bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial Raymond–Roy Occlusion Classification but not Packing Density Defines Risk for Recurrence after Aneurysm Coiling
Authors: Greve Tobias , Sukopp Maximilian , Wostrack Maria , Burian Egon , Zimmer Claus , Friedrich Benjamin 
Published: July 2020

Abstract
Purpose
After coil embolization of intracranial aneurysms, it is currently not well understood whether the initial coil packing density or the type of aneurysm residual perfusion, depicted by the modified Raymond-Roy occlusion classification, primarily effects the rate of aneurysm recurrence. We hypothesized that these factors interact and only one remains an independent risk factor.

Methods
In this single center retrospective study, 440 patients with intracranial ruptured and unruptured aneurysms between 2010 and 2017 were screened. A total of 267 patients treated with stand-alone coiling, with or without stent or balloon assistance were included (age 54.1 ± 12.2 years, sex 70.4% female). Flow diverter or Woven EndoBridge (WEB) device implantation were exclusion criteria.

Results
Using a binary logistic regression model, independent risk factors for aneurysm recurrence were postinterventional modified Raymond-Roy occlusion classification class (Odds ratio [OR] 1.747, 95% confidence interval [CI] 1.231–2.480) and aneurysm diameter (OR 1.145, CI 1.032–1.271). A trend towards a higher recurrence in ruptured aneurysms did not reach significance (OR 1.656, CI 0.863–3.179). Aneurysm localization, packing density, and neck width were not independently associated with aneurysm recurrence.

Conclusion
Independent risk factors for aneurysm recurrence after coil embolization with and without stent or balloon assistance were aneurysm diameter and postinterventional grading within the modified Raymond-Roy occlusion classification. Packing density interacted with the latter and was not independently associated to recurrence.
Creation of fertility-restored materials for Ogura CMS in Brassica oleracea by introducing Rfo gene from Brassica napus via an allotriploid strategy
Authors: Yu Hai-long , Li Zhi-yuan , Ren Wen-jing , Han Feng-qing , Yang Li-mei , Zhuang Mu , Lv Hong-hao , Liu Yu-mei , Fang Zhi-yuan , Zhang Yang-yong 
Published: July 2020

AbstractKey messageOgura CMS fertility-restored materials, with 18 chromosomes, normal seed setting, stable fertility and closer genetic background to the parent Chinese kale, were successfully developed inB. oleraceavia a triploid strategy for the first time.AbstractOgura cytoplasmic male sterility (CMS) is the most widely used sterile type in seed production for commercial hybrids ofBrassica oleraceavegetables. However, the natural Ogura CMS restorer line has not been found inB. oleraceacrops. In this study, the triploid strategy was used with the aim to create euploidB. oleraceaprogenies with theRfogene. The allotriploid AAC hybrid YL2 was used as a male parent to backcross with Ogura CMS Chinese kale. After successive backcrosses, the BC2Rfo-positive individual 16CMSF2-11 and its BC3progenies, with 18 chromosomes, were developed, which were morphologically identical to the parent Chinese kale. Compared with F1and BC1plants, it showed stable fertility performance, and regular meiosis behavior and could produce seeds normally under natural pollination. The genomic composition analysis ofRfo-positive progenies by using molecular markers showed that more than 87% of the C-genome components of BC3Rfo-progenies recovered to the parent Chinese kale, while most or all of theAn-genome segments were lost in 16CMSF2-11 and its progenies. The results suggested that the genetic background ofRfo-positive individuals was closer to that of the parent Chinese kale along with backcrossing. Hereof, the Ogura CMS fertility-restored materials of Chinese kale were successfully created via triploid strategy for the first time, providing a bridge for utilizing the Ogura CMSB. oleraceagermplasm in the future. Moreover, our study indicates that the triploid strategy is effective for transferring genes fromB. napusintoB. oleracea.
Method development for on-line species-specific sulfur isotopic analysis by means of capillary electrophoresis/multicollector ICP-mass spectrometry
Authors: Faßbender Sebastian , Rodiouchkina Katerina , Vanhaecke Frank , Meermann Björn 
Published: July 2020

AbstractIn this work, a method for species-specific isotopic analysis of sulfur via capillary electrophoresis hyphenated on-line with multicollector ICP-MS (CE/MC-ICP-MS) was developed. Correction for the mass bias caused by instrumental mass discrimination was realized via external correction with multiple-injection sample-standard bracketing. By comparing the isotope ratio measurement results obtained using the newly developed on-line CE/MC-ICP-MS method with those obtained via traditional MC-ICP-MS measurement after analyte/matrix separation by anion exchange chromatography for isotopic reference materials and an in-house bracketing standard, the most suitable data evaluation method could be identified. The repeatability for the sulfate-δ34S value (calculated from 18 measurements of a standard conducted over seven measurement sessions) was 0.57‰ (2SD) and thereby only twice that obtained with off-line measurements (0.30‰, n = 68). As a proof of concept for analysis of samples with a real matrix, the determination of the sulfur isotopic composition of naturally present sulfate was performed for different river systems. The CE/MC-ICP-MS results thus obtained agreed with the corresponding off-line MC-ICP-MS results within the 2SD ranges, and the repeatability of consecutive δ34S measurements (n = 3) was between 0.3‰ and 1.3‰ (2SD). Finally, the isotopic analysis of two different S-species in a river water sample spiked with 2-pyridinesulfonic acid (PSA) was also accomplished.
Examples of smooth components of moduli spaces of stable sheaves
Authors: Reede Fabian , Zhang Ziyu 
Published: July 2020

AbstractLetMbe a projective fine moduli space of stable sheaves on a smooth projective varietyXwith a universal family$${\mathcal {E}}$$E. We prove that in four examples,$${\mathcal {E}}$$Ecan be realized as a complete flat family of stable sheaves onMparametrized byX, which identifiesXwith a smooth connected component of some moduli space of stable sheaves onM.
Functional diversity of reef molluscs along a tropical-to-temperate gradient
Authors: Floyd Matthew , Mizuyama Masaru , Obuchi Masami , Sommer Brigitte , Miller Mark GR , Kawamura Iori , Kise Hiroki , Reimer James D. , Beger Maria 
Published: July 2020

AbstractGlobal warming is leading to range shifts of marine species, threatening the structure and functioning of ecological communities and human populations that rely on them. The largest changes are seen in biogeographic transition zones, such as subtropical reef communities, where species range shifts are already causing substantial community reorganisation. This causes functional changes in communities over subtropical latitudes, though a baseline functional understanding remains elusive for many taxa. One key marine taxon are molluscs, which provide many ecosystem services, are important prey for fishes and are also fisheries targets themselves, but remain largely unstudied. Here, we examine the trait composition, functional diversity, and functional redundancy of mollusc assemblages along the tropical-to-temperate transition in Japan (25° to 35° Northern latitude). Specifically, we use a trait database of 88 mollusc species from 31 subtropical reefs along the Pacific coast of Japan to show that trait composition of mollusc assemblages changes continuously along the latitudinal gradient. We discover that functional diversity of mollusc assemblages decreases with increasing latitude, a pattern associated with declines in functional dispersion. Moreover, we find a clear distinction between tropical and subtropical mollusc assemblages, with substrate-attached, suspension feeding bivalves more abundant in the tropics and free-living gastropod grazers more prevalent at higher latitudes. Our trait-based evidence in this study shows a contraction and almost complete shift in the functioning of marine mollusc assemblages at biogeographic transition zones and our trait database facilitates further study. Our findings provide evidence of the changing taxonomic and functional composition of extant mollusc communities with latitude, pointing to potential pertinent changes and tropicalisation of these communities with rapid ocean warming.
Einseitige Optikusatrophie bei einem 9-jährigen Patienten
Authors: Nguyen-Höhl Anna , Khattab Mohammed H. , Henneke Marco , Feltgen Nicolas , Hoerauf Hans , Bemme Sebastian 
Published: July 2020

ZusammenfassungEin 9‑jähriger Patient stellte sich aufgrund einer seit 2 Wochen zufällig bemerkten Sehminderung auf dem linken Auge vor. Funduskopisch waren neben einer leichten Vitritis eine blasse Papille, enggestellte Gefäße und eine Reflexvermehrung der Netzhautoberfläche sichtbar. In der Blutuntersuchung waren die Werte bis auf eine Eosinophilie und einen erhöhten Immunglobublin E(IgE)-Antikörpertiter normal.
Evaluating the didactic value of 3D visualization in otosurgery
Authors: Weiss Nora M. , Schneider Armin , Hempel John M. , Uecker Florian C. , van Bonn Sara M. , Schraven Sebastian P. , Rettschlag Stefanie , Schuldt Tobias , Müller Joachim , Plontke Stefan K. , Mlynski Robert 
Published: July 2020

Abstract
Introduction
Improvements of surgical visualization add value to the quality of clinical routine and offer the opportunity to improve surgical education of medical staff. The aim of this study was to determine whether otorhinolaryngology trainees gain additional comprehension of the anatomical structures and the surgical site when 3D visualization is used.

Methods
Data were collected from ENT trainees of microsurgical courses of the middle ear, inner ear and lateral skull base at four university ENT departments (Charité (Berlin), Martin Luther University Halle-Wittenberg (Halle/Saale), Ludwig Maximilian University (Munich) and Rostock University Medical Center). Participants were asked to complete a questionnaire assessing the subjective value of identical surgical field visualization in 3D for surgeon and observer.

Results
A total of 112 participants completed the questionnaire. The majority of participants stated a high additional value of 3D visualization compared to 2D visualization, with 75% fully agreeing to the statement that 3D visualization of the surgical field is superior to perceive the anatomical topography and structures compared to 2D representation. Participants encouraged the storage of data in online learning platforms.

Conclusion
The results show that 3D visualization with identical imaging for surgeon and observer is a useful tool in teaching of microsurgery. It addresses perception of anatomical topography and structures as well as conception of the surgical workflow.
Apomorphine formulation may influence subcutaneous complications from continuous subcutaneous apomorphine infusion in Parkinson’s disease
Authors: Hagell Peter , Höglund Arja , Hellqvist Carina , Johansson Eva-Lena , Löwed Berit , Sjöström Anne-Christine , Karlberg Carina , Lundgren Margareth , Dizdar Nil , Johansson Anders , Willows Thomas , Rådberg Johan , Bergquist Filip 
Published: July 2020

AbstractContinuous subcutaneous (s.c.) apomorphine infusion is an effective therapy for Parkinson’s disease (PD), but a limitation is the formation of troublesome s.c. nodules. Various chemically non-identical apomorphine formulations are available. Anecdotal experiences have suggested that shifting from one of these (Apo-Go PumpFill®; apoGPF) to another (Apomorphine PharmSwed®; apoPS) may influence the occurrence and severity of s.c. nodules. We, therefore, followed 15 people with advanced PD (median PD-duration, 15 years; median “off”-phase Hoehn and Yahr, IV) on apoGPF and with troublesome s.c. nodules who were switched to apoPS. Data were collected at baseline, at the time of switching, and at a median of 1, 2.5, and 7.3 months post-switch. Total nodule numbers (P < 0.001), size (P < 0.001), consistency (P < 0.001), skin changes (P = 0.058), and pain (P ≤ 0.032) improved over the observation period. PD severity and dyskinesias tended to improve and increase, respectively. Apomorphine doses were stable, but levodopa doses increased by 100 mg/day. Patient-reported apomorphine efficacy tended to increase and all participants remained on apoPS throughout the observation period; with the main patient-reported reason being improved nodules. These observations suggest that patients with s.c. nodules caused by apoGPF may benefit from switching to apoPS in terms of s.c. nodule occurrence and severity. Alternatively, observed benefits may have been due to the switch itself. As nodule formation is a limiting factor in apomorphine treatment, a controlled prospective study comparing local tolerance with different formulations is warranted.
Automated simulation of voxel-based microstructures based on enhanced finite cell approach
Authors: Fangye Yannick F. , Miska Niklas , Balzani Daniel 
Published: July 2020

AbstractA new and efficient method is proposed for the decomposition of finite elements into finite subcells, which are used to obtain an integration scheme allowing to analyse complex microstructure morphologies in regular finite element discretizations. Since the geometry data of reconstructed microstructures are often given as voxel data, it is reasonable to exploit the special properties of the given data when constructing the subcells, i.e. the perpendicularly cornered shape of the constituent interfaces at the microscale. Thus, in order to obtain a more efficient integration scheme, the proposed method aims to construct a significantly reduced number of subcells by aggregating as much voxels as possible to larger cuboids. The resulting methods are analysed and compared with the conventional Octree algorithm. Eventually, the proposed optimal decomposition method is used for a virtual tension test on a reconstructed three-dimensional microstructure of a dual-phase steel, which is afterwards compared to real experimental data.
Muscle pain induced by hypertonic saline in the knee extensors decreases single-limb isometric time to task failure
Authors: Smith Samuel A. , Micklewright Dominic , Winter Samantha L. , Mauger Alexis R. 
Published: July 2020

Abstract
Purpose
Increased nociceptive activity and the experience of exercise-induced pain (EIP) may contribute to fatigue during endurance exercise. To investigate this, a pain model that produces pain similar to EIP and decouples its relationship to exercise intensity is required. This study (1) compared the quality of pain caused by a hypertonic saline injection into the vastus lateralis in resting and exercise conditions, and (2) investigated whether this pain contributes to changes in time to task failure.

Methods
On separate days, 18 participants completed a time to task failure at 20% maximal voluntary torque (MVT), a resting hypertonic saline intramuscular injection, and in a further three visits a time to task failure at 10% MVT following injection of isotonic saline, hypertonic saline or a control (no injection).

Results
In a subset of eligible participants (n = 12), the hypertonic saline combined with 10% MVT produced a qualitative experience of pain (assessed by the McGill Pain Questionnaire) that felt similar to EIP. 10% MVT with hypertonic saline significantly elevated pain intensity in the first 20% of the time to task failure and caused a significantly (P < 0.05) shorter time to task failure (448 ± 240 s) compared with the isotonic saline (605 ± 285 s) and control (514 ± 197 s) conditions.

Conclusion
These findings demonstrate that hypertonic saline increases the intensity of pain during exercise, which results in a faster occurrence of exercise-induced fatigue. These results provide important evidence supporting pain as a limiting factor in endurance performance.
Quality of life and mortality after surgical treatment for vertebral osteomyelitis (VO): a prospective study
Authors: Yagdiran Ayla , Otto-Lambertz Christina , Lingscheid Kristina Michaela , Sircar Krishnan , Samel Christina , Scheyerer Max Joseph , Zarghooni Kourosh , Eysel Peer , Sobottke Rolf , Jung Norma , Siewe Jan 
Published: July 2020

Abstract
Purpose
Vertebral osteomyelitis (VO) has a high mortality and leads to chronic pain and functional disability. Surgical treatment is often necessary. To date, little is known about the consequences of surgery on patient outcome. The aim of this study was to determine the quality of life (QoL) and mortality rates of surgically treated VO patients for a period of 2 years.

Methods
Patients with VO undergoing surgical treatment in a tertiary referral hospital from 2008 to 2015 were included prospectively. Data were collected before (T0) as well as 1 year (T1) and 2 years (T2) post-surgery. Within the European Spine Tango registry, prospective patient and QoL data were collected using validated outcome scores: Oswestry Disability Index, Short Form 36/EuroQol, Visual Analog Scale, and Core Outcome Measures Index.

Results
From 195 patients surgically treated for VO, QoL data were available from 136 patients at T0, 100 patients at T1, and 82 patients at T2, respectively. The 1- and 2-year mortality rates were 20% and 23%. Mainly all QoL outcome scores showed significant improvement at T1 and did not change significantly from T1 to T2.

Conclusion
Surgical treatment of VO patients leads to significantly improved QoL. Nevertheless, QoL levels were below those of the general population. Our results underscore that spine disability questionnaires measuring QoL are mandatory to demonstrate comprehensively the severity of this entity. Our study confirms a high mortality and points out the role of VO as a potentially life-threatening condition.
Gestalt descriptions for deep image understanding
Authors: Hörhan Markus , Eidenberger Horst 
Published: July 2020

AbstractIn this work, we present a novel visual perception-inspired local description approach as a preprocessing step for deep learning. With the ongoing growth of visual data, efficient image descriptor methods are becoming more and more important. Several local point-based description methods were defined in the past decades before the highly accurate and popular deep learning methods such as convolutional neural networks (CNNs) emerged. The method presented in this work combines a novel local description approach inspired by the Gestalt laws with deep learning, and thereby, it benefits from both worlds. To test our method, we conducted several experiments on different datasets of various forensic application domains, e.g., makeup-robust face recognition. Our results show that the proposed approach is robust against overfitting and only little image information is necessary to classify the image content with high accuracy. Furthermore, we compared our experimental results to state-of-the-art description methods and found that our method is highly competitive. For example it outperforms a conventional CNN in terms of accuracy in the domain of makeup-robust face recognition.
Is there an unmet medical need for palliative care services in Germany? Incidence, prevalence, and 1-year all-cause mortality of palliative care sensitive conditions: real-world evidence based on German claims data
Authors: Gothe H. , Brinkmann C. , Schmedt N. , Walker J. , Ohlmeier C. 
Published: July 2020

Abstract
Aim
To characterize palliative care patients, to estimate the incidence, prevalence, and 1-year all-cause mortality in patients in Germany who received palliative care treatment.

Subject and methods
The study analyzed the InGef Research Database, which covers 4 million people insured in German statutory health insurance companies. Specific outpatient and inpatient reimbursement codes were used to capture cases with palliative conditions. The prevalence was ascertained for the year 2015. The incidence was calculated for patients without documented palliative care services in the year before the observation period. The Kaplan–Meier method was used to analyze the 1-year all-cause mortality.

Results
The incidence rate of palliative conditions was 41.3 and 34.9 per 10,000 persons in women and men, respectively. The prevalence per 10,000 persons was 61.3 in women and 51.1 in men. The 1-year all-cause mortality among patients receiving their first palliative care treatment was 67.5%. Mortality was lower in patients receiving general outpatient palliative care treatment (AAPV; 60.8%) compared to patients receiving specialized outpatient palliative care treatment (SAPV; 86.1%) or inpatient palliative care treatment (90.6%). Within the first 30 days, mortality was particularly high (~43.0%).

Conclusions
In Germany, more than 400,000 patients per year receive palliative care treatment, which is lower compared to estimates of the number of persons with a potential need for palliative care. This gap was observed particularly in younger to middle-aged individuals. The findings indicate a demand for methodologically sound studies to investigate the public health burden and to quantify the unmet need for palliative care in Germany.
Estrogen, progesterone, and human epidermal growth factor receptor 2 discordance between primary and metastatic breast cancer
Authors: Walter Vincent , Fischer Chiara , Deutsch Thomas M. , Ersing Catherine , Nees Juliane , Schütz Florian , Fremd Carlo , Grischke Eva-Maria , Sinn Peter , Brucker Sara Y. , Schneeweiss Andreas , Hartkopf Andreas D. , Wallwiener Markus 
Published: July 2020

Abstract
Background
The estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) statuses are frequently discordant between the primary tumor and metastatic lesions in metastatic breast cancer. This can have important therapeutic implications.

Patients and methods
In all, 541 patients with available receptor statuses from both primary tumor and metastatic lesion treated at Heidelberg and Tuebingen University Hospitals between 1982 and 2018 were included.

Results
Statistically significant discordance rates of 14% and 32% were found for ER and PR. HER2 status was statistically insignificantly discordant in 15% of patients. Gain in HER2 positivity was associated with an improved overall survival, whereas loss of HR positivity was associated with worse overall survival. Antiendocrine treatment differed in 20% of cases before and after biopsy and HER2-directed treatment in 14% of cases.

Conclusions
Receptor statuses are discordant between primary tumor and metastasis in a considerable fraction of patients with metastatic breast cancer. Next to a highly presumed predictive value with respect to efficacy of endocrine and HER2-targeted therapy, discordance seems to provide prognostically relevant information. Where feasible, metastatic lesions should be biopsied in accordance with current guidelines.
Confessions without guilt: public confessions of state violence in Turkey
Authors: Yıldız Yeşim Yaprak , Baert Patrick 
Published: July 2020

AbstractDrawing on Austin’s speech act theory and on related theories of performativity and positioning, this article analyses the public confessions during the 1990s by three prominent state actors in Turkey about their direct involvement in state crimes against Kurds and left-wing political opponents. All three cases received significant media attention at the time. The aim of the article is not only to shed new light on those specific confessions by the perpetrators within the Turkish context, but also to develop further theoretical insights into the phenomenon of public confessions as such. Whilst confessions of this kind are often welcomed and portrayed as truth-statements that are cathartic and enable society to move forward, this analysis demonstrates that the reality is often more complex as the confessions in question tend to go hand in hand with a disavowal of individual responsibility by the perpetrators involved.