bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial bee colony method for identifying eavesdropper in terrestrial cellular networks
Authors: Udaya Suriya Rajkumar D. , Gavaskar P. Sunil , Al‐Turjman Fadi , Sathiyaraj R. , Balusamy Balamurugan 
Published: April 2020

AbstractNowadays, with the extensive variety of uses of the terrestrial cellular network, the security requirement for these networks is expanding enormously. Although these networks have faced various attacks, the eavesdropper is the most remarkable one. In this attack, once in a while, the foe node postures itself as a bogus base station (BS) and obtains information from achieving the main BS or changes the obtained information. In this article, a well‐organized swarm intelligence approach is proposed within the context of agent‐based models to recognize eavesdroppers, and artificial bee colony attack detection can distinguish the eavesdropper with regard to the node IDs characterized in the rule_set. The nodes that create a caution on distinguishing an intruder are assembled collectively. To recognize the intruder, a voting method is projected. Artificial bee colony Boolean sign generation is projected, which is distributed to the cautioned nodes in the grouping, the keys for sign the expect list to consent on the intruder. The proposed techniques recognize the aberrant relations without producing false positives and limit the capacity in the nodes of the terrestrial network, in contrast with Intrusion Detection Architecture, for the identification of eavesdroppers.
Findings on the relationship between Internet addiction and psychological symptoms in Brazilian adults
Authors: Andrade André Luiz Monezi , Scatena Adriana , Bedendo André , Enumo Sonia Regina Fiorim , Dellazzana‐Zanon Letícia Lovato , Prebianchi Helena Bazanelli , de Lara Machado Wagner , de Micheli Denise 
Published: April 2020

This study evaluated the prevalence of Internet addiction (IA) and its association with negative psychological symptoms in Brazilian adults. A network analysis was conducted to estimate specific variables and their expected influence on IA. In this cross‐sectional study, 15,476 adults (Mage = 37.5, SD = 9.59) completed an open web‐based survey. Three questionnaires were used: the Internet Addiction Test (IAT), Depression Anxiety and Stress Scale (DASS‐21) and Satisfaction With Life Scale (SWLS). Based on IAT scores, participants were classified as No‐Risk user (NRU), Low‐Risk user (LRU) or High‐Risk user (HRU). We observed that 4.8% of the participants were classified in the HRU group. In addition, their risk for severe symptoms of depression was 10 times higher and, for anxiety, seven times higher than that in the NRU group (p < .001). Time spent using smartphones was also significantly higher in the HRU group (Mhours = 5.1, p < .001). The main factors associated with IA were depression, gender and anxiety, but the variable “having children” was the most influential in the IA network. These findings suggest that psychiatric symptoms are the main factors associated with IA among the adult population.
TNF Receptor-Associated Factor 6 Mediates TNFα-Induced Skeletal Muscle Atrophy in Mice During Aging
Authors: Li Jinbo , Yi Xiangjiao , Yao Zhenqiang , Chakkalakal Joe V , Xing Lianping , Boyce Brendan F 
Published: April 2020

ABSTRACT
During aging, muscle mass decreases, leading to sarcopenia, associated with low-level chronic inflammation (inflammaging), which induces sarcopenia by promoting proteolysis of muscle fibers and inhibiting their regeneration. Patients with a variety of pathologic conditions associated with sarcopenia, including rheumatoid arthritis (RA), have systemically elevated TNFα serum levels, and transgenic mice with TNFα overexpression (TNF-Tg mice, a model of RA) develop sarcopenia between adolescence and adulthood before they age. However, if and how TNFα contributes to the pathogenesis of sarcopenia during the normal aging process and in RA remains largely unknown. We report that TNFα levels are increased in skeletal muscles of aged WT mice, associated with muscle atrophy and decreased numbers of satellite cells and Type IIA myofibers, a phenotype that we also observed in adult TNF-Tg mice. Aged WT mice also have increased numbers of myeloid lineage cells in their skeletal muscles, including macrophages and granulocytes. These cells have increased TNFα expression, which impairs myogenic cell differentiation. Expression levels of TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase, which mediates signaling by some TNF receptor (TNFR) family members, are elevated in skeletal muscles of both aged WT mice and adult TNF-Tg mice. TRAF6 binds to TNFR2 in C2C12 myoblasts and mediates TNFα-induced muscle atrophy through NF-κB-induced transcription of the muscle-specific E3 ligases, Atrogen1 and Murf1, which promote myosin heavy-chain degradation. Haplo-deficiency of TRAF6 prevents muscle atrophy and the decrease in numbers of satellite cells, Type IIA myofibers, and myogenic regeneration in TRAF6+/−;TNF-Tg mice. Our findings suggest that pharmacologic inhibition of TRAF6 signaling in skeletal muscles during aging could treat/prevent age- and RA-related sarcopenia by preventing TNFα-induced proteolysis and inhibition of muscle fiber regeneration. © 2020 American Society for Bone and Mineral Research.
Potential and limits of exploitation of crop wild relatives for pea, lentil, and chickpea improvement
Authors: Coyne Clarice J. , Kumar Shiv , von Wettberg Eric J.B. , Marques Edward , Berger Jens D. , Redden Robert J. , Ellis T.H. Noel , Brus Jan , Zablatzká Lenka , Smýkal Petr 
Published: April 2020

AbstractLegumes represent the second most important family of crop plants after grasses, accounting for approximately 27% of the world's crop production. Past domestication processes resulted in a high degree of relatedness between modern varieties of crops, leading to a narrower genetic base of cultivated germplasm prone to pests and diseases. Crop wild relatives (CWRs) harbor genetic diversity tested by natural selection in a range of environments. To fully understand and exploit local adaptation in CWR, studies in geographical centers of origin combining ecology, physiology, and genetics are needed. With the advent of modern genomics and computation, combined with systematic phenotyping, it is feasible to revisit wild accessions and landraces and prioritize their use for breeding, providing sources of disease resistances; tolerances of drought, heat, frost, and salinity abiotic stresses; nutrient densities across major and minor elements; and food quality traits. Establishment of hybrid populations with CWRs gives breeders a considerable benefit of a prebreeding tool for identifying and harnessing wild alleles and provides extremely valuable long‐term resources. There is a need of further collecting and both ex situ and in situ conservation of CWR diversity of these taxa in the face of habitat loss and degradation and climate change. In this review, we focus on three legume crops domesticated in the Fertile Crescent, pea, chickpea, and lentil, and summarize the current state and potential of their respective CWR taxa for crop improvement.
Cu(II)‐Metallacryptands Self‐Assembled to Vesicular Aggregates Capable of Encapsulating and Transporting an Anticancer Drug Inside Cancer Cells
Authors: Biswas Protap , Sarkar Koushik , Dastidar Parthasarathi 
Published: April 2020

AbstractCrystallographically characterized M2L4 type cationic Cu(II)‐metallacryptands [MC(X)] derived from a series of bis‐pyridyl‐bis‐urea ligands (LX; X = O, S, C) are self‐assembled to single‐layered vesicular aggregates in DMSO, DMSO/water, and DMSO/DMEM (biological media). One such vesicle is MC(O)‐vesicle that is demonstrated to be able to load and release (pH responsive) an anticancer drug, namely doxorubicin hydrochloride (DOX). DOX‐loaded MC(O)‐vesicle is also successfully transported within MDA‐MB‐231 cells—a highly aggressive human breast cancer cell line. Such self‐assembling behavior to form vesicular aggregates by metallacryptands (MCs) is hitherto unknown.
Varying the Hydrogen Bonding Strength in Phenolic/PEO‐b‐PLA Blends Provides Mesoporous Carbons Having Large Accessible Pores Suitable for Energy Storage
Authors: Li Jheng‐Guang , Lee Po‐Yuan , Ahmed Mahmoud M. M. , Mohamed Mohamed Gamal , Kuo Shiao‐Wei 
Published: April 2020

AbstractIn this study, mesoporous carbons are prepared by using a resol‐type phenolic resin as the carbon source and poly(ethylene oxide‐b‐lactic acid) (PEO‐b‐PLA) copolymer as the template, with a process of thermal curing, calcination, carbonization, and activation. The structures of these mesoporous carbons are strongly influenced by the self‐assembled structures formed from phenolic/PEO‐b‐PLA blends, varying from double‐gyroid, to cylinder, and finally to spherical micelle structures upon increasing the phenolic concentrations. The large pores (>20 nm) and high surface areas (>1000 m2 g−1) of these activated mesoporous carbons arise because the phenolic resin interacts only with the PEO segment (i.e., not with the PLA segment) through hydrogen bonding; thus, the relative wall thickness of the phenolic matrix decreases after template removal (thereby increasing the pore size), similar to the behavior of the poly(ethylene oxide‐b‐styrene) template system. Furthermore, these mesoporous carbons display efficient energy storage capacities of up to 200 F g−1 at 5 mV s−1, with excellent stabilities after 5000 charge/discharge cycles at 20 A g−1. Thus, this facile approach provides large and well‐ordered mesoporous carbons suitable for energy storage applications.
Rare Variants in Specific Lysosomal Genes Are Associated With Parkinson's Disease
Authors: Hopfner Franziska , Mueller Stefanie H. , Szymczak Silke , Junge Olaf , Tittmann Lukas , May Sandra , Lohmann Katja , Grallert Harald , Lieb Wolfgang , Strauch Konstantin , Müller‐Nurasyid Martina , Berger Klaus , Schormair Barbara , Winkelmann Juliane , Mollenhauer Brit , Trenkwalder Claudia , Maetzler Walter , Berg Daniela , Kasten Meike , Klein Christine , Höglinger Günter U. , Gasser Thomas , Deuschl Günther , Franke André , Krawczak Michael , Dempfle Astrid , Kuhlenbäumer Gregor 
Published: April 2020

AbstractObjectiveImpaired lysosomal degradation of α‐synuclein and other cellular constituents may play an important role in Parkinson's disease (PD). Rare genetic variants in the glucocerebrosidase (GBA) gene were consistently associated with PD. Here we examine the association between rare variants in lysosomal candidate genes and PD.MethodsWe investigated the association between PD and rare genetic variants in 23 lysosomal candidate genes in 4096 patients with PD and an equal number of controls using pooled targeted next‐generation DNA sequencing. Genewise association of rare variants in cases or controls was analyzed using the optimized sequence kernel association test with Bonferroni correction for the 23 tested genes.ResultsWe confirm the association of rare variants in GBA with PD and report novel associations for rare variants in ATP13A2, LAMP1, TMEM175, and VPS13C.ConclusionRare variants in selected lysosomal genes, first and foremost GBA, are associated with PD. Rare variants in ATP13A2 and VPC13C previously linked to monogenic PD and more common variants in TMEM175 and VPS13C previously linked to sporadic PD in genome‐wide association studies are associated with PD. © 2020 International Parkinson and Movement Disorder Society
Low‐field 1H NMR spectroscopy: Factors impacting signal‐to‐noise ratio and experimental time in the context of mixed microstructure polyisoprenes
Authors: Minkler Michael J. , Kim Jung Min , Shinde Vinita V. , Beckingham Bryan S. 
Published: April 2020

AbstractLow‐cost, high‐accuracy characterization of polymeric materials is critical for satisfying societal demand for high‐quality materials with ultra‐specific requirements. Low‐field nuclear magnetic resonance (NMR) spectroscopy presents an opportunity to replace costlier or destructive methods while utilizing nondeuterated solvents. Many factors play key roles in the ability of low‐field NMR spectroscopy to accurately analyze polymer systems. Sample characteristics such as polymer concentration, composition, and molecular weight all directly affect the capability of low‐field spectrometers to accurately determine polymer microstructure compositions. In addition to inherent sample properties affecting instrumental accuracy, many choices concerning instrumental parameters (including number of scans, relaxation delay, spectral width, and points per scan) must be made that impact the quality of the resulting NMR spectra. In this work, we benchmark the capability of a 60‐MHz low‐field NMR spectrometer for analyzing polymer materials using mixed microstructure polyisoprenes as a model polymer system of interest. The aforementioned critical sample and instrumental variables are varied, and we report on the ability to quantitatively characterize polyisoprene microstructure to within 1–2% of a higher field NMR spectrometer (400 MHz). We anticipate our findings to be generally applicable to other low‐field spectrometers of similar field strength and other polymer systems.
Optimization with nonstationary, nonlinear monolithic fluid‐structure interaction
Authors: Wick Thomas , Wollner Winnifried 
Published: April 2020

SummaryWithin this work, we consider optimization settings for nonlinear, nonstationary fluid‐structure interaction (FSI). The problem is formulated in a monolithic fashion using the arbitrary Lagrangian‐Eulerian framework to set‐up the fluid‐structure forward problem. In the optimization approach, either optimal control or optimal design problems are treated. In the latter, the stiffness of the solid is estimated from given reference values. In the numerical solution, the optimization problem is solved with a gradient‐based solution algorithm. The nonlinear subproblems of the FSI forward problem are solved with a Newton method including line search. Specifically, we will formally provide the backward‐in‐time running adjoint state used for gradient computations. Our algorithmic developments are demonstrated with some numerical examples as, for instance, extensions of the well‐known fluid‐structure benchmark settings and a flapping membrane test in a channel flow with elastic walls.
Incidence of Depression and First‐Line Antidepressant Therapy in People with Obesity and Depression in Primary Care
Authors: Tyrer Freya , Zaccardi Francesco , Khunti Kamlesh , Morriss Richard 
Published: April 2020

ObjectiveThe aim of this study was to describe the age‐ and gender‐specific incidence of depression, the dose‐response relationship between BMI and risk of depression (Cox proportional hazards), and antidepressant drug prescribing in adults with overweight or obesity.MethodsA retrospective electronic health record study using the Clinical Practice Research Datalink was conducted to identify adults with overweight and obesity (≥ 18 years) with incident depression (no prior depression diagnosis in their records), followed up from 2000 to 2019.ResultsAmong 519,513 adults, incidence of depression was 9.2 per 1,000 person‐years and was higher in women and in 40‐ to 59‐year‐old men who had severe obesity. Compared with having overweight, the hazard of depression increased with each BMI category as follows: 1.13 (30‐34 kg/m2; 95% CI: 1.10‐1.16), 1.34 (35‐39 kg/m2; 1.29‐1.40), 1.51 (40‐44 kg/m2; 1.41‐1.61), and 1.67 (45‐49 kg/m2; 1.48‐1.87), attenuating at BMI 50+ kg/m2 (1.54; 2.91‐1.84). Antidepressants were prescribed as first‐line therapy in two‐thirds (66.3%) of cases. Prescriptions for fluoxetine reduced over time (20.4% [2000]; 8.8% [2018]), and prescriptions for sertraline increased (4.3% [2000]; 38.9% [2018]).ConclusionsWe recommend guidance on antidepressant drug prescribing and specific services for people with obesity and depression that address both symptoms and behaviors.
A new database and benchmark of the bond energies of noble‐gas‐containing molecules
Authors: Tsai Cheng‐Cheng , Tsai Zhi‐Yao , Tseng Ming‐Yu , Hu Wei‐Ping 
Published: April 2020

AbstractWe have developed a new database of structures and bond energies of 59 noble‐gas‐containing molecules. The structures were calculated by CCSD(T)/aug‐cc‐pVTZ methods and the bond energies were obtained using the CCSD(T)/complete basis set method. Many wavefunction‐based and density functional theory methods have been benchmarked against the 59 accurate bond energies. Our results show that the MPW1B95, B2GP‐PLYP, and DSD‐BLYP functionals with the aug‐cc‐pVTZ basis set excel in predicting the bond energies of noble‐gas molecules with mean unsigned errors (MUEs) of 2.0 to 2.1 kcal/mol. When combinations of Dunning's basis sets are used, the MPW1B95, B2GP‐PLYP, DSD‐BLYP, and BMK functionals give significantly lower MUEs of 1.6 to 1.9 kcal/mol. Doubly hybrid methods using B2GP‐PLYP and DSD‐BLYP functionals and MP2 calculation also provide satisfactory accuracy with MUEs of 1.4 to 1.5 kcal/mol. If the Ng bond energies and the total atomization energies of a group of 109 main‐group molecules are considered at the same time, the MPW1B95/aug‐cc‐pVTZ single‐level method (MUE = 2.7 kcal/mol) and the B2GP‐PLYP and DSD‐PLYP functionals with combinations of basis sets or using the doubly hybrid method (MUEs = 1.9‐2.2 kcal/mol) give the overall best result.
Effects of Dopants in PtSn/M‐Silicalite‐1 on Structural Property and on Catalytic Propane Dehydrogenation Performance
Authors: Zhou Shuai , Liu Shuangfei , Jing Fangli , Jiang Changzhou , Shen Jun , Pang Yanping , Luo Shizhong , Chu Wei 
Published: April 2020

AbstractThe various metal‐doped Silicalite‐1 (M−S1, M=Mg, Al, Fe and In) supports were prepared by hydrothermal synthesis method, then were used to disperse the PtSn species through impregnation. The resulting solids were further characterized through XRD, N2 adsorption/desorption isotherms, XPS, H2‐TPR, NH3‐TPD, Raman spectroscopy and TG techniques to investigate the structural property before and after propane dehydrogenation reaction. The results exhibited that the introduction of various metal dopants had profound effects on pore structure, reducibility, acidity and surface content of Pt which was directly related to the activation of propane. And the surface content of Pt acted as the dominant role for converting propane. As a consequence, the maximum initial conversion of propane was obtained over Fe‐modified PtSn/Fe−S1 sample, but it deactivated fast as well because of the coke deposition.
Comparison of two reinforcement rings for primary total hip arthroplasty addressing displaced acetabular fractures: a biomechanical analysis
Authors: Becker Johannes , Winkler M. , von Rüden C. , Bliven E. , Augat P. , Resch H. 
Published: April 2020

Abstract
Introduction
Aim of this study was to biomechanically compare two different acetabular cup fixation constructs in terms of fracture fixation for displaced acetabular fractures involving the anterior column with hemitransverse fracture under partial and full weight-bearing conditions.

Methods
Two different reinforcement rings designed as cages for primary THA were biomechanically tested in terms of managing a complex acetabular fracture. Single-leg stance cyclic loading was performed to assess fracture gap movement and fragment rotation. Twelve hemi pelvis Sawbones were divided into two groups: primary THA with acetabulum roof reinforcement plate (ARRP) (n = 6) and primary THA with Burch–Schneider reinforcement cage (BSRC) (n = 6).

Results
During loading under partial weight-bearing (250 N) fracture gap movement tended to be larger in the BSRC group as compared to the ARRP group. Under full weight-bearing conditions, the ARRP showed 60% significantly less motion (p = 0.035) of the os ilium to os ischii gap compared to BSRC. Fracture gap movements between the os ilium and spina iliaca fragments were significantly reduced by 76% (p = 0.048) for ARRP in contrast to BSRC. The ARRP group also demonstrated significantly less movement in the fracture gaps os ischii to quadrilateral plate (62% reduction, p = 0.009) and quadrilateral plate to spina iliaca (87% reduction, p < 0.001). Significantly less rotational movement of the quadrilateral plate to the os ilium was exhibited by the ARRP group (p = 0.015).

Conclusions
The presented acetabulum roof-reinforcement plate (ARRP) provides stable conditions at the acetabular component with adequate stabilization of a displaced acetabular fracture.
Knowledge transfer as a tool towards improvement of cancer care in low- and middle-income countries. 6th European Roundtable Meeting (ERTM), June 14th, 2019, Berlin, Germany
Authors: Ortmann O. , Torode J. , Schmiegel W. , Thomssen C. , Hakama M. , Basu P. , Ringborg U. , Helbig U. ,   For the participants of the ERTM, Hakama Matti , Basu Partha , Jelenc Marjetka , Borras Josep , Ringborg Ulrik , Torode Julie , Coebergh Jan-Willem , Bruns Johannes , Follmann Markus , Helbig Ulrike , Hochhaus Andreas , Klinkhammer- Monika , Landenberger Margarete , Ortmann Olaf , Schmiegel Wolff , Thomssen Christian 
Published: April 2020

Abstract
Purpose
To identify key factors for the best practice of knowledge transfer from high-income settings to low- and middle-income settings.

Results
Interactive sessions led to the identification of European learnings that can and should be shared beyond Europe. Furthermore, methods were characterised which may lead to successful knowledge transfer with subsequent quality improvement.

Conclusion
To ensure successful implementation of knowledge and new methods, political support is extremely important. A strong focus should be an improvement of collaboration and network development. Rehabilitation, early and late pallative care, cost effectiveness and long-term follow-up are priorities. Limitations are budget constraints which limit the execution of NCCPs.
Efficacy and safety of Dentoxol® in the prevention of radiation-induced oral mucositis in head and neck cancer patients (ESDOM): a randomized, multicenter, double-blind, placebo-controlled, phase II trial
Authors: Lalla Rajesh V. , Solé Sebastián , Becerra Sergio , Carvajal Claudia , Bettoli Piero , Letelier Hernán , Santini Alejandro , Vargas Lorena , Cifuentes Alexander , Larsen Francisco , Jara Natalia , Oyarzún Jorge , Feinn Richard , Bustamante Eva , Martínez Benjamín , Rosenberg David , Galván Tomas 
Published: April 2020

Abstract
Purpose
The aim of this study was to assess the efficacy and safety of Dentoxol mouthrinse in reducing the severity of oral mucositis (OM) secondary to radiation therapy (RT) for head and neck cancer.

Methods
A randomized, double-blind, placebo-controlled, multicenter phase II clinical trial was conducted. Subjects were asked to use Dentoxol (n = 55) or control (n = 53) mouthrinse 5 times/day during RT. Twice a week, OM was assessed clinically using the WHO scale and the Oral Mucositis Daily Questionnaire (OMDQ) was completed.

Results
The incidence of severe OM was 40.7% in the Dentoxol group and 51% in the control group (p = 0.265). Comparing all recorded clinical assessments, severe OM was seen in 13.3% of all assessments in the Dentoxol group vs. 21.8% in the control group (p = 0.000). There was a statistically significant lower proportion of assessments showing severe OM in the Dentoxol group at weeks 4, 5, and 6 of RT. The mean duration of severe OM was 11.95 days in the Dentoxol group vs. 14.59 days in the control group (p = 0.502). There was no difference between groups in mouth pain and its impact on function. The use of Dentoxol was safe and was not linked to any serious adverse events.

Conclusion
The use of Dentoxol 5 times/day is safe and resulted in significantly fewer time-points with severe OM and a delay in the onset of severe OM, compared with a control rinse. A phase III clinical trial is warranted to confirm efficacy and address the limitations of this study.