bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PENGARUH PERSEPSI MANFAAT, PERSEPSI KEMUDAHAN, DAN KEAMANAN TERHADAP MINAT NASABAH MENGGUNAKAN MOBILE BANKING (Studi Kasus pada PT Bank Rakyat Indonesia (Persero) Tbk Kantor Cabang Semarang Pandanaran)
Authors: Pranoto Margaretha Oktavia , Setianegara R. Gunawan 
Published: December 2020

<p>This research is motivated by the phenomenon of competition in the banking industry in increasing customers interest in using mobile banking. This research aims to analyze the perceived usefulness, perceived ease of use, and security on the interest in using mobile banking at the PT Bank Rakyat Indonesia (Persero) Tbk Branch Office Semarang Pandanaran.<br />The purpose of this study is to describe and analyze the influence customer perceptions of the interest in using mobile banking. This research uses explanatory (explanation) with a quantitative approach, in which customers of Bank Rakyat Indonesia (BRI) branch Semarang Pandanaran as a population, whereas samples taken by 100 respondents were determined by specific criteria. Research results with the t test showed that the variable perceived of usefulness, perceived ease of use and security separately (partial) significantly affects the interest in using mobile banking. Test results also showed that the variables of perceived usefulness, perceived ease of <br />use, and security jointly (simultaneously) significantly affects the interest in using mobile banking. The magnitude of the effect of variable perception of usefulness, perceived ease of use, and security against the interest in using mobile banking is equal to 76.5%, while the rest influenced by other variables that are not addressed in this study.</p>
Wavelet-based Decomposition of Ground Acceleration for Efficient Calculation of Seismic Response in Elastoplastic Structures
Authors: Kamgar Reza , Majidi Noorollah , Heidari Ali 
Published: December 2020

The nonlinear dynamic analysis provides a more accurate simulation of the structural behavior against earthquakes. On the other hand, this analysis method is time-consuming since the time-step integration schemes are used to calculate the responses of the structure. Wavelet transform is also considered as one of the strong computing tools in studying the properties of the waves. The continuous wavelet transform is a time-frequency study and examines the frequency content of the waves while, the discrete wavelet transform is used to reduce sampling data and also to eliminate the noise of the waves. In this paper, the discrete and continuous wavelet transforms are used to reduce the wave sampling and therefore to reduce the required time for analysis. In this regard, eight near- and far- field earthquakes are studied. The frequency content of the earthquake is investigated by the Fourier spectrum and the continuous wavelet transform. The results show that the first five frequencies for the main earthquakes are similar to those values of earthquakes obtained by wavelet transform. Besides, it is shown that using wavelet transform for the main and decomposed earthquakes indicates that the duration of strong ground motion and the time of dominant frequency occur approximately in the same domain. Finally, it is concluded that the required calculation time reduces to about 80 % with an error less than 6 % when the main earthquake is decomposed by wavelet transform and the approximation waves are used in the nonlinear dynamic analysis.
The Effect of Class Management on Grade Five Students Learning Outcome At State Primary School Number 066654 Kelambir V District Tanjung Gusta Medan Helvetia
Authors: Lumbantobing Panni Ance , Panggabean Ruth Donda Eleonora , Nainggolan Maria Friska 
Published: December 2020

This study aims to investigate the effect of classroom management on student learning outcomes at class five primary school numbers 066655, distrcit of Kelambir V Tanjung Gusta Medan Helvetia academic year 2019/2020. The analysis technique in this study is a simple regression technique, observing the relationship or effect between variables. The sample of this research is students of class state primary school number 066654 district of Kelambir V Tanjung Gusta Medan Helvetia, which consists of 2 classes, namely class V A totaling 28 students and class V B totaling 28 students. The total number of class V is 56 students. The variable instrument in the study is all valid, while the reliability for all variables is reliable. Based on the results of statistical analysis, it shows that simple linear regression analysis with the regression equation Y = 24.281 + 0.896X forms a linear line and coefficient of regression direction means. The calculation result is obtained Fcount 56.912 in consultation with Ftable for an error rate of 5%, F table = 4.02. Thus Fcount > F table (56.912 > 4.02) for an error level of 5%. Based on the results of the F test calculation, Fcount is 56.912 with sig = 0.000 <0.005 so that Ho is rejected and Ha is accepted, which means there is an effect of class management (X) which is significant towards learning outcomes (Y). This means that the better the classroom management carried out by the teacher, the higher the student learning outcomes.
A Study of the Implementation of Internalized Interactive Multimedia Learning Models in Life Skills Education of Student at Primary School of it Al-Fitrah Binjai
Authors: Siregar Epi Supriyani 
Published: December 2020

Education is a form of human culture which is a prerequisite for development. Therefore, it is necessary to implement life skills education in learning with the intention of integrating life skills through the implementation of interactive multimedia-based learning models. This study aims to determine the effectiveness of interactive multimedia-based learning models internalized in life skills education that can improve learning outcomes of students in thematic lessons. This research uses a qualitative research approach. Data are analyzed using descriptive analysis techniques to determine the effectiveness of interactive multimedia based learning models in life skills education. The results show that the implementation of an interactive multimedia-based learning model with internalized life skills education involve the realm of personal skills, namely smiling, greeting, and being polite every day in the school environment at primary school of IT Al-Fitrah Binjai. On the other hand, the realm of academic skills involve the variants of learning methods by developing skills that are adjusted to the basic competency standards on the subject of teaching and learning activities. Internalized interactive multimedia-based learning models in life skills education can improve cognitive abilities, affective, and psychomotor students. By internalizing life skills education can improve student learning outcomes, so it is very effective to use.
Implicações do perfil preditivo clínico da neuropatia sensorial periférica induzida por oxaliplatina para o cuidado de enfermagem no câncer da topografia gastrointestinal: estudo observacional descritivo
Authors: Pires Lívia Márcia Vidal , Fuly Patrícia dos Santos Claro 
Published: December 2020

A Oxaliplatina é um medicamento utilizado no tratamento de pacientes oncológicos, principalmente com câncer de colón retal metastático. Porém, ela pode promover o desenvolvimento da Neuropatia Sensorial Periférica (NSP). O objetivo deste estudo é descrever o perfil da preditividade clínica de desenvolvimento da NSP em pacientes expostos à Oxaliplatina, para apoio à prática segura do cuidado de enfermagem nessa toxicidade. A pesquisa foi realizada entre os meses de agosto de 2019 e Março de 2020, com 29 pacientes em tratamento quimioterápico ambulatorial na Central de Quimioterapia Adulto da unidade I do Instituto Nacional de Câncer José Alencar Gomes da Silva, que utilizaram a Oxaliplatina para tratamento de neoplasia na topografia do trato gastrointestinal, sob os protocolos CAPOX e FOLFOX, com idade igual ou superior a 18 anos completos. Foi verificada a prevalência dos fatores clínicos preditivos em ordem decrescente, apontam Diabetes tipo II, Etilismo e Obesidade. O perfil de pacientes que detêm maiores características preditoras de desenvolvimento da NSP induzida por Oxaliplatina é feminino, com idade maior que 60 anos e tão importante quanto a apresentação de comorbidades é a dose cumulativa ao qual estão expostos, suficientes para apresentar manifestações neuropáticas em dose média de 780 mg/m². O reconhecimento dos fatores preditivos, o uso de instrumentos para mensuração do grau de severidade da Neuropatia e a descrição dos eventos agudos e crônicos podem fornecer apoio ao manejo da toxicidade da Oxaliplatina.
Carbon Allocation in Multi-Product Steel Mills That Co‐process Biogenic and Fossil Feedstocks and Adopt Carbon Capture Utilization and Storage Technologies
Authors: Biermann Maximilian , Montañés Rubén M. , Normann Fredrik , Johnsson Filip 
Published: December 2020

This work investigates the effects of carbon allocation on the emission intensities of low-carbon products cogenerated in facilities that co‐process biogenic and fossil feedstocks and apply the carbon capture utilization and storage technology. Thus, these plants simultaneously sequester CO2 and synthesize fuels or chemicals. We consider an integrated steel mill that injects biomass into the blast furnace, captures CO2 for storage, and ferments CO into ethanol from the blast furnace gas. We examine two schemes to allocate the CO2 emissions avoided [due to the renewable feedstock share (biomass) and CO2 capture and storage (CCS)] to the products of steel, ethanol, and electricity (generated through the combustion of steel mill waste gases): 1) allocation by (carbon) mass, which represents actual carbon flows, and 2) a free-choice attribution that maximizes the renewable content allocated to electricity and ethanol. With respect to the chosen assumptions on process performance and heat integration, we find that allocation by mass favors steel and is unlikely to yield an ethanol product that fulfills the Renewable Energy Directive (RED) biofuel criterion (65% emission reduction relative to a fossil comparator), even when using renewable electricity and applying CCS to the blast furnace gas prior to CO conversion into ethanol and electricity. In contrast, attribution fulfills the criterion and yields bioethanol for electricity grid intensities &lt;180 gCO2/kWhel without CCS and yields bioethanol for grid intensities up to 800 gCO2/kWhel with CCS. The overall emissions savings are up to 27 and 47% in the near-term and long-term future, respectively. The choice of the allocation scheme greatly affects the emissions intensities of cogenerated products. Thus, the set of valid allocation schemes determines the extent of flexibility that manufacturers have in producing low-carbon products, which is relevant for industries whose product target sectors that value emissions differently. We recommend that policymakers consider the emerging relevance of co‐processing in nonrefining facilities. Provided there is no double-accounting of emissions, policies should contain a reasonable degree of freedom in the allocation of emissions savings to low-carbon products, so as to promote the sale of these savings, thereby making investments in mitigation technologies more attractive to stakeholders.
A Multi-Method Approach for Quantification of In- and Exfiltration Rates from the Subterranean Estuary of a High Energy Beach
Authors: Grünenbaum Nele , Ahrens Janis , Beck Melanie , Gilfedder Benjamin Silas , Greskowiak Janek , Kossack Michael , Massmann Gudrun 
Published: December 2020

Accurate SGD (submarine groundwater discharge) mass export calculations require detailed knowledge of the spatial and temporal variability in SGD rates. In coastal aquifers, SGD includes a terrestrial freshwater component as well as a saline component originating from circulating seawater. Representative field measurements of SGD rates are difficult to conduct, because SGD is often patchy, diffuse, and temporally variable, especially under tidal influence and high wave activity. In this study, a combination of lysimeters, seepage meters, temperature sensors, pore water radon, and numerical modeling was used to estimate the volumes of infiltrating seawater and exfiltrating groundwater in the intertidal zone of a mesotidal, high energy beach on Spiekeroog Island, northern Germany. Additionally, a 3D-laser scanner was used over short (days) and medium time scales (months) to determine changes in beach topography. The results showed net water infiltration above mean sea level (MSL) and net exfiltration below MSL. Water exchange rates fluctuated between 0.001 and 0.61 m day−1, showing similar ranges within the multiple method approaches. The beach topography was subject to strong fluctuation caused by waves, currents, wind driven erosion and sedimentation, even over short time scales. A comparison of extrapolated in- and exfiltrating water volumes along a beach transect from the mean high water to mean low water line at different times highlights the variability of total in or outflow. The results show that exchange rates depend on beach topography, which in turn changes significantly over time.
MiRNA-Mediated Subpathway Identification and Network Module Analysis to Reveal Prognostic Markers in Human Pancreatic Cancer
Authors: Liu Yuejuan , Cui Yuxia , Bai Xuefeng , Feng Chenchen , Li Meng , Han Xiaole , Ai Bo , Zhang Jian , Li Xuecang , Han Junwei , Zhu Jiang , Jiang Yong , Pan Qi , Wang Fan , Xu Mingcong , Li Chunquan , Wang Qiuyu 
Published: December 2020

BackgroundPancreatic cancer (PC) remains one of the most lethal cancers. In contrast to the steady increase in survival for most cancers, the 5-year survival remains low for PC patients.MethodsWe describe a new pipeline that can be used to identify prognostic molecular biomarkers by identifying miRNA-mediated subpathways associated with PC. These modules were then further extracted from a comprehensive miRNA-gene network (CMGN). An exhaustive survival analysis was performed to estimate the prognostic value of these modules.ResultsWe identified 105 miRNA-mediated subpathways associated with PC. Two subpathways within the MAPK signaling and cell cycle pathways were found to be highly related to PC. Of the miRNA-mRNA modules extracted from CMGN, six modules showed good prognostic performance in both independent validated datasets.ConclusionsOur study provides novel insight into the mechanisms of PC. We inferred that six miRNA-mRNA modules could serve as potential prognostic molecular biomarkers in PC based on the pipeline we proposed.
Identification of a Rare and Potential Pathogenic MC4R Variant in a Brazilian Patient With Adulthood-Onset Severe Obesity
Authors: Salum Kaio Cezar Rodrigues , de Souza Guilherme Orofino , Abreu Gabriella de Medeiros , Campos Junior Mário , Kohlrausch Fabiana Barzotto , Carneiro João Regis Ivar , Nogueira Neto José Firmino , Magno Fernanda Cristina C. Mattos , Rosado Eliane Lopes , Palhinha Lohanna , Maya-Monteiro Clarissa Menezes , Cabello Giselda Maria Kalil de , Cabello Pedro Hernán , Bozza Patrícia Torres , Zembrzuski Verônica Marques , da Fonseca Ana Carolina Proença 
Published: December 2020

BackgroundThe melanocortinergic pathway orchestrates the energy homeostasis and impairments in this system often lead to an increase in body weight. Rare variants in the melanocortin 4 receptor (MC4R) gene resulting in partial or complete loss of function have been described with autosomal co-dominant inheritance. These mutations are the most common cause of non-syndromic monogenic obesity. In this context, this study aimed to sequence the MC4R gene in a Brazilian cohort of adults with severe obesity.MethodsThis study included 163 unrelated probands with Body Mass Index (BMI) ≥ 35 kg/m2, stratified into three groups, according to the period of obesity onset. From the total sample, 25 patients were enrolled in the childhood-onset group (0–11 years), 19 patients in the adolescence/youth-onset group (12–21 years), and 119 patients in the adult-onset group (&gt;21 years). Blood pressure, anthropometric and biochemical characteristics were obtained, and the MC4R coding region of each subject’s DNA was assessed using automated Sanger sequencing.ResultsSignificant anthropometric differences between the groups were observed. Higher body weight and BMI medians were found in patients with childhood-onset or adolescence/youth-onset when compared to the adulthood-onset obesity group. A total of five mutations were identified, including four missense variants: p.Ser36Thr, p.Val103Ile, p.Ala175Thr, and p.Ile251Leu. Additionally, we observed one synonymous variant (p.Ile198=). The p.Ala175Thr variant was identified in a female case with severe obesity and adulthood-onset. This variant was previously described as a partial loss-of-function mutation, in which the minor allele poses dominant-negative effect, probably resulting in reduced cAMP activity.ConclusionThis study showed a prevalence of common and rare variants in a cohort of Brazilian adults with severe obesity and candidates to bariatric surgery. We have identified a rare potentially pathogenic MC4R variant in a Brazilian patient with severe and adulthood-onset obesity.
Intravenous Tissue Plasminogen Activator in Combination With Mechanical Thrombectomy: Clot Migration, Intracranial Bleeding, and the Impact of “Drip and Ship” on Effectiveness and Outcomes
Authors: Chang Adam , Beheshtian Elham , Llinas Edward J. , Idowu Oluwatoyin R. , Marsh Elisabeth B. 
Published: December 2020

Purpose: Intravenous tissue plasminogen activator (tPA) is indicated prior to mechanical thrombectomy (MT) to treat large vessel occlusion (LVO). However, administration takes time, and rates of clot migration complicating successful retrieval and hemorrhagic transformation may be higher. Given time-to-effectiveness, the benefit of tPA may vary significantly based on whether administration occurs at a thrombectomy-capable center or transferring hospital.Methods: We prospectively evaluated 170 individuals with LVO involving the anterior circulation who underwent MT at our Comprehensive Stroke Center over a 3.5 year period. Two thirds (n = 114) of patients were admitted through our Emergency Department (ED). The other 33% were transferred from outside hospitals (OSH). Patients meeting criteria were bridged with IV tPA; the others were treated with MT alone. Clot migration, recanalization times, TICI scores, and hemorrhage rates were compared for those bridged vs. treated with MT alone, along with modified Rankin scores (mRS) at discharge and 90-day follow-up. Multivariable regression was used to determine the relationship between site of presentation and effect of tPA on outcomes.Results: Patients presenting to an OSH had longer mean discovery to puncture/recanalization times, but were actually more likely to receive IV tPA prior to MT (70 vs. 42%). The rate of clot migration was low (11%) and similar between groups, though slightly higher for those receiving IV tPA. There was no difference in symptomatic ICH rate after tPA. TICI scores were also not significantly different; however, more patients achieved TICI 2b or higher reperfusion (83 vs. 67%, p = 0.027) after tPA, and TICI 0 reperfusion was seen almost exclusively in patients who were not treated with tPA. Those bridged at an OSH required fewer passes before successful recanalization (2.4 vs. 1.6, p = 0.037). Overall, mean mRS scores on discharge and at 90 days were significantly better for those receiving IV tPA (3.9 vs. 4.6, 3.4 vs. 4.4 respectively, p ~ 0.01) and differences persisted when comparing only patients recanalized in under 6 h.Conclusion: Independent of site of presentation, IV tPA before MT appears to lead to better radiographic outcomes, without increased rates of clot migration or higher intracranial hemorrhage risk, and overall better functional outcomes.
Risk Factors for Adult Depression: Adverse Childhood Experiences and Personality Functioning
Authors: Dagnino Paula , Ugarte María José , Morales Felipe , González Sofia , Saralegui Daniela , Ehrenthal Johannes C. 
Published: December 2020

Background: Depressive disorder is one of the main health problems worldwide. Many risk factors have been associated with this pathology. However, while the association between risks factors and adult depression is well established, the mechanisms behind its impact remains poorly understood. A possible, yet untested explanation is the mediating impact of levels of personality functioning, i.e., impairments with regard to self and interpersonal.Method: Around 162 patients were assessed at the beginning of their therapy, with regard to risk factors, such as sociodemographic, physical, hereditary (Information Form), and adverse childhood experiences (ACE; CTQ). Depressive symptoms (Beck Depression Inventory, BDI) and personality functioning (OPD-SQ) were also measured. Associations between the related variables as well as other possible covariates were examined by means of zero-order correlations and bootstrapping-based mediation analysis.Results: Of all the risk factors taken into account, level of education and physical illness were associated with depression. On the other hand, the most significant predictor of depressive symptomatology was ACE, and this relationship was mediated by personality functioning. This indicates that patients presenting adverse childhood experiences are more likely to develop deficiencies in personality functioning, which in turn increases their likelihood of developing depressive symptomatology.Conclusion: These results reaffirm the importance of incorporating risk and vulnerability factors such as personality functioning in understanding depression.