bluuebunny/crossref_metadata_2025_split huggingface dataset:
Registry Study of Clinical Data and in Hospital Outcome in Patients Admitted with Acute Coronary Syndrome at Tanta University Hospital in 2019
Authors: Helal Doaa Abdelfattah , Taha Fatma Aboalsaoud , Khalel Sameh Samir , Setiha Mohammed Elsayed El 
Published: December 2020

Background: A quick but thorough assessment of the patient’s history and findings on physical examination, electrocardiography, and cardiac biomarker tests permit accurate diagnosis and aid in early risk stratification. This work aimed to analyze the diagnostic and prognostic tools, the modalities of management, and the hospital outcome of patients with acute coronary syndrome (ACS) at Tanta University Hospital in one year.
Methods: This ACS registry at Tanta university hospital is a prospective observational registry for 200 consecutive admitted patients with proven ACS from January 2019 to January 2020.
Results: A higher percent of hypertension, family history of ischemic heart disease and SCD, previous history of chronic kidney disease (CKD), and lower percent of a previous history of IHD in STEMI compared to NSTEMI/UA. In-hospital death, in-hospital reinfarction, and reduced ejection fraction are higher in STEMI than in NSTEMI/UA patients. (P value = 0.015, 0.018 and 0.001 respectively) without significant differences regarding in-hospital congestive heart failure (CHF) and ischemic stroke. History of CKD, higher Killip class, and in-hospital stroke were independently affecting in-hospital mortality. Also, the history of higher Killip class was independently affecting in-hospital reinfarction and in-hospital CHF. Old age and occurrence of in-hospital reinfarction were independently affecting in-hospital stroke.
Conclusion: Hypertension, diabetes, dyslipidemia, and smoking are the major risk factors for ACS so, controlling these risk factors will improve in-hospital outcomes. In STEMI, most patients underwent PPCI, which was reflected in the outcome. In NSTEMI/UA patients, both conservative and invasive management was done, taking into consideration the risk stratification of each patient, making management easier and with a good outcome.
Poly(Alkyl‐Terphenyl Piperidinium) Ionomers and Membranes with an Outstanding Alkaline‐Membrane Fuel‐Cell Performance of 2.58 W cm−2
Authors: Chen Nanjun , Hu Chuan , Wang Ho Hyun , Kim Sun Pyo , Kim Hae Min , Lee Won Hee , Bae Joon Yong , Park Jong Hyeong , Lee Young Moo 
Published: December 2020

AbstractAryl‐ether‐free anion‐exchange ionomers (AEIs) and membranes (AEMs) have become an important benchmark to address the insufficient durability and power‐density issues associated with AEM fuel cells (AEMFCs). Here, we present aliphatic chain‐containing poly(diphenyl‐terphenyl piperidinium) (PDTP) copolymers to reduce the phenyl content and adsorption of AEIs and to increase the mechanical properties of AEMs. Specifically, PDTP AEMs possess excellent mechanical properties (storage modulus>1800 MPa, tensile strength>70 MPa), H2fuel‐barrier properties (<10 Barrer), good ion conductivity, and ex‐situ stability. Meanwhile, PDTP AEIs with low phenyl content and high‐water permeability display excellent peak power densities (PPDs). The present AEMFCs reach outstanding PPDs of 2.58 W cm−2(>7.6 A cm−2current density) and 1.38 W cm−2at 80 °C in H2/O2and H2/air, respectively, along with a specific power (PPD/catalyst loading) over 8 W mg−1, which is the highest record for Pt‐based AEMFCs so far.
Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD‐100/KP1339 in the Endoplasmic Reticulum
Authors: Neuditschko Benjamin , Legin Anton A. , Baier Dina , Schintlmeister Arno , Reipert Siegfried , Wagner Michael , Keppler Bernhard K. , Berger Walter , Meier‐Menches Samuel M. , Gerner Christopher 
Published: December 2020

AbstractThe ruthenium‐based anticancer agent BOLD‐100/KP1339 has shown promising results in several in vitro and in vivo tumour models as well as in early clinical trials. However, its mode of action remains to be fully elucidated. Recent evidence identified stress induction in the endoplasmic reticulum (ER) and concomitant down‐modulation of HSPA5 (GRP78) as key drug effects. By exploiting the naturally formed adduct between BOLD‐100 and human serum albumin as an immobilization strategy, we were able to perform target‐profiling experiments that revealed the ribosomal proteins RPL10, RPL24, and the transcription factor GTF2I as potential interactors of this ruthenium(III) anticancer agent. Integrating these findings with proteomic profiling and transcriptomic experiments supported ribosomal disturbance and concomitant induction of ER stress. The formation of polyribosomes and ER swelling of treated cancer cells revealed by TEM validated this finding. Thus, the direct interaction of BOLD‐100 with ribosomal proteins seems to accompany ER stress‐induction and modulation of GRP78 in cancer cells.
Familiar osteopoikilosis: Case report with differential diagnosis and review of the literature
Authors: Gaudio Agostino , Xourafa Anastasia , Rapisarda Rosario , Gorgone Cristina , Gnoli Maria , Pedrini Elena , Sangiorgi Luca , Catalano Antonino , Zanoli Luca , Mattina Teresa , Castellino Pietro 
Published: December 2020

AbstractOsteopoikilosis (OP) is a rare autosomal dominant sclerosing bone disease, caused by heterozygous mutations in the LEMD3 gene. It is characterised by numerous focal lamellar bone compact deposits in the spongiosa. In this case report, we describe a famliar case of OP and review the literature.
A case of hypervascular tumors in the liver and pancreas: synchronous hepatocellular carcinoma and pancreatic metastasis from renal cell carcinoma 36 years after nephrectomy
Authors: Nakamura Hajime , Tanaka Shingo , Miyanishi Koji , Kawano Yutaka , Osuga Takahiro , Ishikawa Kazuma , Yoshida Makoto , Ohnuma Hiroyuki , Murase Kazuyuki , Takada Kohichi , Yamaguchi Hiroshi , Nagayama Minoru , Kimura Yasutoshi , Takemasa Ichiro , Kato Junji 
Published: December 2020

AbstractIt is sometimes difficult to distinguish between multiple cancers and metastases using only diagnostic imaging, particularly when multiple hypervascular tumors are found in multiple organs. We present a case in which the preoperative histological evaluation was essential to determine the management of a hypervascular pancreatic tumor and liver tumor.
Bulky Polyfluorinated Terphenyldiphenylboranes: Water Tolerant Lewis Acids
Authors: Stoian Corina , Olaru Marian , Cucuiet Teodor A. , Kegyes Krisztina T. , Sava Alexandru , Timoshkin Alexey Y. , Raţ Ciprian I. , Beckmann Jens 
Published: December 2020

AbstractProtocols for the synthesis of the bulky polyfluorinated triarylboranes 2,6‐(C6F5)2C6F3B(C6F5)2 (1), 2,6‐(C6F5)2C6F3B[3,5‐(CF3)2C6H3] (2), 2,4,6‐(C6F5)3C6H2B(C6F5)2 (3), 2,4,6‐(C6F5)3C6H2B[3,5‐(CF3)2C6H3] (4) were developed. All boranes are water tolerant and according to the Gutmann‐Beckett method, 1–3 display Lewis acidities larger than that of the prominent B(C6F5)3.
Colonial bentgrass transcript‐expression differences compared with creeping bentgrass in response to water‐deficit stress
Authors: Amundsen Keenan , Warnke Scott E. , Bushman Bradley S. , Robbins Matthew D. , Martin Ruth , Harris‐Shultz Karen 
Published: December 2020

AbstractNatural stands of creeping bentgrass (Agrostis stolonifera) are often found in wetland areas and exhibit very poor tolerance to dry soils. Colonial bentgrass (A. capillaris) is frequently found in drier habitats and has the ability to go dormant and recover quickly under water‐deficit stress. Hybridization between creeping and colonial bentgrass is possible and a better understanding of gene regulation under water‐deficit conditions of the two species could improve breeding strategies for water deficit–tolerant bentgrasses. A greenhouse dry‐down study was conducted using two creeping bentgrass clones with differing water use profiles and one colonial bentgrass clone. The genotypes were exposed to water‐deficit stress and well‐watered control genotypes were included. Gravimetric evapotranspiration was determined, and control plants watered at 80% ET and deficit irrigation plants watered at 50% ET. Water use rates were similar among all plants with the creeping bentgrass genotypes exhibiting stress earlier and recovering more slowly than the colonial bentgrass. At the conclusion of the experiment, ribonucleic acid sequencing analysis was conducted and there were 975 differentially‐expressed colonial bentgrass transcripts in response to water‐deficit stress compared with an average 98 differentially‐expressed creeping bentgrass transcripts. Among the colonial bentgrass upregulated transcripts in response to water‐deficit stress were eight transcription factors previously shown to be involved in deficit water stress response and several transposon‐related transcripts. This study characterized several transcripts with unique expression changes in colonial bentgrass compared with creeping bentgrass, which may explain why colonial bentgrass is more drought tolerant than creeping bentgrass.
Adult‐like neural representation of species‐specific songs in the auditory forebrain of zebra finch nestlings
Authors: Schroeder Katie M. , Remage‐Healey Luke 
Published: December 2020

AbstractEncoding of conspecific signals during development can reinforce species barriers as well as set the stage for learning and production of species‐typical vocalizations. In altricial songbirds, the development of the auditory system is not complete at hatching, so it is unknown the degree to which recently hatched young can process auditory signals like birdsong. We measured in vivo extracellular responses to song stimuli in a zebra finch (Taeniopygia guttata) secondary auditory forebrain region, the caudomedial nidopallium (NCM). We recorded from three age groups between 13 days post‐hatch and adult to identify possible shifts in stimulus encoding that occur before the opening of the sensitive period of song motor learning. We did not find differences in putative cell type composition, firing rate, response strength, and selectivity across ages. Across ages narrow‐spiking units had higher firing rates, response strength, accuracy, and trial‐by‐trial reliability along with lower selectivity than broad‐spiking units. In addition, we showed that stimulus‐specific adaptation, a characteristic of adult NCM, was also present in nestlings and fledglings. These results indicate that most features of secondary auditory processing are already adult‐like shortly after hatching. Furthermore, we showed that selectivity for species‐specific stimuli is similar across all ages, with the greatest fidelity in temporal coding in response to conspecific song and domesticated Bengalese finch song, and reduced fidelity in response to owl finch song, a more ecologically relevant heterospecific, and white noise. Our study provides the first evidence that the electrophysiological properties of higher‐order auditory neurons are already mature in nestling songbirds.
Population genetic structure and evolution of Batesian mimicry in Papilio polytes from the Ryukyu Islands, Japan, analyzed by genotyping‐by‐sequencing
Authors: Sato Yukuto , Tsurui‐Sato Kaori , Katoh Mitsuho , Kimura Ryosuke , Tatsuta Haruki , Tsuji Kazuki 
Published: December 2020

AbstractBatesian mimicry is a striking example of Darwinian evolution, in which a mimetic species resembles toxic or unpalatable model species, thereby receiving protection from predators. In some species exhibiting Batesian mimicry, nonmimetic individuals coexist as polymorphism in the same population despite the benefits of mimicry. In a previous study, we proposed that the abundance of mimics is limited by that of the models, leading to polymorphic Batesian mimicry in the swallowtail butterfly, Papilio polytes, on the Ryukyu Islands in Japan. We found that their mimic ratios (MRs), which varied among the Islands, were explained by the model abundance of each habitat, rather than isolation by distance or phylogenetic constraint based on the mitochondrial DNA (mtDNA) analysis. In the present study, this possibility was reexamined based on hundreds of nuclear single nucleotide polymorphisms (SNPs) of 93 P. polytes individuals from five Islands of the Ryukyus. We found that the population genetic and phylogenetic structures of P. polytes largely corresponded to the geographic arrangement of the habitat Islands, and the genetic distances among island populations show significant correlation with the geographic distances, which was not evident by the mtDNA‐based analysis. A partial Mantel test controlling for the present SNP‐based genetic distances revealed that the MRs of P. polytes were strongly correlated with the model abundance of each island, implying that negative frequency‐dependent selection interacting with model species shaped and maintained the mimetic polymorphism. Taken together, our results support the possibility that predation pressure, not isolation by distance or other neutral factors, is a major driving force of evolution of the Batesian mimicry in P. polytes from the Ryukyus.
Mathematical analysis of multiple spike time series synchronized in phase with collective theta wave using neural cell model
Authors: Noyama Hiroki , Yoshikai Yuto , Kotani Kiyoshi , Jimbo Yasuhiko 
Published: December 2020

AbstractInformation processing in the brain is performed by the interactions of numerous number of neurons. However, much remains unknown about complex behaviors of a network composed of numerous number of neurons. Especially, in what case cross frequency coupling emerges and how it alters timings of individual firing are open questions. Therefore, in order to quantitatively evaluate the dynamics of the nervous group, we reproduced phenomena such as cross frequency coupling observed in the brain on a mathematical model and analyzed. The analyses of Fokker‐Planck equation provide the region of gamma/theta oscillations as well as their cross‐frequency couplings. In addition, we demonstrated that the populational oscillation synchronizes sequences of spike trains, which is supposed to be a possible mechanism of memory coding in hippocampus by theta‐gamma neural code.
Transverse distribution of cyanobacteria in a regulated urban river
Authors: Yan Huaiyu , Wang Hua , He Xinchen , Liu Yulin , Tang Quanyin , Yang Yeye , Yuan Weihao 
Published: December 2020

AbstractRiver eutrophication and CyanoHABs are severe problems that are often ignored because of high current speed and strong self‐purification. In this paper, Liangxi River, Taihu Basin, was selected as the research area. Combined with field investigation, a 2D water environment mathematical model was developed to simulate the chl‐a distribution in Liangxi River. An indicator (Transverse Distribution Center, TDC) and its normalized form (NTDC) to quantitatively represent material transverse distribution in rivers is proposed and coupled in the model. The calculation showed that TDC and NTDC had the property of random fluctuation, seasonal consistency, and water transfer dependence. The multiple regression equation with normalized data indicated that the maximum offset, average variation rate, and average reverting rate of Liangxi River chl‐a NTDC were most affected by the chl‐a dry matter flux ratio between tributaries and the mainstream, followed by flow and chl‐a concentration ratio. From the perspective of river morphology, for different river width change modes and river bending directions, when water flows into and out of these river sections, the chl‐a transverse distribution is subject to different specific effects. In addition, the position of nutrients and dissolved oxygen significantly affected the position of chl‐a growth when the N/P ratio was not very high. Conversely, a high N/P ratio may contribute to decrease of the chl‐a concentration. Proliferation with abundant nutrients may cause the settlement of chl‐a resulting in a decrease of chl‐a in the water column.
Oscillatory and structural signatures of language plasticity in brain tumor patients: A longitudinal study
Authors: Amoruso Lucia , Geng Shuang , Molinaro Nicola , Timofeeva Polina , Gisbert‐Muñoz Sandra , Gil‐Robles Santiago , Pomposo Iñigo , Quiñones Ileana , Carreiras Manuel 
Published: December 2020

AbstractRecent evidence suggests that damage to the language network triggers its functional reorganization. Yet, the spectro‐temporal fingerprints of this plastic rearrangement and its relation to anatomical changes is less well understood. Here, we combined magnetoencephalographic recordings with a proxy measure of white matter to investigate oscillatory activity supporting language plasticity and its relation to structural reshaping. First, cortical dynamics were acquired in a group of healthy controls during object and action naming. Results showed segregated beta (13–28 Hz) power decreases in left ventral and dorsal pathways, in a time‐window associated to lexico‐semantic processing (~250–500 ms). Six patients with left tumors invading either ventral or dorsal regions performed the same naming task before and 3 months after surgery for tumor resection. When longitudinally comparing patients' responses we found beta compensation mimicking the category‐based segregation showed by controls, with ventral and dorsal damage leading to selective compensation for object and action naming, respectively. At the structural level, all patients showed preoperative changes in white matter tracts possibly linked to plasticity triggered by tumor growth. Furthermore, in some patients, structural changes were also evident after surgery and showed associations with longitudinal changes in beta power lateralization toward the contralesional hemisphere. Overall, our findings support the existence of anatomo‐functional dependencies in language reorganization and highlight the potential role of oscillatory markers in tracking longitudinal plasticity in brain tumor patients. By doing so, they provide valuable information for mapping preoperative and postoperative neural reshaping and plan surgical strategies to preserve language function and patient's quality of life.
Simulation of a set of large‐size thermal enclosures by a substructured reduced‐order model
Authors: Gaume Benjamin , Joly Frédéric , Quéméner Olivier 
Published: December 2020

AbstractIn the context of simulations of coupled thermal enclosures, we present here a substructuring technique adapted to the amalgam reduced‐order modal model (AROMM). This technique consists of splitting the geometry into different zones. A modal model is then applied to each zone, and the coupling of the resulting models is performed via a thermal contact resistance. This technique allows the consideration of physical thermal resistances between different components of the geometry, as well as the making of fictitious cuts within a continuous domain, when its large size causes difficulties in obtaining the global reduced model. Applied to the simulation of a simplified component of a liquefied natural gas carrier, the use of a substructured model with 200 modes allows an access to the whole temperature field with a maximum difference near 1 K and an average difference of the order of 0.2 K, compared with a conventional Lagrange finite‐element model of shell type, which requires 60 times longer calculation.
Nonlinear free convection flow of micropolar nanofluid over a cylinder
Authors: Ibrahim Wubshe , Zemedu Chaluma 
Published: December 2020

AbstractBuoyancy‐determined steady, laminar nonlinear convection flow of micropolar nanofluid with Soret effect, viscous dissipation over a cylinder were evaluated numerically using method bvp4c from matlab software for assorted quantities of leading parameters. Mathematical modeling for the flow problem has been completed with fitting resemblance change and dimensionless variable. A variable similarity solution is offered that bases on various quantities of leading parameters. Influences of these parameters on , are tested and displayed with the charts and graphs. The convergence test has been continued; for quantity of spots larger than suitable mesh number of points. The correctness is unchanged, but it takes time. Also, a comparison with prior study reachable in the literature has been offered with very good conformity is got. The findings show that the existence of Soret number agrees to enhance concentration profile , Wall couple stress coefficient and Nusselt number . But the presence of Eckert Number Ec, allows declining velocity, microrotation, temperature, and concentration profiles.
Abrogating GPT2 in triple‐negative breast cancer inhibits tumor growth and promotes autophagy
Authors: Mitra Devina , Vega‐Rubin‐de‐Celis Silvia , Royla Nadine , Bernhardt Stephan , Wilhelm Heike , Tarade Nooraldeen , Poschet Gernot , Buettner Michael , Binenbaum Ilona , Borgoni Simone , Vetter Martina , Kantelhardt Eva Johanna , Thomssen Christoph , Chatziioannou Aristotelis , Hell Rüdiger , Kempa Stefan , Müller‐Decker Karin , Wiemann Stefan 
Published: December 2020

AbstractUncontrolled proliferation and altered metabolic reprogramming are hallmarks of cancer. Active glycolysis and glutaminolysis are characteristic features of these hallmarks and required for tumorigenesis. A fine balance between cancer metabolism and autophagy is a prerequisite of homeostasis within cancer cells. Here we show that glutamate pyruvate transaminase 2 (GPT2), which serves as a pivot between glycolysis and glutaminolysis, is highly upregulated in aggressive breast cancers, particularly the triple‐negative breast cancer subtype. Abrogation of this enzyme results in decreased tricarboxylic acid cycle intermediates, which promotes the rewiring of glucose carbon atoms and alterations in nutrient levels. Concordantly, loss of GPT2 results in an impairment of mechanistic target of rapamycin complex 1 activity as well as the induction of autophagy. Furthermore, in vivo xenograft studies have shown that autophagy induction correlates with decreased tumor growth and that markers of induced autophagy correlate with low GPT2 levels in patient samples. Taken together, these findings indicate that cancer cells have a close network between metabolic and nutrient sensing pathways necessary to sustain tumorigenesis and that aminotransferase reactions play an important role in maintaining this balance.