bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS SIMULASI DRAMA MATERI SISTEM PERNAFASAN TERHADAP HASIL BELAJAR DAN SIKAP KREATIF SISWA
Authors: Wicaksono Banu , Widiyaningrum Priyantini 
Published: December 2020

Pembelajaran simulasi drama diyakini mampu meningkatkan dan mempermudah siswa dalam mengingat suatu materi yang sulit, dan meningkatkan kreativitas. Penelitian ini bertujuan untuk menganalisis efektivitas metode simulasi drama pada materi sistem pernapasan terhadap hasil belajar dan sikap kreatif siswa SMA. Penelitian dirancang menggunakan one group pre-test post-test design. Populasi penelitian ialah seluruh kelas XI MIA SMAN 12 Semarang semester genap Tahun Ajaran 2018/2019. Sampel diambil dua kelas dengan teknik purposive sampling. Kedua kelas diberi perlakuan sama yaitu dengan menerapkan metode simulasi drama. Hasil penelitian menunjukkan bahwa ketuntasan klasikal untuk kedua kelas rata-rata 93% (kriteria sangat tinggi), nilai N-Gain berdasarkan skor pretes - postes siswa berkategori sedang, dan aktivitas siswa selama pembelajaran berkategori sangat aktif. Pembelajaran menggunakan simulasi drama juga dapat menumbuhkan sikap kreatif siswa pada kategori tinggi dan sangat tinggi. Berdasarkan analisis diatas, dapat disimpulkan bahwa simulasi drama efektif meningkatkan hasil belajar dan menumbuhkan sikap kreatif siswa.
Comprehensive assessment and scenario simulation for the future of the hydrological processes in Dez river basin, Iran
Authors: Eini Mohammad Reza , Javadi Saman , Hashemy Shahdany Mehdy , Kisi Ozgur 
Published: December 2020

Abstract
Climate change is one of the leading factors that directly affect hydrological processes in large basins. This study assesses the impacts of climate change on streamflow, sediment and crop yield, actual evapotranspiration (AET), and water budget. In addition, the effects of land use and land cover (LULC) alteration with climate change on streamflow and sediment yield have been evaluated in the Dez river basin in the southwest of Iran. Five General Circulation Models (GCMs) based on two scenarios, Representative Concentration Pathway (RCP) 4.5 and RCP 8.5 for the near period (2021–2040) are considered. Hydrological simulation is performed using the Soil and Water assessment tool (SWAT) with good performance in the calibration (1990 to 2010) and validation (2010 to 2017) periods. The precipitation and temperature projected show a major upward trend related to the base period. The results showed that climate change increases the runoff and sediments. In addition, results projected that garden crop yields would increase while agricultural crop yields would decrease. In addition, AET will face a slight decline of about 2%–6%. Combined LULC and climate change scenarios showed that with amplification of orchards areas, sediment load would decrease.
İletişimde Çözüm Odaklılık Ölçeği’nin (İÇOÖ) Geliştirilmesi, Geçerlilik ve Güvenilirliği
Authors: Şahin Ekrem Sedat , Derin Sümeyye 
Published: December 2020

Bu çalışmada, yetişkin bireylerin iletişimde çözüm odaklılık düzeyini belirlemeye yönelik, geçerli ve güvenilir bir ölçme aracı geliştirmek amaçlanmıştır. Bu amaçla çözüm odaklı yaklaşımın, iletişim diğer bir ifade ile dilin kullanımı konusuna verdiği değer incelenmiştir. İletişim, çözüm odaklı yaklaşımın merkezindedir. Çözüme yönelmede ve ulaşmada dilin kullanımı belirleyici rol oynar. Çözüm odaklı dili kullanabilmek hem günlük hayatta hem de psikolojik danışmada probleme odaklanmak yerine çözüme odaklanmayı kolaylaştırabilir. Bu nedenlerle, çalışma kapsamında oluşturulan İletişimde Çözüm Odaklılık Ölçeği’nin (İÇOÖ) geliştirilmesi sürecinde; 18 yaş ve üzerinde, elverişli/ uygun örnekleme yoluyla ulaşılan, 237 erkek ve 226 kadın; toplam 463 yetişkin birey ile çalışılmıştır. Ölçeğin geçerlilik çalışması kapsamında kaynak tarama, uzman görüşü alma, pilot uygulama ve yapı geçerliliğini inceleme gerçekleştirilmiştir. Yapı geçerliliği kapsamında 223 bireyden elde edilen veriler SPSS 23.0 Programında Açımlayıcı Faktör Analizi (AFA) ile değerlendirilmiştir. AFA sonucunda ölçeğin 17 madde ve üç faktörden oluştuğu tespit edilmiştir. AFA’nın ardından ölçek yeniden farklı bir yetişkin grubuna uygulanmıştır. Bu uygulama sonucunda 182 yetişkinin verisiyle Doğrulayıcı Faktör Analizi (DFA) gerçekleştirilmiştir. DFA’da uyum indeksi değerleri ise RMSEA= .068 CFI= .92, IFI= .92, GFI=.88, AGFI=.83 olarak bulunmuş ve DFA sonucunda ölçeğin 17 maddeli ve üç alt ölçekli yapıda, kabul edilebilir uyum değerlerine sahip olduğu tespit edilmiştir. İÇOÖ’nün güvenilirliği Cronbach Alfa (iç tutarlılık) yöntemi ile incelenmiştir. Ölçeğin hesaplanan Cronbach Alfa katsayısı .87’dir. Bu değer, ölçeğin yüksek düzeyde güvenilir bir ölçme aracı olduğunu göstermiştir. Sonuç olarak, yapılan analizler İÇOÖ’nün 18 yaş ve üzerindeki yetişkin bireylerin iletişimde çözüm odaklılıklarını belirlemek amacıyla kullanılabileceğini göstermiştir. Bulgular ilgili alanyazın ışığında tartışılmıştır.
CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models
Authors: Barazesh Mahdi , Mohammadi Shiva , Bahrami Yadollah , Mokarram Pooneh , Morowvat Mohammad Hossein , Saidijam Massoud , Karimipoor Morteza , Kavousipour Soudabeh , Vosoughi Amir Reza , Khanaki Korosh 
Published: December 2020

Background:Neurodegenerative diseases are often the consequence of alterations in structures and functions of the Central Nervous System (CNS) in patients. Despite obtaining massive genomic information concerning the molecular basis of these diseases and since the neurological disorders are multifactorial, causal connections between pathological pathways at the molecular level and CNS disorders development have remained obscure and need to be elucidated to a great extent.Objective:Animal models serve as accessible and valuable tools for understanding and discovering the roles of causative factors in the development of neurodegenerative disorders and finding appropriate treatments. Contrary to rodents and other small animals, large animals, especially non-human primates (NHPs), are remarkably similar to humans; hence, they establish suitable models for recapitulating the main human’s neuropathological manifestations that may not be seen in rodent models. In addition, they serve as useful models to discover effective therapeutic targets for neurodegenerative disorders due to their similarity to humans in terms of physiology, evolutionary distance, anatomy, and behavior.Methods:In this review, we recommend different strategies based on the CRISPR-Cas9 system for generating animal models of human neurodegenerative disorders and explaining in vivo CRISPR-Cas9 delivery procedures that are applied to disease models for therapeutic purposes.Results:With the emergence of CRISPR/Cas9 as a modern specific gene-editing technology in the field of genetic engineering, genetic modification procedures such as gene knock-in and knock-out have become increasingly easier compared to traditional gene targeting techniques. Unlike the old techniques, this versatile technology can efficiently generate transgenic large animal models without the need to complicate lab instruments. Hence, these animals can accurately replicate the signs of neurodegenerative disorders.Conclusion:Preclinical applications of CRISPR/Cas9 gene-editing technology supply a unique opportunity to establish animal models of neurodegenerative disorders with high accuracy and facilitate perspectives for breakthroughs in the research on the nervous system disease therapy and drug discovery. Furthermore, the useful outcomes of CRISPR applications in various clinical phases are hopeful for their translation to the clinic in a short time.
Natural Chemical Entities as Bioactive Moiety from Weaver Ant, Oecophylla smaragdina: An In Vitro and In-silico Study
Authors: Behera Suchismeeta , Dash Priyanka , Behera Amulyaratna , Behera Chinmaya Chidananda , Mohanty Prafulla Kumar 
Published: December 2020

Background:
Since time immemorial, the ethnic community of Mayrubhanj District,
Odisha, India has preferred Olecophylla smaragdina as traditional medicine for their multiple
ailments. Hence, the objective of this investigation is to scientifically examine the myth behind
ethno-zoological claims using chemometric analysis as well as in vitro and in silico study.

Materials and Methods:
The maceration method was used for the extraction of O. smaragdina using
hexane and methanol. In this study, various bioactive compounds of O. smaragdina were identified
through GC-MS analysis followed by an antimicrobial activity. The species were further studied for
their binding modes for in silico inhibition of a choice of bacterial proteins using Biovia Discovery
studio software.

Results:
Tetradecanoic acid, hexadecanoic acid, methyl ester, hexadecenoic acid, n-hexadecanoic
acid, 9-octadecenoic acid, methyl ester, oleic acid and 9-octadecenamide are some important bioactive
constituents identified through GCMS analysis. The hexane extract was found to have maximum
inhibitory activity against Staphyllococus aureus. The inhibitory activity of hexane and methanolic
extract against S. aureus at a concentration of 400 μg/mL was found to be 90% and 83%, respectively.
The high inhibitory capacity of the n-hexane extract was comparable to the standard drug
Gentamycin which further supported the high receptor binding affinity of the identified compound
Octadecanoic acid towards Tyrosol-t RNA synthetase of staphylococcus aureus (PDB ID: 1JIK).

Conclusion:
Interestingly, this is probably the first report that obtained bioactive molecules from
O. smaragdina showing the binding site identification to carry out molecular docking studies, and
better affinity to bind with suitable targeted moiety.
Benzimidazole as Ubiquitous Structural Fragment: An Update on Development of its Green Synthetic Approaches
Authors: Patel Ashish , Shah Drashti , Patel Naiya , Patel Khushbu , Soni Nidhi , Nagani Afzal , Parikh Vruti , Shah Hirak , Bambharoliya Tushar 
Published: December 2020

Abstract::
The benzimidazole and its derivatives are privileged heterocyclic motif and important building block for the
development of the biologically active compound. However, several research reports are produced in a short period of time
due to the rapid production of new drugs having a benzimidazole nucleus. In order to understand the current status of the
benzimidazole nucleus in medicinal chemistry science, it is therefore important to combine the latest knowledge with earlier
information. Hence, synthetic organic chemists concentrated on inventing an effective green methodology for
synthesizing benzimidazole derivatives. In addition to this, non-degradable chemical compounds cause the
ecosystem to become fragile, damage or irritation as contaminants and pose a danger to the environment.
However, conventional methods of synthesis need longer heating time, complicated and tedious apparatus set up which
result in high cost and pollution in contrast to greener methods which are inexpensive. In the present review, therefore, we
have attempted to shed light on various synthetic strategies leading to the synthesis of different benzimidazole derivatives
through the direct condensation reaction between o-phenylenediamine and aromatic aldehydes using green chemistry
approaches such as mechanochemistry, ultrasound irradiation, microwave irradiation, environmentally benign
solvents/catalysts, reactant immobilized on a solid support and blue light irradiation.
Impact of Metabolic Surgery on Type-2 Diabetes Remission
Authors: Baiocchi Cejana de Abrantes Figueiredo , Rocha de Sá Diana Aristótelis 
Published: December 2020

Abstract::Diabetes Mellitus is characterized by numerous metabolic disorders, which have in common the serum elevation of glucose, caused for a pancreatic malfunction in insulin secretion and / or its action. It is a non-communicable disease, considered major public health problems and generalized growth worldwide, being a chronic disease, which can generate a high treatment cost. Metabolic surgery is a safe treatment, regulated by the Federal Council of Medicine and useful in treating people with BMI over 30 years of age, who are unable to control pathologies associated with obesity, primarily type 2 diabetes. The general objective of this study is to understand through a literature review the main impacts of metabolic surgery about the remission of DM 2. This present study it is an exploratory and descriptive study carried out through a literature review. Data were collected through research in virtual health databases, at the Virtual Health Library - VHL, Latin American and Caribbean Health Sciences Information System, LILACS, National Library of Medicine - MEDLINE, Scielo, USP database, PUBMED theses and books. Metabolic surgery proof be a good and effective treatment for having and maintaining good weight loss, as well as a significant clinical and metabolic improvement that extends beyond weight loss. Metabolic surgery is a satisfactory way of achieving long-term weight reduction in obese individuals, increasing survival for these patients. Obese patients with DM2 have a long-term remission of DM2 after bariatric / metabolic surgery. Therefore, it concludes that such procedure is effective in the treatment of the disease and other diseases associated with obesity.
Neuroendocrine Response to Psychosocial Stressors, Inflammation Mediators and Brain-periphery Pathways of Adaptation
Authors: Palego Lionella , Giannaccini Gino , Betti Laura 
Published: December 2020

Abstract::
Threats, challenging events, adverse experiences, predictable or unpredictable, namely
stressors, characterize life, being unavoidable for humans. The hypothalamus-pituitary-adrenal
axis (HPA) and the sympathetic nervous system (SNS) are well-known to underlie adaptation to
psychosocial stress in the context of other interacting systems, signals and mediators. However,
much more effort is necessary to elucidate these modulatory cues for a better understanding of
how and why the "brain-body axis" acts for resilience or, on the contrary, cannot cope with stress
from a biochemical and biological point of view. Indeed, failure to adapt increases the risk of developing
and/or relapsing mental illnesses such as burnout, post-traumatic stress disorder
(PTSD), and at least some types of depression, even favoring/worsening neurodegenerative and
somatic comorbidities, especially in the elderly.
We will review here the current knowledge on this area, focusing on works presenting the main
brain centers responsible for stressor interpretation and processing, together with those underscoring
the physiology/biochemistry of endogenous stress responses. Autonomic and HPA patterns,
inflammatory cascades and energy/redox metabolic arrays will be presented as allostasis
promoters, leading towards adaptation to psychosocial stress and homeostasis, but also as possible
vulnerability factors for allostatic overload and non-adaptive reactions. Besides, the existence
of allostasis buffering systems will be treated. Finally, we will suggest promising lines of future
research, particularly the use of animal and cell culture models together with human studies by
means of high-throughput multi-omics technologies, which could entangle the biochemical signature
of resilience or stress-related illness, a considerably helpful facet for improving patients’
treatment and monitoring.
Composite Membrane and Evaluation on Separation Oil/Water
Authors: de Oliveira Luana Araújo , Rodrigues Meiry Gláucia Freire , dos Santos Barbosa Antonielly , Cunha Rochélia Silva Souza , Mota Joseane Damasceno 
Published: December 2020

Background:
The generation of wastewater contaminated with organic compounds, release or spill into these
water bodies can lead to serious environmental problems. The removal of chemical pollutants in water presents itself as
one of the central issues regarding the issue of environmental remediation. In this sense, membranes, haves gained
increasing importance in the environmental area.

Objective:
This present study aims to develop a composite membrane
using UHMWPE/LDPE/CTAC-HGC to be used for oil/water separation of wastewater effluents.

Methods:
The
polymeric membrane and composite membrane were prepared by uniaxial dry compaction and sintering. Both hard green
clay (HGC) and hard green clay organophilized with cetyl trimethyl ammonium chloride (CTAC-HGC) were
characterized by X-ray Diffraction (XRD), infrared spectroscopy (IR) and scanning electron microscopy (SEM).
UHMWPE, polymeric membrane and composite membrane were characterized by XRD and SEM.

Result:
The water flux
through the composite membrane was evaluated using pure water as a permeate. The potential of the composite membrane
to separate oil-water emulsions was tested.

Conclusions:
The composite membrane showed excellent removal of the oil,
exhibiting removal of more than 99.60 %, evidencing the process of composite membrane separation as an alternative
technology for the treatment of oil.
Wonderen in de Bijbel
Authors: van de Beek A. 
Published: December 2020

Miracles in the Bible are not unnatural. Rather, they are singular events or stories about singular events which make people wonder or evoke reactions. Some of these events are historical such as the exodus of Israel from Egypt. Others, such as Gods descent on Mount Sinai remain beyond normal history, or they relate a divine act which initiates history, or put it into a new perspective, such as the narrative about creation and the birth and resurrection of Jesus. These do not represent normal historical discourse. Still others, the parables and Jonah, correct human thoughts and attitudes. When reflecting on miracles in the Bible, therefore, it is important to take into account the literary genre and the character of events which are told. It is not sufficient or often not even possible to answer the question: ‘Did it really happen or not?’ The biblical miracle stories tell us about God and Jesus in whom He manifested himself, both of which are beyond human comprehension and rationality, as is the Resurrection.
Wonderen als tekenen van heiligheid
Authors: Lindeijer S.J. M. 
Published: December 2020

Miracles, like the saints, are one of the most wondrous parts of the life of the Church since the earliest times. As ‘the finger of God’ pointing to sanctity (pope Francis), they play a particular role in canonization. The procedures to ascertain miracles, 95% of them healings, have been refined over the past four centuries, particularly in the 20th century, which also saw fundamental developments in the theology of miracles. Since 1983 fewer miracles have been required for a beatification or canonization. Some candidates for sainthood have been raised to the altar on the basis of a single miracle, based on the common intercession of the saints.
Focus. Een blijvend lastig thema: geweld
Authors: Peels H.G.L. 
Published: December 2020

N.a.v. Jacques van Ruiten and Koert van Bekkum (red.), Violence in the Hebrew Bible between Text and Reception [Oudtestamentische Studiën 79] (Leiden/Boston: Brill, 2020), x + 438 p., € 138,00 (ISBN 9789004434677).
Магнитные свойства композита частиц DyMn-=SUB=-2-=/SUB=-O-=SUB=-5-=/SUB=--Mn-=SUB=-3-=/SUB=-O-=SUB=-4-=/SUB=-
Authors: Патрин Г.С. , Матаев М.М. , Абдраймова М.Р. , Турсинова Ж.И. , Кездикбаева А.Т. , Шиян Я.Г. , Плеханов В.Г. 
Published: December 2020

The paper presents the results of the experimental studies of magnetic and resonance properties of the DyMn2O5 – Mn3O4 particles composite. There are two magnetic transitions at temperatures T1  65 K and T2  230 K. T1 differs from the transition temperatures for the initial materials, and this fact is associated with the interparticle interaction. T2 corresponds to the impurity phase DyMnO3 (1 at.%). Three peaks of microwave absorption are observed in the magnetic resonance spectrum, which is explained in the framework of the model of a two-phase system in magnetic relation. One resonance is attributed to Mn3O4 and the other two peaks refer to the ensemble of strongly anisotropic DyMn2O5 particles with a random distribution of anisotropy axes.

Patrin Gennady Semionovich1,3
Mataev Mukhametkali Musagalievich2
Abdraimova Moldir Rashidovna2
Tursinova Zhanar Iliyasovna2
Kezdikbaeva Asel Taupykovna4
Shiyan Yaroslav Germanovich1,3
Plekhanov Vasil Granitovich1

1 Siberian Federal University, Svobodny pr. 79, Krasnoyarsk, 660041, Russia
2	Kazakh State Women’s Teacher Training University, Aiteke bi, 99, Almaty, 050000, Kazakhstan
3	L.V. Kirensky Institute of Physics, Federal Research Center KSC, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, 660036 Russia
4	E.A. Buketov Karaganda State University, st. University 28, City of Karaganda, 100028, Kazakhstan
Heart Rate Measurements in Patients with Obstructive Sleep Apnea and Atrial Fibrillation: Prospective Pilot Study Assessing Apple Watch’s Agreement With Telemetry Data
Authors: Huynh Pauline , Shan Rongzi , Osuji Ngozi , Ding Jie , Isakadze Nino , Marvel Francoise A , Sharma Garima , Martin Seth S 
Published: December 2020

Background
Patients with obstructive sleep apnea (OSA) are at a higher risk for atrial fibrillation (AF). Consumer wearable heart rate (HR) sensors may be a means for passive HR monitoring in patients with AF.

Objective
The aim of this study was to assess the Apple Watch’s agreement with telemetry in measuring HR in patients with OSA in AF.

Methods
Patients with OSA in AF were prospectively recruited prior to cardioversion/ablation procedures. HR was sampled every 10 seconds for 60 seconds using telemetry and an Apple Watch concomitantly. Agreement of Apple Watch with telemetry, which is the current gold-standard device for measuring HR, was assessed using mixed effects limits agreement and Lin’s concordance correlation coefficient.

Results
A total of 20 patients (mean 66 [SD 6.5] years, 85% [n=17] male) participated in this study, yielding 134 HR observations per device. Modified Bland–Altman plot revealed that the variability of the paired difference of the Apple Watch compared with telemetry increased as the magnitude of HR measurements increased. The Apple Watch produced regression-based 95% limits of agreement of 27.8 – 0.3 × average HR – 15.0 to 27.8 – 0.3 × average HR + 15.0 beats per minute (bpm) with a mean bias of 27.8 – 0.33 × average HR bpm. Lin’s concordance correlation coefficient was 0.88 (95% CI 0.85-0.91), suggesting acceptable agreement between the Apple Watch and telemetry.

Conclusions
In patients with OSA in AF, the Apple Watch provided acceptable agreement with HR measurements by telemetry. Further studies with larger sample populations and wider range of HR are needed to confirm these findings.