bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Ethanol Exposure Inhibits the Differentiation of Hippocampal Dentate Gyrus Granule Cells in a Mouse Model of Fetal Alcohol Spectrum Disorders
Authors: Xu Wenhua , Li Hui , He Caigu , Frank Jacqueline , Chen Gang 
Published: March 2020

BackgroundAlcohol consumption during pregnancy may damage the developing central nervous system of the fetus and lead to brain structural and functional deficits in the children, known as fetal alcohol spectrum disorders. The underlying mechanisms have not been fully elucidated. Previously, using a third trimester–equivalent mouse model, ethanol (EtOH)‐induced behavioral deficits (including spatial learning and memory dysfunction) in the mice were detected on postnatal day (PD) 35. The hippocampal formation is critically involved in spatial learning/memory and contains 2 major neuron populations: the pyramidal cells in the hippocampus proper and the dentate gyrus granule cells (DGGCs) in the dentate gyrus (DG). In rodents, while the pyramidal cells are almost exclusively generated prenatally, the DG granule neurons are majorly generated during the first 2 weeks postnatally, which coincides with the period of EtOH exposure in our mouse model. Therefore, in the current study the effects of EtOH exposure on the development of the DGGCs were examined.MethodsC57BL/6 mice were treated with 4 g/kg of EtOH by intubation on PD 4 to 10 to mimic alcohol exposure to the fetus during the third trimester in humans, and the development of DGGCs was examined by immunohistochemistry and quantified on PD 35.ResultsEtOH exposure does not affect the number of total or newly generated DGGCs, but reduces the number of mature DGGCs on PD 35 in both male and female mice. The ratio of immature DGGCs over total DGGCs was increased, and the ratio of mature DGGCs over total DGGCs was decreased by EtOH exposure. In addition, no sex‐dependent effects of EtOH treatment were detected.ConclusionOur data indicate that EtOH exposure in mice during PD 4 to 10 does not affect the generation/proliferation but inhibits the differentiation of the DGGCs on PD 35.
Association of Cannabis Use With Intimate Partner Violence Among Couples With Substance Misuse
Authors: Flanagan Julianne C. , Leone Ruschelle M. , Gilmore Amanda K. , McClure Erin A. , Gray Kevin M. 
Published: March 2020

Background and ObjectivesThere is a well‐established causal link between substance use and intimate partner violence (IPV) perpetration and victimization. However, little is known about the complex emerging relationship between cannabis use and IPV. Because cannabis is the most commonly used drug in the United States and is associated with numerous IPV risk factors such as alcohol use, it is important to examine this relationship in greater detail.MethodThe current exploratory study examined the association between (a) self‐reported cannabis use during the past 90 days and (b) Δ9‐tetrahydrocannabinol (THC) urine drug screens and IPV perpetration and victimization in a sample of 30 alcohol or drug‐misusing community couples (N = 60 individual participants).ResultsThe majority of participants (n = 50 individuals, 83.3%) had concordant cannabis self‐reported and urine drug screen results. After accounting for demographic variables and quantity and frequency of alcohol and stimulant use, greater quantity and frequency of cannabis use as well as positive THC urine drug screen results were associated with greater physical IPV victimization, and greater quantity and frequency of cannabis were associated with greater IPV psychological victimization and perpetration, and physical IPV victimization.Conclusion and Scientific SignificanceFindings emphasize the unique and important role that cannabis plays in the occurrence of IPV among intact couples. Findings also underscore the feasibility and utility of integrating confirmatory biological samples into future studies on this topic in order to advance the science in this area. (Am J Addict 2020;00:00–00)
Alcohol Use Disorder Among Adults Recovered From Substance Use Disorders
Authors: Rhee Taeho Greg , Rosenheck Robert A. 
Published: March 2020

Background and ObjectivesAlcohol use is often overlooked and underestimated among patients recovered from substance dependence. The prevalence and correlates of alcohol use disorder (AUD) among adults recovered from substance use disorders (SUDs) are estimated in this study.MethodsA nationally representative cross‐sectional analysis of the National Epidemiological Survey on Alcohol and Related Conditions Wave‐III was used in this study. Survey respondents, aged 18 or older, who recovered from SUDs, based on Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM‐5) criteria (n = 2061 unweighted), were included. A total of three comparison groups were identified using DSM‐5 criteria (1) current AUD, (2) former AUD, and (3) never had AUD. The prevalence of these groups was estimated; medical and psychiatric comorbidities and health‐related quality of life were compared; and factors associated with having a current AUD when compared with those with former AUD and those who never had AUD were examined, controlling for other covariates.ResultsAbout 5.7% of US adults, nationally representative of 14.2 million, have been reported to have recovered from past SUDs. Of these, 28.9% met criteria for current AUD and 48.4% had former AUD. When compared with those who never had AUD, factors associated with having a current AUD included the following: living in urban areas (P = .019), having a bipolar 1 disorder (P < .001), and a history of lifetime incarceration (P = .004).Discussion and ConclusionNearly one‐third of adults recovered from SUDs had current AUD, and several behavioral factors were associated with having a current AUD when compared with those who never had AUD.Scientific SignificanceOur study highlights the substantial risk of AUD in adults who have successfully recovered from SUDs. (Am J Addict 2020;00:00–00)
Frequency of food allergy in school‐aged children in eight European countries—The EuroPrevall‐iFAAM birth cohort
Authors: Grabenhenrich Linus , Trendelenburg Valérie , Bellach Johanna , Yürek Songül , Reich Andreas , Fiandor Ana , Rivero Daniela , Sigurdardottir Sigurveig , Clausen Michael , Papadopoulos Nikolaos G. , Xepapadaki Paraskevi , Sprikkelman Aline B. , Dontje Bianca , Roberts Graham , Grimshaw Kate , Kowalski Marek L. , Kurowski Marcin , Dubakiene Ruta , Rudzeviciene Odilija , Fernández‐Rivas Montserrat , Couch Philip , Versteeg Serge A. , van Ree Ronald , Mills Clare , Keil Thomas , Beyer Kirsten 
Published: March 2020

AbstractBackgroundThe prevalence of food allergy (FA) among European school children is poorly defined. Estimates have commonly been based on parent‐reported symptoms. We aimed to estimate the frequency of FA and sensitization against food allergens in primary school children in eight European countries.MethodsA follow‐up assessment at age 6‐10 years of a multicentre European birth cohort based was undertaken using an online parental questionnaire, clinical visits including structured interviews and skin prick tests (SPT). Children with suspected FA were scheduled for double‐blind, placebo‐controlled oral food challenges (DBPCFC).ResultsA total of 6105 children participated in this school‐age follow‐up (57.8% of 10 563 recruited at birth). For 982 of 6069 children (16.2%), parents reported adverse reactions after food consumption in the online questionnaire. Of 2288 children with parental face‐to‐face interviews and/or skin prick testing, 238 (10.4%) were eligible for a DBPCFC. Sixty‐three foods were challenge‐tested in 46 children. Twenty food challenges were positive in 17 children, including seven to hazelnut and three to peanut. Another seventy‐one children were estimated to suffer FA among those who were eligible but refused DBPCFC. This yielded prevalence estimates for FA in school age between 1.4% (88 related to all 6105 participants of this follow‐up) and 3.8% (88 related to 2289 with completed eligibility assessment).InterpretationIn primary school children in eight European countries, the prevalence of FA was lower than expected even though parents of this cohort have become especially aware of allergic reactions to food. There was moderate variation between centres hampering valid regional comparisons.
Quality of life of adults born very preterm or very low birth weight: A systematic review
Authors: van der Pal Sylvia , Steinhof Malte , Grevinga Manon , Wolke Dieter , Verrips Gijsbert (Erik) 
Published: March 2020

AbstractAimTo establish differences in health‐related quality of life (HRQoL) in adults born term and those born very preterm (VPT) and/or with a very low birth weight (VLBW).MethodsOur systematic review is preregistered under PROSPERO‐ID CRD42018084005. Studies were eligible for inclusion if their authors had stated the HRQoL of adults (18 years or older) born VPT (<32 weeks of gestation) or VLBW (<1500 g of birth weight) had been measured, if written in English, and if they reported a comparison with a control group or valid norms. We searched Pubmed, Scopus, Psycinfo, Web of Science, Embase and contacted experts in this field. Non‐response and other bias‐related problems were evaluated.ResultsWe included 18 studies of 15 unique cohorts from 11 countries. In 11 studies, no differences in HRQoL between VPT or VLBW and term‐born adults were found; four studies found lower HRQoL in VPT/VLB adults; and evidence from three studies was inconclusive. Disability, sex and age were associated with HRQoL.ConclusionThere is no conclusive evidence that HRQoL differs between term‐born adults and those born VPT or with a VLBW. The comparability of studies was restricted by differences between HRQoL measurements, age ranges at assessment and definition of disability.
Children with vaccination granulomas and aluminum contact allergy: Evaluation of predispositions, avoidance behavior, and quality of life
Authors: Hoffmann Stine S. , Thyssen Jacob P. , Elberling Jesper , Hansen Kirsten S. , Johansen Jeanne D. 
Published: March 2020

AbstractBackgroundAluminum contact allergy is mostly seen in children with vaccination granulomas, following immunization with aluminum‐adsorbed childhood vaccines.ObjectivesTo characterize a cohort of children with vaccination granulomas and aluminum allergy concerning early life conditions, exacerbating factors, avoidance behavior, treatments, and potential impact on quality of life.MethodsA questionnaire study was conducted among 177 children aged 0 to 15 years with vaccination granulomas and aluminum allergy, and a reference group of 61 children aged 3 to 14 years with various types of dermatitis undergoing patch testing.ResultsAll children in the granuloma group were reportedly affected by itch. Infection exacerbated the itch in 59%. Other worsening factors were eating tin‐foiled/canned food (31%) and use of aluminum‐containing sunscreen (46%). Many parents took precautions to avoid aluminum exposure. Children with granulomas were more likely to be nonadherent to the National Vaccination Program than the reference group (27% vs 2%, P < .001). Parents in the granuloma group reported a decreased life quality for both parents and children compared with the reference group.ConclusionsItching vaccination granulomas and aluminum allergy have a considerable negative impact on affected children and their families, causing avoidance behavior, reduced adherence to vaccination programs, and a negative effect on the overall life quality.
Data envelopment analysis and robust optimization: A review
Authors: Peykani Pejman , Mohammadi Emran , Saen Reza Farzipoor , Sadjadi Seyed Jafar , Rostamy‐Malkhalifeh Mohsen 
Published: March 2020

AbstractThis paper reviews the milestone approaches for handling uncertainty in data envelopment analysis (DEA). This paper presents the detailed classifications of robust data envelopment analysis (RDEA). RDEA is appropriate for measuring the efficiencies of decision‐making units in the presence of the data and distributional uncertainties. This paper reviews scenario‐based and uncertainty set of DEA models. It covers 73 studies from 2008 to 2019. The paper concludes with suggestions about the guidelines for future researches in the field of RDEA.
Marital Conflict in the Context of Novel Stress: Associations with Physiological Stress Functioning
Authors: Seiter Natasha S. , Lucas‐Thompson Rachel G. 
Published: March 2020

ObjectivesThe goal of this study was to investigate associations of the positivity and negativity of couple communication behaviors during a novel stressor, representative of dyadic coping, with diurnal cortisol patterns, an indication of stress physiological functioning.BackgroundPrevious research suggests that less positive and more negative couple interactions about reoccurring relationship issues are stressful and, as a result, are associated with physiological stress dysregulation. Past research has also indicated that behaviors during novel, as opposed to reoccurring, stressors are uniquely predictive of couple outcomes because behaviors during novel stressors are indicative of patterns of dyadic coping. However, there is not yet evidence linking couple behaviors in response to novel stressors to physiological stress functioning.MethodsSixty‐one (N = 122 individuals) heterosexual couples completed a novel stress task, and recordings of their interactions were coded for negative and positive communication behaviors. Couples provided saliva samples at home for 2 days, which were assayed for diurnal cortisol concentrations.ResultsResults of linear regression and structural equation modeling analyses suggested that women's greater positive, in relation to negative, communication behavior during the novel stressor was associated with women's greater cortisol awakening levels and cortisol awakening responses. Men's greater positive behavior was associated with men's and women's greater cortisol awakening levels, that is, signs indicating healthy physiological functioning.ConclusionCouples' dyadic coping has implications for the functioning of stress systems.ImplicationsSpecifically, couples' communication quality during novel stressors may protect from physiological stress dysregulation; the manner in which couples treat each other when facing novel stress can get “under the skin.”
Exploring Home Management Houses: Part II Two Case Studies: The University of Georgia and Texas Tech University
Authors: Nickols Sharon Y. , Allison Barbara N. 
Published: March 2020

Home management courses, and the houses where those course principles and practices were applied, played an historical role in the home economics curriculum in the United States from the 1920s to the 1980s. The residence course was taught in a variety of settings. However, the course was taught most often in houses located on campus. Using multiple research methods, this study explored home management courses and residences at the University of Georgia and Texas Tech University. Part I which was published in the March issue of the Family & Consumer Sciences Research Journal provided a general historical overview and a case study of the home management houses at Kansas State University. Eventually, the home management houses were repurposed to meet changing academic, research, and public service needs over their decades‐long history. Opportunities for future research are explored.
Depression in diabetic foot ulcer: Associated factors and the impact of perceived social support and anxiety on depression
Authors: Polikandrioti Maria , Vasilopoulos Georgios , Koutelekos Ioannis , Panoutsopoulos Georgios , Gerogianni Georgia , Alikari Victoria , Dousis Evaggelos , Zartaloudi Afroditi 
Published: March 2020

AbstractDiabetic foot ulcer (DFU) exerts a heavy physical and emotional burden on patients with diabetes mellitus. The purpose of the present study was to explore the impact of anxiety and perceived social support on depression of DFU patients well as patients' characteristics associated with depression. The sample of the study consisted of 180 DFU patients. Data collected by the completion of “Self‐rating Depression/Anxiety Scale‐ Zung” (SDS/SAS) and the Multidimensional Scale of Perceived Social Support (MSPSS). Patients had moderate levels of anxiety and depression (median: 36, 42, respectively) and high levels of perceived social support from their significant ones, their family and friends (median: 24, 24, 17, respectively). After multiple regression factors that were found to have an impact on depression after taking into account all other factors, were patient's age of above 70 years, patient's anxiety and the social support they received from their significant ones. More specifically, patients aged above 70 years had 9.51 points higher depression than patients aged <50 years of age (β = 9.51, 95% CI: [0.76, 18.25], P = .034). Moreover, one point increase in patient's anxiety score indicated an increase of 0.71 points in patient's depression (β = 0.71, 95% CI: [0.43, 1.00], P = .001). On the contrary, one point increase in patient's social support from their significant ones indicated a decrease of 1.52 points in patient's depression (β = −1.52, 95% CI: [−0.25, −2.79], P = .020). Clinically, a better understanding of factors having an impact on depression on DFU may provide an essential in planning cost effective interventions.
Researching children: some methodological and ethical considerations
Authors: Coyne Imelda T. 
Published: March 2020

Summary

This paper examines some of the methodological issues and ethical considerations in researching children.
Collecting data from children raises issues of informed consent, establishing rapport, and privacy and confidentiality.
Children's consent to research remains a contentious issue that requires further deliberations.
Researchers need to be flexible in their research with children and be cognisant of the strategies that can be used to enhance the quality of responses from children.
Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro‐myelinating genes
Authors: Huff Tyler C. , Sant David W. , Camarena Vladimir , Van Booven Derek , Andrade Nadja S. , Mustafi Sushmita , Monje Paula V. , Wang Gaofeng 
Published: March 2020

AbstractAscorbic acid (vitamin C) is critical for Schwann cells to myelinate peripheral nerve axons during development and remyelination after injury. However, its exact mechanism remains elusive. Vitamin C is a dietary nutrient that was recently discovered to promote active DNA demethylation. Schwann cell myelination is characterized by global DNA demethylation in vivo and may therefore be regulated by vitamin C. We found that vitamin C induces a massive transcriptomic shift (n = 3,848 genes) in primary cultured Schwann cells while simultaneously producing a global increase in genomic 5‐hydroxymethylcytosine (5hmC), a DNA demethylation intermediate which regulates transcription. Vitamin C up‐regulates 10 pro‐myelinating genes which exhibit elevated 5hmC content in both the promoter and gene body regions of these loci following treatment. Using a mouse model of human vitamin C metabolism, we found that maternal dietary vitamin C deficiency causes peripheral nerve hypomyelination throughout early development in resulting offspring. Additionally, dietary vitamin C intake regulates the expression of myelin‐related proteins such as periaxin (PRX) and myelin basic protein (MBP) during development and remyelination after injury in mice. Taken together, these results suggest that vitamin C cooperatively promotes myelination through 1) increased DNA demethylation and transcription of pro‐myelinating genes, and 2) its known role in stabilizing collagen helices to form the basal lamina that is necessary for myelination.
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Exposure of female mice to perfluorooctanoic acid suppresses hypothalamic kisspeptin‐reproductive endocrine system through enhanced hepatic fibroblast growth factor 21 synthesis, leading to ovulation failure and prolonged dioestrus
Authors: Zhang Yajie , Cao Xinyuan , Chen Lin , Qin Yaoyao , Xu Ye , Tian Ying , Chen Ling 
Published: March 2020

AbstractPerfluorooctanoic acid (PFOA) is widely used in household applications. High‐dose exposure to PFOA has been associated with increased risks of infertility and premature ovarian insufficiency in woman. PFOA can alter hepatic gene expression by activating peroxisome proliferator‐activated receptor α (PPARα). The present study investigated whether exposure to PFOA via PPARα activation alters the synthesis of hepatic fibroblast growth factor 21 (FGF21) to disturb female neuroendocrine and reproductive function. In the present study, we show that the oral administration of PFOA (2 or 5 mg kg‐1) in adult female mice (PFOA mice) caused prolonged dioestrous, a reduction in the number of corpora lutea and decreased levels of hypothalamic gonadotrophin‐releasing hormone, serum progesterone and luteinising hormone (LH). Exposure to PFOA decreased the expression of vasopressin in the suprachiasmatic nucleus (SCN) and kisspeptin in the anteroventral periventricular nucleus (AVPV) with deficits in preovulation or oestrogen‐induced LH surge. PFOA via activation of PPARα increased dose‐dependently hepatic FGF21 expression, leading to elevated serum and hypothalamic FGF21 concentrations. Treatment of PFOA mice with the PPARα antagonist GW6471 or the FGF21 inhibitor PD173074 rescued SCN vasopressin and AVPV‐kisspeptin expression. Either administration of GW6471 and PD173074 or treatment with vasopressin and the G protein coupled receptor 54 agonist kisspeptin‐10 in PFOA‐mice was able to recover the regular oestrous cycle, ovulation ability, LH surge production and reproductive hormone levels. The present study provides in vivo evidence that exposure to PFOA (≥2 mg kg‐1) in mice causes down‐regulation of the kisspeptin‐reproductive endocrine system by enhancing PPARα‐mediated hepatic FGF21 expression. The liver‐brain reproductive endocrine disorder caused by PFOA exposure may lead to prolonged dioestrous and ovulation failure.
The Relationship between Written District Policies and School Practices among High‐Need Districts in New York State
Authors: Boehm Rebecca , Schwartz Marlene B. , Lowenfels Ann , Brissette Ian , Pattison Mary Jo , Ren Jia 
Published: March 2020

ABSTRACTBACKGROUNDThis study tested the hypothesis that written district wellness policies are associated with higher rates of implementation of nutrition and physical activity practices.METHODSWritten wellness policies and building level practices were assessed for schools (N = 295) within high‐need districts (N = 70) in New York State. The relationship between policies and practices was measured using multi‐level mixed‐effects logistic regressions.RESULTSOverall, stronger written district policies significantly increase the likelihood of practice implementation in schools. This relationship is strongest for physical education and physical activity items, followed by nutrition standards for competitive foods in middle and high schools. Most elementary schools implemented nutrition practices with or without a policy and there were differences in implementation rates between elementary and middle/high schools. When examined separately, policies were for the most part not significantly associated with implementation of corresponding practices.CONCLUSIONSStrong and comprehensive written policies are associated with higher rates of practice implementation overall, but the consistency of this relationship varies by policy‐practice domain. The newer policy topics areas of school wellness promotion and marketing were less frequently included in written policies. Future research should examine whether districts that strengthen their written policies achieve greater implementation over
time.