bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is There Currently an Established Role for the Use of Predictive or Prognostic Molecular Markers in the Management of Colorectal Cancer? A Point/Counterpoint
Authors: Venook Alan P. , Bendell Johanna C. , Warren Robert S. 
Published: February 2020

Overview: The term “personalized oncology” means different things to the oncologist than to the patient. But fundamentally, the phrase creates the expectation that decisions can be informed by the unique features of the patient and patient's cancer. Much like determining antibiotic sensitivities in urinary tract infections, the oncologist is expected to choose the right treatment(s), for each individual patient. Numerous methods can be used to “personalize” management decisions, although truly useful biomarkers continue to escape our grasp. Positron Emission Tomography in patients with GI stromal tumors or genotyping of c-kit in chronic myelogenous leukemia cells can guide the use of imatinib, these scenarios represent a minority of patients. The promise of individualized therapy, however, has led to the commercialization of numerous assays to probe patient's genetic make-up and that of the tumor. Breast cancer management has benefitted from the analysis of gene recurrence scores. More recently the analysis of germline or tumor-associated mutations in non-small cell lung cancer and melanoma has led to clinically meaningful molecular subsets of these diseases, guiding the successful targeting of such cancers with small-molecule inhibitors. Despite the high incidence of colorectal cancer and our relatively long-standing grasp of the molecular pathways in colorectal carcinogenesis, the management of these patients remains mostly empiric and movement toward “personalization” has been slow and incremental. Now, however, molecular imaging and commercial assays for genetic makeup of tumor specimens has put the oncologist and oncologic surgeon in the crossfire with patients and families who believe the era of “personalization” is here.
An overview of Monascus fermentation processes for monacolin K production
Authors: Wen Qinyou , Cao Xiaohua , Chen Zhiting , Xiong Zixiao , Liu Jianghong , Cheng Zuxin , Zheng Zhenghuai , Long Chuannan , Zheng Baodong , Huang Zhiwei 
Published: February 2020

AbstractIn Asia, Monascus has been used in food fermentation for nearly a thousand years. It has attracted increasing attention in recent years due to its ability to produce a variety of important active substances such as monacolin K (MK) and pigments. MK is an effective drug widely used for lowering human blood cholesterol that functions by inhibiting the rate-limiting enzyme in cholesterol biosynthesis. Monascus strains, fermentation methods and fermentation conditions have significant effects on MK yield, and much research has been undertaken to obtain higher MK yields. In this paper, the research progress of Monascus strain breeding for high MK yield, medium optimization for MK production during Monascus fermentation, and optimization of fermentation process conditions are fully reviewed. This provides reference for future research on Monascus fermentation and industrial production for high-yield MK production.
Like-minded and cross-cutting talk, network characteristics, and political participation online and offline: A panel study
Authors: Matthes Jörg , Marquart Franziska , Sikorski Christian von 
Published: February 2020

Abstract
We test the role of like-minded and cross-cutting political discussion as a facilitator of online and offline political participation and examine the role of strong versus weak network ties. Most prior research on the topic has employed cross-sectional designs that may lead to spurious relationships due to the lack of controlled variables. The findings of a two-wave panel survey controlling the autoregressive effects suggest that cross-cutting talk with weak ties significantly dampens online but not offline political participation. However, no such effects were detectable for cross-cutting talk with strong ties. In addition, we found no effect of discussions involving like-minded individuals in either weak or strong network connections on online and offline forms of political engagement. Implications are discussed.
Paraphrase or parasite?
Authors: Gorlée Dinda L. 
Published: February 2020

AbstractTranslation, for Saussure, assumed the codified rule of language respecting the difference between synchronic and diachronic linguistics. Translation may be regarded as a theoretical possibility, though impossible for the creative speech of language speakers. Peirce’s logical semiotics reasoned the linguistic-and-cultural (linguïcultural) interpretants of received signs. Semiotranslation is a semiotic game to change the symbiosis of two languages into one language. Identified with both Saussure and Peirce, Jakobson’s intralingual, interlingual, and intersemiotic forms of translation propose rewording, translation proper, and transmutation. Peirce’s semiosis creates simple and complex symbols but navigates between translation, semiotranslation, and transduction. Translation derives from thepara-functions of replicas in “paraphrase” and “parasite” to signify the multiplicity of ideas and trends in biotranslation. The source text can be re-organized into the iconic activity of Saussurean paraphrase; or the target text can be indexically recontextualized in the parasitical evolution of Peirce’s instinct and facts of life applied to arts — neither approaching pure science.
Spectral properties of certain Moran measures with consecutive and collinear digit sets
Authors: Wu Hai-Hua , Li Yu-Min , Dong Xin-Han 
Published: February 2020

Abstract
Let the

2
×
2

{2\times 2}

expanding matrix

R
k

{R_{k}}

be an integer Jordan matrix, i.e.,

R
k

=

diag
⁡

(

r
k

,

s
k

)

{R_{k}=\operatorname{diag}(r_{k},s_{k})}

or

R
k

=

J
⁢

(

p
k

)

{R_{k}=J(p_{k})}

, and let

D
k

=

{
0
,
1
,
…
,

q
k

-
1

}

⁢
v

{D_{k}=\{0,1,\ldots,q_{k}-1\}v}

with

v
=

(
1
,
1
)

T

{v=(1,1)^{T}}

and

2
≤

q
k

≤

p
k

,

r
k

,

s
k

{2\leq q_{k}\leq p_{k},r_{k},s_{k}}

for each natural number k.
We show that the sequence of Hadamard triples

{

(

R
k

,

D
k

,

C
k

)

}

{\{(R_{k},D_{k},C_{k})\}}

admits a spectrum of the associated Moran measure provided that

lim inf

k
→
∞

⁡

2
⁢

q
k

⁢

∥

R
k

-
1

∥

<
1

{\liminf_{k\to\infty}2q_{k}\lVert R_{k}^{-1}\rVert<1}

.
The effect of Islamic semanticism on self-reporting and lifestyles of mothers of adolescents with thalassemia
Authors: Yolme Aman Bibi Soltani , Hojjati Hamid , Akhoundzadeh Golbahar 
Published: February 2020

Abstract

Background
Thalassemia is the most common chronic hereditary disease in the world.

Objectives
The purpose of this study was to determine the effect of logotherapy on the level of resilience of mothers of children with thalassemia major.

Methods
The statistical population of this study included all mothers with children with thalassemia major in Gonbad-e-Qabus. After selecting eligible samples, each sample was given a number and the number was put into a non-transparent envelope. The samples were assured that numbering and placement in one of two groups were completely random and 60 mothers were selected using available sampling. The research tool used was the Kollahen Brief Self-reporting Questionnaire. For the experimental group, eight sessions of 90 min of logotherapy training were performed. For both groups, pre-test and post-test were performed. The confidentiality of the data of the research samples was assured. Data were gathered. Finally, the information was analyzed using SPSS software version 16.

Results
The results showed that the mean of the resilience of the experimental group was 28/16 ± 8/63 in the pre-test to was 24/76 ± 6/4 in the post-test. The result of paired t-test analysis showed that after eliminating the effect of the pre-test, the mean scores of the post-test of the two groups were statistically significant (p < 0/01, t = 18/4).

Conclusion
This study shows that logotherapy for mothers with children with thalassemia is useful and it is effective in increasing the resilience of mothers.
A memetic exploration of court interpretation
Authors: Li Jian , Ye Ning , Wagner Anne 
Published: February 2020

Abstract
Court interpretation subsumes transferring information from one source culture to the target culture, and the transfer of information, from the perspective of memetics, leads to the conceptualization of a common and significant framework in legal discourse, especially in the translation, interpretation and communication fields. This consideration gives the theoretical assumption for court interpretation, that is, court interpretation is a bilingual practice of meaning construction beyond meaning replication, because meaning units could be viewed as self-replicating complex ideas. Since the purpose of court interpretation is to find equivalence and the functions of court interpreters are being fair, semiotic equivalence can provide an even more useful tool for interpreters by offering greater insight into the mechanism of meaning and its encoding with the help of linguistic symbols. Meanwhile, court interpreters act as language and culture mediators to convey the correct contents of utterances and/or speech acts among their communities. Active and collaborative works are then necessary to mediate, decide, and analyze under real constraints with cultural challenges to elaborate viable interpretation solutions in laws.
Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2
Authors: Wihastuti Titin Andri , Amiruddin Reyhan , Cesa Fibe Yulinda , Alkaf Amalia Istiqamah , Setiawan Meddy , Heriansyah Teuku 
Published: February 2020

Abstract

Background
Type 2 diabetes mellitus (T2DM) is a major risk factor of atherosclerosis. Hyperglycemia in T2DM causes advanced formation of glycation end products (AGE) which leads to oxidative stress and chronic inflammation. Oxidative stress occurs due to increased levels of reactive oxygen species (ROS) such as H2O2. On the other hand, lipoprotein-associated phospholipase (Lp-PLA2) has pro-inflammatory effects, which cause instability of atherosclerosis plaques. This condition causes hypoxemic cells to stimulate HIFα induced vasa vasorum angiogenesis. This study aims to understand the potential of PSP as an anti-angiogenic agent through decreased levels of H2O2 and Lp-PLA2 leading to the decline of vasa vasorum angiogenesis in diabetic rat model. In addition, this study also measured the lipid profile of diabetic rat model in relation to vasa vasorum angiogenesis.

Methods
True laboratory experiment with randomized post-test control of group design using 25 wistar rats (Rattus norvegicus) were divided into five groups; one normal group and four group with High Fat Diet (HFD) and low dose streptozotocin (30 mg/kgBW) injection sc, treated with placebo and three various doses of PSP 50, 150, 300 mg/kgBW.

Results
ANOVA test (p < 0.05) shows that there is a significant influence of polysaccharide peptide (PSP) feeding on the decreased amount of vasa vasorum angiogenesis (p = 0.00), lipid profile (cholesterol total and triglyceride; p = 0.01, p = 0.001), and amount of H202 (p = 0.003). The amount of Lp-PLA2 declined to (p = 0.184). This result indicates that PSP prevents inflammation in atherosclerosis.

Conclusions
PSP of Ganoderma lucidum is an anti-angiogenic agent in T2DM.
Prenatal findings, neonatal symptoms and neurodevelopmental outcome of congenital cytomegalovirus infection in a university hospital in Montreal, Quebec
Authors: Minsart Anne-Frédérique , Rypens Françoise , Smiljkovic Mina , Kakkar Fatima , Renaud Christian , Lamarre Valérie , Boucher Marc , Boucoiran Isabelle 
Published: February 2020

AbstractBackgroundOutcome of congenital cytomegalovirus (cCMV) infection in the absence of routine CMV screening and third-trimester scan in North America is scarcely documented. The aim of this study was to assess the severe outcomes related to cCMV according to the indication for screening.MethodsThis was a retrospective study of 84 mother-child pairs followed for cCMV between 2003 and 2017 at CHU Sainte-Justine in Montreal, Canada. Prenatal ultrasound, neonatal symptoms, neuroimaging and severe outcomes (cerebral palsy, severe cognitive impairment, bilateral hearing loss or neonatal death) were reviewed.ResultsAmong 38 cases with abnormal prenatal ultrasound, 41.9% of live-born infants developed severe outcomes. Sixteen (42.1%) were detected in the third trimester. Among 16 cases diagnosed prenatally because of maternal history, all had normal prenatal ultrasound, and none developed severe outcomes. Among cases diagnosed postnatally because of neonatal symptoms, 25% developed severe outcomes. All infants who developed severe outcomes had moderate/severe neonatal symptoms.ConclusionOutcome of cCMV infection varies according to the reason for screening and timing of diagnosis. Any prenatal ultrasound anomaly might indicate a risk of severe outcome, and warrants a detailed ultrasound scan. However, late detection, or postnatal diagnosis, represented more than half of the cases, and awareness of this will help ensuring optimal management.
Crystal structure of (E)-3-(2-(2-hydroxy-4-methoxystyryl)-3,3-dimethyl-3H-indol-1-ium-1-yl)propane-1-sulfonate monohydrate, C22H25NO5S⋅H2O
Authors: Yu Qing , Zhang Qi-Long , Xu Hong , Huang Ya-Li 
Published: February 2020

Abstract
C22H25NO5S⋅H2O, triclinic, P1̄ (no. 2), a = 8.8121(4) Å, b = 10.6053(4) Å, c = 12.7365(5) Å, α = 80.943(2)°, β = 70.890(2)°, γ = 78.105(2)°, V = 1095.33(8) Å3, Z = 2, R
gt(F) = 0.0378, wR
ref(F
2) = 0.0949, T = 302(2) K.
Non-wood fibers as raw material for pulp and paper industry
Authors: Abd El-Sayed Essam S. , El-Sakhawy Mohamed , El-Sakhawy Mohamed Abdel-Monem 
Published: February 2020

AbstractPulp and paper industry in the world have been growing fast. As a result, there has been a massive request for pulp and paper raw materials. The raw materials used in papermaking can be classified into three groups: wood, non-wood, and recycled wastepaper. The Non-wood raw material is an important fiber resource in the regions where forest resources are limited. The current usage of non-wood plant fibers, as rice straws, corn stalks, cotton stalks, and bagasse would play a chief role in increasing papermaking raw materials. Using of non-wood plant fibers in the paper industry associated with some problems, including collection, transportation, storage and handling, washing, bleaching, papermaking, chemical recovery, supply of raw material and the properties of finished paper. Recently, a high-tech innovation in all the fields of papermaking has made non-wood more reasonable with wood as a raw material for papermaking. Although till now, use of non-wood fibers for pulp and paper manufacture was focused in countries with limited wood supply, it is now showing a growing effort even in countries with acceptable wood source due to environmental concerns. Consequently, the future of non-wood plant fibers as pulping and papermaking raw material looks bright.
Predicting inkjet dot spreading and print through from liquid penetration- and picoliter contact angle measurement
Authors: Krainer Sarah , Saes Louis , Hirn Ulrich 
Published: February 2020

AbstractIn this study we have evaluated the suitability of laboratory testing methods to predict inkjet printing results. We have developed and used testing liquids that are spanning the operational window of industrial High Speed Inkjet (HSI) printers while still covering the maximum possible range of viscosity and surface tension. First we correlated liquid penetration measured with ultrasound (ULP) and direct absorption (ASA) to print through from HSI prints. The best correlation (R2≈0.7{R^{2}}\approx 0.7) was found for the sized paper. For papers with increasing liquid penetration speed we found a decreasing ability of both testing methods to predict print through, for the strong absorbing paper the correlation drops toR2≈0.2{R^{2}}\approx 0.2. Second we correlated contact angle and drop diameter to the dot area from HSI prints. Contact angle turned out to be a better predictor for printed dot area than drop diameter. Evaluating the change in contact angle over time we found the highest correlation to the dot area in the print when measuring the contact angle as soon as possible, in our case 1 ms after deposition of the drop on the paper. We also compared contact angle with microliter drops to picoliter drops, which are in the size scale of the actual inkjet droplet. To our great surprise correlations for microliter drops were equal or better than for picoliter drops, particularly for highly absorbing papers. Thus in order to predict dot spreading on paper our results suggest to measure the contact angle with microliter drops. Overall we found that, using laboratory testing methods, print through and dot spreading for HSI printing can be quite well predicted for slow absorbing papers but not very well for fast absorbing papers.
Improved Muscle Strength, Muscle Power, and Physical Function After Flywheel Resistance Training in Healthy Older Adults: A Randomized Controlled Trial
Authors: Sañudo Borja , de Hoyo Moisés , McVeigh Joseph G. 
Published: February 2020

Abstract
Sañudo, B, de Hoyo, M, and McVeigh, JG. Improved muscle strength, muscle power, and physical function after flywheel resistance training in healthy older adults: A randomized controlled trial. J Strength Cond Res 36(1): 252–258, 2022—This study aimed to examine whether flywheel resistance exercise training improved muscle strength, muscle power, and physical function in older adults. Thirty-six older adults (64 ± 5 years) were randomly allocated to either a flywheel resistance exercise training group (ETG; n = 18) or a control (CON) group (n = 18). Subjects in the ETG underwent 6 weeks of resistance training on a flywheel squat device (4 sets of 9 maximal repetitions). Isokinetic concentric (60 and 240°·s−1) and eccentric (120°·s−1) knee extension and flexion peak torques and mean power were measured. Physical function was assessed by the 30-second Chair Sit-Stand Test (CST) and walking speed. After the intervention, within-group analyses showed significantly greater flexion torques and mean power with the dominant leg (concentric at 60°·s−1 and 240°·s−1 and eccentric at 120°·s−1; all d > 0.7, p < 0.05) and improvements in CST (d > 0.8) in the ETG, while no substantial differences were found in the CON group. Significant between-group differences in knee flexion torque both concentric (at 60°·s−1: η2 = 0.168 and 240°·s−1: η2 = 0.112) and eccentric (at 120°·s−1: η2 = 0.103) with the dominant leg were also found in favor of the ETG. There was also significantly better performance in the CST for the ETG (η2 = 0.207). There was a significant association between changes in strength and changes in mean power in the ETG. Changes in physical function outcomes were also observed. In conclusion, flywheel resistance exercise training is an appropriate form of activity for improving strength and functional capacity of older adults.
Key Anthropometric Variables Associated With Front-Crawl Swimming Performance in Youth Swimmers: An Allometric Approach
Authors: Sammoud Senda , Negra Yassine , Chaabene Helmi , Bouguezzi Raja , Attia Ahmed , Granacher Urs , Younes Hachana , Nevill Alan M. 
Published: February 2020

Abstract
Sammoud, S, Negra, Y, Chaabene, H, Bouguezzi, R, Attia, A, Granacher, U, Younes, H, and Nevill, AM. Key anthropometric variables associated with front-crawl swimming performance in youth swimmers: an allometric approach. J Strength Cond Res 37(6): 1259–1263, 2023—This study aimed to establish key anthropometric characteristics (e.g., optimal body height, limb-segment length, and girth/breadth ratios) related to 100-m front-crawl performance in young swimmers. In total, 74 swimmers (boys [n = 41; age: 18.1 ± 3.5 years]; girls [n = 33; age: 15.9 ± 3.1 years]) participated in this study. We adopted a multiplicative allometric log-linear regression model to identify key anthropometric characteristics associated with 100-m front-crawl swimming performance. The main outcomes indicated that length ratio = ([height/leg length]), foot length and ankle girth, biacromial breadth, and % of body fat were associated with 100-m front-crawl mean swimming speed performance. These findings highlight the importance of assessing anthropometric characteristics in young front-crawl swimmers for talent identification and development.
Perceived stress and resilience and their relationship with the use of mobile phone among nursing students
Authors: Sahu Maya , Gandhi Sailaxmi , Sharma Manoj Kumar , Marimuthu P. 
Published: February 2020

Objective. The study sought to explore the relationship between levels of stress and resilience with the use of the mobile phone in nursing students. Methods. Cross-sectional study conducted with 102 nursing students from several Nursing schools in India who were invited to participate in the research. The data were gathered by using the following instruments: Perceived Stress Scale(PSS) by Cohen, The Connor-Davidson Resilience scale (CD-RISC), and Mobile Phone Involvement Questionnaire(MPIQ)by Walsh. Results. Most of the participants were women (94.1%), studying in the undergraduate (70.6%), with a mean age of 25.2 years. In all, 77.5% of the students had stress perception between moderate and high, 20.6% had high resilience capacity, and 25.5% were frequent mobile phone users. Perceived stress was correlated significantly and negatively with age and resilience capacity. Graduate students had greater capacity to recover than undergraduate students. Conclusion. This study indicates the negative relation of resilience capacity with stress and the use of mobile phones among nursing students. Hence, it is necessary for institutions preparing nurses to develop intervention strategies to enhance the resilience capacity, improve skills to manage stress, and healthy use of the mobile phone.Descriptors: stress, physiological; resilience, psychological; students, nursing; cell phone use; cross-sectional studies; surveys and questionnaires.How to cite this article: Sahu M, Gandhi S, Sharma MK, Marimuthu P. Perceived stress and resilience and their relationship with the use of mobile phone among nursing students. Invest. Educ. Enferm. 2019; 37(3):e05.
Experience Lived by Iranian Patients with Irritable Bowel Syndrome: Transitory Crisis and Liberation
Authors: Mohebbi Zinat , Sharif Farkhondeh , Peyrovi Hamid , Rakhshan Mahnaz , Naini Mahvash Alizade , Zarshenas Ladan 
Published: February 2020

Objective. Research on the nature of living with Irritable Bowel Syndrome. Methods. Qualitative study of the hermeneutical phenomenology, which conducted in-depth semi-structured interviews with people trained on the irritable bowel syndrome. The sampling was intentional type and open questions were used to collect data. The Thematic Analysis Method by Van Manen was used. Results. Two principal themes and five subthemes emerged in this research to determine the meaning of living with the irritable bowel syndrome: Storm in corporality (body with pain and affliction, tension and sequence of symptoms, and: distress during moments of life) and Relief (sense of liberation of the body symptoms, and moments with pleasure). Conclusion. The experience lived by patients with irritable bowel syndrome is of a transitory crisis and liberation.Descriptors: irritable bowel síndrome; qualitative research; hermeneutics.How to cite this article: Mohebbi Z, Sharif F, Peyrovi H, Rakhshan M, Naini MA, Zarshenas L. Experience Lived by Iranian Patients with Irritable Bowel Syndrome: Transitory Crisis and Liberation. Invest. Educ. Enferm. 2019; 37(3):e10.