bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the sensitivity of pathogens of purulent-inflammatory processes of the mediastinum to modern antiseptics
Authors: Shaprynskyi V.O. , Rymsha O.V. , Mitiuk B.O. , Vovk I.M. , Nazarchuk S.A. , Khodakivskyi M.A. , Ivanova M.O. 
Published: May 2020

Annotation. A well-chosen tactic for the prevention and treatment of infectious complications in patients with purulent-inflammatory processes of the mediastinum is important in reducing the colonization of the biotope by pathogens, contributes to the reduction of inflammation and accelerates recovery. The aim of our work was to conduct a comparative study of the antimicrobial efficacy of antiseptic drugs (decasan, myramistinum, chlorhexidine, povidone iodine and polyhexamethylene guanidine) on 278 clinical strains of microorganisms (S. aureus, E. coli, K. pneumoniae, Enterobacter spp.), which cause purulent-inflammatory complications of the mediastinum in patients. For the comparative characterization of the antimicrobial action, the method of double dilutions was used; calculated antiseptic activity index (AAI); a quantitative suspension test was performed to evaluate the decontamination effect of antiseptics. Standard methods of descriptive statistics and special and office programs “STATISTICA 6.0”, “Microsoft Excel 2010” were used. Staphylococci showed the highest level of sensitivity to most of the antiseptics under study. The mean MBSC values of S. aureus clinical strains for decasan, myramistinum, chlorhexidine was respectively 1.75±1.27 µg/ml, 3.25±2.27 µg/ml, and 5.53±3.74 µg/ml. The AAI of myramistinum and chlorhexidine before the Pseudomonas was 4.5, which is the threshold for clinical activity. The clinical activity of a solution of povidone iodine against infections caused by P. aeruginosa is doubtful, based on the activity level of 2.6. The studied antiseptics provided a full decontamination effect against most strains at 5 min exposure, the decontamination effect lasted for 15 min, followed by 30 min. There were found single microorganisms, the number of which gradually increased and after 1 hour reached 1.9×104 and 1.5×102 CFU/ml, respectively. The high sensitivity of gram-positive and gram-negative pathogens to decasan and polyhexamethylene guanidine hydrochloride substantiates their high antimicrobial effectiveness and opens wide prospects for their use in the prevention and treatment of infectious complications in modern conditions.
Prospects for the use of silver nanoparticles for the creation of composite dental materials with antimicrobial properties
Authors: Pereshyvailo O. , Holubnycha V. , Korniienko V. 
Published: May 2020

Annotation. Due to the uncontrolled use of antibiotics, the issue of antibiotic resistance has become vitally important. Search the alternative antimicrobials preparation is urgent question. Despite significant achievements in dentistry, the quality of root canals endodontic treatment remains relevant issue. Enterococcus faecalis is one of the ESKAPE group pathogen as well as one of the most common causative agents of intracanal caries. Ag nanoparticles (AgNPs) have shown high efficacy against several polyresistant strains. Therefore, the purpose of our study was to evaluate the possibility of AgNPs using to create composite dental materials with antimicrobial activity. Statistical processing of the obtained results was performed using the software package for statistical data processing Graph Pud Prism 8 with the definition of the Student's criterion. The antibacterial effect of Ag NPs was evaluated against the clinical strain of E. faecalis by determining the minimum inhibitory concentration (serial dilution method) and the minimum bactericidal concentration (direct inoculation of the microorganism from liquid onto solid media). The influence of AgNPs on the multiplication of the bacterial population and on the processes of biofilm formation were investigated. The MIC and MBC were 2.5 µg / ml. Time-kill curve of E. faecalis strain indicates the need for prolonged contact of microorganisms with the nanosilver preparation and reflect a gradual decrease in the number of bacteria in the sample. AgNPs inhibit the formation of biofilms in the early stages and effectively affect 3-days biofilms. The action of the silver nanoparticles at the initiation stage reduced the total volume of the unformed biofilm by 2 times at concentrations of 10 and 20 MICs. The inhibitory effect of silver on the formed 3-day biofilm was dose-dependent and increased with increasing concentration. The obtained results show AgNPs inhibit the growth and reproduction of planktonic and film forms of E. faecalis and can be used to create dental composite with antimicrobial activity.
The outcome of Daclatasvir and low dose Sofosbuvir therapy in end-stage renal disease patients with hepatitis C virus infection
Authors: Mostafi M. , Jabin M. , Chowdhury Z. , Khondoker M.U. , Ali S.M. , Tamanna R. , Rezwan R. , Alomgir S.B. 
Published: May 2020

Rapid progression of chronic kidney disease (CKD) is seen in patients with hepatitis C virus (HCV) infection compared with uninfected patients. Despite the high efficacy of direct-acting antivirals (DAAVs), their cost represents a limiting factor to their use in developing countries.
Aim. This study aimed to evaluate the efficacy of low dose Sofosbuvir along with Daclatasvir in the management of HCV infection in end-stage renal disease (ESRD) patients.
Methods. A total of 82 HCV positive patients on ESRD were included in this study. The patients were observed for six months without antiviral drugs. Patients who remained seropositive were divided into two groups. The first group included 26 (37%) patients who were treated with half-dose Sofosbuvir 200 mg and Daclatasvir 60 mg and the second group consisted of 44 (63%) patients who have been treated with full-dose Sofosbuvir 400 mg and Velpatasvir 100 mg irrespective of HCV infection genotype for 12 weeks also.
Results. 12 (14%) patients became seronegative spontaneously. All patients (100%) of both groups achieved sustained virological response with undetectable HCV RNA in 12 weeks of the treatment. There were nonsignificant gastrointestinal side effects in the full dose Sofosbuvir group. All patients tolerated the DAAs well. No patient discontinued antiviral therapy due to side effects
Conclusion. In this study, the spontaneous seroconversion of HCV was 14%. Low-dose Sofosbuvir along with Daclatasvir was safe and as effective as full-dose Sofosbuvir and Velpatasvir in the treatment of HCV in ESRD patients. Low-dose Sofosbuvir regimen can be recommended for HCV infection treatment in ESRD patients.
Prevalenceof abdominal aortic aneurysm among stage 3-4 chronic kidney disease patients aged 55 years and older
Authors: Karaarslan Cengiz O. , Nergizoglu G. 
Published: May 2020

The risk of cardiovascular disease begins to increase from the early stages of chronic kidney disease (CKD). Abdominal aortic aneurysms are the most common arterial aneurysms of peripheral arterial diseases. The frequency of abdominal aortic aneurysm varies according to the population studied. This study aimed to determine the prevalence of abdominal aortic aneurysm in patients with stage 3-4 CKD and investigate CKD is a risk factor for abdominal aortic aneurysm formation.
Methods. Patients aged 55 years and older who were followed up in the internal medicine outpatient clinics were enrolled. Two hundred CKD patients with glomerular filtration rates between 15-59 mL/min per 1.73 m2 were included in the study group, and 110 patients with glomerular filtration rates of 60 mL/min per 1.73 m2 or above were assigned to the control group. An ultrasonography device with a 3.5 MHz probe was used for screening. Abdominal aortic diameters of 3 cm and above were accepted as abdominal aortic aneurysms.
Results. Eighteen patients in the study group (9%) and four in the control group (3.6%) had an abdominal aortic aneurysm. The prevalence of abdominal aortic aneurysms was higher in the CKD group. However, the difference was not statistically significant (p=0.078). Moreover, the median aortic diameter was 21.8 mm (14-44 mm) in the study group, compared to 21.0 mm (14-46 mm) in the control group. The prevalence of the abdominal aortic aneurysm was 14.9% in stage 4 CKD patients and 6% in stage 3 CKD patients (p=0.038).
Conclusion. An abdominal aortic aneurysm is more common in patients with CKD although it does not reach statistical significance. The median aortic diameter was significantly wider in CKD patients compared to the control group . The prevalence of abdominal aortic aneurysm increased with an increase in the CKD stage .
Renal artery stenosis: the challenging in diagnosis and therapy
Authors: Dewi Ivana P. , Dewi Kristin P. , Mardiana N. 
Published: May 2020

Hypertension is still the most prevalent non-communicable diseases in Indonesia. Renovascular hypertension is one type of secondary hypertension. It is commonly caused by the presence of renal artery stenosis (RAS). Whereas, atherosclerosis (ARAS) and fibromuscular disease (FMD) are the most common causes of RAS. Early diagnosis is necessary because it has the potential to be cured by eliminating stenosis of the renal artery. However, the signs and symptoms of renovascular hypertension are not specific. The supporting examination to diagnose RAS is also expensive. So, screening in the population at risk is needed. The examinations to prove the presence of RAS are arteriography, captopril renogram, renal ultrasonography, renal Doppler ultrasonography, magnetic resonance angiography (MRA), and computed angiographic tomography (CTA).
Until now, three therapeutic modalities can be selected in the management of renovascular hypertension; pharmacological therapy, surgical intervention, percutaneous intervention angioplasty with and without stenting. This narrative review summarizes the literature focused on the diagnosis and therapy of RAS.
Air Pollution and Nasal Mucociliary Clearance Time among Urban and Rural Residents in Two Philippine Communities
Authors: Joson Soraya , Laxamana Joman 
Published: May 2020

ABSTRACT
Objective: To measure the nasal mucociliary clearance (NMC) time among adults residing in two Philippine communities with different air quality indices using the saccharin and methylene blue test.
Methods:
Design: Cross-Sectional Study
Setting: Diliman, Quezon City and Puerto Princesa, Palawan
Participantss: Fifty (50) participants, 25 residing in an urban city with fair air quality index and 25 residing in a rural province with good air quality index.
Results: The mean NMC time of the urban group was 22.15±12.68 mins and was significantly longer than the NMC time of the rural group which was 5.29±2.87mins; t(48) = 6.643, p<0.0001).
Conclusion: Increased air pollution may be associated with significant prolongation of nasal mucociliary clearance time among urban residents with fair quality air index compared to rural residents with good quality air index.
Keywords: nasal mucociliary clearance, naso mucociliary clearance time, air pollution, air quality index, saccharin test, methylene blue
Prognostic Value of Thyroidectomy and Tracheostomy in Anaplastic Thyroid Carcinoma
Authors: Garcia Carlo Victorio , Cabungcal Arsenio Claro , Pontejos Alfredo Quintin 
Published: May 2020

ABSTRACT
Objective: To determine the prognostic value of surgical interventions done among patients with anaplastic thyroid carcinoma (ATC)
Methods: A five-year retrospective chart review of 25 patients was done and baseline characteristics determined. Patients discharged alive as of the time of last chart entry were followed up by phone interview or personal visit. Overall survival was the main outcome measure which was plotted as Kaplan-Meier estimates and compared via log-rank test. The incidence of complications surrounding tracheostomy and thyroidectomy were also noted.
Methods:
Design: Ambispective Cohort Study
Setting: Tertiary National University Hospital
Participants: All private and public (charity) patients seen at the wards or clinics diagnosed with ATC via fine needle cytology or tissue histopathology.
Results: All patients presented with either stage IV-B or stage IV-C disease. A significant difference in survival curves was noted when comparing between the two stages (p<.05). Subgroup analysis per stage revealed no significant difference in overall survival when comparing patients who did not undergo surgery, those who underwent tracheostomy or those who underwent thyroidectomy for both IV-B (p=.244) or IV-C (p=.165) disease. The incidence of complications for tracheostomy was 60%, the most common being mucus plugging. For thyroidectomy, the incidence of complications was 80% with hypocalcemia being the most common> <.05). Subgroup analysis per stage revealed no significant difference in overall survival when comparing patients who did not undergo surgery, those who underwent tracheostomy or those who underwent thyroidectomy for both IV-B (p=.244) or IV-C (p=.165) disease. The incidence of complications for tracheostomy was 60%, the most common being mucus plugging. For thyroidectomy, the incidence of complications was 80% with hypocalcemia being the most common.
Conclusion: The current available data fails to demonstrate any significant survival advantage of tracheostomy or thyroidectomy when performed among similarly staged patients.
Keywords: anaplastic thyroid cancer; thyroidectomy; tracheostomy; survival
Bilateral Facial Nerve (Bell’s) Palsy in a 24-Year-Old Woman: A Case Report
Authors: Tolentino Camille , Cruz Emmanuel Tadeus 
Published: May 2020

ABSTRACT
Objective: To report a case of acute bilateral facial nerve palsy in a 24-year-old woman and to present the differential diagnoses, pathophysiology, management and prognosis
Methods:
Design: Case study
Setting: Tertiary Private Hospital
Patient: One (1)
Result: A 24-year-old woman with fever, joint pains, cough, chest pain, difficulty ambulating and progressive facial muscle weakness was diagnosed with rheumatic fever. Bilateral facial nerve paralysis was noted, and Electromyography-Nerve Conduction Velocity (EMG-NCV) testing with special facial nerve study revealed abnormal facial nerve and blink reflex studies while EMG-NCV of the upper and lower limbs were normal. Audiometry and MRI of the brain and facial nerve were normal while Schirmer’s Test showed decreased tearing in both eyes. The rheumatic fever resolved within 5 days of antibiotics, while Prednisone and physiotherapy resulted in improvement of facial paralysis from House Brackmann V to House Brackmann II-III over a period of 6 months.
Conclusion: Idiopathic facial paralysis or Bell’s Palsy is the most common cause of acute unilateral facial paralysis while bilateral facial nerve paralysis is a rare condition. Patients with facial palsy should undergo appropriate diagnostics to determine the underlying condition and to facilitate prompt management.
Keywords: facial paralysis, idiopathic; Bell’s palsy
GLOBAL SCRUTINY OF INDIA'S FIGHT AGAINST CORONA
Authors: Sanghamitra Dash  
Published: May 2020

India's relative success in fighting corona pandemic makes the concerned observers inquisitive of global strategic canvas, positional strengths and implementation challenges that have emerged for India. An attempt to respond to the threefold query is made in this brief analysis.
Keywords: India, Corona, Public Health, Ancient Therapy, Globalisation
Use of Copper as a Converter Catalyst on Motorcycle Exhaust to Reduce HC (Hidrocarbon) Gas Emissions
Authors: Juliardi AR Naniek Ratni , Wicaksono Dimas Hafiiz 
Published: May 2020

The increasing number of vehicles especially in Surabaya means resulting in congestion in light traffic and there are a lot of gas such as CO, CO2, SOx, NOx and HC which produced by motorcycles and other vehicles. It has a big impact for the living things health and needs a specific studies. Copper catalyst design is the most effective in reducing HC motor vehicle gas. The purpose of this study is using a copper catalyst design method that is varied with engine speed (rpm) 1000, 3000, 5000, 8000, type of fuel and using the number of skates 1, 3, 5. The best result of HC gas reduction from the design with skat 5 at rpm 8000 with premium used of 41,5 % from 171 ppm to 100 ppm. This best condition (8000 rpm, 5 skates) uses premium with 88 octan number, pertalite type fuel with 90 octane number, then use the pertamax with 92 octane number. The HC gas results are 6 ppm, 72 ppm and 42 ppm.
Розрахункова оцінка втомної міцності зміцнених зубів зубчастих коліс при згині
Authors: Kravchuk V. , Nemchuk O. , Lymarenko O. 
Published: May 2020

Розглянуто особливості оцінки втомної міцності зубів зубчастих коліс при згині. Показано, що в усіх стандартах для оцінки втомної міцності зубів коліс застосовують значення границь витривалості, одержаних трудомісткими експериментальними методами. На основі аналізу відповідних даних обґрунтована необхідність розробки розрахункових залежностей для визначення границь витривалості зубів зубчастих коліс, побудованих на статистичних закономірностях подібності втомного руйнування. Запропоновано метод для розрахункової оцінки границь витривалості поверхнево зміцнених зубів коліс при згині. Проведено експериментальні дослідження границь витривалості цементованих зубів зубчастих коліс при згині. Наведено аналіз розрахункових та експериментальних даних. Показана доцільність застосування на практиці розробленого метода для розрахункової оцінки границь витривалості зміцнених зубів зубчастих коліс.
Мониторинг технического состояния судовых малооборотных дизелей
Authors: Kuznetsov V.A. 
Published: May 2020

В процессе работы были определены требования, предъявляемые к деталям ЦПГ малооборотных дизелей. Особо важную роль в длительной и надежной эксплуатации дизелей играет мониторинг и диагностирование узлов и механизмов для качественной оценки их технического состояния. Мониторинг является частью технического обслуживания любых энергетических установок независимо от типа судна, а также различных устройств и систем в целом. Цель ее заключается в получении своевременной информации о техническом состоянии отдельных деталей, узлов, механизмов двигателя в целом на основе проведения измерений и анализа результатов измерений различных параметров. Как бы долго малооборотные двигатели не эксплуатировались со временем их приходиться ремонтировать, поэтому компаниями занимающимися изготовлениями судовых дизелей предоставляться технические средства и необходимый качественно-подготовленный персонал способный диагностировать поломанный узел механизма, произвести его дефектацию, определить объём, сроки выполнения и стоимость ремонта. Надежность работы двигателя необходимо поддерживать постоянно на всех этих этапах т.к. от качества выполненных по ремонту работ зависит безопасность мореплавания судна, что в свою очередь контролируется международной морской организацией (ИМО)
HUBUNGANKARAKTER KEPEMIMPINAN DENGAN KINERJA PENGUSAHA KECIL MAKANAN OLAHAN
Authors: Ekasari Luh Dina 
Published: May 2020

Cara seseorang memimpin tentu berbeda dengan orang lain. Cara seseorang mempengaruhi orang lain, bawahan atau kelompok, kemampuan mengarahkan tingkahlaku bawahan atau kelompok itulah yang disebut dengan karakteristik seorang pimpinan. Pimpinan harus memiliki kemampuan atau keahlian khusus dalam bidang yang diinginkan oleh kelompoknya untuk mencapai tujuan organisasi atau kelompok. Tujuannya untuk mengetahui adanya pengaruh gaya yang terdiri atas kepemimpinan Kharismatik, gaya kepemimpinan Demokratis, gaya kepemimpinan Otoriter, dan gaya kepemimpinan Moralis terhadap kinerja pengusaha kecil makanan olahan di Kelurahan Tlogomas, Kecamatan Lowokwaru, Kabupaten Malang.
Dalam penelitian ini peneliti menggunakan jenis penelitian kuantitatif, Lokasi penelitian dilakukan di Kelurahan Tlogomas, Kecamatan Lowokwaru Kota Malang. Berdasarkan objek penelitian yang penulis ambil jumlah sampel yang digunakan adalah 42 pengusaha. Dengan metode Wawancara, observasi dan kuesioner dan dilakukan uji validitas dan reliabilitas untuk analisis data menggunakan analisis linear berganda (uji simultan dan uji parsial).
Bahwa penelitian ini menyimpulkan gaya kepemimpinan kharismatik, kepemimpinan otoriter dan gaya kepemimpinan demokratis tidak berpengaruh terhadap kinerja pengusaha kecil makanan olahan. kepemimpinan moralis memiliki pengaruh yang signifikan terhadap kinerja pengusaha kecil makanan olahan.
Development and implementation of special seminar “Innovative pedagogical technologies”
Authors: Makarenko Juliya V. , Osadchaya Irina V. , Anisimova Lyudmila S. , Vaganova Olga I. , Rudenko Irina V. 
Published: May 2020

Taking into account modern requirements to teacher’s personality in primary education, his knowledge of innovative pedagogical technologies’ essence as well as knowledge of methodology, relevance of the search for ways to improve the content and forms of future primary school teachers’ training has been revealed. One of the solutions to this problem can be introduction of a special seminar aimed at improving the level of innovative and technological competence of future teachers in primary education into the system of vocational training. The purpose of this article is to substantiate the conceptual and methodological significance of a special seminar "Innovative pedagogical technologies" as well as to describe process of diagnosing effectiveness of the developed special seminar. The aim of the research is achieved through the application of such theoretical and empirical methods of scientific knowledge as method of pedagogical diagnostics, methodical system modeling, method of pedagogical forecasting, analysis of results, synthesis of the results of experimental research. Based on the use of these methods, the main theoretical aspects of a special seminar development are presented, the components of its content and structure are reflected and the stages of testing effectiveness of the developed special seminar are described. The scientific novelty of the research is justified by the development of the conceptual foundations and content of the special seminar "Innovative pedagogical technologies", intended for use in the training of future primary school teachers, indicating methodological aspects of its implementation, as well as the development of a diagnostic system to test its effectiveness in the educational process of the University.
La resistencia antiperonista: clandestinidad y violencia. Los comandos civiles revolucionarios en Argentina, 1954-1955
Authors: Bartolucci Mónica 
Published: May 2020

Este trabajo intenta abordar la conformación de la identidad política antiperonista y revisar la acción clandestina de civiles que decidieron tomar las armas en contra de Perón. El foco se pondrá en el momento de mayor activismo golpista desde noviembre de 1954 hasta septiembre de 1955 y sobre todo en las estrategias de acción llevadas a cabo por uno de estos grupos, el de los nacionalistas católicos, de manera más evidente en la ciudad de Buenos Aires y Córdoba. El trabajo apunta a revisar la formación de los Comandos Civiles Revolucionarios (CCR), sus prácticas y enlaces militares, los modos de organización celular y la introducción de armas de fuego para para promover la caída del segundo gobierno peronista en septiembre de 1955. Estas prácticas marcadas por la clandestinidad serán abordadas a partir de memorias biográficas y documentos que ellos mismos dejaron. La idea es repensar uno de los muchos proyectos que vía la violencia política se enarbolaron en nombre de “la patria”, en un contexto histórico revulsivo y de inestabilidad política en la Argentina que corrió entre el exilio y la vuelta de Perón al país.