bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of salvianolate injection in treating acute myocardial infarction: a meta-analysis and systematic literature review
Authors: Chen Pengfei , Zhang He , Gao Zhuye , Shi Dazhuo , Zhang Jie 
Published: December 2024

PurposeSalvianolate for injection (SFI) is a widely used treatment for acute myocardial infarction (AMI). This study aims to assess the efficacy and safety of SFI in treating AMI by synthesizing evidence from published randomized controlled trials (RCTs).MethodsSeven databases were searched for relevant RCTs published up to 1 July 2024. Two investigators independently conducted the literature searches, data extraction, and quality assessment. Subgroup and sensitivity analyses were performed to address potential heterogeneity. Data analyses were conducted using RevMan 5.4 software.ResultThirty RCTs with a total of 3,931 participants were included in the study and analyzed. The results revealed that SFI significantly reduced major adverse cardiac events (MACEs) (RR = 0.34, 95% CI: 0.24 to 0.49, p &lt; 0.05). In addition, SFI lowered creatine kinase-MB (CK-MB) (MD = −5.65, 95% CI: −9.55 to −1.76, p &lt; 0.05) and improved left ventricular ejection fraction (LVEF) (MD = 6.2, 95% CI: 4.82 to 7.57, p &lt; 0.05). Further reductions were observed in C-reactive protein (CRP) (MD = −6.17, 95% CI: −8.11 to −4.23, p &lt; 0.05), malondialdehyde (MDA) (MD = −1.95, 95% CI: −2.08 to −1.83, p &lt; 0.05), and endothelin-1 (ET-1) (MD = −12.27, 95% CI: −17.13 to −7.40, p &lt; 0.05). The incidence of adverse events did not significantly differ between the EG and CG [RR = 0.74, 95% CI: 0.42 to 1.33, p = 0.32].ConclusionThis study suggests that SFI may be a promising alternative therapy for treating AMI without increasing the risk of adverse events. However, our findings may be limited by the quality of the existing studies. High-quality RCTs are needed to provide more robust evidence.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024567279.
University teachers’ beliefs about the use of generative artificial intelligence for teaching and learning
Authors: Cabellos Beatriz , de Aldama Carlos , Pozo Juan-Ignacio 
Published: December 2024

IntroductionThe growing presence of generative artificial intelligence (GenAI) in our society, particularly in the educational field, is undeniable. This fact has led to various studies on its implications for learning and teaching. However, as with other technological resources, these implications will depend on how teachers use GenAI. Therefore, it is essential to identify teachers’ beliefs regarding the use of GenAI for teaching and learning.MethodsTo this end, a questionnaire was designed and completed by 321 university teachers. This questionnaire consisted of two parts. The first included questions about the participants’ demographic information and a Likert scale on teachers’ pedagogical beliefs. The second part consisted of a 32-item Likert scale that evaluated teachers’ beliefs about the impact of GenAI on their students’ learning and their own teaching. These aspects were reflected through items that considered GenAI as either an educational opportunity or a threat.ResultsThe results showed that, of all the variables analyzed, only pedagogical beliefs and the frequency of previous GenAI use influenced beliefs about GenAI usage. Specifically, teachers with constructivist beliefs saw greater potential in GenAI compared to others. Similarly, teachers who regularly used these technologies had more positive beliefs about their educational use than those who used them sporadically or not at all. Lastly, it was also observed that while teachers valued the positive effects of GenAI on their teaching work, they also considered that its use could be detrimental to the learning processes of their students, making them more superficial.DiscussionThese findings underline the importance of providing teachers with training focused on constructive approaches that enable them to maximize the potential of GenAI in education. In particular, it is crucial to promote teaching practices that, through student-centered GenAI use, foster active and reflective processes in students, aligned with the competencies demanded by today’s society.
Association of age at menopause and suicide risk in postmenopausal women: a nationwide cohort study
Authors: Moon Daa Un , Kim Hyewon , Jung Jin-Hyung , Han Kyungdo , Jeon Hong Jin 
Published: December 2024

IntroductionEarly age at menopause has been linked to various adverse health outcomes, but its association with suicide risk remains underexplored. This study aims to assess the relationship between age at menopause and suicide risk among postmenopausal women.MethodsThis retrospective cohort study analyzed data from the Korean National Health Insurance System (NHIS), covering 1,315,795 postmenopausal women aged 30 years and above, from 2009 to 2021. Menopausal age was classified as primary ovarian insufficiency (under 40 years), early menopause (40-44 years), average menopause (45-49 and 50-54 years), and late menopause (55 years and older). Suicide incidence was identified using ICD-10 codes for primary cause of death. Multivariable Cox proportional hazards models were utilized to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsAcross the 12-year follow-up, there were 2,986 suicides. Women with primary ovarian insufficiency exhibited the highest suicide risk (HR, 1.43; 95% CI, 1.14–1.78, p &lt; 0.001), followed by those with early menopause (HR, 1.31; 95% CI, 1.15–1.50, p &lt; 0.001), and those with menopause between 45 and 49 (HR, 1.13; 95% CI, 1.04–1.23, p &lt; 0.001) compared to the reference group undergoing menopause at age of 50-54.DiscussionEarly onset of menopause, particularly primary ovarian insufficiency, is associated with a significantly elevated risk of suicide. These findings underscore the need for targeted interventions and support for women experiencing early menopause. This study highlights the importance of monitoring mental health in postmenopausal women and suggests further research to explore the underlying mechanisms linking early menopause to increased suicide risk.
Smoking-attributable peptic ulcer disease mortality worldwide: trends from 1990 to 2021 and projections to 2046 based on the global burden of disease study
Authors: Li Hao , Shi Qi , Chen Caiyun , Li Ju , Wang Kai 
Published: December 2024

ObjectiveSmoking is a major risk factor for peptic ulcer disease (PUD) mortality. This study aims to analyze global trends in smoking-attributable PUD mortality from 1990 to 2021 and project future trends to 2046.MethodsData were obtained from the Global Burden of Disease Study 2021. We calculated age-standardized mortality rates (ASMR) and estimated annual percentage changes (EAPC) for smoking-attributable PUD mortality. Bayesian Age-Period-Cohort models were used to project future trends.ResultsFrom 1990 to 2021, global smoking-attributable PUD deaths decreased from 48,900 to 29,400, with the ASMR declining from 1.2 to 0.3 per 100,000 (EAPC: −4.25%). High-income regions showed faster declines, while some low- and middle-income countries experienced slower progress or even increases. Projections suggest a continued global decline in smoking-attributable PUD mortality to 2046, with persistent regional disparities. By 2046, the global ASMR is expected to decrease to approximately 0.1 per 100,000, with higher rates persisting in certain regions such as the Solomon Islands (3.7 per 100,000) and Cambodia (1.6 per 100,000).ConclusionWhile global smoking-attributable PUD mortality has significantly decreased and is projected to continue declining, substantial regional disparities persist. These findings underscore the need for targeted tobacco control interventions, particularly in high-risk regions, to further reduce the global burden of smoking-attributable PUD mortality.
A study on cognitive trajectory changes and predictive factors in middle-aged and older adults individuals with dual sensory impairment based on the health social determinants model
Authors: Ma Li , Pang Jiaxue , Liu Qiankun , Li Pengyao , Huang Juju , Xu Yang , Xie Hui 
Published: December 2024

AimThis study aims to explore the cognitive trajectory changes in middle-aged and older adults individuals with dual sensory impairment (simultaneous visual and hearing impairment) and to identify the predictors of different trajectory changes.MethodsBased on the longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) from 2013 to 2020, data from 2,369 middle-aged and older adults individuals with dual sensory impairment were selected. A latent variable growth mixture model was constructed to analyze the cognitive function development trajectories in this population and to identify their predictive factors.ResultsThe cognitive function development trajectories in the middle-aged and older adults population can be categorized into three types: high cognitive level stable group, low cognitive level slowly declining group, and moderate cognitive level rapidly declining group. Logistic regression analysis showed that age (OR 30.544; 95% CI 9.35–99.754; p &lt; 0.001), sleep duration (OR 0.559; 95% CI 0.343–0.909; p &lt; 0.005), education (OR 0.009; 95% CI 0.003–0.025; p &lt; 0.001), marital status (OR 2.122; 95% CI 1.457–3.090; p &lt; 0.001), social participation (OR 0.499; 95% CI 0.379–0.658; p &lt; 0.001), place of residence (OR 1.471; 95% CI 1.089–1.988; p &lt; 0.001), and medical insurance (OR 0.353; 95% CI 0.169–0.736; p &lt; 0.005) are predictive factors for cognitive function trajectories in this population.ConclusionThere is group heterogeneity in the cognitive function development trajectories among middle-aged and older adults individuals with dual sensory impairment. Factors such as less than 4 h of nighttime sleep, low social participation, alcohol consumption, and lack of medical insurance are modifiable risk factors for cognitive decline in this population. Preventive strategies should be formulated accordingly, especially for vulnerable groups, including older rural residents and those with lower educational attainment, to prevent cognitive function deterioration in middle-aged and older adults individuals with dual sensory impairment.
Climate change impacts on the Chiffa basin (northern Algeria) using bias-corrected RCM data
Authors: Madani Amina Zoubida , Hermassi Taoufik , Taibi Sabrina , Dakhlaoui Hamouda , Mechergui Mohamed 
Published: December 2024

IntroductionThis study aims to assess the efficacy of Quantile mapping (QM) and Delta change (DC) bias correction methods to improve hydrological simulations of the Chiffa basin in northern Algeria. The main issue addressed is the need for corrected climate data to provide reliable hydrological projections in semi-arid climates.MethodsHydrological simulations were conducted using the GR2M conceptual rainfall-runoff model, recognized for its robustness in Mediterranean climates. This model was coupled with precipitation simulations from the Rossby Centre regional atmospheric model RCA4 of the Coordinated Regional Climate Downscaling Experiment (Cordex-Africa) forced by two global circulation models (MPI-ESM-LR and CRNM-CM5). Hydrological projections were produced for the future period 20702099 under RCP 4.5 and RCP 8.5 scenarios, comparing raw and bias-corrected data.Results and discussionThe findings indicate that raw precipitation data are inadequate for reflecting future rainfall trends and simulating future flows. Bias correction methods significantly improved the models performance, with the coefficient of determination (R2) increasing from 0.440.53 to 0.830.97. Additionally, regional climate models project a 5 to 8% decrease in annual flows by the end of the 21st century under RCP 4.5 and RCP 8.5 scenarios. These results highlight the importance of bias correction methods for hydrological impact studies, and we recommend implementing specific adaptation measures, such as improved irrigation efficiency, development of water storage infrastructure, and adoption of drought-resistant agricultural practices. Future research should focus on employing multivariate bias correction methods, utilizing higher-resolution climate data (≤10 km), and implementing ensemble modeling approaches to better characterize uncertainties.
The snow must go on: how German cross-country skiers maintained training and performance in the face of COVID-19 lockdowns
Authors: Kock H. , Schürer A. , Staunton C. A. , Hanstock Helen G. 
Published: December 2024

BackgroundThe Covid-19 pandemic in 2020 led to disruption of sporting events, with athletes obliged to comply with national lockdown restrictions.PurposeTo investigate the effect of the Covid-19 pandemic restrictions on national-team XC skiers' annual and weekly training distribution from training diaries, results from submaximal and maximal physiological roller ski tests, and competition results from the International Ski and Snowboard Federation (FIS) world cup.MethodsAnnual and weekly training type (specific, non-specific, strength, other) and intensity distribution (TID) data were collected for 12 German XC-skiers (Tier 4/5; BM: 67 ± 7 kg; age 26 ± 3 years; 6♀: V̇O2max 61.3 ± 3.4 ml · kg · min−1; 6♂: V̇O2max 72.5 ± 6.2 ml · kg · min−1). TID was categorized using a 5-zone scale with Zones 1–2 representative of intensities below the first lactate threshold (LT1), zone 3 between LT1 and LT2, and zones 4–5 above LT2. Training data were grouped by lockdown periods in season 20/21 (L1/L2) and compared to data from the corresponding weeks in 19/20 (C1/C2). Laboratory testing was performed in the general preparation period prior to competition for both seasons. Differences between seasons (C1/C2 vs. L1/L2) in training and performance variables were analysed using repeated-measures ANOVA and linear mixed models.ResultsTotal annual training duration increased by 9% during 20/21 (928 ± 79 h · year−1) compared to 19/20 (852 ± 73 h · year−1). During L1, skiers achieved a greater weekly training duration (mean differences (Δx¯: 7.7 h · week−1) compared to C1, due to an increase in non-specific training (Δx¯: 7.0 h · week−1), whereas L2 resulted in greater weekly training compared with C2 due to a higher specific endurance training volume (Δx¯: 1.4 h · week−1). In 20/21 skiers performed a higher volume of Zone 1 (Δx¯: 149 h · year−1). Laboratory test- and FIS racing performance improved from 19/20 to 20/21.ConclusionGerman XC skiers' training characteristics, laboratory- and racing performance were significantly different between the two seasons. In fact, training duration as well as laboratory- and racing performance increased from 19/20 to 20/21. In spite of seasonal variation in performance and training within an Olympic cycle these findings might suggest that skiers adapted their training effectively to pandemic constraints, ultimately enhancing performance outcomes.
Momoridica charantia and fermented Momoridica charantia with Leuconostoc mesenteroides MKSR change intestinal microbial diversity indices and compositions in high-fat and high-cholesterol diet-fed C57BL/6 male mice
Authors: Moon Heewon , Lee Kangwook , Ha Jung-Heun , Kim Na Yeun , Shin Hyo Ri , Cho Tae Jin , Oh Nam Su , Park Jinbong , Tang Jingsi , Kim Jae Kyeom , Kim Misook 
Published: December 2024

IntroductionThis study explores the impact of 4% Momordica charantia (MC) and 4% fermented Momordica charantia (FMC) on gut microbiota and obesity-related health outcomes in male C57BL/6 mice, a model relevant to veterinary sciences for understanding metabolic and gut health disorders in animals.MethodsMice were assigned to four dietary regimens, including control, high-fat and high-cholesterol diet (POS), POS with 4% MC, and POS with 4% FMC (fermented with Leuconostoc mesenteroides MKSR) over 12 weeks. Fecal samples were collected for 16S rRNA sequencing to evaluate microbial diversity and composition, key factors influencing animal health.ResultsBoth MC and FMC groups exhibited significant alterations in gut microbial communities, with FMC inducing a distinct shift in beta diversity indices. Changes in microbial taxa such as Bacteroidetes, Verrucomicrobia, and Firmicutes were observed, along with enhancement in the ‘L-glutamate and L-glutamine biosynthesis’ pathway. These shifts were associated with reduced body weight gain and liver weights.DiscussionThe findings suggest that MC and FMC have potential benefits for managing diet-induced metabolic disorders and protecting against obesity by modulating gut microbiota and improving gut metabolism.
Construction and immunological evaluation of recombinant adenovirus vaccines of new novel NADC34-PRRSV strains in pigs
Authors: Xie Chang-zhan , Zhang Ping , Wang Zheng , Tao Yi-mo , Cui Zhuo-dong , Nan Fu-long , Zhang Fu-chao , Ren Yun-xin , Zhang He , Lu Hui-jun 
Published: December 2024

IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive and respiratory diseases in sow herds and piglets. The emergence of ORF5 RFLP 1–7-4-like (NADC34-like) PRRSV strain in China has brought a new round of challenges to PRRSV prevention.MethodsIn addition, recombinant adenovirus vaccine candidates against the newly emerged NADC34-like strain were constructed in the study; the immunogenicity of the vaccine was investigated in piglets. After inoculation with PRRSV recombinant adenovirus, specific antibodies, neutralizing antibodies, and levels of IFN-γ and IL-4 cytokines were detected in serum.ResultsThirty-five days after immunization, the levels of IFN-γ and IL-4 cytokines in the pac-Ad5-34-GP3, pac-Ad5-34-GP5, and pac-Ad5-34-GP35 experimental groups were significantly higher (p &lt; 0.05) than those of the PBS and the adenovirus group. All vaccines can cause corresponding Th1 and Th2 immune responses based on animal experimental results. After the challenge, no obvious clinical symptoms were observed in the immune groups compared with the control group, vaccinated animals could reduce the occurrence of viremia, and the occurrence of viremia was alleviated, with no obvious pathological changes in the lungs, indicating that recombinant adenovirus vaccine could provide a good protective immunity and produce a good humoral and cellular immune response at the same time.DiscussionIt shows that the recombinant adenovirus vaccine group has better protection against the virus. Provide vaccine reserve and theoretical support for the emergence of new PRRSV subtypes in China.
Relação entre mutação MTHFR e transtorno depressivo maior: implicações genéticas e clínicas
Authors: Corgosinho Elisa Silva , Carvalho Isabela Storch , Carvalho Júlia Storch , Carvalho José Luiz Fernandes de 
Published: December 2024

A MTHFR é uma enzima fundamental no metabolismo de um carbono, a qual abrange os metabolismos da homocisteína (Hcy) e do folato. O Transtorno Depressivo Maior (TDM) é um transtorno mental prevalente, caracterizado por altas taxas de morbidade, recorrência e risco de suicídio. A etiopatogenia envolve fatores ambientais e fatores genéticos, sendo um deles polimorfismos do gene responsável pela enzima MTHFR.
Phytochemical components and antimicrobial properties of Thymus pallescens de Noé essential oil against nosocomial uropathogens
Authors: Kheira Setti Ahmed , Hakim Tefiel , Amine Chouhim Kada Mohamed , Mustapha Bouhanna , Mohamed Chahbar , Farid Chebrouk , Aboumustapha Mohamed , Benhafsa Fouad Mekhalef , Omar Kharoubi 
Published: December 2024

Urinary infection is a real public health problem with 15.0% of all antibiotics prescription. The aim of the present study was to investigate the in vitro antimicrobial properties of essential oil of thyme (Thymus pallescens de Noé) obtained by hydrodistillation against uropathogens isolated from urine samples of patients placed in the Hospital of Thniet El had. Chromatographic analysis showed that the major compounds of T. pallescens de Noé oil were respectively carvacrol (69.85%) and ɣ-terpinene (11.44%). The essential oil of Thymus pallescens de Noé revealed significant antimicrobial activity. The highest antimicrobial activity appeared to be against Candida albicans with a mean zone of inhibition diameter of 46.33±0.57mm. Thyme had the highestt zones of inhibition against Gram-positive bacteria S saprophyticus and Micrococcus sp than Gram-negative bacteria: Klebsella pneumonia, Escherichia coli and Enterobacter aerogens with a mean halo of inhibition diameter of 27.33±1.15, 42.66±2.08, 21.33±0.57, 21.66±2.08 and 18.66±0.57 mm respectively. In conclusion, Thymus pallescens de Noé possesses a great potential as antiseptic related to its major component carvacole and can be used for the the treatment of UTI.
Functionalized Periosteum-Derived Microsphere-Hydrogel with Sequential Release of E7 Short Peptide/miR217 for Large Bone Defect Repairing
Authors: Yao Jun , Zu Dan , Dong Qi , Xia Jiajie , Wang Xiaonan , Guo Jingjing , Ma Gaoxiang , Wu Bing , Fang Bin 
Published: December 2024

Large bone defects are still a persistent challenge in orthopedics. The availability limitations and associated complications of autologous and allogeneic bone have prompted an increasing reliance on tissue engineering and regenerative medicine. In this study, we developed an injectable scaffold combining an acellular extracellular periosteal matrix hydrogel with poly(
d
,
l
-lactate-
co
-glycol-acetate) microspheres loaded with the E7 peptide and miR217 (miR217/E7@MP-GEL). Characterization of the composites included morphological analysis by scanning electron microscopy, degradation and swelling tests, in vitro and in vivo biological evaluation, and the biological activity evaluation of mesenchymal stem cells (MSCs) through their effects on cell recruitment, proliferation, and osteogenic differentiation. The designed hydrogels demonstrated good physical and chemical properties that are cytocompatible and suitable for cell recruitment. In vitro studies confirmed the high biological activity of the release agent, which markedly enhanced the proliferation and osteogenic differentiation of MSCs. In vivo application to a rat model of a femur defect exhibited a significant increase in bone volume and density over 7 weeks, resulting in enhanced bone regeneration. Acellular periosteum-based hydrogels combined with the E7 peptide and miR217-loaded poly(
d
,
l
-lactate-
co
-glycol-acetate) microspheres can promote effective bone regeneration through the recruitment, proliferation, and osteogenic differentiation of MSCs, which provides a promising approach for the treatment of large bone defects.
О моделях поддержки принятия решений в оборонно-промышленном комплексе
Authors: Ерешко Ф.И. , Шевченко В.В. 
Published: December 2024

В работе рассматриваются вопросы поддержки принятия решений в оборонно-промышленном комплексе России (ОПК). Анализируются структура комплекса, система контрагентов, с которыми его организации взаимодействуют в процессе своей производственно-экономической деятельности. Классифицируются решения, принимаемые в процессе управления оборонными организациями различного уровня. Обозначается модельно-алгоритмический инструментарий поддержки принятия решений в оборонно-промышленном комплексе. Предлагается целостная и взаимоувязанная система моделей поддержки принятия решений в процессе управления комплексом, рассматриваются процедуры использования этой системы моделей.
The paper deals with the issues of decision support in the Russian military-industrial complex (MIC). The structure of the complex, the system of counterparties with which its organizations interact in the course of their production and economic activities are analyzed. The decisions made in the process of managing defense organizations of various levels are classified. The model-algorithmic tools of decision support in the military-industrial complex are designated. A holistic and interconnected system of decision support models in the process of complex management is proposed, and procedures for using this system of models are considered.