bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing the care of children with chronic diseases through the narratives of patient, physician, nurse and carer
Authors: Continisio Grazia I. , Nunziata Francesco , Coppola Clara , Bruzzese Dario , Spagnuolo Maria I. , Guarino Alfredo 
Published: November 2020

We tested the hypothesis that a narrative approach may enhance a bio‐psycho‐social model (BPS) in caring for chronically ill children. Forty‐eight narratives were collected from 12 children with six different medical conditions, their mothers, physicians, and nurses. By a textual analysis, narratives were classified on their predominant focus as disease (biological focus), illness (psychologic focus), or sickness (social focus).Sixty‐one percent of narrative’ text were classified as illness, 28% as disease and 11% as sickness. All narratives had a degree of illness focus. Narratives by patients and physicians on the one hand, and nurses’ and mothers’ on the other were disease focused. Narratives were also evaluated with respect to the type of medical condition: Illness was largely prevalent in all but Crohn’s disease and HIV infection, the latter having a predominance of sickness most probably related to stigma.Narrative exploration proved a valuable tool for understanding and addressing the needs of children with complex conditions. Narrative approaches allow identification of the major needs of different patients according to health conditions and story tellers. In the narratives, we found a greater illness and disease focus and surprisingly a low sickness focus, except with HIV stories.Narrative medicine provides a tool to strengthen the BPS model in health care.
Comparison of Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification in Shallow Anterior Chambers and Glaucoma
Authors: Zhou Zhou , Li Li , Zeng Siming , He Wenjing , Li Min 
Published: November 2020

Purpose. To compare femtosecond laser-assisted cataract surgery (FLACS) versus conventional phacoemulsification in shallow anterior chamber cataract patients with glaucoma or zonulysis. Methods. This was a single-center retrospective review of cataract surgeries in shallow anterior chamber and glaucoma patients between January 2016 and December 2018 in which a LenSx femtosecond laser was used. The outcome measures included pre- and postoperative uncorrected and corrected distance visual acuity (UDVA and CDVA), intraocular pressure (IOP), endothelial cell density (ECD), endothelial cell loss (ECL), and object scatter index (OSI). Results. One hundred and six eyes of 106 patients with a mean anterior chamber depth of 1.54 ± 0.51 mm were included in this study. Among them, 26 (23.2%) had zonulysis and 18 eyes had capsular tension ring implantation in general. The percentage of capsular tension ring implantation was statistically significantly lower in the FLACS group (

P

= 0.027). The UDVA, CDVA, ECD, and IOP were not statistically significant between the two groups at all time points. The postoperative ECL and OSI of the FLACS group was better than those of the conventional group (

P

< 0.01). Conclusions. FLACS can reduce ECL and improve visual quality compared to the conventional phacoemulsification in shallow anterior chamber patients. Also, it has the trend of reducing the use of capsular tension rings in subluxated cataracts. It is an ideal choice for patients with complicated cataract such as with shallow anterior chambers, glaucoma, and zonulysis.
The Navel, Reflections on the composition of the Quarta pars Digestorum
Authors: Zwalve W.J. , de Vries Th. 
Published: November 2020

Summary
In an earlier edition of Tijdschrift voor Rechtsgeschiedenis we have contended that Justinian’s Digest was composed on the basis of Ulpian’s Libri ad Edictum and the peculiarities and special exigencies of the legal curriculum. It was also contended that the distribution of the fifty books over the seven partes of the Digest was based on a mathematical formula, complicated by the fact that Justinian (Tribonian) had decided to assign four books to the first pars (Ta prota) and 36 to the first five partes together according to ‘the nature and science of numbers’ (natura et ars numerorum). This article offers some additional arguments supporting our thesis and concentrates on the composition of the quarta pars Digestorum, designated by Justinian himself as ‘The Navel’ (Umbilicus) of the entire composition. The hypothesis is that Tribonian composed the quarta pars Digestorum as a microcosm of the Digest as a whole and that he has been ‘juggling with numbers’ within the composition of ‘The Navel’ as he has ostensibly done in the composition of the Digest as a whole.
The Palaearctic types of Chrysididae (Insecta, Hymenoptera) deposited in the Linsenmaier collection. Part 1. Cleptes Latreille
Authors: ROSA PAOLO , HEIM RENÉ , BERNASCONI MARCO VALERIO 
Published: November 2020

An illustrated catalogue of the Palaearctic types of Cleptes species and subspecies described by Walter Linsenmaier is given. All types are currently housed at the Natur-Museum, Luzern, Switzerland. Cleptes laevifacies Linsenmaier, 1999 is confirmed as a member of the nitidulus species group.
Ciraparantag, an anticoagulant reversal drug: mechanism of action, pharmacokinetics, and reversal of anticoagulants
Authors: Ansell Jack , Laulicht Bryan E. , Bakhru Sasha H. , Burnett Allison , Jiang Xuan , Chen Lirong , Baker Christopher , Villano Stephen , Steiner Solomon 
Published: November 2020

Abstract
Ciraparantag, an anticoagulant reversal agent, is a small molecule specifically designed to bind noncovalently by charge-charge interaction to unfractionated heparin and low-molecular-weight heparin. It shows binding characteristics that are similar to those of direct oral anticoagulants (DOACs). A dynamic light-scattering methodology was used to demonstrate ciraparantag’s binding to the heparins and DOACs and its lack of binding to a variety of proteins including coagulation factors and commonly used drugs. Ciraparantag reaches maximum concentration within minutes after IV administration with a half-life of 12 to 19 minutes. It is primarily hydrolyzed by serum peptidases into 2 metabolites, neither of which has substantial activity. Ciraparantag and its metabolites are recovered almost entirely in the urine. In animal models of bleeding (rat tail transection and liver laceration), a single IV dose of ciraparantag given at peak concentrations of the anticoagulant, but before the bleeding injury, significantly reduced the blood loss. Ciraparantag, given after the bleeding injury, also significantly reduced blood loss. It appears to have substantial ability to reduce blood loss in animal models in which a variety of anticoagulants are used and has potential as a useful DOAC reversal agent.
The failure of glomerular filtration rate estimating equations among obese population
Authors: Kittiskulnam Piyawan , Tiskajornsiri Krittaya , Katavetin Pisut , Chaiwatanarat Tawatchai , Eiam-Ong Somchai , Praditpornsilpa Kearkiat 
Published: November 2020

Background
Obesity is a major public health with increasing numbers of obese individuals are at risk for kidney disease. However, the validity of serum creatinine-based glomerular filtration rate (GFR) estimating equations in obese population is yet to be determined.

Methods
We evaluated the performance of the reexpressed Modification of Diet in Renal Disease (MDRD), reexpressed MDRD with Thai racial factor, Thai estimated GFR (eGFR) as well as Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations among obese patients, defined as body mass index (BMI) ≥25 kg/m2 with the reference measured GFR (mGFR) determined by 99mTc-diethylene triamine penta-acetic acid (99mTc-DTPA) plasma clearance method. Serum creatinine levels were measured using standardized enzymatic method simultaneously with GFR measurement. The statistical methods in assessing agreement for continuous data including total deviation index (TDI), concordance correlation coefficient (CCC), and coverage probability (CP) for each estimating equation were compared with the reference mGFR. Accuracy within 10% representing the percentage of estimations falling within the range of ±10% of mGFR values for all equations were also tested.

Results
A total of 240 Thai obese patients were finally recruited with mean BMI of 31.5 ± 5.8 kg/m2. In the total population, all eGFR equations underestimated the reference mGFR. The average TDI values were 55% indicating that 90% of the estimates falling within the range of -55 to +55% of the reference mGFR. The CP values averaged 0.23 and CCC scores ranged from 0.75 to 0.81, reflecting the low to moderate levels of agreement between each eGFR equation and the reference mGFR. The proportions of patients achieving accuracy 10% ranged from 23% for the reexpressed MDRD equation to 33% for the Thai eGFR formula. Among participants with BMI more than 35 kg/m2 (n = 48), the mean error of all equations was extremely wide and significantly higher for all equations compared with the lower BMI category. Also, the strength of agreement evaluated by TDI, CCC, and CP were low in the subset of patients with BMI ≥35 kg/m2.

Conclusion
Estimating equations generally underestimated the reference mGFR in subjects with obesity. The overall performance of GFR estimating equations demonstrated poor concordance with the reference mGFR among individuals with high BMI levels. In certain clinical settings such as decision for dialysis initiation, the direct measurements of GFR are required to establish real renal function among obese population.
Cardiometabolic and psychological effects of dual-release hydrocortisone: a cross-over study
Authors: Dineen Rosemary , Martin-Grace Julie , Ahmed Khalid Mohamed Saeed , Frizelle Isolda , Gunness Anjuli , Garrahy Aoife , Hannon Anne Marie , O’Reilly Michael W , Smith Diarmuid , McDermott John , Healy Marie-Louise , Agha Amar , Pazderska Agnieszka , Gibney James , Thompson Chris J , Behan Lucy-Ann , Sherlock Mark 
Published: November 2020

Background
Adrenal insufficiency (AI) is associated with increased cardiovascular morbidity and mortality and reduced quality of life (QoL). Optimum glucocorticoid (GC) dosing and timing are crucial in the treatment of AI, yet the natural circadian secretion of cortisol is difficult to mimic. The once-daily dual-release hydrocortisone (DR-HC) preparation (Plenadren®), offers a more physiological cortisol profile and may address unmet needs.

Methods
An investigator-initiated, prospective, cross-over study in patients with AI. Following baseline assessment of cardiometabolic risk factors and QoL, patients switched from their usual hydrocortisone regimen to a once-daily dose equivalent of DR-HC and were reassessed after 12 weeks of treatment.

Results
Fifty-one patients (21 PAI/30 SAI) completed the study. Mean age was 41.6 years (s.d. 13), and 58% (n = 30) were male. The median daily HC dose before study entry was 20 mg (IQR 15–20 mg). After 3 months on DR-HC, the mean SBP decreased by 5.7 mmHg, P = 0.0019 and DBP decreased by 4.5 mmHg, P = 0.0011. There was also a significant reduction in mean body weight (−1.23 kg, P = 0.006) and BMI (−0.3 kg/m2, P = 0.003). In a sub-analysis, there was a greater reduction in SBP observed in patients with SAI when compared to PAI post-DR-HC. Patients reported significant improvements in QoL using three validated QoL questionnaires, with a greater improvement in PAI.

Conclusion
Dual-release hydrocortisone decreases BP, weight and BMI compared with conventional HC treatment, even at physiological GC replacement doses. Additionally, DR-HC confers significant improvements in QoL compared to immediate-release HC, particularly in patients with PAI, which is also reflected in the patient preference for DR-HC.
Harmadikablak-szindróma – osztályozás, diagnózis, terápia
Authors: Kalinics Péter , Gerlinger Imre , Révész Péter , Bakó Péter , Végh Ildikó , Kovács Márton , Fehér Attila 
Published: November 2020

Összefoglaló. Halláspanasszal számos beteg fordul orvoshoz. A
rutinszerűen elvégzett súgottbeszéd-, hangvilla- és
tisztahangküszöb-audiometriai vizsgálat alapján vezetéses, sensorineuralis,
illetve a kettő együttes fennállása esetén kevert típusú halláscsökkenést
különböztetünk meg. Vezetéses halláscsökkenés létrejöhet mind a külső, mind a
közép- vagy a belső fül veleszületett vagy szerzett rendellenességei esetén.
Amennyiben a stapediusreflex kiváltható, ugyanakkor a betegnél nincs jelen a
külső fület, valamint a középfület érintő kórfolyamat, felmerül a
harmadikablak-szindróma lehetősége. A kórkép okaként egy, a belső fül csontos
tokján „harmadik ablakként” funkcionáló laesio van jelen, amely az ovális
ablakon keresztül beérkező hangenergia egy részét elvezeti, mielőtt az a kerek
ablakon át kivezetődik a középfülbe. A diagnózis felállítása gyakran nehéz
feladat elé állítja a klinikust, melyhez a megfelelő audiológiai, illetve
képalkotó vizsgálatok elvégzése elengedhetetlen. Tekintettel arra, hogy a
panaszok megszüntetésére számos műtéti módszer került leírásra, közleményünkben
átfogó képet adunk a kórkép etiológiájáról, diagnosztikájáról, terápiájáról,
valamint bemutatjuk saját kezdeti tapasztalatainkat is 2 eset prezentálásával.
Orv Hetil. 2020; 161(46): 1944–1952.
Summary. Patients frequently present to the physician with hearing
loss. Routine hearing tests include speech field (whisper test), tuning forks
and pure tone threshold audiometry, which can identify the presence of
sensorineural hearing loss, conductive hearing loss or a combination of both
(mixed type). Conductive hearing loss can be a symptom of many different
conditions. These include congenital or acquired malformations of the outer,
middle and inner ear. If a conductive hearing loss with intact stapedial
reflexes are recorded and in the absence of outer or middle ear pathology, then
the third window syndrome should be considered. The cause is a bony defect on
the otic capsule that acts as a ’third window’, dissipating the incoming sound
energy. Without the appropriate audiological and imaging tests, the diagnosis of
the condition is challenging in clinical setting. Several surgical techniques
have been described to treat the condition. The authors give a comprehensive
review of the etiology, diagnosis and treatment of the disease presenting their
initial experiences with 2 cases. Orv Hetil. 2020; 161(46): 1944–1952.
Los contenidos digitales en los centros educativos: Situación actual y prospectiva / Digital content in schools: Current and prospective situation
Authors: Santiago Campión Raúl , Maeztu Esparza Víctor Manuel , Andía Celaya Luis Alberto 
Published: November 2020

La realidad de un nuevo paradigma educativo ha hecho que se cuestionen muchos de los elementos que tradicionalmente han acompañado al proceso de enseñanza/aprendizaje. La irrupción de las Tecnologías de la Información y la Comunicación facilita la creación y el acceso a nuevos tipos de materiales didácticos que están provocando una revisión global en la producción de contenidos y en las metodologías a aplicar en el aula. El mundo editorial y los responsables de los diferentes niveles educativos deben afrontar el reto de dar una respuesta a este cambio. En este artículo se pretende ahondar en la percepción que los directivos de los centros escolares muestran sobre los contenidos digitales, sus características más relevantes y su impacto a corto y medio plazo en el mundo educativo. Por regla general, son los dirigentes de las escuelas los que toman decisiones en relación con los planes de formación destinados a la mejora técnica y metodológica. El estudio que aquí se presenta se basa en un diseño metodológico de carácter descriptivo mediante el procedimiento de encuesta. Entre las conclusiones más relevantes se encuentran la necesidad de adaptabilidad de dichos contenidos a diferentes contextos y la importancia del incremento de las competencias digitales de los profesionales a través de una formación sólida y sostenida que permita una correcta inclusión de este tipo de innovación dentro de una más amplia de carácter metodológico.AbstractThe existence of a new educational paradigma has led to the revision of the elements that have traditionally participated in the learning process. The emergence of Information and Comunication Technologies has eased the access to new types of educational materials that are causing a global revision of the contents’ production and methodologies to implement in the classroom. The publishing world and the leaders of the different educational levels have to face the challenge of given an answer to this process of change. This is currently a debate in many schools. The aim of this study is to analyse school leaders' perception of the digital content, their more relevant features and their impact in the educational world in the short and middle term. It is usually the leaders of the schools who make decisions in relation to the training plans aimed at technical and methodological improvement. To do this, the study is based on a methodological descriptive design backed by a survey. Among the conclusions we highlight the need for adaptability of digital contents to different contexts and the requirement of teachers’ training in the pedagogical use of ICT through a solid and sustained formation programme as a strategy to implement this innovation in a larger methodological framework.
Realidad Aumentada en Educación Primaria: efectos sobre el aprendizaje / Augmented Reality in Primary Education: effects on learning
Authors: Toledo Morales Purificación , Sánchez García José Manuel 
Published: November 2020

El uso de Realidad Aumentada (RA) lleva a investigar los efectos de su utilización en los entornos educativos, si modifica y facilita la adquisición de conocimientos, la atención y la motivación, así como el rendimiento académico del alumnado, y las percepciones que tenían tras el uso de este novedosa tecnología. La muestra del estudio la formaron 46 alumnos de dos aulas de 6º de educación primaria de un colegio de la provincia de Sevilla (España), asignados a un grupo control de 22 alumnos y a un grupo experimental de 24 alumnos, con el cual se utilizó herramientas de RA. El diseño cuasi-experimental llevó a utilizar herramientas que recogieron datos de forma cuantitativa y cualitativa. Para la realización de este estudio utilizamos contenidos de RA durante cinco semanas, periodo necesario para impartir el tema seleccionado para el que se crearon contenidos específicos. Su uso reveló una mejora significativa en el proceso de aprendizaje y la adquisición de conocimientos por los alumnos. Se puede apreciar una mejora de las calificaciones, la adquisición de conocimientos y la mejora en el rendimiento que es deseable y beneficiosa. La percepción por parte del alumnado y el profesorado de esta tecnología es positiva y les parece incentivadora, motivadora y capaz de propiciar una mejora en el proceso de enseñanza y aprendizaje.AbstractThe use of Augmented Reality (AR) leads to investigate the effects of its use in educational environments, if it modifies and facilitates the acquisition of knowledge, attention and motivation, as well as the academic performance of students, and the perceptions they had The use of this new technology. The sample of the study was formed by 46 students from two classrooms of 6º of primary education of a school of the province of Seville (Spain), assigned to a control group of 22 students and to an experimental group of 24 students, with which tools were used of AR. The quasi-experimental design led to the use of tools that collected data in a quantitative and qualitative way. To carry out this study we used AR content for five weeks, a period necessary to impart the selected topic for which specific contents were created. Its use revealed a significant improvement in the learning process and the acquisition of knowledge by students. It is possible to appreciate an improvement of the qualifications, the acquisition of knowledge and the improvement in the performance that is desirable and beneficial. The perception by the students and teachers of this technology is positive and seems encouraging, motivating and capable of promoting an improvement in the teaching and learning process.
Co-movement and Lead–Lag Relationship Between Green Bonds and Renewable Energy Stock Markets: Fresh Evidence from the Wavelet-Based Approach
Authors: Liu Nana , Liu Chuanzhe 
Published: November 2020

Abstract
Background: A recent study in Nature Climate Change shows that due to reduced human activities during the Coronavirus disease 2019 (COVID-19) pandemics, daily global emissions of carbon dioxide decreased by 17% from the average level in 2019. With the gradual recovery of economic activity and human energy consumption, the emissions of greenhouse gas and pollution would rise again. Green bonds are considered a crucial tool to release climate finance. The green bond market can act as an essential bridge between capital providers (i.e. institutional investors) and sustainable assets (i.e. renewable energy).This study is the first attempt to examine co-movement and the lead–lag relationship between green bonds and global and sector renewable energy stock markets in the time and frequency horizons. We apply continuous wavelet, wavelet coherence, and line and non-line causality approaches on data during the period 2010–2020, coincidentally including the COVID-19 pandemic.Results: (1) Green bonds and renewable energy markets show evidence of a similar pattern based on the wavelet power spectrum, which shows high price volatility at small and medium scales, especially during periods of turbulence and crisis. (2) The dynamic connection between green bonds and renewable energy returns is weak (strong) on the short (long) time-scale. However, on medium-term time scales, the dependence between them is significant only during turbulent periods, such as the European Sovereign Debt Crisis 2012 (ESDC) and the COVID-19 pandemic. (3) With regard to causality, our results show unidirectional and bidirectional linear (non-linear) causality at low and high frequencies. Moreover, our finding reveals the fact regarding the lead–lag relationship that, most of the time and frequencies, no one market necessarily dominates the other.Conclusion: Our findings provide several remarkable policies and practical implications for market regulators and investors. Institutional investors can benefit by including green bonds in their portfolios to decrease their climate change risk and improve their environmental, social, and corporate governance rating in the portfolio. Considering that the dependence between green bonds and renewable energy stock prices varies over various time scales, investors with different investment horizons should make diverse investment portfolio and hedging choices. The finding is also relevant for formulating green finance policies and supporting renewable energy investments. Policy decisions on the transition of energy to a decarbonized economy should consider the consequences for green bonds, which are also critical for the transition to a climate-resilient economy.