bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Report on the Special Executive Committee Meeting of the International Association for the History of Religions in Delphi
Authors: Wiebe Don 
Published: May 2020

Abstract
This essay is a report on the IAHR’s Extended Executive Committee meeting in Delphi (13-15 September 2019), and a critical account of its decision, formulated prior to that meeting, to reject the IAHR’s long-standing remit to support a scientific study of religion and religions. It is also a warning that insisting the IAHR be open to considering moral, social, political, spiritual or other cultural ideals will dismantle the only academic association committed to a scientific study of religions, transforming the IAHR into a weak, international version of the American Academy of Religion.
Xiqu in the Philippines: From Church Suppression to MegaMall Shows
Authors: Stenberg (石峻山) Josh 
Published: May 2020

Abstract
Evidence of xiqu (“Chinese opera”) in the Philippines begins in the early 16th century, when the Catholic church sought to suppress it. Despite its longevity, Philippine xiqu has not featured much in the multidisciplinary study of ethnic Chinese in the Philippines, nor as part of the global turn in xiqu research. This article, attending to the history and contemporary practice of xiqu, situates the Philippines and especially Manila firmly in the Hokkien network of Chinese theatre, especially in the period between the late nineteenth century and World War II. The Philippines were, and remain today, an important node in xiqu dissemination, transfer, and transnational evolution, as well as an integral part of the culture of the Chinese in the Philippines. The Philippine case helps break down fundamental linguistic, ethnic, and religious equations surrounding xiqu, given the genre’s syncretism, ethnic ambiguity, and non-Chinese language environment.
Two new species of Megarthrus (Coleoptera, Staphylinidae, Proteininae) from Mexican Cloud Forests
Authors: RODRÍGUEZ WILLIAM DAVID , NAVARRETE-HEREDIA JOSÉ L. , ARRIAGA-VARELA EMMANUEL , CUCCODORO GIULIO 
Published: May 2020

Two new species of Megarthrus are described from cloud forests of the Mexican state of Veracruz: M. cavianae Rodríguez, Navarrete-Heredia & Arriaga-Varela sp. nov., and Chiapas: M. chiapas Cuccodoro sp. nov. They differ from the two hitherto known Mexican species M. altivagans Bernhauer, 1929, and M. alatorreorum Rodríguez & Navarrete-Heredia, 2015, both from temperate forests of the Transmexican Volcanic Belt, by having synapomorphic features of the M. inaequalis-supergroup of species. This lineage includes all the Central and South American members of the genus, with the inclusion of these species, the distribution of the group is extend by more than 5 degree of latitude to the North. Within this lineage, the two new species share a very peculiar morphology of the male abdominal sternite VIII found elsewhere in the genus only in M. flavosignatus Bierig, 1940, and M. zunilensis Sharp, 1887, with which they form the M. zunilensis-group of species defined here.
Verifying Operational Forecasts of Land–Sea-Breeze and Boundary Layer Mixing Processes
Authors: Short Ewan 
Published: May 2020

AbstractForecasters working for Australia’s Bureau of Meteorology (BoM) produce a 7-day forecast in two key steps: first they choose a model guidance dataset to base the forecast on, and then they use graphical software to manually edit these data. Two types of edits are commonly made to the wind fields that aim to improve how the influences of boundary layer mixing and land–sea-breeze processes are represented in the forecast. In this study the diurnally varying component of the BoM’s official wind forecast is compared with that of station observations and unedited model guidance datasets. Coastal locations across Australia over June, July, and August 2018 are considered, with data aggregated over three spatial scales. The edited forecast produces a lower mean absolute error than model guidance at the coarsest spatial scale (over 50 000 km2), and achieves lower seasonal biases over all spatial scales. However, the edited forecast only reduces errors or biases at particular times and locations, and rarely produces lower errors or biases than all model guidance products simultaneously. To better understand physical reasons for biases in the mean diurnal wind cycles, modified ellipses are fitted to the seasonally averaged diurnal wind temporal hodographs. Biases in the official forecast diurnal cycle vary with location for multiple reasons, including biases in the directions that sea breezes approach coastlines, amplitude biases, and disagreement in the relative contribution of sea-breeze and boundary layer mixing processes to the mean diurnal cycle.
Atorvastatin protects against postoperative neurocognitive disorder via a peroxisome proliferator-activated receptor-gamma signaling pathway in mice
Authors: Yang Yinan , Wei Changwei , Liu Jinhu , Ma Danxu , Xiong Chao , Lin Dandan , Wu Anshi 
Published: May 2020

Objective Postoperative neurocognitive disorder (PND) is a main complication that is commonly seen postoperatively in elderly patients. The underlying mechanism remains unclear, although neuroinflammation has been increasingly observed in PND. Atorvastatin is a pleiotropic agent with proven anti-inflammatory effects. In this study, we investigated the effects of atorvastatin on a PND mouse model after peripheral surgery. Material and methods The mice were randomized into five groups. The PND models were established, and an open field test and fear condition test were performed. Hippocampal inflammatory cytokine expression was determined using ELISA. Peroxisome proliferator-activated receptor-gamma (PPARγ) expression in the hippocampus was tested using qRT-PCR and western blot analysis. Results On day 1 after surgery, inflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6 showed a significant increase in the hippocampus, with prominent cognitive impairment. Atorvastatin treatment improved cognitive function in the mouse model, attenuated neuroinflammation, and increased PPARγ expression in the hippocampus. However, treatment with the PPARγ antagonist GW9662 partially reversed the protective effects of atorvastatin. Conclusions These results indicated that atorvastatin improves several hippocampal functions and alleviates inflammation in PND mice after surgery, probably through a PPARγ-involved signaling pathway.
The impact of teleneurologists on acute stroke care at an advanced primary stroke centre
Authors: Gutovitz Scott , Leggett Jonathan , Hart Leslie , Leaman Samuel M , James Heather , Stillinger Toni 
Published: May 2020

Introduction We evaluated the impact of teleneurologists on the time to initiating acute stroke care versus traditional bedside neurologists at an advanced stroke center. Methods This observational study evaluated time to treatment for acute stroke patients at a single hospital, certified as an advanced primary stroke centre, with thrombectomy capabilities. Consecutive stroke alert patients between 1 March, 2016 and 31 March, 2018 were divided into two groups based on their neurology consultation service (bedside neurology: 1 March, 2016–28 February, 2017; teleneurology: 1 April, 2017–31 March, 2018). Door-to-tPA time and door-to-IR time for mechanical thrombectomy were compared between the two groups. Results Nine hundred and fifty-nine stroke patients met the inclusion criteria (436 bedside neurology, 523 teleneurology patients). There were no significant differences in sex, age, or stroke final diagnosis between groups ( p > 0.05). 85 bedside neurology patients received tPA and 35 had mechanical thrombectomy, 84 and 44 for the teleneurology group respectively. Door-to-tPA time (median (IQR)) was significantly higher among teleneurology (64 min (51.5–83.5)) than bedside neurology patients (45 min (34–69); p < 0.0001). There was no difference in door-to-IR times (mean ± SD) between bedside neurology (87.2 ± 33.3 min) and teleneurology (90.4 ± 33.4 min; p = 0.67). Discussion At this facility, our teleneurology services vendor was associated with a statistically significant delay in tPA administration compared with bedside neurologists. There was no difference in door-to-IR times. Delays in tPA administration make it harder to meet acute stroke care guidelines and could worsen patient outcomes.
Early and late outcomes of endovascular aneurysm repair to treat abdominal aortic aneurysm compared between severe and non-severe infrarenal neck angulation
Authors: Chinsakchai Khamin , Suksusilp Pichawat , Wongwanit Chumpol , Hongku Kiattisak , Hahtapornsawan Suteekhanit , Puangpunngam Nattawut , Moll Frans L , Sermsathanasawadi Nuttawut , Ruangsetakit Chanean , Mutirangura Pramook 
Published: May 2020

Background Abdominal aortic aneurysm with severe infrarenal neck angle (>60°) has long been thought to be an obstacle to endovascular aneurysm repair. However, some previous studies reported endovascular aneurysm repair to be safe and efficacious for treating abdominal aortic aneurysm in patients with severe neck angulation. The aim of this study was to investigate the early and late outcomes of endovascular aneurysm repair to treat abdominal aortic aneurysm compared between patients with severe and non-severe infrarenal neck angulation. Methods Fifty-four severe and 144 non-severe neck angulation patients who were treated at Siriraj Hospital (Bangkok, Thailand) during January 2010–October 2013 were recruited. The primary endpoints were intraoperative neck complications (e.g., type 1A endoleak or proximal graft migration) and immediate adjunct aortic neck procedures. The secondary endpoints included perioperative mortality, overall survival, and the proportion of patients that were reintervention-free at five years compared between the severe and non-severe groups. Results Severe angulation patients were significantly older than non-severe angulation patients (77 ± 6.3 vs. 74 ± 7.9 years; p =  0.021). The median proximal angle was significantly greater in the severe group (82° vs. 13.5°; p <  0.001). Intraoperative proximal neck complications developed in 29.6% of patients in the severe angulation group compared with 9.0% in the non-severe group ( p <  0.001). Significantly more patients in the severe group required intraoperative adjunct procedures (29.6% vs. 7.6%; p <  0.001). There was no significant difference in perioperative mortality between groups. At the five-year follow-up, there was no significant difference between groups for overall survival or the proportion of patients that remained reintervention-free. Conclusions Endovascular aneurysm repair to treat abdominal aortic aneurysm in patients with severe proximal neck angulation is technically feasible and safe Although the severe angulation group had a higher rate of intraoperative neck complications and immediate adjunct neck procedures than the non-severe group, there was no significant difference between groups for 30-day mortality, overall survival or the proportion of patients who remained reintervention-free at five years.
Evaluation of the Efficacy of Different Remineralizing Agents on Artificial Early Enamel Lesions of Primary Teeth: An In Vitro Study
Authors: Gümüş Hüsniye , Aydınbelge Mustafa , Sönmez Hayriye 
Published: May 2020

Aim: To analyze the remineralization efficacy of casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) and 8% arginine on artificial early enamel lesions on primary teeth enamel samples. Materials and Methods: In this in vitro study, artificial enamel lesions were created in 120 primary teeth. Teeth were randomly divided into 5 groups: group C: CPP–ACP paste; group CF: CPP–ACPF paste with 900 ppm flour; group A: paste with 8% arginine; group K+: 500 ppm NaF as a positive control; and group K–: deionized water as a negative control. After 4 weeks of the remineralization process, the effect of remineralization on samples of agents used the microhardness, atomic force microscope, and scanning electron microscope analyses. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS version 20.0, SPSS Inc., Chicago, IL, USA). ANOVA and Tukey Post-Hoc multiple comparison test were applied ( p < .05). Results: Increasing percentage values of the microhardness at groups C, CF, and A were significantly better than group K– ( p < .05), whereas there is no statistically significant difference with group K+ ( p > .05). The average surface roughness values of groups C and CF were similar with group K+ in AFM analysis, whereas average surface roughness values of group A were significantly higher than K+ group. Conclusion: The CPP–ACP, CPP–ACPF, and arginine are effective agents for remineralization of early childhood caries lesions.
A Faculty Development Graduate Medical Education Retreat to Teach and Address Social Determinants of Health
Authors: Martinez Johanna , Fornari Alice , VanHuse Venice , Fried Ethan , Uwemedimo Omolara T , Kim Eun Ji , Conigliaro Joseph , Yacht Andrew C 
Published: May 2020

Background: Social determinants of health (SDH) account for a large percentage of health outcomes. Therefore, ensuring providers can address SDH is paramount yet curricula in this area is limited. Aim: The authors aimed to raise awareness, identify learning opportunities, foster positive attitudes, and equip educators to implement SDH curriculum. Setting and participants: This retreat occurred at a large academic institution and had over 130 participants who represented 56 distinct training programs and over 20 disciplines. Program description: The retreat was titled “Social Determinants of Health: Walking in Your Patients’ Shoes.” The retreat was holistic and used a multidimensional approach that included traditional learning, team-based learning, reflective practice, and prompted action. Program evaluation: The evaluation of this retreat included electronic surveys and both qualitative and quantitative data. The retreat’s quality and effectiveness at improving participants’ knowledge and skill in addressing SDH was highly rated and resulted in numerous programs, including surgical and subspecialty programs reporting adopting SDH curricular and clinical workflow changes. Discussion: The retreat was successful and reached a wide and diverse set of faculty educators and can serve as an education model to the graduate medical education community on how to start to develop “physician-citizens.”
Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1
Authors: Becker Isabelle C. , Scheller Inga , Wackerbarth Lou M. , Beck Sarah , Heib Tobias , Aurbach Katja , Manukjan Georgi , Gross Carina , Spindler Markus , Nagy Zoltan , Witke Walter , Lappalainen Pekka , Bender Markus , Schulze Harald , Pleines Irina , Nieswandt Bernhard 
Published: May 2020

AbstractRearrangements of the microtubule (MT) and actin cytoskeleton are pivotal for platelet biogenesis. Hence, defects in actin- or MT-regulatory proteins are associated with platelet disorders in humans and mice. Previous studies in mice revealed that loss of the actin-depolymerizing factor homology (ADF-H) protein Cofilin1 (Cof1) in megakaryocytes (MKs) results in a moderate macrothrombocytopenia but normal MK numbers, whereas deficiency in another ADF-H protein, Twinfilin1 (Twf1), does not affect platelet production or function. However, recent studies in yeast have indicated a critical synergism between Twf1 and Cof1 in the regulation of actin dynamics. We therefore investigated platelet biogenesis and function in mice lacking both Twf1 and Cof1 in the MK lineage. In contrast to single deficiency in either protein, Twf1/Cof1 double deficiency (DKO) resulted in a severe macrothrombocytopenia and dramatically increased MK numbers in bone marrow and spleen. DKO MKs exhibited defective proplatelet formation in vitro and in vivo as well as impaired spreading and altered assembly of podosome-like structures on collagen and fibrinogen in vitro. These defects were associated with aberrant F-actin accumulation and, remarkably, the formation of hyperstable MT, which appears to be caused by dysregulation of the actin- and MT-binding proteins mDia1 and adenomatous polyposis coli. Surprisingly, the mild functional defects described for Cof1-deficient platelets were only slightly aggravated in DKO platelets suggesting that both proteins are largely dispensable for platelet function in the peripheral blood. In summary, these findings reveal critical redundant functions of Cof1 and Twf1 in ensuring balanced actin/microtubule crosstalk during thrombopoiesis in mice and possibly humans.
Does distance matter in foreign direct investment sub-national location choice? Evidence from China
Authors: Bi Yibo , Ren Zhiyi , Bao Kun 
Published: May 2020

AbstractMultinational enterprises (MNEs) make investment decisions according to the distance factors at a sub-national level. This paper made estimates using the gravity model with provincial foreign direct investment (FDI) data from 2000 to 2012 and employed three concepts of distance. Our empirical results indicate that geographic distance and cultural distance have significant negative effects on FDI flow, whereas economic distance has a significant positive effect. It suggests that FDI prefers to locate in regions that are geographically and culturally close but economically distant from the home country, which further implies that FDI in China is dominated by vertical FDI. Our findings suggest that Chinese provincial governments should place emphasis on attracting FDI from culturally close countries and provide institutional support to encourage and promote horizontal FDI.
CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments
Authors: Ekiz H. Atakan , Conley Christopher J. , Stephens W. Zac , O’Connell Ryan M. 
Published: May 2020

Abstract
Background
Single cell RNA sequencing (scRNAseq) has provided invaluable insights into cellular heterogeneity and functional states in health and disease. During the analysis of scRNAseq data, annotating the biological identity of cell clusters is an important step before downstream analyses and it remains technically challenging. The current solutions for annotating single cell clusters generally lack a graphical user interface, can be computationally intensive or have a limited scope. On the other hand, manually annotating single cell clusters by examining the expression of marker genes can be subjective and labor-intensive. To improve the quality and efficiency of annotating cell clusters in scRNAseq data, we present a web-based R/Shiny app and R package, Cluster Identity PRedictor (CIPR), which provides a graphical user interface to quickly score gene expression profiles of unknown cell clusters against mouse or human references, or a custom dataset provided by the user. CIPR can be easily integrated into the current pipelines to facilitate scRNAseq data analysis.

Results
CIPR employs multiple approaches for calculating the identity score at the cluster level and can accept inputs generated by popular scRNAseq analysis software. CIPR provides 2 mouse and 5 human reference datasets, and its pipeline allows inter-species comparisons and the ability to upload a custom reference dataset for specialized studies. The option to filter out lowly variable genes and to exclude irrelevant reference cell subsets from the analysis can improve the discriminatory power of CIPR suggesting that it can be tailored to different experimental contexts. Benchmarking CIPR against existing functionally similar software revealed that our algorithm is less computationally demanding, it performs significantly faster and provides accurate predictions for multiple cell clusters in a scRNAseq experiment involving tumor-infiltrating immune cells.

Conclusions
CIPR facilitates scRNAseq data analysis by annotating unknown cell clusters in an objective and efficient manner. Platform independence owing to Shiny framework and the requirement for a minimal programming experience allows this software to be used by researchers from different backgrounds. CIPR can accurately predict the identity of a variety of cell clusters and can be used in various experimental contexts across a broad spectrum of research areas.
An integrated software for virus community sequencing data analysis
Authors: Wang Mingjie , Li Jianfeng , Zhang Xiaonan , Han Yue , Yu Demin , Zhang Donghua , Yuan Zhenghong , Yang Zhitao , Huang Jinyan , Zhang Xinxin 
Published: May 2020

Abstract
Background
A virus community is the spectrum of viral strains populating an infected host, which plays a key role in pathogenesis and therapy response in viral infectious diseases. However automatic and dedicated pipeline for interpreting virus community sequencing data has not been developed yet.

Results
We developed Quasispecies Analysis Package (QAP), an integrated software platform to address the problems associated with making biological interpretations from massive viral population sequencing data. QAP provides quantitative insight into virus ecology by first introducing the definition “virus OTU” and supports a wide range of viral community analyses and results visualizations. Various forms of QAP were developed in consideration of broader users, including a command line, a graphical user interface and a web server. Utilities of QAP were thoroughly evaluated with high-throughput sequencing data from hepatitis B virus, hepatitis C virus, influenza virus and human immunodeficiency virus, and the results showed highly accurate viral quasispecies characteristics related to biological phenotypes.

Conclusions
QAP provides a complete solution for virus community high throughput sequencing data analysis, and it would facilitate the easy analysis of virus quasispecies in clinical applications.
Metabolic and transcriptomic analysis of two Cucurbita moschata germplasms throughout fruit development
Authors: Abbas Hafiz Muhammad Khalid , Huang He-Xun , Wang An-Jun , Wu Ting-Quan , Xue Shu-Dan , Ahmad Aqeel , Xie Da-Sen , Li Jun-Xing , Zhong Yu-Juan 
Published: May 2020

Abstract
Background
Pumpkins (Cucurbita moschata; Cucurbitaceae) are valued for their fruits and seeds and are rich in nutrients. Carotenoids and sugar contents, as main feature of pumpkin pulp, are used to determine the fruit quality.

Results
Two pumpkin germplasms, CMO-X and CMO-E, were analyzed regarding the essential quality traits such as dry weight, soluble solids, organic acids, carotenoids and sugar contents. For the comparison of fruit development in these two germplasms, fruit transcriptome was analyzed at 5 different developmental stages from 0 d to 40 d in a time course manner. Putative pathways for carotenoids biosynthesis and sucrose metabolism were developed in C. moschata fruit and homologs were identified for each key gene involved in the pathways. Gene expression data was found consistent with the accumulation of metabolites across developmental stages and also between two germplasms. PSY, PDS, ZEP, CRTISO and SUS, SPS, HK, FK were found highly correlated with the accumulation of carotenoids and sucrose metabolites, respectively, at different growth stages of C. moschata as shown by whole transcriptomic analysis. The results of qRT-PCR analysis further confirmed the association of these genes.

Conclusion
Developmental regulation of the genes associated with the metabolite accumulation can be considered as an important factor for the determination of C. moschata fruit quality. This research will facilitate the investigation of metabolic profiles in other cultivars.