bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Gold(I) and Palladium(II) Complexes Bearing N‐Heterocyclic Carbene Thioglucosides with Selective Cytotoxicity Towards Ovarian Cancer Cells
Authors: Bru Francis , Vanwynsberghe Maxime , Botter Eleonora , Tonon Giovanni , Visentin Fabiano , Schiavo Alessia , Rizzolio Flavio , Cazin Catherine S. J. , Scattolin Thomas 
Published: December 2024

AbstractWe report the development of an efficient and versatile synthetic protocol for the preparation of gold(I) and palladium(II) complexes bearing N‐heterocyclic carbene (NHC) thioglucosides and their azolium precursors. Gold(I) and Nolan‐type palladium(II)‐allyl complexes were synthesized under mild aerobic conditions using potassium carbonate as a base. Additionally, allyl palladate complexes were prepared via a straightforward solvent‐free method. In vitro assays on three ovarian cancer cell lines (OVCAR‐5, A2780, and its cisplatin‐resistant clone A2780cis) revealed interesting structure‐activity relationships (SARs). Gold(I) complexes with saturated NHC ligands showed enhanced activity, while Nolan‐type palladium(II)‐allyl complexes with unsaturated NHC ligands exhibited higher efficacy. Allyl palladates demonstrated similar activity regardless of whether the ligand was saturated or not. The most promising compounds display high selectivity for cancer cells, with cytotoxicity comparable to cisplatin on A2780 and OVCAR‐5 lines and superior activity against the A2780cis line. Notably, these compounds showed minimal toxicity towards non‐cancerous MRC‐5 cells. This selective anticancer activity is likely due to the presence of glucoside units, suggesting their role as targeting agents.
Outcome of IWGT workshop on transcriptomic biomarkers for genotoxicity: Key considerations for bioinformatics
Authors: Meier Matthew J. , Caiment Florian , Corton J. Christopher , Frötschl Roland , Fujita Yurika , Jennen Danyel , Mezencev Roman , Yauk Carole 
Published: December 2024

AbstractAs a part of the International Workshop on Genotoxicity Testing (IWGT) in 2022, a workgroup was formed to evaluate the level of validation and regulatory acceptance of transcriptomic biomarkers that identify genotoxic substances. Several such biomarkers have been developed using various molecular techniques and computational approaches. Within the IWGT workgroup on transcriptomic biomarkers, bioinformatics was a central topic of discussion, focusing on the current approaches used to process the underlying molecular data to distill a reliable predictive signal; that is, a gene set that is indicative of genotoxicity and can then be used in later studies to predict potential DNA damaging properties for uncharacterized chemicals. While early studies used microarray data, a technological shift occurred in the past decade to incorporate modern transcriptome measuring techniques such as high‐throughput transcriptomics, which in turn is based on high‐throughput sequencing. Herein, we present the workgroup's review of the current bioinformatic approaches to identify genes comprising transcriptomic biomarkers. Within the context of regulatory toxicology, the reproducibility of a given analysis is critical. Therefore, the workgroup provides consensus recommendations on how to facilitate sufficient reporting of experimental parameters for the analytical procedures used in a transcriptomic biomarker study, including the recommendation to develop a biomarker‐specific reporting module within the OECD Omics Reporting Framework.
Faux Feminisms: Why feminism is a fight against oppression, not an individual cause
Authors: Arnett Autumn A. 
Published: December 2024

In her forthcoming book, Faux Feminisms: Why We Fall for White Feminism and How We Can Stop, Jay Newman Chair in Philosophy of Culture at Brooklyn College, NY, and Professor of Philosophy and Women's and Gender Studies at the CUNY Graduate Center Serene Khader sets out to reframe the feminist movement as one for the collective advancement of all women.
A Modified Strain‐Wedge Model for Small Strain Rigid Piles in Sand
Authors: Yin Yisheng , Wang Dongyuan , Cui Kai 
Published: December 2024

ABSTRACTThis paper develops a modified strain‐wedge (MSW) model that accounts for the resistance to bending moments caused by the lateral frictional resistance and axial forces of piles in the small‐strain regime in sands and algorithmizes a finite differential analysis program. Two cases of rigid pile tests, one in Blessington and another in Shenton Park were used to calibrate the finite element analysis model and verify the proposed modified model. The results show that the analysis of pile‐side resistance is pivotal for rigid horizontally loaded monopiles, and the MSW model is the most accurate at predicting lateral displacement and the moments. Its accuracy in a small‐strain regime to predict the pile rotation points and the maximum bending moment is almost three times that of other models. With the increase of the soil strain, the accuracy of the MSW decreases. On the contrary, the prediction accuracy of numerical analysis using the UBC3D‐PLM constitutive model increases.
Analytical Derivations and Numerical Verifications on the Asymmetric Dynamic Responses of the Buried Steel Pipelines Under Seismic Active Faults
Authors: Yang Denglian , Luo Zhongya , Li Zhaochao 
Published: December 2024

ABSTRACTThe seismic ground movements may lead to significant bending, tensile, and compressive strains to the buried steel pipelines. This study concerns the dynamic behavior of the buried pipeline at its yielding state to offer preliminary design criteria in the geohazard region. An analytical scheme is proposed to assess the responses of the pipelines under a normal fault or a strike‐slip fault. A piecewise function is assumed to describe the deformed S‐shaped pipeline under the seismic fault. Then, the explicit strain and displacement are obtained by considering the asymmetry of curvature and pipeline‐soil interaction. Moreover, the deformed length and yield displacement are predicted explicitly based on the first yielding theory of the classical beam for both asymmetric and symmetric cases. In addition, the proposed analytical results, characterized by the deformed shape and the yield displacement, are verified efficiently by developing a three‐dimensional (3D) finite element model (FEM) in the present study, as well as other predictions elsewhere. It is found that the present study offers a good reference for strength evaluation and failure analysis of pipelines subjected to a normal fault or a strike‐slip fault.
The Spatial Organization of Ascending Auditory Pathway Microstructural Maturation From Infancy Through Adolescence Using a Novel Fiber Tracking Approach
Authors: Lynch Kirsten M. , Bodison Stefanie C. , Cabeen Ryan P. , Toga Arthur W. , Voelker Courtney C. J. 
Published: December 2024

ABSTRACTAuditory perception is established through experience‐dependent stimuli exposure during sensitive developmental periods; however, little is known regarding the structural development of the central auditory pathway in humans. The present study characterized the regional developmental trajectories of the ascending auditory pathway from the brainstem to the auditory cortex from infancy through adolescence using a novel diffusion MRI‐based tractography approach and along‐tract analyses. We used diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) to quantify the magnitude and timing of auditory pathway microstructural maturation. We found spatially varying patterns of white matter maturation along the length of the tract, with inferior brainstem regions developing earlier than thalamocortical projections and left hemisphere tracts developing earlier than the right. These results help to characterize the processes that give rise to functional auditory processing and may provide a baseline for detecting abnormal development.
Fibroblast growth factor receptor four inhibitor FGF401 improves the efficacy of trastuzumab in FGFR4‐overexpressing breast cancer cells
Authors: Cheng Tzu‐Chun , Huang Bu‐Miin , Liao You‐Cheng , Chang Han‐Sheng , Tu Shih‐Hsin , Ho Yuan‐Soon , Chen Li‐Ching 
Published: December 2024

AbstractBreast cancer is the most common cancer among women. Among them, human epidermal growth factor receptor‐positive (HER2+) breast cancer is more malignant. Fortunately, many anti‐HER2 drugs are currently used in clinical treatments to increase patient survival. However, some HER2+ patients (~15%) still develop drug resistance after receiving trastuzumab treatment, leading to treatment failure. Using CCLE and METABRIC database analyses, we found that fibroblast growth factor receptor 4 (FGFR4) mRNA was highly detected in tumors from HER2+ breast cancer patients (p < .001) and was associated with poorer survival in breast cancer patients. Through retrospective immunohistochemical staining analysis, we detected higher expression of FGFR4 protein in breast cancer tissues collected from patients who were resistant to trastuzumab therapy compared with breast cancer patients who responded to treatment. An FGFR4 inhibitor (FGF401) effectively inhibits tumor growth in trastuzumab‐insensitive patient‐derived xenograft (PDX) tumor‐bearing mice. For molecular mechanism studies, we demonstrated that HER2/FGFR4 protein complexes were detected on the cell membrane of the tumor tissues in these trastuzumab‐insensitive PDX tumor tissues. After trastuzumab treatment in these drug‐resistant breast cancer cells, FGFR4 translocates and enters the nucleus. However, trastuzumab‐induced nuclear translocation of FGFR4/HER2‐intracellular domain protein complex in trastuzumab‐resistant cancer cells is blocked by FGF401 treatment. We believe that FGFR4 overexpression and complex formation with HER2 can serve as molecular markers to assist clinicians in identifying trastuzumab‐resistant tumors. Our results suggest that FGF401 combined with trastuzumab as adjuvant therapy for patients with trastuzumab‐resistant breast cancer may be a potential new treatment strategy.
Pulsed Red Photobiomodulation Boosts the Inhibition of Oxytocin‐Induced Primary Dysmenorrhea in Mice by Suppressing Oxidative Stress and Inflammation
Authors: Fu Qiqi , Yang Jiali , Jiang Hui , Ren Yi , Huo Longfei , Liu Muqing 
Published: December 2024

ABSTRACTIncreasing evidence has underscored the pivotal role of red photobiomodulation (R‐PBM) in analgesic and anti‐inflammatory processes; nonetheless, research concerning the effects of pulsed wave on primary dysmenorrhea (PD) remains sparse. This study found that pulsed R‐PBM significantly diminished pain responses and levels of PGF2α/PGE2, mitigated uterine swelling, augmented antioxidant capacity, and lowered MDA concentrations, which outperformed continuous wave at the same average irradiance. Furthermore, PW treatment substantially reduced ROS levels and enhanced cell viability in PGF2α induced HUSM cells. NOS levels, especially iNOS, were markedly diminished in the uteri of PD mice, accompanied by significant alterations in inflammation‐related genes (Jun, Fos, IL1rn, IL17b) and protein levels, along with pronounced downregulation of calcium ion concentrations after pulsed R‐PBM intervention. These findings indicated that pulsed R‐PBM may mitigate pain by modulating ROS and NO/NOS, mediated oxidative stress and inflammatory responses. Consequently, pulsed R‐PBM emerges as a promising therapeutic strategy for PD.
Assessment of Microcirculation and Microrheological Parameters of Blood in Patients With Type 2 Diabetes Mellitus Using Biophotonics Techniques
Authors: Umerenkov D. A. , Ermolinskiy P. B. , Lugovtsov A. E. , Fabrichnova A. A. , Gurfinkel Yu. I. , Dyachuk L. I. , Priezzhev A. V. 
Published: December 2024

ABSTRACTIn this study, the parameters of blood microcirculation and microrheology were measured using the methods of laser aggregometry and optical tweezers in vitro, as well as the method of digital capillaroscopy in vivo. It was shown that in patients suffering from type 2 diabetes mellitus, an increase in the number of RBC aggregates passing through the narrow capillaries leads to a significant decrease in the velocity of the capillary blood flow, which can be explained by the increased viscosity of the whole blood and decreased deformability of RBCs. Also, for the group of patients, a statistically significant increase in the rate of RBC aggregation and the hydrodynamic strength of aggregates, RBC aggregation and disaggregation forces were observed compared to the control group. We have demonstrated the possibility of using these methods to assess changes in microrheological and microcirculatory parameters of the blood.
Peaking Today, Taking It Easy Tomorrow: Daily Performance Dynamics of Working Long Hours
Authors: ten Brummelhuis Lieke L. , Calderwood Charles , Rosen Christopher C. , Gabriel Allison S. 
Published: December 2024

ABSTRACTUnderlying the “ideal worker” image that pervades many organizational cultures is the assumption that working longer hours equates to higher performance, despite recovery research that suggests that long work hours might actually impair future work performance. In an effort to reconcile these differences in how long work hours are thought to relate to job performance, we develop and test a conceptual model in which daily boosts in same‐day performance associated with working longer hours could be offset by lower next‐day performance. More specifically, we examine if working a longer day than usual reduces sleep, which has the potential to diminish physical (i.e., physical energy) and psychological (i.e., resilience) resources the next morning, consequently impairing next‐day work performance. In a 5‐day experience sampling study of 67 employee–coworker dyads (276 days), using sleep data from a wearable device (i.e., Fitbit) in combination with daily self‐report surveys and coworker performance ratings, results indicated that daily work hours were positively related to same‐day work performance. Our results further indicated that work hours were negatively related to next‐day work performance through reduced sleep duration and morning resilience, but not through diminished physical energy. Together, our findings indicate that although employees may experience same‐day performance gains related to working long hours, they also may pay a price the following day, as longer workdays prevent employees from recovering overnight.
Flexible bezel‐less thin‐film transistor backplane with through‐plastic‐vias for seamless tiling
Authors: Tsuji Hiroshi , Miyakawa Masashi , Takei Tatsuya , Fujisaki Yoshihide , Nakata Mitsuru 
Published: December 2024

AbstractTiling with a variety of panel units is a promising approach to customizing displays in terms of size, shape, and aspect ratio. However, tiled displays with conventional panel units have a major drawback in that they suffer from noticeable seams due to the bezels of the panel units. Here, we demonstrate a flexible bezel‐less thin‐film transistor (TFT) backplane for seamless tiling. By using through‐plastic‐vias (TPVs) that penetrate an ultrathin polyimide (PI) film substrate, a bezel‐less backplane with an ultra‐narrow bezel width of 8 μm was realized, in which oxide TFTs in pixel circuits on the backplane are driven from the back side of the PI film substrate using three‐dimensional signal wires, which go through the TPVs. The resistance of a TPV was evaluated with a TPV chain with 1000 TPVs connected in series and was found to be as small as 1.3 Ω. Furthermore, the transfer characteristics of an oxide TFT in a test element group for a pixel circuit were evaluated from the back side of the PI film substrate. The TFT exhibited clear switching behavior with an on/off current ratio of more than 108 and a high mobility of 25 cm2/Vs, which are sufficient to drive light‐emitting devices.
Explicit Symmetry Breaking of Generalized Angular Momentum by Second‐Harmonic Generation in Underdense Plasmas
Authors: Voisine Alexis , Béjot Pierre , Billard Franck , Marroux Hugo , Faucher Olivier , Hertz Edouard 
Published: December 2024

AbstractLight beams possess two intrinsic quantized degrees of freedom, related to spin angular momentum (SAM) and orbital angular momentum (OAM), whose manipulation enables extensive control over the topological properties of electromagnetic fields. In this context, structured fields constructed from a non‐separable combination of SAM and OAM have recently gained sustained interest. Such states are eigenstates of the so‐called generalized angular momentum (GAM), a mixed angular momentum operator encompassing both SAM and OAM components, which can result in astonishing fractional eigenvalues. The demonstration of GAM conservation under harmonic generation has suggested a potential relevance of this new form of angular momentum as a meaningful quantum number. In the present work, the scope of evaluation is expanded by investigating its conservation law with second‐harmonic generation in an underdense isotropic inhomogeneous plasma that relies on dipole‐forbidden interaction implying spin‐orbit coupling. This study reveals that the symmetry and topological properties of the field are disrupted during the nonlinear process, the GAM charge being only conserved on average. This symmetry breaking can be exploited to provide an easily detectable signature of the driving field topology or to create a robust topological attractor.
Tensile Properties of Epoxy Composites Filled With Graphene Nanoplatelets and PUF Microcapsules
Authors: Nascimento Ana Paula , Ribeiro Cesar G. , Zoschke Gustavo H. , Njuguna James , Pezzin Sergio H. 
Published: December 2024

AbstractThis work evaluates the effect of poly(urea‐formaldehyde) (PUF) microcapsules filled with aminated polydimethylsiloxane (PDMS‐a), a self‐healing agent, on the tensile properties of epoxy composites reinforced with graphene nanoplatelets (GNP). The microcapsules are produced by interfacial polymerization and later are infiltrated with the healing agent (PDMS‐a). GNP are dispersed in epoxy resin using sonication, followed by the addition of hollow or filled PUF microcapsules to the system, using mechanical stirring, just before the addition of the curing agent (hardener). The mixture is then cast in soft molds to produce specimens for tensile tests. The results show that the presence of 1 wt% GNP changes the properties of the composites with an improvement in tensile strength and modulus, which achieves 37.4 MPa and 2.8 GPa, respectively, in comparison with neat epoxy and specimens containing just microcapsules. The addition of 2 wt% GNP, however, impairs these properties, with tensile strength and Young's modulus decreasing to 24.9 MPa and 2.3 GPa, due to the presence of GNP agglomerates. The presence of the microcapsules, however, decreases the immediate (no self‐healing) tensile performance of the composites.
Using mark–recapture techniques to evaluate catch and release, recycling, and associated survival probabilities of stocked Muskellunge at two Ohio reservoirs
Authors: Page Kevin S. , Wagner Curtis P. , Lewis Edward 
Published: December 2024

Abstract

Objective
Muskellunge Esox masquinongy fisheries in Ohio are almost exclusively catch and release. Catch and release is expected to benefit anglers via recaptures of previously caught fish (i.e., recycling). We used mark–recapture techniques to evaluate catch-and-release dynamics over multiple years in two stocked Muskellunge fisheries in Ohio.

Methods
Muskellunge were collected and tagged each spring by the Ohio Department of Natural Resources, Division of Wildlife (ODNR-DOW) at Clearfork Reservoir (1991–2006) and Leesville Lake (2016–2022). A total of 4139 Muskellunge were tagged, of which 38% (n = 1575) were recaptured at least once by either the ODNR-DOW or anglers. A total of 252 anglers reported 1339 catches of tagged fish. Multistate modeling was used to estimate survival and transition probabilities across years for the following marked fish states: at large (L, ODNR-DOW marked fish not reported caught by anglers); catch and release (C, those fish reported caught and released by anglers); and recycled (R, catch-and-release fish caught and reported by anglers again). Transition probabilities between states L to C and C to R estimated Muskellunge catch and release and recycling, respectively.

Result
Raw angler catch reports indicated that intra-annual recycling was rare, with the median time between recapture events exceeding a year. Modeled annual survival probability of L fish at Clearfork Reservoir and Leesville Lake was 0.67 and 0.87, respectively. About a quarter of these fish were caught and released by anglers at both reservoirs. Survival of C fish was lower than L fish at both reservoirs (Clearfork Reservoir = 0.58; Leesville Lake = 0.67), suggesting a “catch-and-release effect” on survival. Joint probability of catch-and-release fish surviving and being recycled annually was 0.24 and 0.23 for Clearfork Reservoir and Leesville Lake, respectively.

Conclusion
Integration of survival and catch probabilities over the long-term provides a comprehensive evaluation of catch-and-release dynamics. Estimates suggest that post-catch-and-release survival and probability of recycling may be lower than anticipated, which may have implications for managing Muskellunge fisheries and angler expectations.
Abiotic and biotic factors related to growth of nonnative Walleyes in Lake Pend Oreille, Idaho
Authors: Frawley Susan E. , Corsi Matthew P. , Dux Andrew M. , Hardy Ryan S. , Quist Michael C. 
Published: December 2024

Abstract

Objective
Understanding factors influencing growth is vital to effective management of fish populations. This study investigated potential factors influencing growth of an established nonnative population of Walleyes Sander vitreus in the Lake Pend Oreille system in northern Idaho.

Methods
We used relative growth index to describe growth of Walleyes relative to populations across North America. Mixed-effects modeling was used to relate growth to abiotic (i.e., mean summer water temperature, river inflow) and biotic (i.e., kokanee Oncorhynchus nerka abundance and biomass; opossum shrimp Mysis diluviana density) variables. Models were ranked using Akaike's information criterion corrected for small sample size. Individual variability in growth was related to diet represented by stable isotopes (i.e., δ15N, δ13C) using linear regression for age-1, age-2, age-3, and age-5 individuals. Subsequently, for each age-class, we evaluated differences in δ15N and δ13C between fast-growing (i.e., 75th and higher percentiles of growth) and slow-growing (i.e., 25th and lower percentiles of growth) individuals.

Result
Walleyes grew fast relative to other populations. Growth of Walleyes was positively associated with temperature as well as abundance and biomass of kokanee; growth was unrelated to river inflow and opposum shrimp density. The top model indicated that growth of Walleyes was related to temperature and kokanee abundance. An equally plausible model explaining growth consisted of only temperature. Generally, fast-growing Walleyes exhibited higher δ15N than slow-growing individuals. Similarly, δ13C was more depleted in the fast-growing individuals for all ages except age 1. This suggests that fast-growing individuals likely consumed prey items at higher trophic positions and fast-growing Walleyes (except age 1) used higher proportions of pelagic prey items.

Conclusion
This study showed that kokanee abundance and temperature likely influenced growth of Walleyes in the Lake Pend Oreille system. Additionally, variability in growth was apparently related to variability in diet, particularly for age-1 Walleyes.