bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Land Use Change on Seasonal Water Quality, Case Study in Chi-Mun River Basin in Thailand
Authors: Pakoksung Kwanchai , Inseeyong Nantawoot , Chawaloesphonsiya Nattawin , Punyapalakul Patiparn , Chaiwiwatworakul Pichet , Xu Mengzhen , Chuenchum Pavisorn 
Published: December 2024

Abstract

This study investigates the correlation between land use changes and water quality in the Chi-Mun River Basin, Thailand, from 2007 to 2021. It is the first of its kind in the region and the Mekong River Basin, providing critical insights for global river basin management. The research analyzes spatial and temporal land use changes and their multi-scale impacts on water quality, utilizing land use change estimation, water quality index analysis, and redundancy analysis (RDA). The results showed that stream water quality variables displayed highly temporal variations, with pH, Biochemical Oxygen Demand (BOD), Total Coliform Bacteria (TCB), Fecal Coliform Bacteria (FCB), Total Phosphorus (TP), Nitrate Nitrogen (NO3-N), Ammonia-nitrogen (NH3-N), Suspended Solids (SS) all generally displaying higher levels in the wet season, while there were higher concentrations of Dissolved Oxygen (DO), Electrical Conductivity (EC), and Water Quality Index (WQI) in the dry season. The water samples were collected once in January, March, May, and August from 2007 to 2024. The water quality in wet season is represented in May and August, while in dry season is represented in January and March. The total contribution of land use patterns on overall water quality was stronger during the wet season. It shows a decline in paddy and forest areas alongside an expansion of urban, agricultural, and aqua agricultural land. Water quality displayed significant seasonal variations, with forests and water bodies contributing to purification, while agricultural and urban areas degraded water quality. The findings offer recommendations for water quality protection and land management policies that align with the basin’s natural and socio-economic characteristics, promoting coordinated regional development.
Serum biochemical markers and rheumatoid arthritis: Insights from observational study and Mendelian randomization analysis
Authors: Fan Fangzhou , Tan Hao , Xie Yuxin , Qin Hao , Zhang Chengxuan , Wang Huaao , Yan Wenlong , Zhou Aiguo , Liu Lei , Lian Chengjie 
Published: December 2024

Abstract

Objectives: To identify the specific serum biochemical markers that exhibit causal associations with the risk rheumatoid arthritis (RA)
Methods: A cross-sectional study based on the NHANES database was conducted to investigate which serum biochemical markers were significantly associated with RA. Two-sample Mendelian randomization (MR) and Generalized summary data-based Mendelian randomization (GSMR) analysis were employed to analyze the causal relationships between biomarkers exhibiting differential expression identified within the NHANES database. The primary MR analysis utilized the inverse variance weighted (IVW) method. Restricted cubic spline (RCS) regression was conducted to explore non-linear associations between variables.
Results: The NHANES cohort included 1,416 participants with clinically diagnosed RA and 3,744 control participants without RA. GSMR analysis revealed a significant causal relationship between serum albumin and RA risk (OR = 0.80, 95% CI: 0.72-0.89, P = 3.67×10−5). The IVW meta-analysis also confirmed that decreased albumin expression significantly associated with decreased risk of RA (P = 0.002). A four-node RCS model demonstrated non-linear correlations between albumin, uric acid, and RA (all P non-linear < 0.05), while calcium, globulin, and lactate dehydrogenase (LDH) exhibited linear relationships (all P non-linear > 0.05). However, multiple MR methods did not show any significant causal association between calcium, LDH, urate, and RA risk.
Conclusion: This study found a linear association between calcium, globulin, LDH, and RA risk, while a U-shaped non-linear relationship between albumin, uric and RA was observed. MR analysis revealed a significant causal association between albumin and RA. However, the molecular mechanisms by which albumin affects the risk of RA remain to be further elucidated.
Supplementation with Essential Amino Acids in the Early Stage of Carbohydrate Reintroduction after a Very-Low Energy Ketogenic Therapy (VLEKT) Improves Body Cell Mass, Muscle Strength and Inflammation.
Authors: Annunziata Giuseppe , Verde Ludovica , D’Orsi Vincenzo , Caprio Massimiliano , Gorini Stefania , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna , Barrea Luigi 
Published: December 2024

Abstract

Background
Although little is yet known about the long-term maintenance of very low-energy ketogenic therapy (VLEKT) effects on body composition, muscle strength and inflammation, it is plausible to assume that changes may occur, particularly during the steps following the ketogenic step, due to the loss of the protective effects of ketones and the concomitant reintroduction of carbohydrates. For this reason, the present study aimed to evaluate the effects of supplementation with 8 g per day of essential amino acids (EAAs) on these parameters.
Methods
A total of 68 women of reproductive age and with grade I obesity who had completed 45 days of the ketogenic phase with VLEKT (KeNuT protocol) and 40 days of non-ketogenic phase of KeNuT protocol with VLEKT (phase 3, fruit reintroduction) were included in the study. Half of them (n = 34) followed this first step of the re-educational phase of KeNuT protocol with VLEKT with supplementation with EAAs (Aminotrofic®: 4 g twice daily). Anthropometric parameters, body composition via bioelectrical impedance analysis and high-sensitivity C-reactive protein (hs-CRP) levels were assessed at baseline, pre- and post both dietary interventions.
Results
At the end of 45 days of ketogenic phase with VLEKT (before fruit reintroduction and EAA supplementation), the two groups did not differ in any of the parameters assessed. At the end of the fruit reintroduction phase, the supplemented group showed greater magnitudes of reduction in weight, waist circumference, fat mass (FM) and hs-CRP (p < 0.001 for all) and of increase in muscle strength (p < 0.001), phase angle (p < 0.001), body cell mass (BCM) (p = 0.001), and muscle mass (%) (p < 0.001).
Conclusion
These results underline the usefulness of supplementation with EAAs during the first transitional phase post VLEKT to improve body composition (specifically reduction in FM and increase in BCM), muscle strength, and inflammatory status.
A national study on knowledge of child language development, self-efficacy, and the professional development of childcare providers in Saudi Arabia
Authors: Alaslani Khadeejah , Almohammadi Alaa , Alroqi Haifa , Aljahlan Yara , Alsulaiman Roaa , Albeeshi Aalya , Murad Abdullah , Alnemary Fahad 
Published: December 2024

Abstract

This country-wide study explores the landscape of childcare providers (CPs) in Saudi Arabia, illuminating their pivotal role in fostering children’s language skills. While fundamental, our understanding of their status in Saudi Arabia remains limited. This study provides a comprehensive profile of CPs, exploring their knowledge of child language development, self-efficacy, and their interplay with work experience, education, and training. Key findings indicate that merely a quarter of CPs hold a degree in early childhood education. A significant positive association was found between CPs’ knowledge of child language development and their perceived self-efficacy, and a moderately significant positive association was found between CPs’ knowledge of language development and professional training received. CPs’ self-efficacy was significantly predicted by their knowledge of language development and the training received. The implications underscore the urgency of targeted professional development initiatives to enhance the quality of early childhood education in Saudi Arabia. Policymakers should address the concerning trend where a significant portion of entrusted professionals lacks specialization in early childhood, raising critical questions about the alignment of educational qualifications with the demands of early childhood education. These insights offer a compelling basis for policymakers to advocate evidence-based practices and guide future research in the field.
Chronic Phase Nasal Intermittent Ventilation in Neonates with Grade 3 Bronchopulmonary Dysplasia
Authors: Weems Mark , Lamba Vineet , Chilakala Sandeep , Murdock L. Brooke , Rana Divya , Sakaria Rishika , Zaveri Parul , Ramanathan Rangasamy 
Published: December 2024

Abstract

Objective
We describe a novel strategy of chronic-phase nasal intermitted positive pressure ventilation (cNIPPV) to support patients with bronchopulmonary dysplasia (BPD) and avoid tracheostomy.
Study Design
This is a retrospective study of Grade 3 BPD patients discharged from a single center January 2020 to May 2024. Patients were divided into groups treated with cNIPPV or with tracheostomy. Groups were assessed for clinical differences, and the cNIPPV strategy was described.
Result
There were 28 cNIPPV and 20 tracheostomy patients. There were no differences between groups for gestational age, birthweight, or respiratory severity score at key dates. Tracheostomy patients were more likely to have subglottic stenosis (55 vs 3.6%, p < 0.0001). Tracheostomy patients were older at discharge home [median 447 (411–514) vs 252 (184–309) days, p < 0.0001].
Conclusion
A subset of Grade 3 BPD patients can be supported with cNIPPV and avoid tracheostomy. This strategy may be associated with decreased length of hospital stay.
Optimisation of thermal characteristics of buried composite phase change energy storage walls
Authors: Diao Rongdan , Cao Yinqiu , chi congwen , Michel Mushagalusa Murhambo , Guan Yajuan , Guerrero Josep M 
Published: December 2024

Abstract

Improving the thermal insulation performance of building walls is the most effective way to save energy in buildings. In this paper, multiple construction forms of embedded composite phase change energy storage wall are proposed to study the heat transfer characteristics of the wall and its influence on the indoor thermal environment. The heat transfer law and mechanism of wall influence on indoor thermal environment are revealed. The results show that the error between the measured results and the numerical simulation results is less than 10%, which verifies the feasibility of studying the heat transfer performance of the phase-change wall by numerical simulation method. Under the condition that water does not flow, the temperature difference at the base of ordinary wall, S font, U font and back font phase change energy storage wall is 8.70℃, 8.80℃, 8.83℃ and 8.94℃, respectively. Under the working condition of water flow, the temperature difference of S-font, U-font and back-font phase change energy storage wall base is 5.00℃, 5.18℃ and 6.51℃, respectively. The smaller the coil spacing, the better the heat storage performance of the phase change wall. The phase-change energy storage wall can reduce the maximum indoor air temperature by 3.2℃, and effectively improve the indoor thermal comfort.
Research Hotspots and Cutting-edge Trends in Intertrochanteric Femur Fracture from 1999 to 2024: A Bibliometric Analysis
Authors: deng xin , su yun , fu yutian , zhang haochun , zhang yongkun , meng xiangjun 
Published: December 2024

Abstract

Purpose The objective of this study was to uncover the current primary research topics within the field of IFF through a comprehensive statistical analysis of available literature sources, while also providing insights into potential future advancements.Methods Literature on IFF, published from the establishment of the database until April 2024 was retrieved from the Web of Science database. Statistical analyses were performed using Microsoft Office Excel 2021 and a bibliometric online analysis platform. Literature visualization analysis was performed using a citespace.6.3. R1 software.Results A total of 3424 articles were retrieved, including 3211 research articles and 213 review articles. Literature on IFF has consistently shown an annual increase in quantity. Articles pertaining to this field have been published by 80 countries or regions globally, with the United States leading in both publication volume and total citations. J ORTHOP TRAUMA had the highest number of publications (138 articles), while the University of California System emerged as the most prolific institution with 64 articles. Professor Yingze Zhang has made significant contributions to the literature in this domain. Co-occurrence analysis revealed three primary categories for relevant keywords associated with IFF: clinical classification research, treatment, and complications.Conclusions The incidence and number of patients with IFF are expected to continue increasing, leading to subsequent growth in the volume of literature on this topic over the next decade. Future research should focus on investigating risk factors and treatment methods for IFF, particularly within the realm of treatment strategies.
Identification and validation of PANoptosis-based HNSCPAN-index as a prognostic model for head and neck squamous cell carcinoma
Authors: Feng Yekai , Tang Qinglai , Tang Xiaojun , Zeng Miao , Zang Yuming , Li Shisheng 
Published: December 2024

Abstract

PANoptosis, a recently characterized form of programmed cell death, remains incompletely understood in the context of Head and Neck Squamous Cell Carcinoma (HNSCC). In this study, we identified a prognostically relevant set of PANoptosis genes within The Cancer Genome Atlas (TCGA) database for HNSCC and uncovered three molecular subtypes based on their expression profiles. Each subtype exhibited distinct prognostic outcomes and immune cell infiltration patterns. To further elucidate the clinical relevance, we constructed a PANoptosis risk score model, termed the HNSCPAN-index, using least absolute shrinkage and selection operator (LASSO) Cox regression based on differentially expressed genes across the subtypes. Patients were stratified into high-risk and low-risk groups according to the HNSCPAN-index. The predictive power of the model was evaluated using Kaplan-Meier analysis, ROC, nomogram and validated using an external dataset. A lower HNSCPAN-index correlated with longer overall survival and enhanced immunotherapy responses, whereas a higher HNSCPAN-index indicated increased sensitivity to small-molecule targeted therapies. Moreover, the HNSCPAN-index demonstrated a strong correlation with chemotherapeutic drug sensitivity. Finally, DSCAM was identified as a key regulator in HNSCC, where silencing DSCAM expression enhanced cell death mediated by pyroptosis inducers. In conclusion, we constructed a risk model of PANoptosis in HNSCC and revealed its potential role in prognosis, TME, chemotherapy. These findings may provide a deeper understanding of PANoptosis in HNSCC and pave the way for the development of more personalized therapeutic strategies.
Epithelial Cell Adhesion Molecule accurately identifies pulmonary carcinoma metastases in lymph nodes
Authors: McGovern Kelly A. , Welch Katherine O. , Krouse Ryan , Brown Michael , Chen Lydia , Guo Kevin , Huang Jeffrey , Mlakar Jake , Delikatny Jim , Gruev Viktor , Zhang Paul , Singhal Sunil 
Published: December 2024

Abstract

Lymph node (LN) excision is critical in oncologic surgery to provide important therapeutic and diagnostic information. LN evaluation helps in staging cancers, predicting prognosis and improving survival. The ultimate wish of a surgical oncologist would be to localize and dissect all pathologically positive LNs while avoiding the morbidity of removing true negative LNs. The goal of our study was to identify a reliable marker for clinical prediction of LNs with cancer cells from non-small cell lung cancer (NSCLC) versus a LN without. We identified Epithelial Cell Adhesion Molecule (EpCAM), a membrane protein normally expressed in epithelial tissues including in lung. We used human specimens immunostained with anti-EpCAM monoclonal antibody. EpCAM was expressed in NSCLC metastasis to LNs as shown in 74 positive LNs from patients with resected primary NSCLC. Among pathologically negative LNs, regardless of PET avidity, EpCAM was absent; whereas among pathologically positive LNs, all PET uptake groups exhibited high EpCAM positivity. Together, this biomarker had a 100% accuracy. There was no difference in expression between hilar and mediastinal LNs, nor between primary tumor histology. EpCAM may be useful for the surgical oncologist for preoperative or intraoperative detection of positive LNs from NSCLC.
Classification of childhood obesity using longitudinal clinical body mass index and its validation
Authors: Thaker Vidhu , Ebrahim Nia , Khadegi Apurva , Deng Shuliang , Qian Kun , Yao Zonghui , Thaker Shaleen , May Benjamin , Patibandala Nandan , Lopez-Pintado Sara 
Published: December 2024

Abstract

Objective: Persistence of childhood adiposity is known to be associated with long-term adverse cardiometabolic risks. Yet, cross-sectional body mass index (BMI) is often used to classify obesity in clinical care and research. This study aimed to develop and validate a childhood obesity classification system using longitudinal clinical data.
Methods: This observational study used electronic health record data from a tertiary care hospital, with replication in an independent cohort. For individuals with ≥ 3 BMI measurements, the median BMI percentile and persistence in the obesity class were used for longitudinal classification. The association between longitudinal BMI class and early onset obesity, socioeconomic status (SES), and adverse cardiometabolic risk was analyzed.
Results: Height, weight, and cardiometabolic risk measures were obtained for 22 352 children from 2014-18 in the primary cohort and 24 444 children in the replication cohort. Obesity (BMI ≥ 95th percentile [BMIpct95]) was observed in 24.1% and severe obesity (BMI ≥ 120% of BMIpct95) in 10.6%. Individuals with early onset obesity (age ≤ 6 years) remained in the same or higher obesity class; those in the high-SES group had lower odds of obesity. The proportion of individuals with cardiometabolic risk increased with increasing obesity severity (p-value 0.01 - < 0.001). The AUC for cardiometabolic risk by longitudinal BMI class was higher compared to that for cross-sectional BMI (80.0% vs. 75.8%, p < 0.001).
Conclusions: The Longitudinal BMI classification may better reflect long-term cardiometabolic risk in children. This classification can be useful for focused intervention strategies and for profiling of individuals for genetic testing.
Disrupted topological organization of brain connectome in patients with chronic low back-related leg pain and correlations with clinical characteristics
Authors: Ji Yuqi , Liang Xiao , Pei Yixiu , Zuo Xiaoying , Zhu Yanyan , Xu Jie , Kuang Qinmei , Yang Ziwei , Zhou Fuqing , Zhang Yong 
Published: December 2024

Abstract

Chronic pain is associated with persistent alterations in brain structure and function. However, existing research has not fully explored the relationship between brain network topological properties and clinical symptoms in patients with chronic low back-related leg pain (cLBLP). In this study, we collected resting-state functional and structural magnetic resonance imaging (MRI) data, along with clinical symptom evaluation data, from 32 cLBLP patients and 31 healthy controls. A large-scale complex network analysis was conducted to evaluate the global and nodal topological properties of functional and structural brain networks. Statistical analyses were performed to determine the associations between network properties and clinical variables. The results showed significant alterations in both global and nodal topological properties of functional and structural brain networks in cLBLP patients compared to healthy controls. Notably, nodal properties of functional brain networks were also altered in patients. Additionally, a direct correlation was found between structural network properties and spatial discrimination ability, measured by two-point tactile discrimination (2-PD) values, while no significant association was observed between functional connectivity and spatial discrimination. This study demonstrates that alterations in the structural connectome, rather than the functional connectome, play a more significant role in deterioration of foot tactile spatial acuity in cLBLP patients.
Cytomegalovirus DNA doubling time for early identification of clinically significant infection episodes in allogeneic hematopoietic stem cell transplant recipients undergoing primary Letermovir prophylaxis: A multicenter study
Authors: Navarro David , Giménez Estela , García-Cadenas Irene , Piñana Jose Luis , Albert Eliseo , Vázquez Lourdes , Avendaño Alejandro , Cabrero Mónica , Esqu Albert , Martino Rodrigo , Jimenez Javier Lopez , Cuesta Marian , Humala Karem , Villar Sara , Rovira Montse , Heras Inmaculada , Ripa María Zudaire , Arroyo Ignacio , Zabalza Amaya , Aguado Beatriz , Solano Carlos 
Published: December 2024

Abstract

We evaluated the potential of Cytomegalovirus (CMV) DNA doubling time (dt) in plasma to distinguish between clinically significant CMV infection (CsCMVi) and abortive CMV infection in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients on primary letermovir (LMV) prophylaxis. Data from the Spanish Hematopoietic Transplantation and Cell Therapy Group multicenter registry included 296 allo-HSCT patients receiving LMV prophylaxis. Participating centers used a plasma CMV DNA threshold of ≥ 1,000 IU/ml for initiating preemptive antiviral therapy (PET). The CMV DNA dt was calculated from the first two or three positive PCR results based on pre-established criteria. CMV DNAemia developed in 64 recipients (21.6%) with a total of 88 episodes, of which CsCMVi occurred in 9 recipients (3.04%) and included 10 episodes (one patient had confirmed CMV gastrointestinal disease). A non-calculable CMV DNA dt had a negative predictive value (NPV) of 94% for CsCMVi. For initial episodes with calculable CMV DNA dts (4/7 CsCMVi and 8/57 no-CsCMVi), a threshold of ≤ 2.35 days had a positive predictive value of 100% for CsCMVi. CMV DNA dt could optimize CMV infection management in allo-HSCT patients under LMV prophylaxis, independent of the PCR platform used.