bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting survival in children requiring intensive care after hematopoietic stem cell transplantation. A retrospective single‐center study
Authors: Szmit Zofia , Kośmider‐Żurawska Magdalena , Król Anna , Łobos Monika , Miśkiewicz‐Bujna Justyna , Zielińska Marzena , Kałwak Krzysztof , Mielcarek‐Siedziuk Monika , Salamonowicz‐Bodzioch Małgorzata , Frączkiewicz Jowita , Ussowicz Marek , Owoc‐Lempach Joanna , Gorczyńska Ewa 
Published: June 2020

AbstractAllo‐HSCT is associated with life‐threatening complications. Therefore, a considerable number of patients require admission to a PICU. We evaluated the incidence and outcome of PICU admissions after allo‐HSCT in children, along with the potential factors influencing PICU survival. A retrospective chart review of 668 children who underwent first allo‐HSCT in the Department of Pediatric Hematology/Oncology and BMT in Wrocław during years 2005‐2017, particularly focusing on patients admitted to the PICU within 1‐year post‐HSCT. Fifty‐eight (8.7%) patients required 64 admissions to the PICU. Twenty‐four (41.5%) were discharged, and 34 (58.6%) patients died. Among the discharged patients, 6‐month survival was 66.7%. Compared with survivors, death cases were more likely to have required MV (31/34; 91.2% vs. 16/24; 66.7% P = .049), received more aggressive cardiac support (17/34; 50% vs. 2/24; 8.3% P = .002), and had a lower ANC on the last day of their PICU stay (P = .004). Five patients were successfully treated with NIV and survived longer than 6 months post‐discharge. The intensity of cardiac support and ANC on the last day of PICU treatment was independent factors influencing PICU survival. Children admitted to the PICU after allo‐HSCT have a high mortality rate. Mainly those who needed a more aggressive approach and had a lower ANC on the last day of treatment had a greater risk of death. While requiring MV is associated with decreased PICU survival, early implementation of NIV might be considered.
Serostatus following polio‐containing vaccination before and after liver transplantation
Authors: Funaki Takanori , Fukuda Akinari , Sakamoto Seisuke , Kasahara Mureo , Saitoh Akihiko , Miyairi Isao 
Published: June 2020

AbstractBackgroundThe strategy to eradicate polio is based on preventing infection by immunizing all children until the world is polio‐free. However, data regarding efficacy of polio‐containing vaccination in immunocompromised patients such as LT recipients are limited.MethodsWe conducted an observational study at the largest pediatric transplant center in Japan from January 2011 to January 2015. LT recipients were enrolled after transplantation, and those who had completed the Japanese polio vaccination program were eligible for the study. Patients' demographics were collected from their medical records. Antibody titers against poliovirus serotypes 1‐3 were measured using the neutralization test at the routine follow‐up visits after enrollment. Factors associated with seropositivity against each type of poliovirus were evaluated.ResultsSixty‐four patients who had received the complete polio vaccination series were enrolled in the study. Of these, 37 patients had received all series of polio‐containing vaccination before LT. Median age of the patients was 75 months. Their underlying diseases included the following: 40 (63%) with cholestatic liver diseases and 11 (17%) with metabolic disorders. After a median interval of 43 months after LT, seropositivity rates against poliovirus 1, 2, and 3 were 93.8% (60/64), 92.2% (59/64), and 54.7% (35/64), respectively. Among 32 patients who had received only oral polio vaccine (OPV), seropositivity against poliovirus 3 was particularly low (25.0%). No factors associated with seropositivity against each type of poliovirus were identified.ConclusionsIn the LT recipients, seropositivity for poliovirus 3 was low, suggesting a need for additional inactivated polio‐containing vaccination after LT, especially for patients who had received only OPV.
Synchronous vasomotion of skin microvessels at acupoints on the twelve main meridians of beagle dogs
Authors: Zhang Tao , Liu Chun , Hu Ge , Dong Hong , Mu Xiang 
Published: June 2020

AbstractBackground/purposeSynchronous microvascular vasomotion was detected at acupoints in our previous human study. This present study aimed to characterize the skin microvascular vasomotion at acupoints on the twelve meridians of beagle dogs.Materials and methodsTwo acupoints were selected on each meridian and exactly located at the rosy red spots by an electrochemical color‐appearing method, where the electrical resistance was measured. The skin blood flow at acupoints was recorded by laser Doppler flowmetry (LDF), and microvascular vasomotion was analyzed according to LDF waveforms.ResultsThe skin electrical resistance at acupoints was significantly lower than that at control non‐acupoints. The LDF waveforms at acupoints were sinusoidal, which showed the synchronization of the microvascular vasomotion. The spectral analysis revealed that the vasomotion frequencies at acupoints on the same meridian were identical but not among different meridians, and the frequencies on the twelve main meridians displayed a constant order.ConclusionThe skin microvascular vasomotion is synchronous at acupoints of beagle dogs and has a specific frequency along the meridian, and the electrochemical color‐appearing method is a feasible strategy for the precise and visual location of acupoints. The study provides evidence for the universality of synchronous vasomotion of skin microvessels at acupoints.
Pattern, clinical and demographic profile of inpatient psychiatry referrals in a tertiary care teaching hospital: a descriptive study
Authors: Mudgal Varchasvi , Rastogi Pali , Niranjan Vijay , Razdan Ramghulam 
Published: June 2020

BackgroundConsultation liaison psychiatry (CLP) as a subspecialty is defined as the area of clinical psychiatry that encompasses clinical understanding, teaching and research activities of psychiatrists and allied health professionals in the non-psychiatric divisions of a general hospital. Psychiatric comorbidity of inpatients in tertiary care hospitals is huge. However, the amount of research in India in the field of consultation liaison is strikingly low.AimTo investigate the sociodemographic profile and psychiatric and physical subtypes of illness in patients admitted in other departments and referred to psychiatry department.MethodsThe study population comprised all consecutive inpatients referred for psychiatric consultation from other departments of a multispecialty tertiary care teaching hospital over 3 months. In a semistructured proforma, sociodemographic profile, referring departments, reasons for referral, referral rate, psychiatric diagnosis and physical illness diagnosis were recorded and analysed using descriptive statistics.Results172 patients were included and assessed after referral from various departments, of which 56.4% were male and 43.6% were female. The mean age was about 33.95 years, with majority of the patients in the 21–30 years age group. The referral rate was 1.1%. The maximum referrals were from the medicine department, with abnormal behaviour (26.2%) being the most common reason for referral, followed by alleged suicide attempt or self-harm (24.4%), anxiety (10.5%), substance use (10%) and disorientation (7.6%). The most common psychiatric disorder among patients was depressive disorder (24.4%), followed by substance use disorder (19.7%), schizophrenia and psychotic disorder (9.3%), and stress and trauma-related disorder (8.1%).ConclusionThere are very few psychiatry referrals and an alarmingly low referral rate, given the psychiatric morbidities in the medical setting. Psychiatry training should have more weightage across different medical specialties and liaison activities between psychiatry and other disciplines should be augmented, which can lead to a better understanding of psychiatric symptomatology, early symptom recognition, swift referral and ensuring follow-up, which, in turn, would be key to improving CLP services.
First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers
Authors: Hong David S , Parikh Aparna , Shapiro Geoffrey I , Varga Andrea , Naing Aung , Meric-Bernstam Funda , Ataman Özlem , Reyderman Larisa , Binder Terri A , Ren Min , Liu Mingjie , Dayal Satish , Siu Amy Y , Sachdev Pallavi , Xu Lucy , Bhagawati-Prasad Vijay , Tchakov Ilian , Ooi Chean Eng , Bao Xingfeng , Marabelle Aurelien 
Published: June 2020

BackgroundE7046 is a highly selective, small-molecule antagonist of the E-type prostanoid receptor 4 (EP4) for prostaglandin E2, an immunosuppressive mediator of the tumor immune microenvironment. This first-in-human phase 1 study assessed the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose (MTD) and recommended phase 2 dose of E7046.MethodsThis first-in-human study enrolled 30 patients with advanced tumors of cancer types associated with high levels of myeloid infiltrates. E7046 was administered orally once-daily in sequential escalating dose cohorts (125, 250, 500, and 750 mg) with ≥6 patients per cohort. Tumor assessments were performed every 6 weeks. Paired tumor biopsies and blood samples, before and on treatment, were collected for pharmacokinetic and pharmacodynamic characterization of the treatment.ResultsNo dose-limiting toxicities were observed, and the MTD was not reached. E7046 had an elimination half-life (t1/2) of 12 hours, and drug exposure increased dose-dependently from 125 to 500 mg. Target modulation by E7046 was supported by changes in genes downstream of EP4 with concurrent enhanced antitumoral immune responses. A best response of stable disease (per irRECIST) was reported in 23% of patients treated with E7046 (n=30) (125 mg: n=2; 250 mg: n=2; 750 mg: n=3). Over half (4/7) of the patients with stable disease had treatment duration of 18 weeks or more, and three patients (3/15; 20%) achieved metabolic responses.ConclusionsIn this first-in-human study, E7046 administered orally once daily demonstrated manageable tolerability, immunomodulatory effects, and a best response of stable disease (≥18 weeks) in several heavily pretreated patients with advanced malignancies. The 250 and 500 mg doses are proposed for further development in the combination setting.Trial registration numberNCT02540291.
HDAC9 deficiency promotes tumor progression by decreasing the CD8+dendritic cell infiltration of the tumor microenvironment
Authors: Ning Yongling , Ding Jun , Sun Xiao , Xie Yewen , Su Mingming , Ma Chenglong , Pan Jie , Chen Jie , Jiang Hua , Qi Chunjian 
Published: June 2020

BackgroundThe tumor microenvironment (TME) contains a variety of immune cells, which play critical roles during the multistep development of tumors. Histone deacetylase 9 (HDAC9) has been reported to have either proinflammatory or anti-inflammatory effects, depending on the immune environment. In this study, we investigated whether HDAC9 in the tumor stroma regulated inflammation and antitumor immunity.MethodsHdac9knockout mice were generated to analyze the HDAC9-associated inflammation and tumor progression. Immune cells and cytokines in TME or draining lymph nodes were quantified by flow cytometry and quantitative reverse transcription-PCR. The antigen presentation and CD8+T cell priming by tumor-infiltrating dendritic cells (DCs) were evaluated in vitro and in vivo. HDAC9-associated inflammation was investigated in a mouse model with dextran sulfate sodium–induced colitis. Correlation of HDAC9 with CD8+expression was assessed in tissue sections from patients with non-small cell lung cancer.ResultsHDAC9 deficiency promoted tumor progression by decreasing the CD8+DC infiltration of the TME. Compared with wild-type mice, the tumor-infiltrating DCs ofHdac9-/-mice displayed impaired cross-presentation of tumor antigens and cross-priming of CD8+T cells. Moreover, HDAC9 expression was significantly positively correlated with CD8+cell counts in human lung cancer stroma samples.ConclusionsHDAC9 deficiency decreased inflammation and promoted tumor progression by decreasing CD8+DC infiltration of the TME. HDAC9 expression in the tumor stroma may represent a promising biomarker to predict the therapeutic responses of patients receiving CD8+T cell-dependent immune treatment regimens.
Predicative Adverbs: Evidence from Polish
Authors: Patejuk Agnieszka , Przepiórkowski Adam 
Published: June 2020

AbstractThis squib argues that adverbs can act as primary predicates. In Polish, a relatively large class of adverbs are frequently used in predicative constructions when the subject of predication is an InfP (infinitival phrase) or a CP referring to abstract objects: event kinds or facts. This requirement of a purely verbal rather than nominal subject of predication is the main difference between predicative adverbs and predicative adjectives, explaining contrasts between their syntactic behavior in extraction and coordination. Predicative adverbs usually express attitudes toward event kinds or facts and often combine with dative experiencers; in the case of InfP subjects, dative experiencers obligatorily control the subject.
Blood and Chuser across Research Paradigms: Constitutive Links in Mapping Biomedical Cancer onto Tibetan Medical Nosology
Authors: Tidwell Tawni 
Published: June 2020

Abstract
Collaborative research on Tibetan medicine for conditions difficult to treat by Euroamerican biomedicine, such as many intractable types of cancer, has developed in recent years due to treatment outcomes and growing patient interest. In these collaborations, more nuanced analyses of how one medical tradition’s etiology maps onto the other are required for productive dialogue and sophisticated research methodologies. Building on earlier work that provides the initial etiologic and diagnostic mapping of biomedical cancer onto Tibetan medical nosology, this article develops a further analytical dimension by describing the specific etiologic role of blood (Tib. khrag) and chuser (Tib. chu ser), as well as their specific ontological characterizations in Sowa Rigpa more generally. The Four Treatises and its commentaries elucidate a unique perspective on these substances as implemented in clinical praxis. This analysis furthers work to disentangle contemporary Tibetan medical and biomedical paradigms by highlighting therapeutic and investigative distinctions for cancer and research collaborations more broadly.
Porous Religious Economies and the Problem of Regulating Religious Marketplaces
Authors: Woods Orlando 
Published: June 2020

Abstract
This paper reframes the theory of religious economy by developing an understanding of the effects of transnational religious influence on religious marketplaces. In doing so, it highlights the need to rethink the role of regulation in shaping the ways in which religious marketplaces operate. By reinterpreting regulation as the ability of the state to control the extent to which religious groups are able to access resources, it argues that transnational religious networks can enable access to extraneous resources, which, in turn, can enable religious groups to subvert the regulatory prescriptions of the state. Transnational religious influences therefore highlight the porosity of religious economies and the problem of regulating religious marketplaces. Qualitative data are used to demonstrate how Singapore-based churches create and strengthen transnational religious networks with their counterparts in China. These networks enable religious groups to operate with a degree of independence and to overcome regulatory restrictions on (and other limitations to) religious praxis.
The relationship between fiscal decentralization and trust in government: evidence from the South Korean case
Authors: Kim Soojin , Lee Yunsoo , Kim Taehee 
Published: June 2020

To date, many developing countries have continued to implement fiscally decentralized governance systems to respond to the diversified needs of local residents more effectively and to better act in line with the public interest. However, little is known about the fiscal decentralization–trust link. Focusing empirically on the South Korean case, this study examines how financially decentralized governance might increase government trustworthiness not just at the national level, but also at the local level. The results of multilevel regression and panel data analyses partly confirm the results of pro-fiscal decentralization studies in that the growth of local fiscal autonomy is positively and significantly related to public trust in government. Specifically, we find that as fiscal decentralization improves, levels of trust in local government also rise. In addition, our findings show that in terms of having higher levels of public trust in government, the impact of revenue decentralization tends to be greater than that of expenditure decentralization. This evidence implies that allowing local governments to have their own revenue sources rather than expenditure autonomy can be a way to better respond to people’s needs in the long run. Points for practitioners First, as fiscal decentralization improves, levels of trust in local government also rise. Second, allowing local governments to have their own revenue sources rather than expenditure autonomy can be a way to better respond to people’s needs in the long run. Third, government policies should aim to provide benefits to citizens for their own sake, such as by exercising effective delivery or improving the quality of public services and programs that are likely to be viewed positively by constituents. This could encourage citizens to engage with the current public-sector spheres in ways that affect their confidence and expectations of government policies and bureaucrats in a positive manner.
Association of urinary incontinence and depression or anxiety: a meta-analysis
Authors: Cheng Shulin , Lin Dong , Hu Tinghui , Cao Liang , Liao Hai , Mou Xiaoxi , Zhang Qiang , Liu Junbo , Wu Tao 
Published: June 2020

Objective We explored the relationship between urinary incontinence (UI) and depression or anxiety. Methods We searched the Cochrane Library, Embase, and PubMed for articles on the association between depression, anxiety, and UI. We calculated pooled 95% confidence intervals (CIs) and odds ratios (ORs). Results Twelve articles (31,462 participants) were included. The UI group had significantly higher depression and anxiety levels than the non-UI group (OR = 1.73, 95%CI: 1.64–1.82, I2 = 75.5%). In subgroup analysis, depression and anxiety were significantly higher in participants with UI than in those without UI (OR = 1.95, 95%CI: 1.82–2.10, I2 = 64.3% and OR = 1.54, 95%CI: 1.43–1.65, I2 = 59.2%, respectively).  In subgroup analysis by age, participants with UI had significantly higher depression and anxiety, regardless of age, than the non-UI group (OR = 1.59, 95%CI: 1.29–1.95, I2 = 59.1% and OR = 1.98, 95%CI: 1.62–2.43, I2 = 75.5%, respectively). Conclusion Patients with UI had significantly higher depression and anxiety levels than those without UI. Depression and anxiety were higher in patients with UI than in those without UI, regardless of age. Larger sample sizes and more high-quality studies are needed to validate our findings.
Maximum Bridging Suture Tension Provides Better Clinical Outcomes in Transosseous-Equivalent Rotator Cuff Repair: A Clinical, Prospective Randomized Comparative Study
Authors: Oh Joo Han , Park Ji Soon , Rhee Sung-Min , Park Joo Hyun 
Published: June 2020

Background: Some studies reporting clinical outcomes after transosseous-equivalent (TOE) repair have attributed type II rotator cuff failure to excessive bridging suture tension, as it can cause overloading on the medial row. In a previous biomechanical cadaveric study, increasing bridging suture tension over 90 N did not improve the contact area and ultimate failure load of the TOE construct, despite increasing the contact force and contact pressure. Purpose: To compare the clinical outcomes of different bridging suture tensions after TOE rotator cuff repair based on the results of a previous biomechanical study. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: A total of 78 patients who underwent arthroscopic rotator cuff repair for medium- to large-sized tears were prospectively enrolled and randomly divided into 2 groups according to the applied bridging suture tension: optimum tension group (96.3 ± 4.9 N) and maximum tension group (199.0 ± 20.3 N). Bridging suture tension was measured with a customized tensiometer, as used in the previous biomechanical study. The functional outcome was measured at the final follow-up (27.4 ± 5.9 months [range, 24-45 months]) using the visual analog scale for pain, American Shoulder and Elbow Surgeons score, Simple Shoulder Test, and Constant score, and the anatomic outcome was evaluated using magnetic resonance imaging or ultrasonography at least 12 months after surgery. Results: Overall, 64 patients (32 in each group) were analyzed. The functional outcomes improved significantly compared with preoperative values (all P < .05) but did not show significant differences between the 2 groups (all P > .05). Regarding the anatomic outcomes, the maximum tension group (n = 1; 3.1%) had a significantly lower healing failure rate than the optimum tension group (n = 9; 28.1%) ( P = .013). One patient in the maximum tension group had a type II failure. Conclusion: Maximum bridging suture tension in TOE repair for medium- to large-sized rotator cuff tears provided better anatomic healing with less risk of medial rotator cuff failure, which differs from the results of a previous time-zero biomechanical study.
Health Communication and the Arts in the United States: A Scoping Review
Authors: Sonke Jill , Sams Kelley , Morgan-Daniel Jane , Schaefer Nancy , Pesata Virginia , Golden Tasha , Stuckey Heather 
Published: June 2020

Objectives: Guided by the hypothesis that the arts can play a role in changing attitudes, beliefs, and health behaviors, the objectives of the study were to (1) overview artistic practices, interventions, and research being conducted at the intersection of the arts and health communication and (2) identify desired and observed outcomes and variables measured in these studies. Data Source: The search strategy was developed iteratively with 2 health science librarians and conducted using 8 databases (Applied Social Sciences Index and Abstracts, Art and Architecture Source, CINAHL, Communication and Mass Media Complete, ERIC, PsycINFO, PubMed, and Web of Science) and hand searching. Articles included were published between 2014 and 2018. Study Inclusion and Exclusion Criteria: Inclusion criteria include US nonclinical setting and use of the arts (broadly defined) to change health knowledge, beliefs, behaviors, or awareness. Any articles not meeting inclusion criteria were excluded. Data Extraction: Covidence’s data extraction tool exported to MS Excel. Data Synthesis: This final set of results was analyzed and synthesized by research design, population, sample size, health issue, purpose, variables measured, and findings. Results: In all, 78 articles met inclusion criteria. Number of participants ranged from 4 to 2140 (mean = 179); 61 (78.2%) outcome studies, including 8 experimental studies; 17 (21.79%) formative research or reports. Many different health topics were addressed and different art forms used. Conclusion: The arts can help build knowledge and awareness of health issues. The authors highlight the need to build an evidence base for arts and public health.