bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping with adequate and inadequate self-assessment of older people’s risk of falling: a mixed-methods study in Germany.
Authors: Strutz Nicole , Brodowski Hanna , Mümken Sandra , Müller-Werdan Ursula , Kiselev Jörn 
Published: December 2019

Abstract
Background: Older people are exposed to an increased risk of falling due to a multitude of physiological and functional changes and fear of falling. The risk of falling is assessed and managed differently. It should be found out whether the coping strategies of older people differ with regard to their activities in daily life depending on the adequacy of their self-assessed fall risk. Methods: Adequacy of the perceived fall risk was evaluated with the de Morton Mobility Index and the Activities-specific Balance Confidence Scale among 100 older people. Additionally, semi-structured interviews were conducted in 16 participants with an identified fall risk. Coding techniques, based on structuring qualitative content analysis and the half-split method were applied. Results: Six out of 16 interviewees assessed their fall risk adequately. Interviews with the seniors resulted in topics such as coping strategies and awareness and several sub-topics in each category. Participants who adequately assessed their own fall risk reported an “active/positive” coping behavior and awareness of themselves. In contrast, those who assessed their own risk of falling inadequately covered all identified categories with no identifiable pattern. Conclusion: An adequate self-assessment of fall risks is accompanied by positive coping strategies to maintain an active lifestyle. In contrast, a lack of an adequate self-awareness seems to lead to arbitrary coping strategies. Assisting older people in their self-awareness regarding their own fall risk should be emphasized in order to adopt positive coping strategies. Future studies are necessary to better understand the underlying mechanisms that lead to an adequate or inadequate self-assessment in older people fall risk.
A LINC00266-1/miR-548c-3p/SMAD2
Authors: Zheng Shengnai , Wan Li , Ge Dawei , Jiang Fan , Qian Zhanyang , Tang Jian , Yang Jin , Yao Yilun , Yan Junwei , Zhao Lei , Li Haijun , Yang Lei 
Published: December 2019

Abstract
The authors have withdrawn this preprint from Research Square
Association between uric acid level and incidence of macroalbuminuria in people with type 2 diabetes mellitus: A 4.5-year cohort study
Authors: Lai Yun-Ju , Chen Yu-Yen , Chen Li-Jung , Ku Po-Wen , Hung Kuo-Chuan , Yen Yung-Feng , Lin Yu-Kai 
Published: December 2019

Abstract
Background: Using animal models and molecular biology researches, hyperuricemia has been shown to instruct renal arteriolopathy, arterial hypertension, and microvascular injury involving the renin-angiotensin system and resulting in renal function impairment. Nevertheless, the association between uric acid levels and the development of macroalbuminuria has been under-investigated in people with type 2 diabetes mellitus. Methods: Patients with type 2 diabetes and regular outpatient visits were recruited from a community hospital in Taiwan since January 2014. Demographics, lifestyle features, and medical history were gathered by well-trained interviewers. All participants underwent comprehensive physical examinations, including a biochemical assay of venous blood specimens and urine samples after an 8-hour overnight fast. Participants were followed until June 2018. The primary outcome was the macroalbuminuria incidence. Univariable and multivariable Cox regression analysis were employed to explore the relation between uric acid and incident macroalbuminuria. Uric acid cutoffs for incident macroalbuminuria were determined with the receiver operator characteristic curve. Results: We included 247 qualified subjects (mean age: 64.78 years old [standard deviation=11.29 years]; 138 [55.87%] men). During a 4.5-year follow-up duration, 20 subjects with incident macroalbuminuria were recognized. Serum uric acid was significantly associated with an increased risk of incident macroalbuminuria (adjusted hazard ratio=2.39; 95% confidence interval: 1.53-3.75; p<0.001) with potential confounders adjustment. The uric acid cutoff point was 6.9 mg/dL (area under the curve 0.708, sensitivity 60.0%, specificity 84.58%) for incident macroalbuminuria. Conclusions: Serum uric acid was associated with incident macroalbuminuria among people with type 2 diabetes.
Investigating the effect of paricalcitol on serum FGF23 in vitamin D deficient rats
Authors: Saki Forough , Omrani Gholamhossein Ranjbar , Koohpeyma Farhad 
Published: December 2019

Abstract
Background: We conducted this study to discover changes of serum FGF23 in non-uremic rat model of vitamin D deficiency without secondary hyperparathyroidism using paricalcitol. Methods: 30 adult male rats weighting 300±20 grams were enrolled. They were divided into three groups of 10 rats including Control, Vitamin D deficient(VDD), and Vitamin D deficient diet treated with paricalcitol(VDD+P). Serum biochemical were checked twice, at baseline and after the 22nd day of study. Results: There was no significant difference in baseline laboratory data between groups. At the end of the study, 1,25(OH)D3 was reduced in VDD (P = 0.019) and VDD+P (P < 0.001) with a more significant decline in VDD+P group. Serum level of FGF23 was reduced in VDD+P group compared to the control group (P = 0.011) and VDD group (P = 0.021). serum PTH in VDD group was higher than the control and VDD+P group (P = 0.036 and P = 0.038, respectively). Conclusion: The present study showed that paricalcitol could reduce FGF23 in vitamin D deficient rats without any changes in serum calcium, phosphorous and fractional excretion of phosphorous, which might be due to low PTH and 1,25(OH)2 D3.
Study on landscape quality evaluation of Urban Forest Park: a case from China
Authors: Sun Tao , Han Xiuyan , Cao Tianyi 
Published: December 2019

Abstract
Background: Nanjing Zijinshan National Forest Park is a 5A level scenic spot approved by the Chinese government and a world-famous tourist attraction. Due to the decrease of forest coverage and the environmental pollution caused by the large scale of tourism, the requirements of landscape quality evaluation of urban forest parks are put forward. Results: In order to explore assessment methods of landscape quality (LQ) of Urban Forest Park, based on the literature review and current situation analysis, this paper selected 26 assessment indexes of five categories to construct the index system of comprehensive landscape quality assessment of urban forest parks. In view of requirements of landscape quality assessment of urban forest parks, niche suitability model (NSM) was introduced. On the basis of analysis and improvement, spatial niche suitability model (SNSM) was constructed combining absolute niche suitability model and relative niche suitability model by using weighted average method. Then, the application test of SNSM was carried out taking Nanjing Zijinshan National Forest Park as the research target. Conclusions: The assessment results show that the landscape quality of Nanjing Zijinshan National Forest Park showed a slow upward trend from 2000 to 2018, and was at the lower middle level in 5A scenic area; at the same time, due to buildings increasing and environmental pollution, forest landscape quality showed a slow downward trend. The assessment results of spatial niche suitability model are in line with the actual situation of landscape quality of Nanjing Zijinshan National Forest Park, and provide an effective quantitative analysis method for urban forest parks to strengthen landscape quality management and prevent landscape quality risks. Keywords: Landscape quality; urban forest park；spatial niche suitability model; comprehensive assessment；Nanjing Zijinshan National Forest Park
Multivariate machine learning models for prediction of postoperative intestinal obstruction in patients underwent laparoscopic colorectal surgery: A retrospective observational study
Authors: Li Xueyan , Ma Genshan , Qian Xiaobo , Wu Yamou , Huang Xiaochen , Gu Chengyong 
Published: December 2019

Abstract
Background Machine learning may predict postoperative intestinal obstruction (POI) in patients underwent laparoscopic colorectal surgery for malignant lesions.Methods We used five machine learning algorithms (Logistic regression, Decision Tree, Forest, Gradient Boosting and gbm), analyzed by 28 explanatory variables, to predict POI. The total samples were randomly divided into training and testing groups, with a ratio of 8:2. The model was evaluated by the area operation characteristic curve (AUC), F1-Measure, accuracy, recall, and MSE under the receiver.Results A total of 637 patients were enrolled in this study, 122 (19.15%) of them had POI. Gradient Boosting and gbm had the most accurate in training group and testing group respectively.The f1_score of Gradient Boosting was the highest in the training group (f1_score =0.710526), and the f1_score of gbm was the highest in the testing group (f1_score =0.500000). In addition, the results of the importance matrix of Gbdt algorithm model showed that the important variables that account for the weight of intestinal obstruction after the first five operations are time to pass flatus or passage of stool, cumulative dose of rescue opioids used in postoperative days 3 (POD 3), duration of surgery, height and weight.Conclusions Machine learning algorithms may predict the occurrence of POI in patients underwent laparoscopic colorectal surgery for malignant lesions, especially Gradient Boosting and GBM algorithms. Moreover, time to pass flatus or passage of stool, cumulative dose of rescue opioids used during POD 3, duration of surgery, height and weight play an important role in the development of POI.
Comparison of Lateral Abdominal Muscle Thickness and Cross-Sectional Area of Multifidus in Adults with and without Scoliosis
Authors: Rahmani Nahid 
Published: December 2019

Abstract
Background: Scoliosis is common in students with a prevalence of 1-2% in teenagers and more than 50% in adults ≥ 60 years. The aim was to compare the abdominal and multifidus muscles size in adults with and without scoliosis. Methods: Forty men with and without scoliosis were recruited. The Visual Analogue Scale and the Oswestry Disability Questionnaire were used to evaluate the pain intensity and functional disability in the patients’ group, respectively. Subjects were asked to lie down in a supine position with their knees bent to measure abdominal muscles using sonography. The linear transducer was placed vertically on the anterolateral abdominal wall to record images of the abdominal muscles (Transversus abdominis, internal oblique, external oblique). To assess the lumbar multifidus muscle size, the curvilinear head was used horizontally on the multifidus muscle at the L5-S1 level in a prone lying position. Results: No significant difference was found between the two groups for demographic variables. A significant difference was found between the healthy subjects and patients with scoliosis for right and left abdominal and multifidus muscles size (p<0.05). No significant difference was reported between the two sides of the convexity and concavity on muscles size in patients with scoliosis (p>0.05). Conclusions: According to the results, patients with scoliosis had smaller abdominal and lumbar multifidus muscles size, but no significant differences were found between the muscle size of the concave and convex sides in the scoliosis group. Future work is needed to support the findings of the current study.
Clinicopathological difference of gastric cancer between lesser and greater curvature
Authors: Li Guocai , Zhao Qing-Chuan , Zhang Hong-Wei , Yang Peng , Pang Fang-Ning , Xu Long-Long , Wu Xin-An 
Published: December 2019

Abstract
Background: Gastric cancer(GC) is heterogeneous disease, recent years has established a molecular classification and described distribution of molecular subtypes in stomach. However, the clinicopathological difference of gastric cancer between lesser and greater curvature is still unknown. In this study, we investigated the clinicopathological difference of gastric cancer between lesser and greater curvature. Methods: Between January 2010 and August 2014, 1249 consecutive patients with GC located at lesser or greater curvature were treated in our surgery department, the data of demographic, pathological type, differentiation, tumor size, TNM stage, tumor markers, operative methods, complications and follow-up data were analyzed by univariant analysis and Kaplan-Meier analysis retrospectively. Results: We found the tumor size in lesser curvature was larger than in greater curvature (4.95±2.57 vs. 4.43±2.62cm, P=0.034); The patients with gastric cancer in lesser curvature had a higher incidence of total gastrectomy, but a lower incidence of distal gastrectomy than it in greater curvature (60.2% vs. 43.2%, and 34.8% vs. 49.2%, P=0.002); The 5-year survival rate of gastric cancer between the curvatures was not statically significant (62.6±0.02% vs.66.1±0.06%, P=0.496); The rate of EGFR expression in lesser curvature was 40.55%, which was significantly higher than that in greater curvature (25.92%，P=0.024), and the 5-year survival rate in patients with EGFR positive was 50.8±0.06%, which was significantly lower than that in patients with EGFR negative (64.8±0.03%，P=0.021). Conclusions: Our results suggest that the clinicopathological difference of gastric cancer is significant between lesser and greater curvature. Emphasizing the difference contribute to improve outcome of treatment.
Please pay attention to the competency of Chinese primary clinical medical workers in electrocardiogrophic interpretation skills
Authors: Gao Yu-lei , Li Yan-hua , Li Jie , Wang Chun-xue , Liu Yan-cun , Li Chen , Yao Ying , Shou Song-tao , Chai Yan-fen 
Published: December 2019

Abstract
Background: Improving the capacity of health care, disease diagnosis and treatment of primary medical workers was the key to hierarchical diagnosis and treatment services. Electrocardiogram (ECG) played an important role in the diagnosis of cardiac diseases and should be regarded as the most basic tool for primary clinical medical workers in China. Objectives: To investigate the competency of Chinese medical workers in electrocardiographic interpretation skills, especially in the primary care hospitals, to explore the insufficiency of electrocardiographic interpretation skills and the improvement methods. Methods: A cross-sectional questionnaire study was conducted via the internet from March to October 2019. The questionnaire consists of 6 parts: basic information, equipping with an electrocardiograph, operating electrocardiograph, receiving electrocardiographic theory, testing of electrocardiographic interpretation, and improving electrocardiographic interpretation skills. Results: The effective quantity of this questionnaire was 2307, with an effective rate of 96.57%. The overall reliability was α=0.895. There were no significant differences among primary, private and class-Ⅲ hospitals in the aspects of equipping with an electrocardiograph (χ2=3.794, 3.104, P＞0.05), operating the electrocardiograph (χ2=1.857, P＞0.05) and receiving electrocardiographic theoretical study (χ2=6.701, P＞0.05). Medical workers in private and class-Ⅲ hospitals had a stronger interpretation competency of ECG, including common or life-threatening ECGs (P＜0.01). The development of talent echelon in primary hospitals affected the electrocardiographic interpretation skills of medical workers (P＜0.01). In primary hospitals, the age was mainly ≥ 40 years (79.0%), the education background was mainly bachelor and below degree (80.9%), the professional qualification was mainly physician assistant (58.6%) and primary physician (31.4%). The interpretation competency of ECG of medical workers in private or class-Ⅲ hospitals was higher than that in primary hospitals (P＜0.05 or 0.01). Conclusions: In China, the examination of electrocardiograph had been popularized. Due to the unreasonable development of talent echelon in primary hospitals, the electrocardiographic interpretation skills of primary medical workers were worrying. We should improve electrocardiographic teaching methods with the help of the internet, to enhance the electrocardiographic interpretation skills of primary medical workers.
From clinical guidelines to clinical care – does employee involvement make a difference to implementation?
Authors: Kleve Liv , Skarstein Line Setre , Elgen Irene 
Published: December 2019

Abstract
Background: Implementation of new knowledge into routine care is a complex endeavour that requires innumerable variables. Involving employees in the change process, good planning and communication as well as a commitment to training has been highlighted as important factors for successful implementation. Acknowledging change as a process may also be helpful. The aim of this paper was to describe the initial phase of the implementation process in changing practices within a child and adolescent mental health service.Method: Prior to the five-year project, an external service evaluation was carried out. The employees expressed a need for a clear direction from management to guide their clinical practice. A vision and strategy for the service was developed. Employees participated in the process of developing clinical standards during the first phase of implementation. Results: Fixsen’s four stage model and the PSDA circle were used to guide the implementation process. The employees developed a template for clinical standard based on national and international clinical guidelines. During the period, 17 clinical standards were established and 10 new evidence based methods were implemented. All service leads (13) and a group of senior clinicians (32) were invited to participate in an evaluation five years after the initial service evaluation. There was overall agreement that the mental health service was developing positively ensuring high quality services for children and adolescents. In addition, both groups agreed that the introduction of clinical standards was important in ensuring quality care.Conclusion: Involving employees in the implementation process seemed to be an important factor in successfully changing a mental health service.
Methodology quality and grading recommendations in cancer screening guidelines: a systematic review
Authors: Li Jiang , Ni Li , Pengtao Yao , Yajing Tong , Min Yang , Yaolong Chen , Xiaoshuang Feng , Zhangyan Lv , Xiaoqin Wang , Kehu Yang , Min Dai , Wanqing Chen 
Published: December 2019

Abstract
Introduction: Cancer prevention and screening guidelines are ideally suited to the task of providing high-quality and effective screening in clinical practice. We systematically reviewed cancer screening guidelines for recommended cancer prevention and screening interventions, in order to provide recommendations for development and implementation of high-quality guidelines. Methods: We included cancer screening and prevention recommendations mainly on lung, breast, gastric, liver, colorectal, and prostate from Pubmed, Embase, Web of Science, China Knowledge Resource Integrated Database, Wanfang Data, SinoMed, and then searched in other organizations’ website and database such as the United States Preventive Services Task Force, the American Cancer Society, the American College of Physicians, the National Comprehensive Cancer Network, the National Institute for Health and Care Excellence, European Society for Medical Oncology, and the National Guidelines Clearinghouse until June 30, 2018. An abstraction form to code information according to AGREE II was made and four researchers completed separately. The primary outcome was each recommendation’s quality; the second outcome was benefit-harm “comparability” rating, based on how benefits and harms were presented. Results: There are no high-quality guides in the 19 guides because each domain 3 didn’t reach 60 points, and only 2 guides scored above 50 points. 10 recommendations 9 guidelines were included, year from 2010 to 2018. The majority of guidelines (67%) were supported by a systematic review and that most guidelines had explicit criteria for rating the quality and strength of evidence (64% and 73%, respectively). 7 guidelines clearly mentioned benefits and harms, and 2 only mentioned relevant content. Four of the 55 recommendation statements we reviewed presented the benefits of the intervention in terms of a relative risk reduction (larger number) while presenting the harms in terms of an absolute risk reduction (smaller number). Conclusions：Our findings led us to consider potential contributors to the lack of clarity in guidelines. We recommend the use of “summary of findings” tables, an approach proposed in a series of papers from the GRADE guidelines group, as the best method of summarizing and presenting outcome information.
The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis
Authors: Wang Sen , Wu Jia , Wang Junjun 
Published: December 2019

Abstract
Background: Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the metabolism of tryptophan into kynurenine. It is considered to be an immunosuppressive molecule that plays an important role in the development of tumors. However, the relationship between IDO and solid tumor prognosis remains unclear. Herein, we retrieved relevant published literature and analyzed the relationship between IDO expression and prognosis in solid tumors.Methods: Studies related to IDO expression and tumor prognosis were retrieved using PMC, EMbase and web of science database. Overall survival (OS) and other data in each study were extracted. Hazard ratio (HR) was used for analysis and calculation, while heterogeneity and publication bias between studies were also analyzed.Results: A total of 29 studies were included in this meta-analysis. Overall, high expression of IDO was significantly associated with poor OS (HR 1.98, 95% CI 1.55–2.53) and TTP (HR 2.25 95% CI 1.58–3.22). Subgroup analysis suggested that the associations between IDO expression and poor OS were significant in the prospective studies without obvious heterogeneity.Conclusions: The high expression of IDO was significantly associated with the poor prognosis of solid tumors, suggesting that it can be used as a biomarker for tumor prognosis and as a potential target for tumor therapy.