bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the relationship between indoor environment and workplace productivity in naturally and mechanically ventilated office environments
Authors: Gupta Rajat , Howard Alastair , Zahiri Sahar 
Published: November 2019

This paper uses a case study-based approach to empirically investigate the relationship between indoor environment and workplace productivity in two contrasting office environments: one naturally ventilated, the other mechanically ventilated. Environmental parameters were continuously monitored over 19 months. Transverse and longitudinal surveys recorded occupants’ perception of their working environment and self-reported productivity, while performance tasks (numerical and proofreading) measured cognitive capability as proxy for measured productivity. Indoor temperatures and CO2 concentrations were found to be higher and more variable in the naturally ventilated office. However, the correlation between occupant perception of their indoor environment and perceived productivity was stronger in the mechanically ventilated office. Occupants of the naturally ventilated office were found to be more tolerant of their environment than their counterparts in the mechanically ventilated office. Task performance was affected by indoor environmental conditions such as indoor temperature and CO2 concentration. Interestingly in the naturally ventilated office, the median scores were up to 12% higher for tests conducted at CO2 concentrations <1400 ppm, compared to those conducted above 1400 ppm, whereas in the mechanically ventilated office, this threshold was only 1000 ppm. The study showed that higher concentrations of CO2 were associated with lower task scores and longer task durations, reinforcing the need for good levels of ventilation in workspaces. It was found that occupants in NV workspaces were able to adapt to a broader range of environmental conditions. Therefore, controlling the indoor environment within narrow ranges (expending significant amounts of energy in the process) may not always be necessary to improve comfort and productivity. On the other hand, controlling indoor environment within a narrow range – as is common in MV workspaces – may be counterproductive, creating occupants who are less tolerant of small changes in their environmental conditions. The study also demonstrates occupant surveys can provide useful feedback on perceived comfort and productivity at relatively low cost. Insights from such surveys can be used to improve indoor environment in workspaces.
Assessing the Quality and Prestige of Disciplinary Social Work Journals: A National Study of Faculty Perceptions
Authors: Hodge David R. , Yu Mansoo , Kim Anna 
Published: November 2019

Purpose: The purpose of this study was to (1) evaluate the overall quality and prestige of all currently active disciplinary social work periodicals and (2) determine whether perceptions of quality among the top 10 journals varied by age, gender, race/ethnicity, and academic rank. Method: To perform this cross-sectional study, we used a national sample of tenure-track faculty ( N = 307) affiliated with PhD granting social work programs. Results: Journals ( N = 64) were rank ordered based upon perceptions of overall quality and prestige. Analysis revealed overall quality and prestige scores were highly correlated ( rs = .93, p < .001). Race/ethnicity was unrelated to perceptions of quality among top-tier journals, but age, gender, and academic rank were significantly associated with perceptions of quality in some cases, although the effect sizes were relatively small. Discussion: The results provide guidance for faculty seeking to disseminate their work in highly regarded disciplinary periodicals, especially junior faculty seeking tenure and promotion.
Patient’s satisfaction beyond hand function in Dupuytren’s disease: analysis of 1106 patients
Authors: Poelstra Ralph , van Kooij Yara E. , van der Oest Mark J. W. , Slijper Harm P. , Hovius Steven E. R. , Selles Ruud W. ,   the Hand-Wrist Study Group
Published: November 2019

This study investigates the outcomes of 1106 patients with Dupuytren’s disease treated with limited fasciectomy or percutaneous needle fasciotomy over 16 years according to the different domains of patient-reported hand function. These patients completed the Michigan Hand Outcomes Questionnaire before and 3 months after surgery. Scores for the various outcome parameters were calculated and linear regression analyses were used to examine associations between the changes in digital extension deficit and change in Michigan Hand Outcomes Questionnaire (sub)scores. We found the largest effects of surgical treatment in the decreases in extension deficit, the appearance of the hand, and the satisfaction with the hand function. However, associations between different domains of evaluation were weak. We conclude that improvement of digital extension deficits is not parallel to varying aspects of patient satisfaction. The findings underline the importance of assessing domains relating to patient satisfaction other than objective hand function measures in Dupuytren’s disease. Level of evidence: IV
Concentration-Dependent Effects of Cobalt and Chromium Ions on Osteoarthritic Chondrocytes
Authors: Bauer Christoph , Stotter Christoph , Jeyakumar Vivek , Niculescu-Morzsa Eugenia , Simlinger Bojana , Rodríguez Ripoll Manel , Klestil Thomas , Franek Friedrich , Nehrer Stefan 
Published: November 2019

Objective Cobalt and chromium (CoCr) ions from metal implants are released into the joint due to biotribocorrosion, inducing apoptosis and altering gene expression in various cell types. Here, we asked whether CoCr ions concentration-dependently changed viability, transcriptional activity, and inflammatory response in human articular chondrocytes. Design Human articular chondrocytes were exposed to Co (1.02-16.33 ppm) and Cr (0.42-6.66 ppm) ions and cell viability and early/late apoptosis (annexin V and 7-AAD) were assessed in 2-dimensional cell cultures using the XTT assay and flow cytometry, respectively. Changes in chondrocyte morphology were assessed using transmitted light microscopy. The effects of CoCr ions on transcriptional activity of chondrocytes were evaluated by quantitative polymerase chain reaction (qPCR). The inflammatory responses were determined by measuring the levels of released pro-inflammatory cytokines (interleukin-1β [IL-1β], IL-6, IL-8, and tumor necrosis factor–α [TNF-α]). Results CoCr ions concentration-dependently reduced metabolic activity and induced early and late apoptosis after 24 hours in culture. After 72 hours, the majority of chondrocytes (>90%) were apoptotic at the highest concentrations of CoCr ions (16.33/6/66 ppm). SOX9 expression was concentration-dependently enhanced, whereas expression of COL2A1 linearly decreased after 24 hours. IL-8 release was enhanced proportionally to CoCr ions levels, whereas IL-1β, IL-6, and TNF-α levels were not affected by the treatments. Conclusions CoCr ions showed concentration- and time-dependent effects on articular chondrocytes. Fractions of apoptotic articular chondrocytes were proportional to CoCr ion concentrations. In addition, metabolic activity and expression of chondrocyte-specific genes were decreased by CoCr ions. Furthermore, exposure to CoCr ions caused a release of pro-inflammatory cytokines.
A Randomized Controlled Trial in the Evaluation of a Novel Stress Management Tool: A Lounge Chair Experience
Authors: Rieck Thomas M , Lee Jennifer R , Ferguson Jennifer A , Peterson Laura A , Martin Lillie Charlene M , Clark Matthew M , Limburg Paul J , Bauer Brent A 
Published: November 2019

Objectives The aim of this study was to compare the stress reduction effects of spending 25 minutes reclining in a SolTec™ Lounge between 2 intervention groups. Group 1 experienced the Lounge with multilayered music on an external speaker, while group 2 experienced the Lounge with multilayered music and synchronous vibration and magnetic stimulation from within the chair. Subjects In total, 110 participants with a self-reported stress level of 4 or higher on a 0- to 10-point scale were recruited from the local community including employees. Participants were randomized into receiving 1 of the 2 interventions. There were no significant differences between the group’s average stress levels prior to the interventions. Interventions Both groups received a 25-minute session in a dimly lit, quiet area on the Lounge with multilayered music. The second group also received vibration and magnetic stimulation that were synchronized with the music. Design Current stress level as well as ratings or feelings of anxiety, tenseness, energy, focus, happiness, relaxation, nervousness, creativeness, and being rested were recorded before and after the session. Results Both groups of participants reported equivalent decreased feelings of stress after using the Lounge. Participants receiving the synchronous multilayered music, vibration, and magnetic stimulation did report significantly reduced feelings of tenseness, feeling more relaxed, and feeling more creative when compared with the group that received music only. Conclusion Spending 25 minutes in the SolTec™ Lounge with multilayered music is an effective way to reduce self-reported stress in individuals who self-report having a high stress level. If confirmed by future studies, including synchronous vibration and magnetic stimulation with the multilayered music might be an effective stress reduction strategy.
Ultrasonic Scattered Field Distribution of One and Two Cylindrical Solids with Phased Array Technique
Authors: Liu Xiaozhou , Ma Jian , Wang Haibin , Gao Sha , Li Yifeng , Liu Jiehui 
Published: November 2019

AbstractThe scattered fields of plane waves in a solid from a cylinder or sphere are critical in determining its acoustic characteristics as well as in engineering applications. This paper investigates the scattered field distributions of different incident waves created by elastic cylinders embedded in an elastic isotropic medium. Scattered waves, including longitudinal and transverse waves both inside and outside the cylinder, are described with specific modalities under an incident plane wave. A model with a scatterer embedded in a structural steel matrix and filled with aluminum is developed for comparison with the theoretical solution. The frequency of the plane wave ranged from 235 kHz to 2348 kHz, which corresponds to scaling factors from 0.5 to 5. Scattered field distributions in matrix materials blocked by an elastic cylindrical solid have been obtained by simulation or calculated using existing parameters. The simulation results are in good agreement with the theoretical solution, which supports the correctness of the simulation analysis. Furthermore, ultrasonic phased arrays are used to study scattered fields by changing the characteristics of the incident wave. On this foundation, a partial preliminary study of the scattered field distribution of double cylinders in a solid has been carried out, and the scattered field distribution at a given distance has been found to exhibit particular behaviors at different moments. Further studies on directivities and scattered fields are expected to improve the quantification of scattered images in isotropic solid materials by the phased array technique.
Teleological pitfalls in reading evolutionary trees and ways to avoid them
Authors: Schramm Thilo , Schmiemann Philipp 
Published: November 2019

AbstractDespite evolution being the central idea in modern biology, considerable variation exists in its acceptance around the globe, and reports of anti-evolutionist and creationist movements are widespread. Educators need to re-evaluate the approaches used for teaching students about evolution in order to facilitate its understanding and acceptance. A major hurdle in understanding the concepts of evolution is that humans tend to view the world in a teleological way. Learners create obstacles to understanding the concepts of evolution by ascribing purpose or intent-driven actions to animals, processes, or inanimate objects. An indispensable learning tool in the field of evolution is the evolutionary tree, as it is a direct representation of evolutionary hypotheses. The ability to read and understand this form of representation is prerequisite to fully understanding the concepts of evolution. In this work, we present issues faced when attempting to teach students to read evolutionary trees as well as troublesome diagrammatic properties that may foster teleological thinking. Further, we present teaching practices and methods that may be used to avoid the above challenges (from diagrammatic and instructional perspectives). With this work, we aim to raise awareness among educators about the different potential teleological pitfalls in the field of teaching how to read evolutionary trees, and to present different approaches for minimizing teleological reasoning and thinking in evolution education.
HKPocket: human kinase pocket database for drug design
Authors: Wang Huiwen , Qiu Jiadi , Liu Haoquan , Xu Ying , Jia Ya , Zhao Yunjie 
Published: November 2019

Abstract
Background
The kinase pocket structural information is important for drug discovery targeting cancer or other diseases. Although some kinase sequence, structure or drug databases have been developed, the databases cannot be directly used in the kinase drug study. Therefore, a comprehensive database of human kinase protein pockets is urgently needed to be developed.

Results
Here, we have developed HKPocket, a comprehensive Human Kinase Pocket database. This database provides sequence, structure, hydrophilic-hydrophobic, critical interactions, and druggability information including 1717 pockets from 255 kinases. We further divided these pockets into 91 pocket clusters using structural and position features in each kinase group. The pocket structural information would be useful for preliminary drug screening. Then, the potential drugs can be further selected and optimized by analyzing the sequence conservation, critical interactions, and hydrophobicity of identified drug pockets. HKPocket also provides online visualization and pse files of all identified pockets.

Conclusion
The HKPocket database would be helpful for drug screening and optimization. Besides, drugs targeting the non-catalytic pockets would cause fewer side effects. HKPocket is available at http://zhaoserver.com.cn/HKPocket/HKPocket.html.
Binding of Brucella protein, Bp26, to select extracellular matrix molecules
Authors: ElTahir Yasmin , Al-Araimi Amna , R. Nair Remya , Autio Kaija J. , Tu Hongmin , Leo Jack C. , Al-Marzooqi Waleed , H. Johnson Eugene 
Published: November 2019

Abstract
Background
Brucella is a facultative intracellular pathogen responsible for zoonotic disease brucellosis. Little is known about the molecular basis of Brucella adherence to host cells. In the present study, the possible role of Bp26 protein as an adhesin was explored. The ability of Brucella protein Bp26 to bind to extracellular matrix (ECM) proteins was determined by enzyme-linked immunosorbent assay (ELISA) and biolayer interferometry (BLI).

Results
ELISA experiments showed that Bp26 bound in a dose-dependent manner to both immobilized type I collagen and vitronectin. Bp26 bound weakly to soluble fibronectin but did not bind to immobilized fibronectin. No binding to laminin was detected. Biolayer interferometry showed high binding affinity of Bp26 to immobilized type I collagen and no binding to fibronectin or laminin. Mapping of Bp26 antigenic epitopes by biotinylated overlapping peptides spanning the entire sequence of Bp26 using anti Bp26 mouse serum led to the identification of five linear epitopes. Collagen and vitronectin bound to peptides from several regions of Bp26, with many of the binding sites for the ligands overlapping.
The strongest binding for anti-Bp26 mouse serum, collagen and vitronectin was to the peptides at the C-terminus of Bp26. Fibronectin did not bind to any of the peptides, although it bound to the whole Bp26 protein.

Conclusions
Our results highlight the possible role of Bp26 protein in the adhesion process of Brucella to host cells through ECM components. This study revealed that Bp26 binds to both immobilized and soluble type I collagen and vitronectin. It also binds to soluble but not immobilized fibronectin. However, Bp26 does not bind to laminin.
These are novel findings that offer insight into understanding the interplay between Brucella and host target cells, which may aid in future identification of a new target for diagnosis and/or vaccine development and prevention of brucellosis.
Trans-splicing of mRNAs links gene transcription to translational control regulated by mTOR
Authors: Danks Gemma B. , Galbiati Heloisa , Raasholm Martina , Torres Cleuren Yamila N. , Valen Eivind , Navratilova Pavla , Thompson Eric M. 
Published: November 2019

Abstract
Background
In phylogenetically diverse organisms, the 5′ ends of a subset of mRNAs are trans-spliced with a spliced leader (SL) RNA. The functions of SL trans-splicing, however, remain largely enigmatic.

Results
We quantified translation genome-wide in the marine chordate, Oikopleura dioica, under inhibition of mTOR, a central growth regulator. Translation of trans-spliced TOP mRNAs was suppressed, consistent with a role of the SL sequence in nutrient-dependent translational control of growth-related mRNAs. Under crowded, nutrient-limiting conditions, O. dioica continued to filter-feed, but arrested growth until favorable conditions returned. Upon release from unfavorable conditions, initial recovery was independent of nutrient-responsive, trans-spliced genes, suggesting animal density sensing as a first trigger for resumption of development.

Conclusion
Our results are consistent with a proposed role of trans-splicing in the coordinated translational down-regulation of nutrient-responsive genes under growth-limiting conditions.
Transcriptional profiling of long noncoding RNAs associated with leaf-color mutation in Ginkgo biloba L
Authors: Wu Yaqiong , Guo Jing , Wang Tongli , Cao Fuliang , Wang Guibin 
Published: November 2019

Abstract
Background
Long noncoding RNAs (lncRNAs) play an important role in diverse biological processes and have been widely studied in recent years. However, the roles of lncRNAs in leaf pigment formation in ginkgo (Ginkgo biloba L.) remain poorly understood.

Results
In this study, lncRNA libraries for mutant yellow-leaf and normal green-leaf ginkgo trees were constructed via high-throughput sequencing. A total of 2044 lncRNAs were obtained with an average length of 702 nt and typically harbored 2 exons. We identified 238 differentially expressed lncRNAs (DELs), 32 DELs and 49 differentially expressed mRNAs (DEGs) that constituted coexpression networks. We also found that 48 cis-acting DELs regulated 72 target genes, and 31 trans-acting DELs regulated 31 different target genes, which provides a new perspective for the regulation of the leaf-color mutation. Due to the crucial regulatory roles of lncRNAs in a wide range of biological processes, we conducted in-depth studies on the DELs and their targets and found that the chloroplast thylakoid membrane subcategory and the photosynthesis pathways (ko00195) were most enriched, suggesting their potential roles in leaf coloration mechanisms. In addition, our correlation analysis indicates that eight DELs and 68 transcription factors (TFs) might be involved in interaction networks.

Conclusions
This study has enriched the knowledge concerning lncRNAs and provides new insights into the function of lncRNAs in leaf-color mutations, which will benefit future selective breeding of ginkgo.
The role of OX40L and ICAM-1 in the stability of coronary atherosclerotic plaques and their relationship with sudden coronary death
Authors: Wang Yu , Sun Xiaoyu , Xia Bing , Le Cuiyun , Li Zhu , Wang Jie , Huang Jiang , Wang Jiawen , Wan Changwu 
Published: November 2019

AbstractBackgroundCoronary heart disease is related to sudden death caused by multi-factors and a major threat to human health.This study explores the role of OX40L and ICAM-1 in the stability of coronary plaques and their relationship with sudden coronary death.MethodsA total of 118 human coronary arteries with different degrees of atherosclerosis and/or sudden coronary death comprised the experimental group and 28 healthy subjects constituted the control group were isolated from patients. The experimental group was subdivided based on whether the cause of death was sudden coronary death and whether it was accompanied by thrombosis, plaque rupture, plaque outflow and other secondary changes: group I: patients with coronary atherosclerosis but not sudden coronary death, group II: sudden coronary death without any of the secondary changes mentioned above, group III: sudden coronary death with coronary artery atherosclerotic lesions accompanied by either of the above secondary changes. The histological structure of the coronary artery was observed under a light microscope after routine HE staining, and the related indexes of atherosclerotic plaque lesions were assessed by image analysis software. The expressions of OX40L and ICAM-1 were detected by real-time quantitative PCR (RT-PCR), immunohistochemistry (IHC) and Western blotting, and the correlations between the expressions and the stability of coronary atherosclerotic plaque and sudden coronary death were analyzed.Results(1) The expression of OX40L protein in the control group and the three experimental groups showed an increasing trend, and the difference between groups was statistically significant (P < 0.05). (2) The expression of the ICAM-1 protein in the control group and the three experimental groups showed a statistically significant (P < 0.05) increasing trend. (3) The expression of OX40L and ICAM-1 mRNAs increased in the control and the three experimental groups and the difference was statistically significant (P < 0.05).ConclusionThe expression of OX40L and ICAM-1 proteins and mRNAs is positively correlated with the stability of coronary atherosclerotic plaque and sudden coronary death.