bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncertainty-quantified parametrically homogenized constitutive models (UQ-PHCMs) for dual-phase α/β titanium alloys
Authors: Kotha Shravan , Ozturk Deniz , Ghosh Somnath 
Published: August 2020

AbstractThis paper develops an uncertainty-quantified parametrically homogenized constitutive model (UQ-PHCM) for dual-phase α/β titanium alloys such as Ti6242S. Their microstructures are characterized by primary α-grains consisting of hcp crystals and transformed β-grains consisting of alternating laths of α (hcp) and β (bcc) phases. The PHCMs bridge length-scales through explicit microstructural representation in structure-scale constitutive models. The forms of equations are chosen to reflect fundamental deformation characteristics such as anisotropy, length-scale dependent flow stresses, tension-compression asymmetry, strain-rate dependency, and cyclic hardening under reversed loading conditions. Constitutive coefficients are functions of representative aggregated microstructural parameters or RAMPs that represent distributions of crystallographic orientation and morphology. The functional forms are determined by machine learning tools operating on a data-set generated by crystal plasticity FE analysis. For the dual phase alloys, an equivalent PHCM is developed from a weighted averaging rule to obtain the equivalent material response from individual PHCM responses of primary α and transformed β phases. The PHCMs are readily incorporated in FE codes like ABAQUS through user-defined material modeling windows such as UMAT. Significantly reduced number of solution variables in the PHCM simulations compared to micromechanical models, make them several orders of magnitude more efficient, but with comparable accuracy. Bayesian inference along with a Taylor-expansion based uncertainty propagation method is employed to quantify and propagate different uncertainties in PHCM such as model reduction error, data sparsity error and microstructural uncertainty. Numerical examples demonstrate the accuracy of PHCM and the relative importance of different sources of uncertainty.
Printable 3D vocal tract shapes from MRI data and their acoustic and aerodynamic properties
Authors: Birkholz Peter , Kürbis Steffen , Stone Simon , Häsner Patrick , Blandin Rémi , Fleischer Mario 
Published: August 2020

AbstractA detailed understanding of how the acoustic patterns of speech sounds are generated by the complex 3D shapes of the vocal tract is a major goal in speech research. The Dresden Vocal Tract Dataset (DVTD) presented here contains geometric and (aero)acoustic data of the vocal tract of 22 German speech sounds (16 vowels, 5 fricatives, 1 lateral), each from one male and one female speaker. The data include the 3D Magnetic Resonance Imaging data of the vocal tracts, the corresponding 3D-printable and finite-element models, and their simulated and measured acoustic and aerodynamic properties. The dataset was evaluated in terms of the plausibility and the similarity of the resonance frequencies determined by the acoustic simulations and measurements, and in terms of the human identification rate of the vowels and fricatives synthesized by the artificially excited 3D-printed vocal tract models. According to both the acoustic and perceptual metrics, most models are accurate representations of the intended speech sounds and can be readily used for research and education.
Impaired consciousness at stroke onset in large hemisphere infarction: incidence, risk factors and outcome
Authors: Li Jie , Zhang Ping , Wu Simiao , Yuan Ruozhen , Liu Junfeng , Tao Wendan , Wang Deren , Liu Ming 
Published: August 2020

AbstractImpaired consciousness (IC) at stroke onset in large hemispheric infarctions (LHI) patients is common in clinical practice. However, little is known about the incidence and risk factors of IC at stroke onset in LHI. Besides, stroke-related complications and clinical outcomes in relation to the development of IC has not been systematically examined. Data of 256 consecutive patients with LHI were collected. IC at stroke onset was retrospectively collected from the initial emergency department and/or admission records. Of the 256 LHI patients enrolled, 93 (36.3%) had IC at stroke onset. LHI patients with IC at stroke onset were older (median age 66 vs. 61, p = 0.041), had shorter prehospital delay (24 vs. 26 h, p < 0.001and higher baseline National Institutes of Health Stroke Scale (NIHSS) score (19 vs. 12, p < 0.001). Independent risk factors of IC at stroke onset were high NIHSS score (odds ratio, OR 1.17, 95% confidence interval [CI] 1.12 to 1.23) and atrial fibrillation (OR 1.93, 95% CI 1.07 to 3.47). Dyslipidemia appeared to protect against IC at stroke onset (adjusted OR 0.416, 95% CI 0.175 to 0.988). IC at stroke onset was associated with higher frequency of stroke-related complications (90.32% vs. 67.48%, p < 0.001), especially brain edema (45.16% vs. 23.31%, p < 0.001) and pneumonia (63.44% vs. 47.82%, p = 0.019). The IC group had higher rates of in-hospital death (23.66% vs. 11.66%, p = 0.012), 3-month mortality (49.46% vs. 24.87%, p = 0.002), and 3-month unfavorable outcome (64.51% vs. 49.07%, p = 0.017). However, after adjusting for age, baseline NIHSS score and other confounders, IC at stroke onset was not an independent predictor of in-hospital death (adjusted OR 0.56, 95% CI 0.22 to 1.47), 3-month mortality (adjusted OR 0.54, 95% CI 0.25 to 1.14) and 3-month unfavorable outcome (adjusted OR 0.64, 95% CI 0.31 to 1.33) in LHI patients (all p > 0.05). Our results suggested that IC occur in 1 out of every 3 LHI patients at stroke onset and was associated with initial stroke severity and atrial fibrillation. LHI patients with IC at stroke onset more frequently had stroke-related complications, 3-month mortality and unfavorable outcome, whereas IC was not an independent predictor of poor outcomes.
The rare sugar d-tagatose protects plants from downy mildews and is a safe fungicidal agrochemical
Authors: Mochizuki Susumu , Fukumoto Takeshi , Ohara Toshiaki , Ohtani Kouhei , Yoshihara Akihide , Shigematsu Yoshio , Tanaka Keiji , Ebihara Koichi , Tajima Shigeyuki , Gomi Kenji , Ichimura Kazuya , Izumori Ken , Akimitsu Kazuya 
Published: August 2020

AbstractThe rare sugar d-tagatose is a safe natural product used as a commercial food ingredient. Here, we show that d-tagatose controls a wide range of plant diseases and focus on downy mildews to analyze its mode of action. It likely acts directly on the pathogen, rather than as a plant defense activator. Synthesis of mannan and related products of d-mannose metabolism are essential for development of fungi and oomycetes; d-tagatose inhibits the first step of mannose metabolism, the phosphorylation of d-fructose to d-fructose 6-phosphate by fructokinase, and also produces d-tagatose 6-phosphate. d-Tagatose 6-phosphate sequentially inhibits phosphomannose isomerase, causing a reduction in d-glucose 6-phosphate and d-fructose 6-phosphate, common substrates for glycolysis, and in d-mannose 6-phosphate, needed to synthesize mannan and related products. These chain-inhibitory effects on metabolic steps are significant enough to block initial infection and structural development needed for reproduction such as conidiophore and conidiospore formation of downy mildew.
Laser cooling of ytterbium-doped silica glass
Authors: Mobini Esmaeil , Rostami Saeid , Peysokhan Mostafa , Albrecht Alexander , Kuhn Stefan , Hein Sigrun , Hupel Christian , Nold Johannes , Haarlammert Nicoletta , Schreiber Thomas , Eberhardt Ramona , Tünnermann Andreas , Sheik-Bahae Mansoor , Mafi Arash 
Published: August 2020

AbstractLaser cooling of a solid is achieved when a coherent laser illuminates the material in the red tail of its absorption spectrum, and the heat is carried out by anti-Stokes fluorescence of the blue-shifted photons. Solid-state laser cooling has been successfully demonstrated in several materials, including rare-earth-doped crystals and glasses. Here we show the net cooling of high-purity Yb-doped silica glass samples that are fabricated with low impurities to reduce their parasitic background loss for fiber laser applications. The non-radiative decay rate of the excited state in Yb ions is very small in these glasses due to the low level of impurities, resulting in near-unity quantum efficiency. We report the measurement of the cooling efficiency as a function of the laser wavelength, from which the quantum efficiency of the Yb-doped silica is calculated.
Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease
Authors: Lloyd-Evans Emyr , Waller-Evans Helen 
Published: August 2020

Abstract
Neurosteroids are steroid hormones synthesised de novo in the brain and peripheral nervous tissues. In contrast to adrenal steroid hormones that act on intracellular nuclear receptors, neurosteroids directly modulate plasma membrane ion channels and regulate intracellular signalling. This review provides an overview of the work that led to the discovery of neurosteroids, our current understanding of their intracellular biosynthetic machinery, and their roles in regulating the development and function of nervous tissue. Neurosteroids mediate signalling in the brain via multiple mechanisms. Here, we describe in detail their effects on GABA (inhibitory) and NMDA (excitatory) receptors, two signalling pathways of opposing function. Furthermore, emerging evidence points to altered neurosteroid function and signalling in neurological disease. This review focuses on neurodegenerative diseases associated with altered neurosteroid metabolism, mainly Niemann-Pick type C, multiple sclerosis and Alzheimer disease. Finally, we summarise the use of natural and synthetic neurosteroids as current and emerging therapeutics alongside their potential use as disease biomarkers.
Early warning signals indicate a critical transition in Betelgeuse
Authors: George Sandip V. , Kachhara Sneha , Misra Ranjeev , Ambika Gouri 
Published: August 2020

Context.Critical transitions occur in complex dynamical systems when the system dynamics undergoes a regime shift. These can often occur with little change in the mean amplitude of the system response prior to the actual time of transition. The recent dimming and brightening event in Betelgeuse occurred as a sudden shift in the brightness and has been the subject of much debate. Internal changes or an external dust cloud have been suggested as reasons for this change in variability.Aims.We examine whether the dimming and brightening event of 2019–20 could be due to a critical transition in the pulsation dynamics of Betelgeuse by studying the characteristics of the light curve prior to transition.Methods.We calculated the quantifiers hypothesized to rise prior to a critical transition for the light curve of Betelgeuse up to the dimming event of 2019–20. These included the autocorrelation at lag-1, variance, and the spectral coefficient calculated from detrended fluctuation analysis, in addition to two measures that quantify the recurrence properties of the light curve. Significant rises are confirmed using the Mann-Kendall trend test.Results.We see a significant increase in all quantifiers (p <  0.05) prior to the dimming event of 2019–20. This suggests that the event was a critical transition related to the underlying nonlinear dynamics of the star.Conclusions.Together with results that suggest a minimal change inTeffand IR flux, a critical transition in the pulsation dynamics might be a reason for the unprecedented dimming of Betelgeuse. The rise in the quantifiers we studied prior to the dimming event supports this possibility.
Implementation of a biopsy protocol to improve detection of esophageal eosinophilia: a Danish registry-based study
Authors: Krarup Anne Lund , Drewes Asbjørn Mohr , Ejstrud Per , Laurberg Peter Thaysen , Vyberg Mogens 
Published: August 2020

Abstract
Background In the North Denmark Region (580 272 inhabitants), only 0–4 cases of possible eosinophilic esophagitis (EoE) were identified annually in 1999–2010, suggesting underdiagnosis. This study aimed to increase the diagnosis of EoE by introducing a regional biopsy protocol for patients with dysphagia.
Methods In 2011, leaders of regional endoscopy units attended a consensus meeting where a biopsy protocol was proposed. The national pathology registry was used to identify patients with esophageal eosinophilic inflammation during 2007–2017.
Results Discussion resulted in consensus on a protocol to take eight biopsy samples in dysphagia patients (four biopsies from 4 cm and 14 cm above the esophagogastric junction–“4–14–4 rule”) regardless of the macroscopic appearance, and to code eosinophilia systematically in the pathology registry. A pictogram showing the 4–14–4 rule was sent to all endoscopy units. The number of patients with esophageal eosinophilia detected per year increased 50-fold after the protocol was implemented in 2011 (median of 1 [interquartile range 0–3] vs. 52 [47–56]; P < 0.001), and the number of biopsy samples per patient doubled (median 4 [4–5] vs. 8 [6–9]; P < 0.04). Of 309 patients diagnosed with esophageal eosinophilia in 2007–2017, 24 % had erosive esophagitis or Barrett’s esophagus, and 74 % had EoE.
Conclusions A consensus-based biopsy protocol and improved coding of eosinophilia in the pathology registry resulted in a 50-fold increase in patients diagnosed with esophageal eosinophilia/year. These patients can now receive treatment. The effort to establish the protocol and change the culture of endoscopists and pathologists was minimal.
The Role of Advanced Endoscopic Resection of Diverse Skull Base Malignancies: Technological Analysis during an 8-Year Single Institutional Experience
Authors: Rutland John W. , Goldrich David , Loewenstern Joshua , Banihashemi Amir , Shuman William , Sharma Sonam , Balchandani Priti , Bederson Joshua B. , Iloreta Alfred M. , Shrivastava Raj K. 
Published: August 2020

Abstract
Background Resection of skull base malignancies poses complex pathological and treatment-related morbidities. Recent technological advancements of endoscopic endonasal surgery (EES) offer the ability to reexamine traditional treatment paradigms with endoscopic procedures. The utility of EES was quantitatively examined in a longitudinal series with attention to morbidities and postoperative outcomes.
Methods A single-center retrospective review was performed of all malignant sinonasal tumors from 2010 to 2018. Patients with purely EES were selected for analysis. Disease features, resection extent, complications, adjuvant treatment, recurrence, and survivability were assessed. Despite the mixed pathological cohort, analysis was performed to identify technical aspects of resection.
Results A total of 68 patients (47.6% males and 52.4% females, average age: 60.3 years) were included. A diversity of histotypes included clival chordoma (22.1%), olfactory neuroblastoma (14.7%), squamous cell carcinoma (11.8%), and adenoid cystic carcinoma (11.8%). Gross total resection (GTR) was achieved in 83.8% of cases. Infection (4.4%) and cerebrospinal fluid leak (1.5%) were the most common postoperative complications. Total 46 patients (67.6%) underwent adjuvant treatment. The average time between surgery and initiation of adjunctive surgery was 55.7 days.
Conclusion In our 8-year experience, we found that entirely endoscopic resection of mixed pathology of malignant skull base tumors is oncologically feasible and can be accomplished with high GTR rates. There may be a role for EES to reduce operative morbidity and attenuate time in between surgery and adjuvant treatment, which can be augmented through recent mixed reality platforms. Future studies are required to systematically compare the outcomes with those of open surgical approaches.
Multidrug-Resistant Orthopaedic Surgical Site Infections Treated with Linezolid in Four Dogs
Authors: Chou Po-Yen , Yoon Jin , Hersh-Boyle Rebecca A. , Marcellin-Little Denis J. 
Published: August 2020

Abstract
Objective This study aimed to report the adverse drug events and treatment outcome of systemic linezolid therapy to manage multi-drug resistant orthopaedic surgical site infection in dogs.
Materials and Methods Retrospective case review of four dogs that received linezolid to treat surgical site infections after orthopaedic surgery. Reevaluations consisted of a clinical examination or a telephone interview.
Results Serum drug concentrations varied. All dogs showed a temporary resolution of clinical signs of surgical site infection. Two dogs that received linezolid at the previously reported dose developed drug-associated side effects. The side effects were anorexia, nausea, vomiting and regenerative anaemia. All side effects resolved after the discontinuation of linezolid. Surgical site infection recurred in two dogs 52 and 177 days after discontinuing linezolid respectively.
Clinical significance Adverse drug events occurred in dogs receiving oral linezolid at the dosage of 10 to 20 mg/kg. Oral linezolid therapy failed to resolve deep orthopaedic surgical site infections in two out of four dogs. As a tertiary antimicrobial, linezolid should only be used in carefully selected cases while monitoring for drug-associated side effects.
To Evaluate the Solubility of Different Permanent and Temporary Dental Luting Cements in Artificial Saliva of Different pH Values at Different Time Intervals—An In Vitro Study
Authors: Mehta Shak , Kalra Tarun , Kumar Manjit , Bansal Ajay , Avasthi Abhiskek , Malik Shefali Singh 
Published: August 2020

AbstractIntroduction Luting cements are susceptible to attack by moisture during the initial setting period that can result in an increased solubility. The aim of this in vitro study was to evaluate the solubility of different permanent and temporary dental luting cements in artificial saliva of different pH values at different time intervals.Materials and Methods Eight commercial luting cements were used. Out of which five were permanent cements (Rely X lute2, zinc phosphate cement, zinc polycarboxylate cement, Rely X U-200, GC GIC) and three temporary cements (ZOE, Oratemp NE, Temposil). A total of 200 samples were made into 25 specimens of each cement (five samples for each study solution group). The samples were made of dimension 20 mm × 1.5 mm in the metal mold. Once the cements were set, they were removed and after 3 minutes of removal they were placed in the incubator at 37°C ± 1 for 1 hour. Specimens of each cement type were separated into five groups for evaluation and comparison in distilled water and artificial saliva with four different pH values (pH 3, pH 5, pH 7, and pH 9). Percentage of solubility was calculated as 100% times weight loss divided by initial weight of the specimen.Results When all permanent cements were tested the result showed that Rely X U-200 showed least dissolution even after 28 days, followed by Rely X lute-2, then Glass ionomer cement then zinc polycarboxylate cement and then zinc phosphate cement which gave maximum dissolution.Conclusion When all temporary cements were tested the result showed that Temposil showed least dissolution even after 28 days, followed by OraTemp NE, compared with zinc oxide eugenol which gave maximum dissolution.
To Establish Cephalometric Floating Norms as a Guide toward Harmonious Cranial Individual Pattern among North Indian Adults
Authors: Mittal Sanjay , Chawla Dipti , Bhullar Mandeep , Aggarwal Isha , Palkit Tanzin , Chhatwalia Sumit 
Published: August 2020

Abstract
Introduction Floating norms put us at ease while diagnosing and establishing a treatment plan for an individual with abnormal skeletal pattern. It uses the variability of the associations among appropriate cephalometric variables and later on the basis of a regression model by combination of both skeletal parameters which are sagittal and vertical and construct a harmony box which make diagnosis straightforward. This study aims to establish floating cephalometric norms for the describing individual craniofacial skeletal pattern among North Indian Adults as an additional diagnostic tool for orthodontic treatment planning.
Materials and Methods The study includes North Indian adults in age range of 17 to 25 years. A total of 30 patients were selected and were subjected to cephalometric evaluation. Various angular measurements viz., SNB (sella-nasion-point B), NL-NSL (maxillary line-nasion sella line), ML-NSL (mandibular line-nasion sella line), N–S–Ba (nasion-sella-basion), SNA (sella-nasion-point A), and ML-NL (mandibular line-maxillary line) were considered for designing harmony box for North Indian adults.
Results The results of the study were subjected to various statistical analyses. SNB served as the independent variable and NL-NSL, NSBa, ML-NSL, ML-NL, and SNA were made the dependent variable due to lesser R2 values in multiple regression analysis. Correlation between some of the variables, such as (SNA–SNB, ML-NSL–NL-NSL, and ML-NSL–ML-NL), in the present North Indian sample showed positive correlation among each other and were statistically significant (p = 0.000). When compared with the other similar studies done previously, least variability was seen with the Segner study and maximum variability was seen with Thilander’s study.
Conclusion The analysis of the individual craniofacial pattern by means of floating norms appears to provide a helpful method in determining the parameters responsible for the skeletal disharmony, thus representing a viable option for additional diagnostic tool in orthodontic and orthopaedic/surgical treatment planning.
Vertical Transmission of SARS-CoV-2 (COVID-19): Are Hypotheses More than Evidences?
Authors: Auriti Cinzia , De Rose Domenico Umberto , Tzialla Chryssoula , Caforio Leonardo , Ciccia Matilde , Manzoni Paolo , Stronati Mauro 
Published: August 2020

In spite of the increasing, accumulating knowledge on the novel pandemic coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), questions on the coronavirus disease-2019 (COVID-19) infection transmission from mothers to fetuses or neonates during pregnancy and peripartum period remain pending and have not been addressed so far. SARS-CoV-2, a RNA single-stranded virus, has been detected in the amniotic fluid, in the cord blood and in the placentas of the infected women. In the light of these findings, the theoretical risk of intrauterine infection for fetuses, or of peripartum infection occurring during delivery for neonates, has a biological plausibility. The extent of this putative risk might, however, vary during the different stages of pregnancy, owing to several variables (physiological modifications of the placenta, virus receptors' expression, or delivery route). This brief review provides an overview of the current evidence in this area. Further data, based on national and international multicenter registries, are needed not only to clearly assess the extent of the risk for vertical transmission, but also to ultimately establish solid guidelines and consistent recommendations.
Key Points