bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a single interprofessional simulation session on medical and nursing students’ attitudes toward interprofessional learning and professional identity: A questionnaire study
Authors: Burford Bryan , Greig Paul , Kelleher Michael , Merriman Clair , Platt Alan , Richards Elize , Davidson Neil , Vance Gill 
Published: December 2019

Abstract
BackgroundParticipation in simulation-based interprofessional education (sim-IPE) may affect students’ attitudes towards interprofessional learning (through gaining experience with others) and their professional identity (by increasing the ‘fit’ of group membership by performing a role). We examined this in two questionnaire studies involving two sites, with students drawn from four universities. MethodQuestionnaire data were collected before and after students took part in a sim-IPE session consisting of three acute scenarios.Questionnaires included the Readiness for Interprofessional Learning Scale (RIPLS) and measures of professional identity derived from the social identity theory literature. In Study 1 only identification with professional group was measured, while in Study 2 identification with Student group and the immediate interprofessional team were also measured.Linear mixed effects regression analysis examined the effect of the simulation session, and differences between medical and nursing students, between sites and between measures of Professional, Student and Team identity.Results194 medical and 266 nursing students completed questionnaires across the two studies.In both studies RIPLS increased for all groups following participation in sim-IPE, although this was larger for nursing students in Study 1. Nursing students had consistently higher RIPLS scores than medical students at one site.Effects of the simulation session on identity measures varied between sites and different dimensions of identity. Notably, while positive emotions associated with group membership increased for Student group, Professional group and Team, the sense of belonging (Ingroup Ties) and centrality of the group increased only for Team. There were also differences between sites. Nursing students had consistently higher identification scores than medical students.ConclusionsParticipation in a single sim-IPE can improve attitudes towards interprofessional learning. It can also enhance aspects of professional identity, particularly those related to affect, with potential benefits for wellbeing. Changes in identification with an immediate Team may suggest positive psychological consequences of ad hoc Team formation in the workplace.Differences between medical and nursing students suggest that their differing opportunities to work with other professions during training may change baseline attitudes and identity, but a single sim-IPE session can still have an additive effect.
Does simulation suffice? Teaching procedural skills in undergraduate medical students- observational quasi-experimental study.
Authors: Naylor Katarzyna , Torres Kamil 
Published: December 2019

Abstract
Background. Medical simulation as a teaching method is concerned with close mirroring of the real clinical conditions, it is designed to develop skills from the clinical environment, under the guidance of experienced instructors, it allows standardization and repeatability of the skills taught. As a result, students acquire skills and competences, become acquainted with the medical equipment needed to perform a given procedure without endangering patients. The presented research attempts to evaluate the application of medical simulation techniques in the teaching of basic clinical skills using original instructional videos and the Peyton approach. Also, an attempt was made to assess how the applied interventions affect the assessment regarding the usefulness of the course by the students of medicine in comparison with the results of practical assessment in the form of OSCE. Materials. The research was conducted in the period from May 2015 to June 2017, among 750 students of the medical faculty of the Medical University in Lublin. The study used a self-reported questionnaire and documentation analysis with the results of practical assessment. The obtained results were statistically analyzed.Results. The overall students scored the BCS course high (good and very good). The highest values were assigned to Stage III of the research. The introduction of simulation techniques along with the original instructional videos and the Peyton approach positively reflected in the results obtained in the final assessment, OSCE, especially in case of invasive procedures: peripheral vein cannulation and urinary bladder catheterization. Conclusions. Consequently, obtained results allowed concluding that the use of medical simulation techniques in the teaching of basic clinical skills using modern methodologies and teaching interventions: original instructional videos and the Peyton approach affected the positive assessment of the usefulness of the simulation course by students, as well as improve and support the process of acquiring basic skills clinical in the early years of medical training.
Effect of Meteorological Conditions on Storability of the Scab-Immune Columnar Apple Varieties
Authors: Nikitin Andrej , Makarkina Margarita 
Published: December 2019

Introduction. Weather conditions during vegetative period have an effect on the duration of fruit storage, as well as the yield of commercial fruits unaffacted by physiological disorders or microbiological diseases. In this regard, new apple varieties demand a detailed study of economic and biological indicators, determination of storage period, and various factors that may affect it.
Study objects and methods. The research featured preservation capacity of five new scab-immune columnar apple varieties cultivated at the All-Russian Research Institute for Fruit Crop Breeding (Orlov Region, Russia), namely ‘Vostorg’, ‘Zvezda’ ‘Efira’, ‘Poezia’, ‘Priokskoye’, and ‘Sozvezdiye’. The apples were stored in an industrial refrigerator at +2°C. The Selyaninov’s hydrothermal coefficient (HTC) was used as a predictive indicator of the potentially effective storability.
Results and discussion. A set of experiments was conducted to determine the effect of the weather conditions during the vegetative period on the yield of commercial fruits. The best preservation was recorded for the fruits harvested in the years with sufficient rainfall during the growing season. The most comfortable conditions of seasonal humidification for the long-term storage of fruits were formed for ‘Zvezda Efira’ and ‘Sozvezdiye’ in 2014 and ‘Poezia’ and ‘Priokskoye’ in 2016 at HTC = 1.0. The storability depended on the weather conditions during the growing season and the variety. The ‘Sozvezdiye’ variety showed the highest commercial yield after storage in 2014 (96.7%), while the lowest commercial yield (64.2%) belonged to the ‘Vostorg’ apples in 2016. ‘Sozvezdiye’ had the highest effective persistence of commercial fruits (83.6–96.7%) during the whole study period (92.0% on average). ‘Vostorg’ and ‘Poezia’ demonstrated worse results than other varieties (76.2% and 76.8% on average, respectively).
Conclusion. Poor precipitation and excess heat in the period of 30 days before harvesting adversely affected the fruit storability, which led to scald. ‘Zvezda Efira’ and ‘Sozvezdiye’ were absolutely stable to scald. The dry year of 2012 had a positive effect on the apples as the level of ascorbic acid increased during storage (82.8% of the baseline). Therefore, it is advisable to use HTC to predict fruit quality and storage period.
Survival of emerging pathogen Acinetobacter baumannii in water environment exposed to different oxygen conditions
Authors: Dekic Svjetlana , Hrenovic Jasna , van Wilpe Erna , Venter Chantelle , Goic-Barisic Ivana 
Published: December 2019

Abstract
Bacterium Acinetobacter baumannii is a leading cause of hospital infections. Over the last decade, its occurrence in natural environments outside hospital settings has been reported. The aim was to examine the survival of A. baumannii in water media exposed to different ranges of oxygen supply in order to predict its behaviour in the environment. The abundance of five A. baumannii isolates was monitored in nutrient-depleted and nutrient-rich water media in aerated, intermediate and anaerobic conditions (oxygen saturation 96, 56 and 0%, respectively). A. baumannii survived in both media in all tested oxygen concentrations for 50 days. In nutrient-rich water survival of A. baumannii was lowest in anaerobic conditions, while in nutrient-depleted water there was no difference in survival regardless of oxygen availability. A. baumannii formed translucent small colony variants as the fast response (after 1 day) and dormant cells as the prolonged response (after 14 days) to anaerobic conditions. Transmission electron microscopy (TEM) images showed the outer membrane of coccobacillus dormant cells was up to four times thicker than in regular cells. Once in the environment, A. baumannii is able to survive regardless of the availability of dissolved oxygen, which represents a serious public health concern.
Lipoxygenase Inhibitors as Cancer Chemopreventives: Discovery, Recent Developments and Future Perspectives
Authors: Mahboubi-Rabbani Mohammad , Zarghi Afshin 
Published: December 2019

Background:
Leukotrienes (LTs) constitute a bioactive group of Polyunsaturated Fatty
Acid (PUFA) metabolites molded by the enzymatic activity of lipoxygenase (LO) and have a pivotal
role in inflammation and allergy. Evidence is accumulating both by in vitro cell culture experiments
and animal tumor model studies in support of the direct involvement of aberrant metabolism of arachidonic
acid (ACD) in the development of several types of human cancers such as lung, prostate,
pancreatic and colorectal malignancies. Several independent experimental data suggest a correlation
between tumoral cells viability and LO gene expression, especially, 5-lipoxygenase (5-LO). Overexpressed
5-LO cells live longer, proliferate faster, invade more effectively through extracellular matrix
destruction and activate the anti-apoptotic signaling mechanisms more intensively compared to the
normal counterparts. Thus, some groups of lipoxygenase inhibitors may be effective as promising
chemopreventive agents.

Methods:
A structured search of bibliographic databases for peer-reviewed research literature regarding
the role of LO in the pathogenesis of cancer was performed. The characteristics of screened papers
were summarized and the latest advances focused on the discovery of new LO inhibitors as anticancer
agents were discussed.

Results:
More than 180 papers were included and summarized in this review; the majority was about
the newly designed and synthesized 5-LO inhibitors as anti-inflammatory and anticancer agents. The
enzyme’s structure, 5-LO pathway, 5-LO inhibitors structure-activity relationships as well as the
correlation between these drugs and a number of most prevalent human cancers were described. In
most cases, it has been emphasized that dual cyclooxygenase-2/5-lipoxygenase (COX-2/5-LO) or
dual 5-lipoxygenase/microsomal prostaglandin E synthase-1 (5-LO/mPGES-1) inhibitors possess
considerable inhibitory activities against their target enzymes as well as potent antiproliferative effects.
Several papers disclosing 5-lipoxygenase activating protein (FLAP) antagonists as a new group
of 5-LO activity regulators are also subject to this review. Also, the potential of 12-lipoxygenase (12-
LO) and 15-lipoxygenase (15-LO) inhibitors as chemopreventive agents was outlined to expand the
scope of new anticancer agents discovery. Some peptides and peptidomimetics with anti-LT activities
were described as well. In addition, the cytotoxic effects of lipoxygenase inhibitors and their adverse
effects were discussed and some novel series of natural-product-derived inhibitors of LO was also
discussed in this review.

Conclusion:
This review gives insights into the novel lipoxygenase inhibitors with anticancer activity
as well as the different molecular pharmacological strategies to inhibit the enzyme effectively. The
findings confirm that certain groups of LO inhibitors could act as promising chemopreventive agents.
Co-expression Network Analysis Revealing the Potential Regulatory Roles of LncRNAs in Atrial Fibrillation
Authors: Shen Lishui , Shen Guilin , Lu Xiaoli , Ding Guomin , Hu Xiaofeng 
Published: December 2019

Background:
Atrial fibrillation (AF) is one of the most common heart arrhythmic disorders
all over the world. However, it is worth noting that the mechanism underlying AF is still dimness.

Methods:
In this study, we implemented a series of bioinformatics methods to explore the
mechanisms of lncRNAs underlying AF pathogenesis. The present study analyzed the public
datasets (GSE2240 and GSE115574) to identify differentially expressed long non-coding RNAs
(lncRNAs) and mRNAs in the progression of AF.

Results:
Totally, 71 differentially expressed lncRNAs and 390 DEGs were identified in AF.Next,
we performed bioinformatics analyses to explore the functions of lncRNAs in AF. Gene Ontology
(GO) analysis indicated that differentially expressed lncRNAs were involved in regulating multiple
key biological processes, such as cell cycle and signal transduction. Kyoto Encyclopedia of Genes
and Genomes (KEGG) pathway analysis demonstrated these lncRNAs were associated with the
regulation of MAPK and Wnt signaling pathways. Eight lncRNAs (RP5-1154L15.2, RP11-
339B21.15, RP11-448A19.1, RP11-676J12.4, LOC101930415, MALAT1, NEAT1, and PWAR6)
were identified to be key lncRNAs and widely co-expressed with a series of differentially expressed
genes (DEGs).

Conclusion:
Although further validation was still needed, our study may be helpful to elucidate the
mechanisms of lncRNAs underlying AF pathogenesis and providing further insight into identifying
novel biomarkers for AF.
Cardiovascular Effects of Micromeria graeca (L.) Benth. ex Rchb in Normotensive and Hypertensive Rats
Authors: Akdad Mourad , Eddouks Mohamed 
Published: December 2019

Aims:
The present study was performed in order to analyze the antihypertensive activity of
Micromeria graeca (L.) Benth. ex Rchb.

Background:
Micromeria graeca (L.) Benth. ex Rchb is an aromatic and medicinal plant belonging to
the Lamiaceae family. This herb is used to treat various pathologies such as cardiovascular disorders.
Meanwhile, its pharmacological effects on the cardiovascular system have not been studied.

Objective:
The present study aimed to evaluate the effect of aqueous extract of aerial parts of Micromeria
graeca (AEMG) on the cardiovascular system in normotensive and hypertensive rats.

Methods:
In this study, the cardiovascular effect of AEMG was evaluated using in vivo and in vitro
investigations. In order to assess the acute effect of AEMG on the cardiovascular system, anesthetized
L-NAME-hypertensive and normotensive rats received AEMG (100 mg/kg) orally and arterial blood
pressure parameters were monitored during six hours. In the sub-chronic study, rats were orally treated
for one week, followed by blood pressure assessment during one week of treatment. Blood pressure
was measured using a tail-cuff and a computer-assisted monitoring device. In the second experiment,
isolated rat aortic ring pre-contracted with Epinephrine (EP) or KCl was used to assess the vasorelaxant
effect of AEMG.

Results:
Oral administration of AEMG (100 mg/kg) provoked a decrease of arterial blood pressure
parameters in hypertensive rats. In addition, AEMG induced a vasorelaxant effect in thoracic aortic
rings pre-contracted with EP (10 μM) or KCl (80 mM). This effect was attenuated in the presence of
propranolol and methylene blue. While in the presence of glibenclamide, L-NAME, nifedipine or Indomethacin,
the vasorelaxant effect was not affected.

Conclusion:
This study showed that Micromeria graeca possesses a potent antihypertensive effect and
relaxes the vascular smooth muscle through β-adrenergic and cGMP pathways.
The HealthChain Blockchain for Electronic Health Records: Development Study
Authors: Xiao Yonggang , Xu Bin , Jiang Wenhao , Wu Yunjun 
Published: December 2019

Background
Health care professionals are required to maintain accurate health records of patients. Furthermore, these records should be shared across different health care organizations for professionals to have a complete review of medical history and avoid missing important information. Nowadays, health care providers use electronic health records (EHRs) as a key to the implementation of these goals and delivery of quality care. However, there are technical and legal hurdles that prevent the adoption of these systems, such as concerns about performance and privacy issues.

Objective
This study aimed to build and evaluate an experimental blockchain for EHRs, named HealthChain, which overcomes the disadvantages of traditional EHR systems.

Methods
HealthChain is built based on consortium blockchain technology. Specifically, three organizations, namely hospitals, insurance providers, and governmental agencies, form a consortium that operates under a governance model, which enforces the business logic agreed by all participants. Every peer node hosts an instance of the distributed ledger consisting of EHRs and an instance of chaincode regulating the permissions of participants. Designated orderers establish consensus on the order of EHRs and then disseminate blocks to peers.

Results
HealthChain achieves functional and nonfunctional requirements. It can store EHRs in a distributed ledger and share them among different participants. Moreover, it demonstrates superior features, such as privacy preservation, security, and high throughput. These are the main reasons why HealthChain is proposed.

Conclusions
Consortium blockchain technology can help to build new EHR systems and solve the problems that prevent the adoption of traditional systems.
Exploring Older Adults’ Beliefs About the Use of Intelligent Assistants for Consumer Health Information Management: A Participatory Design Study
Authors: Martin-Hammond Aqueasha , Vemireddy Sravani , Rao Kartik 
Published: December 2019

Background
Intelligent assistants (IAs), also known as intelligent agents, use artificial intelligence to help users achieve a goal or complete a task. IAs represent a potential solution for providing older adults with individualized assistance at home, for example, to reduce social isolation, serve as memory aids, or help with disease management. However, to design IAs for health that are beneficial and accepted by older adults, it is important to understand their beliefs about IAs, how they would like to interact with IAs for consumer health, and how they desire to integrate IAs into their homes.

Objective
We explore older adults’ mental models and beliefs about IAs, the tasks they want IAs to support, and how they would like to interact with IAs for consumer health. For the purpose of this study, we focus on IAs in the context of consumer health information management and search.

Methods
We present findings from an exploratory, qualitative study that investigated older adults’ perspectives of IAs that aid with consumer health information search and management tasks. Eighteen older adults participated in a multiphase, participatory design workshop in which we engaged them in discussion, brainstorming, and design activities that helped us identify their current challenges managing and finding health information at home. We also explored their beliefs and ideas for an IA to assist them with consumer health tasks. We used participatory design activities to identify areas in which they felt IAs might be useful, but also to uncover the reasoning behind the ideas they presented. Discussions were audio-recorded and later transcribed. We compiled design artifacts collected during the study to supplement researcher transcripts and notes. Thematic analysis was used to analyze data.

Results
We found that participants saw IAs as potentially useful for providing recommendations, facilitating collaboration between themselves and other caregivers, and for alerts of serious illness. However, they also desired familiar and natural interactions with IAs (eg, using voice) that could, if need be, provide fluid and unconstrained interactions, reason about their symptoms, and provide information or advice. Other participants discussed the need for flexible IAs that could be used by those with low technical resources or skills.

Conclusions
From our findings, we present a discussion of three key components of participants’ mental models, including the people, behaviors, and interactions they described that were important for IAs for consumer health information management and seeking. We then discuss the role of access, transparency, caregivers, and autonomy in design for addressing participants’ concerns about privacy and trust as well as its role in assisting others that may interact with an IA on the older adults’ behalf.

International Registered Report Identifier (IRRID)
RR2-10.1145/3240925.3240972
Internet of Things–Enabled Technologies for Weight Management in Children and Adolescents: Protocol for a Systematic Review
Authors: Lam Ching , Milne-Ives Madison , Van Velthoven Michelle Helena , Meinert Edward 
Published: December 2019

Background
Childhood obesity is a serious global issue, leading to increased medical spending on obesity-related diseases such as cardiovascular diseases and diabetes. There is a need for health care services that link health behavior to risk factors, such as diet and physical activity, and that provide better advice and feedback to users, which Internet of Things–enabled technologies could facilitate.

Objective
The objective of the systematic review will be to identify available Internet of Things–enabled technologies for weight management of children and adolescents (users younger than 18 years). It will also aim to understand the use, effectiveness, and feasibility of these technologies.

Methods
We will search the Medline, PubMed, Web of Science, Scopus, ProQuest Central, and IEEE Xplore Digital Library databases for studies published after 2010, using a combination of keywords and subject headings related to health activity tracking, youth, and Internet of Things. In addition, a Google search to identify grey literature will be conducted. Two authors will independently screen the titles and abstracts identified from the search and accept or reject the studies according to the study inclusion criteria. Any discrepancies will then be discussed and resolved. The quality of the included studies will be assessed using the Critical Appraisal Skills Programme (CASP) checklists. Data from included studies will be extracted into a predesigned form to identify the types of devices or apps, Internet of Things applications, and health outcomes related to weight management.

Results
A preliminary search on Medline returned 484 results. The publication of the final systematic review is expected in mid-2020.

Conclusions
The effectiveness and feasibility of physical activity trackers and consumer wearables for different patient groups have been well reviewed, but there are currently no published reviews that look into these technologies in the wider Internet of Things context. This review aims to address this gap by examining Internet of Things–enabled technologies that are designed for youth weight management and thus inform further research and clinical studies to reduce childhood obesity.

International Registered Report Identifier (IRRID)
PRR1-10.2196/16930