bluuebunny/crossref_metadata_2025_split huggingface dataset:
The study on analysis of risk factors for severity of white matter lesions and its correlation with cerebral microbleeds in the elderly with lacunar infarction
Authors: Zhou Yu-Ni , Gao Hao-Yuan , Zhao Fang-Fang , Liang Ying-Chun , Gao Yuan , Liu Xin-Hong , Wang Tao , Wang Zhi-Gao , Wu Qing-Jian 
Published: January 2020

Abstract
This study aimed to explore the risk factors for severity of white matter lesions and its correlation with in the elderly with lacunar infarction.
Patients (range, 70–85 years) with lacunar infarction treated in a hospital in China from 2016 to 2017were enrolled. Fazekas rating scale (0–6 points) was used to assess severity of white matter lesions. Risk factors for the severity of white matter lesions and correlation between cerebral microbleeds and white matter lesions in the elderly with lacunar infarction were studied.
The elderly (81–85 years’ old, odds ratio [OR]: 2.423, 95% confidence interval [CI]: 1.795–3.271, P = .018; 76∼80 years’ old, OR: 3.113, 95% CI: 1.723–5.625, P = .043), carotid atherosclerosis (OR: 3.062, 95% CI:1.715–5.468, P < .001), history of hypertension (OR: 3.694, 95% CI: 2.031–6.717, P < .001) were risk factors for the severity of white matter lesions. The white matter lesions score increased corresponding to increase in the cerebral microbleeds grade (P < .001). The white matter lesions score was higher in the cerebral microbleeds combined with the white matter lesions group than in the white matter lesions group (P < .01). After correcting the effects of age, there was a correlation between white matter lesions and cerebral microbleeds (P < .001). Logistic analysis revealed that the patients’ age (81–85 years’ old, OR: 2.722, 95% CI: 1.985–3.734, P = .019; 76∼80 years’ old, OR: 1.857, 95% CI: 1.075–3.207, P = .031), history of hypertension (OR: 2.931, 95% CI: 1.136–7.567, P = 0.0.036), systolic blood pressure (OR: 1.049, 95% CI: 1.015–1.084, P = .007), high-sensitivity C-reactive protein (OR: 1.504, 95% CI: 1.254–1.803, P < .001), homocysteine (OR: 1.076, 95% CI: 1.020–1.136, P = .009), and carotid atherosclerosis (OR: 1.389, 95% CI: 1.103–1.748, P = .010) were significant risk factors for combined cerebral microbleeds with white matter lesions in patients with lacunar infarction.
The elderly, carotid atherosclerosis, history of hypertension were risk factors for the severity of white matter lesions. Cerebral microbleeds were positively correlated with the severity of white matter lesions.
Clinical outcomes of nonsurgical treatment for Preiser disease
Authors: Tomori Yuji , Nanno Mitsuhiko , Takai Shinro 
Published: January 2020

Abstract
To elucidate whether nonsurgical treatment for Preiser disease is effective.
Eight patients with Preiser disease (median age 59 [47–69] years
) underwent nonsurgical treatment (median symptom-onset-to-treatment interval 8 [9–180] months). At presentation, 7 patients complained of constant pain and 1 of motion-related pain. Pain restricted wrist range of motion (median modified Mayo wrist score [MMWS] 17.5 [range 10–30]). Radiography revealed stages 1 to 3 disease (Herbert–Lanzetta classification). Median scapholunate angle was 62° (54°–75°), with 3 wrists suffering dorsal intercalated segment instability (DISI). Magnetic resonance imaging showed (Kalainov criteria) 4 stage 1 wrists (complete necrosis) and 4 stage 2 (incomplete necrosis). Two had concomitant Kienböck disease. All patients underwent nonsurgical treatment (ie, oral pain killer, immobilization, rest) and were monitored via radiographic and clinical evaluations. Scapholunate angles and the scaphoid area reduction ratio were calculated using radiography. Response criteria were the patients’ subjective and objective status. Endpoint was the time from start of non-surgical to surgical treatment.
Immobilization lasting 0 to 24 months (median 1.8 months) did not relieve their symptoms. Follow-up radiography showed that the disease stage had progressed in 5 of 8 wrists, with 5 wrists having DISI. The median area reduction ratio of the scaphoid was 11% (4%–52%) on anteroposterior views and 4% (−23% to 17%) on lateral views. Compared with the contralateral wrist, the median wrist flexion-extension arc was 61% (50%–79%) and the median grip strength 39%. Median MMWS score was 17.5 (10–25) – poor in 6 of 8 patients. Surgery was thus necessary in all patients.
Nonsurgical treatment for Preiser disease did not improve subjective or objective outcomes and did not prevent deterioration of radiographic findings.
Type of study/level of evidence: Therapeutic, Level V.
Comparisons of periventricular device closure, conventional surgical repair, and transcatheter device closure in patients with congenital ventricular septal defects
Authors: Li Dongxu , Zhang Zhao , Li Mengsi 
Published: January 2020

Abstract

Background:
Surgical treatments for ventricular septal defects (VSDs) mainly include 3 approaches: conventional surgical repair (CSR), transcatheter device closure (TDC), and perventricualr device closure (PDC). PDC has been introduced in over 10 years, although there remain concerns about adverse events. This network meta-analysis is to compare PDC, CSR, and TDC in the treatment of congenital VSD.

Methods:
We will search MEDLINE, EMBASE, Clinical Trials, Cochrane Library, and China National Knowledge Infrastructure databases for comparative studies on device closure and conventional repair for congenital VSDs to August 2019. A network meta-analysis with frequentist frame will be performed to compare the 3 approaches involving the success rate, in-hospital indexes, and incidences of complications, using risk ratio with 95% confidence intervals.

Results:
This study will be submitted to a peer-reviewed journal for publication.

Conclusion:
This network meta-analysis will assess the safety and efficacy of PDC, CSR, and TDC in the treatment of congenital VSDs, and provide more evidence-based guidance in clinical practice.

PROSPERO registration number:
CRD42019125257.
99mTc-DPD scintigraphy and SPECT/CT in patients with AL and ATTR type amyloidosis
Authors: Lee Joohee , Kim Kihyun , Choi Jin-Oh , Kim Seok Jin , Jeon Eun-Seok , Choi Joon Young 
Published: January 2020

Abstract
Although pathological confirmation is the gold standard for diagnosis of amyloidosis, there is a need for a relevant imaging modality to identify involved organs and evaluate disease extent. Thus, we prospectively investigated imaging findings of 99mTc-DPD scintigraphy in AL and ATTR amyloidosis.
A total of 21 subjects with pathologically confirmed AL or ATTR amyloidosis were included. Pretreatment whole body 99mTc-DPD planar scanning and regional SPECT/CT were performed in all subjects. For allegedly involved organs, 99mTc-DPD uptake was visually and semi-quantitatively evaluated on a 4-point scale (grade 0: no uptake, 1: uptake less than spine, 2: uptake similar to spine, and 3: uptake greater than spine).
There were 29 organs involved in AL and 12 in ATTR. Significant 99mTc-DPD uptake was found in 24 organs (sensitivity = 82.8%) in AL and 9 organs (sensitivity = 75.0%) in ATTR. Additional SPECT/CT was helpful to ensure abnormal DPD uptake in the involved organs, which was uncertain by attenuation in planar imaging. Degree of 99mTc-DPD uptake was significantly higher in ATTR compared with AL amyloidosis (P = .017). Diffuse soft tissue uptake with photon defects in the liver area was found only in ATTR amyloidosis.
This study showed that 99mTc-DPD scintigraphy might have capacity to differentiate between AL and ATTR subtypes with good sensitivity in various organs involving primary systemic AL and ATTR amyloidosis. Additional SPECT/CT significantly improved the diagnostic efficacy of 99mTc-DPD scintigraphy.
Feasibility of using two-dimensional axial computed tomography in pretreatment decision making for patients with early gastric cancer
Authors: Kim Duk Ki , Kang Sun Hyung , Kim Ju Seok , Rou Woo Sun , Joo Jong Seok , Kim Myung Hee , Eun Hyuk Soo , Moon Hee Seok , Lee Eaum Seok , Kim Seok Hyun , Sung Jae Kyu , Lee Byung Seok , Jeong Hyun Yong 
Published: January 2020

Abstract
Computed tomography (CT) is widely used in the pretreatment period of early gastric cancer (EGC). Only few studies have reported low accuracy of CT imaging for T and N staging in patients with EGC. However, owing to the limited number of studies, the value of CT imaging for EGC staging is not well known. Thus, we conducted a retrospective cross-sectional study regarding the associations among submucosal invasion, lymph node metastasis, and CT findings.
The medical records of patients with EGC who had surgery or endoscopic resection were reviewed in a single center from January 2011 to December 2016. We evaluated the histological type, invasion depth, and lymph node (LN) metastasis on the basis of two-dimensional CT findings.
We enrolled 1544 patients. Submucosal (SM) invasion was related to tumor size, histological type, and wall thickening or enhancement on CT images. Deep SM invasion (>500 μm) was also related to tumor size, poorly differentiated type, and abnormal CT findings (wall thickening, enhancement, and central depression). Among the patients with LN reactive positivity (0.5–1 cm), those who were female and had a tumor invasion of >1000 μm showed a higher prevalence of LN metastasis. The false-negative LN group had a higher prevalence of large tumors (>3 cm), poor differentiation, and SM invasion than the true-negative group.
Wall thickening, enhancement, and central depression on CT images might be related to SM invasion. Patients with any positive CT findings needs more attention when performing ESD
Acupoint catgut embedding for asthma in adults
Authors: Lu Xiaoxiao , Wu Xianming , Wu Xingrong , Chen Panbi , Cui Jin 
Published: January 2020

Abstract

Background:
Asthma exacerbations can do a lot of harm to the patients and consume large amounts of medical resources. Although some studies have evaluated acupuncture for asthma in children, few studies have estimated acupoint catgut embedding therapy. We aim to assess the efficacy and safety of acupoint catgut embedding for asthma in adults.

Methods:
The following databases will be searched from inception to December, 2019: Medline, Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, the China National Knowledge Infrastructure Database (CNKI), the Chinese Scientific Journal Database (VIP database), and the Wan-fang database. We will also search relevant conference abstracts, and registers of clinical trials. Two reviewers will independently undertake study selection, data extraction, and quality assessment. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. The Revman V5.3 software will be used to conduct meta-analysis.

Results:
The primary outcome was lung function, forced expiratory volume in one second and forced vital capacity (FVC) were the most commonly used parameters to evaluate lung function. The safety assessment includes the incidence of adverse events.

Conclusion:
This systematic review will retrieve clinical randomized controlled trials (RCT) on acupoint catgut embedding for asthma in 7 databases, aiming to describe and update existing evidence on the efficacy and safety of acupoint catgut embedding for asthma in adults.
PROSPERO registration number: CRD42019148401.
Robot-assisted direct repair of spondylolysis
Authors: Tian Wei , Zhang Qi , Han Xiao-Guang , Yuan Qiang , He Da , Liu Ya-Jun 
Published: January 2020

Abstract

Introduction:
Direct repair of the pars defect in lumbar spondylolysis is an effective surgical procedure, but it is technically challenging. We assessed the feasibility of a new robotic system for intralaminar screw fixation of spondylolysis.

Patient concerns:
A 26-year-old man complained about frequent low back pain after failed conservative treatments.

Diagnosis:
The lumbar computed tomography images demonstrated the presence of bilateral spondylolysis at the L5 level, with no spondylolisthesis.

Interventions:
We performed one surgery of direct intralaminar screw fixation under the guidance of the TiRobot system. The trajectory of the screw was planned based on intraoperative 3-dimensional radiographic images. Then, the robotic arm spontaneously moved to guide the guide wires and screw insertion.

Outcomes:
Bilateral L5 intralaminar screws were safely and accurately placed. No intraoperative complications occurred. Postoperative computed tomography showed good radiological results, without cortical perforation.

Conclusion:
We report the first case of robot-assisted direct intralaminar screw fixation for spondylolysis using the TiRobot system. Robotic guidance for direct repair of spondylolysis could be feasible.
Development and validation of a nomogram for predicting long-term overall survival in nasopharyngeal carcinoma
Authors: Wu Jiayuan , Zhou Quan , Pan Zhenyu , Wang Yufeng , Hu Liren , Chen Guanghua , Wang Shengpeng , Lyu Jun 
Published: January 2020

Abstract
We aimed to develop a nomogram based on a population-based cohort to estimate the individualized overall survival (OS) for patients with nasopharyngeal carcinoma (NPC) and compare its predictive value with that of the traditional staging system.
Data for 3693 patients with NPC were extracted from the Surveillance, Epidemiology, and End Results dataset and randomly divided into two sets: training (n = 2585) and validation (n = 1108). On the basis of multivariate Cox regression analysis, a nomogram was constructed to predict the 3-, 5-, and 10-year survival probability for a patient. The performance of the nomogram was quantified with respect to discrimination, calibration, and clinical utility.
In the training set, age, sex, race, marital status, histological type, T stage, N stage, M stage, radiotherapy, and chemotherapy were selected to develop a nomogram for predicting the OS probability based on the multivariate Cox regression model. The nomogram was generally more discriminative compared with the American Joint Committee on Cancer 7th staging system. Calibration plots exhibited an excellent consistency between the observed probability and the nomogram's prediction. Categorical net classification improvement and integrated discrimination improvement suggested that the predictive accuracy of the nomogram exceeded that of the classic staging system. With respect to decision curve analyses, the nomogram exhibited preferable net benefit gains than the staging system across a wide range of threshold probabilities.
This proposed nomogram exhibits an excellent performance with regard to its predictive accuracy, discrimination capability, and clinical utility, and thus can be used as a convenient and reliable tool for prognosis prediction in patients with NPC.
Carotid artery plaques and unilateral spatial neglect in the elderly
Authors: Wu Yixiao , Dai Yue , Jia Yanli , Yu Shuhang , Xu Siyuan , Wang Wei 
Published: January 2020

Abstract
The causes for falls in the elderly are varied, and visual spatial neglect could be 1 contributing factor. Further, the presence of a carotid artery plaque, especially on the right side, might influence the visual spatial attention of the elderly.
Our aim was to identify the intrinsic association between carotid plaques and lateralization of spatial attention in the elderly. Further, we sought to understand and potentially prevent the consequences of unilateral spatial neglect such as injury from falls.
Participants aged 64 to 93 years were divided into a group with carotid artery plaque(s) of the right side or both sides (BOTH, n = 38; and 9/ 38 were right side only) and a group without right-side carotid artery plaque(s) (LEFT, n = 53). Participants were asked to perform a line bisection task and undergo doppler ultrasonography examinations.
Contrary to expectations, compared to LEFT, the mean index and net scores of the line bisection errors in BOTH were significantly less leftward, but the mean diameter of the right-side common carotid artery in BOTH was significantly larger.
Our results indicate that the presence of carotid plaque(s) might be linked to increased risk of falls in the elderly. The attenuated spatial neglect in participants with right-side carotid artery plaque(s) might be due to compensatory carotid artery dilatation.
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer
Authors: Guo Weifeng , Zeng Huiqing , Zheng Jinyang , He Yueming , Zhuang Xibin , Cai Jinghuang , Huang Hong , Huang Hongbo , Xu Meng 
Published: January 2020

Abstract
The aim of this study was to investigate the expression of Kif18A in cancerous and paracancerous tissues from 100 patients with nonsmall cell lung cancer (NSCLC).
This was a prospective study of 100 patients with pathologically confirmed NSCLC (adenocarcinoma and squamous cell carcinoma [SCC], n = 50/group) that were operated at the Quanzhou First Hospital Affiliated to Fujian Medical University between June 2015 and December 2016. Kif18A protein expression in cancerous and paracancerous normal tissues was detected by western blot and immunohistochemistry.
The expression of the Kif18A protein was higher in adenocarcinoma and SCC tissues than in the corresponding paracancerous normal tissues. The expression of the Kif18A protein was higher in highly differentiated tumors, in patients with lymph node metastasis (vs no lymph node metastasis), adenocarcinoma, and in stage III NSCLC. There were no associations between Kif18A expression and age, gender, and pathologic type.
The expression of the Kif18A protein by immunohistochemistry was higher in NSCLC tissues than in normal tissues, and was associated with tumor differentiation, lymph node metastasis, and TNM staging. These results could provide a theoretical basis for novel molecular targeted therapies against NSCLC.
Textural analysis of hybrid DOTATOC-PET/MRI and its association with histological grading in patients with liver metastases from neuroendocrine tumors
Authors: Weber Manuel , Kessler Lukas , Schaarschmidt Benedikt , Fendler Wolfgang Peter , Lahner Harald , Antoch Gerald , Umutlu Lale , Herrmann Ken , Rischpler Christoph 
Published: January 2020

Aims
Neuroendocrine tumors (NETs) are known to overexpress somatostatin receptors (SSTR), which can be visualized by DOTATOC-PET. Reduced SSTR expression on the other hand may indicate dedifferentiation. The aim of this retrospective study was to assess, if conventional PET parameters and textural features (TF) derived from simultaneous PET and MRI including apparent diffusion coefficient (ADC) are associated with the proliferative activity of NETs, potentially allowing non-invasive tumor grading.

Methods
Our institutional database was screened for patients with NET and liver metastases >1 cm. We assessed conventional PET parameters, such as maximum and mean standardized uptake value and more elaborate TF parameters from PET and ADC-MRI (including entropy and homogeneity) from up to the five largest liver lesions per patient. The association of proliferative activity as measured by Ki67-/MIB1-index with the aforementioned parameters was analyzed.

Results
One hundred patients with NET/NECs were eligible with a Ki67-index ranging from <1% to 30%. Overall, 304 liver lesions were analyzed. Conventional PET parameters, entropy, homogeneity of PET and ADC maps differed significantly between G1 and G2 NETs. However, Spearman’s test showed a weak association (r = −0.23 to 0.31).

Discussion
In our study cohort, conventional PET parameters and TF of PET and ADC-MRI showed only a weak correlation with Ki67. This indicates that in patients with a Ki67-index of up to 30% TF analysis of combined PET/MRI may not be reliably used for accurate non-invasive tumor grading. On the other hand, DOTATOC-PET might be a suitable staging tool in some higher grade NET/NECs.
The significance of serum thyroglobulin measurement before and after the treatment of toxic nodular goiter with 131I
Authors: Bonefačić Boris , Crnčić Tatjana Bogović , Tomaš Maja Ilić , Girotto Neva , Ivanković Svjetlana Grbac 
Published: January 2020

Objectives
Thyroglobulin is routinely used as a tumor marker in follow up of patients with thyroid carcinoma, but is also elevated in patients with toxic nodular goiter. The aim of this study was to evaluate the role of thyroglobulin measurement prior to and after the radioiodine therapy (RIT) in patients with toxic nodular goiter and to compare the results with the therapy outcome.

Patients and methods
In 109 patients with toxic nodular goiter (102 females, 7 males, aged 45–85 years), 61 with multinodular toxic goiter and 48 with toxic adenoma, thyroglobulin level was measured before RIT and during the first 12 months after the treatment and compared to therapy outcome, defined as euthyroid, hypothyroid and persistent hyperthyroidism.

Results
In patients with euthyroid and hypothyroid outcome, a significant fall of thyroglobulin level was noted during the first 12 months after RIT, more prominent in the latter group. In patients with persistent hyperthyroidism, the initial thyroglobulin level was higher than in other two groups and no significant decrease was noted by the end of the first year after therapy, especially in patients with multinodular toxic goiter.

Conclusions
The significant fall of thyroglobulin after RIT observed in patients in whom euthyroidism and hypothyroidism was achieved indicates that thyroglobulin values can be related to the treatment outcome. In patients with high initial thyroglobulin levels (above 400 ng/l), and possible unfavorable RIT outcome, higher radioiodine activities or other treatment options might be considered.
Video abstract: http:/links.lww.com/NMC/A163
Eosinophilic Esophagitis Histology Remission Score
Authors: Collins Margaret H. , Martin Lisa J. , Wen Ting , Abonia Juan Pablo , Putnam Philip E. , Mukkada Vincent A. , Rothenberg Marc E. 
Published: January 2020

ABSTRACTObjectives:Eosinophilic esophagitis (EoE) is characterized by remissions and relapses. Guidelines defining remission do not exist and therefore remission is inconsistently identified. We sought to define histology remission in EoE.Methods:Esophageal biopsies, obtained at the time the validated pediatric EoE symptoms scores v2.0 (PEESS v2.0) questionnaire was completed (N = 42), were scored using the validated EoE Histology Scoring System. An EoE Histology Remission Score (EoEHRS) was constructed and specified that in all esophageal sites sampled the peak eosinophil count was <15 per high power field (HPF); in addition, neither the total grade (severity of pathology) nor stage (extent of pathology) scores could exceed 3 (possible total maximum score for each was 24). Spearman correlation coefficients were generated for histology/symptom correlations; coefficient range 0.31 to 0.50 was considered moderate.Results:EoE Histology Scoring System composite and individual feature scores from proximal and distal esophageal biopsies correlated moderately with PEESS v2.0 mean scores (0.48–0.36, P < 0.01), and with scores in the dysphagia (0.39–0.30, P ≤ 0.01), pain (0.48–0.34, P ≤ 0.01), and gastroesophageal reflux disease (0.51–0.32, P ≤ 0.01) domains. Biopsies that met full EoEHRS criteria had reduced biomarkers, specifically expression of the mast cell markers CPA3 and tryptase mRNA, and reduced eosinophil peroxidase deposition (P < 0.03), compared to those with nonremission scores. Subjects whose biopsies met EoEHRS remission criteria reported reduced symptoms for all domains except nausea and vomiting (P ≤ 0.01).Conclusions:The EoEHRS correlated with reduced biomarkers of disease activity and reduced symptoms, and therefore may be useful to inform clinical care and interstudy comparisons.