bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and genotype distribution of genital human papillomavirus infection in female sex workers in the world: a systematic review and meta-analysis
Authors: Farahmand Mohammad , Moghoofei Mohsen , Dorost Abolfazl , Abbasi Saeedeh , Monavari Seyed Hamidreza , Kiani Seyed Jalal , Tavakoli Ahmad 
Published: September 2020

AbstractBackgroundFemale sex workers (FSWs) are amongst the most susceptible groups to acquire human papillomavirus (HPV) infection and consequently, to develop cervical intraepithelial neoplasia and cervical cancer. This is the first systematic review and meta-analysis to provide estimates of the pooled prevalence of HPV infection and the distribution of HPV types among FSWs across the world.MethodsFive computerized databases were searched for relevant studies published since the inception date of databases to September 2019. The pooled HPV prevalence was calculated by the random effect model described by DerSimonian-Laird. Subgroup analysis was performed to identify the probable sources of heterogeneity. The meta-analysis was performed using the “Metaprop” function in the R package Meta.ResultsSixty-two studies involving 21,402 FSWs from 33 countries were included in this meta-analysis, and the pooled HPV prevalence was 42.6% (95% confidence interval (CI): 38.5–46.7%). HPV-16 (10.1, 95% CI: 8.2–12.5%), HPV-52 (7.9, 95% CI: 5.9–10.7%), and HPV-53 (6.0, 95% CI: 4.4–8.1%) were the most common high-risk HPV types identified among FSWs. The pooled estimated prevalence of HPV infection among FSWs before and after 2010 were slightly different, 43.6% (95% CI: 36.1–51.4%) and 41.9% (95% CI: 37.2–46.8%), respectively.ConclusionDue to the high prevalence of HPV infection, particularly with high-risk types, FSWs have a great susceptibility to the development of cervical and vaginal cancers. Furthermore, they can transmit their infection to their clients, which may result in a high prevalence of HPV and the incidence of HPV-associated malignancies among the general population.
Healthcare managers’ experiences of technostress and the actions they take to handle it – a critical incident analysis
Authors: Stadin Magdalena , Nordin Maria , Fransson Eleonor I. , Broström Anders 
Published: September 2020

Abstract
Background
Healthcare managers, in comparison with other healthcare professionals, have an increased likelihood of experiencing technostress at work. Since knowledge about the causes and severity of technostress and about the strategies healthcare managers use to handle it is limited, the aim of this study was to describe their experience of technostress and the actions they employ to address it.

Methods
An explorative design based on the critical incident technique was used. In total, 20 healthcare managers (10 women, 10 men) from four hospitals in two county councils in Sweden were purposively selected according to professional background, hierarchical management position, control span, time in the management position, and sex. Semi-structured interviews with regard to critical incidents and actions taken to handle technostress were conducted.

Results
Healthcare managers’ experiences of technostress (n = 279) were categorised related to three main areas. These involved ‘negative aspects of digital communication’ (e.g. high workload, invasion of private life, and negative feelings related to digital communication), ‘poor user experience of ICT systems (such as illogicality of the ICT system, time-consuming ICT system, or malfunctioning ICT system) and ‘needs to improve organisational resources’ (e.g. needs associated with digital literacy, user influence and distribution of work and ICT systems). Actions taken to handle technostress (n=196) were described relating to three main areas involving ‘culture, norms and social support’ (such as good email culture, and co-worker support), ‘individual resources’ (e.g. individual strategies and competence) and ‘organisational resources’ (such as IT-related assistance and support).

Conclusions
Healthcare managers described negative aspects of digital communication, poor user experience of ICT systems, and lack of organisational resources as potential technostress creators. These problems were handled by taking action related to culture, norms and social support, and individual as well as organisational resources. All these features, along with consideration of healthcare managers’ job demands and resources in general, should be incorporated into actions monitored by healthcare organisations to improve or maintain a sustainable digitalised environment for healthcare managers.

Trial registration
Regional Ethics Board in Linköping #2017/597–31. Registered 20 March 2018. URL not available.
Sortilin levels correlate with major cardiovascular events of diabetic patients with peripheral artery disease following revascularization: a prospective study
Authors: Biscetti Federico , Nardella Elisabetta , Rando Maria Margherita , Cecchini Andrea Leonardo , Bonadia Nicola , Bruno Piergiorgio , Angelini Flavia , Di Stasi Carmine , Contegiacomo Andrea , Santoliquido Angelo , Pitocco Dario , Landolfi Raffaele , Flex Andrea 
Published: September 2020

Abstract
Background
Peripheral artery disease (PAD) represents one of the most relevant vascular complications of type 2 diabetes mellitus (T2DM). Moreover, T2DM patients suffering from PAD have an increased risk of major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Sortilin, a protein involved in apolipoproteins trafficking, is associated with lower limb PAD in T2DM patients.

Objective
To evaluate the relationship between baseline serum levels of sortilin, MACE and MALE occurrence after revascularization of T2DM patients with PAD and chronic limb-threatening ischemia (CLTI).

Research design and methods
We performed a prospective non-randomized study including 230 statin-free T2DM patients with PAD and CLTI. Sortilin levels were measured before the endovascular intervention and incident outcomes were assessed during a 12 month follow-up.

Results
Sortilin levels were significantly increased in individuals with more aggressive PAD (2.25 ± 0.51 ng/mL vs 1.44 ± 0.47 ng/mL, p < 0.001). During follow-up, 83 MACE and 116 MALE occurred. In patients, who then developed MACE and MALE, sortilin was higher. In particular, 2.46 ± 0.53 ng/mL vs 1.55 ± 0.42 ng/mL, p < 0.001 for MACE and 2.10 ± 0.54 ng/mL vs 1.65 ± 0.65 ng/mL, p < 0.001 for MALE. After adjusting for traditional atherosclerosis risk factors, the association between sortilin and vascular outcomes remained significant in a multivariate analysis. In our receiver operating characteristics (ROC) curve analysis using sortilin levels the prediction of MACE incidence improved (area under the curve [AUC] = 0.94) and MALE (AUC = 0.72).

Conclusions
This study demonstrates that sortilin correlates with incidence of MACE and MALE after endovascular revascularization in a diabetic population with PAD and CLTI.
Does healthcare inequity reflect variations in peoples’ abilities to access healthcare? Results from a multi-jurisdictional interventional study in two high-income countries
Authors: Haggerty Jeannie , Levesque Jean-Frederic , Harris Mark , Scott Catherine , Dahrouge Simone , Lewis Virginia , Dionne Emilie , Stocks Nigel , Russell Grant 
Published: September 2020

Abstract
Background
Primary healthcare services must respond to the healthcare-seeking needs of persons with a wide range of personal and social characteristics. In this study, examined whether socially vulnerable persons exhibit lower abilities to access healthcare. First, we examined how personal and social characteristics are associated with the abilities to access healthcare described in the patient-centered accessibility framework and with the likelihood of reporting problematic access. We then examined whether higher abilities to access healthcare are protective against problematic access. Finally, we explored whether social vulnerabilities predict problematic access after accounting for abilities to access healthcare.

Methods
This is an exploratory analysis of pooled data collected in the Innovative Models Promoting Access-To-Care Transformation (IMPACT) study, a Canadian-Australian research program that aimed to improve access to primary healthcare for vulnerable populations. This specific analysis is based on 284 participants in four study regions who completed a baseline access survey. Hierarchical linear regression models were used to explore the effects of personal or social characteristics on the abilities to access care; logistic regression models, to determine the increased or decreased likelihood of problematic access.

Results
The likelihood of problematic access varies by personal and social characteristics. Those reporting at least two social vulnerabilities are more likely to experience all indicators of problematic access except hospitalizations. Perceived financial status and accumulated vulnerabilities were also associated with lower abilities to access care. Higher scores on abilities to access healthcare are protective against most indicators of problematic access except hospitalizations. Logistic regression models showed that ability to access is more predictive of problematic access than social vulnerability.

Conclusions
We showed that those at higher risk of social vulnerability are more likely to report problematic access and also have low scores on ability to seek, reach, pay, and engage with healthcare. Equity-oriented healthcare interventions should pay particular attention to enhancing people’s abilities to access care in addition to modifying organizational processes and structures that reinforce social systems of discrimination or exclusion.
Evaluating the impact of a small number of areas on spatial estimation
Authors: Aswi Aswi , Cramb Susanna , Duncan Earl , Mengersen Kerrie 
Published: September 2020

AbstractBackgroundThere is an expanding literature on different representations of spatial random effects for different types of spatial correlation structure within the conditional autoregressive class of priors for Bayesian spatial models. However, little is known about the impact of these different priors when the number of areas is small. This paper aimed to investigate this problem both in the context of a case study of spatial analysis of dengue fever and more generally through a simulation study.MethodsBoth the simulation study and the case study considered count data aggregated to a small area level in a region. Five different conditional autoregressive priors for a simple Bayesian Poisson model were considered: independent, Besag-York-Mollié, Leroux, and two variants of a localised clustering model. Data were simulated with eight different sizes of areal grids, ranging from 4 to 2500 areas, and two different levels of both spatial autocorrelation and disease counts. Model goodness-of-fit measures and model estimates were compared. A case study involving dengue fever cases in 14 local areas in Makassar, Indonesia, was also considered.ResultsThe simulation study showed that model performance varied under different scenarios. When areas had low autocorrelation and high counts, and the number of areas was at most 25, the BYM, Leroux and localised$$G = 2$$G=2models performed similarly and better than the independent and localised$$G = 3$$G=3models. However, when the number of areas were at least 100, all models performed differently, and the Leroux model performed the best. Overall, the Leroux model performed the best for every scenario especially when there were at least 16 areas. Based on the case study, the comparative performance of spatial models may also vary for a small number of areas, especially when the data have a relatively large mean and variance over areas. In this case, the localised model withG = 3 was a better choice.ConclusionDetecting spatial patterns can be difficult when there are very few areas. Understanding the characteristics of the data and the relative influence of alternative conditional autoregressive priors is essential in selecting an appropriate Bayesian spatial model.
Mitochondrial donation in translational medicine; from imagination to reality
Authors: Bagheri Hesam Saghaei , Bani Farhad , Tasoglu Savas , Zarebkohan Amir , Rahbarghazi Reza , Sokullu Emel 
Published: September 2020

AbstractThe existence of active crosstalk between cells in a paracrine and juxtacrine manner dictates specific activity under physiological and pathological conditions. Upon juxtacrine interaction between the cells, various types of signaling molecules and organelles are regularly transmitted in response to changes in the microenvironment. To date, it has been well-established that numerous parallel cellular mechanisms participate in the mitochondrial transfer to modulate metabolic needs in the target cells. Since the conception of stem cells activity in the restoration of tissues’ function, it has been elucidated that these cells possess a unique capacity to deliver the mitochondrial package to the juxtaposed cells. The existence of mitochondrial donation potentiates the capacity of modulation in the distinct cells to achieve better therapeutic effects. This review article aims to scrutinize the current knowledge regarding the stem cell’s mitochondrial transfer capacity and their regenerative potential.
Implications for post critical illness trial design: sub-phenotyping trajectories of functional recovery among sepsis survivors
Authors: Puthucheary Zudin A. , Gensichen Jochen S. , Cakiroglu Aylin S. , Cashmore Richard , Edbrooke Lara , Heintze Christoph , Neumann Konrad , Wollersheim Tobias , Denehy Linda , Schmidt Konrad F. R. 
Published: September 2020

Abstract
Background
Patients who survive critical illness suffer from a significant physical disability. The impact of rehabilitation strategies on health-related quality of life is inconsistent, with population heterogeneity cited as one potential confounder. This secondary analysis aimed to (1) examine trajectories of functional recovery in critically ill patients to delineate sub-phenotypes and (2) to assess differences between these cohorts in both clinical characteristics and clinimetric properties of physical function assessment tools.

Methods
Two hundred ninety-one adult sepsis survivors were followed-up for 24 months by telephone interviews. Physical function was assessed using the Physical Component Score (PCS) of the Short Form-36 Questionnaire (SF-36) and Activities of Daily Living and the Extra Short Musculoskeletal Function Assessment (XSFMA-F/B). Longitudinal trajectories were clustered by factor analysis. Logistical regression analyses were applied to patient characteristics potentially determining cluster allocation. Responsiveness, floor and ceiling effects and concurrent validity were assessed within clusters.

Results
One hundred fifty-nine patients completed 24 months of follow-up, presenting overall low PCS scores. Two distinct sub-cohorts were identified, exhibiting complete recovery or persistent impairment. A third sub-cohort could not be classified into either trajectory. Age, education level and number of co-morbidities were independent determinants of poor recovery (AUROC 0.743 ((95%CI 0.659–0.826), p < 0.001). Those with complete recovery trajectories demonstrated high levels of ceiling effects in physical function (PF) (15%), role physical (RP) (45%) and body pain (BP) (57%) domains of the SF-36. Those with persistent impairment demonstrated high levels of floor effects in the same domains: PF (21%), RP (71%) and BP (12%). The PF domain demonstrated high responsiveness between ICU discharge and at 6 months and was predictive of a persistent impairment trajectory (AUROC 0.859 (95%CI 0.804–0.914), p < 0.001).

Conclusions
Within sepsis survivors, two distinct recovery trajectories of physical recovery were demonstrated. Older patients with more co-morbidities and lower educational achievements were more likely to have a persistent physical impairment trajectory.
In regard to trajectory prediction, the PF score of the SF-36 was more responsive than the PCS and could be considered for primary outcomes. Future trials should consider adaptive trial designs that can deal with non-responders or sub-cohort specific outcome measures more effectively.
Do we still need breast cancer screening in the era of targeted therapies and precision medicine?
Authors: Trimboli Rubina Manuela , Giorgi Rossi Paolo , Battisti Nicolò Matteo Luca , Cozzi Andrea , Magni Veronica , Zanardo Moreno , Sardanelli Francesco 
Published: September 2020

AbstractBreast cancer (BC) is the most common female cancer and the second cause of death among women worldwide. The 5-year relative survival rate recently improved up to 90% due to increased population coverage and women’s attendance to organised mammography screening as well as to advances in therapies, especially systemic treatments. Screening attendance is associated with a mortality reduction of at least 30% and a 40% lower risk of advanced disease. The stage at diagnosis remains the strongest predictor of recurrences. Systemic treatments evolved dramatically over the last 20 years: aromatase inhibitors improved the treatment of early-stage luminal BC; targeted monoclonal antibodies changed the natural history of anti-human epidermal growth factor receptor 2-positive (HER2) disease; immunotherapy is currently investigated in patients with triple-negative BC; gene expression profiling is now used with the aim of personalising systemic treatments. In the era of precision medicine, it is a challenging task to define the relative contribution of early diagnosis by screening mammography and systemic treatments in determining BC survival. Estimated contributions before 2000 were 46% for screening and 54% for treatment advances and after 2000, 37% and 63%, respectively. A model showed that the 10-year recurrence rate would be 30% and 25% using respectively chemotherapy or novel treatments in the absence of screening, but would drop to 19% and 15% respectively if associated with mammography screening. Early detection per se has not a curative intent and systemic treatment has limited benefit on advanced stages. Both screening mammography and systemic therapies continue to positively contribute to BC prognosis.
Video-based interviewing in medicine: protocol for a scoping review
Authors: Selvam Rajajee , Hu Richard , Musselman Reilly , Raiche Isabelle , Moloo Husein 
Published: September 2020

Abstract
Background
Careers in healthcare involve an extensive interview process as transitions are made from one level of training to the next. For physicians, interviews mark the gateway from entrance into medical school, acceptance into residency, fellowships, and subsequent job opportunities. Previous literature outlining the costs associated with face-to-face interviews and concerns regarding the climate crisis has triggered an interest in video-based interviews. Barriers to transitioning away from in-person interviews include concerns regarding lack of rapport between applicants and interviewers, and applicants being less able to represent themselves. In a new era ushered in by COVID where many of us have utilized virtual meetings more than any prior time both personally and for work, we wanted to consolidate the current literature on the use of video-based interviews in healthcare and summarize the findings.

Methods
A scoping review will be conducted to explore the benefits and limitations of video-based interviews for both applicants and interviewers within healthcare fields, as well as the perceived barriers associated with transitioning away from face-to-face interviews. The scoping review methodology outlined by Arksey and O’Malley will be implemented. The search strategy developed by the authors in collaboration with an academic health sciences librarian will be conducted across four electronic databases (Embase, MEDLINE, Cochrane Central, and PsycInfo) and supplemented by a review of the grey literature and reference lists of included studies. The study selection process will be documented using the PRISMA flow diagram, and reasons for exclusion following full-text review will be recorded. The extracted data will be analyzed using quantitative and qualitative analysis.

Discussion
Despite previous literature on the costs associated with face-to-face interviews, there has been hesitancy with transitioning to video-based interviews due to concerns of lack of rapport between applicants and interviewers, and applicants being less able to represent themselves. While these limitations have been explored in previous studies, a succinct review of the current literature to guide the effective restructuring of the interview process is lacking. With our scoping review, we hope to fill this gap in the literature to better understand barriers to transitioning from face-to-face interviews and directions for future research.
Preventing the transmission of COVID-19 and other coronaviruses in older adults aged 60 years and above living in long-term care: a rapid review
Authors: Rios Patricia , Radhakrishnan Amruta , Williams Chantal , Ramkissoon Naveeta , Pham Ba’ , Cormack Gordon V. , Grossman Maura R. , Muller Matthew P. , Straus Sharon E. , Tricco Andrea C. 
Published: September 2020

Abstract
Background
The objective of this review was to examine the current guidelines for infection prevention and control (IPAC) of coronavirus disease-19 (COVID-19) or other coronaviruses in adults 60 years or older living in long-term care facilities (LTCF).

Methods
EMBASE, MEDLINE, Cochrane library, pre-print servers, clinical trial registries, and relevant grey literature sources were searched until July 31, 2020, using database searching and an automated method called Continuous Active Learning® (CAL®). All search results were processed using CAL® to identify the most likely relevant citations that were then screened by a single human reviewer. Full-text screening, data abstraction, and quality appraisal were completed by a single reviewer and verified by a second.

Results
Nine clinical practice guidelines (CPGs) were included. The most common recommendation in the CPGs was establishing surveillance and monitoring systems followed by mandating the use of PPE; physically distancing or cohorting residents; environmental cleaning and disinfection; promoting hand and respiratory hygiene among residents, staff, and visitors; and providing sick leave compensation for staff.

Conclusions
Current evidence suggests robust surveillance and monitoring along with support for IPAC initiatives are key to preventing the spread of COVID-19 in LTCF. However, there are significant gaps in the current recommendations especially with regard to the movement of staff between LTCF and their role as possible transmission vectors.

Systematic review registration
PROSPERO CRD42020181993
On the fractional partial integro-differential equations of mixed type with non-instantaneous impulses
Authors: Zhu Bo , Han Baoyan , Liu Lishan , Yu Wenguang 
Published: September 2020

AbstractIn this paper, we consider the initial boundary value problem for a class of nonlinear fractional partial integro-differential equations of mixed type with non-instantaneous impulses in Banach spaces. Sufficient conditions of existence and uniqueness of PC-mild solutions for the equations are obtained via general Banach contraction mapping principle, Krasnoselskii’s fixed point theorem, andα-order solution operator.