bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new lower and upper bound estimation model using gradient descend training method for wind speed interval prediction
Authors: Liu Fangjie , Li Chaoshun , Xu Yanhe , Tang Geng , Xie Yuying 
Published: October 2020

AbstractAs a clean and renewable energy source, wind energy has achieved remarkable growth around the world. Wind power/speed interval prediction has become an indispensable area of focus regarding the efficient dispatch of wind energy. As an important interval prediction method, the traditional lower and upper bound estimation (LUBE) has been a prevalent approach and a fundamental branch of energy prediction. However, the traditional LUBE model suffers from a low training efficiency owing to a lack of the gradient descent (GD) training mechanism. In this study, an improved LUBE model was designed using a novel training scheme based on the GD method for better efficiency and greater prediction performance. Initially, the new objective functions, which are continuous and differential, meeting the requirements of the GD method, were designed to obtain the best prediction interval (PI) quality with a narrower PI width and greater coverage probability. Then, different loss function forms have been proposed and compared, with the new Huber loss function having been confirmed to be more effective than other traditional loss functions. Finally, the new LUBE model with an objective part and adapting to the GD training method was constructed. Both traditional and improved LUBE models with different loss functions were compared experimentally, and the results indicate that the improved LUBE model with a Huber loss function significantly reduces the training time and improves the quality of the PI.
Structural repair of wind turbine blades: Computational model for the evaluation of the effect of adhesive properties
Authors: Mischnaewski Lennart , Mishnaevsky Leon 
Published: October 2020

AbstractThree‐dimensional (3‐D) finite element models of structural (scarf) repair of wind turbine blade, including the composite patch, adhesive, coating and parent composite structures is developed. Computational studies of the effect of the scarf angle, thickness of the adhesive layer and the availability of voids in the adhesive on the stress field in the repaired structure were carried out. It is observed that the soft adhesives lead to increased stresses in the parent laminate structures. The availability of voids in the adhesive leads to local stress concentration, and thus can reduce the postrepair reliability of the blades.
Generalized Schur–Nevanlinna functions and their realizations
Authors: Lilleberg Lassi 
Published: October 2020

AbstractPontryagin space operator valued generalized Schur functions and generalized Nevanlinna functions are investigated by using discrete-time systems, or operator colligations, and state space realizations. It is shown that generalized Schur functions have strong radial limit values almost everywhere on the unit circle. These limit values are contractive with respect to the indefinite inner product, which allows one to generalize the notion of an inner function to Pontryagin space operator valued setting. Transfer functions of self-adjoint systems such that their state spaces are Pontryagin spaces, are generalized Nevanlinna functions, and symmetric generalized Schur functions can be realized as transfer functions of self-adjoint systems with Kreĭn spaces as state spaces. A criterion when a symmetric generalized Schur function is also a generalized Nevanlinna function is given. The criterion involves the negative index of the weak similarity mapping between an optimal minimal realization and its dual. In the special case corresponding to the generalization of an inner function, a concrete model for the weak similarity mapping can be obtained by using the canonical realizations.
Macroporous epoxy-based monoliths for rapid quantification of Pseudomonas aeruginosa by adsorption elution method optimized for qPCR
Authors: Göpfert Lisa , Klüpfel Julia , Heinritz Charlotte , Elsner Martin , Seidel Michael 
Published: October 2020

AbstractPseudomonas aeruginosa contaminations in tap water systems have caused severe health problems in both hospital and household settings. To ensure fast and reliable detection, culture-independent methods are recommendable. However, the typically low cell number in water samples requires sample enrichment prior to analysis. Therefore, we developed and optimized an adsorption elution method using monolithic adsorption filtration and subsequent centrifugal ultrafiltration that can be combined with culture-independent detection methods. The principle of adsorption of Pseudomonas aeruginosa by hydrophobic and ionic interactions was studied in modified epoxy-based monoliths. Optimized conditions (5-L initial sample volume at pH 3 filtered for 30 min through hydrolyzed monoliths (MAF-OH) and eluted with beef extract glycine buffer at pH 9.5) achieved a recovery of 67.1 ± 1.2% and a concentration factor of 103. For the first time, we therefore present a culture-independent approach for rapid enrichment and subsequent molecular biological quantification of P. aeruginosa by qPCR from tap water samples by monolithic adsorption filtration. The total enrichment and quantification process takes 4 h. This work further stresses the versatility of the monolithic adsorption filtration and its possibilities as a concentration tool for culture-independent analytics of pathogenic bacteria in the environment.Graphical abstract
The role of ulnar nerve subcutaneous anterior transposition during open reduction and internal fixation of distal humerus fractures: a retrospective cohort study
Authors: Ahmed Abdulaziz F. , Parambathkandi Ashik Mohsin , Kong Wai Jing Geraldine , Salameh Motasem , Mudawi Aiman , Abousamhadaneh Maamoun , Abuodeh Yousef , Ahmed Ghalib O. 
Published: October 2020

Abstract
Purpose
To compare the rates of ulnar nerve neuropathy following ulnar nerve subcutaneous anterior transposition versus no transposition during open reduction and internal fixation (ORIF) of distal humerus fractures.

Methods
This was a retrospective cohort study at an academic level I trauma centre. A total of 97 consecutive patients with distal humerus fractures underwent ORIF between 2011 and 2018. All included patients were treated with plates (isolated lateral plates excluded) and had no pre-operative ulnar neuropathy. Subcutaneous ulnar nerve anterior transposition was compared versus no transposition at the time of ORIF. The main outcome measure was the rate of ulnar nerve neuropathy. The secondary outcomes were the severity of the ulnar nerve neuropathy and the rate of ulnar nerve recovery.

Results
Twenty-eight patients underwent subcutaneous ulnar nerve anterior transposition during ORIF, whereas 69 patients had no transposition. Transposition was associated with significantly higher rates of ulnar nerve neuropathy (10/28 versus 10/69; P = 0.027). An adjusted logistic regression model demonstrated an odds ratio of 4.8 (1.3, 17.5; 95% CI) when transposition was performed. Ulnar nerve neuropathy was classified as McGowan grades 1 and 2 in all neuropathy cases in both groups (P = 0.66). Three out of ten cases recovered in the transposition group, and five out of ten cases recovered in the no transposition group over a mean follow-up of 11.2 months (P = 1.00).

Conclusion
We do not recommend performing routine subcutaneous ulnar nerve anterior transposition during ORIF of distal humerus fracture as it was associated with a significant 5-fold increase in ulnar nerve neuropathy.
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology
Authors: Golebiewska Anna , Hau Ann-Christin , Oudin Anaïs , Stieber Daniel , Yabo Yahaya A. , Baus Virginie , Barthelemy Vanessa , Klein Eliane , Bougnaud Sébastien , Keunen Olivier , Wantz May , Michelucci Alessandro , Neirinckx Virginie , Muller Arnaud , Kaoma Tony , Nazarov Petr V. , Azuaje Francisco , De Falco Alfonso , Flies Ben , Richart Lorraine , Poovathingal Suresh , Arns Thais , Grzyb Kamil , Mock Andreas , Herold-Mende Christel , Steino Anne , Brown Dennis , May Patrick , Miletic Hrvoje , Malta Tathiane M. , Noushmehr Houtan , Kwon Yong-Jun , Jahn Winnie , Klink Barbara , Tanner Georgette , Stead Lucy F. , Mittelbronn Michel , Skupin Alexander , Hertel Frank , Bjerkvig Rolf , Niclou Simone P. 
Published: October 2020

AbstractPatient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, including gliomas with mutations inIDH1, and paired longitudinal PDOX from primary and recurrent tumors of the same patient. We show that glioma PDOXs enable long-term propagation of patient tumors and represent clinically relevant patient avatars that retain histopathological, genetic, epigenetic, and transcriptomic features of parental tumors. We find no evidence of mouse-specific clonal evolution in glioma PDOXs. Our cohort captures individual molecular genotypes for precision medicine including mutations inIDH1,ATRX,TP53,MDM2/4, amplification ofEGFR,PDGFRA,MET,CDK4/6,MDM2/4, and deletion ofCDKN2A/B,PTCH, andPTEN. Matched longitudinal PDOX recapitulate the limited genetic evolution of gliomas observed in patients following treatment. At the histological level, we observe increased vascularization in the rat host as compared to mice. PDOX-derived standardized glioma organoids are amenable to high-throughput drug screens that can be validated in mice. We show clinically relevant responses to temozolomide (TMZ) and to targeted treatments, such as EGFR and CDK4/6 inhibitors in (epi)genetically defined subgroups, according toMGMTpromoter andEGFR/CDKstatus, respectively. Dianhydrogalactitol (VAL-083), a promising bifunctional alkylating agent in the current clinical trial, displayed high therapeutic efficacy, and was able to overcome TMZ resistance in glioblastoma. Our work underscores the clinical relevance of glioma organoids and PDOX models for translational research and personalized treatment studies and represents a unique publicly available resource for precision oncology.
Impact of frailty on the management of patients with gynecological cancer aged 80 years and older
Authors: Reiser Elisabeth , Pötsch Nina , Seebacher Veronika , Reinthaller Alexander , Wimazal Friedrich , Fleischmann Edith , Krainer Michael , Horvat Reinhart , Polterauer Stephan , Grimm Christoph 
Published: October 2020

Abstract
Purpose
To assess the impact of frailty on compliance of standard therapy, complication, rate and survival in patients with gynecological malignancy aged 80 years and older.

Methods
In total, 83 women with gynecological malignancy (vulva, endometrial, ovarian or cervical cancer) who underwent primary treatment between 2007 and 2017 were retrospectively analyzed. Frailty index was calculated and its association with compliance of standard treatment, peri- and postoperative mortality and morbidity, and survival was evaluated.

Results
Frailty was observed in 24.1% of cases. Both frail and non-frail patients were able to receive standard therapy in most cases − 75.0% and 85.7%, respectively (p = 0.27). Frail patients did not show an increased postoperative complication rate. Frail patients had shorter 3 years overall survival rates (28%) when compared to non-frail patients (55%) (p = 0.02). In multivariable analysis high frailty index (Hazard Ratio [HR] 12.15 [1.39–106.05], p = 0.02) and advanced tumor stage (HR 1.33 [1.00–1.76], p = 0.05) were associated with poor overall survival, but not age, histologic grading, performance status, and compliance of standard therapy.

Conclusion
Majority of patients was able to receive standard therapy, as suggested by the tumor board, irrespective of age and frailty. Nonetheless, frailty is a common finding in patients with gynecological malignancy aged 80 years and older. Frail patients show shorter progression-free, and overall survival within this cohort.
Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?
Authors: Spiegel Jennifer L. , Jakob Mark , Kruizenga Marie , Freytag Saskia , Bertlich Mattis , Canis Martin , Ihler Friedrich , Haubner Frank , Kitz Julia , Weiss Bernhard G. 
Published: October 2020

Abstract
Purpose
Adenocarcinoma of the salivary glands is of low incidence and a broad range of histopathological subtypes. Cancer stem cell markers (CSC) might serve as novel prognostic parameters. To date, only a few studies examined the expression of CSC in adenocarcinoma of the salivary glands with diverging results. To further investigate the reliability in terms of prognostic value, a histopathological analysis of CSCs on a cohort of patients with adenocarcinomas of the major salivary glands was performed.

Methods
Tumor samples of 40 consecutive patients with adenocarcinoma of the major salivary gland treated with curative intend at one tertiary center were stained with the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2. Expression of these markers was correlated with clinicopathological parameters and survival estimates.

Results
Correlation of high expression of ALDH1 with higher grading (p < 0.001) and high expression of CD44 with the localization of the neoplasm (p = 0.05), larger tumor size (p = 0.006), positive pN-category (p = 0.023), and advanced UICC stage (p = 0.002) was found. Furthermore, high expression of SOX2 correlated with a negative perineural invasion (p = 0.02). No significant correlation of any investigated marker with survival estimates was observed.

Conclusion
In conclusion, our study did not find a significant correlation of the investigated CSCs with survival estimates in adenocarcinoma of the major salivary glands. Recapitulating the results of our study in conjunction with data in the literature, the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2 do not seem to serve as reliable prognostic parameters in the treatment of adenocarcinoma of the salivary glands.
Case report of a cervical myelomalacia caused by a thoracolumbar intradural disc herniation leading to intracranial hypotension
Authors: Ueberschaer M. , Patzig M. , Mueller K. , Schwarting J. , Trabold R. , Tonn J.-C. 
Published: October 2020

AbstractA 50-year-old patient was admitted with symptoms of intracranial hypotension. MRI revealed a cervical myelomalacia caused by engorged epidural veins leading to a stenosis of the spinal canal. This condition is rarely described in patients with hydrocephalus and ventricular shunts suffering from chronic overdrainage. However, the reason in this patient was a CSF leak caused by an intradural disc herniation at T12/L1. After surgery, symptoms resolved and the cervical myelomalacia and the swollen epidural veins disappeared on postoperative MRI.
In patients with engorged cervical epidural veins without a ventricular shunt, a CSF leak has to be considered.
Plant population and soil origin effects on rhizosphere nematode community composition of a range-expanding plant species and a native congener
Authors: Wilschut Rutger A. , Magnée Kim J. H. , Geisen S. , van der Putten W. H. , Kostenko O. 
Published: October 2020

AbstractClimate change causes species range expansions to higher latitudes and altitudes. It is expected that, due to differences in dispersal abilities between plants and soil biota, range-expanding plant species will become associated with a partly new belowground community in their expanded range. Theory on biological invasions predicts that outside their native range, range-expanding plant species may be released from specialist natural enemies, leading to the evolution of enhanced defence against generalist enemies. Here we tested the hypothesis that expanded range populations of the range-expanding plant species Centaurea stoebe accumulate fewer root-feeding nematodes than populations from the original range. Moreover, we examined whether Centaurea stoebe accumulates fewer root-feeding nematodes in expanded range soil than in original range soil. We grew plants from three expanded range and three original range populations of C. stoebe in soil from the original and from the new range. We compared nematode communities of C. stoebe with those of C. jacea, a congeneric species native to both ranges. Our results show that expanded range populations of C. stoebe did not accumulate fewer root-feeding nematodes than populations from the original range, but that C. stoebe, unlike C. jacea, accumulated fewest root-feeding nematodes in expanded range soil. Moreover, when we examined other nematode feeding groups, we found intra-specific plant population effects on all these groups. We conclude that range-expanding plant populations from the expanded range were not better defended against root-feeding nematodes than populations from the original range, but that C. stoebe might experience partial belowground enemy release.
Approximation Guarantee of OSP Mechanisms: The Case of Machine Scheduling and Facility Location
Authors: Ferraioli Diodato , Ventre Carmine 
Published: October 2020

AbstractObvious strategyproofness (OSP) is an appealing concept as it allows to maintain incentive compatibility even in the presence of agents that are not fully rational, i.e., those who struggle with contingent reasoning (Li in Am Econ Rev 107(11):3257–3287, 2017). However, it has been shown to impose some limitations, e.g., no OSP mechanism can return a stable matching (Ashlagi and Gonczarowski in J Econ Theory 177:405–425, 2018). We here deepen the study of the limitations of OSP mechanisms by looking at their approximation guarantees for basic optimization problems paradigmatic of the area, i.e., machine scheduling and facility location. We prove a number of bounds on the approximation guarantee of OSP mechanisms, which show that OSP can come at a significant cost. However, rather surprisingly, we prove that OSP mechanisms can return optimal solutions when they use monitoring—a novel mechanism design paradigm that introduces a mild level of scrutiny on agents’ declarations (Kovács et al. in WINE 9470:398–412, 2015).
Use of fractal models to define the scaling behavior of the aquifers’ parameters at the mesoscale
Authors: Fallico C. , De Bartolo S. , Brunetti G. F. A. , Severino G. 
Published: October 2020

AbstractWe present an experimental study aiming at the identification of the hydraulic conductivity in an aquifer which was packed according to four different configurations. The conductivity was estimated by means of slug tests, whereas the other parameters were determined by the grain size analysis. Prior to the fractal we considered the dependence of the conductivity upon the porosity through a power (scaling) law which was found in a very good agreement within the range from the laboratory to the meso-scale. The dependence of the conductivity through the porosity was investigated by identifying the proper fractal model. Results obtained provide valuable indications about the behavior, among the others, of the tortuosity, a parameter playing a crucial role in the dispersion phenomena taking place in the aquifers.
Self-reported late effects and long-term follow-up care among 1889 long-term Norwegian Childhood, Adolescent, and Young Adult Cancer Survivors (the NOR-CAYACS study)
Authors: Mellblom A. V. , Kiserud C. E. , Rueegg C. S. , Ruud E. , Loge J. H. , Fosså S. D. , Lie Hanne C. 
Published: October 2020

Abstract
Purpose
The majority of childhood, adolescent, and young adult cancer survivors (CAYACS) are at risk of late effects but may not receive long-term follow-up care for these. Here, we investigated (1) self-reported late effects, (2) long-term follow-up care, and (3) factors associated with receiving follow-up care in a population-based sample of Norwegian long-term CAYACS.

Methods
Survivors were identified by the Cancer Registry of Norway. All > 5-year survivors diagnosed between 1985 and 2009 with childhood cancer (CCS, 0–18 years old, excluding CNS), breast cancer (BC, stages I–III), colorectal cancer (CRC), leukemias (LEUK), non-Hodgkin lymphoma (NHL), or malignant melanoma (MM) at age 19–39 years were mailed a questionnaire (NOR-CAYACS study). Descriptive statistics and logistic regression models were used to analyze occurrence of late effects, long-term follow-up care for these, and associated factors.

Results
Of 2104 responding survivors, 1889 were eligible for analyses. Of these, 68% were females, with a mean age of 43 years at survey, on average 17 years since diagnosis, and diagnosed with CCS (31%), BC (26%), CRC (8%), NHL (12%), LEUK (7%), and MM (16%). Overall, 61.5% reported the experience of at least one late effect, the most common being concentration/memory problems (28.1%) and fatigue (25.2%). Sixty-nine percent reported not having received long-term follow-up care focusing on late effects. Lower age at survey (p = 0.001), higher education (p = 0.012), and increasing number of late effects (p = < 0.001) were associated with increased likelihood of follow-up care in the multivariate model.

Conclusions
The majority of survivors reported at least one late effect, but not receiving specific follow-up care for these. This indicates a need for structured models of long-term follow-up to ensure adequate access to care.
Convert index trading to option strategies via LSTM architecture
Authors: Wu Jimmy Ming-Tai , Wu Mu-En , Hung Pang-Jen , Hassan Mohammad Mehedi , Fortino Giancarlo 
Published: October 2020

AbstractIn the past, most strategies were mainly designed to focus on stocks or futures as the trading target. However, due to the enormous number of companies in the market, it is not easy to select a set of stocks or futures for investment. By investigating each company’s financial situation and the trend of the overall financial market, people can invest precisely in the market and choose to go long or short. Moreover, how to determine the position size of the transaction is also a problematic issue. In the past, many money management theories were based on the Kelly criterion. And they put a certain percentage of their total funds into the market for trading. Nonetheless, three massive problems cannot be overcome. First, futures are leveraged transactions, and extra funds must be deposited as margin. It causes that the position size is hard to be estimated by the Kelly criterion. The second point is that the trading strategy is difficult to determine the winning rate in the financial market and cannot be brought into the Kelly criterion to calculate the optimal fraction. Last, the financial data are always massive. A big data technique should be applied to resolve this issue and enhance the performance of the framework to reveal knowledge in the financial data. Therefore, in this paper, a concept of converting the original futures trading strategy into options trading is proposed. An LSTM (long short-term memory)-based framework is proposed to predict the profit probability of the original futures strategy and convert the corresponding daily take-profit and stop-loss points according to the delta value of the options. Finally, the proposed framework brings the results into the Kelly criterion to get the optimal fraction of options trading. The final research results show that options trading is closer to the optimal fraction calculated by the Kelly criterion than futures trading. If the original futures trading strategy can profit, the benefits after converting to options trading can be further superior.