bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the clinical outcomes and cement distribution patterns after percutaneous vertebroplasty in the treatment of thoracolumbar Kümmell’s disease and OVCFs
Authors: Wang Cheng-Liang , Chen Ji-Bin , Li Te 
Published: March 2020

Abstract
Background The purpose of this study is to investigate and compare the therapeutic effect and distribution characteristics of bone cement in the PVP treatment for thoracolumbar Kümmell's diseases and OVCFs. Methods A prospective analysis of 35 patients with Kümmell ’s disease (K group) and 35 patients with OVCFs (O group) who underwent PVP treatment from February 2016 to February 2018 was conducted. The vertebral compression rate and degree of osteoporosis were more serious in the K group than in the O group ( P <0.05, respectively). Distribution pattern, volume and leakage rate of bone cement, operation time, VAS score, ODI, correction rates of vertebral compression and kyphosis, re-fracture rate of adjacent vertebrae in 2 years between the two groups were compared to assess clinical effect. Results The follow-up time of the two groups was 24-48 months. The amount of intraoperative bone cement injection was significantly higher in the K group than in the O group ( P =0.025). The cement distribution pattern of local solid lump was dominant in the K group (65.71%), while intercalation with trabeculae was dominant in the O group (74.29%) ( P <0.001). VAS score and ODI were significantly lower both in the two groups at 1 day, 1 year and 2 years after surgery than before surgery (all P <0.05), but significantly lower in the K group than in the O group at each time point after surgery (all P <0.05). The correction rates of kyphosis and vertebral compression in both groups was significantly corrected ( P <0.05, respectively) and gradually lost with time ( P <0.05, respectively). The correction rates of kyphosis and vertebral compression were significantly higher in the K group than in the O group at each time point after surgery (all P <0.05). Conclusions PVP has the advantages of simple operation, short operation time, small trauma and quick recovery in treating both Kümmell's disease and OVCFs. However, PVP can better restore partial vertebral height and correct kyphosis in the treatment of Kümmell's disease, while can better alleviate pain and improve ODI in the treatment of OVCFs.
Effects of β-carotene intake on the risk of fracture: A Bayesian meta-analysis
Authors: Charkos Tesfaye Getachew , Liu Yawen , Oumer Kemal Sherefa , Vuong Ann M , Yang Shuman 
Published: March 2020

Abstract
Introduction The association between β-carotene intake and risk of fracture has been reported inconsistently. We conducted a meta-analysis to investigate the association between β-carotene intake and risk of fracture using a Bayesian approach. Methods We systematically searched PubMed, EMBASE and Cochrane library database for relevant articles until December 2019. We also performed a hand search based on reference lists from published articles. The Bayesian random effect model was used to synthesize data from individual studies. Results Nine studies with a total of 190,545 men and women were included in this meta-analysis. The participants' average age was 59.8 years old. For β-carotene intake, the pooled RR of any fracture was 0.67 (95% Credible Interval (CrI): 0.51-0.82; heterogeneity: P = 0.66, I 2 =0.00%) and 0.63 (95%CrI: 0.44-0. 82) for hip fracture. By study design, the pooled RRs were 0.55 (95% CrI: 0.14-0.96) for case-control studies and 0.82 (95% CrI: 0.58-0.99) for cohort studies. By geographic region, the pooled RRs were 0.58 (95% CrI: 0.28-0.89) for studies conducted in China, 0.86 (95% CrI: 0.35-0.1.37) in America and 0.91(95% CrI: 0.75-1.00) Europe. By gender: the pooled RRs were 0.88 (95% CrI: 0.73-0.99) for males and 0.76 (95% CrI: 0.44-1.07) for females. The probability that β-carotene intakes reduce the risk of any fracture and hip fracture by more than 20% was 95%. Conclusion The present meta-analysis suggests that β-carotene intake was inversely associated with fracture risk, consistently observed for case-control and cohort studies. Further randomized control trial is warranted to confirm this finding.
Barriers to Effective Prescribing in the Elderly: Applying the Theoretical Domains Framework in the Ambulatory Setting
Authors: Lau Sabrina , Lun Penny , Ang Wendy , Tan Keng Teng , Ding Yew Yoong 
Published: March 2020

Abstract
Aims: As the population ages, potentially inappropriate prescribing (PIP) in the elderly may become increasingly prevalent. This undermines patient safety and creates a potential source of major morbidity and mortality. Understanding the factors that influence prescribing behaviour may allow development of interventions to reduce PIP. The aim of this study is to apply the Theoretical Domains Framework (TDF) to explore barriers to effective prescribing in the elderly in the ambulatory setting.Methods: A scoping review was performed based on the five-stage methodological framework developed by Arksey and O’Malley. Our search strategy included PubMed, CINAHL, EMBASE, the Cochrane Database of Systematic Reviews, and Web of Science. We also searched five electronic journals, Google and Google Scholar to identify additional sources and grey literature. Two reviewers applied eligibility criteria to the title and abstract screening, followed by full text screening, before systematically charting the data. Results: 5,731 articles were screened. 29 studies met the selection criteria for qualitative analysis. Using TDF, 14 domains for barriers to effective prescribing were identified. Significant domains include physician-related factors such as “Knowledge”, “Skills”, and “Social/Professional Role and Identity”; issues with “Environmental Context and Resources”; and the impact of “Social Influences” and “Emotion” on prescribing behaviour.Conclusion: The TDF elicited multiple domains which both independently and collectively lead to barriers to effective prescribing in elderly patients in the ambulatory setting. Changing the prescribing climate will thus require interventions targeting multiple stakeholders, including physicians, patients and hospital/clinic systems. Moving forward, we will perform a Delphi study to explore individual domains and ultimately develop a physician-pharmacist collaborative care intervention to guide prescribing for the elderly in the ambulatory setting.
Impact of the duration of preoperative glycemic control on perioperative neutrophil functions in diabetic mice with chronic hyperglycemia: a laboratory research report
Authors: Fujimoto Daichi , Nomura Yuki , Egi Moritoki , Obata Norihiko , Mizobuchi Satoshi 
Published: March 2020

Abstract
BACKGROUND: The risk of surgical site infection has been reported to be higher in patients with poorly controlled diabetes. Since chronic hyperglycemia impairs neutrophil functions, preoperative glycemic control may restore neutrophil function. However, long-term insulin therapy may lead to a delay in surgery, which may be a problem especially in cancer surgery. It is therefore unfortunate that there was no study to investigate the optimal duration of perioperative glycemic control for diabetes with chronic hyperglycemia. Therefore, we investigated the effects of preoperative long-term insulin therapy and short-term insulin therapy on perioperative neutrophil functions in diabetic mice with chronic hyperglycemia. METHODS: Five-week-old mice were administered streptozotocin to induce diabetes. We divided the diabetic mice into three groups: a group of mice with untreated diabetes (untreated group), a group of mice that received insulin therapy for 6 hours before surgery (short-term group) and a group of mice that received insulin therapy for 5 days before surgery (long-term group). A group of non-diabetic mice were used as a control group. At 14 weeks of age, abdominal surgery with intestinal manipulation was performed in all four groups. We carried out a phagocytosis assay by fluorescent microspheres and a reactive oxygen species (ROS) production assay by DCFH-DA (2’,7’-dichlorodihydrofluorescin diacetate) before and after surgery using FACSVerse™ with BD FACSuite™ software. Phagocytosis rate (%) was calculated by dividing the number of phagocytic beads by neutrophil count. Fluorescence from DCF (dichlorofluorescein) in the neutrophils was measured and expressed as mean fluorescence intensity (MFI). RESULTS: Blood glucose was lowered by insulin therapy in the short-term and long-term groups before the operation. Neutrophilic phagocytosis activities before and after the operation were significantly restored in the long-term group compared with those in the untreated group (before: p = 0.0008, after: p = 0.0005). However, they were not significantly restored in the short-term group. Neutrophilic ROS production activities before and after the operation were not restored in either the short-term group or long-term group. CONCLUSIONS: Preoperative and postoperative phagocytosis activities are restored by insulin therapy for 5 days before the operation but not by insulin therapy for 6 hours before the operation.
Mineral compositions and thermobarometry of basalts and boninites recovered during IODP Expedition 352 to the Bonin forearc
Authors: Whattam Scott A. , Shervais John W. , Reagan Mark K. , Coulthard Daniel A. , Pearce Julian A. , Jones Peter , Seo Jieun , Putirka Keith , Chapman Timothy , Heaton Daniel , Li Hongyan , Nelson Wendy R. , Shimizu Kenji , Stern Robert J. 
Published: March 2020

AbstractCentral aims of IODP Expedition 352 were to delineate and characterize the magmatic stratigraphy in the Bonin forearc to define key magmatic processes associated with subduction initiation and their potential links to ophiolites. Expedition 352 penetrated 1.2 km of magmatic basement at four sites and recovered three principal lithologies: tholeiitic forearc basalt (FAB), high-Mg andesite, and boninite, with subordinate andesite. Boninites are subdivided into basaltic, low-Si, and high-Si varieties. The purpose of this study is to determine conditions of crystal growth and differentiation for Expedition 352 lavas and compare and contrast these conditions with those recorded in lavas from mid-ocean ridges, forearcs, and ophiolites. Cr# (cationic Cr/Cr+Al) vs. TiO2 relations in spinel and clinopyroxene demonstrate a trend of source depletion with time for the Expedition 352 forearc basalt to boninite sequence that is similar to sequences in the Oman and other suprasubduction zone ophiolites. Clinopyroxene thermobarometry results indicate that FAB crystallized at temperatures (1142–1190 °C) within the range of MORB (1133–1240 °C). When taking into consideration liquid lines of descent of boninite, orthopyroxene barometry and olivine thermometry of Expedition 352 boninites demonstrate that they crystallized at temperatures marginally lower than those of FAB, between ~1119 and ~1202 °C and at relatively lower pressure (~0.2–0.4 vs. 0.5–4.6 kbar for FAB). Elevated temperatures of boninite orthopyroxene (~1214 °C for low-Si boninite and 1231–1264 °C for high-Si boninite) may suggest latent heat produced by the rapid crystallization of orthopyroxene. The lower pressure of crystallization of the boninite may be explained by their lower density and hence higher ascent rate, and shorter distance of travel from place of magma formation to site of crystallization, which allowed the more buoyant and faster ascending boninites to rise to shallower levels before crystallizing, thus preserving their high temperatures.
Synthesis of New Heteroaryl Substituted Morpholine Tagged Triazines and Evaluation of their Cytotoxic Activity
Authors: Kasturi Sivaprasad , Surarapu Sujatha , Uppalanchi Srinivas , Anantaraju Hasitha Shilpa , Dwivedi Shubham , Yogeeswari Perumal , Ethiraj Krishna S. , Anireddy Jaya Shree 
Published: March 2020

Background:
In the present study, new triazine derivatives 3, 4, 5, 6, 8 and 10 were
synthesized starting from readily available cyanuric chloride 1 via nucleophilic displacement with
morpholine followed by Suzuki or Stille coupling reactions and then the thermal displacement of
chlorine atom with diverse substituted amines.

Methods:
All synthesized compounds were screened for their cytotoxic activity against HT-29,
MDA-MB-231, and HEK293 cell lines.

Results and Conclusion:
Compounds 6a (IC50 (µM): 0.32 for HT-29 and 2.92 for MDA-MB-231)
and 8c (IC50 (µM): 1.40 for HT-29 and 1.60 for MDA-MB-231) have been identified and compared
with Doxorubicin and ZSTK474 as the reference standards.
The Effectiveness of Different Treatment Modalities for the Management of Ocular Injuries Following Sulfur Mustard Exposure
Authors: Panahi Yunes , Naderi Mostafa , Nekoozadeh Shahbaz , Rajaee Seyyed Mahdi , Sahebkar Amirhossein 
Published: March 2020

Background:
Mustard gas or sulfur mustard (dichloro-3-thiapentane-1,5) is a chemical
compound consisting of chlorine and sulfur which was used as a chemical weapon in the First
World War and during the war between Iran and Iraq. Mustard gas is a lipophilic compound that is
highly poisonous and can quickly penetrate into body tissues. Eye is one of the body organs that is
quite vulnerable to this compound. The present study was conducted to review the effectiveness of
various treatments for ocular injuries caused by sulfur mustard.

Methods:
In this review, therapeutic effects of anti-inflammatory drugs such as dexamethasone,
diclofenac, betamethasone and their combination, as well as surgical interventions based on stem
cells and different methods of keratoplasty [e.g. penetrating keratoplasty (PKP), lamellar keratoplasty
(LKP), and deep anterior lamellar keratoplasty (DALK)] were assessed.

Results:
As the results indicated, combinatorial therapeutic approaches are more successful compared
with single therapeutic measures. It has been reported that utilization of anti-inflammatory
drugs such as diclofenac, dexamethasone and betamethasone can control the initial symptoms. In
addition, keratolimbal allograft stem cell transplantation methods along with LKP and PKP keratoplasty
methods can lead to considerable therapeutic success.

Conclusion:
Considering the involvement of multiple abnormalities in the pathogenesis of sulfur
mustard-induced chronic ocular complications, combinatorial therapeutic approaches appear to be
more efficacious.
Perbandingan EQ-5D-5L dan SF-6D Untuk Mengukur Index Utility Kesehatan Pada Populasi Umum di Yogyakarta
Authors: Andayani Tri Murti , Endarti Dwi , Kristina Susi Ari , Rahmawati Anindya 
Published: March 2020

The EuroQuality of life-5 dimension 5 level (EQ-5D-5L) and Short Form-6 Dimension (SF-6D) are the most widely used generic instruments for assessing utility as an outcome parameter in pharmacoeconomic studies. Different instruments cause different utility values and influence the decision making. The purpose of this study was to compare the utility score index measured using EuroQuality of life-5 dimension 5 levels (EQ-5D-5L) and Short Form-6 Dimension (SF-6D) in general population. The study was conducted cross sectional design in general population in the Yogyakarta. EQ-5D-5L and SF-6D questionnaires were given to 470 respondents to measure the utility score index. Differences of utility index scores based on demographic characteristics were analyzed using Mann Whitney and Kruskal Wallis test, while correlations between EQ-5D and SF-6D domains with utility scores were analyzed using Pearson Correlation. Limits of agreement were described by Bland and Altman Plot. The results of the study showed the utility scores measured using EQ-5D-5L, EQ-VAS, and SF-6D were 0.944 (SD = 0.093), 0.829 (SD = 0.089) and 0.915 (SD = 0.081) respectively. EQ-5D-5L and EQ-VAS can distinguish utility values based on age. There is a strong correlation (> 0.700) between the domain of mobility and pain with the EQ-5D-5L utility index, and the domain of physical function and pain with the SF-6D utility index. Ceiling effect of EQ-5D-5L (59%) is greater than SF-6D (22.4%). The Bland and Altman plot shows the difference in utility scores of EQ-5D-5L with SF-6D, SF-6D with EQ-VAS, and EQ-5D-5L with VAS, respectively at the limit of agreement 92.98%, 96 , 38%, and 95.74%. EQ-5D-5L can distinguish utility scores based on age, but showed higher ceiling effect. Both EQ-5D-5L and SF-6D showed a strong correlation between the domain of mobility (physical function) and pain with the utility score.
Pendampingan Soft Skill Pada Siswa-Siswi SMK Muhammadiyah 2 Malang
Authors: Anwar Zainul , 'Azizah Annisa' Taqiyyatul , Fikriyati Alya 
Published: March 2020

Sekolah Menengah Kejuruan (SMK) merupakan pendidikan yang mempersiapkan peserta didik untuk dapat bekerja dalam bidang tertentu dengan keahlian tertentu sesuai dengan kejuruannya. Siswa – siswi SMK memang disiapkan untuk dapat langsung terjun di dunia kerja. Dunia kerja percaya bahwa sumber daya manusia yang unggul adalah mereka yang tidak hanya memiliki kemahiran hard skills saja tetapi juga memiliki soft skills yang baik. Dunia pendidikan pun mengungkapkan bahwa berdasarkan penelitian di Harvard University Amerika Serikat ternyata kesuksesan seseorang tidak ditentukan semata-mata oleh pengetahuan dan kemampuan teknis (hard skills) saja, tetapi lebih oleh kemampuan mengelola diri dan orang lain (soft skills). Penelitian ini mengungkapkan, bahwa kesuksesan hanya ditentukan sekitar 20% oleh hard skills dan sisanya 80% oleh soft skills. Subjek dalam kegiatan ini adalah siswa-siswi SMK Muhammadiyah 2 Tlogomas Malang dengan tujuan untuk mengembangkan soft skill siswa-siswi SMK. Metode yang digunakan berupa pendampingan dengan beberapa kegiatan, yaitu asesmen, pelatihan, dan konseling individual. Hasil dari pengabdian ini menggambarkan bahwa siswa-siswi SMK sangat tertarik dengan adanya pendampingan soft skills dan melalui kegiatan ini siswa – siswi dapat mengetahui potensi (soft skills) yang mereka miliki sehingga membantunya dapat lebih mudah untuk mengoptimalkan soft skills-nya.
Three-dimensional nasal septum and maxillary changes following rapid maxillary expansion in patients with cleft lip and palate:
Authors: Veloso Natália Costa , Mordente Carolina Morsani , de Sousa Adriana Alckmim , Palomo Juan Martin , Yatabe Marilia , Oliveira Dauro Douglas , Souki Bernardo Quiroga , Andrade Ildeu 
Published: March 2020

ABSTRACTObjectivesTo determine the three-dimensional changes of the nasal septum (NS), alveolar width, alveolar cleft volume, and maxillary basal bone following rapid maxillary expansion (RME) in consecutive patients with unilateral cleft lip and palate (UCLP).Materials and MethodsA retrospective investigation was conducted based on the analysis of cone-beam computed tomography (CBCT) data of 40 consecutive patients with UCLP (mean age 11.1 ± 2.2 years). Scans were acquired prior to RME (T0) and after removal of the expander (T1) before graft surgery. A three-dimensional analysis of the effects of RME on the nasal septum, alveolar width, alveolar cleft volume, and maxillary basal bone was performed.ResultsNo changes in the NS deviation were observed following RME (P &gt; .05). Significant increases of the alveolar transverse dimension were found in the anterior (14.2%; P &lt; .001) and posterior (7.7%; P &lt; .001) regions as well as in the volume of the alveolar cleft (19.6%; P &lt; .001). No changes in the basal bone dimensions and morphology were observed (P &gt; .05).ConclusionsFollowing RME, no changes were observed in the NS and maxillary basal bones of patients with UCLP despite the significant gain in the anterior and posterior alveolar width and the increase of the alveolar cleft defect. Clinicians should be aware that maxillary changes following RME in patients with UCLP are restricted to the dentoalveolar region.
Population Data BC: Supporting population data science in British Columbia
Authors: Ark Tavinder Kaur , Kesselring Sarah , Hills Brent , McGrail Kim 
Published: March 2020

BackgroundPopulation Data BC (PopData) was established as a multi-university data and education resourceto support training and education, data linkage, and access to individual level, de-identified data forresearch in a wide variety of areas including human and community development and well-being.
ApproachA combination of deterministic and probabilistic linkage is conducted based on the quality andavailability of identifiers for data linkage. PopData utilizes a harmonized data request and approvalprocess for data stewards and researchers to increase efficiency and ease of access to linked data.Researchers access linked data through a secure research environment (SRE) that is equipped witha wide variety of tools for analysis. The SRE also allows for ongoing management and control ofdata. PopData continues to expand its data holdings and to evolve its services as well as governanceand data access process.
DiscussionPopData has provided efficient and cost-effective access to linked data sets for research. After twodecades of learning, future planned developments for the organization include, but are not limitedto, policies to facilitate programs of research, access to reusable datasets, evaluation and use of newdata linkage techniques such as privacy preserving record linkage (PPRL).
ConclusionPopData continues to maintain and grow the number and type of data holdings available for research.Its existing models support a number of large-scale research projects and demonstrate the benefitsof having a third-party data linkage and provisioning center for research purposes. Building furtherconnections with existing data holders and governing bodies will be important to ensure ongoingaccess to data and changes in policy exist to facilitate access for researchers.
Un enfoque de estadística espacial para explorar la geodemografía de los ninis en la Zona Metropolitana de la Ciudad de México
Authors: Navarrete Emma Liliana , Trujillo Armando , Garrocho Carlos , Cadena Edel 
Published: March 2020

Utilizamos estadística espacial para examinar la geodemografía de los ninis en la Zona Metropolitana de la Ciudad de México. Hasta donde sabemos, la literatura especializada en ninis no reporta estudios con nuestra aproximación estadística. Exploramos cuatro preguntas clave: ¿Cuántos son? ¿Dónde están? ¿Cómo se explica estadísticamente su distribución espacial? ¿Les afecta la accesibilidad a las oportunidades de empleo y educación? Dado el carácter seminal de nuestro enfoque, abordamos las preguntas con visión socioespacial, pero sin hacer, por ahora, cortes profundos de variables como sexo, nivel escolar y características de su hogar de origen. Los resultados abren nuevos caminos de investigación.
SISTEM FORMULA DAN FUNGSI YANG TERDAPAT DI DALAM SASTRA LISAN MANTAU
Authors: Satria Ridho Pratama 
Published: March 2020

AbstractThis research discusses the formulation system and the functions found in Mantau as one of Jambi’s oral literature. The writer applies the formula’s theory from Parry-Lord and the function’s theory from Alan Dundes. The writer finds two types of formula in Mantau, there are the repetation of words and the use of the name of places around Kerinci. The writer also finds the functions of this oral literature especially for the resident of Lempur Tengah from its lyric.Keywords: oral literature, formula, function, Parry-Lord, Alan Dundes AbstrakPenelitian ini membahas sistem formula dan fungsi-fungsi yang terdapat di dalam salah satu sastra lisan dari Jambi, yaitu sastra lisan Mantau. Teori yang digunakan adalah teori formula dari Parry-Lord serta teori fungsi dari Alan Dundes. Hasil penelitian berupa adanya dua tipe formula di dalam sastra lisan Mantau, yaitu berupa pengulangan kata-kata serta penggunaan nama-nama daerah di sekitar kabupaten Kerinci. Hasil penelitian juga berupa adanya fungsi-fungsi dari sastra lisan Mantau yang diperuntukkan untuk penduduk desa Lempur Tengah. Kata Kunci : sastra lisan, formula, fungsi, Parry-Lord, Alad Dundes