bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relational processes and psychological adjustment among young adults with cancer: The role of technology‐related communication
Authors: Darabos Katie , Hoyt Michael A. , Ford Jennifer S. 
Published: November 2019

AbstractObjectiveLittle attention has been paid to understanding how engaging in cancer‐related interpersonal exchanges via varying modes of communication influences psychological well‐being among young adults with cancer. This study explored the moderating role of communication mode on the relationship of relational processes of disclosure and responsiveness with psychological well‐being.Methods61 young adults with cancer (Mage = 34.59, SD = 4.82) completed a questionnaire about their most recent cancer‐related conversation. Participants reported on communication mode (ie, face‐to‐face, text message, and phone call) and relational processes of self‐ and support member‐ disclosure of thoughts, information, and feelings and how accepted, cared for, and understood they felt within the cancer‐related conversation. Cancer adjustment measures included functional well‐being and depressive symptoms.ResultsThere were no main effects of communication mode or relational processes. However, communication mode did moderate the relationship between relational processes and cancer adjustment. Greater relational processes of disclosure and responsiveness were associated with better functional well‐being and lower depressive symptoms only among those who engaged in their most recent cancer‐related conversation through technology‐related communication and not for those engaged in face‐to‐face communication.ConclusionRelational processes that are likely to benefit psychological adjustment after cancer appear to be particularly advantageous over technology‐based communication. Young adults commonly report feelings of social isolation and psychological distress after cancer. These findings suggest that technology‐related communication holds promise as a way to strengthen support‐related communication and protect against distress.
Cancer patients' expectations when undergoing extensive molecular diagnostics—A qualitative study
Authors: Rohrmoser Amy , Pichler Theresia , Letsch Anne , Westphalen C. Benedikt , Keilholz Ulrich , Heinemann Volker , Goerling Ute , Herschbach Peter 
Published: November 2019

AbstractObjectivePrecision cancer medicine (PCM) aims at identifying tumor‐driving molecular characteristics to improve therapy. Despite early successes for some cancers, the approach faces manifold challenges. Patients undergoing extensive molecular diagnostics (MD) may hope for personal benefit, although chances are small. In order to offer suitable support to this group, health‐care professionals need to gain insight into patients' experience. Thus, this study sought to explore the expectations of cancer patients undergoing MD of their tumor.MethodsIn two German Comprehensive Cancer Centers, 30 patients with advanced‐stage cancer who had exhausted conventional treatment and had consented to extensive, research‐oriented MD (whole‐genome sequencing n = 24, panel sequencing n = 6) participated in semi‐structured interviews. Following thematic content analysis by Kuckartz, the interview transcripts were coded for expectations of MD participation and topics closely related. Moreover, patients completed questionnaires on their sociodemographic characteristics, medical history, and psychosocial distress.ResultsPatients reported to be expecting (a) an improvement of their treatment, (b) a contribution to research, and/or (c) additional insight to their own cancer. Further, they described to feel individually appreciated and to have a reason to maintain hope for cure or recovery by participating in MD.ConclusionsMolecular diagnostics participation led patients to feel treated in a more “personalized” way, allowing them a greater sense of control in their situation of severe illness. Oncologists and psycho‐oncologists need to ensure comprehensive information and empathetic support for patients undergoing extensive MD to balance their expectations and actual chances of clinical benefit.
The desire for children among adult survivors of childhood cancer: Psychometric evaluation of a cancer‐specific questionnaire and relations with sociodemographic and psychological characteristics
Authors: Ernst Mareike , Brähler Elmar , Wild Philipp S. , Faber Jörg , Merzenich Hiltrud , Beutel Manfred E. 
Published: November 2019

AbstractObjectiveLong‐term childhood cancer survivors (CCS) are less likely to become parents than their peers of the same age. Previous research has suggested that besides fertility, this outcome is shaped by psychosocial factors such as emotional motives toward having a child. Drawing from a sample of CCS with survival times >25 years, we present the validation of a questionnaire assessing cancer‐specific reproductive motives and concerns.MethodsWe evaluated the cancer‐specific version of the Leipzig Questionnaire of Motives to have a Child (LKM‐C) in a register‐based sample of adult CCS (N = 632, 31% had children, 44.5% women). We conducted a confirmatory factor analysis and tested associations with sociodemographic characteristics and psychological symptoms (PHQ‐9, GAD‐2).ResultsThe questionnaire showed good item discrimination parameters and reliability (α = 0.86). The two‐factorial structure was confirmed with the independent scales “return to normalcy” and “illness‐related worries (child's/own health).” On average, CCS reported more motives in favor of a child than worries (P < .001; d = 1.12). Favorable attitudes were associated with the presence of a partnership and children, stronger current desire for a child, and fewer depressive symptoms. Worries were associated with an unfulfilled desire to have a child and elevated levels of depression and anxiety symptoms.ConclusionsThe LKM‐C offers a brief measure of parenthood motivations in long‐term CCS. Having a child signifies return to normalcy, health, fulfillment of life perspectives, and enrichment of the partnership. Less intense worries included illnesses of the child and concerns regarding one's own health. The questionnaire could inform follow‐up care, psychotherapy, and fertility treatments.
Grief over patients, compassion fatigue, and the role of social acknowledgment among psycho‐oncologists
Authors: Engler‐Gross Adi , Goldzweig Gil , Hasson‐Ohayon Ilanit , Laor‐Maayany Rony , Braun Michal 
Published: November 2019

AbstractObjectiveCompassion fatigue—that is, secondary traumatic stress (STS) and burnout—is a traumatic emotional state experienced by health care providers and expressed in a reduced capacity to be interested in and empathic to the suffering of others. Compassion fatigue may be related to grief over patients' loss. We examined the relation between grief and compassion fatigue among psycho‐oncologists while exploring the impact of social acknowledgment on this association. We hypothesized that social acknowledgment would moderate the relation between grief and compassion fatigue.MethodsParticipants were 60 Israeli psycho‐oncologists in a cross‐sectional study. Measures consisted of a demographic questionnaire, the Texas Revised Inventory of Grief‐Present, the Social Acknowledgment questionnaire, and the Professional Quality of Life Questionnaire.ResultsThe participants reported relatively high levels of grief and high levels of compassion fatigue. Grief and compassion fatigue were significantly positively associated (STS: r = 0.41, p < 0.01; Burnout: r = 0.45, p < 0.01). A k‐means cluster analysis based on social acknowledgment and grief yielded three meaningful clusters: High Grief‐Low Social Acknowledgment; Medium Grief‐High Social Acknowledgment; and Low Grief‐Medium Social Acknowledgment. Levels of STS in the first cluster were significantly higher in comparison to levels of STS in each of the other clusters (F = 6.22, p < 0.01).ConclusionsPsycho‐oncologists experience patient loss as part of their daily work. In response, they may develop grief reactions. This grief, when it is not perceived by them as being socially acknowledged, may result in high levels of STS: a phenomenon with undesirable personal and professional implications.
The interactions of PhSPL17 and PhJAZ1 mediate the on‐ and off‐year moso bamboo (Phyllostachys heterocycla) resistance to the Pantana phyllostachysae larval feeding
Authors: Li Yuhong , Lin Bairong , Zhu Tengfei , Zhang Huafeng , Su Jun 
Published: November 2019

AbstractBACKGROUNDThe immunity of moso bamboo (Phyllostachys heterocycle) to insect defoliator outbreaks differs between on‐years to off‐years; however, the underlying genetic mechanisms remain unknown. In this study, the genetic relationships of functional genes conferring pest resistance were investigated.RESULTSPhJAZ1 (Phyllostachys heterocycla JASMONATE ZIM‐domain protein 1) exhibited the highest enrichment and was expressed at higher levels in the leaves of on‐year bamboo plants compared with off‐year, whereas the expression of PhSPL17 (Phyllostachys heterocycla SQUAMOSA Promoter binding protein‐Like 17) showed the reverse pattern. The expression pattern of PhJAZ1 differed in on‐ and off‐year bamboo (i.e., decreasing in the off‐year with no obvious change in the on‐year) after feeding by Pantana phyllostachysae (lepidopteran caterpillar of moso bamboo). Due to the lack of a genetic transformation system, the model plant Arabidopsis was used for the investigation of the genetic relationships between PhJAZ1 and PhSPL17. Overexpression of the PhJAZ1 protein in Arabidopsis showed a negative impact on the survival ratio and weight of third‐instar Helicoverpa armigera (Arabidopsis leaf‐feeding lepidopteran caterpillar). Transcriptional suppression of PhJAZ1 by PhSPL17 was observed, which was able to reveal the reverse expression pattern of PhJAZ1 and PhSPL17.CONCLUSIONTogether, these results suggest that on‐ and off‐years (leaf age) regulate the expression of PhSPL17, which negatively regulates the expression of PhJAZ1 to generate differential response to Jasmonate. This study is the first to detail the genetic connection between leaf age and Jasmonate response in moso bamboo and provides a foundation for further pest control via the genetic breeding of moso bamboo. © 2019 Society of Chemical Industry
Monitoring process variation using modified EWMA
Authors: Saghir Aamir , Aslam Muhammad , Faraz Alireza , Ahmad Liaquat , Heuchenne Cedric 
Published: November 2019

AbstractA new control chart, namely, modified exponentially weighted moving average (EWMA) control chart, for monitoring the process variance is introduced in this work by following the recommendations of Khan et al.15 The proposed control chart deduces the existing charts to be its special cases. The necessary coefficients, which are required for the construction of modified EWMA chart, are determined for various choices of sample sizes and smoothing constants. The performance of the proposed modified EWMA is evaluated in terms of its run length (RL) characteristics such as average RL and standard deviation of RL. The efficiency of the modified EWMA chart is investigated and compared with some existing control charts. The comparison reveals the superiority of proposal as compared with other control charts in terms of early detection of shift in process variation. The application of the proposal is also demonstrated using a real‐life dataset.
Asynchronous H∞ filtering of continuous‐time Markov jump systems
Authors: Fang Mei , Dong Shanling , Wu Zheng‐Guang 
Published: November 2019

SummaryThe paper investigates the asynchronous H∞ filtering design problem for continuous‐time linear systems with Markov jump. The hidden Markov jump principle is applied to represent the asynchronous situation between the target system and the designed filter. Via a Lyapunov technique, two sufficient conditions are developed to guarantee that the filtering error system is stochastically stable with a prescribed H∞ noise attenuation level. Furthermore, three filtering design approaches are developed in the form of linear matrix inequalities. Finally, one example is provided to show the effectiveness and feasibility of the developed methods.
Torii: An aspect‐based sentiment analysis system that can mine conditions
Authors: Gallego Fernando O. , Corchuelo Rafael 
Published: November 2019

SummaryAspect‐based sentiment analysis systems are a kind of text‐mining systems that specialize in summarizing the sentiment that a collection of reviews convey regarding some aspects of an item. There are many cases in which users write their reviews using conditional sentences; in such cases, mining the conditions so that they can be analyzed is very important not to misinterpret the corresponding sentiment summaries. Unfortunately, current commercial systems or research systems neglect conditions; current frameworks and toolkits do not provide any components to mine them; furthermore, the proposals in the literature are insufficient because they are based on handcrafted patterns that fall short regarding recall or machine learning procedures that are tightly bound with a specific language and require too much configuration. In this article, we present Torii, which is a system that loads a collection of reviews, discovers the aspects on which they report, and summarizes the sentiment that is conveyed on them taking into account the existing conditions, if any. We also describe its architecture, our approach to mine conditions, and our experimental analysis on a large multilingual data set with reviews from multiple categories. To the best of our knowledge, Torii is the first proposal that addresses aspect‐based sentiment analysis taking conditions into account.
Constitutive relationships for CNF‐reinforced engineered cementitious composites and CNF‐reinforced lightweight engineered cementitious composites at ambient and elevated temperatures
Authors: Hamidi Fatemeh , Aslani Farhad 
Published: November 2019

AbstractOwing to their unique mechanical performance for both seismic and non‐seismic applications, carbon nanofiber (CNF)‐reinforced engineered cementitious composites (ECCs) and CNF‐reinforced lightweight ECCs (LWECCs) have been received great attentions since their introduction. Due to the crucial roles of material selection and environmental conditions on the mechanical performance of cementitious composites, and thus, the structural performance during the service life of civil engineering structures, analytical studies establishing the constitutive relationships for the mechanical properties of any cementitious composite are of great importance. In this study, the constitutive relationships for the mechanical properties of CNF‐reinforced ECC, as well as, hollow glass microsphere (HGM)‐based LWECC and CNF‐reinforced HGM‐based LWECC have been developed. The proposed models include compressive strength, flexural strength, and compressive stress–strain relationships at both ambient and elevated temperatures. Furthermore, the available experimental results have been applied so that the generality and workability of the established models can be evaluated. The results indicated that to establish more reliable and accurate constitutive relationships, more researches and experimental data for CNF‐reinforced ECC and LWECC with and without CNF reinforcements are essential.
Verifying SysML activity diagrams using formal transformation to Petri nets
Authors: Huang Edward , McGinnis Leon F. , Mitchell Steven W. 
Published: November 2019

AbstractThe development of contemporary systems is an extremely complex process. One approach to modeling system behavior uses activity diagrams from Unified Modeling Language (UML)/System Modeling Language (SysML), providing a standard object‐oriented graphical notation and enhancing reusability. However, UML/SysML activity diagrams do not directly support the kind of analysis needed to verify the system behavior, such as might be available with a Petri net (PN) model. We show that a behavior model represented by a set of fUML‐compliant modeling elements in UML/SysML activity diagrams can be transformed into an equivalent PN, so that the analysis capability of PN can be applied. We define a formal mathematical notation for a set of modeling elements in activity diagrams, show the mapping rules between PN and activity diagrams, and propose a formal transformation algorithm. Two example system behavior models represented by UML/SysML activity diagrams are used for illustration.
Microcystin‐LR exposure disrupts the insulin signaling pathway in C2C12 mice muscle cell line
Authors: Ma Tianfeng , Cao Naifang , Chen Kele , Wang Hao , Xu Lihong , Xu Chun , Huang Pu 
Published: November 2019

AbstractMicrocystin‐LR (MC‐LR) is a widely produced monocyclic heptapeptides in eutrophication waterbodies. MC‐LR can induce various toxic effects in different cells. Our previous studies have found that MC‐LR exposure can disrupt insulin signaling pathway in human liver cells (HL 7702). Skeletal muscle is one of the major organs for glucose disposal and responsive to insulin. However, the effects of MC‐LR on insulin signaling pathway in muscle cells have not been fully explored. By using C2C12 mice muscle cells, this study aims to investigate the toxic effects of MC‐LR in muscle cells with a focus on its effects on insulin signaling pathways. It was found that MC‐LR entered into cells and inhibited protein phosphatase 2A (PP2A) significantly. Furthermore, MC‐LR increased phosphorylation of Ser302, Ser307, Ser612 of insulin receptor substrate 1, AKT‐Ser473, GSK3α‐Ser21, and S6K1‐Thr389 by inhibiting the activity of PP2A. The results in this study demonstrate that exposure of MCLR can disrupt the insulin pathway in muscle cells.
Nuclear sorting of RNA
Authors: Garland William , Jensen Torben Heick 
Published: November 2019

AbstractThe majority of the mammalian genome is transcribed by RNA polymerase II, yielding a vast amount of noncoding RNA (ncRNA) in addition to the standard production of mRNA. The typical nuclear biogenesis of mRNA relies on the tightly controlled coupling of co‐ and post‐transcriptional processing events, which ultimately results in the export of transcripts into the cytoplasm. These processes are subject to surveillance by nuclear RNA decay pathways to prevent the export of aberrant, or otherwise “non‐optimal,” transcripts. However, unlike mRNA, many long ncRNAs are nuclear retained and those that maintain enduring functions must employ precautions to evade decay. Proper sorting and localization of RNA is therefore an essential activity in eukaryotic cells and the formation of ribonucleoprotein complexes during early stages of RNA synthesis is central to deciding such transcript fate. This review details our current understanding of the pathways and factors that direct RNAs towards a particular destiny and how transcripts combat the adverse conditions of the nucleus.This article is categorized under:
RNA Export and Localization > Nuclear Export/Import
RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Higgs Parity grand unification
Authors: Hall Lawrence J. , Harigaya Keisuke 
Published: November 2019

Abstract
The vanishing of the Higgs quartic coupling of the Standard Model at high energies may be explained by spontaneous breaking of Higgs Parity. Taking Higgs Parity to originate from the Left-Right symmetry of the SO(10) gauge group, leads to a new scheme for precision gauge coupling unification that is consistent with proton decay. We compute the relevant running of couplings and threshold corrections to allow a precise correlation among Standard Model parameters. The scheme has a built-in solution for obtaining a realistic value for mb/mτ , which further improves the precision from gauge coupling unification, allowing the QCD coupling constant to be predicted to the level of 1% or, alternatively, the top quark mass to 0.2%. Future measurements of these parameters may significantly constrain the detailed structure of the theory. We also study an SO(10) embedding of quark and lepton masses, showing how large neutrino mixing is compatible with small quark mixing, and predict a normal neutrino mass hierarchy. The strong CP problem may be explained by combining Higgs Parity with space-time parity.
Bilateral reversed palmaris longus muscle: a case report and systematic literature review
Authors: Longhurst Georga , Stone Danya , Mahony Nick 
Published: November 2019

Abstract

Purpose
We present a case of a bilateral reversed palmaris longus muscle and a systematic review of the literature on this anatomical variation.

Methods
Routine dissection of a 90-year-old male cadaver revealed a rare bilateral reversed palmaris longus. This was documented photographically, and length and relation to anatomical landmarks were recorded. This finding stimulated a systematic review of the literature on the reversed palmaris longus variation, from which measurements were collated and statistical analysis performed to determine the prevalence, average length, relationship to side and sex, and to discuss its clinical and evolutionary implications.

Results
The average length of the muscle belly and tendon of reversed palmaris longus was 135 mm and 126 mm, respectively. Statistical analysis revealed no disparity in presentation due to sex and side; however, bilateral reversed palmaris longus has only been reported in males. A high proportion (70.8%) of reversed palmaris longus were discovered in the right upper limb compared to the left.

Conclusion
Variations in palmaris longus are purported to be as a result of phylogenetic regression. Clinically, patients with this variant may present with pain or swelling of the distal forearm, often as a result of intense physical exertion related to occupation or sport. Clinicians should be aware of this muscle variant as its presence could lead to confusion during tendon allograft harvesting procedures in reconstructive and tendon grafting surgery.