bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo three-dimensional mandibular kinematics and functional point trajectories during temporomandibular activities using 3d fluoroscopy
Authors: Chen Chien-Chih , Lin Cheng-Chung , Hsieh Hong-Po , Fu Yang-Chieh , Chen Yunn-Jy , Lu Tung-Wu 
Published: August 2020

Objectives: To measure in vivo three-dimensional kinematics of the mandible and associated end-point trajectories and to quantify their relationships during temporomandibular joint activities using 3D fluoroscopy. Methods: A novel fluoroscopy-based 3D measurement method was used to measure motions of the mandible and the associated end points (i.e. incisors and lateral poles of both condyles) during open close, lateral gliding and protrusion-retraction movements in healthy young individuals. The contributions of each of the rotational and translational components of the mandible to the end-point trajectories were quantified through experiment-based computer simulations. Results: The mandibular rotation was found to account for 91% of the maximal mouth-opening-capacity and 73% of the maximal lateral incisor movement, while the condylar translation contributed to 99% of the anterior protrusion distance. Incisor trajectories were nearly vertical within the first 60% of the maximal opening during the open-close movement. Conclusions: Similar condylar downward rotation paths but with bilaterally asymmetrical ranges were used to perform basic mandibular movements of different targeted TI trajectories in three dimensions, that is, open-close, lateral-gliding and protrusion-retraction. Mandibular rotations contributed to the majority of the principal displacement components of the incisor, that is, vertical during open-close and towards the working-side-during lateral-gliding, while mandibular translation contributed mainly to the forward movement of the incisor during protrusion-retraction. Owing to the anatomical constraints, the freedom of mandibular translation is limited and mainly in the anteroposterior direction, which is considered helpful for the control and stability of the TMJ during oral activities.
Ciência é tudo
Authors: Tonelli Maria José , Wilner Adriana , Dos Santos Aline Lilian 
Published: August 2020

Recém-empossado como diretor científico da Fundação de Amparo à Pesquisa do Estado de São Paulo (Fapesp), uma das principais agências de fomento à pesquisa científica e tecnológica do país, Luiz Eugênio Mello tem um perfil diferente do de seus antecessores.Além de médico e pesquisador de primeira linha na Universidade Federal de São Paulo (Unifesp), Luiz tem passagem pela iniciativa privada. Foi diretor de tecnologia e inovação da Vale e responsável pela implantação do Instituto Tecnológico Vale. Mais recentemente, foi também diretor de pesquisa e desenvolvimento do Instituto D’Or de Pesquisa e Ensino (IDOR), braço do maior grupo privado de hospitais do país, a Rede D’Or São Luiz. Ele acredita que essa experiência híbrida enriquece sua visão em relação às possibilidades que a ciência oferece e tem planos de marcar sua gestão unindo esses dois mundos, que, em sua opinião, compõem a base da riqueza das nações. A própria pandemia do coronavírus vem mostrando, segundo Luiz, como é importante aproximar pesquisadores e empresas para trazer avanços à sociedade.Nesta entrevista exclusiva à GV-executivo, o novo diretor da Fapesp também fala sobre o corte de recursos na área de pesquisa, as perspectivas do segmento no país e a importância da inovação nesse contexto. Por fim, Luiz dá algumas orientações a quem pretende seguir carreira no meio científico.
Cartas da FGV
Authors: Leal Carlos Ivan Simonsen , Brito Luiz Artur Ledur 
Published: August 2020

Em pouco tempo, conseguimos enfrentar os desafios que nos foram impostos por essa emergência internacional e continuar o trabalho focado no cumprimento de nossa missão, que é contribuir para o desenvolvimento do Brasil. Isso não seria possível sem os colaboradores, professores e alunos da Fundação Getulio Vargas (FGV), que foram extremamente empenhados e resilientes diante das mudanças ocorridas nesse difícil período.Carlos Ivan Simonsen Leal Em consonância com a mobilização geral da Fundação Getulio Vargas (FGV), a Escola de Administração de Empresas de São Paulo (EAESP) conseguiu manter o funcionamento de todas as suas atividades, convertendo-as ao modo remoto de forma muito rápida, eficiente e com alta qualidade. Estamos orgulhosos de nossa reação diante do cenário atual, o que nos coloca nos melhores patamares internacionais de resposta a esse desafio global. Seguimos, contudo, atentos às adversidades e à necessidade de nos adaptarmos e nos reinventarmos constantemente. Luiz Artur Ledur Brito
Novos olhares para o agora e o amanhã
Authors: Tonelli Maria José , Wilner Adriana 
Published: August 2020

Vivemos, incrédulos, essa pandemia que nos coloca fora de uma suposta inalterabilidade do nosso cotidiano. Somos desafiados a olhar de outra forma para nossas casas, nosso trabalho, nosso entorno, nossos ecossistemas, nosso governo, nossas empresas, nossa sociedade e a refletir sobre nós mesmos e nosso mundo. É um momento em que a gestão sobressalta. Dependemos de como nos organizamos para combater a doença e suas consequências. Esta edição especial da GV-executivo trata de como gerenciar a crise e de como se preparar para o que virá depois, em suas várias facetas, no sistema de saúde, na economia, no combate ao desemprego e à desigualdade social, nas relações internacionais, na área pública, no meio ambiente, nos recursos humanos, em como trabalhar, na maneira de liderar, nas finanças, nas cadeias de suprimentos, no marketing, no varejo, nas ações de solidariedade.
Anxiety among Doctors during COVID-19 Pandemic in Secondary and Tertiary Care Hospitals
Authors: Hasan Syed Riazul , Hamid Zeeshan , Jawaid Muhammad Talha , Ali Rashida Kaizar 
Published: August 2020

Objective: To assess the level of anxiety among doctors during COVID-19 pandemic and the associated risk factors.
Methods: This cross-sectional study was conducted from 30th April to 16th May, 2020 in Karachi, Pakistan. The data was collected via an online web-based questionnaire. Questionnaire was used to assess anxiety level using GAD-7 scale among health-care professionals and the risk factors playing role in it.
Results: One hundred and fifty-one doctors participated in our study. Out of these 151 participants, 69 (45.7%) had mild, 22 (14.6%) had moderate, and 5 (3.3%) had severe symptoms of anxiety, whereas the remaining 55 (36.4%) had no anxiety according to GAD-7 scale. The median [interquartile range (IQR)] GAD-7 scale scores are 6.0 [3.00-9.00]. Females showed more severe degrees of measurement of anxiety symptoms than males. Doctors dealing with COVID-19 patients showed higher level of anxiety as compared to the doctors who were not dealing with COVID-19 patients, having a significant difference (U = 9.697, p = 0.008). One hundred and forty-one (93.4%) participants were concerned about being exposed to COVID-19 at work and 112 (74.2 %) thought they have inadequate protective equipment for safety.
Conclusions: During COVID-19 pandemic, doctors exhibited different grades of anxiety. In order for healthcare workers to perform to the best of their capability, certain guidelines and interventions are needed.
doi: https://doi.org/10.12669/pjms.36.6.3113
How to cite this:Hasan SR, Hamid Z, Jawaid MT, Ali RK. Anxiety among Doctors during COVID-19 Pandemic in Secondary and Tertiary Care Hospitals. Pak J Med Sci. 2020;36(6):1360-1365. doi: https://doi.org/10.12669/pjms.36.6.3113
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Views on social media and its linkage to longitudinal data from two generations of a UK cohort study
Authors: Di Cara Nina H. , Boyd Andy , Tanner Alastair R. , Al Baghal Tarek , Calderwood Lisa , Sloan Luke S. , Davis Oliver S. P. , Haworth Claire M. A. 
Published: August 2020

Background: Cohort studies gather huge volumes of information about a range of phenotypes but new sources of information such as social media data are yet to be integrated. Participant’s long-term engagement with cohort studies, as well as the potential for their social media data to be linked to other longitudinal data, may give participants a unique perspective on the acceptability of this growing research area. Methods: Two focus groups explored participant views towards the acceptability and best practice for the collection of social media data for research purposes. Participants were drawn from the Avon Longitudinal Study of Parents and Children cohort; individuals from the index cohort of young people (N=9) and from the parent generation (N=5) took part in two separate 90-minute focus groups. The discussions were audio recorded and subjected to qualitative analysis. Results: Participants were generally supportive of the collection of social media data to facilitate health and social research. They felt that their trust in the cohort study would encourage them to do so. Concern was expressed about the collection of data from friends or connections who had not consented. In terms of best practice for collecting the data, participants generally preferred the use of anonymous data derived from social media to be shared with researchers. Conclusion: Cohort studies have trusting relationships with their participants; for this relationship to extend to linking their social media data with longitudinal information, procedural safeguards are needed. Participants understand the goals and potential of research integrating social media data into cohort studies, but further research is required on the acquisition of their friend’s data. The views gathered from participants provide important guidance for future work seeking to integrate social media in cohort studies.
Non-native fold of the putative VPS39 zinc finger domain
Authors: Butt Benjamin G. , Scourfield Edward J. , Graham Stephen C. 
Published: August 2020

Background: The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is involved in regulating the fusion of late endosomes and autophagosomes with lysosomes in eukaryotes. The C-terminal regions of several HOPS components have been shown to be required for correct complex assembly, including the C-terminal really interesting new gene (RING) zinc finger domains of HOPS components VPS18 and VPS41. We sought to structurally characterise the putative C-terminal zinc finger domain of VPS39, which we hypothesised may be important for binding of VPS39 to cellular partners or to other HOPS components. Methods: We recombinantly expressed, purified and solved the crystal structure of the proposed zinc-binding region of VPS39. Results: In the structure, this region forms an anti-parallel β-hairpin that is incorporated into a homotetrameric eight-stranded β-barrel. However, the fold is stabilised by coordination of zinc ions by residues from the purification tag and an intramolecular disulphide bond between two predicted zinc ligands. Conclusions: We solved the structure of the VPS39 C-terminal domain adopting a non-native fold. Our work highlights the risk of non-native folds when purifying small zinc-containing domains with hexahistidine tags. However, the non-native structure we observe may have implications for rational protein design.
The 33⅓ B-Sides, Will Stockton and D. Gilson (eds) (2019)
Authors: Bestley Russ 
Published: August 2020

Review of: The 33⅓ B-Sides, Will Stockton and D. Gilson (eds) (2019)
London: Bloomsbury, 250 pp.,
ISBN 978-1-50134-294-3, h/bk, £15.99
Venous thromboembolism in patients with adrenocortical carcinoma after surgery
Authors: Durmuşoğlu Jülide , Timmers Henri J L M , van Houten Pepijn , Langenhuijsen Hans F , Hermus Ad R M M , van de Ven Annenienke C 
Published: August 2020

Background:
Adrenocortical carcinoma is a rare malignancy with a poor prognosis. We hypothesized that patients with adrenocortical carcinoma are at high risk for venous thromboembolism, given the numerous risk factors such as malignancy, abdominal surgery, immobility and hormonal excess. The aim of this study was to determine retrospectively the incidence of venous thromboembolisms after surgical treatment in patients with adrenocortical carcinoma.

Materials and methods:
A retrospective study was performed, collecting data from all patients diagnosed with adrenocortical carcinoma from 2003 to 2018 at the Radboud University Medical Centre, The Netherlands.

Results:
In 34 patients, eight postoperative venous thromboembolisms, all pulmonary embolisms, were diagnosed in the first 6 months after adrenalectomy (23.5%). In addition, one patient developed pulmonary embolism just prior to surgery and one patient 7 years after surgery. Five of the eight patients with postoperative venous thromboembolisms presented with symptomatic pulmonary embolism whereas the other three pulmonary embolisms were incidentally found on regular follow up CT scans. Seven of the eight venous thromboembolisms occurred within 10 weeks after surgery. Seven of the eight patients had advanced stage adrenocortical carcinoma and four patients already received low-molecular weight heparin during the development of the venous thromboembolism. There was one case of fatal pulmonary embolism in a patient with a cortisol producing tumor with pulmonary metastases, despite the use of a therapeutic dose thromboprophylaxis.

Conclusion:
Patients with adrenocortical carcinoma are at high risk of developing postoperative venous thromboembolisms. Prolonged postoperative thromboprophylaxis could be considered in these patients.
Severe Dilated Cardiomyopathy Resulted from a Large Single Coronary Artery Fistula Drained Into the Left Ventricle
Authors: Lee Seung Hun , Cho Jae Young , Sho Ho Sung , Yu Cheol Woong 
Published: August 2020

Background: Coronary artery fistula (CAF) draining into the left ventricle (LV) is a rare condition and dilated cardiomyopathy (DCMP) that results from single coronary artery (SCA) accompanied by CAF also is extremely rare.
Case report: We report the case of a 36-year-old man, who presented with severe DCMP that resulted from SCA with CAF draining into the LV. Transthoracic echocardiogram (TTE) showed severe diffuse hypokinesia of the LV with ejection fraction (EF) of 15-20%. Coronary angiography (CAG) revealed SCA connected between left anterior descending artery (LAD) and posterior descending artery (PDA), course of the PDA was very tortuous from apex to base of the LV, and connected to posterior lateral (PL) branch, which was drained into the LV at distal part of the PL. Coronary artery computed tomography (CACT) showed LAD ran over the apex of the LV and connected to PDA, which was drained into the mid portion of lateral wall of the LV. Cardiac magnetic resonance imaging (CMRI) showed no evidence of irreversible myocardial change in global wall of the LV. The patient underwent surgical ligation of PDA near the base of the posterior wall of the LV as close to the entry of CAF to the LV as possible without any surgery-related complications. Three months after the surgical ligation, follow-up TEE showed much improved EF of 45-50%. He has been doing well without congestive heart failure (CHF) until now.
Discussion: Symptomatic CAF with hemodynamic deterioration may need mechanical correction of CAF, including surgical ligation or percutaneous interventional occlusion. How to treat this condition in terms of methodology is a very difficult issue. The detailed methods related to surgical or interventional correction of CAF have to be determined based on anatomical characteristics of CAF, underlying comorbidities, and relevant complications risk.
Efecto de la criopreservación en la integridad acrosomal de espermatozoides viables de alpaca evaluada mediante citometría de flujo
Authors: Pérez-Rosales María , Román Brian , Santiani Alexei 
Published: August 2020

El objetivo del presente estudio fue determinar el efecto de la criopreservación sobre la integridad acrosomal en espermatozoides viables de alpaca. Se procesaron muestras de 46 testículos de alpaca que presentaron una motilidad >30% y concentración espermática >50x106 espermatozoides/ml. Los espermatozoides recuperados de la cola del epidídimo se separaron en dos alícuotas de 500 µl. La primera alícuota fue para la evaluación inicial en fresco y la segunda alícuota se congeló en pajillas que fueron almacenadas en nitrógeno líquido hasta el día de su evaluación. Para la evaluación de viabilidad e integridad acrosomal, 100 µl de cada muestra fueron incubadas con 2.5 µl de FITC-PSA (100 µg/ml) y 0.5 µl de ioduro de propidio (PI, 2.4 mM) por 10 min a 38 °C. Inmediatamente después, las muestras se evaluaron por citometría de flujo, adquiriéndose diez mil eventos compatibles con espermatozoides por muestra. FITC-PSA y PI fueron excitados con un láser de 488 nm, y la emisión de fluorescencia fue detectada utilizando los canales Ch02 (505-560 nm) para FITC-PSA y Ch05 (642-740nm) para PI. Se determinó el porcentaje de espermatozoides con integridad acrosomal (FITC-PSA negativos) de la población de espermatozoides viables (PI negativos). Se utilizó la prueba de los rangos con signos de Wilcoxon para determinar como la criopreservación afecta la integridad acrosomal en los espermatozoides viables. Se encontró que la integridad acrosomal de los espermatozoides viables frescos (98.25 ± 5.41%) fue similar a la de los espermatozoides viables pos-descongelamiento (98.75 ± 2.17%). Se concluye que los espermatozoides viables de alpaca antes y después del proceso de criopreservación mantienen un elevado porcentaje de integridad acrosomal.
Un sistema de co-cultivo con células del cumulus oophurus mejora la calidad de embriones bovinos producidos in vitro
Authors: Guevara-Chacón Susana , Quispe-Ccasa Hurley Abel , Saucedo-Uriarte José Américo , Cayo-Colca Ilse Silvia 
Published: August 2020

El estudio tuvo como objetivo determinar la influencia de un sistema de co-cultivo con células del cumulus oophorus sobre la calidad de embriones bovinos producidos in vitro en función a su viabilidad. Se utilizaron ovarios de bovinos hembra cruzadas, sacrificadas en el Centro de Beneficio Municipal de Chachapoyas, Amazonas, Perú. Los ovocitos aspirados de folículos de 2-6 mm fueron madurados en medio TCM-199 por 24 horas, en una atmósfera humidificada con 6% de CO2 y a 38.5 °C. El estado de maduración fue determinado mediante el estadio nuclear a través de tinción aceto-orceína. Los ovocitos maduros se fertilizaron in vitro con semen congelado de toros Angus durante 18 horas. Los presuntos cigotos fueron distribuidos aleatoriamente para su desarrollo en un grupo en medio con co-cultivo y otro en medio sin co-cultivo (control). Se determinó la calidad embrionaria en función a la actividad enzimática y daño al ADN de los embriones al séptimo día del cultivo, mediante los fluorocromos diacetato de fluoresceína (FDA) y yoduro de propidio (PI), respectivamente. No se encontró asociación significativa (p>0.05) en la cantidad de embriones producidos in vitro, pero hubo diferencia significativa en viabilidad embrionaria a favor del sistema con co-cultivo (p<0.05). El uso de co-cultivos con células de cumulus oophurus mejora la viabilidad y, por lo tanto, la calidad embrionaria, sin influir en la tasa de producción de embriones in vitro.
Accuracy of dynamic three-dimensional magnetic resonance perfusion imaging for the detection of coronary artery disease in patients with reduced ejection fraction
Authors: Oebel Sabrina , Gotschy Alexander , Paetsch Ingo , Jahnke Cosima , Plein Sven , Gebker Rolf , Hamada Sandra , Frick Michael , von Spiczak Jochen , Polacin Malgorzata , Enseleit Frank , Marx Nikolaus , Lüscher Thomas F. , Ruschitzka Frank , Kozerke Sebastian , Alkadhi Hatem , Manka Robert 
Published: August 2020

AbstractBackgroundTo assess the accuracy of 3D cardiovascular magnetic resonance (CMR) perfusion imaging for the detection of coronary artery disease (CAD) against fractional flow reserve (FFR) and quantitative coronary angiography (QCA) in patients with reduced ejection fraction (EF).MethodsOut of 447 patients who underwent 3D CMR perfusion imaging (at 1.5 and 3.0 T under adenosine stress and at rest) at 5 European centers, 86 cases with an EF ≤50% were identified (mean age 64 ± 11 yrs, 80% male). Significant CAD was defined as a FFR value <0.8 and a QCA >50%. 86 individuals matched for age, gender and major cardiovascular risk factors, were chosen as the control group.ResultsThe prevalence of CAD defined by FFR (<0.8) was 59% (EF≤50%) vs. 54% (EF>50%), P = 0.4). In relation to FFR, 3D perfusion imaging yielded a sensitivity of 84.5% (95% CI 76.0–90.4) and specificity of 77.3% (95% CI 66.7–85.3). The sensitivity of perfusion imaging was higher in patients with an EF≤50% (90.2 vs. 78.3%, P = 0.1) whereas specificity showed the reverse (62.9 vs. 90.0%, P = 0.005) The diagnostic accuracy was comparable in both subgroups (AUC 79.1 vs. 83.7%, P = 0.25). According to QCA, the prevalence of CAD was 78 vs. 72% (P = 0.4). Perfusion imaging yielded a sensitivity and specificity of 82.1 vs. 62.9%, P = 0.01 and 79.0 vs. 95.8%, P = 0.09 respectively with a high diagnostic accuracy in both subgroups (AUC 82.0 vs. 80.5%).Conclusion3D-CMR perfusion imaging yields a high sensitivity and diagnostic accuracy with regards to the detection of significant CAD irrespective of left ventricular (LV) systolic function.
PERIKANAN BUDIDAYA DI DANAU MANINJAU: Antisipasi Kebijakan Penanganan Dampak Kematian Masal Ikan
Authors: Nasution Zahri , Sari Yesi Dewita , Huda Hakim Miftakhul 
Published: August 2020

Kematian ikan secara massal sebanyak 950 ton di Danau Maninjau, Sumatera Barat yang pertamakali terjadi pada tahun 1997, mengakibatkan kerugian sebesar Rp. 2,7 milyar. Kematian massal selanjutnya terjadi pada awal Januari 2009 dan terulang kembali pada akhir Februari serta awal Maret 2010 dengan tingkat kematian ikan mencapai 1.150 ton. Kajian ini bertujuan untuk menganalisa opsi kebijakan antisipasi dalam penanganan dampak kematian massal ikan di Danau Maninjau. Kajian ini dilakukan menggunakan pendekatan analisis kebijakan dengan hasil bahwa dampak ekonomi kematian massal ikan budidaya yang terjadi pada dua (2) nagari di Danau Maninjau pada periode 23 Februari – 13 Maret 2010 mengakibatkan kerugian finansial sebesar Rp 13,93 milyar bagi para pembudidaya ikan. Kerugian tersebut terdiri atas dampak kerugian ekonomi kematian ikan, potensi keuntungan yang hilang bagi pembudidaya ikan, pedagang pakan ikan dan pedagang ikan. Dampak sosial yang diperhitungkan secara ekonomi adalah hilangnya sumber mata pencaharian, sejumlah tenaga kerja dalam tata niaga budidaya ikan sistem karamba jaring apung (KJA) bersumber dari adanya peningkatan hutang untuk melanjutkan usaha. Kajian ini menghasilkan lima opsi antisipasi kebijakan dalam penanganan dampak kematian massal ikan di Danau Maninjau. Title: Aquaculture in Lake Maninjau: Policy Anticipation to Handle Impacts of Fish Kills Massive fish kills with about 950 tons in Lake Maninjau of West Sumatra was firstly occurred in 1997 impacted a financial loss of IDR 2.7 billion. Further fish kills were occurred in early January 2009 and were followed in late February and early March 2010 with number of 1,150 tons fish kills. This research aims to analyze options for policy anticipation to handle impacts of fish kills in Lake Maninjau. This research used a policy analysis approach and the results showed that the economic impacts of fish kills in two villages during 23 February to 13 March 2010 accounted for IDR 13.93 billion. Economic loss consists of the fish kills impacts including potential profit loss from fish farmers, traders, fish feed and fish traders. Calculated social impacts in economic terms were a loss number of livelihood and source of incomes from floating net cage aquaculture by which lead to debt increasing. This research produced five options for policy anticipation to handle impacts of fish kills.