bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptability of the “MOVEdiabetes” physical activity intervention in diabetes primary care settings in Oman: findings from participants and practitioners
Authors: Alghafri Thamra S , Harthi Saud Al , Al-Ajmi Fatma , Farsi Yahya Al , Craigie Angela M. , Bannerman Elaine , Anderson Annie S. 
Published: March 2020

Abstract
Background Adequate physical activity (PA) is considered essential in diabetes management. However, evidence on the best method of promoting PA within diabetes care is inconclusive. The current work identifies perceptions on the acceptability of Intervention Group Participants (IGP) and Project Officers (POs) about the “MOVEdiabetes” intervention programme aimed at increasing PA in adults with type 2 diabetes in Oman. Methods The “MOVEdiabetes” programme (PA consultations, pedometers and WhatsApp messages) was delivered by the POs (primary health care practitioners) in four primary care centres within a one-year cluster randomised control trial. Recruitment and retention were measured from trial attendance records. Programme satisfaction, appropriateness, and content suitability were assessed using exit surveys for both the IGP (interview based) and POs (self-administered). Open text questions on perceptions to the study programme were also included. Results Participants were randomised to an intervention group (IG, n= 122) or comparison group (CG, n=110). The overall retention rate at three and 12 months was 92.7% [110(90.2%) IG vs 105(95.5%) CG] and 75% [82(67.2%) IG vs 92(83.6%) CG] respectively. Most (87.5%) POs and more than half (59.8%) IGP perceived the programme as very appropriate and many reported that they were “quite/ very satisfied” with the programme (100% PO’s and 86.6% IGP). Two thirds (66.0%) of IGP were very/quite likely to recommend the programme to others. PA consultations, use of pedometers and Whatsapp messages were well perceived by all. Participants recommended the inclusion of dietary advice and PA promotion for the general public. Exploring PA facilities within the community was suggested by POs. Conclusions The “MOVEdiabetes” programme achieved a high retention rate and was perceived as satisfactory and appropriate. Results from this study suggest that it is worthwhile exploring the use of the “MOVEdiabetes” programme in clinical practice and further community links.
Screening for depression in cArDiovascular patients at a tertiary Centre in TrinidAd and Tobago: The SAD CAT study
Authors: Seecheran Naveen , Jagdeo Cathy-Lee , Seecheran Rajeev , Seecheran Valmiki , Persad Sangeeta , Peram Lakshmipatty , Evans Mathew , Edwards Justine , Thackoorcharan Sheri , Davis Britney , Davis Shari , Dawkins Barbrianna , Dayaram Anisha , De Freitas Michelle , Deonarinesingh Tsarina , Dhanai Jiovanna , Didier Cherelle , Baboolal Nelleen 
Published: March 2020

Abstract
Objectives This was an observational, cross-sectional study aimed to screen cardiovascular patients for depression at a tertiary center in Trinidad and Tobago; and to determine any significant associations amongst patients’ demographics, comorbidities, and cardiovascular medications with depressive symptoms. Methods Patients (n=1203) were randomly selected from the cardiology outpatient clinics at the Eric Williams Medical Sciences Complex. After meeting selection criteria, informed consent was obtained, and patients were administered a case report form, which included the Patient Health Questionnaire-9 (PHQ-9). Results The study had a 96% respondent rate, whereby the average age was 62 years old. 47.5% were male, and 52.5% were female. 90.2% of the sample had cardiovascular disease. 25% of the sample had a PHQ-9 score of ≥ 10, with 19.3% having no depressive symptoms. Females, lower levels of education and income were found to be statistically significant at risk for depression (all p-values <0.001). Comorbidities associated with depression included hypertension, prior cerebrovascular events, chronic kidney disease and chronic obstructive pulmonary disease with odds ratios (OR) and 95% confidence intervals (CI) of OR 1.988 (CI 1.414-2.797), OR 1.847 (CI 1.251-2.728), OR 1.872 (CI 1.207-2.902) and OR 1.703 (CI 1.009-2.876) respectively. Only the cardiovascular medication of ticagrelor was found to be significantly associated with depression (p-value <0.001). Conclusion 1 in 4 screened cardiovascular patients displayed significant depressive symptoms with a PHQ-9 ≥ 10. The information acquired from this study may be useful in developing screening protocols that can positively impact adherence and possibly attenuate future events. This study also highlights the importance of implementing a multidisciplinary approach to managing cardiovascular disease and screening for depression. Further studies are required to validate these findings (ClinicalTrials.gov number, NCT03863262).
Low Endemic Frequency of Adenovirus, Rotavirus and Norovirus in Pediatric Diarrhea Samples from Central Iran
Authors: Abbasi Elnaz , Mondanizadeh Mahdieh , Belkum Alex van , Ghaznavi-Rad Ehsanollah 
Published: March 2020

Abstract
Background: Acute viral gastroenteritis is a disorder that affects children on a worldwide scale but mostly in developing countries. Adenoviruses, rotaviruses, and noroviruses are the major viral cause of childhood gastroenteritis. This study is the first to investigate the prevalence of these viruses in diarrhea samples from pediatric patients living in central Iran.Methods: A total of 173 samples of pediatric diarrhea, from May 2015 to May 2016, was included in this descriptive cross-sectional study. The samples were analyzed using in-house developed PCR and reverse transcription (RT) -PCR methods to investigate the prevalence of adeno-, rota- and noroviruses. Results: Out of 173 samples of pediatric diarrhea, eight were shown to contain enteric viruses (4.6%): four of these were adenovirus (2.3%), three were rotavirus (1.7%), and one represented a genogroup II norovirus (0.6%). Most of the positive samples were obtained from children under the age of seven. The most common additional clinical symptoms in pediatric patients with viral agents were fever, vomiting, and abdominal pain. Conclusions: Adenovirus and rotavirus were rarely found as agents responsible for gastroenteritis in central Iran. Although we show that the frequency of viral gastroenteritis is low in this area compared to bacterial gastroenteritis, still longer-term monitoring of all enteropathogenic agents should provide a deeper understanding of the real endemicity and the possible occurrence of unexpected outbreaks of viral enteritis.
Genome-Wide Scan For Common Variants Associated With Intramuscular Fat And Moisture Content In Rainbow Trout
Authors: Ali Ali R. , Al-Tobasei Rafet , Lourenco Daniela , Leed Tim , Kenney Brett , Salem Mohamed 
Published: March 2020

Abstract
Genetic improvement of fillet quality attributes is a priority of the aquaculture industry. Muscle composition impacts quality attributes such as flavor, appearance, texture, and juiciness. Fat and moisture make up about 80% of the tissue weight. The genetic architecture underlying the fat and moisture content of the muscle are still to be fully explored in fish. A 50K gene transcribed SNP chip was used for genotyping 789 fish with available phenotypic data for fat and moisture content. Genotyped fish were obtained from two consecutive generations produced in the NCCCWA growth-selective breeding program. Estimates of SNP effects from weighted single-step GBLUP (WssGBLUP) were used to perform genome-wide association (GWA) analysis to identify quantitative trait loci (QTL) associated with the studied traits. Using genomic sliding windows of 50 adjacent SNPs, 137 and 178 SNPs were identified as associated with fat and moisture content, respectively. Chromosomes 19 and 29 harbored the highest number of SNPs explaining at least 2% of the genetic variation in fat and moisture content. A total of 61 common SNPs on chromosomes 19 and 29 affected the aforementioned traits; this association suggests common mechanisms underlying intramuscular fat and moisture content. Additionally, based on single-marker GWA analyses, 8 and 24 SNPs were identified in association with fat and moisture content, respectively. SNP-harboring genes were primarily involved in lipid metabolism, cytoskeleton remodeling, and protein turnover. This work provides putative SNP markers that could be prioritized and used for genomic selection in breeding programs.
Multiphoton Microscopic Study of the Renal Cell Carcinoma Pseudocapsule: Implications for Tumour Enucleation
Authors: Tan Yi Quan , Tay Wy Keat , Ooi Li Yin , Paulraj Thamboo Thomas , Tiong Ho Yee 
Published: March 2020

Abstract
Background To utilise Multiphoton Microscopy as a novel imaging technique to characterize and quantify collagen at the Renal Cell Carcinoma Pseudocapsule, to assess for both intra-tumoral and inter-tumoral variation of collagen characteristics. MPM combines Second Harmonic Generation and Two Photon Excitation Fluorescence to image extracellular matrix architecture. Methods 20 partial nephrectomy specimen tissues were retrieved, cut into 5‎-micron sections, mounted on slides and deparaffinized. The pseudocapsules were imaged with 2X and 20X objective at selected Regions of Interest. Corresponding clinical information was retrieved. Pseudocapsule thickness was determined. Collagen parameters measured included quantification by the Collagen Area Ratio, and qualitative measurements by the Collagen Fiber Density and Collagen Reticulation Index. Results The boundaries between tumor, PC and normal renal parenchyma were distinguished by Multiphoton Microscopy without the need for staining. In the thickest areas of the pseudocapsule, collagen content and density were quantitatively higher compared to the thinnest areas. Median Collagen Area Ratio was higher in the thickest compared to the thinnest areas of the PC (p=0.01). Clear Cell RCC specimens had a consistently higher Collagen Fiber Density in both the thickest and thinnest areas compared to non-Clear Cell RCC specimens (p=0.02). Conclusions In this study, we demonstrated the ability of Multiphoton Microscopy to quantify collagen characteristics of pseudocapsules without fluorescent labelling. Tumor enucleation for Renal Cell Carcinoma along its Pseudocapsule remains debatable with regards to oncological safety. Even with a complete and intact pseudocapsule, the pseudocapsule is not a homogenous structure, and varies in its thickness and its collagen characteristics within, and between, tumours.
Frozen-thawed embryos generated from successful fresh IVF cycles have higher potential for favorable outcome than frozen-thawed embryos obtained from unsuccessful fresh cycles: A retrospective cohort
Authors: Karavani Gilad , Herzberg Shmuel , Schachter-Safrai Natali , Chill Henry Hillel , Ben-Meir Assaf , Simon Alex 
Published: March 2020

Abstract
Background: Many variables, including woman`s age, embryo quality and endometrial receptivity, influence the success rate of either fresh embryo transfer (ET) or frozen-thawed ET (FT-ET) cycles. The aim of this study is to examine whether the results of a fresh in-vitro fertilization (IVF) cycle correlates with its frozen-thawed embryos transfer outcomes. Methods: A retrospective cohort study conducted in a tertiary medical center single IVF unit between 2014 and 2017. The study population was comprised of women who underwent fresh ET with the remaining embryos frozen using vitrification and at least one consecutive FT-ET cycle. Comparison of FT-ET cycle's details and outcomes were assessed in relation to the outcome of the preceding fresh ET cycle . Results: A total of 599 women underwent fresh ET and at least one consecutive FT-ET cycle. Significantly higher rates of successful FT-ET cycle outcomes were observed in the group of patients with a successful fresh cycle compared to the group with an unsuccessful fresh cycle (48.9% vs. 20.8%, p<0.001). Logistic regression demonstrated an adjusted OR of 5.02 for successful FT-ET after a successful fresh cycle. Conclusions: Frozen-thawed embryos generated from successful fresh IVF cycles have higher potential to implant when compared to frozen-thawed embryos obtained in an unsuccessful fresh cycles.
Efficacy of precise open excision surgery in treatment of osteoid osteoma
Authors: Yuan Yuhao , Long Feng , Liu Qing , Wu Ziyi , He Hongbo , Luo Wei 
Published: March 2020

Abstract
Purpose The aim of this retrospective study was to evaluate the efficacy of precise open excision surgery to treat osteoid osteoma with C-arm assisted precise localization during the operation.Methods From June 2010 to June 2017, patients with osteoid osteoma of the extremities who had undergone treatment by high speed burr grinding, full scratching with curette, and C-arm assisted lesion localization during the operation were analyzed retrospectively. The preoperative and postoperative pain was assessed by the visual analogue scale (VAS) scoring. The patients were followed up regularly, and the advantages, effects, and complications of the therapeutic technique were analyzed.Results The study consisted of 94 patients (59 males, 35 females; mean age, 17.6 ± 8.5 years) and they were followed up for a mean of 38.9 months (range, 24–72 months). All patients were diagnosed with osteoid osteoma by postoperative pathological examination. Follow-up consisted of imaging reexamination and clinical evaluation. If the patients did not take non-steroidal anti-inflammatory drugs (NSAIDs) before the operation, the mean pre-operative VAS score was 6.7, and the mean VAS score of all patients was 0 one month after operation. The mean time for all patients to resume normal daily activities was 14.3 days (range, 10-21 days). There was no recurrence of pain, infection, vascular or nerve injury, and fracture complications during the follow-up. In only one case of distal femur osteoid osteoma (OO), review X-ray found a suspected recurrence 50 months after the primary surgery and subsequently, the patient underwent a second surgery. Till date, the patient has reported no discomfort following the second surgery.Conclusions For treatment of osteoid osteoma, open incision and minimal resection with C-arm assisted tumor localization is still a suitable method, especially for osteoid osteoma located on the surface of the cortical bone.
Compliance with antibiotic prophylaxis guidelines in caesarean delivery: a retrospective, drug utilization study (indication-prescription type) at an Ecuadorian hospital.
Authors: Viamonte Katherine Romero , Tames Adrian Salvent , Correa Rosa Sepùlveda , Manteca María Victoria Rojo , Suárez Ana Martín 
Published: March 2020

Abstract
Background

Preoperative antibiotic prophylaxis is essential for preventing surgical site infection (SSI). The aim of this study was to evaluate compliance with international and local recommendations in caesarean deliveries carried out at the Obstetrics and Gynaecology Service of the Ambato General Hospital, as well as any related health and economic consequences.

Methods

A retrospective indication-prescription drug utilization study was conducted using data from caesarean deliveries occurred in 2018. A clinical pharmacist assessed guidelines compliance based on the following criteria: administration of antibiotic prophylaxis, antibiotic selection, dose, time of administration and duration. The relationship between the frequency of SSI and other variables, including guideline compliance, was analysed. The cost associated with the antibiotic used was compared with the theoretical cost considering total compliance with recommendations. Descriptive statistics, Odds Ratio and Pearson Chi Square were used for data analysis by IBM SPSS Statistics version 25.

Results

The study included 814 patients with an average age of 30.87 ± 5.50 years old. Among the caesarean sections, 68.67% were emergency interventions; 3.44% lasted longer than four hours and in 0.25% of the deliveries blood loss was greater than 1.5 L. Only 69.90% of patients received preoperative antibiotic prophylaxis; however, 100% received postoperative antibiotic treatment despite disagreement with guideline recommendations (duration: 6.75 ± 1.39 days). The use of antibiotic prophylaxis was more frequent in scheduled than in emergency caesarean sections (OR=2.79, P=0.000). Nevertheless, the timing of administration, antibiotic selection and dose were more closely adhered to guideline recommendations. The incidence of surgical site infection was 1.35%, but tended to increase in patients who had not received preoperative antibiotic prophylaxis (OR=1.33, P=0.649). Also, a significant relationship was found between SSI and patient age (Chisq=8.08, P=0.036). The mean expenditure on antibiotics per patient was 5.7 times greater than that the cost derived from compliance with international recommendations.

Conclusions

Surgical antibiotic prophylaxis compliance was far below guideline recommendations, especially with respect to implementation and duration. This not only poses a risk to patients but leads to unnecessary expenditure on medicines. Therefore, this justifies the need for educational interventions and the implementation of institutional protocols involving pharmacists.
The expression patterns and the prognostic roles of PTPN family members in digestive tract cancers
Authors: Chen Jing , Zhao Xu , Yuan Yuan , Jing Jing-jing 
Published: March 2020

Abstract
Background Non-receptor protein tyrosine phosphatases (PTPNs) are a set of enzymes involved in the tyrosyl phosphorylation. The present study intended to clarify the associations between the expression patterns of PTPN family members and the prognosis of digestive tract cancers. Method Expression profiling of PTPN family genes in digestive tract cancers were analyzed through ONCOMINE and UALCAN. Gene ontology enrichment analysis was conducted using the DAVID database. The gene–gene interaction network was performed by GeneMANIA and the protein–protein interaction (PPI) network was built using STRING portal couple with Cytoscape. Data from The Cancer Genome Atlas (TCGA) were downloaded for validation and to explore the relationship of the PTPN expression with clinicopathological parameters and survival of digestive tract cancers. Results Most PTPN family members were associated with digestive tract cancers according to Oncomine, Ualcan and TCGA data. For esophageal carcinoma (ESCA), expression of PTPN1, PTPN4 and PTPN12 were upregulated; expression of PTPN20 was associated with poor prognosis. For stomach adenocarcinoma (STAD), expression of PTPN2, PTPN12 and PTPN22 was upregulated in cancer tissue; pathological grade was significantly correlated with PTPN3, PTPN5, PTPN7, PTPN11, PTPN13, PTPN14, PTPN18 and PTPN23; PTPN20 expression was related with both TNM stage and N stage; PTPN22 was associated with T stage and pathological grade; decreased expression of PTPN5 and PTPN13 was associated with worse overall survival of STAD, while elevated PTPN6 expression indicated better prognosis. For colon adenocarcinoma (COAD), expression of PTPN1, PTPN11, PTPN12 and PTPN13 was upregulated, while expression of PTPN18, PTPN21 and PTPN22 was decreased; expression of PTPN5, PTPN12, and PTPN14 was correlated with TNM stage and N stage; high PTPN5 or PTPN7 expression were associated with increased hazards of death. For rectum adenocarcinoma (READ), expression of PTPN12 was upregulated while PTPN21 and PTPN22 were downregulated. Conclusion Members of PTPN family were differently expressed in digestive tract cancers and matched normal tissues. Correlation were found between PTPN genes and clinicopathological parameters of patients. Expression of PTPN12 was upregulated in all of the ESCA, STAD, COAD and READ. PTPN5 was associated with the clinical features and prognosis of both STAD and COAD.
Analysis of the Natural Electric Field at Different Sea Depths
Authors: Yu Peng , Zhang Jiawei , Cheng Jinfang , Jiang Runxiang 
Published: March 2020

Abstract
The natural electric field at the depth of 0~1500 m in high seas of South China Sea is obtained by using a new type of measuring device. The electric field data in the frequency range of 0.01~0.5 Hz and 0.5~30 Hz are analyzed respectively. The results show that the induced electric field generated by the surface wave (about 0.14 Hz in the experiment) is obvious at the depth of 50 m but can be ignored at the depth greater than 100 m. When the depth increases from 50 m to 1500 m, the peak value of the natural electric field gradually decreases. At the depth of 1000 m, the peak value is 0.04~0.08 uV/m for electric field in 0.01~0.5 Hz, and 0.07~0.1 uV/m for electric field in 0.5~30 Hz. At last, the natural electric field in coastal waters near Sanya City where the water depth is 15 m is measured by means of a sinking device. The results show that, the peak value is about 2~4 uV/m for electric field in 0.01~0.5 Hz and 2 uV/m for electric field in 0.5~30 Hz. By comparing the natural electric field between high seas and coastal waters, we find the latter has a larger peak value than the former at nearly the same water depth. In addition, line spectrum noise often occurs in coastal waters while little line spectrum noise in high seas when the water depth is more than 50 m.
Integrating Data from Multidisciplinary Management of Malignant Pleural Mesothelioma: a cohort study
Authors: Abbott David Michael , Valizia Claudio , Bortolotto Chandra , Tomaselli Stefano , Saracino Laura , Agustoni Francesco , Pozzi Emma , Eleftheriou Dimitrios , Morbini Patrizia , Rinaldi Pietro , Primiceri Cristiano , Filippi Andrea Riccardo , Stella Giulia 
Published: March 2020

Abstract
Background. Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy that most commonly affects the pleural lining of the lungs. MPM has a strong association with asbestos being at least 80% of cases caused by exposure to its biopersistent fibers. Individuals with a chronic exposure to asbestos generally have a 20-40-year latency with no or few symptoms. Such has been the case in the Piedmont and Lombardy regions of Italy where industrial production of materials laden with asbestos, mainly cements, has created a large number of patients. The fibers from this production did not only pose a substantial risk to the workers breathing the fibers, but also to the relatives and the surrounding community. Since 1992, the use of asbestos has been illegal in Italy, but such a long latency means that our center in the university town of Pavia, which is quite close to two former asbestos factories, is currently receiving a large number of patients. Methods. Since 2017 in Pavia, a multidisciplinary team has been collecting data on over 100 patients with MPM, including presentation, pathology type and the diagnostic method used. In addition, imaging data has also been analyzed in 49 patients who underwent CT with contrast prior to treatment. In this study, we bring together the abundant epidemiologic, histologic, radiologic, and other patient data to compare it with similar studies and draw correlations with predictive and prognostic significance. The basic descriptive statistical analysis was conducted through the Excel “Data Analysis” addon package. Results. Overall, the median survival (OS) was of 13.7 months. It was statistically influenced by the detection of pleural effusion at baseline (p<0.0001) and by histology (survival was higher in epidermoid forms (p<0.0001), irrespective of TNM disease stage. Conclusions. Quite unexpectedly, no statistically significant association could be demonstrated between OS and TNM disease stage at diagnosis. This result confirms that the TNM staging system is probably not adequate to manage MPM alone. Multidisciplinary approach to MPM has allowed us to create robust databases that will help guide radiomic projects, treatment research and thus improved patient management