bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONCENTRAÇÃO E TERRITORIALIZAÇÃO DA PRODUÇÃO INOVADORA NO BRASIL: UMA ANALISE A PARTIR DO CONCEITO DE CONDIÇÕES GERAIS DE PRODUÇÃO
Authors: Tunes Regina 
Published: May 2020

Resumo: O artigo apresenta o debate da Geografia da Inovação no Brasil na primeira década do século XXI a partir da análise da concentração espacial e territorialização da produção inovadora na metrópole paulista. Entende-se no debate que concentração e territorialização são dois processos diferentes, mas que no caso em análise ocorrem de forma simultânea e ambos estão diretamente relacionados com as condições gerais de produção que são seletivamente produzidas e dão a possibilidade da reprodução do capital inovador na região da metrópole paulista.Palavras-chave: Geografia da Inovação; Condições gerais de produção; Concentração Espacial; Territorialização da produção; Metrópole. Concentration and territorialization of innovative production in Brazil: an analysis from the concept of general production conditionsAbstract: The article presents the debate on the Geography of Innovation in Brazil in the first decade of the 21st century from the date of the spatial and territorial research of innovative production in the metropolis of São Paulo. The debate is understood to mean that concentration and territoriality are two different processes, but that they have no case of analysis simultaneously and simultaneously, with the general characteristics of production that are executed in a practical way of the metropolis of São Paulo.Keywords: Geography of Innovation; General conditions of production; Spatial Concentration; Territorialization of production; Metropolis. Concentración y territorialización de la producción innovadora en Brasil: un análisis desde el concepto de condiciones generales de producciónRésumé: El artículo presenta el debate de la Geografía de la Innovación en Brasil en la primera década del siglo XXI a partir del análisis de la concentración espacial y la territorialización de la producción innovadora en la metrópoli de São Paulo. En el debate se entiende que la concentración y la territorialización son dos procesos diferentes, pero en este caso ocurren simultáneamente y ambos están directamente relacionados con las condiciones generales de producción que se producen selectivamente y dan la posibilidad de reproducir capital innovador en la región de la metrópoli de São Paulo. Palabras-clave: Geografía de innovación; Condiciones generales de producción; Concentración espacial; Territorialización de la producción; Metrópolis.
Ministerio Público de la Defensa de la Ciudad Autónoma de Buenos Aires (2017). La revolución de las mariposas. A diez años de La gesta del nombre propio
Authors: Romero Marchesini Natalia 
Published: May 2020

Revisión del libro La revolución de las mariposas. A diez años de La gesta del nombre propio del Ministerio Público de la Defensa de la Ciudad Autónoma de Buenos Aires
Left atrial appendage occlusion in patients with atrial fibrillation and large prevalence of prior intracranial bleeding
Authors: Barocelli Federico , Coli Stefano , Crocamo Antonio , Guidorossi Angela , Cattabiani Maria A. , Preti Francesca , Bosi Davide , Spaziani Cristina , Lina Daniela , Menozzi Alberto , Solinas Emilia , Pelà Giovanna , Vignali Luigi 
Published: May 2020

Background
Left atrial appendage occlusion (LAAO) represents an alternative approach for the prevention of cardioembolic stroke in patients with nonvalvular atrial fibrillation (NVAF) and contraindication for oral anticoagulation (OAC). The aim of our study was to analyse the outcomes in patients treated with LAAO, with a focus on cases with previous intracranial bleeding.

Methods
Sixty patients with NVAF underwent LAAO (75.4 ± 9 years); mean CHA2DS2-VASc was 4.4 ± 1.7, mean HAS-BLED 3.2 ± 0.9. Thirty-two patients (53.3%) reported previous intracranial bleeding. Ischaemic and bleeding events recorded during follow-up were compared with expected event rates according to CHA2DS2-VASc and HAS-BLED scores.

Results
Device implantation was successful in 58 patients (96.7%). The antiplatelet therapy was tailored according to patients’ bleeding risk. During follow-up (2.32 ± 1.5 years) 3 ischaemic strokes and 1 transient ischaemic attack occurred, versus 13 total expected thromboembolic events (P = 0.033); 5 major bleedings were observed, versus 7 expected ones, if the patients were under OAC. Considering the combined endpoint (thromboembolic and major bleeding events) 9 events were observed versus 20 expected major events (P = 0.031). In the prespecified subgroup of patients with previous intracranial bleeding, two ischaemic strokes and one transient ischaemic attack were observed during follow-up versus six total expected thromboembolic events; no intracranial bleeding recurrence was recorded. Regarding the combined endpoint four major events were recorded versus nine expected ones.

Conclusion
LAAO is an efficient and safe option for the prevention of cardioembolic stroke in patients with NVAF, high thromboembolic risk and contraindication to OAC, particularly in patients with previous intracranial bleeding.
International Framework for Red Flags for Potential Serious Spinal Pathologies
Authors: Finucane Laura M. , Downie Aron , Mercer Christopher , Greenhalgh Susan M. , Boissonnault William G. , Pool-Goudzwaard Annelies L. , Beneciuk Jason M. , Leech Rachel L. , Selfe James 
Published: May 2020

Synopsis The International Federation of Orthopaedic Manipulative Physical Therapists (IFOMPT) led the development of a framework to help clinicians assess and manage people who may have serious spinal pathology. While rare, serious spinal pathology can have devastating and life-changing or life-limiting consequences, and must be identified early and managed appropriately. Red flags (signs and symptoms that might raise suspicion of serious spinal pathology) have historically been used by clinicians to identify serious spinal pathology. Currently, there is an absence of high-quality evidence for the diagnostic accuracy of most red flags. This framework is intended to provide a clinical-reasoning pathway to clarify the role of red flags. J Orthop Sports Phys Ther 2020;50(7):350–372. Epub 21 May 2020. doi:10.2519/jospt.2020.9971
Simulating Chalcogen Bonding Using Molecular Mechanics: A Pseudoatom Approach to Model Ebselen.
Authors: Fellowes Thomas , WHITE JONATHAN 
Published: May 2020

The organoselenium compound ebselen has recently been investigated as a treatment for COVID-19, howeverefforts to model ebselen in silico have been hampered by the lack of a efficient and accurate method to assessits binding to biological macromolecules. We present here a Generalized Amber Force Field modification whichincorporates classical parameters for the selenium atom in ebselen, as well as a positively charged pseudoatom tosimulate the sigma?-hole, a quantum mechanical phenomenon that dominates the chemistry of ebselen. Our approachis justified using an energy decomposition analysis of a number DFT optimised structures, which shows that the?sigma-hole interaction is primarily electrostatic in origin. Finally, our model is verified by conducting MD simulationson a number of simple complexes, as well the clinically relevant SOD1, which is known to bind to ebselen.
Paydaşlarına göre örgün eğitimle birlikte hafızlık uygulamasının değerlendirilmesi
Authors: UĞUR Elif , OSMANOĞLU Cemil 
Published: May 2020

Müslüman toplumlarda hafızlık eğitimine büyük önem verilmiştir. İslam dünyasında Kur’an’ın öğrenilmesi-öğretilmesi ve bu çerçevede oluşan Kur’an ilimleri noktasında birçok eser telif edilmiş, bu eserler zamanla daru’l-kur’an ve daru’l- huffaz’ların müfredatını meydana getirmiştir. Selçuklu ve Osmanlı’da daru’l-kur’an ve daru’l-huffaz’larda devam eden hafızlık eğitimi, Cumhuriyet sonrası Türkiye’de Diyanet İşleri Başkanlığı’nın sorumluluğunda, Kur’an kurslarında varlığını sürdürmüştür. Günümüzde hafızlık eğitiminde yapılan yeni düzenlemeyle Milli Eğitim Bakanlığı’na bağlı İmam-Hatip Ortaokullarında örgün eğitimle birlikte hafızlık projeleri uygulanmaya başlanmıştır. Proje dâhilinde öğrencilerin okula ara vermeden hafızlıklarını tamamlamaları ve pekiştirmeleri ön görülmüştür. Bu uygulamanın yanında Diyanet İşleri Başkanlığı son yıllarda farklı hafızlık projeleri de geliştirmeye çalışmaktadır. Bunlardan birisi de İlahiyat lisans eğitimiyle birlikte hafızlık uygulamasıdır. Bu uygulama ile öğrenciler eğitimlerine ara vermeden hafızlık eğitimi alabilmektedirler. Bu araştırmada işte yukarıda sözü edilen iki uygulamanın idareci, öğretici ve öğrenci gözüyle durumunu ortaya koymak amaçlanmıştır. Örgün eğitimle birlikte hafızlık uygulamasının paydaşların görüşleri ışığında incelenmesi, bu kapsamda verilen hafızlık eğitiminin veriler ışığında değerlendirilmesi, bu tür uygulamaların bilimsel bir bakış açısıyla geliştirilmesi açısından oldukça önemlidir. Nitel araştırma yöntemi kullanılan bu çalışmada veriler mülakat tekniği ile elde edilmiştir. Yarı yapılandırılmış görüşme formunun kullanıldığı çalışmada, idareci, öğretici ve öğrencilerden oluşan 26 kişilik çalışma gurubundan elde edilen verilerle ortaokul ve ilahiyat lisans eğitimiyle hafızlık uygulamasının farklı boyutlarını aydınlatıcı bilgiler elde edilmiştir. Araştırma sonucunda örgün eğitimle birlikte hafızlık uygulamasının önemli bulunduğu, buna karşılık projeye öğrenci seçiminden öğrenci başarısını değerlendirmeye, personel niteliklerinden rehberlik faaliyetlerine kadar birçok konuda çeşitli aksaklıklar yaşandığı anlaşılmış bunların iyileştirilmesi noktasında bilimsel verilere dayalı, paydaş memnuniyeti ve iş birliğini, kurumlar arası eşgüdüm ve koordinasyonu esas alan bir yaklaşımın daha anlamlı olacağı vurgulanmıştır.
PENERAPAN PERANGKAT PEMBELAJARAN MODEL QUANTUM LEARNING TERHADAP HASIL BELAJAR SISWA KELAS X SMA KARTIKA XIII-1 AMBON
Authors: Amir Adhar , Salmanu S I. A , Arini Ine 
Published: May 2020

Background: Quantum learning model is a set of learning models that are proven to be effectively applied in schools. This study aims to determine the application of biological learning devices using quantum learning models to the learning outcomes of virus material can improve student learning outcomes in class X SMA Kartika XIII-1 Ambon.
Method: This type of research is descriptive type. The population in this study is SMA Kartika XIII-1 Ambon. The samples in this study were all students of class X MIA SMA Kartika XIII-1 Ambon, amounting to 16 students. The data obtained were analyzed descriptively and inferentially.
Results: In the cognitive aspect of 16 students there were 5 students with a percentage (31.25%) getting grades (85-100) with very good qualifications and 11 students with a percentage (68.75%) getting grades (77-84) with qualifications well. Affective aspects, where at intervals of 77-84 there are 13 students (81.25%), 3 students score at intervals of 70-76 (18.75%) who have this value with complete qualifications. Psychomotor aspects, where at intervals of ≥70 there are 16 students (100%) who have grades with complete qualifications.
Conclusion: The level of student success viewed from cognitive, affective, and psychomotor aspects. This is in accordance with the analysis data and the percentage data obtained at the initial test was 65.31% while the final percentage of the test produced was 79.68%.
Electron microscopic changes of lymph nodes during correction of sodium glutamate action by melatonin
Authors: Harapko T.V. 
Published: May 2020

The effect of monosodium glutamate on lymphoid organs remains insufficiently studied. Also, no less relevant is the issue of correction of changes caused by the action of monosodium glutamate. The aim of the study was to study the electron microscopic changes in the parenchyma of the lymph nodes of rats under the action of monosodium glutamate for six weeks and during correction with melatonin. The experimental study was performed on 66 white male and female rats of reproductive age. The structure of mesenteric lymph nodes of white rats under the conditions of physiological norm at the electron microscopic level was studied in 10 intact animals. Experimental animals were divided into 4 groups, each with 10 animals. The control was 16 white rats, which instead of a high-calorie diet (HCD) received a standard diet of vivarium. HCD was achieved by adding to the diet of monosodium glutamate at a dose of 0.07 g/kg body weight of rats. The dose of melatonin was 10 mg/kg body weight of rats, administered orally daily at the same time in the afternoon. The electron microscopic structure of the mesenteric lymph nodes of male and female rats of reproductive age of the intact and control groups corresponds to the species norm. The study showed that monosodium glutamate causes changes in the parenchyma of the lymph nodes as in alimentary obesity. After six weeks of HCD, the number of apoptically altered lymphocytes increases. That part of lymphocytes, which has no signs of karyorrhexis or karyolysis, has a karyolemma with deep intussusception, the cytoplasm is enlightened, the tubules of the granular endoplasmic reticulum in cells with signs of edema, dilated, mitochondrial ridges swollen, damaged. There are profound destructive changes in the cellular composition of the organ and violations at the level of all parts of the vascular bed. After six weeks of melatonin correction, the number of macrophages and plasma cells decreased, in some lymphocytes the nucleolus is not clearly expressed, the karyolemma is uneven, the cytoplasm is enlightened, the number of osmophilic (fatty) inclusions decreases both in the intercellular space and in the cytoplasm of the cell. Therefore, the introduction of melatonin led to a significant restoration of the structural organization, and hence the function of this organ.
The Effect of Vitamin D Replacement on Patient with Subclinical Hypothyroidism: A Pilot Randomized Clinical Trial
Authors: Pezeshki Babak , Ahmadi Ali , Karimi Aliasghar 
Published: May 2020

Background: Subclinical hypothyroidism (SCH) is characterized by an elevated Thyroid Stimulating Hormone (TSH) with a normal T4. The prevalence of Vitamin D deficiency in patients SCH is high. Some studies suggested that Vitamin D supplements could be reduced serum concentration of TSH so improve SCH and prevent overt hypothyroidism. This study aims to explore the effect of vitamin D replacement on subclinical hypothyroidism. Materials and Methods: Fifty-nine patients, diagnosed with both subclinical hypothyroidism and Vitamin D deficiency by the Endocrinology outpatient clinics between January 2018 and March 2019, were included in this trial. The patients with overt hypothyroidism, cardiovascular risk factors, or positive TPO antibody, abnormal T4, and pregnant women were excluded from this study. The 40 subjects were investigated who received vitamin D supplements for two months. Analyses were conducted through paired-samples t-test and independent-samples t-test using SPSS 24 (Armonk, NY: IBM Corp). Results: The mean serum levels of TSH was decreased from 6.89 mIU/l in the pre-test to 3.34 mIU/l in the post-test, and the difference was found to be statistically significant at P<0.001. Conclusion: We found that the TSH mean level significantly dropped through the use of vitamin D supplements. Thus, it is recommended that all the patients with subclinical hypothyroidism be screened and treated with vitamin D supplements. [GMJ.2020;9:e1592]
Efficacy of intraarterial superselective indocyanine green videoangiography in cerebral arteriovenous malformation surgery in a hybrid operating room
Authors: Shimada Kenji , Yamaguchi Tadashi , Miyamoto Takeshi , Sogabe Shu , Korai Masaaki , Okazaki Toshiyuki , Kanematsu Yasuhisa , Satomi Junichiro , Nagahiro Shinji , Takagi Yasushi 
Published: May 2020

OBJECTIVE
Although intravenous indocyanine green (ICG) videoangiography has been reported to be useful when applied to cerebral arteriovenous malformation (AVM) surgery, the ICG that remains after the procedure makes it difficult to understand the anatomy, to evaluate nidus blood flow changes, and to repeat ICG videoangiography within a short time. Intraarterial ICG videoangiography has emerged as a way to overcome these limitations. The current study presents the results of intraarterial ICG videoangiography undertaken in patients with cerebral AVMs.

METHODS
Intraarterial ICG videoangiography was performed in 13 patients with cerebral AVMs. Routine intraoperative digital subtraction angiography at the authors’ institution is performed in a hybrid operating room during AVM surgery and includes the added step of injecting ICG to the contrast medium that is administered through a catheter.

RESULTS
Predissection studies were able to visualize the feeder in 12 of 13 cases. The nidus was visualized in 12 of 13 cases, while the drainer was visualized in all cases. After total dissection of the nidus, there was no ICG filling in the drainers found in any of the cases. Washout of the ICG took 4.4 ± 1.3 seconds in the feeders, 9.2 ± 3.5 seconds in the drainers, and 20.9 ± 3.4 seconds in all of the vessels. Nidus flow reduction was confirmed during dissection in 9 of 9 cases. Flow reduction was easy to recognize due to each span being very short. Color-encoded visualization and objective data obtained by Flow 800 analysis reinforced these findings.

CONCLUSIONS
The results showed that intraarterial ICG videoangiography was more useful than intravenous ICG videoangiography in cerebral AVM surgery. This was especially effective in the identification of the feeder, nidus, and drainer and in the assessment of the flow dynamics of the nidus. Use of Flow 800 made it simpler and easier to evaluate these findings.
Resolution of neonatal posthemorrhagic ventricular dilation coincident with patent ductus arteriosus ligation: case report
Authors: Vanstrum Erik B. , Borzage Matthew T. , Chu Jason K. , Wang Shuo , Rea Nolan , McComb J. Gordon , Krieger Mark D. , Chiarelli Peter A. 
Published: May 2020

Preterm infants commonly present with a hemodynamically significant patent ductus arteriosus (hsPDA). The authors describe the case of a preterm infant with posthemorrhagic ventricular dilation, which resolved in a temporally coincident fashion to repair of hsPDA. The presence of a PDA with left-to-right shunting was confirmed at birth on echocardiogram and was unresponsive to repeated medical intervention. Initial cranial ultrasound revealed periventricular-intraventricular hemorrhage. Follow-up serial ultrasound showed resolving intraventricular hemorrhage and progressive bilateral hydrocephalus. At 5 weeks, the ductus was ligated with the goal of improving hemodynamic stability prior to CSF diversion. However, neurosurgical intervention was not required due to improvement of ventriculomegaly occurring immediately after PDA ligation. No further ventricular dilation was observed at the 6-month follow-up.Systemic venous flow disruption and abnormal patterns of cerebral blood circulation have been previously associated with hsPDA. Systemic hemodynamic change has been reported to follow hsPDA ligation, although association with ventricular normalization has not. This case suggests that the unstable hemodynamic environment due to left-to-right shunting may also impede CSF outflow and contribute to ventriculomegaly. The authors review the literature surrounding pressure transmission between a PDA and the cerebral vessels and present a mechanism by which PDA may contribute to posthemorrhagic ventricular dilation.
Expanding Meaningfulness: Perceptions and Strategy Use of Chinese International Graduate Students in Disciplinary Reading
Authors: Wang Yang 
Published: May 2020

This qualitative case study explored two Chinese international graduate students’ beliefs about their reading and reading processes. The researcher interviewed the participants, asked them to read aloud, analyzed their reading using miscue analysis, and then discussed their reading with them using retrospective miscue analysis (RMA). The researcher found that readers’ beliefs were not static and text difficulty influenced the students’ reading beliefs and strategy use. Through RMA, both students became aware of their respective reading processes and they both became more confident as readers. This study suggests that RMA is an effective tool for English-as-an-additional language graduate students, as it helps in the construction of meaning and the improvement of disciplinary literacy skills.
Language Revitalisation in Gaelic Scotland
Authors: Dunmore Stuart 
Published: May 2020

Situated within the interrelated disciplines of applied sociolinguistics and the sociology of language, this book explores the language use and attitudinal perceptions of a sample of 130 adults who received Gaelic-medium education (GME) at primary school, during the first years of that system’s availability in Scotland. The school is viewed by policymakers as a crucial site for language revitalisation in such diverse contexts as Hawai’i, New Zealand and the Basque Country – as well as throughout the Celtic-speaking world. In Scotland, GME is seen as a key area of language development, regarded by policymakers as a strategic priority for revitalising Gaelic, and maintaining its use by future generations of speakers. Yet theorists have stressed that school-based policy interventions are inadequate for realising this objective in isolation, and that without sufficient support in the home and community, children are unlikely to develop strong identities or supportive ideologies in the language of their classroom instruction. For the first time, this book provides an in-depth assessment of language use, ideologies and attitudes among adults who received an immersion education in a minority language, and considers subsequent prospects for language revitalisation in contemporary society. Based on detailed analyses using mixed methods, the book offers empirically grounded suggestions for individuals and policymakers seeking to revitalise languages internationally.
Standing with the Earth: From Cosmopolitical Exhaustion to Indigenous Solidarities
Authors: Glowczewski Barbara 
Published: May 2020

This essay shows that the exhaustion of the earth, of certain ontologies, and of our creative forces, are all interconnected, just as the ethico-aesthetic responses to this exhaustion are inseparable from cosmopolitics. More and more activist movements struggling against the destruction of their living environments – especially because of the extractive industries that accelerate the climate change and poison the water and the air, – look for alliance with and inspiration from Indigenous people, such as Aboriginal Australians, whose vision of the Earth is not to deny nature on the pretext that it would have succumbed to human technologies. This article proposes to respond to the reduction of ontologies in anthropology with a “slow anthropology” that would be “standing with the Earth”, a slow anthropology based on a field experience, ecosophically inspired by visions and creativity of Indigenous peoples and of their allies, and by the Science Fiction according to Haraway, Stengers and Meillassoux. First published in 2017.