bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes
Authors: Gillberg Linn , Ørskov Andreas D. , Nasif Ammar , Ohtani Hitoshi , Madaj Zachary , Hansen Jakob W. , Rapin Nicolas , Mogensen Johanne B. , Liu Minmin , Dufva Inge H. , Lykkesfeldt Jens , Hajkova Petra , Jones Peter A. , Grønbæk Kirsten 
Published: October 2019

Abstract

Background
Patients with haematological malignancies are often vitamin C deficient, and vitamin C is essential for the TET-induced conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), the first step in active DNA demethylation. Here, we investigate whether oral vitamin C supplementation can correct vitamin C deficiency and affect the 5hmC/5mC ratio in patients with myeloid cancers treated with DNA methyltransferase inhibitors (DNMTis).

Results
We conducted a randomized, double-blinded, placebo-controlled pilot trial (NCT02877277) in Danish patients with myeloid cancers performed during 3 cycles of DNMTi-treatment (5-azacytidine, 100 mg/m2/d for 5 days in 28-day cycles) supplemented by oral dose of 500 mg vitamin C (n = 10) or placebo (n = 10) daily during the last 2 cycles. Fourteen patients (70%) were deficient in plasma vitamin C (< 23 μM) and four of the remaining six patients were taking vitamin supplements at inclusion. Global DNA methylation was significantly higher in patients with severe vitamin C deficiency (< 11.4 μM; 4.997 vs 4.656% 5mC relative to deoxyguanosine, 95% CI [0.126, 0.556], P = 0.004). Oral supplementation restored plasma vitamin C levels to the normal range in all patients in the vitamin C arm (mean increase 34.85 ± 7.94 μM, P = 0.0004). We show for the first time that global 5hmC/5mC levels were significantly increased in mononuclear myeloid cells from patients receiving oral vitamin C compared to placebo (0.037% vs − 0.029%, 95% CI [− 0.129, − 0.003], P = 0.041).

Conclusions
Normalization of plasma vitamin C by oral supplementation leads to an increase in the 5hmC/5mC ratio compared to placebo-treated patients and may enhance the biological effects of DNMTis. The clinical efficacy of oral vitamin C supplementation to DNMTis should be investigated in a large randomized, placebo-controlled clinical trial.

Trial registration
ClinicalTrials.gov, NCT02877277. Registered on 9 August 2016, retrospectively registered.
KIF5B modulates central spindle organization in late-stage cytokinesis in chondrocytes
Authors: Gan Huiyan , Xue Wenqian , Gao Ya , Zhu Guixia , Chan Danny , Cheah Kathryn S. E. , Huang Jiandong 
Published: October 2019

Abstract

Background
The growth plate is a special region of the cartilage that drives longitudinal growth of long bones. Proliferating chondrocytes in the growth plate, arranged in columns, divide perpendicular to the long axis of the growth plate then intercalate to re-align with parental columns. Which molecular partners maintain growth plate columnar structures and chondrocyte cytokinesis has not been fully revealed. It is reported that kinesin family member 3A (KIF3A), a subunit of kinesin-2, plays an important role in maintaining columnar organization in growth plates via controlling primary cilia formation and cell proliferation.

Result
Here we identify kinesin family member 5B (KIF5B), the heavy chain of kinesin-1, a ubiquitously expressed motor protein for anterograde intracellular transport along the microtubule network, as a key modulator of cytokinesis in chondrocytes via maintenance of central spindle organization. We show that KIF5B is concentrated in the central spindle during cytokinesis in both primary chondrocytes and chondrogenic ATDC5 cells.

Conclusion
The failure of cytokinesis in KIF5B null chondrocytes leads to incomplete cell rotation, disrupting proliferation and differentiation, and results in a disorganized growth plate.
Hadamard k-fractional inequalities of Fejér type for GA-s-convex mappings and applications
Authors: Lei Hui , Hu Gou , Cao Zhi-Jie , Du Ting-Song 
Published: October 2019

Abstract
The main aim of this paper is to establish some Fejér-type inequalities involving hypergeometric functions in terms of GA-s-convexity. For this purpose, we construct a Hadamard k-fractional identity related to geometrically symmetric mappings. Moreover, we give the upper and lower bounds for the weighted inequalities via products of two different mappings. Some applications of the presented results to special means are also provided.
Least energy sign-changing solutions for Kirchhoff–Poisson systems
Authors: Chai Guoqing , Liu Weiming 
Published: October 2019

Abstract
The paper deals with the following Kirchhoff–Poisson systems:
$$ \textstyle\begin{cases} - ( {1+b\int _{{\mathbb{R}}^{3}} { \vert \nabla u \vert ^{2}\,dx} } ) \Delta u+u+k(x)\phi u+\lambda \vert u \vert ^{p-2}u=h(x) \vert u \vert ^{q-2}u, & x\in {\mathbb{R}}^{3}, \\ -\Delta \phi =k(x)u^{2}, & x\in {\mathbb{R}}^{3}, \end{cases} $$

{

−
(
1
+
b

∫

R
3

|
∇
u

|
2

d
x
)
Δ
u
+
u
+
k
(
x
)
ϕ
u
+
λ
|
u

|

p
−
2

u
=
h
(
x
)
|
u

|

q
−
2

u
,

x
∈

R
3

,

−
Δ
ϕ
=
k
(
x
)

u
2

,

x
∈

R
3

,

where the functions k and h are nonnegative, $0\le \lambda , b$
0
≤
λ
,
b
; $2\le p\le 4< q<6$
2
≤
p
≤
4
<
q
<
6
. Via a constraint variational method combined with a quantitative lemma, some existence results on one least energy sign-changing solution with two nodal domains to the above systems are obtained. Moreover, the convergence property of $u_{b}$

u
b

as $b \searrow 0$
b
↘
0
is established.
A segmented Adomian algorithm for the boundary value problem of a second-order partial differential equation on a plane triangle area
Authors: Yun Yin-shan , Wen Ying , Chaolu Temuer , Rach Randolph 
Published: October 2019

Abstract
For the boundary value problem (BVP) of a second-order partial differential equation on a plane triangle area, we propose a new algorithm based on the Adomian decomposition method (ADM) combined with a segmented technique. In addition, we present a new theorem that ensures the convergence of the algorithm. By this algorithm, the model for the effect of regional recharge on the plane triangle groundwater flow region is solved, from which we obtain the segmented exact solution of the problem, which satisfies the governing equation and all of the specified boundary conditions. Then, by the algorithm combined with Taylor’s formula, the heterogeneous aquifer model on the plane triangle groundwater flow region is considered, from which we obtain the segmented high-precision approximate solution of the problem.
Solitons for the modified $(2 + 1)$-dimensional Konopelchenko–Dubrovsky equations
Authors: Lyu Xiumei , Gu Wei 
Published: October 2019

Abstract
In the paper, we consider the modified $(2 + 1)$
(
2
+
1
)
-dimensional Konopelchenko–Dubrovsky equations which possess high order nonlinear terms. Under the aid of Maple, we derive the exact traveling wave solutions of the mKDs by the auxiliary equation approach. Under some special conditions, Jacobi elliptic function solutions, degenerated triangular function solutions, and solitons for the mKD equations are constructed.
Some symmetries, similarity solutions and various conservation laws of a type of dispersive water waves
Authors: Zhang Yufeng , Bai Na , Guan Hongyang 
Published: October 2019

AbstractWe investigate the point symmetries, Lie–Bäcklund symmetries for a type of dispersive water waves. We obtain some Lie transformation groups, various group-invariant solutions, and some similarity solutions. Besides, we produce different formats of conservation laws of the dispersive water waves by using different schemes. Finally, we consider some special solutions of the stationary dispersive water-wave equations.
Effect of a pedometer-based walking challenge on increasing physical activity levels amongst hospital workers
Authors: Al-Mohannadi Abdulla S. , Sayegh Suzan , Ibrahim Izzeldin , Salman Ahmad , Farooq Abdulaziz 
Published: October 2019

Abstract

Background
More than 50% of Qatari adults are physically inactive. The workplace is an excellent environment to implement cost-effective, efficient behavioural physical activity (PA) interventions to increase PA. This study evaluated whether a pedometer-based walking challenge would increase PA levels amongst hospital workers.

Methods
A pedometer-based workplace walking intervention was implemented in April–August 2017. Amongst 800 recruited full-time hospital workers, a cross-sectional sample of 212 workers completed the online questionnaires Quality of Life Questionnaire, International Physical Activity Questionnaire (IPAQ), and Workforce Sitting Questionnaire. A sub-sample of participants (n = 54) wore a pedometer for 3 months. They recorded their daily step count through an online web platform linked to the pedometer. Another cross-sectional sample (n = 194) in the same target population completed online questionnaires at post intervention.

Results
The IPAQ assessed physical activity at post-intervention was higher compared to pre-intervention. In a sub-sample (n = 54) that provided pedometer data, workers’ step count during intervention was significantly higher (9270) from pre-intervention (7890) (p = 0.048).

Conclusions
Although self-reported PA was higher post-intervention, the subsample showed objectively assessed physical activity did not exceed the threshold recommended for optimal health. Therefore, encouraging participation and maintaining motivation amongst workers in a work-based PA programme is challenging.
Improvement of fiber optic based localized surface plasmon resonance sensor by optical fiber surface etching and Au capping
Authors: Bae Se-Woong , Kim Hyeong-Min , Park Jae-Hyoung , Lee Seung-Ki 
Published: October 2019

Abstract
Fiber optic based localized surface plasmon resonance (FO-LSPR) sensor is one of the biosensors that detects specific biomolecules and can detect the onset of disease. In this paper, we propose two methods to improve the signal to noise ratio (SNR) of the sensor, which is one of the main characteristics of the FO-LSPR sensor. The first method is to increase the intensity of the sensor by increasing the size of gold nanoparticle (Au NP) formed on the optical fiber surface by Au capping method. The second method is to form a structure that reduces the reflection by increasing the roughness of the surface by etching the surface of the optical fiber using the Au NP formed on the surface of the optical fiber as a mask. Increasing the roughness of the optical fiber surface can reduce the background signal of the sensor. The two methods mentioned above can increase the SNR of the sensor. When the SNR of the sensor is increased, the efficiency of the sensor is improved.
Casing failure identification of long-abandoned geothermal wells in Field Dieng, Indonesia
Authors: Marbun B. T. H. , Ridwan R. H. , Sinaga S. Z. , Pande B. , Purbantanu B. A. 
Published: October 2019

Abstract
Integrity issues create challenges for maintaining the production of mature geothermal wells. Such problems are likely to occur in wells designed according to oil and gas standards, without considering the extreme geothermal environment. PT Geo Dipa Energi as the operator of the Dieng geothermal field, one of the longest operated in Indonesia, has experienced this difficulty since acquiring the field. Almost half of the production wells have been abandoned because of casing issues. To increase production, the operator plans to reactivate wells that have been previously abandoned. An initial study was performed to assess the technical feasibility of reactivating wells at Dieng; it included the development of a well assessment methodology including casing design, comprising historical data analysis, identification of well problems, and investigation of well integrity. The study focused on the identification and characterization of two abandoned wells, HCE9B and HCE28B, current casing conditions, limitations, and challenges to perform a well intervention and workover which is realistic, measurable, economic, and technically feasible. The result of this study will be applicable for casing design for future wells.
Improving the performance of support-vector machine by selecting the best features by Gray Wolf algorithm to increase the accuracy of diagnosis of breast cancer
Authors: Kamel Seyed Reza , YaghoubZadeh Reyhaneh , Kheirabadi Maryam 
Published: October 2019

Abstract
One of the most common diseases among women is breast cancer, the early diagnosis of which is of paramount importance. Given the time-consuming nature of the diagnosis process of the disease, using new methods such as computer science is extremely important for early detection of the condition. Today, the main emphasis is on the science of data mining as one of the computer methods in the field of diagnosis. In the present study, we used data mining as a combination of feature selection method by Gray Wolf Optimization (GWO) and support vector machine (SVM), which is a new technique with high accuracy compared to other methods in this classification, to increase the accuracy of breast cancer diagnosis. The UCI dataset and functional parameters and various statistical criteria were applied to evaluate the proposed method and assess the validity of the results in MATLAB, respectively. Application of the proposed method increased the improvement of the evaluated criteria, which increased the accuracy of diagnosis by 27.68%, compared to former works in the field. As such, it could be concluded that the proposed method had a higher ability to diagnose breast cancer, compared to previous techniques.
Emotion analysis of Arabic tweets using deep learning approach
Authors: Baali Massa , Ghneim Nada 
Published: October 2019

Abstract
Nowadays, sharing moments on social networks have become something widespread. Sharing ideas, thoughts, and good memories to express our emotions through text without using a lot of words. Twitter, for instance, is a rich source of data that is a target for organizations for which they can use to analyze people’s opinions, sentiments and emotions. Emotion analysis normally gives a more profound overview of the feelings of an author. In Arabic Social Media analysis, nearly all projects have focused on analyzing the expressions as positive, negative or neutral. In this paper we intend to categorize the expressions on the basis of emotions, namely happiness, anger, fear, and sadness. Different approaches have been carried out in the area of automatic textual emotion recognition in the case of other languages, but only a limited number were based on deep learning. Thus, we present our approach used to classify emotions in Arabic tweets. Our model implements a deep Convolutional Neural Networks (CNN) trained on top of trained word vectors specifically on our dataset for sentence classification tasks. We compared the results of this approach with three other machine learning algorithms which are SVM, NB and MLP. The architecture of our deep learning approach is an end-to-end network with word, sentence, and document vectorization steps. The deep learning proposed approach was evaluated on the Arabic tweets dataset provided by SemiEval for the EI-oc task, and the results-compared to the traditional machine learning approaches-were excellent.
The decreased SIRT1 level may account for the lipid profile in chronic kidney disease
Authors: Chen Gang , Li Xuemei 
Published: October 2019

AbstractDysregulated lipid profile with hypertriglyceridemia and increased low-density lipoprotein (LDL) is common in chronic kidney disease (CKD) whereas the reason is unclear. A similar phenomenon is found in the elder population. Silent information regulator-1 (SIRT1) associates with many modulators regulating lipid metabolism and results in increased expression of sterol regulatory element-binding proteins (SREBPs), which functions as a key modulator in lipid synthesis. Since CKD is being viewed as a premature aging model and SIRT1 is known to decrease during the process of aging, we hypothesize that SIRT1 level is reduced in the liver when CKD develops and eventually result in dysregulated lipid profile.
Rayleigh wave propagation in transversely isotropic magneto-thermoelastic medium with three-phase-lag heat transfer and diffusion
Authors: Kaur Iqbal , Lata Parveen 
Published: October 2019

AbstractThe present research deals with the propagation of Rayleigh wave in transversely isotropic magneto-thermoelastic homogeneous medium in the presence of mass diffusion and three-phase-lag heat transfer. The wave characteristics such as phase velocity, attenuation coefficients, specific loss, and penetration depths are computed numerically and depicted graphically. The normal stress, tangential stress components, temperature change, and mass concentration are computed and drawn graphically. The effects of three-phase-lag heat transfer, GN type-III, and LS theory of heat transfer are depicted on the various quantities. Some particular cases are also deduced from the present investigation.
Phase II study of R–CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma: consortium for improving survival of lymphoma (CISL) study
Authors: Oh Sung Yong , Kim Won Seog , Kim Jin Seok , Kim Seok Jin , Yoon Dok Hyun , Yang Deok‐Hwan , Lee Won Sik , Kim Hyo Jung , Yhim Ho‐Young , Jeong Seong Hyun , Won Jong Ho , Lee Suee , Kong Jee Hyun , Lim Sung‐Nam , Ji Jun Ho , Kwon Kyung A. , Lee Gyeong‐Won , Lee Jae Hoon , Lee Ho Sup , Shin Ho‐Jin , Suh Cheolwon 
Published: October 2019

AbstractBackgroundThe response rate and survival improvement for rituximab, a CD20‐targeting monoclonal antibody, have been demonstrated in marginal zone lymphoma (MZL) as monotherapy and in combination with chemotherapeutic regimens, yet relapses still occur despite treatment completion. Thus, extending the period of remission in MZL patients remains an essential goal. This multicenter, single‐arm, open‐label phase II study evaluated the survival efficacy of 2 years of rituximab‐maintenance therapy in patients with stage III–IV CD20‐positive MZL who had responded to first‐line R–CVP (rituximab, cyclophosphamide, vincristine, and prednisolone). The objective of this study was to determine whether rituximab maintenance following R–CVP warrants further investigation.MethodsPrior to rituximab‐maintenance therapy, patients received 6–8 cycles of first‐line R–CVP therapy for stage III–IV MZL. Rituximab (375 mg/m2), cyclophosphamide (750 mg/m2), and vincristine (1.4 mg/m2; maximum 2 mg) were administered via an intravenous infusion on day 1 of each 3‐week cycle, while oral prednisolone (100 mg) was given on days 1–5 of each 3‐week cycle. The patients who achieved complete response (CR), partial response (PR), or stable disease (SD) to R–CVP treatment, were prescribed rituximab‐maintenance therapy which was administered intravenously at a dose of 375 mg/m2 every 8 weeks for up to 12 cycles. The primary endpoint was progression‐free survival (PFS). Secondary endpoints were overall survival (OS) and treatment safety.Results47 patients were enrolled, of whom, 45 (96%) received rituximab‐maintenance treatment. Fifteen (33%) patients had nodal MZL. Following R–CVP first‐line therapy, 20 (44%), 22 (49%), and 3 (7%) patients achieved CR, PR, and SD, respectively. After a median follow‐up of 38.2 months, their observed 3‐year PFS rate was 81%. During the rituximab‐maintenance, 6 PR and 1 SD patients achieved CR following the administration of R–CVP. Elevated LDH and the presence of B symptoms were found to be significant prognostic factors for PFS (P= 0.003) and demonstrated a 3‐year OS rate of 90%. Rituximab‐maintenance therapy was well tolerated, and the common treatment‐emergent adverse events were sensory neuropathy (18%), myalgia (13%), fatigue (9%), and neutropenia (9%).ConclusionRituximab‐maintenance therapy following first‐line R–CVP demonstrated good PFS in patients with stage III–IV MZL, in addition to a favorable toxicity profile.Trial registration clinicaltrials.gov: NCT01213095
Application of botulinum toxin in maxillofacial field: Part II. Wrinkle, intraoral ulcer, and cranio-maxillofacial pain
Authors: Kwon Kyung-Hwan , Shin Kyung Su , Yeon Sung Hee , Kwon Dae Gun 
Published: October 2019

Abstract
Botulinum toxin (BTX) is used in various ways such as temporarily resolving muscular problems in musculoskeletal temporomandibular disorders, inducing a decrease in bruxism through a change in muscular patterns in a patient’s bruxism, and solving problems in patients with tension headache. And also, BTX is widely used in cosmetic applications for the treatment of facial wrinkles after local injection, but conditions such as temporomandibular joint disorders, headache, and neuropathic facial pain could be treated with this drug. In this report, we will discuss the clinical use of BTX for facial wrinkle, intraoral ulcer, and cranio-maxillofacial pain with previous studies and share our case.
Extra-pleural solitary fibrous tumors: a review
Authors: Almeida Costa Nuno , Fonseca Diogo , Santos João 
Published: October 2019

Abstract
Solitary fibrous tumor (SFT) is a rare mesenchymal ubiquitous tumor reported in the pleura and a wide variety of extrapleural locations, most frequently in the orbits and extremities.
Approximately 78–88% of SFTs are benign and 12–22% are malignant.
Although tumor characteristics are highly dependent on the location there are unifying features in MR imaging suggesting SFT: well-circumscribed, often lobulated nodular lesion, delayed contrast enhancement and the presence of fibrous contents which are hypointense on T1 and T2-weighted MRI imaging.
There are many SFT differential diagnosis, highly dependent to the tumor location. Due to its rarity the diagnosis of extrapleural SFTs may be challenging. Histopathologic analysis is always required to confirm the diagnosis and to allow the distinction between the benign and malignant forms.
We review pleural and extrapleural SFTs, presenting diagnostic clues, differential diagnosis and prognostic factors.