bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence for suffix cohesion in French
Authors: Storme Benjamin 
Published: September 2020

ABSTRACTIn a language, suffix cohesion refers to the fact that suffixed words behave phonologically as simple or complex units depending on the suffix they are built with. This article uncovers a previously undescribed pattern of suffix cohesion in French, where words suffixed with vowel- and glide-initial suffixes behave phonologically like simple units (e.g.fêtiez[fet-je] ‘you partied’) and words built with other consonant-initial suffixes behave phonologically like complex units (e.g.fêterez[fɛt-ʁe] ‘you will party’). The evidence comes from a reassessment of well-known data on [ə]–[ɛ] stem alternations and from an acoustic study of [e]–[ɛ] and [o]–[ɔ] alternations in suffixed words as pronounced by 10 speakers living in the Paris area. The suffix’s phonological shape is found to provide the best account of the data among a set of factors that have been argued to be relevant to suffix cohesion in other languages (in particular resyllabification). The French pattern has important theoretical implications for theories of suffix cohesion as it is not prosodically conditioned. An alternative analysis in terms of paradigm uniformity is proposed, where suffixed words are treated as complex units phonologically if the suffix’s phonological shape facilitates the perceptual recognition of the base corresponding to the suffixed word’s stem.
Analysing Fuel Subsidy and Taxation Reform with Input–Output Data
Authors: Beutel Joerg 
Published: September 2020

AbstractFor a long time, the use of intermediate products in production has been growing more rapidly in most countries than domestic production. This is a strong indication of more interdependency in production. The main purpose of input-output analysis is to study the interdependency of industries in an economy. Often the term interindustry analysis is also used. Therefore, the exchange of intermediate products is a key issue of input-output analysis. We will use input–output data for this study that the author prepared for the new ‘Handbook on Supply, Use and Input–Output Tables with Extensions and Applications’ of the United Nations. The supply use and input–output tables contain separate valuation matrices for trade margins, transport margins, value added tax, other taxes on products and subsidies on products. For the study, two input–output models were developed to evaluate the impact of fuel subsidy and taxation reform on output, gross domestic product, inflation and trade. Six scenarios are discussed covering different aspects of the reform.
A small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1− pre-B-ALL
Authors: Wang Zhihua , Zhang Yang , Zhu Shicong , Peng Hongling , Chen Yongheng , Cheng Zhao , Liu Sufang , Luo Yunya , Li Ruijuan , Deng Mingyang , Xu Yunxiao , Hu Guoyu , Chen Lin , Zhang Guangsen 
Published: September 2020

AbstractHistone deacetylase 7 (HDAC7), a member of class IIa HDACs, has been described to be an important regulator for B cell development and has a potential role in B cell acute lymphoblastic leukemia (B-ALL). CC1007, a BML-210 analog, is designed to indirectly inhibit class IIa HDACs by binding to myocyte enhancer factor-2 (MEF2) and blocking the recruitment of class IIa HDACs to MEF2-targeted genes to enhance the expression of these targets. In this study, we investigated the anticancer effects of CC1007 in breakpoint cluster region-Abelson 1 fusion gene-negative (BCR-ABL1−) pre-B-ALL cell lines and primary patient-derived BCR-ABL1− pre-B-ALL cells. CC1007 had obvious antileukemic activity toward pre-B-ALL cells in vitro and in vivo; it also significantly prolonged median survival time of pre-B-ALL-bearing mice. Interestingly, low dose of CC1007 could inhibit proliferation of BCR-ABL1− pre-B-ALL cells in a time-dependent manner not accompanied by significant cell apoptosis, but along with cross-lineage differentiation toward monocytic lineage. From a mechanistic angle, we showed that HDAC7 was overexpressed in BCR-ABL1− pre-B-ALL cells compared to normal bone marrow samples, and CC1007 could reduce the binding of HDAC7 at the promoters of monocyte–macrophage-specific genes via inhibition of HDAC7 expression and HDAC7:MEF2C interaction. These data indicated that CC1007 may be a promising agent for the treatment of BCR-ABL1− pre-B-ALL.
Large scale in silico characterization of repeat expansion variation in human genomes
Authors: Fazal Sarah , Danzi Matt C. , Cintra Vivian P. , Bis-Brewer Dana M. , Dolzhenko Egor , Eberle Michael A. , Zuchner Stephan 
Published: September 2020

AbstractSignificant progress has been made in elucidating single nucleotide polymorphism diversity in the human population. However, the majority of the variation space in the genome is structural and remains partially elusive. One form of structural variation is tandem repeats (TRs). Expansion of TRs are responsible for over 40 diseases, but we hypothesize these represent only a fraction of the pathogenic repeat expansions that exist. Here we characterize long or expanded TR variation in 1,115 human genomes as well as a replication cohort of 2,504 genomes, identified using ExpansionHunter Denovo. We found that individual genomes typically harbor several rare, large TRs, generally in non-coding regions of the genome. We noticed that these large TRs are enriched in their proximity to Alu elements. The vast majority of these large TRs seem to be expansions of smaller TRs that are already present in the reference genome. We are providing this TR profile as a resource for comparison to undiagnosed rare disease genomes in order to detect novel disease-causing repeat expansions.
Robust formation of amorphous Sb2S3 on functionalized graphene for high-performance optoelectronic devices in the cyan-gap
Authors: Chen Ju-Hung , Chiu Sheng-Kuei , Luo Jin-De , Huang Shu-Yu , Ting Hsiang-An , Hofmann Mario , Hsieh Ya-Ping , Ting Chu-Chi 
Published: September 2020

AbstractDespite significant progress in the fabrication and application of semiconductor materials for optical emitters and sensors, few materials can cover the cyan-gap between 450 and 500 nm. We here introduce a robust and facile method to deposit amorphous Sb2S3 films with a bandgap of 2.8 eV. By exploiting the tunable functionality of graphene, a two-dimensional material, efficient deposition from a chemical was achieved. Ozone-generated defects in the graphene were shown to be required to enhance the morphology and quality of the material and comprehensive characterization of the seed layer and the Sb2S3 film were applied to design an optimal deposition process. The resulting material exhibits efficient carrier transport and high photodetector performance as evidenced by unprecedented responsivity and detectivity in semiconductor/graphene/glass vertical heterostructures. (112 A/W, 2.01 × 1012 Jones, respectively).
Mechanically facilitated micro-fluid mixing in the organ of Corti
Authors: Shokrian Mohammad , Knox Catherine , Kelley Douglas H. , Nam Jong-Hoon 
Published: September 2020

AbstractThe cochlea is filled with two lymphatic fluids. Homeostasis of the cochlear fluids is essential for healthy hearing. The sensory epithelium called the organ of Corti separates the two fluids. Corti fluid space, extracellular fluid space within the organ of Corti, looks like a slender micro-tube. Substantial potassium ions are constantly released into the Corti fluid by sensory receptor cells. Excess potassium ions in the Corti fluid are resorbed by supporting cells to maintain fluid homeostasis. Through computational simulations, we investigated fluid mixing within the Corti fluid space. Two assumptions were made: first, there exists a longitudinal gradient of potassium ion concentration; second, outer hair cell motility causes organ of Corti deformations that alter the cross-sectional area of the Corti fluid space. We hypothesized that mechanical agitations can accelerate longitudinal mixing of Corti fluid. Corti fluid motion was determined by solving the Navier–Stokes equations incorporating nonlinear advection term. Advection–diffusion equation determined the mixing dynamics. Simulating traveling boundary waves, we found that advection and diffusion caused comparable mixing when the wave amplitude and speed were 25 nm and 7 m/s, respectively. Higher-amplitude and faster waves caused stronger advection. When physiological traveling waves corresponding to 70 dB sound pressure level at 9 kHz were simulated, advection speed was as large as 1 mm/s in the region basal to the peak responding location. Such physiological agitation accelerated longitudinal mixing by more than an order of magnitude, compared to pure diffusion. Our results suggest that fluid motion due to outer hair cell motility can help maintain longitudinal homeostasis of the Corti fluid.
Spatial separation of degenerate components of magnon Bose–Einstein condensate by using a local acceleration potential
Authors: Borisenko I. V. , Demidov V. E. , Pokrovsky V. L. , Demokritov S. O. 
Published: September 2020

AbstractBose–Einstein condensation (BEC) of magnons is one of the few macroscopic quantum phenomena observable at room temperature. Due to the competition of the exchange and the magnetic dipole interactions, the minimum-energy magnon state is doubly degenerate and corresponds to two antiparallel non-zero wavevectors. Correspondingly, the room-temperature magnon BEC differs essentially from other condensates, since it takes place simultaneously at ± kmin. The degeneracy of BEC and interaction between its two components have significant impact on condensate properties. Phase locking of the two condensates causes formation of a standing wave of the condensate density and quantized vortices. Additionally, interaction between the two components is believed to be important for stabilization of the condensate with respect to a real-space collapse. Thus, the possibility to create a non-degenerate, single-component condensate is decisive for understanding of underlying physics of magnon BEC. Here, we experimentally demonstrate an approach, which allows one to accomplish this challenging task. We show that this can be achieved by using a separation of the two components of the degenerate condensate in the real space by applying a local pulsed magnetic field, which causes their motion in the opposite directions. Thus, after a certain delay, the two clouds corresponding to different components become well separated in the real space. We find that motion of the clouds can be described well based on the peculiarities of magnon dispersion characteristics. Additionally, we show that, during the motion, the condensate cloud harvests non-condensed magnons, which results in a partial compensation of condensate depletion.
Silence as a way of niche adaptation: mecC-MRSA with variations in the accessory gene regulator (agr) functionality express kaleidoscopic phenotypes
Authors: Huber Charlotte , Stamm Ivonne , Ziebuhr Wilma , Marincola Gabriella , Bischoff Markus , Strommenger Birgit , Jaschkowitz Greta , Marciniak Tessa , Cuny Christiane , Witte Wolfgang , Doellinger Joerg , Schaudinn Christoph , Thürmer Andrea , Epping Lennard , Semmler Torsten , Lübke-Becker Antina , Wieler Lothar H. , Walther Birgit 
Published: September 2020

AbstractFunctionality of the accessory gene regulator (agr) quorum sensing system is an important factor promoting either acute or chronic infections by the notorious opportunistic human and veterinary pathogen Staphylococcus aureus. Spontaneous alterations of the agr system are known to frequently occur in human healthcare-associated S. aureus lineages. However, data on agr integrity and function are sparse regarding other major clonal lineages. Here we report on the agr system functionality and activity level in mecC-carrying methicillin resistant S. aureus (MRSA) of various animal origins (n = 33) obtained in Europe as well as in closely related human isolates (n = 12). Whole genome analysis assigned all isolates to four clonal complexes (CC) with distinct agr types (CC599 agr I, CC49 agr II, CC130 agr III and CC1943 agr IV). Agr functionality was assessed by a combination of phenotypic assays and proteome analysis. In each CC, isolates with varying agr activity levels were detected, including the presence of completely non-functional variants. Genomic comparison of the agr I–IV encoding regions associated these phenotypic differences with variations in the agrA and agrC genes. The genomic changes were detected independently in divergent lineages, suggesting that agr variation might foster viability and adaptation of emerging MRSA lineages to distinct ecological niches.
Self-defect-passivation by Br-enrichment in FA-doped Cs1−xFAxPbBr3 quantum dots: towards high-performance quantum dot light-emitting diodes
Authors: Park Young Ran , Eom Sangwon , Kim Hong Hee , Choi Won Kook , Kang Youngjong 
Published: September 2020

AbstractHalide vacancy defect is one of the major origins of non-radiative recombination in the lead halide perovskite light emitting devices (LEDs). Hence the defect passivation is highly demanded for the high-performance perovskite LEDs. Here, we demonstrated that FA doping led to the enrichment of Br in Cs1−xFAxPbBr3 QDs. Due to the defect passivation by the enriched Br, the trap density in Cs1−xFAxPbBr3 significantly decreased after FA doping, and which improved the optical properties of Cs1−xFAxPbBr3 QDs and their QD-LEDs. PLQY of Cs1–xFAxPbBr3 QDs increased from 76.8% (x = 0) to 85.1% (x = 0.04), and Lmax and CEmax of Cs1–xFAxPbBr3 QD-LEDs were improved from Lmax = 2880 cd m−2 and CEmax = 1.98 cd A−1 (x = 0) to Lmax = 5200 cd m−2 and CEmax = 3.87 cd A−1 (x = 0.04). Cs1–xFAxPbBr3 QD-LED device structure was optimized by using PVK as a HTL and ZnO modified with b-PEI as an ETL. The energy band diagram of Cs1–xFAxPbBr3 QD-LEDs deduced by UPS analyses.
Chronic neural activity recorded within breast tumors
Authors: McCallum Grant A. , Shiralkar Jay , Suciu Diana , Covarrubias Gil , Yu Jennifer S. , Karathanasis Efstathios , Durand Dominique M. 
Published: September 2020

AbstractNerve fibers are known to reside within malignant tumors and the greater the neuronal density the worse prognosis for the patient. Recent discoveries using tumor bearing animal models have eluded to the autonomic nervous system having a direct effect on tumor growth and metastasis. We report the first direct and chronic in vivo measurements of neural activity within tumors. Using a triple-negative mammary cancer mouse model and chronic neural interface techniques, we have recorded neural activity directly within the tumor mass while the tumor grows and metastasizes. The results indicate that there is a strong connection between the autonomic nervous system and the tumor and could help uncover the mechanisms of tumor growth and metastasis.
Micro-sized thin-film solar cells via area-selective electrochemical deposition for concentrator photovoltaics application
Authors: Siopa Daniel , El Hajraoui Khalil , Tombolato Sara , Babbe Finn , Lomuscio Alberto , Wolter Max H. , Anacleto Pedro , Abderrafi Kamal , Deepak Francis L. , Sadewasser Sascha , Dale Phillip J. 
Published: September 2020

AbstractMicro-concentrator solar cells enable higher power conversion efficiencies and material savings when compared to large-area non-concentrated solar cells. In this study, we use materials-efficient area-selective electrodeposition of the metallic elements, coupled with selenium reactive annealing, to form Cu(In,Ga)Se2 semiconductor absorber layers in patterned microelectrode arrays. This process achieves significant material savings of the low-abundance elements. The resulting copper-poor micro-absorber layers’ composition and homogeneity depend on the deposition charge, where higher charge leads to greater inhomogeneity in the Cu/In ratio and to a patchy presence of a CuIn5Se8 OVC phase. Photovoltaic devices show open-circuit voltages of up to 525 mV under a concentration factor of 18 ×, which is larger than other reported Cu(In,Ga)Se2 micro-solar cells fabricated by materials-efficient methods. Furthermore, a single micro-solar cell device, measured under light concentration, displayed a power conversion efficiency of 5% under a concentration factor of 33 ×. These results show the potential of the presented method to assemble micro-concentrator photovoltaic devices, which operate at higher efficiencies while using light concentration.
Demonstration and application of diffusive and ballistic wave propagation for drone-to-ground and drone-to-drone wireless communications
Authors: Burke Peter J. 
Published: September 2020

AbstractIn order to determine how an electromagnetic wave propagates from a base station to a cell phone or a wirelessly connected device, we use a novel Unmanned Aerial Vehicle (UAV) mapping technology to map the cellular network coverage at various altitudes in various terrains (flat, hilly, mountainous). For the flat terrains, the waves are shown to propagate ballistically: They have an altitude independent path loss consistent with minimal scatter in the propagation from transmitter to (aerial) receiver. In mountainous terrain, the waves are shown to propagate in the diffuse regime, and demonstrate a 10 dB increase in received signal intensity per 100′ of altitude gain, up to 400′. In the intermediate case, evidence of coherent wave interference is clearly observed in altitude independent interference patterns. These general observations can be used to build a physical or empirical model for drone-to-ground and drone-to-drone propagation, for which existing models are shown to fail. While important for building physical models of wave propagation in wireless networks, this method can be used more generally to determine the magnitude and phase of an electromagnetic wave at every point in space, as well as usher in the era of drone-to-ground and drone-to-drone communications.
High MHC-II expression in Epstein–Barr virus-associated gastric cancers suggests that tumor cells serve an important role in antigen presentation
Authors: Ghasemi Farhad , Tessier Tanner M. , Gameiro Steven F. , Maciver Allison H. , Cecchini Matthew J. , Mymryk Joe S. 
Published: September 2020

AbstractEBV-associated gastric adenocarcinomas (EBVaGCs) often exhibit better clinical outcomes than EBV negative gastric cancers (GCs), which could be related to their consistent expression of foreign viral antigens. Antigen-presenting cells (APCs) present peptide antigens in the context of the class-II major histocompatibility complex (MHC-II). During inflammatory conditions, epithelial cells express MHC-II and function as accessory APCs. Utilizing RNA-seq data from nearly 400 GC patients, we determined the impact of EBV-status on expression of MHC-II components, genes involved in their regulation, and T-cell co-stimulation. Virtually all MHC-II genes were significantly upregulated in EBVaGCs compared to normal tissues, or other GC subtypes. Genes involved in antigen presentation were also significantly upregulated in EBVaGCs, as were the key MHC-II transcriptional regulators CIITA and RFX5. This was unexpected as the EBV encoded BZLF1 protein can repress CIITA transcription and is expressed in many EBVaGCs. Furthermore, MHC-II upregulation was strongly correlated with elevated intratumoral levels of interferon-gamma. In addition, expression of co-stimulatory molecules involved in T-cell activation and survival was also significantly increased in EBVaGCs. Thus, gastric adenocarcinoma cells may functionally contribute to the highly immunogenic tumor microenvironment observed in EBVaGCs via a previously unappreciated role in interferon-induced antigen presentation.
Destabilizing single chain major histocompatibility complex class I protein for repurposed enterokinase proteolysis
Authors: Lim Jackwee 
Published: September 2020

AbstractThe lack of a high throughput assay for screening stabilizing peptides prior to building a library of peptide-major histocompatibility complex class I (pMHC-I) molecules has motivated the continual use of in silico tools without biophysical characterization. Here, based on de novo protein fragmentation, the EASY MHC-I (EZ MHC-I) assay favors peptide antigen screening to an unheralded hands-on time of seconds per peptide due to the empty single chain MHC-I protein instability. Unlike tedious traditional labeling- and antibody-based MHC-I assays, repurposed enterokinase directly fragments the unstable single MHC-I chain protein unless rescued by a stabilizing peptide under luminal condition. Herein, the principle behind EZ MHC-I assay not only characterizes the overlooked stability as a known better indicator of immunogenicity than classical affinity but also the novel use of enterokinase from the duodenum to target destabilized MHC-I protein not bearing the standard Asp-Asp-Asp-Asp-Lys motif, which may protend to other protein instability-based assays.
APRIL-producing eosinophils are involved in gastric MALT lymphomagenesis induced by Helicobacter sp infection
Authors: Blosse Alice , Peru Sara , Levy Michael , Marteyn Benoit , Floch Pauline , Sifré Elodie , Giese Alban , Prochazkova-Carlotti Martine , Azzi Martin Lamia , Dubus Pierre , Mégraud Francis , Ruskone Fournestraux Agnès , Fabiani Bettina , Copie Bergman Christiane , Robe Cyrielle , Hahne Michael , Huard Bertrand , Lehours Philippe 
Published: September 2020

AbstractThe roles of the inflammatory response and production of a proliferation-inducing ligand (APRIL) cytokine in gastric mucosa-associated lymphoid tissue (MALT) lymphomagenesis induced by Helicobacter species infection are not clearly understood. We characterized the gastric mucosal inflammatory response associated with gastric MALT lymphoma (GML) and identified APRIL-producing cells in two model systems: an APRIL transgenic mouse model of GML induced by Helicobacter infection (Tg-hAPRIL) and human gastric biopsy samples from Helicobacter pylori-infected GML patients. In the mouse model, polarization of T helper 1 (tbet), T helper 2 (gata3), and regulatory T cell (foxp3) responses was evaluated by quantitative PCR. In humans, a significant increase in april gene expression was observed in GML compared to gastritis. APRIL-producing cells were eosinophilic polynuclear cells located within lymphoid infiltrates, and tumoral B lymphocytes were targeted by APRIL. Together, the results of this study demonstrate that the Treg-balanced inflammatory environment is important for gastric lymphomagenesis induced by Helicobacter species, and suggest the pro-tumorigenic potential of APRIL-producing eosinophils.