bluuebunny/crossref_metadata_2025_split huggingface dataset:
A heuristic model for collaborative practice – Part 2: An elaboration of theoretical perspectives and strategies in community mental health and substance abuse care
Authors: Sundet Rolf , Kim Hesook Suzie , Karlsson Bengt , Borg Marit , Sælør Knut Tore , Ness Ottar 
Published: April 2020

Abstract
Background Various models for collaborative practice in mental health care incorporating the perspectives of service-user participation and collaboration in the care have been developed. However, the emphasis in these practice models has not been on identifying specific features of “how” collaboration and service-user participation can occur and be nurtured. This suggests a need for a collaborative practice model that specifies essential strategies operationalizing the tenets of service-user participation and collaboration applicable in mental health and substance abuse (MHSA) care. Methods A double helix approach of coalescing theoretical ideas and empirical findings to develop a practice model that is applicable in MHSA practice. A theoretical analysis is carried out to identify the critical, foundational elements for collaborative practice in MHSA practice, and has identified the philosophical-theoretical orientations of Habermas’ theory of communicative action, Bakhtin’s dialogicality, and the philosophy of personhood as the foundational features of collaboration. This base is juxtaposed with the results of a qualitative meta-analysis of 18 empirical articles on collaboration in MHSA to advance a collaborative practice model specifically in the domain of service user/professional collaboration.Results “The collaborative, dialogue-based clinical practice model” (CDCP Model) for community mental health care is proposed, within the structure of four main components. The first specifies the framework for practice that includes person-centered care, recovery-orientation, and a pluralistic orientation and the second identifies the domains of collaboration as service user/professional collaboration, inter-professional collaboration, and service sector collaboration. The third identifies self-understanding, mutual understanding, and shared decision-making as the essential principles of collaboration. The fourth specifies interactive-dialogic processes, negotiated-participatory engagement processes, and negotiated-supportive processes as the essential strategies of collaboration applicable in service user/professional collaboration which were extracted in the empirical work. An illustration of the CDCP Model in a clinical case is given.
Isolation and Characterization of WUPyV in Polarized Human Airway Epithelial Cells
Authors: Wang Chao , Wei Tianli , Huang Yiman , Xie Zhiping , Song Jingdong , Chen Aijun , Zheng Lishu 
Published: April 2020

Abstract
Background Washington University polyomavirus (WUPyV) is a novel human polyomavirus detected in patient with acute respiratory infection. However, the relationship between WUPyV and respiratory diseases has yet to be established for lacking of a suitable in vitro culture system. Methods To isolate WUPyV with human airway epithelial (HAE) cells, the positive samples were incubated in HAE, and then the nucleic acid, VP1 protein and virions were detected using real-time PCR, immunofluorescence and electron microscopy respectively, and the whole genome sequence was obtained by Sanger sequencing. Results The result showed that WUPyV could replicate effectively in HAE cells and virions with typical polyomavirus characteristics could be observed. Additionally, the entire genome sequence of the isolated strain (BJ0771) was obtained and phylogenetic analysis indicated that BJ0771 belongs to gene cluster I. Conclusions Our findings demonstrated clinical WUPyV strain was successfully isolated for the first time in the world and this will help unravel the etiology and pathogenic mechanisms of WUPyV in respiratory infection diseases.
Effects of high temperature stress during anthesis and grain filling periods on photosynthesis, lipids and grain yield in wheat
Authors: Djanaguiraman Maduraimuthu , Narayanan Sruthi , Erdayani Eva , Prasad P.V. Vara 
Published: April 2020

Abstract
Background : Short episodes of high temperature (HT) stress during reproductive stages of development cause significant yield losses in wheat ( Triticum aestivum L.). Two independent experiments were conducted to quantify the effects of high temperature (HT) during anthesis and grain filling periods on photosynthesis, leaf lipidome, and yield traits in wheat. In experiment I, wheat genotype Seri82 was exposed to optimum temperature (OT; 22/14 °C; day/night) or HT (32/22 °C) for 14 d during anthesis stage. In experiment II, the plants were exposed to OT or HT for 14 d during grain filling stage. During the HT stress, chlorophyll index, thylakoid membrane damage, stomatal conductance, photosynthetic rate and leaf lipid composition were measured. At maturity, grain yield and its components were quantified. Results : HT stress during anthesis or grain filling stage decreased photosynthetic rate (17 and 25%, respectively) and grain yield plant -1 (29 and 44%, respectively), and increased thylakoid membrane damage (61 and 68%, respectively) compared to their respective control (OT). HT stress during anthesis or grain filling stage increased the levels of less unsaturated lipid species [36:5- monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG)]. However, at grain filling stage, HT stress decreased the levels of more unsaturated lipid species (36:6- MGDG and DGDG). There was a significant positive relationship between photosynthetic rate and grain yield plant -1 , and a negative relationship between thylakoid membrane damage and photosynthetic rate. Conclusions : The study suggests that maintaining thylakoid membrane stability, and seed-set percent and individual grain weight under HT stress can improve photosynthetic rate and grain yield, respectively.
Immune prognostic implications of PSMD14 and its associated genes signatures in hepatocellular carcinoma
Authors: Tian Chuan , Abudoureyimu Mubalake , Lin Xinrong , Zhou Hao , Chu Xiaoyuan , Wang Rui 
Published: April 2020

Abstract
Background PSMD14 played a vital roles initiation and progression of hepatocellular carcinoma (HCC). However, PSMD14 and its-related genes for the immune prognostic implications of HCC patients have rarely been analyzed. Therefore, we aimed to explore gene signatures and immune prognostic values of PSMD14 and its-related genes in HCC. Method Analyzed the expression of PSMD14 in multiple databases, and clinicopathologic characteristics associated with PSMD14 overall survival using Wilcoxon signed-ranktest, logistic and Cox regression, Kaplan-Meier method. An immune prognostic signature (including RBM45, PSMD1, OLA1, CCT6A, LCAT and IVD) was constructed and validated using the co-expression and cox regression analyses in TCGA, ICGC and TIMER datasets. Gene Set Enrichment Analysis (GSEA) was performed using TCGA data set. Results Increased PSMD14 expression in HCC was significantly associated with poor prognosis and clinicopathologic characteristics (grade, histologic stage, surgical approach and T stage, all p-values < 0.05). A total of six PSMD14-related genes were detected, which markedly related to overall survival and immune infiltrating levels in HCC patients. Using cox regression analysis, the PSMD14 and its-related genes were found to be an independent prognostic factor for HCC survival. Calibration curves confirmed good consistency between clinical nomogram prediction and actual observation. Immune prognostic model suggests that patients in the high‐risk group shown significantly poorer survival than patients in the low‐risk group. Conclusion We screened potential immune prognostic genes and constructed and verified a novel PSMD14-based prognostic model of HCC, which provides new potential prognostic biomarkers and therapeutic targets and lays a theoretical foundation for immunotherapy of HCC.
Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma
Authors: Li Ming , Gao Feng , Yu Xinfang , Zhao Qiung , Zhou Li , Liu Wenbin , Li Wei 
Published: April 2020

Abstract
Background: Overexpression of survivin plays a crucial role in the maintaining unlimited cell growth, apoptosis suppression, and correlates with poor prognosis in human malignancies. Methods: A natural product library was used for natural compound screening through MTS assay. The expression of survivin in oral squamous cell carcinoma (OSCC) and the inhibitory effect of xanthohumol (XN) on OSCC were examined through methods of anchorage-dependent and -independent growth assays, immunoblot, immunofluorescence, immunohistochemical staining, ubiquitination analysis, co-immunoprecipitation assay, CRISPR-Cas9-based gene knockout, and xenograft experiment. Results: Survivin is highly expressed in OSCC cells and patient-derived tissues, and required for OSCC cell growth in vitro and in vivo . With a natural compound screening, we identified that xanthohumol exhibited a significant anti-tumor effect against OSCC cells through inhibiting survivin protein. Xanthohumol suppressed anchorage-dependent and independent cell growth and delayed in vivo tumor development of OSCC cells. Xanthohumol inhibited the Akt-Wee1-CDK1 signaling, which in turn decreased survivin phosphorylation on Thr34, and facilitated E3 ligase Fbxl7-mediated survivin ubiquitination. Xanthohumol alone or in combination with radiation overcame radioresistance in OSCC xenograft tumors. Conclusion: Our findings indicate that targeting survivin for degradation might a promising strategy for OSCC treatment. Keywords: Oral squamous cell carcinoma; Xanthohumol; Ubiquitination; Fbxl7
Health-related publications on fragile states in the alert zone: a bibliometric analysis
Authors: Sweileh Waleed 
Published: April 2020

Abstract
Background Vulnerable and fragile settings is global health challenge. Assessing health research activity can help identify neglected health domains in fragile settings. The objective of the current study was to assess and describe health research activity on fragile states in the alert zone. Method A bibliometric method was applied using SciVerse Scopus. Research articles published on fragile states in the alert zone were retrieved and analyzed. The Fragile State Index (FSI) score was used for selection of states in the alert zone. The analysis was limited to one year; 2018. Results The search query found 2299 research articles giving an average of 2 research articles per one million people per year in the selected fragile states. The number of research articles per one million population was not significantly correlated (p=0.053; r= - 0.349) with FSI scores. However, it was significantly correlated with the extent of international research collaboration (P<0.01, r=065). Research on communicable diseases was the largest research domain (763 articles; 33.2%) followed by maternal/women’s health (430 articles; 18.7%), non-communicable diseases (291 articles; 12.7%), health system/policy (271 articles; 11.8%) and psychosocial and mental health (89; 3.9%). The top ten cited articles were mainly on infectious diseases, particularly on malaria and Lassa fever. Of all the retrieved documents, 727 (31.6%) research articles appeared in national/regional journals while the remaining appeared in international journals. The World Health organization was the most active funding organization for research on fragile states. Top ten active institutions were mainly based in fragile states with the lowest FSI score, specifically Ethiopia, Uganda, Nigeria, and Pakistan. Conclusion Research on fragile states was relatively low. Research on mental health and health system/policy should be encouraged. Collaboration and funding might help academic institutions in fragile states to make health problems in these countries more visible
Peer navigation for individuals with serious mental illness leaving jail: a randomized trial study protocol
Authors: Hailemariam Maji , Weinstock Lauren M , Johnson Jennifer E. 
Published: April 2020

Abstract
Background: Serious mental illness (SMI) is a prevalent public health problem affecting 25% of individuals in jail. Re-entry to the community following incarceration is a vulnerable time for justice-involved individuals with SMI. SMI requires prompt and ongoing access to mental health and other healthcare services.Methods: The study will: 1) develop a Mentoring And Peer Support (MAPS) intervention for post-release mental health and other service connection among jailed individuals with SMI, and 2) pilot-test the MAPS intervention to determine the feasibility and acceptability of the MAPS intervention. The primary outcomes will be to evaluate the feasibility and acceptability of the proposed recruitment methods and research design, of the intervention training methods, of delivering the enhanced peer-navigator and control interventions. Study samples include (focus groups, open trial), and a randomized pilot trial in a sample of 40 individuals with SMI re-entering the community after jail release. Secondary outcomes will include post-release enrollment in mental health, medical care, and substance use services. We will also evaluate reduction in psychiatric symptoms, improvements in functioning, adherence to psychiatric medications, fewer substance using days, fewer hospitalizations and suicide attempts, nights unstably housed, and time until rearrest.Discussion: This pilot study will evaluate the feasibility and acceptability of a peer navigation intervention for individuals with serious mental illness leaving jails. The study will serve as a formative work for a larger randomized controlled trial assessing the effectiveness of peer navigator intervention for (include the primary outcome) in this population.
Are supplemental appraisal/reimbursement processes needed for rare disease treatments? An international comparison of country approaches
Authors: Nicod Elena , Whittal Amanda , Drummond Mike , Facey Karen 
Published: April 2020

Abstract
BACKGROUND There is increasing recognition that conventional appraisal approaches may be unsuitable for assessing the value for money of rare disease treatments (RDTs). This research examines whether supplemental appraisal processes for RDTs are needed, and if so, what form should these take. A qualitative research design was used that included (1) documentation of country appraisal/reimbursement processes for RDTs via questionnaires, desk research and iterative interactions with country experts to produce country vignettes, and (2) a cross-country analysis of these processes to identify and characterise countries with supplemental processes for RDTs, and compare them to countries without supplemental processes. RESULTS Thirty-two of the 37 invited countries participated in this research. Forty-one percent (13/32) use supplemental processes for RDTs. Their level of integration within standard processes ranged from low to high, characterised by whether they are separate or partially separate from the standard process, adapted or accelerated standard processes, or standard processes that account for rarity. They are characterised by features implemented throughout the appraisal process. These features are mechanisms that allow application of different standards to assess the value of the medicine, support to the appraisal/decision-making process, overcome the issues of lack of cost-effectiveness, or exempt from part of/the full HTA process. They apply to ultra-RDTs and/or RDTs, and are often combined. They increase the likelihood of reimbursement by adjusting and/or foregoing part of the assessment process, or accepting to pay more for the same added benefit as for common conditions, which is likely to lead to accepting high prices. A large proportion of countries with standard processes include one or more of these features (formally or informally) or are discussing potential changes in their systems. CONCLUSIONS Results suggest revealed preferences to treat RDTs differently than conventional medicines. Some of the challenges around uncertainty and high price remain, but supplemental process features allow for more adapted and consistent decision-making. Many of these processes are new and countries continue to adjust as they gain experience. These results do not outline what an ideal process for RDTs looks like, but identify some key features that can be implemented to facilitate this process.
Randomized clinical trials in ANCA-associated vasculitis: a systematic analysis of the WHO - International Clinical Trials Registry Platform.
Authors: IUDICI Michele , Puéchal Xavier , Brigante Alejandro , Atal Ignacio , Gabay Cem 
Published: April 2020

Abstract
Background. The analysis of the main features of randomized controlled trials (RCTs) on ANCA-associated vasculitis (AAV) can inform future study design.Methods. We searched within the International Clinical Trials Registry Platform all registered RCTs on AAV from October 2008 to December 2018. Two reviewers selected studies according to pre-specified eligibility criteria. We retrieved information including countries, funding, design, sample sizes, eligibility criteria, primary outcomes (POs), and treatments.Results. Among the 40 RCTs identified, 22 (38%) were conducted in Europe, 29 (72%) in a single country, 14 (35%) were industry-funded. The median number of patients planned to enrol was 68 (IQR 36-138). Only 28% of RCTs targeted a single vasculitis and ANCA negative patients were not included in 40% of studies. Interventions investigated were mainly drugs given to induce (40%) or maintain (32%) remission. Eighty-five percent of POs were considered being ‘patient-important’, but discrepancies in definition of disease states such as remission or relapse were observed. Glucocorticoids use was part of the PO in <25% of studies. The number of trials targeting a single disease, non-industry funded, incorporating glucocorticoids in PO, as well as the planned sample size increased over time.Conclusion. Despite the important achievements in the field, the design of RCTs on AAV could be further improved.
Clinical effect of unilateral transcranial magnetic resonance-guided focused ultrasound thalamotomy in patients with essential tremor as evaluated by functional near-infrared spectroscopy
Authors: Kong Dongsheng , Zong Rui , Zhang Tingyu , Pan Longsheng , Yu Xinguang 
Published: April 2020

Abstract
Background: Transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) surgery is a noninvasive thermal ablation therapy for neurological conditions such as essential tremor (ET). However, most studies on the therapeutic mechanisms of this technique are limited to the visualization of brain structure and network activities with resting state functional magnetic resonance imaging. We aimed to investigate the effect of tcMRgFUS on the cortical level of the motor network using functional near-infrared spectroscopy (fNIRS).Results: Two sample paired t-tests revealed that only channel 6 (left primary motor and somatosensory cortices), and channel 45 (right dorsolateral prefrontal cortex) were significantly activated in the writing task after MRgFUS treatment compared to the task before MRgFUS treatment (CH6: t(6) = 3.42, p < 0.05, Cohen's d = 1.29; CH45: t(6) = 2.47, p < 0.05, Cohen's d = 0.93).Conclusions: We identified changes in relevant cortical activity after surgery and found that fNIRS can provide an important supplement to objective assessment of the clinical efficacy of tcMRgFUS.
Arthroscopic treatment of synovial chondromatosis of hip joint
Authors: Liu Yufeng , Li Ji , Ma Ning , An Mingyang , Gao Feng , Hu Bo , Zhang Boqing , Wang Zhigang , Liu Yujie , Li Chunbao 
Published: April 2020

Abstract
Purpose ：This retrospective study summarized the clinical, radiographic and arthroscopic manifestation of synovial chondromatosis (SC) of the hip, along with the post-operative effect to discuss the curative effect of arthroscopic management of hip SC. Methods : 21 patients underwent arthroscopic surgery from the same surgeon for hip SC were followed up for an average of 45 months. T-shaped capsulotomy was routinely performed in each case. Visual analog scale, range of motion, modified Harris Hip score and International Hip Outcome Tool score were collected preoperatively and at the time of the latest follow-up. All patients’ demographics, radiographs and arthroscopic images were collected to summarize and conclude the similarities and differences of their manifestation. Results : Large wedged clumps of loose bodies demonstrated distinguishable radiographic, arthroscopic appearance and demanded different surgical strategy. Postoperative scores were all significantly improved. One case of residual pain and two cases of residual loose bodies with no symptom related were reported at the final follow up. All but one patients were satisfied with the outcome. Conclusion : Arthroscopy treatment of hip SC with T-shaped capsulotomy has demonstrated good result in terms of clinical outcome score, recurrence rate and complication rate. On the basis of this study, we concluded the clinical performance of large wedged clumps of loose bodies of hip SC.
Rietveld refinement and diffuse phases transition of Ba1-XBixTi0.8Fe0.2O3 ceramics at x=0.00, 0.05, 0.10 and 0.15 prepared by solid state method.
Authors: Gouitaa Najwa , Taj-dine LAMCHARFI , BOUAYAD Mfadal , Farid ABDI , Haddad Mustapha 
Published: April 2020

Abstract
The effect of substitution of Baryum by Bismut in site A and titanium by iron in site A on structural, physical and electrical properties of Ba1-xBixTi0.80Fe0.20O3 ceramics at (x=0.00, 0.05, 0.10 and 0.15) was investigated by X-ray diffraction, Scaning Electron Microscopy (SEM) as well as dielectric characterizations. The crystal phase was studied by using rietveld refinement. The result of rietveld refinement of X-ray powders diffraction of Ba1-xBixTi0.80Fe0.20O3 shows that these compounds crystallize in tetragonal (P4mm) and hexagonal (P63mmc) for x=0.00 and 0.05 while at x=0.10 and 0.15 the hexagonal phase disappears and the tetragonal phase is stabilized. The structural parameters and the R-factors of these ceramics were succefully determined by the rietveld refinement. The Raman spectra confirms the disappearance of hexagonal phase in benefit of tetragonal phase as the Bi substitution increases. The dielectric measurements as function of temperature are studied and showed tree diffuse phase transitions transition from the ferroelectric rhombohedral phase to the ferroelectric orthorhombic TR-O phase and the second one is from the ferroelectric orthorhombic phase to the ferroelectric TO-T tetragonal phase. While the third one at high temperatures is the phase transition from the ferroelectric tetragonal phase to the paraelectric cubic phase Tm. These phases transition were displaced to the lower temperature with increasing of Bi substitution. And the value of dielectric permittivity increases gradually with increasing of Bi2+ contents. All these phase transitions showed a diffused phenomenon which can be well described by fitting the modified Ushino relation, 1/ε’r = 1/ε’r,max [ 1+ ((T-Tm)/2δ)γ]. The complex impedance Cole–Cole plots showed negative temperature coefficient of resistivity (NTCR) behavior of the Ba1-xBixTi0.80Fe0.20O3 for x=0.05 to 0.15 materials and decrease in grain and grain boundaries resistivity. The relaxation behavior in the test materials is found to be of Debye type.