bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reptiles on the wrong track? Moving beyond traditional estimators with dynamic Brownian Bridge Movement Models
Authors: Silva Inês , Crane Matt , Marshall Benjamin Michael , Strine Colin Thomas 
Published: October 2020

Abstract
Background
Animal movement expressed through home ranges or space-use can offer insights into spatial and habitat requirements. However, different classes of estimation methods are currently instinctively applied to answer home range, space-use or movement-based research questions regardless of their widely varying outputs, directly impacting conclusions. Recent technological advances in animal tracking (GPS and satellite tags), have enabled new methods to quantify animal space-use and movement pathways, but so far have primarily targeted mammal and avian species.

Methods
Most reptile spatial ecology studies only make use of two older home range estimation methods: Minimum Convex Polygons (MCP) and Kernel Density Estimators (KDE), particularly with the Least Squares Cross Validation (LSCV) and reference (href) bandwidth selection algorithms. These methods are frequently applied to answer space-use and movement-based questions. Reptile movement patterns are unique (e.g., low movement frequency, long stop-over periods), prompting investigation into whether newer movement-based methods –such as dynamic Brownian Bridge Movement Models (dBBMMs)– apply to Very High Frequency (VHF) radio-telemetry tracking data. We simulated movement data for three archetypical reptile species: a highly mobile active hunter, an ambush predator with long-distance moves and long-term sheltering periods, and an ambush predator with short-distance moves and short-term sheltering periods. We compared traditionally used estimators, MCP and KDE, with dBBMMs, across eight feasible VHF field sampling regimes for reptiles, varying from one data point every four daylight hours, to once per month.

Results
Although originally designed for GPS tracking studies, dBBMMs outperformed MCPs and KDE href across all tracking regimes in accurately revealing movement pathways, with only KDE LSCV performing comparably at some higher frequency sampling regimes. However, the LSCV algorithm failed to converge with these high-frequency regimes due to high site fidelity, and was unstable across sampling regimes, making its use problematic for species exhibiting long-term sheltering behaviours. We found that dBBMMs minimized the effect of individual variation, maintained low error rates balanced between omission (false negative) and commission (false positive), and performed comparatively well even under low frequency sampling regimes (e.g., once a month).

Conclusions
We recommend dBBMMs as a valuable alternative to MCP and KDE methods for reptile VHF telemetry data, for research questions associated with space-use and movement behaviours within the study period: they work under contemporary tracking protocols and provide more stable estimates. We demonstrate for the first time that dBBMMs can be applied confidently to low-resolution tracking data, while improving comparisons across regimes, individuals, and species.
Hybrid technique of virtual-assisted lung mapping and systemic indocyanine green injection for extended segmentectomy
Authors: Yanagiya Masahiro , Hiyama Noriko , Matsumoto Jun 
Published: October 2020

Abstract
Background
Various approaches have been used to assist and facilitate segmentectomy with favorable oncological outcomes. We describe a hybrid approach comprising virtual-assisted lung mapping (VAL-MAP), which is a preoperative bronchoscopic dye-marking technique, combined with systemic indocyanine green (ICG) injection.

Clinical presentation
An asymptomatic 64-year-old man was referred to our department because of a lung nodule detected during his annual medical checkup. The chest computed-tomography image revealed a 16-mm, partly solid, ground-glass nodule in the left segment 4. Because the nodule was hardly palpable and deeply located between the left upper division segment and the left lingular segment, we performed VAL-MAP to facilitate extended left lingulectomy. Five dye markings were undertaken preoperatively. Surgery to remove the nodule was then conducted via complete three-port video-assisted thoracic surgery. The VAL-MAP markings were easily identified intraoperatively and helped locate the nodule. The intersegmental plane was identified by the ICG injection. The resection line was determined based on the intersegmental plane identified by the ICG injection and the site of the nodule suggested by the VAL-MAP markings. Following the resection line, we thoracoscopically achieved extended lingulectomy with sufficient surgical margins. The patient was discharged with no complications. The pathological diagnosis was adenocarcinoma in situ.

Conclusion
The hybrid technique of VAL-MAP and systemic ICG injection can be useful for accomplishing successful extended segmentectomy.
Microbacterium sp. MRS-1, a potential bacterium for cobalt reduction and synthesis of less/non-toxic cobalt oxide nanoparticles (Co3O4)
Authors: Sundararaju Sathyavathi , Arumugam Manjula , Bhuyar Prakash 
Published: October 2020

Abstract
Background
Detoxification of heavy metal pollutants in wastewater has become a serious problem to surrounding environment. This research was conducted to utilize a potential heavy metal-resistant bacterium for the remediation of cobalt metal and simultaneous synthesis of cobalt oxide nanoparticles in the form of powder for various industrial applications. Metal oxide nanoparticles have great applications in electrochemical devices such as supercapacitors, biosensors, and batteries.

Method
A heavy metal-resistant bacterium Microbacterium sp. MRS-1 isolated from electroplating industrial effluent reduced cobalt ions from an initial concentration of 200 mg/L to 26 mg/L were analyzed by atomic absorption spectroscopy. Instrumental analysis of bacterially synthesized Co3O4 has been characterized. Cytotoxicity of synthesized nanoparticles was assessed by MTT assay.

Results
Microbacterium sp. MRS-1 isolated from electroplating industrial effluent was found to be suitable for cobalt oxide nanoparticles as it showed tolerance towards high concentration of metal. The nutrient broth containing metal solution and Microbacterium sp. MRS-1 showed color change from light pink to dark pink indicated the formation of extracellular nanoparticles. It also converted soluble cobalt salts into less soluble cobalt oxide nanoparticles outside the cell which allows easy recovery of nanoparticles without the destruction of cells and simultaneous detoxification of toxic metal ions. Electron microscopic imaging verified that nanoparticles were predominantly surrounding the bacterial cells and SEM imaging revealed that the produced particles were in the range of 10–100 nm in size. XRD spectrum exhibited 2θ values were corresponding to cubic face-centered cobalt oxide (Co3O4) nanoparticles.

Conclusion
The present study investigated new prospective for eco-friendly detoxification of toxic heavy metal Co from metal-polluted sites and the production of cobalt oxide nanoparticles in powder form for clinical and other industrial applications.
The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt
Authors: Rashad Nearmeen M. , Amer Marwa G. , Reda Ashour Waleed M. , Hassanin Hassan M. 
Published: October 2020

AbstractBackgroundMultiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with varied clinical features. Disease-modifying drugs (DMDs) of MS associated with different types of thyroiditis. In this cross-sectional study, we aimed to assess the prevalence of thyroid dysfunction in MS and to investigate the association between DMDs and the risk of thyroiditis in MS. A cross-sectional study included 100 patients with relapsing-remitting multiple sclerosis (RRMS) in relapse, and the diagnosed was according to revised McDonald’s criteria 2010.ResultsOur results revealed that the prevalence of thyroiditis was 40%; autoimmune (34%) and infective (6%) among patients with RRMS in relapse and cerebellar symptoms were significantly higher in patients with thyroiditis compared to patients without thyroiditis. Regarding the association between DMDs and thyroiditis, the prevalence of patients treated with interferon-beta-1b was higher in MS patients with thyroiditis compared to MS patients without thyroiditis. However, the prevalence of patients treated with interferon-beta-1a was lower in MS patients with thyroiditis compared to MS patients without thyroiditis. In addition, we found CMV infection was more common in patients treated by interferon beta-1b and candida infection was common in patients treated by fingolimod.ConclusionsThyroiditis is commonly observed in patients with RRMS in relapse and higher prevalence of patients treated with interferon-beta-1b which is commonly associated with thyroiditis and CMV infection; however, candida thyroid infection was common in MS patients treated by fingolimod.
Elicitation of Health Utilities in Oncology in the Kingdom of Saudi Arabia
Authors: Iskedjian Michael , De Vol Edward , Elshenawy Mahmoud , Bazarbashi Shouki 
Published: October 2020

PURPOSEHealth utilities (HUs) are quantitative measures of quality of life that are used to derive outcomes such as quality-adjusted life years in cost-effectiveness analyses. In the Kingdom of Saudi Arabia, there are no HUs for cancer. This study aimed to generate HU estimates for various health states associated with cancer in the Kingdom of Saudi Arabia.METHODSAdult citizens of the Kingdom of Saudi Arabia, patients with cancer, and patients without cancer were recruited to participate in an online version of the Time Trade-Off (TTO) survey, a direct method that asks participants to indicate the amount of time they are willing to trade off in return for full health. The time horizon was 10 years. Patients were surveyed on their own health state; patients without cancer were presented with a scenario describing stage III colon cancer and were asked to act as proxies.RESULTSMean HU score was 0.398 (n = 398), 0.315 for patients with cancer (n = 199), and 0.482 for patients without cancer (n = 199). Among patients, the largest subgroup with colorectal cancer (n = 105), had a mean HU of 0.296; the subgroup with the lowest mean HU was patients with hepatocellular cancer (n = 3; 0.047), and the subgroup with the highest mean HU was patients with cholangiocarcinoma (n = 5; 0.508). Overall, the initial stage I subgroup (n = 7) had a mean HU of 0.456; initial stage II (n = 25), 0.240; stage II (n = 67), 0.319; and initial stage IV (n = 77), 0.320.CONCLUSIONTo our knowledge, this is the first study of this size to elicit HU scores for cancer in the Kingdom of Saudi Arabia. Patients may have had clinically worse disease than the patients in the scenario that was presented to patients without cancer. Further analyses are warranted for specific types of cancer. These HUs can in turn be applied in cost-utility analyses.
Molecular Drivers of Oncotype DX, Prosigna, EndoPredict, and the Breast Cancer Index: A TransATAC Study
Authors: Buus Richard , Sestak Ivana , Kronenwett Ralf , Ferree Sean , Schnabel Catherine A. , Baehner Frederick L. , Mallon Elizabeth A. , Cuzick Jack , Dowsett Mitch 
Published: October 2020

PURPOSE The Onco type DX Recurrence Score (RS), Prosigna Prediction Analysis of Microarray 50 (PAM50) Risk of Recurrence (ROR), EndoPredict (EP), and Breast Cancer Index (BCI) are used clinically for estimating risk of distant recurrence for patients receiving endocrine therapy. Discordances in estimates occur between them. We aimed to identify the molecular features that drive the tests and lead to these differences. PATIENTS AND METHODS Analyses for RS, ROR, EP, and BCI were conducted by the manufacturers in the TransATAC sample collection that consisted of the tamoxifen or anastrozole arms of the ATAC trial. Estrogen receptor–positive/human epidermal growth factor receptor 2 (HER2)–negative cases without chemotherapy treatment were included in which all four tests were available (n = 785). Clinicopathologic features included in some tests were excluded from the comparisons. Estrogen, proliferation, invasion, and HER2 module scores from RS were used to characterize the respective molecular features. Spearman correlation and analysis of variance tests were applied. RESULTS There were moderate to strong correlations among the four molecular scores (ρ = 0.63-0.74) except for RS versus ROR (ρ = 0.32) and RS versus BCI (ρ = 0.35). RS had strong negative correlation with its estrogen module (ρ = −0.79) and moderate positive correlation with its proliferation module (ρ = 0.36). RS’s proliferation module explained 72.5% of ROR’s variance, while the estrogen module explained only 0.6%. Most of EP’s and BCI’s variation was accounted for by the proliferation module (50.0% and 54.3%, respectively) and much less by the estrogen module (20.2% and 2.7%, respectively). CONCLUSION In contrast to common understanding, RSs are determined more strongly by estrogen-related features and only weakly by proliferation markers. However, the EP, BCI, and particularly ROR scores are determined largely by proliferative features. These relationships help to explain the differences in the prognostic performance of the tests.
Weight Gain After Thyroidectomy: A Systematic Review and Meta-Analysis
Authors: Huynh Christine N , Pearce Janina V , Kang Le , Celi Francesco S 
Published: October 2020

Abstract

Context
Weight gain is a major driver of dissatisfaction and decreased quality of life in patients with hypothyroidism. Data on the changes in body weight following thyroidectomy are conflicting.

Objective
To perform a systematic review of the literature and a meta-analysis of weight changes following total thyroidectomy.

Data Sources
Literature search on PubMed.

Study Selection
Studies in English published between September 1998 and May 2018 reporting post-thyroidectomy weight changes.

Data extraction
Data were reviewed and compared by 3 investigators; discrepancies were resolved by consensus. Meta-analyses were performed using fixed and random effect models. Univariable and multivariable meta-regression models for weight change were implemented against study follow-up, gender, and age. Exploratory subgroup analyses were performed for indication for surgery.

Data Synthesis
Seventeen studies (3164 patients) with 23.8 ± 23.6 months follow-up were included. Severe heterogeneity across studies was observed. Using a random effect model, the estimated overall weight change was a gain of 2.13 kg, 95% confidence interval (CI; 0.95, 3.30). Age was negatively associated with weight change (β = -0.238, P &lt; 0.001). In subgroup analyses, weight gain was more evident in patients undergoing thyroidectomy for hyperthyroidism: 5.19 kg, 95% CI (3.21, 7.17) vs goiter or malignancy 1.55 kg, 95% CI (0.82, 2.27) and 1.30 kg, 95% CI (0.45, 2.15), respectively.

Conclusions
Patients undergoing thyroidectomy experience possible mild weight gain, particularly younger individuals and those with hyperthyroidism as the indication for surgery. Prospective studies directed to assess the pathophysiology of weight gain post-thyroidectomy, and to test novel treatment modalities, are needed to better characterize post-thyroidectomy weight changes.
Inactivation of a Frameshift TSH Receptor Variant Val711Phefs*18 is Due to Acquisition of a Hydrophobic Degron
Authors: Sugisawa Chiho , Ono Makoto , Kashimada Kenichi , Hasegawa Tomonobu , Narumi Satoshi 
Published: October 2020

Abstract

Context
Inactivating variants of thyrotropin (thyroid-stimulating hormone; TSH) receptor (TSHR) cause congenital hypothyroidism. More than 60 such variants have been reported so far, most of which were located in the extracellular or transmembrane domain.

Objective
We report the identification and characterization of a frameshift TSHR variant in the intracytoplasmic C-tail region.

Methods
Sequencing of TSHR was performed in a patient with congenital hypothyroidism. The functionality of the identified variants was assessed by expressing TSHR in HEK293 cells and measuring TSH-dependent activation of the cAMP–response element-luciferase reporter. A series of systematic mutagenesis experiments were performed to characterize the frameshifted amino acid sequence.

Results
The proband was heterozygous for a known TSHR variant (p.Arg519His) and a novel frameshift TSHR variant (p.Val711Phefs*18), which removed 54 C-terminal residues and added a 17–amino acid frameshifted sequence. The loss of function of Val711Phefs*18-TSHR was confirmed in vitro, but the function of Val711*-TSHR was found to be normal. Western blotting showed the low protein expression of Val711Phefs*18-TSHR. Fusion of the frameshift sequence to green fluorescent protein or luciferase induced inactivation of them, indicating that the sequence acted as a degron. A systematic mutagenesis study revealed that the density of hydrophobic residues in the frameshift sequence determined the stability. Eight additional frameshift TSHR variants that covered all possible shifted frames in C-tail were created, and another frameshift variant (Thr748Profs*27) with similar effect was found.

Conclusions
We characterized a naturally occurring frameshift TSHR variant located in C-tail, and provided a unique evidence that hydrophobicity in the C-terminal region of the receptor affects protein stability.
Borders and the Global North Atlantic
Authors: Otaño Gracia Nahir I. 
Published: October 2020

Abstract
The representation of Africa and Iberia within the North Atlantic imaginary tends to highlight similar features—commodity and trade, the pilgrimage routes to Alexandria and Santiago de Compostela, crusading in Africa or Iberia, Africa and Iberia as Muslim territories, and Africa and Iberia as the borderlands of Europe. Although Chaucer’s textual corpus touches on all the above features, this essay traces the ways that Chaucer interrelates the territories of Africa and Iberia with the borders of Europe. Chaucer subscribes to the attitude that Africa, similar to the East and Al-Andalus, was meant for Christian domination and economic looting.
Émile Mâle and Premodern Pleasures
Authors: McCannon Afrodesia 
Published: October 2020

Abstract
For many European nations, the Middle Ages became the site of their national origins. However, in scholarship of the same era, the period has been subject to infantilizing defamation and dismissal, even by those who claimed to be medievalists. Studies of medieval art and literature, discussion of medieval music, historiography about the period, and so on have assessed the Middle Ages as a time of naïveté, superstition, and violence by individuals who were not fully formed. To this day, the term medieval carries the derogatory connotation of “primitive.” This language is strikingly similar to discourse about colonized and other peoples who were contemporary with the researchers of the period. Focusing on a luminary scholar of the Middle Ages, the art historian Émile Mâle, this essay explores the link between the study of the medieval sense of beauty and the discourse concerning the aesthetics of the art of colonized and indigenous peoples to consider a particular dynamic of European identity formation around the turn of the twentieth century. It argues that the medieval self, pushed away by the teleological model of history, pulled in by nationalism, ruptures and leads to recognition of an unstable European identity.
Unsettling Comparisons
Authors: Sweany Erin E. 
Published: October 2020

AbstractWhile many areas of scholarship are already well into critical examinations of their global turns, one area that is not is the study of early medieval medicine. The number of global comparative approaches for this corpus are few and limited in scope, but this is an ideal time to consider the ethics of how scholars deploy comparisons between the medicine of early medieval England and other medicines, particularly those of American Indigenous peoples. This article argues for ethical comparative approaches between medieval medical corpora and the cultures and archives of American Indigenous peoples and for using decolonial and comparative considerations to guide the future of a scholarship whose framework is increasingly global.
Indigenous Futures and Medieval Pasts
Authors: Andrews Tarren , Cleaves Wallace 
Published: October 2020

Abstract
In this interview Bitterroot Salish medievalist Tarren Andrews and Tongva medievalist Wallace Cleaves discuss the past, present, and future of medieval studies. Their conversation focuses on what it means and has meant to be a Native American scholar in the field of medieval studies, their hope and concerns for the Indigenous turn, and what interested them in medieval studies to begin with. Most important, Andrews and Cleaves discuss how their Native communities impact their medieval scholarship.
Very Slow Phase Transition from the Liquid to Mesophase and Phase-Coexistence in the Ionic Liquid [C8mim]BF4
Authors: Watanabe Keisuke , Komai Tomomi 
Published: October 2020

Abstract
The room temperature ionic liquid, 1-methyl-3-octylimidazolium tetrafluoroborate, abbreviated as [C8mim]BF4, has been known as a good glass-former, which can be cooled or heated at normal scanning rates without any phase transition. However, after cooling to 183 K, just below the glass transition temperature, 190 K, followed by heating to 223 K, Tg + 33 K, a novel phase transition from the supercooled liquid to a partially ordered phase was observed by X-ray diffractometry during a slow isothermal annealing at that temperature. The XRD profiles showed that the ordered phase is not crystal, but a smectic-A phase of a bilayer structure as seen in typical lamellar phases of surfactant solutions or lipid polymers. It is remarkable that the liquid phase still remains even after the existence of the ordered SmA phase for more than 90 hours, which is supposed to be the coexistence, or partial ordering, of the liquid and liquid crystalline. This cannot be seen in conventional one-component systems, such as ordinary molecular liquids. The ionic liquid structure is expected to be very stable due to the original mesoscopic order, which is predicted by MD simulation, Raman spectroscopy and neutron scattering.
Bright Solvent Sensor Using an Inverse Opal Structure Containing Melanin-mimicking Polydopamine
Authors: Kohri Michinari , Kobayashi Akari , Okoshi Taku , Shirasawa Hiroki , Hirai Keita , Ujiie Kazuya , Kojima Takashi , Kishikawa Keiki 
Published: October 2020

Abstract
An inverse opal structure was created using artificial melanin particles composed of a polystyrene core and a polydopamine shell as the template. The melanin-mimicking polydopamine that remained inside the inverse opal structure effectively absorbed multiple scattered light, producing bright structural color that was reversibly changed by solvent penetration.