bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurological presentation of COVID-19: experience from a tertiary care hospital of Bangladesh
Authors: Islam Md Rashedul , Rahman Tanbin , Ahmed Syed Mohaimeen , Khan Mohammad Sakhawat Hossen , Azad Md Rihan , Alam Dilruba , Habib Rumana 
Published: December 2020

Background: Neurological manifestations of COVID-19 are being recognized day by day although predominant presentation is of respiratory illness. Understanding of impact of the virus on nervous system is important for selection and evolution of treatment now and in the future. The aim of the study was to describe the manifestations of COVID-19 affecting nervous system in a tertiary care hospital of Bangladesh
Methods: This cross-sectional study was carried out in Department of Neurology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital from March, 2020 to October, 2020. Total forty patients who were admitted under neurology department were included in the study. Evidence of SARS-CoV-2 infection was confirmed in all the patients if RT-PCR of respiratory samples (eg, nasal or throat swab) was positive for viral ribonucleic acid (RNA). Clinical syndromes associated with COVID-19 were classified broadly as a cerebrovascular event, altered mental status and peripheral nervous system disorders. Data were collected on the basis of specific clinical case definitions.
Results: Median age of the patients was 58.6 years (range 22–73). Among those, 26 (65%) were male and 14 (35%) were female. Twenty two (55%) of 40 patients presented with cerebrovascular event, of whom 15 (68%) had an ischaemic stroke, 5 (23%) an intracerebral haemorrhage. Two (9%) patients were diagnosed as cerebral venous sinus thrombosis on the basis of clinical presentation and magnetic resonance venography (MRV) finding. Apart from cerebrovascular events, 14 (35%) of 40 patients presented with altered mental status, comprising 9 (64%) patients with unspecified encephalopathy and 5 (36%) patients with encephalitis. Four (10%) patients were diagnosed as peripheral nervous system disorder among those 2 (50%) as Guillain-Barré syndrome (GBS) and 2 (50%) as Bell’s palsy. If we analyze the presenting features of the 40 patients, it is found that, 22 (55%) patients presented with headache, 20 (5%) with hemiparesis, 20 (50%) with speech problems, 19 (48%) with altered mental status, 10(25%) with facial asymmetry, 4 (10%) with seizure. Few percentages of patients presented with anosmia (10%), ageusia (5%) and quadriparesis (5%).
Conclusion: Neurological involvement in COVID-19 is one of the major focuses of neurologist now a day. We have found cerebrovascular disese, encephalopathy and peripheral nervous system disorder as presentation of COVID-19 in our study. Prompt recognition of cases and early initiation of therapy will hasten better outcome of the patients. Neurological complications can cause permanent disability that will cost large scale health and economic burden. Further nationwide study is needed to quantify the association and disease burden.
Birdem Med J 2020; 10, COVID Supplement: 33-40
Pattern of electrolytes in a cohort of critically ill COVID-19 patients
Authors: Sultana Rozina , Ahsan ASM Areef , Fatema Kaniz , Ahmed Fatema , Saha Debasish Kumar , Saha Madhurima , Nazneen Suraiya , Mahbub Naureen , Ashraf Ebnan 
Published: December 2020

Background: Coronavirus disease 2019 (COVID-19) is a potentially fatal disease with multisystem involvement. Several studies have reported various electrolyte abnormalities at admission in patients who progress to the severe form of COVID-19. This study evaluated the electrolyte pattern in confirmed and critically ill COVID-19 patients.
Methods: This cross sectional study was carried out in the department of critical care medicine of BIRDEM General Hospital, Dhaka, Bangladesh, from 1st July to 10th November, 2020. Total 70 RT-PCR positive, critically ill COVID-19 patients, were enrolled. Patients’ demographic profile, clinical features, admission electrolyte report, length of ICU stay and outcome were documented in case record forms.
Results: In this cohort, total 70 RT-PCR positive COVID-19 cases (male 41, female 29, mean age 62.9 ± 13.3years) were enrolled. Fifty eight (82.85%) patients had different electrolytes abnormalities including hyponatraemia (54, 77.1%), hypokalaemia (35, 50%), hypocalcaemia (20, 28.6%) and hypomagnesaemia (11,15.7%). Regarding clinical symptoms, 98.6% (n=69) had respiratory distress, 97.1% (n=68) had cough, 94.3% (n= 66) had history of fever and 10.0 % (n=7) presented with unconsciousness. Diabetes mellitus (DM) was the most common co morbidity (94.3%).Mean length of ICU stay were 6.4 ± 3.4 days, where 48.57% (n=34) survived and 51.42% (n=36) died. Among 36 death cases, 33 patient (91.7%) had hyponatraemia (p value=0.003), which was statistically significant.
Conclusion: In this study, we found that, hyponatraemia was the most predominant electrolyte abnormality. Among 36 death cases, around 92% had hyponatraemia. Like other studies, it showed that various electrolyte imbalances seem to have an impact on disease process. So, base line electrolyte assessment would be beneficial for evaluating the risk of severity of COVID-19. So, more study of electrolytes in COVID-19 cases with multi center approach is needed.
Birdem Med J 2020; 10, COVID Supplement: 46-50
Demographic and clinical profile with early outcome of critically ill COVID-19 patients admitted in an ICU of a tertiary care hospital in Dhaka, Bangladesh
Authors: Ahsan ASM Areef , Sultana Rozina , Fatema Kaniz , Ahmed Fatema , Saha Debasish Kumar , Saha Madhurima , Nazneen Suraiya , Jahan Israt 
Published: December 2020

Background: First outbreak of corona virus disease (COVID-19) started in Wuhan, China at December 2019 and since then, it spread globally but information about critically ill patients with COVID-19 is still limited. So, it is important to know the demographic profile and overall outcome of COVID-19 patients. We aimed to describe the clinic-demographic characteristics and outcome of critically ill COVID-19 patients admitted in our intensive care unit.
Methods: This prospective observational study was carried out in the intensive care unit of department of Critical Care Medicine of BIRDEM General Hospital, Dhaka, Bangladesh from 11th June to 31st October, 2020. Out of 382 suspected cases, 86 patients were found to be RT-PCR for COVID-19 positive and were included in this study. After admission in ICU, all patients were resuscitated according to ICU protocol. Length of ICU stay were recorded and patient outcomes were mentioned as survival (transferred or discharged) or death.
Results: A total of 86 patients (male 53, female 33, mean age 63.6 ± 12.8 years) with RT-PCR for COVID-19 positive were enrolled in this study. Regarding COVID related symptoms, Ninety six percent(83) had respiratory distress, 93.02 % (n=80) had cough, 84.9% (n=73) had history of fever,11.6 % (n=10) had loose motion and 7% (n=6), had anosmia. Diabetes mellitus (DM) was the most common co morbidity (91.9%).For improvement of oxygenation of COVID patient, we treated 7% of patients (n=6) by nasal Cannula, 24.4% (n=21) by Face Mask, 20.9% (n=18) by Non Rebreather Mask, 22.1% (n= 19) by High Flow Nasal Cannula (HFNC) and 25.6% (n= 22) by Mechanical Ventilation. Mean length of ICU stay were 6.9 ± 3.6 days and range of icu stay were 1-20 days. Among 86 COVID patient, 51.16% (n=44) were transferred to the isolation ward or discharged at home and 48.8% (n=42) were died.
Conclusion: This study showed the overall demographic and clinical features of critically ill COVID-19 patients, admitted in an icu of a tertiary care hospital. As it is a single centered study, we need more study with multi center approach to know the detail demographic profile and outcome of COVID-19 patients.
Birdem Med J 2020; 10, COVID Supplement: 51-55
Concurrent tuberculosis and COVID-19: reports of three cases
Authors: Podder Chinmay Saha , Chowdhury Nandini 
Published: December 2020

Coronavirus disease 2019 (COVID-19), the latest global pandemic is on the hunt and the incidence is sharply rising day by day. On the other hand, tuberculosis (TB) is the leading causes of death from infectious origin. Historically, coronaviral illness were reported with co-infection with TB; Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is not an exception. As both diseases have overlapping clinical features, sometimes it maybe very difficult to diagnose and long standing features of TB can easily be mistaken for post-acute COVID-19. This report emphasizes the importance of suspecting TB-COVID co-infection and its grave consequences.
Birdem Med J 2020; 10, COVID Supplement: 111-114
Successful outcome of a severe COVID-19 patient with multiple co-morbidities: a case report
Authors: Sakib Mohammad Nazmus 
Published: December 2020

Patients with severe form of corona virus disease 2019 (COVID-19) with multiple co-morbidities can be treated successfully. We report a case of COVID-19 pneumonia complicated by acute respiratory distress syndrome (ARDS), occurring in an elderly male patient with (co-morbid )diabetes mellitus, hypertension, chronic kidney disease and obstructive sleep apnea. This case is reported to emphasize that managing severe COVID-19 patient with multi-disciplinary approach, keeping in mind each of the co-morbidities, can result a fourable outcome.
Birdem Med J 2020; 10, COVID Supplement: 127-130
Modelo de Lotka - Volterra en la biomatemática Solución de sistema depredador-presa
Authors: Amaya Cedrón Luis Andrés 
Published: December 2020

En la investigación, el modelo presa-depredador, también conocido como el modelo Lotka-Volterra, ha sido un punto de partida para el desarrollo de nuevas técnicas y teorías matemáticas. El modelo presadepredador se ocupa de la interacción entre dos especies, donde una de ellas (presa) tiene abundante comida y la segunda especie (depredador) tiene suministro de alimentos exclusivamente a la población de presas. Donde se supone también que, durante el proceso, en un intervalo de tiempo t, el medio no debería cambiar favoreciendo a ninguna de las especies y que cualquier adaptación genética es lo suficientemente lenta (Figueiredo, 2014). En este trabajo haremos el análisis de problema clásico de Presa-depredador.
Resgate do conhecimento etnozooterápico da Comunidade Barra do Una (Peruíbe-SP)
Authors: Prado Djalma Osmanir Pereira do , Ramires Milena 
Published: December 2020

Os animais são um dos recursos mais importantes para a humanidade desde os tempos primitivos. O uso destes como itens medicinais pode ser chamado de etnozoologia, sendo essa uma atividade histórica e geograficamente difundida no mundo todo. Esta pesquisa teve como objetivo resgatar e descrever o conhecimento etnozooterápico da comunidade Barra do Una, uma comunidade tradicional da Cidade de Peruíbe-SP. Foram feitas pesquisas de campo com os moradores, e os dados foram coletados por meio de questões semiestruturadas abordando o assunto. Foram citados 13 animais pelos entrevistados, e de acordo com eles, esses eram capazes de curar até 19 tipos de doenças. Os resultados da pesquisa mostraram um rico conhecimento sobre recursos medicinais faunísticos da comunidade, e o quão importante esse conhecimento foi para eles. Essas descrições, sobre os recursos faunísticos medicinais são importantes, principalmente, àquelas comunidades que não façam mais o usos destes, como a da presente pesquisa, onde, além de fortalecer os laços culturais, também podem servir como fontes de estudos à diversas áreas de relação com a sabedoria tradicional, como exemplos: saúde pública, antropologia, educação ambiental e cultural, dentre outros usos.
Peran Pendamping Desa Dalam Mewujudkan Desa Mandiri
Authors: Irfan Irfan , M. tahir M. tahir 
Published: December 2020

Peran pendamping desa adalah mendampingi pemerintah desa dalam perencanaan, pelaksanaan dan pemantauanterhadap pembangunanDesadan pemberdayaanmasyarakatDesa dalam mewujudkan desa mandiri. Penelitian ini tujuannya untuk mendeskripsikan peran pendamping desa dalam mewujudkan desa mandiri. Penelitian ini merupakan penelitian deskriptif kualitatif dengan pendekatan studi riset, yakni mengungkap kejadian nyata dilapangan. Teknik pengumpulan data adalah observasi, wawncara dan dokumentasi. Responden penelitian adalah kepala Desa, pendamping Desa dan sekertaris Desa BPD, ketua Karang Taruna, ketua pemuda. Hasil penelitian dianalisis dengan display data, verifikasi data dan uji keabsahan data lalu kesimpulan. Hasil penelitian ini menunjukan bahwa 1. Peran pendamping Desa di Desa Karampi Kecamatan Langgudu Kabupaten Bima belum efektif karena pendamping Desa tidak melaksanakan fungsing secara terpadu dan bersama-sama dengan pemerintah Desa dalam membangun Desa mandiri, namun keberadaan pendamping Desa hanya sebagai tim survay, pengambilan data untuk kebutuhan pelaporannya, 2. Kendala pendamping Desa dalam melaksanakan peran dan fugsingnya adalah keberadaan jalanan yang dilalui dari Desa yang satu dengan desa yang lain cukup jauh dan jalanan yang dilalui cukup rusak, adanya rasa malas yang tinggiu, kesadaramn bekerja masih kurang, keterbatasan SDM, kedisiplinan kerja yang masih diabaikan, rendahnya tanggungjawab bekerja.
BEHAVIORAL REACTIONS AND COGNITIVE FUNCTIONS IN RATS WITH VASCULAR MODEL OF ALZHEIMER'S TYPE DEMENTIA AT THE DIFFERENT STAGES OF DISEASE BEFORE AND AFTER STEM CELL CORRECTION
Authors: Lukyanova Yevgeniya , Nikolaeva Olga , Pavlova Olena , Vasyleva Iryna , Naglov Olexander , Shchegelskaya Elena , Omelchenko Olena 
Published: December 2020

Background. The last researches offer to conduct the study of Alzheimer disease (AD) mechanisms using diverse experimental models. However, it was not investigated the behavioral and cognitive impairment in rats at the different stages of vascular model of dementia of Alzheimer’s type developed by us.
Subjects and methods. The experiment was performed on 32 male WAG rats weighing 180-250 g which were divided into 4 groups. Rats from group 1 and 3 were injected by aqueous solution of sodium nitrite at a dose of 50 mg/kg of body mass intraperitoneally during 14 and 28 days respectively. Groups 2 and 4 were received 500,000 mesenchymal stem cells in suspension intravenously against the background of experimental nitrite-induced AD. To estimate the behavioral reactions and cognitive functions the Open Field Test (OFT) and Passive Avoidance test (PAT) were used.
Results. In all experimental groups in most cases it was found the significant decrease in vertical and horizontal activity (p <0,05) and an increase in the number of defecation in the OFT. Rats from group 3 had the drop in locomotor, research and orientation activity. In the OFT and PAT in groups 2,4 it was observed an improvement in research activity and significant cognitive functions recovery (p=0,012) after stem cell correction.
Conclusions. It was found the progression of the protective inhibition and cognitive impairment during experiment. The stem cells introduction had positive effects on brain function recovery.
ANATOMICAL PREDICTIONS OF DEVELOPMENT OF RHINOSINUSITIS AND ITS COMPLICATIONS
Authors: Alekseeva Victoriia 
Published: December 2020

Background. The anatomical structure of the paranasal sinuses of a person predetermines the risk of development, diversity of presentation, possibility of complications and features of surgical treatment of rhinosinusitis. Objective: of our study was to determine the thickness and density of the walls of the maxillary and frontal sinuses, which are potentially dangerous in terms of the development of complications. Materials and methods: Our study involved 121 subjects without any ENT diseases, who underwent SCT examination due to the reasons that were not related to abnormalities of ENT organs. Thickness and density in the region of the lower (orbital) wall and posterior (cerebral) wall of the frontal sinus were calculated. Results and Discussion: The maximum density was characteristic of the lower wall of the frontal sinus under physiological conditions and appeared 107.96 ± 201.64 Hu, the minimum for the lower wall was -29.98 ± 208.54 Hu. The thickness of the bone tissue in the frontal sinus was 4.05 ± 2.04 mm. Conclusion: The minimum density and thickness of the lower and posterior walls of the frontal sinus and upper and lower walls of the maxillary sinus was established under physiological conditions. The density of the posterior wall was found to be 25.4% lower than the density of the lower wall, and the thickness 22.2% lower.
A Methodological Approach to Identifying the Optimal Market Behavior Strategy Based on Fuzzy Game Modeling
Authors: Vilkov V. B. , Plotnikov V. A. , Plotnikov P. V. , Chernykh A. K. 
Published: December 2020

The presented study models market behavior strategies for firms in real (“impure”) markets.Aim. The presented study aims to develop tools for optimizing (according to the criterion of profit maximization) the market behavior of firms based on the achievements of modern mathematics.Tasks. The authors describe theoretical approaches to modeling the behavior of firms; define the problem of modeling the market behavior of firms in the language of game theory; modify the game model by implementing elements of the theory of fuzzy logic and fuzzy sets; develop and test a methodological approach to identifying the optimal behavior of firms based on fuzzy game modeling.Methods. This study uses general methods of economic and mathematical modeling, provisions of neoclassical and institutional firm theory, tools of game theory and the theory of fuzzy logic and fuzzy sets.Results. The optimal market behavior strategy for firms selling the same product is determined. The implementation of this strategy focuses on maximizing profits with allowance for the imperfections of real markets. A rigorous solution to this problem is proposed, based on the provisions of game theory, theory of fuzzy sets and fuzzy logic. The developed methodological approach to identifying the optimal market behavior strategy based on fuzzy game modeling is illustrated by a meaningful example.Conclusions. The developed and tested methodological approach to identifying the optimal market behavior strategy based on fuzzy game modeling described in the article allows firms to search for optimal strategies with allowance for the imperfections of real markets. It can be used for theoretical modeling of the behavior of firms in an “impure” market, including in a mixed economy, where the government has a certain degree of planning and administrative influence on economic processes. The proposed approach can be recommended for use by the management of firms in the development and implementation of competitive strategies.
Sobre la exposición de algunos problemas de la historia no sólo de America
Authors: S. Alperovic Moisej 
Published: December 2020

Abstract/ short description
The article brings up the universal idea that interpretations of historical events change in the course of history. The examples presented here are related to Latin American and Soviet history. One of such examples is the Marxists reading of the the important historic figure Simon Bolivar. In the original writings of Karl Marx, Bolivar was regarded as a Bonaparte-like despot. Later Marxists revised this critical portrayal claiming that Marx was badly informed, and Bolivar's anti-colonialism can be understood as compatible with the principles of Marxism.
Short description written by Michal Gilewski
Prediksi Jumlah Kunjungan Wisatawan Mancanegara di Indonesia dengan Menggunakan Metode ARIMA Box-Jenkins dan Jaringan Syaraf Tiruan
Authors: Indrasetianingsih Artanti , Damayanti Ika 
Published: December 2020

Salah satu bidang yang banyak diperebutkan di era Masyarakat Ekonomi Asia (MEA) adalah bidang pariwisata. Indonesia sebagai bagian dari Negara-negara ASEAN (Association of South East Asian Nations), merupakan negara yang kaya akan budaya dan memiliki banyak destinasi wisata yang patut diperhitungkan baik di tingkat regional maupun internasional. Jumlah kunjungan wisatawan mancanegara (wisman) ke Indonesia mengalami peningkatan dari tahun ke tahun. Peningkatan jumlah kunjungan wisatawan mancanegara tersebut ternyata masih menempatkan Indonesia di posisi ke empat di negara-negara ASEAN pada tahun 2012 dan 2014. Pada tahun 2019, Kementrian Pariwisata (Kemenpar) menargetkan jumlah wisman yang berkunjung ke Indonesia sebesar 20 juta. Perlu adanya sinergi dari pemerintah dan masyarakat, baik dari pemerintah pusat maupun daerah. Selain itu juga diperlukan adanya perencanaan dan strategi promosi yang tepat. Salah satu cara untuk memperoleh gambaran tentang jumlah kunjungan wisatawan mancanegara ke Indonesia adalah melakukan peramalan dengan menggunakan analisis deret runtun waktu. Tujuan dari penelitian ini adalah untuk memperoleh prediksi jumlah wisatawan mancanegara yang berkunjung ke Indonesia tahun 2017 s.d tahun 2019 dengan menggunakan metode ARIMA Box-Jenkins dan Jaringan Syaraf Tiruan, serta membandingkan hasil prediksi jumlah kunjungan wisatawan mancanegara ke Indonesia hasil menggunakan ARIMA Box-Jenkins dengan Jaringan Syaraf Tiruan. Data yang digunakan adalah data bulanan jumlah kunjungan wisman ke Indonesia mulai bulan Januari 2010 sampai bulan Juni 2017. Hasil yang diperoleh dari analisis ARIMA Box Jenkins adalah model ARIMA (0,1,1)(0,0,2)12 , sedangkan hasil analisis menggunakan Jaringan Syaraf Tiruan algoritma backpropagation yang digunakan adalah dengan hidden layer 3. Hasil perhitungan nilai kesalahan peramalan dengan MAPE, MAD dan MSE didapatkan bahwa metode ARIMA mempunyai nilai MAD = 8.069,81 dan MSE = 9.134.981.806,98 yang lebih rendah dibanding metode Jaringan Syaraf Tiruan, maka metode yang lebih baik digunakan untuk meramalkan jumlah kunjungan wisman ke Indonesia adalah ARIMA (0,1,1)(0,0,2)12.
KETEPATAN KLASIFIKASI STATUS DIABETES MELITUS DENGAN PENDEKATAN MULTIVARIATE ADAPTIVE REGRESSION SPLINE
Authors: Jusuf Herlina , Otok Bambang widjanarko , Ningrum Amanda ratna 
Published: December 2020

Diabetes Mellitusadalah suatu penyakit gangguan metabolik akut yang ditandai oleh kadar glukosa darah melebihi nilai normal. Diabetes Mellitus merupakan suatu penyakit atau kelainan yang mempengaruhi kemampuan tubuh untuk mengubah makanan menjadi energy. Dengan semakin meningkatnya prevalensi kasus penyakit Diabetes Mellitus, maka tujuan penelitian ini adalah memprediksi variabel apa saja yang berperan sangat besar sebagai salah satu faktor risiko kejadian Diabetes Mellitus. Hasil penelitian menunjukkan bahwa status diabetes mellitus terdapat hubungannya dengan obesitas, hipertensi dan kebiasaan olahraga, sedangkan dengan pendekatan MARS melalui criteria GCV terkecil dan (R-O)2 terbesar diperoleh factor yang mempengaruhi status diabetes mellitus adalah obesitas dan hipertensi dengan ketepatan klasifikasi sebesar 74.0 persen.
Kata kunci : Diabetes Mellitus, Obesitas, Hipertensi,MARS
Fair value: characteristics and impact on economic security
Authors: Kozmenkova Svetlana 
Published: December 2020

The article examines the concept of “fair value” when applying international and national financial reporting standards, including public sector organizations. And although the assessment at fair value is used only
in certain cases, for example, when receiving property free of charge, drawing up reports in accordance with the requirements of international standards, and this is justified, however, the subsequent assessment of assets can
be subjective and have a significant impact on economic security, as a separate organization and the country as a whole.