bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of coexisting patellofemoral joint osteoarthritis and tibiofemoral joint osteoarthritis in an Indonesian population: A cross-sectional study at a tertiary teaching hospital
Authors: Pontoh Ludwig AP. , Putra Anggaditya , Dilogo Ismail Hadisoebroto , Efar Toto Suryo 
Published: November 2019

ABSTRACT

Introduction:
Historically, the diagnosis and treatment of osteoarthritis has been focused on the tibiofemoral joint solely. For the last two decades, the role of patellofemoral joint and its involvement on the degenerative joint disease has been investigated. To date, no data existed regarding patellofemoral osteoarthritis in our country, Indonesia.

Methods:
We performed a cross sectional study comprising of patients diagnosed with knee osteoarthritis in Fatmawati General Hospital, a tertiary teaching hospital in Jakarta, Indonesia. The subjects underwent knee radiograph from anteroposterior, lateral and skyline views.

Results:
A total of 66 subjects were included, 80% of the subjects were diagnosed with combined patellofemoral and tibiofibular joint osteoarthritis Kellgren-Lawrence grade III-IV. The Western Ontario and McMaster Universities Osteoarthritis Index score was measured 69.3 points, as this might be correlated with the advancement of the disease.

Conclusions:
Combined patellofemoral and tibiofemoral osteoarthritis constitutes a large portion of patients with knee osteoarthitis.

Highlights:
Commutativity, Normativity, and Holism: Lange Revisited
Authors: Cassell Lisa 
Published: November 2019

AbstractLange (2000) famously argues that although Jeffrey Conditionalization is non-commutative over evidence, it’s not defective in virtue of this feature. Since reversing the order of the evidence in a sequence of updates that don’t commute does not reverse the order of the experiences that underwrite these revisions, the conditions required to generate commutativity failure at the level of experience will fail to hold in cases where we get commutativity failure at the level of evidence. If our interest in commutativity is, fundamentally, an interest in the order-invariance of information, an updating sequence that does not violate such a principle at the more fundamental level of experiential information should not be deemed defective. This paper claims that Lange’s argument fails as a general defense of the Jeffrey framework. Lange’s argument entails that the inputs to the Jeffrey framework differ from those of classical Bayesian Conditionalization in a way that makes them defective. Therefore, either the Jeffrey framework is defective in virtue of not commuting its inputs, or else it is defective in virtue of commuting the wrong kinds of ones.
An electronic health record-based strategy to recruit for a Patient Advisory Council for Research: Implications for inclusion
Authors: Bougrab Nassira , Li Dadong , Trachtman Howard , Sherman Scott , Thornton Rachel , Langford Aisha T. 
Published: November 2019

AbstractIn 2017, the NYU Clinical and Translational Science Institute’s Recruitment and Retention Unit created a Patient Advisory Council for Research (PACR) to provide feedback on clinical trials and health research studies. We collaborated with our clinical research informatics team to generate a random sample of patients, based on the International Classification of Diseases, Tenth Revision codes and demographic factors, for invitation via the patient portal. This approach yielded in a group that was diverse with regard to age, race/ethnicity, sex, and health conditions. This report highlights the benefits and limitations of using an electronic health record-based strategy to identify and recruit members for a PACR.
Isotopic variations of meltwater from ice by isotopic exchange between liquid water and ice
Authors: Ham Ji-Young , Hur Soon Do , Lee Won Sang , Han Yeongcheol , Jung Hyejung , Lee Jeonghoon 
Published: November 2019

AbstractPredicting the isotopic modification of ice by melting processes is important for improving the accuracy in paleoclimate reconstruction. To this end, we present results from cold room laboratory observations of changes in the isotopic ratio (D/H and 18O/16O) of ice cubes by isotopic exchange between liquid water and ice in nearly isothermal conditions. A 1-D model was fit to the isotopic results by adjusting the values of two parameters, the isotopic exchange rate constant (kr) and the fraction of ice participating in the exchange (f). We found that the rate constant for hydrogen isotopic exchange between liquid water and ice may be greater (up to 40%) than that for the oxygen isotopic exchange. The range of the rate constant obtained from four melt experiments is from 0.21 to 0.82 h–1. The model results also suggest that f decreases with the increasing wetness of the ice. This is because with increasing water saturation in ice, water may be present only in the small pores or some of the water that was exchanged with ice may be bypassed, decreasing the effective surface area over which the isotopic exchange can occur. The relationship between the two water isotopes (δ18O vs δD) was observed and modeled and the slope was <8, which is significantly different from the slope of the meteoric waterline. We note that these slopes were obtained without considering the sublimation process.
RESTRICTED MAD FAMILIES
Authors: GUZMÁN OSVALDO , HRUŠÁK MICHAEL , TÉLLEZ OSVALDO 
Published: November 2019

AbstractLet ${\cal I}$ be an ideal on ω. By cov${}_{}^{\rm{*}}({\cal I})$ we denote the least size of a family ${\cal B} \subseteq {\cal I}$ such that for every infinite $X \in {\cal I}$ there is $B \in {\cal B}$ for which $B\mathop \cap \nolimits X$ is infinite. We say that an AD family ${\cal A} \subseteq {\cal I}$ is a MAD family restricted to${\cal I}$ if for every infinite $X \in {\cal I}$ there is $A \in {\cal A}$ such that $|X\mathop \cap \nolimits A| = \omega$. Let a$\left( {\cal I} \right)$ be the least size of an infinite MAD family restricted to ${\cal I}$. We prove that If $max${a,cov${}_{}^{\rm{*}}({\cal I})\}$ then a$\left( {\cal I} \right) = {\omega _1}$, and consequently, if ${\cal I}$ is tall and $\le {\omega _2}$ then a$\left( {\cal I} \right) = max$ {a,cov${}_{}^{\rm{*}}({\cal I})\}$. We use these results to prove that if c$\le {\omega _2}$ then o$= \overline o$ and that as$= max${a,non$({\cal M})\}$. We also analyze the problem whether it is consistent with the negation of CH that every AD family of size ω1 can be extended to a MAD family of size ω1.
(Re)inventing development: China, infrastructure, sustainability and special economic zones in Nigeria
Authors: Adunbi Omolade 
Published: November 2019

AbstractThis article interrogates the introduction of special economic zones (SEZs) in Nigeria with an emphasis on the establishment of the Lekki free trade zone (FTZ) in May 2006 by the Lagos State government in partnership with a Chinese consortium, and of the Ogun-Guandong FTZ in Igbesa, Ogun State by the Ogun State government. The aim of the Lekki FTZ, Ogun-Guandong FTZ and other SEZs is to transform Lagos and Ogun states into the manufacturing hub of West Africa and sub-Saharan Africa. These economic zones in Nigeria encompass oil and gas, manufacturing, retail, real estate, and other ancillary companies. Based on interviews and participant observations, this article investigates how differing notions of land ownership circulate within communities affected by the FTZs. I ask how it is that indigenous populations, who fear displacement from their living spaces and socio-economic livelihoods, have begun to utilize claims to ancestral land ownership as symbolic expressions of cultural meanings and belonging that run counter to the property regimes associated with the FTZ project. How does the production of such cultural meanings intersect with the claims and counter-claims of indigeneity, communal ownership, and belonging to a space with a rich history that predates the postcolonial state and the inheritors of state power in Lagos? How is it that FTZs, framed as infrastructure projects designed to make life better for the people, end up displacing populations? In drawing out the connections between large-scale development and displacement, this article examines how communities employ both the tangible and intangible past to show how contestations over land ownership are reshaping new forms of community history and culture.
Direct construction of optimized stellarator shapes. Part 3. Omnigenity near the magnetic axis
Authors: Plunk Gabriel G. , Landreman Matt , Helander Per 
Published: November 2019

The condition of omnigenity is investigated, and applied to the near-axis expansion of Garren & Boozer (Phys. Fluids B, vol. 3 (10), 1991a, pp. 2805–2821). Due in part to the particular analyticity requirements of the near-axis expansion, we find that, excluding quasi-symmetric solutions, only one type of omnigenity, namely quasi-isodynamicity, can be satisfied at first order in the distance from the magnetic axis. Our construction provides a parameterization of the space of such solutions, and the cylindrical reformulation and numerical method of Landreman & Sengupta (J. Plasma Phys., vol. 84 (6), 2018, 905840616); Landreman et al. (J. Plasma Phys., vol. 85 (1), 2019, 905850103), enables their efficient numerical construction.
Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients
Authors: Lai Wen-tao , Deng Wen-feng , Xu Shu-xian , Zhao Jie , Xu Dan , Liu Yang-hui , Guo Yuan-yuan , Wang Ming-bang , He Fu-sheng , Ye Shu-wei , Yang Qi-fan , Liu Tie-bang , Zhang Ying-li , Wang Sheng , Li Min-zhi , Yang Ying-jia , Xie Xin-hui , Rong Han 
Published: November 2019

AbstractBackgroundThe microbiota–gut–brain axis, especially the microbial tryptophan (Trp) biosynthesis and metabolism pathway (MiTBamp), may play a critical role in the pathogenesis of major depressive disorder (MDD). However, studies on the MiTBamp in MDD are lacking. The aim of the present study was to analyze the gut microbiota composition and the MiTBamp in MDD patients.MethodsWe performed shotgun metagenomic sequencing of stool samples from 26 MDD patients and 29 healthy controls (HCs). In addition to the microbiota community and the MiTBamp analyses, we also built a classification based on the Random Forests (RF) and Boruta algorithm to identify the gut microbiota as biomarkers for MDD.ResultsTheBacteroidetesabundance was strongly reduced whereas that ofActinobacteriawas significantly increased in the MDD patients compared with the abundance in the HCs. Most noteworthy, the MDD patients had increased levels ofBifidobacterium, which is commonly used as a probiotic. Four Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologies (KOs) (K01817, K11358, K01626, K01667) abundances in the MiTBamp were significantly lower in the MDD group. Furthermore, we found a negative correlation between the K01626 abundance and the HAMD scores in the MDD group. Finally, RF classification at the genus level can achieve an area under the receiver operating characteristic curve of 0.890.ConclusionsThe present findings enabled a better understanding of the changes in gut microbiota and the related Trp pathway in MDD. Alterations of the gut microbiota may have the potential as biomarkers for distinguishing MDD patients form HCs.
On evolutionary religion (in interaction with Rottschaefer, Elliott, Dumsday, and Palmqvist)
Authors: SCHELLENBERG J. L. 
Published: November 2019

AbstractHere I explain the concept of evolutionary religion and consider its relations to what in previous work I have called sceptical religion. I also interact with five articles recently published in Religious Studies that respond to my work and address related themes – articles by William A. Rottschaefer, James Elliott, Travis Dumsday, and Carl-Johan Palmqvist.
Roosevelt's Populism: The Kansas Oil War of 1905 and the Making of Corporate Capitalism
Authors: Williams Kyle 
Published: November 2019

AbstractThe map of the American petroleum industry shifted rapidly from the Northeast to the Southwest at the turn of the twentieth century when spectacular gushers were struck first in Texas and soon in California, Kansas, and Oklahoma. The flood of small and mid-size oil producers broke the hold that the Standard Oil Company had for decades held on the industry. Competition defeated monopoly. Or so the conventional story goes. This article offers a more complicated narrative by focusing on conflicts between Standard Oil and independent producers in the booming towns of southeast Kansas in 1904 and 1905. In those years, John D. Rockefeller's firm established a monopoly through technologies of distribution and distillation and the production of scientific knowledge and opaque classifications of commodities. Oil producers revolted. A reform movement turned to the rhetoric and policy ideas of Populism as it sought to use state power to challenge the stranglehold of the “octopus.” This article explores the previously unrecognized significance of this movement by showing how the Kansas oil war contributed to the breakup of Standard Oil by the Supreme Court in 1911 and constituted one of the bottom-up sources for the reconstruction of American capitalism.
Integration of residual herbicides with cover crop termination in soybean
Authors: Whalen Derek M. , Shergill Lovreet S. , Kinne Lyle P. , Bish Mandy D. , Bradley Kevin W. 
Published: November 2019

AbstractCover crops have increased in popularity in midwestern U.S. corn and soybean systems in recent years. However, little research has been conducted to evaluate how cover crops and residual herbicides are effectively integrated together for weed control in a soybean production system. Field studies were conducted in 2016 and 2017 to evaluate summer annual weed control and to determine the effect of cover crop biomass on residual herbicide reaching the soil. The herbicide treatments consisted of preplant (PP) applications of glyphosate plus 2,4-D with or without sulfentrazone plus chlorimuron at two different timings, 21 and 7 d prior to soybean planting (DPP). Cover crops evaluated included winter vetch, cereal rye, Italian ryegrass, oat, Austrian winter pea, winter wheat, and a winter vetch plus cereal rye mixture. Herbicide treatments were applied to tilled and nontilled soil without cover crop for comparison. The tillage treatment resulted in low weed biomass at all collection intervals after both application timings, which corresponded to tilled soil having the highest sulfentrazone concentration (171 ng g−1) compared with all cover crop treatments. When applied PP, herbicide treatments applied 21 DPP with sulfentrazone had greater weed (93%) and waterhemp (89%) control than when applied 7 DPP (60% and 69%, respectively). When applied POST, herbicide treatments with a residual herbicide resulted in greater weed and waterhemp control at 7 DPP (83% and 77%, respectively) than at 21 DPP (74% and 61%, respectively). Herbicide programs that included a residual herbicide had the highest soybean yields (≥3,403 kg ha−1). Results from this study indicate that residual herbicides can be effectively integrated either PP or POST in conjunction with cover crop termination applications, but termination timing and biomass accumulation will affect the amount of sulfentrazone reaching the soil.
The Role of Crustal Buoyancy in the Generation and Emplacement of Magmatism During Continental Collision
Authors: Schliffke Nicholas , van Hunen Jeroen , Magni Valentina , Allen Mark B. 
Published: November 2019

AbstractDuring continental collision, considerable amounts of buoyant continental crust subduct to depth and subsequently exhume. Whether various exhumation paths contribute to contrasting styles of magmatism across modern collision zones is unclear. Here we present 2D thermomechanical models of continental collision combined with petrological databases to investigate the effect of the main contrasting buoyancy forces, in the form of continental crustal buoyancy versus oceanic slab age (i.e., its thickness). We specifically focus on the consequences for crustal exhumation mechanisms and magmatism. Results indicate that it is mainly crustal density that determines the degree of steepening of the subducting continent and separates the models' parameter space into two regimes. In the first regime, high buoyancy values (∆ρ > 500 kg/m3) steepen the slab most rapidly (to 45–58°), leading to opening of a gap in the subduction channel through which the subducted crust exhumes (“subduction channel crustal exhumation”). A shift to a second regime (“underplating”) occurs when the density contrast is reduced by 50 kg/m3. In this scenario, the slab steepens less (to 37–50°), forcing subducted crust to be placed below the overriding plate. Importantly, the magmatism changes in the two cases: Crustal exhumation through the subduction channel is mainly accompanied by a narrow band of mantle melts, while underplating leads to widespread melting of mixed sources. Finally, we suggest that the amount (or density) of subducted continental crust, and the resulting buoyancy forces, could contribute to contrasting collision styles and magmatism in the Alps and Himalayas/Tibet.
The cytokine network involved in the host immune response to periodontitis
Authors: Pan Weiyi , Wang Qingxuan , Chen Qianming 
Published: November 2019

AbstractPeriodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.
β-Arrestin 1 (ARRB1) serves as a molecular marker of the peripheral circadian rhythm
Authors: Tomita Tatsunosuke , Mori Taisuke , Onishi Yoshiaki 
Published: November 2019

Abstract
The control of the circadian rhythm is important for health because it regulates physiological functions and is associated with health hazards. We aimed to identify a circadian biomarker of health status in human saliva, since collecting saliva is non-invasive, straightforward, and cost-effective. Among 500 genes potentially controlled by the salivary clock identified using chromatin immunoprecipitation (ChIP) assays, 22 of them showed reasonable transcriptional responses according to a DNA array in a salivary model system. Among these 22 genes, ARRB1, which is expressed in human salivary glands, was also expressed in model HSG cells at the transcriptional and translational levels. The profile of ARRB1 expression in human saliva was circadian, suggesting that ARRB1 could serve as a candidate circadian biomarker in saliva. We compared ARRB1 with other biomarkers in salivary samples from jet-lagged individuals. The circadian profile of ARRB1 reflected the time lag more than the profile of melatonin, whereas the profiles of cortisol and α-amylase did not reflect the time lag. Overall, these findings suggest that salivary ARRB1 could serve as a candidate biomarker that could be used to monitor the internal body clock.
Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson’s disease
Authors: Dionísio Pedro A. , Oliveira Sara R. , Gaspar Maria M. , Gama Maria J. , Castro-Caldas Margarida , Amaral Joana D. , Rodrigues Cecilia M. P. 
Published: November 2019

AbstractParkinson’s disease (PD) is driven by dopaminergic neurodegeneration in the substantia nigra pars compacta (SN) and striatum. Although apoptosis is considered the main neurodegenerative mechanism, other cell death pathways may be involved. In this regard, necroptosis is a regulated form of cell death dependent on receptor interacting protein 3 (RIP3), a protein also implicated in apoptosis and inflammation independently of its pro-necroptotic activity. Here, we explored the role of RIP3 genetic deletion in in vivo and in vitro PD models. Firstly, wild-type (Wt) and RIP3 knockout (RIP3ko) mice were injected intraperitoneally with MPTP (40 mg/kg, i.p.), and sacrificed after either 6 or 30 days. RIP3ko protected from dopaminergic neurodegeneration in the SN of MPTP-injected mice, but this effect was independent of necroptosis. In keeping with this, necrostatin-1s (10 mg/kg/day, i.p.) did not afford full neuroprotection. Moreover, MPTP led to DNA fragmentation, caspase-3 activation, lipid peroxidation and BAX expression in Wt mice, in the absence of caspase-8 cleavage, suggesting intrinsic apoptosis. This was mimicked in primary cortical neuronal cultures exposed to the active MPTP metabolite. RIP3 deficiency in cultured cells and in mouse brain abrogated all phenotypes. Curiously, astrogliosis was increased in the striatum of MPTP-injected Wt mice and further exacerbated in RIP3ko mice. This was accompanied by absence of microgliosis and reposition of glial cell line-derived neurotrophic factor (GDNF) levels in the striata of MPTP-injected RIP3ko mice when compared to MPTP-injected Wt mice, which in turn showed a massive GDNF decrease. RIP3ko primary mixed glial cultures also presented decreased expression of inflammation-related genes upon inflammatory stimulation. These findings hint at possible undescribed non-necroptotic roles for RIP3 in inflammation and MPTP-driven cell death, which can contribute to PD progression.
Pitfalls in transboundary Indus Water Treaty: a perspective to prevent unattended threats to the global security
Authors: Qamar Muhammad Uzair , Azmat Muhammad , Claps Pierluigi 
Published: November 2019

AbstractWater treaties have played an important role in peaceful resolution of water-related conflicts. Although the mode of negotiation to resolve water-related conflicts may vary from treaty to treaty, a number of structural falls make them unprepared for the future needs. The Indus water treaty is perhaps quoted as the most successful water-sharing mechanism in the recent times. Against all odds, the treaty has fulfilled its job descriptions of being a mechanism providing a moderately reliable framework for the peaceful resolution of water-related conflicts. However, the climate change is quickly eroding that trust. The water-sharing mechanism lacks guidelines to cater the issues related to climate change and basin sustainability which require integrated approach for their addressal. But the structural inflexibility does not encourage the riparian to collaborate and build mutual trust for common good. The riparian countries, within the framework of treaty, attempt to elevate their national interests by deliberately refusing to comply with the treaty clauses in letter and spirit, and even manipulate data to deprive the competing riparian of water. We propose and argue on the need of adopting structurally sound forum for solving water conflicts which will assist in comprehensive policy-making to ensure the sustainability of transboundary water resources. The forum will also provide an opportunity for the riparian to work together towards confidence-building through sharing of real-time hydrological data and further scientific analysis based on that. Conclusively, the shortcomings of the present conflict-resolution method are addressed by encouraging riparian to collaborate at various levels.