bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study
Authors: Man Tengfei , Nolte Ilja M. , Jaju Deepali , Al-Anqoudi Zahir A.M. , Muñoz M. Loretto , Hassan Mohammed O. , Al-Yahyaee Said , Bayoumi Riad A. , Comuzzie Anthony G. , Floras John S. , van Roon Arie M. , Riese Harriëtte , Albarwani Sulayma , Snieder Harold 
Published: March 2020

Objective:
To more precisely and comprehensively estimate the genetic and environmental correlations between various indices of obesity and BP.

Methods:
We estimated heritability and genetic correlations of obesity indices with BP in the Oman family study (n = 1231). Ambulatory and office beat-to-beat BP was measured and mean values for SBP and DBP during daytime, sleep, 24-h and 10 min at rest were calculated. Different indices were used to quantify obesity and fat distribution: BMI, percentage of body fat (%BF), waist circumference and waist-to-height ratio (WHtR). SOLAR software was used to perform univariate and bivariate quantitative genetic analyses adjusting for age, age2, sex, age-sex and age2--sex interactions.

Results:
Heritabilities of BP ranged from 30.2 to 38.2% for ambulatory daytime, 16.8--21.4% for sleeping time, 32.1--40.4% for 24-h and 22--24.4% for office beat-to-beat measurements. Heritabilities for obesity indices were 67.8% for BMI, 52.2% for %BF, 37.3% for waist circumference and 37.9% for WHtR. All obesity measures had consistently positive phenotypic correlations with ambulatory and office beat-to-beat SBP and DBP (r-range: 0.14--0.32). Genetic correlations of obesity indices with SBP and DBP were higher than environmental correlations (r
G: 0.16--0.50; r
E: 0.01--0.31).

Conclusion:
The considerable genetic overlap between a variety of obesity indices and both ambulatory and office beat-to-beat BP highlights the relevance of pleiotropic genes. Future GWAS analyses should discover the specific genes both influencing obesity indices and BP to help unravel their shared genetic background.
Ectopic Lacrimal Gland Tissue: A Systematic Review
Authors: Nagendran Sonali , Alsamnan Mazen , Strianese Diego , Malhotra Raman 
Published: March 2020

We review the clinical and histopathological findings associated with ectopic lacrimal gland tissue. Ectopic lacrimal gland tissue is susceptible to neoplastic transformation in the same way as is the lacrimal gland.Supplemental Digital Content is available in the text.Purpose:To review the clinical and histopathological findings associated with ectopic lacrimal gland tissue.Methods:A systematic review of the literature on ectopic lacrimal gland tissue was performed. Studies which met clinical and histolopathological criteria for ectopic lacrimal gland tissue written in English and published in peer-reviewed journals were included.Results:Sixty-nine publications detailing 180 cases of ectopic lacrimal gland tissue were published between 1946 and 2018. Males were affected slightly more than females (57% vs. 43%) and 95% cases were unilateral. Patients presented at a mean age of 21 years, most commonly with a mass, although orbital lesions commonly presented with proptosis. The most common location for ectopic lacrimal gland tissue was epibulbar conjunctiva (62%), other locations included orbital (16%), eyelid (11%), intraocular (9%), lacrimal sac (2%), and nasal mucosa (0.6%) sites. Most lesions (86%) were locally resected. The most common histological types were complex choristomas (56%) and simple choristomas (38%). However, neoplastic transformation to pleomorphic adenoma (5%), adenocystic carcinoma (0.6%), and adenocarcinoma (0.6%) was reported.Conclusions:Ectopic lacrimal gland tissue is rare but should be considered in the differential diagnosis of masses in the epibulbar conjunctiva, eyelid, orbit, and lacrimal sac, particularly in childhood, as the diverse way it presents means that it may mimic more common choristomas. It can undergo neoplastic transformation in the same way as can the lacrimal gland and incomplete excision can result in recurrence.
Enhanced mindfulness-based stress reduction in episodic migraine: a randomized clinical trial with magnetic resonance imaging outcomes
Authors: Seminowicz David A. , Burrowes Shana A.B. , Kearson Alexandra , Zhang Jing , Krimmel Samuel R. , Samawi Luma , Furman Andrew J. , Keaser Michael L. , Gould Neda F. , Magyari Trish , White Linda , Goloubeva Olga , Goyal Madhav , Peterlin B. Lee , Haythornthwaite Jennifer A. 
Published: March 2020

AbstractWe aimed to evaluate the efficacy of an enhanced mindfulness-based stress reduction (MBSR+) vs stress management for headache (SMH). We performed a randomized, assessor-blind, clinical trial of 98 adults with episodic migraine recruited at a single academic center comparing MBSR+ (n = 50) with SMH (n = 48). MBSR+ and SMH were delivered weekly by group for 8 weeks, then biweekly for another 8 weeks. The primary clinical outcome was reduction in headache days from baseline to 20 weeks. Magnetic resonance imaging (MRI) outcomes included activity of left dorsolateral prefrontal cortex (DLPFC) and cognitive task network during cognitive challenge, resting state connectivity of right dorsal anterior insula to DLPFC and cognitive task network, and gray matter volume of DLPFC, dorsal anterior insula, and anterior midcingulate. Secondary outcomes were headache-related disability, pain severity, response to treatment, migraine days, and MRI whole-brain analyses. Reduction in headache days from baseline to 20 weeks was greater for MBSR+ (7.8 [95% CI, 6.9-8.8] to 4.6 [95% CI, 3.7-5.6]) than for SMH (7.7 [95% CI 6.7-8.7] to 6.0 [95% CI, 4.9-7.0]) (P= 0.04). Fifty-two percent of the MBSR+ group showed a response to treatment (50% reduction in headache days) compared with 23% in the SMH group (P= 0.004). Reduction in headache-related disability was greater for MBSR+ (59.6 [95% CI, 57.9-61.3] to 54.6 [95% CI, 52.9-56.4]) than SMH (59.6 [95% CI, 57.7-61.5] to 57.5 [95% CI, 55.5-59.4]) (P= 0.02). There were no differences in clinical outcomes at 52 weeks or MRI outcomes at 20 weeks, although changes related to cognitive networks with MBSR+ were observed. Enhanced mindfulness-based stress reduction is an effective treatment option for episodic migraine.
Functional Outcomes Graded With Normative Data Can Predict Postdischarge Falls and 30-Day Readmissions in Hospitalized Older Adults
Authors: Fischer Mary G. , Josef Kristine L. , Russell Jena H. 
Published: March 2020

Purpose:
Acute care physical therapists are asked to determine safe discharge plans for older patients who may be at risk for falls. Quantifying risk based on functional tests may be an effective way to educate patients on their risk and reduce falls after discharge.

Methods:
A total of 110 ambulatory patients 65 years and older on the medicine service of an acute care hospital were tested for the American Geriatric Society's top 5 fall risk factors. Results on functional tests of leg strength (5 times sit-to-stand), balance (functional reach test), gait deviation (gait speed), use of assistive device (yes or no), and history of falls (yes or no) were compared to normative data and entered into an algorithm that calculated a “fall risk score.” Participants were followed up via phone at 1, 3, 6, 9, and 12 months postdischarge.

Results:
Our tool predicted repeated falls (P = .05) but not whether or not a participant would fall. Individual factors including history of falls (odds ratio [OR] 2.4 entire cohort, OR 8.7 females) and balance impairment (OR 13.14 females) did predict falls. An incidental finding linked history of falls with 30-day readmissions for the entire cohort (OR 4.6) and in particular for females (OR 14.8).

Conclusion:
Testing functional measures prior to discharge can predict fall rate and 30-day readmission rate in older patients.
The Utilization of Vital Signs During Physical Therapy Evaluation and Intervention After Elective Total Joint Replacement: A Mixed-Methods Pilot Study
Authors: Crick James P. , Smith Nancy 
Published: March 2020

Background:
Previous literature in physical therapy has suggested that vital signs (VS) are not used as often as is recommended in clinical practice. However, this finding has not been established in the immediate postorthopedic surgery population, and physical therapy practitioners' views toward VS assessment in this population have not been previously examined. Therefore, the purpose of the current study was to (1) determine how often VS are measured via chart review, (2) describe attitudes, inclinations, and factors that may influence VS measurement by physical therapist practitioners, and (3) provide an explanation for the use or nonuse of VS in an immediate postorthopedic surgical population.

Methods:
This was a mixed-methods study with 2 phases. Phase 1 (quantitative) involved a retrospective chart review of 50 patients treated after total joint arthroplasty. Phase 2 (qualitative) involved interviewing 2 physical therapists and 1 physical therapist assistant who had treated patients in phase 1 to provide an explanation for phase 1 data. Quantitative analysis was performed on phase 1 data, and qualitative analyses were performed on phase 2 data. These data were subsequently corroborated.

Results:
Vital signs were documented on only 29 occasions over 134 therapy sessions. No correlation was found between comorbidities and VS assessment. Five major themes were induced from the qualitative data.

Discussion:
The results of this study suggest that physical therapy practitioners may practice in a manner that is inconsistent with their beliefs with respect to the assessment of VS for patients following total joint arthroplasty. Multiple explanatory mechanisms for VS utilization are suggested by physical therapy clinicians.
An exploratory descriptive study of compassion fatigue and compassion satisfaction: Examining potential risk and protective factors in advanced nurse practitioners
Authors: Glover-Stief Maggie , Jannen Sophie , Cohn Tanya 
Published: March 2020

ABSTRACT

Background:
Larger patient caseloads and increased workplace responsibility for nurse practitioners (NPs) may exacerbate factors leading to compassion fatigue (CF).

Purpose:
The purpose of this study is to analyze the rate of burnout in practicing NPs by looking at contributing factors that play a role in CF and compassion satisfaction (CS).

Methods:
A NP social media platform was used to distribute a survey to a convenience sample of 208 NPs. Data included the Professional Quality of Life Scale V (ProQOL V) tool, demographic data, and protective factor questions. The data were dissected for CF and protective factors of CS.

Results:
The relationship of mindfulness practices and levels of CS was statistically significant. The relationship between support from family, coworkers, and administration and levels of CS was also found statistically significant. A large association was found between the correlation of burnout and support from coworkers.

Implications for practice:
Findings showed an average to high level of CS with a low-to-average burnout rate among the NPs surveyed. There was a direct impact between the amount of support participants received from individual support systems and their level of CS. These findings could be beneficial for new NP graduates in establishing a sense of community while reducing the risk for burnout.
The effect of icariin for infertile women with thin endometrium
Authors: Du Juan , Lu Hua , Yu Xujun , Dong Liang , Mi Ling , Wang Jinpeng , Zheng Xia , Feng Kai 
Published: March 2020

AbstractBackground:Thin endometrium, defined as <7 mm of the endometrial thickness around ovulation period, had been identified as a negative factor on pregnancy rate of infertile women. It was considered to be the toughest part in treatment of infertility, because there was a lack of significant effect, although many drugs had been already used. Icariin was one of the major bioactive pharmaceutical constituent extracted from the Chinese herb “Ying Yang Huo,” in the genus of Epimedium, and some randomized controlled trials reported its application for thin endometrium. There is no systematic review focusing on the effective of icariin in treating infertile women with thin endometrium, so our review aims to explore it.Methods:The bibliographic database and electronic library will be systematically searched online, such as MEDLINE, EMBASE, Web of Science, Clinicaltrails.org., China National Knowledge Infrastructure Database (CNKI), Wan fang Database, China Biology Medicine Database (CBM), VIP Science Technology Periodical Database, and Cochrane Library. And the reference listed for potential literatures of included studies will be scanned additionally. Related randomized controlled trials (RCTs) will be collected and selected before January 4, 2020. Trials will be screened by independent reviewers, and the literature will be search in English or Chinese, with the search terms as “Icariin,” “Epimedium,” “infertile women,” “female infertility,” “endometrium,” “pregnancy rate.” The software for Systematic review and Meta-analysis is RevMan 5.3. The protocol and the systematic review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement.Result and conclusion:The efficacy of icariin to treat thin endometrium will be evaluated, and the conclusion will be published to help clinicians determine treatment strategy for infertile women with thin endometirum by providing medical evidence.Registration information:PROSPERO CRD42019148977.
Drug-eluting beads transarterial chemoembolization by CalliSpheres is effective and well tolerated in treating intrahepatic cholangiocarcinoma patients
Authors: Luo Jun , Zheng Jiaping , Shi Changsheng , Fang Jian , Peng Zhiyi , Huang Jing , Sun Junhui , Zhou Guanhui , Li Tiefeng , Zhu Dedong , Xu Huanhai , Hou Qinming , Ying Shihong , Sun Zhichao , Du Haijun , Xie Xiaoxi , Cao Guohong , Ji Wenbin , Han Jun , Gu Wenjiang , Guo Xiaohua , Shao Guoliang , Yu Zhihai , Zhou Jian , Yu Wenqiang , Zhang Xin , Li Ling , Hu Hongjie , Hu Tingyang , Wu Xia , Chen Yutang , Ji Jiansong , Hu Wenhao 
Published: March 2020

Abstract
This study aimed to investigate the efficacy and safety of drug-eluting beads (DEB) transarterial chemoembolization (TACE) treatment in Chinese intrahepatic cholangiocarcinoma (ICC) patients.
37 ICC patients underwent DEB-TACE treatment in CTILC study (registered on clinicaltrials.gov with registry No. NCT03317483) were included in this present study. Treatment response was assessed according to modified Response Evaluation Criteria in Solid Tumors (mRECIST). Overall survival (OS) was calculated from the time of DEB-TACE operation until the date of death from any causes. Liver function change and adverse events (AEs) were recorded during and after DEB-TACE operation.
3 (8.1%) patients achieved complete response (CR) and 22 (59.5%) patients achieved partial response (PR), with objective response rate (ORR) of 67.6%. After DEB-TACE treatment, mean OS was 376 days (95%CI: 341–412 days). Multivariate logistic regression analysis revealed that Bilobar disease (P = .040, OR: 0.105, 95% CI: 0.012–0.898) and portal vein invasion (P = .038, OR: 0.104, 95% CI: 0.012–0.881) could independently predict less possibility of ORR. Patients with ALB abnormal, TP abnormal, ALT abnormal and AST abnormal were increased at 1-week post DEB-TACE treatment (P = .034, P = .001, P < .001, P = .006, respectively), while returned to the levels at baseline after 1 to 3 months (all P > .050). Besides, most of the AEs were mild including pain, fever, vomiting, and nausea in this study.
DEB-TACE was effective and well tolerated in treating ICC patients, and bilobar disease as well as portal vein invasion were independently correlated with less probability of ORR achievement.
Development and validation of a driving simulator for evaluating the residual effects of drugs on driving performance – sensitivity analysis using zopiclone as a positive control
Authors: Iwata Mari , Iwamoto Kunihiro , Kambe Daiji , Tachibana Naoki , Ando Masahiko , Ozaki Norio 
Published: March 2020

Abstract

Introduction:
Drugs acting on the central nervous system (CNS), especially hypnotics, can impair driving. The US Food and Drug Administration started requiring pharmaceutical companies to evaluate the residual influence of CNS agents on driving performance to review their recommended doses. Although it is important for physicians to discuss automobile driving while on medication with patients to promote traffic safety, the package inserts of most CNS agents in Japan uniformly prohibit patients from driving. Although more evidence-based information regarding the effects of drugs on driving performance is needed, the current evaluation methods for driving performance abroad cannot be applied directly to Japanese drivers because of differences in traffic environments, laws, and constitutions. Therefore, we plan to establish a new driving simulator (DS) that would enable the next-day residual effects of drugs on driving performance to be examined.

Methods:
In this double-blind, randomized, placebo-controlled, crossover trial, we plan to recruit 26 healthy Japanese males aged 21 to 64 years through advertisements. During the test periods, which will take place twice every other week, the participants will undergo a DS evaluation in the hospital for 2 days/1 night after the first and last doses of the study drug following 8 days of administration. The participants in the study drug group will take zopiclone 7.5 mg at bedtime on the first and eighth days in the hospital, and placebo on the other days. The DS evaluation consists of road tracking, car following, and harsh braking tests. The primary outcome is the standard deviation of lateral position (SDLP), which is a gold standard evaluation item, in the 60-min road-tracking test. The exploratory outcomes are other evaluation items in the DS tests, in the Karolinska Sleepiness Scale sleep questionnaire, and the Profile of Mood States Second Edition rating scale. The estimated difference in the SDLP between the zopiclone and placebo groups will then be calculated.

Trial registration:
This study was registered at ClinicalTrials.gov NCT 04108351, on September 30, 2019. Ethics approval was obtained from the Ethics Committee at Hakata Clinic and the Nagoya University Medical School Hospital Bioethics Review Committee.
The association between the socioeconomic status and body pain
Authors: Yu Tong , Wei Zhen , Xu Tan , Gamber Michelle , Han Jingnan , Jiang Yan , Li Jian , Yang Daihe , Sun Wenjie 
Published: March 2020

Abstract
Pain is a significant burden among different communities, but little is known regarding the epidemiology of pain, particularly with respect to socioeconomic status (SES).
The aim of the study was to estimate the prevalence of body pain and to identify risk factors of pain in middle-aged and older Chinese.
The data were extracted from the 2008 Chinese Suboptimal Health Study that consisted of 18,316 Chinese subjects aged 18 to 65 years. Information on SES including occupation and education levels and body pain were collected. A Likert scale was used to evaluate reported body pain. We used the multiple logistic regression model to examine the association between SES and body pain.
Overall, 65.34% reported body pain (male: 60.93%; female: 69.73%). After adjustments based on sex, age, education, area of residence, marital status, smoking, drinking and health status, the results showed that students (odds ratio [OR] = 1.51; 95% confidence interval [CI]: 1.32–1.74) and professionals (OR = 1.22; 95% CI: 1.08–1.37) had significant high risk for body pain, compared with civil servants and farmers (OR = 0.64; 95% CI: 0.55–0.75) who significantly lower risk of body pain. The study demonstrates there is a significant negative association between education and reported body pain.
The results indicated an association between SES and body pain within the Chinese community. Body pain varied among different Chinese occupation-related population and people with higher education level are less like to have body pain.
Treatment of herpes labialis by photodynamic therapy
Authors: La Selva Andreia , Negreiros Renata Matalon , Bezerra Daniela Teixeira , Rosa Ellen Perin , Pavesi Vanessa Christina Santos , Navarro Ricardo Scarparo , Bello-Silva Marina Stella , Ramalho Karen Müller , Aranha Ana Cecília Corrêa , Braz-Silva Paulo Henrique , Fernandes Kristianne Porta Santos , Bussadori Sandra Kalil , Horliana Anna Carolina Ratto Tempestini 
Published: March 2020

Abstract

Background:
Lesions of herpes labialis are caused by the herpes simplex virus type 1 and cause pain and aesthetic compromise. It is characterized by the formation of small vesicles that coalesce and rupture forming extremely painful ulcers, that evolve to crusts, dry desquamations until their complete remission. Currently the treatment of these lesions is done with acyclovir. Although it diminishes the symptomatology, it causes viral resistance and does not prevent the recurrence of the lesions. It is known that antimicrobial photodynamic therapy (aPDT) has numerous advantages, among them: the reduction of the time of remission, and does not cause resistance. This protocol will determine the effectiveness of PDT in lesions of herpes labialis.

Materials and methods:
A total of 30 patients with herpes labialis in the prodromal stage of vesicles, ulcers, and crusts will be selected to participate in the study and randomized into 2 groups: G1 control and G2 experimental. After signing Research Ethics Committee and TA, patients in group G1 will undergo the standard gold treatment for herpes labialis with acyclovir and simulated PDT treatment. Patients in the experimental G2 group will be treated simulating the gold standard treatment of herpes labialis (placebo) and PDT. In all patients, saliva samples will be collected for analysis of cytokines, and will be performed exfoliative cytology in the lesions. The pain will be assessed through a pain scale and a questionnaire of quality of life related to oral health (OHIP-14) will be given to them. Patients will continue to be followed up after 7 days, 1 month, 3 months, and 6 months; if there is a recurrence of the lesion, they will contact the researchers.
Clinical registration: clinicaltrials.gov - NCT 04037475. Registered on July 2019.