bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC
Authors: Sun Chenggong , Cao Wenyu , Qiu Chunping , Li Chengcheng , Dongol Samina , Zhang Zhiwei , Dong Ruifen , Song Kun , Yang Xingsheng , Zhang Qing , Kong Beihua 
Published: January 2020

Abstract
Background
PARP inhibitors have been the most promising target drugs with widely proven benefits among ovarian cancer patients. Although platinum-response, HR-related genes, or HRD genomic scar detection are acceptably used in assessment of Olaparib response, there are still evident limitations in the present approaches. Therefore, we aim to investigate more accurate approaches to predict Olaparib sensitivity and effective synergistic treatment strategies.

Methods
We probed two databases (TCGA and Qilu Hospital) in order to quest novel miRNAs associated with platinum-sensitivity or HR-related genes. Cellular experiments in vitro or in vivo and PDX models were utilized to validate their role in tumor suppression and Olaparib sensitizing. Furthermore, HR gene mutation was analyzed through WES to explore the relation between HR gene mutation and Olaparib response.

Results
High miR-509-3 expression indicated better response to platinum and longer progression-free and overall survival in two independent ovarian cancer patient cohorts (high vs. low miR-509-3 expression; PFS: TCGA P < 0.05, Qilu P < 0.05; OS: TCGA P < 0.05, Qilu P < 0.01). MiR-509-3 could impair the proliferation, migration, and invasion ability but enhance the sensitivity to Olaparib of ovarian cancer cell in vitro and in vivo by directly targeting HMGA2 and RAD51. In two PDX cases (PDX1 and PDX9), miR-509-3 could significantly increase the sensitivity to Olaparib along with the decrease of RAD51 positive rate (mean tumor weight NC + Olaparib vs. miR-509 + Olaparib; PDX1 P < 0.05, PDX9 P < 0.05). Additionally, in PDX8, miR-509-3 treatment dramatically reversed the Olaparib insensitivity (P < 0.05) by downregulating RAD51 expression. RAD51 functional detection revealed that all Olaparib sensitive cases exhibited low RAD51 positive rate (lesser than 50%) in treated groups. Furthermore, among the four HR gene mutation patients, three harbored HR core gene mutation and were sensitive to Olaparib while the remaining one with non-HR core gene mutation did not respond well to Olaparib.

Conclusions
MiR-509-3 can sensitize ovarian cancer cells to Olaparib by impeding HR, which makes it a potential target in PARPi synergistic treatment. HR core gene analysis and RAD51 functional detection are prospectively feasible in prediction of PARPi response.
Rationale and design of the randomised Treatment of sleep apnoea Early After Myocardial infarction with Adaptive Servo-Ventilation trial (TEAM-ASV I)
Authors:   for the TEAM-ASV I Investigators, Fox Henrik , Hetzenecker Andrea , Stadler Stefan , Oldenburg Olaf , Hamer Okka W. , Zeman Florian , Bruch Leonhard , Seidel Mirko , Buchner Stefan , Arzt Michael 
Published: January 2020

Abstract
Aims
In acute myocardial infarction (AMI), impaired myocardial salvage and large infarct size result in residual heart failure, which is one of the most important predictors of morbidity and mortality after AMI. Sleep-disordered breathing (SDB) is associated with reduced myocardial salvage index (MSI) within the first 3 months after AMI. Adaptive servo-ventilation (ASV) can effectively treat both types of SDB (central and obstructive sleep apnoea). The Treatment of sleep apnoea Early After Myocardial infarction with Adaptive Servo-Ventilation trial (TEAM-ASV I) will investigate the effects of ASV therapy, added to percutaneous coronary intervention (PCI) and optimal medical management of AMI, on myocardial salvage after AMI.

Methods/design
TEAM ASV-I is a multicentre, randomised, parallel-group, open-label trial with blinded assessment of PCI outcomes. Patients with first AMI and successful PCI within 24 h after symptom onset and SDB (apnoea–hypopnoea index ≥ 15/h) will be randomised (1:1 ratio) to PCI and optimal medical therapy alone (control) or plus ASV (with stratification of randomisation by infarct location; left anterior descending (LAD) or no LAD lesion). The primary outcome is the MSI, assessed by cardiac magnetic resonance imaging. Key secondary outcomes are change of infarct size, left ventricular ejection fraction and B-type natriuretic peptide levels and disease-specific symptom burden at 12 weeks.

Conclusion
TEAM ASV-I will help to determine whether treatment of SDB with ASV in the acute phase after myocardial infarction contributes to more myocardial salvage and healing.

Trial registration
ClinicalTrials.gov, NCT02093377. Registered on March 21, 2014.
Modeling of Real Time Kinematics localization error for use in 5G networks
Authors: Hoffmann Marcin , Kryszkiewicz Paweł , Koudouridis Georgios P. 
Published: January 2020

AbstractIn 5G networks information about localization of a user equipment (UE) can be used not only for emergency calls or location-based services, but also for the network optimization applications, e.g., network management or dynamic spectrum access by using Radio Environment Maps (REM). However, some of these applications require much better localization accuracy than currently available in 4G systems. One promising localization method is Global Navigation Satellite System (GNSS)-based Real-Time Kinematics (RTK). While the signal received from satellites is the same as in traditional GNSS, a new reception method utilizing real-time data from a nearby reference station (e.g., 5G base station) results in cm-level positioning accuracy. The aim of this paper is to obtain a model of the RTK localization error for smartphone-grade GNSS antenna under open-sky conditions, that can be used in 5G network simulators. First, a tutorial-style overview of RTK positioning, and satellite orbits prediction is provided. Next, an RTK localization simulator is implemented utilizing GNSS satellites constellations. Results are investigated statistically to provide a simple, yet accurate RTK localization error framework, which is based on two Gauss-Markov process generators parametrized by visible satellites geometry, UE motion, and UE-satellite distance error variance.
The energy-efficient MDA-SMAC protocol for wireless sensor networks
Authors: Wang Ke , Zhao Xiaohu , Shi Yao , Xu Donghong , Li Ruoyu 
Published: January 2020

AbstractNodes in original S-MAC protocol just can visit the channel in the scheduling and listening stage. The working schema may result in data latency and high conflict. To solve those above problems, we split scheduling duty into multiple micro-duties. By using different micro-dispersed contention channel, the sensor nodes reduce the collision probability of the data. Aiming at detecting the fixed duty cycle in S-MAC protocol, on the basis of the micro-duty and buffer queue length, this paper presents an adaptive duty cycle and back-off algorithm. While using different back-off algorithm with different duty cycles, sensor node Fast-Binary Exponential Backoff and Conflict-Avoid-Binary exponential Backoff algorithm separated are applied to reduce data latency further reduce the conflict probability. Combining both of the improvements, we propose a modified S-MAC protocol. Comparing the performance of S-MAC protocol and Division-Multiple Access-Media Access Control (MDA-SMAC) protocol on the NS-2 simulation platform, the results show that MDA-SMAC protocol performs better in terms of energy consumption, latency, and effective throughput than S-MAC protocol
Using of PQWs for solving NFID in the complex plane
Authors: Erfanian M. , Zeidabadi H. , Parsamanesh M. 
Published: January 2020

AbstractWe approximate the solution of the nonlinear Fredholm integro-differential equation (NFID) in the complex plane by periodic quasi-wavelets (PQWs). This kind of wavelets possesses orthonormality properties, the numbers of terms in the decomposition and reconstruction formulas are strictly limited, and the localization is not emphasized. To the best of our knowledge, there are no numerical methods to obtain the solution of the NFID by PQWs. Here, we attempt to obtain the numerical solution of the NFID based on B-spline functions. Finally, the simulation results are shown for three examples.
Multi-actor approaches to implement cooperative strategies and value chains based on sustainability
Authors: Contini Caterina , Marotta Giuseppe , Torquati Biancamaria 
Published: January 2020

AbstractThis special issue ofAgricultural and Food Economicsconsists of four articles that were part of the scientific programme of the First SIDEA-SIEA Joint Conference, held in Bisceglie in September 2017. The conference afforded agricultural economists the opportunity to reflect on cooperative strategies to promote competitiveness of the agri-food supply chain, with a focus on environmental quality and social sustainability.The selected articles address these themes from different perspectives: those of firms, of consumers, and of policy makers, stressing that sustainability calls for the active participation of all of the actors. The case studies presented propose an effective interpretation of the strategies for value creation with respect to the challenges of climate change, food waste management, the development of marginal rural areas, and that of the fish sector.
PI3K inhibitors in thrombosis and cardiovascular disease
Authors: Durrant Tom N. , Hers Ingeborg 
Published: January 2020

AbstractPhosphoinositide 3‐kinases (PI3Ks) are lipid kinases that regulate important intracellular signalling and vesicle trafficking events via the generation of 3‐phosphoinositides. Comprising eight core isoforms across three classes, the PI3K family displays broad expression and function throughout mammalian tissues, and the (patho)physiological roles of these enzymes in the cardiovascular system present the PI3Ks as potential therapeutic targets in settings such as thrombosis, atherosclerosis and heart failure. This review will discuss the PI3K enzymes and their roles in cardiovascular physiology and disease, with a particular focus on platelet function and thrombosis. The current progress and future potential of targeting the PI3K enzymes for therapeutic benefit in cardiovascular disease will be considered, while the challenges of developing drugs against these master cellular regulators will be discussed.
Incidence and risk factors of tuberculosis among the elderly population in China: a prospective cohort study
Authors: Cheng Jun , Sun Yan-Ni , Zhang Can-You , Yu Yan-Ling , Tang Li-Hong , Peng Hong , Peng Ying , Yao Yu-Xia , Hou Shuang-Yi , Li Jian-Wei , Zhao Jin-Ming , Xia Lan , Xu Lin , Xia Yin-Yin , Zhao Fei , Wang Li-Xia , Zhang Hui 
Published: January 2020

Abstract
Background
China is facing challenges of the shifting presentation of tuberculosis (TB) from younger to elderly due to an ageing population, longer life expectancy and reactivation disease. However, the burden of elderly TB and influence factors are not yet clear. To fill the gap, we generated a cohort study to measure the magnitude of TB incidence and associated factors among the elderly population aged 65 years and above in China.

Methods
In this cohort established in 2013 through a prevalence survey conducted in selected sites, a total of 34 076 elderlies without TB were enrolled into two-year follow-up. We used both active and passive case findings to find out all TB patients among them. The person-year (PY) incidence rates for both bacteriologically positive TB and active TB were calculated. Cox proportional regression model was performed to test effect of risk factors, and the population attributable fraction (PAF) of each risk factor contributing to incident TB among elderlies was calculated.

Results
Over the two-year follow-up period, a total of 215 incident active TB were identified, 62 of which were bacteriologically positive. The incidence rates for active TB and bacteriologically positive TB were 481.8 per 100 000 PY (95% CI: 417.4–546.2 per 100 000 PY) and 138.9 per 100 000 PY (95% CI: 104.4–173.5 per 100 000 PY), respectively. Incident cases detected by active case finding were significantly higher (P < 0.001). Male, non-Han nationality, previously treated TB, ex/current smoker and body mass index (BMI) < 18.5 presented as independent predictors for developing TB disease. For developing bacteriologically positive TB, the biggest contribution was from self-reported ex or current smoker (18.06%). And, for developing active TB, the biggest contribution was from non-Han nationality (35.40%), followed by male (26.80%) and age at 75 years and above (10.85%).

Conclusions
Ageing population in China had a high TB incidence rate and risk to develop TB disease, implying that National TB Program (NTP) needs to prioritize for elderly. Active case finding should be applied capture more active TB cases among this particular population, especially for male, non-Han nationality, and those with identified risk factors.
Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness
Authors: Marutani Eizo , Ichinose Fumito 
Published: January 2020

AbstractHydrogen sulfide (H2S) has long been known as a toxic environmental hazard. Discovery of physiological roles of H2S as a neurotransmitter by Kimura and colleagues triggered an intensive research in the biological roles of H2S in the past decades. Manipulation of H2S levels by inhibiting H2S synthesis or administration of H2S-releasing molecules revealed beneficial as well as harmful effects of H2S. As a result, it is now established that H2S levels are tightly controlled and too much or too little H2S levels cause harm. Nonetheless, translation of sulfide-based therapy to clinical practice has been stymied due to the very low therapeutic index of sulfide and the incomplete understanding of endogenous sulfide metabolism. One potential strategy to circumvent this problem is to use a safe and stable sulfide metabolite that may mediate effects of H2S. Alternatively, endogenous sulfide levels may be controlled using specific sulfide scavengers. In this review article, the role of endogenous H2S production and catabolism will be briefly reviewed followed by an introduction of thiosulfate and H2S scavengers as novel pharmacological tools to control H2S-dependent signaling.
Role of phototherapy, BAX gene expression in hyperbilirubinemia development in full-term neonates
Authors: Afifi Mohamed farouk , Abdel Mohsen Abdel Hakeem , Abdel Naeem Emad , Abdel razic Marwa Ibrahem 
Published: January 2020

Abstract
Background
Phototherapy is the main therapeutic interference for neonatal hyperbilirubinemia used to escape an exchange transfusion and to decrease the risk of bilirubin-induced encephalopathy (kernikterus). Phototherapy has an oxidative effect on cell components and cell membranes by enhancing peroxidation of lipid and damage to DNA. Many genes function as apoptosis regulatory genes. Examples of these genes involve the BCL2 gene as an anti-apoptotic oncogene, and the BAX gene which is a promoter of apoptosis.
We aimed to evaluate the effect of phototherapy on expression of BAX and Bcl2 genes in hyperbilirubinemic full-term neonates.
Eighteen full-term neonates with indirect hyperbilirubinemia who received phototherapy for 24 h were enrolled as a study group and nine apparently healthy full-term neonates with a normal serum bilirubin level were included as a control group. Assessment of the anti-apoptotic effect(s) of BCL2 and the pro-apoptotic effect(s) of (Bax) genes was achieved by quantitative assay of their products (BCL2 and BAX proteins) by ELISA assay after phototherapy.

Results
Significant decrease in the bcl2 (p < 0.001) and increase in Bax protein (p < 0.001) serum levels after phototherapy in hyperbilirubinemic full-term neonates.

Conclusion
Hyperbilirubinemia has no apoptotic influence, while phototherapy induces apoptosis in the peripheral blood of hyperbilirubinemic full-term infants.
Nutritional ketosis as an intervention to relieve astrogliosis: Possible therapeutic applications in the treatment of neurodegenerative and neuroprogressive disorders
Authors: Morris Gerwyn , Maes Michael , Berk Michael , Carvalho André F. , Puri Basant K. 
Published: January 2020

AbstractNutritional ketosis, induced via either the classical ketogenic diet or the use of emulsified medium-chain triglycerides, is an established treatment for pharmaceutical resistant epilepsy in children and more recently in adults. In addition, the use of oral ketogenic compounds, fractionated coconut oil, very low carbohydrate intake, or ketone monoester supplementation has been reported to be potentially helpful in mild cognitive impairment, Parkinson’s disease, schizophrenia, bipolar disorder, and autistic spectrum disorder. In these and other neurodegenerative and neuroprogressive disorders, there are detrimental effects of oxidative stress, mitochondrial dysfunction, and neuroinflammation on neuronal function. However, they also adversely impact on neurone–glia interactions, disrupting the role of microglia and astrocytes in central nervous system (CNS) homeostasis. Astrocytes are the main site of CNS fatty acid oxidation; the resulting ketone bodies constitute an important source of oxidative fuel for neurones in an environment of glucose restriction. Importantly, the lactate shuttle between astrocytes and neurones is dependent on glycogenolysis and glycolysis, resulting from the fact that the astrocytic filopodia responsible for lactate release are too narrow to accommodate mitochondria. The entry into the CNS of ketone bodies and fatty acids, as a result of nutritional ketosis, has effects on the astrocytic glutamate–glutamine cycle, glutamate synthase activity, and on the function of vesicular glutamate transporters, EAAT, Na+, K+-ATPase, Kir4.1, aquaporin-4, Cx34 and KATPchannels, as well as on astrogliosis. These mechanisms are detailed and it is suggested that they would tend to mitigate the changes seen in many neurodegenerative and neuroprogressive disorders. Hence, it is hypothesized that nutritional ketosis may have therapeutic applications in such disorders.
Predictors of stigma in a sample of mental health professionals: Network and moderator analysis on gender, years of experience, personality traits, and levels of burnout
Authors: Solmi Marco , Granziol Umberto , Danieli Andrea , Frasson Alberto , Meneghetti Leonardo , Ferranti Roberta , Zordan Maria , Salvetti Beatrice , Conca Andreas , Salcuni Silvia , Zaninotto Leonardo 
Published: January 2020

AbstractBackground.Stigma is one of the most important barriers to help-seeking and to personal recovery for people suffering from mental disorders. Stigmatizing attitudes are present among mental health professionals with negative effects on the quality of health care.Methods.Network and moderator analysis were used to identify what path determines stigma, considering demographic and professional variables, personality traits, and burnout dimensions in a sample of mental health professionals (n = 318) from six Community Mental Health Services. The survey included the Attribution Questionnaire-9, the Maslach Burnout Inventory, and the Ten-Item Personality Inventory.Results.The personality trait of openness to new experiences resulted to determine lower levels of stigma. Burnout (personal accomplishment) interacted with emotional stability in predicting stigma, and specifically, for subjects with lower emotional stability lower levels of personal accomplishment were associated with higher levels of stigma.Conclusions.Some personality traits may be accompanied by better empathic and communication skills, and may have a protective role against stigma. Moreover, burnout can increase stigma, in particular in subjects with specific personality traits. Assessing personality and burnout levels could help in identifying mental health professionals at higher risk of developing stigma. Future studies should determine whether targeted interventions in mental health professionals at risk of developing stigma may be effective in stigma prevention.
Body shape in inpatients with severe anorexia nervosa
Authors: Marzola Enrica , Panero Matteo , Cavallo Fabio , Delsedime Nadia , Abbate-Daga Giovanni 
Published: January 2020

AbstractBackground.Anorexia nervosa (AN) is a severe mental disorder. Body shape disturbances are key in the development and maintenance of AN. Only few data are available on inpatients with life-threatening AN. Therefore, we aimed to investigate if body shape difficulties—with a focus on both body checking and avoidance—could improve during hospitalization in both subtypes of AN and to ascertain eventual associations between body shape concerns upon admission and clinical outcome.Methods.Upon hospital admission and end of treatment (EOT), 139 inpatients with AN completed Body Shape Questionnaire (BSQ), Body Checking Questionnaire (BCQ), and Body Image Avoidance Questionnaire (BIAQ) in addition to measures of eating and general psychopathology.Results.Patients with severe AN reported improved BSQ and BIAQ scores at EOT while BCQ did not significantly change. Diagnostic subtypes differed only in baseline BSQ scores and had an impact on the improvement in BSQ at EOT. Baseline BCQ was associated with patients’ clinical improvement at EOT, even after controlling for age, duration of illness, Body Mass Index, depression, and anxiety scores.Conclusions.Data on body shape concerns and their trajectory during hospitalization for severe AN are lacking; our findings provide support to the effectiveness of hospitalization in improving body shape concerns and body avoidance, but not body checking. Also, baseline body shape concerns (especially body checking) impacted on clinical improvement. Future research is needed to identify treatments that could further improve the therapeutic approach to severe patients of AN in the acute setting.
Giant Inflatable Colon Model Enhances Lebanese Community Knowledge and Intention for Colorectal Cancer Screening
Authors: Baassiri Amro , El-Harakeh Mohammad , Itani Abdulrahman , Nassar Farah J. , Safi Remi , Dassouki Zeina , Romani Maya , Zgheib Nathalie , Nasr Rihab 
Published: January 2020

PURPOSE To assess the knowledge and intention for colorectal cancer (CRC) screening within the Lebanese community before and after a guided tour through an inflatable colon model. METHODS The Cancer Prevention and Control Program, Naef K. Basile Cancer Institute at the American University of Beirut Medical Center in collaboration with AMALOUNA educational nongovernmental organization launched awareness campaigns during which a walk-through inflatable colon was displayed. Pre- and post-surveys related to the age of screening, risk factors, symptoms, and CRC prevention were collected anonymously before and after touring the inflatable colon to assess the effectiveness of this educational tool. RESULTS Compiled data collected from 782 participants revealed that older age and higher education were predictors of favorable CRC screening knowledge and behaviors before entering the inflatable colon. Interestingly, touring the inflatable colon model significantly improved participants’ awareness and knowledge about CRC. Most importantly, it increased their willingness for screening and social engagement and comfort discussing and promoting CRC screening. CONCLUSION Overall, these results indicate that the interactive colon is an effective educational tool that can make a positive impact by improving the community CRC awareness and interest in CRC screening. They also highlight the importance of such educational efforts conducted in the community to create more awareness about CRC and emphasize the importance of its prevention.