bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYOCARDIAL INFARCTION AT YOUNG ADULTS – RISK FACTORS AND MANAGEMENT
Authors: Hristova Irinka , Georgieva Despina , Trifonov Krasimir , Belkolev Ivo , Danov Vladimir 
Published: November 2020

Introduction: Generally, the myocardial infarction is far more common among the population which is over 45 years. However, on rare occasion it can be seen amongst the younger population such as the above discussed case.
Objective: The report from the case of this overview shows an acute myocardial infarction in a young 28-year-old man, due to thrombotic occlusion that has nothing to do with coagulation problems.
Methods: The Coronary Angiography is of paramount importance when it comes to reaching a correct diagnosis, and by extension, treatments for such cases. Moreover, the detailed clinical case history further aided in determining the key risk factors.
Results: When it ensues in younger age, the myocardial infarction is associated with significant morbidity, psychological effects and financial limits to the individual and his or her family.
Conclusions: In the examined case we described the contemporary management of a myocardial infraction event, wherein the patient was advised to stop smoking, form a consistent regular exercising physical activity regime, put more conscious effort into having a healthy diet, and reduce stress levels as much as possible.
CAREER ATTITUDES OF STUDENTS IN THE PROCESS OF TRANSITION TO UPPER SECONDARY EDUCATION
Authors: Aleksandrova Desislava , Iskrev Dimitar 
Published: November 2020

The behavioural dimensions of students' career choices in the process of transition to upper secondary education are of particular pedagogical interest. Studying career attitudes will not only contribute to outlining the status, completeness and effective use of personal pathsbut will also provide efficient means by which the future professional career will be pursued.
The conducted original study included 64 seventh-grade students from educational institutions, typical for the Bulgarian education system. The behavioural dimensions of a career choice, i.e. Planning and exploration, were studied using a self-evaluation rating scale. It included a series of questions for the respondent, to self-report on the degree of expression of the relevant aspect of their career choice.
The actual expression of career attitudes in seventh-graders is determined by a small number of internal factors (in most cases two) of well-defined nature for each career development component. For the planning part, they are related to specifying the perceptions of career goals and their temporal boundaries. For the exploration part, the factors reflect the nature of the information source, i.e. informal or institutionalized.
The study of the behavioural dimensions of career development forms a basis for conclusions on students' readiness to make informed career choices and their needs in this regard. In this way, the place and role of the school as a socializing institution in the process of personal development are outlined.
THE DEVELOPMENT OF A CULTURE OF CHILDREN’S BEHAVIOUR IN PRESCHOOL EDUCATION INSTITUTIONS: ANALYSIS OF PRESCHOOL TEACHERS’ EXPERIENCE
Authors: Smilgienė Jurgita , Masiliauskienė Erika , Lenkauskaitė Jurgita 
Published: November 2020

The Lithuanian society lives in the period of changes in which personal values are influenced by our surroundings. The decline of a culture of behaviour is observed in society and it is increasingly evident in children’s and youth’s behaviour. Children lose their autonomy, respect for the individual and nation. There is increasingly visible rude communication, social environmental intolerance and this just proves that our younger generation has little culture of behaviour. The earlier you introduce children to the basic conduct of cultural values and their aspirations to develop, the better results will be achieved in the correct behaviour modelling for life in society. For this reason, not only the family, but also preschool, i.e., educators, are responsible for the cultured behaviour of children, education and promotion to be polite, respectful, honest, friendly, etc.
The object of the research – the development of a culture of behaviour of preschool age children. The aim – to reveal how a culture of children’s behaviour is developed in preschool.
A study was conducted in preschool institutions of Northern Lithuania. In this case a qualitative research strategy was chosen. The methods of the research: analysis and synthesis of the sources of scientific literature and open-ended written survey of preschool educators. Teachers from 23 preschool institutions participated in the research. Qualitative research data were processed using the method of content analysis. The research revealed what concept the respondents give to the definition of a culture of children’s behaviour and what methods they apply in their daily work. The concept of a culture of behaviour from the point of view of teachers is: culture of activity, of communication, of hygiene and nurturing nature. Preschool educators develop a culture of behaviour using traditional methods such as games, conversations, reading, literary and cartoon analysis in their professional activities.
THE EMOTIONAL-MOTIVATIONAL COMPONENT OF SCHOOL READINESS OF BEGINNING PUPILS
Authors: Teleková Radka , Marcineková Tatiana 
Published: November 2020

A child's wish to become a pupil is one of the important identifiers of his / her school readiness. Its assessment at the beginning of schooling provides a picture of the child's initial ability at the beginning of the first year of study in primary school. The focus of this article is the motivational component of school readiness, which has an impact on the individual form of adaptation of beginning pupils. The subject of the research was to find out the presence of individual motives in the structure of the emotional-motivational component of school readiness of children at the beginning of school attendance. The defined component consists of social, cognitive and moral motives, which are interconnected. We were used a questionnaire with ten items in the research activity. The respondents were pupils of the first year of study in selected elementary schools. The results showed that the social, cognitive and moral motive were presented within the emotional-motivational component of school readiness. Overall, there were positive answers to the three motives, which showed a high level of motivation in the research sample. The level of the emotional-motivational component of becoming a pupil is one of the elements ensuring the successful adaptation of the pupil at the beginning of school life. Strengthening the incentive to become a pupil, deepening the desire to learn new things and shaping social skills for existence in the classroom are seen as a tool for developing the motivational sphere of school readiness.
Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy
Authors: Buffault Juliette , Zéboulon Pierre , Liang Hong , Chiche Anthony , Luzu Jade , Robin Mathieu , Rabut Ghislaine , Labetoulle Marc , Labbé Antoine , Baudouin Christophe 
Published: November 2020

Purpose
To investigate the corneal epithelial thickness topography with optical coherence tomography (OCT) and its relationship with vision quality in epithelial basement membrane dystrophy (EBMD).

Methods
45 eyes of EBMD patients, 26 eyes of dry eye (DED) patients and 22 eyes of normal subjects were enrolled. All participants were subjected to 9-mm corneal epithelial mapping with OCT and vision quality was assessed with the optical quality analysis system using the objective scatter index (OSI). Central, superior, inferior, minimum, maximum, and standard deviation of epithelium thickness (Irregularity), were analysed and correlations with the OSI were calculated.

Results
The mean (±SD) central, inferior and maximum epithelial thicknesses of the EBMD patients (respectively, 56.4 (±8.1) μm, 58.9 (±6.4) μm, and 67.1 (±8.3) μm) were thicker compared to DED patients (P<0.05) and normal subjects (P<0.05). We found greater irregularity of epithelial thickness in EBMD (5.1±2.5 μm) compared to DED patients (2.6±1.0 μm) (P = 4.4.10−6) and normal subjects (2.1±0.7 μm) (P = 7.6.10−7). The mean OSI was worse in EBMD patients than in DED patients (P = 0.01) and compared to normal subjects (P = 0.02). The OSI correlated with the epithelial thickness irregularity (Spearman coefficient = 0.54; P = 2.65.10−5).

Conclusions
The OCT pachymetry map demonstrated that EBMD patients had thicker corneal epithelium in the central and inferior region. These changes were correlated with objective measurements of vision quality. This OCT characterisation of the EMBD provides a better understanding of the epithelial behaviour in this dystrophy and its role in vision quality.
Correlation of genetic alterations by whole-exome sequencing with clinical outcomes of glioblastoma patients from the Lebanese population
Authors: Saadeh Fadi S. , Morsi Rami Z. , El-Kurdi Abdallah , Nemer Georges , Mahfouz Rami , Charafeddine Maya , Khoury Jessica , Najjar Marwan W. , Khoueiry Pierre , Assi Hazem I. 
Published: November 2020

Introduction
Glioblastoma (GBM) is an aggressive brain tumor associated with high degree of resistance to treatment. Given its heterogeneity, it is important to understand the molecular landscape of this tumor for the development of more effective therapies. Because of the different genetic profiles of patients with GBM, we sought to identify genetic variants in Lebanese patients with GBM (LEB-GBM) and compare our findings to those in the Cancer Genome Atlas (TCGA).

Methods
We performed whole exome sequencing (WES) to identify somatic variants in a cohort of 60 patient-derived GBM samples. We focused our analysis on 50 commonly mutated GBM candidate genes and compared mutation signatures between our population and publicly available GBM data from TCGA. We also cross-tabulated biological covariates to assess for associations with overall survival, time to recurrence and follow-up duration.

Results
We included 60 patient-derived GBM samples from 37 males and 23 females, with age ranging from 3 to 80 years (mean and median age at diagnosis were 51 and 56, respectively). Recurrent tumor formation was present in 94.8% of patients (n = 55/58). After filtering, we identified 360 somatic variants from 60 GBM patient samples. After filtering, we identified 360 somatic variants from 60 GBM patient samples. Most frequently mutated genes in our samples included ATRX, PCDHX11, PTEN, TP53, NF1, EGFR, PIK3CA, and SCN9A. Mutations in NLRP5 were associated with decreased overall survival among the Lebanese GBM cohort (p = 0.002). Mutations in NLRP5 were associated with decreased overall survival among the Lebanese GBM cohort (p = 0.002). EGFR and NF1 mutations were associated with the frontal lobe and temporal lobe in our LEB-GBM cohort, respectively.

Conclusions
Our WES analysis confirmed the similarity in mutation signature of the LEB-GBM population with TCGA cohorts. It showed that 1 out of the 50 commonly GBM candidate gene mutations is associated with decreased overall survival among the Lebanese cohort. This study also highlights the need for studies with larger sample sizes to inform clinicians for better prognostication and management of Lebanese patients with GBM.
Artificial intelligence to predict the BRAFV600E mutation in patients with thyroid cancer
Authors: Yoon Jiyoung , Lee Eunjung , Koo Ja Seung , Yoon Jung Hyun , Nam Kee-Hyun , Lee Jandee , Jo Young Suk , Moon Hee Jung , Park Vivian Youngjean , Kwak Jin Young 
Published: November 2020

PurposeTo investigate whether a computer-aided diagnosis (CAD) program developed using the deep learning convolutional neural network (CNN) on neck US images can predict the BRAFV600Emutation in thyroid cancer.Methods469 thyroid cancers in 469 patients were included in this retrospective study. A CAD program recently developed using the deep CNN provided risks of malignancy (0–100%) as well as binary results (cancer or not). Using the CAD program, we calculated the risk of malignancy based on a US image of each thyroid nodule (CAD value). Univariate and multivariate logistic regression analyses were performed including patient demographics, the American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TIRADS) categories and risks of malignancy calculated through CAD to identify independent predictive factors for the BRAFV600Emutation in thyroid cancer. The predictive power of the CAD value and final multivariable model for the BRAFV600Emutation in thyroid cancer were measured using the area under the receiver operating characteristic (ROC) curves.ResultsIn this study, 380 (81%) patients were positive and 89 (19%) patients were negative for the BRAFV600Emutation. On multivariate analysis, older age (OR = 1.025, p = 0.018), smaller size (OR = 0.963, p = 0.006), and higher CAD value (OR = 1.016, p = 0.004) were significantly associated with the BRAFV600Emutation. The CAD value yielded an AUC of 0.646 (95% CI: 0.576, 0.716) for predicting the BRAFV600Emutation, while the multivariable model yielded an AUC of 0.706 (95% CI: 0.576, 0.716). The multivariable model showed significantly better performance than the CAD value alone (p = 0.004).ConclusionDeep learning-based CAD for thyroid US can help us predict the BRAFV600Emutation in thyroid cancer. More multi-center studies with more cases are needed to further validate our study results.
Rural and Remote Continuing Nursing Education: An Integrative Literature Review
Authors: Pavloff Michelle , Farthing Pamela M. , Duff Elsie 
Published: November 2020

Background: Rural and remote nursing has unique practice requirements that create a need for distinct education and practice preparation. Preparing registered nurses (RNs) to work in rural and remote communities is essential for the support and advancement of rural and remote health, as there is a shortage of rural and remote health care providers. Purpose: An integrative literature review was conducted to identify the current continuing education needs of rural and remote RNs internationally. Sample: Eight studies were included in the integrative review of the literature. Countries reported in the literature included Canada (n = 2), Australia (n = 2), Sweden (n = 1) and the United States (n = 3). Method: An integrative literature review on rural and remote nursing practice continuing education was conducted using Torraco’s (2005) guidelines, in addition to Whittemore and Knafl’s (2005) methodological strategies. A search strategy was created, tested, and approved by the research team.Themes were extracted, collated, analyzed, and knowledge synthesized. Findings: Rural and remote RNs identified areas requiring enhanced ongoing training. The identified training areas were summarized into the following four themes: 1) Comprehensive specialized nursing practice for direct patient care, 2) Unanticipated events, 3) Non-direct patient care, and 4) Advanced specialty courses. Conclusion: The autonomy, competency, and expertise that is expected of RNs working in rural and remote locations requires educational supports. Rural and remote nursing continuing education is required in the areas of: comprehensive specialized nursing practice for direct patient care, unanticipated events, non-direct patient care, and advanced specialty courses. Keywords: continuing education, integrative review, registered nurse(s), remote, rural Acknowledgements: The authors thank Saskatchewan Polytechnic for partial funding of this review through the Seed Applied Research Program. The authors also thank their research team member Chau Ha and research assistant Devendrakumar Kanani for their contributions to this integrative review.
Pembuatan Bioetanol dari Pati Umbi Uwi (Discorea alata) melalui Proses Fermentasi dan Distilasi
Authors: Hargono Hargono 
Published: November 2020

Bioetanol adalah nama lain etanol yang dapat dibuat dari bahan baku biomasa. Tanaman Uwi (Discorea alata) mudah tumbuh di lereng-lereng gunung, hutan sebagai tanaman liar, namun tanaman ini ada yang sengaja ditanam orang. Tanaman Uwi mengandung karbohidrat cukup tinggi (32,64%) sehingga dapat dimanfaatkan sebagai bahan baku pembuatan bioetanol. Pada penelitian ini umbi Uwi terlebih dulu dibuat pati agar memudahkan terjadinya proses hidrolisis dan fermentasi. Proses pembuatan pati Uwi adalah dengan mengekstrak bubur (hasil parutan) Uwi menggunakan air. Proses hidrolisis dan fermentasi dilakukan secara serentak atau Simultaneous Saccharification and Fermentation (SSF). Konsentrasi pati Uwi 200 g/L, konsentrasi enzim (Stargen TM 002) 1,5% (w/w), konsentrasi yeast 1,10% (w/w) dan pada suhu 30°C. Hasil proses SSF adalah konsentrasi bioetanol kadar rendah, sehingga agar kemurnian bioetanol meningkat perlu dilakukan distilasi. Proses distilasi menggunakan distilasi 2 tahap, terdiri dari 2 kolom, meliputi kolom 1 tanpa bahan isian dilengkapi pipa pendingin yang berbentuk spiral, sedangkan kolom 2 berisi bahan isian yaitu packing. Proses distilasi 2 tahap masing-masing ini dioperasikan pada suhu 78°C. Tujuan penelitian ini adalah mempelajari pengaruh waktu SSF terhadap konsentrasi bioetanol dan mempelajari waktu distilasi tahap 1 dan 2 terhadap konsentrasi bioetanol. Proses SSF dilakukan selama 90 jam. Hasil terbaik proses SSF dicapai selama 72 jam yang menghasilkan konsentrasi bioetanol 12,30%. Proses distilasi 1 dan 2 dilakukan masing-masing selama 105 menit. Hasil terbaik dari distilasi tahap 1 dan tahap 2dicapai selama waktu masing-masing 90 menit, yaitu konsentrasi bioetanol 27,93% dan 85,30%. Perancangan alat distilasi 2 tahap ini layak digunakan sebagai alat pemunian bioetanol hasil SSF.
Permutable compiled queries
Authors: Menon Prashanth , Ngom Amadou , Ma Lin , Mowry Todd C. , Pavlo Andrew 
Published: November 2020

Just-in-time (JIT) query compilation is a technique to improve analytical query performance in database management systems (DBMSs). But the cost of compiling each query can be significant relative to its execution time. This overhead prohibits the DBMS from employing well-known adaptive query processing (AQP) methods to generate a new plan for a query if data distributions do not match the optimizer's estimations. The optimizer could eagerly generate multiple sub-plans for a query, but it can only include a few alternatives as each addition increases the compilation time.
We present a method, called Permutable Compiled Queries (PCQ), that bridges the gap between JIT compilation and AQP. It allows the DBMS to modify compiled queries without needing to recompile or including all possible variations before the query starts. With PCQ, the DBMS structures a query's code with indirection layers that enable the DBMS to change the plan even while it is running. We implement PCQ in an in-memory DBMS and compare it against non-adaptive plans in a microbenchmark and against state-of-the-art analytic DBMSs. Our evaluation shows that PCQ outperforms static plans by more than 4X and yields better performance on an analytical benchmark by more than 2X against other DBMSs.
The Spinal Control of Backward Locomotion
Authors: Harnie Jonathan , Audet Johannie , Klishko Alexander N. , Doelman Adam , Prilutsky Boris I. , Frigon Alain 
Published: November 2020

Animal locomotion requires changing direction, from forward to backward. Here, we tested the hypothesis that sensorimotor circuits within the spinal cord generate backward locomotion and adjust it to task demands. We collected kinematic and electromyography (EMG) data during forward and backward locomotion at different treadmill speeds before and after complete spinal transection in six adult cats (three males and three females). After spinal transection, five/six cats performed backward locomotion, which required tonic somatosensory input in the form of perineal stimulation. One spinal cat performed forward locomotion but not backward locomotion while two others stepped backward but not forward. Spatiotemporal adjustments to increasing speed were similar in intact and spinal cats during backward locomotion and strategies were similar to forward locomotion, with shorter cycle and stance durations and longer stride lengths. Patterns of muscle activations, including muscle synergies, were similar for forward and backward locomotion in spinal cats. Indeed, we identified five muscle synergies that were similar during forward and backward locomotion. Lastly, spinal cats also stepped backward on a split-belt treadmill, with the left and right hindlimbs stepping at different speeds. Therefore, our results show that spinal sensorimotor circuits generate backward locomotion but require additional excitability compared with forward locomotion. Similar strategies for speed modulation and similar patterns of muscle activations and muscle synergies during forward and backward locomotion are consistent with a shared spinal locomotor network, with sensory feedback from the limbs controlling the direction.SIGNIFICANCE STATEMENTAnimal locomotion requires changing direction, including forward, sideways and backward. This paper shows that the center controlling locomotion within the spinal cord can produce a backward pattern when instructed by sensory signals from the limbs. However, the spinal locomotor network requires greater excitability to produce backward locomotion compared with forward locomotion. The paper also shows that the spinal network controlling locomotion in the forward direction also controls locomotion in the backward direction.