bluuebunny/crossref_metadata_2025_split huggingface dataset:
Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature
Authors: Przybyla Magdalena , van Eersel Janet , van Hummel Annika , van der Hoven Julia , Sabale Miheer , Harasta Anne , Müller Julius , Gajwani Mehul , Prikas Emmanuel , Mueller Thomas , Stevens Claire H , Power John , Housley Gary D , Karl Tim , Kassiou Michael , Ke Yazi D , Ittner Arne , Ittner Lars M 
Published: April 2020

Abstract
Hyperphosphorylation and deposition of tau in the brain characterizes frontotemporal dementia and Alzheimer’s disease. Disease-associated mutations in the tau-encoding MAPT gene have enabled the generation of transgenic mouse models that recapitulate aspects of human neurodegenerative diseases, including tau hyperphosphorylation and neurofibrillary tangle formation. Here, we characterized the effects of transgenic P301S mutant human tau expression on neuronal network function in the murine hippocampus. Onset of progressive spatial learning deficits in P301S tau transgenic TAU58/2 mice were paralleled by long-term potentiation deficits and neuronal network aberrations during electrophysiological and EEG recordings. Gene-expression profiling just prior to onset of apparent deficits in TAU58/2 mice revealed a signature of immediate early genes that is consistent with neuronal network hypersynchronicity. We found that the increased immediate early gene activity was confined to neurons harbouring tau pathology, providing a cellular link between aberrant tau and network dysfunction. Taken together, our data suggest that tau pathology drives neuronal network dysfunction through hyperexcitation of individual, pathology-harbouring neurons, thereby contributing to memory deficits.
Longitudinal evaluation of the natural history of amyloid-β in plasma and brain
Authors: Burnham Samantha C , Fandos Noelia , Fowler Christopher , Pérez-Grijalba Virginia , Dore Vincent , Doecke James D , Shishegar Rosita , Cox Timothy , Fripp Jurgen , Rowe Christopher , Sarasa Manuel , Masters Colin L , Pesini Pedro , Villemagne Victor L 
Published: April 2020

Abstract
Plasma amyloid-β peptide concentration has recently been shown to have high accuracy to predict amyloid-β plaque burden in the brain. These amyloid-β plasma markers will allow wider screening of the population and simplify and reduce screening costs for therapeutic trials in Alzheimer’s disease. The aim of this study was to determine how longitudinal changes in blood amyloid-β track with changes in brain amyloid-β. Australian Imaging, Biomarker and Lifestyle study participants with a minimum of two assessments were evaluated (111 cognitively normal, 7 mild cognitively impaired, 15 participants with Alzheimer’s disease). Amyloid-β burden in the brain was evaluated through PET and was expressed in Centiloids. Total protein amyloid-β 42/40 plasma ratios were determined using ABtest® assays. We applied our method for obtaining natural history trajectories from short term data to measures of total protein amyloid-β 42/40 plasma ratios and PET amyloid-β. The natural history trajectory of total protein amyloid-β 42/40 plasma ratios appears to approximately mirror that of PET amyloid-β, with both spanning decades. Rates of change of 7.9% and 8.8%, were observed for total protein amyloid-β 42/40 plasma ratios and PET amyloid-β, respectively. The trajectory of plasma amyloid-β preceded that of brain amyloid-β by a median value of 6 years (significant at 88% confidence interval). These findings, showing the tight association between changes in plasma and brain amyloid-β, support the use of plasma total protein amyloid-β 42/40 plasma ratios as a surrogate marker of brain amyloid-β. Also, that plasma total protein amyloid-β 42/40 plasma ratios has potential utility in monitoring trial participants, and as an outcome measure.
Clinical Test Performance of a Rapid Point-of-Care Syphilis Treponemal Antibody Test: A Systematic Review and Meta-analysis
Authors: Bristow Claire C , Klausner Jeffrey D , Tran Anthony 
Published: April 2020

Abstract
We reviewed relevant syphilis diagnostic literature and conducted a meta-analysis to address the question, “What is the sensitivity and specificity of the Syphilis Health Check, a rapid qualitative test for the detection of human antibodies to Treponema pallidum.” The Syphilis Health Check is the only rapid syphilis test currently cleared by the Food and Drug Administration (FDA). We conducted a systematic review and a meta-analysis using Bayesian bivariate random-effects and fixed-effect models to create pooled estimates of sensitivity and specificity of the Syphilis Health Check. We identified 5 test evaluations published in the literature and 10 studies submitted to the FDA and for a Clinical Laboratory Improvement Amendments waiver application. The pooled sensitivity (95% CI) from the laboratory evaluations (n = 5) was 98.5% (92.1–100%), while pooled specificity was 95.9% (81.5–100.0%). The pooled sensitivity for prospective studies (n = 10) was 87.7% ( 71.8–97.2%), while pooled specificity was 96.7% (91.9–99.2%). Using nontreponemal supplemental testing, the sensitivity improved to a pooled sensitivity of 97.0% (94.8–98.6%). The Syphilis Health Check may provide accurate detection of treponemal antibody.
CRF01_AE and CRF01_AE Cluster 4 Are Associated With Poor Immune Recovery in Chinese Patients Under Combination Antiretroviral Therapy
Authors: Ge Zhangwen , Feng Yi , Li Kang , Lv Bowen , Zaongo Silvere D , Sun Jia , Liang Yanling , Liu Dan , Xing Hui , Wei Min , Ma Ping , Shao Yiming 
Published: April 2020

Abstract

Background
Human immunodeficiency virus type 1 (HIV-1) clades and clusters have different epidemic patterns and phenotypic profiles. It is unclear if they also affect patients’ immune recovery (IR) in combination antiretroviral therapy (cART).

Methods
We conducted a cohort study on 853 patients under cART for evaluating the impacts of viral factor on host IR. We used generalized estimating equations for factors affecting CD4 recovery, Kaplan-Meier curves for probability of achieving IR, and Cox hazards model for factors influencing IR capability.

Results
Besides low baseline CD4 and old age, CRF01_AE and its cluster 4 were independently associated with lower CD4 cell level (P ≤ .003), slower IR (P ≤ .022), fewer patients (P &lt; .001), and longer time achieving IR (P &lt; .001), compared with CRF07_BC and CRF01_AE cluster 5. Higher percentage of CXCR4 (X4) viruses in the CRF01_AE and cluster 4–infected patients, compared with their respective counterparts (P &lt; .001), accounted for the poor IR in infected patients (P &lt; .001). Finally, we revealed that greater X4 receptor binding propensity of amino acids was exhibited in CRF01_AE clade (P &lt; .001) and its cluster 4 (P ≤ .004).

Conclusions
Our study demonstrates that the CRF01_AE clade and cluster are associated with poor IR in patients under cART, which is ascribed to a high proportion of viruses with X4 tropism. HIV-1 genotyping and phenotyping should be used as a surveillance tool for patients initiating cART. CCR5 inhibitors should be used with caution in regions with high prevalence of X4 viruses.
Pulmonary Tuberculosis Disease Among Immigrant Detainees: Rapid Disease Detection, High Prevalence of Asymptomatic Disease, and Implications for Tuberculosis Prevention
Authors: Boardman Nicole J , Moore Tiffany , Freiman Jennifer , Tagliaferri Geri , McMurray Dakota , Elson Diana , Lederman Edith 
Published: April 2020

Abstract

Background
Rapid screening for tuberculosis (TB) disease at intake into immigrant detention facilities allows for early detection and treatment. Detention facilities with United States Immigration and Customs Enforcement (ICE) Health Service Corps (IHSC) medical staffing utilize chest radiography and symptom screening as the primary screening for pulmonary TB (PTB) disease. This analysis describes the demographic, clinical, and microbiological characteristics of individuals identified with TB disease at these facilities.

Methods
We conducted a retrospective analysis to describe the population of immigrant detainees identified via chest radiography with PTB disease between 1 January 2014 and 31 December 2016 at facilities with IHSC medical staffing. We collected demographic variables, clinical presentation, diagnostic testing results, and microbiological findings. We generated descriptive statistics and examined univariate and multivariate associations between the variables collected and symptomatic status.

Results
We identified 327 patients with confirmed PTB disease (incidence rate, 92.8 per 100 000); the majority of patients were asymptomatic (79.2%) at diagnosis. Adjusting for all other variables in the model, the presence of cavitary lesions, acid-fast bacillus smear positivity, and multilobar presentation were significantly associated with symptomatic status. Among all patients identified with TB disease who had a tuberculin skin test (TST) result recorded, 27.2% were both asymptomatic and TST negative, including those with smear-positive disease.

Conclusions
Asymptomatic PTB disease is a significant clinical entity among immigrant detainees and placement in a congregate setting calls for aggressive screening to prevent transmission. Early identification, isolation, and treatment of TB disease benefit not only the health of the patient, but also the surrounding community.
A Tool for Early Prediction of Severe Coronavirus Disease 2019 (COVID-19): A Multicenter Study Using the Risk Nomogram in Wuhan and Guangdong, China
Authors: Gong Jiao , Ou Jingyi , Qiu Xueping , Jie Yusheng , Chen Yaqiong , Yuan Lianxiong , Cao Jing , Tan Mingkai , Xu Wenxiong , Zheng Fang , Shi Yaling , Hu Bo 
Published: April 2020

AbstractBackgroundBecause there is no reliable risk stratification tool for severe coronavirus disease 2019 (COVID-19) patients at admission, we aimed to construct an effective model for early identification of cases at high risk of progression to severe COVID-19.MethodsIn this retrospective multicenter study, 372 hospitalized patients with nonsevere COVID-19 were followed for &gt; 15 days after admission. Patients who deteriorated to severe or critical COVID-19 and those who maintained a nonsevere state were assigned to the severe and nonsevere groups, respectively. Based on baseline data of the 2 groups, we constructed a risk prediction nomogram for severe COVID-19 and evaluated its performance.ResultsThe training cohort consisted of 189 patients, and the 2 independent validation cohorts consisted of 165 and 18 patients. Among all cases, 72 (19.4%) patients developed severe COVID-19. Older age; higher serum lactate dehydrogenase, C-reactive protein, coefficient of variation of red blood cell distribution width, blood urea nitrogen, and direct bilirubin; and lower albumin were associated with severe COVID-19. We generated the nomogram for early identifying severe COVID-19 in the training cohort (area under the curve [AUC], 0.912 [95% confidence interval {CI}, .846–.978]; sensitivity 85.7%, specificity 87.6%) and the validation cohort (AUC, 0.853 [95% CI, .790–.916]; sensitivity 77.5%, specificity 78.4%). The calibration curve for probability of severe COVID-19 showed optimal agreement between prediction by nomogram and actual observation. Decision curve and clinical impact curve analyses indicated that nomogram conferred high clinical net benefit.ConclusionsOur nomogram could help clinicians with early identification of patients who will progress to severe COVID-19, which will enable better centralized management and early treatment of severe disease.
Physiological indicators of habitat quality for a migratory songbird breeding in a forest invaded by non-native Japanese barberry (Berberis thunbergii)
Authors: Seewagen Chad L , Slayton Eric J , Smith Pagano Susan 
Published: April 2020

Abstract
Non-native, invasive plants can impact birds by altering food sources, nesting substrates and other critical resources. Japanese barberry (Berberis thunbergii) is one of the most invasive, non-native woody plants in in the northeastern USA, and yet almost nothing is known about its effects on birds or other wildlife. To investigate individual-level impacts of Japanese barberry on a forest-breeding bird, we compared food abundance (leaf-litter arthropod biomass) and the physiological condition of territorial male ovenbirds (Seiurus aurocapilla) between areas of a forest preserve in New York State that had high or low densities of Japanese barberry. We used haemoglobin and plasma triglyceride concentrations to indicate energetic condition, plasma uric acid and total plasma protein levels to indicate diet quality, and heterophil to lymphocyte ratios to indicate chronic stress. We found no difference in arthropod biomass between ovenbird territories that were heavily invaded by or relatively free of Japanese barberry. Perhaps largely as a result, we found no relationship between Japanese barberry density and any of our five haematological condition indices. There was also no difference in body mass, body size or age ratio between ovenbirds nesting in areas with low or high densities of Japanese barberry to suggest that relatively uninvaded forest patches were in greater demand and acquired by the most dominant individuals. Our results indicate that Japanese barberry does not reduce habitat quality for breeding male ovenbirds in a way that affects their prey abundance or physiological condition, but we caution that other species of birds and other aspects of habitat quality could be affected differently. We encourage future research on additional bird species and the effects of Japanese barberry on factors such as diet composition, pairing and nesting success and post-fledging survival to improve science-based decision-making about the extent to which conservation resources should be applied towards Japanese barberry control.
The Risk of SARS-CoV-2 in Immunosuppressed IBD Patients
Authors: Higgins Peter D R , Ng Siew , Danese Silvio , Rao Krishna 
Published: April 2020

AbstractThis is a rapid review of the risk of infection with SARS-CoV-2, the risk of symptomatic cases of COVID-19, and the severity of these cases in IBD patients. Guidance on how to manage IBD patients at risk for infection, and IBD patients after infection is provided. The prevention of infection in both patients and health care providers by reducing elective visits and procedures, utilizing telemedicine, and social isolation is also emphasized to maintain health care services for IBD patients during a growing pandemic.
Agricultural Returns to Labour and the Origins of Work Ethics
Authors: Fouka Vasiliki , Schläpfer Alain 
Published: April 2020

AbstractWe examine the historical determinants of differences in preferences for work across societies today. Our hypothesis is that a society’s work ethic depends on the role that labour has played in it historically, as an input in agricultural production: societies that have for centuries depended on the cultivation of crops with high marginal returns to labour effort will work longer hours and develop a preference for working hard. We formalise this prediction in the context of a model of endogenous preference formation, with altruistic parents who can invest in reducing their offsprings’ disutility from work. To empirically found our model, we construct an index of potential agricultural labour intensity, that captures the suitability of a location for the cultivation of crops with high estimated marginal returns to labour in their production. We find that this index positively predicts work hours and attitudes towards work in contemporary European regions. We investigate various mechanisms of persistence, including cultural transmission, as well as a society’s production structure and institutions.
Sex Chromosome Evolution: So Many Exceptions to the Rules
Authors: Furman Benjamin L S , Metzger David C H , Darolti Iulia , Wright Alison E , Sandkam Benjamin A , Almeida Pedro , Shu Jacelyn J , Mank Judith E 
Published: April 2020

AbstractGenomic analysis of many nonmodel species has uncovered an incredible diversity of sex chromosome systems, making it possible to empirically test the rich body of evolutionary theory that describes each stage of sex chromosome evolution. Classic theory predicts that sex chromosomes originate from a pair of homologous autosomes and recombination between them is suppressed via inversions to resolve sexual conflict. The resulting degradation of the Y chromosome gene content creates the need for dosage compensation in the heterogametic sex. Sex chromosome theory also implies a linear process, starting from sex chromosome origin and progressing to heteromorphism. Despite many convergent genomic patterns exhibited by independently evolved sex chromosome systems, and many case studies supporting these theoretical predictions, emerging data provide numerous interesting exceptions to these long-standing theories, and suggest that the remarkable diversity of sex chromosomes is matched by a similar diversity in their evolution. For example, it is clear that sex chromosome pairs are not always derived from homologous autosomes. In addition, both the cause and the mechanism of recombination suppression between sex chromosome pairs remain unclear, and it may be that the spread of recombination suppression is a more gradual process than previously thought. It is also clear that dosage compensation can be achieved in many ways, and displays a range of efficacy in different systems. Finally, the remarkable turnover of sex chromosomes in many systems, as well as variation in the rate of sex chromosome divergence, suggest that assumptions about the inevitable linearity of sex chromosome evolution are not always empirically supported, and the drivers of the birth–death cycle of sex chromosome evolution remain to be elucidated. Here, we concentrate on how the diversity in sex chromosomes across taxa highlights an equal diversity in each stage of sex chromosome evolution.
Homological Stability for Spaces of Commuting Elements in Lie Groups
Authors: Ramras Daniel A , Stafa Mentor 
Published: April 2020

AbstractIn this paper, we study homological stability for spaces $\textrm{Hom}({{\mathbb{Z}}}^n,G)$ of pairwise commuting $n$-tuples in a Lie group $G$. We prove that for each $n\geqslant 1$, these spaces satisfy rational homological stability as $G$ ranges through any of the classical sequences of compact, connected Lie groups, or their complexifications. We prove similar results for rational equivariant homology, for character varieties, and for the infinite-dimensional analogues of these spaces, $\textrm{Comm}(G)$ and $B_{\textrm{com}} G$, introduced by Cohen–Stafa and Adem–Cohen–Torres-Giese, respectively. In addition, we show that the rational homology of the space of unordered commuting $n$-tuples in a fixed group $G$ stabilizes as $n$ increases. Our proofs use the theory of representation stability—in particular, the theory of $\textrm{FI}_W$-modules developed by Church–Ellenberg–Farb and Wilson. In all of the these results, we obtain specific bounds on the stable range, and we show that the homology isomorphisms are induced by maps of spaces.
Epidemiology of Seasonal Coronaviruses: Establishing the Context for the Emergence of Coronavirus Disease 2019
Authors: Nickbakhsh Sema , Ho Antonia , Marques Diogo F P , McMenamin Jim , Gunson Rory N , Murcia Pablo R 
Published: April 2020

AbstractPublic health preparedness for coronavirus (CoV) disease 2019 (COVID-19) is challenging in the absence of setting-specific epidemiological data. Here we describe the epidemiology of seasonal CoVs (sCoVs) and other cocirculating viruses in the West of Scotland, United Kingdom. We analyzed routine diagnostic data for &gt;70 000 episodes of respiratory illness tested molecularly for multiple respiratory viruses between 2005 and 2017. Statistical associations with patient age and sex differed between CoV-229E, CoV-OC43, and CoV-NL63. Furthermore, the timing and magnitude of sCoV outbreaks did not occur concurrently, and coinfections were not reported. With respect to other cocirculating respiratory viruses, we found evidence of positive, rather than negative, interactions with sCoVs. These findings highlight the importance of considering cocirculating viruses in the differential diagnosis of COVID-19. Further work is needed to establish the occurrence/degree of cross-protective immunity conferred across sCoVs and with COVID-19, as well as the role of viral coinfection in COVID-19 disease severity.
Keyboard-Based Protocol for Typing Algebraic Expressions
Authors: Fajardo-Flores Silvia , Pulido J R G , Andrade-Aréchiga María 
Published: April 2020

Abstract
Writing mathematical contents on digital format is more common every day. The usual method is to use WYSIWYG (What You See Is What You Get) equation editors included in mainstream text editors. However, this method requires a good deal of interaction with formula templates and the use of a pointing device. While this type of equation editors is accessible to users without visual disabilities, they present barriers for users with visual disability (UWVDs). Keyboard-based equation editors should promote not only inclusion but also an acceptable performance for sighted and non-sighted users. In this article, we analyze the efficiency of the typing protocol of the Algebra Editor, an accessible keyboard-based equation editor prototype, with sighted users. Results suggest that the protocol allows typing approximately 60 characters per minute. We also analyze the type and frequency of errors made by participants and suggest improvements to the protocol, derived from the findings. These results can be used as a reference to compare the efficiency of the protocol with non-sighted users and with other equation editors in future studies.
Ethyl Formate as a Methyl Bromide Alternative for Phytosanitary Disinfestation of Imported Banana in Korea With Logistical Considerations
Authors: Park Min-Goo , Park Chung-Gyoo , Yang Jeong-Oh , Kim Gil-Hah , Ren Yonglin , Lee Byung-Ho , Cha Dong H 
Published: April 2020

Abstract
Methyl bromide (MB) use for quarantine and phytosanitary purposes is being phased out. Several effective MB alternatives have been identified depending on the target system. Industry commitment for the shift to new technologies will depend not only on the efficacy of alternatives but also on their compatibility and integrability into existing operations. We compared the efficacy of MB and ethyl formate (EF) for disinfestation of Planococcus citri (Risso) (Hemiptera: Pseudococcidae) as a representative surface pest on banana and evaluated whether EF fumigation is compatible with the current packaging materials and loading ratio used by the South Korean banana import industry. Fumigation trials with P. citri adults and eggs showed that EF was at least as effective as MB at the EF and MB concentrations recommended under the current phytosanitary disinfestation guidelines. From a logistical standpoint, EF gas could not effectively penetrate plastic bagging typically used in banana cartons during commercial shipping. Also, EF sorption to bananas and packing materials (used as cushioning inside bagging) further lowered realized EF concentrations around bananas. These reductions in EF concentration translated into reduced mortality of P. citri eggs, indicating that despite similar efficacy of MB and EF for controlling P. citri, further consideration and optimization of other industry logistics such as packaging and loading ratio is necessary to enhance the adoption of this MB alternative.