bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in diabetic cardiomyopathy: current and potential management strategies and emerging biomarkers
Authors: Hassooni Furqan Ridha Hassooni , Aljubori Eathar , Abbas Ghadeer Mohammed Abbas , Dheyab Athraa Yaseen Dheyab , Abdulatif Mohammed Qutaiba Abdulatif , Sadeq Sadeq Maram A. , Budair Ahmed , Alturshan Ali , Enad Ayat Hussein , Mohammed Asmaa Jasim , Hassan Ghadeer Ali , Yaqoob Zinah Qasim Yaqoob , Prajjwal Priyadarshi , Jain Hritvik , Goyal Aman , Amir Omniat 
Published: December 2024

Background:
Diabetic cardiomyopathy (DCM) is a significant complication of diabetes mellitus (DM) and a major contributor to heart failure (HF). Despite its prevalence and impact, there is a notable lack of targeted therapies, highlighting the need for ongoing research into novel treatment strategies. Current management primarily involves blood sugar control, lifestyle modifications, and addressing risk factors. Conventional treatments, including Renin-angiotensin-aldosterone system (RAAS) inhibitors, angiotensin receptor/neprilysin inhibitor, beta-blockers, ivabradine, and vericiguat, are also employed.

Methodology:
A comprehensive search was made using PubMed, Scopus, and Google Scholar for studies published. The search focused on DCM, therapeutic strategies, and emerging biomarkers. Articles were selected based on relevance, study quality, and inclusion criteria, which emphasized peer-reviewed studies on DCM management and biomarker identification.

Results and discussion:
Our review reveals that targeting oxidative stress through these antioxidant therapies offers a promising approach for limiting DCM progression. Clinical trials provide evidence supporting the efficacy of these agents in reducing oxidative damage and improving cardiac function in diabetes-induced cardiomyopathy.

Conclusion:
The current landscape of DCM management highlights the need for novel therapeutic strategies and early detection methods. Antioxidant therapies show potential for addressing the oxidative stress that underlies DCM, and ongoing research into emerging biomarkers may offer new avenues for early diagnosis and treatment.
Diagnostic challenges and management of kikuchi-fujimoto disease: a rare case report
Authors: Motwani Jatin , Kumar Ameet , Azhar Laiba , Qureshi Ayaan Ahmed , Fatima Zukhruf , Khalid Saif , Kumari Verkha , Mahmud Nishat Syeed 
Published: December 2024

Introduction:
Kikuchi-Fujimoto disease, otherwise referred to as histiocytic necrotizing lymphadenitis, is a rare and self-limiting disorder characterized by fever, lymphadenopathy, and upper respiratory symptoms. The main target of the illness is young Asian adults and is more prevalent in females. This disease probably has viral triggering or autoimmune responses, and diagnosis depends on histopathological examination.

Case Presentation:
We present a case of an 18-month history of recurrent high-grade fever with marked weight loss and an enlarged occipital lymph node in a 42-year-old diabetic male from Karachi, Pakistan. The patient’s symptoms did not subside despite being hospitalized several times and receiving multiple courses of antibiotics. Physical examination revealed a firm, non-tender occipital lymph node. Laboratory studies showed mild anemia and leukopenia, raised inflammatory markers, but unremarkable imaging studies and autoimmune tests. An excisional biopsy of the lymph node confirmed KFD with necrotizing lymphadenitis showing characteristic karyorrhectic debris.

Discussion:
This case epitomizes the diagnostic challenges of KFD, which can mimic a host of conditions like tuberculosis and lymphoma. The recurrent fevers in the presence of significant weight loss and failure to respond to the usual treatments raised suspicion for further detailed investigation. Excisional biopsy established the diagnosis and differentiated it from other conditions. The patient’s rapid improvement with corticosteroid therapy aligns with established treatment protocols for KFD, thus proving its efficacy.

Conclusion:
KFD should be included in the differential diagnosis of fever of unknown origin. Diagnosis and management of KFD can avoid misdiagnosis and hence improve patient outcomes.
Diagnostic challenges of tailgut cysts: a case report on an occult perianal mass
Authors: Khalid Faraz , Naveed Haris , Ali Masab , Ansari Muhammad Saad , Shafiq Muhammad Sajjad , Ahmad Muhammad Husnain 
Published: December 2024

Introduction:
Tailgut cysts, or retro-rectal cystic hamartomas, are rare congenital lesions arising from embryonic hindgut remnants, typically located in the retro-rectal area. These cysts present some diagnostic challenges due to vague symptoms and potential for malignancy.

Case presentation:
A 25-year-old female presented with a 5-year history of perianal swelling. MRI revealed a T2 hyperintense, multiseptated cystic lesion suggestive of a tailgut cyst. The cyst was surgically excised via a trans-sacral approach, and the specimen was sent for histopathological analysis.

Clinical discussion:
The MRI findings were confirmed by histopathology, identifying a benign tailgut cyst. The patient had an uneventful recovery and was symptom-free at the 2-month follow-up.

Conclusion:
Tailgut cysts can mimic other perianal masses, complicating diagnosis. Accurate diagnosis and successful treatment rely on clinical vigilance, advanced imaging, and histopathological confirmation. Early surgical resection is crucial to prevent complications, including malignancy.
Prevalence of chronic respiratory diseases diagnosed by pulmonary function testing: a cross-sectional study
Authors: Alnoor Sarah Abualgasim Musa , Elhag Omer Elgaili Yousif , Ali Najlaa Mohammed Abass , Yousif Yousif Omer Elgaili , Mohamed Asmaa Abdelmaged Eltaieb , Saad Awab Hashim Sulieman , Mohamed Amro Abdalmageed Altayeb 
Published: December 2024

Background:
Respiratory diseases are pathological conditions affecting the organs and tissues involved in gas exchange. Pulmonary function tests allow for the classification of the severity of respiratory diseases, their follow-up, and treatment response assessment. The aim was to determine the prevalence of chronic respiratory disease and the risk factors in Khartoum, Sudan.

Methods:
A descriptive cross-sectional hospital-based study was conducted in the Respiratory Department from May to October 2021, including the patients who underwent pulmonary function tests. Data were analyzed using Statistical Package for Social Sciences, version 25.0.

Results:
Out of the 396 study participants, 214 (54%) were above 40 years of age with similar gender distribution and a male-to-female ratio of 1.1: 1, and almost all were Sudanese. Clinically, 40.4% had normal body mass index (BMI), 24.2% underweight, and 13.6% were obese. Smokers represented 19.4% of the study participants. Moreover, 18.2% reported a positive history of bronchial asthma. Regarding pulmonary function test patterns, 50.8% exhibited normal results, 25.3% displayed restrictive patterns, 19.7% showed obstructive patterns, and 4.3% had mixed patterns. Chi-square cross-tabulation testing revealed a significant association between older ages of participants and the abnormal pulmonary function test results (P < 0.001).

Conclusion:
The study revealed that the proportion of respiratory diseases with abnormal lung function test results is considerable and should not be ignored, especially among older patients. Therefore, when indicated, attention should be paid to performing lung function tests widely to accurately identify the prevalence rates of lung diseases and associated risk factors in Sudan.
Relationship Between Posttraumatic Growth and Illness Uncertainty in Young Women With Breast Cancer: The Mediating Role of Self-compassion
Authors: Uğuz Özkan , Dogan Satı 
Published: December 2024

Background
The recovery process for young women with breast cancer is influenced by several factors, including the uncertainty of disease, posttraumatic growth, and self-compassion.

Objective
To examine the association between illness uncertainty and posttraumatic growth in young women with breast cancer and to determine the mediating role of self-compassion in this association.

Methods
This cross-sectional, descriptive and correlational study was conducted in Western Turkey between September 2023 and December 2023. Data were collected from 153 young women with breast cancer using the demographic and clinical questionnaire, the Posttraumatic Growth Inventory, Mishel Uncertainty in Illness Scale—Community, and the Self-compassion Scale.

Results
Posttraumatic growth was negatively correlated with illness uncertainty (r = −0.304, P < .001) and positively correlated with self-compassion (r = 0.581, P < .001). Illness uncertainty negatively predicted posttraumatic growth (P < .001), whereas self-compassion positively predicted posttraumatic growth (P < .001). When self-compassion was included in the model, the effect of illness uncertainty on posttraumatic growth became insignificant (P > .05).

Conclusion
Results of the study indicate that self-compassion has a fully mediating effect on the relationship between illness uncertainty and posttraumatic growth in young women with breast cancer.

Implications for Practice
Psychosocial care of young women with breast cancer by oncology nurses can significantly improve self-compassion, reduce illness uncertainty, and promote posttraumatic growth.
Transcutaneous auricular vagus nerve stimulation for functional gastrointestinal disorders: From understanding to application
Authors: Weng Mingyao , Wang Jiayue , Liu Yiran , Ou Shuangling , Xiang Jinyi , Huang Guanting , Xiong Jingnan , Wu Qiuyan , Zhou Yuhan , Zhou Hao , Wang Dan 
Published: December 2024

Abstract
Functional gastrointestinal disorders (FGIDs) are debilitating diseases of the digestive system that severely impair an individual’s quality of life and impose a significant economic burden. However, the mechanisms underlying the pathogenesis of FGIDs and effective treatment options remain unclear. Transcutaneous auricular vagus nerve stimulation (taVNS), a novel neuromodulation therapy, has shown promising therapeutic outcomes in the treatment of FGIDs. This study conducted a comprehensive analysis of the development of taVNS and its relationship with vagus nerve stimulation and explored the clinical application of taVNS in managing FGIDs, including functional dyspepsia, irritable bowel syndrome, and functional constipation. Additionally, this study investigated the pathophysiological mechanisms of taVNS in FGIDs and reviewed its application as a holistic treatment approach, aiming to provide new insights into its therapeutic potential.
Pharmacological activities and mechanisms of proteins and peptides derived from traditional Chinese medicine
Authors: Ni Yadi , Zhu Yuya , Xu Lingxin , Duan Jin’ao , Xiao Ping 
Published: December 2024

Abstract
Proteins and peptides are important active components of traditional Chinese medicine (TCM) widely found in plants, animals, and fungi. Modern research indicates that the protein constituents of TCM possess various pharmacological activities, including antitumor effect, immunomodulation, antioxidation, antihypertension, anti-inflammation, cardiovascular and nervous system protection, blood sugar regulation, and bacteriostasis effects. Despite significant progress in recent years regarding the pharmacological activities and mechanisms of TCM components, research on protein components of TCM has lagged. Many TCM protein components have yet to be effectively developed, and their pharmacological activities and mechanisms remain insufficiently elucidated. This article provides a comprehensive review of the pharmacological activities and mechanisms of TCM proteins and peptides. Additionally, the current shortcomings in research are discussed to offer some insights, aiming to promote further investigation of TCM proteins and peptides and facilitate their application in new drug development and clinical treatment.
Fungal positivity seen in tertiary care hospital during COVID-19 pandemic
Authors: Kaur Ravinder , Rawat Deepti , William Ashish , Singh Pradeep Kumar , Kandir Neelam S.S , Sharma Akanksha 
Published: December 2024

Coronavirus disease 2019 (COVID-19) pandemic has been prevailing for more than a year associated with increased number of opportunistic invasive fungal infections in patients who have been critically ill or immunocompromised. In this retrospective study, details of various clinical specimens received from suspected patients of fungal infections were studied. The fungal cultures were seen to be positive in 64% (51/79) COVID-19 positive patients and 43% (163/381) COVID-19 negative patients during the year 2021 in the second wave of COVID-19. Among COVID-19 infected patients, the fungal isolations mostly observed were Candida spp. (63%) followed by Aspergillus spp. (15% ) and Mucor spp. (6%). The maximum samples (17% - COVID-19 positive and 83% - COVID-19 negative patients) which had shown positive results in COVID-19 infected patients were urine followed by serum (for aspergillus galactomannan). The candida isolation was seen in 27% (21/79) urine and 15%(12/79) respiratory samples (BAL, tracheal aspirate, sputum) in COVID-19 positive patients. Rhizopus arrhizus and Rhizopus homothallicus isolations were seen in nasal samples and tissue samples of 6% COVID-19 positive patients. There was an overall increase in fungal co-isolations during the COVID-19 pandemic (64% in COVID-19 positive and 43% in COVID-19 negative patients) which is a matter of great concern. The correlation of clinical symptomatology and laboratory isolation is important for the diagnosis and effective management of these patients.
A rare case of Na/Zn isomorphism in the crystal structure of non-centrosymmetric zincophosphate Na5Zn[Zn(PO4)3]
Authors: Yakubovich Olga V. , Kiriukhina Galina V. , Volkov Anatoly S. , Dimitrova Olga V. 
Published: December 2024

A microporous zincophosphate with the idealized formula Na5Zn[Zn(PO4)3] was obtained through high-temperature hydrothermal synthesis and characterized by scanning electron microscopy, microprobe analysis and X-ray diffraction. The orthorhombic compound, which crystallizes in non-centrosymmetric space group Pna21 with unit-cell parameters a = 12.9901 (2), b = 16.2647 (3), c = 5.2158 (1) Å and Z = 4, is characterized by a new structure type. Each ZnO4 tetrahedron shares all O atoms with four phosphate tetrahedra to form groups of five polyhedra, that are further linked via oxygen-bridging contacts of Zn- and P-centered tetrahedra in chains aligned in the c-axis direction. These one-periodic structural fragments [Zn(PO4)3]7− define the prismatic habitus of the crystals. The negatively charged zincophosphate chains are balanced by Na+ cations, disposed in an open space between the chains, and somewhat `diluted' with Zn2+, Ca2+ and Mn2+ ions as impurities. A rare case of the Na/Zn occupation of one structural site was found in the structure. Theoretical calculations of possible pathways of alkali metal ion migration through the structure and activation energies revealed that the Li-substituted counterpart Li5Zn[Zn(PO4)3] can be considered as a potential solid electrolyte.
Establishment of an end-user engaged building design framework
Authors: Nazeer Fathima Sabrina , Kamardeen Imriyas , Hasan Abid 
Published: December 2024

PurposeSignificant gaps between end-user expectations and the actual performance of buildings have been reported. Engaging end-users in the design phase is proposed to address this issue; however, practical implementation faces numerous challenges due to limited details of methods, tools and techniques for effective user engagement. This study aims to critically analyse the challenges in end-user engagement in the design process, thereby proposing a new, enhanced framework for end-user engaged building design.Design/methodology/approachA systematic literature review was conducted, involving a comprehensive search across Scopus, ScienceDirect, Web of Science and Google Scholar, yielding 481 articles. After eliminating duplicates and irrelevant studies, this pool was narrowed down to 31. Meta-synthesis of the existing body of knowledge and its extrapolation were performed.FindingsThree design approaches – participatory, user-centred and co-design exist to facilitate user engagement during the design process, aiming to mitigate performance gaps. However, they encounter significant challenges, including a lack of standardised processes for identifying the right users, acquiring and reconciling end-user requirements and evaluating designs. A new framework for enhanced end-user engagement in the design phase is proposed to address these challenges.Originality/valueThe proposed framework would enhance user engagement in building design, consequently mitigating performance gaps and bolstering occupant productivity and satisfaction. Additionally, the study identifies the challenges associated with the user-engagement process and consolidating user feedback, which is often vague and ambiguous by nature. Addressing these challenges is identified as future research needs to yield better outcomes from end-user engagement.
Sensory expectations of beverages generated by colours: a cross-cultural comparison among young consumers
Authors: Campo Raffaele , Porcheddu Daniele , Rosato Pierfelice , Mai Lan Thanh 
Published: December 2024

PurposeThis research is aimed at exploring how colours impact the taste expectations of beverages, considering three different countries: Italy, Poland and Morocco. Specifically, the purpose is to analyse how the sensory interaction can affect young consumers and if the cultural aspect affects them in order to draw consumer behaviour implications.Design/methodology/approachThis is cross-cultural research, structured into two studies. Researchers have administered two questionnaires for each study. Both the questionnaires included 12 questions (three colours – that were red, yellow and orange – × four flavours – that were sweetness, sourness, bitterness and saltiness): participants were asked to express an evaluation on a scale of 1–10 regarding the association between a certain colour of a hypothetical drink and a certain taste. About 150 subjects were involved: 50 Italians, 50 Poles and 50 Moroccans.FindingsResults highlighted differences between these three national groups. In particular, yellow generated more bitter/salty expectation by Italians (vs Poles) while Poles perceived the red beverage as sweeter and the orange one sourer than Italians. Moreover, yellow and orange beverages inspired sour expectations in Moroccans, compared to Italians.Originality/valueThe comparison between Italy, Poland and Morocco is the most original aspect of this study. Cross-cultural studies are spread in cross-modal research, but this combination is new in literature. In addition, the focus on young consumers and on online environments are further elements of originality.
Understanding the effect of anthropomorphic features of humanoid social robots on user satisfaction: a stimulus-organism-response approach
Authors: Premathilake Gehan Wishwajith , Li Hongxiu , Li Chenglong , Liu Yong , Han Shengnan 
Published: December 2024

PurposeHumanoid social robots (HSRs) are an innovative technology revitalizing various service sectors, such as the hospitality industry. However, limited research has explored how anthropomorphic features of HSRs influence user satisfaction with the services delivered by HSRs. To address this, a research model was proposed to evaluate how three distinct anthropomorphic features: appearance, voice and response, impact the perceived values (i.e. utilitarian, social and hedonic values) of HSRs, which, in turn, influence user satisfaction.Design/methodology/approachData from an online survey of hotel customers was utilized to test the research model (N = 509).FindingsThe results indicated that appearance, voice, and response affect perceived utilitarian, hedonic and social values differently. The response feature of HSRs demonstrated the strongest impact on perceived utilitarian, social and hedonic values. In addition, voice affected all three perceived values, while appearance only affected perceived utilitarian and social values. Furthermore, perceived utilitarian, hedonic and social values showed positive impacts on user satisfaction, with hedonic value being the most influential factor.Originality/valueThis study contributes to the literature on HSRs and anthropomorphism by explaining how different anthropomorphic features affect users’ value perceptions and user satisfaction with HSR services by utilizing the stimulus-organism-response (SOR) framework.
Trends in pharmaceutical marketing and branding research: a bibliometric analysis (2009–2023)
Authors: Anthuvan Thamburaj , Maheshwari Kajal , Dantu Raghunath 
Published: December 2024

PurposeThis study conducts a comprehensive bibliometric analysis of pharmaceutical marketing and branding research, focusing on the transformative period of the last 15 years (2009–2023), particularly during and after the COVID-19 pandemic. The purpose of this analysis is to highlight key shifts and trends in the field over this period.Design/methodology/approachThis study examined 329 research papers sourced from JSTOR and PubMed. It explores the evolution of the field, emphasizing significant shifts and trends.FindingsThe analysis identified 2009 and 2014 as pivotal years for research activity, with The British Medical Journal and BioMed Central emerging as key publication platforms. Contributions from the USA, led by authors like Joel Lexchin, were particularly notable. The study also highlighted a shift toward AI-driven marketing, digital transformation and personalized medicine, especially in the post-COVID-19 period (2020 onwards). Co-authorship networks and keyword analysis emphasized the growing focus on regulatory compliance, patient engagement and the integration of digital tools in pharmaceutical marketing.Originality/valueThis study charts the historical and current state of pharmaceutical marketing and branding and sets the foundation for future research, emphasizing the increasing role of digitalization and AI.
Transformations in the Chinese capital market: technological innovations, sustainability and regulatory reforms (1999–2023)
Authors: Han Jianlei , Jones Stewart , Liang Zini , Pan Zheyao , Shi Jing 
Published: December 2024

PurposeThis paper examines the evolving landscape of accounting and finance research on the Chinese capital market, building on a previous study published at Abacus in 2018.Design/methodology/approachBy incorporating data from 1999 to 2023, our analysis offers a detailed examination of shifts in academic focus, methodological advancements and thematic expansions over the last quarter-century.FindingsThe study reveals a substantial increase in accounting and finance publications related to the Chinese capital market in both Tier 1 and Asia-Pacific journals. The dynamic growth of the Chinese capital market during this period reflects profound economic transformations, characterized by technological innovations, sustainability commitments and regulatory reforms.Originality/valueWe conclude that the globally important Chinese capital market has attracted increasing academic attention, significantly advancing the understanding of accounting and finance research in China’s capital market.