bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aroma Profile of Two Populations of Salvia verbenaca Collected from Two Bio‐Geographical Zones from Jordan
Authors: Al‐Jaber Hala I. , Obeidat Safwan M. , Afifi Fatma U. , Abu Zarga Musa H. 
Published: December 2019

AbstractThe aroma emitted from the different organs of two Salvia verbenaca L. populations from Jordan were extracted by Solid Phase Micro‐Extraction (SPME) and then analyzed by GC/MS. The emission profile of the stem, leaf and sepal samples from the Mediterranean zone (Al‐Salt) was dominated by monoterpene hydrocarbons (68.0 %, 33.7 %, and 42.2 %, respectively). The emission profile of flowering parts including pre‐flowering buds, fully expanded flowers and petals was dominated by oxygenated monoterpenes (58.6 %, 59.3 % and 87.1 %, respectively). The major constituent detected in these organs was trans‐sabinene hydrate acetate (range 14.5 %–87.0 %). On the other hand, samples collected from Irano‐Turanian zone showed different emission patterns. While the stems, leaves and petal emissions were dominated by sesquiterpene hydrocarbons (54.9 %, 76.8 % and 52.6 %, respectively), monoterpene hydrocarbons dominated the emission profiles of the pre‐flowering buds (75.1 %) and fully expanded flowers (73.6 %). Petals emissions were characterized by high concentrations of oxygenated monoterpenes (58.8 %). Notably, trans‐sabinene hydrate dominated most organs emissions except for leaves (range 20.0 %–58.8 %). Principle Component Analysis (PCA) and Cluster Analysis (CA) revealed two different clusters related to the two different geographical zones. The current investigation revealed two ecotypes of S. verbenaca that could result in two different chemotypes. Trans‐sabinene hydrate acetate and trans‐sabinene hydrate are suggested compounds for identifying these two chemotypes.
Peptide Bond Cleavage by Ni(II) Ions within the Nuclear Localization Signal Sequence
Authors: Frączyk Tomasz , Bonna Arkadiusz , Stefaniak Ewelina , Wezynfeld Nina E. , Bal Wojciech 
Published: December 2019

AbstractNickel is harmful to humans, being both carcinogenic and allergenic. However, the mechanisms of this toxicity are still unresolved. We propose that Ni(II) ions disintegrate proteins by hydrolysis of peptide bonds preceding the Ser/Thr‐Xaa‐His sequences. Such sequences occur in nuclear localization signals (NLSs) of human phospholipid scramblase 1, Sam68‐like mammalian protein 2, and CLK3 kinase. We performed spectroscopic experiments showing that model nonapeptides derived from these NLSs bind Ni(II) at physiological pH. We also proved that these sequences are prone to Ni(II) hydrolysis. Thus, the aforementioned NLSs may be targets for nickel toxicity. This implies that Ni(II) ions disrupt the transport of some proteins from cytoplasm to cell nucleus.
Incidence, outcomes, and predictors of in‐hospital acute coronary syndrome following endovascular transcatheter aortic valve replacement in the United States
Authors: Nazir Salik , Ahuja Keerat R. , Donato Anthony , Grande Robert D. , Changal Khalid , Gad Mohamed M. , Saad Anas , Verma Beni R. , Syed Mubbasher A. , Sheikh Mujeeb , Kapadia Samir , Ramanathan P. Kasi 
Published: December 2019

AbstractBackgroundIncidence and outcomes of acute coronary syndrome (ACS) immediately following transcatheter aortic valve replacement (TAVR) remain largely unknown.ObjectivesThis study sought to assess the incidence, clinical characteristics, and outcomes of ACS following TAVR.MethodsWe queried the National Readmission Database from January 2012 to September 2015 for TAVR admissions with and without ACS, creating a propensity‐matched cohort to compare outcomes.ResultsA total of 48,454 patients underwent TAVR, with 1,332 (2.75%) developing ACS. TAVR patients with ACS compared to those without ACS had a significantly higher incidence of acute kidney injury (24.7 vs. 19.2%; p = .001), ischemic stroke (3.7 vs. 2.3%; p = .04), vascular complications (8.6 vs. 5.8%; p = .008), cardiogenic shock (9.8 vs. 1.9%; p < .001), cardiac arrest (5.1 vs. 2.8%; p = .002), mechanical circulatory support (8.1 vs. 1.5%; p < .001), and in‐hospital mortality (9.6 vs. 3.4%; p < .001). Additionally, TAVR with ACS had longer lengths of stay (median 10 days vs. 6 days; p < .001) and hospital charges (median $23,200 vs. $19,000; p < .001). Positive predictors of ACS were history of PCI (odds ratio, 1.43; 95% CI: 1.25–1.63), hyperlipidemia (odds ratio, 1.20; 95% CI: 1.07–1.34), chronic blood loss anemia (odds ratio, 2.16; 95% CI: 1.54–3.03), chronic kidney disease (odds ratio, 1.17; 95% CI: 1.04–1.31), fluid and electrolyte disorders (odds ratio, 1.65; 95% CI: 1.47–1.85), and weight loss (odds ratio, 1.53; 95% CI: 1.22–1.91). Heart failure (34%) was the most common reason for readmission in the ACS cohort.ConclusionACS after TAVR is uncommon but is associated with worse clinical outcomes and increased healthcare resource utilization.
The effect of stenting on blood pressure in hypertensive patients with symptomatic proximal subclavian or vertebral artery stenosis
Authors: Che Wuqiang , Dong Hui , Jiang Xiongjing , Xiong Hongliang , Chen Yang , Zou Yubao , Xu Bo , Gao Runlin 
Published: December 2019

AbstractObjectiveThis study aimed to evaluate the effect of stenting on blood pressure in hypertensive patients with symptomatic proximal subclavian or vertebral artery stenosis.BackgroundWhether posterior circulation revascularization could reduce blood pressure in hypertensive patients with posterior circulation hypoperfusion has not been investigated in humans.MethodsA total of 48 patients with essential hypertension (33 males; mean age 63.0 ± 8.7 years) with symptomatic proximal subclavian or vertebral artery stenosis who underwent stenting successfully at the Fuwai Hospital were prospectively enrolled between January 2014 and December 2015. All 48 patients were followed up at 1, 3, and 6 months after the procedure. Blood pressure, use of antihypertensive agents, and complications were investigated.ResultsBaseline values included office blood pressure of 132/77 ± 10/8 mmHg, mean 24‐hr blood pressure of 127/75 ± 12/9 mmHg, and mean antihypertensive agents used of 1.6 ± 0.8. Stenosis of the subclavian and vertebral arteries decreased from 88.9 ± 9.5% and 85.8 ± 7.4% to 5.5 ± 3.5% and 4.6 ± 3.7%, respectively, immediately after the procedure. Reductions in office blood pressure were − 7/−3 (SD 3/2), −9/−4 (5/3), and − 10/−5 (7/5) mmHg at 1, 3, and 6 months, respectively. While 24‐hr blood pressures after the procedure reduced by −5/−3 mmHg at 6 months, the total number of antihypertensive agents used at the aforementioned time points was unchanged.ConclusionThis first prospective cohort study in humans showed that posterior circulation stenting is apparently effective in reducing blood pressure in hypertensive patients with symptomatic proximal subclavian or vertebral artery stenosis.
Drug‐coated balloon after subintimal plaque modification in failed coronary chronic total occlusion percutaneous coronary intervention: A novel concept
Authors: Ybarra Luiz F. , Dandona Sonny , Daneault Benoit , Rinfret Stéphane 
Published: December 2019

AbstractChronic total occlusion (CTO) percutaneous coronary intervention (PCI) is a technically challenging procedure. In failed cases, plaque modification strategy (also known as “investment procedure”), defined as the intentional dilation of the subintimal space through the CTO segment, can be applied. The typical dilation device used in this strategy is a regular angioplasty balloon (either semi‐ or noncompliant). Performing this technique with a drug‐coated balloon (DCB) may facilitate a staged procedure by promoting a better vessel healing. Herein, we present three cases of failed CTO PCI, managed with DCB plaque modification, and their follow‐up staged procedure.
Aortic stenosis and the pulse contour: A true marker of severity?
Authors: Eleid Mackram F. , Nishimura Rick A. 
Published: December 2019

AbstractThe aortic pulse contour displays characteristic changes associated with the progression of aortic stenosis (AS). A diminished and delayed aortic pulse contour is indicative of significant AS, but the aortic contour may also be affected by factors including aging, hypertension and increased peripheral arterial elastance. This review describes the components of the aortic pulse contour in AS and how it can be affected by different conditions and interventions.
A Facile Method for the Separation of Methionine Sulfoxide Diastereomers, Structural Assignment, and DFT Analysis
Authors: Raskatov Jevgenij A. , Virgil Scott , Lee Hsiau‐Wei , Henling Lawrence M. , Chan Ka , Kuhn Ariel J. , Foley Alejandro R. 
Published: December 2019

AbstractMethionine (Met) oxidation is an important biological redox node, with hundreds if not thousands of protein targets. The process yields methionine oxide (MetO). It renders the sulfur chiral, producing two distinct, diastereomerically related products. Despite the biological significance of Met oxidation, a reliable protocol to separate the resultant MetO diastereomers is currently lacking. This hampers our ability to make peptides and proteins that contain stereochemically defined MetO to then study their structural and functional properties. We have developed a facile method that uses supercritical CO2 chromatography and allows obtaining both diastereomers in purities exceeding 99 %. 1H NMR spectra were correlated with X‐ray structural information. The stereochemical interconversion barrier at sulfur was calculated as 45.2 kcal mol−1, highlighting the remarkable stereochemical stability of MetO sulfur chirality. Our protocol should open the road to synthesis and study of a wide variety of stereochemically defined MetO‐containing proteins and peptides.
Macroscopic Change in Luminescent Color by Thermally Driven Sliding Motion in [3]Rotaxanes
Authors: Inamori Daiki , Masai Hiroshi , Tamaki Takashi , Terao Jun 
Published: December 2019

AbstractSystematic investigation of rotaxane structures has revealed a rational design for thermally driven switching of their macroscopic properties. At low temperature, the luminophore is insulated by the macrocycles and displays monomer emission, whereas at high temperature, the luminophore is exposed owing to a change in the macrocyclic location distribution and interacts with external molecules, affording a thermally driven luminescent color change with high reversibility and responsiveness. This macroscopic switching through efficient thermal sliding was made possible by appropriate tuning of both the macrocycle–luminophore interactions within the rotaxane and the coupling between the excited luminophore and external molecules in an exciplex. The ability to switch properties by a simple and clean thermal stimuli should expand the utilization of rotaxanes as components of thermally driven molecular systems.
Disparities in risk perception of thyroid cancer recurrence and death
Authors: Chen Debbie W. , Reyes‐Gastelum David , Wallner Lauren P. , Papaleontiou Maria , Hamilton Ann S. , Ward Kevin C. , Hawley Sarah T. , Zikmund‐Fisher Brian J. , Haymart Megan R. 
Published: December 2019

BackgroundTo the authors' knowledge, studies regarding risk perception among survivors of thyroid cancer are scarce.MethodsThe authors surveyed patients who were diagnosed with differentiated thyroid cancer from the Surveillance, Epidemiology, and End Results registries of Georgia and Los Angeles County (2632 patients; 63% response rate). The analytic cohort was defined by a ≤5% risk of disease recurrence and mortality (1597 patients). Patients estimated their recurrence and mortality risks separately (increments of 10% and endpoints of ≤5% and ≥95%). Both outcomes were dichotomized between reasonably accurate estimates (risk perception of ≤5% or 10%) versus overestimation (risk perception of ≥20%). Multivariable logistic regression was used to identify factors associated with risk overestimation, and the relationships between overestimation and both worry and quality of life were evaluated.ResultsIn the current study sample, 24.7% of patients overestimated their recurrence risk and 12.5% overestimated their mortality risk. A lower educational level was associated with overestimating disease recurrence (≤high school diploma: odds ratio [OR], 1.64 [95% CI, 1.16‐2.31]; and some college: OR, 1.36 [95% CI, 1.02‐1.81]) and mortality (≤high school diploma: OR, 1.86 [95% CI, 1.18‐2.93]) risk compared with those attaining at least a college degree. Hispanic ethnicity was found to be associated with overestimating recurrence risk (OR, 1.44, 95% CI 1.02‐2.03) compared with their white counterparts. Worry about recurrence and death was found to be greater among patients who overestimated versus those who had a reasonably accurate estimate of their risk of disease recurrence and mortality, respectively (P < .001). Patients who overestimated mortality risk also reported a decreased physical quality of life (mean T score, 43.1; 95% CI, 41.6‐44.7) compared with the general population.ConclusionsLess educated patients and Hispanic patients were more likely to report inaccurate risk perceptions, which were associated with worry and a decreased quality of life.
Hierarchically Organized NiCo2O4 Microflowers Anchored on Multiwalled Carbon Nanotubes: Efficient Bifunctional Electrocatalysts for Oxygen and Hydrogen Evolution Reactions
Authors: Umeshbabu Ediga , Hari Krishna Charan P. , Justin Ponniah , Ranga Rao G. 
Published: December 2019

AbstractHierarchical flower‐like NiCo2O4 anchored on multiwalled carbon nanotubes (NiCo2O4‐MCNTs) act as robust bifunctional electrocatalysts towards O2 (OER) and H2 (HER) evolution reactions. The NiCo2O4‐MCNTs hybrid is synthesized in a facile surfactant‐free hydrothermal process, and its flower‐like morphology was shown to consist of 1D nanowires. The MCNT support is beneficial for enhanced reactive sites, efficient charge transfer, and durability of the composite. The material shows low overpotentials of 350 mV and 209 mV for OER and HER, respectively at 10 mA cm−2. Such values are comparable to contemporary noble‐metal catalysts and even lower than reported non‐precious catalysts. Moreover, this hybrid shows high current density, lower Tafel slope, and excellent stability. The synergistic coupling effects between the MCNTs and NiCo2O4 are key factors for the superior catalytic activity of these hybrid materials.
Genetic Factors Influencing Warfarin Dose in Black‐African Patients: A Systematic Review and Meta‐Analysis
Authors: Asiimwe Innocent G. , Zhang Eunice J. , Osanlou Rostam , Krause Amanda , Dillon Chrisly , Suarez‐Kurtz Guilherme , Zhang Honghong , Perini Jamila A. , Renta Jessicca Y. , Duconge Jorge , Cavallari Larisa H. , Marcatto Leiliane R. , Beasly Mark T. , Perera Minoli A. , Limdi Nita A. , Santos Paulo C.J.L. , Kimmel Stephen E. , Lubitz Steven A. , Scott Stuart A. , Kawai Vivian K. , Jorgensen Andrea L. , Pirmohamed Munir 
Published: December 2019

Warfarin is the most commonly used oral anticoagulant in sub‐Saharan Africa. Dosing is challenging due to a narrow therapeutic index and high interindividual variability in dose requirements. To evaluate the genetic factors affecting warfarin dosing in black‐Africans, we performed a meta‐analysis of 48 studies (2,336 patients). Significant predictors forCYP2C9and stable dose included rs1799853 (CYP2C9*2), rs1057910 (CYP2C9*3), rs28371686 (CYP2C9*5), rs9332131 (CYP2C9*6), and rs28371685 (CYP2C9*11) reducing dose by 6.8, 12.5, 13.4, 8.1, and 5.3 mg/week, respectively.VKORC1variants rs9923231 (‐1639G>A), rs9934438 (1173C>T), rs2359612 (2255C>T), rs8050894 (1542G>C), and rs2884737 (497T>G) decreased dose by 18.1, 21.6, 17.3, 11.7, and 19.6 mg/week, respectively, whereas rs7294 (3730G>A) increased dose by 6.9 mg/week. Finally, rs12777823 (CYP2Cgene cluster) was associated with a dose reduction of 12.7 mg/week. Few studies were conducted in Africa, and patient numbers were small, highlighting the need for further work in black‐Africans to evaluate genetic factors determining warfarin response.
Contact mechanical behaviors of radial metal seal for the interval control valve in intelligent well: Modeling and theoretical study
Authors: Yang Yiwei , Zhu Hongwu , He Dongsheng , Du Changcheng , Xu Liangbin , He Yufa , Zheng Yan , Ye Zhewei 
Published: December 2019

AbstractIntelligent wells equipped with the interval control valve (ICV), which have the potential applications to significantly improve oil production or control the water production of wells and fields, are more and more widely utilized in the oilfields. The radial metal seal of an ICV is intended to isolate the flow of produced fluids between the casing annulus and the well tubing. The contact mechanical behaviors of the radial metal seal are essential to the structural design and reliability of ICVs in the intelligent well. In this paper, the two‐dimensional axisymmetric assembly of the radial metal seal and the closure member is abstracted as a combination of interference fit model and cantilever beam model. Based on that, the related theoretical model, between the radial metal seal's contact stress and its independent variables, has been derived. Next, numerically simulations of contact stress between the radial metal seal and the closure member for different independent variables are conducted by the finite element method (FEM) to validate the theoretical model. It is found that the mean absolute value of relative error between the numerical and theoretical results of the contact stress is approximately 10%. Additionally, the structural parameters of the radial metal seal are proposed with the absolute value of relative error <10%. Furthermore, the value of the contact stress based on the cantilever beam model can be used to calculate an approximation theoretical solution. In summary, the proposed theoretical model provides a foundation for the design, improvement, and selection of radial metal seal under the known oilfield conditions.
Experimental determination of the dielectric constant of wheat grain and cluster straw in different moisture contents
Authors: Jafari Mohammad , Chegini Gholamreza , Rezaeealam Behrooz , Shaygani Akmal Amir Abbas 
Published: December 2019

AbstractOne of the new methods in the removal of impurities from the wheat grains is the electrostatic separation of particles based on the differences in their conductivity and permittivity. The moisture content of particles directly influences their electrical properties. In this study, by developing a cylindrical capacitor in an electrical circuit, the electrical capacitance of wheat grain and cluster straw particles in two varieties at four levels of moisture content (8%, 14%, 20%, and 25%) and five frequency levels (1, 10, 20, 100, and 500 kHz) is estimated and their dielectric constant is calculated. Results showed that increasing the moisture content of straw particles and reducing the frequency compared to the seeds had significant effects on dielectric constant. The dielectric constant of grain particles was higher than the straw at lower moisture content and in high values of moisture content, the dielectric constant of straw particles was higher than the seeds.
Connexin 43 deletion in astrocytes promotes CNS remyelination by modulating local inflammation
Authors: Li Tao , Niu Jianqin , Yu Guangdan , Ezan Pascal , Yi Chenju , Wang Xiaorui , Koulakoff Annette , Gao Xing , Chen Xianjun , Sáez Juan C. , Giaume Christian , Xiao Lan 
Published: December 2019

AbstractAs the most abundant gap junction protein in the central nervous system (CNS), astrocytic connexin 43 (Cx43) maintains astrocyte network homeostasis, affects oligodendroglial development and participates in CNS pathologies as well as injury progression. However, its role in remyelination is not yet fully understood. To address this issue, we used astrocyte‐specific Cx43 conditional knockout (Cx43 cKO) mice generated through the use of a hGFAP‐cre promoter, in combination with mice carrying a floxed Cx43 allele that were subjected to lysolecithin so as to induce demyelination. We found no significant difference in the demyelination of the corpus callosum between Cx43 cKO mice and their non‐cre littermate controls, while the remyelination process in Cx43 cKO mice was accelerated. Moreover, an increased number of mature oligodendrocytes and an unaltered number of oligodendroglial lineage cells were found in Cx43 cKO mouse lesions. This indicates that oligodendrocyte precursor cell (OPC) differentiation was facilitated by astroglial Cx43 depletion as remyelination progressed. Underlying the latter, there was a down‐regulated glial activation and modulated local inflammation as well as a reduction of myelin debris in Cx43 cKO mice. Importantly, 2 weeks of orally administrating boldine, a natural alkaloid that blocks Cx hemichannel activity in astrocytes without affecting gap junctional communication, obviously modulated local inflammation and promoted remyelination. Together, the data suggest that the astrocytic Cx43 hemichannel is negatively involved in the remyelination process by favoring local inflammation. Consequently, inhibiting Cx43 hemichannel functionality may be a potential therapeutic approach for demyelinating diseases in the CNS.
A neurocognitive model of perceptual decision‐making on emotional signals
Authors: Dricu Mihai , Frühholz Sascha 
Published: December 2019

AbstractHumans make various kinds of decisions about which emotions they perceive from others. Although it might seem like a split‐second phenomenon, deliberating over which emotions we perceive unfolds across several stages of decisional processing. Neurocognitive models of general perception postulate that our brain first extracts sensory information about the world then integrates these data into a percept and lastly interprets it. The aim of the present study was to build an evidence‐based neurocognitive model of perceptual decision‐making on others' emotions. We conducted a series of meta‐analyses of neuroimaging data spanning 30 years on the explicit evaluations of others' emotional expressions. We find that emotion perception is rather an umbrella term for various perception paradigms, each with distinct neural structures that underline task‐related cognitive demands. Furthermore, the left amygdala was responsive across all classes of decisional paradigms, regardless of task‐related demands. Based on these observations, we propose a neurocognitive model that outlines the information flow in the brain needed for a successful evaluation of and decisions on other individuals' emotions.Highlights
Emotion classification involves heterogeneous perception and decision‐making tasks
Decision‐making processes on emotions rarely covered by existing emotions theories
We propose an evidence‐based neuro‐cognitive model of decision‐making on emotions
Bilateral brain processes for nonverbal decisions, left brain processes for verbal decisions
Left amygdala involved in any kind of decision on emotions