bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEALTH PERSONALITY, HEALTH ACTIVATION, AND GENERAL HEALTH
Authors: Cone Nicholas , Jasper Angelica , Martin Peter 
Published: November 2019

Abstract
The purpose of this investigation was to examine associations between health personality and health activation as predictors of general health. Participants from the study included 3907 individuals 65 years of age and older from AARP® Medicare Supplement Plans insured by UnitedHealthcare Insurance Company. The participants completed a survey including the Health Personality Assessment, the Consumer Health Activation Index, and a single-item assessment of self-rated health. Structural equation modeling determined how health personality predicted health activation, and health activation in turn predicted general health. The hypothesized model fit without direct paths from health personality to general health was not optimal. In a second step, we added direct paths from health openness, health neuroticism, and health conscientiousness to general health. The final model fit was then excellent, x2 (df=2) = 18.26, p &lt; .01, RMSEA = .05, CFI = .99. Health neuroticism and health openness were negatively related to health activation, which indicated participants with high health neuroticism and health openness scores were less health activated. Conversely, higher health agreeableness and conscientiousness were associated with more activation. Pathways from health personality via health activation to general health were tested for mediation. Health activation significantly mediated relationships between health neuroticism, health openness, health agreeableness and health conscientiousness to general health. These findings support health activation accounting for some of the associations between health personality and general health. Health neuroticism, health openness, health agreeableness, and health conscientiousness were more closely connected to health activation than health extraversion.
HYPERTENSION DOES NOT CONTRIBUTE TO MICROBLEEDS ONSET IN FEMALE EFAD MICE
Authors: Cacciottolo Mafalda , Morgan Todd E , Finch Caleb E 
Published: November 2019

Abstract
Cerebral microbleeds (MBs) contribute to pre-clinical cognitive decline and are an additional clinical burden in Alzheimer Disease (AD). Hypertension is associated with MBs, with nearly 2-fold higher likelihood for MBs per SD increment in blood pressure (BP). We investigated the possible role of age-related hypertension in the EFAD mouse model (transgenic for carrying familial AD mutations and targeted replacement of human APO-E3 or -E4). MBs were detected by Prussian Blue histochemistry. We extended prior findings with observations that MBs arise early in life, by 2 months, and confirmed female excess for ApoE3 and-E4 carriers. Wildtype C57BL/6J mice also accumulated MBs, and a 10-fold lower level and more slowly up to 21mo of age. BP was measured by the tail-cuff method. All mice had BP in the normotensive range, &lt;150 mm Hg, systolic. Longitudinal measurements of blood pressure at ages 2, 4, and 6 months showed few age changes, except for E3FAD females at 6 months (systolic, +20%, p&lt;0.05; diastolic, +33%, p&lt;0.05). A possible decrease in blood pressure was observed in EFAD mice (-33%, p&lt;0.01) compared to C57BL/6J mice. A not statistical trend of increase was observed in older C57BL/6J mice up to 18 mo of age, consistent with previous reports. Older ages are required for complete negation of role of hypertension in the MB model. Ongoing studies will examine mice older than 6 months for potential relations of blood pressure and MB, and in relation to brain amyloid deposits which surrounded MBs in our prior study.
AFFECTIVE NEUROPSYCHIATRIC SYMPTOMS MAY BE EARLY SIGNS OF ALZHEIMER'S DISEASE IN NON-DEMENTED OLDER ADULTS
Authors: Jang Jung Y , Nation Daniel A 
Published: November 2019

Abstract
The current study sought to investigate the association between affective neuropsychiatric symptoms (aNPS: depression, anxiety, apathy, irritability), Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers profiles, and the risk of progression to dementia in non-demented older adults. Participants consisted of 763 individuals with normal cognition (CN) (mean age = 73.73 ± 6.68) and 617 with mild cognitive impairment (MCI) (mean age = 73.19 ± 7.40) at baseline, who were enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Latent class analyses (LCA) identified three subgroups of older adults within CN and MCI, respectively, showing distinct patterns of the neuropsychiatric inventory (NPI) domains. Results indicated that the subgroup with higher probabilities of aNPS had elevated risk of progression to dementia (HR = 3.18, 95% CI [1.70, 5.94] in CN, HR = 1.79, 95% CI [1.01, 3.16] in MCI), adjusting for age, sex, and Apolipoprotein E e4 (APOE4) carrier status. Subgroups did not differ in their profiles of AD CSF biomarkers. Findings suggest that aNPS might be symptoms of secondary disease processes in the brain, lowering the threshold for AD pathophysiology to manifest clinically in CN and MCI. The current study highlights the importance of assessment and interventions for emotional and behavioral symptoms in non-demented older adults.
RECRUITING COMMUNITY-DWELLING LIVE-ALONE PERSONS WITH DEMENTIA: AN EXPLORATION OF FIVE GATEKEEPER DOMAINS
Authors: Girling Laura , Medeiros Kate de 
Published: November 2019

Abstract
Although recruiting persons with dementia into research is challenging enough, finding those who live-alone in the community is even more difficult. Consequently, live-alone persons with dementia are often overlooked and/or deliberately excluded from inquiry despite calls for more inclusive approaches to dementia research. Based on enrollment strategies from an interview-based protocol recruiting 120 live-alone persons with dementia, our National Institute on Aging- funded study identified five domains of gatekeepers imperative to gaining access to community-dwelling, live-alone persons with dementia: 1) housing (e.g., service coordinators), 2) data proprietors (e.g., regulatory specialists), 3) institutional (e.g., review boards), 4) kin (including fictive kin), 5) clinical (e.g., medical providers, clinician practices). In addition, gatekeeper domains are multilayered and serve distinct roles in both facilitating and hindering access to and enrollment of this under-researched vulnerable population. Analysis of our recruitment efforts contribute significant insights into how the dementia research community may engage the various domains of community gatekeepers, providing direction for current and future social science research.
AGE DIFFERENCES IN THE CHARACTERISTICS AND HABITS OF 2019 BIKE WEEK ATTENDEES IN DAYTONA BEACH, FLORIDA
Authors: Wheaton Felicia V , Brown Desmond 
Published: November 2019

Abstract
Older adults are an important demographic group in the tourism sector, particularly in Florida. This study assessed age-group differences in the characteristics and habits of 2019 Daytona Bike Week attendees, as evidence indicates the average age of bike week visitors is rising. Aging Studies and Hospitality undergraduate students at Bethune-Cookman University interviewed 335 participants using Google Forms on their mobile phones. Results from chi-square tests indicate that there were significant differences between younger (20-39 years), middle-aged (40-59 years) and older adults (60+ years) in terms of gender and income, expenditures on accommodations, type of accommodations, nights spent, and first-time attendance. A greater percentage of older bike week attendees were male and higher income, and were less likely to be first-time attendees. Older adults also tended to spend more on accommodation and stayed longer, and were more likely to stay in Air BnBs, rental homes or a second home/condo compared with younger and middle-aged adults, but were less likely to stay in a hotel/motel or with friends/family. No significant differences were found in expenditures on food, alcohol, gas, entertainment or shopping. Findings suggest that older bike week attendees are important contributors to bike week tourism, particularly with respect to accommodations.
THE EFFECT OF LANGUAGE ON PREPARATION FOR OLD AGE: EVIDENCE FROM CROSS-CULTURAL SURVEY AND TWITTER DATA
Authors: Chen Amber Xuqian , Fung Helene H 
Published: November 2019

Abstract
We aimed to further investigate the linguistic-savings hypothesis (Chen, 2013) in the field of aging, which maintains that when languages grammatically divide the future and the present (e.g. English and Czech), speakers tend to behave less future-oriented than those speaking languages that do not mark future tense (e.g. German and Chinese). In the 2018 wave of Aging as Future Project, 2,042 participants from the United States, Germany, Czech Republic, Hong Kong and Taiwan (18-93 year, Mean age= 55.47, 55.61% female) completed online questionnaires. The results supported the hypothesis that people speaking future-less languages tended to perceive the timing of preparation for old age closer to the present in terms of finance, living arrangement, nursing care, and loneliness, they also took action earlier and performed more relevant activities. Furthermore, the association between language and preparation timing was more salient in older adults than younger counterparts. And path analysis revealed that time discounting was a significant predictor (P=0.049) for the future-oriented behavior. Hence, speakers of futureless languages will view the future as temporally closer to the present, causing them to discount the future less and prepare for old age actively. Using LIWC 2017, we then analyzed community-level of future orientation with 80 million Tweets across countries and replicated our principal result through that usage of future-oriented languages partly predicted prevalence of health behaviors. The findings indicate that language not only shape people's own future-oriented outcomes, through decreasing time discounting, but also influence population health as a whole.
THE ASSOCIATIONS BETWEEN PERSONAL EVENTS AND COGNITIVE FUNCTION: DOES GENDER MAKE A DIFFERENCE?
Authors: Hua Yingxiao , Dong Gabriella 
Published: November 2019

Abstract
Recent studies suggested stressful personal events were associated with lower cognitive function and that men and women have different responses to stressful events. There is additionally ample evidence supported gender difference in cognitive function in later age. However, research regarding whether gender would moderate the relationship between personal events and cognitive function are limited. Our data were retrieved from 3,126 US Chinese older adults in Chicago between 2017 to 2019. Personal events were measured by a composite score (range 0-28) of all lifetime events including fire, physical assault, rob, sexual assault, divorce, death, cancer, homeless, imprisonment, false accuse, miscarriage and abortion. Global cognition was constructed by mean of z scores from five cognition tests, covering episodic memory, working memory, executive function and C-MMSE test. Stepwise linear regressions were performed to test the association. After adjusting for social demographic confounders, personal events score was positively associated with global cognition (b=0.018, SE=0.007, p=0.013), and significant interaction term of gender and global cognition was found (b=0.019, SE=0.009, p=0.041). The study found the protective effect of undergoing personal events on cognitive function in an aging population, and it was stronger among women. The findings highlighted the important role of gender in the relationship. Identifying mechanisms underlying this may provide gender-specific information for prevention of cognition decline among older adults. Future studies could explore gender difference in short-term and chronic stressful personal events, respectively, to improve understandings of how traumatic personal events impact cognitive function.
BIOLOGICAL MARKERS OF AGING: CHRONIC STRESS AND COGNITIVE IMPAIRMENT IN RESPONDERS FROM THE WORLD TRADE CENTER
Authors: Diminich Erica D , Clouston Sean , Scott Stacey B , Palekar Nikhil , santiago Erica D , Bromet Evelyn , Luft Benjamin 
Published: November 2019

Abstract
Post-traumatic Stress Disorder (PTSD) is a stress related syndrome. Chronic PTSD has increasingly been associated with poor health outcomes, neurodegeneration and risk for cognitive impairment (CI). However, the biological mechanisms underlying the development and maintenance of symptoms and potential associations in accelerating aging are not well understood. The aim of this study was to evaluate whether specific biomarkers influence functional limitations and cognitive impairment in rescue and recovery workers (i.e. responders) from the attacks on the World Trade Center (WTC) in New York. Plasma biomarkers were collected during annual health and wellness visits at the WTC responder clinic between 2012 and 2014. Short Physical Performance Battery (SPPB) and clinical data were examined with prospective PTSD symptom scores collected during participant’s initial enrollment into the parent study as early as 2002. We examined the relationship between cardiovascular (Diastolic Blood Pressure, Systolic Blood Pressure, pulse rate), metabolic (Total Cholesterol, HDL cholesterol, Triglycerides, Glucose, Body Mass Index) and inflammation markers (Albumin, White Blood Count) with Post-traumatic Stress Disorder (PTSD), cognitive functioning (Montreal Cognitive Assessment) and frailty (Short Physical Performance Battery) in responders from the World Trade Center (WTC). We first examined correlations between biomarkers, PTSD symptom severity, PTSD dimensions, cognitive functioning and frailty. We then conducted multivariate regression analyses. In models adjusted for potential confounders, among N=1,045 responders, elevated PTSD was strongly associated with increased frailty, cardiovascular dysregulation and mild cognitive impairment. Current work is ongoing to identify trajectories of change in cognition with frailty and biological factors.
WHAT FAMILY CAREGIVERS THINK AND FEEL WHEN PROXY ASSESSING FROM DIFFERENT PERSPECTIVES
Authors: Egan Patricia 
Published: November 2019

Abstract
Dementia family caregivers are routinely enlisted as proxy assessors of care recipient quality of life (QOL). Proxy assessment is not ideal because proxy assessments differ systematically from self-assessments and the assessment process can elicit negative affect from family caregivers. Prompting adoption of the care recipient’s perspective can enhance assessment congruence and may improve the emotional experience for assessors. This study explored family caregivers’ cognitive and affective experiences during QOL proxy assessments made from both their own and care recipients’ perspectives. Thirty-six dementia family caregivers were recruited from senior service agencies. Subjects completed the Quality of Life-Alzheimer Disease (QOL-AD), Caregiver Version using standard instructions to assess QOL across thirteen domains of their care recipient’s life without specifying the perspective to be used. Subjects were next asked to repeat the QOL-AD with instructions to adopt the perspective of their care recipient, as they imagined it to be. Subjects were then interviewed about what they thought and felt during each proxy assessment experience. Content analysis indicated that spontaneous perspective shifts and response shifts frequently occurred. Most subjects (91.7%) reported changed thinking for one or more QOL-AD domains when they were prompted to switch perspectives. Over half (61.12%) reported changed affect when switching perspectives and 90.9% of those experiencing changed affect reported affective improvement. Little or no affective change was reported by 38.89%. Findings suggest awareness of perspective can enhance clinical interpretation of proxy assessed QOL and can inform clinical response to dementia family caregivers who experience negative emotions while proxy reporting QOL.
OASIS STUDY: ACTIVITY PATTERNS OF OLDER ADULTS LIVING IN FIVE AGING IN PLACE COMMUNITIES
Authors: DePaul Vincent , Donnelly Catherine , Parniak Simone , Collaborative Oasis Study 
Published: November 2019

Abstract
Background: The Oasis program is a model of aging-in-place that targets social connectedness, physical activity and nutritional wellness through member-driven programming. Oasis, first established in an apartment building in Kingston Ontario, has recently been expanded to 6 new communities across Ontario in a participatory action research study. The purpose of this poster is to describe the physical activity patterns of five unique Oasis communities (Original and 4 new) and explore the impact of personal, environmental, and Oasis program characteristics on these patterns. Methods: Participants were recruited from Oasis communities in 3 market-priced apartiments, 1 subsidized apartment, and 1 mobile-home park. Participants wore the ActivPAL3 activity monitor for 7 days. Mobility was measured using the Timed Up and Go. Programming was described by type (e.g. social, exercise, nutrition), frequency, and timing of programming. Results: Participants included 70 older adults aged 79.8(min 62, max 97), community mean age ranged from 66.2 – 83.5 years. TUG score 11.6(SD 4.9) (community range 10.5 to 13.7 s). Average daily step count was 5800(SD 2835) steps, with communities ranging from 4685 to 6472 steps/day. An average of 604(community range 236 – 1056) of steps were taken at a healthy pace(100 steps/min). Only 27% of participants took the recommended 7000 steps/day (with community rates ranging from 9.5% to 37.5%). Conclusions: Older adults within these aging in place communities demonstrated low to moderate levels of physical activity, with activity patterns differing across communities. Impact of community make up and characteristics on activity patterns will be presented.
PERCEIVED SOCIAL ISOLATION AND HEALTH-RELATED QUALITY OF LIFE IN HEAD AND NECK CANCER
Authors: VanCleave Janet H , Fall-Dickson Jane M 
Published: November 2019

Abstract
Patients treated for head and neck cancer may experience impaired eating and talking that may affect their ability to undergo social activities. We conducted a secondary data analysis to explore: 1) prevalence of perceived social isolation, and 2) association between perceived social isolation and health-related quality of life (HRQoL) in patients with head and neck cancer. Data were collected during a clinical usefulness study of the Electronic Patient Visit Assessment (ePVA), a valid, reliable web-based patient-reported symptom measure for head and neck cancer. The study population consisted of 56 patients recruited during or after treatment for head and neck cancer. Perceived social isolation data were collected using the ePVA. HRQoL data were collected using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, a valid measure frequently used in the head and neck cancer population. Data analysis consisted of descriptive statistics and Student’s T-Test. The study population consisted primarily of persons &gt; 60 years (mean age = 61.5 + 12), male (68%), White (77%), and receiving surgery, chemotherapy, radiation therapy or combination of these treatments (70%). Among participants, 36% reported that their current health situation negatively affected their social activities. Reasons for perceived social isolation included fatigue, feeling ill. Statistical analysis found that perceived social isolation was significantly associated with deceased HRQoL (t=5.3, p&lt;.001). We conclude that participants in this sample treated for head and neck cancer were at risk for perceived social isolation, which has previously been reported to negatively influence cancer treatment outcomes.
TARGETING THE NLRP3 INFLAMMASOME IN MECHANISMS OF SLEEP DEPRIVATION-INDUCED NEUROINFLAMMATION
Authors: Smith Chad , Trageser Kyle , Pasinetti Giulio M 
Published: November 2019

Abstract
The purpose of this study was to determine if inhibitors of innate immunity in microglia could attenuate sleep deprivation (SD)-induced psychological impairment, which involve the assembly and activation of the NLRP3 inflammasome. In the study, CD-1 mice were immune-primed with chronic corticosterone treatment (20 mg/kg IP) for two weeks and were subsequently subjected to one bout of 6 hr SD. Mice were sacrificed immediately afterward to measure cytokine concentrations and caspase-1 activity. We found a significant upregulation of caspase-1 activity in the brain of both mice primed with corticosterone then subjected to sleep deprivation as well as mice only subjected to sleep deprivation (p &lt; 0.01). Increased caspase-1 was NLRP3-dependent as treatment with MCC950 (20 mg/kg IP), an inhibitor of NLRP3 inflammasome assembly, completely attenuated SD-induced caspase-1 activity (p &lt; 0.01). Additionally, in SD mice we observed increased microglia reactivity as quantified by IBA+ cells and an increased number of microglia that had reactive amoeboid morphologies, as measured through immunohistochemistry. The administration of the NLRP3 specific inhibitor MCC950 similarly prevented SD-induced changes in microglia morphology. The study established that consequential effects of SD- induced inflammasome activation and microglia activation could be prevented by a selective NLRP3 inhibitor. Given the preliminary beneficial effects of targeting NLRP3 in SD, future investigations will establish the clinical efficacy of microbiome-derived polyphenolic compounds, which we have shown provide protection against neuroinflammation in models of stress induced psychological impairment, to attenuate SD neuroinflammation by targeting the NLRP3 inflammasome.
PROLONGATION OF HUMAN LIFESPAN BY IMMATURE PEAR EXTRACT MEDIATED SIRTUIN-RELATED GENE EXPRESSION
Authors: Ogita Akira , Murata Wakae , Hasegawa Marina , Yamauchi Ken , Sakai Akiko , Yamaguchi Yoshihiro , Tanaka Toshio , Fujita Ken-ichi 
Published: November 2019

Abstract
Demographics of the world are changing rapidly with older populations growing at an unprecedented rate. Cellular senescence, a decline of cellular function due to aging, causes gradual loss of physiological functions. Several cellular senescence-related chronic diseases, such as metabolic syndrome, cardiovascular disease, cancer, osteoporosis, diabetes, and hypertension, negatively affect the quality of human life. Intervention in the cellular senescence process may reduce these incidences and slow the progression of age-related diseases, while contributing to the longevity of healthy human lifespans. Saccharomyces cerevisiae, the budding yeast, is a simple model system that can provide significant insights into the human genetics and molecular biology of senescence and is considered suitable as a cellular model for research on mammalian cells. The aim of our study was to investigate the anti-aging effects of immature pear fruit extract (IPE) on yeast cells and its possible application to extend healthy lifespan in humans. Anti-aging effects of IPE were investigated using a chronological lifespan assay on S. cerevisiae cells. The chronological lifespan of the yeast treated with IPE at 1% (v/v) was significantly extended than that of untreated cells (p &lt; 0.05). The expression of sirtuin-related genes, which regulate cellular senescence, was examined by reverse transcription-polymerase chain reaction and found to be significantly increased following IPE treatment. These results suggest that sirtuin-related genes have important roles in IPE-regulated lifespan extension, which provides a mechanism by which IPE could affect mammalian cells and potentially extend healthy human lifespans.