bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of tumours and tumour like lesions in the Eye and its Adnexa: Our experience of 80 cases with review of literature
Authors: R Sonwane Bharat , J Nandkar Somnath 
Published: April 2020

The eye is a unique special sensory organ which exhibits diverse histologic structures. Clinical signs symptoms of ocular malignancies simulate more commonly occurring benign conditions which pose great difficulties both for treating clinicians even experienced pathologists. The present study is to evaluate the histomorphological spectrum of lesions of entire eyeball and ocular adnexa to compare our results with other studies.The present study included the 80 cases of tumours tumour like lesions in the eye its adnexa, in our institute during June 2013 to October 2015. All biopsies were embedded completely after thorough gross examination, resected specimens were noted for size, shape, consistency approximate section were taken. The enucleated eyeballs are sectioned according to stard protocols.In the present study, 80 cases of tumours and tumour like lesions in the eye its adnexa was carried. Out of these, eye lid was affected in 43 cases (53.75%), conjunctival cornea in16 cases (20%), intraocular in 17 cases (21.25%) orbit in 4 cases (05%).Among 80 cases maximum 44 cases (55%) were of malignant tumours followed by tumour like lesions 24 cases (30%) 12 cases (15%) of benign tumours. Histopathological examinations of orbital ocular lesions are absolutely mandatory for definitive diagnosis and further management. Illiterate patient take some home remedies, which leads to complications and loss of eyesight. So awareness is needed to ensure early presentation.
Comparitive study of effectiveness of external dacryocystorhinostomy with silicone tube placement versus silicone tube with application of Mitomycin–C in nasolacrimal duct obstruction
Authors: Verma Neha , Kumar Ram 
Published: April 2020

: To compare the effectiveness ofexternal dacryocystorhinostomy(DCR) with Silicone tube(SI) placement versus Silicone tube with application of Mitomycin–C(MMC) in Nasolacrimal Duct Obstruction(NLDO).: The study was conducted in the department of Ophthalmology, at BRD medical college, Gorakhpur, U.P., India between March 2018 to June 2019.It was a prospective randomized study, where we studied 88 eyes from patients who presented with simple epiphora due to primary acquired NLDO. The patients were randomly assigned into two groups, where one group was subjected to external DCR along with the placement of a silicone tube ,and the other group underwent silicone tube placement followed by the application of 0.2mg/ml of anti-metabolite MMC.After a 6 month follow-up, it was noted that there was no statistically significant difference between the two groups, i.e., when considering patients with simple epiphora secondary to primary acquired NLDO, external DCR with silicone tube and silicone tube with MMC(0.2mg/ml) application are at par with each other in terms of effectiveness. However, silicone intubation with MMC is a minimally invasive procedure when compared to external DCR with silicone tube placement.
Estudio genético en embarazadas
Authors: Posso Álvarez Julio César , Sinisterra Galarza Sandra Liliana , Vásquez Zapata Gustavo Adolfo , Isaza de Lourido Carolina 
Published: April 2020

Introducción: con base en el impacto que genera el hallazgo de un feto o recién nacido con alguna alteración cromosómica, desde el punto de vista familiar, social y para las entidades de salud, se analizan los resultados de los estudios genéticos realizados por el Servicio de Perinatología de la Clínica Rafael Uribe Uribe del Instituto de los Seguros Sociales en la ciudad de Cali, durante los últimos seis años.Objetivo: describir la frecuencia de las alteraciones cromosómicas encontradas en la Clínica Rafael Uribe Uribe de Cali durante los estudios genéticos realizados por el Servicio de Perinatología de este centro desde enero 1 de 1997 hasta diciembre 31 de 2002.Materiales y métodos: se realizó un estudio retrospectivo, en el cual se revisaron las historias clínicas de todos los procedimientos genéticos practicados a las gestantes que aceptaron amniocentesis o cordocentesis según la indicación.Resultados: se encontraron 615 procedimientos de diagnóstico prenatal: 604 amniocentesis (98,21%) y 11 cordocentesis (1,79%). Se evidenciaron 19 estudios anormales (3,09%); de ellos, 17 correspondieron a aneuploidias (89,47%): seis trisomías 21 (31,57%), 4 trisomías 18 (21,05%), dos trisomías 13 (10,52%), dos síndromes de Klinefelter (10,52%) y tres monosomías 45XO (15,78%); se presentaron dos alteraciones estructurales (10,53), de las cuales una correspondió a una translocación reciproca (46XX, t (6,15) der 15) (5,26%) y una delección (46XX, 9 q (-)) (5,26%).Las indicaciones más frecuentes del estudio genético fueron:Edad materna (>35 años).Hallazgos ecográficos.Deseo de la pareja.Conclusiones: los resultados obtenidos no distan de los publicados en la literatura mundial; la alteración cromosómica más frecuente fue la trisomía 21. Puesto que para diagnosticar una alteración cromosómica se requirieron 32 estudios de diagnóstico prenatal, debemos afinar (con la ayuda de las directivas de la institución) en la determinación de marcadores ecográficos y bioquímicos con el propósito de someter al menor número de pacientes al riesgo que implican los procedimientos invasivos.
Comparison of The Effects of Remifentanil and Fentanyl Combined with Desflurane on Intraoperative Hemodynamic Parameters and Postoperative Recovery Period in Anesthesia for Day Case Surgery
Authors: DOĞAN Murat , GÜNGÖRDÜ Ezgi 
Published: April 2020

Objective: We aimed to compare the effects of two different opioids, fentanyl and remifentanil with short-acting inhalation agent, desflurane on intraoperative hemodynamics and recovery quality in the postoperative period in anesthesia for day case surgery.Methods: A prospective randomized case control study was carried out at Anesthesia and Reanimation Clinics of The Istanbul Education and Research Hospital with the approval of the local ethics committee between 2001-2002. The study population (n=100) who has arthroscopic knee surgery was composed of patients between the ages of 18-65 classified as ASAI-II. The cases were randomized and divided into two groups. After giving fentanyl to patients in the first group and remifentanil infusion to patients in the second group, induction has administered by propofol and mivacurium was given as a muscle relaxant in both groups. After endotracheal intubation, systemic blood pressure, heart rate and peripheral oxygen saturation (SpO2) values were recorded every five minutes. When the surgery was completed, eye opening, following commands, saying her name, saying her birthday, sitting without help and getting the correct answer to the DSS test was recorded for both groups. Visual Pain Scale (VAS) and Modified Aldrete Score were evaluated and recorded at 0, 15, 30, and 60 minutes. Patients were observed and recorded in terms of side effects such as increased secretion, bradycardia, nausea, vomiting, dizziness, headache, and tremors in both groups.Results : In terms of demographic features there was no statistically significant difference between the two groups. Generally; systemic blood pressures were significantly higher in the fentanyl group. Heart rate was significantly higher in fentanyl group during intubation and intraoperative periods . There was no statistically significant difference between groups in terms of Sp02 . Time until spontaneous breathing, extubation, eye opening, following commands, saying the name, DSST and unassisted sitting were significantly longer in the fentanyl group . The mean values of VAS scores at the 15th and 30th minutes were significantly higher in the remifentanil group . Similarly, the mean Aldrete recovery scale score scores at 15th and 30th minutes were significantly higher in the remifentanil group . When postoperative pathological findings were evaluated, the frequency of bradycardia was significantly higher in the remifentanil group, there was no difference in terms of other side effects. Conclusion: According to the our study results; we concluded that it is a better alternative to use remifentanil together with desflurane which is preferred short-acting inhalation agent in ambulatory anesthesia; in terms of hemodynamic stability during the intubation, peroperative and extubation periods and rapid postoperative recovery.
Robust Algorithms for History Matching of Imperfect Subsurface Models
Authors: Rammay Muzammil H. , Elsheikh Ahmed H. , Chen Yan 
Published: April 2020

Summary
In this work, we evaluate different algorithms to account for model errors while estimating the model parameters, especially when the model discrepancy (used interchangeably with “model error”) is large. In addition, we introduce two new algorithms that are closely related to some of the published approaches under consideration. Considering all these algorithms, the first calibration approach (base case scenario) relies on Bayesian inversion using iterative ensemble smoothing with annealing schedules without any special treatment for the model error. In the second approach, the residual obtained after calibration is used to iteratively update the total error covariance combining the effects of both model errors and measurement errors. In the third approach, the principal component analysis (PCA)-based error model is used to represent the model discrepancy during history matching. This leads to a joint inverse problem in which both the model parameters and the parameters of a PCA-based error model are estimated. For the joint inversion within the Bayesian framework, prior distributions have to be defined for all the estimated parameters, and the prior distribution for the PCA-based error model parameters are generally hard to define. In this study, the prior statistics of the model discrepancy parameters are estimated using the outputs from pairs of high-fidelity and low-fidelity models generated from the prior realizations. The fourth approach is similar to the third approach; however, an additional covariance matrix of difference between a PCA-based error model and the corresponding actual realizations of prior error is added to the covariance matrix of the measurement error.
The first newly introduced algorithm (fifth approach) relies on building an orthonormal basis for the misfit component of the error model, which is obtained from a difference between the PCA-based error model and the corresponding actual realizations of the prior error. The misfit component of the error model is subtracted from the data residual (difference between observations and model outputs) to eliminate the incorrect relative contribution to the prediction from the physical model and the error model. In the second newly introduced algorithm (sixth approach), we use the PCA-based error model as a physically motivated bias correction term and an iterative update of the covariance matrix of the total error during history matching. All the algorithms are evaluated using three forecasting measures, and the results show that a good parameterization of the error model is needed to obtain a good estimate of physical model parameters and to provide better predictions. In this study, the last three approaches (i.e., fourth, fifth, sixth) outperform the other methods in terms of the quality of estimated model parameters and the prediction capability of the calibrated imperfect models.
Kidney Outcome in Primary Focal Segmental Glomerulosclerosis (FSGS) by Using a Predictive Model
Authors: Ossareh Shahrzad , Yahyaei Mansoureh , Asgari Mojgan , Afghahi Hanri 
Published: April 2020

Abstract
Background: Focal segmental glomerulosclerosis (FSGS) is one of the important causes of end stage kidney disease (ESKD). We evaluated the risk factors of progression of primary FSGS to chronic kidney disease (CKD) or ESKD with a predictive model including clinical and histological predictors.Methods: 201 patients with primary FSGS (59% male, mean age: 38±15 years), were studied. Time-dependent Cox model and C statistics were used for the predictive model. Interaction and correlation between independent variables were estimated.Results: During 55±27 months of follow-up, 82 patients (41%) developed CKD (46) or ESKD (36) patients. In adjusted model, 1 unit of higher serum creatinine (SCr) at baseline (HR:1.39, 95%CI: 1.15-1.70) and 1% increase in glomeruli with segmental glomerulosclerosis (SGS) (HR: 1.03, 95% CI: 1.02-1.04) or interstitial fibrosis/tubular atrophy (IF/TA) (HR: 1.03, 95% CI: 1.01-1.05) increased the risk of CKD/ESKD. In adjusted model, higher baseline proteinuria and collapsing variant were not associated with risk of CKD/ESKD. By adding SGS and IF/TA scores to baseline SCr in the model, discrimination by C statistics was 0.83 (95%CI: 0.77-0.90). Median renal survival was 3.1 years (95% CI: 2.2-4.1 years) in patients with highest risks score (baseline eGFR<25 ml/min/1.73 m2+ IF/TA/SGS> 50%), and 8.1 years (95% CI: 7.7-8.6 years).in those with lowest score (baseline eGFR>75 ml/min/1.73 m2+ IF/TA/SGS <5%).Conclusion: In primary FSGS, higher baseline SCr, increased SGS and IF/TA, but not baseline proteinuria and collapsing pathology, were the predictors for CKD/ESKD. These findings indicated the importance of timely detection and referral in prognosis of primary FSGS.
Hypertension and its determinant factors in a Brazilian male working population Hypertension in male workers
Authors: Donato Tamyres Araújo Andrade , Bezerra Vanessa Moraes , Silva Roberta Mendes Abreu , Oliveira Márcio Galvão Guimarães de , Andrade Amanda Cristina de Souza , Kochergin Clavdia Nicolaevna , Soares Daniela Arruda , Medeiros Danielle Souto de , Louzado José Andrade , Silva Kelle Oliveira , Cortes Matheus Lopes , Mistro Sóstenes , Amorim Welma Wildes Cunha Coelho 
Published: April 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
A Population-Based Survey to Assess the Association between Cannabis and Quality of Life among Colorectal Cancer Survivors
Authors: Calcaterra Susan , Burnett-Hartman Andrea N. , Powers J. David , Corley Douglas A , McMullen Carmit M , Pawloski Pamala A. , Feigelson Heather Spencer 
Published: April 2020

Abstract
Background: As more states legalize cannabis for medical and recreational use, people increasingly use cannabis to treat medical conditions and associated symptoms. The prevalence and utility of cannabis for cancer-related symptoms may be clarified by examining cannabis use among patients with a common cancer diagnosis. We aimed to determine the prevalence of cannabis use among colorectal cancer (CRC) survivors and its associations with quality of life (QoL) and cancer-related symptomatology.Methods: A cross-sectional survey of patient-reported QoL outcomes and behaviors, including cannabis use, was conducted within the Patient Outcomes To Advance Learning network’s (PORTAL) CRC Cohort. The cohort included a population-based sample of healthcare system members ≥ 18 years old diagnosed with adenocarcinoma of the colon or rectum from 2010 through 2016. We assessed the association between cannabis use and QoL using the European Organization for Research and Treatment of Cancer QLQ-C30 summary score.Results: Of the 1,784 respondents, 293 (16.4%) reported cannabis use following CRC diagnosis. Current tobacco smokers were more likely to use cannabis compared to former or never tobacco smokers (adjusted odds ratio [aOR] 2.71, 95% confidence interval [CI] 1.56 to 4.70). Greater alcohol use (> 4 drinks per month versus ≤ 4 drinks per month) was associated with cannabis use (aOR 2.17, 95% CI 1.65 to 2.85). There was an association between cannabis use and cancer stage at diagnosis, with stage 3 or 4 CRC patients more likely to use cannabis than stage 1 or 2 CRC patients (aOR 1.68, 95% CI 1.25 to 2.25). After adjusting for demographics, medical comorbidities, stage and site of CRC diagnosis, and prescription opioid use, people who used cannabis had significantly lower QoL than people who did not use cannabis (difference of -6.14, 95% CI -8.07 to -4.20). Conclusion: Among CRC survivors, cannabis use was relatively common, associated with more advanced stages of disease, associated with tobacco and alcohol use, and not associated with better QoL. Clinicians should inquire about cannabis use among their patients and provide evidence-based recommendations for cancer-related symptoms.
Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil
Authors: Suehiro Tamy Taianne , Damke Gabrielle Marconi Zago Ferreira , Damke Edilson , Ramos Paloma Luana Rodrigues de Azevedo , Silva Marcela de Andrade Pereira , Pelloso Sandra Marisa , Huh Warner K , Franco Ricardo Argemiro Fonseca , Silva Vânia Ramos Sela da , Scarinci Isabel Cristina , Consolaro Marcia Edilaine Lopes 
Published: April 2020

Abstract
Background: Despite the demonstrated role of human Papillomavirus (HPV) in the etiology of cervical cancer and the strong evidence suggesting the importance of HPV in the development of oropharyngeal cancer, several aspects of the interrelationship between HPV infection in both body sites remain unknown, specifically in female human immunodeficiency virus (HIV)-positive (HIV+) patients. We aimed to assess the prevalence, distribution, and concordance of cervical and oral HPV in HIV+ women and matched HIV-negative (HIV-) controls in Brazil.Material and methods: Cervical and endocervical samples for cytological screening and HPV detection and oral samples were collected from 115 HIV+ women using highly active antiretroviral therapy (HAART) and 139 HIV-matched controls (HIV-) in Maringá City, Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding HIV infection were obtained from the patients’ medical records. HPV detection and typing were performed using the Kit Multiplex XGEN Multi HPV Chip HS12.Results: HIV infection was well controlled in this cohort, but women who exhibited detectable HIV loads were significantly associated with HPV-positive status overall (P = 0.03) and in cervical mucosa (P = 0.01). HIV+ women had significantly more abnormal cytological findings (P = 0.04) than HIV- women. Of the 115 HIV+ women, 48.7% were positive for cervical and/or oral HPV DNA; of the 139 HIV- women, 41% were positive for cervical and/or oral HPV (P = 0.25). Both HIV+ and HIV- women had a statistically higher prevalence of cervical HPV infection than oral infection. The concurrent HPV infection in two anatomical sites was similar in HIV+ and HIV- women; however, HPV type concordance was not observed. HPV type distribution was different between the anatomical sites in both groups, and HIV+ women presented less common types, mainly in oral mucosa.Conclusion: Our data support the importance of testing HPV infection in HIV+ women, even when the HIV infection is well controlled. Prospective studies are required to better understand the natural history of HPV infection in both anatomical sites, specifically in HIV+ women.
Individualized treatment for acute Achilles tendon rupture based on the Copenhagen Achilles Rupture Treatment Algorithm (CARTA): a study protocol for a multicenter randomized controlled trial
Authors: Hansen Maria Swennergren , Vestermark Marianne Toft , Hölmich Per , Kristensen Morten Tange , Barfod Kristoffer Weisskirchner 
Published: April 2020

Abstract
Background: An individualized treatment algorithm (Copenhagen Achilles Rupture Treatment Algorithm - CARTA) based on the ultrasonographic appearance of an acute Achilles tendon rupture has been developed aiming to select the correct patients for operative and non-operative treatment. The objective of this study is to investigate if this individualized treatment algorithm gives a better functional outcome than treating all patients either operatively or non-operatively per default. Methods: This study is conducted as a multicenter three-armed randomized controlled trial. Participants are included from four hospitals in Denmark and randomized 1:1:1 to one of three parallel groups: 1) Intervention group: Participants are treated according to an individualized treatment algorithm, 2) Control group A: Participants are treated non-operative, 3) Control group B: Participants are treated operative. The individualized treatment algorithm for the intervention group is based on an ultrasonographic examination; tendon overlap and elongation below 7% is to be treated non-operative, while no tendon overlap and and/or elongation above 7% will be treated operative. 300 participants will be included over a period of 3 years. The primary outcome is the heel-rise work test at 12 months post-injury. Secondary outcomes are tendon elongation, the Achilles tendon Total Rupture Score (ATRS), the rate of re-ruptures and other complications. The primary analysis will be conducted as intention-to-treat analysis.Discussion: This trial will indicate if treatment of acute Achilles tendon rupture can be individualized based on the elongation and tendon overlap. It is hypothesized that different patients will benefit from different treatment instead of offering all the same treatment. Trial registration: ClinicalTrials.gov Identifier: NCT03525964. Registered 16 May 2018.
Maternal Sciatic Nerve Administered Bupivacaine Induces Hippocampal Cell Apoptosis in Offspring
Authors: Mirkheshti Alireza , Shakeri Alireza , Memary Elham , Baniasadi Mansoureh , Zaringhalam Jalal , Tajbakhsh Ardeshir , Mirzaei Marzieh , Lak Elena 
Published: April 2020

Abstract
BackgroundBupivacaine, an amid-type local anesthetic, is widely used for clinical patients especially in pregnant women. In addition to neurotoxicity effect of bupivacaine, it can cross the placenta, accumulates in this tissue and retained in fetal tissues. Nevertheless, whether bupivacaine can cause neurotoxicity in fetus remains unclear. Hence, this study was design to investigate the effects of maternal bupivacaine use on fetus hippocampal cell apoptosis and the possible related mechanism.MethodsOn day 15 of pregnancy, sciatic nerve of pregnant wistar rat (180-200 g) were exposed by lateral incision of the right thigh and 0.2 ml of bupivacaine was injected. After their delivery, we randomly selected one male offspring of every mother. On day 30 after of their birth, the rat’s hippocampi were isolated for molecular studies. Western blotting was used to examine the expression of cleaved caspase-3, caspase-8 and p-Akt in fetal hippocampus.ResultsOur results showed that maternal bupivacaine use caused a significant increment of cleaved caspase-3 and caspase-8 expression in fetal hippocampus compared with the sham group. In addition, maternally administered bupivacaine could significantly decrease hippocampal P.Akt/T.Akt ratio which was concurrent with an increment of cleaved caspase-3 and caspase-8 expression.ConclusionOur data suggest that maternal bupivacaine use increases fetal hippocampal cell apoptosis markers such as caspase 8 and cleaved caspase 3, at least in part, via inhibiting the Akt activation.