bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling infectious viral diseases in swine populations: a state of the art
Authors: Andraud M. , Rose N. 
Published: August 2020

AbstractMathematical modelling is nowadays a pivotal tool for infectious diseases studies, completing regular biological investigations. The rapid growth of computer technology allowed for development of computational tools to address biological issues that could not be unravelled in the past. The global understanding of viral disease dynamics requires to account for all interactions at all levels, from within-host to between-herd, to have all the keys for development of control measures. A literature review was performed to disentangle modelling frameworks according to their major objectives and methodologies. One hundred and seventeen articles published between 1994 and 2020 were found to meet our inclusion criteria, which were defined to target papers representative of studies dealing with models of viral infection dynamics in pigs. A first descriptive analysis, using bibliometric indexes, permitted to identify keywords strongly related to the study scopes. Modelling studies were focused on particular infectious agents, with a shared objective: to better understand the viral dynamics for appropriate control measure adaptation. In a second step, selected papers were analysed to disentangle the modelling structures according to the objectives of the studies. The system representation was highly dependent on the nature of the pathogens. Enzootic viruses, such as swine influenza or porcine reproductive and respiratory syndrome, were generally investigated at the herd scale to analyse the impact of husbandry practices and prophylactic measures on infection dynamics. Epizootic agents (classical swine fever, foot-and-mouth disease or African swine fever viruses) were mostly studied using spatio-temporal simulation tools, to investigate the efficiency of surveillance and control protocols, which are predetermined for regulated diseases. A huge effort was made on model parameterization through the development of specific studies and methodologies insuring the robustness of parameter values to feed simulation tools.Integrative modelling frameworks, from within-host to spatio-temporal models, is clearly on the way. This would allow to capture the complexity of individual biological variabilities and to assess their consequences on the whole system at the population level. This would offer the opportunity to test and evaluate in silico the efficiency of possible control measures targeting specific epidemiological units, from hosts to herds, either individually or through their contact networks. Such decision support tools represent a strength for stakeholders to help mitigating infectious diseases dynamics and limiting economic consequences.
A web-based educational intervention to implement trauma-informed care in a paediatric healthcare setting: protocol for a feasibility study using pre-post mixed methods design
Authors: Simons Megan , De Young Alexandra , McPhail Steven M. , Harvey Gillian , Kenardy Justin , Kularatna Sanjeewa , Kimble Roy , Tyack Zephanie 
Published: August 2020

AbstractBackgroundAdoption of responsive trauma-informed practices by staff in hospital-based paediatric care may help mitigate downstream costs associated with treatment delivery due to reduced pain and distress for children and care providers, improved health-related quality of life and increased satisfaction with care. A web-based education intervention (termed Responsive CARE) was developed to build self-efficacy of staff in a paediatric medical setting. This protocol paper describes a feasibility study (including preliminary effectiveness) of the implementation of Responsive CARE in a tertiary, outpatient burn clinical setting.MethodsA pre-post, mixed methods design will be employed. Children and caregivers attending hospital for change of burn wound dressings or burn scar management during the 3-month control or 3-month intervention period will be eligible, with follow-up to 6-months post-baseline. All children and caregiver/s will receive “standard care” including burn interventions focused on wound healing, scar management, itch management (both pharmacological and non-pharmacological), counselling, age-appropriate procedural support and burn rehabilitation. Health professional participants will be those involved in the management of children with burns during the study period or their senior managers. Health professional participants who attend a weekly educational clinical meeting will be invited to complete the intervention during a 1-month timeframe between the control and intervention period (or upon their commencement in burn outpatients during the intervention period) using an individualised log-in process. A purposive sample of caregivers and health professionals will be sought for participation in semi-structured interviews. Qualitative data will be analysed using Framework analysis. Feasibility will be evaluated via interviews, digital records of intervention usage and technical assistance logs. The primary outcome measures of effectiveness (pain, itch and distress) will be measured using self-report or behavioural observation. Quantitative data will primarily be analysed descriptively and using generalised linear models.DiscussionThis study will provide insights into factors that impact upon the feasibility of a web-based trauma-informed care education intervention in a clinical practice setting. This knowledge may support other education approaches within healthcare settings related to improving and supporting patients to reduce the risk of healthcare interactions that result in paediatric medical traumatic stress.
Continuous erector spinae plane block for analgesia of sternum closure using a latissimus dorsi muscle flap for mediastinitis after coronary artery bypass grafting: a case report
Authors: Yamane Yu , Kosaka Masayuki , Akiizumi Haruki , Kuroda Mitsuo 
Published: August 2020

Abstract
Background
Erector spinae plane block (ESPB) is useful for providing analgesia after thoracic surgery. Previous reports show that ESPB is safely performed in patients receiving antithrombotic drugs. We effectively performed continuous ESPB in a patient receiving aspirin after coronary artery bypass grafting.

Case presentation
A 62-year-old man with mediastinitis was scheduled for sternum closure using a latissimus dorsi muscle flap. He had gone coronary artery bypass grafting and was taking aspirin. After induction of general anesthesia and tracheal intubation, a catheter was inserted for ESPB from the T6 level under ultrasound monitoring and infusion of ropivacaine was started. Tracheal tube was removed in the operating room, cold sense was absent between T2–8, and analgesia was between T3–T8 after uneventful surgery. There were no complications associated with ESPB postoperatively.

Conclusion
Continuous ESPB was a safe and useful analgesic method in a case undergoing sternum closure using a latissimus dorsi muscle flap.
Anesthetic management using a combination of anterior quadratus lumborum block and erector spinae plane block for robot-assisted partial nephrectomy: two case reports
Authors: Tanaka Nobuhiro , Kitazawa Takuzo , Mitani Saki , Suzuka Takanori , Kadoya Yuma , Kawaguchi Masahiko 
Published: August 2020

Abstract
Background
There has been increasing attention regarding quadratus lumborum block (QLB) and erector spinae plane block (ESPB) as effective truncal blocks. There have been reports of combined QLB and ESPB usage in hip surgery resulting in a symbiotic increase in effectiveness. However, there have been no reports regarding robot-assisted partial nephrectomy (RAPN), which requires multiple port holes ranging from near the xiphoid process to below the umbilicus. We hypothesized that the combined use of QLB and ESPB was an option for anesthesia and analgesia during RAPN.

Case presentation
Anterior QLB and ESPB were applied to two patients undergoing scheduled RAPN. With intravenous patient-controlled analgesia, the post-surgery numerical rating scale scores were < 3/10 at rest and < 5/10 upon movement, throughout the perioperative time.

Conclusions
The combination of QLB and ESPB could be an option for the postoperative analgesia in RAPN.
Neonatal and infantile appendicitis still confuses minds: report of two cases
Authors: Okumuş Mustafa , Zübarioğlu Adil Umut 
Published: August 2020

Abstract
Background
Acute appendicitis is extremely rare in the neonatal and infantile periods. The number of cases published in the last century is just over 100. Mortality and morbidity are still high due to diagnostic problems because there are no specific clinical features and reliable investigation for the diagnosis. Herein, we present two patients to remind physicians that the diagnosis of neonatal and infantile appendicitis should always be kept in mind.

Case presentations
A 30 3/7-week-old 740-g newborn girl was delivered by cesarean section because of preeclampsia. The newborn was followed in the neonatal intensive care unit and fed with an orogastric catheter. An abdominal distention developed on the 18th day of her life. While following up with a preliminary diagnosis of necrotizing enterocolitis, she was operated on the 4th day due to abdominal free air seen on X-ray. A perforated appendicitis was detected in the abdominal exploration and formal appendectomy was performed. Histology demonstrated marked transmural inflammation and necrosis at the perforated site and there was no evidence of Hirchsprung’s disease. The patient was started on breast milk on the third postoperative day and discharged home on day 98.
A 3.5-month-old boy was admitted to our clinic because of abdominal distention, discomfort, and constipation which had been ongoing for 4 days. He was followed up as an outpatient basis for 4 days in another center with the diagnosis of infantile colic. An increase in echogenicity due to intense inflammation was observed in mesenteric plans using USG in the right lower quadrant of the abdomen. Following preoperative preparations, the patient underwent abdominal exploration and appendectomy. He had an uneventful recovery and pathologic examination demonstrated a necrotizing appendicitis with perforation. He was discharged on the fourth postoperative day without any problems.

Conclusion
It is a fact that acute appendicitis in neonates and infants may not be diagnosed easily and quickly as in older children because there are no specific clinical features and reliable investigation for the diagnosis. Delay in diagnosis and treatment often results in appendicular perforation and peritonitis. The main safeguard against mortality and morbidity remains a high index of suspicion.
Mutation Rates in Cancer Susceptibility Genes in Patients With Breast Cancer With Multiple Primary Cancers
Authors: Maxwell Kara N. , Wenz Brandon M. , Kulkarni Abha , Wubbenhorst Bradley , D’Andrea Kurt , Weathers Benita , Goodman Noah , Vijai Joseph , Lilyquist Jenna , Hart Steven N. , Slavin Thomas P. , Schrader Kasmintan A. , Ravichandran Vignesh , Thomas Tinu , Hu Chunling , Robson Mark E. , Peterlongo Paolo , Bonanni Bernardo , Ford James M. , Garber Judy E. , Neuhausen Susan L. , Shah Payal D. , Bradbury Angela R. , DeMichele Angela M. , Offit Kenneth , Weitzel Jeffrey N. , Couch Fergus J. , Domchek Susan M. , Nathanson Katherine L. 
Published: August 2020

PURPOSE Women with breast cancer have a 4%-16% lifetime risk of a second primary cancer. Whether mutations in genes other than BRCA1/2 are enriched in patients with breast and another primary cancer over those with a single breast cancer (S-BC) is unknown. PATIENTS AND METHODS We identified pathogenic germline mutations in 17 cancer susceptibility genes in patients with BRCA1/2-negative breast cancer in 2 different cohorts: cohort 1, high-risk breast cancer program (multiple primary breast cancer [MP-BC], n = 551; S-BC, n = 449) and cohort 2, familial breast cancer research study (MP-BC, n = 340; S-BC, n = 1,464). Mutation rates in these 2 cohorts were compared with a control data set (Exome Aggregation Consortium [ExAC]). RESULTS Overall, pathogenic mutation rates for autosomal, dominantly inherited genes were higher in patients with MP-BC versus S-BC in both cohorts (8.5% v 4.9% [ P = .02] and 7.1% v 4.2% [ P = .03]). There were differences in individual gene mutation rates between cohorts. In both cohorts, younger age at first breast cancer was associated with higher mutation rates; the age of non–breast cancers was unrelated to mutation rate. TP53 and MSH6 mutations were significantly enriched in patients with MP-BC but not S-BC, whereas ATM and PALB2 mutations were significantly enriched in both groups compared with ExAC. CONCLUSION Mutation rates are at least 7% in all patients with BRCA1/2 mutation–negative MP-BC, regardless of age at diagnosis of breast cancer, with mutation rates up to 25% in patients with a first breast cancer diagnosed at age < 30 years. Our results suggest that all patients with breast cancer with a second primary cancer, regardless of age of onset, should undergo multigene panel testing.
Targeting DNA Methylation Depletes Uterine Leiomyoma Stem Cell–enriched Population by Stimulating Their Differentiation
Authors: Liu Shimeng , Yin Ping , Xu Jingting , Dotts Ariel J , Kujawa Stacy A , Coon V John S , Zhao Hong , Shilatifard Ali , Dai Yang , Bulun Serdar E 
Published: August 2020

AbstractUterine leiomyoma (LM) is the most common tumor in women and can cause severe morbidity. Leiomyoma growth requires the maintenance and proliferation of a stem cell population. Dysregulated deoxyribonucleic acid (DNA) methylation has been reported in LM, but its role in LM stem cell regulation remains unclear. Here, we fluorescence-activated cell sorting (FACS)-sorted cells from human LM tissues into 3 populations: LM stem cell–like cells (LSC, 5%), LM intermediate cells (LIC, 7%), and differentiated LM cells (LDC, 88%), and we analyzed the transcriptome and epigenetic landscape of LM cells at different differentiation stages. Leiomyoma stem cell–like cells harbored a unique methylome, with 8862 differentially methylated regions compared to LIC and 9444 compared to LDC, most of which were hypermethylated. Consistent with global hypermethylation, transcript levels of TET1 and TET3 methylcytosine dioxygenases were lower in LSC. Integrative analyses revealed an inverse relationship between methylation and gene expression changes during LSC differentiation. In LSC, hypermethylation suppressed the genes important for myometrium- and LM-associated functions, including muscle contraction and hormone action, to maintain stemness. The hypomethylating drug, 5′-Aza, stimulated LSC differentiation, depleting the stem cell population and inhibiting tumor initiation. Our data suggest that DNA methylation maintains the pool of LSC, which is critical for the regeneration of LM tumors.
Design of Supramolecular Sensors and Their Applications to Optical Chips and Organic Devices
Authors: Minami Tsuyoshi 
Published: August 2020

Abstract
In nature, molecular recognition is crucial to induce functions as living systems. Bioinspired molecular recognition chemistry has been intensively studied for more than half a century since the discovery of crown ethers. Chemical sensors are a concrete representative example of the application of artificial molecular recognition materials. The sensors have the ability to visualize the recognition phenomena and provide quantitative information on an analyte. However, developing chemical sensors that fully meet the requirements for practical application is still challenging. To this end, the author has focused on a cross-hierarchical and comprehensive development of chemical sensors based on molecular recognition chemistry and supramolecular chemistry. Through the efforts with bottom-up and top-down approaches, the author has contributed to the progress of practical supramolecular analytical chemistry which allows identification of target chemical species in real samples, and realization of sensor devices for on-site detection. This account summarizes the author’s recent achievements for chemical sensors including the design of artificial receptors, optical chemosensor arrays, and organic field-effect transistors.
Perceived usefulness of receiving a potential smoking cessation intervention via mobile phones among smokers in Indonesia
Authors: Wibowo Mochammad Fadjar , Kumar Anil A. , Sumarsono Surahyo , Rodrigues Rashmi 
Published: August 2020

Background:The use of technology to support healthcare in Indonesia holds new promise in light of decreasing costs of owning mobile devices and ease of access to internet. However, it is necessary to assess end-user perceptions regarding mobile health interventions prior to its implementation. This would throw light on the acceptability of mobile phone communication in bringing about behavioral changes among the target Indonesian population. The aim of this study was to explore the perceived usefulness of receiving a potential smoking cessation intervention via mobile phones.Methods:This is an exploratory cross-sectional study involving current and former adult tobacco smokers residing in Indonesia. Online advertisement and snowballing were used to recruit respondents. Data was collected using a web-based survey over a period of 4 weeks. Those willing to participate signed an online consent and were subsequently directed to the online questionnaire that obtained demographics, tobacco usage patterns, perceived usefulness of a mobile phone smoking cessation application and its design.Results:A total of 161 people who smoked tobacco responded to the online survey. The mean age of the participants was 29.4. Of the 123 respondents, 102 were men. Prior experience with using a mobile phone for health communication (OR 3.6,P=0.014) and those willing to quit smoking (OR 5.1,P=0.043) were likely to perceive a mobile phone smoking cessation intervention as useful. A smartphone application was preferred over text messages, media messages or interactive voice response technology. Content consisting of motivational messages highlighting the methods and benefits of quitting smoking were requested.Conclusion:People who smoke in Indonesia perceived receiving a potential smoking cessation intervention via mobile phones as useful. A multi-component, personalized smartphone application was the desired intervention technique. Such an intervention developed and implemented within a public health program could help address the tobacco epidemic in Indonesia.
Perfil dos usuários e padrão de utilização das Academias ao Ar Livre de Uberaba, Minas Gerais
Authors: Silva Debora Bernardo da , Tribess Sheilla , Papini Camila Bosquiero 
Published: August 2020

O objetivo foi analisar o perfil, nível de atividade física dos usuários e o padrão de uso das Academias ao Ar Livre (AAL) de Uberaba, Minas Gerais, Brasil. A coleta de dados foi realizada por meio de entrevista “in loco” com usuários de nove AAL. Foram entrevistados 148 usuários. Os usuários das AAL de Uberaba, Minas Gerais são na maioria mulher, adulto, casado, com ensino médio completo, percebem a saúde como boa e são ativos fisicamente. A proporção de usuários com renda até 2 salários mínimos foi de 53,4%. A maioria frequenta o espaço há mais de 1 mês, utiliza a AAL durante os dias de semana, mais de 3 vezes na semana com duração superior a 30 minutos. Os usuários consideram o local acessível, próximo à sua residência, e realizam deslocamento até o local caminhando. A grande maioria percebe a AAL como local seguro (93,9%), embora em três AAL não foram observados usuários nos dias da coleta. A maioria dos usuários não vai acompanhado, mas às vezes encontra pessoas que conhece e não possui acompanhamento de um profissional de educação física. Esses resultados devem ser considerados pelos gestores do município com a finalidade de promover maior utilização das AAL nos finais de semana e maior utilização de homens, jovens adultos e idosos e indivíduos de menor escolaridade.
Högselius, Per. Energy and Geopolitics. 1ª ed, New York: Routledge, 2019, 202p. ISBN: 978-1-315-17740-3
Authors: Ziebell de Oliveira Guilherme 
Published: August 2020

A obra resenhada discute a geopolítica da energia a partir de uma perspectiva neoliberal institucionalista, propondo uma análise que ressalta o papel dos recursos energéticos como propulsores da cooperação, e não apenas como ferramentas de poder e disputa entre os atores internacionais.Palavras-chave: Geopolítica; Energia; Cooperação.ABSTRACTThe reviewed work discusses the energy geopolitics from a neoliberal institutional perspective. It presents an analysis that highlights the role of energy resources as drivers of cooperation and not just as sources of power and dispute between international actorsKeywords: Geopolitics; Energy; Cooperation. Recebido em: 30 mar. 2020 | Aceito em: 28 jul. 2020.
The Art of Disney Costuming: Heroes, Villains, and Spaces Between, Jeff Kurtti and the Staff of the Walt Disney Archives (2019)
Authors: Healy Marley 
Published: August 2020

Review of: The Art of Disney Costuming: Heroes, Villains, and Spaces Between, Jeff Kurtti and the Staff of the Walt Disney Archives (2019)
Glendale, CA: Disney Editions, 176 pp.,
ISBN 978-1-48474-122-1, h/bk, $45
Rapid Resolution of Vulvar Crohn's Disease With Ustekinumab
Authors: Stoleru Gianna , Robbins Gordon , Papadimitriou John C. , Wong Uni 
Published: August 2020

ABSTRACT
In the evaluation of patients with inflammatory bowel disease, assessment of extraintestinal manifestations of disease is integral to clinical management. The patient described in this case is a 24-year-old woman with a history of inflammatory colonic Crohn's disease (CD) who presented to the hospital with one week of vaginal pain and swelling. Initial assessment focused on infectious etiologies, though final diagnosis of vulvar CD was made on biopsy. Clinical course and treatment of vulvar CD are poorly defined in existing literature. This case highlights the multidisciplinary management of inflammatory bowel disease patients and successful treatment of a rare extraintestinal manifestation with anti-interleukin 12/23 therapy.