bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of latex wound models for the wound dressing training of nursing students
Authors: Bannaasan Benyaporn 
Published: August 2020

A model is an essential instrument for the practical training of nursing students before field training in the ward, and an aid which creates skill and confidence for the students. The objective of this research is to develop a latex wound model for the wound dressing training of nursing students. Three research procedures are 1) to study documents and data relating to the development of latex wound models, 2) to construct the latex wound models and the research instruments, and 3) to try out the latex wound models, and evaluate the latex wound models efficiency. Participants are the 60 second-year nursing students. A wet dressing type latex wound model efficiency evaluation form and a dry dressing type latex wound model efficiency evaluation form were used for data collection. A reliability of 0.884 and 0.889 was acquired. The data were analyzed using descriptive statistics and Wilcoxon Signed Ranks Test. The finding of the studying results indicated that the mean scores of efficiency of both invented wet dressing type and dry dressing type latex wound model were higher than that of the original wound model of the Faculty of Nursing at statistical significance (p < .05). The finding indicated that the latex wound model had higher quality than those of the original wound model. Also, it helps the Faculty of Nursing save budget on purchasing expensive models.
Développement hydroélectrique québécois
Authors: Fréchette Camille 
Published: August 2020

Cet article s’intéresse à la question du droit au consentement préalable, libre et éclairé (CPLE) dans le contexte de l’industrie hydroélectrique québécoise et à l’important rôle énergétique et économique qu’elle joue pour la province. En l’absence de législation spécifiquement axée sur la mise en oeuvre de la Déclaration des Nations unies sur les droits des peuples autochtones (DNUDPA) au Québec, l’auteur analyse les dynamiques relationnelles entre Hydro-Québec et les nations crie et innue afin de vérifier dans quelle mesure les composantes et pratiques de l’industrie hydroélectrique peuvent permettre à elles seules de favoriser une mise en oeuvre adéquate du droit au CPLE. L’article révèle enfin l’absence de normes et de pratiques capables de garantir l’obtention d’un véritable CPLE et illustre une longueur d’avance dans la qualité du consentement obtenu chez les Cris d’Eeyou Istchee, en comparaison avec les Innus de la Côte-Nord. Des recommandations quant à la mise en oeuvre du CPLE font suite à ces constats.
Forgotten Values
Authors: Kramarz Teresa 
Published: August 2020

An examination of the conflict between values and bureaucracy in World Bank biodiversity partnerships.
Multi-stakeholder partnerships have become an increasingly common form of global governance. Partnerships, usually between international organizations (IOs) or state agencies and such private actors as NGOs, businesses, and academic institutions, have even been promoted as the gold standard of good governance—participatory, innovative, and well-funded. And yet these partnerships often fail to live up to the values that motivated their establishment. In this book, Teresa Kramarz examines this gap between promise and performance by analyzing partnerships in biodiversity conservation initiatives launched by the World Bank.
Kramarz reviews World Bank biodiversity partnerships over a twenty-year period, with in-depth studies of two: the Critical Ecosystem Partnership Fund and the Global Invasive Species Program. She finds that partnerships fall short when established in the shadow of a large, mature bureaucracy. Bureaucrats have trouble relinquishing control, and they distrust partners who do not abide by set policies and procedures. The partnership's potential contribution to biodiversity conservation succumbs to the goals of bureaucratic efficiency. Kramarz develops a theoretical framework to explain the gap between values and practice, combining rationalist and constructivist approaches. Viewing World Bank biodiversity partnerships through this theoretical lens, she shows how the World Bank's risk aversion, hierarchy, focus on rules and procedures, and division of labor have a significant influence on partnership outcomes.
The role of textiles as fomites in the healthcare environment: a review of the infection control risk
Authors: Owen Lucy , Laird Katie 
Published: August 2020

Background
Infectious diseases are a significant threat in both healthcare and community settings. Healthcare associated infections (HCAIs) in particular are a leading cause of complications during hospitalisation. Contamination of the healthcare environment is recognised as a source of infectious disease yet the significance of porous surfaces including healthcare textiles as fomites is not well understood. It is currently assumed there is little infection risk from textiles due to a lack of direct epidemiological evidence. Decontamination of healthcare textiles is achieved with heat and/or detergents by commercial or in-house laundering with the exception of healthcare worker uniforms which are laundered domestically in some countries. The emergence of the COVID-19 pandemic has increased the need for rigorous infection control including effective decontamination of potential fomites in the healthcare environment. This article aims to review the evidence for the role of textiles in the transmission of infection, outline current procedures for laundering healthcare textiles and review studies evaluating the decontamination efficacy of domestic and industrial laundering.

Methodology
Pubmed, Google Scholar and Web of Science were searched for publications pertaining to the survival and transmission of microorganisms on textiles with a particular focus on the healthcare environment.

Results
A number of studies indicate that microorganisms survive on textiles for extended periods of time and can transfer on to skin and other surfaces suggesting it is biologically plausible that HCAIs and other infectious diseases can be transmitted directly through contact with contaminated textiles. Accordingly, there are a number of case studies that link small outbreaks with inadequate laundering or infection control processes surrounding healthcare laundry. Studies have also demonstrated the survival of potential pathogens during laundering of healthcare textiles, which may increase the risk of infection supporting the data published on specific outbreak case studies.

Conclusions
There are no large-scale epidemiological studies demonstrating a direct link between HCAIs and contaminated textiles yet evidence of outbreaks from published case studies should not be disregarded. Adequate microbial decontamination of linen and infection control procedures during laundering are required to minimise the risk of infection from healthcare textiles. Domestic laundering of healthcare worker uniforms is a particular concern due to the lack of control and monitoring of decontamination, offering a route for potential pathogens to enter the clinical environment. Industrial laundering of healthcare worker uniforms provides greater assurances of adequate decontamination compared to domestic laundering, due to the ability to monitor laundering parameters; this is of particular importance during the COVID-19 pandemic to minimise any risk of SARS-CoV-2 transmission.
CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia
Authors: Liu Weiwei , Wang Yan , Qiu Zhimei , Zhao Ranzun , Liu Zhijiang , Chen Wenming , Ge Junbo , Shi Bei 
Published: August 2020

Background
The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia. Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are involved in the regulation of physiological and pathophysiological processes. CircHIPK3 has been identified as the one of the most crucial regulators in cardiac fibrosis. However, the mechanisms by which circHIPK3 regulates cardiac fibrosis under hypoxia remain unclear. Our study aimed to determine circHIPK3 expression in cardiac fibroblasts (CFs) and investigate the functions of circHIPK3 in hypoxia environment.

Methods
The expression level of circHIPK3 in CFs under hypoxia (1% O2) was analyzed by qRT-PCR. The role of circHIPK3 on the proliferation and migration of CFs were determined by EdU, cell wound scratch assay and cell cycle. The expression of proteins associated with phenotypic transformation in CFs in vitro was examined by immunofluorescence assay and western blot. Bioinformatics analysis, dual luciferase activity assay and RNA fluorescent in situ hybridization assay revealed that miR-152-3p was identified as a target of circHIPK3 and that TGF-β2 was targeted by miR-152-3p.

Results
CircHIPK3 expression was significantly upregulated in CFs in a hypoxic environment. In vitro, overexpressing circHIPK3 obviously promoted CF proliferation, migration and phenotypic changes under hypoxia, but those processes were suppressed by circHIPK3 silencing. CircHIPK3 acted as an endogenous miR-152-3p sponge and miR-152-3p aggravated circHIPK3 silencing induced inhibition of CF proliferation, migration, phenotypic transformation and TGF-β2 expression in vitro. In summary, circHIPK3 plays a pivotal role in the development of cardiac fibrosis by targeting the miR-152-3p/TGF-β2 axis.

Conclusions
These findings demonstrated that circHIPK3 acted as a miR-152-3p sponge to regulate CF proliferation, migration and phenotypic transformation through TGF-β2, revealing that modulation of circHIPK3 expression may represent a potential target to promote the transition of hypoxia-induced CFs to myofibroblasts.
Distribution characteristics of serum β2-microglobulin between viral and bacterial lower respiratory tract infections: a retrospective study
Authors: Cai Xulong , Xu Qiaolan , Zhou Chenrong , Zhou Li , Yong Qijun , Mu Qing , Cheng Yan , Wang Jiena , Xie Jingjing 
Published: August 2020

Background
Lower respiratory tract infection (LRTI) is one of the leading cause of death in children under 5 years old around the world between 1980 and 2016. Distinguishing between viral and bacterial infection is challenging when children suffered from LRTI in the absence of pathogen detection. The aim of our study is to analyze the difference of serum β2-microglobulin (β2-MG) between viral LRTI and bacterial LRTI in children.

Methods
This retrospective study included children with LRTI caused by a single pathogen from Yancheng Third People’s Hospital, Yancheng, China, between January 1, 2016 and December 31, 2019. Participants were divided into the younger group (1 year old ≤ age < 3 years old) and the older group (3 years old ≤ age < 5 years old) for subgroup analysis.

Results
A total of 475 children with LRTI caused by common respiratory pathogens were identified. In the younger group as well as the older group, the serum level of β2-MG in respiratory syncytial virus, influenza A virus and influenza B virus groups were significantly increased compared to that in the Mycoplasma pneumoniae group. Compared with Streptococcus pneumoniae infection group, the serum β2-MG level of respiratory syncytial virus, influenza A virus and influenza B virus groups were significantly higher in children between 1 and 3 years old.

Conclusions
The serum β2-MG may distinguish viral infection from bacterial infection in children with LRTI.
Drosera stipularis, a new species for the D. petiolaris complex from Cape York Peninsula, Queensland
Authors: Baleeiro Paulo C , Jobson Richard W , Barrett Russell L 
Published: August 2020

Across tropical northern Australia 14 Drosera species are recognised within the D. petiolaris complex. The complex is placed in section Lasiocephala; a group of perennial sundews mostly characterised by an indumentum of white hairs upon the petiole. Here we describe a new species for the complex, D. stipularis
Baleeiro, R.W.Jobson & R.L.Barrett, which is known only from white-sand habitats on Cape York Peninsula, Queensland. The new species is allied to D. petiolaris R.Br. ex DC. and D. lanata K.Kondo.
The Effectiveness of the Use of Aquatic Plants (Lemna perpusilla, Landoltia punctata and Azolla pinnata) in the Phytoremediation Process of Catfish Aquaculture Wastewater
Authors: Amyati . , Hasan Zahidah , Supriadi Dedi , Hamdani Herman 
Published: August 2020

Aims: The purpose of this study was to determine aquatic plants (Lemna perpusilla, Landoltila punctata and Azolla pinnata) that have the most effective ability as phytoremediation agents for catfish cultivation wastewater.
Study Design: This research was conducted by an experimental method, with a Completely Randomized Design (CRD) consisting of three treatments and four replications.
Place and Duration of Study: This research is located at the Wet Laboratory (Ciparanje) of the Faculty of Fisheries and Marine Sciences, Padjadjaran University. Water quality testing is carried out at the Water Resources Laboratory of the Faculty of Fisheries and Marine Sciences. Research was carried out on 20 July-24 September 2019.
Methodology: The test wastewater was collected from catfish pond culture and put into twelve aquarium with a volume of 8 litre. Physical and chemical parameters observed include BOD5, dissolved oxygen, CO2 acidity, temperature, nitrate, and phosphate.
Results: Lemna perpusilla, Landoltia punctata and Azolla pinnata were able to improve the quality of catfish culture wastewater such as increasing the concentration of dissolved oxygen (DO) and pH, and reducingBOD5, CO2, nitrate and phosphate. Lemna perpusilla was able to reduce the concentration of BOD5, CO2,carbondioxide, nitrate and phosphate from catfish cultivation wastewater by75%; 77.7%; 23.4%; 44.2%, respectively, during the phytoremediation process, and Landoltia punctata was able to reduce the concentrations same parameters by 52%; 68.3%; 17.8%; 18.3% and Azolla pinnata by 41%; 84%; 15.3% and 28.4%.
Conclusion: Lemnaper pusillamay improve the quality of catfish culture wastewater better than Landoltia punctata and Azolla pinnata. Lemna perpusilla can be recommended as phytoremediation agents catfish cultivation wastewater to remediate organic matter before being discharged directly into water bodies.
Zopiclone in the treatment of insomnia in depressed patients
Authors: Van Moffaert M , Pilate C 
Published: July 2002

SummaryDuring the early treatment of a major depressive episode with amitryptiline, insomnia was treated in 81 patients in a double-blind comparative trial comparing zopiclone and flunitrazepam. The study showed no major differences in the efficacy profile and showed better tolerability for zopiclone than for flunitrazepam.
Acute fatty liver and HELLP syndrome: two distinct pregnancy disorders
Authors: Vigil‐De Gracia P. 
Published: July 2002

AbstractObjective: to report the experience clinical, biochemical findings, complications and the maternal–perinatal outcome in patients with HELLP syndrome and acute fatty liver of pregnancy (AFLP) during the same period. Materials and methods: during the period between January 1996 and December 1999, medical records of patients with the discharge diagnosis of AFLP and HELLP syndrome were reviewed for presenting symptoms, laboratory findings, maternal and perinatal complications. Routine laboratory evaluation included serial measurement of liver function tests, complete blood cell count, coagulation profile and renal function tests. Results: during the study period 10 patients had AFLP and 75 women had HELLP syndrome as the discharge diagnosis. Patients with HELLP syndrome had major parity than AFLP (P<0.006). The most common presenting symptom for patients with AFLP was malaise noted in all patients, nausea and/or vomiting, abdominal pain and jaundice were very common. Headache, abdominal or epigastric pain and hematuria were the most common symptoms of patients with HELLP syndrome. Women with AFLP had major hypoglycemia, hypocholesterolemia, hypotriglyceridemia, serum transaminase activity and low antithrombin III. Disseminated intravascular coagulation, acute renal insufficiency, ascites, seroma and encephalophaty were more common with AFLP. Conclusions: our opinion is that AFLP had clinical presentation, biochemical findings and complications clearly distinguished of HELLP syndrome.
Techniques for improving response rates in OM survey research
Authors: Frohlich Markham T 
Published: July 2002

AbstractResponse rates are an important indicator of survey research success and a methodological concern in OM today. An analysis was done of 233 OM survey research papers published over the past 12 years which showed that the average managerial response rate flattened‐out in the mid‐1990s at, approximately 32% and has not improved since then. This paper goes on to examine the theories and techniques found in the diverse survey research literature on improving response rates including OM survey research benchmarks that achieved very high response rates. By following the tactics outlined in this paper, OM survey researchers stand an excellent chance of not only improving the overall respondent yields for their studies but also reducing the bias caused by non‐response.
Analysis of cerebrocortical neuronal migration in three‐dimensional fetal mouse cerebral explants: comparison with in vivo
Authors: Humphreys Peter , Hendelman Walter 
Published: July 2002

AbstractOrganotypic cultures of cerebral mantle offer a useful method for in vitro investigation of mechanisms involved in the migration of neuronal precursors to the neocortex. Studies reported to‐date have indicated that, while neurons continue to migrate in cerebral explant cultures for a few days, they eventually stop migrating and fail to reach their pre‐programmed destinations and thus distinct layers fail to develop within the cortical plate. Hypothesizing that this migrational arrest stemmed, in part, from severe distortion and flattening of explants in the roller‐tube culture method used in previous studies by others, we studied neocortical neuronal migration using a recently developed three‐dimensional explant culture system. Explants 300–350 μm thick were derived from E16 fetal mouse cerebrum 24 h following administration of 5‐bromodeoxyuridine (BrdU), encased in collagen, placed on porous membranes, and alternately exposed to medium and air on a rocking platform. Cultures were maintained for 7, 11 and 14 days, then analyzed for the location of BrdU‐labeled cells. Newborn mice labeled at E15 and analyzed at P1 and P9 served as controls. In the explants, labeled cells continued to migrate into the cortical plate until 11 days in culture, at which point the ventricular zone had disappeared and two distinct cortical cell layers sometimes developed. BrdU‐labeled cells were present throughout the cortical plate, particularly the mid portion. In P9 controls, five distinct cortical layers were present with labeled cells mostly in the outer half (layers II, III). Thus, preservation of three‐dimensional tissue integrity in culture was accompanied by a modest improvement in migration of neurons to the neocortex in comparison with previous reports. The fact that normal layer formation failed to develop in thick explants suggests that factors other than tissue distortion contribute to this outcome.
Viktor Hamburger's Department of Zoology in the 1940s: a student perspective
Authors: Wenger Byron S. , Wenger Eleanor 
Published: July 2002

AbstractEleanor and Byron Wenger were graduate students in the Department of Zoology in the 1940s. Both took several courses with Viktor, and he was thesis advisor for both of us. We have attempted to provide a summary of life in the department from a student perspective as well as our impression of Viktor's style of mentoring and guiding student research and education.
Developmentally induced microencephalopathy in guinea pigs ‐embryonic glial cell activation marks selective neuronal death
Authors: Roßner Steffen , Brückner Martina K. , Bigl Volker 
Published: July 2002

AbstractWe have recently shown that in utero treatment of guinea pigs with the DNA methylating substance methylazoxymethanol acetate (MAM) on gestation day (GD) 24 results in neocortical microencephalopathy, increased protein kinase C activity and altered processing of the amyloid precursor protein in neocortex of the offsprings. In order to identify the primary neuronal lesions produced by MAM‐treatment, we mapped the 5‐bromo‐2’‐deoxyuridine (BrdU)‐incorporation in dividing neurons on GD 24 and we followed the effects of MAM‐treatment on GD 24 on embryonic immediate early gene expression and on glial cell activation. BrdU injected on GD 24 labeled many neurons of the ventricular zone and of the intermediate zone but only scattered neurons of the cortical plate. When time‐mated guinea pigs were injected intraperitoneally with MAM on GD 24, we observed the activation of microglial cells in the ventricular/intermediate zone and the appearence of astrocytes between the intermediate zone and the cortical plate, 48 h after intoxification. The activation of glial cells was accompanied by the neuronal expression of c‐Fos but not of c‐Jun in the ventricular/intermediate zone. Based on our observations on BrdU‐incorporation and on the morphological outcome of MAM treatment in the juvenile guinea pig, our data presented here indicate that selective neurodegeneration during development induces the activation of both phagocytotic microglial cells and of astrocytes which might trophically support damaged neurons surviving this lesion procedure.
Evidence that the loss of Purkinje cells and deep cerebellar nuclei neurons in homozygous weaver is not related to neurogenetic patterns
Authors: Martı́ Joaquı́n , Wills Katherine V. , Ghetti Bernardino , Bayer Shirley A. 
Published: July 2002

AbstractTo determine whether the neurogenetic patterns of Purkinje cells and deep cerebellar nuclei neurons were normal in weaver homozygotes and whether the degeneration of those neuronal types was linked to their time of origin, [3H] thymidine autoradiography was applied on sections of homozygous weaver mice and normal controls on postnatal day 90. The experimental animals were the offspring of pregnant dams injected with [3H] thymidine on embryonic days 11–12, 12–13, 13–14 and 14–15. The results show that the onset of neurogenesis, its pattern of peaks and valleys, and its total span were similar between wild type and homozygous weaver in the cerebellar areas analyzed, indicating that the loss of Purkinje cells and deep cerebellar nuclei neurons is not related to neurogenetic patterns. In weaver homozygotes, the loss of Purkinje cells and deep cerebellar nuclei neurons followed a lateral to medial gradient of increasing severity. Thus, the vermis and the fastigial nucleus, which are medially located, presented the most important neuron loss, whereas in the lateral hemisphere and the dentate nucleus, neuron loss was spared.
Behaviour of gliomas in vitro vs histopathological grading
Authors: de Ridder L. 
Published: July 2002

AbstractInfiltration of primary cultured human gliomas into host tissue in vitro is correlated to the histological grade of tumours they are derived from. The higher the malignancy grade, following the WHO classification, the higher the number of tumours expressing an infiltrative pattern in vitro. To select the putative infiltrative cells from freshly collected brain tumour material, tumour fragments are explanted in vitro and primary monolayers are grown. From these cultures flaps of viable and proliferating tumour‐derived cells are placed in contact with embryonic host tissue forming a confrontation culture. If infiltrative cells are present in the monolayer, they will infiltrate into the host tissue and replace it in a progressive way: they express an infiltrative pattern. If no infiltrative cells are present, host and tumour‐derived cells will stay together expressing a noninfiltrative pattern.So analysis of the confrontation pattern in vitro observed for individual gliomas, collected by a stereotactic biopsy, might help the neurosurgeon to set up a surgical strategy.