bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between dietary patterns and cognitive ability in 10-15 years old Chinese children: evidence from the 2010 China Family Panel Studies
Authors: Wang Tiantian , Cao Shiyi , Li Dandan , Chen Fan , Jiang Qingqing , Zeng Jing 
Published: April 2020

Abstract
Background Limited study is currently available concerning the associations between dietary patterns and cognitive ability during childhood and adolescence, especially studies come out of Chinese data. Our aim was to analyze the associations between dietary patterns and cognitive ability in 10 to 15 year-old Chinese children. Methods 2029 children’s dietary, cognitive ability and sociodemographic data were available from the 2010 China Family Panel Studies (CFPS). Dietary patterns were identified by the principal component method (PCA). Associations between dietary patterns and cognitive ability were assessed using Ordinal-Logistic regression models. Results Three dietary patterns were identified namely as ‘High protein’, ‘High fat’ and ‘High salt-oil’. Following adjustment for the gender, age, nationality, household registration, school, parents’ education, family education environment, family annual income and family size, we found that higher score on the ‘High protein’ pattern was associated with higher scores of mathematics test (OR=1.62; CI: 1.23~2.15; P=0.001) but was not significant with vocabulary test (OR=1.21; CI: 0.93~1.58; P=0.149). Higher score on the ‘High fat’ pattern was associated with lower score of mathematics (OR=0.76; CI: 0.59~0.98; P=0.031) and vocabulary test (OR=0.77; CI: 0.61~0.97; P=0.029). There was no significance between ‘High salt-oil’ pattern and mathematics (OR=0.99; CI:0.77~1.27; P=0.915) and vocabulary test (OR=0.93; CI:0.73~1.18; P=0.544). Conclusions The study indicated that ‘High protein’ pattern may has positive associations with cognitive ability in Chinese children, while ‘High fat’ pattern may has negative associations.
The practice of dentistry by Australian- and overseas-trained dentists in Australia: discriminant analysis of key predictors
Authors: Balasubramanian Madhan , Spencer A John , Sohn Woosung , Brennan David S 
Published: April 2020

Abstract
Introduction: Overseas-trained dentists comprise a significant proportion of the Australian dental workforce. The aim of the study was to examine characteristics and practice variations between Australian- and overseas-trained dentists, with an intent to identify key predictors that best differentiates Australian- and overseas-trained dentists’ practice of dentistry in Australia. Methods: Data for the study were from the Longitudinal Study of Dentist Practice Activity (LSDPA), a survey of a nationally representative random sample of dentists in Australia commencing 1983-84 and followed every five years. Dentists were surveyed on a wide range of items including participant characteristics, practice patterns, practice inputs, direct demand and productivity measures. Data were weighted to national estimates by age, sex and practice type. Discriminant function analysis was used to examine the effects of predictor variables that best separated dentists to Australian- or overseas-trained. Results: A total of 1148 dentists (response rate =67 %) responded to the survey in 2009-10; 648 complete cases were available for the discriminant analysis. The discriminant functions for the full sample, and each of the three age groups (<35 yrs; 35-50 yrs & 50+ yrs) were found effective to seperate dentists into two groups (Australian and overseas), with the proportion of cases correctly classified being highest for the oldest age group (89.7% for 50+yrs). Gender (being female), type of practice (working in public sector), and SEIFA (working at disadvantaged areas) were significant predictors, with more prominence in the 35-50 yrs age group. Practice inputs, demand and productivity measures offered less discriminative capacity between Australian- and overseas-trained dentists. Conclusion: Overseas-trained dentists contribute towards providing dental care to underserved population, public sector and in rural and remote locations. This study provided some basis to argue that policies to encourage overseas-trained dentists to contribute towards areas of need locations in Australia have been successful. Key productivity measures of overseas trained dentists mimicked those of Australian-trained dentists.
Spontaneous intracranial hypotension combined with subarachnoid hemorrhage: report of 2 cases
Authors: Cao Ya , Na Weinan , Su Hui , Wang Xiaolin , Dong Zhao , Yu Shengyuan 
Published: April 2020

Abstract
Background: Spontaneous intracranial hypotension (SIH) combined with subarachnoid hemorrhage (SAH) has rarely been reported. Herein, we report two patients with SIH who suffered from diffuse non-aneurysmal SAH and expanded the symptom spectrum of SIH.Case report: ① A 55-year-old male was diagnosed with SIH based on orthostatic headache and diffuse pachymeningeal enhancement on brain MRI. One more month later, his headache was exacerbated, and brain CT showed diffuse SAH. Lumber puncture showed bloody CSF with a low CSF pressure of 20 mmH2O after a 30 ml intrathecal injection of saline. The patient was treated with a lumbar epidural blood patch and recovered. ② A 41-year-old male presented with orthostatic headache and nuchal pain. The brain CT scan confirmed the diagnosis of SAH. Brain MRI revealed diffuse dural thickening and bilateral frontoparietal subdural fluid collection. Lumber puncture showed bloody CSF with low CSF pressure. Then, an epidural blood patch was performed with satisfactory results.Conclusion: Dilation and rupture of intracranial venous structures might play significant roles in SIH combined with SAH. We should be alert to SIH patients who develop a new persistent severe headache without relief after lying down or a suddenly changed state of consciousness.
Headache is associated with aberrant cerebral blood flow in chronic tinnitus revealed by perfusion functional MRI
Authors: Chen Yu-Chen , Hu Jinghua , Cui Jinluan , Shang Song’an , Yong Wei , Xu Jin-Jing , Yin Xindao , Wu Yuanqing , Qi Jianwei 
Published: April 2020

Abstract
Background: Chronic tinnitus is often accompanied with headache symptom that will affect the cerebral blood flow (CBF) and exacerbate the tinnitus distress. However, the potential relationship between headache and tinnitus remains unclear. This study will investigate whether aberrant CBF patterns exist in chronic tinnitus patients and examine the influence of headache on CBF alterations in chronic tinnitus. Methods: Participants included chronic tinnitus patients (n=45) and non-tinnitus controls (n=50), matched for age, sex, education, and hearing thresholds. CBF images were collected and analyzed using arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between tinnitus patients and non-tinnitus controls were first detected. The interaction effects between headache and tinnitus for CBF alterations were further examined. Correlation analyses illustrated the association between CBF values and tinnitus severity as well as between CBF and degree of headache.Results: Compared with non-tinnitus controls, chronic tinnitus patients exhibited decreased CBF, primarily in right superior temporal gyrus (STG), bilateral middle frontal gyrus (MFG), and left superior frontal gyrus (SFG); decreased CBF in these regions was correlated with tinnitus distress. There was a significant interaction effect between headache and tinnitus for CBF in right STG and MFG. Moreover, the degree of headache correlated negatively with CBF in tinnitus patients.Conclusions: Chronic tinnitus patients exhibited reduced CBF in the auditory and prefrontal cortex. Headache may facilitate a CBF decrease in the setting of tinnitus, which may underlie the neuropathological mechanisms of chronic tinnitus comorbid with headache.
Identification of WTAP-related genes by weighted gene co-expression network analysis in ovarian cancer
Authors: Wang Jing , Xu Jing , Li Ke , Huang Yunke , Dai Yilin , Xu Congjian , Kang Yu 
Published: April 2020

Abstract
Background : WTAP modulating other genes in the manner of transcriptional and post-transcriptional regulation, in particular, acting as a N6-methyladenosine writer or binding to the 3’-untranslated region of mRNA, promotes a variety of tumors. However, its roles and mechanisms in ovarian cancer are unknown. Results : In this study, using univariate Cox analysis and online CPTA analysis, we found that WTAP was a poor prognostic factor for ovarian cancer and its protein expression level was higher in ovarian cancer compared to normal tissue. Subsequently, we identified a module containing 133 genes that were carefully related to WTAP expression through weighted gene co-expression network analysis. By calculating hazard ratio of these genes and comparing their differences in the WTAP high-expression group and the low-expression group, we noticed there was a significantly positive correlation between WTAP and two poor survival-related genes: FAM76A and HBS1L. Conclusion : Our research suggests that the WTAP-HBS1L / FAM76A axis may play an essential role in ovarian cancer progression and provide new ideas for ovarian cancer research.
DNA methylation-based classification and identification of bladder cancer prognosis-associated subgroups
Authors: Tian Zijian , Meng Lingfeng , Long Xingbo , Diao Tongxiang , Hu Maolin , Wang Miao , Liu Ming , Wang Jianye 
Published: April 2020

Abstract
Background : Bladder cancer (BCA) is the most common urinary tumor, but its pathogenesis is unclear, and the associated treatment strategy has rarely been updated. In recent years, a deeper understanding of tumor epigenetics has been gained, providing new opportunities for cancer detection and treatment.Methods : We identified prognostic methylation sites based on DNA methylation profiles of BCA in the TCGA database and constructed a specific prognostic subgroup.Results : Based on the consistent clustering of 402 CpGs, we identified seven subgroups that had a significant association with survival. The difference in DNA methylation levels was related to T stage, N stage, M stage, grade, sex, age, stage and prognosis. Finally, the prediction model was constructed using a Cox regression model and verified using the test dataset; the prognosis was consistent with that of the training set.Conclusions : The classification based on DNA methylation is closely related to the clinicopathological characteristics of BCA and determines the prognostic value of each epigenetic subtype. Therefore, our findings provide a basis for the development of DNA methylation subtype-specific therapeutic strategies for human bladder cancer.
Proteasome inhibition restored the reduced expression of fibroblast growth factor receptor 3 in rheumatoid arthritis synovial fibroblasts
Authors: Neidhart Michel , Karouzakis Emmanuel , Fucentese Sandro , Distler Oliver , Jüngel Astrid 
Published: April 2020

Abstract
Background. Synovial hyperplasia is a hallmark of rheumatoid arthritis (RA). This might be associated with an imbalance of growth-promoting and apoptotic pathways, among them fibroblast growth factors (FGFs) and their receptors (FGFRs) . The aim was to investigate differences in FGFRs and to explore the factors that might explain the differences between RA and osteoarthritis (OA) synovial fibroblasts. Methods. To assess FGFRs expression, immunohistochemistry, flow cytometry and RT-qPCR were performed. The cells were treated with TNFa, FGF2, a demethylation agent, PKA-mimics or inhibitors, hypoxia-mimics or proteasome inhibitors. Proliferation was measured using the CCK8 assay and 20S proteasome activity by a fluorescent assay. Results. In RA, FGFR3 protein was decreased in the synovial lining layer (p<0.005) and in cultured RA synovial fibroblasts (RASF) (n=10, p < 0.01). Transcription was unchanged and DNA demethylation decrease its expression. Exposure to TNFa or FGF2 had no effect on FGFR3. PKA-modulation and hypoxia-mimics induced transient changes only. Most interesting, in RASF, the proteasome inhibitor MG-132 restored FGFR3 expression (p<0.001) to levels measured in normal or OA synovial fibroblasts. MG-132 abolished the enhanced proliferative response of RASF to FGF2 (p<0.005). Increased 20S proteasome activity correlated (r=- 0.63, p<0.05) with decreased expression of FGFR3. Conclusions. The expression of FGFR3 is reduced in RA partially due to an increased degradation in proteasomes. This leads to an imbalance in the FGF-related signal pathways and may contribute to synovial hyperplasia. Proteasome inhibitors could represent a novel therapeutic strategy in RA, particularly to prevent synovial hyperplasia.
Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy
Authors: Ku Chee Wai , Zhang Xiaoxuan , Østbye Truls , Allen John Carson , Zhang Valencia , Tan Thiam Chye 
Published: April 2020

Abstract
BACKGROUND: Progesterone is a steroid hormone that is critical for implantation and maintenance of pregnancy, with low levels being associated with a significantly higher miscarriage risk. Despite its pivotal role, especially during early pregnancy, reference range studies of serum progesterone are predominantly trimester-specific with wide ranges that are not clinically useful. Although it is established that serum progesterone exhibits an overall increasing trend during pregnancy, little is known about its trajectory during early pregnancy. We sought to find the gestational age-specific normative values and trajectory of serum progesterone, and its associated maternal and fetal factors, during the first trimester of a viable low-risk pregnancy.METHODS: A prospective cohort study was conducted at KK Women’s and Children’s Hospital from 1 April 2012 to 31 January 2018, recruiting 590 women with a single intrauterine low-risk pregnancy, presenting at antenatal clinics between gestational weeks 5 to 12. Gestational age-specific normative values and trajectory of serum progesterone were determined via quantile regression. Maternal and fetal characteristics that influence normative values of serum progesterone were determined via univariable analyses followed by multivariable regression. RESULTS: Serum progesterone showed an increasing trend during the first trimester of a viable low-risk pregnancy, with a transient decline between gestational weeks 6 to 8 corresponding to the luteal-placental shift. Lowest levels were seen at week 7 (mean serum progesterone of 75.0 nmol/L at week 5 versus 63.4 nmol/L at week 7, p=0.029; 63.4 nmol/L at week 7 versus 78.0 nmol/L at week 9, p<0.001). In a multivariable logistic regression, gestational age, maternal age, maternal body mass index at presentation, parity and fetal gender were found to be associated with progesterone levels, explaining 18.8% of the variability. CONCLUSIONS: Our study described the gestational age-specific normative values and increasing trajectory of serum progesterone, with a physiological decline during weeks 6 to 8 of gestation. This forms the basis for future work on pathological levels of serum progesterone that may lead to miscarriage. Larger studies are also required to investigate the need for normative values to be developed, and personalized to account for maternal BMI, parity and fetal gender.
The triglyceride glucose index (TyG) and CDKAL1 gene rs10946398 SNP are associated with NAFLD in Chinese adults
Authors: Zhu Jun , Xu Dujuan , Yang Ruihua , Liu Min , Liu Ying 
Published: April 2020

Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) has a higher prevalence worldwide, and its pathogenesis is not clear. Genetic factors, dyslipidaemia and dysglycaemia have been proven to be associated with NAFLD. It has not been reported whether the triglyceride glucose index (TyG), which is estimated by triglyceride and fasting glucose, has a relationship with NAFLD in people from North China. Whether the CDKAL1 gene rs10946398 SNP, which has been found to be associated with BMI, has a relationship with TyG and NAFLD is not clear. Methods: We recruited a total of 1,760 subjects in this study, and we measured the clinical characteristics, abdominal ultrasound, and genotype of those participants. Results: The results showed that 527 (29.9%) subjects suffered from NAFLD, the TyG index was associated with NAFLD (OR=5.456, 95% CI (3.526~8.442)), and the CDKAL1 gene rs10946398 SNP has a relationship with NAFLD (OR=1.509, 95% CI (1.046~2.178)). The distribution of the C allele of rs10946398 was statistically significant at different levels of the TyG index. Conclusion: We identified an association between the rs10946398 genotypes of CDKAL1 and NAFLD and the TyG index, and the TyG index was related to the risk of NAFLD.
Planning and optimising a digital intervention to reduce older adults’ cognitive decline
Authors: Essery Rosie , Pollet Sebastien , Smith Kirsten A. , Mowbray Fiona , Slodkowska-Barabasz Joanna , Denison-Day James , Hayter Victoria , Bradbury Katherine , Grey Elisabeth , Western Max J. , Milton Alexander , Ferrey Anne E. , Müller Andre Matthias , Stuart Beth , Mutrie Nanette , Griffin Simon , Kendrick Tony , Gudgin Bernard , Phillips Rosemary , Stokes Tom , Niven John , Little Paul , Yardley Lucy 
Published: April 2020

Abstract
Background By 2050 worldwide dementia prevalence is expected to triple, rising to 152 million. Affordable, scalable interventions are required to support protective behaviours such as physical activity, cognitive training and healthy eating. This paper outlines the development of ‘Active Brains’: a multi-domain digital behaviour change intervention to reduce cognitive decline amongst older adults, and key findings arising from this process. Methods A theory-, evidence- and person-based approach to intervention development was undertaken. Scoping reviews and behavioural analysis contributed to intervention planning. Optimisation involved qualitative interviews with 52 older adults with higher and lower cognitive performance scores. Data were analysed thematically and informed changes. Results The development process synthesised findings from planning and optimisation activities. Scoping reviews and qualitative interviews suggested that the same intervention content should be suitable for individuals with higher and lower cognitive performance. Qualitative findings revealed that maintaining independence and enjoyment motivated engagement in intervention-targeted behaviours, whereas managing ill health was a potential barrier. Social support for engaging in such activities could provide motivation, but was not desirable for all. These findings informed development of highly acceptable intervention content and functionality for target users. Conclusions A digitally-delivered intervention with minimal support appears acceptable and potentially engaging to older adults with higher and lower levels of cognitive performance. As well as informing our own intervention, the insights obtained through our development process may be useful for others working with, and developing interventions for, older adults and/or those with cognitive impairment.
Relationship of chest CT score with clinical characteristics of 108 patients hospitalized with COVID-19 in Wuhan, China
Authors: Zhang Jie , Meng Guangping , Li Wei , Shi Bingqing , Dong Hongna , Su Zhenzhong , Huang Qian , gao peng 
Published: April 2020

Abstract
Background: In December 2019, the outbreak of a disease subsequently termed COVID-19 occurred in Wuhan, China. The number of cases increased rapidly and spread to six continents. However, there is limited information on the chest computed tomography (CT) characteristics of affected patients. Objective: Analyze COVID-19 patients to determine the relationships of clinical characteristics, chest CT score, and levels of inflammatory mediators . Methods: This retrospective, single-center case series of 108 consecutive hospitalized patients with confirmed COVID-19 at Tongji Hospital, Tongji Medical College of HUST (Wuhan, China) was performed from January 1 to January 28, 2020. Patient demographics, comorbidities, clinical findings, chest CT results, and CT scores of affected lung parenchyma were recorded. The relationships between chest CT score with levels of systemic inflammatory mediators were determined. Results: All patients exhibited signs of significant systemic inflammation, including increased levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin, chest CT score, and a decreased lymphocyte (LY) count. Chest CT score had positive associations with white blood cell (WBC) count, CRP, ESR, procalcitonin, and abnormal coagulation function, and a negative association with LY count. Treatment with a glucocorticoid increased the LY count, reduced the CT score and CRP level, and improved coagulation function. Conclusions: COVID-19 infection is characterized by a systemic inflammatory response that affects the lungs, blood, digestive system, and circulatory systems. The chest CT score is a good indicator of the extent of systemic inflammation. Glucocorticoid treatment appears to reduce systemic inflammation in these patients.
Explore the self-care needs in patients with cancer; a qualitative content analysis
Authors: Mazhari Fariba , Khoshnood Zohreh 
Published: April 2020

Abstract
Background ‏ : Cancer is one of the most critical health problems worldwide today. Studies by different researchers have shown that disease can reduce people's ability to self-care. Therefore, this study was conducted to investigate Self-care needs in patients with cancer.Methods ‏ : ‏ This study is a conventional, qualitative content. Data saturation achieved after interviewing 13 participants in 15 interviews. With the in-depth semi-structured approach, the participants were asked to narrate their experiences of Self-care needs in the process of disease. The analysis was done according to Graneheim and Lundman's method, the following considered: the unit of analysis, meaning unit, condensation, code, sub-category ‏,‏ category, and main category.Results ‏ : Data analysis leads to two main categories of the two main categories of "Deficiency in management of disease". Including three sub-categories: "the need to get rid of annoying physical symptoms"," Need for a caregiver in daily routine," and" Feeling frustrated and giving up treatment". The second main category of "the need for sympathetic and knowledgeable caregivers" with the following five sub-categories: "Need for sympathy and interaction with nurse", "the need to hear the truth about illness", " Need for appropriate therapeutic interaction from physicians", "Inadequate qualification of physicians' secretary about the patient", and" need for a psychologist for psychological adaptation. "Conclusion ‏ : ‏ The most critical needs are compassionate and informed caregivers. So nursing management and care with kindness, competence, and conscience is the fundamental right of patients with cancer. Identifying the needs and problems of patients can be used as a background for increasing the knowledge and experience of nurses and providing care for patients with cancer.