bluuebunny/crossref_metadata_2025_split huggingface dataset:
Procedural learning and retention of audio‐verbal temporal sequence is altered in children with developmental coordination disorder but cortical thickness matters
Authors: Lê Margaux , Blais Mélody , Jucla Mélanie , Chauveau Nicolas , Maziero Stéphanie , Biotteau Maëlle , Albaret Jean‐Michel , Péran Patrice , Chaix Yves , Tallet Jessica 
Published: June 2020

AbstractRhythmic abilities are impaired in developmental coordination disorder (DCD) but learning deficit of procedural skills implying temporal sequence is still unclear. Current contradictory results suggest that procedural learning deficits in DCD highly depend on learning conditions. The present study proposes to test the role of sensory modality of stimulations (visual or auditory) on synchronization, learning, and retention of temporal verbal sequences in children with and without DCD. We postulated a deficit in learning particularly with auditory stimulations, in association with atypical cortical thickness of three regions of interesting: sensorimotor, frontal and parietal regions. Thirty children with and without DCD (a) performed a synchronization task to a regular temporal sequence and (b) practiced and recalled a novel non‐regular temporal sequences with auditory and visual modalities. They also had a magnetic resonance imaging to measure their cortical thickness. Results suggested that children with DCD presented a general deficit in synchronization of a regular temporal verbal sequence irrespective of the sensory modality, but a specific deficit in learning and retention of auditory non‐regular verbal temporal sequence. Stability of audio‐verbal synchronization during practice correlated with cortical thickness of the sensorimotor cortex. For the first time, our results suggest that synchronization deficits in DCD are not limited to manual tasks. This deficit persists despite repeated exposition and practice of an auditory temporal sequence, which suggests a possible alteration in audio‐verbal coupling in DCD. On the contrary, control of temporal parameters with visual stimuli seems to be less affected, which opens perspectives for clinical practice.
Prevalence of co‐morbidities and their association with mortality in patients with COVID‐19: A systematic review and meta‐analysis
Authors: Singh Awadhesh K. , Gillies Clare L. , Singh Ritu , Singh Akriti , Chudasama Yogini , Coles Briana , Seidu Sam , Zaccardi Francesco , Davies Melanie J. , Khunti Kamlesh 
Published: June 2020

AbstractAimTo estimate the prevalence of both cardiometabolic and other co‐morbidities in patients with COVID‐19, and to estimate the increased risk of severity of disease and mortality in people with co‐morbidities.Materials and MethodsMedline, Scopus and the World Health Organization website were searched for global research on COVID‐19 conducted from January 2019 up to 23 April 2020. Study inclusion was restricted to English language publications, original articles that reported the prevalence of co‐morbidities in individuals with COVID‐19, and case series including more than 10 patients. Eighteen studies were selected for inclusion. Data were analysed using random effects meta‐analysis models.ResultsEighteen studies with a total of 14 558 individuals were identified. The pooled prevalence for co‐morbidities in patients with COVID‐19 disease was 22.9% (95% CI: 15.8 to 29.9) for hypertension, 11.5% (9.7 to 13.4) for diabetes, and 9.7% (6.8 to 12.6) for cardiovascular disease (CVD). For chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD), cerebrovascular disease and cancer, the pooled prevalences were all less than 4%. With the exception of cerebrovascular disease, all the other co‐morbidities presented a significantly increased risk for having severe COVID‐19. In addition, the risk of mortality was significantly increased in individuals with CVD, COPD, CKD, cerebrovascular disease and cancer.ConclusionsIn individuals with COVID‐19, the presence of co‐morbidities (both cardiometabolic and other) is associated with a higher risk of severe COVID‐19 and mortality. These findings have important implications for public health with regard to risk stratification and future planning.
Historical legacies and ecological determinants of grass naturalizations worldwide
Authors: Monnet Anne‐Christine , Vorontsova Maria S. , Govaerts Rafaël H. A. , Svenning Jens‐Christian , Sandel Brody 
Published: June 2020

The global distribution of exotic species is the result of abiotic, biotic and dispersal filtering processes that shape the movement and success of species outside their native range. In this study we aim to understand how these filtering processes drive the fluxes of grass species among regions, the factors that influence which species establish outside of their native range, and where they do so.We used national and subnational checklists of native and introduced grass species to determine the extent to which each region was a source or recipient of exotic grass species. We asked how species traits may distinguish those grass species that have naturalized outside their native range from those that have not, and how environmental conditions are related to the distribution of exotic grass species.We found that exotic grass establishment is shaped by an array of factors including characteristics of regions, traits of species and their interactions. Regions with a longer history of human occupation and larger numbers of native grass species were generally the most important sources of exotic species. Global flows of species were mostly driven by a climate match between the native and exotic ranges, but were also highly asymmetric, with regions with recent human arrival being the major hosts of exotic grass species. Tall, annual and C4 grass species exhibited particularly high probabilities of establishment outside their native range.Despite the idiosyncrasy and stochasticity characteristic of exotic species establishment, this biogeographical analysis revealed important generalities across this large plant group. Our results suggest that grass species that have co‐occurred with humans for a longer time may be better adapted to living in anthropogenic landscapes, explaining the global asymmetry in species introductions.
Information seeking behaviour of dental trauma patients and their parents
Authors: Bamashmous Nada , Cunningham Susan J. , Parekh Susan 
Published: June 2020

AbstractBackground and AimDental trauma is a common public health issue that can be associated with high costs and lifelong treatment. Children and parents should have the correct information regarding its management to reduce the potential long‐term sequelae. Understanding their information seeking behaviour is therefore important to ensure that they are able to access, understand and retain the relevant information. The aim of this study was to investigate (a) the different ways that patients undertaking treatment for dental trauma, and their parents, look for relevant information, (b) their information needs, and (c) their preferred format of information.Material and MethodsThis was a two‐phase study: Phase I involved in‐depth interviews with 10 patients who were currently undergoing treatment for dental trauma, and 11 parents. In phase II, the themes and sub‐themes identified from the interviews were used to develop patient and parent questionnaires, which were distributed to all trauma patients and parents who fulfilled the inclusion criteria and who were attending the dental clinics from March to May 2014.ResultsPatients and parents had different concerns immediately following the trauma, during treatment and in the long term, and they wanted different forms of information to answer their concerns. Reliability was the main issue about trusting the information available in the Internet, social media and other online sources. Therefore, patients preferred to obtain information verbally from their dentist, while parents preferred written information.ConclusionPatients and parents have different information needs, and these also vary at different stages of treatment. It is therefore important to customize the way information is provided for each group accordingly.
Youth Experience Tracker Instrument: A self‐report measure of developmental antecedents to severe mental illness
Authors: Patterson Victoria C. , Pencer Alissa , Pavlova Barbara , Awadia Alim , MacKenzie Lynn E. , Zwicker Alyson , Drobinin Vladislav , Howes Vallis Emily , Uher Rudolf 
Published: June 2020

AbstractAimWe sought to examine the structure, internal consistency, convergent and criterion validity of the Youth Experience Tracker Instrument (YETI), a new brief self‐report measure designed to facilitate early identification of risk for severe forms of mental illness, including major depressive disorder, bipolar disorder, and schizophrenia.MethodsWe collected 716 YETIs from 315 individuals aged 8 to 27 with and without familial risk of severe mental illness. The YETI measures six developmental antecedents that precede and predict serious forms of mental illness: affective lability, anxiety, basic symptoms, depressive symptoms, psychotic‐like experiences, and sleep. A battery of concurrent questionnaires and interviews measured the same constructs.ResultsThe best‐fitting bifactor model supported the validity of both total score and antecedent‐specific subscales. Internal consistency was high for the total score (ω = 0.94) and subscales (ω = 0.80‐0.92; ρ = 0.72). The total score captured the majority of information from the 26 YETI items (hierarchical omega ωh = 0.74). Correlations of YETI subscales with established measures of the same constructs (r = 0.45‐0.80) suggested adequate convergent validity. We propose cut‐offs with high negative predictive values to facilitate efficient risk screening.ConclusionThe YETI, a brief self‐report measure of antecedents, provides an alternative to using multiple longer instruments. Future research may examine the predictive validity of the YETI for the onset of major mood and psychotic disorders.
Associations between schizotypal personality features, mentalizing difficulties and thought problems in a sample of community adolescents
Authors: Salaminios George , Morosan Larisa , Toffel Elodie , Tanzer Michal , Eliez Stephan , Badoud Deborah , Armando Marco , Debbané Martin 
Published: June 2020

AbstractAimSchizotypal trait expression and mentalizing impairments represent key factors associated with increased vulnerability for schizophrenia. In the current study, we analysed the nature of associations linking specific schizotypal personality features to mentalizing difficulties during adolescence. Furthermore, we examined the extent to which mentalizing difficulties mediate the relationship between schizotypal trait features and self‐reported thought problems.MethodsOne hundred and five community adolescents (Mage = 15.72; SD = 1.91) completed a recently developed self‐report measure of mentalizing (Reflective Functioning Questionnaire [RFQ]), evaluating the degree of certainty (RFQc‐scale) and uncertainty (RFQu‐scale) with which individuals utilize mental state information to understand their own and others' behaviour. High scores on the RFQu‐scale reflect poor usage of mental state information, while high scores on the RFQc‐scale capture adaptive levels of certainty about mental states. Self‐report questionnaires were also used to assess schizotypal trait expression, thought problems and symptoms of anxiety/depression.ResultsLinear regression models indicated that schizotypal features of social anxiety and odd speech accounted for increased RFQu scores, while odd speech also accounted for reduced RFQc scores. RFQu partially mediated the effects of social anxiety and odd speech on the level of thought problems in the sample.ConclusionsPresent findings suggest that schizotypal features that impede interpersonal communication during adolescence are linked to difficulties in mental state understanding. Our study also provides original data suggesting that the effects of social anxiety and odd speech on psychosis‐risk may partially depend upon the level of mentalizing uncertainty. Mentalizing difficulties may constitute important clinical assessment and early prevention treatment targets in adolescents who demonstrate schizotypal features.
Intracisternal IGF‐1 gene therapy abrogates kainic acid‐induced excitotoxic damage of the rat spinal cord
Authors: Nishida Fabián , Zanuzzi Carolina N. , Sisti María S. , Falomir Lockhart Eugenia , Camiña Agustina E. , Hereñú Claudia B. , Bellini María J. , Portiansky Enrique L. 
Published: June 2020

AbstractDevelopment of alternative therapies for treating functional deficits after different neurological damages is a challenge in neuroscience. Insulin‐like growth factor‐1 (IGF‐1) is a potent neurotrophic factor exerting neuroprotective actions in brain and spinal cord. It is used to prevent or treat injuries of the central nervous system using different administration routes in different animal models. In this study, we evaluated whether intracisternal (IC) route for IGF‐1 gene therapy may abrogate or at least reduce the structural and behavioral damages induced by the intraparenchymal injection of kainic acid (KA) into the rat spinal cord. Experimental (Rad‐IGF‐1) and control (Rad‐DsRed‐KA) rats were evaluated using a battery of motor and sensory tests before the injection of the recombinant adenovector (day −3), before KA injection (day 0) and at every post‐injection (pi) time point (days 1, 2, 3 and 7 pi). Histopathological changes and neuronal and glial counting were assessed. Pretreatment using IC delivery of RAd‐IGF‐1 improved animal's general condition and motor and sensory functions as compared to Rad‐DsRed‐KA‐injected rats. Besides, IC Rad‐IGF‐1 therapy abrogated later spinal cord damage and reduced the glial response induced by KA as observed in Rad‐DsRed‐KA rats. We conclude that the IC route for delivering RAd‐IGF‐1 prevents KA‐induced excitotoxicity in the spinal cord.
Financial constraints and the growth and survival of innovative start‐ups: An analysis of Italian firms
Authors: Ferrucci Edoardo , Guida Roberto , Meliciani Valentina 
Published: June 2020

AbstractWe study the impact of measures devoted to relieving financial constraints for the growth and survival of Italian innovative start‐ups. Using balance sheet data on innovative start‐ups and information on the use of the Italian Central Guarantee Fund for small and medium‐sized enterprises, we evaluate whether access to the fund, relieving financial constraints, helps innovative start‐ups survive and grow. We find innovative start‐ups benefit significantly more than similar control firms. We shed light on the relevance of policies aimed at reducing financial constraints for the growth and survival of innovative start‐ups, an issue receiving increasing attention at the European level.
Storytelling for the foreign language classroom
Authors: Sauro Shannon , Buendgens‐Kosten Judith , Cornillie Frederik 
Published: June 2020

AbstractAt a time when many language teachers are looking for research‐based teaching materials that can be modified to support their students in online or digital learning, existing teaching and assessment materials developed through European grant‐funded projects can provide valuable and ready‐to‐use resources. This paper reports on the published and forthcoming teaching materials developed by the FanTALES group for teaching multilingual interactive digital storytelling to low‐to‐high intermediate level learners, more specifically, the B1 level according to the Common European Framework of Reference for Languages: Learning, teaching, assessment.
Trends and change points in surface and bottom thermal environments of the US Northeast Continental Shelf Ecosystem
Authors: Friedland Kevin D. , Morse Ryan E. , Manning James P. , Melrose Donald Christopher , Miles Travis , Goode Andrew G. , Brady Damian C. , Kohut Josh T. , Powell Eric N. 
Published: June 2020

AbstractTemperature is an important factor in defining the habitats of marine resource species. While satellite sensors operationally measure ocean surface temperatures, we depend on in situ measurements to characterize benthic habitats. Ship‐based measurements were interpolated to develop a time series of gridded spring and fall, surface and bottom temperature fields for the US Northeast Shelf. Surface and bottom temperatures have increased over the study period (1968–2018) at rates between 0.18–0.31°C per decade and over a shorter time period (2004–2018) at rates between 0.26–1.49°C per decade. A change point analysis suggests that a warming regime began in the surface waters in 2011 centered on Georges Bank and the Nantucket Shoals; in following years, most of the Northeast Shelf had experienced a shift in surface temperature. A similar analysis of bottom temperature suggests a warming regime began in 2008 in the eastern Gulf of Maine; in following years, change points in temperature occurred further to the west in the Gulf of Maine, finally reaching the Middle Atlantic Bight by 2010. The spatial pattern in bottom water warming is consistent with well‐known oceanographic patterns that advect warming North Atlantic waters into the Gulf of Maine. The varying spatial and temporal progression of warming in the two layers suggests they were actuated by different sets of forcing factors. We then compared these trends and change points to responses of lower and higher trophic level organisms and identified a number of coincident shifts in distribution and biomass of key forage and fisheries species.
Fracture incidence of WaveOne Gold files: a prospective clinical study
Authors: Bueno C. S. P. , Oliveira D. P. , Pelegrine R. A. , Fontana C. E. , Rocha D. G. P. , Gutmann J. L. , Bueno C. E. S. 
Published: June 2020

AbstractAimThis prospective clinical study evaluated the incidence of instrument fracture observed after single‐file root canal treatment of molars using WaveOne Gold instruments.MethodologyThree standardized, experienced and calibrated specialists treated 750 maxillary and mandibular molars with curvatures less than 45° (2691 root canals) over a 12‐month period. All the treatments were performed in a single session. A total of 1104 WaveOne Gold instruments were used, including 38 small, 750 primary, 228 medium and 88 large instruments. Intracanal procedures were performed according to the manufacturer's recommendations, and each instrument was used in a single clinical case. The instruments were examined after their removal from the canal, under an operating microscope at 8× magnification.ResultsNo fractures were observed in any of the 1104 instruments used.ConclusionsNo fractures of WaveOne Gold reciprocating instruments occurred during root canal preparations performed in maxillary and mandibular molars with curvatures less than 45° when used strictly according to the manufacturer's recommendations and applied in a single clinical case.
The effects of preparation and cooking processes on vitamins and antioxidant capacity of sour and spicy potato silk
Authors: Ren Xue , Tang Tiantian , Xie Xinfang , Wang Wenjun , Tang Xuanming , Brennan Charles S. , Zhang Jie , Wang Zhidong 
Published: June 2020

SummaryThe effect of a traditional dish sour and spicy potato silk preparation and cooking process on B vitamins, phenolic profiles and antioxidant activities was investigated. Results showed that cutting of potato caused an increase in VB1, VB2, nicotinic acid, nicotinamide, VB7 and VB9. Soaking decreased the content of B vitamins and vitamin C. Blanching and rinsing caused the contents of B vitamins and vitamin C decrease compared to the control. The content of VB1, VB5 and VB6 after rinsing increased compared to soaking and blanching processes. However, VB1, nicotinamide, VB5, VB6 and VC decreased sharply after the stir‐frying process. The content of VB1, nicotinic acid, nicotinamide, VB7 and VC retained the most after five steps compared to the control. In addition, there was no difference in VB9 contents among different cooking processes compared to the control. Superoxide dismutase (SOD) exhibited a reduction rate of 95.32% and peroxidase (POD) 97.13% after the stir‐frying process.
Optimal channel strategies in a supply chain under green manufacturer financial distress with advance payment discount
Authors: Zhang Chong , Wang Yaxian , Ma Peng 
Published: June 2020

AbstractGreen manufacturers are always faced with capital constraints in reality, while the previous literature has shown that internal financing is more effective than external financing. Given manufacturers' financial constraints, this paper studies and compares the optimal green decisions and profits under single‐channel or dual‐channel strategies with and without green investment. Therefore, the main contribution of the paper is determining the optimal channel strategy of supply chains under advance payment financing. The results indicate that the retailer's optimal channel strategy is to provide advance payment financing to the manufacturer who introduces online channel and produces green products, which are beneficial to the economic and environmental performance. Besides, green investment can facilitate a win‐win scenario if the price elasticity of the demand for the retail channel is smaller than a threshold. Furthermore, green investment increases the retailer's acceptance of online channel. The results of our research can provide decision support for decision makers under the advance payment financing.
Limb salvage procedure in immunocompromised patients with therapy‐resistant leg ulcers—The value of ultra‐radical debridement and instillation negative‐pressure wound therapy
Authors: Geierlehner Alexander , Horch Raymund E. , Müller‐Seubert Wibke , Arkudas Andreas , Ludolph Ingo 
Published: June 2020

AbstractThe purpose of this study was to analyse the outcome of our established triple treatment strategy in therapy‐resistant deep‐thickness chronic lower leg ulcers. This limb salvage approach consists of ultra‐radical surgical debridement, negative‐pressure wound therapy (NPWT) with or without instillation, and split‐thickness skin grafting. Between March 2003 and December 2019, a total of 16 patients and 24 severe cases of lower leg ulcers were eligible for inclusion in this highly selective population. A total of seven patients received immunosuppressive medication. Complete wound closure was achieved in 25% and almost 90% of included lower leg ulcer cases after 3 and 24 months of our triple treatment strategy, respectively. The overall limb salvage rate was 100%. Bacterial colonisation of these wounds was significantly reduced after multiple surgical debridements and NPWT. Fasciotomy and radical removal of devitalised tissue such as deep fascia, tendons, and muscles combined with NPWT showed promising results in terms of the overall graft take rate. This treatment strategy was considered as last resort for limb salvage in such a critically ill and immunocompromised patient population. Surgeons should be aware of its efficacy and consider the triple treatment strategy especially if no other limb salvage option remains.