bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epilepsy in LAMA2‐related muscular dystrophy: An electro‐clinico‐radiological characterization
Authors: Natera‐de Benito Daniel , Muchart Jordi , Itzep Debora , Ortez Carlos , González‐Quereda Lidia , Gallano Pía , Ramirez Alia , Aparicio Javier , Domínguez‐Carral Jana , Carrera‐García Laura , Expósito‐Escudero Jessica , Pardo Cardozo Nathalia , Cuadras Daniel , Codina Anna , Jou Cristina , Jimenez‐Mallebrera Cecilia , Palau Francesc , Colomer Jaume , Arzimanoglou Alexis , Nascimento Andrés , San Antonio‐Arce Victoria 
Published: April 2020

AbstractObjectiveTo delineate the epileptic phenotype of LAMA2‐related muscular dystrophy (MD) and correlate it with the neuroradiological and muscle biopsy findings, as well as the functional motor phenotype.MethodsClinical, electrophysiological, neuroradiological, and histopathological data of 25 patients with diagnosis of LAMA2‐related MD were analyzed.ResultsEpilepsy occurred in 36% of patients with LAMA2‐related MD. Mean age at first seizure was 8 years. The most common presenting seizure type was focal‐onset seizures with or without impaired awareness. Visual aura and autonomic signs, including vomiting, were frequently reported. Despite a certain degree of variability, bilateral occipital or temporo‐occipital epileptiform abnormalities were by far the most commonly observed. Refractory epilepsy was found in 75% of these patients. Epilepsy in LAMA2‐related MD was significantly more prevalent in those patients in whom the cortical malformations were more extensive. In contrast, the occurrence of epilepsy was not found to be associated with the patients' motor ability, the size of their white matter abnormalities, or the amount of residual merosin expressed on muscle.SignificanceThe epileptic phenotype of LAMA2‐related MD is characterized by focal seizures with prominent visual and autonomic features associated with EEG abnormalities that predominate in the posterior quadrants. A consistent correlation between epileptic phenotype and neuroimaging was identified, suggesting that the extension of the polymicrogyria may serve as a predictor of epilepsy occurrence.
OTTOKAR DOMMA: A SATIRIST, BUT FOR OR AGAINST GDR SOCIALISM?
Authors: Frank Mary 
Published: April 2020

AbstractOttokar Domma was regarded as a children's author during the lifetime of the GDR, and continues to be seen as such today. This article argues that, while Domma's stories about the mischievous schoolboy Ottokar did appeal to GDR children, they should also be acknowledged as satirical. It further argues that this satire can be read in two ways, as regime‐supporting or regime‐critical. It first re‐locates the stories in their original context of publication in a regime‐supporting satirical magazine and shows that Ottokar's use of language, in particular, served the officially defined purposes of satire by alerting adult readers to their careless misunderstandings of socialism's priorities. It then interrogates Domma's self‐portrayal, the use of parallel literary forms for satirical purposes, and the stories’ themes to argue that the stories can alternatively, or additionally, be read as regime‐critical satire. It proposes that Domma was a far more ambiguous and multi‐faceted figure in the GDR literary and satirical landscape than was recognised during the lifetime of the GDR or has been recognised since. His ambivalent position is fruitful in prompting us to review and expand our understanding of the production and circulation of both official and unofficial satire in the GDR.
A Systematic Review of Interventions for Algebraic Concepts and Skills of Secondary Students with Learning Disabilities
Authors: Lee Jihyun , Bryant Diane Pedrotty , Ok Min Wook , Shin Mikyung 
Published: April 2020

AbstractImproving the algebraic concepts and skills of secondary school students with learning disabilities is critical for their success in college and in the job market. This research reviewed 12 studies to examine interventions for students with learning disabilities in relation to algebraic notions and competencies. The results indicate that in regard to the Common Core State Standards for Mathematics (CCSSM) Content Standards, the majority of the studies address linear equations and expressions, linear inequalities, and quadratic expressions; they show that following interventions, students’ performance improved with respect to algebraic concepts and skills. The Tau‐U and Hedges’ g of the intervention effects computed were typically large or very large. The most commonly used instructional components in the interventions were multiple representations, a sequence and/or range of examples, and explicit instruction. Limitations and suggestions for future research are discussed.
Solving equations with fractions: An analysis of prospective teachers’ solution pathways and errors
Authors: Jones Dustin L. , Zientek Linda Reichwein , Sharon Valerie V. , Swarthout Mary B. 
Published: April 2020

AbstractWe analyzed the solution pathways and errors found in the written responses of 469 prospective teachers solving an equation containing fractions. The majority (332, or 70%) used an algebraic method; 141 of the 332 (42%) were correct, and 22% of the algebraic methods were abandoned before a solution was obtained. We identified the steps in the written solutions, determined which solution pathways led to the correct solution, and identified common errors in the solution pathways of respondents who incorrectly solved the equation. Respondents initially attempted different methods. The most common method was solving by using fractions, but the majority of respondents who solved by using mixed numbers were able to correctly solve the problem. Common errors related to fraction arithmetic and the distributive property. Nearly all of the abandoned pathways contained no errors, but ended with a step that likely would precede an operation with fractions. Our findings suggest that the ability to solve an arithmetic equation with no fractions was necessary, but not sufficient, to solve an arithmetic equation involving fractions, and that the problem of solving equations with fractions was more closely tied to one's difficulties with rational number arithmetic and less with one's understanding of algebra.
Involvement of Protein Kinase C inRickettsia rickettsii-Induced Transcriptional Activation of the Host Endothelial Cell
Authors: Sahni Sanjeev K. , Turpin Loel C. , Brown Tracy L. , Sporn Lee Ann 
Published: April 2020

ABSTRACTOur laboratory has reported on a biphasic pattern of nuclear factor κB (NF-κB) activation in cultured human umbilical vein endothelial cells during infection withRickettsia rickettsii, an obligate, intracellular bacterium, and the etiologic agent of Rocky Mountain spotted fever. Transcriptional activation of the tissue factor (TF) gene during this infection has been shown to involve NF-κB. To further understand the signal transduction events underlying these phenomena, we studied the role of protein kinase C (PKC), a ubiquitous family of phospholipid-dependent enzymes implicated in the regulation of a variety of cell signaling pathways. Two inhibitors of PKC, namely, bisindolylmaleimide I hydrochloride (BM-1) and calphostin C, which exhibit different inhibitory properties towards various isozymes of PKC, were used. Infection of cells withR. rickettsiiin the presence of BM-1 (50 nM) did not significantly affect NF-κB, whereas calphostin C (2.5 μM) completely blocked the early phase of NF-κB activation. The late, sustained phase also was not affected by treatment with BM-1. Downregulation of phorbol ester-sensitive PKCs by long-term treatment with phorbol 12-myristate 13-acetate (PMA) did not inhibit NF-κB activation. Likewise, this downregulation had no effect on induction of TF activity. The activity of TF was, however, sensitive to BM-1 and calphostin C, whereas expression of TF mRNA was inhibited only by calphostin C. Overall, these results suggest the lack of involvement of classical PKC pathways inR. rickettsii-induced NF-κB activation but the possible involvement of a non-PMA-responsive PKC isoform in the posttranscriptional control of TF expression.
Cloning, Expression, Sequence Analysis, and Characterization of Streptokinases Secreted by Porcine and Equine Isolates of
Streptococcus equisimilis
Authors: Caballero Armando R. , Lottenberg Richard , Johnston Kenneth H. 
Published: April 2020

ABSTRACT

Streptokinases secreted by nonhuman isolates of group C streptococci (
Streptococcus equi
,
S. equisimilis
, and
S. zooepidemicus
) have been shown to bind to different mammalian plasminogens but exhibit preferential plasminogen activity. The streptokinase genes from
S. equisimilis
strains which activated either equine or porcine plasminogen were cloned, sequenced, and expressed in
Escherichia coli
. The streptokinase secreted by the equine isolate had little similarity to any known streptokinases secreted by either human or porcine isolates. The streptokinase secreted by the porcine isolate had limited structural and functional similarities to streptokinases secreted by human isolates. Plasminogen activation studies with immobilized (His)
6
-tagged recombinant streptokinases indicated that these recombinant streptokinases interacted with plasminogen in a manner similar to that observed when streptokinase and plasminogen interact in the fluid phase. Analysis of the cleavage products of the streptokinase-plasminogen interaction indicated that human, equine, and porcine plasminogens were all cleaved at the same highly conserved site. The site at which streptokinase was cleaved to form altered streptokinase (Sk*) was also determined. This study confirmed not only the presence of streptokinases in nonhuman
S. equisimilis
isolates but also that these proteins belong to a family of plasminogen activators more diverse than previously thought.
Species Specificity of Plasminogen Activation and Acquisition of Surface-Associated Proteolytic Activity by Group C Streptococci Grown in Plasma
Authors: Schroeder Brett , Boyle Michael D. P. , Sheerin Barbara R. , Asbury Atwood C. , Lottenberg Richard 
Published: April 2020

ABSTRACT

Our laboratory previously demonstrated that group C streptococcal isolates from humans and horses secrete streptokinases that preferentially activate plasminogens reflecting the origin of the isolates. To analyze the significance of these findings, series of streptokinase-producing
Streptococcus equisimilis
isolates recovered from humans and horses were examined. Southern blot analysis revealed that chromosomal DNA of the streptococcal isolates from humans reacted exclusively with a
skc
hu
probe and that chromosomal DNA of streptococcal isolates from horses reacted preferentially with an
skc
eq
probe in a distinct pattern. The streptococcal isolates were examined for the ability to acquire surface-bound plasmin-like activity when grown in the presence of human or equine plasma. Each of eight isolates from humans acquired significant enzymatic activity only when grown in the presence of human plasma, while each of eight isolates from horses acquired activity only when grown in the presence of equine plasma. Analysis of bacterial and host protein requirements indicated critical roles for streptokinase, activatable plasminogen, and fibrinogen. These requirements may explain why certain streptococcal isolates cause disease only in a limited number of mammalian hosts.
Misoprostol for the prevention of post-partum haemorrhage in Mozambique: an analysis of the interface between human rights, maternal health and development
Authors: Hobday Karen , Zwi Anthony B. , Homer Caroline , Kirkham Renae , Hulme Jennifer , Wate Páscoa Zualo , Prata Ndola 
Published: April 2020

Abstract
Background
Mozambique has high maternal mortality which is compounded by limited human resources for health, weak access to health services, and poor development indicators. In 2011, the Mozambique Ministry of Health (MoH) approved the distribution of misoprostol for the prevention of post-partum haemorrhage (PPH) at home births where oxytocin is not available. Misoprostol can be administered by a traditional birth attendant or self-administered. The objective of this paper is to examine, through applying a human rights lens, the broader contextual, policy and institutional issues that have influenced and impacted the early implementation of misoprostol for the prevention of PPH. We explore the utility of rights-based framework to inform this particular program, with implications for sexual and reproductive health programs more broadly.

Methods
A human rights, health and development framework was used to analyse the early expansion phase of the scale-up of Mozambique’s misoprostol program in two provinces. A policy document review was undertaken to contextualize the human rights, health and development setting in Mozambique. Qualitative primary data from a program evaluation of misoprostol for the prevention of PPH was then analysed using a human rights lens; these results are presented alongside three examples where rights are constrained.

Results
Structural and institutional challenges exacerbated gaps in the misoprostol program, and sexual and reproductive health more generally. While enshrined in the constitution and within health policy documents, human rights were not fully met and many individuals in the study were unaware of their rights. Lack of information about the purpose of misoprostol and how to access the medication contributed to power imbalances between the state, health care workers and beneficiaries. The accessibility of misoprostol was further limited due to dynamics of power and control.

Conclusions
Applying a rights-based approach to the Mozambican misoprostol program is helpful in contextualising and informing the practical changes needed to improve access to misoprostol as an essential medicine, and in turn, preventing PPH. This study adds to the evidence of the interconnection between human rights, health and development and the importance of integrating the concepts to ensure women’s rights are prioritized within health service delivery.
Radiation dosimetry of 18F-AzaFol: A first in-human use of a folate receptor PET tracer
Authors: Gnesin Silvano , Müller Joachim , Burger Irene A. , Meisel Alexander , Siano Marco , Früh Martin , Choschzick Matthias , Müller Cristina , Schibli Roger , Ametamey Simon M. , Kaufmann Philipp A. , Treyer Valerie , Prior John O. , Schaefer Niklaus 
Published: April 2020

Abstract
Background
The folate receptor alpha (FRα) is an interesting target for imaging and therapy of different cancers. We present the first in-human radiation dosimetry and radiation safety results acquired within a prospective, multicentric trial (NCT03242993) evaluating the 18F-AzaFol (3′-aza-2′-[18F]fluorofolic acid) as the first clinically assessed PET tracer targeting the FRα.

Material and methods
Six eligible patients presented a histologically confirmed adenocarcinoma of the lung with measurable lesions (≥ 10 mm according to RECIST 1.1). TOF-PET images were acquired at 3, 11, 18, 30, 40, 50, and 60 min after the intravenous injection of 327 MBq (range 299–399 MBq) of 18F-AzaFol to establish dosimetry. Organ absorbed doses (AD), tumor AD, and patient effective doses (E) were assessed using the OLINDA/EXM v.2.0 software and compared with pre-clinical results.

Results
No serious related adverse events were observed. The highest AD were in the liver, the kidneys, the urinary bladder, and the spleen (51.9, 45.8, 39.1, and 35.4 μGy/MBq, respectively). Estimated patient and gender-averaged E were 18.0 ± 2.6 and 19.7 ± 1.4 μSv/MBq, respectively. E in-human exceeded the value of 14.0 μSv/MBq extrapolated from pre-clinical data. Average tumor AD was 34.8 μGy/MBq (range 13.6–60.5 μGy/MBq).

Conclusions
18F-Azafol is a PET agent with favorable dosimetric properties and a reasonable radiation dose burden for patients which merits further evaluation to assess its performance.

Trial registration
ClinicalTrial.gov, NCT03242993, posted on August 8, 2017
Powerful or powerless? Beyond power and powerlessness: the Leipzig Leadership Model provides some answers
Authors: Meynhardt Timo , Kirchgeorg Manfred , Suchanek Andreas , Zülch Henning 
Published: April 2020

AbstractLeadership is about more than simply wielding power. The Leipzig Leadership Model places the importance of consistently contributing to a greater good at the centre of the concept of leadership. The critical factor is what leaders use their power for and what they use as orientation in the process. In this article, we describe the model and its guiding idea. The model incorporates the conviction that, in a fundamentally uncontrollable world, it is important to remain capable of acting and develop an attitude whereby leaders define themselves through a value contribution rather than status, knowledge, or power.
Analisis Sistem Penyaliran Tambang pada Tailing Storage Facility (TSF) PT. Aneka Tambang Tbk. Pongkor, Kabupaten Bogor, Jawa Barat
Authors: Winarno Tri , Ali Rinal Khaidar , Mursaliin Muh. 
Published: April 2020

Pembangunan dam TSF (Tailing Storage Facility) dibangun untuk menampung limbah hasil pengolahan emas UBPE (Unit Bisnis Pertambangan Emas) PT. ANTAM Pongkor. Pembangunan dam TSF telah selesai dilaksanakan, tetapi masih menyisakan beberapa kendala tentang pengontrolan, yang pada akhirnya menimbulkan kendala teknis, yaitu tidak tersedianya lahan lagi untuk menampung tailing hingga pasca tambang. Permasalahan tersebut akan terselesaikan dengan mengetahui berapa lama penampungan TSF yang dibangun bisa menampung volume yang bertambah akibat curah hujan pada periode ulang tertentu dalam jangka waktu tiga tahun ke depan, terutama pada penampungan dam utama TSF. Untuk itu perlu diadakan evaluasi kapasitas tampung pada dam utama untuk mengetahui kemampuan pelayanan aktual TSF hingga tiga tahun ke depan. Metode yang digunakan dalam penelitian ini adalah metode penanggulangan air pada tambang terbuka atau penyaliran tambang. Dari hasil penelitian diketahui bahwa berdasarkan perhitungan tingkat pelayanan dam utama cukup untuk menampung curah hujan dengan periode ulang 2 tahunan, tetapi tidak memenuhi rencana pembangunan yang mampu menampung hingga tiga tahun ke depan. Untuk memperpanjang umur atau tingkat pelayanan maka penulis menyarankan untuk menambahkan pompa dan pengerukan endapan tailing, selain sebagai penambahan umur bangunan juga sebagai penyeimbang. Pengerukan tailing alangkah lebih baik dilakukan pemerataan dalam pengerukannya ini berguna untuk menambah kapasitas tampung dam utama.
APRENDIZADO DE CONTABILIDADE E A PERCEPÇÃO DO CONCEITO DE LUCRO: UM ESTUDO EXPLORATÓRIO
Authors: SANTOS LUIS PAULO GUIMARÃES DOS , FREITAS SHEIZI CALHEIRA , DIAS FILHO JOSÉ MARIA 
Published: April 2020

Objetivo: o estudo procurar verificar se a compreensão do conceito de lucro e valor manifestada pelos indivíduos está associada ao nível de aprendizado formal de contabilidade.
Metodologia: A pesquisa consiste em um estudo de comparação de grupos, mediante a qual foram analisadas três amostras de sujeitos com diferentes níveis de aprendizado em contabilidade. Através de um modelo logístico, investigou-se ainda outros fatores que podem influenciar no entendimento subjacente ao conceito de lucro.
Resultados e contribuições: os resultados sugerem que não existe relação significativa entre a compreensão do conceito de lucro e o nível de aprendizado formal de contabilidade. Entretanto, observou-se que o fato de o sujeito pertencer ao gênero feminino pode exercer influência na maneira como o lucro é compreendido. Esses achados contribuem para a compreensão de como o processo formal de ensino está relacionado ao aprendizado de conceitos contábeis fundamentais e podem ser pode úteis para orientar estratégias de ensino e até mesmo os projetos político-pedagógico dos cursos de Ciências Contábeis.
SHAPE: A MATLAB Software Package for Time-Dependent Seismic Hazard Analysis
Authors: Leptokaropoulos Konstantinos , Lasocki Stanisław 
Published: April 2020

AbstractMany seismic processes, in particular, those induced by technological activities for exploitation of georesources, are time dependent. The changes in time of the seismicity cause that the related seismic hazard changes in time as well. We present here the Seismic HAzard Parameters Evaluation (SHAPE) tool, which enables an assessment of the temporal changes of the mean return period (MRP) of a seismic event of a given magnitude and the exceedance probability (EP) of a given magnitude within a predefined time period. SHAPE is an open-source software package, written in MATLAB (see Data and Resources), based on the online probabilistic seismic hazard analysis applications available on IS-EPOS platform of thematic core service anthropogenic hazards of European Plate Observing System (EPOS). SHAPE is developed in two standalone versions allowing the user to select a variety of options and parameters to determine the values of EP and MRP, assuming different magnitude distribution models. The first software version (SHAPE_ver1) provides interactive parameter selection and data filtering through a graphical user interface environment, whereas the second wrapper-script-based version (SHAPE_ver2) allows fast implementation and fine-tuning of parameters. The program is particularly useful for anthropogenic seismicity cases, to monitor the changes of seismic response to technological operations, and to control the effectiveness of the undertaken hazard mitigation measures. As an example, two applications of SHAPE in case studies from the northwestern part of The Geysers geothermal field, California, and Song Tranh 2 surface water reservoir, Vietnam, are demonstrated.
Identify Compliance During Software Development Using System Engineering Principles
Authors: Tretyakov A.O. , Druzhinin M.V. 
Published: April 2020

Errors made during the requirements collection and analysis phase make it very difficult to maintain the software product and cost the company extra costs. The difficulty of directly collecting requirements from stakeholders is due to inconsistencies between the major stakeholder groups, as well as related factors in the collection of requirements itself, as well as the selected methodology for the process of converting stakeholder requirements into development requirements. As a solution, it is necessary to use a high level of prioritization in order to distinguish among many requirements the necessary for successful implementation of the product, as well as to correctly allocate compliance with the requirements in such a way that each group of stakeholders is satisfied, but at the same time setting the goals of the supersystem more priority than the goals of the subsystem. This article discusses the methodology of system engineering to solve issues related to the identification of possible contradictions of requirements.
Keywords: System engineering, requirements engineering, business process, requirements, software product, analysis.