bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immigration, Plenary Powers, and Sovereignty Talk: Then and Now
Authors: Lim Julian 
Published: February 2020

AbstractThis essay surveys the changes and continuities in U.S. immigration law and policy between the Gilded Age and the 1990s–2010s. It points to how the administration of immigration law today is rooted in doctrines established in late nineteenth-century immigration cases. In particular, the essay connects current anxieties over immigration, borders, and national sovereignty to the “plenary power” doctrine that came out of the Supreme Court's decision inChae Chan Ping v. United States(1889). Examining recent federal actions to “secure” the border and enforce immigration law, this essay begins to address the ways in which current policy continues to reflect Gilded Age anxieties about territory, sovereignty, migration, and diverse populations during an era of constantly shifting borders.
Experimental validation of a dual-receiver radar architecture for snowpack monitoring
Authors: Pasian Marco , Espín-López Pedro Fidel , Silvestri Lorenzo , Barbolini Massimiliano , Dell'Acqua Fabio 
Published: February 2020

AbstractMicrowave radars can be used to monitor the internal structure of the snowpack, delivering real-time and non-destructive measurements. Recently, the working principle of an innovative radar architecture able to identify some of the most important snowpack parameters, without external aids, has been demonstrated. A key point of this new architecture is the use of two independent receiving antennas, and one transmitting antenna. This paper presents a comparison between two different implementations, either based on one physical antenna miming two receiving antennas, or based directly on two physical receiving antennas. The different advantages and disadvantages of both solutions are discussed, highlighting the superior accuracy achieved by the implementation based on two physical receiving antennas. Then, this paper also presents the field results achieved by this type of radar architecture, on the grounds of a 5-day experimental campaign that took place in winter 2019 in the Italian Alps on dry snow. The comparison between the radar measurements and the ground truth (manual snowpit analysis, in terms of snowpack depth, dielectric constant, bulk density, and snow water equivalent) is provided. Overall, a root mean square error of around 3.5 cm, 0.05, 27 kg/m3, and 2.5 cm is achieved, respectively.
Time of wild oat (Avena fatua) panicle clipping influences seed viability
Authors: Tidemann Breanne D. , Harker K. Neil , Johnson Eric N. , Willenborg Christian J. , Shirtliffe Steve J. 
Published: February 2020

AbstractWild oat (Avena fatua L.) is one of the most problematic weed species in western Canada due to widespread populations, herbicide resistance, and seed dormancy. In wheat (Triticum aestivum L.), and especially in shorter crops such as lentil (Lens culinaris Medik.), A. fatua seed panicles elongate above the crop canopy, which can facilitate physical cutting of the panicles (clipping) to reduce viable seed return to the seedbank. However, the viability of A. fatua seed at the time of panicle elongation is not known. The objective of this study was to determine the viability of A. fatua seed at successive time intervals after elongation above a wheat or lentil crop canopy. A 2-yr panicle clipping and removal study in wheat and lentil was conducted in Lacombe, AB, and Saskatoon, SK, in 2015 and 2016 to determine the onset of viability in A. fatua seeds at successive clipping intervals. Manual panicle clipping of A. fatua panicles above each crop canopy began when the majority of panicles were visible above respective crop canopies and continued weekly until seed shed began. At the initiation of panicle clipping, A. fatua seed viability was between 0% and 10%. By the last clipping treatment (approximately 6 to 7 wk after elongation), 95% of the A. fatua seeds were viable. Seed moisture and awn angle were not good predictors of A. fatua viability, and therefore were unlikely to provide effective tools to estimate appropriate timing for implementation of A. fatua clipping as a management technique. Based on A. fatua seed viability, earlier clipping of A. fatua is likely to be more effective in terms of population management and easier to implement in shorter crops such as lentil. Investigations into long-term effects of clipping on A. fatua populations are needed to evaluate the efficacy of this management strategy on A. fatua.
Interindividual Differences in Cognitive Functioning Are Associated	with Autobiographical Memory Retrieval Specificity in Older	Adults
Authors: Peters Sarah , Sheldon Signy 
Published: February 2020

Abstract. We examined whether interindividual differences in cognitive functioning among older adults are related to episodic memory engagement during autobiographical memory retrieval. Older adults ( n = 49, 24 males; mean age = 69.93; mean education = 15.45) with different levels of cognitive functioning, estimated using the Montreal Cognitive Assessment (MoCA), retrieved multiple memories (generation task) and the details of a single memory (elaboration task) to cues representing thematic or event-specific autobiographical knowledge. We found that the MoCA score positively predicted the proportion of specific memories for generation and episodic details for elaboration, but only to cues that represented event-specific information. The results demonstrate that individuals with healthy, but not unhealthy, cognitive status can leverage contextual support from retrieval cues to improve autobiographical specificity.
The Stationary Banding Complex and Secondary Eyewall Formation in Tropical Cyclones
Authors: Vaughan Anna , Walsh Kevin J. E. , Kepert Jeffrey D. 
Published: February 2020

Abstract89 GHz passive microwave satellite data are used to develop a five year climatology of the incidence and morphology of the stationary banding complex in tropical cyclones and quantify changes in convective morphology prior to secondary eyewall formation. The stationary banding complex is shown to be present in 39% of passive microwave overpasses. Morphology varies substantially between tropical cyclones, with crossing angles ranging from 0.19° to 61.78° and azimuthal extents from 0.29
to 4.02
radians. Variations in the incidence and geometry of the stationary banding complex are observed in different environmental conditions and geographic locations. For 84 secondary eyewall formation events included in the sample, a stationary banding complex is observed within 6 hr of the secondary eyewall developing in 79% of cases. Within 12 hr prior to secondary eyewall formation, the crossing angle is significantly lower than its sample median, while the azimuthal extent is higher than its sample median. These results demonstrate that secondary eyewall formation is (most) often preceded by the formation and axisymmetrization of a stationary banding complex.
Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells
Authors: Volovetz Josephine , Berezovsky Artem D. , Alban Tyler , Chen Yujun , Lauko Adam , Aranjuez George F. , Burtscher Ashley , Shibuya Kelly , Silver Daniel J. , Peterson John , Manor Danny , McDonald Jocelyn A. , Lathia Justin D. 
Published: February 2020

AbstractGlioblastoma (GBM) is the most prevalent primary malignant brain tumor and is associated with extensive tumor cell infiltration into the adjacent brain parenchyma. However, there are limited targeted therapies that address this disease hallmark. While the invasive capacity of self-renewing cancer stem cells (CSCs) and their non-CSC progeny has been investigated, the mode(s) of migration used by CSCs during invasion is currently unknown. Here we used time-lapse microscopy to evaluate the migratory behavior of CSCs, with a focus on identifying key regulators of migration. A head-to-head migration assay demonstrated that CSCs are more invasive than non-CSCs. Time-lapse live cell imaging further revealed that GBM patient-derived CSC models either migrate in a collective manner or in a single cell fashion. To uncover conserved molecular regulators responsible for collective cell invasion, we utilized the genetically tractable Drosophila border cell collective migration model. Candidates for functional studies were generated using results from a targeted Drosophila genetic screen followed by gene expression analysis of the human homologs in GBM tumors and associated GBM patient prognosis. This strategy identified the highly conserved small GTPase, Rap1a, as a potential regulator of cell invasion. Alteration of Rap1a activity impaired the forward progress of Drosophila border cells during development. Rap1a expression was elevated in GBM and associated with higher tumor grade. Functionally, the levels of activated Rap1a impacted CSC migration speed out of spheres onto extracellular matrix. The data presented here demonstrate that CSCs are more invasive than non-CSCs, are capable of both collective and single cell migration, and express conserved genes that are required for migration and invasion. Using this integrated approach, we identified a new role for Rap1a in the migration of GBM CSCs.
SET7/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21
Authors: Si Wenzhe , Zhou Jiansuo , Zhao Yang , Zheng Jiajia , Cui Liyan 
Published: February 2020

AbstractAlthough the deregulation of lysine methyltransferase (su(var)-3–9, enhancer-of-zeste, trithorax) domain-containing protein 7/9 (SET7/9) has been identified in a variety of cancers, the potential role of SET7/9 and the molecular events in which it is involved in breast cancer remain obscure. Using the online Human Protein Atlas and GEO databases, the expression of SET7/9 was analyzed. Furthermore, we investigated the underlying mechanisms using chromatin immunoprecipitation-based deep sequencing (ChIP-seq) and quantitative ChIP assays. To explore the physiological role of SET7/9, functional analyses such as CCK-8, colony formation, and transwell assays were performed and a xenograft tumor model was generated with the human breast cancer cell lines MCF-7 and MDA-MB-231. Mass spectrometry, co-immunoprecipitation, GST pull-down, and ubiquitination assays were used to explore the mechanisms of SET7/9 function in breast cancer. We evaluated the expression of SET7/9 in different breast cancer cohorts and found that higher expression indicated worse survival times in these public databases. We demonstrated positive effects of SET7/9 on cell proliferation, migration, and invasion via the activation of Runt-related transcription factor 2 (RUNX2). We demonstrate that tripartite motif-containing protein 21 (TRIM21) physically associates with SET7/9 and functions as a major negative regulator upstream of SET7/9 through a proteasome-dependent mechanism and increased ubiquitination. Taken together, our data suggest that SET7/9 has a promoting role via the regulation of RUNX2, whereas TRIM21-mediated SET7/9 degradation acts as an anti-braking system in the progression of breast cancer.
Dictionary learning in Fourier-transform scanning tunneling spectroscopy
Authors: Cheung Sky C. , Shin John Y. , Lau Yenson , Chen Zhengyu , Sun Ju , Zhang Yuqian , Müller Marvin A. , Eremin Ilya M. , Wright John N. , Pasupathy Abhay N. 
Published: February 2020

AbstractModern high-resolution microscopes are commonly used to study specimens that have dense and aperiodic spatial structure. Extracting meaningful information from images obtained from such microscopes remains a formidable challenge. Fourier analysis is commonly used to analyze the structure of such images. However, the Fourier transform fundamentally suffers from severe phase noise when applied to aperiodic images. Here, we report the development of an algorithm based on nonconvex optimization that directly uncovers the fundamental motifs present in a real-space image. Apart from being quantitatively superior to traditional Fourier analysis, we show that this algorithm also uncovers phase sensitive information about the underlying motif structure. We demonstrate its usefulness by studying scanning tunneling microscopy images of a Co-doped iron arsenide superconductor and prove that the application of the algorithm allows for the complete recovery of quasiparticle interference in this material.
Response outcomes gate the impact of expectations on perceptual decisions
Authors: Hermoso-Mendizabal Ainhoa , Hyafil Alexandre , Rueda-Orozco Pavel E. , Jaramillo Santiago , Robbe David , de la Rocha Jaime 
Published: February 2020

AbstractPerceptual decisions are based on sensory information but can also be influenced by expectations built from recent experiences. Can the impact of expectations be flexibly modulated based on the outcome of previous decisions? Here, rats perform an auditory task where the probability to repeat the previous stimulus category is varied in trial-blocks. All rats capitalize on these sequence correlations by exploiting a transition bias: a tendency to repeat or alternate their previous response using an internal estimate of the sequence repeating probability. Surprisingly, this bias is null after error trials. The internal estimate however is not reset and it becomes effective again after the next correct response. This behavior is captured by a generative model, whereby a reward-driven modulatory signal gates the impact of the latent model of the environment on the current decision. These results demonstrate that, based on previous outcomes, rats flexibly modulate how expectations influence their decisions.
Fatigue-resistant adhesion of hydrogels
Authors: Liu Ji , Lin Shaoting , Liu Xinyue , Qin Zhao , Yang Yueying , Zang Jianfeng , Zhao Xuanhe 
Published: February 2020

AbstractThe adhesion of soft connective tissues (tendons, ligaments, and cartilages) on bones in many animals can maintain high toughness (∽800 J m−2) over millions of cycles of mechanical loads. Such fatigue-resistant adhesion has not been achieved between synthetic hydrogels and engineering materials, but is highly desirable for diverse applications such as artificial cartilages and tendons, robust antifouling coatings, and hydrogel robots. Inspired by the nanostructured interfaces between tendons/ligaments/cartilages and bones, we report that bonding ordered nanocrystalline domains of synthetic hydrogels on engineering materials can give a fatigue-resistant adhesion with an interfacial fatigue threshold of 800 J m−2, because the fatigue-crack propagation at the interface requires a higher energy to fracture the ordered nanostructures than amorphous polymer chains. Our method enables fatigue-resistant hydrogel coatings on diverse engineering materials with complex geometries. We further demonstrate that the fatigue-resistant hydrogel coatings exhibit low friction and low wear against natural cartilages.
Predominant regional biophysical cooling from recent land cover changes in Europe
Authors: Huang Bo , Hu Xiangping , Fuglstad Geir-Arne , Zhou Xu , Zhao Wenwu , Cherubini Francesco 
Published: February 2020

AbstractAround 70 Mha of land cover changes (LCCs) occurred in Europe from 1992 to 2015. Despite LCCs being an important driver of regional climate variations, their temperature effects at a continental scale have not yet been assessed. Here, we integrate maps of historical LCCs with a regional climate model to investigate air temperature and humidity effects. We find an average temperature change of −0.12 ± 0.20 °C, with widespread cooling (up to −1.0 °C) in western and central Europe in summer and spring. At continental scale, the mean cooling is mainly correlated with agriculture abandonment (cropland-to-forest transitions), but a new approach based on ridge-regression decomposing the temperature change to the individual land transitions shows opposite responses to cropland losses and gains between western and eastern Europe. Effects of historical LCCs on European climate are non-negligible and region-specific, and ignoring land-climate biophysical interactions may lead to sub-optimal climate change mitigation and adaptation strategies.
Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
Authors: McClelland Levi J. , Zhang Kaiming , Mou Tung-Chung , Johnston Jake , Yates-Hansen Cindee , Li Shanshan , Thomas Celestine J. , Doukov Tzanko I. , Triest Sarah , Wohlkonig Alexandre , Tall Gregory G. , Steyaert Jan , Chiu Wah , Sprang Stephen R. 
Published: February 2020

AbstractRic-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates heterotrimeric G protein alpha subunits (Gα) and serves as an essential Gα chaperone. Mechanisms by which Ric-8A catalyzes these activities, which are stimulated by Casein Kinase II phosphorylation, are unknown. We report the structure of the nanobody-stabilized complex of nucleotide-free Gα bound to phosphorylated Ric-8A at near atomic resolution by cryo-electron microscopy and X-ray crystallography. The mechanism of Ric-8A GEF activity differs considerably from that employed by G protein-coupled receptors at the plasma membrane. Ric-8A engages a specific conformation of Gα at multiple interfaces to form a complex that is stabilized by phosphorylation within a Ric-8A segment that connects two Gα binding sites. The C-terminus of Gα is ejected from its beta sheet core, thereby dismantling the GDP binding site. Ric-8A binds to the exposed Gα beta sheet and switch II to stabilize the nucleotide-free state of Gα.
Concept of a Radiofrequency Device for Osteopenia/Osteoporosis Screening
Authors: Makarov Sergey N. , Noetscher Gregory M. , Arum Seth , Rabiner Robert , Nazarian Ara 
Published: February 2020

AbstractOsteoporosis represents a major health problem, resulting in substantial increases in health care costs. There is an unmet need for a cost-effective technique that can measure bone properties without the use of ionizing radiation. The present study reports design, construction, and testing of a safe, and easy to use radiofrequency device to detect osteoporotic bone conditions. The device uses novel on-body antennas contacting the human wrist under an applied, operator-controlled pressure. For the dichotomous diagnostic test, we selected 60 study participants (23–94 years old, 48 female, 12 male) who could be positively differentiated between healthy and osteopenic/osteoporotic states. The band-limited integral of the transmission coefficient averaged for both wrists, multiplied by age, and divided by BMI has been used as an index. For a 100 MHz frequency band centered about 890–920 MHz, the maximum Youden’s J index is 81.5%. Both the sensitivity and specificity simultaneously reach 87% given the calibration device threshold tolerance of ±3%. Our approach correlates well with the available DXA measurements and has the potential for screening patients at risk for fragility fractures, given the ease of implementation and low costs associated with both the technique and the equipment. The inclusion of radiofrequency transmission data does add supplementary useful information to the available clinical risk factors.
Optimization of culture conditions for differentiation of melon based on artificial neural network and genetic algorithm
Authors: Zhang Qiang , Deng Dandan , Dai Wenting , Li Jixin , Jin Xinwen 
Published: February 2020

AbstractArtificial neural network is an efficient and accurate fitting method. It has the function of self-learning, which is particularly important for prediction, and it could take advantage of the computer’s high-speed computing capabilities and find the optimal solution quickly. In this paper, four culture conditions: agar concentration, light time, culture temperature, and humidity were selected. And a three-layer neural network was used to predict the differentiation rate of melon under these four conditions. Ten-fold cross validation revealed that the optimal back propagation neural network was established with traingdx as the training function and the final architecture of 4-3-1 (four neurons in the input layer, three neurons in the hidden layer and one neuron in the output layer), which yielded a high coefficient of correlation (R2, 0.9637) between the actual and predicted outputs, and a root-mean-square error (RMSE) of 0.0108, suggesting that the artificial neural network worked well. According to the optimal culture conditions generated by genetic algorithm, tissue culture experiments had been carried out. The results showed that the actual differentiation rate of melon reached 90.53%, and only 1.59% lower than the predicted value of genetic algorithm. It was better than the optimization by response surface methodology, which the predicted induced differentiation rate is 86.04%, the actual value is 83.62%, and was 2.89% lower than the predicted value. It can be inferred that the combination of artificial neural network and genetic algorithm can optimize the plant tissue culture conditions well and with high prediction accuracy, and this method will have a good application prospect in other biological experiments.
Enhanced Production of Tetramethylpyrazine in Bacillus licheniformis BL1 through aldC Over-expression and acetaldehyde Supplementation
Authors: Meng Wu , Ding Feng , Wang Rui-Ming , Wang Teng-Fei 
Published: February 2020

AbstractBacillus licheniformis BL1 was used as a starting strain to construct the recombinant tetramethylpyrazine (TMP)-producing strains by over-expression of the α-acetolactate decarboxylase gene (aldC) and α-acetolactate synthase gene (alsS), named BLC, BLS and BLCS, respectively. Then the addition of acetaldehyde was use to enhance the TMP yield in the fermentation process. During microaerobic fermentation, the aldC-overexpressed BLC strain produced 43.75 g TMP/L which was 15.47% higher than the TMP in culture yielded using the initial BL1 strain. Furthermore, the acetoin yield as TMP precursor similarly rose by 23.06% in BLC recombinant strain. In contrast, the 2,3-BD increased by 23.2% in the recombinant BLCS. TMP produced by BL1 could be bolstered via the supplementation of the acetaldehyde in fermentation medium. This method also has the same effect on the BLC strain.
Magnetic compass of garden warblers is not affected by oscillating magnetic fields applied to their eyes
Authors: Bojarinova Julia , Kavokin Kirill , Pakhomov Alexander , Cherbunin Roman , Anashina Anna , Erokhina Maria , Ershova Maria , Chernetsov Nikita 
Published: February 2020

AbstractThe magnetic compass is an important element of the avian navigation system, which allows migratory birds to solve complex tasks of moving between distant breeding and wintering locations. The photochemical magnetoreception in the eye is believed to be the primary biophysical mechanism behind the magnetic sense of birds. It was shown previously that birds were disoriented in presence of weak oscillating magnetic fields (OMF) with frequencies in the megahertz range. The OMF effect was considered to be a fingerprint of the photochemical magnetoreception in the eye. In this work, we used miniaturized portable magnetic coils attached to the bird’s head to specifically target the compass receptor. We performed behavioural experiments on orientation of long-distance migrants, garden warblers (Sylvia borin), in round arenas. The OMF with the amplitude of about 5 nT was applied locally to the birds’ eyes. Surprisingly, the birds were not disoriented and showed the seasonally appropriate migratory direction. On the contrary, the same birds placed in a homogeneous 5 nT OMF generated by large stationary coils showed clear disorientation. On the basis of these findings, we suggest that the disruption of magnetic orientation of birds by oscillating magnetic fields is not related to photochemical magnetoreceptors in their eyes.