bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pricing VIX options with volatility clustering
Authors: Jing Bo , Li Shenghong , Ma Yong 
Published: January 2020

AbstractWe investigate the valuation of volatility index (VIX) options by developing a model with a self‐exciting Hawkes process that allows for clustering in the VIX. In the proposed framework, we find semianalytical expressions for the characteristic function and forward characteristic function, and then we solve the pricing problem of standard‐start and forward‐start options via the fast Fourier transform. The empirical results provide evidence to support the significance of accounting for volatility clustering when pricing VIX options.
Inferring information from the S&P 500, CBOE VIX, and CBOE SKEW indices
Authors: Cao Jiling , Ruan Xinfeng , Zhang Wenjun 
Published: January 2020

AbstractThis paper compares the information extracted from the S&P 500, CBOE VIX, and CBOE SKEW indices for the S&P 500 index option pricing. Based on our empirical analysis, VIX is a very informative index for option prices. Whether adding the SKEW or the VIX term structure can improve the option pricing performance depends on the model we choose. Roughly speaking, the VIX term structure is informative for some models, while the SKEW is very noisy and does not contain much important information for option prices. This paper also extends Zhang et al. (2017, J Futures Markets, 37, 211–237) into three typical affine models.
Does corporate hedging affect firm valuation? Evidence from the IPO market
Authors: Qiao Zheng , Xia Chongwu , Zhang Lei 
Published: January 2020

AbstractFocusing on the IPO market, we examine the influence of corporate hedging on firm valuation. Consistent with the argument that hedging reduces information asymmetry, we find that hedging IPO firms are associated with lower price revisions and underwriting fees. More important, hedging reduces IPO underpricing, especially for informationally opaque firms. This provides strong evidence that corporate hedging increases firm valuation. We also show that corporate hedging lowers aftermarket idiosyncratic volatility, enhances aftermarket liquidity, and improves the long‐term performance of IPO firms. We use both an instrumental variable approach and a regulation change on derivatives supply to address endogeneity concerns.
Prospective evaluation of XRCC‐1 Arg194Trp polymorphism as bio‐predictor for clinical outcome in locally advanced laryngeal cancer undergoing cisplatin‐based chemoradiation
Authors: Raturi Vijay , Hojo Hidehiro , Bhatt M. L. B. , Suhel Mohammad , Wu Chen‐Ta , Bei Yanping , Nakamura Masaki , Okumura Masayuki , Zhang Haiqin , Parmar Devendra , Badajena Avinash , Singh Rahul , Kumar Saurabh , Katiyar Tridev , Gaur Jalaj 
Published: January 2020

AbstractBackgroundTo determine X‐ray repair cross‐complementing 1 gene (XRCC‐1) Arg194Trp polymorphism as bio‐predictor for clinical outcome in advanced laryngeal squamous cell carcinoma undergoing cisplatin‐based chemoradiation (CRT).MethodsA total of 150 patients were enrolled in this prospective study. XRCC‐1 Arg194Trp genotyping categorized patients as wild (C/C) and polymorphic (C/T or T/T). The primary endpoint was to assess acute radiation‐induced toxicity (ARIT).ResultsA significant correlation of skin (P‐ .04) and oral mucosal ARIT (P‐ .01) was noticed in the XRCC‐1 polymorphic variant. A higher treatment response was noted in the polymorphic variant, and it shows a trend toward significance (P‐ .08). With 33 months of median follow‐up, 2‐year progression‐free survival (PFS) and overall survival (OS) of wild vs polymorphic variant were 34.6% vs 46.9% (P‐ .066) and 50.6% vs 62.2% (P‐ .12).ConclusionXRCC‐1 polymorphic variants have significantly higher oral mucositis and skin ARIT and may have improved trend for treatment response and PFS.
Adjuvant external beam radiotherapy for surgically resected, nonmetastatic anaplastic thyroid cancer
Authors: Saeed Nadia A. , Kelly Jacqueline R. , Deshpande Hari A. , Bhatia Aarti K. , Burtness Barbara A. , Judson Benjamin L. , Mehra Saral , Edwards Heather A. , Yarbrough Wendell G. , Peter Patricia R. , Holt Elizabeth H. , Decker Roy H. , Husain Zain A. , Park Henry S. 
Published: February 2020

AbstractBackgroundEBRT in resected, nonmetastatic anaplastic thyroid cancer (ATC) remains undefined. We evaluated patterns/outcomes with EBRT and chemotherapy in this setting.MethodsThis retrospective analysis included patients identified from the National Cancer Database with nonmetastatic ATC from 2004 to 2014 who underwent non‐palliative resection.ResultsOur analysis included 496 patients, including 375 who underwent adjuvant EBRT (among whom 198 received concurrent chemotherapy). The median age was 68 years. On MVA, EBRT was associated with sex (OR 0.5, 95% CI 0.3‐0.8, P = .002) and income (OR 2.2, 95% CI 1.4‐3.3, P < .001). EBRT was associated with longer OS on UVA (12.3 vs 9.1 months, P = .004) and MVA (HR 0.7 [CI 0.6‐0.9], P = .004). Concurrent chemoradiation was associated with longer OS on UVA (14.0 vs 9.1 months, P = .003) and MVA (HR 0.6 [CI 0.5‐0.8], P < .001).ConclusionAdjuvant EBRT is associated with longer OS in resected, nonmetastatic ATC, with additional improved survival with concurrent chemotherapy.
‘Not everybody is an internet person’: Barriers for menopause‐related health literacy among immigrant women from the Horn of Africa nations
Authors: Stanzel Karin A. , Hammarberg Karin , Fisher Jane 
Published: February 2020

AbstractIssue addressedChanges in health require new learning. There are increased risks of chronic noncommunicable diseases after menopause and positive health behaviour during the peri‐menopausal years and beyond are crucial for a healthy postmenopausal life. In order to implement health promotion messages, women require adequate health literacy skills in order to achieve better health and access to appropriate health care.MethodsThis qualitative study explored menopause‐related health literacy and experiences of menopause‐related health care using semi‐structured interviews with women from the Horn of Africa nations who had migrated to Melbourne, Australia.ResultsParticipants viewed menopause as a normal life phase and did not see the need for accessing menopause‐related information and care. Limited education, low literacy and being unfamiliar with the internet were barriers to health literacy. Participants' preferred health care providers who could converse in their first language, but regretted their lack of proactive engagement in providing menopause‐related information.ConclusionPrimary health care providers need to be aware that immigrant women from the Horn of Africa nations have poor health literacy and may be unaware of the benefits of positive health behaviours during and after menopause. Offering menopause‐related health promotion opportunistically may lead to better postmenopausal health for this group of women.So what?Health promotion and education programs codesigned with community stakeholders may be effective in engaging immigrant communities to improve menopause‐related health literacy.
Abaloparatide in Postmenopausal Women With Osteoporosis and Type 2 Diabetes: A Post Hoc Analysis of the ACTIVE Study
Authors: Dhaliwal Ruban , Hans Didier , Hattersley Gary , Mitlak Bruce , Fitzpatrick Lorraine A , Wang Yamei , Schwartz Ann V , Miller Paul D , Josse Robert G 
Published: January 2020

ABSTRACTType 2 diabetes mellitus (T2DM) increases fracture risk despite normal or increased BMD. Abaloparatide reduces fracture risk in patients with postmenopausal osteoporosis (PMO); however, its efficacy in women with T2DM is unknown. This post hoc analysis evaluated the efficacy and safety of abaloparatide in patients with T2DM. The analysis included patients with T2DM from the Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE), a phase 3, double‐blind, randomized, placebo‐ and active‐controlled trial. In ACTIVE, participants were randomized 1:1:1 to daily s.c. injections of placebo, abaloparatide (80 μg), or open‐label teriparatide (20 μg) for 18 months. A total of 198 women with PMO and T2DM from 21 centers in 10 countries were identified from ACTIVE through review of their medical records. The main outcomes measured included effect of abaloparatide versus placebo on BMD and trabecular bone score (TBS), with secondary outcomes of fracture risk and safety, in patients from ACTIVE with T2DM. Significant (p < 0.001) improvements in BMD at total hip (mean change 3.0% versus −0.4%), femoral neck (2.6% versus −0.2%), and lumbar spine (8.9% versus 1.3%) and TBS at lumbar spine (3.72% versus −0.56%) were observed with abaloparatide versus placebo at 18 months. Fracture events were fewer with abaloparatide treatment in patients with T2DM, and differences were not significant between groups except nonvertebral fractures in the abaloparatide versus placebo groups (p = 0.04). Safety was consistent with the ACTIVE population. In conclusion, in women with PMO and T2DM, abaloparatide treatment resulted in significant improvements in BMD and TBS versus placebo, consistent with the overall ACTIVE population © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
Directing group assists in transition metal‐catalyzed site‐selective C‐H bond activation/transformations
Authors: Wu Ming‐Jung , Chu Jean‐Ho 
Published: January 2020

AbstractIn the review paper, we attempt to point out the importance of the directing group in the transition metal‐catalyzed C‐H bond activation/transformations, especially in the site‐selectivity and reactivity. The employment of the directing groups in the type of reaction can enable a chemist to straightforwardly approach the desired molecular skeletons. Thus, understanding the role of the directing groups in the C‐H bond activation/transformations would benefit chemists to design better auxiliary groups and develop more efficient and practical synthetic methodologies. We believe that the synthetic strategy based on the utility of the directing group to assist in the transition metal‐catalyzed C‐H bond activation/transformations will keep playing as a mainstream role in the research field.
The Body Image Matrix of Thinness and Muscularity—Male Bodies: Development and validation of a new figure rating scale for body image in men
Authors: Arkenau Rike , Vocks Silja , Taube Christoph O. , Waldorf Manuel , Hartmann Andrea S. 
Published: January 2020

AbstractObjectiveThe study aimed to validate the Body Image Matrix of Thinness and Muscularity—Male Bodies (BIMTM‐MB), a two‐dimensional figure rating scale consisting of 64 three‐dimensional male bodies, arranged in an 8 × 8 grid, with muscularity increasing stepwise on the vertical axis and body fat on the horizontal axis.MethodThe online sample included 355 men participating in an online survey. Besides the BIMTM‐MB, participants completed questionnaires on body‐related attitudes, behaviors, and psychopathology. Another 91 men were recruited to examine test–retest reliability of the BIMTM‐MB.ResultsThe BIMTM‐MB showed good convergent and criterion validity. Men meeting their own body ideal showed higher body satisfaction and lower body‐related psychopathology. Test–retest reliability was high.ConclusionsThe BIMTM‐MB proved to be a reliable and valid measure and is recommended for use in research and clinical practice to examine central aspects of male body image.
Knockdown of Linc00052 alleviated spinal nerve ligation‐triggered neuropathic pain through regulating miR‐448 and JAK1
Authors: Wang Li , Zhu Kairun , Yang Bingyi , Cai Yi 
Published: February 2020

AbstractThe dysfunction of the nervous system contributes to neuropathic pain. Long noncoding RNAs are reported to participate in neuropathic pain. Recently, Linc00052 is implicated to be closely associated with multiple diseases. Nevertheless, the mechanisms of Linc00052 remain barely explored in neuropathic pain development. Currently, spinal nerve ligation (SNL) triggered neuropathic pain was employed in our investigation. Here, we assessed the function of Linc00052 in SNL rat models. Interestingly, we reported Linc00052 was significantly elevated in SNL rats. Loss of Linc00052 could reduce neuropathic pain progression via regulating the behaviors of neuropathic pain. Additionally, knockdown of Linc00052 repressed the processes of neuroinflammation. Interleukin (IL)‐6 and tumor necrosis factor α level were inhibited while IL‐10 was induced by the silence of Linc00052. Moreover, we predicted miR‐448 can serve as a target of Linc00052. miR‐448 exerts a crucial power in several diseases. Currently, we exhibited miR‐448 was remarkably downregulated in SNL rats. RNA immunoprecipitation experiments validated the association between miR‐448 and Linc00052. Inhibition of Linc00052 could reverse the roles of miR‐448 on neuropathic pain development. Furthermore, Janus kinase 1 (JAK1) was displayed as the putative target of miR‐448 in the present investigation. It was showed that JAK1 was induced in SNL rats. Loss of miR‐448 could dramatically induce the expression of JAK1, which was rescued by knockdown of Linc00052. Taken these together, our study implied that Linc00052 functioned as a novel target of neuropathic pain via sponging miR‐448 and regulating JAK1.
Sema3A and HIF1α co‐overexpressed iPSC‐MSCs/HA scaffold facilitates the repair of calvarial defect in a mouse model
Authors: Li Jingyi , Wang Tingting , Li Chong , Wang Zhifang , Wang Peng , Zheng Lili 
Published: February 2020

AbstractMesenchymal stem/stromal cells (MSCs) play an important role in bone tissue engineering because MSCs possess multilineage potential of differentiation to mesenchymal tissues. Semaphorin 3A (Sema3A) and hypoxia‐inducible factor‐1α (HIF1α) are proved as important regulatory factors for osteogenesis and angiogenesis. The aim of this study was to investigate the effects of Sema3A and HIF1α co‐overexpression on the osteogenesis and angiogenesis in induced pluripotent stem cell‐derived mesenchymal stem cells (iPSC‐MSCs). Importantly, we assessed the potential osteogenic effectiveness of Sema3A and HIF1α co‐overexpressed iPSC‐MSCs seeded on hydroxyapatite (HA) scaffold in a mouse calvarial defect model. The overexpression for Sema3A, HIF1α, or Sema3A‐HIF1α fusion in iPSC‐MSCs was performed by separately infecting with conducted lentiviral vector. We determined the cell proliferation, the expressions of osteogenic, and endothelial markers of iPSC‐MSCs cultured in osteogenic or endothelial induction medium in vitro. A mouse model calvarial defect was created and implanted with the Empty implant, HA scaffold alone, HA scaffold combined with iPSC‐MSCs that infected with negative control or Sema3A‐HIF1α fusion for 8 weeks in vivo. The results showed that Sema3A and HIF1α co‐overexpression reversed the reduced cell proliferation that reduced by Sema3A overexpression alone. Importantly, the co‐overexpression significantly increased the expressions of osteogenic and angiogenic related‐genes compared with negative control after induction. Moreover, the Sema3A‐HIF1α co‐overexpressed iPSC‐MSCs seeded on HA scaffold boosted the new bone and collagen fiber formation and facilitated repair of calvarial defect in a mouse model, which might have the potential application for bone defect reconstruction.
Muscle loss during primary debulking surgery and chemotherapy predicts poor survival in advanced‐stage ovarian cancer
Authors: Huang Chueh‐Yi , Yang Yuh‐Cheng , Chen Tze‐Chien , Chen Jen‐Ruei , Chen Yu‐Jen , Wu Meng‐Hao , Jan Ya‐Ting , Chang Chih‐Long , Lee Jie 
Published: January 2020

AbstractBackgroundSarcopenia is commonly observed in patients with advanced‐stage epithelial ovarian cancer (EOC). However, the effect of body composition changes—during primary debulking surgery (PDS) and adjuvant platinum‐based chemotherapy—on outcomes of patients with advanced‐stage EOC is unknown. This study aimed to evaluate the association between body composition changes and outcomes of patients with stage III EOC treated with PDS and adjuvant platinum‐based chemotherapy.MethodsPre‐treatment and post‐treatment computed tomography (CT) images of 139 patients with stage III EOC were analysed. All CT images were contrast‐enhanced scans and were acquired according to a standardized protocol. The skeletal muscle index (SMI), skeletal muscle radiodensity (SMD), and total adipose tissue index were measured using CT images obtained at the L3 vertebral level. Predictors of overall survival were identified using Cox regression models.ResultsThe median follow‐up was 37.9 months. The median duration between pre‐treatment and post‐treatment CT was 182 days (interquartile range: 161–225 days). Patients experienced an average SMI loss of 1.8%/180 days (95% confidence interval: −3.1 to −0.4; P = 0.01) and SMD loss of 1.7%/180 days (95% confidence interval: −3.3 to −0.03; P = 0.046). SMI and SMD changes were weakly correlated with body mass index changes (Spearman ρ for SMI, 0.15, P = 0.07; ρ for SMD, 0.02, P = 0.82). The modified Glasgow prognostic score was associated with SMI loss (odds ratio: 2.42, 95% confidence interval: 1.03–5.69; P = 0.04). The median time to disease recurrence was significantly shorter in patients with SMI loss ≥5% after treatment than in those with SMI loss <5% or gain (5.4 vs. 11.2 months, P = 0.01). Pre‐treatment SMI (1 cm2/m2 decrease; hazard ratio: 1.08, 95% confidence interval: 1.03–1.11; P = 0.002) and SMI change (1%/180 days decrease; hazard ratio: 1.04, 95% confidence interval: 1.01–1.08; P = 0.002) were independently associated with poorer overall survival. SMD, body mass index, and total adipose tissue index at baseline and changes were not associated with overall survival.ConclusionsSkeletal muscle index decreased significantly during treatment and was independently associated with poor overall survival in patients with stage III EOC treated with PDS and adjuvant platinum‐based chemotherapy. The modified Glasgow prognostic score might be a predictor of SMI loss during treatment.
Health knowledge of women with a fragile X premutation: Improving understanding with targeted educational material
Authors: Smolich Liana , Charen Krista , Sherman Stephanie L. 
Published: January 2020

AbstractWomen who carry a fragile X premutation are at risk for at least two major health conditions and for transmitting fragile X syndrome (FXS) to their children. The two health concerns include fragile X‐associated primary ovarian insufficiency (FXPOI) and fragile X‐associated tremor/ataxia syndrome (FXTAS). The aim of this study was to evaluate whether written educational information about these conditions would increase knowledge and facilitate communication. Women with a premutation (N = 142) completed an online pre‐test to assess their knowledge of premutation‐associated conditions, and 135 women who provided an address received a booklet titled Women's Health and the Fragile X Premutation. After 3 months, 51.1% completed the post‐test. Major gaps in knowledge were related to FXPOI and factors associated with repeat expansion. To determine whether the booklet helped to fill gaps in knowledge, we compared pre‐ and post‐test scores. Scores were significantly increased after receipt of the booklet (p < .05, Wilcoxon signed rank test). Participants answered that the booklet was ‘very helpful’ (44.6%) or ‘somewhat helpful’ (38.5%). Twenty‐four participants (34.8%) reported using the booklet to explain concepts to family members. Although we found that the booklet provided women with needed information, we found that gaps in knowledge still exist.
Treatment effect of guided tissue regeneration on the horizontal and vertical components of furcation defects: A retrospective study
Authors: Majzoub Jad , Barootchi Shayan , Tavelli Lorenzo , Wang Chin‐Wei , Travan Sunčica , Wang Hom‐Lay 
Published: February 2020

AbstractBackgroundIdentifying factors affecting the treatment outcomes of guided tissue regeneration (GTR) in furcation defects is imperative in order to obtain predictable regeneration outcomes. The aims of this study were to evaluate the clinical outcomes and survival of furcation‐involved teeth treated with GTR, and potential factors affecting the results.MethodsFurcation defects treated with GTR using an allogeneic cancellous bone graft and covered by an absorbable membrane with at least 1‐year follow‐up were selected. All data relative to the clinical outcomes were recorded. Analyses were conducted to evaluate the immediate (1‐year post‐op) clinical outcomes and the long‐term (the last assessment time) survival of the treated teeth. The effect of variables on the 1‐year post‐op clinical attachment level (CAL) changes and the tooth survival were assessed via multi‐level regression analyses and Cox Proportional‐Hazards Models.ResultsNinety‐eight treated defects were selected. The average follow‐up was 5.3 ± 4.3 years. At the 1‐year post‐surgical recall, 1.23 ± 1.48 mm CAL gain was observed (P < 0.05). The 5‐ and 10‐year survival rates of the treated teeth were 86.5% and 74.3%, respectively. The vertical component of the defect and the location of the furcation were significantly related to the post‐surgical 1‐year CAL gain, whereas membrane exposure significantly affected tooth survival.ConclusionWithin the limitations of this study, data suggests GTR using allogeneic cancellous bone graft and absorbable collagen membrane to be a viable option for treating furcation‐involved teeth if the defect morphology and the location of the defect are favorable.
Effect of the nitrification inhibitor DMPP on nitrous oxide emissions and the stabilization of ammonium following the injection of dairy slurry and digestate in a soil‐column experiment
Authors: ten Huf Martin , Olfs Hans-Werner 
Published: January 2020

AbstractInjection of slurry or digestate below maize seeds is a relatively new technique developed to improve nitrogen use efficiency. However, this practice has the major drawback of increasing nitrous oxide (N2O) emissions. The application of a nitrification inhibitor (NI) is an effective method to reduce these emissions. To evaluate the effect of the NI 3,4‐dimethypyrazole phosphate (DMPP) on N2O emissions and the stabilization of ammonium, a two‐factorial soil‐column experiment was conducted. PVC pipes (20 cm diameter and 30 cm length) were used as incubation vessels for the soil‐columns. The trial consisted of four treatments in a randomized block design with four replications: slurry injection, slurry injection + DMPP, digestate injection, and digestate injection + DMPP. During the 47‐day incubation period, N2O fluxes were measured twice a week and cumulated by linear interpolation of the gas‐fluxes of consecutive measurement dates. After completion of the gas flux measurement, concentration of ammonium and nitrate within the soil‐columns was determined. DMPP delayed the conversion of ammonium within the manure injection zone significantly. This effect was considerably more pronounced in treatment digestate + NI than in treatment slurry + NI. Regarding the cumulated N2O emissions, no difference between slurry and digestate treatments was determined. DMPP reduced the release of N2O significantly. Transferring the results into practice, the use of DMPP is a promising way to reduce greenhouse gas emissions and nitrate leaching, following the injection of slurry or digestate.