bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease
Authors: Béchet Sibylle , O'Sullivan Sinead A. , Yssel Justin , Fagan Steven G. , Dev Kumlesh K. 
Published: March 2020

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-induced glial cell death and demyelination bothin vitroandex vivomodels. These data, together with a lack of therapies for Krabbe's disease, prompted the current preclinical study examining the effects of fingolimod in twitcher mice, a murine model of Krabbe's disease. Twitcher mice, both male and female, carrying a natural mutation in the galc gene were given fingolimod via drinking water (1 mg/kg/d). The direct impact of fingolimod administration was assessed via histochemical and biochemical analysis using markers of myelin, astrocytes, microglia, neurons, globoid cells, and immune cells. The effects of fingolimod on twitching behavior and life span were also demonstrated. Our results show that treatment of twitcher mice with fingolimod significantly rescued myelin levels compared with vehicle-treated animals and also regulated astrocyte and microglial reactivity. Furthermore, nonphosphorylated neurofilament levels were decreased, indicating neuroprotective and neurorestorative processes. These protective effects of fingolimod on twitcher mice brain pathology was reflected by an increased life span of fingolimod-treated twitcher mice. Thesein vivofindings corroborate initialin vitrostudies and highlight the potential use of S1P receptors as drug targets for treatment of Krabbe's disease.SIGNIFICANCE STATEMENTThis study demonstrates that the administration of the therapy known as fingolimod in a mouse model of Krabbe's disease (namely, the twitcher mouse model) significantly rescues myelin levels. Further, the drug fingolimod also regulates the reactivity of glial cells, astrocytes and microglia, in this mouse model. These protective effects of fingolimod result in an increased life span of twitcher mice.
18F-FDOPA PET/CT accurately identifies MEN1-associated pheochromocytoma
Authors: Tepede Aisha A , Welch James , Lee Maya , Mandl Adel , Agarwal Sunita K , Nilubol Naris , Patel Dhaval , Cochran Craig , Simonds William F , Weinstein Lee S , Jha Abhishek , Millo Corina , Pacak Karel , Blau Jenny E 
Published: March 2020

Summary
Pheochromocytoma (PHEO) in multiple endocrine neoplasia type 1 (MEN1) is extremely rare. The incidence is reported as less than 2%. We report a case of a 76-year-old male with familial MEN1 who was found to have unilateral PHEO. Although the patient was normotensive and asymptomatic, routine screening imaging with CT demonstrated bilateral adrenal masses. The left adrenal mass grew from 2.5 to 3.9 cm over 4 years with attenuation values of 9 Hounsfield units (HU) pre-contrast and 15 HU post-contrast washout. Laboratory evaluation demonstrated an adrenergic biochemical phenotype. Both 18F-fluorodeoxyglucose (18F-FDG) PET/CT and 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy demonstrated bilateral adrenal uptake. In contrast, 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET/CT demonstrated unilateral left adrenal uptake (28.7 standardized uptake value (SUV)) and physiologic right adrenal uptake. The patient underwent an uneventful left adrenalectomy with pathology consistent for PHEO. Post-operatively, he had biochemical normalization. A review of the literature suggests that adrenal tumors >2 cm may be at higher risk for pheochromocytoma in patients with MEN1. Despite a lack of symptoms related to catecholamine excess, enlarging adrenal nodules should be biochemically screened for PHEO. 18F-FDOPA PET/CT may be beneficial for localization in these patients.

Learning points:

18F-FDOPA PET/CT is a beneficial imaging modality for identifying pheochromocytoma in MEN1 patients.

Adrenal adenomas should undergo routine biochemical workup for PHEO in MEN1 and can have serious peri-operative complications if not recognized, given that MEN1 patients undergo frequent surgical interventions.

MEN1 is implicated in the tumorigenesis of PHEO in this patient.
Respiratory Support During Pulmonary Artery Thromboembolia (Review)
Authors: Ostapchenko D. A. , Gutnikov A. I. , Rubanova D. V. , Losev A. A. 
Published: March 2020

Pulmonary artery thromboembolia (PATE) is not a clinical entity as such, but a complication of diﬀerent diseases and conditions leading to deep thrombosis in the low tension circulation system, right cardiac chambers or causing local thrombosis in the pulmonary artery system. PATE is characterized by complex pathogenesis of respiratory failure of varying severity, which makes it diﬃcult to choose a respiratory support technique.Purpose of the overview: to show advantages of diﬀerent respiratory support techniques and prospects of high-ﬂux oxygen therapy with regard to PATE pathophysiology.82 sources were selected based on the principle of combining clinical and experimental data from papers published over the recent 5 years and earlier that are still relevant for medical practice.The overview presents the structure of main causes and prevalence of PATE and considers thrombogenesis stages and predominant manifestations of respiratory failure during PATE occurring due to inconsistency between pulmonary ventilation and perfusion. Review discusses ﬁve methods of respiratory therapy in PATE patients: low-ﬂux and high-ﬂux oxygen therapy, non-invasive and invasive artiﬁcial lung ventilation, extracorporeal blood oxygenation. Finally, the paper shows the eﬃcacy and limitations of these methods.Conclusion. High-ﬂux oxygen therapy seems to be the most eﬀective and promising technique in PATE patients thanks to absence of adverse cardiohemodynamic consequences, subjective comfort for patients, and relation to minimal risks of secondary infectious complications.Nevertheless, the clinical experience accumulated is insuﬃcient to make an absolute choice of one particular technique for respiratory support during PATE. It is necessary to continue investigating the clinical eﬃcacy of high-ﬂux oxygen therapy in the speciﬁc population of patients who experienced PATE.
FEASIBILITY OF RESPIRATORY SYSTEM MODULE BASED ON CREATIVE PROBLEM SOLVING LEARNING MODEL WITH MIND MAPPING TO EMPOWER PROBLEM SOLVING SKILLS
Authors: Sugiyanto Fadilah Nur , Masykuri Mohammad , Muzzazinah Muzzazinah 
Published: March 2020

KELAYAKAN MODUL SISTEM PERNAPASAN BERBASIS CREATIVE PROBLEM SOLVING DISERTAI MIND MAPPING UNTUK MEMBERDAYAKAN KETERAMPILAN PEMECAHAN MASALAH AbstractThe aim of this research is to describe the feasibility of respiratory system module based on Creative Problem Solving learning model with mind mapping to empower problem solving skill. This research was a research and development by using descriptive percentage technique. The feasibility of module is tested through a validation stage by a team of experts, practitioners, and students. Validation results by experts’ show, respiratory system module expressed in appropriate criteria and very good category. This result is supported by the results of the appraisement of practitioners and students with an average grade on very good category. The results indicate that the respiratory system module is worthy can be used to empower problem solving skills.AbstrakPenelitian ini bertujuan mendeskripsikan kelayakan modul sistem pernapasan berbasis model pembelajaran Creative Problem Solving disertai mind mapping untuk memberdayakan keterampilan pemecahan masalah. Penelitian ini merupakan penelitian Research & Develompment (R&D) dengan menggunakan teknik deskriptif persentase. Hasil validasi modul sistem pernapasan oleh ahli dengan kriteria layak dan dengan kategori sangat baik. Hasil tersebut didukung oleh hasil penilaian praktisi pendidikan dan siswa, dengan kategori nilai rata-rata sangat baik. Hasil ini mengindikasi bahwa modul sistem pernapasan hasil pengembangan layak digunakan untuk memberdayakan keterampilan pemecahan masalah.kurang, 15% dengan kategori kurang, 3% dengan kategori baik, dan 27% dengan kategori sangat baik.
THE CONTRIBUTION OF CONTENT, PEDAGOGY, AND TECHNOLOGY ON THE FORMATION OF SCIENCE TEACHERS’ TPACK ABILITY
Authors: Yulisman Hendra , Widodo Ari , Riandi Riandi , Nurina Cut Intan Evtia 
Published: March 2020

KONTRIBUSI PENGETAHUAN KONTEN, PEDAGOGI, DAN TEKNOLOGI TERHADAP PEMBENTUKAN TPACK GURU IPA AbstrakModel integrasi teknologi mengalami perubahan dari model yang berfokus pada teknologi ke model yang berfokus pada pedagogi, salah satunya adalah TPACK. Informasi mengenai kemampuan TPACK guru IPA dan kontribusi pengetahuan konten, pedagogi, dan teknologi dalam pembentukan TPACK guru masih belum banyak tersedia. Oleh sebab itu, penelitian ini bertujuan untuk memperoleh informasi mengenai kemampuan TPACK guru IPA dan kontribusi pengetahuan konten, pedagogi, dan teknologi dalam pembentukan TPACK. Penelitian survei ini melibatkan 88 orang guru mata pelajaran IPA Kota Banda Aceh. Data mengenai kemampuan TPACK guru diperoleh dari soal tes berbentuk pilihan berganda. Penyebaran soal dilakukan secara langsung melalui kegiatan pelatihan. Analisis data dilakukan secara statistik deskriptif dan inferensial (pemodelan SEM-PLS). Hasil penelitian menunjukkan bahwa profil kemampuan TPACK guru IPA SMP di Kota Banda Aceh didominasi oleh pengetahuan konten (CK). Hasil analisis SEM-PLS menunjukkan bahwa CK, PK, dan PCK secara langsung dan tidak langsung berkontribusi dalam pembentukan TPACK guru IPA SMP di Kota Banda Aceh. Pemerintah dan penyelenggara pendidikan diharapkan dapat membantu guru untuk meningkatkan kemampuan menggunakan teknologi secara efektif dalam kegiatan pembelajaran agar terbentuk TPACK yang komprehensif.AbstractThe model of technology integration has changed from models that focus on technology to models that focus on pedagogy, one of which is TPACK. The information about science teachers’ TPACK and the contribution of content, pedagogy, and technology on the formation of science teachers’ TPACK is still limited. Therefore, this research aimed to obtain information about the science teachers’ TPACK and the contribution of content, pedagogy, and technology on the formation of TPACK. This survey research involved 88 science teachers from Banda Aceh City. The data about science teachers’ TPACK was obtained from multiple-choice test questions. The questions were distributed directly through training activities. Data analysis was performed by descriptive and inferential statistics (SEM-PLS modeling). The results showed that the TPACK ability profile of junior high school science teachers in Banda Aceh City was dominated by content knowledge (CK). The results of the SEM-PLS analysis showed that CK, PK, and PCK, directly and indirectly, contributed to the formation of the science teachers’ TPACK in junior high school in Banda Aceh City. The government and education providers were expected to be able to help teachers to improve the ability to use technology effectively in learning activities to form a comprehensive TPACK.
EFEKTIFITAS PELATIHAN LABORATORIUM VIRTUAL SEBAGAI MEDIA PEMBELAJARAN BAGI GURU KIMIA
Authors: Lutfi Achmad , Sukarmin Sukarmin 
Published: March 2020

EFFECTIVITY OF VIRTUAL LABORATORY TRAINING AS A LEARNING MEDIA FOR CHEMISTRY TEACHERSAchmad Lutfi, SukarminUniversitas Negeri Surabaya, Indonesia achmadlutfi@unesa.ac.idAbstractThe study aims to determine the level of training achievement using virtual laboratories for chemistry teachers on the ability of teachers to use virtual laboratories and the achievement of objectives in learning chemistry using virtual laboratories. The training was conducted for chemistry teachers who were members of the City and District High School Chemistry Teachers' Working Group (MGMP). During the study, the teachers were trained in how to install, operate virtual laboratories, and conduct experiments with virtual laboratories. At the end of the activity, an ability test was conducted using a virtual laboratory, giving questionnaires to participants and assigning participant assignments in the form of lesson plans (RPP) with the use of virtual laboratories as learning media. The data obtained showed that 90% of the participating teachers had been able to use virtual laboratory programs, including installing, operating, and conducting experiments with virtual laboratories. 82-100% of the participants found it useful to participate in the activities, and the compiled lesson plans showed that the participants were able to use the virtual laboratory as a medium for chemistry learning with a percentage of 85% -100%, and students gave positive responses and good learning outcomes after participating in chemistry learning with use of virtual laboratories. AbstrakPenelitian bertujuan mengetahui tingkat ketercapaian pelatihan menggunakan laboratorium virtual bagi guru kimia terhadap kemampuan guru menggunakan laboratorium virtual dan ketercapaian pembelajaran kimia dengan menggunakan laboratorium virtual. Pelatihan dilakukan terhadap guru kimia yang tergabung pada Musyawarah Guru Mata Pelajaran Kimia Sekolah Menengah Atas Kota dan Kabupaten Kediri. Selama penelitian dilatihkan cara menginstal , mengoperasikan laboratorium virtual dan melakukan percobaan dengan laboratorium virtual. Pada akhir kegiatan dilakukan tes kemampuan menggunakan laboratorium virtual, pemberian angket kepada peserta dan pemberian tugas peserta berupa pembuatan rencana pelaksanaan pembelajaran (RPP) dengan pemanfaatan laboratorium virtual sebagai media pembelajaran. Data yang diperoleh menunjukkan 90% guru peserta telah mampu menggunakan program laboratorium virtual, meliputi: menginstal, mengoperasikan, dan melakukan percobaan dengan laboratotium virtual. Sebesar 82-100 % peserta merasa bermanfaat mengikuti kegiatan dan RPP yang disusun memperlihatkan bahwa peserta sudah dapat memanfaatkan laboratorium virtual sebagai media pembelajaran kimia dengan prosentasi 85%-100%, serta peserta didik memberikan tanggapan positif dan hasil belajar yang baik setelah mengikuti pembelajaran kimia dengan penggunaan laboratorium virtual.
PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH FISIKA DENGAN MODEL PEMBELAJARAN INQUIRY-DISCOVERY
Authors: Wartono Wartono , Batlolona John Rafafy , Mahfi Rizqi Maulidina 
Published: March 2020

ENHANCEMENT OF PHYSICS PROBLEM-SOLVING SKILLS WITH INQUIRY-DISCOVERY LEARNING MODEL AbstractThe purpose of this study was to determine differences in problem solving abilities of students who were given inquiry-discovery learning through web-assisted empirical-theoretical reviews with students who were given conventional learning. This study uses a quasi-experimental pretest-posttest control group design. The average gain score of the problem solving ability test shows that students who are taught with inquiry-discovery learning through web-assisted empirical-theoretical reviews are higher than students who are taught with conventional learning. Hypothesis test results show that students who are learning with inquiry-discovery learning through web-assisted empirical-theoretical reviews have higher problem solving abilities than students who are taught with conventional learning, this also applies to students with high or low initial abilities. AbstrakTujuan dari penelitian ini adalah untuk mengetahui perbedaan kemampuan pemecahan masalah siswa yang diberi pembelajaran inquiry-discovery melalui tinjuan empiris-teoritis berbantuan web dengan siswa yang diberi pembelajaran konvensional. Penelitian ini menggunakan rancangan quasi exsperiment pretest-posttest control group design. Hasil rata-rata gain score tes kemampuan pemecahan masalah menunjukkan siswa yang dibelajarkan dengan pembelajaran inquiry-discovery melalui tinjuan empiris-teoritis berbantuan web lebih tinggi daripada siswa yang dibelajarkan dengan pembelajaran konvensional. Hasil uji hipotesis menunjukkan bahwa siswa yang dibelajarakan dengan pembelajaran inquiry-discovery melalui tinjuan empiris-teoritis berbantuan web memiliki peningkatan kemampuan pemecahan masalah lebih tinggi daripada siswa yang dibelajarakan dengan pembelajaran konvensional, hal ini juga berlaku pada siswa yang berkemampuan awal tinggi maupun rendah.
Handbook of Research on Digital Content, Mobile Learning, and Technology Integration Models in Teacher Education, edited by Jared Keengwe
Authors: Visedo Elizabeth 
Published: March 2020

Handbook of Research on Digital Content, Mobile Learning, and Technology Integration Models in Teacher Education Edited by Jared Keengwe Hershey, PA: IGI Global US $225 ISBN 9781522529538 (Hardback) 498 pages 2018
Adversarial Attacks on Crowdsourcing Quality Control
Authors: Checco Alessandro , Bates Jo , Demartini Gianluca 
Published: March 2020

Crowdsourcing is a popular methodology to collect manual labels at scale. Such labels are often used to train AI models and, thus, quality control is a key aspect in the process. One of the most popular quality assurance mechanisms in paid micro-task crowdsourcing is based on gold questions: the use of a small set of tasks of which the requester knows the correct answer and, thus, is able to directly assess crowd work quality. In this paper, we show that such mechanism is prone to an attack carried out by a group of colluding crowd workers that is easy to implement and deploy: the inherent size limit of the gold set can be exploited by building an inferential system to detect which parts of the job are more likely to be gold questions. The described attack is robust to various forms of randomisation and programmatic generation of gold questions. We present the architecture of the proposed system, composed of a browser plug-in and an external server used to share information, and briefly introduce its potential evolution to a decentralised implementation. We implement and experimentally validate the gold detection system, using real-world data from a popular crowdsourcing platform. Our experimental results show that crowdworkers using the proposed system spend more time on signalled gold questions but do not neglect the others thus achieving an increased overall work quality. Finally, we discuss the economic and sociological implications of this kind of attack.
Organizational Culture and Job Satisfaction in Bank: Perceptions and Reactions of Employees
Authors: Hakim Md. Abdul 
Published: March 2020

This study examines employees’ perceptions and reactions regarding the organizational culture for their job satisfaction where the five variables or organizational culture are selected as working conditions, compensations, respect from co-workers, relationships with supervisors and opportunity for advancement. The key purpose of this study effort was to investigate how organizational culture can affect job satisfaction of the employees in response their perceptions and reactions towards the organizational culture factors. This study operationally defined culture in terms of working conditions, compensations and benefits, respect from co-workers, relationships with supervisors and opportunity for advancement. To this research, both primary and secondary data are used where the statistical population included the employees of bank organizations in Bangladesh. Almost primary based, the data were collected through the distribution of a standardized questionnaire among 500 employees through convenience sampling. This study revealed that Respects from the co-workers as the components of organizational variable has the most domination in framing Job Satisfaction in respect of the employees perceptions of the bankers where working conditions has the least among five explanatory variables. The statistical result of this paper also found that the selected organizational culture related variables have the direct effect over the level of job satisfaction to either increase or decrease. The results of this study supported the reliability measures of the organizational culture questionnaire over the populations, regardless of the reality that the sample size for this study was inadequate. A further suggestion for future research would be to establish whether improving measurement and response mechanisms in the jobs of social workers would positively influence job satisfaction and perception of organizational culture by employees in this job category.
Customer Perception on Bank Service Quality: A Comparative Study between Conventional Commercial Banks and Islamic Commercial Banks in Bangladesh
Authors: Rezina Sonia , Ahmad Nur , Mitu Farhana , Mustafi Mohitul Ameen Ahmed 
Published: March 2020

Customer perception refers to the process by which a customer selects, organizes, and interprets information inputs to create a meaningful picture of the service quality within an organization. In the fast growing banking industry like Bangladesh, every bank is looking forward towards faster growth through providing better service quality than others. However, there are certain challenges started rising in front of the booming banking sector which are needed to be addressed immediately; such as, managing compliance, mitigating fraud/ cyber security, managing hiring decisions etc. It is obvious that, those who will efficiently handle these challenges will certainly lead the market and gain higher customer contentment. The main purpose of this study is to compare the customer perception towards the service Quality offered by Conventional Commercial Banks and Islamic Shariah-based Commercial Banks in Bangladesh through using SERVQUAL instrument. 204 respondents have been randomly selected for the study among them 162 is from Conventional banks and 42 are from Islamic banks. The findings of the research should help the policy makers and regulators in banking industry to have a deep insight towards the different perception of customers and assist in taking effective measures to achieve organizational goal through improving their service Quality.
Examining the Performance of Islamic Banks in the Context of Bangladesh
Authors: Siddiqua Ayesha 
Published: March 2020

As a unique banking system Islamic Banking gained popularity all over the world. In 1983 Bangladesh also came forward with Islamic banking. This study focused on the performance of six selected Islamic banks in Bangladesh during 2011-2015. Researchers collected data from the annual reports of the Banks. Variables such as investment, total asset, deposit, earnings per share (EPS), return on asset (ROA) and return on equity (ROE) were selected for the study. In this study the main tools were growth and trend analysis. This empirical investigation revealed that the growth of total asset, deposit and investment was up to the mark but the Banks were not able to increase the growth rate of EPS, ROA and ROE. The result also showed that Islamic banks are doing good job in Bangladesh although the Banks are operating according to the conventional banking framework.
JEL Classification Code: G 21