bluuebunny/crossref_metadata_2025_split huggingface dataset:
PESQUISA BASEADA EM DESIGN E A FORMAÇÃO INICIAL DE PROFESSORES DE MATEMÁTICA: UMA PROPOSTA METODOLOGICA PARA O ENSINO DE GEOMETRIA
Authors: Schons Elisângela Fouchy , Bisognin Eleni 
Published: November 2020

A aprendizagem é uma atividade embasada nas práticas escolares e ocorre a partir da interação entre sujeitos e o meio. Na Matemática, o professor, em geral, é o responsável pela aproximação de seus alunos com o conteúdo, e essa condução é feita a partir dos conhecimentos do conteúdo e didáticos que ele tem. Esse trabalho é um recorte de uma pesquisa de doutorado que, por meio da Pesquisa Baseada em Design, visa ao desenvolvimento de intervenções pedagógicas em contextos reais de sala de aula, com os objetivos de melhorar a prática docente e produzir conhecimento sobre o processo de ensino e aprendizagem de Geometria em alunos estagiários de um curso de Licenciatura em Matemática. Nesse recorte, o Conhecimento do Conteúdo e do Ensino desses estagiários foi analisado a partir do planejamento, aplicação e avaliação de uma atividade realizadacom alunos do Ensino Médio, com o objetivo de conceituar prismas e pirâmides por meio da exploração de embalagens e da utilização de recursos computacionais. Percebeu-se, no desenvolvimento das atividades e no relato dos estagiários, indícios de que eles possuem Conhecimento do Conteúdo e do Ensino, pois programaram recursos, selecionaram metodologias deensino e elaboraram perguntas para tornar o conteúdo mais compreensível aos seus alunos. Pode-se inferir também que, a Pesquisa Baseada em Design por meio de seus pressupostos e organização, mostrou-se eficaz na construção do conhecimento matemático para o ensino desses estagiários na abordagem dos conteúdos de Geometria Espacial com alunos do Ensino Médio.
CENÁRIOS PARA INVESTIGAÇÃO NO ENSINO SUPERIOR: EXPLORANDO O TEOREMA DO VALOR INTERMEDIÁRIO
Authors: Mazzi Lucas Carato , Moura Amanda Queiroz 
Published: November 2020

A Matemática no Ensino Superior tende a ser ensinada de maneira tradicional, na qual o professor é o responsável por transmitir o conhecimento e os estudantes são apenas receptores, semresponsabilidade e sem participação em seu processo de aprendizagem. Visando explorar metodologias que contraponham este modelo de ensino, neste artigo, discutimos possibilidades detarefas investigativas acerca de conceitos matemáticos vistos nas disciplinas de Cálculo Diferencial e Integral e Análise Matemática, em particular o Teorema do Valor Intermediário. Assim, apresentamose analisamos um exemplo de atividade desenvolvida a partir de construções com o software GeoGebra. Para tal, assumimos uma abordagem qualitativa de pesquisa e, como lente teórica, aproposta de Cenários para Investigação, a qual traz como principal característica, a abertura para cooperação investigativa por meio do diálogo. Como resultados, concluímos que, de fato, é possívelenvolver estudantes do Ensino Superior em ambientes de aprendizagem investigativos, e ressaltamos a importância do software para a manutenção do diálogo, o qual dá suporte para a produção do conhecimento matemático.
CONCEITOS DE GEOMETRIA ESPACIAL DE POSIÇÃO: TRATAMENTOS FIGURAIS MOBILIZADOS POR FUTUROS PROFESSORES DE MATEMÁTICA
Authors: Ferner Dienifer da Luz , Soares Maria Arlita da Silveira , Mariani Rita de Cássia Pistóia 
Published: November 2020

Este texto tem por objetivo apresentar a análise de como futuros professores de Matemática realizam tratamentos figurais suscitados durante a resolução de atividades envolvendo conceitos deGeometria Espacial de Posição. Para tal, recorreu-se a teoria dos Registros de Representação Semiótica, em particular, a necessidade de mobilizar e coordenar registros figural e da língua naturalna atividade cognitiva exigida pela Geometria. Foram consideradas transformações cognitivas (tratamento e conversão) e apreensões de uma figura (sequencial, perceptiva, discursiva e operatória).Optou-se por uma abordagem qualitativa, seguindo pressupostos da Análise de Conteúdo. Percebeu-se que as equipes mobilizaram as apreensões perceptiva, discursiva, sequencial, operatória mereológica e de posição. Sublinha-se que umas receberam maior destaque em relação a outras. Além de, frequentemente, não haver articulação entre elas. A apreensão perceptiva sobressaiu-se em relação as demais por ser mobilizada de forma imediata e automática e, por limitações na mobilização das apreensões operatória e discursiva. As modificações figurais (apreensão operatória) foram pouco evidenciadas nas resoluções das atividades. A desconstrução dimensional foi realizada durante todas as atividades propostas, visto a necessidade de reconhecer as unidades figurais para realizar as ações de argumentar, descrever ou até mesmo a de construir o objeto matemático solicitado. É possívelafirmar que o desenvolvimento das atividades contribuiu para uma mudança do modo de ver em Geometria.
COMPRENSIÓN DEL INTERVALO DE CONFIANZA: UN ESTUDIO COMPARADO CON ESTUDIANTES UNIVERSITARIOS Y PREUNIVERSITARIOS
Authors: Hierro Antonio Francisco Roldán López de , Batanero Carmen , Álvarez-Arroyo Rocío 
Published: November 2020

Los intervalos de confianza se enseñan actualmente en España, tanto en los estudios preuniversitarios del Bachillerato de Ciencias Sociales como en la mayoría de grados universitarios, debido a su relevancia en la inferencia estadística. El objetivo de este estudio es el de comparar la comprensión mostrada por distintos tipos de estudiantes de las propiedades esenciales del intervalo de confianza, incluyendo la finalidad de la estimación y el efecto que sobre el intervalo tiene el cambio de la media, que no han sido tenidas en cuenta en la investigación previa. Para ello se analizan las respuestas de 58 estudiantes de Bachillerato, 57 de primer curso de Psicología y 37 de primer curso de Ingeniería a un cuestionario que consta de seis ítems de opción múltiple. Los resultados muestran la existencia de errores ya descritos en la investigación previa, relacionados con la interpretación de la definición del intervalo o de los factores que inciden en su amplitud. Además, se identifican nuevos errores asociados con la relación entre la media muestral y el intervalo, así como con la finalidad de la estimación por intervalos. Se informa de los errores que aparecen tanto con frecuencia similar en lostres grupos como de los que tienen más incidencia en uno de ellos con la finalidad de mejorar la enseñanza del tema.
CD8+ T Cell Co-Expressed Genes Correlate With Clinical Phenotype and Microenvironments of Urothelial Cancer
Authors: Wang Yutao , Yan Kexin , Lin Jiaxing , Liu Yang , Wang Jianfeng , Li Xuejie , Li Xinxin , Hua Zhixiong , Zheng Zhenhua , Shi Jianxiu , Sun Siqing , Bi Jianbin 
Published: November 2020

PurposeTo identify immune-related co-expressed genes that promote CD8+T cell infiltration in bladder cancer, and to explore the interactions among relevant genes in the tumor microenvironment.MethodWe obtained bladder cancer gene matrix and clinical information data from TCGA, GSE32894 and GSE48075. The “estimate” package was used to calculate tumor purity and immune score. The CIBERSORT algorithm was used to assess CD8+T cell proportions. Weighted gene co-expression network analysis was used to identify the co-expression modules with CD8+T cell proportions and bladder tumor purity. Subsequently, we performed correlation analysis among angiogenesis factors, angiogenesis inhibitors, immune inflammatory responses, and CD8+T cell related genes in tumor microenvironment.ResultsA CD8+T cell related co-expression network was identified. Eight co-expressed genes (PSMB8,PSMB9,PSMB10,PSME2,TAP1,IRF1,FBOX6,ETV7) were identified as CD8+T cell-related genes that promoted infiltration of CD8+T cells, and were enriched in the MHC class I tumor antigen presentation process. The proteins level encoded by these genes (PSMB10,PSMB9,PSMB8,TAP1,IRF1, andFBXO6) were lower in the high clinical grade patients, which suggested the clinical phenotype correlation both in mRNA and protein levels. These factors negatively correlated with angiogenesis factors and positively correlated with angiogenesis inhibitors. PD-1 and PD-L1 positively correlated with these genes which suggested PD-1 expression level positively correlated with the biological process composed by these co-expression genes. In the high expression group of these genes, inflammation and immune response were more intense, and the tumor purity was lower, suggesting that these genes were immune protective factors that improved the prognosis in patients with bladder cancer.ConclusionThese co-expressed genes promote high levels of infiltration of CD8+T cells in an immunoproteasome process involved in MHC class I molecules. The mechanism might provide new pathways for treatment of patients who are insensitive to PD-1 immunotherapy due to low degrees of CD8+T cell infiltration.
Synthesis of Recommendations From 25 Countries and 31 Oncology Societies: How to Navigate Through Covid-19 Labyrinth
Authors: Kamposioras Konstantinos , Mauri Davide , Papadimitriou Konstantinos , Anthoney Alan , Hindi Nadia , Petricevic Branka , Dambrosio Mario , Valachis Antonis , Kountourakis Pantelis , Kopecky Jindrich , Kuhar Cvetka Grašič , Popovic Lazar , Chilingirova Nataliya P. , Zarkavelis George , de Mello Ramon Andrade , Plavetić Natalija Dedić , Christopoulos Christos , Mostert Bianca , Goffin John R. , Tzachanis Dimitiros , Saraireh Haytham Hamed , Ma Fei , Pavese Ida , Tolia Maria 
Published: November 2020

IntroductionPandemic COVID-19 is an unexpected challenge for the oncological community, indicating potential detrimental effects on cancer patients. Our aim was to summarize the converging key points providing a general guidance in order to support decision making, pertaining to the oncologic care in the middle of a global outbreak.MethodsWe did an international online search in twenty five countries that have managed a surge in cancer patient numbers. We collected the recommendations from thirty one medical oncology societies.ResultsBy synthesizing guidelines for a) oncology service delivery adjustments, b) general and specific treatment adaptations, and c) discrepancies from guidelines comparison, we present a clinical synopsis with the forty more crucial statements. A Covid-19 risk stratification base was also created in order to obtain a quick, objective patient assessment and a risk-benefit evaluation on a case-by-case basis.ConclusionsIn an attempt to face these complex needs and due to limited understanding of COVID-19, a variability of recommendations based on general epidemiological and infectious disease principles rather than definite cancer-related evidence has evolved. Additionally, the absence of an effective treatment or vaccine requires the development of cancer management guidance, capitalizing on comprehensive COVID-19 oncology experience globally.
Case Report: Chronic Lymphocytic Leukemia With a Rare Translocation t(14;19)(q32;q13) Involving IGH/BCL3 Rearrangements: Report of Three Chinese Cases and Literature Review
Authors: Li Qinlu , Xing Shugang , Zhang Heng , Mao Xia , Xiao Min , Wei Jia , Wang Ying 
Published: November 2020

BackgroundA translocation t(14;19)(q32;q13) leading to a fusion of IGH and BCL3 which is a rare cytogenetic abnormality in CLL patients, has a more aggressive clinical course with a shorter time to first treatment (TTT) and worse overall survival (OS). To date, there is no literature reporting the identification of the t(14;19) in Chinese CLL patients and the reviewing the characteristic of all patients with this abnormality reported previously in the literature.Patients and MethodsWe first demonstrate three cases of t(14;19) translocation among the 200 CLL patients from 2017 to 2019 in our hospital. We investigated several aspects such as clinicopathologic features, cytogenetic analysis, IGHV mutations, next-generation sequencing technology (NGS), and histopathological characteristics in order to clearly define the features of this entity in Chinese patients and compare them with patients reported previously in western countries.ResultsThe clinical and pathological features of our three cases resemble those of earlier reports. All patients had atypical morphologic features and atypical immunophenotypes with low CLL scores detected by flow cytometry. All cases were unmutated in the IGHV mutations. Two cases showed complex karyotype and one case demonstrate missense mutations of TP53 and FBXW7.ConclusionIn conclusion, this is the first report on IGH/BCL3-positive B-CLLs in Chinese people, which provided a comprehensive analysis of clinical and pathological characteristics. In addition to some similar clinical and laboratory features reported in the previous literature, we first found that CLL with t(14;19) has a higher possibility of being accompanied with high complex karyotype (high-CK), which is now regarded as a novel negative prognostic marker. Early identification of this abnormality in CLL patients is so important that patients can benefit from the more aggressive treatments at the onset of the disease.
An Elusive Prize: Transcutaneous Near InfraRed Spectroscopy (NIRS) Monitoring of the Liver
Authors: Guyon Peter W. , Karamlou Tara , Ratnayaka Kanishka , El-Said Howaida G. , Moore John W. , Rao Rohit P. 
Published: November 2020

Introduction: We postulate a relationship between a transcutaneous hepatic NIRS measurement and a directly obtained hepatic vein saturation. If true, hepatic NIRS monitoring (in conjunction with the current dual-site cerebral-renal NIRS paradigm) might increase the sensitivity for detecting shock since regional oxygen delivery changes in the splanchnic circulation before the kidney or brain. We explored a reliable technique for hepatic NIRS monitoring as a prelude to rigorously testing this hypothesis. This proof-of-concept study aimed to validate hepatic NIRS monitoring by comparing hepatic NIRS measurements to direct hepatic vein samples obtained during cardiac catheterization.Method: IRB-approved prospective pilot study of hepatic NIRS monitoring involving 10 patients without liver disease who were already undergoing elective cardiac catheterization. We placed a NIRS monitor on the skin overlying liver during catheterization. Direct measurement of hepatic vein oxygen saturation during the case compared with simultaneous hepatic NIRS measurement.Results: There was no correlation between the Hepatic NIRS values and the directly measured hepatic vein saturation (R = −0.035; P = 0.9238). However, the Hepatic NIRS values correlated with the cardiac output (R = 0.808; P = 0.0047), the systolic arterial blood pressure (R = 0.739; P = 0.0146), and the diastolic arterial blood pressure (R = 0.7548; P = 0.0116).Conclusions: Using the technique described, hepatic NIRS does not correlate well with the hepatic vein saturation. Further optimization of the technique might provide a better measurement. Hepatic NIRS does correlate with cardiac output and thus may still provide a valuable additional piece of hemodynamic information when combined with other non-invasive monitoring.
The Association for Human Pharmacology in the Pharmaceutical Industry London Meeting October 2019: Impending Change, Innovation, and Future Challenges
Authors: Khan Shahzadgai , Albayaty Muna , Bush James , Cheriyan Joseph , Cromie Anthea , Koch Annelize , Hammond Michael , Mair Stuart , Lorch Ulrike , Stringer Steffan , Taubel Jorg , Hardman Timothy C. 
Published: November 2020

The Association for Human Pharmacology in the Pharmaceutical Industry (AHPPI) annual meeting focused on impending change, innovation, and future challenges facing early phase drug development as we move into the second decade of the 21th century. The meeting opened with discussion around the technical revolution in pharmaceutical medicine over the 4 decades since the AHPPI was founded and how transformative technologies have accompanied the introduction of processes such as physiologically based pharmacokinetic modeling. During the meeting examples were presented of how in terms of the development of new therapies, the classic phases of clinical drug development are becoming a thing of the past and the lines between the phases have begun to blur, particularly in the field of oncology. The contribution that monoclonal antibodies have made to medicine and the next chapter in their design and use was also discussed. A representative of the UK’s Medicine and Healthcare Products Regulatory Agency discussed the increasing numbers of requests to approve complex innovative design trials, how novel trial designs are impacting on the traditional linear “phase” approach to drug development and the common pitfalls associated with them. Guidance was provided from a regulator’s viewpoint on what was meant by the term “novel design” and how to submit successful trial applications for such complex trials. In an Oxford-style debate, the audience discussed the motion that “there is no longer a need to include placebo subjects in early clinical trials.” The keynote speaker focused on delivering change in complex environments such as the field of drug development. The afternoon session included presentations on the challenges associated with drug product design, the complexities within non-oral dosage forms and proposed new methods of formulations for drug delivery. Presentations were also given on advances in mechanistic and computational pharmacokinetic modeling and how they have proved to be valuable tools to rationalize and facilitate the process of drug development.
Apelin Inhibits Angiotensin II-Induced Atrial Fibrosis and Atrial Fibrillation via TGF-β1/Smad2/α-SMA Pathway
Authors: Lv Wenkui , Zhang Ling , Cheng Xinchun , Wang Hongli , Qin Wen , Zhou Xianhui , Tang Baopeng 
Published: November 2020

BackgroundAngiotensin II (Ang II) could promote the development of atrial fibrosis in atrial fibrillation (AF). Apelin can inhibit the occurrence of myocardial fibrosis. However, the effect of apelin on Ang II-induced atrial fibrosis and subsequent AF still remains unknown.ObjectiveIn the present study, we examined the effect of apelin on the suppression of atrial fibrosis and subsequent AF, and investigated its underlying mechanisms.MethodsSprague-Dawley rats were treated for 2 weeks with Ang II (1080 μg/kg/24 h) and apelin-13 (140 μg/kg/24 h) using implantable mini-pumps. The incidence of AF induced by atrial pacing was determined. Atrial electrophysiological mapping was recorded by a 32-electrode microelectrode array. Blood was collected to measure the levels of Ang II and apelin. Atrial tissue samples were preserved to assess the pathohistological changes, DDR2 and α-SMA co-staining were performed, and the protein expression of Smad2 phosphorylation was evaluated.ResultsApelin significantly inhibited Ang II-induced atrial fibrosis (HE:1.45 ± 0.11 vs 6.12 ± 0.16, P &lt; 0.001; Masson:1.49 ± 0.25 vs 8.15 ± 0.23, P &lt; 0.001; Picrosirius Red:1.98 ± 0.64 vs 9.59 ± 0.56, P &lt; 0.001, respectively) and decreased the vulnerability of AF (inducibility of AF: z = −4.40, P &lt; 0.001; total AF duration: z = −4.349, P &lt; 0.001). Left atrial epicardial mapping studies demonstrated preservation of atrial conduction homogeneity by apelin. The protective effects of apelin from fibrotic remodeling were mediated by suppression of Smad2-dependent fibrosis.ConclusionApelin potently inhibited Ang II-induced atrial fibrosis and subsequent vulnerability to AF induction via suppression TGF-β/Smad2/α-SMA pathway. Our results indicated that apelin might be an effective up-stream therapy for atrial fibrosis and AF.
Positive and Negative Experiences of Living in COVID-19 Pandemic: Analysis of Italian Adolescents’ Narratives
Authors: Fioretti Chiara , Palladino Benedetta Emanuela , Nocentini Annalaura , Menesini Ersilia 
Published: November 2020

IntroductionDespite a growing interest in the field, scarce narrative studies have delved into adolescents’ psychological experiences related to global emergencies caused by infective diseases. The present study aims to investigate adolescents’ narratives on positive and negative experiences related to COVID-19.MethodsItalian adolescents, 2,758 (females = 74.8%, mean age = 16.64, SD = 1.43), completed two narrative tasks on their most negative and positive experiences during the COVID-19 emergency. Data were analyzed by modeling an analysis of emergent themes.Results“Staying home as a limitation of autonomy,” “School as an educational, not relational environment,” the impact of a “new life routine,” and experiencing “anguish and loss” are the four emergent themes for negative experiences. As for positive experiences, the four themes were “Being part of an extraordinary experience,” “Discovering oneself,” “Re-discovering family,” and “Sharing life at a distance.”ConclusionAuthors discuss the impact of COVID-19 on adolescents’ developmental tasks, such as identity processes and autonomy acquisition.
Argumentação na língua e blocos semânticos: relações de sentido em postagem do Facebook
Authors: De Freitas Ernani , Demetrio da Silva Scariot Viviane 
Published: November 2020

Este artigo apresenta a sistematização e aplicação de alguns conceitos da Teoria da Argumentação da Língua (TAL), no que se refere ao terceiro momento da teoria: os Blocos Semânticos. O corpus do trabalho é uma publicação chamada: “O que faz um professor?” (2018), veiculado na Internet. O objetivo geral visa descrever e analisar a construção de sentidos dos enunciados presentes numa postagem do Facebook, a partir das relações argumentativas estabelecidas. O suporte teórico apresenta as contribuições referentes à Teoria da Argumentação da Língua e a Teoria dos Blocos Semânticos (TBS), desenvolvida por Ducrot (1988, 2002) e Carel (2005). A pesquisa realiza-se de maneira descritiva e bibliográfica, com abordagem qualitativa. O estudo justifica-se pelo fato da teoria considerar o conjunto do enunciado e não sua individualidade possibilitando que o sentido seja construído no próprio discurso e não de forma extralinguística.
Os bacharéis fardados
Authors: Soares Matos Geisimara 
Published: November 2020

O objetivo deste artigo é pensar, por meio da análise de treze trajetórias descritas em fés de ofício de militares, como o discurso do mérito foi praticado dentro da Escola Militar da Praia Vermelha. Com base nisso, procuramos entender como a cor e a origem social dos alunos influenciavam a prática do discurso da meritocracia na instituição. Por fim, tentamos mostrar a ambiguidade no princípio do mérito que, por um lado promovia as capacidades de um aluno pardo e de origem pobre e, por outro, mantinha a proteção através da velha ordem.
“Nuestro trabajo es el alimento del pueblo”: experiencias de organización colectiva de los productores hortícolas del periurbano rosarino (Santa Fe)
Authors: LILLI LICIA MARIA 
Published: November 2020

Este artículo aborda el proceso de construcción política, desplegado por productores hortícolas, agrupados en el Movimiento de Trabajadores Excluidos- (CTEP), analizando los modos en que la organización del colectivo se encarna en experiencias de precariedad. Situamos dicha experiencia en un escenario de gran visibilidad pública y de conflictividad social, de parte del sector de la agricultura familiar, en Argentina para el periodo 2016-2018.
Argumentamos que la necesidad de “sostener la vida”, en el marco de profundas e históricas condiciones de precariedad, posibilitó la construcción colectiva de formas organizativas gremiales que implicaron producción de política y por ello la conformación de sujetos políticos. Desde un enfoque etnográfico y a partir de una metodología participativa, nos proponemos (re) pensar los horizontes de posibilidad para la acción política de los sectores populares, en un contexto de retracción de derechos y bienestares en torno al trabajo y a la vida.