bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESTIMASI BIAYA KONSTRUKSI GEDUNG DENGAN COST SIGNIFICANT MODEL
Authors: Astana I Nyoman Yudha 
Published: December 2019

<p>Estimasi biaya proyek sangat diperlukan dalam perencanaan sebuahproyek. Pada tahap awal, estimasi biaya digunakan untuk mengetahui berapabesar biaya yang dibutuhkan untuk mewujudkan suatu proyek. Denganketerbatasan waktu dan informasi maka <em>Cost Significant Model</em> merupakan metode estimasi yang mudahdan efektif untuk memberikan gambaran awal biaya proyek.Penelitian ini bertujuan untuk mendapatkan suatu model estimasi biayakonstruksi gedung pemerintah di Kabupaten Jembrana, Provinsi Bali, dengan mengambil data sekunder dari lima belas proyek gedungpemerintah. Prinsip yang digunakan untuk mendapatkanmodel biaya adalah identifikasi <em>cost significant item</em> yang berpengaruh terhadaptotal biaya pekerjaan, kemudian dianalisis untuk menghasilkan rumusanpersamaan regresi.Hasil penelitian menunjukkan bahwa komponen pekerjaan yang secarasignifikan mempengaruhi biaya konstruksi gedung pemerintah di KabupatenJembrana adalah biaya pekerjaan beton, biaya pekerjaan kap/atap, biayapekerjaan finishing/style Bali, dan biaya pekerjaan pintu &amp; jendela. Model estimasi dinyatakan dalam persamaanY=510,481+0,888X<sub>5</sub>+1,385X<sub>6</sub>+1,328X<sub>12</sub>+1,726X<sub>8</sub>,dimana Y=Biaya pembangunan gedung (Rp/m<sup>2</sup>), X<sub>5</sub>=Biaya pekerjaan beton (Rp/m<sup>2</sup>), X<sub>6</sub>=Biaya pekerjaan kap (Rp/m<sup>2</sup>), X<sub>12</sub>=Biaya pekerjaan finishing/style Bali (Rp/m<sup>2</sup>), dan X<sub>8</sub>=Biaya pekerjaan pintu dan jendela (Rp/m<sup>2</sup>). Penyimpangan model biaya konstruksi gedung dengan <em>cost significantmodel</em> adalah rata-rata 1,81% untuk yang bernilai positif dan 2,06% untuk yangbernilai negatif.</p><p> </p><p><strong>Kata kunci</strong> : Estimasi Biaya, Cost Significant Model, Konstruksi Gedung</p>
MODEL LOGIT DAN PROBIT DALAM ANALISIS SENSITIVITAS TARIF TOLO SOLO-NGAWI RUAS KARTASURA-PALANG JOGLO BERDASARKAN WILLINGNESS TO PAY (WTP)
Authors: Handayani Dewi , Putri Hera Cahyaning , MHM Amirotul 
Published: December 2019

<p class="Abstract">Proyek jalan tol Solo-Ngawi merupakan bagian dari proyek mega pembangunan jalan tol Trans Jawa yang diprakarsai oleh pemerintah dan saat ini masih dalam proses pembangunan. PT Solo Ngawi Jaya (SNJ) selaku perusahaan pengelola tol Solo-Ngawi perlu menentukan tarif tol yang sesuai dengan rencana bisnis sekaligus realisasi kemampuan calon pengguna pulsa pada saat beroperasi. Penentuan tingkat suku bunga yang sesuai akan mempengaruhi kemajuan pembangunan ekonomi daerah. Oleh karena itu, tujuan dari penelitian ini adalah untuk mengetahui bagaimana sensitivitas tarif tol tol Solo-Ngawi berdasarkan potensi pengguna Wajib bayar (WTP). Data primer diperoleh dengan membagikan kuesioner preferensi yang telah diajukan kepada pengguna kendaraan roda empat di segmen jalan arteri Kartasura-Palang Joglo. Data lebih lanjut yang diperoleh akan dianalisis dengan model logit dan probit. Berdasarkan hasil analisis, ditemukan bahwa pengaruh perubahan tarif pada jumlah WTP pada model logomial binomial lebih sensitif daripada model probit pada kondisi perjalanan yang sama. Rentang tarif dari perubahan tarif ke WTP pada model log binomial lebih besar daripada kisaran nilai dalam model probit.</p><p class="Abstract"> </p><p class="Abstract"><strong>Kata Kunci</strong>: <em>sensitivitas, Willingness to Pay (WTP), logit binomial, probit biner Introduction</em></p>
Fault Reactivation and Induced Seismicity During Multistage Hydraulic Fracturing: Microseismic Analysis and Geomechanical Modeling
Authors: Zhang Fengshou , Yin Zirui , Chen Zhaowei , Maxwell Shawn , Zhang Lianyang , Wu Yinghui 
Published: December 2019

SummaryThis paper presents a case study of fault reactivation and induced seismicity during multistage hydraulic fracturing in Sichuan Basin, China. The field microseismicity data delineate a fault activated near the toe of the horizontal well. The spatio-temporal characteristics of the microseismicity indicate that the seismic activity on the fault during the first three stages is directly related to the fluid injection, while after Stage 3, the seismic activity is possibly due to the relaxation of the fault. The fault-related events have larger magnitudes and different frequency-magnitude characteristics compared to the fracturing-related events. Three-dimensional (3D) fully coupled distinct element geomechanical modeling for the first two hydraulic fracturing stages and a shut-in stage between them is performed. The modeling result generates features of microseismicity similar to that of the field data. The energy budget analysis indicates that the aseismic deformation consumes a major part of the energy. The simulated fault shear displacement is also consistent with the casing deformation measured in the field. The model is also used to investigate the impact of possible operational changes on expected seismic responses. The results show that lower injection rate and lower fluid viscosity would be helpful in reducing casing deformation but not in mitigating seismicity. Decreasing the total fluid injection volume is an effective way to mitigate the seismicity, but it may hinder the stimulation of the reservoir formation and the production of the well.
Nomogram for predicting the survival of gastric adenocarcinoma patients who receive surgery and chemotherapy
Authors: Wang Chao-Yang , Yang Jin , Zi Hao , Zheng Zhong-Li , Li Bing-Hui , Wang Yang , Ge Zheng , Jian Guang-Xu , Lyu Jun , Li Xiao-Dong , Ren Xue-Qun 
Published: December 2019

Abstract
Background: Surgery is the only way to cure gastric adenocarcinoma (GAC), and chemotherapy is the basic adjuvant management for GAC. A significant prognostic nomogram for predicting the respective disease-specific survival (DSS) rates of GAC patients who receive surgery and chemotherapy has not been established.Objective: We were planning to establish a survival nomogram model for GAC patients who receive surgery and chemotherapy.
Methods: We identified 5764 GAC patients who had received surgery and chemotherapy from the record of Surveillance, Epidemiology, and End Results (SEER ) database. About 70% ( n =4034) of the chosen GAC patients were randomly assigned to the training set, and the rest of the included ones ( n =1729) were assigned to the external validation set. A prognostic nomogram was constructed by the training set and the predictive accuracy of it was validated by the validation set.
Results: Based on the outcome of a multivariate analysis of candidate factors, a nomogram was developed that encompassed age at diagnosis, number of regional lymph nodes examined after surgery, number of positive regional lymph nodes , sex , race, grade, derived AJCC stage, summary stage , and radiotherapy status. The C-index (Harrell’s concordance index) of the nomogram model was some larger than that of the traditional seventh AJCC staging system (0.707 vs 0.661). Calibration plots of the constructed nomogram displayed that the probability of DSS commendably accord with the survival rate. Integrated discrimination improvement (IDI) revealed obvious increase and categorical net reclassification improvement (NRI) showed visible enhancement. IDI for 3-, 5- and 10- year DSS were 0.058, 0.059 and 0.058, respectively ( P >0.05), and NRI for 3-, 5- and 10- year DSS were 0.380 (95% CI=0.316–0.470), 0.407 (95% CI=0.350–0.505), and 0.413 (95% CI=0.336–0.519), respectively. Decision curve analysis (DCA) proved that the constructed nomogram was preferable to the AJCC staging system.
Conclusion: The constructed nomogram supplies more credible DSS predictions for GAC patients who receive surgery and chemotherapy in the general population. According to validation, the new nomogram will be beneficial in facilitating individualized survival predictions and useful when performing clinical decision-making for GAC patients who receive surgery and chemotherapy.
Newborn Mortality And Its Associated Factors Among Neonates Admitted At Public Hospitals In Afar Region; A Health Facility Based Study
Authors: woday abay , Mekuria Yohannes , Denis Christine St 
Published: December 2019

Abstract

Background: Neonatal mortality is a public health issue in developing countries, such as Ethiopia. Unfortunately, the issue is noticeably under-reported and underestimated, so the true gravity of the situation cannot be acknowledged. Subsequently, Afar in Ethiopia contributes the largest burden of under-five mortality when compared to other regions in the country. Regrettably, there is no current information to the rates and predictors of neonatal mortality for the region even for the health facilities. Thus, this study aims to assess neonatal mortality and associated factors in pastoral region, Afar region.
Methods: A health facility-based retrospective cross-sectional study was conducted on 403 neonates admitted to the neonatal intensive care unit (NICU) from May 1st 2015 - May 2nd 2019. Medical records were reviewed and audited for both mothers and neonates to collect data using a standardized data extraction checklist. The medical records were selected using a systematic sampling technique. Binary logistic regression with odds ratio and 95% Confidence interval was calculated to assess the association between neonatal mortality and associated factors. Finally, the statistical significance level was declared at a p-value <0.05.
Results: In this study, 391 medical records of neonates were included with the data complete rate of 97.02%. The prevalence of neonatal mortality was 14.6% (95% CI 11.0%-18.4%) with mortality rate of 35.5 per 1000 live births. A multivariable logistic regression showed that the lack of antenatal care (ANC) follow up (AOR = 5.92; 95%CI 2.34, 14.97: P<0.001), giving birth through cesarean section (AOR=3.52; 95%CI 1.22, 10.12: P<0.05), giving birth through assisted delivery (AOR=3.28 (1.14, 9.46): P<0.05), having a temperature less than 36.5oC within the first hour of admission (AOR= 5.89; 95%CI 2.32, 14.94: P<0.001), and perinatal asphyxia (AOR= 6.67; 95%CI 2.35, 18.89: P<0.001) were signiﬁcantly associated with neonatal mortality.
Conclusion: This study revealed that the rate of neonatal mortality is still too high compared to the studies conducted in non-pastoral regions of the nation. Thus, the health facilities should give due attention to improve antenatal care, neonatal resuscitation and follow the standard of care protocol for admitted neonates. Additional community based studies supported with qualitative methods are recommended.
Mobile X-ray outside the Hospital: a review
Authors: Toppenberg Maria Dietz , Christiansen Thomas Erik Møller , Rasmussen Finn , Nielsen Camilla Palmhøj , Damsgaard Else Marie 
Published: December 2019

Abstract
Background For several years mobile X-ray equipment has been used in intensive care units, when transportation to the radiology department was inadvisable. Now, mobile X-ray examinations are also used outside hospital. The literature describes that fragile patients may benefit from mobile X-ray, but we need to know if it is an evident alternative to hospital-based examination and in what populations. Methods We searched PubMed, Cinahl and Embase for English-, Danish-, Norwegian - and Swedish-language studies, published within the last 10 years about mobile X-ray outside the hospital. We decided that both qualitative and quantitative studies were eligible. Result We included nine studies in this scoping review. The results were divided into four topics : 1. Target population 2. Population health 3 . Experience of care and 4. C ost effectiveness . The conclusions are unclear, as quality of the evidence is low, the study populations are small, and the descriptions of the technology are week. Conclusion Mobile X-ray may be used outside hospital. There seems to be potential benefits to both patients and health care staff. Based on the published studies it is not possible to conclude if mobile X-ray examination is a relevant diagnostic offer and for whom. Further studies are needed to assess the feasibility of use in fragile patients, also regarding staff, relatives and society.
Youth Working in Tobacco Farming: Effects on Smoking Behavior and Association with Health Status
Authors: Alderete Ethel , Livaudais-Toman Jennifer , Kaplan Celia , Gregorich Steven E. , Mejía Raúl , Perez-stable Eliseo J 
Published: December 2019

Abstract
Background Cultivation of tobacco raises concerns about detrimental health and social consequences for youth, but tobacco producing countries only highlight economic benefits. We compared sociodemographic and health-related characteristics of school-age youth who worked and did not work in tobacco farming and assessed the effects on smoking behavior and health at one year.Methods We used existing data collected in the province of Jujuy, Argentina where 3188 youth 13 to 17 years of age from a random middle school sample responded to longitudinal questionnaires in 2005 and 2006. Multivariate logistic regression models predicted association of tobacco farming work with health status and smoking behavior at one year.Results 22.8% of youth in the tobacco growing areas of the province were involved in tobacco farming. The mean age of initiation to tobacco farming was 12.6 years. Youth working in farming had higher rates of fair or poor versus good or excellent self-perceived health (30.3% vs. 19.0%), having a serious injury (48.5% vs. 38.5%), being injured accidentally by someone else (7.5% vs. 4.6%), being assaulted (5.5% vs. 2.6%), and being poisoned by exposure to chemicals (2.5% vs. 0.7%). Youth working in tobacco farming also had higher prevalence of ever (67.9% vs. 55.2%), current (48.0% vs. 32.6%) and established smoking (17.8% vs. 9.9%). In multivariate logistic regression models tobacco farming in 2005 was associated with significant increased reporting of serious injury (OR=1.4; 95%CI 1.1-2.0), accidental injury by someone else (OR=1.5; 95% 1.0-2.1), assault (OR=2.2; 95% CI 1.3-3.8), and poisoning by exposure to chemicals (OR=2.5; 95% CI 1.2-5.4). Tobacco farming in 2005 predicted established smoking one year later (OR=1.5; 95% CI 1.1-2.0).Conclusion Youth who work in tobacco faming face a challenging burden of adversities that increase their vulnerability. Risk assessments should guide public policies to protect underage youth working in tobacco farming. (298 words)
Next-Generation Sequencing Identified Novel Desmoplakin Frame-shift Variant in Patients with Arrhythmogenic Cardiomyopathy
Authors: Lin Xiaoping , Ma Yuankun , Cai Zhejun , Wang Qiyuan , Wang Lihua , Huo Zhaoxia , Hu Dan , Wang Jian'an , Xiang Meixiang 
Published: December 2019

Abstract
Background: Arrhythmogenic cardiomyopathy (AC) is one of the leading causes for sudden cardiac death (SCD). Recent studies have identified mutations in cardiac desmosomes as key players in the pathogenesis of AC. However, the specific etiology in individual families remains largely unknown. Methods: A 4-generation family presenting with syncope, lethal ventricular arrhythmia and SCD was recruited. Targeted next generation sequencing (NGS) was performed and validated by Sanger sequencing. Plasmids containing the mutation and wild type (WT) were constructed, real-time PCR, western-blot and immunofluorescence were performed to detect the functional change due to the mutation. Results: The proband, a 56-year-old female, presented with recurrent palpitations and syncope. An ICD was implanted due to her family history of SCD/ aborted SCD. NGS revealed a novel heterozygous frame-shift variant (c.832delG) in Desmoplakin (DSP) among 5 family members. The variant led to frame-shift and premature termination, producing a truncated protein. Cardiac magnetic resonance (CMR) of the family members carrying the same variant shown myocardium thinning and fatty infiltration in the right ventricular, positive bi-ventricular late gadolinium enhancement and severe RV dysfunction, fulfilling the diagnostic criteria of AC. HEK293T cells transfected with mutant expressed truncated DSP mRNA and protein, upregulation of nuclear junction plakoglobin (JUP) and downregulation of β-catenin, when compared with WT. Conclusion: We infer that the novel c.832delG variant in DSP was associated with AC in this family, likely through Wnt/β-catenin signaling pathway.
Management of stretched scar– induced secondary strabismus
Authors: Farid Mohamed F , Awwad Mohamed A , Mahmoud Mohamed R 
Published: December 2019

Abstract
BACKGROUND: To determine characteristics and management of consecutive or recurrent strabismus secondary to stretched scar. METHODS: This is a retrospective review of all patients diagnosed with late secondary consecutive or recurrent strabismus due to stretched scar from 2012 to 2017. The diagnosis of stretched scar was made in any case of late (≥ 1 month) consecutive or recurrent strabismus associated with underaction of the previously operated muscle. The diagnosis was confirmed intraoperatively by negative forced duction test and the characteristic appearance of the scar tissue. Surgical correction involved excision of the scar tissue with muscle re-attachment to the sclera using non-absorbable sutures. Study parameters include improvement in secondary deviations, degree of muscle underaction and diplopia. RESULTS: 21 consecutive and 6 recurrent cases of stretched scar –induced strabismus were identified and all cases were associated with variable degrees of limited ocular duction. After surgical correction of the stretched scar, consecutive deviations in the form of consecutive esotropia and exotropia were corrected by means of 26.1PD and 65.6PD while recurrent deviations in the form recurrent exotropia and recurrent hypertropia were corrected by means of 34.3PD and 11PD respectively with significant improvement of limited ocular ductions. 21 patients had diplopia at presentation and all were improved after surgery. CONCLUSION: management of stretched scar –induced secondary strabismus by excision of the stretched scar and muscle fixation to the sclera using non-absorbable sutures significantly corrects secondary deviations and improves limitation of ocular duction.
Effect of gga-miR-155 on Cell Proliferation, Apoptosis and invasion of Marek’s disease Virus (MDV) transformed cell line MSB1 by targeting RORA
Authors: Ding Ke , Yu Zuhua , Yu Chuan , Jia Yanyan , He Lei , Liao Chengshui , Li Jing , Zhang Chunjie , Li Yingju , Wu Tingcai , Cheng Xiangchao , Zhou Zhiyu , Yu Zuling 
Published: December 2019

Abstract
Background Marek's disease (MD) is an avian lymphoproliferative neoplasm caused by the oncogenic Marek's disease virus (MDV). MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in most cancers. The gga-miR-155 is downregulated in the MDV-infected chicken tissues or lymphocyte lines, although its exact role in tumorigenesis remains unclear. The aim of this study was to analyze the effects of gga-miR-155 on the proliferation, apoptosis and invasiveness of an MDV-transformed lymphocyte line MSB1 and elucidate the underlying mechanisms.Results The expression level of gga-miR-155 was manipulated in MSB1 cells using specific mimics and inhibitors. While overexpression of gga-miR-155 increased proliferation, decreased the proportion of G1 phase cells relative to that in S and G2 phases, reduced apoptosis rates and increased invasiveness. However, its downregulation had the opposite effects. Furthermore, gga-miR-155 directly targeted the RORA gene and downregulated its expression in the MSB1 cells.Conclusion The gga-miR-155 promotes the proliferation and invasiveness of the MDV-transformed lymphocyte line MSB1 and inhibits apoptosis by targeting the RORA gene.
Mitochondrial DNA copy number in cervical exfoliated cells and risk of cervical cancer among HPV-positive women
Authors: Sun Wei , Qin Xueyun , Zhou Jing , Xu Mingjing , Lyu Zhangyan , Li Xin , Zhang Kai , Dai Min , Li Ni , Hang Dong 
Published: December 2019

Abstract
Background
Although human papillomavirus (HPV) infection has been recognized as the major cause of cervical cancer, only a minority of HPV-infected women develop this malignancy. An increasing amount of evidence suggests that alterations of mitochondrial DNA copy number (mtCN) may c ontribute to carcinogenesis. However, the relationship between mtCN and cervical cancer remains unknown.
Methods
In this case-control study, we included 591 cervical cancer cases and 373 cancer-free controls, all of whom were infected with high-risk HPV. Relative mtCN in cervical cancer exfoliated cells was measured by qRT-PCR assay s , and logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Interaction between mtCN and HPV types was assessed by using the Wald test in logistic regression models.
Results
HPV16, 18, 52, and 58 were the most common types in both case and control groups. Median mtCN in cases was significantly higher than that in controls ( P = 0.03). After adjustment for age and HPV types , the highest quartile of mtCN was associated with increased odds of having cervical cancer (OR = 1.77, 95% CI = 1.19, 2.62; P < 0.01), as compared to the lowest quartile. A dose-response effect of mtCN on cervical cancer was also observed ( P trend < 0.001). The interaction between mtCN and HPV types was statistically nonsignificant.
Conclusions
Increased mtCN in cervical exfoliated cells is associated with cervical cancer after HPV infection, suggesting a potential role of mtCN in cervical carcinogenesis.
Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice
Authors: Ye Xin-chun , Hao Qi , Ma Wei-jing , Zhao Qiu-chen , Wang Wei-wei , Yin Han-han , Zhang Tao , Wang Miao , Zan Kun , Yang Xin-xin , Zhang Zuo-hui , Shi Hong-juan , Zu Jie , Raza Hafiz Khuram , Zhang Xue-ling , Geng De-qin , Hu Jin-xia , Cui Gui-yun 
Published: December 2019

Abstract
Dendritic cell-associated C-type lectin-1 (Dectin-1) receptor has been reported to be involved in neuroinflammation in Alzheimer's disease and traumatic brain injury. The present study was designed to investigate the role of Dectin-1 and its downstream target spleen tyrosine kinase (Syk) in early brain injury after ischemic stroke using a focal cortex ischemic stroke model. Adult male C57BL/6J mice were subjected to a cerebral focal ischemia model of ischemic stroke. The neurological score, adhesive removal test and foot-fault test were evaluated on days 1, 3, 5 and 7 after ischemic stroke. Dectin-1, Syk, phosphorylated (p)-Syk, tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) expression was analyzed via western blotting in ischemic brain tissue after ischemic stroke and in BV2 microglial cells subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) injury in vitro. The brain infarct volume and Iba1-positive cells were evaluated using Nissl’s and immunofluorescence staining, respectively. The Dectin-1 antagonist laminarin (LAM) and a selective inhibitor of Syk phosphorylation (piceatannol; PIC) were used for the intervention. Dectin-1, Syk, and p-Syk expression was significantly enhanced on days 3, 5 and 7 and peaked on day 3 after ischemic stroke. The Dectin-1 antagonist LAM or Syk inhibitor PIC decreased the number of Iba1-positive cells and TNF-α and iNOS expression, decreased the brain infarct volume and improved neurological functions on day 3 after ischemic stroke. In addition, the in vitro data revealed that Dectin-1, Syk and p-Syk expression was increased following the 3-h OGD and 0, 3 and 6 h of reperfusion in BV2 microglial cells. LAM and PIC also decreased TNF-α and iNOS expression 3 h after OGD/R induction. Dectin-1/Syk signaling plays a crucial role in inflammatory activation after ischemic stroke, and further investigation of Dectin-1/Syk signaling in stroke is warranted.