bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individualised stepwise adaptive treatment for 3–6-year-old preschool children impaired by attention-deficit/hyperactivity disorder (ESCApreschool): study protocol of an adaptive intervention study including two randomised controlled trials within the consortium ESCAlife
Authors: Becker Katja , Banaschewski Tobias , Brandeis Daniel , Dose Christina , Hautmann Christopher , Holtmann Martin , Jans Thomas , Jendreizik Lea , Jenkner Carolin , John Katja , Ketter Johanna , Millenet Sabina , Pauli-Pott Ursula , Renner Tobias , Romanos Marcel , Treier Anne-Katrin , von Wirth Elena , Wermter Anne-Kathrin , Döpfner Manfred 
Published: January 2020

Abstract
Background
Attention-deficit/hyperactivity disorder (ADHD) is a psychosocially impairing and cost-intensive mental disorder, with first symptoms occurring in early childhood. It can usually be diagnosed reliably at preschool age. Early detection of children with ADHD symptoms and an early, age-appropriate treatment are needed in order to reduce symptoms, prevent secondary problems and enable a better school start. Despite existing ADHD treatment research and guideline recommendations for the treatment of ADHD in preschool children, there is still a need to optimise individualised treatment strategies in order to improve outcomes. Therefore, the ESCApreschool study (Evidence-Based, Stepped Care of ADHD in Preschool Children aged 3 years and 0 months to 6 years and 11 months of age (3;0 to 6;11 years) addresses the treatment of 3–6-year-old preschool children with elevated ADHD symptoms within a large multicentre trial. The study aims to investigate the efficacy of an individualised stepwise-intensifying treatment programme.

Methods
The target sample size of ESCApreschool is 200 children (boys and girls) aged 3;0 to 6;11 years with an ADHD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) or a diagnosis of oppositional defiant disorder (ODD) plus additional substantial ADHD symptoms. The first step of the adaptive, stepped care design used in ESCApreschool consists of a telephone-assisted self-help (TASH) intervention for parents. Participants are randomised to either the TASH group or a waiting control group. The treatment in step 2 depends on the outcome of step 1: TASH responders without significant residual ADHD/ODD symptoms receive booster sessions of TASH. Partial or non-responders of step 1 are randomised again to either parent management and preschool teacher training or treatment as usual.

Discussion
The ESCApreschool trial aims to improve knowledge about individualised treatment strategies for preschool children with ADHD following an adaptive stepped care approach, and to provide a scientific basis for individualised medicine for preschool children with ADHD in routine clinical care.

Trial registration
The trial was registered at the German Clinical Trials Register (DRKS) as a Current Controlled Trial under DRKS00008971 on 1 October 2015. This manuscript is based on protocol version 3 (14 October 2016).
The efficacy and safety of electro-acupuncture for alleviating chemotherapy-induced peripheral neuropathy in patients with coloreactal cancer: study protocol for a single-blinded, randomized sham-controlled trial
Authors: Chan Kaiyin , Lui Louisa , Yu Kaling , Lau Kwongwai , Lai Manchi , Lau Waiwai , Ng Bacon , Zhong Linda L. D. , Bian Zhao-Xiang 
Published: January 2020

Abstract
Background
Colorectal cancer is the most common cancer in Hong Kong. Oxaliplatin-based chemotherapy is a major first-line conventional therapy for advanced and metastatic colorectal cancer. However, oxaliplatin causes chemotherapy-induced peripheral neuropathy (CIPN). Acupuncture has long been used to alleviate limb numbness in Chinese medicine. This study aims to examine the efficacy and safety of acupuncture for alleviating CIPN in patients with colorectal cancer in Hong Kong.

Methods/design
This is a single-blinded, randomized, sham-controlled efficacy trial. Eighty-four eligible patients, who are Hong Kong Chinese, aged ≥ 18 years, diagnosed with colorectal cancer and undergoing oxaliplatin-based chemotherapy, will be randomized in a ratio of 1:1 to the electro-acupuncture group or the sham-controlled group. During a 12-week treatment period, patients in the electro-acupuncture group will undergo electro-acupuncture once a week from the first cycle of chemotherapy, while patients in the control group will receive sham acupuncture, and the patients in both groups will be followed up for 12 weeks. The primary outcome measure is the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOC-Ntx) questionnaire. The secondary outcome measures include numerical rating scale (NRS) for numbness/pain, vibration and light touch sense test, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) and Constitution of Chinese Medicine Questionnaire (CCMQ).

Discussion
The study will compare electro-acupuncture with sham acupuncture to explore the feasibility for electro-acupuncture in improving symptoms caused by chemotherapy-induced peripheral neuropathy.

Trial registration
Clinicaltrials.gov, NCT03582423. Registered on 11 July 2018.
Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans
Authors: Stutzman Alexis V. , Liang April S. , Beilinson Vera , Ikegami Kohta 
Published: January 2020

AbstractBackgroundChromatin organization is central to precise control of gene expression. In various eukaryotic species, domains of pervasivecis-chromatin interactions demarcate functional domains of the genomes. In nematodeCaenorhabditis elegans, however, pervasive chromatin contact domains are limited to the dosage-compensated sex chromosome, leaving the principle ofC. eleganschromatin organization unclear. Transcription factor III C (TFIIIC) is a basal transcription factor complex for RNA polymerase III, and is implicated in chromatin organization. TFIIIC binding without RNA polymerase III co-occupancy, referred to as extra-TFIIIC binding, has been implicated in insulating active and inactive chromatin domains in yeasts, flies, and mammalian cells. Whether extra-TFIIIC sites are present and contribute to chromatin organization inC. elegansremains unknown.ResultsWe identified 504 TFIIIC-bound sites absent of RNA polymerase III and TATA-binding protein co-occupancy characteristic of extra-TFIIIC sites inC. elegansembryos. Extra-TFIIIC sites constituted half of all identified TFIIIC binding sites in the genome. Extra-TFIIIC sites formed dense clusters incis.The clusters of extra-TFIIIC sites were highly over-represented within the distal arm domains of the autosomes that presented a high level of heterochromatin-associated histone H3K9 trimethylation (H3K9me3). Furthermore, extra-TFIIIC clusters were embedded in the lamina-associated domains. Despite the heterochromatin environment of extra-TFIIIC sites, the individual clusters of extra-TFIIIC sites were devoid of and resided near the individual H3K9me3-marked regions.ConclusionClusters of extra-TFIIIC sites were pervasive in the arm domains ofC. elegansautosomes, near the outer boundaries of H3K9me3-marked regions. Given the reported activity of extra-TFIIIC sites in heterochromatin insulation in yeasts, our observation raised the possibility that TFIIIC may also demarcate heterochromatin inC. elegans.
The Landscape Montage Technique for diagnosing frontotemporal dementia starting as primary progressive aphasia: a case report
Authors: Takaya Masahiko , Ishii Kazunari , Kubota Isao , Shirakawa Osamu 
Published: January 2020

Abstract
Background
The Landscape Montage Technique was originally developed by Hisao Nakai, a Japanese psychiatrist, to pursue the possibility and application of a psychotherapeutic approach using drawing for patients with schizophrenia. Drawing was initially adopted to evaluate patients with an impaired ability for verbal expression, particularly for the diagnosis and treatment of patients with schizophrenia. Since its development, the Landscape Montage Technique has been utilized in various clinical settings throughout Japan. This study aimed to evaluate the psychiatric conditions of a patient diagnosed as having primary progressive aphasia using the Landscape Montage Technique at a 3-year follow-up.

Case presentation
We present the case of a 64-year-old, right-handed Japanese woman initially diagnosed as having logopenic variant primary progressive aphasia or logopenic aphasia. At a 3-year follow-up, logopenic aphasia progressed to behavioral variant frontotemporal dementia or frontotemporal dementia. According to her husband, she began to have speech difficulties approximately 5 years before her first visit. The results of neurocognitive tests suggested mild cognitive impairment or early stages of dementia. Her clinical dementia rating score was 0.5, suggesting a diagnosis of mild cognitive impairment. She had a Raven’s Colored Progressive Matrices score of 31 out of 36, which indicated a nonverbal cognitive ability that was greater than the 90th percentile for her age. The Japanese Standard Language Test of Aphasia, which was performed at two points during the follow-up, indicated the possibility for a diagnosis of primary progressive aphasia given the progression of her aphasia. Based on her clinical symptoms and Japanese Standard Language Test of Aphasia results, a diagnosis of logopenic variant primary progressive aphasia was established. Magnetic resonance imaging revealed severe predominant left frontal and anterior temporal atrophy, as well as bilateral parietal atrophy. Amyloid beta deposition was negative. At the 3-year follow-up, logopenic variant primary progressive aphasia had progressed to behavioral variant frontotemporal dementia. However, the Landscape Montage Technique allowed for the diagnosis of behavioral variant frontotemporal dementia only 2 years after baseline.

Conclusions
The present study showed that the Landscape Montage Technique can be useful for diagnosing behavioral variant frontotemporal dementia that starts as logopenic variant primary progressive aphasia at earlier stages.
Factors influencing livestock export in Somaliland’s terminal markets
Authors: Musa Ahmed M. , Wasonga Oliver Vivian , Mtimet Nadhem 
Published: January 2020

AbstractLivestock export from Somaliland to the Arabian Peninsula countries is an important economic activity and the main source of Somaliland’s foreign exchange earnings. We have employed multiple regression time series analysis of secondary data to understand factors that influence the monthly volumes of small ruminants (sheep and goats) and cattle traded for export in three terminal markets in Somaliland. Results show that the Hajj season, number of livestock exporters active in the markets, market location and livestock ban imposed by the import countries are the main factors that influence the monthly volume of livestock transacted for export. Further, the results indicate that though drought does not influence the volume of small ruminants, it has an influence on the volume of cattle, while the implementation of quarantine stations has a significant influence on the volumes of livestock exports. Finally, border restrictions imposed by Ethiopia do not influence the volume of livestock transacted for export in the study markets. Most of the factors analysed to have influence on monthly volume livestock transacted for export are institutional and policy-related hence can be corrected though requisite regulatory, institutional and policy reforms in consultations with stakeholders.
A novel de novo partial xq duplication in a girl with short stature, nonverbal learning disability and diminished ovarian reserve - effect of growth hormone treatment and fertility preservation strategies: a case report and up-to-date review
Authors: Parissone Francesca , Pucci Mairi , Meneghelli Emanuela , Zuffardi Orsetta , Di Paola Rossana , Zaffagnini Stefano , Franchi Massimo , Santangelo Elisabetta , Cantalupo Gaetano , Cavarzere Paolo , Antoniazzi Franco , Piacentini Giorgio , Gaudino Rossella 
Published: January 2020

Abstract
Background
Xq duplication is a rare condition with a very variable phenotype, which could mimic other genetic syndromes involving the long arm of chromosome X. Sometimes short stature and diminished ovarian reserve (DOR) may be present. Treatments with rGH (Recombinant growth Hormon) or with fertility preservation strategies have not been previously described.

Case presentation
We present the case of a female with a novel de novo Xq partial duplication (karyotype: 46,Xder(X)(qter→q21.31::pter→qter) confirmed by array-CGH analysis. She presented with short stature, Nonverbal Learning Disability, developmental delay during childhood, severe scoliosis, spontaneous onset of menarche and irregular menstrual cycles. AMH (Anti-Müllerian Hormone) allowed detection of a preserved but severely diminished ovarian reserve with a POI (Premature Ovarian insufficiency) onset risk. She was effectively subjected to fertility preservation strategies and rGH therapy. We also reviewed other published cases with Xq duplication, reporting the main clinics characteristics and any adopted treatment.

Conclusions
rGH treatment and cryopreservation in a multidisciplinary approach are good therapeutic strategies for Xq duplication syndrome with short stature and premature ovarian failure.
On secure system performance over SISO, MISO and MIMO-NOMA wireless networks equipped a multiple antenna based on TAS protocol
Authors: Tran Thanh-Nam , Voznak Miroslav 
Published: January 2020

AbstractThis study examined how to improve system performance by equipping multiple antennae at a base station (BS) and all terminal users/mobile devices instead of a single antenna as in previous studies. Experimental investigations based on three NOMA down-link models involved (1) a single-input-single-output (SISO) scenario in which a single antenna was equipped at a BS and for all users, (2) a multi-input-single-output (MISO) scenario in which multiple transmitter antennae were equipped at a BS and a single receiver antenna for all users and (3) a multi-input-multi-output (MIMO) scenario in which multiple transmitter antennae were equipped at a BS and multiple receiver antenna for all users. This study investigated and compared the outage probability (OP) and system throughput assuming all users were over Rayleigh fading channels. The individual scenarios also each had an eavesdropper. Secure system performance of the individual scenarios was therefore also investigated. In order to detect data from superimposed signals, successive interference cancellation (SIC) was deployed for users, taking into account perfect, imperfect and fully imperfect SICs. The results of analysis of users in these three scenarios were obtained in an approximate closed form by using the Gaussian-Chebyshev quadrature method. However, the clearly and accurately presented results obtained using Monte Carlo simulations prove and verify that the MIMO-NOMA scenario equipped with multiple antennae significantly improved system performance.
Bit error rate performance analysis of AC-MAP in multiple input single output wireless relay network
Authors: Khalaf Taha A. , Mohammed Hazem 
Published: January 2020

AbstractIn this paper, we propose a joint decoding scheme called AC-MAP decoder for multiple input single output (MISO) wireless cooperative communication network that consists of single source, single relay, and single destination. The proposed scheme is based on both Alamouti combining (AC) scheme and maximum a posteriori (MAP) decoder and is used to estimate the data at the destination. The AC-MAP decoder is optimal in the sense that it minimizes the end-to-end bit error rate (BER). In order to analyze performance of the proposed decoder, we derive a closed form expression for the upper bound (UB) on the end-to-end error probability. Distances between system nodes, transmit energy, and channel noise and fading effects are considered in the derivation of the UB. Numerical results show that the closed form UB is very tight and it almost coincides with the exact BER results obtained from simulations. Therefore, we use the derived UB expression to study the effects of the relay position on the BER performance and to find the optimal location of the relay node.
A systematic review protocol examining workplace interventions that aim to improve employee health and wellbeing in male-dominated industries
Authors: Hulls Paige M. , Richmond Rebecca C. , Martin Richard M. , de Vocht Frank 
Published: January 2020

Abstract
Background
The workplace environment potentially provides access to a large population who are employed, and it is an employer's responsibility to provide appropriate conditions for its employees. Whilst the aetiology of cardiovascular disease is multifactorial, it is generally acknowledged that working conditions, gender and age are involved in its development. Male-dominated industries (comprising > 70% male workers, e.g., agriculture, construction, manufacturing, mining, transport and technology) have a higher prevalence of health risk behaviours than other population subgroups. Working in a gender-dominated industry can impact an employee's health and wellbeing, particularly for the opposite sex. This systematic review examines workplace interventions that address the health and wellbeing of employees in male-dominated industries.

Methods
We will include randomised controlled trials and studies with non-randomised intervention groups. The interventions must aim to improve employee physical and/or mental health and wellbeing implemented in the workplace in male-dominated industries. There will be no limits on date. The following electronic databases will be searched for published studies: Web of Science, Embed, MedLine, PsycInfo and the Cochrane Database. The search strategy will include free-text terms and MeSH vocabulary, including ‘male-dominated industries’, ‘workplace interventions’, ‘occupational stress’, ‘mental health’, ‘cardiovascular disease’, ‘blood pressure’, ‘body mass index’ and ‘exercise’. Two authors will independently select, review and extract data from studies that meet the inclusion criteria. The Cochrane's Risk of Bias tool will be used to assess risk of bias. We will perform structured summaries of the included studies and, if possible, conduct meta-analyses or construct an Albatross plot.

Discussion
There are an increasing number of interventions designed to improve employee health and wellbeing in the workplace, but no prior review that systematically evaluates their effectiveness. A systematic review is required to prioritise the future implementation of those interventions found to be most effective.

Systematic review registration
PROSPERO CRD42019161283
On HT-convexity and Hadamard-type inequalities
Authors: Bai Shu-Ping , Wang Shu-Hong , Qi Feng 
Published: January 2020

AbstractIn the paper, the authors define a new notion of “HT-convex function”, present some Hadamard-type inequalities for the new class of HT-convex functions and for the product of any two HT-convex functions, and derive some inequalities for the arithmetic mean and thep-logarithmic mean. These results generalize corresponding ones for HA-convex functions and MT-convex functions.
Technical and clinical evaluation of a closed loop TIVA system with SEDLineTM spectral density monitoring: Multicentric prospective cohort study
Authors: Castellanos Peñaranda Claudia , Casas Arroyave Fabián D. , Gómez Francisco J. , Pinzón Corredor Paola A. , Fernández Juan M. , Velez Botero Marcela , Bohórquez Bedoya Juan D. , Marulanda Toro Carlos 
Published: January 2020

Abstract
Introduction
Closed loop total intravenous anesthesia is a technique in which the patient’s hemodynamic and anesthetic depth variables are monitored, and based on this information, a computer controls the infusion rate of drugs to keep them within pre-established clinical parameters.

Objective
To describe the technical and clinical performance of a closed loop system for total intravenous anesthesia with propofol and remifentanil, using the SEDLineTM monitor

Design
Multicentric prospective cohort study

Setting
Surgery room

Patients
ASA I-II undergoing elective surgery

Measurements
The authors designed a closed loop system that implements a control algorithm based on anesthetic depth monitoring and the Patient State Index (PSITM) of the SEDLine monitor for propofol, and on hemodynamic variables for remifentanil. The measurement of clinical performance was made based on the percentage of PSITM maintenance time in the range 20–50. Precision analysis was evaluated by measuring median performance error (MDPE) can be defined as the median difference between actual and desired values, which refers to the degree of precision in which the controller is able to maintain the control variable within the objective set by the anesthesiologist; it represents the direction (over-prediction or under-prediction) of performance error (PE) rather than size of errors, which is represented by MDAPE, median absolute percentage error, Wobble index, which is used for measuring the intrasubject variability in performance error.

Results
Data were obtained from 93 patients in three healthcare centers. The percentage of PSITM maintenance time in the 20–50 range was 92% (80.7–97.0). MDPE was 10.7 (− 11.0–18.0), MDAPE 21.0 (14.2–26.8) and wobble 10.7 (7.0–16.9). No adverse surgical or anesthetic events were found.

Conclusions
The closed loop total intravenous anesthesia system with SEDLine developed by the authors was used without major complication and appear to be feasible its use in clinical performance.
Risk factors for quinolone-resistant Escherichia coli infection: a systematic review and meta-analysis
Authors: Zhu Dong-Mei , Li Qiu-Hong , Shen Yan , Zhang Qin 
Published: January 2020

Abstract
Background
Antimicrobial resistance to quinolone is rising worldwide, especially in Escherichia coli causing various infections. Although many studies have been conducted to identify the risk factors for quinolone-resistant Escherichia coli (QREC) infection, the results are inconsistent and have not been systematically reported. The aim of the present study is to conduct a systematic review and meta-analysis to evaluate the potential risk factors for QREC infection.

Methods
A systematic search was performed to collect published data in the EMBASE, PubMed, and the Cochrane Library up to April 2019. Risk factors were analyzed using the pooled odds ratio (ORs) with 95% confidence interval (CIs).

Results
Twenty-seven trials involving 67,019 participants were included in the present study. The following risk factors associated with QREC infection were identified: (1) male (OR = 1.41), (2) hepatic cirrhosis (OR = 2.05), (3) diabetes mellitus (OR = 1.62), (4) cardiovascular disease (OR = 1.76), (5) neurogenic bladder (OR = 8.66), (6) renal dysfunction (OR = 2.47), (7) transplantation (OR = 2.37), (8) urinary tract infection (OR = 2.79) and urinary tract abnormality (OR = 1.85), (9) dementia (OR = 5.83), (10) heart failure (OR = 5.63), (11) neurologic disease (OR = 2.80), (12) immunosuppressive drugs (OR = 2.02), (13) urinary catheter (OR = 4.39), (14) nursing home resident (OR = 4.63), (15) prior surgery (OR = 2.54), (16) quinolones (OR = 7.67), (17) other antibiotics (OR = 2.74), (18) hospitalization (OR = 2.06) and (19) nosocomial infection acquisition (OR = 2.35).

Conclusions
QREC infection was associated with nineteen risk factors including prior quinolones use, hospitalization, and several comorbidities. Reducing exposure to these risk factors and modification of antibiotic use are important to prevent quinolone resistance.