bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteonecrosis in sickle cell disease: an update on risk factors, diagnosis, and management
Authors: Adesina Oyebimpe O. , Neumayr Lynne D. 
Published: December 2019

Abstract
Osteonecrosis, a form of ischemic bone injury that leads to degenerative joint disease, affects ∼30% of people with sickle cell disease. Although osteonecrosis most commonly affects the femoral head (often bilaterally, with asymmetric clinical and radiographic progression), many people with sickle cell disease also present with multifocal joint involvement. We present the case of a young woman with bilateral osteonecrosis of the femoral head at varying stages of progression; we also highlight other important comorbid complications (eg, chronic pain requiring long-term opioids, debility, and social isolation) and postoperative outcomes. In this review, partly based on recommendations on osteonecrosis management from the 2014 evidence-based report on sickle cell disease from the National Heart, Lung and Blood Institutes, we also discuss early signs or symptoms of osteonecrosis of the femoral head, radiographic diagnosis and staging criteria, hydroxyurea effect on progression to femoral head collapse, and surgical outcomes of total hip arthroplasty in the modern era. In summary, we failed to find an association between hydroxyurea use and femoral head osteonecrosis; we also showed that evidence-based perioperative sickle cell disease management resulted in superior postoperative outcomes after cementless total hip arthroplasty in sickle cell–related osteonecrosis of the femoral head.
Lowering the boom on lower-risk myelodysplastic syndromes
Authors: Sekeres Mikkael A. , Patel Bhumika J. 
Published: December 2019

Abstract
Lower-risk myelodysplastic syndromes are defined using prognostic scoring systems that incorporate data on bone marrow blast percentage, degree and numbers of cytopenias, and cytogenetic abnormalities. Increasingly, these are incorporating molecular abnormalities to further refine risk. Therapy is geared toward predominating cytopenias, with erythropoiesis-stimulating agents luspatercept and lenalidomide used to ameliorate anemia, romiplostim and eltrombopag tackling thrombocytopenia, and hypomethylating agents and antithymocyte globulin palliating pancytopenia. Newer agents on the horizon are abrogating the downstream sequelae of specific molecular mutations. One challenge for the future is in further modifying response criteria to align with improvements that are clinically meaningful to patients.
Improvements in diagnosis and risk assessment of primary and secondary antiphospholipid syndrome
Authors: Petri Michelle 
Published: December 2019

AbstractClassification criteria for antiphospholipid syndrome have not been updated since the revised Sapporo classification criteria were published in 2006. These criteria have limitations in that they omit nonclassical manifestations (hematologic and neurologic), include anticardiolipin and anti–β2-glycoprotein I immunoglobulin (Ig)M isotypes, and do not separately consider primary (no autoimmune disease) or secondary (usually systemic lupus erythematosus) disease. Recent findings in antiphospholipid antibody include fluctuation of antiphospholipid antibodies, recognition that IgA isotypes do confer risk, identification of the role of complementopathy in catastrophic antiphospholipid syndrome, and elucidation of the role of thrombosis risk equations.
Preoperative anemia-screening clinics
Authors: Lin Yulia 
Published: December 2019

AbstractPreoperative anemia is associated with increased postoperative morbidity and mortality and with increased risk of perioperative transfusion. It is an important and modifiable risk factor for surgical patients. For high-blood-loss surgery, preoperative anemia is defined as hemoglobin &lt;13 g/dL for both male and female patients. Preoperative anemia is common, ranging from 25% to 40% in large observational studies. The most common treatable cause of preoperative anemia is iron-deficiency anemia; the initial laboratory tests should focus on making this diagnosis. Management of iron-deficiency anemia includes iron supplementation with IV iron therapy when oral iron is ineffective or not tolerated, there is severe anemia, and there is insufficient time to surgery (&lt;4 weeks). In other situations, erythropoiesis-stimulating agents may be considered, particularly for those patients with multiple alloantibodies or religious objections to transfusion. To facilitate the diagnosis and management of preoperative anemia, establishment of preoperative anemia-screening clinics is essential. The goals of management of preoperative anemia are to treat anemia, reduce the need for transfusion, and improve patient outcomes.
Clinical decision support and improved blood use in patient blood management
Authors: Goodnough Lawrence Tim , Hollenhorst Marie A. 
Published: December 2019

Abstract
Despite many years of published medical society guidelines for red blood cell (RBC) transfusion therapy, along with clinical trials that provide Level 1 evidence that restrictive transfusion practices can be used safely and are equivalent to transfusions given more liberally, annualized blood transfusion activity did not begin to decline in the United States until 2010. Adoption of electronic medical records has subsequently allowed implementation of clinical decision support (CDS): best practice alerts that can be initiated to improve the use of blood components. We describe our own institutional experience using a targeted CDS to promote restrictive blood transfusion practice and to improve RBC use. A 42% reduction in RBC transfusions was demonstrated at our institution from a baseline in 2008 through 2015, and the rate remained stable through 2018. Although the data cannot be used to infer causality, this decreased RBC use was accompanied by improved clinical outcomes.
Opportunities for immunotherapy in childhood acute myeloid leukemia
Authors: Lamble Adam J. , Tasian Sarah K. 
Published: December 2019

AbstractClinical outcomes for children with acute myeloid leukemia (AML) have improved minimally during the past 4 decades despite maximally intensive chemotherapy, hematopoietic stem cell transplantation, and optimized supportive care. Chemoresistance and relapse remain major sources of childhood cancer–associated mortality and highlight the need for alternative treatment approaches. The remarkable recent success of humoral and cellular immunotherapies in children and adults with relapsed/refractory B-acute lymphoblastic leukemia has inspired hope for similar accomplishments in patients with AML. However, unique challenges exist, including the biologic and immunophenotypic heterogeneity of childhood AML and the significant potential for on-target/off-tumor immunotherapeutic toxicity due to target antigen expression on nonmalignant cells. This article reviews the current landscape of antibody-based and cellular immunotherapies under current clinical evaluation with an emphasis on active or soon-to-open phase 1 trials for children with relapsed/refractory AML.
Cutting-based single atomic layer removal mechanism of monocrystalline copper: edge radius effect
Authors: Xie Wenkun , Fang Fengzhou 
Published: December 2019

AbstractThe ultimate objective of mechanical cutting is to down minimum chip thickness to single atomic layer. In this study, the cutting-based single atomic layer removal mechanism on monocrystalline copper is investigated by a series of molecular dynamics analysis. The research findings report that when cutting depth decreases to atomic scale, minimum chip thickness could be down to single atomic layer by mechanical cutting using rounded edge tool. The material removal behaviour during cutting-based single atomic layer removal exhibits four characteristics, including chip formation by shearing-stress driven dislocation motion, elastic deformation on the processed surface, atomic sizing effect, and cutting-edge radius effect. Based on this understanding, a new cutting model is proposed to study the material removal behaviour in cutting-based single atomic layer removal process, significantly different from those for nanocutting and conventional cutting. The outcomes provide theoretical support for the research and development of the atomic and close-to-atomic scale manufacturing technology.
Variation in species assemblages due to micro-topography and flow regime govern vegetation carbon stock in seasonal floodplain wetlands
Authors: Sarkar Priyanka , Das Tapati , Adhikari Dibyendu 
Published: December 2019

Abstract
Hypothesis
Variation in species assemblages due to micro-topographic features and flow regime determine vegetation carbon stock in floodplain wetlands.

Material and method
We tested this hypothesis in Chatla—a tropical floodplain wetland located in northeast India. Five sampling stations characterized by contrasting micro-topographic and flow parameters were selected in the wetland for study. Species composition, assemblage pattern, and vegetation carbon stock were studied in these stations during three flood phases, i.e., early, middle, and late flood phases following standard methods. Univariate and multivariate statistics were used to determine the relationship between the selected environmental parameters, plant species assemblages, and vegetation carbon stock of the wetland.

Results
Thirty-one species of herbs and five species of shrubs were recorded from the five stations in Chatla floodplain wetland. Flow regime characterized by water flow velocity and discharge showed substantial variations across the stations. These parameters in turn are related to variations in the micro-topographic characteristics namely depth, width, and cross-sectional area of the stations. Plant species composition and abundance differed significantly with respect to micro-topography and flow regime as revealed by the cluster diagram. The canonical correspondence analysis revealed strong association of plant species assemblages with the micro-topography and flow regime within the wetland. Multiple regression analysis revealed a significant positive relationship of the vegetation carbon stock with the water discharge.

Conclusions
Spatial variation in plant species diversity because of micro-topography and flow regime determines the vegetation carbon stock in floodplain wetlands. Modification of these parameters by anthropogenic activities such as mining and quarrying may potentially influence the carbon stocking potential of seasonal floodplain wetlands. Therefore, appropriate measures should be taken to maintain the integrity of the natural topographic features of such wetlands.
Composition of camel milk and evaluation of food supply for camels in Uzbekistan
Authors: Pak Valeriy V. , Khojimatov Olim K. , Abdiniyazova Gulnara J. , Magay Elena B. 
Published: December 2019

Abstract
Background
In Uzbekistan, local people consumed camel milk products since ancient time. Camel milk is a source of energy and nutrients which are consumed as raw or fermented products and also provides various potential health benefits for human.

Methods
The data were collected during 2016–2018 by expeditions in desert and semi-desert regions of Uzbekistan. Three hundred sixty sheets of plants have been collected from those regions. Forty-two samples of raw camel milk were collected at two periods of the year: 21 samples during summer (June, July, and August) and 21 during winter (December, January, and February).

Results and discussion
Analysis of the composition of camel milk samples revealed the particular richness of camel milk in protein and fat content. Average values of protein and fat were found as 4.04 ± 0.36% w/v and 4.89 ± 0.26% w/v, respectively. Analysis of the composition of camel milk showed that protein, fat, and dry matter contents were comparatively lower in the summer period. Also, it was found that the average values of all components decreased from December to February and had a tendency to grow from June to August. This finding suggests a seasonal variation in available food supply. Investigation of an available fodder flora revealed that a fodder base consists of around 300 plants. Analysis of plant species revealed that 30 plants were widely used in traditional medicine.

Conclusion
Our results suggested that the healing benefit of camel milk can be connected with higher content of proteins including the various protective proteins and with secretion of the bioactive compounds from plants with medicinal properties via food.
Modelling and control of solar-driven humidification–dehumidification desalination plant
Authors: Gabra Bahy , Rady Mohamed , Abdel Ghany A. M. , Shamseldin Mohamed. A. 
Published: December 2019

AbstractThis article reports on mathematical modelling and control of a solar-driven humidification–dehumidification desalination plant. Mathematical models for the components are constructed using CARNOT toolbox in MATLAB environment. Model validation has been shown by comparison with published experimental data. Solar collector outlet temperature control is a key parameter to optimize plant performance. In this study, solar field pump flow rate is controlled to maintain the collector outlet temperature at a predetermined set value. Three types of PID controllers are tested. These include PID, nonlinear PID and fractional-order PID. Controllers’ gains are optimized using genetic algorithm technique. The results show that FOPID controller offers a superior dynamic and static performance and can be automatically adjusted to compensate for weather changes.
Osimertinib in Patients With Epidermal Growth Factor Receptor Mutation–Positive Non–Small-Cell Lung Cancer and Leptomeningeal Metastases: The BLOOM Study
Authors: Yang James C.H. , Kim Sang-We , Kim Dong-Wan , Lee Jong-Seok , Cho Byoung Chul , Ahn Jin-Seok , Lee Dae H. , Kim Tae Min , Goldman Jonathan W. , Natale Ronald B. , Brown Andrew P. , Collins Barbara , Chmielecki Juliann , Vishwanathan Karthick , Mendoza-Naranjo Ariadna , Ahn Myung-Ju 
Published: December 2019

PURPOSE In this phase I study (BLOOM), osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), was evaluated in patients with leptomeningeal metastases (LMs) from EGFR-mutated (EGFRm) advanced non–small-cell lung cancer (NSCLC) whose disease had progressed on previous EGFR-TKI therapy. PATIENTS AND METHODS Patients with cytologically confirmed LM received osimertinib 160 mg once daily. Objectives were to assess confirmed objective response rate (ORR), duration of response (DoR), progression-free survival (PFS), overall survival (OS), pharmacokinetics (PK), and safety. Additional efficacy evaluations included changes from baseline in CSF cytology and neurologic examination. Measurable lesions were assessed by investigator according to RECIST version 1.1. LMs were assessed by neuroradiologic blinded central independent review (BICR) according to Response Assessment in Neuro-Oncology LM radiologic criteria and by investigator. RESULTS Forty-one patients were enrolled. LM ORR and DoR by neuroradiologic BICR were 62% (95% CI, 45% to 78%) and 15.2 months (95% CI, 7.5 to 17.5 months), respectively. Overall, ORR by investigator was 41% (95% CI, 26% to 58%), and median DoR was 8.3 months (95% CI, 5.6 to 16.5 months). Median investigator-assessed PFS was 8.6 months (95% CI, 5.4 to 13.7 months) with 78% maturity; median OS was 11.0 months (95% CI, 8.0 to 18.0 months) with 68% maturity. CSF tumor cell clearance was confirmed in 11 (28%; 95% CI, 15% to 44%) of 40 patients. Neurologic function was improved in 12 (57%) of 21 patients with an abnormal assessment at baseline. The adverse event and PK profiles were consistent with previous reports for osimertinib. CONCLUSION Osimertinib showed meaningful therapeutic efficacy in the CNS and a manageable safety profile at 160 mg once daily in patients with EGFRm NSCLC and LM.
Genomic Profiling for KRAS, NRAS, BRAF, Microsatellite Instability, and Mismatch Repair Deficiency Among Patients With Metastatic Colon Cancer
Authors: Gutierrez Martin E. , Price Kristin S. , Lanman Richard B. , Nagy Rebecca J. , Shah Irfan , Mathura Shivam , Mulcahy Michael , Norden Andrew D. , Goldberg Stuart L. 
Published: December 2019

PURPOSE Genomic testing is recognized in national guidelines as essential to guide appropriate therapy selection in metastatic colorectal cancer. Previous studies report adherence to testing guidelines is suboptimal, but current testing rates have not been assessed. This study reports testing rates in metastatic colon cancer (mCC) for guideline-recommended biomarkers in a US-based population. MATERIALS AND METHODS A retrospective review of data extracted from electronic medical records was performed to identify patients with pathologically confirmed mCC and describe patterns of guideline-aligned biomarker testing. Data were extracted from the electronic health records of 1,497 patients treated at 23 practices across the United States. Both community and academic centers were represented. RESULTS A total of 1,497 patients with mCC diagnosed between January 1, 2013 and December 31, 2017 were identified. Guideline-aligned biomarker testing rates for RAS, BRAF, and microsatellite instability/mismatch repair deficiency over this study period were 41%, 43%, and 51%, respectively. Patients were more likely to have guideline-aligned testing for RAS and BRAF if they were treated at an academic center, were diagnosed with de novo metastatic disease, and were female. In addition, patients < 65 years of age were more likely to have guideline-aligned RAS testing. Of the 177 patients (12% of cohort) who received anti–epidermal growth factor receptor therapy, only 50 (28%) had complete guideline-aligned biomarker testing. CONCLUSION Despite guideline recommendations and significant therapeutic implications, overall biomarker testing rates in mCC remain suboptimal. Adherence to guideline-recommended biomarker testing would potentially reduce exposure to expensive and ineffective therapies, resulting in improved patient outcomes.
Epidemiology of viral hepatitis B and C in Punjab, Pakistan: a multicenter cross-sectional study, 2017-18
Authors: Khan Amjad , Afzal Saira , Yaqoob Aashifa , Fatima Razia , Ul Haq Mahboob , Junaid Khunsa , Nadir Abdul 
Published: December 2019

Background: Globally, approximately 240 million people are chronically infected with hepatitis B virus (HBV) and hepatitis C virus (HCV), which are responsible for 96% of all hepatitis-related mortality. Pakistan has the second highest prevalence of HCV in the world. Methods: We conducted this study to ascertain the prevalence and potential risk factors associated with HBV and HCV infections in Punjab. A multi-center cross-sectional study was conducted, involving 24 Hepatitis Prevention and Treatment Clinics of the Pakistan Kidney and Liver Institute and Research Center clinics, Lahore. A total of 141,705 individuals who visited the clinics during 2017-18 were included for seroprevalence analysis of hepatitis B (HBsAg) and C (Anti-HCV). In addition, 12,427 individuals from the main group underwent detailed face-to-face interviews based on a predesigned questionnaire for risk factor assessment. Results: The overall prevalence for HBV and HCV was 8.4% and 42.7%, respectively. Of those with HCV infection, 4.2% had a co-infection. The transgender population had a higher seroprevalence of HBV (11.8%) and HCV (58.8%). Higher HBV seroprevalence was found in a younger age group (16-30 years), while the older age group (>61 years) had a higher HCV seroprevalence. Geographically, Muzaffargarh district had the highest HBV seroprevalence at 26%, followed by Rajanpur district (20.3%). HCV seroprevalence was significantly (P value <0.05) higher in Shujabad district (66.4%), followed by Muzaffargarh (65.2%). Using multivariable logistic regression analysis, age, gender, intravenous injections, hijama therapy, dental procedure, circumcision by barbers, barber shaving, hospitalization and having had surgical procedures were all found to be significant risk factors (OR >1; p<0.05) for HBV and HCV. Conclusions: There is an urgent need for proper implementation of preventive and control strategies, as well as formal evaluation and monitoring mechanisms. Sustainable and adequate funding of public-sector hepatitis programs is also an extremely important area that should not be neglected.
Elliptical-spiral elliptical-hole photonic crystal fiber with high birefringence, large nonlinearity, and two zero dispersion
Authors: Zhang Shanshan , Shi Weiguang , Zhang Cheng , Shi Jia , Wu Jixuan , Li Hongqiang , Liu Yange , Zhang Bo 
Published: December 2019

This paper presents a soft-glass (SF-57) elliptical-spiral photonic crystal fiber with elliptical air holes for achieving high birefringence, large nonlinearity, and tailoring two zero-dispersion wavelengths (ZDWs) in the near-infrared region. A full-vector finite-element method with perfectly matched boundary layer is used to characterize the properties of the photonic crystal fiber for different ellipticity ratios. The designed fiber has a birefringence 4 times higher than the circular-spiral structure. There are two ZDWs at around 1.2 µm and 2.8 µm which can be finely tuned depending on the ellipticity ratios along with a large nonlinearity. Due to the superior guiding properties, the proposed structure can be used for polarization control and broadband supercontinuum generation.
Temperature-switchable mode selector in superconducting photonic crystals based on the Thue–Morse sequence
Authors: Hu Caixing , Zhang Haifeng , Ma Yu 
Published: December 2019

In this paper, a novel one-dimensional superconducting photonic crystal based on the quasi-periodic Thue–Morse (ThM) arrangement is theoretically investigated by the transfer matrix method, which can switch two transmission properties by controlling ambient temperature. Its transmission spectrum realizes omnidirectional photonic band gap (OBG) characteristics in low-temperature zones (about 10 K) and wide-angle broadband absorption characteristics in high-temperature zones (about 90 K) as the whole structure remains the same in the terahertz regime. The intrinsic reason for switchable functions can be ascribed to the superconducting negative permittivity that is dependent on both temperature and frequency under the superconducting state, which causes an OBG corresponding to the zero-averaged (volume) refractive index (zero-

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) and broadband absorption induced by high permittivity dissipation. From the numerical results, the OBG from the Bragg gap or absorption bandwidth can be notably tuned by manipulating the periodicity of the ThM sequence and dielectric or superconducting thicknesses. The effects of incident angle and polarization modes on the proposed structure are also considered. We report that the proposed structure has a preeminent zero-

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OBG ranging from 0.1 to 1.7 THz at 10 K and stable broadband absorption for a wide angle (at most 70 deg) in TM mode at 90 K, which provides theoretical guidance for the design and application of the temperature-switchable mode selector.