bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunotherapy for squamous cell carcinoma of the head and neck
Authors: Yokota Tomoya , Homma Akihiro , Kiyota Naomi , Tahara Makoto , Hanai Nobuhiro , Asakage Takahiro , Matsuura Kazuto , Ogawa Takenori , Saito Yuki , Sano Daisuke , Kodaira Takeshi , Motegi Atsushi , Yasuda Koichi , Takahashi Shunji , Tanaka Kaoru , Onoe Takuma , Okano Susumu , Imamura Yoshinori , Ariizumi Yosuke , Hayashi Ryuichi ,   Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group
Published: July 2020

Abstract
Squamous cell carcinoma of the head and neck is characterized by an immunosuppressive environment and evades immune responses through multiple resistance mechanisms. A breakthrough in cancer immunotherapy employing immune checkpoint inhibitors has evolved into a number of clinical trials with antibodies against programmed cell death 1 (PD-1), its ligand PD-L1 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) for patients with squamous cell carcinoma of the head and neck. CheckMate141 and KEYNOTE-048 were practice-changing randomized phase 3 trials for patients with platinum-refractory and platinum-sensitive recurrent or metastatic squamous cell carcinoma of the head and neck, respectively. Furthermore, many combination therapies using anti-CTLA-4 inhibitors, tyrosine kinase inhibitors and immune accelerators are currently under investigation. Thus, the treatment strategy of recurrent or metastatic squamous cell carcinoma of the head and neck is becoming more heterogeneous and complicated in the new era of individualized medicine. Ongoing trials are investigating immunotherapeutic approaches in the curative setting for locoregionally advanced disease. This review article summarizes knowledge of the role of the immune system in the development and progression of squamous cell carcinoma of the head and neck, and provides a comprehensive overview on the development of immunotherapeutic approaches in both recurrent/metastatic and locoregionally advanced diseases.
Internet-Delivered Acceptance and Commitment Therapy for Adolescents with Chronic Pain and Their Parents: A Nonrandomized Pilot Trial
Authors: Zetterqvist Vendela , Gentili Charlotte , Rickardsson Jenny , Sörensen Isabel , Wicksell Rikard K 
Published: July 2020

AbstractBackgroundAcceptance and Commitment Therapy (ACT) is an empirically supported treatment for chronic pain in adults. There is also a small but growing evidence base of ACT for pediatric chronic pain. However, because of limited access to psychological treatment for pain, and geographical distances from pain facilities, many patients will not receive such treatment.ObjectiveThe aim of the study was to evaluate the feasibility and preliminary effects of an internet-delivered ACT for adolescents with chronic pain, and their parents.MethodsIn this nonrandomized pilot study 28 self-recruited adolescents, aged 13–17 years, received 8 weeks of internet-delivered ACT, while outcomes were assessed at pre-, posttreatment, and at follow-up (17–25 weeks). Parents of the adolescents received an 8-week internet-delivered parental program, and their outcomes were assessed at the same timepoints. Both treatments were guided by a therapist experienced in ACT and chronic pain.ResultsSome threats to feasibility were identified such as slow recruitment rate, low compliance and a delay in completion of follow-up assessments. Preliminary outcome evaluation showed that adolescents showed a large significant improvement on their main outcome (pain interference, d = 1.09), and parents a medium improvement on their main outcome, pain reactivity (d = 0.70). Improvements were also seen in adolescents’ depressive symptoms and insomnia severity.ConclusionThe preliminary results of internet-delivered ACT are promising with regards to improvements in adolescent and parent outcome. Measures to improve feasibility are needed prior to conducting a larger randomized trial.
Deletion of maize RDM4 suggests a role in endosperm maturation as well as vegetative and stress-responsive growth
Authors: Jia Shangang , Yobi Abou , Naldrett Michael J , Alvarez Sophie , Angelovici Ruthie , Zhang Chi , Holding David R 
Published: July 2020

Abstract
Opaque kernels in maize may result from mutations in many genes, such as OPAQUE-2. In this study, a maize null mutant of RNA-DIRECTED DNA METHYLATION 4 (RDM4) showed an opaque kernel phenotype, as well as plant developmental delay, male sterility, and altered response to cold stress. We found that in opaque kernels, all zein proteins were reduced and amino acid content was changed, including increased lysine. Transcriptomic and proteomic analysis confirmed the zein reduction and proteomic rebalancing of non-zein proteins, which was quantitatively and qualitatively different from opaque-2. Global transcriptional changes were found in endosperm and leaf, including many transcription factors and tissue-specific expressed genes. Furthermore, of the more than 8000 significantly differentially expressed genes in wild type in response to cold, a significant proportion (25.9% in moderate cold stress and 40.8% in near freezing stress) were not differentially expressed in response to cold in rdm4, suggesting RDM4 may participate in regulation of abiotic stress tolerance. This initial characterization of maize RDM4 provides a basis for further investigating its function in endosperm and leaf, and as a regulator of normal and stress-responsive development.
SBAR as a Standardized Communication Tool for Medical Laboratory Science Students
Authors: Oliveira Ana L , Brown Michelle 
Published: July 2020

Abstract

Objective
Laboratory professionals must communicate effectively on an interprofessional team. It is the responsibility of Medical Laboratory Science (MLS) programs to teach communication. The structured communication tool Situation, Background, Assessment, and Recommendation (SBAR) is one way to promote effective communication.

Methods
Students participated in a case-based simulation activity on the importance of teamwork/communication and the use of SBAR and completed a pre/post survey on communicating interprofessionally.

Results
Students reported increased confidence and competence with interprofessional communication after the activity with 4 of 5 questions demonstrating a statistically significant increase in scores post SBAR instruction.

Conclusions
Our study demonstrates that SBAR is a suitable communication tool that can be used to increase our MLS students’ confidence and competency in interprofessional communication. Educators should use this communication tool to empower MLS students to be effective members of the healthcare team.
Phase-locked polarization by photospheric reflection in the semidetached eclipsing binary μ1 Sco
Authors: Cotton Daniel V , Bailey Jeremy , Kedziora-Chudczer Lucyna , De Horta Ain 
Published: July 2020

ABSTRACT
We report the detection of phase-locked polarization in the bright (mV = 2.98−3.24) semidetached eclipsing binary μ1 Sco (HD 151890). The phenomenon was observed in multiple photometric bands using two different HIPPI-class (HIgh Precision Polarimetric Instrument) polarimeters with telescopes ranging in size from 35 cm to 3.9 m. The peak-to-trough amplitude of the polarization is wavelength dependent and large, ∼700 ppm in green light, and is easily seen with even the smallest telescope. We fit the polarization phase curve with a synspec/vlidort polarized radiative transfer model and a Wilson–Devinney geometric formalism, which we describe in detail. Light from each star reflected by the photosphere of the other, together with a much smaller contribution from tidal distortion and eclipse effects, wholly accounts for the polarization amplitude. In the past, polarization in semidetached binaries has been attributed mostly to scattering from extra-stellar gas. Our new interpretation facilitates determining masses of such stars in non-eclipsing systems.
CO-to-H2 conversion and spectral column density in molecular clouds: the variability of the XCO factor
Authors: Sofue Yoshiaki , Kohno Mikito 
Published: July 2020

ABSTRACT
Analysing the Galactic plane CO survey with the Nobeyama 45-m telescope, we compared the spectral column density (SCD) of $N_{\rm H_2}$ calculated for the 12CO (J = 1–0) line using the current conversion factor $X_{\rm ^{12}CO}$ to that for the 13CO (J = 1–0) line under the LTE (local thermal equilibrium) assumption in the M16 and W43 regions. Here, SCD is defined by $\mathrm{d}N_{\rm H_2}/\mathrm{d}v$ with $N_{\rm H_2}$ and v being the column density and radial velocity, respectively. It is found that the $X_{\rm ^{12}CO}$ method significantly underestimates the H2 density in a cloud or region, where SCD exceeds a critical value (∼3 × 1021 [H2 cm−2 (km s−1)−1]), but overestimates in lower SCD regions. We point out that the actual CO-to-H2 conversion factor varies with the H2 column density or with the CO line intensity: it increases in the inner and opaque parts of molecular clouds, whereas it decreases in the low-density envelopes. However, in so far as the current $X_{^{12}{\rm CO}}$ is used combined with the integrated 12CO intensity averaged over an entire cloud, it yields a consistent value with that calculated using the 13CO intensity by LTE. Based on the analysis, we propose a new CO-to-H2 conversion relation, $N_{\rm H_2}^* = \int X^*_{\rm CO} (T_{\rm B}) T_{\rm B}\ \mathrm{d}v$, where $X^*_{\rm CO} (T_{\rm B})=(T_{\rm B}/T_{\rm B}^*)^\beta X_{\rm ^{12}CO}$ is the modified spectral conversion factor as a function of the brightness temperature, TB, of the 12CO (J = 1–0) line, and β ∼ 1–2 and $T_{\rm B}^*=12\!-\!16$ K are empirical constants obtained by fitting to the observed data. The formula corrects for the over/underestimation of the column density at low/high CO line intensities, and is applicable to molecular clouds with TB ≥ 1 K (12CO (J = 1–0) line rms noise in the data) from envelope to cores at sub-parsec scales (spatial resolution).
Systematic investigation of the effect of 56Ni mixing in the early photospheric velocity evolution of stripped-envelope supernovae
Authors: Moriya Takashi J , Suzuki Akihiro , Takiwaki Tomoya , Pan Yen-Chen , Blinnikov Sergei I 
Published: July 2020

ABSTRACT
Mixing of 56Ni, whose nuclear decay energy is a major luminosity source in stripped-envelope supernovae, is known to affect the observational properties of stripped-envelope supernovae such as light-curve and colour evolution. Here we systematically investigate the effect of 56Ni mixing on the photospheric velocity evolution in stripped-envelope supernovae. We show that 56Ni mixing significantly affects the early photospheric velocity evolution. The photospheric velocity, which is often used to constrain the ejecta mass and explosion energy, significantly varies by just changing the degree of 56Ni mixing. In addition, the models with a small degree of 56Ni mixing show a flattening in the early photospheric velocity evolution, while the fully mixed models show a monotonic decrease. The velocity flattening appears in both helium and carbon+oxygen progenitor explosions with a variety of ejecta mass, explosion energy, and 56Ni mass. Some stripped-envelope supernovae with early photospheric velocity information do show such a flattening. We find that Type Ib SN 2007Y, which has early photospheric velocity information, has a signature of a moderate degree of 56Ni mixing in the photospheric velocity evolution and about half of the ejecta is mixed in it. The immediate spectroscopic follow-up observations of stripped-envelope supernovae shortly after the explosion providing the early photospheric evolution give an important clue to constrain 56Ni mixing in the ejecta.
Towards understanding physical origin of 2175 Å extinction bump in interstellar medium
Authors: Ma Xing-Yu , Zhu Yan-Yan , Yan Qing-Bo , You Jing-Yang , Su Gang 
Published: July 2020

ABSTRACT
The 2175 Å ultraviolet (UV) extinction bump in interstellar medium (ISM) of the Milky Way was discovered in 1965. After intensive exploration of more than a half century, however, its exact origin still remains a big conundrum that is being debated. Here, we propose a mixture model by which the extinction bump in ISM is argued possibly relevant to the clusters of hydrogenated T-carbon (HTC) molecules (C40H16) that have intrinsically a sharp absorption peak at the wavelength 2175 Å. By linearly combining the calculated absorption spectra of HTC mixtures, graphite, MgSiO3, and Fe2SiO4, we show that the UV extinction curves of optional six stars can be nicely fitted. This work poses an alternative explanation towards understanding the physical origin of the 2175 Å extinction bump in ISM of the Milky Way.
DropSynth 2.0: high-fidelity multiplexed gene synthesis in emulsions
Authors: Sidore Angus M , Plesa Calin , Samson Joyce A , Lubock Nathan B , Kosuri Sriram 
Published: July 2020

Abstract
Multiplexed assays allow functional testing of large synthetic libraries of genetic elements, but are limited by the designability, length, fidelity and scale of the input DNA. Here, we improve DropSynth, a low-cost, multiplexed method that builds gene libraries by compartmentalizing and assembling microarray-derived oligonucleotides in vortexed emulsions. By optimizing enzyme choice, adding enzymatic error correction and increasing scale, we show that DropSynth can build thousands of gene-length fragments at &gt;20% fidelity.
H/ACA snoRNA levels are regulated during stem cell differentiation
Authors: McCann Kathleen L , Kavari Sanam L , Burkholder Adam B , Phillips Bart T , Hall Traci M Tanaka 
Published: July 2020

Abstract
H/ACA small nucleolar RNAs (snoRNAs) guide pseudouridylation as part of a small nucleolar ribonucleoprotein complex (snoRNP). Disruption of H/ACA snoRNA levels in stem cells impairs pluripotency, yet it remains unclear how H/ACA snoRNAs contribute to differentiation. To determine if H/ACA snoRNA levels are dynamic during differentiation, we comprehensively profiled H/ACA snoRNA abundance in multiple murine cell types and during differentiation in three cellular models, including mouse embryonic stem cells and mouse myoblasts. We determined that the profiles of H/ACA snoRNA abundance are cell-type specific, and we identified a subset of snoRNAs that are specifically regulated during differentiation. Additionally, we demonstrated that a decrease in Snora27 abundance upon differentiation corresponds to a decrease in pseudouridylation of its target site within the E-site transfer RNA (tRNA) binding region of the 28S ribosomal RNA (rRNA) in the large ribosomal subunit. Together, these data point toward a potential model in which H/ACA snoRNAs are specifically regulated during differentiation to alter pseudouridylation and fine tune ribosome function.
The science of consciousness does not need another theory, it needs a minimal unifying model
Authors: Wiese Wanja 
Published: July 2020

Abstract
This article discusses a hypothesis recently put forward by Kanai et al., according to which information generation constitutes a functional basis of, and a sufficient condition for, consciousness. Information generation involves the ability to compress and subsequently decompress information, potentially after a temporal delay and adapted to current purposes. I will argue that information generation should not be regarded as a sufficient condition for consciousness, but could serve as what I will call a “minimal unifying model of consciousness.” A minimal unifying model (MUM) specifies at least one necessary feature of consciousness, characterizes it in a determinable way, and shows that it is entailed by (many) existing theories of consciousness. Information generation fulfills these requirements. A MUM of consciousness is useful, because it unifies existing theories of consciousness by highlighting their common assumptions, while enabling further developments from which empirical predictions can be derived. Unlike existing theories (which probably contain at least some false assumptions), a MUM is thus likely to be an adequate model of consciousness, albeit at a relatively general level. Assumptions embodied in such a model are less informative than assumptions made by more specific theories and hence function more in the way of guiding principles. Still, they enable further refinements, in line with new empirical results and broader theoretical and evolutionary considerations. This also allows developing the model in ways that facilitate more specific claims and predictions.
Long-Term Disease Burden and Survivorship Issues After Surgery and Radiotherapy of Intracranial Meningioma Patients
Authors: Zamanipoor Najafabadi Amir H , van der Meer Pim B , Boele Florien W , Taphoorn Martin J B , Klein Martin , Peerdeman Saskia M , van Furth Wouter R , Dirven Linda ,   Dutch Meningioma Consortium Moojen Wouter A MD, PhD University Neurosurgical Centre Holland, Leiden University Medical Centre, Haaglanden Medical Centre and Haga Teaching Hospital, Leiden and The Hague, the Netherlands Reijneveld Jaap C MD, PhD Brain Tumor Center Amsterdam at Amsterdam University Medical Centers, location VUmc, Amsterdam, the Netherlands Department of Neurology, Amsterdam University Medical Centers, location VUmc, Amsterdam, the Netherlands, Moojen Wouter A , Reijneveld Jaap C 
Published: July 2020

Abstract

BACKGROUND
Many intracranial meningioma patients have an impaired health-related quality of life (HRQoL) and neurocognitive functioning up to 4 yr after intervention.

OBJECTIVE
To assess the long-term (≥5 yr) disease burden of meningioma patients.

METHODS
In this multicenter cross-sectional study, patients ≥5 yr after intervention (including active magnetic resonance imaging (MRI) surveillance) were included and assessed for HRQoL (Short-Form Health Survey 36), neurocognitive functioning (neuropsychological assessment), anxiety and depression (Hospital Anxiety and Depression Scale), and work productivity (Short Form-Health and Labour Questionnaire). Multivariable and propensity score regression analyses were used to compare patients and controls, and different treatment strategies corrected for possible confounders. Clinically relevant differences were reported.

RESULTS
At a median of 9 yr follow-up after intervention, meningioma patients (n = 190) reported more limitations due to physical (difference 12.5 points, P = .008) and emotional (13.3 points, P = .002) health problems compared with controls. Patients also had an increased risk to suffer from anxiety (odds ratio [OR]: 2.6, 95% CI: 1.2-5.7) and depression (OR: 3.7, 95% CI: 1.3-10.5). Neurocognitive deficits were found in 43% of patients. Although postoperative complications, radiotherapy, and reresection were associated with worse verbal memory, attention, and executive functioning when compared to patients resected once, the only clinically relevant association was between reresection and worse attention (–2.11, 95% CI: –3.52 to –0.07). Patients of working age less often had a paid job (48%) compared with the working-age Dutch population (72%) and reported more obstacles at work compared with controls.

CONCLUSION
In the long term, a large proportion of meningioma patients have impaired HRQoL, neurocognitive deficits, and high levels of anxiety or depression. Patients treated with 1 resection have the best neurocognitive functioning.
Systematic literature review of non-topical treatments for early, untreated (systemic therapy naïve) psoriatic disease: a GRAPPA initiative
Authors: De Marco Gabriele , Berekméri Anna , Coates Laura C , Dubash Sayam , Emmel Jenny , Gladman Dafna D , Lubrano Ennio , McGonagle Dennis G , Mahmood Farrouq , Marchesoni Antonio , Mason Laura , Ogdie Alexis , Wittmann Miriam , Helliwell Philip S , Marzo-Ortega Helena 
Published: July 2020

AbstractBackgroundPsoriatic disease (PsD) is a complex systemic disorder with cutaneous and musculoskeletal manifestations. Current evidence on pharmacological interventions, effective across the spectrum of clinical manifestations of early, systemic treatment-naïve PsD, is limited. This review aims to appraise such evidence.MethodsThis systematic review examined seven patient–intervention–comparator–outcome research questions to address the efficacy of the interventions on the following: across the spectrum of clinical manifestations PsD activity; peripheral arthritis; dactylitis; spondylitis; enthesitis; skin; and nails. Early PsD was defined as a disease duration of ≤2 years, except for studies investigating outcomes restricted to the skin. Eligible references were clinical trials or well-designed prospective studies/series reporting on adult humans, untreated, with cutaneous and/or musculoskeletal features of PsD.ResultsNine references (out of 160 319, publication range 1946–2019) fulfilled the eligibility criteria. No study adopted comprehensive (that is, simultaneous assessment of different PsD manifestations) composite indices as primary outcome measures. Individual studies reported that apremilast and biologics successfully improved outcomes (disease activity index for PsA, minimal disease activity, PsA DAS, psoriasis area and severity index, PsA response criteria) when efficacy analyses were restricted to single manifestations of untreated PsD. Only qualitative synthesis of evidence was possible, owing to the following factors: data heterogeneity (disease classification criteria, outcome measures); unavailable data subsets (focused on early, untreated PsD) at the single study level; and insufficient data on the exposure of participants to previous treatment.ConclusionEffective interventions, albeit limited in scope, were found for early, treatment-naïve PsD. No study provided evidence about the management of co-occurring cutaneous and musculoskeletal manifestations in early, treatment-naïve PsD. This review highlights an unmet need in research on early PsD.
DNMT1-mediated Foxp3 gene promoter hypermethylation involved in immune dysfunction caused by arsenic in human lymphocytes
Authors: Ma Yemei , Ye Ying , Liu Yining , Chen Jing , Cen Yanli , Chen Wenyan , Yu Chun , Zeng Qibing , Zhang Aihua , Yang Guanghong 
Published: July 2020

Abstract
Growing evidence indicates that arsenic can cause long-lasting and irreversible damage to the function of the human immune system. It is known that forkhead box protein 3(Foxp3), which is specifically expressed in regulatory T cells (Tregs), plays a decisive role in immunoregulation and is regulated by DNA methylation. While evidence suggests that epigenetic regulated Foxp3 is involved in the immune disorders caused by arsenic exposure, the specific mechanism remains unclear. In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes. Treatment with DNA methyltransferase inhibitor 5-Aza-CdR can notably inhibit the expression of DNMT1, effectively restoring the hypermethylation of the Foxp3 promoter region in primary human lymphocytes and upregulating the expression levels of Foxp3, balancing the ratio of CD4+/CD8+ T cells in lymphocytes. It also activates the secretion of anti-inflammatory cytokines and restores the immune regulatory functions of Tregs. In conclusion, our study provides limited evidence that DNMT1-mediated Foxp3 gene promoter hypermethylation is involved in immune dysfunction caused by arsenic in primary human lymphocytes. The study can provide a scientific basis for further understanding the arsenic-induced immune dysfunction in primary human lymphocytes.