bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological Features and Prognosis of Gastric Neuroendocrine Neoplasms
Authors: Wang Yajie , Wen Bei , Tian Shubo , Dong Kangdi , Liu Yuan , Zhang Hui , Li Leping 
Published: July 2020

Abstract
Purpose: We performed a retrospective study to investigate the relationship between clinicopathological features and prognosis of G-NEN.Methods: Clinicopathological features and follow-up data of 67 patients with G-NEN treated at Shandong Provincial Hospital affiliated of Shandong University were analyzed retrospectively. Results: This whole cohort included 53 males and 14 females, with a mean age of 59.37±9.80 years. The clinical symptoms and the primary tumor site were not specific. Neuroendocrine tumor, neuroendocrine carcinoma, and mixed neuroendocrine–non‐neuroendocrine neoplasm accounted for 14.93%, 59.70%, and 25.37%, respectively. TNM stages Ⅰ-Ⅳ: 6, 6, 49, 4, respectively. All patients underwent surgically treated. Forty-five patients underwent laparoscopic surgery, and twenty-two patients received an open approach. The median survival time was 36 months in all patients. The overall survival rate for the entire cohort was 68.1 %, 44.7 %, and 34.5% at 1, 3, and 5 years, respectively. Logistic regression analysis revealed that the invasive depth of tumors was predictors for metastasis. The univariate analysis confirmed that smoking, T stage, distant metastasis, and surgical method were related to survival. COX regression analysis showed that the T stage (HR=4.817, 95%CI: 1.021-22.729, P=0.047) was an independent risk factor for evaluating the prognosis of patients with G-NEN.Conclusions: G-NEN is a kind of rare tumors that can occur at any part of the stomach. The clinical features are not specific. The tumor invasive depth related to tumor metastasis. The prognosis is associated with smoking, T stage, distant metastasis, and surgical method. Of them, T stage is an independent prognostic factor for G-NEN patients. But larger studies are needed in the future.
Infant’s safety in cesarean section surgery: a meta-synthesis
Authors: Ghafouri Raziyeh , Yaghmaei Minoo , Khodadadi Sepideh 
Published: July 2020

Abstract
Background Patient safety is the most important clinical priority, especially in high-risk groups such as infants. Neonatal safety after a C-section is more challenging because despite all efforts and guidelines, patient safety is still a major challenge in the operating room. This meta-synthesis study aimed to investigate the factors affecting neonatal safety during a C-section and to provide improved strategies. Methods This systematic review was carried out through meta-synthesis. A total of 112 articles were found and finally, 37 articles were selected for research after review. The articles were first reviewed by title and abstract and those which met the inclusion criteria were entered into the study. The inclusion criteria were papers in English and Persian, relevance to neonatal safety and being published before 2019. Exclusion criteria were papers that were not relevant to safety or neonate. In the next step, the quality of the articles was reviewed simultaneously by two separate researchers using the Strengthening the Reporting of Observational studies in Epidemiology" STROBE" and consolidated standards of reporting t rials "CONSORT" Review Guidelines. Data were analyzed using content analysis. Results The most important risk factors of neonatal safety during a C-section included anemia due to early cord clamping, jaundice due to delayed cord clamping, nosocomial infection, hypothermia and hyperthermia, inappropriate positioning of the infant, fall, medication error, operative damage and error in registering infants identity. Conclusion For improvement of neonatal safety during C-section, it is important to consider teamwork, team and interdisciplinary continuous training through simulation, accurate identification of mothers and accurate registration of mothers and infants' identity on the identification band, accurate medication and right dosage, safely carrying and sleeping, observing infection control tips, maintaining operating room temperature and humidity, cord clamping after 30 seconds before birth and 2 minutes after birth.
Successful treatment of a critically ill patient with COVID-19 using tocilizumab and human umbilical cord mesenchymal stem cells: a case report
Authors: Ye Lei , Wen Ji-Qiu , He Song-Qing , Xu Yong-Chun , Hong Yuan-Cheng , Wang Fang-Yu , Liu Jiong 
Published: July 2020

Abstract
Background

A worldwide outbreak of coronavirus disease 2019 (COVID-19) has drawn global attention. However, up to now, no standard and effective therapy are available.

Case presentation

A 62-year-old man with a history of hypertension and diabetes was diagnosed with COVID-19 pneumonia. He suffered from obvious shortness of breath and severe hyoxemia. Normal treatments like supportive therapy and antiviral drugs didn’t seem to improve his conditions. Then, he was given tocilizumab and human umbilical cord mesenchymal stem cells. After that, his respiratory symptoms and lung infectious lesions gradually subsided, and he was successfully discharged eventually.

Conclusions

For critically ill COVID-19 patients, immunological treatment like tocilizumab human umbilical cord mesenchymal stem cells should be considered.
EFFECT OF CISPLATIN ON HEMOSTASIS IN EXPERIMENTAL ANIMALS
Authors: Filonova M. V. , Fedorova E. P. , Dubskaya T. Yu. , Neupokoeva O. V. , Churin A. A. 
Published: July 2020

Introduction. Thrombotic complications caused by the tumor and consequences of its treatment are the leading causes of death in cancer patients. The development of a model for the pathology of hemostasis, in particular the excessive pathological clot formation, in the laboratory animals receiving antitumor agents, could help find new pharmacological methods for correcting hemostatic disorders.The purpose of the study was to study the effect of cisplatin on the blood coagulation system in mice and rats.Results. An experiment using outbred mice showed that the levels of PT-INR and aPTT were decreased and the level of fibrinogen was increased on day 10 after administration of cisplatin in the maximum tolerated dose of 10 mg/kg. A significant decrease in the PT-INR and aPTT levels was observed on day 15 after cisplatin injection only in female mice. The cisplatin injection at a dose of 4 mg/kg resulted in a decrease in the PT-INR, and aPTT levels and an increase in fibrinogen concentration on day 10. In rats, a significant decrease in the PT and aPTT levels was observed in both females and males on day 15 after cisplatin injection.Conclusion. A change in the PT and NIR, aPTT levels towards decrease and fibrinogen concentration towards increase indicates the initiation of thrombus formation.
METHODOLOGICAL APPROACHES TO THE DETERMINATION OF CHEMORESISTANCE OF HUMAN CANCER CELLS TO ANTI-CANCER DRUGS
Authors: Kirsanov K. I. , Kuzin K. A. , Fetisov T. I. , Lesovaya E. A. , Belitskiy G. A. , Yakubovskaya M. G. 
Published: July 2020

The purpose of the study was to analyze the existing methodological approaches to the experimental testing of resistance to chemotherapy and assess the prospects for their further application.Material and Methods. We analyzed publications regarding the experimental testing of tumor resistance to chemotherapy available in the databases, such as SciVerse Scopus (748), PubMed (1727), Web of Science (1025), RSCI (125). To obtain fulltext publications, the electronic resources of Research Gate, RSCI, CyberLenink were used. Forty-two modern publications (2012–19) including 18 articles of the founders of the methods analyzed in the review were cited.Results. The review discusses the characteristics of the main methods for assessing the resistance / sensitivity of tumor cells obtained from biopsy / surgical specimens to various chemotherapy drugs in vitro in monolayer and suspension cultures, in the form of spheroids, histo and organocultures, as well as in vivo xenografts of tumors in immunodeficient mice. During testing, the proliferative and metabolic activities as well as the level of cell death were considered as the main evaluated characteristics of tumor cells. The main indicators were the intensity of DNA synthesis, the level of protein or ATP in the cell, the activity of NADH-dehydrogenases, the level of apoptosis, and the integrity of cell structures. The advantages and disadvantages of the described methods, as well as the prospects for their further application were discussed.Conclusion. Over the past half century of using the experimental testing of tumor cell resistance in order to personalize chemotherapeutic treatment, the evolution of methodological approaches was based on the increase in their safety and sensitivity through the use of fluorescent compounds. The general vector for improving experiments on the personalization of tumor chemotherapy is aimed at approximating the experimental conditions to the processes occurring in the human body. Each of these methods has its own range of predictive power and, if used properly, can provide a useful guide for treatment.
A PARADIGM SHIFT IN THE TREATMENT OF PATIENTS WITH RESECTABLE PANCREATIC CANCER
Authors: Antonova E. Yu. , Bazin I. S. , Garin A. M. , Pokataev I. A. , Sagaidak I. B. , Polyakov A. N. , Chihareva Y. E. , Volkov A. Yu. , Bazina I. V. 
Published: July 2020

Purpose of the study was to provide medical oncologists and surgeons specializing in the treatment of pancreatic cancer patients with the most recent information on the importance and role of chemotherapy in the treatment of patients with resectable and borderline resectable pancreatic cancer.Material and Methods. Pubmed and COSMIC databases were used for literature search. Reports of the executive authorities in the field of Health Care of the Russian Federation, as well as worldwide data regarding morbidity and mortality of patients with pancreatic cancer were analyzed. The data of retrospective and prospective clinical trials were studied.Results. Based on the analysis of the most recent publications, the authors provided data on modern approaches to the treatment of operable pancreatic cancer.Conclusion. The data presented in the article summarize results of recent clinical trials. This will allow oncologists to choose the most correct and personalized tactics for the management of patients with resectable and borderline resectable pancreatic cancer.
MICRORNA IN MONITORING OF THE EVOLUTION OF GLIAL CEREBRAL TUMORS
Authors: Seliverstov R. Yu. , Zaraiskiy M. I. , Tyurin R. V. , Naryshkin A. G. , Valerko V. G. , Semiglazov V. V. , Takahachi Ch. 
Published: July 2020

Glial cerebral tumors (GCT) are primary tumors of the central nervous system that develop from glial tissue. Despite the use of combination treatment, the overall median survival rate in patients with glioblastoma, the most malignant form of HCC, is low. MicroRNA is a large class of endogenous small RNA molecules that inhibit mRNA translation of target genes involved in the evolution of GCT. It was shown that miRNA-21 has antiapoptotic and invasive functions by means of silencing of the PTEN tumor suppressor. MicroRNA-128 can activate a number of genes that are responsible for the mechanisms of suppression of tumor growth. MicroRNA-342, modulating PAK4 gene expression, is involved in the control of tumor cell proliferation, invasion and apoptosis.The aim of the work was to study the feasibility of using the assessment of miRNA-21, -128 and -342 expressions in the blood plasma and saliva of patients to monitor GCT progression or stabilization during combined modality treatment.Material and Methods. The main group consisted of 56 patients with GCTs. (34 men and 22 women), aged 25 to 72 years (average age 48.5 years) GCTs. The control group consisted of 50 people (45 volunteers and 5 neurosurgical patients with extracerebral meningiomas). The study of miRNA-21, -128, and -342 expressions was carried out according to the semiquantitative StemLoopRealTime protocol, using small U6 RNA as a reference gene. Data was processed using the STATISTICA for Windows computer system.Results. In 70 % of patients with disease progression assessed by magnetic resonance imaging, without progression in cerebral and focal neurological signs, the expression level of miRNA21 exceeded the control values both in blood plasma and saliva, and the expression levels of miRNA-128 and -342 were significantly reduced. In patients with GCT stabilization, the expression levels of miRNA-21, -128, and -342 did not go beyond the reference values. The diagnostic significance of miRNA-128, -342 for GCT was 69 %; therefore these miRNAs can be used in a clinical setting. Thus, the increased expression of miRNA-21 and decreased expressions of miRNA-128 and -342 in both blood plasma and saliva indicate cerebral glioma progression.
Removal of methylene blue from aqueous solution using Mg-Fe, Zn-Fe, Mn-Fe layered double hydroxide
Authors: Shi Zhongliang , Wang Yanmei , Sun Shuyu , Zhang Cheng , Wang Haibo 
Published: July 2020

Abstract
Layered double hydroxides (LDH) with highly flexible and adjustable chemical composition and physical properties have attracted tremendous attention in recent years. A series of LDH with different M (Mg, Zn, Mn)-Fe molar ratios were synthesized by the double titration co-precipitation method. The effect of the factors, including M (Mg, Zn, Mn) : Fe molar ratio, pH, and M-Fe LDH dosage, on the ability of the prepared M-Fe LDH to remove cationic methylene blue (MB) dye from aqueous solution were investigated. Results indicated that the removal efficiency of MB (10 mg/L) was the best at the M (Mg, Zn, Mn): Fe molar ratio of 3:1 by using 2.0 g/L of M-Fe LDH at pH 6.0 under 298.15 K. Mg-Fe LDH had the highest removal performance (71.94 mg/g at 298.15 K) for MB compared to those of the Zn-Fe and Mn-Fe LDH. Zn-Fe LDH with the smallest activation energy resulted in the fastest adsorption rate of MB. The pseudo-second-order model and Langmuir adsorption isotherm were also successfully applied to fit the theory of M-Fe LDH for removal of MB.
Use of totally implantable venous port systems in children hematology clinic
Authors: Lyanguzov A. V. , Kalinina S. L. , Sergunina O. Yu. , Ignatyev S. V. , Tselousova O. M. , Vaskina E. A. , Tataurova I. P. 
Published: July 2020

Relevance.Reliable and long-term venous access is one of the most important condition for a successful leukemia therapy in children. Safe and convenient access to a central vein allows to provide chemotherapy, adjuvant treatment, parenteral nutrition and blood transfusion. It decreases the likelihood of phlebitis development and reduction of the peripheral venous network in comparison with peripheral venous access. The use of totally implantable venous port systems reduces risks of severe complications associated with re-catheterization of the central vein thus it improves patient’s quality of life.The purpose of the studyis a retrospective assessment of the experience of use and analysis of the complications of totally implantable venous port systems in children with diseases of the blood system.Materials and methods.The data of 61 patients of the pediatric hematology clinic with venous port systems have been analyzed.Results.Perioperative complications developed in 3 (4.9 %) patients Median time of using of port systems was 679 catheter-days. Delayed complications requiring removal of the device developed in 8 (13.1 %) patients. Infectious complications were the reason for device removal in 3 (2.9 %) patients, mechanical complications in 5 (8.2 %) patients. No thrombotic complications were found.Conclusions.The use of venous port systems in children with hematologic diseases for a long period of time is an effective and safe way for central venous access providing.
Features of the diagnosis of Gaucher disease in children in the Russian Federation
Authors: Movsisyan G. B. , Surkov A. N. , Namazova-Baranova L. S. , Savostyanov K. V. 
Published: July 2020

Relevance. Diagnostic algorithms are an effective tool for the early detection and proper monitoring of patients with a rare pathology.The purpose of the study was to study the epidemiological, medical history, clinical and laboratory features of Gaucher disease (GD) in children in the Russian Federation (RF) to improve the algorithm for its diagnosis in a pediatric cohort of patients.Materials and methods. A retrospective study of data on children with GD included in the pediatric registry of National Health Medical Research Center for Children of the Ministry of Health of Russia was conducted. The data recording period is from 2006 to 2016.Results. The database contains 115 children with GD. The prevalence of the disease was 0.32 per 100 thousand children, with predominance in the Ural and North Caucasian federal districts. Only in 25 % of patients the diagnosis is confirmed within 6 months of the initial treatment. The family nature of the symptoms is established in 22 % of cases. Clinical polymorphism of GD leads to an erroneous interpretation of the diagnosis at primary reversibility in 85 % of cases; unjustified diagnostic and therapeutic measures, including surgical ones, in 70 % and 50 % of cases, respectively, thus leading to a delay in establishing the correct diagnosis up to 3.5 years and prescribing adequate treatment up to 4 years from the date of the examination. Key parameters for diagnosing GD include: damage to the parenchymal organs in the form of splenomegaly in 100 % and hepatomegaly in 94.8 % of patients; a change in hematological parameters in the form of anemia in 86.1 % and thrombocytopenia in 91.3 %; a change in biomarkers in the form of an increase in chitotriosidase activities in 94.0 % and aspartate aminotransferase in 51.0 %; ferritin concentration in 70.6 %, against a background of a decrease in iron content in 60.5 % and lipid metabolism (cholesterol in 54.0 % and high density lipoproteids in 85.0 %); elongation in the coagulogram of activated partial thromboplastin time in 66.2 % and prothrombotic time in 51.6 %; pathology of the skeletal system in the form of chronic bone pain and bone crises in 43 % and 18 % of patients, respectively; limb deformity of the type of “Erlenmeyer flasks” on the radiograph in 55.6 %; involvement of the central nervous system in patients with type II and type III hypertension in the form of oculomotor apraxia in 100 % of cases. An improved algorithm for diagnosing GD in children is proposed.Conclusion. Optimization of the algorithm for diagnosing GD in pediatrics will improve the provision of medical care to children with this orphan pathology in the RF.
Understanding the Pathogenesis Involved in Parkinson’s Disease and Potential Therapeutic Treatment Strategies
Authors: Dhanawat Meenakshi , Mehta Dinesh K. , Gupta Sumeet , Das Rina 
Published: July 2020

:
A vast advancement has been made in the treatment related to central nervous system
disorders especially Parkinson’s disease. The development in therapeutics and a better understanding
of the targets results in upsurge of many promising therapies for Parkinson’s disease. Parkinson’s
disease is defined by neuronal degeneration and neuroinflammation and it is reported that
the presence of the neurofibrillary aggregates such as Lewy bodies is considered as the marker.
Along with this, it is also characterized by the presence of motor and non-motor symptoms, as
seen in Parkinsonian patients. A lot of treatment options mainly focus on prophylactic measures or
the symptomatic treatment of Parkinson’s disease.

:
Neuroinflammation and neurodegeneration are the point of interest which can be exploited as a
new target to emphasis on Parkinson’s disease.

:
A thorough study of these targets helps in modifications of those molecules which are particularly
involved in causing the neuronal degeneration and neuroinflammation in Parkinson’s disease.

:
A lot of drug regimens are available for the treatment of Parkinson’s disease, although levodopa
remains the choice of drug for controlling the symptoms, yet is accompanied with significant
snags. It is always suggested to use other drug therapies concomitantly with levodopa.

:
A number of significant causes and therapeutic targets for Parkinson’s disease have been identified
in the last decade, here an attempt was made to highlight the most significant of them. It was
also found that the treatment regimen and involvement of therapies are totally dependent on individuals
and can be tailored to the needs of each individual patient.
A brief description of the foam concrete: its properties, advantages and disadvantages: review
Authors: Hamada Ruqaya F. , Hameed Awham M. 
Published: July 2020

:
The foam concrete has many advantages when compared to conventional concrete such as advanced strength to
weight ratio as well as the material for energy-saving construction. This concrete has broadly been utilized in the
constructing manufacturing. The current work presents an appraisal of foamed concrete ingredients, fabricating methods,
as well as the foamed concrete features. Furthermore, this literature appraisal aims for providing a complete vision about
the tests, including compressive strength, density, porosity, splitting tensile strength and water absorption of foamed
concrete. Also, this paper focuses to study the development and applications of the foam concrete. The advantages and
disadvantages of this type of concrete were presented in details through this article.
Sustainability Failure in the Antimicrobial Stewardship Program in a Secondary Care Hospital from Cuba: A Historical Review of 30 Years and 3 Shots
Authors: Garcell Humberto G. , Socias Juan J.P. , Gómez Gilberto P. 
Published: July 2020

Background:
During the last 30 years, an Antimicrobial Stewardship Program (ASP)
was implemented in a facility with periods of weakness. We aim to describe the history of sustainability
failure in the local ASP.

Methods:
A historical review was conducted using original data from the facility library and papers
published. An analysis of factors related to the failure was conducted based on the Doyle approach.

Results:
The first ASP was implemented from 1989 to 1996 based on the international experiences
and contributed to the improvement in the quality of prescription, reduction of 52% in cost and in
the incidence of nosocomial infection. The second program restarted in 2008 and declined in 2015,
while, the third program was guided by the Pan-American Health Organization from 2019. This
program, in progress, is more comprehensive than previous ones and introduced as a novel measure
the monitoring of antibiotic prophylaxis in surgery. The factors related to the sustainability
were considered including the availability of antimicrobials, the leader´s support, safety culture,
and infrastructure.

Conclusions:
The history behind thirty years of experiences in antimicrobial stewardship programs
has allowed us to identify the gaps that require proactive strategies and actions to achieve sustainability
and continuous quality improvement.