bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Penerapan Etika Birokrasi Dalam Pelayanan Publik Pada Dinas Kependudukan Dan Pencatatan Sipil Kota Gunungsitoli
Authors: Zega Yamolala 
Published: November 2019

Pelayanan dari para aparat birokrasi pemerintah Kota Gunungsitoli sangat diharapkan dapat melaksanakan penerapan etika birokrasi dalam pelayanan publik secara nyata sehingga tertib administrasi kependudukan dapat terwujud secara efektif dan efisien dengan tidak mengabaikan nilai-nilai moral dan etika birokrasi itu sendiri. Perumusan masalah yaitu bagaimana penerapan etika birokrasi dalam pelayanan publik pada dinas Kependudukan dan Pencatatan Sipil Kota Gunungsitoli. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kualitatif. Dalam penelitian ini, peneliti mengambil sampel sebanyak 32 orang yaitu seluruh pegawai pada Dinas Kependudukan dan Pencatatan Sipil Kota Gunungsitoli. Jenis data yang digunakan yaitu data primer dan data sekunder. Kedua jenis data ini dapat diperoleh dengan cara observasi dan wawancara. Data yang sudah diperoleh maka akan di analisa dengan teknik analisa data dengan metode deduktif dan metode deskriptif. Dari hasil analisis secara deskriptif berdasarkan data sekunder yang diperoleh dari objek penelitian. Sebagaimana dijelaskan pada kajian teori, bahwa indikator Etika Birokrasi Dalam Pelayanan Publik adalah: Penerapan Etika Birokrasi: Kode etik dalam palayanan, Kejujuran dalam pelayanan, Tanggungjawab pelayanan, Disiplin dalam pelayanan, Diskriminatif pelayanan. Pelayanan Publik: Keterbukaan, Keserdehanaan, Kepastian, Keadilan, Keamanan dan kenyamanan, Perilaku petugas pelayanan
A COMMUNICATION AID SYSTEM BY FEATURE EXTRACTION OF ELECTROOCULOGRAPHIC SIGNALS
Authors: Sugi Takenao , Baba Ryosuke , Matsuda Yoshitaka , Goto Satoru , Egashira Naruto , Oishi Ayame , Yamasaki Takao 
Published: November 2019

People with serious movement disabilities due to neurodegenerative diseases have problems in their communication with others. Considerable numbers of communication aid systems have been developed in the past. Especially, some of the systems driven by eye movements are thought to be effective for such people. Electrooculographic (EOG) signal reflects the eye movement and the specific pattern of eye movement can be seen in EOG signals. This paper proposes a communication aid system by extracting the features of EOG. The system consists of a computer, analog-to-digital converter, biological amplifier and two monitors. Two monitors, one for a system user and the other for other people, display the same information. Five items are presented in the monitor, and a user selects those items according to the situation in the communication. Selection of the items is done by combining three eye movements: gaze at left, gaze at right and successive blinks. Basic concept of the communication aid system was designed by taking into account the current state of a subject’s movement disability. Then, the design of a screen and the algorithm for detecting eye movement pattern from EOG were determined by using the data of normal healthy subjects. The system worked almost perfectly for normal healthy subjects. Then, the developed system was operated by a subject with serious movement disability. Parts of the system operation were regarded as satisfactory level, and some miss-operation were also seen.
TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis
Authors: Bovensiepen Claudia S. , Schakat Miriam , Sebode Marcial , Zenouzi Roman , Hartl Johannes , Peiseler Moritz , Li Jun , Henze Lara , Woestemeier Anna , Schramm Christoph , Lohse Ansgar W. , Herkel Johannes , Weiler-Normann Christina 
Published: November 2019

Abstract
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that is believed to be driven by a CD4+ T cell response to liver Ags. However, the pathogenic function of CD4+ effector T cells in AIH is not fully understood. To characterize liver-infiltrating lymphocytes in AIH, we determined the cytokine production of infiltrating cells obtained from biopsy material by quantitative RT-PCR and flow cytometry. A cytokine quantitiative RT-PCR array of AIH specimens revealed that TNF was the most strongly upregulated cytokine, as compared with control livers. To confirm this finding, we determined the frequencies of TNF-producing CD4+ T cells in peripheral blood and in liver biopsy specimens in comparison with those of CD4+ T cells producing IFN-γ or IL-17. In AIH, TNF-producing CD4+ T cells were significantly expanded, both in blood and liver, whereas IL-17–producing CD4+ T cells were not. However, the majority of the TNF-producing CD4+ T cells in AIH also produced IFN-γ, suggesting that TNF producers might represent a pathogenic activation state of Th1 cells. Ag-specific stimulation of PBMC from AIH patients with the AIH-associated autoantigen SEPSECS resulted in significant TNF production only in patients manifesting SLA/LP autoantibodies targeting SEPSEC but not in healthy individuals who do not manifest this reactivity. Taken together, our findings indicated that TNF-producing CD4+ T cells are expanded in AIH, both in blood and in liver. TNF-producing CD4+ T cells in AIH seem to be aberrantly activated Th1 cells. Our findings provide a rationale for therapeutic efforts using TNF blockade in AIH.
Recent precipitation decrease across the western Greenland ice sheet percolation zone
Authors: Lewis Gabriel , Osterberg Erich , Hawley Robert , Marshall Hans Peter , Meehan Tate , Graeter Karina , McCarthy Forrest , Overly Thomas , Thundercloud Zayta , Ferris David 
Published: November 2019

Abstract. The mass balance of the Greenland Ice Sheet (GrIS) in a warming climate is
of critical interest in the context of future sea level rise. Increased
melting in the GrIS percolation zone due to atmospheric warming over the
past several decades has led to increased mass loss at lower elevations.
Previous studies have hypothesized that this warming is accompanied by a
precipitation increase, as would be expected from the Clausius–Clapeyron
relationship, compensating for some of the melt-induced mass loss throughout
the western GrIS. This study tests that hypothesis by calculating snow
accumulation rates and trends across the western GrIS percolation zone,
providing new accumulation rate estimates in regions with sparse in situ data or
data that do not span the recent accelerating surface melt. We present
accumulation records from sixteen 22–32 m long firn cores and 4436 km of
ground-penetrating radar, covering the past 20–60 years of accumulation,
collected across the western GrIS percolation zone as part of the Greenland
Traverse for Accumulation and Climate Studies (GreenTrACS) project. Trends
from both radar and firn cores, as well as commonly used regional climate
models, show decreasing accumulation rates of 2.4±1.5 % a−1
over the 1996–2016 period, which we attribute to shifting storm tracks
related to stronger atmospheric summer blocking over Greenland. Changes in
atmospheric circulation over the past 20 years, specifically anomalously
strong summertime blocking, have reduced GrIS surface mass balance through
both an increase in surface melting and a decrease in accumulation rates.
El Activismo de las Mujeres en el Movimiento Estudiantil Católico en Uruguay (1968–1973)
Authors: García Lorena 
Published: November 2019

ABSTRACTEste trabajo se propone identificar y analizar el activismo de las mujeres en el movimiento estudiantil católico en Uruguay desde 1968, cuando se celebró la II Conferencia del Consejo Episcopal Latinoamericano en Medellín, hasta 1973 que marcó el inicio de la última dictadura cívico-militar. En particular, se centra en aquellas jóvenes que integraron el Movimiento de Cristianos Universitarios, agrupación proveniente de la Acción Católica especializada. Con sus prácticas cuestionaron los roles tradicionales adjudicados a la mujer en la familia y en la sociedad, así como dentro del catolicismo que enfatizaba su función maternal en desmedro de sus derechos sociales y políticos. En base a una metodología histórica y cualitativa se pone en discusión la documentación con la bibliografía actualizada sobre la temática. Además, se utilizaron entrevistas realizadas a ex integrantes y asesores del movimiento laical de la época.
American Views of the Brazilian Liberationist Church: The Case of Bishop Hélder Câmara, 1964–1972
Authors: Tovar Sigifredo Romero 
Published: November 2019

ABSTRACT
The article explores the American views concerning the progressive wing of the Brazilian Catholic Church during the first years of military dictatorship. It focuses on the case of Bishop Hélder Câmara as perceived by the diplomatic service during the 1964–72 years. It deals with the American perception regarding this religious leader in relation to Church-state relations, his ideological postures, the 1969 murder of his colleague Father Henrique Pereira Neto, political alterations at the end of the 1960s, and his international relevance. The article reveals the aversion of the diplomatic service toward Dom Hélder due to the ideological framework of National Security Doctrine. It also shows variations in the American view regarding the bishop as a consequence of political transitions in 1969–70.
The Return on Investment of Orthopaedic Fellowship Training: A Ten-year Update
Authors: Mead Matthew , Atkinson Theresa , Srivastava Ajay , Walter Norman 
Published: November 2019

Background:
Over 90% of graduating orthopaedic residents now pursue fellowship training, and only 15% of practicing orthopaedic surgeons now characterize themselves as generalists. Fellowship training has significant financial effects due to both opportunity cost of that year of training and changes in compensation throughout one's career. The purpose of this study was to estimate the financial return on investment by pursuing additional training in an orthopaedic fellowship versus general practice.

Methods:
Using described techniques of financial analysis, net present value (NPV), internal rate of return (IRR), and break-even point were estimated over the average working career length of an orthopaedic surgeon. Compensation data were drawn from the American Medical Group Association physician compensation surveys. Seven fellowships were studied and referenced to a career in general orthopaedic practice.

Results:
Fellowship training in spine surgery yields the highest return on investment with a break-even point of 5 years. Adult reconstruction has a positive NPV and IRR, but when corrected for number of hours worked per week offers no productivity advantage to general practice. Sports medicine and trauma offer neutral returns, but when corrected for work hours, NPV and IRR both become negative. Hand, pediatrics, and foot and ankle never break even following the loss of compensation realized during fellowship year.

Discussion:
The recent trend across all medical specialties has been for increased fellowship training and subspecialization. There are numerous reasons to pursue fellowship training, both personal and financial. This study presents an updated estimate of the financial impact of fellowship training in orthopaedics. This analysis demonstrates that selecting different fellowships can generate positive, negative, or neutral financial returns. This study has the potential to influence residents' decisions to pursue general practice versus fellowship training and identifies economic drivers, which may lead to preferential pursuit of certain subspecialties.
Chebyshev type inequalities involving generalized Katugampola fractional integral operators
Authors: Set Erhan , Choi Junesang , Mumcu \.{I}lker 
Published: November 2019

A number of Chebyshev type inequalities involving various fractional integral operators have, recently, been presented.Here, motivated essentially by the earlier works and their applications in diverse research subjects, we aim to establish several Chebyshev type inequalities involving generalized Katugampola fractional integral operator. Relevant connections of the results presented here with those (known and new) involving relatively simpler and familiar fractional integral operators are also pointed out.
Reseña de Álvarez Ramos, Eva y Blasco Pascual, Javier (eds.): "Humanidades Digitales. Retos, Recursos y Nuevas Propuestas"
Authors: Sánchez Martín Francisco Javier 
Published: November 2019

El objetivo primero de esta reseña consiste en acercarnos a una publicación dentro de un campo que está experimentando un importante desarrollo, pero que, en el caso de la lengua española, aún necesita de avances en las reflexiones sobre las tareas que facilitan los recursos digitales, no solo para ayudar al proceso de digitalización con el fin de seguir comprendiendo nuestro pasado, sino para crear, merced a la tecnología, nuevos materiales didácticos para el presente, a la vez que propiciar el diálogo académico abierto para interpretar los enfoques teóricos y metodológicos del futuro cercano. Además, con esta reseña se pretende facilitar la consulta de los trabajos publicados en estas actas, de forma que puedan observarse aquellos aspectos en los que la disciplina Humanidades Digitales debe consolidarse o aquellos otros en los que debe reconfigurarse, o en su caso, abandonarse por no ser específicos o representativos para el desarrollo de las humanidades digitales.
Intranasal midazolam as first‐line inhospital treatment for status epilepticus: a pharmaco‐EEG cohort study
Authors: Kay Lara , Merkel Nina , von Blomberg Anemone , Willems Laurent M. , Bauer Sebastian , Reif Philipp S. , Schubert‐Bast Susanne , Rosenow Felix , Strzelczyk Adam 
Published: November 2019

AbstractObjectiveWe sought to evaluate the efficacy and tolerability of intranasal midazolam (in‐MDZ) as first‐line inhospital therapy in patients with status epilepticus (SE) during continuous EEG recording.MethodsData on medical history, etiology and semiology of SE, anticonvulsive medication usage, efficacy and safety of in‐MDZ were retrospectively reviewed between 2015 and 2018. Time to end of SE regarding the administration of in‐MDZ and ß‐band effects were analyzed on EEG and with frequency analysis.ResultsIn total, 42 patients (mean age: 52.7 ± 22.7 years; 23 females) were treated with a median dose of 5 mg of in‐MDZ (range: 2.5–15 mg, mean: 6.4 mg, SD: 2.6) for SE. The majority of the patients suffered from nonconvulsive SE (n = 24; 55.8%). In total, 24 (57.1%) patients were responders, as SE stopped following the administration of in‐MDZ without any other drugs being given. On average, SE ceased on EEG at 05:05 (minutes:seconds) after the application of in‐MDZ (median: 04:56; range: 00:29–14:53; SD:03:13). Frequency analysis showed an increased ß‐band on EEG after the application of in‐MDZ at 04:07 on average (median: 03:50; range: 02:20–05:40; SD: 01:09). Adverse events were recorded in six patients (14.3%), with nasal irritations present in five (11.9%) and prolonged sedation occurring in one (2.6%) patient.ConclusionsThis pharmaco‐EEG–based study showed that in‐MDZ is effective and well‐tolerated for the acute treatment of SE. EEG and clinical effects of in‐MDZ administration occurred within 04:07 and 5:05 on average. Intranasal midazolam appears to be an easily applicable and rapidly effective alternative to buccal or intramuscular application as first‐line treatment if an intravenous route is not available.
Impact of FcγR variants on the response to alemtuzumab in multiple sclerosis
Authors: Keller Christian W. , Ruck Tobias , McHugh Donal , Pfeuffer Steffen , Gross Catharina C. , Korsukewitz Catharina , Melzer Nico , Klotz Luisa , Meuth Sven G. , Münz Christian , Nimmerjahn Falk , Wiendl Heinz , Lünemann Jan D. 
Published: November 2019

AbstractAllelic variants of genes encoding for the Fc gamma receptors IIIA and IIA have been associated with the clinical response to cell‐depleting antibodies in lymphoma patients. Here, we tested the hypothesis that FCGR3A and FCGR2A high‐affinity polymorphisms predict clinical outcomes to alemtuzumab therapy in 85 patients with relapsing‐remitting multiple sclerosis. No differences in clinical and MRI‐based efficacy parameters, the development of severe infusion‐associated reactions and secondary autoimmune diseases during a 2 year follow‐up was observed based on FCGR3A or FCGR2A polymorphisms. This study does not support the use of FCGR genetic variants to predict clinical outcomes to alemtuzumab.
Osterix‐mCherry Expression Allows for Early Bone Detection in a Calvarial Defect Model
Authors: Strecker Sara E. , Unterman Shimon , Charles Lyndon F. , Pivovarchick Dmitry , Maye Peter F. , Edelman Elazer R. , Artzi Natalie 
Published: November 2019

AbstractThe process of new bone formation following trauma requires the temporal recruitment of cells to the site, including mesenchymal stem cells, preosteoblasts, and osteoblasts, the latter of which deposit minerals. Hence, bone repair, a process that is assessed by the extent of mineralization within the defect, can take months before it is possible to determine if a treatment is successful. Here, a fluorescently tagged Osterix, an early key gene in the bone formation cascade, is used as a predictive measure of bone formation. Using a calvarial defect model in mice, the ability to noninvasively track the Osterix transcription factor in an Osterix‐mCherry mouse model is evaluated as a measure for bone formation following treatment with recombinant human Bone‐Morphogenetic‐Protein 2 (rhBMP‐2). Two distinct delivery materials are utilized, an injectable nanocomposite hydrogel and a collagen sponge, that afford distinct release kinetics and it is found that cherry‐fluorescent protein can be detected as early as 2 weeks following treatment. Osterix intensity correlates with subsequent bone formation and hence can serve as a rapid screening tool for osteogenic drugs or for the evaluation and optimization of delivery platforms.
Condensation‐Driven Chondrogenesis of Human Mesenchymal Stem Cells within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical Properties
Authors: Yang Yuanheng , Liu Yuwei , Lin Zixuan , Shen He , Lucas Caitlin , Kuang Biao , Tuan Rocky S. , Lin Hang 
Published: November 2019

AbstractMesenchymal stem cells (MSCs) represent a promising cell source to regenerate injured cartilage. In this study, MSCs are cultured under confluent conditions for 10 days to optimize the deposition of the extracellular matrix (mECM), which will serve as the scaffold to support MSC chondrogenesis. Subsequently, the MSC‐impregnated mECM (MSC‐mECM) composite is briefly treated with trypsin, allowing the MSCs to adopt a round morphology without being detached from their own mECM. The constructs are then cultured in a chondrogenic medium. Interestingly, after trypsin removal, the treated MSCs undergo an aggregation process, mimicking mesenchymal condensation during developmental chondrogenesis, specifically indicated by peanut agglutinin staining and immunodetectable N‐cadherin expression, followed by robust chondrogenic differentiation. In comparison to conventional pellet culture, chondrogenically induced MSC‐mECM displays a similar level of chondrogenesis, but with significantly reduced hypertrophy. The reparative capacity of the MSC‐mECM derived construct is assessed using bovine cartilage explants. Mechanical testing and histology results show that engineered cartilage from MSC‐mECM forms better integration with the surrounding native cartilage tissue and displays a much lower hypertrophic differentiation than that from pellet culture. Taken together, these findings demonstrate that MSC‐mECM may be an efficacious stem cell‐based product for the repair of hyaline cartilage injury without the use of exogenous scaffolds.
Biomaterial‐Induction of a Transplantable Angiosome
Authors: Charbonnier Baptiste , Maillard Sophie , Sayed Omaer , Baradaran Aslan , Mangat Harshdeep , Dalisson Benjamin , Zhang Zishuai , Zhang Yu‐Ling , Hussain Sabah N. A. , Mayaki Dominique , Seitz Hermann , Harvey Edward J. , Gilardino Mirko , Gbureck Uwe , Makhoul Nicholas , Barralet Jake 
Published: November 2019

AbstractCreating transplantable vascular networks (angiosomes) that are fed and drained by vessels large enough to be surgically reconnected is key to harnessing the potential of regenerative medicine and advancing reconstructive surgical techniques. Currently, the only way to create a new angiosome is nontrivial and involves pressurizing a vein graft by its surgical attachment to an artery forming an arteriovenous loop (AVL). Material induction of a venous angiosome is reported, by placement of a 3D printed microporous monetite scaffold around a vein and its transplantability is further demonstrated. When the transplanted venosome is cut, it bleeds, illustrating potential reconstructive functionality. The volume of blood vessels generated by biomaterial‐induction is as great as by AVL. Direct contact of the material with the vein does not appear to be critical to luminal sprouting, and wrapping the implant in a silicone membrane significantly reduces sprouting. Pilot studies with microporous polymeric scaffolds induce far less vascular invasion. After 4 weeks, monetite scaffolds are extensively vascularized and can be transplanted to an arterial vessel. This report is significant since a lack of tools to control vascular generation is an impediment to the treatment of several conditions that give rise to tissue ischemia and tissue reconstruction.
Boosting H2O2‐Guided Chemodynamic Therapy of Cancer by Enhancing Reaction Kinetics through Versatile Biomimetic Fenton Nanocatalysts and the Second Near‐Infrared Light Irradiation
Authors: Wang Tingting , Zhang Hao , Liu Hanghang , Yuan Qiang , Ren Feng , Han Yaobao , Sun Qiao , Li Zhen , Gao Mingyuan 
Published: November 2019

AbstractFenton reaction–based chemodynamic therapy (CDT) has attracted considerable attention for tumor treatment, because the Fenton reaction can degrade endogenous H2O2 within the tumor to form reactive oxygen species (ROS) to kill cancer cells. The kinetics of the Fenton reaction has significantly influenced its treatment efficacy. It is crucial to enhance the reaction kinetics at the maximum H2O2 concentration to quickly produce vast amounts of ROS to achieve treatment efficacy, which to date, has not been realized. Herein, reported is an efficacious CDT treatment of breast cancer using biomimetic CS‐GOD@CM nanocatalysts, which are rationally designed to significantly boost the Fenton reaction through improvement of H2O2 concentration within tumors, and application of the second near‐infrared (NIR‐II) light irradiation at the maximum concentration, which is monitored by photoacoustic imaging. The biomimetic nanocatalysts are composed of ultra‐small Cu2−xSe (CS) nanoparticles, glucose oxidase (GOD), and tumor cell membrane (CM). The nanocatalysts can be retained in tumor for more than two days to oxidize glucose and produce an approximately 2.6‐fold increase in H2O2 to enhance the Fenton reaction under the NIR‐II irradiation. This work demonstrates for the first time the CDT treatment of cancer enhanced by the NIR‐II light.