bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endovascular treatment of bilateral intracranial vertebral artery aneurysms: an algorithm based on a 10-year neurointerventional experience
Authors: Zhang Yisen , Tian Zhongbin , Zhu Wei , Liu Jian , Wang Yang , Wang Kun , Zhang Ying , Yang Xinjian , Li Wenqiang 
Published: August 2020

Background
The management of bilateral intracranial vertebral artery dissecting aneurysms (IVADAs) is controversial, and requires the development of endovascular treatment modalities and principles. We aim to investigate the endovascular treatment strategy and outcomes of bilateral IVADAs.

Methods
We identified all bilateral IVADAs at a high-volume neurointerventional centre over a 10-year period (from January 2009 to December 2018). Radiographic and clinical data were recorded, and a treatment algorithm was derived.

Results
Twenty-seven patients with bilateral IVADAs (54 IVADAs in total, 51 unruptured, 3 ruptured) were diagnosed. Four patients (14.8%) received single-stage endovascular treatment, 12 patients (44.4%) with staged endovascular treatment and 11 patients (40.8%) with unilateral endovascular treatment of bilateral IVADAs. Thirty-six IVADAs (85.7%) have complete obliteration at the follow-up angiography. Two of three ruptured IVADAs with stent-assisted coiling recanalised, and had further recoiling. Three patients (11.1%) have intraprocedural or postprocedural complications (two in single-stage and one in staged). Twenty-five patients (92.6%) had a favourable clinical outcome, and two patients (7.4%, all in single-stage) showed an unfavourable clinical outcome at follow-up. For the patients with unilateral reconstructive endovascular treatment, the contralateral untreated IVADAs were stable and had no growth or ruptured during follow-up period. None of all IVADAs had rebleeding during the clinical follow-up.

Conclusions
Endovascular treatment can be performed in bilateral IVADAs with high technical success, high complete obliteration rates and acceptable morbidity/mortality. Contralateral IVADAs had low rates of aneurysm growth and haemorrhage when treated in a staged/delayed fashion.
Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of the management of high-risk population
Authors: Wang Yilong , Han Shangrong , Qin Haiqiang , Zheng Huaguang , Jiang Bin , Cao Yong , Gao Yuan , Guan Ling , Jia Qian , Jiang Yong , Jiao Yuming , Li Shuya , Li Yapeng , Li Zixiao , Liu Wei , Ru Xiaojuan , Sun Dongling , Sun Haixin , Wang Penglian , Wang Tingting , Zong Lixia , Guo Lei , Xie Xuewei , Xu Yuming , Xu Yuyuan , Yang Xiaomeng , Yang Yingying , Zhou Mengyuan , Wang Wenzhi 
Published: August 2020

Aim
Cerebrovascular disease is the leading cause of death and disability in China, causing a huge burden among patients and their families. Hence, stroke prevention is critical, especially in the high-risk population. Here, we present the evidence-based guideline suitable for the Chinese population.

Methods
Literature search of PubMed and Cochrane library (from January 1964 to June 2019) was done. After thorough discussion among the writing group members, recommendations were listed and summarised. This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.

Results
This evidence-based guideline was written in three parts: controlling the risk factors of stroke, utilisation of antiplatelet agents and assessing the risks of first-ever stroke. All recommendations were listed along with the recommending classes and levels of evidence.

Conclusions
This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China. Controlling related risk factors, appropriately using antiplatelet agents, assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China.
Modifications to gravitational wave equation from canonical quantum gravity
Authors: Dapor Andrea , Liegener Klaus 
Published: August 2020

AbstractIt is expected that the quantum nature of spacetime leaves its imprint in all semiclassical gravitational systems, at least in certain regimes, including gravitational waves. In this paper we investigate such imprints on gravitational waves within a specific framework: space is assumed to be discrete (in the form of a regular cubic lattice), and this discrete geometry is quantised following Dirac’s canonical quantisation scheme. The semiclassical behavior is then extracted by promoting the expectation value of the Hamiltonian operator on a semiclassical state to an effective Hamiltonian. Considering a family of semiclassical states representing small tensor perturbations to Minkowski background, we derive a quantum-corrected effective wave equation. The deviations from the classical gravitational wave equation are found to be encoded in a modified dispersion relation and controlled by the discreteness parameter of the underlying lattice. For finite discretisations, several interesting effects appear: we investigate the thermodynamical properties of these modified gravitons and, under certain assumptions, derive the tensor power spectrum of the cosmic microwave background. The latter is found to deviate from the classical prediction, in that an amplification of UV modes takes place. We discuss under what circumstances such effect can be in agreement with observations.
The cooperative and competitive mechanisms of a leader’s opinion transmission
Authors: Amirjanov Adil 
Published: August 2020

The paper modeled a leader’s opinion transmission in a population. The proposed model develops the cooperation agent-based continuous model in which the cooperation of individuals is based on the similarity of evolved “tags” which are relative to evolved tag-difference tolerances. In proposed model, an individual’s opinion and the individual’s tolerance are specified as variables in the model. During communication with each other and with a leader, the resources of individuals are incremented, if they are tolerable to the opinions of their opponents. An opinion formation in population is established by a cooperative process — changing individual’s opinion, if the individual is tolerable to the opinions of opponents, and by a competitive process — copying opinions and tolerances of successful individuals who have higher resource. Numerical experiments have proven that the public opinion reached a consensus followed the leader’s opinion.
Late Silurian zircon U–Pb ages from the Ludlow and Downton bone beds, Welsh Basin, UK
Authors: Catlos Elizabeth J. , Mark Darren F. , Suarez Stephanie , Brookfield Michael E. , Miller C. Giles , Schmitt Axel K. , Gallagher Vincent , Kelly Anne 
Published: August 2020

The Ludlow Bone Bed (Welsh Basin) is a critical stratigraphic horizon and contains a rich assemblage of fish scales. Units above provide insights into the early evolution of animal and plant life. The bed has not yet been radioisotopically dated. Here, we report 207 secondary ion mass spectrometry (SIMS) ages from 102 zircon (ZrSiO
4
) grains from the Ludlow (
n
= 2) and stratigraphically higher Downton (
n
= 1) bone beds. SIMS ages are middle Ordovician (471.6 ± 20.7 Ma) to late Devonian (375.7 ± 14.6 Ma,
238
U–
206
Pb, ±1σ analytical uncertainty). Cathodoluminescence images show that the youngest ages appear affected by alteration. Chemical abrasion isotope dilution thermal ionization mass spectrometry (CA-ID-TIMS) U–Pb geochronology was utilized to improve precision. Detrital zircon grains from Downton yield 424.91 ± 0.34/0.42/0.63 Ma and from Ludlow 424.85 ± 0.32/0.41/0.62 Ma (
n
= 5 each,
238
U–
206
Pb, ±2σ analytical, tracer or systematic uncertainty). These ages provide a maximum deposition age. Results overlap the basal Přídolí age (423.0 ± 2.3 Ma) in its stratotype (Požáry Section, Reporyje, Prague, Czech Republic). The Ludlow Bone Bed marks the base of the local Downton Group, which has previously been correlated with the base of the Přídolí Series. The CA-ID-TIMS ages are older than those for other land arthropod-bearing sediments, such as the Cowie Harbour Fish Bed and Rhynie Chert.

Supplementary material:
An Excel file containing detailed information on the SIMS analyses, a figure showing calibration curves for AS3 standards sputtered over sessions 1 and 2, and a figure showing CA-ID-TIMS U–Pb age data (concordia and weighted mean plots) are available at
https://doi.org/10.6084/m9.figshare.c.5087031
Long-Term Follow-Up Study on the Uptake of Genetic Counseling and Predictive DNA Testing in Inherited Cardiac Conditions
Authors: van den Heuvel Lieke M. , van Teijlingen Maxiem O. , van der Roest Wilma , van Langen Irene M. , Smets Ellen M.A. , van Tintelen J. Peter , Christiaans Imke 
Published: August 2020

Background:
Inherited cardiac conditions present with a wide range of symptoms and may even result in sudden cardiac death. Relatives of probands with a confirmed pathogenic genetic variant are advised predictive DNA testing to enable prevention and treatment. In 2 previous cohort studies of 115 probands with a pathogenic variant, family uptake of genetic counseling was assessed in the first year(s) after test result disclosure to the proband. This study assesses uptake in these cohorts in the 14 to 23 years following disclosure.

Methods:
Uptake was determined retrospectively using patient records. First-degree relatives, and second-degree relatives of a deceased first-degree relative suspected of having an inherited cardiac condition, were considered eligible.

Results:
Of 717 eligible relatives (598 first-degree and 119 second-degree relatives), 60% attended genetic counseling. Most of them (68.6%) attended genetic counseling in the first year. A total of 98.4% of counseled relatives pursued predictive DNA testing. A total of 49.2% was identified as carrier. Median time between disclosure to the proband and counseling of relatives was 6 months (range: 0–187 months). Attending genetic counseling was observed more frequently in first-degree relatives, female relatives, primary arrhythmia syndromes, relatives with manifest inherited cardiac condition, relatives without children and families with sudden cardiac death in first-degree relatives <40 years.

Conclusions:
During median follow-up of 16 years, 60.0% of relatives attended genetic counseling, with 41.0% in the first year. Our results may suggest that some relatives are not or inadequately informed or that barriers against genetic counseling are present. Further research is needed into interventions facilitating family communication, increasing awareness among families and healthcare professionals, and lowering thresholds for genetic counseling.
ST-Segment–Elevation Myocardial Infarction During COVID-19 Pandemic
Authors: Gramegna Mario , Baldetti Luca , Beneduce Alessandro , Pannone Luigi , Falasconi Giulio , Calvo Francesco , Pazzanese Vittorio , Sacchi Stefania , Pagnesi Matteo , Moroni Francesco , Ajello Silvia , Melisurgo Giulio , Agricola Eustachio , Camici Paolo G. , Scandroglio Anna Mara , Landoni Giovanni , Ciceri Fabio , Zangrillo Alberto , Cappelletti Alberto Maria 
Published: August 2020

Background:
Coronavirus disease 2019 (COVID-19) pandemic has led to a fast and radical transformation in social, economic, and healthcare networks. COVID-19 outbreak may thus have profound indirect consequences on clinical presentation and management of patients with ST-segment–elevation myocardial infarction (STEMI). Aim of this study was to assess clinical features of patients with STEMI during COVID-19 pandemic.

Methods:
This single-center, prospective study from a regional public service healthcare hub in Milan included all consecutive patients with STEMI admitted to our institute from February 21 to April 1, 2020 (during COVID-19 pandemic). These patients were compared with a historical cohort of patients admitted for STEMI during the analogous time period (February 21 to April 1) in 2018 and 2019, in terms of time from symptoms onset to hospital admission, clinical characteristics, and in-hospital outcomes.

Results:

A total of 26 patients were admitted for STEMI during the study period, and 7 (26.9%) of these patients tested positive for severe acute respiratory syndrome coronavirus 2. On admission, medical therapy, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers use, was similar between cohorts. Median (interquartile range) time from symptoms onset to hospital admission was significantly longer in 2020 as compared to the historical cohort (15.0 [2.0–48.0] versus 2.0 [1.0–3.0] hours;
P
<0.01). A higher proportion of patients presenting with late presentation STEMI was observed in 2020 compared with the historical cohort (50.0% versus 4.8%;
P
<0.01). Primary percutaneous coronary intervention resulted indicated in 80.8% of patients in 2020 compared with 100% in the historical cohort (
P
=0.06). In-hospital death, thromboembolism, mechanical ventilation, or hemodynamic decompensation needing inotropic or mechanical support were similar between years.

Conclusions:
These preliminary results from a cardiovascular regional public service healthcare hub demonstrate a significantly longer time from symptoms onset to hospital admission among patients with STEMI during COVID-19 pandemic compared with the same time period in the previous 2 years.
No Evidence for Erythro-Myeloid Progenitor-Derived Vascular Endothelial Cells in Multiple Organs
Authors: Feng Teng , Gao Zibei , Kou Shan , Huang Xinyan , Jiang Zhen , Lu Zhengkai , Meng Jufeng , Lin Chao-Po , Zhang Hui 
Published: August 2020

Rationale:
Endothelial cells are thought to emerge de novo from the mesoderm to form the entire circulatory system. Recently, erythro-myeloid progenitors (EMPs) have been proposed to be another remarkable developmental origin for blood vessels in multiple organs, including the hindbrain, liver, lung, and heart, as demonstrated by lineage tracing studies using different genetic tools. These observations challenge the current consensus that intraembryonic vessels are thought to expand solely by the proliferation of preexisting endothelial cells. Resolution of this controversy over the developmental origin of endothelial cells is crucial for developing future therapeutics for vessel-dependent organ repair and regeneration.

Objective:
To examine the contribution of EMPs to intraembryonic endothelial cells.

Methods and Results:

We first used a transgenic mouse expressing a tamoxifen-inducible Mer-iCre fusion protein driven by the Csf1r (colony stimulating factor 1 receptor) promoter. Genetic lineage tracing based on Csf1r-Mer-iCre-Mer showed no contribution of EMPs to brain endothelial cells identified by several markers. We also generated a knock-in mouse line by inserting an internal ribosome entry site-iCre cassette into the 3′ untranslated region of
Csf1r
gene to further investigate the cellular fates of EMPs. Similarly, we did not find any Csf1r-ires-iCre traced endothelial cells in brain, liver, lung, or heart in development either. Additionally, we found that Kit (KIT proto-oncogene receptor tyrosine kinase) was expressed not only in EMPs but also in embryonic hindbrain endothelial cells. Therefore, Kit promoter–driven recombinase, such as Kit-CreER, is a flawed tool for lineage tracing when examining the contribution of EMPs to hindbrain endothelial cells. We also traced CD45 (protein tyrosine phosphatase receptor type C; Ptprc)
+
circulating EMPs and did not find any CD45 lineage-derived endothelial cells during development.

Conclusions:
Our study suggested that EMPs are not the origin of intraembryonic endothelial cells.
Seasonal Modulation of Trapped Gravity Waves and Their Imprints on Trade Wind Clouds
Authors: Stephan Claudia Christine 
Published: August 2020

Abstract
Shallow convection over the oceans is responsible for the largest uncertainties in climate projections. Idealized simulations have shown decades ago that shallow clouds generate internal gravity waves, which under certain atmospheric background conditions become trapped inside the troposphere and influence the development of clouds. These feedbacks, which occur at horizontal scales of up to several tens of kilometers. are neither resolved nor parameterized in traditional global climate models (GCMs), while the newest generation of GCMs (grid spacings &lt; 5 km) is starting to resolve them. The interactions between the convective boundary layer and trapped waves have almost exclusively been studied in highly idealized frameworks and it remains unclear to what degree this coupling affects the organization of clouds in the real atmosphere or in the new generation of GCMs. Here, the coupling between clouds and trapped waves is examined in 2.5-km simulations that span the entirety of the tropical Atlantic and are initialized and forced with meteorological analyses. The coupling between clouds and trapped waves is sufficiently strong to be detected in these simulations of full complexity. Stronger upper-tropospheric westerly winds are associated with a stronger cloud–wave coupling. In the simulations this results in a highly organized scattered cloud field with cloud spacings of about 19 km, matching the dominant trapped wavelength. Based on the large-scale atmospheric state, wave theory can reliably predict the regions and times where cloud–wave feedbacks become relevant to convective organization. Theory, the simulations, and satellite imagery imply a seasonal cycle in the trapping of gravity waves.
Sensitivity of MCS Low-Frequency Gravity Waves to Microphysical Variations
Authors: Adams-Selin Rebecca D. 
Published: August 2020

AbstractThe sensitivity of low-frequency gravity waves generated during the development and mature stages of an MCS to variations in the characteristics of the rimed ice parameterization were tested through idealized numerical simulations over a range of environment shears and instabilities. Latent cooling in the simulations with less dense, graupel-like rimed ice was more concentrated aloft near the melting level, while cooling in simulations with denser, hail-like rimed ice extended from the melting level to the surface. However, the cooling profiles still had significant internal variability across different environments and over each simulation’s duration. Initial wave production during the MCS developing stage was fairly similar in the hail and graupel simulations. During the mature stages, graupel simulations showed stronger perturbations in CAPE due to the cooling and associated wave vertical motion being farther aloft; hail simulations showed stronger perturbations in LFC due to cooling and wave vertical motion being concentrated at lower levels. The differences in the cooling profiles were not uniform enough to produce consistently different higher-order wave modes. However, the initiation of discrete cells ahead of the convective line was found to be highly sensitive to the nature of the prior destabilizing wave. Individual events of discrete propagation were suppressed in some of the graupel simulations due to the higher location of both peak cooling and vertical wave motion. Such results underscore the need to fully characterize MCS microphysical heating profiles and their low-frequency gravity waves to understand their structure and development.
Long-Term Statistics of Riming in Nonconvective Clouds Derived from Ground-Based Doppler Cloud Radar Observations
Authors: Kneifel Stefan , Moisseev Dmitri 
Published: August 2020

AbstractRiming is an efficient process of converting liquid cloud water into ice and plays an important role in the formation of precipitation in cold clouds. Due to the rapid increase in ice particle mass, riming enhances the particle’s terminal velocity, which can be detected by ground-based vertically pointing cloud radars if the effect of vertical air motions can be sufficiently mitigated. In our study, we first revisit a previously published approach to relate the radar mean Doppler velocity (MDV) to rime mass fraction (FR) using a large ground-based in situ dataset. This relation is then applied to multiyear datasets of cloud radar observations collected at four European sites covering polluted central European, clean maritime, and Arctic climatic conditions. We find that riming occurs in 1%–8% of the nonconvective ice containing clouds with median FR between 0.5 and 0.6. Both the frequency of riming and FR reveal relatively small variations for different seasons. In contrast to previous studies, which suggested enhanced riming for clean environments, our statistics indicate the opposite; however, the differences between the locations are overall small. We find a very strong relation between the frequency of riming and temperature. While riming is rare at temperatures lower than −12°C, it strongly increases toward 0°C. Previous studies found a very similar temperature dependence for the amount and droplet size of supercooled liquid water, which might be closely connected to the riming signature found in this study. In contrast to riming frequency, we find almost no temperature dependence for FR.
Decadal Variability of the Anticyclone in the Western North Pacific
Authors: Xie Mingmei , Wang Chunzai 
Published: August 2020

AbstractThe western North Pacific anomalous anticyclone (WNPAC) significantly affects East Asian climate. Previous studies have elucidated interannual variability of the WNPAC associated with El Niño, but decadal variability of the WNPAC remains unknown. The present paper investigates the dominant modes of decadal variability of the WNPAC by using observational data. The first decadal mode, characterized by an anomalous anticyclone centered over the western North Pacific, is associated with the Pacific decadal oscillation (PDO). The relationship between the first mode and the PDO shifted from in phase to out of phase around 1966. From 1900 to 1966 when the PDO and the first mode are in phase, the anticyclone is maintained by the effects of both the strengthened Aleutian low through meridional atmospheric forcing and Indian Ocean warming through enhanced zonal Walker circulation. From 1967 to 2012, the anticyclone is induced by cold SST anomalies over the central equatorial Pacific when the PDO and the first mode are out of phase. The second decadal mode is characterized by an anomalous anticyclone extending from southeastern China to the Philippine Sea and is associated with the Maritime Continent (MC). This anticyclone resides in the sinking branch of the local Hadley circulation, triggered by enhanced convection associated with the MC warming from 1900 to 2012. The finding of the decadal WNPAC in this paper may provide a new way to explain East Asian climate on a decadal time scale.