bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kollektive Professionalisierungsprozesse in der Frühen Bildung – Entwicklung des Mandats, der Lizenzierung und der beruflichen Mobilität im Zeitraum 1975 bis 2018 in Westdeutschland
Authors: Grgic Mariana 
Published: April 2020

ZusammenfassungDas Berufsfeld der Kindertagesbetreuung hat in den letzten 50 Jahren eine starke Expansion erfahren, die einen seit 20 Jahren anhaltenden Fachkräftemangel verursacht hat. Gleichzeitig gab es einen Paradigmenwechsel hinsichtlich des gesellschaftlichen Auftrags von Kindertagesbetreuung sowie Ausbildungs- und Gesetzesreformen. Der Beitrag befasst sich mit Professionalisierungsprozessen auf kollektiver Ebene und untersucht auf Basis von professions- und segmentationstheoretischen Ansätzen die Entwicklung des Mandats, der Lizenzierung sowie der beruflichen Mobilität der Beschäftigten im Berufsfeld der Kindertagesbetreuung seit den 1970er-Jahren als spezifische Aspekte beruflicher Regulierung. Ergebnisse einer qualitativen Gesetzesanalyse und Auswertungen der Integrierten Erwerbsbiografien (IEB) des Instituts für Arbeitsmarkt- und Berufsforschung deuten darauf hin, dass eine Homogenisierung des Bildungsmandats stattgefunden hat, aber gleichzeitig das Betreuungsmandat gestärkt wurde. Die berufliche Mobilität ist seit den 1970er-Jahren zurückgegangen, Prozesse der Verfachlichung haben stattgefunden. Allerdings kann der Teilarbeitsmarkt trotz Lizenzierung nur als mäßig geschlossen angesehen werden.
The Effect of Prognostic Communication on Patient Outcomes in Palliative Cancer Care: a Systematic Review
Authors: van der Velden Naomi C. A. , Meijers Maartje C. , Han Paul K. J. , van Laarhoven Hanneke W. M. , Smets Ellen M. A. , Henselmans Inge 
Published: April 2020

Abstract
Background
While prognostic information is considered important for treatment decision-making, physicians struggle to communicate prognosis to advanced cancer patients. This systematic review aimed to offer up-to-date, evidence-based guidance on prognostic communication in palliative oncology.

Methods
PubMed and PsycInfo were searched until September 2019 for literature on the association between prognostic disclosure (strategies) and patient outcomes in palliative cancer care, and its moderators. Methodological quality was reported.

Results
Eighteen studies were included. Concerning prognostic disclosure, results revealed a positive association with patients’ prognostic awareness. Findings showed no or positive associations between prognostic disclosure and the physician-patient relationship or the discussion of care preferences. Evidence for an association with the documentation of care preferences or physical outcomes was lacking. Findings on the emotional consequences of prognostic disclosure were multifaceted. Concerning disclosure strategies, affective communication seemingly reduced patients' physiological arousal and improved perceived physician’s support. Affective and explicit communication showed no or beneficial effects on patients’ psychological well-being and satisfaction. Communicating multiple survival scenarios improved prognostic understanding. Physicians displaying expertise, positivity and collaboration fostered hope. Evidence on demographic, clinical and personality factors moderating the effect of prognostic communication was weak.

Conclusion
If preferred by patients, physicians could disclose prognosis using sensible strategies. The combination of explicit and affective communication, multiple survival scenarios and expert, positive, collaborative behaviour likely benefits most patients. Still, more evidence is needed, and tailoring communication to individual patients is warranted.

Implications
Future research should examine the effect of prognostic communication on psychological well-being over time and treatment decision-making, and focus on individualising care.
Nano-selenium Supplementation Increases Selenoprotein (Sel) Gene Expression Profiles and Milk Selenium Concentration in Lactating Dairy Cows
Authors: Han Liqiang , Pang Kun , Fu Tong , Phillips Clive J. C. , Gao Tengyun 
Published: April 2020

AbstractSupplementation with selenium is common for dairy cows, but the importance of selenium source is not clear. This study aimed to compare nano-selenium (Nano-Se) and sodium selenite supplements for dairy cows on lactation performance, milk Se levels and selenoprotein (Sel) gene expression. Twelve multiparous Holstein cows were randomly divided into two groups: a control group fed a basal diet plus 0.30 mg Se/kg of DM as sodium selenite or Nano-Se for 30 days. Dry matter intake, milk yield and composition were not affected by dietary Se source (P > 0.05); however, the milk total Se levels and milk glutathione peroxidase (GSH-Px) activities were higher with Nano-Se supplementation than sodium selenite (P < 0.05). At the end of the experiment, Nano-Se supplementation significantly increased plasma Se levels and GSH-Px activity, compared with the sodium selenite supplement. The mRNA expression levels of glutathione peroxidase 1, 2 and 4; thioredoxin reductase 2 and 3; and selenoproteins W, T, K and F were markedly upregulated (P < 0.05) in the mammary gland of the Nano-Se group. Thus, the source of selenium plays an important role in the antioxidant status and in particular the Sel gene expression in the mammary glands of dairy cows, both being stimulated by nano sources.
The Significance of Time, Place and Traumatic Experience on at-Risk Youths’ View of their Well-Being: A Preliminary Study
Authors: Exenberger Silvia , Reiber Stefanie 
Published: April 2020

AbstractThis preliminary study explores the perspectives of at-risk youths from different cultural backgrounds on their well-being. We propose that youths’ “well-being awareness” – i.e. what sources of well-being adolescents spontaneously become aware of when they are asked about – is strongly related to their socio-cultural context, their life experiences, and the time when they reflect about it. This study focused on the meaning of well-being sources, which were constructed by youths from different cultural backgrounds who faced different traumatic life experiences. We developed and applied a theoretical framework to understand youths’ well-being awareness. Focus group discussions were analyzed of 48 male youths aged 12–18 years. They either faced the Indian Ocean Tsunami in 2004 (11 boys from South India), or severe intra-familial conflicts (17 European boys), or were unaccompanied minor refugees (20 boys of Asian and African origin). Youths were asked what makes them happy and sad and about their coping strategies, only followed by questions for clarification. First, the data were analyzed inductively based on grounded theory. Second, the gained well-being descriptions were deductively allocated to the most basic elements of human well-being according to White (2008): material, subjective and relational dimension. Through this allocation process the influence of the socio-cultural context (place), life-experience, and time on the meaning of well-being of each youth group became clear. Well-being should be viewed as a process: on the one hand youths conceptions of well-being are deeply rooted in their culture of origin, on the other hand the importance of well-being and its indicators change depending on youths’ traumatic experience and the time of asking about it.
Indications for Emergency Abdominal Surgeries in Older Patients: 7-Year Experience of a Single Centre
Authors: Lebowa Weronika , Skorus Urszula , Rapacz Kamil , Kenig Jakub 
Published: April 2020

AbstractThe majority of patients undergoing emergency laparotomy are older adults that carry the highest mortality. More research into the development of targeted interventions is required. Therefore, the aim of the study was to analyse the indications for emergency abdominal surgery in patients aged ≥ 65 admitted to the Department of General Surgery. The study included consecutive patients aged ≥ 65 who underwent emergency abdominal surgery within 48 h after admission at one institution. In 2010–2017, 986 patients were enrolled in the study (female 57%, male 43%). Patients were divided into three age groups, 65–70, 71–84 and ≥ 85, with 255 patients (25.9%), 562 patients (57.0%) and 169 patients (17.1%) in each group, respectively. In the first and second age groups, the most common indications for surgery were acute cholecystitis, non-malignant ileus, colorectal cancer complications and acute appendicitis. In the oldest patients, the most common indications were complications of colorectal cancer, acute cholecystitis, non-malignant ileus and complications of diverticulosis. In the women, the biggest differences in indications between age groups were colorectal cancer (p = 0.025) and peptic ulcer disease complications (p = 0.005); in the men, the biggest difference was seen for complicated diverticulitis (p = 0.001). The most frequent comorbidities were heart diseases (81.0%), followed by endocrine (33.6%) and vascular diseases (22.7%). The three most common indications for emergency surgery in older patients at our institution were acute cholecystitis, colorectal cancer complications and non-malignant bowel obstruction, affecting 59.5% of this group of patients. Elective surgery and endoscopic screening have the potential to prevent major part of these acute diseases. However, further prospective research is necessary on this field, particularly among frail, older patients.
Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias
Authors: Hadjivassiliou Marios , Graus Francesc , Honnorat Jerome , Jarius Sven , Titulaer Maarten , Manto Mario , Hoggard Nigel , Sarrigiannis Ptolemaios , Mitoma Hiroshi 
Published: April 2020

AbstractAside from well-characterized immune-mediated ataxias with a clear trigger and/or association with specific neuronal antibodies, a large number of idiopathic ataxias are suspected to be immune mediated but remain undiagnosed due to lack of diagnostic biomarkers. Primary autoimmune cerebellar ataxia (PACA) is the term used to describe this later group. An International Task Force comprising experts in the field of immune ataxias was commissioned by the Society for Research on the Cerebellum and Ataxias (SRCA) in order to devise diagnostic criteria aiming to improve the diagnosis of PACA. The proposed diagnostic criteria for PACA are based on clinical (mode of onset, pattern of cerebellar involvement, presence of other autoimmune diseases), imaging findings (MRI and if available MR spectroscopy showing preferential, but not exclusive involvement of vermis) and laboratory investigations (CSF pleocytosis and/or CSF-restricted IgG oligoclonal bands) parameters. The aim is to enable clinicians to consider PACA when encountering a patient with progressive ataxia and no other diagnosis given that such consideration might have important therapeutic implications.
Characterization and potential strategies for the valorisation of the Southwest Atlantic butterfish (Stromateus brasiliensis)
Authors: Ramilo-Fernández Graciela , Sotelo Carmen G. 
Published: April 2020

AbstractThe waste of fish resources constitutes a serious environmental problem that must be avoided. The valorisation of by-catch species and decreasing the discard rate constitute a more efficient and sustainable use of these marine biomasses. In this work, we characterize and propose different potential uses for Stromateus brasiliensis, another frequently discarded (≥ 90%) and poorly studied by-catch species captured in the South Atlantic Ocean (FAO 41) by trawler fishing fleets. Furthermore, in the case of this species, freezing and frozen storage of the whole fish is the only strategy currently employed for its exploitation. The results revealed that muscle from S. brasiliensis presented a high content of polyunsaturated fatty acids (20.34%) and that the concentrations of both total diacyl glyceryl ethers (2.41%) and heavy metals (Hg 0.038, Pb 0.006 and Cd 0.018 mg/kg) were below the established limits for safe human consumption. Likewise, the protein hydrolysates proved to be a good source of amino acids for human consumption or animal feeding. Minced muscle blocks could be made by a mechanical separation process of the flesh, and the composition of minced muscle did not differ much from that of the whole fish. Furthermore, this process allows the incorporation of cryoprotectants and antioxidants to extend the frozen shelf life of this fatty fish. An extraction process from mechanically mixed skin and bones yielded a good source of collagen that should not be neglected.
Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation
Authors: Yang Yunxiang , Yang Pan , Wang Nan , Chen Zhonghao , Su Dan , Zhou Z. Hong , Rao Zihe , Wang Xiangxi 
Published: April 2020

AbstractGenome packaging is a fundamental process in a viral life cycle and a prime target of antiviral drugs. Herpesviruses use an ATP-driven packaging motor/terminase complex to translocate and cleave concatemeric dsDNA into procapsids but its molecular architecture and mechanism are unknown. We report atomic structures of a herpesvirus hexameric terminase complex in both the apo and ADP•BeF3-bound states. Each subunit of the hexameric ring comprises three components—the ATPase/terminase pUL15 and two regulator/fixer proteins, pUL28 and pUL33—unlike bacteriophage terminases. Distal to the nuclease domains, six ATPase domains form a central channel with conserved basic-patches conducive to DNA binding and trans-acting arginine fingers are essential to ATP hydrolysis and sequential DNA translocation. Rearrangement of the nuclease domains mediated by regulatory domains converts DNA translocation mode to cleavage mode. Our structures favor a sequential revolution model for DNA translocation and suggest mechanisms for concerted domain rearrangements leading to DNA cleavage.
Multiple Imputation Ensembles (MIE) for Dealing with Missing Data
Authors: Aleryani Aliya , Wang Wenjia , de la Iglesia Beatriz 
Published: April 2020

AbstractMissing data is a significant issue in many real-world datasets, yet there are no robust methods for dealing with it appropriately. In this paper, we propose a robust approach to dealing with missing data in classification problems: Multiple Imputation Ensembles (MIE). Our method integrates two approaches: multiple imputation and ensemble methods and compares two types of ensembles: bagging and stacking. We also propose a robust experimental set-up using 20 benchmark datasets from the UCI machine learning repository. For each dataset, we introduce increasing amounts of data Missing Completely at Random. Firstly, we use a number of single/multiple imputation methods to recover the missing values and then ensemble a number of different classifiers built on the imputed data. We assess the quality of the imputation by using dissimilarity measures. We also evaluate the MIE performance by comparing classification accuracy on the complete and imputed data. Furthermore, we use the accuracy of simple imputation as a benchmark for comparison. We find that our proposed approach combining multiple imputation with ensemble techniques outperform others, particularly as missing data increases.
Venom-Induced Consumption Coagulopathy Following Hump-Nosed Pit Viper (Genus: Hypnale) Envenoming in Sri Lanka: Uncertain Efficacy of Fresh Frozen Plasma
Authors: Namal Rathnayaka R.M.M.K. , Ranathunga P.E. Anusha Nishanthi , Kularatne S.A.M. 
Published: April 2020

Introduction Hump-nosed pit vipers ( Hypnale spp) cause the highest number of venomous snakebites in Sri Lanka. Bites commonly cause local envenoming leading to local pain, swelling, and necrosis of the site of the bite. Acute kidney injury is the most common systemic manifestation, and some patients develop venom-induced consumption coagulopathy (VICC). Genus Hypnale comprises 3 species. Of them, H hypnale is found in Sri Lanka and the Western Ghats region of India. The other 2 ( H nepa and H zara) are endemic species in Sri Lanka. Methods This study included 500 patients with hump-nosed viper bites studied prospectively over 4.5 y starting June 2014. All patients were assessed and the data were collected by the principal investigator (primary data). A subgroup of patients who developed VICC is described. There were 2 groups, including proven (patients with the specimen of the snake) and probable (specimen of snake not available) bites. Results Thirty (n=500; 6%) patients developed VICC; of them, 17 (3%) were proven cases, and 13 (2%) were probable cases. In both groups, 24 (80%) recovered, 2 (7%) progressed to chronic kidney disease, 1 (3%) died of severe hemostatic dysfunction, and 3 (10%) were lost to follow-up. Systemic bleeding was observed in 16 patients (53%), including hematuria (microscopic and gross) in 8 (27%) and venipuncture bleeding in 5 (17%). Eleven (37%) developed local bleeding at the site of the bite. Fresh frozen plasma was administered to 20 patients (67%), among whom only 11 (55%) experienced early correction of VICC. In both groups, 15 (50%) developed acute kidney injury, and 2 (7%) progressed to chronic kidney disease. Microangiopathic hemolysis was observed in 18 patients (60%) and thrombocytopenia in 16 (53%). Thrombotic microangiopathy was detected in 13 patients (43%), of whom 10 (33%) developed hemolytic uremic syndrome and 2 (7%) had thrombotic thrombocytopenic purpura. Of patients with VICC in the proven group, 94% (n=16) was caused by H hypnale and 1 (6%) was caused by H zara. In the proven group, median international normalized ratio was 3.7 (interquartile range 1.6–5.0); in the probable group, it was 5.0 (interquartile range 2.1–5.4). Conclusions We found that 6% of patients develop hemostatic dysfunction after hump-nosed viper bites. However, which patients will develop coagulopathy or die of envenoming is unpredictable. Reliable and accessible treatments are unmet essential needs because antivenoms for these bites are currently not available in the country. Therapy with fresh frozen plasma has doubtful efficacy in early correction of VICC and needs further evaluation.
Elviniid trilobites from the Elvinia Zone (late Cambrian, Furongian) of Mendoza, western Argentina
Authors: Tortello M. Franco 
Published: April 2020

AbstractIn the 1950s, Carlos Rusconi reported the biostratigraphically important Furongian trilobites Elvinia Walcott and Irvingella Ulrich and Resser from an exotic limestone block (La Cruz Olistolith) of the San Isidro area, Precordillera of Mendoza, western Argentina. Although several local species were erected by Rusconi at that time, most of them were later listed as junior synonyms of E. roemeri (Shumard) or I. major Ulrich and Resser, and this was followed in subsequent studies. A systematic revision of all the available specimens of Elvinia and Irvingella from the Rusconi collection at the Museo de Ciencias Naturales y Antropológicas J.C. Moyano (Mendoza) is provided herein. The occurrence of E. roemeri is supported by the present study, while the associated Irvingella species include I. jorusconii Rusconi, I. platycephala Rusconi, and Irvingella sp. The latter represent “advanced” forms in terms of morphological development in the Irvingella lineage, and these, together with E. roemeri, are typical of the uppermost part of the Elvinia Zone (uppermost Steptoean). Irvingella jorusconii, I. platycephala, and Irvingella sp. appear to be endemic to the Argentinian Precordillera, but are related to species from central Texas and northwest Canada.
A data mining approach to investigate food groups related to incidence of bladder cancer in the BLadder cancer Epidemiology and Nutritional Determinants International Study
Authors: Yu Evan Y. W. , Wesselius Anke , Sinhart Christoph , Wolk Alicja , Stern Mariana Carla , Jiang Xuejuan , Tang Li , Marshall James , Kellen Eliane , van den Brandt Piet , Lu Chih-Ming , Pohlabeln Hermann , Steineck Gunnar , Allam Mohamed Farouk , Karagas Margaret R. , La Vecchia Carlo , Porru Stefano , Carta Angela , Golka Klaus , Johnson Kenneth C. , Benhamou Simone , Zhang Zuo-Feng , Bosetti Cristina , Taylor Jack A. , Weiderpass Elisabete , Grant Eric J. , White Emily , Polesel Jerry , Zeegers Maurice P. A. 
Published: April 2020

AbstractAt present, analysis of diet and bladder cancer (BC) is mostly based on the intake of individual foods. The examination of food combinations provides a scope to deal with the complexity and unpredictability of the diet and aims to overcome the limitations of the study of nutrients and foods in isolation. This article aims to demonstrate the usability of supervised data mining methods to extract the food groups related to BC. In order to derive key food groups associated with BC risk, we applied the data mining technique C5.0 with 10-fold cross-validation in the BLadder cancer Epidemiology and Nutritional Determinants study, including data from eighteen case–control and one nested case–cohort study, compromising 8320 BC cases out of 31 551 participants. Dietary data, on the eleven main food groups of the Eurocode 2 Core classification codebook, and relevant non-diet data (i.e. sex, age and smoking status) were available. Primarily, five key food groups were extracted; in order of importance, beverages (non-milk); grains and grain products; vegetables and vegetable products; fats, oils and their products; meats and meat products were associated with BC risk. Since these food groups are corresponded with previously proposed BC-related dietary factors, data mining seems to be a promising technique in the field of nutritional epidemiology and deserves further examination.
Sleep disturbance mediates the link between childhood trauma and clinical outcome in severe mental disorders
Authors: Laskemoen Jannicke Fjæra , Aas Monica , Vaskinn Anja , Berg Akiah Ottesen , Lunding Synve Hoffart , Barrett Elizabeth Ann , Melle Ingrid , Simonsen Carmen 
Published: April 2020

AbstractBackgroundThe experience of childhood trauma is linked to more severe symptoms and poorer functioning in severe mental disorders; however, the mechanisms behind this are poorly understood. We investigate the relationship between childhood trauma and sleep disturbances in severe mental disorders including the role of sleep disturbances in mediating the relationship between childhood trauma and the severity of clinical symptoms and poorer functioning.MethodsIn total, 766 participants with schizophrenia-spectrum (n = 418) or bipolar disorders (n = 348) were assessed with the Childhood Trauma Questionnaire. Sleep disturbances were assessed through the sleep items in the self-reported Inventory of Depressive Symptoms. Clinical symptoms and functioning were assessed with The Positive and Negative Syndrome Scale and the Global Assessment of Functioning Scale. Mediation analyses using ordinary least squares regression were conducted to test if sleep disturbances mediated the relationship between childhood trauma and the severity of clinical symptoms and poorer functioning.ResultsSymptoms of insomnia, but not hypersomnia or delayed sleep phase, were significantly more frequent in participants with childhood trauma experiences compared to those without. Physical abuse, emotional abuse, and emotional neglect were significantly associated with insomnia symptoms. Insomnia symptoms partly mediate the relationship between childhood trauma and the severity of positive and depressive/anxiety symptoms, in addition to poorer functioning.ConclusionWe found frequent co-occurrence of childhood trauma history and current insomnia in severe mental disorders. Insomnia partly mediated the relationship between childhood trauma and the severity of clinical symptoms and functional impairment.