bluuebunny/crossref_metadata_2025_split huggingface dataset:
CMR‐based heart deformation analysis for quantification of hemodynamics and right ventricular dysfunction in patients with CTEPH
Authors: Tao Xincao , Liu Min , Liu Weifang , Xie Wanmu , Wan Jun , Zhai Zhenguo , Wang Chen 
Published: December 2019

AbstractIntroductionQuantification of hemodynamics and right ventricular (RV) function is crucial for pulmonary hypertension (PH). Cardiovascular magnetic resonance–based heart deformation analysis (CMR‐HDA) has been used to assess the ventricular strain.ObjectiveThis study was to determine the correlation of right ventricular longitudinal strain (RVLS) assessed with CMR‐HDA with RV function as well as hemodynamics in patients with chronic thromboembolic pulmonary hypertension (CTEPH).MethodsThirty‐six CTEPH patients were prospectively included in this research. Each patients underwent CMR and right heart catheterization (RHC). RVLS and RV ejection fraction (RVEF) was quantified from cine images acquired with a retrospectively gated turbo FLASH gradient‐echo sequence. The late gadolinium enhancement (LGE) images were acquired using a 2D inversion recovery phase‐sensitive fast gradient‐echo sequence. Hemodynamics were determined with RHC.ResultsRight ventricular longitudinal strain measured with CMR‐HDA was −13.99 ± 4.94%. Bland–Altman plots showed statistical agreement with RVLS with low intra‐ and interobserver variability. RVLS correlated with serum N‐terminal‐pro‐B‐type natriuretic peptide (r = 0.615, P < .001). RVLS inversely correlated with RVEF (r = −0.699, P < .001), and it was positively correlated with both RVESV (r = 0.664, P < .001) and myocardial the volume of LGE (r = 0.447, P = .008). Receiver‐operating characteristic (ROC) indicated that RVLS values of >−14.20% could be used to predict RVEF <40% with a 100% sensitivity and a 96.7% specificity. Hemodynamically, RVLS was positively correlated with mean pulmonary artery pressure (r = 0.598, P < .001) and pulmonary vascular resistance (r = 0.685, P < .001).ConclusionRight ventricular longitudinal strain assessed by CMR‐HDA is a readily available and reproducible parameters of RV function. RVLS >−14.20% suggests the presence of RV dysfunction.
Seafloor biodiversity of Canada's three oceans: Patterns, hotspots and potential drivers
Authors: Wei Chih‐Lin , Cusson Mathieu , Archambault Philippe , Belley Renald , Brown Tanya , Burd Brenda J. , Edinger Evan , Kenchington Ellen , Gilkinson Kent , Lawton Peter , Link Heike , Ramey‐Balci Patricia A. , Scrosati Ricardo A. , Snelgrove Paul V. R. 
Published: December 2019

AbstractAimWe examined the relationships between bathymetry, latitude and energy and the diversity of marine benthic invertebrates across wide environmental ranges of Canada's three oceans.LocationCanadian Pacific, Arctic and Atlantic Oceans from the intertidal zone to upper bathyal depths, encompassing 13 marine ecoregions.MethodsWe compiled 35 benthic datasets that encompass 3,337 taxa (70% identified to species and 21% to genus) from 13,172 samples spanning 6,117 sites. Partitioning the analyses by different gear types, ecoregions or sites, we used Hill numbers to examine spatial patterns in α‐diversity. We used resampling and extrapolation to standardized sampling effort and examined the effects of depth, latitude, chemical energy (export particulate organic carbon [POC] flux), thermal energy (bottom temperature) and seasonality of primary production on the benthic biodiversity.ResultsThe Canadian Arctic harboured the highest benthic diversity (e.g. epifauna and common and dominant infauna species), whereas the lowest diversity was found in the Atlantic. The Puget Trough (Pacific), Beaufort Sea, Arctic Archipelago, Hudson Bay, Northern Labrador and Southern Grand Bank (Atlantic) were the “hotspots" of diversity among the ecoregions. The infauna and epifauna both exhibited hump‐shaped diversity–depth relationships, with peak diversity near shelf breaks; latitude (positively) predicted infaunal diversity, albeit weakly. Food supply, as inferred from primary production and depth, was more important than thermal energy in controlling diversity patterns. Limitations with respect to calculating POC flux in coastal (e.g. terrestrial runoff) and ice‐covered regions or biological interactions may explain the negative POC flux–infaunal diversity relationship.Main ConclusionsWe show previously unreported diversity hotspots in the Canadian Arctic and in other ecoregions. Our analyses reveal potential controlling mechanisms of large‐scale benthic biodiversity patterns in Canada's three oceans, which are inconsistent with the prevailing view of seafloor energy–diversity relationships. These results provide insightful information for conservation that can help to implement further MPA networks.
Design and Innovation as Co‐creating and Co‐becoming with the Future
Authors: Peschl Markus F. 
Published: December 2019

Our world has changed radically over the last several decades. Almost every domain of our lives is affected by disruptions in technology—our economy, culture, and education, as well as social lives. We are living in an environment that is characterized by high levels of volatility, uncertainty, complexity, and ambiguity (“VUCA world”). These changes bring about completely new challenges on an individual, an organizational, and a global level. Whereas classical approaches to design and innovation are based on the assumption that we can “solve” these challenges by applying techniques and methods of “problem solving,” of (social) collaboration, co‐creation, or co‐design, this paper challenges this “classical” understanding of “together” and “co‐.”We will develop and take a closer look at three forms of “together” and “co‐,” investigating the relationship between the designer/innovator, his or her material and environment, and the involved stakeholders and their being embedded in ecosystems, as well as the future he or she is designing for: (a) being/working together and collaborating with others (socio‐epistemic dimension); (b) being together, interacting and corresponding with the material/world (co‐becoming dimension); and (c) being together and co‐developing with the future as “learning from the future as it emerges.”It will be shown how these forms of together are related to design and innovation, and we will develop implications concerning new skills and mind‐sets.
Does celiac disease impair coronary microvascular circulation: Coronary flow velocity reserve of patients with celiac disease
Authors: Caliskan Zuhal , Telci Caklili Ozge , Kahraman Resul , Ozcan Fatma Betul , Sayar Suleyman , Kostek Osman , Demircioglu Kenan , Yilmaz Yusuf , Kul Seref , Caliskan Mustafa 
Published: December 2019

AbstractBackgroundCeliac disease (CD) is an enteropathy characterized with immune reaction to gliadin protein.AimIn this study, we aimed to assess effect of CD on coronary microvascular circulation and the association between coronary flow velocity reserve (CFVR) and hs‐CRP/Albumin ratio.Material and MethodsStudy was conducted between March 2017 and November 2018 with CD at Umraniye Training and Research Hospital Gastroenterology Clinic. CFVR was defined as the ratio of hyperemic to baseline diastolic peak velocities. CFVR ≥ 2.0 was considered normal. C‐reactive protein/albumin ratio (CAR) was calculated as hs‐CRP/albumin.ResultsSerum albumin (4.27 ± 0.56 vs 4.50 ± 0.34; P value: .04) level was significantly lower in celiac group but higher Hs‐CRP (2.44 ± 1.24 vs 1.82 ± 1.29; P value < .01), hs‐CRP/albumin ratio (0.57 ± 0.30 vs 0.41 ± 0.31; P value: .03) were recorded in celiac group. Both hyperemic flow and CFVR substantially lower in the celiac group compared to controls. In univariate analysis; age, hs‐CRP, and hs‐CRP/albumin ratio were associated with low CFVR and hs‐CRP/albumin level was an accurate predictor of low CFVR at the ROC curve.ConclusionIn this study, we found that in patients with CD, coronary flow reserve is impaired.
Triiodothyronine secretion in early thyroid failure: The adaptive response of central feedforward control
Authors: Hoermann Rudolf , Pekker Mark J. , Midgley John E. M. , Larisch Rolf , Dietrich Johannes W. 
Published: December 2019

AbstractBackgroundDefined by thyroid‐pituitary feedback control, clinical diagnosis of hypothyroidism and hyperthyroidism has become synonymous with TSH measurement. We combined in silico analysis and in vivo data to explore the central influences on thyroidal T3 production.Materials & methodsA system of five coupled first‐order nonlinear parameterised ordinary differential equations (ODEs) is used to model the feedback control of TSH and TRH by thyroid hormones together with the feedforward control of thyroidal T3 secretion and enzymatic T4‐T3 conversion. Dependencies of the stable equilibrium solutions of this ODE system, that is the homeostasis of the underlying physiological process, on the system parameters were investigated whether they accounted for clinical observations.ResultsDuring the modelled transition to hypothyroidism, central control imposed an increasing influence in maintaining serum FT3 levels, compared to peripheral conversion efficiency. Numerical continuation analysis revealed dependencies of T3 production on different elements of TSH feedforward control. While T4‐T3 conversion provided the main T3 source in euthyroidism, this was overtaken by increasing glandular T3 secretion when thyroid reserve declined. The computational results were in good agreement with data from untreated patients with autoimmune thyroiditis.ConclusionsDependencies revealed in the expression of control differ in thyroid health and disease, using a physiologically based mathematical model of combined feedback‐feedforward control of the hypothalamic‐pituitary‐thyroid regulation. Strong T3‐protective mechanisms of the control system emerge with declining thyroid function, when glandular T3 secretion becomes increasingly influential over conversion efficiency. This has wide‐ranging implications for the utility of TSH in clinical decision‐making.
A tale of three marketplaces: Chinese commodities, European fairs, Vietnamese entrepreneurs
Authors: MAROUDA MARINA 
Published: December 2019

AbstractThis article is based on ethnographic research undertaken over the course of a year (2017) in three wholesale marketplaces situated in Warsaw (Poland), Odessa (Ukraine) and Yiwu (China). Daily transactions in these wholesale fairs span different continents, linking East Asia to Eastern Europe. Key in assembling such far‐reaching trading networks are Chinese‐made commodities, Vietnamese diasporas and European trade regulations. In this article, I pay particular attention to entrepreneurial Vietnamese as they sojourned to Eastern Europe, originally as part of exchanges that sought to create a ‘socialist ecumene’.
Structure and stability of edible oleogels prepared with different unsaturated oils and hydrocolloids
Authors: Bascuas Santiago , Hernando Isabel , Moraga Gemma , Quiles Amparo 
Published: December 2019

SummaryEdible oleogels, with three oil types (olive, sunflower and flaxseed), hydroxypropylmethylcellulose (HPMC) and xanthan gum (XG), as structuring agents, were developed using the emulsion‐template approach, and subsequent drying of the emulsions using conventional or vacuum drying. Our results showed that for both drying methods, well‐structured oleogels were obtained using olive and sunflower oils for the preparation. These oleogels showed oil losses ˂10% after 35 days of storage. However, unstructured non‐homogeneous oleogels were obtained when using flaxseed oil and conventional drying, while it was not feasible to develop flaxseed oleogel with vacuum drying. Oleogels showed interesting rheological properties, including a high oleogel strength with an elastic modulus of the order 104–105 Pa, weak dependence on frequency, and good thermostability. Moreover, high oxidative stability was obtained for olive oil oleogels, using both conventional and vacuum drying, and for sunflower oleogels using vacuum drying. Still, the initial oxidation rates of sunflower oleogels using conventional drying should be improved in future studies.
Determining the local pressure during aerosol deposition using glass memory
Authors: Cicconi Maria Rita , Khansur Neamul H. , Eckstein Udo R. , Werr Ferdinand , Webber Kyle G. , de Ligny Dominique 
Published: December 2019

AbstractAerosol deposition (AD) is a dynamic loading process that can be envisioned as a shock wave loading, necessitating the consideration of the elastic/plastic response of solid materials. Due to the dynamic nature of this process, however, experimental determination of the local pressures during the deposition process is difficult. This work addresses this by investigating the compression and subsequent structure modification of a silicate glass after room‐temperature AD on a silicate glass substrate with Raman spectroscopy. Clear structural changes in the short‐ and middle‐range order of the silicate glass were observed, both as intertetrahedral angle distribution and as ring statistic. Therefore, the AD induced permanent densification of the glass, equivalent, in a hydrostatic approximation, to a minimal pressure of 10.5 ± 1.5 GPa during the film deposition process. Furthermore, the analysis of the Nd3+ photoluminescence of the 4F3/2 − 4I9/2 transition provided complementary information on the glass network modifications occurring during film formation. More than a pure hydrostatic densification, the AD seems to present a very intense shear deformation. This work opens up the perspective of evaluating the mechanical response of film‐substrate and of the particles themselves, and provides critical information on the mechanisms responsible for the AD film formation.
Experimental study of bubble formation in a glass‐forming liquid doped with cerium oxide
Authors: Pereira Luiz , Podda Olivier , Fayard Barbara , Laplace Annabelle , Pigeonneau Franck 
Published: December 2019

AbstractThis work aims to study the mechanisms of oxygen bubble formation coming from redox reaction of a polyvalent element incorporated in a glass melt. Borosilicate glass composition is selected for its use as a glass matrix for nuclear waste conditioning. Cerium is selected as a polyvalent element as it may be found in nuclear waste. The chosen material is characterized in terms of physical properties which influence bubble formation and growth. A postmortem optical microscope approach is used to observe bubbles in the investigated material after thermal treatment for varying temperatures (900°C‐1100°C) and durations. To support the understanding of oxygen bubble formation, cerium speciation by X‐ray absorption near‐edge structure (XANES) and bubble gas composition are experimentally evaluated. In this article, we indicate how bubbles are formed in the investigated glass melt system. It is also demonstrated that the mechanisms that govern bubble evolution are fundamentally the same and that the plot's optimum points are strongly influenced by the temperature. These last statements are confirmed by considering some bubble features, such as bubble mean density and bubble mean diameter evolutions, and normalizing the experimental time using a characteristic residence time (tη) obtaining thereafter a dimensionless time, which is a function of the glass melt properties obtained by the physical characterizations. The impact of temperature and time on bubble formation is described.
Mechanical properties, oxygen barrier property, and chemical stability of RE3NbO7 for thermal barrier coating
Authors: Yang Jun , Pan Wei , Han Yi , Zhao Meng , Huang Muzhang , Wan Chunlei 
Published: December 2019

AbstractRare earth niobate (RE3NbO7, RE = Dy, Y, Er, Yb) ceramics have shown extremely low thermal conductivity but remain questionable in high temperature thermal barrier coating (TBC) applications with high thermal, mechanical, and chemical loads. Herein, we comprehensively characterize the properties of rare earth niobates, including mechanical properties, oxygen barrier properties, chemical stability, etc. It is found that the oxygen conductivities of the rare earth niobates are three orders of magnitude lower than 7wt.% yttria‐stabilized zirconia (YSZ), indicating a remarkable oxygen barrier property to avoid oxidation of underlying metallic components. The corrosion resistance of rare earth niobate against calcium‐magnesium‐aluminum silicate (CMAS) is also significantly better than that of YSZ. Together with the extremely low thermal conductivity, the rare earth niobates exhibit a combination of excellent high temperature properties, which may become a promising candidate material of high temperature TBC of next generation gas turbines.
2020 Consensus summary on the management of hypertension in Asia from the HOPE Asia Network
Authors: Kario Kazuomi , Park Sungha , Chia Yook‐Chin , Sukonthasarn Apichard , Turana Yuda , Shin Jinho , Chen Chen‐Huan , Buranakitjaroen Peera , Divinagracia Romeo , Nailes Jennifer , Hoshide Satoshi , Siddique Saulat , Sison Jorge , Soenarta Arieska Ann , Sogunuru Guru Prasad , Tay Jam Chin , Teo Boon Wee , Zhang Yu‐Qing , Van Minh Huynh , Tomitani Naoko , Kabutoya Tomoyuki , Verma Narsingh , Wang Tzung‐Dau , Wang Ji‐Guang 
Published: December 2019

AbstractHypertension professionals from Asia have been meeting together for the last decade to discuss how to improve the management of hypertension. Based on these education and research activities, the Hypertension, brain, cardiovascular and renal Outcome Prevention and Evidence in Asia (HOPE Asia) Network was officially established in June 2018 and includes experts from 12 countries/regions across Asia. Among the numerous research and review papers published by members of the HOPE Asia Network since 2017, publications in three key areas provide important guidance on the management of hypertension in Asia. This article highlights key consensus documents, which relate to the Asian characteristics of hypertension, home blood pressure monitoring (HBPM), and ambulatory blood pressure monitoring (ABPM). Hypertension and hypertension‐related diseases are common in Asia, and their characteristics differ from those in other populations. It is essential that these are taken into consideration to provide the best opportunity for achieving “perfect 24‐hour blood pressure control”, guided by out‐of‐office (home and ambulatory) blood pressure monitoring. These region‐specific consensus documents should contribute to optimizing individual and population‐based hypertension management strategies in Asian country. In addition, the HOPE Asia Network model provides a good example of the local interpretation, modification, and dissemination of international best practice to benefit specific populations.
Impact of pre‐existing hypertension and control status before atrial fibrillation onset on cardiovascular prognosis in patients with non‐valvular atrial fibrillation: A real‐world database analysis in Japan
Authors: Kario Kazuomi , Abe Toru , Kanegae Hiroshi 
Published: December 2019

AbstractHypertension is an important risk factor for non‐valvular atrial fibrillation (NVAF) and its prognosis. However, there is no study to clarify the impact of pre‐existing hypertension and BP control status before the onset of AF on the prognosis after the onset of AF. This retrospective real‐world cohort analysis used data from the Japan Medical Data Center Co., Ltd database. The presence of NVAF and hypertension, plus the occurrence of adverse events, was based on ICD‐10 codes in the database. The primary composite AF‐related cardiovascular event end point included ischemic stroke, hemorrhagic stroke, and acute myocardial infarction. Of the 21 523 patients identified as having new‐onset NVAF between January 2005 and June 2016, 7885 had blood pressure (BP) data before the onset of NVAF available and were included in the analysis (4001 with pre‐existing hypertension and 3884 without pre‐existing hypertension). The rate of primary composite end point events was 10.3 and 4.4 per 1000 patient‐years in patients with and without hypertension, respectively (P < .001). In addition, lower systolic BP (<120 mm Hg) before the onset of NVAF was associated with a lower incidence of cardiovascular events after the development of NVAF (P < .001). This highlights the importance of earlier and tighter 24‐hour BP control before the onset of NVAF in patients with hypertension, not only for reducing the occurrence of new‐onset of NVAF, but also for reducing both hemorrhagic and ischemic cardiovascular events after the onset of NVAF.
Utilization of antihypertensive drugs among chronic kidney disease patients: Results from the Chinese cohort study of chronic kidney disease (C‐STRIDE)
Authors: Liu Bianling , Wang Qin , Wang Yu , Wang Jinwei , Zhang Luxia , Zhao Minghui ,   On behalf of the C‐STRIDE study group
Published: December 2019

AbstractThe utilization of antihypertensive drugs plays an important role in blood pressure control among chronic kidney disease (CKD) patients. Limited information was available on how antihypertensive drugs were used among Chinese CKD patients. In the present study, the utilization of antihypertensive drugs among a subgroup of hypertensive participants with a complete record of antihypertensive drug information from the Chinese Cohort Study of Chronic Kidney Disease was analyzed. Among 2213 subjects, 61.7% and 26.5% had their blood pressure controlled to <140/90 mmHg and <130/80 mmHg, respectively. In total, 38.5% were on monotherapy. Of those patients who received combination therapy, 57.8% were treated with a two‐drug combination. Renin‐angiotensin system inhibitors (RASIs) were the most commonly prescribed drugs (71.2%). Only 10.2% of the patients were prescribed diuretics. After multivariable adjustment, participants taking RASI were more likely to have their blood pressure controlled to <140/90 mmHg (prevalence ratio (PR) 1.153, 95% confidence interval (CI): 1.071‐1.240). CKD stage 4 (PR 0.548, 95% CI: 0.434‐0.692) was associated with RASIs treatment. Additionally, diabetes (PR 1.498, 95% CI: 1.120‐2.004), albumin/creatinine ratio ≥300 mg/g (PR 1.547, 95% CI: 1.020‐2.344), and CKD stage 4 (PR 2.022, 95% CI: 1.223‐3.343) were associated with diuretic use. The results suggested that combination therapy, diuretics use in general, and utilization of RASIs in advanced CKD stage were insufficient in the current treatment of Chinese hypertensive CKD patients.
A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis
Authors: Che Xuan , Wang Jianzhang , He Jiayi , Yu Qin , Sun Wenting , Chen Shuyi , Zou Gen , Li Tiantian , Guo Xinyue , Zhang Xinmei 
Published: December 2019

AbstractAdenomyosis is also called internal endometriosis and affects about 20% of reproductive‐aged women. It seriously reduces life quality of patients because current drug therapies face with numerous challenges. Long‐term clinical application of mifepristone exhibits wonderful therapeutic effects with mild side‐effects in many disorders since 1982. Since adenomyosis is a refractory disease, we investigate whether mifepristone can be applied in the treatment of adenomyosis. In this study, we investigated the direct effects of mifepristone on human primary eutopic endometrial epithelial cells and stromal cells in adenomyosis. We found that mifepristone causes cell cycle arrest through inhibiting CDK1 and CDK2 expressions and induces cell apoptosis via the mitochondria‐dependent signalling pathway in endometrial epithelial cells and stromal cells of adenomyosis. Furthermore, mifepristone inhibits the migration of endometrial epithelial cells and stromal cells through decreasing CXCR4 expression and restricts the invasion of endometrial epithelial cells via suppression of epithelial‐mesenchymal transition in adenomyosis. We also found that mifepristone treatment decreases the uterine volume, CA125 concentration and increases the haemoglobin concentration in serum for adenomyosis patients. Therefore, we demonstrate that mifepristone could serve as a novel therapeutic drug in the treatment of adenomyosis, and therefore, the old dog can do a new trick.