bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene Regulatory Network Construction Based on a Particle Swarm Optimization of a Long Short-term Memory Network
Authors: Tang Zhenhao , Chai Xiangying , Wang Yu , Cao Shengxian 
Published: November 2019

Background:
The Gene Regulatory Network (GRN) is a model for studying the
function and behavior of genes by treating the genome as a whole, which can reveal the gene
expression mechanism. However, due to the dynamics, nonlinearity, and complexity of gene
expression data, it is a challenging task to construct a GRN precisely. And in the circulating
cooling water system, the Slime-Forming Bacteria (SFB) is one of the bacteria that helps to form
dirt. In order to explore the microbial fouling mechanism of SFB, constructing a GRN for the
fouling-forming genes of SFB is significant.

Objective:
Propose an effective GRN construction method and construct a GRN for the foulingforming
genes of SFB.

Methods:
In this paper, a combination method of Long Short-Term Memory Network (LSTM) and
Mean Impact Value (MIV) was applied for GRN reconstruction. Firstly, LSTM was employed to
establish a gene expression prediction model. To improve the performance of LSTM, a Particle
Swarm Optimization (PSO) was introduced to optimize the weight and learning rate. Then, the
MIV was used to infer the regulation among genes. In view of the fouling-forming problem of
SFB, we have designed electromagnetic field experiments and transcriptome sequencing
experiments to locate the fouling-forming genes and obtain gene expression data.

Results:
In order to test the proposed approach, the proposed method was applied to three datasets:
a simulated dataset and two real biology datasets. By comparing with other methods, the
experimental results indicate that the proposed method has higher modeling accuracy and it can be
used to effectively construct a GRN. And at last, a GRN for fouling-forming genes of SFB was
constructed using the proposed approach.

Conclusion:
The experiments indicated that the proposed approach can reconstruct a GRN
precisely, and compared with other approaches, the proposed approach performs better in
extracting the regulations among genes.
Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway
Authors: Yao Shuang , Zhang Jun , Zhan Yuxia , Shi Yuanping , Yu Yang , Zheng Lu , Xu Ning , Luo Guanghua 
Published: November 2019

Background:Previous clinical studies have suggested that apolipoprotein M (apoM) is involved in glucose metabolism and plays a causative role in insulin sensitivity.Objective:The potential mechanism of apoM on modulating glucose homeostasis is explored and differentially expressed genes are analyzed by employing ApoM deficient (ApoM-/- ) and wild type (WT) mice.Methods:The metabolism of glucose in the hepatic tissues of high-fat diet ApoM-/- and WT mice was measured by a glycomics approach. Bioinformatic analysis was applied for analyzing the levels of differentially expressed mRNAs in the liver tissues of these mice. The insulin sensitivity of ApoM-/- and WT mice was compared using the insulin tolerance test and the phosphorylation levels of protein kinase Akt (AKT) and insulin stimulation in different tissues were examined by Western blot.Results:The majority of the hepatic glucose metabolites exhibited lower concentration levels in the ApoM-/- mice compared with those of the WT mice. Gene Ontology (GO) classification and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that ApoM deficiency affected the genes associated with the metabolism of glucose. The insulin tolerance test suggested that insulin sensitivity was impaired in ApoM-/- mice. The phosphorylation levels of AKT in muscle and adipose tissues of ApoM-/- mice were significantly diminished in response to insulin stimulation compared with those noted in WT mice.Conclusion:: ApoM deficiency led to the disorders of glucose metabolism and altered genes related to glucose metabolism in mice liver. In vivo data indicated that apoM might augment insulin sensitivity by AKT-dependent mechanism.
Facile Preparation of WO3 Nanowires by Bubble-Electrospinning and their Photocatalytic Properties
Authors: Xu Chi , Ling Zhong W. , Qi Zhen , Liu Run , Liu Yu Q. 
Published: November 2019

Background:
As a relatively novel and promising method, the bubble electrospinning is to
fabricate continuous and uniform nanowires using an aerated polymer solution in an electric field. A
large number of oxidized docking nanowires were established on a silicon substrate using the bubble
electrospinning, and then using Tungsten Oxide Ammonium (AMT) as an appropriate calcined air with
the WO3 sources. WO3 production can enhance its catalytic activity, stability, and can raise its rhodamine
B degradation rate as well; the prospect of its wide application.

Methods:
The high aspect ratio of WO3 nanowires is successfully prepared by a lightweight bubble
electrospinning technique using Polyoxyethylene (PEO) and Ammonium-Tungstate (AMT) as the
WO3 precursor after annealing in air at 400, 450 and 500°C, respectively. The products were characterized
by SEM, FTIR, XRD, and TG analysis. This Paper reviews the related patents on bubble electrospinning
and WO3 nanowires.

Results:
The results were shown that the diameter of WO3 nanowires ranges from 2μm to 450nm,
which varies with the calcination temperature. XRD diffraction and infrared spectroscopy showed that
monoclinic crystals were prepared at different calcination temperatures (400, 450 and 500°C).

Conclusion:
In addition, the UV-vis diffuse reflectance spectroscopy showed that the fiber had a
bandgap energy of 2.63 eV after calcination at 450oC, showing excellent photocatalytic activity in the
degradation of Rh B at 245 nm. The preparation of WO3 nanowires by bubble electrospinning method
is a feasible patented technology.
T1 and T2 Mappings in the Early Diagnosis of Achilles Tendinosis
Authors: Tbini Zeineb , Mars Mokhtar , Chelli Mouna 
Published: November 2019

Objective:
The purpose of this study was to compare T1 and T2 relaxation times of normal and pathologic Achilles Tendon (AT) in order to evaluate the ability of these methods to detect early Achilles tendon tendinosis.

Materials and Methods:
Forty-eight subjects were included in this study. Twenty-two subjects were classified as normal group and twenty-six subjects as patient group with tendinosis. MR examination was performed by 3 Tesla scanner using a 12 channel head coil. For relaxation times quantification, we used a sagittal 3D FLASH variable flip angle gradient echo UTE sequence (3D VFA-GE UTE) for T1 mapping and a sagittal Multi Echo Spin Echo sequence (MESE) for T2 mapping. Relaxation times were quantified using two different algorithms written in MATLAB. P value < 0.05 was considered statistically significant.

Results:
Our results showed a statistically significant difference in T1 and T2 values for the normal group compared to the patient group (p<0.05). Mean values of T1 and T2 were 571.69 ms and 24.16 ms for the normal group and 818.10 ms and 32.43 ms for the patient group, respectively. Results reported no correlation (r=0.193) for T1 mapping and a positive significant moderate correlation (r=0.542, p=0.000) for T2 mapping between the normal and patient groups. T1 and T2 showed no correlation in the normal group (r= 0.091, p=0.489) and a positive significant weak correlation in the patient group (r=0.263, p=0.048).

Conclusion:
We concluded that T1 and T2 relaxation times are relatively sensitive to diagnosis degenerative changes in the AT and T1 is more sensitive to AT tendinosis compared to T2.
Comparative Study of Fuzzy PID and PID Controller Optimized with Spider Monkey Optimization for a Robotic Manipulator System
Authors: Agrawal Alka , Goyal Vishal , Mishra Puneet 
Published: November 2019

Background:
Robotic manipulator system has been useful in many areas like chemical
industries, automobile, medical fields etc. Therefore, it is essential to implement a controller for controlling
the end position of a robotic armeffectively. However, with the increasing non-linearity and
the complexities of a robotic manipulator system, a conventional Proportional-Integral-Derivative
controller has become ineffective. Nowadays, intelligent techniques like fuzzy logic, neural network
and optimization algorithms has emerged as an efficient tool for controlling the highly complex nonlinear
functions with uncertain dynamics.

Objective:
To implement an efficient and robustcontroller using Fuzzy Logic to effectively control
the end position of Single link Robotic Manipulator to follow the desired trajectory.

Methods:
In this paper, a Fuzzy Proportional-Integral-Derivativecontroller is implemented whose
parameters are obtainedwith the Spider Monkey Optimization technique taking Integral of Absolute
Error as an objective function.

Results:
Simulated results ofoutput of the plants controlled byFuzzy Proportional-Integral-
Derivative controller have been shown in this paper and the superiority of the implemented controller
has also been described by comparing itwith the conventional Proportional-Integral-Derivative
controller and Genetic Algorithm optimization technique.

Conclusion:
From results, it is clear that the FuzzyProportional-Integral-Derivativeoptimized with
the Spider monkey optimization technique is more accurate, fast and robust as compared to the Proportional-
Integral-Derivativecontroller as well as the controllers optimized with the Genetic algorithm
techniques.Also, by comparing the integral absolute error values of all the controllers, it has
been found that the controller optimized with the Spider Monkey Optimization technique shows
99% better efficacy than the genetic algorithm technique.
Deconstruction of the colonial discourse on the erpangir ku lau ritual in karo society
Authors: Sebayang Vanesia Amelia 
Published: November 2019

Erpangir ku lau is a ritual of cleansing based on Hindu Pemena teachings. This ritual teaches the Karo people to maintain harmonious relations between humans, the forces of nature, and the Creator. However, in the Dutch colonial era, erpangir lau was stopped because it was part of the worship and the practice of magic. The method used in this article is a descriptive qualitative research method that uses theory as a basis. This qualitative descriptive design format embraces phenomenology and post-positivism. This study aims to describe, summarize the various situations or phenomena of social reality in a society that are the object of research, and try to pull that reality to the surface as a description of certain conditions, situations, or phenomena. The findings obtained are that the colonial influence still imprinted on the person of the Karo people even though the occupation had long since ended. Concerning the Dutch colonial discourse, it is necessary to carry out a deconstruction practice to reverse the Karo people's perspective on the erpangir ku lau rites.
Comparison of Live‐Video and Video Demonstration Methods in Clinical Orthodontics Education
Authors: Gorucu‐Coskuner Hande , Atik Ezgi , Taner Tulin 
Published: November 2019

AbstractThe aim of this study was to compare the effectiveness of live‐video and video demonstration methods in training dental students in orthodontic emergency applications. A total of 105 fifth‐year dental students at a dental school in Turkey participated in the study in 2018. A pretest was given to the students to evaluate their level of knowledge about band cementing and re‐bonding of brackets. Subsequently, two clinical applications were demonstrated with either live‐video or video demonstration. During the live‐video demonstration, the lecturer gave information about the steps of the procedure while performing the clinical application on the patient using a camera attached to the loupes. The students were able to see the process on the screens. During the video demonstration, previously recorded videos of those clinical applications were shown, and information was given to students in a classroom. On the next day, posttests were given to the students. The posttest also asked students to give their opinions about both methods. The results showed that the mean posttest scores on the video demonstration were significantly higher than on the live‐video demonstration. However, no significant difference between the demonstration methods was found with regard to increase of scores from pre‐ to posttest. Most students preferred use of the two demonstrations together for education in the clinical orthodontics lecture. This study found that the two demonstration methods had comparable effects on increasing students’ level of knowledge. However, from the students’ perspective, the two should be used together to achieve the highest effect.
Perceived Barriers to Academic Success for International Students Studying Dental Hygiene in the U.S
Authors: Jenkins Susan J. , Boyd Linda D. 
Published: November 2019

AbstractThe number of international students coming to the U.S. for post‐secondary education has been steadily increasing. Prior research has found that international students encounter many barriers to academic success, but this topic has not been previously studied for the discipline of dental hygiene. The aims of this study were to investigate the barriers and challenges to academic success faced by international students in U.S. dental hygiene programs and to explore the students’ thoughts on the value they bring to those programs. The overlapping qualitative methods of semi‐structured focus groups and one‐on‐one interviews with 12 students in three U.S. dental hygiene programs were used for this phenomenological study. In the results, six themes emerged: language proficiency, communication challenges with faculty and patients, ability to adapt to a new educational system, adjusting to cultural differences, feelings of belonging, and the value of diversity. The most significant barrier for the participants was comprehension of the English language. Didactically, these students reported that they needed additional time to study and to process examination questions. This study found that these international students studying dental hygiene in the U.S. had academic challenges similar to international students studying in other disciplines. Dental hygiene educators may need to evaluate their didactic and test‐taking strategies to ensure the academic success of international students.
Preclinical Competency Testing in North American Dental Schools and Opinions About Possible Standardization
Authors: Roberts Eugenia P. , Delapp James A. , Florento Greig , Kramer Robert T. , Brownstein Sheri A. , Stein Amy Buros 
Published: November 2019

AbstractIn the U.S., the Commission on Dental Accreditation (CODA) requires that dental schools use competency‐based assessments and standardized levels of proficiency to ensure that students are prepared for patient care after graduation. No such comprehensive standardized preclinical testing is required in the CODA standards. The aim of this study was to determine the use of preclinical competency assessments for students transitioning from preclinical to clinical education in North American dental schools and respondents’ perceptions of the need for standardization in preclinical testing. An electronic survey was sent to the academic deans of all 76 U.S. and Canadian dental schools in July 2018 asking if the school used competency exams to assess preclinical students prior to entering patient care and, if so, about the type of tests and disciplines tested, student remediation, and reasons for revisions. The survey also asked for the respondents’ perspectives on potential preclinical assessment standardization. Respondents from 28 U.S. and two Canadian schools participated in the survey, for a 39.5% response rate. The majority (92.3%) of respondents said their school considered preclinical competency assessments to be good indicators of students’ readiness for transitioning into patient care, yet 40.0% reported their schools had no comprehensive preclinical testing, and 13.8% had no preclinical testing in endodontics, periodontics, prosthetics, or restorative dentistry. Regarding type of comprehensive preclinical assessment used, 71.4% reported using typodont‐based exams, 46.4% used written comprehensive exams, and 42.9% used objective structured clinical examinations (OSCEs); respondents could select all that applied on this item. Of the respondents whose schools had preclinical competency assessments, 72.4% had a review mechanism in place to evaluate its effectiveness. Overall, this study found that 60% of the participating schools had some form of preclinical testing, but there were no agreed‐upon competencies to determine preclinical dental students’ readiness for safe patient care in their clinical education
Windstorm Resilient Rural Housing: Lessons learned in Temerloh, Malaysia
Authors: Lam Foong Sin , Lee Jer Vui , Ngeow Yeok Meng 
Published: November 2019

In 2019 alone, Temerloh district located in central Peninsular Malaysia has been hit by unpredictable wind storms in localised areas which damaged more than 185 rural homes. This research set out to assess the structural vulnerabilities of damaged rural houses to severe winds in Temerloh and lessons learned from windstorm damage through field surveys of damaged homes between March 2019-August 2019 and supplemented by district-level post-windstorm reconnaissance reports prepared by Malaysia Civil Defense Force (APM) and other information gathered from local government. Results indicate poor performance of structural and non-structural building components in resisting high wind loads due to inadequate design, under-strength of failed building materials and defective construction details. The results of this study could have important implications for government agencies, NGOs, builders, and engineers in assisting rural communities in reconstructing windproof resistant homes and planning for future windstorm risk management efforts specially catered to homeowners in Temerloh.Keywords: Rural housing; Windstorm; Resilience; Malaysia eISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1817
“H.O.P.E.” Hold On Pain Ends: Effects of Reminiscence Therapy on Depression for Elderly with Alzheimer’s Disease
Authors: Azizan Azliyana , Anum Asilah , Alias Noor Amiera 
Published: November 2019

Elderly with Alzheimer's disease may experience various adverse effects on physical and psychological functions, especially depression level. Effective intervention may reduce depressive symptoms. Therefore, the current study aims to investigate the effect of individualized reminiscence therapy on depression levels among the elderly with Alzheimer's disease. The findings showed that individualized-reminiscence therapy significantly affects the elderly with Alzheimer's depression level. In conclusion, reminiscence was beneficial through stressful life changes, reduce depressive symptoms, improving life satisfaction and having a better quality of life among the elderly with Alzheimer's disease.Keywords: Alzheimer’s disease; Depression; Reminiscence therapy eISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1902
Stress Coping Mechanism of Children with Learning Disabilities and Effects on Life Satisfaction of Caregivers
Authors: Alias Noor Amiera , Ghafar Isma Hanis , Azizan Azliyana 
Published: November 2019

The caregiver used variety type of coping mechanism to cope with the challenges in raising children with Learning disabilities (Ld). This study aims to identify the correlation between the coping mechanisms used and life satisfaction. The study found that the reframing (p = .018), acquiring social support (p =. 006)and seeking spiritual support (p = .041) have positive correlation while a passive appraisal (p =. 021), has negative correlation with the life satisfaction. Thus, the selected coping mechanisms used may influence caregivers in having a good life satisfaction across the life span subsequently give a positive propensity upbringing childhood with Ld.Keywords: Caregiver;Learning Disability; Coping mechanism; Life SatisfactioneISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1912
Implementing a Digital HIV Care Navigation Intervention (Health eNav): Protocol for a Feasibility Study
Authors: Arayasirikul Sean , Trujillo Dillon , Turner Caitlin M , Le Victory , Wilson Erin C 
Published: November 2019

BackgroundYoung racial and ethnic minority men who have sex with men (MSM) and trans women are disproportionately affected by HIV and AIDS in the United States. Unrecognized infection, due to a low uptake of HIV testing, and poor linkage to care are driving forces of ongoing HIV transmission among young racial and ethnic minority MSM and trans women. Internet and mobile technologies, in combination with social network-based approaches, offer great potential to overcome and address barriers to care and effectively disseminate interventions.ObjectiveWe describe Health eNavigation (Health eNav), a digital HIV care navigation intervention that extends supportive care structures beyond clinic walls to serve youth and young adults living with HIV who are newly diagnosed, not linked to care, out of care, and not virally suppressed, at times when they need support the most.MethodsThis study leverages ecological momentary assessments for a period of 90 days and uses person-delivered short message service text messages to provide participants with digital HIV care navigation over a 6-month period. We aim to improve engagement, linkage, and retention in HIV care and improve viral suppression. Digital HIV care navigation includes the following components: (1) HIV care navigation, (2) health promotion, (3) motivational interviewing, and (4) digital social support.ResultsRecruitment began on November 18, 2016; enrollment closed on May 31, 2018. Intervention delivery ended on November 30, 2018, and follow-up evaluations concluded on October 31, 2019. In this paper, we present baseline sample characteristics.ConclusionsWe discuss real-world strategies and challenges in delivering the digital HIV care navigation intervention in a city-level, public health setting.International Registered Report Identifier (IRRID)DERR1-10.2196/16406