bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early relapse rate determines further relapse risk: results of a 5-year follow-up study on pediatric CFH-Ab HUS
Authors: Hofer Johannes , Riedl Khursigara Magdalena , Perl Markus , Giner Thomas , Rosales Alejandra , Cortina Gerard , Waldegger Siegfied , Jungraithmayr Therese , Würzner Reinhard 
Published: October 2020

Abstract
Background
The complement factor H antibody (CFH-Ab)–associated hemolytic uremic syndrome (HUS) forms a distinct subgroup within the complement-mediated HUS disease spectrum. The autoimmune nature of this HUS subgroup implies the potential benefit of a targeted immunosuppressive therapy. Data on long-term outcome are scarce.

Methods
This observational study evaluates the clinical outcome of 19 pediatric CFH-Ab HUS patients from disease onset until their 5-year follow-up.

Results
All but one relapse occurred during the first 2 years, and patients who had no relapse within the first 6 months were relapse-free until the end of the observation period. Kidney function at disease onset determines long-term kidney function: all individuals with normal kidney function at disease onset had normal kidney function after 5 years, and all patients with reduced kidney function at onset had impaired kidney function at the last follow-up. Level of CFH-Ab titer at disease onset was not correlated with a higher risk of recurrences or worse long-term outcome after 5 years. Resolution of CFH-Ab titers after 5 years was common.

Conclusions
CFH-Ab HUS patients have a varied overall long-term course. Early relapses are common, making close surveillance during the first years essential, regardless of the initial CFH-Ab titer.
Uferfiltration – Stand der Technik und neue Herausforderungen
Authors: Handl Sebastian , Schmoller Christoph , Perfler Reinhard 
Published: October 2020

ZusammenfassungDie Uferfiltration ist eine naturnahe Methode der Trinkwassergewinnung, bei der Oberflächenwasser durch die Förderung von ufernahem Grundwasser in den Untergrund infiltriert und dabei natürlich gereinigt wird. Während der Fließstrecke vom Oberflächenwasser bis hin zum Brunnen finden verschiedene physikalische, chemische und mikrobiologische Prozesse statt. Neben der Aufenthaltszeit des Wassers im Untergrund haben die Redoxbedingungen den größten Einfluss auf wesentliche Entfernungsvorgänge wie biologischen Abbau und Sorption. Neben den noch unspezifischen Konsequenzen infolge des Klimawandels, stellen heute insbesondere „neu aufkommende“ Spurenstoffe, die teilweise noch unzureichend erforscht und in toxikologischer Hinsicht schwer einschätzbar sind, das zentrale Problem dar. Die Uferfiltration stellt im Vergleich zu alternativen Aufbereitungsverfahren von Wasser aus Oberflächengewässern eine effektive Methode insbesondere auch zur Reduktion der Kosten dar.
Yoga effectively reduces fatigue and symptoms of depression in patients with different types of cancer
Authors: Zetzl Teresa , Renner Agnes , Pittig Andre , Jentschke Elisabeth , Roch Carmen , van Oorschot Birgitt 
Published: October 2020

Abstract
Purpose
Examine the effects of an 8-week yoga therapy on fatigue in patients with different types of cancer.

Methods
A total of 173 cancer patients suffering from mild to severe fatigue were randomly allocated to yoga intervention (n = 84) (IG) versus waitlist control group (CG) (n = 88). Yoga therapy consisted of eight weekly sessions with 60 min each. The primary outcome was self-reported fatigue symptoms. Secondary outcomes were symptoms of depression and quality of life (QoL). Data were assessed using questionnaires before (T0) and after yoga therapy for IG versus waiting period for CG (T1).

Results
A stronger reduction of general fatigue (P = .033), physical fatigue (P = .048), and depression (P < .001) as well as a stronger increase in QoL (P = .002) was found for patients who attended 7 or 8 sessions compared with controls. Within the yoga group, both higher attendance rate and lower T0-fatigue were significant predictors of lower T1-fatigue (P ≤ .001). Exploratory results revealed that women with breast cancer report a higher reduction of fatigue than women with other types of cancer (P = .016) after yoga therapy.

Conclusion
The findings support the assumption that yoga therapy is useful to reduce cancer-related fatigue, especially for the physical aspects of fatigue. Women with breast cancer seem to benefit most, and higher attendance rate results in greater reduction of fatigue.

Trial registration
German Clinical Trials Register DRKS00016034
Retrospective analysis of complications in 190 mandibular resections and simultaneous reconstructions with free fibula flap, iliac crest flap or reconstruction plate: a comparative single centre study
Authors: Ritschl Lucas M. , Mücke Thomas , Hart Diandra , Unterhuber Tobias , Kehl Victoria , Wolff Klaus-Dietrich , Fichter Andreas M. 
Published: October 2020

Abstract
Objectives
The purpose of this study was to evaluate the incidence of complications following mandibular reconstruction and to analyse possible contributing factors.

Materials and methods
Clinical data and computed tomography scans of all patients who needed a mandibular reconstruction with a reconstruction plate, free fibula flap (FFF) or iliac crest (DCIA) flap between August 2010 and August 2015 were retrospectively analysed.

Results
One hundred and ninety patients were enrolled, encompassing 77 reconstructions with reconstruction plate, 89 reconstructions with FFF and 24 reconstructions with DCIA flaps. Cutaneous perforation was most frequently detected in the plate subgroup within the early interval and overall (each p = 0.004). Low body mass index (BMI) and total radiation dosage were the most relevant risk factors for the development of analysed complications.

Conclusions
Microvascular bone flaps have overall less skin perforation than reconstruction plates. BMI and expected total radiation dosage have to be respected in choice of reconstructive technique.

Clinical relevance
A treatment algorithm for mandibular reconstructions on the basis of our results is presented.
Takayasu arteritis: a cohort of Italian patients and recent pathogenetic and therapeutic advances
Authors: Dammacco Franco , Cirulli Anna , Simeone Annalisa , Leone Patrizia , Pulli Raffaele , Angiletta Domenico , Rubini Giuseppe , Di Palo Alessandra , Vacca Angelo , Dammacco Rosanna 
Published: October 2020

AbstractTakayasu arteritis (TAK) is a rare granulomatous vasculitis of unknown etiology that mainly affects the aorta and its major branches. The aim is to describe the clinical features, diagnostic procedures, pathogenesis, and management of TAK in a longitudinal cohort of patients recruited within a single region of southern Italy. The cohort included 43 patients who were diagnosed with TAK and followed up according to a standard protocol, in a collaboration between four university tertiary referral centers and a regional hospital. Clinical and imaging classification criteria were those established by the American College of Rheumatology. Thirty-five patients (81.4%) were female, and the mean age at disease onset was 32.6 (range 16–54) years. Angiographic assessment of the vascular involvement allowed disease classification in five different types. Clinical features ranged from constitutional symptoms in the early inflammatory stage of the disease to cardiovascular ischemic symptoms in the late, chronic stage. Noninvasive imaging techniques were employed to assess the extent and severity of the arterial wall damage and to monitor the clinical course and response to therapy. Medical treatment, based on pathogenetic insights into the roles of humoral and cell-mediated immune mechanisms, included glucocorticoids mostly combined with steroid-sparing immunosuppressive agents and, in patients with relapsing/refractory disease, biologic drugs. Significant clinical and angiographic differences have been detected in TAK patients from different geographic areas. Patients with life-threatening cardiovascular and neurologic manifestations as well as sight-threatening ophthalmologic signs and symptoms should be promptly diagnosed, properly treated, and closely followed up to avoid potentially severe consequences.
The invasive Opuntia ficus-indica homogenizes native plant species compositions in the highlands of Eritrea
Authors: Tesfay Yohannes B. , Kreyling Juergen 
Published: October 2020

AbstractInvasion by exotic species is recognized as one of the major threats to biodiversity. The effects of invasion byOpuntia ficus-indica(Cactaceae) on the species diversity, richness and composition of invaded communities were studied at three sites in the highlands of Eritrea, East Africa. This paper investigates whether the presence ofO. ficus-indicacauses a negative effect on the native biodiversity in a region rarely studied so far. The vegetation in invaded and uninvaded plots with similar habitat conditions was sampled and differences in the species composition, diversity and richness were compared between the plots. The overall plant species composition differed significantly with invasion byO. ficus-indica. The invasion byO. ficus-indicaalso led to a significant homogenization of community compositions. The species richness and Shannon diversity index did not differ significantly between the invaded and uninvaded plots. Nevertheless, we still detected species with significantly lower occurrence in the invaded plots (Psiadia punctulata), but also species which preferred invaded plots (Plectranthus hadiensis). We conclude thatO. ficus-indicaexerts a negligible effect on the species diversity and richness but that it affects species composition and that there are species which suffer due to its presence. Due to the continuous pressure of the invasion byO. ficus-indicaon the species composition and dry climates, further homogenization in the native species diversity is to be expected in the future for the highlands of Eritrea.
Grappling with uncertainties in physical climate impact projections of water resources
Authors: Dankers Rutger , Kundzewicz Zbigniew W. 
Published: October 2020

AbstractThis paper reviews the sources of uncertainty in physical climate impact assessments. It draws on examples from related fields such as climate modelling and numerical weather prediction in discussing how to interpret the results of multi-model ensembles and the role of model evaluation. Using large-scale, multi-model simulations of hydrological extremes as an example, we demonstrate how large uncertainty at the local scale does not preclude more robust conclusions at the global scale. Finally, some recommendations are made: climate impact studies should be clear about the questions they want to address, transparent about the uncertainties involved, and honest about the assumptions being made.
Blended Learning Adoption and Implementation in Higher Education: A Theoretical and Systematic Review
Authors: Anthony Bokolo , Kamaludin Adzhar , Romli Awanis , Raffei Anis Farihan Mat , Phon Danakorn Nincarean A. L. Eh , Abdullah Aziman , Ming Gan Leong 
Published: October 2020

AbstractTechnological innovations such as blended learning (BL) are rapidly changing teaching and learning in higher education, where BL integrates face to face teaching with web based learning. Thus, as polices related to BL increases, it is required to explore the theoretical foundation of BL studies and how BL were adopted and implemented in relation to students, lecturers and administration. However, only fewer studies have focused on exploring the constructs and factors related to BL adoption by considering the students, lecturers and administration concurrently. Likewise, prior research neglects to explore what practices are involved for BL implementation. Accordingly, this study systematically reviews, synthesizes, and provides meta-analysis of 94 BL research articles published from 2004 to 2020 to present the theoretical foundation of BL adoption and implementation in higher education. The main findings of this study present the constructs and factors that influence students, lecturers and administration towards adopting BL in higher education. Moreover, findings suggest that the BL practices to be implemented comprises of face-to-face, activities, information, resources, assessment, and feedback for students and technology, pedagogy, content, and knowledge for lecturers. Besides, the review reveals that the ad hoc, technology acceptance model, information system success model, the unified theory of acceptance and use of technology, and lastly diffusion of innovations theories are the mostly employed theories employed by prior studies to explore BL adoption. Findings from this study has implications for student, lecturers and administrators by providing insights into the theoretical foundation of BL adoption and implementation in higher education.
Fungal Volatiles as Olfactory Cues for Female Fungus Gnat, Lycoriella ingenua in the Avoidance of Mycelia Colonized Compost
Authors: Kecskeméti Sándor , Szelényi Magdolna Olívia , Erdei Anna Laura , Geösel András , Fail József , Molnár Béla Péter 
Published: October 2020

AbstractThe chemical signatures emitted by fungal substrates are key components for mycophagous insects in the search for food source or for suitable oviposition sites. These volatiles are usually emitted by the fruiting bodies and mycelia. The volatiles attract fungivorous insects, like flowers attract pollinators; certain flowers mimic the shape of mushroom fruiting bodies and even produce a typical mushroom odor to exploit on fungus-insect mutualism. There are numerous insects which are mycophagous or eat fungi additionally, but only a few are considered a threat in agriculture. Lycoriella ingenua is one of the most serious pests in mushroom cultivation worldwide. Here we attempt to examine the role of environmental volatiles upon behavioral oviposition preference. In two-choice bioassays, fungus gnats preferred uncolonized compost compared to colonized compost but preferred colonized compost against nothing. However, when colonized compost was paired against distilled water, no significant choice was observed. The comparison of fresh casing material and mycelium colonized casing material resulted in no significant preference. From colonized compost headspace, three antennally active volatiles were isolated by gas chromatography coupled with electroantennography and subsequently identified with gas chromatography coupled mass spectrometry as 1-hepten-3-ol, 3-octanone and 1-octen-3-ol. In behavioral assays the addition of said synthetic volatiles to uncolonized compost separately and in combination to mimic colonized compost resulted in avoidance. We thus partially elucidate the role of fungal volatiles in the habitat seeking behavior of Lycoriella ingenua.
Open data governance: civic hacking movement, topics and opinions in digital space
Authors: Maretti Mara , Russo Vanessa , del Gobbo Emiliano 
Published: October 2020

AbstractThe expression ‘open data’ relates to a system of informative and freely accessible databases that public administrations make generally available online in order to develop an informative network between institutions, enterprises and citizens. On this topic, using the semantic network analysis method, the research aims to investigate the communication structure and the governance of open data in the Twitter conversational environment. In particular, the research questions are: (1) Who are the main actors in the Italian open data infrastructure? (2) What are the main conversation topics online? (3) What are the pros and cons of the development and use (reuse) of open data in Italy? To answer these questions, we went through three research phases: (1) analysing the communication network, we found who are the main influencers; (2) once we found who were the main actors, we analysed the online content in the Twittersphere to detect the semantic areas; (3) then, through an online focus group with the main open data influencers, we explored the characteristics of Italian open data governance. Through the research, it has been shown that: (1) there is an Italian open data governance strategy; (2) the Italian civic hacker community plays an important role as an influencer; but (3) there are weaknesses in governance and in practical reuse.
A multi-center psychometric evaluation of the Severity Indices of Personality Problems 118 (SIPP-118): Do we really need all those facets?
Authors: Paap Muirne C. S. , Hummelen Benjamin , Braeken Johan , Arnevik Espen A. , Walderhaug Espen , Wilberg Theresa , Berghuis Han , Hutsebaut Joost , Pedersen Geir 
Published: October 2020

Abstract
Purpose
The Severity Indices of Personality Problems 118 (SIPP-118) is a self-report questionnaire that aims to measure core components of (mal)adaptive personality functioning that can change over time. In this study, we aimed to assess the facet strength of the 16 facets across three large clinical samples.

Methods
Data from Norwegian and Dutch psychiatric patients were analyzed in this international multi-center study (N1 = 2814, N2 = 4751, N3 = 2217). Bi-factor modeling was used to assess to what degree the SIPP items tap into an overall general factor. The incremental value (distinctiveness) of the facets was studied using proportional reduction in mean squared error (PRMSE) based statistics.

Results
The estimated model showed adequate fit. The explained common variance (ECV) attributable to the general factor equaled 50% for all three samples. All but two facets (stable self-image and frustration tolerance) showed sufficient levels of distinctiveness. The findings were observed to be comparable across the three samples.

Conclusion
Our findings showed that the general factor was relatively weak, and the facets had a clear incremental value.
Male and female entrepreneurs’ employment growth ambitions: the contingent role of regulatory efficiency
Authors: Darnihamedani Pourya , Terjesen Siri 
Published: October 2020

AbstractEntrepreneurs start and grow their ventures in a widely varying set of institutional contexts. One differentiator is a country’s regulatory efficiency which encompasses the freedom to start and to run a business without excessive government interventions around registering, hiring, and firing employees, and price controls on currency. The efficiency of regulations varies substantially among countries and imposes additional costs and risks on entrepreneurs’ activities. We integrate insights from institutional theory and recent literature on gender and entrepreneurship to better understand how a country’s regulatory efficiency affects male and female entrepreneurs’ employment growth ambitions. We explore three aspects of regulatory efficiency: business freedom (e.g., to start, operate, and close a venture), labor freedom (e.g., laws around minimum wage, layoffs, severance), and monetary freedom (e.g., price stability) using data from over 47,000 entrepreneurs in 68 countries. We find that entrepreneurs’ growth ambitions are higher in countries with more efficient regulations, particularly those countries characterized by fewer labor law restrictions and greater monetary freedoms. These findings are further exacerbated by gender by such that, relative to their female counterparts, male entrepreneurs have significantly greater venture growth ambitions. Our paper contributes to the discussion on how formal institutions influence women and men entrepreneurs in distinct ways.
Biomarkers of iron metabolism in chronic kidney disease
Authors: Tomasz Glogowski , Ewa Wojtaszek , Jolanta Malyszko 
Published: October 2020

AbstractIron is the most abundant transition metal in the human body and an essential element required for growth and survival. Our understanding of the molecular control of iron metabolism has increased dramatically over the past 20 years due to the discovery of hepcidin, which regulates the uptake of dietary iron and its mobilization from macrophages and hepatic stores. Anemia and iron deficiency are common in chronic kidney disease. The pathogenesis of anemia of chronic kidney disease is multifactorial. Correction of anemia requires two main treatment strategies: increased stimulation of erythropoiesis, and maintenance of an adequate iron supply to the bone marrow. However, there are still many uncertainties in regard to iron metabolism in patients with chronic kidney disease and in renal replacement therapy. The aim of this review was to summarize the current knowledge on iron metabolism in this population, including new biomarkers of iron status. There is an area of uncertainty regarding diagnostic utility of both erythroferrone (ERFE) and hepcidin in end-stage renal disease (ESRD) patients. Higher concentration of hepcidin in oligoanuric patients may reflect decreased renal clearance. Furthermore, the hepcidin-lowering effect of ERFE in ESRD patients treated with erythropoiesis-stimulating agents (ESAs) may be blunted by underlying inflammation and concomitant iron treatment. Thus, future studies should validate the use of ERFE as a biomarker of erythropoiesis and predictor of response to iron and ESA therapy in dialysis-dependent patients.
Impact of Force Function Formulations on the Numerical Simulation of Centre-Based Models
Authors: Mathias Sonja , Coulier Adrien , Bouchnita Anass , Hellander Andreas 
Published: October 2020

AbstractCentre-based or cell-centre models are a framework for the computational study of multicellular systems with widespread use in cancer modelling and computational developmental biology. At the core of these models are the numerical method used to update cell positions and the force functions that encode the pairwise mechanical interactions of cells. For the latter, there are multiple choices that could potentially affect both the biological behaviour captured, and the robustness and efficiency of simulation. For example, available open-source software implementations of centre-based models rely on different force functions for their default behaviour and it is not straightforward for a modeller to know if these are interchangeable. Our study addresses this problem and contributes to the understanding of the potential and limitations of three popular force functions from a numerical perspective. We show empirically that choosing the force parameters such that the relaxation time for two cells after cell division is consistent between different force functions results in good agreement of the population radius of a two-dimensional monolayer relaxing mechanically after intense cell proliferation. Furthermore, we report that numerical stability is not sufficient to prevent unphysical cell trajectories following cell division, and consequently, that too large time steps can cause geometrical differences at the population level.