bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnant Women's Perceptions of Anaemia in Pregnancy at the Urban Health Facility in Ahougnansou (Centre-north Côte D'ivoire)
Authors: ANOUA Adou Serge Judicaël 
Published: July 2020

Abstract
Background

Anaemia in pregnancy is an issue of concern in the reduction of reproductive health morbidity in Côte d’Ivoire. This research aimed to describe the meaning of anaemia and analyze its explanatory factors from the perspective of pregnant women in a hospital setting in Ahougnansou in the city of Bouaké in the Centre-North of Côte d’Ivoire.
Methods

This qualitative research was descriptive-interpretive. Using this approach, individual interviews were conducted with twenty (20) participating pregnant women. The research took place in the hospital environment of Ahougnansou in the city of Bouaké in Côte d’Ivoire. The data were analyzed using a conventional inductive content analysis supported by a thematic grid.
Results

Perceptions have identified anaemia in pregnancy as a life-threatening reproductive morbidity for both mother and child. Its specific image has been associated with a lack of blood in the body. Symptoms have included fever, dizziness, fatigue, lack of appetite, pallor and thinness. Its aetiology has been attributed to food bans. In addition, the explanatory logics noted its link with irrational health behaviours such as irregular consultations, inaccessibility to edifying advice, lack of early detection, lack of use of daily oral iron and folic acid supplementation, lack of mobilization of financial resources and non-observance of a balanced diet.
Conclusion

Examination of the social representation of anaemia in pregnancy leads to relevant insights into the irrational health behaviours of pregnant women. On the other hand, the search for appropriate and effective long-term solutions to this reproductive health morbidity requires the immersion of midwives in the living environment of pregnant women and specific community health actions in populations that can be located in space and time in order to circumscribe the reproductive practices involved in resistance to nutritional recommendations in the prenatal period.
Preterm birth determinants among newborns at six public hospitals in Northeast Amhara, Ethiopia: unmatched case-control study
Authors: Shiferaw Mesfin , Tebeje Nigusie Birhan , Mekonnen Habtamu Sewunet 
Published: July 2020

Abstract
Background: Preterm birth is a global public health problem. Worldwide, every year about 15 million newborns are born preterm and about 1.1 million of them die due to complications related to prematurity. More than 81% of preterm births were in Asia and Sub-Saharan Africa. Nowadays, preterm birth is the first leading cause of under-five mortality and is one of the limiting factors for achieving a reduction in under-five mortality rate. Therefore, the aim of this study was to identify the determinants of preterm birth at public hospitals in the Northeast Amhara, Ethiopia, 2019.Method: Hospital-based unmatched case-control study was conducted at public hospitals in Northeast Amhara, Ethiopia from March 15th to April 25th, 2019. Data were collected using interviewer-administered structured pre-tested tool and document review for cases and controls. Data were entered in to Epi Info version 7.2.2.6 and exported to SPSS version 23 software for data analysis. Bi-variable and multivariable binary logistic regression were used to measure the association between preterm birth and risk factors. Adjusted Odds ratio (AOR) at 95 % confidence interval (CI) was calculated and P value ≤0.05 declared statistically significant. Result: The study identified that ANC follow up less than four visits [AOR 2.267, Cl (1.205, 4.264)], pregnancy-induced hypertension [AOR 4.453, Cl (1.276, 15.536)], no iron/folic acid supplementation during pregnancy [AOR 4.175, Cl (1.632, 10.680)], anemia during pregnancy [AOR 4.776, Cl (1.492, 15.285)], and birth defect [AOR 6.160, Cl (l.896, 20.013)] were significantly associated determinants of preterm birth.Conclusion: Antenatal care follow up fewer than four visits, pregnancy induced hypertension, no iron/folic acid supplementation during pregnancy, being anemic during pregnancy, and birth defect were important determinants of preterm birth.
A Randomized Clinical Trial of Prehabilitation Using Aquatic Exercise in Older Adults with Knee Osteoarthritis Undergoing Total Knee Arthroplasty
Authors: Kim Sunghye , Hsu Fang-Chi , Groban Leanne , Williamson Jeff , Messier Stephen 
Published: July 2020

Abstract
Background: With an aging population, knee osteoarthritis (KOA) is increasingly more prevalent. A significant number of patients with advanced KOA require total knee arthroplasty (TKA). Preoperative physical function predicts postoperative outcomes. We hypothesized that preoperative water exercise to improve preoperative physical function will improve postoperative outcomes after TKA.Methods: We conducted a randomized controlled trial in 43 participants who were scheduled for TKA and scored at or below 50th percentile in mobility assessment tool-sf (MAT-sf). All enrolled participants were assessed on 1) clinical osteoarthritis symptom severity using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), 2) physical function using Short Physical Performance Battery (SPPB), 3) self-reported mobility using Mobility Assessment Tool-short form (MAT-sf), 4) depression using Geriatric Depression Scale-short form (GDS-sf), 5) cognitive function using Montreal Cognitive Assessment (MoCA). High-sensitivity-C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels were analyzed. Participants were randomly assigned to the aquatic exercise intervention (AEI) or usual care group. The AEI was conducted three times a week for 4-8 weeks, with each session lasting for 60 minutes. Participants in both groups were evaluated within one week before their scheduled surgery, as well as 4 weeks after the surgery. Logistic regressions were used to examine the associations between the intervention and unfavorable outcomes.Results: The mean age was 67.1 (±6.2), 44% were female, 74% were White. There is no statistically significant difference in combined outcome of any complication, unscheduled ER visit, and disposition to nursing home or rehab facility by AEI. However, AEI was associated with more favorable functional outcomes including WOMAC scores, chair-stand, MAT-sf, as better mood and cognition and lower blood pressure in multivariable analyses.Conclusion: 4-8 weeks of aquatic exercise intervention resulted in improved functional outcomes in patients undergoing TKA. A larger study is warranted to explore the role of water exercise in clinical and functional outcomes of TKA.Trial registration: This clinical trial was registered at ClinicalTrials.gov with ClinicalTrials.gov Identifier of NCT02773745. The date of registration was March 16th 2016. The URL of the trial registry record is https://www.clinicaltrials.gov/ct2/show/NCT02773745?term=water&recrs=e&cond=Osteoarthritis%2C+Knee&cntry=US&draw=2&rank=2.
Association between open tibia fractures and acute compartment syndrome: a retrospective cohort study
Authors: Gamulin Axel , Wuarin Lydia , Zingg Matthieu , Belinga Patrick , Cunningham Gregory , Gonzalez Amanda I. 
Published: July 2020

Abstract
Background
the aim of this study was to determine if an open tibia fracture is at increased risk to be associated with acute compartment syndrome (ACS), when compared to a closed tibia fracture.
Methods
a cohort of 711 consecutive adult patients sustaining 725 tibia fractures between January 2005 and December 2009 were included in this retrospective study. The outcome measure was ACS, which was clinically diagnosed. The following variables were assessed: soft tissue condition (closed, open Gustilo type 1 or open Gustilo type 2 and 3); low- vs. high-energy injury; associated contiguous skeletal injury; type of fracture (proximal intra-articular, extra-articular, distal intra-articular). A logistic regression model was used to measure the association between ACS and the variables. Adjustment was performed for age and sex. Statistical significance was defined as p < 0.05.
Results
fractures occurred at a mean age of 44.6 ±17.4 years and among 477 (65.8%) men, and ACS occurred in 10.4% of proximal intra-articular fractures, 10.4% of extra-articular fractures and 3.3% of distal intra-articular fractures. ACS occurred in 8.7% of closed fractures, 7.8% of open Gustilo 1 fractures and 13.3% of open Gustilo 2 and 3 fractures. Open fractures were not associated with ACS occurrence when tibia fractures were considered as a whole. When stratifying by types of fractures, open Gustilo 2 and 3 fractures were associated with ACS in proximal intra-articular fractures. No association with closed or any type of open fractures was highlighted for extra-articular fractures. There were not enough ACS cases among distal intra-articular fractures to draw conclusions.
Conclusions
this study highlighted an association between open Gustilo type 2 and 3 lesions and occurrence of ACS in proximal intra-articular fractures only (AO/OTA 41B and C). This finding must raise the level of suspicion of any surgeon treating this kind of injuries, especially if the patient is intubated, sedated or obtunded. As ACS can occur with any type of open tibia fractures, clinicians should not be wrongly reassured by an open fracture, assuming that the wound would relieve the pressure inside the muscle compartments.
Minimally Invasive Surgery for Intra-Articular Calcaneus Fractures: A 9-year, Single-Center, Retrospective Study of A Standardized Technique Using A 2-Point Distractor
Authors: Rodemund Christian , Krenn Ronny , Kihm Carl , Leister Iris , Ortmaier Reinhold , Litzlbauer Werner , Schwarz Angelika , Mattiassich Georg 
Published: July 2020

Abstract
Background: A fracture of the calcaneus can be a painful and disabling injury. Treatment modalities may be conservative or operative, as in open reduction and internal fixation (ORIF) via different approaches, including a number of minimally invasive methods. The aim of this study was to evaluate the treatment options and post-treatment complication rates for intra-articular calcaneal fractures at the Traumacenter Linz over a 9-year period.Methods: All patients with calcaneal fractures treated at the Traumacenter Linz between 2007 and 2016 were included in this study. The patients’ protocols were retrospectively reviewed, and the data, including demographic parameters, cause of injury, and the time between the accident and the first operative treatment were analyzed. Secondary operative interventions due to soft-tissue complications, hardware removal, and the long-term arthrodesis rate were evaluated. Results: A minimally invasive 2-point-distractor method was used in 85.8% (n=182) of all operatively managed calcaneal fractures (n=236) in our department. The majority of the operations (88.7%) were performed within two days after the accident. The secondary operation rate resulting from wound complications was 2.7% in the 2-point distractor group and 16.7% in the ORIF group. A secondary arthrodesis was performed in 4.7% (n=9) of the subtalar joints in the entire study population. Conclusions:Our data supported the assumption that severe wound complications would be less likely to occur after minimally invasive treatment compared to ORIF treatment. Additionally, our arthrodesis rate was comparable to that in the literature. Trial Registration: Not applicable, level of evidence IV.
Comparison of the Effectiveness of Existential, Cognitive-Existential, and Humanistic-Existential Group Psychotherapy on Psychosomatic Complaints in Women With Type 2 Diabetes Mellitus
Authors: Hanis Ghaffar Nasiri , Sadeghi Masoud , Gholamrezaei Simin 
Published: July 2020

Abstract
Background and aims: A significant amount of previous studies has confirmed the positive effect of existential, cognitive-existential, and humanistic-existential interventions on psychosocial problems with different populations. However, research on the effectiveness and comparison of the effect of these three independent variables on the problem of patients with type 2 diabetes mellitus is novel. So, the purpose of this research is to study the comparison of the effectiveness of existential, cognitive-existential, and humanistic-existential group psychotherapy on psychosomatic complaints among women with type 2 diabetes mellitus.Methods: The method of the research was semi-experimental, and its experimental design includes the pretest, post-test, and two-month follow-up tests with experimental and control parallel groups. Cases of this study included women with type 2 diabetes mellitus referring to the Specialist Diabetes Clinic of Tohid Hospital in Sanandaj in the first three months of 2019. 32 subjects selected by simple random sampling method of this society and were assigned to three experimental and one control group by substituting random method. The data collected based on the scale of psychosomatic complaints Takata & Sakata (2004). After the pre-test, the experimental groups participated in 120-minute sessions for 9 weeks. Data analyzed by the statistical test of repeated measures of the General Linear Model.Results: The results of repeated measures analysis showed that the effect of the interventions in experimental groups of psychosomatic complaints was significant and stable compared to the control group (computed using alpha = 0, 05). The effect of the group humanistic-existential psychotherapy on reducing psychosomatic complaints about women with type 2 diabetes mellitus is stable and significant compared to existential and cognitive-existential psychotherapy (The mean difference is significant at the 0,05 level).Conclusion: The findings show applying cognitive-existential more benefits than the other two method. So, existential-cognitive group therapy could be a selective therapy for reducing psychosomatic complaints about women with type 2 diabetes mellitus.
Efficacy of an online cognitive behavioral therapy program developed for healthcare workers during the COVID-19 pandemic: The REduction of STress (REST) study protocol for a randomized controlled trial
Authors: Weiner Luisa , Berna Fabrice , Nourry Nathalie , Severac François , Vidailhet Pierre , Mengin Amaury C. 
Published: July 2020

Abstract
Background: The acknowledgement of the mental health toll of the COVID-19 epidemic in healthcare workers has increased considerably as the disease evolved into a pandemic status. Indeed, high prevalence rates of depression, sleep disorders and post-traumatic stress disorder (PTSD) have been reported in Chinese healthcare workers during the epidemic peak. Symptoms of psychological distress are expected to be long-lasting and have a systemic impact on healthcare systems, warranting the need for evidence-based psychological treatments aiming at relieving immediate stress and preventing the onset of psychological disorders in this population. In the current COVID-19 context, internet-based interventions have the potential to circumvent the pitfalls of face-to-face formats, and provide the flexibility required to facilitate accessibility to healthcare workers. Online cognitive behavioral therapy (CBT) in particular has proved to be effective in treating and preventing a number of stress-related disorders in populations other than healthcare workers. The aim of our randomized controlled trial study protocol is to evaluate the efficacy of the ‘My Health too’ CBT program – a program we have developed for healthcare workers facing the pandemic -- on immediate perceived stress, and on the emergence of psychiatric disorders at 3- and 6-month follow-up compared to an active control group (i.e., bibliotherapy). Methods: Powered for non-inferiority testing, this six-site open trial involves the random assignment of 120 healthcare workers with stress levels >16 on the Perceived Stress Scale (PSS-10) to either the 7-session online CBT program or bibliotherapy. The primary outcome is the decrease of PSS-10 scores. Secondary outcomes include depression, insomnia, and PTSD symptoms, self-reported resilience and rumination, as well as credibility and satisfaction. Assessments are scheduled at pretreatment, mid-treatment (at 4 weeks), end of active treatment (at 8 weeks) and at 3-month and 6-month follow-up. Discussion: This is the first study assessing the efficacy and the acceptability of a brief online CBT program specifically developed for healthcare workers. Given the potential short- and long-term consequences of the COVID-19 pandemic on healthcare workers’ mental health, but also on healthcare systems, our findings can significantly impact clinical practice and management of the ongoing, and probably long-lasting, health crisis. Trial registration: NCT04362358, registered April 24, 2020.
microRNA-26a Inhibits the Malignant Tumor Behavior of Pancreatic Cancer Cells via Targeting E2F7
Authors: Wang Liang , Li Meijun , Chen Fei 
Published: July 2020

Abstract
Background: Dysregulation of microRNAs (miRNAs) plays important roles in the development of pancreatic cancer (PCa). miR-26a was reported as a tumor suppressor in multiple cancers. The aim of this study was to explore the potential role and molecular mechanism of miR-26a in the progression of PCa.Methods: The expression of miR-26a in PCa tissues and cells was detected by RT-qPCR. The effects of miR-26a on the growth of PCa cells were determined by the cell counting kit-8 (CCK-8) assay, colony formation and flow cytometry. The targets of miR-26a were predicted by miRDB database and confirmed by luciferase report assay. The protein level was detected by western blot. CHIP assay was performed to detect the effects of miR-26 on the transcription of E2F7 targets.Results: miR-26a was down-regulated in PCa tissues and cell lines. Ectopic expressed miR-26a suppressed the proliferation, colony formation and the tumor stem cell properties of PCa cells. The transcription factor E2F7 was identified as a target of miR-26a. MiR-26a bound the 3’-untranslated region (UTR) of E2F7 and inhibited the expression of E2F7 in PCa cells. Decreased miR-26a in PCa tissues was inversely correlated with that of E2F7. miR-26a transcriptionally reduced the expression of VEGFA via suppressing the binding of E2F7 with the promoter of VEGFA. Overexpression of E2F7 attenuated the suppressive role of miR-26a in the proliferation of PCa cells. Consistently, knockout of E2F7 further significantly inhibited the growth of PCa cells combined with miR-26a overexpression.Conclusion: Our results uncovered the novel function of miR-26a/E2F7/VEGFA in the malignancy of PCa, suggesting miR-26a as a potential target for the treatment of patients with PCa.
Analysis of Functional Indices Indicates Multiple Organ Function Damage in Patients with Severe Coronavirus Disease 2019 (COVID-19) Pneumonia
Authors: Feng Shiyan , Wang Fengxin , Cai Zhao , Wu Weibo , Li Yinfeng , Chen Li , Chen Chuming , Cao Mengli , Peng Ling , Jiang Xiao , Zhang Peiyan , Li Jianming , Yang Liuqing , Liu Yingxia , Liu Lei , Yang Liang , Wang Fuxiang 
Published: July 2020

Abstract
Background: This study aims to analyze the changes and significance of organ function indices in patients with severe Coronavirus Disease 2019 (COVID-19) pneumonia for prediction of major organ damages and guiding treatment schemes. Methods: 63 patients with severe COVID-19 pneumonia were selected as the severe group and 73 patients with mild syndromes were selected as the mild group. SAS9.4 software was used for statistical analysis of the data. Results: Levels of ALT, AST, cTnI, Cr, PT, APTT and D-DIC of the severe group were significantly higher while PLT was lower than those of the mild group. The data of all quantitative variables were converted into categorical variables. Significantly higher levels of AST, ALB, D-DIC and higher proportion of bilateral lung involvement were observed from the severe group comparing to those in the mild group, while the difference in the other indices between the two groups was insignificant in statistical perspective. Conclusions: There are significant differences in the levels of multiple organ function indices between the severe group and the mild group of patients with COVID-19 pneumonia infection. Through examining the relevant indices, conditions of patients’ multiple organ function damage could be predicted and used as guidance of treatment.
Tracheal Solid Variant of Adenoid Cystic Carcinoma with Basaloid Features: A Case Report and Review of Literature
Authors: Gao Feng , Zang Lijuan , He Jin , Xu Weiqing 
Published: July 2020

Abstract
Background: Primary tracheal adenoid cystic carcinoma (ACC) is a rare and heterogeneous group of neoplasms arising from the respiratory tract. The solid variant of ACC is a histologically distinct subtype with unfavorable clinical course. We report a case of tracheal ACC with immunohistochemical and molecular analysis together with a review of the literature. Case presentation: A 31-year-old man presented with a neoplasm growing on the lower part of the total tracheal membrane, left side wall and anterior wall. The tumor was obtained via fiberoptic bronchoscopy. Histologically, the tumor is characterized by a predominant compact sheet-like and nested pattern of rounded basaloid cells. Immunohistochemically, the tumor was diffusely positive for CK and CD117. CK7 and CK5/6 was focally positive in the genuine glandular structures. P63 was completely negative in majority of neoplastic cells. Fluorescence in situ hybridization analysis revealed MYB gene rearrangement. The current case showed an almost entirely solid pattern of growth with basaloid features, and was morphologically difficult to distinguish from a variety of other round cell neoplasms. Conclusions: This case report highlights the significance of various histological patterns and diagnostic modalities in making an accurate diagnosis of primary tracheal ACC at an early stage.
Face to Face with COVID-19: Highlights of Challenges Encountered in Various ENT Practices Across the Czech Republic (A National Survey)
Authors: Guha Anasuya , Plzak Jan , Chovanec Martin 
Published: July 2020

Abstract
The SARS-CoV-2 virus causing the COVID-19 disease created considerable complications and disruptions due to it’s pandemic spread. The nature of the disease left certain clinical specialties more vulnerable than others, causing serious problems with organization of care of patients. Most studies concentrated on protocols and strategies to control the situation and reduce further spread amongst medical fields. Only few were designed to identify the various issues faced by doctors. We decided to design a questionnaire addressing relevant matters for doctors working in the field of ear, nose and throat (ENT). This was then sent to all the members of the Czech Association of Otorhinolaryngologists. All ENT doctors were invited to fill out the survey within a stipulated time. The aim of the study was to evaluate the impact of a pandemic situation amongst such a high risk specialty. Our results showed a significant difference between the first cases of COVID-19 and progress of the disease during April 2020 in terms of workplace preparation, adequacy of personal protective equipment and other disposable aids. There was also inadequate support of medical personnel within the ENT practices. Furthermore, financial losses were also experienced due to mainly patient-related problems. In conclusion, the obtained results were used to formulate some recommendations for the public, patients, medical staff and employers. These suggestions will hopefully help avoid a repetition of the glitches if faced with another pandemic situation.