bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Performance of the Node Control Volume Finite Element Method for Modeling Multi-phase Fluid Flow in Heterogeneous Porous Media
Authors: Abd Abdul Salam , Abushaikha Ahmad S. 
Published: September 2020

AbstractIn this paper, we critique the performance of the node control volume finite element (NCVFE) method for modeling multi-phase fluid flow in heterogeneous media. The NCVFE method solves for the pressure at the vertices of elements and a control volume mesh is constructed around them. Material properties are defined on elements, while transport is simulated on the control volumes. These two meshes are not aligned producing inaccurate results and artificial fluid smearing when modeling multi-phase fluid flow in heterogeneous media. We perform numerical tests to quantify and visualize the extent of this artificial fluid smearing in domains with different material properties. The domains are composed of tetrahedron finite elements. Large artificial fluid smearing is observed in coarse meshes; however, it decreases with the increase in mesh resolution. These findings prompt the use of high-resolution meshes for the method and the need for development of novel numerical methods to address this unphysical flow.
Benchmarking the Robustness of Semantic Segmentation Models with Respect to Common Corruptions
Authors: Kamann Christoph , Rother Carsten 
Published: September 2020

AbstractWhen designing a semantic segmentation model for a real-world application, such as autonomous driving, it is crucial to understand the robustness of the network with respect to a wide range of image corruptions. While there are recent robustness studies for full-image classification, we are the first to present an exhaustive study for semantic segmentation, based on many established neural network architectures. We utilize almost 400,000 images generated from the Cityscapes dataset, PASCAL VOC 2012, and ADE20K. Based on the benchmark study, we gain several new insights. Firstly, many networks perform well with respect to real-world image corruptions, such as a realistic PSF blur. Secondly, some architecture properties significantly affect robustness, such as a Dense Prediction Cell, designed to maximize performance on clean data only. Thirdly, the generalization capability of semantic segmentation models depends strongly on the type of image corruption. Models generalize well for image noise and image blur, however, not with respect to digitally corrupted data or weather corruptions.
Age-dependent modulation of bone metabolism in zebrafish scales as new model of male osteoporosis in lower vertebrates
Authors: Carnovali Marta , Banfi Giuseppe , Mariotti Massimo 
Published: September 2020

AbstractAfter middle age, in human bone, the resorption usually exceeds formation resulting in bone loss and increased risk of fractures in the aged population. Only few in vivo models in higher vertebrates are available for pathogenic and therapeutic studies about bone aging. Among these, male Danio rerio (zebrafish) can be successfully used as low vertebrate model to study degenerative alterations that affect the skeleton during aging, reducing the role of sex hormones.In this paper, we investigated the early bone aging mechanisms in male zebrafish (3, 6, 9 months old) scales evaluating the physiological changes and the effects of prednisolone, a pro-osteoporotic drug.The results evidentiated an age-dependent reduction of the mineralization rate in the fish scales, as highlighted by growing circle measurements. Indeed, the osteoblastic ALP activity at the matrix deposition site was found progressively downregulated.The higher TRAP activity was found in 63% of 9-month-old fish scales associated with resorption lacunae along the scale border. Gene expression analysis evidentiated that an increase of the tnfrsf1b (homolog of human rank) in aging scales may be responsible for resorption stimulation.Interestingly, prednisolone inhibited the physiological growth of the scale and induced in aged scales a more significant bone resorption compared with untreated fish (3.8% vs 1.02%). Bone markers analysis shown a significant reduction of ALP/TRAP ratio due to a prednisolone-dependent stimulation of tnfsf11 (homolog of human rankl) in scales of older fish.The results evidentiated for the first time the presence of a senile male osteoporosis in lower vertebrate. This new model could be helpful to identify the early mechanisms of bone aging and new therapeutic strategies to prevent age-related bone alterations in humans.
Training general practitioners to improve evidence-based drug treatment of patients with heart failure: a cluster randomised controlled trial
Authors: Valk M. J. M. , Hoes A. W. , Mosterd A. , Landman M. A. , Zuithoff N. P. A. , Broekhuizen B. D. L. , Rutten F. H. 
Published: September 2020

Abstract
Aims
To assess whether a single training session for general practitioners (GPs) improves the evidence-based drug treatment of heart failure (HF) patients, especially of those with HF with reduced ejection fraction (HFrEF).

Methods and results
A cluster randomised controlled trial was performed for which patients with established HF were eligible. Primary care practices (PCPs) were randomised to care-as-usual or to the intervention group in which GPs received a half-day training session on HF management. Changes in HF medication, health status, hospitalisation and survival were compared between the two groups. Fifteen PCPs with 200 HF patients were randomised to the intervention group and 15 PCPs with 198 HF patients to the control group. Mean age was 76.9 (SD 10.8) years; 52.5% were female. On average, the patients had been diagnosed with HF 3.0 (SD 3.0) years previously. In total, 204 had HFrEF and 194 HF with preserved ejection fraction (HFpEF). In participants with HFrEF, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers decreased in 6 months in both groups [5.2%; (95% confidence interval (CI) 2.0–10.0)] and 5.6% (95% CI 2.8–13.4)], respectively [baseline-corrected odds ratio (OR) 1.07 (95% CI 0.55–2.08)], while beta-blocker use increased in both groups by 5.2% (95% CI 2.0–10.0) and 1.1% (95% CI 0.2–6.3), respectively [baseline-corrected OR 0.82 (95% CI 0.42–1.61)]. For health status, hospitalisations or survival after 12–28 months there were no significant differences between the two groups, also not when separately analysed for HFrEF and HFpEF.

Conclusion
A half-day training session for GPs does not improve drug treatment of HF in patients with established HF.
Bandwidth-tunable optical filter based on microring resonator and MZI with Fano resonance
Authors: Li Xia , Shen Chen , Yu Xiaohan , Zhang Yanqiong , Chen Chao , Zhang Xiaoxu 
Published: September 2020

AbstractA bandwidth-tunable optical filter is fabricated by combining Mach–Zehnder interferometer (MZI) and microring resonator. Both bandwidth red-shift and blue-shift are observed in the experiment. The bandwidth can be tuned from 0.46 to 3.09 nm by controlling two phase shifters. The device also shows an extinction ratio higher than 25 dB. Potential applications are integrated optical signal processing such as reconfigurable filtering and channel selecting in wavelength division multiplexer.
The Entrepreneurial University: How to Develop the Entrepreneurial Orientation of Academia
Authors: Feola Rosangela , Parente Roberto , Cucino Valentina 
Published: September 2020

AbstractIn the last years, universities have assumed a prominent role in the science and technology-based economic development. The concept of entrepreneurial university, a key concept in the triple helix model developed by Etzkowitz, identifies the evolution of the university role with the addition to the traditional missions of university (education and research) of a third mission that is to contribute to the economic development through the transfer of research results from the laboratory to the economic system. The objective of the research is to analyze how universities are implementing this new mission and investigate factors affecting their entrepreneurial orientation. More specifically, our paper aims to investigate the existence of a relationship among the entrepreneurial orientation of university and some factors representing the internal and external context in which the university is involved.
Host Mitochondrial Requirements of Cytomegalovirus Replication
Authors: Monk Chandler H. , Zwezdaryk Kevin J. 
Published: September 2020

Abstract
Purpose of Review
Metabolic rewiring of the host cell is required for optimal viral replication. Human cytomegalovirus (HCMV) has been observed to manipulate numerous mitochondrial functions. In this review, we describe the strategies and targets HCMV uses to control different aspects of mitochondrial function.

Recent Findings
The mitochondria are instrumental in meeting the biosynthetic and bioenergetic needs of HCMV replication. This is achieved through altered metabolism and signaling pathways. Morphological changes mediated through biogenesis and fission/fusion dynamics contribute to strategies to avoid cell death, overcome oxidative stress, and maximize the biosynthetic and bioenergetic outputs of mitochondria.

Summary
Emerging data suggests that cytomegalovirus relies on intact, functional host mitochondria for optimal replication. HCMV large size and slow replication kinetics create a dependency on mitochondria during replication. Targeting the host mitochondria is an attractive antiviral target.
The Materiality of Odors: Experiencing Church Burials and the Urban Environment in Early Modern Northern Sweden
Authors: Kallio-Seppä Titta , Tranberg Annemari 
Published: September 2020

AbstractArchaeological material from early modern Sweden reveals that material and social meaning was intertwined in townscape odors; that is, odors and their association with unhygienic conditions affected the physical structure of the town, its material culture, and different traditions in the use of “townspace.” During the latter half of the 18th century, the town of Oulu suffered from unpleasant smells related to ponds and wet areas, and the odor of decomposing flesh from under-floor church burials greeted church visitors, despite the tradition of placing fragrant plants inside coffins. In the 18th century the town underwent deliberate changes: the ponds were drained and filled, burials under the church floor were prohibited, and one of the first graveyards located outside the town and separate from the church was constructed. These actions to change the town’s “smellscape” reflect emergent notions of regularity and cleanliness related to the Age of Enlightenment.
Sexual Dysfunction Among Young Adults in Sweden—A Population-Based Observational Study
Authors: Ljungman Lisa , Lampic Claudia , Wettergren Lena 
Published: September 2020

Abstract

Introduction
There is a lack of studies using validated instruments to investigate prevalence and predictors of sexual dysfunction among young adults.

Aim
This population-based observational study aimed to determine the prevalence and predictors of sexual dysfunction in young adults in Sweden and to compare sexual function in women and men.

Methods
A random sample of the general population aged 19-40 years, identified via the Swedish population registry, was approached with a postal survey. A total of 819 individuals participated, 493 women (51% response) and 326 men (34% response). Predictors of sexual dysfunction were identified by multivariable logistic binary regression analyses.

Main outcome measure
Sexual function and satisfaction were assessed using the Patient-Reported Outcomes Measurement Information System Sexual Function and Satisfaction measure, version 2.0.

Results
Among the women, 53% reported at least one sexual dysfunction; the corresponding figure for men was 31%. The most common sexual dysfunction in women was low sexual interest (reported by 32%), whereas low satisfaction with sex life was the most common dysfunction in men (reported by 17%). Men reported a higher level of sexual interest and orgasm ability than women, whereas women reported a higher level of orgasm pleasure than men. Regression models showed that in both women and men, having a partner was related to lower risk of dysfunction in the domains satisfaction with sex life and orgasm pleasure. Having children was related to low interest in sex in women, whereas it was related to dissatisfaction with sex life in men. Being born outside of Sweden predicted sexual dysfunction in both women and men, as did experiencing symptoms of anxiety and depression.

Conclusion
Sexual dysfunction is common in young adults, particularly in women. Risk factors of sexual dysfunction include not having a partner, having children, being an immigrant, and reporting symptoms of anxiety and depression.
Use of viral DNA surrogate markers to study routes of transmission of healthcare-associated pathogens
Authors: Thakur Manish , Alhmidi Heba , Cadnum Jennifer L. , Jencson Annette L. , Bingham Jessica , Wilson Brigid M. , Donskey Curtis J. 
Published: September 2020

AbstractBackground:The hands of healthcare personnel are the most important source for transmission of healthcare-associated pathogens. The role of contaminated fomites such as portable equipment, stethoscopes, and clothing of personnel in pathogen transmission is unclear.Objective:To study routes of transmission of cauliflower mosaic virus DNA markers from 31 source patients and from environmental surfaces in their rooms.Design:A 3-month observational cohort study.Setting:A Veterans’ Affairs hospital.Methods:After providing care for source patients, healthcare personnel were observed during interactions with subsequent patients. Putative routes of transmission were identified based on recovery of DNA markers from sites of contact with the patient or environment. To assess plausibility of fomite-mediated transmission, we assessed the frequency of transfer of methicillin-resistant Staphylococcus aureus (MRSA) from the skin of 25 colonized patients via gloved hands versus fomites.Results:Of 145 interactions involving contact with patients and/or the environment, 41 (28.3%) resulted in transfer of 1 or both DNA markers to the patient and/or the environment. The DNA marker applied to patients’ skin and clothing was transferred most frequently by stethoscopes, hands, and portable equipment, whereas the marker applied to environmental surfaces was transferred only by hands and clothing. The percentages of MRSA transfer from the skin of colonized patients via gloved hands, stethoscope diaphragms, and clothing were 52%, 40%, and 48%, respectively.Conclusions:Fomites such as stethoscopes, clothing, and portable equipment may be underappreciated sources of pathogen transmission. Simple interventions such as decontamination of fomites between patients could reduce the risk for transmission.
Identification of prosthetic hip and knee joint infections using administrative databases—A validation study
Authors: Kandel Christopher E. , Jenkinson Richard , Widdifield Jessica , Hansen Bettina E. , Davey J. Roderick , Muller Matthew P. , Daneman Nick , McGeer Allison 
Published: September 2020

AbstractObjective:To determine whether combinations of diagnosis and procedures codes can improve the detection of prosthetic hip and knee joint infections from administrative databases.Design:We performed a validation study of all readmissions from January 1, 2010, until December 31, 2016, following primary arthroplasty comparing the diagnosis and procedure codes obtained from an administrative database based upon the International Classification of Disease, Tenth Revision (ICD-10) to the reference standard of chart review.Setting:Four tertiary-care hospitals in Toronto, Canada, from 2010 to 2016.Participants:Individuals who had a primary arthroplasty were identified using procedure codes.Intervention:Chart review of readmissions identified the presence of a prosthetic joint infection and, if present, the surgical procedure performed.Results:Overall, 27,802 primary arthroplasties were performed. Among 8,844 readmissions over a median follow-up of 669 days (interquartile range, 256–1,249 days), a PJI was responsible for or present in 586 of 8,844 (6.6%). Diagnosis codes alone exhibited a sensitivity of 0.88 (95% CI, 0.85–0.92) and positive predictive value (PPV) of 0.78 (95% CI, 0.74–0.82) for detecting a PJI. Combining a PJI diagnosis code with procedure codes for an arthroplasty and the insertion of a peripherally inserted central catheter improved detection: sensitivity was 0.92 (95% CI, 0.88–0.94) and PPV was 0.78 (95% CI, 0.74–0.82). However, procedure codes were unable to identify the specific surgical approach to PJI treatment.Conclusions:Compared to PJI diagnosis codes, combinations of diagnosis and procedure codes improve the detection of a PJI in administrative databases.
Hepatoblastoma diagnosed in infancy occurring in single-ventricle patients: a case series
Authors: Windom McAllister O. , Campbell M. Jay 
Published: September 2020

AbstractHepatoblastoma is the most common primary liver tumour in children; however, there are no reported incidences in the single-ventricle congenital heart disease population. We present three cases in patients with single-ventricle heart disease with a mean age at diagnosis of 19.7 (±4) months. The diagnosis was made prior to Fontan completion in all three cases. These represent the only documented hepatoblastoma cases in single-ventricle patients.
Effectiveness of a housing support team intervention with a recovery-oriented approach on hospital and emergency department use by homeless people with severe mental illness: a randomised controlled trial
Authors: Tinland A. , Loubière S. , Boucekine M. , Boyer L. , Fond G. , Girard V. , Auquier P. 
Published: September 2020

AbstractAimsMany people who are homeless with severe mental illnesses are high users of healthcare services and social services, without reducing widen health inequalities in this vulnerable population. This study aimed to determine whether independent housing with mental health support teams with a recovery-oriented approach (Housing First (HF) program) for people who are homeless with severe mental disorders improves hospital and emergency department use.MethodsWe did a randomised controlled trial in four French cities: Lille, Marseille, Paris and Toulouse. Participants were eligible if they were 18 years or older, being absolutely homeless or precariously housed, with a diagnosis of schizophrenia (SCZ) or bipolar disorder (BD) and were required to have a high level of needs (moderate-to-severe disability and past hospitalisations over the last 5 years or comorbid alcohol or substance use disorder). Participants were randomly assigned (1:1) to immediate access to independent housing and support from the Assertive Community Treatment team (social worker, nurse, doctor, psychiatrist and peer worker) (HF group) or treatment as usual (TAU group) namely pre-existing dedicated homeless-targeted programs and services. Participants and interviewers were unmasked to assignment. The primary outcomes were the number of emergency department (ED) visits, hospitalisation admissions and inpatient days at 24 months. Secondary outcomes were recovery (Recovery Assessment Scale), quality of life (SQOL and SF36), mental health symptoms, addiction issues, stably housed days and cost savings from a societal perspective. Intention-to-treat analysis was performed.ResultsEligible patients were randomly assigned to the HF group (n= 353) or TAU group (n= 350). No differences were found in the number of hospital admissions (relative risk (95% CI), 0.96 (0.76–1.21)) or ED visits (0.89 (0.66–1.21)). Significantly less inpatient days were found for HFv.TAU (0.62 (0.48–0.80)). The HF group exhibited higher housing stability (difference in slope, 116 (103–128)) and higher scores for sub-dimensions of S-QOL scale (psychological well-being and autonomy). No differences were found for physical composite score SF36, mental health symptoms and rates of alcohol or substance dependence. Mean difference in costs was €-217 per patient over 24 months in favour of the HF group. HF was associated with cost savings in healthcare costs (RR 0.62(0.48–0.78)) and residential costs (0.07 (0.05–0.11)).ConclusionAn immediate access to independent housing and support from a mental health team resulted in decreased inpatient days, higher housing stability and cost savings in homeless persons with SCZ or BP disorders.
Geophysical Observations of Phobos Transits by InSight
Authors: Stähler S. C. , Widmer‐Schnidrig R. , Scholz J.‐R. , van Driel M. , Mittelholz A. , Hurst K. , Johnson C. L. , Lemmon M. T. , Lognonné P. , Lorenz R. D. , Müller N. T. , Pou L. , Spiga A. , Banfield D. , Ceylan S. , Charalambous C. , Clinton J. , Giardini D. , Nimmo F. , Panning M. , Zürn W. , Banerdt W. B. 
Published: September 2020

AbstractSince landing on Mars, the NASA InSight lander has witnessed eight Phobos and one Deimos transits. All transits could be observed by a drop in the solar array current and the surface temperature, but more surprisingly, for several ones, a clear signature was recorded with the seismic sensors and the magnetometer. We present a preliminary interpretation of the seismometer data as temperature‐induced local deformation of the ground, supported by terrestrial analog experiments and finite‐element modeling. The magnetic signature is most likely induced by changing currents from the solar arrays. While the observations are not fully understood yet, the recording of transit‐related phenomena with high sampling rate will allow more precise measurements of the transit times, thus providing additional constraints for the orbital parameters of Phobos. The response of the seismometer can potentially also be used to constrain the thermoelastic properties of the shallow regolith at the landing site.
Regional and Sectoral Sources for Black Carbon Over South China in Spring and Their Sensitivity to East Asian Summer Monsoon Onset
Authors: Fang Chenwei , Zhu Bin , Pan Chen , Yun Xiao , Ding Deping , Tao Shu 
Published: September 2020

AbstractBesides local emissions, biomass burning (BB) emissions in peninsula Southeast Asia (PSEA) and domestic anthropogenic emissions in North China (NC) are also significant black carbon (BC) sources over South China (SC) in spring. Meanwhile, the East Asian summer monsoon (EASM) is established with the wind field reversal, influencing the region‐based contributions to BC over SC. Herein, BC sources for SC were tracked by region and by sector using the Community Earth System Model with a BC‐tagging technique. During the spring of 2000–2014, 27% of BC surface concentration (BCS) and 64% of BC column burden (BCC) over SC stems from nonlocal sources. BC from NC is mainly transported below 850 hPa. It is the dominant nonlocal contribution to BCS (17%) and largely composed of residential and industrial sectors. Nonlocal emissions inside and outside China contribute 28% and 36% to BCC, respectively. Generally transported above 850 hPa, BC from PSEA is the largest nonlocal contributor (20%) to BCC and contributes 80% of BCC in BB sector. Additionally, the interannual variation in EASM onset times bring a maximum of −5% to +7%/−2% to +7% variation in BCC/BCS. The BC outflow/inflow contributed from NC dominates the BC decrease/increase over SC with southerly/northerly wind anomaly induced by early/late EASM onset, yet regional transport from PSEA contributes minor BC changes. The simulated BC is significantly positively correlated with the varying EASM onset times, but not with emissions, indicating the decisive role of meteorology in the interannual variation of BC over SC during springtime.