bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variations in factors associated with healthcare providers’ intention to engage in interprofessional shared decision making in home care: results of two cross-sectional surveys
Authors: Adekpedjou Rhéda , Haesebaert Julie , Stacey Dawn , Brière Nathalie , Freitas Adriana , Rivest Louis-Paul , Légaré France 
Published: March 2020

Abstract
Background
DOLCE (Improving Decision making On Location of Care with the frail Elderly and their caregivers) was a post-intervention clustered randomised trial (cRT) to assess the effect of training home care teams on interprofessional shared decision-making (IP-SDM). Alongside the cRT, we sought to monitor healthcare providers’ level of behavioural intention to engage in an IP-SDM approach and to identify factors associated with this intention.

Methods
We conducted two cross-sectional surveys in the province of Quebec, Canada, one each at cRT entry and exit. Healthcare providers (e.g. nurses, occupational therapists and social workers) in the 16 participating intervention and control sites self-completed an identical paper-based questionnaire at entry and exit. Informed by the Integrated model for explaining healthcare professionals’ clinical behaviour by Godin et al. (2008), we assessed their behavioural intention to engage in IP-SDM to support older adults and caregivers of older adults with cognitive impairment to make health-related housing decisions. We also assessed psychosocial variables underlying their behavioural intention and collected sociodemographic data. We used descriptive statistics and linear mixed models to account for clustering.

Results
Between 2014 and 2016, 271 healthcare providers participated at study entry and 171 at exit. At entry, median intention level was 6 in a range of 1 (low) to 7 (high) (Interquartile range (IQR): 5–6.5) and factors associated with intention were social influence (β = 0.27, P <  0.0001), beliefs about one’s capabilities (β = 0.43, P <  0.0001), moral norm (β = 0.31, P <  0.0001) and beliefs about consequences (β = 0.21, P <  0.0001). At exit, median intention level was 5.5 (IQR: 4.5–6.5). Factors associated with intention were the same but did not include moral norm. However, at exit new factors were kept in the model: working in rehabilitation (β = − 0.39, P = 0.018) and working as a technician (β = − 0.41, P = 0.069) (compared to as a social worker).

Conclusion
Intention levels were high but decreased from entry to exit. Factors associated with intention also changed from study entry to study exit. These findings may be explained by the major restructuring of the health and social care system that took place during the 2 years of the study, leading to rapid staff turnover and organisational disturbance in home care teams. Future research should give more attention to contextual factors and design implementation interventions to withstand the disruption of system- and organisational-level disturbances.

Trial registration
Clinicaltrials.gov (NCT02244359). Registered on September 19th, 2014.
Diagnostic value of fibrinogen to prealbumin ratio and gamma-glutamyl transpeptidase to platelet ratio in the progression of AFP-negative hepatocellular carcinoma
Authors: Huang Li , Mo Zhuning , Hu Zuojian , Zhang Linyan , Qin Shanzi , Qin Xue , Li Shan 
Published: March 2020

Abstract
Background
This study aimed to comprehensively assess the diagnostic value of fibrinogen to prealbumin ratio (FPR) and gamma-glutamyl transpeptidase to platelet ratio (GPR) as single markers or in combination in patients with alpha-fetoprotein-negative (AFP-negative) hepatocellular carcinoma (HCC).

Methods
A total of 199 healthy controls and 515 AFP-negative patients were enrolled in this study, including 180 HCC inpatients, 151 liver cirrhosis (LC) patients, and 184 chronic hepatitis (CH) cases. Mann–Whitney U or Kruskal–Wallis H test were used to analyze differences between groups in laboratory parameters and clinicopathological features. The diagnostic value of FPR and GPR, alone or in combination, in AFP-negative HCC (AFP-NHCC) patients was determined via a receiver operating characteristic (ROC) curve.

Results
The levels of FPR and GPR were gradually increased in the development of AFP-NHCC and positively correlated with the tumor size and Barcelona Clinic Liver Cancer (BCLC) stages. Moreover, GPR was associated with Edmondson–Steiner grades. After univariate logistic regression analysis, FPR and GPR remained independent predictors of adverse outcomes. The combination of FPR and GPR had a good ability to detect AFP-NHCC from the control group (area under curve [AUC] = 0.977), AFP-negative CH (AUC = 0.745), and AFP-negative LC (AUC = 0.666). FPR combined with GPR possessed a larger area (0.943, 0.971) and sensitivity (87.50%, 89.81%) than FPR or GPR alone for differentiating AFP-NHCC with tumor size < 3 cm or at the BCLC-A stage.

Conclusions
The pretreatment levels of FPR and GPR played vital roles in the development of AFP-NHCC, especially in patients with early or small AFP-NHCC.
Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender
Authors: Liu Xing Zhen , Wang Jun Min , Ji Yi Xin , Zhao Dong Bao 
Published: March 2020

Abstract
Background
Systemic inflammation may be involved in the formation and progression of thyroid nodule (TN). The aim of this large-scale study was to investigate the association of several simple inflammatory markers with the presence and size of TN.

Methods
A total of 133,698 adults were included for the current analysis. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) were calculated. The logistic regression was used to explore the association of the four markers with the presence and size of TN.

Results
The prevalence of TN was 55.1% among females and 44% among males; 13% of women and 8% of men had non-micronodule. In women, MHR and PLR were significantly associated with the presence of TN and non-micronodule; in men, MHR and NLR were significantly associated with the presence of TN and non-micronodule.

Conclusions
As a low-cost, simple, and reproducible inflammatory marker, MHR is strongly associated with the presence and size of TN irrespective of the gender.
Fingolimod-associated macular edema controlled with nepafenac non-steroidal anti-inflammatory opthalmologic applications
Authors: Husmann Rachel , Davies John B. , Ghannam Malik , Berry Brent , Kelkar Praful 
Published: March 2020

Abstract
Background
Fingolimod, an immunomodulatory agent, is used for the treatment of relapsing–remitting multiple sclerosis (RRMS). Fingolimod-associated macular edema (FAME) is a known complication with an incidence of 0.4%. The current recommendation for treatment of FAME is cessation of fingolimod. There are few case reports with management of FAME with steroid eye drops.

Case presentation
A 38-year-old Caucasian female patient with history of relapsing–remitting multiple sclerosis (RRMS) and treated with fingolimod developed Fingolimod-associated macular edema (FAME). Nevertheless, FAME was successfully treated with nonsteroidal anti-inflammatory eye drops without discontinuation of fingolimod.

Conclusion
FAME may be managed with non-steroidal eye drops without discontinuation of fingolimod in appropriate patient monitored with close follow up.
Magnetic core–shell nanowires as MRI contrast agents for cell tracking
Authors: Martínez-Banderas Aldo Isaac , Aires Antonio , Plaza-García Sandra , Colás Lorena , Moreno Julián A. , Ravasi Timothy , Merzaban Jasmeen S. , Ramos-Cabrer Pedro , Cortajarena Aitziber L. , Kosel Jürgen 
Published: March 2020

Abstract
Background
Identifying the precise location of cells and their migration dynamics is of utmost importance for achieving the therapeutic potential of cells after implantation into a host. Magnetic resonance imaging is a suitable, non-invasive technique for cell monitoring when used in combination with contrast agents.

Results
This work shows that nanowires with an iron core and an iron oxide shell are excellent materials for this application, due to their customizable magnetic properties and biocompatibility. The longitudinal and transverse magnetic relaxivities of the core–shell nanowires were evaluated at 1.5 T, revealing a high performance as T2 contrast agents. Different levels of oxidation and various surface coatings were tested at 7 T. Their effects on the T2 contrast were reflected in the tailored transverse relaxivities. Finally, the detection of nanowire-labeled breast cancer cells was demonstrated in T2-weighted images of cells implanted in both, in vitro in tissue-mimicking phantoms and in vivo in mouse brain. Labeling the cells with a nanowire concentration of 0.8 μg of Fe/mL allowed the detection of 25 cells/µL in vitro, diminishing the possibility of side effects. This performance enabled an efficient labelling for high-resolution cell detection after in vivo implantation (~ 10 nanowire-labeled cells) over a minimum of 40 days.

Conclusions
Iron-iron oxide core–shell nanowires enabled the efficient and longitudinal cellular detection through magnetic resonance imaging acting as T2 contrast agents. Combined with the possibility of magnetic guidance as well as triggering of cellular responses, for instance by the recently discovered strong photothermal response, opens the door to new horizons in cell therapy and make iron-iron oxide core–shell nanowires a promising theranostic platform.
Sialidase NEU1 suppresses progression of human bladder cancer cells by inhibiting fibronectin-integrin α5β1 interaction and Akt signaling pathway
Authors: Zhou Xiaoman , Zhai Yanhong , Liu Changmei , Yang Ganglong , Guo Jia , Li Guang , Sun Chengwen , Qi Xiaowei , Li Xiang , Guan Feng 
Published: March 2020

Abstract
Background
Sialic acids are widely distributed in animal tissues, and aberrantly expressed in a variety of cancer types. High expression of sialic acid contributes to tumor aggressiveness by promoting cell proliferation, migration, angiogenesis, and metastasis. Sialidases are responsible for removal of sialic acids from glycoproteins and glycolipids.

Methods
N-glycomics of bladder cancer cells were detected by MALDI-TOF mass spectrometry. Sialic acid modification in bladder cancer tissue was determined by lectin blot. The down-regulation of NEU1 in bladder cancer cells was determined by high resolution liquid chromatography mass spectrometry (HR LC-MS). The effects of sialidase NEU1 expression on proliferation and apoptosis of human bladder cancer cells were examined by western blot, RT-PCR, confocal imaging and flow cytometry. Moreover, the function of sialic acids on fibronectin-integrin α5β1 interaction were assayed by immunoprecipitation and ELISA. The importance of NEU1 in tumor formation in vivo was performed using BALB/c-nu mice. Expression of NEU1 in primary human bladder cancer tissue samples was estimated using bladder cancer tissue microarray.

Results
(1) Downregulation of NEU1 was primarily responsible for aberrant expression of sialic acids in bladder cancer cells. (2) Decreased NEU1 expression was correlated with bladder cancer progression. (3) NEU1 overexpression enhanced apoptosis and reduced proliferation of bladder cancer cells. (4) NEU1 disrupted FN-integrin α5β1 interaction and deactivated the Akt signaling pathway. (5) NEU1 significantly suppressed in vivo tumor formation in BALB/c-nu mice.

Conclusions
Our data showed that NEU1 inhibited cancer cell proliferation, induced apoptosis, and suppressed tumor formation both in vitro and in vivo, by disrupting interaction of FN and integrin β1 and inhibiting the Akt signaling pathway. Our observations indicate that NEU1 is an important modulator of the malignant properties of bladder cancer cells, and is a potential therapeutic target for prognosis and treatment of bladder cancer.

Graphical abstract
MicroRNAs expressed by human cytomegalovirus
Authors: Zhang Lichen , Yu Jiaqi , Liu Zhijun 
Published: March 2020

Abstract
Background
MicroRNAs (miRNAs) are small non-coding RNAs about 22 nucleotides in length, which play an important role in gene regulation of both eukaryotes and viruses. They can promote RNA cleavage and repress translation via base-pairing with complementary sequences within mRNA molecules.

Main body
Human cytomegalovirus (HCMV) encodes a large number of miRNAs that regulate transcriptions of both host cells and themselves to favor viral infection and inhibit the host’s immune response. To date, ~ 26 mature HCMV miRNAs have been identified. Nevertheless, their roles in viral infection are ambiguous, and the mechanisms have not been fully revealed. Therefore, we discuss the methods used in HCMV miRNA research and summarize the important roles of HCMV miRNAs and their potential mechanisms in infection.

Conclusions
To study the miRNAs encoded by viruses and their roles in viral replication, expression, and infection will not only contribute to the planning of effective antiviral therapies, but also provide new molecular targets for the development of antiviral drugs.
Retrospective data analyses of social and environmental determinants of malaria control for elimination prospects in Eritrea
Authors: Mihreteab Selam , Lubinda Jailos , Zhao Bingxin , Rodriguez-Morales Alfonso J. , Karamehic-Muratovic Ajlina , Goitom Aman , Shad Muhammad Yousaf , Haque Ubydul 
Published: March 2020

Abstract
Background
The present study focuses on both long- and short-term malaria transmission in Eritrea and investigates the risk factors. Annual aggregates of information on malaria cases, deaths, diagnostics and control interventions from 2001 to 2008 and monthly reported data from 2009 to 2017 were obtained from the National Malaria Control Programme. We used a generalized linear regression model to examine the associations among total malaria cases, death, insecticide-treated net coverage, indoor residual spraying and climatic parameters.

Results
Reduction in malaria mortality is demonstrated by the milestone margins of over 97% by the end of 2017. Malaria incidence likewise declined during the period (from 33 to 5 per 1000 population), representing a reduction of about 86% (R2 = 0.3) slightly less than the decline in mortality. The distribution of insecticide treated nets generally declined between 2001 and 2014 (R2 = 0.16) before increasing from 2015 to 2017, while the number of people protected by indoor residual spraying slightly increased (R2 = 0.27). Higher rainfall was significantly associated with an increased number of malaria cases. The covariates rainfall and temperature are a better pair than IRS and LLIN to predict incidences. On the other hand, IRS and LLIN is a more significant pair to predict mortality cases.

Conclusions
While Eritrea has made significant progress towards malaria elimination, this progress should be maintained and further improved. Distribution, coverage and utilization of malaria control and elimination tools should be optimized and sustained to safeguard the gains made. Additionally, consistent annual performance evaluation of malaria indicators would ensure a continuous learning process from gains/threats of epidemics and resurgence in regions already earmarked for elimination.
Understanding visual lip-based biometric authentication for mobile devices
Authors: Wright Carrie , Stewart Darryl William 
Published: March 2020

AbstractThis paper explores the suitability of lip-based authentication as a behavioural biometric for mobile devices. Lip-based biometric authentication is the process of verifying an individual based on visual information taken from the lips while speaking. It is particularly suited to mobile devices because it contains unique information; its potential for liveness over existing popular biometrics such as face and fingerprint and lip movements can be captured using a device’s front-facing camera, requiring no dedicated hardware. Despite its potential, research and progress into lip-based biometric authentication has been significantly slower than other biometrics such as face, fingerprints, or iris.This paper investigates a state-of-the-art approach using a deep Siamese network, trained with the triplet loss for one-shot lip-based biometric authentication with real-world challenges. The proposed system, LipAuth, is rigourously examined with real-world data and challenges that could be expected on lip-based solution deployed on a mobile device. The work in this paper shows for the first time how a lip-based authentication system performs beyond a closed-set protocol, benchmarking a new open-set protocol with an equal error rates of 1.65% on the XM2VTS dataset.New datasets, qFace and FAVLIPS, were collected for the work in this paper, which push the field forward by enabling systematic testing of the content and quantities of data needed for lip-based biometric authentication and highlight problematic areas for future work. The FAVLIPS dataset was designed to mimic some of the hardest challenges that could be expected in a deployment scenario and include varied spoken content, miming and a wide range of challenging lighting conditions. The datasets captured for this work are available to other university research groups on request.
Analysis of computer network attack based on the virus propagation model
Authors: He Yanshan , Wang Ting , Xie Jianli , Zhang Ming 
Published: March 2020

AbstractThe conventional method can make a reasonable analysis of common network attacks, but the reliability of the analysis is low under the virus propagation model. This paper proposes a new research method of computer network attack analysis based on the virus propagation model. Based on the relationship between the framework and daemon, the framework of the model for computer network attack analysis is set up, the attack analysis technology of computer network is determined, and the construction of the model for computer network attack analysis is completed. Computer attack objects and computer attack process are analyzed, and computer network attack analysis is carried out. Using the coverage test and the uncertainty test, the parameters of the reliability calculation variables are measured and the reliability calculation formula is replaced. It is concluded that the designed method of computer network attack analysis is 47.15% more reliable than the conventional analysis method, and is suitable for the network attack analysis under the virus propagation model.
Journal impact factor, trial effect size, and methodological quality appear scantly related: a systematic review and meta-analysis
Authors: Saginur Michael , Fergusson Dean , Zhang Tinghua , Yeates Karen , Ramsay Tim , Wells George , Moher David 
Published: March 2020

Abstract
Background
As systematic reviews’ limited coverage of the medical literature necessitates decision-making based on unsystematic review, we investigated a possible advantage of systematic review (aside from dataset size and systematic analysis): does systematic review avoid potential bias in sampling primary studies from high impact factor journals? If randomized controlled trials (RCTs) reported in higher-impact journals present different treatment benefits than RCTs reported in lower-impact journals, readers who focus on higher-impact journals for their rapid literature reviews may introduce bias which could be mitigated by complete, systematic sampling.

Methods
We randomly sampled Cochrane Library (20 July 2005) treatment reviews that measured mortality as a binary outcome, published in English or French, with at least five RCTs with one or more deaths. Our domain-based assessment of risk of bias included funding source, randomness of allocation sequence, blinding, and allocation concealment. The primary analysis employed logistic regression by a generalized linear model with a generalized estimating equation to estimate the association between various factors and publication in a journal with a high journal impact factor (JIF).

Results
From the 29 included systematic reviews, 189 RCTs contributed data. However, in the primary analyses comparing RCT results within meta-analyses, there was no statistically significant association: unadjusted odds of greater than 50% mortality protection in high-JIF (> 5) journals were 1.4 (95% CI 0.42, 4.4) and adjusted, 2.5 (95% CI 0.6, 10). Elements of study quality were weakly, inconsistently, and not statistically significantly correlated with journal impact factor.

Conclusions
Journal impact factor may have little to no association with study results, or methodological quality, but the evidence is very uncertain.
On a reverse extended Hardy–Hilbert’s inequality
Authors: Huang Zhenxiao , Shi Yanping , Yang Bicheng 
Published: March 2020

AbstractBy the use of the weight coefficients, the idea of introducing parameters and the Euler–Maclaurin summation formula, a reverse extended Hardy–Hilbert inequality and the equivalent forms are given. The equivalent statements of the best possible constant factor related to a few parameters and some particular cases are also considered.
Blow-up analysis for two kinds of nonlinear wave equations
Authors: Li Hengyan , Sun Junling , Zhao Xin 
Published: March 2020

AbstractIn this paper, we discuss the blow-up and lifespan phenomenon for the following wave equation with variable coefficient:
$$ u_{tt}(t,x)-\mathbf{div}\bigl(a(x)\mathbf{grad}u(t,x) \bigr)=f(u,Du,D_{x}Du), \quad x \in \mathbf{R}^{n}, t>0, $$utt(t,x)−div(a(x)gradu(t,x))=f(u,Du,DxDu),x∈Rn,t>0, with small initial data, where $a(x)>0$a(x)>0, $Du=(u_{x_{0}},u_{x_{1}},\ldots ,u_{x_{n}})$Du=(ux0,ux1,…,uxn) and $D_{x}Du=(u_{x_{k}x_{l}}, k,l=0,1,\ldots ,n, k+l\geq 1)$DxDu=(uxkxl,k,l=0,1,…,n,k+l≥1).Then we find a new phenomenon. The Cauchy problem
$$ u_{tt}(t,x)-\triangle u(t,x)=u(t,x)e^{u(t,x)^{2}}, \quad x\in \mathbf{R}^{2}, t>0, $$utt(t,x)−△u(t,x)=u(t,x)eu(t,x)2,x∈R2,t>0, is globally well-posed for small initial data, while for the combined nonlinearities
$$ u_{tt}(t,x)-\triangle u(t,x)=u(t,x) \bigl(e^{u(t,x)^{2}}+e^{u_{t}(t,x)^{2}} \bigr), \quad x \in \mathbf{R}^{2}, t>0 $$utt(t,x)−△u(t,x)=u(t,x)(eu(t,x)2+eut(t,x)2),x∈R2,t>0 with small initial data will blow up in finite time. Moreover, we obtain the lifespan results for the above problems.
New model of May cooperative system with strong and weak cooperative partners
Authors: Lin Qifa , Lei Chaoquan , Luo Shuwen , Xue Yalong 
Published: March 2020

AbstractIn this paper, based on the model of Zhao, Qin, and Chen [Adv. Differ. Equ. 2018:172, 2018], we propose a new model of the May cooperative system with strong and weak cooperative partners. The model overcomes the drawback of the corresponding model of Zhao, Qin, and Chen. By using the differential inequality theory, a set of sufficient conditions that ensure the permanence of the system are obtained. By combining the differential inequality theory and the iterative method, a set of sufficient conditions that ensure the extinction of the weak partners and the attractivity of the strong partners and the other species is obtained. Numeric simulations show that too large transform rate will lead to more complicated fluctuation; however, the system is still permanent.