bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in stakeholders self-organising to enhance disaster communication
Authors: Le Roux Tanya , Van Niekerk Dewald 
Published: November 2019

Purpose
The purpose of this paper is to combine disaster risk reduction (DRR) and communication management literature to investigate the challenges and opportunities encountered when stakeholders spontaneously self-organise communication efforts during a disaster. The 2017 Knysna Fire Disaster in South Africa is used as the context.

Design/methodology/approach
The qualitative, exploratory research was supported by data obtained through thematic analysis of qualitative in-depth interviews and the Facebook page created by the community. Information from the disaster debrief was also included.

Findings
The findings suggest that disaster information needs to be sent every 30 s to a minute to coordinate rescue and relief efforts. The challenges for disaster management teams to manage this mammoth task and the role that the self-organising community played in assisting the communication process was found not to be recognised in disaster management policies or systems. This adversely affected the work of the disaster management team and stakeholder relationship.

Research limitations/implications
This study focussed on one disaster. Future studies could possibly compare various disaster examples to provide even greater insight into the self-organising communicative behaviour of those affected by disasters.

Originality/value
The research gives one of the first clear indications of the scope of disaster communication needed during a disaster. It also highlights the community’s ability to contribute to communication management during a disaster, and which is not catered for in the practice, guidelines or management systems used for disaster management.
Study of the influence of assemblies on knitted materials hand
Authors: Daukantienė Virginija , Mikalauskaitė Gerda 
Published: November 2019

Purpose
The purpose of this paper is to evaluate the influence of assembly type on the hand property of the polyester-knitted materials containing different amounts of elastane fibre.

Design/methodology/approach
The hand property of control textile materials specimens as well as assembled ones applying both adhesive bonding and sewing was evaluated analysing the typical pulling curves as well as the individual hand parameters, which were determined using the device KTU-Griff-Tester. The complex hand criterion Q was calculated for the complete assessment of both textiles and their assemblies’ hand by one numeral value.

Findings
It was shown that the fabric structure and assembly type have a significant influence on the knitted materials hand property. The complex hand criterion Q varied from 0.068 to 0.186, depending on the material structure, and it was decreased up to 42.6 per cent due to textile assemblies.

Practical implications
The determined research results are significant not only for clothing science but also leads to the improvement in clothing quality in fashion industry suggesting more ergonomic and original constructional decisions for clothes’ design, selection of most suitable assembly type and its place in overall garment area, which is very important for the development process of the slim fitted sportswear featuring with a very complicated construction, usually worn under intensive body movements causing rubbing effect to the skin.

Originality/value
Knitted fabrics should not only be elastic but also have perfect hand, thus making them to feel comfortable. But hand property of assembled textiles had not been investigated previously. Novelty and originality of this research was the objective and simple evaluation of the hand property for both knitted materials and their assemblies taking into account the overall skin sensorial comfort of a garment.
Achieving productive reliability through applying statistical distribution functions
Authors: Karbasian Mahdi , Rostamkhani Ramin 
Published: November 2019

Purpose
The purpose of this paper is to find the proper statistical distribution function, which can cover the failure time of a single machine or a group of machines. To this end, an innovative program is written in an Excel software, capable of assessing at least six statistical distribution functions. This research study intends to show the advantages of applying statistical distribution functions in an integrated model format to create or increase productive reliability machines. Productive reliability is a simultaneous combination of efficiency and effectiveness in reliability.

Design/methodology/approach
The method of theoretical research methodology comprises data collection tools, reference books and articles in addition to exploiting written reports of the Iranian Center for Defence’s Standards. The practical research method includes deploying and assessing the proposed model for a selected machine (in this case a computerized numerical control machine).

Findings
A comprehensive program in an Excel software having the capability of assessing at least six statistical distribution functions was developed to find the most efficient option for covering the failure times of each machine in the shortest time with the highest precision. This is regarded as the most important achievement of the present study. Furthermore, the advantages of applying the developed model are discussed and a large group of which have direct influences on the productivity of equipment reliability.

Originality/value
The originality of the research was ascertained by managers and experts working in maintenance issues at the different levels of the Defense Industries Organization.
The impact of brand experience on the memory formation
Authors: Legendre Tiffany S. , Cartier Elizabeth A. , Warnick Rodney B. 
Published: November 2019

Purpose
The purpose of this paper is to examine the effectiveness of brand experiences on visitors’ memory formation and their revisit intention to a special event.

Design/methodology/approach
This study collected survey data from the Great New England Air Show to examine the soundness of the proposed theoretical model. Data were analyzed with partial least squares–structural equation modeling.

Findings
The results indicate an individual’s brand experience in the context of a special event can assist him/her in becoming more involved and finding meaningfulness in the experience, and form greater readiness to store memory of the event. Memory formation triggered by brand experience can help event practitioners anticipate positive behaviors of visitors after the experience.

Practical implications
The results suggest that event marketing managers and decision makers should create strong brand experiences focused on a mix of sensory, affective, intellectual and behavioral messages linked to the larger brand knowledge and memory formation.

Originality/value
The development of a theoretical model explaining brand experience with the purpose of explaining the internalization of brand experience in memory formation was documented and the study validated the brand experience concept in a non-monetary setting.
Update on recommendations for eligibility of government subsidization of biologic disease‐modifying antirheumatic drugs for the treatment of axial spondyloarthritis in Singapore
Authors: Phang Kee Fong , Lahiri Manjari , Fong Warren Weng Seng , Leong Keng Hong , Leung Ying Ying , Lim Anita Yee Nah , Lui Nai Lee , Manghani Mona , Tan Teck Choon , Santosa Amelia , Sriranganathan Melonie Kannamma , Suresh Ernest , Teng Gim Gee , Cheung Peter P. 
Published: November 2019

AbstractAimsThe field of axial spondyloarthritis (axSpA) has undergone significant changes recently in particular with disease classification, assessment of disease activity and increased treatment options for biologics. In order to reflect these developments, we aimed to update the local consensus recommendations for subsidization of biologics.MethodsA modified Delphi approach was used. Six published guidelines from major rheumatology societies and healthcare authorities on axSpA were reviewed. Findings were synthesized and used in formulating updated recommendation statements. Recommendations were rated by 10 practicing rheumatologists in Singapore. Consensus was reached if there was more than 70% agreement or disagreement.ResultsTen statements achieved consensus. Patients may be considered for subsidization of biologic therapy if they fulfill the Assessment of Spondyloarthritis International Society or modified New York criteria, with persistently active disease (defined either by Ankylosing Spondylitis Disease Activity Score ≥ 2.1 or Bath Spondylitis Disease Activity Index ≥ 4), despite 4 weeks of full‐dose non‐steroidal anti‐inflammatory drugs and regular exercise. Either tumor necrosis factor inhibitors or interleukin 17 inhibitors may be used as first‐line therapy, and should be continued if adequate response is achieved at 6 months.ConclusionRecommendation statements were formulated through a formal consensus process by local experts with a view to assist relevant authorities in funding considerations and for use in clinical practice.
Identifying damage clusters in patients with systemic lupus erythematosus
Authors: Ahn Ga Young , Lee Jiyoung , Won Soyoung , Ha Eunji , Kim Hyoungyoung , Nam Bora , Kim Ji Soong , Kang Juyeon , Kim Jae‐Hoon , Song Gwan Gyu , Kim Kwangwoo , Bae Sang‐Cheol 
Published: November 2019

AbstractAimSystemic lupus erythematosus (SLE) causes irreversible damage to organ systems. Recently, evidence has been obtained for subphenotypes of SLE. This study aimed to identify damage clusters and compare the associated clinical manifestations, SLE disease activity, mortality, and genetic risk scores (GRS).MethodsThe study was conducted on the Hanyang BAE lupus cohort. Patients with disease duration <5 years were excluded to minimize confounding effects of disease duration. They were grouped into 3 clusters based on the Systemic Lupus International Collaborating Clinics Damage Index using k‐means cluster analysis.ResultsAmong the 1130 analyzed patients, musculoskeletal damage was most prevalent (20.2%), followed by ocular (11.4%), renal (10.5%), and neuropsychiatric damage (10.2%). Three significantly different damage clusters were identified. Patients in cluster 1 (n = 824) showed the least damage. Cluster 2 (n = 195) was characterized by frequent renal (55.4%) and ocular (58.0%) damage, and cluster 3 (n = 111) was dominated by neuropsychiatric (100%) and musculoskeletal damage (35.1%). Cluster 2 had the highest adjusted mean AMS (adjusted mean SLE Disease Activity Index score; mean ± SD: 5.4 ± 2.9), while cluster 3 had the highest mortality (14.4%). Weighted GRS did not differ significantly between the clusters.ConclusionPatients in prevalent renal and ocular damage cluster had the highest AMS scores, while the cluster with frequent neuropsychiatric damage had the highest mortality.
Singapore chapter of rheumatologists' updated consensus statement on the eligibility for government subsidization of biologic and targeted therapy for the treatment of psoriatic arthritis
Authors: Chua Cheryl K. T. , Teng Gim Gee , Cheung Peter P. , Fong Warren Weng Seng , Leong Keng Hong , Leung Ying Ying , Lim Anita Y. N. , Lui Nai Lee , Manghani Mona , Santosa Amelia , Sriranganathan Melonie Kannamma , Suresh Ernest , Tan Teck Choon , Lahiri Manjari 
Published: November 2019

AbstractAimThere have been major advances in biologic treatment options for psoriatic arthritis (PsA) since the publication of the 2015 consensus recommendations by the Chapter of Rheumatologists, College of Physicians, Academy of Medicine, Singapore, for government‐assisted funding, thus warranting a revision of this guideline.MethodsRecent trials and nine published guidelines on the use of biologic therapy for PsA were reviewed. Based on the synthesized evidence, a task force panel (TFP), consisting of 10 practicing rheumatologists in Singapore, rated the statements pertaining to the use of biologic therapy, using a modified Delphi approach. Consensus was obtained if >70% agreed on a statement.ResultsThe TFP agreed on 10 recommendations pertaining to the initiation, choice and continuation of biologic therapy. A biologic is indicated in patients with PsA: (a) with at least three swollen and tender joints, digits or entheses; and (b) who have failed at least two conventional synthetic disease‐modifying anti‐rheumatic drug (csDMARD) strategies for a minimum of 3 months each. Any approved drug class including tumor necrosis factor inhibitors, interleukin‐17 inhibitors (IL‐17i), IL‐12/23i or targeted synthetic DMARDs may be considered as first‐line treatment, and continued only if a response is achieved by 6 months.ConclusionThese recommendations developed through a formal consensus method may be useful to guide funding considerations for appropriate and equitable use of biologic therapy for eligible patients with PsA.
Peripheral neuropathies in rheumatic diseases: More diverse and frequent than expected. A cross‐sectional study
Authors: López‐López Carlos Omar , Montes Castillo Maria de la Luz , Soto‐Fajardo Rosa Carina , Sandoval‐García León Felipe , Loyola‐Sánchez Adalberto , Burgos‐Vargas Rubén , Peláez‐Ballestas Ingris , Álvarez Hernández Everardo , Vázquez‐Mellado Janitzia 
Published: November 2019

AbstractBackground/objectivePeripheral neuropathies (PN) are heterogeneous nerve disorders; frequently rheumatic patients have neuropathic symptoms. In some rheumatic diseases (RD) PN are secondary to nerve compression while others are related to metabolic abnormalities, inflammation or vasculitis. Our aim was to explore the frequency of neuropathic symptoms with three neuropathy questionnaires (NQ) and nerve conduction studies (NCS) in RD.MethodsThis is a cross‐sectional study in patients with any RD attending for the first time to a rheumatology outpatient clinic. We included all patients who accepted to participate and who answered three NQ and received a physical evaluation. Twenty patients were randomly selected to perform NCS and 10 healthy subjects were included as controls. The topographic diagnoses were: mononeuropathy, multiplex mononeuropathy, and/or polyneuropathy. Statistical analysis: descriptive statistics (mean, median, standard deviation, interquartile range and frequency, odds ratios and Pearson correlation test).ResultsOne hundred patients and 10 healthy subjects were included. Sixty‐nine were female, mean age 40.6 ± 15.7 years. Rheumatic diagnoses were: systemic lupus erythematosus (26%), rheumatoid arthritis (16%), gout (14%), and osteoarthritis (11%). Fifty‐two patients had neuropathic signs during physical examination and 67% had positive questionnaires with variable scores among several RD. Abnormal NCS was reported in 14 patients (70%): 6 (42.8%) median nerve mononeuropathies, 4 (28.5%) multiplex mononeuropathies and 4 (28.5%) polyneuropathies. None of the healthy subjects had neuropathy (NQ, physical evaluation, or NCS). Risk of being NCS positive is higher when the patients were NQ positive.ConclusionPN has variable distribution and high frequency in patients with RD; NQ+ increases the risk of presenting NCS+ for PN.
MiR‐563 restrains cell proliferation via targeting LIN28B in human lung cancer
Authors: Zhang Xuefei , Li Mo , Sun Ge , Bai Yu , Lv Desheng , Liu Changhong 
Published: November 2019

BackgroundPrevious investigations have revealed that miR‐563 is associated with a number of diseases including the ossification of posterior longitudinal ligament, Parkinson's disease or drug resistance to leukemia. Yet, the role of miR‐563 and its molecular mechanism in the initiation and progression of cancers has not been previously explored. In this study, we aimed to provide clues to the function of miR‐563 and its direct target in lung cancer.MethodsOnline informatics software was applied to predict the target genes of miR‐563. MiR‐563 targeting LIN28B was evaluated through the luciferase reporter gene analysis. The effect of miR‐563 on LIN28B at the level of RNA and protein was detected using RT‐PCR and immunoblotting. The ability of proliferation of human lung cancer A549 was examined by MTT assay. RNA interference targeting LIN28B was examined through immunoblotting. The level of miR‐563 and LIN28B and their correlation were analyzed in 27 cases of lung tumor tissues by real‐time PCR.ResultsOncogenic LIN28B was identified as one of the target genes of miR‐563 in lung cancer cells. MiR‐563 dose‐dependently decreased the LIN28B RNA level and subsequently its protein level in the cells. Cell proliferation was suppressed by ectopic miR‐563 expression and was accelerated after endogenous miR‐563 was knocked down by its inhibitor. However, silence in LIN28B reversed promotion of cell proliferation by the inhibition of miR‐563. In lung cancer tissues, miR‐563 was decreased and negative correlation of miR‐563 and LIN28B was shown.ConclusionMiR‐563 plays a tumor suppressive role in lung cancer progression via targeting oncogenic LIN28B.
A cohort of transperineal electromagnetically tracked magnetic resonance imaging/ultrasonography fusion‐guided biopsy: assessing the impact of inter‐reader variability on cancer detection
Authors: Wajswol Ethan , Winoker Jared S. , Anastos Harry , Falagario Ugo , Okhawere Kennedy , Martini Alberto , Treacy Patrick‐Julien , Voutsinas Nicholas , Knauer Cynthia J , Sfakianos John P. , Lewis Sara C. , Taouli Bachir A. , Rastinehad Ardeshir R. 
Published: November 2019

ObjectiveTo evaluate the ability to detect clinically significant prostate cancer (PCa) using a novel electromagnetically (EM) tracked transperineal magnetic resonance imaging (MRI)/ultrasonography (US) fusion‐guided targeted biopsy (transperineal TBx) platform and the impact of inter‐reader variability on cancer detection.Materials and MethodsA total of 176 patients with suspicious lesions detected on multiparametric MRI (mpMRI) underwent a systematic modified Barzel template biopsy (12‐core) transperineal biopsy (transperineal SBx) and transperineal TBx with EM tracking (UroNav; Philips Healthcare, Best, the Netherlands) in the same setting. Cancer detection rates (CDRs) were stratified by Prostate Imaging Reporting and Data System (PI‐RADS) v2 scores and compared with Fisher’s exact test. Area under the curve (AUC) was calculated for prostate‐specific antigen (PSA), PSA density (PSAD), PI‐RADS score, and subgroup analysis of individual readers' PI‐RADS scores with respect to overall CDR and clinically significant CDR.ResultsThe overall CDR was 76.7% (135/176), of which 76.3% (103/135) was clinically significant PCa. Among the 135 patients with PCa, transperineal TBx detected 90.4% of cases (122/135), either alone or in combination with transperineal SBx. The remaining 9.6% of cases (13/135) missed by transperineal TBx were diagnosed by transperineal SBx alone, of which three were clinically significant. Conversely, transperineal SBx missed 14% of cases (19/135), 14 of which were clinically significant PCa. Sensitivities for transperineal TBx and transperineal SBx were 90.4% and 85.9%, respectively. On a per‐lesion basis, PI‐RADS score (AUC 0.74) outperformed both PSA (AUC 0.59) and PSAD (AUC 0.63) in discriminating clinically significant from non‐clinically significant PCa on transperineal TBx. Although not formally statistically tested, AUCs amongst different mpMRI readers appeared to display considerable variability. There were no adverse events, including sepsis.ConclusionsElectromagnetically tracked transperineal TBx of MRI‐visible lesions enhanced the ability of transperineal SBx to detect PCa, with greater sensitivity for clinically significant disease. These findings suggest transperineal TBx is a safe, alternative fusion platform for patients with a suspicious lesion on prostate MRI. The assessment of inter‐reader variability, in conjunction with prediction of clinically significant PCa and CDR, is an important first step for quality control in implementing an MRI‐based screening programme.
Identification of novel variants in the FZD4 gene associated with familial exudative vitreoretinopathy in Chinese families
Authors: Xu Huijuan , Zhang Shanshan , Huang Lulin , Zhao Peiquan , Zhang Xiang , Yang Zhenglin , Zhang Lin 
Published: November 2019

AbstractBackgroundFamilial exudative vitreoretinopathy (FEVR, OMIM 133780) is a severe hereditary retinal disease characterized by incomplete retinal vascular development and pathological neovascularization. It has been reported that variants in nine genes are associated with FEVR, but they can only explain approximately 50% of FEVR patients, suggesting that other FEVR‐associated variants or genes remain to be discovered.MethodsWhole‐exome sequencing (WES) was carried out to analyse genomic DNA samples from the probands of 68 families with FEVR. Sanger sequencing was used to verify all identified variants. Western blot analysis was utilized to detect the expression of the variant mutant proteins. A luciferase assay was conducted to test the receptor activity of the mutant FZD4 proteins in Norrin‐β‐catenin signaling.ResultsSeven heterozygous FZD4 variants were found to cause FEVR in seven families, including six missense variants and one deletion variant: c.182C>T (p.T61I), c.205C>T (p.H69Y), c.217_234del (p.73T_78Qdel), c.264C>A (p.Y88X), c.344G>T (p.G115V), c.678G>A (p.W226X) and c.1310T>C (p.I437T). Among these variants, c.205C>T (p.H69Y) and c.678G>A (p.W226X) are known FEVR‐causing variants, while the other five variants are novel pathogenic variants.ConclusionOur study revealed the cause of FEVR in seven Chinese families and identified five novel pathogenic variants in FZD4, which expanded the mutation spectrum of FEVR in the Chinese population. These findings also provided further support for using WES in the clinical diagnosis of FEVR.
Management of apnea in infants with trisomy 18
Authors: Taira Ryoji , Inoue Hirosuke , Sawano Toru , Fujiyoshi Junko , Ichimiya Yuko , Torio Michiko , Sanefuji Masafumi , Ochiai Masayuki , Sakai Yasunari , Ohga Shouichi 
Published: November 2019

This case series aimed to characterize the clinical features, management, and outcomes of apnea in infants with trisomy 18. Participants in this study were infants with trisomy 18 who were born alive and admitted to the neonatal intensive care unit in Kyushu University Hospital from 2000 to 2018. Retrospective analysis was performed on clinical data recorded in our department. Twenty‐seven infants with trisomy 18 were admitted to our hospital during the study period, of which 25 (nine males, 16 females) were enrolled as eligible participants in this study. Among them, 14 started presenting with apnea from median 3.5 days of age (range 0–47d). In these infants with apnea, eight received respiratory support of positive pressure ventilation (PPV). The 1‐year survival rate of infants in the PPV group was higher than that of non‐PPV‐supported infants (5 out of 8 vs 0 out of 6 infants). Five PPV‐supported infants received a diagnosis of epilepsy, which was controlled by antiepileptic drugs. Postnatal respiratory intervention provides better prognosis in infants with trisomy 18. Improved survival leads to accurate diagnosis and treatment of apneic events in association with epilepsy.What this paper adds

Respiratory support is effective against apnea in infants with trisomy 18.

Intervention with ventilation provides a higher chance of prolonged survival.

Improved survival leads to the accurate diagnosis and treatment of epilepsy‐associated apnea.