bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of gravity effect on inferior vena cava and abdominal aortic flow using multi-posture MRI
Authors: Kadoya Yoshisuke , Miyati Tosiaki , Kobayashi Satoshi , Ohno Naoki , Gabata Toshifumi 
Published: August 2020

Background Inferior vena cava flow (IVCF) and abdominal aortic flow (AAF) are essential components of the systemic circulation. Although postural changes might alter IVCF and AAF by the gravity effect, the exact details are unknown. Purpose To evaluate the effect of gravity on IVCF and AAF using a novel magnetic resonance imaging (MRI) system that can image in any position. Material and Methods Caval velocity-mapped images were obtained using the cine phase-contrast technique in the upright and supine positions with multi-posture MRI (n = 12). The mean IVCF/AAF velocity, maximum IVCF/AAF velocity, cross-sectional area of IVC/AA, mean IVCF/AAF, maximum IVCF/AAF, and heart rate in the two positions were assessed. Results The mean IVCF velocity, maximum IVCF velocity, cross-sectional area of IVC, mean IVCF, maximum IVCF, mean AAF velocity, maximum AAF velocity, mean AAF, and maximum AAF were significantly lower in the upright position compared with the supine position ( P < 0.05 for all), with differences of 52% ± 33%, 36% ± 19%, 56% ± 18%, 26% ± 18%, 19% ± 11%, 33% ± 13%, 33% ± 22%, 42% ± 21%, and 37% ± 28%, respectively. Heart rate was significantly higher in the upright position compared with the supine position (116% ± 9.2%; P = 0.003). There were no differences in cross-sectional area of AA between the two positions (108% ± 22%; P = 0.583). Conclusion The effect of gravity decreases IVCF and AAF. Clarifying the effect of gravity on IVCF and AAF during a postural change may help to improve the management of patients with circulatory disease.
A systematic review of health economic evaluations in orthotics and prosthetics: Part 1 – prosthetics
Authors: Clarke Leigh , Dillon Michael P , Shiell Alan 
Published: August 2020

Background:
The extent to which current prosthetic health economic evaluations inform healthcare policy and investment decisions is unclear. To further the knowledge in this area, existing evidence gaps and method design issues must be identified, thereby informing the design of future research.

Objectives:
The aim of this systematic review was to identify evidence gaps, critical method design and reporting issues and determine the extent to which the literature informs a wide range of policy and investment decisions.

Study Design:
Systematic review.

Methods:
A range of databases were searched using intervention- and health economic evaluation-related terms. Issues with methodological design and reporting were evaluated using the Consolidated Health Economic Checklist – Extended and the Checklist for Health Economic Evaluation Reporting Standards.

Results:
The existing health economic evaluation literature was narrowly focused on informing within-participant component decisions. There were common method design (e.g. time horizon too short) and reporting issues (e.g. competing intervention descriptions) that limit the extent to which this literature can inform policy and investment decisions.

Conclusion:
There are opportunities to conduct a wider variety of health economic evaluations to support within- and across-sector policy and investment decisions. Changes to aspects of the method design and reporting are encouraged for future research in order to improve the rigour of the health economic evaluation evidence.

Clinical relevance:
This systematic review will inform the clinical focus and method design of future prosthetic health economic evaluations. It will also guide readers and policy-makers in their interpretation of the current literature and their understanding of the extent to which the current literature can be used to inform policy and investment decisions.
Location of the Suture Anchor in Hill-Sachs Lesion Could Influence Glenohumeral Cartilage Quality and Limit Range of Motion After Arthroscopic Bankart Repair and Remplissage
Authors: Ding Zheci , Cong Shuang , Xie Yuxue , Feng Sijia , Chen Shiyi , Chen Jiwu 
Published: August 2020

Background: No study has reported clinical evidence for cartilage change in the glenohumeral joint or the cause of loss in range of motion (ROM) after arthroscopic Bankart repair with remplissage technique (BR). Purpose: To investigate the postoperative features of glenohumeral joint cartilage, ROM, and anchor placement for remplissage at a minimum of 2 years of follow-up after BR and to analyze the correlations. Study Design: Case-control study; Level of evidence, 3. Methods: A total of 21 patients who underwent BR received follow-up for a minimum of 2 years. At both preoperative assessment and final follow-up, passive shoulder ROM, Oxford Shoulder Instability Score, Simple Shoulder Test score, and Single Assessment Numerical Evaluation score were assessed. All patients underwent 3.0-T magnetic resonance imaging (MRI) examination at final follow-up. The clinical outcomes, glenohumeral cartilage or Hill-Sachs lesion–related MRI parameters, and their potential correlations were analyzed. Results: The mean follow-up was 55.0 months (range, 24-119 months). Compared with preoperative assessment, all functional scores significantly improved ( P < .001). At the final follow-up, a significant ROM loss (>15°) of external rotation (ER) at the side (ER0) was found in 12 patients, among whom 8 patients had significant ROM loss of ER at 90° of abduction as well. Further, 12 patients with decreased ER had significantly higher signal intensity of cartilage on the anterior, middle, and posterior humeral head (anterior, P = .002; middle, P < .001; posterior, P < .001) than 9 patients with normal ER. The ratio of the width of the remplissage anchor to the diameter of the humeral head (w:d ratio) was significantly greater ( P = .031) in the decreased ER group than in the normal ER group. Correlation analysis showed that signal intensity on the posterior humeral head and ER0 loss (ΔER0) had a significantly positive correlation ( r = 0.516; P = .034), while the w:d ratio and ΔER0 had a significantly positive correlation ( r = 0.519; P = .039). Conclusion: At a minimum of 2 years of follow-up, patients who underwent BR showed significant clinical improvement compared with preoperative assessment, except for limitations in ER. The glenohumeral cartilage degeneration (higher signal intensity) after BR had a significantly positive correlation with the postoperative ER loss, which was found to be associated with a relatively medial placement of the remplissage anchor.
Characterizing Pastoral Care Utilization by Cancer Patients
Authors: Hyer J. Madison , Paredes Anghela Z. , Kelley Elizabeth Palmer , Tsilimigras Diamantis , Meyer Bonnie , Newberry Hanci , Pawlik Timothy M. 
Published: August 2020

Purpose: To assess the rate of and characterize the utilization of pastoral care (PC) among patients on their cancer treatment trajectory. Methods: Patients included in the present study were diagnosed with cancer 01/2015-08/2019 at The Ohio State Wexner Medical Center—The James. To determine which patient demographic and clinical factors were independently associated with PC utilization, a multivariable logistic regression was performed. Results: A total of 14,322 patients were included in the study and 5,166 (36.1%) had at least one visit with PC. Cancers such as brain (n = 232, 4.5% vs. n = 159, 1.7%), liver/pancreas (n = 733, 14.2% vs. 686, 7.5%), and lung (n = 1,288 vs. 24.9% vs. n = 1,113, 12.2%) were more commonly noted among patients who utilized PC services (all p < 0.001). Furthermore, compared with patients diagnosed with Stage 1 cancer, patients with more advanced disease stages had higher odds of utilizing PC services (Stage III: OR 2.37, 95% CI 2.07-2.70; Stage IV OR 2.31, 95% CI: 2.04-2.61; both p < 0.05). Interestingly, patients who had a DNR order had a markedly higher odds (OR 4.18, 95%CI 3.76-4.65, p < 0.001) of utilizing PC services. Discussion: One in three patients with cancer utilized PC services. Patients with more severe prognoses and individuals with a DNR order were more likely to utilize PC. The data suggest that PC services are an important resource for many patients and should be integrated into the treatment approach for cancer.
Monoclonal antibody extravasations: Two case reports and literature review
Authors: Rodríguez-Alarcón Alicia , Conde-Estévez David 
Published: August 2020

Introduction Extravasation is a rare complication from intravenous chemotherapy administration. Literature about monoclonal antibody (MoAb) extravasations is scarce and also conflicting in how they are classified. Case report We reported two different cases of MoAb extravasations with cetuximab and nivolumab outcome respectively. The administration site appeared inflamed and patients did not report disturbances. Management and outcome: Both extravasations did not require specific treatment. General unspecific measures suffice to properly manage these extravasations and no sequels were observed after long follow-up. Both patients received all further courses of MoAb without any adverse events. Discussion To our knowledge, we reported the first case-report of nivolumab extravasation in the literature. In addition, the cetuximab extravasation management and outcome was in accordance with previously published reports. Both MoAb may be considered as non-aggressive or neutral. We reviewed published information about MoAb extravasations. In conclusion, not all MoAb should be classified in the same category when extravasated and special precautions are warranted with conjugated MoAb and bevacizumab.
Program Evaluation of Group Transcending Self Therapy: An Integrative Modular Cognitive-Behavioral Therapy for Substance Use Disorders
Authors: Polak Kathryn , Meyer Brian L , Neale Zoe E , Reisweber Jarrod 
Published: August 2020

Objectives: Substance Use Disorders (SUDs) are increasingly prevalent among Veterans. Effective interventions for SUDs that also meet the clinical reality of open treatment groups are needed. Transcending Self Therapy: Group Integrative Cognitive Behavioral Treatment (Group TST-I-CBT) was developed to address this need. Group TST-I-CBT is a four-module, 20-session treatment designed so that a person can enter at any point in the treatment. We conducted a program evaluation of Group TST-I-CBT for veterans with SUDs. Methods: Participants were N = 68 veterans enrolled in the 28-day Substance Abuse Residential Rehabilitation Treatment Program at an urban Veterans Administration Medical Center who received either Group TST-I-CBT (N = 34) or treatment-as-usual (TAU; N = 34). Medical records were reviewed and participant treatment outcome data was retrieved. Group TST-I-CBT clients completed a knowledge and feedback form at treatment completion. Results: Compared to TAU participants, Group TST-I-CBT participants were significantly less likely to have a positive urine drug screen (UDS) during treatment (17.6% versus 0%; P = .01) and within one month post-discharge (50% versus 17.6%; P = .04). Among Group TST-I-CBT clients, Quality of Life Inventory scores significantly increased by an average of 14 points from pre- to post-treatment, t(15) = –3.31, P = .005, d = 0.83. Group TST-I-CBT clients displayed cognitive-behavioral therapy knowledge (mean correct answers ranged from 92%-100%) and rated Group TST-I-CBT as helpful, understandable, and useful (mean scores ranged from 9.3-9.6 out of 10). Conclusions: These preliminary data indicate that Group TST-I-CBT may be an effective group therapy as part of SUD treatment. A formal randomized controlled trial of Group TST-I-CBT may be warranted.
An Investigation of Potential Health Risks from Zoonotic Bacterial Pathogens Associated with Farm Rats
Authors: Badger-Emeka Lorina , Al-Mulhim Yasmeen , Al-Muyidi Fatimah , Busuhail Maram , Alkhalifah Salma , AlEid Norah 
Published: August 2020

Background: The 21st century has seen a wide range of diseases resulting from zoonotic infections, of which bacterial infections have led to outbreaks of food-borne diseases. Aim: The study looks at bacterial pathogen carriage by farm rats and their antimicrobial susceptibility, with the view of providing insights for antimicrobial surveillance. Method: Farm rats of Rattus rattus species where randomly collected alive from farms in Al-Ahsa using food baits. They were anaesthetize with urethane within 4 h of collection and were unconscious for the collection of samples. Basic bacteriological culturing methods were used for culturing of bacterial isolates on selective media while the Vitek 2 compact automated system (BioMerieux, Marcy L’Etoile, France) was used for bacteria identification and antimicrobial susceptibility test. Obtained data were analysed using chi-square and paired t-test with significant difference between sensitive and resistance to antimicrobial susceptibility taken at P < .05. Results: Isolated Gramme-negative pathogenic bacteria included strains of Escherichia coli, Pseudomonas oryzihabitans, strains of Pseudomonas aeruginosa, and Salmonella. For the Gramme-positive bacteria, 4 strains of Staphylococcus aureus were encountered. Other Gramme-positive bacteria were coagulase-negative Staphylococcal species (CoNS) as well as Staphylococcus lugdunensis. There was a 100% resistance to the penicillins and a high resistance to imipenem (71%) by the Staphylococcal isolates. Resistance was also high against the β-lactams by the Gramme-positive bacteria isolates. For the Gramme-negative bacteria, there was a higher than 50% resistance by the isolates against the following antibiotics: ampicillin (78%), amoxicillin/clavulanic acid (67%), cefotaxime (77%), ceftazidime (67%), cefepime (78%), norfloxacin (67%), nitrofurantoin (67%), and trimethoprim/sulfamethoxazole (78%). Conclusion: The results showed high antimicrobial resistance that will need monitoring for control of spread from farm rats to humans.
Social work and technology: Text mining three decades of scholarly literature (1985–2018)
Authors: Sinha Gaurav R , Larrison Christopher R 
Published: August 2020

Summary While the scholarly literature is abound with discussions of technology and its proliferation in different social work domains, evidence about what types of technologies are being used in various social work practice domains remains limited. The present study aimed to identify the larger trends in how technology has permeated the profession. The study sample comprised of 892 articles from a journal known for its contribution in publishing research on technology use in human services. Two methods were used—topic modeling and human-assisted analyses. Topic modeling was performed using MALLET, a machine learning tool which employs latent Dirichlet allocation over a fixed vocabulary for the corpus of text. Human-assisted analyses were performed using QDA Miner and MS-Excel to assist in the manual analyses. Findings In all, 29 topics in social work and 27 topics in technology domains were obtained. Social work education and mental health and clinical social work appeared as two of the top five social work domains in both topic modeling and human-assisted analyses. Management information system, communication technology, generic technology usage, and education technology were the top common topics in both types of analyses. Applications The present study findings have two applications. First, the descriptive analysis of technology adoption across diverse social work areas of research provides the first concrete evidence of how technology has been spread throughout social work. Second, the patterns of technology adoption across social work practice fields indicate some fields have limited research regarding technology.
Changes in Pulmonary Function After 3 Surgical Methods of Pulmonary Nodules Resection by Uniportal Video-Assisted Thoracoscopic Surgery
Authors: Li Jinyou , Ma Haitao , Sun Zhenyu , Sun Qi 
Published: August 2020

Objective: The purpose of this study was to evaluate the changes in pulmonary function after wedge resection, segmentectomy, and lobectomy. Methods: The patients were divided into 4 groups: lobectomy group, segmentectomy group, wedge resection group, and mediastinal surgery group. The pulmonary function was evaluated at various time points: 3 days before surgery, 1 month, 6 months, 12 months, and then 24 months after surgery. Results: The analysis results of forced expiratory volume in one second difference and breath-holding tests difference were consistent: Lobectomy group was higher than segmentectomy group, wedge resection group, and mediastinal surgery group at 4 postoperative time points ( P < .05); segmentectomy group was higher than the wedge resection group and mediastinal surgery group ( P < .05), and there was no statistical difference between the wedge resection group and the mediastinal surgery group ( P > .05). Analysis results of tidal volume difference: Lobectomy group was higher than segmentectomy group, wedge resection group, and mediastinal surgery group at 4 postoperative time points ( P < .05); segmentectomy group was higher than wedge resection group and mediastinal surgery group at 1 month after surgery ( P < .05). Analysis results of the diffusion capacity of the lung for carbon monoxide difference: lobectomy group and segmentectomy group were higher than wedge resection group and mediastinal surgery group at 4 postoperative time points ( P < .05). Analysis results of the stair-climbing test difference: lobectomy group and segmentectomy group were higher than the wedge resection group and mediastinal surgery group at 4 postoperative time points ( P < .05). Conclusion: Segmentectomy was superior to lobectomy in the protection of pulmonary function, while wedge resection was superior to segmentectomy. The recovery process of the pulmonary function was the fastest during the first 6 months after surgery.
Validation and comparison of drug eluting stent to bare metal stent for restenosis rates following vertebral artery ostium stenting: A single-center real-world study
Authors: Li Long , Wang Xu , Yang Bin , Wang Yabing , Gao Peng , Chen Yanfei , Zhu Fengshui , Ma Yan , Chi Haitao , Zhang Xiao , Bai Xuesong , Feng Yao , Dmytriw Adam A , Hong Tao , Hua Yang , Jiao Liqun , Ling Feng 
Published: August 2020

Background and purpose While drug-eluting stents (DES) have been widely applicated in coronary stenosis, uncertainty persists concerning the relative performance and clinical benefit in patients undergoing vertebral artery stenting when compared with a bare metal stent (BMS). We sought to compare in-stent restenosis (ISR) rates of DES and BMS in the treatment of vertebral artery ostium (VAO) stenosis. Materials and Methods This study analyzed a single-center prospective cohort. Over 1.5-year period (January 2014-June 2015), 137 consecutive patients underwent VAO stenting involving deployment of 76 DES and 74 BMS. Patient demographics, comorbidities, stenosis severity, stent diameters and lengths, periprocedural complications, imaging and duplex ultrasonography follow-up and recurrent symptoms were assessed. Results Technical success was achieved in all patients. Mean VAO stenosis at presentation were 82.4 ± 7.2% in the DES group and 83.3 ± 7.5% in the BMS group and were reduced to 12.5 ± 4.5% and 11.3 ± 4.0%. Mean stent diameter was 3.53 ± 0.40 mm in DES and 5.05 ± 0.40 mm in BMS (p < 0.0001). Mean follow-up was 12.3 months for DES and 11.7 months for BMS. The use of DES was associated with significant lower ISR rates compared with BMS (18.4% vs. 31.1%; OR = 2.628, p = 0.021). Recurrent symptoms rates were similar in DES vs. BMS (2.6% vs 2.7%, p = 0.680). Stent type and stent diameter were independent risk factors for ISR (P = 0.026). Conclusion Our results suggest superior efficacy of deploying DES for the treatment of VAO stenosis with lower ISR rates as compared to BMS, but do not support significant differences in periprocedural risk and recurrent symptoms rate.
Caregiver role development in chronic disease: A qualitative study of informal caregiving for veterans with diabetes
Authors: Fields Beth , Makaroun Lena , Rodriguez Keri L , Robinson Claire , Forman Jane , Rosland Ann-Marie 
Published: August 2020

Objective Support for chronic conditions such as diabetes from friends and family positively influences health management and outcomes, but limited data exist on how and why caregivers assume specific support roles for otherwise independent aging adults. We conducted a qualitative study to examine the nature of caregivers’ roles in supporting Veterans’ management of a chronic condition and caregivers’ reasons for assuming those roles, using Type 2 diabetes as an example. Methods Thirty-two interviews were conducted with Veterans with Type 2 diabetes (n = 20) and their caregivers (n = 12). Two coders independently analyzed interview transcripts using a thematic analysis approach. Results Three central roles of caregivers in diabetes management were described: direct care support, memory support/care organizer, and advocate. Three explanations for assuming caregiving roles emerged: changes in patient health, natural evolution of family roles, and caregivers’ health care experience or training. Discussion Understanding what roles caregivers fill and why is critical to designing services to support caregivers in helping improve chronic health condition management for aging adults.
Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?
Authors: Namsolleck Pawel , Moll Gert N. 
Published: August 2020

AbstractInfection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/or the Mas receptor. The unbalanced enhanced stimulation of the angiotensin II type 1 receptor causes inflammation, edema and contributes to the pathogenesis of severe acute respiratory distress syndrome. Here we hypothesize that stable, receptor-specific agonists of the angiotensin II type 2 receptor and of the Mas receptor are molecular medicines to treat COVID-19 patients. These agonists have therapeutic potential in the acute disease but in addition may reduce COVID-19-associated long-term pulmonary dysfunction and overall end-organ damage of this disease.