bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gradient local anesthesia for percutaneous endoscopic interlaminar discectomy at the L5/S1 level: a feasibility study
Authors: Feng Wan-Li , Yang Jun-Song , Wei Dongmei , Gong Han-Lin , Xi Yong , Lv Hui-Qiang , Wang Xin-Gang , Xia Bin , Wei Jian-Min 
Published: July 2020

Abstract
Background During the process of shearing the ligamentum ﬂavum, rotating the working channel, and manipulating the annulus fibrosis, the sinuvertebral nerve and the spinal nerve root can be irritated, inducing intolerable back and leg pain. Thus, GA is recommended and well accepted by most surgeons when performing PELD via the interlaminar approach. The aim of our study was to explore the efficacy and safety of percutaneous endoscopy interlaminar lumbar discectomy with gradient LA in patients with L5/S1 disc herniation. Methods This retrospective study was conducted between December 2017 and June 2018. The study included 50 consecutive patients who met the study criteria, had single-level L5/S1 disc herniation, and underwent PELD via the interlaminar approach under gradient LA. Different concentrations of LAC were injected into different tissues inside and outside the ligamentum flavum to complete gradient LA. The evaluation criteria included the intraoperative satisfaction score, VAS score, ODI, complications and adverse reactions. Results The intraoperative satisfaction score was consistently over 7, with an average score of 9.3±0.7, indicating that LAC can achieve satisfactory pain control throughout the PELD operation without additional anesthesia. The postoperative VAS score and ODI were dramatically improved at each follow-up interval (P < 0.001, respectively). There was no serious complication such as dural rupture caused by puncture, dural laceration caused by manipulation under endoscopy, total spinal anesthesia, iatrogenic nerve root injury, epidural hematoma, infections or local anesthetic-related adverse reactions. Three patients experienced transient postoperative dysesthesia of the lower limbs that gradually recovered within 24 hours. Conclusions Gradient local anesthesia can satisfactorily and safely control intraoperative pain during the PELD via the interlaminar approach. It can not only improve intraoperative satisfaction, but also reduce local anesthesia-related adverse reactions and surgery-related complications.
We have the program, what now? Development of an implementation strategy to bridge the research-practice gap prevalent in exercise oncology
Authors: Kennedy Mary Ann , Bayes Sara , Newton Robert U. , Zissiadis Yvonne , Spry Nigel A. , Taaffe Dennis R. , Hart Nicolas H. , Davis Michael , Eiszele Aileen , Galvão Daniel A. 
Published: July 2020

Abstract
Background Exercise has emerged as a promising therapy for people with cancer. Novel programs have been developed to translate this research into practice; however, implementation barriers have limited their success. The aim of this study was to employ the implementation mapping protocol to develop an implementation strategy to effectively support programming of a co-located exercise clinic and cancer treatment center. Methods The Implementation Mapping protocol, which consists of five specific, iterative tasks, was employed for this study. Data from interviews, surveys, clinic records, and implementation science literature was used to develop a comprehensive implementation strategy for the co-located exercise clinic. A stakeholder advisory group advised throughout the process. Results The organization’s general manager was identified as the program adopter; oncologists, center leaders, and various administrative staff as program implementers; and the operations manager as the program maintainer. Twenty performance objectives were identified and used to inform the development of a comprehensive theory-based implementation plan consisting of seven implementation strategies across the individual and organizational levels, including use of program champions and an implementation advisor, and revision of professional roles. Finally, an evaluation plan was developed to measure the success of the implementation strategy. Conclusion Successful translation of exercise oncology research into practice requires context-specific implementation plans. The Implementation Mapping protocol provided a roadmap to guide development of a robust implementation strategy that considered all ecological domains, was informed by theory, and demonstrated an extensive understanding of the implementation context. Strong research-practitioner partnerships and effective stakeholder engagement were critical to successful execution of the protocol.
Nomogram for Prediction of fatal outcome in Patients with Severe COVID-19 Pneumonia: A Multicenter Study
Authors: Yang Yun , Zhu Xiaofei , Huang Jian , Chen Cui , Zheng Yang , He Wei , Zhao Linghao , Gao Qian , Huang Xuanxuan , Fu Lijuan , Zhang Yu , Chang Yanqin , Zhang Huojun , Lu Zhijie 
Published: July 2020

Abstract
Background & Aims: To develop an
effective model of predicting fatal
Outcome in the severe coronavirus disease 2019
(COVID-19) patients.
Methods: Between February 20, 2020
and April 4, 2020, consecutive COVID-19 patients from three
designated hospitals were enrolled in this study. Independent high-
risk factors associated with death were analyzed using Cox
proportional hazard model. A prognostic nomogram was constructed to
predict the survival of severe COVID-19 patients.
Results: There were 124 severe
patients in the training cohort, and there were 71 and 76 severe
patients in the two independent validation cohorts, respectively.
Multivariate Cox analysis indicated that age ≥ 70 years (HR 1.184,
95% CI 1.061-1.321), Panting(breathing rate ≥ 30/min) (HR 3.300,
95% CI 2.509-6.286), lymphocyte count < 1.0 × 109/L
(HR 2.283, 95% CI 1.779-3.267), and IL-6 >10pg/mL (HR 3.029, 95%
CI 1.567-7.116) were independent high-risk factors associated with
fatal outcome. We developed the nomogram for identifying survival
of severe COVID-19 patients in the training cohort (AUC 0.900, [95%
CI 0.841-0.960], sensitivity 95.5%, specificity 77.5%); in
validation cohort 1 (AUC 0.862, [95% CI 0.763-0.961], sensitivity
92.9%, specificity 64.5%); in validation cohort 2 (AUC 0.811, [95%
CI 0.698-0.924], sensitivity 77.3%, specificity 73.5%). The
calibration curve for probability of death indicated a good
consistence between prediction by the nomogram and the actual
observation.
Conclusions: This nomogram could
help clinicians to identify severe patients who have high risk of
death, and to develop more appropriate treatment strategies to
reduce the mortality of severe patients.
Keywords: Severe COVID-19;
Nomogram; Prediction; Survival;
Colossal Permittivity and Multiple Effects in (Zn + Ta) co-doped TiO2 Ceramics
Authors: Fan Jiangtao , Yang TianTian , Cao Zhenzhu 
Published: July 2020

Abstract
The search for giant dielectric constant materials is imperative because of their potential for important applications for the areas of device miniaturization and energy storage. In this work, we report a (Zn + Ta) co-doped TiO2 (ZTTO) ceramics that manifests high dielectric permittivity (>104) and low dielectric loss. This dielectric property shows a high stability in wide temperature range (25-200℃) and frequency range(20-106Hz). The crystalline structure, microstructure and dielectric properties of ZTTO ceramics were systematically investigated. XPS, Impedance spectroscopy and frequency dependent dielectric constant under DC bias results reveal that the colossal dielectric properties of (Zn2+1/3Ta5+2/3)xTi1-xO2 ceramics were mainly caused by electron-pinned defect-dipoles (EPDD) model, internal barrier layer capacitance (IBLC) effect and electrode effect. This work would provide a guidance to further researching the colossal permittivity CP materials.
Application of Nano-Carbon and Titanium Clip Combined Labeling in Robot-Assisted Laparoscopic Transverse Colon Cancer Surgery
Authors: Lin Nan , Qiu Jiandong , Song Junchuan , Yu Changwei , Fang Yongchao , Wu Weihang , Yang Weijin , Wang Yu 
Published: July 2020

Abstract
Introduction: Robot-assisted laparoscopic transverse colon tumor surgery requires precise tumor localization. The purpose of this study was to evaluate the safety and efficacy of nano-carbon and titanium clip combination labeling methods in robot-assisted transverse colon tumor surgery.Methods: From January 2018 to January 2019, the clinical data of 16 patients who underwent preoperative nano-carbon and titanium clip combined with robot-assisted laparoscopic transverse colon cancer surgery were retrospectively analyzed.Results: Of the 16 patients, no signs of abdominal pain, fever, or diarrhea were observed after colonoscopy. Two titanium clips were seen on all of the 16 patients' abdominal plain films. Nano-carbon staining sites were observed during the operation, and no staining disappeared or abdominal cavity contamination. All patients underwent R0 resection. The average number of lymph nodes harvsted was 18.23±5.04 (range, 9-32). The average time to locate the lesion under the laparoscopic was 3.03±1.26 min(range, 1-6min), and the average operation time was 321.43±49.23 min (range, 240-400min). All were consistent with the surgical plan, and there was no intraoperative change of surgical procedure or conversion to open surgery.Conclusion: Preoperative colonoscopy combined with nano-carbon and titanium clip is safe and effective in robot-assisted transverse colon cancer surgery. A At the same time, the labeling method shows potential in shortening the operation time, ensuring sufficient safety margin and reducing complications.
Exploring the usability of the COM-B model and Transtheoretical Domains Framework (TDF) to define the underlying helpers and hindrances of evidence-based change in midwifery
Authors: De Leo Annemarie , BAYES Sara , BLOXSOME Dianne , BUTT Janice 
Published: July 2020

Abstract
Background
Despite the ongoing production of new scientific evidence in the field of maternity care, midwives continue to face challenges when translating latest evidence into evidence-informed care, and report reticence towards implementing evidence-based change in clinical areas. This study aimed to explore midwifery leaders’ views on what factors help or hinder midwives’ efforts to implement evidence-based practice, and test the usability of the Capability, Opportunity, Motivation and Behaviour model and Transtheoretical Domains Framework to analyse the barriers and facilitators to evidence-based change.
Methods
This qualitative study formed part of a larger Participatory Action Research (PAR) project designed to improve the processes by which midwives implement evidence-based practice change in clinical areas. Data were obtained from a focus group workshop and individual face-to-face interviews between July – September 2019. Thematic analysis was used to interpret the transcribed data, which were then coded and categorised into meaningful themes.
Results
One overarching core finding emerged from four major categories: Fear can stop change and midwives are reticent towards evidence-based change; however, inter-disciplinary collaboration and midwives in leadership roles is a huge advantage.
Conclusion
This study confirms what is known about the helpers and hinderances of evidence-based change, and provides valuable insight into the usability of behavioural theories and context assessment tools to both diagnose and develop implementation strategies applicable to midwives in clinical areas.
Factors associated with the practice of exclusive breastfeeding for six months among mothers on antiretroviral therapy in the Eastern Cape, South Africa
Authors: GOON PROF DANIEL TER , Ajayi Anthony Idowu , ADENIYI OLADELE VINCENT 
Published: July 2020

Abstract
Background
Despite the beneficial health effects of exclusive breastfeeding (EBF) for infants, the practice of EBF remains low in South Africa, a country burdened with HIV. Given that the factors limiting EBF are multi-factorial and context-specific, we sought to examine the factors influencing EBF practice among mothers on antiretroviral therapy (ART) in the Eastern Cape, South Africa.
Methods
This was a prospective cross-sectional study of 469 parturient women enlisted in the prevention of mother-to-child HIV transmission cohort study in the Eastern Cape. A structured questionnaire was used to collect relevant socio-demographic, lifestyle and maternal information. Bivariate and multivariate logistic regression analyses were performed to assess associations between socio-demographic, lifestyle factors and EBF.
Results
EBF for six months was practised by a few women (32.0%). The prevalence of EBF was significantly higher among married women (36.8%), unemployed women (36.6%), non-smokers (32.7%), and those who never drank alcohol (37.0%). Unemployed women (AOR = 1.66, 95% CI: 1.08–2.56) and those with grade 12 or less level of education (AOR = 2.76, 95% CI: 1.02–7.49) had a higher likelihood of practising EBF for six months compared to employed women and women who attained tertiary level of education. While mothers who take alcohol (AOR = 0.54, 95% CI: 0.34–0.85) were less likely to practice EBF for six months compared to those who never drank alcohol.
Conclusions
Factors contributing to the low prevalence of EBF among mothers in this setting are employment, tertiary education and alcohol consumption. Strategies should target these socioeconomic indicators and lifestyle behaviour in the region.
The Awareness of Women on Prostate Cancer: A Mixed-Methods Systematic Review Protocol
Authors: Wiafe Ebenezer , Mensah Kofi Boamah , Mensah Adwoa Bemah Boamah , Bangalee Varsha , Oosthuizen Frasia 
Published: July 2020

Abstract
Background: Prostate cancer accounts for about 10% of cancers affecting and claiming the lives of men. Studies have reported that women are better than men in recognition of the early manifestations of various cancers. Besides, women have been recognized to show a profound interest in their partners' health and hence, make observations that men don't know. Several studies have reported on the knowledge gaps of prostate cancer among patients and the general population. It is vital to comprehensively review the available evidence and identify research gaps in our current understanding of knowledge of women on prostate cancer.Methods: A search of bibliographic databases, MEDLINE (EBSCOhost), CINAHL (EBSCOhost), PsycINFO (EBSCOhost), Web of Science, and EMBASE (Ovid) will be undertaken from January 1999 to December 2019. The search will be limited to studies published in the English language. Duplication of studies will be removed using the EndNote citation manager. After deduplication, citations will be screened independently by two authors according to prespecified criteria. Data extraction and quality assessment of the selected studies will be done independently by two authors. Meta-analytic methods will be used where appropriate. The convergent segregated method of synthesis will be adopted in this review. Ethics and dissemination: Primary data collection will not be involved in this study, hence formal ethical clearance will not be needed. The results of the study will be presented through a peer-reviewed journal and conference presentation.Patient and public involvement: Patients or the public will not be engaged in the conduct of this study.Trial registration number: Open Science Framework (OSF) registration DOI: https://doi.org/10.17605/OSF.IO/EYHF2
Structural stigma and its impact on healthcare for consumers diagnosed with Borderline Personality Disorder: protocol for a scoping review
Authors: Klein Pauline , Fairweather-Schmidt A. Kate , Lawn Sharon , Stallman Helen , Cammell Paul 
Published: July 2020

Abstract
BackgroundStructural stigma in health systems experienced by consumers diagnosed with Borderline Personality Disorder (BPD), is a widespread phenomenon that causes health inequities and harm for this population. Structural stigma in this context relates to organisational practices, cultural norms, and institutional policies that limits consumers’ access to health services, quality of care, and health and well-being. BPD is a mental illness with high morbidity and mortality, characterised by instability in interpersonal relationships, self-image, and emotional and behavioral deregulation, which stem from significant traumatic childhood/life events, and/or biological etiologies. This scoping review aims to explore the literature on structural stigma in health systems specific to BPD, and to provide an overview of the impact of stigma on healthcare services for BPD consumers, and their carers/families.MethodsThis scoping review will follow the Joanna Briggs Institute (JBI) guidelines. The search strategy was developed and tested using PsycINFO. A comprehensive search will be conducted across PsycINFO, MEDLINE, CINAHL, Scopus, ProQuest, Cochrane library and JBI Evidence-Based databases; as well as a grey literature search using Google search engine. Studies will be screened by title, abstract and full text articles, by separate reviewers against the eligibility criteria. Selected full text articles will be accessed against the inclusion criteria. Quantitative and qualitative data will be extracted from the selected full text articles. A narrative summary of findings will then be conducted and presented in accordance with the JBI guidelines for scoping reviews, and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) 2015 checklist. Quality appraisal of the included articles will be assessed using the Mixed Methods Appraisal Tool (MMAT) 2018 version.DiscussionThis review is anticipated to enhance both identification and understanding of those structures in health systems (i.e., policies, cultural norms, and practices), that manifest and perpetuate stigma experienced by consumers with BPD, and their carers/families. The findings can be used to inform future research, policy and practice relating to stigma reduction strategies that can be adopted to improve the provision of BPD-responsive services and care for this population.Scoping review registrationThis scoping review was submitted for registration in Open for Science Framework on 11th June 2020.
Women’s experiences of planning a home birth with maternity care providers in middle to high-income countries: a systematic review protocol
Authors: Healy Maria , Bamidele Olufikayo , Gillen Patricia 
Published: July 2020

Abstract
Background: A woman’s choice of birth place does not only influence her birth experience, but also impacts on maternal and neonatal outcomes. For healthy women who have had a straightforward pregnancy, a planned home birth supported by midwives and other maternity care providers, is now a recognised choice within their individual country’s health care system. However, there is limited evidence on women’s actual experiences of engaging with maternity care providers to plan for a home birth, especially within the context of middle to high-income countries where there is integration of maternity care services. Therefore, this systematic review will synthesise findings from previous studies, which have reported on women’s experiences of planning a home birth in consultation with maternity care providers, in middle to high-income countries.Methods: Using a systematic approach, we will develop a search strategy to identify relevant research studies on women’s experiences of planning a home birth, with the support of their maternity care providers. Search terms will be iteratively developed using text words derived from the review aim, the PICO framework and database-indexed terms. In May 2020, the searches will be conducted on seven bibliographic databases: Ovid Medline, Embase, PsycInfo, and CINAHL plus, Scopus, ProQuest and Cochrane (Central and Library) from January 2015 to 26th May 2020. Supplementary searches will also be undertaken to identify additional articles. At least two reviewers will do the screening, quality appraisal, data extraction and analysis. Included studies will be appraised using a quality appraisal tool suited to the study design. Data will be analysed using either a narrative or thematic synthesis depending on the methodological design of the studies included. Discussion: Review findings will provide useful recommendations to improve care and support provided for women when planning a home birth. We will publish review findings in a peer-reviewed journal and present it at relevant conferences while also sharing summaries with maternity care providers and service users via social media fora. PROSPERO registration ID: CRD42018095042
U-Shaped Association Between Serum Bilirubin Levels and Peripheral Arterial Disease in Chinese Males with Hypertension
Authors: Shi Yumeng , Hu Lihua , Li Minghui , Huang Xiao , Ding Congcong , Zhou Wei , Wang Tao , Zhu Lin juan , Bao Huihui , Cheng Xiaoshu 
Published: July 2020

Abstract
Background: Previous studies indicated that serum total bilirubin might play an important role in peripheral artery disease (PAD). However, the effects of different levels of serum total bilirubin (TBiL) on PAD development remain an uncertainty and had limited data in male participants. We aimed to examine the prevalence of PAD and TBiL among Chinese male adults with hypertension.Methods: A total of 5129 hypertension male subjects aged 27-93 years was included in the current study. The outcome was a peripheral arterial disease (PAD), defined as present when ABI of either sides was ≤ 0.90.Results: Of 5,129 hypertension male participants, 194 (3.78%) had PAD, and the median serum concentrations of TBiL were 14.10 μmol/L (interquartile range 11.00 to18.60 μmol/L). Compared to participants in Q2-Q3 of LgTBiL, there was a significantly increased risk of PAD for participants in both Q1 (OR,1.49; 95%CI: 1.04-2.14) and Q4 (OR,1.70; 95%CI: 1.16-2.48). After adjusting for potential confounders, a nonlinear U-shaped relationship was detected between TBiL and PAD, and calculated the inflection point was 1.08 (LgTBiL = 1.08, TBiL = 12.02 μmol/L). The ORs (95% CIs) were 0.11 (0.02, 0.83) on the left side of an inflection point and 5.26 (1.59, 17.38) on the right side of the inflection point, respectively. Similar results were found in various subgroups.Conclusions: This cross-sectional study had shown that there was a U-shaped curve for the risk of PAD with TBiL concentration in Chinese males with hypertension, with a turning point at 12.02 μmol/L.