bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare Case of Bilateral Malignant Brenner Tumors of the Ovaries Associated with Peritoneal Effusion
Authors: Tong Jianing , Niu Jianmin , Li Qiaoyun , Hu Li , Zhang Hui 
Published: October 2020

Abstract
Background: Malignant ovarian Brenner tumors are extremely rare worldwide, accounting for only 1% of malignant ovarian tumors. Their clinical symptoms and pathology are complex and erratic, and the images are mostly non-specific. This poses difficulties in preoperative diagnosis and distinguishing them from other cystic solid ovarian tumors. Here this study has reported on a case of bilateral malignant ovarian Brenner tumor with peritoneal effusion. Case presentation: A 54-year-old woman presented with intermittent vaginal bleeding for more than two months and abdominal pain for one month. Two hard mass of five centimeters with poor movement could be touched at each side of the ovarian areas. The CT findings indicated the presence of two large cystic and solid masses in both adnexal regions. The operation had watched the size of the masses in the bilateral ovarian was both 6cmx6cmx5cm and their surface ulceration showed rotten fleshy tissue. After the operation, combined with morphological and immunohistochemical features, the ovarian specimens were consistent with bilateral ovarian malignant Brenner tumors.Conclusions: Although the incidence of bilateral malignant OBT is extremely low and this disease is extremely rare clinically, the gynecologists should be more informed of its diagnosis and treatment.
Chondromyxoid Fibroma-Like Osteosarcoma in Thoracic Spine with Azygos Tumor Thrombosis, A Case Report
Authors: Du Chuanchao , Liu Shanshan , Liu Yu , Liu Xiaoguang , Wei Feng 
Published: October 2020

Abstract
Background: Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is extremely rare subtype of osteosarcoma, its clinical data is scarce, understanding of it is far from enough. Besides, it is short of typical imaging manifestations, it is not uncommon to be misdiagnosed clinically. Meantime azygos vein thrombosis is also a rare entity, and there is a big controversy over treatments for it.Case presentation: Herein, we report a case of CMF-OS that occurred in spine, coincidently, azygos vein thrombosis was found. A young male patient came to our clinic because of continuous back pain, then neoplastic lesion was suspected in thoracolumbar vertebrae. The pathological results of the biopsy showed low grad of osteosarcoma, and chondromyxoid fibroma-like osteosarcoma was the primary diagnosis. Since the tumor cannot be en-bloc resected, he received palliative decompression surgery, followed by radio and chemotherapy. Azygos vein tumor thrombosis was not intervened, unfortunately, he died of heart failure caused by the thrombus migrated from azygos vein to right atrium. Before the palliative decompression surgery, both the patient and the clinical team were trapped in the dilemma of how big surgery should be done to maximize the benefits of this patient. Conclusions: CMF-OS is indeed more aggressive than its pathological sections look like. Guidelines for osteosarcoma should be followed. Besides, it is important to recognize the danger of tumor thrombosis in azygos vein. Preventive measures have to be done timely to avoid catastrophic results.
Non-Small Cell Lung Cancer Causing Atraumatic Splenic Rupture Without Splenic Metastasis: A Case Report
Authors: Pepe Russel J. , Parekh Akshat , Butts Christopher , Ehsani-Nia Hamid , Amro Chris 
Published: October 2020

Abstract
BackgroundWhile atraumatic splenic rupture is rare phenomenon, its potential lethality emphasizes its clinical importance. Disseminated neoplastic disease is a known mechanism of atraumatic splenic rupture. Case PresentationThis case report discusses a patient presenting with tension hydrothorax and atraumatic splenic rupture in the setting of non-small cell lung carcinoma requiring emergent chest tube insertion and splenectomy. This patient’s presentation represents only the second documented case of atraumatic splenic rupture secondary to metastatic lung carcinoma without pathological evidence of splenic metastasis. ConclusionsThis unique case emphasizes the importance of assessing structural integrity of the spleen in patients with metastatic non-small cell lung carcinoma, as neoplastic atraumatic splenic rupture conveys a significant mortality risk.
Effect of Ulceration on the Therapeutic Benefit of Surgery in Patients with Stage IV Melanoma: A Surveillance, Epidemiology, and End Results Analysis from 2004–2015
Authors: Zhao Qiqi , Gao Zeyun , Xu Xuezhu 
Published: October 2020

Abstract
Background: The effects of various surgical options and ulcerations on the survival of patients with stage IV skin malignant melanoma are unknown. Therefore, we evaluated the potential of these factors as prognostic markers in patients with stage IV malignant melanoma. Methods: We included 5760 patients from 2004–2015 who are screened from the SEER datasets in the study. The patients were divided into four groups: the R 0 group, the primary tumor resection group, the metastasectomy group, and the no-resection group. The median follow-up survival time and overall survival were compared between the four groups as primary outcomes. Result: The R0 , primary tumor resection, metastasectomy, and no-resection groups had median survival times of 11, 13, 20, and 4 months, respectively ( p <0.001). Cox (proportional hazards) regression models estimated that patients in the R 0 , primary tumor resection, and metastasectomy groups had longer survival benefits, with hazard ratios of 0.396 (95% confidence interval [CI], 0.347–0.453), 0.509 (95% CI, 0.465–0.556), and 0.481 (95% CI, 0.447–0.519), respectively. Conclusion: We highlight the importance of surgery in metastatic melanoma; each surgical group in this study is independently correlated with increased survival. In addition, the patient’s ulceration status is able to predict surgical treatment; however, in the ulcerated melanoma cases, caution should be exercised when considering a metastasectomy.
One Case Report of Desmoplastic Small Round Cell Tumor of Pleura
Authors: Zhang Xiao-bo , Li Sheng-lin , Su Xin , Zhang Rui-hao , Hu Yi-cun , Wang Ke-Ping , Zhou Hai-yu 
Published: October 2020

Abstract
BACGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive malignancy tumor that often affects the abdomen, especially in males. Extra-abdominal DSRCT is extremely rare. CASE REPORT: Here we report a 33-year-old man diagnosed with DSRCT from pleura without any clinical symptoms. Routine blood examination was normal, and an X-ray examination revealed a chest mass during the routine physical examination. The patient was diagnosed by immunohistochemistry combined with clinical features and imaging examination and finally confirmed by pathology. After the diagnosis, we immediately underwent surgery and postoperative radiotherapy. In the latest follow-up, there was no sign of recurrence. CONCLUSION: Because the disease is asymptomatic at the beginning, it is easy to deteriorate, and there is no specific targeted treatment. Therefore, early diagnosis and treatment are particularly important.
Ruscogenin Alleviates Intestinal Bleeding and Blood Flow Induced by Dasatinib&nbsp;through ROCK/MLC Pathway
Authors: Liu Yuankai , Dai Yujie , Xu Han , Zhou Qianliu , Li Fang , Yu Boyang , Zhang Yuanyuan , Kou Junping 
Published: October 2020

Abstract
BackgroundAs a second-generation broad-spectrum tyrosine kinase inhibitor, Dasatinib has the antitumor effect of inhibiting tyrosine kinases such as BCR-ABL and SRC. It is mainly used to treat chronic and acute patients with chronic myelogenous leukemia. However, Dasatinib has many side effects, including gastrointestinal bleeding, respiratory infections, and renal failure, and effective means to improve the side effects of drugs are lacking.MethodsC57BL/6 mice and HUVECs were used to evaluate the side effects caused by dasatinib, RUS was administered in advance to prevent, protein expression and phosphorylation were measured by western blot, and monitored the intestinal bleeding with Laser Doppler Blood Flow Monitor. ResultsWe found that Ruscogenin (RUS) can improve Side effects caused by Dasatinib. Through the Laser Doppler Blood Flow Monitor, it was found that after Dasatinib was administered, blood flow in mice are decreased, and intestinal Evans blue leakage increased. Western blot results showed that connexin (ZO-1, VE-cadherin, Occludin) is destroyed, the activation of ROCK increases, and the phosphorylation of MLC increases. Ruscogenin can reverse the above phenomenon and improve the side effects of gastrointestinal bleeding caused by Dasatinib. In vitro, giving Ruscogenin in advance can protect the endothelial barrier damage caused by Dasatinib, reduce the remodeling of F-actin, and restore the expression of connexin (ZO-1, VE-cadherin), inhibit the activation of ROCK, and reduce Phosphorylation of MLC. ConclusionsThis study provides a new direction for improving the side effects caused by clinical drugs and confirm that Ruscogenin could improve the side effect from Dasatinib by ROCK/MLC pathway.
Progression of Severity in Coronavirus Disease 2019 Patients Before Treatment and a Self-Assessment Scale to Predict Disease Severity
Authors: Yao Ye , Tian Jie , Meng Xia , Kan Haidong , Zhou Lian , Wang Weibing 
Published: October 2020

Abstract
Background: With the pandemic of Coronavirus Disease 2019, differing case-fatality rates and limited resources have led to adoption of separate management strategies for severe and nonsevere disease. For patients in quarantine in the community, self-assessment of COVID-19 severity risk can guide appropriate medical consultation. Methods: Data from 45,450 patients infected with COVID-19 from January 1 to February 27, 2020 were extracted from the municipal Notifiable Disease Report System in Wuhan, China. T-test and chi-square test were used to investigate the associations of various patient characteristics with disease severity, and multivariable logistic regression models identified strongly correlated variables for inclusion in the scale. Scale accuracy was assessed using receiver operating characteristic analysis. A least absolute shrinkage and selection operator regression cross-validated prediction accuracy.Results: Twelve scale items - age, gender, illness duration, dyspnea, shortness of breath (clinical evidence of altered breathing), hypertension, pulmonary disease, diabetes, cardio/cerebrovascular disease, number of comorbidities, neutrophil percentage, and lymphocyte percentage - were identified and showed good predictive ability (area under the curve =0·72). After excluding the community healthcare laboratory parameters, the remaining model (the final self-assessment scale) showed similar area under the curve (=0·71).Conclusions: Our COVID-19 severity self-assessment scale can be used by patients in the community to predict their risk of developing severe illness and the need for further medical assistance. The tool is also practical for use in preliminary screening in community healthcare settings.
Development and Validation of a Novel Predictive Nomogram for Disease Progression of COVID-19: A Multicenter Retrospective Cohort Study of 4,086 Cases in China
Authors: Li Li , Li Shen , Zhang Xiaohua , Cheng Lixia , Mao Qing , Li Qi , Fang Xiaoyu , Li Zhujun , Wang Bin , Zhao Songtao , Zhou Yi , Liu Kaijun , Li Chuanwei , Hou Chao , Sun Fenfen , Sun Qidi , Li Mengxia , Wang Fusheng , Zhang Sibing , Xu Dixiong , Ma Xiangyu , Cao Guoqiang 
Published: October 2020

Abstract
Aim: Coronavirus disease 2019 (COVID-19) has caused an unprecedented healthcare crisis. We aim to develop and validate a nomogram for predicting disease progression based on a large cohort of hospitalized COVID-19 patients. Methods: This is a multicenter retrospective cohort study, with a total of 4,086 hospitalized COVID-19 patients enrolled from two hospitals in Wuhan, China between February 3rd and Apr 10th. Nomogram was developed based on a cohort of 3, 022 patients from one hospital, and externally validated in another cohort of 1,064 patients from the other hospital. The calibration was assessed by a calibration plot and the HL test to evaluate the goodness of fit, and the Area under the ROC Curve (AUROC) as a measure of discriminative ability.Results: Six independent predictors, including age, dyspnea, platelet count, lactate dehydrogenase, D-dimer and cardiovascular disease, were finally identified for construction of the nomogram for predicting disease progression of COVID-19 patients during hospitalization. The AUROC was 0.877 and 0.817 for development cohort and validation cohort, respectively. The calibration plots AND Hosmer-Lemeshow test showed optimal agreement between nomogram prediction and actual observation. The decision curve analysis showed the performance of the nomograms were better than all univariable models, and had greater net benefit. Next, a predictive nomogram for disease severity on admission was formulated and the six independent factors used were similar to that of the nomogram for disease progression, which indicates that those factors play important roles in determining disease severity and the risk of disease progression. Conclusion: In the current study, a nomogram was developed based on generally readily available variables at hospital admission to help predict disease progression of COVID-19.
Controlling Nutritional Status (CONUT) Score is a Prognostic Marker in III-IV NSCLC&nbsp;Patients Receiving First-line Chemotherapy
Authors: Zhang Yi , Kong Fei-Fei , Zhu Zheng Qiu 
Published: October 2020

Abstract
Background: To investigate the prognostic impact of the controlling nutritional status (CONUT) score in non-small-cell lung cancer (NSCLC) patients receiving first-line chemotherapy.Methods: We retrospectively reviewed 278 consecutive patients undergoing chemotherapy for stage III-IV NSCLC between May 2012 and July 2020. CONUT score was calculated by incorporating serum albumin, total cholesterol, and total lymphocyte count. The clinicopathological features and follow-up data were evaluated to compare the CONUT score with other prognostic indices, such as the systemic immune-inflammation index (SII) and prognostic nutritional index (PNI), in patients with NSCLC. Results: Applying cut-offs of ≥3 (CONUT), ≥443.607 (SII), and ≥49.05 (PNI). The high CONUT group had a significantly shorter progression-free survival and overall survival than the low CONUT group. A high CONUT score was significantly associated with older age, worse ECOG PS, advanced clinical stage, and lower PNI (all P < 0.05). In the univariate analysis, higher SII, higher CONUT, advanced clinical stage and lower PNI were associated with worse PFS (P<0.05). Worse ECOG PS, higher SII, higher CONUT, advanced clinical stage and lower PNI were associated with worse OS (P<0.05). In multivariate analysis, SII and CONUT score were independently correlated with PFS (P<0.05), while PNI and CONUT score were independently correlated with OS (P<0.05).Conclusion: CONUT score is an independent prognostic indicator of poor outcomes for patients with stage III-IV NSCLC and is superior to the SII and PNI in terms of prognostic ability.Trial registration: retrospectively registered.
Frequency and diagnostic reliability of laboratory variables in cows with traumatic reticuloperitonitis and type 1, 2, 3, 4 and 5 abomasal ulcer
Authors: Braun Ueli , Nuss Karl , Warislohner Sonja , Reif Christina , Oschlies Carina , Gerspach Christian 
Published: October 2020

Abstract
Background: A number of laboratory abnormalities occur in cows with traumatic reticuloperitonitis (TRP) as well as in those with abomasal ulcers (AU). This prompted us to compare the frequencies of laboratory abnormalities of healthy cows and cows with TRP and cows with abomasal ulcers and to calculate diagnostic sensitivities and specificities, predictive values and positive likelihood ratios for laboratory findings. The study included 182 healthy control cows, 503 cows with TRP, 94 cows with U1, 145 cows with U2, 60 cows with U3, 87 cows with U4 and 14 cows with U5. Haematocrit, total leukocyte count, concentrations of total protein, fibrinogen, urea, potassium and chloride, base excess and rumen chloride concentration were analysed.Results: Values outside the reference interval occurred in 2 to 24% of control cows (rumen chloride 2%, urea 6%, serum chloride 11%, haematocrit 13%, base excess 18%, fibrinogen 20%, total protein 21%, total leukocyte count 22% and potassium 24%), which made differentiation of healthy and ill cows difficult. Therefore, the variables best suited for distinguishing healthy and ill cows were rumen chloride and blood urea concentration. This was also supported by an LR+ of 14 to 27 for rumen chloride >30 mmol/l and 6 to 15 for blood urea >6.5 mmol/l in cows with ulcers. Urea also had a high diagnostic specificity and like rumen chloride was suited for differentiation of healthy and diseased cows. The urea concentration was >8.5 mmol/l in only 0.5% of controls, and the LR+ for a urea concentration >8.5 mmol/l ranged from 11 in cows with TRP to 128 in cows with U2. Except for cows with TRP, azotaemia was significantly more frequent in ill cows than in controls. Cows with U2 (70%) had urea concentrations >8.5 significantly more often than cows of the other groups, which may have been prerenal azotaemia attributable to hypovolaemia. Even though the groups of ill cows differed significantly with respect to several variables, no variables were identified to reliably differentiate the various groups.Conclusions: Isolated results are not suitable to distinguish among groups of ill cows and instead the history, the clinical findings and results of additional diagnostic techniques such as ultrasonography are required.
Changes of microbiota and metabolome of the equine hindgut during oligofructose-induced laminitis
Authors: Maimaiti Tuniyazi. , He Junying , Guo Jian , Li Shuang , Zhang Naisheng , Hu Hu , Fu Yunhe 
Published: October 2020

Abstract
Background: Laminitis is a common but serve conditions caused by inflammatory and pathologic changes of the laminar junction. However, the pathologic mechanism remains unclear. In this study we aimed to investigate changes of the gut microbiota and metabolomics in oligofructose-induced laminitis of horses. Results: Treatment with oligofructose had lower fecal pH but higher lactic acid, histamine, and Lipopolysaccharide (LPS) in serum. Meanwhile, oligofructose altered composition of the hindgut bacterial community, demonstrated by increasing relative abundance of Lactobacollus and Megasphaere. In addition, the metabolome analysis revealed that treatment of oligofructose decreased 84 metabolites while 53 metabolites increased, such as dihydrothymine, N3,N4-Dimethyl-L-arginine, 10E,12Z-Octadecadienoic acid, and asparagine. Pathway analysis revealed that aldosterone synthesis and secretion, regulation of lipolysis in adipocytes, steroid hormone biosynthesis, pyrimidine metabolism, biosynthesis of unsaturated fatty acids, and galactose metabolism were significantly different between healthy and laminitis horses. Furthermore, correlation analysis between gut microbiota and metabolites indicated that Lactobacillus and/or Megasphaera were positively associated with the dihydrothymine, N3,N4-Dimethyl-L-arginine, 10E,12Z-Octadecadienoic acid, and asparagine. Conclusions: These results revealed that disturbance of gut microbiota and changes of metabolites were occurred during the development of equine laminitis, and these results may provide novel insights to detect biomarkers for a better understanding of the potential mechanism and prevention strategies for laminitis in horses.
Evaluation of the consumption and contamination level of Vegetables and Fruits in Ethiopia
Authors: Derra Firehiwot Abera , Bedada Tesfaye , Edichio Redwan , Gabre Samson , Gobena Waktola , Fekade Rahel , Yohannes Tigist , Sebsibe Kaleab , Kassim Tatek , Pal Mahindra 
Published: October 2020

Abstract
Background; Vegetables and Fruits have got major acceptance in the modern scientific world nowadays and advisable to use more per daily food consumption. Although these food products have got more acceptances, their preparation and sanitation before consumption at the household level have to get proper attention. Objective: The objective was to assess the microbial load of vegetables and fruits which had been submitted at the Public health microbiology laboratory of Ethiopian Public Health Institute, from the year 2008- 2017, ( 10 years Retrospective data).Methods: Samples were tested for the presence of Mold, Yeast, Mesophilic aerobic bacteria, Total coliform, Thermo-tolerant coliform and the Indicator E.coli, to determine the contamination level based on the NMKL protocol. For viable bacteria count, APHA protocol was applied. Result: One hundred ninety-five 5.9% (195/ 3279) raw and processed products had been received per ten years. Of these, 15% (29/195) of the samples revealed an intolerable microbial quality of the mesophilic aerobic plate count, followed by total coliforms 7.7% (15/195), thermo-tolerant coliforms 10.8 % (21/ 195), E.coli 3 % (6/ 195), mold count 1.5% (3/195) and yeast count 1.5% (3/195) (ICMSF protocol). Discussion and Conclusion: Although vegetables and fruits are currently proved to be the best healthy foods worldwide and are available with the low cost relatively, in the developing countries like Ethiopia, their consumption rate is overwhelmed by cereals and animal products based on the live status of the community. Therefore, joint efforts have to be exerted by different branches of MOH for encouraging the community to use vegetables and fruits as its main food source for better health and to reduce nasty illnesses like diabetes, obesity, heart diseases and so on. However, while doing so, series health education has to be provided on sanitation procedures like immediate cooking or disinfection before consumption to prevent the community from environmental risks.