bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring harm in psychotherapy: Perspectives of clinicians working with children and young people
Authors: Castro Batic Barbara , Hayes Dan 
Published: September 2020

AbstractAimsThe potential for harm to occur from talking therapies has been acknowledged in academic literature. However, there is a paucity of research when it comes to exploring this phenomenon when working with young patients. This study explores clinicians’ perspectives on harm from talking therapies when working with children and young people.MethodEleven clinicians were interviewed on the types of harm that could occur from talking therapies, as well as the potential mechanisms. Data were analysed inductively using thematic analysis.ResultsTwo themes were identified around types of harm: ‘clinical deterioration’ and ‘retraumatisation’. Additionally, four groups of mechanisms were identified: ‘Administrative factors’, ‘Relationship factors’, ‘Therapist factors’ and ‘Contextual factors’.DiscussionClinicians are able to identify some specific types of harm when working with children and young people and understand how these could occur. The clinical implications of these findings are explored, along with limitations and directions for future research.
Chemoproteomic Profiling of an Ibrutinib Analogue Reveals its Unexpected Role in DNA Damage Repair
Authors: Ye Zi , Wang Yankun , Wu Hong , Song Tong , Li Xixiang , Liu Qingsong , Wang Chu 
Published: September 2020

AbstractIbrutinib is an FDA‐approved drug to treat B‐lymphoid malignancies, which functions mechanistically as a covalent inhibitor for Bruton's tyrosine kinase (BTK). During the course of screening more potent and selective BTK inhibitors, we discovered that MM2‐48, an ibrutinib analogue that contains the alkynyl amide functional group in place of the acrylamide warhead, exhibits a much stronger cytotoxicity. Comparative chemoproteomic profiling of the targets of ibrutinib and MM2‐48 revealed that the alkynyl amide warhead exhibits much higher reactivity in proteomes. Unexpectedly, MM2‐48 covalently targets a functional cysteine in a BRCA2 and CDKN1A‐interacting protein, BCCIP, and significantly inhibits DNA damage repair. Our findings suggest that simultaneous inhibition of BTK activity and DNA damage repair might be a more effective therapeutic strategy for combating B‐cell malignancies.
A safe and simple method for axIABP placement using a left axillary–radial technique
Authors: Maatman Benjamin , Rios‐Meza Hugo , Guglin Maya , Revtyak George 
Published: September 2020

AbstractIn patients with severe heart failure, a percutaneous axillary intraaortic balloon pump (axIABP) may permit ambulation while awaiting destination therapy. Traditionally, an “axillary–femoral” approach has been used with femoral access for axillary angiography during insertion. We describe an “axillary–radial” technique for axIABP insertion and removal using the left radial artery.
Early experience with the Micro Plug Set for preterm patent ductus arteriosus closure
Authors: Heyden Caitlin M. , El‐Said Howaida G. , Moore John W. , Guyon Peter W. , Katheria Anup C. , Ratnayaka Kanishka 
Published: September 2020

AbstractObjectivesWe intend to describe early experience using a new, commercially available Micro Plug Set for preterm neonate and infant transcatheter patent ductus arteriosus (PDA) occlusion.BackgroundTranscatheter PDA occlusion in premature neonates and small infants is safe and effective. The procedure is early in its evolution.MethodsProcedural and short‐term outcomes of preterm neonates and infants undergoing transcatheter PDA occlusion with a new, commercially available device were reviewed.ResultsEight preterm neonates and infants born at median 27 weeks gestation (23–36 weeks) underwent transcatheter PDA device closure with the Micro Plug Set. The device is short (2.5 mm) with a range of diameters (3, 4, 5, 6 mm) and delivered through a microcatheter. Procedures were performed at median 41 days of age (12–88 days) and at 1690 g (760–3,310 g). Transvenous PDA device occlusion was performed with fluoroscopic and echocardiography guidance. All procedures were successful with complete PDA occlusion. There were no procedural or short‐term adverse events.ConclusionsPreterm neonate and infant transcatheter PDA device closure with a new, commercially available short and microcatheter delivered device (Micro Plug Set) was safe and effective in a small, early series of patients.
Acute infective endocarditis masquerading as septic shock with acute respiratory distress syndrome
Authors: Davis John W. , Virk Fawad , Ahmad Masood 
Published: September 2020

AbstractAny new pulmonary edema warrants an urgent rule out of acute cardiac dysfunction. Because sepsis protocols emphasize rapid stabilization and treatment over etiologic evaluation, some cases of endocarditis may be missed as sepsis with acute respiratory distress syndrome.
Duodenal nodular lymphoid hyperplasia in a patient with IgA deficiency
Authors: Ida Hanae , Maruyama Dai , Maeshima Akiko Miyagi , Kamiya Takahiro , Morio Tomohiro , Izutsu Koji 
Published: September 2020

AbstractMost patients with IgA deficiency are asymptomatic, but duodenal nodular lymphoid hyperplasia is one symptom known to be associated with common variable immunodeficiency (CVID), including selective IgA deficiency and agammaglobulinemia.
Novel treatment setup for urethral carcinoma radiotherapy: A complete response case report
Authors: Molana Seyed Hadi , Rostami Aram , Khajetash Benyamin , Arbabi Kalati Farshid , Tavakol Asieh , Zandi Hasan , Ghaderzadeh Anita , Akbari Mahmoudreza 
Published: September 2020

AbstractA homemade personalized penis holder can provide the reproducibility of the penis during urethra carcinoma (UC) radiotherapy.
One‐Pot Synthesized Nickel‐Doped Hierarchically Porous Beta Zeolite for Enhanced Methanol Electrocatalytic Oxidation Activity
Authors: Wei Xinfa , Li Yan , Hua Zile , Chen Lisong , Shi Jianlin 
Published: September 2020

AbstractHierarchically porous zeolites have been widely explored for catalytic applications owing to their high specific surface area, large pore volume, favorable mass transfer capability and abundant acidic sites. Herein we report the facile synthesis of Ni‐doped hierarchically Beta zeolite (Ni−H‐beta) via one‐pot hydrothermal method, in which Ni is uniformly doped into the zeolite crystalline skeleton in the form of Ni3+ without any nickel oxides being found. The prepared Ni−H‐beta zeolite shows high performance towards the electrocatalytic methanol oxidation reaction (MOR) with a high current density of 1450 A g−1 at 1.65 V vs RHE, which is higher than most non‐precious MOR electrocatalysts. More importantly, the electrochemical MOR performance has been identified to be closely related to the acidic property of the prepared samples. The increase in Al concentration resulted in the formation of strong acid sites, and the consequent MOR activity enhancement. These results provide valuable knowledge and favor the application of transition metals doped hierarchical zeolite for electrocatalytic MOR.
Nickel@Nickel Oxide Dendritic Architectures with Boosted Electrochemical Reactivity for Aqueous Nickel–Zinc Batteries
Authors: Wang Fuxin , Lu Yongzhuang , Zeng Siqi , Song Yin , Zheng Dezhou , Xu Wei , Lu Xihong 
Published: September 2020

AbstractRechargeable alkaline zinc‐ion batteries (ZIBs) have gained extensive attention on account of their inexpensiveness, and high levels of safety and output voltage, but the lack of suitable cathode materials with high energy storage property and long cycle stability limits further development of ZIBs. Herein, we report an effective two‐step electrochemical approach to prepare Ni@NiO core‐shell dendritic architectures as cathode material for rechargeable alkaline ZIBs. Benefiting from the highly active NiO shell and unique core‐shell structure, this Ni@NiO electrode shows an excellent discharge capacity (0.112 mAh cm−2, at 4 mA cm−2) and a high rate capability (63.7 % capacity retention at 40 mA cm−2). Furthermore, the alkaline ZIBs with this Ni@NiO cathode also displays a high energy density of 0.193 mWh cm−2 and a remarkable power density of 65.0 mW cm−2.
Silver(I) Oxide‐/DBU‐Promoted Synthesis of Dihydrofuran Units through Allenyl Silver Formation
Authors: Yu Bao , Perfetto Anna , Allievi Luca , Dhambri Sabrina , Rager Marie‐Noelle , Selkti Mohamed , Ciofini Ilaria , Lannou Marie‐Isabelle , Sorin Geoffroy 
Published: September 2020

AbstractA formal [3+2] cyclization mediated by silver(I) oxide and 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) is described herein. Through a broad variety of carbonyl compounds, this system can promote cyclization reactions with high yield (up to 85 %) and diastereoselectivity (up to 95:5) for a straightforward access to complex and congested dihydrofuran derivatives in one step under mild conditions. Based on DFT studies, the proposed mechanism would involve an allenyl silver intermediate.
Gold‐Catalyzed Oxidative Aminocyclizations of Propargyl Alcohols and Propargyl Amines to Form Two Distinct Azacyclic Products: Carbene Formation versus a 3,3‐Sigmatropic Shift of an Initial Intermediate
Authors: Sasane Amit Vijay , Raj Antony Sekar Kulandai , Chao Tzu‐Hsuan , Chen Mu‐Jeng , Liu Rai‐Shung 
Published: September 2020

AbstractGold‐catalyzed oxidations of propargyl alcohols with nitrones by using a P(tBu)2(o‐biphenyl)Au+ catalyst, afforded bicyclic annulation products from the Mannich reactions of gold enolates. The same reactions of propargyl amines with nitrones by using the same gold catalyst gave distinct oxoarylation products. Our DFT calculations indicate that oxidation of propargyl alcohols with nitrones by using electron‐rich gold catalysts lead only to gold carbenes, which can generate gold enolates or oxoarylation intermediates with enolate species having a barrier smaller than that of oxoarylation species.
Environmental Behaviors and Biological Effects of Engineered Nanomaterials: Important Roles of Interfacial Interactions and Dissolved Organic Matter
Authors: Wang Yanlong , Lei Cheng , Lin Daohui 
Published: September 2020

AbstractWith the fast development of nanotechnology, reactive engineered nanomaterials (ENMs) are increasingly discharged into the environment, where they interact with environmental components and organisms and thus pose potential risks. The interactions‐derived formation of nano‐environmental and nano‐bio interfaces determines environmental behaviors and biological effects of ENMs, and ubiquitous dissolved organic matter (DOM) is bound to impact the interfacial interactions and the resulted environmental risks. Herein, we systematically investigated adsorptive interactions between ENMs and various DOM representatives, and thereby demonstrated the effects of DOM on the aqueous suspension/aggregation, mobility in porous media, adsorption of contaminants, transformation, and biological accumulation and toxicity of ENMs. Overall, we conclude that natural DOM can in general expand environmental distribution of ENMs while limit their toxicity to organisms.What is the most favorite and original chemistry developed in your research group?Nanomaterial pollution chemistry.How do you get into this specific field? Could you please share some experiences with our readers?I started to work on nanomaterial pollution chemistry during my visiting scholar research (2006—2008) in UMass, Amherst, USA. There, I studied chemistry involved in environmental behaviors and biological effects of nanomaterials. Thereafter, this becomes the major research topic in my lab till now.How do you supervise your students?Talk and discuss with them about their research regularly. Being prepared before giving comments or suggestions on their research results to make my viewpoints helpful. Share relevant and latest references with them. Appropriately push them to read, think, and do more. Encourage them to ask more questions about experimental phenomena. Inspire their ambition to publish good papers and become good scientists.What is the most important personality for scientific research?Hungering for truth and novelty.
Et3N‐Catalyzed Cycloaddition Reactions of α‐(Trifluoromethyl)styrenes with 2,2,2‐Trifluorodiazoethane to Access Bis(trifluoromethyl)‐Substituted Pyrazolines
Authors: Li Chunmei , Zhang Xuxue , He Jingjing , Xu Sixue , Cao Song 
Published: September 2020

Main observation and conclusionA novel and practical method for the synthesis of 3,5‐bis(trifluoromethyl)‐4,5‐dihydro‐1H‐pyrazoles by [3+2] cycloaddition reactions of α‐(trifluoromethyl)styrenes with 2,2,2‐trifluorodiazoethane (CF3CHN2) has been developed. The cyclization reaction proceeds smoothly in the presence of a catalytic amount of Et3N, affording a variety of bis(trifluoromethyl)‐substituted 2‐pyrazolines in good to excellent yields. This method also exhibits a broad substrate scope and tolerates various functional groups.
PharmGKB Tutorial for Pharmacogenomics of Drugs Potentially Used in the Context of COVID‐19
Authors: Huddart Rachel , Whirl‐Carrillo Michelle , Altman Russ B. , Klein Teri E. 
Published: September 2020

Pharmacogenomics (PGx) is a key area of precision medicine, which is already being implemented in some health systems and may help guide clinicians toward effective therapies for individual patients. Over the last 2 decades, the Pharmacogenomics Knowledgebase (PharmGKB) has built a unique repository of PGx knowledge, including annotations of clinical guideline and regulator‐approved drug labels in addition to evidence‐based drug pathways and annotations of the scientific literature. All of this knowledge is freely accessible on the PharmGKB website. In the first of a series of PharmGKB tutorials, we introduce the PharmGKB coronavirus disease 2019 (COVID‐19) portal and, using examples of drugs found in the portal, demonstrate some of the main features of PharmGKB. This paper is intended as a resource to help users become quickly acquainted with the wealth of information stored in PharmGKB.
A Multifunctional Triphenylamine–Benzothiazole Derivative with Blue‐Shifted Mechanochromism, Acidochromism and Amplified Spontaneous Emission
Authors: Fang Bing , Lai Liming , Chu Manman , Shi Yan , Yin Meizhen 
Published: September 2020

AbstractA multifunctional triphenylamine (TPA) derivative P1 is synthesized, which contains a TPA skeleton and a benzothiazole group. P1 crystals show blue–green fluorescence and exhibit obviously blue‐shifted mechanochromism upon grinding. Analysis of crystal structures indicate that two adjacent antiparallel P1 molecules form strong intermolecular interactions and adopt a dimeric packing structure, which could be interrupted by mechanical stress, leading to blue‐shifted mechanochromism. Moreover, the proton‐donating acid effectively binds onto the benzothiazole moiety, which greatly enhances the electron‐accepting capacity of the benzothiazole moiety, leading to acidochromism with red‐shifted emission. Additionally, self‐assembled P1 microcrystals exhibit good optical waveguide features and this feature indicates P1 microcrystals serve simultaneously as gain materials and optical resonators for laser oscillation.
Does TMT composition matter to environmental policy and firm performance? The role of organizational slack
Authors: Lee Tingko , Liu Wei‐Tsung , Yu Jun‐Xian 
Published: September 2020

AbstractThis study examines the relationship between the heterogeneity of top management team (TMT) composition and firm performance by focusing on the mediating role of environmental policy: a greenhouse gas (GHG) emission strategy. Organizational slack is viewed as a moderating variable that influences the above mediated relationship. Based on data from Taiwanese public firms with CSR reports, it is found that TMT educational background heterogeneity and tenure heterogeneity negatively influence firm performance, and the GHG emission strategy mediates this relationship. Moreover, this study finds that unabsorbed slack significantly strengthens the influence of TMT educational background heterogeneity on the GHG emission strategy, and unabsorbed slack also moderates the mediation effect of the GHG emission strategy on the relationship between TMT educational background heterogeneity and firm performance. The theoretical and managerial implications of the results are discussed in the discussion section and conclusions of the study.
CD163 deficiency facilitates lipopolysaccharide‐induced inflammatory responses and endotoxin shock in mice
Authors: Fujiwara Yukio , Ohnishi Koji , Horlad Hasita , Saito Yoichi , Shiraishi Daisuke , Takeya Hiroto , Yoshii Daiki , Kaieda Shinjiro , Hoshino Tomoaki , Komohara Yoshihiro 
Published: September 2020

AbstractObjectivesSeptic (or endotoxin) shock is a severe systemic inflammatory disease caused by bacteraemia or endotoxaemia. Although it is known that increased serum levels of CD163 are observed in septic/endotoxin shock patients, the exact function and significance of CD163 in macrophage activation remain unclear. Therefore, in the current study, we tested whether CD163 contributes to the pathogenesis of endotoxin shock in mice.Methods and resultsIn samples obtained from autopsy, the number of CD163‐positive macrophages was increased in the kidney, liver, heart, bone marrow and spleen of patients who had died from septic/endotoxin shock when compared to patients who had died from other causes. The animal study revealed a significantly lower survival rate in CD163‐deficient mice after lipopolysaccharide (LPS) injection. Several cytokines and oxidative stress‐related molecules were significantly elevated in the sera of LPS‐induced endotoxin shock mice models. Higher concentrations of IL‐6, TNF‐α, IL‐1β, nitrite () and nitrate () and a lower concentration of IL‐10 were observed in CD163‐deficient mice treated with LPS. Similar results were observed in CD163‐deficient LPS‐stimulated macrophages. Furthermore, in an antitype II collagen antibody‐induced arthritis (CAIA), rheumatoid arthritis model, inflammation and bone erosion scores as well as the expression of IL‐6 and IL‐1β were significantly increased in CD163‐deficient mice.ConclusionsCD163 was suggested to be involved in the regulation of inflammatory cytokine expression in septic/endotoxin shock and CAIA.
Person‐centered profiles of parasympathetic physiology, anxiety symptoms, and depressive symptoms in mothers and fathers of young children
Authors: Skoranski Amanda M. , Lunkenheimer Erika 
Published: September 2020

AbstractRespiratory sinus arrhythmia (RSA) is a biomarker of mental health, but RSA‐symptom relations in parents of young children are understudied. We examined how anxiety symptoms, depressive symptoms, resting RSA, and RSA reactivity during challenging parent–child interactions clustered in a community sample of mothers (N = 126) and fathers (N = 87) of 3‐year‐olds and whether profiles predicted child emotional and behavioral dysregulation at age 4. Mothers fit four profiles (Typical, Mild Risk, Moderate Risk/Withdrawal, and Moderate Risk/Augmentation), suggesting that RSA reactivity was distinct by predominant symptom type at higher levels of risk: specifically, heightened RSA withdrawal was associated with a higher probability of anxiety symptoms and RSA augmentation was associated with a higher probability of depressive symptoms. Fathers fit three profiles (Typical, Mild Risk, and Moderate Risk) where Moderate Risk was characterized by RSA augmentation and a higher probability of both anxiety and depressive symptoms. Mild risk profiles showed heightened resting RSA for mothers and fathers but no differences in RSA reactivity. Both mild and moderate risk profiles predicted higher child dysregulation 1 year later compared to typical profiles. Findings offer preliminary evidence that parasympathetic physiology covaries with symptoms differently for mothers and fathers and that parental profiles of physiology and symptoms inform children's developmental psychopathology.
A brain and a head for a different habitat: Size variation in four morphs of Arctic charr (Salvelinus alpinus(L.)) in a deep oligotrophic lake
Authors: Peris Tamayo Ana‐Maria , Devineau Olivier , Præbel Kim , Kahilainen Kimmo K. , Østbye Kjartan 
Published: September 2020

AbstractAdaptive radiation is the diversification of species to different ecological niches and has repeatedly occurred in different salmonid fish of postglacial lakes. In Lake Tinnsjøen, one of the largest and deepest lakes in Norway, the salmonid fish, Arctic charr (Salvelinus alpinus(L.)), has likely radiated within 9,700 years after deglaciation into ecologically and genetically segregated Piscivore, Planktivore, Dwarf, and Abyssal morphs in the pelagial, littoral, shallow‐moderate profundal, and deep‐profundal habitats. We compared trait variation in the size of the head, the eye and olfactory organs, as well as the volumes of five brain regions of these four Arctic charr morphs. We hypothesised that specific habitat characteristics have promoted divergent body, head, and brain sizes related to utilized depth differing in environmental constraints (e.g., light, oxygen, pressure, temperature, and food quality). The most important ecomorphological variables differentiating morphs were eye area, habitat, and number of lamellae. The Abyssal morph living in the deepest areas of the lake had the smallest brain region volumes, head, and eye size. Comparing the olfactory bulb with the optic tectum in size, it was larger in the Abyssal morph than in the Piscivore morph. The Piscivore and Planktivore morphs that use more illuminated habitats have the largest optic tectum volume, followed by the Dwarf. The observed differences in body size and sensory capacities in terms of vision and olfaction in shallow and deepwater morphs likely relates to foraging and mating habitats in Lake Tinnsjøen. Further seasonal and experimental studies of brain volume in polymorphic species are needed to test the role of plasticity and adaptive evolution behind the observed differences.
Co‐occurrence history increases ecosystem stability and resilience in experimental plant communities
Authors: van Moorsel Sofia J. , Hahl Terhi , Petchey Owen L. , Ebeling Anne , Eisenhauer Nico , Schmid Bernhard , Wagg Cameron 
Published: September 2020

AbstractUnderstanding factors that maintain ecosystem stability is critical in the face of environmental change. Experiments simulating species loss from grassland have shown that losing biodiversity decreases ecosystem stability. However, as the originally sown experimental communities with reduced biodiversity develop, plant evolutionary processes or the assembly of interacting soil organisms may allow ecosystems to increase stability over time. We explored such effects in a long‐term grassland biodiversity experiment with plant communities with either a history of co‐occurrence (selected communities) or no such history (naïve communities) over a 4‐yr period in which a major flood disturbance occurred. Comparing communities of identical species composition, we found that selected communities had temporally more stable biomass than naïve communities, especially at low species richness. Furthermore, selected communities showed greater biomass recovery after flooding, resulting in more stable post‐flood productivity. In contrast to a previous study, the positive diversity–stability relationship was maintained after the flooding. Our results were consistent across three soil treatments simulating the presence or absence of co‐selected microbial communities. We suggest that prolonged exposure of plant populations to a particular community context and abiotic site conditions can increase ecosystem temporal stability and resilience due to short‐term evolution. A history of co‐occurrence can in part compensate for species loss, as can high plant diversity in part compensate for the missing opportunity of such adaptive adjustments.