bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holocene Moisture Variations in Western Arid Central Asia Inferred From Loess Records From NE Iran
Authors: Wang Qiang , Wei Haitao , Khormali Farhad , Wang Leibin , Yan Huaiyu , Xie Haichao , Wang Xin , Huang Wei , Chen Jianhui , Chen Fahu 
Published: March 2020

AbstractHolocene variations in precipitation in central and eastern arid central Asia (ACA) have been widely investigated, but the pattern in western ACA remains unclear. We present records of the stable carbon isotope composition of bulk organic matter (δ13Corg), magnetic parameters, and sediment color, from five loess‐paleosol sequences in NE Iran, in western ACA, with the aim of reconstructing Holocene precipitation. The Yellibadragh (YE) section (the thickest among the five sequences) was selected for optically stimulated luminescence (OSL) dating of the coarse‐grained quartz (63–90 μm) fraction, and its δ13Corg record was used to quantitatively reconstruct mean annual precipitation (MAP). The record indicates a dry early Holocene (~11.8–7.4 ka), with nearly constant MAP (~93 mm), followed by a wetting trend from the mid‐Holocene (~7.4 ka) onward, with the wettest period in the late Holocene (~4.0–0.0 ka, ~390 mm). The stratigraphic observations and environmental proxies support the reconstruction. The other loess profiles show stratigraphic features and trends of environmental proxies, which are similar to those of the YE profile. A dry early Holocene and wetting trend since the mid‐Holocene, with the wettest climate in the late Holocene in NE Iran, are both consistent with records from sand dunes and lake sediments from adjacent areas, and with loess records from central and eastern ACA. Comparison with loess records from monsoonal Asia supports the interpretation of a “westerly‐dominated climatic regime,” which was proposed mainly on the basis of lake sediment records from the region. Changes in solar insolation may have been responsible for the persistent wetting trend during the Holocene in western ACA.
Viscous Fingering and Preferential Flow Paths in Heterogeneous Porous Media
Authors: Tang Y. B. , Li M. , Bernabé Y. , Zhao J. Z. 
Published: March 2020

AbstractPreferential flow channeling and viscous fingering are widely observed phenomena in heterogeneous porous media from the pore scale to the core and reservoir scales. The transition from capillary to viscous fingering with increasing injection rate is also a well‐known phenomenon. Based on the previously observed visual similarity of viscous fingers and preferential single‐phase flow paths in 2‐D simulations, we postulate that these single‐ and two‐phase flow patterns should also be interrelated in 3‐D porous media. Capillary fingering is a manifestation of invasion percolation, a process restricted to the subnetwork of pores obtained from the critical path analysis. We investigated single‐phase flow channeling by applying a method similar to critical path analysis to the flow rate field and compared the subnetwork thus determined to the set of invaded pipes in drainage simulations. Our aim is to quantify the relation between preferential flow paths and viscous fingering, its dependence on pore‐scale heterogeneity and pore connectivity, and ultimately to upscale the network observations to the field scale appropriate for the engineering applications involving drainage in heterogeneous media.
Dynamic Response of the Fluid Mud to a Tropical Storm
Authors: Ge Jianzhong , Chen Changsheng , Wang Zheng Bing , Ke Keteng , Yi Jinxu , Ding Pingxing 
Published: March 2020

AbstractFluid mud (FM) is a unique sedimentary feature in high‐turbidity estuaries, where it can make a rapid contribution to morphodynamics. Insufficient field measurements and fixed‐point monitoring lead to deficient understandings of the formation, transport, and breakdown of the FM under extreme weather conditions. A field survey was conducted in the Changjiang Estuary during the period of turbidity maximum, just after Typhoon Haikui. The measurements captured the formation of the FM beneath the suspended layers, particularly around the lower reach of the North Passage. The thickness of the observed FM gradually decreased landward along the channel, with the maximum value reaching ~0.9 m. The major features of the observed storm‐induced FM were simulated using the Finite‐Volume Community Ocean Model. The results indicated that the initial appearance of the FM was the result of a typhoon‐intensified, salinity‐induced stratification in the outlet region. The subsequent landward propagation of the FM was driven by the combined effects of the FM‐induced mud surface pressure gradient force and saltwater intrusion near the bottom. Weak mixing during the subsequent neap tidal period sustained the FM as it rapidly extended into the middle region of the North Passage. This produced a large velocity shear at the interface of the FM and upper suspension layer, increasing the entrainment from the FM to the upper suspension layer. As a result of the increased tidal mixing, the FM weakened and then finally broke down in the subsequent spring tidal period.
Enhancing infrared emission of mercury telluride (HgTe) quantum dots by plasmonic structures
Authors: Yuan Shaofan , Chen Chen , Guo Qiushi , Xia Fengnian 
Published: March 2020

AbstractThe coupling of HgTe quantum dots to a gold nanobump plasmonic array can enhance the spontaneous infrared emission by a factor of five and reduce the influence of nonradiative decay channels.
Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6
Authors: Arnal-Estapé Anna , Cai Wesley L. , Albert Alexandra E. , Zhao Minghui , Stevens Laura E. , López-Giráldez Francesc , Patel Kiran D. , Tyagi Siddhartha , Schmitt Earlene M. , Westbrook Thomas F. , Nguyen Don X. 
Published: March 2020

AbstractLineage selective transcription factors (TFs) are important regulators of tumorigenesis, but their biological functions are often context dependent with undefined epigenetic mechanisms of action. In this study, we uncover a conditional role for the endodermal and pulmonary specifying TF GATA6 in lung adenocarcinoma (LUAD) progression. ImpairingGata6in genetically engineered mouse models reduces the proliferation and increases the differentiation of Kras mutant LUAD tumors. These effects are influenced by the epithelial cell type that is targeted for transformation and genetic context of Kras-mediated tumor initiation. In LUAD cells derived from surfactant protein C expressing progenitors, we identify multiple genomic loci that are bound by GATA6. Moreover, suppression ofGata6in these cells significantly alters chromatin accessibility, particularly at distal enhancer elements. Analogous to its paradoxical activity in lung development, GATA6 expression fluctuates during different stages of LUAD progression and can epigenetically control diverse transcriptional programs associated with bone morphogenetic protein signaling, alveolar specification, and tumor suppression. These findings reveal how GATA6 can modulate the chromatin landscape of lung cancer cells to control their proliferation and divergent lineage dependencies during tumor progression.
Immune-based therapies for hepatocellular carcinoma
Authors: Pinato David J. , Guerra Nadia , Fessas Petros , Murphy Ravindhi , Mineo Takashi , Mauri Francesco A. , Mukherjee Sujit K. , Thursz Mark , Wong Ching Ngar , Sharma Rohini , Rimassa Lorenza 
Published: March 2020

AbstractHepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death. The immune-rich contexture of the HCC microenvironment makes this tumour an appealing target for immune-based therapies. Here, we discuss how the functional characteristics of the liver microenvironment can potentially be harnessed for the treatment of HCC. We will review the evidence supporting a therapeutic role for vaccines, cell-based therapies and immune-checkpoint inhibitors and discuss the potential for patient stratification in an attempt to overcome the series of failures that has characterised drug development in this disease area.
Spinal cord injury in infancy: activity-based therapy impact on health, function, and quality of life in chronic injury
Authors: Argetsinger Laura C. , Singh Goutam , Bickel Scott G. , Calvery Margaret L. , Behrman Andrea L. 
Published: March 2020

Abstract
Introduction
Spinal cord injury (SCI) in infancy magnifies the complexity of a devastating diagnosis. Children injured so young have high incidences of scoliosis, hip dysplasia, and respiratory complications leading to poor health and outcomes. We report the medical history, progression of rehabilitation, usual care and activity-based therapy, and outcomes for a child injured in infancy. Activity-based therapy (ABT) aims to activate the neuromuscular system above and below the lesion through daily, task-specific training to improve the neuromuscular capacity, and outcomes for children with acquired SCI.

Case presentation
A 3-month-old infant suffered a cervical SCI from a surgical complication with resultant tetraplegia. Until age 3, her medical complications included scoliosis, kyphosis, and pneumonia. Even with extensive physical and occupational therapy, she was fully dependent on caregivers for mobility and unable to roll, come to sit, sit, stand or walk. She initiated ABT at ~3 years old, participating for 8 months. The child’s overall neuromuscular capacity improved significantly, especially for head and trunk control, contributing to major advances in respiratory health, novel engagement with her environment, and improved physical abilities.

Discussion
From injury during infancy until 3 years old, this child’s health, abilities, and complications were consistent with the predicted path of early-onset SCI. Due to her age at injury, severity and chronicity of injury, she demonstrated unexpected, meaningful changes in her neuromuscular capacity during and post-ABT associated with improved health, function and quality of life for herself and her caregivers.
Early post-transplantation factors predict survival outcomes in patients undergoing allogeneic hematopoietic cell transplantation for myelofibrosis
Authors: Jain Tania , Kunze Katie L. , Mountjoy Luke , Partain Daniel K. , Kosiorek Heidi , Khera Nandita , Hogan William J. , Roy Vivek , Slack James L. , Noel Pierre , Fauble Veena D. S. , Leis Jose F. , Sproat Lisa , Tefferi Ayalew , Patnaik Mrinal M. , Mesa Ruben A. , Palmer Jeanne 
Published: March 2020

AbstractFactors predicting allogeneic hematopoietic cell transplantation (HCT) outcomes in myelofibrosis in the early post-HCT period have not been defined thus far. We attempt to study such factors that can help identify patients at a higher risk of relapse or death. This retrospective study included 79 patients who underwent first HCT for myelofibrosis at three centers between 2005 and 2016. Univariate analysis showed that red blood cell (RBC) transfusion dependence (HR 9.02, 95% CI 4.0–20.35), platelet transfusion dependence (HR 8.17, 95%CI 3.83–17.37), 100% donor chimerism in CD33 + cells (HR 0.21, 95%CI 0.07–0.62), unfavorable molecular status (HR 4.41, 95%CI 1.87–10.39), normal spleen size (HR 0.42, 95%CI 0.19–0.94), grade ≥ 2 bone marrow fibrosis (vs. grade ≤ 1; HR 2.7, 95%CI 1.1–6.93) and poor graft function (HR 2.6, 95%CI 1.22–5.53) at day +100 were statistically significantly associated with relapse-free survival (RFS). RBC transfusion dependence and unfavorable molecular status were also statistically significant in the multivariate analysis. Patients in whom both of these factors were present had a significantly worse RFS when compared to those with one or none. While limited by a small sample size, we demonstrate the significance of transfusion dependence and molecular status at day +100 in predicting outcomes.
Coffee and digestive cancers—what do we know, and where do we go?
Authors: Loftfield Erikka , Freedman Neal D. 
Published: March 2020

SummaryCoffee drinking has been inversely associated with liver cancer consistently in prospective studies. Yet, the specific compounds underlying this association, and whether associations vary by preparation method, are unknown. Associations with other sites within the gastrointestinal tract are also unclear. A recent study by Tran et al. leverages the resources of the UK Biobank to begin answering these questions, and suggests important avenues for future work.
Decorating bacteria with self-assembled synthetic receptors
Authors: Lahav-Mankovski Naama , Prasad Pragati Kishore , Oppenheimer-Low Noa , Raviv Gal , Dadosh Tali , Unger Tamar , Salame Tomer Meir , Motiei Leila , Margulies David 
Published: March 2020

AbstractThe responses of cells to their surroundings are mediated by the binding of cell surface proteins (CSPs) to extracellular signals. Such processes are regulated via dynamic changes in the structure, composition, and expression levels of CSPs. In this study, we demonstrate the possibility of decorating bacteria with artificial, self-assembled receptors that imitate the dynamic features of CSPs. We show that the local concentration of these receptors on the bacterial membrane and their structure can be reversibly controlled using suitable chemical signals, in a way that resembles changes that occur with CSP expression levels or posttranslational modifications (PTMs), respectively. We also show that these modifications can endow the bacteria with programmable properties, akin to the way CSP responses can induce cellular functions. By programming the bacteria to glow, adhere to surfaces, or interact with proteins or mammalian cells, we demonstrate the potential to tailor such biomimetic systems for specific applications.
Sleep-dependent memory consolidation in infants protects new episodic memories from existing semantic memories
Authors: Friedrich Manuela , Mölle Matthias , Friederici Angela D. , Born Jan 
Published: March 2020

AbstractAny experienced event may be encoded and retained in detail as part of our episodic memory, and may also refer and contribute to our generalized knowledge stored in semantic memory. The beginnings of this declarative memory formation are only poorly understood. Even less is known about the interrelation between episodic and semantic memory during the earliest developmental stages. Here, we show that the formation of episodic memories in 14- to 17-month-old infants depends on sleep, subsequent to exposure to novel events. Infant brain responses reveal that, after sleep-dependent consolidation, the newly stored events are not processed semantically, although appropriate lexical-semantic memories are present and accessible by similar events that were not experienced before the nap. We propose that temporarily disabled semantic processing protects precise episodic memories from interference with generalized semantic memories. Selectively restricted semantic access could also trigger semantic refinement, and thus, might even improve semantic memory.
Social and environmental analysis of food waste abatement via the peer-to-peer sharing economy
Authors: Makov Tamar , Shepon Alon , Krones Jonathan , Gupta Clare , Chertow Marian 
Published: March 2020

AbstractReducing food waste is widely recognized as critical for improving resource efficiency and meeting the nutritional demand of a growing human population. Here we explore whether the sharing economy can provide meaningful assistance to reducing food waste in a relatively low-impact and environmentally-sound way. Analyzing 170,000 postings on a popular peer-to-peer food-sharing app, we find that over 19 months, 90t of food waste with an equivalent retail value of £0.7 million were collected by secondary consumers and diverted from disposal. An environmental analysis focused on Greater London reveals that these exchanges were responsible for avoiding emission of 87–156t of CO2eq. Our results indicate that most exchanges were among users associated with lower income yet higher levels of education. These findings, together with the high collection rates (60% on average) suggest that the sharing economy may offer powerful means for improving resource efficiency and reducing food waste.
Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes
Authors: Chong Chloe , Müller Markus , Pak HuiSong , Harnett Dermot , Huber Florian , Grun Delphine , Leleu Marion , Auger Aymeric , Arnaud Marion , Stevenson Brian J. , Michaux Justine , Bilic Ilija , Hirsekorn Antje , Calviello Lorenzo , Simó-Riudalbas Laia , Planet Evarist , Lubiński Jan , Bryśkiewicz Marta , Wiznerowicz Maciej , Xenarios Ioannis , Zhang Lin , Trono Didier , Harari Alexandre , Ohler Uwe , Coukos George , Bassani-Sternberg Michal 
Published: March 2020

AbstractEfforts to precisely identify tumor human leukocyte antigen (HLA) bound peptides capable of mediating T cell-based tumor rejection still face important challenges. Recent studies suggest that non-canonical tumor-specific HLA peptides derived from annotated non-coding regions could elicit anti-tumor immune responses. However, sensitive and accurate mass spectrometry (MS)-based proteogenomics approaches are required to robustly identify these non-canonical peptides. We present an MS-based analytical approach that characterizes the non-canonical tumor HLA peptide repertoire, by incorporating whole exome sequencing, bulk and single-cell transcriptomics, ribosome profiling, and two MS/MS search tools in combination. This approach results in the accurate identification of hundreds of shared and tumor-specific non-canonical HLA peptides, including an immunogenic peptide derived from an open reading frame downstream of the melanoma stem cell marker geneABCB5. These findings hold great promise for the discovery of previously unknown tumor antigens for cancer immunotherapy.
Regime shifts occur disproportionately faster in larger ecosystems
Authors: Cooper Gregory S. , Willcock Simon , Dearing John A. 
Published: March 2020

AbstractRegime shifts can abruptly affect hydrological, climatic and terrestrial systems, leading to degraded ecosystems and impoverished societies. While the frequency of regime shifts is predicted to increase, the fundamental relationships between the spatial-temporal scales of shifts and their underlying mechanisms are poorly understood. Here we analyse empirical data from terrestrial (n = 4), marine (n = 25) and freshwater (n = 13) environments and show positive sub-linear empirical relationships between the size and shift duration of systems. Each additional unit area of an ecosystem provides an increasingly smaller unit of time taken for that system to collapse, meaning that large systems tend to shift more slowly than small systems but disproportionately faster. We substantiate these findings with five computational models that reveal the importance of system structure in controlling shift duration. The findings imply that shifts in Earth ecosystems occur over ‘human’ timescales of years and decades, meaning the collapse of large vulnerable ecosystems, such as the Amazon rainforest and Caribbean coral reefs, may take only a few decades once triggered.
Diverse nanostructures underlie thin ultra-black scales in butterflies
Authors: Davis Alexander L. , Nijhout H. Frederik , Johnsen Sönke 
Published: March 2020

AbstractRecently, it has been shown that animals such as jumping spiders, birds, and butterflies have evolved ultra-black coloration comparable to the blackest synthetic materials. Of these, certain papilionid butterflies have reflectances approaching 0.2%, resulting from a polydisperse honeycomb structure. It is unknown if other ultra-black butterflies use this mechanism. Here, we examine a phylogenetically diverse set of butterflies and demonstrate that other butterflies employ simpler nanostructures that achieve ultra-black coloration in scales thinner than synthetic alternatives. Using scanning electron microscopy, we find considerable interspecific variation in the geometry of the holes in the structures, and verify with finite-difference time-domain modeling that expanded trabeculae and ridges, found across ultra-black butterflies, reduce reflectance up to 16-fold. Our results demonstrate that butterflies produce ultra-black by creating a sparse material with high surface area to increase absorption and minimize surface reflection. We hypothesize that butterflies use ultra-black to increase the contrast of color signals.
High energy acceptor states strongly enhance exciton transfer between metal organic phosphorescent dyes
Authors: de Vries Xander , Coehoorn Reinder , Bobbert Peter A. 
Published: March 2020

AbstractExciton management in organic light-emitting diodes (OLEDs) is vital for improving efficiency, reducing device aging, and creating new device architectures. In particular in white OLEDs, exothermic Förster-type exciton transfer, e.g. from blue to red emitters, plays a crucial role. It is known that a small exothermicity partially overcomes the spectral Stokes shift, enhancing the fraction of resonant donor-acceptor pair states and thus the Förster transfer rate. We demonstrate here a second enhancement mechanism, setting in when the exothermicity exceeds the Stokes shift: transfer to multiple higher-lying electronically excited states of the acceptor molecules. Using a recently developed computational method we evaluate the Förster transfer rate for 84 different donor–acceptor pairs of phosphorescent emitters. As a result of the enhancement the Förster radius tends to increase with increasing exothermicity, from around 1 nm to almost 4 nm. The enhancement becomes particularly strong when the excited states have a large spin-singlet character.
Deep high-temperature hydrothermal circulation in a detachment faulting system on the ultra-slow spreading ridge
Authors: Tao Chunhui , Seyfried W. E. , Lowell R. P. , Liu Yunlong , Liang Jin , Guo Zhikui , Ding Kang , Zhang Huatian , Liu Jia , Qiu Lei , Egorov Igor , Liao Shili , Zhao Minghui , Zhou Jianping , Deng Xianming , Li Huaiming , Wang Hanchuang , Cai Wei , Zhang Guoyin , Zhou Hongwei , Lin Jian , Li Wei 
Published: March 2020

AbstractCoupled magmatic and tectonic activity plays an important role in high-temperature hydrothermal circulation at mid-ocean ridges. The circulation patterns for such systems have been elucidated by microearthquakes and geochemical data over a broad spectrum of spreading rates, but such data have not been generally available for ultra-slow spreading ridges. Here we report new geophysical and fluid geochemical data for high-temperature active hydrothermal venting at Dragon Horn area (49.7°E) on the Southwest Indian Ridge. Twin detachment faults penetrating to the depth of 13 ± 2 km below the seafloor were identified based on the microearthquakes. The geochemical composition of the hydrothermal fluids suggests a long reaction path involving both mafic and ultramafic lithologies. Combined with numerical simulations, our results demonstrate that these hydrothermal fluids could circulate ~ 6 km deeper than the Moho boundary and to much greater depths than those at Trans-Atlantic Geotraverse and Logachev-1 hydrothermal fields on the Mid-Atlantic Ridge.