bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homodimerization and heterodimerization requirements of Acinetobacter baumannii SOS response coregulators UmuDAb and DdrR revealed by two-hybrid analyses
Authors: Cook Deborah , Carrington Jordan , Johnson Kevin , Hare Janelle 
Published: November 2020

The multidrug-resistant pathogen Acinetobacter baumannii displays unusual control of its SOS mutagenesis genes, as it does not encode a LexA repressor, but instead employs the UmuDAb repressor and a small protein, DdrR, that is uniquely found in Acinetobacter species. We used bacterial adenylate cyclase two-hybrid analyses to determine if UmuDAb and DdrR coregulation might involve physical interactions. Neither quantitative nor qualitative assays showed UmuDAb interaction with DdrR. DdrR hybrid proteins, however, demonstrated modest head-to-tail interactions in a qualitative assay. The similarity of UmuDAb to the homodimer-forming polymerase manager UmuD and LexA repressor proteins suggested that it may form dimers, which we observed. UmuDAb homodimerization required a free C terminus, and either small truncations or addition of a histidine tag at the C terminus abolished this homodimerization. The amino acid N100, crucial for UmuD dimer formation, was dispensable if both C termini were free to interact. However, mutation of the amino acid G124, necessary for LexA dimerization, yielded significantly less UmuDAb dimerization, even if both C termini were free. This suggests that UmuDAb forms dimers like LexA does, but may not coregulate gene expression involving a physical association with DdrR. The homodimerization of these coregulators provides insight into a LexA-independent, coregulatory process of controlling a conserved bacterial action such as the mutagenic DNA damage response.
Quasinormal modes, stability and shadows of a black hole in the 4D Einstein–Gauss–Bonnet gravity
Authors: Konoplya R. A. , Zinhailo A. F. 
Published: November 2020

AbstractRecently a D-dimensional regularization approach leading to the non-trivial $$(3+1)$$

(
3
+
1
)

-dimensional Einstein–Gauss–Bonnet (EGB) effective description of gravity was formulated which was claimed to bypass the Lovelock’s theorem and avoid Ostrogradsky instability. Later it was shown that the regularization is possible only for some broad, but limited, class of metrics and Aoki et al. (arXiv:2005.03859) formulated a well-defined four-dimensional EGB theory, which breaks the Lorentz invariance in a theoretically consistent and observationally viable way. The black-hole solution of the first naive approach proved out to be also the exact solution of the well-defined theory. Here we calculate quasinormal modes of scalar, electromagnetic and gravitational perturbations and find the radius of shadow for spherically symmetric and asymptotically flat black holes with Gauss–Bonnet corrections. We show that the black hole is gravitationally stable when ($$-16 M^2<\alpha \lessapprox 0.6 M^2$$

-
16

M
2

<
α
⪅
0.6

M
2

). The instability in the outer range is the eikonal one and it develops at high multipole numbers. The radius of the shadow $$R_{Sh}$$

R

Sh

obeys the linear law with a remarkable accuracy.
From Postcolonialism to Post-Arab Spring
Authors: Zaamout Noureddin Mahmoud 
Published: November 2020

Abstract
Hamid Dabashi (2012) saw the Arab spring revolutions as a collective act of overcoming the colonial condition and retrieving a repressed cosmopolitan worldliness that has been overshadowed by the contradictions of postcolonial politics. Dabashi posits that the pluralist and egalitarian slogans of protesters were an expression of this worldliness. In this research I assess this claim in the context of Syria. I examine the question: Has this cosmopolitan orientation resurfaced in Syria? I argue that the 2011 Syrian uprising was a retrieval of what Dabashi describes as repressed cosmopolitan worldliness. It was a grassroots attempt to bring an inclusive meaning to Syrianism, consistent with the country’s boundaries and reflective of its ethnic and religious cosmopolitanism. The transformation of the crisis into a global proxy war has resulted in the rise of hundreds of armed groups driven by competing projects that have vacated the revolutionary attempt to redefine Syrianism.
Jules Vuillemin et la philosophie analytique
Authors: Recanati François 
Published: November 2020

Résumé
Dans cette communication, qui reprend en partie les idées exposées il y a trente ans dans un article de Critique, François Recanati entreprend de caractériser la philosophie analytique en discutant une demi-douzaine de traits supposés distinctifs de la discipline : l’usage de la logique, l’importance de la philosophie du langage considérée comme philosophie première, le refus de réduire la philosophie à l’histoire de la philosophie, l’idée que la philosophie est une discipline de second niveau, l’idée qu’un progrès est possible en philosophie, ou encore – trait fondamental selon l’auteur – le caractère intersubjectif de la pratique analytique, qui rappelle la pratique scientifique et constitue ce que François Recanati appelle « l’esprit scientifique » de la philosophie analytique. A chaque étape du parcours, l’auteur s’interroge sur les aspects de cette philosophie qui pouvaient susciter des réserves de la part de Jules Vuillemin, malgré son admiration globale pour ce courant.
Impact of Winds and Southern Ocean SSTs on Antarctic Sea Ice Trends and Variability
Authors: Blanchard-Wrigglesworth Edward , Roach Lettie A. , Donohoe Aaron , Ding Qinghua 
Published: November 2020

AbstractAntarctic sea ice extent (SIE) has slightly increased over the satellite observational period (1979 to the present) despite global warming. Several mechanisms have been invoked to explain this trend, such as changes in winds, precipitation, or ocean stratification, yet there is no widespread consensus. Additionally, fully coupled Earth system models run under historic and anthropogenic forcing generally fail to simulate positive SIE trends over this time period. In this work, we quantify the role of winds and Southern Ocean SSTs on sea ice trends and variability with an Earth system model run under historic and anthropogenic forcing that nudges winds over the polar regions and Southern Ocean SSTs north of the sea ice to observations from 1979 to 2018. Simulations with nudged winds alone capture the observed interannual variability in SIE and the observed long-term trends from the early 1990s onward, yet for the longer 1979–2018 period they simulate a negative SIE trend, in part due to faster-than-observed warming at the global and hemispheric scale in the model. Simulations with both nudged winds and SSTs show no significant SIE trends over 1979–2018, in agreement with observations. At the regional scale, simulated sea ice shows higher skill compared to the pan-Antarctic scale both in capturing trends and interannual variability in all nudged simulations. We additionally find negligible impact of the initial conditions in 1979 on long-term trends.
Using Satellite Observations to Evaluate the Relationships between Ice Condensate, Latent Heat Release, and Tropical Cyclone Intensification in a Mesoscale Model
Authors: Wu Shun-Nan , Soden Brian J. , Miyamoto Yoshiaki , Nolan David S. , Buehler Stefan A. 
Published: November 2020

AbstractThis study examines the relationship between frozen hydrometeors and latent heating in model simulations and evaluates the capability of the Weather Research and Forecasting (WRF) Model to reproduce the observed frozen hydrometeors and their relationship to tropical cyclone (TC) intensification. Previous modeling studies have emphasized the importance of both the amount and location of latent heating in modulating the evolution of TC intensity. However, the lack of observations limits a full understanding of its importance in the real atmosphere. Idealized simulations using WRF indicate that latent heating is strongly correlated to the amount of ice water content, suggesting that ice water content can serve as an observable proxy for latent heat release in the mid- to upper troposphere. Based on this result, satellite observations are used to create storm-centered composites of ice water path as a function of TC intensity. The model reasonably captures the vertical and horizontal distribution of ice water content and its dependence upon TC intensity, with differences typically less than 20%. The model also captures the signature of increased ice water content for intensifying TCs, suggesting that observations of ice water content provide a useful diagnostic for understanding and evaluating model simulations of TC intensification.
Routine Screening and Linkage to Care for Hepatitis C Virus in an Urban Safety-Net Health System, 2017-2019
Authors: Hunt Bijou R. , Ahmed Christopher , Ramirez-Mercado Kimberly , Patron Christopher , Glick Nancy R. 
Published: November 2020

Objective Hepatitis C virus (HCV) is a major threat to public health in the United States. We describe and evaluate an HCV screening and linkage-to-care program, including emergency department, inpatient, and outpatient settings, in an urban safety-net health system in Chicago. Methods Sinai Health System implemented a universal HCV screening program in September 2016 that offered patient navigation services (ie, linkage to care) to patients with a positive result for HCV on an RNA test. We collected data from February 1, 2017, through January 31, 2019, on patient demographic characteristics, risk factors, and various outcomes (eg, number of patients screened, test results, proportions of new diagnoses, number of patients eligible for patient navigation services, and proportion of patients who attended their first medical appointment). We also examined outcomes by patients’ knowledge of infection. Results Of 21 018 people screened for HCV, 6% (1318/21 018) had positive test results for HCV antibody, 68% (878/1293) of whom had positive HCV RNA test results. Of these 878 patients, 68% were born during 1945-1965, 68% were male, 65% were Black, 19% were Latino, 55% were newly diagnosed, and 64% were eligible for patient navigation services. Risk factors included past or current drug use (53%), unemployment (30%), and ever incarcerated (21%). Of 562 patients eligible for navigation services, 281 (50%) were navigated to imaging services, and 203 (72%) patients who completed imaging attended their first medical appointment. Conclusion Patient navigation played a critical role in linkage success, but securing stable, long-term financial support for patient navigators is a challenge.
Impact of Minimally Invasive Esophagectomy in Post-Operative Atrial Fibrillation and Long-Term Mortality in Patients Among Esophageal Cancer
Authors: Chen LaiTe , Li BinBin , Jiang ChenYang , Fu GuoSheng 
Published: November 2020

Aims: Postoperative Atrial fibrillation (POAF) after esophagectomy may prolong stay in intensive care and increase risk of perioperative complications. A minimally invasive approach is becoming the preferred option for esophagectomy, yet its implications for POAF risk remains unclear. The association between POAF and minimally invasive esophagectomy (MIE) was examined in this study. Methods: We used a dataset of 575 patients who underwent esophagectomy. Multivariate logistic regression analysis was performed to examine the association between MIE and POAF. A cox proportional hazards model was applied to assess the long-term mortality (MIE vs open esophagectomy, OE). Results: Of the 575 patients with esophageal cancer, 62 developed POAF. MIE was negatively associated with the occurrence of POAF (Odds ratio: 0.163, 95%CI: 0.033-0.801). No significant difference was observed in long-term mortality (Odds ratio: 2.144, 95%CI: 0.963-4.775). Conclusions: MIE may reduced the incidence of POAF without compromising the survival of patients with esophageal cancer. Moreover, the specific mechanism of MIE providing this possible advantage needs to be determined by larger prospective cohort studies with specific biomarker information from laboratory tests.
Impact of early and delayed Nd:YAG laser goniopuncture on results of deep sclerectomy (5-years follow up period)
Authors: Volkova Natalia , Iureva Tatiana , Shchuko Andrey 
Published: November 2020

Purpose: To report on impact of Nd:YAG laser goniopuncture (LGP) timing on hypotensive efficacy of deep sclerectomy (DS) for open-angle glaucoma (OAG) patients. Methods: 228 patients who underwent DS followed by Nd:YAG LGP between January 2010 and December 2013, (follow up – 5 years) were enrolled into a single-center, retrospective, non-randomized, consecutive study. Subjects were divided into two groups (1 – delayed LGP, n = 116; 2 – early LGP, n = 112). Demographic variables, preoperative glaucoma medications, preceding surgeries and glaucoma severity were analyzed. Intraoperative and postoperative complications, intraocular pressure (IOP), ultrasound biomicroscopy (UBM) values were recorded. Success rate was analyzed using Kaplan-Meier curve. UBM data were the criteria for early or delayed LGP. Results: LGP was performed 3.46 ± 1.9 (1.5–6.7) months after DS in group 1, 1.12 ± 0.08 (0.9–1.5) months in group 2 ( p = 0.0001). Mean IOP before LGP in group 1 was 18.5 ± 4.7 (11.2–22.9) mm Hg; 15.7 ± 4.1 (9.1–18.5) mm Hg in group 2 ( p = 0.001). Choroidal effusion occurred in 8.6% of group 1 and 3.5% of group 2 ( p = 0.0001). Postoperative IOP: 15.6 ± 4.6 (group 1) and 15.7 ± 4.3 mm Hg (group 2) at 12 months ( p = 0.98), 16.7 ± 4.3 and 14.9 ± 1.6 mm Hg at 24 months ( p = 0.004), 16.8 ± 3.9 and 14.5 ± 3.2 mm Hg at 60 months, respectively ( p = 0.0001). Complete success rates: 68.07% and 92.59% at 12 months, 40.7% and 75.8% at 24 months, 15.2% and 48.93% at 36, 48, 60 months in groups respectively ( p = 0.0001). Conclusion: Early LGP after DS excludes TDM influence on further formation of intrascleral canal cavity and outflow pathways demonstrating pronounced hypotensive success in a long-term follow-up.
Change in skeletal muscle index and its prognostic significance in patients who underwent successful conversion therapy for initially unresectable colorectal cancer: observational study
Authors: Nozawa Hiroaki , Emoto Shigenobu , Murono Koji , Shuno Yasutaka , Kawai Kazushige , Sasaki Kazuhito , Sonoda Hirofumi , Ishii Hiroaki , Iida Yuuki , Yokoyama Yuichiro , Anzai Hiroyuki , Ishihara Soichiro 
Published: November 2020

Background: Systemic therapy can cause loss of skeletal muscle mass in colorectal cancer (CRC) patients in the neoadjuvant and palliative settings. However, it is unknown how the body composition is changed by chemotherapy rendering unresectable CRC to resectable disease or how it affects the prognosis. This study aimed at elucidating the effects of systemic therapy on skeletal muscles and survival in stage IV CRC patients who underwent conversion therapy. Methods: We reviewed 98 stage IV CRC patients who received systemic therapy in our hospital. According to the treatment setting, patients were divided into the conversion, neoadjuvant chemotherapy (NAC), and palliation groups. The cross-sectional area of skeletal muscles at the third lumbar level and changes in the skeletal muscle index (SMI), defined as the area divided by height squared, during systemic therapy were compared among patient groups. The effects of these parameters on prognosis were analyzed in the conversion group. Results: The mean SMI increased by 9.4% during systemic therapy in the conversion group ( n = 38), whereas it decreased by 5.9% in the NAC group ( n = 18) and 3.7% in the palliation group ( n = 42, p < 0.0001). Moreover, patients with increased SMI during systemic therapy had a better overall survival (OS) than those whose SMI decreased in the conversion group ( p = 0.025). The increase in SMI was an independent predictor of favorable OS on multivariate analysis (hazard ratio 0.25). Conclusions: Stage IV CRC patients who underwent conversion to resection often had an increased SMI. On the other hand, a decrease in the SMI during systemic therapy was a negative prognostic factor in such patients.
Irinotecan combined with oxaliplatin and S-1 in patients with metastatic pancreatic adenocarcinoma: a single-arm, three-centre, prospective study
Authors: Nie Keke , Zhang Ling , You Yunhong , Li Hongmei , Guo Xiuhui , Zhang Zhongfa , Zhang Chunling , Ji Youxin 
Published: November 2020

Objective: To study the efficacy and toxicity of irinotecan combined with oxaliplatin and S-1 in patients with metastatic pancreatic adenocarcinoma. Patients and methods: Previously untreated patients with cytologically or histologically confirmed metastatic pancreatic adenocarcinoma underwent a treatment regimen consisting of an intravenous infusion of irinotecan 165 mg/m2 and oxaliplatin 85 mg/m2 on day 1, and oral S-1 40 mg/m2 twice daily on days 1–14, repeating the regimen every 21 days until one of the following occurred: disease progression, intolerable toxicity, or patient death. The primary endpoint was overall survival (OS), and the secondary endpoints were progression-free survival (PFS), response rate, toxicity, and quality of life. This ongoing study had been registered on ClinicalTrials.gov, NCT03726021. Results: A total of 41 patients were enrolled in this study, 18 men and 23 women. The median PFS was 4.33 months [95% confidence interval (CI): 2.83–5.88] and the median OS was 11.00 months (95% CI: 9.16–12.84). There were no instances of a complete response; the partial response, stable disease, and disease progression rates were 39.02% (16/41), 29.27% (12/41), and 31.71% (13/41), respectively. The most common adverse side effects were mild to moderate nausea, vomiting, neutropenia, and thrombocytopenia. Grade 3 or 4 neutropenia and thrombocytopenia were observed in 29.27% (12/41) and 12.20% (5/41) of the patients, respectively. No treatment-related death was observed. Conclusion: Irinotecan combined with oxaliplatin and S-1 is a safe and effective treatment for metastatic pancreatic adenocarcinoma, and any toxicities are mild to moderate and tolerable. A larger study population is needed for further evaluation.
Hip Fracture Volume Does Not Change at a New York City Level 1 Trauma Center During a Period of Social Distancing
Authors: Haskel Jonathan D. , Lin Charles C. , Kaplan Daniel J. , Dankert John F. , Merkow David , Crespo Alexander , Behery Omar , Ganta Abhishek , Konda Sanjit R. 
Published: November 2020

Purpose: To characterize the volume and variation in orthopedic consults and surgeries that took place during a period of social distancing and pandemic. Methods: All orthopedic consults and surgeries at an urban level 1 trauma center from 3/22/20-4/30/2020 were retrospectively reviewed (the social distancing period). Data from the same dates in 2019 were reviewed for comparison. Age, gender, Score for Trauma Triage in the Geriatric and Middle Aged (STTGMA) score and injury type were queried. Operating room data collected included: type of surgery performed, inpatient or outpatient status, and if the cases were categorized as elective, trauma or infectious cases. Results: Compared to 2019, there was a 48.3% decrease in consult volume in 2020. The 2020 population was significantly older (44.0 vs 52.6 years-old, p = 0.001) and more male (65% vs 35%, p = 0.021). There were 23 COVID positive patients, 10 of which died within the collection period. Consult distribution dramatically changed, with decreases in ankle fractures, distal radius fractures and proximal humerus fractures of 76.5%, 77.4% and 55.0%, respectively. However, there was no significant difference in volume of hip, tibial shaft and femoral shaft fractures (p > 0.05). In 2020, there was a 41.4% decrease in operating room volume, no elective cases were performed, and cases were primarily trauma related. Conclusions: During a period of pandemic and social distancing, the overall volume of orthopedic consults and surgeries significantly declined. However, hip fracture volume remained unchanged. Patients presenting with orthopedic injuries were older, and at higher risk for inpatient mortality.
Assessing the Magnitude of Nonworker Deaths During Workplace Homicide Incidents: An Epidemiological Analysis Using the National Violent Death Reporting System (NVDRS)
Authors: Doucette Mitchell L. , Crifasi Cassandra K. 
Published: November 2020

Background Recent workplace homicide investigations have noted that the Census of Fatal Occupational Injuries (CFOI) has several limitations that reduce our ability to understand who dies as part of a workplace homicide incident. We sought to assess the magnitude of nonworker deaths associated with workplace homicide incidents. Methods Using National Violent Death Reporting System (NVDRS) data from 2003 to 2017, we employed a descriptive epidemiological investigation. The counts of worker and nonworker deaths during a workplace homicide incident were ascertained, as well as other characteristics (e.g., gender, age, mechanism of death, and race/ethnicity). We used multiple logistic regression to estimate the relationship between incident characteristics and the odds of having a nonworker death. Results Across the study period, there were 2,020 workplace homicides. The number of deaths associated with workplace homicide incidents increased 8.2% when considering nonworker deaths ( n = 2,186). Including those nonfatally shot as part of a workplace homicide incident increased causalities by 18.2% ( n = 2,388). If a firearm was used during perpetration, the odds that a nonworker was killed during a workplace homicide incident increased 3.76 times (95% confidence interval: 2.03, 6.96). Conclusion/Application to Practice Considering nonworkers killed as part of workplace homicide incidents is essential to understanding the true magnitude of violence associated with these incidents. Likely, it is the lethality of firearms that greatly increases the likelihood that nonworkers are killed as part a workplace homicide incident. To best understand the epidemiology of workplace homicide incident, we recommend CFOI adopt an incident-based method for coding workplace deaths.
Long Non-coding RNAs Responsive to Blast Fungus Infection in Rice
Authors: Wang Lan-Lan , Jin Jing-Jing , Li Li-Hua , Qu Shao-Hong 
Published: November 2020

AbstractBackgroundLong non-coding RNAs (LncRNAs) have emerged as important regulators in many physiological processes in plant. By high-throughput RNA-sequencing, many pathogen-associated LncRNAs were mapped in various plants, and some of them were proved to be involved in plant defense responses. The rice blast disease caused byMagnaporthe oryzae(M. oryzae) is one of the most destructive diseases in rice. However,M. oryzae-induced LncRNAs in rice is yet to be studied.FindingsWe investigated rice LncRNAs that were associated with the rice blast fungus. Totally 83 LncRNAs were up-regulated after blast fungus infection and 78 were down-regulated. Of them, the natural antisense transcripts (NATs) were the most abundant. The expression of some LncRNAs has similar pattern with their host genes or neighboring genes, suggesting acisfunction of them in regulating gene transcription level. The deferentially expressed (DE) LncRNAs and genes co-expression analysis revealed some LncRNAs were associated with genes known to be involved in pathogen resistance, and these genes were enriched in terpenoid biosynthesis and defense response by Gene Ontology (GO) enrichment analysis. Interestingly, one of up-regulated DE-intronic RNA was derived from a jasmonate (JA) biosynthetic gene, lipoxygenase RLL (LOX-RLL). Levels of JAs were significantly increased after blast fungus infection. Given that JA is known to regulate blast resistance in rice, we suggested that LncRNA may be involved in JA-mediated rice resistance to blast fungus.ConclusionsThis study identified blast fungus-responsive LncRNAs in rice, which provides another layer of candidates that regulate rice and blast fungus interactions.