bluuebunny/crossref_metadata_2025_split huggingface dataset:
Permanent urethral ligation after AUS cuff erosion: Is it ready for prime time?
Authors: Van Dyke Maia , Ortiz Nicolas , Baumgarten Adam , Ward Ellen , Baker Ryan , Hudak Steven , Morey Allen 
Published: October 2020

AbstractAimsAlthough artificial urinary sphincter (AUS) has long been the gold standard treatment for severe stress urinary incontinence, poor tissue quality in patients with prior cuff erosions may preclude this option. Formal supravesical diversion and/or bladder neck closure comprise alternative salvage options but are associated with significant morbidity and mortality. We review our experience with permanent urethral ligation (PUL) among patients deemed not to be candidates for AUS replacement following cuff erosion.MethodsFrom a single‐center database of 396 patients undergoing AUS from 2014 to 2020, 20 men underwent PUL with suprapubic tube (SPT) diversion. Clinical characteristics and outcomes were evaluated. Quality of life (QOL) was assessed using chart review, Michigan Incontinence Symptom Index (M‐ISI), and Patient Global Impression of Improvement (PGI‐I).ResultsPUL resulted in continence in 18 (90%) men; 15 after the initial surgery and three after repeat ligation. Patients were elderly (average age 75) with significant comorbidities. A total of 11 (55.5%) patients experienced complications in the 90‐day postoperative period (seven Clavien‐Dindo Grade II, four Grade III). Over an average follow‐up of 30.3 months (interquartile range: 15.75–48.75), four patients underwent cystectomy and one underwent perineal urethrostomy. In the remaining patients managed by PUL, 13 had satisfactory M‐ISI scores and indicated overall improvement on PGI‐I.ConclusionsFor men with AUS cuff erosion who are poor candidates for replacement, PUL with chronic SPT drainage represents an acceptable alternative option to restore continence and improve QOL. Though complications are not uncommon, the morbidity profile still compares favorably to more invasive formal urinary diversion.
Submillimeter features on injected acrylonitrile butadiene styrene parts: Visualization of the flow and numerical simulation
Authors: Brulez Anne‐Catherine , Boschard Cedric , Larochette Mathieu , Benayoun Stephane 
Published: October 2020

AbstractNumerical simulation of classical dimension parts with micrometric textures on their surface is still difficult to master. The limit condition of the calculations, and in particular, the implemented values, characteristics of the polymer and thermal exchanges (polymer/mold) strongly impact the results. Starting from a model with a 370 μm wide rib, by means of a numerical simulation, a study was done on the evolution of the material flow front velocities and the flow lengths in both the macroscopic part and the microgroove. This innovative visualization mold design was used to determine the velocities from an experimental perspective and to discuss the calculation conditions. On the one hand, there are significant differences regarding the choice of the no flow temperature (~ 40 K) used in the calculation code, the analytical heat transfer equation as well as the experimental results. On the other hand, according to the no flow temperature, it may be necessary to consider, during the filling phase, a perfect mold/polymer thermal contact in the groove. Depending in particular on the injection velocity and the geometry of the micro textures, a characteristic time can be determined which defines an optimal operating point for the topographic texture of the part.
Derivatization increases mosquito larvicidal activity of the sesquiterpene lactone parthenin isolated from the invasive weed Parthenium hysterophorus
Authors: Milugo Trizah K , Tchouassi David P , Kavishe Reginald A , Dinglasan Rhoel R , Torto Baldwyn 
Published: October 2020

AbstractBACKGROUNDExtracts of the invasive weed Parthenium hysterophorus (Asteraceae) have been shown to possess larvicidal activity against a wide range of disease vectors. However, the phytochemicals responsible for the larvicidal activity from this plant remain unidentified. Here, we isolated the major sesquiterpene lactone, parthenin (1) from the plant and synthesized two derivatives [ethylene glycol (2) and azide (3) derivatives] targeting the α,β‐unsaturated carbonyl group, previously known to account for its biological activity such as toxicity towards cells and microorganism. All three compounds were screened for larvicidal activity against the African malaria vector Anopheles gambiae.RESULTSThe larval mortality of ethylene glycol derivative (2) and 2α‐azidocoronopilin (3) were approximately two–four‐fold higher than that of parthenin (1) and neem oil with LC50 values of 37 and 66 mg L−1, respectively. Parthenin (1) and the positive control, neem oil, had comparable median lethal concentration (LC50) values of 154 and 121 mg L−1, respectively. In assays with binary combinations of the three compounds, larvicidal activity followed the order: parthenin (1) + 2α‐azidocoronopilin (3) (LC50 = 14 mg L−1) > parthenin (1) + ethylene glycol derivative (2) (LC50 = 109 mg L−1), > blend of 2α‐azidocoronopilin (3) and ethylene glycol derivative (2) (LC50 = 200 mg L−1).CONCLUSIONStructural modification of parthenin (1) through addition of hydroxyl groups increases its larvicidal effects. These findings advance the use of structural modification approach in the development of lead chemical molecules for potential exploitation in larval source management.
Protocol‐based collaborative design for discrete‐time switched systems with sojourn probabilities
Authors: Zhu Di , Wei Guoliang , Li Jiajia , Ding Derui 
Published: October 2020

SummaryThis article focuses on the collaborative design of a class of discrete‐time switched systems with sojourn probabilities. For the purpose of preventing the data collision, the Try‐Once‐Discard (TOD) protocol is employed to govern the information transmission between sensors and the controller. Moreover, it is worth noting that the values of sojourn probabilities, which are not given ahead, have an effect on the system stability. As a consequence, a novel collaborative design framework is established, in which the sojourn probability and static output‐feedback controller are to be designed simultaneously. By considering the effect from the TOD protocol and using the Lyapunov function related to the mode and protocol, a sufficient condition is derived to guarantee the exponential mean square stability of the closed‐loop system with a prescribed lower bound on the decay rate. Then, the desired sojourn probabilities and controller gains dependent on the corresponding mode and protocol are obtained in terms of convex optimization method with equality constraints. Subsequently, an estimation approach is provided to estimate the decay rate and decay coefficient of the closed‐loop system. Finally, one numerical example is given to testify the effectiveness of the proposed design approach.
Phosphate Anion Imprinted Cryogel Cartridges for Selective Preconcentration of Phosphorylated Amino Acids from Protein Lysate: An Alternative Sorbent for Proteome Analyses
Authors: Armutcu Canan , Tartan Çağrı , Özgür Erdoğan , Nemutlu Emirhan , Uzun Lokman 
Published: October 2020

AbstractPhosphorylation are vital in many stages such as cellular communication in metabolism, protein regulation, cell division and apoptosis. Also, the rate of phosphorylation with many diseases, including cancer, is linear. Analysis of the phosphorylated proteins is classified as phosphoproteomic and samples of hydrolyzed protein are analyzed by mass spectrometry. Although there are generally 20 amino acids in biological systems; only three (tyrosine, threonine and serine) are phosphorylated based on the hydroxyl groups they have. Thus, the preconcentration of these amino acids, which are found to be relatively low in number and amount in phosphoproteomic analyses, is of great importance for diagnosing and monitoring of the treatment. Herein, it is aimed to develop phosphate‐imprinted cryogel cartridges for the preconcentration of phosphoproteomic lysates. Cryogel cartridges were synthesized in semi‐frozen medium and characterized by scanning electron microscopy (SEM). Phosphate adsorption conditions were optimized for cryogel cartridges and optimum adsorption conditions were determined as pH of 9.80, concentration of 125 ppm and temperature of 25 °C. The selectivity of cryogel cartridges to phosphate ion was determined using chloride and carbonate ions. According to the results, cryogel cartridges are selectively recognizing both phosphate ion and phosphorylated amino acids and are suitable for cheap, efficient and fast pre‐initiation studies with reusability.
Identification of Imidazolylpyrazole Ligands as Potent Urease Inhibitors: Synthesis, Antiurease Activity and In Silico Docking Studies
Authors: Chaudhry Faryal , Naureen Sadia , Aslam Misbah , Al‐Rashida Mariya , Rahman Jameel , Huma Rahila , Fatima Javeria , Khan Mavra , Munawar Munawar Ali , Ain Khan Misbahul 
Published: October 2020

AbstractTowards discovery of effective urease inhibitors; we disclose here a hybrid series of imidazole and pyrazole motifs as potent antiurease agents. A para‐toluenesulfonic acid (TsOH) catalyzed, facile synthetic approach was employed for the preparation of targeted molecular designs in good yields upto 94 %. The novel scaffolds were characterized by different spectroscopic means (FTIR, NMR, and Mass spectrometry) and elemental analysis helped to identify the purity of these compounds. Afterwards, the derivatives was tested against Jack bean's urease enzyme to explore their inhibiting potencies. All analogues (4 a‐4 l) were found active against the studied enzyme in comparison with the standard drug thiourea (IC50=21.26±0.12 μM). However, following dibromo substituted derivatives: 4 f, 4 g, 4 h, 4 i, 4 j, 4 k, and 4 l were surfaced out as potent urease inhibitors among the series. The identified lead candidates were meta‐nitro substituted 4 k with IC50=0.7±0.002 μM and a para‐nitro containing compound 4 l with IC50=1.0±0.003 μM. As observed in docking calculations, ionic and hydrogen bonding, π‐stacking, interaction with nickel ions and other hydrophobic interactions probably stabilized the ligand bindings at the active site of urease.
In Situ Polymerized Methacrylate Based Electrolyte for Lithium‐Ion Batteries
Authors: Lee Giseung , Jung Kwangeun , Yim Taeeun 
Published: October 2020

AbstractWe propose a novel approach for incorporating a polymer electrolyte into lithium‐ion batteries by employing a pre‐polymer electrolyte (PPE). The PPE consists of a conventional carbonate‐based electrolyte that also contains 2‐(trimethylsilyloxy)ethyl methacrylate (TSEMA) as a monomer and 2,2′‐azobis(2‐methylpropionitrile) (AIBN) as an initiator; this combination can form a gel‐type polymer electrolyte after being subjected to an aging process. The results confirm that aging the PPE at 45 °C leads to the successful formation of a gel‐type polymer in the cell through an in‐situ polymerization reaction. The in‐situ‐formed gel‐type polymer electrolyte demonstrates relatively low ionic conductivity compared to conventional electrolytes, but it can still be used in lithium‐ion batteries, since an ionic network is well developed on the electrode. The combination of lithium titanium oxide anode materials and this in‐situ‐formed gel‐type polymer electrolyte is compatible with high temperatures, as the cell cycled with the methacrylate‐based in‐situ‐formed electrolyte exhibits stable cycling retention after 50 cycles.
Heterogeneous Cu(I)‐SBA‐15 Mediated Catalytic Reduction of Substituted Nitroarenes
Authors: Thennila Muthukumar , Muthumanickam Shenbagapushpam , Sivabharathy Madasamy , Yuvaraj Paneerselvam , Selvakumar Kodirajan 
Published: October 2020

AbstractA strategy for heterogeneous copper(I) mesoporous silica [Cu(I)‐SBA‐15] mediated catalytic reduction has been developed for the reduction of various nitroarenes in excellent yields. In addition to alcothermal strategy, other strategies have been attempted for the preparation of Cu(I) substituted mesoporous silica, however, the desired oxidation state is obtained only through alcothermal strategy. The crystalline phases and oxidation state of synthesized materials were characterized by XRD and XPS measurements and tested for catalytic reduction of nitroarenes. Among the tested materials, the best catalytic reduction of nitroarenes with an excellent substrate scope and good catalytic reusability was established by Cu(I)‐SBA‐15 material. The reduction kinetics and the controlled experimental studies reveal that the reaction proceeds through pseudo‐first‐order kinetics and nitrosobenzene intermediate pathway.
Correlative Cathodoluminescence Electron Microscopy: Immunolabeling Using Rare‐Earth Element Doped Nanoparticles
Authors: Keevend Kerda , Krummenacher Roman , Kungas Egle , Gerken Lukas R. H. , Gogos Alexander , Stiefel Michael , Herrmann Inge K. 
Published: October 2020

AbstractThe understanding of living systems and their building blocks relies on the assessment of structure–function relationships at the nanoscale. Although electron microscopy (EM) gives access to ultrastructural imaging with nanometric resolution, the unambiguous localization of specific molecules is challenging. An EM approach capable of localizing biomolecules with respect to the cellular ultrastructure will offer a direct route to the molecular blueprints of biological systems. In an approach departing from conventional correlative imaging, an electron beam may be used as excitation source to generate optical emission with nanometric resolution, that is, cathodoluminescence (CL). Once suitable luminescent labels become available, CL may be harnessed to enable identification of biomolecule labels based on spectral signatures rather than electron density and size. This work presents CL‐enabled immunolabeling based on rare‐earth element doped nanoparticle‐labels allowing specific molecules to be visualized at nanoscale resolution in the context of the cellular ultrastructure. Folic acid decorated nanoparticles exhibiting single particle CL emission are employed to specifically label receptors and identify characteristic receptor clustering on the surface of cancer cells. This demonstration of CL immunotargeting gives access to protein localization in the context of the cellular ultrastructure and paves the way for immunolabeling of multiple proteins in EM.
Split SIMPs with decays
Authors: Katz Andrey , Salvioni Ennio , Shakya Bibhushan 
Published: October 2020

Abstract
We discuss a minimal realization of the strongly interacting massive particle (SIMP) framework. The model includes a dark copy of QCD with three colors and three light flavors. A massive dark photon, kinetically mixed with the Standard Model hypercharge, maintains kinetic equilibrium between the dark and visible sectors. One of the dark mesons is necessarily unstable but long-lived, with potential impact on CMB observables. We show that an approximate “isospin” symmetry acting on the down-type quarks is an essential ingredient of the model. This symmetry stabilizes the dark matter and allows to split sufficiently the masses of the other states to suppress strongly their relic abundances. We discuss for the first time the SIMP cosmology with sizable mass splittings between all meson multiplets. We demonstrate that the SIMP mechanism remains efficient in setting the dark matter relic density, while CMB constraints on unstable relics can be robustly avoided. We also consider the phenomenological consequences of isospin breaking, including dark matter decay. Cosmological, astrophysical, and terrestrial probes are combined into a global picture of the parameter space. In addition, we outline an ultraviolet completion in the context of neutral naturalness, where confinement at the GeV scale is generic. We emphasize the general applicability of several novel features of the SIMP mechanism that we discuss here.
Nontraditional systems in aging research: an update
Authors: Mikuła-Pietrasik Justyna , Pakuła Martyna , Markowska Małgorzata , Uruski Paweł , Szczepaniak-Chicheł Ludwina , Tykarski Andrzej , Książek Krzysztof 
Published: October 2020

AbstractResearch on the evolutionary and mechanistic aspects of aging and longevity has a reductionist nature, as the majority of knowledge originates from experiments on a relatively small number of systems and species. Good examples are the studies on the cellular, molecular, and genetic attributes of aging (senescence) that are primarily based on a narrow group of somatic cells, especially fibroblasts. Research on aging and/or longevity at the organismal level is dominated, in turn, by experiments onDrosophila melanogaster, worms (Caenorhabditis elegans), yeast (Saccharomyces cerevisiae), and higher organisms such as mice and humans. Other systems of aging, though numerous, constitute the minority. In this review, we collected and discussed a plethora of up-to-date findings about studies of aging, longevity, and sometimes even immortality in several valuable but less frequently used systems, including bacteria (Caulobacter crescentus,Escherichia coli), invertebrates (Turritopsis dohrnii, Hydra sp., Arctica islandica), fishes (Nothobranchius sp.,Greenland shark), reptiles (giant tortoise), mammals (blind mole rats, naked mole rats, bats, elephants, killer whale), and even 3D organoids, to prove that they offer biogerontologists as much as the more conventional tools. At the same time, the diversified knowledge gained owing to research on those species may help to reconsider aging from a broader perspective, which should translate into a better understanding of this tremendously complex and clearly system-specific phenomenon.
Quality of cochlear implant rehabilitation under COVID-19 conditions
Authors: Aschendorff A. , Arndt S. , Kröger S. , Wesarg T. , Ketterer M. C. , Kirchem P. , Pixner S. , Hassepaß F. , Beck R. 
Published: October 2020

Abstract
Background
The rehabilitation process following cochlear implant (CI) surgery is carried out in a multimodal therapy according to German national guidelines and includes technical and medical aftercare. In times of the corona pandemic surgery and rehabilitation appointments were cancelled or delayed leading to a more difficult access to auditory rehabilitation. Newly implemented hygiene modalities due to the SARS-CoV‑2 pandemic have changed medical aftercare and the rehabilitation process. The aim of this study was to evaluate the quality of rehabilitation under corona conditions.

Material and methods
An anonymous survey of adult cochlear implant patients was carried out by a non-standardized questionnaire. Demographics were analyzed and the quality of medical aftercare, speech therapy, technical aftercare, psychological support and the hygiene modalities were compared to previous rehabilitation stays.

Results
In total 109 patients completed the questionnaire. The quality of rehabilitation and individual therapy were rated as qualitatively similar or improved. The threat of the pandemic and fear of corona were rated unexpectedly high with 68% and 50%, respectively. The hygiene measures during the rehabilitation stay eased subjective fears at the same time. The majority of patients were annoyed by wearing face masks but visors, protection shields and social distancing were more tolerated.

Conclusion
The implementation of the new hygiene modalities within the therapeutic rehabilitation setting was well-accepted by patients allowing access to auditory rehabilitation. A successful rehabilitation should ensure a fear-free environment by adhering to the necessary hygiene modalities.
Komplementärmedizin in der gynäkologisch-onkologischen Sprechstunde: Wie mache ich mich fit dafür?
Authors: Witt Claudia M. , Müller Twyla 
Published: October 2020

ZusammenfassungDas Thema Komplementärmedizin ist im gynäkologisch-onkologischen Praxisalltag relevant. Patientinnen mit Brustkrebs und gynäkologischen Tumoren haben ein hohes Interesse an komplementären Therapien und wenden sich damit an ihr Behandlungsteam. Dem Wunsch kann man mit unterschiedlichen Angeboten nachkommen. Man kann Patientinnen Informationen zu dem Thema geben, mit Patientinnen komplementäre Therapien auswählen oder auch Patientinnen mit komplementären Therapien behandeln. Die internationale Society for Integrative Oncology (SIO) hat Kompetenzen für Fachpersonal im Bereich der Integrativen Onkologie definiert, dazu gehören spezifische Kompetenzen aus den Kategorien Wissen, Fertigkeiten und Fähigkeiten. Die Ergebnisse aus einer Studie im Rahmen des Kompetenznetzwerks Komplementärmedizin in der Onkologie (KOKON) zeigen, dass nach einem entsprechenden Training (KOKON-KTO) in einem systematisch geführten Gespräch Empfehlungen zum Thema Komplementärmedizin in nur 20 min erfolgen können. Im Beitrag werden Beispiele von seriösen Informationsquellen dargestellt, die Elemente eines KOKON-KTO Gesprächsablaufs dargelegt und Fortbildungsmöglichkeiten erläutert.
Efficacy of surgical revision of mesh complications in prolapse and urinary incontinence surgery
Authors: Kowalik Claudia R. , Lakeman Mariëlle M. E. , Zwolsman Sandra E. , Roovers Jan-Paul W. R. 
Published: October 2020

Abstract
Introduction and hypothesis
Women with mesh-related complications in prolapse (POP) and stress-urinary incontinence (SUI) surgery may benefit from operative mesh resection to alleviate symptoms. We hypothesized that mesh resection would alleviate symptoms and aimed to evaluate risks and benefits in these women.

Methods
We carried out a cross-sectional study. Primary outcome was improvement specified as better, unchanged or worsened symptoms after mesh revision surgery. Secondary outcomes were health-related quality of life (HrQol) scores of validated questionnaires, surgical characteristics and physical findings at follow-up visits. Descriptive data were reported with mean and medians. Associations were calculated with Spearman correlation coefficient and chi-square test to determine statistical differences between groups.

Results
Fifty-nine women who underwent mesh revision surgery between 2009 and 2016 were included. After a median follow-up of 1.7 (IQR: 1.1–2.4) years, 44 women (75%) reported improvement of symptoms. No significant surgical or patient characteristics were identified that could differentiate which patients did or did not experience cure or complications.A trend was observed to better HrQol scores in women who reported overall improvement after mesh revision surgery. Seventeen (29%) women needed a subsequent operation after mesh removal.

Conclusions
This cross-sectional study shows that mesh revision surgery alleviates symptoms in 75% of women with mesh-related complications. Type of revision surgery and individual characteristics did not seem to matter to the individual chance of cure or complications. These data can facilitate the counseling of women considering mesh revision surgery.