bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Tendencies in Contemporary Foreign Trade Policy
Authors: W. Puślecki Zdzisław 
Published: November 2019

In this research work, the author focuses on the analysis new tendencies in contemporary foreign trade policy. Accordance to the foreign trade policy theory further trade liberalization and improved framework policies would increase trade and promote growth. It must be emphasized that openness to trade is associated with higher incomes and growth and there is the need for new approaches to trade cooperation in light of the forces that are currently re-shaping international business. What indicates the importance and innovativeness of the research is the presentation of the new models of foreign trade policy and trade interests. First of all it must underline that in the new theoretical terms in the demand for trade policy very important is factor specificity. The low specificity of factors means that factor returns are equalized throughout a region’s economy. On the other hand some factors are stuck in their present uses; therefore, factor returns are not equalized throughout a region’s economy but are industry-specific. The main objective of the research task is to give a comprehensive analysis of current trends in foreign trade theory and policy and in particular the models of foreign trade policy, trade interests indicated by export orientation and import sensitivity, foreign trade policy in different types of authoritarian regimes, protectionism pressures in different political system, the level of protectionism pressures, the variation in the foreign trade policy among states, the liberalization of China foreign trade policy and their effects, the tendencies to international trade liberalization and the problem of environmental protection, and the tendencies to bilateralism in the foreign trade policy. It should be stressed that free trade in itself is not responsible for economic growth, but more significant are the determining macroeconomic stability and increasing investment.
Safety and Efficacy of Anti–IL-23 Monoclonal Antibody QX004N for Patients With Psoriasis
Authors: Li Xiaojiao , Li Bing , Yang Deming , Wang Meng , Li Qianqian , Wang Nan , Fang Min , Liu Jingrui , Zhang Hong , Wu Min , Li Cuiyun , Zhu Xiaoxue , Ding Yanhua , Li Shanshan 
Published: December 2024

ImportancePsoriasis is a chronic, immune-mediated skin disease with an unmet need for biologic treatment options.ObjectiveTo assess the safety, pharmacokinetics, and efficacy of QX004N in healthy individuals and patients with moderate to severe plaque psoriasis in China.Design, Setting, and ParticipantsThis randomized clinical trial was composed of 2 parts. Part 1 was a first-in-human, single-ascending-dose, phase 1a clinical trial conducted from November 2, 2021, to January 16, 2023. Part 2 was a double-blind, multiple dose-escalation, phase 1b clinical trial conducted from February 15, 2023, to January 5, 2024, at 5 clinical centers in China, involving patients with moderate to severe plaque psoriasis.InterventionsIn part 1, healthy participants in each cohort were assigned in a 4:1 ratio to receive a single subcutaneous injection of QX004N (ranging from 10 mg to 600 mg) or placebo. In part 2, patients in each cohort were assigned in a 4:1 ratio to receive QX004N or placebo at doses of 150 mg, 300 mg, and 600 mg once every 2 weeks.Main Outcomes and MeasuresFor part 1, the primary outcome was the safety of a single dose of QX004N in healthy participants, and the secondary outcome was the pharmacokinetic profile. For part 2, the primary efficacy end point was the proportion of patients achieving at least 75% improvement in Psoriasis Area and Severity Index (PASI 75) by week 12; other efficacy end points were considered secondary.ResultsThe phase 1a clinical trial (part 1) enrolled 55 healthy participants (mean [SD] age, 35.9 [6.0] years; 30 [54.5%] female), and the phase 1b clinical trial (part 2) enrolled 30 patients with moderate to severe plaque psoriasis. The mean (SD) age of QX004N-treated participants in part 2 was 41.4 (7.5) years, and 19 of 24 QX004N-treated participants (79.2%) were male. The mean (SD) age of the placebo cohort in part 2 was 35.3 (8.4) years, and 5 of 6 placebo-treated participants (83.3%) were male. QX004N exhibited linear pharmacokinetics and was tolerated well in both healthy participants and patients with psoriasis. Most adverse events were mild to moderate in severity, with no drug-related serious adverse events reported. The proportion of patients receiving QX004N who achieved PASI 75 at week 12 and PASI 90 (90% improvement in PASI) at week 16 in the 150-mg, 300-mg, and 600-mg cohorts was 100%, significantly higher than that in the placebo cohorts (33.3%). The maximum proportion of patients achieving Investigator’s Global Assessment score of 0 or 1 was 100% in the 3 QX004N cohorts.Conclusions and RelevanceIn this randomized clinical trial, QX004N was well tolerated and demonstrated superior efficacy compared to placebo in patients with moderate to severe plaque psoriasis.Trial RegistrationChinese Clinical Trial Registry Identifier: CTR20212313 and CTR20223457
Cathodic Reversible Selenium Redox Chemistry Over Oxygen Vacancies‐Dominated V2O3/Graphene for Rechargeable Mg‐Se Batteries
Authors: Jiang Rong , Jin Mingwei , Peng Shichao , Zhang Qianwei , Du Changliang , Ma Xilan , Zhu Youqi , Cao Chuanbao , Zou Meishuai 
Published: December 2024

AbstractRechargeable magnesium‐selenium (Mg‐Se) batteries are characterized by high theoretical volumetric specific capacity, good cycling stability, and economical effectiveness. However, great challenges including limited capacity, low Coulombic efficiency, and short cycle life are encountered due to sluggish electrochemical kinetics and severe polyselenide shuttles. Herein, the active Se is encapsulated in hollow V2O3 microspheres and then connected by reduced graphene oxide (rGO) conductive network as the mixed‐dimensional cathode materials to accelerate reversible Se redox chemistry for high‐performance Mg‐Se batteries. Rich oxygen vacancies are generated within hollow porous V2O3 microspheres during their phase transformation under reductive atmosphere. The unique three‐/two‐dimensional (3D/2D) heterostructure of the Se‐loaded cathode materials (Se‐V2O3/G‐Vo) can facilitate Mg2+ diffusion and charge transfer, and also provide rich reaction sites for the polyselenide conversion. Additionally, the defect‐rich structure can deliver strong adsorption ability and abundant catalytic sites for reversible polyselenide conversion. Consequently, the Se‐V2O3/G‐Vo cathode materials show high reversible capacity of 580 mAh g−1 with 99.1% capacity retention at 200 mA g−1 current density after 80 cycles. This work should enlighten the design concept of metal oxide and graphene as Se‐based cathode materials for high‐rate and long‐life Mg‐Se batteries.
Long‐Term Used Continuous Blood Pressure Monitoring via Personalized Object Transfer Learning Architecture Enhanced Triboelectric Pulse Sensors
Authors: Yao Chuanjie , Liu Suhang , Xu Xingyuan , Yun Peng , Zhang Tao , Sun Tiancheng , He Mengyi , Liang Baoming , Li Minghao , Huang Shuang , Li Yan , Wang Yunuo , Chen Hui‐jiuan , Xie Xi 
Published: December 2024

AbstractCardiovascular diseases remain the leading cause of global mortality, underscoring the importance of continuous blood pressure (BP) monitoring for early diagnosis and management. However, due to individual diversity and temporal variability of patients physiological characteristics, traditional BP models suffer from inaccuracies over time, hampering the practical applications of continuous BP monitoring devices. Herein, a personalized object transfer learning architecture (POTLA) enhanced triboelectric pulse sensor is developed for accurate long‐term used continuous BP monitoring. Utilizing inversed molding‐replica technique, a nanopillar triboelectric pulse sensor (NTPS) is fabricated, which possesses desirable linear response, high sensitivity, and remarkable durability. The NTPS can detect the detailed features of pulse signals for BP derivation. Further, the POTLA is proposed to enhanced the BP models, which effectively addresses the individual diversity and temporal variability, thereby minimizing errors in BP monitoring for long‐term use of the sensors. A 6‐month follow‐up test involving five participants demonstrates that the POTLA significantly optimizes the BP derivation, with accuracy improvements of >27%, comparing to the universal and personalized BP models without the POTLA. This POTLA‐coupled sensor strategy holds promise for enhancing precision medicine and advancing healthcare applications.
Epitaxial Growth of Phosphorene on Cu Substrate: The Essential Role of Interface Strain
Authors: Niu Tianchao , Gao Wenjin , Xu Ke , Wang Xue‐Sen , Zhou Miao 
Published: December 2024

AbstractTwo‐dimensional (2D) material epitaxially grown on a metal substrate with precise lattice registry and strong bonding can result in substantial strain within both the 2D layer and the metal surface. In turn, the strain energy has a pronounced influence on the morphology and physical properties of epitaxial films. Here, through a comprehensive approach by combining scanning tunneling microscopy and atomistic simulations, it is demonstrated that monolayer ultraflat blue phosphorene (blueP) and the topmost Cu(111) layer are in the perfect atomic registry. This Cu layer undergoes significant compressive strain, giving rise to a semi‐coherent interface between the blueP‐attached Cu layer and the underlying Cu layers. Straight and spiral dislocation patterns are observed due to strain relief, which strongly depends on the thermal annealing temperature. Dislocation lines intersect to form periodic nodes that can adopt multiple atomic arrangements correlated to the dislocation patterns. Stone‐Wales defects are distinctly imaged within the blueP layer, exhibiting periodic corrugations along the dislocation lines due to the presence of interface strain. This work underscores the potential of epitaxial layers with strong interfacial interactions as promising model systems for exploring dislocation theory and the implication for material functionality engineered by strain.
Enhancement of De‐Solvation Kinetics on V5O12•6H2O Cathode Through a Bi‐Functional Modification Layer for Low‐Temperature Zinc‐Ion Batteries
Authors: Jiang Xiaodi , Wang Tongde , Ji Mingze , Ji Dong , Deng Shengyuan , Gao Guohua , shen Jun , Wu Guangming 
Published: December 2024

AbstractZinc‐ion batteries (ZIBs) show great promise for next‐generation energy storage, but their performance at low temperatures is severely hindered by sluggish desolvation kinetics at cathode‐electrolyte interface. To address this limitation, a zincophilic‐hydrophobic poly(3,4‐ethylenedioxythiophene) (PEDOT) modified layer is proposed on V5O12•6H2O cathode. Ab initio molecular dynamics simulations indicate that this modification strategy promotes Zn2⁺ adsorption and reduces the free energy for dissociating hydrated Zn2+ to form Zn2+ at the cathode‐electrolyte interface, across the temperature of 280 to 240 K. As a result, this PEDOT‐modified cathode exhibits significantly improved Zn2⁺ diffusion and desolvation kinetics, delivering superior rate performance with a remarkable capacity of 226.5 mAh g⁻¹ at 40 A g⁻¹. Notably, even at −30 °C, this cathode maintains a high capacity of 268.3 mA g⁻¹ at 0.2 A g⁻¹ and exhibits robust capacity retention (92.4%) over 1,000 cycles at 1 A g⁻¹. This approach markedly improves low‐temperature capacity retention and operational efficiency, highlighting the potential of cathode‐electrolyte interface engineering to advance zinc‐ion batteries performance in cold environments.
Sequential Release HydroLipo System for STING Gene Epigenetic Reprogramming and Immune Activation in Glioblastoma
Authors: Yu Hao , Liu Wenjing , Ding Kaikai , Wu Jiangjie , Wang Cheng , Wang Siyuan , Wu Lingyun , Tang Qiuying , Yin Xin , Jiang Kan , Yan Danfang , Wang Xu , Chen Si , Yan Senxiang 
Published: December 2024

AbstractGlioblastoma (GBM) remains a daunting oncological challenge because of its aggressive nature and resistance to conventional therapies. Inhibition of the intrinsic STING pathway in GBM hampers the effectiveness of immunotherapies. To overcome this clinical limitation, a Sequential Release HydroLipo System (SRHLS) is developed, in which hydrogels and nanoparticles are combined for controlled drug release. The SRHLS sequentially released decitabine and STING agonists, thereby correcting STING signaling dysfunction through epigenetic reprogramming and enhancing antitumor immunity. According to in vitro and in vivo experiments, the SRHLS reshaped the tumor microenvironment and markedly inhibited tumor growth, recurrence, and metastasis. These findings underscore the potential of the SRHLS as a promising therapeutic strategy for GBM.
Meso Hybridized Silk Fibroin Watchband for Wearable Biopotential Sensing and AI Gesture Signaling
Authors: Wang Xiao , Lu Changsheng , Jiang Zerong , Shao Guangwei , Cao Jingzhe , Liu Xiang Yang 
Published: December 2024

AbstractHuman biopotential signals, such as electrocardiography, are closely linked to health and chronic conditions. Electromyography, corresponds to muscle actions and is pertinent to human‐machine interactions. Here, we present a type of smart and flexible watchband that includes a mini flexible electrode array based on Mo‐Au filament mesh, combined with mesoscopic hybridized silk fibroin films. As the layer in contact with the skin, waterborne polyurethane and SF create a highly flexible and permeable meso‐hybridized SF/WPU layer, ensuring skin‐friendliness and comfortable wearing. The flexible FM electrodes are created by integrating Mo‐Au FM into 2D‐interconnected networks. Molybdenum filaments provide high rigidity and are coated with Aurum to enhance conductivity. The use of Mo‐Au FMs in warp‐knitted patterns results in high SNR (43.22 dB), high sensitivity (44.43 mV/kg), and significant motion noise reduction due to the pattern's elastic deformability and skin‐gripping properties. Leveraging these unique technologies, these smart watchbands excel in prolonged sensing operation, grasping force detection, and gesture recognition. Through smart raining via deep learning, we achieved an unparalleled recognition rate (96% across 20 volunteers of different genders) among other EMG sensing devices. These results have significant implications for human‐machine interaction, including applications in underwater robot control, drone operation, and autonomous vehicle control.
Covalent Organic Frameworks for Membrane Separation
Authors: Jin Yuan‐Hang , Li Meng‐Hao , Yang Ying‐Wei 
Published: December 2024

AbstractMembranes with switchable wettability, solvent resistance, and toughness have emerged as promising materials for separation applications. However, challenges like limited mechanical strength, poor chemical stability, and structural defects during membrane fabrication hinder their widespread adoption. Covalent organic frameworks (COFs), crystalline materials constructed from organic molecules connected by covalent bonds, offer a promising solution due to their high porosity, stability, and customizable properties. The ordered structures and customizable functionality provide COFs with a lightweight framework, large surface area, and tunable pore sizes, which have attracted increasing attention for their applications in membrane separations. Recent research has extensively explored the preparation strategies of COF membranes and their applications in various separation processes. This review uniquely delves into the influence of various COF membrane fabrication techniques, including interfacial polymerization, layer‐by‐layer assembly, and in situ growth, on membrane thickness and performance. It comprehensively explores the design strategies and potential applications of these methods, with a particular focus on gas separation, oil/water separation, and organic solvent nanofiltration. Furthermore, future opportunities, challenges within this field, and potential directions for future development are proposed.
Mechanical Degradation by Anion Redox in LiNiO2 Countered via Pillaring
Authors: Bergschneider Matthew , Kong Fantai , Conlin Patrick , Hwang Taesoon , Doo Seok‐Gwang , Cho Kyeongjae 
Published: December 2024

AbstractA promising next‐generation high‐energy cathode material, LiNiO2 (LNO) has failed to realize commercialization due to severe capacity degradation during cycling. The dual mechanisms of surface oxygen evolution due to anion redox and anisotropic volume change upon delithiation synergistically pulverize and degrade the material. Detailed Density Functional Theory (DFT) modeling and analysis of the anisotropic structural changes associated with crack formation in LiNiO2 (LNO) reveals the link of mechanical behavior to charge transfer and oxygen redox activity upon deep charge cycling (>4.2 V vs Li/Li+). In the two‐phase region and H2–H3 transition from 66% to 100% delithiation, oxygen of [NiO6] octahedra is discovered to undergo redox in growing the Li‐deficient regions, causing c‐lattice mechanical weakening and collapse as the Li‐slab becomes depleted. Li‐site dopants are investigated to locally compensate against anion redox, resulting in enhanced coulombic repulsion and supporting the interslab layer thickness even at 100% depth of charge. Ionic size and oxidation state of M in Lix‐yMyNiO2 are found to fundamentally impact stabilization capability, moderating the anisotropic strain and volume expansion asynchronously. Optimization of mixed doping composition may then enable “zero strain” high‐Ni Li(Ni,Co,Mn)O2 (NCM) or LNO.
Plasma‐Induced Construction of S‐Scheme Heterojunctions Enables Photo‐Enhanced Peroxymonosulfate Activation for Gaseous Toluene Removal
Authors: Miao Huanran , Yao Huiqin , Li Yong , Zhang Xinwei , Wang Huai , Zhang Xiai , Wang Ge , Fan Qikui , Yang Zhimao , Zhou Cheng , Liu Ben , Kong Chuncai 
Published: December 2024

AbstractSelective activation of peroxymonosulfate (PMS) represents an efficient route to generate the reactive oxygen species (ROS) for the degradation and deep mineralization of organic pollutants, but its activity and selectivity are remarkably lower than what is needed. Herein, an S‐scheme heterojunction is developed to effectively modify surface electronic properties and introduce abundant oxygen vacancies, thereby enabling photo‐enhanced PMS activation for selective removal of gaseous toluene. S‐scheme heterojunction is fabricated by in situ growth of ultrathin Co3O4 nanoparticles on g‐C3N4 nanosheets through a rapid plasma treatment. The electronic field at the S‐scheme heterostructure interface of Co3O4/g‐C3N4 (COCN) facilitates charge transfer, selectively removing low‐redox electrons and holes while separating high‐redox ones. Photo‐excited electrons promote the Co3+/Co2+ redox cycle, thereby enhancing ROS generation and creating continuous PMS activation sites. The COCN catalyst demonstrates remarkably high degradation efficiency (90.2%) and mineralization rate (68.5%) for flowing gaseous toluene in aqueous solution. This study thus provides a feasible strategy for plasma‐induced electronic modulation and offers new insights for future heterojunction design aimed at efficient PMS activation.
Synthesis of a Direct Dual Z‐Scheme g‐C3N4/Bi2S3/NiFe2O4 Photocatalyst for Degradation of Organic Pollutants: Optimization Using Response Surface Methodology
Authors: Merci Sanaz , Shamspur Tayebeh , Mostafavi Ali 
Published: December 2024

ABSTRACTIn photocatalytic reactions, the fast recombination rate of photogenerated charge carriers limits practical application. So, in this study, a new g‐C3N4/Bi2S3/NiFe2O4 nanocomposite was synthesized with dual Z‐scheme heterojunctions to enhance charge carrier separation and visible light absorption. The structure, morphology, composition, magnetic, surface potential, and optical properties of the prepared g‐C3N4/Bi2S3/NiFe2O4 nanocomposite were investigated using XRD, FTIR, Raman, FESEM‐EDS‐Mapping, TEM, VSM, Zeta potential, PL, and UV–vis DRS techniques. Also, the photocatalytic performance and mechanism of enrofloxacin (Enro) and malachite green (MG) degradation under visible light were studied. Also, the photocatalytic performance and photodegradation mechanism were studied by enrofloxacin and malachite green degradation under visible light. The effect of the main parameters on the degradation performance of both pollutants was studied by response surface methodology (RSM). Under the optimum conditions, the highest photocatalytic degradation percentages for enrofloxacin and malachite green were obtained at 91.89% and 95.63%, respectively. The apparent rate constants of Enro and MG photodegradation over g‐C3N4/Bi2S3/NiFe2O4 were found to be 0.0628 min−1 and 0.0504 min−1, respectively. Based on its magnetic characteristics, the as‐prepared catalyst demonstrated facile recovery and good photocatalytic stability after six recycling studies, according to the results.
Graphene Oxide Decorated SiO2/Fe3O4 as a Recyclable Catalyst for the Green Synthesis of Novel Thiazinoazepines via Multicomponent Reaction of Isatoic Anhydrides: Cytotoxic Activity and Theoretical Study
Authors: Mohammadi Marziyeh , Azizi Zahra , Hossaini Zinatossadat 
Published: December 2024

ABSTRACTThis work investigated the use of a complex technique including isatoic anhydrides, α‐haloketones, electron‐deficient acetylenic compounds, ammonium acetate, and isothiocyanates in a water‐based solution at normal room temperature in the presence of SiO2/Fe3O4@Graphene Oxide. The goal was to generate novel thiazinoazepine molecules with significant yields. The thiazinoazepines that have been synthesized contain NH functional groups with acidic protons and demonstrate notable antioxidant activity. The (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide), MTT assay was utilized to evaluate the cytotoxicity of all the synthesized compounds in vitro against cancer cell lines (MCF‐7 and A549) as well as normal cell lines). Cytotoxicity refers to the ability of a compound to kill cells. The derivative 6e was shown to be the most potent cytotoxic agent, similar to doxorubicin in its lack of selectivity. Alternatively, compound 6b might be considered as a compound that is equally effective but more selective than doxorubicin. Quantum chemical approaches utilizing density functional theory have been utilized to enhance comprehension of reaction mechanisms. The used technology for synthesizing thiazinoazepines provides several advantages, including rapid reaction kinetics, outstanding product yield, and straightforward product isolation.
Aggregation‐Driven Fluorescence Behavior of EuMOF for Aldehydes Detection
Authors: Xu Heng , Wu Xueqiang , Chen Ruhan , Zhang Wanli , Zhang Xiaonan , Liu Zhiwei 
Published: December 2024

ABSTRACTThis research leverages the fluorescence properties of a europium metal–organic framework (EuMOF) to assess the presence of aldehydes in food. The EuMOF demonstrates three distinct excitation peaks, with an unusual change in fluorescence intensity attributed to the excessive aggregation observed in the initial two peaks. Aldehydes, specifically monoaldehyde compounds (MACs) and dialdehyde compounds (DACs), can engage with the amine groups on the surface of the EuMOF through a Schiff reaction. This interaction disrupts the accumulation process during dilution and allows for the quantification and differentiation of aldehyde compounds based on their unique fluorescence behaviors. By conducting a series of sample dilutions, the ratio between the first two fluorescence excitation peaks can be determined, leading to the creation of a data matrix. The quantitative evaluation of aldehyde‐derived compounds is enabled by deconstructing the original sample matrix using reference matrices of EuMOF and a reaction mixture containing the aldehyde standard. This innovative technique for monitoring aldehydes eliminates the need for sample pretreatment, aldehyde derivatization, and the use of hazardous chemicals in the detection process, offering significant economic and public health benefits.