bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vibrodiagnostic operator jaw skidder in the process of lifting (lowering) of the tree with an arrow.
Authors: Василевский М.Р. , Александров В.А. 
Published: September 2020

Рассмотрена вибронагруженность оператора трелевочного трактора в режиме подъема дерева стрелой. Исследование проведено на математической модели биодинамической системы «оператор – трелевочный трактор – дерево». Математическое описание составлено в форме уравнения Лагранжа II рода. Модель оператора – двухмассовая. В процессе исследования варьировалось ускорение разгона стрелы манипулятора в диапазоне 0,1–0,6 м/с2. Расчеты выполнены с исходными данными применительно к трелевочному трактору ТБ-1М. Предложенная математическая модель позволяет определять вибрационное воздействие на организм оператора трелевочного трактора на стадии разработки конструкторской документации.
The article describes vibrodiagnostic operator skidder in the mode of lifting the tree by an arrow. The study was conducted on a mathematical model of the biodynamic system "operator – skidder – wood". The mathematical description is in the form of Lagrange's equations of the 2nd kind. Model operator – dual-mass. During the study varied the acceleration of the acceleration arrows of the manipulator in the range of 0.1 to 0.6 m/s2. The calculations are performed with the original data in relation to the skidding tractor TB-1M. The proposed mathematical model allows to determine vibration effects on the body of the operator of the skidder at the stage of developing design documentation.
Cyberbullying Phenomenon of High School Students: An Exploratory Study in West Kalimantan, Indonesia
Authors: Setiawan William Vincent , Fitrisna Vernawati Eva , Michellianouva Fairuz , Mayliza Celly Septine 
Published: September 2020

Cyberbullying became a common occurrence among teenagers in the world today. The aim of research was to explore the cyberbullying experience of high school students in West Kalimantan. The research was conducted to identify internet usage and online activities that led to cyberbullying victimization. The methods used a questionnaire collected during June 2019 from 50 students (25 males and 25 females) graded 10 to 12, and used a one-way ANOVA analysis. Significant gender differences were found which indicated that boys were more often involved in cyberbullying both as the perpetrator and the victim. Students with lower academic achievement tend to be online perpetrators than students with better academic performance. The research investigated how cyber oppression impacts both as a perspective of victimization and persecution, discussing the practice of reporting students to parents, school officials and other adults. Parental and teacher supervision as a strategy reduces student involvement in cyberbullying and generates awareness among students. The result implies that schools have an important role in teaching cybersecurity, adding cyberbullying subject in the curriculum, and sharing experiences with students.
Risk Profile, Secure Bond, and Bond Rating in Banking Industry
Authors: Wijayanti Erin , Yuliana Indah 
Published: September 2020

The research aimed to assess the impact of the Risk Profile on the banking industry bond ratings in Indonesia Stock Exchange (IDX) and have a rating for bonds at PT PEFINDO. Sampleswere selected by purposive sampling method. The population were banks listed on the Indonesia Stock Exchange in 2015-2018. The population was 44 banks and 16 banks were selected as samples. The analysis a used descriptive statistics and Partial Least Square (PLS) for testing structural and structural models. The results show that Non-Performing Loan (NPL)and Loan to Deposit Ratio (LDR) directly have a significant direct positive effect on bond ratings, and security directly do not have a significant effect on bond ratings, security strengthen risk relationships credit with a bond rating. However, security weakens the relationship between liquidity risk and the bond rating. The variables indicate that these variables can explain the bond rating of 44,4% while the remaining 55,6% is influenced by other variables not contained in the research model.
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
Authors: Yu Xuan , Chu Zixuan , Li Jian , He Rongrong , Wang Yaya , Cheng Chen 
Published: September 2020

Background:
Many antibiotics have a high potential for interactions with drugs, as a perpetrator
and/or victim, in critically ill patients, and particularly in sepsis patients.

Methods:
The aim of this review is to summarize the pharmacokinetic drug-drug interaction (DDI) of 45 antibiotics
commonly used in sepsis care in China. Literature search was conducted to obtain human pharmacokinetics/
dispositions of the antibiotics, their interactions with drug-metabolizing enzymes or transporters, and their
associated clinical drug interactions. Potential DDI is indicated by a DDI index ≥ 0.1 for inhibition or a treatedcell/
untreated-cell ratio of enzyme activity being ≥ 2 for induction.

Results:
The literature-mined information on human pharmacokinetics of the identified antibiotics and their potential
drug interactions is summarized.

Conclusion:
Antibiotic-perpetrated drug interactions, involving P450 enzyme inhibition, have been reported
for four lipophilic antibacterials (ciprofloxacin, erythromycin, trimethoprim, and trimethoprim-sulfamethoxazole)
and three antifungals (fluconazole, itraconazole, and voriconazole). In addition, seven hydrophilic antibacterials
(ceftriaxone, cefamandole, piperacillin, penicillin G, amikacin, metronidazole, and linezolid) inhibit drug
transporters in vitro. Despite no clinical PK drug interactions with the transporters, caution is advised in the use
of these antibacterials. Eight hydrophilic antibiotics (all β-lactams; meropenem, cefotaxime, cefazolin, piperacillin,
ticarcillin, penicillin G, ampicillin, and flucloxacillin), are potential victims of drug interactions due to
transporter inhibition. Rifampin is reported to perpetrate drug interactions by inducing CYP3A or inhibiting
OATP1B; it is also reported to be a victim of drug interactions, due to the dual inhibition of CYP3A4 and OATP1B
by indinavir. In addition, three antifungals (caspofungin, itraconazole, and voriconazole) are reported to be
victims of drug interactions because of P450 enzyme induction. Reports for other antibiotics acting as victims
in drug interactions are scarce.
Bioactive Principles and Potentiality of Hot Methanolic Extract of the Leaves from Artemisia absinthium L “in vitro Cytotoxicity Against Human MCF-7 Breast Cancer Cells, Antibacterial Study and Wound Healing Activity”
Authors: Sultan Muhammad H. , Zuwaiel Alanazi A. , Moni Sivakumar S. , Alshahrani Saeed , Alqahtani Saad S. , Madkhali Osama , Elmobark Mohamed E. 
Published: September 2020

Background:
Artemisia absinthium L is an ornamental plant widespread in Saudi Arabia.
Traditionally, the plant has been used in the Arabic medicine. But the scientific evidence of the bioactive
compounds and their medicinal value was not yet explored widely.

Objective:
The study was designed to analyse the bioactive principles and medicinal properties of Artemisia
absinthium L, a traditional herb grown in southern part of Saudi Arabia.

Methods:
The bioactive compounds present in Hot Methanolic Extract of the Leaves (HMEL) of Artemisia
absinthium L. was explored by GC-MS analysis. The cytotoxicity effect of HMEL was determined
against MCF-7 breast cancer cells ATCC and human colon cancer cells HCT 116 ATCC by performing
MTT assay. Morphological changes of HMEL treated MCF-7 were observed under a phasecontrast
microscope by staining the cells with neutral red. A Reaction Mixture (RM) of HMEL was prepared
in Milli-Q water and antibacterial susceptibility was performed against both Gram-positive and
Gram-negative bacteria. Furthermore, in vivo wound healing properties of the RM was screened in male
rats and their efficacy was compared with standard povidone iodine cream. Biomarkers such as IL-1β, IL-
6, TNF- α, caspase-9 and caspase-3 levels were determined to qualify the wound healing property.

Results:
Epiyangambin, flavone, octadecanoic acid, 2,3-dihydroxypropyl ester, palmitic acid β -
monoglyceride, á-D-mannofuranoside, camphor, and terpineol were identified as possible compounds
through GC-MS analysis. The HMEL of Artemisia absinthium L was actively inhibiting the proliferation
of breast cancer cells MCF-7 ATCC at the concentration of 80.96 ± 3.94 μg/ml as IC50 value but
failed to inhibit the proliferation against the treated human colon cancer cells HCT 116 cells ATCC.
HMEL of Artemisia absinthium L was showing a moderate spectrum of antibacterial effect against the
screened bacteria. RM showed better wound healing property than standard povidone iodine cream that
modulates cytokine networks and apoptosis markers levels indicated the healing of wound.

Conclusion:
The study suggested that novel anticancer, antibacterial and immune modulatory molecules
can be developed from the leaves of Artemisia absinthium L.
In Silico Docking Studies of Vascular Endothelial Growth Factor-A (VEGFA): Possible Implications in Chronic Myeloid Leukemia (CML) Therapy
Authors: Lakkireddy Samyuktha , Jayaraman Archana , Aula Sangeetha , Kapley Atya , Kutala Vijay Kumar , Jamil Kaiser 
Published: September 2020

Background:
Dysregulated angiogenesis resulting in neovascularization is a critical
event in the expansion and progression of Chronic Myeloid Leukemia (CML), hematopoietic cancer.
Vascular Endothelial Growth Factor- A (VEGFA), an important angiogenesis mediator, has
been a target for treating cancer. Although several anti-VEGFA drugs are available, they are associated
with adverse side effects, promoting the need to identify better drugs that may be less toxic.

Objective:
Our aim was to investigate whether Tyrosine Kinase Inhibitors (TKIs) could be repurposed
for use as VEGFA inhibitors via in silico docking software. We also investigated the potential
of phytochemicals as VEGFA inhibitors.

Methods:
We performed molecular docking using Schrödinger Maestro software suite 2014-3 to
determine the most potent phytochemical and TKI VEGFA antagonists.

Results:
Among the TKIs investigated, Bosutinib had the best binding affinity and may be the
most potent TKI against VEGFA. The order of binding affinities for the top ten docked ligands
was: Ginsenoside Rg3> Bosutinib> Vitamin D> Paclitaxel> Dasatinib> Saponins> Ponatinib>
Squalamine> Imatinib> Nilotinib. We found that Ginsenoside Rg3 had the highest binding affinity
(MMGBSA score= -99.4 kcal/mol, glide Gscore = -9.16 kcal/mol) to VEGFA.

Conclusion:
Our study has shown for the first time the binding poses of these TKIs and phytochemicals
to VEGFA, using computational methods. We propose that the use of the top scoring ligands,
in isolation or a combination of phytochemicals plus TKI, could serve as potent angiogenesis
inhibitors via their binding to and inhibiting VEGFA expression to prevent CML progression.
We have also profiled the ligand binding residues, which may be explored in designing pharmacophores.
Detection and Classification of Gastrointestinal Diseases using Machine Learning
Authors: Naz Javeria , Sharif Muhammad , Yasmin Mussarat , Raza Mudassar , Khan Muhammad Attique 
Published: September 2020

Background:
Traditional endoscopy is an invasive and painful method of examining the
gastrointestinal tract (GIT) not supported by physicians and patients. To handle this issue, video endoscopy
(VE) or wireless capsule endoscopy (WCE) is recommended and utilized for GIT examination.
Furthermore, manual assessment of captured images is not possible for an expert physician
because it’s a time taking task to analyze thousands of images thoroughly. Hence, there comes the
need for a Computer-Aided-Diagnosis (CAD) method to help doctors analyze images. Many researchers
have proposed techniques for automated recognition and classification of abnormality in
captured images.

Methods:
In this article, existing methods for automated classification, segmentation and detection
of several GI diseases are discussed. Paper gives a comprehensive detail about these state-of-theart
methods. Furthermore, literature is divided into several subsections based on preprocessing techniques,
segmentation techniques, handcrafted features based techniques and deep learning based
techniques. Finally, issues, challenges and limitations are also undertaken.

Results:
A comparative analysis of different approaches for the detection and classification of GI
infections.

Conclusion:
This comprehensive review article combines information related to a number of GI
diseases diagnosis methods at one place. This article will facilitate the researchers to develop new
algorithms and approaches for early detection of GI diseases detection with more promising results
as compared to the existing ones of literature.
Recent Patents on Phytoconstituents-based Formulations for the Treatment of Acne Infection: A Review
Authors: Singh Vandana , Verma Ravinder , Kaushik Deepak , Mittal Vineet 
Published: September 2020

Background:
Acne is an infection of the skin that occurs in both men
and women during their lifespan. There are various natural or synthetic products
available in the market to prevent and cure this disease.

Introduction:
The majority of the world population depends on the herbs or natural
resources for the relief of acne disease. These are used to lessen the cost of
treatment and the side effects of synthetic analogs.

Methodology:
We have explored the various authentic web resources to compile information
regarding different patented and marketed herbal formulations for
acne treatment.

Results:
It has been found that most of the herbal formulation for acne include
the plant actives/extracts having the potential activity against the Propionibacterium
acne. The occurrence of this skin disease is also associated with the presence
of free radicals in the body, which also causes the inflammation and redness of
the skin. Further, the study of various patents also revealed that herbs with
anti-oxidant properties have been used in most of the herbal anti-acne formulations.
Moreover, the various patents also give the idea that herbal formulations also
prevent the appearance of pimples on the skin.

Conclusion:
It has been concluded that the herbal anti-acne formulation is not only
used to treat acne but also prevents this disease safely and economically.
Synthesis of 1H-1,2,3-Triazole-Linked Quinoline-Isatin Molecular Hybrids as Anti-Breast Cancer and Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Agents
Authors: Awolade Paul , Cele Nosipho , Ebenezer Oluwakemi , Kerru Nagaraju , Gummidi Lalitha , Gu Liang , Palma Gabriella , Kaur Mandeep , Singh Parvesh 
Published: September 2020

Background:
The persistence of breast cancer as the leading cause of mortality among women, coupled
with drug resistance to tamoxifen, the standard endocrine therapy for the disease, exacts continuous attention.
To this effect, molecular hybridisation offers an attractive route to drugs with improved bioactivity profiles.

Objective:
The primary goal of this study was to examine the potential of 1H-1,2,3-triazole linked quinolineisatin
molecular hybrids as drug candidates against breast cancer and Methicillin-Resistant Staphylococcus
aureus (MRSA) cells.

Methods:
The quinoline-isatin hybrids were synthesised via click chemistry-mediated molecular hybridisation
strategy. Anti-breast cancer activity was determined in 3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetrazolium
bromide (MTT) assay using Estrogen-Responsive (ER+) MCF-7 and MDA-MB-231 (Triple-Negative Breast
Cancer -TNBC) cells, while antimicrobial efficacy was established via the broth dilution method. Also, the
toxicity profile of potent compounds to non-cancerous cells was determined using human embryonic kidney
cells (HEK293) and human Red Blood Cells (hRBCs). In silico techniques were employed to predict the druglike
properties of potent compounds and understand their binding modes with Estrogen Receptor alpha (ERα).

Results:
Compounds 7g-i exhibited the strongest cytotoxicity to MCF-7 cells with IC50 values of 23.54, 23.66,
and 32.50μM, respectively. Interestingly, compound 7h also emerged as the best drug candidate against MDAMB-
231 and MRSA cells with IC50=71.40μM and MIC80=27.34μM, respectively. Structure-activity relationship
analysis revealed that quinoline-2-carbaldehyde and 5,7-disubstituted isatin moieties confer desirable potency.
These compounds showed no significant cytotoxic or haemolytic effects on HEK293 or hRBCs in vitro at their
active concentrations; hence, eliciting their selectivity for cancer cells. In silico studies also presented the drugability
of potent compounds and the likely structural features interacting with amino acid residues at the ligandbinding
domain of ERα.

Conclusion:
These results suggest that the identified 1H-1,2,3-triazole-linked quinoline-isatin hybrids are viable
chemotypes that can be adopted as templates for the development of new anti-breast cancer and anti-MRSA agents.
“Non-Classical” Indication for Provocative Testing of Growth Hormone: A Retrospective Cohort Study in Adult Patients Under Replacement Therapy
Authors: Mancini Antonio , Bruno Carmine , Vergani Edoardo , Brunetti Alessandro , Palmisano Gerardo , Pontecorvi Alfredo 
Published: September 2020

Background:
Adult growth hormone deficiency (GHD) is considered a rare condition.
Current guidelines state that GH provocative test is indicated in patients affected by organic hypothalamic/
pituitary disease or with a history of head injury, irradiation, hemorrhage or hypothalamic
disease with multiple pituitary deficiencies. Nevertheless, the clinical picture related to GHD
may be subtle.

Objective:
We have retrospectively evaluated the indication to GHRH+arginine test in our monocentric
cohort of patients treated with hrGH in order to assess whether other conditions had been
considered as a rationale for provocative testing.

Methods:
Ninety-six patients (51 females and 45 males), aged 19-67 years were included. The
GHRH+arginine test had been performed in 29 patients with organic hypothalamic/pituitary disease
and in 4 patients for Childhood onset-GHD (CoGHD). In other patients, the diagnosis was suspected
for “non classical” reasons in the clinical picture suspected for GHD.

Results:
Classical indications included previously known primary empty sella (n=15), pituitary
surgery (n=14), pituitary cyst (n=1), non-secreting pituitary tumors (n=3) but more than half of the
patients (57.3%) had been studied for “non classical” indications: metabolic syndrome (n=25), asthenia
(n=13), heart failure (n=4), osteoporosis (n=6), unexplained hypoglycaemia (n=1) and infertility
(n=6). The latter represented a significant percentage in the male subgroup under 45 ys.
IGF-1 levels were lower than 50th percentile in 63% of patients. Finally, among non-classical reasons,
organic pituitary disease was discovered in 22 patients.

Conclusions:
Idiopathic GHD may be unrecognized due to its subtle manifestations and that an extended
use of dynamic GH tests may reveal such conditions. A potential field of investigation
could be to identify subsets of patients with clinical conditions caused or worsened by underlying
unrecognized GHD.
Methodological Challenges in Investigating Supracondylar Fractures of the Humerus From a Child’s Viewpoint: Evolution of Study Protocol
Authors: Lim Brittany Tara , Chhina Harpreet , Pike Ian , Brussoni Mariana , Cooper Anthony 
Published: September 2020

BackgroundOutdoor play and risk-taking behaviors, including play at heights, are important to children’s physical, social, and cognitive development. These aspects of play are important to consider when informing prevention policies for serious injuries that commonly occur on play structures. Supracondylar fractures of the humerus (SCH) are the most common type of elbow fractures that result from falls on an outstretched hand among healthy children. Despite being one of the leading causes of admission to the hospital and surgical intervention, the details surrounding the cause of these injuries are often not recorded. Previous research has correlated decreased overall playground safety with higher rates of SCH fractures. Play structure height and the type of undersurface have been identified as potential risk factors for severe injuries, including SCH fractures, in part due to low compliance with safety standards. This paper explores the challenges we encountered designing the study and the resulting insights and methodological modifications we made.ObjectiveThe aim of this paper is to discuss the challenges related specifically to clinical research in pediatrics and strategies developed to conduct a study that prioritizes the engagement and perspective of children and their families.MethodsTo explore the link between the severity of SCH fractures and children’s behavioral, environmental, and mechanistic factors, we conducted a mixed-methods study.ResultsDuring phase 1 (the original methodology) from April 2017 to July 2018, there were 58 eligible study participants and 17 were recruited. For phase 2 (the revised methodology) between October 2018 and October 2019, there were 116 eligible participants and 47 were recruited.ConclusionsThe changes in methodology made following the first phase of data collection were effective in our ability to recruit participants. By identifying and addressing challenges pertaining to recruitment and resource limitations, we were able to collect data in a concise manner while not compromising the quality of the data and make for an easily adoptable methodology for other sites interested in participating in the study. We hope that future studies that plan to employ a similar methodology can gain insight through the methodological challenges we have encountered and the way we adapted the methodology to build a more pragmatic approach.International Registered Report Identifier (IRRID)DERR1-10.2196/21816
Application of TRMM in the Hydrological Analysis of Upper Bengawan Solo River Basin
Authors: Senjaya Theo , Yudianto Doddi , Yuebo Xie , Adidarma Wanny K. 
Published: September 2020

Rainfall is a major water resource with a significant role in terms of growth, environment concerns, and sustainability. Several human activities demand adequate water supply for drinking, agriculture, domestic, and commercial consumption. The accuracy of any hydrologic study depends heavily on the availability of good-quality precipitation estimates. Most countries are unable to provide sufficient climatic data, including rainfall and observed discharge statistics. This scarcity is a huge obstacle in conducting thorough hydrologic studies over a certain period. For instance, Indonesia, as an archipelagic country, has long been faced with data availability problems. For this reason, Tropical Rainfall Measuring Mission (TRMM), which was developed by NASA, became an alternative solution to rainfall data limitations. However, to be applied in hydrologic investigations, TRMM data require proper estimation and adjustment. The aim of this study was to evaluate the quality of TRMM rainfall data and its application in determining design flood and water availability. Dividing the data into several groups based on its magnitude and multiplying each unit with a correction coefficient are parts of the modification process. Subsequently, objective functions, including false alarm ratio (FAR), probability of detection (POD), and root mean square error (RMSE) were also applied. Rainfall-runoff modeling and design storm analysis at Delingan dam were used to study the TRMM correction performance. Based on the analysis, corrected TRMM showed considerable findings compared to ground station data. Model calibration and verification using corrected TRMM data provide satisfactory model parameters compared to ground station derivatives. The results also disclosed a closer fit of the corrected TRMM to catchment response translated from derived rainfall-runoff model parameters to ground station compared to control. Furthermore, design storm calculated from corrected TRMM reflects an improvement compared to uncorrected TRMM data.