bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-breastfeeding stress response and breastfeeding self-efficacy as modifiable predictors of exclusive breastfeeding at 3 months postpartum: a prospective cohort study
Authors: Shiraishi Mie , Matsuzaki Masayo , Kurihara Shoko , Iwamoto Maki , Shimada Mieko 
Published: November 2020

Abstract
Background: The rate of exclusive breastfeeding at 3 months postpartum is only 50% in Japan. In order to increase this rate, we aimed to examine modifiable factors related to exclusive breastfeeding at 3 months postpartum by focusing on breastfeeding-related and psychosocial variables at 1 month postpartum. Methods: This prospective cohort study was conducted at a secondary medical care center in Osaka, Japan from February 2017 to October 2018. Demographic variables, infant feeding modality, breastfeeding-related variables, and psychosocial variables were obtained using questionnaires at 1 month postpartum. Daytime salivary cortisol levels before and after breastfeeding at 1 month postpartum were measured as a biological marker for stress responses associated with breastfeeding. Each infant’s feeding modality was re-assessed at 3 months postpartum. Multiple logistic regression analyses were performed to examine factors affecting exclusive breastfeeding at 3 months postpartum. Results: Of the 104 participants, 61 reported exclusive breastfeeding at 3 months postpartum. The following factors were significantly associated with exclusive breastfeeding at 3 months postpartum: multiparity (adjusted odds ratio, 95% confidence interval: 11.13, 2.08–59.59), having a university degree (5.25, 1.04–26.53), no plan to return to work by 6 months postpartum (0.02, 0.00–0.46), and exclusive breastfeeding (42.84, 6.05–303.52), lower cortisol level after breastfeeding (0.00, 0.00–0.02), and higher breastfeeding self-efficacy scale score (1.07, 1.00–1.14) at 1 month postpartum. In parity-specific analyses, exclusive breastfeeding (25.33, 4.75–134.98) and lower cortisol level after breastfeeding (0.00, 0.00–0.21) at 1 month postpartum in primiparous women, and lower cortisol level after breastfeeding (0.00, 0.00–0.94), higher breastfeeding self-efficacy score (1.18, 1.05–1.32), and absence of breast complications (0.09, 0.01-0.82) at 1 month postpartum in multiparous women were associated with exclusive breastfeeding at 3 months postpartum.Conclusions: Stress levels after breastfeeding, breastfeeding self-efficacy, and the presence of breast complications could be modifiable factors associated with subsequent exclusive breastfeeding. Further research is needed to examine whether approaches to reducing breastfeeding-related stress, improving breastfeeding self-efficacy, and preventing breast complications during lactation are effective to increase exclusive breastfeeding practices.
Physical therapy interventions for older people with vertigo, dizziness and balance disorders addressing mobility and participation: a systematic review
Authors: Regauer Verena , Seckler Eva , Müller Martin , Bauer Petra 
Published: November 2020

Abstract
Background: Vertigo, dizziness and balance disorders (VDB) are among the most relevant contributors to the burden of disability among older adults living in the community and associated with immobility, limitations of activities of daily living and decreased participation. The aim of this study was to identify the quality of evidence of physical therapy interventions that address mobility and participation in older patients with VDB and to characterize the used primary and secondary outcomes. Methods: A systematic search via MEDLINE (PubMed), Cochrane Library, CINAHL, PEDro, forward citation tracing and hand search was conducted initially in 11/2017 and updated in 7/2019. We included individual and cluster-randomized controlled trials and trials with quasi-experimental design, published between 2007 and 2017/2019 and including individuals ≥ 65 years with VDB. Physical therapy and related interventions were reviewed with no restrictions to outcome measurement. Screening of titles, abstracts and full texts, data extraction and critical appraisal was conducted by two independent researchers. The included studies were heterogeneous in terms of interventions and outcome measures. Therefore, a narrative synthesis was conducted. Results: A total of 20 randomized and 2 non-randomized controlled trials with 1,876 patients met the inclusion criteria. The included studies were heterogeneous in terms of complexity of interventions, outcome measures and methodological quality. Vestibular rehabilitation (VR) was examined in twelve studies, computer-assisted VR (CAVR) in five, Tai Chi as VR (TCVR) in three, canal repositioning manoeuvres (CRM) in one and manual therapy (MT) in one study. Mixed effects were found regarding body structure/function and activities/participation. Quality of life and/or falls were assessed, with no differences between groups. VR is with moderate quality of evidence superior to usual care to improve balance, mobility and symptoms. Conclusion: To treat older individuals with VDB, VR in any variation and in addition to CRMs seems to be effective. High-quality randomized trials need to be conducted to inform clinical decision making.
Attendants’ experience with the Personalized citizen assistance for social participation (APIC)
Authors: Gagnon Karine , Levasseur Mélanie 
Published: November 2020

Abstract
Background: To promote healthy aging, the social participation needs of older adults must be better met. Previous studies have shown the benefits of the Personalized citizen assistance for social participation (APIC), but few explored its influence on attendants. This study explored the assistance experience of attendants in providing the APIC to older adults with disabilities.Methods: A qualitative design inspired by a phenomenological approach was used with six female attendants who participated in individual interviews.Results: The APIC attendants felt useful, developed meaningful relationships with their older adults, and improved their self-knowledge. Attendants had the opportunity to reflect on their lives and self-aging. They contributed to older adults’ functional independence, motivation, and participation in social activities. Attendants encountered challenges related to withdrawn behavior in older adults, such as refusing to participate in activities.Conclusions: Considering the identified benefits of the APIC for attendants, further studies should explore personalized assistance to preserve older adults’ health.
Human CD133-positive hematopoietic progenitor cells enhance the malignancy of breast cancer cells
Authors: zhang zhe , zheng qing lian , liu yong hui , sun lian qing , han ping ping , wang rui , zhao jiao , hu shan , zhao xin han 
Published: November 2020

Abstract
Background: Human CD133+ hematopoietic progenitor cells (HPCs) are a specific subset of cells that can regulate tumor malignancy. However, the mechanism by which CD133+ HPCs affect the malignancy of human breast cancer has not been reported. Methods: CD133+ HPCs were isolated and purified from human umbilical cord blood (UCB) .We used in vitro culture of MCF-7 and MDA-MB-231 cell lines, and MCF-7 and MDA-MB-231 cells in nude mice to evaluate whether CD133+ HPCs affected the apoptosis, proliferation, invasion and epithelial mesenchymal transition EMT of breast cancer cells. Results: Co-culture with CD133+ HPCs, but not UCB CD133- cells, promoted the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells, accompanied by reducing in vitro spontaneous apoptosis. Co-administration of these two lines with CD133+ HPCs significantly enhanced the growth of implanted breast cancer in vivo. Furthermore, co-culture with CD133+ HPCs, enhanced the invasion of breast cancer cells, N-cadherin and Vimentin expression, but reduced E-cadherin expression in breast cancer cells. Conclusions: Our study demonstrated that CD133+ HPCs enhance the malignancy of breast cancer cells by attenuating spontaneous apoptosis and promoting the process of epithelial mesenchymal transition. These findings may provide new insights into the role of human CD133+ HPCs in breast cancer pathogenesis. Therefore, CD133+ HPCs may be a new therapeutic target for inhibiting the progression of breast cancer.
Hsa_circ_0123190 acts as a competitive endogenous RNA to regulate APLNR expression by sponging hsa-miR-483-3p in lupus nephritis
Authors: Zhang Chunyi , Gao Congcong , Di Xueqi , Cui Siwan , Liang Wenfang , Sun Wenbo , Yao Menghui , Liu Shengyun , Zheng Zhaohui 
Published: November 2020

Abstract
Background: Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs(circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, which is involved in mechanism of many diseases. However, the role of circRNA in lupus nephritis has been rarely reported. In this study, we aim to investigate the clinical value of circRNAs and explore the mechanism of circRNA involvement in the pathogenesis of LN. Methods: Renal tissues from three untreated LN patients and three normal controls (NCs) were used to identify differently expressed circRNAs by next-generation sequencing (NGS). Validated assays were used by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The interactions between circRNA and miRNA, or miRNA and mRNA were further determined by luciferase reporter assay. The extent of renal fibrosis between the two groups was assessed by Masson-trichome staining and immunohistochemistry (IHC) staining. Results: 159 circRNAs were significantly dysregulated in LN patients compared with NCs. The expression of hsa_circ_0123190 was significantly decreased in renal tissues of patients with LN (P =0.014). Bio-informatic analysis and luciferase reporter assay illustrated that hsa_circ_0123190 can act as a sponge for hsa-miR-483-3p, which was also validated to interact with APLNR. APLNR mRNA expression was related with chronicity index (CI) of LN (P =0.033, R 2 =0.452). Moreover, the fibrotic-related protein, transforming growth factor-β1 (TGF-β1), which was regulated by APLNR, was more pronounced in the LN group (P =0.018). Conclusion: Hsa_circ_0123190 may function as a ceRNA to regulate APLNR expression by sponging hsa-miR-483-3p in LN.
Predictors of three-month mortality among hospitalized older adults in Togo
Authors: GBEASOR-KOMLANVI Fifonsi Adjidossi , TCHANKONI Martin Kouame , BAKOUBAYI Akila Wimima , LOKOSSOU Matthieu Yaovi , SADIO Arnold , ZIDA-COMPAORE Wendpouiré Ida Carine , DJIBRIL Mohaman , BELO Mofou , AGBONON Amegnona , EKOUEVI Didier Koumavi 
Published: November 2020

Abstract
Background: Assessing hospital mortality and its predictors is important as some of these can be prevented through appropriate interventions. Few studies have reported hospital mortality data among older adults in sub-Saharan Africa. The objective of this study was to assess the mortality and associated factors among hospitalized older adults in Togo.Methods: We conducted a prospective cohort study from February 2018 to September 2019 among patients ≥50 years admitted in medical and surgical services of six hospitals in Togo. Data were recorded during hospitalization and through telephone follow-up survey within 90 days after admission. The main outcome was all-cause mortality at 3 months. Survival curves were estimated using the Kaplan-Meier method and Cox regression analyses were performed to assess predictors of mortality.Results: The median age of the 650 older adults included in the study period was 61 years, IQR: [55-70] and at least one comorbidity was identified in 59.7% of them. The all-cause mortality rate of 17.2% (95%CI: 14.4-20.4) and the majority of death (93.7%) occurred in hospital. Overall survival rate was 85.5% and 82.8% after 30 and 90 days of follow-up, respectively. Factors associated with 3-month mortality were the hospital level in the health pyramid, hospitalization service, length of stay, functional impairment, depression and malignant diseases.Conclusion: Togolese health system needs to adjust its response to an aging population in order to provide the most effective care.
Evaluation of the Therapeutic Effect of Lycoramine on Alzheimer’s Disease in Mouse Model
Authors: Kiris Irem , Basar Merve Karayel , Sahin Betul , Gurel Busra , Coskun Julide , Mroczek Tomasz , Baykal Ahmet Tarik 
Published: November 2020

Background::
Alzheimer’s disease is one of the leading health problems characterized
by the accumulation of Aβ and hyperphosphorylated tau that account for the senile
plaque formations causing extensive cognitive decline. Many of the clinical diagnoses
of Alzheimer’s disease are made in the late stages, when the pathological changes
have already progressed.

Objective::
The objective of this study is to evaluate the promising therapeutic effects of a
natural compound, lycoramine, which has been shown to have therapeutic potential in
several studies and to understand its mechanism of action on the molecular level via differential
protein expression analyses.

Method::
Lycoramine and galantamine, an FDA approved drug used in the treatment of
mild to moderate AD, were administered to 12 month-old 5xFAD mice. Effects of the
compounds were investigated by Morris water maze, immunohistochemistry and label-
free differential protein expression analyses.

Results::
Here we demonstrated the reversal of cognitive decline via behavioral testing
and the clearance of Aβ plaques. Proteomics analysis provided in-depth information on
the statistically significant protein perturbations in the cortex, hippocampus and cerebellum
sections to hypothesize the possible clearance mechanisms of the plaque formation
and the molecular mechanism of the reversal of cognitive decline in a transgenic mouse
model. Bioinformatics analyses showed altered molecular pathways that can be linked
with the reversal of cognitive decline observed after lycoramine administration but not
with galantamine.

Conclusion::
Lycoramine shows therapeutic potential to halt and reverse cognitive decline
at the late stages of disease progression, and holds great promise for the treatment of
Alzheimer’s disease.
The Potential Clinical Properties of Magnesium
Authors: Crisponi Guido , Fanni Daniela , Nurchi Valeria Marina , Cappai Rosita , Zoroddu Maria Antonietta , Gerosa Clara , Piras Monica , Faa Gavino 
Published: November 2020

:
A significant percentage of costs in pharmaceutical markets is devoted to supplements
due to the confidence of consumers in the beneficial effects of these products.
Magnesium is one of the supplements with enduring and increasing popularity. According
to what is reported online, this metal ion can cure or prevent almost all kinds of diseases.
This review aims at illustrating a series of scientifically demonstrated cases in
which magnesium was used in clinical practice. Except for its ordinary use as antacid
and laxative, other ascertained uses, reported in scientific literature, consist of helping to
treat several diseases such as nocturnal leg cramps, pre-eclampsia, diabetes, depression,
Parkinson’s and Alzheimer’s disease, hypertension, some types of arrhythmias, asthma,
migraine headaches, epilepsy, cerebral haemorrhage, and stroke.

:
However, many of these promising uses of magnesium require further studies to define
the involved molecular mechanisms which should help establishing its uses in relation to
the prolonged use of supplements.
Effects of Probiotic Preparations on Inflammatory Cytokines in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis
Authors: Liu Ting , Wang Xiaoxia , Li Rui , Zhang Zi Yuan , Fang Jingai , Zhang Xiaodong 
Published: November 2020

Objective:
To summarize and assess the effects of probiotic preparations on inflammatory
cytokine levels in patients with Chronic Kidney Disease (CKD).

Methods:
We searched through the PubMed, Cochrane Library, Embase, Web of Science, China National
Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and Wan
Fang databases for Randomized Controlled Trials (RCTs) that report the impact of probiotic preparations
on inflammatory cytokines in CKD patients. Outcomes were composed of serum levels of CReactive
Protein (CRP), Interleukin 6 (IL-6), Tumor Necrosis Factor-α (TNF-α), serum urea, creatinine,
uric acid, Para-Cresol Sulfate (PCS), and Indoxyl-Sulfate (IS). The Mean Differences (MDs)
with 95% Confidence Intervals (CIs) were considered as effect estimates. Sensitivity analysis and Egger’s
linear regression test were performed to evaluate the stability of results and publication bias. This
study was registered with PROSPERO number CRD42020176557.

Results & Discussion:
Sixteen studies met the inclusion criteria. Evidence showed that serum CRP
levels were decreased in the intervention group (WMD, -12.29, 95% CI, -16.41 to -8.16, p = 0). The
IL-6 was significantly reduced only in the prebiotic group (SMD, -0.73, 95% CI, -1.3 to -0.16, p =
0.012). However, no reduction was observed in TNF-α (SMD, -0.07, 95% CI, -0.51 to 0.38, p = 0.772).
Moreover, there was no significant change in serum uremic toxin, including creatine, urea, uric acid,
PCS, and IS.

Conclusions:
Probiotic preparations decrease the serum levels of inflammatory cytokines in CKD patients
but do not affect the serum uremic toxin levels. The results of this meta-analysis suggest essential
guidance for treatment decisions in clinical practice.
The Investigation into Neurotoxicity Mechanisms of Nonylphenol: A Narrative Review
Authors: Lotfi Mandana , Hasanpour Amir Hosseyn , Moghadamnia Ali Akbar , Kazemi Sohrab 
Published: November 2020

Background:
Nonylphenol (NP), a chemical compound widely used in industry, is the
result of the nonylphenol ethoxylate decomposition and it is known as an estrogen-like compound.
Numerous studies and researches have shown that it has many destructive functions of various organs
such as the brain. This toxicant causes oxidative stress in the cortex and hippocampus cells,
which are two essential regions to preserve memory and learning in the brain.

Methods:
This review examines recent findings to better understanding the mechanisms of NP
neurotoxicity. We used Scopus, Google Scholar, and PubMed databases to find articles focused on
the destructive effects of NP on the oxidative stress pathway and its defense mechanisms.

Results:
NP has potential human health hazards associated with gestational, peri- and postnatal
exposure. NP can disrupt brain homeostasis in different ways, such as activation of inflammatory
factors in brain especially in hippocampus and cortex, disruption of the cell cycle, changes in neuron,
dendrites and synapses morphology, disruption of extra and intracellular calcium ion balance
and also memory and learning disorders.
1'-methylspiro[indoline-3,4'-piperidine] Derivatives: Design, Synthesis, Molecular Docking and Anti-tumor Activity Studies
Authors: Li Junjian , Ye Lianbao , Wang Yuanyuan , Liu Ying , Jin Xiaobao , Li Ming 
Published: November 2020

Background:
Spirocyclic indoline compounds widely exist in numerous natural products
and synthetic molecules with significant biological activities. In recent years, these kinds of compounds
have attracted extensive attention as potent anti-tumor agents in the fields of pharmacology
and chemistry.

Objective:
In this study, we focused on designing and synthesizing novel 1'-methylspiro[indoline-
3,4'-piperidine] derivatives, which were evaluated by preliminary bioactivity experiment in vitro
and molecular docking.

Methods and Materials:
The key intermediate 1'-methylspiro[indoline-3,4'-piperidine] (B4) reacted
with benzenesulfonyl chloride with different substituents under alkaline condition to obtain its derivatives
(B5-B10). We evaluated their antiproliferative activities against A549, BEL-7402 and HeLa
cell lines by MTT assay. We performed the CDOCKER module in Accelrys Discovery Studio 2.5.5
for molecular docking of compound B5, and investigated the binding modes of compound B5 with
three different target proteins.

Results:
The results indicated that compounds B4-B10 exhibited good antiproliferative activities
against the above three types of cell lines, in which compound B5 with chloride atom as electronwithdrawing
substituent on a phenyl ring showed the highest potency against BEL-7402 cell lines
(IC50=30.03±0.43 μg/mL). The results of molecular docking showed that the binding energies of the
prominent bioactive compound B5 with CDK, c-Met, and EGFR protein crystals are -44.3583
kcal/mol, -38.3292 kcal/mol, -33.3653 kcal/mol, respectively.

Conclusion:
1'-methylspiro[indoline-3,4'-piperidine] and its six derivatives were synthesized and
evaluated against BEL-7402, A 549, and Hela cell lines. Compound B5 showed significant inhibition
on BEL-7402 cell lines. Molecular docking assays revealed that B5 as a ligand showed strong
affinity and appropriate binding pose on the amino acid residues in active sites of the tested targets,
which encourage us to conduct further evaluation such as the kinase experiment.
Prevalence of Intestinal Parasitic Infections Among Diarrheic Patients from Ahvaz, Southwestern Iran
Authors: Karami Saina , Beiromvand Molouk , Kohansal Kobra 
Published: November 2020

Background:
Intestinal parasitic infections are one of the most common infections in humans, particularly in re-source-poor communities. Gastrointestinal parasites, specially protozoa can lead to diarrhea, malabsorption, and anemia. The majority of parasitic diarrhea is caused by Entamoeba histolytica, Giardia duodenalis, and Cryptosporidium spp.
The present study aimed to evaluate the prevalence of intestinal parasites among diarrheic patients referred to the Shahid Rajaee Polyclinic, Ahvaz, southwestern Iran.

Methods:
A cross-sectional study was conducted to determine the prevalence of intestinal parasites among 250 diarrheic pa-tients using direct smear, formalin-ether concentration, ziehl- neelsen, and trichrome staining.

Results:
The results indicated that 34.4% (86/250) of the patients were infected with pathogenic parasites. Giardia duode-nalis with an occurrence of 18.8% (47/250) and Cryptosporidium spp. with a frequency of 2.8% (7/250) had the highest and lowest infection rates, respectively. Blastocystis hominis with a frequency of 15.2% (38/250) showed the highest prevalence rate after G. duodenalis. Entamoeba histolytica/dispar was observed in 3 (1.2%) of diarrheic patients. The age group 1−10 years old was the most frequently infected group (27.9%). We could not find a significant association between the source of drinking water and intestinal parasitic infections (p= 0.912).

Conclusions:
This study demonstrated that G. duodenalis was the predominant parasite found among the patients. The re-sults revealed that intestinal parasites were one of the main health problems in the region.