bluuebunny/crossref_metadata_2025_split huggingface dataset:
14 Application of Selective Asymmetric Borylation to Target Compounds
Authors: Gong T.-J. , Ahmed E.-A. M. A. , Fu Y. 
Published: November 2019

AbstractThis chapter describes recent progress in the use of transition-metal-catalyzed asymmetric borylation (asymmetric hydroboration, diboration, and borylative difunctionalization) for the preparation of enantioenriched chiral boronate ester derivatives, and for the synthesis of α- and β-aminoboronates. Moreover, selected applications of these asymmetric borylation protocols to the synthesis of biologically active compounds and natural products are presented.
Social behavior for autonomous vehicles
Authors: Schwarting Wilko , Pierson Alyssa , Alonso-Mora Javier , Karaman Sertac , Rus Daniela 
Published: November 2019

SignificanceWe present a framework that integrates social psychology tools into controller design for autonomous vehicles. Our key insight utilizes Social Value Orientation (SVO), quantifying an agent’s degree of selfishness or altruism, which allows us to better predict driver behavior. We model interactions between human and autonomous agents with game theory and the principle of best response. Our unified algorithm estimates driver SVOs and incorporates their predicted trajectories into the autonomous vehicle’s control while respecting safety constraints. We study common-yet-difficult traffic scenarios: highway merging and unprotected left turns. Incorporating SVO reduces error in predictions by 25%, validated on 92 human driving merges. Furthermore, we find that merging drivers are more competitive than nonmerging drivers.
Resolving titin’s lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes
Authors: Rudolph Franziska , Hüttemeister Judith , da Silva Lopes Katharina , Jüttner René , Yu Lily , Bergmann Nora , Friedrich Dhana , Preibisch Stephan , Wagner Eva , Lehnart Stephan E. , Gregorio Carol C. , Gotthardt Michael 
Published: November 2019

Significance
Building and maintaining sarcomeres is a tremendous challenge for the myocyte. This includes expression of the giant protein titin, assembly of the premyofibril, integration of titin into the sarcomere lattice, and remodeling under load with elimination of aged sarcomeric proteins. It is still unclear how titin synthesis and sarcomere assembly are orchestrated, how titin is integrated into the sarcomere, and how working sarcomeres afford constant remodeling, as they need to exchange titin proteins at the end of their lifetime. Here, we use a dual fluorophore knockin mouse that allows us to simultaneously follow titin’s N and C termini in vivo and study titin integration into the developing and mature sarcomere as well as sarcomere remodeling and disassembly.
Chromosome disentanglement driven via optimal compaction of loop-extruded brush structures
Authors: Brahmachari Sumitabha , Marko John F. 
Published: November 2019

Significance
Topology simplification of chromosomes occurs simultaneously with their segregation during cell division and is driven by interplay between chromosome compaction and topology fluctuations. Loop extrusion, a mechanism of genome organization where DNA/chromatin loops are actively extruded to form a cylindrical polymer “brush,” has been proposed as a mechanism underlying chromosome folding and compaction. In this study, we show that such a brush model possesses an optimal loop size that simultaneously maximizes lengthwise compaction and minimizes interchromosomal entanglement. Our model predicts the optimal loop size and other experimentally observable properties of chromosomes for a wide range of organisms of varied genome size.
Single-molecule imaging of HIV-1 envelope glycoprotein dynamics and Gag lattice association exposes determinants responsible for virus incorporation
Authors: Pezeshkian Nairi , Groves Nicholas S. , van Engelenburg Schuyler B. 
Published: November 2019

Significance
To create an infectious HIV-1 particle, the envelope glycoprotein (Env) must find a budding virus assembly site on the surface of an infected cell. Assembly sites are composed of growing 2-dimensional lattices of the structural Gag protein anchored to the plasma membrane by the matrix domain. The cytoplasmic tail of Env and the matrix domain are physically proximal on the inner leaflet of the membrane, placing these elements in direct contact upon encounter. We provide single-molecule evidence that the Env cytoplasmic tail and a single residue in matrix are necessary for lattice retention of Env, with membrane budding being dispensable. This supports a model for direct interaction or corralling of Env by the matrix domain and suggests that a druggable interface exists.
Arousal regulates frequency tuning in primary auditory cortex
Authors: Lin Pei-Ann , Asinof Samuel K. , Edwards Nicholas J. , Isaacson Jeffry S. 
Published: November 2019

Significance
Changes in brain state modulate how information is processed in sensory cortical areas. Here we use population imaging and intracellular recording to show that arousal regulates frequency tuning in layer 2/3 of primary auditory cortex. Increased arousal reduces lateral inhibition, broadens frequency tuning and enhances cortical representations of pure tones. Despite the arousal-dependent reduction in stimulus selectivity, frequency discrimination by cell ensembles improves due to a reduction in correlated variability (noise correlations).
Extensive free-energy simulations identify water as the base in nucleotide addition by DNA polymerase
Authors: Roston Daniel , Demapan Darren , Cui Qiang 
Published: November 2019

Significance
The microscopic chemical mechanism of adding a base to a growing strand of DNA during DNA replication is unknown. The chemistry requires multiple proton transfers in a complex active site, and experimental probes have been unable to distinguish among the many plausible reaction pathways. This work uses an efficient computational approach to systematically survey the many plausible chemical mechanisms for the reaction and concludes that a water molecule in the active site plays a crucial role. The work also clarifies the catalytic role played by a controversial third metal cation that appeared in the active site during crystallographic studies. The new mechanistic understanding will guide studies of medically and technologically vital questions on DNA replication, gene expression, and gene editing.
Identification of Reg3β-producing cells using IL-22-stimulated enteroids
Authors: Sato Mika , Inaba Akihiko , Iwatsuki Ken , Saito Yuki , Tadaishi Miki , Shimizu Makoto , Kobayashi-Hattori Kazuo 
Published: November 2019

ABSTRACT
Reg3β, a lectin, displays antibacterial activity. This study investigated Reg3β-expressing cells using IL-22-stimulated enteroids. IL-22 stimulation elevated the mRNA and protein levels of Reg3β. IL-22 also increased the mRNA levels of CD133 (a transit-amplifying cell marker) and lysozyme (a Paneth cell marker). Immunohistochemistry showed partial colocalization of Reg3β- and lysozyme-positive cells, suggesting that Paneth cells are one of Reg3β-producing cells.
Audiological and psychological profiles of children with tinnitus
Authors: Raj-Koziak Danuta , Bieńkowska Katarzyna , Gos Elżbieta , Włodarczyk Elżbieta , Skarżyński Henryk , Skarżyński Piotr Henryk 
Published: November 2019

Purpose:
The objective of the study was to gauge the audiological and psychological profiles of children with tinnitus.

Method:
We recruited 25 paediatric patients (aged less than 18 years) reporting tinnitus who voluntarily came to our clinic in 2017. The children and their parents underwent a structured interview as part of a consultation in the Tinnitus Department. Otolaryngological examination and tonal and impedance audiometry were performed. Children filled in a Visual Analogue Scale (VAS) on loudness, annoyance, and how well they were coping with their tinnitus. Additionally, we used the Revised Children's Anxiety and Depression Scale and the Revised Children Anxiety and Depression Scale (Parent Version) to look for possible depressive and anxiety disorders, and the EAS Temperament Survey to assess the temperament of the children.

Results:
The group consisted of 25 children (16 girls and 9 boys) aged from 6 to 16 years. Most of the children had normal hearing. Tinnitus had a significant daily impact on sleeping, studying, and leisure. The VAS scale results revealed that younger children, 6 to 10 years old, found tinnitus more troublesome than older children (11 to 16 years). No child with tinnitus showed any severe symptoms of depression or anxiety. All showed average levels of temperamental traits, close to normative values.

Conclusion:
When diagnosing tinnitus in children it is important to recognize that tinnitus affects children differently to adults. Whether children with tinnitus require specific intervention remains a difficult question to answer. Hence, there is an urgent need to devise a questionnaire that can assess the impact of tinnitus on children’s quality of life.
The use Instagram with visiting interest: The correlation between the use @littlecollins.bdg Instagram with visiting interest
Authors: Ahmadi D , Adzhani A V 
Published: November 2019

Abstract
In this research the aim was to determine how far of the influence of using social media Instagram with visiting interest. As done by one Instagram of one of the new restaurants in Bandung that is Cafe Little Collins and have Instagram that is @littlecollins.bdg. In this research, researchers used a quantitative approach and using correlational studies. The results indicate the correlation between the use of Instagram with visiting followers’ interest is a significant correlation. Because the data collection technique used was a questionnaire with 95 respondents and a literature study relevant for this research. After the data collected then performed analysis and hypothesis test using Spearman Rho ranks correlation.
Utilization of information technology for sustainable rural development
Authors: Chaerowati D L , Ibrahim I S 
Published: November 2019

Abstract
This paper presents the utilization of information and communication technology in a rural community in Indonesia, which experiences a development gap caused by structural constraints and lack of infrastructure. The paper based on field research by taking the case of a village called Mandalamekar in Tasikmalaya, West Java, which uses information technology as a tool of struggle for rural development. This study refers to the concept of sustainable rural development using case study research with data collection techniques in the forms of interviews, observation, and document studies. This paper discusses the society of using information technology and the variety of ITs applied in the rural development. Since the rural community took advantage of information technology, the acceleration of transformation took place on ability to build and operate the technology and media as its main tool. This paper proves that IT can be effective tools for sustainable rural development. IT not only influences how people interacts each other, but at the same time, it affects how people find mutual solutions for rural problems.
A preliminary study of bit-integer hash function for bilinear pairing identity-based cryptosystem
Authors: Saputra D E 
Published: November 2019

Abstract
Hash function is a crucial part of identity-based cryptosystem, especially for identity-based cryptosystem that utilize bilinear pairing as its core mechanism. However, the hash function has specific requirement that most of commonly known function are not suitable for this purpose, especially the requirement that requires the output length of function is varies. A variable length hash function, such as HAVAL, only provide multiple option for its output length. While the identity-based cryptosystem require that the length of the output can be any number. This study aims to create a hash function to fulfil the identity-based cryptosystem requirement. This study modifies the MD5 hashing algorithm to produce a variable length output, which called the Bit-Integer hash function. The result shows a proof-of-concept that Merkle-Damgård construction can be used to create a variable length hash function. The hash value of Bit-Integer hash function can produce random-like result which is essential for any cryptographic hash function.
A competing risks regression model based on the exponential Gompertz-like subdistribution
Authors: Kudus A , Suliadi S , Herlina M 
Published: November 2019

AbstractIn some situations, research activities are conducted to measure the length of time until the event occurred. If it is possible to have not only the event of interest but also the competing events, then it is a kind of competing risks data. The main parameter of interest is the subdistribution function that shows the percentage of failing individuals due to a cause of interest. If the subdistribution needs to be predicted by predictor variables, then the regression model for competing risks data should be developed. In this paper, the regression model for the exponential Gompertz-like subdistribution is proposed. We use maximum likelihood estimation method to estimate the model parameters. Specifically, the subdistribution of the main event and all the rest competing events are estimated simultaneously. The proposed model was applied to the data of contraceptive discontinuation and gave a good result. Goodness-of-fit of the estimated regression model measured by the likelihood and Akaike Information Criterion (AIC) also gave the acceptable values.
Context integration GIS of education relevant in secondary school TVET
Authors: Bakri A , Sugiarti Y , Wahyudin D 
Published: November 2019

AbstractAn initiative approach that focuses on software for the integration of GIS technology in the secondary school curriculum is the same, regardless of whether one teaches technical secondary school science, social secondary school, or basic art. While demonstration of sample resources and project approaches, technology-based education reforms, structured / standardized professional development workshops or courses, and teacher education programs that focus on technology are different because students need to learn GIS technology using learning materials tailored to their needs and situations. unique. The 'Learn about GIS' approach for TVET secondary school students is an effective way to operate software, with supporting instructions in cartography, database design, and programming. Learning to think of the world through the mediation perspective provided by technology can influence geospatial thinking and its development. The researcher notes that individual teacher support, local data usage, local problem scenarios, and administrative commitment, are critical issues for the development of professional GIS in TVET Middle School. Reforming the science and technology curriculum involving the acceptance of GIS in learning requires continuous professional development, related to the implementation of the GIS curriculum. Therefore, it is important to investigate the skills needed to improve the workability of TVET secondary schools in the Geomatics and Geospatial Engineering department.
Literature study on the theory of GIS-based multi evaluation criteria
Authors: Widianingsih I , Masri R M , Abdullah A G 
Published: November 2019

Abstract
Multi-criteria evaluation method is a method that can be used in making decisions by making complex issues into simple. GIS (Geographic Information System) is a tool that has a positive impact in the scientific decision-making process of planning for program development activities. Decision-making by integrating the multi-criteria evaluation with GIS has significant potential for the complexity of making a decision. The study of literature of this article focuses on the discussion of multi-criteria evaluation based on GIS. The purpose of writing this article is to organize and classify articles decisions using GIS-based MCDA. Based on the results of the study, determining the location of the housing using GIS-based multicriteria evaluation became the topic most widely presented. GIS-based multicriteria evaluation gave the result of decisions capable of precise, fast and effective.
Augmented reality based on stem for supporting science literacy in vocational education
Authors: Agustina W W , Sumarto S , Trisno B 
Published: November 2019

Abstract
AR development is becoming very popular in various fields of science. Some researchers have demonstrated that AR has the potential in science, technology, engineering, and mathematics (STEM). Puse of total AR integrated STEM needs to be studied more deeply, how STEM-AR characteristics, and how the potential of AR-based STEM to support the scientific literacy of students. Searches through relevant sources, the online database of which seven ACM Digital Library, ERIC, ieeexplore, ISI Web of Science, ScienceDirect, Scopus, and Springer. The results showed that the use of STEM-AR potentially an effort to improve science literacy.
The effectiveness of short message service advertising using EPIC model on consumer perception and purchase intention
Authors: Oktafani F , Suryawardani B 
Published: November 2019

Abstract
This study was aimed to find out the effectiveness of Telkomsel SMS advertising using EPIC Model, and to find out the influence of SMS advertising to perception and purchasing interest partially and simultaneously. The method used was descriptive verification with purposive sampling technique. Then the data was analyzed using path analysis. The results showed that the effectiveness of Telkomsel SMS advertising using EPIC model has 3.58 EPIC rate. Meanwhile, the influence of SMS advertising to customer perception was 40.6%, customer perception to purchasing interest was 25.6%, and SMS advertising to purchasing interest of Telkomsel sim card users was 19.4%.
Self-control and online game addiction in early adult gamers
Authors: Safarina N , Halimah L 
Published: November 2019

Abstract
Early adulthood is a productive period in development stage which involves more complex experiences and responsibilities. Contrary to what early adulthood should do, it was found that there were individuals who spent almost all their time playing online games at internet cafes. They always visit cyber cafes and usually play online games for at least 10 hours every day, which usually leads to various problem. This study aimed to see the correlation of self-control and online game addiction in early adult gamers. A total of 33 online gamers in early adulthood stage participated in this study and were asked to complete self-report measures using questionnaires. Questionnaires included demographic information, Brief Self-control Scale constructed by Tangney, et al. and Game Addiction Scale constructed by Lemmens, et al. Rank Spearman correlation was used to analyze the data and the result indicated that there are two aspects of self-control that have significant correlation with online game addiction (Deliberate/Non-impulsive and Self-discipline) and the other three aspects of self-control have insignificant correlation with online game addiction (Healthy Habit, Work Ethic, and Reliability). The overall result shows that self-control is significantly negative correlated with online game addiction. This means the lower the self-control, the more severe the probability of suffering online game addiction in early adult gamers.
20 years of INT KIT-USATU collaboration in the area of SPD
Authors: Hahn H , Ivanisenko Y , Kilmametov A 
Published: November 2019

Abstract
The field of Severe Plastic Deformation (SPD) has provided the scientific community with ultrafine grained and nanocrystalline materials. In contrast to other techniques for the synthesis of nanostructured materials, SPD processes allow the preparation of bulk quantities of metals and alloys. Technical applications have become a reality because commercial alloys can be transformed into novel nano- and microstructures, leading to superior mechanical properties, such as high strength and high ductility, resulting in many application areas. The field was pioneered at the Ufa State Aviation Technical University and has created worldwide interest. The report emphasizes some results of the close collaboration between Ufa State Aviation Technical University and the Institute of Nanotechnology at Karlsruhe Institute of Technology (KIT).
Surface modification of CP-Ti metallic implant material by plasma electrolytic oxidation
Authors: Rameshbabu N , Ravisankar B , Saikiran A , Parfenov E V , Valiev R Z 
Published: November 2019

Abstract
Plasma electrolytic oxidation (PEO) is a relatively new and environmentally friendly process for development of thick and adherent oxide coatings on conventional and nanostructured metallic implant materials. The PEO process involves anodic oxidation of metals or alloys in aqueous solutions at voltages higher than the breakdown voltage of the oxides present on its surfaces. Currently, the PEO process is gaining increased attention as a novel technique for the fabrication of corrosion resistant, bioactive and functionally modulated composite coatings on commercial pure titanium (Cp-Ti) and Ti based alloys for orthopedic and dental applications. The PEO process coupled with the electrophoretic deposition (EPD) technique is used for the fabrication of TiO2/hydroxyapatite (HA) composite coating on a Cp-Ti implant material in a single step. This paper briefly reviews the properties of the coatings produced on Cp-Ti by PEO and PEO coupled EPD processes.
Deformation and current interaction in nanostructured and amorphous Ti based alloys
Authors: Stolyarov V V 
Published: November 2019

Abstract
The deformation behavior under tension and pulse current in course-grained, nanostructured and amorphous titanium based alloys is investigated. The influence of grain size, structure state and current mode on shape memory effect and electroplastic effect has been shown. Structure refinement up to nanosize area, occurrence of interphase boundaries, and amorphous state in alloys suppress the electroplastic effect. In TiNi alloys with phase thermoelastic transformation induced by deformation or temperature, current pulses decreases stress jumps downwards induced by manifestation of the electroplastic effect and increases stress jumps upwards connected with the shape memory effect.
Structural features and mechanical properties of Grade 4 titanium from VSMPO-AVISMA (Russia) and Grade 4 titanium from Carpenter Technology Corporation (USA), subjected to ECAP-Conform
Authors: Kodirov I S , Valiev R Z , Raab G I , Aleshin G N , Raab A G 
Published: November 2019

Abstract
In this paper, we analyze the microstructural features and mechanical properties of the Grade 4 titanium produced in Russia (VSMPO-AVISMA) and Grade 4 titanium from Carpenter Technology Corporation (USA). It is shown that during the ECAP-Conform processing and subsequent drawing, a homogeneous UFG structure is formed in both Ti materials, providing an enhanced level of mechanical properties with an ultimate tensile strength σB > 1200 MPa and an elongation to failure δ ~ 12%.