bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta‐stereotypes among women living homeless: Content, uniformity, and differences based on gender in Madrid, Spain
Authors: Vázquez José Juan , Panadero Sonia 
Published: February 2020

AbstractThis paper examines the content and degree of uniformity of meta‐stereotypes among women living homeless in Madrid, Spain, and the differences with their male counterparts. The study was conducted utilizing a structured interview with a representative sample of men living homeless (n = 158) and a convenience sample of a similar size (n = 138) of women living homeless. The results show that the meta‐stereotypes of women living homeless in Madrid are characterized by mainly negative (e.g., consumers of alcohol, drug users, lazy, criminals) or indulgent (e.g., physically and psychologically worn out, rejected by society, sick) contents, with very limited positive (e.g., courteous, respectful, polite) contents, and a high degree of uniformity. There are no major differences in the content of meta‐stereotypes of the female interviewees in terms of their age, academic background, motherhood, or nationality. Compared to men in the same situation, a larger percentage of women living homeless agree with negative and indulgent meta‐stereotypes, and a smaller percentage agree with positive meta‐stereotypes.
A 16‐mRNA signature optimizes recurrence‐free survival prediction of Stages II and III gastric cancer
Authors: Peng Ke , Chen Erbao , Li Wei , Cheng Xi , Yu Yiyi , Cui Yuehong , Li Qian , Wang Yan , Xu Xiaojing , Tang Cheng , Gan Lu , Yu Shan , Liu Tianshu 
Published: February 2020

AbstractHigh‐throughput messenger RNA (mRNA) analysis has become a powerful tool for exploring tumor recurrence or metastasis mechanisms. Here, we constructed a signature to predict the recurrence risk of Stages II and III gastric cancer (GC) patients. A least absolute shrinkage and selection operator method Cox regression model was utilized to construct the signature. Using this method, a 16‐mRNA signature was identified to be associated with the relapse‐free survival of Stages II and III GCs in training dataset GSE62254 (n = 194). Then this signature was validated in an independent Gene Expression Omnibus cohort GSE26253 (n = 297) and a dataset of The Cancer Genome Atlas (TCGA; n = 235). This classifier could successfully screen out the high‐risk Stages II and III GCs in the training cohort (hazard ratio [HR] = 40.91; 95% confidence interval [CI] = 5.58–299.7; p < .0001). Analysis in two independent validation cohorts yielded consistent results (GSE26253: HR = 1.69, 95% CI = 1.17–2.43,; p = .0045; TCGA: HR = 2.01, 95% CI = 1.13–3.56, p = .0146). Cox regression analyses revealed that the risk score derived from this signature was an independent risk factor in Stages II and III GCs. Besides, a nomogram was constructed to serve clinical practice. Through gene set variation analysis, we found several gene sets associated with chemotherapeutic drug resistance and tumor metastasis significantly enriched in high‐risk patients. In summary, this 16‐mRNA signature can be used as a powerful tool for prognostic evaluation and help clinicians identify high‐risk patients.
Retracted: The lncRNA SNHG3 accelerates papillary thyroid carcinoma progression via the miR‐214‐3p/PSMD10 axis
Authors: Sui Guoqing , Zhang Butian , Fei Dan , Wang Hui , Guo Feng , Luo Qiang 
Published: February 2020

AbstractSmall nucleolar RNA host gene 3 (SNHG3) is a long noncoding RNA (lncRNA), which is known to promote oncogenesis in many cancers but its role in human papillary thyroid carcinoma (PTC) remains poorly understood. We therefore assessed SNHG3 expression in PTC tissues via quantitative reverse transcription polymerase chain reaction. We additionally knocked down SNHG3 in PTC cells using short‐hairpin RNAs (shRNAs) to explore its functional roles in PTC. The ability of SNHG3 to bind to specific microRNAs (miRNAs) was predicted using a bioinformatics tool, and this binding was confirmed via dual‐luciferase reporter and RNA immunoprecipitation (RIP) assays. We then used a tumor xenograft model to assess the relevance of SNHG3 in vivo. We determined SNHG3 expression to be elevated in PTC tissues relative to controls, with advanced tumor‐node‐metastasis stage and lymph node metastasis being associated with this expression. Knocking down SNHG3 significantly reduced in vitro PTC cell migration, invasion, proliferation, and colony formation, and it further slowed the growth of tumors in vivo. We found that SNHG3 could bind to miR‐214‐3p as a competing endogenous RNA (ceRNA) for this miRNA, thereby regulating proteasome 26S subunit non‐ATPase 10 (PSMD10) expression, a miR‐214‐3p target. These results thus indicate that SNHG3 is an oncogenic lncRNA in PTC, acting at least in part via the miR‐214‐3p/PSMD10 axis.
Ultrasonic accelerated efficient synthesis of aminobenzochromenes using Ag2Cr2O7 nanoparticles as a reusable heterogeneous catalyst
Authors: Ebrahimi Mitra , Abdolmohammadi Shahrzad , Kia‐Kojoori Reza 
Published: February 2020

AbstractAg2Cr2O7 nanoparticles were found to be an exceedingly effective catalyst for the mild and green synthesis of aminobenzochromenes. The reaction was performed under ultrasonic irradiation as an innocuous tool and in water as a green solvent at room temperature. This method encompasses several sustainable and economic benefits.
Synthesis, biological screening, in silico study and fingerprint applications of novel 1, 2, 4‐triazole derivatives
Authors: Khan Ghouse , Sreenivasa Swamy , Govindaiah Shivaraja , Chandramohan Vivek , Shetty P Raghurama 
Published: February 2020

AbstractA series of novel 1,2,4 triazole derivatives were synthesized by treating 4‐bromo‐2‐(4H‐1,2,4‐triazole‐3‐yl)aniline (4) with different substituted benzene sulfonyl chlorides 5(a‐f) and benzyl bromides 7(a‐e). IR, 1H‐NMR, 13C‐NMR, and mass analysis confirmed the structures of the newly synthesized compounds. All derivatives were screened for their in vitro antibacterial activity against two bacterial strains viz Escherichia coli and Staphylococcus aureus, antifungal activity against Aspergillus flavus and Candida albicans, anthelmintic activity against Pheretima posthuma and also cytotoxicity activity against MDA‐MB 231 and A375 cancer cell lines. It was found that some of the derivatives showed significant antibacterial, antifungal, anthelmintic, and cytotoxic activities when compared to respective standard drugs. Molecular docking studies have assisted the theoretical binding mode of the target molecules. Compounds were also explored for fingerprint application.
DNA damage and repair in Parkinson's disease: Recent advances and new opportunities
Authors: Gonzalez‐Hunt Claudia P. , Sanders Laurie H. 
Published: February 2020

AbstractParkinson's disease (PD) is the most common movement neurodegenerative disorder. Although our understanding of the underlying mechanisms of pathogenesis in PD has greatly expanded, this knowledge thus far has failed to translate into disease‐modifying therapies. Therefore, it is of the utmost urgency to interrogate further the multifactorial etiology of PD. DNA repair defects cause many neurodegenerative diseases. An exciting new PD research avenue is the role that DNA damage and repair may play in neuronal death. The goal of this mini‐review was to discuss the evidence for the types of DNA damage that accumulates in PD, which has provided clues for which DNA repair pathways, such as DNA double‐strand break repair, are dysfunctional. We further highlight compelling data for activation of the DNA damage response in familial and idiopathic PD. The significance of DNA damage and repair is emerging in the PD field and linking these insights to PD pathogenesis may provide new insights into PD pathophysiology and consequently lead to new therapies.
Lipid Emulsion Use in Pediatric Patients Requiring Long‐Term Parenteral Nutrition
Authors: Goulet Olivier J. , Cai Wei , Seo Jeong‐Meen 
Published: February 2020

AbstractThe ability to deliver nutrients via parenteral nutrition (PN) has markedly improved the prognosis of infants and children with intestinal failure. Technical refinements and advances in knowledge have led to the development of highly sophisticated PN solutions that are tailored to meet the needs of pediatric patients. However, children who require long‐term PN have an increased risk of complications such as catheter‐related sepsis, liver disease, and bone disease. Although the pathogenesis of intestinal failure associated liver disease (IFALD) is multifactorial, studies have identified a possible link between the dose of lipid emulsions based on soybean oil and cholestasis, shown to occur with a significantly higher frequency in patients receiving >1 g lipids/kg/d. Potential contributing factors include oxidative stress, high ω‐6 polyunsaturated fatty acid (PUFA) and phytosterol content, and relatively low α‐tocopherol levels. Lipid emulsions containing fish oil offer potential advantages compared with traditional emulsions with a high soybean oil content, such as decreased ω‐6 and increased ω‐3 PUFA concentrations, high concentrations of α‐tocopherol, and reduced phytosterol content. Studies in PN‐dependent children at risk for IFALD have shown that lipid emulsions containing fish oil reduce the risk of cholestasis and improve biochemical measures of hepatobiliary function compared with pure soybean oil emulsions. This review summarizes evidence regarding the role of lipid emulsions in the management of pediatric patients with intestinal failure requiring long‐term PN, with a particular focus on the prevention and treatment of IFALD.
Analysis of temperature‐dependent Raman spectra of minerals: Statistical approaches
Authors: Pankrushina Elizaveta A. , Kobuzov Aleksandr S. , Shchapova Yuliya V. , Votyakov Sergey L. 
Published: February 2020

AbstractThe application of statistical methods to Raman spectroscopy is due to the need to analyse arrays of poorly resolved mineral spectra having low symmetry, large unit cells, and so forth. For the diagnosis of spectral changes under the influence of an external factor, as well as for the determination of critical values, statistical methods for the treatment of the spectrum profile provide more accuracy than a peak‐fitting procedure. The following algorithms for calculating statistical ξ parameters are used to parameterise I(ν,T) arrays of temperature‐dependent Raman spectra: Pearson correlation coefficient characterising the similarity/difference of signals; autocorrelation function, proposed earlier for estimating the weighted average width of spectral lines; and skewness and kurtosis, the parameters of the distribution of signal intensity. The ξ(T) relations were analysed for the synthetic and experimental spectra of natural zircon, titanite, and synthetic quartz in the range of T = 80–870 K. For zircon, the differences in the anharmonic behaviour of modes having various properties and symmetry are shown through the use of ξ(T). For quartz, at the temperatures preceding the displacive α–β phase transition, statistical analysis reveals the spectral region of soft modes, allowing their T‐behaviour to be analysed. For titanite, the critical temperature range corresponding to the displacive α–βγ phase transition is determined by differentiating ξ(T). The results show the potential of using a statistical approach for the rapid detection of spectral and temperature regions responding differently to an external effect, as well as for evaluating the critical values of an external parameter.
How rootstock/scion combinations affect watermelon fruit quality after harvest?
Authors: Fallik Elazar , Ziv Carmit 
Published: February 2020

AbstractGrafting of vegetable seedlings is a unique horticultural technology, practiced for more than five decades, aiming to overcome problems associated with intensive cultivation on limited arable land. Grafting can protect vegetables against soil‐borne diseases and nematodes; against abiotic stresses such as high or low temperatures, salinity, drought or excessive soil‐water content; and against elevated soil concentrations of heavy metals and organic pollutants. Watermelon is one of the most popular vegetables to be grafted, and more than 90% of the plants worldwide are commercially grafted. This mini review aims to summarize the latest available information about the effects of rootstock/scion combinations with respect to enhancing or impairing watermelon fruit‐quality. A better understand of the influence of rootstock/scion compatibility or incompatibility on fruit‐quality parameters will facilitate decision‐making by growers and direct breeding programs to produce high‐quality grafted fruits in a cost‐effective manner. © 2020 Society of Chemical Industry
Application of Maillard reaction product of xylose–pea protein enzymatic hydrolysate in 3D printing
Authors: Zhou Quancheng , Wang Meng , Li Hui , Wang Sai , Sun Wanting , Chen Xuanhong , Dong Leichao , Ruan Zheng 
Published: February 2020

AbstractBACKGROUNDThis paper aims to provide a basis for the application of Maillard reaction products and ideas for 3D printing of functional food.RESULTSWe evaluated the effects of pea protein enzymatic hydrolysate–xylose Maillard reaction products (xMRPs) on the printability of 3D printing materials and the structure using various techniques. It was found that compared with the addition of enzymatic hydrolysate, the materials with xMRPs and 3D printing could significantly improve the structure, physical properties, formability of 3D printing materials and 3D print products, among which the xMRPs with 6 g of xylose had the most significant effect.CONCLUSIONSThis study has important scientific value and practical significance for the high‐valued application of Millard reaction products and the promotion of the practical application of 3D printing technology in the food industry. © 2020 Society of Chemical Industry
A homozygous missense variant of SUMF1 in the Bedouin population extends the clinical spectrum in ultrarare neonatal multiple sulfatase deficiency
Authors: Staretz‐Chacham Orna , Schlotawa Lars , Wormser Ohad , Golan‐Tripto Inbal , Birk Ohad S. , Ferreira Carlos R. , Dierks Thomas , Radhakrishnan Karthikeyan 
Published: February 2020

AbstractBackgroundMultiple sulfatase deficiency (MSD, MIM #272200) is an ultrarare congenital disorder caused by SUMF1 mutation and often misdiagnosed due to its complex clinical presentation. Impeded by a lack of natural history, knowledge gained from individual case studies forms the source for a reliable diagnosis and consultation of patients and parents.MethodsWe collected clinical records as well as genetic and metabolic test results from two MSD patients. The functional properties of a novel SUMF1 variant were analyzed after expression in a cell culture model.ResultsWe report on two MSD patients—the first neonatal type reported in Israel—both presenting with this most severe manifestation of MSD. Our patients showed uniform clinical symptoms with persistent pulmonary hypertension, hypotonia, and dysmorphism at birth. Both patients were homozygous for the same novel SUMF1 mutation (c.1043C>T, p.A348V). Functional analysis revealed that the SUMF1‐encoded variant of formylglycine‐generating enzyme is highly instable and lacks catalytic function.ConclusionThe obtained results confirm genotype‒phenotype correlation in MSD, expand the spectrum of clinical presentation and are relevant for diagnosis including the extremely rare neonatal severe type of MSD.
Vascularized pedicled bone graft from the distal radius supplied by the anterior interosseous artery for treatment of ulnar shaft nonunion: An anatomical study of cadavers and a case report
Authors: Hasegawa Hideo , Shimizu Takamasa , Omokawa Shohei , Kawamura Kenji , Sananpanich Kanit , Mahakkanukrauh Pasuk , Tanaka Yasuhito 
Published: February 2020

AbstractBackgroundA vascularized distal radius graft can be a reliable solution for the treatment of refractory ulnar nonunion. The aim of this study is to establish the anatomical basis of a vascularized bone graft pedicled by the anterior interosseous artery and report its clinical application, using cadaveric studies and a case report.MethodsFourteen fresh frozen cadaveric upper limbs were used. The branches of the anterior interosseous artery (the 2, 3 intercompartmental supraretinacular artery and the fourth extensor compartment artery) were measured at the bifurcation site. The anatomical relationship between the anterior interosseous artery and motor branches of the posterior interosseous nerve was investigated. An anterior interosseous artery pedicled bone flap was used in a 48‐year‐old woman with refractory ulnar nonunion.ResultsThere were two variations depending on whether the 2,3 intercompartmental supraretinacular artery branched off distally or proximally from the terminal motor branch of the posterior interosseous nerve. The proximal border of the graft was located at an average of 10.5 cm (range, 6.5–12.5 cm) from the distal end of the ulnar head in the distal type (57%) and 17.5 cm (range, 9.5–21.5 cm) in the proximal type (43%). In the clinical application, successfully consolidation was achieved 4 months post‐surgery. The patient had not developed any postoperative complications until the 2‐year postoperative follow‐up.ConclusionsThe anterior interosseous artery‐pedicled, vascularized distal radius bone graft would be a reliable alternative solution for the treatment of an ulnar nonunion located within the distal one‐third of the ulna.
Aporphinoid Alkaloids Derivatives as Selective Cholinesterases Inhibitors: Biological Evaluation and Docking Study
Authors: Cavallaro Valeria , Murray Ana Paula , Pungitore Carlos Rodolfo , Gutiérrez Lucas Joel 
Published: February 2020

AbstractAlzheimer's dementia is a neurodegenerative disease that affects the elderly population and causes memory impairment and cognitive deficit. Manifestation of this disease is associated to acetylcholine decrease; thus, Cholinesterase inhibition is the main therapeutic strategy for the treatment of Alzheimer's disease.In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro. Alkaloids liriodenine (3) and cassythicine (10) were the best inhibitors of both cholinesterases with IC50 values lower than 10 μM. In addition, these alkaloids demonstrated better inhibition of BChE than reference drug galantamine.In addition, some alkaloids showed selective inhibition. Laurotetatine clorhydrate (13) selectively inhibit AChE over BChE. On the contrary, pachyconfine (7) interacted more efficiently with BChE active site.Molecular modelling studies were performed in order to illustrate key interactions between most active compounds and the enzymes and to explain their selectivity. These studies reveal that the benzodioxole moiety exhibits strong interactions due to hydrogen bonds that form with the Glu201 (AChE) and Tyr440 (BChE) residues, which is reflected in the IC50 values.
One‐dimensional consolidation of soil under multistage load based on continuous drainage boundary
Authors: Tian Yi‐‐> , Wu Wenbing , Jiang Guosheng , El Naggar M. Hesham , Mei Guoxiong , Xu Meijuan , Liang Rongzhu 
Published: February 2020

SummaryIn engineering practice, a rapid loading rate can result in ground failure when the strength of soft soils is relatively low, and a multistage loading scheme is always utilized to deal with this situation. Firstly, under a multistage load and the continuous drainage boundary, an analytical solution of excess pore‐water pressure and consolidation degree is obtained by virtue of the superposition formula of excess pore‐water pressure, and a more general continuous drainage boundary under arbitrary time‐dependent load is developed. Then, a comparison with existing analytical solutions is conducted to verify the present solution. A preliminary attempt on applying the continuous drainage boundary into the finite element model is made, and the feasibility of the numerical model for the one‐dimensional consolidation under the continuous drainage boundary is verified by comparing the results calculated by FEM with that from present analytical solution. Finally, the consolidation behavior of soil is investigated in detail for different int erface parameters or loading scheme. The results show that, in land reclamation projects, a horizontal drain should be placed close to the boundary with a smaller interface parameter to improve the consolidation efficiency. The degree of consolidation is also related to the applied time‐dependent load and interface parameters.
Simulated vaginal delivery causes transients vaginal smooth muscle hypersensitivity and urethral sphincter dysfunction
Authors: Callewaert Geertje , Monteiro Carvalho Mori Da Cunha Marina Gabriela , Dewulf Karel , Albersen Maarten , Deprest Jan 
Published: February 2020

AbstractBackgroundAlthough pelvic floor dysfunction (PFD) has a multifactorial etiology, pregnancy and childbirth are considered crucial events predisposing to urinary incontinence as well as pelvic organ prolapse, which are highly prevalent. Rats are the most frequently used animal model and pudendal nerve crush (PNC) and vaginal distension (VD) are often used to mimic vaginal delivery.ObjectiveTo document the time course of events after simulated vaginal delivery (SVD) on the urethral sphincter and the vaginal smooth muscle layer.Materials and MethodsVirgin female Sprague‐Dawley rats were subjected to SVD (PNC + VD) or sham surgery and evaluated at 7, 14, 21, and 42 days after the injury. Urethral function was determined in vivo by microultrasound during cystometry and vaginal smooth muscle layer was harvested for in vitro pharmacologic investigation by isometric tension recording. Furthermore, vaginal and urethral samples were investigated by immunohistochemistry and real‐time quantitative polymerase chain reaction.ResultsMicroultrasound showed no bursting of the urethral sphincter in the SVD group at 7 days with a functional recovery starting at 14 days, and normal bursting at 21 and 42 days. Vaginal smooth muscle showed higher sensitivity to carbachol at 14 and 21 days after injury; however, at 42 days, its sensitivity decreased when compared with sham.ConclusionSVD induces urethral dysfunction and a shift in vaginal smooth muscle contractile responses to carbachol.
Design/upgrade of a transparent optical network topology resilient to the simultaneous failure of its critical nodes
Authors: Barbosa Fábio , de Sousa Amaro , Agra Agostinho 
Published: February 2020

AbstractThis paper addresses two related problems in the context of transparent optical networks. In the network design problem, the aim is to identify a set of fiber links to connect a given set of nodes. In the network upgrade problem, the aim is to identify a set of new fiber links to add to a given network topology. For a given fiber length budget, the aim in both problems is to maximize the network resilience to the simultaneous failure of its critical nodes. The resilience is evaluated by the average 2‐terminal reliability (A2TR) against a set of critical node failures and the critical nodes are the ones that minimize the A2TR of the network. So, the design/upgrade problem is a bi‐level max‐min optimization problem. Recently, a multi‐start greedy randomized heuristic was proposed for both problems. Here, we propose an alternative method based on a greedy deterministic algorithm and we provide computational results showing that the new method obtains better solutions. The results show that the resiliency difference between existing network topologies and the best network design solutions is very high but this difference can be significantly reduced by network upgrades with small fiber length budgets.