bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terminal deletion of chromosome 13 in a fetus with normal NIPT: The added value of invasive prenatal diagnosis in the NIPT era
Authors: Vervecken Evy , Blaumeiser Bettina , Vanderheyden Tina , Hauspy Jan , Janssens Katrien 
Published: May 2020

AbstractIn the age of noninvasive prenatal testing, there is still an important role for invasive prenatal diagnosis, even for chromosomes 13, 18, and 21.
Second Sphere Ligand Promoted Organoiridium Catalysts for Methanol Dehydrogenation under Mild Conditions
Authors: Bai Chuang , Wang Huihui , Ning Fandi , Fu Junhao , Wei Jun , Lu Guanbin , Shen Yangbin , Zhou Xiaochun 
Published: May 2020

AbstractHydrogen produced from renewable resources is a potential source of clean energy. And Methanol is a liquid at room temperature and has a hydrogen content of up to 12.6 wt%, makes it a promising hydrogen source and can provide great benefits for sustainable hydrogen production. In this work, the modification of the picolinic acid ligand along with changes in the type and substituent position of the groups enhances the activity in iridium‐catalyzed methanol dehydrogenation catalysis. These second sphere ligand modifications are found to be effective for achieving highly active organoiridium catalysts for methanol dehydrogenation reaction under mild conditions, i. e. 1 atm, 78 °C, with a weak base and without using an organic solvent, exhibiting a TOF of 377 h−1. The electronic population analysis of each ligand is theoretically calculated, which shows that catalytic activity is dramatically affected by modifications to the metal's secondary coordination sphere environment, and the high activity originates from appropriate coordination by the picolinic acid ligand and carboxylic acid moiety in addition to the hydroxyl functionality. Moreover, kinetic experiments suggest that the C−H bond of methanol is linked to the iridium core and broken in the rate‐determining step of the reaction. This study will be valuable for catalyst development in the field of methanol dehydrogenation.
Significance of tumour regression in lymph node metastases of gastric and gastro‐oesophageal junction adenocarcinomas
Authors: Reim Daniel , Novotny Alexander , Friess Helmut , Slotta‐Huspenina Julia , Weichert Wilko , Ott Katja , Dislich Bastian , Lorenzen Sylvie , Becker Karen , Langer Rupert 
Published: May 2020

AbstractThe presence of lymph node (LN) metastases is one of the most important negative prognostic factors in upper gastrointestinal carcinomas. Tumour regression similar to that in primary tumours can be observed in LN metastases after neoadjuvant therapy. We evaluated the prognostic impact of histological regression in LNs in 480 adenocarcinomas of the stomach and gastro‐oesophageal junction after neoadjuvant chemotherapy. Regressive changes in LNs (nodular and/or hyaline fibrosis, sheets of foamy histiocytes or acellular mucin) were assessed by histology. In total, regressive changes were observed in 128 of 480 patients. LNs were categorised according to the absence or presence of both residual tumour and regressive changes (LN−/+ and Reg−/+). 139 cases were LN−/Reg−, 28 cases without viable LN metastases revealed regressive changes (LN−/Reg+), 100 of 313 cases with LN metastases showed regressive changes (LN+/Reg+), and 213 of 313 metastatic LN had no signs of regression (LN+/Reg−). Overall, LN/Reg categorisation correlated with overall survival with the best prognosis for LN−/Reg− and the worst prognosis for LN+/Reg− (p < 0.001). LN−/Reg+ cases had a nearly significant better outcome than LN+/Reg+ (p = 0.054) and the latter had a significantly better prognosis than LN+/Reg− (p = 0.01). The LN/Reg categorisation was also an independent prognostic factor in multivariate analysis (HR = 1.23; 95% CI 1.1–1.38; p < 0.001). We conclude that the presence of regressive changes after neoadjuvant treatment in LNs and LN metastases of gastric and gastro‐oesophageal junction cancers is a relevant prognostic factor.
Combined effects of carotid plaques and hypertension on the risk of cardiovascular disease and all‐cause mortality
Authors: Li Wen , Zhao Jianqiu , Song Lu , Chen Shuohua , Liu Xuemei , Wu Shouling 
Published: May 2020

AbstractBackgroundBoth hypertension and atherosclerotic plaques are risk factors for cardiovascular disease (CVD).HypothesisThis study aimed to investigate whether the combined effects of carotid plaques and hypertension increase the risks of CVD and all‐cause mortality.MethodsPatients from the stroke and elderly cohorts of the Kailuan study in China who completed a carotid sonography examination were included in the study. Participants in both cohorts underwent physical examinations between 2010 and 2011 and were divided into four groups: no carotid plaques with normal blood pressure (n = 2227), hypertension only (n = 1290), carotid plaques only (n = 1128), and hypertension with carotid plaques (n = 1862). The outcomes included the first occurrence of CVD and all‐cause mortality.ResultsAmong the 6507 participants (mean age, 58.1 ± 11.8 years, 61% males), 157 cardiovascular events, and 210 deaths occurred after average follow‐ups of 4.5 and 4.9 years, respectively. After adjusting for covariates, carotid plaques only and hypertension with carotid plaques were associated with excess risk (hazard ratio [HR]; confidence interval [CI]) for the first occurrence of CVD (HR = 1.85; 95% CI, 1.01‐3.44; and HR = 2.97; 95% CI, 1.66‐5.29, respectively), cerebral infarction (HR = 2.66; 95% CI, 1.16‐6.15; and HR = 4.15; 95% CI, 1.87‐9.19, respectively), and all‐cause mortality (HR = 1.96; 95% CI, 1.16‐3.31; and HR = 1.85; 95% CI, 1.09‐3.13, respectively).ConclusionsThe combination of hypertension and atherosclerotic plaques may increase the risk of CVD events and all‐cause mortality, especially cerebral infarction, compared with participants without those factors.
Dependency of the Dimethyldihydropyrene Photochromic Properties on the Number of Pyridinium Electron‐Withdrawing Groups
Authors: Lognon Elise , Heitz Marie‐Catherine , Bakkar Assil , Cobo Saioa , Loiseau Frédérique , Saint‐Aman Eric , Royal Guy , Boggio‐Pasqua Martial 
Published: May 2020

AbstractPhotochromic dimethyldihydropyrenes substituted with electron‐withdrawing pyridinium groups have shown an increase of photo‐induced ring‐opening efficiency and a light sensitivity that is red shifted relative to the unsubstituted compound. However, a recently synthesized tetrapyridinium derivative showed a considerable decrease of the photo‐isomerization quantum yield relative to the monopyridinium and bispyridinium derivatives. We provide a rationale for this unexpected photochemical behavior based on the comparative theoretical investigations of the relevant excited states of these systems. In particular, we found that the nature and order of the lowest two excited states depend on the number of pyridinium groups and on the symmetry of the system. While the lowest S1 excited state is photo‐active in the monopyridinium and bispyridinium derivatives, the photo‐isomerizing state is S2 in the reference unsubstituted compound and both S1 and S2 lead to isomerization in the tetrapyridinium derivative, albeit with a low efficiency. In the latter derivative, the photo‐isomerization is hindered by the particular S1/S2 conical intersection topology.
The Challenge of Distinguishing Cell–Cell Complexes from Singlet Cells in Non‐Imaging Flow Cytometry and Single‐Cell Sorting
Authors: Burel Julie G. , Pomaznoy Mikhail , Lindestam Arlehamn Cecilia S. , Seumois Gregory , Vijayanand Pandurangan , Sette Alessandro , Peters Bjoern 
Published: May 2020

AbstractOur recent work has highlighted that care needs to be taken when interpreting single cell data originating from flow cytometry acquisition or cell sorting: We found that doublets of T cells bound to other immune cells are often present in the live singlet gate of human peripheral blood samples acquired by flow cytometry. This hidden “contamination” generates atypical gene signatures of mixed cell lineage in what is assumed to be single cells, which can lead to data misinterpretation, such as the description of novel immune cell types. Here, based on the example of T cell–monocyte complexes, we identify experimental and data analysis strategies to help distinguishing between singlets and cell–cell complexes in non‐imaging flow cytometry and single‐cell sorting. We found robust molecular signatures in both T cell–monocyte and T cell–B cell complexes that can distinguish them from singlets at both protein and mRNA levels. Imaging flow cytometry with appropriate gating strategy (matching the one used in cell sorting) and direct microscopy imaging after cell sorting were the two methods of choice to detect the presence of cell–cell complexes in suspicious dual‐expressing cells. We finally applied this knowledge to highlight the likely presence of T cell–B cell complexes in a recently published dataset describing a novel cell population with mixed T cell and B cell lineage properties. © 2020 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
Performance of zero cross correlation resultant weight spectral amplitude codes in lower Earth orbit‐based optical wireless channel system
Authors: Kaur Rupinder , Kaler Rajinder Singh 
Published: May 2020

SummaryA consolidated performance investigation and design of newly constructed zero cross correlation resultant weight (ZCCRW) code is presented without mapping over optical wireless channel (OWC) in lower Earth orbit (LEO). Multiple access interference (MAI) is suppressed by incorporating proposed 1‐D code at 10 Gbps with an algorithm. A further state of the art comparison of diverse optical code division multiple access (OCDMA) codes such as multi diagonal codes and diagonal double weight codes is accomplished with proposed code in terms of root mean square (RMS) jitter, extinction ratio, MAI, quality factor (QF), and bit error rate (BER) at different linewidths, chip sizes, link lengths, and active users. It is perceived that for ZCCRW code, QF obtained is 16.5 for chip size (0.1 ns), and at 4000 km, BER 10‐9 is achieved using the forward error correction (FEC) technique. OWC system in LEO with lasers in spectral amplitude code (SAC) OCDMA is proposed for the first time as per the author's best knowledge.
Left bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing
Authors: Li Xiaofei , Qiu Chunguang , Xie Ruiqin , Ma Wentao , Wang Zhao , Li Hui , Wang Hao , Hua Wei , Zhang Shu , Yao Yan , Fan Xiaohan 
Published: May 2020

AbstractAimsThis multicentre observational study aimed to prospectively assess the efficacy of left bundle branch area pacing (LBBAP) in heart failure patients with left bundle branch block (LBBB) and compare the 6‐month outcomes between LBBAP and biventricular pacing (BVP).Methods and resultsConsecutive patients with LBBB and left ventricular ejection fraction (LVEF) ≤ 35% were prospectively recruited if they had undergone LBBAP as a primary or rescue strategy from three separate centres from March to December 2018. Patients who received BVP in 2018 were retrospectively selected by using 2 to 1 propensity score matching to minimize bias. Implant characteristics and echocardiographic parameters were assessed during the 6‐month follow‐up. LBBAP procedure succeeded in 81.1% (30/37) of patients, with selective LBBAP in 10 patients, and 3 of 20 patients combined non‐selective LBBAP and LV lead pacing for further QRS narrowing. LBBAP resulted in significant QRS narrowing (from 178.2 ± 18.8 to 121.8 ± 10.8 ms, P < 0.001, paced QRS duration ≤ 130 ms in 27 patients) and improved LVEF (from 28.8 ± 4.5% to 44.3 ± 8.7%, P < 0.001) during the 6‐month follow‐up. The comparison between 27 patients with LBBAP alone and 54 of 130 matching patients with BVP showed that LBBAP delivered a greater reduction in the QRSd (58.0 vs. 12.5 ms, P < 0.001), a greater increase in LVEF (15.6% vs. 7.0%, P < 0.001), and greater echocardiographic (88.9% vs. 66.7%, P = 0.035) and super response (44.4% vs. 16.7%, P = 0.007) to cardiac resynchronization therapy.ConclusionsLBBAP could deliver cardiac resynchronization therapy in most patients with heart failure and LBBB, and might be a promising alternative resynchronization approach to BVP.
Probing the electrical double layer by operando X‐ray photoelectron spectroscopy through a graphene‐carbon nanotube composite window
Authors: Wang Peng , Li Yunfeng , Wang Luning , Kłos Jacek , Peng Zhiwei , Kim Nam , Bluhm Hendrik , Gaskell Karen , Liu Ping , Lee Sang Bok , Eichhorn Bryan W. , Wang YuHuang 
Published: May 2020

AbstractThe electrical double layer is known to spontaneously form at the electrode‐electrolyte interface, impacting many important chemical and physical processes as well as applications including electrocatalysis, electroorganic synthesis, nanomaterial preparation, energy storage, and even emulsion stabilization. However, it has been challenging to study this fundamental phenomenon at the molecular level because the electrical double layer is deeply “buried” by the bulk electrolyte solution. Here, we report a quantitative probing of the electrical double layer of ionic liquids from the solid side of a photoelectron‐transparent graphene‐carbon nanotube hybrid membrane electrode using X‐ray photoelectron spectroscopy. The membrane window is ultrathin (1‐1.5 nm), large (~1 cm2), and robust, enabling a tight seal of the electrolyte and quantitative measurement with excellent photoelectron signals. By operando monitoring the population changes of cations and anions in response to the applied electrical potentials, we experimentally resolve the chemical structure and dynamics of the electrical double layer, which corroborate results from molecular dynamics simulations.image
Research on the quality changes of grass carp during brine salting
Authors: Yang Wenxian , Shi Wenzheng , Qu Yinghong , Wang Zhihe , Shen Siyuan , Tu Ludan , Huang Haiyuan , Wu Han 
Published: May 2020

AbstractThe research on the quality changes of grass carp during brine salting with 6%, 8%, and 10% salt additions was evaluated by chemical and physical indicators, as well as a sensory assessment and microbiological analysis. The NaCl content was proportional to salt addition and salting time. The increase of salt addition could lead to the increase of hardness and chewiness in which change trends were contrary to the pH within 24 hr. All K values were less than 10% during brine salting. The effect of 8% salt additions on free amino acids was relatively smaller. Higher levels of salt additions could inhibit bacterial growth. Combined with sensory assessment, equivalent umami concentration (EUC), and taste activity value (TAV) to analysis comprehensively, it was suggested that grass carp meat should be eaten at 4–8 hr of brine salting with 8% salt additions or processed for the next step, in which the grass carp meat had a better taste and quality.
Electrochemical Study of the Versatility of a Solid Cell Working both as Fuel Cell and Electrolysis Modes
Authors: Pichot E. , Olivon M. , Perraud A. , Joubert O. , Le Gal La Salle A. 
Published: May 2020

AbstractA Ni/Yttria‐stabilized zirconia (YSZ) cell with a (La0.60Sr0.40)0.95Co0.20Fe0.80O3–δ cathode is tested both in fuel cell and electrolysis modes. In fuel cell mode under dry air and wet H2, the cell is operated between the open circuit voltage (OCV) and 0.4 V and reaches 330 mW cm−2 at 850 °C for 157 mL min−1 H2 supply. The influence of temperature and air or hydrogen flow rate is studied, and impedance measurements show that below 0.8 V the electrolyte becomes the more resistive part of the cell. Nevertheless, fuel utilization yields are higher under oxygen or hydrogen depletion. If it is possible at 750 °C to work at low voltage during several hours in the entire voltage range, the voltage decrease must be limited at 850 °C. The cell can also be operated under wet air. The same cell can be operated in electrolysis mode, and a power density of 340 mW cm−2 can be obtained at 0.3 V/OCV under 100 mL min−1 wet (3% H2O) 5% H2–95% Ar mixture on the fuel side and dry or wet 100 mL min−1 air flow on the air side. Nevertheless, bubbling air providing the air electrode in saltwater has an irreversible detrimental effect on the cell.
Between a rock and a hard place: A critique of economic upgrading in global value chains
Authors: Dindial Miguel , Clegg Jeremy , Voss Hinrich 
Published: May 2020

AbstractResearch SummaryResearchers have tried to understand how insertion into global value chains (GVCs) can lead to economic upgrading for the developing country firms (DCFs) involved. Many of these studies operationalize upgrading as a DCF's movement into higher value‐added activities, where the creation and appropriation of value‐added are assumed to be symbiotic. In doing so, they divorce economic upgrading from its effect on interfirm bargaining power. We address this core assumption by introducing insights from theories on power‐dependence relations. We argue that pursuing an economic upgrading trajectory can be positioned a necessary but insufficient condition for DCF value‐added appropriation. In so doing, we theoretically explicate the conditions under which an economic upgrading trajectory is likely to result in DCF value‐added capture.Managerial SummaryThe fragmentation and dispersion of the multinational enterprises' (MNE) value‐adding activities allows DCFs to insert themselves in the MNEs' value chain. Within both academic and policy spheres, DCFs are encouraged to participate in GVCs as it allows for knowledge and resource transfers from the MNE (upgrading opportunities). In this paper, we offer a critique on this notion of economic upgrading. We argue that researchers have focused on the benefits that new or improved value chain activities can bring, but have largely ignored how these benefits are shared between the chain participants OR members. We address this assumption by introducing power‐dependence and bargaining power to explicate the conditions under which an economic upgrading trajectory can positively influence the DCF's value‐added appropriation.
Resting state functional network switching rate is differently altered in bipolar disorder and major depressive disorder
Authors: Han Shaoqiang , Cui Qian , Wang Xiao , Li Liang , Li Di , He Zongling , Guo Xiaonan , Fan Yun‐Shuang , Guo Jing , Sheng Wei , Lu Fengmei , Chen Huafu 
Published: May 2020

AbstractThe clinical misdiagnosis ratio of bipolar disorder (BD) patients to major depressive disorder (MDD) patients is high. Recent findings hypothesize that the ability to flexibly recruit functional neural networks is differently altered in BD and MDD patients. This study aimed to explore distinct aberrance of network flexibility during dynamic networks configuration in BD and MDD patients. Resting state functional magnetic resonance imaging of 40 BD patients, 61 MDD patients, and 61 matched healthy controls were recruited. Dynamic functional connectivity matrices for each subject were constructed with a sliding window method. Then, network switching rate of each node was calculated and compared among the three groups. BD and MDD patients shared decreased network switching rate of regions including left precuneus, bilateral parahippocampal gyrus, and bilateral dorsal medial prefrontal cortex. Apart from these regions, MDD patients presented specially decreased network switching rate in the bilateral anterior insula, left amygdala, and left striatum. Taken together, BD and MDD patients shared decreased network switching rate of key hubs in default mode network and MDD patients presented specially decreased switching rate in salience network and striatum. We found shared and distinct aberrance of network flexibility which revealed altered adaptive functions during dynamic networks configuration of BD and MDD.
Modified technique of submandibular gland transfer followed by intensity modulated radiotherapy to reduce xerostomia in head and neck cancer patients
Authors: Chang Chia‐Fan , El‐Sayed Ivan H. , George Jonathan R. , Heaton Chase M. , Ryan William R. , Susko Matt S. , Yom Sue S. , Ha Patrick K. 
Published: May 2020

AbstractBackgroundXerostomia is one of the most common long‐term adverse effects of radiotherapy for head and neck cancer patients. Contralateral submandibular gland transfer (SMG‐T) before radiotherapy was shown to reduce xerostomia compared to pilocarpine. We sought to evaluate a modification of this surgery preserving the ipsilateral facial artery and vein to simplify the SMG‐T.MethodsEighteen patients planned for head and neck intensity modulated radiotherapy to both necks were reviewed. Surgical complications were recorded. The grade of xerostomia was assessed after treatment completion.ResultsThere were no minor or major complications resulting from the modified SMG‐T. At 24.5‐months follow up, the incidence of post‐treatment moderate to severe xerostomia was 16.7%. No locoregional recurrence occurred. Only one patient had distant solitary lung metastasis.ConclusionThe modified SMG‐T technique is a practical and effective method to reduce the dose of radiation to the contralateral SMG and limit post‐treatment xerostomia.
Paid surrogacy abroad does not violate public policy: UK Supreme Court
Authors: Dickens Bernard M. 
Published: May 2020

AbstractIn April 2020, the United Kingdom Supreme Court upheld compensation for a woman whose negligent medical care had left her dependent on surrogate motherhood (SM) to have a family, even though SM might be by lawful commercial services in California, USA. Paid SM is criminal in the UK. Altruistic SM arrangements are legal, but unenforceable. The trial judge felt bound by precedent to disallow compensation for lawful commercial SM abroad, as contrary to public policy. The Court of Appeal reversed this ruling, since public policy is not immutable, and had changed. The Supreme Court agreed, acknowledging an evolution in popular attitudes concerning what a family is, and how it might be formed. Government policy was observed to accommodate SM in suitable cases. Movement was perceived towards legislative reform, and judicial recognition of paid SM arrangements abroad that are not exploitative or abusive of surrogates, commissioning parents, or resulting children was considered appropriate.
A paternal t(6;22)(q25.3;p12) leading to a deleted and satellited der(6) in a short‐lived infant
Authors: Domínguez María Guadalupe , Rivera Horacio , Dávalos‐Pulido Rosa María , Dávalos‐Rodríguez Ingrid Patricia 
Published: May 2020

AbstractBackgroundNon‐acrocentric satellited chromosomes mostly result from familial balanced insertions or translocations with p12 or p13 of any acrocentric. Although all non‐acrocentrics have been involved, only 12 instances of chromosome 6 involvement are known.Case presentationA female infant exhibited clinical features typical of 6qter deletions and also generalized hypertrichosis and synophrys, traits seldom reported in patients with similar imbalances or haploinsufficiency of ARID1B located in 6q25.3. She had a paternal derivative satellited 6q of a t(6;22)(q25.3;p12)pat entailing a 6q terminal deletion, karyotype 46,XX,der(6)t(6;22)(q25.3;p12)pat [16].ish del 6q subtel–.ConclusionMale and female carriers of reciprocal translocations or insertions between chromosome 6 and the short arm of any acrocentric have few unbalanced offspring mostly by adjacent‐1 segregation. In addition, spontaneous abortions or male infertility was present in 7/13 instances of satellited chromosome 6.