bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are poor people poorly heard?
Authors: SEVENANS JULIE , MARIÉ AWENIG , BREUNIG CHRISTIAN , WALGRAVE STEFAAN , SOONTJENS KAROLIN , VLIEGENTHART RENS 
Published: December 2024

AbstractA growing body of literature shows that the preferences of poorer groups in society are less well represented than the preferences of the rich. This paper scrutinises one possible explanation of inequality in representation: that politicians hold biased perceptions of what citizens want. We conducted surveys with citizens and politicians in four countries: Belgium, Switzerland, Canada and Germany. Citizens provided their preferences regarding concrete policy proposals, and then politicians estimated these preferences. Comparing politicians’ estimates with the actual preferences of different social groups, the paper shows that politicians’ perceptions are closer to the preferences of the richer than to those of poorer people for issues that matter most for economic inequality: socio‐economic issues. Further, we find that especially right‐wing politicians tend to think about the preferences of richer societal groups when estimating the preferences of their partisan electorates on socio‐economic matters.
Reconstructing seasonal unimpaired runoff volumes to the San Francisco Estuary: Extending the available record back to water year 1872
Authors: Lai Yuchuan , Hutton Paul H. , Roy Sujoy B. 
Published: December 2024

AbstractUnimpaired flow, also known as “virgin” or “naturalized” flow, is the theoretical runoff that would occur absent human alteration and is a common metric used worldwide to support watershed management, regulation and ecosystem restoration. California water managers use an existing record of unimpaired runoff from 10 watersheds upstream of the San Francisco Estuary to inform a variety of planning and regulatory functions. In this work, we extended the available record by several decades to 1872. This runoff reconstruction, accomplished through a multivariate regression‐based modeling approach, used a novel time series methodology that decomposes and combines sparse records measured at varying locations to generate composite temperature and precipitation input for each watershed. Runoff predictions were used to calculate watershed runoff indices and assign water year classifications using current regulatory conventions. The first third of the extended record (1872–1921) has a significantly higher percentage of wet years and a significantly lower percentage of dry and critically dry years compared with the latter two‐thirds of the record (1922–2021). Consistent with earlier paleohydrology research, this finding indicates the occurrence of a dramatic decadal‐scale hydrologic shift from very wet to very dry conditions during the late 19th and early 20th centuries.
Connectivity of the neuronal network for contextual fear memory is disrupted in a mouse model of third‐trimester binge‐like ethanol exposure
Authors: Morningstar Mitchell D. , Lopez Katalina M. , Mayfield Stefanie S. , Almeida‐Mancero Roberto N. , Marquez Joshua , Flores Andres M. , Hafer Brooke R. , Estrada Edilberto , Holtzman Gwen A. , Goranson Emerald V. , Reid Natalie M. , Aldrich Abigale R. , Ghatalia Desna V. , Patel Juhee R. , Padilla Christopher M. , Chavez Glenna J. , Kelly‐Roman Javier , Bhakta Pooja A. , Valenzuela C. Fernando , Linsenbardt David N. 
Published: December 2024

AbstractBackgroundIn rodents, third‐trimester‐equivalent alcohol exposure (TTAE) produces significant deficits in hippocampal‐dependent memory processes such as contextual fear conditioning (CFC). The present study sought to characterize changes in both behavior and Fos+ neurons following CFC in ethanol (EtOH)‐treated versus saline‐treated mice using TRAP2:Ai14 mice that permanently label Fos+ neurons following a tamoxifen injection. We hypothesized that TTAE would produce long‐lasting disruptions to the networks engaged following CFC with a particular emphasis on the limbic memory system.MethodsOn postnatal day 7, mice received either two injections of saline or 2.5 g/kg EtOH spaced 2 h apart. The mice were left undisturbed until they reached adulthood, at which point they underwent CFC. After context exposure on day 2, mice received a tamoxifen injection. Brain tissue was harvested. Slides were automatically imaged using a Zeiss AxioScanner. Manual counts on a priori regions of interest were conducted. Automated counts were performed on the whole brain using the QUINT 2D stitching pipeline. Last, novel network analyses were applied to identify future regions of interest.ResultsTTAE reduced context recall on day 2 of CFC. Fos+ neural density increased in the CA1 and CA3. Fos+ counts were reduced in the anteroventral (AV) and anterodorsal thalamus. The limbic memory system showed significant hyperconnectivity in male TTAE mice, and the AV shifted affinity toward hippocampal subregions. Last, novel regions such as a subparafascicular area and basomedial amygdalar nucleus were implicated as important mediators.DiscussionThese results suggest that CFC is mediated by the limbic memory system and is disrupted following TTAE. Given the increase in CA1 and CA3 activity, a potential hypothesis is that TTAE causes disruptions to memory encoding following day 1 conditioning. Future studies will aim to determine whether this disruption specifically affects the encoding or retrieval of fear memories.
Decision usefulness of SME financial statements in Sri Lanka
Authors: Wijekoon Nisansala , Sharma Umesh , Samkin Grant 
Published: December 2024

AbstractThis paper examines the users of Sri Lankan small and medium‐sized entities' (SMEs) financial statements, and their information needs. Semi‐structured interviews found the main recipients of SME financial information are banks, the Inland Revenue Department and other government institutions. However, the users' concerns, such as manipulation of financial results, tax orientation, insufficient detail, and out‐of‐date information, hinder the decision usefulness of SME financial statements. Given this context, the widespread problems of unreliability and non‐compliance with accounting principles and standards present a substantial hurdle in evaluating the decision usefulness of SMEs' financial statements in Sri Lanka. The Chartered Accountants of Sri Lanka, regulatory bodies and government authorities need to pay greater attention to SMEs' financial reporting and take steps to make it credible and relevant to users' needs.
Coypu (Myocastor coypus bonaeriensis) Ovarian Morphology During the Oestrous Cycle
Authors: Felipe Antonio Eduardo , Herrera Juan Manuel , Killian Marcelo Pablo , Lombardo Daniel Marcelo 
Published: December 2024

ABSTRACTThe coypu (Myocastor coypus bonariensis) is an annual polyestrous hystricomorph rodent with variable‐length oestrous cycles, which ovarian histoarchitecture during this period is not fully described. This study analyses variations in ovarian morphology during the oestrous cycle, focusing on follicular development and atresia. Eighteen sexually mature virgin females aged 7–9 months, weighing 4.795 ± 0.3996 kg, were used. Daily colpocytological analyses were performed to establish the cycle duration, followed by euthanasia at different phases—prooestrus, estrus, meteostrus, and on days 5, 10, and 20 of dioestrus. Morphology and superficial appearance of the ovaries, weight, and volume at each stage were recorded, and volume increase over time was analysed. A morphological classification and size ranges every 100 μm for follicular development analysis were used. Relative area analysis determined the proportions of different ovarian components and the absolute and relative frequencies of atretic and/or luteinized structures. Our study revealed differences between prooestrus, meteostrus, and all dioestrus phases, as well as between oestrus and metoestrus, and dioestrus at 10 and 20 days. Ovarian surface exhibited variations across different oestrous cycle stages, and atretic follicles were observed in all analysed stages. These findings provide new data and contribute to the understanding of the reproductive cycle in this species.
Efficacy and Safety of Dupilumab in Children With Peanut Allergy: A Multicenter, Open‐Label, Phase II Study
Authors: Sindher Sayantani B. , Nadeau Kari C. , Chinthrajah R. Sharon , Leflein Jeffrey G. , Bégin Philippe , Ohayon Jason A. , Ponda Punita , Wambre Erik , Liu Jinzhong , Khokhar Faisal A. , Akinlade Bolanle , Maloney Jennifer , Orengo Jamie M. , Hamilton Jennifer D. , Kamal Mohamed A. , Hooper Andrea T. , Patel Naimish , Patel Kiran , Laws Elizabeth , Mannent Leda P. , Radin Allen R. 
Published: December 2024

ABSTRACTBackgroundPeanut allergy is a potentially life‐threatening food allergy in children. This study explored whether dupilumab, a human monoclonal immunoglobulin (Ig)G4 antibody that blocks the activity of interleukin (IL)‐4/IL‐13, improved safety and desensitization to peanut exposure in children with peanut allergy.MethodsA Phase II, 24‐week, multicenter, single‐arm, open‐label, proof‐of‐concept study was conducted in the USA and Canada (NCT03793608). Children/adolescents with peanut allergy received subcutaneous dupilumab 300 mg (≥ 60 kg) or 200 mg (≥ 20 to < 60 kg) every 2 weeks. The primary endpoint was the proportion of participants who passed a double‐blind placebo‐controlled food challenge (DBPCFC) with ≥ 444 mg (cumulative) of peanut protein at week 24. Secondary endpoints included safety measures (Consortium of Food Allergy Research grading system) and change from baseline in peanut‐specific (ps)‐IgG4, total IgE, and ps‐IgE.ResultsTwenty‐four participants enrolled and received dupilumab: 75.0% were male, 79.2% were white, mean (standard deviation) age was 11.7 (3.3) years. Most (95.8%) participants had not received allergen immunotherapy. Two participants (8.3%) achieved the primary endpoint and passed the DBPCFC at week 24. Fifteen participants (62.5%) reported 66 treatment‐emergent adverse events, all being mild or in moderate intensity. At the week 24 DBPCFC, 8 participants (33.3%) had a grade 2 allergic reaction (no grade 3 or above); 10 (41.7%) used adrenaline as a rescue medication. Dupilumab treatment resulted in a median reduction of total and ps‐IgE of −54% and −49%, respectively, and a 0% change in ps‐IgG4.ConclusionsDupilumab monotherapy treatment for 24 weeks did not improve desensitization to peanut exposure after food challenge.
Tralokinumab Treatment in Adult Atopic Dermatitis Patients: 28‐Week Evaluation of Clinical Effectiveness, Safety, Serum Proteins and Total IgE Levels
Authors: Dekkers Coco , Zuithoff Nicolaas , Bakker Daphne , Knol Edward , Wevers Anne , Touwslager Wouter , Christoffers Wianda , Prosje Petra , van Lynden‐van Nes Anneke , van Lümig Paula , Kamsteeg Marijke , Oosting Albert Jan , Schuttelaar Marie L. A. , Haeck Inge , de Graaf Marlies , van Wijk Femke , de Bruin‐Weller Marjolein 
Published: December 2024

ABSTRACTIntroduction and ObjectivesTralokinumab—a biological that specifically targets interleukin‐13—is one of the newer advanced systemic treatments for patients with moderate‐to‐severe atopic dermatitis (AD). Although safety and efficacy have been shown in phase‐III clinical trials, daily practice data are needed. Therefore, the aim of this study was to evaluate 28‐week safety and effectiveness, serum proteins and total IgE levels in adult AD patients treated with tralokinumab in daily practice.Materials and MethodsData of all adult AD patients who started treatment with tralokinumab and participated in the BioDay registry were collected at baseline, and after 4,16 and 28 weeks of treatment. Clinical efficacy was evaluated by clinical outcome measures, such as the Eczema Area and Severity Index (EASI) as well as patient‐reported outcome measures, such as the numerical rating scale (NRS) for pruritus. Adverse events were evaluated. In a subgroup of patients, 18 proteins as well as total IgE levels were measured in serum.ResultsA total of 84 patients were included, of whom 39 were dupilumab‐naïve (D‐naïve) and 45 were dupilumab non‐naïve (D‐non‐naïve) patients. All primary outcomes significantly improved during 28 weeks of tralokinumab treatment and the probability of achieving EASI ≤ 7 and NRS‐pruritis ≤ 4 was 75.8% (56.9–88.2) and 51.4% (28.0–74.2), respectively. The disease severity‐associated proteins TARC/CCL17 and PARC/CCL18 decreased during treatment, and total IgE levels significantly decreased in the D‐naïve patients. The most reported adverse events were eye disorders (n = 24, 28.6%). A total of 23 patients (27.4%) discontinued treatment due to adverse events and/or ineffectiveness, with hair loss being the most common adverse event leading to treatment discontinuation (n = 6).ConclusionTralokinumab is an effective treatment for moderate‐to‐severe AD in adult patients, in both dupilumab‐naïve patients and patients who previously failed on dupilumab treatment. The clinical effect is supported by the biological data.
T Cells Induce Prolonged Downregulation of Barrier Molecules in a Mouse Model of Allergic Contact Dermatitis
Authors: Vaher Helen , Gadsbøll Anne‐Sofie Ø. , Seibel Alexandra T. , Kongsbak‐Wismann Martin , Lohmann Rebecca K. D. , Mraz Veronika , Funch Anders B. , Jee Mia H. , Ødum Niels , Woetmann Anders , Geisler Carsten , Bonefeld Charlotte M. 
Published: December 2024

ABSTRACTBackgroundDysfunction of the skin barrier is regarded as a key event in the initiation and progression of inflammatory skin diseases. In many cases of allergic contact dermatitis (ACD), epidermal‐resident memory CD8+ T (TRM) cells play a central role in the immune response to contact allergens. However, if and how allergen‐specific CD8+ TRM cells affect the expression of skin barrier molecules is not known.MethodsThe expression level of skin barrier molecules was determined by RT‐qPCR and immunofluorescence in a mouse model of ACD. The role of CD8+ T cells on the expression of skin barrier molecules was investigated by depletion of CD8+ cells. Human primary keratinocytes were used to assess the direct effect of IFN‐γ and contact allergen on their expression of skin barrier molecules.ResultsSensitization with the contact allergen 1‐fluoro‐2,4‐dinitrobenzene (DNFB) resulted in epidermal accumulation of CD8+ TRM cells and prolonged upregulation of Ifng and downregulation of keratin 5 (Krt5) and Krt14 even after complete macroscopic remission of the inflammatory response. Challenge with DNFB lead to an additionally rapid downregulation of Krt5 and Krt14 and the downregulation of several other skin barrier molecules. Depletion of CD8+ cells abolished both the prolonged and rapid downregulation of skin barrier molecules. In keratinocytes, IFN‐γ and contact allergen synergistically down‐regulated the expression of KRT5 and KRT14.ConclusionCD8+ TRM cells contribute to a prolonged reduction in the expression of skin barrier molecules, which might exacerbate allergen permeation and the inflammatory response during succeeding exposures of the skin to allergens and antigens.
Comparison of balloon catheter, oral misoprostol, or combination of both for cervical ripening in late‐term and post‐term nulliparous women: A Finnish randomized controlled multicenter pilot trial
Authors: Kruit Heidi , Place Katariina , Väyrynen Kirsi , Orden Maija‐Riitta , Tekay Aydin , Vääräsmäki Marja , Uotila Jukka , Tihtonen Kati , Rinne Kirsi , Mäkikallio Kaarin , Heinonen Seppo , Rahkonen Leena 
Published: December 2024

AbstractIntroductionNulliparous women beyond term have high rates of induction failure. The aim of this study was to compare delivery outcomes for balloon catheter, misoprostol, and combination of both in nulliparous late‐ and post‐term women with unfavorable cervices. We intended to explore whether the combination strategy has lower cesarean section rate and is as safe as either method alone.Material and MethodsThe randomized multicenter pilot trial was carried out in the five university hospitals and the largest secondary care hospital of Finland March 1, 2018–March 31, 2022. A total of 273 nulliparous women with viable singleton fetus in cephalic presentation, intact amniotic membranes, and an unfavorable cervix at 41 + 0 gestational weeks were included. The study protocol was registered in the ISCTN registry (ISRCTN83219789). The women were randomized into cervical ripening by balloon catheter, oral misoprostol 50 μg every 4 h, or the combination use of both. The primary outcomes of the study were the rates of cesarean section and composite of adverse neonatal outcomes (5‐min Apgar score <7, umbilical artery pH ≤7.05, or NICU admission).ResultsNinety‐seven women (35.5%) were allocated in the balloon catheter arm, 94 (34.4%) in the oral misoprostol arm, and 82 (30.0%) in the combination treatment arm. The rates of cesarean section (balloon catheter 23.7%, n = 23/97, vs. oral misoprostol 24.5%, n = 23/94, vs. combination 17.1%, n = 14/82) or composite adverse neonatal outcome (7.2% vs. 7.4% vs. 7.3%, respectively) were not statistically significantly different between the groups. The median (interquartile range) induction to delivery interval was the shortest in the combination treatment, 21.7 (15.1–33.2) h compared to balloon catheter 31.7 (21.9–44.5) h; p < 0.01 or oral misoprostol 37.0 (26.7–60.3) h; p < 0.01. The proportion of women with induction to delivery interval ≤24 h was significantly higher in the combination arm compared to balloon catheter (54.4% vs. 31.1%; p < 0.01) or oral misoprostol (54.4% vs. 21.1%; p < 0.001).ConclusionsOur findings confirm the effectiveness of combining balloon catheter and oral misoprostol for cervical ripening, showing shorter induction to delivery interval and comparable rates of cesarean section and neonatal outcomes compared to either method alone. These results advocate for a shift toward adopting combination strategy in the induction of nulliparous late‐ and post‐term women.
The causal relation between career calling and task performance: A three‐wave panel study
Authors: Gerdel Sophie , Dalla Rosa Anna , Duffy Ryan Daniel , Vianello Michelangelo 
Published: December 2024

AbstractWork as a calling theory predicts that perceiving and living out a calling lead to higher task performance, and empirical evidence supports the assumption that perceiving a calling is related to task performance. Yet, the longitudinal precedence between career calling and task performance has not been investigated. This study examines the temporal relationship between career calling and self‐rated task performance using a three‐wave longitudinal design with 285 US employees. Findings from a cross‐lagged panel model analysis indicate that self‐rated task performance predicts career calling more strongly than the reverse. These results suggest that self‐rated task performance outcomes may drive the development of a career calling, challenging traditional assumptions. The study's implications highlight the importance of performance feedback in cultivating employees' sense of purpose and calling. Future research should explore the boundary conditions of this relationship and consider various performance metrics.
Self‐concept clarity and envy as mediators between upward social comparison on social networking sites and subjective well‐being
Authors: Niu Xiang , Gou Li‐Xing , Han Ying , Zhou Xuan , Wang Jin‐Liang 
Published: December 2024

AbstractThe popularity of social networking sites increases opportunities for upward social comparison, potentially affecting individuals' subjective well‐being. However, research on how this comparison impacts well‐being's sub‐components (i.e., positive affect, negative affect, and life satisfaction) is scarce. This study, based on social comparison theory and the full theoretical construct of subjective well‐being, explores these relationships and their mechanisms. A total of 970 Chinese youth participants (Mage = 19.42 years, SD = 2.01) completed self‐report measures. The results showed that the independent mediating effect of envy and the chain mediating effect of self‐concept clarity and envy contributed to all three models. In addition, the independent mediating effect of self‐concept clarity only contributed to the model for negative affect. This study emphasizes that the construct of envy mediates the effect of upward social comparison on the sub‐components of subjective well‐being and further demonstrates a strong impact of upward social comparison on negative affect.
The unrecognized potential of potential‐based achievement goals
Authors: Tempelaar Dirk 
Published: December 2024

AbstractBackgroundFor over a decade, growth‐oriented achievement goal constructs like potential‐based goals and personal best goals have remained relatively unnoticed. This empirical study aims to highlight that goal theorists might be limiting themselves by not incorporating potential‐based goals into their frameworks.AimsThe primary objective of this research was to underscore the significant yet underappreciated role of potential‐based goals in empirical studies within the 3 × 2 achievement goal framework.SamplesThe sample comprises 10,079 international undergraduate students from a Dutch university, drawn from nine cohorts spanning academic years from 2015/2016 to 2023/2024.MethodsTo validate the eight‐factor measurement model of achievement goals, we employed first and second‐order confirmatory factor analyses. Correlational analysis and structural equation models were utilized to explore the relationships between achievement goal measures, various learning dispositions, and academic performance.ResultsOur analysis shows that all eight goal constructs clearly distinguish and confirm both first‐order and second‐order factor analysis models based on approach and avoidance factors. Further analyses include obtaining correlations and structural equation prediction models, where goal setting facets predict learning mindsets, such as intelligence theories, effort beliefs, autonomous and controlled regulation, motivation, engagement, learning approaches, and performance strategies.ConclusionsWithin a system of criterion‐referenced grading of courses, our findings indicate that potential‐based goals play a pivotal role in exploring relationships with other learning dispositions and predicting performance. It is therefore imperative to incorporate these goals into our measurement instruments for goal frameworks, even if it means prioritizing them over other types of intrapersonal goals.