bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting poor outcomes and the need for surgical treatment in neonates with meconium peritonitis
Authors: Feng Yan , Zheng Haiqing , Zhang Guanglan , Zhong Wei , Guo Kaimin , Tang Haiyang , Zhong Junmin , Yin Wei , Wang Zhe , Mei Shanshan , Morse Abraham N. 
Published: November 2019

AbstractObjectiveThe objective of this study is to determine factors associated with poor outcomes and the need for surgical treatment in neonates with meconium peritonitis (MP).MethodsWe evaluated the association between prenatal ultrasound features, maternal characteristics, and the likelihood of surgery, mortality, and serious morbidity in 49 neonates with a prenatal diagnosis of MP, who were born in Guangzhou Women and Children's Medical Center between January 2011 and December 2016.ResultsThirty of 49 neonates (61.2%) required surgical treatment, and 17 (34.7%) had a poor outcome. Independent predictors of need for surgical treatment were polyhydramnios, maternal intrahepatic cholestasis of pregnancy (associated with lower risk), and persistence of peritoneal fluid. The model correctly predicted 70.0% of the neonates who required surgery (at a 10% false‐positive rate; area under the curve [AUC]: 0.86 [95% CI, 0.75‐0.97]). For poor outcomes, independent predictors were low gestational age at birth, persistence of peritoneal fluid, and polyhydramnios. For the latter, the model only achieved a detection rate of 52.9% (10% false‐positive rate, AUC: 0.82 [95% CI, 0.70‐0.94]).ConclusionsA combination of prenatal ultrasound features and maternal characteristics correctly predicted 70.0% the need for neonatal surgery. Prediction of poor outcome‐based prenatal ultrasound features and gestational age did not perform well.
Overview of assessment for deaf and hard of hearing students
Authors: Neild Raschelle , Fitzpatrick Michael 
Published: November 2019

AbstractHistorically assessing deaf and hard of hearing (D/HH) students has been a daunting challenge. Although significant strides have been made, there continues to be a dearth of research and literature specifically addressing the endemic challenges multidisciplinary teams encounter when assessing D/HH students. This article delineates a historical overview, purpose of assessment, student‐centered approaches, limitations and challenges, and appropriate protocols for assessing D/HH students.
Feasibility and acceptability of a pilot tailored text messaging intervention for adolescents and young adults completing cancer treatment
Authors: Schwartz Lisa A. , Daniel Lauren C. , Henry‐Moss Dare , Bonafide Christopher P. , Li Yimei , Psihogios Alexandra M. , Butler Eliana S. , Szalda Dava , Ver Hoeve Elizabeth S. , Hobbie Wendy L. , Dowshen Nadia L. , Pierce Lisa , Kersun Leslie S. , Barakat Lamia P. 
Published: November 2019

AbstractPurposeDespite cure, adolescents and young adults (AYA) who complete cancer treatment remain at risk for numerous physical and psychological late effects. However, engagement in recommended follow‐up care, knowledge of cancer treatment history and risks, and adoption of health promoting behaviors are often suboptimal. The pilot randomized controlled trial assessed the feasibility and acceptability of a text messaging intervention (THRIVE; Texting Health Resources to Inform, motiVate, and Engage) designed to promote well‐being, and health knowledge and behaviors.MethodsSixty‐one AYA who recently completed cancer therapy enrolled and were randomized to receive THRIVE (n = 31) or an AYA survivor handbook (n = 30). Participants from both groups completed baseline measures and follow‐up surveys 16 weeks later. AYA randomized to THRIVE received one to two health‐related text messages per day over 16 weeks.ResultsTHRIVE demonstrated a high level of acceptability and feasibility. Exploratory analyses highlighted promising improvements in knowledge, fruit/vegetable intake, and perceptions of health vulnerability.ConclusionsText messaging is an acceptable and feasible intervention approach for improving well‐being and health of AYA survivors. Future research is needed to test the impact of text messaging in a larger trial, including whether or not such an intervention can improve clinical outcomes, such as survivors' engagement in follow‐up care.
Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL‐1 signaling pathway
Authors: Balázs Anita , Mall Marcus A. 
Published: November 2019

AbstractMucus plugging constitutes a nutrient‐rich nidus for a bacterial infection that has long been recognized as a potent stimulus for neutrophilic airway inflammation driving progressive lung damage in people with cystic fibrosis (CF). However, mucus plugging and neutrophilic inflammation are already present in many infants and young children with CF even in the absence of detectable bacterial infection. A series of observational studies in young children with CF, as well as investigations in animal models with CF‐like lung disease support the concept that mucus plugging per se can trigger inflammation before the onset of airways infection. Here we review emerging evidence suggesting that activation of the interleukin‐1 (IL‐1) signaling pathway by hypoxic epithelial cell necrosis, leading to the release of IL‐1α in mucus‐obstructed airways, may be an important mechanistic link between mucus plugging and sterile airway inflammation in early CF lung disease. Furthermore, we discuss recent data from preclinical studies demonstrating that treatment with the IL‐1 receptor (IL‐1R) antagonist anakinra has anti‐inflammatory as well as mucus modulating effects in mice with CF‐like lung disease and primary cultures of human CF airway epithelia. Collectively, these studies support an important role of the IL‐1 signaling pathway in sterile neutrophilic inflammation and mucus hypersecretion and suggest inhibition of this pathway as a promising anti‐inflammatory strategy in patients with CF and potentially other muco‐obstructive lung diseases.
Off‐label use of intravenous antimicrobials for inhalation in patients with cystic fibrosis
Authors: McKinzie Cameron J. , Chen Lori , Ehlert Kim , Grisso Alison G. , Linafelter Alaina , Lubsch Lisa , O'Brien Catherine E. , Pan Alice C. , Wright Brittany A. , Elson E. Claire 
Published: November 2019

AbstractManagement of infections in patients with cystic fibrosis (CF) presents challenges for healthcare providers, including the eradication of initial acquisition, treatment of acute exacerbations, and chronic infection with suppressive therapy. Inhaled antimicrobial therapy for infections in patients with CF has been used in these capacities, often in an effort to achieve optimal concentrations in sputum for antimicrobial efficacy while mitigating potential toxicities associated with systemic therapy. Unfortunately, there are few commercially available products formulated for inhalation, resulting in the off‐label use of other formulations, such as intravenous products, administered via nebulization. This review aims to examine the evidence supporting the efficacy of these off‐label formulations for management of acute and chronic infections associated with CF, as well as adverse effects associated with their use.
Nutrition in cystic fibrosis: From the past to the present and into the future
Authors: Altman Kimberly , McDonald Catherine M. , Michel Suzanne H. , Maguiness Karen 
Published: November 2019

AbstractNutritional management is an integral part of multidisciplinary care for persons with cystic fibrosis. This review will look at how nutrition care has evolved over time. In addition, we will look at how some newer therapies impact nutrition care.
Mucus, mucins, and cystic fibrosis
Authors: Morrison Cameron Bradley , Markovetz Matthew Raymond , Ehre Camille 
Published: November 2019

AbstractCystic fibrosis (CF) is both the most common and most lethal genetic disease in the Caucasian population. CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and is characterized by the accumulation of thick, adherent mucus plaques in multiple organs, of which the lungs, gastrointestinal tract and pancreatic ducts are the most commonly affected. A similar pathogenesis cascade is observed in all of these organs: loss of CFTR function leads to altered ion transport, consisting of decreased chloride and bicarbonate secretion via the CFTR channel and increased sodium absorption via epithelial sodium channel upregulation. Mucosa exposed to changes in ionic concentrations sustain severe pathophysiological consequences. Altered mucus biophysical properties and weakened innate defense mechanisms ensue, furthering the progression of the disease. Mucins, the high‐molecular‐weight glycoproteins responsible for the viscoelastic properties of the mucus, play a key role in the disease but the actual mechanism of mucus accumulation is still undetermined. Multiple hypotheses regarding the impact of CFTR malfunction on mucus have been proposed and are reviewed here. (a) Dehydration increases mucin monomer entanglement, (b) defective Ca2+ chelation compromises mucin expansion, (c) ionic changes alter mucin interactions, and (d) reactive oxygen species increase mucin crosslinking. Although one biochemical change may dominate, it is likely that all of these mechanisms play some role in the progression of CF disease. This article discusses recent findings on the initial cause(s) of aberrant mucus properties in CF and examines therapeutic approaches aimed at correcting mucus properties.
Pest control with drip‐applied dimethyl disulfide and chloropicrin in plastic‐mulched tomato (Solanum lycopersicum L.)
Authors: Yu Jialin , Sharpe Shaun M , Vallad Gary E , Boyd Nathan S 
Published: November 2019

AbstractBACKGROUNDDimethyl disulfide (DMDS) is used as a preplant soil fumigant for weed and soilborne pathogen control in plasticulture vegetable crops. The objective of this research was to determine the control efficacy of emulsifiable concentrate (EC) formulation of DMDS or DMDS + chloropicrin (Pic) on weed and Fusarium wilt in tomato (Solanum lycopersicum L.) plasticulture.RESULTSThe effective DMDS rates required to provide 50% (ER50) control of purple nutsedge (Cyperus rotundus L.) were 210 and 340 kg ha−1 at 4 weeks after fumigation (WAF) in fall 2017 and fall 2018, respectively, while these values increased to 348 and >467 kg ha−1, respectively, at 12 WAF. The ER50 values of DMDS + Pic were 150 and 240 kg ha−1 at 4 WAF in fall 2017 and fall 2018, respectively, while these values increased to 255 and 450 kg ha−1, respectively, at 12 WAF. DMDS + Pic was generally more effective than DMDS for C. rotundus control. The high rates of DMDS or DMDS + Pic provided adequate C. rotundus control in early season but failed to provide effective control by season end. In addition, DMDS + Pic injections through drip tape effectively reduced Fusarium oxysporum f. sp. lycopersici (FOL) inoculum while DMDS alone was generally ineffective.CONCLUSIONInjection of the EC formulation of DMDS or DMDS + Pic through drip tape should have been provided a viable option for C. rotundus and Fusarium wilt control in plastic‐mulched tomato. However, supplemental weed management actions, such as herbicide applications, may be required to achieve season‐long control. © 2019 Society of Chemical Industry
Deorphanization of an odorant receptor revealed new bioactive components for green mirid bug Apolygus lucorum (Hemiptera: Miridae)
Authors: Khashaveh Adel , An Xingkui , Shan Shuang , Xiao Yong , Wang Qi , Wang Shanning , Li Zibo , Geng Ting , Gu Shaohua , Zhang Yongjun 
Published: November 2019

AbstractBACKGROUNDThe Apolygus lucorum is one of the most destructive insect pests in China with a wide range of host plants. Interaction of A. lucorum with surrounding environment heavily relies on chemical communication. Deorphanization of receptors involved in odors detection elevates our understanding of the olfactory system of this pest and may help to develop a chemical ecology‐based control strategy.RESULTSAlucOR80, an odorant receptor (OR) in A. lucorum was newly cloned. Gene expression analysis showed that this receptor was mainly expressed in the antennae and head of both sexes but with a male bias. The Xenopus oocytes heterologous expression system coupled with the two‐electrode voltage‐clamp (TEVC) recording revealed that AlucOR80 was tuned to 21 selected compounds. Furthermore, electroantennogram (EAG) tests confirmed that all 21 ligands of AlucOR80 were electrophysiologically active in antennae of both sexes. Behavioral trials in a three‐cage olfactometer indicated that 16 compounds were behaviorally active, amongst which, 12 components were attractants and four components were repellents for adults of both sexes. Butyl butyrate and Dimethyl disulfide (DMDS) were the strongest attractive and repellant compounds, respectively. Importantly, we found the repellency of 1, 8‐Cineole, S‐(−)‐cis‐Verbenol and (1S)–(1)‐beta‐Pinene against adults of A. lucorum.CONCLUSIONAlthough AlucOR80 is a general OR, may play important role in the olfactory perception of A. lucorum. Screening of AlucOR80 ligands by behavioral assay provided valuable insights by which olfactory‐based management approaches could be developed by utilizing the behaviorally active components as attractants or repellents. © 2019 Society of Chemical Industry
A novel caged Cookson‐type reagent toward a practical vitamin D derivatization method for mass spectrometric analyses
Authors: Seki Masahiko , Sato Makoto , Takiwaki Masaki , Takahashi Koji , Kikutani Yoshikuni , Satoh Mamoru , Nomura Fumio , Kuroda Yutaka , Fukuzawa Seketsu 
Published: November 2019

Rationale25‐Hydroxylated vitamin D is the best marker for vitamin D (VD). Due to its low ionization efficiency, a Cookson‐type reagent, 1,2,4‐triazoline‐3,5‐dione (TAD), is used to improve the detection/quantification of VD metabolites by liquid chromatography/tandem mass spectrometry (LC/MS/MS). However, the high reactivity of TAD makes its solution stability low and inconvenient for practical use. We here describe the development of a novel caged Cookson‐type reagent, and we assess its performances in the quantitative and differential detection of four VD metabolites in serum using LC/MS/MS.MethodsCaged 4‐(4′‐dimethylaminophenyl)‐1,2,4‐triazoline‐3,5‐dione (DAPTAD) analogues were prepared from 4‐(4′‐dimethylaminophenyl)‐1,2,4‐triazolidine‐3,5‐dione. Their stability and reactivity were examined. The optimized caged DAPTAD (14‐(4‐(dimethylamino)phenyl)‐9‐phenyl‐9,10‐dihydro‐9,10‐[1,2]epitriazoloanthracene‐13,15‐dione, DAP‐PA) was used for LC/MS/MS analyses of VD metabolites.ResultsThe solution stability of DAP‐PA in ethyl acetate dramatically improved compared with that of the non‐caged one. We measured the thermal retro‐Diels‐Alder reaction enabling the release of DAPTAD and found that the derivatization reaction was temperature‐dependent. We also determined the detection limit and the lower limit of quantifications for four VD metabolites with DAPTAD derivatization.ConclusionsDAP‐PA was stable enough for mid‐ to long‐term storage in solution. This advantage shall contribute to the detection and quantification of VD in clinical laboratories, and as such to the broader use of clinical mass spectrometry.
Navigation strategy for robotic soft endoscope intervention
Authors: Jiang Wei , Zhou Yuanyuan , Wang Chongyang , Peng Lihua , Yang Yunsheng , Liu Hao 
Published: November 2019

AbstractBackgroundCurrent soft endoscope intervention mainly depends on the skills of endoscopists, especially for the orientation of the endoscope within the human tortuous lumen. This dependence causes inefficient and time‐consuming surgery.MethodsA human‐robot cooperation navigation strategy is proposed to perform the intervention of soft endoscope. The navigation strategy firstly detects the cavity center by processing the image of endoscope, then an auto‐orienting strategy is presented to automatically adjust the endoscope pointing to the detected cavity center.ResultsHuman phantom experiments are carried out to validate the effectiveness and feasibility of the navigation strategy. The results show that the cavity center is accurately extracted with whether the cavity is occluded or not and the auto‐orienting strategy could well point the endoscope around the cavity center.ConclusionThe proposed human‐robot cooperation navigation strategy releases endoscopists from the time‐consuming operations and improves the safety and automation of intervention procedures.
Formation control of singular multiagent systems with switching topologies
Authors: Liu Xiaofan , Xie Yongfang , Li Fanbiao , Shi Peng , Gui Weihua , Li Wenbo 
Published: November 2019

SummaryThis paper is concerned with the time‐varying formation control problem for singular multiagent systems with switching topologies. First, in order to eliminate the pulse solution of singular systems and extend the formation function set, the distributed formation controller has been formulated based on the output information of the agents. Then, the explicit expression of formation position function is presented based on the impulse free and the equivalent transformation of singular multiagent systems. Next, the sufficient and necessary conditions of the feasibility of the formation function are provided. Moreover, the sufficient conditions of formation control of singular multiagent systems with switching topologies are presented and the algorithm is designed to solve the distributed controller. Finally, the validity of the proposed approaches is verified by numerical simulation in this paper.
Assessing macroinvertebrate community response to restoration of Big Spring Run: Expanded analysis of before‐after‐control‐impact sampling designs
Authors: Smith Robert F. , Neideigh Emily C. , Rittle Alex M. , Wallace John R. 
Published: November 2019

AbstractStream restoration projects utilize a variety of approaches to improve conditions for aquatic organisms or enhance ecosystem function. Alterations to abiotic conditions to enhance certain ecosystems services may not lead to concurrent changes in the benthic macroinvertebrate community indicative of improved stream health. Big Spring Run was the location of a novel restoration project to recreate an anabranching “wet meadow” habitat typical of precolonization conditions without the primary goal of restoring a macroinvertebrate community characteristic of single‐channel lotic systems. We examined the effect of the restoration on the macroinvertebrate community using a multivariate analysis of assemblage composition, a before‐after‐control‐impact (BACI) approach, and an assessment of potential aerial migrants. We also examined subsets of the data using a BACI approach that represented restricted sampling designs often employed in stream restoration projects. Benthic macroinvertebrates were collected in the Spring twice prior to restoration (2010 and 2011) and 3 years after restoration (2012–2014). Adult stream insects were collected in 2014. Analyses of benthic macroinvertebrates and adult insects using the full dataset suggested that restoration had no effect on the macroinvertebrate community due to poor in‐stream conditions likely from sediment deposition following restoration. Dispersal barriers are likely acting as a secondary constraint on recolonization. Analyses using subsets of the data demonstrated that reference site quality and sampling extent can alter conclusions from a BACI approach. We found that a holistic approach using multiple lines of evidence required a nuanced approach to interpreting the data but was also informative for assessing project success. Robust monitoring protocols are likely the best approach for producing convincing results through a single line of evidence. The additional BACI analyses performed for this study, however, allowed the modest sampling regime employed to generate a broad narrative demonstrating that the macroinvertebrate assemblage did not respond to this type of restoration. Thus, we believe the holistic approach we employed can strengthen assessments of stream restoration projects when resources for monitoring are limited.
Translanguaging and Literacies
Authors: García Ofelia , Kleifgen Jo Anne 
Published: November 2019

AbstractThe authors trace the development of the concept of translanguaging, focusing on its relation to literacies. The authors describe its connection to literacy studies, with particular attention to bi/multilingual reading and writing. Then, the authors present the development of translanguaging as a sociolinguistic theory, discuss its formulations, and describe what is unique about translanguaging: its beginnings and grounding in educational practice and attention to the performances of multilinguals. The authors argue that multilingualism and bi/multiliteracies cannot be fully understood as simply the use of separate conventionally named languages or separate modes. Instead, translanguaging in literacies focuses on the actions of multilingual readers and writers, which go beyond traditional understandings of language, literacy, and other concepts, such as bi/multilingualism and bi/multilingual literacy. The authors show how multilinguals do language and literacy and how they do so in school. The authors review case studies that demonstrate how a translanguaging literacies framework is used to deepen multilingual students’ understandings of texts, generate students’ more diverse texts, develop students’ sense ofconfianza(confidence) in performing literacies, and foster critical metalinguistic awareness. The authors end by discussing implications for literacy pedagogy, as well as literacy research, that centers multilingual students.
The effect of first high school science teacher's gender and gender matching on students' science identity in college
Authors: Chen Chen , Sonnert Gerhard , Sadler Philip M. 
Published: November 2019

AbstractTo encourage the formation of science identity among girls, many scholars and practitioners have suggested to assign same‐gender science teachers to students so that the teachers can serve as gender role models. However, direct evidence of any long‐term effect of gender‐matching is scarce. In a nationally representative survey of college students from the United States, we investigated if gender‐matching between students and their first high school science teachers was associated with students' stronger identity in those science subjects in college. In physics, we found no gender‐matching effect. In chemistry, there was a gender‐matching effect only for women students. In biology, there were gender‐matching effects for students of both genders. In addition, we found that students in general had a lower science identity if they reported a negative influence of opposite gender domination (IOGD) on their career choices. However, for female students who were at the negative end of the IOGD scale, female biology teachers raised the level of biology identity to the grand average. Our findings suggested that the gender role model effect was strongest when the gender role models resonated with the overall disciplinary gender representation at the school or societal levels.