bluuebunny/crossref_metadata_2025_split huggingface dataset:
<p><strong><em>Spathoglottis arunachalensis</em></strong><strong> (Orchidaceae), a new species from Arunachal Pradesh, India</strong></p>
Authors: TSERING JAMBEY , PRASAD KOTHAREDDY 
Published: February 2020

A new species of Spathoglottis, S. arunachalensis (Orchidaceae), from Sessa Orchid Sanctuary in Arunachal Pradesh is described and illustrated. Morphologically, the new species is allied to S. ixioides but differs in many attributes which are discussed here. An updated key for Indian Spathoglottis is also provided for easy identification.
Challenges faced by peer support workers during the integration into hospital-based mental health-care teams: Results from a qualitative interview study
Authors: Otte Ina , Werning Anna , Nossek Alexa , Vollmann Jochen , Juckel Georg , Gather Jakov 
Published: February 2020

Background: Being aware of the challenges that may occur during the implementation of peer support work in psychiatry is important to facilitate the integration of peer support workers (PSWs) into multidisciplinary mental health-care teams. Aim: The purpose of this study is to explore the challenges faced by PSWs during their integration into hospital-based mental health-care teams. Methods: Qualitative content analysis of nine open-ended, semi-structured interviews with PSWs is undertaken in five adult psychiatric hospitals in North Rhine-Westphalia, Germany. Results: The analysis of the data revealed three themes: (1) ‘Pioneers and the pressure to succeed’; (2) ‘a colleague, a rival or yet another patient?’ and (3) ‘sharing of information, boundaries and professionalism’. All three themes relate to several concrete challenges on different systemic levels and have the potential to impede the PSWs’ integration process. Conclusion: Specific implementation strategies which address potential barriers on the different systemic levels should be developed and applied prior to the start of the integration of PSWs into multidisciplinary mental health-care teams.
The true axial shoulder projection: Diagnostic aid for acromioclavicular joint dislocation?
Authors: Jassim SS , Clough R , Yarashi T , Carlos A , Di Mascio L 
Published: February 2020

Introduction Acromioclavicular joint dislocations are common. Differentiating between horizontal and vertical instability is challenging, but possible to diagnose on axial radiographs. No clear consensus for axial radiograph parameters currently exists. We aim to establish a reproducible technique to assess whether an axial radiograph represents a true axial view of the shoulder. Methods One hundred CT scans of normal uninjured shoulders were examined using multiplanar reformatting to assess the distance between the anterior glenoid (reference line) and anterior-most aspect of the acromion in the axial plane. Measurements were repeated and performed by multiple observers to give of intra- and inter-observer reliability. Results The mean distance from the anterior acromion to the reference line was −2.6 mm (i.e. posteriorly placed) (SD = 5.8 mm, range −16.9–13.2 mm). Most (89%) of the measurements were between 9 and −9 mm to the reference line. Intra-observer reliability was high with Cronbach’s α measurement as 0.997. Inter-observer reliability gave a Cronbach’s α measurement of 0.959. Conclusion When the anterior aspect of the acromion lies within 10 mm either side of a line parallel to the scapula blade at the anterior aspect of the glenoid on an axial radiograph, it represents a true axial projection of the glenohumeral joint (GHJ). Level of evidence: IV, Case series
Improving the standard of care for patients with spondyloarthritis-related immune inflammatory conditions: results of a Delphi study and proposal for early detection
Authors: Coto Pablo , Riestra Sabino , Rozas Paloma , Señaris Ana , Queiro Rubén 
Published: February 2020

Background: Our objective was to provide consensus recommendations on the optimal management of the immune-mediated inflammatory diseases (IMIDs) seen in patients with spondyloarthritis (SpA) using a multidisciplinary approach, and to develop a simple tool to help earlier recognition and referral of coexisting IMIDs in patients who already have one type of IMID. Methods: A total of 28 experts in the multidisciplinary management of the SpA-associated IMIDs assessed two questionnaires: one with statements focused on the multidisciplinary management of IMIDs, and a second questionnaire focused on questions useful for early recognition and referral. Panelists assessed the statements with a 9-point ordinal scale (1 = strongly disagree, 9 = strongly agree) using a modified Delphi methodology. Results: Consensus was reached on 72 out of the 82 statements (87.8%). Panelists agreed that the multidisciplinary approach to IMIDs is not sufficiently developed. The creation of multidisciplinary IMID units might be necessary. These units might focus primarily on patients with two or more coexisting IMIDs, or on IMIDs that are especially complex from a diagnostic or therapeutic point of view. Specialists who attend to patients with IMIDs should perform a screening for other coexisting IMIDs. A simple tool to help earlier recognition and referral of coexisting IMIDs is proposed. Conclusions: There is a need to improve care for patients with SpA-associated IMIDs. We provide expert recommendations to guide the adoption of a multidisciplinary approach for these cases, and a simple tool that may be useful for earlier recognition of coexisting IMIDs.
A meta-analysis of the medium- and long-term effects of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass
Authors: Gu Lihu , Huang Xiaojing , Li Shengnan , Mao Danyi , Shen Zefeng , Khadaroo Parikshit Asutosh , Ng Derry Minyao , Chen Ping 
Published: February 2020

Abstract
Background
Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are two representative bariatric surgeries. This study aimed to compare the effects of the LSG and LRYGB based on high-quality analysis and massive amount of data.

Methods
For this study databases of PubMed, Web of Science, EBSCO, Medline, and Cochrane Library were searched for articles published until January 2019 comparing the outcomes of LSG and LRYGB.

Results
This study included 28 articles. Overall, 9038 patients (4597, LSG group; 4441, LRYGB group) were included. The remission rate of type 2 diabetes mellitus (T2DM) in the LRYGB group was superior to that in the LSG group at the 3-years follow-up. Five-year follow-up results showed that LRYGB had an advantage over LSG for the percentage of excess weight loss and remission of T2DM, hypertension, dyslipidemia, and abnormally low-density lipoprotein.

Conclusions
In terms of the long-term effects of bariatric surgery, the effect of LRYGB was better than of LSG.
The effects of diagnosis-related groups payment on hospital healthcare in China: a systematic review
Authors: Zou Kun , Li Hong-Ying , Zhou Die , Liao Zai-Jun 
Published: February 2020

Abstract
Background
There has been a growing interest in using diagnosis-related groups (DRGs) payment to reimburse inpatient care worldwide. But its effects on healthcare and health outcomes are controversial, and the evidence from low- and middle- income countries (LMICs) is especially scarce. The objective of this study is to evaluate the effects of DRGs payment on healthcare and health outcomes in China.

Method
A systematic review was conducted. We searched literature databases of PubMed, Cochrane Library, EMBASE, Web of Science, Chinese National Knowledge Infrastructure and SinoMed for empirical studies examining the effects of DRGs payment on healthcare in mainland China. We performed a narrative synthesis of outcomes regarding expenditure, efficiency, quality and equity of healthcare, and assessed the quality of evidence.

Results
Twenty-three publications representing thirteen DRGs payment studies were included, including six controlled before after studies, two interrupted time series studies and five uncontrolled before-after studies. All studies compared DRGs payment to fee-for-service, with or without an overall budget, in settings of tertiary (7), secondary (7) and primary care (1). The involved participants varied from specific groups to all inpatients. DRGs payment mildly reduced the length of stay. Impairment of equity of healthcare was consistently reported, especially for patients exempted from DRGs payment, including: patient selection, cost-shifting and inferior quality of healthcare. However, findings on total expenditure, out of pocket payment (OOP) and quality of healthcare were inconsistent. The quality of the evidence was generally low or very low due to the study design and potential risk of bias of included studies.

Conclusion
DRGs payment may mildly improve the efficiency but impair the equity and quality of healthcare, especially for patients exempted from this payment scheme, and may cause up-coding of medical records. However, DRGs payment may or may not contain the total expenditure or OOP, depending on the components design of the payment. Policymakers should very carefully consider each component of DRGs payment design against policy goals. Well-designed randomised trials or comparative studies are warranted to consolidate the evidence of the effects of DRGs payment on healthcare and health outcomes in LMICs to inform policymaking.
Middle Triassic gastropods from the Besano Formation of Monte San Giorgio, Switzerland
Authors: Pieroni Vittorio , Furrer Heinz 
Published: February 2020

AbstractFor the first time gastropods from the Besano Formation (Anisian/Ladinian boundary) are documented. The material was collected from three different outcrops at Monte San Giorgio (Southern Alps, Ticino, Switzerland). The taxa here described are Worthenia (Humiliworthenia)? aff. microstriata, Frederikella cf. cancellata, ?Trachynerita sp., ?Omphaloptycha sp. 1 and ?Omphaloptycha sp. 2. They represent the best preserved specimens of a larger collection and document the presence in this formation of the clades Vetigastropoda, Neritimorpha and Caenogastropoda that were widespread on the Alpine Triassic carbonate platforms. True benthic molluscs are very rarely documented in the Besano Formation, which is interpreted as intra-platform basin sediments deposited in usually anoxic condition. Small and juvenile gastropods could have been lived as pseudoplankton attached to floating algae or as free-swimming veliger planktotrophic larval stages. Accumulations of larval specimens suggest unfavorable living conditions with prevailing disturbance in the planktic realm or mass mortality events. However, larger gastropods more probably were washed in with sediments disturbed by slumping and turbidite currents along the basin edge or storm activity across the platform of the time equivalent Middle San Salvatore Dolomite.
Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib
Authors: Zhu Guangrong , Shi Jun , Zhang Shaoting , Guo Yue , Huang Ling , Zhao Hui , Jiang Yideng , Sun Jianmin 
Published: February 2020

Abstract
Background
KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation of KIT confers drug resistance of GISTs leading to treatment failure.

Results
In this study, we found that secondary mutation of KIT dramatically increases the ligand-independent activation of the receptor and their resistance to the often used KIT inhibitor Imatinib in the treatment of GISTs. PI3 kinase plays essential roles in the cell transformation mediated by the primary mutation of KIT. We found that loss of PI3 kinase association, but not the inhibition of the lipid kinase activity of PI3 kinase, inhibits the ligand-independent activation of secondary mutations of KIT, and increases their sensitivity to Imatinib, and loss of PI3 kinase association inhibits secondary mutations of KIT mediated cell survival and proliferation in vitro. The in vivo assay further showed that the growth of tumors carrying secondary mutations of KIT is more sensitive to Imatinib when PI3 kinase association is blocked while inhibition of the lipid kinase activity of PI3 kinase cannot inhibit tumor growth, indicating that PI3 kinase is important for the drug resistance of secondary mutation of KIT independent of the lipid kinase activity of PI3 kinase.

Conclusions
Our results suggested that PI3 kinase is necessary for the ligand-independent activation of secondary mutations of KIT, and loss of PI3 kinase association improves the sensitivity of secondary mutations to the targeted therapy independent of the lipid kinase activity of PI3 kinase.
Temporal trends in healthcare resource utilization and costs following acute myocardial infarction
Authors: Shiyovich Arthur , Gilutz Harel , Arbelle Jonathan Eli , Greenberg Dan , Plakht Ygal 
Published: February 2020

Abstract
Background
Acute myocardial infarction (AMI) is associated with greater utilization of healthcare resources and financial expenditure.

Objectives
To evaluate temporal trends in healthcare resource utilization and costs following AMI throughout 2003–2015.

Methods
AMI patients who survived the first year following hospitalization in a tertiary medical center (Soroka University Medical Center) throughout 2002–2012 were included and followed until 2015. Length of the in-hospital stay (LOS), emergency department (ED), primary care, outpatient consulting clinic visits and other ambulatory services, and their costs, were evaluated and compared annually over time.

Results
Overall 8047 patients qualified for the current study; mean age 65.0 (SD = 13.6) years, 30.3% women. During follow-up, LOS and the number of primary care visits has decreased significantly. However, ED and consultant visits as well as ambulatory-services utilization has increased. Total costs have decreased throughout this period. Multivariate analysis, adjusted for potential confounders, showed as significant trend of decrease in LOS and ambulatory-services utilization, yet an increase in ED visits with no change in total costs.

Conclusions
Despite a decline in utilization of most healthcare services throughout the investigated decade, healthcare expenditure has not changed. Further evaluation of the cost-effectiveness of long-term resource allocation following AMI is warranted. Nevertheless, we believe more intense ambulatory follow-up focusing on secondary prevention and early detection, as well as high-quality outpatient chest pain unit are warranted.
Changes in the clinical presentation and outcomes of patients treated for severe malaria in a referral French university intensive care unit from 2004 to 2017
Authors: Lebut Jordane , Mourvillier Bruno , Argy Nicolas , Dupuis Claire , Vinclair Camille , Radjou Aguila , de Montmollin Etienne , Sinnah Fabrice , Patrier Juliette , Le Bihan Clément , Magalahes Eric , Smonig Roland , Kendjo Eric , Thellier Marc , Ruckly Stéphane , Bouadma Lila , Wolff Michel , Sonneville Romain , Houzé Sandrine , Timsit Jean-François 
Published: February 2020

Abstract
Background
In France, the incidence of severe imported malaria cases increased since early 2000. Artesunate was available (temporarily use authorization) since mid-2011 in France and commonly used for severe malaria since early 2013. Thus, the study objectives were to describe the patients with severe imported malaria admitted in intensive care unit (ICU) and assess the changes in clinical presentation and outcomes before and after this date.

Methods
Retrospective observational single-center study in the infectious diseases ICU of a referral university hospital, conducted on patients admitted for severe imported malaria from 2004 to 2017. Demographic variables, severity scores, WHO’s severity criteria on admission, treatment, and ICU and hospital lengths of stay were collected. Patients’ characteristics and outcomes were compared between both periods. A poor outcome was defined as the composite endpoint of death, or requirement for vasopressors, invasive mechanical ventilation and/or renal replacement therapy.

Results
189 patients were included, 98 in 2004–2012 and 91 in 2013–2017, most often from West and Central African countries (96%). The number of WHO criteria for severe malaria was comparable in both groups, but SAPS II, SOFA and ICU length of stay were significantly higher in 2004–2012, while patients of African origin living in France were less frequent (p < 0.01). The outcome was poor for 41/98 cases in 2004–2012 and 12/91 cases in 2013–2017 (p < 0.01). The risk factors of poor outcome on the multivariate logistic regression were a neurological failure (adjusted odds ratio (adjOR = 3.23; 95% CI (1.03–10.08), p = 0.004), cardio-circulatory failure (adjOR = 9.92; 95% CI (2.34–42), p = <0.01) and creatinine blood levels > 265 µmol/L (adjOR = 10.76; 95% CI (3.17–36.53), p < 0.01). In the multivariate analysis, IV artesunate was not associated with a better outcome. Patients of African origin did not seem to have a better outcome than Caucasian patients or those from other origins (adjOR = 0.59; 95% CI (0.21–1.65), p = 0.31).

Conclusion
Patients with imported malaria admitted in ICU in 2013–2017 were less severely ill than those in 2004–2012. These trends could be partially explained by the increasing proportion of African patients visiting friends or relatives or living in endemic areas.
Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review
Authors: Honore Patrick M. , Spapen Herbert D. , Marik Paul , Boer Willem , Oudemans-van Straaten Heleen 
Published: February 2020

AbstractRationale/methodsThe primary aim of the present contribution is to find a literature-based agreement on dose adjustments of vitamin C in critically ill patients undergoing renal replacement therapy (RRT).Available data/study resultsCritical illness is frequently accompanied by severe vitamin C deficiency. High-dose supplementation beneficially affects clinical outcome in small cohorts of patients with sepsis, burn injury, and trauma. There are no specific data on clinical outcomes in patients receiving renal replacement therapy (RRT). Vitamin C plasma concentrations in patients on RRT are comparable to critically ill patients not receiving RRT. Vitamin C is cleared from the circulation during RRT at a rate dependent on the plasma concentration, dose and duration of RRT. Sieving coefficient is about 1. While the dose of RRT is lower than normal renal function, tubular reabsorption is absent. Sparse evidence suggests that vitamin C dosing during continuous RRT should not exceed the dose administered to critically ill patients not receiving continuous RRT. Low plasma concentrations are expected during prolonged RRT because of persistent extracorporeal removal, absent renal reabsorption and enhanced metabolic loss due to circuit-induced oxidative stress. A dosage of twice 1 g vitamin C daily may be necessary to achieve normal plasma concentrations during RRT, but more studies are needed. There is no available evidence that high doses of vitamin C administered over a short period can induce oxalate stones or has pro-oxidant effects.ConclusionsSupplementing vitamin C 1 g twice daily to critically ill patients has a solid pathophysiological rationale and a good safety profile. Patients on RRT probably need similar doses as critically ill patients not receiving RRT. Intravenous vitamin C in a dose of 2 g/day may be necessary to achieve normal plasma concentrations during RRT. However, data on dose adjustment of vitamin C during intermittent or chronic RRT are sparse and require more thorough pharmacokinetic and dose–response studies.
Prescription drug diversion, misuse, and abuse among people living with HIV: a scoping review protocol
Authors: Chibi Buyisile , Torres Neusa Fernanda , Mashamba-Thompson Tivani P. 
Published: February 2020

Abstract
Background
Prescription drugs are controlled medicines due to their potential risks of being diverted, misused, and abused. Since the introduction of antiretroviral (ARVs) drugs, HIV is currently regarded as a chronic condition. However, prescription drug diversion, misuse, and abuse might serve as one of the critical barriers for achieving optimal medication adherence among people living with HIV, thereby negatively impacting the HIV care mandate. The primary aim of this scoping review is to gather evidence on the prevalence, practices, risk factors, and motives associated with prescription drug diversion, misuse, and abuse, as well as the evidence on the association between prescription drug diversion, misuse, and abuse with antiretroviral treatment (ART) adherence.

Methods
This review will be guided by Arksey and O’Malley’s framework as well as recommendations by Levac et al. (Implement Sci 5:69, 2010). We will search the following databases for relevant literature meeting our eligibility criteria: PubMed, Google Scholar, EBSCOhost (Academic Search Complete, MEDLINE, and Newspaper Source), World Health Organization, Science Direct, and Open Access Theses and Dissertations. Studies published within the period of January 1996 to June 2019 are eligible. The included studies should report evidence on the prevalence, practices, risk factors, motives, or association between ART adherence and prescription drug diversion, misuse, and abuse. Thematic analysis will be applied to summarize the review findings.

Discussion
We anticipate finding a considerable number of research studies on prescription drug diversion, misuse, and abuse among people living with HIV. Our synthesis of this evidence base is intended to serve as guidance for future research studies. The study findings will be disseminated through the traditional academic platforms, such as peer-reviewed publications and presentations at relevant local and international conferences, symposiums, and seminars.

Systematic review registration
PROSPERO CRD42017074076
Net absorption and liver metabolism of amino acids and heat production of portal-drained viscera and liver in multiparous sows during transition and lactation
Authors: Hu Liang , Kristensen Niels Bastian , Che Lianqiang , Wu De , Theil Peter Kappel 
Published: February 2020

Abstract
Background
Determination of nutrient requirements in the late gestating and lactating sows is essential to optimize sow productivity. The objectives of the present study were to quantify amino acid (AA) fluxes and heat production across portal-drained viscera (PDV) and liver in multiparous sows during transition and lactation.

Methods
Eight second parity sows were fitted with indwelling catheters in the femoral artery and in the mesenteric, portal and hepatic veins. Eight hourly sets of blood samples were taken starting 0.5 h before feeding at − 10, − 3, + 3, and + 17 d in milk (DIM). Blood gases, plasma metabolites and apparent total tract digestibility (ATTD) of nutrients were measured.

Results
Feed intake, the ATTD of DM, energy, nitrogen, fat and crude fiber changed with DIM (P < 0.001). Except for Glu, O2, and urea, all net portal fluxes were positive, and all were affected by DIM (P < 0.05) and by sampling time (P < 0.01). Compared with pre partum levels, net portal uptake of AA was 3-63% lower at + 3 DIM but 40-100% higher at + 17 DIM. Net portal fluxes of AA peaked at 1.5 to 2.5 h after feeding except for Glu, and they were positively correlated with changes in sow feed intake across DIM. The net portal recovery was low for Met (49%), Thr (54%), and His (54%) and high for the remaining essential AA (63-69%) and none of them differed across DIM. Net hepatic uptake (i.e. hepatic oxidation) of Lys, Thr, Ile, Leu and Phe peaked at 0.5 to 2.5 h after feeding, whereas uptake of Trp, Val, and His was constant, while that of Met was close to zero.

Conclusion
The net portal recovery was substantially lower for Met, Thr, and His than the remaining essential AA. Hepatic AA oxidation peaks 0.5 to 2.5 h after feeding. The heat production in PDV and liver was approximately two-fold higher at peak lactation compared to other stages. The study suggests that lysine was the limiting AA in peak lactation but not in early lactation.