bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Intellectual Capital and Islamic Corporate Governance on Islamic Social Reporting Disclosure with Financial Performance Mediation
Authors: Budi Ichsan Setiyo , Rahmawati Prof Rahmawati Prof 
Published: November 2019

This research aimed to examine the indirect effect of Islamic Corporate Governance (ICG) disclosure and Intellectual Capital (IC) on Islamic Social Reporting (ISR) disclosure with financial performance as a mediating variable in Islamic Banking in Indonesia. It used secondary data with annual report data sources and financial statements on Islamic banking in Indonesia. They were testing this research using regression analysis with data for the annual reporting period of 2011 through 2014. The result finds that ROE mediates the effect of ICG on ISR disclosure. This shows that good management of Islamic banks will produce high financial performance so that they are able to carry out their social roles well too. The contribution of this research is to develop a new model of the role of financial performance mediating the effect of ICG disclosure on ISR so that it is beneficial for the development of science.
Remediation of groundwater contamination from an old, non-functional landfill in Hořkovec open cast mine, Czech Republic
Authors: Anvarov Adyl , Angel Adelaida Pelaez , Rando Beatriz Felices , Gil Jimena Lazaro 
Published: November 2019

Abstract
The main aim of this work was to assess different suitable strategies for the remediation of groundwater contaminated with the leachate from an old, not functional landfill located next to Hořkovec open cast mine, in the Czech Republic. The leachate consisted of mainly chlorinated aliphatic compounds and aromatic volatile compounds. The site, that had already been treated, was observed to show rebounding effects after the first remediation treatment. This article analyses the possibilities of using different types of remediation technologies that include in-situ chemical oxidation (ISCO) with different oxidants (potassium permanganate, sodium permanganate and sodium persulfate), as well as in-situ bioremediation (ISB), and the combination of both types of treatment. From the results of the analysis it was concluded that the best option for this case was to carry out a pre-treatment of the area by ISCO with sodium persulfate as the oxidant agent and then a further biological treatment.
Perspectives beyond the meter: a Q-study for modern segmentation of drinking water customers
Authors: Brouwer Stijn , Pieron Miranda , Sjerps Rosa , Etty Thijs 
Published: November 2019

Abstract
Given the growing interest among drinking water companies in the customer ‘beyond the meter’, generic accounts of the ‘average user’ no longer suffice. Yet, segmentation on the basis of specific characteristics or behaviour seems to offer a limited explanatory value. Hence, there is an increasing need for more detailed empirical knowledge of the potential for, and significance of, customer segmentation on the basis of subjective views and preferences. To this end, this paper not only explores different customer perspectives on drinking water, but also quantifies their prevalence and distribution, at a deep analytical level, in the Netherlands. The paper draws on empirical data collected from both a Q-study, encompassing a focus group and more than 30 interviews, and two large-scale surveys with a 3-year interval. We conclude that four customer perspectives on drinking water can be distinguished: (1) ‘aware & committed’; (2) ‘down to earth & confident’; (3) ‘egalitarian & solidary’; and (4) ‘quality & health concerned’. The modern customer segmentation approach in this paper offers deeper insights into the satisfaction, interests, concerns, and sociodemographic characteristics of customers related to these perspectives, which can aid companies in their quest to become more customer-oriented and responsive to different customer needs.
Application of bimetallic Al-doped ZnO nano-assembly for heavy metal removal and decontamination of wastewater
Authors: Jawed Aquib , Pandey Lalit M. 
Published: November 2019

Abstract
In the present study, bimetallic aluminium doped zinc oxide (AZO) nano-assemblies were synthesized for heavy metal removal and disinfection of wastewater. These bimetallic nanoparticles (NPs) were prepared by a simple co-precipitation method and characterized using field emission transmission electron microscopy (FETEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Brunauer–Emmett–Teller (BET), a Litesizer, and energy dispersive X-ray spectroscopy (EDS). The AZO NPs was tested for lead removal at various environmental conditions and optimized at pH 4 and 25 °C. The kinetic data were well fitted to the pseudo-second-order model and the process consisted of both surface adsorption and intraparticle diffusion. Al doping enhanced the surface charge of AZO NPs four fold as compared to ZnO, which improved colloidal stability and contributed towards its reusability. AZO NPs exhibited excellent removal efficiency of 86% over three adsorption-desorption cycles. The adsorption was found to be an exothermic and physicochemical process. The prepared AZO NPs were also used to treat a real wastewater sample and found to effectively remove Pb(II) and kill all the bacteria present.
Comparison of Profiling of Hairy Root of Two Tibetan Medicinal Plants Przewalskia tangutica Maxim. and Anisodus tanguticus Maxim
Authors: Lei Tianxiang , Wang Huan , Li Songling , Cai Xiaojian , Chen Shilong , Cheng Tingfeng , Shen Jianwei , Shi Shengbo , Zhou Dangwei 
Published: November 2019

Background:Tropane Alkaloids (TAs) are important drugs for curing many diseases in the medical industry.Methods:To sustainably exploit TA resources in endangered traditional Tibetan herbs, the hairy root (HR) systems of Przewalskia tangutica Maxim. and Anisodus tanguticus Maxim. were compared under the same culture conditions.Results:The results indicated that both the Agrobacterium rhizogenes strains and explants affected the HR induction frequency, MSU440, A4 and LBA9402 strains could induce hairy roots following infection of cotyledon and hypocotyl of A. tanguticus while LBA9402 could not induce HR on either explants of P. tangutica. The efficiency of LBA9402 was higher than A4 and MSU440 on A. tanguticus and A4 was better strain than MSU440 on P. tangutica. The hypocotyl explant was more suitable for P.tangutica and cotyledon explant was better for A.tangutica with a transformation frequency of 33.3% (P. tangutica) and 82.5% (A. tanguticus), respectively. In a flask reactor system, both the growth curves of HR for two species both appeared to be “S” curve; however, the HR of P. tangutica grew more rapidly than that of A. tanguticus, and the latter accumulated more biomass than the former. As the culture volume increased, the HR proliferation coefficient of both the species increased. HPLC analysis results showed that the content of TAs in the HR of P. tangutica was 257.24mg/100g·DW, which was more than that of A. tanguticus HR (251.08mg/100g·DW), and the anisodamine in the Pt- HR was significantly higher than that in At-HR. Moreover, tropane alkaloids in the HR of the two species were all significantly higher than that of the roots of aseptic seedlings.Conclusion:Our results suggest that HR of P. tangutica and A. tanguticus both could provide a useful platform for sustainable utilization of two Tibetan medicinal plants in the Qinghai-Tibetan Plateau in the future.
Fastidious Anatomization of Biota Procured Compounds on Cancer Drug Discovery
Authors: Thirupathi Anand , Shanmugavadivelu Chandra M. , Natarajan Sampathkumar 
Published: November 2019

Background:Natural products are the rootstock for identifying new drugs since ancient times. In comparison with synthetic drugs, they have abounding beneficial effects in bestowing protection against many diseases, including cancer. Cancer has been observed as a major threat in recent decades, and its prevalence is expected to increase over the next decades. Also, current treatment methods in cancer therapy such as radiation therapy and chemotherapy cause severe adverse side effects among the cancer population. Therefore, it is exigent to find a remedy without any side effects.Methods:In recent years, research has focused on obtaining naturally derived products to encounter this complication. The current pace of investigations, such as gene identification and advancement in combinatorial chemistry, leads to the aberrant access to a wide range of new synthetic drugs. In fact, natural products act as templates in structure predictions and synthesis of new compounds with enhanced biological activities.Results:Recent developments in genomics have established the importance of polymorphism, which implies that patients require different drugs for their treatment. This demands the discovery of a large number of drugs, but limited sources restrict the pharmaceutical industry to overcome these major obstacles. The use of natural products and their semisynthetic and synthetic analogues could alleviate these problems. However, the lack of standardization in terms of developing methods for evaluating the chemical composition, efficacy, isolation and international approval is still a major limitation in this field. In the past few years, several drug-approval authorities, including the FDA and WHO have allowed using these naturally derived compounds in humans.Conclusion:In this review, we described the use of some natural products from plant and marine sources in cancer treatment and shed some light on semi-synthetic and synthetic compounds derived from natural sources used in cancer therapy.
The Role of Endostatin in Rheumatoid Arthritis
Authors: Nijhawan Priya , Behl Tapan 
Published: November 2019

Background:
Endostatin by its therapeutic value against rheumatoid arthritis has recently
gained significant interest in biomedical science. A recent study revealed that various approaches
have been made to prevent rheumatoid arthritis by either controlling or inhibiting the progression of
angiogenesis.

Objective:
The main objective of the current manuscript is to enumerate the intrinsic role of endostatin
in rheumatoid arthritis.

Methods:
A thorough and detailed review of literature from the papers published from the year
1997-2019 was studied for the preparation of the current article.

Results:
Endostatin is one such agent of the subfamily of ECM called as multiplexins obtained
from proteolytic cleavage of XVIII and its carboxylic terminal fragments and is known for its antiangiogenic
and antiproliferative property. The exact mechanism of endostatin is still unclear, but it
acts by downregulating or inhibiting the responses of various factors, including Id1, Id3, matrix
metalloproteinase, and Nuclear factor Kappa B that are liable for angiogenesis. The mutual effects
on adipogenesis and angiogenesis, endostatin inhibits dietary-induced obesity and its related metabolic
disorders, such as insulin resistance, glucose intolerance, and hepatic steatosis.

Conclusion:
The present review demonstrates the intrinsic usage of endostatin as a novel molecule
in rheumatoid arthritis. It focuses on the status of the therapeutic potential of endostatin in inhibiting
the activity of angiogenesis is also very well explored.
Identification of Novel Key Targets and Candidate Drugs in Oral Squamous Cell Carcinoma
Authors: Liu Juan , Lian Xinjie , Liu Feng , Yan Xueling , Cheng Chunyan , Cheng Lijia , Sun Xiaolin , Shi Zheng 
Published: November 2019

Background:
Oral Squamous Cell Carcinoma (OSCC) is the most common malignant
epithelial neoplasm. It is located within the top 10 ranking incidence of cancers with a poor
prognosis and low survival rates. New breakthroughs of therapeutic strategies are therefore needed
to improve the survival rate of OSCC harboring patients.

Objective:
Since targeted therapy is considered as the most promising therapeutic strategies in
cancer, it is of great significance to identify novel targets and drugs for the treatment of OSCC.

Methods:
A series of bioinformatics approaches were launched to identify the hub proteins and
their potential agents. Microarray analysis and several online functional activity network analysis
were firstly utilized to recognize drug targets in OSCC. Subsequently, molecular docking was used
to screen their potential drugs from the specs chemistry database. At the same time, the assessment
of ligand-based virtual screening model was also evaluated.

Results:
In this study, two microarray data (GSE31056, GSE23558) were firstly selected and
analyzed to get consensus candidate genes including 681 candidate genes. Additionally, we
selected 33 candidate genes based on whether they belong to the kinases and transcription factors
and further clustered candidate hub targets based on functions and signaling pathways with
significant enrichment analysis by using DAVID and STRING online databases. Then, core PPI
network was then identified and we manually selected GRB2 and IGF1 as the key drug targets
according to the network analysis and previous references. Lastly, virtual screening was performed
to identify potential small molecules which could target these two targets, and such small
molecules can serve as the promising candidate agents for future drug development.

Conclusion:
In summary, our study might provide novel insights for understanding of the
underlying molecular events of OSCC, and our discovered candidate targets and candidate agents
could be used as the promising therapeutic strategies for the treatment of OSCC.
Economic Performance and Nutrient Use Efficiency of Onion (Allium Cepa L.) Under N, K and S Nutrient Combinations in Northern Ethiopia
Authors: Tesfay Teklay , Girmay Selamawit 
Published: November 2019

Background:Nitrogen (N), potassium (K) and sulfur (S) nutrient elements play an important role in the growth and bulb yield of onion. However, imbalanced nutrient application leads onion producers to get lower onion bulb yield. Hence, the supply of adequate and balanced plant nutrients is important in order to achieve better nutrient utilization as well as proper growth and high yield.Objective:To evaluate the agronomic and economic performance as well as nutrient efficiency of onion in response to the combined application of nitrogen, potassium and sulfur nutrient levels.Method:The field experiment was conducted during 2016/17 to test agronomic, economic and nutrient use efficiency of eighteen treatment groups with the combination of three levels of N, three levels of K and two levels of S nutrient on onion using a randomized complete block design.Results:The combined application of N, K and S nutrient levels appreciably resulted in significant variation not only on growth and bulb yield of onion but also on the economic performance and nutrient use efficiencies. Increased growth and improved bulb yield of onion as well as better nutrient uptakes and recoveries were observed in plots treated with relatively higher NKS rates. However, enhanced Agronomic Efficiency (AE) and Partial Factor Productivity (PFP) were obtained from plots treated with no N and K nutrient applications.Conclusion:Higher growth, improved bulb yield and enhanced nutrient use efficiencies (nutrient concentrations, uptakes and recoveries) were obtained from onion plants cultivated using a relatively higher NKS nutrient level. However, from the economic point of view, onion production using combined application of 69 kg N ha-1and 15 kg S ha-1was the most profitable, irrespective of the K level.
Consideraciones metodológicas para la investigación con simuladores de red
Authors: Trinidad Franco , Talay Carlos 
Published: November 2019

La simulación permite recrear escenarios para su estudio, mediante programas de computadora, sin necesidad de implementarlos en el mundo real. Esto reduce el costo de experimentación e incrementa el nivel de control que se tiene sobre un modelo de sistema. En el contexto de la investigación en redes de computadoras, los simuladores resultan muy útiles en el análisis de protocolos y componentes de red.
Uno de los problemas más estudiados es el análisis de rendimiento del protocolo TCP. En sus origines, éste sólo contemplaba pérdidas de paquetes por problemas de congestión, típicos de redes cableadas predominantes en la época. La aparición de redes inalámbricas puso de relieve falencias de TCP, al no poder responder a la multiplicidad de razones por las que éstas pierden paquetes: salidas del rango de cobertura, movilidad, interferencia de señales, etc.
Hay muchos autores que abordan las ventajas y desventajas del modelado de sistemas con enfoque de simulación, estándares para seleccionar herramientas más adecuadas, la estructura de cursos de instrucción y capacitación, y aplicaciones en ámbitos particulares. También existe una literatura amplia sobre el análisis de protocolos haciendo uso de simuladores de red, en particular NS2. Este trabajo busca integrar conocimientos adquiridos del área de redes de computadora y telecomunicaciones, con el manejo de herramientas de simulación y la experiencia en el estudio de rendimiento del protocolo TCP, para explicar algunas consideraciones metodológicas que resultan útiles en dicho emprendimiento.
LA TRATA DE PERSONAS EN COLOMBIA - HUMAN TRAFFICKING IN COLOMBIA
Authors: Solano Beltrán Jesús Alberto 
Published: November 2019

Resumen El presente estudio plantea la trata de personas en Colombia haciendo un recorrido histórico del nacimiento de esta práctica. Posteriormente se analiza la “Estrategia Nacional de Lucha Contra la Trata de Personas” en cabeza del Ministerio del Interior, siendo operacionalizada por la Policía Nacional, a través de la Dirección de Investigación Criminal e INTERPOL. Por lo anterior, en aras de realizar un análisis y mejoramiento de la misma, se evaluaron a través de diferentes instrumentos, el despliegue, y el punto de vista de los investigadores, víctimas y victimarios, proponiendo sugerencias y recomendaciones a la entidad encargada de su direccionamiento, con el fin de ser implementadas para mitigar el delito y fortalecer la atención de aquellos que han padecido este flagelo. Palabras claves: Delito transnacional, explotación, trata de personas, organización criminal. Abstract This study presents the Human Trafficking in Colombia, taking a historical tour of the birth of this practice. Subsequently, the "National Strategy to Prevent Human Trafficking " is analyzed under the Ministry of the Interior, being operationalized by the National Police, through the Directorate of Criminal Investigation and INTERPOL. Therefore, in order to carry out an analysis and improvement of it, the deployment, and the point of view of the investigators, victims and victimizers, were evaluated through different instruments, proposing suggestions and recommendations to the entity in charge of their address, in order to be implemented to mitigate the crime and strengthen the attention of those who have suffered this scourge. Keywords: Transnational crime, exploitation, trafficking in persons, criminal organization.
El cuento y las publicaciones en la enseñanza de geometría en la formación de niños y niñas
Authors: Pabón Hernández Lizet Fernanda , Vergel Mawency 
Published: November 2019

Esta investigación tuvo por objetivo analizar la influencia de la elaboración de cuentos y su publicación en procesos de formación y desarrollo de competencias en niños y niñas de instituciones de la región de frontera. Es el resultado de trabajo mancomunado entre docentes, estudiantes y padres de familia, que de alguna forma u otra apoyan la ejecución de las actividades propuestas. Se tomó como eje central utilizar los cuentos como herramienta didáctica en el aula de clase, a fin de gestionar nuevas formas con mayor impacto en el aprendizaje significativo los conceptos geométricos y bajo la modalidad de la investigación acción, se edificaron cuatro momentos, los cuales permitieron llegar a la presentación de un cuadernillo con cuentos escritos por los niños de tercero y cuarto primaria del Colegio El Carmen Teresiano, para la asignatura de tercero y cuarto. Se concluye que la elaboración de cuentos por parte de niños desarrolla el pensamiento creativo, variacional, formal, habilidades en lectoescritura, asi como desarrollo de competencias en interpretación y solución de problemas.
Dialéctica general de lo estético
Authors: Guendel Hermann 
Published: November 2019

La belleza es un requisito que exigimos los hombres para soportar la existencia dentro de la realidad. Esta belleza es condición esencial para poder transformar la existencia en vida, la burda realidad en nuestro mundo. La belleza y lo bello se forjan a través de un magnífico esfuerzo creador, revolucionario en su más profundo sentido. En este ensayo se explora el tema de lo bello y la organización de la realidad en la dirección de hacerla habitable, intentando una explicación del fenómeno estético centrada en el hombre.
Aprendizaje cooperativo, una estrategia pedagógica para la enseñanza en grupos grandes: antecedentes teóricos
Authors: Jiménez Morales Patricia 
Published: November 2019

El Aprendizaje Cooperativo (AC) es una estrategia pedagógica donde los estudiantes trabajan en grupos pequeños. Se basa en las teorías cognitivas que consideran al alumno como un sujeto social, que se desarrolla en un contexto sociocultural muy importante para su proceso de aprendizaje. Favorece el desarrollo de estructuras cognitivas superiores. El docente se convierte en un mediador que facilita el desarrollo de zonas de desarrollo próximo en el estudiante. El docente facilita al alumno ir más allá de su desarrollo real y alcanzar su desarrollo próximo o potencial. El AC puede ayudar a resolver las dificultades comunes en aulas con grupos numerosos de estudiantes y favorece la adquisición de aprendizajes significativos y el estudiante participa activamente en el proceso de enseñanza aprendizaje.
Generation Scotland - Using Electronic Health Records for Research
Authors: Campbell Archie , Edwards Rachel , Porteous David 
Published: November 2019

Background Generation Scotland is a family-based genetic epidemiology study of ~24,000 volunteers from ~7000 families recruited across Scotland with the capacity for follow-up through record linkage and re-contact. Broad consent was obtained for linkage to “medical records” for 98% of the cohort. This created a resource for investigation of the genetics of common conditions, available to researchers worldwide.
Methods Participants completed a demographic, health and lifestyle questionnaire, provided samples, and underwent detailed clinical assessment. The samples and data collected form a resource with broad consent for research on the genetics of conditions of current and projected public health importance. This has become a longitudinal dataset by linkage to routine NHS hospital, maternity, lab tests, prescribing, dentistry, and mortality data.
Results Researchers can use the linked datasets to find prevalent and incident disease cases, and healthy controls, in a stratified population. They can also do targeted recruitment of participants to new studies, including recall by genotype. We have established and validated EHR linkage, overcoming technical and governance issues in the process. Using consented data avoids some limitations of safe havens for analysis.
Genome-wide association studies (GWAS) have been done on a wide range of quantitative traits and biomarker measurements. Generation Scotland is a contributor to major international consortia and has collaborated with Dementia Platforms UK and Health Data Research UK to make the resources more widely known. There have been over 300 research collaborations, and GS data has contributed to 200 publications, with more in the pipeline.
Conclusions Generation Scotland has thoroughly tested the linkage process and is extending it to include primary care data and scanned images, with plans to collect more samples and data. The resources are available to academic and commercial researchers through a managed access process (www.generationscotland.org).