bluuebunny/crossref_metadata_2025_split huggingface dataset:
The optimal degree of lateral wedge insoles for reducing knee joint load: a systematic review and meta-analysis
Authors: Ferreira Vitor , Simões Rita , Gonçalves Rui Soles , Machado Leandro , Roriz Paulo 
Published: December 2019

AbstractBackgroundLateral wedge insoles are traditionally used to reduce the adduction moment that crosses the knee during walking in people with medial knee osteoarthritis. However, the best degree to reduce knee joint load is not yet well established.MethodsElectronic databases were searched from their inception until May 2017. Included studies reported on the immediate biomechanical effects of different degrees of lateral wedge insoles during walking in people with knee osteoarthritis. The main measures of interest relating to the biomechanics were the first and second peak of external knee adduction moment and knee adduction angular impulse. For the comparison of the biomechanical effects of different degrees of insoles, the studies were divided in three subgroups: insoles with a degree higher than 0° and equal to or lower than 5°; insoles higher than 5° and equal to or lower than 9°; and insoles higher than 9°. Eligible studies were pooled using random-effects meta-analysis.ResultsFifteen studies with a total of 415 participants met all eligibility criteria and were included in the final review and meta-analysis. The overall effect suggests that lateral wedge insoles resulted in a statistically significant reduction in the first peak (standardized mean difference [SMD] –0.25; 95% confidence interval [CI] –0.36, − 0.13;P < 0.001), second peak (SMD –0.26 [95% CI –0.48, − 0.04];P = 0.02) and knee adduction angular impulse (SMD –0.17 [95% CI –0.31, − 0.03]; P = 0.02). The test of subgroups found no statistically significant differences.ConclusionSystematic review and meta-analysis suggests that lateral wedge insoles cause an overall slight reduction in the biomechanical parameters. Higher degrees do not show higher reductions than lower degrees. Prior analysis of biomechanical parameters may be a valid option for selecting the optimal angle of wedge that best fits in knee osteoarthritis patients with the lowest possible degree.
Direction of collaborative problem solving-based STEM learning by learning analytics approach
Authors: Chen Li , Yoshimatsu Nobuyuki , Goda Yoshiko , Okubo Fumiya , Taniguchi Yuta , Oi Misato , Konomi Shin’ichi , Shimada Atsushi , Ogata Hiroaki , Yamada Masanori 
Published: December 2019

AbstractThe purpose of this study was to explore the factors that might affect learning performance and collaborative problem solving (CPS) awareness in science, technology, engineering, and mathematics (STEM) education. We collected and analyzed data on important factors in STEM education, including learning strategy and learning behaviors, and examined their interrelationships with learning performance and CPS awareness, respectively. Multiple data sources, including learning tests, questionnaire feedback, and learning logs, were collected and examined following a learning analytics approach. Significant positive correlations were found for the learning behavior of using markers with learning performance and CPS awareness in group discussion, while significant negative correlations were found for some factors of STEM learning strategy and learning behaviors in pre-learning with some factors of CPS awareness. The results imply the importance of an efficient approach to using learning strategies and functional tools in STEM education.
Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221)
Authors: Ambrosone Christine B. , Zirpoli Gary R. , Hutson Alan D. , McCann William E. , McCann Susan E. , Barlow William E. , Kelly Kara M. , Cannioto Rikki , Sucheston-Campbell Lara E. , Hershman Dawn L. , Unger Joseph M. , Moore Halle C.F. , Stewart James A. , Isaacs Claudine , Hobday Timothy J. , Salim Muhammad , Hortobagyi Gabriel N. , Gralow Julie R. , Budd George T. , Albain Kathy S. 
Published: December 2019

PURPOSE Despite reported widespread use of dietary supplements during cancer treatment, few empirical data with regard to their safety or efficacy exist. Because of concerns that some supplements, particularly antioxidants, could reduce the cytotoxicity of chemotherapy, we conducted a prospective study ancillary to a therapeutic trial to evaluate associations between supplement use and breast cancer outcomes. METHODS Patients with breast cancer randomly assigned to an intergroup metronomic trial of cyclophosphamide, doxorubicin, and paclitaxel were queried on their use of supplements at registration and during treatment (n =1,134). Cox proportional hazards regression adjusting for clinical and lifestyle variables was used. Recurrence and survival were indexed at 6 months after enrollment using a landmark approach. RESULTS There were indications that use of any antioxidant supplement (vitamins A, C, and E; carotenoids; coenzyme Q10) both before and during treatment was associated with an increased hazard of recurrence (adjusted hazard ratio [adjHR], 1.41; 95% CI, 0.98 to 2.04; P = .06) and, to a lesser extent, death (adjHR, 1.40; 95% CI, 0.90 to 2.18; P = .14). Relationships with individual antioxidants were weaker perhaps because of small numbers. For nonantioxidants, vitamin B12 use both before and during chemotherapy was significantly associated with poorer disease-free survival (adjHR, 1.83; 95% CI, 1.15 to 2.92; P < .01) and overall survival (adjHR, 2.04; 95% CI, 1.22 to 3.40; P < .01). Use of iron during chemotherapy was significantly associated with recurrence (adjHR, 1.79; 95% CI, 1.20 to 2.67; P < .01) as was use both before and during treatment (adjHR, 1.91; 95% CI, 0.98 to 3.70; P = .06). Results were similar for overall survival. Multivitamin use was not associated with survival outcomes. CONCLUSION Associations between survival outcomes and use of antioxidant and other dietary supplements both before and during chemotherapy are consistent with recommendations for caution among patients when considering the use of supplements, other than a multivitamin, during chemotherapy.
Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects
Authors: van der Spoel Evie , Roelfsema Ferdinand , Akintola Abimbola A , Jansen Steffy W , Slagboom P Eline , Westendorp Rudi G J , Blauw Gerard J , Pijl Hanno , van Heemst Diana 
Published: December 2019

AbstractContextHormones of the hypothalamic-pituitary-target gland axes are mostly investigated separately, whereas the interplay between hormones might be as important as each separate hormonal axis.ObjectiveOur aim is to determine the interrelationships between GH, TSH, ACTH, and cortisol in healthy older individuals.DesignWe made use of 24-hour hormone serum concentrations assessed with intervals of 10 minutes from 38 healthy older individuals with a mean age (SD) of 65.1 (5.1) years from the Leiden Longevity Study. Cross-correlation analyses were performed to assess the relative strength between 2 24-hour hormone serum concentration series for all possible time shifts. Cross-approximate entropy was used to assess pattern synchronicity between 2 24-hour hormone serum concentration series.ResultsWithin an interlinked hormonal axis, ACTH and cortisol were positively correlated with a mean (95% confidence interval) correlation coefficient of 0.78 (0.74–0.81) with cortisol following ACTH concentrations with a delay of 10 minutes. Between different hormonal axes, we observed a negative correlation coefficient between cortisol and TSH of -0.30 (-0.36 to -0.25) with TSH following cortisol concentrations with a delay of 170 minutes. Furthermore, a positive mean (95% confidence interval) correlation coefficient of 0.29 (0.22–0.37) was found between TSH and GH concentrations without any delay. Moreover, cross-approximate entropy analyses showed that GH and cortisol exhibit synchronous serum concentration patterns.ConclusionsThis study demonstrates that interrelations between hormones from interlinked as well as different hypothalamic-pituitary-target gland axes are observed in healthy older individuals. More research is needed to determine the biological meaning and clinical consequences of these observations.
Denture cleaning — best practice
Authors: King Elizabeth , Jagger Robert 
Published: December 2019

Surveys have shown that many people do not clean their dentures effectively and suggest that the dental team may fail to educate patients in basic denture hygiene procedures. Poor denture hygiene can result in denture staining and malodour and is a risk factor for oral and systemic diseases. Methods available to clean dentures are described. Their modes of action, effectiveness and potential adverse effects are discussed. A combination of cleaning methods is probably more effective than any one method. Recommendations for effective denture cleaning that can be given to patients by the dental team are provided. CPD/Clinical Relevance: The dental team needs to explain effective approaches to denture hygiene to patients. Written information should also be provided to reinforce the message.
See a Pin and pick it up … radiographically!
Authors: Clark Ailish , Seenan Phillip , Gibson John , Donaldson Kirstyn 
Published: December 2019

A 67-year-old female was referred to secondary care with asymptomatic foreign bodies visible on intra-oral radiographs. Clinical examination was unremarkable. Radiographic examination revealed nine pin-like radio-opaque objects throughout the face and head present on multiple previous imaging modalities. The patient was unaware of their presence and could not account for them. A review of available literature revealed similar objects have been used during acupuncture and cosmetic procedures without complication. As the objects were asymptomatic, the patient was reassured and discharged. CPD/Clinical Relevance: Routine radiographic examination of patients may reveal the presence of unusual and unexpected findings.
Should dentists be more aware of the role of dietary supplements when assessing dental caries risk?
Authors: Thalukder Imran , Dhunna Ajay , Collard Mechelle 
Published: December 2019

Taking sports supplements is an increasing trend within the population and regular consumption of these supplements may increase the risk of developing caries. This paper focuses on identifying current evidence relating to caries risk and sports supplements, and also aims to investigate the sugar content of current sports supplements available in the UK. CPD/Clinical Relevance: Frequent sugar attacks causes caries. Dentists need to be aware that ingestion of sports supplements, eg protein bars/powders for some patients may contribute to the development of caries and this should form part of their caries risk assessment.
Dental trauma: management of complicated crown root fractures
Authors: Ayub Khawer , Darcey James 
Published: December 2019

Trauma of maxillary incisors is frequent and dental practitioners have to be competent in managing the consequences. Complicated crown root fractures of anterior teeth can have profound aesthetic and psychological implications on patients. In younger patients, if extractions are considered, it can lead to complex prosthodontic challenges in the future. Ideally, an attempt should be made in restoring the traumatized teeth, so an effective aesthetic and functional result can be reached. This case report highlights the treatment of complicated crown root fractures on maxillary incisors using endodontics and fragment re-attachment of the fractured crowns. Twelve-month follow-up of the treatment demonstrated aesthetic and functional success and delayed the need for prosthetic replacement. CPD/Clinical Relevance: This paper describes traumatic injuries of teeth and how management via fragment re-attachment of the fractured crowns has led to delay of definitive prosthetic treatment.
The orthodontic-surgical management of a patient with gorlin syndrome: a case report
Authors: Storey Madeleine , Caldwell Susi , Watkinson Simon , Patel Manu 
Published: December 2019

This case report describes the management of a patient following the incidental finding of multiple odontogenic keratocysts on an orthopantomogram by the patient's general dental practitioner (GDP). The cysts were extensive and had caused considerable displacement of the unerupted permanent teeth. Following marsupialisation, the teeth were aligned orthodontically. This article describes the features of odontogenic keratocysts, the associated Gorlin syndrome, and the management options available. The importance of close collaboration between the Oral and Maxillofacial Surgical and Orthodontic teams is highlighted. CPD/Clinical Relevance: Odontogenic keratocysts are benign but locally aggressive jaw cysts. They occur most commonly as solitary lesions in the jaws of healthy individuals, but may also be a feature of Gorlin syndrome. In young patients there is potential for severely displaced teeth to improve their position spontaneously and erupt.
Diagnosis and management of chronic osteomyelitis and cemento-osseous dysplasia of the mandible
Authors: Akram Arifa , Lidhar Tajinder , Valentine Katy Marie , Webb Roger 
Published: December 2019

Chronic osteomyelitis is a severe and persistent infection of the bone including the bone marrow. Cemento-osseous dysplasias are a group of conditions arising from the periodontal ligament tissue and are categorized into peri-apical, focal and florid. A case of a patient with buccal and submandibular swelling associated with a discharging sinus between LR45 was presented. History, examination and investigations confirmed a diagnosis of chronic osteomyelitis and an incidental finding of florid cemento-osseous dysplasia of the mandible. The patient's treatment is discussed within the context of important clinical considerations required in managing these patients. CPD/Clinical Relevance: It is pertinent for a general practitioner to be aware of signs and symptoms associated with chronic osteomyelitis and understand the management options.
Spontaneous dental abscesses in hereditary hypophosphataemic rickets: a preventive restorative approach in the primary dentition
Authors: Hughes Sara L , Hingston Emma J 
Published: December 2019

Patients with Hereditary Hypophosphatemic Rickets (HHR) commonly present with spontaneous dental abscesses and are often faced with a life-long burden of multiple endodontic treatments and/or extractions. Early diagnosis and management is essential to reduce risk of infection and maintain function and wellbeing. This is a case report of a 3-year-old boy with HHR, who presented with recurrent spontaneous abscesses in multiple primary teeth that subsequently required extraction. A preventive/restorative approach to protect the unaffected primary teeth is described and demonstrates how early clinical intervention can result in a symptom- and disease-free patient one year following treatment. CPD/Clinical Relevance: Oral manifestations are common in patients with HHR and early intervention by the clinician can contribute to reducing the risk of future complications.
Acute onset trismus in a 15-year-old
Authors: Mohammed Manal , Beech Andrea , Farrier Jeremy 
Published: December 2019

Trismus can be a common complaint encountered in general dental practice. A 15-year-old female presented to the Emergency Department with a history of acute onset and worsening trismus, pain and extra-oral swelling following placement of a restoration in the lower right first molar tooth. An initial diagnosis of trismus associated with either muscular spasm or a haematoma following an inferior alveolar nerve (IAN) block was assumed. The patient was reviewed the following week, the trismus and swelling having increased. An urgent MRI scan showed a large heterogeneous mass in the right masticator space. A biopsy under general anaesthetic diagnosed a rhabdomyosarcoma. The patient was referred to the oncology team for chemo/radiotherapy treatment. CPD/Clinical Relevance: Although ‘common things occur commonly’, it is important to remember that common symptoms and presentations can lead to more rare diagnoses. Prompt referral for specialist advice needs to be sought should first line management of trismus prove to be unsuccessful.
High-quality integrated microdisk resonators in the visible-to-near-infrared wavelength range on a 3C-silicon carbide-on-insulator platform
Authors: Fan Tianren , Wu Xi , Eftekhar Ali A. , Bosi Matteo , Moradinejad Hesam , Woods Eric V. , Adibi Ali 
Published: December 2019

In this Letter, we report, to the best of our knowledge, the first demonstration of high-quality integrated microdisk resonators (MDRs) on a 3C-silicon carbide-on-insulator (SiCOI) platform, working over a wide bandwidth from visible to near-infrared wavelengths. We show record-high quality factors for 3C-silicon carbide (SiC) MDRs of 242,000, 112,000, and 83,000 at the wavelengths of 1550 nm, 770 nm, and 650 nm, respectively, based on high-quality 3C-SiC films with the surface roughness as low as 1.4 Å, achieved by sample-transfer bonding, and precise chemical-mechanical polishing of the SiC film, to remove growth defects. Our study of 3C-SiC films grown on Si using transmission electron microscopy shows that even considerably higher-quality single-crystalline SiCOI can be achieved by flipping and thinning down an ultra-thick (∼5−10µm) 3C-SiC film grown on Si. The SiCOI platform can be used to realize ultra-wideband high-quality SiC devices that are desirable for applications in nonlinear and quantum photonics.
Diasporic Chinese family drama through a transnational lens: The Wedding Banquet (1993) and Saving Face (2004)
Authors: Han Qijun 
Published: December 2019

Abstract
The immigrant Chinese family has increasingly been represented in transnational Chinese cinema(s) over the past three decades. Two representative films, The Wedding Banquet (Lee, 1993) and Saving Face (Wu, 2004), are chosen to shed light on Chinese filmmakers' engagement with the complex process of identity formation for immigrants through the artifice of family conflict. Both movies examine how homosexuality can pose a threat to traditional Chinese family ethics such as filial piety, family continuity and family reputation, and how the seemingly incompatible ideological standpoints can be accommodated in the end. In both cases, on the one hand the depicted denial of homosexuality comes from its association with failed family education and bad ethnic and cultural practice, and its violation of traditional Chinese values. Therefore, sexuality becomes linked to the effect of Americanization and what it means to be Chinese. On the other hand, the 'undesirable' homosexual identity can be accepted or at least tolerated within the family as long as the family lineage is ensured, or the family remains intact. The disaporic subjects show us that submission to one's ethnicity can be modified or unlearned.
ESTADO DEL MIP DE Plutella xylostella (L.) (LEPIDOPTERA: PLUTELLIDAE) EN ARGENTINA
Authors: CURIS M. C. , BERTOLACCINI I. , LUTZ A. , FAVARO J. C. 
Published: December 2019

La polilla de las coles (Plutella xylostella) es una plaga cosmopolita que causa intensos daños a cultivos de Brassicaceas en todo el mundo. Las características de esta especie (ciclo corto, muchas generaciones al año, alta tasa de fecundidad), ayudaron a que haya generado resistencia a muchos insecticidas químicos, tanto puros como en mezclas, incluido biológicos como el Bacillus thuringiensis. A pesar de su importancia y de ser muy estudiada en el exterior, en Argentina se ha realizado poca investigación. En el presente artículo se analizan los avances en los conocimientos de esta plaga en Argentina y se dan pautas que ayuden a su manejo
FLORA FÚNGICA CONTAMINANTE NATURAL DE ARÁNDANOS (Vaccinium corymbosum L. O ́Neal) FRESCOS Y TRATADOS TÉRMICAMENTE
Authors: RIVAS M. Z. , PIAGENTINI A. M. , FRISÓN L. N. 
Published: December 2019

Se realizó el aislamiento e identifi cación de los mohos presentes en arándanos frescosy tratados térmicamente (10 minutos a 80°C), y se determinó su Abundancia (Ab) y Frecuencia (Fr).Se aislaron e identifi caron ocho especies de mohos en arándanos frescos y ocho especies de mohos en arándanos tratados térmicamente (mohos termorresistentes). Las especies de mohos aislados de arándanos frescos más frecuentes y abundantes fueron Aspergillus niger (Fr: 70% y Ab: 31%) y Penicillium decumbens (Fr: 21% y Ab: 11%). Las especies de mohos aislados de arándanos tratados térmicamente más frecuentes y abundantes fueron Arthrinium phaeospermun (Fr: 30% y Ab: 36%) y Eurotium repens (Fr: 13% y Ab: 21%). Los resultados obtenidos sirven como base para el diseño de tratamientos postcosecha que permitan reducir los mohos más frecuentes y abundantes presentes tanto en arándanos frescos como en aquellos destinados a procesamientos que incluyan una etapa de tratamiento térmico.
The effect of rs9930506 FTO gene polymorphism on obesity risk: a meta-analysis
Authors: Doaei S , Mosavi Jarrahi SA , Sanjari Moghadam A , Akbari ME , Javadi Kooshesh S , Badeli M , Azizi Tabesh Gh , Abbas Torki S , Gholamalizadeh M , Zhu ZH , Montazeri F , Mirzaei Dahka S 
Published: December 2019

AbstractObesity is associated with polymorphisms of the fat mass and obesity associated gene (FTO). This meta-analysis aimed to investigate the association of the rs9930506 FTO gene polymorphism and obesity. To the best of our knowledge, this study is the first meta-analysis to evaluate the relation between FTO rs9930506 polymorphism and obesity.We searched PubMed, Web of Science, and Embase to identify studies investigating the relations between the rs9930506 FTO gene polymorphism and obesity risk. We pooled adjusted odds ratios (OR) as overall and in continent subgroups. A Fixed-effects model was used to analyze the results of these studies in dominant and recessive models.By examining 3337 obesity cases and 3159 healthy controls, we identified 8 eligible case-control studies. Considering the dominant model of inheritance, there was a relationship between the rs9939506 polymorphism and obesity (OR=1.34 [1.03- 1.74]). The association remained significant in the European subgroup (OR=1.68 [1.2-2.36]), but not in the Asian subgroup. Using the recessive model, we also found a significant relationship when the overall association was investigated (OR=2.47; 95% CI 1.56-3.91). In conclusion, this study identified that the carriers of the risk allele of FTO rs9930506 polymorphism are at higher risk for obesity.