bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term impact of adherence to muscle-strengthening guidelines on inflammation markers: a 17-year follow-up study with obesity parameters as mediators
Authors: Garcia-Hermoso Antonio , Ezzatvar Yasmin , Yáñez-Sepúlveda Rodrigo , Olivares-Arancibia Jorge , Páez-Herrera Jacqueline , López-Gil José Francisco 
Published: December 2024

ObjectiveTo evaluate the relationship between adherence to muscle-strengthening guidelines in young adulthood and inflammation markers over a 17-year follow-up period. Additionally, it aims to examine whether body mass index (BMI) and waist circumference (WC) act as mediators in this relationship.MethodsThe study analysed data from young adults aged 18–26 years who participated in waves III (2001–2002), IV (2008–2009) and V (2016–2018) of the Add Health Study. Adherence to muscle-strengthening guidelines was self-reported, and participants were classified as adherent if they engaged in strength training ≥2 days per week across all waves. Venous blood samples were collected at participants’ homes to measure high-sensitivity C reactive protein (hs-CRP) levels and various cytokine concentrations, including interleukin (IL)−6, IL-1beta, IL-8, IL-10 and tumour necrosis factor-alpha (TNF-α). A global inflammation score was also calculated using z-scores of these markers.ResultsA total of 2320 individuals participated (60.8% females). Participants adhering to muscle-strengthening guidelines exhibited significant reductions in hs-CRP, IL-6 and the inflammation z-score, with mean difference (MD) of −1.556 mg/L (95% CI BCa −2.312 to −0.799), −0.324 pg/mL (95% BCa CI −0.586 to −0.062), and −0.400 (95% BCa CI −0.785 to −0.035), respectively. Mediation analysis revealed that BMI and WC levels at wave V significantly mediated the relationship between strength training and inflammation z-score, with significant indirect effects of −0.142 (95% CI −0.231 to −0.055) for BMI and −0.210 (95% CI −0.308 to −0.124) for WC.ConclusionAdherence to muscle-strengthening guidelines alone may not be sufficient to achieve a notable decrease in inflammation without concurrent reductions in these obesity parameters.
Comparative estimate of glucose-lowering therapies on risk of incident pneumonia and severe sepsis: an analysis of real-world cohort data
Authors: Henney Alex E , Riley David R , Hydes Theresa J , Anson Matthew , Ibarburu Gema H , Frost Frederick , Alam Uazman , Cuthbertson Daniel J 
Published: December 2024

Background
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are treatments for type 2 diabetes (T2D). Beyond glucose-lowering and cardiorenal protection, these drugs may protect against pneumonia and sepsis.

Aims
This study assesses the impact of SGLT2i and GLP-1 RAs on the risk of incident pneumonia and severe sepsis.

Methods
A retrospective cohort study was conducted using anonymised electronic medical records from TriNetX, a global federated database. Two intention-to-treat analyses were performed, each with two cohorts of adult T2D patients. The first analysis compared individuals prescribed SGLT2i, and the second individuals prescribed GLP-1 RAs, with those prescribed dipeptidyl peptidase-4 inhibitors (DPP-4i). An active comparator new user design was used, with outcomes defined as time-to-incident pneumonia and severe sepsis. Propensity score matching (1:1) was applied to control for potential confounders, and patients were followed for 12 months. Secondary analyses compared SGLT2i and GLP-1 RAs against other glucose-lowering therapies.

Results
After propensity score matching, 352 687 patients were included in the SGLT2i versus DPP-4i comparison. SGLT2i treatment was associated with a risk reduction in incident pneumonia (HR 0.75 (95% CI 0.73, 0.78)) and severe sepsis (0.75 (0.73, 0.77)). In the GLP-1 RA versus DPP-4i comparison, 331 863 patients were included. GLP-1 RA treatment was associated with a risk reduction in incident pneumonia (0.60 (0.58, 0.62)) and severe sepsis (0.61 (0.59, 0.63)).

Conclusion
SGLT2i and GLP-1 RAs are associated with a reduced risk of incident pneumonia and severe sepsis in patients with T2D. Further research and focused randomised controlled trials are warranted to explore the broader clinical implications of these treatments.
Evolution of whole blood trauma resuscitation in childbearing age females: practice patterns and trends
Authors: Brito Alexandra MP , Yazer Mark H , Sperry Jason L , Luther James F , Wisniewski Stephen R , Guyette Frances , Moore Ernest E , Cotton Bryan A , Vincent Laura , Fox Erin , Cannon Jeremy W , Namias Nicholas , Minei Joseph P , Ammons Lee Anne , Clayton Skye , Schreiber Martin 
Published: December 2024

BackgroundThe use of low titer group O whole blood (LTOWB) for resuscitation of patients with traumatic hemorrhage is becoming increasingly common. Practices regarding the administration of RhD-positive LTOWB to childbearing age females (CBAFs) vary between institutions due to concerns about RhD alloimmunization. This study examined practices related to LTOWB transfusion as they pertain to age and sex.MethodsThis was a secondary analysis of the Shock, Whole blood, and Assessment of TBI (traumatic brain injury) trial, a prospective, multicenter observational cohort study where outcomes following LTOWB transfusion were analyzed at seven level 1 trauma centers between 2018 and 2021, as well as a survey on transfusion practices at these centers conducted in 2023. The proportion of patients who received LTOWB or components was examined over the course of the study and grouped by age and sex, and the RhD group of injured CBAFs was documented.ResultsA total of 1046 patients were evaluated: 130 females aged <50 years (CBAFs), 77 females aged ≥50 years; 661 males aged <50 years, and 178 males aged ≥50 years. Among them, 26.2% of CBAFs received RhD-positive LTOWB, whereas 57.1%–66.3% of other sex/age groups received LTOWB. The proportion of CBAFs who received LTOWB increased significantly throughout the 4 years of this study. Except for older women in years 2 and 4, CBAFs were significantly less likely to receive LTOWB than all other groups for the study period and individual years. Among the 33 CBAFs who received LTOWB and for whom an RhD type was available, 4/33 (12.1%) were RhD-negative, while 9/95 (9.5%) CBAFs who received component therapy were RhD-negative. RhD blood product selection practices varied considerably between institutions.ConclusionsMany institutions transfused LTOWB to CBAFs. Policies regarding RhD product selection varied. Of the total cohort, the proportion of RhD-negative CBAFs who received LTOWB increased over time but remained lower than all other groups.Level of evidence3.
Impact of a hybrid coating REBCO-CC-Cu to the resistive wall beam impedance of the FCC-hh beam screen
Authors: Tagdulang Nikki , Günzel Thomas , Krkotić Patrick , Calatroni Sergio , O’Callaghan Juan Manuel , Pont Montse 
Published: December 2024

AbstractThe Future Circular Hadron Collider design studies proposed a novel dual chamber beam screen consisting of copper and stainless steel. However, one concern about the current design is the inherent resistive wall beam impedance of the beam screen, which may not be low enough to guarantee stable beam operation especially critical on the vertical plane. In order to reduce the resistive wall beam impedance as much as possible while keeping the dipole field quality within specifications, a hybrid beam screen consisting of REBCO-CC and Cu is proposed for the inner chamber of the beam screen. We performed a comprehensive position and REBCO-CC content study, leading to an optimum configuration for a REBCO-CC-Cu hybrid design. These studies utilized measured values of REBCO-CC surface impedance obtained under realistic FCC-hh conditions. The calculations were carried out by combining numerical simulations and beam coupling impedance theory for general beam pipe cross sections, where we found a substantial decrease in the vertical resistive wall beam impedance by about an order of magnitude compared to the nominal beam screen design made of copper. Limitations of the proposed design and possible mitigation actions are also discussed.
Distributive Preferences and Fair Water Sharing among Farmers in India
Authors: Ouvrard Benjamin , Reynaud Arnaud , Sivamurthy Murudaiah 
Published: December 2024

Using an experimental setting inspired by the empirical social choice literature, we analyze how Indian farmers define fair water allocation. We investigate the choices of 240 Indian farmers who — as a neutral third-party — are asked to make water allocation decisions in situations that differ, such as the agricultural area in which each farmer grows crops, the responsibilities of farmers in each agricultural area, and the nature of their water resource (lake versus river). Our findings highlight the impact of contextual variables: respondents tend to endorse equal water distribution when farmers have identical land sizes but lean toward proportional allocation when differences in land size exist. However, this inclination toward proportional allocation diminishes when discrepancies in land size result from farmers’ own decisions rather than external factors. Additionally, we uncover indications of a link between farmers’ inclinations toward pro-social behavior and their preference for proportional allocation.
Tradition and Modernity in the History of Pop-Rock and Semba
Authors: Gomes Pedro David 
Published: December 2024

Abstract
The colonial authorities in Angola employed the modern/traditional dichotomy to classify and frame musical styles such as semba and pop-rock. What would later be called semba was labeled as ‘folklore’, while pop-rock was considered ‘modern music’. This categorisation reinforced the binaries of the European centre/modern city versus the slums (musseques)/space of African tradition. Such classification was part of a folklorisation process imposed by the state, aiming at exerting a certain degree of control over the music produced by non-Europeans. Drawing on written, visual, and primarily oral archives, this research demonstrates that the popularisation of semba throughout the city compelled colonial officials to rearticulate these binary divisions in conjunction with the promotion of the imperial “Portuguese” culture.
The Delitiae CC Italorum Poetarum (1608) Edited by Jan Gruter, Its Sources and Models
Authors: Lucioli Francesco 
Published: December 2024

Abstract
Delitiae CC Italorum poetarum huius superiorisque aevi illustrium is the title of a two-volume anthology of Neo-Latin poetry which collects texts by more than two hundred Italian authors. Published in 1608 by the Flemish philologist Jan Gruter, this collection establishes a canon of Neo-Latin poetry written in Italy in the sixteenth century. With his anthology Gruter aimed to complete a project already undertaken by Giovanni Matteo Toscano, who had published in Paris, between 1576 and 1577, a two-volume collection of Carmina illustrium poetarum Italorum. The two anthologies differ in the number of chosen authors and selected texts, but above all in the way they choose them. By comparing the two collections of poems, this contribution aims to highlight the strategies adopted by Gruter to establish his canon of Italian authors of Neo-Latin poetry, and to discuss the different sources he used to build his anthology.
Beyond the Canon
Authors: Zucchi Enrico 
Published: December 2024

Abstract
While studying the role of sixteenth-century poetry anthologies in the emergence of European national literatures, the Italian case stands out with particular relevance for different reasons. First, they created a common poetic language spreading all over the nation the model of Petrarch’s Rerum Vulgarium Fragmenta. Secondly, especially in Venice, lyrical anthologies were amongst the most popular editorial products, and often publishers cobbled together lyrical texts written by different poets, creating bestsellers that influenced significantly the early modern poetical canon. Yet, the sixteenth-century vernacular anthologies did not only play an authoritative role in the development of the Italian poetical canon. They were sometimes also an instrument to dissent from that canon, promoting linguistic and thematic choices that were not mainstream. This article deals with the tradition of the Rime piacevoli, a series of lyrical anthologies published in the second part of the sixteenth century, that challenged, often ironically, the contemporary canonical poetry anthologies. The aim of the article is to explore a neglected use of the vernacular poetry anthology both from a literary and a commercial perspective, surveying the way they interact with the “canonical” anthologies, and studying their wide circulation and editorial success.
Creating a Nation through an Anthology of Neo-Latin Poetry
Authors: Storchová Lucie 
Published: December 2024

Abstract
Farragines poematum, an extensive, four-volume anthology of Neo-Latin poems, was published in 1561–1562 by a group of former Wittenberg students based in Prague. This study focuses on how this collective literary project originated, how the anthology was prepared and what reasons poets might have had for publishing a representative selection of their own works of poetry and their friends’. It demonstrates how the final form of the anthology was influenced by the strategies of gaining patronage. Following the concepts of Caspar Hirschi, this study discusses which role anthology, as a specific literary type, could have played in the early stages of the Humanist ‘competition for national honour’, how it presents the community of poets in the Bohemian lands and the spread of education from Italy to the Transalpine regions to prove the quality of local scholars.
Altitude differences impact gene expression and accumulation of main medicinal ingredients of Zanthoxylum planispinum var. Dintanensis in rocky desertification control areas
Authors: Wang Jiyue , Liu Zhenghong , Yu Yanghua , Liao Shanggao , Peng Zele , Yang Xiaosheng 
Published: December 2024

Abstract
Environmental factors such as altitude may significantly influence both the morphological trait and accumulation of metabolite products in plant. In present study, gene expression profiles of Z. planispinum var. Dintanensisin grown at different altitude (A1:1054 m.a.s.l., A2:821 m.a.s.l., A3:645 m.a.s.l.) were generated by using RNA-Seq. Four main medicinal ingredients of peels were determined, including the total acylamide, total flavonoids, total alkaloids and volatile oil content. The results showed that a total of 10,703 differentially expressed genes (DEGs) were identified among the three samples (A1, A2, A3), of these, 315 DEGs were putative transcription factors (TFs) belonging to 74 TF families. In particular, some candidate genes related to accumulation of main medicinal ingredients have been screened through combining Kmeans cluster and KEGG enrichment analysis. Besides, the total flavonoid accumulation exhibited a positive correlation with increasing altitude, suggesting that higher altitudes favor metabolite accumulation. Notably, seven genes and one MYB TF involved in the biosynthesis of the main medicinal ingredients were confirmed through RT-qPCR analysis The data obtained in this study offers a global survey of gene expression patterns of Z. planispinum var. Dintanensis grown in rocky desertification control areas, which support for further research on the high-altitude adaptation mechanism and identification of peels with higher medicinal value.
The Glorious Qurʾan and Distortion in Its Interpretation in Malaysia: a Solution in the Views of Muslim Exegetes
Authors: Abdullah Mustaffa , Gokaru Shuaibu Umar , Mohd Nor Mohd Roslan , Amir Selamat bin , Norasid Muhamad Alihanafiah bin 
Published: December 2024

Abstract
Currently, distortion in the interpretation of the Glorious Qurʾan is one of the biggest issues that is alarming in the Muslim World and Malaysia is no exception, where Kasim Ahmad is known for the anti-Hadith of the Prophet, and Political activist Leen who was actively involved in such practices. This issue has triggered enthusiasm among Muslim scholars, particularly the Muslim Exegetes who heavily debated it. To address this issue, this article examines the views of Muslim Exegetes. Data in this study were collected from the critical evaluation of some identified interpreted verses of the Glorious Qurʾan by those figures in Malaysia and others in the world, including the most powerful organizations such as Sister in Islam (SIS), Millah Ibrahim, and LGBT Groups and their proponents like Amreen Jamal, Hassan El-Menyawi, and prolific writer Dervla Shannahan. Through in-depth analysis to provide a lasting solution to ensure the accuracy of the interpretation of the Glorious Qurʾan, this study solely relied on the explanation and comments from the books of the most renowned Qurʾan commentators (Mufassirun) such as Ibn Kathir, Imam ʿAbd al-Rahman as-Saʾdi, Imam Al-Shawkani, Al-Maraghi, and Ibn Atiyyah. This study finally argues that the lack of using multiple Qurʾan exegesis and consulting experts in the field, as well as the knowledge of the Arabic language, were the main reasons for distortion in the interpretation of the verses of the Qurʾan. By addressing these issues, distortions, and deviations in the interpretations of the Glorious Qurʾan can be solved, and its accurate teachings can be preserved for generations to come.
Neuroprotective effect of mealworm protein hydrolysate-derived bioactive peptides in human microglial cells
Authors: Gonzalez-de la Rosa T. , del Valle-Alonso M.A. , Montserrat de la Paz S. , Rivero-Pino F. 
Published: December 2024

Abstract
The larva of Tenebrio molitor, better known as mealworm, is one of the most studied insects today, since it was recently classified as safe for human consumption. Specifically, its high protein content makes it a splendid candidate for the search for bioactive peptides, with properties ranging from anti-inflammatory to neuroprotective. In this study, the effect of a digested hydrolysate on microglia cells (which previously demonstrated high anti-inflammatory activity in intestinal CACO-2 cells) was analysed, specifically on their levels of gene expression of various cytokines, such as IL-6, IL-10, or IL-1β, among others. In addition, four chemically synthesised peptides, selected from this digested hydrolysate based on in silico analysis, including the estimation of the bioactive properties of these peptides, their physicochemical properties and their toxicokinetic, were evaluated in the microglia cells as well. In addition, molecular docking assays of the peptides were performed with two receptors relevant to inflammation. Relevant changes in the expression of IL-6, IL-1β, and BDNF were observed due to the action of the peptides, especially in the case of IYVDAVIN and SLPSLPEPV. These results provide an insight on how specific peptides found in Tenebrio molitor could be used as therapeutics agent in the immunomodulation of brain cells.
COVID-19, Frustration of Contracts, and Application of Force majeure in Tanzanian Courts
Authors: Temu Goodluck 
Published: December 2024

Abstract
The 2019 COVID-19 pandemic caused panic, confusion, and frustration. Besides the pressure and stress the pandemic imposed upon healthcare systems, many business owners wondered what would happen to their unfulfilled contractual obligations. What was the likely effect of pending agreements and legally binding commitments if their fulfilment became impossible because of COVID-19 and its effect on business performance and transactions? Could courts of law be of any assistance? Tanzania was not exempt from the effects of the pandemic, so the Tanzanian courts became responsible for interpreting contractual responsibilities of parties affected by COVID-19. Overall, courts proved that when reasonable causes exist, force majeure clauses and the doctrine of frustration of contract can be effectively invoked by the affected party in order to exonerate that agent from pending obligations. On the other hand, courts also demonstrated that they would not accept spurious claims unless it was expressly shown how the performance of a specific contract was made impossible by the pandemic.
Histories of Landscapes: Negotiating Access and Belonging in the Tanganyika–Kenya Borderlands, 1930s to 1960s
Authors: Chuhila Maxmillian Julius 
Published: December 2024

Abstract
Landscapes in the colonial period were contested and negotiated among multiple actors. The differences among them were reflected in the way colonial government authorities and local populations defined what it meant to belong to a physical space. Existing scholarship reveals how pastoralists, for example, were marginalised by successive governments who treated them as threats to the environment in the very regions where they have been recognised independently as essential actors in creating and sustaining those landscapes into the world heritage sites that they have become. While the conflict over various competing uses of land is well represented in the literature, less attention has been paid to how transboundary opportunities and challenges have been appropriated in order to ease the ill effects of resource scarcity in geographical locations which have undergone constant conflicting human interests. Here I address the regions lying between Kenya and Tanganyika. Using examples from pastoralist and farming communities on both sides of the border, this paper analyses the challenges posed by the multiple meanings of ‘landscape’ for transboundary resource use. Drawing upon archives available in Kenya, Tanzania and the United Kingdom, I argue that the borderlines officially dividing Tanganyika from Kenya had little if anything at all to do with the social practices and resources uses that prevailed at the time.
Socio-Ecological Subjectivity in Paschally Mayega’s The People’s Schoolmaster
Authors: Ng’umbi Yunusy Castory 
Published: December 2024

Abstract
Mismanagement of the environment destroys biotic resources including trees, plants, birds, mammals and aquatic species; this forces people to endure contending with material hazards and places human lives at risk. Fiction provides a lens to interrogate the different ways in which environments are imagined, negotiated and used in socio-geographic and political arenas. Mayega’s novella The People’s Schoolmaster problematizes the various factors that victimise humankind ecologically. Relying on Rob Nixon’s concept of ‘slow violence’, I analyse Mayega’s representation of local reactions to global environmental crises; he portrays local publics reacting to political laxity, dishonesty, stinginess and misappropriation of public funds as the major causes of savage environmental destruction.