bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture of fascia points to relieve hand spasm after stroke: a study protocol for a multicenter randomized controlled trial
Authors: zhang zengqiao , Feng Wei , Li Kun-Peng , He Jing , Jiang Li-Ming , Wang Wu , Hu Xiao-Shen 
Published: December 2019

Abstract
Background: The loss of life ability of patients after stroke is mostly caused by the dysfunction of upper limbs, especially hands. Hand functional exercise is the premise of alleviating hand dysfunction, and the relief of hand spasm is the basis of timely and effective hand functional exercise. Previous clinical observation showed that fascial point needling could effectively alleviate hand spasm immediately after stroke, but further evidence from large sample studies is needed. The overall objective of this trial is to further evaluate the clinical efficacy of fascial point acupuncture on hand spasm after stroke. Methods/design: This multicenter randomized controlled trial will compare the efficacy of fascial point acupuncture versus sham acupuncture and routine rehabilitation therapy in stroke patients with hand spasm. Patients will be randomized to undergo either the fascial point acupuncture or the sham acupuncture or the control (routine rehabilitation therapy). We will recruit 210 stroke inpatients who meet the trial criteria and observe the remission of hand spasm and improvement of limb function after 4 weeks of intervention. The first evaluation indexes are the remission of hand spasm and the duration of spasm remission. The second evaluation indexes are the hand function of affected limbs and the ability of daily living. When the accumulative total number of cases included reaches 120, a mid-term analysis will be conducted to determine any evidence that experimental intervention does have an advantage. Discussion: Our aim is to evaluate the efficacy of fascial point acupuncture in relieving hand spasm after stroke. The results will provide more evidences for the clinical application of this therapy in the future. Trial registration: The trial has been registered at the Chinese Clinical Trial Registry（ChiCTR）on April 9, 2019. Registration number: ChiCTR1900022379 Keywords: Fascia points, Acupuncture, Spasm, Stroke
Loosening and revision rates after total shoulder arthroplasty: a systematic review of cemented all-polyethylene glenoid and design of the modern metal-backed glenoid
Authors: Kim Dong Min , Aldeghaither Mohammed , Alabdullatif Fahad , Shin Myung Jin , Kholinne Erica , Kim Hyojune , Jeon In-Ho , Koh Kyoung-Hwan 
Published: December 2019

Abstract
Background: Modern designs of metal-backed glenoids (MBG) have been devised to overcome flaws such as loosening and a high failure rate.This review aimed to compare rates of complications and revision surgeries between the modern metal-backed glenoid (MBG) and the cemented polyethylene glenoid (PEG).Methods: Literature search was carried out using PubMed, Cochrane Library, EMBASE, and Google Scholar using MeSH terms and natural keywords. A total of 1186 articles were screened. We descriptively analyzed numerical data between the groups and statistically analyzed the categorical data, such as the presence of radiolucent line, loosening, and revision surgery (failure). Articles were divided into 3 groups based on follow-up duration: short-term < 36 months, midterm 36–72 months, and long-term > 72 months.Results: This study included 35 articles (3769 shoulders); 25 on cemented PEG and ten on the modern MBG. Mean age was 66.4 (21–93) and 66.5 years (31–88). The mean duration of follow-up was 73.1 (12–211) and 56.1 months (24–100). Overall, the rate of the radiolucent line was 354/1302 (27%) and 47/282 (17%), the loosening rate was 465/3185 (15 %) and 22/449 (5%), and the failure rate was 189/3316 (6%) and 11/457 (2%), for PEG and MBG, respectively. The results of short- and mid-term FU studies showed lower rates of radiolucency and loosening in the cemented PEG group, but there was no significant difference in failure rate (P=0.754 and 0.829, respectively). In long-term FU, MBG was better in terms of loosening (P <0.001) and failure rates (P = 0.006).Conclusions: The modern MBG component, especially TM glenoid, seems to be a promising alternative to cemented PEGs, based on subgroup revision rates according to the follow-up duration and overall results of ROM and clinical scores. All polyethylene glenoids tend to increase loosening and failure over time. The modern MBG seems to have no difference in failure, at least in the short- and mid-term compared to the cemented PEG. More long-term follow-up studies on modern MBG should be ultimately conducted.
Playing sport injured is associated with osteoarthritis, joint pain and worse health related quality of life: A cross sectional study
Authors: Bullock Garrett Scott , Collins Gary S , Peirce Nick , Arden Nigel K , Filbay Stephanie R 
Published: December 2019

Abstract
Background: Sports participants are faced with the decision to continue or cease play when injured. The implications of playing sport while injured on joint health and health-related quality of life (HRQoL) has not been investigated. The purpose of this study was to investigate the relationship between having played sport while injured and HRQoL, osteoarthritis, and persistent joint pain; and compare findings in elite and recreational athletes. Methods: The Cricket Health and Wellbeing Study cohort was used for this study. Inclusion criteria were: age ≥18 years, played ≥1 cricket season. Questionnaire data collected included a history of playing sport injured, SF-8 (physical (PCS) and mental (MCS) component scores), physician-diagnosed osteoarthritis, and persistent joint pain (most days of the last month). Multivariable linear regressions and logistic regressions were performed. Continuous covariates were handled using fractional polynomials. Models were adjusted for age, sex, cricket-seasons played, playing status, joint injury, and orthopaedic surgery. All participants (n=2,233) were included in HRQoL analyses, only participants aged ≥30 years (n=2,071) were included in osteoarthritis/pain analyses. Results: Of the 2,233 current and former cricketers (mean age: 51.7 SD 14.7, played 30 IQR 24 cricket seasons, 60% were current cricketers, 62% played recreationally; median PCS: 51.4 IQR 9.0; MCS: 54.3 IQR 8.6) 1719 (77%) had played sport while injured. People who had played sport injured reported worse adjusted PCS (Effect(95% CI): -1.78(-2.62, -0.93) and MCS (-1.40(-2.25, -0.54), had greater odds of osteoarthritis (adjusted OR(95% CI): 1.86(1.39, 2.51) and persistent joint pain (2.34(1.85, 2.96)), compared to people who had not played sport injured. Similar relationships were observed regarding PCS, osteoarthritis and pain in elite and recreational subgroups. Playing injured was only related to worse MCS scores for elite cricketers (-2.07(-3.52, -0.63)); no relationship was observed in recreational cricketers (-0.70(-1.79, 0.39)). Conclusion: Athletes that had played sport injured had impaired HRQoL, increased odds of osteoarthritis and persistent joint pain, compared to those who had not played sport injured. Playing sport injured was only related to impaired mental-components of HRQoL in elite athletes. Recreational and elite athletes should be informed of the potential long-term health implications of playing sport while injured.
A New Modification of Bosworth’s Technique to Repair Infectious Achilles Tendon Rupture
Authors: Wu Qipeng , Xiong Yuan , Fang Zhenhua , Wang Junwen , Liu Guohui , Lu Lin 
Published: December 2019

Abstract
Background The aim of this study was to assess radiographic and clinical outcomes of a new modified approach on the basis of Bosworth’s technique in the treatment of infectious Achilles tendon rupture (IATR). Materials and methods 15 patients (9 males and 6 females; 15 feet; average age of 38.3 years) were included in the study. After infection, the wounds were transferred to our department for treatment (Figure 1).Radiographic and clinical outcome in terms of the American Orthopaedic Foot&Ankle Society score (AOFAS), the Victorian institute of sports assessment Achilles (VISA-A), and the Achilles tendon total rupture score (ATRS) were investigated at 6 months, 12 months, and 24 months postoperatively. Results Preoperative AOFAS, VISA-A, and ATRS showed statistically significant improvement (p≤0.05) from35.03±6.81 (25-45), 21.04±8.17 (5-45), and 20.08±8.93 (6-55) to 90.04±5.32 (82-97), 95.11±3.09 (79-99), and 96.34±3.61 (89-97) at the last follow-up, respectively. All patients could lift heel on one foot and return to work at 12 to 16 weeks after operation (average 14.2 weeks). Overall, No complications such as infection, skin necrosis, sural nerve injury, deep vein thrombosis, and re-rupture of Achilles tendon occurred at last follow-up. Conclusion The new modified approach of Bosworth’s technique provided powerful curative efficacy of infectious Achilles tendon rupture, without severe complications in terms of infection, skin necrosis, sural nerve injury, deep vein thrombosis, and re-rupture of Achilles tendon. Level of Evidence: Level IV, case series.
Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression
Authors: Liu Qing , Yang Chaogang , Wang Shuyi , Shi Dongdong , Wei Chen , Song Jialin , Lin Xiaobin , Dou Rongzhang , Bai Jian , Xiang Zhenxian , Huang Sihao , Liu Keshu , Xiong Bin 
Published: December 2019

Abstract
Background: Tumor-associated macrophages (TAMs) in the tumor microenvironment influence tumor initiation, invasion and metastasis. Several studies have shown that Wnt5a is mainly expressed in the tumor stroma, especially in TAMs. However, whether Wnt5a regulates the polarization and biological function of TAMs in colorectal cancer (CRC) is incompletely understood. Methods: Immunofluorescence staining was performed to detect CD68 and Wnt5a expression in colorectal tissues from patients (63 CRC specimens VS 20 normal tissues). RT-qPCR, flow cytometry, ELISA and inhibitors were carried out to explore the role of Wnt5a in the polarization of TAMs. Clone formation and transwell assays were performed to determine the effects of Wnt5a–treated macrophages on tumor proliferation, migration and invasion in vitro. Finally, a xenograft model was applied to confirm the effects of Wnt5a+ TAMs on CRC tumorigenesis. Results: We found that high Wnt5a+CD68+/CD68+ TAMs ratio was significantly associated with poor prognosis in CRC patients and Wnt5a+ TAM was an M2-like TAM subtype. Subsequently, we found that Wnt5a induced macrophages to secrete IL-10, which then acted as an autocrine cytokine to induce M2 polarization of these macrophages. IL-10 neutralizing antibody completely reversed the pro-M2 effect of Wnt5a. Mechanistically, the CaKMII-ERK1/2-STAT3 pathway was required for Wnt5a-mediated IL-10 expression in macrophages. Furthermore, Wnt5a-induced M2 macrophages promoted CRC cells proliferation, migration and invasion; knockdown of Wnt5a in TAMs significantly impaired the pro-tumor functions of TAMs. Conclusions: Our data indicate that Wnt5a could induce M2 polarization of TAMs by regulating CaKMII-ERK1/2-STAT3 pathway–mediated IL-10 secretion, ultimately promoting tumor growth and metastasis of CRC.
Can the DREEM scale be adapted to the medical simulation environment?
Authors: Mamcarz Izabela , Torres Anna , Mamcarz Piotr , Torres Kamil 
Published: December 2019

Abstract
Background The environment of medical simulation is a specific educational environment for teaching medicine. Medical universities are obliged to ensure appropriate conditions for conducting classes in medical simulation. In order to improve the quality of courses in simulation, it is necessary to get to know the educational environment and the medical simulation environment. It will be possible thanks to appropriately selected methods, which include important variables shaping these environments.MethodsAmong 312 medical students who had classes in medical simulation, the DREEM method (Roff et al.) and the QuESST method (Mamcarz et al.) were applied.Results The process of adapting the DREEM tool to Polish conditions and the construction stages of the QuESST tool were presented. The overall results of the QuESST and DREEM questionnaires correlated significantly. Also the overall result of QuESST correlated significantly with the results of individual DREEM scales.Conclusions The presented tools may be helpful in determining the educational conditions and conditions of medical simulation as a specific educational environment for teaching and learning medicine.
Challenges in the cultural adaptation of the German Myeloma Patient Outcome Scale (MyPOS): an outcome measure to support routine symptom assessment in myeloma care
Authors: Gerlach Christina , Taylor Kathy , Ferner Marion , Munder Markus , Weber Martin , Ramsenthaler Christina 
Published: December 2019

Abstract
Background Patients with multiple myeloma report more problems with quality of life (QoL) than other haematological malignancies over the course of their incurable illness. The patient-centred Myeloma Patient Outcome Scale (MyPOS) was developed to assess and monitor symptoms and supportive care factors in routine care. Our aim was to translate and culturally adapt the outcome measure to the German context, and to explore its face and content validity. Methods Translation and cultural adaptation following established guidelines used an exploratory, sequential mixed method study design. Steps included: (1) forward translation to German; (2) backward translation to English; (3) expert review; (4) focus groups with the target population (patients, family members, health care professionals) to achieve conceptual equivalence; (5) cognitive interviews using Tourangeau’s model with think-aloud technique to evaluate comprehension and acceptability; (6) final review. Results were analysed using thematic analysis. Results Cultural and linguistic differences were noted between the German and English original version. The focus groups (n = 11) and cognitive interviews (n = 9) both highlighted the need for adapting individual items and their answer options to the German health care context. Greater individuality regarding need for information with the right to not be informed was elaborated by patients. While the comprehensive nature of the tool was appreciated, item wording regarding satisfaction with health care was deemed not appropriate in the German context. For implementation into routine care, careful handling of data was addressed as a barrier, whereas the MyPOS itself was perceived as a facilitator/prompt for a patient-centred discussion of QoL issues. Conclusion With adaptations to answer options and certain items, the German version of the MyPOS can help monitor symptoms and problems afflicting myeloma patients over the course of the disease trajectory. It can help promote a model of comprehensive supportive and patient-centred care for these patients.
Genome-wide analysis of OVATE family proteins in cucumber (Cucumis sativus L.)
Authors: Han Lijie , Song Xiaofei , Wang Zhongyi , Liu Xiaofeng , Yan Liying , Zhou Zhaoyang , Zhang Xiaolan 
Published: December 2019

Abstract
Background: OVATE family proteins (OFPs) are plant-specific proteins with the conserved OVATE domain that regulating plant growth and development. Although these OFPs have been studied in several species, the biological functions of this OFP gene family remain largely unknown in cucumber (Cucumis sativus L.).
Results: In this study, we identified 19 CsOFPs in cucumber. This CsOFPs are distributed on seven chromosomes and can be divided into four subgroups. Most CsOFP genes are expressed in reproductive organs although have different expression patterns. Cis-elements analysis showed that there are six kinds of hormone response elements in CsOFPs and exogenous gibberellin treatment leads to a ‘first increase then decrease’ expression pattern of CsOFP7, CsOFP11 and CsOFP12. Ectopic expression of CsOFP11 in Arabidopsis resulted in shorter and blunt siliques.
Conclusions: Together, these results indicated that CsOFPs may play important roles in cucumber fruit development.
Factors influencing cognitive reactivity among young adults at high risk for depression in China: a cross-sectional study
Authors: Huang Fei Fei , Wen Zhi Peng , Li Qi , Chen Bin , Weng Wen Jie 
Published: December 2019

Abstract
BackgroundUnderstanding the factors influencing cognitive reactivity (CR) may help identify individuals at risk for first episode depression and relapse, and facilitate routine access to preventative treatments. However, few studies have examined CR to depression in Asian countries. This study was performed to ascertain the current status of CR among Chinese young adults and explore the factors that influence their CR. MethodsA national cross-sectional online study using convenience sampling was conducted among 1637 healthy young adults in China (96.29%). ResultsThe mean CR score was 1.73±0.64. Binary logistic regression showed that a low level of CR was associated with the following factors: high self-compassion, high social support, high resilience, high monthly household income, and living in a rural area, with odds ratios (ORs) ranging from 0.14 to 0.70. Young adults in full-time employment, experiencing poor sleep, with high neuroticism, who reported frequent sad mood, and who had a high intensity of negative life events had increased CR to depression, with ORs ranging from 1.18 to 6.66. The prediction probability of these factors was 75.40%. Any causal relationships among the influencing factors and CR cannot be established. ConclusionsThe self-reported CR levels among Chinese young adults were moderate. Enhancing self-compassion, resilience, and social support for young adults and reducing negative life events, neuroticism, and poor sleep may facilitate reducing CR. These findings may help healthcare providers or researchers determine how to cultivate and improve the CR of young adults by establishing documented policies and/or improving intervention efficacies.
Identification of novel rice blast resistance alleles through sequence-based allele mining
Authors: Zhou Ying , Lei Fang , Wang Qiong , He Weicong , Bin Yuan , Yuan Wenya 
Published: December 2019

Abstract
Background: As rice ( Oryza sativa ) is the staple food of more than half the world’s population, rice production contributes greatly to global food security. Rice blast caused by the fungus M agnaporthe oryzae is a devastating fungal disease of rice, affecting yield and grain quality and resulting in substantial annual economic losses. Because the fungus evolves rapidly,, resistance conferred by most of the single blast race resistance genes is often broken after a few years of intensive agricultural use. Effective resistance breeding in rice therefore requires continual enrichment of the reservoir of resistance genes and alleles. Seed banks represent a rich source of genetic diversity; however, they have not been extensively used to identify novel genes and alleles. Results: We carried out a large-scale screen for novel blast resistance alleles in 1883 rice varieties from major rice producing areas across China. Of these, 107 varieties showed at least moderate resistance to natural infection by rice blast at rice blast nurseries in Enshi and Yichang, Hubei Province. Using sequence-based allele mining to amplify and clone the allelic variants of major rice blast resistance genes at the Pi2/9/gm/zt locus of chromosome 6 from the 107 blast-resistant varieties, we identified 13 novel blast resistance alleles. We then used controlled infections to assess the resistance of rice varieties carrying the novel alleles to 34 single rice blast isolates from Hubei, Guangdong, Jiangsu, Hunan, Jangxi, Sichuan, Heilongjiang, and Fujin Provinces. The varieties identified as being resistant in the nursery trials showed varied disease responses when infected with the single blast isolates, suggesting that the novel Pi2/9/gm/zt alleles vary in their blast resistance spectra. Some of the newly identified alleles have unique single nucleotide polymorphisms (SNPs), insertions, or deletions, in addition to polymorphic residues that are shared between the different alleles. Conclusions: These alleles expand the allelic series of blast resistance genes, enriching the genetic resource for rice blast resistance breeding programs and for studies aimed at deciphering rice–rice blast molecular interactions. Key words : Pi9 , R-genes, Nucleotide diversity, Gene conversion, Resistance gene alleles, Rice blast
Awareness of national malaria management guidelines among house officers in Khartoum state teaching hospitals. Sudan 2018
Authors: Aboshanab Mohammed Altyb Alshykh 
Published: December 2019

Abstract

Background: Malaria is a protozoan disease which can lead to serious complications if not treated early and correctly. The aim of this study to assess the knowledge about malaria management guidelines among house officers.Methods: this is the cross sectional observational study conducted at 6 of Khartoum teaching hospitalsResults: The study showed that among the 115 participants evaluated there were 70.4% females and 29.6% were males. 94.8% of participants knew there is malaria management guidelines and 5.2% didn't knew about presence of this guidelines, 58.3% have some information and 10.4% just hear about this guidelines. 89.6% knew the management of simple malaria is an outpatient management. 65.2% of the participants were aware about where to manage the cases of complicated malaria (inpatient or in Intensive Care Unit). 27.8% of the participants were aware about the management of simple malaria in the second and third trimester.Conclusion: Different levels of awareness about malaria management guidelines as whole: 4.3% had an overall poor level of awareness, and 74.8% had an overall average level of awareness and 20.9% had an overall good level of awareness.
Geographic availability and accessibility of day care services for people with dementia in Ireland
Authors: Pierse Tom , Keogh Fiona , O’Shea Eamon , Cullinan John 
Published: December 2019

Abstract
Background Day care is an important service for many people with dementia and their carers. In Ireland, day care services for people with dementia are delivered by a mix of dementia-specific day care centres as well as generic day care centres that cater for people with dementia to various degrees. In this paper we examine the geographic distribution of day care services for people with dementia relative to potential need.MethodsUsing a national survey of day care centres, we estimate the current availability of day care services for people with dementia in the country. We use geographic information systems (GIS) to map day care provision at regional and sub-regional levels and compare this to the estimated number of people with dementia in local areas.Results There is significant variation across the country in the existing capacity of day care centres to cater for people with dementia. The number of places per 100 persons with dementia in the community varies from 14.2 to 21.3 across Community Health Organisation areas. We also show that 18 per cent of people with dementia do not live within 15kms of their nearest day care centre.Conclusion Currently, day care centres, in many parts of the country, have limited capacity to provide a service for people with dementia who live in their catchment area. As the number of people with dementia increases, investment in day care centres should be targeted to areas where need is greatest. Our GIS approach provides valuable evidence that can help inform decisions on future resource allocation and service provision in relation to day care.