bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complex treatment of patients with chronic non-specific back pain and comorbid disorders: a prospective clinical study
Authors: Golovacheva A. A. , Golovacheva V. A. 
Published: December 2024

A complex approach including an educational program, ergonomics, kinesiotherapy and pharmacotherapy is effective in the treatment of patients with chronic non-specific back pain (CNBP). The efficacy of complex treatment with personalized kinesiotherapy in patients with CNBP and comorbid disorders has not yet been sufficiently investigated.Objective: to evaluate the efficacy of a complex treatment including special kinesiotherapy, standard pharmacological and non-pharmacological methods in patients with CNBP and comorbid disorders.Material and methods. The study included 60 patients (12 men and 48 women, mean age 38.3±8.7 years) with CNBS and comorbid disorders (neck pain, insomnia, tension type headaches, anxiety and/or depressive symptoms). Patients were randomized into two groups: group 1 received complex treatment, including special kinesiotherapy, standard therapy (educational program, standard kinesiotherapy, non-steroidal anti-inflammatory drugs, muscle relaxers, antidepressants in some patients), group 2 – standard therapy. The clinical and psychological parameters of all patients were analyzed at baseline, and after 1, 3 and 6 months of treatment.Results. After 1 month of treatment, the clinical effect (CE) in terms of CNBS (reduction of back pain (BP) intensity according to the numerical rating scale and Oswestry questionnaire by 30% or more) was achieved in 80% of patients in group 1, which is statistically significantly (p<0.05) higher than in group 2 (46.7% of patients). By month 3 of observation, the number of patients achieving CE increased to 86.7% in group 1 and decreased to 36.6% in group 2. After 6 months, all patients in group 1 maintained the achieved CE, while in group 2 only 30% of patients maintained CE. In group 1, a complete regression of BP was observed in more than one third of patients at month 3 and 6 of observation (33.3 and 36.6%, respectively). In group 2, no regression of BP was observed in any case. In group 1, in contrast to group 2, a statistically significant (p<0.05) decrease in scores on the Beck Pain Catastrophizing Scale, the Kinesiophobia Scale, Beck Anxiety and Depression Scale, the Insomnia Severity Index, Headache Impact Index and Neck Pain Disability Index was observed. The decrease continued until the 6th month of observation.Conclusion. A complex treatment comprising special kinesiotherapy, standard non-drug and drug therapy leads to a rapid (after 1 month) positive effect in patients with CNBP and comorbid disorders that lasts over a long period of time (6 months).
The impact of emotional burnout in psychiatrists on the outcomes of the care they provide
Authors: Bykov K. V. , Medvedev V. E. 
Published: December 2024

The quality of medical care largely depends on the mental well-being of medical staff. One of the most common manifestations of work-related distress is emotional burnout syndrome (EBS). The emotional burnout in psychiatrists is favored by many specific work factors.Objective: to investigate the relationship between EBS in psychiatrists and the outcomes of the care they provide.Material and methods. Eighty-two psychiatrists working in psychiatric clinics in Moscow took part in the study. They completed the Maslach Burnout Inventory on their own. Two hundred medical records of hospitalized patients suffering from paranoid schizophrenia were selected. A total of 100 patient records of psychiatrists with emotional burnout and 100 patient records of psychiatrists without emotional burnout were analyzed.Results. Emotional burnout was found in 25.6% of psychiatrists. In cases of emotional burnout, psychiatrists were more likely to prescribe anticholinergic corrective medication for extrapyramidal symptoms (61% versus 44%; p=0.023). The presence of emotional burnout in psychiatrists correlated with a longer duration of hospitalization of patients they cared for (31.2 versus 29 days; p=0.004) and with more frequent polypharmacy (67% versus 51%; p=0.031).Conclusion. Emotional burnout in psychiatrists has a negative impact on the quality of care they provide.
Evaluation of the content of microbial metabolites in cerebrospinal fluid of individuals with radiologically isolated syndrome
Authors: Omarova M. A. , Zhilenkova O. G. , Boyko A. N. 
Published: December 2024

Over the past decade, a large amount of data has been obtained on the role of the gut microbiota in the development of diseases of the nervous system. In particular, the literature contains data on the composition of the gut microbiota in multiple sclerosis (MS). However, the body's microbiome is not limited to the gut microbiota. Of particular interest are the body fluids that are in direct contact with the nervous tissue, such as cerebrospinal fluid (CSF). In our previous studies, we have already analyzed the CSF in different variants of MS course and found the markers of different microbes, which confirms the hypothesis of the association of MS with polymicrobial infection. No less interesting is the transitional state – radiologically isolated syndrome (RIS), in which less attention was paid to analyzing the microbiome.Objective: to evaluate the content of microbial metabolites in the CSF of individuals with RIS and in the control group.Material and methods. The content of microbial markers in the CSF was determined using gas chromatography-mass spectrometry in 10 individuals with RIS and in 10 individuals in the control group.Results. We found a statistically significant increase in the content of microbiota markers in the CSF of individuals with RIS, namely a statistically significant increase in the content of markers of Epstein–Barr virus, Propionibacterium acnes bacteria, Pseudomonas, Moraxella and Acinetobacter.Conclusion. The results of this study are consistent with the hypothesis of a possible association between MS and polymicrobial infection, particularly infection with Epstein–Barr virus.
ZAG promotes colorectal cancer cell proliferation and epithelial–mesenchymal transition by promoting lipid synthesis
Authors: Xu Maotao , Jin Xingzheng , Shen Zhouli 
Published: December 2024

Abstract
Colorectal cancer (CRC) is a common malignant tumor characterized by a high degree of invasiveness, and since zinc-α2 glycoprotein (ZAG) has been implicated in the progression of several malignancies, this study was designed to investigate the role of ZAG in CRC. Its expression was assessed using the GEPIA database, and short hairpin RNA (shRNA) interference was conducted to create ZAG knockdown in CRC cell lines. We also conducted lipid synthesis, cell proliferation, apoptosis, and epithelial–mesenchymal transition (EMT) experiments to elucidate the effects of ZAG expression on CRC, as well as explored the potential underlying mechanistic pathways. Our findings reveal that ZAG is overexpressed in CRC. In vitro, ZAG knockdown resulted in the suppression of lipid production, cell division, and EMT while concurrently promoting apoptosis. The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway was found to mediate the effects of ZAG on CRC cells. In conclusion, the downregulation of ZAG can inhibit CRC cell survival, EMT, and lipid production via the PI3K/AKT/mTOR signaling pathway.
The benthic marine algae of the Maldives: historical insights into their diversity and distribution
Authors: Nicolai Rossella , Zuccarello Giuseppe C. , Karsten Ulf , Louis Yohan D. , Cerri Federico , Senna Giulia , Mohamed Shazla , Galli Paolo 
Published: December 2024

Abstract
In tropical ecosystems worldwide, benthic marine algae are important primary producers and habitat providers for many juvenile fish and invertebrate species. Calcified species are known to provide structural support to their respective communities, thus enhancing the overall system’s productivity. In the Republic of the Maldives, algae are an important yet currently poorly studied biological resource. We reviewed the literature around algal diversity and distribution across Maldivian atolls and compiled an extensive and updated taxonomic list. The list contains 353 species, of which 31 are Cyanobacteria, 26 Phaeophyceae, 109 Chlorophyta, and 187 Rhodophyta. Algal collections have been reported from 12 out of 20 atolls, and these mostly occurred during 20th century expeditions. The taxonomic status of 110 species has changed since first reported. While several species have been documented from the country, identifications have thus far almost solely relied on morphological assessments. Many of the reported algal groups require molecular confirmation. This suggests that benthic algal diversity from the Maldives is likely an underestimate. Since anthropogenic activities can significantly alter algal community dynamics, a baseline understanding of algal diversity is necessary to determine how such shifts affect the ecosystem as a whole, thus underpinning future management and conservation efforts.
Equality Rights and Unequal Property Rights in Multi-owned Buildings
Authors: Ahlinder Elisabeth 
Published: December 2024

Abstract

288This paper address how the collective decision-making process in multi-owned property associations can affect and limit disabled residents right to live an independent life and discusses alternative legal solutions to this problem. It examines whether, and if so how, placing more emphasis on property law and its fundamental function in society can provide an equally strong protection of disabled residents accessibility rights as does the application of discrimination law.
This research builds on and contributes to legal doctrinal and theoretical research on negative external societal effects of the democratic governance model of multi-owned properties in general, and, in particular, of decisions and restrictions regarding permission to install ramps or keep assistance dogs. The main argument is that if property law is used as a tool to steer and adjust societal normative expectations from a right to control to a duty to respect, this normative change would reduce the need for using external legislative solutions, such as applying discrimination laws, to achieve important societal objectives. Moreover, this approach could also reduce the need for future legislation addressing other societal challenges, such as the right to install electric vehicle chargers in common parking areas. These right-to-charge issues, which are currently being tackled through new EU-directives, reflect similar tensions between individual needs and collective governance. A property law-based solution that fosters fairness and flexibility in decision-making could pre-emptively address these types of issues, making it easier for associations to accommodate both current and future societal demands without the need for additional layers of regulation.
Queer Theology on Social Media: A Reflection on Queer Pastoral Influencers on Instagram
Authors: Müller Sabrina , Knapp Aline , Merian Katharina , Todjeras Patrick 
Published: December 2024

Abstract
The field of Queer Theology can be enhanced by qualitative research on queer lived experiences. The present article addresses this through exploratory observations. The authors examine how two queer pastors (@amen_aber_sexy and @tovja_behuetet) express queer issues on Instagram, interact with Christian tradition, and engage in Queer Theology. Within the scope of this article, Instagram emerges as a productive space for lived Queer Theology based on Felix Stalder’s principle of referentiality.
Apresentação
Authors: Borges Cecilia , Souza Neto Samuel de , Sarti Flavia , Benites Larissa 
Published: December 2024

Desde a década de 90, a formação docente vem passando por transformações profundas em relação ao lugar, às modalidades e à duração dos estágios ao longo de formação inicial (Cochran-Smith & Zeichner, 2005; Darling-Hammond, Chung & Frelow; Gervais & Correa Molina, 2008; Gervais & Desrosiers, 2001, 2005; Tardif, Lessard, & Gauthier, 1998). Estas transformações, que estão na base do discurso sobre a profissionalização, assumem formatos específicos em função das características de cada país e de cada contexto universitário. Todavia, o ponto para o qual elas convergem é o de considerar a prática profissional como um lócus de produção e também de formação nos saberes. Lembremos que o movimento pela profissionalização docente exige considerar o ensino como uma atividade profissional de alto nível, alicerçada sobre uma sólida base de conhecimentos que é ela mesma integrada às práticas profissionais que a nutrem e enriquecem graças à contribuição de docentes experientes e de pesquisadores que colaboram entre si (Tardif, Lessard e Gauthier, 1998). Desse ponto de vista, de um lado, os docentes são tomados como profissionais reflexivos, capazes de deliberar sobre suas práticas, de objetivá-las, de inová-las, de torná-las mais eficazes e acessíveis aos pares; de outro, a prática passa a ser considerada como um espaço original e relativamente autônomo de aprendizagem e de formação dos futuros docentes. Concretamente, em alguns países, isso deu origem a adoção de um modelo de alternância na base dos dispositivos de formação inicial. Neste busca-se alternar teoria e prática, num vai-e-vem entre o meio universitário e o meio escolar, a fim de favorecer vínculos mais estreitos entre a experiência de campo e a teoria oriunda da pesquisa e entre os docentes e os universitários implicados na formação.
Diálogos pertinentes na formação inicial e continuada de professores e gestores escolares. A concepção do Programa de Residência Pedagógica na UNIFESP
Authors: Giglio Celia Maria Benedicto , Lugli Rosario Silvana Genta 
Published: December 2024

Este artigo trata da experiência desenvolvida na Universidade Federal de São Paulo (UNIFESP) a partir da concepção do Programa de Residência Pedagógica (PRP) no Curso de Pedagogia. A base teórica dessa proposição inicial teve inspiração na Pedagogia da Alternância, produzindo uma metodologia para a formação prática em estreito vínculo com as escolas públicas de educação básica do Município de Guarulhos (São Paulo, Brasil). Essa metodologia confronta questões que envolvem as instituições formadoras – universidade e escolas - em diversos aspectos. Finaliza discutindo o caráter sistêmico presente na dimensão da formação inicial prática de professores, e a imprescindível gestão estratégica dessa formação, acenando para uma desejável vinculação entre a formação inicial e continuada de professores e gestores.
Patient Centered, Clinical, Radiographic, and Biochemical comparative evaluation of Transgingival and Conventional Flapped Implant surgical technique: A randomized controlled trial
Authors: Verma Dr Umesh Pratap , Parikh Dr Harshil Vinaykumar , Ul Haque Dr Aehad , Lal Dr Nand , Rastogi Dr Pavitra , Pathak Dr Anjani , Rao Dr Jitendra 
Published: December 2024

ABSTRACT
A multifaceted study compared transgingival (flapless) implant placement with conventional flapped placement, which employed clinical, radiographic, biochemical, and patient-centered parameters. The study was approved by the institutional ethics committee and was conducted according to the ethical standards in the 1964 Declaration of Helsinki and its amendments. Seventy-five implants were placed, 37 by flapless method (group 1) and 38 by flapped method (group 2). The Group 1 subjects underwent flapless implant placement, while Group 2 underwent flapped implant placement. The modified plaque index was significantly higher in group 2 at 6 weeks (Mann Whitney test, z = -3.08, p = .002). Modified sulcus bleeding index was also significantly higher in group 2, up to the 12-week follow-up (Mann Whitney test, z = -4.63, p &lt; .001). Crestal bone loss revealed no significant intergroup difference. Under biochemical evaluation, matrix metalloproteinase-8 (MMP-8) was significantly higher in flapped implants up to the 6-week follow-up. The patient-reported questionnaire-based acceptability assessment showed that the flapless technique is better regarding the perceived duration of the surgery and post-operative comfort.
FDFK2D: Efficient Two-Dimensional Teleseismic Wavefield Modeling for Receiver Function Analysis Using a Hybrid Method
Authors: Liu Youshan , Wu Chenglong , Xu Tao , Zhao Liang , Teng Jiwen 
Published: December 2024

Abstract
We develop a Fortran package with high programming optimization and parallel computing for simulating high-frequency (&gt;1 Hz) teleseismic wavefields using a hybrid numerical method that couples the finite-difference (FD) and frequency–wavenumber (FK) methods. This method can simulate the interactions of incoming teleseismic wavefields with local heterogeneities but reduce computational region to a much smaller localized domain, which can significantly reduce the computing cost of the high-frequency teleseismic wavefields. The local heterogeneities are allowed to vary arbitrarily in a localized heterogeneous domain. In this package, the geographical locations of earthquakes are permitted, which can consider the real azimuthal effect of the source. Numerical benchmark tests first demonstrate the effectiveness of the developed method for P- and S-wave receiver functions (RFs). The consistent travel times of synthetic and theoretical RFs phases demonstrate its high accuracy. Application on a dense array generally obtains consistent RFs profiles with observed ones and successfully reproduces the observed common-converted-point (CCP) stacking image, which further verifies the effectiveness of the presented method. In addition, statistics of the time-consuming of typical models illustrate the high efficiency of this package, which needs very little computing resources even to be feasible on a laptop.
Tecnologias sociais da memória
Authors: Souza Claudia Moraes de 
Published: December 2024

O artigo tem como tema central a construção da memória social e reflexões sobre a resistência política de operários, sindicalistas e seus familiares, vitimados pela ditadura empresarial militar brasileira. O contexto é o das resistências políticas e ações sindicais relativas ao arrocho salarial promovido pelo governo militar desde o Golpe de 1964 e a Greve de trabalhadores da Companhia Brasileira de Material Ferroviário (COBRASMA) realizada em 1968, na cidade de Osasco. Nossos objetivos buscaram gerar conhecimento público e acesso às informações relativas à presença da referida empresa em episódios que envolvem o controle e a repressão à organização sindical, a criminalização da Greve Operária de 1968 e a desproporcional repressão aos trabalhadores. Buscamos explicitar fatos da colaboração entre a empresa e aparelhos da repressão, como o DOPS/SP, denunciando as práticas de vigilância e perseguição política de operários grevistas e sindicalistas no mercado de trabalho e no cotidiano da empresa. A História Oral acionada como método de investigação foi utilizada como forma de estabelecer a memória social acerca dos acontecimentos que envolvem a violação de direitos do trabalho e direitos humanos. Combinando a História Oral (HO) e Tecnologias Sociais da Memória (TSM) produzimos um conjunto de entrevistas gravadas em audiovisual que se materializam em um “banco de histórias” disponibilizados no site Memórias Resistentes.
Ecosystem style of thinking in economic analysis: principle of unity of the continuous and the discrete
Authors: Karpinskaya V. A. 
Published: December 2024

Objective: to substantiate the unity of the discrete and the continuous in the socio-economic ecosystems theory development. Methods: system economic theory; the theory of the system structure influence on the changing homogeneity of the intraecosystem space-time; the systemic-integrational theory of an enterprise; the principle of complementarity. Results: the article substantiates the expediency of introducing the “ecosystem style of thinking” concept into scientific circulation. It is shown that the basic principle of the ecosystem style of thinking is the principle of complementarity, expressed as the unity of the continuous and the discrete. This principle is due to the inherent characteristic of the ecosystem – a combination of continuity and discreteness of its intra-ecosystem space-time (in particular, a combination of homogeneity and diversity of relationships between ecosystem participants). In order to form methods for determining the qualitative relationship between the ecosystem homogeneity and heterogeneity, the author proposes a typology of relationships between ecosystem participants, formed on the basis of the systemic-integrational theory of an enterprise. The paper substantiates the importance of a rational correlation of the homogeneity and diversity of the ecosystem space-time for the ecosystem functioning and for identifying the imbalances in the ecosystem spatiotemporal development. Scientific novelty: It was found that the main characteristic of the ecosystem style of thinking is the principle of unity of the continuous and the discrete in economic analysis. The author concludes that the ecosystem style of thinking is based on the post-non-classical style of thinking as interpreted by V. S. Stepin. The article proposes a typology of the economic analysis principles and substantiates the typology of relationships in the ecosystem based on the system integration theory of an enterprise. The author draws attention to the need for a rational balance between homogeneity and diversity in the ecosystem relationships for its functioning. Practical significance: the research expands the arsenal of objective methods for studying economic phenomena and processes by applying the ecosystem approach principles.
Comparative analysis of meso-level strategies: region, industry, corporation
Authors: Kobylko A. A. , Rybachuk M. A. 
Published: December 2024

Objective: to identify the features of strategies of various entities at mesoeconomical level: territorial systems (regions), industries and large corporations (ecosystems) based on a comparative analysis of their structure, key elements and attributes. Methods: a structural approach to strategic documents at the macro-, meso- and microlevels, comparative analysis and synthesis, review of theoretical research and practice of strategy formation and implementation. Results: the article defines the features of strategy formation at the regional, industry and corporate levels. The author states that the key difference between regional and sectoral strategies is a long planning horizon, while corporate strategies are more often subject to adjustment. The article shows that the strategies of mesoeconomical level entities have a number ofsystemic problems related to their formation and implementation. It was found that due to the variability and turbulence of environmental conditions, the entities at meso-level are forced to constantly adjust their strategies, while corporate strategies, unlike regional and sectoral ones, are not limited by the top-level strategy. The author reveals the shortcomings of interaction and coordination (institutional vacuum) of strategies of macro-, meso- and micro-level entities in terms of coherence and coordination of actions in long-term planning. Scientific novelty: it consists in applying a structural approach to the analysis of strategies of meso-level entities, comparing them and identifying common features and differences in approaches to their formation and implementation. Practical significance: it consists in the developing applied methods for the formation and implementation of strategies and improving the effectiveness of strategic planning at the mesoeconomical level.