bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leitura de mídias móveis como estratégia complementar de projeto
Authors: Faria Gustavo Henrique Campos de , Vaz Carlos Eduardo Verzola , Correa Sara Dotta , Souza Larissa Pereira de 
Published: December 2020

O uso de dispositivos móveis e a emergência da cultura de aplicativos proporcionam novas formas de interação entre sujeito e espaço, promovendo conexão, aprendizado e inovação considerados positivos para a vivência nas cidades. Com isso, a presente pesquisa buscou investigar diversas classes de aplicativos móveis, por intermédio de uma oficina pedagógica com estudantes de Arquitetura e Urbanismo, realizando análises e leituras de objetos midiáticos, com a aplicação do método close reading com lente analítica das poéticas das novas mídias. A ideia principal das poéticas é tornar presente para a consciência humana novas camadas de significação e existência, desvendando e revelando mundos a partir da produção de significados e realidades da cidade permeada por mídias móveis. Os dados do experimento foram coletados por meio de questionários, observação participante e grupo focal, os quais foram tratados pela análise de conteúdo da construção do discurso do sujeito coletivo, triangulados juntamente com a literatura existente (remediação, hipermediação e imediação, narrativa, interatividade e agência). Frente ao experimento pedagógico, foi possível compreender como os estudantes consideram e avaliam as possibilidades de pensar criticamente sobre o espaço mediado por mídias móveis. Além disso, os insights obtidos pelas análises podem se tornar informações complementares no diagnóstico arquitetônico, o que pode direcionar a novas possibilidades de solução de projeto. Observou-se também, que as possíveis intervenções podem se materializar em diversas escalas, constituindo-se de intervenções físicas até intervenções legais no âmbito da cidade.
Proposta de modelagem de processos para apoiar a implementação do processo de gestão de requisitos do MPS.BR
Authors: Lamonica Barreto Deivison , Rangel de Matos Mariane , F. Garcez Luiz Carlos , Vasconcelos Silva Simone , Pires Vieira de Vasconcelos Aline , Sardinha Cordeiro Morais Alline 
Published: December 2020

Destaques: A qualidade de requisitos é de grande importância para o sucesso de um software, tanto em relação ao seu funcionamento quanto aos custos envolvidos no processo de desenvolvimento. A Gerência de Requisitos é um processo importante da engenharia de software e o presente trabalho apresenta uma abordagem sobre a qualidade de requisitos com foco no Processo de Gerência de Requisitos (GRE), presente no nível G do MPS.BR (Melhoria do Processo de Software Brasileiro). O modelo de referência de software do MPS.BR traz os resultados a serem atingidos, porém são de difícil implementação por não apresentarem instruções de como atingir esses resultados. A modelagem de processos, através de modelos visuais, pode ser utilizada como um facilitador para a compreensão e execução destes resultados.
Objetivo: Este trabalho propõe a modelagem das atividades e subprocessos, através da notação BPMN (Business Process Model and Notation), necessária para atingir cada um dos resultados esperados no GRE, onde tal modelagem busca apoiar os profissionais que atuam na implementação do GRE para projetos de desenvolvimento de software.
Metodologia: Encontra-se dividida em quatro etapas: (i) Etapa I - revisão bibliográfica, (ii) Etapa II - análise documental de guias do MPS.BR, (iii) Etapa III – modelagem dos processos através da notação BPMN para a GRE no nível G do MPS.BR, e (iv) validação da modelagem proposta através de pesquisa com profissionais que atuam em áreas relacionadas a TIC (Tecnologia da Informação e Comunicação).
Resultados: A amostra de profissionais que validou os modelos propostos gerou resultados considerados satisfatórios para melhoria da compreensão das atividades necessárias para implantação da gestão de requisitos em projetos de desenvolvimento de software.
Implicações práticas: A principal contribuição prática deste trabalho é facilitar a execução dos resultados esperados do GRE.
Originalidade: a modelagem de processos é proposta como um meio visual para definir as atividades necessárias para se atingir os processos propostos em normas e/ou guias.
PENGARUH MENGIKUTI UNIT BISNIS TERHADAP PENINGKATAN KETERAMPILAN DAN MOTIVASI BERWIRAUSAHA PADA SANTRI
Authors: Anggrayani Deni , Susanto Ari , Al Baqi Safiruddin 
Published: December 2020

As education systems, Islamic boarding school has several advantages such as teaching religious knowledge, science and various extracurricular activities. Modern Islamic Boarding School of Darussalam GontorInodonesia is a boarding school that has a holistic education system, which is not only educate the academic skill but also educate students in developing entrepreneurship skills. This study aims to determine the effect of joining the business unit to the motivation and ability of entrepreneurship among students. This research used ethnography method with interviews and observations in business units in Darussalam Gontor. The results of this study indicate that Darussalam Gontoris a boarding school which implements 24-hour education system with various activities, such as praying togather, muajjah, learning in class, sports, mahkamatullughohand others. Differences of Darussalam Gontor with other boarding school is because Darussalam Gontor requires senior student to be responsible for business unit, such as Darussalam Press, Wisma Darussalam, La Tansa bookstore and other units. Result of this study shows that after joining the business unit, students become more motivated to develop their own business. Students also get enough knowledge to start a business or become an entrepreneur. The data showed that many alumni who have success become entrepreneurs. The entrepreneur character is heavily influenced by the role of alumni as a student of Darussalam Gontor. The alumni's businesses include production of songkok, ice cream, bookstore, travel agent, garment businessman and others. Keywords: Business unit, education system, entrepreneurship, Islamic boarding school, Islamic education
Correlation Between MRI Findings and Clinical Impairment In Patients With Shoulder Adhesive Capsulitis: A Prospective Study
Authors: GILLET Romain , ZHU Francois , PADOIN Pierre , HOSSU Gabriella , RAUCH Aymeric , TEIXIERA Pedro Augusto GONDIM , BLUM Alain 
Published: December 2020

Abstract
Objectives:

MRI diagnostic criteria of shoulder adhesive capsulitis (AC) are widely used, but there is little information available on the association between MRI findings and clinical impairment. The aim of our study was to determine the correlation of MRI findings with the Constant-Murlay Score (CMS), pain duration, and symptoms at the one-year follow-up in AC patients.
Methods:

MRI of 132 patients with a clinical diagnosis of shoulder AC were prospectively studied. A radiologist examined all patients and completed the CMS just prior to MRI. Pain duration was assessed. The signal intensity and the maximal thickness of the inferior glenohumeral (IGHL) and coracohumeral (CHL) ligaments were measured by two radiologists. Medical record analysis was performed in a sub-group of 49 patients to assess correlation approximately one year after the MRI examination.
Results:

There was a significant difference in mean pain duration score (3.8 ± 1.2 versus 3.2 ± 0.9 and 3.8 ± 1.2 versus 3.2 ± 0.9 respectively for readers 1 and 2) and in mean mobility scores (15.7 ± 8 points versus 19.6 ± 10.1 points and 15.8 ± 8.2 points versus 19.4 ± 10 points respectively for readers 1 and 2) in patients with a high IGHL signal compared to those with a low signal (P < .05). IGHL was thicker in patients with clinical improvement at one-year follow-up compared to those presenting clinical stability or worsening (P < .05).
Conclusion:

In shoulder AC patients, the degree of signal intensity at the IGHL was inversely related to shoulder pain duration and range of motion, and a thickened IGHL indicated a favorable outcome at one-year follow-up.
Life Expectancy of Older People Living in Aged Care Facilities after a Hip Fracture
Authors: Liu Enwu , Killington Maggie , Cameron Ian , Li Raymond , Kurrle Susan , Crotty Maria 
Published: December 2020

Abstract
Little is known about life expectancy in nursing home residents with hip fracture. We assessed life expectancy of 240 residents of residential aged care facilities who were aged more than 70 years old and experienced recent hip fracture treated with surgery. 149 deaths occurred over a mean follow-up of 1.2 years. Being female (coefficient (β) = 0.86, 95% confidence interval (CI): 0.39, 1.34; p = 0.0004) was associated with longer life expectancy. Increased age was associated with shorter life expectancy (β=-0.06, 95% CI: -0.10 to -0.02, p = 0.0043). Relative to severe cognitive impairment, normal or mild-cognitive impairment (β = 1.18, 95% CI: 0.05 to 2.31, p = 0.0414) and moderate cognitive impairment (β = 0.56, 95% CI: 0.07 to 1.04, p = 0.0237) were associated with longer life expectancy. Mortality rate within three months after hip fracture was 118 cases per 100 person-years while the mortality rate for the whole study period was 51.3 deaths per 100 person-years. For females with hip fracture, life expectancy was 8.2 years at 70 years of age; 4.8 years at 80 years of age; and 2.8 years at 90 years of age. For males with hip fracture, life expectancy was 3.8 years, 2.2 years and 1.3 years at 70, 80 and 90 years of age, respectively.
WITHDRAWN: IL-31, IL-32 and IL-33 may Serve as Diagnosis Biomarkers in Gastric Cancer
Authors: Bao Shisan , Liu Qinghua , Zhang Jiwei , Xia Lei , Wise Steven , Hambly Brett , Tao Kun 
Published: December 2020

Abstract
Background: To determine whether IL-31, IL-32 and IL-33 can be used as biomarkers for the detection of gastric cancer (GC), via evaluating the correlations between IL-31, IL-32 and IL‑33 expression and clinicopathological parameters of GC patients.Methods: Tissue array (n=180) gastric specimens were utilised. IL-31, IL-32 and IL-33 in GC and non-GC tissues were detected immunohistochemically. The correlations between IL-31, IL-32 and IL-33 in GC and severity of clinicopathological parameters were evaluated. Survival curves were plotted using the Kaplan-Meier/Cox regression. IL-31, IL-32 and IL-33 in circulation were detected by ELISA. Results: IL-31, IL-32 and IL-33 were all lower in GC than that in adjacent non-GC gastric tissue (p all <0.05). IL-33 in peripheral blood of GC patients was significantly lower than that of healthy individuals (1.50 ± 1.11 vs 9.61 ± 8.00 ng/ml) (p<0.05). Decreased IL-31, IL-32 and IL-33 in GC were observed in younger patients (<60 years), and IL-32 and IL-33 were lower in female patients (p all <0.05). Higher IL-32 correlated with longer survival in two GC subgroups: T4 invasion depth and TNM I-II stage. Univariate/multivariate analysis revealed that IL-32 is an independent prognostic factor for GC within the T4 stage subgroup. Circulation IL-33 was significantly lower in GC patients than healthy people (p <0.05). Conclusions: Our findings provide new insights into the roles of IL-31, IL-32 and IL-33 in carcinogenesis of GC and demonstrate their relative usefulness as prognostic markers for GC. The underlying mechanism of IL-31, IL-32 and IL-33 in GC is further discussed.
Development of N6-methyladenosine Related Signature as New Biomarker for Prognosis of Hepatocellular Carcinoma and Correlates with Sorafenib and anti-PD-1 Immunotherapy Treatment Response
Authors: Jiang Hong-ye , Ning Gang , Wang Yensheng , Lv Wei-biao 
Published: December 2020

Abstract
Background: N6-methyladenosine (m6A) modification plays an essential role in diverse key biological processes and may take part in the development and progression of hepatocellular carcinoma (HCC). Here, we systematically analyzed expression profiles and prognostic values of 13 widely reported m6A modification related genes in HCC.Methods: mRNA expression of 13 m6A modification related genes and clinical parameters of HCC patients were downloaded from TCGA, ICGC, GSE109211 and GSE78220. Univariate and LASSO analysis was used to develop risk signature. Time-dependent ROC was performed to assess the predictive accuracy and sensitivity of risk signature.Results: FTO, YTHDC1, YTHDC2, ALKBH5, KIAA1429, HNRNPC, METTL3, RBM15, YTHDF2, YTHDF1 and WTAP were significantly overexpressed in HCC patients. YTHDF1, HNRNPC, RBM15, METTL3, YTHDF2 were independent prognostic factors for OS and DFS in HCC patients. Next, a risk signature was also developed and validated with five m6A modification related genes in TCGA and ICGC HCC cohort. It could effectively stratify HCC patients into high risk patients with shorter OS and DFS and low risk patients with longer OS and DFS and showed good predictive efficiency in predicting OS and DFS. Moreover, significantly higher proportions of macrophages M0 cells, neutrophils and Tregs were found to be enriched in HCC patients with high risk score, while significantly higher proportions of memory CD4 T cells, gamma delta T cells and naive B cells were found to be enriched in HCC patients with high low score. Finally, significantly lower risk scores were found at sorafenib treatment responders and anti-PD-1 immunotherapy responders compared to that in non-responders, and anti-PD-1 immunotherapy treated patients with lower risk score had better OS than patients with higher risk score. Conclusion: A risk signature developed with the expression of 5 m6A related genes could improve the prediction of prognosis of HCC and correlate with sorafenib treatment and anti-PD-1 immunotherapy response.
Absence of miR-378d Promoted The Malignant Phenotype of ESCC Through The AKT-β-Catenin and Hippo-p53 Signaling Pathway
Authors: Peng Jie , Yu Juan , Liu Jianli , Wei Haixiang , Song Haixia , Shi Susu , Wang Shaoqiang , Guo Daolu , Li Zhejie , He Shujin , Feng Xi , Li Lei , Zhao Ran , Liu Yukun , Liu Yanrong , Li Junjun , Zhang Renya , Wang Wei 
Published: December 2020

Abstract
Background: Chemoresistance is an important cause of malignant progression of esophageal squamous cell carcinomas (ESCCs). miR-378d is sharply reduced in paclitaxel (PTX)-resistance esophageal cancer cells by gene-expression profile analysis (RNA-Seq), but the mechanism of miR-378d-mediated tumor progression is unclear. Patients and methods: Herein, we detected miR-378d expression in 596 ESCC patients by in situ hybridization. Results showed that low miR-378d expression was associated with poor prognosis of ESCC patients, and that miR-378d absence enhanced carcinogenesis by promoting chemoresistance, colony formation, EMT, invasion, and metastasis. Results: Furthermore, miR-378d can target downregulated AKT1 expression by binding to the AKT1 mRNA 3′UTR, inactivating the AKT-β-catenin signaling pathway, and reducing the epithelial–mesenchymal transition marker Vimentin and the cancer stem cell marker ALDH1A1. miR-378d silencing in ESCC cells also promoted polyploidy formation in vitro and in vivo, and miR-378d inhibition suppressed the Hippo-p53 signaling pathway. Consequnetly, YAP and TAZ protein accumulated in nuclei and p53 expression decreased, which may promote the formation of ploidy tumor cells. Conclusions: Therefore, low miR-378d expression is a poor prognostic factor of ESCC patients and promotes polyploidy and cancer progression by activating AKT-β-catenin and suppressing the Hippo-p53 signaling pathway.
Anthropometric and Dietary Indicators Applied in Population-based Surveys: a Systematic Review.
Authors: Cabral Natalia , Pequeno Nila , Silva David , Crispim Sandra , Marchioni Dirce , Lima Severina , Lyra Clelia 
Published: December 2020

Abstract
Background: Anthropometric and food consumption indicators are important in dietary, nutritional, and health status conditions assessment and monitoring of the population, as a mechanism to identify changes or trends in consumption and to understand the relationship between dietary exposure and varied health outcomes. The aim was to identify population-based health and nutrition surveys, conducted with adults and the elderly, and performed in the Americas, Europe, and Oceania, in order to investigate the more common anthropometric and food consumption methods used, their applicability, and their limitations. Methods: Electronic databases (LILACS, PubMed, and SCOPUS) were systematically searched for studies published between 1997 and 2017 in Portuguese, English or Spanish. Forty-five studies (49% carried out in the Americas) met the eligibility criteria and were included in the review. The data were analysed in 2018. Results: The methodological quality of most of the studies (64.4%) was classified as moderate, according to the Agency for Healthcare Research and Quality checklist for cross-sectional studies and the Newcastle-Ottawa scale for cohort studies. Forty percent of the articles evaluated only food consumption, 31% just anthropometry, while 29% evaluated food consumption and anthropometric measurements. The most used food survey methods were food record (31% of studies) and the 24-hour dietary recall (22% of studies). Body mass index (BMI) was the most used indicator for anthropometric nutritional status assessment. Although most of the studies used the World Health Organization classification criteria, these studies did not adopt the different cut-off points for BMI classification for adults and the elderly. Conclusion: BMI and methods that record current consumption, such as the food record and the 24-hour dietary recall, were the main methods of assessing nutritional status, taking into consideration the easy application, low cost, and good reproducibility.Systematic Review Registration: PROSPERO CRD42017071392
Effects of Polyunsaturated Fatty Acids Supplementation on The Meat Quality of Pigs: A Meta-Analysis
Authors: Wang Liyi , Huang Yuqin , Shan Tizhong 
Published: December 2020

Abstract
Background: Polyunsaturated fatty acids (PUFAs) supplementation has been widely discussed as a strategy for improving meat quality in pig production but the effects are inconsistent. This meta-analysis was performed to comprehensively evaluate its effects on the meat quality including intramuscular fat (IMF) content, drip loss, meat color, pH 45min and pH 24h of pigs.Methods: We searched the PubMed and Web of Science databases (articles published from Jan 1st, 2000, and Oct 16th, 2020) and compared PUFAs-supplemented diets with control diets. We identified 1670 studies, of which 14 (with data for 752 pigs) were included in our meta-analysis. We used a random-effects model and a fixed-effects model to calculate the weighted mean differences (WMDs) and 95% confidence intervals (CIs). We used sensitivity and subgroup analysis to ensure the pooled estimates are robust. The subgroup analysis was classified as treatment (conjugated linoleic acid (CLA) or linseed), concentration (high or low concentration) and initial stage (growing and finishing pigs).Results: Our analysis found that PUFAs supplementation increased the IMF content (WMD= 0.467%, 95% CI: 0.312 to 0.621, P<0.001), decreased the meat color L* (WMD= -0.636, 95% CI: -1.225 to -0.047, P=0.034) and pH 24h (WMD= -0.021,95% CI: -0.032 to -0.009, P<0.001). CLA supplementation improved IMF content (WMD= 0.542%, 95% CI: 0.343 to 0.741, P<0.001) and reduced meat color b* (WMD= -0.194, 95% CI: -0.344 to -0.044, P=0.011). Linseed supplementation increased IMF content (WMD= 0.307%, 95% CI: 0.047 to 0.566, P=0.021), decreased meat color L*(WMD= -1.740, 95% CI: -3.267 to -0.213, P=0.026) and pH 24h (WMD= -0.034, 95% CI: -0.049 to -0.018, P<0.001). We discovered an increase on IMF content in both high and low concentration PUFAs supplementation (WMD= 0.461%, 95% CI: -0.344 to -0.044, P<0.001; WMD= 0.456%, 95% CI: 0.276 to 0.635, P<0.001). Besides, we also found the effects of PUFAs supplementation on meat color L* and pH 24h are concentration- and stage-dependent.Conclusions: PUFAs supplementation can improve meat quality of pigs which mainly emerge in greatly increasing IMF content.
Effect of preoperative information about pain on postoperative pain experience and patient satisfaction following orthopaedic surgery: A randomised controlled trial.
Authors: Othin Moses , Sendagire Cornelius , Mukisa John , Lubulwa Clare , Mulepo Phillip , Wabule Agnes , Ayebale Emmanuel 
Published: December 2020

Abstract
Background: Preoperative information about pain has been shown to improve postoperative pain perception and reduce postoperative analgesia requirements. However, there is limited data regarding the effect of preoperative counselling in low resource settings. This study aimed at assessing the effect of preoperative information about pain on postoperative pain experience measured as postoperative pain using a verbal numerical rating scale (VNRS) and patient satisfaction with pain management. Methods: A randomised, double blind, controlled trial was done in Mulago National Referral Hospital (MNRH), Kampala. We prospectively enrolled 400 participants aged 18years and above scheduled for elective orthopaedic surgery. The consented patients were randomised to either receive the specific preoperative information about pain or not. The primary end points were postoperative pain score and patient satisfaction. A total of 340 were analysed with 170 in either arm. Secondary analyses where done to determine the factors that were associated with postoperative pain and patient satisfaction.Results: In both arms, the lowest pain score was 0/10 at 0 hours and the highest was 7/10 at 12 hours. A statistically significant difference between the intervention and control arms for the median pain score at 48hours (4/10 vs. 5/10) P-value= 0.029 was seen but none at 0, 12, 24hours. There was no difference in satisfaction with pain management (P value=0.059). Conclusion: Preoperative information about pain improves postoperative pain experience and may negatively impact patients’ satisfaction with pain management due to unmet expectations.Trial registration: Clinicaltrials.gov, NCT03056521. Registered 17 February 2017 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03056521