bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aesthetics and comfort requirements of breast prosthesis in the case of mastectomy in cancer patients
Authors: Oh Hee-Kyoung , Vu Chi Cuong , Kim Jooyong 
Published: December 2020

PurposeThe objective of this study is to investigate an appropriate breast prosthesis of pattern with center of gravity that exerts less clothing pressure on women who are breast cancer patients.Design/methodology/approachFrom November 2018, clothing pressure was measured with silk fabric breast prosthesis (SBP) of three different patterns above an affected breast (AB) by the force-sensitive resistance (FSR) sensor.FindingsWhen wearing SBP above the AB, clothing pressure was significantly different in the healthy breast (HB) and the AB; the highest clothing pressure was at the center of nipple in the AB. Meanwhile, the top of the nipple area in the HB experienced higher clothing pressure than before wearing it. Because wearing heavy breast prosthesis presses down, influencing the HB as well. However, below the bottom of the breast bra curve in the AB, clothing pressure becomes lower than before wearing it. Because when the breast prosthesis was inserted into the bra, the clothing pressure not only increased generally but also the clothing pressure divided at some areas. Also, when comparing three different patterns of SBP, the result indicated a significant difference in clothing pressure only inside of breast cap and the center of gravity of the lower breast prosthesis has the lowest clothing pressure.Research limitations/implicationsA comparison in pressure based on a circuit design (FSR sensors) and an air pack (AP) device was presented. Further work will be focused on the generation of pressure clothing for breast cancer patients.Originality/valueThe paper demonstrates that wearing breast prosthesis with a center of gravity in the lower position from the nipple area has less effect on breast cancer women. The results of this paper facilitate the pattern design of clothing for patients.
The paratext of digital documents
Authors: Skare Roswitha 
Published: December 2020

PurposeThe purpose of this study is to provide a discussion on how to apply Genette's concept of the paratext to analyze digital documents. The article argues that the concept, despite its shortcomings, is useful because it gives us the terminology to analyze elements often ignored and overlooked.Design/methodology/approachBy taking Gérard Genette's concept of the paratext as point of departure, the paper focuses on three controversial issues in the scholarly work about paratext and digital documents: the division of paratext into peritext and epitext, the explosive growth of paratext and the question of authorization of text and paratext.FindingsQuestions related to the spatial division of the paratext into peritext and epitext, the difficulty of where to draw the line between text and paratext and the question of authorization are not new for digital documents but did already occur in the analog world. Even if many decisions like what to include and what to exclude in an analysis are left to the researcher, this does not mean that Genette's concept is unsuitable for digital documents. On the contrary, the concept gives us the terminology to analyze elements of often ignored and overlooked, also for digital documents.Research limitations/implicationsAs a scholar in the humanities the author can only relate to and therefore analyze what the author can experience and observe on screen level.Originality/valueIn providing a discussion of digital documents and some of the controversial issues discussed by other researchers, this article shows the relevance of Genette's concept, also for our work with digital documents.
Innovation resistance theory perspective on the use of food delivery applications
Authors: Kaur Puneet , Dhir Amandeep , Ray Arghya , Bala Pradip Kumar , Khalil Ashraf 
Published: December 2020

PurposeThe current study tries to better understand the resistance toward food delivery applications (FDAs). This study has adapted the existing criteria to measure different consumer barriers toward FDAs. It also examined the relationships between various consumer barriers, intention to use FDAs and word-of-mouth (WOM).Design/methodology/approachThis study utilized the innovation resistance theory (IRT) and a mixed-method approach comprised of qualitative essays submitted by 125 respondents and primary surveys (N = 366) of FDA users.FindingsTradition barrier (trust) shared a negative association with use intention, while image barrier (poor customer service) shared a negative association with WOM. The intention to use was positively associated with WOM. Additionally, the study results reveal that image barrier (poor customer experience) and value barrier (poor quality control) were, in fact, positively related to WOM. This study also discusses the managerial and theoretical implications of these findings and the scope for further research on FDAs.Originality/valueFDAs have revolutionized the food delivery industry and made it more comfortable and convenient for the consumers. However, FDA service providers are facing challenges from both customers and restaurants. Although scholars investigated customer behavior toward FDAs, no prior study has focused on consumer barriers toward FDA usage.
Property investment: gearing and portfolio returns
Authors: French Nick , Patrick Michael 
Published: December 2020

PurposeThe aim of this study is to comment upon the relatively straightforward but often misunderstood role of gearing (or leverage) on the potential equity return of a property investment portfolio.Design/methodology/approachThis education briefing is an explanation of the how the addition of individual assets to a portfolio can, with gearing, impact upon the portfolio return.FindingsAlthough, this case study is relatively straightforward, it shows how portfolios can be geared to give enhanced returns at differing, aggregate and levels of risk.Practical implicationsThe process of borrowing at a bank rate below the return rate on an investment project can increase the equity return of the project as long as all incomes and discount rate remain at appropriate levels.Originality/valueThis is a review of existing models.
An analysis of the experiences based on experimental marketing: pandemic COVID-19 quarantine
Authors: Tavares Fernando , Santos Eulália , Diogo Ana , Ratten Vanessa 
Published: December 2020

PurposeThe purpose of this article is to analyze the experiences experienced during the COVID-19 pandemic quarantine, based on an experimental marketing perspective and to validate a scale of experiences for the quarantine context.Design/methodology/approachThe life of a human being is a sum of the experiences that occur in their daily life, from experiences at home, to experiences at work, shopping, holidays and, essentially, with other human beings. However, experiences during the quarantine period became limited to experiences at home. For this, we used a questionnaire survey that analyzes the experiences experienced by individuals. The sample consists of 726 individuals who were in Portugal during the quarantine and confinement period.FindingsThe results show that the exploratory and confirmatory factor analysis produced a structure with four factors that the authors called Sense and Feel, Pandemic Feel, Pandemic Think and Act. The experiences are manifested with greater intensity in the factors Pandemic Think and Sense and Feel. The scale of experiences used showed to have convergent and discriminant validity and adequate internal consistency. It is expected that the present study will contribute to increase scientific knowledge in the behavioral area and in the area of positive psychology in the context of pandemic and confinement situations.Originality/valueThe results achieved become useful for health and marketing professionals, which allow them to define appropriate strategies to better serve the population in order to improve people's health, well-being and quality of life.
A generation of bricoleurs: digital entrepreneurship in Kenya
Authors: Grzeslo Jenna 
Published: December 2020

PurposeThe purpose of this study is to explore how the uptake of digital technologies influences youth entrepreneurship in Kenya.Design/methodology/approachThis study utilizes 28 semi-structured interviews with entrepreneurs age 21–35 in Nairobi, Kenya. Interview transcripts were analyzed using open- and closed-coding.FindingsMillennial entrepreneurs embrace change and challenges by harnessing mobile technologies and social media. In doing so, they are engaging in what French sociologist Lévi-Strauss called “bricolage,” or “making do with what's at hand.”Originality/valueThis study explores a unique segment of entrepreneurs, Millennials in Kenya and identified the ways in which digital entrepreneurship represents a form of bricolage.
Preoperative concurrent chemoradiotherapy MRI characteristics favouring pathologic complete response in patients with rectal cancer: Usefulness of MR T2‐stage as an ancillary finding for predicting pathologic complete response
Authors: Lee Hyeon Jin , Chung Woo‐Suk , An Ji hae , Kim Jung Hoon 
Published: December 2020

AbstractIntroductionThis study sought to assess preoperative concurrent chemoradiotherapy (CRT) magnetic resonance imaging (MRI)‐based findings according to a structured MRI report template for primary staging of rectal cancer, and to evaluate the prognostic relevance of the pre‐CRT MRI‐based findings in patients with rectal cancer after CRT.MethodsWe retrospectively evaluated pre‐ and post‐CRT MRI data of patients with pathologically proven rectal adenocarcinoma, between January 2008 and October 2019. Image interpretation was performed independently by two radiologists and each reviewer assessed the cancer characteristics on MRI, based on the structured MRI report for primary staging. MRI‐based findings associated with pathologic complete tumour regression grade (TRG) after CRT were analysed by univariate and multivariate analysis. Significant factors from pre‐CRT MRI were weighted to score mrTRG in post‐CRT MRI.ResultsOn univariate analysis, MR T‐stage, tumour infiltration, mesorectal fascia involvement, extramural vascular invasion and serum carcinoembryonic antigen level correlated significantly with pathologic complete response (pCR). Multivariate analysis identified that only MR T‐stage was independently associated with pCR (odds ratio, 3.89, 95% confidence interval, 1.18–12.84; P = 0.0278). Adding MRI‐based T2‐stage as an ancillary finding to mrTRG statistically significantly improved the sensitivity as compared to using only mrTRG for considering a CR. T2_mrTRG was significantly different in terms of the time to tumour progression between the CR and non‐CR group.ConclusionsThe MR T2‐stage was independently associated with pCR after CRT in patients with rectal cancer and was helpful as ancillary predictive factor, adding to mrTRG for prediction of pCR.
Co‐ablation versus cryoablation for the treatment of stage III–IV non‐small cell lung cancer: A prospective, noninferiority, randomized, controlled trial (RCT)
Authors: Yang Wuwei , An Yonghui , Li Quanwang , Liu Chuanbo , Zhu Baorang , Huang Qianfu , Zhao Mengfei , Yang Fei , Feng Huasong , Hu Kaiwen 
Published: December 2020

AbstractBackgroundThis study compared a co‐ablation (CA) system, which is a novel ablation device, with an argon‐helium cryoablation (AHC) system. We aimed to compare the efficacy and safety of CA and AHC for the treatment of stage III–IV non‐small cell lung cancer (NSCLC).MethodsWe conducted a multicenter randomized controlled trial (RCT) to determine whether CA was noninferior to AHC. The primary efficacy endpoints were the iceball coverage rate (ICR) and the disease control rate (DCR) one month after treatment. Noninferiority was declared if the lower limit of two‐sided 95% confidence interval (CI) was less than 10%. The ICR and DCR were identified by logistic regression. Treatment safety was assessed.ResultsA total of 81 patients underwent randomization (41 assigned to the CA and 40 assigned to the AHC groups)and transthoracic ablation. The ICRs in the CA and AHC groups were 99.24% ± 2.18% and 98.66% ± 3.79%, respectively. Central lesions were associated with an increased risk of an incomplete ICR. The DCRs in the CA and AHC groups were 97.6% and 95%, respectively. A smaller lesion area in the CA group was significantly correlated with a better DCR. The rate of complications was 29.26% in the CA group and 30% in the AHC group. (P = 0.943). There was less probe usage per patient in the CA group.ConclusionsWe determined that CA is noninferior to AHC in terms of efficacy and safety for the treatment of stage III–IV NSCLC. A smaller lesion area in the CA group was significantly correlated with a better DCR.Key points
CA was noninferior to AHC for stage III–IV NSCLC.
Effects of hypercapnia in sepsis: A scoping review of clinical and pre‐clinical data
Authors: Clyde Thomas P. , Coletta Michael , Jones Christopher W. , Kilgannon Hope , Fuller Brian M. , Trzeciak Stephen , Roberts Brian W. 
Published: December 2020

BackgroundPerform a scoping review of (1) pre‐clinical studies testing the physiological effects of higher PaCO2 levels in the setting of sepsis models and (2) clinical investigations testing the effects of hypercapnia on clinical outcomes in mechanically ventilated patients with sepsis.MethodsWe performed a search of CENTRAL, PUBMED, CINAHL, and EMBASE. Study inclusion criteria for pre‐clinical studies were: (1) bacterial sepsis model (2) measurement of PaCO2, and (3) comparison of outcome measure between different PaCO2 levels. Inclusion criteria for clinical studies were: (1) diagnosis of sepsis, (2) receiving invasive mechanical ventilation, (3) measurement of PaCO2, and (4) comparison of outcomes between different PaCO2 levels. We performed a qualitative analysis to collate and summarize the physiological and clinical effects of hypercapnia according to the recommended methodology from the Cochrane Handbook.ResultsFifteen pre‐clinical and nine clinical studies were included. Among pre‐clinical studies, the individual studies found higher PaCO2 augments tissue blood flow and oxygenation, and attenuates inflammation and lung injury; however, all pre‐clinical studies were found to have some degree of risk of bias. Six of the nine clinical studies were deemed to be good quality. Among clinical studies hypercapnia was associated with increased cerebral perfusion and oxygenation; however, there were conflicting results testing the association between hypercapnia and mortality.ConclusionWhile individual pre‐clinical studies identified potential mechanisms by which changes in PaCO2 levels could affect pathophysiology in sepsis, there is a paucity of clinical data as to the optimal PaCO2 range, demonstrating a need for future research.RegistrationPROSPERO number CRD42018086703.
The rise of the Red Crescent
Authors: Yurdakul Eray S. , Gunes Nuray , Namal Fatih , Coskun Ali K. , Watters David A. 
Published: December 2020

AbstractThis paper addresses the establishment of the Red Crescent, an equivalent of the Red Cross, in the Ottoman Empire in 1868 through the founding of ‘the Society of Care and Aid for Wounded and Disabled Soldiers’ (Mecrȗhȋnve Marzȃ‐yi Askeriyeye İmdad ve Muavenet Cemiyeti). Following initial slow development, the Society was revitalized in April 1877 in preparation for war with Russia. Importantly, the 1877–1878 Ottoman–Russian conflict was the first major war conducted by signatories of the 1864 First Geneva Convention, which made provisions for the treatment of wounded and sick soldiers and protection for those providing care. Although both the Ottoman Empire and Russia were signatories, major issues remained to be resolved in practice and the heat of conflict. One of the unresolved issues was international and Russian recognition of a red crescent on a white background as a sign of neutrality, in addition to a red cross. An interim agreement was signed between the two sides with international support. Full international approval of the red crescent symbol took much longer and was only confirmed at the ninth Red Cross Conference in Washington in 1912, 35 years later. Today, the red crescent represents all majority Muslim countries' aid institutions.
Cardiac sensory afferents modulate susceptibility to anxio‐depressive behaviour in a mouse model of chronic heart failure
Authors: Kermorgant Marc , Ben Salem Jennifer , Iacovoni Jason S. , Calise Denis , Dahan Lionel , Guiard Bruno P. , Lopez Sébastien , Lairez Olivier , Lasbories Antoine , Nasr Nathalie , Pavy Le‐Traon Anne , Beaudry Francis , Senard Jean‐Michel , Arvanitis Dina N 
Published: December 2020

AbstractAimImpairments in cerebral structure and cognitive performance in chronic heart failure (CHF) are critical components of its comorbidity spectrum. Autonomic afferents that arise from cardiac sensory fibres show enhanced activity with CHF. Desensitization of these fibres by local application of resiniferatoxin (RTX) during myocardial infarction (MI) is known to prevent cardiac hypertrophy, sympathetic hyperactivity and CHF. Whether these afferents mediate cerebral allostasis is unknown.MethodsCHF was induced by myocardial infarction. To evaluate if cardiac afferents contribute to cerebral allostasis, RTX was acutely applied to the pericardial space in controls (RTX) and in MI treated animals (MI/RTX). Subjects were then evaluated in a series of behavioural tests recapitulating different symptoms of depressive disorders. Proteomics of the frontal cortices (FC) was performed to identify contributing proteins and pathways responsible for behavioural allostasis.ResultsDesensitization of cardiac afferents relieves hallmarks of an anxio/depressive‐like state in mice. Unique protein signatures and regulatory pathways in FCs isolated from each treatment reveal the degree of complexity inherent in the FC response to stresses originating in the heart. While cortices from the combined treatment (MI/RTX) did not retain protein signatures from the individual treatment groups, all three groups suffer dysregulation in circadian entrainment.ConclusionCHF is comorbid with an anxio/depressive‐like state and ablation of cardiac afferents relieves the despair phenotype. The strikingly different proteomic profiles observed in FCs suggest that MI and RTX lead to unique brain‐signalling patterns and that the combined treatment, potentially through destructive interference mechanisms, most closely resembles controls.
Generalized multi‐SNP mediation intersection–union test
Authors: Zhong Wujuan , Darville Toni , Zheng Xiaojing , Fine Jason , Li Yun 
Published: December 2020

AbstractTo elucidate the molecular mechanisms underlying genetic variants identified from genome‐wide association studies (GWAS) for a variety of phenotypic traits encompassing binary, continuous, count, and survival outcomes, we propose a novel and flexible method to test for mediation that can simultaneously accommodate multiple genetic variants and different types of outcome variables. Specifically, we employ the intersection–union test approach combined with the likelihood ratio test to detect mediation effect of multiple genetic variants via some mediator (e.g., the expression of a neighboring gene) on outcome. We fit high‐dimensional generalized linear mixed models under the mediation framework, separately under the null and alternative hypothesis. We leverage Laplace approximation to compute the marginal likelihood of outcome and use coordinate descent algorithm to estimate corresponding parameters. Our extensive simulations demonstrate the validity of our proposed methods and substantial, up to 97%, power gains over alternative methods. Applications to real data for the study of Chlamydia trachomatis infection further showcase advantages of our methods. We believe our proposed methods will be of value and general interest in this post‐GWAS era to disentangle the potential causal mechanism from DNA to phenotype for new drug discovery and personalized medicine.
Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders
Authors: Xu Yang , Alfaro‐Magallanes Víctor M. , Babitt Jodie L. 
Published: December 2020

AbstractThe discovery of hepcidin has provided a solid foundation for understanding the mechanisms of systemic iron homeostasis and the aetiologies of iron disorders. Hepcidin assures the balance of circulating and stored iron levels for multiple physiological processes including oxygen transport and erythropoiesis, while limiting the toxicity of excess iron. The liver is the major site where regulatory signals from iron, erythropoietic drive and inflammation are integrated to control hepcidin production. Pathologically, hepcidin dysregulation by genetic inactivation, ineffective erythropoiesis, or inflammation leads to diseases of iron deficiency or overload such as iron‐refractory iron‐deficiency anaemia, anaemia of inflammation, iron‐loading anaemias and hereditary haemochromatosis. In the present review, we discuss recent insights into the molecular mechanisms governing hepcidin regulation, how these pathways are disrupted in iron disorders, and how this knowledge is being used to develop novel diagnostic and therapeutic strategies.
Curcumin analog B14 has high bioavailability and enhances the effect of anti‐breast cancer cells in vitro and in vivo
Authors: Shen Hui , Shen Jianfen , Pan Huan , Xu Longsheng , Sheng Han , Liu Beibei , Yao Ming 
Published: December 2020

AbstractCurcumin has a variety of anticancer properties, but low bioavailability prevents its use in chemotherapeutic applications. To address this problem, we tested the efficacy of the synthetic curcumin analog B14 in breast cancer cells and explored the mechanism by which B14 inhibits proliferation and metastasis of breast cancer cells. We used the breast cancer cell line MCF‐7, MDA‐MB‐231 to study the anticancer effects of B14 and assessed cell viability, cell migration and invasion, cell cycle, and apoptosis, in addition, the antitumor effect of B14 in vivo was examined in mice bearing MDA‐MB‐231 cells. We found that, as the concentration of B14 increased, cell viability decreased in a dose‐dependent manner. Compound B14 exerted the best antitumor activity and selectivity for MCF‐7 and MDA‐M‐231 cells (IC50 = 8.84 μmol/L and 8.33 μmol/L, respectively), while its IC50 value for MCF‐10A breast epithelial cells was 34.96 μmol/L. B14 has been shown to be a multi‐targeted drug that alters the expression of cyclin D1, cyclin E1, and cyclin‐dependent kinase 2 (CDK2), and ultimately induces G1 phase cell cycle arrest. At the same time, B14 activates the mitochondrial apoptosis pathway in breast cancer cells. Furthermore, B14 was more effective than curcumin in inhibiting cell migration, invasion, and colony formation. In tumor‐bearing mice, analog B14 significantly reduced tumor growth and inhibited cell proliferation and angiogenesis. The pharmacokinetic test found that B14 was more stable than curcumin in vivo. Our data reveal the therapeutic potential of the curcumin analog B14 and the underlying mechanisms to fight breast cancer cells.