bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semi-Recumbent Vibration Exercise in Older Adults: A Pilot Study of Methodology, Feasibility, and Safety
Authors: Taani Murad H. , Siglinsky Ellen , Libber Jessie , Krueger Diane , Binkley Neil , Kovach Christine R. , Buehring Bjoern 
Published: October 2019

Objectives: Older adults with impaired physical function are at risk for further functional decline in part due to limited ability to engage in regular exercise. Effective approaches to exercise in this vulnerable population are needed to improve functional capacity and optimize independence. Methods: Thirty-two residential care apartment complex (RCAC) residents, age ≥70, with low short physical performance battery (SPPB) scores were recruited and randomly assigned to a crossover-design study exploring feasibility and safety of semi-recumbent vibration exercise in older adults living in one RCAC. The primary outcomes were retention and adherence rates and adverse events. Results: The retention rate was 78%. Adherence rate was 79.7% and 78.6% during the vibration and control training sessions, respectively. Thirty-eight adverse events (AEs) occurred. Mild muscle soreness and knee pain were the only AEs related to vibration exercise. No serious adverse events (SAEs) were study-related. Participants were able to increase training intensity and load and rated the training enjoyable. Conclusion: Semi-recumbent vibration exercise was feasible, well tolerated, and safe in RCAC residents with reduced physical function. Future studies need to examine the effect of this type of exercise on physical function, mobility, falls, and quality of life.
Generation and function of progenitor T cells from StemRegenin-1–expanded CD34+ human hematopoietic progenitor cells
Authors: Singh Jastaranpreet , Chen Edward L. Y. , Xing Yan , Stefanski Heather E. , Blazar Bruce R. , Zúñiga-Pflücker Juan Carlos 
Published: October 2019

Key Points
CD34+CD7+ as well as CD34−CD7+ cells from SR1-expanded CD34+ HSPCs are effective thymus-reconstituting cells in vivo. CD7+ cells derived from SR1-expanded CD34+ HSPCs generate functional and polyclonal T-cell repertoires in vivo.
Occurrence, thromboembolic risk, and mortality in Danish patients with cold agglutinin disease
Authors: Bylsma Lauren C. , Gulbech Ording Anne , Rosenthal Adam , Öztürk Buket , Fryzek Jon P. , Arias Jaime Morales , Röth Alexander , Berentsen Sigbjørn 
Published: October 2019

Key PointsThis is the first study to compare thromboembolism and mortality risk in CAD against a general population cohort. Patients with CAD were at a significantly increased risk of death, especially during the first 5 years after diagnosis.
Viscoelastic creep behavior of surface- and inner-layers of sugi boxed-heart timber under various temperatures
Authors: Hermawan Andi , Fujimoto Noboru 
Published: October 2019

Abstract
This study was conducted to investigate the rheological behavior of sugi boxed-heart timber under constant moisture content (MC) using a cantilever creep test. The focus of the study was the effect of temperature on viscoelastic creep behavior of surface- and inner-layer specimens of the timber. The specimens with dimensions of 75 mm in length, 25 mm wide, and 3 mm thick were prepared. A cantilever creep test with an effective span of 40 mm was conducted under a constant temperature of 20, 65, 80, and 95 °C. The equilibrium moisture content (EMC) of the specimens was set to around 12% at each temperature. A load representing 20% of rupture load of the specimens at each temperature was applied to their free-end and strain gauges were bonded at the fourth span (10 mm) on the upper and bottom surfaces of the specimens. Loading and unloading duration were set for 300 and 180 min, respectively, and a four-element Burgers model was used to model the creep behavior of the timber. It was found that temperature had significant effects on the creep properties of the timber. The surface strain and creep compliance of the surface- and inner-layer specimens tended to increase as the temperature increased. Creep compliance of the surface-layer specimen was higher than that of the inner-layer specimen at each temperature. Fitting the experimental data with the Burgers model used in this study shows good agreement and it was found that elastic (instantaneous) and viscoelastic (delayed) creep compliance of all the specimens tended to increase as the temperature increased. On the other hand, the viscosity of the dashpot element of both the Maxwell and the Kelvin unit tended to decrease as the temperature increased. Although different in magnitude, the creep-recovery compliance parameters had the same tendency as the creep compliance parameters.
Vocabulary comprehension in adults with fragile X syndrome (FXS)
Authors: Hoffmann Anne , Krause Sue Ellen , Wuu Joanne , Leurgans Sue , Guter Stephen J. , Block Sandra S. , Salt Jeff , Cook Edwin , Maino Dominick M. , Berry-Kravis Elizabeth 
Published: October 2019

Abstract

Background
Receptive and expressive vocabulary in adult and adolescent males with fragile X syndrome (FXS) have been shown as significantly lower than their chronological age; however, receptive vocabulary has been considered a strength relative to mental age. This has not been formally examined, however, and data are needed to compare receptive vocabulary with other language skills and with mental age in individuals with FXS. This is especially important as vocabulary measures are sometimes used as a proxy to estimate language ability.

Methods
This preliminary study examined receptive vocabulary, global language, and cognitive skills in 42 adults (33 males and 9 females) with FXS as a portion of the baseline evaluation prior to randomization in a clinical trial of ampakine CX516. The battery of standardized tests addressed receptive vocabulary with the Peabody Picture Vocabulary Test, Third Edition (PPVT-III), receptive and expressive language (termed henceforth as global language) via the Preschool Language Scale, Fourth Edition or the Clinical Evaluation of Language Fundamentals, Third Edition, and non-verbal cognition via the Stanford-Binet Intelligence Scales, Fourth Edition (SB-IV).

Results
Results showed (1) significantly higher receptive vocabulary than global language, (2) significantly better receptive vocabulary than non-verbal cognition, (3) equivalent non-verbal cognition and global language, and (4) severity of autism symptomatology was not correlated to receptive vocabulary or global language once non-verbal cognition was removed as factor. The scores from the PPVT-III did not represent the global language skills in our sample of adults with FXS.

Conclusions
Findings from this investigation strongly suggest that the PPVT-III should not be used as a screening tool for language levels or cognitive function in clinical studies since the scores from the PPVT-III were not representative of global language or non-verbal cognitive skills in adults with intellectual disabilities. This finding is critical in order to understand how to evaluate, as well as to treat, language in individuals with FXS. Development of efficient and appropriate tools to measure language, cognition, and behavior in individuals with FXS is essential.
Genome-wide characterization and expression analysis of the HD-Zip gene family in response to drought and salinity stresses in sesame
Authors: Wei Mengyuan , Liu Aili , Zhang Yujuan , Zhou Yong , Li Donghua , Dossa Komivi , Zhou Rong , Zhang Xiurong , You Jun 
Published: October 2019

AbstractBackgroundThe homeodomain-leucine zipper (HD-Zip) gene family is one of the plant-specific transcription factor families, involved in plant development, growth, and in the response to diverse stresses. However, comprehensive analysis of the HD-Zip genes, especially those involved in response to drought and salinity stresses is lacking in sesame (Sesamum indicumL.), an important oil crop in tropical and subtropical areas.ResultsIn this study, 45 HD-Zip genes were identified in sesame, and denominated as SiHDZ01-SiHDZ45. Members of SiHDZ family were classified into four groups (HD-Zip I-IV) based on the phylogenetic relationship ofArabidopsisHD-Zip proteins, which was further supported by the analysis of their conserved motifs and gene structures. Expression analyses ofSiHDZgenes based on transcriptome data showed that the expression patterns of these genes were varied in different tissues. Additionally, we showed that at least 75% of theSiHDZgenes were differentially expressed in responses to drought and salinity treatments, and highlighted the important role of HD-Zip I and II genes in stress responses in sesame.ConclusionsThis study provides important information for functional characterization of stress-responsive HD-Zip genes and may contribute to the better understanding of the molecular basis of stress tolerance in sesame.
Whole-genome DNA similarity and population structure of Plasmodiophora brassicae strains from Canada
Authors: Sedaghatkish Afsaneh , Gossen Bruce D. , Yu Fengqun , Torkamaneh Davoud , McDonald Mary Ruth 
Published: October 2019

AbstractBackgroundClubroot is an important disease of brassica crops world-wide. The causal agent,Plasmodiophora brassicae,has been present in Canada for over a century but was first identified on canola (Brassica napus) in Alberta, Canada in 2003. Genetic resistance to clubroot in an adapted canola cultivar has been available since 2009, but resistance breakdown was detected in 2013 and new pathotypes are increasing rapidly. Information on genetic similarity among pathogen populations across Canada could be useful in estimating the genetic variation in pathogen populations, predicting the effect of subsequent selection pressure on changes in the pathogen population over time, and even in identifying the origin of the initial pathogen introduction to canola in Alberta.ResultsThe genomic sequences of 43 strains (34 field collections, 9 single-spore isolates) ofP. brassicaefrom Canada, the United States, and China clustered into five clades based on SNP similarity. The strains from Canada separated into four clades, with two containing mostly strains from the Prairies (provinces of Alberta, Saskatchewan, and Manitoba) and two that were mostly from the rest of Canada or the USA. Several strains from China formed a separate clade. More than one pathotype and host were present in all four Canadian clades. The initial pathotypes from canola on the Prairies clustered separately from the pathotypes on canola that could overcome resistance to the initial pathotypes. Similarly, at one site in central Canada where resistance had broken down, about half of the genes differed (based on SNPs) between strains before and after the breakdown.ConclusionClustering based on genome-wide DNA sequencing demonstrated that the initial pathotypes on canola on the Prairies clustered separately from the new virulent pathotypes on the Prairies. Analysis indicated that these ‘new’ pathotypes were likely present in the pathogen population at very low frequency, maintained through balancing selection, and increased rapidly in response to selection from repeated exposure to host resistance.
Characterization of Salmonella Dublin isolated from bovine and human hosts
Authors: Paudyal Narayan , Pan Hang , Elbediwi Mohammed , Zhou Xiao , Peng Xianqi , Li Xiaoliang , Fang Weihuan , Yue Min 
Published: October 2019

Abstract

Background
Salmonella enterica subsp. enterica serovar Dublin (S. Dublin), a cattle adapted serovar causes enteritis, and systemic disease in bovines. The invasive index of this serovar far exceeds that of the other serovars and human infections often present as fatal or highly resistant infections. In this, observational study, phenotypic properties of human and bovine-derived isolates of S. Dublin along with antibiogram of common antimicrobials were evaluated. The multiplex PCR confirmed isolates were genotyped using 7-gene legacy MLST. MIC assay was done by broth microdilution method. Previously published protocols were used to assess the motility, biofilm formation and morphotype. Vi antigen was agglutinated using commercial antiserum. Caenorhabditis elegans infection model was used to evaluate the virulence potiential. Phenotyping experiments were done in duplicates while virulence assay was done in triplicates. Whole-genome sequencing was used to predict the genes responsible for acquired resistance and a genotype-phenotype comparison was made.

Results
We evaluated 96 bovine and 10 human isolates in this study. All the isolates belonged to ST10 in eBG53 and were negative for Vi-antigen. The swarming motility, biofilm formation and morphotype were variable in the isolates of both groups. Resistance to sulfamethoxazole, ampicillin, chloramphenicol, tetracycline was > 90% in animal isolates whereas resistance to sulfamethoxazole was > 70% in human isolates. MDR was also higher in animal isolates. Human isolates were significantly (P < 0.0001) more virulent than animal isolates on C. elegans infection model. The genomic comparison based on the core SNPs showed a high degree of homogeneity between the isolates. The carriage of IncA/C2 plasmid was seen as a typical feature of isolates from the bovine hosts.

Conclusion
Human isolates showed more diversity in the phenotypic assays. Animal isolates showed a higher degree of antimicrobial resistance with greater MDR but human isolates formed more biofilm and had greater swarming motility as well as increased virulence to the nematode C. elegans. The carriage of IncA/C2 plasmid could contribute to the distinguishing feature of the bovine isolates. The tandem use of genotypic-phenotypic assays improves the understanding of diversity and differential behaviour of the same serovar from unrelated host sources.
Incorporating adjustments for variability in control group response rates in network meta-analysis: a case study of biologics for rheumatoid arthritis
Authors: Cameron Chris , Varu Abhishek , Lau Arthur , Gharaibeh Mahdi , Paulino Marcelo , Rogoza Raina 
Published: October 2019

Abstract

Background
The importance of adjusting for cross-study heterogeneity in control group response rates when conducting network meta-analyses (NMA) was demonstrated using a case study involving a comparison of biologics for the treatment of moderate-to-severe rheumatoid arthritis.

Methods
Bayesian NMAs were conducted for American College of Rheumatology (ACR) 50 treatment response based upon a set of randomized controlled trials (RCTs) identified by a recently completed systematic review of the literature. In addition to the performance of an unadjusted NMA, a model adjusting for cross-study heterogeneity of control group response rates using meta-regression was fit to the data. Model fit was evaluated, and findings from both analyses were compared with regard to clinical interpretations.

Results
ACR 50 response data from a total of 51 RCTs and 16,223 patients were analyzed. Inspection of cross-study variability in control group response rates identified considerable differences between studies. NMA incorporating adjustment for this variability was associated with an average change of 38.1% in the magnitude of the ORs between treatment comparisons, and over 64% of the odds ratio changed by 15% or more. Important changes in the clinical interpretations drawn from treatment comparisons were identified with this improved modeling approach.

Conclusions
In comparing biologics for moderate to severe rheumatoid arthritis, failure to adjust for cross-trial differences in the control arm response rates in NMA can lead to biased estimates of comparative efficacy between treatments.
A randomized controlled efficacy study of the Medido medication dispenser in Parkinson’s disease
Authors: Hannink K. , ter Brake L. , Oonk N.G.M. , Wertenbroek A.A. , Piek M. , Vree-Egberts L. , Faber M.J. , van der Palen J. , Dorresteijn L.D. 
Published: October 2019

Abstract

Background
Complex medication schedules in Parkinson’s disease (PD) result in lower therapy adherence, which contributes to suboptimal therapy and clinical deterioration. Medication reminder systems might improve therapy adherence and subsequently improve symptoms of PD. This randomized controlled study assessed the effect of the electronic medication dispenser Medido on physical disability in PD, as a proxy for changes in therapy adherence.x

Methods
Eighty-seven patients were randomized into the Medido group or control group. The primary outcome of physical disability was measured by the AMC Linear Disability Scale (ALDS). Secondary outcomes were quality of life (QoL) (PDQ-39), health status (EQ5D-5L, VAS), non-motor symptoms (NMS-Quest), and QoL of the caregiver (PDQ-carer). Measurements were performed at baseline, and after 3 and 6 months follow-up.

Results
When using the Medido, a non-significant improvement of 3.0 points (95% CI -5.6;11.6) was seen in ALDS. The exploratory subgroup Hoehn & Yahr classification (H&Y) > 2.5 improved significantly on ALDS with 14.7 points (95% CI -28.5;-0.9, p = 0.029 for group x time interaction). QoL deteriorated with 1.0 point in PDQ-39 (p = 0.01 for group x time interaction) in favor of the control group. Non-significant differences were observed for VAS (0.4 points, p = 0.057) and NMS-Quest (1.3 points, p = 0.095) in favor of the Medido group. No changes over time were observed in EQ5D-5L and PDQ-carer.

Conclusions
Based on these data, no firm conclusion can be drawn, but use of the Medido medication dispenser may result in a clinical improvement of physical disability and seems particularly appropriate for more severe patients.

Trial registration
NTR3917. Registered 19 March 2013.
Correction to: Detection of Mycobacterium tuberculosis in pediatric stool samples using TruTip technology
Authors: Mesman Annelies W. , Soto Martin , Coit Julia , Calderon Roger , Aliaga Juan , Pollock Nira R. , Mendoza Milagros , Mestanza Francisco M. , Mendoza Carlos J. , Murray Megan B. , Lecca Leonid , Holmberg Rebecca , Franke Molly F. 
Published: October 2019

Following publication of the original article [1]. The authors reported that there is a mistake in Fig. 1: the number of patients in the control group its 449 patients, instead of 455.
Cutaneous leishmaniasis a neglected tropical disease: community knowledge, attitude and practices in an endemic area, Northwest Ethiopia
Authors: Tamiru Helina Fikre , Mashalla Yohana James , Mohammed Rezika , Tshweneagae Gloria Thupayagale 
Published: October 2019

Abstract

Background
Cutaneous leishmaniasis is one of the neglected tropical diseases in the Ethiopian highlands and studies on assessment of knowledge, attitude and practice of the community in endemic areas are scanty. The study aimed to assess the knowledge, attitude towards cutaneous leishmaniasis and treatment seeking practices in people living in the endemic highlands areas in the Northwest, Ethiopia and to provide evidence-based information to guide development of appropriate interventions to reduce the impact of cutaneous leishmaniasis on communities.

Methods
Quantitative cross-sectional study was conducted in cutaneous leishmaniasis endemic districts (woredas) using a semi structured questionnaire. Households were randomly selected according to probability proportional to size of households in each enumeration area. Systematic random sampling of eligible households was based on the number of households recorded during listing of households. Descriptive statistics was used to describe numerical data, organise and summarise the data in a manner that gave meaning to the numerical form. Frequency tables were used to show descriptive analysis and regression analysis was used to determine correlation between variables.

Results
Majority of respondents 321(78.7%) lived in rural areas, age ranged between 18 and 85 years and most were farmers. Illiteracy was high (47.6%) among respondents and majority 358(87.8%) had seen patients with CL. Less than quarter (21.6%) had heard about sand flies and knowledge on the peak transmission period was low (46.3%). About 192 (47.1%) of the respondents indicated disfiguring lesions were the major clinical presentations, less than half 55(27.5%) of urban residents believed CL was treatable compared to 145(72.5%) of rural residents (P < 0.001). Traditional medicines were indicated as best treatment option by 209(51.2%) compared to 114(27.9%) for modern treatment. Major factors influencing treatment options included accessibility to treatment facilities, distance and short duration of treatment. Participants expressed negative experiential attitude and perceived control towards modern treatment because of inaccessibility and distance from where modern treatment is provided.

Conclusion
Priority should be given to primary prevention and appropriate awareness campaigns on lesion recognition. Information on modern treatment should be intensified.
Double- versus single-balloon catheters for labour induction and cervical ripening: a meta-analysis
Authors: Liu Xiyao , Wang Yu , Zhang Fan , Zhong Xiaoni , Ou Rong , Luo Xin , Qi Hongbo 
Published: October 2019

Abstract

Background
The induction of labour is an increasingly common procedure in the obstetrics field. Various methods have been used to induce labour, among which balloon catheters play an important role. Whether the specifically designed double-balloon catheter is better than the single-balloon device in terms of efficacy, efficiency, safety and patient satisfaction remains controversial. Identifying even small differences between these two devices could be useful to guide clinical practices, to further explore their mechanisms, and to promote a better understanding of the optimal methods for inducing labour.

Methods
Using the population, intervention, comparison, outcomes and study designs (PICOS) principle, we searched the PubMed, EMBASE, OVID, SCI, CENTRAL, ClinicalTrial.gov, and CDSR databases to identify relevant randomised controlled trials (RCTs) from inception through February 14, 2018. The primary outcome was the caesarean delivery rate, and the secondary outcomes focused on efficacy, efficiency, safety, and patient satisfaction. The relative risks or mean differences, including their 95% confidence intervals, were calculated using fixed-effects or random-effects models. All statistical analyses were completed with RevMan version 5.3.

Results
From a total of 1326 articles, 7 RCTs involving 1159 women were included. There were no significant differences in primary outcomes (RR, 0.88 [0.65, 1.2]; p-value, 0.43) or secondary outcomes identified between single- and double-balloon catheters. However, heterogeneity existed for some aspects.

Conclusion
Both kinds of balloon catheter have similar levels of efficacy, efficiency, safety and patient satisfaction; however, the single-balloon method is considered to be more cost-effective.