bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study
Authors: Pastor-Barriuso Roberto , Pérez-Gómez Beatriz , Hernán Miguel A , Pérez-Olmeda Mayte , Yotti Raquel , Oteo-Iglesias Jesús , Sanmartín Jose L , León-Gómez Inmaculada , Fernández-García Aurora , Fernández-Navarro Pablo , Cruz Israel , Martín Mariano , Delgado-Sanz Concepción , Fernández de Larrea Nerea , León Paniagua Jose , Muñoz-Montalvo Juan F , Blanco Faustino , Larrauri Amparo , Pollán Marina 
Published: November 2020

Abstract

Objective
To estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all causes.

Design
Nationwide seroepidemiological study.

Setting
First wave of covid-19 pandemic in Spain.

Participants

Community dwelling individuals of all ages.

Main outcome measures
The main outcome measure was overall, and age and sex specific, infection fatality risk for SARS-CoV-2 (the number of covid-19 deaths and excess deaths divided by the estimated number of SARS-CoV-2 infections) in the community dwelling Spanish population. Deaths with laboratory confirmed covid-19 were obtained from the National Epidemiological Surveillance Network (RENAVE) and excess all cause deaths from the Monitoring Mortality System (MoMo), up to 15 July 2020. SARS-CoV-2 infections in Spain were derived from the estimated seroprevalence by a chemiluminescent microparticle immunoassay for IgG antibodies in 61 098 participants in the ENE-COVID nationwide seroepidemiological survey between 27 April and 22 June 2020.

Results
The overall infection fatality risk was 0.8% (19 228 of 2.3 million infected individuals, 95% confidence interval 0.8% to 0.9%) for confirmed covid-19 deaths and 1.1% (24 778 of 2.3 million infected individuals, 1.0% to 1.2%) for excess deaths. The infection fatality risk was 1.1% (95% confidence interval 1.0% to 1.2%) to 1.4% (1.3% to 1.5%) in men and 0.6% (0.5% to 0.6%) to 0.8% (0.7% to 0.8%) in women. The infection fatality risk increased sharply after age 50, ranging from 11.6% (8.1% to 16.5%) to 16.4% (11.4% to 23.2%) in men aged 80 or more and from 4.6% (3.4% to 6.3%) to 6.5% (4.7% to 8.8%) in women aged 80 or more.

Conclusion
The increase in SARS-CoV-2 infection fatality risk after age 50 appeared to be more noticeable in men than in women. Based on the results of this study, fatality from covid-19 was greater than that reported for other common respiratory diseases, such as seasonal influenza.
Community engagement approaches for Indigenous health research: recommendations based on an integrative review
Authors: Lin Chu Yang , Loyola-Sanchez Adalberto , Boyling Elaine , Barnabe Cheryl 
Published: November 2020

ObjectiveCommunity engagement practices in Indigenous health research are promoted as a means of decolonising research, but there is no comprehensive synthesis of approaches in the literature. Our aim was to assemble and qualitatively synthesise a comprehensive list of actionable recommendations to enhance community engagement practices with Indigenous peoples in Canada, the USA, Australia and New Zealand.DesignIntegrative review of the literature in medical (Medline, Cumulative Index to Nursing and Allied Health Literature and Embase) and Google and WHO databases (search cut-off date 21 July 2020).Article selectionStudies that contained details regarding Indigenous community engagement frameworks, principles or practices in the field of health were included, with exclusion of non-English publications. Two reviewers independently screened the articles in duplicate and reviewed full-text articles.AnalysisRecommendations for community engagement approaches were extracted and thematically synthesised through content analysis.ResultsA total of 63 studies were included in the review, with 1345 individual recommendations extracted. These were synthesised into a list of 37 recommendations for community engagement approaches in Indigenous health research, categorised by stage of research. In addition, activities applicable to all phases of research were identified: partnership and trust building and active reflection.ConclusionsWe provide a comprehensive list of recommendations for Indigenous community engagement approaches in health research. A limitation of this review is that it may not address all aspects applicable to specific Indigenous community settings and contexts. We encourage anyone who does research with Indigenous communities to reflect on their practices, encouraging changes in research processes that are strengths based.
Serum 25-hydroxyvitamin D levels in relation to lipids and clinical outcomes in pregnant women with gestational diabetes mellitus: an observational cohort study
Authors: Chen Wenqing , Li Yuan , Gao Bo , Li Jie , Zheng Mingming , Chen Xiaotian 
Published: November 2020

ObjectiveThe aim of the present study was to investigate whether 25-hydroxyvitamin D (25(OH)D) status at 24–28 weeks is associated with blood lipids and pregnancy outcomes in patients with gestational diabetes mellitus (GDM).DesignWe performed an observational cohort study.SettingThe study was conducted in China.ParticipantsA total of 261 pregnant women diagnosed with GDM at 24–28 weeks of gestation in our hospital were included between June 2015 and December 2017. According to the levels of 25(OH)D, the women were divided into the G1 (<20 ng/mL) and G2 (≥20 ng/mL) groups. The levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), TG/HDL-c and TC/HDL-c ratios were obtained from medical records. Pregnancy outcomes included gestational weeks of birth and delivery mode. Newborn information included birth weight and body length. Differences between groups were tested with adjusted multiple linear regression.ResultsThe serum levels of 25(OH)D (14.1±3.4 ng/mL vs 28.5±6.5 ng/mL, p<0.001), TC (5.3±0.9 vs 5.6±0.8, p=0.006), HDL-c (1.8±0.4 vs 1.9±0.4, p=0.046) and LDL-c (2.5±0.6 vs 2.7±0.7, p=0.015) in the G2 group were significantly higher than those in G1 group, while TG/HDL-c ratios (1.43±0.7 vs 1.26±0.7, p=0.035) were significantly higher in the G1 group. Moreover, we failed to find a significant difference in pregnancy outcomes of mothers and newborns among the two groups (p>0.05). In models adjusting for maternal age, parity, height, blood pressure, socioeconomic status, educational attainment, pre-pregnancy body mass index, season and gestational age, maternal 25(OH)D was associated with TG/HDL-c ratios (B=−0.016; 95% CI= −0.025 to –0.006).ConclusionWe found that there was no relationship between vitamin D and pregnancy/neonatal outcomes in our study. Maternal 25(OH)D at 24–28 weeks was inversely associated with TG/HDL-c ratios.
Assessment of patient and provider attitudes towards therapeutic drug monitoring to improve medication adherence in low-income patients with hypertension: a qualitative study
Authors: Schesing Kevin B , Chia Ricardo , Elwood Bryan , Halm Ethan A , Lee Simon J Craddock , Lodhi Hamza , Wu Bryan , Sharma Shishir , Smith Scott A , Jarrett Robin B , Das Sandeep R , Vongpatanasin Wanpen 
Published: November 2020

ObjectivesPrevious studies have implicated therapeutic drug monitoring (TDM), by measuring serum or urine drug levels, as a highly reliable technique for detecting medication non-adherence but the attitudes of patients and physicians toward TDM have not been evaluated previously. Accordingly, we solicited input from patients with uncontrolled hypertension and their physicians about their views on TDM.DesignProspective analysis of responses to a set of questions during semistructured interviews.SettingOutpatient clinics in an integrated health system which provides care for a low-income, uninsured population.ParticipantsPatients with uncontrolled hypertension with either systolic blood pressure of at least 130 mm Hg or diastolic blood pressure of at least 80 mm Hg despite antihypertensive drugs and providers in the general cardiology and internal medicine clinics.Primary and secondary outcome measuresAttitudes towards TDM and the potential impact on physician–patient relationship.ResultsWe interviewed 11 patients and 10 providers and discussed the findings with 13 community advisory panel (CAP) members. Of the patients interviewed, 91% (10 of 11) and all 10 providers thought TDM was a good idea and should be used regularly to better understand the reasons for poorly controlled hypertension. However, 63% (7 of 11) of patients and 20% of providers expressed reservations that TDM could negatively impact the physician–patient relationship. Despite some concerns, the majority of patients, providers and CAP members believed that if test results are communicated without blaming patients, the potential benefits of TDM in identifying suboptimal adherence and eliciting barriers to adherence outweighed the risks.ConclusionThe idea of TDM is well accepted by patients and their providers. TDM information if delivered in a non-judgmental manner, to encourage an honest conversation between patients and physicians, has the potential to reduce patient–physician communication obstacles and to identify barriers to adherence which, when overcome, can improve health outcomes.
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy
Authors: Hernandez-Voth Ana , Sayas Catalan Javier , Corral Blanco Marta , Castaño Mendez Alba , Martin Miguel Angel , De Fuenmayor Fernandez de la Hoz Carlos , Villena Garrido Victoria , Dominguez-Gonzalez Cristina 
Published: November 2020

BackgroundRecessive mutations in the thymidine kinase 2 (TK2)gene cause a rare mitochondrial myopathy, frequently with severe respiratory involvement. Deoxynucleoside therapy is currently under investigation.Research questionWhat is the impact of nucleosides in respiratory function in patients with TK2-deficient myopathy?Study design and methodsRetrospective observational study of patients treated with deoxycytidine and deoxythymidine. Evaluations were performed every 3 to 4 months after treatment during approximately 30 months. Forced vital capacity (FVC), maximuminspiratory and expiratory pressures (MIP/MEP), sniff nasal inspiratory pressure (SNIP), cough peak flow (CPF), arterial blood gas and nocturnal pulse oximeter (SpO2) were collected.ResultsWe studied six patients, five of which were women, with a median age at onset of symptoms was 35.8 (range 5 to 60) years old. Patients presented a restrictive ventilatory pattern (median FVC of 50 (26 to 71)%) and severe neuromuscular respiratory weakness (MIP 38 (12 to 47)% and SNIP 14 (8 to 19) cmH2O). Four patients required ventilatory support before starting the treatment. FVC improved by 6%, proportion of sleep time with SpO2 <90% diminished from 14% to 0%, CPF increased by 23%, MEP increased by 73%, production and management of bronchial secretions improved and respiratory infections diminished.InterpretationEarly detection of respiratory involvement requires an active search, even in asymptomatic patients. The nucleosides therapy may improve respiratory function, and stabilise the loss of respiratory capacity.
A blood biomarker and clinical correlation cohort study protocol to diagnose sports-related concussion and monitor recovery in elite rugby
Authors: Kearns Jamie , Ross Aisling M , Walsh Darragh R , Cahalane Rachel M , Hinchion Rita , Ryan Maria C , Conway Elaine , Comyns Tom M , Kenny Ian C , O’Connor Eibhlís M , McGourty Kieran D , Mulvihill John Joseph Eugene 
Published: November 2020

IntroductionIn professional rugby, sports-related concussion (SRC) remains the most frequent time loss injury. Therefore, accurately diagnosing SRC and monitoring player recovery, through a multi-modal assessment process, is critical to SRC management. In this protocol study, we aim to assess SRC over multiple time points post-injury to determine the value of multi-modal assessments to monitor player recovery. This is of significance to minimise premature return-to-play and, ultimately, to reduce the long-term effects associated with SRC. The study will also establish the logistics of implementing such a study in a professional setting to monitor a player’s SRC recovery.Methods and analysisAll players from the participating professional rugby club within the Irish Rugby Football Union are invited to participate in the current study. Player assessment includes head injury assessment (HIA), neuropsychometric assessment (ImPACT), targeted biomarker analysis and untargeted biomarker analysis. Baseline HIA, ImPACT, and blood draws are performed prior to the start of playing season. During the baseline tests, player’s complete consent forms and an SRC history questionnaire. Subsequently, any participant that enters the HIA process over the playing season due to a suspected SRC will be clinically assessed (HIA and ImPACT) and their blood will be drawn within 3 days of injury, 6 days post-injury, and 13 days post-injury.Ethics and disseminationEthical approval was attained from the Science and Engineering Research Ethics Committee, University of Limerick (Approval Code: 2018_06_11_S&E). On completion of the study, further manuscripts will be published to present the results of the tests and their ability to measure player recovery from SRC.Trial registration numberNCT04485494.
Risk for cardiovascular events following ‘microsize’ versus usual myocardial infarctions
Authors: Almarzooq Zaid I , Colantonio Lisandro D , Okin Peter M , Richman Joshua S , Brown Todd M , Levitan Emily B , Bryan Joanna , Safford Monika M 
Published: November 2020

BackgroundMicrosize myocardial infarction (MI) is a recently described phenomenon that meets rigorous criteria for MI with very low peak troponin elevations. We aim to compare the risk for cardiovascular events and mortality following microsize versus usual MIs.Methods and resultsProspective cohort analysis of REasons for Geographic And Racial Differences in Stroke (REGARDS) study participants without a history of coronary heart disease (CHD) who had an incident MI between 2003 and 2015. Incident MIs were classified as microsize MI (peak troponin <0.5 ng/mL) or usual MI (peak troponin ≥0.5 ng/mL). Participants were followed for a composite of cardiovascular events that included recurrent MI, coronary revascularisation, fatal CHD and heart failure, and all-cause mortality. Overall, 1024 participants with an incident MI were included in the analysis (328 with microsize MI and 696 with usual MI). Participants with microsize MI were more likely to be older and black. The multivariable-adjusted adjustment HR for cardiovascular events among participants with microsize versus usual MI after a median follow-up of 1.7 years was 1.11 (95% CI 0.86 to 1.44). The multivariable-adjusted HR for all-cause mortality after 28 days from incident MI among participants with microsize versus usual MI after a median follow-up of 3.6 years was 1.09 (95% CI 0.81 to 1.45).ConclusionMicrosize MIs have a prognostic value for future cardiovascular events and mortality comparable to usual MIs. These findings should encourage clinicians to initiate secondary prevention strategies in patients with microsize MI until this emerging clinical entity is better understood.
Carboniferous macrofloral biostratigraphy: an overview
Authors: Opluštil Stanislav , Cleal Christopher J. , Wang Jun , Wan Mingli 
Published: November 2020

Abstract
In the Carboniferous, terrestrial vegetation became widespread, diverse and abundant. The resulting fossil record has proved to be an effective biostratigraphic tool for intra- and interbasinal correlations. Besides palaeogeographical configurations, Carboniferous plant biostratigraphy is affected by a transition from greenhouse conditions during most of the Mississippian to an icehouse climate in the Pennsylvanian. The greenhouse Mississippian climate resulted in weak provincialism, with a cosmopolitan flora ranging from the tropics to middle latitudes. The global cooling around the Mississippian–Pennsylvanian boundary enhanced development of a latitudinal climatic zonation and related floral provincialism. These changes are expressed in the recognition of distinct realms or kingdoms, where the tropical Amerosinian Realm (or Euramerican and Cathaysian realms) is surrounded by the Angaran and Gondwanan realms occupying middle to high latitudes of the northern and southern hemispheres, respectively. Floristic endemism in the Pennsylvanian precludes development of a global macrofloral biostratigraphy. Instead, each realm or area has its own biostratigraphic scheme. Poorer and less diverse floras of the Gondwanan and Angaran realms resulted in the establishment of relatively low-resolution macrofloral biostratigraphic schemes. Higher-resolution macrofloral zonations exist only in the tropical Amerosinian Realm due to diverse and abundant floras dominated by free-sporing and early seed plants occupying extensive wetlands.
A practical ply-based appearance model of woven fabrics
Authors: Montazeri Zahra , Gammelmark Søren B. , Zhao Shuang , Jensen Henrik Wann 
Published: November 2020

Simulating the appearance of woven fabrics is challenging due to the complex interplay of lighting between the constituent yarns and fibers. Conventional surface-based models lack the fidelity and details for producing realistic close-up renderings. Micro-appearance models, on the other hand, can produce highly detailed renderings by depicting fabrics fiber-by-fiber, but become expensive when handling large pieces of clothing. Further, neither surface-based nor micro-appearance model has not been shown in practice to match measurements of complex anisotropic reflection and transmission simultaneously.
In this paper, we introduce a practical appearance model for woven fabrics. We model the structure of a fabric at the ply level and simulate the local appearance of fibers making up each ply. Our model accounts for both reflection and transmission of light and is capable of matching physical measurements better than prior methods including fiber based techniques. Compared to existing micro-appearance models, our model is light-weight and scales to large pieces of clothing.
A new species of the genus Eucalliaxiopsis Sakai, 2011 from the South China Sea (Decapoda, Axiidea, Eucalliacidae)
Authors: Liu Wenliang , Poore Gary C. B. 
Published: November 2020

Abstract
Eucalliaxiopsis liui sp. nov. is described from a specimen taken from the South China Sea. The new species differs from other species of Eucalliaxiopsis in the combination of a telson with a transverse posterior margin, without a transverse row of spiniform setae, and a hook on the upper margin of the carpus of the cheliped. Eucalliaxiopsis liui is unique in having a biramous female pleopod 2, its endopod slender, with finger-like appendix interna, and a slender segmented exopod.
Who Built Old St Peter’s? The Evidence of the Inscriptions and Mosaics
Authors: Logan Alastair 
Published: November 2020

Abstract
Old St Peter’s in Rome, according to the sixth-century Liber Pontificalis, was founded by Constantine (306–337), a claim accepted by most scholars who appeal to a variety of evidence. This paper will challenge this, focusing on the inscriptional and mosaic evidence and developing the arguments of Glen Bowersock and Alastair Logan that it was not constructed by Constantine at all but by one of his sons, in all likelihood Constans (337–350). It will argue that he began it in the late 340s as a five-aisled cemeterial basilica which Constantius II (337–361) completed in the late 350s, adding the apse mosaic. The paper will argue for the fundamental significance of two anonymous inscriptions and claim that the key evidence cited has not properly included one of them and in fact reflects the growing influence of legends about Constantine and Silvester.
“Learn to Restrain Your Mouth”: Alchemical Rumours and their Historiographical Afterlives
Authors: Prinke Rafał T. , Zuber Mike A. 
Published: November 2020

Abstract
From around 1700 onwards, a number of sensationalist claims regarding adepts of
the sixteenth and early seventeenth centuries began to appear in alchemical
literature. They eventually made their way into standard works of historiography
and continue to be repeated as factual. Yet the source for these rumours, a poem
attributed to Martinus de Delle, supposedly a chamberlain of Emperor Rudolf II,
has largely escaped scrutiny. The only surviving manuscript version currently
known is here edited and translated in full for the first time. In the
introductory essay, we call into question the existence of De Delle. Through
scrutiny of the portrayals of alchemists within the poem, we propose that the
author may have been an assayer in Prague. We then draw attention to the roles
and effects of rumours within both the history and historiography of alchemy and
argue for the importance of taking alchemical gossip seriously.
Remaking the Catholic Church in Santo Domingo
Authors: Keane-Dawes Antony Wayne 
Published: November 2020

Abstract
In 1824, the Haitian government passed a series of laws that secularized the Catholic Church’s lands in Santo Domingo and placed this religious institution under state control. Using correspondences, pamphlets, and petitions, this article argues that Haitian reforms of the Church in Santo Domingo created a new power dynamic that incorporated local communities with these secular and religious institutions. In doing so, this literature brings together two literatures that rarely speak to one another: the impact of the Haitian Unification on the Church in Santo Domingo and Haitian diplomatic negotiations over sovereignty in the Atlantic world. This article will discuss how different relationships between Church and state in Santo Domingo and Haiti resulted in conflict after Haiti’s annexation in 1822. Next, it will focus on the clerics’ responses to Haitian rule that includes the consequences of the 1824 secularization law. Finally, it will examine the impact of Haitian reforms on local communities particularly their relationships with their priests.
Perceived Congruency in Audiovisual Stimuli Consisting of Gabor Patches and AM and FM Tones
Authors: Postnova Natalia , Nakajima Yoshitaka , Ueda Kazuo , Remijn Gerard B. 
Published: November 2020

Abstract
Experiments that focus on how humans perceive temporal, spatial or synaesthetic congruency in audiovisual sensory information have often employed stimuli consisting of a Gabor patch and an amplitude (AM) or frequency (FM)-modulated sound. Introducing similarity between the static and dynamic features of the Gabor patch and the (carrier) frequency or modulation frequency of the sound is often assumed to be effective enough to induce congruency. However, comparative empirical data on perceived congruency of various stimulus parameters are not readily available, and in particular with respect to sound modulation, it is still not clear which type (AM or FM) induces perceived congruency best in tandem with various patch parameters. In two experiments, we examined Gabor patches of various spatial frequencies with flickering (2, 3 and 4 flickers/s) or drifting (0.5, 1.0 and 1.5 degrees/s) gratings in combinations with AM or FM tones of 2-, 3- and 4-Hz modulation and 500-, 1000- and 2000-Hz carrier frequencies. Perceived congruency ratings were obtained by asking participants to rate stimulus (in)congruency from 1 (incongruent) to 7 (congruent). The data showed that varying the spatial frequency of the Gabor patch and the carrier frequency of the modulated tone had comparatively little impact on perceived congruency. Similar to previous findings, similarity between the temporal frequency of the Gabor patch and the modulated tone effectively promoted perceived congruency. Furthermore, direct comparisons convincingly showed that AM tones in combination with flickering Gabor patches received significantly higher audiovisual congruency ratings compared to FM tones.