bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of Galactic free–free emission to the foreground for EoR signal in SKA experiments
Authors: Lian Xiaoli , Xu Haiguang , Zhu Zhenghao , Hu Dan 
Published: April 2020

ABSTRACT
The overwhelming foreground contamination hinders the accurate detection of the 21-cm signal of neutral hydrogen during the Epoch of Reionization (EoR). Among various foreground components, the Galactic free–free emission is less studied, so that its impact on the EoR observations remains unclear. In this work, we employ the observed H α intensity map with the correction of dust absorption and scattering, the simfast21 software, and the latest SKA1-Low layout configuration to simulate the SKA ‘observed’ images of Galactic free–free emission and the EoR signal. By calculating the 1D power spectra from the simulated image cubes, we find that the Galactic free–free emission is about 103.5–102.0, 103.0–101.3, and 102.5–101.0 times more luminous than the EoR signal on scales of 0.1 Mpc−1 &lt; k &lt; 2 Mpc−1 in the 116–124, 146–154, and 186–194 MHz frequency bands. We further analyse the 2D power spectra inside the properly defined EoR window and find that the leaked Galactic free–free emission can still cause non-negligible contamination, as the ratios of its power (amplitude squared) to the EoR signal power can reach about 200, 60, and 15 per cent on scales of k ∼ 1.2 Mpc−1 in three frequency bands, respectively. Therefore, we conclude that the Galactic free–free emission, as a severe contaminating foreground component, needs to be carefully treated in the forthcoming deep EoR observations.
Modelling the spinning dust emission from LDN 1780
Authors: Vidal Matias , Dickinson Clive , Harper S E , Casassus Simon , Witt A N 
Published: April 2020

ABSTRACT
We study the anomalous microwave emission (AME) in the Lynds Dark Nebula (LDN) 1780 on two angular scales. With publicly available data at an angular resolution of 1°, we studied the spectral energy distribution of the cloud in the 0.408–2997 GHz frequency range. The cloud presents a significant (&gt;20σ) amount of AME, making it one of the clearest examples of AME on 1 ° scales, and its spectrum can be well fitted with a spinning dust (SD) model. We also find at these angular scales that the location of the peak of the emission at lower frequencies (23–70 GHz) differs from the location at the higher frequencies (90–3000 GHz) maps. In addition to the analysis on 1° angular scales, we present data from the Combined Array for Research in Millimeter-wave Astronomy (CARMA) at 31 GHz with an angular resolution of 2 arcmin, in order to study the origin of the AME in LDN 1780. We studied morphological correlations between the CARMA map and different infrared tracers of dust emission. We found that the best correlation is with the 70- μm template, which traces warm dust (T ∼ 50 K). Finally, we study the difference in radio emissivity between two locations within the cloud. We measured a factor of ≈6 difference in 31-GHz emissivity. We show that this variation can be explained, using the SD model, by a variation on the dust grain size distribution across the cloud, particularly changing the fraction of polycyclic aromatic hydrocarbon for a fixed total amount of carbon.
Jet-shaped geometrically modified light curves of core-collapse supernovae
Authors: Kaplan Noa , Soker Noam 
Published: April 2020

ABSTRACT
We build three simple bipolar ejecta models for core-collapse supernovae (CCSNe), as expected when the explosion is driven by strong jets, and show that for an observer located in the equatorial plane of the ejecta, the light curve has a rapid luminosity decline, and even an abrupt drop. In calculating the geometrically modified photosphere we assume that the ejecta has an axisymmetrical structure composed of an equatorial ejecta and faster polar ejecta, and has a uniform effective temperature. At early times the photosphere in the polar ejecta grows faster than the equatorial one, leading to higher luminosity relative to a spherical explosion. The origin of the extra radiated energy is the jets. At later times the optical depth decreases faster in the polar ejecta, and the polar photosphere becomes hidden behind the equatorial ejecta for an observer in the equatorial plane, leading to a rapid luminosity decline. For a model where the jets inflate two low-density polar bubbles, the luminosity decline might be abrupt. This model enables us to fit the abrupt decline in the light curve of SN 2018don.
Human Prehistoric Demography Revealed by the Polymorphic Pattern of CpG Transitions
Authors: Liu Xiaoming 
Published: April 2020

Abstract
The prehistoric demography of human populations is an essential piece of information for illustrating our evolution. Despite its importance and the advancement of ancient DNA studies, our knowledge of human evolution is still limited, which is also the case for relatively recent population dynamics during and around the Holocene. Here, we inferred detailed demographic histories from 1 to 40 ka for 24 population samples using an improved model-flexible method with 36 million genome-wide noncoding CpG sites. Our results showed many population growth events that were likely due to the Neolithic Revolution (i.e., the shift from hunting and gathering to agriculture and settlement). Our results help to provide a clearer picture of human prehistoric demography, confirming the significant impact of agriculture on population expansion, and provide new hypotheses and directions for future research.
Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA
Authors: Pan Hai , Jin Miao , Ghadiyaram Ashwin , Kaur Parminder , Miller Henry E , Ta Hai Minh , Liu Ming , Fan Yanlin , Mahn Chelsea , Gorthi Aparna , You Changjiang , Piehler Jacob , Riehn Robert , Bishop Alexander J R , Tao Yizhi Jane , Wang Hong 
Published: April 2020

Abstract
Cohesin SA1 (STAG1) and SA2 (STAG2) are key components of the cohesin complex. Previous studies have highlighted the unique contributions by SA1 and SA2 to 3D chromatin organization, DNA replication fork progression, and DNA double-strand break (DSB) repair. Recently, we discovered that cohesin SA1 and SA2 are DNA binding proteins. Given the recently discovered link between SA2 and RNA-mediated biological pathways, we investigated whether or not SA1 and SA2 directly bind to RNA using a combination of bulk biochemical assays and single-molecule techniques, including atomic force microscopy (AFM) and the DNA tightrope assay. We discovered that both SA1 and SA2 bind to various RNA containing substrates, including ssRNA, dsRNA, RNA:DNA hybrids, and R-loops. Importantly, both SA1 and SA2 localize to regions on dsDNA that contain RNA. We directly compared the SA1/SA2 binding and R-loops sites extracted from Chromatin Immunoprecipitation sequencing (ChIP-seq) and DNA-RNA Immunoprecipitation sequencing (DRIP-Seq) data sets, respectively. This analysis revealed that SA1 and SA2 binding sites overlap significantly with R-loops. The majority of R-loop-localized SA1 and SA2 are also sites where other subunits of the cohesin complex bind. These results provide a new direction for future investigation of the diverse biological functions of SA1 and SA2.
ARIAweb: a server for automated NMR structure calculation
Authors: Allain Fabrice , Mareuil Fabien , Ménager Hervé , Nilges Michael , Bardiaux Benjamin 
Published: April 2020

Abstract
Nuclear magnetic resonance (NMR) spectroscopy is a method of choice to study the dynamics and determine the atomic structure of macromolecules in solution. The standalone program ARIA (Ambiguous Restraints for Iterative Assignment) for automated assignment of nuclear Overhauser enhancement (NOE) data and structure calculation is well established in the NMR community. To ultimately provide a perfectly transparent and easy to use service, we designed an online user interface to ARIA with additional functionalities. Data conversion, structure calculation setup and execution, followed by interactive visualization of the generated 3D structures are all integrated in ARIAweb and freely accessible at https://ariaweb.pasteur.fr.
Extended search for sub-eV axion-like resonances via four-wave mixing with a quasi-parallel laser collider in a high-quality vacuum system
Authors: Nobuhiro Akihide , Hirahara Yusuke , Homma Kensuke , Kirita Yuri , Ozaki Takaya , Nakamiya Yoshihide , Hashida Masaki , Inoue Shunsuke , Sakabe Shuji 
Published: April 2020

Abstract
Resonance states of axion-like particles were searched for via four-wave mixing by focusing two-color pulsed lasers into a quasi-vacuum. A quasi-parallel collision system that allows probing of the sub-eV mass range was realized by focusing the combined laser fields with an off-axis parabolic mirror. A 0.10 mJ/34 fs Ti:sapphire laser pulse and a 0.14 mJ/9 ns Nd:YAG laser pulse were spatiotemporally synchronized by sharing a common optical axis and focused into the vacuum system. No significant four-wave mixing signal was observed at the vacuum pressure of $3.7 \times 10^{-5}$ Pa, thereby providing upper bounds on the coupling-mass relation by assuming exchanges of scalar and pseudoscalar fields at a 95% confidence level in the mass range below 0.21 eV. For this search, the experimental setup was substantially upgraded so that the optical components were compatible with the requirements of the high-quality vacuum system, hence enabling the pulse power to be increased. With the increased pulse power, a new kind of pressure-dependent background photon emerged in addition to the known atomic four-wave mixing process. This paper shows the pressure dependence of these background photons and how to handle them in the search.
The Effect of Pelvic Floor Muscle Interventions on Pelvic Floor Dysfunction After Gynecological Cancer Treatment: A Systematic Review
Authors: Brennen Robyn , Lin Kuan-Yin , Denehy Linda , Frawley Helena C 
Published: April 2020

Abstract

Objective
The aim of this systematic review was to identify, evaluate, and synthesize the evidence from studies that have investigated the effect of nonsurgical, nonpharmacological, pelvic floor muscle interventions on any type of pelvic floor dysfunction or health-related quality of life in patients after any type of treatment for gynecological cancer.

Methods
Six electronic databases (Cochrane Library 2018, CINAHL 1982–2018, MEDLINE 1950–2018, EMBASE 1980–2018, PsycINFO 1806–2018, and EMCARE 1995–2018) were systematically searched in June 2018. Reference lists of identified articles were hand searched. Randomized controlled trials (RCTs), cohort studies, and case series were included if they investigated the effects of conservative treatments, including pelvic floor muscle training or dilator training, on bladder, bowel, or sexual function in patients who had received treatment for gynecological cancer. Risk of bias was assessed using the Physiotherapy Evidence Database scale for RCTs and the Newcastle-Ottawa scale for cohort studies.

Results
Five RCTs and 2 retrospective cohort studies were included (n = 886). The results provided moderate-level evidence that pelvic floor muscle training with counseling and yoga or core exercises were beneficial for sexual function (standardized mean difference = −0.96, 95% CI = −1.22 to −0.70, I2 = 0%) and health-related quality of life (standardized mean difference = 0.63, 95% CI = 0.38 to 0.88, I2 = 0%) in survivors of cervical cancer and very low-level evidence that dilator therapy reduced vaginal complications in survivors of cervical and uterine cancer (odds ratio = 0.37, 95% CI = 0.17 to 0.80, I2 = 54%). There were insufficient data for meta-analysis of bladder or bowel function.

Conclusion
Conservative pelvic floor muscle interventions may be beneficial for improving sexual function and health-related quality of life in survivors of gynecological cancer. Given the levels of evidence reported in this review, further high-quality studies are needed, especially to investigate effects on bladder and bowel function.

Impact
This review provides moderate-level evidence for the role of pelvic floor rehabilitation to improve health outcomes in the gynecological cancer survivorship journey. Clinicians and health service providers should consider how to provide cancer survivors the opportunity to participate in supervised pelvic floor rehabilitation programs.
Indirect Decompression Effect to Central Canal and Ligamentum Flavum After Extreme Lateral Lumbar Interbody Fusion and Oblique Lumbar Interbody Fusion
Authors: Limthongkul Worawat , Tanasansomboon Teerachat , Yingsakmongkol Wicharn , Tanaviriyachai Terdpong , Radcliff Kris , Singhatanadgige Weerasak 
Published: April 2020

Study Design.
A retrospective study (level of evidence: level 4).

Objective.
To evaluate the radiographic outcomes after extreme lateral lumbar interbody fusion (XLIF) and oblique lateral lumbar interbody fusion (OLIF) procedures especially the effect of indirect decompression to the ligamentum flavum and to evaluate the effect of facet degeneration to the radiographic outcomes of these procedures.

Summary of Background Data.
Indirect decompression via lateral lumbar interbody fusion provides spinal canal area expansion. However, the effect to the ligamentum flavum area and thickness at the operated spinal level is unclear.

Methods.
Thirty-five patients (57 lumbar levels) underwent XLIF or OLIF with percutaneous pedicle screw fixation (PPS) without direct posterior decompression were retrospectively studied. Radiographic parameters including ligamentum flavum area (LFA), ligamentum flavum thickness (LFT), cross-sectional area (CSA) of thecal sac, posterior disc height, foraminal height, cage alignment, and facet degeneration were measured on magnetic resonance image (MRI). Cage position was assessed with plain radiography.

Results.
All of the radiographic parameters were significantly improved. Comparing pre- and postoperative value, mean LFA decreased from 78.9 ± 24.9 mm2 to 66.9 ± 26.8 mm2 (–14.2%; P-value < 0.00625). Mean right LFT decreased from 2.9 ± 0.9 mm to 2.3 ± 0.7 (–17.0%; P-value < 0.00625). Mean left LFT decreased from 3.3 ± 1.6 mm to 2.6 ± 0.9 mm (–17.6%; P-value < 0.00625). Mean CSA of thecal sac increased from 93.1 ± 43.0 mm2 to 127.3 ± 52.5 mm2 (50.8%; P-value < 0.00625). All radiographic outcomes were not significant difference between lumbar levels that have grade 0–1 and grade 2–3 or between grade 2 and grade 3 facet degeneration.

Conclusion.
Ligamentum flavum area and thickness were significantly reduced after lateral lumbar interbody fusion through both XLIF and OLIF. Unbuckling of the ligamentum flavum played an important role for improvement of spinal canal area after the indirect decompression.

Level of Evidence: 4
Association Between Modic Changes and Low Back Pain in Middle Age
Authors: Saukkonen Jesperi , Määttä Juhani , Oura Petteri , Kyllönen Eero , Tervonen Osmo , Niinimäki Jaakko , Auvinen Juha , Karppinen Jaro 
Published: April 2020

Study Design.
A cross-sectional study of the Northern Finland Birth Cohort 1966 (NFBC1966).

Objective.
The aim of this study was to evaluate the association between the type, size, and location of lumbar Modic changes (MC), and prolonged disabling low back pain (LBP).

Summary of Background Data.
LBP is the leading cause of disability worldwide and it affects all age- and socioeconomical groups. Only a small proportion of LBP patients are diagnosed with a specific cause: In most cases no single nociceptive cause for the pain can be identified. MC are visualized in magnetic resonance imaging (MRI) as a signal intensity change in vertebral bone marrow and have been proposed to represent a specific degenerative imaging phenotype associated with LBP. MC can be classified into several subtypes, of which inflammatory Type 1 (MC1) is suggested as being more likely to be associated with LBP.

Methods.
We assessed lumbar MRI (n = 1512) for the presence, type, and size of MC. The associations of MC characteristics with prolonged (≥30 days during the past year) and disabling (bothersomeness of LBP at least 6 on a 0–10 Numeric Rating Scale) LBP, evaluated at the time of imaging at 47 years, were analyzed using binary logistic regression, adjusted for sex, BMI, smoking, educational status, lumbar disc degeneration, and disc herniations.

Results.
Any MC and MC1 were associated with prolonged disabling LBP (odds ratio [OR] after full adjustments 1.50 [95% confidence interval, CI 1.05–2.15] and 1.50 [95% CI 1.10–2.05], respectively). Furthermore, MC covering the whole anterior-posterior direction or the whole endplate, as well as the height of MC, were significantly associated with prolonged disabling LBP (OR after full adjustments 1.59 [95% CI 1.14–2.20], 1.67 [95% CI 1.13–2.46] and 1.26 [95% CI 1.13–1.42], respectively).

Conclusion.
Our study showed a significant and independent association between MC and clinically relevant LBP.

Level of Evidence: 3
Whole Spine CT Scan for the Detection of Acute Spinal Fractures in Diffuse Idiopathic Skeletal Hyperostosis Patients Who Sustained Low-energy Trauma
Authors: Dan Lantsman Christine , Barkay Gal , Friedlander Alon , Barbi Merav , Stern Myriam , Eshed Iris 
Published: April 2020

Study Design.
Retrospective cohort study.

Objective.
The aim of this study was to evaluate the role and value of whole-spine computerized tomography (WSCT) versus radiographs and targeted CT to tender spinal regions in patients with diffuse idiopathic skeletal hyperostosis (DISH) after low-energy trauma.

Summary of Background Data.
Subjects with DISH are prone to spinal fractures even after low-impact trauma due to a rigid spinal structure.

Methods.
One-hundred forty-seven subjects (average age: 83 years, M:F 64/83) with verified DISH (Resnick and Niwayama radiographic criteria) on WSCT who were admitted to the emergency room (ER) after low-energy trauma and for whom there were radiographs of at least the thoracic and lumbar spine were evaluated for the presence of acute spinal fractures on both radiographs and WSCT. Agreement between fracture location and spinal tenderness location (cervical, thoracic, or lumbar) as reported in the medical record was evaluated.

Results.
Significantly more acute fractures were detected on WSCT compared to radiographs (55 and 32, P < 0.00001, respectively). The site of tenderness was not indicative of the fractured spinal segment in 57% of all acute fractures (seven cervical, 15 thoracic, and 16 lumbar). No fracture was detected on WSCT in 10 subjects with an unspecified pain location. Multilevel distant fractures were detected in two patients with a specified pain location to only one of the fractures.

Conclusion.
WSCT in DISH subjects after low-impact trauma is mandatory due to the high prevalence of acute fractures and the low specificity for fracture detection on radiographs. A targeted CT approach to the tender spinal segment proved to be inadequate and would have missed 57% of the acute single fractures with incompatible spinal tenderness location. These results support the significant role of WSCT in the ER setting for detecting and pinpointing the spinal fracture site of DISH subjects who present with low-impact trauma.

Level of Evidence: 3
Treatment in Disproportionately Minority Hospitals Is Associated With Increased Risk of Mortality in Sepsis: A National Analysis*
Authors: Rush Barret , Danziger John , Walley Keith R. , Kumar Anand , Celi Leo Anthony 
Published: April 2020

Objectives:
Treatment in a disproportionately minority-serving hospital has been associated with worse outcomes in a variety of illnesses. We examined the association of treatment in disproportionately minority hospitals on outcomes in patients with sepsis across the United States.

Design:
Retrospective cohort analysis. Disproportionately minority hospitals were defined as hospitals having twice the relative minority patient population than the surrounding geographical mean. Minority hospitals for Black and Hispanic patient populations were identified based on U.S. Census demographic information. A multivariate model employing a validated algorithm for mortality in sepsis using administrative data was used.

Setting:
The National Inpatient Sample from 2008 to 2014.

Patients:
Patients over 18 years of age with sepsis.

Interventions:
None.

Measurements and Main Results:
A total of 4,221,221 patients with sepsis were identified. Of these, 612,217 patients (14.5%) were treated at hospitals disproportionately serving the black community (Black hospitals), whereas 181,141 (4.3%) were treated at hospitals disproportionately serving the Hispanic community (Hispanic hospitals). After multivariate analysis, treatment in a Black hospital was associated with a 4% higher risk of mortality compared to treatment in a nonminority hospital (odds ratio, 1.04; 95% CI, 1.03–1.05; p < 0.01). Treatment in a Hispanic hospital was associated with a 9% higher risk of mortality (odds ratio, 1.09; 95% CI, 1.07–1.11; p < 0.01). Median hospital length of stay was almost 1 day longer at each of the disproportionately minority hospitals (nonminority hospitals: 5.9 d; interquartile range, 3.1–11.0 d vs Hispanic: 6.9 d; interquartile range, 3.6–12.9 d and Black: 6.7 d, interquartile range, 3.4–13.2 d; both p < 0.01).

Conclusions:
Patients with sepsis regardless of race who were treated in disproportionately high minority hospitals suffered significantly higher rates of in-hospital mortality.
Diagnosis of the accurate genotype of HKαα carriers in patients with thalassemia using multiplex ligation-dependent probe amplification combined with nested polymerase chain reaction
Authors: Chen Dong-Mei , Ma Shi , Tang Xiang-Lan , Yang Ji-Yun , Yang Zheng-Lin 
Published: April 2020

Abstract

Background:
Patients carrying the HongKongαα (HKαα) allele and -α

3.7

/ααα

anti-4.2
could be misdiagnosed as -α
3.7/αα by the current conventional thalassemia detection methods, leading to inaccurate genetic counseling and an incorrect prenatal diagnosis. This study was aimed to accurately analyze the genotypes of HKαα carriers and -α
3.7/ααα
anti-4.2.

Methods:
Samples were collected in our hospital from July 2017 to October 2019. Twenty-four common types of Chinese thalassemia were screened by gap-polymerase chain reaction (Gap-PCR) and reverse dot blot (RDB). Anti-4.2 multiplex-PCR was used to confirm carriers of the ααα
anti-4.2 duplication with -α
3.7 deletion. Two-round nested PCR and multiplex ligation-dependent probe amplification (MLPA) were applied to accurately identify and confirm their genotypes. For data analysis, we used descriptive statistics and Fisher's exact tests.

Results:
Two thousand five hundred and forty-four cases were identified as thalassemia in 5488 peripheral blood samples. The results showed that α, β, and αβ compound thalassemia were identified in 1190 (46.78%), 1286 (50.55%), and 68 (2.67%) cases, respectively. A total of 227 samples from thalassemia patients were identified as -α
3.7/αα by Gap-PCR, and the genotypes of two samples were uncertain. There was a difference between Gap-PCR and combined groups (Gap-PCR combined with nested PCR and MLPA) in detecting HKαα (P < 0.05). Among the 229 patients, 20 patients were identified as HKαα carriers and one was identified as -α
3.7/ααα
anti-4.2 by two-round nested PCR and MLPA, including 15 patients with HKαα/αα, three with HKαα/αα and β-thalassemia coinheritance, one with HKαα/--SEA, one with HKαα/-α4.2 and β-thalassemia coinheritance, and one with -α
3.7/ααα
anti-4.2 and β-thalassemia coinheritance.

Conclusions:

ααα
anti-4.2 and HKαα genotypes of patients carrying -α
3.7 need to be detected to reduce the misdiagnosis rate of patients carrying HKαα and -α3.7/ααα
anti-4.2 alleles. More accurate genetic counseling can be provided in the clinic using nested PCR combined with MLPA.