bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Biomimetic Glue Protein Modulates Hepatic Gene Expression
Authors: Lu Yi , Dai Wentao , Huang Jianhua , Chen Xuexin , Yao Yuan 
Published: January 2021

AbstractGlue protein as secretion from fruit fly larva plays a significant role in metamorphosis as cementing material for pupation sites. However, the biochemical composition of this macromolecule remains obscure. This study takes the advantage of high‐resolution proteomic analysis to unveil the protein compositions. A glue protein group is identified as chitin‐binding motifs by bioinformatic analysis. Computational modeling analysis of representative proteins illustrates the binding site between protein and chitin. A biosynthetic approach is used to fabricate a glue protein by a modified Escherichia coli recombinant system. The as‐biosynthesized biomimetic glue protein is applied as an extracellular matrix to investigate its biocompatibility and functionality. It is found that the purified recombinant protein shows enhanced performance to cellular viability. This finding provides a potential biomacromolecule candidate as an extracellular matrix for cell culture.
Multifunctionality in Polymer Networks by Dynamic of Coordination Bonds
Authors: Zhang Pengfei , Rešetič Andraž , Behl Marc , Lendlein Andreas 
Published: January 2021

AbstractThe need for multifunctional materials is driven by emerging technologies and innovations, such as in the field of soft robotics and tactile or haptic systems, where minimizing the number of operational components is not only desirable, but can also be essential for realizing such devices. This study report on designing a multifunctional soft polymer material that can address a number of operating requirements such as solvent resistance, reshaping ability, self‐healing capability, fluorescence stimuli‐responsivity, and anisotropic structural functions. The numerous functional abilities are associated to rhodium(I)–phosphine coordination bonds, which in a polymer network act with their dynamic and non‐covalently bonded nature as multifunctional crosslinks. Reversible aggregation of coordination bonds leads to changes in fluorescence emission intensity that responds to chemical or mechanical stimuli. The fast dynamics and diffusion of rhodium–phosphine ions across and through contacting areas of the material provide for reshaping and self‐healing abilities that can be further exploited for assembly of multiple pieces into complex forms, all without any loss to material‐sensing capabilities.
Semiparametric MEWMA for Phase II profile monitoring
Authors: Nassar Sara H. , Abdel‐Salam Abdel‐Salam G. 
Published: January 2021

AbstractA control chart is one of the statistical process techniques that is used to monitor different processes. Some processes are characterized by functions or profiles, and a profile is a functional relationship between the dependent and independent variable(s) used to monitor the quality of the process. Several research studies were conducted on linear profiling where only fixed effects are considered. However, in this research, we focus on random effects as they represent the differences between profiles and thus are more proper for interpretation. Two approaches are proposed in this study for Phase II profile monitoring; the first approach is the nonparametric via residuals and the second is the semiparametric approach, where this technique combines the parametric estimates with a portion of the nonparametric estimates to the residuals. Usually, parametric estimations lead to biased estimates when the model is misspecified, whereas nonparametric estimates may give high variances, and thus semiparametric estimates are preferred. New nonparametric and semiparametric multivariate exponential weighted moving average (MEWMA) control charts are introduced and their performances compared to the parametric approach for different samples and shift sizes, and the correlation between and within profiles was considered. The average run length (ARL) and average time to signal (ATS) criteria are used for choosing the best approach. Simulation studies and real datasets were utilized for comparing the performance of the proposed MEWMA charts.
Transition Metal‐Free Synthesis of Carbo‐ and Heterocycles via Reaction of Alkynes with Organylchalcogenides
Authors: Zeni Gilson , Godoi Benhur , Jurinic Carla K. , Belladona Andrei L. , Schumacher Ricardo F. 
Published: January 2021

AbstractThis manuscript intends to overview the most recent advances in the synthesis of carbo‐ and heterocycles through reactions of alkynes with organyl chalcogenides (S, Se, Te) under metal‐free conditions. Firstly, the use of electrophilic chalcogenyl halides as a selective reagent for alkyne carbon‐carbon triple bond activation will be presented. After that, radical cyclization protocols employing electrochemical oxidative conditions, light‐induced photoredox catalysis, or mild oxidants with direct chalcogenyl group installation will be discussed accompanied by the proposed mechanisms.
Comparison in the performance of magnetic field–induced MBBR‐coupled with advanced oxidation processes for textile effluent treatment with cost estimation
Authors: K. J. Sosamony , P. A. Soloman 
Published: January 2021

AbstractDirect biological treatment of textile effluent is not amicable as its biodegradability index (BI) is low. This study has focused on the feasibility of improving the biodegradability by pretreating the effluent using advanced oxidation processes, namely homogeneous solar photo‐Fenton (HSPF) and advanced solar photo‐Fenton (ASPF) processes and subsequent treatment through moving bed biofilm reactor (MBBR) exposed with a magnetic field. In the ASPF process, biosynthesized nano zero‐valent iron in place of Fe2+ has been used. Enhancement in biodegradability after pretreatments has been confirmed by the BI, kinetic coefficients, and toxicity test. The satisfactory physical state of the sludge has been ensured by an improved sludge volume index of the pretreated effluents. The effluents after pretreatments have been undergone treatment through moving bed biofilm reactor (MBBR) after inducing the magnetic field and found that the treated effluent can be disposed of either into irrigation water or into inland waters conforming to the standards of effluent parameters. Carrier materials inoculated with predominant bacteria present in the textile sludge identified by the 16S rRNA method have been used in the MBBR. The parameters affecting the photo‐Fenton and MBBR treatment have been optimized using the Box–Behnken design in response surface methodology. The cost of the two integrated processes (HSPF+MBBR and ASPF+MBBR) has also been compared and it is found that the ASPF–MBBR integrated process proved slightly less expensive.
Fate of the Left Pulmonary Artery and Thoracic Aorta After Transcatheter Patent Ductus Arteriosus Closure in Low Birth Weight Premature Infants
Authors: Markush Dor , Tsing Jennifer C. , Gupta Surbhi , Berndsen Nicole C. , Radville Geena , Garg Ruchira , Zahn Evan M. , Almeida-Jones Myriam 
Published: January 2021

AbstractTranscatheter patent ductus arteriosus closure (TCPC) is an emerging treatment for low birth weight extremely premature neonates (EPNs). Left pulmonary artery (LPA) and descending aorta (DAO) obstruction are described device-related complications, however, data on mid- and long-term vascular outcomes are lacking. A retrospective analysis of EPNs who underwent successful TCPC at our institution from 03/2013 to 12/2018 was performed. Two-dimensional echocardiography and spectral Doppler velocities from various time points before and after TCPC were used to identify LPA and DAO flow disturbances. A total of 44 EPNs underwent successful TCPC at a median (range) procedural weight of 1150 g (755–2500 g). Thirty-two (73%) patients were closed with the AVP II and 12 (27%) with the Amplatzer Piccolo device. LPA and DAO velocities on average remained within normal limits and improved spontaneously in long-term follow up (26.1 months, range 1–75 months). One patient, who had concerning LPA flow characteristics immediately after device implant (peak velocity 2.6 m/s) developed progressive LPA stenosis requiring stent placement 3 months post-procedure. In the remaining infants, including 7 (16%) who developed LPA and 3 (7%) who developed DAO flow disturbances (range 2–2.4 m/s), all had progressive normalization of flow velocities over time. TCPC can be performed safely in EPNs with a low incidence of LPA and DAO obstruction. In the absence of significant progressive vascular obstruction in the early post-procedure period, mild increases in LPA and DAO flow velocities tend to improve spontaneously and normalize in long-term follow-up.
NUIST ESM v3 Data Submission to CMIP6
Authors: Cao Jian , Ma Libin , Liu Fei , Chai Jing , Zhao Haikun , He Qiong , Wang Bo , Bao Yan , Li Juan , Yang Young-min , Deng Hua , Wang Bin 
Published: January 2021

AbstractThis paper introduces the experimental designs and outputs of the Diagnostic, Evaluation and Characterization of Klima (DECK), historical, Scenario Model Intercomparison Project (MIP), and Paleoclimate MIP (PMIP) experiments from the Nanjing University of Information Science and Technology Earth System Model version 3 (NESM3). Results show that NESM3 reasonably simulates the modern climate and the major internal modes of climate variability. In the Scenario MIP experiment, changes in the projected surface air temperature (SAT) show robust “Northern Hemisphere (NH) warmer than Southern Hemisphere (SH)” and “land warmer than ocean” patterns, as well as an El Niño-like warming over the tropical Pacific. Changes in the projected precipitation exhibit “NH wetter than SH” and “eastern hemisphere gets wetter and western hemisphere gets drier” patterns over the tropics. These precipitation patterns are driven by circulation changes owing to the inhomogeneous warming patterns. Two PMIP experiments show enlarged seasonal cycles of SAT and precipitation over the NH due to the seasonal redistribution of solar radiation. Changes in the climatological mean SAT, precipitation, and ENSO amplitudes are consistent with the results from PMIP4 models. The NESM3 outputs are available on the Earth System Grid Federation nodes for data users.
Lungenmanifestationen bei adulten rheumatischen Erkrankungen
Authors: Ewig S. , Bollow M. 
Published: January 2021

Zusammenfassung
Hintergrund
Rheumatologische Erkrankungen gehen häufig mit einer Lungenbeteiligung einher. Alle anatomischen Strukturen der Lunge können dabei betroffen sein. Für Lungengerüsterkrankungen gilt ein System der Muster, mit denen sie sich in der HR-CT der Lunge präsentieren. Rheumatologische Erkrankungen können unterschiedliche HR-CT-Muster aufweisen.

Ziel der Arbeit
Systematische Beschreibung der Lungenbefallsmuster rheumatologischer Erkrankungen.

Material und Methoden
Narratives Review auf dem Boden der aktuellen Literatur zum Thema aus rheumatologischer, pneumologischer und radiologischer Sicht.

Ergebnisse
Eine Lungenbeteiligung ist häufig und prognostisch relevant. Die Zusammenfassung der Lungenbefallsmuster zeigt bei entzündlich rheumatologischen Erkrankungen eine hohe Variabilität hinsichtlich der bevorzugt befallenen anatomischen Strukturen als auch der bevorzugten Muster interstitieller Manifestationen. Prognostische Implikationen und wesentliche diagnostische Befunde werden synoptisch dargestellt.

Diskussion
Jede hier aufgeführte rheumatologische Erkrankung kann mit einer Lungenbeteiligung einhergehen. Eine systematische diagnostische Evaluation ist daher bei Erstdiagnose und im Verlauf immer angezeigt. Neben Klinik und Lungenfunktion ist die HR-CT der Lunge für die Diagnostik entscheidend.
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis
Authors: Mehta Arpan R. , Gregory Jenna M. , Dando Owen , Carter Roderick N. , Burr Karen , Nanda Jyoti , Story David , McDade Karina , Smith Colin , Morton Nicholas M. , Mahad Don J. , Hardingham Giles E. , Chandran Siddharthan , Selvaraj Bhuvaneish T. 
Published: January 2021

AbstractAxonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron (MN), has an axon extending up to a metre long. The maintenance of axonal function is a highly energy-demanding process, raising the question of whether MN cellular energetics is perturbed in ALS, and whether its recovery promotes axonal rescue. To address this, we undertook cellular and molecular interrogation of multiple patient-derived induced pluripotent stem cell lines and patient autopsy samples harbouring the most common ALS causing mutation, C9orf72. Using paired mutant and isogenic expansion-corrected controls, we show that C9orf72 MNs have shorter axons, impaired fast axonal transport of mitochondrial cargo, and altered mitochondrial bioenergetic function. RNAseq revealed reduced gene expression of mitochondrially encoded electron transport chain transcripts, with neuropathological analysis of C9orf72-ALS post-mortem tissue importantly confirming selective dysregulation of the mitochondrially encoded transcripts in ventral horn spinal MNs, but not in corresponding dorsal horn sensory neurons, with findings reflected at the protein level. Mitochondrial DNA copy number was unaltered, both in vitro and in human post-mortem tissue. Genetic manipulation of mitochondrial biogenesis in C9orf72 MNs corrected the bioenergetic deficit and also rescued the axonal length and transport phenotypes. Collectively, our data show that loss of mitochondrial function is a key mediator of axonal dysfunction in C9orf72-ALS, and that boosting MN bioenergetics is sufficient to restore axonal homeostasis, opening new potential therapeutic strategies for ALS that target mitochondrial function.
Optimisation and evaluation of the random forest model in the efficacy prediction of chemoradiotherapy for advanced cervical cancer based on radiomics signature from high-resolution T2 weighted images
Authors: Liu Defeng , Zhang Xiaohang , Zheng Tao , Shi Qinglei , Cui Yujie , Wang Yongji , Liu Lanxiang 
Published: January 2021

Abstract
Purpose
Our objective was to establish a random forest model and to evaluate its predictive capability of the treatment effect of neoadjuvant chemotherapy–radiation therapy.

Methods
This retrospective study included 82 patients with locally advanced cervical cancer who underwent scanning from March 2013 to May 2018. The random forest model was established and optimised based on the open source toolkit scikit-learn. Byoptimising of the number of decision trees in the random forest, the criteria for selecting the final partition index and the minimum number of samples partitioned by each node, the performance of random forest in the prediction of the treatment effect of neoadjuvant chemotherapy–radiation therapy on advanced cervical cancer (> IIb) was evaluated.

Results
The number of decision trees in the random forests influenced the model performance. When the number of decision trees was set to 10, 25, 40, 55, 70, 85 and 100, the performance of random forest model exhibited an increasing trend first and then a decreasing one. The criteria for the selection of final partition index showed significant effects on the generation of decision trees. The Gini index demonstrated a better effect compared with information gain index. The area under the receiver operating curve for Gini index attained a value of 0.917.

Conclusion
The random forest model showed potential in predicting the treatment effect of neoadjuvant chemotherapy–radiation therapy based on high-resolution T2WIs for advanced cervical cancer (> IIb).
Procedural virtual reality simulation training for robotic surgery: a randomised controlled trial
Authors: Raison Nicholas , Harrison Patrick , Abe Takashige , Aydin Abdullatif , Ahmed Kamran , Dasgupta Prokar 
Published: January 2021

Abstract
Background
Virtual reality (VR) training is widely used for surgical training, supported by comprehensive, high-quality validation. Technological advances have enabled the development of procedural-based VR training. This study assesses the effectiveness of procedural VR compared to basic skills VR in minimally invasive surgery.

Methods
26 novice participants were randomised to either procedural VR (n = 13) or basic VR simulation (n = 13). Both cohorts completed a structured training programme. Simulator metric data were used to plot learning curves. All participants then performed parts of a robotic radical prostatectomy (RARP) on a fresh frozen cadaver. Performances were compared against a cohort of 9 control participants without any training experience. Performances were video recorded and assessed blindly using GEARS post hoc.

Results
Learning curve analysis demonstrated improvements in technical skill for both training modalities although procedural training was associated with greater training effects.
Any VR training resulted in significantly higher GEARS scores than no training (GEARS score 11.3 ± 0.58 vs. 8.8 ± 2.9, p = 0.002). Procedural VR training was found to be more effective than both basic VR training and no training (GEARS 11.9 ± 2.9 vs. 10.7 ± 2.8 vs. 8.8 ± 1.4, respectively, p = 0.03).

Conclusions
This trial has shown that a structured programme of procedural VR simulation is effective for robotic training with technical skills successfully transferred to a clinical task in cadavers. Further work to evaluate the role of procedural-based VR for more advanced surgical skills training is required.
Experimental verification of the characteristic behaviors in passive dynamic walking
Authors: Iribe Masatsugu , Hirouji Ryoichi , Ura Daisuke , Osuka Koichi , Kinugasa Tetsuya 
Published: January 2021

AbstractIt is well known that passive dynamic walking shows chaotic behavior owing to changes in the environment. In addition, when the environment changes continuously during walking, passive dynamic walking shows “adaptive behaviors” in which the stride angle changes itself in an attempt to keep walking. These behaviors are very interesting and useful for the legged robot design. However, the studies on passive dynamic walking are preceded only by numerical simulations. For this reason, it is very important to confirm, by actual experiments, whether these characteristic behaviors appear. In this paper, we verify the existence of these behaviors by several actual experiments.
Non-Pregnant and Pregnant Women’s Femininity Preferences in Male Faces: Tests Based on Within- and Between-Sex Sexual Dimorphism Facial Manipulations
Authors: Wen Fangfang , Zuo Bin , Wang Yang , Ma Shuhan , Song Shijie , Zhang Hongxia 
Published: January 2021

AbstractPast research on women’s preferences for male facial masculinity in Western cultures has produced inconsistent results. Some inconsistency may be related to the use of different facial stimulus manipulations (e.g., between-sex sexual dimorphic facial manipulation or within-sex sexual dimorphic facial manipulation) that do not perfectly avoid non-facial cues, and pregnancy status may also influence women’s face preferences. We therefore recruited pregnant and nonpregnant Chinese women and manipulated the sexual dimorphism of male facial stimuli to explore the influences of manipulation methods, non-facial cues, and pregnancy status on face preferences. Results showed that: (1) in contrast with a general masculinity preference observed in Western cultures, both pregnant and nonpregnant Chinese women preferred feminized and neutral male faces generally; (2) pregnant women’s preference for feminized male faces was stable across manipulation methods, while nonpregnant women preferred feminized male faces except under between-sex sexual dimorphism manipulation; and (3) manipulation methods, rather than non-facial cues, influenced participants’ face preferences. Specifically, women showed the strongest preferences for femininity when face stimuli were manipulated by within-sex sexual dimorphic facial manipulation, followed by unmanipulated faces and between-sex sexual dimorphic facial manipulation. This effect was stronger for nonpregnant women in the unmanipulated condition and for pregnant women in the between-sex sexual dimorphic facial manipulation. This research provides empirical evidence of women’s preferences for sexual dimorphism in male faces in a non-Western culture, as well as the effects of facial manipulation methods, pregnancy status, and the interactions between these factors.
The Inhibitory Effect of Political Conservatism on Consumption: The Case of Fair Trade
Authors: Usslepp Thomas , Awanis Sandra , Hogg Margaret K , Daryanto Ahmad 
Published: January 2021

AbstractFair trade has been researched extensively. However, our understanding of why consumers might be reluctant to purchase fair trade goods, and the associated potential barriers to the wider adoption of fair trade products, is incomplete. Based on data from 409 USA participants, our study demonstrates some of the psychological processes that underlie the rejection of fair trade products by conservatives. Our findings show that political conservatism affects fair trade perspective-taking and fair trade identity, and these latter two subsequently affect fair trade purchase intention. The decrease in fair trade perspective-taking and fair trade identity are two psychological features that potentially shield conservatives from the appeals of fair trade products. We extend prior research on the effects of political ideology on consumption not only by demonstrating the predisposition of highly conservative consumers towards prosocial consumption, but also by showing the internal functioning of the conservative decision-making process. We further demonstrate that the effect of conservatism on fair trade purchase deliberation is moderated by age and income. Age reduces the negative effect of conservatism on fair trade perspective-taking, whereas income heightens the negative effect of conservatism on fair trade perspective-taking. Our results suggest that fair trade initiatives can target the conservative consumer segment in high-income countries with a greater chance of success when applying marketing strategies that make perspective-taking redundant and that aim at younger consumers with lower incomes.