bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drainage Capacity and Resistance to Clogging of Porous Asphalt Concrete Based on the Water Penetration Test and Constant Head Permeability Test
Authors: Wang Hongchang , Chen Pingping , Liu Houyu , Zhou Minggang 
Published: September 2020

Abstract
Porous asphalt concrete (PAC) can decrease the risk of hydroplaning, reduce splashing and spraying, improve visibility, reduce traffic noise, and improve driving safety, but the clogging of the void affects its durable function. To investigate this, the fine aggregate was chosen as a plugging agent, and the permeability coefficients and water permeability coefficients were measured by using an asphalt mixture permeability testing device and pavement surface permeameter to simulate a multicycle drainage clogging experiment of PAC. The influence of asphalt mixture design parameters, including voids volume (VV), the nominal maximum aggregate sizes (NMASs), grading types on the drainage capacity, and resistance to clogging, was investigated. The two test results indicated that VV has a manifest influence on both drainage capacity and resistance to clogging. The NMAS has an obvious influence on resistance to clogging but no clear influence on the drainage capacity. PAC with the coarser gradation has better performance on drainage capacity and resistance to clogging. The clogging location is concentrated on the top 40 mm of the PAC-13 specimen. The fine particles with diameters of 0.15 to 2.36 mm are the key particles causing the clogging in the PAC-13 specimen. Water permeability coefficients and permeability coefficients have a very high correlation.
Control of mating plug expelling and sperm storage in Drosophila: A gynandromorph-
and mutation-based dissection
Authors: Szabad János , Peng Jing , Kubli Eric 
Published: September 2020

Introduction
In this study, we analyzed gynandromorphs with female terminalia, to dissect
mating-related female behaviors in Drosophila.

Materials and methods
We used gynandromorphs, experimentally modified wild-type (Oregon-R) females,
and mutant females that lacked different components of the female reproductive
apparatus.

Results
Many of the gynandromorphs mated but did not expel the mating plug (MP). Some of
these – with thousands of sperm in the uterus – failed to take up sperm into the
storage organs. There were gynandromorphs that stored plenty of sperm but failed to
release them to fertilize eggs. Expelling the MP, sperm uptake into the storage
organs, and the release of stored sperm along egg production are separate steps
occurring during Drosophila female fertility. Cuticle
landmarks of the gynandromorphs revealed that while the nerve foci that control MP
expelling and also those that control sperm uptake reside in the abdominal, the sperm
release foci derive from the thoracic region of the blastoderm.

Discussion and conclusion
The gynandromorph study is confirmed by analyses of (a) mutations that cause
female sterility: Fs(3)Avar (preventing egg deposition),
Tm2gs (removing germline cells),
and iab-4DB (eliminating gonad
formation) and (b) by experimentally manipulated wild-type females: decapitated or cut
through ventral nerve cord.
Sertraline in combination with sorafenib: A promising pharmacotherapy to target
both depressive disorders and hepatocellular cancer
Authors: Ozunal Zeynep Gunes , Donmez Cakil Yaprak , Isan Hatice , Saglam Esra , Aktas Ranan Gulhan 
Published: September 2020

Introduction
Hepatocellular carcinoma (HCC) is found within the first five most common tumors
worldwide. Sorafenib is an approved agent in HCC treatment. Sertraline is a selective
serotonin reuptake inhibitor. The aim of the study is to investigate the combination
of sertraline and sorafenib at hepatocellular cancer cell proliferation and
death.

Methods
HepG2 cells were treated with drugs and viability test XTT was performed. Cells
were stained with hematoxylin and eosin for histological examination or with
anti-Bcl-2 antibody and Hoechst 33258 for immunofluorescence.

Results
Viability results supported dose-dependent antiproliferative effect for both
sertraline and sorafenib. Microscopic evaluation of stained cells exerts morphological
changes.

Discussion
This is the first study to show that sorafenib and sertraline have synergistic
effect in hepatocellular cancer.
A SARS-CoV-2 vírus magyarországi megjelenésének kimutatása légúti minták retrospektív vizsgálata alapján
Authors: Szalai Bálint , Hercegh Éva , Magyar Nóra , Déri Dániel , Rózsa Mónika , Molnár Zsuzsanna , Kuti Dávid , Kis Zoltán , Szomor Katalin , Takács Mária , Barcsay Erzsébet 
Published: September 2020

Absztrakt:
Bevezetés: Magyarországon 2020. március 4-én sikerült először
kimutatni a SARS-CoV-2 jelenlétét két iráni beteg felső légúti mintájában. Az
első pozitív esetek megjelenését követően felmerült a kérdés, hogy a vírus mikor
kerülhetett be Magyarországra, esetleg okozott-e korábban megbetegedést. 2020.
március 4-ét megelőzően a kifejezetten SARS-CoV-2-vizsgálatra beküldött 224
légúti minta közül egyetlen sem bizonyult pozitívnak a fent említett 2 minta
kivételével. Célkitűzés: A Nemzeti Népegészségügyi Központ
Légúti Vírusok Nemzeti Referencia Laboratóriuma célul tűzte ki, hogy a 2020.
január 1. és 2020. április 19. között légútivírus-vizsgálatra beérkezett
mintákat visszamenőlegesen megvizsgálja az új koronavírus irányában.
Módszer: A tanulmányhoz felhasználtuk egyrészt az
influenzafigyelő szolgálatban részt vevő, virológiai mintavételezésre is felkért
(ún. sentinel) orvosok által rendszeresen vett, hetente beküldött légúti
mintákat, másrészt az egyéb, diagnosztikus céllal beérkezett beteganyagokat. A
vizsgálatokat real-time PCR-módszerrel végeztük. Eredmények: A
sentinel orvosok által beküldött 465 légúti mintából egy sem bizonyult
SARS-CoV-2-pozitívnak. Az egyéb (nem SARS-CoV-2) légúti diagnosztikus
vizsgálatra érkező 551 minta között sem találtunk március 4-e előtt vett pozitív
mintát. Következtetések: Ezen adatok alapján valószínűsíthető,
hogy az elsőként 2020. március 4-én diagnosztizált esetek előtt a SARS-CoV-2 nem
okozott klinikai tünetekkel járó fertőzést az országban. Orv Hetil. 2020;
161(38): 1619–1622.
Perhitungan Daya Roller Pada Alat Tangkap Bagan Tancap
Authors: Safingi Alamsyah  , Berbudi Wibowo  , Yaser Krisnafi  
Published: September 2020

Bagan Tancap Pangandaran merupakan alat tangkap ikan tradisional yang digunakan nelayan untuk menangkap jenis ikan pelagis kecil seperti ikan teri dan udang rebon. Teknik pengoperasianyang masih tradisional membuat bagan tancap menjadi kurang produktif dan sangat tergantung dengan kekuatan nelayan yang mengoperasikannya. Tujuan Penelitian ini yaitu untuk mengetahui jumlah daya yang diperlukan untuk mengangkat jaring dan hasil tangkapan pada saat haulling di atas bagan sehingga bisa dijadikan acuan sebagai perancangan alat bantu penarik bagan (roller). Analisis yang digunakan adalah analisis untuk mengetahui luasan struktur alat tangkap, hasil tangkapan, drag force, gaya apung dan gravitasi dimana hasil hitungan tersebut disajikan secara numerik yang kemudian digunakan sebagai dasar menentukan besaran beban yang di terima. Hasil penelitian menunjukan dimana pada Bagan Tancap yang memiliki dimensi panjang, lebar, dan tinggi berukuran 10 x 10 x 15 meter serta dengan hasil tangkapan per setting sebanyak 200 kg, roller bagan tersebut harus dapat memngangkat beban minimal sebesar 4488,4 Newton apabila beban tersebut sudah ada diatas permukaan air. Namun hasil tangkapan dan alat tangkap yang diangkat roller bagan dengan kecepatan 0,05 meter/detik menghasilkan beban sebesar 327,2 Newton pada saat di kolom perairan dengan densitas 1025 kg/m3. Maka daya minimal yang diperlukan oleh roller bagan yaitu sebesar 22,44 kW.
PAN ANTİBİYOTİK DİRENÇLİ PSEUDOMONAS (P. aeruginosa) VE STENOTROPHOMONAS’LARA (S. maltophilia) KARŞI SON SEÇENEK AJANLARDAN BİRİ OLAN KOLİSTİN (COLİSTİN)’İN IN VİTRO ETKİNLİĞİNİN ARAŞTIRILMASI
Authors: TÜRKEN Murat , YAZTÜRK Şahin , YILMAZ Mustafa , YILMAZ BOZOĞLAN Merve 
Published: September 2020

Son yıllarda nazokomial enfeksiyon
hastalıklarının artışı dikkat çekicidir.
Buna rağmen literatürlerde pan-antibiyotik dirençli bakterilerin yol açtığı
infeksiyonların tedavisinin eldeki antibiyotiklerle neredeyse imkansız olduğu
belirtilerek yeni antibiyotiklerin geliştirilmesine ve arayışına gereksinim
olduğu bildirilmiştir.

Dirençli enfeksiyonlarda, karşımıza çıkan;
Klebsiella spp., Enterobacter spp., Pseudomonas aeruginosa, Acinetobacter spp. ve son yıllarda önemi giderek artan
Stenotrophomonas maltophilia’lar
hatırlanır. Bu mikroorganizmalar, yaygın olarak kullanılan antibiyotiklere
karşı değişik mekanizmalarla direnç geliştirmekte ve neden oldukları
enfeksiyonların tedavisinde büyük sorunlar yaşanmaktadır.

Kolistin, polipetit yapılı
antibiyotiklerden olan polimiksin E grubundandır. Bu antibiyotik bakteri
hücresinin sitoplazmik membranının
permeabilitesini arttırmak suretiyle bakterisid etki gösterir, bunlar
gelişmesini tamamlanmış ve üremesi durmuş
bakterileri üzerine de etkilidirler.

Bu çalışma da Ocak 2004 ve Şubat 2007
tarihleri arasında Fırat Üniversitesi Tıp Fakültesi Mikrobiyoloji Anabilim Dalı
Laboratuvarına gönderilen örneklerden
klasik bakteriyolojik ve ID32 GN otomatize yöntemler kullanılarak tür
düzeyinde 57 Pseudomonas aeruginosa
ve 10 adet Stenotrophomonas maltophilia tanımlandı. Bu suşların
duyarlılıkları disk difüzyon ve E-testi yöntemleri kullanılarak araştırıldı.

Pseudomonas aeruginosa ve Stenotrophomonas maltophilia
türlerinin disk düfüzyon yönteminde kullanılan ATM, CAZ, FOX, CTX, IPM, MEM,
AK, CN,SXT, CİP, CXM, Amp, KF, Amc disklerinin tamamına dirençli olduğu
saptandı. Ayrıca E-testinde kullanılan PTc (Piperasilin+tazobaktam), TLc
(Tikarsilin klavunic asid), AK; (Amikasin), CİP(ciprofloksasin) ,
MP(meropenem), IP(imipenem), TZ(ceftazidim), OF(ofloksasin) striplerine karşıda
invitro olarak dirençli bulundu. Kolistin ile yapılan E-testinde ise,
Pseudomonas aeruginosa %15,7 duyarlı,
Stemotrophomonas maltophilia ise %30
duyarlı bulunmuştur.
Problems and Innovative Measures in Financial and Economic Management
Authors: Guan Hongqing 
Published: September 2020

<p align="justify">Since reform and opening-up of our country, market economy gets fast development and the enterprise marketing management mode has changed a lot. Then there is the unceasingly rich enterprise financial management and development. If the original financial concept do not change, it will be hard to adapt to the needs of economic development in the new period. So only by a careful analysis of new problems in the enterprise development, correctly judge the current situation can an enterprise survive in the change. In the face of the new situation, enterprises will encounter various financial problems in management and it is difficult to find scientific and reasonable solutions if they do not deal with them seriously. This paper synthesizes the financial problems in the process of enterprise development under the new situation and puts forward the corresponding solutions in order to provide help for the financial personnel to deal with related problems. </p>
Efficacy of radiotherapy vs. The combination of radio- and immunotherapy: a systematic review and meta-analysis
Authors: Voronova Veronika M. , Lebedeva Svetlana A. , Sekacheva Marina I. , Helmlinger Gabriel , Peskov Kirill V. 
Published: September 2020

Introduction and objectives. The combination of radiotherapy and immune checkpoint inhibitors has demonstrated antitumor activity in numerous preclinical studies and is currently being investigated in the clinical setting. This study aims to compare the efficacy of radiotherapy alone (RT) vs. the combination of radio- and immunotherapy (IT-RT) and identify the treatment regimen associated with maximal efficacy by using a meta-analysis.
Materials and methods. A systematic literature search was performed using the PubMed database and materials of the key oncology congresses. Studies reporting 1-year overall survival (OS) of patients with brain metastases undergoing IT-RT treatment were included in the analysis. Information about 1-year OS, individual patients characteristics, and treatment regimens for both IT-RT and control RT arms was extracted. Identification of the optimal treatment regimen was performed using a mixed meta-regression modeling approach. Analysis was performed using the R statistical environment (metafoR package).
Results. In total, 30 studies were identified, of which 13 reported outcomes for the control RT groups. The analysis revealed that IT inclusion into RT is associated with a significant increase in 1-year OS; given simultaneously, IT and RT demonstrated the highest efficacy with a 1-year OS of 68% (95% confidence interval (CI): 60%75%), followed by a sequential regimen: 1-year OS = 54% (95% CI: 47%61%) and RT alone: 1-year OS = 32% (95% CI: 2539%).
Conclusion. The current study demonstrates the superiority of combined IT-RT over RT alone; simultaneous IT and RT treatment is associated with the highest efficacy.
Primary-multiple gastrointestinal stromal tumor of the stomach
Authors: Fokeev S. D. , Kapitulin S. U. , Kazantseva E. S. , Belokrilova U. G. 
Published: September 2020

The result of the radical treatment for multiple gastrointestinal stromal tumors of large size (GIST) coming from the anterior wall of the stomach has been represented.
Conducted researches at the prehospital stage are not indicated on the GIST of the stomach. The GIST presence was confirmed by the immunohistochemical study.
Rehabilitation of patients after septoplasty
Authors: Gililov Vadim I. , Egorov Voktor I. 
Published: September 2020

Background. In recent years, in the general structure of the incidence of ENT organs diseases, the pathology of the nasal cavity and paranasal sinuses has firmly ranked first both in terms of visits to the clinic and in the group of patients undergoing inpatient treatment, which indicates a trend in an increase in the incidence rate. Septoplasty is one of the most commonly performed rhinological surgeries.
Aim: to analyze the effectiveness of complex treatment on the state of cerebral hemodynamics in patients with septal deviation after septoplasty.
Methods. Rehabilitation of patients was performed in several stages. Preoperative preparation included low-intensity laser exposure along with drug therapy. In this study, in order to prevent complications and activate reparative processes, patients of the main group (n=40) received additional bipolar-pulse irritative current therapy, while the control group patients (n=10) received only standard drug therapy.
Results. Patients of the main group showed an increase in treatment efficiency, a significant improvement in the clinical condition and indicators of cerebral hemodynamics compared with the control group.
Conclusion. To prevent complications and activate reparative processes in modern rehabilitation, it is necessary to integrate therapeutic measures, which can include, in addition to surgical methods, drug therapy (anti-inflammatory drugs, antihistamines, anticholinergics, etc., as well as physical factors (medicinal electrophoresis, ultraphonophoresis, laser therapy, magnetotherapy, etc.).
The comprehensive effect of sinusoidal modulated currents and decimeter-wave therapy for neurological manifestations of lumbar osteochondrosis
Authors: Gallyamov A. G. , Goldobina L. P. , Minyaeva O. V. , Valeev R. G. , Gallyamova N. A. 
Published: September 2020

Background. Comprehensive therapeutic techniques are becoming increasingly common in treatment of various diseases.
Aim: to study the comprehensive effect of decimeter-wave therapy, sinusoidal modulated current therapy for lumbar osteochondrosis with neurological manifestations.
Methods. The comprehensive effect of physiotherapeutic treatment in 69 patients with lumbar osteochondrosis and concomitant neurological manifestations was studied. All patients were divided into 2 groups depending on the leading neurological symptoms with reflex and radicular syndrome. Both groups received similar comprehensive physiotherapeutic treatment with sinusoidal modulated currents and decimeter waves.
Results. A comprehensive assessment of the therapeutic efficiency of treatment, taking into account clinical and paraclinical data, enabled to substantiate the positive results of treatment in 79.5% of patients with reflex syndromes and 69% with radicular syndromes.
Conclusion. The comprehensive application of sinusoidal modulated currents and decimeter wave therapy can be considered as a method of pathogenetic physiotherapy of patients with lumbar osteochondrosis with various neurological manifestations.
Ulnocarpal-Spanning Plate Fixation as a Novel Technique for Complex Distal Ulna Fracture
Authors: Sochol Kristen M. , Nicholson Luke T. , Ghiassi Alidad 
Published: September 2020

Case:
The patient was a 60-year-old woman with a comminuted, open distal radius and distal ulna metadiaphyseal fracture. After fixation of the distal radius, the distal ulna was unstable and crepitant with rotation and anteroposterior translation. Because of limited bone stock and poor soft tissue, we spanned the distal ulna using a wrist spanning plate. This was removed at 6 weeks postoperatively. She healed and was satisfied with her outcomes.

Conclusion:
This case describes the original use of a wrist spanning plate for a complex distal ulna fracture. Ulnocarpal-spanning plate fixation provides an alternative to traditional methods of fixation.
Management of Orthopaedic Emergencies During a Pandemic: Compartment Syndrome of the Hand in a Patient with COVID-19
Authors: Hill Kelly L. , Wu Victor J. , Kusumoto Hirofumi , Sherman William F. , Savoie Felix H. 
Published: September 2020

Case:
A 58-year-old man presented with acute respiratory distress syndrome and coagulopathy secondary to COVID-19. He developed acute compartment syndrome (ACS) of the left hand. He underwent a bedside 10-compartment decompression of the hand with volar forearm and carpal tunnel release while in the ICU. This report adds to the scarce body of literature regarding orthopaedic complications related to COVID-19.

Conclusion:
Coagulopathy secondary to COVID-19 can be a risk factor for the development of ACS. Frequent examinations of lines, restraints, and extremities are recommended. The COVID-19 pandemic presents unique challenges, necessitating clinical adjustments to best care for patients.
COVID-19 and Child Vaccination: A Systematic Approach to Closing the Immunization Gap
Authors: Olorunsaiye Comfort Z. , Yusuf Korede K. , Reinhart Kylie , Salihu Hamisu M. 
Published: September 2020

The COVID-19 pandemic threatens to set back major successes that have been achieved in global vaccine initiatives. We conducted a rapid review and synthesis of the literature on immunization provision and Utilization since the onset of the COVID-19 pandemic. A total of 11 papers comprising peer-reviewed articles and key policies and guidelines, published between January 1 and June 15, 2020, were analyzed. Widespread disruptions of routine immunization and vaccination campaigns were reported leaving millions of children worldwide at risk of measles outbreaks. We present an expanded model of the World Health Organization’s Global Routine Immunization Strategic Plan (GRISP) action areas as a tool to help countries quickly adapt to immunization challenges in the presence of COVID-19 and close the emerging immunization coverage gaps.
Key words: • Immunization • Child health • Vaccination • COVID-19 • Essential health services • Corona virus

Copyright © 2020 Olorunsaiye et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
Expected Surge in Maternal Mortality and Severe Morbidity among African-Americans in the Era of COVID-19 Pandemic
Authors: Yusuf Korede K , Dongarwar Deepa , Ibrahimi Sahra , Ikedionwu Chioma , Maiyegun Sitratullah O. , Salihu Hamisu M. 
Published: September 2020

Prior to the COVID-19 pandemic, African-American mothers were three times as likely to die from pregnancy-related causes compared to white mothers. The impact of the pandemic among African- Americans could further worsen the racial disparities in maternal mortality (MM) and severe maternal morbidity (SMM). This study aimed to create a theoretical framework delineating the contributors to an expected rise in maternal mortality (MM) and severe maternal morbidity (SMM) among African-Americans in the era of the COVID-19 pandemic due to preliminary studies suggesting heightened vulnerability of African-Americans to the virus as well as its adverse health effects. Rapid searches were conducted in PubMed and Google to identify published articles on the health determinants of MM and SMM that have been or likely to be disproportionately affected by the pandemic in African-Americans. We identified socioeconomic and health trends determinants that may contribute to future adverse maternal health outcomes. There is a need to intensify advocacy, implement culturally acceptable programs, and formulate policies to address social determinants of health.
Keywords: • COVID-19 • Maternal mortality • Severe maternal morbidity • African-Americans

Copyright © 2020 Yusuf et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
COVID-19 Devastation of African American Families: Impact on Mental Health and the Consequence of Systemic Racism
Authors: Ibrahimi Sahra , Yusuf Korede K. , Dongarwar Deepa , Maiyegun Sitratullah Olawunmi , Ikedionwu Chioma , Salihu Hamisu M. 
Published: September 2020

African Americans are bearing a disproportionate burden of morbidity and mortality due to COVID-19 pandemic. To our knowledge, no previous study has delineated inequities potentially incentivized by systemic racism, and whether synergistic effects impose an abnormally high burden of social determinants of mental health on African American families in the era of COVID-19 pandemic. We applied the social ecological model (SEM) to portray inequities induced by systemic racism that impact the mental health of African American families. In our model, we identified systemic racism to be the primary operator of mental health disparity, which disproportionately affects African American families at all levels of the SEM. Programs tailored towards reducing the disproportionate detrimental effects of COVID-19 on the mental health of African Americans need to be culturally appropriate and consider the nuances of systemic racism, discrimination, and other institutionalized biases.
Key words: • African American • COVID-19 • Mental health • Systemic racism • Social determinants of mental health

Copyright © 2020 Ibrahimi et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.