bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iterative Decision‐making for Evaluation of Adaptations (IDEA): A decision tree for balancing adaptation, fidelity, and intervention impact
Authors: Miller Christopher J. , Wiltsey‐Stirman Shannon , Baumann Ana A. 
Published: January 2020

AbstractBackgroundEvidence‐based practices (EBPs) are frequently adapted to maximize outcomes while maintaining fidelity to core EBP elements. Many step‐by‐step frameworks for adapting EBPs have been developed, but these models may not account for common complexities in the adaptation process. In this paper, we introduce the Iterative Decision‐making for Evaluation of Adaptations (IDEA), a tool to guide adaptations that addresses these issues.Framework Design and UseAdapting EBPs requires attending to key contingencies incorporated into the IDEA, including: the need for adaptations; fidelity to core EBP elements; the timeframe in which to make adaptations; the potential to collect pilot data; key clinical and implementation outcomes; and stakeholder viewpoints. We use two examples to illustrate application of the IDEA.ConclusionsThe IDEA is a practical tool to guide EBP adaptation that incorporates important decision points and the dynamism of ongoing adaptation. Its use may help implementation scientists, clinicians, and administrators maximize EBP impact.
Utilizing broad‐based partnerships to design a precision approach to implementing evidence‐based home visiting
Authors: Haroz Emily E. , Ingalls Allison , Wadlin Joshua , Kee Crystal , Begay Marissa , Neault Nicole , Barlow Allison 
Published: January 2020

AbstractThe aim of this paper is to describe a participatory process for adapting an implementation strategy, using a precision approach, for an evidence‐based home visiting program, Family Spirit. Family Spirit serves Native American and low‐income communities nationwide. To redesign Family Spirit's implementation strategy, we used workshops (n = 5) with key stakeholders and conducted an online survey with implementers (n = 81) to identify hypothesized active ingredients and “pivot points” to guide when to tailor the program and for whom. Active ingredients identified included the relationship between the home visitor and clients, lessons ensuring child safety and healthy development, parent–child communication, and goal setting. Pivot points included whether the client is a first‐time mother who has substance abuse history, has a baby at risk for childhood obesity, and/or has sexual or reproductive health concerns. These results are informing the adaptation of Family Spirit’ implementation strategy making it more responsive to diverse families while balancing fidelity to the previously proven standard model.
Maternal obesogenic diet combined with postnatal exposure to high‐fat diet induces metabolic alterations in offspring
Authors: Bariani María V. , Correa Fernando , Domínguez Rubio Ana P.  , Marvaldi Carolina , Schander Julieta A. , Beltrame Jimena S. , Cella Maximiliano , Silberman Dafne M. , Aisemberg Julieta , Franchi Ana M. 
Published: January 2020

AbstractMaternal obesity has been shown to impact the offspring health during childhood and adult life. This study aimed to evaluate whether maternal obesity combined with postnatal exposure to an obesogenic diet could induce metabolic alterations in offspring. Female CD1 mice were fed a control diet (CD, 11.1% of energy from fat) or with a high‐fat diet (HFD, 44.3% of energy from fat) for 3 months. After weaning, pups born from control and obese mothers were fed with CD or HFD for 3 months. Both mothers and offspring were weighted weekly and several blood metabolic parameters levels were evaluated. Here, we present evidence that the offspring from mothers exposed to a HFD showed increased acetylation levels of histone 3 on lysine 9 (H3K9) in the liver at postnatal Day 1, whereas the levels of acetylation of H4K16, dimethylation of H3K27, and trimethylation of H3K9 showed no change. We also observed a higher perinatal weight and increased blood cholesterol levels when compared to the offspring on postnatal Day 1 born from CD‐fed mothers. When mice born from obese mothers were fed with HFD, we observed that they gained more weight, presented higher blood cholesterol levels, and abdominal adipose tissue than mice born to the same mothers but fed with CD. Collectively, our results point toward maternal obesity and HFD consumption as a risk factor for epigenetic changes in the liver of the offspring, higher perinatal weight, increased weight gain, and altered blood cholesterol levels.
The circular RNA aplacirc_13267 upregulates duck granulosa cell apoptosis by the apla‐miR‐1‐13/THBS1 signaling pathway
Authors: Wu Yan , Xiao Hongwei , Pi Jinsong , Zhang Hao , Pan Ailuan , Pu Yuejin , Liang Zhenhua , Shen Jie , Du Jinping 
Published: January 2020

AbstractFollicle development is a key factor that determines the reproductive performance of poultry. The existing evidence suggests that circular RNAs (circRNAs) play an important role in a variety of biological processes, especially in posttranscriptional regulation, but the regulatory mechanism of circRNAs in duck follicle development has rarely been reported. To better explore the molecular mechanism of follicle development in ducks, we sequenced and analyzed the follicular circRNAs; 4,204 circRNAs were predicted in the duck follicles. Fourteen circRNAs were differentially expressed between the white follicles and yellow follicles. The results of our studies showed that aplacirc_013267 promoted cell apoptosis in duck GCs. Moreover, a bioinformatics prediction analysis demonstrated that aplacirc_013267 was involved in a circRNA‐miRNA‐mRNA coexpression network and was observed to sponge two follicle‐related miRNAs by a luciferase activity assay. Furthermore, we found that overexpression of aplacirc_013267 significantly increased thrombospondin‐1 (THBS1) expression and downregulated granulosa cell apoptosis. The mechanistic study showed that aplacirc_013267 directly binds to and inhibits apla‐mir‐1‐13; then, aplacirc_013267 increases the expression of THBS1 and upregulates granulosa cell apoptosis. Taken together, our findings demonstrate that circRNAs have potential effects in duck ovarian follicles and that circRNAs may represent a new avenue to understand follicular development.
Expression and clinicopathological significance of lipin‐1 in human breast cancer and its association with p53 tumor suppressor gene
Authors: Dinarvand Negar , Khanahmad Hossein , Hakimian Sayyed Mohammadreza , Sheikhi Abdolkarim , Rashidi Bahman , Bakhtiari Hadi , Pourfarzam Morteza 
Published: January 2020

AbstractBreast cancer (BC) is an important cause of female cancer‐related death. It has recently been demonstrated that metabolic disorders including lipid metabolism are a hallmark of cancer cells. Lipin‐1 is an enzyme that displays phosphatidate phosphatase activity and regulates the rate‐limiting step in the pathway of triglycerides and phospholipids synthesis. The objective of this study was to evaluate lipin‐1 expression, its prognostic significance, and its correlation with p53 tumor suppressor in patients with BC. In this study, 55 pairs of fresh samples of BC and adjacent noncancerous tissue were used to analyze lipin‐1, using quantitative real‐time polymerase chain reaction and immunohistochemistry (IHC) staining. The expression of other clinicopathological variables and p53 was also examined using IHC technique. The cell migration was studied in MCF‐7 and MDA‐MB231 cells following the inhibition of lipin‐1 by propranolol. Our results show that the relative expression of lipin‐1 messenger RNA was significantly higher in BC tissues compared with the adjacent normal tissue and its inhibition reduced cell migration in cancer cells. This upregulation was negatively correlated with histological grade of tumor and p53 status (p = .001 and p = .034) respectively and positively correlated with the tumor size (p = .006). Our results also seem to indicate that the high lipin‐1 expression is related to a good prognosis in patients with BC. The expression of lipin‐1 may be considered as a novel independent prognostic factor. The inhibition of lipin‐1 may also have therapeutic significance for patients with BC. The correlation between lipin‐1 and p53 confirms the role of p53 in the regulation of lipid metabolism in cancer cells.
Simultaneous separation of nickel and copper from sulfuric acid using chelating weak base resins
Authors: Ulloa Laura , Bringas Eugenio , San‐Román Mª‐Fresnedo 
Published: January 2020

AbstractBACKGROUNDThe management of industrial spent acids containing metals to be potentially recovered for further reuse is within the scope of circular economy principles. In particular, spent sulfuric acid solutions are usually treated by precipitation technologies, which are limited by the lack of selectivity thus affecting metal reuse. In this work, acidic effluents containing nickel (≈9 g L−1), copper (≈3 g L−1) and iron (≈24 g L−1) in sulfuric acid media were treated with commercial chelating resins. Iminodiacetate (Purolite®S930Plus) and bis‐picolylamine (MTS9600®) resins were selected to perform the selective recovery of nickel and copper over iron, which is an impurity for further metal recovery by electrowinning.RESULTSUnder the selected operation conditions (pH ≈ 2), resin MTS9600® reported the best separation results with removal percentages of copper, nickel and iron of ≈80%, ≈99% and ≈10% respectively. The adsorption equilibrium of copper and nickel were described by the Langmuir (qm,Cu = 48 309 mg kgdryresin−1 and KL,Cu = 9.1 10−2 L mg−1) and Freundlich (KF,Ni = 645 (mg kgdry resin−1)(L mg−1)1/n) and nNi = 2.29) models, respectively. Kinetic experiments confirmed that copper removal is preferential and weakly influenced by the operation conditions being described by a pseudo‐first‐order model. On the contrary, nickel kinetics that followed a pseudo‐second order are strongly affected by reducing both the pH and the solid–liquid ratio.CONCLUSIONSThe promising results confirm that resin MTS9600® is an effective adsorbent for the removal of nickel and copper at strong acid conditions. More research is being conducted to analyze the resin regeneration and the selective recovery of target metals. © 2020 Society of Chemical Industry
Texture signatures of native myocardial T1 as novel imaging markers for identification of hypertrophic cardiomyopathy patients without scar
Authors: Neisius Ulf , El‐Rewaidy Hossam , Kucukseymen Selcuk , Tsao Connie W. , Mancio Jennifer , Nakamori Shiro , Manning Warren J. , Nezafat Reza 
Published: January 2020

BackgroundIn patients with suspected or known hypertrophic cardiomyopathy (HCM), late gadolinium enhancement (LGE) provides diagnostic and prognostic value. However, contraindications and long‐term retention of gadolinium have raised concern about repeated gadolinium administration in this population. Alternatively, native T1‐mapping enables identification of focal fibrosis, the substrate of LGE. However HCM‐specific heterogeneous fibrosis distribution leads to subtle T1‐maps changes that are difficult to identify.PurposeTo apply radiomic texture analysis on native T1‐maps to identify patients with a low likelihood of LGE(+), thereby reducing the number of patients exposed to gadolinium administration.Study TypeRetrospective interpretation of prospectively acquired data.SubjectsIn all, 188 (54.7 ± 14.4 years, 71% men) with suspected or known HCM.Field Strength/SequenceA 1.5T scanner; slice‐interleaved native T1‐mapping (STONE) sequence and 3D LGE after administration of 0.1 mmol/kg of gadobenate dimeglumine.AssessmentLeft ventricular LGE images were location‐matched with native T1‐maps using anatomical landmarks. Using a split‐sample validation approach, patients were randomly divided 3:1 (training/internal validation vs. test cohorts). To balance the data during training, 50% of LGE(−) slices were discarded.Statistical TestsFour sets of texture descriptors were applied to the training dataset for capture of spatially dependent and independent pixel statistics. Five texture features were sequentially selected with the best discriminatory capacity between LGE(+) and LGE(−) T1‐maps and tested using a decision tree ensemble (DTE) classifier.ResultsThe selected texture features discriminated between LGE(+) and LGE(−) T1‐maps with a c‐statistic of 0.75 (95% confidence interval [CI]: 0.70–0.80) using 10‐fold cross‐validation during internal validation in the training dataset and 0.74 (95% CI: 0.65–0.83) in the independent test dataset. The DTE classifier provided adequate labeling of all (100%) LGE(+) patients and 37% of LGE(−) patients during testing.Data ConclusionRadiomic analysis of native T1‐images can identify ~1/3 of LGE(−) patients for whom gadolinium administration can be safely avoided.Level of Evidence: 2Technical Efficacy Stage: 2J. Magn. Reson. Imaging 2020. J. Magn. Reson. Imaging 2020;52:906–919.
Effects of Therapeutic Ultrasound Applied to the Lumbar Region on Renal Function
Authors: Mengi Alper , Ozdolap Senay , Koksal Tugce , Kokturk Furuzan , Can Murat , Sarikaya Selda 
Published: January 2020

ObjectivesTherapeutic ultrasound (TUS) is one of the most commonly used modalities in low back pain treatment. The objective of this study was to determine whether TUS applied to the low back region in patients with chronic low back pain had any effect on renal function.MethodsForty patients with chronic low back pain were randomized to 2 groups by a block randomization method. Thirty‐seven patients completed the final evaluation. All patients were treated for 5 sessions per week for 3 weeks with the same physiotherapy modalities (superficial heating and transcutaneous electrical nerve stimulation) and exercise therapy; in addition to these treatments, the second group was treated with TUS for 10 minutes (frequency, 1 MHz; intensity, 1.5 W/cm2; and effective irradiation area of the transducer head, 5 cm2). The serum creatinine, serum cystatin C, 24‐hour urine creatinine, creatinine clearance, 24‐hour urine microalbumin and microprotein, urine volume, and glomerular filtration rate were measured. The patients were evaluated at baseline (day 0) and the end of the treatment (day 21).ResultsThe serum cystatin C levels were increased in both groups, but this increase was not significant (P > .05). There was no difference between the groups in the percent change in all outcome measures (P > .05).ConclusionsThis showed that TUS applied to the low back region does not affect renal function.
The kinetics of photostabilization of cyanocobalamin in liposomal preparations
Authors: Arsalan Adeel , Ahmad Iqbal , Ali Syed Abid , Qadeer Kiran , Mahmud Shaukat , Humayun Fozia , Beg Anwar Ejaz 
Published: January 2020

AbstractCyanocobalamin (B12) is a photosensitive vitamin, and its photodegradation to hydroxocobalamin (B12b) in liposomes has been investigated. The values of apparent first‐order rate constants (kobs) for the photodegradation of B12 in liposomes (nine preparations) are in the range of (0.52‐2.24) × 10–3 min–1, compared to 3.21 × 10–3 min–1 for B12 in aqueous solution (pH 5.0). The entrapment efficiency of B12 in liposomes is 26.4‐38.8%. The values of kobs show a linear relation with phosphatidylcholine (PC) content in liposomes, indicating the influence of PC in inhibiting the rate of photolysis of B12. The value of the bimolecular rate constant for photochemical interaction of B12 and PC is 0.32 M–1 min–1, indicating the stabilizing effect of PC on the photolysis of B12. The ratio of B12 stabilization in liposomal preparations is in the range 2‐6 compared to that of the unentrapped vitamin The stabilization of B12 is mediated by a photoinduced charge‐transfer B12‐PC complex that leads to the reduction of B12 to B12r, which is then oxidized to B12b that has low susceptibility to photolysis. The extent of stabilization of B12 probably depends on the degree of interaction between the two compounds under the reaction conditions, indicated by the loss of B12 fluorescence.
The Therapeutic Effects of Straw Phonation on Vocal Fatigue
Authors: Kang Jing , Xue Chao , Lou Zhewei , Scholp Austin , Zhang Yi , Jiang Jack J. 
Published: January 2020

ObjectivesStraw phonation has been investigated for its vocal warm‐up effects on healthy populations and therapeutic effects on voice patients. The purpose of this article was to determine whether it is beneficial for vocal fatigue.Study DesignProspective cohort studyMethodsTwenty‐five healthy participants were recruited into 1‐hour vocal loading tasks followed by 10‐minute vocal rest or straw phonation on 2 different days. Various parameters including phonation threshold pressure (PTP), mean airflow, closed quotient (CQ), current speaking effort level (EFFT), and laryngeal discomfort (DISC) were acquired at baseline, after vocal load, and after the intervention.ResultsIncreased PTP, EFFT, and DISC were observed after vocal load. Decreased PTP, EFFT, and DISC were then acquired after both vocal rest or straw phonation. More significant improvements were obtained in straw phonation when compared with vocal rest. Additionally, significantly increased mean flow and decreased CQ were obtained after straw phonation when compared to vocal rest.ConclusionsStraw phonation has the potential to adjust aerodynamics within the vocal tract leading to improved vocal efficiency, optimized vibration mode, and attenuated vocal fatigue. This study provided a promising treatment for vocal fatigue that could have wide clinical relevance to voice users with high voice demands.Level of Evidence4 Laryngoscope, 130:E674–E679, 2020
Effects of 10 yr of nitrogen and phosphorus fertilization on carbon and nutrient cycling in a tidal freshwater marsh
Authors: Herbert Ellen R. , Schubauer‐Berigan Joseph P. , Craft Christopher B. 
Published: January 2020

AbstractTidal freshwater marshes can protect downstream ecosystems from eutrophication by intercepting excess nutrient loads, but recent studies in salt marshes suggest nutrient loading compromises their structural and functional integrity. Here, we present data on changes in plant biomass, microbial biomass and activity, and soil chemistry from plots in a tidal freshwater marsh on the Altamaha River (GA) fertilized for 10 yr with nitrogen (+N), phosphorus (+P), or nitrogen and phosphorus (+NP). Nitrogen alone doubled aboveground biomass and enhanced microbial activity, specifically rates of potential nitrification, denitrification, and methane production measured in laboratory incubations. Phosphorus alone increased soil P and doubled microbial biomass but did not affect microbial processes. Nitrogen or P alone decreased belowground biomass and soil carbon (C) whereas +NP increased aboveground biomass, microbial biomass and N cycling, and N, P, and C assimilation and burial more than either nutrient alone. Our findings suggest differential nutrient limitation of tidal freshwater macrophytes by N and microbes by P, similar to what has been observed in salt marshes. Macrophytes outcompete microbes for P in response to long‐term N and P additions, leading to increased soil C storage through increased inputs of belowground biomass relative to N and P added singly. The susceptibility of tidal freshwater marshes to long‐term nutrient enrichment and, hence their ability to mitigate eutrophication will depend on the quantity and relative proportion of N vs. P entering estuaries and tidal wetlands.
Microplastic ingestion and diet composition of planktivorous fish
Authors: Lopes Clara , Raimundo Joana , Caetano Miguel , Garrido Susana 
Published: January 2020

AbstractPlanktivorous pelagic fish are susceptible to accumulating microplastics (MP), which have the same size range as their prey and accumulate in their feeding and spawning grounds. We analyzed stomach contents of pelagic fish (European sardine, horse mackerel, anchovy, chub mackerel, Atlantic mackerel, and bogue) from Atlanto‐Iberian waters to investigate the relationship between MP ingestion, their diet composition and select a potential bioindicator. We found significant differences between diet of the studied fish species in terms of prey type and size. MP ingestion was significantly related to diet composition. Species with diets that include smaller prey (European sardine, chub mackerel, and bogue) had lower MP concentration in the stomachs than fish depending on larger mesozooplanktonic prey. Horse mackerel had the highest proportion of larger prey (> 1000 μm) and the highest MP abundance in the stomachs, and thus are a suitable bioindicator for MP monitoring in the pelagic Iberian ecosystem.
Circulating Dendritic Cells from Celiac Disease Patients Display a Gut‐Homing Profile and are Differentially Modulated by Different Gliadin‐Derived Peptides
Authors: Escudero‐Hernández Celia , Martín Álvaro , de Pedro Andrés Rodrigo , Fernández‐Salazar Luis , Garrote José Antonio , Bernardo David , Arranz Eduardo 
Published: January 2020

ScopeCirculating dendritic cell (DC) and monocyte subsets contribute to the pool of intestinal DC and macrophages in celiac disease (CeD), an autoimmune gut disorder triggered by dietary gluten. Here, this study aims to characterize these circulating subsets in CeD and assess the effect of different gliadin‐derived peptides on conventional DC (cDC).Methods and resultsFlow cytometry profiling of peripheral blood mononuclear cells reveals a slight decrease in the proportion of plasmacytoid and type 1 cDC in gluten‐free diet (GFD)‐treated CeD patients. In comparison to healthy donors, DC and monocyte subsets from active and GFD‐treated CeD patients display an increased gut‐homing profile. Type 2 cDC (cDC2) are sorted and stimulated with the gliadin‐derived peptides 8‐mer, 19‐mer, and 33‐mer. All peptides induce cDC2 maturation, although the profile is different. While peptide 8‐mer induces a Th1/Th17 pro‐inflammatory cytokine profile in active CeD patients, cDC2 primed with peptide 33‐mer displays a higher capacity to promote gut‐homing CCR9+ expression onto autologous T‐cells.ConclusionDistinct gliadin‐derived peptides elicit different effects on cDC2 phenotype and function. This effect is compatible with a model where diverse gliadin peptides may cooperate to promote full cDC2 activation and the subsequent T‐cell response in genetically predisposed individuals.
Solvent suppression in solid‐state DNP NMR using Electronic Mixing‐Mediated Annihilation (EMMA)
Authors: Ziarelli Fabio , Thureau Pierre , Viel Stéphane , Mollica Giulia 
Published: January 2020

AbstractWe show here that the Electronic Mixing‐Mediated Annihilation (EMMA) method, previously reported for the suppression of background signals in solid‐state nuclear magnetic resonance spectra, can be successfully applied to remove the solvent signals observed in the case of nuclear magnetic resonance spectra obtained with dynamic nuclear polarization. The methodology presented here is applied to two standard sample preparation methods for dynamic nuclear polarization, namely, glass forming and incipient wetness impregnation. It is demonstrated that the Electronic Mixing‐Mediated Annihilation method is complementary to the different methods for solvent suppression based on relaxation filters and that it can be used to preserve the quantitative information that might be present in the pristine spectra.