bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Perviousness to Plaque Imaging in Acute Basilar Occlusions
Authors: Berndt Maria T. , Pree David , Kaesmacher Johannes , Maegerlein Christian , Friedrich Benjamin , Zimmer Claus , Wunderlich Silke , Mück Fabian G. , Wirth Stefan , Boeckh-Behrens Tobias 
Published: January 2020

Background and Purpose—
Recent studies show that mechanical thrombectomy of acute basilar artery occlusions (BAO) results in high rates of successful recanalization and good outcomes, but predictors are not completely established yet. Varying occlusion types may benefit differently, and especially, an underlying basilar stenosis (BS) seems to have an impact. Aim of this study was to investigate angiographic and clinical differences in BAO subtypes and to test the potential of perviousness measures for a preinterventional identification of clinically relevant different occlusion types.

Methods—
All consecutive patients with acute BAO, endovascular treated at a single comprehensive stroke center, were included. Different occlusion patterns, especially underlying BS, were identified and analyzed in respect of angiographic and clinical (National Institutes of Health Stroke Scale/modified Rankin Scale) outcome parameters (N=115). Thrombus perviousness measures (change in thrombus attenuation Δt and corrected void fraction ε) were assessed in admission computed tomography imaging and correlated to different etiological subgroups.

Results—

Despite comparable rates of successful recanalization (87% for BAO with BS versus 95% without BS), the BS group showed worse clinical outcome with higher National Institutes of Health Stroke Scale/modified Rankin Scale values (
P
=0.002/0.003). The group of BS turned out to have lower thrombus density values in unenhanced scans (mean, 42.0 Hounsfield units) and higher perviousness measures Δt (mean, 34.6 Hounsfield units) and ε (mean, 0.23) than thrombi without an underlying BS (mean, 53.6 Hounsfield units/13.1 Hounsfield units/0.08,
P
=0.01/ 0.004/ 0.001).

Conclusions—
In agreement with previous studies, outcome of mechanical thrombectomy of BAO seems to depend on pathogenesis with less clinical benefit for underlying BS, raising the question of early identification of this subgroup. Perviousness showed a high potential to differentiate acute BAO with and without BS, possibly usable as an admission imaging marker for BS.
The Impurity of Stone Vessels in 11QTa and CD in Light of the Chalk Vessel Finds at Kh. Qumran
Authors: Adler Yonatan 
Published: January 2020

Abstract
Scholars have argued that 11QTa and CD view stone vessels as susceptible to impurity. Chalk vessel finds at Kh. Qumran have presented a challenge to this idea, and solutions to date have been unsatisfying. The recent publication of final reports on these finds invites us to reconsider both the archaeological and textual evidence relating to the ritual status of stone vessels at Qumran. The typological profile of the Kh. Qumran assemblage parallels that found at Jewish sites elsewhere. It will be argued that both 11QTa and CD viewed stone vessels as unsusceptible to most kinds of ritual impurity—apart from corpse impurity. The pentateuchal basis for this understanding will be elucidated, and it will be argued that the position of 11QTa and CD on the matter was common among contemporary Jews. The foregoing will allow an investigation into the origins of the chalk vessel industry in the late 1st century BCE.
Carotenoid supplementation affects the post-hibernation performance of southern corroboree frogs
Authors: McInerney Emma P. , Silla Aimee J. , Byrne Phillip G. 
Published: January 2020

Abstract
Many animals hibernate to survive winter conditions, however, arousal from hibernation generates reactive oxygen species (ROS) that can cause oxidative stress. Dietary antioxidants, like carotenoids, may reduce oxidative stress during arousal from hibernation, and assist with post-hibernation recovery and performance. We tested the effect of carotenoid supplementation on exercise performance (escape-response and activity) in southern corroboree frogs (Pseudophryne corroboree) following initial arousal from hibernation (24–48 h post-arousal) and post-recovery (six weeks post-hibernation). Carotenoids did not affect performance following initial arousal. However, carotenoids improved escape-response six weeks post-hibernation, with carotenoid-supplemented frogs hopping faster and further in their first hop than unsupplemented frogs. Carotenoids also affected post-recovery activity, with carotenoid-supplemented frogs being less mobile than unsupplemented frogs. Carotenoids may affect post-hibernation performance by reducing oxidative stress or by increasing diet quality. Our study provides novel evidence for an effect of carotenoids on performance post-hibernation and highlights the importance of nutrition to hibernating organisms.
Redesigning Today’s Driving Automation Toward Adaptive Backup Control With Context-Based and Invisible Interfaces
Authors: Cabrall Christopher D. D. , Stapel Jork C. J. , Happee Riender , de Winter Joost C. F. 
Published: January 2020

Objective We investigated a driver monitoring system (DMS) designed to adaptively back up distracted drivers with automated driving. Background Humans are likely inadequate for supervising today’s on-road driving automation. Conversely, backup concepts can use eye-tracker DMS to retain the human as the primary driver and use computerized control only if needed. A distraction DMS where perceived false alarms are minimized and the status of the backup is unannounced might reduce problems of distrust and overreliance, respectively. Experimental research is needed to assess the viability of such designs. Methods In a driving simulator, 91 participants either supervised driving automation ( auto-hand-on-wheel vs. auto-hands-off-wheel), drove with different forms of DMS-induced backup control ( eyes-only-backup vs. eyes-plus-context-backup; visible-backup vs. invisible-backup), or drove without any automation. All participants performed a visual N-back task throughout. Results Supervised driving automation increased visual distraction and hazard non-responses compared to backup and conventional driving. Auto-hand-on-wheel improved response generation compared to auto-hands-off-wheel. Across entire driving trials, the backup improved lateral performance compared to conventional driving. Without negatively impacting safety, the eyes-plus-context-backup DMS reduced unnecessary automated control compared to the eyes-only-backup DMS conditions. Eyes-only-backup produced low satisfaction ratings, whereas eyes-plus-context-backup satisfaction was on par with automated driving. There were no appreciable negative consequences attributable to the invisible-backup driving automation. Conclusions We have demonstrated preliminary feasibility of DMS designs that incorporate driving context information for distraction assessment and suppress their status indication. Application An appropriately designed DMS can enable benefits for automated driving as a backup.
Cyanoacrylate glue embolisation for varicose veins – A novel complication
Authors: Langridge Benjamin J , Onida Sarah , Weir Justin , Moore Hayley , Lane Tristan RA , Davies Alun H 
Published: January 2020

Background Non-thermal non-tumescent methods for varicose vein treatment have rapidly gained popularity in recent years due to clinical efficacy comparable to other endovenous methods, but with a superior safety and tolerability profile. Cyanoacrylate is an adhesive that rapidly polymerises during endovenous treatment to cause rapid occlusion of veins and initiate vein fibrosis. Method Cyanoacrylate glue treatment is known to cause complications such as phlebitis, cellulitis and deep vein thrombosis in rare instances. We present the first reported case of cyanoacrylate extravasation with chronic foreign body reaction in a patient nine months after initial treatment. Results We discuss the aetiology of this complication, its treatment, patient outcome and its significance to both clinicians and patients. Conclusion Cyanoacrylate glue embolisation can, in rare instances, lead to extravasation and chronic foreign body reaction, necessitating surgical intervention. The relative novelty of cyanoacrylate glue embolisation in the treatment of varicose veins requires clinicians to monitor for rare complications during its use in clinical practice. Patients should be aware of the rare risk of glue extravasation and foreign body reaction for fully informed consent prior to treatment.
Are Low-Income Consumers Willing to Pay for Fortification of a Commercially Produced Yogurt in Bangladesh
Authors: Agnew Jessica , Henson Spencer , Cao Ying 
Published: January 2020

Background: There is an active debate over the potential for market-based strategies to address micronutrient deficiencies in low- and middle-income countries. However, there are questions over the viability of market-based strategies, reflecting limited evidence on the value that low-income households attach to the nutritional attributes of processed foods. Objective: The objective of this article is to investigate the willingness to pay of primary food purchasers in low-income households in rural Bangladesh for Shokti+, a nutritionally fortified yogurt produced and distributed by Grameen Danone Foods Limited. Methods: A real choice experiment with economic incentives was conducted with 1000 rural food purchasers sampled from the distribution area of Shokti+ in rural Bangladesh. The choices of respondents revealed attribute nonattendance, favoring the fortification attribute over price. Results: Results from a random parameter logit model found that respondents were willing to pay an average of 18 BDT (US$0.22) for fortification and 6 BDT (US$0.073) for brand name. The market price for Shokti+ at the time of the study was 10 BDT (US$0.12). The results from a random effects model suggest the magnitude of willingness to pay for fortification was primarily driven by the nutritional awareness of respondents but offset by household food insecurity. Conclusions: The article concludes that, while there is a viable market for fortified yogurt in rural Bangladesh, efforts to promote this product as a strategy to address micronutrient deficiency are best targeted at low-income households with some capacity to pay for low priced commercially produced foods.
Clinical Epidemiology of Alcohol Use Disorders in Military Personnel versus the General Population in Canada: Épidémiologie clinique des troubles liés à la consommation d’alcool chez les militaires par opposition à la population générale du Canada
Authors: Taillieu Tamara L. , Afifi Tracie O. , Zamorski Mark A. , Turner Sarah , Cheung Kristene , Stein Murray B. , Sareen Jitender 
Published: January 2020

Objectives: Research suggests a high prevalence of problematic alcohol use among military personnel relative to civilians. Our primary objectives were to compare the prevalence, correlates, help-seeking behaviors, perceived need for care, and barriers to care for alcohol use disorders (AUDs) in the Canadian Armed Forces (CAF) and the Canadian general population (CGP). Methods: Data were from 2 nationally representative surveys collected by Statistics Canada: (1) the Canadian Community Health Survey on Mental Health collected in 2012 ( N = 25,113; response rate = 68.9%) and (2) the Canadian Forces Mental Health Survey collected in 2013 ( N = 8,161; response rate = 79.8%). Descriptive statistics and logistic regression were used to examine differences in outcomes of interest associated with AUDs in the CAF and CGP. Results: The prevalence of lifetime AUDs was significantly higher in the CAF (32.0%) than the CGP (20.3%; adjusted odds ratio [AOR] = 1.14, 95% confidence interval [CI, 1.02 to 1.27]) after adjustment for sociodemographic covariates. In contrast, the past-year prevalence of AUDs was significantly lower among CAF personnel (4.5%) than civilians (3.8%; AOR = 0.78, 95% CI [0.61 to 0.99]) after adjustment for sociodemographic covariates. Child abuse history and comorbid mental disorders were strongly associated with past-year AUDs in both populations. CAF personnel compared to the CGP were more likely to perceive a need for care (AOR = 4.15, 95% CI [2.56 to 6.72]) and engage in help-seeking behaviors (significant AORs ranged from 1.85 to 5.54). CAF personnel and civilians with past-year AUDs reported different barriers to care. Conclusions: Findings argue for the value of different approaches to address unmet need for AUD care in the CAF and CGP.
Ocular involvement in systemic lupus erythematosus patients: a paradigm shift based on the experience of a tertiary referral center
Authors: Dias-Santos A , Tavares Ferreira J , Pinheiro S , Cunha J P , Alves M , Papoila A L , Moraes-Fontes M Francisca , Proença R 
Published: January 2020

Objective To evaluate ocular involvement in a cohort of systemic lupus erythematosus (SLE) patients of a tertiary referral center and to compare the results with the existing literature. Methods Patients underwent a complete ophthalmological evaluation, including visual acuity, slit-lamp examination, fluorescein staining, Schirmer-I test, Goldmann applanation tonometry, fundoscopy, 10-2 automated threshold visual fields, fundus autofluorescence and spectral-domain optical coherence tomography to screen for hydroxychloroquine (HCQ) macular toxicity. Results A total of 161 patients (16 men and 145 women) were enrolled in this study. The mean age was 47.6 years and the mean disease duration was 11.5 years. Fifty patients (31.1%) had at least one ocular manifestation of SLE. The most frequent manifestation was dry eye syndrome (12.4%), immediately followed by cataracts (11.2%) and HCQ macular toxicity (11.2%). Among patients with HCQ maculopathy, two presented with an atypical spectral-domain optical coherence tomography pattern. Five patients (3.1%) presented with glaucoma, two patients (1.2%) presented with SLE retinopathy while only one presented with lupus choroidopathy (0.6%). Conclusions Compared with previous studies, we conclude there has been a significant reduction in disease-related ocular complications, particularly those associated with poor systemic disease control. On the other hand, drug and age-related complications are assuming a prominent role in the ophthalmic care of these patients.
An interpretative phenomenological analysis of dignity in people with multiple sclerosis
Authors: Žiaková Katarína , Čáp Juraj , Miertová Michaela , Gurková Elena , Kurucová Radka 
Published: January 2020

Background: Dignity is a fundamental concept in healthcare. The symptoms of multiple sclerosis have a negative effect on dignity. Understanding of lived experience of dignity in people with multiple sclerosis is crucial to support dignity in practice. Research aim: The aim was to explore the sense of dignity experienced by people with multiple sclerosis. Research design and participants: An interpretative phenomenological analysis design was adopted, using data collected through face-to-face interviews with 14 participants. Ethical considerations: The study was approved by the faculty Ethical Committee (No. EC 1828/2016). Findings: Four interconnected superordinate themes emerged from analysis: Loss of a fully-fledged life: Violating the dignity-of-self; To accept and fight: Promoting the dignity-of-self; Contempt and rudeness: Indignity-in-relation; and Those who know and see, help: Promoting dignity-in-relation. The loss of former fully-fledged life has a dramatic impact on integrity and impaired dignity-of-self. Accepting illness and changed identity impaired by multiple sclerosis was the step that the participants considered to be important for reacquiring the sense of dignity. The participants encountered misunderstandings, prejudices, embarrassment, insensitive remarks, labelling, unwillingness and impersonal treatment as indignities. Acceptance of their condition, needed support, the feeling of being part of a group, sensitivity and the sharing of problems had a positive effect on their dignity. Discussion: Continual changes in functional ability threaten an individual’s identity and were experienced as violations of dignity. Based on this, participant’s dignity-of-self was not a moral, but much more existential value. Acceptance of changed identity and fighting spirit were important for restoring their dignity-of-self. The misunderstandings, prejudices and unwillingness had a negative impact on their dignity-in-relation. On the other side, support from others in fighting promoted their dignity-in-relation. Conclusion: Dignity is manifested as a complex phenomenon of lived experience of people with multiple sclerosis and also an umbrella concept for providing good quality of person-centred care.
Gaming Exercise for Rights-Conversion-Type Urban Redevelopment Project in International Cooperation Context
Authors: Kaneda Toshiyuki , Cui Mingji , Sahab Sofia , Sadiq Ahmad Ramin 
Published: January 2020

Background. The rights conversion is an emerging approach on international cooperation that aims to solve the urban renewal problems in the 21st century. Previous research centred on the development of a rights-conversion-type urban redevelopment project game (URPG) for rights holders considering a project in Japan. Here, we focus on the application of URPG into Kabul City in Afghanistan, being presented with an opportunity for transfer by interuniversity collaboration. We introduce a gaming exercise herein as part of an action research to solve Kabul’s current urban renewal problems. Aim. Our paper is especially focused on the international transfer of the URPG. The content includes the background, process and formalisation of the rights conversion and reports on the outline of the two versions of URPG and a play content analysis of the Kabul version. It also mentions the implications of international differences in social systems highlighted from the episodes of the debriefing. Method. Our action research is evolved from the soft system approach by adding the gaming exercise, which is regarded as its main component. Results. The implications of the action research are summarised as follows: (1) URPG is a game that deals with the core mechanism of the rights conversion. Herein, we confirmed the basic performance of the Kabul version for undergraduate education in specialised courses. (2) Through a debriefing discussion, we revealed the cultural differences for rights notions on lands, which were subsequently taken into the legislative preparation of the rights conversion by the Afghanistan government. (3) Moreover, we revealed that URPG can deal with a project implementation problem in a given case, although the institutional design of the legislative project framework is a significant problem. Thus, a new gaming exercise based on these two-layered formulations is required.
Reliability Study of Diagnostic Tests for Functional Hallux Limitus
Authors: Sánchez-Gómez Rubén , Becerro-de-Bengoa-Vallejo Ricardo , Losa-Iglesias Marta Elena , Calvo-Lobo César , Navarro-Flores Emmanuel , Palomo-López Patricia , Romero-Morales Carlos , López-López Daniel 
Published: January 2020

Background: Functional hallux limitus (FHL) refers to dorsiflexion hallux mobility limitation when the first metatarsal head is under loading conditions but not in the unloaded state. The goal of the study was to evaluate 3 common manual tests (Buell, Dananberg, and Jack tests) for assessing first metatarsophalangeal joint (MPJ) mobility and determining the normal values needed to detect FHL, and clarify the signs and symptoms associated with this pathology. Methods: Forty-four subjects were included in this reliability study. Subjects were divided into healthy control (non-FHL) and FHL groups according to the Buell first MPJ limitation values in addition to signs and symptoms derived from the literature. In both groups, we measured the mobility in the Buell, Dananberg, and Jack tests using a goniometer; their intraclass correlation coefficients (ICCs), sensitivities, and specificity indexes were also calculated. Results: All techniques showed high reliability across measurement trials with ICCs ranging from 0.928 to 0.999. The optimal mobility grades for predicting FHL were 68.6 ± 3.7 degrees, 21 ± 5.9 degrees, and 25.5 ± 6.5 degrees (mean±SD) ( P < .05) for the Buell, Dananberg, and Jack tests, respectively. Conclusion: Normal and limited mobility values were established for assessing FHL using each technique. The sensitivity and specificity data were perfect for the Dananberg and Jack tests, thus identifying these tests as specific and valid tools for use in FHL diagnosis. Pinch callus was the sign most associated with FHL. Level of Evidence: Level II, comparative series.
Accuracy of the Hill–radial basis function method and the Barrett Universal II formula
Authors: Nemeth Gabor , Modis Laszlo 
Published: January 2020

Purpose: The aim was to assess the postoperative results of a biometric method using artificial intelligence (Hill–radial basis function 2.0), and data from a modern formula (Barrett Universal II) and the Sanders–Retzlaff–Kraft/Theoretical formula. Methods: Phacoemulsification and biconvex intraocular lens implantation were performed in 186 cataractous eyes. The diopters of intraocular lens were established with the Hill–radial basis function method, based on biometric data obtained using the Aladdin device. The required diopters of the intraocular lens were also calculated by the Barrett Universal II formula and with the Sanders–Retzlaff–Kraft/Theoretical formula. The differences between the manifest postoperative refractive errors and the planned refractive errors were calculated, as well as the percentage of eyes within ±0.5 D of the prediction error. The mean- and the median absolute refractive errors were also determined. Results: The mean age of the patients was 70.13 years (SD = 10.67 years), and the mean axial length was 23.47 mm (range = 20.72–28.78 mm). The percentage of eyes within a prediction error of ±0.5 D was 83.62% using the Hill–radial basis function method, 79.66% with the Barrett Universal II formula, and 74.01% in the case of the Sanders–Retzlaff–Kraft/Theoretical formula. The mean- and the median absolute refractive errors were not statistically different. Conclusion: Clinical success was the highest when using the biometric method, based on pattern recognition. The results obtained using Barrett Universal II came a close second. Both methods performed better compared to a traditionally used formula.