bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Extreme Rainfall Event of 7 May 2017 over the Coastal City of Guangzhou. Part I: Impacts of Urbanization and Orography
Authors: Yin Jinfang , Zhang Da-Lin , Luo Yali , Ma Ruoyun 
Published: January 2020

Abstract
In this study, a nocturnal extreme rainfall event induced by the urban heat island (UHI) effects of the coastal city of Guangzhou in South China on 7 May 2017 is examined using observational analyses and 18-h cloud-permitting simulations with the finest grid size of 1.33 km and the bottom boundary conditions nudged. Results show that the model reproduces convective initiation on Guangzhou’s downstream side (i.e., Huashan), where a shallow thermal mesolow is located, the subsequent back-building of convective cells as a larger-scale warm-moist southerly flow interacts with convectively generated cold outflows, and their eastward drifting and reorganization into a localized extreme-rain-producing storm near Jiulong under the influences of local orography. In particular, the model produces the maximum hourly, 3- and 12-hourly rainfall amounts of 146, 315, and 551 mm, respectively, at nearly the right location compared to their corresponding observed extreme amounts of 184, 382, and 542 mm. In addition, the model reproduces an intense meso-γ-scale vortex associated with the extreme-rain-producing Jiulong storm, as also captured by Doppler radar, with organized updrafts along cold outflow boundaries over a semicircle. A comparison of sensitivity and control simulations indicates that despite the occurrence of heavier rainfall amounts without the UHI effects than those without orography, the UHI effects appear to account directly for the convective initiation and heavy rainfall near Huashan, and indirectly for the subsequent formation of the Jiulong storm, while orography plays an important role in blocking cold outflows and enhancing cool pool strength for the sustained back-building of convective cells over the semicircle, thereby magnifying rainfall production near Jiulong.
Website Usability Differences between Males and Females: An Eye-Tracking Evaluation of a Climate Decision Support System
Authors: Maudlin Lindsay C. , McNeal Karen S. , Dinon-Aldridge Heather , Davis Corey , Boyles Ryan , Atkins Rachel M. 
Published: January 2020

ABSTRACTDecision support systems—collections of related information located in a central place to be used for decision-making—can be used as platforms from which climate information can be shared with decision-makers. Unfortunately, these tools are not often evaluated, meaning developers do not know how useful or usable their products are. In this study, a web-based climate decision support system (DSS) for foresters in the southeastern United States was evaluated by using eye-tracking technology. The initial study design was exploratory and focused on assessing usability concerns within the website. Results showed differences between male and female forestry experts in their eye-tracking behavior and in their success with completing tasks and answering questions related to the climate information presented in the DSS. A follow-up study, using undergraduate students from a large university in the southeastern United States, aimed to determine whether similar gender differences existed and could be detected and, if so, whether the cause(s) could be determined. The second evaluation, similar to the first, showed that males and females focused their attention on different aspects of the website; males focused more on the maps depicting climate information while females focused more on other aspects of the website (e.g., text, search bars, and color bars). DSS developers should consider the possibility of gender differences when designing a web-based DSS and include website features that draw user attention to important DSS elements to effectively support various populations of users.
Fatal and non-fatal health incidents related to recreational ecstasy use
Authors: van Amsterdam Jan , Pennings Ed , van den Brink Wim 
Published: January 2020

Background: The recreational drug ecstasy (3,4-methylenedioxymethamphetamine) is currently used world-wide. Severe (including fatal) health incidents related to ecstasy have been reported but a risk assessment of acute non-fatal and fatal ecstasy-related health incidents has never been performed. Methods: In the current risk assessment review, national data of non-fatal health incidents collected in the Netherlands were combined with the nationwide exposure to ecstasy, that is, last-year prevalence of ecstasy use. In addition, the annual number of ecstasy-related deaths in Great Britain (Scotland, Wales and England) was used to assess the risk of fatal ecstasy-related cases. Results: In the Netherlands, the estimated risk of a moderate to severe acute health incident following the use of ecstasy is one in 900 pills (0.11%), whereas for cocaine it is one in 1600 doses (0.06%) and for gamma-hydroxybutyrate one in 95 doses (1.05%). With respect to ecstasy-related deaths in Great Britain, the estimated risk of ecstasy alone per user is 0.01–0.06%, which is close to the range of the fatality risk in chronic alcohol users (0.01–0.02%), amphetamine users (0.005%) and cocaine users (0.05%), but much lower than that of opiate use (heroin and morphine: 0.35%). Conclusion: The current review shows that almost no data are available on the health risks of ecstasy use. The few data that are available show that ecstasy is not a safe substance. However, compared to opiates (heroin, morphine), the risk of acute ecstasy-related adverse health incidents per ecstasy user and per ecstasy use session is relatively low.
PROMIS Versus Legacy Patient-Reported Outcome Measures in Patients Undergoing Surgical Treatment for Symptomatic Acetabular Dysplasia
Authors: Li Deborah J. , Clohisy John C. , Schwabe Maria T. , Yanik Elizabeth L. , Pascual-Garrido Cecilia 
Published: January 2020

Background: No previous study has investigated how the Patient-Reported Outcomes Measurement Information System (PROMIS) performs compared with legacy patient-reported outcome measures in patients with symptomatic acetabular dysplasia treated with periacetabular osteotomy (PAO). Purpose: To (1) measure the strength of correlation between the PROMIS and legacy outcome measures and (2) assess floor and ceiling effects of the PROMIS and legacy outcome measures in patients treated with PAO for symptomatic acetabular dysplasia. Study Design: Cohort study (Diagnosis); Level of evidence, 2. Methods: This study included 220 patients who underwent PAO for the treatment of symptomatic acetabular dysplasia. Outcome measures included the Hip disability and Osteoarthritis Outcome Score (HOOS) pain, HOOS activities of daily living (ADL), modified Harris Hip Score (mHHS), PROMIS pain, and PROMIS physical function subsets, with scores collected preoperatively and/or postoperatively at a minimum 12-month follow-up. The change in mean scores from preoperatively to postoperatively was calculated only in a subgroup of 57 patients with scores at both time points. Distributions of the PROMIS and legacy scores were compared to evaluate floor and ceiling effects, and Pearson correlation coefficients were calculated to evaluate agreement. Results: The mean age at the time of surgery was 27.7 years, and 83.6% were female. The mean follow-up time was 1.5 years. Preoperatively, neither the PROMIS nor the legacy measures showed significant floor or ceiling effects. Postoperatively, all legacy measures showed significant ceiling effects, with 15% of patients with a maximum HOOS pain score of 100, 29% with a HOOS ADL score of 100, and 21% with an mHHS score of 100. The PROMIS and legacy instruments showed good agreement preoperatively and postoperatively. The PROMIS pain had a moderate to strong negative correlation with the HOOS pain ( r = −0.66; P < .0001) and mHHS ( r = −0.60; P < .0001) preoperatively and the HOOS pain ( r = −0.64; P < .0001) and mHHS ( r = −0.64; P < .0001) postoperatively. The PROMIS physical function had a moderate positive correlation with the HOOS ADL ( r = 0.51; P < .0001) and mHHS ( r = 0.49; P < .0001) preoperatively and a stronger correlation postoperatively with the HOOS ADL ( r = 0.56; P < .0001) and mHHS ( r = 0.56; P < .0001). Conclusion: We found good agreement between PROMIS and legacy scores preoperatively and postoperatively. PROMIS scores were largely normally distributed, demonstrating an expanded ability to capture variability in patients with improved outcomes after treatment.
Anterior Crossbite: Interceptive Orthodontics for Prevention, Maryland Bridges for Correction
Authors: Beard Gary B. 
Published: January 2020

Displacement of teeth (malocclusions) in companion animals becomes important when it results in occlusal traumas and tooth attrition, or soft tissue damage. These defects may be so minor that years elapse before they take their toll on oral health or they may be so major that mastication is impossible. This paper addresses the oral health aspects of veterinary dental orthodontics as it relates to anterior cross bite and interceptive orthodontics.
Negotiating Quality for Social Work: A Participatory Research Project in South Tyrol
Authors: Lorenz Walter A. , Fargion Silvia , Nothdurfter Urban , Nagy Andrea , Berger Elisabeth , Rainer Sylvia , Frei Sabina 
Published: January 2020

Purpose: The measurement of quality in social work practice has become an area of growing interest and relevance in the social services field. Our starting point is that quality in interventions with human beings has to be defined in ways that incorporate the multiple perspectives of all the subjects involved. Methods: The study, adopting qualitative and quantitative methods, explored issues of quality in social services provision in South Tyrol in Italy from the point of view of the main stakeholders. Results: It was possible to identify four dimensions of quality that stakeholders considered important: the political role of practitioners, the ability to take an active role in the organization, the capacity to connect with other professionals, and the quality of direct relationships with users. Conclusions: Results provide an understanding of the common and differing expectations evident in stakeholders’ perspectives and ideas for better quality systems
The association of anaemia and its severity with composite morbidity after total hip arthroplasty
Authors: Frangie Robert , Masrouha Karim Z , Abi-Melhem Racha , Tamim Hani , Al-Taki Muhyeddine 
Published: January 2020

Background: Total hip arthroplasty (THA) is a common orthopaedic procedure and is expected to increase with an increasing elderly population. Many of these patients suffer from chronic diseases which might be associated with anaemia. Anaemia, by itself, increases the risk of morbidity. We aimed to delineate relationship between preoperative anaemia and postoperative composite morbidities in patients undergoing primary THA. Methods: A cohort study analysed the data from the American College of Surgeons National Surgical Quality Improvement Program 2008–2014 database. Adult patients who underwent unilateral primary THA were included and divided into 3 groups: no anaemia, mild anaemia, and moderate-to-severe anaemia. Thirty-day mortality and morbidity were recorded as adverse events. The associations between anaemia, baseline characteristics, and adverse events were analysed after adjusting for confounders. Results: Moderate-to-severe anaemia patients were at increased risk for composite morbidity (adjusted odds ratio, 1.43 [1.17–1.74]) when compared to non-anaemics. The stratification revealed a significant effect of younger age, male gender, white race, obesity, general anaesthesia, and mean operative time >120 minutes in patients with moderate-to-severe anaemia. These patients were also at a higher risk of developing several specific morbidities. Conclusion: Moderate-to-severe anaemia increases the risk for composite morbidities, but not mortality in patients undergoing primary THA. Further studies are needed to assess whether preoperative management of moderate-to-severe anaemia would improve outcomes in patients undergoing THA.
Surgery for Renal Hyperparathyroidism in the Era of Cinacalcet: A Single-Center Experience
Authors: Mogl M. T. , Skachko T. , Dobrindt E. M. , Reinke P. , Bures C. , Pratschke J. , Rayes N. 
Published: January 2020

Background and Aims: There are only few data on the influence of cinacalcet on the outcome of parathyroidectomy in patients with renal hyperparathyroidism. Indication and timing of surgery have changed since its introduction, especially with regard to kidney transplantation. Therefore, we retrospectively analyzed patients undergoing parathyroidectomy for renal hyperparathyroidism in our institution. Material and methods: Between 2008 and 2015, 196 consecutive operations in 191 patients were analyzed. About 80 operations (41%) were performed in patients receiving cinacalcet compared with 116 operations (59%) in patients without cinacalcet. Clinical data, preoperative medication, pre- and postoperative laboratory values, type and details of surgery including complications, as well as cardiovascular complications and kidney transplantation with graft function were recorded. Results: Demographical data were similar in patients with or without cinacalcet treatment. A total of 54% of patients received a kidney graft before or after parathyroidectomy. Pre- and postoperative parathormone levels were similar in both groups (preoperatively 755 vs 742 ng/L, postoperatively 50 vs 46 ng/L, p > 0.10), whereas patients with cinacalcet showed significantly lower calcium levels preoperatively (2.28 vs 2.41 mmol/L, p = 0.0002). There was no difference in recurrence or persistence of hyperparathyroidism, duration of surgery, hospital stay, or complication rate. Creatinine levels in patients with tertiary hyperparathyroidism were similar after 1-year follow-up. Conclusion: Cinacalcet did not influence outcome of patients with parathyroidectomy for renal hyperparathyroidism and can be safely offered to patients not responding to medical treatment.
A Critical Analysis of Education for Sustainability in Early Childhood Curriculum Documents in China and Norway
Authors: Li Minyi , Zhang Yulin , Yuan Lehan , Birkeland Åsta 
Published: January 2020

Purpose: This article examines how early childhood curriculum documents in two culturally different contexts are associated with current concepts of sustainability and principles of early childhood education for sustainability (ECEfS) in China and Norway. Design/Approach/Methods: Applying critical document analysis, the study explores a number of landmark curriculum documents from China and Norway, comparing the ways in which ECEfS is conceptualized, including the concept of sustainability, children as agents of change for sustainability, and sustainability in young children’s everyday lives. Findings: Corresponding to the analytical framework, China and Norway attach different importance to the three dimensions of sustainability—social-cultural, economic, and environmental. For example, Norway has a more autonomous view of children’s agency, while China gives more emphasis to teachers’ support. The two countries also have different perspectives on how to work with families and communities based on significantly different traditions and institutions. The comparative document analysis argues that predominant cultural dimensions in each context, such as collectivist and individualistic factors, may shape the understandings of sustainability in each country’s early years’ curriculum documents. Originality/Values: By broadening the focus on the social-cultural aspects of sustainability, this study extends the development of a culturally inclusive understanding of the concept of sustainability and contextualized/localized approaches to ECEfS across the globe.
Effect of sedation anesthesia on kinesiophobia and early outcomes after total knee arthroplasty
Authors: Degirmenci Erdem , Ozturan Kutay Engin , Kaya Yasin Emre , Akkaya Akcan , Yucel İstemi 
Published: January 2020

Background: Total knee arthroplasty (TKA) operation is an effective treatment method in severe osteoarthritis worldwide. However, the number of patients with chronic pain and functional limitations in the postoperative period will continue to increase. Kinesiphobia is an important factor that affects the functional outcomes postoperatively. The aim of this study is to investigate the effects of intraoperative consciousness of the patients during surgery on kinesiophobia development and early functional outcomes of TKA. Methods: Sixty patients with the diagnosis of primary knee osteoarthritis were enrolled in the study. Tampa Scale of Kinesiophabia (TSK) was obtained for each patient at multiple time periods. Regional anaesthesia and deep sedation were performed on group 1 ( n = 30), while regional anaesthesia and light sedation were performed on group 2 ( n = 30). The same surgical procedures were applied to all participants. Functional tests were performed on the patients at the postoperative 2nd and 5th days. Visual Analogue Scale (VAS) scores and knee flexion angles were also measured postoperatively. Results: The mean age of the participants (19 men (31.7%) and 41women (68.3%)) was 67.7 ± 6.7 (54–82) years. TSK ≥ 40 was detected in 18 (30%) patients preoperatively and 33 patients (55%) postoperatively. The number of kinesiophobic patients showed statistically significant increase after operation (20/30 (66.7%)) according to preoperative period (9/30 (30%)) in group 2 ( p = 0.003). Postoperative functional scores, knee flexion angles and VAS scores were better in non-kinesiophobic patients. Conclusion: Patient’s consciousness during TKA operations is an important factor that interferes with the postoperative kinesiophobia development, which may play a pivotal role affecting the early mobility and functional outcomes.
ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura
Authors: Göbel Carl H. , Karstedt Sarah C. , Münte Thomas F. , Göbel Hartmut , Wolfrum Sebastian , Lebedeva Elena R. , Olesen Jes , Royl Georg 
Published: January 2020

Abstract
Background
In the emergency room, distinguishing between a migraine with aura and a transient ischemic attack (TIA) is often not straightforward and mistakes can be harmful to both the patient and to society. To account for this difficulty, the third edition of the International Classification of Headache disorders (ICHD-3) changed the diagnostic criteria of migraine with aura.

Methods
One hundred twenty-eight patients referred to the emergency room at the University Hospital of Lübeck, Germany with a suspected TIA were prospectively interviewed about their symptoms leading to admission shortly after initial presentation. The diagnosis that resulted from applying the ICHD-3 and ICHD-3 beta diagnostic criteria was compared to the diagnosis made independently by the treating physicians performing the usual diagnostic work-up.

Results
The new ICHD-3 diagnostic criteria for migraine with aura and migraine with typical aura display an excellent specificity (96 and 98% respectively), and are significantly more specific than the previous ICHD-3 beta classification system when it comes to diagnosing a first single attack (probable migraine with aura and probable migraine with typical aura).

Conclusions
The ICHD-3 is a highly useful tool for the clinical neurologist in order to distinguish between a migraine with aura and a TIA, already at the first point of patient contact, such as in the emergency department or a TIA clinic.
Anti-masculinization induced by aromatase inhibitors in adult female zebrafish
Authors: Chen Lu , Wang Li , Cheng Qiwei , Tu Yi-Xuan , Yang Zhuang , Li Run-Ze , Luo Zhi-Hui , Chen Zhen-Xia 
Published: January 2020

AbstractBackgroundEarly sex differentiation genes of zebrafish remain an unsolved mystery due to the difficulty to distinguish the sex of juvenile zebrafish. However, aromatase inhibitors (AIs) could direct juvenile zebrafish sex differentiation to male and even induce ovary-to-testis reversal in adult zebrafish.ResultsIn order to determine the transcriptomic changes of sex differentiation in juvenile zebrafish and early sex-reversal in adult zebrafish, we sequenced the transcriptomes of juvenile and adult zebrafish treated with AI exemestane (EM) for 32 days, when juvenile zebrafish sex differentiation finished. EM treatment in females up-regulated the expression of genes involved in estrogen metabolic process, female gamete generation and oogenesis, includinggsdf,macf1aandpaqr5a, while down-regulated the expression of vitellogenin (vtg) genes, includingvtg6,vtg2,vtg4, andvtg7due to the lower level of Estradiol (E2). Furthermore, EM-juveniles showed up-regulation in genes related to cell death and apoptosis, such asbcl2l16andanax1c,while the control-juveniles exhibited up-regulation of genes involved in positive regulation of reproductive process and oocyte differentiation such aszar1andzpcx. Moreover, EM-females showed higher enrichment than control females in genes involved in VEGF signaling pathway, glycosaminoglycan degradation, hedgehog signaling pathway, GnRH signaling pathway and steroid hormone biosynthesis.ConclusionsOur study shows anti-masculinization in EM-treated adult females but not in EM-treated juveniles. This may be responsible for the lower sex plasticity in adults than juveniles.
Intraoperative changes in whole-blood viscosity in patients undergoing robot-assisted laparoscopic prostatectomy in the steep Trendelenburg position with pneumoperitoneum: a prospective nonrandomized observational cohort study
Authors: Shim Jung-Woo , Moon Hyun Kyung , Park Yong Hyun , Park Misun , Park Jaesik , Lee Hyung Mook , Kim Yong-Suk , Moon Young Eun , Hong Sang Hyun , Chae Min Suk 
Published: January 2020

Abstract
Background
The aim of this study was to investigate the effect of the steep Trendelenburg position (STP) with pneumoperitoneum on whole-blood viscosity (WBV) in patients undergoing robot-assisted laparoscopic prostatectomy (RALP). The study also analyzed the associations of clinical patient-specific and time-dependent variables with WBV and recorded postoperative outcomes.

Methods
Fifty-eight adult male patients (ASA physical status of I or II) undergoing elective RALP were prospectively analyzed in this study. WBV was intraoperatively measured three times: at the beginning of surgery in the supine position without pneumoperitoneum; after 30 min in the STP with pneumoperitoneum; and at the end of surgery in the supine position without pneumoperitoneum. The WBV at a high shear rate (300 s− 1) was recorded as systolic blood viscosity (SBV) and that at a low shear rate (5 s− 1) was recorded as diastolic blood viscosity (DBV). Systolic blood hyperviscosity was defined as > 13.0 cP at 300 s− 1 and diastolic blood hyperviscosity was defined as > 4.1 cP at 5 s− 1.

Results
The WBV and incidences of systolic and diastolic blood hyperviscosity significantly increased from the supine position without pneumoperitoneum to the STP with pneumoperitoneum. When RALP was performed in the STP with pneumoperitoneum, 12 patients (27.3%) who had normal SBV at the beginning of surgery and 11 patients (26.8%) who had normal DBV at the beginning of surgery developed new systolic and diastolic blood hyperviscosity, respectively. The degree of increase in WBV after positioning with the STP and pneumoperitoneum was higher in the patients with hyperviscosity than in those without hyperviscosity at the beginning of surgery. Higher preoperative body mass index (BMI) and hematocrit level were associated with the development of both systolic and diastolic blood hyperviscosity in the STP with pneumoperitoneum. All patients were postoperatively discharged without fatal complications.

Conclusions
Changes in surgical position may influence WBV, and higher preoperative BMI and hematocrit level are independent factors associated with the risk of hyperviscosity during RALP in the STP with pneumoperitoneum.

Trial registration
Clinical Research Information Service, Republic of Korea, approval number: KCT0003295 on October 25, 2018.