bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unconstrained Vital Sign Monitoring System Using an Aortic Pulse Wave Sensor
Authors: Hagiyama Naoki , Hirano Harutoyo , Mito Akihisa , Soh Zu , Fujita Etsunori , Ogura Yumi , Kaneko Shigehiko , Nakamura Ryuji , Saeki Noboru , Kawamoto Masashi , Yoshizumi Masao , Tsuji Toshio 
Published: November 2019

AbstractThis paper proposes a novel unconstrained monitoring system that measures heart and respiratory rates and evaluates autonomic nervous activity based on heart rate variability. The proposed system measures the aortic pulse waves (APWs) of a patient via an APW sensor that comprises a single microphone integrated into a mattress. Vital signs (i.e., heart rate, respiratory rate) and autonomic nervous activity were analyzed using the measured APWs. In an experiment with supine and seated participants, vital signs calculated by the proposed system were compared with vital signs measured with commercial devices, and we obtained the correlations of r > 0.8 for the heart rates, r > 0.7 for the respiratory rates, and r > 0.8 for the heart rate variability indices. These results indicate that the proposed system can produce accurate vital sign measurements. In addition, we performed the experiment of image stimulus presentation and explored the relationships between the self-reported psychological states evoked by the stimulus and the measured vital signs. The results indicated that vital signs reflect psychological states. In conclusion, the proposed system demonstrated its ability to monitor health conditions by actions as simple as sitting or lying on the APW sensor.
Kisspeptin-Activated Autophagy Independently Suppresses Non-Glucose-Stimulated Insulin Secretion from Pancreatic β-Cells
Authors: Huang Chien , Wang Hao-Yi , Wang Mu-En , Hsu Meng-Chieh , Wu Yi-Hsieng Samuel , Jiang Yi-Fan , Wu Leang-Shin , Jong De-Shien , Chiu Chih-Hsien 
Published: November 2019

AbstractPrevious studies have demonstrated the important role of kisspeptin in impaired glucose-stimulated insulin secretion (GSIS). In addition, it was reported that the activation of autophagy in pancreatic β-cells decreases insulin secretion by selectively degrading insulin granules. However, it is currently unknown whether kisspeptin suppresses GSIS in β-cells by activating autophagy. To investigate the involvement of autophagy in kisspeptin–regulated insulin secretion, we overexpressed Kiss1 in NIT-1 cells to mimic the long-term exposure of pancreatic β-cells to kisspeptin during type 2 diabetes (T2D). Interestingly, our data showed that although kisspeptin potently decreases the intracellular proinsulin and insulin ((pro)insulin) content and insulin secretion of NIT-1 cells, autophagy inhibition using bafilomycin A1 and Atg5 siRNAs only rescues basal insulin secretion, not kisspeptin-impaired GSIS. We also generated a novel in vivo model to investigate the long-term exposure of kisspeptin by osmotic pump. The in vivo data demonstrated that kisspeptin lowers GSIS and (pro)insulin levels and also activated pancreatic autophagy in mice. Collectively, our data demonstrated that kisspeptin suppresses both GSIS and non-glucose-stimulated insulin secretion of pancreatic β-cells, but only non-glucose-stimulated insulin secretion depends on activated autophagic degradation of (pro)insulin. Our study provides novel insights for the development of impaired insulin secretion during T2D progression.
Altered processing enhances the efficacy of small-diameter silk fibroin vascular grafts
Authors: Chan Alex H. P. , Filipe Elysse C. , Tan Richard P. , Santos Miguel , Yang Nianji , Hung Juichien , Feng Jieyao , Nazir Sidra , Benn Alexander J. , Ng Martin K. C. , Rnjak-Kovacina Jelena , Wise Steven G. 
Published: November 2019

AbstractCurrent synthetic vascular grafts are not suitable for use in low-diameter applications. Silk fibroin is a promising natural graft material which may be an effective alternative. In this study, we compared two electrospun silk grafts with different manufacturing processes, using either water or hexafluoroisopropanol (HFIP) as solvent. This resulted in markedly different Young’s modulus, ultimate tensile strength and burst pressure, with HFIP spun grafts observed to have thicker fibres, and greater stiffness and strength relative to water spun. Assessment in a rat abdominal aorta grafting model showed significantly faster endothelialisation of the HFIP spun graft relative to water spun. Neointimal hyperplasia in the HFIP graft also stabilised significantly earlier, correlated with an earlier SMC phenotype switch from synthetic to contractile, increasing extracellular matrix protein density. An initial examination of the macrophage response showed that HFIP spun conduits promoted an anti-inflammatory M2 phenotype at early timepoints while reducing the pro-inflammatory M1 phenotype relative to water spun grafts. These observations demonstrate the important role of the manufacturing process and physical graft properties in determining the physiological response. Our study is the first to comprehensively study these differences for silk in a long-term rodent model.
Persistence of single species of symbionts across multiple closely-related host species
Authors: Doña Jorge , Osuna-Mascaró Carolina , Johnson Kevin P. , Serrano David , Aymí Raül , Jovani Roger 
Published: November 2019

AbstractSome symbiont species are highly host-specific, inhabiting only one or a very few host species, and typically have limited dispersal abilities. When they do occur on multiple host species, populations of such symbionts are expected to become genetically structured across these different host species, and this may eventually lead to new symbiont species over evolutionary timescales. However, a low number of dispersal events of symbionts between host species across time might be enough to prevent population structure and species divergence. Overall, processes of evolutionary divergence and the species status of most putative multi-host symbiont systems are yet to be investigated. Here, we used DNA metabarcoding data of 6,023 feather mites (a total of 2,225 OTU representative sequences) from 147 infracommunities (i.e., the assemblage consisting of all mites of different species collected from the same bird host individual) to investigate patterns of population genetic structure and species status of three different putative multi-host feather mite speciesProctophyllodes macedoVitzthum, 1922,Proctophyllodes motacillaeGaud, 1953, andTrouessartia jedliczkai(Zimmerman, 1894), each of which inhabits a variable number of different closely related wagtail host species (genusMotacilla). We show that mite populations from different host species represent a single species. This pattern was found in all the mite species, suggesting that each of these species is a multi-host species in which dispersal of mites among host species prevents species divergence. Also, we found evidence of limited evolutionary divergence manifested by a low but significant level of population genetic structure among symbiont populations inhabiting different host species. Our study agrees with previous studies showing a higher than expected colonization opportunities in host-specific symbionts. Indeed, our results support that these dispersal events would allow the persistence of multi-host species even in symbionts with limited dispersal capabilities, though additional factors such as the geographical structure of some bird populations may also play a role.
Ancient mitogenomics clarifies radiation of extinct Mascarene giant tortoises (Cylindraspis spp.)
Authors: Kehlmaier Christian , Graciá Eva , Campbell Patrick D. , Hofmeyr Margaretha D. , Schweiger Silke , Martínez-Silvestre Albert , Joyce Walter , Fritz Uwe 
Published: November 2019

AbstractThe five extinct giant tortoises of the genus Cylindraspis belong to the most iconic species of the enigmatic fauna of the Mascarene Islands that went largely extinct after the discovery of the islands. To resolve the phylogeny and biogeography of Cylindraspis, we analysed a data set of 45 mitogenomes that includes all lineages of extant tortoises and eight near-complete sequences of all Mascarene species extracted from historic and subfossil material. Cylindraspis is an ancient lineage that diverged as early as the late Eocene. Diversification of Cylindraspis commenced in the mid-Oligocene, long before the formation of the Mascarene Islands. This rejects any notion suggesting that the group either arrived from nearby or distant continents over the course of the last millions of years or had even been translocated to the islands by humans. Instead, Cylindraspis likely originated on now submerged islands of the Réunion Hotspot and utilized these to island hop to reach the Mascarenes. The final diversification took place both before and after the arrival on the Mascarenes. With Cylindraspis a deeply divergent clade of tortoises became extinct that evolved long before the dodo or the Rodrigues solitaire, two other charismatic species of the lost Mascarene fauna.
Antimicrobial activity of Titanium dioxide and Zinc oxide nanoparticles supported in 4A zeolite and evaluation the morphological characteristic
Authors: Azizi-Lalabadi Maryam , Ehsani Ali , Divband Baharak , Alizadeh-Sani Mahmood 
Published: November 2019

AbstractIn this study, the antimicrobial activity of titanium dioxide (TiO2), zinc oxide (ZnO), and TiO2/ZnO nanoparticles supported into 4A zeolite (4A z) was assessed. Based on antimicrobial experiments, minimum inhibitory concentration (MIC90), minimum bactericidal concentration (MBC), fractional inhibitory concentration (FIC) and disc diffusion test were determined after 24 h of contact with the prepared nanocomposites. These results are in agreements with the results of disc diffusion test. During the experiments, the numbers of viable bacterial cells of Staphylococcus aureus, Pseudomonas fluorescens, Listeria monocytogenes and Escherichia coli O157:H7 decreased significantly. The crystallinity and morphology of nanoparticles were investigated by X-ray diffraction patterns (XRD), elemental mapping at the microstructural level by scanning electron microscopy (SEM) with energy dispersive X-ray spectrometry (EDS), and transmission electron microscopy (TEM). As a result, it was demonstrated that TiO2/ZnO nanoparticles supported in 4A zeolite could lead to an optimum activity as antimicrobial agents.
Inhibition of microRNA-146a attenuated heart failure in myocardial infarction rats
Authors: He Junjie , Lu Ying , Song Xiaozheng , Gong Xiaoxuan , Li Yong 
Published: November 2019

Abstract
The aim of the present study was to determine the roles of microRNA (miR)-146a on myocardial infarction (MI)-induced heart failure and cardiac remodeling. Experiments were carried out in Sprague-Dawley rats treated with ligation of left coronary artery to induce heart failure, and in primary neonatal rat cardiac fibroblasts (CFs) and cardiomyocytes treated with angiotensin (Ang) II. Four weeks after MI, rats were injected with miR-146a antagomiR or agomiR via tail vein. After 2 weeks of injection, the rats were killed. In MI rats, left ventricle (LV) ejection fraction and fractional shortening were reduced, and LV volumes in diastole and systole were increased, which were reversed by miR-146a antagomiR, and further exacerbated after miR-146a agomiR treatment. Administration of miR-146a antagomiR improved the decreases of LV ±dp/dtmax and LV systolic pressure (LVSP), and the increase in LV end-diastolic pressure (LVEDP) of MI rats, but miR-146a agomiR deteriorated the LV ±dp/dtmax, LVSP and LVEDP. The increases in the levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), collagen I and collagen III in the heart, and ST2 and norepinephrine in the serum of MI rats were inhibited by miR-146a antagomiR, but aggravated after miR-146a agomiR treatment. The increases of collagen I and collagen III levels induced by Ang II in CFs, and the increases of ANP and BNP levels induced by Ang II in cardiomyocytes were inhibited by miR-146a antagomiR, but aggravated by miR-146a agomiR. These results demonstrated that inhibition of miR-146a improved cardiac dysfunction and cardiac remodeling in heart failure rats.
Des peintures des Primitifs flamands à l’impression 3D. Comment jouer avec des couches colorées translucides ?
Authors: Simonot Lionel 
Published: November 2019

Avec l’invention de la peinture à l’huile au XVe siècle, la couleur prend une autre dimension : elle se construit dans l’épaisseur de la matière picturale. En effet, le nombre de couches déposées module la clarté et la saturation de la couleur, tandis qu’un fond blanc diffusant donne l’impression d’une lumière provenant de l’arrière du tableau tel un rétro-éclairage.
Étudier la matière picturale comme un composant optique permet de simuler l’apparence d’un tableau, aide qui peut être précieuse lors d’une opération de restauration sur les couches picturales.
Cette approche est aussi à la source de procédés innovants d’impression 3D couleur s’inspirant de la technique des peintres de la Renaissance.
Quand les muons cosmiques explorent le cœur de la matière
Authors: Procureur Sébastien 
Published: November 2019

L’utilisation de techniques non destructives est souvent une nécessité en archéologie, mais leur mise en pratique peut parfois être délicate. C’est particulièrement le cas de grandes structures qui sont par nature non transportables, exigeant une technologie mobile et des sondes pénétrantes.
La muographie répond parfaitement à ce type de besoins, en utilisant des particules très énergétiques issues du rayonnement cosmique naturel. Grâce à des instruments développés pour la physique des hautes énergies, cette technique permet aujourd’hui de sonder des endroits inaccessibles et inexplorés avec une précision inédite. La découverte récente de plusieurs cavités à l’intérieur de la pyramide de Khéops le démontre : les muons peuvent voir (presque) partout.
Significant factors of violence against women in urban and rural community
Authors: Rusnakova Marketa , Huskova L'udmila 
Published: November 2019

Introduction. The research is focused on the issue of domestic violence against women. It deals with the definition of violence, concepts and models of individual areas by summarising the research findings and the possibilities of methodological tools for measurement of significant factors of violence against women. Aim. The primary goal of the research is to define significant factors which determine violence against women. Materialand Methods. Methods of research – survey, document analysis and database statistical analysis. Results. Primary results of quantitative research reveal that women of all ages and educational groups are at risk. Mostly women aged 26–45, living in rural areas with middle school education without maturity exam (final exam). Violence in families involves men of all age groups with emphasis on increased incidence in specific categories: mostly men aged 36–45, living in rural areas with secondary (high school or comprehensive school) education. Another field of interest represents analysis of negative family situations, impact of violence against woman on her psychological conditions, and reasons why victims carry on marriage and/or partnership. Conclusions. It can be concluded that the most frequent negative phenomena during aggressor's and/or victim's childhood were physical violence of father against mother, alcohol – possibly father's alcoholism, poverty, physical punishment of children, and patriarchal model of the family. Two thirds of victims continue marriage/partnership in order to maintain the family, to keep the father for children, and for financial reasons. There is a frequent social criminality in poor biological families of aggressors, i.e., a commission of crime because of lack of finances.
The “Twist-Needle” – a new concept for endoscopic ultrasound-guided fine needle-biopsy
Authors: Hann Alexander , Walter Benjamin M. , Epp Sonja , Ayoub Younan Kabara , Meining Alexander 
Published: November 2019

Abstract
Background and study aims Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) represents a standard method for tissue acquisition of lesions adjacent to the gastrointestinal wall. Needles of 19 gauge acquire more tissue than needles with a smaller diameter, but are often unable to penetrate solid, rigid masses. In this study we evaluated a novel prototype that links forward movement of the needle to rotation of the needle tip.
Materials and methods Two needle-models that generate either a regular axial movement or a combination of axial movement with rotation of the needle tip were compared ex vivo for measurement of pressure needed to penetrate artificial tissue. Furthermore, a standard 19-gauge EUS-FNB needle was compared to a modified model (“Twist Needle”) in an ex vivo model to measure the amount of tissue obtained.
Results Pressure measurements using the rotating needle revealed that significantly less pressure is needed for penetration compared to the regular axial movement (mean ± SEM; 3.7 ± 0.3 N vs. 5.5 ± 0.3 N). Using the modified 19-gauge “Twist Needle” did not diminish tissue acquisition measured by surface amount compared to a standard needle (37 ± 5 mm² vs. 35 ± 6 mm²).
Conclusion The method of rotation of an EUS-FNB needle tip upon forward movement requires less pressure for penetration but does not diminish tissue acquisition. Hence, the concept of our “Twist Needle” may potentially reduce some of the current limitations of standard EUS-FNB.
Zuhören, wertschätzen, Sinn finden
Authors: Gebhardt Stefan 
Published: November 2019

ZusammenfassungDamit psychisch erkrankte Menschen nicht in ein Versorgungssystem gepresst werden, das ihren Bedürfnissen widerspricht, ist es wichtig, ihre Lebenswelt mit in die Behandlung zu integrieren. Dabei können Pflegende von Betroffenen lernen, was zu tun ist – statt die Betroffenen anzuleiten, wie man etwas macht. Unser Autor stellt Behandlungskonzepte – wie das Gezeiten-Modell, das Transtheoretische Modell, Recovery und Motivational Interviewing – vor, die die individuellen Bedürfnisse der Patienten beachten und ihnen helfen, im Recovery-Prozess voranzuschreiten.
Fallbesprechungen in der Gerontopsychiatrie nach dem Wittener Modell
Authors: Blumenrode Stefan 
Published: November 2019

ZusammenfassungHerausforderndes Verhalten ist bei Menschen mit Demenz keine Seltenheit. Um angemessen damit umgehen zu können, wurde das Wittener Modell der Fallbesprechung bei Menschen mit Demenz entwickelt. Mit dieser Methode gelingt es Pflegenden, herausforderndes Verhalten besser zu verstehen, Handlungsoptionen zu entwickeln und so zum Wohlbefinden des Menschen mit Demenz beizutragen.
Supercritical Extracts from Arctium lappa as a Potential Inhibitor for the Activation of Complement System
Authors: Fontana Pâmela Dias , Bavia Lorena , Bovo Fernanda , Souza Ariádine Reder C. de , Corazza Marcos Lúcio , Messias-Reason Iara Jose 
Published: November 2019

Abstract
Arctium lappa is a perennial species of the Asteraceae family originally from Europe and Asia. Considered a weed species in the southern region of Brazil, it is popularly used as a natural anti-inflammatory. The complement system is an important component of the innate immune response. However, its exacerbated activation can lead to harmful conditions like autoimmune and inflammatory disorders. Plants that inhibit the activation of complement can be a promising tool in the treatment of inflammatory diseases. Here, we evaluated the effect of A. lappa leaves extracts on the activation of the classical and alternative pathways of complement system. Two extracts were obtained under supercritical conditions using scCO2 with ethanol as cosolvent, at 313.15K, 15 MPa (E1) and 25 MPa (E2). Classical and alternative activation were evaluated using complement fixation test. Different concentrations of A. lappa extracts E1 and E2 showed an inhibitory effect on both complement pathways, and heparin was used as control. The IC50 of E1, E2, and heparin were 28.26, 20.12 and 92.54 µg/mL for classical and 26.12, 27.70, 27.78 µg/mL for the alternative pathway. Results demonstrate that A. lappa is a promising complementary treatment for diseases associated with complement activation.
Development and Validation of a UHPLC-PDA-MS Method for the Quantitative Analysis of Anthraquinones in Bulbine natalensis Extracts and Dietary Supplements
Authors: Bae Ji-Yeong , Avula Bharathi , Wang Yan-Hong , Wang Mei , Ali Zulfiqar , Viljeon Alvaro M. , Khan Ikhlas A. 
Published: November 2019

AbstractA UHPLC-photodiode array-MS method was developed and validated for the quantification of one chromone and six anthraquinone type of compounds from Bulbine natalensis plant samples and dietary supplements. Metabolites
1 –
7 were identified based on their retention times and electrospray ionization-MS spectra compared with a mix of previously isolated compounds. The quantification of
1 –
7 was based on photodiode array detection. The optimized separation was achieved using a CORTECS C18 column with a gradient of water/acetonitrile as the mobile phase. Seven compounds were separated within 15 minutes with detection limits of 50 pg on the column. The analytical method was validated for linearity, repeatability, accuracy, limits of detection, and limits of quantification. The relative standard deviations for intra- and inter-day experiments were less than 5% and the recovery efficiency was 98 – 101%. Nine dietary supplements labeled as containing B. natalensis were examined. Anthraquinone-type compounds were detected in only five out of nine dietary supplements, with the total amount ranging from 11.3 to 90.4 mg per daily dose. The analytical method is simple, economic, rapid, and can be applied for quality assessment of B. natalensis and dietary supplements. Electrospray ionization-MS was used for the identification of these compounds in plant samples and dietary products.
Translation and Translatio in the New Rhetoric Project’s Rediscovery of Rhetoric
Authors: Bolduc Michelle 
Published: November 2019

ABSTRACT
This article, an excerpt from my forthcoming book, Translation and the Rediscovery of Rhetoric, traces the surprising role of translation and of translatio (the medieval trope referring to the transfer of knowledge across time and space) in the story of Chaïm Perelman and Lucie Olbrechts-Tyteca’s turn to rhetoric. Neither Perelman nor Olbrechts-Tyteca were well versed in the French tradition of rhetoric as poetics. However, in two lectures Perelman gave late in his life, he offered a surprising description of the influence of Jean Paulhan, the French literary critic and long-time director of the Nouvelle Revue française, and of thirteenth-century Italian author and notary Brunetto Latini, on the turn to rhetoric. In addition, this essay situates these lectures as a critical response to the claim made by three important French thinkers, Paul Ricoeur, Roland Barthes, and Gérard Genette, that they had recovered rhetoric for the study of expression and thus as poetics.