bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bounded Futures: Growing a Boundary Foreknowledge Infrastructure in Food Security Research
Authors: Cardon Vincent 
Published: March 2020

One preferred way of coping with the openness or indeterminacy of future is to elaborate ‘fictional expectations’ that enable action by defining possible outcomes. In this article, I propose to focus on the career of the impact foresight model to analyse how agro-economists combine imaginaries, narratives, data and calculative technologies addressing the long-term future of agriculture. Impact is a partial equilibrium model, which has become increasingly comprehensive. Its modular structure now enables it to interweave scenarios produced by other legitimate institutions, and to run simulations for a number of configurations of climate change and socio-economic evolutions. In this article, foresight models are taken to be material discursive devices. My argument is that their evolutions as technologies and the framing of the future they operate should not be analysed separately. Transforming radical uncertainty into controlled variability – magnitude of change, they explicitly endeavour to ‘bound’ uncertainty. But it is ‘bounded’ in a way that is highly dependent on the knowledge infrastructure upon which the models rely. Quantified modelling also makes it possible for economists to compare rival models and create alignments or negotiate zones of consensus, that is, a certain form of knowledge on the future. In the case under scrutiny, technological choices and data processing work contribute to reinforce a certain point of view – market, production and technology-oriented – on food security. Studying infrastructure and model design therefore allows a better understanding of path dependency and cognitive lock-in effects regarding the way the future is envisaged and narrated.
The significance of pigment epithelial detachment in central serous chorioretinopathy
Authors: Chronopoulos Argyrios , Kakkassery Vinodh , Strobel Marc Andre , Fornoff Luise , Hattenbach Lars-Olof 
Published: March 2020

Purpose: To investigate the significance of the presence and form of pigment epithelial detachment in the course of central serous chorioretinopathy as well as corticosteroid use as a risk in our patient cohort. Material and methods: Retrospective, single center study of central serous chorioretinopathy patients between January 2013 and January 2019 recording corticosteroid use prior to onset and presence and type of pigment epithelial detachment (flat-irregular, dome-shaped, none) in relationship to disease course. Results: We analyzed 53 eyes of 53 consecutive central serous chorioretinopathy patients treated in our department. Mean patient age was 53 ± 13 years. A flat-irregular pigment epithelial detachment was associated with either chronic or recurrent central serous chorioretinopathy, whereas the absence of a pigment epithelial detachment correlated positively with acute central serous chorioretinopathy (chi-square test, p < 0.05). Of the 53 patients, 10 reported corticosteroid use, 40 denied steroid use, and 3 patients failed to make a clear statement. Corticosteroid use was not correlated with the onset of central serous chorioretinopathy (Student’s t-test, p = 0.0001, chi-square test, p < 0.005). Conclusion: A small, flat-irregular pigment epithelial detachment could be a marker for chronic or recurrent central serous chorioretinopathy, whereas the absence of pigment epithelial detachment could favor acute central serous chorioretinopathy. Advanced imaging studies may provide more information on the exact characteristics and nature of pigment epithelial detachments. Corticosteroid use as possible disease trigger was not confirmed in this study.
The relationship between moral intelligence and organizational commitment of nurses
Authors: Khosravani Mahboobeh , Khosravani Mohammad , Borhani Fariba , Mohsenpour Mohaddeseh 
Published: March 2020

Background Organizational commitment is one of the most important elements in improving the quality of services provided by individuals and is more important in the nursing profession. Moral intelligence as the basis of ethics plays an important role related to the quality of provided care and also achieving to the community health goals. Research objectives This study was performed with aim to determine the relationship between nurse’s moral intelligence and their organizational commitment. Methods In this cross-sectional study, 176 nurses working in Arak, Iran were entered to the study by two-stage quota sampling. All of the hospitals were governmental. Data were collected by questionnaire that included three parts: demographic, Lennick and Kiel moral intelligence questionnaire, and Allen and Meyer organizational commitment questionnaire. Data were analyzed by Pearson correlation coefficient and Fisher’s exact test using SPSS17. Result There was positive correlation between moral intelligence and organizational commitment of nurses (P < 0.001, r = 0.33). Among 120 cases (86% of total) with high organizational commitment, 90 (84.2% of them) had well to high moral intelligence. Conclusion According to the positive correlation between nurses’ moral intelligence and organizational commitment, we can propose that trying to promote nurses’ moral intelligence will lead to increase the nurses’ organizational commitment and this will improve the quality of care.
“Reclaiming My Time” Amid Organizational Change: A Dialectical Approach to Support the Thriving and Career Development for Faculty at the Margins
Authors: Davis Tiffany J. , Greer Tomika W. , Sisco Stephanie , Collins Joshua C. 
Published: March 2020

The ProblemThe faculty in academia is slowly diversifying, yet individuals who identify as women, people of Color, and/or LGBTQ (lesbian, gay, bisexual, transgender, and queer/questioning) remain underrepresented. Racism, sexism, and heterosexism in the workplace, and intersections of identity and academic rank frequently marginalize women, people of Color, and LGBTQ faculty in the academy.The SolutionCritical Human Resource Development (CHRD) offers the conceptual tools necessary for institutions of higher education to engage in meaningful disruption to benefit faculty on the margins. In this article, the authors provide recommendations for organizational and systemic changes that can create new space and opportunities for marginalized faculty.The StakeholdersThe recommendations offered herein can aid academic leaders including department chairs, centers for faculty development, and faculty that have the potential to transform institutional cultures and climates.
Exploring Community-Engaged Scholarship: Insights and Questions for HRD
Authors: Morrison Emily A. 
Published: March 2020

The Problem Higher education, including human resource development (HRD) programs, faces increasing public scrutiny for being out of touch with issues and concerns facing local and global communities by guarding limited conceptualizations of scholarship. In response, colleges and universities are identifying ways to bridge the academy (higher education) with the community-at-large and looking to its faculty to weave community concerns into scholarship through means such as community-engaged scholarship (CES). While the literature on and application of CES is robust in other disciplines, it remains less widely discussed in HRD. The Solution HRD scholar-practitioners have expertise in learning, leadership, organizational culture, and change, which could benefit the larger community, but also faculty and their work. Some HRD scholar-practitioners may already be practicing CES; yet, there is limited understanding of CES within HRD despite shared values and principles, including what may be blocking community-engaged efforts. To jumpstart the discussion, this article provides an overview of CES, identifying questions and issues for HRD scholar-practitioners to consider as part of a call to action to inform and advance the practice of and scholarship on CES. The Stakeholders This article has relevance for all who seek direct and indirect ways to collaborate, integrate knowledge across disciplines and contexts (including the community at large, field of HRD, and academicians), address community concerns, and translate knowledge to serve the broader good.
Mesenchymal stem cells maintain the stemness of colon cancer stem cells via interleukin-8/mitogen-activated protein kinase signaling pathway
Authors: Ma Xiaoying , Liu Jiajun , Yang Xiaotong , Fang Kai , Zheng Peiyong , Liang Xin , Liu Jianwen 
Published: March 2020

Mesenchymal stem cells (MSCs) can act as a carrier in tumor therapy, and tumor suppressor gene-modified MSCs can reach and suppress the tumor. However, in the colon cancer microenvironment, MSCs could promote tumor growth and create the environment that is conducive to the survival of cancer stem cells (CSCs). This study discovered MSCs from three sources (bone marrow, adipose, placenta) could induce the stemness and epithelial–mesenchymal transition (EMT) of HCT116 in vitro, meanwhile adipose- and placenta-derived MSCs increase the proportion of CD133+/CD44+ HCT116. Then, we explored the interaction mechanism between CD133+/CD44+ HCT116 and MSCs by the bioinformatics and in vitro assays. After CD133+/CD44+ HCT116 were co-cultured with MSCs, many cytokines in MSCs were stimulated, including interleukin-8 (IL-8). The binding of IL-8/CXCR2 activates the downstream mitogen-activated protein kinase (MAPK) signaling pathway in colon CSCs, thereby promoting the stemness and EMT. However, inhibition of IL-8/CXCR2/Erk1/2 could reverse the effect of MSCs on CSC stemness. In addition, MSCs co-cultured with CD133+/CD44+ HCT116 produce a carcinoma-associated fibroblast phenotype via intracellular FGF10–PKA–Akt–β-catenin signaling, which can be attenuated by IL-8 peptide inhibitor. To conclude, IL-8 promotes the interaction between colon CSCs and MSCs, and activates the MAPK signaling pathway in colon CSCs, which provides a theoretical basis for the application of MSCs in clinical practice. Impact statement MSCs have the property of chemotaxis and they can migrate to the tumor site by paracrine pathway in the tumor environment, and then interact with tumor cells. Although a mass of studies have been conducted about the impact of MSCs on tumors, it is still controversial whether the exogenous MSCs promote or inhibit tumor growth. In this work, we evaluated the effects of MSCs from three sources (bone marrow, adipose, placenta) on the proliferation, stemness, and metastasis of the colon cancer cells both in vitro and in vivo. Then, we proved the IL-8/CXCR2/MAPK and FGF10–PKA–Akt–β-catenin signaling pathway which mediate the interplay between MSC and CD133+/CD44+ colon cancer cell. This research aims to provide a theoretical basis for the safe application of MSCs in the clinical treatment of colon cancer.
Apigenin Attenuates Allergic Responses of Ovalbumin-Induced Allergic Rhinitis Through Modulation of Th1/Th2 Responses in Experimental Mice
Authors: Chen Feng , He Dongyun , Yan Bailing 
Published: March 2020

Background: Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated immune-inflammatory response mainly affecting nasal mucosa. Apigenin, a flavonoid, has been documented to possess promising anti-allergic potential. Aim: To determine the potential mechanism of action of apigenin against ovalbumin (OVA)-induced AR by assessing various behavioral, biochemical, molecular, and ultrastructural modifications. Materials and Methods: Allergic rhinitis was induced in BALB/c mice (18-22 grams) by sensitizing it with OVA (5%, 500 μL, intraperitoneal [IP] on each consecutive day, for 13 days) followed by intranasal challenge with OVA (5%, 5 μL per nostril on day 21). Animals were treated with either vehicle (distilled water, 10 mg/kg, IP) or apigenin (5, 10, and 20 mg/kg, IP). Results: Intranasal challenge of OVA resulted in significant induction ( P < .05) of AR reflected by an increase in nasal symptoms (sneezing, rubbing, and discharge), which were ameliorated significantly ( P < .05) by apigenin (10 and 20 mg/kg) treatment. It also significantly inhibited ( P < .05) OVA-induced elevated serum histamine, OVA-specific IgE, total IgE, and IgG1 and β-hexosaminidase levels. Ovalbumin-induced increased levels of interleukin (IL)-4, IL-5, IL-13, and interferon (IFN)-γ in nasal lavage fluid were significantly decreased ( P < .05) by apigenin. Ovalbumin-induced alterations in splenic GATA binding protein 3 (ie, erythroid transcription factor) (GATA3), T-box protein expressed in T cells (T-bet), signal transducer and activator of transcription-6 (STAT6), suppressor of cytokine signaling 1 (SOCS1), nuclear factor-kappa B (NF-κB), and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha messenger RNA, as well as protein expressions were significantly inhibited ( P < .05) by apigenin. It also significantly ameliorated ( P < .05) nasal and spleen histopathologic and ultrastructure aberration induced by OVA. Conclusion: Apigenin regulates Th1/Th2 balance via suppression in expressions of Th2 response (IgE, histamine, ILs, GATA3, STAT6, SOCS1, and NF-κB) and activation of Th1 response (IFN-γ and T-bet) to exert its anti-allergic potential in a murine model of OVA-induced AR.
Feasibility of bile duct as venous graft for venous reconstruction in pancreatic surgery: An animal experimental study
Authors: Fan Ji-Long , Lu Cheng , Dai Xing-Long , Liu Xian , Ma Hao , Li Hai-Feng , Lin Kai , Wang Zhen , Fu Zan , Sun Yue-Ming , Miao Yi , Gao Wen-Tao 
Published: March 2020

Objective Pancreatic cancer is a kind of high malignant tumor with a poor prognosis. The aim is to determine whether the dilated bile duct can be used to reconstruct the vessels. Methods An animal model of jugular vein and portal vein reconstruction was established using the bile duct. A total of 20 landrace pigs were selected to undergo jugular vein reconstruction or portal vein reconstruction using the bile duct as a patch or bridge. The patency was evaluated by color Doppler, the reconstructed segments were removed and examined macroscopically and histologically at specified intervals, and the results were compared with synthetic vessels (IMPRA straight, 10s03-19). Results The lumen was patent, although a low level thrombosis was observed when jugular or portal vein patching was used. For bridging, stenosis of the lumen was observed, and necrosis appeared when the bile duct was used for bridging, indicating that it is feasible to reconstruct the jugular vein and portal vein with a bile duct patch. However, the bridge was not feasible possibly due to loss of blood supply, and consequent necrosis and fibrosis. Conclusion The bile duct is technically feasible, but the outcomes are unsatisfactory.
Acute hemorrhagic cerebral artery dissection: Characteristics and endovascular treatment
Authors: Lv Xianli , Yu Jianjun , Zhang Wei , Zhao Xuelian , Zhang Huifang 
Published: March 2020

Objective Acute hemorrhagic cerebral artery dissection may show a subtle stenosis and bulge on an angiogram, for which diagnosis and treatment are difficult. This report describes seven cases of acute hemorrhagic cerebral artery dissection treated by endovascular techniques. Patients and methods From January 2018 to April 2019, seven patients (22–76 years old) were diagnosed with subarachnoid hemorrhage caused by cerebral artery dissection. Six patients were treated by low-profile visualized intraluminal support stent-assisted coiling and there was a sacrifice of the posterior cerebral artery in one patient. Cerebral angiography results were obtained immediately after intervention and at follow-up. Clinical outcome was evaluated by a modified Rankin Scale score. Results Four dissections were angiographic changes of subtle stenosis and small bulges; three were apparent angiographic changes of stenosis or fusiform morphologies. All seven aneurysms were completely obliterated, a low-profile visualized intraluminal support stent was used in six patients and coil occlusion of the parent artery in one patient. Complications occurred in two cases of proximal posterior cerebral artery dissection. One bleeding complication was observed intra-procedure and one ischemic complication was observed after stent-assisted coiling. The angiographic and clinical follow-up was obtained at 3–8 months in five patients. Good recovery was achieved for six patients (modified Rankin Score 0); one patient who presented Weber syndrome caused by ischemic complication had a modified Rankin Score of two at 8 months follow-up. Conclusion Hemorrhagic cerebral artery dissection may show subtle stenosis, small bulges or fusiform morphologies on angiograms. Treatment of proximal posterior cerebral artery dissection is challenging. Endovascular reconstruction with a low-profile visualized intraluminal support stent was effective depending on the angiographic morphology.
The variability of glycated hemoglobin is associated with renal function decline in patients with type 2 diabetes
Authors: Lee Chia-Lin , Chen Cheng-Hsu , Wu Ming-Ju , Tsai Shang-Feng 
Published: March 2020

Background: The effect of glucose control, especially variability of glycated hemoglobin (HbA1c), on estimated glomerular filtration rate (eGFR) decline in type 2 diabetes is still debatable. Methods: We used tertiles of coefficient of variation (CV) to determine the variability of HbA1c (HbA1c_CV). Mixed model repeated measures (MMRM) were used to evaluate the annual eGFR decline rate. Results: In 1383 type 2 diabetic patients, we found the greater the HbA1c_CV, the greater the eGFR decline ( p = 0.01, −0.99 in low, −1.73 in mid, and −2.53 ml/min/1.73 m2/year in high HbA1c_CV). Regardless of eGFR (⩾60 or <60 ml/min/1.73 m2), the same result holds ( p = 0.019 and p = 0.007, respectively). In subgroup analysis of baseline HbA1c (%) (HbA1c < 7, 7 ⩽ HbA1c < 9, and HbA1c ⩾ 9), tertiles of HbA1c_CV showed similar effects on annual decline of eGFR ( p = 0.193, 0.300, 0.182, respectively), although a trend for a steeper decline in renal function in the highest HbA1c_CV tertile was observed for all HbA1c strata, and even for HbA1c < 7%. A similar behavior was observed in patients with macroalbuminuria or normoalbuminuria ( p = 0.219, and 0.109, respectively), with a significant trend in those with microalbuminuria ( p = 0.019). Even in patients with HbA1c < 7, high HbA1c_CV also predicts rapid eGFR decline. Before macroalbuminuria, minimizing HbA1c_CV also has renal benefit. Conclusions: HbA1c variability is an independent risk factor for deterioration of renal function. Even with well-controlled HbA1c levels (<7%), patients with high HbA1c_CV still experienced faster eGFR decline. Early minimization of glycemic variability (before macroalbuminuira) can curb deterioration of renal function. Monitoring and lowering of HbA1c_CV is highly recommended for diabetic care.
Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes
Authors: van Dijk Peter R. , Waanders Femke , Pasch Andreas , Logtenberg Susan J. J. , Vriesendorp Titia , Groenier Klaas H. , Hillebrands Jan-Luuk , Kleefstra Nanno , Gans Rijk O. B. , van Goor Harry , Bilo Henk J.G. 
Published: March 2020

Background: Serum calcification propensity can be monitored using the maturation time of calciprotein particles in serum (T50 test). A shorter T50 indicates greater propensity to calcify; this is an independent determinant of cardiovascular disease. As the intraperitoneal (IP) route of insulin administration mimics the physiology more than the subcutaneous (SC) route in persons with type 1 diabetes (T1DM), we hypothesized that IP insulin influences determinants of calcium propensity and therefore result in a longer T50 than SC insulin administration. Methods: Prospective, observational case-control study. Measurements were performed at baseline and at 26 weeks in age and gender matched persons with T1DM. Results: A total of 181 persons, 39 (21.5%) of which used IP and 142 (78.5%) SC insulin were analysed. Baseline T50 was 356 (45) minutes. The geometric mean T50 significantly differed between both treatment groups: 367 [95% confidence interval (CI) 357, 376] for the IP group and 352 (95% CI 347, 357) for the SC group with a difference of –15 (95% CI –25, –4) minutes, in favour of IP treatment. In multivariable analyses, the IP route of insulin administration had a positive relation on T50 concentrations while higher age, triglycerides and phosphate concentrations had an inverse relation. Conclusion: Among persons with T1DM, IP insulin administration results in a more favourable calcification propensity time then SC insulin. It has yet to be shown if this observation translates into improved cardiovascular outcomes.
The Impacts of Monetary and Fiscal Policies on Economic Growth in Malaysia, Singapore and Thailand
Authors: Tan Chai-Thing , Mohamed Azali , Habibullah Muzafar Shah , Chin Lee 
Published: March 2020

This article analyses the impact of monetary and fiscal policies on economic growth in Malaysia, Singapore and Thailand from 1980:Q1 to 2017:Q1. Autoregressive distributed lag (ARDL) approach is employed to determine the long-run relationship. Further, a range of econometric models, such as fully modified least squares method (FMOLS), canonical cointegration regression (CCR) and dynamic ordinary least squares method (DOLS), are applied to check the robustness. The results are stable and robust as all the models yield consistency result. The main findings in this study demonstrate that: (a) interest rate had a negative impact on economic growth in three selected countries. (b) Government spending had a negative impact on economic growth in Malaysia and Singapore, but had a positive impact in Thailand. (c) Monetary policy is more effective in Malaysia and Singapore, while fiscal policy is more effective in Thailand. JEL Classification: E52, E58, E62, C01
Suture versus screw fixation technique for tibial eminence fracture: A meta-analysis of laboratory studies
Authors: Ye Mao , Chen Jun , Hu Feng , Liu Yanxi , Tan Yang 
Published: March 2020

Purpose: The aim of this study was to compare the biomechanical properties between the suture fixation technique and the screw fixation technique for tibial eminence fracture (TEF). Methods: The current study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The PubMed, Embase, and the Cochrane were searched from inception to January 2019 comparing the suture and the screw fixation technique for TEF. The results of the eligible studies were analyzed in terms of stiffness, ultimate failure load, and displacement after the cyclic testing. Results: Six laboratory studies were included with a total of 114 knees: 57 knees were in the FiberWire suture group and 57 knees were in the single-screw group. The suture group had higher stiffness than the screw group, but there was no statistical difference between these two groups. Ultimate failure load in the suture group was statistically higher than that in the screw group. No statistically significant difference existed in displacement after the cyclic testing between the suture group and the screw group. Conclusion: The FiberWire suture fixation may be biomechanically superior to a single screw fixation in TEF treatment in mature knees regarding ultimate failure load, while no significant difference was found between the two fixations in terms of stiffness and displacement after the cyclic testing.