bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasonic wave propagation characteristics for typical anisotropic failure modes of shale under uniaxial compression and real-time ultrasonic experiments
Authors: Li Yingjie , Wang Bingqian , Song Lihong , Liu Jie , Zuo Jianping , Liu Dejun 
Published: December 2019

AbstractUniaxial loading and real-time ultrasonic experiments on shales were conducted to study the progressive failure of shale and the ultrasonic propagation characteristics during loading. The results show that the variations in P-wave and S-wave velocities with stress correspond to the crack damage process for the typical anisotropic failure of shale, and that the S-wave amplitude is sensitive to the damage that arises in shale during loading. If the bedding participates relatively simply in the failure (0° and 60° inclinations), the spectrum and the main frequency shape are simple and remain basically unchanged during loading. In the cases where the failure mode is complicated by the participation of the bedding and the matrix (30° and 90° inclinations), the spectrum and the main frequency shape are complex and change dynamically with loading. These results indicate that ultrasonic dynamic parameters reflect the differences in the failure of shale.
The partial banana mapping: a robust linear method for impact probability estimation
Authors: Vavilov Dmitrii E 
Published: December 2019

ABSTRACT
This paper presents a robust linear method for impact probability estimation of near-Earth asteroids with the Earth. This method is a significantly modified and improved method, which uses a special curvilinear coordinate system associated with the nominal orbit of an asteroid. One of the coordinates of this system is the mean anomaly in the osculating orbit of an asteroid. A normal distribution of errors of coordinates and velocities of this system is assumed. Because of the usage of the curvilinear coordinate system, the fact that the confidence region is curved and stretched mainly along the nominal asteroid orbit is taken into account. On the main axis of the curvilinear confidence ellipsoid the virtual asteroid, which is the closest to the Earth, is found. The part of the curvilinear confidence ellipsoid, around the found virtual asteroid, is obtained and mapped on to its target plane. The impact probability is calculated as the probability of the asteroid being in the region of the found virtual asteroid multiplied by the probability of a collision of the found virtual asteroid with the Earth. This approach is shown to give more accurate and trustworthy results than the target plane method.
Probabilities of Unranked and Ranked Anomaly Zones under Birth–Death Models
Authors: Kim Anastasiia , Rosenberg Noah A , Degnan James H 
Published: December 2019

AbstractA labeled gene tree topology that is more probable than the labeled gene tree topology matching a species tree is called “anomalous.” Species trees that can generate such anomalous gene trees are said to be in the “anomaly zone.” Here, probabilities of “unranked” and “ranked” gene tree topologies under the multispecies coalescent are considered. A ranked tree depicts not only the topological relationship among gene lineages, as an unranked tree does, but also the sequence in which the lineages coalesce. In this article, we study how the parameters of a species tree simulated under a constant-rate birth–death process can affect the probability that the species tree lies in the anomaly zone. We find that with more than five taxa, it is possible for species trees to have both anomalous unranked and ranked gene trees. The probability of being in either type of anomaly zone increases with more taxa. The probability of anomalous gene trees also increases with higher speciation rates. We observe that the probabilities of unranked anomaly zones are higher and grow much faster than those of ranked anomaly zones as the speciation rate increases. Our simulation shows that the most probable ranked gene tree is likely to have the same unranked topology as the species tree. We design the software PRANC, which computes probabilities of ranked gene tree topologies given a species tree under the coalescent model.
Evolution and distribution of medullary bone: evidence from a new Early Cretaceous enantiornithine bird
Authors: Wang Min , O’Connor Jingmai K , Bailleul Alida M , Li Zhiheng 
Published: December 2019

AbstractLiving birds are unique among vertebrates in the formation of a female-specific bone tissue called medullary bone (MB) that is strictly associated with reproductive activity. MB is a rapidly mobilized source of calcium and phosphorus for the production of eggshell. Among living taxa, its skeletal distribution can be highly extensive such that it even exists in the ribs of some species. Due to its ephemeral nature, MB is rarely fossilized and so little is understood with regard to the origin of MB and its skeletal distribution in early taxa. Here we describe a new Early Cretaceous enantiornithine bird, Mirusavis parvus, gen. et. sp. nov., indicating that skeleton-wide distribution of MB appeared early in avian evolution. We suggest that this represents the plesiomorphic condition for the Aves and that the distribution of MB observed among extant neornithines is a product of increased pneumatization in this lineage and natural selection for more efficient distribution of MB.
The Biological Impact of Menthol on Tobacco Dependence
Authors: Wickham Robert J 
Published: December 2019

AbstractIn the 1920s, tobacco companies created a marketing campaign for what would one day be their most profitable series of products: mentholated tobacco cigarettes. Menthol provides the smoker with a pleasant mint flavor in addition to a cooling sensation of the mouth, throat, and lungs, giving relief from the painful irritation caused by tobacco smoke. Promising a healthier cigarette using pictures of doctors in white coats and even cartoon penguins, tobacco companies promoted these cigarettes to young, beginner smokers and those with respiratory health concerns. Today, smoking tobacco cigarettes causes one in five US Americans to die prematurely, crowning it as the leading cause of preventable death. In contrast to the dubious health claims by tobacco companies, mentholated cigarettes are in fact more addictive. Smokers of mentholated cigarettes have lower successful quit rates and in some cases are resistant to both behavioral and pharmacological treatment strategies. There is now considerable evidence, especially in the last 5 years, that suggest menthol might influence the addictive potential of nicotine-containing tobacco products via biological mechanisms. First, menthol alters the expression, stoichiometry, and function of nicotinic receptors. Second, menthol’s chemosensory properties operate to mask aversive properties of using tobacco products. Third, menthol’s chemosensory properties aid in serving as a conditioned cue that can both enhance nicotine intake and drive relapse. Fourth, menthol alters nicotine metabolism, increasing its bioavailability. This review discusses emerging evidence for these mechanisms, with an emphasis on preclinical findings that may shed light on why menthol smokers exhibit greater dependence.ImplicationsMentholated cigarettes have been shown to have greater addictive potential than their nonmentholated counterparts. Evidence is pointing toward multiple mechanisms of action by which menthol may alter tobacco dependence. Understanding menthol’s biological functions as it pertains to nicotine dependence will be helpful in crafting novel pharmacotherapies that might better serve menthol smokers. In addition, a better understanding of menthol’s pharmacology as it relates to tobacco dependence will be valuable for informing policy decisions on the regulation of mentholated cigarettes.
Clinical Implications of the CMV-Specific T-Cell Response and Local or Systemic CMV Viral Replication in Patients With Moderate to Severe Ulcerative Colitis
Authors: Jung Kyung Hwa , Kim Jihun , Lee Ho-Su , Choi Jene , Jang Se Jin , Jung Jiwon , Kim Min Jae , Chong Yong Pil , Lee Sang-Oh , Choi Sang-Ho , Kim Yang Soo , Woo Jun Hee , Park Sang Hyoung , Yang Dong-Hoon , Ye Byong Duk , Yang Suk-Kyun , Kim Sung-Han 
Published: December 2019

Abstract

Background
The precise role of cytomegalovirus (CMV) in ulcerative colitis (UC) remains disputed. We evaluated the association of CMV-specific host immune responses and systemic or local viral replication with responses to systemic steroids in patients with moderate to severe UC.

Methods
Patients who were hospitalized for moderate to severe UC between April 2015 and June 2016 were enrolled. At baseline, all enrolled patients underwent CMV-specific enzyme-linked immunospot assays, quantitative polymerase chain reaction (qPCR) analysis of blood and colonic tissue for CMV viral load, histopathological testing for CMV in colonic tissue by hematoxylin and eosin staining, and immunohistochemical (IHC) analysis. Clinical responses to steroid therapy based on the Oxford index were assessed on day 3.

Results
Of the 80 patients evaluated, 28 (35.0%) had poor responses to steroid therapy on day 3 of intensive treatment. The presence of inclusion bodies (32.1%) and high-grade (≥3) positivity on IHC (50.0%), as well as colonic (mean 1440.4 copies/mg) and blood (mean, 3692.6 copies/mL) CMV viral load, were higher in steroid-refractory UC patients than the control group (13.5%, 1.9%, mean 429.2 copies/mg, and mean 231.2 copies/mL, respectively; P = .046, .009, .017, and .002, respectively). However, CMV-specific T-cell responses were not associated with steroid-refractory UC. Multivariate analysis revealed that a higher Mayo score (odds ratio [OR], 2.00; P = .002) and higher blood CMV viral load via qPCR analysis (OR, 3.58; P = .044) were independent risk factors for steroid-refractory UC.

Conclusions
In patients with moderate to severe UC, higher Mayo score and blood CMV expression determined by qPCR are independently associated with steroid refractoriness.

ClinicalTrials.gov registration number
NCT 02439372.
Computed Tomography Guidance for Percutaneous Glycerol Rhizotomy for Trigeminal Neuralgia
Authors: Schmidt Bradley T , Pun Conrad D , Lake Wendell B , Resnick Daniel K 
Published: December 2019

Abstract

Background
Percutaneous glycerol rhizotomy (PGR) is a well-described treatment for trigeminal neuralgia; however, the technique in using surface landmarks and fluoroscopy has not drastically changed since being first introduced. In this paper, we describe a protocol for PGR using computed tomography (CT) guidance based on an experience of over 7 yr and 200 patients.

Objective
To introduce an approach for PGR using CT guidance and, in doing so, demonstrate possible benefits over the traditional fluoroscopic technique.

Methods
Using a standard CT scanner, patients are placed supine with head in extension. Barium paste and a CT scout image are used to identify and plan a trajectory to the foramen ovale. A laser localization system built into the CT scanner helps to guide placement of the spinal needle into the foramen ovale. The needle position in the foramen is confirmed with a short-sequence CT scan.

Results
CT-guided PGR provides multiple benefits over standard fluoroscopy, including improved visualization of the skull base and significant reduction in radiation exposure to the surgeon and staff. Side benefits include improved procedure efficiency, definitive imaging evidence of correct needle placement, and potentially increased patient safety. We have had no significant complications in over 200 patients.

CONCLUSION
CT-guided PGR is a useful technique for treating trigeminal neuralgia based on better imaging of the skull base, better efficiency of the procedure, and elimination of radiation exposure for the surgeon and staff compared to traditional fluoroscopic based techniques.
Randomized Controlled Trial Comparing Landmark and Ultrasound-Guided Glossopharyngeal Nerve in Eagle Syndrome
Authors: Sundaram Shanmuga , Punj Jyotsna 
Published: December 2019

Abstract

Introduction
The glossopharyngeal nerve lies posterior to the internal carotid artery at the submandibular region. The primary objective of this study was to compare ultrasound-guided glossopharyngeal nerve block (UGPNB) and landmark glossopharyngeal nerve block (GPNB).

Materials & Methods
Inclusion criteria were patients with unilateral Eagle syndrome and ear pain. Group UGPNB (N = 25) received three UGPNBs at weekly intervals with 1.5 mL of 0.5% ropivacaine and 20 mg of methylprednisolone. Group GPNB (N = 26) received landmark GPNB. Pain intensity was evaluated with the numerical rating scale (NRS) before every block, 30 minutes after every block, and at one, three, and five weeks after the third block. Quality of life, assessed using the Brief Pain Inventory (BPI), and satisfaction scores were noted.

Results
NRS scores before the second and third blocks and a week after were significantly lower in group UGPNB and comparable at weeks 3 and 5. NRS scores 30 minutes after every block were significantly decreased from the preblock values but were comparable between groups. In 68% of patients, a curvilinear probe delineated the internal carotid artery (ICA). Out-of-plane needle trajectory was required in 64% of patients. BPI and satisfaction scores were significantly better in the UGPNB group in the “block” weeks.

Conclusions
UGPNB with 1.5 mL of 0.5% ropivacaine and 20 mg of methylprednisolone injected posterior to the ICA in the submandibular region provides better pain relief for at least a week compared with an extraoral landmark technique when three weekly consecutive blocks are given. In most patients, a curvilinear probe and out-of-plane needle trajectory are most suitable for ultrasound block.
Shared unfolding pathways of unrelated immunoglobulin-like β-sandwich proteins
Authors: Toofanny Rudesh D , Calhoun Sara , Jonsson Amanda L , Daggett Valerie 
Published: December 2019

Abstract
The Dynameomics project contains native state and unfolding simulations of 807 protein domains, where each domain is representative of a different metafold; these metafolds encompass ~97% of protein fold space. There is a long-standing question in structural biology as to whether proteins in the same fold family share the same folding/unfolding characteristics. Using molecular dynamics simulations from the Dynameomics project, we conducted a detailed study of protein unfolding/folding pathways for 5 protein domains from the immunoglobulin (Ig)-like β-sandwich metafold (the highest ranked metafold in our database). The domains have sequence similarities ranging from 4 to 15% and are all from different SCOP superfamilies, yet they share the same overall Ig-like topology. Despite having very different amino acid sequences, the dominant unfolding pathway is very similar for the 5 proteins, and the secondary structures that are peripheral to the aligned, shared core domain add variability to the unfolding pathway. Aligned residues in the core domain display consensus structure in the transition state primarily through conservation of hydrophobic positions. Commonalities in the obligate folding nucleus indicate that insights into the major events in the folding/unfolding of other domains from this metafold may be obtainable from unfolding simulations of a few representative proteins.
Intensity of spinal inflammation is associated with radiological structural damage in patients with active axial spondyloarthritis
Authors: Huang Jin Xian , Chung Ho Yin , Chui Eva Tze Fung , Lee Kam Ho , Chan Shirley Chiu Wai , Tsang Helen Hoi Lun , Ng Alexandra Hoi Yan 
Published: December 2019

Abstract

Objective
The aim was to investigate the relationship between the intensity of spinal inflammation using the apparent diffusion coefficient (ADC) and radiographic progression in axial SpA.

Methods
This is a cross-sectional study of participants with axial SpA and back pain. Clinical, biochemical and radiological parameters were collected. The ankylosing spondylitis disease activity score (ASDAS)-CRP was determined. Radiographic progression was represented by the modified Stoke ankylosing spondylitis spine score (mSASSS). MRI with short tau inversion recovery (STIR) and diffusion-weighted imaging sequences were performed simultaneously. Inflammatory lesions on STIR were used for the Spondyloarthritis Research Consortium of Canada (SPARCC) MRI indexes and as references in outlining regions of interest in ADC maps to produce mean (ADCmean) and maximal (ADCmax) ADC values. Univariate and multivariate linear regression analyses were used to determine independent associations between ADC and radiographic progression.

Results
The 84 participants with identifiable lesions on spinal ADC maps recruited were characterized by a mean (s.d.) age of 45.01 (13.68) years, long disease duration [13.40 (11.01) years] and moderate clinical disease activity [ASDAS-CRP 2.07 (0.83)]. Multivariate regression analysis using ADCmean as the independent variable showed that age (regression coefficient [B] = 0.34; P = 0.01), male sex (B = 0.25; P = 0.04) and ADCmean (B = 0.30; P = 0.01) were positively associated with mSASSS. Multivariate regression analysis using ADCmax as the independent variable showed a tendency for ADCmax to be associated with mSASSS (B = 0.21; P = 0.07).

Conclusion
The intensity of spinal inflammation as determined by ADC is associated with radiographic progression in participants with active axial SpA.
NATIONAL OBSERVATORY OF ELECTROMAGNETIC FIELDS: NATIONAL TELEMETRIC NETWORK FOR THE MEASUREMENT OF HIGH-FREQUENCY ELECTROMAGNETIC FIELDS IN GREECE
Authors: Karastergios I , Gialofas A , Karabetsos E 
Published: December 2019

Abstract
At the end of 2015, the operation of the National Observatory of Electromagnetic Fields (established in 2012) has started. The National Observatory of Electromagnetic Fields is a network of 500 fixed (480 broadband and 20 frequency selective) and 13 mobile (vehicle mounted frequency selective) measurement stations throughout Greece that continuously monitor the electromagnetic field levels from all kinds of antenna stations in the frequency range 100kHz–7GHz. The results of this national monitoring network, which is operated and controlled by the Greek Atomic Energy Commission (EEAE), are presented through an interactive web portal (https://paratiritirioemf.eeae.gr), in which data are constantly updated with the latest station measurements. This paper presents the operational aspects and the measurement results of the first 3 years of operation (2016–2018). The measurement results revealed that all values were well below the reference levels for general public exposure, as defined by the Greek legislation.
Sensorimotor Induction of Auditory Misattribution in Early Psychosis
Authors: Salomon Roy , Progin Pierre , Griffa Alessandra , Rognini Giulio , Do Kim Q , Conus Philippe , Marchesotti Silvia , Bernasconi Fosco , Hagmann Patric , Serino Andrea , Blanke Olaf 
Published: December 2019

Abstract
Dysfunction of sensorimotor predictive processing is thought to underlie abnormalities in self-monitoring producing passivity symptoms in psychosis. Experimentally induced sensorimotor conflict can produce a failure in bodily self-monitoring (presence hallucination [PH]), yet it is unclear how this is related to auditory self-monitoring and psychosis symptoms. Here we show that the induction of sensorimotor conflict in early psychosis patients induces PH and impacts auditory-verbal self-monitoring. Participants manipulated a haptic robotic system inducing a bodily sensorimotor conflict. In experiment 1, the PH was measured. In experiment 2, an auditory-verbal self-monitoring task was performed during the conflict. Fifty-one participants (31 early psychosis patients, 20 matched controls) participated in the experiments. The PH was present in all participants. Psychosis patients with passivity experiences (PE+) had reduced accuracy in auditory-verbal self-other discrimination during sensorimotor stimulation, but only when sensorimotor stimulation involved a spatiotemporal conflict (F(2, 44) = 6.68, P = .002). These results show a strong link between robotically controlled alterations in sensorimotor processing and auditory misattribution in psychosis and provide evidence for the role of sensorimotor processes in altered self-monitoring in psychosis.
Connectomic Underpinnings of Working Memory Deficits in Schizophrenia: Evidence From a replication fMRI study
Authors: Yang Jie , Pu Weidan , Wu Guowei , Chen Eric , Lee Edwin , Liu Zhening , Palaniyappan Lena 
Published: December 2019

AbstractBackgroundWorking memory (WM) deficit is a key feature of schizophrenia that relates to a generalized neural inefficiency of extensive brain areas. To date, it remains unknown how these distributed regions are systemically organized at the connectome level and how the disruption of such organization brings about the WM impairment seen in schizophrenia.MethodsWe used graph theory to examine the neural efficiency of the functional connectome in different granularity in 155 patients with schizophrenia and 96 healthy controls during a WM task. These analyses were repeated in another independent dataset (81 patients and 54 controls). Linear regression analysis was used to test associations of altered graph properties, clinical symptoms, and WM accuracy in patients. A machine-learning approach was adopted to study the ability of multivariate connectome features from one dataset to discriminate patients from controls in the second dataset.ResultsSmall-worldness of the whole-brain connectome was significantly increased in schizophrenia during the WM task; this increase is related to better (though subpar) WM accuracy in patients with more severe negative symptom burden. There was a shift in the degree distribution to a more homogeneous form in patients. The machine-learning approach classified a new set of patients from controls with 84.3% true-positivity rate for schizophrenia and 71.6% overall accuracy.ConclusionsWe demonstrate a putative mechanistic link between connectome topology, hub redistribution, and impaired n-back performance in schizophrenia. The task-dependent modulation of the connectome relates to, but remains inefficient in, improving the performance above par in the presence of severe negative symptoms.
Banking crises and the modern tax state
Authors: Limberg Julian 
Published: December 2019

AbstractHave banking crises boosted path-breaking fiscal innovations? Drawing on the literature that deals with the impact of warfare on fiscal capacity, I argue that banking crises have facilitated the rise of progressive tax instruments by causing revenue needs and demands for fiscal fairness. I test this argument by means of event history analyses and new worldwide data on the introduction of the two main pillars of the modern tax state: the personal income tax (PIT) and the general sales tax (GST). Furthermore, I examine the adoption of PIT in the USA and Argentina. The findings stress the importance of financial and economic crises for fiscal institutions and call for a closer investigation of how non-bellicist shocks have shaped the modern state.
State Abortion Restrictions and the New Supreme Court: Women's Access to Reproductive Health Services
Authors: Reingold Rebecca B. , Gostin Lawrence O. 
Published: December 2019

(Abstracted from JAMA 2019;322(1):21–22)
The US Supreme Court's landmark 1973 ruling in Roe v Wade established a privacy right to choose abortion. However, in more recent years, many judicial cases have emerged as blatant challenges to this ruling.