bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated proteomic and metabolomic analysis to study the effects of spaceflight on Candida albicans
Authors: Wang Jiaping , Liu Yu , Zhao Guangxian , Gao Jianyi , Liu Junlian , Wu Xiaorui , Xu Chong , Li Yongzhi 
Published: December 2019

Abstract
Background: Candida albicans is an opportunistic pathogenic yeast, which could become pathogenic in various stressful environmental factors including the spaceflight environment. In this study, we aim to explore the phenotypic changes and possible mechanisms of Candida albicans after exposure to spaceflight conditions. Results: The effect of Candida albicans after carried on the "SJ-10" satellite for 12 days was evaluated by proliferation, morphology, environmental resistance and virulence experiment. The result showed that the proliferation rate, biofilm formation, antioxidant capacity, cytotoxicity and filamentous morphology of Candida albicans were increased in the spaceflight group compared to the control group. Proteomics and metabolomics technologies were used to analyze the profiles of proteins and metabolites in Candida albicans under spaceflight conditions. Proteomic analysis identified 548 up-regulated proteins involved in ribosome, DNA replication, base excision repair and sulfur metabolism in the spaceflight group. And 332 down-regulated proteins related to metabolic processes were observed. The metabolomic analysis found 5 differentially expressed metabolites. The combined analysis of proteomic and metabolomic revealed the accumulation of cysteine and methionine in Candida albicans after spaceflight. Conclusions: Mechanisms that could explain the results in the phenotypic experiment of Candida albicans were found through proteomic and metabolomic analysis. And our data provide an important basis for the assessment of the risk that Candida albicans could cause under spaceflight environment.
miR-200c inhibits the invasive activity of primary adamantinomatous craniopharyngioma cells
Authors: Liu Hao , Zhang Daobao , Liu Zhiyong , Liang Ruichao , Meng Tian , xu jianguo 
Published: December 2019

Abstract
Backgrounds Craniopharyngiomas are benign epithelial tumors and difficult to complete due to the digitate brain infiltration. miR-200c has been studied in terms of development, stemness, epithelial-mesenchymal transition (EMT), and therapy resistance in many cancers. However, the role of miR-200c remains to be elucidated in adamantinomatous craniopharyngioma.Methods Quantitative real-time polymerase chain reaction was used to evaluate the expression of miR-200c, ZEB1, ZEB2, and CTNNB1. Immunohistochemistry, Western blot, and immunofluorescence analyses were used to evaluate the expression of E-cadherin and β-catenin at the protein level. A Transwell assay was used to evaluate the invasiveness of ten primary craniopharyngioma cell.Results miR-200c was significantly downregulated in adamantinomatous craniopharyngioma compared with papillary craniopharyngioma. Conversely, ZEB1, ZEB2, and CTNNB1 were overexpressed in adamantinomatous craniopharyngioma. Inhibition of miR-200c significantly promoted the invasion of primary adamantinomatous craniopharyngioma cells. Moreover, E-cadherin was overexpressed and β-catenin was downregulated in miR-200c mimic primary adamantinomatous craniopharyngioma cell culture.Conclusion Our data demonstrated that miR-200c maybe reduce the invasive activity of adamantinomatous craniopharyngioma cells through E-cadherin/β-catenin. These findings suggest that the targets of miR-200c may regulate the EMT of adamantinomatous craniopharyngioma.
The Development of a Mobile Health App for Breast Cancer Self-Management Support in Taiwan: Design Thinking Approach
Authors: Hou I-Ching , Lan Min-Fang , Shen Shan-Hsiang , Tsai Pei Yu , Chang King Jen , Tai Hao-Chih , Tsai Ay-Jen , Chang Polun , Wang Tze-Fang , Sheu Shuh-Jen , Dykes Patricia C 
Published: December 2019

Background
Evidence has shown that breast cancer self-management support from mobile health (mHealth) apps can improve the quality of life of survivors. Although many breast cancer self-management support apps exist, few papers have documented the procedure for the development of a user-friendly app from the patient’s perspective.

Objective
This study aimed to investigate the information needs of Taiwanese women with breast cancer to inform the development of a self-management support mHealth app.

Methods
A 5-step design thinking approach, comprising empathy, define, ideate, prototype, and test steps, was used in the focus groups and individual interviews conducted to collect information on the requirements and expectations of Taiwanese women with breast cancer with respect to the app. A thematic analysis was used to identify information needs.

Results
A total of 8 major themes including treatment, physical activity, diet, emotional support, health records, social resources, experience sharing, and expert consultation were identified. Minor themes included the desire to use the app under professional supervision and a trustworthy app manager to ensure the credibility of information.

Conclusions
The strengths of the design thinking approach were user-centered design and cultural sensitivity. The results retrieved from each step contributed to the development of the app and reduction of the gap between end users and developers. An mHealth app that addresses these 8 main themes can facilitate disease self-management for Taiwanese women with breast cancer.
Breaking the Chains of Transactionalism: A Village Election without Money Politics in Panggungharjo
Authors: Bayo Longgina Novadona , Santoso Purwo 
Published: December 2019

The logic of corruption has seemingly been accepted as a normal part of democratic practices. This article challenges this logic, referring to the successful example of Panggungharjo, a village on the outskirts of Yogyakarta.[1]Without romanticising this village and its experiences, this article seeks to show the decisions and steps necessary for realising change and breaking the chains of transactionalism. Change is only possible if both the supply of and demand for money politics are cut off. Transformation is only possible when changes occur in supply and demand. In other words, transactionalism can only be avoided in electoral politics when a shift in demand coincides with the stigmatisation of transactional practices.[1] Administratively, Panggungharjo is part of Bantul Regency. However, it is sociologically a sub-urban part of Yogyakarta City.
Pemantauan Kateterisasi Jantung Pada Tindakan Percutaneous Transluminal Coronary Angioplasty Terhadap Pasien Coronary Artery Disease
Authors: Pratiwi Fuji 
Published: December 2019

Coronary Artery Disease (CAD) merupakan kondisi dimana terjadi penumpukan plak pada arteri koroner yang menyebabkan arteri koroner menyempit. Kondisi ini biasanya disebabkan oleh terkumpulnya kolestrol sehingga membentuk plak pada dinding arteri dalam jangka waktu yang cukup lama yang disebut aterosklerosis. CAD dapat menyebabkan otot jantung melemah, dan menimbulkan komplikasi seperti gagal jantung dan gangguan irama jantung. Percutaneous Transluminal Coronary Angioplasty (PTCA) atau dikenal juga dengan sebutan Percutaneous Coronary Intervention (PCI) adalah tindakan minimal invasif dengan melakukan pelebaran dari pembuluh darah koroner yang menyempit dengan balon dan dilanjutkan dengan pemasangan stent (gorong-gorong) agar pembuluh darah tersebut tetap terbuka. Tindakan dilakukan dengan hanya insisi kulit (Percutaneous) yang kecil, kemudian dimasukkan kateter ke dalam pembuluh darah (Transluminal) sampai ke pembuluh koroner dan dilakukan tindakan intervensi dengan inflasi balon dan pemasangan stent (Coronary Angioplasty) agar melebarkan pembuluh darah koroner kembali.
Penelitian ini merupakan studi deskriptif dari laporan kasus seorang pasien dengan usia 70 tahun, laki – laki dengan diagnosa pasien CAD. Pengambilan data angiografi dilakukan langsung dari ruang Kateterisasi Jantung Rumah Sakit.
Berdasarkan hasil tindakan Percutaneous Coronary Intervantion (PCI) telah mampu membuka aliran darah yang mengalami penyempitan untuk dapat menyalurkan darah ke otot jantung. Aliran pembuluh darah diperlihatkan dari hasil Angiografi. Hasil gambaran Angiorgrafi menunjukan perbedaan perubahan penyempitan pada pembuluh darah arteri koroner pasca PCI.
Kata Kunci : CAD, PTCA, PCI
Tindakan Percutaneous Coronary Interventio Pada Penilaian Grade Disfungsi Diastolik dan Tekanan Pengisian Ventrikel Kiri pada Pasien Gagal Jantung
Authors: Chumairoh Siti 
Published: December 2019

Gagal jantung merupakan kumpulan gejala kompleks yang dihasilkan dari gangguan struktural atau fungsional dari pengisian ventrikel kiri atau pemompaan ventrikel kiri. Disfungsi diastolik mempunyai pengaruh besar pada status keluhan, kapasitas fungsional, terapi, dan prognosis baik pada gagal jantung diastolik maupun gagal jantung sistolik terlepas dari etiologi dasar. Variabel kunci yang direkomendasikan untuk penilaian kelas disfungsi diastolik ventrikel kiri yaitu rasio E/A, rasio E/e’ dan Left Atrial Volume Indeks (LAVI). Penulisan menggunakan metode deskriptif. Dengan total jumlah 100 pasien gagal jantung sistolik dan diastolik.
Berdasarkan total pasien, didapatkan 83% pasien dengan Heart Failure with reduced Ejection Fraction
(HFrEF) EF < 50% dan 17% pasien dengan Heart Failure with perserved Ejection Fraction (HFpEF) EF
≥ 50%. Pada HFrEF 19.3% pasien dikategorikan grade I, 7.2% pasien grade II, 30.1% pasien dengan grade III, dan 42.2% pasien mengalami disfungsi diastolik. 80% pasien mengalami peningkatan pengisian ventrikel kiri dan 20% pasien dengan pengisian ventrikel kiri normal. Sedangkan pada HFpEF 17.5% pasien grade I, 23.5% pasien grade II, 6% pasien grade III, dan 53% pasien disfungsi diastolik. 47% pasien dengan pengisian ventrikel kiri normal dan 53% pasien dengan pengisian ventrikel kiri meningkat. Sebanyak 99% pasien mengalami disfungsi diastolik, dan 75% pasien mengalami peningkatan pengisian ventrikel kiri.
KataKunci: Gagal Jantung, Disfungsi Diastolik, Tekanan Pengisian Ventrikel Kiri, Ekokardiografi
Efektivitas Bantuan Hidup Dasar Untuk Teaga Kesehatan Indonesia
Authors: Nugroho Nyityasmono Tri 
Published: December 2019

Indonesia merupakan negara yang luas dengan populasi beragam pulau berpenghuni membutuhkan banyak pelatihan Bantuan Hidup Dasar (BHD) bagi tenaga kesehatan. Organisasi kemanusiaan non pemerintahan yaitu Bulan Sabit Merah Indonesia (BSMI) Jakarta Raya menyelenggarakan pelatihan tunggal di sejumlah Rumah Sakit Umum Daerah (RSUD) di seluruh Indonesia. Tujuan pelatihan yang dilakukan untuk meningkatkan ketersediaan tenaga ahli kesehatan dalam kemampuan BHD di Indonesia.
Studi ini merupakan penelitian operasional yang dilakukan untuk mengukur karakteristik dan efektivitas pelatihan BHD pada tenaga kesehatan. Data yang digunakan adalah seluruh peserta pelatihan dari RSUD. Pemilihan RSUD dilakukan sesuai dengan kriteria inklusi, sedangkan pemilihan peserta pelatihan dipilih oleh komite lokal di RSUD setempat dengan metode simple consecutive sampling. Data dianalisa menggunakan perangkat lunak statistik.
Karakteristik peserta didominasi perempuan, tenaga kesehatan perawat dan bidan, tingkat pendidikan terakhir diploma dan belum pernah mengikuti pelatihan BHD. Hasil evaluasi pelatihan menunjukan peningkatan signifikan antara nilai test sebelum dan sesudah pelatihan.
Kesimpulan pelatihan BHD tunggal dalam satu hari penuh mencakup ujian teori dan praktikum RJP dinilai efektif untuk tenaga kesehatan. Pelatihan BHD ini diselenggarakan dapat meningkatkan kualitas tenaga kerja di RSUD di Indonesia.
Kata kunci: BHD, Pelatihan, Rumah Sakit, Tenaga Kesehatan, Indonesia
Determinan Kematian Neonatal Pada Bayi Berat Lahir Rendah di Indonesia (Analisis Data SDKI 2002-2003 dan 2007)
Authors: Suraya Izza 
Published: December 2019

Determination of Neonatal Death in Low Birth Weight Infants in Indonesia (Data Analysis of IDHS 2002-2003 and 2007) Introduction. There were 72.4% infants with less than 2.500 grams Low Birth Weight (LBW) babies diedin their neonatal period in Indonesia. An understanding of all factors that influenced the neonatal deathis important. Therefore, this study was conducted to identify factors of LBW neonatal death between 1997and 2007. Methods. Based on 2002-2003 and 2007 Indonesia Demographic Health Survey, 1,232 LBW babies areselected. The design of study was cohort prospectif with cox proportional hazard analysis to measure therelationship between neonatal death and its determinants maternal, infant, health care, and mother’ssocial demographic. Resuls. After controlling all the variables, the result showed that neonatal death in LBW babiesdeteriminants are immediate breastfeeding, birth weight, sex, the term of birth, complications duringpregnancy, delivery complications, birth attendance, type of delivery, place of delivery, wealth index, andmother’s education. Variable that showed strongest risk association is complications during pregnancywith HR = 4.12 (95 % CI : 0.64- 26,65; p value = 0.307). Meanwhile, the strongest of protectiveassociation is middle class on wealth index variable. Conclusions. The study concluded that birth weight influences the incidence of neonatal death.Determinant that have the greatest effect on neonatal death is complications during pregnacy. Infantswho born from middle-class economic categories are the most protective factor to avoid neonatal deathsamong other wealth indexes.
THE INFLUENCE OF LEADERSHIP EMOTIONAL INTELLIGENCE AND COMMITMENT OF SCHOOL ORGANIZATION ON SELF EFFICACY
Authors: SETIADY Laksmitha Putri 
Published: December 2019

The aim of this research was to reveal the influence of Leadership Emotional Intelligence (x1) and Commitment of School Organization (x2) on Teacher Self Efficacy (x3). Hypotheses tested: (1) there is a direct and positive influence of Leadership Emotional Intelligence on Teacher Self Efficacy, (2) there is a direct and positive influence of Commitment of School Organization on Teacher Self Efficacy, (3) there is a direct and positive influence of Leadership Emotional Intelligence on Commitment of School Organization. Applying Slovin Formula, 109 teachers were proportionally and randomly surveyed out of population 151 teachers. The researcher used validated and reliable questionnaires for collecting data. Croanbach’s reliability tested Likert Scales. Statistical requirements for analyses were fulfilled using test of normality (Liliefors), test of linearity and test of homogeneity. In this study the researcher used simple regression and path analyses and found that Leadership
Emotional Intelligence and Commitment of School Organization have direct and positive influence on Teacher Self Efficacy.
INTEGRASI EMPAT PILAR PENDIDIKAN (UNESCO) MELALUI PENDIDIKAN HOLISTIK BERBASIS KARAKTER DI SMP MUHAMMADIYAH 1 PRAMBANAN
Authors: Juliani Wikanti iffah , Widodo Hendro 
Published: December 2019

Abstract
Education is an attempt to find information that is useful for life. Learning to know something (learning to know) becomes an effort that is done in getting useful knowledge and that is not useful. Knowledge and experience gained are then applied to solve problems that arise and get a change. This mastery of knowledge will lead students to find their true identity and develop their potential. After all these learning processes are passed, a student will be able to adapt to the environment and carry out his role in the community. Learning outcomes that students will get depend on the contribution of the curriculum that has been made. Therefore, in making a curriculum, it is pursued according to needs, not fragmented and can reflect all aspects thoroughly and contextually. The integrity requires a good character to make it clearer in bringing out a complete person.
LIDERANÇA E AUTONOMIA NAS NOVAS FORMAS DE ORGANIZAÇÃO DO TRABALHO: COMPARANDO EMPRESAS DO PORTO DIGITAL DE PERNAMBUCO
Authors: Da Conceição Neto Vera Lúcia , Moura Guilherme Lima 
Published: December 2019

Este artigo apresenta os resultados de uma pesquisa sobre construção da autonomia no ambiente de trabalho em Novas Formas de Organização do Trabalho (NFOT). Especificamente, analisou como a autonomia dos funcionários se estrutura na relação com os líderes em duas empresas de Tecnologia da Informação (TI), situadas no Porto Digital de Pernambuco. Nas NFOT, a liderança e a autonomia dos liderados são questões centrais das relações interpessoais no ambiente organizacional carregadas de conflitos, poder, contradições, motivações, mediações e busca pela eficiência. A abordagem teórica assume as NFOT como organizações burocráticas, que se distinguem por (supostamente) incorporarem com mais intensidade: flexibilidade; inovação; horizontalização da estrutura; foco em competências; trabalho em equipe; envolvimento e participação dos profissionais (CLEGG; HARRIS; HÖPFL, 2011; KOVÁCS, 2006). Compreende a liderança como uma proposta de linguagem, propriedade não exclusiva dos líderes formais, espaço de um processo de construção das relações através de negociações, renegociações, reconstruções, ressignificados (HOSKING, 1988; HOSKING; DACHLER, 1995; HOSKING, 2006). A pesquisa foi qualitativa, cujos dados foram obtidos através de vinte entrevistas semiestruturadas, aplicadas a líderes e liderados de duas empresas de TI, e submetidos à Análise Crítica do Discurso (FAIRCLOUGH, 2008). Foi constatado que organizações vistas como NFOT nem sempre são ambientes de estímulo à autonomia. Por outro lado, numa mesma organização, práticas flexíveis da liderança podem coexistir com práticas tradicionais de controle burocrático. O líder tem um papel fundamental, uma vez que sua personalidade pode imbricar na estrutura organizacional um estímulo ao engajamento do poder.
f-biharmonic and bi-f-harmonic submanifolds of generalized (k, µ)-space-forms
Authors: Hui Shyamal Kumar , Breaz Daniel , Mandal Pradip 
Published: December 2019

Abstract
Here we have studied f-biharmonic and bi-f-harmonic submanifolds of generalized (k, µ)-space-forms and obtained a necessary and sufficient condition on a submanifold of generalized (k, µ)-space-form to be f-biharmonic and bi-f-harmonic submanifold. We have also studied f-biharmonic hypersurfaces of said ambient space forms.
Study of MV-algebras via derivations
Authors: Wang Jun Tao , She Yan Hong , Qian Ting 
Published: December 2019

Abstract
The main goal of this paper is to give some representations of MV-algebras in terms of derivations. In this paper, we investigate some properties of implicative and difference derivations and give their characterizations in MV-algebras. Then, we show that every Boolean algebra (idempotent MV-algebra) is isomorphic to the algebra of all implicative derivations and obtain that a direct product representation of MV-algebra by implicative derivations. Moreover, we prove that regular implicative and difference derivations on MV-algebras are in one to one correspondence and show that the relationship between the regular derivation pair (d, g) and the Galois connection, where d and g are regular difference and implicative derivation on L, respectively. Finally, we obtain that regular difference derivations coincide with direct product decompositions of MV-algebras.
Country-Specific Determinants of Textile Industry Development in Poland: Comparative Analysis of the Years 2007 and 2017
Authors: Jabłońska M. , Stawska J. , Czechowska D.I. 
Published: December 2019

AbstractThe textile industry is a significant sector of the Polish economy and is characterized by a strong potential. Its development can be ensured by activities in the areas of finance, technical infrastructure, environmental protection, and demographic conditions. The development of the textile sector is significantly affected by factors such as quality of commune and poviat roads, length of the sewerage network, expenditure on environmental protection, expenditures on innovative activity and on research and development, and costs related to employment and population of working age. The aim of this paper is to determine the attractiveness level of individual Polish regions for the development of the textile sector in relation to five microclimates, which somehow define the most important determinants of the development of this sector of the economy. In order to achieve this aim, the following research methods are used: presentation of statistical data and statistical methods of research. The authors test the research hypothesis that the growth potential of textile industry enterprises is the largest in the most prosperous provinces.
Economic and functional changes in the largest villages in Poland at the end of the 20th and the beginning of the 21st century
Authors: Sokołowski Dariusz 
Published: December 2019

AbstractThe article deals with selected aspects of the economic structure and functions of the largest villages in Poland. The main aim of the study is to investigate the diversity and changes that can be observed to have happened since before the fall of Communism in Poland. Large villages with populations exceeding 5,000 inhabitants are located in the same part of the rural–urban continuum as small towns, including many poviat (1) seats. For this reason, they are an interesting comparative category of settlement units. The study was based on a source database from the end of the last century and on contemporary public data from the REGON database. The comparison is based not only on various data, but also uses various research methodologies.
Territorial polarisation of the economy and population distribution in post-Soviet Russia
Authors: Fedorov Gennady 
Published: December 2019

Abstract
Scientists, experts, and politicians have differing views on polarisation and levelling in the development of regions. Many researchers consider polarisation to be an objective process that benefits the country and the region because labour productivity is higher in larger centres. As for social differences, many states (and the European Union as an organisation) redistribute part of their revenue from more prosperous regions to poorer ones using regional budget policies. The article provides useful data on the regional specificity of polarisation and levelling in Russia at macro-, meso-, and microregional levels based on statistical, economic and cartographic analysis. The article shows that in Russia the polarisation of the economy and population distribution strongly prevails over the levelling of regional differences.
Inclusiveness of Urban Land Administration in the City of Lusaka, Zambia
Authors: Lupale Mubanga , Hampwaye Godfrey 
Published: December 2019

AbstractMany cities in developing countries are experiencing urbanization characterised by the continu-ous proliferation of informal settlements. In the City of Lusaka over 70 percent of residents live in informal settlements. The purpose of this paper is to provide an account of how inclusive land administration is in the City of Lusaka using the perspective of good governance principles. The sample comprised 10 key informants purposively selected from government institutions/ civil society organisations and 60 respondents conveniently drawn from informal settlements. The findings were analysed thematically and using descriptive statistics. The findings show that there is need to create policies and legislation that assists in developing viable, liveable and inclusive townships. Most indicators of the five good governance principles recorded negative responses of at least 60 per cent. Formal urban land development arrangements in the city have not been able to cope with the demands of the majority of urban residents. The study suggests that land and housing policies be revised to serve a broader purpose beyond the provision of shelter in order to suit the dynamic and contemporary needs of specific societies. Further re-search is needed on tenure responsive land use planning in order to understand existing commu-nity dynamics (economic and social support networks) and implement practical changes for tackling informality if Zambian cities and communities are to be sustainable and resilient.