bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design for Relations
Authors: Stamatopoulou Athina 
Published: December 2020

The city, composed of heterogeneous relations, is an open complex system, beyond its physicality. Questioning analysis and design, a work-in-progress methodology of a generative mapping negotiating different kinds of design logics is presented. The methodology is composed of (1) data gathering; (2) investigating relations among data; and (3) testing with two cases elicited from Athens Center public space. The focus is on how such a relational-thinking methodology cultivates design logics through design­ing by analyzing; designing by defining frame(s); designing the program; designing as an interventional strategy in/through interdependencies; designing by intervening with territorial forces; and employing intra-parametric strategies. By enforcing emergence and management of complexities in diverse fields of potential application, the methodology negotiates the limits and the ways of design.

Keywords:
Systemic urban design, relational design, relational territorialities, relationally generated complexity; design methodology; open method; diagrammatic mapping
Integrative Systems of Production
Authors: Snow Tom 
Published: December 2020

Different branches of design are shifting from a primary focus on artefacts as ends to concentrating on means (e.g. forms of production), with ends encompassing larger societal goals. Concurrently, humanity is facing an increasingly carbon-and-freshwater-constrained world, combined with escalating realities of climate change and ecosystem degradation; thus, our means of production must evolve. An integrative framework and model has been developed to support designers (and other stakeholders) working on regenerative systems of production. The model integrates synergistic, circular, cascading and aggregate efficiency design systems based on ecosystem concepts, as well as regenerative agriculture, the bioeconomy and the (technical) circular economy. With this integrative approach, stakeholders may develop more productive, regenerative synergies and hybrid activities that produce zero waste. The model can be applied at the micro-, meso- and macro-scales.

Keywords: Systemic design, ecological design, biomimetics, circular economy, regenerative agriculture.
Outcomes with different administration schedules of bortezomib in bortezomib, lenalidomide and dexamethasone (VRd) as first‐line therapy in multiple myeloma
Authors: Cook Joselle , Johnson Isla , Higgins Alexandra , Sidana Surbhi , Warsame Rahma , Gonsalves Wilson , Gertz Morie A. , Buadi Francis , Lacy Martha , Kapoor Prashant , Dispenzieri Angela , Kourelis Taxiarchis , Dingli David , Fonder Amie , Hayman Suzanne , Hobbs Miriam , Hwa Yi Lisa , Kyle Robert , Leung Nelson , Go Ronald , Rajkumar Vincent S. , Kumar Shaji 
Published: December 2020

AbstractInduction therapy for multiple myeloma with bortezomib (Velcade), lenalidomide (Revlimid), and dexamethasone (d) (VRd) was traditionally administered as bortezomib given twice weekly on a 3 week cycle. A modified schedule of weekly bortezomib has been adopted over time to decrease treatment burden for patients and reduce treatment‐emergent neuropathy. This study evaluates the response rates and outcomes with different schedules of bortezomib in VRd administered for first‐line treatment for patients with newly diagnosed MM (NDMM). We retrospectively analyzed patients treated with upfront VRd from June 30th 2008 to December 31st 2018, for variations of bortezomib administration. Five hundred and fifty‐five (555) NDMM patients met inclusion criteria; median age 63 years and 61% men. Bortezomib was administered twice weekly every 21 days in 43%, once weekly every 21 days in 41% and once weekly every 28 days in 16%. Though peripheral sensory neuropathy was more frequent with twice weekly dosing (P = .002), this group achieved shorter time to best response (P = .01). Weekly every 21‐day treatment saw higher VGPR or better rates (P = .02). However, with median follow up time of 37 months (IQR 22–56), we found no difference in PFS or OS among the groups. While small differences in response rates were found among the varying administration schedules of bortezomib administration, there was no significant effect on PFS or OS. Given that VRd remains a first line standard of care option for newly diagnosed MM, in the absence of a large trial comparing bortezomib dosing schedule modifications, these results are helpful in supporting current practices of once weekly administration.
Serotonin‐release assay‐positive but platelet factor 4‐dependent enzyme‐immunoassay negative: HIT or not HIT?
Authors: Warkentin Theodore E. , Smythe Maureen A. , Ali Mona A. , Aslam Naveed , Sheppard Jo‐Ann I. , Smith James W. , Moore Jane C. , Arnold Donald M. , Nazy Ishac 
Published: December 2020

AbstractIgG‐specific and polyspecific PF4‐dependent enzyme‐immunoassays (EIAs) have exceptionally high sensitivity (≥99%) for diagnosis of heparin‐induced thrombocytopenia (HIT), a drug reaction caused by platelet‐activating antibodies detectable by serotonin‐release assay (SRA). The IgG‐specific EIAs are recommended for screening, as their high sensitivity is accompanied by relatively high specificity vis‐à‐vis polyspecific EIAs. We investigated the frequency of SRA‐positive/EIA‐negative (SRA+/EIA−) HIT, prompted by referral to our reference HIT laboratory of serial blood samples from a patient (“index case”) with false‐negative IgG‐specific EIAs. Despite initial clinical suspicion for HIT, repeat negative IgG‐specific EIAs prompted heparin resumption, which triggered recurrent thrombocytopenia and near‐fatal cardiac arrest, indicating likely post‐heparin HIT‐associated anaphylactoid reaction. Further investigations revealed a strong‐positive SRA, whether performed with heparin alone, PF4 alone, or PF4/heparin, with inhibition by Fc receptor‐blocking monoclonal antibody (indicating IgG‐mediated platelet activation); however, five different IgG‐specific immunoassays yielded primarily negative (or weak‐positive) results. To investigate the frequency of SRA+/EIA− HIT, we reviewed the laboratory and clinical features of patients with this serological profile during a 6‐year period in which our reference laboratory investigated for HIT using both SRA and IgG‐specific EIA. Although ~0.2% of 8546 patients had an SRA+/EIA− profile, further review of 15 such cases indicated clerical/laboratory misclassification or false‐positive SRA in all, with no SRA+/EIA− HIT case identified. We conclude that while SRA+/EIA− HIT is possible—as shown by our index case—this clinical picture is exceptionally uncommon. Moreover, the requirement for a positive EIA is a useful quality control maneuver that reduces risk of reporting a false‐positive SRA result.
Electron beam irradiation modified electrospun polyvinylidene fluoride/polyacrylonitrile fibrous separators for safe lithium‐ion batteries
Authors: Jia Shaojin , Huang Kaili , Long Jiating , Yang Shaohua , Liang Yuhao , Yang Na , Xiao Jun 
Published: December 2020

AbstractThis work aims to obtain more hydrophilic and thermal stable electrospun fibrous membranes for lithium‐ion battery separators. For this purpose, the polyvinylidene fluoride/polyacrylonitrile (PVDF/PAN) separators are fabricated via electrospinning and modified by an electron beam with different doses. These preparation processes are simple, fast, and environmentally friendly. As the same time, the physical and electrochemical properties of these separators are investigated in detail. The results indicated that all the irradiated PVDF/PAN (the mass ratio of PVDF and PAN is 1:1) separators can maintain a complete structure till 170°C due to their cross‐linking structure. Besides, the 150‐kGy‐irradiated PVDF/PAN separator exhibits high porosity (82%), excellent electrolyte absorption (497%), and high ionic conductivity (3.19 mS cm−1). As a consequence, the cells with 150‐kGy‐irradiated PVDF/PAN separators show better the C‐rate performance and cycling stability than those of the cells with polypropylene separators and nonirradiated PVDF/PAN separators.
Newly diagnosed seizures assessed at two established first seizure clinics: Clinic characteristics, investigations, and findings over 11 years
Authors: McIntosh Anne M. , Tan K. Meng , Hakami Tahir M. , Newton Mark R. , Carney Patrick W. , Yang Mengjiazhi , Saya Sibel , Marco David J. T. , Perucca Piero , Kwan Patrick , O’Brien Terence J. , Berkovic Samuel F. 
Published: December 2020

AbstractObjective‘First seizure’ clinics (FSCs) aim to achieve early expert assessment for individuals with possible new‐onset epilepsy. These clinics also have substantial potential for research into epilepsy evolution, outcomes, and costs. However, a paucity of FSCs details has implications for interpretation and utilization of this research.MethodsWe reviewed investigation findings over 11 years (2000‐2010) from two established independent FSCs at Austin Health (AH) and Royal Melbourne Hospital (RMH), Australia. These adult clinics are in major public hospitals and operate with similar levels of expertise. Organizational differences include screening and dedicated administration at AH. Included were N = 1555 patients diagnosed with new‐onset unprovoked seizures/epilepsy (AH n = 901, RMH n = 654). Protocol‐driven interviews and investigations had been recorded prospectively and were extracted from medical records for study.ResultsMedian patient age was 37 (IQR 26‐52, range 18‐94) years (AH 34 vs RMH 42 years; P < .001). Eighty‐six percent of patients attended FSC within three weeks postindex seizure (median AH 12 vs RMH 25 days; P < .01). By their first appointment, 42% had experienced ≥2 seizures. An EEG was obtained within three weeks postindex seizure in 73% of patients, demonstrating epileptiform discharges in 25% (AH 33% vs RMH 15%). Seventy‐six percent of patients had an MRI within 6 weeks. Of those with imaging (n = 1500), 19% had potentially epileptogenic abnormalities (RMH 28% vs AH 12%; P < .01). At both sites, changes due to previous stroke/hemorrhage were the commonest lesions, followed by traumatic brain injury. ≥WHO level 1 brain tumors diagnosed at presentation comprised a very small proportion (<1%) at each clinic. At both sites, epilepsy type could be determined in 60% of patients; RMH had more focal and AH more generalized epilepsy diagnoses.SignificanceDifferences between the clinics’ administrative and screening practices may contribute to differences in investigation findings. Insight into these differences will facilitate interpretation and utilization, and planning of future research.
Computational prediction on the catalytic activity of heterobimetallic complex featuring MMˊ triple bond in acetylene cyclotrimerization: Mechanistic study
Authors: Zhang Na , Mi Jinhui , Huo Suhong , Meng Lingpeng , Li Xiaoyan 
Published: December 2020

AbstractA detailed reaction mechanism of acetylene cyclotrimerization catalyzed by V(iPrNPMe2)3Fe‐PMe3(denote as CAT), a heterobimetallic complex featuring V‐Fe triple bond, was computationally investigated using density functional theory. The calculated results show that the first acetylene firstly attaches to the V atom of CAT to get a four‐membered ring structure through [2 + 2] cycloaddition reaction. For the second acetylene addition, there are two cyclotrimerization mechanisms, outer sphere mechanism and inner mechanism. The inner sphere reaction pathway is the main reaction pathway. By replacing the V with Nb and Ta, Fe with Ru and Os, a series of new catalysts are screened computationally. The calculated results show that, all of the nine heterobimetallic complexes show high activity at mild condition. The energy barrier of the rate determining step is related to the natural population analysis (NPA) charge of Mˊ and the Wiberg bond index (WBI) of M‐Mˊ bond. The more negative NPA charge of Mˊ and the smaller WBI of M‐Mˊ bond, the lower energy barrier is.
Investigation of the Arctic Sea ice volume from 2002 to 2018 using multi‐source data
Authors: Li Mengmeng , Ke Chang‐Qing , Shen Xiaoyi , Cheng Bin , Li Haili 
Published: December 2020

AbstractThe Arctic sea ice volume (SIV) was investigated by applying sea ice concentration (SIC) and multi‐source sea ice thickness (SIT) products from the Pan‐Arctic Ice‐Ocean Modelling and Assimilation System (PIOMAS), Envisat and CryoSat‐2 (CS‐2) products. The SIV was estimated during the sea ice growth season (October–April) from October 2002 to December 2018. During the Envisat period (October 2002–April 2010), negative SIV trends were estimated by a hybrid Envisat and PIOMAS SIT dataset (defined as Envi‐PIO); the declining trends for both the maximum/minimum SIV were 360 and 177 km3⋅year−1, respectively; similar SIV trends were obtained by applying only the PIOMAS SIT data. During the CS‐2 period (October 2010–December 2018), no clear trends in the SIV were estimated by either CS‐2 or PIOMAS, except for clear increases in the SIV in northern Greenland and the Canadian Arctic Archipelago (CAA) using the CS‐2 SIT data. The age of sea ice plays an important role in SIV variability. For example, the SIV trend was found to be similar to the multi‐year ice trend between 2003 and 2007. The correlation coefficients between the monthly mean SIV and surface air temperature (SAT) and sea surface temperature (SST) were −0.60 and −0.82, respectively. The decreasing trend in the SIV during the Envisat period was influenced by the increase in the annual maximum SST and minimum SAT. The significant increase in the SIV in northern Greenland and the CAA during the CS‐2 period was related to ice deformation.
Temperature and Photo Dual‐Stimuli Responsive Block Copolymer Self‐Assembly Micelles for Cellular Controlled Drug Release
Authors: Zhou Zi‐Hao , Zhang Jian‐Guo , Chen Qing , Luo Yan‐Ling , Xu Feng , Chen Ya‐Shao 
Published: December 2020

AbstractTo well adapt to the complicated physiological environments, it is necessary to engineer dual‐ and/or multi‐stimuli responsive drug carriers for more effective drug release. For this, a novel temperature responsive lateral chain photosensitive block copolymer, poly[(N‐isopropylacrylamide‐co‐N,N‐dimethylacrylamide) ‐block‐propyleneacylalkyl‐4‐azobenzoate] (P(NIPAM‐co‐DMAA)‐b‐PAzoHPA), is synthesized by atom transfer radical polymerization. The structure is characterized by 1H nuclear magnetic resonance spectrometry and laser light scattering gel chromatography system. The self‐assembly behavior, morphology, and sizes of micelles are investigated by fluorescence spectroscopy, transmission electron microscope, and laser particle analyzer. Dual responsiveness to light and temperature is explored by ultraviolet–visible absorption spectroscopy. The results show that the copolymer micelles take on apparent light and temperature dual responsiveness, and its lower critical solution temperature (LCST) is above 37 °C, and changes with the trans‐/cis‐ isomerization of azobenzene structure under UV irradiation. The blank copolymers are nontoxic, whereas the paclitaxel (PTX)‐loaded counterparts possessed comparable anticancer activities to free PTX, with entrapment efficiency of 83.7%. The PTX release from the PTX‐loaded micelles can be mediated by changing temperature and/or light stimuli. The developed block copolymers can potentially be used for cancer therapy as drug controlled release carriers.
Operational statistical postprocessing of temperature ensemble forecasts with station‐specific predictors
Authors: Ylinen Kaisa , Räty Olle , Laine Marko 
Published: December 2020

AbstractA proper account for forecast uncertainty is crucial in operational weather services and weather‐related decision‐making. Ensemble forecasts provide such information. However, they may be biased and tend to be under‐dispersive. Therefore, ensemble forecasts need to be post‐processed before using them in operational weather products. The present study post‐processes the European Centre for Medium‐Range Weather Forecasts (ECMWF) ensemble prediction system temperature forecasts over Europe with lead times up to 240 hr using the statistical calibration method that is currently implemented in operational workflow at the Finnish Meteorological Institute (FMI). The calibration coefficients are estimated simultaneously for all stations using a 30 day rolling training period. Station‐specific characteristic are accounted for by using elevation, latitude and land–sea mask as additional predictors in the calibration. On average the calibration improved the ensemble spread over Europe, although the improvements varied between different verification months. In March, the calibration improved ensemble forecasts the most, while in January the performance depended strongly on location. A comparison between three versions with different sets of station‐specific predictors in calibration showed that elevation was the most important predictor, while latitude and land–sea mask improved the forecasts mostly with shorter lead times. The calibration for the Finnish stations was also tested using three different size training domains in order to find the optimal training area. The results showed that smaller training domains had a significant effect on calibration performance only at lead times up to a few days. With longer lead times, the calibrated forecasts were better when all available stations were included.
Saving cognitive outcome data in Alzheimer's disease clinical trials during the COVID‐19 pandemic: Commentary on the virtual administration of the ADAS‐Cog
Authors: Schwab Nadine A. , DesRuisseaux Libby A. , Weinberg Marc S. , Arnold Steven E. 
Published: December 2020

AbstractElderly participants in Alzheimer's disease (AD) clinical trials are at high risk of morbidity and mortality with interpersonal exposure to COVID‐19, a situation that is likely to continue for the foreseeable future. Yet, in‐person neuropsychological assessments remain the mainstay primary outcomes for clinical trials seeking prevention and cure for AD. The Alzheimer's Disease Assessment Scale‐Cognitive (ADAS‐Cog) is among the most commonly used cognitive assessment in AD clinical trials, and though currently lacking specific guidelines for virtual administrations, it can be used remotely with appropriate modifications and considerations. Here we propose a novel method of virtual administration of the ADAS‐Cog, which considers workarounds for technological and human limitations imposed when the participant is no longer sitting across from the test administrator.
BCJ, worldsheet quantum algebra and KZ equations
Authors: Fu Chih-Hao , Wang Yihong 
Published: December 2020

Abstract
We exploit the correspondence between twisted homology and quantum group to construct an algebra explanation of the open string kinematic numerator. In this setting the representation depends on string modes, and therefore the cohomology content of the numerator, as well as the location of the punctures. We show that quantum group root system thus identified helps determine the Casimir appears in the Knizhnik-Zamolodchikov connection, which can be used to relate representations associated with different puncture locations.
Hydrodynamics of simply spinning black holes & hydrodynamics for spinning quantum fluids
Authors: Garbiso Markus , Kaminski Matthias 
Published: December 2020

Abstract
We find hydrodynamic behavior in large simply spinning five-dimensional Anti-de Sitter black holes. These are dual to spinning quantum fluids through the AdS/CFT correspondence constructed from string theory. Due to the spatial anisotropy introduced by the angular momentum, hydrodynamic transport coefficients are split into groups longitudinal or transverse to the angular momentum, and aligned or anti-aligned with it. Analytic expressions are provided for the two shear viscosities, the longitudinal momentum diffusion coefficient, two speeds of sound, and two sound attenuation coefficients. Known relations between these coefficients are generalized to include dependence on angular momentum. The shear viscosity to entropy density ratio varies between zero and 1/(4π) depending on the direction of the shear. These results can be applied to heavy ion collisions, in which the most vortical fluid was reported recently. In passing, we show that large simply spinning five-dimensional Myers-Perry black holes are perturbatively stable for all angular momenta below extremality.
The impact of flavour data on global fits of the MFV SMEFT
Authors: Aoude Rafael , Hurth Tobias , Renner Sophie , Shepherd William 
Published: December 2020

Abstract
We investigate the information that can be gained by including flavour data in fits of the Standard Model Effective Field Theory (SMEFT) with the assumption of Minimal Flavour Violation (MFV), allowing — as initial conditions at the high scale — leading terms in spurionic Yukawas only. Starting therefore from a theory with no tree level flavour changing neutral currents at the scale of new physics, we calculate effects in flavour changing processes at one loop, and the resulting constraints on linear combinations of SMEFT coefficients, consistently parameterising the electroweak parameters and the CKM within the SMEFT. By doing a global fit including electroweak, Higgs and low energy precision measurements among others, we show that flavour observables put strong constraints on previously unconstrained operator directions. The addition of flavour data produces four independent constraints at order TeV or above on otherwise flat directions; reducing to three when complete U(3)5 flavour symmetry is assumed. Our findings demonstrate that flavour remains a stringent test for models of new physics, even in the most flavourless scenario.
Reproducibility of tumor budding assessment in pancreatic cancer based on a multicenter interobserver study
Authors: Karamitopoulou Eva , Esposito Irene , Zlobec Inti , Insilla Andrea Cacciato , Wartenberg Martin , Schaeffer David F. , Kalloger Steve , La Rosa Stefano , Sempoux Christine , Ramos Centeno Irene , Lohneis Philipp 
Published: December 2020

AbstractTumor budding has been reported to be an independent prognostic factor in pancreatic ductal adenocarcinoma (PDAC). Its use in daily diagnostics would improve the prognostic stratification of patients. We performed a multicenter interobserver study to test various budding assessment methods for their reproducibility. Two serial sections of 50 resected, treatment-naïve PDACs were stained for Hematoxylin and Eosin (H&E) and pancytokeratin. Tumor budding was scored by independent observers at five participating centers in Switzerland, Germany, and Canada. Pathologists assessed tumor budding on a digital platform comparing H&E with pancytokeratin staining in 10 high-power fields (10HPF) and one HPF hotspot (1HPF). Additionally, tumor budding was assessed in one H&E hotspot at × 20 magnification, as suggested by the International Tumor Budding Consensus Conference (ITBCC). Correlation coefficients for bud counts between centers ranged from r = 0.58648 to r = 0.78641 for H&E and from r = 0.69288 to r = 0.81764 for pancytokeratin. The highest interobserver agreement across all centers was observed for pancytokeratin 10HPFs (ICC = 0.6). ICC values were 0.49, 0.48, 0.41, and 0.4 for H&E in 1HPF hotspot, H&E in 10HPFs, pancytokeratin in 1HPF, and H&E in one hotspot at ×20, respectively (ITBCC method). This interobserver study reveals a range between moderately poor to moderate agreement levels between pathologists for the different tumor budding assessment methods in PDAC. Acceptable levels of agreement were reached with the pancytokeratin 10HPF method, which can thus be recommended for the assessment of tumor budding in PDAC resection specimens. To improve the levels of interobserver agreement, the implementation of machine learning applications should be considered.