bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION IN THE TREATMENT OF PATIENTS WITH HEPATOCELLULAR CARCINOMA ON ADVANCED LIVER CIRRHOSIS
Authors: Polekhin A. S. , Tarazov P. G. , Polikarpov A. A. , Granov D. A. 
Published: March 2020

OBJECTIVE was to evaluate the results of transcatheter arterial chemoembolization (TACE) in the treatment of patients with hepatocellular carcinoma (HCC) on advanced liver cirrhosis (LC) and intermediate stage (B) according to BCLC classification (Barcelona Clinic Liver Cancer classification).METHODS AND MATERIALS. We evaluated results of TACE in 54 patients. Of them, 12 (22 %) had stage A of cirrhosis and 42 (78 %) – stage B of cirrhosis according to the Child-Pugh score. Nine (17 %) patients matched stage A4 and 45 (83 %) – stage В according to BCLC classification. The TACEs was performed according to the conventional practice with using Lipiodol + gelfoam (n=40) and with a drug-eluting beads (n=14) from 1 to 16 (average 6) times. The Doxorubicin was used as a first-line therapy in all cases.RESULTS. After TACE, two patients died of liver failure (3.7 %). According to the m-RECIST, complete response to treatment was observed in 9 (16.5 %), partial response – in 13 (24 %), stabilization – in 19 (35.5 %) and progression – in 13 (24 %) patients. At present, 22 (41 %) patients are alive for 1 to 51 (average 16.2) months. 32 patients (59 %) died between 2 to 62 months: 13 (24 %) – from HCC progression, 19 (35 %) – from liver failure. The 1– 2–3-year survival rate was 75–44–15 %; only one patient survived > 5 years. The median survival rate was (22.0±3.0) months, overall survival rate according to Kaplan – Meier was 26 months.CONCLUSION. TACE is a relatively safe and effective treatment in patients with HCC on advanced LC and intermediate stage (B).
ENDOVASCULAR TREATMENT OF PATIENTS WITH ACUTE THROMBOEMBOLIC OCCLUSION OF THE SUPERIOR MESENTERIC ARTERY
Authors: Khripun A. I. , Mironkov A. B. , Pryamikov A. D. , Tyurin I. N. , Alimov A. N. , Agasyan G. A. 
Published: March 2020

THE OBJECTIVEwas to report our experience of endovascular treatment in patients with acute thromboembolic occlusion of the superior mesenteric artery (SMA).METHODS AND MATERIALS. 13 patients with acute thromboembolic occlusion of the SMA underwent endovascular intervention. There were 4 (31 %) men and 9 (69 %) women. The average age was 76±9 years. The time from the beginning of the disorder to intervention and mechanical reperfusion of the SMA ranged from 4 to 65 hours, averaging (22±17) hours. Initial leukocytosis was (16.5±5.8)·10/9 l (from 9.2 to 28.8·10/9 l). Various endovascular manipulations were applied to achieve artery reperfusion: mechanical recanalization, balloon angioplasty, aspiration thrombectomy and stenting.RESULTS. Complete recovery of antegrade blood flow through the SMA and its main branches was achieved at all 13 (100 %) patients. Laparotomy was executed at 4 (31 %) patients, thus the intestinal necrosis after endovascular intervention developed in 3 (23 %) cases. The lethal outcome was 46 %. The main reason for a lethal outcome was reperfusion syndrome (4 patients, 31 %).CONCLUSION. Endovascular methods of treatment of patients with acute thromboembolic occlusion of the SMA can be considered as the first step in medical algorithm. They allow to save intestinal viability in most patients. Reperfusion syndrome was the main reason for a lethal outcome. The development of methods for the prevention and treatment of reperfusion syndrome in acute thromboembolic occlusion of the SMA has to become the basis for successful treatment of these patients.
A JUDICIALIZAÇÃO DA ASSISTÊNCIA FARMACÊUTICA AO PACIENTE DIABÉTICO NO ESTADO DO PARÁ: 10 ANOS DA AÇÃO CIVIL PÚBLICA Nº 0006454-87.2008.4.01.3900.
Authors: Santos Andreza Casanova Von Grapp 
Published: March 2020

A pesquisa pretende analisar os efeitos da judicialização da assistência farmacêutica ao portador de Diabetes Mellitus no Estado do Pará tendo como referência a Ação Civil Pública n° 0006454-87.2008.4.01.3900 e verificar como as políticas públicas destinadas aos diabéticos evoluíram no período de 2008, quando a ação foi interposta, até a presente data. Será realizada pesquisa bibliográfica sobre a judicialização da saúde, federalismo, políticas públicas destinadas aos pacientes diabéticos e aplicação do princípio da responsabilidade solidária entre os entes federados e análise dos regulamentos expedidos pelo Ministério da Saúde que regulam o fornecimento de medicamentos aos diabéticos.
ПОРУШЕННЯ ТА ЗЛОВЖИВАННЯ В УПРАВЛІННІ ФІНАНСОВИМИ РЕСУРСАМИ НА МІСЦЕВОМУ РІВНІ В УМОВАХ ДЕЦЕНТРАЛІЗАЦІЇ
Authors: Voznyak Halyna 
Published: March 2020

В статті розглянуто основні форми порушень та зловживань, що виникають на різних рівнях управління місцевими фінансами (область, міста, райони, села, ОТГ) в процесі реалізації реформи децентралізації. Подано їх характеристику. Виявлено проблемні аспекти ефективного використання коштів місцевих бюджетів ОТГ окремих областей Центральної України. З метою мінімізації фінансових зловживань та порушень на місцевому рівні, запропоновано низку практичних рекомендацій в частині: удосконалення системи внутрішнього контролю; нормативно-правового забезпечення; запровадження наскрізного моніторингу рішень ОТГ; належного планування потреби бюджетних коштів та формування єдиної інформаційної бази, що фіксує виявлені правопорушення, пов’язані із управлінням коштами місцевих бюджетів.
СУСПІЛЬНО-ЕКОНОМІЧНІ ПОГЛЯДИ Г. С. СКОВОРОДИ
Authors: Strishenez Nicholas , Pavlova Elena , Pavlov Constantine 
Published: March 2020

У статті здійснено аналіз праць Г. С. Сковороди, в яких висвітлюються питання господарського та суспільного розвитку переважно Слобідської України. З’ясовано його погляди щодо економіки, досліджено зміст концепції “споріднена” праця, котра розглядається мислителем як важливий засіб досягнення благополуччя і щастя кожною людиною.
У вченні Г. С. Сковороди відбився протест українського народу проти пригнічення та несправедливості, показано настрої трудових мас, моральна чистота їх прагнень. Його твори пройняті пафосом критики несправедливості, вад українського суспільства ХУІІІ ст. Безкомпромісність Григорія Савича, його послідовність у відстоюванні своїх переконань, життєве кредо служать прикладом для нащадків.
ФІЛОСОФСЬКІ ДЕТЕРМІНАНТИ ФІНАНСОВОЇ БЕЗПЕКИ АКЦІОНЕРНИХ ТОВАРИСТВ
Authors: Stashchuk Olena 
Published: March 2020

У статті встановлено, що фінансова безпека акціонерних товариств є поняттям міждисциплінарним, а її сутність визначається широким діапазоном концепцій крізь призму дослідження фінансової безпеки як економічного, суспільного та філософського явища. Доведено, що проблематика вибору найбільш прийнятної методології дослідження фінансової безпеки акціонерних товариств тісно взаємопов’язана із окремими філософськими детермінантами системи забезпечення фінансової безпеки корпоративних структур. Систематизовано основні філософські детермінанти, які властиві фінансовій безпеці акціонерних товариств: фінансова безпека як категорія надбудови, взаємодія зовнішнього та внутрішнього, детермінованість явища, єдність теорії та практики. Запропоновано авторський підхід до розуміння таких детермінант та особливостей їх застосування у процесі наукового пізнання фінансової безпеки акціонерних товариств.
Analysis Of Communication Process In Counseling Through Whatsapp
Authors: Suryahadikusumah Ahmad Rofi , Diana Diana 
Published: March 2020

Konseling melalui WhatsApp menjadi trend dalam praktik konseling di sekolah. Banyak penelitian mengenai pengembangan model konseling melalui WhatsApp dan menguji efektifitasnya, sementara kajian terhadap proses konselingnya belum tersentuh oleh sebuah riset. Di lain pihak, banyak yang masih meragukan kebenaran proses komunikasi yang terjadi dalam WhatsApp merupakan proses komunikasi konseling. Penelitian bertujuan untuk menganalisis proses komunikasi konseling yang merujuk kepada dimensi komunikasi efektif dalam konseling. pendekatan mix method digunakan dengan one phase design. Penelitian dilakukan kepada 25 responden yang merupakan siswa SMK PGRI 2 Palembang yang memanfaatkan konseling melalui WhatsApp di sekolah tersebut. Metode kuantitatif digunaka untuk mensurvey ketercapaian aspek komunikasi dalam konseling melalui WhatsApp, sedangkan metode kualitatif digunakan untuk mendalami pola komunikasi yang terjadi. Hasil penelitian menunjukkan bahwa aspek rasa nyaman dan keterbukaan merupakan pengalaman yang paling dirasakan responden, sedangkan 50 % responden mengakui kurang merasakan dimensi empati. Penelitian merekomendasikan untuk1) tetap menggunakan prinsip dalam konseling dalam konseling melalui WhatsApp, terutama dalam pembentukan rapport,2) memahami penggunaan kata – kata , emoticon, dan gaya bahasa dalam komunikasi digital, 3) mengggunakan pendekatan naratif dan solution focused ketika melakukan konseling melalui WhatsApp. Kata kunci: komunikasi konseling, WhatsAppAbstract: Counseling through WhatsApp has become a trend in counseling practices in schools. Much research on the development of counseling models through WhatsApp and its effectiveness is discussed, while the study of the counseling process has not been touched by a study. On the other hand, many still doubt the communication process that occurs in WhatsApp is a counseling communication process. Research aim to analyze counseling communication processes that discuss the dimensions of effective communication in counseling. The mixed method is used with a one-phase design. The study was conducted on 25 respondents who were students of SMK PGRI 2 Palembang who use counseling through WhatsApp at their school. Quantitative methods used for surveying aspects of communication in counseling through WhatsApp, while qualitative methods are used to explore patterns of communication that occur. The results showed that the aspects of comfort and openness were the most considered experiences of respondents, while 50% of respondents considered lacking the empathy dimension. Research recomendating to 1) use principles in counseling in WhatsApp counseling, especially in rapport relations, 2) mastering the use of words, emoticons, and language styles in digital communication, 3) use narrative approaches and solutions focused on compiling counseling through WhatsApp.
Nanotechnology teaching material for junior high school chemistry teaching: Design research approach
Authors: Kolehmainen Kati , Pernaa Johannes , Aksela Maija 
Published: March 2020

The aim of this research was to design nanotechnology teaching material that is interesting to the pupils, and brings out the significance of chemistry and technology in society as well as supports the development of scientific literacy. The research was conducted as a design research that included four phases: 1) theoretical problem analysis, 2) design, 3) design outcome and its evaluation, and 4) further development of the outcome. During the theoretical problem analysis, previous research literature was studied and design goals for this research were set. According to previous research, it was noted that students are interested in visualizations of nanotechnology and its applications in everyday life. The designed material was an educational video because the aim was to make it technically usable and easily distributed. The material is being distributed to the users through interactive blog.
Based on previous research, visualizations of nanotechnology were chosen as the central design theme for the material. The evaluation of the outcome was also based on the same theme. The material was evaluated by a qualitative case study, the data for which was gathered through research interviews. The evaluators were students, aged 16 to 19, from whom information was gathered on how interesting the designed material was and why it was interesting to them. Based on the evaluation, macro-scale visualizations were the most interesting because they helped in conceiving the size scale. Also visualizations of nanotechnological structures and its everyday applications interested the students. Structural visualizations helped in conceiving the structures of materials and everyday visualizations were familiar from their own life, which was considered motivating. Based on this research, it can be noted that nanotechnology is an interesting, interdisciplinary subject, which is well suitable to be integrated into chemistry teaching. The designed material is freely available for everyone online: http://nanoteknologia.blogspot.fi.
Plant pigments as pH indicators in cooking
Authors: Motturi Heli , Slawuta Sari , Salkunen Sirpa , Rajala Petra 
Published: March 2020

Controlling acidity comes up often during cooking. Food’s acidity can be discussed in connection to using vinegar, marinade or baking soda in cooking. One seldom considers that acidity affects the food’s colour and thus its appeal. Colour is especially significant for ready-made foods. Berry jam or juice that is too pale or too dark does not look fresh or appealing. Many of the foods that lose their colour easily contain nature’s own pH indicators, anthocyanins.
The workshop detailed in this article explores discolouration of anthocyanins with the help of different methods. Anthocyanins offer many points of discussion for chemistry classes, because in addition to their indicator properties, anthocyanins are also flavonoids and food additives. The work instructions are mainly aimed at grades 7 to 9. The chemistry part involving anthocyanins is suitable for upper secondary school as well, since it is challenging. The article details a demonstration that motivates towards inquiry-based work and two alternative work instructions.
Establishing murine models of hepatocellular carcinoma using NOD/SCID, nude and Balb/c mice: An initial comparative study
Authors: Do Nghia Minh , Nguyen Sinh Truong , Vo Phuc Hong , Nguyen Trinh Thi – Tu , Truong Kiet Dinh , Pham Phuc Van 
Published: March 2020

Introduction: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality in the world. Therefore, more and more studies are developing novel therapies to treat this disease. The pre-clinical trials on animals are a vital step to evaluate the efficacy as well as side effects of these novel therapies. Hence, this study aimed to develop the murine model of HCC using 3 kinds of mice: NOD/SCID, nude and Balb/c mice.
Methods: HCC cell line HepG2 was used in this study. They were injected into 3 kinds of mice: NOD/SCID, nude and Balb/c mice at three doses: 5 x 106, 2.5 x 106, and 1.25 x 106 cells. Tumor size and body weight of the mice were recorded daily. To confirm these tumors in mice as malignant tumors, they were removed and analyzed by histopathology.
Results: The results showed that in nude mice, the tumors appeared after 1 day of injection and could be detected by the naked eye; they continuously developed until the end of the study. In NOD/SCID mice, the tumors could be detected by the naked eye after 3 days of injection; their sizes also increased until the end of the experimental study. Meanwhile, in Balb/c mice, although the tumors could be observed by the naked eye on the 3rd day after cell injection, they regressed and markedly disappeared after 30 days. The dose of 5 x 106 cells per mouse induced the largest tumors (1.2 cm in diameter) in NOD/SCID mice. The histopathological analysis showed that the tumors collected from nude and NOD/SCID mice also displayed the poorly differentiated malignant carcinoma with muscle tissue invasion.
Conclusion: Both nude and NOD/SCID mice are appropriate for future studies to establish HCC murine models using HepG2 injection.
«КНИЖНИК-REVIEW» – ЧАСОПИС ФАХОВОЇ КНИЖКОВОЇ ЖУРНАЛІСТИКИ
Authors: Skiban O. 
Published: March 2020

<p><em>The article describes the main typological characteristics of the literary-publishing journal Scribe-Review (SR), published in Ukraine during 2000–2009. The thematic-rubric complex of the publication and author’s composition is analyzed. Particular attention is focused to study the issues of the literary and publishing process of that time, including the reflection of it on the pages of the Scribe-Review. The evolution of the edition from the newspaper Scribal format to the full-color glossy Scribe-Review (SR), an edition about all books and all writers, has been considered.</em></p><p><em>The magazine Scribe-Review (SR) is described as the only founder of the rating «Book of the Year» in Ukraine, not only as a literary event but also as a nationwide one. The magazine’s expert evaluations, led by its editor-in-chief Konstantin Rodik, determined the best books in various categories (from fiction, non-fiction to specialist publications).</em></p><p><em>The work of the editor-in-chief of the journal Konstantin Rodyk is analyzed, which is considered by modern scholars to be an example of quality book journalism.</em></p><p><em>The focus is also on the semantics of the terms «book journalism», «book journalism». Based on the materials of quality book journalism presented on the pages of the Scribe-Review (SR), we will try to identify its most prominent features, express problems, trace conceptual phenomena.</em></p><p><em>Particular attention was paid to the review and processing of the issue of the Scribe-Review (SR). Its main typological characteristics are described: the author’s composition, artistic and technical design and thematic-rubric content. Content analysis of information and analytical materials of different types and genres is carried out. The magazine is presented as a model for the establishment of a «school of book journalism», which can serve as a reference example for information and communication platforms and modern media. The peculiarities of the introduction of a new discursive practice into the pages Scribe-Review (KR) are shown – cultural journalism, book journalism.</em></p><p><em>During the research the following scientific methods were used: systematic, terminological analysis, contextual, communication, method of content analysis, comparative, historical.</em></p><p><strong><em>Key words:</em></strong> <em>book journalism, professional press, book magazine, information policy of media, channels and means of promotion, magazine Scribe-Review.</em></p><p><strong> </strong></p>
ВИВЧЕННЯ УКРАЇНСЬКОЇ КНИГИ ЯК СОЦІАЛЬНО-КОМУНІКАЦІЙНОГО ФЕНОМЕНУ В ПЕРІОД 1917–1920-Х РОКІВ
Authors: Leontieva T. 
Published: March 2020

<p><em>The basic characteristics of the historical period of the beginning of the study of the Ukrainian book as a social-communication phenomenon in Ukraine (at that time – the Ukrainian SSR) in reference to 1917–1920-ies are analyzed. On the example of some publications of the «Knyzhnyk» («Bibliognost»), «Knyha» («Book»), «Knyzhka» («Book») journals, and also taking into account discussions between Ukrainian bibliographers M. Kufaiev and D. Balyka, it was concluded about the genesis of the vision of the Ukrainian book as a social-communication phenomenon in this very period.</em></p><p><em>It is emphasized that this period was a turning point in the study of many social-communication characteristics of the Ukrainian book. First of all, this concerns the problems of the typological structure of the book market and the auditory factor of the book’s functioning as a social-communication phenomenon. Publications in the «Knyzhnyk» («Bibliognost»), «Knyha» («Book»), «Knyzhka» («Book») journals started a professional discussion on problems of text preparation, publications design and their distribution. Two approaches to studying the Ukrainian book were distinguished: of M. Kufaiev, who believed that the book was a striking expression of the social-communication characteristics of mass communication, and of D. Balyka, who insisted on the need to take into account first and foremost the sociological features of the book’s circulation as a mass communication product.</em></p><p><em>It is emphasized that the scientific concept of the science of social communications – the study of the book as a social-communication phenomenon – is developing. Most of the provisions of this concept were formed by the theorists of journalism and publishing in the 1920s, and these provisions have considerable theoretical and historiographical value. They can serve as a basis for modern developments in the field of social communication science.</em></p><p><strong><em>Key words:</em></strong><em> author, audience, journal, publications, publisher, book, communication, society.</em></p>
ЗАСТОСУВАННЯ МУЛЬТИМЕДІЙНИХ ТЕХНОЛОГІЙ ДЛЯ СТВОРЕННЯ ЕЛЕКТРОННОГО НАВЧАЛЬНОГО ВИДАННЯ
Authors: Figol N. , Chykaliuk E. 
Published: March 2020

<p><em>One of the main ways to reorganize the educational process in the field of education and science is to make changes related to rapid technological progress. A priority for teachers is the need to keep the student's attention on new material and meet his / her needs for constantly updated, up-to-date information. The leading tool in achieving these goals is the digitization of the educational process: it involves the translation of content in all its forms - text, graphics, audio - in a digital format, which makes it easy to transport the material of offline publications by any channel of electronic communication.</em></p><p><em>The purpose of this work is to determine the functionality of the multimedia environment in the process of editorial preparation of e-learning publications in foreign experience. The stated purpose implies the fulfillment of the following tasks: analyze the selected e-learning edition and determine the list of basic multimedia elements.</em></p><p><em>Research methods. Due to the multidimensionality of the chosen topic, such methods as the method of terminological analysis was used to develop the conceptual apparatus; synthesis method - to identify the foundations of editorial training multimedia educational publications; methods of analogy and systematization - to characterize trends in the development of multimedia publications; a descriptive method for presenting an analysis of a selected publication and a comparative method for identifying features of multimedia educational publications and comparing them with traditional (paper) counterparts. The scientific novelty of the work is to determine the methodology of editing the multimedia textbook for college students and students, as well as to evaluate the functionality of the multimedia publication, its features and methods of preparation.</em></p><p><strong><em>Key words:</em></strong><em> e-learning publication, multimedia, multimedia educational publication, editing.</em></p><p> </p>