bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality after transcatheter versus surgical aortic valve replacement: an updated meta-analysis of randomised trials
Authors:   ALICE (All-Literature Investigation of Cardiovascular Evidence) Group, Takagi H. , Hari Y. , Nakashima K. , Kuno T. , Ando T. 
Published: March 2020

AbstractBackgroundTo determine whether transcatheter aortic valve implantation (TAVI) improves early (30-day) and midterm (1-year) mortality compared with surgical aortic valve replacement (SAVR), we performed an updated meta-analysis of all the currently available randomised controlled trials (RCTs).MethodsTo identify all RCTs providing both 30-day and 1‑year mortality after TAVI versus SAVR, PubMed and ClinicalTrials.gov were searched up to and including July 2019. A risk difference (RD) and its 95% confidence interval were generated using data of prespecified outcomes in both the TAVI and SAVR groups. Study-specific estimates were pooled using inverse variance-weighted averages of RDs in the random-effects model.ResultsWe identified seven eligible high-quality RCTs including a total of 7631 as-treated patients. Pooled analyses demonstrated significantly lower 30-day (RD −0.60%;p = 0.046) and 1‑year all-cause mortality (RD −1.12%;p = 0.03) after TAVI than after SAVR. No funnel plot asymmetry was detected for 30-day and 1‑year mortality. Meta-regression analyses indicated that RDs of 30-day and 1‑year mortality between TAVI and SAVR were not modulated by mean Society of Thoracic Surgeons Predicted Risk of Mortality score. Bleeding complications at 30 days and 1 year and stage 2/3 acute kidney injury at 30 days were significantly less frequent after TAVI than after SAVR, whereas major vascular complications and new permanent pacemaker implantation at 30 days and 1 year were significantly more frequent after TAVI than after SAVR.ConclusionThe best evidence from the present meta-analysis of all the currently available RCTs suggests that TAVI may reduce 30-day and 1‑year all-cause mortality compared with SAVR.
AP4B1-associated hereditary spastic paraplegia: expansion of phenotypic spectrum related to homozygous p.Thr387fs variant
Authors: Szczałuba Krzysztof , Mierzewska Hanna , Śmigiel Robert , Kosińska Joanna , Koppolu Agnieszka , Biernacka Anna , Stawiński Piotr , Pollak Agnieszka , Rydzanicz Małgorzata , Płoski Rafał 
Published: March 2020

AbstractBiallelic mutations in the AP4B1 gene, encoding adaptor-related protein complex 4 beta-1 subunit, have been recognized as an important cause of a group of conditions leading to adaptor-related protein complex 4 (AP4)-associated hereditary spastic paraplegia (SPG47). We describe a homozygous, known variant c.1160_1161delCA (p.Thr387fs) that was found in the largest ever group of patients coming from four families. The patients exhibited early hypotonia progressing to spastic paraplegia, microcephaly, epilepsy, and central nervous system (CNS) defects and global developmental delay that are consistent with the nature of SPG47. Our findings expand phenotypic spectrum of SPG47 to include polymorphic seizures, mild/moderate intellectual disability, and intracerebral cysts as well as point to founder mutation in AP4 deficiency disorders in apparently non-consanguineous Polish families without shared ancestry.
Identification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer
Authors: Serrano-Oviedo Leticia , Nuncia-Cantarero Miriam , Morcillo-Garcia Sara , Nieto-Jimenez Cristina , Burgos Miguel , Corrales-Sanchez Veronica , Perez-Peña Javier , Győrffy Balázs , Ocaña Alberto , Galán-Moya Eva María 
Published: March 2020

Abstract
Purpose
Triple negative breast cancers (TNBCs) are enriched in cells bearing stem-like features, i.e., cancer stem cells (CSCs), which underlie cancer progression. Thus, targeting stemness may be an interesting treatment approach. The epigenetic machinery is crucial for maintaining the stemness phenotype. Bromodomain and extra-terminal domain (BET) epigenetic reader family members are emerging as novel targets for cancer therapy, and have already shown preclinical effects in breast cancer. Here, we aimed to evaluate the effect of the BET inhibitor JQ1 on stemness in TNBC.

Methods
Transcriptomic, functional annotation and qRT-PCR studies were performed on JQ1-exposed TNBC cells in culture. The results obtained were confirmed in spheroids and spheroid-derived tumours. In addition, limiting dilution, secondary and tertiary tumour sphere formation, matrigel invasion, immunofluorescence and flow cytometry assays were performed to evaluate the effect of JQ1 on CSC features. For clinical outcome analyses, the online tool Kaplan-Meier Plotter and an integrated response database were used.

Results
We found that JQ1 modified the expression of stemness-related genes in two TNBC-derived cell lines, MDA-MB-231 and BT549. Among these changes, the CD44 Antigen/CD24 Antigen (CD44/CD24) ratio and Aldehyde Dehydrogenase 1 Family Member A1 (ALDH1A1) expression level, i.e., both classical stemness markers, were found to be decreased by JQ1. Using a validated spheroid model to mimic the intrinsic characteristics of CSCs, we found that JQ1 decreased surface CD44 expression, inhibited self-renewal and invasion, and induced cell cycle arrest in G0/G1, thereby altering the stemness phenotype. We also found associations between four of the identified stemness genes, Gap Junction Protein Alpha 1 (GJA1), CD24, Epithelial Adhesion Molecule (EPCAM) and SRY-related HMG-box gene 9 (SOX9), and a worse TNBC patient outcome. The expression of another two of the stemness-related genes was found to be decreased by JQ1, i.e., ATP Binding Cassette Subfamily G Member 2 (ABCG2) and RUNX2, and predicted a low response to chemotherapy in TNBC patients, which supports a role for RUNX2 as a potential predictive marker for chemotherapy response in TNBC.

Conclusions
We identified a stemness-related gene panel associated with JQ1 and describe how this inhibitor modifies the stemness landscape in TNBC. Therefore, we propose a novel role for JQ1 as a stemness-targeting drug. Loss of the stem cell phenotype via JQ1 treatment could lead to less aggressive and more chemo-sensitive tumours, reflecting a better patient prognosis. Thus, the identified gene panel may be of interest for the clinical management of patients with aggressive TNBC.
Safety and tolerability of 6-month supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink in sarcopenic older adults
Authors:   the PROVIDE Consortium, Bauer Jürgen M. , Mikušová Lucia , Verlaan Sjors , Bautmans Ivan , Brandt Kirsten , Donini Lorenzo M. , Maggio Marcello , Mets Tony , Wijers Sander L. J. , Garthoff Jossie A. , Luiking Yvette , Sieber Cornel , Cederholm Tommy 
Published: March 2020

Abstract
Aims
Safety and tolerability of prolonged supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink (WP-MND) was evaluated in sarcopenic older adults.

Methods
A 13-week double-blinded, randomized, isocaloric placebo-controlled trial (PROVIDE study; n = 380) was extended with a voluntary 13-week open-label extension (OLE). OLE participants were randomized to receive daily 1 or 2 servings of WP-MND (21 g protein, 3 g leucine, 10 µg vitD and 500 mg calcium per serving). Gastro-intestinal tolerability, kidney function and serum levels of calcidiol, parathyroid hormone (PTH) and calcium were evaluated at week 0, 13 and 26.

Results and discussion
In response to the high daily protein intake (median1.5; IQR: 1.3, 1.7 g/kg BW/day), the estimated glomerular filtration rate (eGFR) increased in the test group during the RCT (p = 0.013). The same trend was observed for those participants with moderate chronic kidney disease. During OLE no eGFR change was observed in any of the groups. Serum calcidiol and calcium reached a plateau after 13-week WP-MND supplementation. As expected, PTH significantly changed in the opposite direction, decreasing during RCT in the test group (T vs C: p < 0.001) and during OLE in former control groups. During RCT, 20/366 participants with normal baseline calcidiol reached levels ≥ 100 nmol/L (T: n = 18; C: n = 2) and 6 developed albumin-corrected calcium levels > 2.55 mmol/L (T: n = 3; C: n = 3), without associated adverse events.

Conclusion
A 6 months intervention with up to 2 servings of WP-MND did neither result in kidney function deterioration nor symptoms of vitamin D or calcium toxicity. The product was overall well tolerated.
Linear Maps Which are Anti-derivable at Zero
Authors: Abulhamil Doha Adel , Jamjoom Fatmah B. , Peralta Antonio M. 
Published: March 2020

AbstractLet$$T:A\rightarrow X$$T:A→Xbe a bounded linear operator, whereAis a$$\hbox {C}^*$$C∗-algebra, andXdenotes an essential BanachA-bimodule. We prove that the following statements are equivalent:(a)Tis anti-derivable at zero (i.e.,$$ab =0$$ab=0inAimplies$$T(b) a + b T(a)=0$$T(b)a+bT(a)=0);(b)There exist an anti-derivation$$d:A\rightarrow X^{**}$$d:A→X∗∗and an element$$\xi \in X^{**}$$ξ∈X∗∗satisfying$$\xi a = a \xi ,$$ξa=aξ,$$\xi [a,b]=0,$$ξ[a,b]=0,$$T(a b) = b T(a) + T(b) a - b \xi a,$$T(ab)=bT(a)+T(b)a-bξa,and$$T(a) = d(a) + \xi a,$$T(a)=d(a)+ξa,for all$$a,b\in A$$a,b∈A.We also prove a similar equivalence whenXis replaced with$$A^{**}$$A∗∗. This provides a complete characterization of those bounded linear maps fromAintoXor into$$A^{**}$$A∗∗which are anti-derivable at zero. We also present a complete characterization of those continuous linear operators which are$$^*$$∗-anti-derivable at zero.
Liquid-Phase Xylene Adsorption in Unary, Binary, and Ternary Solute Systems Using Raw and Ni2+ Ion-Exchanged Clinoptilolite: Experimental Study and Thermodynamic Assessment
Authors: Salarvand Atefeh , Falamaki Cavus 
Published: March 2020

AbstractThe adsorptive behavior of clinoptilolite (Cpt) zeolite in its raw and nickel-exchanged form towards m-xylene/p-xylene/ethylbenzene unary, binary, and ternary mixtures was investigated. The motivation behind the research was to elucidate whether Cpt in its raw or ion-exchanged form could exhibit distinctive selective adsorption behavior. The natural Cpt (Si/Al atomic ratio = 4.59) was ion-exchanged twice with 0.5 M Ni(NO3)2 solution at 80°C for 6 h. Adsorption experiments were done at 40°C, using a 4 vol.% solution of the aromatic materials in iso-octane. The maximum amount of the total specific adsorption capacity for binary solute systems was ~0.8 and ~2.0 mmol g–1 for the raw and ion-exchanged Cpt, respectively. For the ternary solute systems, unexpectedly, this capacity increased to ~2.0 and ~3.0 mmol g–1, respectively. For binary mixtures, both forms of Cpt were selective for p-xylene. For ternary mixtures, both forms exhibited a clear selectivity for m-xylene but the Ni-exchanged Cpt was significantly higher over the concentration range studied. The unexpected increase in the adsorption capacity in ternary systems was attributed to the expulsion of tightly bound trace water molecules hindering the access of xylene molecules to the 10-member ring channels of the zeolite framework. Substitution of Mg2+ by Ni2+ in the 10-member ring channels enhanced the adsorption capacity by providing more space and stronger electrostatic interactions between the new cation and the polar m-xylene molecule.
Meta-Analysis Reveals Potential Influence of Oxidative Stress on the Airway Microbiomes of Cystic Fibrosis Patients
Authors: Shi Xing , Gao Zhancheng , Lin Qiang , Zhao Liping , Ma Qin , Kang Yu , Yu Jun 
Published: March 2020

Abstract
The lethal chronic airway infection of the cystic fibrosis (CF) patients is predisposed by colonization of specific CF-philic pathogens or the CF microbiomes, but key processes and reasons of the microbiome settlement in the patients are yet to be fully understood, especially their survival and metabolic dynamics from normal to diseased status under treatment. Here, we report our meta-analysis results on CF airway microbiomes based on metabolic networks reconstructed from genome information at species level. The microbiomes of CF patients appear to engage much more redox-related activities than those of controls, and by constructing a large dataset of anti-oxidative stress (anti-OS) genes, our quantitative evaluation of the anti-OS capacity of each bacterial species in the CF microbiomes confirms strong conservation of the anti-OS responses within genera and also shows that the CF pathogens have significantly higher anti-OS capacity than commensals and other typical respiratory pathogens. In addition, the anti-OS capacity of a relevant species correlates with its relative fitness for the airways of CF patients over that for the airways of controls. Moreover, the total anti-OS capacity of the respiratory microbiome of CF patients is collectively higher than that of controls, which increases with disease progression, especially after episodes of acute exacerbation and antibiotic treatment. According to these results, we propose that the increased OS in the airways of CF patients may play an important role in reshaping airway microbiomes to a more resistant status that favors the pre-infection colonization of the CF pathogens for a higher anti-OS capacity.
Influence of Sex Hormones on the Relationship Between Body Fat and Glycated Albumin Levels
Authors: Xu Yiting , Ma Xiaojing , Shen Yun , Wang Yufei , Zhou Jian , Bao Yuqian 
Published: March 2020

Abstract

Background
Previous studies have reported that glycated albumin (GA) is affected by body fat distribution. Sex hormones are reported to play an important role in fat metabolism.

Aim
This study aimed to explore the influence of sex hormones on the relationship between body fat and GA in a community population.

Methods
We recruited 763 middle-aged and elderly subjects with normal glucose tolerance from communities. GA was determined using the enzyme method, and serum estradiol (E2), total testosterone, and sex hormone–binding globulin (SHBG) were detected using chemiluminescent microparticle immunoassays.

Outcome
There was a statistically significant association between SHBG and GA remained after adjusting for body fat in both men and women.

Results
The average serum GA levels were 13.40 ± 1.10% in the 298 men and 465 postmenopausal women included in this study. GA presented a significant downward trend with increasing quartiles of total fat mass (FM), limb FM, and trunk FM in both men and women (all P for trend &lt; .01). In men, total testosterone, free testosterone, and SHBG were positively correlated with GA (both P &lt; .01), and the correlation between SHBG and GA remained after adjusting for body fat (P &lt; .01). In women, E2, free testosterone, bioactive testosterone, and SHBG were correlated with GA (all P &lt; .01); furthermore, the positive correlation between SHBG and GA and the inverse correlation between E2 and GA remained after adjusting for body fat (both P &lt; .05). Multivariate linear regression analyses showed that in addition to trunk FM, SHBG was positively correlated with GA in both men and women (standardized β = 0.136, P = .035; standardized β = 0.101, P = .033); however, E2 was not independently correlated with GA in women.

Clinical Implications
SHBG may contribute to the influence of body fat, especially trunk fat on GA levels.

Strengths & Implications
This study used an automated bioelectrical impedance analyzer to measure segmental body composition including limb FM and trunk FM and further investigated the role of segmental body fat in the correlation between SHBG and GA. Sex hormones may explain in part why body fat content and distribution can alter GA levels.

Conclusion
SHBG is positively correlated with serum GA levels, and this correlation is independent of total or segmental body fat.
Meta-Encyclopaedic Reflections on the Beginning of Philosophy
Authors: Başdaş Umur 
Published: March 2020

AbstractSince in Hegel's view the end of philosophy coincides with its beginning, it is reasonable to expect that the end of the Encyclopaedia sheds some light on the Science of Logic. The Encyclopaedia concludes with three syllogisms in which logic, nature and spirit are related to each other in three different ways. This article analyses these three final syllogisms with an eye to how they can contribute to our understanding of the logical movement that starts from pure being. Trendelenburg and Schelling, like many others after them, think that Hegel's project in the Science of Logic is doomed from the start, because there can be no such thing as a non-temporal, purely logical movement. I argue that the three final syllogisms contain Hegel's response to this challenge. I call them ‘meta-encyclopaedic reflections’ in the sense that they take the whole encyclopaedic presentation of the Hegelian system as an object of critical inquiry and identify its limitations. The core of my approach is to examine how each one of these syllogisms situate us, namely the philosophizing subjects, vis-à-vis the world as disclosed by them. They demand that we shift from a third-person to a first-person perspective towards the world. The logical categories initially appear to move of their own accord only due to the limitations of the third-person perspective of the encyclopaedic presentation, which is to be sublated in a higher, first-person perspective. Hence, Hegel would happily admit that a purely logical movement is a mere appearance, but he would also claim that his philosophy can immanently explain the necessity of this appearance in the beginning of philosophy, and explain it better than his critics.
United Nations Security Council Resolution 2474
Authors: Clement Claire 
Published: March 2020

On June 11, 2019, the United Nations (UN) Security Council unanimously adopted Resolution 2474 on missing persons in armed conflict. The resolution marks the first time the Security Council has agreed on a thematic text dedicated to this issue, lending its collective voice to call for more effective implementation of existing obligations towards missing persons—both civilian and military—and their families under international law.
Material Interests, Identity and Linked Fate in Three Countries
Authors: Donnelly Michael J. 
Published: March 2020

AbstractThis article examines the theoretical connections between identity and linked fate, extending the latter concept across three countries and four types of (potential) identity groups. This belief, that what happens to one's ethnic group, religious group, region, or class shapes one's own life chances, is an understudied middle ground between ideational and material drivers of political attitudes. The study uses experimental and observational analyses to show that the strength of individuals' beliefs in linked fate and that belief's consequences vary in systematic and predictable ways. From the very material effect of labor market uncertainty to the highly ideational effect of regional identity, linked fate is a cognitive bridge between two very different kinds of social–psychological experiences that can (and should) be applied across a wide range of countries and groups.
The potential geographical distribution and phenology of Bemisia tabaci Middle East/Asia Minor 1, considering irrigation and glasshouse production
Authors: Kriticos D. J. , De Barro P. J. , Yonow T. , Ota N. , Sutherst R. W. 
Published: March 2020

AbstractThe Bemisia tabaci species complex is one of the most important pests of open field and protected cropping globally. Within this complex, one species (Middle East Asia Minor 1, B. tabaci MEAM1, formerly biotype B) has been especially problematic, invading widely and spreading a large variety of plant pathogens, and developing broad spectrum pesticide resistance. Here, we fit a CLIMEX model to the distribution records of B. tabaci MEAM1, using experimental observations to calibrate its temperature responses. In fitting the model, we consider the effects of irrigation and glasshouses in extending its potential range. The validated niche model estimates its potential distribution as being considerably broader than its present known distribution, especially in the Americas, Africa and Asia. The potential distribution of the fitted model encompasses the known distribution of B. tabaci sensu lato, highlighting the magnitude of the threat posed globally by this invasive pest species complex and the viruses it vectors to open field and protected agriculture.
Effects of photoperiod and relative humidity on diapause termination and post-winter development ofRhagoletis cerasipupae
Authors: Moraiti Cleopatra A. , Köppler Kirsten , Vogt Heidrun , Papadopoulos Nikos T. 
Published: March 2020

AbstractThe European cherry fruit fly,Rhagoletis cerasi(Diptera: Tephritidae), is a univoltine species that undergoes obligatory summer–winter diapause at pupal stage in the soil (2–5 cm) beneath host trees. To study the effects of photoperiod and relative humidity on diapause termination and post-winter developmental duration ofR. cerasi, pupae collected from Dossenheim (Germany) were exposed to different photoperiod or relative humidity regimes during a chilling period ranging from 2 to 8.5 months. Specifically, pupae were exposed to four photoperiod regimes: (a) light conditions (24L:00D), (b) dark conditions (00L:24D), (c) short photoperiod (08L:16D) and (d) long photoperiod (16L:08D), as well as to three relative humidity regimes: (a) low (40% RH), (b) medium (60% RH) and (c) high (70–80% RH). Data revealed that relative humidity is not a significant predictor of diapause termination, but it affects the post-winter developmental period. Higher relative humidity promotes post-winter pupae development. On the other hand, photoperiod significantly affected both diapause termination and post-winter development ofR. cerasipupae. Light conditions (24L:00D) accelerate adult emergence, particularly for females. Regardless of the photoperiod (24L:00D, 00L:24D, 08L:16D), rates of adult emergence were high (>75%) for chilling intervals longer than 6.5 months. Nonetheless, exposure to a long day photoperiod (16L:08D), during chilling, dramatically reduced the proportion of adult emergence following 6 months exposure to chilling. Our findings broaden the understanding of factors regulating diapause responses in European cherry fruit fly, local adaptation and synchronization of adult emergence with the ripening period of major hosts.