bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional and functional properties of cookies made using down‐graded lentil – A candidate for novel food production and crop utilization
Authors: Portman Drew , Maharjan Pankaj , McDonald Linda , Laskovska Slavica , Walker Cassandra , Irvin Heidi , Blanchard Chris , Naiker Mani , Panozzo Joe F. 
Published: October 2019

AbstractBackground and objectivesLentil (Lens culinaris M.) is a high‐value grain used traditionally as a minimally processed product. Lentil crops are well‐suited to Mediterranean‐type climates with mild winters and hot dry summers which results in the production of high‐value grain. However, extreme weather conditions, such as frost, can impact the lentil seed, for example, a darkened seed color and distorted seed shape resulting in a downgrade of its market value. The quality parameters of lentil when milled as wholemeal flour is not reliant on visual or physical seed traits such as seed size and color which impact on the market value in traditional market specifications. Instead, quality parameters such as those applied in the assessment of wheat, these include flour yield and color would be appropriate parameters to determine the value of lentil flour. It is proposed that flour, even from down‐graded lentil could be supplemented with wheat flour and used to enhance the quality profile of baked products including breads, pastas, and cookies.FindingsThis study investigated the use of premium and frost‐damaged lentil flour in cookie making. Overall cookies made from wheat–lentil composite blends resulted in flatter and wider cookies that were darker than the cookies made from 100% wheat flour. Cookies made by incorporating lentil and wheat flour resulted in a significant increase in total protein, insoluble fiber, and oligosaccharides (p < .05). In addition, the phenolic acids kaempferol and procyanidin were detected in cookies made using wheat–lentil contributing to an increase in antioxidant activity (p < .05). These phenolic acids were not detected in cookies made from 100% wheat flour. Our results show that using concentrations of up to 25% lentil flour resulted in cookies that had expectable hardness and color characteristics in comparison with a 100% wheat biscuit.ConclusionThis research showed that the nutritional value and functional properties of cookies can be significantly enhanced by using either premium or down‐graded lentil and the quality of the cookies was not impacted by the market‐grade of the raw material.Significance and noveltyInvestigations into the use of pulse flours such as lentil in novel food products including pasta and snack foods are gaining popularity particularly by the health‐conscious consumer. The visual appearance of lentil is not critical when utilized in such products. Lentil that has been visually or physically affected by adverse weather conditions, but its nutritional and functional values have not been compromised may prove a viable inclusion in the creation of highly nutritious food alternatives. The use of down‐graded lentil as flour in novel food production could ultimately add value to pulse grain affected by adverse environmental conditions.
Pharmacokinetic Similarity of ABP 710, a Proposed Biosimilar to Infliximab: Results From a Randomized, Single‐Blind, Single‐Dose, Parallel‐Group Study in Healthy Subjects
Authors: Chow Vincent , Oh MyungShin , Gessner Melissa A. , Fanjiang Gary 
Published: October 2019

AbstractThis was a randomized, single‐blind, single‐dose, 3‐arm parallel‐group study. Healthy subjects were randomized to receive ABP 710 (n = 50) or infliximab reference product (RP) sourced from the United States (infliximab US; n = 50) or the European Union (infliximab EU; n = 50) 5 mg/kg intravenously over 2 hours. The primary endpoint was area under the serum concentration–time curve from time 0 extrapolated to infinity (AUCinf) for the comparison of ABP 710 to infliximab US and infliximab EU. Secondary endpoints included safety, tolerability, and immunogenicity. AUCinf was similar across the 3 groups, showing similarity of ABP 710 to infliximab RP as well as similarity of infliximab US with infliximab EU. Geometric mean ratio of AUCinf was 0.89 between ABP 710 and infliximab US, 1.00 between ABP 710 and infliximab EU, and 1.11 between infliximab US and infliximab EU. All 90% confidence intervals of the geometric mean ratios were fully contained within the prespecified standard pharmacokinetic equivalence criteria range of 0.80 to 1.25. Treatment‐related adverse events were mild to moderate and reported for 83.7%, 86.0%, and 83.7% of subjects in the ABP 710, infliximab US, and infliximab EU treatment groups, respectively; incidence of antidrug antibody rates observed across the 3 groups were similar. Results of this study demonstrated pharmacokinetic similarity of ABP 710 with infliximab RP following a single 5‐mg/kg intravenous injection. The safety and tolerability of ABP 710 and infliximab RP were comparable. These results add to the totality of evidence providing further support that the proposed biosimilar ABP 710 is similar to infliximab RP. (Trial ID: ACTRN12614000903684.)
Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs
Authors: Mori Daiki , Kimoto Emi , Rago Brian , Kondo Yusuke , King‐Ahmad Amanda , Ramanathan Ragu , Wood Linda S. , Johnson Jillian G. , Le Vu H. , Vourvahis Manoli , David Rodrigues A. , Muto Chieko , Furihata Kenichi , Sugiyama Yuichi , Kusuhara Hiroyuki 
Published: October 2019

To address the most appropriate endogenous biomarker for drug–drug interaction risk assessment, eight healthy subjects received an organic anion transporting polypeptide 1B (OATP1B) inhibitor (rifampicin, 150, 300, and 600 mg), and a probe drug cocktail (atorvastatin, pitavastatin, rosuvastatin, and valsartan). In addition to coproporphyrin I, a widely studied OATP1B biomarker, we identified at least 4 out of 28 compounds (direct bilirubin, glycochenodeoxycholate‐3‐glucuronide, glycochenodeoxycholate‐3‐sulfate, and hexadecanedioate) that presented good sensitivity and dynamic range in terms of the rifampicin dose‐dependent change in area under the plasma concentration‐time curve ratio (AUCR). Their suitability as OATP1B biomarkers was also supported by the good correlation of AUC0‐24h between the endogenous compounds and the probe drugs, and by nonlinear regression analysis (AUCR−1 vs. rifampicin plasma Cmax (maximum total concentration in plasma)) to yield an estimate of the inhibition constant of rifampicin. These endogenous substrates can complement existing OATP1B‐mediated drug–drug interaction risk assessment approaches based on agency guidelines in early clinical trials.
Single Therapeutic and Supratherapeutic Doses of Ubrogepant Do Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized Trial
Authors: Jakate Abhijeet , Boinpally Ramesh , Butler Matthew , Lu Kaifeng , McGeeney Danielle , Periclou Antonia 
Published: October 2019

Ubrogepant is a novel, oral calcitonin gene–related peptide receptor antagonist currently under US Food and Drug Administration (FDA) review for the acute treatment of migraine attacks. This double‐blind, four‐period crossover study compared the cardiac repolarization effect of therapeutic (100 mg) and supratherapeutic (400 mg) ubrogepant doses vs. placebo in healthy adults. Moxifloxacin 400 mg was used as an open‐label active control, and the primary end point was change from baseline in Fridericia‐corrected QT intervals (ΔQTcF). Assay sensitivity was demonstrated via statistically significant QTcF prolongation with moxifloxacin vs. placebo. After single oral doses of ubrogepant, the least squares mean placebo‐corrected ΔQTcF (ΔΔQTcF) and 90% confidence intervals (CIs) did not exceed the 10‐millisecond regulatory threshold at any timepoint. The 90% CI upper bounds were 2.46 milliseconds and 2.69 milliseconds for ubrogepant 100 and 400 mg, respectively. Categorical and concentration‐based analyses were consistent with the primary result, showing no significant impact of ubrogepant on cardiac repolarization.
Si@SnS2–Reduced Graphene Oxide Composite Anodes for High‐Capacity Lithium‐Ion Batteries
Authors: Dai Jinyan , Liao Jiang , He Minyi , Yang Mengmeng , Wu Kaipeng , Yao Weitang 
Published: October 2019

AbstractOne of the key challenges for the development of lithium‐ion batteries is the preparation of high‐performance anode materials. In this paper, a micro/nanostructured Si@SnS2‐rGO composite is reported in which Si nanoparticles with a particle size of 30 nm are electrostatically anchored on a 3D reduced graphene oxide (rGO) network and mixed with SnS2. The step‐wise lithiation/delithiation of SnS2 provided space‐constraining effects to accommodate volume expansion and particle aggregation, thereby alleviating the volume expansion of Si during cycling as well as enhancing the structural stability, whereas the rGO in the 3D network stabilized the composite. The composite had a high specific capacity of 1480.1 mAh g−1 after 200 cycles at a current density of 200 mA g−1 and a high stability at rates of 200–3000 mA g−1. The capacity attenuation after cycling was only 89.18 %. A stable specific capacity (425.5 mAh g−1) was achieved after 600 cycles at a current density of 3000 mA g−1. Therefore, the micro/nanostructured Si@SnS2‐rGO composite is a promising anode material for use in lithium‐ion batteries.
Cooperation as a solution to shared resources in territorial use rights in fisheries
Authors: Aceves‐Bueno Eréndira , Miller Steve J. , Cornejo‐Donoso Jorge , Gaines Steven D. 
Published: October 2019

AbstractTerritorial use rights in fisheries (TURFs) are coastal territories assigned to fishermen for the exclusive extraction of marine resources. Recent evidence shows that the incentives that arise from these systems can improve fisheries sustainability. Although research on TURFs has increased in recent years, important questions regarding the social and ecological dynamics underlying their success remain largely unanswered. In particular, in order to create new successful TURFs, it is critical to comprehend how fish movement over different distances affects the development of sustainable fishing practices within a TURF. In theory, excessive spillover outside a TURF will generate incentives to overharvest. However, many TURFs have proven successful even when targeted species move over distances far greater than the TURF's size. A common attribute among some of these successful systems is the presence of inter‐TURF cooperation arrangements. This raises the question of how different levels and types of cooperation affect the motivations for overharvesting driven by the movement of fish outside the TURF. In this paper, we examine equilibrium yields under different levels of inter‐TURF cooperation (from partial to full) and varying degrees of asymmetry across TURFs of both biological capacity and benefit‐sharing. We find that partial cooperation can improve yields even with an unequal distribution of shared benefits and asymmetric carrying capacity. However, cooperation arrangements are unstable if the sharing agreement and biological asymmetries are misaligned. Remarkably, we find that asymmetry in the system can lead to the creation of voluntary no‐take zones.
Site‐specific responses of foliar fungal microbiomes to nutrient addition and herbivory at different spatial scales
Authors: Lumibao Candice Y. , Borer Elizabeth T. , Condon Bradford , Kinkel Linda , May Georgiana , Seabloom Eric W. 
Published: October 2019

AbstractThe plant microbiome can affect host function in many ways and characterizing the ecological factors that shape endophytic (microbes living inside host plant tissues) community diversity is a key step in understanding the impacts of environmental change on these communities. Phylogenetic relatedness among members of a community offers a way of quantifying phylogenetic diversity of a community and can provide insight into the ecological factors that shape endophyte microbiomes. We examined the effects of experimental nutrient addition and herbivory exclusion on the phylogenetic diversity of foliar fungal endophyte communities of the grass speciesAndropogon gerardiiat four sites in the Great Plains of the central USA. Using amplicon sequencing, we characterized the effects of fertilization and herbivory on fungal community phylogenetic diversity at spatial scales that spanned within‐host to between sites across the Great Plains. Despite increasing fungal diversity and richness, at larger spatial scales, fungal microbiomes were composed of taxa showing random phylogenetic associations. Phylogenetic diversity did not differ systematically when summed across increasing spatial scales from a few meters within plots to hundreds of kilometers among sites. We observed substantial shifts in composition across sites, demonstrating distinct but similarly diverse fungal communities were maintained within sites across the region. In contrast, at the scale of within leaves, fungal communities tended to be comprised of closely related taxa regardless of the environment, but there were no shifts in phylogenetic composition among communities. We also found that nutrient addition (fertilization) and herbivory have varying effects at different sites. These results suggest that the direction and magnitude of the outcomes of environmental modifications likely depend on the spatial scale considered, and can also be constrained by regional site differences in microbial diversity and composition.
On the immune response to barley in celiac disease: Biased and public T‐cell receptor usage to a barley unique and immunodominant gluten epitope
Authors: Dahal‐Koirala Shiva , Neumann Ralf S. , Jahnsen Jørgen , Lundin Knut E.A. , Sollid Ludvig M. 
Published: October 2019

AbstractCeliac disease (CeD) is driven by CD4+ T‐cell responses to dietary gluten proteins of wheat, barley, and rye when deamidated gluten epitopes are presented by certain disease‐associated HLA‐DQ allotypes. About 90% of the CeD patients express HLA‐DQ2.5. In such patients, five gluten epitopes dominate the anti‐gluten T‐cell response; two epitopes unique to wheat, two epitopes present in wheat, barley, and rye and one epitope unique to barley. Despite presence of barley in commonly consumed food and beverages and hence being a prominent source of gluten, knowledge about T‐cell responses elicited by barley in CeD is scarce. Therefore, in this study, we explored T‐cell response toward the barley unique epitope DQ2.5‐hor‐3 (PIPEQPQPY) by undertaking HLA‐DQ:gluten peptide tetramer staining, single‐cell T‐cell receptor (TCR) αβ sequencing, T‐cell cloning, and T‐cell proliferation studies. We demonstrate that majority of the CeD patients generate T‐cell response to DQ2.5‐hor‐3, and this response is characterized by clonal expansion, preferential TCR V‐gene usage and public TCR features thus echoing findings previously made for wheat gluten epitopes. The knowledge that biased and public TCRs underpin the T‐cell response to all the immunodominant gluten epitopes in CeD suggests that such T cells are promising diagnostic and therapeutic targets.
Too great to act in solidarity: The negative relationship between collective narcissism and solidarity‐based collective action
Authors: Górska Paulina , Stefaniak Anna , Malinowska Katarzyna , Lipowska Katarzyna , Marchlewska Marta , Budziszewska Magdalena , Maciantowicz Oliwia 
Published: October 2019

AbstractThree studies examined the association between narcissistic identification with one’s advantaged in‐group and engagement in solidarity‐based collective action. Drawing on theory and past research, a negative effect of collective narcissism on solidarity‐based collective action was expected. A two‐wave longitudinal study (N = 162) found that Polish participants’ narcissistic, but not secure, national identification decreased their willingness to engage in collective action in solidarity with refugees over time. A field study (N = 258) performed during a mass protest against a proposed abortion ban showed that men’s gender‐based collective narcissism was a negative predictor of solidarity‐based engagement (operationalized as protest behavior and collective action intentions) and this effect was mediated by lowered empathy for women. Finally, a web‐based survey (N = 1,992) revealed that heterosexual/cisgender individuals’ collective narcissism was negatively associated with collective action intentions in support of LGBT rights and that this effect was sequentially mediated by increased intergroup anxiety and decreased empathy for LGBT people. Theoretical implications of the present findings, research limitations, and future directions are discussed.
Application of Industry 4.0 to enhance sustainable manufacturing
Authors: Jena Madhab C. , Mishra Sarat K. , Moharana Himanshu S. 
Published: October 2019

AbstractThe proliferation of cyber‐physical systems introduces the fourth stage of industrialization, commonly known as Industry 4.0. There are many framework and researches have been conducted to implement the concept of Industry 4.0 in a customized way for different manufacturing and service requirements. In this article, a smart factory framework is presented by vertical integration of various components that incorporates industrial network, cloud, and supervisory control terminals with different functions, such as production, maintenance, energy consumption, water consumption, and so on, in a factory for optimizing resource utilization and eliminating all type wastages to enhance sustainable manufacturing. Moreover, this kind of self‐organized system enables the factory to achieve higher efficiency, minimized negative environmental impacts and improvements in other key performance indicators. To evaluate the outcome of this model implementation, a case study has been conducted on a cement plant where it is evident that after implementation of this model of sustainable manufacturing system the key environmental performance indicators such as specific energy consumption, carbon footprint, specific water consumption was reduced. It is observed that after implementing the sustainable manufacturing techniques, there is a substantial improvement in various performance indicators, those are, production volume of the factory was increased by 13.24%, process waste percentage came down by 12.79%, OEE improved by 12.94%. The major environmental performance parameters like specific energy consumption came down by 9.33%, specific carbon foot print came down by 9.33% and specific water consumption came down by 3.12% after implementing the sustainable manufacturing model.
Comparison of the increase in methane yield using alkali pretreatment for French weed and water lettuce prior to co‐digestion
Authors: Sinbuathong Nusara , Sombat Netechanok , Meksumpun Shettapong 
Published: October 2019

AbstractCo‐digestion with cow dung was undertaken of French weed (a recalcitrant weed) and water lettuce (a spongy weed). Untreated and pretreated weeds were co‐digested separately with cow dung to compare the increase in the methane (CH4) yield. The ratio of weed‐to‐cow dung‐to‐water of 10:10:80 was initially prepared. The pretreatment of weeds was performed using 1% sodium hydroxide for 24 hr at 30°C. Both weeds had the potential to produce biogas. The pretreatment increased the CH4 yield for both weeds but differently. The increase in the CH4 yield from co‐digestion of the pretreated French weed was clearly greater than for the pretreated water lettuce. Pretreatment increased the CH4 yield obtained from co‐digestion of French weed from 174 to 209 L/kg chemical oxygen demand (COD) degraded. However, the yields of the untreated and pretreated water lettuce were comparable at 209 and 210 L/kg COD degraded, respectively. Thus, a recalcitrant weed such as French weed was worth pretreating prior to co‐digestion but not a spongy weed such as water lettuce.
Utilization of oil recovered from biodiesel wastewater as an alternative feedstock for biodiesel production
Authors: Nikhom Ruamporn , Mueanmas Chokchai , Suppalakpanya Kittiphoom , Tongurai Chakrit 
Published: October 2019

AbstractBiodiesel is a renewable fuel commonly used to replace diesel. Currently, biodiesel production is controversial in food security circles because edible oils are used as biodiesel feedstock. This study investigates the use of nonedible oil, recovered from biodiesel wastewater (BWW), as an alternative feedstock for biodiesel production. BWW was treated with acidification with H2SO4 to recover the oil phase from the water. The major components of the recovered oil, 56.9 wt% ester and 38.1 wt% free fatty acids (FFA), demonstrated its potential as a feedstock for biodiesel production by esterification. The optimal conditions for biodiesel production from the recovered oil were 5 wt% H2SO4, a 2:1 M ratio of ethanol to FFA, a reaction temperature of 70°C, and a reaction time of 120 min. These conditions produced biodiesel with a purity of 97.7 wt% and a yield of 98.5 wt%. Additionally, the oil recovery process greatly reduced the pollutant load in BWW, bringing the cost of treatment below the usual cost of treating BWW with a high content of organic matter.
Preparation of activated carbon from water hyacinth stems by chemical activation with K2CO3 and its performance as adsorbent of sodium naproxen
Authors: González‐García P. , Gamboa‐González Sheila , Andrade Martínez Irving , Hernández‐Quiroz Teresa 
Published: October 2019

AbstractActivated carbons were obtained from water hyacinth stems using K2CO3 as activation agent, varying the impregnation time and the activation temperature and time, accordingly to a 23 factorial experimental design. The produced carbons showed activation yields (8–20%), alkaline point of zero charge (average of 9.5), methylene blue indexes from 264 to 893 m2/g, carboxylic surface groups in major proportion and graphitization degree from 4.01 to 6.27%. According to the statistical analysis, the activation temperature was significant for the yield and the methylene blue index. Activated carbon, labeled as AC5, was selected to assessing the naproxen adsorption in aqueous solution. Batch experiments yielded maximum adsorption capacity of 77.44% at pH ≈ 10.3, and contact time of 8 hr at initial concentration of 40 mg/g. The adsorption kinetics, isotherm model, and diffusion mechanism were described by the pseudo‐second order model, the Redlich‐Peterson equation and the film diffusion, respectively.
Study on the effects of the surface temperature on the formation of ammonium chloride and fly ash deposits
Authors: Zhou Hao , Chen Zhenhuan , Bai Zixian 
Published: October 2019

AbstractThe selective catalytic reduction technology has the potential hazards of NH3 escape while catalytically reducing NOx. The HCl in the flue gas can react with the NH3 under certain conditions to form NH4Cl and deposit in the appropriate temperature range. In this study, the deposition behavior of fly ash and NH4Cl was studied by a charge‐coupled device (CCD) camera in a drop tube furnace under the condition of the NH4Cl atmosphere. To investigate the effect of surface temperature on the deposition characteristics, we set the surface temperature at 363 K for Case 1, 373 K for Case 2, and 383 K for Case 3, respectively. The CCD camera monitored the morphology of ash deposit growth, and two type‐K thermocouples measured the temperature of the inner and outer surfaces of the deposition probe. Collected deposit samples were analyzed by scanning electron microscopy and X‐ray diffraction. The results showed that the primary substance of the deposited sediments was salammoniac (NH4Cl). The crystal granules of NH4Cl in the deposited sediment were disconnected, and they were denser under the lower surface temperatures. The deposited layer caused a declination in the heat flux through the deposition probe, and the lower surface temperature was more conducive to the growth of the deposition. This work contributes to a deeper understanding of the characteristics of NH4Cl deposition, which has practical utility in preventing the formation of the NH4Cl deposition in the precipitator and induced draft fans.