bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacteria drug resistance profile affects knee and hip periprosthetic joint infection outcome with debridement, antibiotics and implant retention
Authors: Rudelli Bruno Alves , Giglio Pedro Nogueira , Carvalho Vladimir Cordeiro , Pecora Jose Ricardo , Gurgel Henrique Melo Campos , Gobbi Riccardo Gomes , Vicente Jose Ricardo Negreiros , Lima Ana Lucia Lei Munhoz , Helito Camilo Partezani 
Published: January 2020

Abstract
BACKGROUND: evaluate the effect of bacteria drug resistance profile on the success rates of debridement, antibiotics and implant retention. METHODS: All early acute periprosthetic infections in hip and knee arthroplasties treated with DAIR at our institution over the period from 2011 to 2015 were retrospectively analyzed. The success rate was evaluated according to the type of organism identified in culture: multidrug-sensitive (MSB), methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Gram-negative bacteria (MRB) and according to other risk factors for treatment failure. The data were analyzed using univariate and multivariate statistics. RESULTS: Fifty-seven patients were analyzed; there were 37 in the multidrug-sensitive bacteria (MSB) group, 11 in the methicillin-resistant Staphylococcus aureus (MRSA) group and 9 in the other multidrug-resistant Gram-negative bacteria (MRB) group. There was a statistically significant difference (p<0.05) in the treatment failure rate among the three groups: 8.3% for the MSB group, 18.2% for the MRSA group and 55.6% for the MRB group (p=0.005). Among the other risk factors for treatment failure, the presence of inflammatory arthritis presented a failure rate of 45.1 (p<0.05). CONCLUSION: DAIR showed a good success rate in cases of early acute infection by multidrug-sensitive bacteria. In the presence of infection by multidrug-resistant bacteria or association with rheumatic diseases the treatment failure rate was higher and other surgical options should be considered in this specific population. The MRSA group showed intermediate results between MSB and MRB and should be carefully evaluated.
Sex difference in the association between education and schizophrenia in Chinese adults
Authors: Luo Yanan , Pang Lihua , Zhao Yihao , Guo Chao , Zhang Lei , Zheng Xiaoying 
Published: January 2020

Abstract
Objective: Improving education level was evidenced to decrease the risk of schizophrenia, but whether this strength of education role depends on gender is not. This study aimed to investigate whether there is sex difference in the association between education and schizophrenia in Chinese adults. Methods: Data was obtained from the Second China National Sample Survey on Disability in 2006, and restricted our analysis to 1,909,205 participants aged 18 years or older, which covered 31 provinces (administrative districts) in China. Schizophrenia was ascertained according to the International Statistical Classification of Diseases, Tenth Revision. Logistics regression models was fitted to examine the combined effect of sex and education on schizophrenia. Results: The prevalence of schizophrenia in female groups was higher than in male groups, with 0.44% (95% CI : 0.42%, 0.45%) and 0.36% (95% CI : 0.35%, 0.37%), respectively. There is a statistical significant difference that more females experienced severe or extreme difficulty in understanding and communicating. However, more males suffered from severe or extreme difficulty in the function of daily activities and participation in society. The combined effect of education and schizophrenia was statistically significant ( OR =1.05, 95%CI =1.02, 1.08), indicating that, as the level of education level increased, schizophrenia risk of females decreased faster than the risk of males. Conclusions: This study showed that additional years of education reduce the risk of schizophrenia for both men and women while also closing the gender gap between them. As education elevated, the risk of schizophrenia decreased more for women than for men. The findings indicated that improving education level may have an effect on reducing gender gaps in schizophrenia in China. Action to prevent schizophrenia and close its gender gap will require attention to the improving educational opportunities. Keywords : Schizophrenia; education ; sex difference
Willingness-to-pay and time-trade-off as the measures of burden of psoriasis: A pooled analysis of community, hospital, and web-based samples
Authors: Xiao Yi , Li Meng , Guan Xin , Sheng Ping , Tao Juan , He Meian , Zhu Wu , Chen Xiang , Shen Minxue 
Published: January 2020

Abstract
Background The study aimed to compare willingness-to-pay (WTP) and health utility measured by time-trade-off (TTO) in psoriasis. Methods A pooled sample from a community-based cohort, a hospital, and an online registry were used. WTP was elicited for control and for cure. Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) were used as references. Data distribution, concurrent validity, and area under the receiver operating characteristic curve (AUC) were compared. Results A total of 479 patients were enrolled. WTP for control demonstrated a positive association with PASI among mild psoriasis, while TTO showed an inverse correlation to DLQI. The AUC of WTP for control (0.66) was higher than that of TTO (0.48) in discriminating PASI>10, and the AUC of TTO (0.64) was higher than that of WTP for control (0.62) in discriminating DLQI>10. Conclusion WTP for control shows superiority in detecting objective severity, while TTO may be more sensitive in measuring impaired quality of life.
A retrospective cohort investigation of seroprevalence of Marburg virus and ebolaviruses in two different ecological zones in Uganda
Authors: Nyakarahuka Luke , Schafer Ilana J. , Balinandi Stephen , Mulei Sophia , Tumusiime Alex , Kyondo Jackson , Knust Barbara , Lutwama Julius J , Rollin Pierre , Nichol Stuart , Shoemaker Trevor 
Published: January 2020

Abstract
Background Uganda has experienced seven Ebola Virus Disease (EVD) outbreaks and four Marburg Virus disease (MVD) outbreaks between 2000 and 2019. We investigated the seroprevalence and risk factors for Marburg virus and ebolaviruses infections in gold mining communities around Kitaka gold mine in Western Uganda, and compared them to non-mining communities in Central UgandaMethods A questionnaire was administered and human blood samples were collected from three exposed groups in Western Uganda (gold miners, and household members of miners, non-miners living within 50 km of Kitaka mine). Controls were community members in Central Uganda far away from any gold mining activity which we considered as low-risk groups or ‘unexposed’ to filovirus infection. ELISA technique was used to analyse samples, detecting IgG antibodies against Marburg virus and ebolaviruses (filovirus).Results Miners in western Uganda were 4.8 times more likely to be seropositive compared to the non-exposed group in central Uganda (RR=4.8, 95%CI 1.3-17.9). Overall, filovirus seropositivity was 2.6% (19/724) of which 2.5% (18/724) was to Sudan virus, 0.1% (1/724) was to Bundibugyo virus, and 0.1% (1/724) to Marburg virus. One individual had IgG antibodies reactive to both Sudan virus and Bundibugyo virus. The risk factors for seropositivity to Sudan virus identified included mining (aOR=3.4, 1.3-8.5), male sex (3.1, 1.01 - 9.5), going inside mines (3.1, 1.2 - 8.2), cleaning corpses (3.1, 1.04 - 9.1) and contact with suspect filovirus cases (3.9, 1.04 -14.5).Conclusions These findings indicate that filovirus outbreaks may go undetected in Uganda and people involved in artisan gold mining or living close to mines and/or caves are more likely to be exposed to infection with either Marburg virus or ebolaviruses, likely due to increased risk of exposure to bats. This calls for active surveillance in known high-risk areas for early detection and response to prevent filovirus epidemics.
Investigation on antibody level of umbilical cord blood measles in 2017 in ankang city, Shaanxi province, China
Authors: Wan Chunge 
Published: January 2020

Abstract
Background Through the examination and analysis of the level of the antibody against the umbilical cord blood measles in maternal newborn in ankang city, to explore prevention and control measures and strategies of measles. Methods Using indirect enzyme-linked immunoadsorption testto test the level of Measles IgG antibody in 848 randomly collected neonatal umbilical cord blood samples,and Using descriptive epidemiological methods,Enter relevant data into Microsoft Excel to establish a database,Statistical analysis using SPSS. Results The positive rate of measles IgG antibody was 84.43 % in 848 neonatal umbilical cord blood samples in Ankang City.There is no statistical difference in the positive rate of neonatal umbilical cord blood measles IgG antibody in different age groups（P>0.05）,However, the positive rate of neonatal umbilical cord blood measles IgG showed a decreasing trend with the increase of maternal age;Maternal and newborn umbilical cord blood measles IgG antibody positive rate and different forms of residence, different maternal births has nothing to do with,but it is related to the county and district where it is located and the vaccination service model.In the counties where the quality of vaccination services is good, and in the areas where the township vaccination service model is implemented, the positive rate of maternal newborn umbilical cord blood measles IgG antibodies is higher, and the difference is statistically significant(P & lt; 0.05). Conclusions Vaccination of measles ingredients before pregnancy in women of childbearing age can not only increase the level of measles antibodies in people of childbearing age, but also increase the level of measles antibodies in infants born in August before the birth of Mazhenyimiao, thus effectively reducing the incidence of measles in children over 15 years of age and within the age of 8 months.It is of great significance to strengthen the standardized administration of vaccination, adjust the vaccination service model, and vigorously promote the centralized vaccination service model in townships and towns to reduce the incidence of measles.
Acute Mechanical Stress in Primary RPE Cells Induces Angiogenic Factor Expression and in vitro Angiogenesis
Authors: Vargis Elizabeth , Farjood Farhad , Ahmadpour Amir , Ostvar Sassan 
Published: January 2020

Abstract
Background Choroidal neovascularization (CNV) is a major cause of blindness in patients with age-related macular degeneration. CNV is characterized by new blood vessel growth and subretinal fluid accumulation, which results in mechanical pressure on retinal pigment epithelial (RPE) cells. Overexpressing RPE-derived angiogenic factors plays an important role in inducing CNV. Results The goal of this study was to determine whether low levels of acute mechanical stress during early CNV can induce the expression of angiogenic factors in RPE cells and accelerate angiogenesis. Using a novel device, acute mechanical stress was applied to primary porcine RPE cells and the resulting changes in the expression of major angiogenic factors were examined using immunocytochemistry, qRT-PCR, and ELISA. An in vitro tube formation assay was used to determine the effect of mechanical stress on RPE cells on angiogenesis. Our results showed an increase in the expression of major angiogenic factors in response to mechanical stress, resulting in increased in vitro angiogenesis. Abnormal epithelial-mesenchymal transition (EMT) in RPE cells is also associated with CNV and further retinal degeneration. Our qRT-PCR results verified an increase in the expression of EMT genes in RPE cells. Conclusions In conclusion, we showed that acute mechanical stress induces the expression of major angiogenic and EMT factors and promotes in vitro angiogenesis, suggesting that mechanical stress plays a role in promoting aberrant angiogenesis in AMD.
Understanding vocational students' motivation for dietary and physical activity behaviours
Authors: Kuipers Annabelle , Kloek Gitte Caroline , Vries Sanne Irene de 
Published: January 2020

Abstract
Background: Unhealthy eating behaviours and low levels of physical activity are a major problem in adolescents and young adults in vocational education. In order to develop effective intervention programmes, more research is needed to understand how different types of motivation contribute to health behaviours. In the present study the Self-Determination Theory (SDT) is used as a framework to examine how motivation contributes to dietary and physical activity behaviours in Vocational Education & Training (VET) students.Methods: This cross-sectional study included 809 students (mean age 17.8 ± 1.9 years) attending VET in the Netherlands. The Treatment Self-Regulation Questionnaire (TSRQ) for diet and physical activity, the Short QUestionnaire to ASsess Health- enhancing physical activity (SQUASH) and the Dutch Public Health Monitor questionnaire were used to asses type of motivation, physical activity and dietary behaviour. Linear multilevel regression analyses were used to investigate the association between type of motivation and dietary and physical activity behaviours. Results: Amotivation was negatively associated with breakfast frequency and was positively associated with diet soda consumption and the number of unhealthy products consumed per week. A positive association was found between autonomous motivation and water intake, breakfast frequency, fruit intake and moderate-to-vigorous physical activity. Autonomous motivation was negatively associated with the consumption of unhealthy products. Controlled motivation was not associated with physical activity or dietary behaviours.Conclusion: Type of motivation according to SDT seems to partly explain dietary and physical activity behaviours in VET students. Autonomous motivation in particular was shown to be associated with healthy behaviours and could therefore be a valuable intervention target.
Differential Regulation and Correlation between Galectin-9 and anti-CCP antibody (ACPA) in Rheumatoid Arthritis Patients
Authors: Fujita Yuya , Asano Tomoyuki , Matsuoka Naoki , Temmoku Jumpei , Sato Shuzo , Matsumoto Haruki , Furuya Makiko Yashiro , Suzuki Eiji , Watanabe Hiroshi , Kawakami Atsushi , Migita Kiyoshi 
Published: January 2020

Abstract
Background: Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim of the present study is to characterize circulating Gal-9 in patients with rheumatoid arthritis (RA) and its relationship with RA disease activity and phenotype.Methods: A total 116 RA patients and age-matched healthy controls (n=31) were included in this study. Disease activity of RA patients were determined by Disease Activity Score of 28 joint scoring system (DAS28-ESR). Levels of Galectin-9 in serum were determined by enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of Gal-9 were significantly higher in patients with RA compared to those in controls (median 7577 pg/ml; [interquartile range (IQR); 5570–10201] versus 4738 g/ml [IQR; 4267–5630], p=0.001). Higher levels of serum Gal-9 were observed predominantly in RA patients with RA-ILD (9606 pg/ml [IQR: 8522–12167] versus 7078 pg/ml [IQR: 5225–9447], p<0.001) or advanced joint damage (Stage Ⅱ-Ⅳ) (9606 pg/ml [IQR: 8522–12167] versus 7078 pg/ml [IQR: 5225–9447], p<0.001)　compared to other patients. Although serum levels of galectin-9 correlated with the titers of ACPA (r=0.275, p=0.002), levels of ACPA titers conferred the different relationship, between serum Gal-9 and inflammatory mediators or RA disease activity. Although Gal-9 was correlated with ACPA titers (r=0.508, p=0.002), there was no correlation between Gal-9 levels and erythrocyte sedimentation rate (ESR), matrix metalloproteinase-3 (MMP-3) or DAS28-ESR in RA patients with high titers of ACPA (>200u/ml). Conversely, Gal-9 was correlated with MMP-3 (r=0.300, p=0.007) or DAS28-ESR (r=0.331, p=0.004) not with ACPA titer in RA patients with low titers of ACPA titers (<200U/ml). Conclusions: Serum levels of glectin-9 were increased in RA patients and associated with RA disease activity in RA patients without high titers of ACPA. The levels of ACPA titers may influence the values of circulating galectin-9 in RA patients with various clinical phenotype. These data suggest that Gal-9 possessed the properties proinflammatory or arthropathic biomarker under the status of ACPA seropositivity,
Prevalence of Risk Factors of Non-Communicable Diseases in Oman: STEPS Survey 2017
Authors: Al-Mawali Adhra , Jayapal Sathish Kumar , Morsi Magdi , Al-Shekaili Waleed , Pinto Avinash Daniel , Al-Kharusi Hilal , Al-Harrasi Ayaman , Al-Balushi Zainab , Idikula John 
Published: January 2020

Abstract
Background Non-Communicable Diseases (NCD) represent a major public health issue and currently are the cause of 71% of deaths globally and 72% deaths in Oman. Hence, there is a need for comprehensive, up-to-date and internationally comparable data on NCD risk factors in order to evaluate the effectiveness of ongoing public health policies and to develop further NCD prevention and control interventions. The aim of the study was to provide evidence-based, up-to-date, extensive, and reliable baseline data on the behavioural and biological risk factors of NCDs in the Sultanate of Oman. Methods A cross‐sectional community‐based survey designed to be nationally representative of the Sultanate of Oman was conducted based on the WHO STEPwise approach to Surveillance (STEPS). Multi-stage stratified random sampling according to geographical distribution selected a total of 9053 households (Omani nationals and non-Omani residents). Cluster sampling was used and symmetric equal number of blocks were chosen in each governorate with 823 households chosen from each governorate and one eligible adult selected from each household randomly. The survey used demographic and behavioural information questionnaires along with physical and biochemical measurements among adults aged 18 years and above. Results The prevalence of behavioural risk factors such as tobacco use was 9%, alcohol consumption was 2%, insufficient fruit or vegetable intake was 61%, and insufficient physical activity was 39%. The prevalence of biological risk factors such as overweight and obesity was 66%, raised blood pressure was 33%, raised blood glucose was 16%, and raised blood cholesterol was 36%. The prevalence of multiple risk factors was also determined and 95% of the population were found to have more than one risk factor. Three or more risk factors were found among 33% of population aged 18-69 years and 45% of the population aged 45 years. Conclusions These findings are important to support the formulation and implementation of NCD-related policies and action plans that improve health status and prevent mortality due to NCDs in the Sultanate of Oman.
Genetic aberrations in chromatin factors are pervasive, mutually exclusive, associated with a high mutational burden and improved response to checkpoint immunotherapy in cancer
Authors: Markovska Martina , Rosalia Rodney , Stajkovska Aleksandra , Mehandziska Sanja , Janevska Marija , Kungulovski Ivan , Mitrev Zan , Kungulovski Goran 
Published: January 2020

Abstract
Background: In recent years, it has been shown that many of the pervasive genetic defects in cancer occur in chromatin modifiers. In order to obtain insights in regards to their biology and clinical relevance in cancer, we analyzed the distribution and mutual relationships of genetic aberrations in relevant chromatin modifiers in tens of thousands of publicly available cancer datasets. Results: We observed that in general, they are mutually exclusive, and their prevalence is higher in some types of cancers compared to others. Moreover, we observed a strong association between aberrations in selected chromatin modifiers and tumor mutational burden, leading to an improved response to checkpoint immunotherapy. Conclusion: All in all, this study uncovered interesting relationships between chromatin factors and features of cancer in regards to cancer biology, and cancer therapy. These insights could set the stage for follow up functional and clinical studies.
Incisional Negative Pressure Wound Therapy Dressing in Total Joint Arthroplasty: what is the evidence? A Meta-Analysis
Authors: Wei Wen-Xing , Zeng Yi , Liu Yuan , Li Ming-Yang , Wu Yuan-gang , Shen Bin 
Published: January 2020

Abstract
Background The purpose of this study is to evaluate whether incisional negative pressure therapy dressing (iNPWT) has an advantage over conventional wound dressing (CWD) on wound healing for patients with total joint arthroplasty (TJA)MethodsWe searched the electronic databases including PubMed, The Cochrane Library, EMBASE via Ovid SP, Medline via Ovid SP, to screening published randomized controlled trials and high-quality cohort studies reported that incisional negative pressure therapy dressing applied in hip and knee arthroplasty. We analyzed the overall complications, major and minor complications, dressing changes, infection rate, and the rate of reoperation. The relevant data was analyzed by RevMan5.3.Results Six studies met our criteria, and included 1405 incisions in 971 participants with total joint arthroplasty which were randomized either to incisional negative pressure therapy dressing group (n=578) or to conventional wound dressing group (n=827) .The risk for developing a minor complication between two groups was not significantly different (risk ratio [RR] 0.58, p =0.40) and for major complication was also not significantly different (RR 0.71, p =0.39). In terms of dressing changes, the iNPWT was fewer than the control group ( P <0.05). The effect of rate of infection and reoperation was not significantly different (RR 0.65, p =0.27).Conclusions For patients underwent TJA, applying iNPWT may be associated with fewer dressing change, which maybe mean less exudation. There was no significant difference on the rate of infection and reoperation, and experiencing either minor or major complications between participants in whom iNPWT versus CWD were used for wound. However, more high-quality randomized or non-randomized controlled trials with larger sample sizes and cost-effectiveness analysis are required.
New insights about myofibrillar myopathies: the role of metalloproteinases 2 and 9 in the pathogenesis
Authors: Carvalho Alzira Alves de Siqueira , Silva Vinicius Gomes , Corazzini Roseli , Silva Alan Patricio , Lacene Emmanuelle 
Published: January 2020

Abstract
Background There are few reports suggesting that gene expression and activation of various matrix metalloproteinases (MMPs) are deregulated. MMP-2 and MMP-9 represent the two MMPs, which degrade type IV collagen, the component of basement membrane.Methods We analyzed the involvement of gelatinases, MMP-2 and MMP-9, in the pathogenesis of myofibrillar myopathy (MFM). Muscle specimens from 23 patients well diagnosed with MFM, were immunostained by MMP-2 and MMP-9. We analyzed qualitatively the immunoexpression in three compartments: subsarcolemmal (SSC), intracytoplasmic (ICC) and perinuclear (PNC).Results 95,7% and 100% samples showed MMP-2 and MMP-9 upregulation ICC, respectively. PNC showed MMP-2 (82,6%) and MMP-9 (8,7%) regulation (p<0.001). SSC and ICC did not present statistical significance. There was no correlation between mutated gene and immunohistochemical pattern distribution.Conclusion Our results suggest that MMP-2 and/or MMP-9 could participate in the pathomechanism of MFM, causing damage of sarcomere and deposition of protein aggregates.