Abstract
Background: Drought stress is a major abiotic factor that affects rapeseed (Brassica napus L.) productivity. Though previous studies indicated that long non-coding RNAs (lncRNAs) play a key role in response to drought stress, a scheme for genome-wide identification and characterization of lncRNAs’ response to drought stress is still lacking, especially in the case of B. napus. In order to further understand the molecular mechanism of the response of B. napus to drought stress, we compared changes in the transcriptome between Q2 (a drought-tolerant genotype) and Qinyou8 (a drought-sensitive genotype) in response to drought stress and rehydration treatment at the seedling stage.

Results: A total of 5,546 down-regulated and 6,997 up-regulated mRNAs were detected in Q2 compared with 7,824 and 10,251 in Qinyou8, respectively; 369 down-regulated and 108 up-regulated lncRNAs were detected in Q2 compared with 449 and 257 in Qinyou8, respectively. LncRNA- mRNA interaction network analysis indicated that the co-expression network of Q2 was composed of 145 network nodes and 5,175 connections, while the co-expression network of Qinyou8 was composed of 305 network nodes and 22,327 connections. We further identified 34 TFs corresponding to 126 differentially expressed lncRNAs in Q2, and 45 TFs corresponding to 359 differentially expressed lncRNAs in Qinyou8. Differential expression analysis of lncRNAs indicated that up- and down-regulated mRNAs co-expressed with lncRNAs participated in different metabolic pathways and were involved in different regulatory mechanisms in the two genotypes. Notably, some lncRNAs were co-expressed with BnaC07g44670D, which are associated with plant hormone signal transduction. Additionally, some mRNAs which were co-located with XLOC_052298, XLOC_094954 and XLOC_012868 were mainly categorized as signal transport and defense/stress response.

Conclusions: The results of this study increased our understanding of expression characterization of rapeseed lncRNAs in response to drought stress and re-watering, which would be useful to provide a reference for the further study of the function and action mechanisms of lncRNAs under drought stress and re-watering.
Potential biomarkers of ductal carcinoma in situ progression
Authors: Dettogni Raquel Spinassé , Stur Elaine , Laus Ana Carolina , Vieira René Aloísio da Costa , Marques Márcia Maria Chiquitelli , Santana Iara Viana Vidigal , Pulido José Zago , Ribeiro Laura Fregonassi , Parmanhani Narelle de Jesus , Agostini Lidiane Pignaton , Reis Raquel Silva dos , Santos Eldamária de Vargas Wolfgramm , Alves Lyvia Neves Rebello , Garcia Fernanda Mariano , Santos Jéssica Aflávio , Ventorim Diego do Prado , Reis Rui Manuel , Louro Iúri Drumond 
Published: January 2020

Abstract
Background Ductal carcinoma in situ is a non-obligate precursor of invasive breast carcinoma and presents a potential risk of over or undertreatment. Finding molecular biomarkers of disease progression could allow for more adequate patient treatment. We aimed to identify potential biomarkers that can predict invasiveness risk.Methods In this epithelial cell-based study archival formalin-fixed paraffin-embedded blocks from six patients diagnosed with invasive lesions (pure invasive ductal carcinoma), six with in-situ lesions (pure ductal carcinoma in situ) , six with synchronous lesions (invasive ductal carcinoma with an in-situ component) and three non-neoplastic breast epithelium tissues were analyzed by gene expression profiling of 770 genes, using the nCounter® PanCancer Pathways panel of NanoString Technologies. Results The results showed that in comparison with non-neoplastic tissue the pure ductal carcinoma in situ was one with the most altered gene expression profile. Comparing pure ductal carcinoma in situ and in-situ component six differentially expressed genes were found, three of them ( FGF2 , GAS1, and SFRP1 ), play a role in cell invasiveness. Importantly, these genes were also differentially expressed between invasive and noninvasive groups and were negatively regulated in later stages of carcinogenesis. Conclusions We propose these three genes ( FGF2 , GAS1, and SFRP1 ) as potential biomarkers of ductal carcinoma in situ progression, suggesting that their downregulation may be involved in the transition of stationary to migrating invasive epithelial cells.
Tick-borne pathogens in Ixodidae ticks collected from privately-owned dogs in Italy: a country-wide molecular survey
Authors: Zanet Stefania , Battisti Elena , Pepe Paola , Ciuca Lavinia , Colombo Liliana , Trisciuoglio Anna , Ferroglio Ezio , Cringoli Giuseppe , Rinaldi Laura , Maurelli Maria Paola 
Published: January 2020

Abstract

Background
Ticks and tick-borne diseases are increasingly recognized as a cause of disease in dogs worldwide. The epidemiology of ticks and tick-transmitted protozoa and bacteria has changed due to the spread of ticks to urban and peri-urban areas and the movement of infected animals, posing new risks for animals and humans. This countrywide study reports information on distribution and prevalence of pathogens in ticks collected from privately-owned dogs in Italy.
We analyzed 2681 Ixodidae ticks, collected from 1454 pet dogs from Italy. Specific PCR protocols were used to detect i) Piroplasms of the genera Babesia and Theileria , ii) Gram-negative cocci of the family Anaplasmataceae and iii) Borrelia burgdorferi sensu lato. Sequencing of positive amplicons allowed for species identification.
Results
Babesia / Theileria spp. DNA was detected in 435 homogeneous tick-pools (Minimum Infection Rate (MIR) = 27.6%; 95% confidence interval (CI) = 25.4-29.8%) with higher prevalence in Ixodes ricinus and Rhipicephalus sanguneus group. The zoonotic B. venatorum was the most prevalent species (MIR = 7.5%; 95% CI = 6.3-9.0%). Anaplasma and Ehrlichia species were detected in 165 tick-pools (MIR = 10.5%; 95% CI = 9.3-11.8%) and specifically, A. phagocytophilum was identified with MIR = 5.1% (95% CI = 4.1-6.3%). Borrelia burgdorferi s.l. and B. afzelii were detected with MIR = 0.4% (95% CI = 0.2-0.8%) and MIR = 0.3% (95% CI 0.1-0.7%) respectively.
Conclusions
Zoonotic pathogens B. venatorum and A. phagocytophilum were the most frequently detected in ticks collected from privately-owned dogs which might be used as markers of pathogens presence and distribution.
Relationship between fluoroquinolones and the risk of aortic diseases: a meta-analysis of observational studies
Authors: Dai Xiao-ce , Yang Xin-xin , Ma Lan , Tang Guan-min , Pan Yan-yun , Hu Hui-lin 
Published: January 2020

Abstract
Background. Our aim was to determine the relationship between the use of fluoroquinolones and the risk of aortic diseases.
Methods. PubMed, EMBASE and the Web of Science were searched from inception to July 6, 2019, to identify observational studies that evaluated the risk of aortic diseases associated in users of fluoroquinolones compared with nonusers or users of other antibiotics. The primary outcome was the first occurrence of aortic diseases. We used the GRADE approach to rate the strength of evidence. We used the inverse variance method random-effect model to estimate the odds ratios (ORs) with 95% CIs, and statistical heterogeneity was assessed by the I 2 statistic.
Results. This meta-analysis enrolled 2,829,385 patients reported the relationship between fluoroquinolones and the risk of aortic diseases. Compared with nonusers or users of other antibiotics, users of fluoroquinolone had a significantly increased risk of aortic diseases (adjusted OR, 2.10; 95% CI, 1.65-2.68; P =.000, I 2 =16.4%). The quality of evidence was moderate, and the number needed to harm (NNH) for aortic diseases among patients was estimated to be 1301.
Conclusions. The fluoroquinolone use in patients significantly increases the risk of new-onset aortic diseases. Clinicians need to pay attention to these severe adverse events when considering fluoroquinolone use.
Key Words: Fluoroquinolones; aortic aneurysm; aortic dissection; meta-analysis
A novel virtual barcode strategy for accurate panel-wide variant calling in circulating tumor DNA
Authors: wu leilei , Deng Qinfang , Xu Ze , Zhou Songwen , Li Chao , Li yixue 
Published: January 2020

AbstractBackground Hybrid capture-based next-generation sequencing of DNA has been widely applied in the detection of circulating tumor DNA (ctDNA). Various methods have been proposed for ctDNA detection, but low-allelic-fraction (AF) variants are still a great challenge. In addition, no panel-wide calling algorithm is available, which hiders the full usage of ctDNA based ‘liquid biopsy’. Thus, we developed the VBCALAVD (Virtual Barcode-based Calling Algorithm for Low Allelic Variant Detection) i n silico to overcome these limitations. Results Based on the understanding of the nature of ctDNA fragmentation, a novel platform-independent virtual barcode strategy was established to eliminate random sequencing errors by clustering sequencing reads into virtual families.Stereotypical mutant-family-level background artifacts were polished by constructing AF distributions. Three additional robust fine-tuning filters were obtained to eliminate stochastic mutant-family-level noises. The performance of our algorithm was validated using cell-free DNA reference standard samples (cfDNA RSDs) and normal healthy cfDNA samples (cfDNA controls). For the RSDs with AFs of 0.1%, 0.2%, 0.5%, 1% and 5%, the mean F1 scores were 0.43 (0.25~0.56), 0.77, 0.92, 0.926 (0.86~1.0) and 0.89 (0.75~1.0), respectively, which indicates that the proposed approach significantly outperforms the published algorithms. Among controls, no false positives were detected. Meanwhile, characteristics of mutant-family-level noise and quantitative determinants of divergence between mutant-family-level noises from controls and RSDs were clearly depicted. Conclusions Due to its good performance in the detection of low-AF variants, our algorithm will greatly facilitate the noninvasive panel-wide detection of ctDNA in research and clinical settings. The whole pipeline is available at https://github.com/zhaodalv/VBCALAVD.