bluuebunny/crossref_metadata_2025_split huggingface dataset:
A grounded theory study for digital academic entrepreneurship
Authors: Toniolo Korinzia , Masiero Eleonora , Massaro Maurizio , Bagnoli Carlo 
Published: February 2020

PurposeThis research aims to investigate how digital academic entrepreneurship (AE) develops, exploring its evolution from a micro to a macro perspective and highlighting the role of intellectual capital along the process. This paper contributes to the Special Issue on digital AE, providing research and practical implications.Design/methodology/approachThis study adopts a grounded theory approach which allows exploring the “How” question of digital AE. It focuses on the case of “Strategy Innovation,” the Ca' Foscari University of Venice (Italy) spin-off.FindingsDigital AE develops and regenerates through a virtuous cycle that, while supported by digital technologies, starts from single individuals and their networks, reaches a broader ecosystem, and ends once back to individuals. This study offers insights about the social impact of academic venturing activities and provides practitioners with useful insights for the understanding of academic spin-offs activities and related opportunities.Research limitations/implicationsThis study focuses on the specific research context of “Strategy Innovation,” Ca' Foscari University of Venice (Italy) spin-off. Future research should address in-depth analyses in the exploration of how digital AE emerges and evolves in different contexts and forms.Originality/valueThis study investigates digital AE's development over time, broadly illustrating the phenomenon from a micro to a macro perspective and presenting an explicative and analytical model.
Entrepreneurial orientation and firm performance in Italian firms
Authors: Galbreath Jeremy , Lucianetti Lorenzo , Thomas Ben , Tisch Daniel 
Published: February 2020

PurposeConsidering that context is important and relying on a contingency perspective, the purpose of the study is to analyze the relationship between an entrepreneurial orientation (EO) and firm performance in one of the world's oldest economies: Italy. The contingency perspective relies on competitive strategy as a moderating variable.Design/methodology/approachUsing a mix of primary and secondary data sources, relationships are explored in a sample of 229 Italian for-profit firms. Moderated regression analysis is used for the sample and additional tests are conducted by firm size groupings.FindingsThe analysis suggests that an EO is positively associated with firm performance in the sample firms. Further, competitive strategy acts as a moderating influence: a low-cost strategy negatively influences the relationship, while a differentiation strategy positively influences the relationship. The firm size groupings do not appear to affect the results.Research limitations/implicationsThe study examines only for-profit firms in a single country, Italy; therefore, generalizability is limited. The results must be interpreted in light of these limitations.Originality/valueThis study contributes to the entrepreneurship literature by considering a relatively new international context in the EO–firm performance relationship. Further, a new contingency perspective is advanced by considering competitive strategy. In doing so, this study extends an understanding of the conditions under which an EO might be associated with firm performance.
A cross-firm analysis of corporate governance compliance and performance in Indonesia
Authors: Tanjung Miranda 
Published: February 2020

PurposeThe study aims to construct a cross-firm corporate governance index to predict firm performance. The index consists of 15 governance elements from a large sample of the Indonesian firms covering the period from 2003 to 2013.Design/methodology/approachThis study presents robust results as the findings are tested by applying the generalized method of moments (GMM) estimator to eliminate endogeneity problems and unobservable heterogeneity posed by the relationship between performance and firm-level governance practices.FindingsThe results indicate that the corporate governance index is associated with enhanced corporate financial performance. Likewise, the findings reported under the pooled ordinary least squares and GMM also indicate corporate governance sub-indexes (elements), which have significant effects on performance: whistleblower mechanism, audit quality, board of director size and blockholders.Research limitations/implicationsIn the emerging market context, this study supports the notion that active and self-regulated governance practices are appreciated by the market and, in the end, can have a positive impact on financial performance. The analysis adds to the empirical literature by providing insights into how governance provisions are being actively implemented in the micro level. With regard to weak governance practices, this study is consistent with previous studies, according to which, firms have the opportunity to use corporate governance as a way of differentiating themselves from other players in countries with poorly regulated investor protection and institutional settings.Originality/valueThis study makes a positive contribution, as it looks at the impact of Indonesia’s corporate governance compliance on the basis of a set of 15 unique governance provisions, including the findings of the positive influence of corporate governance in family business.
Police cadet general and interactional knowledge of persons with autism spectrum disorders (ASDs)
Authors: Copenhaver Allen , Denney Andrew S. , Rapp Victoria 
Published: February 2020

PurposeThe purpose of this study is to ascertain law enforcement cadet general knowledge of autism spectrum disorder (ASD) and practical knowledge in how to apply various aspects of their profession to persons with ASD.Design/methodology/approachIn total, 341 law enforcement cadet surveys administered across ten individual law enforcement cadet classes were analyzed via two individual ordinary least squares (OLS) regression models. These regression models were designed to predict changes in cadet scores on their (1) general knowledge of autism scale (i.e., general knowledge regarding autism spectrum disorder itself) and (2) interactional law enforcement knowledge of autism scale (i.e., how to apply various aspects of their job to persons with ASD).FindingsFindings show that cadets who had a stronger confidence in their ability to interact with persons who have ASD actually knew less than their counterparts with lower reported overall confidence. However, one's confidence in their ability to identify persons with ASD was associated with having better overall general knowledge of ASD itself. Similarly, the greater one's overall confidence in interacting with persons with ASD was associated with lower interactional knowledge. In each model, general autism knowledge and interactional knowledge were positively associated.Practical implicationsThe results of this study have implications for cadet and officer training on ASD as each need to be trained in both general knowledge of autism and interactional autism knowledge skills related to the job functions of being a LEO. Policy implications and directions for future research are discussed.Originality/valueThe literature is sparse on law enforcement knowledge of and interaction with persons who have ASD. As such, this study has the potential to make a strong impact on the literature regarding law enforcement and their knowledge and/or interactions with persons who have ASD.
Application of a cascading filter implemented using morphological filtering and time–frequency peak filtering for seismic signal enhancement
Authors: Liu Yanping , Yan Zhengguo 
Published: February 2020

ABSTRACTInspired by the idea of the iterative time–frequency peak filtering, which applies time–frequency peak filtering several times to improve the ability of random noise reduction, this article proposes a new cascading filter implemented using mathematic morphological filtering and the time–frequency peak filtering, which we call here morphological time–frequency peak filtering for convenience. This new method will be used mainly for seismic signal enhancement and random noise reduction in which the advantages of the morphological algorithm in processing nonlinear signals and the time–frequency peak filtering in processing nonstationary signals are utilized. Structurally, the scheme of the proposed method adopts mathematic morphological operation to first preprocess the signal and then applies the time–frequency peak filtering method to ultimately extract the valid signal. Through experiments on synthetic seismic signals and field seismic data, this paper demonstrates that the morphological time–frequency peak filtering method is superior to the time–frequency peak filtering method and its iterative form in terms of valid signal enhancement and random noise reduction.
Characteristics of diffuse large B‐cell lymphoma in patients with primary Sjögren's syndrome
Authors: Gorodetskiy Vadim Romanovich , Probatova Natalya Alexandrovna , Vasilyev Vladimir Ivanovich 
Published: February 2020

AbstractAimPatients with primary Sjögren's syndrome (pSS) have an increased risk of developing diffuse large B‐cell lymphoma (DLBCL), which is an aggressive and heterogeneous non‐Hodgkin lymphoma. This study aimed to characterize DLBCLs in patients with pSS.MethodWe identified 18 patients with DLBCL and pSS over a 22‐year period. Based on the 2016 WHO guidelines, we characterized DLBCL based on immunohistochemical tests using a broad panel of antibodies, and an Epstein‐Barr virus (EBV) test using in situ hybridization.ResultsThe median time from initial pSS symptom onset to the DLBCL diagnosis was 20.5 years and the median time from the pSS diagnosis until the DLBCL diagnosis was 14 years. After the lymphoma diagnosis, the median overall survival was 3 months (range: 0‐212 months) and the 5‐year overall survival rate was 37.5%. Thirteen DLBCLs were re‐classified as DLBCL, not otherwise specified (NOS) in nine cases; EBV‐positive DLBCL, NOS in two cases; and T‐cell/histiocyte‐rich large B‐cell lymphoma in two cases. Five cases of DLBCLs were not re‐classified because their EBV status was unknown. The Hans algorithm, which uses a combination of staining for CD10, BCL6, and MUM1, was used to classify the DLBCLs into the germinal center B‐cell (GCB) subtype for three cases and the non‐GCB subtype for nine cases.ConclusionThese results indicate that DLBCL tends to occur late in pSS cases and is mainly related to the non‐GCB subtype of DLBCL.
MiRNA‐96‐5p impacts the progression of breast cancer through targeting FOXO3
Authors: Yin Ziyi , Wang Wenyan , Qu Gengbao , Wang Lin , Wang Xiang , Pan Qin 
Published: February 2020

BackgroundBreast cancer is the most common malignant tumor in women worldwide, with a high mortality rate. MicroRNAs are small non‐coding RNAs that negatively regulate the expression of target genes by interacting with the target gene 3'‐UTR, and participate in cell differentiation, proliferation, apoptosis and metabolism. The function of miRNA‐96‐5p in the progression of breast cancer has not been reported.MethodsWe used the StarBase database to investigate the expression of miRNA‐96‐5p in breast cancer and adjacent normal tissues. FOXO3 3'‐UTR construct and luciferase reporter assays was performed for the target gene. Expression levels of miRNAs including its target were analyzed by qRT‐PCR and western blot. Cell proliferation was detected by CCK8 and colony formation, EdU assay.ResultsLuciferase reporter assays showed miRNA‐96‐5p directly targeted FOXO3. Abrogation of miRNA‐96‐5p by transfection with its inhibitors in breast cancer cells significantly suppressed miRNA‐96‐5p expression and breast cancer cells proliferation. Western blot revealed that overexpression of miRNA‐96‐5p substantially reduced FOXO3 protein expression. We used the GEPIA, UALCAN and KM‐plotter databases to investigate the expression of FOXO3 in human breast cancer and adjacent normal tissues, and its correlation with survival. In addition, we found that FOXO3 spoiled miR‐96‐5p induced breast cancer cell proliferation block effecting.ConclusionsmiRNA‐96‐5p may exert a tumor promotion role through negatively regulating tumor suppressor gene FOXO3 and promoting cell proliferation.
MiRNAs in endometrioid endometrial cancer metastatic loci derived from positive lymph nodes
Authors: Wilczynski Milosz , Senderowska Daria , Krawczyk Tomasz , Szymanska Bozena , Malinowski Andrzej 
Published: February 2020

AbstractIntroductionMicroRNAs (miRNAs) take part in tumorigenesis and show aberrant expression levels in cancerous tissues. We aimed to perform miRNA profiling of endometrioid endometrial cancer (EEC) metastatic loci derived from lymph nodes. Identification of aberrant miRNAs in positive lymph nodes could contribute to establishing new diagnostic markers and therapeutic targets.Material and methodsDuring the screening phase of the study, we performed profiling of 754 human miRNAs in endometrioid endometrial cancer tissues, microdissected metastatic loci from lymph nodes and healthy lymph nodes (Taqman Array). Selection of candidate miRNAs and subsequent validation using quantitative reverse transcription polymerase chain reaction (qRT‐PCR) in 50 tissue samples were performed.ResultsAfter the screening phase of the study, five miRNAs were selected (hsa‐miR‐18b, hsa‐miR‐148a‐5p, hsa‐miR‐204, hsa‐miR‐424, hsa‐miR‐129‐1‐3p). Validation revealed that miRNA‐204 and miRNA‐424 were highly downregulated in metastatic tissues compared with endometrial cancer samples (hsa‐miR‐204—P = .0008; hsa‐miR‐424—P = .0001). Receiver operating characteristic curves, which were constructed to compare endometrioid endometrial cancer and positive endometrioid endometrial cancer lymph nodes yielded the following area under the curves (AUCs): hsa‐miR‐204—.802 (96% confidence interval CI 0.676‐0.927), hsa‐miR‐424—.84 (95% CI 0.711‐0.969).ConclusionsCompared with primary endometrioid endometrial cancer tissue, metastatic loci derived from positive lymph nodes are characterized by profound downregulation of miRNA‐204 and miRNA‐424.
Letter: increased risk of caesarean section for women with IBD—more questions than answers. Authors' reply
Authors: Tandon Parul , Huang Vivian 
Published: February 2020

LINKED CONTENTThis article is linked to Tandon et al and Selinger papers. To view these articles, visit https://doi.org/10.1111/apt.15587 and https://doi.org/10.1111/apt.15649.
Western Australia Atropine for the Treatment of Myopia (WA‐ATOM) study: Rationale, methodology and participant baseline characteristics
Authors: Lee Samantha S.Y. , Mackey David A. , Lingham Gareth , Crewe Julie M. , Richards Michael D. , Chen Fred K. , Charng Jason , Ng Fletcher , Flitcroft Ian , Loughman James J. , Azuara‐Blanco Augusto , Logan Nicola S. , Hammond Christopher J. , Chia Audrey , Truong Tan Tai , Clark Antony 
Published: February 2020

AbstractImportanceAtropine eyedrops are a promising treatment for slowing myopia progression in East Asian children. However, its effects on children in Australia, including those of non‐Asian background, have not been well‐studied.BackgroundThe Western Australia Atropine for the Treatment of Myopia (WA‐ATOM) study aims to determine the efficacy and long‐term effects of low‐dose atropine eyedrops in myopia control. This paper describes the study rationale, methodology and participant baseline characteristics.DesignSingle‐centre, double‐masked, randomized controlled trial.ParticipantsChildren (6‐16 years) with spherical equivalent ≤−1.50 D in each eye, astigmatism ≤1.50 D and myopia progression by ≥0.50 D/year.MethodsEnrolled children were randomly assigned 2:1 to receive 0.01% atropine or placebo eyedrops. Participants are examined every 6 months during first 3 years of the study (2‐year treatment phase followed by a 1‐year washout phase), and then at a 5‐year follow‐up (2 years after the end of the washout phase).Main Outcome MeasuresAnnual progression rate of myopia and axial length, tolerability to eyedrops and incidence and severity of unwanted effects.ResultsOut of 311 children who were referred, 242 were suitable for study participation, and 153 were subsequently enrolled. The baseline characteristics of enrolled participants are presented.Conclusions and RelevanceOutcomes of the WA‐ATOM study will inform on the efficacy, tolerability, safety and long‐term effects of low‐dose atropine eyedrops in myopia control in Australian children. The impact of ocular sun exposure, iris colour and parental myopia on the efficacy of low‐dose atropine will also be assessed.
Health education decreases incidence of hand eczema in metal work apprentices: Results of a controlled intervention study
Authors: Reich Anna , Wilke Annika , Gediga Günther , Baurecht Hansjörg , Rodríguez Elke , Jakasa Ivone , Geier Johannes , Mempel Martin , Buhl Timo , Weidinger Stephan , Kezic Sanja , John Swen M. , Schön Michael P. , Brans Richard 
Published: February 2020

AbstractBackgroundMetal work apprentices (MWAs) frequently develop work‐related hand eczema (HE).ObjectivesTo evaluate the effect of health education on incidence of work‐related HE in MWAs and to assess confounding factors.Materials/methodsIn a prospective controlled intervention study, 131 MWAs received educational training on prevention of HE, whereas 172 MWAs and 118 office work apprentices served as controls. At baseline and during three yearly follow‐ups, questionnaires were completed and hands were examined. Saliva samples were collected for assessment of filaggrin (FLG) null mutations and an explorative genome‐wide association study (GWAS), and levels of various cytokines were assessed from stratum corneum samples.ResultsThe 2‐year and 3‐year incidence of HE in the metalwork control group was 20.9% and 32.6%, respectively, which was significantly higher than in the intervention group (odds ratio [OR] 2.63, 95% confidence interval [CI] 1.31 to 5.28, P < .01 and OR 3.47, 95% CI 1.88 to 6.40, P < .0001). The knowledge score was higher in unaffected MWAs (P < .05). Other factors significantly associated with developing HE in MWAs were smoking cigarettes (P < .01) and FLG mutations (P < .001). No significant associations were found regarding epidermal cytokine levels and GWAS.ConclusionsHealth education is effective in primary prevention of HE in MWAs. Individual factors should be considered in targeted counseling.
Ferroptosis: Final destination for cancer?
Authors: Ye Zeng , Liu Wensheng , Zhuo Qifeng , Hu Qiangsheng , Liu Mengqi , Sun Qiqing , Zhang Zheng , Fan Guixiong , Xu Wenyan , Ji Shunrong , Yu Xianjun , Qin Yi , Xu Xiaowu 
Published: February 2020

AbstractFerroptosis is a recently defined, non‐apoptotic, regulated cell death (RCD) process that comprises abnormal metabolism of cellular lipid oxides catalysed by iron ions or iron‐containing enzymes. In this process, a variety of inducers destroy the cell redox balance and produce a large number of lipid peroxidation products, eventually triggering cell death. However, in terms of morphology, biochemistry and genetics, ferroptosis is quite different from apoptosis, necrosis, autophagy‐dependent cell death and other RCD processes. A growing number of studies suggest that the relationship between ferroptosis and cancer is extremely complicated and that ferroptosis promises to be a novel approach for the cancer treatment. This article primarily focuses on the mechanism of ferroptosis and discusses the potential application of ferroptosis in cancer therapy.
Exposure–Response Relationship of Certolizumab Pegol and Achievement of Low Disease Activity and Remission in Patients With Rheumatoid Arthritis
Authors: Paul Stéphane , Marotte Hubert , Kavanaugh Arthur , Goupille Philippe , Kvien Tore K. , de Longueville Marc , Mulleman Denis , Sandborn William J. , Vande Casteele Niels 
Published: February 2020

Anti‐tumor necrosis factor (anti‐TNF) drugs are often prescribed for the treatment of rheumatoid arthritis (RA) and other immune‐mediated inflammatory diseases. Although this treatment has been shown to be effective in many patients, up to 40% of patients do not achieve disease control. Drug concentration in plasma may be a factor affecting the observed variability in therapeutic response. In this study, we aimed to identify the plasma concentrations of the anti‐TNF certolizumab pegol (CZP), associated with improvement in disease activity in patients with RA. Data were pooled from three randomized, controlled clinical trials with a combined total of 1,935 patients analyzed. Clinical outcomes of low disease activity (LDA) and remission were defined as Disease Activity Score in 28 joints with C‐reactive protein (DAS28(CRP)) ≤ 2.7 and < 2.3, respectively. Quartile analysis results indicated that there may be an exposure‒response relationship between CZP concentration and LDA/remission outcomes at weeks 12 and 24; the association was strongest for LDA (P < 0.05). Receiver operating characteristic (ROC) analysis showed that CZP concentrations ≥ 28.0 μg/ml at week 12, and ≥ 17.6 μg/ml at week 24, were associated with a greater likelihood of achieving LDA/remission outcomes. Although confirmatory studies are warranted to define the optimal CZP therapeutic range at weeks 12 and 24, these data indicate that CZP concentrations may be associated with improvement of disease activity.
Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway
Authors: He Hongtao , Qiao Kuangyuan , Wang Chao , Yang Wuhan , Xu Zhuo , Zhang Zhilei , Jia Yuming , Zhang Chong , Peng Li 
Published: February 2020

Hydrazinocurcumin (HZC), a synthetic derivative of curcumin (CUR), has been documented to show anticancer potential in impeding tumor growth in several cancers, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms remain unclear. This study aimed to explore the function and underlying mechanisms of HZC on HCC cells, which may involve the p38 mitogen activated protein kinase (MAPK) pathway. HZC was first purified and identified. HepG2 cells were then subjected to treatment with HZC or CUR of different concentrations and p38 MAPK signaling inhibitor (SB203580) to verify their effects on HCC cell apoptosis and proliferation. Furthermore, the functional relevance between HZC and the p38 MAPK pathway in HCC was examined. It was observed that 40 μM HZC exhibited the best pro‐apoptosis effect in HCC cells. HZC was found to inhibit HCC cell proliferation and promote apoptosis, the effect of which was stronger than 5‐fluorouracil (5‐FU). More importantly, the anti‐oncogenic effect of HZC and 5‐FU was implicated with activation of the p38 MAPK pathway. In vivo experimental results showed that HZC inhibited tumor growth more effectively than 5‐FU through the p38 MAPK pathway. These results provide evidence that HZC exerted anti‐oncogenic and pro‐apoptosis effects in HCC cells through activation of the p38 MAPK pathway.