bluuebunny/crossref_metadata_2025_split huggingface dataset:
2D single crystal Bragg-dip mapping by time-of-flight energy-resolved neutron imaging on IMAT@ISIS
Authors: Strickland Joel , Tassenberg Karl , Sheppard Gareth , Nenchev Bogdan , Perry Sam , Li Jun , Dong Hongbiao , Burca Genoveva , Kelleher Joe , Irwin Steve 
Published: November 2020

AbstractThe cold neutron imaging and diffraction instrument IMAT, at the second target station of the pulsed neutron and muon source ISIS, is used to investigate bulk mosaicity within as-cast single crystal CMSX-4 and CMSX-10 Ni-base superalloys. Within this study, neutron transmission spectrum is recorded by each pixel within the microchannel plate image detector. The movement of the lowest transmission wavelength within a specified Bragg-dip for each pixel is tracked. The resultant Bragg-dip shifting has enabled crystallographic orientation mapping of bulk single crystal specimens with good spatial resolution. The total acquisition time required to collect sufficient statistics for each test is ~ 3 h. In this work, the influence of a change in bulk solidification conditions on the variation in single crystal mosaicity was investigated. Misorientation of the (001) crystallographic plane has been visualised and a new spiral twisting solidification phenomena observed. This proof of concept work establishes time-of-flight energy-resolved neutron imaging as a fundamental characterisation tool for understanding and visualising mosaicity within metallic single crystals and provides the foundation for post-mortem deduction of the shape of the solid/liquid isotherm.
Spin-coated $$\hbox {Cu}_2\hbox {ZnSnS}_{4}$$ solar cells: A study on the transformation from ink to film
Authors: Engberg Sara , Martinho Filipe , Gansukh Mungunshagai , Protti Alexander , Küngas Rainer , Stamate Eugen , Hansen Ole , Canulescu Stela , Schou Jørgen 
Published: November 2020

AbstractIn this paper, we study the DMSO/thiourea/chloride salt system for synthesis of pure-sulfide$$\hbox {Cu}_2\hbox {ZnSnS}_{4}$$Cu2ZnSnS4(CZTS) thin-film solar cells under ambient conditions. We map out the ink constituents and determine the effect of mixing time and filtering. The thermal behavior of the ink is analyzed, and we find that more than 90% of the solvent has evaporated at$$250\,^{\circ }\hbox {C}$$250∘C. However, chloride and sulfoxide species are released continually until$$500\,^{\circ }\hbox {C}$$500∘C, suggesting the advantage of a higher pre-annealing temperature, which is also commonly observed in the spin-coating routines in literature. Another advantage of a higher pre-annealing temperature is that the worm-like pattern in the spin-coated film can be avoided. We hypothesize that this pattern forms as a result of hydrodynamics within the film as it dries, and it causes micro-inhomogeneities in film morphology. Devices were completed in order to finally evaluate the effect of varying thermal exposure during pre-annealing. Contrary to the previous observations, a lower pre-annealing temperature of$$250\,^{\circ }\hbox {C}$$250∘Cresults in the best device efficiency of 4.65%, which to the best of our knowledge is the highest efficiency obtained for a pure-sulfide kesterite made with DMSO. Lower thermal exposure during pre-annealing results in larger grains and a thicker$$\hbox {MoS}_2$$MoS2layer at the CZTS/Mo interface. Devices completed at higher pre-annealing temperatures display the existence of either a Cu-S secondary phase or an incomplete sulfurization with smaller grains and a fine-grain layer at the back interface.
Pathological findings in the endometrium after microwave endometrial ablation
Authors: Nakayama Kentaro , Razia Sultana , Ishibashi Tomoka , Ishikawa Masako , Yamashita Hitomi , Nakamura Kohei , Sawada Kiyoka , Yoshimura Yuki , Tatsumi Nagisa , Kurose Sonomi , Minamoto Toshiko , Iida Kouji , Ishikawa Noriyoshi , Kyo Satoru 
Published: November 2020

AbstractThe acceptance of MEA in Japan is well demand due to its outstanding effectiveness and safety. Infrequently, a repeat MEA or hysterectomy is needed for recurrent menorrhagia in case of failure ablation. The reasons of recurrent menorrhagia subsequent MEA treatment are unclear. The objective of current study is to identify the possible causes of menorrhagia repetition following MEA, together with the observation of histological changes in the endometrium due to this treatment compared with normal cycling endometrial tissue. A total of 170 patients, 8 (4.7%) of them carried out hysterectomy after 16.8 months (range, 2–29 months) of MEA treatment. Normal (n = 47) and MEA (n = 8) treated paraffin embedded endometrial tissue were prepared for hematoxylin and eosin (H&E) and immunostaining study to recognize the histological changes in the endometrium as a result of MEA treatment. The histological features observed increased tubal metaplasia (TM) including negative expression of the estrogen receptor (ER) and progesterone receptor (PR) in the endometrium subsequent MEA treatment. Increased TM together with the absence of ER and PR expression might be a reasonable explanation for repetition menorrhagia in cases of failure ablation. Further study is required to clarify the molecular mechanisms of tubal metaplasia and the expression loss of hormone receptor in the endometrium as a result of MEA treatment. Current studies propose that low dose estrogen-progestin may not be effective with recurrent menorrhagia patient’s due to the inadequacy of hormone receptor expression in the endometrium following MEA.
Effects of dietary n-3-PUFA supplementation, post-insemination plane of nutrition and pregnancy status on the endometrial transcriptome of beef heifers
Authors: Surlis Carla , Cormican Paul , Waters Sinead M. , Lonergan Patrick , Keogh Kate , Doyle David N. , Kenny David A. 
Published: November 2020

AbstractSupplementation of cattle diets with n-3-polyunsaturated fatty acids (PUFA) can improve reproductive efficiency. Conversely, short-term fluctuations in feed supply can impact pregnancy establishment. The objectives of this study were to examine the effects of (1) dietary supplementation with n-3-PUFA and (2) post-insemination plane of nutrition on the endometrial transcriptome. Beef crossbred heifers were offered concentrate based diets fortified with n-3-PUFA (PUFA; n = 32) or not (CONT; n = 28) for 30 days prior to breeding at a synchronised oestrous. Following artificial insemination, heifers were allocated within treatment to either a high or low plane of nutrition. Heifers were maintained on these diets for 16 days following which endometrial tissue was harvested at slaughter for subsequent RNAseq analysis. The influence of pregnancy status on the endomentrial transcriptome, within each dietary treatment group, was also examined. Post-insemination diet affected (P < 0.05) the endometrial transcriptome. Specifically, within n-3-PUFA-supplemented heifers, genes involved in embryonic development and mTOR signalling pathways, important in pregnancy establishment, were identified as differentially expressed. Results indicate that dietary supplementation of cattle diets with n-3-PUFA may have a positive effect on the expression of key fertility-related genes and pathways, during the critical window of maternal recognition of pregnancy, particularly where animals are underfed.
Steering complex networks toward desired dynamics
Authors: Gutiérrez Ricardo , Materassi Massimo , Focardi Stefano , Boccaletti Stefano 
Published: November 2020

AbstractWe consider networks of dynamical units that evolve in time according to different laws, and are coupled to each other in highly irregular ways. Studying how to steer the dynamics of such systems towards a desired evolution is of great practical interest in many areas of science, as well as providing insight into the interplay between network structure and dynamical behavior. We propose a pinning protocol for imposing specific dynamic evolutions compatible with the equations of motion on a networked system. The method does not impose any restrictions on the local dynamics, which may vary from node to node, nor on the interactions between nodes, which may adopt in principle any nonlinear mathematical form and be represented by weighted, directed or undirected links. We first explore our method on small synthetic networks of chaotic oscillators, which allows us to unveil a correlation between the ordered sequence of pinned nodes and their topological influence in the network. We then consider a 12-species trophic web network, which is a model of a mammalian food web. By pinning a relatively small number of species, one can make the system abandon its spontaneous evolution from its (typically uncontrolled) initial state towards a target dynamics, or periodically control it so as to make the populations evolve within stipulated bounds. The relevance of these findings for environment management and conservation is discussed.
Relationship between tendon structure, stiffness, gait patterns and patient reported outcomes during the early stages of recovery after an Achilles tendon rupture
Authors: Laurent Didier , Walsh Lorcan , Muaremi Amir , Beckmann Nicolau , Weber Eckhard , Chaperon Frederique , Haber Harry , Goldhahn Joerg , Klauser Andrea Sabine , Blauth Michael , Schieker Matthias 
Published: November 2020

AbstractAfter an Achilles tendon (AT) injury, the decision to return to full weightbearing for the practice of sports or strenuous activities is based on clinical features only. In this study, tendon stiffness and foot plantar pressure, as objective quantitative measures that could potentially inform clinical decision making, were repeatedly measured in 15 patients until 3 months after the AT rupture by using shear wave elastography (SWE) and wearable insoles, respectively. Meanwhile, patient reported outcomes assessing the impact on physical activity were evaluated using the Achilles Tendon Total Rupture Score (ATRS). At week-2 post-injury, stiffness of the injured tendon varied from 6.00 ± 1.62 m/s (mean ± SD) close to the rupture to 8.91 ± 2.29 m/s when measured more distally. While near complete recovery was observed in distal and middle regions at week-8, the shear wave velocity in the proximal region recovered to only 65% of the contralateral value at week-12. In a parallel pre-clinical study, the tendon stiffness measured in vivo by SWE in a rat model was found to be strongly correlated with ex vivo values of the Young’s modulus, which attests to the adequacy of SWE for these measures. The insole derived assessment of the plantar pressure distribution during walking showed slight sub-optimal function of the affected foot at week-12, while the ATRS score recovered to a level of 59 ± 16. Significant correlations found between tendon stiffness, insole variables and distinct ATRS activities, suggest clinical relevance of tendon stiffness and foot plantar pressure measurements. These results illustrate how an alteration of the AT structure can impact daily activities of affected patients and show how digital biomarkers can track recovery in function over time.
A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis
Authors: Saito Motoo , Nishitani Kohei , Ikeda Hanako O. , Yoshida Shigeo , Iwai Sachiko , Ji Xiang , Nakahata Akihiro , Ito Akira , Nakamura Shinichiro , Kuriyama Shinichi , Yoshitomi Hiroyuki , Murata Koichi , Aoyama Tomoki , Ito Hiromu , Kuroki Hiroshi , Kakizuka Akira , Matsuda Shuichi 
Published: November 2020

AbstractPost-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the recovery after intra-articular injuries or surgeries. Currently, no effective treatment is available. In this study, we showed that inhibition of the acute stage chondrocyte death is a promising strategy to mitigate the development of PTOA. Namely, we examined efficacies of Kyoto University Substance (KUS) 121, a valosin-containing protein modulator, for PTOA as well as its therapeutic mechanisms. In vivo, in a rat PTOA model by cyclic compressive loading, intra-articular treatments of KUS121 significantly improved the modified Mankin scores and reduced damaged-cartilage volumes, as compared to vehicle treatment. Moreover, KUS121 markedly reduced the numbers of TUNEL-, CHOP-, MMP-13-, and ADAMTS-5-positive chondrocytes in the damaged knees. In vitro, KUS121 rescued human articular chondrocytes from tunicamycin-induced cell death, in both monolayer culture and cartilage explants. It also significantly downregulated the protein or gene expression of ER stress markers, proinflammatory cytokines, and extracellular-matrix-degrading enzymes induced by tunicamycin or IL-1β. Collectively, these results demonstrated that KUS121 protected chondrocytes from cell death through the inhibition of excessive ER stress. Therefore, KUS121 would be a new, promising therapeutic agent with a protective effect on the progression of PTOA.
Non-linear association between admission temperature and neonatal mortality in a low-resource setting
Authors: Cavallin Francesco , Calgaro Serena , Brugnolaro Valentina , Wingi Olivier Manzungu , Muhelo Arlindo Rosario , Da Dalt Liviana , Pizzol Damiano , Putoto Giovanni , Trevisanuto Daniele 
Published: November 2020

AbstractBoth neonatal hypothermia and hyperthermia represent important risk factors for neonatal mortality, but information on mortality risk across a full range of neonatal temperatures is lacking in low-resource settings. We evaluated the association between neonatal mortality and a full range of admission temperatures in a low-resource setting. This retrospective observational study was conducted at Beira Central Hospital, Mozambique. The relationship between admission temperature and mortality was evaluated using multivariable analyses with temperature modeled as non-linear term. Among 2098 neonates admitted to the Special Care Unit between January–December 2017, admission temperature was available in 1344 neonates (64%) who were included in the analysis. A non-linear association between mortality rate and temperature was identified. Mortality rate decreased from 84% at 32 °C to 64% at 34.6 °C (− 8% per °C), to 41% at 36 °C (− 16% per °C), to 26% to 36.6 °C (− 25% per °C) and to 22% at 38.3 °C (− 2% per °C), then increased to 40% at 41 °C (+ 7% per °C). Mortality rate was estimated to be at minimum at admission temperature of 37.5 °C. In conclusions, the non-linear relationship highlighted different mortality risks across a full range of neonatal temperatures in a low-resource setting. Admission temperature was not recorded in one third of neonates.
Changes of protein levels in human urine reflect the dysregulation of signaling pathways of chronic kidney disease and its complications
Authors: Hao Yiming , Reyes Luis Tanon , Morris Robert , Xu Yifeng , Wang Yiqin , Cheng Feng 
Published: November 2020

AbstractThe increasing prevalence of chronic kidney disease (CKD) seriously is threatening human health and overall quality of life. The discovery of biomarkers of pathogenesis of CKD and the associated complications are very important for CDK diagnosis and treatment. In this paper, urine protein biomarkers were investigated because urine sample collection is convenient and non-invasive. We analyzed the protein concentrations in the urine of CKD patients and extracted abnormal protein signals comparing with the healthy control groups. The enriched signaling pathways that may characterize CKD pathology were identified from these proteins. We applied surface-enhanced laser desorption and ionization time of flight mass spectrometry technology to detect different protein peaks in urine samples from patients with CKD and healthy controls. We searched the proteins corresponding to protein peaks through the UniProt database and identified the signaling pathways of CKD and its complications by using the NIH DAVID database. 42 low abundance proteins and 46 high abundance proteins in the urine samples from CKD patients were found by comparing with healthy controls. Seven KEGG pathways related to CKD and its complications were identified from the regulated proteins. These pathways included chemokine signaling pathway, cytokine–cytokine receptor interaction, oxidative phosphorylation, cardiac muscle contraction, Alzheimer’s disease, Parkinson's disease, and salivary secretion. In CKD stages 2, 3, 4, and 5, five proteins showed significantly differential abundances. The differential protein signals and regulated signaling pathways will provide new insight for the pathogenesis of CKD and its complications. These altered proteins may also be used as novel biomarkers for the noninvasive and convenient diagnosis methods of CKD and its complications through urine testing in the future.
A global model of the magnetorotational instability in protoneutron stars
Authors: Reboul-Salze A. , Guilet J. , Raynaud R. , Bugli M. 
Published: November 2020

Context. Magnetars are isolated neutron stars characterized by their variable high-energy emission, which is powered by the dissipation of enormous internal magnetic fields. The measured spin-down of magnetars constrains the magnetic dipole to be in the range of 1014 − 1015 G. The magnetorotational instability (MRI) is considered to be a promising mechanism to amplify the magnetic field in fast-rotating protoneutron stars and form magnetars. This scenario is supported by many local studies that have shown that magnetic fields could be amplified by the MRI on small scales. However, the efficiency of the MRI at generating a dipole field is still unknown.
Aims. To answer this question, we study the MRI dynamo in an idealized global model of a fast rotating protoneutron star with differential rotation.
Methods. Using the pseudo-spectral code MagIC, we performed three-dimensional incompressible magnetohydrodynamics simulations in spherical geometry with explicit diffusivities where the differential rotation is forced at the outer boundary. We performed a parameter study in which we varied the initial magnetic field and investigated different magnetic boundary conditions. These simulations were compared to local shearing box simulations performed with the code Snoopy.
Results. We obtain a self-sustained turbulent MRI-driven dynamo, whose saturated state is independent of the initial magnetic field. The MRI generates a strong turbulent magnetic field of B ≥ 2 × 1015 G and a nondominant magnetic dipole, which represents systematically about 5% of the averaged magnetic field strength. Interestingly, this dipole is tilted toward the equatorial plane. By comparing these results with shearing box simulations, we find that local models can reproduce fairly well several characteristics of global MRI turbulence such as the kinetic and magnetic spectra. The turbulence is nonetheless more vigorous in the local models than in the global ones. Moreover, overly large boxes allow for elongated structures to develop without any realistic curvature constraint, which may explain why these models tend to overestimate the field amplification.
Conclusions. Overall, our results support the ability of the MRI to form magnetar-like large-scale magnetic fields. They furthermore predict the presence of a stronger small-scale magnetic field. The resulting magnetic field could be important to power outstanding stellar explosions, such as superluminous supernovae and gamma-ray bursts.
A direct and robust method to observationally constrain the halo mass function via the submillimeter magnification bias: Proof of concept
Authors: Cueli M. M. , Bonavera L. , González-Nuevo J. , Lapi A. 
Published: November 2020

Aims. The main purpose of this work is to provide a proof-of-concept method to derive tabulated observational constraints on the halo mass function (HMF) by studying the magnification bias effect on high-redshift submillimeter galaxies. Under the assumption of universality, we parametrize the HMF according to two traditional models, namely the Sheth and Tormen (ST) and Tinker fits, derive posterior distributions for their parameters, and assess their performance in explaining the measured data within the Λ cold dark matter model. We also study the potential influence of the halo occupation distribution (HOD) parameters in this analysis and discuss two aspects regarding the HMF parametrization, namely its normalization and the possibility of allowing negative values for the parameters.
Methods. We measure the cross-correlation function between a foreground sample of GAMA galaxies with spectroscopic redshifts in the range 0.2 < z < 0.8 and a background sample of H-ATLAS galaxies with photometric redshifts in the range 1.2 < z < 4.0 and carry out a Markov chain Monte Carlo algorithm in the context of Bayesian inference to check this observable against its mathematical prediction within the halo model formalism, which depends on both the HOD and HMF parameters.
Results. Under the assumption that all HMF parameters are positive, the ST fit only seems to fully explain the measurements by forcing the mean number of satellite galaxies in a halo to increase substantially from its prior mean value. The Tinker fit, on the other hand, provides a robust description of the data without relevant changes in the HOD parameters, but with some dependence on the prior range of two of its parameters. When the normalization condition for the HMF is dropped and we allow negative values of the p1 parameter in the ST fit, all the involved parameters are better determined, unlike the previous models, thus deriving the most general HMF constraints. While all the aforementioned cases are in agreement with the traditional fits within the uncertainties, the last one hints at a slightly higher number of halos at intermediate and high masses, raising the important point of the allowed parameter range.
Weak spectral features on (101995) Bennu from the OSIRIS-REx Visible and InfraRed Spectrometer
Authors: Simon A. A. , Kaplan H. H. , Cloutis E. , Hamilton V. E. , Lantz C. , Reuter D. C. , Trang D. , Fornasier S. , Clark B. E. , Lauretta D. S. 
Published: November 2020

Context. The NASA Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) mission has obtained thousands of spectra of asteroid (101955) Bennu with the OSIRIS-REx Visible and InfraRed Spectrometer.
Aims. We present a spectral search for minor absorption bands and determine compositional variations on the surface of Bennu.
Methods. Reflectance spectra with low and high spatial resolutions were analyzed for evidence of weak absorption bands. Spectra were also divided by a global average spectrum to isolate unique spectral features, and variations in the strongest band depths were mapped on a surface shape model. The global visible to near-IR spectrum of Bennu shows evidence of several weak absorption bands with depths of a few percent.
Results. Several observed bands are consistent with phyllosilicates, and their distribution correlates with the stronger 2.74-μm hydration band. A 0.55-μm band is consistent with iron oxides and is deepest in the spectrally reddest areas on Bennu. The presence of hydrated phyllosilicates and iron oxides indicates substantial aqueous alteration in Bennu’s past.
Conclusions. Bennu’s spectra are not identical to a limited set of carbonaceous chondrite spectra, possibly due to compositional properties and spatial scale differences; however, returned samples should contain a mixture of common chondrite materials.
Diagnosekriterien bei Multipler Sklerose: ein Update
Authors: Weidauer Stefan 
Published: November 2020

ZusammenfassungNeben der klinisch-neurologischen Untersuchung spielt auch die MRT in der Diagnostik und der Verlaufsbeurteilung der Multiplen Sklerose eine wesentliche Rolle. In dieser Übersicht werden die mit der 2017er-Revision der McDonald-Kriterien einhergehenden Änderungen erläutert und differenzialdiagnostische Aspekte, sog. „green flags“ und „red flags“, dargestellt.