bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in poor self‐rated health status among elderly Koreans over 10 years: Community Health Survey 2008–2017
Authors: Jung Jin‐Gyu , Yoon Seok‐Joon , Ahn Soon‐Ki , Kim Jong‐Sung , Nam Hae‐Sung , Ku Bon Jeong , Kim Ho , Kwon In‐Sun 
Published: October 2020

AimThis study investigated the change in self‐rated health (SRH) status among elderly Koreans and sought influential factors affecting SRH by reference to data collected during the Korean Community Health Survey 2008–2017.MethodsWe obtained raw data from the Korea Community Health Survey for 10 years (2008–2017), which included sociodemographic and health information on Koreans aged ≥65 years (242 552 men and 349 586 women). SRH was measured using the SRH scale and divided into not‐poor and poor. Logistic regression analyses of poor SRH were performed using a weighted sampling method and interaction models (year × variables) to represent the entire Korean elderly population and estimate the changes in poor SRH over time.ResultsThe proportion of elderly subjects in the population increased over 10 years. After adjusting for all confounding variables, the weighted adjusted odds ratios for poor SRH decreased consistently between 2008 and 2017 (men: 0.64, 95% confidence interval 0.50–0.81; women: 0.62, 0.46–0.83). The odds ratios for poor SRH were markedly higher in subjects who reported being stressed (men: 7.02, 5.89–8.38; women 6.14, 5.33–7.08) and those who lacked formal education (men: 2.42, 2.18–2.69; women 3.12, 2.59–3.75) over times.ConclusionsDespite the increase in the proportion of the elderly, poor SRH among elderly Koreans decreased over the past 10 years. Poor SRH was associated with high‐level perceived stress and a lower educational level in both elderly men and women. Geriatr Gerontol Int 2020; 20: 1190–1195.
In situ graphitization role on oxidation resistance and physicomechanical properties of resin‐bonded Al2O3‐MgO castables
Authors: Talabi Segun I. , Luz Ana P. , Lucas Alessandra A. 
Published: October 2020

AbstractThe properties of carbon‐containing refractories (CCRs) depend on the presence of carbon with features close to graphite. However, the thermosetting resins that are used to bind such refractories together during the initial preparation stage usually produce non‐graphitic carbon when sintered, which can impair their overall performance. Based on this, ferrocene was used to induce graphitic carbon generation from a resole‐type phenolic resin during a sequential carbonization operation. The resin formulation containing the graphitizing agent was then used to prepare resin‐bonded Al2O3‐MgO castables. The role of in situ graphitization of the modified binder on the properties such as cold crushing strength, apparent porosity, and oxidation resistance was examined. The results show that crystallization of the binder carbon can improve the castable oxidation resistance. At ambient temperature, no significant difference was observed in the samples' physicomechanical properties. Nevertheless, holding time during the initial curing stage at 50°C played a significant role on those properties.
‘Don’t abandon me’: Young people’s experiences of child and adolescent psychiatric inpatient care supporting recovery described in blogs
Authors: Wallström Rebecca , Lindgren Eva , Gabrielsson Sebastian 
Published: October 2020

AbstractChild and adolescent psychiatric (CAP) inpatient care has the potential to support or hinder young people’s mental‐health recovery. Research describing inpatient care from the perspective of young people is rare. Personal blogs provide an opportunity to further understand how inpatient care relates to young people’s recovery processes. This study aimed to explore young people’s experiences of CAP inpatient care supporting mental‐health recovery. The study is reported in accordance with the COREQ guidelines. Data were created during 2018 from twenty‐seven personal blogs describing first‐hand experiences of being a patient in a CAP inpatient care facility in Sweden and analysed using a method for interpretive description. Information in blogs suggests they were written by women, a majority of which had experienced eating disorders. Findings describe young people’s experiences of CAP inpatient care supporting mental‐health recovery in an interpretive explanation with one theme, ‘Don’t abandon me’, and three sub‐themes: ‘Listen to me’, ‘Believe in me’, and ‘Allow me to feel safe’. This study adds to the growing body of empirical work suggesting the importance of the concept of recovery in young people’s mental health. To support recovery, CAP inpatient care needs to focus on developing the content of care rather than minimizing the length of the stay. User experience should be at the heart of efforts aimed at improving services.
Hospital staff well‐being during the first wave of COVID‐19: Staff perspectives
Authors: Digby Robin , Winton‐Brown Toby , Finlayson Felicity , Dobson Hannah , Bucknall Tracey 
Published: October 2020

AbstractThe purpose of this research is to determine the impact of working during the early stage of the COVID‐19 pandemic on the well‐being of staff at one 600‐bed acute hospital in metropolitan Melbourne, Australia. This exploratory study is part of a larger mixed methods survey project, reporting the qualitative data from an on‐line survey of clinical staff working at one acute hospital between April 16th and May 13th, 2020 during the COVID‐19 pandemic. Responses to five free‐text questions were analysed using inductive content analysis. 321 medical, nursing, allied health and non‐clinical staff responded to the survey. Respondents reported anxiety, fear and uncertainty related to the pandemic, from the perspectives of work, home, family and community. They reported feeling confused by inconsistent messages received from government, hospital executive, managers and media. Seven themes were identified: (i) worrying about patient care, (ii) changed working conditions, (iii) working in the changed hospital environment, (iv) impact of the pandemic, (v) personal isolation and uncertainty, (vi) leadership and management and (vii) additional support needed for staff. Despite the pandemic being comparatively well‐controlled in Australia, all disciplines reported a high degree of anticipatory anxiety. Staff working in healthcare require both managerial and psychological support to minimise anxiety and promote well‐being and resilience in order to deal with the health crisis. Regular unambiguous communication directing the way forward is crucial.
Patient participation in forensic psychiatric care: Mental health professionals' perspective
Authors: Selvin Mikael , Almqvist Kjerstin , Kjellin Lars , Schröder Agneta 
Published: October 2020

AbstractPatient participation is a central concept in modern health care and an important factor in theories/models such as person‐centred care, shared decision‐making, human rights approaches, and recovery‐oriented practice. Forensic psychiatric care involves the treatment of patients with serious mental illnesses who also have committed a crime, and there are known challenges for mental health staff to create a health‐promoting climate. The aim of the present study was to describe mental health professionals' perceptions of the concept of patient participation in forensic psychiatric care. Interviews were conducted with 19 professionals and were analysed with a phenomenographic approach. The findings are presented as three descriptive categories comprising five conceptions in an hierarchic order: 1. create prerequisites – to have good communication and to involve the patient, 2. adapt to forensic psychiatric care conditions – to take professional responsibility and to assess the patient’s current ability, and 3. progress – to encourage the patient to become more independent. The findings highlight the need for professionals to create prerequisites for patient participation through good communication and involving the patient, whilst adapting to forensic psychiatric care conditions by taking professional responsibility, assessing the patient’s ability, and encouraging the patient to become more independent without adding any risks to the care process. By creating such prerequisites adapted to the forensic psychiatric care, it is more likely that the patients will participate in their care and take more own responsibility for it, which also may be helpful in the patient recovery process.
Protectin DX promotes epithelial injury repair and inhibits fibroproliferation partly via ALX/PI3K signalling pathway
Authors: Yang Jing‐Xiang , Li Ming , Hu Xin , Lu Jia‐Chao , Wang Qian , Lu Shi‐Yue , Gao Fang , Jin Sheng‐Wei , Zheng Sheng‐Xing 
Published: October 2020

AbstractAcute respiratory distress syndrome/acute lung injury (ARDS/ALI) is histologically characterized by extensive alveolar barrier disruption and excessive fibroproliferation responses. Protectin DX (PDX) displays anti‐inflammatory and potent inflammation pro‐resolving actions. We sought to investigate whether PDX attenuates LPS (lipopolysaccharide)‐induced lung injury via modulating epithelial cell injury repair, apoptosis and fibroblasts activation. In vivo, PDX was administered intraperitoneally (IP) with 200 ng/per mouse after intratracheal injection of LPS, which remarkedly stimulated proliferation of type II alveolar epithelial cells (AT II cells), reduced the apoptosis of AT II cells, which attenuated lung injury induced by LPS. Moreover, primary type II alveolar cells were isolated and cultured to assess the effects of PDX on wound repair, apoptosis, proliferation and transdifferentiation in vitro. We also investigated the effects of PDX on primary rat lung fibroblast proliferation and myofibroblast differentiation. Our result suggests PDX promotes primary AT II cells wound closure by inducing the proliferation of AT II cells and reducing the apoptosis of AT II cells induced by LPS, and promotes AT II cells transdifferentiation. Furthermore, PDX inhibits transforming growth factor‐β1 (TGF‐β1) induced fibroproliferation, fibroblast collagen production and myofibroblast transformation. Furthermore, the effects of PDX on epithelial wound healing and proliferation, fibroblast proliferation and activation partly via the ALX/ PI3K signalling pathway. These data present identify a new mechanism of PDX which targets the airway epithelial cell and fibroproliferation are potential for treatment of ARDS/ALI.
Activation of LncRNA FOXD2‐AS1 by H3K27 acetylation regulates VEGF‐A expression by sponging miR‐205‐5p in recurrent pterygium
Authors: Gao Yali , Luo Xiaoling , Zhang Jun 
Published: October 2020

AbstractLncRNA FOXD2‐AS1 is abnormally expressed in many diseases. However, the molecular mechanisms whereby FOXD2‐AS1 is involved in recurrent pterygium remain unknown. Here, qRT‐PCR was performed to quantify FOXD2‐AS1 expression, while CCK‐8, flow cytometer and neoplasm xenograft assays were used to investigate its function. Dual‐luciferase reporter, RIP and RNA pull‐down assays were conducted to address the relationship between FOXD2‐AS1, miR‐205‐5p and VEGF‐A, while ChIP assays were used to detect H3K27 acetylation at the FOXD2‐AS1 promoter. FOXD2‐AS1 expression was up‐regulated in recurrent pterygium tissues. Moreover, a high FOXD2‐AS1 expression was associated with advanced stages, increased microvessel density and shorter recurrent‐free survival. In addition, ROC analysis showed that FOXD2‐AS1 is a valid predictor of recurrent pterygium. Furthermore, we show that FOXD2‐AS1 induced proliferation and inhibited apoptosis in a cell line derived from recurrent pterygia (HPF‐R) at least partially through the regulation of the miR‐205‐VEGF pathway. In addition, the up‐regulation of FOXD2‐AS1 was attributed to the H3K27 acetylation at the promoter region. In conclusion, FOXD2‐AS1 is activated via its H3K27 acetylation and regulates VEGF‐A expression by sponging miR‐205‐5p in recurrent pterygium. Our results may provide a basis for the development of new therapeutic targets and biomarkers for recurrent pterygium.
Glucose effectiveness: Lessons from studies on insulin‐independent glucose clearance in mice
Authors: Ahrén Bo , Pacini Giovanni 
Published: October 2020

AbstractBesides insulin‐mediated transport of glucose into the cells, an important role is also played by the non‐insulin‐mediated transport. This latter process is called glucose effectiveness (acronym SG), which is estimated by modeling of glucose and insulin data after an intravenous glucose administration, and accounts for ≈70% of glucose disposal. This review summarizes studies on SG, mainly in humans and rodents with focus on results achieved in model experiments in mice. In humans, SG is reduced in type 2 diabetes, in obesity, in liver cirrhosis and in some elderly populations. In model experiments in mice, SG is independent from glucose levels, but increases when insulin secretion is stimulated, such as after administration of the incretin hormones, glucagon‐like peptide‐1 and glucose‐dependent insulinotropic polypeptide. SG is reduced in insulin resistance induced by high‐fat feeding and by exogenous administration of glucagon. Glucose‐dependent (insulin‐independent) glucose disposal is therefore important for glucose elimination, and it is also well regulated. It might be of pathophysiological relevance for the development of type 2 diabetes, in particular during insulin resistance, and might also be a target for glucose‐reducing therapy. Measuring SG is essentially important when carrying out metabolic studies to understand glucose homeostasis.
Impact of daily glucose fluctuations on cardiovascular outcomes after percutaneous coronary intervention for patients with stable coronary artery disease undergoing lipid‐lowering therapy
Authors: Yamamoto Hiroyuki , Shinke Toshiro , Otake Hiromasa , Kawamori Hiroyuki , Toba Takayoshi , Kuroda Masaru , Hirota Yushi , Sakaguchi Kazuhiko , Ogawa Wataru , Hirata Ken‐ichi 
Published: October 2020

AbstractAims/IntroductionGlucose fluctuation (GF) is a residual risk factor for coronary artery disease (CAD). We investigated whether GF influenced clinical outcomes and progression of coronary stenosis in stable CAD patients.Materials and MethodsIn this prospective study, 101 consecutive lipid‐controlled stable CAD patients underwent percutaneous coronary intervention were enrolled, and GF was expressed as the mean amplitude of glycemic excursion (MAGE) obtained by continuous glucose monitoring before the procedure was evaluated. At 9 months after enrollment, culprit and non‐culprit (mild‐to‐moderate stenosis without ischemia) lesions were serially assessed by angiography. Cardiovascular events (CVE) consisting of cardiovascular death, non‐fatal myocardial infarction or ischemia‐driven revascularization during 2‐year follow up, rapid progression in non‐culprit lesions (defined as ≥10% luminal narrowing progression in lesions with stenosis ≥50%, ≥30% luminal narrowing progression in non‐culprit lesions with stenosis <50% or normal segment, or progression to total occlusion) were evaluated.ResultsCVE occurred in 25 patients, and MAGE was significantly higher in the CVE group (76.1 ± 24.8 mg/dL vs 59.3 ± 23.7 mg/dL; P = 0.003). Multivariate analysis showed that MAGE was an independent predictor of CVE (odds ratio 1.027, 95% confidence interval 1.008–1.047; P = 0.005). The optimal MAGE value to predict CVE was 70.7 mg/dL (area under the curve 0.687, 95% confidence interval 0.572–0.802; P = 0.005). Furthermore, MAGE was independently associated with rapid progression, and with the luminal narrowing progression in all non‐culprit lesions (r = 0.400, P < 0.05).ConclusionsDaily GF might influence future CVE in lipid‐controlled stable CAD patients.
Young people with type 1 diabetes on insulin pump therapy could fast safely during COVID–19 pandemic Ramadan: A telemonitoring experience in Bangladesh
Authors: Zabeen Bedowra , Ahmed Bulbul , Nahar Jebun 
Published: October 2020

AbstractOur aim was to report our telemedicine experience with type 1 diabetes patients using insulin pumps who fasted for Ramadan 2020 during the COVID‐19 pandemic. The routine diabetes outpatient care in our Changing Diabetes in Children (CDiC) Pediatric Diabetes Center at the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders hospital was closed, as there was a lockdown from 26 March in Bangladesh. The diabetes team in our center started telemedicine care for routine follow up of patients. Nine patients who wished to fast for Ramadan contacted our diabetes team over the phone. The mean age was 19.3 ± 5.0 years, and five (55.6%) were female. Most of the patients fasted >20 days. Hyperglycemia and mild hypoglycemia were common complications during fasting. There was no episode of severe hypoglycemia or diabetic ketoacidosis, and none of the patients required admission. During the COVID‐19 crisis in Bangladesh, patients with type 1 diabetes using an insulin pump could fast safely for Ramadan with the support of the telemedicine service by the diabetes team.
Reactive granulomatous dermatitis as a histological pattern including manifestations of interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis: a study of 52 patients
Authors: Rodríguez‐Garijo N. , Bielsa I. , Mascaró J.M. , Quer A. , Idoate M.A. , Paricio J.J. , Iranzo P. , España A. 
Published: October 2020

AbstractBackgroundConfusion exists regarding interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic and granulomatous dermatitis (PNGD).ObjectiveTo determine whether IGD and PNGD are two different entities, or whether they must be considered as two subtypes of the same reactive pattern, and thus whether the unification of the nomenclature is necessary.MethodsObservational retrospective multicentre study of patients with IGD and PNGD evaluated between 1999 and 2019 and review of their clinical and histological features.ResultsWe identified 52 patients (38 women and 14 men). Clinical and histological findings of IGD were observed in 88.4% of cases. The most common cutaneous lesions were plaques/macules (IGD) or annular plaques and papules/nodules (PNGD), located mostly on the limbs and trunk. The rope sign was developed in two patients with IGD that associated autoimmune disorders. Similar associated comorbidities (75%) were found in both entities, mainly autoimmune diseases (53.8%). In IGD, the infiltrate was predominantly lympho‐histiocytic. Neutrophilic infiltrates, karyorrhexis and skin lesions with limited clinical course were mainly associated with PNGD biopsies. In biopsies with a limited recurrent course, a predominant lymphocytic inflammatory infiltrate was found. Collagen degeneration was present in 75.9% of cases. The floating sign was observed only in IGD type patients (63%). Overlapping histological findings were found in one fourth of cases, especially between IGD and interstitial granuloma annulare. Interface dermatitis, apparently unrelated to drug intake, was observed in 4 cases of IGD.ConclusionWe support the term reactive granulomatous dermatitis to unify both the clinical and histological findings of IGD and PNGD, and the overlapping between IGD and interstitial granuloma annulare. According to this, a spectrum of histological changes will be found depending on the clinical course of the skin lesions.
Patients with bullous pemphigoid and comorbid psoriasis present with less blisters and lower serum levels of anti‐BP180 autoantibodies
Authors: Ständer S. , Schmidt E. , Zillikens D. , Thaçi D. , Ludwig R.J. , Kridin K. 
Published: October 2020

AbstractBackgroundAlthough the association of bullous pemphigoid (BP) and psoriasis is well‐established, the clinical and immunological features of patients with coexisting BP and psoriasis are yet to be investigated.ObjectiveWe aimed to estimate the prevalence of psoriasis amongst patients with BP and to elucidate the clinical and immunological characteristics of BP patients with comorbid psoriasis.MethodsA retrospective cohort study including all consecutive patients diagnosed with BP throughout the years 2009–2019 in a tertiary referral centre.ResultsThe study encompassed 273 patients with BP, of whom 11 (4.0%; 95% CI, 2.3–7.1%) had comorbid psoriasis. The onset of psoriasis preceded that of BP in 81.8% of patients by a median (range) latency of 26.5 (5.0–34.0) years. Compared to BP patients without psoriasis, those with BP and comorbid psoriasis were significantly younger at the onset of BP [71.8 (9.3) vs. 79.4 (9.8) years; P = 0.023], had a milder erosive phenotype [erosion/blister BPDAI mean (SD)score; 5 (4.1) vs. 22.3 (15.2); P = 0.025], lower levels of anti‐BP180 NC16A serum autoantibodies [236.6 (266.3) vs. 556.2 (1323.6) U/mL; P = 0.008] and a higher prevalence of isolated linear C3 deposits (36.4% vs. 14.1%; P = 0.043) and a lower prevalence of linear immunoglobulin G deposits (36.4% vs. 68.7%; P = 0.025) along the dermal–epidermal junction by direct immunofluorescence microscopy.ConclusionsPatients with BP and comorbid psoriasis present at a younger age with milder erosive phenotype and lower levels of pathogenic autoantibodies.
Evaluation of structural coloration of experimental flowable resin composites
Authors: Arai Yuiko , Kurokawa Hiroyasu , Takamizawa Toshiki , Tsujimoto Akimasa , Saegusa Makoto , Yokoyama Munenori , Miyazaki Masashi 
Published: October 2020

AbstractObjectiveTo examine the effect of filler contentTo examine the effect of filler content on structural coloration of experimental flowable resin composites.OverviewExperimental composites containing spherical fillers and different filler contents (30, 40, 50, 60 and 70 wt%), a structural colored resin composite (Omnichroma), and a nanohybrid flowable resin composite (Gracefil LoFlo) were used. The optical characteristics of the specimens were measured on standard black and white backgrounds using a spectrophotometer under CIE D65 illuminant and the L*a*b* values were determined. The color matching abilities to artificial teeth were evaluated using the ΔE*ab and ΔE00 color difference formulas. One‐way analysis of variance and Tukey's post hoc test were used. The spectral reflectance of experimental composites showed different trends in different backgrounds, plate thickness, and filler contents. In particular, higher spectral reflectance was observed on the white background at wavelengths ranging from 450 to 700 nm in both 1.5 and 3.0 mm plates when compared to the black background. The percent reflectivity tended to decrease with a decrease of the filler contents. The color matching abilities of the experimental composites improved with the increase in the filler contents.ConclusionsStructural coloration of the flowable resin composites were affected by the filler contents.Clinical significanceClinical Significance: Higher filler contents might be needed to achieve the optimal color properties of structural colored flowable resin composites, thereby improving the restoration esthetics.