bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wild Plants and the Food-medicine Continuum – An Ethnobotanical Survey in Chapada Diamantina (Northeastern Brazil)
Authors: Medeiros Patrícia Muniz , Figueiredo Karina Ferreira , Gonçalves Paulo Henrique Santos , Caetano Roberta Almeida , Santos Élida Monique da Costa , Paula Marcelo , Mapeli Ana Maria 
Published: December 2020

Abstract
Background: Ethnobotanical research has demonstrated that several wild food plants (WFP) are used for medicinal purposes. Therefore, in addition to constituting an important source of nutrients, WFP can be used to help treat and avoid health problems. This study sought to characterize the traditional use of plants considered simultaneously as food and medicine by local specialists in the community of Caeté-Açu, which borders Chapada Diamantina National Park (NE Brazil). We also sought to identify the drivers of species’ cultural importance. Methods: We selected local specialists based on a snowball sample and used a free-listing technique to register the wild plants they knew that are both edible and medicinal. Then, we asked the specialists to rank each plant component cited according to the following attributes: (1) ease of acquisition, (2) taste, (3) smell, (4) nutritional value, and (5) medicinal value. We used multiple regression to determine the drivers of popularity and frequency of use. Results: The most culturally salient species was Anredera cordifolia (Ten.) Steenis. The main medicinal effects associated with this species were related to body strengthening, intestinal regulation, and stomach issues. The most salient used species were those that were easiest to acquire and had the highest perceived nutritional values. Conclusion: It is likely that the sociocultural backgrounds of the respondents (elders, former miners or descendants of miners) and the historical importance of wild food plants to local diets increased the predictive power of the perceived nutritional potential and ease of acquisition of these plants.
Traditional uses of Detarium Microcarpum Guill. &amp; Perr. (Fabaceae) and Potential for its Valorisation as Fuelwood
Authors: SINADOUWIROU Théophile Abaro , Dicko Aliou , Biaou Samadori Sorotori Honoré , Assede Eméline , Natta Armand Kuyema 
Published: December 2020

Abstract
Background: Forest management can be sustainable if it integrates social, cultural and economic values ​​that local communities associate with forest resources in a given area. Detarium microcarpum Guill. & Perr. (Fabaceae), also known as small detar or sweet detar, is a common multiuse small tree of Sudanese and Sudano-Guinean savannahs with high potential for use as fuelwood or fruit tree but little valued in forestry programs. The present countrywide study aims to assess the compatibility of current local uses of Detarium microcarpum with its promotion as fuelwood and to determine the most suitable areas for its integration into forest management programs. Methods: An ethnobotanical survey was conducted on the basis of a semi-structured questionnaire among 1074 people selected randomly in 10 of the 12 departments of Benin where the species is present. Factors determining Detarium microcarpum use as fuelwood were identified through a binary logistic regression. A Factorial Correspondence Analysis established the relationship between socio-cultural groups and the use of Detarium microcarpum parts or organs.Results: A total of 671 people (62.47%) know and use at least one part of Detarium microcarpum. The trunk and branches are the most used organs (35.12% of respondents), primarily as fuelwood. The determinants of Detarium microcarpum use as fuelwood are the phytogeographic district (a proxy for the resource availability), gender, sociolinguistic group, and educational level. Detarium microcarpum is more used as fuelwood by women belonging to the sociolinguistic groups Gourmatche, Kounteni, Boo, Monkole, Gando and Bariba. In addition, the use of Detarium microcarpum as fuelwood decreases with the educational level and is more pronounced in the phytogeographical districts of Borgou-Nord, Atacora chain and Borgou-Sud, covering together about 63% of the national territory and representing 28% of its population. Conclusions: This study confirms the potential of Detarium microcarpum as fuelwood, particularly in northern Benin, and calls for further research on the species local abundance and structure, regeneration, silviculture and management mode.
To: Malaria Journal Malaria Prevention and Treatment in Migrant Agricultural Workers in Dangur District, Benishangul-Gumuz, Ethiopia: Social and Behavioral Aspects
Authors: Wondimu Yehualashet Tadesse , Irish Seth , Chibsa Sheleme , Dugassa Sisay , Lorenz Lena , Gebreyohannes Asfawesen , Teka Hiwot , Solomon Hiwot , Gezahegn Eshetu , Petros Yonas , Haile Mesfin , Eshetu Mesfin , Murphy Matthew 
Published: December 2020

Abstract
Background: Sixty percent of the Ethiopia population is at risk of malaria, with the highest prevalence reported in Gambella (6%) and Benishangul-Gumuz (3%) regions. Within these regions are large agricultural developments with high numbers of seasonal migrant workers. The migrant workers are believed to be at increased risk for malaria infection due to their poor living conditions and outdoor activities, but there is little information on their specific behaviors and health risks. This study was conducted to address this gap. Methods: Quantitative observations were conducted from September to December 2017 in the Benishangul-Gumuz Region. The nightly routines of mobile migrant workers were observed every month for four consecutive months. The study team collected quantitative data including nocturnal behavioral observations of worker living conditions, malaria prevention efforts, and work activities and surveys of worker representatives. Qualitative data was collected from migrant workers, farm managers and local health providers using focus group discussions and semi-structured interviews. Results: Migrant farmers arrived in the study area during the peak malaria transmission season and the workers in focus groups reported repeated cases of malaria during their stay on the farms. Overall, less than a quarter of the migrant workers were sleeping under a mosquito net by midnight in all four observation months. Some work activities also took place outdoors at night. The study additionally found a lack of access to malaria prevention and treatment at the farms and challenges in utilizing local public health facilities. Conclusions: There is a need to better address malaria prevention and treatment needs among migrant workers in Ethiopia through outreach from existing healthcare infrastructure and within the farms themselves. This will help prevent malaria transmission both within this population and prevent transmission of malaria back to home communities in lower burden areas in Ethiopia.
Prevalence of IGFBP3, NOS3 and TCF7L2 Polymorphisms and Their Association With Hypertension: A Population-Based Study With Brazilian Women of African Descent
Authors: Lira Abel , Vasconcelos Nancy , Santos Tamara , Duarte Luisa , Assunção Monica , Marques Carolinne , Ferreira Haroldo 
Published: December 2020

Abstract
Background: African ancestry seems to be a risk factor for hypertension; however, few genetic studies have addressed this issue. This study aimed to investigate the prevalence of polymorphisms NOS3; rs1799983, IGFBP3; rs11977526 and TCF7L2; rs7903146 in Brazilian women of African descent and their association with hypertension.Methods: This is a cross-sectional study with a sample of 1021 women (19–59 years old) from the quilombola communities of Alagoas (Brazil). Demographic, socioeconomic, lifestyle, anthropometric, biochemical, and blood pressure data were collected. DNA was extracted from mucosa epithelial cells of the participants’ cheek. Genotyping was performed by PCR allelic discrimination. Prevalence ratio (PR) was the measure of association, calculated by Poisson regression, with a hierarchical selection of variables.Results: The prevalences of the less frequent genotypes were 26.5% TT genotype of NOS3; rs1799983, 16.7% AA genotype of IGFBP3; rs11977526, and 18.3% TT genotype of TCF7L2; rs7903146. For these conditions, the prevalence of hypertension and PR (adjusted) relatively to the ancestral genotype were, respectively: 52.0% vs 24.5% (PR=1.54; p<0.001), 62.0% vs 24.1% (PR=1.59; p<0.001), and 38.9% vs 27.9% (PR=0.86; p=0.166). Associations with hypertension were statistically significant, except for the TCF7L2; rs7903146 polymorphism, after adjusted analysis. Conclusions: Brazilian Afro-descendant women with the TT genotype for the NOS3 gene and the AA genotype for the IGFBP3 gene are more susceptible to hypertension. The understanding of underlying mechanisms involving the pathogenesis of hypertension can motivate research for the development of new therapeutic targets related to nitric oxide metabolism and the management of oxidative stress.
Sclerosing Angiomatoid Nodular Transformation of the Spleen, a Rare Cause for Laparoscopic Splenectomy: a Case Report and Literature Review
Authors: Yang Jianyang , Zhang Yue , Peng Gongze , Wu Tianchong 
Published: December 2020

Abstract
BACKGROUND: Sclerosing angiomatoid nodular transformation of the spleen is one kind of exceedingly rare benign lesions originated from spleen. The incidence and pathogen remain unclear partially due to its rarity and short history. Consequently, preoperative diagnosis become extremely perplex. Splenectomy is a predominated therapy approach as well as diagnosis method for sclerosing angiomatoid nodular transformation of the spleen. We reported a case underwent computed tomography scan, magnetic resonance imaging and ultrasonic scan preoperatively. Examinations conclusion highly suspected sclerosing angiomatoid nodular transformation of the spleen and was confirmed by pathology after laparoscopic splenectomy. We herein reviewed some literatures on imaging characters of to reveal the possibility of preoperative diagnosis when clinicians encounter and investigated whether laparoscopic splenectomy is an appropriate treatment.CASE PRESENTATION: A 50-year-old female was found with a low dense mass in the spleen by abdominal computed tomography incidentally without any positive symptom. Further enhanced computed tomography scan revealed the lesion with asynchronous enhancement and magnetic resonance imaging showed radio-like rift missing from central. Ultrasonic scan imaging presented hypoechoic gap in the center, pretty similar to magnetic resonance imaging. These radiology imaging features deduced to Sclerosing angiomatoid nodular transformation of the spleen. Laparoscopic splenectomy was performed successfully by our team and histopathological findings convinced the preoperative diagnosis. Gross inspection was coincident to the performance of magnetic resonance imaging.CONCLUSION: By comprehending imaging character profoundly, sclerosing angiomatoid nodular transformation of the spleen can be a differential diagnosis preoperatively when encounter lesion of spleen. We believe that laparoscopic splenectomy is a reliable and effective therapy option for such rare benign lesion of spleen without risk of recurrence.
The Impact of Resection Margin and Microscopic Vascular Invasion for Patients with HBV-related Intrahepatic Cholangiocarcinoma
Authors: Lu Wen-Feng , Chen Pei-Qin , Yan Kai , Wu Ye-Chen , Liang Lei , Yuan Jian-Yong , Fu Yong , Zhang Hai-Bin 
Published: December 2020

Abstract
Background and Aim: The resection margin (RM) status and microscopic vascular invasion (MVI) are known prognostic factors for intrahepatic cholangiocarcinoma (ICC). An enhanced understanding of their impact on long-term prognosis is required to improve oncological outcomes.Methods: We reviewed data on 711 consecutive patients who underwent curative liver resection for hepatitis B virus–related ICC. The different impact of the RM status (narrow, <1 cm, or wide, ≥ 1 cm) and MVI (positive, +, or negative, -) on overall survival (OS) and recurrence-free survival (RFS) were analyzed. Results: The 1-, 3-, and 5-year OS rates were 67.6%, 42.5% and 33.2% in wide RM & & MVI (-), 58.0%, 36.1% and 26.5% in narrow RM & MVI (-), 51.0%, 27.0% and 24.3% in wide RM & MVI (+), and 39.0%, 20.4% and 14.3% in narrow RM & MVI (+) (p < 0.001).The 1-, 3-, and 5-year RFS rates were 60.0%, 40.2% and 28.7% in wide RM & MVI (-), 45.2%, 34.3% and 24.2% in narrow RM & MVI (-), 40.0%, 18.5% and 12.3% in wide RM & MVI (+), and 28.2%, 11.5% and 9.8% in narrow RM & MVI (+) (p < 0.001). Multivariate analysis showed that RM & MVI were independent risk factors for the OS and RFS. Conclusions: Combined analysis of RM and MVI can better stratify the risks of postoperative death and recurrence in patients with HBV-related ICC, which may help subsequent adjuvant therapy and follow-up.
Combination role of DAPK Methylation in Urinary Sediment and B Ultrasound in Evaluating Follow-Up of Urinary Bladder Cancer
Authors: Jiang Fuquan , Li Changfeng , Han Jiansong , Wang Linlin 
Published: December 2020

Abstract
Background: Urinary bladder cancer (UBC) is a highly prevalent disease. This paper aims to explore the combination role of DAPK methylation in urinary sediment and B ultrasound in diagnosing recurrent UBC. Patients and methods: A total of 1021 cases of primary UBC undergone electrocision of bladder tumor through urethra were included were subjected to follow up. B ultrasound, DAPK methylation in urinary sediment, examination of exfoliated cells in urine and cystoscopy were performed.The data were subjected to chi-square and Kappa test. ROC was drawn to evaluate the diagnostic role in recurrent UBC.Results: Among the 1021 patients, 115 patients were recurrent by cystoscopy and biopsy two years, and failed to complete the follow up, thus the effective number of was 906. The cystoscopy results were consistent with that of B ultrasound (Kappa = 0.785, P < 0.05), with that of DAPK methylation in urinary sediment and combination of B ultrasound with DAPK methylation (Kappa = 0.517, P < 0.05, Kappa = 0.593, P < 0.05). The area under curve of combination of B ultrasound with DAPK methylation was 0.922 (sensitivity, 92.86%; specificity, 91.63%; Youden index, 0.845) with negative prediction value of 99.4% which suggested that the recurrent risk would be low in case negative results were obtained.Conclusion: Combination of DAPK methylation with B ultrasound has high performance in diagnosing recurrent UBC.
A Case-Control Study on the Relationship Between Cholecystectomy and Cholangiocarcinoma in China
Authors: Zhu Donglie , Fu Hang , Yang Zelong , Jiang Mingzuo , Ren Yanjie , Zheng Shi , Chen Yong 
Published: December 2020

Abstract
Aims: The present study aimed to explore the correlation between cholecystectomy and cholangiocarcinoma, and to provide preliminary clinical basis for precise cholecystectomy in China.Methods: We conducted a retrospective analysis of 9744 patients with cholangiocarcinoma, colon cancer, pancreatic cancer, femoral fracture, and hepatic hemangioma diagnosed in Xijing hospital from August 2008 to August 2018. They were divided into three groups: case group (1749 cases of cholangiocarcinoma), positive control group (3137 cases of colon cancer and 1950 cases of pancreatic cancer), negative control group (1794 cases of femoral fracture and 1114 cases of hepatic hemangioma). We collected the general information (gender, age), past medical history, cholecystectomy history from the patients, and these data were analyzed by chi-square test and logistic regression analysis. Results: The cholecystectomy rate of the case group was significantly higher than that of the positive control group and the negative control group by chi-square test (p<0.025). The cholecystectomy rate and the history of cholecystolithiasis were analyzed by logistic multivariate regression analysis. The OR values of cholecystectomy rate were 1.553 (95%CI: 1.311-1.840) and 3.181 (95%CI: 2.561-3.951), respectively, and the difference was statistically significant (p<0.000). The OR values of the history of cholecystolithiasis were 2.460 (95%CI: 2.093-2.890) and 5.426 (95%CI: 4.325-6.809), respectively, and the difference was statistically significant (p<0.000). In case group, the difference between cholecystectomy and cholecystolithiasis was statistically significant (p<0.000) by chi-square test. Conclusions: In conclusion, cholecystectomy is one of the risk factors of cholangiocarcinoma and the patients who undergo cholecystectomy have a higher risk of cholangiocarcinoma than the control groups. Cholecystectomy should be conducted with caution and the precise surgical treatment of gallbladder diseases is advocated.
Phase II randomized controlled trial to evaluate the efficacy and safety of HeberFERON versus Heberon alpha R in symptomatic or asymptomatic patients infected with the SARS-CoV-2 (Study ESPERANZA/HOPE).
Authors: Iraldo Bello-Rivero , Hernandez-Bernal Francisco , Nodarse-Cuni Hugo , Duncan-Roberts Yaquelin , Suarez Claudia Martínez , Campa-Legrá Ivan , Esquivel-Moy Idelsis , Muzio-Gonzalez Verena , Guillen-Nieto Gerardo 
Published: December 2020

Abstract
Background: As the outbreak of COVID-19 has accelerated, an urgent need for finding strategies to combat the virus is growing. Results from in vitro studies suggest that a combination of IFN type I and Type II may be effective against SARS-CoV. The aim of this study is to investigate the efficacy of treatment with a recombinant IFN alpha 2b and gamma, provided with standard protocol (Kaletra (lopinavir-ritonavir 200/50 mg; 200/100 mg every 12 hour for 30 days; Chloroquine (250 mg) every 12 hours for 10 days) for COVID-19 patients, compared to standard protocol (IFN alpha 2b/Kaletra/Chloroquine) for COVID-19 hospitalized patients, positive diagnosed for SARS-Cov-2. Methods: Hospitalized adult patients with qPCR confirmed SARS-Cov-2 will be enrolled in this open-labeled, single center, prospective, randomized and controlled clinical trial. One hundred and twenty eligible patients with confirmed SARS-CoV-2 positivity by qPCR amplification in oropharyngeal/nasopharyngeal swab samples will be enrolled at “Luis Diaz Soto” Hospital, Havana, Cuba. The primary outcomes are the time to 2019-nCoV RNA negativity in patients and the time until progression to severe COVID-19. Discussion: This will be the first randomized controlled trial of a potential treatment for SARC-Cov-2 using the combinations of IFNs. Trial registration: The study is sponsored by Center for Genetic and Biotechnology and Ministry of Health of Cuba and was duly registered April 2020 at http://registroclinico.sld.cu/en/trials/RPCEC00000307-En. Enrolment for this study began in April 11, 2020, and has enrolled one hundred patients as of May-26-2020.
Determinants of Perinatal birth Asphyxia among Newborns in Ethiopia: A Systematic Review and Meta-analysis of Observational Studies Protocol
Authors: Woday Abay , Dessalegn Muluken , Birara Setognal , Urmale Kusse , Biset Gebeyaw , Eshetie Sisay , Alemayehu Mekuriyaw 
Published: December 2020

Abstract
Background: Birth asphyxia among newborns accounted for nearly fifty percent of neonatal mortality in sub-Saharan African countries. This scenario has been worst in Ethiopia where every two out of three deaths attributed to birth asphyxia among these babies. Moreover, studies conducted in Ethiopia are highly variable and inconclusive to estimate the pooled prevalence and risk factors of birth asphyxia. Objective: This study aims to analyses collectively and systematically the prevalence of birth asphyxia and associated factors among newborns in Ethiopia.Methods: The protocol for this review is registered at PROSPERO with registration number CRD42020158224. A comprehensive online databases (PubMed, HINARI, Scopus, EMBASE, Science direct, and Cochrane library database), Google Scholar, African Journals online, other gray and online repository accessed studies will be searched using different search engines. In addition, maternity & infant care databases uploaded at Ethiopian Health Development Journal and Ethiopian Journal of Health Sciences will be searched until June 30, 2020. Newcastle-Ottawa Quality Assessment Scale (NOS) will be used for critical appraisal of studies.. Three reviewers will screen all retrieved articles, conduct data extraction, and then critically appraise all identified studies. All identified observational studies reporting the prevalence of birth asphyxia and associated factors among neonates in Ethiopia will be considered. The analysis of data will be done using STATA 11.0 statistical software. We will demonstrate pooled estimates and determinants of birth asphyxia with effect size and 95% confidence interval. Heterogeneity among the included studies will be assessed through the Cochrane Q-test statistics and I2 test. Publication bias will be checked using funnel plot and egger’s test. Finally, statistical significance level will be declared at a p-value of less than 0.05. Discussion: the result from this systematic review will inform and guide health policy planners to invest limited resources on maternal and neonatal health. Furthermore, it will be a stimulus for future cumulative meta-analysis researchers in developing nations.
Predicting pathological complete response (pCR) after stereotactic ablative radiation therapy (SABR) of lung cancer using quantitative dynamic [18F]FDG PET and CT perfusion: A prospective exploratory clinical study
Authors: Yang Dae-Myoung , Palma David A. , Kwan Keith , Louie Alexander V. , Malthaner Richard , Fortin Dalilah , Rodrigues George B. , Yaremko Brian P. , Laba Joanna , Gaede Stewart , Warner Andrew , Inculet Richard , Lee Ting-Yim 
Published: December 2020

Abstract
Background: Stereotactic ablative radiation therapy (SABR) is effective in treating inoperable stage I non-small cell lung cancer (NSCLC), but imaging assessment of response after SABR is difficult. This prospective study aimed to develop a predictive model for true pathologic complete response (pCR) to SABR using imaging-based biomarkers from dynamic [18F]FDG-PET and CT Perfusion (CTP).Methods: Twenty-six patients with early-stage NSCLC treated with SABR followed by surgical resection were included, as a pre-specified secondary analysis of a larger study. Dynamic [18F]FDG-PET provided maximum and mean standardized uptake value (SUV) and kinetic parameters estimated using a previously developed flow-modified two-tissue compartment model while CTP measured blood flow, blood volume and vessel permeability surface product. Using recursive partitioning analysis (RPA), the imaging-based biomarkers for predicting pCR were assessed and compared to current RECIST (Response Evaluation Criteria in Solid Tumours version 1.1) and PERCIST (PET Response Criteria in Solid Tumours version 1.0) criteria.Results: RPA identified three patient groups based on tumour blood volume before SABR (BVpre-SABR) and change in SUV­max (ΔSUVmax). The highest true pCR rate of 92% was observed in the group with BVpre-SABR < 9.3 mL/100g and ΔSUVmax < -48.9% after SABR while the worst was observed in the group with BVpre-SABR ≥ 9.3 (0%). A logistic regression model based on RPA risk groups showed excellent pCR prediction (Concordance: 0.92; P=0.03). RECIST and PERCIST showed poor pCR prediction (Concordance: 0.54 and 0.58, respectively).Conclusions: In this study, we developed a predictive model based on dynamic [18F]FDG-PET and CT Perfusion imaging that was significantly better than RECIST and PERCIST criteria to predict pCR of NSCLC to SABR. This model warrants validation with larger sample size studies.Trial registration: MISSILE-NSCLC, NCT02136355 (ClinicalTrials.gov). Registered May 8, 2014, https://clinicaltrials.gov/ct2/show/NCT02136355