bluuebunny/crossref_metadata_2025_split huggingface dataset:
An efficient controlled elitism non-dominated sorting genetic algorithm for multi-objective supplier selection under fuzziness
Authors: Hajipour Vahid , Tavana Madjid , Santos-Arteaga Francisco J , Alinezhad Alireza , Di Caprio Debora 
Published: February 2020

Abstract
Supplier selection and order allocation constitute vital strategic decisions that must be made by managers within supply chain management environments. In this paper, we propose a multi-objective fuzzy model for supplier selection and order allocation in a two-level supply chain with multi-period, multi-source, and multi-product characteristics. The supplier evaluation objectives considered in this model include cost, delay, and electronic-waste (e-waste) minimization, as well as coverage and weight maximization. A signal function is used to model the price discount offered by the suppliers. Triangular fuzzy numbers are used to deal with the uncertainty of delay and e-waste parameters while the fuzzy Technique for Order Performance by Similarity to Ideal Solution (TOPSIS) is used to obtain the weights of the suppliers. The resulting NP-hard problem, a Pareto-based meta-heuristic algorithm called controlled elitism non-dominated sorting genetic algorithm (CENSGA), is developed. The Non-dominated Sorting Genetic Algorithm (NSGA-II) and Multi-Objective Particle Swarm Optimization (MOPSO) are used to validate the applicability of the CENSGA algorithm and the Taguchi technique to tune the parameters of the algorithms. The results are analysed using graphical and statistical comparisons illustrating how the proposed CENSGA dominates NSGA-II and MOPSO in terms of mean ideal solution distance (MID) and spacing metrics.
Formation of planetary populations − II. Effects of initial disc size and radial dust drift
Authors: Alessi Matthew , Pudritz Ralph E , Cridland Alex J 
Published: February 2020

ABSTRACT
Recent ALMA observations indicate that while a range of disc sizes exist, typical disc radii are small, and that radial dust drift affects the distribution of solids in discs. Here, we explore the consequences of these features in planet population synthesis models. A key feature of our model is planet traps – barriers to otherwise rapid type-I migration of forming planets – for which we include the ice line, heat transition, and outer edge of the dead zone. We find that the ice line plays a fundamental role in the formation of warm Jupiters. In particular, the ratio of super Earths to warm Jupiters formed at the ice line depends sensitively on the initial disc radius. Initial gas disc radii of ∼50 au results in the largest super Earth populations, while both larger and smaller disc sizes result in the ice line producing more gas giants near 1 au. This transition between typical planet class formed at the ice line at various disc radii confirms that planet formation is fundamentally linked to disc properties (in this case, disc size), and is a result that is only seen when dust evolution effects are included in our models. Additionally, we find that including radial dust drift results in the formation of more super Earths between 0.1 and 1 au, having shorter orbital radii than those produced in models where dust evolution effects are not included.
Ollier disease: the first report in Syria
Authors: Dhemesh Yaseen , Tawekji Talha , Abdul-Baki Mohammad-Nasan , Abi-Zamr Ghazal , Ali Sawssan 
Published: February 2020

Abstract
Ollier disease is a rare nonhereditary skeletal disorder, characterized by multiple enchondromas, which are noncancerous growth of cartilage. In this report, we present a case of Ollier disease in a 10-year-old Syrian boy. The patient presented with multiple boney masses on hands; he had a history of pathological fractures when he was 5, which caused crippling. We analyzed the clinical, radiographical and pathological characteristics of our patient, which helped us to reach the final diagnosis. Ollier disease is a benign bone tumor, but it has a risk of malignant transformation into chondrosarcoma. The aim of this report is to document the presence of Ollier disease in Syria to help other Syrian physicians considering this disease in the differential diagnosis if they face similar presentations.
Effect of Manual Upper Eyelid Elevation on Intraocular Pressure Measurement by Four Different Tonometers
Authors: Nakakura Shunsuke , Mori Etsuko , Fujio Yuki , Fujisawa Yasuko , Matsuya Kanae , Kobayashi Yui , Oogi Satomi , Shiraishi Miku , Tabuchi Hitoshi , Asaoka Ryo , Kiuchi Yoshiaki 
Published: February 2020

SIGNIFICANCE
This study is the first to show that the manual upper eyelid elevation (manual UEE) that is commonly used to prevent disruption of the IOP measurement due to blinking or upper eyelid contact with the tip of the tonometer does not affect the IOP values.

PURPOSE
We investigated whether manual UEE affects the IOP readings using three rebound tonometers (Icare TA01i, Icare PRO, and Icare ic100) and Goldmann applanation tonometry (GAT).

METHODS
One eye was measured for 101 patients (56 eyes of primary open-angle glaucoma patients and 45 healthy subjects). The IOPs were measured without and with manual UEE. Each IOP was measured twice; the measurement order using the tonometers was randomly selected. In addition, palpebral fissure height (distance between the upper and lower eyelids) was measured.

RESULTS
The IOPs without manual UEE were 12.1 ± 2.9, 13.3 ± 2.7, 11.7 ± 2.9, and 16.0 ± 3.2 mmHg (Icare TA01i, Icare PRO, Icare ic100, and GAT), and those with manual UEE were 12.3 ± 3.0, 13.3 ± 2.8, 11.7 ± 2.9, and 16.0 ± 3.3, respectively. No significant difference was found between the IOP without and with manual UEE (IOP difference; all, P > .50; paired t test). Multiple linear regression analyses revealed that palpebral fissure height did not affect IOP difference for any of the tonometers.

CONCLUSIONS
Simple manual UEE when measuring the IOP has little effect on the IOP obtained using all current rebound tonometers and GAT.
Assessing Corneal Speckle in Optical Coherence Tomography: A New Look at Glaucomatous Eyes
Authors: Iskander D. Robert , Kostyszak Małgorzata A. , Jesus Danilo A. , Majewska Małgorzata , Danielewska Monika E. , Krzyżanowska-Berkowska Patrycja 
Published: February 2020

SIGNIFICANCEOptical coherence tomography speckle is used here in an unconventional way as the indirect source of information on tissue microstructure. The study reveals that the corneal speckle of glaucoma suspects has a similar relationship between the parameters of scattering exhibited in glaucoma patients.PURPOSEThe purpose of this study was to evaluate the potential of optical coherence tomography imaging of the cornea in early diagnosis of glaucoma.METHODSCorneas of 64 subjects of three groups, including 18 primary open-angle glaucoma patients, 24 glaucoma suspects with normal levels of IOP and uncompromised visual field, and 22 age-matched controls, were imaged with spectral optical coherence tomography. A central region of interest in each optical coherence tomography image visualizing the stroma was automatically extracted, and the intensity data within that region were fit with the generalized gamma distribution. Its parameters describe the scatterer cross section and scatterer density and indirectly assess corneal microstructure. In addition, subjects underwent measurements of IOP, visual field, Heidelberg Retinal Tomography, retinal nerve fiber layer thickness, and biometry. Group means of all parameters were tested for equality. Within each group of subjects, correlation was evaluated between the statistical parameters of the corneal speckle.RESULTSGlaucoma suspects had statistically significantly different IOP, visual field parameters, mean retinal fiber layer thickness, and central corneal thickness from those of glaucoma patients but not from those of the control group. The parameters of the corneal speckle were not significantly different between the groups, but they showed a markedly higher and statistically significant coefficient of determination for glaucoma patients and suspects than that for the control group (0.927 and 0.707 vs. 0.336).CONCLUSIONSThe results indicate that glaucoma suspects have similar relationship between the corneal scatterer cross section and scatterer density to that exhibited in the glaucoma patients but markedly different from that of healthy controls.
Predicting human health from biofluid-based metabolomics using machine learning
Authors: Evans Ethan D. , Duvallet Claire , Chu Nathaniel D. , Oberst Michael K. , Murphy Michael A. , Rockafellow Isaac , Sontag David , Alm Eric J. 
Published: February 2020

AbstractBiofluid-based metabolomics enables the profiling of thousands of molecules and has the potential to provide highly accurate, minimally invasive diagnostics for a range of health conditions. However, typical metabolomics studies focus on only a few statistically significant features. We study the applicability of machine learning for health state-prediction across 35 human mass spectrometry-based metabolomics studies. Models trained on all features outperform those using only significant features and frequently provide high predictive performance across nine health states, despite disparate experimental conditions and disease contexts. Combining data from different experimental settings (e.g. sample type, instrument, chromatography) within a study minimally alters predictive performance, suggesting information overlap between different methods. Using only non-significant features, we still often obtain high predictive performance. To facilitate further advances, we provide all data online. This work highlights the applicability of biofluid-based metabolomics with data-driven analysis for health state diagnostics.
DNA methylation aging clocks and pancreatic cancer risk: Pooled analysis of three prospective nested case-control studies
Authors: Chung Mei , Ruan Mengyuan , Zhao Naisi , Koestler Devin C. , De Vivo Immaculata , Kelsey Karl T. , Michaud Dominique S. 
Published: February 2020

Structured AbstractBackgroundPancreatic cancer is projected to become the second leading cause of cancer-related death by 2030 in the United States. DNA methylation (DNAm) age may reflect age-related variations in the biological changes and abnormalities related to cancer development.MethodWe conducted a pooled analysis using prediagnostic blood samples of pancreatic cancer cases and matched controls selected from the Nurses’ Health Study (NHS), the Physician’s Health Study (PHS), and the Health Professionals Follow-up Study (HPFS). We used three DNAm aging clocks (Hannum, Horvath, and PhenoAge) to estimate subjects’ DNAm age, epigenetic age acceleration (AA) and intrinsic epigenetic age acceleration (IEAA) metrics. We performed conditional logistic regression and multivariable Cox proportional hazard regression to examine associations between six AA and IEAA metrics and risk of pancreatic cancer and survival, respectively.ResultsA total of 393 incidence pancreatic cancer cases and 431 matched controls from the NHS, PHS, and HPFS cohorts were included in this analysis. The medians of all three epigenetic AA and three IEAA metrics were consistently above zero (indicating accelerated age) among cases, while they were below zero (indicating decelerated age) among the matched controls. Comparing participants in the highest quartile of age acceleration metrics, the pancreatic cancer risks were significantly increased by 67% to 83% for Hannum and PhenoAge AA or IEAA metrics with minimal of 7- to 9-years accelerated ages. Except for Hovarth AA and IEAA metrics, there were significant dose-response trends, such that higher age accelerations were associated with higher pancreatic cancer risk, but the relationships were nonlinear. Stratified analyses showed heterogeneous associations, varying by participants’ characteristics and by epigenetic AA or IEAA metrics. As time to diagnosis increased, the ORs of pancreatic cancer for the Hannum AA and Horvath AA or IEAA metrics trended upwards, while the ORs for the PhenoAge AA or IEAA and Hannum IEAA metrics trended downward. Overall, we observed no significant association between pancreatic cancer survival and any of the prediagnostic epigenetic AA or IEAA metrics.ConclusionOur results indicate DNAm age acceleration is associated with an increased risk of pancreatic cancer in a nonlinear, dose-response manner. Epigenetic IEAA metrics may be a useful addition to current methods for pancreatic cancer risk prediction.
Direct Measurement of Rates of Asymptomatic Infection and Clinical Care-Seeking for Seasonal Coronavirus
Authors: Shaman Jeffrey , Galanti Marta 
Published: February 2020

AbstractThe pandemic potential of the novel coronavirus (nCoV) that emerged in Wuhan, China, during December 2019 is strongly tied to the number and contagiousness of undocumented human infections. Here we present findings from a proactive longitudinal sampling study of acute viral respiratory infections that documents rates of asymptomatic infection and clinical care seeking for seasonal coronavirus. We find that the majority of infections are asymptomatic by most symptom definitions and that only 4% of individuals experiencing a seasonal coronavirus infection episode sought medical care for their symptoms. These numbers indicate that a very high percentage of seasonal coronavirus infections are undocumented and provide a reference for understanding the spread of the emergent nCoV.
A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer’s disease
Authors: Gharahkhani Puya , Jorgenson Eric , Hysi Pirro , Khawaja Anthony P. , Pendergrass Sarah , Han Xikun , Ong Jue Sheng , Hewitt Alex W. , Segre Ayellet , Igo Robert P. , Choquet Helene , Qassim Ayub , Josyula Navya S , Cooke Bailey Jessica N. , Bonnemaijer Pieter , Iglesias Adriana , Siggs Owen M. , Young Terri , Vitart Veronique , Thiadens Alberta A.H.J. , Karjalainen Juha , Uebe Steffen , Melles Ronald B. , Nair K. Saidas , Luben Robert , Simcoe Mark , Amersinghe Nishani , Cree Angela J. , Hohn Rene , Poplawski Alicia , Chen (CUHK) Li Jia , Cheng Ching-Yu , Vithana Eranga Nishanthie ,   NEIGHBORHOOD consortium,   ANZRAG consortium,   Biobank Japan project,   FinnGen study,   UK Biobank Eye and Vision Consortium,   GIGA study group,   23andMe Research Team, Tamiya Gen , Shiga Yukihiro , Yamamoto Masayuki , Nakazawa Toru , Rouhana John , Currant Hannah , Birney Ewan , Wang Xin , Auton Adam , Ashaye Adeyinka , Olawoye Olusola , Williams Susan E. , Akafo Stephen , Ramsay Michele , Hashimoto Kazuki , Kamatani Yoichito , Akiama Masato , Momozawa Yukihide , Foster Paul J. , Khaw Peng T. , Morgan James E. , Strouthidis Nicholas G. , Kraft Peter , Kang Jae Hee , Pui Pang (CUHK) Calvin Chi , Pasutto Francesca , Mitchell Paul , Lotery Andrew J. , Palotie Aarno , van Duijn Cornelia , Haines Jonathan , Hammond Chris , Pasquale Louis R. , Klaver Caroline C.W. , Hauser Michael , Khor Chiea Chuen , Mackey David A. , Kubo Michiaki , Aung Tin , Craig Jamie , MacGregor Stuart , Wiggs Janey 
Published: February 2020

AbstractWe conducted a large multi-ethnic meta-analysis of genome-wide association studies for primary open-angle glaucoma (POAG) on a total of 34,179 cases vs 349,321 controls, and identified 127 independent risk loci, almost doubling the number of known loci for POAG. The majority of loci have broadly consistent effect across European, Asian and African ancestries. We identify a link, both genome-wide and at specific loci, between POAG and Alzheimer’s disease. Gene expression data and bioinformatic functional analyses provide further support for the functional relevance of the POAG risk genes. Several drug compounds target these risk genes and may be potential candidates for developing novel POAG treatments.
The use of simultaneous SEEG and MEG in localising seizure onset zone
Authors: Vivekananda Umesh , Cao Chunyan , Liu Wei , Zhang Jing , Rugg-Gunn Fergus , Walker Matthew C , Litvak Vladimir , Sun Bomin , Zhan Shikun 
Published: February 2020

AbstractObjectivesBoth Magnetoencephalography (MEG) and stereo-electroencephalography (SEEG) are used in presurgical epilepsy assessment, with contrasting advantages and limitations. It is not known whether combined recording using both modalities can maintain inherent advantages whilst overcoming these limitations e.g. recording from deep brain sources whilst preserving good spatial resolution.Methods24 adult and paediatric patients who underwent SEEG study for pre-surgical evaluation of focal drug-resistant epilepsy, were recorded using simultaneous SEEG-MEG, of which 14 had abnormal interictal activity during recording. The 14 patients were divided into two groups; those with presumed superficial (n=7) and deep (n=7) brain interictal activity.ResultsThere was no significant difference between SEEG and MEG in identifying superficial spikes (p=0.135) and SEEG was significantly better at detecting deep spikes (p=0.002). Mean distance across patients between SEEG channel with highest average spike amplitude and MEG dipole was 26.6+/-3.6 mm for superficial sources, and 21.5 +/- 2.04 mm for deep sources, even though for some of the latter (n=4) no MEG spikes were detected and MEG dipole was fitted to a SEEG interictal activity triggered average. Removal of MEG dipole was associated with 1 year seizure freedom in 5/6 patients with superficial source, and 4/6 patients with deep source.ConclusionsAlthough SEEG has greater sensitivity in identifying interictal activity from deeper sources, an MEG source can be localised using SEEG information, thereby providing useful whole brain context to SEEG and potential role in epilepsy surgery planning.
High Risk Infants who are Low Dose Tolerant after Peanut Oral Food Challenges
Authors: Lin Adora , Uygungil Burcin , Robbins Karen , Ackerman Olivia , Sharma Hemant 
Published: February 2020

AbstractBackgroundEarly peanut (PN) introduction may prevent peanut allergy in at-risk children. Little data exists regarding early introduction for infants with large skin prick tests (SPT) or high peanut IgE levels, who are not often offered oral food challenges (OFC).ObjectiveTo retrospectively assess tolerance of a low dose (1 gram) of peanut in infants at risk for peanut allergy, including highest-risk infants (HRI) with SPT wheal >7mm.MethodsWe reviewed PN OFCs performed over a two-year period at our pediatric allergy center. Low-dose PN OFC was offered to all infants considered at risk for PN allergy, regardless of peanut SPT or IgE results. Dosing was escalated after OFC at home.ResultsOf infants with SPT wheal <=4 mm (n=30), 29 (97%) were low-dose-tolerant. Of those with SPT >4 mm (n=40), 25 (63%) were low-dose-tolerant, and Ara h2 IgE was significantly lower compared to non-tolerant individuals (median 0.62 versus 6.49 kU/L, p<0.05). Among HRI with SPT >7mm (n=22), 12 (55%) were tolerant, with median SPT 9mm (range 8-11mm), PN-IgE 1.1 kU/L (0.3-10.7 kU/L) and Ara h2 1.6 kU/L (0-9.57 kU/L). Age, sex, race, eczema, and egg sensitization did not affect tolerance regardless of SPT size. After 3-6 months, most infants tolerant at OFC were gradually able to consume larger doses of PN.ConclusionMany infants with PN-SPT >4mm are tolerant of low-dose peanut, and Ara h 2 IgE may be predictive for clinical tolerance among these infants. Low-dose PN-OFC with gradual updosing may help prevent PN allergy in a greater number of at-risk infants.
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing
Authors: Khoo K.K. , Galleano I. , Gasparri F. , Wieneke R. , Harms H. , Poulsen M.H. , Chua H.C. , Wulf M. , Tampé R. , Pless S.A. 
Published: February 2020

AbstractManipulation of proteins by chemical modification is a powerful way to decipher their function or harness that function for therapeutic purposes. Despite recent progress in ribosome-dependent and semi-synthetic chemical modifications, these techniques sometimes have limitations in the number and type of modifications that can be simultaneously introduced or their application in live eukaryotic cells. Here we present a new approach to incorporate single or multiple post-translational modifications or non-canonical amino acids into soluble and membrane proteins expressed in eukaryotic cells. We insert synthetic peptides into proteins of interest via tandem protein trans-splicing using two orthogonal split intein pairs and validate our approach by investigating different aspects of GFP, NaV1.5 and P2X2 receptor function. Because the approach can introduce virtually any chemical modification into both intracellular and extracellular regions of target proteins, we anticipate that it will overcome some of the drawbacks of other semi-synthetic or ribosome-dependent methods to engineer proteins.
The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy
Authors: Zhou Deyuan , Wang Wei , Zhou Rouxi , He Miao , Gong Xia , Li Yuting , Huang Wenyong 
Published: February 2020

AbstractPurposeTo determine whether there was a change in the fundus of the eye in diabetic patients without retinopathy after insulin therapy.MethodsThe diabetic patients without retinopathy were included in this study. A swept-source optical coherence tomography/angiography (SS-OCT/A) was used to obtain the measurements of macular retinal nerve fibre layer (mRNFL) thickness, ganglion cell-inner plexiform layer (GC-IPL) thickness, retinal thickness (RT), macular choroidal thickness (MCT), peripapillary retinal nerve fibre layer (pRNFL) thickness, peripapillary choroidal thickness (PCT), and perfused vascular density (PVD). Univariable and multivariable regression analyses were performed to explore the influence of insulin use on measurements of OCT/A.ResultsA total of 1140 patients used insulin (using group), and 126 patients did not use insulin (without group). The average MCT of the using group was 171.3±67.8 μm, which was thinner than that in the without group (190.2±74.7 μm) (P=0.012). The average PVD of the using group (48.0±2.1 μm) was less than that in the without group (48.7±2.1 μm) (P<0.001). After adjusting for age, gender, axial length, duration, HbA1c, systolic blood pressure, diastolic blood pressure, cholesterol, serum creatinine, insulin use was significantly associated with thinner MCT (beta=-16.12μm; 95%CI:-29.42, −2.81μm; P= 0.018) and lower PVD (beta=-0.79; 95%CI: −1.22, −0.36; P<0.001).ConclusionThe use of insulin by diabetic patients without retinopathy might decrease the MCT and PVD compared to patients who did not use insulin, which helps to better understanding the role of insulin use on higher risk for diabetic retinopathy.
Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi
Authors: Itoh Yuzuru , Naschberger Andreas , Mortezaei Narges , Herrmann Johannes M. , Amunts Alexey 
Published: February 2020

AbstractMitoribosomes are specialized protein synthesis machineries in mitochondria. However, how mRNA binds to its dedicated channel, and tRNA moves as the mitoribosomal subunit rotate with respect to each other is not understood. We report models of the translating fungal mitoribosome with mRNA, tRNA and nascent polypeptide, as well as an assembly intermediate. Nicotinamide adenine dinucleotide (NAD) is found in the central protuberance of the large subunit, and the ATPase inhibitory factor 1 (IF1) in the small subunit. The models of the active mitoribosome explain how mRNA binds through a dedicated protein platform on the small subunit, tRNA is translocated with the help of the protein mL108, bridging it with L1 stalk on the large subunit, and nascent polypeptide paths through a newly shaped exit tunnel involving a series of structural rearrangements. An assembly intermediate is modeled with the maturation factor Atp25, providing insight in to the biogenesis of the mitoribosomal large subunit and translation regulation.