bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a Breastfeeding Program for Mothers Returning to Work in Japan: a quasi-experiment study
Authors: Nakada Kaori 
Published: June 2020

Abstract
Background: Maternal employment has been described as a barrier to breastfeeding in many countries. In Japan, many mothers quit breastfeeding after returning to work because they do not know how to continue breastfeeding. The primary objective of this study was to investigate the effectiveness of a breastfeeding support program for mothers in Japan by comparing the breastfeeding continuation rate with a control group at 3 months after returning to work. The second objective was to explore the effectiveness of a pamphlet containing information to help mothers returning to work continue breastfeeding by comparing breastfeeding continuation rates in women given the pamphlet and a control group.Methods: This was a quasi-experimental design study with a program group (n=48), pamphlet group (n=46) and control group (n=47) that took place from February 2017 to August 2018. Participants in the program and pamphlet groups were women who planned to return to work within 4–12 months after giving birth, while the control group included women who had been back at work for at least 3 months. The program involved a 90-min breastfeeding class, a pamphlet, a newsletter, and email consultation. The pamphlet group was sent only the pamphlet, while the control group received no intervention. The outcome was breastfeeding continuation rate at 3 months after returning to work.Results: The breastfeeding continuation rate 3 months after returning to work was significantly higher in the program group than in the control group (79.2% vs. 51.1%, p=0.004). After adjusting for background factors, the program intervention had an effect on breastfeeding rates (adjusted odds ratio=4.68, 95% confidence interval: 1.57–13.96; p=0.006). However, comparison of the pamphlet and control groups revealed no significant differences in breastfeeding continuation rates at 3 months after returning to work (69.6% vs. 51.1%, p=0.07).Conclusions: Program intervention resulted in a significant increase in breastfeeding continuation rates 3 months after returning to work. Randomized controlled trials are needed to make this program applicable in practice. Pamphlet intervention resulted in no significant difference, but the proportion of breastfeeding continuation was high; therefore, further study is necessary after examining the contents of the pamphlet.
A Predictive Signature for Oxaliplatin and 5-fluorouracil Based Chemotherapy Inlocally Advanced Gastric Cancer
Authors: Wang Qinchuan , Liu Xiyong , Chen Chen , Chen Jida , Xu Beisi , Chen Lini , Zhou Jichun , Huang Yasheng , Chen Wenjun , Teng Rongyue , Zhao Wenhe , Jin Lidan , Shen Jun , Shen Jianguo , Yen Yun , Wang Linbo 
Published: June 2020

Abstract
Background: Adjuvantchemotherapy(AC)plays a substantial role in the treatment of locally advanced gastric cancer (LAGC), but the response remains poor. Weaims to improve its efficacy in LAGC. Methods: We identified the expression of eight genes closely associated with platinum and fluorouracil metabolism (RRM1, RRM2, RRM2B, POLH, DUT, TYMS, TYMP, MKI67) in the discovery cohort (N=291). And we further validated the findings in TCGA (N=279) and GEO. Overall survival (OS) was used as an endpoint. Univariate and multivariate Cox models were applied. A multivariate Cox regression model was simulated to predict theOS. Results: In the discovery cohort,the univariate Coxmodelindicated that AC was beneficial to high-RRM1, high-DUT, low-RRM2, low-RRM2B, low-POLH, low-KI67, low-TYMS or low-TYMP patients, the results were validated in the TCGA cohort. The multivariate Cox model showed consistent results. Cumulative analysis indicated that patients with low C-Score respond poorly to the AC, whereas thehigh and mediumC-Score patients significantly benefit from AC. A risk model based on the above variables successfully predicted the OS in both cohorts (AUC=0.75 and 0.67, respectively). Further validation in a panel of gastric cancer cell (GC) lines (N=37) indicated that C-Score is significantly associated with IC50 value to fluorouracil. Mutation profiling showed that C-Score was associated with the number and types of mutations. Conclusion: In this study, we successfully simulated a predictive signature for the efficacy of AC in LAGC patients and further explored the potential mechanisms. Our findings could promote precision medicine and improve the prognosis of LAGC patients.
PERAN MODEL BRAIN-BASED LEARNING PADA PEMBELAJARAN SISTEM SARAF DALAM MENINGKATAN LITERASI SAINS SISWA
Authors: SAADAH KUNI 
Published: June 2020

Literasi sains merupakan suatu kemamuan siswa dalan mengidentifikasi pertanyaan guna memperoleh pengetahuan yang baru. Penelitian ini bertujuan untuk mengetahui efektivitas model Brain-Based Learning dalam peningkatan literasi sains siswa pada pembelajaran sistem saraf. Desain penelitian ini yang digunakan adalah Pre-Exsperimental Designs dengan bentuk One-Group Pretest-Posttest Design. Pengambilan sampel menggunakan teknik Purposive Sampling Data yang diambil adalah kemampuan berpikir kritis siswa, rasa ingin tahu siswa, tanggapan siswa, dan tanggapan guru mengenai keterlaksanaan pembelajaran. Instrumen yang digunakan berupa soal pretest posttest, lembar observasi dan rubrik penilaian kemampuan afektif serta psikomotorik siswa, angket tanggapan siswa, dan lembar wawancara tanggapan guru. Pengumpulan data dilakukan dengan menggunakan metode tes, observasi dan angket. Hasil belajar ranah kognitif dianalisis ketuntasan klasikal hasil belajarnya dan uji N-gain. Hasil belajar afektif dan psikomotorik serta tanggapan siswa dianalisis secara deskriptif kuantitatif, sedangkan tanggapan guru dianalisis secara deskriptif kualitatif. Analisis data ditentukan menggunakan aplikasi Microsoft excel. Kemampuan berpikir kritis siswa pada kelas XI MIA 2 hasil uji N-Gain 83,3% dan pada kelas XI MIA 3 75%. Capaian tersebut termasuk dalam kategori tinggi dengan indikator siswa memperoleh nilai ≥70. Rasa ingin tahu siswa kelas XI MIA 2 75% dan pada kelas XI MIA 3 83,3% siswa capaian tersebut termasuk dalam kategori tinggi. Model Brain-Based Learning dapat mencapai indikator keefektifan karena terdapat keberhasilan dan keterpautan model Brain-Based Learning terhadap kemampuan berpikir kritis dan rasa ingin tahu siswa. sehingga dapat disimpulkan bahwa Simpulan: Model Brain-Based Learning efektif untuk peningkatan literasi sains siswa. Kata kunci: Literasi Sains, Brain-Based Learning, Sistem Saraf
Construction and Functional Analysis of the Recombinant Bacteriocins Weissellicin-MBF from Weissella confusa MBF8-1
Authors: Malik Amarila , Yuliantie Elita , Suprahman Nisa Yulianti , Linardi Theresa , Widiyanti Angelina Wening , Haldy Jeanita , Tjia Catherine , Takagi Hiroshi 
Published: June 2020

Background:
Bacteriocins (Bac1, Bac2, and Bac3) from Weissella confusa MBF8-1, weissellicin-
MBF, have been reported as potential alternative substances as well as complements to the existing
antibiotics against many antimicrobial-resistant pathogens. Previously, the genes encoded in the
large plasmid, pWcMBF8-1, and the spermicidal activity of their synthetic peptides, originally discovered
Indonesia, have been studied. Three synthetic bacteriocins peptides of this weissellicin-MBF have
been reported for their potential activities, i.e. antibacterial and spermicidal.

Objective:
The aim of this study was to construct the recombinant Bacteriocin (r-Bac) genes, as well as
to investigate the gene expressions and their functional analysis.

Method:
Here, the recombinant Bacteriocin (r-Bac) genes were constructed and the recombinant peptides
(r-Bac1, r-Bac2, and r-Bac3) in B. subtilis DB403 cells were produced on a large scale. After purification,
using the His-tag affinity column, their potential bioactivities were measured as well as their
antibacterial minimum inhibitory concentrations against Leuconostoc mesenteroides and Micrococcus
luteus, were determined.

Results:
Pure His-tag-recombinant Bac1, Bac2, and Bac3 were obtained and they could inhibit the
growth of L. mesenteroides and M. luteus.

Conclusion:
The recombinant bacteriocin could be obtained although with weak activity in inhibiting
gram-positive bacterial growth.
Synthesis, Characterization, Anti-proliferative Evaluation, and DNA Flow Cytometry Analysis of Some 2-Thiohydantoin Derivatives
Authors: Elhady Heba A. , Al-Shareef Hossa F. 
Published: June 2020

Background and Objective:
Due to the well-documented anti-proliferative activity of
2-thiohydantoin incorporated with pyrazole, oxadiazole, quinazoline, urea, β-naphthyl carbamate and
Schiff bases, they are noteworthy in pharmaceutical chemistry.

Methods:
An efficient approach for the synthesis of a novel series of 2-thiohydantoin derivatives incorporated
with pyrazole and oxadiazole has proceeded via the reaction of the acyl hydrazide with
chalcones and/or triethyl orthoformate. Schiff bases were synthesized by the reaction of the acyl hydrazide
with different aromatic aldehydes. Moreover, Curtius rearrangement was applied to the acyl
azide to obtain the urea derivative, quinazoline derivative, and carbamate derivative.

Results:
The synthesized compounds structures were discussed and confirmed depending on their
spectral data. The anticancer activity of these heterocyclic compounds was evaluated against the breast
cancer cell line (MCF-7), where they showed variable activity. Compound 5d found to have a superior
anticancer activity, where it has (IC50 = 2.07 ± 0.13 μg/mL) in comparison with the reference drug
doxorubicin that has (IC50 = 2.79 ± 0.07 μg / mL). Then compound 5d subjected to further studies such
as cell cycle analysis and apoptosis. Apoptosis was confirmed by the upregulation of Bax, downregulation
of Bcl-2, and the increase of the caspase 3/7percentage.

Conclusion:
Insertion of pyrazole, oxadiazole and, quinazoline moieties with 2-thiohydantoin moiety
led to the enhancement of its anti-proliferative activity. Hence they can be used as anticancer agents.
MANIPULASI TOPURAK (TOTOK, PUKUL, GERAK) UNTUK PENYEMBUHAN NYERI DAN KETEGANGAN OTOT LEHER
Authors: Yuliana Ela , Kushartanti B.M. Wara 
Published: June 2020

Nyeri dan ketegangan otot leher merupakan keluhan muskuloskeletal umum yang sering dirasakan setiap orang (prevalensi 30%-50%). Topurak (Totok, Pukul, Gerak) merupakan salah satu terapi manipulasi. Tujuan penelitian ini adalah untuk menguji efektivitas manipulasi Topurak untuk penyembuhan nyeri dan ketegangan otot leher pasien Klinik Olahraga Terapi dan Rehabilitasi FIK UNY. Rancangan Pre-experimental dengan One Group Pretest-Posttest Design. Teknik pengambilan sampel menggunakan quota sampling yang dihitung dengan rumus Slovin didapatkan quota sebesar 15 orang. Data yang dikumpulkan adalah ROM, skala nyeri, dan skala fungsi baik sebelum maupun sesudah perlakukan. Paired Samples t Test digunakan untuk menganalisis data ROM dan uji Wilcoxon untuk data skala nyeri maupun skala fungsi. Hasil penelitian menunjukkan adanya peningkatan ROM pada gerakan fleksi, ekstensi, left lateral flexion, right lateral flexion, left rotation, dan right rotation. Didapatkan juga adanya penurunan skala nyeri serta peningkatan skala fungsi leher setelah manipulasi Topurak (p<0,05). Berdasarkan hasil tersebut, maka dapat disimpulkan bahwa manipulasi Topurak efektif untuk penyembuhan nyeri dan ketegangan otot leher. TOPURAK MANIPULATION (TOUCH, PUNCH, MOTION) FOR HEALING OF PAIN AND NECK MUSCLE TENSIONAbstractNeck pain and muscle tension is a common musculoskeletal complaint that is often felt by everyone (prevalence of 30% -50%). Topurak (Touch, Pukul, Motion) is a manipulation therapy. and neck muscle tension of FIK UNY Sports and Therapy Sports and Rehabilitation Clinic patients. Pre-experimental design with One Group Pretest-Posttest Design. The sampling technique uses quota sampling which is calculated by Slovin formula obtained quota of 15 people. Data collected were ROM, pain scale, and function scale both before and after treatment. Paired Samples t Test is used to analyze ROM data and Wilcoxon test for pain scale and function scale data. The results showed an increase in ROM in flexion, extension, left lateral flexion, right lateral flexion, left rotation, and right rotation. There was also a decrease in pain scale and an increase in the scale of neck function after Topurak manipulation (p <0.05). Based on these results, it can be concluded that Topurak manipulation is effective for healing neck pain and muscle tension.
Analisis Perbedaan Kemampuan Bank Shoot Dari Sisi Kanan Dan Sisi Kiri Pada Anggota Ekstrakurikuler Bolabasket Putra Usia 11-14 Tahun Di Yogyakart
Authors: Putro Kukuh Hardopo 
Published: June 2020

Permasalahan yang terjadi dalam penelitian ini adalah anggota ekstrakurikuler bolabasket putra usia 11-14 tahun di yogyakarta belum sempurna dalam melakukan bank shoot baik dalam posisi maupun gerakan. Penelitian ini bertujuan untuk mengetahui perbedaan kemampuan bank shoot dari sisi kanan dan dari sisi kiri pada anggota ekstrakurikuler bolabasket putra usia 11-14 tahun di Yogyakarta. Penelitian ini merupakan penelitian deskriptif dengan metode survei. Sampel dalam penelitian ini diambil secara random sampling, yang berjumlah 30 siswa. Instrumen penelitian menggunakan tes bank shoot dari AAHPER dengan validitas 0,609 dan reliabilitas 0.757. Teknik pengumpulan data dengan metode tes dan pengukuran. Analisis data dengan ujji prasyarat dan uji t. Hasil uji statistik diperoleh nilai uji-t bank shoot sisi kanan dan kiri memiliki nilai t hitung -1,417 dan nilai t tabel dengan df 14 pada taraf signifikansi 5% sebesar 2,14. p = 0,178, karena p > 0,05 maka tidak terdapat perbedaan yang signifikan. Sehingga dapat disimpulkan bahwa tidak terdapat perbedaan yang signifikan antara kemampuan bank shoot dari sisi kanan dan kiri pada anggota ekstrakurikuler bolabasket putra usia 11-14 tahun di Yogyakarta. Analysis of the Difference in the Capability of Bank Shoot From the Right and Left Side of Male Bolabasket Extracurricular Members Aged 11-14 Years Old in YogyakartaAbstractProblems that occur in this study are members of male basketball basketball extracurricular members aged 11-14 years in Yogyakarta not yet perfect in doing bank shoots both in position and movement. This study aims to determine the differences in the ability to shoot banks from the right side and from the left side on the extracurricular members of the basketball boy age 11-14 years in Yogyakarta. This research is a descriptive study with a survey method. The sample in this study was taken by random sampling, which amounted to 30 students. The research instrument used a bank shoot test from AAHPER with a validity of 0.609 and reliability of 0.757. Data collection techniques with test and measurement methods. Data analysis with prerequisite tests and t tests. Statistical test results obtained t-test value shoot banks right and left side has a t value of -1.417 and t table value with df 14 at a significance level of 5% of 2.14. p = 0.178, because p> 0.05 there is no significant difference. So it can be concluded that there is no significant difference between the ability to shoot banks from the right and left sides of male basketball extracurricular members aged 11-14 years in Yogyakarta.
Dinámicas de apropiación social de las TIC y su impacto en las comunidades educativas
Authors: Hernández Mena Andrés David , Merlano Tous Nuria 
Published: June 2020

Las tecnologías de la información y las comunicaciones (TIC) se han convertido en un elemento tácito para la consecución de los proyectos educativos eficientes a lo largo y ancho de la comunidad educativa a nivel nacional. Se han realizado variadas reflexiones sobre la implementación de estas en el aparato educativo, sin embargo, los estudios puntuales de casos aún son mínimos en comparación con otros tipos de análisis. Este artículo está basado en una investigación que tiene como fundamento inicial el ahondar sobre la apropiación social mediada por las TIC en dos instituciones educativas de la ciudad de Cartagena de indias, para optar al título de magister, de la maestría en educación SUE Caribe en la Universidad de Cartagena. Se observó la formación que tanto docentes como estudiantes están teniendo en estos ambientes, y para tener un mejor desarrollo en la investigación, en lo que respecta a la metodología se usó el paradigma mixto con un enfoque descriptivo, con el fin de dar mayor flexibilidad al análisis de las evidencias y tabulaciones resultantes de las visitas y análisis de fuentes.
Innovación didáctica enmarcada en el aprendizaje basado en problemas (ABP) para la enseñanza de la Biología
Authors: Aguado O. Anet , Campo F. Álvaro 
Published: June 2020

Los componentes teóricos-conceptuales y metodológicos en este artículo, provienen principalmente de una experiencia de tres años de trabajo con la metodología ABP como parte de una investigación orientada desde la Maestría en educación SUE Caribe IX cohorte de la Universidad de Córdoba, con el propósito de determinar la influencia de la metodología ABP en el desarrollo de la competencia científica de los estudiantes de Noveno grado en el área de las Ciencias Naturales/Biología. El estudio está enmarcado dentro del diseño cuasiexperimental de series cronológicas con 4 evaluaciones (una pre y tres post) con dos grupos intactos: un grupo experimental (usó la metodología ABP) y un grupo control (no usó el ABP), cada uno conformado por 30 estudiantes. Los instrumentos de medición fueron cuestionarios con 20 preguntas de selección múltiple única respuesta. Para el análisis de resultado se realizó ANOVA intra e inter-grupo. Los resultados obtenidos a lo largo del proceso de la investigación pudieron establecer que la implementación del enfoque ABP permitió la apropiación de teorías, contenidos y saberes con los que el estudiante afrontó de mejor manera situaciones problemas en las cuales requirió de indagar, explicar y aplicar comprensiva y responsablemente los conocimientos adquiridos, mejorando sustancialmente la competencia científica en los estudiantes del grupo experimental en comparación con los resultados del grupo control.
Reflexiones sobre la construcción de pensamiento crítico en la Escuela Montemariana y el ejercicio de la metacognición en las instituciones: Notas para un debate
Authors: Daniels Puello Amaranto 
Published: June 2020

Este artículo de reflexión surge de los resultados de una primera aproximación analítica de los proyectos educativos institucionales de cinco instituciones educativas en los Montes de María-Colombia; le apunta a explorar los desafíos, procesos y acciones requeridas para la formación de pensamiento crítico en la escuela montemariana, en el marco de la relación escuela-territorio y sus diversas funciones, la cual tiene como elementos claves para su comprensión: la complejidad de la sociedad, el aumento de la diversidad social y/o cultural e, igualmente, las tensiones que surgen del contexto económico, político y social de los Montes de María, subregión colombiana que intenta avanzar desde el conflicto al restablecimiento de la paz.
On ‘affective’ exceptions to sound change: an example from the Mojeño (Arawakan) kinship terminology system
Authors: De Carvalho Fernando O. 
Published: June 2020

This paper discusses a postulated non-sound change-based development derived from the detection of an exception to a regular segmental correspondence and shows how this proposal receives independent support from internal etymologization within the domain of kinship terms. The affricate in the Proto-Mojeño etymon *-ótse ‘grandmother’ is hypothesized to derive from affective strengthening of a fricative *s, thus modifying the expected reflex *-óse via affective or phonosymbolic affrication. The fact that the predicted fricative reflex is found when *-óse ‘grandmother’ occurs as a member of a compound for ‘mother-in-law’, a meaning not subject to affective modification, offers striking support for the hypothesis. The paper illustrates how internally structured lexical fields — where relations of partial (internal) cognation exist — such as kinship terminology systems, provide an interesting testing ground for claims on affective, non-lautgesetzlich formal modifications, given the fact that etymologically related forms belong to domains (such as ‘blood relative’ versus ‘affine relative’) that differ in crucial ways as far as the affective dispositions and attitudes of speakers are concerned.
Implementing Emergency Power Supply for Lighting and Sound System for a Mosque based on light and Movement Sensors
Authors: Ulinuha Agus , Wicaksana Rizky Dian 
Published: June 2020

Emergency power supply is necessary for a mosque particularly when prayer is happening while power cuts. The important devices required to remain alive at this event are lighting and sound system. For this purpose, a battery is needed to supply the devices and the lighting and movement sensors that used to control the emergency power supply. The battery is powered by a solar photovoltaic (PV) panel. The power supply switching between main power and battery is regulated by Automatic Transfer Switch. A 20 Ah, 12 Volt battery supplied by 50 WP solar PV panel is used to back up the power for 6 W LED light and sound system. The system is implemented on the Mosque of Al-Bakri, Mojosongo, City of Surakarta. Research purpose of implementing this system is to solve the problem of power cuts during worship. This research used survey and measurement methods. In conclusion of implementing this system the prayer may continue even the electricity went out.
Factors Related to Compliance of ARV Medication in HIV Patients at RSCM Jakarta
Authors: Debby Chryest , Sianturi Sondang Ratnauli , Susilo Wilhelmus Hary 
Published: June 2020

Antiretroviral therapy is believed not to be able to cure the disease; however, it can reduce mortality and morbidity. It also improves the quality of life of people with HIV. The success of the HIV/AIDS treatment is determined by adherence to antiretroviral therapy. ARV therapy is given in a long run and can be said as optimal if the compliance reaches more than 95%. The purpose of this study was to determine the relationship between certain factors and adherence to ARV therapy in people with HIV/AIDS. The design of this study was a descriptive correlational study with a cross-sectional approach. A total of 198 patients were recruited through a purposive sampling technique. The result of the study showed that there was no relation between adherence with age (p-value of 0.327), education (p-value of 0.859), and treatment (p-value of 0.74). From this study, it can be recommended that nurses need to improve their HIV counseling skills, especially about the benefits of adherence using a communicative media. Hospitals should also encourage more support to achieve better adherence in patients living with HIV/AIDS. Keyword: Adherence, HIV/AIDS, Antiretroviral Therapy