bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secrecy Sum Rate Maximization of RIS Assisted Downlink NOMA System
Authors: Liu Zhitao , Peng Yongkang , Li Youming , Du Yongfeng 
Published: February 2025

AbstractIn this paper, a method is proposed to improve the strongest user's channel gain and thus enhance the system secrecy sum rate (SSR) of the Non‐orthogonal multiple access (NOMA) system using a reconfigurable intelligent surface (RIS). Based on the observation that the decoding process of NOMA system utilizes the power allocation differences among multiple users and the SSR largely depends on the strongest user's channel gain, an optimal power allocation optimization problem is constructed under quality of service (QoS) and total power constraints. Then a low‐complexity relaxation based algorithm is proposed to improve the channel gain of the strongest user by optimizing the RIS phase, thereby enhancing the SSR of the system. The final simulation results show that the proposed method not only maintains good performance but also reduces computational complexity by about 2 dB.
Prediction of alcohol intake patterns with olfactory and gustatory brain connectivity networks
Authors: Agarwal Khushbu , Chaudhary Shefali , Tomasi Dardo , Volkow Nora D. , Joseph Paule V. 
Published: February 2025

Abstract
Craving in alcohol drinkers is often triggered by chemosensory cues, such as taste and smell, which are linked to brain network connectivity. This study aimed to investigate whether these brain connectivity patterns could predict alcohol intake in young adults. Resting-state fMRI data were obtained from the Human Connectome Project (HCP) Young Adult cohort, comprising 1003 participants. Functional connectomes generated from 100 independent components were analyzed, identifying significant connections correlated with taste and odor scores after applying a false discovery rate (FDR) correction using the Benjamini-Hochberg (BH) method. These significant connections were then utilized as predictors in general linear models for various alcohol intake metrics. The models were validated in an independent sample to assess their accuracy. The training sample (n = 702) and the validation sample (n = 117) showed no significant demographic differences. Out of 742 possible connections, 41 related to odor and 25 related to taste passed the significance threshold (P < 0.05) after FDR-BH correction. Notable predictors included visual-visual connectivity (node32-node13: β = 0.028, P = 0.02) for wine consumption and connectivity between the ventral attention network (VAN) and the frontal parietal/caudate nucleus (FP/CN) (node27-node9: β = −0.31, P = 0.04) for total alcohol intake in the past-week and maximum number of drinks per day in the past-year. The predictive models demonstrated strong accuracy, with root mean square error (RMSE) values of 5.15 for odor-related models and 5.14 for taste-related models. The F1 scores were 0.74 for the odor model and 0.71 for the taste model, indicating reliable performance. These findings suggest that specific patterns of brain connectivity associated with taste and olfactory perception may serve as predictors of alcohol consumption behaviors in young adults. Our study highlight the need for longitudinal research to evaluate the potential of taste- and smell-related brain connectivity patterns for early screening and targeted interventions, as well as their role in personalized treatment strategies for individuals at risk of AUD.
MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker
Authors: Wang Haibo , Chen Yibin , Yang Ying , Song Ran , Gu Siyu , Cao Xuedi , Zhang Lijie , Yang Yang , Hou Tianzhong , Qi Xuan , Yang Yumeng , Wang Yue , Bai Tao , Feng Duiping , Yang Xiaomei , He Junqi 
Published: February 2025

Abstract
Clear cell renal cell carcinoma (ccRCC) exhibits considerable heterogeneity, with approximately 25% of localized cases susceptible to relapse, highlighting the challenge of the absence of reliable predictive biomarkers for personalized treatment. Meanwhile, metastatic renal cell carcinoma is characterized by unfavorable survival rates, and although Sunitinib offers partial benefits, the clinical advantages are often constrained by drug resistance and adverse side effects. Here, MAGI3 was associate with ccRCC progression, as identified through comprehensive bioinformatics analysis of clinical datasets. A low level of MAGI3 emerged as a high-risk factor for ccRCC, indicating its potential as a prognostic marker. Individuals with MAGI3 expression in middle-to-low levels displayed a significantly poorer survival rate, indicating a need for additional treatment even in the early stages of ccRCC. Furthermore, patients with MAGI3 expression in middle-to-high levels exhibited increased sensitivity to Sunitinib compared to those with lower MAGI3 levels, suggesting that individuals with MAGI3 expression at middle levels may potentially benefit from Sunitinib treatment even in the early stages of ccRCC. Through its interaction with the MAS receptor, MAGI3 has been identified as a regulator of cell proliferation and a determinant of Sunitinib resistance in ccRCC, operating via the Ang-(1-7)/MAS/ERK axis. The loss of MAGI3 expression in ccRCC patients activated the ERK signaling pathway, contributing to both cancer progression and Sunitinib resistance. Therefore, our study not only highlight MAGI3’s pivotal role in ccRCC progression and Sunitinib resistance, but also reinforces MAGI3’s prospective value as a predictive marker.
An observational study of pleiotropy and penetrance of amyotrophic lateral sclerosis associated with CAG-repeat expansion of ATXN2
Authors: Demaegd Koen C. , Kernan Aoife , Cooper-Knock Johnathan , van Vugt Joke J. F. A. , Harvey Calum , Moll Tobias , O’Brien David , Gornall Sarah , Drury Luke , Farhan Sali M. K. , Dion Patrick A. , Rouleau Guy A. , Western Andrea , Parsons Paul J. , Mclean Benjamin , Benatar Michael , van den Berg Leonard H. , Van Damme Philip , Willem Dankbaar Jan , Hendrikse Jeroen , Koole Wouter , de Bie Charlotte , Hobson Esther , Veldink Jan H. , van de Warrenburg Bart , Pasterkamp R. Jeroen , van Rheenen Wouter , Kirby Janine , Shaw Pamela J. , van Es Michael. A. 
Published: February 2025

Abstract
Spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS) are both associated with a CAG-repeat expansion in ATXN2 and with TDP-43-positive neuronal cytoplasmic inclusions. The two disorders have been viewed as distinct entities, where an intermediate length expansion of 31-33 CAG-repeats is associated with sporadic ALS and a full length expansion of ≥34 CAG-repeats is associated with SCA2. We report the clinical phenotype of ATXN2-positive patients and their relatives, identified in three specialist ALS clinics, which force a reconsideration of this dichotomy. We also report the frequency of ATXN2 expansions in two large cohorts of ALS patients and in a population-matched cohort of controls. We report ten cases of familial ALS in which disease is associated with either an intermediate or a full-length ATXN2 CAG-repeat expansion. Pedigrees and patients feature additional phenotypes including parkinsonism, dementia and essential tremor (ET). We conclude that CAG-repeat expansions in ATXN2 exhibit pleiotropy and are associated with a disease spectrum that includes ALS, SCA2, and parkinsonism; to recognise this complexity we propose the new term ‘ATXN2-related neurodegeneration’. We also observed sporadic ALS associated with full-length expansions. We conclude that ATXN2 CAG-repeat expansions, irrespective of length, should be considered a risk factor for ALS. Interrupted CAG-repeats were associated with an ALS phenotype in our data but we also identified ALS cases with uninterrupted expansions. Our findings have relevance for researchers, patients and families linked to CAG-repeat expansions in ATXN2.
Digital aberration correction for enhanced thick tissue imaging exploiting aberration matrix and tilt-tilt correlation from the optical memory effect
Authors: Oh ChulMin , Hugonnet Herve , Lee Moosung , Park YongKeun 
Published: February 2025

Abstract
Optical aberrations significantly impair microscopic image quality across various domains, including cell biology and histopathology diagnostics. Traditional adaptive optics techniques, such as wavefront shaping and guide star utilization, face challenges, especially in imaging biological tissues. Here, we introduce a computational adaptive optics approach tailored for optically thick samples. Utilizing the tilt-tilt correlation from the optical memory effect, our method detects phase differences in aberrations caused by small tilts in the incident waves. Experimental validation demonstrates our technique’s capacity to enhance imaging of thick human tissues under substantial aberration conditions using a transmission-mode holotomography setup. Remarkably, our approach works robustly against sample movement, which is essential for enhanced imaging accuracy in critical biomedical applications.
SRBD1 facilitates chromosome segregation by promoting topoisomerase IIα localization to mitotic chromosomes
Authors: Lovejoy Courtney A. , Wessel Sarah R. , Bhowmick Rahul , Hatoyama Yuki , Kanemaki Masato T. , Zhao Runxiang , Cortez David 
Published: February 2025

Abstract
Accurate sister chromatid segregation requires remodeling chromosome architecture, decatenation, and attachment to the mitotic spindle. Some of these events are initiated during S-phase, but they accelerate and conclude during mitosis. Here we describe SRBD1 as a histone and nucleic acid binding protein that prevents DNA damage in interphase cells, localizes to nascent DNA during replication and the chromosome scaffold in mitosis, and is required for chromosome segregation. SRBD1 inactivation causes micronuclei, chromatin bridges, and cell death. Inactivating SRBD1 immediately prior to mitotic entry causes anaphase failure, with a reduction in topoisomerase IIα localization to mitotic chromosomes and defects in properly condensing and decatenating chromosomes. In contrast, SRBD1 is not required to complete cell division after chromosomes are condensed. Strikingly, depleting condensin II reduces the severity of the anaphase defects in SRBD1-deficient cells by restoring topoisomerase IIα localization. Thus, SRBD1 is an essential genome maintenance protein required for mitotic chromosome organization and segregation.
Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity
Authors: Patel Tushar P. , Jun Joo Yun , Seo Arnold Y. , Levi Noah J. , Elizondo Diana M. , Chen Jocelyn , Wong Adrian M. , Tugarinov Nicol , Altman Elizabeth K. , Gehle Daniel B. , Jung Sun Min , Patel Pooja , Ericson Mark , Haskell-Luevano Carrie , Demby Tamar C. , Cougnoux Antony , Wolska Anna , Yanovski Jack A. 
Published: February 2025

Abstract
Systemic lipid homeostasis requires hepatic autophagy, a major cellular program for intracellular fat recycling. Here, we find melanocortin 3 receptor (MC3R) regulates hepatic autophagy in addition to its previously established CNS role in systemic energy partitioning and puberty. Mice with Mc3r deficiency develop obesity with hepatic triglyceride accumulation and disrupted hepatocellular autophagosome turnover. Mice with partially inactive human MC3R due to obesogenic variants demonstrate similar hepatic autophagic dysfunction. In vitro and in vivo activation of hepatic MC3R upregulates autophagy through LC3II activation, TFEB cytoplasmic-to-nuclear translocation, and subsequent downstream gene activation. MC3R-deficient hepatocytes had blunted autophagosome-lysosome docking and lipid droplet clearance. Finally, the liver-specific rescue of Mc3r was sufficient to restore hepatocellular autophagy, improve hepatocyte mitochondrial function and systemic energy expenditures, reduce adipose tissue lipid accumulation, and partially restore body weight in both male and female mice. We thus report a role for MC3R in regulating hepatic autophagy and systemic adiposity.
Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans
Authors: Zou Wenjuan , Fan Yuedan , Liu Jia , Cheng Hankui , Hong Huitao , Al-Sheikh Umar , Li Shitian , Zhu Linhui , Li Rong , He Longyuan , Tang Yi-Quan , Zhao Guohua , Zhang Yongming , Wang Feng , Zhan Renya , Zheng Xiujue , Kang Lijun 
Published: February 2025

Abstract
Mechanotransduction channels are widely expressed in both vertebrates and invertebrates, mediating various physiological processes such as touch, hearing and blood-pressure sensing. While previously known mechanotransduction channels in metazoans are primarily cation-selective, we identified Anoctamin-1 (ANOH-1), the C. elegans homolog of mammalian calcium-activated chloride channel ANO1/TMEM16A, as an essential component of a mechanosensory channel complex that contributes to the nose touch mechanosensation in C. elegans. Ectopic expression of either C. elegans or human Anoctamin-1 confers mechanosensitivity to touch-insensitive neurons, suggesting a cell-autonomous role of ANOH-1/ANO1 in mechanotransduction. Additionally, we demonstrated that the mechanosensory function of ANOH-1/ANO1 relies on CIB (calcium- and integrin- binding) proteins. Thus, our results reveal an evolutionarily conserved chloride channel involved in mechanosensory transduction in metazoans, highlighting the importance of anion channels in mechanosensory processes.
Structural insights into the in situ assembly of clustered protocadherin γB4
Authors: Zhang Ze , Chen Fabao , Zhang Zihan , Guo Luqiang , Feng Tingting , Fang Zhen , Xin Lihui , Yu Yang , Hu Hongyu , Liu Yingbin , He Yongning 
Published: February 2025

Abstract
Clustered protocadherins (cPcdhs) belong to the cadherin superfamily and play important roles in neural development. cPcdhs mediate homophilic adhesion and lead to self-avoidance and tiling by giving neurons specific identities in vertebrates. Structures and functions of cPcdhs have been studied extensively in past decades, but the mechanisms behind have not been fully understood. Here we investigate the in situ assembly of cPcdh-γB4, a member in the γ subfamily of cPcdhs, by electron tomography and find that the full length cPcdh-γB4 does not show regular organization at the adhesion interfaces. By contrast, cPcdh-γB4 lacking the intracellular domain can generate an ordered zigzag pattern between cells and the cis-interacting mode is different from the crystal packing of the ectodomain. We also identify the residues on the ectodomain that might be important for the zigzag pattern formation by mutagenesis. Furthermore, truncation mutants of the intracellular domain reveal different assembly patterns between cell membranes, suggesting that the intracellular domain plays a crucial role in the intermembrane organization of cPcdh-γB4. Taken together, these results suggest that both ectodomain and intracellular domain regulate the in situ assembly of cPcdh-γB4 for homophilic cell adhesion, thereby providing mechanistic insights into the functional roles of cPcdhs during neuronal wiring.
Chiral plasmonic superlattices from template-assisted assembly of achiral nanoparticles
Authors: Qi Xiaoyu , Pérez Luis Alberto , Mendoza-Carreño Jose , Garriga Miquel , Alonso Maria Isabel , Mihi Agustín 
Published: February 2025

Abstract
The creation of chiral plasmonic architectures combining templates with achiral plasmonic particles leads to strong chiroptical responses that can be finely tuned via the characteristics of the colloidal building blocks. Here we show how elastomeric molds, pre-patterned with a hexagonal array of triskelia motifs, can guide the assembly of ordinary noble metal colloids into chiral plasmonic architectures with strong dichroism values. Under normal incidence, the chiral arrays made with gold and silver colloids showed g-factors of 0.18 and 0.4, respectively. In all cases, increasing the size of the colloid allows tuning the optical properties of the structure in the VIS-NIR range. When a superstrate layer is deposited onto the structures, the extrinsic chirality response of the 2D superlattice is revealed and strongly amplified by the chiral motifs under oblique inspection, leading to g-factors of ± 1.2 at ± 14°. Finally, these chiral plasmonic resonances sustained by the triskelion array are used to produce circularly polarized photoluminescence from achiral organic dyes placed on top with up to 20% of dissymmetry.
Tissue factor-dependent colitogenic CD4+ T cell thrombogenicity is regulated by activated protein C signalling
Authors: Leon Gemma , Klavina Paula A. , Rehill Aisling M. , Cooper Sarah E. J. , Dominik Anna , Basavarajappa Shrikanth Chomanahalli , O’Donnell James S. , Hussey Seamus , Walsh Patrick T. , Preston Roger J. S. 
Published: February 2025

Abstract
Patients with inflammatory bowel disease (IBD) have an increased risk of venous thromboembolism (VTE), but the underlying mechanistic basis remains poorly defined. Here, we find that colitogenic CD4+ T cells express tissue factor (TF) and promote rapid TF-dependent plasma thrombin generation. TF+CD3+CD4+ T cells are present in both the colons of mice with experimental colitis and blood and colonic tissue from patients with IBD. Expression of genes involved in regulating coagulation, including Protein C (PC; encoded by PROC) and its receptor (PROCR), are dysregulated in IBD patient gut biopsy tissues. Moreover, activated PC signalling reduces the procoagulant activity mediated by TF+CD4+ T cells. Our data thus identify TF-induced, colitogenic T cell-mediated thrombogenicity, and also demonstrate a new function for activated PC signalling in regulating T cell thrombo-inflammatory activity.
Difunctionalization of bicyclo[1.1.0]butanes enabled by merging C−C cleavage and ruthenium-catalysed remote C−H activation
Authors: Chen Shan , Xu Zhimin , Yuan Binbin , Gou Xue-Ya , Ackermann Lutz 
Published: February 2025

Abstract
The high fraction of sp
3-hybridized carbon atom (Fsp
3) character of cyclobutane derivatives renders them as highly promising bioisosteres for otherwise typically flat arenes. Here, to address the current needs in medicinal chemistry for Fsp
3-rich molecules, we disclose a distinct strategy that exploits the merger of C–C scission in bicyclo[1.1.0]butanes (BCBs) with ruthenium-catalysed remote C−H functionalization of heteroarenes, affording densely substituted cyclobutanes in a chemo-controlled manner. This approach enabled the rapid and efficient synthesis of versatile tri- and tetrasubstituted cyclobutanes by coupling a wide range of mono- or disubstituted BCBs with heteroarenes and alkyl halides under mild reaction conditions, featuring ample substrate scope. The C–C/C–H functionalization was ensured by a multifunctional ruthenium(II) catalyst that enabled ruthenacycle-mediated halogen-atom transfer (Ru-XAT), as well as the selective functionalization of BCBs by strain release. Experimental and computational mechanistic studies unravelled a multi-catalysis manifold, while the C–H/C–C functionalization strategy allowed for telescoping late-stage modification.
Enhancing future HIV services through telehealth services: an observational study to explore telehealth adoption and usage for HIV prevention and treatment during the COVID-19 pandemic
Authors: Wong Chen Seong , Hashim Anwar , Park Sejun , Phanuphak Nittaya , Janamnuaysook Rena , Simpauco Edel Buna , Wong Timothy , Woo Amanda Rui En , Mo Billy , Green Kimberly 
Published: February 2025

Background Telehealth adoption for HIV care continuum accelerated during the COVID-19 pandemic. This study explored telehealth usage, motivators and barriers to telehealth adoption, and implementation challenges during the pandemic among people living with HIV, individuals at risk and community-based organisations (CBOs) in Asia. Methods This cross-sectional study was conducted in June to December 2022 using an online quantitative survey among people living with HIV (n = 787) and individuals at risk (n = 744), and semi-structured qualitative interviews with CBOs across nine countries/territories in Asia. Responses from the survey were reported descriptively, and narratives from the interviews were used to identify the main themes associated with engagement configurations by CBOs. Results Regionally, HIV-related telehealth services were used by 56.8% of people living with HIV and 66.5% of individuals at risk, with 53.6–55.9% increasing their usage in 2021. Phone consultations, HIV-related health information sharing and video communications were the most commonly accessed services by telehealth users. Telehealth users most trusted mobile applications or software provided by clinics/healthcare providers/local CBOs. Telehealth uptake motivators included saving travelling time, improved access to HIV prevention care services and information outside of medical appointments; barriers included data privacy concerns and lack of technology accessibility, which were similarly acknowledged by local CBOs. Lack of resources to support telehealth services, and local policies on HIV prevention and treatment impeded CBOs from adequately delivering HIV care through telehealth. Conclusions This study highlights the potential of telehealth in HIV care while identifying critical challenges for its sustained integration. Addressing these issues (e.g. data privacy, telehealth infrastructure) would be essential to optimise telehealth services and improve HIV outcomes in the region.
Optimization of LiDAR Scanning Positions in Tunnel Environments: Analyzing the Impact of Station Height and Lateral Deviation
Authors: Mingsong DAI , Jiang Jundi , Yun HAN , Yazhou DING , Junping LI , Qi TIAN , Shen Yueqian 
Published: February 2025

Abstract
Subway tunnels deteriorate over time, posing safety risks that necessitate regular inspections. Traditional methods, like manual surveys and total station measurements, are inefficient and provide sparse data. LiDAR technology overcomes these limitations by capturing dense 3D point clouds efficiently. However, its effectiveness is influenced by factors such as incidence angles, scanning distance, and point cloud density, all dependent on station placement. This study develops a model for straight and curved tunnels to analyze how station positioning affects point cloud quality. Results indicate that placing LiDAR stations lower and closer to tunnel walls maximizes coverage, with a maximum effective scanning length of 23.48 meters per station for a 2.75-meter radius tunnel. An alternating station setup further enhances efficiency and accuracy, minimizing station replacements. Validation using Nanjing subway tunnels confirms the effectiveness of the proposed approach in improving data collection and structural assessments, providing practical guidance for LiDAR-based inspections.