bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muck, Mummies and Medicine: Disgust in Early Modern Science
Authors: Schober Sarah-Maria 
Published: September 2020

Abstract
This essay shows that early modern practices that used human bodily matter cannot be – as hitherto – explained by the absence of the emotion of disgust nor as being conducted in spite of disgust. Instead, it proposes to read those practices’ changing history as part of the history of the ‘paradox of disgust’. Four case studies (on anatomy, excrement, mummies and skulls) demonstrate that disgust was highly productive: it attracted fascination, allowed physicians to fashion themselves, and was even believed capable of healing. Over time and for complex reasons, however, the productive side of disgust declined. Combining current approaches in the history of emotions and material culture studies, this essay sets out not only to propose a new narrative for the changing role of disgust in early modern science and societies, but also to explore how variations in settings and human intervention changed the way emotions were used and perceived.
Comparison of Local, Regional, and Scaling Models for Rainfall Intensity–Duration–Frequency Analysis
Authors: Mascaro Giuseppe 
Published: September 2020

AbstractIntensity–duration–frequency (IDF) analyses of rainfall extremes provide critical information to mitigate, manage, and adapt to urban flooding. The accuracy and uncertainty of IDF analyses depend on the availability of historical rainfall records, which are more accessible at daily resolution and, quite often, are very sparse in developing countries. In this work, we quantify performances of different IDF models as a function of the number of available high-resolution (Nτ) and daily (N24h) rain gauges. For this aim, we apply a cross-validation framework that is based on Monte Carlo bootstrapping experiments on records of 223 high-resolution gauges in central Arizona. We test five IDF models based on (two) local, (one) regional, and (two) scaling frequency analyses of annual rainfall maxima from 30-min to 24-h durations with the generalized extreme value (GEV) distribution. All models exhibit similar performances in simulating observed quantiles associated with return periods up to 30 years. When Nτ > 10, local and regional models have the best accuracy; bias correcting the GEV shape parameter for record length is recommended to estimate quantiles for large return periods. The uncertainty of all models, evaluated via Monte Carlo experiments, is very large when Nτ ≤ 5; however, if N24h ≥ 10 additional daily gauges are available, the uncertainty is greatly reduced and accuracy is increased by applying simple scaling models, which infer estimates on subdaily rainfall statistics from information at daily scale. For all models, performances depend on the ability to capture the elevation control on their parameters. Although our work is site specific, its results provide insights to conduct future IDF analyses, especially in regions with sparse data.
Mountain Waves Produced by a Stratified Shear Flow with a Boundary Layer. Part II: Form Drag, Wave Drag, and Transition from Downstream Sheltering to Upstream Blocking
Authors: Lott François , Deremble Bruno , Soufflet Clément 
Published: September 2020

AbstractThe nonhydrostatic version of the mountain flow theory presented in Part I is detailed. In the near-neutral case, the surface pressure decreases when the flow crosses the mountain to balance an increase in surface friction along the ground. This produces a form drag that can be predicted qualitatively. When stratification increases, internal waves start to control the dynamics and the drag is due to upward-propagating mountain waves as in Part I. The reflected waves nevertheless add complexity to the transition. First, when stability increases, upward-propagating waves and reflected waves interact destructively and low-drag states occur. When stability increases further, the interaction becomes constructive and high-drag states are reached. In very stable cases, the reflected waves do not affect the drag much. Although the drag gives a reasonable estimate of the Reynolds stress, its sign and vertical profile are profoundly affected by stability. In the near-neutral case, the Reynolds stress in the flow is positive, with a maximum around the top of the inner layer, decelerating the large-scale flow in the inner layer and accelerating it above. In the more stable cases, on the contrary, the large-scale flow above the inner layer is decelerated as expected for dissipated mountain waves. The structure of the flow around the mountain is also strongly affected by stability: it is characterized by nonseparated sheltering in the near-neutral cases, by upstream blocking in the very stable case, and at intermediate stability by the presence of a strong but isolated wave crest immediately downstream of the ridge.
Enhancing the Electrochemical Properties of LaCoO3 by Sr-Doping, rGO-Compounding with Rational Design for Energy Storage Device
Authors: Zhang Bin , Yu Chuanfu , Li Zijiong 
Published: September 2020

AbstractPerovskite oxides, as a kind of functional materials, have been widely studied in recent years due to its unique physical, chemical, and electrical properties. Here, we successfully prepared perovskite-type LaCoO3 (LCOs) nanomaterials via an improved sol-gel method followed by calcination, and investigated the influence of calcination temperature and time on the morphology, structure, and electrochemical properties of LaCoO3 nanomaterials. Then, based on the optimal electrochemical performance of LCO-700-4 electrode sample, the newly synthesized nanocomposites of Sr-doping (LSCO-0.2) and rGO-compounding (rGO@LCO) through rational design exhibited a 1.45-fold and 2.03-fold enhancement in its specific capacitance (specific capacity). The rGO@LCO electrode with better electrochemical performances was further explored by assembling rGO@LCO//rGO asymmetric supercapacitor system (ASS) with aqueous electrolyte. The result showed that the ASS delivers a high energy density of 17.62 W h kg−1 and an excellent cyclic stability with 94.48% of initial capacitance after 10,000 cycles, which are good electrochemical performances among aqueous electrolytes for green and new efficient energy storage devices.
Broken basket conundrum
Authors: Sockkalingam Vigneswara Srinivasan Venkatachalap , Palathullil Datson George , Radhakrishnan Vijay , Palathullil George Abraham 
Published: September 2020

AbstractBackgroundBroken basket during retrograde intrarenal surgery (RIRS) is a known complication. The literature regarding this common complication is limited. We report a case of broken basket and explain the technique by which we retrieved the broken basket fragment that was entrapped around the calculus. We also analyze at the prevention strategies and better management strategies.Case presentationA 62-year-old male underwent RIRS for a 2-cm right renal lower calyceal calculus. A tipless nitinol stone basket got broken and distal part got entrapped around the calculus when basketing was attempted. We proceeded with stone fragmentation by RIRS. After complete stone fragmentation, another tipless nitinol stone basket was used to grab the broken tip of distal basket fragment which was lying in the renal pelvis. The broken basket fragment could be retrieved out in toto.ConclusionsBasketing large lower calyceal calculus should be attempted with caution. Partial or complete fragmentation of large calculus is preferable before basketing attempt. If the calculus is entrapped rather than forceful pulling, cutting the basket proximally near to the handle, followed by stone fragmentation, could minimize complications. Locating the broken tip of the basket fragment and grasping it makes the retrieval easier and safer.
Assessment of infection in newly diagnosed multiple myeloma patients: risk factors and main characteristics
Authors: Lin Chenyao , Shen Hui , Zhou Shuimei , Liu Minghui , Xu Anjie , Huang Shuang , Shen Changxin , Zhou Fuling 
Published: September 2020

Abstract
Background
Infection is a leading cause of morbidity and death in patients with multiple myeloma (MM). The increased susceptibility to infection is complicated and multifactorial. However, no studies have explored the spectrum and risk factors of infections in newly diagnosed MM patients at the first admission. This cross-sectional study aimed to provide ideas for the assessment, prevention and treatment of infection in newly diagnosed MM patients when admitted for the first time.

Methods
Retrospectively, the data from electronic medical records for 161 patients newly diagnosed with MM from May 2013 to December 2018 were analysed. All the information was collected at the time of admission, and the patients had received no antineoplastic therapy previously. Independent risk factors of infection in multiple myeloma were determined by univariate and multivariate analysis.

Results
Newly diagnosed patients with MM were highly susceptible to viruses (43.9%), especially Epstein-Barr virus (EBV) (24.4%) and hepatitis B virus (HBV) (17.1%). Advanced stage (ISS stage III, P = 0.040), more severe anaemia (Hb < 90 g/L, P = 0.044) and elevated CRP (> 10 mg/L, P = 0.006) were independent risk factors for infection. Moreover, infections represented a major survival threat to patients with newly diagnosed MM (P = 0.033), and the existence of risk factors for infection was significantly correlated with poor prognosis (P = 0.011), especially ISS stage III (P = 0.008) and lower haemoglobin level (P = 0.039).

Conclusions
Newly diagnosed MM patients are highly susceptible to viruses. Advanced ISS stage, more severe anaemia and the elevation of CRP are independent risk factors of infection, which also have a strong impact on prognosis. Our results suggest that viral infection should be taken into account if antibacterial drugs are not effective, and the prevention of infection and improvement of prognosis should be paid more attention in newly diagnosed patents with advanced stage and more severe anaemia.
Fetal sex and maternal insulin resistance during mid-pregnancy: a retrospective cohort study
Authors: Yamashita Hiroshi , Yasuhi Ichiro , Koga Megumi , Sugimi So , Umezaki Yasushi , Fukuoka Misao , Suga Sachie , Fukuda Masashi , Kusuda Nobuko 
Published: September 2020

Abstract
Background
Recent studies have suggested that fetal sex influences maternal glucose and insulin metabolism during pregnancy. We examined whether fetal sex is associated with maternal insulin resistance and the β-cell function during mid-pregnancy.

Methods
This retrospective study included singleton pregnant women who underwent a 75-g oral glucose tolerance test (OGTT) at 24–34 weeks of gestation due to positive diabetic screening. In addition to plasma glucose (PG), we measured plasma insulin during the OGTT to obtain surrogate indices associated with insulin resistance (IR), including homeostasis assessment model (HOMA) -IR and insulin sensitivity index (IsOGTT), and β-cell function, including insulinogenic index (II), HOMA-β, and area under the curve of insulin response. We compared these indices between women carrying male fetuses to those carrying female fetuses.

Results
The study population included 617 women (mean age, 32.4 ± 4.9 years) with a mean pre-pregnancy body mass index (BMI) of 22.6±4.5. They underwent the 75g-OGTT at 29.0 ± 2.5 weeks. Two hundred fifty-eight (42%) women were diagnosed with gestational diabetes (GDM). There was no significant difference in maternal age, pre-pregnancy BMI, gestational age at OGTT, PG at OGTT, or the prevalence of GDM between women with a male fetus (n=338) (male group) and those with a female fetus (n=279) (female group). Regarding the indices of IR, IR was significantly higher and insulin sensitivity was lower in the female group than in the male group (HOMA-IR: 7.0 [5-9.6] vs. 6.2 [4.6-8.8], p< 0.05; IsOGTT: 5.86 [4.29-7.83] vs. 6.29 [4.59-8.84], p< 0.01) (median [quartile range]). These differences remained significant after adjustment for maternal age, pre-pregnancy BMI, gestational age and fasting PG at OGTT, and the diagnosis of GDM. In contrast, the β-cell function did not differ between the two groups.

Conclusion
Maternal IR during mid-pregnancy was significantly higher in women carrying a female fetus than in those with a male fetus. The sex of the fetus may affect maternal insulin sensitivity during mid-pregnancy.
Upregulation of long non-coding RNA LOC284454 may serve as a new serum diagnostic biomarker for head and neck cancers
Authors: Fan Chunmei , Wang Jinpeng , Tang Yanyan , Zhang Shanshan , Xiong Fang , Guo Can , Zhou Yanhong , Li Zheng , Li Xiaoling , Li Yong , Li Guiyuan , Zeng Zhaoyang , Xiong Wei 
Published: September 2020

Abstract
Background
Identification of effective diagnostic and prognostic biomarkers of cancer is necessary for improving precision medicine. Long non-coding RNAs (lncRNAs) play an important regulatory role in tumor initiation and progression. The lncRNA LOC284454 is distinctly expressed in various head and neck cancers (HNCs), as demonstrated by our previous bioinformatics analysis. However, the expression levels and functions of LOC284454 in cancer are still unclear.

Methods
We investigated the dysregulation of lncRNAs in HNCs using the GEO database and found that LOC284454 was highly expressed in HNCs. Serum samples from 212 patients with HNCs and 121 normal controls were included in this biomarker study. We measured the expression of LOC284454 in the sera of HNC patients and normal controls using RT-qPCR. Receiver operating characteristics (ROC) analysis is an important statistical method that is widely used in clinical diagnosis and disease screening. ROC was used to analyze the clinical value of LOC284454 in the early diagnosis of HNCs.

Results
LOC284454 was significantly upregulated in the sera of patients with nasopharyngeal carcinoma, oral cancer, and thyroid cancer. LOC284454 upregulation had good clinical diagnostic value in these cancers, as evaluated by area under the ROC curve values of 0.931, 0.698, and 0.834, respectively.

Conclusions
LOC284454 may be a valuable serum biomarker for HNCs facilitating the early diagnosis of malignant cancers. Further studies are needed to elucidate the mechanisms underlying the involvement of LOC284454 in HNCs. This study provides the first evidence that LOC284454 may be a serum biomarker for HNCs.
Major depressive disorder and its association with adherence to antiretroviral therapy and quality of life: cross-sectional survey of people living with HIV/AIDS in Northwest Ethiopia
Authors: Asrat Biksegn , Lund Crick , Ambaw Fentie , Garman Emily Claire , Schneider Marguerite 
Published: September 2020

Abstract
Background
Major depression is believed to affect treatment adherence and overall quality of life (QoL) of people living with HIV/AIDS (PLWHA). Comorbid major depression contributes to a two-fold higher risk of mortality among PLWHA. Understanding the relationships of major depression, adherence to antiretroviral therapy (ART) and QoL is important to identify areas for intervention. The aim of this study is to examine relationship of major depressive disorder (MDD) and adherence to ART with QoL, and to investigate socio-demographic and clinical factors associated with MDD, adherence and QoL among PLWHA in Northwest Ethiopia.

Method
A cross-sectional study was conducted in the ART clinic of Felege-Hiwot referral hospital in Northwest Ethiopia from July to October 2019. Adult PLWHA were selected using a systematic random sampling technique. Data were collected using interview administered questionnaires and chart reviews. Mini International Neuropsychiatric Interview and WHOQOL-HIV-BREF-Eth instruments were used to measure MDD and QoL respectively. Adherence to ART was assessed using pill count data from patients’ adherence monitoring chart. Univariate and multivariate Poisson regressions were used to assess associations of socio-demographic and clinical factors with MDD and adherence to ART. A multivariate linear regression was used to examine the associations of both MDD and adherence with overall QoL.

Result
Of the total of 393 invited participants, 391 (99.5%) completed the interviews. MDD was negatively associated with overall QoL: participants with MDD had a lower QoL score of 0.17 points compared to those with no MDD. MDD was associated with reduced adherence to ART when functional disability was controlled (RR = 1.43; 95%CI = 1.05, 1.96; p = 0.025). However, there was no statistical association between adherence to ART and overall QoL. Functional disability was associated with both MDD (RR = 5.07; 95%CI = 3.27,7.86; p < 0.001) and overall QoL (β = 0.29; 95%CI = 0.21,0.36; p < 0.001).

Conclusion
The relationship between MDD and QoL indicates the need for feasible, acceptable and evidence-based mental health interventions to reduce depression and improve overall QoL of PLWHA. We recommend future studies investigate causal relationships of MDD, adherence to ART and QoL of PLWHA to better understand priority areas for intervention.
Identification of plasma lipid species as promising diagnostic markers for prostate cancer
Authors: Chen Xiaoli , Zhu Yong , Jijiwa Mayumi , Nasu Masaki , Ai Junmei , Dai Shengming , Jiang Bin , Zhang Jicai , Huang Gang , Deng Youping 
Published: September 2020

Abstract
Background
Prostate cancer is a very common and highly fatal in men. Current non-invasive detection methods like serum biomarker are unsatisfactory. Biomarkers with high accuracy for diagnostic of prostate cancer are urgently needed. Many lipid species have been found related to various cancers. The purpose of our study is to explore the diagnostic value of lipids for prostate cancer.

Results
Using triple quadruple liquid chromatography electrospray ionization tandem mass spectrometry, we performed lipidomics profiling of 367 lipids on a total 114 plasma samples from 30 patients with prostate cancer, 38 patients with benign prostatic hyperplasia (BPH), and 46 male healthy controls to evaluate the lipids as potential biomarkers in the diagnosis of prostate cancer. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database was used to construct the potential mechanism pathway. After statistical analysis, five lipids were identified as a panel of potential biomarkers for the detection of prostate cancer between prostate cancer group and the BPH group; the sensitivity, specificity, and area under curve (AUC) of the combination of these five lipids were 73.3, 81.6%, and 0.800, respectively. We also identified another panel of five lipids in distinguishing between prostate cancer group and the control group with predictive values of sensitivity at 76.7%, specificity at 80.4%, and AUC at 0.836, respectively. The glycerophospholipid metabolism pathway of the selected lipids was considered as the target pathway.

Conclusions
Our study indicated that the identified plasma lipid biomarkers have potential in the diagnosis of prostate cancer.
Selective digestive decontamination solution used as “lock therapy” prevents and eradicates bacterial biofilm in an in vitro bench-top model
Authors: Pérez-Granda María Jesús , Alonso Beatriz , Zavala Ricardo , Latorre María Consuelo , Hortal Javier , Samaniego Rafael , Bouza Emilio , Muñoz Patricia , Guembe María 
Published: September 2020

Abstract
Background
Most preventing measures for reducing ventilator-associated pneumonia (VAP) are based mainly on the decolonization of the internal surface of the endotracheal tubes (ETTs). However, it has been demonstrated that bacterial biofilm can also be formed on the external surface of ETTs. Our objective was to test in vitro the efficacy of selective digestive decontamination solution (SDDs) onto ETT to prevent biofilm formation and eradicate preformed biofilms of three different microorganisms of VAP.

Methods
We used an in vitro model in which we applied, at the subglottic space of ETT, biofilms of either P. aeruginosa ATCC 15442, or E. coli ATCC 25922, or S. aureus ATCC 29213, and the SDDs at the same time (prophylaxis) or after 72 h of biofilm forming (treatment). ETT were incubated during 5 days with a regimen of 2 h-locks. ETT fragments were analyzed by sonication and confocal laser scanning microscopy to calculate the percentage reduction of cfu and viable cells, respectively.

Results
Median (IQR) percentage reduction of live cells and cfu/ml counts after treatment were, respectively, 53.2% (39.4%—64.1%) and 100% (100%–100.0%) for P. aeruginosa, and 67.9% (46.7%–78.7%) and 100% (100%–100.0%) for E. coli. S. aureus presented a complete eradication by both methods. After prophylaxis, there were absence of live cells and cfu/ml counts for all microorganisms.

Conclusions
SDDs used as “lock therapy” in the subglottic space is a promising prophylactic approach that could be used in combination with the oro-digestive decontamination procedure in the prevention of VAP.
Diagnosis of Rare Diseases: a scoping review of clinical decision support systems
Authors: Schaaf Jannik , Sedlmayr Martin , Schaefer Johanna , Storf Holger 
Published: September 2020

AbstractBackgroundRare Diseases (RDs), which are defined as diseases affecting no more than 5 out of 10,000 people, are often severe, chronic and life-threatening. A main problem is the delay in diagnosing RDs. Clinical decision support systems (CDSSs) for RDs are software systems to support clinicians in the diagnosis of patients with RDs. Due to their clinical importance, we conducted a scoping review to determine which CDSSs are available to support the diagnosis of RDs patients, whether the CDSSs are available to be used by clinicians and which functionalities and data are used to provide decision support.MethodsWe searched PubMed for CDSSs in RDs published between December 16, 2008 and December 16, 2018. Only English articles, original peer reviewed journals and conference papers describing a clinical prototype or a routine use of CDSSs were included. For data charting, we used the data items “Objective and background of the publication/project”, “System or project name”, “Functionality”, “Type of clinical data”, “Rare Diseases covered”, “Development status”, “System availability”, “Data entry and integration”, “Last software update” and “Clinical usage”.ResultsThe search identified 636 articles. After title and abstracting screening, as well as assessing the eligibility criteria for full-text screening, 22 articles describing 19 different CDSSs were identified. Three types of CDSSs were classified: “Analysis or comparison of genetic and phenotypic data,” “machine learning” and “information retrieval”. Twelve of nineteen CDSSs use phenotypic and genetic data, followed by clinical data, literature databases and patient questionnaires. Fourteen of nineteen CDSSs are fully developed systems and therefore publicly available. Data can be entered or uploaded manually in six CDSSs, whereas for four CDSSs no information for data integration was available. Only seven CDSSs allow further ways of data integration. thirteen CDSS do not provide information about clinical usage.ConclusionsDifferent CDSS for various purposes are available, yet clinicians have to determine which is best for their patient. To allow a more precise usage, future research has to focus on CDSSs RDs data integration, clinical usage and updating clinical knowledge. It remains interesting which of the CDSSs will be used and maintained in the future.