bluuebunny/crossref_metadata_2025_split huggingface dataset:
P175 Prognostic value of 99mTc-ECD brain perfusion SPECT in patients with atrial fibrillation and dementia
Authors: Hashimoto H , Nakanishi R , Mizumura S , Hashimoto Y , Okamura Y , Yamanaka K , Ikeda T 
Published: January 2020

Abstract

Background
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and those afflicted have reduced quality of life, functional status, and cardiac performance. The patients with AF have a high risk of coronary heart disease and cardiovascular disease. Although the prevalence of AF is increasing, cognitive disorders are also on the rise in tandem with the aging of the population. The patients with dementia have also experienced lower the quality of life and have increased mortality. Technetium 99m ECD brain perfusion single photon emission computed tomography (99mTc-ECD brain perfusion SPECT) is a useful modality for diagnosing dementia and identifying high risk patients with mild cognitive impairment. However, there are few reports about the relationship between the value of Z score calculated by 99mTc-ECD brain perfusion SPECT and prognosis of patients with AF and dementia.

Purpose
The aim of this study was to evaluate the prognostic values of brain perfusion using 99mTc-ECD SPECT in patients with AF and dementia.

Methods
Among 405 consecutive patients who were diagnosed as AF in cardiac outpatients and subsequently diagnosed as dementia using Mini-Mental State Examination by neurologists or psychiatrists, we identified 170 patients (81 ± 10 years) who underwent 99mTc-ECD brain perfusion SPECT for the current study. Of those, 73, 73, and 24 were diagnosed as Alzheimer’s dementia (AD), vascular dementia (VD), and non-specified dementia respectively. Multivariate Cox model was used to assess if higher Z score by 99mTc-ECD brain perfusion SPECT and clinical parameters were associated with major adverse cardiovascular events (MACE) including cardiac death, myocardial infarction, hospitalization for heart failure, and stroke. Sub-analyses of multivariate Cox models by AD or VD were also assessed. The cut-off values of Z score were determined using area under the curve by a receiver operating characteristic analysis based on MACE occurrences.

Results
During a mean follow-up of 1258 ± 1044 days, 62 MACE occurred. There was not significant difference of MACE between AD and VD (33%, vs. 44%, p = 0.153). By multivariable Cox model, the higher Z score of temporal-occipital-pariental lobe was associated with increased MACE compared to the lower group (HR 2.521, 95% CI 1.465–4.337, p &lt; 0.001). In a sub-analysis of patients with AD, Z score was the most significant prognostic factor for MACE (HR 3.969, 95% CI 1.374–11.468, p = 0.011). The similar trend was observed in those with VD (HR 2.247, 95% CI 1.028–4.913, p = 0.043). Conclusion: This study demonstrated that the Z score of temporal-occipital-pariental lobe by 99mTc-ECD brain perfusion SPECT could be a potential prognostic value among patients with AF and dementia, regardless of type of dementia.
P202 Are Chinese immigrants with CVD ready to use web-based health information: a comparative study in Australia
Authors: Zhang L , Ding D , Gallagher R 
Published: January 2020

Abstract

Background
Immigrant populations often have poor access to cardiovascular disease (CVD) secondary prevention due to linguistic and cultural barriers. Web-based interventions are effective in risk reduction and lifestyle modification and may reach those hard-to-reach populations such as Chinese immigrants. However, less is known about the current use of web-based health information and confidence in use.

Purposes
We compared the use of web-based health information and confidence in use between Chinese immigrants with CVD to those with and without another chronic condition; and explored the factors associated with the confidence in utilization.

Methods
Chinese immigrants with CVD, musculoskeletal conditions, or no chronic condition were recruited from Chinese communities across New South Wales, Australia. E-health literacy scale was used to explore the perceptions of web-based health information and confidence in use. Demographic, clinical data and use of web-based health information were collected and health literacy was measured using a validated single screening question.

Results
Participants (n = 90 CVD, n = 87 musculoskeletal, n = 154 no chronic conditions) were aged mean 59 ± 16 years, mostly female (69%), 75% reported fair to poor English proficiency, and 51% had completed university. The most accessed web-based health information concerned lifestyle (60%), health resources (45%), diseases (35%), and medications (30%). More than half (54%) were confident in using web-based health information.
Participants with CVD were the oldest (71 vs 65 vs 49 years, p&lt;.001) and participants with any chronic condition had less education (p&lt;.001) and English proficiency (p&lt;.001) than the healthy group. Approximately half of the participants with CVD perceived web-based health information as useful (48%) and important (46%), and the most accessed information concerned lifestyle and medication (56% and 32%). Participants with CVD accessed medication information more often than musculoskeletal group (32% vs 23%), but there was no difference in accessing other information. Both chronic groups showed no difference in accessing web-based medication and lifestyle information compared with the healthy group. Confidence in using web-based health information was similar for CVD and musculoskeletal groups and lower than the healthy group (p&lt;.001).
Participants with the least confidence to use web-based health information were older (p=.016), female (p=.014), had less than university level education (p&lt;.001), and lower health literacy (p=.001) after adjusting for age, gender, education, English proficiency, employment status, social support, health literacy, and number of chronic conditions.
Conclusions
There is a strong potential to provide web-based medication and lifestyle information for Chinese immigrants with CVD if support is provided to improve confidence in this technology for older, women, and those with less education and/or health literacy.
P250 Evaluation of coronary endothelial dysfunction by positron emission tomography: does gender make a difference
Authors: Aljizeeri A , Alali Alfaris M , Ahmed D , Farea J , Elneama A , Suliman I , Ahmed A , Alharthi M , Alsaileek A , Al-Mallah M 
Published: January 2020

Abstract

Funding Acknowledgements
None

Introduction
Endothelial dysfunction (ED) manifested as abnormality of coronary microvasculature is associated with poor prognosis in patients presenting with chest pain. ED can be noninvasively evaluated by assessment of coronary flow reserve with positron emission tomography (PET). Studies directly comparing ED in men and women are limited. The aim of this study is to compare gender differences in ED as measured by CFR on PET myocardial perfusion imaging.

Methods
All the consecutive patients referred to PET-MPI between May 2011 and June 2018 were reviewed. Patient without known CAD who had normal perfusion were included in the analysis. Patient with abnormal electrocardiogram, significant transient ischemic dilatation, low left ventricular ejection fraction and high calcium score (&gt;1000 AU) and renal failure were excluded. CFR is calculated as the ratio of stress/rest myocardial blood flow. CFR &lt; 2 was considered as abnormal indicating the presence of ED.

Results
1711 patients were included in the analysis (mean age 60.2 ± 10 year, 68% females). Females were older and had higher BMI and diabetes (DM). Both resting and peak myocardial blood flow (MBF) was higher in females (1.16 vs 1.02 (p &lt; 0.0001)) and 3.26 vs 2.9 (p &lt; 0.001)0 respectively. Around 68% of males had abnormal CFR (&lt;2) compared to 63% of females (p = 0.05). After adjusting for the confounders, female gender was associated with higher peak MBF (Hazard ratio 0.29, 95% CI 0.19 –0.40, p &lt; 0.001) and lower chance of having ED (Hazard ratio -0.15, 95% CI -0.29 - -0.005, p = 0.049)

Conclusions
Endothelial dysfunction as measured noninvasively by CFR on PET is prevalent among both sexes. Higher level of peak MBF in females may call for a different cut-off for abnormal CFR in women. Outcome studies are required to evaluate the clinical utility and prognostic value of such a cut-off.
P271 Prophylactic administration of allopurinol with standard IV hydration in preventing contrast-induced nephropathy in patients undergoing cardiac catheterization: a meta-analysis and systematic review
Authors: Larrazabal R , Perez B B P , Chiu H C C , Tan R J T 
Published: January 2020

Abstract

Funding Acknowledgements
None

BACKGROUND
Current advancements has made contrast-guided coronary interventions widely available, however these procedures entail the risk of developing Contrast-induced nephropathy which is associated with increased morbidity and mortality of patients. One of the mechanisms that has been investigated in the development of CIN is the presence of hyperuricemia. Elevated uric acid levels may injure the microscopic tubules causing kidney injury and may induce the production of inflammatory factors furthering damage. Thus, it has been postulated that using urate lowering agents may be beneficial in preventing CIN.

OBJECTIVE
To determine the efficacy of giving oral prophylactic allopurinol along with standard IV hydration in reducing the incidence of contrast-induced nephropathy.

METHODS
We conducted a systematic literature search using PUBMED, MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Kidney and Transplant register of Studies, Google Scholar, and Research Gate. Studies fulfilling the inclusion and exclusion criteria were quality assessed based on the criteria provided in the Cochrane Handbook for Systematic Reviews of Interventions. The incidences ofContrast-Induced Nephropathy were combined and analyzed using a fixed-effect model in Review Manager (Rev Man) Version 5.3 with 95% confidence interval.

RESULTS
Five studies were included with a total of 753 patients. Results showed that there is a 63% decrease in CIN [RR = 0.37 (0.25 to 0.54, 95% CI, Z = 5.10, p &lt; 0.00001)] after prophylactic administration of allopurinol with standard IV hydration as compared to those who received hydration alone. When adjusted for heterogeneity, there remains a 35% decrease in the incidence of CIN [RR = 0.65 (0.43 to 0.99, 95% CI, Z = 2.02, p = 0.04) in patients given prophylactic allopurinol.

CONCLUSION
Oral prophylactic allopurinol administration may be protective in the development of CIN in patients undergoing coronary interventions. However larger, multi-centered randomized-controlled trials are needed to validate this claim.
Abstract P271 Figure. Forrest Plot of Study Results
Automation and jobs: when technology boosts employment*
Authors: Bessen James 
Published: January 2020

SUMMARY
Will new technologies cause industries to shed jobs, requiring novel policies to address mass unemployment? Sometimes productivity-enhancing technology increases industry employment instead. In manufacturing, jobs grew along with productivity for a century or more; only later did productivity gains bring declining employment. What changed? The elasticity of demand. Using data over two centuries for US textile, steel and auto industries, this paper shows that automation initially spurred job growth because demand was highly elastic. But demand later became satiated, leading to job losses. A simple model explains why this pattern might be common, suggesting that today’s technologies may cause some industries to decline and others to grow. Automation might not cause mass unemployment, but it may well require workers to make disruptive transitions to new industries, requiring new skills and occupations.
Automation, performance and international competition: a firm-level comparison of process innovation
Authors: Kromann Lene , Sørensen Anders 
Published: January 2020

SUMMARY
The automation of production processes is an important topic on the policy agenda in high-wage countries, and Denmark is no exception. However, the knowledge of the adoption of automation technologies across firms, of drivers of investments in automation, and on the association between automation and firm performance are limited. This paper uses a new survey to collect data on automation combined with register data to examine these issues. The variation in the adoption of automation technologies is high but the change in adoption over time is slow, and almost half of Danish manufacturing firms relied greatly on manual production processes in 2010. Increasing international competition from China is a driver for investments in automation, i.e. the manufacturing firms that are exposed to intensifying competition from China in their output markets invest more in automation than firms that are not exposed to this type of competition. We conduct external validation of the automation survey by examining the association between the automation measures and firm performance measures constructed from completely independent data sources. We find that the measures of automation are significantly associated with productivity and profitability.
BigTech and the changing structure of financial intermediation
Authors: Frost Jon , Gambacorta Leonardo , Huang Yi , Shin Hyun Song , Zbinden Pablo 
Published: January 2020

SUMMARY
Pablo Zbinden?&gt;We consider the drivers and implications of the growth of ‘BigTech’ in finance – i.e. the financial services offerings of technology companies with established presence in the market for digital services. BigTech firms often start with payments. Thereafter, some expand into the provision of credit, insurance and money management products, either directly or in cooperation with financial institution partners. Focusing on credit, we show that BigTech firms lend more in countries with less competitive banking sectors and less stringent bank regulation. Analysing the case of Argentina, we find support for the hypothesis that BigTech lenders, by acquiring a vast amount of non-traditional information, have an advantage in credit assessment relative to a traditional credit bureau. They also serve unbanked borrowers, and may have an advantage in contract enforcement. It is too early to judge the extent of BigTech’s eventual advance into the provision of financial services. However, the early evidence allows us to pose pertinent questions that bear on their impact on financial stability and overall economic welfare.
Emerging electromagnetic interferences between implantable cardioverter-defibrillators and left ventricular assist devices
Authors: Yalcin Yunus C , Kooij Claudette , Theuns Dominic A M J , Constantinescu Alina A , Brugts Jasper J , Manintveld Olivier C , Yap Sing-Chien , Szili-Torok Tamas , Bogers Ad J J C , Caliskan Kadir 
Published: January 2020

Abstract

Aims
To investigate the prevalence of electromagnetic interference (EMI) between left ventricular assist devices (LVADs) and implantable cardioverter-defibrillators (ICDs)/pacemakers (PMs).

Methods and results
A retrospective single-centre study was conducted, including all patients undergoing HeartMate II (HMII) and HeartMate 3 (HM3) LVAD implantation (n = 106). Electromagnetic interference was determined by the inability to interrogate the ICD/PM. Overall, 85 (mean age 59 ± 8, 79% male) patients had an ICD/PM at the time of LVAD implantation; 46 patients with HMII and 40 patients with HM3. Among the 85 LVAD patients with an ICD’s/PM’s, 11 patients (13%) experienced EMI; 6 patients (15%) with an HMII and 5 patients (11%) with an HM3 (P = 0.59). Electromagnetic interference from the HMII LVADs was only present in patients with a St Jude/Abbott device; 6 of the 23 St Jude/Abbott devices. However, in the HM3 patients, EMI was mainly present in patients with Biotronik devices: 4 of the 18 with only one (1/25) patient with a Medtronic device. While initial interrogation of these devices was not successful, none of the 11 cases experienced pacing inhibition or inappropriate shocks.

Conclusion
In summary, the prevalence of EMI between ICDs in the older and newer type of LVAD's remains rather high. While HMII patients experienced EMI with a St Jude/Abbott device (which was already known), HM3 LVAD patients experience EMI mainly with Biotronik devices. Prospective follow-up, preferably in large registries, is warranted to investigate the overall prevalence and impact of EMI in LVAD patients.
Age Differences in the Subcomponents of Executive Functioning
Authors: Maldonado Ted , Orr Joseph M , Goen James R M , Bernard Jessica A 
Published: January 2020

Abstract

Objectives
Across the life span, deficits in executive functioning (EF) are associated with poor behavioral control and failure to achieve goals. Though EF is often discussed as one broad construct, a prominent model of EF suggests that it is composed of three subdomains: inhibition, set shifting, and updating. These subdomains are seen in both younger (YA) and older adults (OA), with performance deficits across subdomains in OA. Therefore, our goal was to investigate whether subdomains of EF might be differentially affected by age, and how these differences may relate to broader global age differences in EF.

Methods
To assess these age differences, we conducted a meta-analysis at multiple levels, including task level, subdomain level, and of global EF. Based on previous work, we hypothesized that there would be overall differences in EF in OA.

Results
Using 1,268 effect sizes from 401 articles, we found overall differences in EF with age. Results suggested that differences in performance are not uniform, such that variability in age effects emerged at the task level, and updating was not as affected by age as other subdomains.

Discussion
These findings advance our understanding of age differences in EF, and stand to inform early detection of EF decline.
Shocks, stress and everyday health system resilience: experiences from the Kenyan coast
Authors: Kagwanja Nancy , Waithaka Dennis , Nzinga Jacinta , Tsofa Benjamin , Boga Mwanamvua , Leli Hassan , Mataza Christine , Gilson Lucy , Molyneux Sassy , Barasa Edwine 
Published: January 2020

Abstract
Health systems are faced with a wide variety of challenges. As complex adaptive systems, they respond differently and sometimes in unexpected ways to these challenges. We set out to examine the challenges experienced by the health system at a sub-national level in Kenya, a country that has recently undergone rapid devolution, using an ‘everyday resilience’ lens. We focussed on chronic stressors, rather than acute shocks in examining the responses and organizational capacities underpinning those responses, with a view to contributing to the understanding of health system resilience. We drew on learning and experiences gained through working with managers using a learning site approach over the years. We also collected in-depth qualitative data through informal observations, reflective meetings and in-depth interviews with middle-level managers (sub-county and hospital) and peripheral facility managers (n = 29). We analysed the data using a framework approach. Health managers reported a wide range of health system stressors related to resource scarcity, lack of clarity in roles and political interference, reduced autonomy and human resource management. The health managers adopted absorptive, adaptive and transformative strategies but with mixed effects on system functioning. Everyday resilience seemed to emerge from strategies enacted by managers drawing on a varying combination of organizational capacities depending on the stressor and context.
Can Dogs be Racist? The Colonial Legacies of Racialized Dogs in Kenya and Zambia
Authors: Doble Josh 
Published: January 2020

Abstract
Can dogs be racist? Posing this question may seem odd and at worst, unhelpfully provocative at a time when the discourse of ‘colour-blindness’ is so pervasive. Yet the idea of ‘racist dogs’ remains salient within the post-settler societies of eastern and southern Africa, where dogs have been an integral if overlooked tool of colonial practices of racialization. This article traces the colonial demarcation of ‘native dogs’ – juxtaposed to white settlers’ ‘pet’ dogs – to understand how racial categories were imposed on domesticated animals, and how these racialized animals were then colonized through rabies legislation. Although the formal racialization of dogs ended with the dawn of political decolonization in the early 1960s, dogs continued to be co-opted for postcolonial racial discourse. Dogs were in a prominent position in postcolonial society due to their prevalence in the security arrangements of white homes as well as in the security forces of white supremacist Rhodesia and apartheid South Africa. The intensity of the relationship between white minorities, their canine pets and the surrounding African population points toward the uncomfortable conclusion that in the heightened racial environments of decolonizing settler Africa, dogs could be made to be racist.
Klebsiella pneumoniae ST307 with OXA-181: threat of a high-risk clone and promiscuous plasmid in a resource-constrained healthcare setting
Authors: Strydom K A , Chen L , Kock M M , Stoltz A C , Peirano G , Nobrega D B , Lowe M , Ehlers M M , Mbelle N M , Kreiswirth B N , Pitout J D D 
Published: January 2020

AbstractIntroductionKlebsiella pneumoniae with OXA-48-like enzymes were introduced into Tshwane Tertiary Hospital (TTH) (Pretoria, South Africa) during September 2015, causing nosocomial outbreaks.MethodsPCR methodologies and WGS were used to characterize K. pneumoniae with carbapenemases (n = 124) from TTH (July 2015–December 2016).ResultsPCR was used to track K. pneumoniae ST307 with OXA-181 among 60% of carbapenemase-positive isolates in different wards/units over time and showed the transmission of IncX3 plasmids to other K. pneumoniae clones. WGS identified different ST307 clades: 307_OXA181 (consisting of two lineages, A and B) with OXA-181 on IncX3 plasmids (named p72_X3_OXA181) and clade 307_VIM with VIM-1 on IncFII plasmids. Clade 307_OXA181 lineage B was responsible for the rapid increase and transmission of OXA-181 K. pneumoniae in various wards/units throughout TTH, while the numbers of clade 307_OXA181 lineage A and clade 307_VIM remained low. Separate outbreaks were due to K. pneumoniae ST17 and ST29 with p72_X3_OXA181 plasmids.ConclusionsThe high-risk clone K. pneumoniae ST307 with OXA-181 rapidly spread to different wards/units despite infection and prevention measures. ST307 clades and lineages seemingly acted differently in outbreak situations. This study also highlighted the threat of promiscuous plasmids such as p72_X3_OXA181.