bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural history and impact of treatment with tafamidis on major cardiovascular outcome‐free survival time in a cohort of patients with transthyretin amyloidosis
Authors: Bézard Mélanie , Kharoubi Mounira , Galat Arnault , Poullot Elsa , Guendouz Soulef , Fanen Pascale , Funalot Benoit , Moktefi Anissa , Lefaucheur Jean‐Pascal , Abulizi Mukedaisi , Deux Jean‐François , Gendre Thierry , Audard Vincent , el Karoui Khalil , Canoui‐Poitrine Florence , Zaroui Amira , Itti Emmanuel , Teiger Emmanuel , Planté‐Bordeneuve Violaine , Oghina Silvia , Damy Thibaud 
Published: October 2020

AbstractAimsHereditary (ATTRv) and wild‐type (ATTRwt) transthyretin amyloidosis are severe and fatal systemic diseases, characterised by amyloid fibrillar accumulation principally in the heart or peripheral nerves (or both). Since 2012, tafamidis has been used in France to treat patients with ATTRv with neuropathy (alone or combined with cardiomyopathy). Recently, the Phase III ATTR‐ACT trial showed that tafamidis decreased the relative risk of mortality in ATTR amyloidosis with cardiomyopathy. The aims of this study were to assess the clinical characteristics of ATTR amyloidosis in a real‐life population in comparison to the population included in the ATTR‐ACT trial and to assess the impact of tafamidis treatment on major cardiovascular outcome (MCO)‐free survival time without cardiac decompensation, heart transplant, or death.Methods and resultsFrom June 2008 to November 2018, 648 patients with ATTR amyloidosis (423 ATTRwt and 225 ATTRv) consecutively referred to the French Referral Center for cardiac amyloidosis were included. A total of 467 (72%) patients matched the inclusion criteria of the ATTR‐ACT trial. For the 631 patients with cardiomyopathy, tafamidis treatment wasassociated with a longer median MCO‐free survival time (n = 98): 1565 (1010–2400) days vs. 771 (686–895) days without treatment (log‐rank P < 0.001). This association was confirmed after considering confounding factors (age at inclusion, N‐terminal pro‐B‐type natriuretic peptide and amyloidosis type) with a propensity score (hazard ratio 0.546; P = 0.0132).ConclusionIn a large cohort of ATTRwt and ATTRv patients, representative of the inclusion criteria of the ATTR‐ACT trial, the present results show an association between tafamidis treatment and a lower occurrence of cardiovascular outcomes in a real‐life population.
Recent progress of triboelectric nanogenerators: From fundamental theory to practical applications
Authors: Luo Jianjun , Wang Zhong Lin 
Published: October 2020

AbstractFor the development of the internet of things (IoTs), big data, and artificial intelligence, widely distributed sensing network is the most essential element, which has to be driven by the energy storage unit, with a limited lifetime and environmental concerns. Given that the wide distribution and high mobility of these numerous sensors, the success of the IoTs and sustainable development of human society call for renewable distributed energy sources. Since triboelectrification effect is ubiquitous and universal in our living environment, the triboelectric nanogenerator (TENG) for mechanical energy harvesting and self‐powered sensing developed by Wang and co‐workers is one of the best choices for this energy for the new era. In this review, the recent progress of TENGs from fundamental theory to practical applications is systematically summarized. First, the mechanism of contact electrification, first principle theory, working principle, working modes, and figure of merits of the TENG are introduced. Furthermore, recent important progress in four major TENG applications, including micro/nano power sources, active self‐powered sensors, large‐scale blue energy, and direct high‐voltage power sources are reviewed. In the end, some perspectives and challenges for the future development of TENG are also discussed.image
Four new species in subsection Asterotricha for the genus Onosma L. (Boraginaceae) from flora of Iran
Authors: Attar Farideh , Sotoodeh Arash , Mirtadzadini Mansour 
Published: October 2020

Onosma khorramabadensis, O. lorestanica, O. sahandica and O. kerendica are described and photographed as new species from Lorestan, Eest Azarbayejan and Kermanshah provinces of Iran. Based on Flora Iranica, all the new species can be placed in the sect. Onosma subsect. Asterotricha considering their stellate‐hairy tubercles on leaves.The first new species has some similarities to Onosma bilabiata and O. elwendica based on having accrescent and two connected calyx lobes, but can be distinguished by its stem leaves shape and size, elongate inflorescence and more characters. O. lorestanica is close to O. elwendica by having spathulate leaves shape and nearly same fruiting calyx length; however it differs by its dense short capitate cyme in flowering time, tubercles density and rays arrangements on the tubercles. O. sahandica can be also close to O. bilabiata and O. elwendica for its fruiting calyx length and corolla color, but differs by having free calyx lobes and not accrescent at fruiting time. O. kerendica is related to O. cardiostegia by its habit and inflorescence shape, but can be distinguished by length of lowest bracts, its inflorescence size in fruiting time, pedicel length and filaments attachment place.The recent introduced species, Onosma zagrica (Dehshiri, 2018) should be classified into subsection Asterotricha instead of being in subsection Onosma according to its description and type specimen examination.Distribution map, micrographs of details of important characteristics and a diagnostic key are presented.
Influence of elasticity in an inclined annulus of nanofluid with peristaltic transport
Authors: Sreenadh Sreedharamalle , Sumalatha Baina , Srinivas Akkiraju Naga Satya 
Published: October 2020

AbstractPeristaltic transport of Newtonian nanofluid in an inclined annulus terms of radii regarding peristalsis and elasticity. It is noticed that with an increase in amplitude ratio, flux is getting enhanced in the absence of nanoparticles when compared with viscous fluid with nanoparticles. Our results reduce to the corresponding ones of Rubinow and Keller as a special case for the viscous flow in an elastic tube. The effect of various emerging parameters bounded by two concentric cylinders is studied under the assumption of long wavelength and dominance of viscous effects over inertial effects. The outer cylinder is elastic in nature and has a sinusoidal wave traveling down in its wall, whereas the inner cylinder is rigid. Analytical solutions have been established for velocity, flux, pressure rise, temperature distribution, and nanoparticle concentration. The flux, pressure rise, and frictional forces have been obtained in on the flow characteristic are presented and discussed. Obtained results may be useful in understanding the behavior of peristaltic transport of blood flow in small blood vessels and blood flow through elastic arteries.
Numerical investigation of natural convection of a non‐Newtonian nanofluid in an F‐shaped porous cavity
Authors: Almensoury Mushtaq F. , Hashim Atheer S. , Hamzah Hameed K. , Ali Farooq H. 
Published: October 2020

AbstractThis study numerically investigates the free convective heat transfer of a non‐Newtonian nanofluid through an F‐shaped porous cavity. The thermal conditions of the walls of the cavity are assigned as TC and TH for the cold right wall and the hot left wall, respectively, and the remaining walls of the cavity are assigned as insulated walls. The model for this investigation is designed, implemented, and analyzed by COMSOL Multiphysics. The Galerkin finite element method is used to model and solve the governing equations of the flow and heat transfer process inside the porous media. Physical parameters are presented in the following order: and . The goal of this study is to study the influence of geometry configuration (F shape) and the above parameters on the flow structure, isotherms, and heat transfer. These parameters have been taken into account to investigate their effects on this kind of heat transfer mechanism. Results show that the addition of nanoparticles plays a significant role in changing heat transfer rates. In addition, an increase in the aspect ratio (AR) leads to create narrow areas, which promotes the stagnation zones, thus decreasing the distance between cold and hot walls. This, in turn, enhances the flow uniformity. Moreover, it has been generally concluded that the Nusselt number and velocity rates are directly proportional to the AR, Darcy number (Da), and Rayleigh number (Ra), and negatively proportional to the power‐law index (); however, there are some exceptions and unusual behaviors noticed and explained through the paper.
Epithelial‐to‐mesenchymal transition in oral squamous cell carcinoma: Challenges and opportunities
Authors: Ling Zihang , Cheng Bin , Tao Xiaoan 
Published: October 2020

AbstractOral squamous cell carcinoma (OSCC) is the most common malignancy representing 90% of all forms of oral cancer worldwide. Although great efforts have been made in the past decades, the 5‐year survival rate of OSCC patients is no more than 60% due to tumor metastasis and subsequent recurrence. The metastasis from the primary site is due to a complex process known as epithelial‐to‐mesenchymal transition (EMT). During the EMT, epithelial cells gradually acquire the structural and functional characteristics of mesenchymal cells, leading to the upregulation of cell migration and the promotion of tumor cell dissemination. Therefore, EMT attracted broad attention due to its close relationship with cancer invasion and metastasis. Therefore, in the present review, an extensive description of the current research on OSCC and the role of EMT in this cancer type is provided, including diverse EMT markers, regulatory networks and crucial EMT‐inducing transcription factors in OSCC. Moreover, a brief summary was made regarding the current application of EMT‐correlated indexes in the prognostic analysis of OSCC patients, and the potential therapeutic approaches against OSCC and difficulties in the development of an effective anti‐EMT treatment are discussed. Our aim is to provide novel insights to develop new strategies to combat OSCC by targeting EMT.
Filgrastim associations with CAR T‐cell therapy
Authors: Gaut Daria , Tang Kevin , Sim Myung Shin , Duong Tuyen , Young Patricia , Sasine Joshua 
Published: October 2020

AbstractLittle is known about the benefits and risks of myeloid growth factor administration after chimeric antigen receptor (CAR) T‐cell therapy for diffuse large B‐cell lymphoma (DLBCL). We present a retrospective analysis among 22 relapsed/refractory DLBCL patients who received CAR T‐cell therapy with axicabtagene ciloleucel. Filgrastim was administered by physician discretion to seven patients (31.8%), and the median duration of neutropenia after lymphodepleting therapy was significantly shorter for those patients who received filgrastim (5 vs 15 days, P = .016). Five patients (22.7%) developed infection in the 30 days post‐CAR T‐cell therapy with three patients being Grade 3 or higher. There was no difference in the incidence and severity of infection based on filgrastim use (P = .274, P = .138). Among the seven patients that received filgrastim, six patients (85.7%) and four patients (57.1%) had evidence of cytokine release syndrome (CRS) and immune effector cell‐associated neurotoxicity syndrome (ICANS), respectively. Among the 15 patients that did not receive filgrastim, 8 patients (53.3%) and 7 patients (46.7%) had evidence of CRS and ICANS, respectively. There was no significant difference in the incidence of developing CRS or ICANS between the group of patients that received filgrastim and those that did not (P = .193, P = .647). However, there was a significant increase in the severity of CRS for patients that received filgrastim compared to those that did not (P = .042). Filgrastim administration after CAR T‐cell therapy may lead to an increase in severity of CRS without decreasing infection rates.
A new approach to exchange rate forecast: The role of global financial cycle and time‐varying parameters
Authors: Raheem Ibrahim D. , Vo Xuan Vinh 
Published: October 2020

AbstractThe exchange rate disconnect puzzle argues that macroeconomic fundamentals are not able to accurately predict exchange rate. Recent studies have shown that the puzzle could be upturned if: (a) the dataset is structured in a panel form; (b) the model is based on the portfolio balance theory (PBT); (c) factor models are employed and (d) time‐varying parameter (TVP) regression is used. This study combines these strands of the literature. Essentially, the study conjectures that Global Financial Cycle (GFCy), drawing inspiration from PBT, has some predictive information content on exchange rate. Using dataset from 25 countries, we produced some mixed results. On the whole, the GFCy is able to produce lower forecast error, as compared to the that of benchmark model. However, its effectiveness is dependent upon the regression type (TVP vs. Panel Fixed Effect); forecast horizons (short vs. long); the sample period (early vs. late) and measures of GFCy. The results are robust to a number of checks.
Triple novelty block detection and classification approach for lung tumor analysis
Authors: Rani K. Vijila , Dayana C. Thinkal , Therese P. Sujatha , Prince M. Eugine 
Published: October 2020

AbstractRecently the increased utilization of computer‐aided detection is more helpful to assist the radiologist, recognize the minute lung lesion. In this research article, we propose three novel block detection methods for lung lesion segmentation. First, an automatic algorithm for lung lesion detection and segmentation by using histogram‐based affine‐invariant detection (HAID) is proposed. HAID is a novel segmentation technique that applies enhanced maximally stable extremal region algorithm results to segment the lung lesion. The lung lesions are segmented with an accuracy of 91.5% and false positives per scan is 5.52. To reduce the false positives per scan of lung tumor segmentation, a spatial constraint‐based new fuzzy clustering (SCNFC) approach is then proposed. The experimental results proved the efficiency of the SCNFC technique in the successful segmentation of lung tumor tissues with high accuracy and reduced the false positive per scan (95.21% and 3.69 for a database of simulated computed tomography images). Finally, firefly search‐based Macqueen's K‐means clustering algorithm (FSMKC) is proposed. The performance of the FSMKC method is evaluated on series assessments using the Lung Image Database Consortium dataset (1505 images) and it achieved the accuracy of 97.18% and 96.28% of sensitivity with only 2.27 false positives per scan.
In vivo osseointegration and erosion of nacre screws in an animal model
Authors: Kün‐Darbois Jean‐Daniel , Libouban Hélène , Camprasse Georges , Camprasse Serge , Chappard Daniel 
Published: October 2020

AbstractThe use of resorbable devices for osteosynthesis has become a subject of interest. Nacre has been proposed as a resorbable and osteoconductive material favoring bone apposition without triggering an inflammatory reaction. We compared the in vivo osseointegration and erosion of nacre screws in an animal model with titanium screws. Implantation of similar nacre and titanium screws was performed in the femoral condyles of adult rats. Animals (n = 41) were randomized in four groups sacrificed at day one, 1, 6, and 12 months. Microcomputed tomography (microCT) allowed 3D morphometry of erosion of nacre. Osseointegration was measured as the volume of trabecular bone bone volume/tissue volume (BV/TV) in a standardized volume of interest around each screw. Undecalcified bone histology was also done. Gross examination revealed a similar clinical osseointegration for titanium and nacre screws. A progressive erosion of nacre screws, but no erosion of titanium screws, was observed in microCT. The volume of nacre screws progressively decreased over time whereas no modification occurred for titanium. For titanium screws, BV/TV remained stable throughout the study. For nacre screws, the BV/TV decrease was not statistically different. A significant difference was found between nacre and titanium screws at 6 months but not at 12 months. The screw heads, outside the bone shaft, were not eroded even after 12 months. Erosion of nacre occurred during the entire study period, only within the bone shaft in direct contact with bone marrow. Bone apposition was observed on nacre surfaces without signs of erosion. Nacre is a promising biomaterial in maxillofacial surgery.
Changes in clients and therapists experiences of therapeutic distance during psychodynamic therapy
Authors: Egozi Sharon , Tishby Orya , Wiseman Hadas 
Published: October 2020

AbstractAttachment theory provides a framework for examining closeness–distance experiences in the development of the therapeutic relationship.ObjectiveTo examine changes in clients' and therapists' experiences of therapeutic distance along with psychodynamic therapy. Hypotheses: Clients' and therapists' comfort with closeness and distance will increase, and the client's autonomy and engagement will increase with time.MethodA total of 67 clients and their 27 therapists underwent Relationship Paradigm interviews in which they told narratives about their experience with each other, three times during therapy. The narratives were rated on the Therapeutic Distance Scale‐Observer (TDS‐O) version.ResultsGrowth curve analysis of the TDS‐O ratings showed that clients decrease in perceiving therapists as too distant and increase in engagement. Therapists showed a decrease in perceiving clients as too close and an increase in granting autonomy and engagement. A clinical illustration depicts these experiences in a client–therapist dyad.ConclusionsTherapists' awareness of clients' changing needs of closeness and autonomy may enhance attunement.
Target identification of a novel unsymmetrical 1,3,4‐oxadiazole derivative with antiproliferative properties
Authors: Weidong Lyu , Sanna Luca , Bordoni Valentina , Tiansheng Zeng , Chengxun Li , Murineddu Gabriele , Pinna Gerard A. , Kelvin David J. , Bagella Luigi 
Published: October 2020

Abstract1,3,4‐Oxadiazole derivatives are widely used in research on antineoplastic drugs. Recently, we discovered a novel unsymmetrical 1,3,4‐oxadiazole compound with antiproliferative properties called 2j. To further investigate its possible targets and molecular mechanisms, RNA‐seq was performed and the differentially expressed genes (DEGs) were obtained after treatment. Data were analyzed using functional (Gene Ontology term) and pathway (Kyoto Encyclopedia of Genes and Genomes) enrichment of the DEGs. The hub genes were determined by the analysis of protein‐protein interaction networks. The connectivity map (CMap) information provided insight into the model action of antitumor small molecule drugs. Hub genes have been identified through function gene networks using STRING analysis. The small molecular targets obtained by CMap comparison showed that 2j is a tubulin inhibitor and it acts mainly affecting tumor cells through the cell cycle, FoxO signaling pathway, apoptotic, and p53 signaling pathways. The possible targets of 2j could be TUBA1A and TUBA4A. Molecular docking results indicated that 2j interacts at the colchicine‐binding site on tubulin.
Impact of oil contamination on ecological functions of peat soils from West Siberia of Russia
Authors: Kovaleva Ekaterina I. , Trofimov Sergey Ya. , Zhongqi Cheng 
Published: October 2020

AbstractFor more than a century, the need for energy has exerted high demand on oil production and led to significant negative impacts on soil and water resources. The aim of our work was to assess such impacts on the ecological functions of oil‐contaminated soils in West Siberia of Russia. The total petroleum hydrocarbons (PHC) content in contaminated soils varied between 3.7 and 390 g kg−1. Although peat had the ability to absorb some PHC, excess oil migrated in soil both downward and laterally. Catalase activity, soil respiration activity (basal respiration [BR], microbial biomass carbon [Cmic], and specific respiration activity [qCO2]), and Enchytraeus albidus survival and reproduction rates showed significant negative correlations with PHC concentrations, and thus they can be used as guides for establishing acceptable PHC limits in peat soils. Based on the Logit model, the concentration of PHC in peat soil that corresponds to ∼20% reduction on functions (worm reproduction, catalase activity, and basal respiration) is about 40–50 g kg−1. The concentrations of PHC that will result in 80% functional reductions (i.e., near‐complete loss on functional activities) are worm production (177 g kg−1), catalase activity (123 g kg−1), and basal respiration (311 g kg−1). This study provides quantitative understanding of the ecological impact of PHC contamination on peat soils and thus helps to establish science‐based guidelines for the protection of ecological functions and services of peatland soils.
Automated Grading of Lumbar Disc Degeneration Using a Push‐Pull Regularization Network Based on MRI
Authors: Gao Fei , Liu Shui , Zhang Xiaodong , Wang Xiaoying , Zhang Jue 
Published: October 2020

BackgroundLower back pain is one of the most widely experienced health problems and is strongly associated with intervertebral disc (IVD) degeneration. The quantification of the degeneration is valuable for estimation of the material properties of the IVDs and then to perform biomechanical simulation of the spinal conditions and treatments. The MR image characteristics of relatively high intraclass variability and small interclass differences pose challenges for the classification algorithm to perform automatic grading of degenerated IVD.PurposeTo assess the feasibility and improvement of a computer‐assisted IVD degeneration grading method based on proposed push‐pull regularization (PPR) strategy.Study TypeRetrospective.PopulationIn total, 500 subjects (350 for training, 70 for validation, and 80 for test in a 10‐time 10‐fold cross validation setting) with varied lumbar disorders were included.Field Strength/Sequence3.0T; T2‐weighted spin echo sequence.AssessmentIVD degeneration grading was taken as a classification task of five classes according to the Pfirrmann grading system in this study. The classification results of deep‐learning models with and without PPR were compared with the classifications made by three experienced spinal radiologists.Statistical TestsPaired t‐tests.ResultsThe classification results show that in four classical CNN models of VGG‐M, VGG‐16, GoogleNet, and ResNet‐34, by embedding a PPR strategy, the accuracies of grade II and III IVD classification were improved by more than 10% (P < 0.05), and that the overall accuracy (grades I to V) was improved by over 8% (P < 0.05).Data ConclusionThe embedded PPR significantly improved the classification performance, which enhanced CNN representation capability for IVD degeneration grading.Level of Evidence3Technical Efficacy Stage1