bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cascade network for the classification of rice grain based on single rice kernel
Authors: Robert Singh Ksh , Chaudhury Saurabh 
Published: February 2020

AbstractThis paper describes the classification of four different varieties of rice grain based on four sets of features, namely morphology, colour, texture and wavelet. The classification is carried out on single rice kernel using image pre-processing steps followed by a cascade network classifier. The performance of the classifiers based on the above feature sets is also compared. It is found that morphological feature is more suitable for the classification of rice kernels, as compared to other features. The number of input features is reduced by a feature selection process using statistical analysis system (SAS) software. The classification accuracy based on selected features is compared with that of original features using different classifiers. It is found that the selected features are able to provide classification accuracy very close to the original features. The performance of the proposed cascade classifier is also tested against standard datasets from the University of California, Irvine (UCI), and the results are compared with other classifiers. The results show that the proposed classifier provides better classification accuracy as compared to other classifiers.
Non-contact electrochemical evaluation of biofilms
Authors: Turick Charles E. , Colon-Mercado Hector , Bagwell Christopher E. , Greenway Scott D. , Amoroso Jake W. 
Published: February 2020

Abstract
Here, we demonstrate a non-contact technique for electrochemical evaluation of biofilms on surfaces in relation to corrosion. Electrochemical impedance spectrometry was employed, incorporating flat patterned electrodes positioned over the surfaces of aluminum and glass with and without biofilms. Signal communication from the working electrode to the counter electrode followed electric field lines passing tangentially through the biofilms. Electrochemical impedance parameters that were evaluated included complex impedance, phase angle, imaginary (out of phase) conductivity and Cole–Cole plots with a corresponding equivalent circuit. Changes in the impedance properties due to the presence of biofilms were monitored and correlated through microbiological, chemical and electrochemical assays. Impedance parameters associated with microbial activity correlated with biofilms on aluminum and glass surfaces. This technical approach provides impedance information about the biofilm without the signal traveling through the underlying conductive media or disrupting the biofilm. In this way, biological contributions to surface fouling can be evaluated with minimal contribution from the inorganic surface under the biofilm. In addition, this technique can be used to monitor biofilms on electrochemically inert surfaces as well as electrically conductive surfaces.

Graphic abstract
Relational aggression and victimization during adolescence: A meta‐analytic review of unique associations with popularity, peer acceptance, rejection, and friendship characteristics
Authors: Casper Deborah M. , Card Noel A. , Barlow Caroline 
Published: February 2020

ABSTRACTIntroductionThis meta‐analysis includes 46 studies including 35,468 adolescents (M age = 12.4 years) with a mean sample ages between 10 and 17 years. Just over half of the studies include samples drawn from the U.S. with the remaining samples representing 11 different countries.MethodWe examined the magnitude of overlap between relational aggression and relational victimization and, using infrequently used semipartial correlations as effect sizes, we examined unique associations of each with peer acceptance, peer rejection, popularity, and positive friendship characteristics.Results & conclusionsResults indicate a strong intercorrelation between relational aggression and victimization ( = .48). We found no mean level gender difference in experiences of relational aggression or relational victimization. Relational aggression is positively associated with popularity; victimization is negatively associated with peer acceptance and friendship characteristics. Both, aggression and victimization are positively associated with rejection. We explored method of assessment as a potential source of variability of effect sizes as well as potential publication bias. Future research and implications for prevention and intervention are discussed.
The Effect of Transendocardial Stem Cell Injection on Erectile Function in Men with Cardiomyopathy: Results From the TRIDENT, POSEIDON, and TAC-HFT Trials
Authors: Ory Jesse , Saltzman Russell G. , Blachman-Braun Ruben , Dadoun Simon , DiFede Darcy L. , Premer Courtney , Hurwitz Barry , Hare Joshua M. , Ramasamy Ranjith 
Published: February 2020

Abstract

Background
Despite limited human data, there is a growing interest in the use of stem cell therapy (SCT) for erectile dysfunction (ED).

Aim
To determine the effect of transendocardial stem cell injection on erectile function on men with cardiomyopathy and ED.

Methods
We used International Index of Erectile Function (IIEF) scores collected from men enrolled in 3 separate randomized controlled trials: Comparison of Allogeneic vs Autologous Bone Marrow–Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients With Ischemic Cardiomyopathy (POSEIDON), Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy (TAC-HFT), and Dose Comparison Study of Allogeneic Mesenchymal Stem Cells in Patients With Ischemic Cardiomyopathy (TRIDENT). These trials recruited patients with ischemic cardiomyopathy and ejection fraction less than 50%. Inclusion and exclusion criteria were identical in all 3 trials. The primary intervention in these trials included transendocardial stem cell injection of stem cells or placebo via cardiac catheterization. The follow-up period was 1 year. IIEF data were collected at baseline and at multiple time points in each trial.

Outcomes
We investigated erectile function over time based on cell dose, cell source (autologous vs allogenic), cell type (mesenchymal stem cells vs bone marrow mononuclear cells), and comparing men who received SCT with those who received placebo.

Results
A total of 36 men were identified with complete IIEF data. 8 men received placebo injection, and 28 received SCT. The median age was 66.5 years. Comorbidities were similar among all men. Analysis was performed on men with ED, defined by an IIEF-EF score of 24 or less. In the placebo and all-comer SCT group, the median IIEF-EF score was 5 [1–8] and 5 [1–15] at baseline and was 3.5 [3–5.8] and 7 [1–18] at 12 months (P &gt; .05). When analyzed by cell dose, the IIEF-EF score in men who received 200 million cells increased significantly over 12 months (14 [4–23] to 20 [15–24.5], P = .014.) Similarly, an autologous cell source resulted in a similar increase from baseline to 12 months (14 [3.8–23.3] to 20 [12–22], P = .030).

Clinical Implications
Erectile function may improve after systemic delivery of SCT in men with ischemic cardiomyopathy and at least mild ED.

Strengths & Limitations
This post hoc analysis is the first to investigate the effect of SCT on erectile function using randomized, placebo-controlled data. Weaknesses include that ED was not a primary end point, and men were not originally recruited based on erectile function.

Conclusion
Future trials on systemic delivery of SCT for ED should focus on high cell dose and autologous cell source, as these seem to provide the best response in men with at least mild ED.
The effect of postprandial glycaemia on cognitive function: a randomised crossover trial
Authors: Marchand Olivia M. , Kendall Fiona E. , Rapsey Charlene M. , Haszard Jillian J. , Venn Bernard J. 
Published: February 2020

AbstractThe effect on cognitive test scores of generating differences in postprandial glycaemia using test foods or beverages has been inconsistent. Methodological issues may account for some of the variable results requiring further investigation using strong study designs into the relationship between glycaemia and cognitive functioning. The objective of this study was to determine the effects of postprandial glycaemia on cognitive function by examining cognition after consumption of foods that differ only by the rate of digestion of available carbohydrate in a population of young adults. In a double-blind, randomised, crossover trial, sixty-five participants received trifle sweetened either with a higher-glycaemic index (GI) sugar (sucrose; GI 65) or a lower-GI sugar (isomaltulose; GI 34). Cognitive tests were completed prior to trifle consumption, and 60 and 120 min after. There was no between-trifle difference at 60 min in performance on free word recall (0·0 (95 % CI –0·6, 0·5)), short delay word recall (0·0 (95 % CI –0·5, 0·5)), long delay word recall (0·0 (95 % CI –0·6, 0·6)), letter–number sequence recall (0·3 (95 % CI − 0·2, 0·7)) and visuo-spatial recall (–0·2 (95 % CI –0·6, 0·2)) tests. At 120 min, no difference was detected in any of these tests. The participants performed 7·7 (95 % CI 0·5,14·9) s faster in Reitan’s trail-making test B 60 min after the higher-GI trifle than the lower-GI trifle (P = 0·037). Our findings of a null effect on memory are generally consistent with other works in which blinding and robust control for confounding have been used.
THE AUTHORITY OF FEELING IN MID-TWENTIETH-CENTURY ENGLISH CONSERVATISM
Authors: ROBINSON EMILY 
Published: February 2020

AbstractConservatism claims to be a philosophy of common sense and everyday experience, in which sensation takes priority over reason. This article asks how this was understood by both Conservative thinkers and grassroots members in mid-twentieth-century England, and how it sat alongside other ways of understanding the feelings and experiences of ordinary people, in a period in which these came to be regarded as a privileged form of political authority. The article shows that the Conservative everyday was rooted in individual sensory experiences, but always underpinned by the collective evocation of reverence, majesty, and awe. It traces understandings of the everyday and the awesome through political texts and grassroots publications, showing that the tension between them is what gives Conservatism its distinctive character. This is conceptualized in Burkean terms as the beautiful and the sublime. The latter guarantees order, hierarchy, and allegiance, while the former works to soften and socialize power – making it seem a matter of custom and common sense. The article suggests that this combination enabled Conservatism to adapt to the challenges of mass democracy but became ever harder to sustain in the emotional culture of post-war England, when feelings became a marker of personal authenticity, rather than cultural authority.
Long term dietary supplementation with microalgae increases plasma docosahexaenoic acid in milk and plasma but does not affect plasma 13,14-dihydro-15-keto PGF2α concentration in dairy cows
Authors: Till Bethan E. , Huntington James A. , Kliem Kirsty E. , Taylor-Pickard Jules , Sinclair Liam A. 
Published: February 2020

AbstractThe aims of the study were to determine the long-term effects of dietary supplementation with microalgae (SCIM) on milk and blood fatty acid (FA) composition and reproductive hormones in early lactation dairy cows. Sixty Holstein–Friesian dairy cows (30 per treatment) were unsupplemented (Control) or supplemented with 100 g of SCIM (Schizochytrium limacinum sp.) per cow per day from 25 ± 0.5 d post-partum for 98 d. Intake and milk yield were recorded daily, with milk samples collected at weeks 0, 1, 2, 4, 8 and 14, and blood samples collected from 12 representative pairs per treatment at weeks 0, 2, 4, 8, and 14 for subsequent analysis of FA, β-hydroxybutyrate, non-esterified fatty acids and glucose. At 33 ± 0.9 d postpartum the oestrus cycle of 24 cows (12 per treatment) were synchronized and plasma 13,14-dihydro-15-keto PGF2α (PGFM) concentrations determined following an oxytocin challenge. Data were analysed by repeated measures analysis of variance. There was no effect of treatment on dry matter intake, milk yield or milk fat content, with mean values across treatments of 22.1 and 40.6, and 37.2 g/kg respectively. Milk fat concentration of C22:6 n-3 increased rapidly in cows receiving SCIM, reaching a maximum of 0.38 g/100 g FA by week 14. Similarly, blood concentration of C22:6 n-3 increased to 1.6 g/100 g FA by week 14 in cows fed SCIM. There was no effect of treatment on plasma metabolites, but plasma glucose was lower in cows fed SCIM compared to the Control at week 2, and higher in week 8. There was no effect of treatment on peak plasma PGFM concentration or area under the curve. It is concluded that feeding SCIM rapidly increases blood and milk concentrations of C22:6 n-3 which are maintained over time, but does not improve plasma PGFM in dairy cows.
Crayfish plague affects juvenile survival and adult behaviour of invasive signal crayfish
Authors: Thomas John Rhidian , Robinson Chloe V. , Mrugała Agata , Ellison Amy R. , Matthews Emily , Griffiths Siân W. , Consuegra Sofia , Cable Jo 
Published: February 2020

AbstractThe spread of invasive, non-native species is a key threat to biodiversity. Parasites can play a significant role by influencing their invasive host's survival or behaviour, which can subsequently alter invasion dynamics. The North American signal crayfish (Pacifastacus leniusculus) is a known carrier ofAphanomyces astaci, an oomycete pathogen that is the causative agent of crayfish plague and fatal to European crayfish species, whereas North American species are considered to be largely resistant. There is some evidence, however, that North American species, can also succumb to crayfish plague, though howA. astaciaffects such ‘reservoir hosts’ is rarely considered. Here, we tested the impact ofA. astaciinfection on signal crayfish, by assessing juvenile survival and adult behaviour following exposure toA. astacizoospores. Juvenile signal crayfish suffered high mortality 4-weeks post-hatching, but not as older juveniles. Furthermore, adult signal crayfish with high-infection levels displayed altered behaviours, being less likely to leave the water, explore terrestrial areas and exhibit escape responses. Overall, we reveal thatA. astaciinfection affects signal crayfish to a much greater extent than previously considered, which may not only have direct consequences for invasions, but could substantially affect commercially harvested signal crayfish stocks worldwide.
Delineating the Seasonally Modulated Nonlinear Feedback Onto ENSO From Tropical Instability Waves
Authors: Xue Aoyun , Jin Fei‐Fei , Zhang Wenjun , Boucharel Julien , Zhao Sen , Yuan Xinyi 
Published: February 2020

AbstractTropical instability waves (TIWs), the dominant form of eddy variability in the tropics, have a peak period at about 5 weeks and are strongly modulated by both the seasonal cycle and El Niño–Southern Oscillation (ENSO). In this study, we first demonstrated that TIW‐induced nonlinear dynamical heating (NDH) is basically proportional to the TIW amplitude depicted by a complex index for TIW. We further delineated that this NDH, capturing the seasonally modulated nonlinear feedback of TIW activity onto ENSO, is well approximated by a theoretical formulation derived analytically from a simple linear stochastic model for the TIW index. The results of this study may be useful for the climate community to evaluate and understand the TIW‐ENSO multiscale interaction.
Evaluation of Silicic Acid Sources for Spring Diatom Blooms on the Continental Shelf: Insights FromStable Silicon Isotopes in the East China Sea
Authors: Zhang Anyu , Zhang Jing , Liu Sumei , Xuan Jiliang , Zhu Zhuoyi 
Published: February 2020

AbstractThe concentration of dissolved silicic acid (DSi) and its isotopic composition (δ30Si(OH)4) were determined for the East China Sea (ECS) shelf in the spring season with high spatial resolution. DSi concentrations and δ30Si(OH)4 values ranged from 1.3 to 116.5 μM and +0.85‰ to +2.53‰, respectively. An enrichment of 30Si was observed in most surface‐water samples compared with bottom waters. Several shallow‐water stations at water depths of <20 m reflected the overall control of biological utilization of DSi and regeneration of DSi from biogenic silica (BSi) on the distribution of δ30Si(OH)4 values. A seasonal difference in δ30Si(OH)4 values was observed in the euphotic zone of shelf waters, which is attributed mainly to continuous consumption of DSi in enhanced diatom blooms. The major water masses influencing the ECS shelf were characterized with distinct DSi concentrations and isotopic compositions. Using Si isotopic constraints, modeling of δ30Si(OH)4 values implied that utilization of DSi in the ECS occurred as if in a steady‐state mode. Riverine input was the major DSi source for the surface waters of inner‐shelf areas, as well as part of the middle‐ and outer‐shelf surface waters near the Changjiang River estuary. Upwelled Kuroshio Subsurface Water from the shelf break supported diatom growth in middle‐shelf surface waters. Taiwan Strait Warm Water and Kuroshio Surface Water were relatively oligotrophic, and their influence was confined to waters near the Taiwan Strait and the outer shelf and slope areas.
The Influence of Pre‐existing Basement Faults on the Cenozoic Structure and Evolution of the Proximal Domain, Northern South China Sea Rifted Margin
Authors: Ye Qing , Mei Lianfu , Shi Hesheng , Du Jiayuan , Deng Peng , Shu Yu , Camanni Giovanni 
Published: February 2020

AbstractIn this paper, we investigate the structure of the Cenozoic rift basin in the proximal domain of the northern South China Sea (SCS) margin, with an emphasis on the influence exerted by pre‐existing basement faults on rift development. Results of our work indicate that the overall rift architecture of the proximal domain of the northern SCS margin is associated with extensional faults arranged in two main structural trends, WNW‐ to EW‐trending and ENE‐trending. Structural evidence presented in this paper suggests that extensional faults of the two main structural trends mainly reactivated two pre‐existing basement fault systems mapped in previous works, a WNW‐ to EW‐striking thrust fault system (PFS1) and an ENE‐striking thrust fault system (PFS2). During the first rifting phase, both pre‐existing fault systems were reactivated; however, strains and depocenters were mainly localized on the ENE‐striking normal fault system that reactivated the PFS2. On the contrary, in the second rifting phase, extension was mainly accommodated by WNW‐ to EW‐striking normal faults that reactivated the PFS1, while most of the earlier ENE‐striking normal faults became inactive or less active. These different degrees of reactivation of the two pre‐existing fault systems during the two rifting phases suggest a clockwise rotation of the regional extension direction from NNW‐SSE in the Syn‐rift stage 1 to N‐S in the Syn‐rift stage 2. This study implies that apart from Cenozoic tectonic processes, pre‐existing structures have also played a key role during rifting evolution across the SCS margin.
Too Big to Ignore: Global Risk Perception Gaps Between Scientists and Business Leaders
Authors: Garschagen Matthias , Wood Sylvia L. R. , Garard Jennifer , Ivanova Maria , Luers Amy 
Published: February 2020

AbstractTwo major reports assessing global systemic risks have been published recently, presenting large‐scale panel data on the risk perceptions of different key communities, most notably business leaders and global change scientists. While both of these global communities agree on ranking environmental risks the highest, followed by societal, geopolitical, technological, and economic risks, business leaders perceive the likelihood of most risks as lower than scientists. This gap implies vexing questions in relation to building a shared sense of urgency and facilitating collective action. These questions need to be addressed through new ways of co‐creating risk assessments and strategic futures analysis.
Beractant and poractant alfa in premature neonates with respiratory distress syndrome: a systematic review of real-world evidence studies and randomized controlled trials
Authors: Sánchez Luna Manuel , Bacher Peter , Unnebrink Kristina , Martinez-Tristani Marisol , Ramos Navarro Cristina 
Published: February 2020

AbstractFindings from previous meta-analyses of randomized clinical trials (RCTs) in premature infants with respiratory distress syndrome (RDS) varied as to whether clinical outcomes differed by type of animal-derived pulmonary surfactant; real-world evidence (RWE) was excluded. We extracted study characteristics and outcomes from full-text articles from a systematic search for studies that compared beractant with poractant alfa for RDS in preterm infants. RWE data were tabulated; RCT data were subjected to meta-analyses. Designs, patient characteristics, and follow-up durations varied widely among studies (4 RWE, 15 RCT). RWE studies with adjusted odds ratios (ORs) found no statistically significant between-treatment differences in outcomes. In RCT meta-analyses, no statistically significant between-treatment differences were observed for death (OR [95% confidence interval], 1.35 [0.98–1.86]), bronchopulmonary dysplasia (1.25 [0.96–1.62]), pneumothorax (1.21 [0.72–2.05]), and air leak syndrome (2.28 [0.82–6.39]). Collectively, outcomes were similar with beractant and poractant alfa in RWE studies and pooled RCTs.
Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo
Authors: Du Guifang , Wang Jing , Zhang Ting , Ding Qiang , Jia Xiaodong , Zhao Xueke , Dong Jinke , Yang Xinrui , Lu Shanshan , Zhang Cuihong , Liu Ze , Zeng Zhen , Safadi Rifaat , Qi Ruizhao , Zhao Xin , Hong Zhixian , Lu Yinying 
Published: February 2020

AbstractRecent studies suggest that Src family kinase (SFK) plays important roles in systemic sclerosis and pulmonary fibrosis. However, how SFKs contributed to the pathogenesis of liver fibrosis remains largely unknown. Here, we investigated the role of Fyn, a member of SFK, in hepatic stellate cell (HSC) activation and liver fibrosis, and evaluated the anti-fibrotic effects of Saracatinib, a clinically proven safe Fyn inhibitor. Fyn activation was examined in human normal and fibrotic liver tissues. The roles of Fyn in HSC activation and liver fibrosis were evaluated in HSC cell lines by using Fyn siRNA and in Fyn knockout mice. The effects of Saracatinib on HSC activation and liver fibrosis were determined in primary HSCs and CCl4 induced liver fibrosis model. We showed that the Fyn was activated in the liver of human fibrosis patients. TGF-β induced the activation of Fyn in HSC cell lines. Knockdown of Fyn significantly blocked HSC activation, proliferation, and migration. Fyn deficient mice were resistant to CCl4 induced liver fibrosis. Saracatinib treatment abolished the activation of Fyn, downregulated the Fyn/FAK/N-WASP signaling in HSCs, and subsequently prevented the activation of HSCs. Saracatinib treatment significantly reduced the severity liver fibrosis induced by CCl4 in mice. In conclusions, our findings supported the critical role of Fyn in HSC activation and development of liver fibrosis. Fyn could serve as a promising drug target for liver fibrosis treatment. Fyn inhibitor Saracatinib significantly inhibited HSC activation and attenuated liver fibrosis in mouse model.