bluuebunny/crossref_metadata_2025_split huggingface dataset:
How can we interpret SARS-CoV-2 antibody test results?
Authors: Føns Sofie , Krogfelt Karen A 
Published: November 2020

ABSTRACTSince the outbreak of COVID-19, the world has raced to understand and accurately diagnose infection caused by SARS-CoV-2. Today, hundreds of commercial antibody tests are on the market despite often lacking proper validation and with unsatisfactory sensitivity and/or specificity. In addition, many questions related to the humoral response remain unresolved, although research is carried out at an unprecedented speed. Despite the shortcomings, serological assays have an important part to play in combating the pandemic by aiding in diagnosis and sero-epidemiological studies. However, careful attention must be paid to the application of serology and the interpretation of serological data—especially in low prevalence regions, both at an individual and at a population level. In this article, we argue that serological results are often misinterpreted, and in the eagerness to be first, methodological rigor is often taking a backseat.
How workers respond to social rewards: evidence from community health workers in Uganda
Authors: Chowdhury Reajul , McKague Kevin , Krause Heather 
Published: November 2020

AbstractThis paper investigates the effect of a non-financial incentive—a competitive annual award—on community health workers’ (CHWs) performance, an issue in the public health literature that has not been explored to its potential. Combining data on a competitive social ‘Best CHW’ award with the monthly performance of 4050 CHWs across Uganda, we examined if introducing social recognition awards improved the performance of CHWs. In contrast to predominant explanations about the effect of awards on motivation, our first multilevel mixed-effect models found that an award within a branch (consisting of ∼30 CHWs) was negatively associated with the performance of the local peers of the winning CHW. Models focused on non-winning branch offices revealed two additional findings. First, a branch showed underperformance if a CHW from any of the three neighbouring branches won an award in the previous year, with average monthly performance scores dropping by 27 percentage points. Second, this negative association was seen only in the top 50th percentile of CHWs. The bottom 50th percentile of CHWs exhibited increased performance by 13 percentage points. These counter-intuitive results suggest that the negative response from high performers might be explained by their frustration of not winning the award or by emotions such as envy and jealousy generated by negative social comparisons. Our results suggest that more fine-grained examination of data pertaining to motivators for CHWs in low-income countries is needed. Motivational incentives like awards may need to be customized for higher- and lower-performing CHWs.
Utilization of an Electronic Medical Record–integrated Dashboard Improves Identification and Treatment of Anemia and Iron Deficiency in Pediatric Inflammatory Bowel Disease
Authors: Breton Jessica , Witmer Char M , Zhang Yuchen , Downing Maura , Stevenson Jamie , McDermott Janine , Siddique Shazia M , Grossman Andrew B 
Published: November 2020

Abstract

Background
Iron deficiency (ID) and anemia are one of the most common extraintestinal manifestations of inflammatory bowel disease (IBD), usually complicating the course both in ulcerative colitis and Crohn’s disease. Despite their high prevalence and significant impact on patients, this particular aspect is still underestimated by clinicians. Although guidelines have been recently published to address this problem, these recommendations do not address pediatric specific concerns and do not provide guidance as to how implement these guidelines in clinical practice. The aims of this quality improvement (QI) initiative were to improve the rates of detection and treatment of anemia in children with IBD.

Methods
After the creation of a multidisciplinary team of skateholders in IBD and anemia, we launched a multifaceted QI strategy that included the development of a pediatric evidence-based care pathway, utilization of an electronic medical record (EMR)-integrated dashboard to track patients, and generation of an automated provider-based monthly report. Data were collected and graphed into statistical process control charts.

Results
These key strategies resulted in improved rates of ID screening from 31.7% to 63.6%, in increased treatment rates from 38.2% to 49.9%, and in decreased prevalence of anemia from 35.8% to 29.7%, which was reflected by a greater decline in patients with quiescent disease.

Conclusions
Quality improvement strategies incorporating the creation of a pediatric evidence-based care pathway with an EMR-supported electronic dashboard were the foundation of a successful intervention in the management of ID and anemia in pediatric IBD. Our positive results demonstrate the potential of QI initiatives using automated technology to assist clinicians in their commitment to provide evidence-based IBD care and enhance patient outcomes.
The Impact of Vedolizumab on Pre-Existing Extraintestinal Manifestations of Inflammatory Bowel Disease: A Multicenter Study
Authors: Ramos Guilherme Piovezani , Dimopoulos Christina , McDonald Nicholas M , Janssens Laurens P , Hung Kenneth W , Proctor Deborah , Ruggiero Elizabeth , Kane Sunanda , Bruining David H , Faubion William A , Raffals Laura E , Loftus Edward V , Al-Bawardy Badr 
Published: November 2020

Abstract

Background
There are limited data on how vedolizumab (VDZ) impacts extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD). The aim of this study was to determine the clinical outcomes of EIMs after initiation of VDZ for patients with IBD.

Methods
A multicenter retrospective study of patients with IBD who received at least 1 dose of VDZ between January 1, 2014 and August 1, 2019 was conducted. The primary outcome was the rate of worsening EIMs after VDZ. Secondary outcomes were factors associated with worsening EIMs and peripheral arthritis (PA) specifically after VDZ.

Results
A total of 201 patients with IBD (72.6% with Crohn disease; median age 38.4 years (interquartile range, 29-52.4 years); 62.2% female) with EIMs before VDZ treatment were included. The most common type of EIM before VDZ was peripheral arthritis (PA) (68.2%). Worsening of EIMs after VDZ occurred in 34.8% of patients. There were no statistically significant differences between the worsened EIM (n = 70) and the stable EIM (n = 131) groups in term of age, IBD subtype, or previous and current medical therapy. We found that PA was significantly more common in the worsening EIM group (84.3% vs 59.6%; P &lt; 0.01). Worsening of EIMs was associated with a higher rate of discontinuation of VDZ during study follow-up when compared with the stable EIM group (61.4% vs 44%; P = 0.02). Treatment using VDZ was discontinued specifically because of EIMs in 9.5% of patients.

Conclusions
Almost one-third of patients had worsening EIMs after VDZ, which resulted in VDZ discontinuation in approximately 10% of patients. Previous biologic use or concurrent immunosuppressant or corticosteroid therapy did not predict EIM course after VDZ.
Elliptic Fibrations and Kodaira Dimensions of Schreieder’s Varieties
Authors: Garbagnati Alice 
Published: November 2020

Abstract
We discuss the birational geometry and the Kodaira dimension of certain varieties previously constructed by Schreieder, proving that in any dimension they admit an elliptic fibration and they are not of general type. The $l$-dimensional variety $Y_{(n)}^{(l)}$, which is the quotient of the product of a certain curve $C_{(n)}$ by itself $l$ times by a group $G\simeq \left ({\mathbb{Z}}/n{\mathbb{Z}}\right )^{l-1}$ of automorphisms, was constructed by Schreieder to obtain varieties with prescribed Hodge numbers. If $n=3^c$ Schreieder constructed an explicit smooth birational model of it, and Flapan proved that the Kodaira dimension of this smooth model is 1, if $c&gt;1$; if $l=2$ it is a modular elliptic surface; if $l=3$ it admits a fibration in K3 surfaces. In this paper we generalize these results: without any assumption on $n$ and $l$ we prove that $Y_{(n)}^{(l)}$ admits many elliptic fibrations and its Kodaira dimension is at most 1. Moreover, if $l=2$, its minimal resolution is a modular elliptic surface, obtained by a base change of order $n$ on a specific extremal rational elliptic surface; if $l\geq 3$ it has a birational model that admits a fibration in K3 surfaces and a fibration in $(l-1)$-dimensional varieties of Kodaira dimension at most 0.
Nutritional value of a new source of fermented soybean meal fed to growing pigs
Authors: Espinosa Charmaine D , Oliveira Maryane S F , Lagos L Vanessa , Weeden Terry L , Mercado Aileen J , Stein Hans H 
Published: November 2020

AbstractThree experiments were conducted to test the hypothesis that the standardized ileal digestibility (SID) of amino acids (AA), concentrations of digestible energy (DE) and metabolizable energy (ME), and the standardized total tract digestibility (STTD) of P in a new source of fermented soybean meal (Fermex 200) are greater than in conventional soybean meal (SBM-CV). In experiment 1, 9 barrows (initial body weight: 9.17 ± 1.03 kg) were surgically fitted with a T-cannula in the distal ileum and allotted to a triplicated 3 × 3 Latin square design. A nitrogen-free diet and 2 diets that contained cornstarch and SBM-CV or Fermex 200 as the sole source of crude protein (CP), and AA were formulated. Results indicated that there were no difference between SBM-CV and Fermex 200 for SID of CP and AA. In experiment 2, 24 growing pigs (initial body weight: 14.19 ± 1.18 kg) were housed individually in metabolism crates. Pigs were allotted to a corn-based diet or 2 diets that contained corn and SBM-CV or corn and Fermex 200. Feces and urine samples were collected using the marker-to-marker approach with 5-d adaptation and 4-d collection periods. Results indicated that the concentration of DE and ME in Fermex 200 were not different from DE and ME in SBM-CV. In experiment 3, 40 barrows (initial body weight: 11.01 ± 1.38 kg) were allotted to 1 of 4 diets with 10 replicate pigs per diet. Four diets were formulated to contain Fermex 200 or SBM-CV and either 0 or 1,000 units/kg of microbial phytase. Pigs were housed individually in metabolism crates. Fecal samples were collected as explained for experiment 2. Results indicated that the STTD of P in Fermex 200 was greater (P &lt; 0.01) than in SBM-CV, but the addition of microbial phytase to the diets increased the ATTD and STTD of P in SBM-CV, but not in Fermex 200 (interaction; P &lt; 0.01). In conclusion, the SID of AA and concentrations of DE and ME in Fermex 200 were not different from values determined for SBM-CV, but the STTD of P was greater in Fermex 200 than in SBM-CV if microbial phytase was not added to the diet.
Maternal periconceptual nutrition, early pregnancy, and developmental outcomes in beef cattle
Authors: Caton Joel S , Crouse Matthew S , McLean Kyle J , Dahlen Carl R , Ward Alison K , Cushman Robert A , Grazul-Bilska Anna T , Neville Bryan W , Borowicz Pawel P , Reynolds Lawrence P 
Published: November 2020

AbstractThe focus of this review is maternal nutrition during the periconceptual period and offspring developmental outcomes in beef cattle, with an emphasis on the first 50 d of gestation, which represents the embryonic period. Animal agriculture in general, and specifically the beef cattle industry, currently faces immense challenges. The world needs to significantly increase its output of animal food products by 2050 and beyond to meet the food security and agricultural sustainability needs of the rapidly growing human population. Consequently, efficient and sustainable approaches to livestock production are essential. Maternal nutritional status is a major factor that leads to developmental programming of offspring outcomes. Developmental programming refers to the influence of pre-and postnatal factors, such as inappropriate maternal nutrition, that affect growth and development and result in long-term consequences for health and productivity of the offspring. In this review, we discuss recent studies in which we and others have addressed the questions, “Is development programmed periconceptually?” and, if so, “Does it matter practically to the offspring in production settings?” The reviewed studies have demonstrated that the periconceptual period is important not only for pregnancy establishment but also may be a critical period during which fetal, placental, and potentially postnatal development and function are programmed. The evidence for fetal and placental programming during the periconceptual period is strong and implies that research efforts to mitigate the negative and foster the positive benefits of developmental programming need to include robust investigative efforts during the periconceptual period to better understand the implications for life-long health and productivity.
Long-Term Detection in Hair of Zolpidem, Oxazepam and Flunitrazepam in a Case of Drug-Facilitated Sexual Assault
Authors: Carfora Anna , Campobasso Carlo Pietro , Cassandro Paola , Petrella Raffaella , Borriello Renata 
Published: November 2020

Abstract
Drug-facilitated sexual assault (DFSA) cases are pretty common in forensic toxicology. In this case report, a 56-year-old female tourist claimed to have been sexually assaulted by five men after having had a drug-spiked alcoholic drink. Urine samples were collected at 38, 44 and 45 h after the alleged rape. After 7 months, hair strands (28 cm in length) were also sampled to perform the segmental hair testing. The urine samples and decontaminated hair segments were tested for different groups of basic, acidic and neutral substances (γ-hydroxybutyrate or GHB, Z-drugs, barbiturates, benzodiazepines, hypnotics, antipsychotics and drugs of abuse). Gas chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry methods were applied for the qualitative and quantitative analyses. Toxicological analyses performed on the urine samples showed inconclusive findings. Zolpidem, flunitrazepam and oxazepam were detected in the hair segments corresponding to the time frame of the alleged assault. The endogenous levels of GHB were detected along the hair shaft. No drugs were detected in the proximal and distal hair segments or in washing solutions. This DFSA case demonstrated that the segmental toxicological analysis of hair, even when performed 7 months after the sexual assault, can provide evidence consistent with a single exposure to psychoactive drugs, at the time of the offense.
Investment Law before Arbitration
Authors: Hepburn Jarrod , Paparinskis Martins , Skovgaard Poulsen Lauge N , Waibel Michael 
Published: November 2020

ABSTRACT
Investment law was not always about investor–state arbitration. Based on British and German archival materials from the Cold War, this paper shows how aims and priorities in the investment treaty regime changed over time. We find important differences in the role and relative importance of different legal rules then and now. Most notably, national treatment and free transfer clauses were key in early investment law, whereas fair and equitable treatment was regarded as relatively unimportant. At the same time, early drafters did anticipate some of the most contentious issues in modern investment law, including treaty shopping, shareholder protection, and the ‘no greater rights’ proviso.
Metanarratives as a Trap: Critique of Investor–State Arbitration Reform
Authors: Polonskaya Ksenia 
Published: November 2020

ABSTRACT
The ongoing reform of investment arbitration at the United Nations Commission on International Trade Law can have a lasting impact on international investment protection for the decades ahead. This paper examines the current discussions at the United Nations Commission on International Trade Law to explain why the current focus on reforming the procedural aspects of the system is too narrow. As a result of such a narrow approach, the reform risks to miss an opportunity to address the global challenges, e.g. climate change. In advancing its critique of the ongoing reform, the paper adopts the lens of metanarrative by Jean-François Lyotard. By relying on Lyotard, this paper cautions that such values as feasibility and efficiency in conducting the reform should not obscure the need for a critical conversation on the purpose of the reform, which is to ensure the legitimacy of investment arbitration in the future. As this paper argues, a current procedural approach to the reform cannot meaningfully contribute to this objective.
Potential Mosquito Vectors of Dirofilaria immitis and Dirofilaira repens (Spirurida: Onchocercidae) in Aras Valley, Turkey
Authors: Demirci Berna , Bedir Hilal , Taskin Tasci Gencay , Vatansever Zati 
Published: November 2020

Abstract
Dirofilaria immitis (Leidy, 1856) and Dirofilaria repens (Railliet & Henry, 1911) are mosquito-borne filarial nematodes that primarily affect dogs, causing heartworm disease and subcutaneous dirofilariosis. The canine heartworm is reported in different provinces in Turkey. However, studies about the transmitting mosquito species are limited. Hence, this study aimed to investigate potential vectors of D. immitis and D. repens in Aras Valley, Turkey. In total, 17,995 female mosquitoes were collected from eight villages during three mosquito seasons (2012–2014) in Aras Valley, located in north-eastern Turkey. A total of 1,054 DNA pools (527 abdomen and 527 head-thorax) were tested with Dirofilaria primers by multiplex-polymerase chain reaction (PCR). Aedes caspius was the most abundant species in collection sites with 90%; this was followed by Culex theileri Theobald, 1903 (Diptera: Culicidae) (7.31%), Anopheles maculipennis Meigen 1818 (Diptera: Culicidae) (1.28%), Culex pipiens Linnaeus, 1758 (Diptera: Culicidae) (0.43%), (Anopheles) hyrcanus (Pallas, 1771) (Diptera: Culicidae) (0.37%), Aedes vexans (Meigen, 1830) (Diptera: Culicidae) (0.25%), and Culiseta annulata Schrank, 1776 (Diptera:Culicidae) (0.02%). Dirofilaria immitis and D. repens were detected in mosquito pools from five villages. The total Dirofilaria spp. estimated infection rate was 1.33%. The highest estimated infection rate was found in Ae. vexans (6.66%) and the lowest was in Ae. caspius (1.26%). The results show that An. maculipennis sl, Ae. caspius, Ae. vexans, Cx. theileri and Cx. pipiens are potential vectors of D. immitis and D. repens with DNA in head-thorax pools; An. hyrcanus is also a likely vector, but Dirofilaria DNA was found only in abdomen pools for the study area. This study revealed new potential vector species for D. immitis. Mosquitoes with natural infections of D. repens were reported for the first time in Turkey.
Music Therapy Knowledge and Interest: A Survey of Music Education Majors
Authors: Gooding Lori F , Springer D Gregory 
Published: November 2020

Abstract
Music teachers play an important role in exposing students to career options in the field of music. As a result, there is a need to explore music education students’ interest in and knowledge of music therapy. The purpose of this study was to investigate music education students’ exposure to, knowledge of, and willingness to promote music therapy as a career option for prospective collegiate students. A survey was given to 254 music education majors from four research institutions, two with and two without music therapy degree programs. Participants answered demographic, yes/no, Likert-type scale, and open-ended questions about their exposure to, knowledge of, and willingness to promote careers in music therapy. Results indicate that exposure to music therapy occurred in both pre-collegiate and college settings, and that music teachers appear to be influential in exposing students to music therapy. Students often sought out information on music therapy independently, which played an important role in how individuals learned about music therapy, though it has the potential of providing misinformation. Significant differences were found in participants’ knowledge and willingness to promote music therapy as a career option based on the presence of music therapy degree programs. Exposure seemed to be a key factor in music therapy knowledge and promotion; thus, music therapists need to ensure accurate dissemination of music therapy-related information in both pre-collegiate and college settings. Increasing the visibility of the field has the potential to expand interest and potentially attract young musicians well suited for a career in music therapy.
What Drives Diffusion? Anti-Terrorism Legislation in the Arab Middle East and North Africa
Authors: Josua Maria 
Published: November 2020

AbstractSince 9/11 most Arab states in the Middle East and North Africa have introduced anti-terror laws. Are they part of the global-diffusion processes that have spread anti-terrorism legislation worldwide? This paper studies the drivers of anti-terrorism legislation in these Arab states, contributing to the emerging research on authoritarian diffusion. The analysis demonstrates that regional and domestic explanations, rather than diffusion from the international level, are key. This is evident from the chronological order in which anti-terror legislation has appeared, the regionally inspired definitions of terrorism, and the immediate drivers behind such laws.The past few decades have seen two temporal clusters of new anti-terrorism legislation in the Arab world. In the first decade of the new millennium, mainly domestic terror attacks drove the adoption of anti-terror laws. Meanwhile, regional efforts to comply with international counterterrorism efforts after the 9/11 attacks played a subordinate role. In a second wave following the Arab uprisings of 2011, anti-terror legislation was driven increasingly by authoritarian governments’ desire to penalize dissent, as they sought to inhibit the spread of protests on the regional level.A systematic overview of the terrorism definitions contained in the new laws offers evidence for policy convergence. Instead of adhering to internationally recognized understandings of terrorism, the definitions in Arab legislation follow regional examples. The vague definitions of terrorism featured in the new laws allow for repressive measures being taken against challengers of authoritarian rule.
Precise mass measurements for the double neutron star system J1829+2456
Authors: Haniewicz H T , Ferdman R D , Freire P C C , Champion D J , Bunting K A , Lorimer D R , McLaughlin M A 
Published: November 2020

ABSTRACT
PSR J1829+2456 is a radio pulsar in a relativistic binary system with another neutron star. It has a rotational period of 41 ms and a mildly eccentric (e = 0.14) 28 h orbit. We have continued its observations with the Arecibo radio telescope and have now measured the individual neutron star masses of this system: The pulsar and companion masses are $1.306\, \pm \, 0.007\, \mathrm{M}_{\odot}$ and $1.299\, \pm \, 0.007\, \mathrm{M}_{\odot}$ ($2\sigma - 95{{\ \rm per\ cent}}$ confidence, unless stated otherwise), respectively. We have also measured the proper motion for this system and used it to estimate a space velocity of $49^{+77}_{-30}$$\, \mathrm{km}\, \mathrm{s}^{-1}$ with respect to the local standard of rest. The relatively low values for companion mass, space velocity, and orbital eccentricity in this system make it similar to other double neutron star systems in which the second-formed neutron star is thought to have formed in a low-kick, low mass-loss, symmetric supernova.