bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prematurity and Body Fat at 6, 18, and 30 Years of Age: Pelotas (Brazil) 2004, 1993, and 1982 Birth Cohorts
Authors: Bortolotto Caroline Cardozo , Santos Iná , Vaz Juliana dos Santos , Matijasevich Alicia , B Aluísio J.D. , Barros Fernando C. 
Published: October 2020

Abstract
Background: Our aim was to investigate the association between preterm birth and body fat at 6, 18, and 30 years of age using data from three population-based birth cohort studies. Methods: Information on gestational age (GA) gathered in the hospital of birth in the first 24-hours after the delivery was obtained for all live births occurring in the city of Pelotas, Brazil, in the years 2004, 1993 and 1982. GA was defined by the date of last menstrual period and was later categorized in ≤33, 34-36 and ≥37 weeks. Body fat was assessed by air-displacement plethysmography. Outcomes included fat mass (FM, kg), percent fat mass (%FM), fat mass index (FMI, kg/m2), and body mass index (BMI, kg/m2 at 18 years in the 1993 cohort and at 30 years in the 1982 cohort; and BMI Z-score, at 6 years in the 2004 cohort). Crude and adjusted linear regression provided beta coefficients with 95% confidence intervals (95%CI).Results: A total of 3036, 3027, and 2417 participants, respectively, from the 2004, 1993, and 1982 cohorts were analyzed. At 6 years, boys born at 34-36 weeks GA presented lower adjusted mean %FM (β: -2.91%; -4.45--1.36), FMI (β: -0.70 kg/m2 ; -1.13--0.28) and BMI Z-score (β: -0.48 kg/m2; -0.79--0.16), when compared to boys born at term (≥37). At 30 years, FM (15.6kg; 0.40-30.90), %FM (13.65%; 1.38-25.92) and FMI (5.3kg/m2; 0.30-10.37) were higher among males born at ≤33 weeks, with no statistical difference as compared to those born at term. No association was found between GA and body fat at the 1993 cohort (18 years) for both sexes. Conclusions: Given the large number of preterm infants born each year, prevention of prematurity is essential as there are possible links between body composition and diseases later in life.
HEMATOTOXIC ADVERSE DRUG REACTIONS ASSOCIATED WITH VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITORS AND CYTOTOXIC DRUGS IN THE TREATMENT OF GLIOBLASTOMA: A SYSTEMATIC REVIEW
Authors: Stepanov I. A. , Shameeva M. A. , Kruchinin D. B. , Byvaltsev V. A. , Shagdurova I. A. 
Published: October 2020

Several studies have shown that the use of inhibitors of vascular endothelial growth factor (Vascular Endothelial Gowth Factor, VEGF) in the treatment of glioblastoma results in a significant increase in the rate of progression-free survival. However, administration of anti-VEGF agents is associated with the development of a wide range of adverse drug reactions (ADR), among which, hematotoxic ADR is the most common.The purpose of this study was to conduct a systematic review based on the results of randomized controlled clinical studies on the type and frequency of hematotoxic ADRs associated with anti-VEGF and chemotherapeutic agents in the treatment of glioblastoma.Material and Methods. Pubmed, EMBASE, Cohrane Library and eLibrary databases were used to identify reports from randomized controlled clinical studies on the safety of anti-VEGF drugs as the main/auxiliary treatment for patients with glioblastoma, and published from January 2008 to August 2019. The main criteria for inclusion of studies in the systematic review were determined.Results. The combined data analysis included 13 randomized controlled clinical trials. The average incidence of hematotoxic ADRs associated with anti-VEGF agents in monotherapy for glioblastoma was 27.7 %. Neutropenia and thrombocytopenia were the most common types of ADR. The average incidence of hematotoxic ADRs associated with cytotoxic drugs in monotherapy for glioblastoma was 48.1 %, and lymphopenia and thrombocytopenia were the main types of hematotoxic ADRs. The average incidence of hematotoxic ADRs associated with the combined use of anti-VEGF and chemotherapeutic drugs was 46.2 %. In this case, the most common ADRs were thrombocytopenia, neutropenia, and anemia. The use of a combination of anti-VEGF, chemotherapeutic drugs and radiation therapy was associated with the development of hematotoxic ADRs with an average incidence of 12.3 %. The most common ADR was severe thrombocytopenia.Conclusion. The use of anti-VEGF drugs as monotherapy for glioblastoma was associated with a lower incidence of hematotoxic ADRs. In this case, bevacizumab was the safest anti-VEGF agent in relation to hematotoxicity. The highest incidence of hematotoxic ADRs is observed for a combination of antiVEGF and cytotoxic drugs, such as cediranib with lomustine and bevacizumab with carboplatin.
ASSESSMENT OF HISTOPATHOLOGICAL RESPONSE TO NEOADJUVANT CHEMORADIOTHERAPY IN GASTRIC CANCER PATIENTS: A MULTI-CENTER RANDOMIZED STUDY
Authors: Skoropad V. Yu. , Afanasyev S. G. , Gamayunov S. V. , Sokolov P. V. , Zhavoronkova Ye. S. , Silanteva N. K. , Ivanov S. A. , Kaprin A. D. 
Published: October 2020

A multicenter randomized trial was conducted to assess histopathological response to neoadjuvant chemoradiotherapy in patients with locally advanced gastric cancer.Material and Methods. Patients of the study group received conformal radiation therapy (total dose of 46 Gr/23 fractions) with concurrent chemotherapy consisted of capecitabine at a dose of 1850 mg/m2 twice daily during the whole course of radiotherapy, and oxaliplatin at a dose of 85 mg/m2 on days 1 and 21. After an interval of 4–6 weeks and a control examination, in the absence of disease progression, patients were scheduled for surgery (gastrectomy or D2 subtotal gastric resection) and 4 cycles of adjuvant chemotherapy according to the FOLFOX4 or CAPOX regimens.Results.The study included 70 patients, including of 35 patients in the study group. Men predominated (n=23), the age ranged from 22 to 76 years (median – 61 years). The middle third of the stomach was the most common tumor location (n=19); involvement of the entire stomach occurred in 5 cases. Ulcerative and diffuse infiltrative forms were the most common (n=29). Well-and moderately-differentiated adenocarcinoma was observed in 11 patients and poorly – differentiated adenocarcinoma in 24 patients, including signet ring-cell cancer (n=8). In accordance with the clinical T, N and M categories, patients were distributed as follows: T3 – 22 patients, T4a/b – 13; N0 – 13, N1 – 12, N2–3 – 10; M0 – 35; stage IIB – 12, and stage III–IVA – 23 patients. Gastrectomy was performed in 30 patients and subtotal resection of the stomach in 4 patients; D2 lymphodissection was performed in all cases. One patient was not operated on due to disease progression. Of the 47 patients achieving pathological response, 5 (14.7%) patients had a complete pathological response. Among patients achieving pathological response, a statistically significant predominance of less advanced tumors was found (in accordance with the ypT category and stage).Conclusion. In general, a decrease in the pathological tumor stage compared to clinical stage was registered in 62 % of patients. Taking into account the data available in the world literature on high survival rates in patients with pathological complete regression, the optimization and implementation of neoadjuvant therapy techniques is of great importance.
LOW-INTENSITY LASER RADIATION IN CORRECTION OF BLOOD HEMODYNAMIC AND RHEOLOGICAL PARAMETERS AFTER SURGERY FOR HEAD AND NECK CANCER
Authors: Gorchak Yu. Yu. , Stakhanov M. L. , Gens G. P. , Firsov K. A. , Reshetov D. N. , Gainedinov S. M. , Kurnosov A. A. , Korobkova A. Yu. , Korobkova L. I. 
Published: October 2020

Purpose: to study the effect of low-level laser therapy (LLLT) in correction of blood hemodynamic and rheological parameters after surgery for head and neck cancer.Material and Methods. The study included 134 head and neck cancer patients with a median age of 54.24 ± 12.7 years (range: 23–78 years). There were 39 (29.1 %) men and 95 (70.9 %) women. To assess the effectiveness of LLLT, all patients were divided into 3 groups. Group I included 45 patients, who received conventional therapy without the use of LLLT. Group II consisted of 45 patients, who received conventional therapy in combination with LLLT. Group III included 44 patients, who received LLLT alone. Azor 2K-02 was used as a source of LLLT in the red to near infrared spectral range. Characteristics of blood flow in the vessels of the neck and the rheological properties of blood, as well as the parameters of spontaneous platelet aggregation and the content of soluble fibrinmonomer complexes in the blood plasma of patients were studied.Results. The data obtained indicated that the use of LLLT promoted normalization of blood rheological properties in patients, who underwent surgery. Normalization of blood rheological properties occurred faster and lasted for a longer period. In patients, who received conventional therapy in combination with LLLT, the hemodynamic and rheological parameters of blood were improved 2–14 days after therapy, whereas in patients receiving conventional therapy alone, this improvement was seen 30 or more days after therapy.Conclusion. LLLT in combination with conventional therapy was shown to have a positive effect on hemodynamic and rheological parameters after surgery for head and neck cancer.
LEVELS I–VII FOLLOWING THYROIDECTOMY FOR PAPILLARY THYROID CANCER
Authors: Parshin V. S. , Veselova A. A. , Medvedev V. S. , Ivanov S. A. , Kaprin A. D. 
Published: October 2020

Introduction. Cervical lymph node metastases can occur not only in patients when they are first diagnosed with papillary thyroid cancer but also in patients who have undergone thyroidectomy. Objective. The aim of this study was to assess the potential utility of neck ultrasound in diagnosing cervical lymph node metastases (levels I–VII) in patients who underwent surgical treatment for papillary thyroid cancer.Material and Methods. B-mode sonography of all nodal levels in the neck was performed using a linear array transducer in the frequency range of 7.5–13 MHz, power mapping and panoramic scan to locate regional lymph node metastases. All lymph nodes removed during reoperations were submitted for histological evaluation. Sonographic examinations of cervical lymph nodes of the levels I–VII were performed in 2875 patients who had undergone thyroidectomy in different regions of the Russian Federation. The patients were admitted to our clinic to receive radioactive iodine therapy. All neck levels were assessed by ultrasound.Results. Sonography revealed cervical lymph node metastases in 267 (9.2 %) of 2875 patients with papillary thyroid cancer who had undergone thyroidectomy. Nodal metastasis in level VI only occurred in 70 (2.4 %) patients, in levels II–III–IV only in 150 (5.21 %), in level VB only in 32 (1.11 %), and at the same time in level VI and in levels II–III–IV in 15 (0.52 %) patients. There were no metastases in levels I, VA, VII of the neck. Solitary metastases to all levels were found in 7.5 %, multiple metastases in 1.2 %, and conglomerates in 0.6 % of cases. Solitary metastases in level VI were noted in 56 (1.9 %), in levels II–III–IV in 125 (4.3 %), and in level VB in 29 (1.0 %) patients. Multiple metastases in level VI were detected in 11 (0.38 %), in levels II–III–IV in 21 (0.73 %), and in level VB in 3 (0.1 %) patients. Median metastasis size was 2.1 ± 1.6 cm.Conclusion. Post-thyroidectomy patients were found to have cervical lymph node metastases. Ultrasound scanning of the neck should be considered a key examination if there are cicatricial changes as it enables to identify metastasis and to determine its location. The maximal number of metastases was noted in levels II–III–IV. Cervical lymph node metastases occurred less frequently in the central level and level VB. The predominant metastatic pattern was solitary. There was an essential difference in metastatic spread to cervical lymph nodes between postthyroidectomy patients and patients who were first diagnosed with papillary thyroid cancer.
METHODS FOR SENTINEL LYMPH NODE DETECTION IN PATIENTS WITH BREAST CANCER
Authors: Zikiryakhodzhaev A. D. , Grushina T. I. , Starkova M. V. , Kazaryan L. P. , Volkova Yu. I. , Bagdasarova D. V. , Ablitsova N. V. , Skreptsova N. S. , Usov F. N. 
Published: October 2020

Objective: to provide various methods for sentinel lymph node detection considering their advantages and disadvantages.Material and Methods. The search of the relevant articles published in Pubmed, MedLine, RINTs, etc. database was conducted. 49 publications from 1970 to 2018 were analyzed.Results. Currently, sentinel lymph node biopsy (SLN biopsy) has become a worthy alternative to traditional lymphatic surgery for early breast cancer. SLN biopsy significantly decreases the number of postoperative complications caused by lymphadenectomy and improves the quality of life of cancer patients. So far, a large number of SLN detection techniques have accumulated. Each of these techniques has its own advantages and disadvantages.Conclusion. Despite a large number of SLN detection methods, the question of the optimal technique is currently debatable.
Performance of electrochemical oxidation over BDD anode for the treatment of different industrial dye-containing wastewater effluents
Authors: Abdelhay Arwa , Jum'h Inshad , Albsoul Abeer , Abu Arideh Dina , Qatanani Bahaa 
Published: October 2020

Abstract
This paper presents the results of electrochemical oxidation of dye-containing wastewater over a BDD anode. Batch experiments were conducted at a fixed current density of 2.8 mA/cm2 to analyze the performance of the electrochemical process for the treatment of textile and paint wastewater utilizing different supporting electrolytes (Na2SO4 and NaCl). During electrolysis, emphasis was put on measuring different parameters such as chemical oxygen demand (COD), turbidity, conductivity, and color removal. The results revealed that BDD cell exhibited higher COD removal efficiency for textile wastewater than for paint wastewater. Adding supporting electrolytes had a positive effect on COD, turbidity, and color removal efficiencies for both textile and paint industry effluents. For textile wastewater, Na2SO4 and NaCl yielded a reduction in COD of 94% in 6 hours compared to 84% with no electrolyte added. The presence of Na2SO4 and NaCl in paint wastewater resulted in different COD removal percentages of 71 and 85% respectively with 21% in raw sample after 4 hours of treatment. The discoloration reached a percentage higher than 96% for both effluents and for both electrolytes. Under the same experimental conditions, all cases showed turbidity removal higher than 97%. The kinetic study showed that the reaction rate followed pseudo-first-order kinetics.
Evaluation of water security based on capacity for socio-economic regulation
Authors: Tang Lian , Zhang Weibing , Liu Zixi , Qi Yarong 
Published: October 2020

Abstract
From the perspective of social and economic regulation, the development trend of regional water security in different periods and under different regulation strengths is evaluated by using the fuzzy set pair analysis method. The results show: the degree of regional water resources security changes from insecurity in the pilot period of water-saving society construction to basic security, and then to security in the planning period, with the enhancement of economic and social regulation. The order of importance of each index is C19 &gt; C1 = C5 &gt; C18 &gt; C14 &gt; C10 &gt; C13 &gt; C3 = C4 &gt; C8 &gt; C7 &gt; C15 &gt; C16 &gt; C12 &gt; C2 &gt; C11 &gt; C17 &gt; C6 &gt; C9, the long-term shortage of water resources is the most important factor, the contribution rate is 60%, but the index weight of economic and social coordination ability is large, and its rapid change causes the improvement of water resources security; the contradiction between the regulation intensity of social and economic indicators in the planning year and the demand for water resources is not matched, and the degree of water security is mainly restricted by the shortage of regional water resources.
A experiência amorosa como rito de passagem dentro do processo de individuação feminino
Authors: Cirineu Ana Lūcia 
Published: October 2020

O presente trabalho teve como objetivo refletir sobre a experiência amorosa tal como ela é vivida pelas mulheres, ressaltando essa trajetória como um processo único e de grande importância no desenvolvimento da psique feminina. A escolha por analisar especificamente a experiência amorosa feminina partiu do pressuposto de que ela se dá de forma diferente daquela do desenvolvimento masculino. Na mulher, o amor configura-se como um rito iniciático que a coloca na jornada da individuação, já o homem, no decorrer de seu desenvolvimento, depara-se com outras formas de iniciação. A pesquisa aqui desenvolvida investigou de que forma a experiência amorosa serve como rito de passagem para o caminho de individuação feminino, explorando mais precisamente o sofrimento enquanto marca principal desse rito de passagem. A partir do mito de Eros e Psiquê, analisou-se o caminho percorrido pela mulher na descoberta de si mesma, considerando o sofrimento experimentado no decorrer do processo como necessário e facilitador do encontro com o animus, o que, consequentemente, contribui para o processo de tomada de consciência e para a busca autônoma da individuação feminina.
Mobile Apps for Speech-Language Therapy in Adults With Communication Disorders: Review of Content and Quality
Authors: Vaezipour Atiyeh , Campbell Jessica , Theodoros Deborah , Russell Trevor 
Published: October 2020

Background
Worldwide, more than 75% of people with acquired brain injury (ABI) experience communication disorders. Communication disorders are impairments in the ability to communicate effectively, that is, sending, receiving, processing, and comprehending verbal and nonverbal concepts and symbols. Such disorders may have enduring impacts on employment, social participation, and quality of life. Technology-enabled interventions such as mobile apps have the potential to increase the reach of speech-language therapy to treat communication disorders. However, ensuring that apps are evidence-based and of high quality is critical for facilitating safe and effective treatment for adults with communication disorders.

Objective
The aim of this review is to identify mobile apps that are currently widely available to adults with communication disorders for speech-language therapy and to assess their content and quality using the validated Mobile App Rating Scale (MARS).

Methods
Google Play Store, Apple App Store, and webpages were searched to identify mobile apps for speech-language therapy. Apps were included in the review if they were designed for the treatment of adult communication disorders after ABI, were in English, and were either free or for purchase. Certified speech-language pathologists used the MARS to assess the quality of the apps.

Results
From a total of 2680 apps identified from Google Play Store, Apple App Store, and web searches, 2.61% (70/2680) apps met the eligibility criteria for inclusion. Overall, 61% (43/70) were available for download on the iPhone Operating System (iOS) platform, 20% (14/70) on the Android platform, and 19% (13/70) on both iOS and Android platforms. A content analysis of the apps revealed 43 apps for language, 17 apps for speech, 8 apps for cognitive communication, 6 apps for voice, and 5 apps for oromotor function or numeracy. The overall MARS mean score was 3.7 out of 5, SD 0.6, ranging between 2.1 and 4.5, with functionality being the highest-scored subscale (4.3, SD 0.6), followed by aesthetics (3.8, SD 0.8), information (3.4, SD 0.6), and engagement (3.3, SD 0.6). The top 5 apps were Naming Therapy (4.6/5), Speech Flipbook Standard (4.6/5), Number Therapy (4.5/5), Answering Therapy, and Constant Therapy (4.4/5).

Conclusions
To our knowledge, this is the first study to systematically identify and evaluate a broad range of mobile apps for speech-language therapy for adults with communication disorders after sustaining ABI. We found a lack of interactive and engaging elements in the apps, a critical factor in sustaining self-managed speech-language therapy. More evidence-based apps with a focus on human factors, user experience, and a patient-led design approach are required to enhance effectiveness and long-term use.
Associations Between Patient Health Outcomes and Secure Message Content Exchanged Between Patients and Clinicians: Retrospective Cohort Study
Authors: Heisey-Grove Dawn M , McClelland Laura E , Rathert Cheryl , Tartaglia Alexander , Jackson Kevin , DeShazo Jonathan P 
Published: October 2020

Background
The number of electronic messages securely exchanged between clinic staff and patients has risen dramatically over the last decade. A variety of studies explored whether the volume of messages sent by patients was associated with outcomes. None of these studies, however, examined whether message content itself was associated with outcomes. Because secure messaging is a significant form of communication between patients and clinic staff, it is critical to evaluate the context of the communication to best understand its impact on patient health outcomes.

Objective
To examine associations between patients’ and clinicians’ message content and changes in patients’ health outcomes.

Methods
We applied a taxonomy developed specifically for secure messages to 14,394 patient- and clinic staff–generated messages derived from patient-initiated message threads. Our study population included 1602 patients, 50.94% (n=816) of whom initiated message threads. We conducted linear regression analyses to determine whether message codes were associated with changes in glycemic (A1C) levels in patients with diabetes and changes in systolic (SBP) and diastolic (DBP) blood pressure in patients with hypertension.

Results
Patients who initiated threads had larger declines in A1Cs (P=.01) compared to patients who did not initiate threads. Clinic nonresponse was associated with decreased SBP (β=–.30; 95% CI –0.56 to –0.04), as were staffs’ action responses (β=–30; 95% CI –0.58 to –0.02). Increased DBP, SBP, and A1C levels were associated with patient-generated appreciation and praise messages and staff encouragement with effect sizes ranging from 0.51 (A1C) to 5.80 (SBP). We found improvements in SBP associated with patients’ complaints (β=–4.03; 95% CI –7.94 to –0.12). Deferred information sharing by clinic staff was associated with increased SBP (β=1.29; 95% CI 0.4 to 2.19).

Conclusions
This is the first research to find associations between message content and patients’ health outcomes. Our findings indicate mixed associations between patient message content and patient outcomes. Further research is needed to understand the implications of this work; in the meantime, health care providers should be aware that their message content may influence patient health outcomes.