bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elaboração e avaliação de um protótipo-aplicativo para cuidador de idosos
Authors: Barbosa de Lira Tatiane , Viana Rocha Francisca Cecília , Landim Almeida Camila Aparecida Pinheiro , Miranda Amorim Fernanda Cláudia , Viana Rocha Lucas Pazolinni 
Published: July 2020

Objetivo: Desarrollar y evaluar un prototipo de dispositivo móvil con directrices para cuidadores de ancianos. Metodología: Investigación metodológica aplicada, de producción tecnológica, descriptiva y exploratoria con abordaje cuantitativo realizado en la institución privada de Educación Superior. Los colaboradores del estudio estuvieron compuestos por un comité de expertos, profesionales de la tecnología de la información (TI) y enfermeras docentes. El estudio fue desarrollado en tres etapas: (I) el análisis de la literatura científica, (II) el desarrollo de la aplicación móvil, (III) la evaluación de la aplicación prototipo. El proyecto fue presentado al Comité de Ética e Investigación, donde se aprobó bajo el número de dictamen 2.723.146. Resultados: Se evaluaron las Características de Calidad a partir de un software: funcionalidad, facilidad de uso, fiabilidad, eficiencia, mantenibilidad y portabilidad. Todo el contenido abordado en la aplicación prototipo fue evaluado por el comité de expertos, donde obtuvo un promedio de 4,6, siendo considerado apto para la validación.Conclusión: La construcción de un prototipo de aplicación para ayudar a los cuidadores de ancianos promueve la posibilidad de resolver una dificultad encontrada de forma simple y dinámica.
Objective: To develop and evaluate a prototype for mobile device with guidelines for caregivers of the elderly.Methodology: Methodological research applied, technological production, descriptive and exploratory, with a quantitative approach performed in Private Higher Education Institution. Study collaborators were composed by a committee of experts, they are professionals of information technology (IT) and Nurse teachers. The study was developed in three stages: (I) Analysis of the scientific literature, (II) development of mobile application, (III) Evaluation of the prototype application. The project was submitted to the Ethics and Research Committee, where it was approved under the number of 2,723,146.Results: Quality characteristics were evaluated from a software: functionality, usability, reliability, efficiency, maintainability and portability. All the content addressed in the prototype application was evaluated by the committee of experts, where he obtained an average of 4.6, being considered suitable for validationConclusion: We found that the construction of a prototype application to assist the caregivers of elderly promotes the possibility of solving a difficulty found in a simple and dynamic.
Estimation of secondary cancer risk after radiotherapy in high‐risk prostate cancer patients with pelvic irradiation
Authors: Haciislamoglu Emel , Gungor Gorkem , Aydin Gokhan , Canyilmaz Emine , Guler Ozan Cem , Zengin Ahmet Yasar , Yenice Kamil Mehmet 
Published: July 2020

AbstractWe aimed to estimate the risk of secondary cancer after radiotherapy (RT) in high‐risk prostate cancer (HRPC) patients with pelvic irradiation. Computed tomography data of five biopsy‐proven HRPC patients were selected for this study. Two different planning target volumes (PTV1 and PTV2) were contoured for each patient. The PTV1 included the prostate, seminal vesicles, and pelvic lymphatics, while the PTV2 included only the prostate and seminal vesicles. The prescribed dose was 54 Gy for the PTV1 with a sequential boost (24 Gy for the PTV2). Intensity‐modulated RT (IMRT) and volumetric modulated arc therapy (VMAT) techniques were used to generate treatment plans with 6 and 10 MV photon energies with the flattening filter (FF) or flattening filter‐free (FFF) irradiation mode. The excess absolute risks (EARs) were calculated and compared for the bladder, rectum, pelvic bone, and soft tissue based on the linear‐exponential, plateau, full mechanistic, and specific mechanistic sarcoma dose‐response model. According to the models, all treatment plans resulted in similar risks of secondary bladder or rectal cancer and pelvic bone or soft tissue sarcoma except for the estimated risk of the bladder according to the full mechanistic model using IMRT(6MV;FF) technique compared with VMAT techniques with FFF options. The overall estimation of EAR indicated that the radiation‐induced cancer risk due to RT in HRPC was lower for bladder than the rectum. EAR values ranged from 1.47 to 5.82 for bladder and 6.36 to 7.94 for rectum, depending on the dose–response models used. The absolute risks of the secondary pelvic bone and soft tissue sarcoma were small for the plans examined. We theoretically predicted the radiation‐induced secondary cancer risk in HRPC patients with pelvic irradiation. Nevertheless, prospective clinical trials, with larger patient cohorts with a long‐term follow‐up, are needed to validate these model predictions.
Responsiveness of outcome measures in myotonic dystrophy type 1
Authors: Knak Kirsten L. , Sheikh Aisha M. , Witting Nanna , Vissing John 
Published: July 2020

AbstractObjectiveAs myotonic dystrophy type 1(DM1) evolves slowly and interventional trials often have a short duration, responsive outcomes in DM1 are needed. The objective of this study was to determine the responsiveness of muscle strength, balance, and functional mobility measurements after a 1‐year follow‐up period in individuals with DM1.MethodsSixty‐three adults with noncongenital DM1 completed the following assessments at baseline and at 1‐year follow‐up: Handheld dynamometry (lower limbs), stationary dynamometry (lower limbs), step test, timed‐up‐and‐go test (TUG), modified clinical test of sensory integration and balance (mCTSIB), feet‐together stance, tandem stance, one‐leg stance, 10‐meter walk test, and sit‐to‐stand test.ResultsChange was captured by stationary dynamometry (proximal flexor and extensor muscles), handheld dynamometry (proximal flexor and distal extensor muscles), TUG, and mCTSIB (P ≤ 0.04). Ceiling or floor effects were shown for most static balance tests.InterpretationOverall, adequate responsiveness was shown for both muscle strength dynamometers, TUG and mCTSIB. These outcomes are therefore likely candidate endpoints for clinical trials lasting 1 year. Most static balance tests are not responsive and not recommended in a heterogeneous DM1 population.
Primary results of a randomized two‐by‐two factorial phase II trial comparing neoadjuvant chemotherapy with two and four courses of cisplatin/S‐1 and docetaxel/cisplatin/S‐1 as neoadjuvant chemotherapy for advanced gastric cancer
Authors: Hayashi Tsutomu , Yoshikawa Takaki , Sakamaki Kentaro , Nishikawa Kazuhiro , Fujitani Kazumasa , Tanabe Kazuaki , Misawa Kazunari , Matsui Takanori , Miki Akira , Nemoto Hiroshi , Fukunaga Tetsu , Kimura Yutaka , Hihara Jun 
Published: July 2020

AbstractAimNeoadjuvant chemotherapy (NAC) is promising to improve the survival of resectable gastric cancer. However, suitable regimen and treatment duration for NAC have not yet been established.MethodsWe conducted a randomized phase II trial to compare two and four courses of neoadjuvant S‐1/cisplatin (SC) and S‐1/cisplatin/docetaxel(DCS) using a two‐by‐two factorial design for locally resectable advanced gastric cancer. Patients with M0 and either T4 or T3 in case of junctional cancer or scirrhous‐type cancer received two or four courses of SC or DCS. Then, patients underwent D2 gastrectomy and adjuvant S‐1 chemotherapy for 1 year. The primary endpoint was 3‐year overall survival. The planned sample size was 120 eligible patients.ResultsBetween October 2011 and September 2014, 132 patients were assigned to CS (n = 66; 33 in 2‐courses and 33 in 4‐courses) and DCS (n = 66; 33 in 2‐courses and 33 in 4‐courses). The 3‐year OS was 58.1% in CS and 60.0% in DCS with hazard ratio of 0.80 (95% CI, 0.48‐1.34), while it was 53.1% in the two courses and 65.0% in the four courses with hazard ratio of 0.72 (95% CI, 0.43‐1.22). In the survival analysis by duration in each regimen, the 3‐year OS was 58.1% for both two and four courses in CS, while it was 48.5% for two courses of DCS and 71.9% for four courses of DCS.ConclusionsConsidering high 3‐year OS, four courses DCS has a value to be tested in a future phase III study to confirm superiority of neoadjuvant chemotherapy for locally advanced gastric cancer.
Improved processability ofPA66‐polyimidecopolymers with different polyimide contents
Authors: Qu Chunyan , Tang Yao , Wang Dezhi , Fan XuPeng , Li Hongfeng , Liu Changwei , Su Kai , Zhao Daoxiang , Jing Jiaqi , Zhang Xiao 
Published: July 2020

AbstractLimitations in the properties of polyamide PA66, such as low glass transition temperature and high water absorptivity, limit its applications. Introduction of amorphous polyimide segments into the PA66 main chain lowers the glass transition temperature and melting temperature and also improves its processability. PA66‐polyimide (PA‐PI) copolymers with different weight ratios of PI are prepared by high temperature and high‐pressure solution polymerization. The degree of crystallization of PA‐PI copolymers decreases with increasing PI content. The melting point decreases from 261°C for PA66 to 223°C for PA‐PI‐4. Dynamic mechanical analysis shows that theTgincreases from 70 to 90°C, and the storage modulus can be well maintained. Rheological studies show that the temperature for processing can reach 70°C. Copolymers with different PI contents show different processing viscosities. In addition, water absorptivity (about 1.8%) and dielectric constant values of PA‐PI and PA6/6T are similar.
Behavior in cheating paradigms is linked to overall approval rates of crowdworkers
Authors: Schild Christoph , Lilleholt Lau , Zettler Ingo 
Published: July 2020

AbstractDishonest and fraudulent behavior poses a serious threat to both individuals and societies. Many studies investigating dishonesty rely on (one of) a few well‐established lab and online cheating paradigms. Quite surprisingly, though, the external validity of these paradigms has only been investigated in a small number of studies, raising the question of whether behavior in these paradigms is related to real‐life dishonesty or, more broadly, socially questionable behavior. Tackling this gap, we link observed behavior in two widely used cheating paradigms to approval rates on two crowdworking platforms (namely, Prolific and Amazon Mechanical Turk) using data from four studies (overall N = 5,183). Results indicate that lower approval rates are associated with higher proportions of dishonest individuals. Importantly, this relation also holds for crowdworkers who exceed commonly used thresholds for study inclusion. The results thus support the external validity of (two widely used) cheating paradigms. Further, the study identifies approval rates as a variable that explains dishonesty on crowdworking platforms.
The role of presence when working with children and young people demonstrating harmful sexual behaviour
Authors: Cranbourne‐Rosser Melody , Campbell Miglena , Pilkington Lesley , Carthy Nikki 
Published: July 2020

AbstractWorking with children and young people (CYP) demonstrating harmful sexual behaviour (HSB) is complex and requires understanding of the dual identity of ‘victim’ and ‘victimiser’. Working with such experiences can impact on therapeutic processes, such as ‘presence’, a phenomenon manifesting from connection and moment‐to‐moment awareness. Research into presence generally focuses on working with adults. This study explored presence when working with CYP demonstrating HSB. Eight practitioners were interviewed focusing on their lived experiences of presence in terms of personal perception, cultivation, and influence on practice and sustainability. Interviews were analysed using interpretative phenomenological analysis, which resulted in two main themes: ‘presence and person’ and ‘presence and place’. Findings suggested that in addition to presence and the therapeutic relationship enhancing each other qualitatively, presence provides a platform of connectivity from which to engage, promotes working from a whole‐person perspective and assigns deeper meaning to the work; cultivation requires opportunities to identify, enhance and embrace the phenomenon in order to promote self‐awareness and utilise presence effectively with others; practitioner well‐being and sustainability requires application of self‐care strategies and robust workplace support; and the development of a safe and productive presence‐informed service requires suitable processes and procedures to be established. These points are considered in terms of implications and future recommendations for practice and policy.
Sublingual emphysema following alveoloplasty: A case report
Authors: Dodge Austin , Kreh Katelyn , Kofina Vrisiis , Rawal Swati Y. 
Published: July 2020

AbstractVarious cases of introduction of air into soft tissues have been reported in the dental literature. Here, we report a rare case of localized sublingual emphysema after alveoloplasty. There was no facial involvement. The patient responded to treatment and recovered uneventfully.
A case of COVID‐19 with the atypical CT finding
Authors: Kurimoto Ryota , Sakurai Kenji , Motoori Ken , Suda Akira 
Published: July 2020

AbstractCOVID‐19 usually demonstrates the specific pattern of chest CT findings (GGO, inverted‐halo sign, etc). However, some COVID‐19 cases show atypical CT findings. Physicians should make comprehensive judgments.
Protein A immunoadsorption combination with immunosuppressive therapy improves neuropsychiatric systemic lupus erythematosus: A case report
Authors: Wen Feng , Wu Xiaoling , Liao Ruyi , Feng Zhonglin , Li Zhilian , Fu Xia , Fu Lei , Li Sijia , Li Zhuo , Li Sheng , Wang Wenjian , Huang Biao , He Chaosheng , Wei Shi , Liang Xinling , Liu Shuangxin 
Published: July 2020

AbstractWe described protein A immunoadsorption combination with immunosuppressive treatment improved rapidly a patient with Neuropsychiatric systemic lupus erythematosus.
Testing for nonlinear genotype × environment interactions
Authors: Yang Rong‐Cai 
Published: July 2020

AbstractThe responses of different genotypes to an environmental gradient are often nonlinear and nonparallel. Current tests for differential genotypic responses are based largely on linear regression models (stability analysis) or on evaluations of all quadruples for crossover interactions (COIs) from a two‐way genotype × environment (G × E) table if the environments are unquantified. The objective of this study was to develop a new statistical analysis for comparing nonlinear genotypic response curves over an environmental gradient. We first conducted an investigation to find the points where the two nonparallel curves intersected. If the intersection points lie within the attainable environmental range, the two nonparallel curves involve COI; if the points lie at the boundaries or outside the attainable range, the nonparallel curves do not involve COI. We then developed statistical tests for comparing a full and a reduced model describing the two nonparallel curves. The tests were used to analyze a wheat (Triticum aestivum L.) germination test (WGT) data under the reciprocal of a linear function and a barley (Hordeum vulgare L.) cultivar trial (BCT) data under Cauchy function. The WGT analysis shows that at least one pair of cultivars involve COI over the temperature gradient, which went undetected by a previous test based on all possible quadruples. The BCT analysis revealed that 56% of 780 possible pairs of 40 genotypes differ significantly from each other, providing more insights into the patterns of complex G × E interactions. Our analysis is therefore a viable alternative to the existing procedures.
Pitfalls during in silico prediction of primer specificity for eDNA surveillance
Authors: So Ken Ying Kin , Fong Jonathan J. , Lam Ivan Pui Yin , Dudgeon David 
Published: July 2020

AbstractWhile high efficiency and cost‐effectiveness are two merits of environmental DNA (eDNA) techniques for detecting aquatic organisms, the difficulty of designing species‐specific primers can result in significant expenditure of time and money. During the in silico stage of primer development, primer specificity is predicted with alignment techniques such as BLAST that is based on the number and position of the primer/nontarget template mismatches. However, we speculate that nonspecific amplification is influenced by additional parameters, which lead to inaccuracies of in silico prediction. We performed in vitro specificity tests for 38 species‐specific primers selected for seven fishes and six turtles, using single‐plex conventional PCR (cPCR). A subset of 12 primer pairs were further tested with SYBR Green‐based or TaqMan‐based single‐plex quantitative PCR (qPCR). We disentangle the relative importance of mismatch properties (types and positions), primer properties (length, GC content, and 3′ end stability), PCR conditions (template concentrations and annealing temperatures), and PCR technique (cPCR, TaqMan‐based, or SYBR Green‐based qPCR) in determining the occurrence of amplifications. We then compared the PCR outcomes with the specificity check under two stringency scenarios based on alignment (i.e., BLAST search). We conducted a total of 679 cPCR and 226 qPCR analyses, with 90% of the reactions tested with nontarget templates. Primer pairs predicted by Primer‐BLAST to be specific rarely showed such specificity during the in vitro testing. BLAST searches correctly predicted the outcomes of around 67% of cPCR and qPCR, but had low sensitivity in detection of nontarget amplification (29–57%). Primer specificity increased significantly with total number of mismatches and annealing temperature, but decreased with higher GC content in the primer sequence. Mismatches that consisted of A‐A, G‐A, and C‐C pairings exerted 56% stronger reduction in nonspecific amplification effects than other mismatches. To conclude, we show that the prediction of primer specificity based only on the number and position of mismatches can be misleading. Our findings can be applied to increase the efficiency of the in silico primer selection process to maintain the relatively high efficiency and cost‐effectiveness of eDNA techniques.
Long‐distance atmospheric moisture dominates water budget in permafrost regions of the Central Qinghai‐Tibet plateau
Authors: Zhu Xiaofan , Wu Tonghua , Hu Guojie , Wang Shengjie , Wu Xiaodong , Li Ren , Wang Weiguo , Wen Amin , Ni Jie , Li Xiangfei , Hao Junming 
Published: July 2020

AbstractPrecipitation plays an important role in permafrost hydrology; it can alter the hydrothermal condition of the active layer and even influence the permafrost aggradation or degradation. Moisture recycling from evaporation and transpiration can greatly contribute to local precipitation in some regions. This study selected four monitoring sites and used an isotope mixing model to investigate local moisture recycling in permafrost regions of the central Qinghai‐Tibet Plateau (QTP). The results showed that the local water vapour flux in the summer and autumn were dominantly influenced by westerlies and the Indian monsoon. Moistures for precipitation in Wudaoliang (WDL) and Fenghuoshan (FHS) mainly came from the western QTP, eastern Tianshan Mountains, western Qilian Mountains, and the surrounding regions. In comparsion, more than half of precipitation at Tanggula (TGL) was mostly sourced from the Indian monsoon. Local moisture recycling ratios at the four sites ranged from 14% ± 3.8% to 31.6% ± 4.8%, and depended on the soil moisture and relative humidity. In particular, the higher soil moisture and relative humidity promoted local moisture recycling, but frozen ground might be a potential influencing factor as well. The moisture recycling ratios of the study area were consistent with the results from both the Qinghai Lake Basin and the Nam Co Basin, but differed from those of the northwestern QTP. This difference may indirectly confirm the great spatial variability in precipitation on the QTP. Moreover, the rising air temperature and ground temperature, increasing precipitation, higher soil moisture, higher vegetation cover, and expanding lakes in the study area may be conductive to enhancing future local moisture recycling by altering ground surface conditions and facilitating the land surface evaporation and plant transpiration.
Application of microcosm experiments for quantifying lateral flow and evapotranspiration on recovering bog ecotypes
Authors: Swenson Michael M. , Regan Shane , Gill Laurence W. 
Published: July 2020

AbstractThe importance of characterizing the ecohydrological interactions in natural, damaged/drained, and restored bogs is underscored by the importance of peatlands to global climate change and the growing need for peatland restoration. An understudied aspect of peatland ecohydrology is how shallow lateral flow impacts local hydrological conditions and water balance, which are critical for peatland restoration success. A novel method is presented using microcosms installed in the field to understand the dynamics of shallow lateral flow. Analysis of the difference in water table fluctuation inside and outside the microcosm experimental areas allowed the water balance to be constrained and the calculation of lateral flow and evapotranspiration. As an initial demonstration of this method, a series of four microcosm experiments were set up in locations with differing ecological quality and land management histories, on a raised bog complex in the midlands of Ireland. The timing and magnitude of the lateral flow differed considerably between locations with differing ecological conditions, indicating that shallow lateral flow is an important determining factor in the ecohydrological trajectory of a recovering bog system. For locations where Sphagnum spp. moss layer was present, a slow continuous net lateral input of water from the upstream catchment area supported the water table during drought periods, which was not observed in locations lacking Sphagnum. Consistent with other studies, evapotranspiration was greater in locations with a Spaghnum moss layer than in locations with a surface of peat soil.
Modified Global Flower Pollination Algorithm‐based image fusion for medical diagnosis using computed tomography and magnetic resonance imaging
Authors: Sumithra M. , Malathi S. 
Published: July 2020

AbstractRecently, the computed tomography (CT) and magnetic resonance imaging (MRI) medical image fusion have turned into a challenging issue in the medical field. The optimal fused image is a significant component to detect the disease easily. In this research, we propose an iterative optimization approach for CT and MRI image fusion. Initially, the CT and MRI image fusion is subjected to a multilabel optimization problem. The main aim is to minimize the data and smoothness cost during image fusion. To optimize the fusion parameters, the Modified Global Flower Pollination Algorithm is proposed. Here, six sets of fusion images with different experimental analysis are evaluated in terms of different evaluation metrics such as accuracy, specificity, sensitivity, SD, structural similarity index, feature similarity index, mutual information, fusion quality, and root mean square error (RMSE). While comparing to state‐of‐art methods, the proposed fusion model provides best RMSE with higher fusion performance. Experiments on a set of MRI and CT images of medical data set show that the proposed method outperforms a very competitive performance in terms of fusion quality.