bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Health Education program on health related quality of life among patients with End Stage Renal Disease on hemodialysis and their Caregivers at Ain Shams University Hospital
Authors: Ibrahim A M , Shoman A E , Mady G E , Hassan A M , Mohamed D H 
Published: May 2020

Abstract

Background
Patients with renal failure had poorer quality of life than patients with other chronic diseases such as heart failure, diabetes mellitus and even cancer which makes them more susceptible to withdraw dialysis treatment.

Objectives
The study was conducted to implement a health education program for patients with end stage renal disease on hemodialysis and their caregivers at Ain Shams University Hospital and measure its effect on their quality of life.

Methods
A controlled interventional study was carried out on three phases. A sample of 56 patients on chronic regular hemodialysis and their caregivers (HD) were selected from the two hemodialysis units at Ain Shams university hospital and data were collected at the beginning and after six months of the health education program.

Results
The intervention group of the patients after the intervention reported significant better quality of life scores than the control group in all the domains except in work status, quality of social interaction, sexual function, social support and patient satisfaction and there were statistically significant increases in the intervention group of the caregivers than the control group in social function, emotional well-being, role emotional and mental component summary scores.

Conclusion
The health education and individualized nutritional program had a positive effect on many components of quality of life of the hemodialysis patients and their caregivers
Angiographic study of internal pudendal artery in patients with erectile dysfunction and ischemic heart disease
Authors: Saleh H , Zuelfakkar N , Said K , El-Nahas K 
Published: May 2020

Abstract

Background
ED and coronary artery disease (CAD) have been shown to share common risk factors such as advanced age, diabetes, hypertension and dyslipidemia. ED is emerging as an identifiable risk factor for the subsequent development of cardiovascular events.

Materials and Methods
This study included 20 male patients with ED, who were selected from the andrology clinic after being scheduled to undergo cardiac catheterization at the Department of Cardiology, Ain Shams University. All the patients were subjected to full history taking, general examination, evaluation of the erectile state, risk factor assessment and angiographic study involving coronary and pelvic arteries.

Results
There was a highly significant negative correlation (P = 0.0001) between IIEF score and the percent of obstruction affecting right, left & mean internal pudendal artery (IPA). As regard the relation between IPAs obstruction and coronary arteries obstruction, our results showed a significant correlation between right IPA and right coronary (RCA) obstruction. IIEF score also correlated with the degree of obstruction affecting coronary arteries, showing a negative significant correlation between IIEF score and right coronary artery percent of obstruction.

Conclusion
Erectile dysfunction is an independent risk factor for coronary heart disease, may be through increased atherosclerosis risk. Cardiac assessment is mandatory for patients presented with erectile dysfunction.
Comparative Study on the Efficacy of Intralesional Minoxidil Injection Alone and in Combination versus the Standard Intralesional Corticosteroid Injection in the Treatment of Alopecia Areata
Authors: Abdallah M A , Soltan M Y , Mohammed R S 
Published: May 2020

Abstract

Background
Alopecia areata (AA) is a common, inflammatory, non-scarring type of hair loss. Although hair loss can affect all hair bearing sites, patchy alopecia affecting the scalp is the most common type. Hair loss may progress to alopecia totalis (AT) which is complete balding at the scalp, or to alopecia universalis (AU), describing loss of all hairs on the scalp and body. Consequently, this can cause a devastating emotions effects on patients and may be expose them to psychological comorbidities such as depression, anxiety and social phobia.

Objectives
To assess the efficacy and safety of intradermal delivery of minoxidil 5% alone and in combination with intralesional triamcinolone acetonide for treatment of alopecia areata.

Patients and Methods
This study is prospective randomized intra-patients comparative control clinical trail that include 20 Egyptian patients suffering from multiple patches of AA during December 2017 till November 2018 which approved by The Dermatology Research Ethical Committee, Faculty of Medicine, Ain Shams University. Each patient had at least 5 scalp patches of approximately similar size (minimally 3 cm2) with a severity of alopecia tool (SALT) score up to S2 (less than 50% of scalp involvement) either in stable or progressive course. Patients were recruited from outpatient clinic of Dermatology, Ain Shams University Hospital and Al-houd Al-marsoud Hospital and informed written consent was obtained from all of them after explanations the study objective before enrollment in it.

Results
Considering the side effects of the treatment, all patients in all groups develop different types of side effects only the intolerable pain of injection was common between them and it was statistically not significant in comparison between the treatment groups. All the treatment groups showed significant reduction in dermoscopic finding of AA after treatment except in control group.

Conclusion
Standard intralesional corticosteroids are the mainstay first line treatment of patchy alopecia that involving less than 50% of the scalp and for cosmetics areas such as beard and eyebrows.
Assessment of Plasma Homocysteine in Acne Patients isotretinoim Therapy
Authors: Sallam M A , Alzawahry K M A , Haki R M Z 
Published: May 2020

Abstract

Background
Acne is a chronic inflammatory disorder of the pilosebaceous unit. Oral isotretinoin is a highly effective treatment for patients with moderate and severe, but causes significant side effects.

Objective
To estimate homocysteine level in acne patients after treatment with isotretinoin.

Patients and Methods
The prospective study was conducted at Ain Shams University Faculty of Medicine, Egypt, from June 2017 to November 2017, including male or non-pregnant female patients more than 18 years of age, categorized by the Global Evaluation Acne (GEA) into 22 patients with moderate acne vulgaris and 22 patients with severe acne. Isotretinoin was started in a dosage of 0.5 mg/kg/day, and 1.0mg/kg/day in moderate and severe acne patients respectively. Baseline homocysteine level, liver function tests, serum cholesterol and lipid profile were tested before and after 3 months.

Results
There was significant difference (p = 0.001) in homocysteine level among all cases Moreover, homocysteine serum level in patient's group who received high dose isotretinoin (1 mg/kg/d) showed highly significant results (p = 0.001) in contrast to patient's group who received low dose isotretinoin (0.5 mg/kg/d) = 0.003). A significant increase in lipid profile and liver function test was seen in all cases.

Conclusion
low dose isotretinoin seems to have less side effects on basic laboratory data such as CBC, liver function tests, lipid profile and homocysteine serum levels than high dose.
Autologous Plasma Filler in Treatment of Nasolabial Folds
Authors: Abdelfattah N S , Elhusseiny R M , Mahmoud A A 
Published: May 2020

Abstract

Background
There is an increasing demand for aesthetic correction of deep NLFs. Dermal fillers are one of the nonsurgical options for soft tissue augmentation, plasma filler is a recent technique tried in soft tissue augmentation. This procedure could be performed on an outpatient basis at a moderate cost, without any rejection reactions.

Objective
The presented study aimed to confirm the efficacy and safety of autologous plasma filler in treating nasolabial fold wrinkles.

Subjects and Methods
The present study included 40 females attended the Dermatology outpatient clinic of Ain Shams University Hospitals from March 2017 to November 2017. The age of patients ranged from 20 to 60 years old, with the mean age of 38.60 years old ± 11.48 SD.

Results
The overall success of our study was defined according to clinical improvement of NLFs subjectively by patients' satisfaction score which showed that 42.5% of patients rated their improvement as excellent, 35% as good and 22.5% as poor. The mean of WSRS decreased significantly from (3.20 ± 0.96) before treatment to (1.50 ±0.630) after 4 weeks of the treatment session. Furthermore, the mean value of GAIS scores 2 weeks after treatment session was (4.47 + 0.730) then become (4.03±0.964) 4 weeks after the treatment session.

Conclusion
In conclusion, Treatment with plasma filler injection resulted in significant improvement of NLFs with minimal complications.
Seminal Plasma Clusterin as a Biomarker for Spermatogenesis in Varicocele Patients before and after Varicocelectomy
Authors: Saleh H M A , Afify A A , Ahmed W A , Daruish M S 
Published: May 2020

Abstract

Introduction
a varicocele is an abnormally dilated pampiniform plexus of veins. Hyperthermia, oxidative stress, and elevated apoptotic index have been described in men with variocele and infertility. Clusterin (Clu) is a chaperone-like glycoprotein which is synthesized by Sertoli cells in high concentrations and is deposited onto the membranes of and mature spermatozoa, giving rise to the possibility that it has a role in sperm development. Secreted form of clusterin is a powerful anti-apoptotic.

Aim
To explore clusterin level in seminal plasma of infertile men with varicocele in comparison to normal healthy fertile subjects and to compare the seminal plasma clusterin level before and after varicocelectomy

Methods
The study included 25 patients suffering from varicocele with infertility (whether primary or secondary) for 12 months, and 10 healthy volunteers of matched age and sex as control. For all the patients Sub-inguinal varicocelectomy was done. Semen analysis, and seminal plasma clusterin assay were carried out before and three months after varicocelectomy.

Results
there was a statistically significant difference between patients and controls as regards sperm count, progressive motility, and seminal plasma clusterin (P &lt; 0.01). Three months after varicocelectomy, the sperm count had a highly significant improvement in the patient’s group (Mean= 17.90 + 8.86) compared to a preoperative count (Mean= 11.43 + 7.56). There was a highly significant improvement in post-operative progressive motility in the patient’s group (Mean= 34.5 + 20.2) compared to a preoperative progressive motility (Mean= 22.05 + 15.5).
Post-operative clusterin showed a highly significant elevation in the patient’s group postoperative (Mean= 10.73 + 4.5) compared to a preoperative clusterin (Mean= 6.68 + 3.8).

Conclusion
Based on our study we could suggest another way of contribution of varicocele to male infertility by affecting seminal plasma clusterin level.
Evaluation of Topical Photo-Enhancer Assisted Intense Pulsed Light versus Methylene Blue Assisted Intense Pulsed Light for Treatment of Seborrheic Keratosis
Authors: Mohammed G F , Alzawahry K M A , Atef M M , Salahuldin I M 
Published: May 2020

Abstract

Background
seborrheic keratosis is one of the most common benign epidermal tumors that affects both sexes equally, and usually arises in individuals older than 50 years. It presents as sharply demarcated, slightly raised brownish patches or plaques, usually on sun-exposed surfaces of the skin. The clinical presentation can be quite variable and includes clinical variants, such as stucco keratosis and dermatosis papulosa nigra.

Aim of the Work
to evaluate the efficacy and safety of topical carbon gel photo-enhancer assisted intense pulsed light versus methylene blue assisted intense pulsed light photodynamic therapy for treatment of Seborrheic Keratosis.

Patients and Methods
this is a comparative prospective study that included thirty patients of skin types III to V Fitzpatrick class having multiple Seborrheic Keratosis lesions with no sex or age predilection. They were randomly recruited from Dermatology out-patient clinic of Ain –Shams University Hospitals, during period from June 2017 till March 2018. The study was approved by Research Ethical Committee of Ain Shams University and fulfilled all the ethical aspects required for human research.

Results
this denoted that the methylene blue-mediated photodynamic therapy (MB-PDT) (liposomal-loaded methylene blue gel 10%).and topical carbon gel photo-enhancer assisted intense pulsed light). could be effective in treating patients with Sks. Our findings denote the efficacy of them in curing multiple Sk lesions. The efficacy of methylene blue-mediated photodynamic therapy (MB-PDT) (liposomal-loaded methylene blue gel 10%).

Conclusion
that Intense Light Pulse using liposomal-loaded MB and Topical carbon suspension-assisted IPL treatment could be a good option for patients with indistinct pigmented or thick melanogenesic lesions. Adverse reactions to this treatment were minimal and the results acceptable, though appropriate lesions need to be chosen care- fully.
Internalizing Behavioral Problems in Children with Specific Language Impairment
Authors: Hassan S , Hegazi M , Ghandour H , Abdelrazek G , Elrefaie D 
Published: May 2020

Abstract

Background
Specific language impairment (SLI) occurs when children present language maturation, at least 12 months behind their chronological age in the absence of sensory or intellectual deficits, pervasive developmental disorders, evident cerebral damage, and adequate social and emotional conditions. Internalizing behavior is actions that are taken out toward the self. The symptoms of internalizing behavior problems are depression, anxiety, somatic complaints and withdrawal.

Aim of the Work
This study aimed to investigate the presence of internalizing behavioral problems among SLI and their frequencies if present.

Patients and methods
We assessed SLI by PLS-4 and assessed internalizing behavioral problems with CBCL 1 1/5-5. Fifty children with SLI with an age range of (4-5 years old), divided into 2 subgroups according to the type of SLI, are compared to fifty children with normal language development with the same age and gender regarding internalizing behavioral problems.

Results
SLI group had more internalizing behavioral problems than control group and there is significant association between behavioral problems and the severity of language deficits.

Conclusion
the most frequently behavioral problem found in preschool (SLI) children were withdrawn and anxiety, which need therapeutic interventions to remediate them.
The Effectiveness of the Photoangiolytic Potassium Titanyl Phosphate (KTP) Laser in Managing Vocal Folds Reinke’s Edema A Systematic Review
Authors: Saad M N , Elshoubary A M , Hassan S M , Khodeir M S 
Published: May 2020

Abstract

Background
Recently, photoangiolytic potassium titanyl phosphate (KTP) laser treatment has been proposed as an alternative treatment for managing Reinke’s edema. Unlike traditional methods that involve the physical removal of the lesion, the KTP laser causes lesion regression by disrupting the blood supply through targeting the oxyhemoglobin. Moreover, KTP could be used as an office-based procedure, indicating its advantage over other operating room surgical procedures, with lower cost and avoidance of the potential complications of microlaryngoscopy.

Aim
The aim of this work is to conduct a systematic review on the effectiveness of the photoangiolytic KTP Laser as a surgical method for treatment of patients with Reinke’s edema.
Study Design: This was a systematic review.

Methods
Two electronic databases of (PubMed and Cochrane Library) were searched for articles. Relevant studies were further evaluated and studies that met inclusion criteria were reviewed and included.

Results
The literature search yielded 167 studies. 25 articles were further evaluated to be included. Three studies met all the inclusion criteria and were chosen for the review. The studies investigated the effectiveness of using Photoangiolytic KTP Laser in the management of Rienke’s edema.

Conclusion
The current systematic review suggested that photoangiolytic KTP Laser has not yet proven as an effective approach for treatment of Reinke’s edema and furthermore studies are needed to assess its effectiveness.
Assessment of subtypes of dyslexic dysgraphia
Authors: Mohamed D M , Rifaie N A , Hassan S M , Elfeky Y H 
Published: May 2020

Abstract

Background
Writing requires a complex set of motor and information processing skills. It requires not only the ability to organize and express ideas in the mind but it also requires the ability to get muscles in hands and fingers to form these ideas, letter by letter, on paper. Many people have poor handwriting, but dysgraphia is more serious. It's a neurological disorder that generally appears when children are first learning to write and is showing increased incidence among young children.

Aim of the Work
is to make a depth assessment of the developmental dyslexic dysgraphia to clarify its subtypes (surface and deep dysgraphia).

Patients and Methods
Spelling and copying tasks included in Modified Arabic Dyslexia Screening Test (MADST) were applied on the subjects of this study who comprised a convenient sample of 40 children diagnosed as being dyslexic ranging in age from 8-10 years.

Results
There was statistically significant difference between the mean scores of children with surface and deep dysgraphia regarding spelling of regular sense, irregular sense words and nonsense words.

Conclusion
it was proved that dyslexic dysgraphia which is common among young Egyptian children could be further subdivided into surface and deep dysgraphia.
Incidence of Attention-Deficit/Hyperactivity Disorder in Learning Disabled Children, A Systematic Review
Authors: Mohamed H A , Khodeir M S , El-sady S R 
Published: May 2020

Abstract

Background
Children diagnosed with learning disability (LD) have a high incidence of psychiatric comorbidities especially Attention-Deficit/Hyperactivity Disorder (ADHD). These comorbidities are either a direct consequence of the same deficits in the central processing patterns that generate the learning problems, or they tend to stress the role of frustration and failure in academic achievement. These difficulties are claimed to move a vicious circle that leads the child towards ever-greater cognitive and social–emotional impoverishment.

Aim
The aim of this work is to conduct a systematic review of ADHD as a comorbid condition in learning disabled children to determine its incidence in learning disabled children in order to estimate the size of the problem to be able to delineate an efficient program in therapeutic intervention later.

Study design
This was a systematic review.

Methods
Two electronic databases (PubMed and Science Direct) were searched for articles. Relevant studies were further evaluated and studies that met inclusion criteria were reviewed.

Results
The literature search yielded 593 studies. Twenty-eight articles were further evaluated to be included. Five studies met all inclusion criteria and were chosen for review. The studies provide prevalence of ADHD in learning disabled children. We have found higher scores of ADHD in learning disabled children than in the normal population, in all the included studies. The studies reviewed demonstrated the effect of this comorbidity and the importance of its diagnosis for improvement of prognosis of the learning disability.

Conclusion
The current systematic review determines the probable prevalence of the ADHD in learning disabled children.
Comparison between lip-reading ability in normal and hearing impaired children
Authors: Saad A M , Hegazi M A , Khodeir M S 
Published: May 2020

Abstract

Background
Lip-reading is considered an important skill which varies considerably among normal hearing and hearing impaired (HI) children. It helps HI children to perceive speech, acquire spoken language and acquire phonological awareness. Speech perception is considered to be a multisensory process that involves attention to auditory signals as well as visual articulatory movements. Integration of auditory and visual signals occurs naturally and automatically in normal individuals across all ages. Many researches suggested that normal hearing children use audition as the primary sensory modality for speech perception, whereas HI children use lip-reading cues as the primary sensory modality for speech perception.

Aim of the Work
The aim of this study is to compare the lip-reading ability between normal and HI children.

Participants and methods
This is a comparative descriptive case control study. It was applied on 60 hearing impaired children (cases) and 60 normal hearing children (controls) of the same age and gender. The age range was (3-8 years). The Egyptian Arabic Lip-reading Test was applied to all children.

Results
There was statistically significant difference between the total mean scores of the EALRT between normal and HI children.

Conclusion
The results of the study proved that normal children are better lip-readers than HI children of the matched age range.
Significance and relation of vitamin D levels in head and neck cancers
Authors: Mahmoud O , Adly A , Askoura A , Abuelela S A , Salah S 
Published: May 2020

Abstract

Background
Vitamin D and its metabolites reduce the incidence of various cancers including head and neck SCC by inhibiting tumor angiogenesis, stimulating mutual adherence of cells, and enhancing intercellular communication, thereby strengthening the inhibition of cellular proliferation. Epidemiologic and case-control studies have demonstrated that low vitamin D levels are associated with head and neck SCC risk. Some studies showed that patients with HNSCC who received vitamin D at the time of diagnosis had diminished peripheral blood and intratumoral levels of immunosuppressive CD34+ cells and increased levels of mature dendritic cells. In addition, they showed the quantitative increase of the immune cells within the HNSCC tissue following vitamin D treatment.

Aim
to investigate the significance and relation of vitamin D levels in head and neck cancers.

Patients and Methods
The study included 100 participants; they were categorized into two groups. Group A comprised 50 patients (40 males and 10 females) with various HNSCC sites, and with a mean age of 53.04±13.56 years. Group B comprised 50 (32 males and 18 females) sex-matched and age-matched healthy volunteers as controls, and with a mean age of 42.04±14.09 years. In total, 22 participants of group A were smokers while 28 of the control group (group B) were smokers. Both groups were subjected to Lab detection of vitamin D level.

Conclusion
This study showed that there is a non-significant relation between vitamin D levels and the different types of head and neck cancers. But vitamin D deficiency may expose the patients to increased risk of therapy-related morbidity and poor outcome; as a significant relation between vitamin D levels, HCV and Hb levels among the cases is reported. It may constitute an inexpensive prophylactic and cost-effective option in the therapeutic armamentarium as a synergistic agent to traditional treatment options.