bluuebunny/crossref_metadata_2025_split huggingface dataset:
No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-α gene and susceptibility to prostate cancer: a comprehensive meta-analysis
Authors: Yin Lei , Yue Chuang , Jing Hongwei , Yu Hongyuan , Zuo Li , Liu Tao 
Published: April 2020

Abstract
Background
Inflammation is one of the factors associated with prostate cancer. The cytokine tumor necrosis factor-alpha (TNF-α) plays an important role in inflammation. Several studies have focused on the association between TNF-α polymorphisms and prostate cancer development. Our meta-analysis aimed to estimate the association between TNF-α rs1800629 (− 308 G/A), rs361525 (− 238 G/A) and rs1799724 polymorphisms and prostate cancer risk.

Methods
Eligible studies were identified from electronic databases (PubMed, Embase, Wanfang and CNKI) using keywords: TNF-α, polymorphism, prostate cancer, until Nov 15, 2019. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to determine the association from a quantitative point-of-view. Publication bias and sensitivity analysis were also applied to evaluate the power of current study. All statistical analyses were done with Stata 11.0 software.

Results
Twenty-two different articles were included (22 studies about rs1800629; 8 studies for rs361525 and 5 studies related to rs1799724). Overall, no significant association was found between rs1800629 and rs1799724 polymorphisms and the risk of prostate cancer in the whole (such as: OR = 1.03, 95% CI = 0.92–1.16, P = 0.580 in the allele for rs1800629; OR = 0.95, 95% CI = 0.84–1.07, P = 0.381 in the allele for rs1799724). The rs361525 polymorphism also had no association with prostate cancer in the cases (OR = 0.93, 95% CI = 0.66–1.32, P = 0.684 in the allele) and ethnicity subgroup. The stratified subgroup of genotype method, however, revealed that the rs361525 variant significantly decreased the risk of prostate cancer in the Others (OR = 0.65, 95% CI = 0.47–0.89, P = 0.008, A-allele vs G-allele) and PCR-RFLP (OR = 2.68, 95% CI = 1.00–7.20, P = 0.050, AG vs GG or AA+AG vs GG) methods.

Conclusions
In summary, the findings of the current meta-analysis indicate that the TNF-α rs1800629, rs361525 and rs1799724 polymorphisms are not correlated with prostate cancer development, although there were some pooled positive results. Further well-designed studies are necessary to form more precise conclusions.
Prevalence of class 1 integron in Escherichia coli isolated from animal sources in Iran: a systematic review and meta-analysis
Authors: Karimi Dehkordi Maryam , Halaji Mehrdad , Nouri Samereh 
Published: April 2020

Abstract
Background
Among the genetic elements, integrons may contribute to the widespread incidence and spreading of antibiotic resistance among Escherichia coli isolates. Accordingly, this review aims to investigate the prevalence of class 1 integron in E. coli isolated from animal sources in Iran.

Methods
This systematic literature search was performed from January 1, 2000 to the end of May 1, 2019.
Then, publications that met our inclusion criteria were selected for data extraction and analysis. Also, the quality of included studies was independently assessed by two researchers based on the Joanna Briggs Institute. Meta-analysis was performed by the Comprehensive Meta-Analysis (CMA) software using the random effects model, Cochran’s Q, and I2 tests. Publication bias was estimated by funnel plot and Egger’s linear regression test.

Results
Based on inclusion criteria, five studies were included to meta-analysis. From those studies, the pooled prevalence of integrons was 33% (95% CI, 23.8–43.7%) ranging from 23.8 to 52.4%. There was a significant heterogeneity among the 5 studies (χ2 = 11.73; p < 0.019; I2 = 65.91%). Additionally, Begg’s and Egger’s tests were performed to quantitatively evaluate the publication biases. According to the results of Begg’s test (z = 1.22, p = 0.22) and Egger’s test (t = 3.03, p = 0.056), a significant publication bias was not observed.

Conclusions
Our finding revealed the relatively high prevalence of class 1 integrons among E. coli isolates. Moreover, there was a significant heterogeneity among studies and subgroup analysis also showed that there was no difference about prevalence of class 1 integrons among different sample source.
Theoretical framework for predicting solute concentrations and solute-induced stresses in finite volumes with arbitrary elastic fields
Authors: Gu Yejun , El-Awady Jaafar A. 
Published: April 2020

AbstractA theoretical model for computing the interstitial solute concentration and the interstitial solute-induced stress field in a three-dimensional finite medium with any arbitrary elastic fields was developed. This model can be directly incorporated into two-dimensional or three-dimensional discrete dislocation dynamics simulations, continuum dislocation dynamics simulations, or crystal plasticity simulations. Using this model, it is shown that a nano-hydride can form in the tensile region below a dissociated edge dislocation at hydrogen concentration as low as χ0=5×10−5, and its formation induces a localized hydrogen elastic shielding effect that leads to a lower stacking fault width for the edge dislocation. Additionally, the model also predicts the segregation of hydrogen at Σ109(13 7 0)/33.4∘ symmetric tilt grain boundary dislocations. This segregation strongly alters the magnitude of the shear stresses at the grain boundary, which can subsequently alter dislocation-grain boundary interactions and dislocation slip transmissions across the grain boundary. Moreover, the model also predicts that the hydrogen concentration at a mode-I central crack tip increases with increasing external loading, higher intrinsic hydrogen concentration, and/or larger crack lengths. Finally, linearized approximate closed-form solutions for the solute concentration and the interstitial solute-induced stress field were also developed. These approximate solutions can effectively reduce the computation cost to assess the concentration and stress field in the presence of solutes. These approximate solutions are also shown to be a good approximation when the positions of interest are several nanometers away (i.e. long-ranged elastic interactions) from stress singularities (e.g. dislocation core and crack tip), for low solute concentrations, and/or at high temperatures.
Skin manifestations of malnutrition in HIV-positive meningitis patients
Authors: Amalakanti Sridhar 
Published: April 2020

Abstract
Background
HIV infection and meningitis are diseases which are known to precipitate malnutrition. Skin manifestations of malnutrition are easy to identify. We tried to describe the skin manifestations of malnutrition in HIV-positive patients with meningitis.

Setting
Patients included in the study were from a tertiary referral hospital in South India.

Methods
In a cross-sectional observational design, we studied 56 adult [> 14 years] HIV-seropositive patients with meningitis by clinical assessment of skin manifestations of malnutrition.

Results
Skin wasting (31.5%), hyperpigmentation of skin (22.2%) and skin ulceration (16.4%) were the chief skin manifestations of malnutrition in HIV-positive patients with meningitis.

Conclusions
Our study shows that certain cutaneous features of malnutrition like skin ulcers, skin wasting and hypo pigmentation are common in HIV patients with meningitis.
Endoscopic assisted microvascular decompression versus new antiepileptics and BOTOX in treatment of hemifacial spasm: a clinical trial
Authors: Morsy Moamen Mohamed , Foaud Wael Ahmed , Abu-Elenain Hisham Adel , Aly Mohammed Abbas 
Published: April 2020

Abstract
Introduction
Hemifacial spasm (HFS) is a chronic movement disorder characterized by twitching of muscles of facial expression which is innervated by the facial nerve. The condition is unilaterally, beginning in the orbicularis occuli, and later on progress to involve the perioral, platysma, and other muscles of facial expression. Endoscopic assisted microvascular decompression is considered the state of the art in hemi-facial spasm surgery. New antiepileptic have emerged with a new hope for good control with few side effects. Botulinum toxin is still a good option for some patients.

Methods
This study is a prospective study that was conducted on 30 patients with primary hemifacial spasm. Bilateral and secondary cases where excluded. All patients were subjected to proper pre-treatment assessment including; proper history taking, clinical examination, and proper radiological investigations (MRI, FISTA) when needed. They were divided into three groups according to treatment modality: group A where patient's general condition was unfit for surgical intervention, received oral medications (gabapentin or levetiracetam); group B included those patients unfit for surgical intervention and did not respond to oral therapy, received Botox injection; and group C underwent endoscopic assisted microvascular decompression. Follow-up period ranged from 6 to 24 months. Outcome of different treatment modalities were compared among different groups.

Results
Among group A patients, one patient showed excellent response to treatment (Gabapentin 1200 mg), three patients had good response, four patients had fair response, and three patients had poor response to treatment (one used levetiracetam, two used gabapentin). Overall success rate is 72.7%. Among group B patients, four patients enjoyed excellent response. Another four patients had good response, while three patients had fair response. Only one patient had poor response. Overall success rate was 83.3%. Among group C patients, five cases had excellent outcome and two cases had good outcome. Overall success rate is 100%.

Conclusion
Endoscopic assisted microvascular decompression offers the best chance to permanent cure with low complication rate. New antiepileptics (levetiracetam, gabapentin) provide a safe therapy for patients refusing surgical intervention. Botox is an attractive local therapy with reversible complications but with non-sustainable effect. From our results, we conclude that endoscopic assisted microvascular decompression is superior to either BOTOX or antiepiletics for the permanent cure of hemifacial spasm.
Asia–Gondwana connections indicated by Devonian fishes from Australia: palaeogeographic considerations
Authors: Young Gavin Charles , Lu Jing 
Published: April 2020

AbstractMiddle Palaeozoic vertebrate fossil occurrences are summarised for Australia, with reference to faunal connections between Asia and East Gondwana, as first indicated by fish distributions of Lower Devonian fossil sites. Major endemic groups discussed are pituriaspid (Australian) and galeaspid (Asian) agnathans, wuttagoonaspids (Australian) and antarctaspid (Antarctic, Australian, Asian) arthrodires, yunnanolepid and sinolepid antiarchs (South China, Indochina terrane, Australia), and early tetrapodomorphs (South China, Australia). More widespread groups that lived in shallow marine environments (lungfishes, buchanosteid arthrodires, antiarchBothriolepis) also show species groups shared between South China and East Gondwana. Exchange of continental facies fishes (e.g. tristichopterid tetrapodomorphs) may have been interrupted by marine transgression in the Frasnian, but were restored in the late Famennian with the appearance ofGrenfellaspisin eastern Australia, the only sinolepid antiarch known from outside Asia. The hypothesis of Gondwana dispersion and Asian accretion, to explain the collage of geological terranes forming modern east and southeast Asia, implies increasing dissimilarity with increasing age, but the Siluro-Devonian early vertebrate evidence is inconsistent with this. Previous cladistic analysis of Asian terranes predicted galeaspid agnathans on the Indochina terrane, and their subsequent discovery at Ly Hoa, Vietnam, confirms that Indochina and South China had come together across the Song Ma suture by Middle Devonian time.
Frequency of de novo atrial fibrillation in patients presenting with acute ischemic cerebrovascular stroke
Authors: Abdelnabi Mahmoud , Almaghraby Abdallah , Saleh Yehia , Özden Tok Özge , Kemaloğlu Öz Tuğba , Abdelkarim Ola , Badran Haitham 
Published: April 2020

AbstractBackgroundAtrial fibrillation (AF) affects millions of people worldwide and can remain undiagnosed for years. It is a major cause of cerebrovascular stroke (CVS); hence, early detection is extremely important in order to decrease the risk of CVS. We conducted a retrospective observational study looking into the prevalence of silent AF in 3299 patients admitted from January 2014 to December 2017 in a tertiary care stroke specialized center. Ischemic CVS was confirmed either by using multislice computed tomography (MSCT) or magnetic resonance imaging (MRI) of the brain. AF was diagnosed by electrocardiography (ECG) at the time of admission or during the hospital stay. Patients with a history of AF were excluded from the study.ResultsOf the 3299 patients admitted by acute ischemic CVS, 707 (21.43%) had a history of AF and thus were excluded from the study. Of the remaining 2592 patients eligible for the study, 1666 (64.27%) were males with a mean age of 56.06 years (± 16.01). A total of 2313 (89.24%) patients remained in sinus rhythm throughout the hospital stay, 211 (8.14%) patients were in AF on admission, and 68 (2.62 %) patients developed AF during their hospital stay. The total number of newly diagnosed patients with AF was 279 (10.76%).ConclusionThe prevalence of de novo atrial fibrillation in patients presented with acute cerebrovascular stroke is high. The implementation of good screening programs can significantly reduce the risk of disabilities and morbidities.
Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance
Authors: Saez Trinidad M. M. , Fernandez Bessone Iván , Rodriguez María S. , Alloatti Matías , Otero María G. , Cromberg Lucas E. , Pozo Devoto Victorio M. , Oubiña Gonzalo , Sosa Lucas , Buffone Mariano G. , Gelman Diego M. , Falzone Tomás L. 
Published: April 2020

ABSTRACT
Endocannabinoids (eCB) modulate growth cone dynamics and axonal pathfinding through the stimulation of cannabinoid type-1 receptors (CB1R), the function of which depends on their delivery and precise presentation at the growth cone surface. However, the mechanism involved in the axonal transport of CB1R and its transport role in eCB signaling remains elusive. As mutations in the kinesin-1 molecular motor have been identified in patients with abnormal cortical development and impaired white matter integrity, we studied the defects in axonal pathfinding and fasciculation in mice lacking the kinesin light chain 1 (Klc1−/−) subunit of kinesin-1. Reduced levels of CB1R were found in corticofugal projections and axonal growth cones in Klc1−/− mice. By live-cell imaging of CB1R-eGFP we characterized the axonal transport of CB1R vesicles and described the defects in transport that arise after KLC1 deletion. Cofilin activation, which is necessary for actin dynamics during growth cone remodeling, is impaired in the Klc1−/− cerebral cortex. In addition, Klc1−/− neurons showed expanded growth cones that were unresponsive to CB1R-induced axonal elongation. Together, our data reveal the relevance of kinesin-1 in CB1R axonal transport and in eCB signaling during brain wiring.
Mitochondrial–nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites
Authors: Martinez-Guzman Osiris , Willoughby Mathilda M. , Saini Arushi , Dietz Jonathan V. , Bohovych Iryna , Medlock Amy E. , Khalimonchuk Oleh , Reddi Amit R. 
Published: April 2020

ABSTRACT
Heme is a cofactor and signaling molecule that is essential for much of aerobic life. All heme-dependent processes in eukaryotes require that heme is trafficked from its site of synthesis in the mitochondria to hemoproteins located throughout the cell. However, the mechanisms governing the mobilization of heme out of the mitochondria, and the spatio-temporal dynamics of these processes, are poorly understood. Here, using genetically encoded fluorescent heme sensors, we developed a live-cell assay to monitor heme distribution dynamics between the mitochondrial inner membrane, where heme is synthesized, and the mitochondrial matrix, cytosol and nucleus. Surprisingly, heme trafficking to the nucleus is ∼25% faster than to the cytosol or mitochondrial matrix, which have nearly identical heme trafficking dynamics, potentially supporting a role for heme as a mitochondrial–nuclear retrograde signal. Moreover, we discovered that the heme synthetic enzyme 5-aminolevulinic acid synthase (ALAS, also known as Hem1 in yeast), and GTPases in control of the mitochondrial dynamics machinery (Mgm1 and Dnm1) and ER contact sites (Gem1), regulate the flow of heme between the mitochondria and nucleus. Overall, our results indicate that there are parallel pathways for the distribution of bioavailable heme.
This article has an associated First Person interview with the first author of the paper.
DE-cadherin and Myosin II balance regulates furrow length for onset of polygon shape in syncytial Drosophila embryos
Authors: Dey Bipasha , Rikhy Richa 
Published: April 2020

ABSTRACT
Cell shape morphogenesis, from spherical to polygonal, occurs in epithelial cell formation in metazoan embryogenesis. In syncytial Drosophila embryos, the plasma membrane incompletely surrounds each nucleus and is organized as a polygonal epithelial-like array. Each cortical syncytial division cycle shows a circular to polygonal plasma membrane transition along with furrow extension between adjacent nuclei from interphase to metaphase. In this study, we assess the relative contribution of DE-cadherin (also known as Shotgun) and Myosin II (comprising Zipper and Spaghetti squash in flies) at the furrow to polygonal shape transition. We show that polygonality initiates during each cortical syncytial division cycle when the furrow extends from 4.75 to 5.75 μm. Polygon plasma membrane organization correlates with increased junctional tension, increased DE-cadherin and decreased Myosin II mobility. DE-cadherin regulates furrow length and polygonality. Decreased Myosin II activity allows for polygonality to occur at a lower length than controls. Increased Myosin II activity leads to loss of lateral furrow formation and complete disruption of the polygonal shape transition. Our studies show that DE-cadherin–Myosin II balance regulates an optimal lateral membrane length during each syncytial cycle for polygonal shape transition.
This article has an associated First Person interview with the first author of the paper.
Canonical nucleators are dispensable for stress granule assembly in Drosophila intestinal progenitors
Authors: Buddika Kasun , Ariyapala Ishara S. , Hazuga Mary A. , Riffert Derek , Sokol Nicholas S. 
Published: April 2020

ABSTRACT
Stressed cells downregulate translation initiation and assemble membrane-less foci termed stress granules (SGs). Although SGs have been extensively characterized in cultured cells, the existence of such structures in stressed adult stem cell pools remains poorly characterized. Here, we report that the Drosophila orthologs of the mammalian SG components AGO1, ATX2, CAPRIN, eIF4E, FMRP, G3BP, LIN-28, PABP and TIAR are enriched in adult fly intestinal progenitor cells, where they accumulate in small cytoplasmic messenger ribonucleoprotein complexes (mRNPs). Treatment with sodium arsenite or rapamycin reorganized these mRNPs into large cytoplasmic granules. Formation of these intestinal progenitor stress granules (IPSGs) depended on polysome disassembly, led to translational downregulation and was reversible. Although the canonical SG nucleators ATX2 and G3BP were sufficient for IPSG formation in the absence of stress, neither of them, nor TIAR, either individually or collectively, were required for stress-induced IPSG formation. This work therefore finds that IPSGs do not assemble via a canonical mechanism, raising the possibility that other stem cell populations employ a similar stress-response mechanism.
Ubc13–Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting
Authors: Renz Christian , Albanèse Véronique , Tröster Vera , Albert Thomas K. , Santt Olivier , Jacobs Susan C. , Khmelinskii Anton , Léon Sébastien , Ulrich Helle D. 
Published: April 2020

ABSTRACT
Polyubiquitin chains linked via lysine (K) 63 play an important role in endocytosis and membrane trafficking. Their primary source is the ubiquitin protein ligase (E3) Rsp5/NEDD4, which acts as a key regulator of membrane protein sorting. The heterodimeric ubiquitin-conjugating enzyme (E2), Ubc13–Mms2, catalyses K63-specific polyubiquitylation in genome maintenance and inflammatory signalling. In budding yeast, the only E3 proteins known to cooperate with Ubc13–Mms2 so far is a nuclear RING finger protein, Rad5, involved in the replication of damaged DNA. Here, we report a contribution of Ubc13–Mms2 to the sorting of membrane proteins to the yeast vacuole via the multivesicular body (MVB) pathway. In this context, Ubc13–Mms2 cooperates with Pib1, a FYVE-RING finger protein associated with internal membranes. Moreover, we identified a family of membrane-associated FYVE-(type)-RING finger proteins as cognate E3 proteins for Ubc13–Mms2 in several species, and genetic analysis indicates that the contribution of Ubc13–Mms2 to membrane trafficking in budding yeast goes beyond its cooperation with Pib1. Thus, our results widely implicate Ubc13–Mms2 as an Rsp5-independent source of K63-linked polyubiquitin chains in the regulation of membrane protein sorting.
This article has an associated First Person interview with the first author of the paper.
Owning, Using, and Renting: Some Simple Economics of the “Sharing Economy”
Authors: Filippas Apostolos , Horton John J. , Zeckhauser Richard J. 
Published: April 2020

New Internet-based “sharing-economy” markets enable consumer-owners to rent out their durable goods to nonowners. We model such markets and explore their equilibria both in the short run, in which ownership decisions are fixed, and in the long run, in which ownership decisions can be changed. We find that sharing-economy markets always expand consumption and increase surplus, but may increase or decrease ownership. Regardless, ownership is decoupled from individual preferences in the long run, as the rental rates and the purchase prices of goods become equal. If there are costs of bringing unused capacity to the market, they are partially passed through, creating a bias toward ownership. To test our theoretical work empirically, we conduct a survey of consumers, finding broad support for our modeling assumptions. The survey also allows us to offer a partial decomposition of the bring-to-market costs, based on attributes that make a good more or less amenable to being shared. This paper was accepted by Joshua Gans, business strategy.