bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation and psychometric evaluation of the Dutch Person-centred care of Older People with cognitive impairment in Acute Care (POPAC)
Authors: Keuning-Plantinga Annette , Finnema Evelyn , Krijnen Wim , Edvardsson David , Roodbol Petrie 
Published: February 2020

Abstract
Background People with dementia are regularly hospitalized. Person-centered care is the preferred model for caring for people with dementia. To improve the quality of care for people with dementia in an acute care setting, knowledge of the level of person-centeredness of the care is relevant. The POPAC is a tool to determine the level of Person-centred care. Translation enables international comparisons of data and outcomes of Person-centred care. This study aimed to translate and cross-nationally validate the Dutch Person-centred care of Older People with cognitive impairment in Acute Care scale and to evaluate its psychometric properties. Methods After translation, a total of 159 nurses recruited from six hospitals and via social media completed the POPAC. A confirmatory factor analysis was performed to test the factor-structure, and a Cronbach’s alpha scale was utilized to establish the reliability of the scale. Results A confirmatory factor analysis showed that the fit by the Confirmatory Fit Index was a nearly acceptable model fit. The Root Mean Square Error of Approximation and the Standardized Root Mean Square Residual suggested an acceptable model fit. The findings of the authors confirm a three-dimensional structure suggested by previous research. The loadings of the items indicate that these are strong associations with each of the factors. Besides, the factor correlations also indicate that these are strongly associated. These findings indicate that the factors are strongly associated with a general POPAC factor. This study confirms that, statistically, Item 5 could be deleted to improve the reliability of the instrument. Instead of deleting this item, the authors suggest considering rephrasing it into a positive item. Conclusions The Dutch version of the POPAC is sufficiently valid and reliable and can be utilized for assessing person-centered care in acute care hospitals. The study enables nurses to interpret and compare levels of Person-centred care in wards and hospital levels between regions and countries. The results form an important basis for improving the quality of care and nurse-sensitive outcomes such as prevention of complications and length of hospital stay.
The efficacy of a novel zinc-containing desensitizer CAREDYNE Shield on dentin hypersensitivity: study protocol for a pilot randomized controlled trial
Authors: Matsuura Takashi , Mae Megumi , Ohira Masayuki , Yamashita Yasunori , Nakazono Ayako , Sugimoto Kouji , Yanagiguchi Kajiro , Yamada Shizuka 
Published: February 2020

Abstract
Background: Dentin hypersensitivity (DH) is a condition characterized by short and sharp pain which will arise in response to tactile, chemical, thermal, evaporative or osmotic stimuli. The painful symptoms cause discomfort to the patients and decrease their quality of life. Recently, a novel zinc-containing desensitizer CAREDYNE Shield is developed. It is a new type of desensitizer which acts as a desensitizer by inducing chemical occlusion of dentinal tubules, and releases zinc ion for root caries prevention. However, the clinical effectiveness of CAREDYNE Shield on DH is still unclear. Therefore, the aim of this study is to evaluate the effectiveness of CAREDYNE Shield on DH by comparing with that of another desensitizer Nanoseal commonly used in Japan.Methods/Design: This study protocol is a two-arm parallel pilot randomized controlled trial. Forty DH patients will be randomly allocated into 2 groups. Participants in the intervention group will be treated with CAREDYNE Shield; participants in the control group will be treated with Nanoseal. Primary outcome is the reduction of pain intensity in response to air stimuli measured with 5-points verbal response scale from baseline to 4 weeks after the intervention and Fisher's exact test will be used for analysis.Discussion: CAREDYNE Shield can be casually applied to subgingival areas and proximal surfaces because it reacts with only tooth substance. Moreover, zinc is reported to reduce the demineralization of enamel and dentin and inhibit biofilm formation, plaque growth and dentin collagen degradation. Therefore, CAREDYNE Shield may be expected to become a novel useful desensitizer which act not only as a desensitizer but also as a root caries inhibitor.
Defining the perceived self-care ability in stroke patients living at home in Middle East region : protocol for a systematic Literature review
Authors: Dalvandi Asghar , Jafari-golestan Nasrin , Hosseini Mohammadali , Fallahi-Khoshknab Masoud , Ebadi Abbas , Rahgozar Mahdi , Sidani Souraya , Keshtkar Abbas 
Published: February 2020

Abstract
BackgroundStroke has several adverse outcomes and is accompanied by physical, cognitive, perceptual, mental, emotional, and sensory disorders. These disorders influence patients’ perceived self-care ability. There is no single agreed-upon definition for the perceived self-care ability in stroke patients living at home, and such a definition may differ based on different cultures and settings, for example in the Middle East compared to advanced countries. The main objective of this systematic Literature review is to summarize the literature on the topic and propose a definition that might help stroke research in the future. MethodsThe databases PubMed, Scopus, CINAHL, PsycINFO, PEDro, Web of Science, ProQuest, ScienceDirect, Index Medicus, EMRO, Google Scholar, Magiran, SID, IranDoc, and stroke-related literature will be queried individually to retrieve relevant literature on perceived self-care ability in stroke patients using subject headings and appropriate MeSH terms. The inclusion and exclusion criteria will be developed and refined by the research team. Two independent reviewers will participate in each search stage, including abstract/title and full-text screening, study selection, data collection, and quality assessment steps. We will restrict our search to articles published in the English languages in biomedical journals between 1970 and 2018. The result will be presented in tabular form, and meta-synthesis will be performed.DiscussionThe results of this systematic literature review can present a more accurate definition of perceived self-care ability in stroke patients living at home in Middle East countries, for researchers who aim to conduct new studies on the subject.
Safety and Immunogenicity of the Quadrivalent Human Papillomavirus Vaccine in Patients with Juvenile Dermatomyositis: A Real-World Multicentre Study
Authors: Pinto Natalia Balera Ferreira , Grein Ingrid Herta Rotstein , Lobo Aline , Groot Noortje , Sztajnbok Flavio , Aikawa Nadia Emi , Marques Luciana Brandão Paim , Appenzeller Simone , Islabão Aline Garcia , de Oliveira Sheila Knupp Feitosa , Bica Blanca Elena Rios Gomes , Fraga Aline Coelho Moreira da , Robazzi Teresa Cristina Martins Vicente , Barbosa Cassia Maria Passarelli Lupoli , Pasmans Hella , Schepp Rutger , Klis Fiona van der , de Roock Sytze , Wulffraat Nico , Pileggi Gecilmara Salviato 
Published: February 2020

Abstract
Background: Concerns about the safety and efficacy of vaccinations in patients with pediatric rheumatic diseases, such as juvenile dermatomyositis, have led to contradictions and low vaccination coverage in this group, who are at a higher risk of infections, including by human papillomavirus (HPV). Although HPV vaccine should be recommended for all juvenile dermatomyositis patients, there is a lack of data to support the safety of this vaccine. The aim of this study was to assess the safety and immunogenicity of the quadrivalent HPV vaccination in juvenile dermatomyositis patients.Methods: Juvenile dermatomyositis patients aged from 9-20 years and healthy controls were enrolled to receive a 3-dose schedule of quadrivalent HPV vaccination from March/2014 until March/2016. Study visits were performed before the first dose, one month after the second and third doses and one year after the first dose. Participants completed a diary of possible adverse events following each dose, and disease activity was measured. At each visit, serum samples was collected for testing antibody concentrations. Participants recruitment was conducted in ten Brazilian centers. From 48 eligible patients, 42 completed the 3 doses schedule of the vaccine (5 patients had received doses previously). The McNemar test and the Kappa concordance coefficient were applied to compare the disease activity scores used for juvenile dermatomyositis patients between quadrivalent HPV vaccine doses and before the vaccination. The software used was SAS 9.4.Results: No severe adverse events were related to the vaccination. The disease activity scores were usually low, and remained stable, or even improved during the follow-up. After three vaccine doses the juvenile dermatomyositis group presented seropositivity of 100% for HPV16 and 97% for HPV18, similarly to the control group who presented 100% for both. One year after the first dose the seropositivity for the patients group was 94% for both HPV types.Conclusions: The HPV vaccination in juvenile dermatomyositis patients is safe and immunogenic. Since the seropositivity against HPV16 and HPV18 was very high after the 3-dose schedule, this regimen should be recommended for juvenile dermatomyositis patients.
Employers' perception of breastfeeding practice of employed mothers: a qualitative study
Authors: Wolde Firmaye Bogale , Ali Jemal Haidar , Mengistu Yalemwork Getnet 
Published: February 2020

Abstract
Background : The universal benefits of breastfeeding and human milk are demonstrated by different researches but despite the advantages only 37% of children are exclusively breastfed worldwide. Women employment is one way of ensuring women's empowerment but it is also one of the commonly mentioned factors contributing for the low prevalence of breastfeeding. Hence, there needs to be a conducive work environment that accommodates maternal needs not to fall back from empowerment and to improve breastfeeding practice. There are not many studies that focus on work environment in relation with employers’ experience and their perception of breastfeeding of employed mothers. Therefore this study aims to explore employers’ experience and perception of employed mothers’ breastfeeding experience in different working environments in Addis Ababa, Ethiopia.
Methods : A descriptive Phenomenology strategy was employed in this study and purposive sampling technique was used to recruit study participants. Data was collected from 10 employers from private, governmental and non-governmental institutions through an in-depth interview. Thematic data analysis was performed where collected data was organized, coded and categorized into themes to give meaningful contributions to answering the research questions.
Results : Understanding breastfeeding, current maternity leave, perception of breastfeeding supporting conditions and mother-friendly work environment were the themes generated after analysis. Almost all employers in this study recognized the importance of breastfeeding despite the different work environments they worked in and they also acknowledged the importance of making working environment mother-friendly for stability and motivation of employed mothers.
Conclusions : Providing mothers with a friendly environment is understood as a positive thing by employers. The current maternity leave of three months has low acceptance and both onsite child care center and six-month maternity leave are believed to help in creating a mother-friendly work environment despite their pros and cons.
Key words : Employer, Breastfeeding, Work environment, Mother-friendly, Employed mothers
Using the Risk Perception Attitude Framework to understand Nasopharyngeal Cancer risk reducing behaviors
Authors: Ting Su-Hie , BRAHMANA Rayenda Khresna , Jerome Collin , Podin Yuwana 
Published: February 2020

Abstract
Background: To reduce deaths due to nasopharyngeal cancer (NPC), it is important to understand factors that predict NPC risk reducing behaviors. This study employed the Risk Perception Attitude (RPA) framework to predict NPC risk reducing behaviors among a group of Malaysians. Methods: A sample of Malaysians (n=215) completed a questionnaire about perceived susceptibility, perceived severity, self-efficacy, response efficacy and intention to enact self-protective actions to reduce NPC risk. Results: A majority of the participants had responsive (high risk, high efficacy) and proactive attitudes (low risk, high efficacy). Hierarchical regression of mediation effect under structural equation model (SEM) approach was used to test the theory. Response efficacy and self-efficacy were negatively associated with perceived risk (p<0.01). Intention was negatively associated with perceived risk and positively associated with response efficacy and self-efficacy (p<0.01). The testing of the indirect effect from perceived risk effect yielded different conclusions for each efficacy measure. For the relationship between perceived risk and intention, there was no mediation effect of response efficacy but the mediation effect of self-efficacy was significant (p<0.1). Heightened perceived risk weakens efficacy beliefs and intention to enact self-protective behavior, suggesting that low risk messages may work better to avert fatalistic thinking for this group. Perceived risk and response efficacy explained 26.5% of the variance in self-efficacy, suggesting the importance of framing NPC risk messages to heighten the audience’s confidence to enact self-protective health behaviors.
Comparative transcriptome analysis of inbred lines and contrasting hybrids reveals overdominance mediate early biomass vigor in hybrid cotton
Authors: Shahzad Kashif , Zhang Xuexian , Guo Liping , Qi Tingxiang , Tang Huini , Zhang Meng , Zhang Bingbing , Wang Hailin , Qiao Xiuqin , Feng Juanjuan , Wu Jianyong , Xing Chaozhu 
Published: February 2020

Abstract
Background: Heterosis breeding is the most useful method for yield increase around the globe. Heterosis is an intriguing process to develop superior offspring to either parent in the desired character. The biomass vigor produced during seedling emergence stage has a direct influence on yield heterosis in plants. Unfortunately, the genetic basis of early biomass vigor in cotton is poorly understood. Results: Three stable performing F1 hybrids varying in yield heterosis named as high, medium and low hybrids with their inbred parents were used in this study. Phenotypically, these hybrids established noticeable biomass heterosis during the early stage of seedling growth in the field. Transcriptome analysis of root and leaf revealed that hybrids showed many differentially expressed genes (DEGs) relative to their parents, while the comparison of inbred parents showed limited number of DEGs indicating similarity in their genetic constitution. Further analysis indicated expression patterns of most DEGs were overdominant in both tissues of hybrids. According to GO results, functions of overdominance genes in leaf were enriched for chloroplast, membrane, and protein binding, whereas functions of overdominance genes in root were enriched for plasma membrane, extracellular region, and responses to stress. We found several genes of circadian rhythm pathway related to LATE ELONGATED HYPOCOTYL (LHY) showed downregulated overdominant expressions in both tissues of hybrids. In addition to circadian rhythm, several leaf genes related to Aux/IAA regulation, and many root genes involved in peroxidase activity also showed overdominant expressions in hybrids. Twelve genes involved in circadian rhythm plant were selected to perform qRT-PCR analysis to confirm the accuracy of RNA-seq results. Conclusions: Through genome-wide comparative transcriptome analysis, we strongly predict that overdominance at gene expression level plays a pivotal role in early biomass vigor of hybrids. The combinational contribution of circadian rhythm and other metabolic process may control vigorous growth in hybrids. Our result provides an important foundation for dissecting molecular mechanisms of biomass vigor in hybrid cotton.
Identification of differentially expressed microRNAs under imidacloprid exposure in Sitobion avenae Fabricius
Authors: Zhang Baizhong , Zhang Shouping , Su Xu , Xie Lanfen , Dong Wen-Yang , Kong Fan-Bin , Liu Junjie , Lu Liuyang , Li Ya-She , Shi Ming-Wang , Chen Xi-Ling , Gao Xi-Wu 
Published: February 2020

Abstract
Background: MicroRNAs (miRNAs), which are short single-stranded non-coding RNAs, regulate the expression of target genes, especially those involved in the regulation or metabolism of endogenous or xenobiotic compounds. Results: De novo assemblies of the transcriptome of Sitobion avenae Fabricius under control conditions and under imidacloprid treatment were obtained using Illumina short-read sequencing technology. Fifty-seven miRNAs, of which 36 were known and 21 were novel, were identified. Quantitative analysis of miRNA levels showed that 5 miRNAs were significantly up-regulated, and 11 miRNAs were significantly down-regulated in the nymphs of S. avenae treated with imidacloprid in comparison with those of the control. Analysis of the candidate target genes in S. avenae that could be regulated by these miRNAs were also carried out. The functions of the miRNAs, which could potentially regulate target genes that participate in metabolism, regulatory or detoxification pathways in S. avenae, were clarified based on Gene Ontology and KEGG pathway analysis. The effects of the miRNAs api-miR-1000, api-miR-316, and api-miR-iab-4 on susceptibility of S. avenae to imidacloprid was determined. Modulation of the abundances of api-miR-1000, api-miR-316, and api-miR-iab-4 by the addition of the correspondign inhibitors to the artificial diet significantly changed the susceptibility of S. avenae to imidacloprid, which further demonstrated the effect of these miRNAs on the regulation or metabolism of insecticides.Conclusion: The results of this study suggested that miRNAs differentially expressed in response to imidacloprid could play a critical regulatory role in the resistance of S. avenae to imidacloprid.
MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis
Authors: Huang Tao , Zhang Jun , Ke Wujian , Zhang Xiaohui , Chen Wentao , Yang Jieyi , Liao Yiwen , Liang Fangwen , Mei Shuqing , Li Mingjiu , Luo Zhenzhou , Zhang Qiwei , Yang Bin , Zheng Heping 
Published: February 2020

Abstract
Background
Treponema pallidum ( T. pallidum ) infection evokes significant immune responses, resulting in tissue damage. The immune mechanism underlying T. pallidum infection is still unclear, although microRNAs (miRNAs) have been shown to influence immune cell function and, consequently, the generation of antibody responses during other microbe infections. However, these mechanisms are unknown for T. pallidum .
Methods
In this study, we performed a comprehensive analysis of differentially expressed miRNAs in healthy individuals, untreated patients with syphilis, patients in the serofast state, and serologically cured patients. miRNAs were profiled from the peripheral blood of patients obtained at the time of serological diagnosis. Then, both the target sequence analysis of these different miRNAs and pathway analysis were performed to identify important immune and cell signaling pathways. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was performed for microRNA analysis.
Results
A total of 89 differentially regulated miRNAs were identified. Following RT-qPCR confirmation, three miRNAs (hsa-miR-195-5p, hsa-miR-223-3p, hsa-miR-589-3p) showed significant differences in the serofast and serologically cured states ( P <0.05). One miRNA (hsa-miR-195-5p) showed significant differences between untreated patients and healthy individuals.
Conclusions
This is the first study of miRNA expression differences in peripheral blood mononuclear cells (PBMCs) in different stages of T. pallium infection. Our study suggests that the combination of three miRNAs has great potential to serve as a non-invasive biomarker of T. pallium infections, which will facilitate better diagnosis and treatment of T. pallium infections.
Considerações sobre o plano de marketing para as microempresas brasileiras
Authors: Kuazaqui Edmir 
Published: February 2020

Este artigo tem o objetivo apresentar os principais conceitos de marketing aplicados pelas microempresas dentro de uma breve contextualização de um plano de marketing. O desenvolvimento e a evolução teórica partiram de pesquisa bibliográfica e da pesquisa de campo e observacional do autor do artigo. O objetivo não é esgotar o assunto nem tampouco construir um Plano de Marketing, mas, sim, de contribuir para a discussão, o aprendizado e a utilização do marketing mix no segmento das microempresas de forma mais assertiva. Concluiu-se que é inegável a importância das microempresas para qualquer país. Sua contribuição reside principalmente na inserção econÿmica e social. Deve-se frisar que as microempresas são as grandes responsáveis pela geração de empregos em nosso país, denotando seu destaque sob a óptica social e ecológica. Mais do que uma forma transitória de ganhar dinheiro, a realidade das microempresas deve ser analisada como um fenÿmeno econÿmico e social capaz de gerar crescimento regional e, consequentemente, global
Análise de projetos mecânico utilizando ferramenta de simulação CAE
Authors: Oliveira Washington Bueno , Ferreira André Rosa 
Published: February 2020

Este estudo visa analisar a frequente quebra do eixo de uma ferramenta utilizada para operações mecânicas de fresagem, para o aumento de sua vida útil e confiabilidade. Será utilizado um software para simulação de CAE, para análise das propriedades mecânicas do material da peça, seus pontos frágeis e os esforços aplicados. Para a viabilidade do estudo houve alterações na geometria da ferramenta e mudança do material utilizado, buscando melhores resultados nas simulações. Serão utilizados quatro materiais para as simulações aço SAE 4340, alumínio 7075, aço SAE 1045 e aço ferramenta tipo A2. A primeira simulação detectou um ponto de fragilidade na estrutura da peça, após a realização das alterações na estrutura e do material, os resultados obtidos apresentaram uma melhora de aproximadamente de 18% na deformação plástica no local de cisalhamento.