bluuebunny/crossref_metadata_2025_split huggingface dataset:
EV-101: A Phase I Study of Single-Agent Enfortumab Vedotin in Patients With Nectin-4–Positive Solid Tumors, Including Metastatic Urothelial Carcinoma
Authors: Rosenberg Jonathan , Sridhar Srikala S. , Zhang Jingsong , Smith David , Ruether Dean , Flaig Thomas W. , Baranda Joaquina , Lang Joshua , Plimack Elizabeth R. , Sangha Randeep , Heath Elisabeth I. , Merchan Jamie , Quinn David I. , Srinivas Sandy , Milowsky Matthew , Wu Chunzhang , Gartner Elaina M. , Zuo Peiying , Melhem-Bertrandt Amal , Petrylak Daniel P. 
Published: February 2020

PURPOSE To assess the safety/tolerability and antitumor activity of enfortumab vedotin (EV), a novel investigational antibody-drug conjugate that delivers the microtubule-disrupting agent, monomethyl auristatin E, to cells that express Nectin-4. METHODS EV-101 is a phase I dose escalation/expansion study that enrolled patients with Nectin-4–expressing solid tumors (eg, metastatic urothelial carcinoma [mUC]) who progressed on ≥ 1 prior chemotherapy regimen and/or programmed death-1 receptor/programmed death ligand-1 [PD-(L)1] inhibitor, including a cohort of patients with mUC who received prior anti–PD-(L)1 therapy. Patients received escalating doses of EV up to 1.25 mg/kg on days 1, 8, and 15 of every 28-day cycle. Primary objectives were evaluation of safety/tolerability and pharmacokinetics; antitumor activity was a secondary objective. RESULTS Enrolled patients with mUC (n = 155) were heavily pretreated, with 96% having prior platinum-based chemotherapy and 29% receiving ≥ 3 lines of prior treatment. Maximum tolerated dose of EV was not established; however, the recommended phase II dose was identified as 1.25 mg/kg. Rash, peripheral neuropathy, fatigue, alopecia, and nausea were the most common treatment-related adverse events (TRAEs); the most common TRAEs were grade 1-2 in severity. Among the 112 patients with mUC treated with single-agent EV 1.25 mg/kg, the investigator-assessed confirmed objective response rate (ORR) was 43%, and duration of response was 7.4 months. Median overall survival (OS) was 12.3 months, and the OS rate at 1 year was 51.8%. Similar ORR and estimated median OS were observed in patients ≥ 75 years of age with and without prior anti–PD-(L)1 treatment, liver metastases, or upper-tract disease. CONCLUSION Single-agent EV was generally well tolerated and provided clinically meaningful and durable responses in patients with mUC; survival data are encouraging. A pivotal phase II and a confirmatory phase III study are ongoing.
Dystopias in the Kingdom of Israel: Prophetic Narratives of Destruction in Recent Hebrew Literature
Authors: Hochberg Gil 
Published: February 2020

Abstract
This article is about a recent wave of literary dystopias published in Israel, most of which center on the soon-to-come destruction of the Jewish state. Notable among these are The Third (Ha-shlishi) by Yishai Sarid (2015), Mud (Tit) by Dror Burstein (2016), and Nuntia (Kfor) by Shimon Adaf (2010). These texts draw on biblical or Rabbinic Hebrew, Jewish sources, and Jewish historical events (specifically the destruction of the First and Second Temples), making them just as much about a dystopian past as they are about a dystopian future. They are, in other words, dystopias of a circular temporality: emerging from and moving toward (Jewish) dystopia. This recent wave of Israeli dystopian narratives is primarily preoccupied with the past and future of Judaism, the Jewish people, and Israel as a secular-yet-Jewish state. Most interesting, perhaps, is the complete absence of Palestinians from these texts and from this dystopic imagination. Despite their obvious presence in Israel’s current reality, Palestinians have no role whatsoever in these texts. We are dealing therefore with exclusively Jewish dystopias. Read against some of the dystopian white South African writings under Apartheid, the complete absence of Palestinians in the recently published Israeli dystopias, appears particularly disheartening. Neither partner nor enemy, Palestinians do not even share in a future nightmare with Israeli Jews. We are left with the following questions: Does writing a Jewish Israeli dystopia require eliminating Palestinians from the narrative? Is it possible (how is it possible?) to think of a Jewish (Israeli) future, present, and past without thinking about a Palestinian past, present, and future? Following the example of South African dystopias, this article concludes that for such literary and ethical concerns to be critically explored, Israel must first be (officially) recognized as an apartheid regime.
Pascal Quignard as Sinophile: Recreating Chinese Antiquity in Contemporary France
Authors: Li Xiaofan Amy 
Published: February 2020

AbstractThis article examines the question of reinventing Chinese antiquity in the works of the contemporary French writer Pascal Quignard. It focuses on three aspects of Quignard’s Chinese-inspired works: his rewriting of ancient Chinese texts, his views on the idea of language via classical Chinese language and thought, and his recreation of Chinese antiquity via a radical contemporization of the past. This examination demonstrates that Quignard poses important questions about cultural reception and appropriation, especially as regards the problematic relation between sinophilia, Orientalism, and the reception of antiquity. Finally, the article proposes a nuanced view of Quignard’s sinophilia that recognizes both its merits and drawbacks. It concludes by arguing that despite the pitfalls of cultural misunderstanding and misrepresentation, Quignard spells out the conceptual death of French Orientalism in his refusal to fetishize Chinese antiquity and attests to a tendency in contemporary French literature and thought to creatively recycle foreign cultures and revise one’s understanding through the other.
Arx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome
Authors: Siehr Meagan S. , Massey Cory A. , Noebels Jeffrey L. 
Published: February 2020

ABSTRACT
X-linked infantile spasms syndrome (ISSX) is a clinically devastating developmental epileptic encephalopathy with life-long impact. Arx(GCG)10+7, a mouse model of the most common triplet-repeat expansion mutation of ARX, exhibits neonatal spasms, electrographic phenotypes and abnormal migration of GABAergic interneuron subtypes. Neonatal presymptomatic treatment with 17β-estradiol (E2) in Arx(GCG)10+7 reduces spasms and modifies progression of epilepsy. Cortical pathology during this period, a crucial point for clinical intervention in ISSX, has largely been unexplored, and the pathogenic cellular defects that are targeted by early interventions are unknown. In the first postnatal week, we identified a transient wave of elevated apoptosis in Arx(GCG)10+7 mouse cortex that is non-Arx cell autonomous, since mutant Arx-immunoreactive (Arx+) cells are not preferentially impacted by cell death. NeuN+ (also known as Rbfox3) survival was also not impacted, suggesting a vulnerable subpopulation in the immature Arx(GCG)10+7 cortex. Inflammatory processes during this period might explain this transient elevation in apoptosis; however, transcriptomic and immunohistochemical profiling of several markers of inflammation revealed no innate immune activation in Arx(GCG)10+7 cortex. Neither neonatal E2 hormone therapy, nor ACTH(1-24), the frontline clinical therapy for ISSX, diminished the augmented apoptosis in Arx(GCG)10+7, but both rescued neocortical Arx+ cell density. Since early E2 treatment effectively prevents seizures in this model, enhanced apoptosis does not solely account for the seizure phenotype, but may contribute to other aberrant brain function in ISSX. However, since both hormone therapies, E2 and ACTH(1-24), elevate the density of cortical Arx+-interneurons, their early therapeutic role in other neurological disorders hallmarked by interneuronopathy should be explored.
This article has an associated First Person interview with the first author of the paper.
Improved global α optical model potentials at low energies
Authors: Demetriou P. 
Published: February 2020

Many nuclear astrophysics applications involve radiative α-particle captures, α decays and Qi-particle transfer reactions. Theoretical estimates of the corresponding reaction rates within the framework of the statistical model of Hauser-Feshbach remain highly uncertain due to the poor knowledge of the α-nucleus optical model potential, especially at low energies far below the Coulomb barrier. In the present paper we propose new global α-optical potentials that take into account the strong energy dependence and nuclear structure effects that characterize the alpha-nucleus interaction. The real part of the potential is calculated using a double-folding procedure over the M3KY effective nucleon-nucleon interaction. A Woods-Saxon potential is used for the imaginary potential where now a new parametrization is introduced to describe its energy dependence. Three potentials are developed, one with purely volume absorption, one with volume plus surface absorption, and finally, one where in addition to volume and surface absorption, the dispersive contributions obtained from the dispersive relation are included. The three potentials considered are able to reproduce the bulk of experimental data on (a,7), (α,η), (a,p) and (η,α) reactions as well as the existing elastic scattering data at energies of relevance to astrophysical applications. However, when considering reaction rates for nuclei in the experimentally unexplored mass region, deviations within a factor of 10 are found. These uncertainties are mainly due to the difficulty in constraining the diffuseness of the imaginary potential from analyses of existing experimental data
Root mean square radii of the Λ-particle orbits in hypernuclei using potentials of orthogonal shape in arelativistic treatment
Authors: Koutroulos C. G. , Papadopoulos G. J. 
Published: February 2020

The root mean square radii of the Λ-particle orbits in hypernuclei are calculated in the ground and first excited states using the Dirac equation with scalar and vector potentials of orthogonal shape. An exact analytic and also approximate expressions are derived for the root mean square ra-' dius of the Λ orbit in its ground state. It is shown that <r > 2 1/2 1/3 ' varies linearly with A ' for the higer mass hypers 1/2 ^ nuclei, Our results in the ground state are compared with the results of Rayet and also with those of Daskaloyannis et. al.
Lifetime Measurements at NCSR “Demokritos”
Authors: Ashley S. F. , Axiotis M. , Foteinou V. , Harrisopulos S. , Konstantinopoulos T. , Lagoyannis A. , Mertzimekis T. J. , Provatas G. 
Published: February 2020

Proof-of-principle inelastic proton scattering measurements have been performed at NCSR “Demokritos”. Excited states in 64Zn and 92Mo were populated using the (p,p'γ) reaction with E(p) = 7 MeV. The reaction γ rays were detected using four HPGe detectors at eight separate angles, with respect to the beam-axis. From Doppler-shift attenuation of the ∞ rays, lifetimes for eight excited states in 64Zn and for the Iπ = 2^+_2 and 2^+_3 states in 92Mo were deduced. The lifetimes measured in 92Mo are in good agreement with adopted values whereas the lifetimes measured in 64Zn are typically longer than the literature values. Development of the experimental set-up and potential novel physics cases where this reaction could be used are briefly discussed.
GEANT4/GATE Simulation Studies in the Emission Tomography
Authors: Zioga M. , Menis J. , Apostolopoulou S. , Maintas D. , Mikeli M. , Nikopoulou A. , Rapsomanikis A.-N. , Stiliaris E. 
Published: February 2020

Radiotracer imaging studies for a small field, high resolution ∞-Camera system and a clinical system for Positron Emission Tomography (PET) by means of GATE (GEANT4 Application for Tomographic Emission) simulations are presented in this work. In a validation phase, which preceded the main study, experimentally obtained results for planar images with the existing ∞-Camera system were directly compared to simulated data. A simple phantom structure, consisting of four parallel capillaries filled with 99mTc water solution, was imaged by the γ-Camera system for several phantom-collimator distances and the measured and Monte-Carlo calculated spatial projections were compared. The major objective of this validation study was the optimal description of the most important components, the hexagonal, parallel-hole Pb-collimator and the pixelated CsI scintillation crystal of the γ-imaging system in terms of GATE components. In the main study, a GATE simulation setup for this ∞-Camera detector is used and Monte-Carlo data are accumulated for simple geometrical phantoms with different monophotonic radiotracer energies and relative intensities. In parallel, a commercially available cylindrical shaped PET scanner ring, consisting of 32 sectors with 4 x 6 x 6 LSO scintillation crystals, has been constructed in the GATE environment. Simulation data are obtained for the most usual positron emitters (18F, 11C and 15O) and for several phantom geometries. The spatial resolution of both systems and their overall performance is presented and discussed in this study.
Updated solar neutrino fluxes with new heavy element abundances
Authors: Karathanou G. I. , Tsikoudi V. , Kosmas T. S. 
Published: February 2020

In the present work we carry out an extensive study of the solar structure and solar evolution through the use of the TYCHO 6.92 code, which includes a variety of programs and subroutines. In this code we incorporate the most updated microphysical parameters such as screening, recent experimental measurements of the astrophysical factors-S (LUNA), several updated, recently measured, heavy element abundances, etc., and created new models describing crucial phenomena of the solar structure and solar evolution. We used this code to calculate and update nuclear reaction rates, solar neutrino fluxes, solar quantities which characterize the internal solar structure such as temperature, pressure, density, luminosity, heavy element abundances (4He, 12C, 14N, 16O, etc.) as well as sound speed profile and depth of the convection zone.
Exploring the experiences of student midwives completing the newborn infant physical examination
Authors: Meegan Samantha , Martin Toni 
Published: February 2020

Background The newborn and infant physical examination (NIPE) is a screening programme now undertaken by specially trained midwives. It is increasingly a feature within pre-registration midwifery educational programmes. Objectives To explore the experiences of student midwives completing the theory and practice aspects of the NIPE within a pre-registration midwifery programme. Design A qualitative design was utilised to analyse data collected by semi-structured interviews. Method This study was conducted using interpretative phenomenological analysis (IPA). Findings Three superordinate themes were generated: learning by doing, mentorship and transition to qualification. The findings demonstrate the benefits of student midwife exposure to practical aspects of NIPE. Conclusions Findings indicate that standardisation is required with NIPE education and clinical practice. Preceptorship programmes must effectively prepare newly qualified midwives to undertake the NIPE role. Higher educational institutes must provide greater support to the midwives providing mentorship of student midwife NIPE practitioners. Further research should examine the maintenance of the NIPE role following qualification as a midwife.
Autonomy and its impact on midwifery practice
Authors: Zolkefli Zulfaa Humairaa Haji , Mumin Khadizah Haji Abdul , Idris Deeni Rudita 
Published: February 2020

Objective To explore the definition of autonomy, its significant features and impacts on midwifery practice. Method Combined keywords searched were performed on electronic databases: Scopus, Science Direct and Medline within EBSCOhost and Google Scholar. Data were extracted and analysed corresponding to the objectives of this review. Findings A total of eight studies (n=8) were included (one quantitative and seven qualitative). Autonomy is the central element in midwifery that is commonly linked with informed choices; decision-making and power to control over a situation. In order for a midwife to be autonomous, important attributes include knowledge and skills (being confident, and the ability to think critically). It was also found that infrastructure and culture at work impacts autonomy in midwifery practice. Conclusion Albeit a limited number of studies were included in the review, this review provides an important platform for understanding the principles and concepts that underpin autonomy in midwifery practice.
<p><strong>Two new species of the genus <em>Leptobium</em> Casey from western Anatolia, Turkey (Coleoptera: Staphylinidae: Paederinae)</strong></p>
Authors: ANLAŞ SİNAN , GUSAROV VLADIMIR I. 
Published: February 2020

Leptobium izmiricum sp. nov. (İzmir province) and Leptobium keskini sp. nov. (Balıkesir province) from western Anatolia, Turkey, are described, illustrated and distinguished from related congeners. A total of 18 species of the genus Leptobium are now known from Turkey, 13 of them are endemics. Key words: Coleoptera, Staphylinidae, Paederinae, Leptobium, new species, Turkey
Glocalization, bricolage and black metal: Towards a music-centric youth culture simultaneously exemplifying the global and the glocal
Authors: Hoffin Kevin 
Published: February 2020

Abstract
This article aims to show how youth subculture is mapped onto both ‘global’ and ‘glocal’ terms. The progression of the article is as follows: from a basic overview of youth subculture, black metal and current research, it then begins to slowly unpack; using familiar examples of globalization, in business and of culture. The article introduces how globalization and bricolage have intertwined to create ‘glocalization’, and how this new way to view global communities has pushed our current ideas of youth subculture towards evolution. The article hopes to encourage re-analysis in how we think of youth subculture; away from monolithic tribes towards more subtly nuanced groupings.
From The Wicker Man (1973) to Atlantean Kodex: Extreme music, alternative identities and the invention of paganism
Authors: Spracklen Karl 
Published: February 2020

Abstract
The German epic heavy/doom metal band Atlantean Kodex has written two concept albums based on the folklore and paganism of old Europe and the West: The Golden Bough and The White Goddess. The two albums owe their titles to two books that have influenced the rise of modern paganism, though they remain deeply problematical. In this article, I explore possibly the most important influence on Atlantean Kodex, which is also one of the most important influences on modern paganism: the 1973 horror film The Wicker Man. I discuss the ways in which the film uses the speculative folklore of Frazer and Graves to construct a set of invented traditions about paganism and its alternative, counter-Christian nature, which have made paganism appealing to extreme metal musicians and fans. In this discussion, I use examples from other metal bands and fans who have name-checked the themes and the traditions of the film. In discussing the folklore of the Wicker Man, I also explore the folk music used in the soundtrack, which has also contributed to the invention of modern paganism and extreme folk music. I conclude by suggesting that, although many pagans have adopted this extreme music and myth into their world-views, the myth of the Wicker Man is also used as a playful rejection of Christianity and its authority by those of a secular or humanist persuasion.
Risk for Colorectal Neoplasia in Patients With Helicobacter pylori Infection: A Systematic Review and Meta-analysis
Authors: Choi Da Sol , Seo Seung In , Shin Woon Geon , Park Chan Hyuk 
Published: February 2020

OBJECTIVES:

Helicobacter pylori may reportedly be associated with extragastric malignancy beyond gastric cancer. The present study aimed to evaluate the association between H. pylori infection and colorectal neoplasia through a systematic review and meta-analysis.

METHODS:
The literature search aimed to retrieve all relevant studies published up to September 2019 that examined the risk for colorectal neoplasia including colorectal adenoma, advanced adenoma, and cancer in patients with H. pylori infection. Meta-analysis was performed to calculate pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs). If publication bias was observed, the pooled OR was adjusted using the trim-and-fill method.

RESULTS:
Forty-eight studies including 171,045 patients were evaluated, of which 24, 8, and 31 reported H. pylori-associated risk for adenoma, advanced adenoma, and cancer, respectively. H. pylori infection was associated with a significantly higher risk for colorectal adenoma (pooled OR 1.49 [95% CI 1.37–1.62]). H. pylori infection was also associated with a higher risk for advanced colorectal adenoma (pooled OR 1.50 [95% CI 1.28–1.75]). The risk for colorectal cancer in patients with H. pylori infection was also identified (pooled OR 1.44 [95% 1.26–1.65]). Although publication bias was identified in the analysis for colorectal adenoma, the pooled estimate was not significantly changed after adjustment (pooled OR 1.39 [95% CI 1.27–1.52]).

DISCUSSION:
Although this meta-analysis based on the observational studies could not show causality, it demonstrated that colorectal adenoma, advanced adenoma, and cancer were all associated with H. pylori infection.
Mechanisms of Resistance to Targeted Therapies in Acute Myeloid Leukemia and Chronic Myeloid Leukemia
Authors: Smith Catherine C. , Shah Neil P. 
Published: February 2020

Overview: Small molecule kinase inhibitors of BCR-ABL in chronic myeloid leukemia (CML) and of FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) in acute myeloid leukemia (AML) have been successful at achieving remissions in these diseases as monotherapy, but these leukemias do not initially respond in a subset of patients (primary resistance) and they progress in an additional group of patients after an initial response (secondary resistance). Resistance to these agents can be divided into mechanisms that allow reactivation kinase activity and those that bypass reliance on oncogenic signaling mediated by the target kinase. Elucidation of clinical resistance mechanisms to targeted therapies for patients can provide important insights into disease pathogenesis and signaling.