bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dry ports: research outcomes, trends, and future implications
Authors: Khaslavskaya Alena , Roso Violeta 
Published: February 2020

AbstractThe concept of dry ports has gained significant interest among practitioners and researchers in the last decade. Consequently, publications on this topic have followed this development, and today there are more than 100 papers available in the Scopus and Science Direct databases, compared with only two papers in 2007. The purpose of this paper is to summarize current scientific knowledge on the phenomenon and to identify research outcomes, trends, and future research implications by conducting a systematic literature review (SLR). SLR is an explicit and reproducible method that ensures the reliability and traceability of the results. The selection of relevant papers was performed independently by each author using Rayyan QCRI software; the coding and analysis were conducted with the help of NVivo qualitative data analysis software. Findings show that the research area is largely represented by qualitative cases and optimization studies covering various aspects of dry ports. Dry port examples around the world differ based on location, functions, services, ownership, and maturity level. Although the research area is young and discrete, five main thematic areas are identified: debate on the concept, environmental impact, economic impact, performance impact, and dry ports from a network perspective.
An integrative approach to the facile functional classification of dorsal root ganglion neuronal subclasses
Authors: Giacobassi Mario J. , Leavitt Lee S. , Raghuraman Shrinivasan , Alluri Rishi , Chase Kevin , Finol-Urdaneta Rocio K. , Terlau Heinrich , Teichert Russell W. , Olivera Baldomero M. 
Published: February 2020

Significance
We have used the cellular response to a conopeptide, a highly selective K-channel blocker κM-RIIIJ, as the initial step in an integrated molecular-, cellular-, and systems-level functional analysis to describe and characterize six discrete subclasses of large-diameter mouse dorsal-root ganglion neurons. Analysis of two of these classes (proprioceptors and Aδ–low-threshold mechanoreceptors) by current-clamp electrophysiology and single-cell transcriptome analysis revealed functional differences between the subclasses based on specific molecular components. This integrated strategy is a potentially powerful tool for investigating individual neuronal cell types in functional context. This study also establishes a general approach for defining which specific ion-channel heteromeric combinations are present in different individual neuronal subtypes.
Developmental pathways of cardiorespiratory fitness from 6 to 15 years of age
Authors: Rodrigues Luis P. , Bezerra Pedro , Lopes Vitor P. 
Published: February 2020

AbstractMost of the information gathered about physical fitness of paediatric populations are cross‐sectional, resulting in normative perspectives that account for average values relative to age, but not to a comprehensive understanding of developmental individual trajectories. The aim of this study was to model the longitudinal development of cardiorespiratory fitness of boys and girls from 6 to 15 years of age, using an individual centred approach. Two hundred twenty‐nine school children (128 boys; 101 girls) were followed on their 20 metres shuttle run test (20mSRT) results from 6 to 15 years of age. Annual measurements were made during the four years of primary school, and again at grade 9th or 10th. Individual trajectories of 20mSRT development were modelled and grouped according to their similarities of change in three different developmental pathways that were included in subsequent hierarchical nested models for testing each sex developmental model of cardiorespiratory fitness. Final models including the developmental pathways showed better deviance statistics (p < .001). Interindividual slope variances were almost zero, and statistically non‐significant (0.05 boys 0.01 girls; p > .50), meaning these models capture well the existing variability, in respect to the rate of change. Individual pathways of change in the performance of 20mSRT test can be detected in childhood and adolescence. Additionally, all individual's developmental trajectories in 20mSRT can be described using three significantly different slopes. These pathways are indicative of a high, average, or low rate of change in performance over the years and differ from the normative approach.
Progressive Myocardial Apoptosis and Cardiac Dysfunction in Spontaneously Hypertensive Rats During Aging
Authors: Wu Yun , Fu Li-yun , Ruan Qin-yun , Yan Lei , Huang Chun-yan , Cai Huang-e , Huang Hui-mei , You Zi-ling , Chen Yu-peng 
Published: February 2020

Abstract

Objective
To investigate myocardial apoptosis and the expression of apoptosis-related proteins [B-cell lymphoma-2 (Bcl-2) and Bax], cardiac hypertrophy, and function in spontaneously hypertensive rats (SHR) during aging.

Methods
Male SHR (n = 36) and Wistar-Kyoto rats (WKY, n = 30) were monitored for their cardiac function from 14 to 102 weeks of age using echocardiography. Myocardial apoptosis in the subendocardium and subepicardium was analyzed using TUNEL staining. The apoptosis-related proteins (Bcl-2 and Bax) were assessed by Western blot analysis.

Results
Left ventricular mass index (LVMI) in SHR increased progressively with age. Left ventricular ejection fraction (LVEF) showed no significant difference from 14 to 66 weeks of age, but decreased significantly in SHR from 84 to 102 weeks of age. The apoptotic index (APOI) of myocardial cells in SHR increased with age, in which subendocardial APOI (APOI-endo) increased at 66 weeks and was significantly higher than the age-matched WKY (9.83 ± 3.97 vs. 4.03 ± 2.06, P &lt; 0.05). Additionally, the subepicardial APOI (APOI-epi) increased significantly at 84 weeks of age (P &lt; 0.05). Bax/Bcl-2 ratio was higher in SHR than WKY at 66 weeks (3.98 ± 0.80 vs. 0.29 ± 0.06, P &lt; 0.05), and enhanced further at 102 weeks of age (10.54 ± 1.60 vs. 0.70 ± 0.13, P &lt; 0.05). Myocardial APOI was positively correlated with LVMI (r = 0.83, P &lt; 0.01), negatively with LVEF in 66–102 weeks (r = −0.81, P &lt; 0.01), and positively with Bax/Bcl-2 ratio (r = 0.79, P &lt; 0.01).

Conclusion
Myocardial apoptosis increases with aging and is associated with progressive left ventricular remodeling and cardiac dysfunction in SHR.
Recurrent takotsubo syndrome with worsening of left ventricular outflow obstruction during haemodialysis: a case report
Authors: Takada Takuma , Jujo Kentaro , Ishida Issei , Hagiwara Nobuhisa 
Published: February 2020

Abstract

Background
The recurrence rate of takotsubo syndrome (TS) has been reported as 1.8% per patient-year while left ventricular outflow tract (LVOT) obstruction is comorbid in 10–25% of all instances of TS. The clinical course of recurrent TS with associated LVOT while on haemodialysis has rarely been reported.

Case summary
This case report involves a 60-year-old female patient receiving regular haemodialysis who was admitted for chest pain during ballroom dancing. Four years prior, she had suffered TS, and fully recovered after the hospitalization. An emergent coronary angiogram done during the second hospitalization showed no significant stenosis, and left ventriculography demonstrated mid-apical akinesia and basal hyperkinesia. Based on these findings, we diagnosed the recurrence of TS. Later in the admission, chest pain reappeared with the start of haemodialysis. A transthoracic echocardiogram demonstrated mean pressure gradient (PG) of LVOT was 58 mmHg, with systolic anterior motion of the mitral valve and basal-wall hyperkinesia. The main aetiology for her symptoms was considered as an exacerbation of LVOT obstruction due to removing intravascular volume by haemodialysis. After starting landiolol at 3 μg/kg/min, PG of LVOT and symptoms gradually improved with uptitration of landiolol. Finally, her chest pain resolved when mean PG of LVOT was down to 38 mmHg using 10 μg/kg/min of landiolol.

Discussion
To our knowledge, this is the first report of a recurrent TS case comorbid with LVOT obstruction while on regular haemodialysis. Landiolol, the ultrashort-acting beta-blocker, may be a promising therapeutic option for rapid recovery of increased PG due to LVOT obstruction.
DASH and Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) Diets Are Associated With Fewer Depressive Symptoms Over Time
Authors: Cherian Laurel , Wang Yamin , Holland Thomas , Agarwal Puja , Aggarwal Neelum , Morris Martha Clare 
Published: February 2020

Abstract

Background
Depression is common in older adults and more prevalent in those with cognitive impairment, vascular risk factors, or stroke. Nonpharmacologic strategies to reduce depression, such as diet, may be effective; however, few studies have investigated the relation.

Methods
A total of 709 participants (23.3% men, mean age 80.4), from an observational prospective cohort study were assessed annually for an average of 6.53 years of follow-up. Participants with missing or invalid baseline dietary evaluations or fewer than two depression assessments were excluded. Depressive symptoms were assessed with a 10-item version of the Center for Epidemiologic Studies Depression scale. High burden of depressive symptoms was defined as the presence of four or more depressive symptoms. Diet scores were computed using a validated food frequency questionnaire for the Dietary Approaches to Stop Hypertension (DASH) diet, Mediterranean diet, Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, and Western diets. Diet scores were modeled in tertiles. A generalized estimating equation (GEE) model was performed for the longitudinal analysis of depression as a binary outcome.

Results
Participants in the highest tertile of the DASH (β = −0.10, confidence interval [CI]: −0.20, −0.0064) and MIND (β = −0.12, CI: −0.23, −0.0092) diet scores had lower rates of depressive symptoms over time when compared to those in the respective lowest tertiles. The Western diet was positively associated with depressive symptoms over time (β = 0.093, p-trend = .05).

Conclusions
Diet may be effective in reducing depressive symptoms in older adults. A diet intervention trial may be needed to determine the optimal nutritional components for prevention of late onset depression.
Adapting Strategies for Optimal Intervention Implementation in Nursing Homes: A Formative Evaluation
Authors: Pimentel Camilla B , Mills Whitney L , Snow Andrea Lynn , Palmer Jennifer A , Sullivan Jennifer L , Wewiorski Nancy J , Hartmann Christine W 
Published: February 2020

Abstract

Background and Objectives
Nursing homes pose unique challenges for implementation of research and quality improvement (QI). We previously demonstrated successful implementation of a nursing home-led intervention to improve relationships between frontline staff and residents in 6 U.S. Department of Veterans Affairs (VA) Community Living Centers (CLCs). This article discusses early adaptations made to the intervention and its implementation to enhance frontline staff participation.

Research Design and Methods
This is a formative evaluation of intervention implementation at the first 2 participating CLCs. Formative evidence—including site visitors’ field notes, implementation facilitation records, and semistructured frontline staff interviews—were collected throughout the study period. Data analysis was informed by the Capability, Opportunity, Motivation, and Behavior model of behavior change.

Results
Adaptations were made to 5 a priori intervention implementation strategies: (a) training leaders, (b) training frontline staff, (c) adapting the intervention to meet local needs, (d) auditing and providing feedback, and (e) implementation facilitation. On the basis of a 6-month implementation period at the first CLC, we identified elements of the intervention and aspects of the implementation strategies that could be adapted to facilitate frontline staff participation at the second CLC.

Discussion and Implications
Incremental implementation, paired with ongoing formative evaluation, proved critical to enhancing capability, opportunity, and motivation among frontline staff. In elucidating what was required to initiate and sustain the nursing home-led intervention, we provide a blueprint for responding to emergent challenges when performing research and QI in the nursing home setting.
The SPOSIB SB2 Sicilian Cohort: Safety and Effectiveness of Infliximab Biosimilar SB2 in Inflammatory Bowel Diseases, Including Multiple Switches
Authors: Macaluso Fabio Salvatore , Fries Walter , Viola Anna , Centritto Andrea , Cappello Maria , Giuffrida Enrica , Privitera Antonino Carlo , Piccillo Giovita , Magnano Antonio , Vinci Elisa , Vassallo Roberto , Trovatello Antonino , Belluardo Nunzio , Giangreco Emiliano , Camilleri Salvatore , Garufi Serena , Bertolami Carmelo , Ventimiglia Marco , Renna Sara , Orlando Rosalba , Rizzuto Giulia , Orlando Ambrogio 
Published: February 2020

Abstract

Background
No data on the recently introduced infliximab (IFX) biosimilar SB2 in inflammatory bowel disease (IBD) are available.

Methods
The Sicilian Prospective Observational Study of Patients With IBD Treated With Infliximab Biosimilar SB2 is a multicenter, observational, prospective study performed among the cohort of the Sicilian Network for Inflammatory Bowel Disease. All consecutive IBD patients starting the IFX biosimilar SB2 from its introduction in Sicily (March 2018) to September 2019 (18 months) were enrolled.

Results
Two hundred seventy-six patients (Crohn disease: 49.3%, ulcerative colitis: 50.7%) were included: 127 (46.0%) were naïve to IFX and naïve to anti-tumor necrosis factor medications (anti-TNFs), 65 (23.5%) were naïve to IFX and previously exposed to anti-TNFs, 17 (6.2%) were switched from an IFX originator to SB2, 43 (15.6%) were switched from the biosimilar CT-P13 to SB2, and 24 (8.7%) were multiply switched (from IFX originator to CT-P13 to SB2). The cumulative number of infusions of SB2 was 1798, and the total follow-up time was 182.7 patient-years. Sixty-seven serious adverse events occurred in 57 patients (20.7%; incidence rate: 36.7 per 100 patient-year), and 31 of these events caused the withdrawal of the drug. The effectiveness after 8 weeks of treatment was evaluated in patients naïve to IFX (n = 192): 110 patients (57.3%) had steroid-free remission, while 56 patients had no response (29.2%). At the end of follow-up, 72 patients (26.1%) interrupted the treatment, without significant differences in treatment persistency estimations between the five groups (log-rank P = 0.15).

Conclusions
The safety and effectiveness of SB2 seem to be overall similar to those reported for the IFX originator and CT-P13.
Arsenic and Lead Determination in D&C Red No. 6 Lakes and D&C Red No. 7 Lakes Containing Barium Sulfate Using X-Ray Fluorescence Spectrometry
Authors: Hepp Nancy Morris 
Published: February 2020

Abstract

Background
Color additives requiring batch certification by the U.S. Food and Drug Administration have Code of Federal Regulations (CFR) specification limits for certain elements and are usually analyzed by x-ray fluorescence spectrometry (XRF). However, analysis of some color additives presents difficulties.

Objective
An XRF method was developed for quickly determining whether barium sulfate-containing color additives certifiable as D&C Red No. 6 lakes and D&C Red No. 7 lakes meet the CFR specifications for arsenic (As) and lead (Pb).

Method
Difficulties in preparing XRF standards and analyzing As and Pb in matrices with the heavy x-ray absorber barium (Ba) were overcome by first preparing As- and Pb-fortified cellulose, then blending color additive samples with fortified and unfortified cellulose to produce XRF calibration materials. Satisfactory compensation for changes in intensity caused by Ba absorption was achieved by measuring varying concentrations of As and Pb at several concentrations of Ba.

Results
Test samples of barium sulfate-containing D&C Red No. 6 lakes and D&C Red No. 7 lakes were analyzed by the XRF method and by an inductively coupled plasma-mass spectrometry (ICP-MS) method.

Conclusions
The ICP-MS method poses some difficulties and is time consuming. In contrast, the XRF method requires very little sample preparation, is nondestructive, uses calibrations that are stable for long periods of time, and offers acceptable determination limits (1 mg/kg As, 4 mg/kg Pb) which are less than the CFR specification limits (3 mg/kg As, 20 mg/kg Pb).

Highlights
The new XRF method is applicable for use in routine batch certification.
Recent Detection of Multiple Populations of the Tropical Bed Bug (Hemiptera: Cimicidae) Exhibiting kdr-Associated Mutations in Hawaii
Authors: Lewis Cari D , Levine Brenna A , Vargo Edward L , Schal Coby , Booth Warren 
Published: February 2020

AbstractIn recent years, bed bugs have experienced a remarkable resurgence on a near global scale. While reports have primarily focused on the common bed bug, Cimex lectularius (L.), which has resurged largely in temperate regions, in tropical regions the tropical bed bug, Cimex hemipterus (F.) (Hemiptera: Cimicidae), has reemerged as well. Recent reports of C. hemipterus introductions to subtropical and temperate regions, outside of the species natural distribution, suggest the potential for establishment and further spread. Establishment may be aided by insecticide resistance mechanisms, such as the presence of knockdown resistance (kdr)-associated mutations, which potentially confer resistance to pyrethroid, pyrethrin, and organochloride insecticides. Here, we present the first report of the detection and likely establishment of C. hemipterus in Honolulu, Hawaii, from samples collected in 2009 and 2019. Furthermore, through partial sequencing of the voltage-gated sodium channel, we report the presence of kdr-associated mutations in all samples. These findings have implications for the implementation of control strategies aimed at eradicating infestations.
New Antibiotic for Complicated UTIs
Authors: Aschenbrenner Diane S. 
Published: February 2020

Cefiderocol (Fetroja) is a newly approved cephalosporin antibiotic for adults with complicated urinary tract infections, including pyelonephritis, caused by susceptible gram-negative microorganisms when there are limited or no alternative treatments.A higher rate of all-cause mortality was seen in cefiderocol-treated patients compared with patients given other antibiotics in a clinical trial of critically ill patients with carbapenem-resistant gram-negative infections.
Mirror Therapy in the Management of Phantom Limb Pain
Authors: Yildirim Meltem , Sen Sevim 
Published: February 2020

ABSTRACT
In this case study, we investigated the efficacy of mirror therapy and online counseling in the management of phantom limb pain. The patient was a 28-year-old woman who experienced phantom limb pain after a traumatic transhumeral amputation three and a half months before initiating therapy. After a 40-minute educational session with a nurse researcher experienced in pain management and surgical nursing, the patient practiced mirror therapy at home for four weeks and kept in contact with the nurse using a mobile chat application. The patient scored the intensity of her pain before and after each practice session on a 0-to-10 numeric pain scale. The first week was difficult for her because of tiredness and the pain. In the second week she experienced less pain during the day than at night but claimed to feel much better than before. In the fourth week, she reported having difficulty sleeping, but she stated that her pain had decreased. The intensity of the pain didn't change following mirror therapy in the first week; however, her average pain score was 1.15 points lower after mirror therapy in the second week (from 4.57 to 3.42), and 1.57 points lower in the third and fourth weeks (from 5.42 to 3.85 and 4.85 to 3.28). Online counseling for mirror therapy is easy, economical, and time-saving for patient and nurse alike. However, physical and physiological problems experienced during this process may reduce the effectiveness of the therapy, highlighting the importance of a multidisciplinary approach to phantom limb pain management, which may include care from a psychologist, massage therapist, physiotherapist, and specialist in alternative therapies for relaxation, in addition to the surgeon and the nurse.
Mind–Body Therapies can Improve Pain and Opioid-Related Outcomes
Authors: Rosenberg Karen 
Published: February 2020

According to this study:

Mind–body therapies that prioritized the use in pain relief of mental techniques—such as meditation, hypnosis, guided imagery, relaxation, therapeutic suggestion, and cognitive behavioral therapy—are associated with reductions in pain and opioid dose.These therapies may also have therapeutic benefits for opioid-related problems, such as cravings and misuse.
Development and Validation of a Machine Learning Algorithm for Predicting Response to Anticholinergic Medications for Overactive Bladder Syndrome
Authors: Sheyn David , Ju Mingxuan , Zhang Sixiao , Anyaeche Caleb , Hijaz Adonis , Mangel Jeffrey , Mahajan Sangeeta , Conroy Britt , El-Nashar Sherif , Ray Soumya 
Published: February 2020

(Abstracted from Obstet Gynecol 2019;134:946–957)
It has been estimated that overactive bladder (OAB) syndrome affects as many as 17.5 million women in the United States, including up to 30% of women older than 65 years. Up to 70% of OAB cases are considered idiopathic.
Medicaid and Medicare Payer Status Are Associated With Worse Surgical Outcomes in Gynecologic Oncology
Authors: Ahmad Tessnim R. , Chen Lee-May , Chapman Jocelyn S. , Chen Lee-Lynn 
Published: February 2020

(Abstracted from Gynecol Oncol 2019;155:93–97)
Medicaid provides health insurance for Americans earning less than 133% of the federal poverty limit, amounting to approximately $35,000 for a family of 4, and covering approximately 1 in 5 Americans. Medicaid participants may have decreased access to care despite having insurance, as providers are less likely to accept Medicaid compared with private insurance.
The Influence of a Positive Empathetic Interaction on Conditioned Pain Modulation and Manipulation-induced Analgesia in People With Lateral Epicondylalgia
Authors: Muhsen Ahmad , Moss Penny , Gibson William , Walker Bruce , Jacques Angela , Schug Stephan , Wright Anthony 
Published: February 2020

Objective:
Conditioned pain modulation (CPM) and manipulation-induced analgesia (MIA) are 2 forms of endogenous analgesia. Many forms of analgesia can be influenced by the nature of the patient-clinician interaction. The aim of this study was to evaluate the influence of an empathetic and supportive interaction on CPM and MIA in people with lateral epicondylalgia (LE).

Material and Methods:
In a double-blind, randomized, controlled trial, 68 participants with LE were assigned to 2 groups: the empathetic and neutral interaction groups. The interactions were carried out by a trained, professional role-play actor, playing the part of a research assistant. The research assistant actor spent 15 minutes before CPM and MIA assessment interacting with the participants in an empathetic or neutral manner. Immediately after the interaction, a blinded assessor measured pressure pain threshold at the symptomatic elbow and ipsilateral wrist during CPM and MIA testing. Linear mixed models were used to evaluate differences in CPM and MIA responses between the interaction groups.

Results:
There was a significant difference in Consultation and Relational Empathy scores between the groups (P<0.001), indicating that the intervention group experienced a more empathic interaction. Both groups showed a significant increase in pressure pain threshold measures, indicative of a CPM and MIA analgesic response (P<0.001), however, the analgesic responses were greater in the group that had experienced a supportive, empathetic interaction (post CPM, wrist: P<0.001; elbow: P=0.001) (post MIA wrist: P<0.001; elbow: P=0.001).

Discussion:
A single session of empathetic interaction positively influenced both CPM and MIA responses in people with LE.