bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying and selecting implementation theories, models and frameworks: a qualitative study to inform the development of a decision support tool
Authors: Strifler Lisa , Barnsley Jan M. , Hillmer Michael , Straus Sharon E. 
Published: November 2019

Abstract
Background Implementation theories, models and frameworks offer guidance when implementing and sustaining healthcare evidence-based interventions. However, selection can be challenging given the myriad of potential options. We propose to develop a decision support tool to facilitate the appropriate selection of an implementation theory, model or framework in practice. To inform tool development, this study aimed to explore barriers and facilitators to identifying and selecting implementation theories, models and frameworks in research and practice, as well as end-user preferences for features and functions of the proposed tool.Methods We used an interpretive descriptive approach to conduct semi-structured interviews with implementation researchers and practitioners in Canada, the United States and Australia. Audio recordings were transcribed verbatim. Data were inductively coded by a single investigator with a subset of 20% coded independently by a second investigator and analyzed using thematic analysis.Results A total of 24 participants identified characteristics of the individual or team conducting implementation and characteristics of the implementation theory, model or framework as major categories of barriers/facilitators to inform tool development. Major barriers to selection included inconsistent terminology, poor fit with the implementation context and limited knowledge about and training in existing theories, models and frameworks. Major facilitators to selection included the importance of clear and concise language and evidence that the theory, model or framework was applied in a relevant health setting or context. Participants were enthusiastic about the development of a decision support tool that is user-friendly, accessible and practical. Preferences for tool features included key questions about the implementation intervention or project (e.g., purpose, stage of implementation, intended target for change) and a comprehensive list of relevant theories, models and frameworks to choose from along with a glossary of terms and the contexts in which they were applied.Conclusions An easy to use decision support tool that addresses key barriers to selecting an implementation theory, model or framework in practice may be beneficial to individuals who facilitate implementation practice activities. Findings on end-user preferences for tool features and functions will inform tool design and development through a user-centered approach.
Could electronic information systems enhance the quality of Aboriginal health promotion? Findings of an audit of Aboriginal health programs in the Northern Territory of Australia
Authors: Percival Nikki Ann , Boucher Priscilla , Conte Kathleen , Robertson Kate , Cook Julie 
Published: November 2019

Abstract
Background: In Australia, health services are seeking innovative ways to utilize data available in electronic patient information systems, such as Electronic Health Records, to report on, and improve, the quality of health care delivery and health system performance for Aboriginal Australians. These systems provide a valuable source of information on delivery of health care to individuals but are rarely designed for community-level health services, such as health promotion and disease prevention projects. Therefore, research about the use of information systems in health promotion and the potential to report on health promotion quality has received little attention in the academic literature. This study utilizes data stored in a specifically designed, commercially available, health promotion information system (QIPPS) to examine the potential for reporting and improving Aboriginal health promotion. Methods: A structured audit tool was used to extract information from a sample of 39 health promotion projects delivered between 2013 and 2016 in Aboriginal communities of the Northern Territory. Project level data were aggregated and reported as best practice indicators of Aboriginal health promotion quality. Qualitative text describing community participation in health promotion were also captured. Results: QIPPS provided an organized data source on a vast array of health promotion project information for secondary analysis. Using a structured data collection tool enabled project level information to be aggregated at a system-wide level and identified gaps in quality indicators. Information about some aspects of health promotion, like community participation in project planning, was described in detail such that it could be used for quality improvement purposes, however, information about other areas, particularly during project implementation and evaluation, was limited. Conclusion: Project information stored in a specifically designed health promotion electronic information systems can be used to report on and improve Aboriginal health promotion efforts. Data availability and quality were limiting factors for reporting health promotion quality. Strategies to improve the quality and accuracy of data entry together with the use of quality improvement approaches are needed to reap the potential benefits of health promotion information systems.
Silver diamine fluoride (SDF) used in childhood caries management has potent antifungal activity against oral Candida species
Authors: Fakhruddin Kausar Sadia , Samaranayake Lakshman , Egusa Hiroshi , Ngo Hien Chi , Thenmozhi Venkatachalam , Panduwawala Chamila 
Published: November 2019

Abstract
Background The microbiome of Severe-Early Childhood Caries (S-ECC), is characterized by an ecosystem comprising bacterial and fungal species, with a predominance of Candida species. Hence, an anti-cariogen effective against both bacteria and fungi would be valuable in the management of S-ECC.Methods Here we evaluate the antifungal effect of silver diamine fluoride (SDF) against 35-clinical yeast isolates (Ten-each of C. albicans , C. krusei, C. tropicalis and five C. glabrata strains) from dentinal caries-lesions from S-ECC.Results Disc-diffusion and time-kill assays as well as MIC 50 and MIC 90 evaluations against therapeutic concentrations confirmed the broad-spectrum anti-candidal potency of SDF. Ultrastructural images revealed morphologic aberrations of yeast-cell walls on exposure to SDF. All C. krusei and C. glabrata isolates were significantly more sensitive to SDF, relative to the standard antifungal fluconazole.Conclusions Our data, for the first time, elucidate the antifungal potency of SDF, in addition to its known antibacterial activity, in the management of S-ECC.
Effects of Cellulase on the Chemical Compositions Characteristics and Microbial Community of Saline-alkali Land Alfalfa Silage
Authors: Lu Qiang , Ge Gentu , Cheng Qiming , Hou Meiling , Jia shan Yu 
Published: November 2019

Abstract
Background We aim to assess the nutritional quality of alfalfa in saline-alkali and the main fermenting microorganisms acting on alfalfa in saline-alkali soils.Results In this study, We tested the nutrient composition and microbial community of Zhongmu No. 3 (salt-tolerant) alfalfa, including the nutritional fermentation quality and microbial diversity analysis of alfalfa before and after ensiling (30 days and 60 days). Then we got closely genus that related to saline-alkali soils.The validity of the microbiological data was confirmed by alpha diversity analysis. From the Microbial network, we obtained the difference of the saline-type mantle type.Conclusions we found that the silage quality of Saline-alkali alfalfa can be ensured by anaerobic fermentation with addition. The LABs that play a major role in the saline alkaline alfalfa silage are Lactobacillus, lactococcus and enterococcus.
Biocontrol of tomato bacterial wilt by a new strain Bacillus velezensis FJAT-46737 and its lipopeptides
Authors: Chen Meichun , Wang Jieping , Liu Bo , Zhu Yujing , Xiao Rongfeng , Yang Wenjing , Ge Cibin , Chen Zheng 
Published: November 2019

Abstract
Background There is an urgent need to discover alternative antimicrobial agents to control bacterial wilt. The objectives of this study were to report a new lipopeptide-producding biocontrol strain FJAT-46737 and its lipopeptides, and to investigate their antagonistic effects.Results Based on the whole genome sequence analysis, the new strain FJAT-46737 was finally identified as Bacillus velezensis and seven gene clusters that responsible for synthesis of bioactive secondary metabolite in the FJAT-46737 were predicted. Antimicrobial results demonstrated that FJAT-46737 exhibited broad-spectrum antimicrobial activities in vitro against bacteria and fungi. The pot experiments showed that the tomato bacterial wilt control efficiencies of the whole cultures, the 2-fold diluted supernatants and the crude lipopeptide of FJAT-46737 were 66.2%, 82.0%, and 96.2%, respectively. The above results suggested that one of the antagonistic mechanisms of FJAT-46737 was secretion of lipopeptides that consisted of iturins, fengycins and surfactins. The crude lipopeptides had significant antagonistic activities on several pathogen in a dosage-dependent manner, and the fengycins confirmed to play a major role in antibacterial abilities in vitro of the lipopeptides against Ralstonia solanacearum . Furthermore, it was found that the rich organic nitrogen sources (expecially yeast extracts) in the media were benificial for FJAT-46737 to produce fengycin and surfactin. The secretion of these two lipopeptides were also adjusted by the culture temperature: the content of the fengycins decreased by 96.6% and that of the surfactins ascended by 59.9% from 20 o C to 40 o C. And 20 o C~25 o C is the suitable temperature for FJAT-46737 to produce lipopeptide.Conclusions The B. velezensis strain FJAT-46737 and its lipopeptides would used as new sources of potential biocontrol agents against plant pathogens, especially the bacterial wilt pathogen R. solanacearum .
The adverse maternal and perinatal outcomes of adolescent pregnancy: a cross sectional study in Hebei, China
Authors: Zhang Ting , Zhang Yingkui , Wang Huien , Yang Yue , Tang Zengjun , Wang Li 
Published: November 2019

Abstract
Background Adolescent pregnancy was a serious problem in the world, especially in developing countries. While Chinese adolescent population were about 1/4 of the total population, but have few studies focused on adolescence pregnancy in China. Thus, we aimed to clarify pregnant adverse maternal and perinatal outcomes among adolescent women by analyzing the data of childbirth in Hebei Province, a large population province in China.Methods We used the Hebei Provincial Maternal and Child Health Center Perinatal Database, including 238,598 singleton pregnancy women aged 10-34 between 2013 and 2017. They were divided into two groups: Adolescent group (10-19 years) and adult group (20-34 years), compared risk of adverse pregnancy outcomes using Poisson regression, Univariate and Multivariate Logistic Regression.Results Adolescents pregnancy women had a lower risk of cesarean delivery [adjusted risk ratio (aRR): 0.75, 95% confidence interval: 0.70-0.80] and gestational diabetes mellitus (GDM) (aRR: 0.55, 95% CI: 0.41-0.73). Adolescent pregnancy had an increased risk of preterm birth (aRR: 1.76, 95% CI: 1.54-2.01), small for gestational age (SGA) (aRR: 1.19, 95% CI: 1.08-1.30), stillbirth (aRR: 2.58, 95% CI: 1.83-3.62), neonatal death (aRR: 2.63, 95% CI: 1.60-4.32). And the risk of preeclampsia, HELLP syndrome, placenta previa, placental abruption, postpartum hemorrhage were negatively associated with adolescent pregnancy. There was a lower morbidity of anemia and a higher maternal mortality in adolescent pregnancy (P<0.05). However, there were no difference in the effects of anemia (aRR: 1.04, 95% CI: 0.96-1.12) and maternal mortality (aRR: 2.61, 95% CI: 0.20-33.77) after adjusting for confounding factors.Conclusions Adolescent pregnancy was related to perinatal adverse outcomes, but was not related to maternal adverse outcomes. Adolescent pregnancy was a protective factor for caesarean section and GDM, independent risk factor for preterm birth, SGA, stillbirth and neonatal death.
Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography.
Authors: Abe Maiko , Omodaka Kazuko , Kikawa Tsutomu , Nakazawa Toru 
Published: November 2019

Abstract
Background: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH), a disease which is important to differentiate from glaucoma. Methods: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure (IOP) less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) in the overall, quadrants, and 12 clock-wise sectors. RPC density was compared in normal and SSOH subjects with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve. Results: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density in the overall area (p < 0.001) and superior (p < 0.001), nasal (p < 0.001), and inferior (p < 0.001) quadrants was significantly lower in the SSOH group, but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o’clock sector (0.896). Conclusions: Low RPC density was found in the three non-temporal quadrants of the optic nerve head. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.
Role of vascular endothelial growth factor-165b in the breakdown of the blood-retinal barrier after acute high intraocular pressure in rats
Authors: Shen Jing , Yi Xi-Nan , Liu Zheng-Hai , Li Min , Liu Wei-Xian , Sun Hong-Liang , Wang Ling , Zhang Quan-peng 
Published: November 2019

Abstract
Background: The blood-retinal barrier (BRB) is essential in maintaining the retinal homeostasis of the microenvironment, previous studies have found that BRB breakdown occurs after acute high intraocular pressure (HIOP) in rats, elevated intraocular pressure can induce upregulation of vascular endothelial growth factor-165b (VEGF-165b) protein in the retina, but the role of VEGF-A165b in BRB breakdown after acute HIOP is still undetermined. Methods: In this study, the rat acute HIOP model was established before and after intravitreous injection of anti-VEGF-165b antibody. The expression of VEGF-165b and ZO-1 in rat retina was detected by immunohistochemistry or western blotting, and the breakdown of BRB was detected by Evans blue (EB) dye. Results: The normal retina of rats expressed VEGF-165b protein, which was mainly located in the retinal ganglion cell (RGC) layer and the inner nuclear layer and was coexpressed with tight junction protein ZO-1. After acute HIOP, the expression of VEGF-165b was upregulated (P < 0.01); The expression of ZO-1 was downregulated (P < 0.01) at 12 h and then recovered at 3 d; EB leakage increased, peaking at 12 h (P < 0.01). After intravitreous injection of anti-VEGF-165b antibody, the expression of VEGF-165b protein was significantly downregulated (P < 0.01); and the downregulation of the expression of ZO-1 was more obvious (P < 0.01); EB leakage became more serious, peaking at 3 d (P < 0.01). EB analysis also showed that EB leakage in the peripheral retina was greater than that in the central retina (P < 0.01). Conclusions: The endogenous VEGF-165b protein may protect the BRB from acute HIOP by regulating the expression of ZO-1. The differential destruction of BRB after acute HIOP may be related to the selective loss of RGCs.
Pseudonajide is an antibiotic peptide derived from snake venom that alter cell wall and membrane integrity interfering on biofilm formation.
Authors: Schneider Rafael , Primon-Barros Muriel , Von Borowski Rafael Gomes , Chat Sophie , Gillet Reynald , Macedo Alexandre José 
Published: November 2019

Abstract
Background
The increase of bacterial resistance phenotype cases is a global health problem. New strategies in scientific community must be explored in order to create new treatment alternatives. Animal venoms are a good source for antimicrobial peptides (AMPs), which are excellent candidates for new antimicrobial drug development. These molecules have highly diverse targets in prokaryotic cells, making resistance phenotype development more difficult.
Results
In this study we present a peptide of just 11 amino acids which has antimicrobial and antibiofilm activity against Staphyloccocus epidermidis. Named pseudonajide, it is derived from Pseudonaja textilis venom. Pseudonajide was selected based on the sequence alignments of various snake venom peptides that displayed activity against bacteria. Several concentrations of pseudonajide were tested in antibiofilm activity essay, it was detected that 25 µM was the best minimal concentration for biofilm inhibiting activity. Microscopy analysis demonstrates that pseudonajide interacts with the bacterial cell envelope, disrupting the cell wall and membrane leading to morphological defects in prokaryotes.
Conclusions
Our results suggest that pseudonajide’s positives charges interacts with negative charged cell wall components of S. epidermidis. Leading to cell damage and biofilm formation inhibition.
Prevalence and risk factors for micronutrient deficiencies in pregnant women at Cayenne maternity, French Guiana
Authors: Duclau Amandine , Abad Fanny , Adenis Antoine , Leneuve-Dorilas Malika , Nacher Mathieu 
Published: November 2019

Abstract
Background Involved in physical and brain development, immune system functioning and various metabolic processes, micronutrients have profound health effects. The nutritional status of the pregnant woman is a major determinant of fetal health. French Guiana has the highest annual population growth rate. Social inequalities, cultural practices and parasitoses in French Guiana could affect the prevalence of these deficiencies. The main objective was to estimate the prevalence of micronutrient deficiency among pregnant women in French Guiana. The secondary objective was to identify socio-demographic, dietary, obstetric and neonatal risk factors associated with deficiencies.Methods Pregnant woman over 22 weeks of pregnancy hospitalized for delivery at the Obstetrical Emergency Department of the Hospital Center in Cayenne from May 2018 to March 2019. A socio-demographic and food questionnaire was administered. Medical data were collected from the medical records. Blood and urine samples were taken. The descriptive analysis used the Student and Chi2 tests. Prevalence ratios were obtained a Poisson regression.Results A total of 341 women were included. The majority were born in Haiti (39%) and French Guiana (34%). At least one micronutrient deficiency was documented in 81% of women. Women receiving State Medical Aid had a 35% greater risk of deficiency during pregnancy compared to those with both normal and complementary health insurance. (PR=1.35 95% CI (1.12;1.63) p-value=0. 002)Conclusions Micronutrient deficiencies in pregnant women in French Guiana are a real public health problem, a fact that was previously overlooked in a context of rising obesity. A varied and balanced diet remains the most effective solution to prevent these deficiencies. In French Guiana, a region where precariousness and obesity are widespread, nutritional care seems urgent.
Plasmodium vivax severe imported malaria in two migrants in France
Authors: Izri Arezki , Cojean Sandrine , Leblanc Claire , Cohen Yves , Bouchaud Olivier , Durand Remy 
Published: November 2019

Abstract
Background: With less than one severe case per year in average, P. vivax is very rarely associated with severe imported malaria in France. We report two cases of P. vivax severe malaria in patients with no evident co-morbidity. Interestingly, both cases did not occur at the primary infection but during relapses. Case presentations Patient 1 A 27-year old male, born in Afghanistan and living in France since 2012, was admitted on August 2015 to our hospital because of abdominal pain, intense headache, fever and hypotension. The patient was hemodynamically unstable despite 5 liters of filling solution. A thin blood film showed Plasmodium vivax trophozoites within the red blood cells. To take care of the septic shock, the patient was given rapid fluid resuscitation, norepinephrine (0.5 mg/h), and intravenous artesunate. Nested polymerase chain reactions of the SSUrRNA gene were negative for P. falciparum but positive for P. vivax. The patient became apyretic in less than 24H and the parasitaemia was negative at the same time. Patient 2 A 24-year old male, born in Pakistan and living in France, was admitted on august 2016 to our hospital because of fever, abdominal pain, headache, myalgia, and nausea. The last travel of the patient in a malaria endemic area occurred in 2013. A thin blood film showed Plasmodium vivax trophozoites within the red blood cells. The patient was treated orally by artenimol-piperaquine and recovered rapidly. Nine months later, the patient returned to our hospital with a relapse of P. vivax malaria. The malaria episode was uncomplicated and the patient recovered rapidly. Three months later, the patient came back again to our hospital with a third episode of P. vivax malaria. Following a rapid hemodynamic deterioration, the patient was transferred to the intensive care unit of the hospital. In all the patient received 10 liters of filling solution to manage the septic shock. After 5 days of hospitalization and a specific treatment, the patient was discharged in good clinical conditions. Conclusion: Clinicians should be aware of the potential severe complications associated with P. vivax in imported malaria, even though the primary infection is uncomplicated.