bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation of the protective effects of Dehydroepiandrosterone (DHEA) in chemotherapatic Cyclophosphamide (CP) induced ovarian damage on rats
Authors: Sakin Önder , Alan Yasemin , Anğın Ali Doğukan , Basak Kahyan , Alan Murat 
Published: December 2019

Objective: We aimed to investigate whether cyclophosphamide-induced damage to rat ovary can be prevented by DHEA.
Material and Method: Group 1 (the control Group): no treatment was administered. Intact ovarian tissue was removed and blood samples were taken for anti-mullerian hormone (AMH) test. Group 2 (the Cyclophosphamide Group): Rats received Cyclophosphamide intraperitoneally at a single dose of 150 mg / kg. Group 3 (the Cyclophosphamide + DHEA Group): Rats received Cyclophosphamide intraperitoneally at a single dose of 150 mg / kg at baseline and DHEA subcutaneously for 10 days at a dose of 60 mg / kg daily. Rats in groups 2 and 3 were sacrificed at the end of 10 days, ovarian tissues were removed and blood samples were taken for AMH test.
Results: While normal ovarian tissue damage scores were zero, cyclophosphamide showed significant damage and histopathological changes in all rats. Cyclophosphamide group had higher vascular congestion (p=0.004) and total damage scores (p=0.010) than normal ovarian group. Cyclophosphamide + DHEA group had higher edema (p<0.001), vascular congestion (p<0.001) and total damage scores (p<0.001). Cyclophosphamide group had a decrease in primordial (p = 0.001), primary (p = 0.043) and preantral follicles(p = 0.006). Cyclophosphamide + DHEA group showed a decrease in primordial (p = 0.001) and antral follicles(p = 0.018). AMH levels did not decrease in both groups.
Conclusions: It was found that the use of DHEA to prevent Cyclophosphamide-induced ovarian damage in rats did not produce significant changes in antral follicle counts, ovarian volume, and AMH levels, which were important for clinical practice.
ANALISIS KEMAMPUAN KOMUNIKASI MATEMATIS SISWA DA-LAM MENYELESAIKAN SOAL OPEN ENDED PADA MATERI ARITMETIKA SOSIAL KELAS VII SMP
Authors: Widayanti Evi , Anggraeni Sukma Ana 
Published: December 2019

Kemampuan komunikasi matematis siswa dalam menyelesaikan soal open ended yang berkaitan dengan permasalahan sehari-hari sangatlah penting. Penelitian ini bertujuan untuk mengukur, menganalisis, dan mendeskripsikan kemampuan komunikasi matematis siswa dalam menyelesaikan soal open-ended pada materi aritmetika sosial kelas VII SMP. Jenis penelitian adalah penelitian deskriptif kualitatif. Subjek penelitian ada 36 siswa kelas VII-H di SMPN 28 Surabaya dan diambil 6 siswa dari kategori tinggi, sedang, dan rendah. Teknik pengumpulan data yang digunakan adalah tes dan wawancara. Tes berupa soal open-ended materi aritmetika sosial. Wawancara untuk menganalisis kemampuan komunikasi matematis secara lisan menggunakan wawancara semi terstruktur. Subjek dianalisis berdasarkan 3 indikator yaitu: 1) menyatakan peristiwa sehari-hari dalam bahasa atau simbol matematika (IDK 1), 2) menjelaskan ide, situasi dan relasi matematik, secara lisan dan tulisan dengan benda nyata, gambar, grafik dan aljabar (IDK 2), dan 3) menganalisis dan mengevaluasi pemikiran matematis dan strategi yang dipakai orang lain (IDK 3).
Hasil penelitian menunjukkan bahwa kemampuan komunikasi matematis siswa dalam menyelesaikan soal open-ended pada materi aritmetika sosial kelas VII SMP dapat dikatakan baik, karena (1) siswa pada kategori tinggi mampu mencapai Indikator 1 (IDK 1), IDK 2, dan IDK 3, (2) siswa pada kategori sedang mampu mencapai IDK 1 dan IDK 2, tetapi kurang mampu pada IDK 3, dan (3) siswa pada kategori rendah mampu mencapai IDK 1, kurang mampu pada IDK 2, dan belum mampu pada IDK 3.
PENGARUH KESELAMATAN DAN KESEHATAN KERJA TERHADAP KINERJA KARYAWAN BENGKEL RANGKUTI MOTOR UKUI PELALAWAN
Authors: Lamin Lamin 
Published: December 2019

ABSTRAKPENGARUH KESELAMATAN DAN KESEHATAN KERJA TERHADAP KINERJA KARYAWAN BENGKEL RANGKUTI MOTOR UKUI PELALAWAN Oleh: LAMIN, SE.MM Sekolah Tinggi Ilmu Ekonomi Riau (STIER) Jln. HR. Subrantas 57 Panam Pekanbaru 28293 Telp. (0761) 63237 E-mail: akbar_stier@yahoo.comPenelitian ini bertujuan untuk mengetahui keselamatan dan kesehatan terhadap kinerja karyawan. Dalam penelitian ini data dikumpulkan melalui kuesioner terhadap 32 orang .Teknik analisis data yang digunakan adalah analisis regresi berganda,yang berfungsi untuk membuktikan hipotesis penelitian. Hasil pengujian 1 adalah keselamatan berpengaruh signifikan terhadap kinerja karyawan dilihat dari t-hitung lebih besar dari t-tabel (4,414>2,042). Hasil pengujian 2 adalah kesehatan berpengaruh signifikan terhadap kinerja karyawan dilihat dari t-hitung lebih besar dari t-tabel (2,363>2,042). Hasil pengujian 3 keselamatan dan kesehatan berpengaruh signifikan terhadap kinerja karyawan dilihat dari tingkat signifikansi 0,00 < 0,05. Dan hasil regresi linear berganda menunjukkan Y= a + bX1+bX2 yaitu: Y=-2,340+0,623X1+0,317X2. Dari persamaan regresi tersebut disimpulkan bahwa koefisien regresi dari bx bernilai Positif. Hal ini menunjukkan variabel bebas apabila ditingkatkan persamaanya akan menimbulkan kenaikan pada variabel terikatnya. hasil R Square sebesar 0,535 (53,50%) menerangkan bahwa kinerja karyawan bengkel Rangkuti Motor Ukui dipengaruhi oleh keselamatan dan kesehatan sebesar 53,50% .Kata Kunci: Keselamatan dan Kesehatan, Kinerja Karyawan ABSTRACTEFFECT OF SAFETY AND HEALTH OF WORK ON EMPLOYEE WORK PERFORMANCE OF RANGKUTI MOTORS OF UKUI PELALAWANBy: LAMIN, SE.MMRiau School of Economics (STIER)Jln. HR. Subrantas 57 Panam Pekanbaru 28293 Tel. (0761) 63237E-mail: akbar_stier@yahoo.comThis study aims to determine the safety and health of employee performance. In this study data were collected through a questionnaire of 32 people. The data analysis technique used was multiple regression analysis, which serves to prove the research hypothesis. The result of testing 1 is that safety has a significant effect on employee performance seen from the t-test greater than t-table (4,414> 2,042). Test result 2 is that health has a significant effect on employee performance seen from the t-test greater than t-table (2,363> 2,042). The results of testing 3 safety and health have a significant effect on employee performance seen from the significance level of 0.00 <0.05. And the results of multiple linear regression shows Y = a + bX1 + bX2, namely: Y = -2.340 + 0.623X1 + 0.317X2. From the regression equation it is concluded that the regression coefficient of bx is positive. This shows that the independent variable will increase if the dependent variable increases. R Square results of 0.535 (53.50%) explained that the performance of Rangkuti Motor Ukui workshop employees was influenced by safety and health by 53.50%.Keywords: Safety and Health, Employee Performance
THE INFLUENCE OF PLAYING BALL TOWARD MOVEMENT ACTIVITY ABILITY TO HYPOACTIVE AUTISM CHILDREN
Authors: Imanniyah Anggawati 
Published: December 2019

Hypoactive autism children were indicated by slow motoric activity so that it caused the children difficult to move. The children tended passive and they did not have any interest to do movement activity and preferred alone when they looked their friends playing. To help hypoactive autism children in enhancing movement activity ability it required a game which attracted the children’s interest to move i.e. through playing game.
The purpose of this research was to analyze movement activity ability before and after giving intervention using playing ball (passing and shooting), with time allocation 10 times meeting and 8 times intervention. This research used quantitative approach with the one group pretest posttest design. The subjects were 5 hypoactive autism children. For data analysis this research used statistic non parametric formula of sign test kind and the method of data collection applied observation and test.
From the research result which was then analyzed by using sign test formula, it was obtained that the value of Z counting 1,78 while the value of Z table with critic value 5% one side test was obtained 1,64 so that Z counting 1,78 was greater than Z table1,64 it meant that null hypothesis (Ho) was refused and work hypothesis (Ha) was accepted. In this way it could be concluded that playing ball influenced toward movement activity ability of hypoactive autism children
HUBUNGAN KESEHATAN SPIRITUAL DENGAN KUALITAS HIDUP ORANG DENGAN HIV/AIDS DI YAYASAN LANTERA MINANGKABAU SUPPORT PADANG
Authors: Sastra Lenni 
Published: December 2019

Angka kejadian HIV/AIDS terus mengalami peningkatan setiap tahunnya. Permasalahan yang dihadapi orang dengan HIV/AIDS sangat kompleks. Salah satu dampak dari permasalahan adalah penurunan kualitas hidup. Kualitas hidup seseorang dapat dipengaruhi oleh kesehatan spiritual. Tujuan penelitian ini adalah untuk mengetahui hubungan antara kesehatan spiritual dengan kualitas hidup orang dengan HIV/AIDS. Jenis penelitian adalah deskriptif analitik dengan pendekatan cross sectional study. Populasi pada penelitian ini adalah orang dengan HIV/AIDS di Yayasan Lantera Minangkabau Support Padang dengan jumlah sampel sebanyak 50 orang yang diambil dengan teknik total sampling. Data dianalisis secara univariat menggunakan uji chi square dengan tingkat kepercayaan (CI) 95 % dengan nilai α = 0,05. Hasil penelitian menunjukkan lebih dari separoh (64%) orang dengan HIV/AIDS memiliki kualitas hidup buruk, 36% memiliki kualitas hidup baik, lebih dari separoh (60%) memiliki kesehatan spiritual buruk dan 40% memiliki kesehatan spiritual baik. Hasil uji statistik di dapatkan ada hubungan kesehatan spiritual dengan kualitas hidup orang dengan HIV/AIDS di Yayasan Lantera Minangkabau Support Padang. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa orang dengan HIV/AIDS dengan kesehatan spiritual buruk cenderung memiliki kualitas hidup buruk, sedangkan orang dengan HIV/AIDS dengan kesehatan spiritual baik memiliki kualitas hidup baik. Diharapkan kepada agar perawat untuk untuk meningkatkan kesehatan spiritual orang dengan HIV/AIDS agar kualitas hidup mereka bisa lebih baik lagi.
In Situ Raman Spectra of a Conical Conductive Shell as an Electro Galvanic Spin Orbit Transformer (SPOT)
Authors: Fontein Florian , Fischer Ulrich 
Published: December 2019

Experimental results are interpreted, which were obtained by tip enhanced Raman Spectroscopy (TERS) in a specific SNOM (Scanning Near-Field Optical Microscope) STM (Scanning Tunneling Microscope) configuration with a tunnel gap. The interpretation is performed in terms of a classical physical model of a photon as a vacuum phonon polariton. The metal tip is considered as a conductive infinitely thin shell of a diamagnetic electron gas. The stationary single electron tunnel current of an electron tunnel passage frequency f

tunnel

carries not the charge e but is shown to carry an energy hf

e
and an isotropic orbital angular momentum h/4π which corresponds to an isotropic transversal electron spin density of an angular frequency 2π

2

f

e
.Raman Spectroscopy, Electron Spin, Photon Spin, relativistic Quantum mechanicsThe electron spin current corresponds to an isotropic azimuthal inertial torque which acts on the photon by an increase of its energy and torque. Neglecting the influence of thermal and radiative losses of the conductive shell, the interpretation reproduces the spectroscopic results within the uncertainty of the experimental results. The photoelectric Raman spectrum of the tunnel gap can be regarded as a complex admittance spectrum which depends in a nonlinear way on the tunnel voltage, the tunnel current and the wavelength of the scattered light. The conical tunnel gap configuration can be considered as a bipolar Electro-Galvanic Spin -Orbit Transformer (SPOT) and from a thermodynamic viewpoint as a Quantum Energy Converter
Evaluation of Anti-HBs Antibody Immune Response against Hepatitis B virus in Vaccinated People in &#1072; North-eastern Bulgaria Region
Authors: Tsaneva-Damyanova Denitsa T. , Ivanova Liliya I. , Pavlova Silviya N. , Todorova Svetlana B. , Popova Tsvetelina K. 
Published: December 2019

Introduction: Hepatitis B virus (HBV) is one of the most significant human pathogens responsible for a huge number of acute and chronic liver infectious diseases worldwide.
Aim: To find the duration of post-vaccination immune response in individuals allocated to five age groups from 6 months to 20 years.
Materials and methods: All tested subjects were born between 1999 and 2018 and therefore covered by the compulsory vaccination program against hepatitis B. For the serological marker anti-HBs Ab we investigated 449 serum samples taken from ambulatory people and patients of St Marina University Hospital in Varna.
Results: A positive antibody response (anti-HBs Ab > 10 mIU/ml) was reported in 79.7% (n = 51) of the group of subjects up to one year old, in 70.0% (n = 196) of the subjects in the age range 1 year/1 month to 15 years, and in 39.3% (n = 33) of the subjects 15 years/1 month to 20 years old. Female sex had a better post-vaccination response than male sex with statistically significant relationship between sex and anti-HBs Ab titer (&chi;2 = 24.76, p <0.01).
Conclusions: Regardless of the mass immunization against HBV in Bulgaria, the relative share of chronic HBV infections does not show a downward trend. Therefore, it is very important to study the duration of the post-vaccination immune response by demonstrating the anti-HBs antibodies and to apply a booster dose from the vaccine if needed.
Effects of Chaenomeles maulei Fruit Juice on Reserpine-induced Behavioral Changes in Rats
Authors: Borisova Vesela A. , Eftimov Miroslav Tz. , Valcheva-Kuzmanova Stefka V. 
Published: December 2019

Background: The fruit juice from Chaenomeles japonica var. maulei (Mast.) Lavall,e is very rich in polyphenolic compounds.
Aim: The aim of the current study was to investigate the effects of Chaenomeles maulei fruit juice (CMFJ) on reserpine-induced beha-vioral changes in rats.
Materials and methods: The experimental design included a total of 50 animals, divided in the following groups: control, R, R+CMFJ2.5, R+CMFJ5, and R+CMFJ10. All groups except the control received a single intraperitoneal injection of reserpine while the Control group was injected with the vehicle. CMFJ was applied through an orogastric cannula at 0, 19, and 23 hours after reserpine injection at doses of 2.5 ml/kg, 5 ml/kg, and 10 ml/kg to groups R+CMFJ2.5, R+CMFJ5, and R+CMFJ10, respectively. The groups control and R received distilled water (10 ml/kg) at the same time points. The open field test (OFT) and the forced swim test (FST) were carried out. In the OFT, crossings and rearings were recorded as a measure of locomotor activity. In the FST, the immobility time served as a measure of depressive-like behavior.
Results: In the OFT, the number of crossings of rats were significantly reduced (p<0.05) by reserpine. CMFJ antagonized the effects of reserpine on rat locomotor activity. In the FST, reserpine caused an insignificant reduction of the immobility time while CMFJ reversed this effect probably by increasing the locomotor activity.
Conclusion: CMFJ reversed reserpine-induced hypokinesia in rats. This effect of CMFJ might be attributed to the polyphenols found in very high concentrations in the juice.
Socio-demographic Factors Affecting Initiation and Duration of Breastfeeding in a Culturally Diverse Area of North Eastern Greece
Authors: Tsanidou Eirini , Gougoula Vasiliki , Tselebonis Athanasios , Kontogiorgis Christos , Constantinidis Theodoros C. , Nena Evangelia 
Published: December 2019

Background: Breastfeeding is not only important for the bond between the mother and the child but is also associated with many health benefits. Socio-demographic factors have been found to be important for the initiation and longer duration of breastfeeding.&nbsp;
Aim: To record the breastfeeding characteristics and to explore possible associations with socio-cultural and demographic factors in a culturally diverse area in Greece.
Materials and methods: A questionnaire including information about breastfeeding characteristics, medical history and demographics was completed by parents of children in the primary schools of the area.
Results: The study included 700 school-age children (352 boys), mean age 9.4&plusmn;1.9 years. Breastfeeding was reported in 54.9% of them, with median (IQR) duration of 120 (range 60-360) days. Prevalence of breastfeeding was slightly higher in semi-urban areas, versus rural or urban settlements, but the duration there was significantly lower (p<0.001). Better educated mothers tended to initiate or sustain breastfeeding for a longer period; however, this difference was not statistically significant. Children of the native Muslim minority had been breastfed for a longer time (median duration 360 vs. 120 days, p<0.001), however, no difference was noted in prevalence.
Conclusion: Prevalence of breastfeeding in Greece is approximately 55%, similar to previous reports and along with duration is determined by certain socio-cultural factors.
Molecular-genetic Method for Fast Direct Detection of Staphylococcus Aureus and Methicillin Resistance in Blood Cultures and Punctures
Authors: Gergova Raina T. , Tsitou Virna-Maria S. , Mitov Ivan G. 
Published: December 2019

Background: Invasive infections caused by methicillin resistant Staphylococcus aureus and coagulase-negative staphylococci (MRSA/MRSCoN) require fast, adequate treatment.&nbsp;
The aim of this study was to develop a faster protocol for direct detection of MRSA/MRSCoN in blood cultures and in abscess punctures based on mecA and species specific identification of S. aureus by polymerase-chain reaction (PCR).
Materials and methods: We examined 77 growth-positive BACTEC blood cultures and 50 abscess punctures by routine microbiological assay and simultaneous PCR detection of MRSA/MRSCoN. The speci&#64257;city of the PCR was evaluated by using DNA from another 15 microbial species for negative controls. We determined the minimum inhibitory concentration (MIC) of oxacillin, vancomycin, tigecycline, linezolid, levofloxacin, clindamycin, and erythromycin against the S. aureus isolates using the E-test.&nbsp;
Results: In the blood cultures, the two methods detected 39.3% of MRSA, and 93.9% of MRCoNS. In the punctures, the PCR assay identified 20.9% of MRSA and 79.2% of MSSA. In the puncture cases, there were three PCR MRSA positive and culture negative samples. Screening for susceptibility to 14 antimicrobial agents demonstrated significantly higher (p<0.05) methicillin resistance in blood culture isolates than in the puncture ones (39.3% and 20.0%, respectively).&nbsp;
Conclusion: The new PCR protocol was very fast and specific. It was more sensitive in detecting MRSA from abscess punctures than the routine microbiological techniques. This protocol will speed up the right choice of empirical therapy, which is extremely important for saving patients&rsquo; lives.
Evaluating the Effectiveness of Simulation Training in Obstetrics and Gynecology, Pediatrics and Emergency Medicine
Authors: Sandeva Milena G. , Tufkova Stoilka , Ketev Kostadin , Paskaleva Diana 
Published: December 2019

Simulation training in medicine is a powerful tool for acquiring knowledge and practical skills in an environment close to the real world. Decreasing training opportunities directly on the patient tend to introduce simulations close to the real hospital environment without compromising the patient&rsquo;s safety.&nbsp;
The aim of the study was to evaluate the effectiveness of simulation training in the Medical Simulation Training Center (MSTC) at the Medical University of Plovdiv.
A prospective observational descriptive study was performed at the MSTC at Plovdiv Medical University between September 2017 and March 2019. The study included 245 respondents who participated in one or more practical simulation trainings and were surveyed.
The results of the study suggest that the knowledge, skills and attitudes of the trainees improve after training sessions. By increasing the number of visits, the self-esteem and confidence in performing the manipulation also increases, knowledge and technical performance significantly improve and mistakes are reduced. A statistically significant relationship has been demonstrated between the sequence of visits and acquired competencies (p=0.0001). There are no performance mistakes in those attending three or more times, but 16.2% of them still experience uncertainty while performing. Here, however, 83.8% performed the manipulation automatically and without mistakes.&nbsp;
Simulation training in medicine is effective and useful. It has its place in the curriculum for students and is a good tool for acquiring knowledge, skills and techniques in postgraduate education.
Study of the effect of selective inhibitor of Arginase II KUD 975 and of low doses of Acetylsalicylic acid on the functional parameters of the cardiovascular system In experimental preeclampsia
Authors: Severinova Olga V. , Gureev Vladimir V. , Zhilinkova Lyudmila A. , Lazareva Galina A. , Gureeva Anastasia V. , Lazareva Sofia S. 
Published: December 2019

Introduction: Over the past decade, preeclampsia has been the subject of an increased attention, as this complication is the most common cause of maternal mortality, triggering every third case of obstetric morbidity and taking lives of up to 50.000 young women worldwide each year. Despite a large number of ongoing studies, no clear algorithm for monitoring pregnant women with this pathology has been developed yet.
Materials and methods: The study was conducted on 220 female Wistar rats weighing 250–300 g. In the experiment, ADMA-like preeclampsia model was used.
Results and discussion: The introduction of L-NAME to the animals from the 14th till the 20th day of pregnancy causes the following disturbances: a rise in systolic and diastolic blood pressure in 1.4 and 1.5 times, an increase in proteinuria in 3.3 times and an increase in the content of fluid in the greater omentum from 44.39 ± 1.62% to 55.02 ± 1.74%, all of which correspond to the disorders in pregnant women in case of preeclampsia. The use of the selective inhibitor of arginase II KUD 975 (3mg/kg/day) in combination with acetylsalicylic acid (10mg/ kg/day) leads to a pronounced correction in the emerging changes: a decrease in systolic and diastolic blood pressure in 1.2 and 1.3 times, a decrease in proteinuria in 1.9 times and a decrease in the fluid content in the greater omentum.
Conclusion: Selective inhibitor of arginase II KUD 975 and small doses of acetylsalicylic acid have a pronounced positive effect in the correction of morphofunctional disorders in animals with ADMA-like preeclampsia.
Does Graded Reaming Affect the Composition of Reaming Products in Intramedullary Nailing of Long Bones?
Authors: Kouzelis Antonis Th , Kourea Helen , Megas Panagiotis , Panagiotopoulos Elias , Marangos Markos , Lambiris Elias 
Published: December 2019

abstract
Reaming products taken during intramedullary nailing were examined to identify possible differences in their composition depending on the reaming percentage. Reaming products were taken from 39 fresh closed tibial and femoral diaphyseal fractures in patients with an average age of 29 years. According to histology, reaming products mainly consisted of bone trabecular viable or nonviable, and bone marrow stroma. A statistically significant reverse correlation exists between viable bone mass percentage and reaming progress. Reaming 1 mm less than the minimum canal diameter provides a higher viable bone mass percentage, which might be an important factor in the bone healing process.