bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diet: A Source of Endocrine Disruptors
Authors: Rashid Hina , Alqahtani Saad S. , Alshahrani Saeed 
Published: October 2019

Background:Food is indispensable for human life and determines the health and wellbeing of the consumer. As food is the source of energy for humans, it also emerges as one of the most important sources of exposure to deleterious chemicals both natural and synthetic. The food exposed chemicals cause a number of detrimental health effects in humans, with endocrine disruption being of serious concern amongst these effects. Such chemicals disrupting the health of endocrine system are known as endocrine-disrupting chemicals (EDCs). The food exposed EDCs need to be identified and classified to effectuate a cautious consumption of food by all and especially by vulnerable groups.Aim:The aim of the present review was to discuss food as a source of exposure to common endocrine disruptors in humans. This review presents the occurrence and levels of some of the critical endocrine disruptors exposed through frequently consumed diets.Methods:The major source of data was PubMed, besides other relevant publications. The focus was laid on data from the last five years, however significant earlier data was also considered.Conclusion:The food as a source of endocrine disruptors to humans cannot be neglected. It is highly imperative for the consumer to recognize food as a source of EDCs and make informed choices in the consumption of food items.
Behavioral Feasibility of the Clinical Nursing Information System
Authors: Jeddi Fatemeh Rangraz , Shaeri Mehdi , Akbari Hossein , Esmaili Sohila , Farrahi Razieh 
Published: October 2019

Background:
Analysis of humanitarian issues affecting the implementation time of information systems to increase the acceptance of these systems is essential.

Objective:
The aim of this study was to assess the behavioral feasibility of the clinical nursing information system.

Methods:
An applied cross-sectional study was conducted with 348 nurses in 2015. Data were collected by face to face interviews and a questionnaire containing 33 questions, which were rated on a 5-point Likert scale. Face and content validity of the questionnaire was confirmed, and its reliability was estimated 0.90 through Cronbach's alpha coefficient. Data were analyzed using chi-square tests and t-test.

Results:
An average score of behavioral feasibility was 67.44%. The rate of supply provided for implementing the clinical nursing information system was 55.2%, which was in a semi-favorable level. The necessity of system deployment in the clinical nursing sector had the highest frequency (88.2%) and interference of redesigning structures with the current work had the lowest frequency (43.6%).

Conclusion:
The possibility of implementation of the clinical nursing information system in a behavioral dimension is at a semi-favorable level. To increase the acceptance of the system, presenting a new system as a positive change and further training of the nurses is recommended.
Spatio Temporal Variability of Rainfall Across Western Libya from 1979 to 2009
Authors: Eddenjal Ali Salem 
Published: October 2019

Aims:
To understand the links between climate variability and hydrology in
western Libya.

Background:
This study represents the first comprehensive assessment of rainfall variability
in western Libya at a regional scale.

Objective:
To assess temporal and spatial variability of rainfall in western Libya, based on
data (1979-2009) from 16 rain gauges.

Methods:
The non-parametric Mann-Kendall method and Sen’s slop estimator were used to
define changes in rainfall series and their statistical significance.

Results:
Coastal and mountainous time series showed decreasing trends at the annual, autumn,
and spring scales, with very few exceptions. Notably, winter showed increasing
trends, with the significant values of 1.94 and 0.88 mm/year at Sirt and Nalut, respectively.
Desert stations showed increasing trends, especially at the annual scale, with the greatest
significant increase on the order of 1.19 mm/year in Ghadames. For the regional rainfall
trend analysis, annual, spring and autumn rainfalls decreased in the coastal and mountainous
zones, with the highest significant decrease of 1.94 mm/year. Again, winter rainfall
showed increasing trend over the whole study domain.

Conclusion:
Although most time series showed a tendency towards more drier conditions,
most of the detected trends were statistically non-significant. This study will provide guidance
for policy makers in their future planning to mitigate the impact of drought.
Bisindolization Reaction Employing Phthalimide-N-sulfonic Acid as an Efficient Catalyst
Authors: Banari Hoda , Kiyani Hamzeh , Pourali Ali Reza 
Published: October 2019

Background:
Bis(indolyl) methanes (BIMs) have a wide spectrum of applications in biomedicine
and agriculture as well as are present in natural products. These bisheterocyclic compounds
possess vast pharmacological, including antifungal, antitubercular, anti-inflammatory, antibacterial,
anticancer, anticonvulsant, antibiotic, antiviral, antimalarial, analgesic, and antidiabetic properties.
BIMs scaffolds have also been employed as selective optical chemosensors for detection of some anions
and cations with the naked eye. Because of the importance of these bisheterocycles, various methods
have been reported for their synthesis through reaction of indole derivatives and aldehydes or ketones.
Therefore, the synthesis of BIMs through different methodologies has received widespread attention
in the field of organic synthesis and medicinal chemistry.

Objective:
In this study, the catalytic activity of phthalimide-N-sulfonic acid (PISA) as an efficient and
safe solid acidic organocatalyst toward the synthesis of BIMs derivatives in ethanol is described.

Methods:
Indole derivatives (2 mmol), aryl/heteroaryl aldehydes (1 mmol), and PISA (10 mol%) were
mixture in ethanol. The reaction mixture was stirred at room temperature for the appropriate times.
After workup and separation of catalyst, the corresponding heterocyclic products were obtained
through recrystallization from hot ethanol.

Results:
The BIMs derivatives were easily obtained via Bisindolization Reaction (BIR) of two indoles
(2-methylindole and indole) with a series of aryl and heteroaryl aldehydes. The BIR was efficiently
catalyzed at room temperature using PISA as an excellent organocatalyst under optimized reaction
conditions.

Conclusion:
The reactions were implemented in simple manner and were completed within acceptable
reaction times. The expected BIM products were obtained in satisfactory yields. The catalyst can be
recovered and reused several times in the template reaction. This approach provides the benefits of
convenience, simple operational procedure, no use of hazardous organic solvents, cheapness and ease
of preparation of catalyst.
The Role of Depression, Anxiety and Illness Characteristics on Risky Sexual Behaviour among People Living with HIV in A Malaysian Tertiary Reference Hospital
Authors: Chong Seng Choi , Ibrahim Normala , Ang Jin Kiat , Masiran Ruziana , Tan Kit-Aun , Andrew Beatrice Ng , Soh Kwong-Yan , Kumar Suresh 
Published: October 2019

Background:
People living with HIV (PLHIV) have a longer lifespan with treatment and
continue to be sexually active. To date, the extent of risky sexual behaviour among local PLHIV
and its associated factors were undetermined.

Objective:
To examine the role of depression, anxiety and illness characteristics on risky sexual
behaviour among PLHIV attending care in a Malaysian tertiary reference hospital (N= 406).

Method:
It was a cross-sectional study. Subjects were recruited by systematic random sampling.
Risky sexual behaviour was determined by using the modified National Youth Risk Behaviour Survey.
PHQ-9 and GAD-7 were used to measure the depressive and anxiety symptoms, respectively.
Chi-square test was used to examine the association between the variables. Multiple logistic regression
was used to examine the predictors of the study. A p value of less than 0.05 was considered
significant and odds ratio was used as the measure of risk association.

Results:
Our study showed that 29.3% had risky sexual behaviour. Meanwhile, 21.9% and 26.4%
had depressive and anxiety symptoms, respectively. Risky sexual behaviour was significantly associated
with age, religion, education level, duration of HIV diagnosis, depressive and anxiety symptoms.
From multivariate logistic regression, duration of HIV diagnosis and anxiety symptoms significantly
predicted risky sexual behaviour.

Conclusion:
This study highlights that a substantial number of PLHIV had risky sexual behaviour
and psychological symptoms. It is important for psychological interventions that reduce risky sexual
behaviour among PLHIV who attend treatment, especially during the early phase.
ASSESSMENT OF STUDENTS ON BIPA TEACHING MATERIALS SPECIAL MATERIALS OF AGRICULTURE
Authors: Defina Defina , Rasyid Yumna , Ridwan Sakura 
Published: October 2019

ASSESSMENT OF STUDENTS ON BIPA TEACHING MATERIALS SPECIAL MATERIALS OF AGRICULTURE Defina1), Yumna Rasyid2), Sakura Ridwan2)Institut Pertanian Bogor1) dan Universitas Negeri Jakarta2)email: defina@ipb.ac.id Abstract Every teaching and learning process needs to be evaluated. One aspect that is evaluated is teaching material that is prepared and used by the teacher. Evaluation of teaching material can be done by asking for an assessment of students (students) as users of the material. This study aims to describe the results of student evaluations of integrative and content-based Indonesian language teaching material models for specific purposes of agriculture for foreign speakers. This research is evaluative research. The evaluation used in learning is program evaluation and not learning outcomes. Respondents were 14 students of BIPA IPB Developing Country Partnership Program (KNB). Data analysis based on the feasibility evaluation category with three criteria, namely discarded, maintained with revision, and maintained. The results of the study are as follows. First, the results of student evaluations are subject to the draft teaching material in the high category, with details: draft one 4.0 (high); second draft 4.3 (high); and third draft 4.5 (very high). Secondly, the input submitted, namely the need to add a variety of listening tasks (draft first), variations in the overall form of the task (second draft), perfecting the task of listening, reading, and layout (third draft). Keywords: assessment, users, teaching materials BIPA, agriculture PENILAIAN MAHASISWA TERHADAP BAHAN AJAR BIPA MATERI KHUSUS PERTANIAN AbstrakSetiap proses belajar mengajar perlu dievaluasi. Salah satu aspek yang dievaluasi adalah materi ajar yang disusun dan digunakan oleh guru. Evaluasi materi ajar dapat dilakukan dengan meminta penilaian pemelajar (mahasiswa) sebagai pengguna dari materi tersebut. Penelitian ini bertujuan mendeskripsikan hasil penilaian mahasiswa terhadap model materi ajar bahasa Indonesia integratif dan berbasis isi untuk tujuan khusus pertanian bagi penutur asing. Penelitian ini adalah penelitian evaluatif. Evaluatif yang digunakan dalam pembelajaran adalah evaluasi program dan bukan penilaian hasil belajar. Responden adalah 14 orang mahasiswa BIPA IPB Program Kemitraan Negara Berkembang (KNB). Analisis data berdasarkan kategori evaluasi kelayakan dengan tiga kriteria, yakni dibuang, dipertahankan dengan revisi, dan dipertahankan. Hasil penelitian sebagai berikut. Pertama, hasil penilaian mahasiswa terdadap draf materi ajar pada kategori tinggi, dengan rincian: draf satu 4,0 (tinggi); draf kedua 4,3 (tinggi); dan draf ketiga 4,5 (sangat tinggi). Kedua, masukan yang disampaikan, yaitu perlu ditambahkan variasi tugas menyimak (draf kesatu), variasi bentuk tugas secara keseluruhan (draf kedua), menyempurnakan tugas menyimak, membaca, dan tata letak (draf ketiga). Kata kunci: penilaian, pengguna, materi ajar BIPA, bidang pertanian
COMPARISON OF EFFECTIVENESS OF CLUSTER MAPPING, FLOW CHARTING, AND DOUBLE/ TRIPLE ENTRY ON TEACHING WRITING SKILL
Authors: Sofeny Daniar 
Published: October 2019

The study was aimed to examine the effectiveness of three writing techniques, namely Cluster Mapping, Flow Charting, and Double/ Triple Entry in improving the students’ writing skill. The research technique used was descriptive comparative technique using a quantitative approach. It compared the equations and differences as phenomena to find what factors/ situations that can cause the occurrence of a particular event. The data collection techniques were Documentation study by taking the students’ writing product and interview by giving the question and answer while face to face between the interviewer with the respondent using a tool called interview guide. The try out was conducted to measure validity and reliability. The two ways ANOVA was conducted to test the hypotheses, two –way analysis of variance with F-test at the 5% (0.05) level of significance. The subject of this study was the fourth semester English students with a total of 22 people. The English students’ writing skill using three techniques was tobe the object under the study. The findings of the study were the average writing score of students using Cluster Mapping was 56.5, the average score of students’ writing using Flow Charting was 49.6, and the average score of students’ writing using Double/ Triple Entry was 63.0. It can be concluded that those three techniques of writing skill are effective to use but the most effective is the Double/ Triple Entry technique. Keywords: cluster mapping, flow charting, double/triple entry, writing skill Keywords: Cluster Mapping, Flow Charting, Double/ Triple Entry, Writing Skill
Pregnancy-Related Information Seeking and Sharing in the Social Media Era Among Expectant Mothers: Qualitative Study
Authors: Zhu Chengyan , Zeng Runxi , Zhang Wei , Evans Richard , He Rongrong 
Published: October 2019

BackgroundSocial media has become the most popular communication tool used by Chinese citizens, including expectant mothers. An increasing number of women have adopted various forms of social media channels, such as interactive websites, instant messaging, and mobile apps, to solve problems and obtain answers to queries during pregnancy. Although the use of the internet by pregnant women has been studied extensively worldwide, limited research exists that explores the changing social media usage habits in China, where the 1 child policy ended in 2015.ObjectiveThis study aimed to (1) present the status quo of pregnancy-related information seeking and sharing via social media among Chinese expectant mothers, (2) reveal the impact of social media usage, and (3) shed light on pregnancy-related health services delivered via social media channels.MethodsA qualitative approach was employed to examine social media usage and its consequences on pregnant women. A total of 20 women who had conceived and were at various stages of pregnancy were interviewed from July 20 to August 10, 2017. Thematic analysis was conducted on the collected data to identify patterns in usage.ResultsOverall, 80% (16/20) of participants were aged in their 20s (mean 28.5 years [SD 4.3]). All had used social media for pregnancy-related purposes. For the seeking behavior, 18 codes were merged into 4 themes, namely, gravida, fetus, delivery, and the postpartum period; whereas for sharing behaviors, 10 codes were merged into 4 themes, namely, gravida, fetus, delivery, and caretaker. Lurking, small group sharing, bad news avoidance, and cross-checking were identified as the preferred patterns for using social media. Overall, 95% (19/20) of participants reported a positive mental impact from using social media during their pregnancy.ConclusionsIt is indisputable that social media has played an increasingly important role in supporting expectant mothers in China. The specific seeking and sharing patterns identified in this study indicate that the general quality of pregnancy-related information on social media, as well as Chinese culture toward pregnancy, is improving. The new themes that merge in pregnancy-related social media use represent a shift toward safe pregnancy and the promotion of a more enjoyable pregnancy. Future prenatal care should provide further information on services related to being comfortable during pregnancy and reducing the inequality of social media–based services caused by the digital divide.
Comparison of Housing First and Traditional Homeless Service Users in Eight European Countries: Protocol for a Mixed Methods, Multi-Site Study
Authors: Greenwood Ronni Michelle , Manning Rachel M , O'Shaughnessy Branagh R , Cross Oisin , Vargas-Moniz Maria J , Auquier Pascal , Santinello Massimo , Wolf Judith R , Bokszczanin Anna , Bernad Roberto , Källmén Håkan , Spinnewijn Frederik , Ornelas José ,   HOME_EU Consortium
Published: October 2019

Background
Homeless services expend considerable resources to provide for service users’ most basic needs, such as food and shelter, but their track record for ending homelessness is disappointing. An alternative model, Housing First, reversed the order of services so that homeless individuals are offered immediate access to independent housing, with wraparound supports but no treatment or abstinence requirements. Although the evidence base for Housing First’s effectiveness in ending homelessness is robust, less is known about its effectiveness in promoting recovery.

Objective
The objective of this research is to compare rehabilitation- and recovery-related outcomes of homeless services users who are engaged in either Housing First or traditional staircase services in eight European countries: France, Ireland, Italy, the Netherlands, Poland, Portugal, Spain, and Sweden.

Methods
A mixed methods, multi-site investigation of Housing First and traditional services will compare quantitative outcomes at two time points. Key rehabilitation outcomes include stable housing and psychiatric symptoms. Key growth outcomes include community integration and acquired capabilities. Semistructured interviews will be used to examine service users’ experiences of environmental constraints and affordances on acquired capabilities to identify features of homeless services that enhance service users’ capabilities sets. Multi-level modelling will be used to test for group differences—Housing First versus traditional services—on key outcome variables. Thematic analysis will be used to understand the ways in which service users make sense of internal and external affordances and constraints on capabilities.

Results
The study is registered with the European Commission (registration number: H2020-SC6-REVINEQUAL-2016/ GA726997). Two press releases, a research report to the funding body, two peer-reviewed articles, and an e-book chapter are planned for dissemination of the final results. The project was funded from September 2016 through September 2019. Expected results will be disseminated in 2019 and 2020.

Conclusions
We will use the findings from this research to formulate recommendations for European social policy on the configuration of homeless services and the scaling up and scaling out of Housing First programs. From our findings, we will draw conclusions about the setting features that promote individuals’ exits from homelessness, rehabilitation, and recovery.

International Registered Report Identifier (IRRID)
RR1-10.2196/14584
Participant-Centered Online Active Surveillance for Adverse Events Following Vaccination in a Large Clinical Trial: Feasibility and Usability Study
Authors: Munnoch Sally-Anne , Cashman Patrick , Peel Roseanne , Attia John , Hure Alexis , Durrheim David N 
Published: October 2019

Background
Active participant monitoring of adverse events following immunization (AEFI) is a recent development to improve the speed and transparency of vaccine safety postmarketing. Vaxtracker, an online tool used to monitor vaccine safety, has successfully demonstrated its usefulness in postmarketing surveillance of newly introduced childhood vaccines. However, its use in older participants, or for monitoring patients participating in large clinical trials, has not been evaluated.

Objective
The objective of this study was to monitor AEFIs in older participants enrolled in the Australian Study for the Prevention through the Immunisation of Cardiovascular Events (AUSPICE) trial, and to evaluate the usefulness and effectiveness of Vaxtracker in this research setting.

Methods
AUSPICE is a multicenter, randomized, placebo-controlled, double-blinded trial in which participants aged 55 to 61 years were given either the pneumococcal polysaccharide vaccine (23vPPV) or 0.9% saline placebo. Vaxtracker was used to monitor AEFIs in participants in either treatment arm through the administration of two online questionnaires. A link to each questionnaire was sent to participants via email or short message service (SMS) text message 7 and 28 days following vaccination. Data were collated and analyzed in near-real time to identify any possible safety signals indicating problems with the vaccine or placebo.

Results
All 4725 AUSPICE participants were enrolled in Vaxtracker. Participant response rates for the first and final survey were 96.47% (n=4558) and 96.65% (n=4525), respectively. The online survey was completed by 90.23% (4083/4525) of Vaxtracker participants within 3 days of receiving the link. AEFIs were reported by 34.40% (805/2340) of 23vPPV recipients and 10.29% (240/2332) of placebo recipients in the 7 days following vaccination. Dominant symptoms for vaccine and placebo recipients were pain at the injection site (587/2340, 25.09%) and fatigue (103/2332, 4.42%), respectively. Females were more likely to report symptoms following vaccination with 23vPPV compared with males (433/1138, 38.05% versus 372/1202, 30.95%; P<.001).

Conclusions
Vaxtracker is an effective tool for monitoring AEFIs in the 55 to 61 years age group. Participant response rates were high for both surveys, in both treatment arms and for each method of sending the survey. This study indicates that administration of 23vPPV was well-tolerated in this cohort. Vaxtracker has successfully demonstrated its application in the monitoring of adverse events in near-real time following vaccination in people participating in a national clinical trial.

Trial Registration
Australian New Zealand Trial Registry Number (ACTRN) 12615000536561; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=368506