bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motion Feasibility Framework for Remotely Operated Vehicles Based on Dynamic Positioning Capability
Authors: Ramírez-Macías Juan A. , Vásquez Rafael E. , Sørensen Asgeir J. , Sævik Svein 
Published: May 2020

Abstract
Knowing whether a remotely operated vehicle (ROV) is able to operate at certain foreknown environmental conditions is a question relevant to different actors during the vehicle’s life cycle: during design stages, buying an ROV, planning operations, and performing an operation. This work addresses a framework to assess motion feasibility in ROVs by using the concept of ROV-dynamic positioning capability (ROV-DPCap). Within the proposed framework, the ROV-DPCap number is defined to measure motion capability, and ROV-DPCap plots are used to illustrate results, for quasi-static standard (L2) and site-specific (L2s) conditions, and dynamic standard (L3) and site-specific (L3s) conditions. Data are computed by steady-state or time-domain simulations from the ROV model, depending on the desired analysis. To illustrate the use of the framework, numerical examples for L2 and L2s motion feasibility analyses for NTNU’s ROV Minerva are provided. Motion feasibility can be used to know whether an ROV is appropriately designed for a specific operation and choose the appropriate one for a certain need, for instance, when designing the DP system components or planning an operation from the environmental data and ROV-specific information. As expected, predictions can be improved when more detailed information about the ROV appears; the same framework can be used to provide more detailed answers to motion feasibility-related questions. The results are likely to be straightforwardly understood by people whose work/training is ROV related and can interpret the graphic results for different operation scenarios.
The Transition From Rebound to Bonding in High-Velocity Metallic Microparticle Impacts: Jetting-Associated Power-Law Divergence
Authors: Sun Yuchen , Veysset David , Nelson Keith A. , Schuh Christopher A. 
Published: May 2020

Abstract
A metallic microparticle impacting a metallic substrate with sufficiently high velocity will adhere, assisted by the emergence of jetting—the splash-like extrusion of solid matter at the periphery of the impact. In this work, we compare real-time observations of high-velocity single-microparticle impacts to an elastic–plastic model to develop a more thorough understanding of the transition between the regimes of rebound and bonding. We first extract an effective dynamic yield strength for copper from prior experiments impacting alumina spheres onto copper substrates. We then use this dynamic yield strength to analyze impacts of copper particles on copper substrates. We find that up to moderate impact velocities, impacts and rebound velocities follow a power-law behavior well-predicted on the basis of elastic-perfectly plastic analysis and can be captured well with a single value for the dynamic strength that subsumes many details not explicitly modeled (rate and hardening effects and adiabatic heating). However, the rebound behavior diverges from the power-law at higher impact velocities approaching bonding, where jetting sets on. This divergence is associated with additional lost kinetic energy, which goes into the ejection of the material associated with jetting and into breaking incipient bonds between the particle and substrate. These results further support and develop the idea that jetting facilitates bonding where a critical amount of bond formation is required to effect permanent particle deposition and prevent the particle from rebounding.
Mechanism-Based Energy Regularization in Computational Modeling of Quasibrittle Fracture
Authors: Gorgogianni Anna , Eliáš Jan , Le Jia-Liang 
Published: May 2020

AbstractQuasibrittle materials are featured by a strain-softening constitutive behavior under many loading scenarios, which could eventually lead to localization instability. It has long been known that strain localization would result in spurious mesh sensitivity in finite element (FE) simulations. Previous studies have shown that, for the case of fully localized damage, the mesh sensitivity can be mitigated through energy regularization of the material constitutive law. However, depending on the loading configuration and structural geometry, quasibrittle structures could exhibit a complex damage process, which involves both localized and diffused damage patterns at different stages of loading. This study presents a generalized energy regularization method that considers the spatial and temporal evolution of damage pattern. The method introduces a localization parameter, which describes the local damage pattern. The localization parameter governs the energy regularization of the constitutive model, which captures the transition from diffused to localized damage during the failure process. The method is cast into an isotropic damage model, and is further extended to rate-dependent behavior. The energy regularization scheme is directly incorporated into the kinetics of damage growth. The model is applied to simulate static and dynamic failures of ceramic specimens. It is shown that the present model is able to effectively mitigate the spurious mesh sensitivity in FE simulations of both types of failure. The present analysis demonstrates the essential role of mechanism-based energy regularization of constitutive relation in FE simulations of quasibrittle fracture.
Community health workers and early detection of breast cancer in low-income and middle-income countries: a systematic scoping review of the literature
Authors: O'Donovan James , Newcomb Ashley , MacRae MacKenzie Clark , Vieira Dorice , Onyilofor Chinelo , Ginsburg Ophira 
Published: May 2020

BackgroundBreast cancer is the leading cause of female mortality in low-income and middle-income countries (LMICs). Early detection of breast cancer, either through screening or early diagnosis initiatives, led by community health workers (CHWs) has been proposed as a potential way to address the unjustly high mortality rates. We therefore document: (1) where and how CHWs are currently deployed in this role; (2) how CHWs are trained, including the content, duration and outcomes of training; and (3) the evidence on costs associated with deploying CHWs in breast cancer early detection.MethodsWe conducted a systematic scoping review and searched eight major databases, as well as the grey literature. We included original studies focusing on the role of CHWs to assist in breast cancer early detection in a country defined as a LMIC according to the World Bank.Findings16 eligible studies were identified. Several roles were identified for CHWs including awareness raising and community education (n=13); history taking (n=7); performing clinical breast examination (n=9); making onward referrals (n=7); and assisting in patient navigation and follow-up (n=4). Details surrounding training programmes were poorly reported and no studies provided a formal cost analysis.ConclusionsDespite the relative paucity of studies addressing the role of CHWs in breast cancer early detection, as well as the heterogeneity of existing studies, evidence suggests that CHWs can play a number of important roles in breast cancer early detection initiatives in LMICs. However, if they are to realise their full potential, they must be appropriately supported within the wider health system.
Norovirus gastroenteritis outbreaks in military units: a systematic review
Authors: Queiros-Reis Luis , Lopes-João A , Mesquita J R , Penha-Gonçalves C , Nascimento M S J 
Published: May 2020

IntroductionNorovirus gastroenteritis is one of the most frequent causes of personnel unavailability in military units, being associated with significant morbidity and degradation of their operational effectiveness. The disease is usually mild but can be severe and life-threatening in young and healthy soldiers, who are prone to dehydration due to intensive daily activity. Despite its impact, the full extent of the norovirus gastroenteritis burden in military forces remains unclear. This systematic review aims to evaluate the impact and ascertain clinical and epidemiological features of norovirus outbreaks that have occurred in the military forces.MethodsThe systematic review followed the Preferred Reporting Items for Systemic Reviews and Meta-Analysis (PRISMA) guidelines and used three databases: PubMed, Scopus, and LILACs. Papers published up to 1 September 2019 were included without restrictions if they reported one or more outbreaks in the military forces on active duty, either on national territories or deployed overseas.ResultsA total of 343 papers were retrieved from the literature search. After inclusion/exclusion criteria a total of 39 eligible papers were considered. From 1988 (first reported outbreak in the military) to 2018 more than 101 norovirus outbreaks have been reported in the military, accounting for at least 24 332 cases. Secondary transmission was emphasised as the main route of norovirus transmission in the military forces, with eating outside the military setting an important route for the primary cases.ConclusionsThe present review highlights that norovirus gastroenteritis has been a burden to military troops both in combat and on peacekeeping operations. Norovirus disease has been shown to exact a substantial toll on mission readiness and operational effectiveness. It is noteworthy that the impact of norovirus outbreaks among military units is underestimated because the literature review retrieved information from the armed forces from only nine countries.
Building scale and well-being in a hospice: a qualitative exploration
Authors: Annemans Margo , Coomans Koen , Heylighen Ann 
Published: May 2020

ObjectiveThis study explored how built space plays out in palliative care, focusing on spatial aspects that could support or hamper patients’, relatives’ and caregivers’ well-being.MethodsThis study was conducted in a freestanding small-scale hospice combining a residential part for eight guests with a day-care part for groups of about five persons. Observations were combined with semistructured, individual interviews with eight guests (sometimes accompanied by relatives) and three focus-group interviews with staff, volunteers and relatives. All interviews were audio-recorded and transcribed verbatim. Data were analysed based on the Qualitative Analysis Guide of Leuven.ResultsThe most important spatial aspects that impact on physical and social well-being in palliative care turned out to be the building scale and physical proximity. The small-scale setting counters the (often negative) association of palliative care with hospital environments. When the medical condition of the guest allows, it makes communal or outdoor spaces reachable, which enhances emotional and social well-being. In worse conditions, it still makes that care and nature are always nearby. The compactness of communal spaces intensifies social contacts.ConclusionsThe building scale and physical proximity play out in the relationship between the building and its surroundings, between the residential and the day-care parts and among people within the building. Future research could investigate to what extent these spatial aspects are relevant in more conventional palliative care units or even in general hospital wards.
Firearm access and adolescent suicide risk: toward a clearer understanding of effect size
Authors: Swanson Sonja A , Eyllon Mara , Sheu Yi-Han , Miller Matthew 
Published: May 2020

BackgroundStrong and consistent associations between access to firearms and suicide have been found in ecologic and individual-level observational studies. For adolescents, a seminal case–control study estimated that living in a home with (vs without) a firearm was associated with a fourfold increase in the risk of death by suicide.MethodsWe use data from a nationally representative study of 10 123 US adolescents aged 13–18 years to (1) measure how much adolescents who live in a home with a firearm differ from those who do not in ways related to their risk of suicide, and (2) incorporate these differences into an updated effect estimate of the risk of adolescent suicide attributable to living in a home with firearms.ResultsAlmost one-third (30.7%) of adolescents reported living in a home with firearms. Relative to those who did not, adolescents reporting living in a home with a firearm were slightly more likely to be male, older and reside in the South and rural areas, but few differences were identified for mental health characteristics. The effect size found by Brent and colleagues appeared robust to sources of possible residual confounding: updated relative risks remained above 4.0 across most sensitivity analyses and at least 3.1 in even the most conservative estimates.ConclusionsAlthough unmeasured confounding and other biases may nonetheless remain, our updated estimates reinforce the suggestion that adolescents’ risk of suicide was increased threefold to fourfold if they had lived in homes with a firearm compared with if they had not.
De novomutations in the X-linkedTFE3gene cause intellectual disability with pigmentary mosaicism and storage disorder-like features
Authors: Lehalle Daphné , Vabres Pierre , Sorlin Arthur , Bierhals Tatjana , Avila Magali , Carmignac Virginie , Chevarin Martin , Torti Erin , Abe Yuichi , Bartolomaeus Tobias , Clayton-Smith Jill , Cogné Benjamin , Cusco Ivon , Duplomb Laurence , De Bont Eveline , Duffourd Yannis , Duijkers Floor , Elpeleg Orly , Fattal Aviva , Geneviève David , Guillen Sacoto Maria J , Guimier Anne , Harris David J , Hempel Maja , Isidor Bertrand , Jouan Thibaud , Kuentz Paul , Koshimizu Eriko , Lichtenbelt Klaske , Loik Ramey Valerie , Maik Miriam , Miyakate Sakoto , Murakami Yoshiko , Pasquier Laurent , Pedro Helio , Simone Laurie , Sondergaard-Schatz Krista , St-Onge Judith , Thevenon Julien , Valenzuela Irene , Abou Jamra Rami , van Gassen Koen , van Haelst Mieke M , van Koningsbruggen Silvana , Verdura Edgard , Whelan Habela Christa , Zacher Pia , Rivière Jean-Baptiste , Thauvin-Robinet Christel , Betschinger Joerg , Faivre Laurence 
Published: May 2020

IntroductionPigmentary mosaicism (PM) manifests by pigmentation anomalies along Blaschko’s lines and represents a clue toward the molecular diagnosis of syndromic intellectual disability (ID). Together with new insights on the role for lysosomal signalling in embryonic stem cell differentiation, mutations in the X-linked transcription factor 3 (TFE3) have recently been reported in five patients. Functional analysis suggested these mutations to result in ectopic nuclear gain of functions.Materials and methodsSubsequent data sharing allowed the clustering ofde novo TFE3variants identified by exome sequencing on DNA extracted from leucocytes in patients referred for syndromic ID with or without PM.ResultsWe describe the detailed clinical and molecular data of 17 individuals harbouring ade novo TFE3variant, including the patients that initially allowed reportingTFE3as a new disease-causing gene. The 12 females and 5 males presented with pigmentation anomalies on Blaschko’s lines, severe ID, epilepsy, storage disorder-like features, growth retardation and recognisable facial dysmorphism. The variant was at a mosaic state in at least two male patients. All variants were missense except one splice variant. Eleven of the 13 variants were localised in exon 4, 2 in exon 3, and 3 were recurrent variants.ConclusionThis series further delineates the specific storage disorder-like phenotype with PM ascribed tode novo TFE3mutation in exons 3 and 4. It confirms the identification of a novel X-linked human condition associated with mosaicism and dysregulation within the mechanistic target of rapamycin (mTOR) pathway, as well as a link between lysosomal signalling and human development.
Evidence for polygenic and oligogenic basis of Australian sporadic amyotrophic lateral sclerosis
Authors: McCann Emily P , Henden Lyndal , Fifita Jennifer A , Zhang Katharine Y , Grima Natalie , Bauer Denis C , Chan Moi Fat Sandrine , Twine Natalie A , Pamphlett Roger , Kiernan Matthew C , Rowe Dominic B , Williams Kelly L , Blair Ian P 
Published: May 2020

BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with phenotypic and genetic heterogeneity. Approximately 10% of cases are familial, while remaining cases are classified as sporadic. To date, >30 genes and several hundred genetic variants have been implicated in ALS.MethodsSeven hundred and fifty-seven sporadic ALS cases were recruited from Australian neurology clinics. Detailed clinical data and whole genome sequencing (WGS) data were available from 567 and 616 cases, respectively, of which 426 cases had both datasets available. As part of a comprehensive genetic analysis, 853 genetic variants previously reported as ALS-linked mutations or disease-associated alleles were interrogated in sporadic ALS WGS data. Statistical analyses were performed to identify correlation between clinical variables, and between phenotype and the number of ALS-implicated variants carried by an individual. Relatedness between individuals carrying identical variants was assessed using identity-by-descent analysis.ResultsForty-three ALS-implicated variants from 18 genes, includingC9orf72,ATXN2,TARDBP, SOD1, SQSTM1andSETX,were identified in Australian sporadic ALS cases. One-third of cases carried at least one variant and 6.82% carried two or more variants, implicating a potential oligogenic or polygenic basis of ALS. Relatedness was detected between two sporadic ALS cases carrying aSOD1p.I114T mutation, and among three cases carrying aSQSTM1p.K238E mutation. Oligogenic/polygenic sporadic ALS cases showed earlier age of onset than those with no reported variant.ConclusionWe confirm phenotypic associations among ALS cases, and highlight the contribution of genetic variation to all forms of ALS.
The M-sigma relation of supermassive black holes from the scalar field dark matter
Authors: Lee Jae-Weon , Kim Hyeong-Chan , Lee Jungjai 
Published: May 2020

We show a relation between the mass of supermassive black holes in galaxies and the velocity dispersions of their bulges in the scalar field or the Bose–Einstein condensate dark matter model. The gravity of the central black holes changes boundary conditions of the scalar field at the galactic centers. Owing to the wave nature of the dark matter, this significantly changes the galactic dark matter halo profiles even though the black holes are much lighter than the bulges. As a result the heavier the black holes are, the more compact the bulges are, and hence the larger the velocity dispersions are. This tendency is verified by a numerical study showing the M-sigma relation reproduced with the dark matter particle mass [Formula: see text] eV.
On the discrete version of the black hole solution
Authors: Khatsymovsky V. M. 
Published: May 2020

A Schwarzschild-type solution in Regge calculus is considered. Earlier, we considered a mechanism of loose fixing of edge lengths due to the functional integral measure arising from integration over connection in the functional integral for the connection representation of the Regge action. The length scale depends on a free dimensionless parameter that determines the final functional measure. For this parameter and the length scale large in Planck units, the resulting effective action is close to the Regge action. Earlier, we considered the Regge action in terms of affine connection matrices as functions of the metric inside the 4-simplices and found that it is a finite-difference form of the Hilbert–Einstein action in the leading order over metric variations between the 4-simplices. Now we take the (continuum) Schwarzschild problem in the form where spherical symmetry is not set a priori and arises just in the solution, take the finite-difference form of the corresponding equations and get the metric (in fact, in the Lemaitre or Painlevé–Gullstrand like frame), which is nonsingular at the origin, just as the Newtonian gravitational potential, obeying the difference Poisson equation with a point source, is cutoff at the elementary length and is finite at the source.
THE SPILLOVER EFFECTS OF THE RE-IMPOSED UNITED STATES SANCTIONS ON IRAN ON MENA, THE PRC, RUSSIA, AND TURKEY
Authors: PELZMAN JOSEPH 
Published: May 2020

Iran has faced US sanctions in one form or another since its invasion of the US Embassy in Iran in 1979. The 2007-08 period marked the initiation of heightened international sanctions on Iran imposed by the UN Security Council in reaction to Iran’s nuclear program. These sanctions were tightened in 2010, when the UN Security Council, the US Congress, and the European Union all implemented separate sets of sanctions targeting either the Iranian nuclear program or the energy and banking sectors. Under the Obama Administration the Joint Plan of Action (JPOA) was signed in late 2013 and within months the United States and the EU took steps to waive specific sanctions. In 2015 the Joint Comprehensive Plan of Action (JCPOA) was signed, which lifted nuclear-related sanctions by the UN, EU and US. The Trump Administration on May 8, 2018 announced the US withdrawal from the JCPOA and directed federal agencies to begin to take steps to re-impose the sanctions established under U.S. law that were lifted or waived in order for the United States to meet its commitments in the JCPOA. On November 5, 2018, all pre-JCPOA - U.S. sanctions on foreign firms that conduct transactions in all of Iran’s core economic sectors, including energy, banking, shipping, and manufacturing, went back into effect. These include sanctions on “petroleum-related transactions” and transactions by foreign banks with Iran’s Central Bank. In addition,700 Iranian and third country entities have again been designated by the United States as sanctioned entities, meaning that foreign firms that transact business with these entities could face virtual exclusion from the U.S. economy. With the re-imposition of sanctions on Iran, in 2018, the US finds itself as a lone player in a world where the EU, the PRC, Russia and a group of MENA countries have no intentions to comply with these re-imposed sanctions. The purpose of this paper, consequently, is to assess the spillover effects which can be expected to result from the US re-imposition of Iran sanctions on relevant MENA countries, the PRC, Russia and Turkey.