bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare Case Report: Malignant Vulvar Melanoma
Authors: ul Ain Qurrat , Rao Bharati 
Published: January 2020

AbstractCancer of the vulva is not a common disease. It accounts for approximately 4% of cancers in the female reproductive organs and 0.6% of all cancers in women. Malignant melanomas of the vulva are rare tumors located in areas of the body not exposed to ultraviolet radiation. Although vulvar melanomas account for less than 1% of all melanomas, they are the second most common type of vulvar malignancy accounting for around 10% of all malignant tumors involving the vulva. Presentation is typically a decade later than cutaneous melanoma with a tendency to late metastases and poorer prognosis. Given their rarity, the treatment paradigm is less clearly defined and largely extrapolated from that of cutaneous melanomas. A case of Mrs. Y, 70 years old, P3L1 presented with complaints of swelling in the labial region for two and a half months, associated with severe itching, was reported. She also had C/O white discharge PV for 2 months, which was non-foul smelling and not blood-stained; on examination, her abdomen was soft and non-tender. A local examination found 2 × 3 cm growth arising from labia minora, irregular surface, and hyperpigmented lesion with white patches and ulcerated surface. Left inguinal lymph nodes were palpable. Per speculum examination revealed pigmented lesions over the anterior vaginal wall, anterior and posterior lip of cervix, cervix and vagina healthy. Excisional biopsy, fractional curettage, and FNAC were done. Histopathology of the specimen showed the diagnosis of nodular melanoma (tumorigenic melanoma), Clark’s level IV. Cervical biopsy showed the features of chronic cervicitis. FNAC showed the features of metastatic malignant melanoma.
Adaptive deep residual network for single image super-resolution
Authors: Liu Shuai , Gang Ruipeng , Li Chenghua , Song Ruixia 
Published: January 2020

AbstractIn recent years, deep learning has achieved great success in the field of image processing. In the single image super-resolution (SISR) task, the convolutional neural network (CNN) extracts the features of the image through deeper layers, and has achieved impressive results. In this paper, we propose a single image super-resolution model based on Adaptive Deep Residual named as ADR-SR, which uses the Input Output Same Size (IOSS) structure, and releases the dependence of upsampling layers compared with the existing SR methods. Specifically, the key element of our model is the Adaptive Residual Block (ARB), which replaces the commonly used constant factor with an adaptive residual factor. The experiments prove the effectiveness of our ADR-SR model, which can not only reconstruct images with better visual effects, but also get better objective performances.
Influence of Octahedral Cation Distribution in Montmorillonite on Interlayer Hydrogen Counter-Ion Retention Strength via First-Principles Calculations
Authors: Li Yayu W. , Schulthess Cristian P. , Co Kevin , Sahoo Sanjubala , Alpay S. Pamir 
Published: January 2020

AbstractAlthough multiple types of adsorption sites have long been observed in montmorillonite, a consistent explanation about the chemical structure of these adsorption sites has not yet been established. Identifying the cation interlayer adsorption sites based on the octahedral cation distribution on montmorillonite was investigated in this study by using a Density Functional Theory (DFT) simulation. A clay structural model (H[Al6MgFe]Si16O40(OH)8) with a similar composition to Wyoming SWy-1 montmorillonite was built, where two octahedral Al were respectively substituted by Fe and Mg, and H+ was the charge compensating cation. This model had twenty-one different possible configurations as a function of the distribution of octahedral Al, Fe, and Mg cations. The DFT simulations of 15 of these different configurations showed no preference for the formation of any configuration with a specific octahedral Fe-Mg distance. However, the H+ adsorption energy was separated into three distinct groups based on the number of octahedral jumps from Fe to Mg atoms. The H+ adsorption energy significantly decreased with increasing number of octahedral jumps from Fe to Mg. Assuming an even probability of occurrence of 21 octahedral structures in montmorillonite, the percentages of these three groups are 43, 43, and 14%, respectively, which are very close to the three major sites on montmorillonite from published cation adsorption data. These DFT simulations offer an entirely new explanation for the location and chemical structure of the three major adsorption sites on montmorillonite, namely, all three sites are in the interlayer, and their adsorption strengths are a function of the number of octahedral jumps from Fe to Mg atoms.
atom: A Matlab Package for Manipulation of Molecular Systems
Authors: Holmboe Michael 
Published: January 2020

AbstractThis work presents Atomistic Topology Operations in MATLAB (atom), an open source library of modular MATLAB routines which comprise a general and flexible framework for manipulation of atomistic systems. The purpose of the atom library is simply to facilitate common operations performed for construction, manipulation, or structural analysis. Due to the data structure used, atoms and molecules can be operated upon based on different chemical names or attributes, such as atom- or molecule-ID, name, residue name, charge, positions, etc. Furthermore, the Bond Valence Method and a neighbor-distance analysis can be performed to assign many chemical properties of inorganic molecules. Apart from reading and writing common coordinate files (.pdb, .xyz, .gro, .cif) and trajectories (.dcd, .trr, .xtc; binary formats are parsed via third-party packages), the atom library can also be used to generate topology files with bonding and angle information taking the periodic boundary conditions into account, and supports basic Gromacs, NAMD, LAMMPS, and RASPA2 topology file formats. Focusing on clay-mineral systems, the library supports CLAYFF (Cygan, 2004) but can also generate topology files for the INTERFACE forcefield (Heinz, 2005, 2013) for Gromacs and NAMD.
Hormone therapy decision‐making processes: Transgender youth and parents
Authors: Clark Beth A. , Marshall Sheila K. , Saewyc Elizabeth M. 
Published: January 2020

ABSTRACTIntroductionThis study explored how transgender (trans) youth and parents of trans youth made decisions around hormone therapy initiation as well as trans youth experiences of barriers to care.MethodsParticipants included 21 trans youth (ages 14–18) and 15 parents of trans youth who resided in British Columbia, Canada. Data for this grounded theory research consisted of transcripts and lifeline drawings collected through semi‐structured interviews conducted August 2016 through February 2017.ResultsThe decision‐making processes of youth and of parents are illustrated in three‐phase temporal models, starting with discovery, leading to (inter)action while seeking care, and reflection after hormone therapy initiation. Youth who sought hormone therapy were clear about their decision to access this care. Throughout these processes, youth experienced numerous parent‐ and system‐related barriers to care. Youth with the lowest levels of parent support experienced more system barriers, with non‐binary/genderfluid youth experiencing greater barriers and less support for hormone therapy than youth with binary genders. A new barrier identified in this study was health care provider imposed requirements for parental involvement and/or approval, which rendered some youth unable access to hormone therapy.ConclusionsHealth care providers should be aware of the deliberation and information‐seeking in which youth engage prior to seeking care as well as the temporally misaligned decision‐making processes of youth and parents. Understanding the challenges trans youth experience due to insufficient parental support and system barriers can provide important context for health care providers striving to provide accessible, gender‐affirming care and decision‐making support for trans youth.
Navigating the cyber-insurance landscape to protect MSPs and their clients
Authors: Mittel Michael 
Published: January 2020

The level and severity of data breaches and cyber attacks occurring today continues to focus the minds of organisations across the world. According to Absolute Market Insights: “It is estimated that over the next five years, cybercrime could potentially cost companies $5.2tr every year.” 1 Moreover, according to a study by IBM and the Ponemon Institute, the average cost of a data breach in 2018 reached $3.86m, up 6.4% from the year before. 2 There is a growing awareness among enterprises that having cyber insurance is essential. And so we are seeing an escalating interest in this kind of insurance. Managed service providers (MSPs) are likely to be especially attracted to this proposition as their strategic focus is on dealing with networks and they can take on the role of a trusted consultant for their clients. The knowledge MSPs typically have of their clients’ network infrastructure, and their understanding of the cyber security market, allows them to pinpoint the bigger threats, argues Michael Mittel of RapidFire Tools.
Naloxone dosing in the era of ultra-potent opioid overdoses: a systematic review
Authors: Moe Jessica , Godwin Jesse , Purssell Roy , O'Sullivan Fiona , Hau Jeffrey P. , Purssell Elizabeth , Curran Jason , Doyle-Waters Mary M. , Brasher Penelope M.A. , Buxton Jane A. , Hohl Corinne M. 
Published: January 2020

ABSTRACTObjectivesEvaluate the relationship between naloxone dose (initial and cumulative) and opioid toxicity reversal and adverse events in undifferentiated and presumed fentanyl/ultra-potent opioid overdoses.MethodsWe searched Embase, MEDLINE, Cochrane Central Register of Controlled Trials, DARE, CINAHL, Science Citation Index, reference lists, toxicology websites, and conference proceedings (1972 to 2018). We included interventional, observational, and case studies/series reporting on naloxone dose and opioid toxicity reversal or adverse events in people >12 years old.ResultsA total of 174 studies (110 case reports/series, 57 observational, 7 interventional) with 26,660 subjects (median age 35 years; 74% male). Heterogeneity precluded meta-analysis. Where reported, we abstracted naloxone dose and proportion of patients with toxicity reversal. Among patients with presumed exposure to fentanyl/ultra-potent opioids, 56.9% (617/1,085) responded to an initial naloxone dose ≤0.4 mg compared with 80.2% (170/212) of heroin users, and 30.4% (7/23) responded to an initial naloxone dose >0.4 mg compared with 59.1% (1,434/2,428) of heroin users. Among patients who responded, median cumulative naloxone doses were higher for presumed fentanyl/ultra-potent opioids than heroin overdoses in North America, both before 2015 (fentanyl/ultra-potent opioids: 1.8 mg [interquartile interval {IQI}, 1.0, 4.0]; heroin: 0.8 mg [IQI, 0.4, 0.8]) and after 2015 (fentanyl/ultra-potent opioids: 3.4 mg [IQI, 3.0, 4.1]); heroin: 2 mg [IQI, 1.4, 2.0]). Where adverse events were reported, 11% (490/4,414) of subjects experienced withdrawal. Variable reporting, heterogeneity and poor-quality studies limit conclusions.ConclusionsPractitioners have used higher initial doses, and in some cases higher cumulative naloxone doses to reverse toxicity due to presumed fentanyl/ultra-potent opioid exposure compared with other opioids. High-quality comparative naloxone dosing studies assessing effectiveness and safety are needed.
Examination of commercially available bird feed for weed seed contaminants
Authors: Oseland Eric , Bish Mandy , Spinka Christine , Bradley Kevin 
Published: January 2020

AbstractIn 2016 and 2017, 98 separate commercially available bird feed mixes were examined for the presence of weed seed. All weed seed contaminants were counted and identified by species. Amaranthus species were present in 94 of the 98 bags of bird feed. Amaranthus species present in bird feed mixes included waterhemp [Amaranthus tuberculatus (Moq.) Sauer], redroot pigweed (Amaranthus retroflexus L.), Palmer amaranth (Amaranthus palmeri S. Watson), smooth pigweed (Amaranthus hybridus L.), and tumble pigweed (Amaranthus albus L.). Amaranthus palmeri was present in 27 of the 98 mixes. Seed of common ragweed (Ambrosia artemisiifolia L.), kochia [Bassia scoparia (L.) A.J. Scott], grain sorghum [Sorghum bicolor (L.) Moench], wild buckwheat (Fallopia convolvulus L., syn: Polygonum convolvulus), common lambsquarters (Chenopodium album L.), large crabgrass [Digitaria sanguinalis (L.) Scop.], and Setaria species were also present in bird feed mixes. A greenhouse assay to determine Amaranthus species seed germinability and resistance to glyphosate revealed that approximately 19% of Amaranthus seed in bird feed mixes are readily germinable, and five mixes contained A. tuberculatus and A. palmeri seed that were resistant to glyphosate. Results from linear regression and t-test analysis indicate that when proso millet (Panicum miliaceum L.), grain sorghum, and corn (Zea mays L.) were present in feed mixes, Amaranthus seed contamination was increased. The presence of proso millet and grain sorghum also increased contamination of grass weed species, while sunflower (Helianthus annuus L.) increased A. artemisiifolia contamination and safflower (Carthamus tinctorius L.) increased contamination of Bassia scoparia.
Local Matters: Queer Scenes in 1960s Manchester, Plymouth, and Brighton
Authors: Cook Matt 
Published: January 2020

AbstractThis article compares queer social scenes in the 1960s in three English towns and cities: Brighton and Plymouth on the south coast and Manchester in the northwest. It considers how queer experience in these places was affected by local identities, demographics, geographies, and socioeconomic circumstances and so demonstrates how and why the local matters to queer scenes and lives, even in the midst of wider burgeoning mass and connective cultures. A focus on London has dominated analysis of both the “Swinging Sixties” and queer lives in England; this article shows how different queer experience outside that city could be. Despite multiple resonances and connections, London's queer story cannot stand in for that of other places.
In-Plane and Out-of Plane Failure of an Ice Sheet using Peridynamics
Authors: Vazic Bozo , Oterkus Erkan , Oterkus Selda 
Published: January 2020

ABSTRACTWhen dealing with ice structure interaction modeling, such as designs for offshore structures/icebreakers or predicting ice cover’s bearing capacity for transportation, it is essential to determine the most important failure modes of ice. Structural properties, ice material properties, ice-structure interaction processes, and ice sheet geometries have significant effect on failure modes. In this paper two most frequently observed failure modes are studied; splitting failure mode for in-plane failure of finite ice sheet and out-of-plane failure of semi-infinite ice sheet. Peridynamic theory was used to determine the load necessary for inplane failure of a finite ice sheet. Moreover, the relationship between radial crack initiation load and measured out-of-plane failure load for a semi-infinite ice sheet is established. To achieve this, two peridynamic models are developed. First model is a 2 dimensional bond based peridynamic model of a plate with initial crack used for the in-plane case. Second model is based on a Mindlin plate resting on a Winkler elastic foundation formulation for out-of-plane case. Numerical results obtained using peridynamics are compared against experimental results and a good agreement between the two approaches is obtained confirming capability of peridynamics for predicting in-plane and out-of-plane failure of ice sheets.
Extracting multilayer networks from Sentinel-2 satellite image time series
Authors: Interdonato Roberto , Gaetano Raffaele , Lo Seen Danny , Roche Mathieu , Scarpa Giuseppe 
Published: January 2020

AbstractNowadays, modern Earth Observation systems continuously generate huge amounts of data. A notable example is the Sentinel-2 Earth Observation mission, developed by the European Space Agency as part of the Copernicus Programme, which supplies images from the whole planet at high spatial resolution (up to 10 m) with unprecedented revisit time (every 5 days at the equator). In this data-rich scenario, the remote sensing community is showing a growing interest toward modern supervised machine learning techniques (e.g., deep learning) to perform information extraction, often underestimating the need for reference data that this framework implies. Conversely, few attention is being devoted to the use of network analysis techniques, which can provide a set of powerful tools for unsupervised information discovery, subject to the definition of a suitable strategy to build a network-like representation of image data. The aim of this work is to provide clues on how Satellite Image Time Series can be profitably represented using complex network models, by proposing a methodology to build a multilayer network from such data. This is the first work to explore the possibility to exploit this model in the remote sensing domain. An example of community detection over the provided network in a real-case scenario for the mapping of complex land use systems is also presented, to assess the potential of this approach.
Variations in sex ratios estimated from census and survey data in Zambia, 1969–2014
Authors: Chisumpa Vesper H. , Kalindi Audrey M. 
Published: January 2020

AbstractThe sex ratio question has been an area of growing interest in population dynamics, especially in developing countries with respect to the issue of missing women, but few studies have examined this in sub-Saharan Africa. Both at birth and in the general population, sex ratios follow an expected demographic pattern in the absence of the interference of historical events affecting either males or females in a population. In Zambia, an unexpected demographic pattern of sex ratios is exhibited in census and survey data. This study used data from censuses and surveys conducted from 1969 to 2014 to examine variations in sex ratios in the Zambian population. It was found that sex ratio imbalances were largely due to data deficiencies due to age misreporting and under-enumeration. A consistent under-enumeration of young adult males in the 20–34 years age group was found. A systematic pattern of high sex ratios, above 100, for ages 40+ was found, represented by synthetic cohorts traceable from the 1969 census, progressing to the 2000 census and phased out in the 2010 census. Extremely high adult male mortality was found in 2010 in the 35–59 years age group, primarily attributable to HIV/AIDS. Understanding the demographic pattern of sex ratios in a population is relevant for policies to improve the quality of data collection systems, and socioeconomic development planning, for the young age group population, which is prone under-enumeration.
The role of smartphone applications in clinical practice: a review
Authors: Wallace J , Kanegaonkar R 
Published: January 2020

AbstractObjectiveThe number of medical mobile phone applications continues to grow. Although otorhinolaryngology-specific applications represent a small proportion, there are exciting innovations emerging for the specialty. This article will assess the number of applications available and review how they may be used in clinical practice.MethodThe application stores of the two most popular mobile phone platforms, Apple and android, were searched using multiple search terms.ResultsA total of 107 ENT applications were identified and categorised according to intended use. Eight applications were reviewed in more detail and assessed on whether a doctor or allied health professional was involved in their design and if they were evidence-based.ConclusionThere are a number of ENT-specific smartphone applications currently available. As the technology progresses, their scope has extended beyond being purely for reference. Nevertheless, it remains difficult to assess the validity and security of these applications.
The aspiring developmental state and business associations in Ethiopia – (dis-)embedded autonomy?
Authors: Pellerin Camille Louise 
Published: January 2020

AbstractThis article investigates how the Ethiopian People's Revolutionary Democratic Front's (EPRDF) attempt to build a developmental state influenced and shaped its relationships with the Ethiopian private sector. Through a case study of the chambers of commerce system in Ethiopia, the research reveals that the EPRDF's relationship to the private sector was characterised by the twin objectives of (1) curbing the private sector's power to prevent challenges to the EPRDF rule and (2) mobilising the private sector as part of the ruling coalition's developmental state programme. However, these twin objectives, were, in several cases, perceived as mutually exclusive by the EPRDF which, at times, led to a focus on control at the expense of developmental objectives. The ensuing lack of embeddedness posed problems for the operationalisation of the developmental state policies, reducing the EPRDF's ability to institutionalise collaborative relationships with the private sector.
Comparison between self-administered depression questionnaires and patients' own views of changes in their mood: a prospective cohort study in primary care
Authors: Hobbs Catherine , Lewis Gemma , Dowrick Christopher , Kounali Daphne , Peters Tim J. , Lewis Glyn 
Published: January 2020

AbstractBackgroundSelf-administered questionnaires are widely used in primary care and other clinical settings to assess the severity of depressive symptoms and monitor treatment outcomes. Qualitative studies have found that changes in questionnaire scores might not fully capture patients' experience of changes in their mood but there are no quantitative studies of this issue. We examined the extent to which changes in scores from depression questionnaires disagreed with primary care patients' perceptions of changes in their mood and investigated factors influencing this relationship.MethodsProspective cohort study assessing patients on four occasions, 2 weeks apart. Patients (N = 554) were recruited from primary care surgeries in three UK sites (Bristol, Liverpool and York) and had reported depressive symptoms or low mood in the past year [68% female, mean age 48.3 (s.d. 12.6)]. Main outcome measures were changes in scores on patient health questionnaire (PHQ-9) and beck depression inventory (BDI-II) and the patients' own ratings of change.ResultsThere was marked disagreement between clinically important changes in questionnaire scores and patient-rated change, with disagreement of 51% (95% CI 46–55%) on PHQ-9 and 55% (95% CI 51–60%) on BDI-II. Patients with more severe anxiety were less likely, and those with better mental and physical health-related quality of life were more likely, to report feeling better, having controlled for depression scores.ConclusionsOur results illustrate the limitations of self-reported depression scales to assess clinical change. Clinicians should be cautious in interpreting changes in questionnaire scores without further clinical assessment.