bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study
Authors: Ammar Mariam , Ben Mahmoud Lobna , Medhaffar Moez , Ghozzi Hanen , Sahnoun Zouheir , Hakim Ahmed , Mseddi Malek , Elloumi Moez , Zeghal Khaled 
Published: October 2019

AbstractBackgroundThis work aimed to evaluate oxidative stress in chronic myeloid leukemia (CML) patients treated with tunisian (IM) vs controls and in CML patients with resistance to IM vs patients without resistance to IM.MethodsThe study included 40 CML patients and 34 controls. Of 40 patients with CML, 26 patients were developed in resistance to IM. The oxidant/antioxidant markers were evaluated by spectrophotometric methods for all used samples.ResultsFor CML patients, increased malondialdehyde (MDA) and advanced oxidation protein products (AOPP) levels were found compared to controls (P < .001; P = .01). Higher catalase (CAT) activity (P = .048) and lower superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, reduced Glutathione (GSH) and vitamin C levels were found in CML patients (P < .001). The comparison between the resistant vs no‐resistant CML patients revealed higher MDA level (P = .02) and CAT and SOD activities in IM‐resistant patients (P = .04, P = .03). GPx activity was reduced (P = .04). Furthermore, increased mean ratio of MDA/GSH, MDA/GPx, and SOD/(GPx + CAT) was found in IM‐resistant patients as compared with no‐resistant (P = .01, P = .01, P = .035). The mean ratio of GPx/GSH in the IM‐resistant CML patients was lower than in IM no‐resistant one (P = .039). For IM‐resistant patients, we found negative correlation between MDA level and the ratio SOD/(CAT + GPx) (r = −0.46, P = .002); and positive correlation between SOD and (CAT + GPx) activities (r = 0.38, P = .06) and between GSH level and GPx activity (r = 0.53, P = .01).ConclusionsOur results have shown a highly disturbed oxidative profile in IM‐resistant CML patients as compared to no‐resistant. The H2O2 has a key role in the resistance to IM treatment.
A‐kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C‐X‐C motif) ligand 1/chemokine (C‐X‐C motif) ligand 2 in acute myeloid leukemia
Authors: Hao Xiaohong , Gu Mianmian , Sun Jie , Cong Lin 
Published: October 2019

AbstractBackgroundThis study aimed to explore the association of A‐kinase interacting protein 1 (AKIP1) with chemokine (C‐X‐C motif) ligand (CXCL) 1/CXCL2, and further investigate their correlation with clinical features and prognosis in acute myeloid leukemia (AML) patients.MethodsTotally 160 de novo AML patients were recruited, and their bone marrow samples were collected before treatment for detecting the expressions of AKIP1, CXCL1, and CXCL2 by the quantitative polymerase chain reaction. Complete remission (CR) was assessed after induction treatment, and event‐free survival (EFS) and overall survival (OS) were calculated.ResultsAKIP1 expression was positively associated with CXCL1 (P < .001) and CXCL2 expression (P < .001). AKIP1 high expression was correlated with FAB classification (P = .022), monosomal karyotype (P = .001), and poor risk stratification (P = .013), while CXCL2 high expression was associated with monosomal karyotype (P = .001). As for treatment response, AKIP1 high expression exhibited a trend to be increased in non‐CR patients compared with CR patients, while without statistical significance (P = .105). However, no correlation of CXCL1 (P = .418) or CXCL2 (P = .685) with CR achievement was observed. Most importantly, AKIP1 and CXCL1 were negatively correlated with accumulating EFS and OS (all P < .05), while CXCL2 only showed a trend to be negatively associated with accumulating EFS (P = .069) and OS (P = .055; but without statistical significance).ConclusionAKIP1 might serve as a novel biomarker for worse AML prognosis through the interaction of CXCL1/CXCL2.
Genetics professionals’ experiences of facilitating parent/child communication through the genetic clinic
Authors: Keenan Karen F. , McKee Lorna , Miedzybrodzka Zosia 
Published: October 2019

AbstractWhile guidelines advise genetic health professionals to support and encourage family communication about genetic risk, there can be professional uncertainty when advising parents about communication with children. We sought to explore genetic health professionals’ views and experiences of facilitating parent/child communication in clinical practice, particularly in relation to adult‐onset inherited conditions. Twenty‐three in‐depth interviews were conducted with United Kingdom genetic health professionals. Thematic analysis identified four main themes: offer professional involvement, encourage early disclosure, take a limited role, and challenges. Overall, our findings demonstrate a wide variation in genetic health professionals approaches to the provision of disclosure advice to parents, ranging from professionals who offered their communication skills and expertise, to those who took a limited role and reflected they were struggling, or even felt stuck. Giving tailored advice to parents about the timing of disclosure i.e. when to tell children, was a particular challenge because of the variability in children's maturity and coping styles. Nevertheless, we identified a range of strategies which were drawn upon by participants to facilitate parent/child communication in the genetic clinic. In conclusion, study results indicate that this remains a challenging and sensitive area, in which genetics professionals express a need for more resources and the clinical time to undertake this work. Further research is needed to develop and evaluate interventions which assist parent/child communication about serious inherited conditions and to help develop professionals’ confidence and skills in this area.
Physiological investigations of the influences of byproduct pathways on 3‐hydroxypropionic acid production in Klebsiella pneumoniae
Authors: Li Xiaohan , Chen Liuni , Wang Xiuling , Tian Pingfang 
Published: October 2019

AbstractKlebsiella pneumoniae can naturally synthesize 3‐hydroxypropionic acid (3‐HP), 1,3‐propanediol (1,3‐PD), and 2,3‐butanediol (2,3‐BD) from glycerol. However, biosynthesis of these industrially important chemicals is constrained by troublesome byproducts. To clarify the influences of byproducts on 3‐HP production, in this study, a total of eight byproduct‐producing enzyme genes including pmd, poxB, frdB, fumC, dhaT, ilvH, adhP, and pflB were individually deleted from the K. pneumoniae genome. The resultant eight mutants presented different levels of metabolites. In 24‐h shake‐flask cultivation, the adhP‐ and pflB‐deletion mutants produced 0.41 and 0.44 g/L 3‐HP, respectively. Notably, the adhP and pflB double deletion mutant K. pneumoniaeΔadhPΔpflB produced 1.58 g/L 3‐HP in 24‐h shake‐flask cultivation. When K. pneumoniaeΔadhPΔpflB was harnessed as a host strain to overexpress PuuC, a native aldehyde dehydrogenase (ALDH) catalyzing 3‐hydroxypropionaldehyde (3‐HPA) to 3‐HP, the resulting recombinant strain K. pneumoniaeΔadhPΔpflB(pTAC‐puuC) (pTAC‐puuC is PuuC expression vector) generated 66.91 g/L 3‐HP with a cumulative yield of 70.84% on glycerol in 60‐h bioreactor cultivation. Additionally, this strain showed 2.3‐, 5.1‐, and 0.67‐fold decrease in the concentrations of 1,3‐PD, 2,3‐BD, and acetic acid compared with the reference strain K. pneumoniae(pTAC‐puuC). These results indicated that the byproducts exerted differential impacts on the production of 3‐HP, 1,3‐PD, and 2,3‐BD. Although combinatorial elimination of byproduct pathways could reprogram glycerol flux, the enzyme 1,3‐propanediol oxidoreductase (DhaT) that catalyzes 3‐HPA to 1,3‐PD and the enzymes ALDHs, especially, PuuC are most pivotal for 3‐HP production. This study provides a deep understanding of how byproducts affect the production of 3‐HP, 1,3‐PD, and 2,3‐BD in K. pneumoniae.
Systematic Review With Meta‐Analysis of Patient‐Centered Outcomes, Comparing International Guideline–Recommended Enteral Protein Delivery With Usual Care
Authors: Fetterplace Kate , Gill Benjamin M. T. , Chapple Lee‐anne S. , Presneill Jeffrey J. , MacIsaac Christopher , Deane Adam M. 
Published: October 2019

AbstractBackgroundInternational guidelines recommend that protein be administered enterally to critically ill patients at doses between 1.2 and 2 g/kg per day Observational data indicate that patients frequently receive less protein. The aim of this systematic review was to evaluate patient‐centered outcomes with guideline‐recommended enteral protein compared with usual care.MethodsA systematic review was performed of randomized controlled trials including critically ill adult patients provided predominately enteral nutrition with mean protein at ≥1.2 g/kg per day (intervention) and <1.2 g/kg per day (comparator). Random‐effects models were applied for outcomes reported in ≥3 trials.ResultsOf 1375 abstracts, 69 full‐text articles were reviewed, and 6 trials meet the inclusion criteria, including 511 patients. The intervention group received a mean (SD) of 1.3 (0.08) g/kg per day, and the comparator group received 0.75 (0.15) g/kg per day protein. Insufficient data were available for meta‐analyses on the primary outcome (muscle mass or strength). According to our meta‐analyses, mortality at 28 days (5 studies) (risk ratio 0.92 [95% Cl 0.63–1.35], P = .66) and the durations of intensive care unit (6 studies) and hospital admission (4 studies) were similar between the intervention and comparator, with some uncertainty due to sample sizes and heterogeneity.ConclusionThere are insufficient data to conclude whether protein provision within the current international guideline recommendations improves outcomes. In a limited dataset, enteral protein intakes near the lower level of current recommendations do not appear to reduce admission duration or mortality when compared with usual care in critically ill.
A higher order uniformly convergent method for singularly perturbed parabolic turning point problems
Authors: Yadav Swati , Rai Pratima , Sharma Kapil K. 
Published: October 2019

AbstractIn this article, we study numerical approximation for a class of singularly perturbed parabolic (SPP) convection‐diffusion turning point problems. The considered SPP problem exhibits a parabolic boundary layer in the neighborhood of one of the sides of the domain. Some a priori bounds are given on the exact solution and its derivatives, which are necessary for the error analysis. A numerical scheme comprising of implicit finite difference method for time discretization on a uniform mesh and a hybrid scheme for spatial discretization on a generalized Shishkin mesh is proposed. Then Richardson extrapolation method is applied to increase the order of convergence in time direction. The resulting scheme has second‐order convergence up to a logarithmic factor in space and second‐order convergence in time. Numerical experiments are conducted to demonstrate the theoretical results and the comparative study is done with the existing schemes in literature to show better accuracy of the proposed schemes.
Quasi‐static and ratcheting properties of PEEK reinforced by carbon fibers under uniaxial and cyclic compression
Authors: Liu Zhenduo , Gao Lilan , Gao Hong 
Published: October 2019

AbstractUniaxial compression tests were carried out to investigate the mechanical properties of polyetheretherketone (PEEK) with different contents of short carbon fibers (CF). Results show that the mechanical strength of PEEK can be improved with a certain mass fraction of CF. In order to study the viscosity of PEEK, static creep tests were performed considering the effects of stress level and content of CF. It is found that CF enhances the creep resistance of PEEK and 20 wt% carbon fiber‐reinforced PEEK has the best performance. Moreover, the creep strain of the composites increases with increasing stress level. Subsequently, the ratcheting experiments under uniaxial cyclic compression with the stress‐controlled condition were conducted. It is shown that the ratcheting strain increases with increasing stress amplitude and the holding time of peak stress. However, the effects of stress rate and content of CF on ratcheting strain are opposite. Meanwhile, the dependence of ratcheting behavior on loading history was also investigated. The results show that ratcheting strain is significantly affected by loading history of stress amplitude due to cyclic hardening of the material, while the effect of loading history of stress rate on ratcheting strain is negligible.
Property improvement of nanocellulose‐reinforced proton exchange nanocomposite membrane coated with tetraethyl orthosilicate
Authors: Zhao Qi , Wei Yingcong , Ni Chuangjiang , Zhang Yumei , Liu Baijun , Sun Zhaoyan , Xie Haiming , Hu Wei , Liang Liang 
Published: October 2019

ABSTRACTStudy on proton exchange membrane (PEM) with the aim toward excellent battery performance of PEM for fuel cells has attracted increasing attention. In this work, nanocellulose (CNC) aminated by KH792 noted as NN was prepared. CNC or NN/sulfophenylated poly(ether ether ketone ketone) (sPEEKK) nanocomposite membrane (SN) or (SNN) were produced by solution mixing. SNN was further coated with tetraethyl orthosilicate (TEOS) to obtain SNNT. The properties of sPEEKK, SN, SNN, and SNNT membranes were thoroughly investigated. The proton conductivity of SN4 was 0.22 S·cm−1 at 90 °C, while a proton conductivity of 0.30 S·cm−1 was obtained for SNN4, and an even higher value of 0.36 S·cm−1 at 90 °C was obtained for the TEOS‐coated SNN4 (SNN4T). Meanwhile, SNN4T showed high thermal stability, and its Td5 was as high as 318.2 °C. Furthermore, the composite membrane coated with TEOS also presented excellent oxidative stability. The mass of SNN2T after treated in Fenton agent for 1 h at 80 °C was still retained 96.2%, and it was not fully dissolved until 11 h. It was illustrated that aminated CNC/sPEEKK nanocomposite membranes coated with TEOS is a kind of promising materials as PEMs for fuel cells. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2190–2200
Correlations between microstructure and crystallization of the fluorinated terpolymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride
Authors: Ok Salim , Hartmann Brigitte , Duran Hatice , Eickmeier Henning , Haase Markus , Scheler Ulrich , Steinhart Martin 
Published: October 2019

ABSTRACTRandom THV terpolymers consisting of tetrafluoroethylene (TFE), hexafluoropropylene (HFP), and vinylidene fluoride (VDF) are viable alternatives to polytetrafluoroethylene (PTFE) combining excellent chemical stability and thermoplastic processability. Although the properties of THV may be modified by crystallization, little is known on how crystallization is influenced by the chain microstructure of THV. We analyzed the chain microstructure of THV‐221G by solid‐state 19F NMR spectroscopy under fast magic angle spinning, revealing that THV‐221G contains 43.8 mol % TFE, 46.0 mol % VDF, and 10.2 mol % HFP. Sequence analysis revealed that the TFE units are preferentially located next to other TFE units. The HFP units, which are obstacles to crystallization because of their bulky CF3 side groups, are preferentially located next to VDF units. WAXS measurements correspondingly revealed the presence of THV‐221G crystals with PTFE‐like packing and of further THV‐221G crystal populations with widened d‐spacings caused by the incorporation of certain amounts of HFP units into the THV‐221G crystals. Under confinement imposed by the cylindrical nanopores of self‐ordered alumina, the THV‐221G melting point decreased with decreasing pore diameter. Although direct impingement of the growing THV‐221G crystals on the pore walls is unlikely, the geometric confinement limits the access of growing THV‐221G crystals to crystallizable THV‐221G chain segments. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 1402–1408
Barriers and facilitators to physical activity in men with prostate cancer: A qualitative and quantitative systematic review
Authors: Fox Louis , Wiseman Theresa , Cahill Declan , Beyer Katharina , Peat Nicola , Rammant Elke , Van Hemelrijck Mieke 
Published: October 2019

AbstractObjectiveExisting research indicates that moderate‐to‐vigorous physical activity (PA) alleviates treatment side effects and is associated with survival in men with prostate cancer. We aimed to ascertain the state of research investigating barriers and facilitators to PA in men with prostate cancer and synthesise existing qualitative research on this topic.MethodsA systematic review of qualitative and quantitative studies was conducted. MEDLINE, Embase, PsycINFO, Web of Knowledge, CINAHL, PEDro, OATD, and WorldCat were searched to June 2019 for quantitative studies investigating causes or predictors of PA or qualitative studies describing patient‐reported barriers/facilitators to PA, amongst men with prostate cancer of any stage. Thirty‐two studies (n = 17 quantitative; n = 15 qualitative) were included from 3698 screened articles.ResultsHeterogeneity and unsystematic reporting of quantitative study methods prohibited a quantitative data synthesis. Thematic synthesis of qualitative studies produced five analytical themes: individual needs by treatment pathway, self‐determination and its relationship with prostate cancer‐related events, co‐ordination and support of the clinical care team, individual preferences in discrete aspects of PA engagement style, and the potential for a bidirectional facilitative relationship between structured group PA and spontaneous peer support. Both qualitative and quantitative studies indicated incontinence as a barrier.ConclusionsUnsystematic reporting of interventions hinders a robust quantitative understanding of behavioural intervention research in this subject area. Good co‐ordination of multidisciplinary care personnel could facilitate PA, by enabling a more comprehensive approach to targeting social cognitive processes. Well‐timed intervention and access to highly individualised PA support, including optional group PA classes, seem to also be important facilitators.
Partial FeO–Fe3O4 Phase Transition Along the <111> Direction of the Cubic Crystalline Structure in Iron Oxide Nanocrystals
Authors: Testa‐Anta Martín , Rodríguez‐González Benito , Salgueiriño Verónica 
Published: October 2019

AbstractThe iron oxide nanocrystals described herein stem from a ketonic decarboxylation reaction which fosters the delivery of –FeO– as an intermedium product. This intermedium product working as a monomer nucleates into FeO seeds which grow to attain a cubic shape with tips. This kinetically‐controlled second stage of growth favors the deposition of –FeO– at the apexes and promotes a partial topochemical FeO to Fe3O4 phase transition mainly along the elongated <111> direction of the cubic crystalline structure.
Searching heterogeneous personal digital traces
Authors: Vianna Daniela , Kalokyri Varvara , Borgida Alexander , Marian Amélie , Nguyen Thu 
Published: October 2019

ABSTRACTDigital traces of our lives are now constantly produced by various connected devices, internet services and interactions. Our actions result in a multitude of heterogeneous data objects, or traces, kept in various locations in the cloud or on local devices. Users have very few tools to organize, understand, and search the digital traces they produce. We propose a simple but flexible data model to aggregate, organize, and find personal information within a collection of a user's personal digital traces. Our model uses as basic dimensions the six questions: what, when, where, who, why, and how. These natural questions model universal aspects of a personal data collection and serve as unifying features of each personal data object, regardless of its source. We propose indexing and search techniques to aid users in searching for their past information in their unified personal digital data sets using our model. Experiments performed over real user data from a variety of data sources such as Facebook, Dropbox, and Gmail show that our approach significantly improves search accuracy when compared with traditional search tools.
How do parents of children with ASD use information grounds to seek for ASD‐related information?
Authors: An Jiaxin , Na Ying , Zhang Pengyi 
Published: October 2019

ABSTRACTParents of children with an autism spectrum disorder (ASD) have special needs about health information related to children. This research aims to understand how parents of children with ASD in China seek information in information grounds. We conducted field observations at a treatment and rehabilitation center, and interviewed 16 Chinese parents of children with ASD whose children participated in the therapy classes at this center. Results derived from qualitative coding and analysis suggest that: (1) parents' information needs evolve around improving their children's living skills, social connections are important information sources for them. (2) Parents' information grounds are closely related to their everyday life of looking after the children, such as classes and activities. Main topics of information sharing and exchange at such places include experiences of raising children with special needs, children's health status, and other child‐bearing topics. (3) Factors influencing parents' information behavior in the information grounds include homogeneity, familiarity, focal activity, reward expectation, and so on. (4) Parents benefit from such information grounds to gain useful information, emotional support, and social connections. These findings provide insights on better understanding the unique needs of parents with ASD children.
Protein adaptation to high hydrostatic pressure: Computational analysis of the structural proteome
Authors: Avagyan Samvel , Vasilchuk Daniel , Makhatadze George I. 
Published: October 2019

AbstractHydrostatic pressure has a vital role in the biological adaptation of the piezophiles, organisms that live under high hydrostatic pressure. However, the mechanisms by which piezophiles are able to adapt their proteins to high hydrostatic pressure is not well understood. One proposed hypothesis is that the volume changes of unfolding (ΔVTot) for proteins from piezophiles is distinct from those of nonpiezophilic organisms. Since ΔVTot defines pressure dependence of stability, we performed a comprehensive computational analysis of this property for proteins from piezophilic and nonpiezophilic organisms. In addition, we experimentally measured the ΔVTot of acylphosphatases and thioredoxins belonging to piezophilic and nonpiezophilic organisms. Based on this analysis we concluded that there is no difference in ΔVTot for proteins from piezophilic and nonpiezophilic organisms. Finally, we put forward the hypothesis that increased concentrations of osmolytes can provide a systemic increase in pressure stability of proteins from piezophilic organisms and provide experimental thermodynamic evidence in support of this hypothesis.