bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health information professionals: delivering core services and value in extraordinary times
Authors: Johnson Frances 
Published: June 2020

AbstractThe 2020 virtual issue of the Health Information and Libraries Journal (HILJ) is published to link to the CILIP Health Libraries Group Conference which was to take place in Scotland 22–25th July. Whilst the conference was postponed in light of the coronavirus (COVID‐19) pandemic, its themes of (i) Working in Partnership; (ii) Resilience and Well‐being; (iii) Public and Patient involvement; (iv) Quality Impact and Metrics; and (v) Improvement and Innovation have nevertheless provided the basis on which to compile this virtual issue. Overarching these themes is a core value of the HIL profession, to provide relevant, timely and sustainable information services, and the articles selected from HILJ (2018 through to March 2020) contribute to the aim of meeting and going beyond these goals under the conference banner of ‘not your average day in the office’. The virtual issue mirrors the format of a regular issue of HILJ, a review article, four original articles and three from our regular features: ‘Dissertations into Practice’, ‘International Perspectives and Initiatives’ and ‘Teaching and Learning in Action’. The authors come from Canada, China, Croatia, Sweden and the UK. All articles included in this issue are available online.
Evaluation of the use of lactic acid bacteria and Thymus vulgaris essential oil on Suffolk and Ile de France lamb breed (MuscuIus gluteus) quality parameters
Authors: Klupsaite Dovile , Zavistanaviciute Paulina , Sakiene Vytaute , Lele Vita , Mozuriene Erika , Klementaviciute Jolita , Sidlauskiene Sonata , Buckiuniene Vilija , Tolpeznikaite Ernesta , Ruibys Romas , Bartkiene Elena 
Published: June 2020

SummaryIn the present study, Lactobacillus plantarum (LUHS135), Thymus vulgaris essential oil (0.1% v/v) and their combination were used to treat Suffolk and Ile de France lamb meat. Changes in the microbiological profile and physicochemical parameters of meat were evaluated after 24 h of treatment at 4 °C. Treatments resulted in significantly lower mould/yeast, total enterobacteria (by up to 45%) counts, water‐holding capacity (by 21–63%) and cooking loss (by 17–35%) in all samples. Moisture content increased, on average, by 14.5% in the Suffolk meat. Polyunsaturated fatty acid content increased after all treatments. Treatments and breed significantly affected the content of malondialdehyde and some biogenic amines. Sensory analysis showed that raw lamb meat colour was more acceptable after all treatments, while the odour acceptability was ranked highest after combined treatment. These findings suggest that the applied treatments could be used to improve microbiological safety and some quality characteristics and to increase the PUFA content of lamb meat.
Improving mental health of student and novice nurses to prevent dropout: A systematic review
Authors: Bakker Ellen J. M. , Kox Jos H. A. M. , Boot Cécile R. L. , Francke Anneke L. , van der Beek Allard J. , Roelofs Pepijn D. D. M. 
Published: June 2020

AbstractAimsTo provide: (a) an overview of interventions aimed at improving mental health of student or novice nurses; and (b) an evaluation of their effectiveness on dropout‐related outcomes.DesignSystematic review.Data sourcesResearch papers published between January 1971–February 2019 were identified from the following databases: Embase, Medline, PsycInfo, CINAHL, ERIC, the Cochrane Library, Web of Science, and Google Scholar.Review methodsWe followed the procedures recommended by the Editorial Board of the Cochrane Collaboration Back Review Group. We included peer‐reviewed articles with a quantitative research design, examining interventions aimed at improving mental health of student and novice nurses and their effect on dropout‐related outcomes. The large variation in studies prohibited statistical pooling and a synthesis without meta‐analysis of studies was performed.ResultsWe identified 21 studies with three areas of focus: managing stress or stressors (N = 4); facilitating the transition to nursing practice (N = 14); and a combined approach (N = 3). Five studies showed a statistically significant effect on dropout‐related outcomes. The overall risk of bias was high.ConclusionA wide range of interventions are available, but the evidence for their effectiveness is limited. There is a need for high‐quality studies in this field, preferably with a randomized controlled design.
Asymmetric information consolidation and price discovery: Inferring bad news from insider sales
Authors: Karamanou Irene , Pownall Grace , Prakash Rachna 
Published: June 2020

AbstractDue to the paucity of sources of negative firm‐specific information, US capital markets have more difficulty identifying and incorporating bad news into stock prices than they do good news. Even though insider selling is a potentially important proxy for undisclosed bad news, researchers have difficulty ex ante identifying information‐based sales due to an inability to separate liquidity‐motivated from information‐based insider trades. We hypothesize that when insiders in multiple firms sell shares of one firm in which they are insiders and at the same time buy shares of other insider portfolio firms, the sale is more likely to be information‐based, since the proceeds are reinvested. Conversely, when an insider sells one firm without purchasing others or sells multiple insider firms the sale is likely liquidity‐motivated. We find that insider sales identified as information‐based using this algorithm are followed by significant negative abnormal returns. Information‐based sales are also more likely to be associated with delistings, earnings declines and earnings restatements. Analysts are also more likely to revise their earnings forecasts downwards for these firms. It is thus possible to ex ante identify insider sales with information content. Our results will be of interest to investors and also to regulators designing insider trading rules.
The association between allergic rhinitis and risk of rheumatoid arthritis: A systematic review and meta‐analysis
Authors: Charoenngam Nipith , Ponvilawan Ben , Rittiphairoj Thanitsara , Tornsatitkul Surapa , Wattanachayakul Phuuwadith , Rujirachun Pongprueth , Ungprasert Patompong 
Published: June 2020

AbstractObjectiveTo investigate the association between allergic rhinitis (AR) and the risk of rheumatoid arthritis (RA).MethodsPotentially eligible studies were identified from MEDLINE and EMBASE databases from inception to November 2019. Eligible cohort study must report relative risk with 95% confidence intervals (95% CIs) of incident RA between AR patients and comparators. Eligible case‐control studies must include cases with RA and controls without RA, and must explore their history of AR. Odds ratio with 95% CIs of the association between AR and RA must be reported. Point estimates with standard errors from each study were combined using the generic inverse variance method.ResultsA total of 21,824 articles were identified. After two rounds of the independent review by three investigators, two cohort studies and 10 case–control studies met the eligibility criteria. The pooled analysis showed no association between AR and risk of RA (RR = 0.94; 95% CI, 0.73 to 1.20; I2 = 84%). However, when we conducted a sensitivity analysis including only studies with acceptable quality, defined as Newcastle‐Ottawa score of seven or higher, we found that patients with AR had a significantly higher risk of RA (RR = 1.36; 95% CI, 1.12 to 1.65; I2 = 45%).ConclusionsThe current systematic review and meta‐analysis could not reveal a significant association between AR and RA. However, when only studies with acceptable quality were included, a significantly higher risk of RA among patients with AR than individuals without AR was observed.
Deficiency of mitochondrial outer membrane protein 64 confers rice resistance to both piercing‐sucking and chewing insects in rice
Authors: Guo Hui‐Min , Li Hai‐Chao , Zhou Shi‐Rong , Xue Hong‐Wei , Miao Xue‐Xia 
Published: June 2020

AbstractThe brown planthopper (BPH) and striped stem borer (SSB) are the most devastating insect pests in rice (Oryza sativa) producing areas. Screening for endogenous resistant genes is the most practical strategy for rice insect‐resistance breeding. Forty‐five mutants showing high resistance against BPH were identified in a rice T‐DNA insertion population (11,000 putative homozygous lines) after 4 years of large‐scale field BPH‐resistance phenotype screening. Detailed analysis showed that deficiency of rice mitochondrial outer membrane protein 64 (OM64) gene resulted in increased resistance to BPH. Mitochondrial outer membrane protein 64 protein is located in the outer mitochondrial membrane by subcellular localization and its deficiency constitutively activated hydrogen peroxide (H2O2) signaling, which stimulated antibiosis and tolerance to BPH. The om64 mutant also showed enhanced resistance to SSB, a chewing insect, which was due to promotion of Jasmonic acid biosynthesis and related responses. Importantly, om64 plants presented no significant changes in rice yield‐related characters. This study confirmed OM64 as a negative regulator of rice herbivore resistance through regulating H2O2 production. Mitochondrial outer membrane protein 64 is a potentially efficient candidate to improve BPH and SSB resistance through gene deletion. Why the om64 mutant was resistant to both piercing‐sucking and chewing insects via a gene deficiency in mitochondria is discussed.
LncRNA Fendrr inhibits hypoxia/reoxygenation-induced cardiomyocyte apoptosis by downregulating p53 expression
Authors: Li Xiang , Ni Liangchun , Wang Weixin , Zong Liang , Yao Bi 
Published: June 2020

Abstract

Objective
LncRNA Fendrr plays an important role in cardiac development, but its role in myocardial ischaemia–reperfusion (I/R) injury remains unclear. P53 has been shown to be an important regulator of apoptosis and is involved in myocardial I/R-induced apoptosis. This study aims at investigating whether Fendrr affects hypoxia/reoxygenation (H/R)-induced cardiomyocyte apoptosis through p53.

Methods
The left anterior descending coronary artery of the rat was ligated for 30 min and then reperfusion for 120 min by releasing the suture. Neonatal rat ventricular myocytes (NRVM) and rat cardiac cell line H9c2 were cultured for 6 h in hypoxia (95% N2 and 5% CO2), followed by reoxygenation (95% air and 5% CO2) for 6 h. Transfection were performed in cells. Apoptosis was detected by flow cytometry. Moreover, RNA pull-down, RNA immunoprecipitation, ubiquitination assay, GST pull-down assay and co-immunoprecipitation were used to detect the regulation of Fendrr on p53 protein.

Key findings
Fendrr was decreased in I/R-induced myocardium and H/R-induced cardiomyocyte, and overexpression of Fendrr inhibited H/R-induced NRVM or H9c2 cells apoptosis. Further research found that the 1381–2100 nt of Fendrr bound to p53 protein and Fendrr promoted t direct binding of p53 to Cop1. The inhibition of Fendrr reduced the binding of E3 ubiquitin–protein ligase constitutive photomorphogenesis protein 1 (COP1) to p53 and reduced the ubiquitination of p53. Furthermore, the inhibition of Fendrr on H/R-induced NRVM or H9c2 cells apoptosis could be reversed by overexpression of p53.

Conclusions
Fendrr can inhibit H/R-induced cardiomyocyte apoptosis, which is partly through promoting the ubiquitination and degradation of p53 by increasing the binding of Cop1 and p53.
Sacral nerve stimulation ameliorates colonic barrier functions in a rodent model of colitis
Authors: Tu Lei , Gharibani Payam , Yin Jieyun , Chen Jiande D. Z. 
Published: June 2020

AbstractBackgroundThe mucosal barrier damage is recognized as one of the key factors in the pathogenesis of colitis. While sacral nerve stimulation (SNS) was reported to have therapeutic potential for colitis, its mechanisms of actions on colonic permeability remained largely unknown.MethodsIn this study, colitis was induced by intrarectal administration of TNBS in rats. Five days later, they were treated with SNS or sham‐SNS for 10 days. The effects of SNS on colonic permeability were assessed by measuring the expression of tight‐junction proteins involved in regulating permeability and the FITC‐dextran test. The mechanism of actions of SNS was investigated by studying the function of the enteric nervous system (ENS) cells and analyzing the autonomic nervous system.Key ResultsSNS decreased the disease activity index, microscopic and macroscopic scores, myeloperoxidase activity, and pro‐inflammatory cytokines (TNF‐α, IL‐6). SNS increased the expression of Zonula Occludens‐1, Occludin, Claudin‐1, and Junctional adhesion molecule‐A in the colon tissue. The FITC‐dextran test showed that the colonic permeability was lower with SCS than sham‐SNS. SNS increased ChAT, pancreatic polypeptide, and GDNF and reduced norepinephrine NGF, sub‐P, and mast cell overactivation in the colon tissue. Concurrently, SNS increased acetylcholine in colon tissues and elevated vagal efferent activity.Conclusions & InferencesSNS ameliorates colonic inflammation and enhances colonic barrier function with the proposed mechanisms involving the increase in parasympathetic activity and modulation of the activity of the ENS and immune system, including mast cells.
Bulbous perennials precisely detect the length of winter and adjust flowering dates
Authors: Jánosi Imre M. , Silhavy Dániel , Tamás Júlia , Csontos Péter 
Published: June 2020

Summary

In order to identify the most relevant environmental parameters that regulate flowering time of bulbous perennials, first flowering dates of 329 taxa over 33 yr are correlated with monthly and daily mean values of 16 environmental parameters (such as insolation, precipitation, temperature, soil water content, etc.) spanning at least 1 yr back from flowering.

A machine learning algorithm is deployed to identify the best explanatory parameters because the problem is strongly prone to overfitting for traditional methods: if the number of parameters is the same or greater than the number of observations, then a linear model can perfectly fit the dependent variable (observations).

Surprisingly, the best proxy of flowering date fluctuations is the daily snow depth anomaly, which cannot be a signal itself, however it should be related to some integrated temperature signal. Moreover, daily snow depth anomaly as proxy performs much better than mean soil temperature preceding the flowering, the best monthly explanatory parameter.

Our findings support the existence of complicated temperature sensing mechanisms operating on different timescales, which is a prerequisite to precisely observe the length and severity of the winter season and translate for example, ‘lack of snow’ information to meaningful internal signals related to phenophases.
Visual and hydraulic techniques produce similar estimates of cavitation resistance in woody species
Authors: Gauthey Alice , Peters Jennifer M. R. , Carins‐Murphy Madeline R. , Rodriguez‐Dominguez Celia M. , Li Ximeng , Delzon Sylvain , King Andrew , López Rosana , Medlyn Belinda E. , Tissue David T. , Brodribb Tim J. , Choat Brendan 
Published: June 2020

Summary

Hydraulic failure of the plant vascular system is a principal cause of forest die‐off under drought. Accurate quantification of this process is essential to our understanding of the physiological mechanisms underpinning plant mortality. Imaging techniques increasingly are applied to estimate xylem cavitation resistance. These techniques allow for in situ measurement of embolism formation in real time, although the benefits and trade‐offs associated with different techniques have not been evaluated in detail.

Here we compare two imaging methods, microcomputed tomography (microCT) and optical vulnerability (OV), to standard hydraulic methods for measurement of cavitation resistance in seven woody species representing a diversity of major phylogenetic and xylem anatomical groups.

Across the seven species, there was strong agreement between cavitation resistance values (P50) estimated from visualization techniques (microCT and OV) and between visual techniques and hydraulic techniques.

The results indicate that visual techniques provide accurate estimates of cavitation resistance and the degree to which xylem hydraulic function is impacted by embolism. Results are discussed in the context of trade‐offs associated with each technique and possible causes of discrepancy between estimates of cavitation resistance provided by visual and hydraulic techniques.
Clostridium butyricum: a promising probiotic confers positive health benefits in aquatic animals
Authors: Tran Ngoc Tuan , Li Zhongzhen , Ma Hongyu , Zhang Yueling , Zheng Huaiping , Gong Yi , Li Shengkang 
Published: June 2020

AbstractClostridium butyricum is a bacterium of rod shape, strictly anaerobic, Gram‐positive and form spores. Short‐chain fatty acids, biofuel compounds and precursors of biomaterials (H2, butanol and 1,3‐propanediol) are produced by C. butyricum during the fermentation of carbohydrates and sugars. In humans and animals, although C. butyricum has been found to be associated with botulism in infant and necrotising enterocolitis in preterm neonates, some strains have been demonstrated to be beneficial as probiotics. In aquatic animals, the application of C. butyricum as a probiotic has been commonly considered. In this review, we described and documented what we knew about the isolation, identification, phenotypic and biochemical characteristics, safety, pathogenicity and the mechanisms of action of C. butyricum in the gastrointestinal tract of aquatic animals. The evidence on the roles that C. butyricum plays in improving growth performance, digestibility, survival rate, immune response, disease resistance and the structure of intestinal tract, as well as the modulation of gut commensal microbiota and metabolic disorders in aquatic animals, is summarised. Albeit the probiotic C. butyricum has been applied in aquaculture, and further research, such as the inter‐relationships between the probiotic and the immune system of the host and the possible application of C. butyricum as an alternative to antibiotic substitution for the prevention and treatment of diseases, is required for future detailed studies.
Optimal Alpha Spending for Sequential Analysis with Binomial Data
Authors: Silva Ivair R. , Kulldorff Martin , Katherine Yih W. 
Published: June 2020

SummaryFor sequential analysis hypothesis testing, various alpha spending functions have been proposed. Given a prespecified overall alpha level and power, we derive the optimal alpha spending function that minimizes the expected time to signal for continuous as well as group sequential analysis. If there is also a restriction on the maximum sample size or on the expected sample size, we do the same. Alternatively, for fixed overall alpha, power and expected time to signal, we derive the optimal alpha spending function that minimizes the expected sample size. The method constructs alpha spending functions that are uniformly better than any other method, such as the classical Wald, Pocock or O’Brien–Fleming methods. The results are based on exact calculations using linear programming. All numerical examples were run by using the R Sequential package.
Dynamic Nature of Relatedness, or What Kind of Related Variety for Long‐Term Regional Growth
Authors: Kuusk Kadri , Martynovich Mikhail 
Published: June 2020

AbstractWe challenge the currently dominating static view of inter‐industry relatedness by investigating the evolution of relatedness linkages between Swedish industries during five sub‐periods between 1991 and 2010. Distinguishing between stable ties (present in all sub‐periods) and non‐stable ties (e.g. emerging, disappearing, etc.), we demonstrate that inter‐industry relatedness linkages change considerably over time. Furthermore, we show that these changes matter for how the co‐location of related industries (related variety) influences regional employment growth – to generate growth the type of local related ties should match with the regional setting. We suggest that, at least partly, the impact of emerging, stable and disappearing ties differs since complementarity potential between related industries becomes depleted over time. In other words, relatedness linkages have a ‘best before date’.
Characterization of the diversification of phospholipid:diacylglycerol acyltransferases in the green lineage
Authors: Falarz Lucas J. , Xu Yang , Caldo Kristian Mark P. , Garroway Colin J. , Singer Stacy D. , Chen Guanqun 
Published: June 2020

SUMMARYTriacylglycerols have important physiological roles in photosynthetic organisms, and are widely used as food, feed and industrial materials in our daily life. Phospholipid:diacylglycerol acyltransferase (PDAT) is the pivotal enzyme catalyzing the acyl‐CoA‐independent biosynthesis of triacylglycerols, which is unique in plants, algae and fungi, but not in animals, and has essential functions in plant and algal growth, development and stress responses. Currently, this enzyme has yet to be examined in an evolutionary context at the level of the green lineage. Some fundamental questions remain unanswered, such as how PDATs evolved in photosynthetic organisms and whether the evolution of terrestrial plant PDATs from a lineage of charophyte green algae diverges in enzyme function. As such, we used molecular evolutionary analysis and biochemical assays to address these questions. Our results indicated that PDAT underwent divergent evolution in the green lineage: PDATs exist in a wide range of plants and algae, but not in cyanobacteria. Although PDATs exhibit the conservation of several features, phylogenetic and selection‐pressure analyses revealed that overall they evolved to be highly divergent, driven by different selection constraints. Positive selection, as one major driving force, may have resulted in enzymes with a higher functional importance in land plants than green algae. Further structural and mutagenesis analyses demonstrated that some amino acid sites under positive selection are critically important to PDAT structure and function, and may be central in lecithin:cholesterol acyltransferase family enzymes in general.