bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are temporomandibular disorders associated with facial asymmetry? A systematic review and meta‐analysis
Authors: Marques Fernanda Blaudt Carvalho , de Lima Lílian Siqueira , Oliveira Pedro Lima Emmerich , Magno Marcela Baraúna , Ferreira Daniele Masterson Tavares P. , de Castro Amanda Cunha Regal , Maciel Jose Vinicius Bolognesi , Ruellas Antonio Carlos de Oliveira , Maia Lucianne Copple 
Published: July 2020

AbstractObjectiveTo assess scientific evidence of the association between temporomandibular joint (TMJ) disorders and facial asymmetry (FA).MethodsA systematic review was performed in accordance with the PRISMA checklist. A search strategy was developed in electronic databases including MEDLINE, Scopus, Web of Science, Virtual Health Library and Cochrane Library until January 2020. Eligibility criteria included observational studies that investigated the occurrence of FA among patients with and without signs and symptoms of TMJ disorders. Risk of bias of individual studies was analysed after study selection and data collection processes according to Fowkes and Fulton guidelines. Four meta‐analyses (MA) were performed to evaluate the association between TMJ disorders and linear/angular menton deviation, subgrouping the studies into unilateral and bilateral cases. The evidence was certainty‐tested using the GRADE approach.ResultsThe search retrieved 2371 studies, 31 of which were eligible for full‐text reading. Seven cross‐sectional clinical studies met the eligibility criteria and were included in the qualitative synthesis, comprising a total of 621 subjects (345 with TMJ disease and 276 in control group), four of which were classified as being methodologically sound. Five studies were eligible for quantitative synthesis. Linear and angular menton deviation was greater in individuals with unilateral TMJ disorders than controls (MD = 2.41 [0.33, 4.50] P = .02; I2 = 86% and MD = 2.68 [0.99, 4.38] P = .002; I2 = 0%, respectively).ConclusionsDespite the low certainty in evidence, the present study indicated that unilateral TMJ disorders are associated with FA. However, longitudinal studies with greater certainty of evidence should be conducted to achieve a stronger estimate of this association.
Prognostic importance of RUNX1 expression for head and neck adenoid cystic carcinoma
Authors: Soares Ciro Dantas , de Cáceres Cinthia Veronica Bardález López , Rodrigues‐Fernandes Carla Isabelly , de Lima Morais Thayná Melo , de Almeida Oslei Paes , de Carvalho Maria Goretti Freire , Fonseca Felipe Paiva 
Published: July 2020

AbstractObjectiveIn the present study, we aimed to investigate the prognostic value of RUNX1 expression in 76 patients with adenoid cystic carcinoma (ACC).Materials and MethodsAll cases were arranged in tissue microarray blocks and submitted to immunohistochemistry against RUNX1. These results were statistically correlated with clinicopathologic features, including age, gender, tumour site, tumour size, lymph node status, AJCC clinical stage, distant metastasis, treatment, recurrences, follow‐up, histologic pattern, vascular and neural invasion, all of which obtained from patient's medical records.ResultsRUNX1 was expressed in the nuclei of tumour cells, with a mean of 18.1% of positivity. Nuclear RUNX1 expression was significantly associated with AJCC clinical stage (p < .0001), solid histologic pattern (p < .0001), vascular invasion (p < .0001) and presence of local recurrence (p < .0001). Using univariate and multivariate analyses, RUNX1 nuclear expression was significantly associated with a lower disease‐free survival (p < .0001 and p = .028, respectively) and disease‐specific survival (p < .0001 and p = .018, respectively) rates.ConclusionIn summary, RUNX1 nuclear expression may represent an indicator of unfavourable outcome for patients affected by head and neck ACC.
Pineal volume reduction in patients with mild cognitive impairment who converted to Alzheimer's disease
Authors: Matsuoka Teruyuki , Oya Nozomu , Yokota Hajime , Akazawa Kentaro , Yamada Kei , Narumoto Jin ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: July 2020

AimPineal parenchymal volume (PPV) reduction is one of the predisposing factors for Alzheimer's disease (AD). Therefore, PPV could be used as a predictor of developing AD in clinical settings. We investigated whether PPV in patients with mild cognitive impairment (MCI) was correlated with conversion of these patients to AD.MethodsA total of 237 patients with MCI underwent brain magnetic resonance imaging. A two‐samplet‐test was used to compare PPV at baseline in MCI patients who converted to AD (MCI‐C) with those who did not convert (MCI‐NC). Logistic regression analysis with forced entry was used to identify predictors of AD, with variables of PPV, age, sex, education, APOE‐ε4 alleles, Mini Mental State Examination score, and total intracranial volume at baseline. Two‐way repeated‐measures analysis of variance was conducted to compare PPV at baseline and at the last examination in the MCI‐C and MCI‐NC groups.ResultsPPV in the MCI‐C group was significantly lower than that in the MCI‐NC group. In logistic regression analysis, two independent predictors of AD were identified: Mini Mental State Examination and PPV. Two‐way repeated‐measures analysis of variance revealed a significant group effect, but no time effect.ConclusionThe pineal volume is a predictor of AD conversion, and pineal volume reduction in AD starts early when patients are still in the MCI stage. Thus, pineal volume reduction might be useful as a predictor of developing AD in clinical settings.
A cross‐sectional association of physical fitness with positive and negative affect in children and adolescents: the up & down study
Authors: del Río‐de Cózar Paula , Carbonell‐Baeza Ana , Padilla‐Moledo Carmen , Veiga Oscar L. , Esteban‐Gonzalo Laura , Mota Jorge , Castro‐Piñero José 
Published: July 2020

AbstractBackgroundAffect and physical fitness play an important role in psychological and physical health; however, the association between those variables in youth remains unknown. The aim of the present study was to examine the influence of physical fitness on positive and negative affect in Spanish children and adolescents.MethodHealthy young Spanish people (n = 1,490) were recruited for the present study: 542 children (n = 272 girls; mean age 9.6 years) and 948 adolescents (n = 454 girls; mean age 14.1 years) with complete baseline data on health‐related fitness tests (20 m shuttle run test, 4 × 10 m test, muscular fitness index, and physical fitness index), and positive and negative affect (Positive and Negative Affect Schedule).ResultsHigher performance on physical fitness components was associated with positive affect (β = −0.176–0.118, all P < 0.05). There was no association between all physical fitness components and negative affect (β = −0.100–0.15, all P > 0.05). There were differences on positive affect between the lowest and the highest quartile of the physical fitness index in boys (P = 0.037, Cohen's d 0.60) and girls (P = 0.004, Cohen's d = 0.69), and between the lowest and the highest quartile of muscular fitness index in girls (P < 0.001, Cohen's d = 0.76).ConclusionsPromoting physical activity during the school years, including strength exercises to increase muscular fitness, could improve positive affect levels and thus psychological health.
A WRKY transcription factor, TaWRKY40‐D, promotes leaf senescence associated with jasmonic acid and abscisic acid pathways in wheat
Authors: Zhao L. , Zhang W. , Song Q. , Xuan Y. , Li K. , Cheng L. , Qiao H. , Wang G. , Zhou C. 
Published: July 2020

Abstract

Leaf senescence is a complex and precise regulatory process that is correlated with numerous internal and environmental factors. Leaf senescence is tightly related to the redistribution of nutrients, which significantly affects productivity and quality, especially in crops. Evidence shows that the mediation of transcriptional regulation by WRKY transcription factors is vital for the fine‐tuning of leaf senescence. However, the underlying mechanisms of the involvement of WRKY in leaf senescence are still unclear in wheat.

Using RNA sequencing data, we isolated a novel WRKY transcription factor, TaWRKY40‐D, which localizes in the nucleus and is basically induced by the progression of leaf senescence.

TaWRKY40‐D is a promoter of natural and dark‐induced leaf senescence in transgenic Arabidopsis thaliana and wheat. We also demonstrated a positive response of TaWRKY40‐D in wheat upon jasmonic acid (JA) and abscisic acid (ABA) treatment. Consistent with this, the detached leaves of TaWRKY40‐D VIGS (virus‐induced gene silencing) wheat plants showed a stay‐green phenotype, while TaWRKY40‐D overexpressing Arabidopsis plants showed premature leaf senescence after JA and ABA treatment. Moreover, our results revealed that TaWRKY40‐D positively regulates leaf senescence, possibly by altering the biosynthesis and signalling of JA and ABA pathway genes.

Together, our results suggest a new regulator of JA‐ and ABA‐related leaf senescence, as well as a new candidate gene that can be used for molecular breeding in wheat.
Relative economic status and mental health among Chinese adults: Evidence from the China health and retirement longitudinal study
Authors: Zhou Qin , Qin Xuezheng , Liu Gordon G. 
Published: July 2020

AbstractRecent research documents increasing unhappiness (even depression) among Chinese adults despite the rapid economic growth in China. This paper explains this discrepancy by exploring the relationship between relative economic status and mental health (measured by Center for Epidemiologic Studies Depression Scale score) among the middle‐aged and elderly in China. In measuring relative economic status, we use five reference groups for comparison (i.e., relatives, colleagues, schoolmates, neighbors or villagers, and people in the same city or county). Using data from 2013 China Health and Retirement Longitudinal Study, we find that individuals with relatively lower economic status are more likely to be mentally depressed. The relationship differs across reference groups for comparisons, with the larger impacts seen from the comparison against acquaintances, while the impact of comparison to regional average is the smallest despite its frequent use in the literature. The relative economic status–mental health gradient is asymmetric; that is, the negative impact of worse relative economic status is comparatively larger and more significant than the positive impact of better relative economic status. Our results imply that reducing wealth gaps within groups of similar backgrounds can be more effective in improving people’s mental health than a general reduction of wealth inequality within the population.
Assessment of greywater reuse as a potential mitigation measure for water shortages and sanitation problems in senior high schools
Authors: Ntibrey Richard Agbo Kwabena , Fosu Gyasi Samuel , Kuranchie Francis Atta 
Published: July 2020

AbstractThe study assessed water shortages and its effects on sanitation in Senior High Schools using structured questionnaires involving water availability, water use pattern and perception of greywater reuse. Additionally, an observation of the sanitation situation was done to validate the responses. The study found that water availability was an issue as this caused students to use more than an hour round trip to access water resulting in poor sanitation and hygiene practices. Meanwhile, an average greywater generation rate of 14.5 L per person per day, is always disposed of despite its potential reuse. Greywater reuse was accepted by respondents as 59% proposed reusing it if available for non‐potable applications (94%) such as toilet cleaning and flushing. This is because, there is a significant association between cleanliness of the toilet facilities and usage (P < 0.05). Respondents who declined greywater reuse cited health risks (58%), uncomfortable feeling (37%) and cultural issue (5%).
Age‐related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells
Authors: Jeng Jing‐Yi , Johnson Stuart L. , Carlton Adam J , De Tomasi Lara , Goodyear Richard J. , De Faveri Francesca , Furness David N. , Wells Sara , Brown Steve D. M. , Holley Matthew C. , Richardson Guy P. , Mustapha Mirna , Bowl Michael R. , Marcotti Walter 
Published: July 2020

Key points
Age‐related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure).
Currently, we know very little about age‐related changes occurring in the auditory sensory cells, including those associated with the outer hair cells (OHCs).
Using different mouse strains, we show that OHCs undergo several morphological and biophysical changes in the ageing cochlea.
Ageing OHCs also exhibited the progressive loss of afferent and efferent synapses.
We also provide evidence that the size of the mechanoelectrical transducer current is reduced in ageing OHCs, highlighting its possible contribution in cochlear ageing.
AbstractOuter hair cells (OHCs) are electromotile sensory receptors that provide sound amplification within the mammalian cochlea. Although OHCs appear susceptible to ageing, the progression of the pathophysiological changes in these cells is still poorly understood. By using mouse strains with a different progression of hearing loss (C57BL/6J, C57BL/6NTac, C57BL/6NTacCdh23+, C3H/HeJ), we have identified morphological, physiological and molecular changes in ageing OHCs (9–12 kHz cochlear region). We show that by 6 months of age, OHCs from all strains underwent a reduction in surface area, which was not a sign of degeneration. Although the ageing OHCs retained a normal basolateral membrane protein profile, they showed a reduction in the size of the K+ current and non‐linear capacitance, a readout of prestin‐dependent electromotility. Despite these changes, OHCs have a normal Vm and retain the ability to amplify sound, as distortion product otoacoustic emission thresholds were not affected in aged, good‐hearing mice (C3H/HeJ, C57BL/6NTacCdh23+). The loss of afferent synapses was present in all strains at 15 months. The number of efferent synapses per OHCs, defined as postsynaptic SK2 puncta, was reduced in aged OHCs of all strains apart from C3H mice. Several of the identified changes occurred in aged OHCs from all mouse strains, thus representing a general trait in the pathophysiological progression of age‐related hearing loss, possibly aimed at preserving functionality. We have also shown that the mechanoelectrical transduction (MET) current from OHCs of mice harbouring the Cdh23ahl allele is reduced with age, highlighting the possibility that changes in the MET apparatus could play a role in cochlear ageing.
Alianzas público privadas en los servicios educativos en Colombia
Authors: Dueñas-Herrera Ximena , Godoy-Mateus Silvana , Duarte-Rodríguez Jorge Leonardo , Oquendo-Victoria Diana Alexandra , Campiño-Castillo Johnny Ernesto 
Published: July 2020

Las alianzas público privadas (APP) han sido reconocidas como una estrategia para aumentar la cobertura y calidad de la educación, sin embargo, su efectividad parece depender de la calidad de los contratos y del nivel de igilancia del Estado. En este artículo se analiza la relación entre los resultados del examen Saber 11 aplicado en Colombia en 2015 y el sector o modalidad de los colegios. Con base en modelos multinivel, se concluye que, entre los estudiantes con alta probabilidad de pertenecer al sector oficial, aquellos que asisten a colegios oficiales evidencian un mejor desempeño promedio.
The Influence of Internal Heat Storage Material and Longitudinal Fins on a Double-Pass Solar Air Heater Performance
Authors: Sivarathinamoorthy H. , Sureshkannan G. 
Published: July 2020

Abstract
This study presents the overall performance of a double-pass solar air heater (DPSAH) with three different configurations: (i) double-pass solar air heater without fins and heat storage (DPSAHWF), (ii) double-pass solar air heater with longitudinal fins and without heat storage (DPSAHLF), and (iii) double-pass solar air heater with longitudinal fins and heat storage (DPSAHLFHM). Five longitudinal fins on the upper channel and granular carbon at the bottom of lower channel as heat storage material were used for the analysis. Each configuration was examined for the following flowrates of air (ṁ1 = 0.008 kg/s, ṁ2 = 0.012 kg/s, and ṁ3 = 0.016 kg/s). The results show an improvement in thermal efficiency with an increase in the air flowrate. The outlet air temperature increases considerably with a decrease in flowrate, for all the three orientations. The lowest and the highest efficiencies during the peak sunshine hours were recorded as 33% and 65% for the conventional heater and the heater with fins and heat storage material, respectively. A maximum of 849 W/m2 of solar intensity was recorded during the test period. The system is also examined for thermal discharge after the sunshine hours to determine the effectiveness of the heat storage material.
Analysis of Designer Emotions in Collaborative and Traditional Computer-Aided Design
Authors: Zhou Jinxuan (Janice) , Phadnis Vrushank , Olechowski Alison 
Published: July 2020

Abstract
We developed a new method to link designer emotions with corresponding designer activities while using computer-aided design (cad) software. Our method employs automated facial emotion detection software and cursor tracking. We applied this method via an experiment with nine participants, each working with the same synchronously collaborative cad platform, and assigned a series of cad tasks in one of two distinct working styles: single participants working by themselves and paired participants working together. We analyzed and compared trends in emotion for these two working styles. Pairs, on average per person, experienced higher levels of emotion (measured as joy, sadness, anger, contempt, fear, and surprise) than individuals. We linked occurrences of each emotional response to their antecedent activities in the cad environment (navigating the model tree, sketching in the graphics area, making selections in the feature menu, and communicating using the chat window). Using a logistic regression analysis, we revealed statistically significant trends linking emotions and cad events, and we found that some emotions are more likely to occur with certain designer actions in the cad software. The method and conclusions presented in this paper allow us to better understand designer emotions in traditional and collaborative cad, which link to the established relationships between emotion and designer satisfaction, creativity, performance, and other outcomes increasingly valued by engineering designers and managers in virtually collaborative environments.
Online Data-Driven Prediction of Spatio-Temporal System Behavior Using High-Fidelity Simulations and Sparse Sensor Measurements
Authors: Zhao X. , Azarm S. , Balachandran B. 
Published: July 2020

AbstractPredicting the behavior or response for complicated dynamical systems during their operation may require high-fidelity and computationally costly simulations. Because of the high computational cost, such simulations are generally done offline. The offline simulation data can then be combined with sensors measurement data for online, operational prediction of the system's behavior. In this paper, a generic online data-driven approach is proposed for the prediction of spatio-temporal behavior of dynamical systems using their simulation data combined with sparse, noisy sensors measurement data. The approach relies on an offline–online approach and is based on an integration of dimension reduction, surrogate modeling, and data assimilation techniques. A step-by-step application of the proposed approach is demonstrated by a simple numerical example. The performance of the approach is also evaluated by a case study which involves predicting aeroelastic response of a joined-wing aircraft in which sensors are sparsely placed on its wing. Through this case study, it is shown that the results obtained from the proposed spatio-temporal prediction technique have comparable accuracy to those from the high-fidelity simulation, while at the same time significant reduction in computational expense is achieved. It is also shown that, for the case study, the proposed approach has a prediction accuracy that is relatively robust to the sensors’ locations.
Uncertainty Quantification of Mode Shape Variation Utilizing Multi-Level Multi-Response Gaussian Process
Authors: Zhou K. , Tang J. 
Published: July 2020

Abstract
Mode shape information plays the essential role in deciding the spatial pattern of vibratory response of a structure. The uncertainty quantification of mode shape, i.e., predicting mode shape variation when the structure is subjected to uncertainty, can provide guidance for robust design and control. Nevertheless, computational efficiency is a challenging issue. Direct Monte Carlo simulation is unlikely to be feasible especially for a complex structure with a large number of degrees-of-freedom. In this research, we develop a new probabilistic framework built upon the Gaussian process meta-modeling architecture to analyze mode shape variation. To expedite the generation of input data set for meta-model establishment, a multi-level strategy is adopted which can blend a large amount of low-fidelity data acquired from order-reduced analysis with a small amount of high-fidelity data produced by high-dimensional full finite element analysis. To take advantage of the intrinsic relation of spatial distribution of mode shape, a multi-response strategy is incorporated to predict mode shape variation at different locations simultaneously. These yield a multi-level, multi-response Gaussian process that can efficiently and accurately quantify the effect of structural uncertainty to mode shape variation. Comprehensive case studies are carried out for demonstration and validation.
Low-Frequency Acoustic Absorption of 3D Printed Cylinders
Authors: Slaboch Paul E. , Kaye Sophie , Casavant Ethan 
Published: July 2020

Abstract
Attenuating low-frequency sound is often problematic, due to the large space required for common absorptive materials to mitigate such noise. However, natural hollow reeds are known to effectively attenuate low frequencies while occupying relatively little space compared to traditional absorptive materials. The present study determines the effect of varied outer diameter and outer spacing on the 200–1600 Hz acoustic absorption of 3D printed arrays of hollow cylinders. Samples were tested in a 100-mm diameter normal incidence impedance tube such that cylinder length was oriented perpendicular to the incoming plane wave. By varying only one geometric element of each array, the absorption due to any parameter can be assessed individually. It was found that minimizing cylinder spacing and maximizing cylinder diameter resulted in increased overall absorption and produced more focused absorption peaks at specific low frequencies. Wider cylinder spacing produced a broader absorptive frequency range, despite shifting upward in frequency. Thus, manipulating these variables can specifically target absorption for low-frequency noise that would otherwise disturb listeners.