bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial
Authors: Hirota Morihisa , Shimosegawa Tooru , Kitamura Katsuya , Takeda Kazunori , Takeyama Yoshifumi , Mayumi Toshihiko , Ito Tetsuhide , Takenaka Mamoru , Iwasaki Eisuke , Sawano Hirotaka , Ishida Etsuji , Miura Shin , Masamune Atsushi , Nakai Yousuke , Mitoro Akira , Maguchi Hiroyuki , Kimura Kenji , Sanuki Tsuyoshi , Ito Tetsuya , Haradome Hiroki , Kozaka Kazuto , Gabata Toshifumi , Kataoka Keisho , Hirota Masahiko , Isaji Shuji , Nakamura Ryoji , Yamagiwa Koki , Kayaba Chie , Ikeda Koji 
Published: November 2019

AbstractBackgroundContinuous regional arterial infusion (CRAI) of protease inhibitor nafamostat mesilate (NM) is used in the context of predicted severe acute pancreatitis (SAP) to prevent the development of pancreatic necrosis. Although this therapy is well known in Japan, its efficacy and safety remain unclear.MethodsThis investigator-initiated and -driven, multicenter, open-label, randomized, controlled trial (UMIN000020868) enrolled 39 patients with predicted SAP and low enhancement of the pancreatic parenchyma on computed tomography (CT). Twenty patients were assigned to the CRAI group, while 19 served as controls and were administered NM at the same dose intravenously (IV group). The primary endpoint was the development of pancreatic necrosis as determined by CT on Day 14, judged by blinded central review.ResultsThere was no difference between the CRAI and IV groups regarding the percentages of participants who developed pancreatic necrosis (more than 1/3 of the pancreas: 25.0%, range 8.7–49.1% vs. 15.8%, range 3.4–39.6%, respectively,P = 0.694; more than 2/3 of the pancreas: 20%, range 5.7–43.7% vs. 5.3%, range 0.1–26.0%, respectively,P = 0.341). The early analgesic effect was evaluated based on 24-h cumulative fentanyl consumption and additional administration by intravenous patient-controlled analgesia. The results showed that the CRAI group used significantly less analgesic. There were two adverse events related to CRAI, namely bleeding and splenic infarction.ConclusionsCRAI with NM did not inhibit the development of pancreatic necrosis although early analgesic effect of CRAI was superior to that of IV. Less-invasive IV therapy can be considered a viable alternative to CRAI therapy.
Response learning confounds assays of inhibitory control on detour tasks
Authors: van Horik Jayden O. , Beardsworth Christine E. , Laker Philippa R. , Whiteside Mark A. , Madden Joah R. 
Published: November 2019

AbstractThe ability to inhibit prepotent actions towards rewards that are made inaccessible by transparent barriers has been considered to reflect capacities for inhibitory control (IC). Typically, subjects initially reach directly, and incorrectly, for the reward. With experience, subjects may inhibit this action and instead detour around barriers to access the reward. However, assays of IC are often measured across multiple trials, with the location of the reward remaining constant. Consequently, other cognitive processes, such as response learning (acquisition of a motor routine), may confound accurate assays of IC. We measured baseline IC capacities in pheasant chicks, Phasianus colchicus, using a transparent cylinder task. Birds were then divided into two training treatments, where they learned to access a reward placed behind a transparent barrier, but experienced differential reinforcement of a particular motor response. In the stationary-barrier treatment, the location of the barrier remained constant across trials. We, therefore, reinforced a fixed motor response, such as always go left, which birds could learn to aid their performance. Conversely, we alternated the location of the barrier across trials for birds in the moving-barrier treatment and hence provided less reinforcement of their response learning. All birds then experienced a second presentation of the transparent cylinder task to assess whether differences in the training treatments influenced their subsequent capacities for IC. Birds in the stationary-barrier treatment showed a greater improvement in their subsequent IC performance after training compared to birds in the moving-barrier treatment. We, therefore, suggest that response learning aids IC performance on detour tasks. Consequently, non-target cognitive processes associated with different neural substrates appear to underlie performances on detour tasks, which may confound accurate assays of IC. Our findings question the construct validity of a commonly used paradigm that is widely considered to assess capacities for IC in humans and other animals.
Deriving an overall appearance domain score by applying bifactor IRT analysis to the BODY-Q appearance scales
Authors: Geerards Daan , van den Berg Lisa , Pusic Andrea L. , Hoogbergen Maarten M. , Klassen Anne F. , van der Hulst René R. W. J. , Sidey-Gibbons Chris J. 
Published: November 2019

Abstract
Purpose
With the BODY-Q, one can assess outcomes, such as satisfaction with appearance, in weight loss and body contouring patients using multiple scales. All scales can be used independently in any given combination or order. Currently, the BODY-Q cannot provide overall appearance scores across scales that measure a similar super-ordinate construct (i.e., overall appearance), which could improve the scales’ usefulness as a benchmarking tool and improve the comprehensibility of patient feedback. We explored the possibility of establishing overall appearance scores, by applying a bifactor model to the BODY-Q appearance scales.

Methods
In a bifactor model, questionnaire items load onto both a primary specific factors and a general factor, such as satisfaction with appearance. The international BODY-Q validation patient sample (n = 734) was used to fit a bifactor model to the appearance domain. Factor loadings, fit indices, and correlation between bifactor appearance domain and satisfaction with body scale were assessed.

Results
All items loaded on the general factor of their corresponding domain. In the appearance domain, all items demonstrated adequate item fit to the model. All scales had satisfactory fit to the bifactor model (RMSEA 0.045, CFI 0.969, and TLI 0.964). The correlation between the appearance domain summary scores and satisfaction with body scale scores was found to be 0.77.

Discussion
We successfully applied a bifactor model to BODY-Q data with good item and model fit indices. With this method, we were able to produce reliable overall appearance scores which may improve the interpretability of the BODY-Q while increasing flexibility.
Detecting bursty terms in computer science research
Authors: Tattershall E. , Nenadic G. , Stevens R. D. 
Published: November 2019

AbstractResearch topics rise and fall in popularity over time, some more swiftly than others. The fastest rising topics are typically called bursts; for example “deep learning”, “internet of things” and “big data”. Being able to automatically detect and track bursty terms in the literature could give insight into how scientific thought evolves over time. In this paper, we take a trend detection algorithm from stock market analysis and apply it to over 30 years of computer science research abstracts, treating the prevalence of each term in the dataset like the price of a stock. Unlike previous work in this domain, we use the free text of abstracts and titles, resulting in a finer-grained analysis. We report a list of bursty terms, and then use historical data to build a classifier to predict whether they will rise or fall in popularity in the future, obtaining accuracy in the region of 80%. The proposed methodology can be applied to any time-ordered collection of text to yield past and present bursty terms and predict their probable fate.
Knowledge and Attitudes Towards Obesity and Bariatric Surgery in Chinese Nurses
Authors: Fan Meiling , Hong Jie , Cheung Pik Nga , Tang Shutong , Zhang Jing , Hu Songhao , Jiang Shuwen , Chen Xiaomei , Yu Shuqing , Gao Lilian , Wang Cunchuan , Chen Weiju , Yang Wah 
Published: November 2019

Abstract
Background
Obesity has become a global epidemic. Surgical treatment of obesity and metabolic disorders in China is increasing rapidly, but it is still a new discipline even to health professionals. As an important member of the multidisciplinary team, the knowledge and attitudes of nurses provide crucial health care to the patients and support to surgeons.

Objectives
To study the Chinese nurses’ knowledge of obesity and metabolic disorders, and attitudes towards bariatric surgery and to improve their capability of work in this new discipline.

Methods
This is a multicenter study, with the questionnaire distributed to cooperative hospitals in the form of an electronic questionnaire by the First Affiliated Hospital of Jinan University in April 2018. A questionnaire was designed to investigate nurses’ demographic, knowledge, and attitude towards obesity, weight loss, and bariatric surgery.

Results
A total of 5311 questionnaires were received, with an effective rate of 91.8% (4878 questionnaires); 65.2% of nurses had a normal BMI. Nurses generally had a high knowledge of obesity and related cardiovascular diseases (98.6%) and type 2 diabetes mellitus (90.2%). However, there was a lack of knowledge in other related aspects, for example its relations to carcinoma (49.5%), gastroesophageal reflux disease (40.1%), and psychological disorders (49.1%), which are controversial issues in bariatric surgery. It was found that education (p < 0.05) had an important influence to nurses’ knowledge about the comorbidities of obesity. Female nurses had a higher tendency to choose weight loss than males, but male nurses did physical exercise more frequently than females (p < 0.05). Their acceptance of safety (25.1%) and efficacy (22.9%) of bariatric surgery is low, with concerns predominantly about postoperative complications and adverse effects. Surgical nurses had a more optimistic attitude towards surgery (p < 0.05).

Conclusions
Chinese nurses have poor knowledge of obesity-related metabolic disorders and also have poor acceptance of surgical treatment modalities. Our findings suggest that it is crucial to enhance the continuing education of Chinese nurses for obesity, metabolic disorders, and bariatric surgery.
Factoring in Societal Culture in Policy Transfer Design: the Proliferation of Private Sponsorship of Refugees
Authors: Bertram Daniel , Maleki Ammar , Karsten Niels 
Published: November 2019

AbstractThe Canadian model of private sponsorship schemes (PSS) for refugees is becoming an increasingly popular target for policy transfer in the field of migration. This article argues that the influence of societal culture on this transplanting process has played an underexplored role in the literature. We seek to provide original guidance for factoring in cultural elements into the policy transfer framework by demonstrating how specific design choices in PSS transfer display clear cultural associations. A tentative study of nine countries that have adopted different models of PSS corroborates this hypothesis empirically. Our preliminary findings suggest that cultural compatibility may indeed increase the effectiveness of a policy transfer in some instances, while culturally preferred choices being adopted in other cases may result in suboptimal design. This converse interplay indicates that cultural awareness constitutes a crucial element of successful transfer processes and stresses the need to adopt a culturally sensitive perspective more frequently and more explicitly.
Impacts of Hurricane Irma on Florida Bay Islands, Everglades National Park, USA
Authors: Wingard G. Lynn , Bergstresser S. E. , Stackhouse B. L. , Jones M. C. , Marot M. E. , Hoefke K. , Daniels A. , Keller K. 
Published: November 2019

AbstractHurricane Irma made landfall in south Florida, USA, on September 10, 2017 as a category 4 storm. In January 2018, fieldwork was conducted on four previously (2014) sampled islands in Florida Bay, Everglades National Park to examine changes between 2014 and 2018. The objectives were to determine if the net impact of the storm was gain or loss of island landmass and/or elevation; observe and quantify impacts to mangroves; and identify distinctive sedimentary, biochemical, and/or geochemical signatures of the storm. Storm overwash deposits were measured in the field and, in general, interior island mudflats appeared to experience deposition ranging from ~ 0.5 to ~ 6.5 cm. Elevation changes were measured using real-time kinematic positioning and satellite receivers. Comparison of 2014 to 2018 elevation measurements indicates mangrove berms and transitional areas between mudflats and berms experienced erosion and loss of elevation, whereas interior mudflats gained elevation, possibly due to Hurricane Irma. Geographic information system analysis of pre- and post-storm satellite imagery indicates the western-most island, closest to the eye of the storm, lost 32 to 42% (~ 11 to 13 m) of the width of the eastern berm, and vegetated coverage was reduced 9.3% or ~ 9700 m2. Vegetated coverage on the eastern-most island was reduced by 1.9% or ~ 9200 m2. These results are compared to previous accounts of hurricane impacts and provide a baseline for examining long-term constructive and destructive aspects of hurricanes on the islands and the role of storms in resiliency of Florida Bay islands.
Adolescent social isolation and premature mortality in a Swedish birth cohort
Authors: Högnäs Robin S. , Almquist Ylva B. , Modin Bitte 
Published: November 2019

AbstractResearch shows consistently that social ties are important for longevity, and they may be particularly important during adolescence. An absence of social ties, or social isolation, during adolescence may adversely affect long-term health and wellbeing. While prior research has examined associations between isolation from friends and long-term health, and having no siblings and mortality, no study (of which we are aware) considers jointly both the role of having no friends and no siblings, nor more generally with whom adolescents spend time, and the risk of premature mortality. This paper extends the literature by drawing on data from the Stockholm Birth Cohort Study to examine the association between different types of social isolation during adolescence (i.e., an absence of friends, siblings, and time with other adolescents) and the risk of premature mortality by midlife. Results suggest that having no siblings, being unliked at school, and spending (mostly) no time with other adolescents, increases the risk of premature mortality. The association between being unliked and premature mortality was attenuated by demographic and adolescent characteristics. Consistent with our expectations, net of a robust set of covariates, adolescents who had no siblings and mostly spent no time with other adolescents (i.e., isolates) were the group most vulnerable to premature mortality by midlife. However, this was only true for females.
The Increasing Issue of Vancomycin-Resistant Enterococci and the Bacteriocin Solution
Authors: Reinseth Ingvild S. , Ovchinnikov Kirill V. , Tønnesen Hanne H. , Carlsen Harald , Diep Dzung B. 
Published: November 2019

AbstractEnterococci are commensals of human and other animals’ gastrointestinal tracts. Only making up a small part of the microbiota, they have not played a significant role in research, until the 1980s. Although the exact year is variable according to different geographical areas, this was the decade when vancomycin-resistant enterococci (VRE) were discovered and since then their role as causative agents of human infections has increased. Enterococcus faecium is on the WHO’s list of “bacteria for which new antibiotics are urgently needed,” and with no new antibiotics in development, the situation is desperate. In this review, different aspects of VRE are outlined, including the mortality caused by VRE, antibiotic resistance profiles, animal-modeling efforts, and virulence. In addition, the limitations of current antibiotic treatments for VRE and prospective new treatments, such as bacteriocins, are reviewed.
Suggestions for improving the design of clinical trials in multiple sclerosis—results of a systematic analysis of completed phase III trials
Authors: Gehr Sinje , Kaiser Thomas , Kreutz Reinhold , Ludwig Wolf-Dieter , Paul Friedemann 
Published: November 2019

AbstractThis manuscript reviews the primary and secondary endpoints of pivotal phase III trials with immunomodulatory drugs in multiple sclerosis (MS). Considering the limitations of previous trial designs, we propose new standards for the planning of clinical trials, taking into account latest insights into MS pathophysiology and patient-relevant aspects. Using a systematic overview of published phase III (pivotal) trials performed as part of application for drug market approval, we evaluate the following characteristics: trial duration, number of trial participants, comparators, and endpoints (primary, secondary, magnetic resonance imaging outcome, and patient-reported outcomes). From a patient perspective, the primary and secondary endpoints of clinical trials are only partially relevant. High-quality trial data pertaining to efficacy and safety that stretch beyond the time frame of pivotal trials are almost non-existent. Understanding of long-term benefits and risks of disease-modifying MS therapy is largely lacking. Concrete proposals for the trial designs of relapsing (remitting) multiple sclerosis/clinically isolated syndrome, primary progressive multiple sclerosis, and secondary progressive multiple sclerosis (e.g., study duration, mechanism of action, and choice of endpoints) are presented based on the results of the systematic overview. Given the increasing number of available immunotherapies, the therapeutic strategy in MS has shifted from a mere “relapse-prevention” approach to a personalized provision of medical care as to the choice of the appropriate drugs and their sequential application over the course of the disease. This personalized provision takes patient preferences as well as disease-related factors into consideration such as objective clinical and radiographic findings but also very burdensome symptoms such as fatigue, depression, and cognitive impairment. Future trial designs in MS will have to assign higher relevance to these patient-reported outcomes and will also have to implement surrogate measures that can serve as predictive markers for individual treatment response to new and investigational immunotherapies. This is an indispensable prerequisite to maximize the benefit of individual patients when participating in clinical trials. Moreover, such appropriate trial designs and suitable enrolment criteria that correspond to the mode of action of the study drug will facilitate targeted prevention of adverse events, thus mitigating risks for individual study participants.
Assessment of geospatial capability index for siting waste dump/landfill to control groundwater geopollution using geographic information system (GIS) approach: case study of Abakaliki area and environs, Southeastern Nigeria
Authors: Onwe Mkpuma Rock , Nwankwor G. I. , Ahiarakwem C. A. , Abraham Ema Michael , Emberga T. T. 
Published: November 2019

AbstractUnderstanding spatial variation of rock and soil is important for capability precision as well as groundwater contamination or geopollution management. In view of waste dump/landfills, geoenvironmental hazards ravaging our land including surface and groundwater contamination, site suitability indexing, spatial distribution and characteristics of underlying rock and soil matter are studied. Rock and soil samples were collected in a systematic grid pattern using simple drill core rig and hand auger. Geostatistical and soil property analyses were conducted on each grid. Groundwater aquifer vulnerability to leachate was studied using depth to water table, recharge (precipitation), aquifer material, topographic slope, impact on vadose zone/vadose zone material and hydraulic conductivity (DRASTIC) and geophysical methods. Human population growth analysis indicates tremendous waste generation. Flash points of waste generation and dumping were noted. Geographical positioning system was used to take record of sampling point coordinates. Using a sufficient dataset, each grid indicative factor is objectively scaled, weighed and assigned a numerical rating according to their relative importance employing site suitability (S) analysis approach in an empirical equation. Results were imported into a geographic information system (GIS) platform to generate thematic maps. The results showed that subsurface rock and soil characteristics are neither spatially nor vertically homogeneously distributed. Thematic maps were generated and further interpolated in the GIS domain to produce a composite waste dump/landfill suitability index map.
Determining skin zone properties from injectivity tests in single- and multilayer reservoirs
Authors: Bela Renan Vieira , Pesco Sinésio , Barreto Abelardo 
Published: November 2019

AbstractThis work proposes an interpretation technique for injectivity tests that provides a new estimation for skin zone permeability and radius in single-layer reservoirs. A means to compute the reservoir skin factor in multilayer commingled reservoirs is also presented. Under the assumption that layer flow-rates are decoupled, the suggested method was extended to compute individual layer permeabilities and skin factors. The results indicate that this hypothesis is valid in reservoirs where layer skin factors are similar.
Two-valenced association schemes and the Desargues theorem
Authors: Hirasaka Mitsugu , Kim Kijung , Ponomarenko Ilia 
Published: November 2019

AbstractThe main goal of the paper is to establish a sufficient condition for a two-valenced association scheme to be schurian and separable. To this end, an analog of the Desargues theorem is introduced for a noncommutative geometry defined by the scheme in question. It turns out that if the geometry has enough many Desarguesian configurations, then under a technical condition, the scheme is schurian and separable. This result enables us to give short proofs for known statements on the schurity and separability of quasi-thin and pseudocyclic schemes. Moreover, by the same technique, we prove a new result: given a prime p, any $$\{1,p\}$$

{
1
,
p
}

-scheme with thin residue isomorphic to an elementary abelian p-group of rank greater than two, is schurian and separable.