bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geographic variation in body size among French populations of the European pond turtle
Authors: Mignet Fabien , Barnagaud Jean-Yves , Barthe Laurent , Bertolero Albert , Bosc Valérie , Escot Florine , Fleuriau Romain , Joubert Laurent , Joyeux André , Lerat Damien , Massez Grégoire , Olivier Anthony , Owen-Jones Zoey , Perrot Kathleen , Petit Jérémiah , Poitevin Françoise , Poulet Laetitia , Priol Pauline , Rivière Vincent , Roy Cédric , Scher Olivier , Schwartz Timothée , Thienpont Stéphanie , Thirion Jean-Marc , Vollot Benjamin , Cheylan Marc 
Published: October 2020

Abstract
The processes underlying macroecological gradients in body size are widely debated, in part because their intraspecific variability remains poorly described even in well-studied taxa such as vertebrates. In this study, we investigated how climate, habitat, genetic lineage and sex explain body size variations in French populations of the European pond turtle (Emys orbicularis). We measured 7016 adult individuals captured in 41 populations, covering most of the species’ distribution in metropolitan France, including Corsica. Body size variation in our sample was wide and comparable to that found across the species’ worldwide range. Variation was similar in magnitude at regional and local levels, suggesting that body size is influenced by local factors as much as by regional factors such as climate or genetic lineage. Smaller sizes were associated with Mediterranean or altered oceanic climates, and with two lineages (E. o. galloitalica and E. o. galloitalica/E. o. orbicularis), while larger sizes were associated with northern environments and the orbicularis lineage. Body size variations recorded at local level reflect an adaptive response to environmental constraints, suggesting that habitat is also an important factor in understanding size variation.
Il ruolo della prefazione nei testi grammaticali latini: un addendum
Authors: Munzi Luigi 
Published: October 2020

Abstract
Conceived as an Appendix to Il ruolo della prefazione nei testi grammaticali latini (AIONfilol 14, 1992, 103–126), this paper offers a selection of texts and loci similes related to the metaphoric and literary topic exploited in prologues and prefaces of Latin grammatical texts dated between late Antiquity and early Middle Ages (4th–9th cent.).
Rethinking the Chongqing Negotiations of 1945: Concession-making, the Trust/distrust Paradox, and the Biased Mediator in China’s Post-war Transitions
Authors: Cheng Victor Shiu Chiang 
Published: October 2020

Abstract
This article rethinks what are perhaps the most important attempts at making peace in modern Chinese history: the first post-World War II peace talks convened in Chongqing, between the two old foes of the Chinese Civil War. Previous studies treat the peace conference as a sideshow to the subsequent full-scale civil war. Examining the political and military situation in China toward the end of World War II, this article argues that a peace agreement was needed for both parties. The core of the article examines the hitherto unexplored aspects around the negotiating table: the debate, disagreements, and compromises, and the American mediator’s attempt to alter the dynamics of the peace talks from an inherently biased position. It finds that the history of the Chongqing negotiations is more important to our understanding of China’s struggle between peace and war in the modern era than previously acknowledged.
Grapheme–Color Synesthesia in an Abugida: a Bengali Case Study
Authors: Root Nicholas , Bhattacharyya Pushpita , Ramachandran Vilayanur S. 
Published: October 2020

Abstract
Grapheme–color synesthetes experience graphemes (e.g., letters of the alphabet) as having a specific, consistent color. Most studies of grapheme–color synesthesia have only examined synesthetes in English, leaving underexplored the question of how synesthetic phenomenology might differ in languages that do not use alphabets. In particular, grapheme–color synesthesia in an abugida (a segmental writing system in which vowels are added to consonant graphemes using ‘accent’-like diacritical marks) has never been studied. Here, we present a case study of a Bengali synesthete, MJ, the first report of a grapheme–color synesthete in an abugida. First, we show that for MJ, diacritics influence the overall color of the consonant grapheme they modify, ‘pulling’ it toward the color she experiences for the vowel. Second, we describe and analyze the complex synesthetic experiences reported by MJ for conjunct graphemes, a unique orthographic feature of Brahmi-derived scripts (such as Bengali) in which multiple graphemes are visually combined into a single ‘merged’ grapheme. Finally, we show that in addition to these language-specific features, MJ’s synesthetic associations are influenced by some of the same linguistic properties (such as orthography and phonology) that influence synesthetic associations in other languages. We conclude that the idiosyncratic features of MJ’s synesthesia reflect unique properties of the Bengali writing system, that more studies of synesthesia in non-alphabetic scripts are needed, and that synesthetic phenomenology can offer insights into how linguistic properties shape grapheme representation in the brain.
Extending the Body Ownership to Affective Experience of an Embodied Artificial Hand: a Power Spectra Investigation
Authors: Crivelli Davide , Balconi Michela 
Published: October 2020

Abstract
According to implicit accounts, human self-awareness grounds on the so-called sense of ownership (SoO). Empirical investigations of SoO have mostly focused on the manipulation of self-ascription of sensations and experiences involving the body via the induction of bodily illusions, such as the Rubber-Hand Illusion (RHI). While it has been proposed that the affective dimension necessarily contributes to the development of a full ownership ascription, the relationship between affective experience and body ownership still presents many open questions. This study thus aimed at investigating the boundaries of ownership ascriptions and the extent to which an external object can be incorporated within one’s own body representation, with a specific focus on the possibility for it to become a potential object of own affective experience marked by specific electrophysiological responses. Therefore, we induced RHI in 16 participants and then applied an aversive vs. pleasant stimulation to the embodied external object, while monitoring their electrophysiological activity for central physiological markers of affective processing. Data analysis revealed the effect of the stimulation condition on alpha band power over frontal areas, with higher alpha power during the pleasant stimulation condition with respect to the aversive stimulation one over medial and right frontal electrode sites. The present findings add to the limited pieces of evidence concerning the link between experiences of illusory body ownership, embodiment mechanisms, and affective factors, suggesting that the boundaries of body ownership might be extended to making incorporated objects the source of complex emotional responses beyond basic defensive reactions.
A new crab-associated amphipod of the genus Isaeopsis Barnard, 1916 (Amphipoda: Senticaudata: Ischyroceridae) from southern Chile
Authors: PÉREZ-SCHULTHEISS JORGE , PARDO LUIS MIGUEL 
Published: October 2020

A new species of amphipod of the family Ischyroceridae is described. Isaeopsis chiloensis n. sp. was discovered in association with the cancrid species Metacarcinus edwardsii and Romaleon setosum, in the inner sea around Chiloé Island, in Southern Chile. This represents the second species of the genus Isaeopsis, a group formerly known only from South African waters. The new species is characterized principally by the structure of the gnathopods, the propodus of pereopods 3–7 and the ornamentation of the outer ramus of uropod 3. The male gnathopod 2 has a prominent thumb in the posteroproximal margin of the propodus and the pereopods 3–7 are subchelate with the palm armed by a row of at least five strong setae. In addition, the apex of the outer ramus of uropod 3 bears a comb with more than thirty fine teeth. Isaeopsis chiloensis n. sp. is completely described and a series of illustrations is provided.
Lifetime radiation risk of stochastic effects – prospective evaluation for space flight or medicine
Authors: Ulanowski A. , Kaiser J.C. , Schneider U. , Walsh L. 
Published: October 2020

The concept of lifetime radiation risk of stochastic detrimental health outcomes is important in contemporary radiation protection, being used either to calculate detriment-weighted effective dose or to express risks following radiation accidents or medical uses of radiation. The conventionally applied time-integrated risks of radiation exposure are computed using average values of current population and health statistical data that need to be projected far into the future. By definition, the lifetime attributable risk (AR) is an approximation to more general lifetime risk quantities and is only valid for exposures under 1 Gy. The more general quantities, such as excess lifetime risk (ELR) and risk of exposure-induced cancer, are free of dose range constraints, but rely on assumptions concerning the unknown total radiation effect on demographic and health statistical data, and are more computationally complex than AR. Consideration of highly uncertain competing risks for other radiation-attributed outcomes are required in appropriate assessments of time-integrated risks of specific outcomes following high-dose (>1 Gy) exposures, causing non-linear dose responses in the resulting ELR estimate. Being based on the current population and health statistical data, the conventionally applied time-integrated risks of radiation exposure are: (i) not well suited for projections many years into the future because of the large uncertainties in future secular trends in the population-specific disease rates; and (ii) not optimal for application to atypical groups of exposed persons not well represented by the general population. Specifically, medical patients are atypical in this respect because their prospective risks depend strongly on the original diagnosis, the treatment modality, general cure rates, individual radiation sensitivity, and genetic predisposition. Another situation challenging the application of conventional risk quantities is a projection of occupational radiation risks associated with space flight, both due to higher radiation doses and astronauts’ generally excellent health condition due to pre-selection, training, and intensive medical screening. An alternative quantity, named ‘radiation-attributed decrease of survival’ (RADS), known in past general statistical literature as ‘cumulative risk’, is recommended here for applications in space and medicine to represent the cumulative radiation risk conditional on survival until a certain age. RADS is only based on the radiation-attributed hazard rendering an insensitivity to competing risks or projections of current population statistics far into the future. Therefore, RADS is highly suitable for assessing semi-personalised radiation risks after radiation exposures from space missions or medical applications of radiation.
Return of spontaneous circulation in patients with out‐of‐hospital cardiac arrest caused by pulmonary embolism using early point‐of‐care ultrasound and timely thrombolytic agent application: Two case reports
Authors: Pyo Su Yeong , Park Gwan Jin , Kim Sang Chul , Kim Hoon , Lee Suk Woo , Lee Ji Han 
Published: October 2020

Introduction:Acute pulmonary embolism is a confirmed cause of up to 5% of out‐of‐hospital cardiac arrest and 5%–13% of unexplained cardiac arrest in patients. However, the true incidence may be much higher, as pulmonary embolism is often clinically underdiagnosed. Thrombolytic therapy is a recognized therapy for pulmonary embolism–associated cardiac arrest but is not routinely recommended during cardiopulmonary resuscitation. Therefore, clinicians should attempt to identify patients with suspected pulmonary embolism. Many point‐of care ultrasound protocols suggest diagnosis of pulmonary embolism for cardiac arrest patients.Case presentation:We describe two male patients (60 years and 66 years, respectively) who presented to the emergency department with cardiac arrest within a period of 1 week. With administration of point‐of care ultrasound during the ongoing cardiopulmonary resuscitation in both patients, fibrinolytic therapy was initiated under suspicion of cardiac arrest caused by pulmonary embolism. Both patients had return of spontaneous circulation; however, only the second patient, who received fibrinolytic therapy relatively early, was discharged with a good outcome. In this report, we discussed how to diagnose and manage patients with cardiac arrest–associated pulmonary embolism with the help of point‐of care ultrasound. We also discuss the different clinical outcomes of the two patients based on the experience of the clinicians and the timing of thrombolytic agent application.Conclusions:If acute pulmonary embolism is suspected in patients with out‐of‐hospital cardiac arrest, we recommend prompt point‐of care ultrasound examination. Point‐of care ultrasound may help identify patients with pulmonary embolism during cardiopulmonary resuscitation, leading to immediate treatment, although the clinical outcomes may vary.
An extremely rare phenomenon: Angina bullosa hemorrhagica
Authors: Demir Mehmet Cihat , Ağaçkıran İlter 
Published: October 2020

Introduction:Angina bullosa hemorrhagica is a disease without a concomitant hematological or vesiculobullous disorder characterized by painless hemorrhagic bullae in the oral mucosa; it is rarely seen and has a good course.Case presentation:A 45‐year‐old female patient was admitted to the emergency department with a painless hemorrhagic bulla that suddenly appeared on the soft palate. A blister, 2 cm in diameter and dark red in color, was seen extending from the hard palate's posterior to the soft palate. Nasolaryngoscopic evaluation was performed, and no additional hemorrhagic bulla was detected. She was discharged with the recommendation of oral mouthwash.Discussion:Solitary hemorrhagic bulla, suddenly occurring on the soft palate, is diagnostic for angina bullosa hemorrhagica. Some authors have reported that blisters in the posterior pharynx may progress to acute upper airway obstruction.Conclusion:Early nasolaryngoscopic evaluation in angina bullosa hemorrhagica is an excellent option to be considered by the emergency physician to prevent life‐threatening situations.
Proceedings From a Canadian Nephrology Forum: Nephrology Is Back
Authors: Levin Adeera , Sapir Daniel , Steele Andrew , Cherney David , Hellstrom Ian C. , Lanktree Matthew B. , Moist Louise , Suri Rita S. 
Published: October 2020

Purpose of conference: On January 18, 2020, the Nephrology is Back learning day forum was held in Toronto, ON, Canada. The objectives of the meeting were to describe recent advances in nephrology for community and academic nephrologists and patients, and to define challenges and opportunities for integration of new data into clinical practice. The intent was to test a unique forum for continuing medical education integrating physician and patient experiences with the goal of encouraging change in practice. Sources of information: Program content was based on current literature and clinical experience. Additional information was provided by patient partners who attended the meeting to provide their perspective on current issues in nephrology. Methods: A steering committee (A.L., A.S., and D.S.) developed goals and an outline for the content to be covered over the course of the meeting and led the recruitment of speakers. Speakers were asked to develop their presentations independently following direction by the committee, based on primary sources, including their own experiences. Presentations were followed by discussion including both physicians and patients, and participants had an opportunity to evaluate the conference and its outcomes. Key findings: We present a unique approach to providing continuing medical education by including both physicians and patients in the learning process. Patient perspectives accompanying presentations around data and other clinical topics provided a much different environment from other knowledge translation exercises. We believe this represents an innovative approach for knowledge translation that allows physicians to address clinical topics in a novel manner, including the integration of new findings into practice and the need to cascade this education to their peers. Limitations: Because the conference was a one-time event, it has been difficult to assess the actual clinical impact of the knowledge translation exercise and whether physician behaviors have changed as a result of the activity. The conference could also have included broader representation from across Canada. Implications: The success of this test forum among both physicians and patient partners suggests that the inclusion of patient partners in learning could have an important role in future educational initiatives.
Characterization of Ag-exchanged clinoptilolite treated with a plasma jet at atmospheric pressure
Authors: Dikmen Sedef , Şahin Neslihan , Dikmen Zafer , Tanışlı Murat 
Published: October 2020

AbstractThis study reports on the effects of dielectric barrier discharge-like (DBD-like) plasma jet treatment at atmospheric pressure on Ag cation-exchanged clinoptilolite. In the plasma treatment process, argon plasma was applied to the surface of pellet samples prepared with Ag-clinoptilolite. After DBD-like plasma jet treatment for 30 and 60 min, remarkable colour changes were observed in the pellet samples. These changes indicate that the DBD-like plasma jet application led to the successful reduction of Ag+ to its metallic forms, which was further confirmed by the results of ultraviolet–visible diffuse reflectance spectroscopy. The structural, composition and morphological properties of the DBD-like plasma jet-treated samples were characterized using Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy and energy-dispersive X-ray analyses, and they were compared to the untreated Ag-clinoptilolite. The DBD-like plasma jet treatment caused no detectable structural changes in clinoptilolite within the analytical limitations of the methods used. The FTIR spectra show that the plasma treatment causes discharge-induced functional changes in the hydroxyl stretching region. The peaks appearing in the XRD patterns confirmed the reduction of Ag+ to Ag0 after exposure to the plasma. The present study indicates that the reduction of Ag+ cations to their metallic forms can be performed successfully using the proposed method without collapsing the crystal structure of the Ag-clinoptilolite.
TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML
Authors: Vadakekolathu Jayakumar , Lai Catherine , Reeder Stephen , Church Sarah E. , Hood Tressa , Lourdusamy Anbarasu , Rettig Michael P. , Aldoss Ibrahim , Advani Anjali S. , Godwin John , Wieduwilt Matthew J. , Arellano Martha , Muth John , Yau Tung On , Ravandi Farhad , Sweet Kendra , Altmann Heidi , Foulds Gemma A. , Stölzel Friedrich , Middeke Jan Moritz , Ciciarello Marilena , Curti Antonio , Valk Peter J. M. , Löwenberg Bob , Gojo Ivana , Bornhäuser Martin , DiPersio John F. , Davidson-Moncada Jan K. , Rutella Sergio 
Published: October 2020

Abstract
Somatic TP53 mutations and 17p deletions with genomic loss of TP53 occur in 37% to 46% of acute myeloid leukemia (AML) with adverse-risk cytogenetics and correlate with primary induction failure, high risk of relapse, and dismal prognosis. Herein, we aimed to characterize the immune landscape of TP53-mutated AML and determine whether TP53 abnormalities identify a patient subgroup that may benefit from immunotherapy with flotetuzumab, an investigational CD123 × CD3 bispecific dual-affinity retargeting antibody (DART) molecule. The NanoString PanCancer IO360 assay was used to profile 64 diagnostic bone marrow (BM) samples from patients with TP53-mutated (n = 42) and TP53-wild-type (TP53-WT) AML (n = 22) and 45 BM samples from patients who received flotetuzumab for relapsed/refractory (R/R) AML (15 cases with TP53 mutations and/or 17p deletion). The comparison between TP53-mutated and TP53-WT primary BM samples showed higher expression of IFNG, FOXP3, immune checkpoints, markers of immune senescence, and phosphatidylinositol 3-kinase-Akt and NF-κB signaling intermediates in the former cohort and allowed the discovery of a 34-gene immune classifier prognostic for survival in independent validation series. Finally, 7 out of 15 patients (47%) with R/R AML and TP53 abnormalities showed complete responses to flotetuzumab (&lt;5% BM blasts) on the CP-MGD006-01 clinical trial (NCT #02152956) and had significantly higher tumor inflammation signature, FOXP3, CD8, inflammatory chemokine, and PD1 gene expression scores at baseline compared with nonresponders. Patients with TP53 abnormalities who achieved a complete response experienced prolonged survival (median, 10.3 months; range, 3.3-21.3 months). These results encourage further study of flotetuzumab immunotherapy in patients with TP53-mutated AML.