bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post‐transplantation cyclophosphamide versus antithymocyte globulin in patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation from HLA‐identical sibling donors: A retrospective analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Authors: Battipaglia Giorgia , Labopin Myriam , Hamladji Rose‐Marie , Blaise Didier , Chevallier Patrice , Brissot Eolia , Gerbitz Armin , Socié Gerard , Afanasyev Boris , Ciceri Fabio , Meijer Ellen , Koc Yener , Cornelissen Jan J. , Huynh Anne , Ozdogu Hakan , Maertens Johan , Paul Franciane , Labussière‐Wallet Hélène , Ruggeri Annalisa , Aljurf Mahmoud , Bazarbachi Ali , Savani Bipin , Nagler Arnon , Mohty Mohamad 
Published: October 2020

BACKGROUNDGraft‐versus‐host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Addition of antithymocyte globulin (ATG) or post‐transplantation cyclophosphamide (PTCY) to standard immunosuppressive agents reduces GVHD in different donor settings.METHODSWe compared the outcomes of adults with acute myeloid leukemia undergoing allo‐HSCT from HLA‐identical sibling donors after the use of PTCY (n = 197) or ATG (n = 1913).RESULTSPatients in the PTCY group were younger than those in the ATG group (median age, 47 vs 54 years; P < .01). Peripheral blood was the most frequently used stem cell source, being significantly more frequent in the ATG group than in the PTCY group (95% vs 70% P < .01). The conditioning regimen was more frequently myeloablative in the PTCY group than in the ATG group (59% vs 48%; P < .01). Time to neutrophil engraftment was shorter in the ATG group than in the PTCY group (17 vs 20 days; P < .01). No differences were observed according to the other transplantation outcomes, except for chronic GVHD of all grades and extensive chronic GVHD at 2 years, which were significantly lower in the ATG group compared with the PTCY group (P < .02).CONCLUSIONPTCY is feasible in an HLA‐identical sibling setting, and despite similar outcomes, ATG may be associated with lower incidence of chronic GVHD.
Comparative efficacy of chemoimmunotherapy versus immunotherapy for advanced non–small cell lung cancer: A network meta‐analysis of randomized trials
Authors: Pathak Ranjan , De Lima Lopes Gilberto , Yu Han , Aryal Madan Raj , Ji Wenyan , Frumento Katherine Stemmer , Wallis Christopher J. D. , Klaassen Zachary , Park Henry S. , Goldberg Sarah B. 
Published: October 2020

BackgroundTo the authors' knowledge, in the absence of head‐to‐head trials, it is unclear whether chemoimmunotherapy provides an additional overall survival (OS) benefit compared with immunotherapy alone in the first‐line treatment of patients with advanced non–small cell lung cancer (NSCLC). The authors conducted a systematic literature review and network meta‐analysis (NMA) to compare the efficacy of chemoimmunotherapy versus ICI.MethodsMEDLINE, Excerpta Medica dataBASE (EMBASE), Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to April 2020. Phase 3 trials evaluating the efficacy of first‐line ICI or chemoimmunotherapy and reporting efficacy outcomes (OS, progression‐free survival [PFS], and the overall response rate [ORR]) stratified by programmed death–ligand 1 (PD‐L1) status were included. NMA with a Bayesian random effects model was performed.ResultsA total of 12 eligible trials comprising 7845 patients were included. In patients who were negative for PD‐L1 (tumor proportion score [TPS] <1%), NMA comparing chemoimmunotherapy with dual‐agent ICI failed to demonstrate a statistically significant difference with regard to OS, PFS, or the ORR. In patients with low PD‐L1 (TPS 1%‐49%), there was no statistically significant difference observed between chemoimmunotherapy compared with either single‐agent ICI or dual‐agent ICI with regard to OS or the ORR. In patients with high PD‐L1 (TPS ≥50%), chemoimmunotherapy was found to be associated with an improved PFS and ORR compared with single‐agent ICI, but not with dual‐agent ICI. No differences in OS were observed with chemoimmunotherapy when compared with either single‐agent or dual‐agent ICIs.ConclusionsAlthough chemoimmunotherapy appears to improve the ORR and PFS in patients with PD‐L1–high tumors when compared with single‐agent ICI, it does not appear to confer an OS benefit over single‐agent or dual‐agent ICI for patients with advanced NSCLC regardless of PD‐L1 status. Prospective trials are needed to validate these findings.
Utilization of cytology smears improves success rates of RNA‐based next‐generation sequencing gene fusion assays for clinically relevant predictive biomarkers
Authors: Ramani Nisha S. , Chen Hui , Broaddus Russell R. , Lazar Alexander J. , Luthra Rajyalakshmi , Medeiros L. Jeffrey , Patel Keyur P. , Rashid Asif , Routbort Mark J. , Stewart John , Tang Zhenya , Bassett Roland , Manekia Jawad , Barkoh Bedia A. , Dang Hyvan , Roy‐Chowdhuri Sinchita 
Published: October 2020

BackgroundThe use of RNA‐based next‐generation sequencing (NGS) assays to detect gene fusions for targeted therapy has rapidly become an essential component of comprehensive molecular profiling. For cytology specimens, the cell block (CB) is most commonly used for fusion testing; however, insufficient cellularity and/or suboptimal RNA quality are often limiting factors. In the current study, the authors evaluated the factors affecting RNA fusion testing in cytology and the added value of smears in cases with a suboptimal or inadequate CB.MethodsA 12‐month retrospective review was performed to identify cytology cases that were evaluated by a targeted RNA‐based NGS assay. Samples were sequenced by targeted amplicon‐based NGS for 51 clinically relevant genes on a proprietary platform. Preanalytic factors and NGS quality parameters were correlated with the results of RNA fusion testing.ResultsThe overall success rate of RNA fusion testing was 92%. Of the 146 cases successfully sequenced, 14% had a clinically relevant fusion detected. NGS testing success positively correlated with RNA yield (P = .03) but was independent of the tumor fraction, the tumor size, or the number of slides used for extraction. CB preparations were adequate for testing in 45% cases, but the inclusion of direct smears increased the adequacy rate to 92%. There was no significant difference in testing success rates between smears and CB preparations.ConclusionsThe success of RNA‐based NGS fusion testing depends on the quality and quantity of RNA extracted. The use of direct smears significantly improves the adequacy of cytologic samples for RNA fusion testing for predictive biomarkers.
Spatially and Temporally Resolved Measurements of NO Adsorption/Desorption over NOx‐Storage Catalyst
Authors: Wan Sui , Guo Yiran , Häber Thomas , Suntz Rainer , Deutschmann Olaf 
Published: October 2020

AbstractThe two‐dimensional (2D) temporal evolution of the NO‐concentration over a NOx‐storage catalyst is investigated in situ with planar laser‐induced fluorescence (PLIF) in an optically accessible parallel wall channel reactor. Signal accumulated phase‐correlated 2D‐recordings of repetitive adsorption/desorption cycles are obtained by synchronizing the switching of the NO gas flow (on/off) with the laser and detection system, thereby significantly increasing the signal‐to‐noise ratio. The gas compositions at the reactor outlet are additionally monitored by ex‐situ analytics. The impacts of varying feed concentration, temperature and flow velocities are investigated in an unsteady state. Transient kinetics and the mass transfer limitations can be interpreted in terms of the NO concentration gradient changes. The technique presented here is a very useful tool to investigate the interaction between surface kinetics and the surrounding gas flow, especially for transient catalytic processes.
Effects of Protein and Calorie Restriction on the Metabolism and Toxicity Profile of Irinotecan in Cancer Patients
Authors: de Man Femke M. , van Eerden Ruben A.G. , van Doorn Gerdien M. , Oomen‐de Hoop Esther , Koolen Stijn L.W. , Olieman Joanne F. , de Bruijn Peter , Veraart Joris N. , van Halteren Henk K. , Sandberg Yorick , Moelker Adriaan , IJzermans Jan N.M. , Lolkema Martijn P. , van Gelder Teun , Dollé Martijn E.T. , de Bruin Ron W.F. , Mathijssen Ron H.J. 
Published: October 2020

Preclinical data suggests that protein and calorie restriction (PCR) might improve treatment tolerability without impairing antitumor efficacy. Therefore, we have studied the influence of PCR on irinotecan pharmacokinetics and toxicity. In this crossover trial, patients with liver metastases of solid tumors were included and randomized to treatment with irinotecan preceded by 5 days of PCR (~ 30% caloric and ~ 70% protein restriction) during the first cycle and a second cycle preceded by a normal diet or vice versa. Pharmacokinetic blood sampling and biopsies of both healthy liver and liver metastases were performed. The primary end point was the relative difference in geometric means for the active metabolite SN‐38 concentration in healthy liver analyzed by a linear mixed model. No significant differences were seen in irinotecan (+ 16.8%, P = 0.22) and SN‐38 (+ 9.8%, P = 0.48) concentrations between PCR and normal diet in healthy liver, as well as in liver metastases (irinotecan: −38.8%, P = 0.05 and SN‐38: −13.8%, P = 0.50). PCR increased irinotecan plasma area under the curve from zero to 24 hours (AUC0–24h) with 7.1% (P = 0.04) compared with normal diet, whereas the SN‐38 plasma AUC0–24h increased with 50.3% (P < 0.001). Grade ≥ 3 toxicity was not increased during PCR vs. normal diet (P = 0.69). No difference was seen in neutropenia grade ≥ 3 (47% vs. 32% P = 0.38), diarrhea grade ≥ 3 (5% vs. 21% P = 0.25), and febrile neutropenia (5% vs. 16% P = 0.50) during PCR vs. normal diet. In conclusion, plasma SN‐38 exposure increased dramatically after PCR, whereas toxicity did not change. PCR did not alter the irinotecan and SN‐38 exposure in healthy liver and liver metastases. PCR might therefore potentially improve the therapeutic window in patients treated with irinotecan.
Population Pharmacokinetics of Trastuzumab Deruxtecan in Patients With HER2‐Positive Breast Cancer and Other Solid Tumors
Authors: Yin Ophelia , Xiong Yuan , Endo Seiko , Yoshihara Kazutaka , Garimella Tushar , AbuTarif Malaz , Wada Russ , LaCreta Frank 
Published: October 2020

Trastuzumab deruxtecan (DS‐8201) is a human epidermal growth factor receptor 2 (HER2)–targeting antibody–drug conjugate with a novel enzyme‐cleavable linker, a topoisomerase I inhibitor payload, and a drug‐to‐antibody ratio of ≈ 8. We have characterized the population pharmacokinetics (PK) of trastuzumab deruxtecan and released drug (topoisomerase I inhibitor) in patients with HER2‐positive breast cancer or other solid tumor malignancies. This analysis includes pooled data from five clinical studies with 639 patients. Trastuzumab deruxtecan doses ranged from 0.8 to 8.0 mg/kg every 3 weeks. Serum concentrations of trastuzumab deruxtecan and released drug were analyzed using a sequential two‐step approach, with the nonlinear mixed‐effects modeling methods. Covariate assessment was based upon stepwise forward‐addition and backward‐elimination process, followed by both univariate and multivariate analysis quantifying their impact on steady‐state exposure of trastuzumab deruxtecan and released drug. A two‐compartment model with linear elimination best described PK profiles of intact trastuzumab deruxtecan, while a one‐compartment model with time‐varying release‐rate constant and linear elimination described released‐drug PK profiles. Statistically significant covariates (country, tumor size, sex, formulation, age, body weight, albumin, total bilirubin, and aspartate aminotransferase) resulted in < 20% change in steady‐state area under the concentration‐time curve of trastuzumab deruxtecan and released drug, except for increased body weight (95th percentile, 86 kg) and decreased albumin (5th percentile, 31 g/L). Analysis of patients stratified by country, race, renal function, and hepatic function found no clinically meaningful differences in steady‐state exposure of intact trastuzumab deruxtecan or released drug. Overall, results suggest that no dose adjustment based on tested covariates or in specific patient populations is warranted.
Concordance ofHPV, conventional smear, colposcopy, and conization results in cervical dysplasia
Authors: Aydogan Kirmizi Demet , Baser Emre , Demir Caltekin Melike , Onat Taylan , Sahin Sevinc , Yalvac Ethem Serdar 
Published: October 2020

AbstractBackgroundCervical cancer screening algorithms are increasingly focused on Human Papillomavirus (HPV)‐based screening while the accuracy of using abnormal cytological findings to detect dysplastic lesions still remains important. This retrospective study correlated the results of conventional cervical cytology, colposcopy guided biopsy, and cold knife conization (CKC) procedures performed in a tertiary center.Materials and MethodsData from 9399 patients who underwent screening with conventional cervical cytology between 2010 and 2019 was obtained from the hospital registry. Abnormal cervical cytology and high‐risk HPV DNA genotypes were recorded and their colposcopic and CKC pathology was determined.ResultsTwo hundred and ninety two patients underwent colposcopy for abnormal cervical cytology and/or high‐risk HPV positivity. One hundred and twenty three patients were positive for High‐risk HPV. Abnormal cervical cytology was detected in 216 patients. The most common cytological anomaly was atypical squamous cells of undetermined significance (ASCUS) found in 9399 patients (1.39%). It was determined that conventional cytology had a sensitivity of 70.8% and a specificity of 62.2% for the detection of low‐grade lesions, while it had a sensitivity of 72.4% and a specificity of 86.0% for the detection of high‐grade lesions. CKC was applied to 68 patients who were diagnosed with high‐grade squamous intraepithelial lesions (HSIL) as a result of the colposcopy. As a result of CKC, a high‐grade lesion was detected in 73.5% of these patients.ConclusionConventional cervical cytology and colposcopy exhibited higher accuracy as the severity of lesions increased. Detection of HPV may prevent unnecessary surgical procedures, especially with ASCUS.
Predictors of treatment response durability in psychotherapy for binge‐eating disorder: Examining the roles of self‐discrepancy, self‐directed style, and emotion dysregulation
Authors: Hazzard Vivienne M. , Peterson Carol B. , Crosby Ross D. , Schaefer Lauren M. , Smith Kathryn E. , Engel Scott G. , Crow Scott J. , Wonderlich Stephen A. 
Published: October 2020

AbstractObjectiveTo examine changes in hypothesized maintenance mechanisms during treatment as predictors of treatment response durability in binge‐eating disorder (BED) treatment, using data from a randomized clinical trial comparing the efficacy of Integrative Cognitive‐Affective Therapy for BED with cognitive‐behavioral therapy delivered using guided self‐help.MethodAdults with BED (N = 112) received 17 weeks of treatment. Regression models were conducted to examine the extent to which changes in hypothesized maintenance mechanisms from baseline to end of treatment predicted treatment outcomes at 6‐month follow‐up, adjusting for demographics, study site, and baseline level of treatment outcome.ResultsDuring‐treatment reductions in negative self‐directed style and emotion dysregulation predicted reductions in the primary treatment outcome (i.e., binge‐eating episode frequency) at follow‐up. During‐treatment reductions in emotion dysregulation also predicted improvements at follow‐up across all three secondary treatment outcomes examined (i.e., global eating disorder [ED] psychopathology, depressive symptoms, and anxiety symptoms), as did during‐treatment reductions in actual‐ideal self‐discrepancy and actual‐ought self‐discrepancy. Increases in positive self‐directed style (e.g., self‐affirmation) and reductions in negative self‐directed style (e.g., self‐blame) during treatment each predicted improvements in anxiety symptoms at follow‐up. When predictors were examined simultaneously, the most salient predictors of treatment response durability identified were negative self‐directed style for binge‐eating episode frequency, actual‐ought self‐discrepancy and emotion dysregulation for depressive symptoms, and emotion dysregulation for anxiety symptoms. No predictors emerged as most salient for global ED psychopathology.DiscussionResults indicate that negative self‐directed style and emotion dysregulation are particularly important treatment targets in relation to behavioral treatment outcomes in BED.
Predicting greater sage‐grouse habitat selection at the southern periphery of their range
Authors: Picardi Simona , Messmer Terry , Crabb Ben , Kohl Michel , Dahlgren David , Frey Nicki , Larsen Randy , Baxter Rick 
Published: October 2020

AbstractMapping suitable habitat is an important process in wildlife conservation planning. Species distribution reflects habitat selection processes occurring across multiple spatio‐temporal scales. Because habitat selection may be driven by different factors at different scales, conservation planners require information at the scale of the intervention to plan effective management actions. Previous research has described habitat selection processes shaping the distribution of greater sage‐grouse (Centrocercus urophasianus; sage‐grouse) at the range‐wide scale. Finer‐scale information for applications within jurisdictional units inside the species range is lacking, yet necessary, because state wildlife agencies are the management authority for sage‐grouse in the United States. We quantified seasonal second‐order habitat selection for sage‐grouse across the state of Utah to produce spatio‐temporal predictions of their distribution at the southern periphery of the species range. We used location data obtained from sage‐grouse marked with very‐high‐frequency radio‐transmitters and lek location data collected between 1998 and 2013 to quantify species habitat selection in relation to a suite of topographic, edaphic, climatic, and anthropogenic variables using random forest algorithms. Sage‐grouse selected for greater sagebrush (Artemisia spp.) cover, higher elevations, and gentler slopes and avoided lower precipitations and higher temperatures. The strength of responses to habitat variables varied across seasons. Anthropogenic variables previously reported as affecting their range‐wide distribution (i.e., roads, powerlines, communication towers, and agricultural development) were not ranked as top predictors at our focal scale. Other than strong selection for sagebrush cover, the responses we observed differed from what has been reported at the range‐wide scale. These differences likely reflect the unique climatic, geographic, and topographic context found in the southern peripheral area of the species distribution compared to range‐wide environmental gradients. Our results highlight the importance of considering appropriateness of scale when planning conservation actions for wide‐ranging species.
Prediction of worsening heart failure events and all‐cause mortality using an individualized risk stratification strategy
Authors: Zile Michael R. , Koehler Jodi , Sarkar Shantanu , Butler Javed 
Published: October 2020

AbstractAimsThis study aimed to examine the clinical utility of a multisensor, remote, ambulatory diagnostic risk score, TriageHF™, in a real‐world, unselected, large patient sample to predict heart failure events (HFEs) and all‐cause mortality.Methods and resultsTriageHF risk score was calculated in patients in the Optum® database who had Medtronic implantable cardiac defibrillator device from 2007 to 2016. Patients were categorized into three risk groups based on probability for having an HFE within 6 months (low risk <5.4%, medium risk ≥5.4 < 20%, and high risk ≥20%). Data were analysed using three strategies: (i) scheduled monthly data download; (ii) alert‐triggered data download; and (iii) daily data download. Study population consisted of 22 901 patients followed for 1.8 ± 1.3 years. Using monthly downloads, HFE risk over 30 days incrementally increased across risk categories (odds ratio: 2.8, 95% confidence interval: 2.5–3.2 for HFE, P < 0.001, low vs. medium risk, and odds ratio: 9.2, 95% confidence interval: 8.1–10.3, P < 0.001, medium vs. high risk). Findings were similar using the other two analytic strategies. Using a receiver operating characteristic curve analysis, sensitivity for predicting HFE over 30 days using high‐risk score was 47% (alert triggered) and 51% (daily download) vs. 0.5 per patient year unexplained detection rate. TriageHF risk score also predicted all‐cause mortality risk over 4 years. All‐cause mortality risk was 14% in low risk, 20% in medium risk, and 38% in high risk.ConclusionsTriageHF risk score provides a multisensor remote, ambulatory diagnostic method that predicts both HFEs and all‐cause mortality.
Thermal performance of a thermal management system with a thin plate and a slender tube for prismatic batteries
Authors: Tang Zhiguo , Li Jie , Liu Zhiqing , Cheng Jianping 
Published: October 2020

SummaryThe temperature of high‐power lithium‐ion batteries has a great influence on their performance, safety, and stability; thus the battery thermal management system (BTMS) is a key component of electric vehicles. In this paper, a novel liquid‐cooling BTMS with a thin plate and a slender tube is proposed for prismatic batteries, four different cooling structures of the tube are designed to achieve a high temperature uniformity, and a three‐dimensional numerical model is established. The effects of different cooling structures, battery discharge rates, coolant inlet velocities and inner diameters of the slender tube on the thermal performance are investigated. The results indicate that design S3, for which the length of the effective heat transfer tube distributed by each battery increases gradually along the flow direction of the coolant, exhibits the best thermal management performance among the four designed cooling structures, especially in terms of the temperature uniformity. When the inner diameter of the slender tube is 2 mm and the inlet velocity is not less than 0.5 m/s, the maximum temperature difference between the batteries is reduced to 4.23°C at a 2C discharge rate. This study can provide guidance for the structural design of BTMSs for prismatic batteries.
TiO2 nanotubes for dye‐sensitized solar cells—A review
Authors: Hou Xuelan , Aitola Kerttu , Lund Peter D. 
Published: October 2020

AbstractTiO2 nanotubes (TNTs) are a potential candidate for the photoelectrode in dye‐sensitized solar cells (DSSCs). In this review, emphasis is given to the fabrication methods of the TNT photoelectrode, including the anodic oxidation method, the hydro/solvothermal method, and the template method. Modification of TNTs to improve the power conversion efficiency (PCE) and the long‐term stability of DSSCs is also covered. The active area of the DSSC strongly correlates with the PCE. Therefore, evaluating and comparing cell efficiencies with the same active area would be important. Reducing the material and manufacturing costs of TNT‐based DSSCs will be an important future target.