bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a superabsorbent wound dressing, patient and clinician perspective: a case series
Authors: Atkin Leanne , Barrett Simon , Chadwick Paul , Callaghan Rosie , Rippon Mark G , Rogers Alan A , Simm Sue 
Published: March 2020

Objective: The primary objective of this study was to evaluate the fluid management capabilities of a superabsorbent wound dressing (Zetuvit Plus Silicone), with secondary objectives related to parameters that support whether the dressing enables undisturbed healing. Method: This study was an open labelled non-comparative study. Patients included in the study were selected by the clinical investigator(s) according to whether the patient required a dressing for the management of moderately to highly exuding wounds. Results: A total of 50 patients were included in the study. Results related to the primary objective demonstrated that the superabsorbent wound dressing was able to absorb all levels of exudate across the range (low to high). At each assessment time point these results show that in 98% of assessments the superabsorbent dressing was rated as ‘very good’ (91%) or ‘good’ (7%) at exudate management. Secondary objectives relating to wound bed preparation, healing and management of pain were also positive. Additionally, at the end of each patient treatment, the dressing's fluid management capabilities were rated overall as ‘excellent’ (100% of cases). There was little pain associated with the wound or at dressing change throughout the study and its flexibility/conformability allowed for comfort and patient satisfaction aligned with increased quality of life. Additionally, inclusion of a silicone adhesive layer allowed painless and atraumatic removal of the dressing, increasing patient comfort, both during wear and at dressing removal, and supported the description of enabling undisturbed wound healing. Conclusion: The superabsorbent wound dressing achieved the primary objective relating to wound exudate management in all the assessments undertaken in this study. In addition, the silicone interface allowed for undisturbed healing as evidenced by little or no adherence of the dressing to underlying tissue, preventing damage to periwound skin. Overall, the superabsorbent wound dressing with the addition of the silicone interface could offer advantages over other superabsorbent polymer dressings (that might adhere to the wound surface) or silicone wound dressings (that might not have the absorbent properties of this type of dressing).
Punch grafting for pain reduction in hard-to-heal ulcers
Authors: Conde-Montero Elena , de Farias Khayat Yasmin , Pérez Jerónimo Laura , Vázquez Alicia Peral , Marín Lorena Recarte , Guisado Soledad , de la Cueva Dobao Pablo 
Published: March 2020

Objective:Punch-grafting is a traditional technique to enhance wound healing, which has been associated with significant pain reduction. There are few studies measuring pain reduction after punch grafting, our study was designed to measure this outcome.Method:Patients with hard-to-heal wounds treated with punch grafting were included in a single centre prospective study. Wound pain intensity was measured using a Visual Analogue Scale (VAS) at baseline (before the procedure) and at three time points after the procedure. Punch grafting was performed in an outpatient setting. Patient demographic data, wound aetiology and percentage of graft take were recorded.Results:A total of 136 patients were included (62 men and 74 women). Mean age was 60±35 years and 51 (38%) had venous leg ulcers (VLU), 29 (21%) had postoperative wounds, 15 (11%) Martorell ulcers, 15 (11%) traumatic wounds, four (3%) arterial ulcers and 22 ‘other’ ulcers. Of the patients, 31 (23%) did not present with painful ulcers and, after punch grafting, all of them remained painless; 16 (12%) patients obtained >70% pain reduction, whereas 86 (63%) patients achieved pain suppression. Pain suppression did not depend on the percentage of graft take.Conclusion:Punch-grafting is a simple, technique that not only promotes wound healing but also reduces pain. It can also be performed on an outpatient basis. Further studies should be performed to achieve a better understanding of this beneficial finding. Declaration of interest: The authors have no conflicts of interest to declare.
Prevalence of pressure ulcers in hospitalised patients: a cross-sectional study
Authors: Olivo Stella , Canova Cristina , Peghetti Angela , Rossi Maurilio , Zanotti Renzo 
Published: March 2020

Objective:The main aim of this study was to estimate the prevalence of pressure ulcers (PU) and related risk factors of PU development in hospitalised patients in Italy. Furthermore, the study investigated the association between risk factors for PU present on admission and the development during hospitalisation (hospital-acquired pressure ulcer, HAPU).Methods:A cross-sectional study, using two separate designs at two separate timepoints: 2010 and 2015. The methodology used to measure PU prevalence was that recommended by the European Pressure Ulcer Advisory Panel (EPUAP).Results:The total sample was 7681 hospitalised patients (3011 patients in 2010, 4670 in 2015). Prevalence of PU in hospital was 19.5% in 2010 and 17% in 2015. The number of patients with PU present on admission were 9.60% in 2010 and 9.42% in 2015. Patients with HAPU were 5.08% in 2010 and 5.87% in 2015. Older age and comorbidities, and a total Braden score of ≤16 were positively associated with PU present on admission and HAPU in hospitals (p<0.05). A longer length of stay appeared to correlate positively with a better clinical outcome for PU if there were already present on admission. Heterogeneous results emerged for length of stay of >30 days and being admitted to intensive care unit (ICU).Conclusion:Our results are comparable with other European and Italian studies. Most of the risk factors associated with PU development have been confirmed. However, further studies are needed to examine the effects of context on PU present on arrival and HAPU, especially regarding hospital length of stay.
Heterotopic ossification: a preventable case of gossypiboma in spinal cord injury
Authors: Liu Xiangxia , Kaminsky Alexander J , Hill David M , Velamuri Sai R 
Published: March 2020

Objective: Heterotopic ossification is the formation of ectopic bone in soft tissues. It has three established aetiologies: genetic, traumatic and neurogenic. A gossypiboma is defined as a retained foreign body, such as a mass or sponge, usually after a surgical procedure. In this article, we present a unique, preventable case of a patient admitted for newly developed heterotopic ossification in the gluteus maximus muscle caused by a retained piece of foam from negative pressure wound therapy (NPWT). The heterotopic ossification lesion, together with the retained foreign body, was completely excised and reconstructed using a posterior thigh fasciocutaneous advancement flap. This is the first reported case of heterotopic ossification caused by a retained foreign body and may be helpful to better understanding of the aetiology of heterotopic ossification.
La utilidad de lo efímero en el estudio de la lengua del siglo XIX: Cuestiones gramaticales a través de la prensa
Authors: Puche Lorenzo Miguel Ángel 
Published: March 2020

La prensa, durante el siglo XIX, se convierte en el medio idóneo para difundir y exponer las más diversas cuestiones. A causa del alcance social adquirido, es el texto escrito de mayor trascendencia de este periodo y en él adquiere especial protagonismo la lengua. Por ello, las opiniones vertidas, los debates planteados o la propagación de nuevos modelos lingüísticos aparecidos en sus páginas permiten destacar la utilidad de este medio efímero para la evolución de la lengua española, relativa a un periodo poco atendido. El análisis de determinadas cuestiones gramaticales será un claro ejemplo de su importancia y de que, probablemente, determinados cambios se propagaron o se dataron por vez primera en sus páginas.
A Facile and Catalyst-free Synthesis of Hexahydroacridine-1,8(2H,5H )-dione and Octahydroacridin-10(1H )-yl)thiourea Derivatives: Inter- and Intramolecular Aza-Michael addition
Authors: Pesyan Nader Noroozi , Akhteh Narmin , Batmani Hana , Anıl Barış , Şahin Ertan 
Published: March 2020

Abstract
An easy and convenient technique for the one-pot synthesis of novel compounds of hexahydroacridine-1,8(2H,5H)-dione and octahydroacridin-10(1H)-yl) thiourea derivatives has been developed by the reaction of the octahydro-1H-xanthenes with hydroxylamine hydrochloride and thiosemicarbazide in ethylene glycol, which is a green solvent, under mild reaction conditions. IR, 1H NMR, 13C NMR spectrometry, and X-ray diffraction analysis were used to identify the structures of these compounds.
Quercetin modulates granulosa cell mRNA androgen receptor gene expression in dehydroepiandrosterone-induced polycystic ovary in Wistar rats via metabolic and hormonal pathways
Authors: Olaniyan Olugbemi T. , Bamidele Okoli , Adetunji Charles O. , Priscilla Bretet , Femi Adebayo , Ayobami Dare , Okotie Gloria , Oluwaseun Ibitoye , Olugbenga Eweoya , Mali Pratap C. 
Published: March 2020

Abstract

Background
It is estimated that about 5–10% of women suffer from polycystic ovarian syndrome (PCOS) which is a major cause of female reproductive dysfunction. This study examined the role of quercetin on dehydroepiandrosterone (DHEA)-induced PCO in Wistar rats.

Methods
Twenty-eight pre-pubertal female Wistar rats that are 21 days old weighing 16–21 g were sorted into four groups (n = 7). Group I served as control and was given distilled water only, Group II were injected with 6 mg/100 g BW of DHEA in 0.2 mL of corn oil subcutaneously, Group III received 100 mg/kg BW of quercetin orally and Group IV received 6 mg/100 g BW of DHEA in 0.2 mL of corn oil subcutaneously and 100 mg/kg BW of quercetin orally. Rats were sacrificed after 15 days by cervical dislocation method. Blood samples and ovaries were collected for hormonal, biochemical, and histopathological analysis and expressions of mRNA androgen receptor gene were determined using RT–qPCR. All data were analysed using one-way ANOVA.

Results
A significant decrease (p < 0.05) in the antioxidant and metabolic enzyme activity in the DHEA treated group was observed when compared with control. DHEA co-administration with quercetin showed a significant decrease in malondialdehyde and cytokines when compared with DHEA treated group. Also a significant increase in progesterone, metabolic and antioxidant enzyme activity was observed. The histopathology demonstrates a reduction in cystic and atretic cells, improved expression of BCl2, E-Cadherin and a decrease in Bax.

Conclusions
Quercetin alleviated DHEA-induced PCO. These effects could be attributed to its antioxidant property.
The Ethics of Police Body-Worn Cameras
Authors: Thomsen Frej Klem 
Published: March 2020

AbstractOver the past decade, police departments in many countries have experimented with and increasingly adopted the use of police body-worn cameras (PBWCs). This article aims to examine the moral issues raised by the use of PBWCs, and to provide an overall assessment of the conditions under which the use of PBWCs is morally permissible. It first reviews the current evidence for the effects of using PBWCs. On the basis of this review the article sets out a teleological argument for the use of PBWCs. The final two sections of the article review two deontological objections to the use of PBWCs: the idea that use of PBWCs is based on or expresses disrespectful mistrust, and the idea that the use of PBWCs violates a right to privacy. The article argues that neither of these objections is persuasive, and concludes that we should conditionally accept and support the use of PBWCs.
Discovery of bioactive drug candidates from some Turkish medicinal plants-neuroprotective potential of Iris pseudacorus L.
Authors: Sener Bilge , Sevim Duygu 
Published: March 2020

Abstract
Medicinal plants have an enormous potential for producing bioactive compounds of great benefit to mankind. There is a great scope for new drug candidates based on traditional medicinal plants throughout the world. The number of drugs derived from medicinal plants that are recently introduced into clinical use is increasing. Besides, numerous of standardized herbal extracts were also approved as phytomedicines by the health authorities to be used in phytotherapy. The drug discovery program from nature in our laboratory involves several steps from plant collection, extraction, HTS of the extracts by using in vitro enzyme inhibitory tests, bioassay-guided fractionation through the isolation and structure elucidation of bioactive compounds. Continuing our researches in the field of anticholinesterase activity, neuroprotective potential of Iris pseudacorus L. have presented in this article.
Change of Direction Performance in Elite Players From Different Team Sports
Authors: Loturco Irineu , Pereira Lucas A. , Reis Valter P. , Abad César C. C. , Freitas Tomás T. , Azevedo Paulo H. S. M. , Nimphius Sophia 
Published: March 2020

Abstract
Loturco, I, Pereira, LA, Reis, VP, Abad, CCC, Freitas, TT, Azevedo, PHSM and Nimphius, S. Change of direction performance in elite players from different team sports. J Strength Cond Res 36(3): 862–866, 2022—The primary aim of this study was to examine the differences in change of direction (COD) deficit between elite futsal, soccer, handball, and rugby players. A secondary aim was to compare the performance in both COD and linear speed tests among these athletes. One-hundred sixty-one elite male players from 4 team sports performed a 20-m linear sprint speed and a Zigzag COD speed test. The COD deficit was calculated as the difference between linear and Zigzag test velocities. Differences in COD speed, COD deficit, and sprint velocity were assessed via 1-way analysis of variance. The significance level was set at p < 0.05. Soccer players displayed significantly lower performance than the remaining team sports, and rugby players performed better than all the other groups in the Zigzag COD test. Moreover, the COD deficit was significantly higher in soccer players in comparison with the other disciplines (p < 0.05). No differences were observed in the COD deficit among rugby, futsal, and handball players (p > 0.05). In summary, soccer players were slower than futsal, handball, and rugby players to change direction and presented the greatest COD deficit magnitude. By contrast, the fastest athletes in the COD speed test (rugby players) were not more effective than futsal and handball players at changing direction (as they exhibited similar levels of COD deficit). Coaches should be aware of this evidence, which reinforces previous findings, indicating that very specialized training strategies might be required to improve COD performance in professional athletes.
Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling
Authors: Liu Dai-Chi , Soriano Stephanie , Yook Yeeun , Lizarazo Simon , Eagleman Daphne E. , Tsai Nien-Pei 
Published: March 2020

AbstractGroup 1 metabotropic glutamate receptors (Gp1 mGluRs), including mGluR1 and mGluR5, are critical regulators for neuronal and synaptic plasticity. Dysregulated Gp1 mGluR signaling is observed with various neurologic disorders, including Alzheimer’s disease, Parkinson’s disease, epilepsy, and autism spectrum disorders (ASDs). It is well established that acute activation of Gp1 mGluRs leads to elevation of neuronal intrinsic excitability and long-term synaptic depression. However, it remains unknown how chronic activation of Gp1 mGluRs can affect neural activity and what molecular mechanisms might be involved. In the current study, we employed a multielectrode array (MEA) recording system to evaluate neural network activity of primary mouse cortical neuron cultures. We demonstrated that chronic activation of Gp1 mGluRs leads to elevation of spontaneous spike frequency while burst activity and cross-electrode synchronization are maintained at the baseline. We further showed that these neural network properties are achieved through proteasomal degradation of Akt that is dependent on the tumor suppressor p53. Genetically knocking down p53 disrupts the elevation of spontaneous spike frequency and alters the burst activity and cross-electrode synchronization following chronic activation of Gp1 mGluRs. Importantly, these deficits can be restored by pharmacologically inhibiting Akt to mimic inactivation of Akt mediated by p53. Together, our findings reveal the effects of chronic activation of Gp1 mGluRs on neural network activity and identify a unique signaling pathway involving p53 and Akt for these effects. Our data can provide insights into constitutively active Gp1 mGluR signaling observed in many neurologic and psychiatric disorders.
Pattern Separation Underpins Expectation-Modulated Memory
Authors: Frank Darya , Montemurro Marcelo A. , Montaldi Daniela 
Published: March 2020

Pattern separation and completion are fundamental hippocampal computations supporting memory encoding and retrieval. However, despite extensive exploration of these processes, it remains unclear whether and how top-down processes adaptively modulate the dynamics between these computations. Here we examine the role of expectation in shifting the hippocampus to perform pattern separation. In a behavioral task, 29 participants (7 males) learned a cue-object category contingency. Then, at encoding, one-third of the cues preceding the to-be-memorized objects, violated the studied rule. At test, participants performed a recognition task with old objects (targets) and a set of parametrically manipulated (very similar to dissimilar) foils for each object. Accuracy was found to be better for foils of high similarity to targets that were contextually unexpected at encoding compared with expected ones. Critically, there were no expectation-driven differences for targets and low similarity foils. To further explore these effects, we implemented a computational model of the hippocampus, performing the same task as the human participants. We used representational similarity analysis to examine how top-down expectation interacts with bottom-up perceptual input, in each layer. All subfields showed more dissimilar representations for unexpected items, with dentate gyrus (DG) and CA3 being more sensitive to expectation violation than CA1. Again, representational differences between expected and unexpected inputs were prominent for moderate to high levels of input similarity. This effect diminished when inputs from DG and CA3 into CA1 were lesioned. Overall, these novel findings strongly suggest that pattern separation in DG/CA3 underlies the effect that violation of expectation exerts on memory.SIGNIFICANCE STATEMENTWhat makes some events more memorable than others is a key question in cognitive neuroscience. Violation of expectation often leads to better memory performance, but the neural mechanism underlying this benefit remains elusive. In a behavioral study, we found that memory accuracy is enhanced selectively for unexpected highly similar foils, suggesting expectation violation does not enhance memory indiscriminately, but specifically aids the disambiguation of overlapping inputs. This is further supported by our subsequent investigation using a hippocampal computational model, revealing increased representational dissimilarity for unexpected highly similar foils in DG and CA3. These convergent results provide the first evidence that pattern separation plays an explicit role in supporting memory for unexpected information.
Battle Hymn of the God-Slayers
Authors: Yee Thomas B. 
Published: March 2020

“God is dead,” declared philosopher Friedrich Nietzsche, “… and we have killed him” (1887)—a proclamation that numerous video game protagonists could aptly say by journey's end. The prominent god-slayer trope in video game storylines casts the gameworld's god(s) as the final boss, to be slain by players, inviting connection to real-world religious ideas. Adequate scholarly attention has not been given to the musical features of the god-slayer trope—specifically, the bosses’ unique battle tracks—to discover what the music's meaning contributes to the trope. Quantitative analysis of video games featuring the god-slayer trope reveals that the bosses’ battle tracks may strategically combine rock and sacred music topics for significant semiotic effect.
This article explores the meanings associated with rock and sacred music topics, using analytic methods from the burgeoning field of musical semiotics. By invoking music-theoretic work in topic theory (Monelle 2006, Hatten 2004), agential modalities (Tarasti 1994), and virtual agency (Hatten 2018), I argue that the rock and the sacred music topics initially appear to conflict—but the trope serves as a hermeneutic premise for a meaningful and productive synthesis uniquely fit for the narrative god-slayer trope. Xenoblade Chronicles (2010) forms a striking case study, with its tracks “Zanza” and “The God-Slaying Sword” exemplifying the sacred-rock trope and its semiotic meaning in relation to the game's plot—a narratively apt battle hymn for the game's god-slaying protagonists. Using a cultural-historical lens, the conclusion explores connections between the narrative god-slayer trope and the descent of Japan's god-emperor from divinity to humanity.
Prognostic role of lymphocyte-to-monocyte ratio in pancreatic neuroendocrine neoplasms
Authors: Zhou Wentao , Kuang Tiantao , Han Xu , Chen Wenqi , Xu Xuefeng , Lou Wenhui , Wang Dansong 
Published: March 2020

Objectives
Systemic inflammation markers have been demonstrated to be associated with prognosis in various tumors. In this study, we aimed to assess the value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index and the counts of lymphocyte, monocyte and neutrophil in predicting prognosis among patients with resected pancreatic neuroendocrine neoplasms (pNENs).

Methods
A total of 174 patients were included in the study. Univariate and multivariate analyses were performed to evaluate the predictive roles of inflammation markers for relapse-free survival (RFS) and overall survival (OS) in pNEN patients.

Results
The optimal cut-off values of NLR, LMR and lymphocyte count were 1.9, 5.0 and 1.4 × 109/L, respectively, determined by the X-tile software. RFS was found to be significantly longer in patients with NLR ≤1.9 (P = 0.041), LMR >5.0 (P < 0.001) and lymphocyte count >1.4 × 109/L (P = 0.002) in comparison to those with NLR >1.9, LMR ≤5.0 and lymphocyte count ≤1.4 × 109/L, respectively. Multivariate analysis revealed that LMR (hazard ratio 0.30, 95% CI 0.11–0.85, P = 0.023) was an independent predictor for RFS, but not NLR or lymphocyte count. For long-term survival analysis, patients with NLR ≤1.9 (P = 0.016) were found to be associated with favorable OS, but NLR was not an independent factor validated by multivariate analysis.

Conclusions
Preoperative LMR is an independent systemic inflammation marker to predict relapses in pNEN patients who underwent curative resections, whose clinical value needs to be verified in further large sample-based prospective studies.