bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant and Cytotoxicity Activity of Phenolic Compounds from Piper sarmentosum Roxb. Against T47D Human Breast Cancer Cell
Authors: Ghazali Nor Farahiyah , Mustafa Farah Farisha , Muhammad Tengku Sifzizul Tengku , Ibrahim Maizatul Akma 
Published: October 2019

Background:
Cancer is a major public health burden worldwide. Breast cancer tops the
chart as the most common cancer of today and has become the major cause of death inthe female
population. Approximately 60% of currently applied cancer drugs are derived from natural sources.
Piper sarmentosum Roxb. is one of the natural plants that had been traditionally used as herbal
medicine. Phytochemical compounds from this plant were reported to be important in the promotion
of human health, mainly due to its phenolic compounds, which have been linked with various biomedical
properties.

Objective:
To identify the phenolic profile of P. sarmentosum leaves methanolic extract and to investigate
the antioxidant and cytotoxicity activity on human breast carcinoma cells, T47D.

Methods:
Methanolic extract of P. sarmentosum leaves was analyzed by using Folin-Ciocalteu
method and High Performance Liquid Chromatography (HPLC). In vitro antioxidant study of the
extract was carried out using diphenylpicrylhydrazyl (DPPH) scavenging test. In vitro cytotoxicity
assay was conducted by using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-
sulfophenyl)-2H-tetrazolium (MTS) assay. Biochemical test of DNA fragmentation was also applied
to study the extract’s cytotoxicity effect on T47D mode of cell death.

Results:
The Total Phenolic Content (TPC) for the P. sarmentosum extract was 89.33 mg GAE/g
DM and HPLC revealed the presence of flavonoids and phenolic acids. From the DPPH assay, P.
sarmentosum extract exhibited antioxidant activity with the EC50 at 60.24 μg/mL. The cytotoxicity
analysis by MTS assay showed the treatment of T47D cells with the plant extract that caused cytotoxic
effect on the cells, with an IC50 value of 2.69 μg/mL. The DNA fragmentation assay on the extract-
treated T47D cells exhibited internucleosomal DNA fragmentation of the cell's genome on an
electrophoresis agarose gel.

Conclusion:
The phenolic compounds identified from P. sarmentosum have cytotoxic effects
against breast cancer cells, T47D. These compounds could be a promising anticancer agent candidate
for breast cancer treatment. Further studies on the isolation, structural elucidation and mechanism
of action on the active compounds are required prior to in vivo and clinical study.
Recent Developments and Potential of Mucoadhesive Buccal Drug Delivery System for Oro-mucosal Disorders
Authors: Sharma Deepak , Garg Rajeev 
Published: October 2019

Background:The drug delivery across buccal mucosa is a very interesting option for the treatment of various oro-mucosal disorders such as aphthous stomatitis, periodontitis, gingivitis, toothache, periodontitis, and sjorgensen syndrome. But it is quite difficult because of target site movements, limited area for drug absorption, drinking of fluids, intake of food and saliva flow at regular intervals, contributing to poor retention and sub-therapeutic level of drug at the target site. Due to this, the mucoadhesive buccal drug delivery system has gained a great deal of attention among the various scientists and researchers over the last two decades.Methods:Mucoadhesion is a process of attachment between the natural or synthetic macromolecule and mucosal epithelial surface with the aid of interfacial attractive forces. The process of mucoadhesion has been extensively encouraged by the utilization of mucoadhesive polymers within the formulation that on contact with salivary fluid swells and adheres to buccal epithelium membrane, thus prolonging the drug release, retention time and improving therapeutic performance in case of oral diseases. The present review tries to cover the basic anatomy and structure of oral mucosa, pathways of drug absorption, the theory of mucoadhesion, mechanisms involved in mucoadhesion and various factors affecting mucoadhesion.Results:It highlights the properties of mucoadhesive polymers in drug delivery along with various dosage forms such as mucoadhesive tablets, films, patches, gels, and pastes. Furthermore, it also sheds light on the recent developments made in the field of mucoadhesive buccal drug delivery system that reflects the potential of this system for the effective treatment of oro-mucosal disorders.Conclusion:It can be concluded that the mucoadhesive buccal drug delivery system has great potential in the near future for treating oro-mucosal disorders.
PENCUCIAN MEMPENGARUHI MUTU SURIMI CUCUT (Carcharhinus sp.)
Authors: Husni Amir , Lelana Iwan Yusuf Bambang 
Published: October 2019

Shark is one of low value fishes in Yogyakarta. In order to increase the value, shark was processed into surimi. In this research, shark was processed into surimi with different washing time frequency (0, 2, 4, and 6 times) to investigate the gel properties of shark surimi.Gel strength of shark surimi increased as the washing time frequency increased from 0 to 6 times. The 4 and 6 washing time showed similar gel strength and sensory characteristics. Shark surimi with 6 washing time and pre-incubation at 40oC followed by cooking at 90oC produced the highest gel strength.
IMPLIKASI MODEL BIOEKONOMI TERHADAP MANAJEMEN PERIKANAN TANGKAP: STUDI KASUS DI PANTAI SELATAN YOGYAKARTA
Authors: Suadi Suadi , Soeparno Soeparno , Widianingroem Retno 
Published: October 2019

Small-scale marine capture fisheries have contributes to community welfare at Yogyakarta’s south coast. Government has planned some programs to develop fisheries. The development supposed only at rational effort in which fishers still gain advantages. Precautionary approach using bio-economic model of Gordon-Schaefer was applied to analyze the issue. The linear regression model of catch per unit of effort (C/f) (CPUE) and effort (f) was C/f = 59,851 – 0,0005f (R2 = 82, 71%). Fish price assumed at Rp 7,735.19 /kg with operational cost of Rp 59,835.67/trip. Total revenue and effort at maximum sustainable yield was predicted at Rp 13,396 billion and 56,860 trip (equals to 327 vessels), respectively. Fisher income at this level was Rp 167,774.51/trip/vessel. Fish exploration level in this area has already closed to total allowable catch. Free access equilibrium in which cost is equal to revenue might reach at effort of 102,231 trip (equals to 568 vessels). Managing fisheries at maximum economic yield might rise fisher income 17.83% comparing to maximum sustainable yield, but total revenue decreased 1.77% at 56.13% of existing effort. Some management strategies should be promoted and regulated for the fishery exploitation. Based on the results, those possible strategy were 1) limiting investment through regulation and permission; 2) improvement of fishers productivity through technology improvement to exploit under-used fish resources; 3) expanding the fisheries activity to offshore through harbor development and social preparation; 4) marketing improvement through revitalization of fish action; 5) improving hadling and post harvest fish technology through training and extension; 6) the increasing of bargaining position through empowering fishers group; 7) promoting alternate incomes through integrated coastal tourism development; and 8) avoiding competition and conflict through developing Java’s south coast cooperation. Participatory approach in planning, developing and evaluating should be promoted to develop fishery a southern coast of Yogyakarta.
A ORTOPEDIA FUNCIONAL COMO POSSIBILIDADE TERAPÊUTICA PARA TRATAMENTO DA MALOCLUSÃO NA DOENÇA FALCIFORME
Authors: Ladeira Casado Priscila 
Published: October 2019

Palavras-chave: Anemia falciforme; Ortopedia funcional; Odontologia; Maloclusão. Key Words: Sickle cell; Functional orthopedics; Dentistry; Malocclusion.
INTUBAÇÃO SUBMENTONIANA: REVISÃO DE LITERATURA E DESCRIÇÃO DA TÉCNICA CIRÚRGICA
Authors: Daflon De Faria Walace 
Published: October 2019

A intubação submentoniana ou também conhecida como submento-oro-traqueal é uma técnica que conquistou diversos cirurgiões maxilofaciais ao longo dos anos, que por sua vez realizaram algumas pequenas alterações de acordo com seus conhecimentos anatômicos e vivência profissional. É um procedimento considerado seguro, fácil, rápido e de baixa morbidade. Por esse motivo é utilizada como alternativa para a traqueostomia, largamente utilizada e que possui maiores chances de complicações pós-operatórias. A intubação esta indicada para cirurgias de traumas panfaciais, em que há necessidade de manusear a oclusão do paciente no transoperatório, bem como em situações em que as técnicas consideradas mais convencionais, intubação orotraqueal e nasotraqueal, são contraindicadas. Além disso, atualmente pode ser indicada para cirurgia ortognática bimaxilar com rinoplastia simultânea, rinoplastia isolada e uma alternativa viável para pacientes portadores de fissura labial e/ou palatina. O objetivo deste trabalho é discutir as indicações e contraindicações deste método de intubação através de uma revisão de literatura, além de descrever os passos para sua execução. Palavras-Chaves: Trauma Maxilofacial; Intubação; Submento-Oro-TraquealABSTRACT The submental intubation or also known as submento-oro-traqueal is a technique that has conquered several maxillofacial surgeons over the years, in turn performed some small instances according to their anatomical knowledge and professional experience. It is a procedure considered safe, easy, fast and of low morbidity. For this reason it is used as an alternative to the widely used tracheostomy and has a higher chance of postoperative complications. Intubation is indicated for panacea trauma surgeries, in which there is a need to handle the occlusion of the patient in the intraoperative period, as well as in situations in which the techniques considered more conventional, orotracheal and nasotracheal intubation are contraindicated. In addition, it may currently be indicated for bimaxillary orthognathic surgery with simultaneous rhinoplasty, rhinoplasty alone and a viable alternative for patients with cleft lip and / or palate. The objective of this study is to discuss the indications and contraindications of this method of intubation through a literature review, in addition to describing the steps for its execution. Key words: Maxillofacial Trauma; Intubation; Submento-Oro-Tracheal.
Shareholder Litigation and the Information Content of Management Voluntary Disclosure
Authors: Ma Yuanyuan 
Published: October 2019

ABSTRACT
I study the information content of management voluntary disclosures disciplined by shareholder litigation. I model the litigation mechanism in which legal liabilities are based on the damages that shareholders suffer from buying a stock at an inflated price. I find that management does not fully reveal private information in equilibrium. Instead, their disclosures reveal only a range in which their private information lies. Thus, the precision of information is, to some extent, lost. Notably, increasing the severity of legal liability does not always reduce the loss of precision. In fact, when the legal liability reaches a certain level, more severe legal liability will result in less precise disclosures. I also find that good news and bad news have different precision. Specifically, good news is more precise than is bad news when legal liabilities are high, and bad news is more precise than is good news when legal liabilities are low.
Big 4 Alumni's Attitudes and Behavior Toward their Former Firm
Authors: Cannon Nathan H. , Herda David N. , Puffer Thomas M. 
Published: October 2019

SUMMARY
This article summarizes a recently published academic study (Cannon, Herda, and Puffer 2019) that examines factors associated with Big 4 alumni's proclivity to benefit their former firm by recommending the firm to others as a potential service provider or employer (i.e., post-employment citizenship). Based on social exchange theory, our study predicts and finds that alumni who perceive their firm treated them fairly and supported them during their time with the firm are more committed to the firm, and therefore more likely to engage in post-employment citizenship. Although we find that firm commitment decreases after individuals exit the firm, our results suggest that the firm's alumni outreach efforts (both formal and informal) can help soften this decline. Practical implications for audit firms are discussed.
Bank Audit Fee Pressure During the Financial Crisis
Authors: Porter Christine M. 
Published: October 2019

SUMMARY
This study examines the pressure on bank audit fees during the height of the financial crisis. I employ a prior year benchmark audit fee method and compare it to the actual audit fee to determine the amount of fee pressure applied in a year. Results show a significant amount of fee pressure exerted upon bank auditors during 2008, more so than that found in studies of other industries. This study also investigates a bank specific fee model during the crisis finding differences in determinants of fees for those banks that did apply fee pressure.
JEL Classifications: M42.
Clinging to Excel as a Security Blanket: Investigating Accountants' Resistance to Emerging Data Analytics Technology
Authors: Schmidt Pamela J. , Church Kimberly Swanson , Riley Jennifer 
Published: October 2019

ABSTRACT
While many business publications stress the importance of data analytics skills and technology, The Wall Street Journal reports strong reactions of accountants faced with a move away from Excel. Accountants are traditionally the reliable source for business information, but that position may be eroded by the emerging profession of data analysts. Looking to the future, Big Four accounting firms stress the need for data analysis skills, and universities are launching degree programs. But what is the reaction of current working professionals? Are they heeding the call for data analytics? Evidence indicates there is some resistance to adoption of data analytics practices. This research proposes the use of Status Quo Bias Theory to investigate the reactions of accounting professionals across the spectrum of accounting sub-disciplines. The study seeks to understand factors that may influence practicing accountants' resistance to adopting new data analysis technologies.
Blockchain Technology, Business Data Analytics, and Artificial Intelligence: Use in the Accounting Profession and Ideas for Inclusion into the Accounting Curriculum
Authors: Qasim Amer , Kharbat Faten F. 
Published: October 2019

ABSTRACT
Recently, accounting academics have reported increased attention in the accounting profession toward the employment of various technologies. These studies only highlight the exploitation of these technologies in the profession and areas for future research, while missing the need for modernizing the accounting curriculum to meet the industry's technological needs. This paper follows an integrated model for curriculum redesign to reflect blockchain technology, business data analytics, and artificial intelligence employment in the accounting profession. By building on the main four educational curricula designs components, we propose ways to incorporate these technologies into the accounting curriculum. Current industry implementation of new technologies should be considered by academia when designing accounting curriculum to prepare graduates for the market and to ensure their employability. This paper calls for radical changes in the accounting curriculum to reach a balance between existing accounting knowledge and information technology skills relevant to the profession.
JEL Classifications: M4; I23; O33.
Kondisi Ekosistem Mangrove di Kawasan Ekowisata Karangsong Kabupaten Indramayu
Authors: Tufliha Aulia Rosdiana , Putra Daffa Manggala , Amara Delima Mentari , Santika Ressa Muhammad , Oktavian Sandra Moerti , Kelana Perdana Putra 
Published: October 2019

Ekosistem mangrove di wilayah Karangsong Kabupaten Indramayu merupakan salah satu ekosistem hasil rehabilitasi yang dimanfaatkan menjadi kawasan ekowisata. Penelitian dilaksanakan pada bulan Agustus 2018 di Kawasan Ekowisata Karangsong Kabupaten Indramayu guna mengetahui kondisis ekosistem mangrove dengan menggunakan metode Transek Line Plot (TLP). Stasiun pengamatan diambil berdasarkan waktu rehabilitasi dan keterwakilan wilayah pada bagian selatan, bagian tengah dan bagian utara kawasan ekowisata mangrove Karangsong. Berdasarkan hasil penelitian, terdapat komposisi jenis dari dua spesies mangrove yaitu Avicennia marina dan Rhizophora mucronata. Kerapatan pada tingkat pohon di ekosistem mangrove Karangsong termasuk kedalam kategori rusak pada seluruh stasiun dengan nilai kerapatan masing-masing sebesar 633 ind/ha untuk stasiun 1, 366 ind/ha untuk stasiun 2 dan 100 ind/ha stasiun 3, tetapi menuju perkembangan kearah yang lebih baik ditunjukan dengan nilai kerapatan yang tinggi pada tingkat pancang dan semai. Parameter kualitas air seperti suhu, salinitas dan pH perairan serta jenis substrat berlumpur mendukung untuk pertumbuhan mangrove.
Evaluation of phenylethylamine type entactogens and their metabolites relevant to ecotoxicology – a QSAR study
Authors: Takač Milena Jadrijević-Mladar , Magina Joao Daniel Casimiro , Takač Tin 
Published: October 2019

Abstract
The impact of the selected entactogens and their o-quinone metabolites on the environment was explored in QSAR studies by the use of predicted molecular descriptors, ADMET properties and environmental toxicity parameters, i.e., acute toxicity in Tetrahymena pyriformis (TOX_ATTP) expressed as Th_pyr_pIGC
50/mmol L−1, acute toxicity in Pimephales promelas, the fathead minnow (TOX_FHM) expressed as Minnow LC
50/mg L−1, the acute toxicity in Daphnia magna (TOX_DM) expressed as Daphnia LC
50/mg L−1 and bioconcentration factor (BCF).
The formation of corresponding o-quinones via benzo-dioxo-lone ring, O-demethylenation was predicted as the main metabolic pathway for all entactogens except for 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)propan-2-amine (DiFMDA). The least favourable ADMET profile was revealed for N-(1-(benzo[d][1,3]dioxol-5-yl)propan-2-yl)-O-methylhydroxylamine (MDMEO).
QSAR studies revealed significant linear correlations between MlogP of entactogens and MlogP of o-quinone metabolites (R = 0.99), and Th_pyr_pIGC
50/mmol L−1 (R = 0.94), also their MlogPs with Minnow_LC
50/mg L−1 (R = 0.80 and R = 0.78), BCF (R = 0.86 and R = 0.82) and percentage of o-quinones’ yields (R = 0.73 and R = 0.80). Entactogens were predicted as non-biodegradable molecules, whereas the majority of their o-quinones were biodegradable.
Influence of flavonoids’ lipophilicity on platelet aggregation
Authors: Babić Ivana , Bojić Mirza , Maleš Željan , Zadro Renata , Gojčeta Koraljka , Duka Ivan , Rimac Hrvoje , Jukić Irena 
Published: October 2019

Abstract
Flavonoids are natural polyphenolic compounds present in a wide spectrum of plants that have a beneficial effect on human health. In the context of cardiovascular diseases related to plaque and thrombus formation, flavonoids exhibit an anti-aggregatory effect. Previously, it has been reported that all tested flavonoids exhibit an antiaggregatory effect on platelet aggregation when measured by impedance aggregometry on whole blood, in the test of aggregation induced by adenosine diphosphate (ADP). As not all flavonoids have the same targets within signaling pathways, an assumption of a common non-specific mechanism related to lipophilicity is to be considered. To test this hypothesis, reverse-phase thin layer chromatography was used to assess the lipophilicity of flavonoids; impedance aggregometry was used for testing of platelet aggregation and flow cytometry to monitor the influence of flavonoids on platelet activation. Lipophilicity analysis showed a highly negative correlation of logP and MINaAC for groups of flavones and flavanones. As determined by flow cytometry, the exposition of receptors necessary for the promotion of platelet activation and primary clot formation was diminished, i.e., lowered expression of the activated form of integrin αIIbβ3 was observed in the presence of flavanone. Platelet membrane stabilization by flavonoids as a mechanism of antiaggregatory effect has been supported by impedance aggregometry experiments when specific inhibitors of platelet aggregation signaling pathways (U73122, indomethacin, verapamil) were used in the presence of a weak (ADP) and a strong (TRAP-6) agonist of aggregation. While individual flavonoids can have specific targets within aggregation signaling pathways, all flavonoids share a common non-specific mechanism of platelet aggregation inhibition related to their lipophilicity and membrane stabilization that, to some extent, contributes to their antiaggregatory effect.
Antiproliferative evaluation of various aminoquinoline derivatives
Authors: Zorc Branka , Rajić Zrinka , Perković Ivana 
Published: October 2019

Abstract
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC
50 values in low micromolar range against all tested cancer cell lines.
Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres
Authors: Romić Marieta Duvnjak , Sušac Anja , Lovrić Jasmina , Cetina-Čižmek Biserka , Filipović-Grčić Jelena , Hafner Anita 
Published: October 2019

Abstract
The aim of this study was to evaluate long-term stability and assess the wound healing potential of the innovative melatonin-loaded lipid-enriched hybrid system compared to conventional melatonin-loaded chitosan microspheres. The hybrid system contained nanostructured lipid carrier incorporated in the chitosan matrix, in order to modify melatonin release and alter physicochemical characteristics of the delivery system. Stability testing was performed during a six-month period under two conditions: refrigerated (5 ± 3 °C) and at room temperature (25 ± 2 °C/60 ± 5 % RH). Samples stored at both conditions were analyzed in terms of particle size, zeta potential, moisture content and thermal properties. At the end of testing, drug content was determined in all samples. Dressings wound healing potential was assessed by in vitro scratch test using human skin fibroblast cell line. Although both systems showed good stability characteristics, the addition of lipids in the system has improved its wound healing potential.