bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do diverse cover crop mixtures perform better than monocultures? A systematic review
Authors: Florence A. M. , McGuire A. M. 
Published: June 2020

AbstractMulti‐species cover crop mixtures have been increasing in popularity. It has been hypothesized these mixtures produce more biomass, suppress more weeds, scavenge more N, conserve more soil water, stimulate more soil biology, promote higher yields of subsequent crops, and have higher production stability than the best of their monoculture counterparts. This systematic review synthesizes a growing body of cover crop mixture research to assess, for these metrics, whether cover crop mixtures can perform better than their constituent species when planted alone. Searching three databases, we identified 27 studies which compared cover crop mixtures (containing at least three species) to all their constituent species. The studies contained 119 sampled cover crop plantings that met our eligibility criteria. From these, we extracted 243 full comparisons of the best‐performing mixture and best‐performing monoculture for the selected metrics. In 88% of these comparisons, the monoculture and mixture performed comparably. In 10% of the comparisons, the monoculture did better, and in 2% of comparisons the mixture performed better. Overall, there are few published studies documenting the superiority of cover crop mixtures over monocultures for our selected metrics.
The β2‐Glycoprotein I/HLA–DR Complex As a Major Autoantibody Target in Obstetric Antiphospholipid Syndrome
Authors: Tanimura Kenji , Saito Shigeru , Nakatsuka Mikiya , Nagamatsu Takeshi , Fujii Tomoyuki , Fukui Atsushi , Deguchi Masashi , Sasagawa Yuki , Arase Noriko , Arase Hisashi , Yamada Hideto 
Published: June 2020

ObjectiveThe clinical manifestations of antiphospholipid syndrome (APS) include vascular thrombosis and pregnancy morbidity as well as recurrent pregnancy loss (RPL). However, in more than half of patients with RPL, the cause is never determined. Recently, β2‐glycoprotein I (β2GPI) complexed with HLA class II molecules (β2GPI/HLA‐DR) was found to be a major autoantibody target in APS. The present study was undertaken to assess the serum levels of autoantibodies against the β2GPI/HLA II complex as a potential risk factor for RPL in women.MethodsSerum levels of antiphospholipid antibodies (aPLs), including IgG/IgM anticardiolipin antibodies, IgG/IgM anti–β2GPI antibodies, and lupus anticoagulant as well as anti‐β2GPI/HLA–DR antibodies, were measured in 227 women with RPL. In this prospective, multicenter, cross‐sectional study, women with RPL and their partners underwent HLA–DR immunotyping and analysis to identify potential causes and risk factors associated with RPL. The normal range for anti‐β2GPI/HLA–DR antibody levels was determined using serum samples obtained from a control population of female subjects (208 women of childbearing potential).ResultsOf the 227 women with RPL, aPL antibodies were detected in 19.8%, and 52 (22.9%) tested positive for anti‐β2GPI/HLA–DR antibodies. Among the 227 women, 121 (53.3%) had no risk factors for RPL, and among these women with unexplained RPL, 24 (19.8%) were positive for anti‐β2GPI/HLA–DR antibodies. Of the 112 women who had clinical symptoms of APS but did not have levels of aPLs that met the diagnostic criteria for APS, 21 (18.8%) were positive for anti‐β2GPI/HLA–DR antibodies.ConclusionThe anti‐β2GPI/HLA–DR antibody is frequently associated with RPL. Detection of these autoantibodies is useful in understanding the pathogenesis of RPL. Our findings may provide potential new therapeutic strategies for addressing RPL in patients with obstetric APS.
Performance Characteristics of Pulmonary Function Tests for the Detection of Interstitial Lung Disease in Adults With Early Diffuse Cutaneous Systemic Sclerosis
Authors: Bernstein Elana J. , Jaafar Sara , Assassi Shervin , Domsic Robyn T. , Frech Tracy M. , Gordon Jessica K. , Broderick Rachel J. , Hant Faye N. , Hinchcliff Monique E. , Shah Ami A. , Shanmugam Victoria K. , Steen Virginia D. , Khanna Dinesh 
Published: June 2020

ObjectiveInterstitial lung disease (ILD) is the leading cause of death in patients with systemic sclerosis (SSc). Although pulmonary function tests (PFTs) are commonly used to screen for ILD in patients with SSc, studies have shown that they lack sensitivity for the detection of ILD in general SSc cohorts. This study was undertaken to assess the performance characteristics of PFTs for the detection of ILD in patients with early diffuse cutaneous SSc (dcSSc), a population at high risk for the development of ILD.MethodsWe performed a retrospective cohort study of patients enrolled in the Prospective Registry of Early Systemic Sclerosis at 11 sites in the US between April 2012 and January 2019. Patients were included if they underwent spirometry and high‐resolution computed tomography (HRCT) of the chest. We calculated the performance characteristics of PFTs for the detection of ILD on HRCT.ResultsThe study included 212 patients, 54% of whom had radiographic ILD. For the detection of ILD on HRCT imaging, a forced vital capacity (FVC) <80% predicted had a sensitivity of 63%. The combination of FVC <80% predicted or diffusing capacity for carbon monoxide (DLco) <80% predicted improved the sensitivity to 85%. An FVC <80% predicted had a negative predictive value (NPV) of 61%, while the combination of FVC <80% predicted or DLco <80% predicted had an NPV of 70%.ConclusionPFTs alone are an inadequate screening tool for the diagnosis of ILD in patients with early dcSSc. HRCT should be part of the ILD screening algorithm in patients with dcSSc.
The Effectiveness of an Augmented Reality Head‐Mounted Display in Learning Skull Anatomy at a Community College
Authors: Duncan‐Vaidya Elizabeth A. , Stevenson Erica L. 
Published: June 2020

Despite an increase in the use of technology in undergraduate anatomy education, and the rising popularity of online anatomy courses at community colleges in the United States, there have been no reports on the efficacy of augmented reality on anatomy education in this population. The purpose of this study was to test the hypothesis that augmented reality is an effective and engaging tool for learning anatomy in community college students. Participants recruited from Cuyahoga Community College (Cleveland, OH) studied skull anatomy using either traditional tools (i.e., textbook and plastic skull model) or an augmented reality head‐mounted display with an interactive virtual skull application. Comparison of knowledge before and following the study period revealed that augmented reality was an effective tool for learning skull anatomy: pre‐quiz = 32.7% (± 25.2); mean (± SD), post‐quiz = 61.8% (± 19.5); n = 15; t(28) = 3.53; P = 0.001. The traditional tools were equally effective: pre‐quiz = 44.9 % (± 18.6), post‐quiz = 67.9 % (± 17.3); n = 17; t(32) = 3.73; P = 0.0007. Students rated the augmented reality device as 9.6 (± 1.0); mean (± SD) when asked if it fit the statement “fun to use” on a semantic differential scale from 1 (poor) to 10 (excellent). In conclusion, this study found that augmented reality is an effective and engaging tool for the instruction of skull anatomy at a community college.
Review of life‐cycle greenhouse‐gas emissions assessments of hydroprocessed renewable fuel (HEFA) from oilseeds
Authors: Zemanek Debrah , Champagne Pascale , Mabee Warren 
Published: June 2020

AbstractRenewable fuel from the hydroprocessed esters and fatty acids (HEFA) pathway represents a promising short‐term option for reducing fossil fuel use in transportation. However, some life‐cycle assessments (LCAs) have shown that HEFA diesel and jet fuel may have higher life‐cycle greenhouse gas (GHG) emissions than the fossil fuels they replace. Many of these studies examined HEFA fuel derived from oilseed feedstocks. Here, results and methodology from 20 LCAs of HEFA fuel from oilseeds are reviewed in an effort to determine the sources of variability in the reported life‐cycle GHG emissions of HEFA fuels. Although there was a 61–63% reduction in median life cycle GHG emissions of HEFA biojet and renewable diesel compared to conventional petroleum fuels, this review highlights the importance of standardized methodologies for life‐cycle assessment (e.g., CORSIA, RSB) and indicates the need to prevent the conversion of forest land for biofuel production, as well as the potential opportunity for alternative oilseeds such as camelina and carinata as feedstocks to produce HEFA fuels with lower life‐cycle GHG emissions. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd
The effect of perceived financial vulnerability on prosocial activity
Authors: Motsenok Marina , Ritov Ilana 
Published: June 2020

AbstractOur research examines the effect of subjective financial vulnerability on prosocial activity. First, data from the European Survey of Health, Aging and Retirement (SHARE) revealed that higher assessment of one's financial vulnerability might be associated with prosocial motivation for social activities. Next, we manipulated participants' perception of their relative financial position compared to their peers and found that participants randomly assigned to the low financial position condition were more willing to volunteer than participants assigned to the high financial position condition. In Study 3, we manipulated participants' financial advantage. Participants who were disadvantaged in the experimental settings were more willing to volunteer and donate to charity compared to participants with financial advantage. In our final study, we examined willingness to donate to in‐group and out‐group help organizations and found that individuals of lower perceived financial standing may be motivated by the goal of increasing the strength of the social group, rather than by expectations of direct reciprocity. We also found that emotional distress mediates the relationship between perceived financial vulnerability and prosocial behavior. In line with earlier research illustrating that lower financial status promotes prosociality on an interpersonal level, we demonstrate that even momentary perception of relative financial disadvantage and vulnerability promotes prosociality in the broader social context.
Teaching now, facing the future
Authors: Lu Xiaoyun , Ding Yan 
Published: June 2020

AbstractTo obtain knowledge is not the purpose of education, but to develop one's potential ability and to obtain wisdom is. We are living in a fast changing world and knowledge is growing explosively. Therefore, what facts or information students have known in your class is not the most important thing. What really matters is how efficiently students could learn and how those knowledge they have learned can help them to deal with their own tasks in the future. This article introduces our four‐dimensional comprehensive course design and the teaching activities we used to optimize and improve students' learning and developing process.
Investigating the relationship between interleukin‐6 serum levels and outcome in acute ischemic CVA
Authors: Mosarrezaii Arash , Amiri‐Nikpour Mohammad Reza , Mehryar Hamid Reza , Choobi Anzali Babak , Nourooz‐Zadeh Sarmad , Babaei Shadi , Farrokhi Hedieh 
Published: June 2020

AbstractIntroductionInterleukin‐6 (IL‐6) is among the inflammatory mediators exhibiting elevated levels in ischemic stroke (IS) patients. The present study set out to evaluate the relationship between serum levels of interleukin‐6 with long‐term and at‐hospital outcomes of acute ischemic stroke in patients hospitalized at Imam Khomeini Hospital, Urmia, Iran, from 2017 to 2018.Method and materialsThis cross‐sectional descriptive study enrolled 29 and 31 acute stroke patients for long‐term and at‐hospital observation, respectively. Evaluation of stroke severity was performed using the National Institute of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) on days 1, 5, and 90. Serum IL‐6 level was measured via enzyme‐linked immunosorbent assay (ELISA) on days one and five.ResultsIn the present cohort study, the following population were enrolled: for long‐term evaluation, 11 (38%) men and 18 (63%) women with a mean age of 64.5 ± 14.9 years, and for at‐hospital evaluation: 11 (37.5%) men and 20 (64.5%) with a mean age of 65.25 ± 14.37 years. A significant positive correlation was observed between IL‐6 levels with NIHSS and mRS scores of the patients from time of admission until the end of the follow‐up period (long‐term: p < .001; at‐hospital: 0.022).ConclusionThe evidence from the present study suggests that IL‐6 contributes to the determination of the severity of ischemic strokes and may be useful in predicting prognosis. However, larger scale studies are required to further establish these finds.
Implementing the circular economy in the Amsterdam Metropolitan Area: The interplay between market actors mediated by transition brokers
Authors: Cramer Jacqueline M. 
Published: June 2020

AbstractThis paper analyses the interplay between regime and niche actors in implementing the circular economy through mediation by transition brokers. The study is based on ‘action research’ carried out in the Amsterdam Metropolitan Area. Innovation science is adopted as theoretical approach. First, the analysis shows that more ambitious initiatives could be taken than by individual market actors. Whether these circular initiatives represent just incremental change—as other studies suggest—cannot be concluded. Rather, it is plausible to conceptualise the transition process as a continuous transformational change. Second, in creating circular initiatives, the interplay between regime and niche actors was evident but varied. Actors could team up more easily where their interests aligned. This conclusion corresponds with recent innovation literature, which emphasises the importance of linkages between processes at niche, regime and landscape levels. Before generalising the results, similar studies in other regional contexts would be valuable.Short informative

In moving to a circular economy, the willingness of market actors to innovate is crucial.
Real‐life experiments on the implementation of circular initiatives built by market actors at local level through the mediation of independent intermediaries (here called ‘transition brokers’) are scarce. This study aims to bridge this knowledge gap by focussing on the interplay between niche and regime actors.
Action research on implementing the circular economy programme in the Amsterdam Metropolitan Area (2015–2020) represents an example.
Innovation science is adopted as leading theoretical approach.
The case shows that more advanced ambitions could be achieved than through individual market actors by themselves. Whether the circular initiatives built represent just incremental change—as suggested in the few other studies—is considered too simplistic. It is concluded to conceptualise the CE transition rather as a continuous, transformational change which takes time.
The interplay between niche and regime actors was evident in the case but varied. Niche actors could team up more easily with regime actors where their interests coincided. Niche CE innovations did not necessarily develop in protected environments, as suggested by early MLP studies. They could diffuse more widely if they link up with ongoing processes at regime and landscape level. This conclusion corresponds with the more recent innovation literature.
Longitudinal analysis of pediatric distal radius alignment parameters in a cohort of serial radiographs
Authors: Knapik Derrick M. , Kolaczko Jensen G. , Drummond Ian , Liu Raymond W. 
Published: June 2020

AbstractBackgroundGrowth in pediatric patients necessitates changes to bony structures throughout the entire body to suit development. Changes in the distal radius during growth are of interest in the pediatric population due to the high incidence of fractures. The purpose of this study was to assess for trends in three radiographic measurements (height of the radial styloid process, radial inclination, ulnar variance) of the distal radius using serial radiographs in subjects aged between 6 and 14 years of age.Materials and MethodsLongitudinal radiographs from 68 healthy children (n = 34 males, 34 females) with a minimal of three annual radiographs between 6 and 14 years of age were analyzed. Measurements of height of the radial styloid process, radial inclination, and ulnar variance were performed in each available radiograph. Repeated measures analysis of variance (ANOVA) was performed to measure the association between alignment values and subject age.ResultsA total of 436 images in 68 subjects were analyzed, comprising a mean of 6.5 ± 2.0 radiographs per subject. Repeated measures ANOVA demonstrated that all measurement variables changed significantly with age (p < .001). Ulnar variance demonstrated the most variability with negative ulnar variance in younger children, and trends towards a more neutral ulnar variance by approximately 7 years in females and 11 years in males, while height of the radial styloid process and radial inclination changed relatively minimally with development.ConclusionsIn the adolescent age range, ulnar variance, height of the radial styloid process and inclination are all relatively stable and adult parameter values can be used to judge restoration of distal radius alignment.
Trabecular bone deterioration in differentiated thyroid cancer: Impact of long‐term TSH suppressive therapy
Authors: Hawkins Carranza Federico , Guadalix Iglesias Sonsoles , Luisa De Mingo Domínguez María , Martín‐Arriscado Arroba Cristina , López Álvarez Begoña , Allo Miguel Gonzalo , Martínez Díaz‐Guerra Guillermo 
Published: June 2020

AbstractBackgroundConflicting results has been reported regard osteoporosis and fractures in patients with Differentiated Thyroid Cancer (DTC). Our objective was to evaluate the long‐term effects of TSH suppression therapy with Levothyroxine (LT4) on trabecular bone score (TBS) and bone mineral density (BMD) in females with DTC after thyroidectomy.MethodsAbout 145 women with resected DTC and receiving long‐term TSH therapy, were stratified according to the degree of TSH suppression. Mean duration of follow‐up was 12.3 ± 6.1 years. BMD and TBS, were assessed using dual‐energy X‐ray absorptiometry (DXA) and TBS iNsight (Med‐Imaps), at baseline (1‐3 months after surgery) and at the final study visit.ResultsIn patients stratified by duration of TSH suppression therapy (Group I, 5‐10 years; Group II, >10 years), slight increases from baseline TSH levels were observed. Significant decreases in LS‐BMD and FN‐BMD were seen in patients after >10 years. TBS values were lower in Groups I (1.289 ± 0.122) and II (1.259 ± 0.129) compared with baseline values (P = .0001, both groups). Regarding the degree of TSH suppression, TBS was significantly reduced in those with TSH < 0.1 µU/mL (P = .0086), and not in patients with TSH suppression of 0.1.‐0.5 or >0.5 µU/mL.ConclusionsWe found deterioration of trabecular structure in patients with DTC and TSH suppression therapy below 0.1 µU/mL and after 5‐10 years of follow‐up. Significant changes in BMD according to TSH levels were not observed. Trabecular Bone Score is a useful technique for identifying thyroid cancer patients with risk of bone deterioration.
Synthesis of Novel Aryloxyethylamine Derivatives and Evaluation of Their in Vitro and in Vivo Neuroprotective Activities
Authors: Zhong Yan , Gao Yarong , Xu Yi , Qi Changyong , Wu Bin 
Published: June 2020

AbstractA series of aryloxyethylamine derivatives were designed, synthesized and evaluated for their biological activity. Their structures were confirmed by 1H‐NMR, 13C‐NMR, FT‐IR and HR‐ESI‐MS. The preliminary screening of neuroprotection of compounds in vitro was detected by MTT, and the anti‐ischemic activity in vivo was tested using bilateral common carotid artery occlusion in mice. Most of these compounds showed potential neuroprotective effects against the glutamate‐induced cell death in differentiated rat pheochromocytoma cells (PC12 cells), especially for (4‐fluorophenyl){1‐[2‐(4‐methoxyphenoxy)ethyl]piperidin‐4‐yl}methanone, {1‐[2‐(4‐methoxyphenoxy)ethyl]piperidin‐4‐yl}(4‐methoxyphenyl)methanone, (4‐bromophenyl){1‐[2‐(4‐methoxyphenoxy)ethyl]piperidin‐4‐yl}methanone, {1‐[2‐(4‐chlorophenoxy)ethyl]piperidin‐4‐yl}(4‐chlorophenyl)methanone, (4‐chlorophenyl)(1‐{2‐[(naphthalen‐2‐yl)oxy]ethyl}piperidin‐4‐yl)methanone, (4‐chlorophenyl){1‐[2‐(4‐methoxyphenoxy)ethyl]piperidin‐4‐yl}methanone and {1‐[2‐(4‐bromophenoxy)ethyl]piperidin‐4‐yl}(4‐chlorophenyl)methanone, which exhibited potent protection of PC12 cells at three doses (0.1, 1.0, 10 μM). Compounds (4‐fluorophenyl){1‐[2‐(4‐methoxyphenoxy)ethyl]piperidin‐4‐yl}methanone, (4‐fluorophenyl){1‐[2‐(naphthalen‐2‐yloxy)ethyl]piperidin‐4‐yl}methanone, {1‐[2‐(4‐methoxyphenoxy)ethyl]piperidin‐4‐yl}(4‐methoxyphenyl)methanone and {1‐[2‐(4‐chlorophenoxy)ethyl]piperidin‐4‐yl}(4‐chlorophenyl)methanone possessed the significant prolongation of the survival time of mice subjected to acute cerebral ischemia and decreased the mortality rate at all five doses tested (200, 100, 50, 25, 12.5 mg/kg) and had significant neuroprotective activity. In addition, (4‐fluorophenyl){1‐[2‐(4‐methoxyphenoxy)ethyl]piperidin‐4‐yl}methanone, {1‐[2‐(4‐methoxyphenoxy)ethyl]piperidin‐4‐yl}(4‐methoxyphenyl)methanone and {1‐[2‐(4‐chlorophenoxy)ethyl]piperidin‐4‐yl}(4‐chlorophenyl)methanone possessed outstanding neuroprotection in vitro and in vivo. These compounds can be used as a promising neuroprotective agents for future development of new anti‐ischemic stroke agents. Basic structure–activity relationships are also presented.
NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL‐6/JAK2/STAT3 pathway activation
Authors: Kang Jian‐Hua , Li Ming‐Jie , Luan Pei‐Pei , Jiang De‐Ke , Chen Yuan‐Wen , Xu Xu , Yu Qing , Xu Ya‐Wei , Su Qing , Peng Wen‐Hui , Jian Wei‐Xia 
Published: June 2020

AbstractNucleotide‐binding domain, leucine‐rich repeat family with a caspase activation and recruitment domain 3 (NLRC3) participates in both immunity and cancer. The aim of this study was to determine the role of NLRC3 in human hepatocellular carcinoma (HCC) and the underlying mechanisms. We collected human liver tissues from nonalcoholic steatohepatitis (NASH), HCC, and adjacent normal tissues to characterize the pattern of NLRC3 expression by real‐time quantitative polymerase chain reaction and immunohistochemistry. Then, we used the HCC cell line, HuH‐7, transfected with small interfering RNA to silence the NLRC3 expression. 5‐Ethynyl‐2'‐deoxyuridine assay, scratch assay, and transwell invasion assay were used for assessing proliferation, migration, and invasion, respectively. Flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay were conducted to assess cell apoptosis. The expression of NLRC3 was reduced in human HCC tissues, compared with normal liver and nonalcoholic steatohepatitis tissues. After knocking down of NLRC3, the proliferation, migration, and invasion were increased in HuH‐7 cells. And flow cytometry and TUNEL assay showed that HuH‐7 cell apoptosis was suppressed after NLRC3 knockdown. As for the underlying mechanisms, knockdown of NLRC3 in HuH‐7 cells was associated with the activation of Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway under interleukin‐6 (IL‐6) stimulation. NLRC3 expression was downregulated in human HCC tissues. NLRC3 silencing in HuH‐7 cells can promote the proliferation, migration, and invasion of hepatocellular carcinoma cells. JAK2/STAT3 pathway activation induced by IL‐6 may be the underlying mechanism for HCC when NLRC3 expression is silenced. And the invasion of HuH‐7 cells was partially suppressed by the STAT3 specific inhibitor (cryptotanshinone). Therefore, NLRC3 may play a significant role in HCC and might be a therapeutic target for the treatment of HCC.