bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endless Forms Most Beautiful: A Garden Shows That Cancer Is a Part of Life
Authors: Winfrey Pamela , Robertson Caspian , Maley Carlo , Aktipis Athena 
Published: March 2020

Abstract
Endless Forms Most Beautiful is a crested cactus garden that embodies both an aesthetic and a medically transformative approach to cancer. The cacti in this garden have mutations in their meristem cells causing uncontrolled growths—which are, by some definitions, cancer. The garden was installed near the new Biodesign Institute C building on the Arizona State University campus in Tempe. Crested cacti and other fasciated plants are examples of organisms that live with cancer but do not die from it. These plants help to widen the framework for thinking about what cancer is and how to live with it and, ultimately, inspired a new center, the Arizona Cancer Evolution (ACE) Center, which investigates cancer across forms of life.
A Linear Inverse Model of Tropical and South Pacific Seasonal Predictability
Authors: Lou Jiale , O’Kane Terence J. , Holbrook Neil J. 
Published: March 2020

AbstractA multivariate linear inverse model (LIM) is developed to demonstrate the mechanisms and seasonal predictability of the dominant modes of variability from the tropical and South Pacific Oceans. We construct a LIM whose covariance matrix is a combination of principal components derived from tropical and extratropical sea surface temperature, and South Pacific Ocean vertically averaged temperature anomalies. Eigen-decomposition of the linear deterministic system yields stationary and/or propagating eigenmodes, of which the least damped modes resemble El Niño–Southern Oscillation (ENSO) and the South Pacific decadal oscillation (SPDO). We show that although the oscillatory periods of ENSO and SPDO are distinct, they have very close damping time scales, indicating that the predictive skill of the surface ENSO and SPDO is comparable. The most damped noise modes occur in the midlatitude South Pacific Ocean, reflecting atmospheric eastward-propagating Rossby wave train variability. We argue that these ocean wave trains occur due to the high-frequency atmospheric variability of the Pacific–South American pattern imprinting onto the surface ocean. The ENSO spring predictability barrier is apparent in LIM predictions initialized in March–May (MAM) but displays a significant correlation skill of up to ~3 months. For the SPDO, the predictability barrier tends to appear in June–September (JAS), indicating remote but delayed influences from the tropics. We demonstrate that subsurface processes in the South Pacific Ocean are the main source of decadal variability and further that by characterizing the upper ocean temperature contribution in the LIM, the seasonal predictability of both ENSO and the SPDO variability is increased.
Improving Air Quality Predictions over the United States with an Analog Ensemble
Authors: Delle Monache Luca , Alessandrini Stefano , Djalalova Irina , Wilczak James , Knievel Jason C. , Kumar R. 
Published: March 2020

AbstractAir quality forecasts produced by the National Air Quality Forecasting Capability (NAQFC) help air quality forecasters across the United States in making informed decisions to protect public health from acute air pollution episodes. However, errors in air quality forecasts limit their value in the decision-making process. This study aims to enhance the accuracy of NAQFC air quality forecasts and reliably quantify their uncertainties using a statistical–dynamical method called the analog ensemble (AnEn), which has previously been found to efficiently generate probabilistic forecasts for other applications. AnEn estimates of the probability of the true state of a predictand are based on a current deterministic numerical prediction and an archive of prior analogous predictions paired with prior observations. The method avoids the complexity and real-time computational expense of model-based ensembles and is proposed here for the first time for air quality forecasting. AnEn is applied with forecasts from the Community Multiscale Air Quality (CMAQ) model. Relative to CMAQ raw forecasts, deterministic forecasts of surface ozone (O3) and particulate matter of aerodynamic diameter smaller than 2.5 μm (PM2.5) based on AnEn’s mean have lower systemic and random errors and are overall better correlated with observations; for example, when computed across all sites and lead times, AnEn’s root-mean-square error is lower than CMAQ’s by roughly 35% and 30% for O3 and PM2.5, respectively, and AnEn improves the correlation by 50% for O3 and PM2.5. Probabilistic forecasts from AnEn are statistically consistent, reliable, and sharp, and they quantify the uncertainty of the underlying prediction.
Effect of Gender, Age, and Profound Disease on Upper Airway Stimulation Outcomes
Authors: Patel Jena , Daniels Kelly , Bogdan Lauren , Huntley Colin , Boon Maurits 
Published: March 2020

Objective: To evaluate treatment outcomes of upper airway stimulation (UAS) in obstructive sleep apnea (OSA) patients based on patient age, gender, and preoperative disease severity. Methods: Retrospective chart review of patients undergoing UAS from 2014 to 2018 at a tertiary care center. Data collected included demographic information, implantation records, and pre- and postoperative polysomnography (PSG) results. Profound OSA was defined as AHI >65 and age ≥65 was considered advanced age. The primary outcome measured was initial treatment response, defined as a post-operative AHI <20 with a >50% reduction from baseline. Results: 145 patients underwent UAS at our institution including 98 males and 47 females with a mean age of 61.7 ± 11.5 years, mean BMI of 29.1 ± 3.9 kg/m2, and mean preoperative AHI of 34.1 ± 18.2 events/hour. After surgery, patients had a significantly lower mean AHI of 8.6 ± 15.0 events/hour (<0.001). Older patients had a lower initial treatment response rate (78%) when compared to their younger counterparts (94%) ( P = 0.005). Male gender and profound disease status did not significantly impact treatment response rates; young age was the only variable found to predict early treatment response on multivariate analysis ( P = 0.003). Conclusion: Although the overall OSA population showed significant postoperative AHI reduction with UAS, patients age ≥65 years were less likely to have an initial response to treatment, when compared to their younger counterparts. A larger proportion of elderly patients and patients with profound OSA had residual moderate disease (AHI > 15) after UAS. Level of Evidence: 4
Effects of high-intensity interval training in a three-week cardiovascular rehabilitation: a randomized controlled trial
Authors: Wehmeier Udo F , Schweitzer Alexander , Jansen Armin , Probst Herbert , Grüter Stephan , Hähnchen Silke , Hilberg Thomas 
Published: March 2020

Objective: The aim of this study was to assess the benefit of using high-intensity interval training for cardiovascular patients undergoing outpatient rehabilitation in a standard short-term (three-week) program in Germany. Design: This is a randomized controlled trial (RCT). Setting: This study was conducted at Cardiowell (Wuppertal, Germany), an outpatient rehabilitation center. Intervention: Patients underwent the typical three-week German outpatient rehabilitation program using either moderate continuous training (i.e. the standard training program) or high-intensity interval training. Main measures: A total of 50 patients of an outpatient rehabilitation center were randomized into two groups. The control group underwent the standard rehabilitation protocol that applied moderate continuous training, and the intervention group trained according to a high-intensity interval protocol. Patients trained on a bicycle ergometer. Peak power output, oxygen uptake parameters, heart frequencies, and blood pressure were compared at the beginning and at the end of the rehabilitation program. Results: After three weeks, the intervention group had improved to a significantly greater extent in maximal performance parameters than the control group: the peak power output (20.9 (±14.1) W; control 8.8 (±10.4) W), maximum oxygen uptake (0.33 (±0.33) L/min; control 0.05 (±0.29) L/min)), relative maximum oxygen uptake (3.4 (±4.2) mL/kg/min; control 0.9 (±3.1) mL/kg/min), and O2 pulse (1.8 (±2.2) mL/heart beat; control 0.35 (±1.7) mL/heart beat). Conclusion: The implementation of high-intensity interval training during a typical three-week German cardiac rehabilitation has the power to increase the outcome for the patients.
Delayed (14-30 Days) Percutaneous Repair of Achilles Tendon Ruptures Offers Equally Good Results As Compared With Acute Repair
Authors: Maffulli Nicola , D’Addona Alessio , Maffulli Gayle D. , Gougoulias Nikolaos , Oliva Francesco 
Published: March 2020

Background:Minimally invasive repair of acute Achilles tendon ruptures has been performed for several years, resulting in reduced morbidity as compared with open repair.Hypothesis:A minimally invasive technique can be used to manage Achilles tendon ruptures in patients presenting between 14 and 30 days from injury.Study Design:Cohort study; Level of evidence, 3.Methods:We prospectively recruited 21 consecutive patients who presented between 14 and 30 days after the index injury, and we compared them with 21 patients who were matched according to sex, age (±2 years), and level of activity, who presented within 14 days of the index injury. All patients underwent the same minimally invasive procedure under local anesthesia: a core suture repair consisting of a modified Bunnell suture in the proximal stump and a modified Kessler suture in the distal stump.Results:At 12 months after minimally invasive repair, patients with delayed treatment had a median Achilles tendon rupture score of 91 (SD, 2.4; range, 87-96) as compared with 91 (SD, 2.2; range, 86-96) in patients treated acutely, who presented at a median 2.4 days (range 1-6 days) from the injury. There were no significant differences between groups in terms of mean (SD) Achilles tendon resting angle: delayed repair group, −3.9° (2.0); acute repair group, −3.7° (1.9) ( P = .69). No patient in either group developed a wound infection. One patient in the acute group experienced an iatrogenic sural nerve injury.Conclusion:Patients with Achilles tendon rupture treated by percutaneous repair 14 to 30 days after injury achieved similar results at 1 year as patient treated <14 after injury.
Livelihood Enhancement Through Community-owned Agro-service Centres: A Case Study of MAVIM
Authors: Bharti Nisha 
Published: March 2020

Agriculture is the backbone of Indian economy with more than 50 per cent of population been dependent of agriculture for their livelihood. However, low profitability from agriculture, high input cost and seasonality of agriculture produce, fails to make it a sustainable source of livelihood for Indian farmers. The transaction cost theory believes that collective actions can help decrease cost and increase profitability in the sector. Mahila Arthik Vikas Mahamandal (MAVIM) took an initiative to open community managed agro service centers with the objective of providing quality input at a reasonable price. A qualitative study in two districts i.e. Thane and Yavatmal was conducted. Both primary as well as secondary data was collected for this study. Direct contacts and discussions were held with staff of MAVIM district office, community-managed resource center (CMRCs), agro service centers as well as the beneficiaries. The study found that the agro-service centers promoted by MAVIM are doing well and being a form of collective, have helped farmer’s in reducing the cost of operation and increasing their bargaining power in the market. The study concludes that with small changes in the design and structure of the intervention, the organization can help them in achieving their objectives.
Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Authors: Kerliu Lloreta , Myruski Samantha , Bhatti Afeefa , Soni Priyal , Petrosius Paulius , Pervanas Helen C. , Horton Evan R. 
Published: March 2020

Objective: To review the efficacy and safety of niraparib for the treatment of recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer (OC, FTC, and PPC). Data Sources: A literature search via MEDLINE through PubMed from August 2013 to January 2020 was performed using the key terms niraparib, PARP inhibitors, ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. Study Selection and Data Extraction: Completed and ongoing trials were identified through a review of the website trial registry https://www.clinicaltrials.gov . Data Synthesis: In a phase III, double-blind clinical trial, progression-free survival improved in patients treated with niraparib compared with placebo as maintenance treatment for patients with platinum-sensitive, recurrent OC: 21 versus 5.5 months in the germline breast cancer susceptibility gene ( gBRCA) cohort (hazard ratio [HR] = 0.27; 95% CI = 0.17 to 0.41; P < 0.001) and 9.3 versus 3.9 months in the overall nongermline breast cancer susceptibility gene (non- gBRCA) cohort (HR = 0.45; 95% CI = 0.34 to 0.61; P < 0.001). Adverse events included thrombocytopenia and anemia. Relevance to Patient Care and Clinical Practice: Poly (ADP-ribose) polymerase (PARP) inhibitors have gained a place in the therapeutic management of OC, FTC, and PPC because of their ability to suppress growth of homologous recombination deficiency–positive tumors, including those with BRCA1/2 mutations. Niraparib inhibits the DNA repair mechanism vital to the survival of cancer cells, poly-ADP ribose polymerase. Conclusions: PARP inhibitors can be used as a single agent for maintenance therapy for platinum-sensitive recurrent disease in patients with partial or complete response following 2 or more rounds of platinum-based therapy.
The Role of Old Photos in Reminiscence Therapy in Elderly Women With Depressive Symptoms: A Functional Magnetic Resonance Imaging Study
Authors: Wu Dongmei , Chen Taolin , Huang Xiaoqi , Chen Lizhou , Yue Yuchuan , Yang Hao , Hu Xiuying , Gong Qiyong 
Published: March 2020

Background:Although evidence shows that reminiscence therapy relieves depression in the elderly, few studies have explored its mechanisms and it is unclear whether old public photos rather than personal photos are effective prompts.Objectives:The aims of this functional magnetic resonance imaging (fMRI) study with an event-related design were to explore whether old public photos can evoke autobiographical memories and compare brain-activation responses to photos between elderly women with depressive symptoms (DS) and normal controls (NC).Methods:Elderly women with DS ( n = 16) and NC ( n = 18) were recruited from urban communities in Southwest China. Participants responded with a key press to indicate which of 40 photos evoked autobiographical memories at first sight during 3.0 T scanning. Afterward, they rated photos on a 9-point Likert-type scale on the degrees of recall (DOR), arousal, and pleasure elicited and the degree to which photos felt old.Results:Mean DOR scores were 8.47 ± 0.77 and 1.37 ± 1.09 for high- and low-DOR photos, respectively. Response time was longer in DS compared to NC participants. Brain areas activated by exposure to high-DOR photos differed between groups, with reminiscence leading to decreased activation of the bilateral superior temporal gyrus, left inferior frontal gyrus, right parahippocampal gyrus, left cingulate gyrus, right insular lobe, and bilateral cerebellum anterior lobe in DS compared to NC participants.Conclusion:Old public photos can evoke autobiographical memory. DS are associated with brain dysfunction. Early intervention for DS is recommended in the elderly.
Obesogenic Toxicants in Breast Milk of Lactating Women: Investigation of a Risk Factor for Childhood Obesity
Authors: Gautam Bibha , Rogge Mary M. , Acharya Narayan , Keesari Rohali , Almekdash Mhd Hasan 
Published: March 2020

Background:Persistent organic pollutants (POPs), dispersed in all environmental compartments, are associated with increased adipogenesis and body weight. These lipophilic toxicants bioaccumulate in the human body and get transferred from mothers to their offspring via the placental circulation and breast milk. The current study was designed to compare polychlorinated biphenyl (PCB) and hexachlorobenzene (HCB) concentrations between obese and normal-weight lactating women.Methods:A cross-sectional correlation design was used to compare POP concentrations in breast milk samples of 24 obese and 21 normal-weight adult lactating women at their 2- to 8-week postpartum clinic visit. Concentrations of 12 specific PCB congeners and HCB were analyzed using high-resolution gas chromatography coupled with mass spectroscopy.Results:Of 12 targeted PCB congeners, 6 were detected in the breast milk samples of obese women compared to 3 in normal-weight lactating women. PCB presence was not significantly different between the obese and normal-weight groups. HCB was not detected in any of the breast milk samples for either group.Conclusions:This exploratory study revealed no statistically significant difference in the presence of PCBs in breast milk of obese mothers compared to that of normal-weight women. Therefore, fear of increased risk of transmission of these toxicants may not be a good reason to avoid breastfeeding. Results point to the need for a large-scale multicenter study that examines the effect of PCBs on breastfeeding, considering possible geographic variations of the examined phenomenon.
Why do subchondral cysts occur at the medial aspect of the femoral head in hip dysplasia?
Authors: Chang Jae Suk , Song Joo Ho , Kim Ji Wan , Shin Hun-Kyu , Park Hee-Jin , Cho Yongun , Lee Ingyu , Park Jai Hyung 
Published: March 2020

Introduction: Osteoarthritis in dysplastic hips should develop from the lateral side of the acetabulum and the femoral head just below. However, the existence of subchondral cysts located more on the medial side contradicts the weight-loading theory. The aim of this study was to confirm the presence of medial cysts at the femoral head and to investigate the relationship between medial cysts and injuries of the ligamentum teres in hip dysplasia. Methods: A retrospective analysis was conducted on 257 cases of hip dysplasia. All patients had x-rays and 3-dimensional computed tomographies (3D CT) preoperatively and 123 patients had magnetic resonance arthrographies. A comparison was performed between cases with and without medial cysts according to the severity of damage to the ligamentum teres, the presence of bony spurs around the fovea capitis, and the Tönnis grade. Results: Medial subchondral cysts around the fovea capitis were found in 100 cases. Mild osteoarthritis (Tönnis grade 0 or 1) was present in 89% of cases in the medial cyst group. A significant difference between the groups was observed in the incidence of bony spurs around the fovea capitis ( p < 0.05) and injuries of the ligamentum teres ( p < 0.05). Conclusions: The formation of subchondral cysts at the medial femoral head in hip dysplasia may be related to damage in the ligamentum teres. Considering that subchondral cysts develop in early osteoarthritis, the progression of arthritis in hip dysplasia appears to correlate with damage to the ligamentum teres, as well as compressive pressure on the joint.
Acceptability of the FreeStyle Libre Flash Glucose Monitoring System: The Experience of Young Patients With Type 1 Diabetes
Authors: Al Hayek Ayman A , Robert Asirvatham A , Al Dawish Mohamed A 
Published: March 2020

Background: In the current era of modern technology, the development of smart devices such as the flash glucose monitoring (FGM) systems helps patients with diabetes to effortlessly monitor their glucose levels more frequently. In this study, we determine the user acceptability of FGM among young patients with type 1 diabetes (T1D). Methods: A cross-sectional study was performed among 67 young patients with T1D in the age group of 13 to 19 years and who were managed on the FGM method for self-testing the glucose levels for a minimum of 6 months. The participants acceptability measures that were collected with a standard questionnaire and where they rated their experience with the system on a scale of 1 (strongly agree/painless) to 5 (strongly disagree/severe pain). In addition to the demographic and clinical parameters, a closed/structured questionnaire was administered, in order to record the prior and present skin issues, over a 6-month period. Results: From the patient statements regarding sensor application, 95.5% of the study population strongly agreed that the sensor application caused less pain than the routine finger-stick. Similarly, 85% of the users strongly agreed that using the sensor was comfortable, while 94% strongly agreed that they found the small size of the FGM made it easy to wear, 47.8% strongly agreed that wearing the sensor did not attract attention, 70.1% reported no discomfort under the skin, 80.6% stated that the sensor could be scanned without anyone noticing it, 89.6% felt that the sensor did not affect their daily activities, 91% strongly agreed that the sensor was very compatible with their lifestyle, 79.1% reported ease with taking a glucose reading with the scan, 89.6% reported that taking glucose readings with this system would not disrupt their daily activities, and 76.1% participants were excited to share with other individuals their experiences with this system. A comparison of the self-monitoring of blood glucose and freestyle techniques demonstrated that 83.6% participants strongly agreed that it was less painful to get glucose readings from the freestyle sensor, and that it was a more discreet (83.6%), more comfortable (85.1%), easier (95.5%), faster (82.1%), simpler (79.1%), more private (88.1%), and less stressful (77.6%) method, with minimal hassle (74.6%). It is notable here that 86.6% of the participants reported absolutely no pain when the freestyle sensor was applied; also, the majority of the participants (91%) reported no pain symptoms when scanning the sensor. Conclusion: The findings of this study clearly showed that the study population had a high level of acceptability of the FGM.