bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of suction on prolonged air leak after VATS lobectomies: a prospective randomized study
Authors: Maslak O. S. , Pischik V. G. , Obornev A. D. , Zinchenko E. I. , Kovalenko A. I. 
Published: November 2020

Background. Prolonged air leak is the most common postoperative complication following lung resection. Despite the huge number of researches concerning this problem, no consensus exists regarding the choice of the appropriate method of pleural space drainage after thoracoscopic surgery.Objective. To compare suction and water-seal regarding their influence on the incidence of prolonged air leak.Material and Methods. This prospective randomized trial included sixty patients who underwent VATS lobectomies on different diagnoses in the Center for Thoracic Surgery, Clinical Hospital no. 122 (St. Petersburg) from September 2018 until May 2020. The open-label randomized controlled trial involved two groups: control group (water-seal drainage) and suction group. Each group consisted of thirty patients. Ten patients were discharged with a Heimlich valve.Results. The incidence of prolonged air leak was 23%. Patients in the suction group had a higher duration of air leak than those in the control group (5.3 ± 1.3 vs 3.7 ± 0.9 days, р = 0.04). The number of air leak cases was slightly higher in the suction group (8 and 6 patients); however, the difference was not significant (р = 0.57). Both groups had no difference in the number of complications (р = 0.2). There were no cases of reoperation.Discussion. The advantage of water-seal is a lower risk of parenchymal defects. Suction may increase holes in visceral pleura, cause hyperexudation, leading to prolonged duration of drainage. At the same time, the use of suction may decrease residual pleural spaces, match visceral and parietal pleura, which may decrease the duration of air leak. A lot of studies on this issue was performed, however, their results are contradictory.Conclusion. Drainage of pleural space after VATS lobectomies may be safely performed with water-seal. In the case of increasing surgical emphysema or appearance of progressive dyspnea, suction should be applied
Development of an algorithm for the clinical and instrumental diagnosis of non-compression lumbar pain syndromes to optimize the use of puncture surgical techniques
Authors: Kalinin A. A. , Okoneshnikova A. K. , Pestryakov Yu. Ya. , Shepelev V. V. , Byvaltsev V. A. 
Published: November 2020

Background. Pain syndromes developing as a result of degeneration of the lumbar segments of the spine constitute a significant problem in modern vertebrology. The results of the application of preoperative diagnostic provocative tests are contradictory, and therefore the mixed effectiveness of puncture surgical techniques is recorded.Objective. To develop an algorithm for the clinical and instrumental diagnosis of non-compression lumbar pain syndromes to optimize the use of puncture surgical techniques.Material and Methods. The study included 923 patients who underwent provocative diagnostic techniques on the intervertebral disk (IVD) and the arched joints (AJ) between 2012 and 2017. Taking into account clinical and instrumental data, the following are made: in group I (n=246) – laser IVD nucleoplasty, in group II (n = 287) – laser denervation of FJ, in group III (n = 390) – simultaneous use of laser exposure to IVD and AJ. We analyzed the dynamics of the level of pain in the lumbar spine and lower extremities according to The Visual Analogue Scale and quality of life according to The Short Form-36 (SF-36) questionnaire.Results. When performing provocative diagnostic tests, the minimum number of adverse effects was recorded: 3.2% in group I, 2.4% in group II, and 2.1% in group III. After puncture methods of surgical treatment, a significant persistent decrease in the severity of preoperative pain was observed both in the lumbar spine (p = 0.002, p = 0.005 and p = 0.004, respectively) and in the lower extremities (p = 0.003, p = 0.001 and p = 0.005, respectively) A significant improvement in the physical and psychological components of health was also established in group I (p = 0.02 and p = 0.01, respectively), in group II (p = 0.01 and p = 0.03, respectively) and group III (p = 0.03 and p = 0.02, respectively).Conclusion. In the presence of neuroimaging parameters of IVD according to C. Pfirrmann III–IV and protrusion size 4–6 mm, minimal degenerative changes in the AJ according to A. Fujiwara I–II and D. Weishaupt I–II, as well as a positive disruption test, it is possible to perform laser nucleoplasty. In case of detection of neuroimaging data of IVD according to C. Pfirrmann I–II and protrusion size less than 4 mm, moderately pronounced degenerative changes in the AJ according to A. Fujiwara II–III and D. Weishaupt II–III, as well as positive paraarticular stimulation of AJ, laser denervation of AJ is recommended. When determining, according to neuroimaging data, moderate degenerative changes in IVD according to C. Pfirrmann over III and protrusion size 4–6 mm, as well as degeneration of AJ according to A. Fujiwara more than II and D. Weishaupt more than II, positive of samples and paraarticular stimulation of AJ, it is advisable to perform simultaneous surgical intervention in the volume of laser IVD nucleoplasty and laser denervation of AJ.
Bone marrow edema in terms of joint pathology
Authors: Airapetov G. A. , Vorotnikov A. A. , Vasyukov V. A. 
Published: November 2020

New possibilities of modern medical science open up prospects for instrumental and laboratory diagnostics of many pathological conditions, unknown or not previously diagnosed in the practice of an orthopedist. These include bone marrow edema. Not only orthopedic traumatologists, but also rheumatologists, neurosurgeons, general practitioners, rehabilitation therapists, morphologists, and many others today face this concept in a variety of definitions, concepts of etiology, pathogenesis, and clinical recommendations for treatment.The authors performed a systematic review by using four open resources: electronic scientific library (elibrary), PubMed, SciVerse (Science Direct), and Scopus.The complexity of pathology lies in the fact that in each specific case, the development of treatment tactics requires a personal interpretation of the entire variety of data obtained and a case by case approach.
Reframing: cataloguing patterned azulejos frames
Authors: Da Silva Aguiar Inês 
Published: November 2020

The present paper aims to analyze the cataloguing of azulejo frames, done for the project Cataloguing Portuguese azulejo patterns initiated in 2011, which can be consulted at Az Infinitum – Sistema de Referência e Indexação de Azulejo (Azulejo Indexation and Referencing System)
(http://redeazulejo.letras.ulisboa.pt/pesquisa-az).
The importance of the azulejo frame and its independent study, and its connections with the study of the patterns that constitute the remain of the wall and ceiling coverings, has been a crucial concept since the beginning of the project, as it contributes to a better understanding of how pattern azulejo frames were understood throughout the centuries.
Also, the systematic cataloguing allows the addition and continuous processing of new data in Az Infinitum, stimulating the emergence of new questions and thus contributing to the production of theoretical knowledge, without never losing sight of its object of study: the work of art in situ.
The Graffiti covering of the National Technical University of Athens and its polico-cultural symbolism
Authors: Drakopoulou Konstantina 
Published: November 2020

Artistic activity which violates urban space is based on the aesthetics of vandalism; it underscores the emergence of the artist as a guerrilla fighter and a defacer, reminiscent of art practices developed during the historical and the post-war avant-garde. The intervention of three graffiti artists, who completely covered the southern annex facades of the National Technical University of Athens’ neoclassical building with large-scale black and white abstract patterns in March 2015, can be understood within the framework of trauma theory and destruction art, as explained by the art historian Kristine Stiles.
The writers’ choice to intervene in the Athens Polytechnic in the Exarcheia district — both traditional enclaves of political protest — as well as the morphology of the pieces themselves arising from bottom up mutual interactions with no underpinning organising principle, need to be interpreted on the basis of the political model of emergent democracy. The objective of this correlation is to exemplify how the graffiti writers’ self-organizing behaviour during the production of the works can be viewed within the workings of political movements. This brand of politics, the self-organizing of local communities and collectives, may prove to be extremely apt in recognizing and improving troubled domains of community life, especially today when Greeks are facing a traumatic crisis.
Companhias de Azulejadores e de Pintores de Azulejos activas em Lisboa entre 1757 e 1773: novos contributos para o estudo da produção de azulejos no Período Pombalino
Authors: Mesquita Mendes Rui Manuel 
Published: November 2020

A segunda metade do século XVIII é uma época em que a actividade dos azulejadores e pintores de azulejos em Lisboa está ainda pouco documentada e, por isso, também ainda insuficientemente estudada.
Nesse período da chamada reconstrução pombalina, posterior ao terramoto de 1755, assistimos ao progres­sivo esforço de reconstrução e reorganização do tecido económico e social da cidade. Para enfrentar os novos desafios com que então eram confrontados, os mestres ladrilhadores organizaram-se em sociedades com o objectivo de garantir o capital necessário para a realização das obras do seu oficio, enquanto os pinto­res de azulejo criaram uma sociedade para assegurar uma remuneração justa para o trabalho de pintura.
A documentação notarial dessas sociedades, agora revelada, permite não só compreender o seu modo de trabalho, como identificar melhor alguns dos principais mestres azulejadores e pintores de azulejos activos em Lisboa no terceiro quartel do século XVIII.
Delfim Maya e a liberdade de ser e de criar
Authors: Maya Maria José 
Published: November 2020

Delfim Maya (1886-1978) iniciou a sua carreira artística em 1931, com 45 anos, depois de ter estado preso por razões políticas. Lutou pelas suas convicções monárquicas, o que o levou a ser preso e demitido do Exército em 1919. Fugiu da prisão e exilou-se em Espanha, onde viveu até 1921, o que teve grande influência na sua arte. Ainda que com enormes constrangimentos financeiros, a sua independência do poder político deu-lhe liberdade para criar uma arte diferente e ter um percurso único na arte portuguesa.
O desejo de liberdade revela-se também no movimento que imprime às suas esculturas, característica marcante da obra deste artista.
Delfim Maya foi o primeiro escultor português a construir esculturas em chapa industrial de metal. O processo como o fez também foi original: desenhava uma planificação e erguia a escultura a partir dela numa única chapa, sem soldaduras. Podemos enquadrá-lo num movimento neo-cubista.
Expressões de Poder: o Palácio de Cristal Portuense na primeira Exposição Colonial Portuguesa (1934)
Authors: Da Silva Braga Penetra Gonçalves Vera Lúcia 
Published: November 2020

O Palácio de Cristal Portuense serviu, desde a sua inauguração em 1865, como palco para alguns dos mais importantes eventos nacionais. Entre estes merece destaque a Primeira Exposição Colonial Portuguesa, enqua­drada na ideologia do Estado Novo e realizada no Porto em 1934. O presente artigo procura, assim, traçar as principais linhas desta mostra, sobretudo naquilo que respeita à análise do recinto e das transformações aí implementadas através de soluções arquitetónicas efémeras. A atualização da fachada oitocentista do Palácio, para além de responder ao próprio gosto da época, pode também revelar-se como uma primeira necessidade e intenção de adaptação do edifício.
A análise aqui apresentada parte de uma revisão bibliográfica e de um cruzamento entre fontes hemerográficas e iconográficas, como forma de contribuir para o estudo da história do Palácio de Cristal, escolhido como montra para a demonstração política e ideológica do regime em 1934.
On the Lagrange Stability of the Motion in the Spatial Elliptic Restricted Three-body Problem
Authors: Sosnitskii Stepan P. 
Published: November 2020

Abstract
We study the Lagrange stability in the spatial elliptic restricted three-body problem. In this study, we essentially use the boundedness of the motion of a small particle with respect to planar coordinates and show that this plays a key role in ensuring the boundedness of the motion in the spatial case. As a result, we obtain the Lagrange stability theorem for an infinitely small particle in the spatial elliptic restricted three-body problem. The proposed approach can then be extended to the case of the general three-body problem.
Renormalization Group Analysis of the Turbulent Hydromagnetic Dynamo: The Effect of Nonstationarity
Authors: Mizerski Krzysztof A. 
Published: November 2020

Abstract
The turbulent hydromagnetic dynamo is a process of magnetic field generation by chaotic flow of an electrically conducting fluid (plasma, liquid iron, etc.). It is responsible for generation of large-scale magnetic fields of astrophysical objects such as planets, stars, accretion disks, galaxies, galaxy clusters, etc. In particular, the dynamical process of induction of large-scale fields by highly conducting plasma has been very difficult to understand, as very low resistivity is not capable of creating a phase shift between magnetic and kinetic components of waves, making their interaction ineffective for generation of a large-scale electromotive force (EMF). The aim of the analysis presented here is to demonstrate that when the typically invoked statistical stationarity of turbulence is relaxed, large-scale magnetic fields can be very effectively generated by low-resistivity plasma. The renormalization group technique is applied to extract the final expression for the mean EMF from the fully nonlinear dynamical equations (Navier–Stokes, induction equation), and the mean field equations are solved for a force-free mode. Nonstationarity is shown to strongly enhance the process of large-scale EMF generation via wave interactions, and the dynamo effect induced by nonstationarity is proved to be effective. The results are also used to demonstrate the influence of magnetic fields and nonstationarity on energy and helicity spectra of turbulent flows.
The Stellar Merger Scenario for Black Holes in the Pair-instability Gap
Authors: Renzo M. , Cantiello M. , Metzger B. D. , Jiang 姜燕 Y.-F. 飞 
Published: November 2020

Abstract
The recent detection of GW190521 stimulated ideas on how to populate the predicted black hole (BH) pair-instability (PI) mass gap. One proposal is the dynamical merger of two stars below the PI regime forming a star with a small core and an oversized envelope. We outline the main challenges this scenario faces to form one BH in the gap. In particular, the core needs to avoid growing during the merger, and the merger product needs to retain enough mass, including in the subsequent evolution, and at core collapse (CC). We explore this scenario with detailed stellar evolution calculations, starting with ad hoc initial conditions enforcing no core growth during the merger. We find that these massive merger products are likely to be helium-rich and spend most of their remaining lifetime within regions of instabilities in the Herzsprung–Russell diagram, such as luminous blue variable eruptions. An energetic estimate of the amount of mass loss neglecting the back reaction of the star suggests that the total amount of mass that can be removed at low metallicity is ≲1 M
⊙. This is small enough that at CC our models are retaining sufficient mass to form BHs in the PI gap similar to the recent ones detected by LIGO/Virgo. However, mass loss at the time of merger, the resulting core structure, and the mass loss at CC still need to be quantified for these models to confirm the viability of this scenario.
Constraining Gravitational Wave Polarization with GW190521 and ZTF19abanrhr
Authors: Haster Carl-Johan 
Published: November 2020

Abstract
Gravitational waves (GWs) in general relativity are assumed to contain only tensorial polarization states, with generic metric theories of gravity also allowing for vector- and scalar-polarized GWs. Assuming an association between the gravitational-wave and electromagnetic transients GW190521 and ZTF19abanrhr, we find a preference for tensorial GWs with a log10 Bayes factor of 21.6 (with respect to vector-polarized GWs) and 38.4 (with respect to scalar-polarized GWs).
New approach for tuberculosis contact tracing implemented in the two regions of Kyrgyz Republic during 2017-2018
Authors: Dzhangaziev Bakyt , Kulzhabaeva Aizat , Truzyan Nune , Zhoroev Abdykadyr , Otorbaeva Dinagul , Temirbekov Sanzharbek , Shahumyan Elina , Davtyan Karapet , Isakov Tolo 
Published: November 2020

Introduction: Tuberculosis (TB) contact investigation as a proved approach for finding new TB cases, is not fully performed in Kyrgyzstan. In 2018, the country started aligning the National Guidelines for tracking contacts with the WHO recommendations by expanding the definition for TB index cases to all close contacts, regardless of their TB risk status.
Methodology: This cross-sectional census aimed to determine the active case detection changes among TB contacts after implementation of a new TB tracing strategy using the National Surveillance data. We compared populations in Chui and Issyk-Kul regions of Kyrgyzstan who had contacts with TB index cases before (2017) and after (2018) strategic changes for the rates of indexes, contacts, screened contacts, and detected TB among screened contacts.
Results: New TB tracing strategy resulted in increased numbers of indexes (21%) and contacts (36%). Though the smaller number of contacts (1730 vs. 1590) have been screened in 2018, the proportion of TB diagnosed was substantially higher (95% CI: 0.024-0.005; p = 0.002) in 2018 vs. 2017. The mean numbers of TB contacts per-one-index-case also has increased dramatically by 117% (1.8 vs. 3.9) in Chui and by 43% (3.0 vs. 4.3) in Issyk-Kul regions (95% CI: 3.20-3.37; p < 0.001 and 95% CI: 2.97-3.09; p < 0.001, respectively) between 2018 and 2017.
Conclusion: Extending new tracing approach to other regions of Kyrgyzstan will increase the number of identified contacts, leading to better TB control in the country and prevention of more severe TB development among the unidentified contacts.
Foxo1 Serine 209 Is a Critical Regulatory Site of CD8 T Cell Differentiation and Survival
Authors: Hills Leonard Benjamin , Abdullah Leena , Lust Hannah E , Degefu Hanna , Huang Yina H 
Published: November 2020

Abstract
Foxo1 is an essential transcription factor required for the survival and differentiation of memory CD8 T cells, yet it is unclear whether these Foxo1-dependent functions are inherently coupled. To address this question, we examined the effects of different Foxo1 posttranslational modifications. Phosphorylation of Foxo1 by Akt kinases at three distinct residues is well characterized to inhibit Foxo1 transcriptional activity. However, the effect of Foxo1 phosphorylation within its DNA-binding domain at serine 209 by Mst1 kinase is not fully understood. In this study, we show that an S209A phospho-null Foxo1 exhibited Akt-dependent nuclear trafficking in mouse CD8 T cells and augmented the expression of canonical Foxo1 target genes such as Il7r and Sell. In contrast, an S209D phosphomimetic Foxo1 (SD-Foxo1) was largely excluded from the nucleus of CD8 T cells and failed to transactivate these genes. RNA sequencing analysis revealed that SD-Foxo1 was associated with a distinct Foxo1-dependent transcriptional profile, including genes mediating CD8 effector function and cell survival. Despite defective transactivation of canonical target genes, SD-Foxo1 promoted IL-15–mediated CD8 T cell survival in vitro and survival of short-lived effector cells in vivo in response to Listeria monocytogenes infection. However, SD-Foxo1 actively repressed CD127 expression and failed to generate memory precursors and long-lived memory T cells. Together, these data indicate that S209 is a critical residue for the regulation of Foxo1 subcellular localization and for balancing CD8 T cell differentiation and survival.
Multibatch Cytometry Data Integration for Optimal Immunophenotyping
Authors: Ogishi Masato , Yang Rui , Gruber Conor , Zhang Peng , Pelham Simon J , Spaan András N , Rosain Jérémie , Chbihi Marwa , Han Ji Eun , Rao V Koneti , Kainulainen Leena , Bustamante Jacinta , Boisson Bertrand , Bogunovic Dusan , Boisson-Dupuis Stéphanie , Casanova Jean-Laurent 
Published: November 2020

Abstract
High-dimensional cytometry is a powerful technique for deciphering the immunopathological factors common to multiple individuals. However, rational comparisons of multiple batches of experiments performed on different occasions or at different sites are challenging because of batch effects. In this study, we describe the integration of multibatch cytometry datasets (iMUBAC), a flexible, scalable, and robust computational framework for unsupervised cell-type identification across multiple batches of high-dimensional cytometry datasets, even without technical replicates. After overlaying cells from multiple healthy controls across batches, iMUBAC learns batch-specific cell-type classification boundaries and identifies aberrant immunophenotypes in patient samples from multiple batches in a unified manner. We illustrate unbiased and streamlined immunophenotyping using both public and in-house mass cytometry and spectral flow cytometry datasets. The method is available as the R package iMUBAC (https://github.com/casanova-lab/iMUBAC).
The Invariant NKT Cell Response Has Differential Signaling Requirements during Antigen-Dependent and Antigen-Independent Activation
Authors: Anderson Courtney K , Reilly Shanelle P , Brossay Laurent 
Published: November 2020

Abstract
Invariant NKT (iNKT) cells are an innate-like population characterized by their recognition of glycolipid Ags and rapid cytokine production upon activation. Unlike conventional T cells, which require TCR ligation, iNKT cells can also be stimulated independently of their TCR. This feature allows iNKT cells to respond even in the absence of glycolipid Ags, for example, during viral infections. Although the TCR-dependent and -independent activation of iNKT cells have been relatively well established, the exact contributions of IL-12, IL-18, and TLRs remain unclear for these two activation pathways. To definitively investigate how these components affect the direct and indirect stimulation of iNKT cells, we used mice deficient for either MyD88 or the IL-12Rβ2 in the T cell lineage. Using these tools, we demonstrate that IL-12, IL-18, and TLRs are completely dispensable for the TCR activation pathway when a strong agonist is used. In contrast, during murine CMV infection, when the TCR is not engaged, IL-12 signaling is essential, and TLR signaling is expendable. Importantly, to our knowledge, we discovered an intrinsic requirement for IL-18 signaling by splenic iNKT cells but not liver iNKT cells, suggesting that there might be diversity, even within the NKT1 population.
A proof of the linear Arithmetic Fundamental Lemma for
Authors: Li Qirui 
Published: November 2020

AbstractLet
$K/F$
be an unramified quadratic extension of a non-Archimedean local field. In a previous work [1], we proved a formula for the intersection number on Lubin–Tate spaces. The main result of this article is an algorithm for computation of this formula in certain special cases. As an application, we prove the linear Arithmetic Fundamental Lemma for
$ \operatorname {{\mathrm {GL}}}_4$
with the unit element in the spherical Hecke Algebra.