bluuebunny/crossref_metadata_2025_split huggingface dataset:
The MAGIC Experiment: A Combined Seismic and Magnetotelluric Deployment to Investigate the Structure, Dynamics, and Evolution of the Central Appalachians
Authors: Long Maureen D. , Benoit Margaret H. , Evans Rob L. , Aragon John C. , Elsenbeck James 
Published: July 2020

Abstract
The eastern margin of North America has undergone multiple episodes of orogenesis and rifting, yielding the surface geology and topography visible today. It is poorly known how the crust and mantle lithosphere have responded to these tectonic forces, and how geologic units preserved at the surface related to deeper structures. The eastern North American margin has undergone significant postrift evolution since the breakup of Pangea, as evidenced by the presence of young (Eocene) volcanic rocks in western Virginia and eastern West Virginia and by the apparently recent rejuvenation of Appalachian topography. The drivers of this postrift evolution, and the precise mechanisms through which relatively recent processes have modified the structure of the margin, remain poorly understood. The Mid-Atlantic Geophysical Integrative Collaboration (MAGIC) experiment, part of the EarthScope USArray Flexible Array, consisted of collocated, dense, linear arrays of broadband seismic and magnetotelluric (MT) stations (25–28 instruments of each type) across the central Appalachian Mountains, through the U.S. states of Virginia, West Virginia, and Ohio. The goals of the MAGIC deployment were to characterize the seismic and electrical conductivity structure of the crust and upper mantle beneath the central Appalachians using natural-source seismic and MT imaging methods. The MAGIC stations operated between 2013 and 2016, and the data are publicly available via the Incorporated Research Institutions for Seismology Data Management Center.
Comportamiento obstétrico de mujeres menores de 20 años comparado con el de mujeres de otras edades
Authors: Botero Uribe Jaime , Tuberquia C. Julio César , Huerta Marcelo 
Published: July 2020

Se presenta un estudio sobre el comportamiento obstétrico de mujeres menores de 20 años y se compara con el de mujeresde 20 a 34 años y con el de 35 y más, basado en el análisis de 7.897 historias clínicas de pacientes atendidas en el Hospital Universitario San Vicente de Paúl de Medellín, Colombia, en un período de 25 meses, entre Abril de 1969 y Abril de 1971.
Contenido de glucosa en el líquido amniótico de embarazos normales
Authors: Sánchez Torres Fernando , Onatra Herrera William 
Published: July 2020

Se estudió el contenido de glucosa por el método de Folin y Wu en 79 muestras de liquido amniótico obtenido por amniocentesis transabdominal, en embarazos normales comprendidos entre las semanas 15 y 42.El promedio establecido fue de 40,48 mg.%, comprobándose un descenso significativo entre más avanzado estaba el embarazo.
Espectrofotometría del líquido amniótico. Titulación de bilirrubinas y proteínas totales
Authors: Velasco Chiriboga Alvaro , Rodríguez Soto Arturo , Suárez Manuel 
Published: July 2020

Las bases experimentales para demostrar que la bilirrubina proviene de la destrucción de los hematíes, fueron establecidas por Virchow y comprobadas posteriormente por Aschoff y Mann (7), quedando así́ abierto un amplio campo de investigación en la fisiología y patología del manejo de estos pigmentos por el organismo humano.
Diabetes Caused by Statin Use: A Review
Authors: Zulfiana Risa , Medina Farah , Suharjono Suharjono 
Published: July 2020

<p>Statins are generally recognised as being safe and well tolerated cholesterol-lowering drug and have been successfully used for prevention of primary and secondary cardiovascular disease. However, Some researchers have reported diabetes development in patients taking statins. A number of meta-analyses conducted in recent years have proved that the association is real even though its causality have not been fully elucidated. Various pathophysiological mechanisms that could explain the increased risk of diabetes in patients treated with statin have been described. These are mainly responsible for impairment of β -cell insulin secretion and alteration of intercellular signaling through depletion of important downstream products. This review aims to examine the relationship between statin treatment and the presence of diabetes. Previous clinical reviews of the evidence and pathophysiological mechanisms involved may also be explained. Furthermore, many studies have concluded that Pitavastatin and pravastatinom do not affect glycemic control and may be a beneficial treatment option in patients with, or at risk for, type 2 diabetes.</p>
Association between Serum Vitamin D and Diabetic Retinopathy in Portuguese Patients with Type 1 Diabetes
Authors: Lopes Miguel , Laiginhas Rita , Madeira Carolina , Neves João Sérgio , Barbosa Margarida , Rosas Vitor , Carvalho Davide , Falcão-Reis Fernando , Falcão Manuel 
Published: July 2020

Introduction: Recently, vitamin D has gained importance as a diabetes risk modifier. Our aim was to assess the association between serum vitamin D levels and the prevalence of diabetic retinopathy in patients with type 1 diabetes.Material and Methods: Retrospective review of a population of patients with type 1 diabetes followed in a Portuguese tertiary center. Patients were included if they had an ophthalmological evaluation and a serum 25-hydroxyvitamin D level determination within the same year. Logistic regression analysis was used to adjust for possible confounders.Results: We included 182 patients (47% male), and 57% (n = 103) had signs of diabetic retinopathy. We found a significant association between lower circulating levels of 25-hydroxyvitamin D levels and a greater prevalence of diabetic retinopathy after adjusting for confounders (duration of diabetes, estimated glomerular filtration rate, age, sex, metabolic control, season, dyslipidemia and hypertension) (OR = 0.94; 95% CI 0.90 - 0.99, p = 0.023). Longer duration of diabetes and worse metabolic control also remained associated with diabetic retinopathy in the multivariate analysis (OR = 1.20; 95% CI 1.13 - 1.27, p < 0.001 and OR = 4.13; 95% CI 1.34 - 12.7, p = 0.013, respectively).Conclusion: Lower levels of vitamin D were associated with an increased prevalence of diabetic retinopathy in patients with type 1 diabetes, after adjusting for possible confounders. Future controlled studies may elucidate the molecular routes for this association as well as the role of supplementation in the prevention of diabetes microvascular complications.
Práticas educativas em museus da educação: algumas experiências
Authors: Muller Christine 
Published: July 2020

Este trabalho faz parte da tese de doutorado defendida pela autora em junho de 2019. Aborda práticas educativas em museus da educação e pedagógicos, com foco nas interações que ocorrem no espaço do museu. Dentro deste enfoque foi formulado o seguinte problema: as propostas interativas das exposições museológicas têm realmente permitido o diálogo com as experiências do público? Segundo Wagensberg (2006), há três formas de promover a interatividade nas exposições. São elas a interatividade manual” (hands on), a interatividade mental (minds on) e a a interatividade cultural (heart on). A pesquisa que se articula ao projeto “Preservação do Patrimônio Histórico Educativo”, sob a coordenação da Profa. Dra. Maria Cristina Menezes tem como objetivo apresentar e discutir algumas práticas educativas que estão sendo desenvolvidas no Memorial laboratório de estudos e pesquisas escolares da E.E. Carlos Gomes - Campinas-SP. Uma das escolas em que o projeto mencionado desenvolve pesquisas. Para essa investigação foram empregadas as pesquisas relacionadas à educação em museus articuladas a um referencial metodológico no qual se busca, na bibliografia sobre museologia crítica e educação patrimonial. Com o objetivo de justificar a metodologia que norteou o presente trabalho foi implementada uma proposta/vivência, junto às 3 turmas de 6º ano, da Escola Estadual Carlos Gomes, Campinas-SP, denominada Sensibilização e Visita ao Memorial da Escola Estadual Carlos Gomes.
O programa nuclear iraniano e o regime de não-proliferação: dilemas para o futuro
Authors: Gontijo Raquel , Januário Luiza Elena 
Published: July 2020

O programa nuclear iraniano causa receios e inquietações há tempos, existindo suspeitas de que o país almeje a utilização da energia nuclear para fins militares, tornando-se uma potência nuclear ilegítima. Décadas de sanções e iniciativas de negociação não têm alcançado resultados satisfatórios. O presente artigo visa analisar o atual quadro da questão nuclear iraniana, argumentando que reflete controvérsias e dificuldades intrínsecas do regime de não proliferação nuclear.
Team Approach: Management of Brachial Plexus Birth Injury
Authors: Schmieg Sandra , Nguyen Jie C. , Pehnke Meagan , Yum Sabrina W. , Shah Apurva S. 
Published: July 2020

» Brachial plexus birth injury is an upper-extremity paralysis that occurs from a traction injury to the brachial plexus during birth. Approximately 10% to 30% of children with a brachial plexus birth injury have residual neurologic deficits with associated impact on upper-limb function.» Management of brachial plexus birth injuries with a multidisciplinary team allows optimization of functional recovery while avoiding unnecessary intervention. Early occupational therapy should be initiated with a focus on range of motion and motor learning.» The need for microsurgical reconstruction of the brachial plexus can be predicted based on early physical examination findings, and reconstruction is generally performed at 3 to 9 months of age.» The majority of children with residual neurologic deficits develop associated glenohumeral dysplasia. These children may require secondary procedures, including botulinum toxin injection, subscapularis and pectoralis lengthening, shoulder capsular release, shoulder tendon transfer, and humeral osteotomy.
Rasgos funcionales de plantas leñosas en áreas verdes de Bogotá, Colombia
Authors: Rodríguez-Alarcón Slendy Julieth , Pinzón-Pérez Luisa , López Cruz José , Cabrera Amaya Diego 
Published: July 2020

Los rasgos funcionales de plantas pueden utilizarse para examinar estrategias en el uso de recursos, y proporcionan información sobre respuestas de las especies a condiciones ambientales y su incidencia en el funcionamiento del ecosistema. Debido a la gran variedad de plantas, las bases de datos de rasgos aún presentan vacíos de información. Proporcionamos una base de datos de rasgos funcionales de plantas maderables nativas y exóticas de áreas verdes de Bogotá, Colombia. Se incluyen cinco rasgos funcionales (densidad de la madera, altura máxima, área foliar, área foliar específica y contenido foliar de materia seca) de 508 individuos pertenecientes a 101 especies, distribuidas en 44 familias taxonómicas. La medición de rasgos funcionales se realizó en las especies arbóreas y arbustivas más abundantes determinadas de la base de datos del Arbolado Urbano de Bogotá (SIGAU), y del muestreo de vegetación en microcuencas rurales y en la Reserva Forestal Protectora Bosque Oriental de Bogotá. Este muestreo utilizó parcelas de 50 m2 (arbustales) y 100 m2 (bosques nativos y plantaciones forestales). La base de datos presentada incluye 3556 registros de rasgos de 68 especies nativas y 33 exóticas, información que permitirá comparar resultados de otros estudios y optimizar recursos, por su facilidad de acceso; también complementa bases nacionales y mundiales de rasgos funcionales, herramientas importantes en estudios ecológicos.
Aplikasi Ekstrak Daun Zaitun (Olea Europaea L.) dalam Pengemasan Vakum untuk Mencegah Pencoklatan pada Buah Salak
Authors: Al-Baarri Ahmad Nimatullah , Rizqiati Heni , Zulkharisma Mochammad Dicky , Legowo Anang Mohamad , Mawarid Ailsa Afra , Pangestika Widia , Hadipernata Mulyana , Broto Wisnu 
Published: July 2020

<p>Pencoklatan pada buah salak disebabkan oleh aktivitas enzim polifenol oksidase (PPO) yang bereaksi dengan oksigen menghasilkan o-kuinon yang membuat warna menjadi coklat, oleh karena itu adanya penghambatan kerja enzim PPO, dapat mencegah terjadinya warna coklat pada buah. Tujuan penelitian ini adalah untuk mengetahui pengaruh aplikasi rebusan daun zaitun dalam rangka untuk mencegah terjadinya warna coklat yang dianalisis berdasarkan pada parameter penyertanya, yaitu warna, pH, gula terlarut, dan konduktivitas pada buah salak. Daun zaitun kering dilarutkan dalam air yang kemudian dimasukkan ke dalam wadah plastik berisi potongan salak. Sebagai kontrol, potongan salak disimpan dengan dan tanpa aquades. Pengamatan terhadap salak dilakukan sebanyak 7 kali selama 9 hari pada suhu kamar. Berdasarkan parameter warna, perlakuan zaitun mampu menahan warna lebih baik sebesar 28,17% pada nilai L*, 53,68% pada nilai a*, dan 27,19% pada nilai b*. pH salak dengan perlakuan zaitun dapat dijaga sehingga kenaikannya hanya sebesar 3,8% dan nilai konduktivitas hanya meningkat sebesar 18,5%. Pada parameter gula terlarut, perlakuan dengan zaitun dapat mempertahankan perubahannya sampai sebesar 4,29%. Kesimpulannya, perlakuan penambahan daun zaitun lebih baik dalam mempertahankan warna, derajat keasaman, konduktivitas dan gula terlarut pada buah salak daripada perlakuan dengan dan tanpa penambahan aquades.</p><p> </p><p><strong>Application of Olive Leaves Extract (Olea europaea L.) in Vacuum Packaging to Prevent Browning on Salacca Fruit</strong></p><p>Browning occurs due to the activity of the polyphenol oxidase (PPO) enzyme that reacts with oxygen to produce O-quinone which causes the forming of brown color on fruit. One of the methods in preventing browning is the addition of antioxidant compounds from olive leaf. The purpose of this study was to determine the effect of addition olive leaf extract in the properties of color, pH, dissolved sugar, and conductivity in snake fruit with storage at room temperature. The snake fruit was cut into 1 g in size then was set with olive leaves extract in vacuum plastic container. The treatment was repeated 7 times and the storage was conducted for 9 days in room temperature. The contact with and without aquadest was also observed as control. The results indicated that the olive leaf treatment was able to hinder color changes by 28.17% in L*, while in a* and b* could be suppressed by 53.68 and 27.19%, respectively. On the pH, the increase could be suppressed by 3.8%, while on the conductivity and dissolved sugar could be inhibited by 18.5 and 4.29%, respectively. As conclusions, the addition of olive leaf was provided better effect to maintain the color, pH, conductivity, and dissolved sugar in snake fruit than those of with and without aquadest.</p><p><strong><br /></strong></p>
Los retos en investigación, comunicación y educación de los museos de Lima en el marco de la COVID-19. Una discusión sobre los desafíos del futuro a partir de su situación actual y de las experiencias del MALI y el MUCEN
Authors: Delgado Pacheco Sissy 
Published: July 2020

El 90% de los aproximadamente 60 000 museos que existen en el mundo han cerrado total o parcialmente debido a la COVID-19. En este nuevo contexto uno de los principales retos de los museos es el mantenimiento del compromiso con su público. El estudio busca identificar evidencias que demuestren cuán preparados estaban los museos en la ciudad de Lima para enfrentar un nuevo contexto como la COVID-19 y cuáles son las recomendaciones que podrían seguir en materia de investigación, comunicación y educación.
Para ello, a través de un estudio exploratorio de análisis del discurso se identificó una lista de recomendaciones agrupadas por tres categorías: manejo de colecciones en línea, visitas virtuales y uso de las redes sociales como espacios de aprendizaje. Esta investigación demuestra que los museos que realizaron estrategias relacionadas con las funciones de investigación, comunicación y educación, así como en el uso de tecnologías de información y comunicación, enfrentarán este nuevo contexto con mayores alternativas de distribución de contenidos hacia sus públicos.
Se afirma, entonces, que en este nuevo contexto los museos se convierten en entidades omnipresentes y tienen como reto convertirse en entes vivos, articulados e involucrados con su comunidad digital. Los retos más resaltantes son poner a disposición sus colecciones digitales y acortar las brechas de iniciativas orientadas a la educación. Por último, se identificaron cinco problemas que no permitirán el avance de las recomendaciones señaladas: la falta de estudio de sus públicos, la falta de sostenibilidad financiera, las mínimas estrategias de inclusión, la nueva capacitación de sus colaboradores y la falta de trabajo articulado con otras instituciones.
Common bean resistance to Xanthomonas is associated with upregulation of the salicylic acid pathway and downregulation of photosynthesis.
Authors: Foucher Justine , Ruh Mylène , Préveaux Anne , Carrère Sébastien , Pelletier Sandra , Briand Martial , Serre Rémy-Félix , Jacques Marie-Agnès , Chen Nicolas W.G. 
Published: July 2020

Abstract
Background: Common bacterial blight (CBB) caused by Xanthomonas phaseoli pv. phaseoli and Xanthomonas citri pv. fuscans is one of the major threats to common bean crops (Phaseolus vulgaris L.). Resistance to CBB is particularly complex as 26 quantitative resistance loci to CBB have been described so far. To date, transcriptomic studies after CBB infection have been very scarce and the molecular mechanisms underlying susceptibility or resistance are largely unknown. Results: We sequenced and annotated the genomes of two common bean genotypes being either resistant (BAT93) or susceptible (JaloEEP558) to CBB. Reciprocal BLASTp analysis led to a list of 20,787 homologs between these genotypes and the common bean reference genome (G19833), which provides a solid dataset for further comparative analyses. RNA-Seq after inoculation with X. phaseoli pv. phaseoli showed that the susceptible genotype initiated a more intense and diverse biological response than the resistant genotype. Resistance was linked to upregulation of the salicylic acid pathway and downregulation of photosynthesis and sugar metabolism, while susceptibility was linked to downregulation of resistance genes and upregulation of the ethylene pathway and of genes involved in cell wall modification. Conclusions: This study helps better understanding the mechanisms occurring during the early colonization phase of common bean by Xanthomonas and unveils new actors potentially important for resistance and susceptibility to CBB. We discuss the potential link between the pathways induced during bean colonization and genes induced by transcription activator-like effectors (TALEs), as illustrated in other Xanthomonas pathovars.
Circ_0000190 favors gastric cancer patients potentially via inhibiting miR-1252/PAK3 pathway
Authors: Wang Gui Jun , Yu Tian Yu , Li Yan Rong , Liu Yang Jun , Deng Bei-Bei 
Published: July 2020

Abstract
Background: Gastric cancer is a serious malignant tumor associated with aberrant circular RNAs (circRNAs) expression. In this study, we aim to investigate the role and the underlying mechanism of circ_0000190, a circRNA in gastric cancer.Methods: Circ_0000190 expression in vivo was examined in gastric cancer and adjacent normal tissues by RT-PCR. Circ_0000190 expression in gastric cancer cell lines was detected by FISH and RT-PCR. The role of the circRNA in gastric cancer cells was assessed by the analysis of cell viability, apoptosis, proliferation, cell cycle and migration. The potential effector of circ_0000190 was predicted by computational screen and validated by luciferase reporter assay. Furthermore, Mice model of human gastric cancer: was established to observe the underlying mechanisms of circ_0000190.Results: Circ_0000190 was down-regulated in gastric cancer tissues and cells, with a major location in cytoplasm. Circ_0000190 inhibited gastric cancer cell viability, proliferation and migration, and induced apoptosis and cell cycle arrest by regulating the expression of capase-3, p27 and cyclin D. In addition, the circRNA was validated as a sponge of miR-1252, which directly targeted PAK3. The effects of circ_0000190 on the cellular processes were blocked by miR-1252 mimics, which could be rescued after further overexpression of PAK3.Conclusions: Circ_0000190 suppresses gastric cancer progression potentially via inhibiting miR-1252/PAK3 pathway, employing circ_0000190 might be a promising therapeutic strategy for the treatment of gastric cancer.
Assessment on Awareness Towards Preventive Measures of COVID-19 in Sheka, South Nation Nationalities and Peoples of Region, Southwestern Ethiopia: Community Based Cross-Sectional Study
Authors: Gelaw Assaye Belay , Andargie Solomon Abebaw 
Published: July 2020

Abstract
Background: The coronavirus disease2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and it is the most important public health problem worldwide. A critical element in tackling the COVID-19 crisis is personal behavioral change. However, there is a paucity of evidence that shows peoples ‘on awareness towards COVID-19 pandemic. Thus, this study aimed to assess the awareness level towards COVID-19 in Sheka, South nation nationalities, and peoples of the region (SNNPR), Southwestern Ethiopia.Methods: A community-based cross-sectional study was employed 10th to 21th of April 2020. A total of 419, study participants included in this study. Both univariable and multivariable logistic regression analyses used to identify significant factors of awareness level. Variables with p-value<0.05 were considered significant influences of the awareness.Results: Of all respondents in the study, nearly half(49.4 %) of participants had an awareness of COVID-19.Sex, education level, religion, symptom, and knowing prevention methods were factors significantly associated with an understanding of COVID-19. Respondents who know all prevention methods (AOR: 8.1, 95%CI: 1.3-51.9) are more likely to aware of COVID-19 than its counterpart.Conclusion: In this study, a low awareness level towards COVID-19 observed, and programs to improve awareness towards COVID-19 are essential to prevent and control the pandemic.
Genome-Wide Identification and Characterization of WRKY Gene Family in Camelina Sativa
Authors: Song Yanan , Cui Hongli , Shi Ying , Xue Jinai , Ji Chunli , Zhang Chunhui , Li Runzhi 
Published: July 2020

Abstract
Background: WRKY gene family is one of the largest transcription factor families and WRKY proteins (WRKYs) have the complex biological functions to regulate plant metabolic processes. Although the WRKY genes were identified in many species and the functions were verified, there were no reports of Camelina sativa WRKY genes.Results: In this investigation, a total of 202 CsWRKY genes were identified and encoded 242 CsWRKYs. The CsWRKYs were further classified into three major groups according to their structure and phylogeny. The comprehensive analysis showed the characteristic sequences of CsWRKYs were conserved in the evolutionary process. In addition, the 137 segmental duplication events were the major force to expand the CsWRKY members in evolution. Compared with other reported plant species, CsWRKYs family as the largest WRKY gene family had maximum members. Furthermore, expression profiling indicated that different CsWRKY members exhibited differently in shoots and roots, and some CsWRKY genes were also up-regulated to varying degrees under salt stress in shoots.Conclusions: In this research, a detailed overview of CsWRKY family genes and expression patterns offered precious information for understanding the potential evolutionary process and the biological functions of CsWRKY genes, which was useful for the further characteristic research of CsWRKY genes and the development of high-quality Camelina sativa varieties.