bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidências de validade semântica e de conteúdo na construção de um Instrumento de Avaliação da Percepção sobre a Morte e o Luto.
Authors: Carvalho Gueidia Fernandes , Gusmão Estefânea Élida da Silva , Viana-Meireles Livia Gomes 
Published: June 2020

Este estudo tem por objetivo relatar a construção, bem como a validação semântica e de conteúdo dos itens de um questionário de avaliação da percepção sobre morte e luto. O questionário objetiva compreender como as pessoas percebem a morte e o luto na atualidade. A formulação dos itens baseou-se na literatura clássica e recente sobre o tema. O questionário foi analisado por sete juízes, que sugeriram mudanças, inclusões e exclusões de algumas afirmações e foi respondido por 203 participantes. A análise semântica e de conteúdo mostrou que o questionário é de fácil compreensão, apontando para um instrumento com evidência de validade de conteúdo e semântica
Orthopaedic Guidelines for the COVID-19 Post-Outbreak Period
Authors: Xiong Yuan , Chen Lang , Lin Ze , Panayi Adriana C. , Mi Bobin , Liu Guohui 
Published: June 2020

Abstract:
Currently, the coronavirus disease 2019 (COVID-19) crisis has rapidly spread worldwide. As the earliest outbreak area of the pandemic, Wuhan, People’s Republic of China, is gradually recovering to its normal state under the effective control of government authorities. Outpatient services in major hospitals are now being restored. An accumulation of asymptomatic infections is a potential risk for medical personnel, especially when there is crowding in hospitals. As the biggest center for orthopaedic patients in Wuhan, our orthopaedic outpatient department admits >300 patients per day. Optimal guidelines on how to handle this huge number of patients during the post-outbreak stage of the COVID-19 pandemic, particularly with regard to potential asymptomatic infection, are urgently needed for orthopaedic surgeons. We have developed and proposed applicable guidelines to fill this knowledge gap, including the necessary protective strategies for medical personnel in orthopaedic outpatient and inpatient wards as well as during surgery. We also have provided mental health recommendations for health-care workers. To the best of our knowledge, these guidelines are the first of their kind for orthopaedic surgeons who are slowly reestablishing medical activity following the pandemic.
Comments: Recalibrating to a New Normal
Authors: Boschee Pam 
Published: June 2020

Pre-COVID-19 forecasts were blown out of the water and nearly made moot quickly in the first quarter of this year. Attempts to form long-term forecasts are stymied by uncertainties until some degree of stabilization returns to the oil and gas industry. The recent meteoric oil price dive plus the pandemic narrowed the window for defining “long term” with confidence.
For example, Fatih Birol’s comment, “We see early signs of a gradual rebalancing of oil markets. It is still gradual and it is still fragile,” might be interpreted as cautiously optimistic. The executive director of the International Energy Agency (IEA) also tweeted upon the release of the agency’s monthly report in mid-May … “the picture is still very bleak for the industry. After ‘Black April,’ the heaviest demand destruction may be behind us, but huge uncertain-ties remain. We now forecast global oil demand will fall by 8.6 mb/d in 2020.”
Global supply remains excessive but is being dialed back. In what previously would have been an unexpected twist, the US will be the single largest contributor to the historic drop in crude supply, a decline of 12 million B/D by the end of the year.
The shale operators, who not so long ago were producing at record levels, are now the primary drivers in decreasing global production largely by rapidly shutting in their wells, especially in the Permian and Bakken.
Non-OPEC producers will account for nearly one-third (approximately 4 million B/D) of the global supply drawdown. The US is forecast to rein in the majority (about 3 million B/D) - surpassing Saudi Arabia’s expected supply cuts, including its recent further reduction of 1 million B/D (bringing its expected daily production to 7.5 million instead of 8.5 million). Canada, Norway, and Brazil are also pulling back production.
Global supply may continue to outpace demand as lockdowns ease and consumption of oil and gas picks up in travel and individual and industrial activity, the duration and timing of which is unpredictable.
Although Brent and West Texas Intermediate crude prices remain down more than 50% year to date, they have rebounded from the recent fast and furious drops. The level of the rebound, however, does not yet come close to recovery across the industry. Over the short or long term, the definitions of recovery will be recalibrated to a changed “normal.”
Technology Focus: Coiled Tubing (June 2020)
Authors: Crabtree Alex 
Published: June 2020

As I think about this year’s Coiled Tubing feature, we are all in the midst of the effects of COVID-19 social distancing, an oil-price crash, and high levels of oil in storage. What will the world - and the oil industry, in particular - look like in a couple of months? Certainly, cash flow is going to be king among the various financial metrics. What can deliver results quickly and at a comparatively lower cash requirement? In many ways, these factors have played into the coiled tubing segment’s growth over the past couple of decades (i.e., delivering value). Will tomorrow be the same as just a few short months ago? In one sense - market size - no, but in another sense - as a segment that has always sought out and applied innovative, cost-effective solutions - yes.
The papers summarized in this year’s feature demonstrate the application and versatility of coiled-tubing-based solutions to different phases of a well’s life-cycle, from exploration through production and, finally, to abandonment.
In an exploration well, using coiled tubing to perform a drillstem test (DST) and potentially stimulate a zone of interest has long been a desire because it is perceived to be a cost-effect method over more-traditional methods. Paper SPE 199853 details the development and initial use of such a system that includes surface real-time readout, always desirable in a DST.
Moving into the later days of a well’s production phase, artificial lift typically is used to overcome the limitations of falling bottomhole pressure. In paper IPTC 19930, a detailed overview of a coiled tubing gas-lift installation is given, together with some of the production analysis used to determine the installation’s configuration. This technique has been used for several years around the globe, and some useful insights are shared by the authors.
Finally, coming to the end of a well’s life-cycle, is well abandonment. This is always a cost-sensitive lifecycle phase, even before today’s paradigm. The final paper of this year’s selection demonstrates how a coiled-tubing-based approach enabled a cost-effective plug and abandonment to be achieved while still meeting local regulatory requirements.
Remember, you may need to distance physically but you can stay connected by making use of, and participating in, your Society of Petroleum Engineers.
Stay well, everyone.
Technology Focus: EOR Operations (June 2020)
Authors: Goodyear Stephen 
Published: June 2020

As I write this, I am in Week 4 of working at home because of COVID-19. Like many sectors of the economy, the oil and gas industry is affected by the practical issues raised by social isolation but uniquely so by the dramatic fall in oil price triggered by a reduction in demand and the battle for market share between major producing countries. All this is set against the backdrop of the energy transition and the long-term effect this will bring for our industry’s energy products.
In difficult times, there is naturally a focus on maximizing the operational efficiency of existing assets, including enhanced-oil-recovery (EOR) operations and looking for capital-efficient ways to increase the resource base in existing assets.
In the longer term, the outlook for EOR, at first sight, might seem to be particularly challenged in the face of the energy transition. This is because of both the effect of an increased focus on the life cycle - or well-to-wheels - carbon intensity of each barrel produced and the expectation of the existence of stranded, unproducible hydrocarbon resources if we are to stay within a global carbon budget and prevent unmanageable temperature rises.
While some EOR technologies, particularly thermal, have unfavorable greenhouse-gas intensity metrics, others create the possibility of lower-intensity barrels. The increasing success in large-scale polymer flooding shows that EOR methods can recover more oil at reduced carbon intensity - more barrels with reduced water injection and produced-fluid handling. In the right circumstances, CO2 EOR can enable CO2 capture through the additional revenues it produces compared with pure storage or by producing barrels with a significantly lower carbon intensity that may qualify under low-carbon-fuel standards. Gas EOR, where it is managing associated gas to minimize flaring and venting of methane and CO2, also reduces the intensity of conventional waterflood and depletion barrels.
There is an apocryphal curse that says, “May you live in interesting times.” Like it or not, we live in interesting times, times of unprecedented change, challenge, and uncertainty; however, times such as these drive creativity. In the energy transition, there is the opportunity to innovate in EOR technology, deployment, and operations to deliver cost-effective and lower-intensity barrels.
Generation of human hair-bearing skin organoids from stem cells
Authors: Lee Jiyoon , Koehler Karl 
Published: June 2020

Abstract
Skin is a complex and vulnerable tissue that it is challenging to reconstitute once damaged. Here, we describe a three-dimensional organoid culture system that can generate fully stratified skin with its appendages from human pluripotent stem cells. This in vitro-based skin organoid culture system will benefit investigations into basic skin biology and disease modeling, as well as translational efforts to reconstruct or regenerate skin tissue.
Medical cannabis for the reduction of opioid dosage in the treatment of non-cancer chronic pain: A systematic review
Authors: Okusanya Babasola , Asaolu Ibitola O. , Ehiri John E. , Kimaru Linda Jepkoeach , Okechukwu Abidemi , Rosales Cecilia 
Published: June 2020

Abstract
Background: Medical cannabis (MC) is currently being used as an adjunct to opiates given its analgesic effects and potential to reduce opiate addiction. This review assessed if MC used in combination with opioids to treat non-cancer chronic pain would reduce opioid dosage.Methods: Four databases - Ovid (Medline), Psyc-INFO, PubMed, Web of Science, and grey literature – were searched to identify original research that assessed the effects of MC on non-cancer chronic pain in humans. Study eligibility included randomized controlled trials, controlled before-and-after studies, cohort studies, cross-sectional studies, and case reports. All databases were searched for articles published from inception to October 31, 2019. Cochrane’s ROBINS-I tool and the AXIS tool were used for risk of bias assessment. PRISMA guidelines was followed in reporting the systematic review.Results: Nine studies involving 7,222 participants were included. There was a 64%-75% reduction in opioid dosage when used in combination with MC. Use of MC for opioid substitution was reported by 32%-59.3% of patients with non-cancer chronic pain. One study reported a slight decrease in mean hospital admissions in the past calendar year (P=.53) and decreased mean emergency department visits in the past calendar year (P=.39) for patients who received MC as an adjunct to opioids in the treatment of non-cancer chronic pain compared to those who did not receive MC. All included studies had high risk of bias, which was mainly due to their methods. Conclusions: While this review indicated the likelihood of reducing opioid dosage when used in combination with MC, we cannot make a causal inference. Although medical cannabis’s recognized analgesic properties make it a viable option to achieve opioid dosage reduction, the evidence from this review cannot be relied upon to promote MC as an adjunct to opioids in treating non-cancer chronic pain. More so, the optimal MC dosage to achieve opioid dosage reduction remains unknown. Therefore, more research is needed to elucidate whether MC used in combination with opioids in the treatment of non-cancer chronic pain is associated with health consequences that are yet unknown.Systematic review registration: This systematic review was not registered.
Laparoscopic-assisted Soave operation for the treatment of Hirschsprung disease in children: 5 years of experience
Authors: Liu Mingkun , Fang Yifan , Zhang Bing , Lin Yu , Li Oumin , Bai Jianxi , Wu Dianming 
Published: June 2020

Abstract
Purpose The purpose of this study was to summarize the clinical experience of the laparoscopic-assisted Soave operation for the treatment of Hirschsprung disease in children. Methods In total, 186 children with Hirschsprung disease participated in this study from January 2014 to January 2019. The Soave operation was used to treat Hirschsprung disease with laparoscopic assistance. Symptoms and signs were followed up at one week, one month, three months, six months, one year and every 1-2 years after the first year. Results All 186 children underwent laparoscopic surgery successfully, and none progressed to open surgery. During hospitalization and follow-up, there were 49 patients with complications, including 1 patient with an anastomotic leakage, 1 with an anal stricture, 5 with constipation recurrence, 5 with dirty defecation, 22 with enterocolitis, and 15 with perianal erosion. There were no complications such as abdominal bleeding, abdominal infection, ureter injury, adhesive intestinal obstruction, anastomotic stricture, incontinence. Conclusion The laparoscopic-assisted Soave operation is a safe and feasible method for the treatment of Hirschsprung disease in children. This method has the advantages of less trauma and good cosmetic effects.
Reproductive capacity and recurrence of disease after surgery for moderate and severe endometriosis – a retrospective single center analysis
Authors: Schippert Cordula , Witte Yvonne , Bartels Janina , Garcia-Rocha Guillermo-José , Jentschke Matthias , Hillemanns Peter , Kundu Sudip 
Published: June 2020

Abstract
Background: Endometriosis can be associated with considerable pain and sterility. After surgical excision of moderate or severe endometriosis lesions, the rate of recurrence reaches up to 67%. The objective of this retrospective study was to establish the recurrence and pregnancy rates following surgical resection of stage III/IV endometriosis lesions. Indications for operation were endometriosis symptoms, sonographic findings and/or infertility. Methods : A total of 456 patients who underwent stage III/IV endometriosis surgery between 2004 and 2014 were sent a questionnaire relating to their postoperative medical treatment, pregnancies, relief of symptoms and recurrence. Responses of 206 patients (45.2%) and their clinical data were analysed for this study. Results : A total of 66.5% (N=137) of patients had stage III disease, and 33.5% (N=69) had stage IV disease. The average age was 37 years (17-59). A total of 63.1% (N=130) of surgeries were performed by laparoscopy, 21.8% (N=45) were performed by laparotomy and 15% (N=31) were performed by conversion. Complete resection of endometriosis lesions was achieved in 90.8% of patients (N=187). After surgery, 48.5% (N=100) of the women did not receive hormonal treatment; the main reason was the desire for children in 53%. Complete or partial relief in complaints was achieved in 93.2% (N=192). The rate of recurrence was 21.8% (N=45). The statistically significant factors that was associated with a higher risk to develop recurrence was an age <35 (p<0.005).After surgery, 65.8% (79/120) of patients who wished to have children became pregnant. There was a statistically significant association among a higher postoperative pregnancy rate and age <35 (p<0.003) in multivariante logistic regression analysis and laparoscopic surgical access in univariante logistic regression analysis (p<0.01). Conclusion: We assessed the high percentage of complete or partial relief of symptoms of 93.2%, the high postoperative pregnancy rate of 65.8% and the low rate of recurrence of 21.8% compared to international literature to be very encouraging for women suffering from moderate and severe endometriosis. Though laparoscopy is considered the ´gold standard` of endometriosis surgery, laparotomy still may be indicated in patients with extensive endometriosis especially to preserve reproductive function.
An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors
Authors: Trezza Alfonso , Iovinelli Daniele , Prischi Filippo , Santucci Annalisa , Spiga Ottavia 
Published: June 2020

Abstract
The Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2). The virus has rapidly spread in humans, causing the ongoing Coronavirus pandemic. Recent studies have shown that, similarly to SARS-CoV, SARS-CoV-2 utilises the Spike glycoprotein on the envelope to recognise and bind the human receptor ACE2. This event initiates the fusion of viral and host cell membranes and then the viral entry into the host cell. Despite several ongoing clinical studies, there are currently no approved vaccines or drugs that specifically target SARS-CoV-2. Until an effective vaccine is available, repurposing FDA approved drugs could significantly shorten the time and reduce the cost compared to de novo drug discovery. In this study we attempted to overcome the limitation of in silico virtual screening by applying a robust in silico drug repurposing strategy. We combined and integrated docking simulations, with molecular dynamics (MD), Supervised MD (SuMD) and Steered MD (SMD) simulations to identify a Spike protein – ACE2 interaction inhibitor. Our data showed that Simeprevir and Lumacaftor bind the receptor-binding domain of the Spike protein with high affinity and prevent ACE2 interaction.Authors Alfonso Trezza and Daniele Iovinelli contributed equally to this work.
The Infantile Neuroaxonal Dystrophy Rating Scale (INAD-RS)
Authors: Atwal Paldeep , Midei Mark , Adams Darius , Fay Alexander , Heerinckx Frederic , Milner Peter 
Published: June 2020

Abstract
Background: INAD is an autosomal recessive neurogenetic disorder caused by biallelic pathogenic variants in PLA2G6. The downstream enzyme, iPLA2, plays a critical role in cell membrane homeostasis by helping to regulate levels of phospholipids. The clinical presentation occurs between 6 months and 3 years with global developmental regression, hypotonia, and progressive spastic tetraparesis. Progression is often rapid, resulting in severe spasticity, visual impairment, and cognitive decline, with many children not surviving past the first decade of life. To date, no accepted tool for assessing the severity of INAD exists; other commonly used scales (e.g. CHOP-INTEND, Modified Ashworth, Hammersmith Functional Motor Scale) do not accurately gauge the current severity of INAD, nor are they sensitive/specific enough to monitor disease progression. Finally, these other scales are not appropriate, because they do not address the combination of CNS, peripheral nerve, and visual pathology that occurs in children with INADMethods: We have developed and validated a structured neurological examination for INAD (scored out of 80). The examination includes six main categories of pediatric developmental evaluation: 1) gross motor-and-truncal-stability skills, 2) fine motor skills, 3) bulbar function, 4) ocular function, 5) temporo-frontal function, and, 6) Functional evaluation of the autonomic nervous system. A cohort of patients diagnosed with INAD were followed prospectively to validate the score against disease severity and disease progression. Results: We show significant correlation between the total neurological assessment score and months since symptom onset with a statistically significant (p = 6.7 x 10-07) correlation between assessment score and disease onset. As hypothesized, the coefficient of months-since-symptom-onset is strongly negative, indicating a negative correlation between total score and months since symptom onset.Conclusion: We have developed and validated a novel neurological assessment score in INAD that demonstrates strong correlation with disease severity and disease progression.
Molecular detection of tick-borne pathogens in cattle from Saudi Arabia
Authors: Alanazi Abdullah D , Alouffi Abdulaziz S , Alshahrani Mohammad Y , Alyousif Mohamed S , Abdullah Hend H.A.M. , Allam Ahmad M , Elsawy Bassma S.M. , Abdel-Shafy Sobhy , Alsulami Muslimah N 
Published: June 2020

Abstract
Background: Babesiosis and anaplasmosis are tick-borne diseases that affect the health of cattle and may also be responsible for major economic losses. This study aimed to detect the presence of the causative agents of babesiosis and anaplasmosis among cattle in different provinces in Saudi Arabia and to characterise their species genetically. Methods: A total of 362 blood samples were taken from cattle in four regions (Riyadh, Al-Kharj, Al-Hasa and Al-Qassim) of Saudi Arabia and were molecularly screened by polymerase chain reaction (PCR) of partial 18S rRNA and 23S rRNA genes to detect Babesia and Anaplasma species. Results: The overall prevalence of Babesia and Anaplasma in cattle was 2.49% and 5.80%, respectively. Theileria annulata (T. annulata) and Theileria ovis (T. ovis) were found in seven (1.93%) and two (0.55%) of the 362 samples, respectively. Anaplasma ovis (A. ovis) was detected in 21 (5.80%) of 362 samples. Likewise, four of the cattle were found to be coinfected with more than one pathogen (1.10%). All cattle samples tested negative for other species of Babesia, Theileria and Anaplasma. Conclusions: The presence of T. ovis and A. ovis has been reported in Saudi Arabia. Here, the presence of two novel genotypes of T. annulata is also reported in Saudi Arabian cattle. Further molecular surveys on larger numbers of samples from the entire country are needed to correctly address the prevalence and geographical distribution of tick-borne disease.
Mild cognitive impairment in older adults: the role of cognitive reserve and resilience
Authors: Lam Bess Yin-Hung , Lai Daniel W.L. , Li Jessica , Zou Zhi , Chan Chetwyn C. H. 
Published: June 2020

Abstract
Background

Positive ageing amid of age-related neurodegeneration is a global challenge. The present study examined whether psychological resilience can be a protective factor among older adults.
Methods

The participants were 233 community-dwelling older individuals with or without mild cognitive impairment (MCI). They completed testing on resilience and the cognitive reserve proxies. Hierarchical logistic regression was conducted to test the hypotheses of the present study.
Results

After controlling for age and the cognitive reserve proxies, resilience (b= -0.38) and resilience × visuospatial function significantly predicted MCI group membership (ps < 0.05). There are two new findings. First, higher level of resilience in addition to the conventional cognitive reserve proxies predicted lower MCI risks. Second, MCI participants with higher level of resilience had significantly higher visuospatial ability than their lower level counterparts.
Conclusions

These findings raise the question of whether resilience should be considered as a cognitive reserve proxy. It also calls for future research to enhance the level of resilience in older adults for healthy ageing.