bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical solutions of fractional parabolic equations with generalized Mittag–Leffler kernels
Authors: Alomari Abedel‐Karrem , Abdeljawad Thabet , Baleanu Dumitru , Saad Khaled M. , Al‐Mdallal Qasem M. 
Published: December 2020

AbstractIn this article, we investigate the generalized fractional operator Caputo type (ABC) with kernels of Mittag–Lefller in three parameters and its fractional integrals with arbitrary order for solving the time fractional parabolic nonlinear equation. The generalized definition generates infinitely many problems for a fixed fractional derivative α. We utilize this operator with homotopy analysis method for constructing the new scheme for generating successive approximations. This procedure is used successfully on two examples for finding the solutions. The effectiveness and accuracy are verified by clarifying the convergence region in the ℏ‐curves as well as by calculating the residual error and the results were accurate. Based on the experiment, we verify the existence of the solution for the new parameters. Depending on these results, this treatment can be used to find approximate solutions to many fractional differential equations.
Global and local structure‐based influential nodes identification in wheel‐type networks
Authors: Berberler Murat Erşen 
Published: December 2020

AbstractNetwork theory has been widely used to describe complex systems in the real world. Identifying the influential nodes in a network is one of the most important topic in the research of network theory. Identification of influential nodes in a network is a significant and challenging task since influential nodes act as a hub for information transmission in a command and control network, however it is necessary if the invulnerability of the network is to be increased. The global and local structure (GLS) is a reasonable and efficacious method to quantify the influence of nodes in a network model. The influence of a node depends not only on its own influence but also on the ability of other nodes in the network to contribute to its influence. This method was also proved to be accurate and efficient in influential node analysis within a network. In this paper, influential node analysis is conducted in wheels and related networks based on GLS.
The embodiment of craft production in Bronze Age Portugal: Exceptional dental wear grooves in an individual from Monte do Vale do Ouro 2 (Ferreira do Alentejo, Portugal)
Authors: Willman John Charles , Valera António Carlos , Silva Ana Maria 
Published: December 2020

AbstractTwo human lateral mandibular incisors exhibiting exceptional dental wear in the form of lingual surface grooves along the cementoenamel junction were recovered from the superficial levels of a pit grave attributed to the Bronze Age at the archaeological site of Monte do Vale do Ouro 2 (Ferreira do Alentejo, Beja, Portugal). Although a number of analyses of dental wear features acknowledge the relatively common use of the dentition for nondietary purposes (using the ‘teeth as tools’) during the Early/Middle Bronze Age (2200–1200 BC) of southwest Iberia, the form of dental wear documented at Monte do Vale do Ouro 2 is not only a novel finding in this region but also has seldom been described in any bioarchaeological context. The present study provides a macroscopic and low‐magnification description of the atypical dental wear for this individual. Results indicate that the incisors are likely antimeres. In addition to the deep lingual grooves, asymmetrical wear removed a substantial portion of the laterolingual crown volume of each tooth. Occlusal and lingual surface wear accumulated slowly enough for tertiary dentin to form. An occlusal groove is also present on the right I2. A review of ethnohistoric and bioarchaeological literature suggests that some form of craft production involving the manipulation of cordage or fibre with the mouth and teeth can account for the unique wear patterns from Monte do Vale do Ouro 2. The hand‐spinning of flax requires wetting which can be accomplished by passing flax fibres through the mouth in a mediolateral direction while using a hand spindle. Similar habitual behaviours were probably practiced by the Bronze Age individual from Monte do Vale do Ouro 2. The wear grooves represent the embodiment of aspects of craft production and maintenance activities that occurred during this individual's lifecourse.
Optimal Avapritinib Treatment Strategies for Patients with Metastatic or Unresectable Gastrointestinal Stromal Tumors
Authors: Joseph Cissimol P. , Abaricia Sarah N. , Angelis Michelle A. , Polson Kathleen , Jones Robin L. , Kang Yoon-Koo , Riedel Richard F. , Schöffski Patrick , Serrano César , Trent Jonathan , Tetzlaff Eric D. , Si Tuan Dong , Zhou Teresa , Doyle Ashley , Bauer Sebastian , Roche Maria , Havnaer Tracy 
Published: December 2020

Abstract

Background
Avapritinib, a novel inhibitor of KIT/PDGFRA, is approved in the U.S. for the treatment of adults with PDGFRA exon 18-mutant unresectable or metastatic gastrointestinal stromal tumors (U/M GISTs). We assessed the safety of avapritinib and provide evidence-based guidance on management of avapritinib-associated adverse events (AEs), including cognitive effects and intracranial bleeding.

Materials and Methods
We performed a post hoc analysis of data from a two-part, single-arm dose escalation/expansion phase I study (NAVIGATOR; NCT02508532) in patients with U/M GISTs treated with oral avapritinib 30–600 mg once daily. The primary endpoints were safety and tolerability; the impact of dose modification (interruption and/or reduction) on progression-free survival (PFS) was a secondary endpoint. Efficacy analyses were limited to patients who started avapritinib at 300 mg (approved dose).

Results
Of 250 patients enrolled in the study, 74.0% presented with KIT mutation and 24.8% presented with PDGFRA exon 18-mutation; 66.8% started avapritinib at 300 mg. The most common treatment-related AEs (any grade) were nausea (59.2%), fatigue (50.0%), periorbital edema (42.0%), anemia (39.2%), diarrhea (36.0%), vomiting (36.0%), and increased lacrimation (30.8%). No treatment-related deaths occurred. Among 167 patients starting on 300 mg avapritinib, all-cause cognitive effects rate (grade 1–2) was 37.0% in all patients and 52.0% in patients ≥65 years. Cognitive effects improved to a lower grade more quickly with dose modification (1.3–3.1 weeks) than without (4.9–7.6 weeks). Median PFS was 11.4 months with dose modification and 7.2 months without.

Conclusion
Tolerability-guided dose modification of avapritinib is an effective strategy for managing AEs in patients with GISTs.

Implications for Practice
Early recognition of adverse events and tailored dose modification appear to be effective approaches for managing treatment-related adverse events and maintaining patients on avapritinib. Dose reduction does not appear to result in reduced efficacy. Patients' cognitive function should be assessed at baseline and monitored carefully throughout treatment with avapritinib for the onset of cognitive adverse events. Dose interruption is recommended at the first sign of any cognitive effect, including grade 1 events.
Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Any Benefit When Ki-67 Is ≥10%?
Authors: Merola Elettra , Alonso Gordoa Teresa , Zhang Panpan , Al-Toubah Taymeyah , Pellè Eleonora , Kolasińska-Ćwikła Agnieszka , Zandee Wouter , Laskaratos Faidon , Mestier Louis , Lamarca Angela , Hernando Jorge , Cwikla Jaroslaw , Strosberg Jonathan , Herder Wouter , Caplin Martin , Cives Mauro , Leeuwaarde Rachel 
Published: December 2020

Abstract

Background
Long-acting somatostatin analogs (SSAs) are the primary first-line treatment of well-differentiated advanced gastroenteropancreatic neuroendocrine tumors (NETs), but data about their efficacy in pancreatic NETs (panNETs) with Ki-67 ≥10% are still limited.

Materials and Methods
To assess the clinical outcomes of advanced, nonfunctioning, well-differentiated panNETs with Ki-67 ≥10% receiving first-line long-acting SSAs in a real-world setting, we carried out a retrospective, multicenter study including patients treated between 2014–2018 across 10 centers of the NET CONNECT Network. The primary endpoints were time to next treatment (TNT) and progression-free survival (PFS), whereas overall survival (OS) and treatment safety were secondary endpoints.

Results
A total of 73 patients were included (68 grade [G]2, 5 G3), with liver metastases in 61 cases (84%). After a median follow-up of 36.4 months (range, 6–173), the median TNT and PFS were 14.2 months (95% confidence interval [CI], 11.6–16.2) and 11.9 months (95% CI, 8.6–14.1) respectively. No statistically significant difference was observed according to the somatostatin analog used (octreotide vs. lanreotide), whereas increased tumor grade (hazard ratio [HR], 4.4; 95% CI, 1.2–16.6; p = .04) and hepatic tumor load (HR, 2; 95% CI, 1–4; p = .03) were independently associated with shortened PFS. The median OS recorded was 86 months (95% CI, 56.8–86 months), with poor outcomes observed when the hepatic tumor burden was &gt;25% (HR, 3.4; 95% CI, 1.2–10; p = .01). Treatment-related adverse events were reported in 14 patients, most frequently diarrhea.

Conclusion
SSAs exert antiproliferative activity in panNETs with Ki-67 ≥10%, particularly in G2 tumors, as well as when hepatic tumor load is ≤25%.

Implications for Practice
The results of the study call into question the antiproliferative activity of somatostatin analogs (SSAs) in pancreatic neuroendocrine tumors with Ki-67 ≥10%. Patients with grade 2 tumors and with hepatic tumor load ≤25% appear to derive higher benefit from SSAs. Prospective studies are needed to validate these results to optimize tailored therapeutic strategies for this specific patient population.
Clinical prognostic factors in pediatric adrenocortical tumors: A meta‐analysis
Authors: Zambaiti Elisa , Duci Miriam , De Corti Federica , Gamba Piergiorgio , Dall'Igna Patrizia , Ghidini Filippo , Virgone Calogero 
Published: December 2020

AbstractPediatric adrenocortical tumors (ACT) are rare and sometimes aggressive malignancies, but there is no consensus on the outcome predictors in children. A systematic search of MEDLINE, SCOPUS, Web of Science, and the Cochrane Library for studies from 1994 to 2020 about pediatric ACT was performed. In 42 studies, 1006 patients, aged 0‐18 years, were included. The meta‐analyses resulted in the following predictors of better outcome: age <4 years (P < .00001), nonsecreting tumors (P = .004), complete surgical resection (P < .00001), tumor volume (P < .0001), tumor weight (P < .00001), tumor maximum diameter (P = .0009), and Stage I disease (P < .00001). Moreover, patients affected by Cushing syndrome showed a worse outcome (P < .0001). International prospective studies should be implemented to standardize clinical prognostic factors evaluation, together with pathological scores, in the stratification of pediatric ACT.
Engineering printable composites of poly (ε‐polycaprolactone) / β‐tricalcium phosphate for biomedical applications
Authors: Beatrice Cesar Augusto Gonçalves , Shimomura Kawany Munique Boriolo , Backes Eduardo Henrique , Harb Samarah Vargas , Costa Lidiane Cristina , Passador Fabio Roberto , Pessan Luiz Antonio 
Published: December 2020

AbstractThe incorporation of bioactive β‐tricalcium phosphate (TCP) into poly (ε‐polycaprolactone) (PCL) originates a composite biomaterial with required properties for a variety of biomedical application. We manufactured bioactive composites of PCL/TCP by melt compounding and assessed their rheological, structural, and thermal behavior, envisioning the use of the composites as filaments for additive manufacturing via fused filament fabrication (FFF). Biocomposites of PCL with 5 wt% and 10 wt% of TCP presented similar thermal stability, crystallinity, molecular weight, and rheological behavior of neat PCL, while the addition of 25 wt% TCP leads to the formation of TCP agglomerates and increased viscosity. These results show that low concentrations of TCP in the PCL matrix make it more suitable for FFF since no change in the printing process is required. PCL/TCP filaments were fabricated by a twin‐screw extruder and used to print scaffolds using FFF. The possibility to design scaffolds with specific size, geometry, and porosity enables the application of diverse types of tissue engineering. Herein, we demonstrated the feasibility of the fabrication of 3D printed PCL/TCP scaffolds for bone regeneration with improved mechanical properties and controlled geometry.
Enhancement of the thermal stability of PVC filled with multiwalled carbon nanotubes using new antimicrobic itaconimido aryl 1,3,4‐oxadiazoles
Authors: Mohamed Nadia A. , Al‐Harby Nouf F. 
Published: December 2020

AbstractA series of PVC films stabilized with novel antimicrobial itaconimido aryl 1,3,4‐oxadiazoles (D1'‐D4'), at absence or presence of various concentrations of multiwalled carbon nanotubes (MWCNTs), was prepared by a conventional solution casting method. D1'‐D4' was prepared via thermal cyclization processes by loss of water for their congruous predecessors itaconimido aryl hydrazides. Elemental analysis and various spectroscopy measurements were used to prove their structures. D1'‐D4' have great antimicrobial activities and some of them showed similar or sometimes higher impact than the reference antibiotic. From TG measurements in nitrogen, they have high thermal stabilities and their decomposition temperatures were above 275–310°C in accordance with substituent groups NH2 and/or OH incorporated into their structures. They have higher thermal stabilizing efficiencies for PVC in comparison with some industrial thermal stabilizers. Inclusion of 0.1–0.5 wt% MWCNTs into PVC films, that were stabilized with D4', enhanced the composites thermal stability. XRD, SEM as well as TEM were used for ascertaining of incorporation and well dispersion of MWCNTs into PVC matrices. Additionally, the efficacy of stabilization has been proven via a decreased rate of color alteration, mechanical properties change and chains cleavage for PVC. The high antimicrobial and thermal characteristics of these stabilizers afford them a great possibility to secure antimicrobial thermally stable PVC composites. Also, improvement of thermal and mechanical properties of PVC stabilized by D4' after its incorporation with MWCNTs afford a great possibility to its application in different fields where their thermal resistance and high tensile strength resistance play a very important role.
Composite helical spring with skin‐core structure: Structural design and compression property evaluation
Authors: Jiang Qian , Qiao Ye , Zhao Feng , Pan Zhongxiang , Wu Xianyan , Wu Liwei , Fu Hongjun 
Published: December 2020

AbstractThe helical spring is an essential mechanical component of automobile and machinery and has been widely used in industrial application. The weight reduction is the requirement of current material design and also the research trend for material development. In this study, a novel composite helical spring with “skin‐core” structure was designed and fabricated with an integrated formation process based on the vacuum‐assisted resin infusion technology. Based on the different function of skin and core, the skin structure was weft knitting tube made of aramid and ultra‐high molecular weight polyethylene fiber, and the core structure was unidirectional carbon fiber. By selecting material for knitting tube and adjusting the volume content of carbon fiber core, the static and fatigue compression properties of composite helical spring were investigated. It has been found that the spring torsion and bending performance can be improved by wrapping the core with the knitting tube as the spring wire. Moreover, the finite element method was applied to further analyze the stress evolution of the “skin‐core” composite helical spring during compression and fatigue. The results of compression test and simulation show that the spring stiffness can be effectively improved by using knitting tube and increasing the content of carbon fiber. The stress of the spring cross section is concentrated in the internal radial region of 180°, and the distribution of the corresponding cross sections is relatively uniform. The “skin‐core” structure with aramid knitting tube as the outer skin and carbon fiber as the spring core significantly improves the load‐carrying capacity and stability of the composite spring. The proposed lightweight helical composite could provide a replacement strategy of existing metal or unidirectional filament reinforced springs used in the engineering applications.
Structural characterization and dielectric parameters of polyindole/WO3 nanocomposites
Authors: Erdönmez Seda , Karabul Yaşar , Kılıç Mehmet , Güven Özdemir Zeynep , Esmer Kadir 
Published: December 2020

AbstractIn the present study, polyindole/tungsten trioxide (PIn/WO3) nanocomposites have been prepared and characterized in the context of their structural properties as well as frequency‐dependent (ac) electrical features for the first time. While PIn polymer has been synthesized by chemical oxidative polymerization, WO3 nanorods have been obtained by using the hydrothermal method. Several studies, that is, transmission electron microscopy, Fourier transform infrared, energy dispersive X‐ray, X‐ray diffraction analysis, scanning electron microscopy, dielectric properties on these PIn/WO3 nanocomposites have been carried out. These investigations showed the average particle size of WO3 between 15.36 and 44.71 nm. The pure PIn and WO3 were compatible with the surface morphology of the PIn and WO3 reported in the scientific literature. The dielectric analyses have been carried out in the context of both the real and imaginary components of complex permittivity and electrical modulus. The ε′ values of all PIn/WO3 composites have been observed lower than that of pure Pln and ε′ decreased with the increasing amount of WO3 in the PIn matrix for the low‐frequency range. Electric modulus analysis showed that the increase in M′ value with frequency implies a tendency to reach a value which can be interpreted as short‐range mobile charge carriers perform the electrical conductivity.
Effect of secondary filler properties and geometry on the electrical, dielectric, and electromagnetic interference shielding properties of carbon nanotubes/polyvinylidene fluoride nanocomposites
Authors: Shayesteh Zeraati Ali , Mende Anjaneyalu Abilash , Pawar Shital Patangrao , Abouelmagd Ahmed , Sundararaj Uttandaraman 
Published: December 2020

AbstractHybrid polymer nanocomposites based on polyvinylidene fluoride (PVDF) as the matrix, carbon nanotubes (CNTs) as the primary conductive filler, and metal nanoparticles as secondary fillers were fabricated by melt mixing. Secondary nanofillers with different geometry and properties (nickel nanowire (NiNW), silver nanowire (AgNW), nickel nanoparticle (NiNP), and silver nanoparticle (AgNP) were selected to investigate the effect of geometry and properties of secondary filler on the hybrid polymer nanocomposites' properties. Electrical conductivity, electromagnetic interference (EMI) shielding effectiveness, and complex microwave properties of the fabricated hybrid nanocomposites were studied in X‐band frequency (8.2–12.4 GHz). The hybrid nanocomposites containing CNT/AgNW demonstrated superior conductivity and EMI shielding compared to individual fillers such as CNT, AgNW, NiNW, AgNP, NiNP, or hybrid system such as CNT/NiNW. The novelty of the present study lies in the unique synergy arising from the combination of nanofillers with similar geometry and high electrical conductivity, which resulted EMI shielding effectiveness as high as 27 dB for a shield with only 1.1 mm thickness. The EMI shielding mechanisms, including negative permittivity were studied and explained in details in the manuscript.
Study on water droplet initiated discharges and charge trap characteristics of laser textured silicone rubber nanocomposites
Authors: Vinod Pabbati , Amizhtan Somasundaram Karthikeyan , Ganesh Parvathy , Kornhuber Stefan , Srinivasan Balaji , Sarathi Ramanujam 
Published: December 2020

AbstractSilicone rubber micro‐nanocomposites were fabricated and laser texturing was performed on their surface to investigate super hydrophobic properties. Irrespective of type of texture (square, hexagon or diamond), the contact angle is almost the same but a marginal increase in contact angle is observed with increase in wt% of nano fillers in silicone rubber. Water droplet initiated corona inception voltage (CIV) is measured by fluorescence technique and the CIV tends to increase with texturing and is high under—DC followed with +DC and AC voltages. Fast Fourier Transform (FFT) analysis of the fluorescence signal due to corona discharge indicates that the energy content of the fluorescent signal lies in the range DC to 20 MHz. Surface temperature of the sample after water droplet initiated discharge is found to be high under DC rather than under AC voltages. Textured surface has a relatively lower temperature decay rate under AC and DC voltages profiles, compared to nontextured surface. The formation of shallow charge traps is predominant with the textured specimens. In general, the diamond and hexagonal micro textured surface specimen exhibit better performance in terms of water droplet initiated CIV, hydrophobicity, and surface potential decay characteristics.
Cross‐cultural adaptation of Life Satisfaction Checklist‐11 among persons with stroke in China: A reliability and validity study
Authors: Wang Rongrong , Hu Xiaolei , Zhang Tong , Fugl‐Meyer Kerstin Sjögren , Langhammer Birgitta 
Published: December 2020

AbstractObjectiveThe aim of the present study was to develop a cross‐cultural adaptation and to evaluate the validity and reliability of a Chinese version of the LiSat‐11 test.MethodsLiSat‐11 was translated into Chinese according to standardized procedures. A cross‐sectional descriptive study was conducted to examine its reliability and validity, in accordance to COnsensus‐based Standards for the election of health Measurements Instruments guidelines, among persons with stroke approximately 3 years after their discharge from rehabilitation. Participants completed the LiSat‐11, 36‐Item Short‐Form Health Survey (SF‐36), National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Barthel Index (BI) and Hospital Anxiety and Depression Scale (HADS). To examine the test–retest reliability, thirty of these participants completed LiSat‐11 again after 2 weeks.ResultsIn total, 60 persons with stroke were recruited. The Chinese version of LiSat‐11 demonstrated good internal consistency with Cronbach's alphas at 0.82. Ceiling effects were found in five of the eleven items of LiSat‐11, and there was a floor effect in one item. LiSat‐11 had moderate to high correlations with SF‐36 with Spearman's correlation coefficient (rho) ranging from 0.44 to 0.73 (p < 0.01) in a concurrent validity test, and high correlations were also found between LiSat‐11 and HADS‐A/D in a convergent validity test with rho = −0.63/−0.67 (p < 0.01). Low correlations with NIHSS, BI and mRS were found in a divergent validity test, rho = −0.25, 0.17 and −0.26, respectively.ConclusionThe current study verified that the translated Chinese version of the Life Satisfaction Checklist‐11 is a reliable and valid tool for measuring the life satisfaction of persons with chronic stroke.