bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Fatigue on Asymmetry Between Lower Limbs in Functional Performances in Elite Child Taekwondo Athletes
Authors: GUAN YANFEI , Bredin Shannon , Jiang Qinxian , Taunton Jack , Li Yongfeng , Wu Nana , Wu Lina , Warburton Darren 
Published: October 2020

Abstract
Background: Inter-limb asymmetry above a certain threshold in functional performance indicates increased injury risk in sports. Fatigue has been found to increase bilateral asymmetry in lower-limb jumping performance among high-school and adult athletes, whereas this impact has not been examined for child athletes. Methods: Performance of single-leg jumps, Star Excursion Balance Test (SEBT), and muscle (hamstring and gastrocnemius) flexibility were measured for 13 elite male child Taekwondo athletes (aged 9.85 ± 0.80 years) at both the rested and fatigued states to examine the inter-limb asymmetry. A two-way repeated measures ANOVA was conducted to examine for difference for each test and the interaction between limb (dominant, non-dominant leg) and state (rested, fatigued state). Paired t test or Wilcoxon Signed-Rank test was used to compare the asymmetry magnitude at the rested vs. fatigued state for each test, and the variation in performance post fatigue in the dominant vs. non-dominant leg when appropriate. Results: The inter-limb asymmetry in triple-hop distance significantly (p = 0.046) increased with fatigue, whereas the asymmetry significantly (p = 0.004) decreased with fatigue in anterior (ANT) reach distance in SEBT. A significant (p = 0.027) limb by state interaction was shown for posterolateral (PL) reach distance in SEBT, wherein a significant (p = 0.005) bilateral difference was only shown at the rested state. The PL reach distance showed a significantly greater decrease (p = 0.028) post fatigue when using the dominant leg for support compared to using the non-dominant leg.Conclusion: Fatigue significantly impacts inter-limb asymmetry in jump performances and dynamic balance for child athletes, while the variation in inter-limb asymmetry post fatigue may be different across tests. For the purpose of injury prevention, practitioners should consider assessing the inter-limb asymmetry for children at both the rested and fatigued state, and be mindful of the fatigue response of each leg in functional tests.
Identification of critical pathways and potential therapeutic targets in Poorly differentiated duodenal papilla adenocarcinoma
Authors: Lu Yuanxiang , Li Wensen , Liu Ge , Xiao Erwei , Mu Senmao , Li Deyu , Yan Guoyi 
Published: October 2020

Abstract
Background: Duodenal papilla carcinoma (DPC) is a rare malignancy of the gastrointestinal tract with high recurrence rate, and the pathogenesis of this highly malignant neoplasm is yet to be fully elucidated. This study aims to identify key genes to further understand the biology and pathogenesis underlying the molecular alterations driving DPC, which could be potential diagnostic or therapeutic targets.Methods: Tumor samples of three DPC patients were collected and integrating RNA-seq analysis of tumor tissues and matched normal tissues were performed to discover differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were carried out to understand the potential bio-functions of the DPC differentially expressed genes (DEGs) and protein–protein interaction (PPI) network was constructed for functional modules analysis and dentification of hub genes. Results: A total of 110 DEGs were identified from our RNA-Seq data, GO and KEGG analyses showed that the DEGs were mainly enriched in multiple cancer-related functions and pathways, such as cell proliferation, IL-17signaling pathway, Jak-STAT signaling pathway, PPAR signaling pathway. The PPI network screened out six hub genes including IL-6, LEP, LCN2, CCND1, FABP4 and MMP1, which were identified as core genes in the network and potential therapeutic targets of DPC. Discussion: The current study provides new insight into the exploration of DPC pathogenesis and the screened hub genes may serve as potential diagnostic indicator and novel therapeutic target.
Validation of improved 24-hour dietary recall using a portable camera among Japanese population, having large variety of food and food preparation
Authors: Matsushita Yumi , Takahashi Tosei , Asahi Kumiko , Harashima Emiko , Takahashi Hiroko , Tanaka Hiroyuki , Tsumuraya Yoshiko , Sarukura Nobuko , Furuta Masashi , Tanaka Heizo , Yokoyama Tetsuji 
Published: October 2020

Abstract
Background The collection of weighed food records (WFR) is a gold standard for dietary assessment. However, what a person eats changes every day, and it is practically difficult to weigh foods and drinks daily and calculate their nutrient contents. The validity of 24-hour dietary recall with the use of a portable camera (24hR-camera) was examined by comparison with the WFR.Methods The study subjects were recruited from 30 male adults who were fathers of university students and cooked rarely. For the validation of the 24hR-camera, we compared it and the WFR. The digital photographs were taken by the subjects of all food consumed during a day and a 24-h recall questionnaire was conducted by a registered dietitian who was trained on the survey methodology. An estimate of the amount of food consumed was made using a food atlas and the photographs taken by the subjects. For validation, comparison was made between the calculations, by both methods, of the levels of food group and nutrient. Results Correlation coefficients between the two methods were 0.7 or higher in most food groups but were low in food groups that are difficult to see, such as oils, fats, condiments, and spices. The intake of vegetables was significantly lower for the 24hR-camera method compared to the WFR method. For other food groups, except for algae, of which intake amount (in weight base) is very low, the percentages of mean difference between 24hR-camera and WFR s were -22.1% to 5.5%, with no significant differences between the methods. The correlation coefficients between the two methods were 0.774 for energy, and 0.855, 0.769, and 0.763 for the three major nutrients, proteins, lipids, and carbohydrates, respectively, demonstrating high correlation with coefficients greater than 0.75. The correlation coefficients between the two methods were 0.583 and 0.560 for salt and potassium intake, respectively, but no significant differences in intake were observed. Conclusions The method of 24-hR-canera satisfactorily estimated the intake of energy and major nutrients (except salt and potassium) in Japanese males, and was confirmed as a useful method for dietary assessment.
Effect of Liuzijue breathing exercise on patients with stable chronic obstructive pulmonary disease:a systematic review and meta-analysis
Authors: Gao Pincao , Tang Fang , Liu Weiguo , Mo Yu 
Published: October 2020

Abstract
Backgrounds:Chronic obstructive pulmonary disease(COPD) is a common,preventable disease of airflow limitation that accounts for the third leading deaths of any disease process in the worldwide. Health benefits of Liuzijue breathing exercise on patients with stable COPD has assessed. This study was designed to perform a systemic review and meta-analysis of the effect of Liuzijue breathing exercise on patients with stable COPD.Methods: Published articles from inception to 2020 were conducted using electronic searches. Two independents reviewers performed data extraction.The Cochrane risk of bias assessment tool was used to evaluate the quality of the included studies.Results:A total of 16 eligible trials with 1039 patients with stable COPD were identified. Compared with control group,the pool meta-analysis of Liuzijue breathing exercise showed a significant improve in FEV1 [MD=-0.16,95%CI (0.09,0.23), P<0.00001], FEV1% [MD=9.71, 95%CI(8.44,10.98), P<0.00001], FEV1/FVC(%) [MD=4.81,95%CI(2.12,7.51),P=0.0005],6MWD [MD=21.89,95%CI（14.67, 29.11）,P<0.00001] , health-related quality of life [SMD=-0.84,95%CI（-1.12,-0.55，P<0.00001] and mMRC [MD= -0.73,95%CI (-0.96,-0.50), P<0.00001]. The observed effect was more pronounced for interventions that were short term and medium-term duration of study. Liuzijue interventions also showed improvement in the secondary outcome measures. Conclusions:In this systematic review and meta-analysis ,Liuzijue breathing exercise can improve lung function,exercise endurance and health-related quality of life of patients with stable COPD.
Inhibition of EZH2 prevents acute respiratory distress syndrome (ARDS)-associated pulmonary fibrosis by regulating the macrophage polarization phenotype
Authors: Bao Xiaowei , Liu Xiandong , Liu Na , Zhuang Shougang , Yang Qian , Ren Huijuan , Zhao Dongyang , Bai Jianwen , Zhou Xiaohui , Tang Lunxian 
Published: October 2020

Abstract
Background: We recently reported histone methyltransferase enhancer of zeste homolog 2 (EZH2) as a key epigenetic regulator that contributes to the dysfunction of innate immune responses to sepsis and subsequent lung injury by mediating the imbalance of macrophage polarization. However, the role of EZH2 in acute respiratory distress syndrome (ARDS)-associated fibrosis remains poorly understood. Methods: In this study, we investigated the role and mechanisms of EZH2 in pulmonary fibrosis in a murine model of LPS-induced ARDS and in ex-vivo cultured alveolar macrophages (MH-S) and mouse lung epithelial cell line (MLE-12) by using 3-deazaneplanocin A (3-DZNeP) and EZH2 the small interfering (si) RNA. Results: We found that treatment with 3-DZNeP significantly ameliorated the LPS-induced direct lung injury and fibroproliferation by blocking the epithelial to mesenchymal transition (EMT) through transforming growth factor-β1 (TGF-β1)/Smad signaling pathway and regulating shift of macrophage phenotypes. In the ex-vivo polarized alveolar macrophages cells, treatment with EZH2 siRNA or 3-DZNeP suppressed the M1 while promoted the M2 macrophage differentiation through modulating the STAT/SOCS signaling pathway and activating PPAR-γ. Moreover, we identified that blockade of EZH2 with 3-DZNeP suppressed EMT in co-cultured bronchoalveolar lavage fluid (BALF) and mouse lung epithelial cell line through down-regulation of TGF-β1, TGF-βR1, Smad2 while up-regulation of Smad7 expression. Conclusions: These results indicate that EZH2 is involved in the pathological process of ARDS-associated pulmonary fibrosis. Targeting EZH2 may be a potential therapeutic strategy to prevent and treat pulmonary fibrosis post ARDS.
Concordance of Acquired Mutations between Metastatic Lesions and Liquid Biopsy in Metastatic Colorectal Cancer Treated with Anti-EGFR Therapy
Authors: Taniguchi Fumitaka , Nyuya Akihiro , Toshima Toshiaki , Mori Yoshiko , Kishimoto Hiroyuki , Umeda Yuzo , Fujiwara Toshiyoshi , Nagasaka Takeshi 
Published: October 2020

Abstract
Background: Acquired mutations are detected in circulating cell-free DNA or circulating tumor cells in blood. However, there are still few reports that examine the concordance between liquid biopsy and metastatic lesions with acquired resistance. Methods: We examined the presence of acquired mutations in 7 chemoresistant metastatic lesions and blood samples obtained from a metastatic colorectal cancer (mCRC) patient without RAS activating mutations treated with anti-EGFR treatment. The patient displayed initial early tumor shrinkage and finally progressed to disease (PD). The 7 metastatic lesions showing acquired resistance to chemotherapy were extracted at morbid autopsy. Blood samples were collected before the development of PD during first-line chemotherapy and after acquiring resistance to second- and third-line chemotherapies. Acquired mutations were analyzed using two methodologies: conventional Sanger sequencing and MEBGENTM RASKET KIT based on Luminex® technology.Results: Metastatic tumor specimens harbored diverse acquired mutations in the KRAS gene in all of the 7 (100%) metastases in the patient resistant to EGFR-targeted treatment. Of the 7 diverse acquired mutations, only one acquired mutation observed in a liver metastasis was clearly detected in the blood collected at third-line chemotherapies. Two other acquired mutations were also detected but did not reach meaningful values. Conclusions: Liquid biopsy is a successful procedure for capturing acquired mutations that may arise from progressive metastatic lesions with acquired resistance over time.
Recent Medicinal Chemistry Approach for the Development of Dipeptidyl Peptidase IV Inhibitors
Authors: Shah Bhumi M. , Modi Palmi , Trivedi Priti 
Published: October 2020

Background:
Diabetes, a metabolic disease occurs due to decrease or no effect of insulin on blood glucose level.
Current oral medication stimulates insulin release, increase glucose absorption and its utilization as well decrease hepatic
glucose output. Two major incretin hormones like Glucose dependent insulinotropic polypeptide (GIP) and glucagon like
peptide – 1 (GLP -1) stimulate insulin release after meal but their action is inhibited by enzyme dipeptidyl peptidase- IV.

Objective:
The activity of endogenous GLP-1 and GIP prolong and extend with DPP IV inhibitors which are responsible for
stimulation of insulin secretion and regulate blood glucose level. DPP IV inhibitors have shown effectiveness and endurability with neutral effect on weight as well as less chances of hypoglycemia in management of type 2 diabetes. These journeys
have been started from Sitagliptin (marketed in 2006) to Evogliptin (marketed in 2015, Korea).

Conclusion:
Treatment of type 2 diabetes includes lifestyle changes, oral medications, and insulin. Newer and superior
therapies are required than presently prescribed drugs. Various heterocyclic derivatives have been tried but due
to masking of DASH proteins, CYP enzymes and hERG channel, they showed side effects. Based on these,
study has been focused on the development of safe, influential, selective and long-lasting inhibitors of DPP IV.
Vitamin D Supplementation in Diabetic Foot Ulcers: A Current Perspective
Authors: Kurian Shilia Jacob , Miraj Sonal Sekhar , Benson Ruby , Munisamy Murali , Saravu Kavitha , Rodrigues Gabriel Sunil , Rao Mahadev 
Published: October 2020

Introduction::
Diabetic foot ulcer (DFU) is a major complication of diabetes mellitus, as
it can physically and emotionally impact the person. Its management can be challenging and expensive,
depending on the severity of the wound and the presence of infection.

Background::
The fat-soluble molecule, vitamin D, has gained great importance ever since its
pleiotropism has been recognized. Its efficacy could be attributed to the presence of vitamin D receptors
in most of the body tissues. Vitamin D plays a significant role in cell proliferation, differentiation,
and immune modulation. It modulates the T and B cells resulting in the suppression of the
immunoglobulins, autoimmunity, and inflammation.

Methods::
We performed a literature search with the objective to highlight the role of vitamin D in
peripheral vascular disease and peripheral neuropathy, which are the major risk factors for DFU, as
well as evidences of its role in wound healing and management of DFU.

Results::
Preclinical and clinical studies have shown that vitamin D influences multiple phases of
wound healing and thereby accelerates the process. It modulates various cells involved in proliferation
and remodelling phases. Vitamin D also enhances the expression of antimicrobial peptides that
help to eliminate the microbes, as well as suppress the proinflammatory responses while enhancing
the anti-inflammatory responses.

Conclusion::
This review concludes vitamin D to have a protective role in the immune and vascular
system, improve glycaemic outcomes, and wound healing. Therefore, vitamin D could be a preferred
adjuvant in the management of DFU.
Long-term echocardiography results in patients with ST-segment elevation myocardial infarction after pharmaco-invasive reperfusion therapy, depending on the choice of thrombolytic drug
Authors: Khripun A. V. , Кastanayan A. A. , Malevannyy M. V. , Kulikovskikh Ya. V. 
Published: October 2020

Objectives: to analyze the results of echocardiography 1 year after STEMI in patients undergoing pharmaco-invasive reperfusion using various thrombolytic drugs.Materials and Methods: 240 patients with STEMI after pharmaco-invasive reperfusion were included in an open-label prospective cohort study. Depending on the thrombolytic agent used, the patients were divided into 4 groups: in the 1st (n = 73) — lysis was performed with alteplase; in the 2nd (n = 40) — tenecteplase; in the 3rd (n = 95) — forteplase; in the 4th (n = 32) — streptokinase. Depending on the fibrin-specificity of the thrombolytic, all patients were presented with 2 groups: the group of fibrin-specific thrombolytics (FST, n = 208) and the group of fibrin-nonspecific streptokinase (FNST, n = 32). Echocardiography was assessed 1 year after reperfusion.Results: after 1 year, there was a slight violation of the global LV systolic function, while the EF between the groups did not differ (p = 0.420). A higher EF was recorded in the FST group compared with FNST (49.8 ± 7.4 % versus 47.4 ± 6.8 %; p = 0.048). After 1 year, violations and local LV contractility persisted in each of the four groups (p = 0.161). At the same time, lower WMSI were recorded in the FST group compared to FNST (1.19 [1.06; 1.38] versus 1.25 [1.175; 1.5]; p = 0.029). In the FST group, significantly lower iEDV were recorded (p = 0.048), and iESV (p = 0.022) and LA size (p = 0.007) compared with FNST. In dynamics, 1 year after reperfusion in the FST group, there was a significant increase in EF by 5.5 % (p = 0.000) and a decrease in LV WMSI by 5 % (p = 0.000) compared with the FNST group.Conclusions: pharmaco-invasive treatment of STEMI with the use of thrombolytic drugs after 1 year of follow-up is characterized by comparable echocardiography parameters. After 1 year of follow-up, patients undergoing pharmaco-invasive treatment with fibrin-specific drugs had significantly higher EF, as well as lower WMSI, iEDV, iESV, and LA size compared to fibrin-nonspecific streptokinase.
Scientific Publication Patterns of Mobile Technologies and Apps for Posttraumatic Stress Disorder Treatment: Bibliometric Co-Word Analysis
Authors: Kulakli Atik , Shubina Ivanna 
Published: October 2020

Background
Mobile apps are viewed as a promising opportunity to provide support for patients who have posttraumatic stress disorder (PTSD). The development of mobile technologies and apps shows similar trends in PTSD treatment. Therefore, this emerging research field has received substantial attention. Consequently, various research settings are planned for current and further studies.

Objective
The aim of this study was to explore the scientific patterns of research domains related to mobile apps and other technologies for PTSD treatment in scholarly publications, and to suggest further studies for this emerging research field.

Methods
We conducted a bibliometric analysis to identify publication patterns, most important keywords, trends for topicality, and text analysis, along with construction of a word cloud for papers published in the last decade (2010 to 2019). Research questions were formulated based on the relevant literature. In particular, we concentrated on highly ranked sources. Based on the proven bibliometric approach, the data were ultimately retrieved from the Web of Science Core Collection (Clarivate Analytics).

Results
A total of 64 studies were found concerning the research domains. The vast majority of the papers were written in the English language (63/64, 98%) with the remaining article (1/64, 2%) written in French. The articles were written by 323 authors/coauthors from 11 different countries, with the United States predominating, followed by England, Canada, Italy, the Netherlands, Australia, France, Germany, Mexico, Sweden, and Vietnam. The most common publication type was peer-reviewed journal articles (48/64, 75%), followed by reviews (8/64, 13%), meeting abstracts (5/64, 8%), news items (2/64, 3%), and a proceeding (1/64, 2%). There was a mean of 6.4 papers published per year over the study period. There was a 100% increase in the number of publications published from 2016 to 2019 with a mean of 13.33 papers published per year during this latter period.

Conclusions
Although the number of papers on mobile technologies for PTSD was quite low in the early period, there has been an overall increase in this research domain in recent years (2016-2019). Overall, these findings indicate that mobile health tools in combination with traditional treatment for mental disorders among veterans increase the efficiency of health interventions, including reducing PTSD symptoms, improving quality of life, conducting intervention evaluation, and monitoring of improvements. Mobile apps and technologies can be used as supportive tools in managing pain, anger, stress, and sleep disturbance. These findings therefore provide a useful overview of the publication trends on research domains that can inform further studies and highlight potential gaps in this field.
Identification of Semantically Similar Sentences in Clinical Notes: Iterative Intermediate Training Using Multi-Task Learning
Authors: Mahajan Diwakar , Poddar Ananya , Liang Jennifer J , Lin Yen-Ting , Prager John M , Suryanarayanan Parthasarathy , Raghavan Preethi , Tsou Ching-Huei 
Published: October 2020

Background
Although electronic health records (EHRs) have been widely adopted in health care, effective use of EHR data is often limited because of redundant information in clinical notes introduced by the use of templates and copy-paste during note generation. Thus, it is imperative to develop solutions that can condense information while retaining its value. A step in this direction is measuring the semantic similarity between clinical text snippets. To address this problem, we participated in the 2019 National NLP Clinical Challenges (n2c2)/Open Health Natural Language Processing Consortium (OHNLP) clinical semantic textual similarity (ClinicalSTS) shared task.

Objective
This study aims to improve the performance and robustness of semantic textual similarity in the clinical domain by leveraging manually labeled data from related tasks and contextualized embeddings from pretrained transformer-based language models.

Methods
The ClinicalSTS data set consists of 1642 pairs of deidentified clinical text snippets annotated in a continuous scale of 0-5, indicating degrees of semantic similarity. We developed an iterative intermediate training approach using multi-task learning (IIT-MTL), a multi-task training approach that employs iterative data set selection. We applied this process to bidirectional encoder representations from transformers on clinical text mining (ClinicalBERT), a pretrained domain-specific transformer-based language model, and fine-tuned the resulting model on the target ClinicalSTS task. We incrementally ensembled the output from applying IIT-MTL on ClinicalBERT with the output of other language models (bidirectional encoder representations from transformers for biomedical text mining [BioBERT], multi-task deep neural networks [MT-DNN], and robustly optimized BERT approach [RoBERTa]) and handcrafted features using regression-based learning algorithms. On the basis of these experiments, we adopted the top-performing configurations as our official submissions.

Results
Our system ranked first out of 87 submitted systems in the 2019 n2c2/OHNLP ClinicalSTS challenge, achieving state-of-the-art results with a Pearson correlation coefficient of 0.9010. This winning system was an ensembled model leveraging the output of IIT-MTL on ClinicalBERT with BioBERT, MT-DNN, and handcrafted medication features.

Conclusions
This study demonstrates that IIT-MTL is an effective way to leverage annotated data from related tasks to improve performance on a target task with a limited data set. This contribution opens new avenues of exploration for optimized data set selection to generate more robust and universal contextual representations of text in the clinical domain.