bluuebunny/crossref_metadata_2025_split huggingface dataset:
POCIS Calibration for Organic Compound Sampling in Small Headwater Streams
Authors: Booij Kees , Chen Sunmao , Trask Jennifer R. 
Published: May 2020

Abstract
Field-based atrazine sampling rates (Rs) obtained by the polar organic chemical integrative sampler (POCIS) method were measured in 9 headwater streams over 3 yr covering 5 to 6 exposure periods of 2 to 3 wk/site/yr. Rates were best in line with the model Rs = 148 mL/d, with a standard deviation of 0.17 log units (factor 1.5). The POCIS canisters reduced mass transfer coefficients of the water boundary layer by a factor of 2 as measured by alabaster dissolution rates. A mechanistic model that accounts for flow and temperature effects yielded a fair estimate of the effective exchange surface area (12.5 ± 0.8 cm2). This model could only be tested for higher flow velocities because of uncertainties associated with the measurement of flow velocities &lt;1 cm/s. Pictures of sorbent distributions in POCIS devices showed that the effective exchange surface area varied with time during the exposures. Error analysis indicated that sorbent distributions and chemical analysis were minor error sources. Our main conclusion is that an atrazine sampling rate of 148 mL/d yielded consistent results for all 3 yr across 9 headwater streams. Environ Toxicol Chem 2020;39:1334–1342. © 2020 SETAC
Abstract
Polar organic chemical integrative sampler (POCIS)-based atrazine aqueous concentrations (Cw) were consistent with concentrations from daily composite water sampling in 9 headwater streams over 3 yr.
Effects of different thawing methods on flavor compounds and sensory characteristics of raspberry
Authors: Liu Lu , Lv Chunmao , Meng Xianjun , Xin Guang , Li Bin 
Published: May 2020

AbstractIn order to identify more suitable thawing method to preserve aroma, taste, and other sensory quality of raspberry, five thawing methods were used to treat frozen raspberry, namely water bath thawing, microwave thawing, ultrasonic thawing, room temperature thawing, and refrigeration thawing. Gas chromatography‐mass spectrometry was employed to study the quantitative and qualitative analysis of the volatile compounds, and the characteristic flavor components of raspberry were compared by relative odor activity value (ROAV). Electronic tongue technique and fuzzy comprehensive evaluation were used to ensure the changes in sensory qualities of raspberry. The results showed that the time of microwave thawing was 0.57 minutes, and drip loss was 4.40%. Both of them were the lowest among the five thawing methods. The volatile components of raspberry included aldehydes, esters, ketones, alcohols, fatty acids, terpenes, and other compounds. Among them, there were 19 kinds of volatile components in quick‐frozen raspberries, 18 volatile components in raspberries after treated by microwave thawing and refrigeration thawing, 16 volatile components after room temperature thawing, 12 volatile components after ultrasonic thawing, and 10 volatile components after water bath thawing. The characteristic flavor compounds of raspberry were identified as acetaldehyde, alpha‐ionone, beta‐ionone, raspberry ketone, alpha‐terpene, and alpha‐pinene. Microwave thawing was the most suitable way to preserve the characteristic flavor components of raspberry, but water bath thawing could destroy the most of compounds. After microwave thawing, raspberry tasted best and was most acceptable to consumers. Therefore, microwave thawing was the most appropriate method to preserve raspberry flavor and sensory quality among the five thawing methods.
Significant association between host transcriptome‐derived HPV oncogene E6* influence score and carcinogenic pathways, tumor size, and survival in head and neck cancer
Authors: Qin Tingting , Koneva Lada A. , Liu Yidan , Zhang Yanxiao , Arthur Anna E. , Zarins Katie R. , Carey Thomas E , Chepeha Douglas , Wolf Gregory T. , Rozek Laura S. , Sartor Maureen A. 
Published: May 2020

AbstractBackgroundHuman papillomavirus (HPV) oncogenes E6, E7, and shorter isoforms of E6 (E6*) are known carcinogenic factors in head and neck squamous cell carcinoma (HNSCC). Little is known regarding E6* functions.MethodsWe analyzed RNA‐seq data from 68 HNSCC HPV type 16‐positive tumors to determine host genes and pathways associated with E6+E7 expression (E6E7) or the percent of full‐length E6 (E6%FL). Influence scores of E6E7 and E6%FL were used to test for associations with clinical variables.ResultsFor E6E7, we recapitulated all major known affected pathways and revealed additional pathways. E6%FL was found to affect mitochondrial processes, and E6%FL influence score was significantly associated with overall survival and tumor size.ConclusionsHPV E6E7 and E6* result in extensive, dose‐dependent compensatory effects and dysregulation of key cancer pathways. The switch from E6 to E6* promotes oxidative phosphorylation, larger tumor size, and worse prognosis, potentially serving as a prognostic factor for HPV‐positive HNSCC.
Parents’ concerns about Leavers celebrations: A cross‐sectional study
Authors: Lombardi Karen , Gregory Sonia , Johnston Robyn , Gilligan Conor , Beatty Shelley , Thomas Laura , Shaw Therese 
Published: May 2020

AbstractIssue Addressed“Schoolies’ or “Leavers’ is a mass celebration of the end of compulsory schooling where excessive drinking is considered integral to the experience. Leavers are at risk of alcohol‐related harms. This paper reports the concerns of parents for their Year 12 students (age 17 years) when attending Leavers celebrations.MethodsParents of Year 12 students (n = 87) were asked to complete a survey in relation to their eldest school‐aged child. Six items relating to parents’ level of “concern’ about Leavers celebrations were measured on a 5‐point scale.ResultsParents were concerned about their child experiencing peer pressure to consume alcohol (60%), 30% were neutral or unconcerned about peer pressure. Almost two thirds of parents were concerned about their child being injured as a result of their own alcohol use (66.7%). Parental concern relating to their child being injured because of others’ alcohol use rated most highly (88.5%).ConclusionsFindings suggested that parents were more concerned with harm caused to their child by others than the use of alcohol by their own child. Parents were somewhat less concerned with peer pressure to drink, though given peer influence is a major factor in young people's decisions regarding alcohol, parents' apparent confidence in their children's capacity to resist peer pressure may be inflated.So What?Future interventions reinforcing the important role that parents play in the decisions that young people make while at Leavers have the potential to reduce their alcohol intake and subsequent alcohol‐related harm.
Decision making for promising quinoline‐based anticancer agents through combined methodology
Authors: Özcan Evrencan , Ökten Salih , Eren Tamer 
Published: May 2020

AbstractDuring the development of effective drugs for the treatment of cancer, one of the most important tasks is to identify effective drug candidates having maximum antiproliferation and minimum side effects. This paper considers the problem of selecting the most promising anticancer agents, showing inhibition at low IC50 concentration and low releasing lactate dehydrogenase percentage (cytotoxicity). Recently, we prepared quinoline analogs bearing different functional groups and determined their anticancer potential against the HeLa, C6, and HT29 cancer cell lines using different anticancer assays. Experimentally, seven quinoline derivatives consisting of different substituents were determined as promising anticancer agents. We propose a multicriteria recommendation method to identify the most promising anticancer agents against all tested cell lines with an accurate prediction algorithm according to the available input data. A multicriteria decision‐making methodology (MCDM) was used for the solution of the relevant problem in this study. Both the experimental results and MCDM method indicated that 5,7‐dibromo‐8‐hydroxyquinoline (2) and 6,8‐dibromo‐1,2,3,4‐tetrahydroquinoline (6) are the most promising anticancer agents against the HeLa, HT29, and C6 cell lines.
The association between anger experiences and expression and veteran suicidal thoughts in intimate couple relationships
Authors: Wilks Chelsey R. , Khalifian Chandra E. , Glynn Shirley M. , Morland Leslie A. 
Published: May 2020

AbstractObjectiveAnger has been identified as a risk factor for suicide in veterans with posttraumatic stress disorder (PTSD), theoretically because it erodes social support networks. In romantic relationships, the transactional properties of anger on suicidal ideation (SI) have not been explored.MethodsVeterans (n = 138) and their significant others (S‐Os; total N = 276) completed assessments on anger and SI as part of a baseline assessment in a treatment outcome study for veterans with PTSD and their S‐Os. Actor Partner Interdependence Moderation Model (APIMoM) with Multilevel Modeling (MLM) was conducted.ResultsVeteran and S‐Os verbal and anger expression were associated with veteran's SI, while S‐Os' physical anger expression was associated with veteran's SI. S‐Os' feeling angry was associated with veteran's SI. Veteran angry temperament was associated with veteran SI.DiscussionAnger should be considered an assessment and treatment target in veterans with PTSD with SI and their S‐Os.
GYG1: A distal myopathy with polyglucosan bodies
Authors: Nicolau Stefan , Tracy Jennifer A. , Pisapia David J. , Tanji Kurenai , Milone Margherita 
Published: May 2020

AbstractMutations in glycogenin‐1 (GYG1) cause an adult‐onset polyglucosan body myopathy. We report here a patient presenting with late‐onset distal myopathy. We wish to highlight this rare clinical phenotype of GYG1‐related myopathy and the histological clues leading to its diagnosis.
Hypoalbuminemia predicts the outcome of COVID‐19 independent of age and co‐morbidity
Authors: Huang Jiaofeng , Cheng Aiguo , Kumar Rahul , Fang Yingying , Chen Gongping , Zhu Yueyong , Lin Su 
Published: May 2020

AbstractThe coronavirus disease 2019 (COVID‐19) has evolved into a pandemic rapidly. Most of the literature show that the elevated liver enzymes in COVID‐19 are of little clinical significance. Lower albumin level is seen in severe COVID‐19 and is not parallel to the changes in alanine aminotransferase and aspartate aminotransferase levels. We aimed to explore the impact of hypoalbuminemia in COVID‐19. This retrospective cohort study included adult patients with confirmed COVID‐19. The relationship between hypoalbuminemia and death was studied using binary logistic analysis. A total of 299 adult patients were included, 160 (53.5%) were males and the average age was 53.4 ± 16.7 years. The median time from the onset of illness to admission was 3 days (interquartile ranges, 2‐5). Approximately one‐third of the patients had comorbidities. Hypoalbuminemia (<35 g/L) was found in 106 (35.5%) patients. The difference in albumin was considerable between survivors and non‐survivors (37.6 ± 6.2 vs 30.5 ± 4.0, P < .001). Serum albumin level was inversely correlated to white blood cell (r = –.149, P = .01) and neutrophil to lymphocyte ratio (r = −.298, P < .001). Multivariate analysis showed the presence of comorbidities (OR, 6.816; 95% CI, 1.361‐34.133), lymphopenia (OR, 13.130; 95% CI, 1.632‐105.658) and hypoalbuminemia (OR, 6.394; 95% CI, 1.315‐31.092) were independent predictive factors for mortality. In conclusion, hypoalbuminemia is associated with the outcome of COVID‐19. The potential therapeutic value of albumin infusion in COVID‐19 should be further explored at the earliest.
Varicella‐zoster virus infection in the pediatric population with acute lymphoblastic leukemia in Poland
Authors: Zawitkowska Joanna , Lejman Monika , Szmydki‐Baran Anna , Zaucha‐Prażmo Agnieszka , Czyżewski Krzysztof , Dziedzic Magdalena , Zalas‐Więcek Patrycja , Gryniewicz–Kwiatkowska Olga , Czajńska‐Deptuła Aneta , Gietka Agnieszka , Semczuk Katarzyna , Hutnik Łukasz , Chełmecka‐Wiktorczyk Liliana , Żak Iwona , Frączkiewicz Jowita , Salamonowicz Małgorzata , Tomaszewska Renata , Zając‐Spychała Olga , Irga‐Jaworska Ninela , Bień Ewa , Płonowski Marcin , Bartnik Magdalena , Ociepa Tomasz , Pierlejewski Filip , Machnik Katarzyna , Gamrot‐Pyka Zuzanna , Badowska Wanda , Brzeski Tomasz , Urbanek‐Dądela Agnieszka , Stolpa Weronika , Mizia‐Malarz Agnieszka , Skowron‐Kandzia Katarzyna , Musiał Jakub , Styczyński Jan 
Published: May 2020

AbstractVaricella‐zoster virus (VZV) infection in pediatric hemato‐oncology patients can be a therapeutic problem when children are exposed to immunosuppression. The aim of this study is to evaluate the incidence of VZV infection, antiviral therapy and outcome in children with ALL treated in polish hemato‐oncological centers between 2012 and 2019 years. This study included medical records of 1874 patients, aged 1 to 18 years, with newly diagnosed acute lymphoblastic leukemia. During chemotherapy, 406 children out of 1874 (21.6%) experienced viral infections. The incidence of VZV infection in the whole group children with ALL was 1.8%. Among them, 34 (8.4%) patients were diagnosed with VZV infection. Thirty‐five episodes of viral infections were identified. The median time of VCV therapy was 12 days. Herpes zoster infection occurred in 24 (70.6%) children, and varicella in 10 (29.4%) ones. The average time from the start of chemotherapy to the appearance of herpes zoster was 7.26 ± 4.05 months. VZV infection occurred mainly during the maintenance therapy, the reinduction and induction phases. There was no correlation between steroid dosage or type and subsequent zoster. The total lymphocyte count of these patients on the first day of zoster was reduced. No serious complications were observed due to this infection. All patients survived. In conclusion, a low incidence of VZV infection was observed among pediatric patients with ALL in Poland. This analysis indicates that currently used therapeutic methods are effective in children with cancer and VZV infection. The main focus should be on the prevention of delayed chemotherapy.
Characterization of snowfall events in the northern Iberian Peninsula and the synoptic classification of heavy episodes (1988–2018)
Authors: de Pablo Dávila Fernando , Rivas Soriano Luís J. , Mora García Manuel , González‐Zamora Ángel 
Published: May 2020

AbstractHistoric snowfall events in the northern Iberian Peninsula recorded between 1988 and 2018 are presented and analysed. This study makes use of data collected over a course of 31 years from 105 observation stations. These weather reports describe the temporal and spatial characteristics of five Spanish provinces facing the Cantabrian Sea. The average number of snow events observed per year (as recorded by all 105 stations) was 133, where a maximum of 421 snow events was recorded in 2010 and a minimum of 24 events were recorded in 2002. In addition, the monthly distribution of snow events per day had a maximum of 630 events, (February), with a mean monthly value of 170 snow events. Other features like the distribution of snow events depending on the altitude of each province studied and the corresponding spatial patterns are also shown. Furthermore, the circulation patterns responsible for heavy snowfall in the region were also examined. To carry out this study, we considered the daily patterns at 1,200 UTC of the geopotential height at 500 and 850 hPa pressure levels and sea‐level pressure and temperature at 500 and 850 hPa, respectively. The synoptic situations were classified based on a principal component analysis coupled with a K‐means clustering, and four groups associated with heavy snowfall events were subsequently identified. The analysis of the daily synoptic patterns showed that a trough was present over the Iberian Peninsula, or close by, and a low appeared over the Mediterranean Sea or Central Europe. The low‐level flow was from the north (N) or northeast (NE) in ~85% of the cases and the temperature at 850 hPa pressure level was lower than −3°C in ~70% of the cases.
Moment arm function dictates patella sagittal height anatomy: Rabbit epiphysiodesis model alters limb length ratios and subsequent patellofemoral anatomical development
Authors: Dan Michael J. , Parr William C. H. , Crowley James D. , Oliver Rema A. , Kai Lun Kimberley , Lovric Vedran , Cross Mervyn , Broe David , Walsh William R. 
Published: May 2020

AbstractPatellofemoral anatomical dysplasia is associated with patellofemoral instability and pain. The closure of the knee physis occurs at the same age as the peak incidence of patellofemoral dislocation. This study determined the effect on the patellofemoral anatomical development in a rabbit epiphysiodesis model. Twenty‐four skeletally immature New Zealand White rabbits were divided into three groups (a) distal femur epiphysiodesis (FE) (b) proximal tibia epiphysiodesis (TE) (c) control; no epiphysiodesis (C) performed at 6 weeks of age. The primary endpoint was shape analysis using three‐dimensional reconstructions of micro‐computed tomographys (CTs) performed at 30 weeks of age. The limb length ratios (femur:tibia) were significantly different for both FE (mean 0.72, SD 0.0381, P < .001) and TE (mean 0.91, SD 0.0383, P < .001) treatment groups compared to control (mean 0.81, SD 0.0073). Patella height, as measured from the most distal point of the patella to the tibial joint surface (modified Caton‐Deschamps measurement), was lower (baja) in the FE and higher (alta) for the TE, compared with the control group. Our findings suggest femoral and tibial shortening can influence the development of the patellofemoral joint, which may be dictated by moment arm function and is potentially responsible for the etiology of patella alta. Future studies are warranted to explore this association further with the view for the development of treatment options for patella alta in human patients.
Higher ROS scavenging ability and plasma membrane H+‐ATPase activity are associated with potassium retention in drought tolerant tea plants
Authors: Zhang Xianchen , Wu Honghong , Chen Jingguang , Chen Linmu , Chang Na , Ge Gaofei , Wan Xiaochun 
Published: May 2020

AbstractDrought is one of the main limiting factors resulting in the reduction of yield and quality of tea production. Our previous studies indicated that K+ retention was a key factor associated with alleviating drought‐induced damage in tea plants. However, the underlying mechanisms are still unclear. In the present study, drought tolerant tea plant (variety Zhongcha108) exhibited higher plasma membrane (PM) H+‐ATPase activity and lower negative membrane potential compared with the drought sensitive tea plant (variety Ruanzhiwulong). In addition to superior mesophyll K+ retention ability and higher PM H+‐ATPase activity, the drought tolerant tea plant exhibited lower accumulation of reactive oxygen species (ROS) than the sensitive one. Moreover, exogenous supply of Na3VO4 (plasma membrane H+‐ATPase inhibitor) and H2O2 (mimicking apoplastic ROS) resulted in a significantly higher K+ efflux in the mesophyll of the drought sensitive tea plant than the non‐treated one. Taken together, the higher ROS scavenging ability and plasma membrane H+‐ATPase activity were major factors contributing to the higher K+ retention in drought tolerant tea plants.
Safety assays and nutritional values of mycoprotein produced by Fusarium venenatum IR372C from date waste as substrate
Authors: Hashempour‐Baltork Fataneh , Hosseini Seyede Marzieh , Assarehzadegan Mohammad‐Ali , Khosravi‐Darani Kianoush , Hosseini Hedayat 
Published: May 2020

AbstractBACKGROUNDNutritional and environmental benefits of mycoprotein verify its beneficial role on the health of humankind in the next decades. Agro‐industrial wastes can be used as cheap substrates to decrease the total cost of product. However, fungi may produce toxins or lead to allergic reactions in consumers. Therefore, the study of the safety and nutritional aspects of this product are very important.RESULTSFusarium venenatum IR372C was cultured on date wastes and ammonium salts in submerge fermentation. The safety and nutritional issues of produced mycoprotein were investigated including allergy tests and analyses of toxins, as well as existence of toxin genes, and content of heavy metals, metals, amino acids and fatty acids. The results showed that fumonisin genes in F. venenatum IR372C remain without any gene expression during 1 week fermentation. Zearalenone and deoxynivalenol cannot be detected in the fermentation medium after 3 weeks. Prick tests on 30 volunteers demonstrated no sensitivities to mycoprotein. The content of lead was 658 μg kg−1 as the highest heavy metal followed by arsenic, cadmium and mercury at 161, 30.57 and 0 μg kg−1, respectively. Produced mycoprotein includes essential amino acids at appropriate contents and the ratio of unsaturated to saturated fatty acid was nearly 2:1. Also, calcium, iron, magnesium and zinc were found in mycoprotein, which could have health beneficial impacts on consumers.CONCLUSIONThis study has provided information on safety aspects of mycoprotein production by F. venentaum IR372C from date wastes. However, further studies with focus on long‐term clinical benefits of diets containing mycoprotein are necessary. © 2020 Society of Chemical Industry
Influence of caramel and molasses addition on acrylamide and 5‐hydroxylmethylfurfural formation and sensory characteristics of non‐centrifugal cane sugar during manufacturing
Authors: Sung Wen‐Chieh , Chi Ming‐Hsuan , Chiou Tai‐Ying , Lin Shyh‐Hsiang , Lee Wei‐Ju 
Published: May 2020

AbstractBACKGROUNDThe aims of this study are to (i) evaluate the effects of color enhancers, caramel (C) and molasses (M), on acrylamide and 5‐hydroxylmethylfurfural (HMF) formation in non‐centrifugal cane sugar (NCS) and to (ii) perform nine‐point hedonic scale and evaluation of sensory attributes, encompassing the appearance, flavor, texture and aftertaste, by 71 consumers on NCS, NCS_C, and NCS products made with a blend of molasses and sugar (NCS_MS) and steam processing (NCS_S).RESULTSWith the addition of molasses and caramel at the maximum allowable level of 5 g kg−1 in sugarcane juice, significantly greater acrylamide or HMF did not accumulate in NCS_C and NCS_M during the thermal manufacturing process, while color values of NCS_C significantly changed (P < 0.05). The increases in acrylamide and HMF contents were influenced by pH because they were produced by the Maillard reaction. Hedonic responses showed that NCS_MS was rated with the highest score for overall acceptance, whereas NCS_S, with the lowest content of acrylamide, exhibited the lowest score for every attribute. In addition, the appearance acceptance score of NCS_C was significantly higher than that of NCS (P < 0.05). Significant differences were also found between NCS and NCS_C in the frequency of 9 of 16 items with which consumers selected to characterize the appearance in a check‐all‐that‐apply questionnaire (P < 0.05).CONCLUSIONSThe association between hedonic evaluations and sensory profiles in visual attributes of NCS_C indicated that caramel could be a promising addition in Maillard reaction‐mitigated NCS products to improve consumer preferences through color strengthening without safety concerns. © 2020 Society of Chemical Industry
BV‐packing integral in Rn
Authors: Kuncová Kristýna 
Published: May 2020

AbstractWe introduce new integrals (called packing and integrals) which combine advantages of integrals developed by Pfeffer [17], Malý [12], Kuncová and Malý [10] and Malý and Pfeffer [13]. We prove Gauss–Green theorem in generality of the new integrals and provide comparison with the integrals mentioned above and some others (like by Ball and Preiss [2]).