bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune biological rationales for the design of combined radio- and immunotherapies
Authors: Hader Michael , Frey Benjamin , Fietkau Rainer , Hecht Markus , Gaipl Udo S. 
Published: January 2020

AbstractCancer immunotherapies are promising treatments for many forms of cancer. Nevertheless, the response rates to, e.g., immune checkpoint inhibitors (ICI), are still in low double-digit percentage. This calls for further therapy optimization that should take into account combination of immunotherapies with classical tumor therapies such as radiotherapy. By designing multimodal approaches, immune modulatory properties of certain radiation schemes, additional immune modulation by immunotherapy with ICI and hyperthermia, as well as patient stratification based on genetic and immune constitutions have to be considered. In this context, both the tumor and its microenvironment including cells of the innate and adaptive immune system have to be viewed in synopsis. Knowledge of immune activation and immune suppression by radiation is the basis for well-elaborated addition of certain immunotherapies. In this review, the focus is set on additional immune stimulation by hyperthermia and restoration of an immune response by ICI. The impact of radiation dose and fractionation on immune modulation in multimodal settings has to be considered, as the dynamics of the immune response and the timing between radiotherapy and immunotherapy. Another big challenge is the patient stratification that should be based on matrices of biomarkers, taking into account genetics, proteomics, radiomics, and “immunomics”. One key aim is to turn immunological “cold” tumors into “hot” tumors, and to eliminate barriers of immune-suppressed or immune-excluded tumors. Comprehensive knowledge of immune alterations induced by radiation and immunotherapy when being applied together should be utilized for patient-adapted treatment planning and testing of innovative tumor therapies within clinical trials.
The semi-automated algorithm for the detection of bone marrow oedema lesions in patients with axial spondyloarthritis
Authors: Kucybała Iwona , Tabor Zbisław , Polak Jakub , Urbanik Andrzej , Wojciechowski Wadim 
Published: January 2020

AbstractThe aim of the study was to create the efficient tool for semi-automated detection of bone marrow oedema lesions in patients with axial spondyloarthritis (axSpA). MRI examinations of 22 sacroiliac joints of patients with confirmed axSpA-related sacroiliitis (median SPARCC score: 14 points) were included into the study. Design of our algorithm is based on Maksymowych et al. evaluation method and consists of the following steps: manual segmentation of bones (T1W sequence), automated detection of reference signal region, sacroiliac joint central lines and ROIs, a division of ROIs into quadrants, automated detection of inflammatory changes (STIR sequence). As a gold standard, two sets of manual lesion delineations were created. Two approaches to the performance assessment of lesion detection were considered: pixel-wise (detections compared pixel by pixel) and quadrant-wise (quadrant to quadrant). Statistical analysis was performed using Spearman's correlation coefficient. Correlation coefficient obtained for pixel-wise comparison of semi-automated and manual detections was 0.87 (p = 0.001), while for quadrant-wise analysis was 0.83 (p = 0.001). The correlation between two sets of manual detections was 0.91 for pixel-wise comparison (p = 0.001) and 0.88 (p = 0.001) for quadrant-wise approach. Spearman’s correlation between two manual assessments was not statistically different from the correlation between semi-automated and manual evaluations, both for pixel- (p = 0.14) and quadrant-wise (p = 0.17) analysis. Average single slice processing time: 0.64 ± 0.30 s. Our method allows for objective detection of bone marrow oedema lesions in patients with axSpA. The quantification of affected pixels and quadrants has comparable reliability to manual assessment.
Partitioning Infinite Hypergraphs into Few Monochromatic Berge-Paths
Authors: Bustamante Sebastián , Corsten Jan , Frankl Nóra 
Published: January 2020

AbstractExtending a result of Rado to hypergraphs, we prove that for all $$s, k, t \in {\mathbb {N}}$$s,k,t∈N with $$k \ge t \ge 2$$k≥t≥2, the vertices of every $$r = s(k-t+1)$$r=s(k-t+1)-edge-coloured countably infinite complete k-graph can be partitioned into the cores of at most s monochromatic t-tight Berge-paths of different colours. We further describe a construction showing that this result is best possible.
The 2018 Kerala floods: a climate change perspective
Authors: Hunt Kieran M. R. , Menon Arathy 
Published: January 2020

AbstractIn August 2018, the Indian state of Kerala received an extended period of very heavy rainfall as a result of a low-pressure system near the beginning of the month being followed several days later by a monsoon depression. The resulting floods killed over 400 people and displaced a million more. Here, a high resolution setup (4 km) of the Weather Research and Forecasting (WRF) model is used in conjunction with a hydrological model (WRF-Hydro, run at 125 m resolution) to explore the circumstances that caused the floods. In addition to a control experiment, two additional experiments are performed by perturbing the boundary conditions to simulate the event in pre-industrial and RCP8.5 background climates. Modelled rainfall closely matched observations over the study period, and it is found that this would this would have been about 18% heavier in the pre-industrial due to recent weakening of monsoon low-pressure systems, but would be 36% heavier in an RCP8.5 climate due to moistening of the tropical troposphere. Modelled river streamflow responds accordingly: it is shown the six major reservoirs that serve the state would have needed to have 34% more capacity to handle the heavy rainfall, and 43% had the deluge been amplified by an RCP8.5 climate. It is further shown that this future climate would have significantly extended the southern boundary of the flooding. Thus it is concluded that while climate change to date may well have mitigated the impacts of the flooding, future climate change would likely exacerbate them.
Consistency of extreme temperature changes in China under a historical half-degree warming increment across different reanalysis and observational datasets
Authors: Zhao Siyao , Zhou Tianjun , Chen Xiaolong 
Published: January 2020

AbstractThe extreme temperature changes under a 0.5 °C global mean surface temperature warming increment is of great importance for climate change adaption and risk management on post-Paris-Agreement agenda. The impacts of the already happened 0.5 °C warming increment on extreme temperature can serve as essential references for the 1.5/2 °C projections. Quantifying the observed changes of climate extremes is hampered by the limitation of observational datasets in both spatial coverage and temporal continuity. The reanalysis datasets are hoped to be useful substitutes for the observations, but their performance over continental China remains unknown. In this study, we compare the extreme temperature changes associated with the past 0.5 °C warming derived from three reanalysis datasets including JRA-55, ERA and 20CR with the observation in China. Distinct increases (decreases) in warm (cold) extremes are detected in all three reanalyses in a spatially aggregated perspective as in the observation. On regional scales the reanalyses have evident spreads in regions with insufficient observational coverage such as the western China. JRA-55 shows good agreement with the observation in both spatial patterns and magnitudes of extreme temperature changes. Both ERA and 20CR show weaker consistency with the observation, particularly in western China, mainly due to less observational constraints in data assimilation. The different aerosol data used in reanalysis assimilation systems also influenced the data quality. Our results indicate that while the reanalyses can serve as useful substitutes to fill in the observational gaps, cautious should be taken in regions with sparse observations and large anthropogenic aerosol emissions.
Cases of asphyxia in children and adolescents: a retrospective analysis of fatal accidents, suicides, and homicides from 1998 to 2017 in Hamburg, Germany
Authors: Mosek Dieu Phuong , Sperhake Jan Peter , Edler Carolin , Püschel Klaus , Schröder Ann Sophie 
Published: January 2020

Abstract
Purpose
Injury-related asphyxia is one of the most common causes of death in children in Germany. However, only a few systematic studies have analyzed the causes and circumstances of asphyxia in children and adolescents.

Methods
All cases of asphyxia in children and adolescents (0–21 years of age) among the Hamburg Legal Medical Department’s autopsy cases from 1998 to 2017 were retrospectively analyzed with special focus on how often external findings were completely absent.

Results
Among 249 cases of fatal asphyxia, 68% were accidents, 14% were suicides, and 13% were homicides. Most of the cases involved boys. Adolescents and young adults aged 15–21 years represented the main age group. Drowning was the leading mechanism of asphyxia. Younger age was associated with less frequent detection of external signs of asphyxia in the postmortem external examination. Petechial hemorrhages were the most common visible external indication of asphyxia. No external findings indicative of asphyxia were present in 14% of the cases.

Conclusion
Asphyxia in children and adolescents often involves accidents. However, postmortem external examination alone is insufficient to identify asphyxia and the manner of death.
Single mean arterial blood pressure drops during stroke thrombectomy under general anaesthesia are associated with poor outcome
Authors: Fandler-Höfler Simon , Heschl Stefan , Argüelles-Delgado Placido , Kneihsl Markus , Hassler Eva , Magyar Marton , Kainz Andreas , Berghold Andrea , Niederkorn Kurt , Deutschmann Hannes , Fazekas Franz , Gattringer Thomas 
Published: January 2020

Abstract
Background
We examined the influence of periprocedural blood pressure (BP), especially critical BP drops, on 3-month functional outcome in stroke patients undergoing mechanical thrombectomy (MT) under general anaesthesia (GA).

Methods
We screened all patients with anterior circulation large vessel occlusion receiving MT under GA at our centre from January 2011 to June 2016 and selected those who had continuous invasive periinterventional BP monitoring. Clinical and radiological data were prospectively collected as part of an ongoing cohort study, monitoring data were extracted from electronic anaesthesia records. We used uni- and multivariable regression to investigate the association of BP values with unfavourable outcome, defined as modified Rankin Scale scores 3–6 3 months post-stroke.

Results
115 patients were included in this study (mean age 65.3 ± 13.0 years, 55.7% male). Periinterventional systolic, diastolic, and mean arterial BP (MAP) values averaged across MT had no effect on outcome. However, single BP drops were related to unfavourable outcome, with absolute MAP drops showing the highest association compared to both systolic and relative BP drops (with reference to pre-interventional values). The BP value with the strongest association with unfavourable outcome was identified as an MAP ever < 60 mmHg (p = 0.01) with a pronounced effect in patients with poor collaterals. An MAP < 60 mmHg remained independently associated with poor functional outcome in multivariable analysis (p < 0.01).

Conclusions
For patients undergoing MT under GA, single MAP drops < 60 mmHg are independently related to unfavourable 3-month outcome. Therefore, every effort should be made to prevent periinterventional hypotensive episodes, especially below this threshold.
Establishing metrics and control laws for the learning process: ball and beam balancing
Authors: Buza Gergely , Milton John , Bencsik Laszlo , Insperger Tamas 
Published: January 2020

AbstractUnderstanding how dexterity improves with practice is a fundamental challenge of motor control and neurorehabilitation. Here we investigate a ball and beam implementation of a dexterity puzzle in which subjects stabilize a ball at the mid-point of a beam by manipulating the angular position of the beam. Stabilizability analysis of different biomechanical models for the ball and beam task with time-delayed proportional-derivative feedback identified the angular position of the beam as the manipulated variable. Consequently, we monitored the changes in the dynamics with learning by measuring changes in the control parameters. Two types of stable motion are possible: node type (nonoscillatory) and spiral type (oscillatory). Both types of motion are observed experimentally and correspond to well-defined regions in the parameter space of the control gains. With practice the control gains for each subject move close to or on the portion of the boundary which separates the node-type and spiral-type solutions and which is associated with the rightmost characteristic exponent of smallest real part. These observations suggest that with learning the control gains for ball and beam balancing change in such a way that minimizes overshoot and the settling time. This study provides an example of how mathematical analysis together with careful experimental observations can shed light onto the early stages of skill acquisition. Since the difficulty of this task depends on the length of the beam, ball and beam balancing tasks may be useful for the rehabilitation of children with dyspraxia and those recovering from a stroke.
Multimodal mapping and analysis of the cyto- and receptorarchitecture of the human hippocampus
Authors: Palomero-Gallagher Nicola , Kedo Olga , Mohlberg Hartmut , Zilles Karl , Amunts Katrin 
Published: January 2020

AbstractThe human hippocampal formation is relevant for various aspects of memory and learning, and the different hippocampal regions are differentially affected by neuropsychiatric disorders. Therefore, the hippocampal formation has been subject of numerous cytoarchitectonic and other mapping studies, which resulted in divergent parcellation schemes. To understand the principles of hippocampal architecture, it is necessary to integrate different levels of hippocampal organisation, going beyond one modality. We here applied a multimodal mapping approach combining cyto- and multi-receptorarchitectonic analyses, and generated probabilistic maps in stereotaxic space of the identified regions. Cytoarchitecture in combination with the regional and laminar distribution of 15 neurotransmitter receptors visualized by in vitro receptor autoradiography were analysed in seven hemispheres from 6 unfixed shock frozen and serially sectioned brains. Cytoarchitectonic delineations for generation of probabilistic maps were carried out on histological sections from ten fixed, paraffin embedded and serially sectioned brains. Nine cyto- and receptorarchitectonically distinct regions were identified within the hippocampal formation (i.e., fascia dentata, cornu Ammonis (CA) regions 1–4, prosubiculum, subiculum proper, presubiculum and parasubiculum), as well as the hippocampal-amygdaloid transition area and the periallocortical transsubiculum. Subsequently generated probabilistic maps quantify intersubject variability in the size and extent of these cyto- and receptorarchitectonically distinct regions. The regions did not differ in their volume between the hemispheres and gender. Receptor mapping revealed additional subdivisions which could not be detected by cytoarchitectonic analysis alone. They correspond to parcellations previously found in immunohistochemical and connectivity studies. The multimodal approach enabled the definition of regions not consistently reported, e.g., CA4 region or prosubiculum. The ensuing detailed probabilistic maps of the hippocampal formation constitute the basis for future architectonically informed analyses of in vivo neuroimaging studies.
How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence
Authors: Buentzel Judith , Bauer Christoph , Buentzel Jens 
Published: January 2020

Abstract
Purpose
Oral mucositis is a common, painful side effect of cancer treatment—be it locoregional (e.g. irradiation) or systemic (e. g. chemotherapy). Phytotherapy is often used by patients to alleviate symptoms. However, knowledge on which medical plants are recommended by literature about Traditional European Medicine (TEM), their effect(s) on symptoms and their efficacy is severely lacking. Therefore, we developed a novel approach to assess traditional knowledge of herbals used in TEM and searched the online databases for studies reporting effects of these plants.

Methods
At first, online research did not yield a satisfying number of studies (MESH terms: “mucositis” OR “stomatitis” AND “herbal” OR “herbal medicine”). Trials were labelled by the country conducting the study. In parallel, we compiled a list of 78 plants recommended for treating oral mucositis by screening 14 books on TEM. Then, a “hit list” of the plants most often mentioned was composed and used further for a second online investigation using the Latin plant designations as MESH term. Studies of both online searches were pooled for analysis.

Results
There is a gap between traditional knowledge and trials investigating medical plants used by TEM. Overall, herbal remedies alleviate oral mucositis and especially, gingivitis well. There is good evidence for using Matricaria recutita L., Salvia officinalis L., Calendula officinalis L. and Thymus spp. L. for treating oral mucositis.

Conclusion
Clinical trials investigating medical plants known in TEM are rare. However, following our research strategy, we could extrapolate four plants with good evidence for alleviating symptoms of oral mucositis and gingivitis.
Long non-coding RNA MALAT1 facilitates the tumorigenesis, invasion and glycolysis of multiple myeloma via miR-1271-5p/SOX13 axis
Authors: Liu Na , Feng Song , Li Huanhuan , Chen Xiaoguang , Bai Songting , Liu Yufeng 
Published: January 2020

AbstractBackgroundLong non-coding RNAs (lncRNAs) play crucial roles in the regulation and treatment of multiple myeloma (MM). The objective of this research was to study the functional mechanism of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in MM.MethodsMALAT1, microRNA-1271-5p (miR-1271-5p), and SRY-Box 13 (SOX13) levels were examined by quantitative real-time polymerase chain reaction (qRT-PCR). Cell viability, apoptosis, and invasion were respectively assayed using 3-(4, 5-dimethylthiazol-2-y1)-2, 5-diphenyl tetrazolium bromide (MTT), flow cytometry, and transwell assay. Glycolysis was evaluated by glucose consumption, lactate production, ATP/ADP ratio, and the detection of related enzymes. Associated proteins were measured using Western blot. Target relation was verified via dual-luciferase reporter assay. Xenograft tumor assay was implemented to study the influence of MALAT1 on MM in vivo.ResultsThe up-regulation of MALAT1 and the down-regulation of miR-1271-5p were found in MM serums and cells. MALAT1 knockdown suppressed cell viability, invasion, and glycolysis while expedited cell apoptosis in MM cells. MALAT1 directly targeted miR-1271-5p and miR-1271-5p depression reverted the effects of MALAT1 knockdown on MM cells. SOX13 was a target of miR-1271-5p and SOX13 overexpression weakened the effects of miR-1271-5p on MM. MALAT1 indirectly modulated SOX13 expression through targeting miR-1271-5p. MALAT1 down-regulation inhibited MM growth by miR-1271-5p/SOX13 axis in vivo.ConclusionLncRNA MALAT1 expedited MM tumorigenesis, invasion, and glycolysis via miR-1271-5p/SOX13 axis. MALAT1 might contribute to the therapy of MM as a promising indicator.
Let us talk about death: gender effects in cancer patients’ preferences for end-of-life discussions
Authors: Seifart C. , Riera Knorrenschild J. , Hofmann M. , Nestoriuc Y. , Rief W. , von Blanckenburg P. 
Published: January 2020

Abstract
Purpose
Patients with advanced cancer often receive suboptimal end-of-life (EOL) care. Particularly males with advanced cancer are more likely to receive EOL care that is more aggressive, even if death is imminent. Critical factors determining EOL care are EOL conversations or advance care planning. However, information about gender-related factors influencing EOL conversations is lacking. Therefore, the current study investigates gender differences concerning the content, the desired time point, and the mode of initiation of EOL conversations in cancer patients.

Methods
In a cross-sectional study, 186 female and male cancer patients were asked about their preferences for EOL discussions using a semi-structured interview, focusing on (a) the importance of six different topics (medical and nursing care, organizational, emotional, social, and spiritual/religious aspects), (b) the desired time point, and (c) the mode of discussion initiation.

Results
The importance of EOL topics differs significantly regarding issue (p = 0.002, η2 = 0.02) and gender (p < 0.001, η2 = 0.11). Males wish to avoid the engagement in discussions about death and dying particularly if they are anxious about their end-of-life period. They wish to be addressed regarding the “hard facts” nursing and medical care only. In contrast, females prefer to speak more about “soft facts” and to be addressed about each EOL topic. Independent of gender, the majority of patients prefer to talk rather late: when the disease is getting worse (58%), at the end of their therapy, or when loosing self-sufficiency (27.5%).

Conclusion
The tendency of patients to talk late about EOL issues increases the risk of delayed or missed EOL conversations, which may be due to a knowledge gap regarding the possibility of disease-associated incapability. Furthermore, there are significant gender differences influencing the access to EOL conversations. Therefore, for daily clinical routine, we suggest an early two-step, gender-sensitive approach to end-of-life conversations.
Solenoidal difference quotients and their application to the regularity theory of the p-Stokes system
Authors: Křepela Martin , Růžička Michael 
Published: January 2020

AbstractWe prove existence of a solution to the divergence equation satisfying a new Bogovski-type estimate for the difference quotients. This enables us to give an alternative proof of the interior regularity of the solution to the p-Stokes problem, completely avoiding the pressure. Moreover, as a key preliminary result we prove boundedness of Calderón–Zygmund operators with standard kernels in weighted Lebesgue and Orlicz spaces over a general domain.