bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model Pembelajaran Bahasa Arab Multiliterasi Berbasis Kearifan Lokal Dan Moderasi Islam di Perguruan Tinggi Negeri
Authors: Hadiyanto Andy , Samitri Cendra , Maria Ulfah Siti 
Published: January 2020

Penelitian ini bertujuan untuk mengembangkan suatu pembelajaran bahasa Arab multiliterasi berbasis kearifan lokal di Perguran Tinggi Umum yang valid, efektif, efisien, dan praktis sehingga dapat dijadikan alternatif model pembelajaran lain yang diterapkan oleh dosen bahasa Arab. Penelitian ini menggunakan pendekatan kualitatif dengan pola “the dominantless dominant design” dan desain penelitian research and development (R & D). Penelitian dilakukan melalui dua tahapan: (1) Studi Pendahuluan (Exploration study), dan (2) Pengembangan model (Action Research. Pengumpulan data dengan wawancara, observasi, dokumentasi, angket (test), dan FGD. Hasil penelitian menunjukkan: 1) pembelajaran bahasa Arab masih terlalu bersifat behavioristik dan sekadar menghasilkan keterampilan berbahasa mekanistik, 2) Pembelajaran bahasa Arab multiliterasi harus memungkinkan mahasiswa agar dapat melakukan proses intensifikasi dan ekstensifikasi kemampuannya dalam berkomunikasi menggunakan bahasa Arab sehingga mengembangkan kemampuan dan keterampilan komunikasi menggunakan bahasa Arab secara mandiri dengan menggunakan multisumber dan media, 3) pembelajaran bahasa Arab multiliterasi yang mendudukan mahasiswa dalam konteks kehidupan riilnya harus diiringi dengan pemahaman dan keinsafan tentang pentingnya integrasi kearifan lokal Indonesia dalam proses pembelajaran, 4) Komponen dan sintaks model pembelajaran bahasa Arab multiliterasi berbasis kearifan lokal mengacu pada temuan empiris dan teoretik, yakni tujuan, metode, materi, serta evaluasi pembelajaran.
DUROPHAGOUS FISH PREDATION TRACES VERSUS TUMBLING-INDUCED SHELL DAMAGE—A PALEOBIOLOGICAL PERSPECTIVE
Authors: SALAMON MARIUSZ A. , BRACHANIEC TOMASZ , GORZELAK PRZEMYSŁAW 
Published: January 2020

ABSTRACTDurophagous (shell-crushing) fish predation is considered to have been a major force of evolutionary change in the history of marine communities. However, because fish predators are very rarely preserved in the act of predation, fossil evidence of such interactions is commonly indirect. For instance, it has been argued that shell fragments with sharp margins constitute a good proxy for durophagy. However, drawing a distinction between predation- and abiotic-induced shell damage can be challenging. Notably, experimental data on shell fragmentation by marine durophagous fishes are almost lacking. In this study, we explore whether shell breakage caused by durophagous marine fishes versus physical factors can be distinguished. Aquarium experiments involving commercially available predatory fishes (Diodon) and thin-shelled invertebrate preys (gastropods Nassarius and brachiopods Frenulina) show that the predation by some fish produces shell fragments displaying extremely low roundness and varying degree of sphericity. Importantly, these fragments typically display sharp and jagged margins, and reveal distortion of individual crystal fibers. Tumbling experiments showed that the disintegration of brachiopod shells proceeds much more rapidly than that of gastropods, which may suggest that abiotic-induced fragmentation of brachiopods may be eventually confused with predation. However, the tumbling-induced fragmentation and damage in both groups are typically characterized by the presence of spherical or discoidal and rounded shell fragments displaying smooth edges (without any microstructural distortion), and numerous abrasive scratches and wear scars on the surface. These data underscore that the shell fragments produced by a durophagous fish, if not subsequently abraded by physical factors, can be recognized in the fossil record.
Analyzing the interactions of circRNAs, miRNAs, and mRNAs to predict ceRNA networks in human acute type A aortic dissection
Authors: huang maoxun , piao hulin , wang yong , wang weitie , li bo , zhu zhicheng , xu rihao , li dan , wang tiance , liu kexiang 
Published: January 2020

Abstract
The authors have withdrawn this preprint from Research Square.
Distribution of hepatitis B virus genotypes in general population of Myanmar via Nation wide study
Authors: Kyaw Yi Yi , Lwin Aye Aye , Aye Khin Saw , Thu Hlaing Myat , Htun Moh Moh , Soe Hnin Ohmar , Aye Kay Thi , Thant Kyaw Zin , Hwang Hyeon Jeong , Cheong JaeHun 
Published: January 2020

Abstract
Background Hepatitis B virus (HBV) infection is a severe health concern worldwide. HBV is a DNA virus with a rapid rate of mutation. Based on the heterogeneity of the HBV nucleotide sequence, the HBV strains are divided into ten genotypes, A to J, with a characteristic geographical distribution. Identifying and tracking the changes of HBV genotypes is important in epidemiological and transmission studies, predicting the risk for the development of severe liver disease and response to antiviral treatment. The present study was conducted to detect HBV genotypes and sub-genotypes in general population of different states and regions in Myanmar. Methods A total of 5,547 general adult population who residing at seven states, seven regions and Nay Pyi Taw Union Territory were screened for Hepatitis B Surface antigen (HBsAg) by Immunochromatgraphic test (ICT) in 2015. Of 353 HBsAg positive samples, HBV DNA were detected by using polymerase chain reactions (PCR) targeting the DNA sequences encoding the Pre-S region. A total of 153 PCR positive samples were preceded for genotyping by partial genome sequencing of both directions. The resulting sequences were then edited, aligned and compared with reference sequences using National Centre for Biotechnology Information (NCBI) web based genotyping tool. Results Three HBV genotypes; HBV/ C, HBV/ D and HBV/ B were detected in Myanmar, in which genotype HBV/ C (66.7%) was the most prevalent genotype followed by HBV/ D (32%) and HBV/ B (1.3%) respectively. Sub-genotyping revealed a total of 7 sub-genotypes within genotypes B, C and D: two (B4 and B5) in HBV/ B, three (C1, C5 and C7) in HBV/C and two (D3 and D6) in HBV/ D. Conclusion Genotype HBV/C, sub-genotype C1 was the most predominant genotype distributed in all states and regions of Myanmar. This study was first report on Nation- wide distribution of HBV genotype and sub-genotypes in Myanmar and the findings will be a huge support for hepatitis disease surveillance programme which is the one of the National Priority Diseases in Myanmar.
Plasma HER2ECD a promising test for patient prognosis and prediction of response in HER2 positive breast cancer: Results of a randomized study - SAKK 22/99
Authors: Eppenberger-Castori Serenella , Klingbiel Dirk , Ruhstaller Thomas , Dietrich Daniel , Rufle Daniel Alexander , Rothgiesser Karin , Pagani Olivia , Thürlimann Beat 
Published: January 2020

Abstract
Background
The HER2 extracellular domain shed in blood (HER2 ECD ) is reported to rise and fall in parallel with HER2+ breast cancer behavior. In this study, we evaluated the clinical relevance of plasma HER2 ECD values in patients with metastatic breast cancer treated in the SAKK22/99 trial comparing trastuzumab monotherapy followed by trastuzumab-chemotherapy combination at progression versus upfront combination therapy.
Methods
Quantitative assessment of plasma HER2 ECD was performed in 133 patients at baseline; after 2-24 hours; at 3 weeks; at first response evaluation (8-9 weeks); and at tumor progression. Associations with tumor characteristics, disease course and trial treatment were evaluated.
Results
Baseline HER2 ECD levels were stable within 24 hours after the first trastuzumab injection. These plasma values correlated positively with the HER2 gene ratio (r s =0.39, P <0.001) and HER2 protein expression levels (r s =0.36, P <0.001) but not with ER/PR status of the primary tumor. HER2 ECD baseline levels were positively associated with the presence of visceral disease ( P =0.05) and poor patients’ outcome (Cox-regression: P =0.009). Patients with high baseline levels ( > 35ng/ml) had the worst overall survival ( P =0.03) if treated with upfront combination therapy. Conversely, patients with low HER2 ECD baseline values (<15ng/ml) had longer time to progression on combined trastuzumab-chemotherapy when first treated with trastuzumab monotherapy ( P =0.02). Monitoring HER2 ECD levels during the course of the trial revealed significant time ( P =0.001) and time-treatment arm interactions ( P =0.0007). Under upfront trastuzumab alone, the HER2 ECD levels remained stable until just before disease progression. In patients responding to combination treatment HER2 ECD levels decreased to > 20%.
Conclusions
Plasma HER2 ECD levels in patients with metastatic breast cancer reflect HER2 disease status. This robust biomarker might help identifying patients without visceral disease profiting from a sequential treatment’s modality. Monitoring HER2 ECD levels during trastuzumab monotherapy could help defining the optimal time to introduce chemotherapy.
Co-overexpression of STIP1 and Hsp90 correlates with progression and prognosis of lung adenocarcinoma
Authors: Zhang Youwen , Wang Junye , Ye Shucheng , Guo Maoqing , Jiang Shenghua , Li Wei 
Published: January 2020

Abstract
Background: Stress-inducible phosphoprotein 1 (STIP1) and heat shock protein 90 (Hsp90) have been found to be correlated with malignant tumors. The aim of this study was to analyze the relationship between their expressions and lung adenocarcinoma (LAC).
Methods: The expressions of STIP1 and Hsp90 in LAC cells and tissues were tested by immunohistochemistry and western blot; the correlation between their expressions and clinicopathological parameters of LAC was analyzed by survival analysis and multiple regression analysis.
Results: The expressions of STIP1 and Hsp90 were higher in A549 cells and LAC tissues than that in 16 human bronchial epithelial cells (16HBE cells) (P < 0.05) and cancer-adjacent normal lung tissues (P < 0.05). The expressions of STIP1 and Hsp90 in LAC showed a strong positive correlation (P < 0.05) and the increased expressions of STIP1 and Hsp90 significantly correlated with lymph node metastasis (P < 0.05), advanced clinical stage (P < 0.05) and shorter survival (P < 0.05) of LAC.
Conclusions: The increased expressions of STIP1 and Hsp90 were closely related to malignant biological behavior of LAC, indicating that they could be used as the potential biomarkers and prognostic indicators for LAC.
A Probabilistic Approach for Economic Evaluation of Occupational Health and Safety Interventions: A Case Study of Silica Exposure Reduction Interventions in the Construction Sector
Authors: Mofidi Amirabbas , Tompa Emile , Mortazavi SeyedBagher , Esfahanipour Akbar , Demers Paul A. 
Published: January 2020

Abstract

Background: Construction workers are at a high risk of exposure to various types of hazardous substances such as crystalline silica. Though multiple studies indicate the evidence regarding the effectiveness of different silica exposure reduction interventions in the construction sector, the decisions for selecting a specific silica exposure reduction intervention are best informed by an economic evaluation. Economic evaluation of interventions is subjected to uncertainties in practice, mostly due to the lack of precise data on important variables. In this study, we aim to identify the most cost-beneficial silica exposure reduction intervention for the construction sector under uncertain situation. Methods: We apply a probabilistic modeling approach that covers a large number of variables relevant to the cost of lung cancer, as well as the costs of silica exposure reduction interventions. To estimate the societal lifetime cost of lung cancer, we use an incidence cost approach. To estimate the net benefit of each intervention, we compare the expected cost of lung cancer cases averted, with expected cost of implementation of the intervention in one calendar year. Sensitivity analysis is used to quantify how different variables effects interventions net benefit. Results: A positive net benefit is expected for all considered interventions. The highest number of lung cancer cases are averted by combined use of wet method, local exhaust ventilation and personal protective equipment, about 107 cases, with expected net benefit of $45.9 million. Results also suggest that the level of exposure is an important determinant for the selection of the most cost-beneficial intervention. Conclusions: This study provides important insights for decision makers about silica exposure reduction interventions in the construction sector. It also provides an overview of the potential advantages of using probabilistic modeling approach to undertake economic evaluations, particularly when researchers are confronted with a large number of uncertain variables.
Genome-wide analysis of long non-coding RNAs (lncRNAs) in two contrasting rapeseed (Brassica napus L.) genotypes subjected to drought stress and re-watering
Authors: Tan Xiaoyu , Li Su , Hu Liyong , Zhang Chunlei 
Published: January 2020

Abstract
Background: Drought stress is a major abiotic factor that affects rapeseed ( Brassica napus L.) productivity. Though previous studies indicated that long non-coding RNAs (lncRNAs) play a key role in response to drought stress, a scheme for genome-wide identification and characterization of lncRNAs’ response to drought stress is still lacking, especially in the case of B . napus . In order to further understand the molecular mechanism of the response of B . napus to drought stress, we compared changes in the transcriptome between Q2 (a drought-tolerant genotype) and Qinyou8 (a drought-sensitive genotype) in response to drought stress and rehydration treatment at the seedling stage.

Results: A total of 5,546 down-regulated and 6,997 up-regulated mRNAs were detected in Q2 compared with 7,824 and 10,251 in Qinyou8, respectively; 369 down-regulated and 108 up-regulated lncRNAs were detected in Q2 compared with 449 and 257 in Qinyou8, respectively. LncRNA- mRNA interaction network analysis indicated that the co-expression network of Q2 was composed of 145 network nodes and 5,175 connections, while the co-expression network of Qinyou8 was composed of 305 network nodes and 22,327 connections. We further identified 34 TFs corresponding to 126 differentially expressed lncRNAs in Q2, and 45 TFs corresponding to 359 differentially expressed lncRNAs in Qinyou8. Differential expression analysis of lncRNAs indicated that up- and down-regulated mRNAs co-expressed with lncRNAs participated in different metabolic pathways and were involved in different regulatory mechanisms in the two genotypes . Notably, some lncRNAs were co-expressed with BnaC07g44670D, which are associated with plant hormone signal transduction. Additionally, some mRNAs which were co-located with XLOC_052298, XLOC_094954 and XLOC_012868 were mainly categorized as signal transport and defense/stress response.

Conclusions: The results of this study increased our understanding of expression characterization of rapeseed lncRNAs in response to drought stress and re-watering, which would be useful to provide a reference for the further study of the function and action mechanisms of lncRNAs under drought stress and re-watering.
Prioritising pathogens for the management of severe febrile patients to improve clinical care in low- and middle-income countries
Authors: Osborn Jennifer , Roberts Teri , Guillen Ethan , Bernal Oscar , Roddy Paul , Ongarello Stefano , Sprecher Armand , Page Anne-Laure , Ribeiro Isabela , Piriou Erwan , Tamrat Abiy , Tour Roberto de la , Rao V. Bhargavi , Flevaud Laurence , Jensen Tomas , McIver Lachlan , Kelly Cassandra , Dittrich Sabine 
Published: January 2020

Abstract
Background: Severe febrile illness without a known source (SFWS) is a challenge for clinicians when deciding how to manage a patient, particularly given the wide spectrum of potential aetiologies that contribute to fever. These infections are difficult to distinguish clinically, and accurate diagnosis requires a plethora of diagnostics including blood cultures, imaging techniques, molecular or serological tests, and more. When laboratory services are available, a limited test menu hinders clinical decision-making and antimicrobial stewardship, leading to empiric treatment and suboptimal patient outcomes. To specifically address SFWS, this work aimed to identify priority pathogens for a globally applicable panel for fever causing pathogens.

Method: A pragmatic two-pronged approach combining currently available scientific data in an analytical hierarchy process and systematically gathered expert input, was designed to address the lack of comprehensive global aetiology data. The expert re-ranked list was then further adapted for a specific use case to focus on community acquired infections in whole blood specimens. The resulting list was further analysed to address different geographical regions (Asia, Africa, and Latin America), and Cohen kappa scores of agreement were calculated.

Results: The expert ranked prioritized pathogen list generated as part of this two-pronged approach included typhoidal Salmonella , Plasmodium species and Mycobacterium tuberculosis as the top 3 pathogens. This pathogen list was then further adapted for the SFWS use case to develop a final pathogen list to inform product development. Subsequent analysis comparing the relevance of the SFWS pathogen list to multiple populations and geographical regions showed that the SFWS prioritized list had considerable utility across Africa and Asia, but less so for Latin America. In addition, the list showed high levels of agreement across different patient sub-populations, but lower relevance for neonates and symptomatic HIV patients.

Conclusion: This work highlighted once again the challenges of prioritising in global health, but it also shows that taking a two-pronged approach, including the actionability, can result in a broadly applicable priority list. This broad utility is particularly important in the context of product development, where a sufficient market size is essential to achieve a sustainable commercialized diagnostic product to address SFWS.
Lapatinib in combination with capecitabine versus continued use of trastuzumab in breast cancer patients with trastuzumab-resistance: a retrospective study of a Chinese population.
Authors: Yang fan , Huang Xiang , Sun Chunxiao , Li Jianbin , Wang Biyun , Yan Min , Jin Feng , Wang Haibo , Zhang Jin , Fu Peifen , Zeng Tianyu , Wang Jian , Li Wei , Li Yongfei , Yang Mengzhu , Li Jun , Wu Hao , Fu Ziyi , Yin Yongmei , jiang zefei 
Published: January 2020

Abstract
Background: The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab plus chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to trastuzumab is unknown.
Methods: We retrospectively analyzed data from breast cancer patients who began treatment with regimens of lapatinib plus capecitabine (LC or LX) or trastuzumab beyond progression (TBP) at eight hospitals between May 2010 and October 2017.
Results: Among 554 patients who had developed resistance to trastuzumab, the median PFS (progression free survival) was 6.77 months in the LX group compared with 5.6 months in the TBP group (hazard ratio 0.804; 95% CI, 0.67 to 0.96; P=0.019). The central nervous system progression rate during treatment was 5.9% in the LX group and 12.5% in the TBP group (P=0.018).
Conclusion: The combination of lapatinib and capecitabine showed a prolonged PFS relative to TBP in patients who had progressed on trastuzumab.
The DELLA Proteins Interact with MYB21 and MYB24 to Regulate Filament Elongation in Arabidopsis
Authors: Huang Huang , Gong Yilong , Liu Bei , Wu Dewei , Zhang Min , Xie Daoxin , Song Susheng 
Published: January 2020

Abstract
Background: Gibberellin (GA) and jasmonate (JA) are two essential phytohormones for filament elongation in Arabidopsis . GA and JA trigger degradation of DELLAs and JASMONATE ZIM-domain (JAZ) proteins through SCF SLY1 and SCF COI1 separately to activate filament elongation . In JA pathway, JAZs interact with MYB21 and MYB24 to control filament elongation. However, little is known how DELLAs regulate filament elongation.
Results: Here we showed that DELLAs interact with MYB21 and MYB24, and that R2R3 domains of MYB21 and MYB24 are responsible for interaction with DELLAs. Furthermore, we demonstrated that DELLA and JAZ proteins coordinately repress the transcriptional function of MYB21 and MYB24 to inhibit filament elongation .
Conclusion: We discovered that DELLAs interact with MYB21 and MYB24, and that DELLAs and JAZs attenuate the transcriptional function of MYB21 and MYB24 to control filament elongation. This study reveals a novel cross-talk mechanism of GA and JA in the regulation of filament elongation in Arabidopsis .
Keywords: Gibberellin, Jasmonate, MYB21, MYB24, Filament elongation
A survey of seasonal and perennial allergic conjunctivitis in children in southwest China: a case-control study
Authors: Gao Xu , Tang Xiaojiao , Xiang Qin 
Published: January 2020

Abstract
Background: Seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) were the most usual types of allergic conjunctivitis. House dust mites were the most common sensitization agents for SAC and PAC. This study aimed to explore SAC and PAC risk factors in children. Methods：We recruited 176 children suffering from SAC or PAC and 131 control subjects in southwest China. A questionnaire was provided to all the subjects’ parents. Several eye exams were performed, and all the subjects received the skin prick test (SPT). We analyzed the questionnaire data, the scores of the symptoms/signs and the SPT results. Results: The percentage of children that had ever been breastfed in the case group was lower than in the control group (P<0.05). The rate of parental allergy history in the case group was higher than for the control group (P<0.01). Compared with the control group, the case group was more likely to have other systemic allergic diseases (P<0.01). Some children in case group had adenoidal hypertrophy (ATH), and incidence rate was different from control group (P<0.05). The ocular symptoms and signs scores had significant correlation to the clinical course (P<0.05), but there was no correlation to the SPT results (P>0.05). Conclusion: Allergic conjunctivitis may coexist with a variety of allergic diseases, and SAC and PAC may be a risk factor for ATH. Breastfeeding should be recommended, as it may be an alleviating factor for allergic diseases, especially for children of parents with a history of allergic diseases. The disease severity is closely related to its course. Therefore, to avoid difficulty in treatment caused by the aggravation of symptoms and signs, timely antiallergic treatment was recommended.