bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANTIRECESSIONARY ORGANIZATIONAL-ECONOMIC APPROACHES TO FUNDING OF DEVELOPMENT
Authors: Ivanisov V. Y. 
Published: October 2020

The crisis of the developers of science intensive defense articles concerns with the loss of the companies’ scientific-manufacturing potential during the reforms of the domestic economics. Restoration of the scientific-manufacturing potential of the developers of science intensive defense articles is complicated by some facts including that the state customer of the development employs organizational-economic approaches to the development funding that doesn’t correspond to the development features. Organizational-economic approaches to the development funding used by the state customer create the prerequisites for their low profitability and unprofitableness, i.e. are “crisis”. Organizational-economic approaches to the development funding are realized through the contract management system of the development on the setting of the state contracts funding volume. It means that the contract management system of the development regarding funding (and price formation) and setting of manufacturing-property conditions doesn’t correspond to the development as a managed object. That inconsistency is one of the most important prerequisites of current crisis state of the science intensive products developers. Crisis state of the science intensive products developers shows up primarily in the decline of the quality and low profitability of the science intensive defense articles. The article shows antirecessionary organizational-economic approaches to funding and establishment of manufacturing-property conditions of the defense articles development that correspond to the development features, provide state support of the scientific-manufacturing potential of the developers of science intensive defense articles, provide antirecessionary development management and should be reflected in the contract management system of the development.
Clinical and functional characteristics of remission and rehabilitation of patients with schizophrenia
Authors: Petrova Natalia N. , Lugovskaia Liubov V. 
Published: October 2020

The aimof this study was to evaluate real social functioning of patients in remission of paranoid schizophrenia in the dynamics of treatment and rehabilitation measures.
Methods.Patients of the medical rehabilitation department were included in the transverse clinical and population study. Clinical scale evaluation was used, including PANSS, PSP.
Results.It was shown that patients with schizophrenia included in the program of therapeutic and rehabilitative measures, met clinical and functional criteria of remission. Negative symptomatology prevailed in the clinical picture and was more present in male patients. Individual negative symptoms were associated with the effectiveness of rehabilitation. Despite the generally comparable level of social functioning in patients of different sexes, functioning in different spheres is mediated by the gender factor. Factors associated with the social functioning of patients include employment, experience of own family and independent living. As a result of treatment and rehabilitation measures, there is a tendency to decrease the severity of positive and negative symptoms, a reliable decrease in the severity of depressive symptoms and an increase in the level of social functioning of patients.
Conclusions.The clinical and functional characteristics of schizophrenia remission are gender-specific. Differentiated assessment of patients social functioning should include professional and microsocial adaptation. The criteria for evaluation of the effectiveness of treatment and rehabilitation measures in remission of schizophrenia include reduction of the severity of residual symptoms and increase in the level of social functioning of patients.
Quality of life in patients with multicentric breast cancer
Authors: Petrovsky A. V. , Chgan L. , Sobolevsky V. A. , Krokhina O. V. , Valiev R. K. , Nechushkin M. I. , Rumyantsev A. A. , Amosova V. A. 
Published: October 2020

One of the main issues in the treatment of multicentric breast cancer (BC) is to choose the type of surgery (paying attention to the tendency to reduce the volume of surgical interventions). Many studies have demonstrated an adverse effect of this form of BC on long‑term survival outcomes (increased risk of recurrence, decreased overall survival rates, etc.). However, none of the studies examined the effect of surgery extent on the quality of life of these patients.Objective. To assess the effect of the surgery type on the quality of life of patients with multicentric BC.Materials and methods. 190 patients were included in the study. The median follow‑up was 72 (7–116) months. Age ranged from 27 to 76 years. The majority of patients (150 women, 78.9 %) had luminal HER2‑negative tumors, while «aggressive» (HER2‑overexpressing, triple negative) subtypes were detected in 40 (21.1 %) of them. 134 patients underwent radical mastectomy (40 of which also had immediate breast reconstruction), 56 received breast‑conserving surgery. Statistically significant differences were not observed among stages III and I–II BC (p = 0.125). The quality of life was assessed with the use of EORTC QLQ-C30 and EORTC QLQ-BR23 scales at ≥ 12 months after performing surgical treatment.Results. The quality of life was assessed depending on the type of surgical intervention. The patients after breastconserving surgery and immediate breast reconstruction demonstrated a significant advantage, primarily in the general perception of one's own health (p < 0.05) and emotional status (p < 0.05). Also, there were no significant differences in quality of life between the groups of patients after breast‑ conserving surgery and immediate breast reconstruction.Conclusion. Due to the increase in the life expectancy of breast cancer patients, the issues of maintaining a high quality of life are becoming increasingly important. From this point of view, performing breast‑ conserving and reconstructive surgeries is preferable for patients with multicentric BC.
Assessing the Elevation of Cardiac Biomarkers and the Severity of COVID-19 Infection: A Meta-analysis
Authors: Walker Cucnhat , Deb Subrata , Ling Hua , Wang Zhe 
Published: October 2020

ABSTRACT - Purpose: Since December 2019, coronavirus disease 2019 infection has become a global pandemic. The cases of Coronavirus Disease 2019 (COVID-19)-related acute cardiac injury with unknown pathophysiologic mechanism has become increasingly prevalent. However, it is not yet understood how the extent of cardiac injury differs with the intensity of viral infection. In the current study, we aimed to assess the association between elevated cardiac biomarkers and the severity of COVID-19 infection. Methods: A systematic literature search was performed across PubMed and Embase databases from December 1, 2019 to July 10, 2020, to identify studies that reported cardiac biomarkers of troponin (TnI) and creatine kinase-myocardial band (CK-MB) in patients with COVID-19. These studies compared non-severe patients with severe patients, or survivors with non-survivors or medical patients with critically ill patients. The data were extracted for TnI, CK-MB, N-terminal-brain natriuretic peptide (NT-BNP), D-dimer, and lactate dehydrogenase (LDH), C-reactive protein (CRP), and interleukin 6 (IL-6). Wherever possible, the data were pooled for meta-analysis (Review Manager, RevMan. version 5.3) with standard or weighted mean or median difference and corresponding 95% confidence intervals (95% CI). Results: A total of 25 studies involving 5,626 patients were included in the present analysis. More severe COVID-19 infection was found to be associated with higher mean values of TnI (-0.54 [-0.72, -0.36]) (ng/mL), CK-MB (-1.55 [-2.23, -0.88]) (ng/mL) and (-4.75 [-13.31, 3.82]) (units/L), NT-BNP (-815.7 [-1073.97, -557.42]) (pg/mL), D-dimer (-1.4 [-2.04, -0.77]) (mcg/mL), and LDH (-176.59 [-224.11, -129.06]) (units/L), as well as CRP (-64.03 [-68.88, -59.19]) (mg/L) and IL-6 (-22.59 [-29.39, -15.79]) (pg/mL). Conclusions: There is significant association between elevated cardiac biomarkers and the severity of COVID-19, which underlines the increased risk of acute cardiac injury with more severe viral infection. This highlights the need to understand the cardiac history among the COVID-19 patients during initial assessment and for monitoring.
Miguel, Miguel: a dobra do nome
Authors: Montoril del Castilo Luís Heleno , Azevedo de Jesus Stélio Rafael 
Published: October 2020

O presente artigo tem por objetivo analisar e interpretar a novela Miguel, Miguel, de Haroldo Maranhão e a relação da dobra do nome Miguel como uma questão de linguagem literária. A literatura tem o privilégio de não estar presa às regras da verdade histórica, pois a imaginação opera como elemento essencial que subverte a lógica exigida pelo real e instaura a ambiguidade. Assim, pode-se inferir que o duplo articula-se com a palavra para recriar no mundo do texto o espelho que reflete a diferença, abstraída da repetição do nome. Nessa perspectiva, Filosofia e literatura se entrecruzam para pensar a narrativa complexa de Haroldo Maranhão.
Assessment of occupational violence towards pharmacists at practice settings in Nigeria
Authors: KHALID Garba M. , IDRIS Umar I. , JATAU Abubakar I. , WADA Yusuf H. , ADAMU Ya'u , UNGOGO Marzuq A. 
Published: October 2020

Background: Occupational Violence is prevalent among healthcare workers, including pharmacists, and poses a big threat to their job satisfaction, safety, and social wellbeing.
Objective: This study seeks to assess the incidents and factors associated with occupational violence towards pharmacists in Nigeria.
Methods: A cross-sectional study was conducted among pharmacists practicing in Nigeria, using an online survey (Google FormTM). Occupational violence was assessed using a validated questionnaire. The survey was conducted and reported based on the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Participants were recruited by sharing the survey link via social media platforms including WhatsApp, Facebook, LinkedIn, and Twitter.
Results: A total of 263 respondents returned the online questionnaire, with a completion rate of 99.2%. The prevalence of occupational violence was 92.7% (95% CI, 90 to 96). Violent events occurred among 48.7% of pharmacists with at least six years of experience, and 68.4% of hospital pharmacists. The commonly reported factors associated with the violence include long waiting times in the pharmacy (36.5%), refusal to fulfil aggressor’s demands (22.1%), and counseling/poor communication (21.7%). Events related to verbal abuse were reported among 95% of the participants. The prevalence of violence was significantly higher among hospital pharmacists, compared with those practicing in administration/regulatory, and in community pharmacies (chi-square=10.213 (2); p=0.006). Similarly, physical aggression was higher among hospital pharmacists (chi-square=10.646 (2), p = 0.005).
Conclusions: The prevalence of occupational violence towards pharmacists practicing in Nigeria appeared to be high. Major factors associated with the violence were refusal to fulfil aggressors’ demands and frustrations due to long waiting times at pharmacy. Recommended strategies to slowdown the incidences of violence were improved pharmacists’ workforce, interprofessional harmony, and penalties against perpetrators.
Research on the Development of Accounting Internal Audit System of Listed Companies
Authors: Zhang Junnan 
Published: October 2020

<p>With the rapid development of China’s market economy, listed companies are the backbone of China’s national economic growth and economic structure optimization, and they promote the continuous development of China’s economy. However, in order to better adapt to the development needs of today’s society and the needs of social and economic system construction, China’s listed companies have begun to effectively adjust their internal management systems, especially most of them have started to adjust their financial management systems in detail. This paper analyzes the problems existing in the internal audit of listed companies in China, and puts forward corresponding countermeasures.</p>
Effects of CO2/Rock/Formation Brine Parameters on CO2 Injectivity for Sequestration
Authors: Md Yusof Muhammad Aslam , Ibrahim Mohamad Arif , Idress Mazlin , Idris Ahmad Kamal , Saaid Ismail Mohd , Rosdi Nadhirah Mohd , Mohsin M. Saiful , Matali Awangku Alizul Azhari Awangku 
Published: October 2020

SummaryThe injection of carbon dioxide (CO2) into saline aquifers is highlighted as an effective technique to permanently secure anthropogenic gas produced from high CO2 gas fields in the Southeast Asia region. However, previous studies indicate that CO2 injectivity can be impaired primarily due to the interactions between CO2/brine/rock. In this paper, we investigate the effect of a CO2 injection scheme, rock permeability, brine type, and salinity on CO2 injectivity, which is presented by permeability alteration. A CO2 coreflood experiment and the characterization of the rock and effluent produced are presented. Furthermore, core samples with different permeabilities of the typical geological storage for sequestration were selected and analyzed using X-ray fluorescence (XRF), X-ray diffraction (XRD), and field-emission scanning electron microscopy equipped with energy dispersive X-ray spectroscopy (FESEM-EDX). The cores were then saturated with synthetic brine composed of 6,000, 30,000 or 100,000 parts per million (ppm) of either sodium chloride (NaCl), potassium chloride (KCl), or calcium chloride (CaCl2). Subsequently, the core samples were injected by either supercritical CO2 (scCO2), CO2-saturated brine, or CO2-saturated brine followed by scCO2. The fines particles from the collected effluent were separated for further analysis. The results indicate that a CO2 injection scheme, injection flow rate, brine salinity, and initial rock permeability are the principal factors that contribute to the permeability alteration of the core samples. It was also found from FESEM-EDX analysis of the produced fines that the precipitated salt, silica grains, and kaolinite migrated during scCO2 injection, suggesting the dissolution and precipitation of minerals. This phenomenon led to the migration of particles, some of which plugged the pore spaces and reduced the permeability. Besides, the core saturated with CaCl2 brine was the only sample with improvement in permeability after the CO2 flooding experiment.
AChE-activity in critically ill patients with suspected septic encephalopathy: a prospective, single-centre study
Authors: Zujalovic Benedikt , Mayer Benjamin , Hafner Sebastian , Balling Florian , Barth Eberhard 
Published: October 2020

Abstract
Background Up to 70% of septic patients develop a diffuse brain dysfunction named “septic associated encephalopathy” which is often solely based on clinical impressions. However, the diagnosis of septic associated encephalopathy is outcome-relevant due to an increase in mortality in these patients. Neuroinflammation as well as a disturbance of cholinergic transmission are assumed to be the causes of both delirium and septic associated encephalopathy. An alteration in cholinergic activity can be objectified by measuring the erythrocytic acetylcholinesterase-activity. Single-point measurements of acetylcholinesterase-activity are of limited value because individual and dynamic changes over time have to be anticipated. Therefore, the hypothesis should be tested whether a longitudinal analysis of acetylcholinesterase-activity in critically ill patients can help to diagnose a suspected septic-associated encephalopathy and whether acetylcholinesterase-activity differs in comparison to non-septic patients.Methods In this prospective, observational, single-center study, 175 patients (45 with sepsis, 130 without sepsis) were included. All patients were admitted to the surgical Intensive Care Unit of the University hospital Ulm, Germany. Patients were examined daily for the presence of delirium using the CAM-ICU. Daily measurement of the acetylcholinesterase-activity was performed in all patients. The possible time-dependent change in acetylcholinesterase-activity was analyzed with a linear regression model considering repeated measurements. Using a time-adjusted model further factors able to affect AChE-activity were investigated. For nonparametric distributions quantitative data were compared using Wilcoxon matched-pairs test. For analysis of independent samples the Mann-Whitney test was performed.Results About 90% of septic patients with suspected septic associated encephalopathy exhibited a statistically significant time-dependent in- or decrease in acetylcholinesterase-activity over a period of at least 5 consecutive days.Conclusion Longitudinal measurement of acetylcholinesterase-activity over several consecutive days revealed a change from baseline only in septic patients with suspected septic-associated encephalopathy. Therefore, longitudinal measurement of acetylcholinesterase-activity is able to diagnose septic associated encephalopathy in septic patients with delirious symptoms.Trial registration Retrospectively registered at German Clinical Trials Register, registration number DRKS 00020542, date of registration: January 27, 2020
Evaluation of liver function using liver parenchyma, spleen and portal vein signal intensities during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI
Authors: Yang Ming , Zhang Yue , Zhao Wenlu , Cheng Wen , Wang Han , Guo Shengren 
Published: October 2020

Abstract
Background: Previous studies have used signal intensity (SI) to reflect liver function. However, few studies have evaluated liver function via the portal vein. Regarding the SI of the liver, spleen, and portal vein, no study has indicated which can best reflect liver function. Therefore, the aim of this study is to investigate whether these parameters can evaluate liver function in patients with cirrhosis and determine which is the best parameter.Methods: 120 patients with normal livers (n = 41) or Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) disease who had undergone Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed. Comparisons of the MRI data (liver parenchyma SI, portal vein SI, and spleen SI and liver-to-portal vein contrast ratio (LPC), liver-to-spleen contrast ratio (LSC), and portal vein-to-spleen contrast ratio (PSC)) in the 15-min hepatobiliary phase images were performed among the groups, and the correlations among the liver function parameters (total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, platelet count, prothrombin time and international normalized ratio), liver function scores and MRI data were also quantitatively analysed.Results: Significant differences were observed in the liver parenchyma SI, LPC and LSC among the groups. These values all decreased gradually from normal livers to Child–Pugh class C cirrhotic livers (P < 0.001). The portal vein SI constantly and slightly increased from normal livers to Child–Pugh class C cirrhotic livers, but no differences were found among the groups in the portal vein SI and PSC (P > 0.05). LPC showed a stronger correlation with the Child–Pugh score and MELD score than LSC and the liver parenchyma SI. The order of the AUCs of these parameters, from largest to smallest, was as follows: LPC, LSC, and liver parenchyma SI (P > 0.05).Conclusion: The liver parenchyma SI, LSC and LPC may be used as alternative imaging biomarkers to assess liver function, while the portal vein SI and PSC do not reflect liver function. Furthermore, LPC values can more effectively distinguish severity among patients with cirrhosis than the liver parenchyma SI and LSC.
Assessment of Water, Sanitation and Hygiene Service Availability in Healthcare Facilities in the Greater Kampala Metropolitan Area, Uganda
Authors: Kayiwa Denis , Mugambe Richard K. , Mselle Jane Sembuche , Isunju John Bosco , Ssempebwa John C. , Wafula Solomon Tsebeni , Ndejjo Rawlance , Kansiime Winnie K , Nalugya Aisha , Wagaba Brenda , Zziwa Jude. B. , Bwire Constance , Buregyeya Esther , Radooli Martin Othieno , Kimbugwe Ceaser , Namanya Emily , Bateganya Najib Lukooya , McGriff Joanne A. , Wang Yuke , Ssekamatte Tonny , Yakubu Habib 
Published: October 2020

Abstract
Background: Improved Water, Sanitation and Hygiene (WASH) in Healthcare facilities (HCFs) is of significant public health importance. It is associated with a reduction in the transmission of healthcare acquired infections (HAIs), increased trust and uptake of healthcare services, cost saving from infections averted, increased efficiency and improved staff morale. Despite these benefits, there is limited evidence on availability of WASH services in HCFs in the Greater Kampala Metropolitan Area (GKMA). This study assessed the availability of WASH services within HCFs in the GKMA in order to inform policy and WASH programming.Methods: A cross-sectional study was conducted in 60 HCFs. Availability of WASH services in the study HCFs was assessed using a validated WASH Conditions (WASHCon) tool comprising of structured interviews, HCF observations and microbial water quality analysis. Data were analysed using Stata 14 software and R software. Results: Overall, 84.5% (49/58) and 12.1% (7/58) of HCFs had limited and basic WASH service respectively. About 48.3% (28/58) had limited water service, 84.5% (49/58) had limited sanitation service, 50.0% (29/58) had limited environmental cleanliness service, 56.9% (33/58) had limited hand hygiene service, and 51.7% (30/58) had limited waste management service. About 94.4% of public HCFs had limited WASH service compared to only 68.2% of private not for profit facilities. More health centre IIIs, 92.5% and health centre IVs (85.7%) had limited WASH service compared to hospitals (54.5%).Conclusions: Our findings indicate that provision of water, sanitation, hand hygiene, environmental cleanliness, and health care waste management services within HCFs are largely hindered by structural and performance limitations. In spite of these limitations, it is evident that environmental cleanliness and treatment of infectious waste can be attained with better oversight and dedicated personnel. Attaining universal WASH coverage in HCFs will require deliberate and strategic investments across the different domains.
Haemagglutinin displayed on the surface of Lactococcus lactis confers broad cross-clade protection against different H5N1 viruses in chickens
Authors: Lei Han , Gao Tong , Cen Qianhong , Peng Xiaojue 
Published: October 2020

Abstract
BackgroundThe highly pathogenic avian influenza (HPAI) H5N1 virus poses a potential threat to the poultry industry. The currently available avian influenza H5N1 vaccines for poultry are clade-specific. Therefore, an effective vaccine for preventing and controlling H5N1 viruses belonging to different clades needs to be developed.ResultsRecombinant L. lactis/pNZ8148-Spax-HA was generated, and the influenza virus haemagglutinin (HA) protein of A/Vietnam/1203/2004 (H5N1) was displayed on the surface of Lactococcus lactis (L. lactis). Spax was used as an anchor protein. Chickens vaccinated orally with unadjuvanted L. lactis/pNZ8148-Spax-HA could produce significant humoral and mucosal responses and neutralizing activities against H5N1 viruses belonging to different clades. Importantly, unadjuvanted L. lactis/pNZ8148-Spax-HA conferred cross-clade protection against lethal challenge with different H5N1 viruses in the chicken model.ConclusionThis study provides insights into the cross-clade protection conferred by unadjuvanted L. lactis/pNZ8148-Spax-HA, and the results might help the establishment of a promising platform for the development of a safe and effective H5N1 cross-clade vaccine for poultry.