bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of climate change and land cover/use transition impacts on runoff variations in the upper Hailar Basin, NE China
Authors: Yan Yuhui , Xue Baolin , A Yinglan , Sun Wenchao , Zhang Hanwen 
Published: May 2020

AbstractQuantification of runoff change is vital for water resources management, especially in arid or semiarid areas. This study used the Soil and Water Assessment Tool (SWAT) distributed hydrological model to simulate runoff in the upper reaches of the Hailar Basin (NE China) and to analyze quantitatively the impacts of climate change and land-use change on runoff by setting different scenarios. Two periods, i.e., the reference period (before 1988) and the interference period (after 1988), were identified based on long-term runoff datasets. In comparison with the reference period, the contribution rates of both climate change and land-use change to runoff change in the Hailar Basin during the interference period were 83.58% and 16.42%, respectively. The simulation analysis of climate change scenarios with differential precipitation and temperature changes suggested that runoff changes are correlated positively with precipitation change and that the impact of precipitation change on runoff is stronger than that of temperature. Under different economic development scenarios adopted, land use was predicted to have a considerable impact on runoff. The expansion of forests within the basin might induce decreased runoff owing to enhanced evapotranspiration.
Experimental evidence dynamic pressures reduction on plunge pool floors downstream flip bucket for increasing downstream face slopes
Authors: Moghadam Mehdi Karami , Amini Ata , Hosseini Hasan 
Published: May 2020

Abstract
In this research, the ejecting jet from a flip bucket downstream of a chute spillway was simulated using physical modeling. The effects of influencing parameters upon fluctuations and extreme values of dynamic pressure were investigated. The angles of 0°, 30°, 45°, and 60° were adopted for the mobile bottom wall. The discharges were set as 67, 86, 161, and 184 litre/s and the depths of water cushion on the mobile bottom wall were set as 0, 15, 30, and 45 cm. The method suggested by Castillo for computation of fluctuating coefficient of dynamic pressure (see Castillo (2007) Pressure characterization of undeveloped and developed jets in shallow and deep pool. Proceedings of the Congress-International Association for Hydraulic Research32 (2), 645) was validated via the laboratory data. The results showed that the increase in water cushion depth downstream has led to a decrease in mean pressure and in pressure fluctuations. The analyses showed that the fluctuating pressure coefficient was a function of water cushion depth, and its maximum value was taken when there was a water cushion on the mobile bottom wall. With an increase in discharge and mobile bottom wall angle, the maximum value of the fluctuating coefficient occurred in less water cushion depth. Moreover, with the growth of discharge, the maximum positive and negative fluctuations of the pressure increased first and then decreased.
Número especial do X Seminário Brasileiro sobre Pequenas Frutas
Authors: SIMÕES Fabiano , PAIM Leonardo Soldatelli , ROSSSI Andrea de 
Published: May 2020

A expressividade da produção de pequenas frutas é crescente nas últimas décadas no Brasil, uma vez considerada a demanda por elevada qualidade e funcionalidade dos alimentos. O Sul do país, sobretudo a região fisiográfica dos Campos de Cima da Serra no Rio Grande do Sul, apresenta grande potencial para o cultivo, ganhando destaque. O cultivo de morangueiros, amoreiras-pretas, mirtileiros e framboeseiras, dentre outros, apresenta dificuldades tecnológicas inerentes à produção, manejo fitotécnico e pós-colheita. Objetivando-se mitigar ou eliminar tais problemáticas, tendo em vista a defasagem de informações, a realização de encontros sobre pequenas frutas surge como grande oportunidade para promover discussões acerca das tecnologias adotadas e, acima de tudo, novas alternativas para serem implementadas por produtores brasileiros.
O Seminário Brasileiro sobre Pequenas Frutas foi criado em 2002 numa reunião de trabalho da equipe da Emater/RS-Ascar de Vacaria quando se pensou, na ocasião, em realizar um evento regional, que discutisse tecnologias de produção e políticas para o desenvolvimento e ampliação do cultivo de pequenas frutas, já que havia um número relevante de produtores familiares, no município, envolvidos na produção de amora-preta.
A Embrapa Uva e Vinho e a Embrapa Clima Temperado, junto à Prefeitura Municipal de Vacaria, já parceiras na introdução e fomento desses cultivos, prontamente incorporaram-se à ideia de realização do evento, cuja primeira edição, realizada em maio de 2002, foi intitulada 1º Seminário Regional sobre Pequenas Frutas. O evento recebeu abrangência nacional logo na 2ª edição, sendo renomeado para Seminário Brasileiro sobre Pequenas Frutas, pioneiro e principal encontro sobre pequenas frutas no Brasil. Assim, é considerado um marco no desenvolvimento do polo de produção de pequenas frutas, caracterizando-se pela grande participação de agricultores familiares.
A diversificação de cultivos e ampliação de áreas cultivadas nos Campos de Cima da Serra, bem como o surgimento de polos de produção de pequenas frutas em diversos estados brasileiros, tem exigido dinâmica inovadora da organização do evento para a idealização das edições. A partir de 2005, por exemplo, o Seminário Brasileiro sobre Pequenas Frutas passou a ter periodicidade bianual. No último evento, em julho de 2017, houve a participação de 250 pessoas. A realização da X edição, em julho de 2019, contou com palestrantes de renome nacional e três palestrantes internacionais (Itália). Nesta ocasião, assim como na anterior, os autores submeteram resumos expandidos, porém, uma vez considerada edição comemorativa, os oito melhores trabalhos apresentados no X Seminário Brasileiro sobre Pequenas Frutas foram selecionados para a publicação na edição especial da Revista Eletrônica Científica da UERGS.
False Laboratory Test Result Through Colistin Interference in an Intensive Care Patient: Case Report
Authors: Pehlivan Veli F. , Gönel Ataman , Pehlivan Basak , Koyuncu Ismail 
Published: May 2020

Background:
In blood samples taken for testing purposes during drug infusion in the
intensive care unit, there is a risk of interference due to drug-reactive interaction during the
analysis.

Case Report:
A 19-year-old female patient had undergone surgery for intracranial astrocytoma, 12
years ago. Acinetobacter baumannii was found in the blood culture and deep tracheal aspiration
fluid of the patient who had a fever (39.2 °C) with a body temperature during the follow-up. The
patient was started on colistin 2 * 4.5 million IU. After the colistin infusion, biochemical tests were
requested to control the patient’s clinical situation. CK-MB mass and ProBNP values were
measured in high concentrations. Cardiology consultation was requested to evaluate the increase
in the CK-MB mass and ProBNP values. The patient's ECG and echocardiography showed no
abnormality. The increase in cardiac markers was neither clinically acceptable nor insignificant.
There was no hemolysis in the sample or analytical error in the device. Variability in the tests was
thought to be due to the interference. As the bloodletting time was questioned, it was determined
that it was taken during colistin treatment. In order to determine the effect of colistin-related
interference on the other tests, the laboratory was contacted and additional tests (TSH, FT4, Anti-
TPO, B-HCG, Estradiol, Prolactin, CA 125, CA 15-3, CA 19-9, Vitamin B12, C-Peptide, DDimer,
PTH, 25 hydroxy vitamin D, PT, INR, APTT) were conducted. During colistin treatment,
in many tests, bias was detected between -75 and + 268.80%.

Conclusion:
Clinicians should consider suspicious test results that are incompatible with the
diagnosis for the possibility of erroneous measurements due to colistin interference and review the
sampling processes.
Pharmacogenetic Evaluation of Metformin and Sulphonylurea Response in Mexican Mestizos with Type 2 Diabetes
Authors: Marta Menjivar , Sánchez-Pozos Katy , Jaimes-Santoyo Joel , Monroy-Escutia Jazmin , Rivera- Santiago Carolina , de los Ángeles Granados-Silvestre María , Ortiz-López María Guadalupe 
Published: May 2020

Background:In Mexico, approximately 25% of patients with type 2 diabetes (T2D) have adequate glycemic control. Polymorphisms in pharmacogenetic genes have been shown to have clinical consequences resulting in drug toxicity or therapeutic inefficacy.Objective:The study aimed to evaluate the impact of variants in genes known to be involved in response to oral hypoglycemic drugs, such as CYP2C9, OCT, MATE, ABCA1 and C11orf65, in the Mexican Mestizo population of T2D patients.Methods:In this study, 265 patients with T2D were enrolled from the Hospital Juárez de México, Mexico City. Genotyping was performed by TaqMan® assays. SNP-SNP interactions were analyzed using the multifactor dimensionality reduction (MDR) method.Results:Carriers of the del allele of rs72552763 could achieve better glycemic control than noncarriers. There was a significant difference in plasma glucose and HbA1c levels among rs622342 genotypes. The results suggested an SNP-SNP interaction between rs72552763 and rs622342 OCT1 and rs12943590 MATE2.Conclusion:The interaction between rs72552763 and rs622342 in OCT1, and rs12943590 in MATE2 suggested an important role of these polymorphisms in metformin response in T2D Mexican Mestizo population.
Absorption, Metabolism and Excretion of Surufatinib in Rats and Humans
Authors: Li Ke , Ma Sheng , Miao Liyan , Fan Songhua , Pan Bin , Zhang Weihan , Su Weiguo , Xiong Yating , Gu Zheming , Guo Lian , Sai Yang 
Published: May 2020

Background:
Surufatinib is a potent small-molecule tyrosine kinase inhibitor and exhibited significant
efficacy in the treatment of neuroendocrine tumors in clinical trials.

Objective:
The absorption, metabolism and excretion of surufatinib were investigated in rats and human volunteers
following a single oral dose of [14C] surufatinib.

Methods:
The radioactivity was measured in plasma, urine, feces and bile by liquid scintillation counting, and the
metabolites were characterized by liquid chromatography coupled to mass spectrometry.

Results:
Surufatinib was orally absorbed similarly in rats and human volunteers, with the median Tmax of 4 hours
post-dose. The estimated t1/2 appeared longer in humans than in rats (mean t1/2: 3.12 hour for male rats, 6.48 hours for
female rats and 23.3 hours for male human volunteers). The excretion of surufatinib was almost complete in rats and
human volunteers in the studies, with the total radioactivity recovery of >90% of the dose. Similarly, in rats and
humans, fecal excretion predominated (approximately 87% of the dose recovered in feces and only 5% in urine). The
parent drug was the major radioactive component detected in the plasma extracts of rats and humans, and no single
circulating metabolite accounted for >10% of the total radioactivity. Unchanged drug was a minor radioactive
component in the excreta of rats and humans.

Conclusion:
Fecal excretion was the predominant way for the elimination of surufatinib and its metabolites in rats
and humans. No disproportionate circulating metabolite was observed in humans.
Heat Stress and Pulsed Unfocused Ultrasound: The Viability of these Physical Approaches for Drug Delivery into Testicular Seminiferous Tubules
Authors: Li Yuanyuan , Zafar Mohammad Ishraq , Wang Xiaotong , Ding Xiaofang , Li Honggang 
Published: May 2020

Aim:
To investigate the application of Scrotal Heat Stress (SHS) and Pulsed Unfocused Ultrasound
(PuFUS) to explore Blood-Testis Barrier (BTB) permeability in adult mice.

Background:
The BTB provides a stable microenvironment and a unique immune barrier for spermatogenesis.
Meanwhile, it blocks macromolecular substances access, including therapeutic agents and antibodies,
thereby it decreases the therapeutic or immunocontraception effects.

Objectives:
To determine the viability of these physical approaches in delivering macromolecular substances
into seminiferous tubules.

Material & Methods:
Mice were subjected to receive single SHS intervention at 39°C, 41°C, or 43°C
for 30 min. Whereas, mice received the PuFUS intervention at 1.75w/cm2, 1.25w/cm2, and 2.5w/cm2 for
2 min, 5 min, and 10 min, respectively. The Biotin and macromolecular substances (IgG, IgM, and
exosomes) were separately injected into the testicular interstitium at different times following SHS or
PuFUS interventions, to observe their penetration through BTB into seminiferous tubules.

Results:
As detected by Biotin tracer, the BTB opening started from day-2 following the SHS and lasted
for more than three days, whereas the BTB opening started from 1.5h following PuFUS and lasted up to
24h. Apparent penetration of IgG, IgM, and exosomes into seminiferous tubules was observed after five
days of the SHS at 43°C, but none at 39°C, or any conditions tested with PuFUS.

Conclusion:
The current results indicate that SHS at 43°C comparatively has the potential for delivering
macromolecular substances into seminiferous tubules, whereas the PuFUS could be a novel, quick, and
mild approach to open the BTB. These strategies might be useful for targeted drug delivery into testicular
seminiferous tubules. However, further studies are warranted to validate our findings.
Association Between Coagulation Function and Spontaneous Hemorrhagic Transformation in Acute Ischemic Stroke
Authors: Ye Chen , Wang Yanan , Song Quhong , Liu Junfeng , Wei Chenchen , Liu Ming 
Published: May 2020

Background and Purpose:
Hemorrhagic transformation (HT) has an adverse effect on
the prognosis of patients with acute ischemic stroke, and it is currently known associated with coagulation
system. But the conclusion is not consistent and remains to be identified. The aim of this
study was to investigate the association between coagulation function and spontaneous hemorrhagic
transformation.

Methods:
Patients within 7 days from the onset of ischemic stroke who did not receive reperfusion
therapy (thrombolysis or endovascular treatment) were included between January 2016 and October
2017. Coagulation function indicators, including prothrombin time (PT), activated partial
thromboplastin time (APTT), international normalized ratio (INR), thrombin time (TT) and fibrinogen
(FIB), were tested within 24 h after admission. HT was defined as hemorrhage presented on
follow-up magnetic resonance imaging (MRI) or computed tomography (CT) but not on baseline
CT. We performed binary logistic regression to examine the association between coagulation function
and HT. The coagulation indicators were entered into logistic regression analysis as continuous
variables (per 1-unit/L increase) and four-categorized variables (with data collapsed into quartiles),
respectively.

Results:
A total of 1141 patients were included (mean age, 64 ± 15 years; 63.7% males). 102 patients
experienced HT (8.9%), of whom 14 patients experienced symptomatic HT (sHT, 1.2%).
After adjustment for confounders, TT in the highest quartile is inversely associated with risk of HT
(as continuous variable, odds ratio [OR] 0.85; 95% confidence level [CI] 0.73-0.99, P = 0.042; as
four-categorized variable, OR 0.36, 95% CI 0.18 - 0.7, P = 0.003). Whether as continuous variables
or four-categorized variables, PT, INR, APTT and FIB had no association with HT.

Conclusion:
: Not the whole process of coagulation function is associated with spontaneous HT.
Prolonged TT, which may indicate an extension of the last step of the coagulation process, is independently
and inversely associated with spontaneous HT in patients with acute ischemic stroke.
Molecular Insights into the Interaction of Ursolic Acid and Cucurbitacin from Colocynth with Therapeutic Targets of Mycobacterium tuberculosis
Authors: Ali Mohammad Ajmal , Farah Mohammad Abul , Lee Joongku , Al-Anazi Khalid M. , Al-Hemaid Fahad M.A. 
Published: May 2020

Aims:Medicinal plants like Citrullus colocynthis are a potential choice to produce helpful novel antimycobacterial drugs. The existence of a range of natural products in the plants, especially Ursolic Acid (UA) and cucurbitacin E 2-0-β-d-glucopyranoside (CEG), with promising antibacterial activity against a variety of bacteria, prompted the need to check its actions against Mycobacterium tuberculosis (Mtb).Background:Mycobacterium tuberculosis (Mtb), an obligate human pathogen causes tuberculosis and is one of the major causes of death worldwide. A few combinations of drugs are currently accessible for treating TB patients, but these are inadequate to tackle worldwide TB cases.Objective:The molecular interactions between ursolic acid and cucurbitacin E with the eight potential Mtb target proteins were investigated with the objective of finding drug-like inhibitors.Methods:Avogadro v.1.2.0 and Openbabel v.2.4.1 were used for creating file formats required for docking analysis. Molecular docking was performed with eight different proteins essential for Mtb metabolism and survival. AutoDock v.4.2 and AutoDock vina v.1.1.2 were used for docking and Gromacs 5.1.4 was used for simulation studies.Results and Discussion:Among the two ligands used in this research, cucurbitacin E showed a better docking score relative to the drugs presently available for all the target proteins. Rifampicin showed the best binding affinity (among known inhibitors) i.e. -10.8 kcal/mol with C terminal caspase recruitment domain. Moreover, ursolic acid and cucurbitacin E showed uniform binding score (above -7.5 kcal/mol) with all the target proteins, acknowledged its availability as a potential multi-target drug.Conclusion:Ursolic acid can be useful in the creation of novel, multi-targeted and effective anti- TB medicines since it showed stable structure with FabH.
Recruiting Student Health Coaches to Improve Digital Blood Pressure Management: Randomized Controlled Pilot Study
Authors: Vasti Elena , Pletcher Mark J 
Published: May 2020

Background
Hypertension is a significant problem in the United States, affecting 1 in 3 adults aged above 18 years and is associated with a higher risk for cardiovascular disease and stroke. The prevalence of hypertension has increased in medically underserved areas (MUAs). Mobile health technologies, such as digital self-monitoring devices, have been shown to improve the management of chronic health conditions. However, patients from MUAs have reduced access to these devices because of limited resources and low health literacy. Health coaches and peer training programs are a potentially cost-effective solution for the shortage of physicians available to manage hypertension in MUAs. Activating young people as student health coaches (SHCs) is a promising strategy to improve community health.

Objective
This pilot study aims to assess (1) the feasibility of training high school students as health technology coaches in MUAs and (2) whether the addition of SHCs to digital home monitoring improves the frequency of self-monitoring and overall blood pressure (BP) control.

Methods
In total, 15 high school students completed 3-day health coach training. Patients who had a documented diagnosis of hypertension were randomly assigned to 1 of the 3 intervention arms. The QardioArm alone (Q) group was provided a QardioArm cuff only for convenience. The SHC alone (S) group was instructed to meet with a health coach for 30 min once a week for 5 weeks to create action plans for reducing BP. The student+QardioArm (S+Q) group received both interventions.

Results
Participants (n=27) were randomly assigned to 3 groups in a ratio of 9:9:9. All 15 students completed training, of which 40% (6/15) of students completed all the 5 meetings with their assigned patient. Barriers to feasibility included transportation and patient response drop-off at the end of the study. Overall, 92% (11/12) of the students rated their experience as very good or higher and 69% (9/13) reported that this experience made them more likely to go into the medical field. There was a statistically significant difference in the frequency of cuff use (S+Q vs Q groups: 37 vs 17; P<.001). Participants in the S+Q group reported better BP control after the intervention compared with the other groups. The average BP at the end of the intervention was 145/84 (SD 9/18) mm Hg, 150/85 (SD 18/12) mm Hg, and 128/69 (SD 20/14) mm Hg in the Q, S, and S+Q groups, respectively.

Conclusions
This pilot study demonstrates the feasibility of pairing technology with young student coaches, although challenges existed. The S+Q group used their cuff more than the Q group. Patients were more engaged in the S+Q group, reporting higher satisfaction with their SHC and better control of their BP.
Considerations for Health Researchers Using Social Media for Knowledge Translation: Multiple Case Study
Authors: Elliott Sarah A , Dyson Michele P , Wilkes Gilbert V , Zimmermann Gabrielle L , Chambers Christine T , Wittmeier Kristy DM , Russell Dianne J , Scott Shannon D , Thomson Denise , Hartling Lisa 
Published: May 2020

Background
Despite extensive literature describing the use of social media in health research, a gap exists around best practices in establishing, implementing, and evaluating an effective social media knowledge translation (KT) and exchange strategies.

Objective
This study aims to examine successes, challenges, and lessons learned from using social media within health research and to create practical considerations to guide other researchers.

Methods
The Knowledge Translation Platform of the Alberta Strategy for Patient-Oriented Research SUPPORT Unit formed a national working group involving platform staff, academics, and a parent representative with experience using social media for health research. We collected and analyzed 4 case studies that used a variety of social media platforms and evaluation methods. The case studies covered a spectrum of initiatives from participant recruitment and data collection to dissemination, engagement, and evaluation. Methods and findings from each case study as well as barriers and facilitators encountered were summarized. Through iterative discussions, we converged on recommendations and considerations for health researchers planning to use social media for KT.

Results
We provide recommendations for elements to consider when developing a social media KT strategy: (1) set a clear goal and identify a theory, framework, or model that aligns with the project goals and objectives; (2) understand the intended audience (use social network mapping to learn what platforms and social influences are available); (3) choose a platform or platforms that meet the needs of the intended audience and align well with the research team’s capabilities (can you tap into an existing network, and what mode of communication does it support?); (4) tailor messages to meet user needs and platform requirements (eg, plain language and word restrictions); (5) consider timing, frequency, and duration of messaging as well as the nature of interactions (ie, social filtering and negotiated awareness); (6) ensure adequate resources and personnel are available (eg, content creators, project coordinators, communications experts, and audience stakeholder or patient advocate); (7) develop an evaluation plan a priori driven by goals and types of data available (ie, quantitative and qualitative); and (8) consider ethical approvals needed (driven by evaluation and type of data collection).

Conclusions
In the absence of a comprehensive framework to guide health researchers using social media for KT, we provide several key considerations. Future research will help validate the proposed components and create a body of evidence around best practices for using and evaluating social media as part of a KT strategy