bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROBIOTIC STRAINS OF LACTOBACILLI AS IMMUNOMODULATORS: FOCUS ON LACTOBACILLUS RHAMNOSUS GG
Authors: KALYUZHIN O. V. 
Published: January 2020

Probiotics have long been considered not only as a way of correcting intestinal dysbiosis but also as a promising immunomodulatory solution. Over the past years, the evidence base for their effectiveness in the prevention and treatment of immuneassociated human diseases has substantially increased, the previously described mechanisms were specified and new components of the immunocorrective effect of probiotic bacteria, including those belonging to the genus Lactobacillus, have been deciphered. The meta-analytical findings and systematic reviews leave no doubt about the advisability of using certain probiotics, primarily Lactobacillus rhamnosus GG (LGG), in children for the treatment and prevention of various forms of acute diarrhea, including those associated with the administration of antibacterial agents, as well as for the prevention of respiratory infections. The results of testing the strain to be used as an adjuvant vaccine and a way of preventing atopic dermatitis are encouraging. The review analyzes the specific characteristics of present-day children who are more susceptible to allergic and infectious diseases, effector molecules of lactobacilli and signaling pathways that ensure their immunomodulatory effect, the main areas of therapeutic and preventive application and safety of probiotics, with a focus on LGG as one of the most studied and tested strains. In addition, the clinical efficacy of the synbiotic Normobakt L, a combination of LGG (4 × 109) plus fructooligosaccharides (800 mg),which has been approved in Russia for use in children with rotavirus infection against a background of atopic dermatitis, is demonstrated
RESULTS OF THE 15-YEAR STUDY OF METAPNEUMOVIRAL INFECTION. A LITERATURE REVIEW
Authors: KANNER E. V. , KRUTIKHINA S. B. , GORELOV A. V. 
Published: January 2020

The literature review presents information about a new respiratory pathogen that was discovered in the beginning of the XXI century, the metapneumovirus, epidemiological and clinical features of diseases caused by them and data on the pathogenesis and diagnosis of this disease are provided. Attention is drawn to the frequent combined course of metapneumoviruses infection with other respiratory infections
CLINICAL AND DIAGNOSTIC ASPECTS OF PREDICTION OF BRONCHIAL ASTHMA IN EARLY CHILDHOOD
Authors: PAVLENKO V. A. , MELNIKOVA I. M. , MIZERNITSKY Y. L. 
Published: January 2020

Diagnosis of bronchial asthma (BA) for babies in the first years of life is of particular interest in the practice of paediatric pulmonologist, as there is currently no reliable diagnostics, including functional criteria, to verify the disease at this age. The purpose of the study was to find additional clinical and functional criteria to forecast the formation of BA in early childhood.The study found that children who had undergone acute obstructive bronchitis (AOB) against the background of the perinatal CNS involvement (PCNSI), and consequently having pathoreceptor disorders and variability of the heart rate, had a longer and heavier period of AOB. It has been shown that the presence of PCNSI is an unfavourable factor in the prediction of repeatepisodes of AOB and development of BA. As a result of the follow-up study and the ROC analysis, additional criteria for the projection of BA in early childhood were identified, taking into account the functional state of the respiratory and vegetative nervous system. The additional criteria developed for the projection of BA in young children, together with the clinical and disease history data can contribute to early diagnosis of the BA, which has an important clinical significance for the timely delivery of curative and preventive measures
Kaempferol Improves TRAIL-Mediated Apoptosis in Leukemia MOLT-4 Cells by the Inhibition of Anti-apoptotic Proteins and Promotion of Death Receptors Expression
Authors: Hassanzadeh Ali , Naimi Adel , Hagh Majid F. , Saraei Raedeh , Marofi Faroogh , Solali Saeed 
Published: January 2020

Introduction:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) is a member of the tumor necrosis factor (TNF) superfamily, which stimulates apoptosis in a wide range of cancer cells via binding to death receptors 4 and 5 (DR4/5). Nevertheless, TRAIL has noticeable anti-cancer abilities; some cancer cells acquire resistance to TRAIL, and consequently its potential for inducing apoptosis in target cells is strongly diminished. Acute lymphoblastic leukemia MOLT-4 cell line is one of the most resistant cells to TRAIL that developed resistance to TRAIL via different pathways. We used TRAIL plus kaempferol to eliminate resistance of the MOLT-4 cells to TRAIL.Material and Methods:First, IC50 for kaempferol (95 µM) was determined by using the MTT assay. Second, the viability of the MOLT-4 cells was assayed by FACS after Annexin V/PI staining, following treatment with TRAIL (50 and 100 nM) and kaempferol (95 µM) alone and together. Finally, the expression levels of the candidate genes involved in resistance to TRAIL were assayed by real-time PCR technique.Results:Kaempferol plus TRAIL induced apoptosis robustly in MOLT-4 cells at 12, 24 and 48 hours after treatment. Additionally, we found that kaempferol could inhibit expression of the c-FLIP, X-IAP, cIAP1/2, FGF-8 and VEGF-beta, and conversely augment expression of the DR4/5 in MOLT-4 cells.Conclusion:We suggest that co-treatment of MOLT-4 cells with TRAIL plus kaempferol is a practical and attractive approach to eliminate cancers’ resistance to TRAIL via inhibition of the intracellular anti-apoptotic proteins, upregulation of DR4/5 and also by suppression of the VEGF-beta (VEGFB) and FGF-8 expressions.
Application of Optimization Technique to Develop Nano-Based Carrier of Nigella Sativa Essential Oil: Characterization and Assessment
Authors: Dawaba Aya M. , Dawaba Hamdy M. 
Published: January 2020

Background:
Chitosan, a naturally occurring polymer, has interesting applications in the
field of drug delivery due to its plentiful advantages as biodegradability, biocompatibility and nontoxic
nature. Nigella sativa essential oil is unstable, volatile, and insoluble in water and these problems confine
its usage in developing new medicines.

Objective:
This study focuses on developing a chitosan-based nanocarrier for the encapsulation of
Nigella Sativa essential oil. By using Quality by design outline, the quality target product outline, critical
quality attributes and critical material attributes were defined by knowledge and risk-based procedures.

Method:
According to defined critical material attributes, Optimization software (Statgraphics XVII)
was used to study the effect of the processing parameters. The processing parameters identified and
fixed first with a “One factor at a time” approach. Various physicochemical characterization techniques
were performed.

Results:
As a result, the ratio of chitosan to benzoic acid (2:1) along with the stirring rate (4000 rpm)
produced minimum-sized particles (341 nm) with good stability. The anti-bacterial activity study using
Staph. Aureus strain proved that the optimized nanoparticles were more efficacious than the pure oil
based on the diameter of inhibition zone obtained (diameter =5.5 cm for optimized formula vs diameter
= 3.6 cm for pure oil). Furthermore, MTT (methyl thiazolyl-diphenyl-tetrazolium bromide) assay was
performed to compare the in vitro cytotoxicity using two different cell lines (i.e. HCT 116 for colorectal
carcinoma and PC3 for prostatic cancer). It was found that in both cell lines, the optimized nanoparticles
had noteworthy antiproliferative properties illustrated by determining the concentration at which
50% of growth is inhibited (IC50). The optimized nanoparticles showed lower IC50 (17.95 ±0.82 and
4.02 ±0.12μg/ml) than the bare oil IC50 (43.56 ±1.95 and 29.72 ±1.41μg/ml).
Assessment of Contractors’ Claims on Construction Projects in Vietnam
Authors: Hai Dinh Tuan 
Published: January 2020

Background:Claims have increasingly become inevitable in construction projects. A great amount of money, time, and merit of claims are the most critical factors that prudent companies should not overlook.Objective:The objective of the study is to survey claim practices in the Vietnamese construction industry by collecting data from both contractors and consultants.Material and Methods:This paper presents findings that the lack of awareness of the on-site people is the major problem of claims management. Moreover, the inadequacy of supporting evidence, originating from the unawareness of personnel as well as improper documentation system, is also a serious problem causing the loss of chances to recover incurred damages.Conclusion:To overcome these problems, it is recommended that the management should pay more attention to these aspects in order to have effective claim management, by which unnecessary losses could substantially be reduced and deserving compensation would be recovered.
Efficacy of In-office Bleaching on Microhardness of Permanent Teeth with Antioxidant Re-hardening
Authors: Çakir Esra G , Özcan Suat , Tulunoglu Ibrahim , Üçtaşli Mine B. , Tulunoglu Ozlem 
Published: January 2020

Background:
Bleaching procedures affect surface enamel structure and decrease its bonding ability to resin composite restorative materials. The application of re-hardening materials to bleached enamel surfaces may prevent this decrease in micro-hardness.

Objective:
This in-vitro study aims to evaluate the surface micro hardness of human teeth enamel subjected to bleaching with Zoom Advanced Power 2 AP (Phillips, USA), and Opalescence Boost (Ultradent, USA) and compare the re-hardening effects of 10% Sodium Ascorbate, 2% acidulated phosphate fluoride gel, and a 5% Potassium nitrate 0.22% Sodium Fluoride + Calcium Nitrate gel.

Methods:
Ninety human third molar teeth were used. The specimens were randomly assigned to 5 groups. After the bleaching procedure, the specimens were treated with APF, Sodium Ascorbate or Relief gel as re-hardening agents with 30 teeth in each group. Enamel micro-hardness was measured with Vickers Micro-hardness Tester. The data were evaluated with Kolmogorov-Simirnov, one-way ANOVA, Dunnett’s test, post-hoc Tukey and T-tests.

Results:
Statistical analysis revealed no significant differences among initial enamel groups’ micro-hardness values (P>.05); however, significant differences occurred between initial and after bleaching treatment group value for G3 (P< .05). After re-hardening, only the Sodium Ascorbate group showed a statistically significant increase with hardness values (P< .05) for G4 and G5.

Conclusion:
Bleaching treatment conducted with light had no adverse effect on enamel micro-hardness. Sodium Ascorbate can be useful after bleaching to change the adverse effects of bonding on the enamel.
Comparing Methods for Record Linkage for Public Health Action: Matching Algorithm Validation Study
Authors: Avoundjian Tigran , Dombrowski Julia C , Golden Matthew R , Hughes James P , Guthrie Brandon L , Baseman Janet , Sadinle Mauricio 
Published: January 2020

Background
Many public health departments use record linkage between surveillance data and external data sources to inform public health interventions. However, little guidance is available to inform these activities, and many health departments rely on deterministic algorithms that may miss many true matches. In the context of public health action, these missed matches lead to missed opportunities to deliver interventions and may exacerbate existing health inequities.

Objective
This study aimed to compare the performance of record linkage algorithms commonly used in public health practice.

Methods
We compared five deterministic (exact, Stenger, Ocampo 1, Ocampo 2, and Bosh) and two probabilistic record linkage algorithms (fastLink and beta record linkage [BRL]) using simulations and a real-world scenario. We simulated pairs of datasets with varying numbers of errors per record and the number of matching records between the two datasets (ie, overlap). We matched the datasets using each algorithm and calculated their recall (ie, sensitivity, the proportion of true matches identified by the algorithm) and precision (ie, positive predictive value, the proportion of matches identified by the algorithm that were true matches). We estimated the average computation time by performing a match with each algorithm 20 times while varying the size of the datasets being matched. In a real-world scenario, HIV and sexually transmitted disease surveillance data from King County, Washington, were matched to identify people living with HIV who had a syphilis diagnosis in 2017. We calculated the recall and precision of each algorithm compared with a composite standard based on the agreement in matching decisions across all the algorithms and manual review.

Results
In simulations, BRL and fastLink maintained a high recall at nearly all data quality levels, while being comparable with deterministic algorithms in terms of precision. Deterministic algorithms typically failed to identify matches in scenarios with low data quality. All the deterministic algorithms had a shorter average computation time than the probabilistic algorithms. BRL had the slowest overall computation time (14 min when both datasets contained 2000 records). In the real-world scenario, BRL had the lowest trade-off between recall (309/309, 100.0%) and precision (309/312, 99.0%).

Conclusions
Probabilistic record linkage algorithms maximize the number of true matches identified, reducing gaps in the coverage of interventions and maximizing the reach of public health action.
Primary Care Doctor Characteristics That Determine the Use of Teleconsultations in the Catalan Public Health System: Retrospective Descriptive Cross-Sectional Study
Authors: Fernández Oscar Solans , Seguí Francesc López , Vidal-Alaball Josep , Bonet Simo Josep Maria , Vian Oscar Hernandez , Cabo Pascual Roig , Hernandez Marta Carrasco , Dominguez Carmen Olmos , Reig Xavier Alzaga , Rodríguez Yesika Díaz , Peralta Manuel Medina , Hermosilla Eduardo , León Nuria Martínez , Guimferrer Nuria , González Mercedes Abizanda , Cuyàs Francesc García , Sust Pol Pérez 
Published: January 2020

Background
eConsulta is a tele-consultation service involving doctors and patients, and is part of Catalonia's public health information technology system. The service has been in operation since the end of 2015 as an adjunct to face-to-face consultations. A key factor in understanding the barriers and facilitators to the acceptance of the tool is understanding the sociodemographic characteristics of general practitioners who determine its use.

Objective
This study aimed to analyze the sociodemographic factors that affect the likelihood of doctors using eConsulta.

Methods
A retrospective cross-sectional analysis of administrative data was used to perform a multivariate logistic regression analysis on the use of eConsulta in relation to sociodemographic variables.

Results
The model shows that the doctors who use eConsulta are 45-54 years of age, score higher than the 80th percentile on the quality of care index, have a high degree of accessibility, are involved in teaching, and work on a health team in a high socioeconomic urban setting.

Conclusions
The results suggest that certain sociodemographic characteristics associated with general practitioners determine whether they use eConsulta. These results must be taken into account if its deployment is to be encouraged in the context of a public health system.
Primary Sjögren’s Syndrome - A Review
Authors: Pittala Vyshnavi , Mallannagari Shivanjali , Sherla Harika , Kadarla Rohith Kumar 
Published: January 2020

Primary Sjögren’s syndrome is a systemic autoimmune disease. The hallmark of the disease is exocrinopathy, which often results in dryness of the mouth and eyes, fatigue, and joint pain. These three symptoms are present in more than 80% of the patients with this disease and have a major effect on quality of life, primarily because of disabling fatigue, with associated loss of work productivityThe global prevalence calculated for the rarer pSS is 61 per 100 000 inhabitants. The patients’ quality of life is reduced by the diverse manifestations of the disease. Pharmacists can help SjS(Sjögren’s Syndrome) patients improve their quality of life.
UV Spectrophotometric Method Development and Validation of Fimasartan Drug and Its Tablet Formulation
Authors: Agrawal Kaushik S , Gandhi Lokesh R , Bhajipale3 Nitin S. Bhajipale S 
Published: January 2020

A novel, safe and sensitive method of Spectrophotometric estimation in UV - region has been developed for the assay of Fimasartan in its tablet formulation. The present study was undertaken to develop and validate a simple, accurate, precise, reproducible and cost effective UV spectrophotometric method for the estimation of Fimasartan bulk and pharmaceutical formulation. The method have been developed and validated for the assay of Fimasartan using Methanol as diluent. Absorption maximum (λmax) of the drug was found to be 240nm. The quantitative determination of the drug was carried out at 240nm. The method was shown linear in the mentioned concentrations having correlation coefficient R2 of 0.999. The recovery values for Fimasartan ranged from 98.74% to 99.23%.The Percent Relative Standard Deviation of interday and intraday was 0.85% and 0.75% respectively. All the parameters of the analysis were chosen according to the International Conference on Harmonisation guideline and validated statistically using Relative Standard Deviation and Percent Relative Standard Deviation. Hence, proposed method was precise, accurate and cost effective. This method could be applicable for quantitative determination of the bulk drug as well as dosage formulation.

KEY WORDS:
Pengaruh Medium Dan Filter Arang Aktif Dari Sampah Organik Pada Sistem Akuaponik Terhadap Pertumbuhan Dan Keberlangsungan Hidup Ikan Nila (Oreochromis niloticus)
Authors: Nadilla Fara , Wahyuni Nurul , Maulijar Sandry , Fitriani Fitriani 
Published: January 2020

Ikan nila sebagai salah satu komoditas ikan yang potensial dibudidayakan di perairan air tawar. Namun, produktivitas ikan nila di Aceh masih kurang yang disebabkan karena karena keterbasan tambak air tawar. Oleh karena itu dilakukan upaya pembudiayaan ikan nila secara aquaponik dengan menggunakan medium dan filter dari arang aktif. Penelitian ini bertujuan untuk mengetahui pengaruh medim dan filter dari arang aktif pada sistem akuaponik terhadap pertumbuhan dan keberlangsungan hidup ikan nila. Rancangan yang digunakan RAL yang terdiri dari 5 ulangan dan 5 perlakuan. Analisis data menggunakan ANOVA yang dilanjutkan dengan DMRT. Hasil penelitian menunjukkan bahwa terdapat pengaruh penggunaan medium dan filter dari sistem aquaponik terhadap pertumbuhan dan keberlangsungan hidup ikan dengan ketebalan arang aktif 6 cm (P4). Semakin tebal arang aktif yang digunakan sebagai medium dan filter pada sistem aquaponik maka rerata pertumbuhan dan keberlangsungan hidup meningkat.
Knowledge Awareness and Perception towards Prosthodontics Treatment and Services among Medical Students in Jeddah City, Saudi Arabia- A Cross Sectional Pilot Study
Authors: Dr Karunakar Shetty  , Fatima Alzahra Ansari  , Nada Ibrahim Alzurqi  , Arwa Ahmed Althagafi  , Raniyah Abualnour  
Published: January 2020

Prosthodontics is concerned with the design, manufacture and fitting of artificial replacements for teeth and other parts of the mouth. Prosthodontic treatment involves the replacement of missing teeth by means of removable or fixed partial denture, implants, complete dentures, or over dentures. The aim of this study was to evaluate the level of knowledge, perception, awareness and attitude of the medical students towards Prosthodontic treatment. A cross-sectional, Questionnaire based study was conducted among Medical students, covering various Medical colleges in Jeddah city. The study population was selected using cluster random sampling. Altogether 151 undergraduate medical students throughout Jeddah city participated in this study. The data was collected, compiled, and statistically analyzed using SPSS software version 21 and
Chi-square test, t-test, and ANOVA. was performed A total of 151 participants, out of which there were 88 female participants (58.3%) and 63
male participants (41.7%), completed and returned the questionnaire. 134 participants (88.7%) were aware that missing teeth could be replaced
and 17 participants (11.3%) were unaware. 93 participants (61.6%) felt implant Supported Prosthesis is a better Option for replacement of missing teeth and 58 participants (38.4%) did not feel so. 75 participants (49.7%) chose fixed partial denture as an option for replacement of missing teeth whereas 76 participants (50.3%) opted for removable partial denture. 64 participants (42.4%) had fear of prosthodontic replacement and 87 participants (57.6%) had no fear. Within the limitations of this study, following conclusions were drawn: Majority of the medical students was aware that missing teeth could be replaced. Most of them thought Implant supported prosthesis would be a better option for replacing missing teeth. Equal number of participants opted for fixed prosthesis. The most important finding of this study was that majority of the participants showed a lack of knowledge regarding oral hygiene measures with dental prosthesis.
Potentials of crops residues – A case study for the province Vojvodina
Authors: Martinov Milan , Djatkov Djordje , Viskovic Miodrag 
Published: January 2020

Summary
Crop residues are targeted as energy sources and feedstock for diverse products. A six-year lasting investigation, aiming to determine the yield potentials of crop residues of mostly grown field crops wheat, soybean and corn in the province Vojvodina (Serbia), was performed. The three levels of potentials were distinguished: theoretical, technical and sustainable. Two seasonal weather conditions were distinguished – common and dry, and their impact on the biomass yield was analyzed. The yields were expressed as absolute and relative to grain yield since the grain yield is always measured, and is available in national statistics. During common seasons, technical potentials were about 56% for wheat, 45% for soybean and 41 or 51% for the two considered corn stover collection procedures. For dry seasons, the technical potential of all considered crops was reduced to between 30 and 50%. On field remained aboveground residual biomass and its relative (to grain) amount, which was between 43 and 60%, was defined. It was concluded that the defining of sustainable potentials is a very complex task. Besides the aforementioned, measures aimed to preserve soil fertility, some overlooked issues in the literature and practice were listed and commented on.