bluuebunny/crossref_metadata_2025_split huggingface dataset:
THYMIDINE KINASE AS A CAUSATIVE FACTOR FOR TYPE 1 HERPES SIMPLEX VIRUS RESISTANCE AGAINST ACYCLOVIR
Authors: Martina Lefaan Yannie Febby , Setiadhi Riani 
Published: August 2020

ABSTRACTBackground: Herpes Simplex Virus (HSV) infection demonstrates a high prevalence in the world. Acyclovir, one of guanine synthetic analogues, is commonly used to treat infections caused by HSV. HSV resistance against acyclovir may occur, especially in immunocompromised and immunocompetent patients, as the consequence of viral mutations. Thymidine kinase (TK) is an HSV tegument protein which plays an important role in HSV-1 resistance against acyclovir. Purpose: The purpose of this article is to review the mechanisms of TK mutation that cause HSV-1 resistance against acyclovir. Review: Acyclovir involves three stages of viral thymidine kinase phosphorylation to form acyclovir triphosphate. It prevents HSV replication by acting as a competitive inhibitor of viral DNA polymerase and a chain terminator in viral DNA synthesis. Resistance is associated with viral TK mutation that is encoded by UL23 gene. Long-term use of acyclovir may promote thymidine kinase mutation in immunocompromised and immunocompetent patients via three mechanisms, namely absolute insufficiency in TK activity (TK-negative), depletion in TK synthesis, and inability in TK phosphorylation which consequently hinders the phosphorylation of acyclovir. Herpes TK gene contains a series of cytosine and guanosine, that are important for the function and the mutation of HSV by producing incomplete or fewer enzymes as the result of nucleotide addition or elimination in homopolymer process. Conclusion: HSV-1 resistance against acyclovir is evolved from TK mutations, in the form of TK-negative, TK low-producing, and TK altered mutants, that are unable to phosphorylate TK and accordingly disrupt acyclovir phosphorylation to convert acyclovir triphosphate. Keyword : Acyclovir, Herpes simplex virus, Resistance, Thymidine kinase
Molecular docking tangeretin and kaempferol compound against antiapoptotic Bcl-xL: in silico study
Authors: Nitami Siska Febdian , Febriansah Rifki 
Published: August 2020

The plants that can be developed as a chemopreventive agent are orange peel (Citrus reticulata) and tea leaves (Camellia sinensis). This study aims to determine the chemopreventive agent of tangeretin and kaempferol in silico. In silico test was performed molecular docking by using Vina Autodock Software by deprecating tangeretin and kaempferol compounds against target protein Bcl-xL. Tangeretin and kaempferol have an affinity to the protein with score -5,8 kkal/mol and -6,4 kkal/mol, respectively. Tangeretin has a high potency in inhibiting activity against Bcl-xL protein, while kaempferol has less potency in inhibition of Bcl-xL protein.
Factors Affecting Income of Female Workers Producing Ketupat Casing and Their Contribution to Household Income
Authors: Marwati Siska , Rahajuni Dijan , Supadi Supadi 
Published: August 2020

This study aims to examine the effect of education level, working time, age, work experience and number of family members on income of female workers in Datar Village and measure the extent of income contribution of female workers producing ketupat casing to household income. The respondents were selected using the census method and data were analyzed using multiple linear. This study found that education level, working time, work experience and number of family members had a significant effect on income of female workers. Age had no effect on income of female workers. The variable with the strongest relationship to income of female workers was working time. The implications of this study are that in order to increase their income, the female workers should utilize the residue of ketupat casing production in the form of coconut sticks to make other handicrafts, such as woven plates and broom sticks. The crafts can be sold in order to increase income of female workers producing ketupat
AN ANALYSIS OF BPJS PATIENTS' SATISFACTION INDICATORS IN INPATIENT ROOM IN THE WALED REGIONAL GENERAL HOSPITAL
Authors: Yulyanti Depi , Devi Sintya , Wahyudin Wahyudin 
Published: August 2020

Background : Patient satisfaction is a major problem that occurs in hospitals. Waled allegedly complained about the hospital concerning concern in providing services to BPJS patients, and there were differences in BPJS patient visits in inpatient services in 2014 to 2015 as many as 720 patients, then sought an increase Back in 2016 as many as 255 patients. However, this increase was not significant at the time of the decline in 2015.
Aims: This study analyzes the indicators of BPJS patient satisfaction in the inpatient services of the Waled Hospital in 2018.
Methods: This type of research was quantitative with descriptive research methods. The research population was 178, obtained as many as 123 samples, sampling using purposive sampling technique. Data analysis used univariate analysis.
Results: The results of the study were 84.85% of patients satisfied with the service, as many as 78.8% of patients were satisfied with the doctor's service, as much as 78.2% of patients were satisfied with the care of nurses, as many as 94.3% of patients were satisfied with the patient's meal service, as many as 86 0% of patients were satisfied with medical facilities, as many as 85.9% of patients were satisfied with medication services, as many as 60.6% of patients were satisfied with the condition of hospital facilities, as many as 47.0% of patients were satisfied with the condition of the treatment room facilities, as many as 97 0% of patients are satisfied with outgoing administration services.
Conclusion: Hospitals can find out indicators of patient satisfaction that are still low, it is recommended that the hospital should make SPO complaints about damaged facilities so that the hospital knows and immediately fixes it. So that patient satisfaction can continue to increase.
EDUCATION LEVEL IN THE RELATION TO ADOLESCENTS PREGNANCY IN INDRAMAYU 2019
Authors: Rudiansyah Rudiansyah , Dartiwen Dartiwen 
Published: August 2020

Adolescents’ pregnancy negatively impacts their health and their babies, also gives socio-economics impacts and risks of premature birth, low birth weight (LBW) and bleeding that can increase maternal and infant mortality. This study aims to determine the relationship of education level with the pregnancy at the age of adolescence. This research using observational analytic design with cross-sectional to recognize the relationship between education level ties and pregnancy at the age of adolescence. The subject of this research is pregnant women in the North Coast Region of Indramayu who meet the inclusion criteria and are willing to sign the consent form after being given an explanation. The samples of 200 pregnant women were taken using consecutive sampling. The results obtained p-value = 0.045 smaller than the alpha value (<0. 05) it can be concluded that there is a relationship between the level of education of mothers with pregnancy in adolescence. Analysis we found the value of OR of 3.336 (95% CI 1.098 to 10.140) means, less educated mother 3.336 times risk higher to get married and pregnant at the age of adolescence. It is expected that health center, government worker and the Office of Religious Affairs (KUA) able to work together to provide better education for adolescents and prospective brides in order not to get pregnant at an early age.
PERILAKU HIGIENE PENGAMBILAN SAMPAH RUMAH TANGGA DI KALISARI PURWOKERTO UTARA KABUPATEN BANYUMAS
Authors: Heryanto Heryanto 
Published: August 2020

Latar Belakang: Upaya mencegah dan mengurangi angka kematian akibat penyakit, setiap individu dituntut memiliki kebiasaan dalam kehidupan sehari-hari, yaitu melaksanakan kebersihan pribadi sesuai dengan standar kebersihan dan kesehatan. Pekerjaan mengambil sampah rumah tangga di daerah Kalisari memiliki potensi risiko terkena berbagai jenis penyakit akibat kerja yang setiap hari berinteraksi dengan sampah, sehingga perilaku kebersihan individu diperlukan untuk mencegah risiko kegiatan kerja.
Metode Penelitian: Penelitian ini menggunakan pendekatan deskriptif kualitatif menggunakan teknik penentuan sampel purposive dan bola salju. Untuk mendapatkan data, peneliti menggunakan wawancara mendalam dan teknik observasi, sedangkan untuk mendapatkan informasi data yang valid, penelitian ini menggunakan triangulasi data, sumber, dan metode. Dalam upaya untuk mengeksplorasi informasi tentang kebersihan individu, pekerja yang mengambil peneliti limbah rumah tangga menggunakan subjek penelitian. Subjek penelitian adalah 5 pekerja dengan satu rasi bintang atau data telah mencapai titik jenuh dan tidak berbeda lagi.
Hasil: Dari hasil penelitian tentang kebersihan pribadi pekerja pengumpul sampah, pekerja belum dapat secara definitif memahami pengetahuan kebersihan individu. Sikap pekerja mendukung mendukung kebersihan individu dan beberapa telah menggunakan APD, yaitu sepatu topi yang bagus. Sarana prsarana di tempat kerja, tidak semua pekerja menggunakan atribut kerja yang lengkap, yaitu APD. Petugas Puskermas dalam hal ini petugas sanitasi memberikan konseling dalam upaya memberikan informasi kebersihan pribadi.
Analisis Efektivitas Program Pos Peduli Gizi Anak Berbasis Potensi Lokal
Authors: Chomawati Rina , Handayani Oktia Woro Kasmini 
Published: August 2020

ABSTRAK
Tahun 2016, prevalensi gizi kurang di Mijen lebih tinggi daripada angka prevalensi di Kota Semarang yaitu sebesar 4,2%. Tujuan penelitian yang dilakukan pada bulan Mei 2018 ini adalah mengidentifikasi sejauh mana program Pos Peduli Gizi Anak Berbasis Potensi Lokal efektif dalam mengatasi masalah gizi di Mijen. Jenis penelitian adalah field research dengan teknik mixed method analysis. Fokus penelitian adalah efektivitas program meliputi input, process dan output. Sembilan informan ditentukan menggunakan teknik purposive sampling. Analisis data kualitatif menggunakan Miles dan Huberman sedangkan data kuantitatifnya menggunakan deskriptif persentase dengan kriteria keefektian Arikunto (2002). Hasil menunjukkan bahwa input program berjalan sesuai dengan SOP, process program yaitu penemuan kasus gizi efektif (60%), penanganan kasus gizi cukup efektif (50%) dan pendampingan kasus gizi efektif (60%). Output program, ada perbedaan berat badan pada balita sebelum dan sesudah intervensi yaitu kisaran 0,3 kg-1,9 kg. Status gizi tidak bisa didefinisikan karena durasi pelaksanaan program yang kurang. Simpulan penelitian yaitu program Pos Peduli Gizi Anak berbasis Potensi Lokal efektif untuk mengatasi masalah gizi di daerah urban fringe.
RELATIONSHIP SUPPORT OF WORK PLACES WITH EXCLUSIVE BREASTFEEDING ON WORKING MOTHERS
Authors: Santi Mina Yumei , Santoso Sabar , Sholihah Nasyiatush 
Published: August 2020

United Nation Childrens Fund dan World Health Organization merekomendasikan pemberian ASI eksklusif untuk menurunkan angka mortalitas dan morbiditas bayi. Ibu bekerja cenderung tidak memberikan ASI eksklusif dibandingkan ibu yang tidak bekerja atau ibu rumah tangga. Kurangnya dukungan tempat kerja menjadi salah satu faktor penyebab kegagalan ASI eksklusif pada ibu bekerja. Cakupan ASI eksklusif di wilayah Puskesmas Sewon II menurun dari tahun 2015 ke 2016 dan menjadi salah satu puskesmas dengan cakupan terendah di Kabupaten Bantul. Tujuan penelitian untuk mengetahui hubungan dukungan tempat kerja dengan pemberian ASI eksklusif pada ibu bekerja di wilayah kerja Puskesmas Sewon II. Metode yang digunakan observasional analitik dengan desain cross sectional. Sampel diambil dengan teknik purposive sampling dan melibatkan 70 responden yaitu ibu balita yang bekerja. Pengambilan data menggunakan kuesioner yang telah diuji validitas dan reliabilitas. Analisis data menggunakan uji statistik chi-square. Hasil studi menunjukkan terdapat hubungan antara dukungan tempat kerja dengan pemberian ASI eksklusif pada ibu bekerja dengan p-value 0,011 (α = <0,05) dan keeratan hubungan rendah dengan coefficient contingency 0,291. Karakteristik responden yang berhubungan dengan ASI eksklusif yaitu pendidikan, paritas, dan durasi kerja. Tempat kerja diharapkan memberikan waktu, sarana prasarana, dan kebijakan yang mendukung ASI eksklusif pada ibu bekerja sesuai dengan peraturan pemerintah.
EFEKTIVITAS PELATIHAN OPTIMALISASI PERAN TOKOH MASYARAKAT TERHADAP PENGETAHUAN TENTANG DIABETES MELITUS DAN PERANNYA DI DESA BABAKAN KECAMATAN KARANGLEWAS
Authors: Kurniawan Arif , Anandari Dian , Rubai Windri Lesmana , Machfiroh Arrum Firda Ayu 
Published: August 2020

Tokoh agama dan tokoh masyarakat yang berada di perdesaan mempunyai dukungan lebih rendah dalam mencegah Diabetes Melitus. Survey pendahuluan menunjukkan pengetahuan tokoh agama dan tokoh masyarakat di Desa Babakan masih rendah, dan belum optimalnya peran tokoh masyarakat sebagai penyuluh, peran tokoh masyarakat sebagai penggerak, peran tokoh masyarakat sebagai motivator, peran tokoh masyarakat sebagai katalisator, dan peran tokoh masyarakat sebagai teladan dalam mencegah diabetes mellitus di Desa Babakan. Penelitian ini bertujuan mengetahui efektifitas pelatihan dengan metode ceramah, diskusi dan praktek dalam peningkatan pengetahuan tentang diabetes melitus, dan pengetahuan tentang peran tokoh masyarakat dalam mencegah diabetes melitus. Penelitian ini menggunakan metode quasi experiment one group pre test-post test design pre dan post without control. Populasi dalam penelitian ini adalah tokoh masyarakat dan tokoh agama di desa Babakan. Sampel penelitian ini adalah total populasi sejumlah 32 orang. Hasil penelitian menunjukkan pelatihan tidak efektif meningkatkan pengetahuan tentang diabetes melitus, namun efektif meningkatkan pengetahuan tentang peran tokoh masyarakat dan tokoh agama dalam mencegah diabetes melitus di desa Babakan.
Authors: Rosmiati Rosmiati Ros , Jindar Sri Wahyuni 
Published: August 2020

Menarche (haid pertama) merupakan haid yang pertama kali terjadi pada dinding rahim dan yang dikenal dengan istilah darah haid, haid pertama tanda kesiapan biologis, dan tanda siklus masa subur telah mulai. Kesiapan menghadapi menarche adalah keadaan yang menujukkan bahwa seseorang siap untuk mencapai salah satu kematangan fisik yaitu datangnya menarche, hal ini ditandai dengan adanya pemahaman pengetahuan yang mendalam tentang proses menstruasi sehingga siap menerima dan mengalami menarche sebagai proses yang normal. Ketidaktahuan remaja tentang menstruasi dapat mengakibatkan anak sulit untuk menerima menarche. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan dengan kecemasan remaja putri menghadapi menarche. Dalam penelitian ini jenis penelitian yang digunakan adalah jenis penelitian non eksperimen dengan metode survey analitik dengan menggunakan pendekatan cross sectional. Pengambilan sampel menggunakan teknik purposive sampling, didapatkan 66 responden sesuai dengan kriteria inklusi. Pengumpulan data dilakukan dengan menggunakan kuesioner dan diuji dengan menggunakan uji statistik chi square dimana α =0,002 dengan bantuan statistical package for social science (SPSS) Hasil analisis bivariate didapatkan bahwa ρ yaitu 0,002 sedangkan nilai α =0,05. Maka dapat disimpulkan bahwa ada hubungan pengetahuan tentang menarche dengan kecemasan menghadapi menarche pada siswi kelas VII SMP Negeri 12 Makassar.
Anti-inflammatory Mechanism of Rhein in Treating Asthma Based on Network Pharmacology
Authors: Feng Junfang , Chen Ou , Wang Yibiao 
Published: August 2020

Abstract
Background: Network pharmacological methods were used to predict the anti-inflammatory targets and related pathways of rhein in the treatment of asthma, and to elucidate its mechanism of action. In addition, we validated the anti-inflammatory effects of rhein in HBE cells. Methods: The corresponding targets of rhein were obtained from the TCMSP 2.3, and molecular docking was also performed. A network of predicted rhein targets was established and analysed with Cytoscape 3.7.1. The anti-inflammatory targets in the TTD database were searched to build a PPI network, which was merged with the ingredient-target network to screen anti-inflammatory targets associated with rhein. A network of anti-inflammatory rhein targets during the in vivo treatment of asthma was constructed to screen the anti-inflammatory targets related to asthma. KEGG enrichment analysis was performed with the Enrichr database and Cytoscape 3.7.1. The expression levels of proteins in the MAPK/NF-κB signalling pathway were assessed by western blot analysis. Results: Altogether, 17 targets were obtained. Epidermal active growth factor receptor (EGFR), E-selecting (E-SELE), macrophage migration inhibitory factor (MIF), and mitogen-activated protein kinase 14 (MAPK14) might be important anti-inflammatory targets of rhein during asthma treatment. We selected the MAPK signalling pathway to determine the anti-inflammatory effects of rhein. Conclusion: The anti-inflammatory mechanism of the treatment of asthma with rhein may be related to MAPK14, EGFR, E-SELE and MIF as well as their signalling pathways. To prevent the exacerbation of asthma, instead of targeting a single pathway or a single target, all these targets and their signalling pathways should be controlled holistically. Rhein may reduce inflammation by inhibiting the MAPK/NF-κB pathway.
Efficacy of contrast-enhanced ultrasonography and shear-wave elastography in conjunction with BI-RADS classification for diagnosis of small breast nodules
Authors: Shen Yan , He Jie , Liu Miao , Hu Jiaojiao , Wan Yonglin , Zhang Tingting , Ding Jun , Dong Jiangnan , Fu Xiaohong 
Published: August 2020

Abstract
Background: Identification of malignancy in small breast nodules can be difficult using conventional methods, especially in patients with dense breast tissue. Advanced imaging techniques, including contrast-enhanced ultrasound (CEUS) and shear-wave elastography (SWE), could be used in conjunction with Breast Imaging Reporting and Data System (BI-RADS) classification to characterize these nodules more effectively. This study aimed to evaluate the use of CEUS and SWE for the differentiation of benign from malignant small (≤ 2 cm) breast nodules.Methods: This retrospective study reviewed the medical records and imaging data of 302 patients who underwent evaluation for 305 small breast nodules from November 2015 to December 2019. BI-RADS classification of nodules and the results of CEUS and SWE were retrospectively analyzed; the diagnostic efficacy of these techniques was evaluated by comparison with pathology results. Receiver operating characteristic curves were analyzed based on the CEUS patterns and shear-wave velocity values of nodules. The sensitivities, specificities, positive and negative predictive values, and accuracies of BI-RADS, CEUS, SWE, and a combination of all three methods for identifying benign versus malignant small breast nodules were investigated.Results: CEUS was effective at diagnosing malignant nodules when at least two out of nine suspicious features were present. Receiver operating curve analysis revealed that the best cut-off value for SWE was 3.7 m/s. For the diagnosis of benign breast nodules, the BI-RADS classification was reduced by one level when both CEUS and SWE were used, and was unchanged when either CEUS or SWE alone were used; the highest and lowest levels were category 5 and 3, respectively. Furthermore, when using the combined method, 75.8% (91/120) of small breast nodules with a BI-RADS category 4A classification avoided the need for coarse needle biopsies.Conclusion: Both CEUS and SWE can be used as auxiliary methods for clarifying BI-RADS classification of breast nodules, and a combination of these techniques may provide more diagnostic efficacy for identifying malignancy in small breast nodules.
Decreasing the leakage of continuous femoral nerve catheter fixation using 2 - octyl cyanoacrylate glue ( Demabond® ): A Randomized Controlled Trial study
Authors: Chalacheewa Theerawat , Arnuntasupakul Vanlapa , Sangkum Lisa , Buachai Rungrawan 
Published: August 2020

Abstract
Background : Continuous peripheral nerve catheters (CPNCs) have been used for postoperative pain relief. The common problem with CPNCs is pericatheter leakage that can compromise the sterile dressing, un-necessitating frequent dressing that may increase the risk of dislodgement and perineural catheter colonization or infections. Adhesive glue is useful for fixing peripheral nerve catheter as well as prevent leakage around the puncture site. This study aimed to evaluate the incidence of pericatheter leakage by using fixation with 2 -octyl cyanoacrylate glue (Demabond) compared to sterile strip. Methods : Thirty patients undergoing unilateral total knee arthroplasty and received continuous femoral nerve block were randomized to perineural catheter fixation with 2-octyl cyanoacrylate glue or sterile strip. The primary outcome was the incidence of pericatheter leakage. Secondary outcomes included frequent of catheter migration, difficulty of catheter removal, pain score and patient satisfaction. Results : The incidence of pericatheter leakage at 48 hours was 0% versus 100% in the intervention and control group. The incidence of displacement at 24 and 48 hours was 6.7% versus 93.3% and 6.7% versus 100%, respectively (P < 0.001). There was no difference in numeric rating scale, difficulty of catheter removal as well as satisfaction scores between groups. Conclusion : Catheter fixation with 2-octylcyanoacrylate reduced the incidence of pericatheter leakage as well as catheter displacement over 48 hours compare to sterile strip.
Long-term Condition Management for Prisoners: Improving the Interface Between Community and Prison
Authors: Wright Nat , Hankins F , Hearty P 
Published: August 2020

Abstract
Background: Prisoner populations have a disproportionately high prevalence of risk factors for long-term conditions (LTCs), and movement between community and prisons is a period of potential disruption in the ongoing monitoring and management of LTCs. Method: 19 qualitative interviews with staff, recruited by purposive sampling for professional background, were conducted to explore facilitators and barriers to screening, monitoring and medicines management for LTCs.Results: There is variability in prisoner behaviours regarding bringing community GP-prescribed medication to prison following arrest and detention in police custody, which affects service ability regarding seamless continuation of community prescribing actions. Systems for actively inputting clinical data into existing, nationally agreed, electronic record templates for QOF monitoring are under-developed in prisons and such activity is dependent upon individual “enthusiast(s)”. Similarly, compared to community systems, prison-based systems for “e-prescribing” functionality are under-developed. Conclusion: There is a pressing need to embed standardised QOF monitoring systems within an integrated community/prison commissioning framework, supported by connectivity between prison and community primary care records, including all activity related to QOF compliance. Developing systems for e-prescribing and wider medicines management can improve the quality of care for LTCs. Prison-based general practice has historically not been equivalent to that offered in community settings. Current pressing threats to community equivalence are that QOF monitoring systems are not embedded within prison healthcare payment structures and prison e-prescribing systems are underdeveloped. Supporting wider connectivity between prison and community GP records, including all activity related to QOF compliance and developing systems for e-prescribing had the potential to improve the quality of LTC care for this vulnerable group.