bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization, optimization and kinetics study of acetaminophen degradation by Bacillus drentensis strain S1 and waste water degradation analysis
Authors: Chopra Sunil , Kumar Dharmender 
Published: February 2020

Abstract
Background
In this study, the biodegradation of N-acetyl-para-aminophenol also known as acetaminophen (APAP, paracetamol) was studied by bacterial strain Bacillus drentensis strain S1 (accession no. KY623719) isolated from sewage sample.

Results
The Bacillus drentensis strain S1 was isolated from the sewage sample using the enrichment culture method. As per our knowledge this is the first Bacillus drentensis strain reported for the degradation of APAP. In this study a 20-L batch reactor was employed for degradation of APAP. The maximum specific growth rate (μmax) was observed at 400 mg/L concentration of APAP. The pilot-scale anaerobic batch reactor of was stable and self-buffered. The degradation in pilot-scale reactor was slow as compared to batch experiments due to fluctuation in pH and exhaustion of nutrients. Design-Expert® software was used for optimization of conditions for APAP degradation; such as temperature (40 °C), pH (7.0), concentration of APAP (300 g/L) and agitation speed (165 rpm). The FTIR and GC–MS were used to identify the degradation metabolites. The intermediates of degradation like 2-isopropyl-5-methylcyclohexanone and phenothiazine were observed, based on these results the metabolic pathway has been predicted.

Conclusions
The optimization, kinetic, batch study and pilot study indicates the potential of Bacillus drentensis strain S1 for degradation of acetaminophen. The experimental design, optimization and statistical analysis were performed by Design Expert® software. The optimal growth condition for Bacillus drentensis strain S1 was found to be at temperature 40 °C, pH 7, acetaminophen at concentration of 300 (mg/L) and agitation speed 165 rpm. The GC–MS and FTIR was used for identification of metabolites produced during acetaminophen degradation and the partial metabolic pathway for degradation of acetaminophen was also proposed .
Immunotherapy-related adverse effects on 18F-FDG PET/CT imaging
Authors: Gandy Nemi , Arshad Mubarik A , Wallitt Kathryn L , Dubash Suraiya , Khan Sameer , Barwick Tara D 
Published: February 2020

18F-Fluorodeoxyglucose positron emission tomography/CT imaging plays a key role in oncological imaging including in staging, radiotherapy planning, treatment response and recurrence assessment. Immunotherapies represent a major advance in cancer therapy for a number of tumours with resulting survival benefit. However, a wide range of immune related adverse events (irAEs), some of which can be apparent on imaging, have been reported. These involve many organ systems but particularly endocrine, cutaneous and gastrointestinal systems. Early detection of irAEs is essential to aid diagnosis and management of patients and to reduce associated morbidity. In addition, it is important to not mistake treatment related effects for disease.
This pictorial review aims to identify common irAEs and changes seen on 18F-fluorodeoxyglucose positron emission tomography/CT.
A rare imaging case of bilateral plasmacytoma of the breast
Authors: Eden Joleen Kirsty , Borgen Rita , Haq Rabea , Dobrashian Richard 
Published: February 2020

This case reports on secondary extramedullary multiple myeloma within both breasts in the absence of axillary nodal involvement and discusses the difficulty in interpretation with clinical recommendations and learning outcomes. Differentiating plasmacytic lesions in the breast is often difficult as clinical and radiological appearances are known to mimic benignity and high-grade primary breast cancer. Extramedullary presentation can determine progression of the disease and can necessitate cross-sectional imaging. Therefore definitive diagnosis is essential as the clinical management of the patient may be altered.
Effect of an educational programme on the attitudes towards patient safety of operation room nurses
Authors: Habahbeh Atallah A , Alkhalaileh Murad Abdulrahim 
Published: February 2020

Background: A culture of patient safety is one of the cornerstones of good-quality healthcare, and its provision is one of the significant challenges in healthcare environments. Aim: The purpose of this study was to evaluate the effect of a surgical safety educational programme on the attitudes of nurses to patient safety in operating rooms (OR). Design: An interventional one-group pre-/post-test design, which sought to measure changes in OR nurses' attitudes toward patient safety culture. Methods: A simple random sampling technique was used to recruit 66 OR nurses working at six Royal Medical Service hospitals in Amman, Jordan. All participants took part in a 4-hour educational workshop. Pre-tests and post-tests were done. Results: The results of this study showed that OR nurses' attitudes towards a culture of patient safety was originally negative; significant improvement after attending the programme was found (3.3 ± 0.20 versus 3.8 ± 0.30). There was a negative correlation between years of experience and nurses' attitudes towards patient safety. Conclusions: Incorporating courses about safety culture into continuing education programmes may improve nurses' attitudes towards patient safety. Nurses should be qualified to play an important role in creating a culture of patient safety.
Closed Loop Resonator Based Compact UWB Antenna with Single Notched Band Varying between WLAN and X-band for UWB Applications
Authors: Salamin Mohammad Ahmad , Das Sudipta , Zugari Asmaa 
Published: February 2020

AbstractIn this paper, a novel compact UWB antenna with variable notched band characteristics for UWB applications is presented. The designed antenna primarily consists of an adjusted elliptical shaped metallic patch and a partial ground plane. The proposed antenna has a compact size of only 17 × 17 mm2. The suggested antenna covers the frequency range from 3.1 GHz to 12 GHz. A single notched band has been achieved at 7.4 GHz with the aid of integrating a novel closed loop resonator at the back plane of the antenna. This notched band can be utilized to alleviate the interference impact with the downlink X-band applications. Besides, a square slot was cut in the loop in order to obtain a variable notched band. With the absence and the existence of this slot, the notched band can be varied to mitigate interference of the upper WLAN band (5.72–5.82 GHz) and X-band (7.25–7.75 GHz) with UWB applications. A good agreement between measurement and simulation results was achieved, which affirms the appropriateness of this antenna for UWB applications.
Regulation of mitochondrial plasticity by the i-AAA protease YME1L
Authors: Ohba Yohsuke , MacVicar Thomas , Langer Thomas 
Published: February 2020

Abstract
Mitochondria are multifaceted metabolic organelles and adapt dynamically to various developmental transitions and environmental challenges. The metabolic flexibility of mitochondria is provided by alterations in the mitochondrial proteome and is tightly coupled to changes in the shape of mitochondria. Mitochondrial proteases are emerging as important posttranslational regulators of mitochondrial plasticity. The i-AAA protease YME1L, an ATP-dependent proteolytic complex in the mitochondrial inner membrane, coordinates mitochondrial biogenesis and dynamics with the metabolic output of mitochondria. mTORC1-dependent lipid signaling drives proteolytic rewiring of mitochondria by YME1L. While the tissue-specific loss of YME1L in mice is associated with heart failure, disturbed eye development, and axonal degeneration in the spinal cord, YME1L activity supports growth of pancreatic ductal adenocarcinoma cells. YME1L thus represents a key regulatory protease determining mitochondrial plasticity and metabolic reprogramming and is emerging as a promising therapeutic target.
Crystal structure of (2-p-tolylpyrimidine-κ2
C,N)(triphenylphosphane-κ
P) palladium(II), C29H24ClN2PPd
Authors: Liu Hui , Lou Xin-Hua 
Published: February 2020

Abstract
C29H24ClN2PPd, triclinic, P1̄ (no. 2), a = 9.9885(8) Å, b = 11.5836(8) Å, c = 11.6133(9) Å, α = 76.342(6)°, β = 89.821(6)°, γ = 71.435(7)°, V = 1233.96(16) Å3, Z = 2, R
gt(F) = 0.0337, wR
ref(F
2) = 0.0841, T = 291 K.
Meta-analysis comparing placebo responses in clinical trials of painful HIV-associated sensory neuropathy and diabetic polyneuropathy
Authors: Kemp Harriet I. , Eliahoo Joseph , Vase Lene , Nguyen Steffany , Ben Abdallah Arbi , Rice Andrew S.C. , Finnerup Nanna B. , Haroutounian Simon 
Published: February 2020

Abstract

Background and aims
The placebo response has been identified as one factor responsible for the lack of therapeutic trials with positive outcomes in neuropathic pain. Reviews have suggested that certain neuropathic pain conditions, including HIV-associated sensory neuropathy (HIV-SN), exhibit a greater placebo response than other neuropathic aetiologies. If true, such a finding could substantially affect clinical trial design and therapeutic developments for these conditions. This study aimed to identify any difference in placebo response between trials of systemic pharmacological intervention in HIV-SN and a comparable neuropathic condition, diabetic polyneuropathy (DPN) and to identify factors influencing the placebo response.

Methods
A systematic review search to identify randomised, double-blind studies of systemic pharmacological interventions for painful HIV-SN and DPN published between January 1966 and June 2019 was performed. A meta-analysis of the magnitude of placebo response and the proportion of placebo responders was conducted and compared between the two disease conditions. A meta-regression was used to assess for any study and participant characteristics that were associated with the placebo response. Only studies meeting a methodological quality threshold were included.

Results
Seventy-five trials were identified. There was no statistically significant difference in the proportion of placebo responders (HIV-SN = 0.35; versus DPN = 0.27, p = 0.129). The difference observed in the magnitude of the placebo response [pain reduction of 1.68 (1.47–1.88) DPN; 2.38 (1.87–2.98) in HIV-SN] was based on only 2 trials of HIV-SN and 35 of DPN. Potential factors influencing the placebo response such as psychological measures, were reported inconsistently.

Conclusions
We found no statistically significant difference in the placebo response rate between painful HIV-SN and DPN. Too few studies were available that reported the necessary information to clarify potential differences in the magnitude of placebo response or to elucidate parameters that could be contributing such differences.

Implications
The placebo response is one factor that may contribute to a lack of positive trials in neuropathic pain; some etiologies may display larger responses than others. This meta-analysis found no significant difference in placebo response between trials of HIV-associated sensory neuropathy and painful diabetic polyneuropathy, although limited data were available.
Estrategias de descortesía modalizadas deónticamente en inglés en ambientes laborales argentinos
Authors: Cordisco Ariel 
Published: February 2020

Resumen
En este trabajo se identifican estrategias de descortesía modalizadas deónticamente en ambientes laborales argentinos en contacto interlingüístico español-inglés e intercultural argentino-estadounidense en la Ciudad Autónoma de Buenos Aires durante 2012–2014. Se lo hace poniendo el foco de atención en la descortesía producida a través de correos electrónicos empresariales con propósitos laborales escritos en inglés en un medio fuertemente regulado que privilegia, fundamentalmente, funciones transaccionales y procedimentales para asegurar la maximización de sus fines lucrativos. En un corpus natural de 148 correos electrónicos (agrupados en 22 secuencias, con aproximadamente 17.000 palabras), se identificaron cuatro estrategias de descortesía modalizadas deónticamente: ataque por atribución de la responsabilidad, contraataque por impugnación de la responsabilidad, contraataque por acatamiento forzado de la responsabilidad y ataque o contraataque por naturalización de la responsabilidad. A través de estas estrategias, se des-idealiza, desvaloriza y disminuye la imagen social con el propósito ulterior de reconstituir el orden moral que afianza el statu quo de los ambientes laborales estudiados.
Adaptation to Industrial Stressors Through Genomic and Transcriptional Plasticity in a Bioethanol Producing Fission Yeast Isolate
Authors: Vassiliadis Dane , Wong Koon Ho , Blinco Jo , Dumsday Geoff , Andrianopoulos Alex , Monahan Brendon 
Published: February 2020

Abstract
Schizosaccharomyces pombe is a model unicellular eukaryote with ties to the basic research, oenology and industrial biotechnology sectors. While most investigations into S. pombe cell biology utilize Leupold’s 972h- laboratory strain background, recent studies have described a wealth of genetic and phenotypic diversity within wild populations of S. pombe including stress resistance phenotypes which may be of interest to industry. Here we describe the genomic and transcriptomic characterization of Wilmar-P, an S. pombe isolate used for bioethanol production from sugarcane molasses at industrial scale. Novel sequences present in Wilmar-P but not in the laboratory S. pombe genome included multiple coding sequences with near-perfect nucleotide identity to Schizosaccharomyces octosporus sequences. Wilmar-P also contained a ∼100kb duplication in the right arm of chromosome III, a region harboring ght5+, the predominant hexose transporter encoding gene. Transcriptomic analysis of Wilmar-P grown in molasses revealed strong downregulation of core environmental stress response genes and upregulation of hexose transporters and drug efflux pumps compared to laboratory S. pombe. Finally, examination of the regulatory network of Scr1, which is involved in the regulation of several genes differentially expressed on molasses, revealed expanded binding of this transcription factor in Wilmar-P compared to laboratory S. pombe in the molasses condition. Together our results point to both genomic plasticity and transcriptomic adaptation as mechanisms driving phenotypic adaptation of Wilmar-P to the molasses environment and therefore adds to our understanding of genetic diversity within industrial fission yeast strains and the capacity of this strain for commercial scale bioethanol production.
Demographic Losses Due To Alcohol-Related Mortality in Lithuania: Results Obtained Through Combining Death Records with the 2011 Population Census Data
Authors: Stumbrys Daumantas , Jasilionis Domantas , Ambrozaitienė Dalia , Stankūnienė Vlada 
Published: February 2020

This paper presents the results of a study on sociodemographic mortality differentials in Lithuania based on censuslinked mortality data. Population data come from the individual records of the 2011 Population and Housing Census of the Republic of Lithuania. The results of the research demonstrate that education and marital status are very strong predictors of alcohol-related mortality. Among males aged 30 and older, the alcohol-related mortality risk in non-married groups is up to 3.4 times as high as in the group of married males. The alcohol-related mortality risk in lower-education groups is up to 3.7 times as high as in the group of those with higher education. The findings of the study suggest that the elimination of educational differences would allow avoiding 55.7 %, the elimination of marital status differences – 40.2 %, the elimination of ethnic group differences – 11.1 % of alcohol-related deaths.
Long-Lasting Trajectory of Population Ageing in Lithuania: Fundamental and Specific Factors
Authors: Stankūnienė Vladislava 
Published: February 2020

The article analyses the population ageing of Lithuania for almost a hundred years. The aim of the article is to evaluate the trends of population ageing of Lithuania and to analyse the preconditions and factors of the ageing trajectory fluctuation. Based on demographic development theories and methodological insights in the estimation of influence of different factors on the ageing trends, the fundamental and specific changes in the ageing of Lithuanian population are evaluated. The analysis relies on the official information of Lithuania and international population databases.
Research Institute of Urban History
Authors: Konstantinova Victoria , Lyman Ihor 
Published: February 2020

The review is dedicated to activities of Research Institute of Urban History. The main attention turns to directions of the work of the Research Institute:
1. Multifaceted studying of urban history (continuation of individual Institute’s member's studies on various components of the urban past; realization of joint research projects connected with urbanization; organization of conferences and meetings dedicated to urban issues; cooperation with other research in­stitutions and associations involved in studying urban past);
2. Developing a website of the Institute, which should become a platform for communica­tion scholars and the public involved and interested in urban history as well as for publishing articles and archival collections of the Research Institute;
3. Work as editorial board and authors of historical-cultural anthology “Frontiers of the city”.
4. Conducting oral historical research on urban history with the formation of an archive of oral historical narrative (theoretical and practical training for interviewers; preparing and conducting expeditions; systematization, processing the collected materials; preparation of materials for publication);
5. Development and maintenance of the archive of film doc­uments related to urban history (heuristic work in archives; identifying and copying film documents from private collections; participation in creation on the basis of these film documents documentaries and popular science films on the history of cities);
6. Development and maintenance of the depositary of photographs related to the history of “urban space”;
7. Creating in the structure of the Research Institute the Museum of Berdyansk State Pedagog­ical University, which is a broader context may be considered as a museum of the history of education in an urban area; 8. Public activities aimed at popularization of urban history and at the interaction of researchers with society (organization of exhibitions, competitions, etc.; initiation and implementation of public projects).
THE MIDDLE 19TH CENTURY – EARLY 21ST CENTURY FUNCTIONING OF LVIV’S HORONYMS
Authors: Dolynska Maryana 
Published: February 2020

There are official and traditional names of places upon the territory of the town or the city. They have existed from the ancient times till contemporary days. The official ones have been given by the executive body, and the traditional names are describing the place by nearby locations, buildings or natural objects. Toponyms are divided into different classes and subclasses.
Horonyms describe nonlinear structures (territories) and were used to call any places on the town’s area, except for streets or squares. Horonyms do not provide the information about the official administrative division of the contemporary time but were putting traditional names in use.In order to answer the question - how long this class of the city’s names lasted, one has to base on retrospective comparison of the pre-statistical source. The contemporary vocabulary of Lviv’s dialect (“Leksykon lvivskyy povazhno i na zhart”) have fixed 65 horonyms of Lviv’s area, which currentlyare being used by city dwellers. That was the basement of analysis by the retrospective method. This data was compared with such sources: late 19 c.-early 20 c. guidebooks and middle 19 c. maps with their accompaniment notes.The administrative units’ division of Lviv’s territory was applied in this article because during the long 19 century Lviv was a part of Austro-Hungary Empire. That’s why 4 groups of horonyms were excluded: 1. the names of the former city’s villages that are currently preserved as the city’s horonyms because those villages were absorbed into the city only during 20th century. (Today names of those former villages do not reflect the administrative units’ division); 2. village Sygnivka, which was founded only in the 20th years of 19thcentury on the area of the former suburb Halytskie of Lviv’s early modern period; 3. the names of villages, which surrounded town’s area, but were not under the rule of the town hall; 4. all names of objects, which were upon the area of these villages.So after the exclusion, we have 48 names (horonyms). The analysis showed that one name came into being in the late 20th century and eight other ones during its first half. Fifteen horonyms, as well, as their names were founded during the 19th century. So, that leaves us with twenty-four names, which were established during the earlier period and are being used now in the city. We need to continue research on a retrospective comparison of the named recorded in the early modern serial sources.
Optimasi Pati-Alginat sebagai Bahan Pengkapsul Bakteri Probiotik terhadap Karakteristik Beads
Authors: Miskiyah Miskiyah , Juniawati Juniawati , Widaningrum Widaningrum 
Published: February 2020

Enkapsulasi merupakan proses pembungkusan (coating) suatu bahan inti dengan menggunakan bahan pengkapsul tertentu. Pemanfaatan maltodekstrin, pati sagu, dan maizena sebagai bahan pengkapsul probiotik belum banyak dikembangkan sehingga dapat dijadikan kandidat bahan pengkapsul baru. Tujuan penelitian ini adalah untuk menentukan perbandingan konsentrasi pati-alginat terbaik yang dapat digunakan untuk enkapsulasi probiotik. Rancangan percobaan yang digunakan adalah rancangan faktorial menggunakan 2 faktor, yaitu jenis bahan pengkapsul dan perbandingan konsentrasi bahan pengkapsul. Faktor jenis bahan pengkasul terdiri dari 3 taraf yaitu maltodekstrin-alginat, pati sagu-alginat, dan maizena-alginat, sedangkan faktor konsentrasi bahan pengkapsul terdiri dari 3 taraf yaitu 1:1; 1:2; dan 1:3 (b/b). Hasil penelitian menunjukkan bahwa perbandingan pati-alginat secara bervariasi menghasilkan karakteristik beads dari segi rendemen, diameter beads, dan bentuk beads yang spesifik. Kesimpulannya, bahan pengkapsul probiotik yang terbaik yaitu perbandingan pati:alginat sebesar 1:3.Optimation Starch-alginate for Probiotic Bacteria Encapsulant Based on Beads Characteristic Abstract Encapsulation was known as process of coating a core material using specific materials. The use of maltodextrin, sago starch, and corn starch as a probiotic material for encapsulation has not been widely developed as new material. The aim of the study was to determine the best ratio of starch-alginate concentrations. The experimental design used was factorial design using 2 factors, namely the type of material and the ratio of the concentration. The type of material for encapsulation consisted of: maltodextrin-alginate, sago-alginate starch, and corn starch-alginate, while the concentration was 1:1, 1:2, and 1:3 (w/w). The results showed that the varioys types of materials and concentration provided specific beads characteristic, i.e. yield, beads diameter, and beads shape. As conclusion, the optimum ratio of starch-alginate as probiotic encapsulating could be determined at a ratio of 1:3.