bluuebunny/crossref_metadata_2025_split huggingface dataset:
LIFE QUALITY OF FIREFIGHTERS OF THE CHORNOBYL NUCLEAR POWER PLAND DISASTER WITH COMORBIDITY OF ESSENTIAL HYPERTENSION AND GASTROESOPHAGEAL REFLUX DISEASE
Authors: Synelnik V. P. , Tkachenko N. A. , Suprun A. S. 
Published: November 2019

This study was aimed at assessing the quality of life of 52 former fire-fighters of the Chornobyl nuclear power plant disaster with comorbidity of essential hypertension and gastroesophageal reflux disease. The subjects were divided into two groups similar by the sex and age (I group included 26 individuals with essential hypertension and II group included 26 individuals with comorbidity of essential hypertension and gastroesophageal reflux disease), their average age was 58,5±0,8 years. All patients received standard therapy (in accordance with the nosological form) added by the preparation Actovegin "Takeda Austria GmbH" in a dose of 200 mg once a day. The model, which underlies the designing of scales and total measurements of the SF-36 questionnaire, has three levels: 36 questions, 8 scales, formed by 2-10 questions; 2 total measurements, which are combined into scales. After calculating each indicator for separate scale, it was necessary to calculate the value of general indicators for the physical component and the psychological component of health taking into account the Z-value. In addition, when assessing the quality of life, three levels of assessment were conditionally identified: the minimum level ranged from 0 to 40 scores, satisfactory level – from 41 to 70 scores and the optimal ranged from 61 to 100 scores. The patients of the first group when having completed the therapy demonstrated statistically significantly improved indicators from 61.1 (0-100) scores to 71, 3 (0-100) (p ≤ 0.05) that consequently means the restrictions in role functioning due to physical condition (PF) decreased, overall health (OH) improved (scores increased from 42.7 (35-47) to 52.1 (47-60)) as well as the role functioning due to emotional state (ER) from 67.9 (0-100) to 76.5 (0-100) points. The second group when having completed the standard therapy added with Actovegin demonstrated statistically significantly improved indicators for most of the scales, and as a result, the subjective assessment of their quality of life was improved (p ≤ 0.05).
Thus, the study has shown including Actovegin into standard therapy significantly improves most of the life quality parameters in both groups of the former fire-fighters of the Chornobyl nuclear power plant disaster. But, it should be noted that the indicators of pain scales and the state of overall health as parameters of life quality for the patients with comorbidy of hypertension and gastroesophageal reflux disease were fount at a minimum level compared with the patients having essential hypertension that indicates more significant restrictions in some fields of daily life activity for patients with comorbid pathology.
The potential effect of pandan wangi leaf “pandanus amaryllifolius roxb.’’ extract from Indonesia as time sleep inductor
Authors: Sulistiyati Nita Tri , Aisyah Riandini , Sutrisna EM 
Published: November 2019

Sleep plays a role in restoring the body's biochemical and physiological processes which decrease when awake. People is not familiar yet with sleep disturbances, so they rarely seek help. Sleep disturbances can cause family problems and are at risk of fatal traffic accidents. Fragant Pandan leaves (Pandanus amaryllifolius Roxb.) contains alkaloids, saponins and flavonoids which can provide a hypnotic sedative effect. The purpose of this study was to determine the effect of fragant Pandan leaf extract (Pandanus amaryllifolius Roxb.) administration in shortening the sleep induction time of male Swiss Webster strain mice. A post-test only design experimental laboratory study was conducted with control group design. The test animals used were 25 Swiss Webster male mice divided into five groups randomly : G1 group was given distilled water, G2 was given diazepam dose 1 mg / KgBB, the G3, G4 and G5 groups were given fragant Pandan leaf extract with a dose of 4 mg/25g BB, 6 mg/25g BB and 8mg/25g BB, respectively. One Way ANOVA statistical test showed significant differences in mice sleep onset (p=0.000) between groups. The results of the Post Hoc test using LSD analysis showed that there were significant differences between positive controls with groups G3, G4 and G5. Fragrant Pandan leaf extract dose of 8 mg/g BB can shorten the time of mice sleep induction male Swiss Webster strain mice. While the dose of 4 mg/g BB cannot shorten the time of induction of sleeping mice.
Keywords: Fragant Pandan leaf extract; Hypnotic-sedative; Sleep disturbances.
Public Health concern for a Nipah Virus disease
Authors: Surana Ajaykumar Rikhabchand , Kumbhare Manoj Ramesh , Abhale Apurva Uttamrao , Bhoir Ankita Ankush , Agrawal Shivam Puranmalgi 
Published: November 2019

Nipah virus (NiV) is a pathogenic paramyxovirus that has been responsible for sporadic outbreaks of respiratory and encephalitic disease in tropical countries. Elevated case mortality rate has also been connected with recent outbreaks in India (Kerala), Malaysia and Bangladesh. The virus generally infects animals like pigs and bats, but they do not show any symptoms of NiV. The mortality rate in NiV infected humans is more as compared to other mammals. The patient usually shows no symptoms to headache fever, cough, dyspnea, confusion and more consequences lead to a coma. Although there are no drugs or vaccines available against this severe disease, precaution and awareness reduce the risk of NiV-infection. This review will be helpful to save the life of people and decrease death by the NiV-infection outbreak.
Keywords: Diagnosis, Henipavirus, Nipah virus, Prevention and treatment
PENERAPAN METODE VISUAL AUDITORY DALAM PENINGKATAN KEBERHASILAN TOILET TRAINING PADA ANAK PRASEKOLAH
Authors: Maghfuroh Lilis 
Published: November 2019

Toilet training or training for bowel and bladder is a major task in preschoolers. Since the percentage preschoolers who use diapres in RA Perwanida 3 Sukoanyar Turi, it proves that the children has not succeeded in toilet training. This study aims to determine the effect of visual auditory on toilet training in preschoolers. The design used "Pre-Experimental" (One-group pretest-posttest design), population was 55 children with a sample of 49 children using taken simple random sampling by the Wilcoxon test. Data collection used questionnaires confirmed in the form of percentage and narrative. The results obtained Z = -2.887 with significant p = 0.004 where (p <0.05). So was accepted meaning that there is a visual auditory influence on toilet training in preschoolers. This study can provide input for parents to teach toilet training with visual auditory so that children can understand more easily and have interest.
Ethico-legal aspects of CRISPR Cas-9 genome editing: A balanced approach
Authors: Dayan Fazli 
Published: November 2019

Notably, reproductive technology and its applications in human subject are not only debatable ethically but also religiously, where objections are raised by the contemporary scholars and specialists of the field on CRISPR Cas-9 due to its potential application for the genome editing. This does however generated a dialogue both in religion and modern ethico-legal world regime. Some contemporary bioethicists are of the view that this technology is one of those issues which have the most complex ethical concerns, fearing that this technology could transforms with the expectations and ambitions about human control over the biological world. Consequently, this is an area of anxiety not only for the bioethicists but also for the theologians. Thus it needs proper investigation, as it is not solely a scientific innovation, but in fact an ethical, legal and biomedical issue.
Bangladesh Journal of Medical Science Vol.19(1) 2020 p.11-16
Évolution de la densité et de la réfractivité spécifique lors de l'altération sous-marine des verres basaltiques
Authors: Noack Yves , Crovisier Jean-Louis 
Published: November 2019

L'altération sous-marine de basse température transforme les verres basaltiques en un matériel, appelé palagonite, évoluant vers des argiles. La connaissance des densités (d, mesurées par flottaison) permet de calculer les bilans chimiques de cette altération. La réfractivité spécifique (n — 1/d, n indice de réfraction étant mesuré par immersion à l'aide d'un microréfractomètre Zeiss) est fonction de la composition chimique. Les échantillons étudiés proviennent de l'Atlantique Nord et de la dorsale Est-Pacifique. La densité des verres frais varie de 2,74 à 2,80, l'indice de réfraction de 1,594 à 1,611 ; la réfractivité spécifique mesurée (0,212 à 0,222) est voisine de celle obtenue par calcul à partir de la composition chimique. L'indice de réfraction de la palagonite varie de 1,533 à 1,583 ; la densité (1,82 à 2,50) et la réfractivité spécifique (0,307 à 0,229) suivent le degré d'évolution de l'altération. Ces variations de la densité et de la réfractivité spécifique sont fonction de l'hydratation, de la cristallinité et des variations chimiques au cours de l'altération.
NEGATIVE IMPACT OF THE TP53 GENE MUTATIONS ON THE EFFICACY OF THE THERAPY OF MANTLE CELL LYMPHOMA. INTERIM RESULTS OF THE MCL-2016 PROTOCOL
Authors: Koroleva D. A. , Gabeeva N. G. , Kuzmina L. A. , Tsygankova S. V. , Bulygina E. S. , Rastorguev S. M. , Nedoluzhko A. V. , Saenko S. S. , Naraikin O. S. , Gavrilina O. A. , Biderman B. V. , Galtseva I. V. , Kovrigina A. M. , Obukhova T. N. , Zvonkov E. E. 
Published: November 2019

Introduction. The prognosis of mantle cell lymphoma (MCL) is determined by both the intensification of the first-line therapy and the biological characteristics of the tumour.Aim. To assess the MCL incidence rate, as well as the survival rate of MCL patients with TP53 gene mutations.Materials and methods. The prospective study MCL-2016 aimed at identifying TP53 gene mutations was carried out among 24 MCL patients from January 2016 to December 2018. TP53 gene mutations were screened using Sanger sequencing (exons 1(2)–11). No TP53 gene mutations were identified in 20 patients (20 mutp53-), with TP53 gene mutations (4 mutp53 +) being observed in 4 patients.Results. 17 MCL patients (mut p53-) underwent two cycles of R-BAC (rituximab, bendamustine, cytarabine) and two cycles of R-HA (rituximab, cytarabine 12 g/m2 ) with the subsequent transplantation of autologous hematopoietic stem cells. Following therapy, minimum residual disease (MRD) was undetected in all 17 patients, with 3 patients still undergoing therapy. All patients, who completed the therapy, remain in complete remission with a median follow-up of 5 months following the transplantation of autologous hematopoietic stem cells (from 1 to 17 the months). The prognosis in MCL patients with TP53 gene mutations was worse. In the course of this study, two patients with TP53 gene mutations died of progressing MCL in spite of intensive therapy. In two patients with TP53 gene mutation, allogeneic hematopoietic stem cells were transplanted from unrelated completely identical donors. After undergoing the transplantation, the patients are alive and remain in complete remission (observation periods of 3 and 27 months).Conclusion. Following R-BAC/R-HA therapy, all patients from the mutp53- group reached complete clinical and MRDnegative remission, with an acceptable toxicity profile. For MCL patients with TP53 gene mutations, the transplantation of allogeneic hematopoietic stem cells constitutes the only effective treatment.
CHANGES IN THE PARAMETERS OF IRON METABOLISM IN RATS’ BLOOD UNDER DECIMETRIC ELECTROMAGNETIC RADIATION
Authors: Abbasova M. T. , Gadzhiev A. M. 
Published: November 2019

Introduction. The intensive development of radio and electrical communications, as well as various electronic devices, leads to the electromagnetic pollution of the environment.Aim. In this work, the authors set out to study the serum iron parameters of rats exposed to chronic electromagnetic radiation (EMR) of the decimeter range.Materials and methods. The research was carried out on rats that were divided into experimental and control groups. The experimental group was further divided into 4 subgroups of 10 animals each, which were subsequently exposed to electromagnetic radiation at a frequency of 460 MHz (Volna-2 apparatus) for 1, 2, 3 and 4 weeks. The control group (10 rats) was exposed to pretend irradiation, with the device being turned off. The following parameters were estimated: serum iron (SI), total iron-binding capacity (TIBC) and unsaturated iron-binding capacity (UIBC) of serum, transferrin saturation (TS), as well as serum concentrations of transferrin, haptoglobin, malondialdehyde and lipid hydroperoxides.Results. Differences in the SI concentration were found in the subgroups of animals exposed to radiation for 3 and 4 weeks (44.1 ± 3.1 μmol/l and 56.8 ± 4.4 μmol/l, respectively), as compared to the control group (30.5 ± 3.3 μmol/l). In experimental animals, TIBC increased by 41 % (p <0.05) — relative to the control group (110.8 ± 10.1 μmol/l) — only following 3 weeks of irradiation (156.2 ± 18.2 μmol/l), with a decrease in TIBC to 123.6 ± 16.4 μmol/l being noted during the 4th week. The concentration of transferrin increased from 45.6 ± 8.0 μmol/l (control) to 81.0 ± 11.5 μmol/l during the 3rd week of radiation exposure, with a decrease to 55.9 ± 6.7 μmol/l being observed during the 4th week. TS increased from 27.5 % (control) to 45.9 % only following 4 weeks of irradiation. The content of lipid hydroperoxides and malondialdehyde in the blood of irradiated rats was higher, as compared to the control animals. The serum concentration of haptoglobin amounted to 26.7 % in the control group, reaching 53.8 mg % and 47.8 mg % following 3 and 4 weeks of exposure, respectively.Conclusion. The total chronic exposure to decimetric EMR produces an oxidising effect on organisms.
REDUCED DOSING REGIMEN OF ENZYME REPLACEMENT THERAPY IN ADULT PATIENTS WITH TYPE I GAUCHER DISEASE: PRELIMINARY RESULTS
Authors: Ponomarev R. V. , Lukina K. A. , Sysoeva E. P. , Chavynchak R. B. , Solovyeva A. A. , Yatsyk G. A. , Kulikov S. M. , Lukina E. A. 
Published: November 2019

Introduction. Gaucher disease (GD) belongs to the group of lysosomal storage diseases. Enzyme replacement therapy (ERT) is considered to be the current standard in GD treatment. No reduced ERT regimen has thus far been developed. Aim. To develop an optimal reduced ERT regimen for adult patients with type I GD, which is scientifically and economically viable.Materials and methods. The study included 100 adult patients with type I GD who achieved treatment goals following at least two years of the standard ERT regimen. Patients were prescribed a reduced ERT regimen, which consisted in increasing the interval between the infusions of the recombinant enzyme up to 4 weeks, at a dose of 15–20 units/kg of body weight. The efficacy of the reduced ERT regimen was assessed once every 12 months according to main GD parameters. The follow-up period in the study ranged from 12 to 36 months.Results. The patients with type I GD who achieved treatment goals following the standard ERT regimen and were then prescribed a reduced ERT regimen retained a stable therapeutic effect of the initial treatment according to all parameters: no clinically significant differences found in haemoglobin and platelet levels, spleen size and specific infiltration of femur bone marrow.Conclusion. An increase in the intervals between infusions of the recombinant glucocerebrosidase up to 4 weeks for 12, 24 and 36 months did not lead to worsening of the laboratory and instrumental parameters associated with GD.
CLONE OF PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA AND OTHER PREDICTORS OF THE RESPONSE TO IMMUNOSUPPRESSIVE THERAPY IN PATIENTS WITH IDIOPATHIC APLASTIC ANAEMIA
Authors: Fidarova Z. T. , Abramova A. V. , Luchkin A. V. 
Published: November 2019

Introduction. The pathogenesis of acquired aplastic anaemia (AA) is based on immune-mediated development of bone marrow failure. The absence of clear reasons for the development of immune aggression determines the relevance of investigations aimed at studying genetic disorders in the remaining pool of hematopoietic stem cells, in the hematopoietic niche, as well as mechanisms underlying the failure of immunological tolerance.Aim. The present literature review describes the most relevant markers used for characterising AA patients on the basis of their possible response to immunosuppressive therapy (IT) and for forming groups being at risk of developing refractoriness and clonal evolution.General findings. The overall survival probability in patients with AA following program IT is comparable to the results of transplanting allogeneic hematopoietic blood stem cells (allo-HSCT) from a related donor in the first line of therapy. According to current Russian and international recommendations, the tactics for treating AA patients is determined by the patient’s age and the presence of an HLA-identical sibling. Allo-HSCT from a related HLA-identical donor is a method used for treating patients younger than 40 years; however, the possibility of performing allo-HSCT is limited by donor availability. Although the event-free survival probability during IT is inferior to the results of allo-HSCT, IT remains the main treatment method for most patients with AA. In order to minimise adverse outcomes, it is necessary to consider predictors of treatment efficacy along with the likelihood of developing late clonal evolution as early as at the AA diagnosis stage. Patient evaluation and formation of risk groups will facilitate selection of the most optimal treatment approach at the therapy planning stage, which includes either IT combination with thrombopoietin receptor agonists, or a search for an unrelated HLA-compatible donor and timely allo-HSCT.
THERAPY OF THE RESISTANT FORMS OF SUBCUTANEOUS PANNICULITIS-LIKE T-CELL LYMPHOMA
Authors: Gorenkova L. G. , Kravchenko S. K. , Silaev M. A. , Ryzhikova N. V. 
Published: November 2019

Introduction. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) belongs to a rare group of skin lymphoproliferative disorders, which is characterised by panniculitis-like clinical manifestations, the α/β cytotoxic immunophenotype of tumour cells, as well as a multidirectional course from indolent to aggressive forms.Aim. To examine patients with SPTCL having an aggressive clinical course and characterised by refractoriness to several lines of chemotherapy.Results. We present two case reports of patients with a generalised lesions and unfavourable prognostic factors, who achieved complete long-term remission of the disease as a result of gemcitabine chemotherapy.Conclusion. Despite the fact that both observed SPTCL patients demonstrated refractoriness to at least three types of treatment, the use of gemcitabine allowed long-term complete remissions of the disease to be achieved.
Necesidad de incrementar la carrera de Ingeniería Metalúrgica en las Universidades Peruanas
Authors: Asencios Trujillo Lida Violeta , Berna Tamayo José Alberto , Huari Sulluchuco Carlos William , Quispe Pérez Marcos Luis 
Published: November 2019

En el siguiente artículo, se analizan dos elementos fundamentales: la situación minera en el Perú, y la necesidad de incrementar los estudios de Ingeniería Metalúrgica. Ambos elementos deben estar indisolublemente ligados, ya que responden a necesidades económicas y sociales que cada vez se acentúan más. El trabajo está articulado en varias secciones que inician con un breve análisis histórico del papel de la educación y el desarrollo social, donde se insiste en el rol que juegan las universidades en este rubro. También se ofrecen comparaciones de lo anterior con otros países, tanto dentro del área como a nivel global, para llegar al siguiente objetivo: aportar informaciones necesarias para dar a conocer la urgencia de extender y perfeccionar las carreras universitarias de Ingeniería de Minas en el entorno nacional. Por otra parte, se hace énfasis en los conflictos sociales que lamentablemente se vienen originado y se mantienen en la población relacionada con la minería Para ello se tomaron como base algunos elementos aportados por la tesis de maestría Caminos de encuentro en el manejo de conflictos sociales en el sector minero: caso Cocachacra.
ARAHAN PENGELOLAAN BLOK PEMANFAATAN KESATUAN PENGELOLAAN HUTAN LINDUNG (KPHL) UNIT VI PADA AREAL MODEL MIKRO DAS (MDM) TALAWAAN
Authors: Zaini Badrun ,. , Polii Bobby Vian Jhon , Walangitan Hengki Djemie 
Published: November 2019

This study aims to: (1) Analyze management models with Geographic Information Systems (GIS), (2) Arrange alternative directions for priority management with a combination of GIS and Analytical HirarchyProcess (AHP) and policy direction of land tenure in forest areas that are in the utilization block KPHL Unit VI which is in Talawaan MDM. The method used in this study is a survey method, namely: a method forobtaining field data by means of systematic observation, measurement and recording of the object under study and supported by the results of laboratory analysis. Sampling and field measurements are carried out using strata techniques with consideration to adjusting the location of the collection. Analysis of the data used: a) Estimating the amount of erosion using the formula Universal Soil Loss Equation (USLE), b) The combination of Geographic Information Systems and Analytical Hierarchy Process (AHP) is used to prepare alternatives for decision making. The results of this study indicated that the Management Model formed in the study area is the Community Forest Management Model (HKm) and Community Plantation Forest (HTR) and with a management period of 35 years and can be extended thereafter. Furthermore, the direction of management priorities according to AHP analysis with economic, ecological and social targets is to implement a management model with Land Utilities Type (LUT) Agrorestry, enrichment LUT and reforestation LUT with an economic target value of 429 points, ecological target value of 143 points and weight social target value of 429 points. The direction of the Government's policy for the completion of land tenure in this forest area is to provide management access to forest areas in the form of Social Forestry Program with the Community Forest Management Model (HKm) and Community Plantation Forest (HTR).*eprm*
Изучение пребиотических свойств кисломолочного продукта, обогащенного препаратами инулина, куркумина и хрома
Authors: Яценко Наталия Николаевна , Елисеева Людмила Геннадьевна 
Published: November 2019

В статье представлены результаты изучения пребиотических свойств кисломолочного продукта, обогащенного препаратами инулина, куркумина и хрома.
Исследования проводились на лабораторных мышах, больных сахарным диабетом 2 типа, у которых искусственным путем было спровоцировано заболевание, при котором возникает дисбактериоз кишечника. Исследовался характер изменений количества и состава кишечной микрофлоры, на фоне которого изучался эффект коррекции кишечной микрофлоры при использовании кисломолочного продукта обогащенного препаратами инулина и хрома. Полученные данные после окончания коррекции продуктом свидетельствуют о стабилизации состава кишечной микрофлоры у лабораторных мышей.