bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthodoxie als vernachlässigtes Thema und als Zukunftsherausforderung der evangelischen Religionspädagogik in Deutschland
Authors: Schweitzer Friedrich , Simojoki Henrik 
Published: November 2019

Zusammenfassung
Der Beitrag spricht sich in kritisch-konstruktiver Absicht für eine stärkere Integration der orthodoxen Perspektive im religionspädagogischen Wissenschaftsdiskurs aus. Die Argumentation verläuft in drei Schritten: Zunächst wird die breitflächige Ausblendung des orthodoxen Christentums in der evangelischen Religionspädagogik in Deutschland ausgewiesen und problematisiert. Danach richtet sich der Blick auf religionspädagogische Initiativen der Vergangenheit und Gegenwart, die auf eine ökumenische Blickwinkelerweiterung und kooperative Öffnung hin zur Orthodoxie zielen. Abschließend werden religionsdidaktische Klärungsanliegen und religionspädagogische Kooperationsperspektiven für den zu intensivierenden Dialog mit der orthodoxen Religionspädagogik markiert.
El malecu: Una cultura en peligro de extinción
Authors: Espinoza Romero Elvia , Mejía Marín Noemy , Ovares Barquero Sandra 
Published: November 2019

Recibido 05 de mayo de 2010 • Aceptado 31 de agosto de 2010 • Corregido 28 de julio de 2011

El presente artículo versa sobre una de las lenguas indígenas de Costa Rica, el malecu. Esta lengua es una de las que aún se mantienen vivas en el país; no obstante, la comunidad lingüística que la practica, compuesta por menos de 400 personas, tiende a reducirse aceleradamente. Existe un alto riesgo de que en el futuro próximo dicha lengua llegue a desaparecer. El artículo surge como producto de un proyecto de investigación que se plantea la construcción e implementación de estrategias de aprendizaje, que incorporen las costumbres, tradiciones y lengua autóctona de los indígenas malecu; todo esto en el ámbito escolar, para fortalecer la identidad y la cultura de esta población indígena costarricense.
Content and composition of essential oil in lemon balm (Lippia alba (Mill) N.E.Br.) grown with ammonium and nitrate in light environments
Authors: Lima Janderson Do Carmo , Santos Anacleto Ranulfo Dos , Soua Aline Dos Anjos , Santos Marcelo Batista Dos , Alves Pericles Barreto 
Published: November 2019

Medicinal plants have great potential for the production of phytocompounds, which are used for various purposes, mainly in drugs and cosmetics. The aim of this study was to evaluate the essential oil from Lippia alba cultivated with ammonium (NH4+) and nitrate (NO3-) under light environments. The plants were subjected to five ratios of NH4+: NO3- with nutritious solutions and four light environments (red, aluminet and black mesh, and full sun). The experiment design was entirely randomized with a 5 × 4 interaction and five repetitions per treatment, totaling 100 experiment units. The seedlings were transplanted to 6 dm3 plastic pots containing a mixture of washed sand + vermiculite at a ratio of 2:1. At 120 days after application of the treatments, the following parameters were evaluated: yield, content and composition of essential oil. The extraction was performed with the hydrodistillation method using drag of steam for a period of 2 hours. Nine compounds were found in the essential oil, of which neral and geranial represented 90% of the blend. Carvone was only found in the treatment with plants grown under the red mesh and with the 50:50 ratio of ammonium and nitrate.
Efectividad y seguridad del uso de micronutrientes en polvo para tratamiento de niños con anemia: revisión sistemática
Authors: Libreros-Arana Luz Adriana , García-Perdomo Herney Andrés , Valencia Caicedo Alfonso María 
Published: November 2019

Objetivo: Estimar la efectividad del uso de micronutrientes en polvo, comparado con otras intervenciones para tratamiento de niños con anemia. Metodología: Se realizó revisión sistemática, en las siguientes bases de datos: Medline, EMBASE, CENTRAL, LILACS, Psycinfo, Clinicaltrials.gov, Google scholar, open gray y resúmenes de congresos. No restricción de idioma, se incluyeron ensayos clínicos controlados, hasta enero de 2017. Resultados: Se identificaron 14.735 artículos; 3 estudios cumplieron con los criterios de inclusión: Kounnavong, 2011, Lemaire, 2011 y Hirve, 2007. Kounnavong concluyó que la suplementación con MMP tuvo efectos positivos en la reducción de la prevalencia de la anemia y en el mejoramiento de la concentración de hemoglobina; Hirve evidenció un aumento significativo de la Hemoglobina a las 3 y a las 8 semanas en todos los grupos sin diferencias significativas entre ellos. En el estudio de Lemaire, la hemoglobina fue mayor para los sujetos asignados al azar en el grupo que recibe MNP a 2 meses. Conclusiones: No es posible estimar la efectividad del uso de micronutrientes en polvo, comparado con otras intervenciones para tratamiento de niños con anemia, debido a la insuficiencia y heterogeneidad clínica de los estudios incluidos.
Sustained Remission from Drug Addiction among the Attendees of the Meetings of Anonymous Addicts and Rehabilitation Centers in Mashhad, Iran, During 2017
Authors: Aramideh Zahra , Sahbaeiroy Faezeh 
Published: November 2019

Background: Addiction is one of the most complex diseases of the century that for it's treatment various methods have been proposed. In this regard, one of the non-pharmacological methods with a profound effect on drug withdrawal involves the participation of addicted individuals in a 12-step anonymous addiction recovery program. The purpose of this study was to compare the sustained remission from drug addiction among individuals taking part in an anonymous recovery program and those attending a rehabilitation center for drug withdrawal.
Methods: This descriptive study was conducted on 300 participants (150 individuals of the anonymous recovery program and 150 patients of the rehabilitation center) in Mashhad, Iran, using a random sampling technique. Data collection tool was a researcher-made questionnaire consisting of two parts, namely demographic information and information related to sustained remission from drug addiction in the attendees of the two groups.
Results: The obtained results indicated that there was a significant difference between the two groups in term of withdrawal from drug abuse (χ2 = 0.08; P < 0.001). Addiction resumption occurred in 40.7, 48.4, and 10.9% of cases in the first, second, and third months, respectively. Regarding addiction relapses, 42% and 70% of patients in the rehabilitation and anonymous groups failed to accomplish the recovery, respectively. Regarding sustained remission from drug addiction among the investigated subjects, 40% of the cases in the anonymous addict group and 51.6% of individuals in the rehabilitation canter could persistently withdraw from drug abuse for more than 6 and 3 months, respectively. Accordingly, there was a significant difference between the two groups in terms of sustained remission from drug addiction (χ2 = 0.08; P < 0.001).
Conclusion: On the basis of the obtained results, it can be concluded that attendance to anonymous addict meetings can be a useful strategy to continue the addiction withdrawal after the detoxification period.
Qualitative Study of Women's Experiences with In Vitro Fertilization in Maybod City
Authors: Afrasiabi Hossein , Zareei Mahmoodabadi Fatemeh , Zareei Mahmoodabadi Hassan 
Published: November 2019

Background: In vitro fertilization (IVF) is one of the most important treatments of infertility for couples. The purpose of this study was in vitro fertilization experiences of women in Maybod city.
Methods: This study is based on the qualitative approach and Grounded theory method. Under-study populations were infertile females of Maybod City. Cases of the study were 14 women which were selected with purposive sampling up to data saturation. Data of this investigation were collected from semi-structure interviews. After data collection, open, axial and selective coding was performed.
Results: After the first step of coding 348 primary codes were collected and they categorized into five main groups including turning to spirituality, keeping the stability life, overcoming on mutual challenges, mental occupation, and common acceptance.
Conclusion: According to the findings of this study, for women with several unsuccessful experiences of IVF, the main problem related to their infertility is unstable family.
DNA damage in buccal cells in oral PMDs and malignant disorders by comet assay
Authors: Rawat Garima , Urs Aadithya B , Chakravarti Anita , Kumar Priya 
Published: November 2019

Aim: DNA damage associated with Oral Squamous Cell Carcinoma (OSCC) and potentially malignant disorders (PMDs) is produced due to carcinogenic agents or increased oxidative stress. Comet assay can assist in early detection and evaluation of the amount of DNA damage; lymphocytesare the most commonly used cells for performing comet assay. Utilisation of buccal epithelial cells in comet assay can be a minimally invasive and rapid method. The present study compared the efficacy of comet assay in assessing DNA damage in buccal cells over peripheral blood leucocytes (PBLs) in oral potentially malignant and malignant disorders. Methods: The study included fifty five patients each of Leukoplakia, Oral Submucous Fibrosis (OSMF) and OSCC along with fifty five healthy individuals as control. Buccal epithelial cells were collected from all the selected subjects. DNA damage was evaluated bymeasuring the mean tail length (µm). Results: A significantly increased mean tail length (µm) and higher DNA damage were found in OSCC (26.1096 + 1.84355) and there was a progressive stepwise increase in mean tail length from control(8.4982 + 0.93307) to PMD [leukoplakia (14.6105 + 0.71857); OSMF (12.5009 + 1.12694)] to OSCC.The mean tail length in different habit groups was greater than controls, though no significant difference was noted between habit groups. The mean tail length of buccal cells was significantly greater than the mean tail length of PBLs in all study groups and controls. Conclusion: Hence, use of comet assay on buccal epithelial cells can prove to be beneficiary for evaluation of DNA damage.
Improving selectivity of DNA-RNA binding zinc finger using directed evolution
Authors: Sulej Agata Agnieszka 
Published: November 2019

Abstract
Objective
Type C2H2 zinc fingers bind a variety of substrates, specific sequences in the double-stranded DNA counting among them. Engineering efforts led to the discovery of a set of general rules that enable obtaining zinc fingers modules that bind to almost any given sequence. The objective of this work was to determine an analogical set of rules for the binding of specific sequences in DNA-RNA hybrids using directed evolution of ZfQQR zinc finger. The target regions for evolution included the amino acid residues that directly interact with the substrate and linkers between the zinc finger modules.
Results
The directed evolution was performed using selection based on biopanning of phage-displayed libraries of randomized regions in the ZfQQR zinc finger. The applied strategy of randomization of the middle module of the zinc finger along with input library bias and materials used for biopanning hindered the selection of the modules with altered specificity. However, the directed evolution of the linker sequence between modules enabled selection of variants with improved selectivity towards DNA-RNA hybrids in the presence of double-stranded DNA in comparison to the original ZfQQR. This confirms the necessity of linker optimization between modules in zinc finger domains.
Urinary proteome of dogs with kidney injury during babesiosis
Authors: Winiarczyk Dagmara , Michalak Katarzyna , Adaszek Łukasz , Winiarczyk Mateusz , Winiarczyk Stanisław 
Published: November 2019

Abstract
Background
Acute kidney injury is the most frequent complication of babesiosis in dogs and may provide a natural model for identifying early and specific markers of kidney injury in this species. There are limited data on urine proteomics in dogs, and none of the effect of babesiosis on the urine proteome. This study aimed to identify urinary proteins of dogs with kidney injury during the natural course of babesiosis caused by Babesia canis, and to compare them with proteins in a control group to reveal any potential biomarkers predicting renal injury before the presence of azotemia.
Urine samples were collected from 10 dogs of various breeds and sex with naturally occurring babesiosis, and 10 healthy dogs. Pooled urine samples from both groups were separated by 2D (two-dimensional) electrophoresis, followed by protein identification using MALDI-TOF (matrix-assisted laser desorption ionization time of flight) mass spectrometry.
Results
In total, 176 proteins were identified in the urine samples from healthy dogs, and 403 proteins were identified in the urine samples from dogs with babesiosis. Of the 176 proteins, 146 were assigned exclusively to healthy dogs, and 373 of the 403 proteins were assigned exclusively to dogs with babesiosis; 30 proteins were common for both groups. Characteristic analysis of 373 proteins found in dogs with babesiosis led to the isolation of 8 proteins associated with 10 metabolic pathways involved in immune and inflammatory responses.
Conclusions
It was hypothesized that epithelial-mesenchymal transition might play an important role in the mechanisms underlying pathological changes in renal tissue during babesiosis, as indicated by a causal relationship network built by combining 5 of the 10 selected metabolic pathways, and 4 of the 8 proteins associated with these pathways; this network included cadherins, gonadotropin releasing hormone receptors, inflammatory responses mediated by chemokine and cytokine signalling pathways, integrins, interleukins, and TGF-β (transforming growth factor β) pathways. Those pathways were linked by interleukin-13, bone morphogenetic protein 7, α2(1) collagen, and tyrosine protein kinase Fer, which are potential biomarkers of damage during babesiosis in dogs, that might indicate early renal injury.

Keywords: Acute kidney injury, Babesiosis, Dog, Proteomics, Urine
Evaluation of the Influenza Sentinel Surveillance System in the Democratic Republic of Congo, 2012-2015
Authors: Babakazo Pelagie Diambalula , Kabamba-Tshilobo Joelle , Wemakoy Emile Okitolonda , Lubula Léopold , Manya Léonie Kitoko , Ilunga Benoit Kebela , Disasuani Wally , Nkwembe Edith , Kavunga-Membo Hugo , Changachanga Jean-Claude , Muhemedi Saleh , Tamfum Jean-Jacques Muyembe , Tempia Stefano 
Published: November 2019

Abstract
Background The World Health Organization recommends periodic evaluations of influenza surveillance systems to identify areas for improvement and provide evidence of data reliability for policymaking. However, data about the performance of established influenza surveillance systems are limited in Africa, including in the Democratic Republic of Congo (DRC). Methods We used the Centers for Disease Control and Prevention guidelines to evaluate the performance of the influenza sentinel surveillance system (ISSS) in DRC during 2012-2015. The performance of the system was evaluated using eight surveillance attributes: (i) data quality and completeness for key variables, (ii) timeliness, (iii) representativeness, (iv) flexibility, (v) simplicity, (vi) acceptability, (vii) stability and (viii) utility. For each attribute, specific indicators were developed and described using quantitative and qualitative methods. Scores for each indicator were as follows: <60% weak performance; 60-79% moderate performance; ≥80% good performance. Results During 2012-2015, we enrolled and tested 4,339 patients with influenza-like illness (ILI) and 2,869 patients with severe acute respiratory illness (SARI) from 11 sentinel sites situated in 5 of 11 provinces. Influenza viruses were detected in 446 (10.3%) samples from patients with ILI and in 151 (5.5%) samples from patients with SARI with higher detection during December-May. Data quality and completeness was >90% for all evaluated indicators. Other strengths of the system were timeliness, simplicity, stability and utility that scored >70% each. Representativeness, flexibility and acceptability had moderate performance. It was reported that the ISSS contributed to: (i) a better understanding of the epidemiology, circulating patterns and proportional contribution of influenza virus among patients with ILI or SARI; (ii) acquisition of new key competences related to influenza surveillance and diagnosis; and (iii) continuous education of surveillance staff and clinicians at sentinel sites about influenza. However, due to limited resources no actions were undertaken to mitigate the impact of seasonal influenza epidemics. Conclusions The system performed overall satisfactorily and provided reliable and timely data about influenza circulation in DRC. The simplicity of the system contributed to its stability. A better use of the available data could be made to inform and promote prevention interventions especially among the most vulnerable groups.
Pathogenic fungi-induced susceptibility is mitigated by mutual Lactobacillus plantarum in the Drosophila melanogaster model
Authors: Su Wanzhen , Liu Jialin , Bai Peng , Ma Baocang , Liu Wei 
Published: November 2019

Abstract
Abstract
Background
Since animals frequently encounter a variety of harmful fungi in nature, their ability to develop sophisticated anti-fungal strategies allows them to flourish across the globe. Extensive studies have highlighted the significant involvement of indigenous microbial communities in human health. However, the daunting diversity of mammalian microbiota and host genetic complexity are major obstacles to our understanding of these intricate links between microbiota components, host immune genotype, and disease phenotype. In this study, we sought to develop a bacterium-fungus-Drosophilamodel to systematically evaluate the anti-fungal effects of commensal bacteria.
Results
We isolated the pathogenic fungal strain, Diaporthe FY, which was detrimental to the survival and development of Drosophila upon infection. Using Drosophilaas a model system, Drosophila-associated Lactobacillus plantarumfunctioned as a probiotic, and protected the flies from mortality induced by Diaporthe FY. Our results show that L. plantarumhindered the growth of Diaporthe FYin vitro, and decreased the mortality rate of Diaporthe FY-infected flies in vivo, consequently mitigating the toxicity of Diaporthe FYto the hosts. Additionally, the presence of L. plantarumoverrode the avoidance of oviposition on Diaporthe FY-associated substrates.
Conclusions
Diaporthe FYwas identified as a potential Drosophilapathogen. Commensal L. plantarummitigated the susceptibility of Drosophilato pathogenic fungi, providing insight into the natural interplay between commensal and pathogenic microbial communities that contribute to animal health and pathogenesis.
Effect of low dose naloxone on the immune system function of a patient undergoing video-assisted thoracoscopic resection of lung cancer with sufentanil controlled analgesia — a randomized controlled trial.
Authors: Yun Lin , Zhuang Miao , Yue Wu , Fangfang Ge , Qingping Wen 
Published: November 2019

Abstract
Background : Perioperative immune function plays an important role in the prognosis of patients. Several studies have indicated that low-dose opioid receptor blockers can improve immune function.
Methods: Sixty-nine patients undergoing video-assisted thoracoscopic resection of the lung cancer were randomly assigned to either the naloxone group (n=35) or the non-naloxone group (n=34) for postoperative analgesia during the first 48 hours after the operation. Both groups received sufentanil and palonosetron via postoperative analgesia pump, while 0.05μg·kg -1 ·h -1 naloxone was added in naloxone group. The primary outcomes were the level of opioid growth factor （OGF） and immune function assessed by natural killer cells and CD4 + /CD8 + T-cell ratio. Second outcomes were assessed by the intensity of postoperative pain, postoperative rescue analgesia dose, postoperative nausea and vomiting (PONV).
Results: The level of OGF in the naloxone group increased significantly at 24 hours ( p ＜0.001) and 48 hours after the operation ( P <0.01). The natural killer cells ( P <0.05) and CD4 + /CD8 + T-cell ratio ( P <0.01) in the naloxone group increased significantly at 48 hours after the operation. The rest VAS scores were better with naloxone at 12 and 24 hours after operation（ P <0.05）, and the coughing VAS scores were better with naloxone at 48 hours after the operation（ P <0.05). The consumption of postoperative rescue analgesics in the naloxone group was lower (0.00（0.00-0.00）vs 25.00（0.00-62.50））， P <0.05). Postoperative nausea scores at 24 hours after operation decreased in naloxone group（0.00 (0.00-0.00) vs 1.00 (0.00-2.00), P < 0.01).
Conclusion: Infusion of 0.05μg·kg -1 ·h -1 naloxone for patients undergoing sufentanil-controlled analgesia for postoperative pain can significantly increase the level of OGF, natural killer cells, and CD4+/CD8+ T-cell ratio compared with non-naloxone group ，and postoperative pain intensity, request for rescue analgesics, and opioid-related side effects can also be reduced.
Trial registration: ChiCTR1900021043 on January 26, 2019.
Keywords: Low-dose naloxone, Opioid growth factor, Immune function, Postoperative pain, nausea, vomiting
Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer’s disease: diagnosis, longitudinal progress and biological basis
Authors: Zhao Kun , Ding Yanhui , Han Ying , Fan Yong , Alexander-Bloch Aaron F. , Han Tong , Jin Dan , Liu Bing , Lu Jie , Song Chengyuan , Wang Pan , Wang Dawei , Wang Qing , Xu Kaibin , Yang Hongwei , Yao Hongxiang , Zheng Yuanjie , Yu Chunshui , Zhou Bo , Zhang Xinqing , Zhou Yuying , Jiang Tianzi , Zhang Xi , Liu Yong 
Published: November 2019

Abstract
Background: Hippocampal morphological change is one of the main hallmarks of Alzheimer's disease (AD). The primary aim of this study is to explore whether radiomics feature is a robust biomarker for AD and further explore the biological basis of those features.Methods: Hippocampal radiomic features were extracted for classification and prediction using a support vector machine (SVM) with 1943 subjects (multi-site).Results: Multivariate classifier-based SVM analysis provided individual-level predictions for distinguishing AD patients (N=261) from normal controls (NCs; N=231) with accuracy=88.21% with inter-site cross-validation. Further analyses of a large, independent ADNI dataset (N=1228) reinforced these findings. In mild cognitive impairment (MCI) groups, a systemic analysis demonstrated that the identified features were significantly associated with clinical features (e.g., apolipoprotein E (APOE) genotype, polygenic risk scores, cerebrospinal fluid (CSF) Aβ, CSF Tau), and longitudinal changes in cognition ability; more importantly, the radiomic features have a consistently altered pattern with changes in the MMSE scores over 5 years of follow-up.Conclusion: These comprehensive results suggest that hippocampal radiomic features can serve as robust biomarkers for clinical applications in AD/MCI.