bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a large language model for clinical information retrieval regarding shoulder arthroplasty
Authors: Oeding Jacob F. , Lu Amy Z. , Mazzucco Michael , Fu Michael C. , Dines David M. , Warren Russell F. , Gulotta Lawrence V. , Dines Joshua S. , Kunze Kyle N. 
Published: December 2024

AbstractPurposeTo determine the scope and accuracy of medical information provided by ChatGPT‐4 in response to clinical queries concerning total shoulder arthroplasty (TSA), and to compare these results to those of the Google search engine.MethodsA patient‐replicated query for ‘total shoulder replacement’ was performed using both Google Web Search (the most frequently used search engine worldwide) and ChatGPT‐4. The top 10 frequently asked questions (FAQs), answers, and associated sources were extracted. This search was performed again independently to identify the top 10 FAQs necessitating numerical responses such that the concordance of answers could be compared between Google and ChatGPT‐4. The clinical relevance and accuracy of the provided information were graded by two blinded orthopaedic shoulder surgeons.ResultsConcerning FAQs with numeric responses, 8 out of 10 (80%) had identical answers or substantial overlap between ChatGPT‐4 and Google. Accuracy of information was not significantly different (p = 0.32). Google sources included 40% medical practices, 30% academic, 20% single‐surgeon practice, and 10% social media, while ChatGPT‐4 used 100% academic sources, representing a statistically significant difference (p = 0.001). Only 3 out of 10 (30%) FAQs with open‐ended answers were identical between ChatGPT‐4 and Google. The clinical relevance of FAQs was not significantly different (p = 0.18). Google sources for open‐ended questions included academic (60%), social media (20%), medical practice (10%) and single‐surgeon practice (10%), while 100% of sources for ChatGPT‐4 were academic, representing a statistically significant difference (p = 0.0025).ConclusionChatGPT‐4 provided trustworthy academic sources for medical information retrieval concerning TSA, while sources used by Google were heterogeneous. Accuracy and clinical relevance of information were not significantly different between ChatGPT‐4 and Google.Level of EvidenceLevel IV cross‐sectional.
Myeloproliferative neoplasm harboring both monosomy 7 and an ALK/ROS1 fusion gene: Proposal for a new disease entity
Authors: Yoshida Hideki , Osone Shinya , Konishi Madoka , Tanaka Seiji , Inaba Tohru , Imamura Toshihiko , Iehara Tomoko 
Published: December 2024

AbstractIntroductionWe present a case of a 9‐year‐old girl diagnosed with a myeloproliferative neoplasm (MPN) harboring both monosomy 7 and an ALK/ROS1 fusion gene.Case presentationThe neoplasm was resistant to conventional AML chemotherapy and required hematopoietic cell transplantation (HCT) to achieve remission.DiscussionMPNs with monosomy 7 and ALK/ROS1 fusions occur in a wide age range of children and adults, and require HCT for long‐term remission. Furthermore, these cases can be responsive to ALK inhibitors.ConclusionThis report underscores the potential need to reclassify such MPNs as a distinct entity, which has unique therapeutic implications.
Hunger and the transition from parenteral nutrition in hospitalized adults: A descriptive cohort study
Authors: Loss Sergio Henrique , Alves Klara Muller , Nunes Aline Camargo , Stefani Joel , Loureiro Giovanna Peres , Píscopo Adriana , Viana Luciana Verçoza 
Published: December 2024

AbstractBackgroundParenteral nutrition (PN) provides nutrition to patients who cannot use the digestive tract. Some patients experience delayed appetite recovery after PN, but the factors contributing to this remain unclear. This study aimed to investigate whether hospitalized patients receiving PN experience reduced hunger or appetite.MethodsA descriptive cohort study was conducted on adults who underwent PN between April 2022 and July 2023. Data on patient characteristics and nutritional support were collected from medical records. Hunger and satiety were assessed using a validated tool during three phases: clinical stability with calorie‐protein targets on PN, transition to oral/enteral feeding, and PN withdrawal. The primary outcome was the absence of hunger assessed by the tool.ResultsOf 231 screened patients, 102 were included. Among these, 62.7% reported hunger during PN. Lipid doses and energy reduction strategies did not affect hunger or satiety. Transition success to oral/enteral nutrition was 2.38 times higher in patients who experienced hunger compared to those who did not (95% CI: 1.59–3.54). Poisson regression identified higher age, inflammation, and metastatic cancer as independent factors associated with the absence of hunger.ConclusionThis study suggests that PN does not suppress hunger and that factors other than nutritional therapy (age, inflammation, and cancer) could explain the absence of appetite. Considering individual conditions and needs, these findings could guide decision‐making strategies regarding the transition from PN to oral/enteral feeding.
Determination of 23 furocoumarins in 82 food samples and implications for risk assessment
Authors: Dussy Franz , Engeli Barbara , Ryser Nadja , McCombie Gregor 
Published: December 2024

AbstractBackgroundFurocoumarins are a class of substances, which naturally occur in plants and may be present in certain foods. Roughly two dozen structurally different but related substances (congeners) have been described in plants to various degrees of depth. At sufficiently high concentrations furocoumarins pose a risk to consumers' health because of their phototoxic and photogenotoxic effects. Past studies on furocoumarin content in food usually focused on a limited number of congeners or specific food types. More information on occurrence in a broad range of foods was needed.ResultsIn order to improve occurrence data, the content of 23 furocoumarin congeners in 82 food samples, known to contain furocoumarins, is presented in full. A method was developed using liquid chromatography coupled to a triple quadrupole mass spectrometer. Samples ranging from soft drinks to vegetables were extracted with a methanol/water mixture. Chromatography and transitions in the MS/MS detection were optimised and all parameters are given. The furocoumarin content quantified ranged from 29 μg/kg in ginger to 98 mg/kg in lime juice. A table showing all the results of each congener in each food sample is presented. As more congeners were covered in this study than in the past, previous risk assessments were revisited, in order to determine if the risk for consumers has changed.ConclusionThe new occurrence data determined with the newly developed method makes a valuable contribution to the available data of furocoumarins in foods. The deducible exposure data enables a review of existing risk assessments on furocoumarins. Despite the higher number of analysed furocoumarins in this study compared to other studies, the total content for each food type was only slightly different to previously published data. Therefore, conclusions of previous risk assessments were found to be still valid: Normal dietary exposure should not lead to phototoxic effects in consumers. However, due to photogenotoxic properties of certain furocoumarins, their exposure should be reduced as much as possible and some foods should be consumed in moderation.
Multi‐Society Guideline on Cytoreductive Surgery and HIPEC: Methodology and Overview of the Results
Authors: Cinquini Michela , Kusamura Shigeki , Tralongo Antonino Carmelo , Fittipaldo Veronica Andrea , Deraco M. , Monteforte Marta 
Published: December 2024

ABSTRACTTo provide evidence‐based guidelines about Peritoneal Surface Malignancy (PSM) treatment for the Peritoneal Surfaces Oncology Group International. The GRADE ADOLOPMENT method was used to adapt recommendations from the Italian Medical Oncology Association Guideline on PSM. Seven scientific society were involved to form five guideline panels composed of 28 medical professionals from 14 countries. Panelists prioritized 7 relevant questions. A knowledge synthesis team updated evidence and summarized information. The panel agreed on seven recommendations.
Research on the Selective Extraction of Oxibendazole Residues in Animal‐Derived Food Using Molecularly Imprinted Polymers
Authors: Qiu Yue , Wang Yue , Xie Chengli , Huang Yike , Li Genrong , Xia Zhining 
Published: December 2024

ABSTRACTTo achieve specific adsorption‐based sample preparation for the poorly soluble veterinary drug oxibendazole, this study employed 4‐vinylpyridine as the functional monomer and conducted radical polymerization on the surface of functionalized silica nanoparticles to synthesize a surface molecularly imprinted polymer (OBZMIP). This OBZMIP exhibited good adsorption capacity for oxibendazole within 30 min, with its adsorption behavior conforming to the pseudo–second‐order kinetic and Langmuir models, predicting a maximum adsorption capacity of 4.93 mg/g. After five adsorption–desorption cycles, the adsorption capacity remained unchanged, demonstrating excellent reusability. In a mixed system containing eight similar compounds, the selectivity coefficients ranged from 1.3 to 16.9, indicating outstanding specific recognition ability. Utilized as an adsorbent packing material for solid‐phase extraction, the prepared OBZMIP demonstrated significantly high recovery rates in the extraction of oxibendazole from four distinct meat samples. Therefore, OBZMIP holds promising applications in the selective extraction of veterinary drug oxibendazole residues during the pretreatment of meat samples.
Differentiation of Tumors of the Upper Respiratory Tract Using Optical Metabolic Imaging
Authors: Eggert Dennis , Gaertner David , Rühm Adrian , Sroka Ronald , Arens Christoph , Davaris Nikolaos , Birkmeier Konrad , Brodschelm Andreas , Leisching Patrick , Studier Hauke , Becker Wolfgang , König Karsten , Betz Christan S. 
Published: December 2024

ABSTRACTObjectivesWith over 184,000 new cases and more than 99,000 deaths per year, malignancies of the larynx are a global health problem. Currently, a dedicated screening method enabling a direct onsite diagnosis is missing. This can lead to delayed diagnosis and worse outcomes of the patients. An endoscopic optical method enabling a direct distinction between healthy tissue, dysplastic tissue and cancerous tissue would be an ideal tool for the detection of tumors of the upper aerodigestive tract (UADT). Healthy and tumor cells differ significantly in their metabolic state due to the different metabolic pathways they use (more oxidative phosphorylation in healthy cells, more glycolysis in tumor cells). Optical metabolic imaging (OMI) measuring relative intracellular concentration of NAD(P)H and FAD redox pairs could be a promising approach for early tumor detection and differentiation of suspicious mucosal lesions.MethodsIn this study, a specially designed endoscopic two‐beam two‐photon fluorescence lifetime imaging (FLIM) system was used to perform two‐photon two‐beam FLIM of NAD(P)H and FAD to image the metabolic state in different tissue samples of the UADT. FLIM data sets of 27 tissue samples from 16 patients were recorded directly after surgery ex vivo in a special tissue culture medium at 37°C on a dedicated microscope using multiphoton excitation.ResultsBased on the FLIM measurements of NAD(P)H and FAD, six of the most common indices for the characterization of the cells' metabolism were calculated. Three of them, the ratio of the exponential coefficients (amplitudes) of the short and long lifetime components both for NAD(P)H and FAD (NAD(P)H a1/a2 ratio and FAD a1/a2 ratio) and the fluorescence lifetime redox ratio (FLIRR) enabled differentiation between healthy tissue, benign lesions, dysplastic tissue, and cancer tissue with statistical significance.ConclusionsWe showed by measurements on freshly collected tissue samples that mucosal lesions of the UADT can be differentiated using our newly designed endoscopic FLIM device. In vivo measurements in healthy volunteers were also possible. By means of this technology, differentiation of cancerous, pre‐cancerous, and healthy tissue in the UADT by OMI could be possible. Of six indices used to characterize cell metabolism we calculated, the FLIRR showed the most significant differences between tissue types.
Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry
Authors: Manicke Nicholas E. , Wedasingha Lahiru , Rydberg Magnus 
Published: December 2024

ABSTRACTMass spectrometry (MS) is a powerful analytical technique that typically involves sample preparation and online analytical separation before MS detection. Traditional methods often face bottlenecks in sample preparation and analytical separation, despite the rapid detection capabilities of MS. This review explores the integration of electrokinetic manipulations directly with the ionization step to enhance MS performance, focusing on methods that eliminate or simplify sample preparation and separation processes. Techniques such as paper spray, electrophoresis in nanoelectrospray ionization (nESI) emitters, induced nESI, counterflow gradient electrofocusing, and in‐syringe electrokinetics are highlighted for their ability to combine extraction and ionization in a single step, significantly improving throughput. The review delves into the use of electric fields during sample preparation and separations for these methods, demonstrating the efficiency of electrophoretic methods in driving extractions, crude separations, desalting, and enhanced sensitivity. The integration of these methods directly with MS ionization aims to enhance the analytical capabilities of mass spectrometry, while reducing costs and increasing throughput relative to traditional approaches.
Changes in Action Tremor in Parkinson's Disease over Time: Clinical and Neuroimaging Correlates
Authors: van den Berg Kevin R.E. , Johansson Martin E. , Dirkx Michiel F. , Bloem Bastiaan R. , Helmich Rick C. 
Published: December 2024

AbstractBackgroundThe various symptoms of Parkinson's disease (PD) may change differently over time as the disease progresses. Tremor usually manifests early in the disease, but unlike other motor symptoms, its severity may diminish over time. The cerebral mechanisms underlying these symptom‐specific longitudinal trajectories are unclear. Previous magnetic resonance imaging (MRI) studies have shown structural changes in brain regions associated with PD tremor, suggesting that structural changes over time may define clinical trajectories.ObjectivesThe aims were to investigate the longitudinal trajectory of PD tremor in relation to bradykinesia and rigidity, and assess whether tremor progression is related to structural changes in tremor‐related areas.MethodsWe used data from the Personalized Parkinson Project: a two‐year longitudinal study involving 520 PD patients and 60 healthy controls, who were measured twice clinically and with MRI. Mixed‐effects models were used to compare tremor, bradykinesia, and rigidity progression; investigate gray matter changes in tremor‐related regions (cerebello‐thalamo‐cortical circuit and pallidum); and calculate associations between symptom severity and brain structure. Associations across the whole brain were included to assess anatomical specificity.ResultsBradykinesia and rigidity worsened over 2 years, whereas tremor behaved differently: resting tremor severity remained stable, whereas postural and kinetic tremor severity decreased. Attenuation of postural and kinetic tremor was associated with, but not restricted to, atrophy in tremor‐related areas. Opposite relationships were observed for bradykinesia and rigidity.ConclusionsAction tremor (postural and kinetic) is an early symptom of PD, which reduces with disease progression. Longitudinal brain atrophy correlates with tremor and other motor symptoms in opposite ways. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
A single‐cell transcriptomic atlas of severe intrauterine adhesion
Authors: Xia Siyu , Ye Wenting , Zeng Jiajun , Song Ge , Sun Yan , Zhang Yongmei , Luo Xiaoqing , Cai Jing , Yu Hongjin , Pan Wenwei , Chen Jiayun , Yang Chuanbin , Luo Qingming , Wang Jigang , Song Yali 
Published: December 2024

AbstractIntrauterine adhesion (IUA) is a common endometrial disease caused by injury, leading to reproductive health issues. Current treatments have limited effectiveness, side effects, and high recurrence rates, especially, in severe cases. However, the underlying molecular and cellular mechanisms are largely unknown. Here we performed a comprehensive analysis by profiling integrated single‐cell transcriptomes of over 72,000 individual endometrial cells, encompassing samples from both patients with IUA and those with normal endometrium. We identified changes in cell type‐specific molecular signatures, including the inflammatory activation in immune cells, extensive damage in epithelial subpopulations, and the deposition of collagen secreted by fibroblasts subpopulations. Our results demonstrated activation of the TREM2+ macrophages, which displayed properties of inflammatory regulation. Annexin A1+ NK subpopulations exhibited the highest susceptibility among NK subtypes, displaying decreased cellular density and the most pronounced differential gene expression. Furthermore, we identified the matrix metallopeptidase 7 (MMP7+) and C‐C motif chemokine ligand 5 (CCL5+) unciliated epithelial subtype originated from pituitary tumor‐transforming gene 1 (PTTG1+) unciliated epithelium as the most vulnerable subpopulations to epithelial injury. Collectively, our study offers integrated resources of the cellular microenvironment of IUA, serving as a comprehensive cellular map of the disease in affected individuals. The insights gained from this study are expected to provide valuable resources for future diagnostic and therapeutic approaches.
Long‐Term Follow‐Up of Single‐Step Free Vascularized Lymph Node Transfer for the Management of Combined Genital and Lower Extremity Lymphedema: A Case Report
Authors: Janarthanan Ramu , Rai Shravan , Reddy G. Srilekha , Iyer Subramania 
Published: December 2024

ABSTRACTThe occurrence of genital lymphedema with lower extremity involvement is rare. There is no standard approach in the management of combined genital and lower extremity lymphedema (CGLL). The limited literature available on the management of CGLL reveals the use of multiple procedures, including vascularized lymph node transfer (VLNT), lymphovenous anastomosis (LVA), and debulking. These approaches individually target the lower extremity or genital region. There is no single‐step procedure for managing the CGLL, which involves two different anatomical regions. In this case report, we describe a single‐step surgical approach for managing CGLL using a single free VLNT. A fifty‐four‐year‐old male presented with CGLL due to filariasis, affecting the quality of life (QOL) predominantly due to genital involvement. He underwent supraclavicular lymph node transfer with an elliptical skin flap of size 5 × 3 cm, placed onto the inguinal region to target the primary lymphatic drainage of both genital and lower extremities. Venous congestion during the initial postoperative period was managed by anastomosing additional veins. The patient developed donor‐site lymphorrhea, which was managed conservatively. At 5 years follow‐up, the patient showed clinical improvement of both genital and lower extremity lymphedema with enhanced QOL. The functional status of the VLNT was confirmed by lower extremity lymphoscintigraphy with single‐photon emission computed tomography (SPECT) and scrotal lymphangiogram with indocyanine green (ICG). This case report shows the placement of a single VLNT in the inguinal region as a useful single‐step approach to improve functional outcomes in the management of CGLL.
Wideband High Gain and Low RCS Fabry–Perot Antenna Using the Single Layer Partially Reflective Surface
Authors: Ding Haoyong , Liu Ning , Jiang Tao , Sheng Xianjun , Liu Xiangyan 
Published: December 2024

ABSTRACTThis letter presents a novel wideband high gain and low radar cross section reduction (RCS) Fabry–Perot (FP) antenna using a single layer partially reflective surface (PRS). Different from the traditional PRS unit, the proposed PRS unit can broaden the gain bandwidth and reduce the in‐band RCS. The designed PRS distributes the radiated waves in‐phase through the positive phase gradient compensation and weakens the reflection of the incident waves through the phase cancellation. Compared to the previous wideband low RCS FP antennas, we first achieved the 3 dB gain bandwidth covering the 10 dB impedance bandwidth. Both the simulation and measured results verify the performance of the proposed FP antenna. The results show that the proposed FP antenna has a 10 dB impedance bandwidth of 8.6–11.8 GHz (31.4%) and an RCS reduction bandwidth of 7.9–14.0 GHz (55.7%) under the normal incidence. The 3 dB gain bandwidth and the maximum realized gain are 8.3–12.0 GHz (36.5%) and 16.3 dBi.
Food habits of nonnative Walleyes in Lake Pend Oreille, Idaho
Authors: Frawley Susan E. , Corsi Matthew P. , Dux Andrew M. , Hardy Ryan S. , Quist Michael C. 
Published: December 2024

Abstract

Objective
Walleye Sander vitreus is an important species that has been widely introduced outside of its native distribution. The goal of this study was to assess the effects of an established Walleye population in the Lake Pend Oreille (LPO) system, Idaho.

Methods
Food habits of Walleyes were described using stomach contents and stable isotopes (δ15N, δ13C). Trophic structure of the LPO system's food web was identified using stable isotopes. Annual consumption by Walleyes of important prey items was estimated using a bioenergetics model.

Result
Walleyes consumed a diversity of prey items, including macroinvertebrates and fishes. Kokanee Oncorhynchus nerka, the most frequently consumed prey item, occurred in 23% of all Walleye diets. Combined, native cyprinids and catostomids occurred in 31% of all Walleye stomachs. Select taxa (e.g., native cyprinids, kokanee) were consistently consumed by Walleyes across seasons, regions, and cohorts, whereas other taxa (e.g., Westslope Cutthroat Trout O. lewisi, Smallmouth Bass Micropterus dolomieu) were consumed inconsistently. Stable isotope analysis suggested that Walleyes occupied similar trophic positions as other top-level piscivores in the system. As Walleye age increased, δ15N increased and δ13C decreased, indicating increased consumption of pelagic prey resources and prey at higher trophic positions. The estimated biomass of kokanee consumed annually by Walleyes was 27,121 kg (95% confidence interval = 9178–61,603). Comparatively, native cyprinids represented about 46% of the total biomass of kokanee consumed by Walleyes, whereas native catostomids represented about 11% and native salmonids represented about 15% of the total biomass of kokanee consumed by Walleyes.

Conclusion
This study revealed that Walleyes consumed various fishes across the LPO system. Although kokanee were the most frequently consumed prey item, native cyprinids and catostomids (combined) occurred at similar proportions. This study contributes to our growing knowledge of the effects of nonnative Walleyes on important salmonids and native fishes in western systems.