bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case study on year round fodder production scheme for smallholder dairy producers in Bangladesh
Authors: Sarker NR , Yeasmin F Tabassum D , Habib MA , Amin MR 
Published: December 2020

This study was undertaken to develop a year round fodder production model for small scale dairy farmers. Five pregnant dairy cows of Red Chittagong Cattle (RCC) genotype were selected. For rearing five cows, 66 decimal of land was selected from existing fodder plots under Pachutia Research Farm at Bangladesh Livestock Research Institute (BLRI), Savar, Dhaka. The selected land was divided into two parts (33 decimal in each). One part was brought under perennial (Napier-4 and Splendida) and the 2nd part of land for seasonal (Maize & Matikalai) fodder production. Data on live weight and live weight gain of cows, birth weight of calves, feed intake, milk production, actual biomass yield for both perennial and seasonal fodder, yearly manure production were recorded and calculated. Napier-4 grass, splendida, maize, straw, silage were supplied to the experimental cows according to the seasonal availability in different months. Concentrate mixture were also supplied consisting of wheat bran, kheshari (red gram), soybean meal, maize crushed, til oil cake, DCP and common salt. Economics of the model revealed that considering the sale of milk, calves and manure and cost included only feed and land leased, a farm/family rearing 5 indigenous dairy cows with his/her family labours, he/she could earn around BDT 98 thousand in a year (1$ = 85 BDT) and the benefit cost ratio of the model on total variable cost and total cost were 1.86 and 1.66, respectively. Therefore, it may be recommended that a farmer having 5 adult dairy cows with 66 decimal land under fodder cultivation may earn substantial share of his/her family income as small-scale rural dairying.
Bang. J. Livs. Res. Vol. 26 (1&2), 2019: P. 89-102
The Techno-Economic Benefit of Sorption Enhancement: Evaluation of Sorption-Enhanced Dimethyl Ether Synthesis for CO2 Utilization
Authors: Skorikova Galina , Saric Marija , Sluijter Soraya Nicole , van Kampen Jasper , Sánchez-Martínez Carlos , Boon Jurriaan 
Published: December 2020

Dimethyl ether (DME) is an important platform chemical and fuel that can be synthesized from CO2 and H2 directly. In particular, sorption-enhanced DME synthesis (SEDMES) is a novel process that uses the in situ removal of H2O with an adsorbent to ensure high conversion efficiency in a single unit operation. The in situ removal of steam has been shown to enhance catalyst lifetime and boost process efficiency. In addition, the hydrogen may be supplied through water electrolysis using renewable energy, making it a promising example of the (indirect) power-to-X technology. Recently, major advances have been made in SEDMES, both experimentally and in terms of modeling and cycle design. The current work presents a techno-economic evaluation of SEDMES using H2 produced by a PEM electrolyzer. A conceptual process design has been made for the conversion of CO2 and green H2 to DME, including the purification section to meet ISO fuel standards. By means of a previously developed dynamic cycle model for the SEDMES reactors, a DME yield per pass of 72.4 % and a carbon selectivity of 84.7% were achieved for the studied process design after optimization of the recycle streams. The production costs for DME by the power-to-X technology SEDMES process at 23 kt/year scale are determined at ∼€1.3 per kg. These costs are higher than the current market price but lower than the cost of conventional DME synthesis from CO2. Factors with the highest impact on the business cases are the electricity and CO2 cost price as well as the CAPEX of the electrolyzer, which is considered an important component for technology development. Furthermore, as the H2 cost constitutes the largest part of the DME production cost, SEDMES is demonstrated to be a powerful technology for efficient conversion of green H2 into DME.
Geological Carbon Sequestration by Reactive Infiltration Instability
Authors: Sun Yizhuo , Payton Ryan L. , Hier-Majumder Saswata , Kingdon Andrew 
Published: December 2020

We study carbon capture and sequestration (CCS) over time scales of 2000 years by implementing a numerical model of reactive infiltration instability caused by reactive porous flow. Our model focuses on the mineralization of CO2 dissolved in the pore water—the geological carbon sequestration phase of a CCS operation—starting 10–100 years after the injection of CO2 in the subsurface. We test the influence of three parameters: porosity, mass fraction of the Ca-rich feldspar mineral anorthite in the solid, and the chemical reaction rate, on the mode of fluid flow and efficiency of CaCO3 precipitation during geological carbon sequestration. We demonstrate that the mode of porous flow switches from propagation of a planar front at low porosities to propagation of channels at porosities exceeding 10%. The channels develop earlier for more porous aquifers. Both high anorthite mass fraction in the solid phase and high reaction rates aid greater amounts of carbonate precipitation, with the reaction rate exerting the stronger influence of the two. Our calculations indicate that an aquifer with dimensions 500 m × 2 km × 2 km can sequester over 350 Mt solid CaCO3 after 2000 years. To precipitate 50 Mt CaCO3 after 2000 years in this aquifer, we suggest selecting a target aquifer with more than 10 wt% of reactive minerals. We recommend that the aquifer porosity, abundance of reactive aluminosilicate minerals such as anorthite, and reaction rates are taken into consideration while selecting future CCS sites.
Parkinson’s Disease in Teneurin Transmembrane Protein 4 (TENM4) Mutation Carriers
Authors: Pu Jia-Li , Gao Ting , Si Xiao-Li , Zheng Ran , Jin Chong-Yao , Ruan Yang , Fang Yi , Chen Ying , Song Zhe , Yin Xin-Zhen , Yan Ya-Ping , Tian Jun , Zhang Bao-Rong 
Published: December 2020

IntroductionMutations in the teneurin transmembrane protein 4 (TENM4) gene, known to be involved in neuropsychiatric disorders, have been identified in three pedigree of essential tremor (ET) from Spain. ET has overlapping clinical manifestations and epidemiological symptoms with Parkinson’s disease (PD), suggesting these two disorders may reflect common genetic risk factors. In this study, we investigated clinical and genetic manifestations in four unrelated pedigrees with both ET and PD in which TENM4 variants were identified.MethodsWe subsequently explored whether TENM4 variants contributed to the risk of developing PD. The frequency of TENM4 variants was evaluated from four PD pedigrees and other 407 subjects.ResultsThe results revealed 12 different novel heterozygous variants, all at low frequency. A clear general enrichment of TENM4 variants was detected in early onset PD patients (p &lt; 0.001, OR = 5.264, 95% CI = 1.957–14.158).ConclusionThe results indicate that rare TENM4 variants may be associated with an increased risk of PD.
Brucella-Induced Downregulation of lncRNA Gm28309 Triggers Macrophages Inflammatory Response Through the miR-3068-5p/NF-κB Pathway
Authors: Deng Xingmei , Guo Jia , Sun Zhihua , Liu Laizhen , Zhao Tianyi , Li Jia , Tang Guochao , Zhang Hai , Wang Wenjing , Cao Shuzhu , Zhu Dexin , Tao Tingting , Cao Gang , Baryshnikov P. I. , Chen Chuangfu , Zhao Zongsheng , Chen Lihua , Zhang Hui 
Published: December 2020

ObjectivesThe underlying mechanism of the inflammatory response against Brucellosis caused by Brucella remains poorly understood. This study aimed to determine the role of long non-coding RNAs (lncRNAs) in regulating of inflammatory and anti-Brucella responses.Materials and methodsMicroarray analysis was performed to detect differentially expressed lncRNAs in THP-1 cells infected with an S2308 Brucella strain. The candidate lncRNAs were screened using bioinformatic analysis and siRNAs; bioinformatic prediction and luciferase reporter assay were also conducted, while inflammatory responses was assessed using RT‐qPCR, western blot, immunofluorescence, ELISA, HE, and immunohistochemistry.ResultsThe lncRNA Gm28309 was identified to be involved in regulating inflammation induced by Brucella. Gm28309, localized in the cytoplasm, was down-expressed in RAW264.7 cells infected with S2308. Overexpression of Gm28309 or inhibition of miR-3068-5p repressed p65 phosphorylation and reduced NLRP3 inflammasome and IL-1β and IL-18 secretion. Mechanistically, Gm28309 acted as a ceRNA of miR-3068-5p to activate NF-κB pathway by targeting κB-Ras2, an inhibitor of NF-κB signaling. Moreover, the number of intracellular Brucella was higher when Gm28309 was overexpressed or when miR-3068-5p or p65 was inhibited. However, these effects were reversed by the miR-3068-5p mimic.ConclusionsOur study demonstrates, for the first time, that LncRNAs are involved in regulating immune responses during Brucella infection, and Gm28309, an lncRNA, plays a crucial role in activating NF-κB/NLRP3 inflammasome signaling pathway.
Antibiotic Treatment for Chronic Rhinosinusitis: Prescription Patterns and Associations With Patient Outcome and the Sinus Microbiota
Authors: Lux Christian A. , Wagner Mackenzie Brett , Johnston James , Zoing Melissa , Biswas Kristi , Taylor Michael W. , Douglas Richard G. 
Published: December 2020

BackgroundChronic rhinosinusitis (CRS) is a common and debilitating inflammatory condition of the sinuses, afflicting 5% of the general population. Although antibiotics are frequently prescribed for the medical management of CRS, there is surprisingly little evidence to support their efficacy. In this study, we aimed to establish associations between medication usage, the sinus microbiota and patients’ clinical outcomes.MethodsAntibiotic prescription patterns for the year before sample collection of 156 CRS patients, 45 disease control patients (mostly requiring septoplasty and inferior turbinate reduction) and 35 healthy control subjects were examined and analyzed together with previously published bacterial 16S rRNA gene amplicon data from our group.ResultsThe highest antibiotic usage was observed among the two CRS patient categories. Despite heavy antibiotic usage, CRS patients’ clinical outcomes as indicated by patient questionnaires and radiologic scores were similar to those patients that did not receive any antibiotics. The sinus microbiota was dominated by members of the bacterial genera Corynebacterium and Staphylococcus in all three cohorts. Bacterial community dispersion as measured by principal coordinate analysis was significantly higher in CRS patients compared to healthy control subjects, but not disease control patients. Pairwise comparisons within cohorts revealed differences in the relative 16S rRNA gene sequence abundances of the genera Staphylococcus and Lawsonella between antibiotic users and non-users. However, overall antibiotic effects were minimal and unpredictable.ConclusionThe unpredictable effects of antibiotic treatment on the sinus microbiota found in this study, together with the lack of differences in patients’ symptom scores between cohorts, do not support preoperative antibiotic treatment for CRS patients.
Case Report: Association of a Variant of Unknown Significance in the FIG4 Gene With Frontotemporal Dementia and Slowly Progressing Motoneuron Disease: A Case Report Depicting Common Challenges in Clinical and Genetic Diagnostics of Rare Neuropsychiatric and Neurologic Disorders
Authors: Bergner Caroline Gertrud , Neuhofer Christiane Michaela , Funke Claudia , Biskup Saskia , von Gottberg Philipp , Bartels Claudia , Koch Jan Christoph , Radenbach Katrin 
Published: December 2020

BackgroundModern genetics have in many ways revolutionized clinical routine and have, for instance, shown that formerly distinct disease entities relate to common pathogenic mutations. One such example is the connection between dementia and amyotrophic lateral sclerosis (ALS) in a continuous disease spectrum affirmed by the discovery of shared mutations.Case ReportWe describe a new variant in the FIG4 gene in a patient with slowly progressing frontotemporal dementia (FTD) and probable primary lateral sclerosis (PLS). The patient initially showed depressive symptoms and global cognitive deficits. Severe difficulties with language and hallucinations became clearer as the disease progressed. Nuclear medicine imaging and cerebrospinal fluid (CSF) biomarkers were not specific for defined categories of dementia, but neuropsychological testing and clinical features finally led to an allocation of the syndrome to the non-fluent variant of primary progressive aphasia (nfv PPA). Because of increasing limb weakness and bulbar symptoms, motoneuron disease in the form of PLS was diagnosed, strongly supported by elevated CSF neurofilament and electrophysiologic assessments. The detected variant in the FIG4 gene is described as pathogenic or likely pathogenic in common databases and reported once in the literature. While the phenotype of our patient fits the description of FIG4-associated disease in literature, we consider the present variant as VUS in this case.ConclusionWe describe a variant in the FIG4 gene in a patient with slowly progressing FTD and PLS. Mutations in the FIG4 gene have been associated with ALS and PLS; however, this exact mutation was not reported in ALS or PLS patients before. The case illustrates generic diagnostic challenges in patients presenting with genetic variants that offer an explanation for otherwise uncommon symptom combinations but yet are of unknown significance.
Long-Term Safety of Rapid Daratumumab Infusions in Multiple Myeloma Patients
Authors: Gozzetti Alessandro , Bacchiarri Francesca , Sammartano Vincenzo , Defina Marzia , Sicuranza Anna , Mecacci Bianca , Zappone Elisabetta , Cencini Emanuele , Fabbri Alberto , Raspadori Donatella , Bocchia Monica 
Published: December 2020

Multiple myeloma survival has significantly improved in recent years, due to novel agents that are available for treatment. The anti-CD38 monoclonal antibody Daratumumab is particularly efficient for patients with relapse/refractory disease, and many studies have shown its unprecedented efficacy also as a first treatment. However, to avoid the incidence of infusion reactions, long infusion schedules of 8 h at first dose and 4 h in the following doses are required, which can reduce the compliance of patients and health care professionals. A reduced infusion time of 90 min has been reported previously, but data are missing on the prolonged safety of this over time as well as the efficacy of this approach. In this work, we investigate the safety of 484 rapid Daratumumab infusions given early after the second dose over a 22 months period in 39 myeloma patients.
Association Between Plasma Metabolites and Psychometric Scores Among Children With Developmental Disabilities: Investigating Sex-Differences
Authors: Sotelo-Orozco Jennie , Abbeduto Leonard , Hertz-Picciotto Irva , Slupsky Carolyn M. 
Published: December 2020

Background:Developmental disabilities are defined by delays in learning, language, and behavior, yet growing evidence has revealed disturbances in metabolic systems that may also be present. Little is known about whether these metabolic issues contribute to the symptoms or severity of these disabilities, or whether sex plays a role in these associations, given that boys are disproportionately affected by some developmental disabilities. Here we sought to investigate the correlation between psychometric scores, sex, and the plasma metabolome.Methods:The plasma metabolomes of children with autism spectrum disorder (ASD;n= 167), idiopathic developmental delay (i-DD;n= 51), Down syndrome (DS;n= 31), and typically developing controls (TD;n= 193) were investigated using NMR spectroscopy. Spearman rank correlations and multiple linear regression models (adjusted for child's neurodevelopmental diagnosis, child's sex, child's age, child's race/ethnicity, maternal age at child's birth, and parental homeownership) were used to examine the association between plasma metabolites and sex in relation to psychometric measures of cognitive skills, adaptive behavior, and maladaptive behavior in our study population.Results:Higher levels of metabolites involved in cellular energy and mitochondrial function among children with ASD (fumarate and cis-aconitate), DS (lactate), and TD (pyruvate) are associated with poorer cognitive and adaptive subscales. Similarly, higher o-acetylcarnitine associated with deficits in cognitive subscales among all DS cases and TD boys, and carnitine correlated with increased maladaptive behavior among girls with ASD and girls with DS. Among children with DS, elevated myo-inositol, ornithine, and creatine correlated with poorer scores across several subscales. Even among TD cases, elevated 3-hydroxybutyrate correlated with decreased receptive language. In contrast, higher levels of glutamate were associated with better socialization skills among ASD cases. Even after adjusting for the child's neurodevelopmental diagnosis, sex, and other possible confounders, key metabolites including glycolysis metabolites (lactate and pyruvate), ketone bodies (3-hydroxybutyrate and acetoacetate), TCA cycle metabolites (cis-aconitate and fumarate), as well as ornithine were associated with deficits in multiple domains of cognitive function, adaptive skills, and aberrant behaviors.Conclusions:Our results highlight that some plasma metabolites may relate to specific functional subdomains within cognitive, adaptive, and behavioral development with some variation by diagnosis and sex.
Tüberküloz Peritonit Tanısı ile Takip Edilen Olguların Değerlendirilmesi
Authors: KAVAK Şeyhmus , KAYA Şafak , SÖĞÜTÇÜ Nilgün , ALP Vahhac , YILDIRIM Dinçer 
Published: December 2020

Amaç: Son yıllarda ekstrapulmoner tüberküloz olgularının arttığı gözlenmektedir. Tüberküloz peritonit nadir görülen ekstrapulmoner tüberküloz formudur. Bu çalışmada tüberküloz peritonit olgularını irdeledik.
Yöntem: Bu çalışma, Ocak 2012-Şubat 2020 tarihleri arasında hastanemizde tüberküloz peritonit tanısıyla takip edilen toplam 23 hastanın verisini içeren retrospektif bir çalışmadır. Veriler hasta dosyalarından, hastane veri kayıt sisteminden elde edilmiştir.
Bulgular: Hastaların 8 (%34.8)’i erkek, 15 (%65.2)’i kadın, yaş ortalaması 41,5±22.1 idi. Beş (%21.7) hastada hipertansiyon, 3 (%13)’ünde diyabetes mellitus mevcuttu. Hastaların 20 (%87)’sinde karın ağrısı, 18 (%78.3)’inde ateş, karında şişlik ve asit, 17 (%73.9)’sinde gece terlemesi, 14 (%60.9)’ünde iştahsızlık mevcuttu. Onaltı (%69.5) hastada radyolojik yöntem olarak bilgisayarlı tomografi ve ultrasonografi, 7 (%30.5) hastada sadece bilgisayarlı tomografi kullanıldı. Hastaların 17 (%73.9)’sinde tanı histopatolojik, 3 (%13)’ünde mikrobiyolojik, 3 (%13)’ünde ise hem mikrobiyolojik hem histopatolojik olarak konuldu.
Sonuç: Tüberküloz peritonitte erken tedavi önemli olduğundan en kısa sürede tanıya gidilmelidir. Radyolojik bulgular nonspesifik olmakla beraber tanıda yardımcıdır. Hem düşündürücü bulgular olması hem de asit sıvısı ve periton incelemesi için ultrasonografi ve bilgisayarlı tomografi oldukça yol göstericidir.
Pregnancy-related Anxiety Scale (The PrAS): Validity and Reliability Study of its Turkish Version
Authors: ŞOLT Ayça , KANZA GÜL Derya 
Published: December 2020

Aims: Women may have anxiety during pregnancy. This anxiety may have adverse results both for women and their infants. A scale is needed to determine this anxiety, that occurs during pregnancy, psychometrically. This study aims to conduct the reliability and validity study of the PrAS in Turkish population.
Materia and Method: The study was designed methodologically. The data of the study were collected in the Obstetrics Outpatient clinic of a private hospital located in Istanbul. The participants were composed of 495 pregnant women (primiparous and multiparous).
Results and Discussion: The internal consistency of the Turkish version of the PrAS (Cronbach's alpha = 0.85), the correlation coefficient of the items (0.27 and 0.57) and the confirmatory factor analysis (CFA= 0.35 and 0.98) were found to be high. The PrAS had a high correlation with PRAQ-R2 (multiparous pregnant women r= 0.60, primiparous pregnant women r= 0.65, p= 0.000)
Conclusion: It was demonstrated that the Turkish version of the PrAS was a reliable and valid instrument to assess the anxiety level experienced during pregnancy and this instrument may be easily adapted to other languages.
Harapan Pada Lansia Dengan Diabetes Melitus Tipe 2
Authors: Ifianti Lailatuz Zalia , Widyastuti Rita Hadi 
Published: December 2020

Diabetes melitus adalah gangguan metabolik yang ditandai dengan kenaikan kadar glukosa dalam darah dan dapat menyebabkan berbagai macam komplikasi sehingga mempengaruhi kualitas hidup lansia. Harapan akan membawa kepada keoptimisan dan meningkatkan kualitas hidup lansia dengan penyakit kronis. Sementara penelitian mengenai dampak harapan masih sangat kurang. Penelitian ini bertujuan untuk mendeskripsikan derajat harapan pada lansia dengan diabetes melitus tipe 2.Penelitian ini menggunakan desain penelitian kuantitatif survei, responden terdiri dari 127 lansia yang menderita DM tipe 2 yang diambil dengan teknik total sampling setelah memenuhi kriteria inklusi. Kuesioner HHI (Herth Hope Index) digunakan untuk mengetahui gambaran harapan. Uji validitas dan reliabilitas telah dilakukan dan hasilnya valid serta reliabel. Hasil penelitian ini menunjukkan bahwa karakteristik responden adalah didominasi usia 60-74 tahun, sebagian besar berjenis kelamin wanita, tingkat pendidikan didominasi oleh pendidikan SD-SMP, sebagian besar menikah, Suku Jawa, menderita DM < 5 tahun dan tidak mengalami komplikasi. Derajat harapan menunjukkan bahwa responden mempunyai harapan yang tinggi dengan nilai mean sebesar 37.41. Sebagian besar responden merasa hidupnya memiliki nilai dan berharga.Masyarakat dan petugas kesehatan harus membantu lansia mempertahankan derajat harapan yang sudah tinggi dengan menyediakan dukungan sosial dan membantu lansia mencari jalan keluar ketika menghadapi masalah tentang kesehatan dan yang lainnya. Kata Kunci: diabetes mellitus; harapan; lansiaHOPE IN ELDERLY WITH DIABETES MELITUS TYPE 2Diabetes mellitus is a metabolic disorder that signed with the increase of glucose level in blood and can make various complication which influences the elderly’s quality of life. Hope will bring the optimism and increased the quality of life on elderly with chronic diseases. However, research supporting this effect is lacking. This study was aimed to find out the description of the hope level among elderly with diabetes mellitus type 2. This study was quantitative descriptive with 127 elderly diabetic patients taken by using total sampling technique by fulfilling the inclusion criteria. Herth Hope Index (HHI) questionnaire was used. The validity and reliability was confirmed. The results of this research show that the age of respondent was dominated with 60-74 years old, mostly consist of female. The education level was mostly elementary school, mostly have been married and from Javanese family, suffered from DM for about 5 years and mostly didn’t have complications. For the hope level, the respondent mostly is in high level with mean score is 37.41. The respondent feel that their life is worth and precious. Based on the results of this research, the society and health center member should help the elderly to maintenance their level of hope by give the support system to the elderly and facilitate the elderly to solve their problem about health or another. Keywords: diabetes mellitus; elderly; hope