bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunoprecipitation and Mass Spectrometry Define TET1 Interactome During Oligodendrocyte Differentiation
Authors: Zhang Ming , Zhang Kaixiang , Wang Jian , Liu Yuming , Liu Guangxin , Jin Weilin , Wu Shengxi , Zhao Xianghui 
Published: September 2020

Abstract
Ten-eleven translocation (TET) proteins, encoding dioxygenase for DNA hydroxymethylation, are important players in nervous system development and disease. In addition to their proverbial enzymatic role, TET proteins also possess non-enzymatic activity and function in multiple protein-protein interaction networks, which remains largely unknown during oligodendrocyte differentiation. To identify partners of TET1 in the myelinating cells, we performed proteome-wide analysis using co-immunoprecipitation coupled to mass spectrometry (IP-MS) in purified oligodendrocyte precursor cells (OPCs) and mature oligodendrocytes (mOLs), respectively. Following a stringent selection of MS data based on identification reliability and protein enrichment, we identified a core set of 1211 partners that specifically interact with TET1 within OPCs and OLs. Analysis of the biological process and pathways associated with TET1-interacting proteins indicates a significant enrichment of proteins involved in regulation of cellular protein localization, cofactor metabolic process and regulation of catabolic process, et al. We further validated TET1 interactions with selected partners. Overall, this comprehensive analysis of the endogenous TET1 interactome during oligodendrocyte differentiation suggest its novel mechanism in regulating oligodendrocyte homeostasis and provide comprehensive insight into the molecular pathways associated with TET1.
The role of genetic variants in FCGR2A on the risk of rheumatoid arthritis in the Han Chinese population
Authors: Yang Yonghui , Peng Linna , He Chunjuan , Xing Shishi , Li Dandan , Jin Tianbo , Wang Li 
Published: September 2020

Abstract
Background: Rheumatoid arthritis (RA) is the most common inflammatory arthritis and is characterized by irreversible joint damage and deformities, which is largely caused by genetic factors. The aim of this study was to explore the role of FCGR2A polymorphisms with the susceptibility to RA in the Han Chinese cohort.Methods: We enrolled 506 RA patients and 509 healthy controls, with four single nucleotide polymorphisms (SNPs) successfully genotyped using Agena MassARRAY. Genetic models, haplotype analyses were applied to assess the association between FCGR2A polymorphisms and RA. And we evaluated the relative risk by odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression analysis.Results: The results revealed that FCGR2A rs6668534 was significantly related to an increased risk of RA in the overall (OR = 1.24, 95%CI = 1.04 – 1.48, p = 0.014). There was no any association found between the polymorphisms and RA risk at age > 54 years, while the two (rs6671847 and rs1801274) of the four SNPs possibly contributed to the susceptibility to RA at age ≤ 54 years. And the rs6668534 polymorphism conferred the increased susceptibility to RA in the male population. The haplotypes in the FCGR2A gene was significantly associated with the RA risk.Conclusions: Our research have demonstrated that the FCGR2A gene polymorphisms (rs6671847, rs1801274 and rs6668534) were implicated in RA susceptibility in the Han Chinese population.
SARS-COV2 Renal Impairment in Critical Care: A Retrospective Study of 42 Cases - Kid COVID Study
Authors: Barragan Antoine-Marie Molina , Pardo Emmanuel , Galichon Pierre , Hantala Nicolas , Gianinazzi Anne-Charlotte , Darrivere Lucie , Tsai Eileen S. , Garnier Marc , Bonnet Francis , Fieux Fabienne , Verdonk Franck 
Published: September 2020

Abstract
BackgroundThe new coronavirus (SARS-CoV-2) infection leads to 5% to 16% hospitalization in Intensive Care Units (ICU) and is associated with 23% to 75% of kidney impairments, including acute kidney injury (AKI), as a major prognosis factor. The current work aims to characterize the renal impairment associated to SARS-CoV-2 in ICU patients, to evaluate its risk factors and its relationship with morbidity and mortality. Methods Forty-two patients consecutively admitted to the ICU of a university hospital (Paris, France) who tested positive for SARS-CoV-2 between March 25, 2020 and April 29, 2020 were included and classified in categories according to their renal function. Complete renal profiles and their evolution during ICU stay were fully characterized in 34 patients. Factors associated with AKI were identified through univariate analysis.ResultsThirty-two patients (94,1%) met diagnostic criteria for intrinsic renal injury with a mixed pattern of tubular and glomerular injuries within the first week of ICU admission, that lasted upon discharge. During their ICU stay, 24 patients (57.1%) presented AKI which was associated with increased mortality (p = 0.007), hemodynamic failure (p = 0.022), and more altered clearance at hospital discharge (p = 0.001). AKI occurrence was associated with lower pH (p = 0.024), higher PaCO2 (p = 0.027), PEEP (p = 0.027), procalcitonin (p = 0.015), and CRP (p = 0.045) on ICU admission.ConclusionsCritical SARS-CoV-2 is associated with persistent intrinsic renal injury and AKI, which is a risk factor of mortality. Identifying SARS-CoV-2 patients at risk of AKI will help in modifying clinical practice in ICU. Trial registration In accordance with the French law on biomedical research, this study obtained the approval of an Institutional Review Board (“Comité d’Éthique de la Recherche en Anesthésie-Réanimation” under the reference IRB 00010254 ‐ 2020 ‐ 106). Patients were all informed of the possible use of their data in researches as well as their right and terms of objection. Data were collected and integrated anonymously into a secure database in accordance with the French CNIL MR-004 methodology (registration number 20200803123416).
Efficacy of Different Nucleoside Analog Rescue Therapies for Entecavir-Resistant Chronic Hepatitis B Patients
Authors: Shang Jin , Zhou Juan , Liu Huan , Tu You , Ran Jinqiu , Bai Lang , Tang Hong 
Published: September 2020

Abstract
Background: Entecavir (ETV) is recommended as a first-line anti-HBV treatment. However, many chronic hepatitis B patients initiate anti-HBV treatment such as lamivudine and telbivudine with low genetic barriers in China, which leads to compensatory mutations and increases the rate of ETV resistance. The management of ETV resistance in China is an essential clinical issue. Methods: Patients from 2011 to 2017 with nucleos(t)ide analog resistance were screened and 72 patients with ETV resistance were included. These patients received different rescue therapies including an ETV and adefovir (ADV) combination therapy group (n = 25), a tenofovir (TDF) monotherapy group (n = 27), and an ETV and TDF combination therapy group (n = 20). Virologic, biochemical, and serologic responses were compared among the three groups.Results: The rate of ETV resistance increased form 6.04% in 2011 to 15.02% in 2017. Regarding the rates of negative HBV DNA at 48 weeks, no significant differences occurred in the TDF monotherapy and TDF combination groups (74.07% vs 70.00%), while the ETV and ADV group showed the worst virologic response (28.00%). TDF monotherapy and TDF combination therapy showed similar decline of HBV DNA at weeks 12, 24, and 48. There was no significant difference in the rates of HBeAg clearance, ALT normalization, and abnormal renal function between the three groups. Conclusions: TDF monotherapy showed a comparable virologic response to TDF and ETV combination therapy and a better virologic response than ETV and ADV combination therapy. Thus, TDF monotherapy is the preferred rescue therapy for ETV resistance.
Synergistic Effects of Vitamin D and Mindfulness Training in Pain Severity, Pain-Related Disability and Neuropathy-Specific Quality of Life Dimensions in Painful Diabetic Neuropathy: A Randomized Clinical Trial with Placebo-controlled
Authors: nia Roya taghadosi , davoudi mohammadreza , Ahmadi Seyyed Mojtaba , Taheri Amir Abbas 
Published: September 2020

Abstract
Background: This study aimed to examining Synergistic effect of Vitamin D (VD) Supplement and mindfulness on neuropathic pain severity, Pain-Related Disability and Neuropathy-Specific Quality of Life dimensions in painful diabetic neuropathy.Methods: In this randomized controlled trial, totally 225 patients with painful diabetic neuropathy were randomly allocated to five groups: (1) mindfulness and placebo, (2) placebo, (3) mindfulness, (4) VD, and (5) mindfulness and VD. Mindfulness training includes twelves sessions and VD patients received a daily four thousand IU oral dosage (four capsules) with 28,000 IU vitamin D weekly for 12 weeks. Laboratory analyses, Sun exposure time, Vitamin D intake, BMI and Physical activity measured in pre-test and posttest. Pain-Related Disability measured with The Pain Disability Index (PDI). For other outcome variables Neuropathy Specific Quality of Life questionnaire and Neuropathic pain severity scale was utilized.Results: In baseline, measures were not different among the groups. At the end-of-treatment, for outcome variables results showed improvement in all groups except the “placebo” group. About other groups, there was not any difference between VD and mindfulness groups (in and not combined with placebo). However, “VD + mindfulness” has a greater improvement rather than VD and mindfulness groups (P<0.05). Moreover, both protocols have no significant effects on, FBS, BMI and energy intakes (P>0.05).Conclusion: Combining VD and mindfulness can reduce pain severity and pain-related disability, so with these changes patients improve their quality of life.
A comprehensive evaluation of utilization potential of semiterrestrial isopods, Ligia exotica in China: a new aquatic feed?
Authors: Xu Lele , Li Yongqin , Liu Yao , Jiang Xiang , Sun Yulin , Mi Haifeng , Zhao Haiyong , Chen Daohai , Wang Liyun 
Published: September 2020

Abstract
Background: The semiterrestrial isopod, Ligia exotica represents one of the oldest documented species introductions of marine organisms and is known as an intermediate form between marine and strictly terrestrial isopods. In order to explore the practical value for food & feed of Ligia, this study focused on growth rate under laboratory rearing conditions and detailed analysis of the overall nutrient content of the species in comparison to two other aquatic food media (krill and fish meal). Results: Evaluation of the growth rate of juveniles suggests it is a relatively fast-growing species of the Ligiidae family. The essential amino acids content Ligia meal is the lowest but the proportion of flavor amino acids was higher. In particular, the content of taurine was much higher. Amino acid score and chemical score show that the most restricted amino acids of isopod meal are methionine and cysteine. The extremely unbalanced amino acid composition may affect the absorption and utilization by consumers. In terms of fatty acids, the total polyunsaturated fatty acids in isopod is very low. A total of 12 vitamins were examined. The VK1, VE, VB2, VB3, VB5 content of isopod meal were significantly higher than those of krill meal and fish meal. Similarly, most of the 11 mineral elements are the highest in isopod meal. Conclusions: Ligia offers potential as an alternative natural food source especially in aquaculture given the growth rate under culture and the overall nutrient content. But Ligia collected in most of the field would be deemed unfit for human consumption because of the relatively low nutritional value and heavy metal content exceeding the provided standard. Ligia isopods offer some potential to become a crustacean model animal for commercial aquaculture crustaceans, further study is warranted to elucidate its biological characteristics.
Patients’ values and other decisional factors regarding treatment of hypercalcemia of malignancy: A Systematic Review Protocol
Authors: Bassatne Aya , Rahme Maya , Piggott Thomas , Murad Mohammad H , Hneiny Layal , Fuleihan Ghada El-Hajj 
Published: September 2020

Abstract
Background

Hypercalcemia of malignancy is the second most common cause of hypercalcemia and is associated with significant morbidity and mortality. Several treatment options are available including pharmacological therapy with bisphosphonates, denosumab, glucocorticoids, and calcimimetics, as well as conventional therapy with hydration and possibly calcitonin. While guidelines have previously considered treatment effects, no guideline has yet considered a range of contextual factors impacting recommendations for the management.
Objective

The aim of this study is to summarize the available evidence on important decisional factors for the development of guidelines for the treatment of hypercalcemia of malignancy. These include patient’s values and preferences, cost, acceptability, feasibility, and equity.
Methods/Design:

This is a systematic review of observational studies, case series, trials, reviews and qualitative studies involving treatment of adult patients with hypercalcemia of malignancy. We developed and executed two independent search strategies using five databases: Pubmed, Medline (OVID), Embase.com, CINAHL (EBSCO) and Cochrane, and reviewed their combined output. Two reviewers screened titles and abstracts and full texts and will implement data abstraction from relevant studies independently and in duplicate. The outcomes of interest are the decisional factors that influence drug selection, with possible subgroup analyses by drug class or etiology of hypercalcemia of malignancy. We will present the data collected in a narrative and thematic approach.
Discussion

This systematic review will identify important treatment decisional factors, and will assist guidelines panels, physicians and patients to decide on therapeutic options based on the current evidence.
Experimental demonstration of quantum advantage for NP verification
Authors: Centrone Federico , Kumar Niraj , Diamanti Eleni , Kerenidis Iordanis 
Published: September 2020

Abstract
We show the first experimental demonstration of a computational quantum advantage (also referred to as quantum supremacy) with linear optics, by studying the computational task of the verification of an NP-complete problem by a verifier who only gets limited information about the proof. We provide a simple linear optical implementation that can perform this task efficiently (within a few seconds), while we also provide strong evidence that a classical computer would take time greater than the age of the universe (assuming only that classically it takes exponential time to solve an NP-complete problem). The verification of NP-complete problems with limited information brings us a step closer to real-world useful applications, such as server-client quantum computing.
Effects of dietary style on adult enterovirus infection risk factors: a retrospective analysis
Authors: Yu Linghua , Wang Linlin , Yi Huixing , Wu Xiaojun , Sun Fei 
Published: September 2020

Abstract
Background: Gut microbiota serves as a defense against enteric pathogens, whereas dietary intake influences the composition and function of gut microbiota. We aimed to examine the impact of diet on the enteroviral infection in adult patients of hand, foot, and mouth disease (HFMD). Methods: A total of 266 adult patients of HFMD were recruited in this study, with 80 healthyvolunteers served as the control. Swab samples and clinical characteristics were collected. Enteroviral genotype was further assessed by PCR testing. Social-demographic data and dietary records were obtained through follow-up phone calls. Dietary patterns were derived with PCA analysis. Correlation between dietary patterns and clinical characteristics, enterovirus genotype, and HFMD risk factors were evaluated. Results:Three distinct dietary patterns were identified in the participants, which were modern, "atypical south", and "traditional north", respectively. This study found the dietary pattern of adult HFMD significantly differed from that of the controls. A vast majority of controls followed the modern pattern, which was a healthy diet. In contrast, the result showed unhealthy dietary patterns ('atypical south' and 'traditional north') were risk factors for adult HFMD. Besides, the dining place was a leading contributor to the dietary pattern. Our data showed eating at a food stall, or take-out is a risk factor of adult HFMD, whereas eating at the dining room is a protective factor. Conclusions:Our study indicated dietary pattern was associated with the incidence of adult HMFD. Improving the dietetic habit might contribute to HFMD prevention.
Head phantoms for bioelectromagnetic applications: a material study
Authors: Hunold Alexander , Machts René , Haueisen Jens 
Published: September 2020

Abstract
Background Assessments of source reconstruction procedures in electroencephalography and computations of transcranial electrical stimulation profiles require verification and validation with the help of ground truth configurations as implemented by physical head phantoms. Phantoms provide well-defined volume conduction configurations with realistic geometries.We aim to characterize the electrical conductivity of materials for modeling head compartments to establish reproducible and stable physical head phantoms. We analyzed sodium chloride (NaCl) solution, agarose hydrogel, gypsum and reed sticks as surrogate materials for the intracranial volume, scalp, skull and anisotropic conductivity structures. We measured the impedance of all materials when immersed in NaCl solution using a four-point setup. The electrical conductivity values of each material were calculated from the temperature compensated impedances considering the sample geometries. Results We obtained conductivities of 0.332 S/m (0.17 % NaCl solution), 0.0425 S/m and 0.0017 S/m (gypsum with and without NaCl), 0.314 S/m, 0.30 S/m, 0.311 S/m (2 %, 3 %, 4 % agarose). The reed sticks were tested in longitudinal and transversal direction and showed anisotropic conductivity with a ratio of 1:2.8. Conclusion We conclude that the tested materials NaCl solution, gypsum and agarose can serve as stable representation of the three main conductivity compartments of the head, intracranial volume, skull and scalp. An anisotropic conductivity structure such as a piece of white matter can be modeled using tailored reed sticks inside a volume conductor.
Relationships between test positivity rate, total laboratory confirmed cases of malaria, and malaria incidence in high burden settings of Uganda: An ecological analysis
Authors: Okiring Jaffer , Epstein Adrienne , Namuganga Jane F. , Kamya Victor , Sserwanga Asadu , Kapisi James , Ebong Chris , Kigozi Simon P. , Mpimbaza Arthur , Wanzira Humphrey , Briggs Jessica , Kamya Moses R. , Nankabirwa Joaniter I. , Dorsey Grant 
Published: September 2020

Abstract
Background: Malaria surveillance is critical for monitoring changes in malaria morbidity over time. National Malaria Control Programs often rely on surrogate measures of malaria incidence, including the test positivity rate (TPR) and total laboratory confirmed cases of malaria (TCM), to monitor trends in malaria morbidity. However, there are limited data on the accuracy of TPR and TCM for predicting temporal changes in malaria incidence, especially in high burden settings.Methods: This study leveraged data from 5 malaria reference centers (MRCs) located in high burden settings over a 15-month period from November 2018 through January 2020 as part of an enhanced health facility-based surveillance system established in Uganda. Individual level data were collected from all outpatients including demographics, laboratory test results, and village of residence. Estimates of malaria incidence were derived from catchment areas around the MRCs. Temporal relationships between monthly aggregate measures of TPR and TCM relative to estimates of malaria incidence were examined using linear and exponential regression models.Results: A total of 149,739 outpatient visits to the 5 MRCs were recorded. Overall, malaria was suspected in 73.4% of visits, 99.1% of patients with suspected malaria received a diagnostic test, and 69.7% of those tested for malaria were positive. Temporal correlations between monthly measures of TPR and malaria incidence using linear and exponential regression models were relatively poor, with small changes in TPR frequently associated with large changes in malaria incidence. Linear regression models of temporal changes in TCM provided the most parsimonious and accurate predictor of changes in malaria incidence, with adjusted R2 values ranging from 0.81 to 0.98 across the 5 MRCs. However, the slope of the regression lines indicating the change in malaria incidence per unit change in TCM varied from 0.57 to 2.13 across the 5 MRCs, and when combining data across all 5 sites, the R2 value reduced to 0.38.Conclusions: In high malaria burden areas of Uganda, site-specific temporal changes in TCM had a strong linear relationship with malaria incidence and were a more useful metric than TPR. However, caution should be taken when comparing changes in TCM across sites.
Selective Recovery of Precious Metals through Photocatalysis
Authors: Chen Yao , Xu Mengjiao , Wen Jieya , Wan Yu , Zhao Qingfei , Cao Xia , Ding Yong , Wang Zhong , Li Hexing , Bian Zhenfeng 
Published: September 2020

Abstract
Precious metals such as gold and platinum are valued materials for a variety of important applications, but their scarcity poses a risk of supply interruption. However, the dissolution and recovery of precious metals using the current methods are limited by associated serious environmental pollution and high energy consumption. Here, we show a photocatalytic process that allows one to selective retrieve 7 kinds of precious metal elements (Ag, Au, Pd, Pt, Ru, Rh and Ir) (with dissolution efficiency of 99%) from waste circuit boards, ternary automotive catalysts and even ores. Precious metals is recovered with high purity (≥98%) through a simple reductive method. The whole process only needs light and catalyst without strong acid, strong base and highly toxic cyanide. It has an environmentally friendly, scalable and efficient way, in which the catalyst has been recycled more than 100 times under normal temperature and pressure without performance degradation. It has successfully realized the scale of dissolution from grams to kilograms, and it is expected to realize large-scale recovery of precious metals in industrial application. This general approach provides an unprecedent technology for recycling resources on earth.
Investigation on Ti-6Al-4V Alloy Surface Characteristics Using Nano Grinding Wheel by Response Surface Methodology (RSM) with Artificial Neural Networking (ANN)
Authors: Stephen Deborah Serenade , Prabhu Sethuramalingam 
Published: September 2020

Abstract
In this research work, surface characteristics of Ti-6Al-4V alloy have been investigated and the grinding process has been optimized using nano grinding wheel. Experiments have been conducted using L27 full factorial design. Surface roughness prediction model in nano grinding wheel for Ti alloy was developed using Response Surface Methodology (RSM) and compared with the model using Artificial Neural Network (ANN) methodology to predict the experimental behavior of the system. Grinding wheels with and without 3% nano Al2O3 powders were fabricated and their surface characteristics like surface roughness, material removal rate (MRR) and temperature were measured. Grinding was carried out on grade 5 Ti alloy with different wheels by varying input parameters. On comparing experimental and predicted results, it was found that the empirical values of surface roughness were close to the predicted values by 5%.