bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol for a two-cohort randomized cluster clinical trial of a motor skills intervention: The Promoting Activity and Trajectories of Health (PATH) Study
Authors: Robinson Leah E. , Wang Lu , Colabianchi Natalie , Stodden David F , Ulrich Dale 
Published: June 2020

IntroductionData supports that motor skills are an underlying mechanism that influence physical activity along with perceived motor and physical competence, but the relationship between motor skills and physical activity during the early years is unclear. The goal of this study, Promoting Activity and Trajectories of Health (PATH) for Children, is to examine and compare the immediate (pre-test to post-test) and sustained (3-year follow-up) effect of an intervention on motor performance, physical activity and perceived physical competence to a control condition (ie, standard practice) in preschool-age children.Methods and analysisThe PATH study is a two-cohort, randomised cluster clinical trial. 300 children between the ages of>3.5 to 5 years of age will be randomised to the motor skill intervention (n=153) or control (n=147) condition. Each assessment involves a measure of motor skill performance; product and process, seven consecutive days of physical activity monitoring and perceived physical competence. These measures will be assessed before and after the intervention (pre-test to post-test) and then each academic year across 3 years, grades kindergarten, first grade and second grade (3-year follow-up). To assess the clustered longitudinal effect of the intervention on outcome measures, random-effects models (eg, mixed model regression, growth curve modelling and structural equation modelling) will be used. The PATH study addresses gaps in paediatric exercise science research. Findings hold the potential to help shape public health and educational policies and interventions that support healthy development and active living during the early years.Ethics and disseminationEthical approval for this study was obtained through the Health Sciences and Behavioral Sciences Institutional Review Board, University of Michigan (HUM00133319). The PATH study is funded by the National Institutes of Health. Findings will be disseminated via print, online media, dissemination events and practitioner and/or research journals.Trial registration numberNHLBI ClinicalTrials.gov Identifier,NCT03189862. Registered 17 August 2017,https://clinicaltrials.gov/ct2/show/NCT03189862
Neurocognitive impairment after neonatal sepsis: protocol for a systematic review and meta-analysis
Authors: Pek Jen Heng , Yap Bei Jun , Gan Ming Ying , Seethor Shu Ting Tammie , Greenberg Rachel , Hornik Christoph Paul Vincent , Tan Bobby , Lee Jan Hau , Chong Shu-Ling 
Published: June 2020

IntroductionThe effect of neonatal sepsis on the developing brain is not well documented. We aim to perform evidence synthesis to determine the outcome of neurodevelopmental impairment and intellectual disability among survivors of neonatal sepsis. The data gathered will inform on the long-term neurocognitive outcomes of neonates with sepsis and the measures used to document their developmental disability.Methods and analysisWe will perform a search based on the following parameters: neonates and infants less than 90 days old diagnosed with sepsis who had neurocognitive outcomes or measures of developmental disability reported. We will search PubMed, Cochrane Central, Embase and Web of Science for articles in English language published between January 2010 and December 2019. Clinical trials and observational studies will be included. Two independent reviewers will screen studies for eligibility. Data extraction will then be performed using a standardised form. The quality of evidence and risk of bias will be assessed using Cochrane Collaboration’s tool and Risk of Bias in Non-randomised Studies of Intervention (ROBINS-I). The results will be synthesised qualitatively and pooled for meta-analysis.Ethics and disseminationNo formal ethical approval is required as there is no collection of primary data. This systematic review and meta-analysis will be disseminated through conference meetings and peer-reviewed publications.PROSPERO registration numberRegistration submitted CRD42020164334
Economic analysis of the prevalence and clinical and economic burden of medication error in England
Authors: Elliott Rachel Ann , Camacho Elizabeth , Jankovic Dina , Sculpher Mark J , Faria Rita 
Published: June 2020

ObjectivesTo provide national estimates of the number and clinical and economic burden of medication errors in the National Health Service (NHS) in England.MethodsWe used UK-based prevalence of medication errors (in prescribing, dispensing, administration and monitoring) in primary care, secondary care and care home settings, and associated healthcare resource use, to estimate annual number and burden of errors to the NHS. Burden (healthcare resource use and deaths) was estimated from harm associated with avoidable adverse drug events (ADEs).ResultsWe estimated that 237 million medication errors occur at some point in the medication process in England annually, 38.4% occurring in primary care; 72% have little/no potential for harm and 66 million are potentially clinically significant. Prescribing in primary care accounts for 34% of all potentially clinically significant errors. Definitely avoidable ADEs are estimated to cost the NHS £98 462 582 per year, consuming 181 626 bed-days, and causing/contributing to 1708 deaths. This comprises primary care ADEs leading to hospital admission (£83.7 million; causing 627 deaths), and secondary care ADEs leading to longer hospital stay (£14.8 million; causing or contributing to 1081 deaths).ConclusionsUbiquitous medicines use in health care leads unsurprisingly to high numbers of medication errors, although most are not clinically important. There is significant uncertainty around estimates due to the assumption that avoidable ADEs correspond to medication errors, data quality, and lack of data around longer-term impacts of errors. Data linkage between errors and patient outcomes is essential to progress understanding in this area.
Acute carotid stenting in patients undergoing thrombectomy: a systematic review and meta-analysis
Authors: Dufort Gabrielle , Chen Bing Yu , Jacquin Grégory , Keezer Mark , Labrie Marilyn , Rioux Bastien , Stapf Christian , Ziegler Daniela , Poppe Alexandre Y 
Published: June 2020

BackgroundThe benefit of acute carotid stenting compared with no acute stenting on clinical outcomes among patients with tandem lesions (TL) undergoing endovascular thrombectomy (EVT) remains unknown.MethodsWe conducted a a systematic review and meta-analysis of studies comparing acute carotid stenting versus no stenting among TL patients undergoing EVT with regards to 90 day modified Rankin Scale (mRS) score, symptomatic intracerebral hemorrhage (sICH), and mortality. Four reviewers screened citations for eligibility and two assessed retained studies for risk of bias and data extraction. A random effects model was used for the synthesis of aggregated data.Results21 studies (n=1635 patients) were identified for the systematic review; 19 were cohort studies, 1 was a post-hoc analysis of an EVT trial, and 1 was a pilot randomized controlled trial. 16 studies were included in the meta-analysis. Acute stenting was associated with a favorable 90 day mRS score: OR 1.43 (95% CI 1.07, 1.91). No significant heterogeneity between studies was found for this outcome (I2=17.0%; χ2=18.07, p=0.26). There were no statistically significant differences for 3 month mortality (OR 0.80 (95% CI 0.50, 1.28)) or sICH (OR 1.41 (95% CI 0.91, 2.19)).ConclusionsThis meta-analysis suggests that among TL patients undergoing EVT, acute carotid stenting is associated with a greater likelihood of favorable outcome at 90 days compared with no stenting.
Aneurysm treatment with WEB in the cumulative population of two prospective, multicenter series: 3-year follow-up
Authors: Pierot Laurent , Szikora Istvan , Barreau Xavier , Holtmannspoetter Markus , Spelle Laurent , Herbreteau Denis , Fiehler Jens , Costalat Vincent , Klisch Joachim , Januel Anne-Christine , Weber Werner , Liebig Thomas , Stockx Luc , Berkefeld Joachim , Moret Jacques , Molyneux Andy , Byrne James 
Published: June 2020

BackgroundWEB treatment is an endovascular approach for wide-neck bifurcation aneurysms that has demonstrated high safety and good efficacy in mid-term follow-up. While evaluating safety in the long term is important to determine if delayed adverse events occur affecting late morbidity and mortality, the most important point to evaluate is the long-term stability of aneurysm occlusion. The current analysis reports the 3-year clinical and anatomical results of WEB treatment in the combined population of two European trials (WEBCAST (WEB Clinical Assessment of Intrasaccular Aneurysm Therapy) and WEBCAST-2).MethodsAneurysm occlusion was evaluated using a 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant.ResultsThe safety population comprised 79 patients. The efficacy population comprised 61 aneurysms. Aneurysm locations were middle cerebral artery in 32/61 aneurysms (52.5%), anterior communicating artery in 13/61 (21.3%), basilar artery in 9/61 (14.8%), and internal carotid artery terminus in 7/61 (11.5%). No adverse events related to the device or procedure occurred between 2 and 3 years. At 3 years, complete occlusion was observed in 31/61 (50.8%) aneurysms, neck remnant in 20/61 (32.8%), and aneurysm remnant in 10/61 (16.4%). Between 1 year and 3 years, aneurysm occlusion was improved or stable in 53/61 (86.9%) aneurysms and worsened in 8/61 (13.1%). Worsening was mostly from complete occlusion to neck remnant in 6/61 (9.8%) aneurysms. The retreatment rate at 3 years was 11.4%.ConclusionsThis analysis confirms the high safety profile of WEB. Moreover, evidence demonstrates the great stability of aneurysm occlusion with adequate occlusion (complete occlusion or neck remnant) in 83.6% of aneurysms.Clinical trial registrationURL:http://www.clinicaltrials.gov. WEBCAST and WEBCAST-2: Unique identifier:NCT01778322.
Enhancing phosphorus release from struvite with biostimulants
Authors: Hernández Jiménez Juan Esteban , Nyiraneza Judith , Fraser Tandra D. , Peach Brown Helen Carolyn , Lopez-Sanchez Idalia Jacqueline , Botero-Botero Liliana Rocio 
Published: June 2020

Struvite is a phosphorus (P)-rich by-product of wastewater treatment facilities that can be recycled as a P source in agriculture. Because struvite is not water soluble, it is solubilized gradually by organic acids released by soil microorganisms and from growing plant roots when used as fertilizer. To speed up the solubilization process, struvite can be combined with biostimulants such as P-solubilizing bacteria (PSB) or earthworm casts (WC). The objective of this greenhouse study was to compare the fertilizer value of struvite, with and without PSB (Bacillus megaterium) or WC, with that of triple superphosphate in two contrasting soils (a low-P soil and a high-P soil). Oat (Avena sativa L.) was grown for 8 wk under a controlled environment, and dry matter yield at harvest, total N and total P uptake, the soil residual Mehlich-3 P, and phosphomonoesterase activity were measured. The high-P soil was unresponsive to P application, but the low-P soil was responsive. In the low-P soil, there was more Mehlich-3-extracted P when struvite was combined with PSB or WC compared with struvite alone, resulting in greater oat dry matter and more total N and more total P uptake. Combining struvite with biostimulants increased total dry matter and total P uptake by an average of 39% and 33%, respectively. We conclude that greater P release from struvite occurs when it is combined with PSB or WC, particularly in low-P soil, but this needs to be confirmed in field-scale studies.
Soil nitrous oxide emissions most sensitive to fertilization history during a laboratory incubation
Authors: Giweta Mekonnen , Dyck Miles , Malhi Sukhdev S. , Puurveen Dick , Quideau S.A. 
Published: June 2020

A 12 wk laboratory incubation examined the effects of application of various nitrogen (N) and sulfur (S) fertilizers on soil plant-available nutrient levels and nitrous oxide (N2O) gas emissions with respect to soil fertilization history using soils sampled from the University of Alberta Breton Classical Plots. Fertilization history and added fertilizer treatments showed significant effects on N2O emissions and NO3−-N and SO4−-S recovered on ion-exchange resins over the 12 wk. Mean cumulative N2O emissions ranged from 0.43 to 1.18 kg N2O-N ha−1. The relationship between observed total resin-recovered NO3−-N and N2O emissions was not consistent for soils receiving long-term applications of various combinations of N, phosphorus, potassium, and S fertilizers. The N2O emission from two soils with a history of long-term N fertilizer applications but different S fertilization histories was significantly different even though resin-recovered NO3−-N levels were similar. When grouped according to added fertilizer treatments, mean cumulative N2O emissions showed a strong linear relationship with mean resin-adsorbed NO3−-N production. We hypothesize that the differences in the relationship between NO3−-N production and N2O-N emissions for soils with different long-term fertilization histories may be a result of the interaction of N and S oxidation processes. Further, soil fertilization history may significantly influence soil N2O emissions in response to N fertilizers added within the growing season of observation but isn’t often considered in short-term experiments, and this may be a significant source of uncertainty in the estimation of greenhouse gases inventories from agricultural soils.
Optimal networks for exact controllability
Authors: Liao Yunhua , Maama Mohamed , Aziz-Alaoui M. A. 
Published: June 2020

The exact controllability can be mapped to the problem of maximum algebraic multiplicity of all eigenvalues. In this paper, we focus on the exact controllability of deterministic complex networks. First, we explore the eigenvalues of two famous networks, i.e. the comb-of-comb network and the Farey graph. Due to their special structure, we find that the eigenvalues of each network are mutually distinct, showing that these two networks are optimal networks with respect to exact controllability. Second, we study how to optimize the exact controllability of a deterministic network. Based on the spectral graph theory, we find that reducing the order of duplicate sets or co-duplicate sets which are two special vertex subsets can decrease greatly the exact controllability. This result provides an answer to an open problem of Li et al. [X. F. Li, Z. M. Lu and H. Li, Int. J. Mod. Phys. C 26, 1550028 (2015)]. Finally, we discuss the relation between the topological structure and the multiplicity of two special eigenvalues and the computational complexity of our method.
Bidirectional quantum-controlled teleportation using six-qubit cluster state without remote joint operation
Authors: Yuan Hao , Pan Guo-Zhu 
Published: June 2020

Utilizing a six-qubit cluster state as quantum channel, a bidirectional controlled quantum teleportation (BCQT) scheme was put forward by Yan in [Int. J. Theor. Phys. 52, 3870 (2013)]. However, in order to accomplish the task, two agents must cooperate to perform a quantum controlled phase gate operation on their two qubits. In view of the present technique, such kind of remote joint operation is difficult to be realized. In this paper, based on the same cluster state, we propose a different BCQT scheme to avoid the remote joint operation. Besides, an unnecessary waste of classical messages in Yan’s scheme is point out.
Rock magnetic study on the Yetti–Eglab Intrusions, Sahara: contribution to the West African Craton geology
Authors: Aïfa Tahar , Merabet Nacer-Eddine 
Published: June 2020

Abstract
New palaeopoles have been calculated for the West African Craton (WAC) using palaeomagnetic data obtained on 178 cores of the Yetti–Eglab intrusions and stromatolite-bearing formation. One, two or three components of magnetization on 172 (14 sites) and 37 (6 sites) oriented specimens or cores were isolated mainly on doleritic dykes. High and low unblocking temperature components were evidenced in the dykes but also at four sites of the well-dated Hank stromatolite-bearing formation (875–890 Ma). Rock magnetic analyses show stable remanent magnetizations mainly carried by magnetite (or titanomagnetite) but may also reveal the presence of hematite, pyrrhotite and goethite. Regarding the recently constructed apparent polar wander path of the WAC until 500 Ma, these newly computed remanent components seem to be mainly older, some of which could be remagnetizations at different periods. However, according to geological dating and literature, the Yetti and Eglab terranes belonging to the WAC were amalgamated around 1.9 Ga and involved in the formation of the Columbia Supercontinent. The palaeopole computed for the stromatolite-bearing formation corresponds with the location of Rodinia Supercontinent at its early stages of amalgamation. The geodynamic evolution of the WAC with respect to both supercontinents suggests that the Eglab and Yetti could be separated by oceanic crust before 1.9 Ga. A volcanic arc developed during the subduction of this ocean followed by crustal thickening that generated an intrusive suite (Aftout granites) when it was at low northern latitudes. Baltica and Rio de la Plata cratons were close to the WAC after 1.7 Ga, following a nearly similar path between 1.7 and 0.9 Ga. In Africa, the collapse of the Birimian orogen was probably contemporaneous with the fragmentation of Columbia. At 0.9 Ga, Baltica was probably not attached to the WAC since the latter was not affected by the later Grenvillian orogen.
S, R, and data science
Authors: Chambers John M. 
Published: June 2020

Data science is increasingly important and challenging. It requires computational tools and programming environments that handle big data and difficult computations, while supporting creative, high-quality analysis. The R language and related software play a major role in computing for data science. R is featured in most programs for training in the field. R packages provide tools for a wide range of purposes and users. The description of a new technique, particularly from research in statistics, is frequently accompanied by an R package, greatly increasing the usefulness of the description.
The history of R makes clear its connection to data science. R was consciously designed to replicate in open-source software the contents of the S software. S in turn was written by data analysis researchers at Bell Labs as part of the computing environment for research in data analysis and collaborations to apply that research, rather than as a separate project to create a programming language. The features of S and the design decisions made for it need to be understood in this broader context of supporting effective data analysis (which would now be called data science). These characteristics were all transferred to R and remain central to its effectiveness. Thus, R can be viewed as based historically on a domain-specific language for the domain of data science.
Biomarkers and Strategy to Detect Preinvasive and Early Pancreatic Cancer: State of the Field and the Impact of the EDRN
Authors: Liu Ying , Kaur Sukhwinder , Huang Ying , Fahrmann Johannes F. , Rinaudo Jo Ann , Hanash Samir M. , Batra Surinder K. , Singhi Aatur D. , Brand Randall E. , Maitra Anirban , Haab Brian B. 
Published: June 2020

AbstractPatients afflicted with pancreatic ductal adenocarcinoma (PDAC) face a dismal prognosis, but headway could be made if physicians could identify the disease earlier. A compelling strategy to broaden the use of surveillance for PDAC is to incorporate molecular biomarkers in combination with clinical analysis and imaging tools. This article summarizes the components involved in accomplishing biomarker validation and an analysis of the requirements of molecular biomarkers for disease surveillance. We highlight the significance of consortia for this research and highlight resources and infrastructure of the Early Detection Research Network (EDRN). The EDRN brings together the multifaceted expertise and resources needed for biomarker validation, such as study design, clinical care, biospecimen collection and handling, molecular technologies, and biostatistical analysis, and studies coming out of the EDRN have yielded biomarkers that are moving forward in validation. We close the article with an overview of the current investigational biomarkers, an analysis of their performance relative to the established benchmarks, and an outlook on the current needs in the field. The outlook for improving the early detection of PDAC looks promising, and the pace of further research should be quickened through the resources and expertise of the EDRN and other consortia.See all articles in this CEBP Focus section, “NCI Early Detection Research Network: Making Cancer Detection Possible.”
Detection of Head and Neck Cancer Based on Longitudinal Changes in Serum Protein Abundance
Authors: Lee Ju Yeon , Shi Tujin , Petyuk Vladislav A. , Schepmoes Athena A. , Fillmore Thomas L. , Wang Yi-Ting , Cardoni Wayne , Coppit George , Srivastava Shiv , Goodman Joseph F. , Shriver Craig D. , Liu Tao , Rodland Karin D. 
Published: June 2020

AbstractBackground:Approximately 85% of the U.S. military active duty population is male and less than 50 years of age, with elevated levels of known risk factors for oropharyngeal squamous cell carcinoma (OPSCC), including smoking, excessive use of alcohol, and greater numbers of sexual partners, and elevated prevalence of human papilloma virus (HPV). Given the recent rise in incidence of OPSCC related to the HPV, the Department of Defense Serum Repository provides an unparalleled resource for longitudinal studies of OPSCC in the military for the identification of early detection biomarkers.Methods:We identified 175 patients diagnosed with OPSCC with 175 matched healthy controls and retrieved a total of 978 serum samples drawn at the time of diagnosis, 2 and 4 years prior to diagnosis, and 2 years after diagnosis. Following immunoaffinity depletion, serum samples were analyzed by targeted proteomics assays for multiplexed quantification of a panel of 146 candidate protein biomarkers from the curated literature.Results:Using a Random Forest machine learning approach, we derived a 13-protein signature that distinguishes cases versus controls based on longitudinal changes in serum protein concentration. The abundances of each of the 13 proteins remain constant over time in control subjects. The AUC for the derived Random Forest classifier was 0.90.Conclusions:This 13-protein classifier is highly promising for detection of OPSCC prior to overt symptoms.Impact:Use of longitudinal samples has significant potential to identify biomarkers for detection and risk stratification.
Advancing Rural Cancer Control Research: National Cancer Institute Efforts to Identify Gaps and Opportunities
Authors: Weaver Sallie J. , Blake Kelly D. , Vanderpool Robin C. , Gardner Brittany , Croyle Robert T. , Srinivasan Shobha 
Published: June 2020

Abstract
Cancer mortality rates are approximately 8% higher in rural populations and mortality rates are falling more slowly in rural communities, resulting in widening rural-urban health disparities in the United States. The NCI has a long history of supporting health disparities research, including research to understand the health needs, strengths, and opportunities in rural communities. However, the portfolio analysis described in this article underscores the need to significantly accelerate rural cancer control research in partnership with state and local communities. This commentary outlines NCI's efforts over the last four years to address gaps in rural cancer control research and improve cancer prevention, control, and care delivery in rural populations. Future directions, challenges, and opportunities are also discussed.