bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the cause of hypotension? A rare complication of percutaneous coronary intervention of a chronic total occlusion: a case report
Authors: Vetrugno Vincenzo , Sharma Harish , Townend Jonathan N , Khan Sohail Q 
Published: October 2019

Abstract

Background
In the last few years, complex techniques and advanced equipment became available to treat chronically occluded coronary arteries. Such procedures portend a series of possible complications that operators should be ready to quickly recognize and deal with.

Case summary
A 75-year-old lady with uncontrolled stable angina underwent percutaneous treatment of a chronically occluded right coronary artery. After balloon angioplasty and stenting, she developed a severe hypotension, refractory to fluid resuscitation and vasopressors. Computerized tomography scan demonstrated an intramural haematoma (IMH) of the right atrioventricular groove resulting in life-threatening pseudotamponade (or dry tamponade), as further confirmed by cardiac magnetic resonance imaging (MRI). The decision was for conservative management and haemodynamic support by intra-aortic balloon pump. Clinically, the patient improved and was discharged a few days later. Follow-up MRI confirmed resolution of the IMH.

Discussion
Severe hypotension during percutaneous treatment of chronically occluded coronary arteries may be related to various causes. Differential diagnosis is thus important in this setting and should include IMH, a rare but potentially fatal complication as it may cause compression of cardiac chambers and lead to pseudotamponade. A high index of suspicion is required to diagnose IMH but there are no clear guidelines for management of such cases.
Undetected displacement of a subcutaneous implantable cardioverter-defibrillator lead. importance of performing a chest X-ray during the first weeks post-implant: a case report
Authors: Apolo Jose , San Antonio Rodolfo , Mont Lluís , Tolosana José María 
Published: October 2019

Abstract

Background
In recent years, subcutaneous implantable cardioverter-defibrillator (S-ICD) implants have progressively increased and have been shown to be safe and highly successful, affording low reintervention rates regardless of the technique used.

Case summary
We present a case of S-ICD implantation in a patient diagnosed with idiopathic ventricular fibrillation. In the first follow-up consultation the patient showed appropriate detection parameters in the three configurations. However, chest X-ray revealed lead displacement with a tip migration from the manubrium area of the sternum to the xiphoid process.

Discussion
This case highlights the importance of performing at least one chest X-ray during the first weeks after S-ICD implantation, allowing the detection of a problem such as lead displacement, which can lead to undersensing of ventricular arrhythmias or S-ICD oversensing.
Demand and supply of agricultural ES: towards benefit-based policy
Authors: Tienhaara Annika , Haltia Emmi , Pouta Eija , Arovuori Kyösti , Grammatikopoulou Ioanna , Miettinen Antti , Koikkalainen Kauko , Ahtiainen Heini , Artell Janne 
Published: October 2019

AbstractIn order to integrate ecosystem services (ES) in designing agri-environmental policy, we investigated both the demand for, and supply of, ES from agricultural environments in Finland. Using the discrete choice experiment method, we measured citizens’ willingness to pay (WTP) for four different ES and analysed farmers’ compensation request (willingness to accept [WTA]) for producing these services. Biodiversity and water quality gathered the highest WTA of farmers, but also the highest WTP of citizens. Overall, the average WTA exceeded the WTP for almost all attributes and levels, but 20–27 per cent of farmers were willing to produce the ES with the compensation lower than citizens’ WTP.
Stability of anticholinergic load in Australian community-dwelling older people: a longitudinal analysis
Authors: Mate Karen E , Barnett Michelle , Kerr Karen P , Pond C Dimity , Magin Parker J 
Published: October 2019

AbstractBackgroundIt is recommended that anticholinergic medication is avoided in older people, especially those with cognitive impairment.ObjectiveTo investigate anticholinergic load (ACL) over time in older primary care patients with and without cognitive impairment.MethodsCommunity-dwelling general practice patients at baseline (n = 1768), at year one (n = 1373) and a restricted cohort (with possible or definite cognitive impairment) at year two (n = 370) had medication regimens documented by a research nurse during a home visit. Anticholinergic medicines were categorized as levels 1–3 (low-high potency) and summed for each participant as a measure of their ACL.ResultsMost participants had no change in ACL over time, but there was some turnover in the anticholinergic medications used. The mean change in ACL was 0.012 ± 0.99 from baseline to 12 months and −0.04 ± 1.3 from baseline to 24 months. Cardiovascular drugs were the most commonly used level 1 anticholinergics, followed by antidepressants and opioids. Antidepressants and urologicals were the most commonly used level 3 anticholinergics. The rate of anticholinergic deprescribing was equivalent to the rate of anticholinergic initiation, and commonly involved the level 1 drugs warfarin, furosemide and temazepam, and the level 3 drugs amitriptyline and oxybutynin. People with dementia had a higher ACL at baseline and year one compared with other participants.ConclusionACL of community-dwelling older people was very stable over time. This may represent lost opportunities for deprescribing as well as potentially inappropriate prescribing, particularly in those with cognitive impairment.
Genetic interaction between Ptc2 and protein phosphatase 4 (PP4) in the regulation of DNA damage response and virulence in Candida albicans
Authors: Feng Jia , Shan Aidi , Hu Jing , Cao Zhenyu , Lv Rui , Feng Jinrong 
Published: October 2019

ABSTRACT
In the pathogenic fungus Candida albicans, phosphoregulation of the checkpoint kinase Rad53 plays a crucial role in the filamentous growth response to genotoxic stresses. The protein phosphatase 4 (PP4) complex, containing Pph3 and either Psy2 or Psy4, is proved to play a critical role in Rad53 dephosphorylation. In previous studies, we characterized CaPtc2 (the ortholog of both Ptc2 and Ptc3 in Saccharomyces cerevisiae) as a potential DNA-damage-related protein phosphatase. In this study, we checked the genetic interaction of PTC2 with the PP4 complex in the DNA damage response pathway. The results suggest that Ptc2 shows a negative genetic interaction with Pph3, but positive genetic interaction with either Psy2 or Psy4 in response to genotoxic stress. Deletion of PTC2 alone resulted in no significant change in cell virulence, but double deletion of PTC2 PPH3 significantly decreased virulence, while double deletions of either PTC2 PSY2 or PTC2 PSY4 caused virulence levels similar to that shown by PSY2 or PSY4 single-gene deletion cells. Taken together, we propose that Ptc2 in C. albicans plays a compensatory role for Pph3 but is dependent on Psy2 and Psy4 in regulation of DNA damage and cell virulence.
Action research with parkrun UK volunteer organizers to develop inclusive strategies
Authors: Fullagar Simone , Petris Sandra , Sargent Julia , Allen Stephanie , Akhtar Muhsina , Ozakinci Gozde 
Published: October 2019

Abstract
This article addresses the challenge of promoting physical activity through a focus on equity and engaging physically inactive citizens through the development of inclusive strategies within parkrun UK—a free, volunteer-led, weekly mass community participation running event. We discuss how a UK-based action research design enabled collaboration with volunteer event organizers to understand participant experiences, constraints and develop localized inclusive practices. In contrast with ‘expert’-driven health behaviour interventions, our research pursued a ‘ground up’ approach by asking what can be learnt from the successes and challenges of organizing community events, such as parkrun UK, to promote inclusion? A modified participatory action research approach was used with four parkrun sites across England, Scotland and Northern Ireland, that involved quantitative and qualitative analysis of survey data (n = 655) that informed the process. Our analysis explored parkrunners’ and volunteer organizers’ perceptions relating to (i) the demographics of parkrun participation and (ii) actions for change in relation to the challenges of engaging marginalized groups (women, ethnic minorities, low income, older people, those with disabilities or illness). We discuss the challenges and opportunities for addressing (in)equity and inclusion through volunteer-based organizations and the implications for translating knowledge into organizational strategies.
Anastomotic Ulcers After Ileocolic Resection for Crohn’s Disease Are Common and Predict Recurrence
Authors: Hirten Robert P , Ungaro Ryan C , Castaneda Daniel , Lopatin Sarah , Sands Bruce E , Colombel Jean Frederic , Cohen Benjamin L 
Published: October 2019

Abstract

Background
Crohn’s disease recurrence after ileocolic resection is common and graded with the Rutgeerts score. There is controversy whether anastomotic ulcers represent disease recurrence and should be included in the grading system. The aim of this study was to determine the impact of anastomotic ulcers on Crohn’s disease recurrence in patients with prior ileocolic resections. Secondary aims included defining the prevalence of anastomotic ulcers, risk factors for development, and their natural history.

Methods
We conducted a retrospective cohort study of patients undergoing an ileocolic resection between 2008 and 2017 at a large academic center, with a postoperative colonoscopy assessing the neoterminal ileum and ileocolic anastomosis. The primary outcome was disease recurrence defined as endoscopic recurrence (&gt;5 ulcers in the neoterminal ileum) or need for another ileocolic resection among patients with or without an anastomotic ulcer in endoscopic remission.

Results
One hundred eighty-two subjects with Crohn’s disease and an ileocolic resection were included. Anastomotic ulcers were present in 95 (52.2%) subjects. No factors were associated with anastomotic ulcer development. One hundred eleven patients were in endoscopic remission on the first postoperative colonoscopy. On multivariable analysis, anastomotic ulcers were associated with disease recurrence (adjusted hazard ratio [aHR] 3.64; 95% CI, 1.21–10.95; P = 0.02). Sixty-six subjects with anastomotic ulcers underwent a second colonoscopy, with 31 patients (79.5%) having persistent ulcers independent of medication escalation.

Conclusion
Anastomotic ulcers occur in over half of Crohn’s disease patients after ileocolic resection. No factors are associated with their development. They are associated with Crohn’s disease recurrence and are persistent.
A Quantum Algebra Approach to Multivariate Askey–Wilson Polynomials
Authors: Groenevelt Wolter 
Published: October 2019

AbstractWe study matrix elements of a change of basis between two different bases of representations of the quantum algebra ${\mathcal{U}}_q(\mathfrak{s}\mathfrak{u}(1,1))$. The two bases, which are multivariate versions of Al-Salam–Chihara polynomials, are eigenfunctions of iterated coproducts of twisted primitive elements. The matrix elements are identified with Gasper and Rahman’s multivariate Askey–Wilson polynomials, and from this interpretation we derive their orthogonality relations. Furthermore, the matrix elements are shown to be eigenfunctions of the twisted primitive elements after a change of representation, which gives a quantum algebraic derivation of the fact that the multivariate Askey–Wilson polynomials are solutions of a multivariate bispectral $q$-difference problem.
Beyond the hinterland: exploring the international actorness of China’s Yunnan province
Authors: Liu Tianyang , Song Yao 
Published: October 2019

AbstractThe scholarly literature on paradiplomacy has tended to focus overly on subnational governments in federal systems rather than those in unitary and centralized countries. However, it is important to note that some subnational governments in these countries have been increasingly proactive in international relations (IR). This study explores the paradiplomatic activities of Yunnan, a province in the south of China which, since the early 1990s, has actively engaged in cross-border cooperation. Combining the concept of paradiplomacy with the theory of actorness, this study first argues that Yunnan has been incentivized to conduct paradiplomacy through the decision of Beijing to open China’s borders; the inefficiency of the central government in managing border-related issues; and the interprovincial competition over economic and diplomatic clouts in the Mekong subregion. Second, this study argues that Yunnan’s new external affairs powers have been consolidated by a host of new opportunities stemming from the external environment. Third, it argues that Yunnan’s new external affairs powers have enabled it to leverage two broad instruments (infrastructure development and economic statecraft) to make neighboring countries more dependent on cooperation with it. And finally, it is argued that Yunnan’s role as an IR player has been acknowledged both by neighboring countries and by Beijing.
Bridging the digital divide: Older adults’ engagement with online cinema heritage
Authors: Dibeltulo Silvia , Culhane Sarah , Treveri Gennari Daniela 
Published: October 2019

Abstract
Is there a way to ensure older adults can bridge the digital divide and engage with online cultural heritage? How can cinema-going memories encourage cross-generational engagement? This article proposes to address these issues by using the Italian Cinema Audiences research project as a case study, and specifically cinema-going memories as intangible cultural heritage (Ercole et al., 2016, Cinema heritage in Europe: preserving and sharing culture by engaging with film exhibition and audiences. Editorial. Alphaville: Journal of Film and Screen Media, 11(Summer): 1–12. Web. ISSN: 2009-4078). It aims to tackle the difficulty of engaging the older generation with the digital world, by proposing and testing new ways to resolve it. Through a mixed-methods ethnographic approach, this article investigates different strategies: the use of social media platforms; a cross-generational activity involving Historypin, a digital, user-generated archive of crowdsourced historical material; an online dedicated archive built in collaboration with the older adults involved in the project. These different solutions aim not only at increasing digital engagement among older adults, but also at furthering younger generations’ involvement in shared cultural heritage in an online context. By focusing on the memories of cinema-going in 1950s Italy, the article explores the implications of the advantages and disadvantages of these different approaches. It also tests Anja K. Leist’s research findings (2013, Social media use of older adults: a mini-review. Gerontology, 59(4): 378–84) on the key role of moderators (the younger generation) to help novice users (the older generation) in the ‘continuous engagement’ in digital environments. We conclude that in order to bridge the digital divide two components are necessary simultaneously: the creation of digital platforms in which the older generations are both curators and users, and the support of and interaction with younger generations.
Knowledge, attitudes, and practices regarding coccidioidomycosis among healthcare providers in four counties in Washington State, 2017
Authors: Hubber J , Person A , Jecha L , Flodin-Hursh D , Stiffler J , Hill H , Bassham S , McCotter O Z , Oltean H N 
Published: October 2019

AbstractCoccidioidomycosis is an emerging infection in Washington State. The epidemiology of the disease in Washington is poorly understood at present; underrecognition and underreporting of coccidioidomycosis is suspected based on reports of only severe disease. We sought to characterize healthcare provider knowledge, attitudes, and practices regarding coccidioidomycosis awareness, diagnosis, and treatment in south-central Washington. We conducted a cross-sectional survey of actively practicing healthcare providers in four counties in south-central Washington, an area recently described as endemic for Coccidioides. Survey results were used to assess awareness of reporting requirements, confidence in ability to diagnose and treat, confidence that knowledge is current, calculated knowledge score, and consideration of risk in patient population. The majority of respondents were unaware of the reporting requirement for coccidioidomycosis in Washington and further unaware that the disease had been reported in the state. Less than a third of survey respondents reported confidence in their ability to diagnose coccidioidomycosis and confidence that their knowledge is current. The majority of respondents never or rarely consider a diagnosis of coccidioidomycosis, and &lt;25% of respondents indicated a working knowledge of serologic tests for the infection. The average knowledge score for respondents was 65%. Previous education, training, or practice regarding coccidioidomycosis was the only identified predictor of confidence and consideration of risk. These data indicate the substantial need for education and training among healthcare providers in south-central Washington and support the concern that a small proportion of existing cases of coccidioidomycosis are reported to the health department.
Spiral-arm instability – III. Fragmentation of primordial protostellar discs
Authors: Inoue Shigeki , Yoshida Naoki 
Published: October 2019

ABSTRACT
We study the gravitational instability and fragmentation of primordial protostellar discs by using high-resolution cosmological hydrodynamics simulations. We follow the formation and evolution of spiral arms in protostellar discs, examine the dynamical stability, and identify a physical mechanism of secondary protostar formation. We use linear perturbation theory based on the spiral-arm instability (SAI) analysis in our previous studies. We improve the analysis by incorporating the effects of finite thickness and shearing motion of arms, and derive the physical conditions for SAI in protostellar discs. Our analysis predicts accurately the stability and the onset of arm fragmentation that is determined by the balance between self-gravity and gas pressure plus the Coriolis force. Formation of secondary and multiple protostars in the discs is explained by the SAI, which is driven by self-gravity and thus can operate without rapid gas cooling. We can also predict the typical mass of the fragments, which is found to be in good agreement with the actual masses of secondary protostars formed in the simulation.
Super-enhancers in transcriptional regulation and genome organization
Authors: Wang Xi , Cairns Murray J , Yan Jian 
Published: October 2019

AbstractGene expression is precisely controlled in a stage and cell-type-specific manner, largely through the interaction between cis-regulatory elements and their associated trans-acting factors. Where these components aggregate in promoters and enhancers, they are able to cooperate to modulate chromatin structure and support the engagement in long-range 3D superstructures that shape the dynamics of a cell's genomic architecture. Recently, the term ‘super-enhancer’ has been introduced to describe a hyper-active regulatory domain comprising a complex array of sequence elements that work together to control the key gene networks involved in cell identity. Here, we survey the unique characteristics of super-enhancers compared to other enhancer types and summarize the recent advances in our understanding of their biological role in gene regulation. In particular, we discuss their capacity to attract the formation of phase-separated condensates, and capacity to generate three-dimensional genome structures that precisely activate their target genes. We also propose a multi-stage transition model to explain the evolutionary pressure driving the development of super-enhancers in complex organisms, and highlight the potential for involvement in tumorigenesis. Finally, we discuss more broadly the role of super-enhancers in human health disorders and related potential in therapeutic interventions.
miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database
Authors: Huang Hsi-Yuan , Lin Yang-Chi-Dung , Li Jing , Huang Kai-Yao , Shrestha Sirjana , Hong Hsiao-Chin , Tang Yun , Chen Yi-Gang , Jin Chen-Nan , Yu Yuan , Xu Jia-Tong , Li Yue-Ming , Cai Xiao-Xuan , Zhou Zhen-Yu , Chen Xiao-Hang , Pei Yuan-Yuan , Hu Liang , Su Jin-Jiang , Cui Shi-Dong , Wang Fei , Xie Yue-Yang , Ding Si-Yuan , Luo Meng-Fan , Chou Chih-Hung , Chang Nai-Wen , Chen Kai-Wen , Cheng Yu-Hsiang , Wan Xin-Hong , Hsu Wen-Lian , Lee Tzong-Yi , Wei Feng-Xiang , Huang Hsien-Da 
Published: October 2019

Abstract
MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18–25 nucleotides) that negatively control expression of target genes at the post-transcriptional level. Owing to the biological significance of miRNAs, miRTarBase was developed to provide comprehensive information on experimentally validated miRNA–target interactions (MTIs). To date, the database has accumulated >13,404 validated MTIs from 11,021 articles from manual curations. In this update, a text-mining system was incorporated to enhance the recognition of MTI-related articles by adopting a scoring system. In addition, a variety of biological databases were integrated to provide information on the regulatory network of miRNAs and its expression in blood. Not only targets of miRNAs but also regulators of miRNAs are provided to users for investigating the up- and downstream regulations of miRNAs. Moreover, the number of MTIs with high-throughput experimental evidence increased remarkably (validated by CLIP-seq technology). In conclusion, these improvements promote the miRTarBase as one of the most comprehensively annotated and experimentally validated miRNA–target interaction databases. The updated version of miRTarBase is now available at http://miRTarBase.cuhk.edu.cn/.
Why does the mind wander?
Authors: Shepherd Joshua 
Published: October 2019

Abstract
I seek an explanation for the etiology and the function of mind wandering episodes. My proposal—which I call the cognitive control proposal—is that mind wandering is a form of non-conscious guidance due to cognitive control. When the agent’s current goal is deemed insufficiently rewarding, the cognitive control system initiates a search for a new, more rewarding goal. This search is the process of unintentional mind wandering. After developing the proposal, and relating it to the literature on mind wandering and on cognitive control, I discuss explanations the proposal affords, testable predictions the proposal makes, and philosophical implications the proposal has.