bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two‐way immersion teacher preparation
Authors: Hood Sally J. 
Published: February 2020

AbstractThe purpose of this qualitative study was to document the skills, knowledge, and dispositions needed for effective two‐way immersion (TWI) teacher training based on the perspectives of those practicing in the field. The research questions explored how preservice teachers, practicing TWI teachers, and TWI administrators perceived the skills, knowledge, and dispositions needed for effective TWI teaching, how they viewed the challenges for TWI teacher preparation programs and the role of a TWI field experience. The findings revealed that field experiences in a TWI classroom are essential for learning the complex pedagogy required for effective dual language education. The findings also showed that long‐term study abroad experiences in regions other than the mother country are necessary for expanding novice TWI teachers' language skills, specifically the learning of other dialects. Additional findings showed that TWI teachers' work extends beyond typical teacher capabilities, such as the teaching of academic content and literacy in two languages. This study also found that passion is fundamental for effective TWI teaching because it can inspire teachers to advocate for the program model and multilingualism. Based on the findings, the researcher recommends that TWI teacher preparation programs require specialized dual language education courses and field experiences.
Bat‐borne viruses in Africa: a critical review
Authors: Markotter W. , Coertse J. , De Vries L. , Geldenhuys M. , Mortlock M. 
Published: February 2020

AbstractIn Africa, bat‐borne zoonoses emerged in the past few decades resulting in large outbreaks or just sporadic spillovers. In addition, hundreds of more viruses are described without any information on zoonotic potential. We discuss important characteristics of bats including bat biology, evolution, distribution and ecology that not only make them unique among most mammals but also contribute to their potential as viral reservoirs. The detection of a virus in bats does not imply that spillover will occur and several biological, ecological and anthropogenic factors play a role in such an event. We summarize and critically analyse the current knowledge on African bats as reservoirs for corona‐, filo‐, paramyxo‐ and lyssaviruses. We highlight that important information on epidemiology, bat biology and ecology is often not available to make informed decisions on zoonotic spillover potential. Even if knowledge gaps exist, it is still important to recognize the role of bats in zoonotic disease outbreaks and implement mitigation strategies to prevent exposure to infectious agents including working safely with bats. Equally important is the crucial role of bats in various ecosystem services. This necessitates a multidisciplinary One Health approach to close knowledge gaps and ensure the development of responsible mitigation strategies to not only minimize risk of infection but also ensure conservation of the species.
Representative Bureaucracy, Distributional Equity, and Environmental Justice
Authors: Liang Jiaqi , Park Sanghee , Zhao Tianshu 
Published: February 2020

AbstractThis article explores the role of bureaucratic representation and distributional equity in the implementation of environmental policy, which has been shaped by the politics of identity, administrative discretion, and a contested discourse on the redistribution of public resources. The authors examine whether minority bureaucratic representation fosters policy outputs for race‐related disadvantaged communities and whether the behavior of public administrators reflects distributional equity. Linking representative bureaucracy to environmental justice, this research contributes to the understanding of social equity in public administration and sheds light on the relationship between bureaucratic representation and democratic values. Analyzing a nationwide, block‐group‐level data set, the authors find that a more racially representative workforce in the U.S. Environmental Protection Agency promotes the agency's enforcement actions in communities that have large local‐national disparities in minority populations and severe policy problems. The size of the bureaucratic representation effect is larger for neighborhoods that are overburdened with race‐related social vulnerability.Evidence for Practice

Public administrators can play a critical role in representing the general public, particularly those who have historically been marginalized and underserved, and acting in their interests.
Non‐service‐oriented regulatory agencies have taken equity into account in the process of implementing policies and serving socially vulnerable clients.
Public administrators need to be cognizant of the degree of preexisting inequity in local communities, acquire adequate information to ascertain the equity point, and devise public policies and programs to achieve various democratic values.
It is important to recruit more underrepresented and historically disadvantaged members of society into the public workforce.
Effect of dietary supplementation of whole flaxseed on sperm traits and sperm fatty acid profile in aged broiler breeder roosters
Authors: Abbaspour Behnam , Sharifi Seyed Davood , Ghazanfari Shokoufe , Mohammadi‐Sangcheshmeh Abdollah , Honarbakhsh Shirin 
Published: February 2020

AbstractThe objective of this study was to evaluate the effect of dietary supplementation of whole flaxseed on sperm traits and sperm fatty acid profile in aged broiler breeder roosters. Twelve Ross 308 broiler breeder roosters (age: 52 weeks; weight: 4,900 ± 210 g) haphazardly allotted to three dietary treatments (each treatment contained four replicates and one bird in each replicate) for six weeks. Treatments were different levels of flaxseed (0% flaxseed [GFL0], 2% flaxseed [GFL2] and 4% flaxseed [GFL4]). The feed intake quadratically decreased (p < .05) with increasing whole flaxseed levels for the period (58 to 60 weeks). Sperm traits (semen volume and sperm concentration, sperm total and forward motility, sperm viability and morphology, sperm plasma membrane functionality) were evaluated every two weeks (four times), and sperm fatty acid profile was assessed at the end of the experiment. Semen volume, sperm concentration and sperm morphology were not affected by treatments. On week 60, GFL2 group showed a significantly lower percentage of total and progressive sperm motility and sperm membrane functionality in comparison with the control and GFL4 groups. Also, sperm viability was lower in GFL2 group compared with other groups on week 58 (p < .05). In terms of sperm fatty acid profile, GFL2 group significantly reduced the percentage of linoleic acid (C18:2 [n‐6]) in comparison with other groups. However, any of the other fatty acids were not affected by dietary flaxseed. In conclusion, dietary supplementation of whole flaxseed could not improve the quality of aged broiler breeder roosters' sperm in this study, nor it could alter the sperm fatty acid profile; thus, it seems necessary to use some antioxidants such as vitamin E in the diet of aged broiler breeder roosters, when supplementing the diets with oils or oilseeds such as flaxseed.
Distributed Actuation and Control of a Morphing Tensegrity Structure
Authors: Lai Guanyu , Plummer Andrew , Cleaver David 
Published: February 2020

Abstract
Structures and actuation systems need to be closely integrated together in the future to create faster, more efficient, lightweight dynamic machines. Such actuated structures would be used for morphing aircraft wings, lightweight actuated space structures, or in robotics. This approach requires actuators to be distributed through the structure. A tensegrity structure is a very promising candidate for this future integration due to its potentially excellent stiffness and strength-to-weight ratio, and the inherent advantage of being a multi-element structure into which actuators can be embedded. This paper presents methods for analysis of the structure geometry, for closed-loop motion control, and includes experimental results for a structure actuated by lightweight pneumatic muscles. In a practical morphing tensegrity structure, it cannot be assumed that tension and compression members always meet at a point. Thus, a form-finding method has been developed to find stable geometries and determine stiffness properties for tensegrity structures with nodes of finite dimension. An antagonistic multi-axis control scheme has been developed for the shape position and motion control. In the experimental actuated tensegrity system presented the pneumatic muscles are controlled by on-off valves, for which a dead-band switching controller is designed based on a new stability criterion. The experimental system demonstrates accurate control of shape change while maintaining a desired level of internal preload in a stiff structure, showing considerable promise for future lightweight dynamic machines.
Exploring abnormal glucose metabolism in pregnancy among Australian Chinese migrants
Authors: Li Ling-Jun , Zhang Jun , Shub Alexis , Aris Izzuddin , Tan Kok Hian 
Published: February 2020

ObjectiveGestational diabetes mellitus (GDM) is a metabolic disorder of pregnancy that is increasingly prevalent among Chinese women. Few studies have examined whether the migration status of Chinese women contributes to the risks of developing GDM during pregnancy.Research design and methodsIn this observational, cross-sectional and hospital-based study, we examined the prevalence of GDM and glycemic levels at oral glucose tolerance test (OGTT) among 491 Australian Chinese migrants (n=491) and native Chinese (n=1000). We defined GDM using the International Association of Diabetes and Pregnancy Study Groups guidelines. We collected data on maternal age, body mass index (BMI) and gestational age (GA) at booking and GA at delivery from medical records. We used multiple logistic and linear regression models to calculate the OR of having GDM and mean differences in glycemic levels in Australian Chinese migrants, relative to native Chinese.ResultsAge-at-booking and BMI-at-booking adjusted GDM prevalence was significantly higher in Australian Chinese migrants than native Chinese (19.7% vs 14.6%; p=0.01). After adjusting for age, BMI at booking and GA at booking, fasting glucose levels were significantly lower (β −0.08 mmol/L; 95% CI −0.14 to 0.02), while 2-hour glucose levels were significantly higher (0.22 mmol/L; 0.02 to 0.43) in Australian Chinese immigrants than native Chinese.ConclusionsMigration status may be a marker for abnormal glucose metabolism during pregnancy among Australian Chinese migrants, possibly due to socio-economic disadvantages and lifestyle changes associated with migration.
Examining the diversity of ultra-processed food consumption and associated factors in Canadian adults
Authors: Seale Emily , Greene-Finestone Linda S. , de Groh Margaret 
Published: February 2020

Ultra-processed food (UPF) consumption is increasing globally at an unprecedented rate. We investigated UPF consumption among Canadian adults and associated sociodemographic and health-related factors. This study was a secondary analysis of the Foodbook study (2014–2015), which collected self-reported data on foods consumed by Canadians during a 7-day period. UPF diversity was assessed by summing the different types of UPFs consumed in the previous week to produce a diversity score. Descriptive statistics summarized UPF diversity among subgroups in Canada. Regression models identified significant associations between UPF diversity, body mass index (BMI), and sociodemographic variables. This study included 6062 participants, aged 18 years and older, representing 24.7 million Canadian adults. Almost all Canadian adults (99.0%) consumed UPFs at least once weekly. The most common UPFs consumed were chocolate, chips/pretzels, cold breakfast cereal, and fast foods. UPF diversity was greatest among men, young respondents, those with high income, and those with obesity. When controlling for potential confounders, UPF diversity for men and women was significantly associated with younger age and higher BMI; it was also associated with region for women. This study suggests UPF consumption in Canada varies across sociodemographic subgroups, but ultimately is pervasive. Further research examining potential health risks associated with UPF consumption is encouraged to inform Canadian interventions. Novelty: Almost all Canadians consume at least one type of ultra-processed food weekly. Nearly half or more Canadians consume chocolate, chips/pretzels, cold breakfast cereal, or fast food at least once weekly. Gender, age, and BMI are consistently associated with ultra-processed food diversity.
Broadband liquid sensing with a spoof plasmon transmission line
Authors: Li Peng , Huang Ming , Yang Jingjing , Yang Chengfu , Yang Meixia , Zhou Kefeng 
Published: February 2020

One of the most remarkable features of surface plasmon polaritons (SPPs) is their usefulness for sensing. In this paper, we introduce a spoof SPP sensor consisting of a transmission line with a rectangular groove array. We investigated its dispersion relation and verified the broadband transmission characteristics of its SPP mode. A sensing model with spoof SPPs has been developed and a prototype fabricated. Three analytes with different permittivity were introduced into the model and prototype — edible oil, glycerol, and water — and the results compared to those obtained with air. The results of simulation and measurement show that the sensor is extremely sensitive to the permittivity of a liquid. The results indicate that spoof SPP sensors have important potential applications in industrial processing, food safety, and environmental monitoring.
Different mechanisms for modulation of the initiation and steady-state of smooth pursuit eye movements
Authors: Behling Stuart , Lisberger Stephen G. 
Published: February 2020

Smooth pursuit eye movements are used by primates to track moving objects. They are initiated by sensory estimates of target speed represented in the middle temporal (MT) area of extrastriate visual cortex and then supported by motor feedback to maintain steady-state eye speed at target speed. Here, we show that reducing the coherence in a patch of dots for a tracking target degrades the eye speed both at the initiation of pursuit and during steady-state tracking, when eye speed reaches an asymptote well below target speed. The deficits are quantitatively different between the motor-supported steady-state of pursuit and the sensory-driven initiation of pursuit, suggesting separate mechanisms. The deficit in visually guided pursuit initiation could not explain the deficit in steady-state tracking. Pulses of target speed during steady-state tracking revealed lower sensitivities to image motion across the retina for lower values of dot coherence. However, sensitivity was not zero, implying that visual motion should still be driving eye velocity toward target velocity. When we changed dot coherence from 100% to lower values during accurate steady-state pursuit, we observed larger eye decelerations for lower coherences, as expected if motor feedback was reduced in gain. A simple pursuit model accounts for our data based on separate modulation of the strength of visual-motor transmission and motor feedback. We suggest that reduced dot coherence allows us to observe evidence for separate modulations of the gain of visual-motor transmission during pursuit initiation and of the motor corollary discharges that comprise eye velocity memory and support steady-state tracking. NEW & NOTEWORTHY We exploit low-coherence patches of dots to control the initiation and steady state of smooth pursuit eye movements and show that these two phases of movement are modulated separately by the reliability of visual motion signals. We conclude that the neural circuit for pursuit includes separate modulation of the strength of visual-motor transmission for movement initiation and of eye velocity positive feedback to support steady-state tracking.
Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade
Authors: Snook Jeremy P. , Soedel Ashleigh J. , Ekiz H. Atakan , O'Connell Ryan M. , Williams Matthew A. 
Published: February 2020

Abstract

The presence and activity of CD8+ T cells within the tumor microenvironment are essential for the control of tumor growth. Utilizing B16-F10 melanoma tumors that express altered peptide ligands of chicken ovalbumin, OVA257-264, we measured high- and low-affinity OVA-specific responses following adoptive transfer of OT-I CD8+ T cell into mice subsequently challenged with tumors. T-cell receptor (TCR) affinity positively correlated with the frequency of OT-I tumor-infiltrating lymphocytes (TIL). Differences in TCR affinity inversely corresponded to in vivo tumor growth rate. Blockade of the PD-1 and CTLA-4 checkpoints preferentially increased the frequency and antitumor function of TIL responding to high-affinity antigens, while failing to enhance the antitumor activity of low-affinity T cells. To determine whether lowering the TCR activation threshold could enhance the breadth and magnitude of the antitumor T-cell response, we inhibited Src homology region 2 domain–containing phosphatase 1 (SHP-1) in OT-I T cells prior to tumor antigen exposure. SHP-1 knockdown increased the cytokine-producing potential of high- and low-affinity T cells but failed to enhance control of tumor growth. In contrast, when SHP-1 knockdown of OT-I T cells was combined with immunotherapy, we observed a significant and long-lasting suppression of tumor growth mediated by low-affinity T cells. We conclude that lowering the TCR activation threshold by targeting SHP-1 expands the repertoire of T cells available to respond to conventional checkpoint blockade, leading to enhanced control of tumor growth.
Spatial Neuronal Integration Supports a Global Representation of Visual Numerosity in Primate Association Cortices
Authors: Viswanathan Pooja , Nieder Andreas 
Published: February 2020

Abstract
Our sense of number rests on the activity of neurons that are tuned to the number of items and show great invariance across display formats and modalities. Whether numerosity coding becomes abstracted from local spatial representations characteristic of visual input is not known. We mapped the visual receptive fields (RFs) of numerosity-selective neurons in the pFC and ventral intraparietal area in rhesus monkeys. We found numerosity selectivity in pFC and ventral intraparietal neurons irrespective of whether they exhibited an RF and independent of the location of their RFs. RFs were not predictive of the preference of numerosity-selective neurons. Furthermore, the presence and location of RFs had no impact on tuning width and quality of the numerosity-selective neurons. These findings show that neurons in frontal and parietal cortices integrate abstract visuospatial stimuli to give rise to global and spatially released number representations as required for number perception.
Presentation of BK polyomavirus–associated hemorrhagic cystitis after allogeneic hematopoietic cell transplantation
Authors: Imlay Hannah , Xie Hu , Leisenring Wendy M. , Duke Elizabeth R. , Kimball Louise E. , Huang Meei-Li , Pergam Steven A. , Hill Joshua A. , Jerome Keith R. , Milano Filippo , Nichols W. Garrett , Pang Phillip S. , Hirsch Hans H. , Limaye Ajit P. , Boeckh Michael 
Published: February 2020

Abstract
BK polyomavirus (BKPyV) has been associated with hemorrhagic cystitis (HC) after allogeneic hematopoietic cell transplantation (HCT), but the natural history of HC and factors associated with the clinical course are incompletely understood. We retrospectively analyzed allogeneic HCT patients transplanted from 2007-2017 who presented after platelet engraftment or after day 28 post-HCT with BKPyV-associated HC (BKPyV-HC), which was defined as a positive urine BKPyV PCR, ≥1 plasma BKPyV viral load result, and macroscopic hematuria (Bedi grade ≥2). Factors associated with resolution of macroscopic hematuria and resolution of all cystitis symptoms within 90 days after HC diagnosis were investigated in multivariable models. In 128 patients with BKPyV-HC, the median times from diagnosis to resolution of all symptoms, macroscopic hematuria, and urinary clots (present in 55% [71/128]) were 24 days (15-44), 17 days (10-30), and 14 days (5-26), respectively. Ninety percent of patients had BKPyV viremia at the onset of HC with a median viral load of 1850 copies/mL (interquartile range, 240-8550). In multivariable models, high plasma viral load (≥10 000 copies/mL) and cytopenias at the beginning of BKPyV-HC were significantly associated with longer macroscopic hematuria and cystitis symptoms. Use of cidofovir was not associated with shorter duration of illness. In conclusion, BKPyV-HC after allogeneic HCT is characterized by prolonged and severe symptoms and requires improved management strategies. High-grade viremia and cytopenias were associated with a longer duration of BKPyV-associated HC. Accurate descriptions of disease and factors associated with prolonged recovery will inform end points of future clinical trials.
Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation
Authors: Liu Peng , Miao Kang , Zhang Lei , Mou Yong , Xu Yongjian , Xiong Weining , Yu Jun , Wang Yi 
Published: February 2020

Abstract
Background
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by excessive fibroblast to myofibroblast differentiation with limited therapeutic options. Curdione, a sesquiterpene compound extracted from the essential oil of Curcuma aromatica Salisb, has anti-inflammatory and anti-tumor effects. However, the role of curdione in IPF is still unclear.

Methods
The effects of curdione were evaluated in a bleomycin (BLM)-induced pulmonary fibrosis mouse model. C57BL/6 mice were treated with BLM on day 0 by intratracheal injection and intraperitoneal administered curdione or vehicle. In vitro study, expression of fibrotic protein was examined and the transforming growth factor (TGF)-β-related signaling was evaluated in human pulmonary fibroblasts (HPFs) treated with curdione following TGF-β1 stimulation.

Results
Histological and immunofluorescent examination showed that curdione alleviated BLM-induced lung injury and fibrosis. Specifically, curdione significantly attenuated fibroblast to myofibroblast differentiation in the lung in BLM induced mice. Furthermore, curdione also decreased TGF-β1 induced fibroblast to myofibroblast differentiation in vitro, as evidenced by low expression of α-SMA, collagen 1 and fibronectin in a dose dependent manner. Mechanistically, curdione suppressed the phosphorylation of Smad3 following TGF-β1 treatment, thereby inhibiting fibroblast differentiation.

Conclusions
Overall, curdione exerted therapeutic effects against pulmonary fibrosis via attenuating fibroblast to myofibroblast differentiation. As curdione had been shown to be safe and well-tolerated in BLM-induced mouse model, curdione might be useful for developing novel therapeutics for IPF.