bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I/II study of neoadjuvant carboplatin, eribulin mesylate, and trastuzumab (ECH) for operable HER2 positive (HER2+) breast cancer.
Authors: Schwartzberg Lee Steven , Tauer Kurt W. , Hermann Robert C. , Nikolinakos Petros G. , Houts Arthur C. 
Published: March 2020

TPS659 Background: Carboplatin, docetaxel and trastuzumab (TCH) regimen yields substantial pathologic complete response (pCR) in operable HER2+ breast cancer. Eribulin mesylate (E) is a tubulin inhibitor recently shown to improve overall survival compared to taxanes and other agents in heavily pretreated metastatic breast cancer patients. This trial was designed to determine the maximum tolerated dose (MTD) of E in combination with CH (Phase I) and to determine efficacy and safety of the ECH regimen (Phase II) given as neoadjuvant therapy to early stage HER2+ breast cancer with pathologic complete response the primary endpoint. Methods: This is a multicenter prospective open label single arm trial. Eligible patients were operable stage IIA – IIIB HER2+ breast cancer, ECOG 0-1, normal LVEF, QTc < 480 msec, < grade 1 neuropathy and no history of invasive cancer within the past 3 years. Phase I planned up to 12 patients from 4 centers to 1 of 3 E dose cohorts, with pts treated at the MTD also evaluable for Phase II. Starting dose level 0 was 1.1 mg/m2 with escalation to dose level +1 at 1.4 mg/m2 and de-escalation to dose level -1 at 0.9 mg/m2 if necessary. ECH was given IV for six 3-week cycles with E d1 and d8; C AUC 6 d1; and H 8 mg/kg loading dose d1C1 and 6 mg/kg d1C2-C6. H is scheduled to continue after surgery to complete 1 year of treatment. C1 dose limiting toxicities (DLTs) were defined as: grade 4 thrombocytopenia, anemia, or neutropenia lasting > 5 days; any grade 3-4 non-hematologic toxicity attributable to E, C, H, or the combination; inability to deliver all three agents at assigned dose and schedule. Standard 3+3 dose escalation design was used. At present, 6 patients have been enrolled at dose 0 and 6 have been enrolled at dose +1. The MTD for E has not yet been determined. Phase II has planned enrollment of 44 additional patients from 8 centers with primary endpoint rate of pCR at surgery to be performed 4-8 weeks after completion of ECH and secondary endpoints of safety to include peripheral neuropathy and cardiac toxicity at treatment completion and 1 year follow up. Clinical trial information: NCT101388647.
A phase III comparative study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus docetaxel in patients with previously treated advanced or metastatic squamous cell non-small cell lung cancer (NSCLC).
Authors: Borghaei Hossein , Lynch Thomas James , Rizvi Naiyer A. , Chow Laura Quan Man , Reilly Robert , Crinò Lucio , Buyse Marc E. , Ezzeddine Rana , Lestini Brian Joseph , Brahmer Julie R. 
Published: March 2020

TPS8122 Background: NSCLC is the leading cause of cancer death worldwide, exceeding breast, colon and prostate cancer combined. Most patients (pts) are diagnosed with advanced/recurrent disease. NSCLC therapies have incrementally improved overall survival (OS), but benefit has reached a plateau (median OS for late stage pts is just 1 yr). Squamous cell carcinoma (SCC) represents one quarter of NSCLC cases and has limited treatment options. Pemetrexed and bevacizumab are not approved in SCC, and molecularly targeted therapies have limited application. Single-agent chemotherapy is standard of care following progression with platinum-based doublet chemotherapy (Pt-doublet), resulting in median OS of approximately 7 months. Immune checkpoint blockade in NSCLC may promote tumor regression by reversing tumor-induced immunosuppression and restoring the antitumor immune response. Programmed death-1 (PD-1), an immune checkpoint receptor that negatively regulates T-cell activation, is upregulated in tumor infiltrating lymphocytes; expression of its ligand PD-L1 has been associated with poor prognosis in NSCLC. Nivolumab, a PD-1 receptor blocking antibody, showed encouraging antitumor activity in SCC pts in a phase 1 study, with objective responses (ORs) in 4 pts (27%) and stable disease ≥24 weeks in 1 pt (7%) (3 mg/kg; n=15) (Gettinger S et al; ESMO 2012 [Abstr 1237PD]). We describe an ongoing open-label phase 3 study to compare the clinical benefit of nivolumab vs docetaxel in advanced/metastatic SCC pts following failure of Pt-doublet. Methods: A total of 264 pts will be randomized 1:1 to nivolumab monotherapy 3 mg/kg IV every 2 weeks or docetaxel 75 mg/m2 every 3 weeks until disease progression or unacceptable toxicity. Pts will be stratified by prior paclitaxel use and geographic region. Tumor response will be assessed using modified RECIST 1.1. The co-primary objectives are OR rate and OS. Secondary objectives include progression free survival, clinical benefit in PD ligand 1 (PD-L1+) and PD-L1– subgroups (archived tissue required for entry), durability of and time to OR, and pt proportion with symptom improvement. Clinical trial information: NCT01642004.
Phase III study of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (A+AVD) versus doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) as front-line treatment for advanced classical Hodgkin lymphoma (HL).
Authors: Younes Anas , Radford John , Ansell Stephen Maxted , Gallamini Andrea , Kim Won Seog , Feldman Tatyana A. , Hamadani Mehdi , Chung Jeanenne , Wang Jingyuan , Huebner Dirk , Connors Joseph M. 
Published: March 2020

TPS8612 Background: Brentuximab vedotin, a CD30-targeted antibody-drug conjugate, has conditional approval in Europe for relapsed/refractory (RR) CD30-positive HL following autologous stem cell transplant (ASCT) or following ≥2 prior therapies when ASCT or multi-agent chemotherapy is not a treatment option. ABVD, a common front-line regimen for advanced HL, achieves complete response (CR) rates of 70–80%. However, 10–20% of patients (pts) are refractory to front-line treatment and up to 35% relapse after front-line multi-modality therapy. In pts with relapsed HL post-ASCT, single-agent brentuximab vedotin yields an objective response rate of 75% (CR, 33%; Chen ASH 2012). In a phase 1 study in treatment-naïve HL pts, A+AVD was associated with manageable toxicity and a CR rate of 96%; brentuximab vedotin + ABVD was contraindicated due to pulmonary toxicity (Ansell ASH 2012). We hypothesized that substituting bleomycin with brentuximab vedotin would eliminate bleomycin-associated pulmonary toxicity and improve progression-free survival (PFS) compared to a standard ABVD regimen. Methods: This ongoing, open-label, randomized, multicenter study (NCT01712490) will compare A+AVD vs ABVD in 1040 pts with stage III/IV classical HL. Primary endpoint: modified (m) PFS (death, progression, and receipt of chemotherapy or radiotherapy by pts not in CR after completing A+AVD or ABVD will count as progression event). Key secondary endpoint: overall survival. Key inclusion criteria: histologically-confirmed previously untreated stage III/IV classical HL. Pts will be stratified by region and International Prognostic Score, and will be randomized 1:1 to receive A+AVD (brentuximab vedotin 1.2 mg/kg with each dose of AVD) or ABVD administered intravenously on Days 1 and 15 of 28-day cycles, for up to 6 cycles. Disease status and survival will be evaluated regularly until study closure. Safety assessments: incidence and severity of adverse events, changes to physical and laboratory tests. Clinical trial information: NCT01712490.
Η συμβολή των νέων τεχνολογιών στην εκπαίδευση των ατόμων με αναπηρία και τη διαμόρφωση της αυτοεικόνας τους
Authors: Τερζοπούλου Θεοδώρα 
Published: March 2020

Στη σύγχρονη εποχή, οι νέες τεχνολογίες παρουσιάζουν ραγδαία ανάπτυξη και συμβάλλουν θετικά σε πολλούς τομείς δραστηριοποίησης των πολιτών. Πιο συγκεκριμένα όμως, φαίνεται ότι σε μεγάλο βαθμό ενθαρρύνουν την ομαλή εκπαίδευση των ατόμων με αναπηρία, εφόσον προωθούν την εναλλακτική μαθησιακή διαδικασία.Ο σκοπός της έρευνας ήταν να αναδείξει τους τρόπους με τους οποίους η τεχνολογία επιδρά στην αποτελεσματική μάθηση και την εκπαίδευση των ατόμων με αναπηρία, όπως και να μελετήσει τις συνέπειες της επίδρασης αυτής στην ανάπτυξη της αυτοεικόνας τους σε σχέση με τον τρόπο που αντιμετωπίζονται από τους φορείς της εκπαίδευσης.Η μέθοδος της έρευνας που διεξήχθη ήταν ποσοτική, καθώς το δείγμα που αποτέλεσαν μαθητές που φοιτούν στην πρωτοβάθμια και δευτεροβάθμια εκπαίδευση, κλήθηκε να απαντήσει σε ερωτηματολόγια τα οποία ήταν προσανατολισμένα στον σκοπό της έρευνας. Τα ευρήματα ανέδειξαν κυρίαρχες μορφές νέων τεχνολογιών που εφαρμόζονται κατά τη διδασκαλία στις βαθμίδες που αναφέρθηκαν, όπως και τους τρόπους με τους οποίους επηρεάζουν την αποτελεσματικότητα της μάθησης. Επιπλέον, φανερώθηκαν προσωπικές αντιλήψεις των μαθητών και πεποιθήσεις που σχετίστηκαν με την εικόνα της διαχείρισης της αναπηρίας τους μέσω της χρήσης των νέων τεχνολογιών.Τα αποτελέσματα της έρευνας, έκαναν γνωστή την συμβολή των νέων τεχνολογιών στην ουσιαστική εκπαίδευση των μαθητών/μαθητριών με αναπηρία και ανέδειξαν τη σημαντικότητα στην διαμόρφωση της αυτοεκτίμησής τους, γεγονός που είναι ικανό να θέσει τα ίδια άτομα προς κινητοποίηση για συνέχιση της εκπαιδευτικής τους πορείας.
Geotecnologias aplicadas na análise do risco de contaminação de poços de água no município de Sorocaba, SP
Authors: Nery Liliane Moreira , Simonetti Vanessa Cezar , Machado Levi Pompermayer , Silva Darllan Collins da Cunha e 
Published: March 2020

Em decorrência do crescimento da cidade de Sorocaba e da quantidade de empresas que se instalam todos os anos no município, o presente estudo teve como objetivo avaliar os riscos de contaminação dos poços de água próximos a áreas contaminadas utilizando técnicas de geoprocessamento. Para o levantamento das áreas contaminadas foi utilizado o inventário disponibilizado pela Companhia Ambiental do Estado de São Paulo (CETESB), e a localização dos poços outorgados do município foram obtidos através da base de dados do Departamento de Águas e Energia Elétrica (DAEE). A concentração de áreas contaminadas foi avaliada por meio do estimador de densidade de Kernel, e os valores foram ordenados em três diferentes classes de riscos de contaminação, sendo baixo, médio e alto. Os resultados demonstraram que 17,3% das áreas contaminadas estão inseridas na zona de alto risco, enquanto as zonas de risco médio obtiveram 50,0% dos pontos de contaminação. As zonas de alto e médio risco contemplam 57 poços de água, apresentando riscos de contaminação eminentes, podendo comprometer a saúde humana a partir do consumo e uso da água destes poços. A utilização de ferramentas de geoprocessamento na análise de riscos de contaminação mostrou-se eficaz, permitindo a seleção de zonas prioritárias para a gestão e monitoramento de poços de água.
Safety, advocacy, and the teacher’s role: Pre-service teachers and school shooting policies
Authors: Hara May 
Published: March 2020

In this qualitative case study, I examine pre-service teachers’ experiences with school shooting policy. Analysis of individual interviews, group discussions and reflective memos with pre-service teachers (n=7) in seven Massachusetts districts shows that pre-service teachers, while deeply concerned about the possibility of school shootings, viewed existing policies as ineffective, damaging to their pedagogical practice and relationships with students, and out of step with teachers’ concerns. Further, they interpreted proposed policies as undermining the value of teachers in contemporary society and threatening the core tenets of teachers’ work. Constrained by limited professional development around policy involvement, pre-service teachers expressed significant doubts about their ability to effect meaningful policy change. This research has implications for educational policy and teacher policy involvement.
Personal insights for altering decisions of tree-based ensembles over time
Authors: Boer Naama , Deutch Daniel , Frost Nave , Milo Tova 
Published: March 2020

Machine Learning models are prevalent in critical human-related decision making, such as resume filtering and loan applications. Refused individuals naturally ask what could change the decision, should they reapply. This question is hard for the model owner to answer: first, the model is typically complex and not easily interpretable; second, models may be updated periodically; and last, attributes of the individual seeking approval are apt to change in time. While each of these challenges have been extensively studied in isolation, their conjunction has not.
To this end, we propose a novel framework that allows users to devise a plan of action to individuals in presence of Machine Learning classification, where both the ML model and the user properties are expected to change over time. Our technical solution is currently confined to a particular yet important class of models, namely those of tree-based ensembles (Random Forests, Gradient Boosted trees). In this setting it uniquely combines state-of-the-art solutions for single model interpretation, domain adaptation techniques for predicting future models, and constraint databases to represent and query the space of possible actions. We devise efficient algorithms that leverage these foundations in a novel solution, and experimentally show that they are effective in proposing useful and actionable steps leading to the desired classification.
Evaluating memory-hard proof-of-work algorithms on three processors
Authors: Feng Zonghao , Luo Qiong 
Published: March 2020

Most public blockchain systems, exemplified by cryptocurrencies such as Ethereum and Monero, use memory-hard proof-of-work (PoW) algorithms in consensus protocols to maintain fair participation without a trusted third party. The memory hardness, or the amount of memory access, of these PoW algorithms is to prevent the dominance of custom-made hardware of massive computation units, in particular, application-specific integrated circuit (ASIC) and field-programmable gate array (FPGA) machines, in the system. However, it is unclear how effective these algorithms are on general-purpose processors.
In this paper, we study the performance of representative memory-hard PoW algorithms on the CPU, the Graphics Processing Unit (GPU), and the Intel Knights Landing (KNL) processors. We first optimize each algorithm for individual processors, and then measure their performance with number of threads and memory size varied. Our experimental results show that (1) the GPU dominates the CPU and the KNL processors on each algorithm, (2) all algorithms scale well with number of threads on the CPU and KNL, and (3) the size of accessed memory area affects each algorithm differently. Based on these results, we recommend CryptoNight with scratchpads of different sizes as the most egalitarian PoW algorithm.
Risk assessment of the total testing process based on quality indicators with the Sigma metrics
Authors: Xia Yong , Wang Xiaoxue , Yan Cunliang , Wu Jinbin , Xue Hao , Li Mingyang , Lin Yu , Li Jie , Ji Ling 
Published: March 2020

Abstract

Background
Evidence-based evaluation of laboratory performances including pre-analytical, analytical and post-analytical stages of the total testing process (TTP) is crucial to ensure patients receiving safe, efficient and effective care. To conduct risk assessment, quality management tools such as Failure Mode and Effect Analysis (FMEA) and the Failure Reporting and Corrective Action System (FRACAS) were constantly used for proactive or reactive analysis, respectively. However, FMEA and FRACAS faced big challenges in determining the scoring scales and failure prioritization in the assessment of real-world cases. Here, we developed a novel strategy, by incorporating Sigma metrics into risk assessment based on quality indicators (QIs) data, to provide a more objective assessment of risks in TTP.

Methods
QI data was collected for 1 year and FRACAS was applied to produce the risk rating based on three variables: (1) Sigma metrics for the frequency of defects; (2) possible consequence; (3) detection method. The risk priority number (RPN) of each QI was calculated by a 5-point scale score, where a value of RPN > 50 was rated as high-risk.

Results
The RPNs of two QIs in post-analytical phase (TAT of Stat biochemistry analyte and Timely critical values notification) were above 50 which required rigorous monitoring and corrective actions to eliminate the high risks. Nine QIs (RPNs between 25 and 50) required further investigation and monitoring. After 3 months of corrective action the two identified high-risk processes were successfully reduced.

Conclusions
The strategy can be implemented to reduce identified risk and assuring patient safety.
The genealogy of teaching clinical reasoning and diagnostic skill: the GEL Study
Authors: Russell Stephen W. , Desai Sanjay V. , O’Rourke Paul , Ahuja Neera , Patel Anand , Myers Christopher G. , Zulman Donna , Sateia Heather F. , Berkenblit Gail V. , Johnson Erica N. , Garibaldi Brian T. 
Published: March 2020

AbstractThe genealogy of graduate medical education in America begins at the bedside. However, today’s graduate medical trainees work in a training environment that is vastly different from medical training a century ago. The goal of the Graduate Medical Education Laboratory (GEL) Study, supported by the American Medical Association’s (AMA) “Reimagining Residency” initiative, is to determine the factors in the training environment that most contribute to resident well-being and developing diagnostic skills. We believe that increasing time at the bedside will improve clinical skill, increase professional fulfillment, and reduce workplace burnout. Our graduate medical education laboratory will test these ideas to understand which interventions can be shared among all training programs. Through the GEL Study, we aim to ensure resident readiness for practice as we understand, then optimize, the learning environment for trainees and staff.
New developments on EDR (Event Data Recorder) for automated vehicles
Authors: Böhm Klaus , Kubjatko Tibor , Paula Daniel , Schweiger Hans-Georg 
Published: March 2020

AbstractWith the upcoming new legislative rules in the EU on Event Data Recorder beginning 2022 the question is whether the discussed data base is sufficient for the needs of clarifying accidents involving automated vehicles. Based on the reconstruction of real accidents including vehicles with ADAS combined with specially designed crash tests a broader data base than US EDR regulation (NHTSA 49 CFR Part 563.7) is proposed. The working group AHEAD, to which the authors contribute, has already elaborated a data model that fits the needs of automated driving. The structure of this data model is shown. Moreover, the special benefits of storing internal video or photo feeds form the vehicle camera systems combined with object data is illustrated. When using a sophisticate 3D measurement method of the accident scene the videos or photos can also serve as a control instance for the stored vehicle data. The AHEAD Data Model enhanced with the storage of the video and photo feeds should be considered in the planned roadmap of the Informal Working Group (IWG) on EDR/ DSSAD (Data Storage System for Automated Driving) reporting to UNECE WP29. Also, a data access over the air using technology already applied in China for electric vehicles called Real Time Monitoring would allow a quantum leap in forensic accident reconstruction.
Charging electric cars as a way to increase the use of energy produced from RES
Authors: Małek Arkadiusz , Caban Jacek , Wojciechowski Łukasz 
Published: March 2020

AbstractThe article contains an analysis of charging electric cars as a way to increase the use of energy produced from a photovoltaic system. A photovoltaic system is described, consisting of two micro installations, with a power output of up to 40 kWp each, supplying two sectors of the building of the Lublin Science and Technology Park. An internet platform for monitoring the operation of a photovoltaic system is presented. Next, an innovative system for monitoring, consumption and production analysis of electric energy in individual building sectors is described. A surplus of energy produced in one of the sectors was found. It was proposed that this excess energy would be used to charge electric vehicles. An analysis of the surplus power generated by the photovoltaic system in excess of the energy consumed by the building sector was used to determine the power available to the wall charger. The surplus of energy produced was used for calculations related to the amount of charging the electric vehicle required and the cost of traveling 100 km. Charging an electric car not only provides a faster return on investment in the installation, but also presents drivers with a very ecological and economical transport solution.
The oxidative coupling between benzaldehyde derivatives and phenylacetylene catalyzed by rhodium complexes via C-H bond activation
Authors: Zhao Xinyi , Jia Hongge , Wang Qingji , Song Heming , Tang Yanan , Ma Liqun , Shi Yongqiang , Yang Guoxing , Wang Yazhen , Zang Yu , Xu Shuangping 
Published: March 2020

Abstract
This paper reports the use of rhodium (Rh) catalysts for the oxidative coupling reaction between phenylacetylene and benzaldehyde derivatives via C-H bond activation. These reactions were catalyzed by Rh(l-amino acid)(cod) (the l-amino acid is l-phenylalanine, l-valine or l-proline; cod is 1,5-cyclooctadiene) to obtain chromones in 12.7–88.3% yield. These new Rh catalysts have excellent activity for the coupling reaction between phenylacetylene and different benzaldehyde derivatives. It was found that the electronic effects of the benzaldehyde derivative substituent affected the reaction yield, which is in accordance with the proposed mechanism.
The effects of circuit resistance training on plasma progranulin level, insulin resistance and body composition in obese men
Authors: Safarzade Alireza , Alizadeh Hamid , Bastani Zainab 
Published: March 2020

Abstract

Background
Progranulin (PGRN) is implicated in obesity and insulin resistance (IR). The aim of this study was to evaluate the effects of 8 weeks of circuit resistance training (CRT) on plasma PGRN, IR and body composition in obese men.

Materials and methods
Twenty-eight healthy obese men [age: 36 ± 7.7 years, body weight (BW): 96.4 ± 15.6 kg, body mass index (BMI): 32.4 ± 4.5 kg/m2] completed the study. Subjects were randomly assigned to two groups of control and training. Subjects in the training group underwent training for 8 weeks, 3 times a week. Blood samples and anthropometric characteristics were taken before the commencement of the exercise protocol and 72 h after the last training session. The homeostatic model assessment of insulin resistance (HOMA-IR) was used to measure IR.

Results
BW, BF%, BMI, waist-hip ratio (WHR), HOMA-IR and plasma PGRN levels except lean body mass (LBM) were significantly reduced in the training group (p < 0.05). Additionally, except for LBM, subjects in the training group had significantly decreased BW, BF%, BMI, WHR, HOMA-IR and plasma PGRN levels compared to changes in those in the control group (p < 0.05). Significant correlations were found between the changes in plasma PGRN and the changes in insulin, HOMA-IR and BMI (p < 0.05).

Conclusions
The findings showed that 8 weeks of CRT improved body composition and IR which were accompanied by reduced plasma PGRN levels. This study suggests that CRT has the potential for obese individuals to counteract obesity-associated health impairments.