bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of Oral Manifestation in Diabetic Patients in Yazd 2016-2017
Authors: Ghadiri-Anar Akram , Kheirollahi Khatereh , Hazar Narjes , Namiranian Nasim , jalili sadrabad Maryam , Akhondi-Meybody Mohsen , Askari Mayani Mina 
Published: August 2020

Objective: Diabetes Mellitus (DM) is one of the most common endocrine diseases with many systemic complications such as oral manifestations. The present study aimed to compare the oral manifestations frequency in diabetic patients and healthy subjects.
Materials and Methods: This cross sectional study was conducted during 2016-17 on subjects came to Yazd Diabetic Research Center. In this study, 181 type 2 diabetic patients (T2DM) and 181 healthy individuals, based on convenient sample method, were included. Two groups were compared for basic information and oral manifestations including candidiasis, oral lichen planus (OLP), periodontitis, xerostomia, delayed oral wound healing, geographic tongue, gingival hyperplasia, fissured tongue, burning mouth and finally at least one of these lesions.
Results: The frequency of candidiasis, OLP, periodontitis, delay oral wound healing, geographic tongue, xerostomia and at least one of lesions in diabetics were significantly higher than control group (P-value< 0.001). After regression analysis and adjusting for confounding factors, candidiasis, periodontitis and xerostomia in diabetics were significantly more prevalent than non-DM patients with odds ratio of 15.16 (1.80-127.57), 9.58 (4.68-19.63) and 78.639 (10.05-615.231) respectively.
Conclusion: Xerostomia, candidiasis and periodontitis were significantly more prevalent in T2DM than Non-T2DM persons. Therefore, increasing awareness on oral manifestations in this group is recommended for timely diagnosis and referring to an oral medicine.
The Effect of Short Term Aerobic Training on Serum Insulin and Insulin Resistance in Adult Obese Females
Authors: Amini Ashraf , Mirakhori Zahra , Eizadi Mojtaba 
Published: August 2020

Objective: Obesity is associated with inflammatory process and many different diseases. The objective of this study was to assess the impact of short term aerobic training on serum resistin and insulin resistance in adult obese women.
Materials and Methods: In this quasi-experimental study, thirty untrained adult obese females matched for age 35-45 years old with body mass index (BMI) 30-36 kg/m2 were divided randomly into exercise (aerobic intervention; 6 weeks, 3 days/weekly, %55-70HRmax) and control (no training) groups. Pre and post-training of fasting blood samples were collected for measure serum resistin. Insulin resistance was calculated by HOMA-IR. Data were analyzed by the independent samples T-test.
Results: Aerobic training resulted in significant decrease in BMI (32.1 (± 2.76) vs 31.6 (± 2.80) kg/m2, P-value: 0.023), body fat percentage (44.7 (± 4.55) vs 44 (± 4.33), P-value: 0.028) and fasting glucose (94 (± 8.9) vs 79 (± 5.8) mg/dl, P-value: 0.011) in exercise group. No changes were observed on insulin resistance (1.43 (± 1.11) vs 1.18 (± 0.57) HOMA-IR, P-value: 0.124) and serum resistin (2.20 (± 1.07) vs 1.58 (± 0.87) ng/ml P-value: 0.062) by training program. All variables remained unchanged in control subjects.
Conclusion: Despite improving fasting glucose, a short-term aerobic training is not associated with anti-inflammatory property for obese females. Improved glucose could be likely attributed to other changes in metabolic markers in response to exercise training and further studies are necessary to clarify possible mechanisms
The Effect of Aerobic Training on Tumor Necrosis Factor alpha, Hypoxia-Inducible Factor-1 alpha & Vascular Endothelial Growth Factor Gene Expression in Cardiac Tissue of Diabetic Rats
Authors: Bakhtiari Fariba , Matin Homaee Hasan , Ghazalian Farshad 
Published: August 2020

Objective: The goal of this research was to determine the influence of 4 weeks aerobic training on gene expression of tumor necrosis factor alpha (TNF-α), hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in the cardiac tissue of diabetic rats.
Materials and Methods: In an experimental study, 30 male wistar rats were partitioned into three groups (n=10), diabetic aerobic training, diabetic control and healthy control (n=10). Induction of type 2diabetes (T2DM) was done by intraperitoneal infusion of streptozotocin. The progressive aerobic training protocol entailed 4 weeks, 5 sessions per week running on treadmill at velocity of 20 m/min for 60 min. The gene expression of TNF-α, VEGF and HIF-1α were measured by real time & PCR. One way analysis of variance and bonferroni test were applied to analysis the data. The significant level was set at P-value< 0.05.
Results: The results indicated that the aerobic training induced significant decrease in TNF-α mRNA (P-value< 0.001) and significant increase in HIF-1α mRNA (P-value< 0.001) and VEGF mRNA (P-value< 0.001) compared to diabetic control group.
Conclusion: It appears that aerobic training with reduction of TNF-α issues an affirmative effect on angiogenesis, as a result, it improves diabetic cardiac.
Daños Punitivos Y El Artículo 164 Del Texto Refundido De La Ley General De La Seguridad Social (Prestaciones Económicas Derivadas De Accidentes De Trabajo
Authors: Granizo Javier Espín 
Published: August 2020

El presente artículo se plantea si existe presencia de los daños punitivos en el ordenamiento jurídico español, para ello, se realiza un estudio de una de las fórmulas legislativas que más debate ha suscitado con respecto a dicha forma indemnizatoria: el recargo de las prestaciones del artículo 164 TRLGSS.
Primero, se definirá el concepto de daños punitivos, aprovechando para situar los ordenamientos en los que se utiliza dicha fórmula indemnizatoria. Luego, se pormenorizarán algunas de sus más importantes características y funciones, para pasar a clasificarlos por tipos. Finalmente, se expondrán ejemplos extraídos de las legislaciones de ordenamientos de tradición escrita (civil law) con mención especial al artículo 164 TRLGSS, que hará preguntarse si la fórmula del recargo de las prestaciones es el principal precedente de los punitive damages en nuestro derecho.
Las Tres Fases De La Ausencia De Las Personas En España Desde La Ley 15/2015
Authors: Solutions Open Journal 
Published: August 2020

En virtud del grado de desconexión que existe entre la persona y el lugar de su residencia habitual nos encontramos con una situación de mera desaparición – se presume la vida-, o bien con la declaración de ausencia legal – se duda sobre la vida-, o con la declaración de fallecimiento – se presume la muerte-. Tanto la incomunicación como la incertidumbre están presentes en las tres fases de la ausencia.
En España, la Ley 15/2015, de 2 de julio, de la Jurisdicción Voluntaria, introduce importantes cambios en la regulación de esta temática que consisten, fundamentalmente, en atribuir más funciones al letrado de la administración de justicia, en detrimento del juez; entre ellas destaca realizar el nombramiento tanto del defensor judicial del desaparecido como del representante del declarado ausente; declarar no solo el fin de la situación de ausencia legal sino también el fallecimiento de la persona, indicando la fecha desde la que se entiende que acontece la muerte; y acortar considerablemente los plazos para efectuar la declaración de fallecimiento, si la desaparición ocurre en circunstancias de riesgo.
The Position Of The Supreme Court Relating To The Protection Of The Fundamental Rights Of The Corporate Criminal Liability In The Criminal Proceedings
Authors: García Fernando Santa-Cecilia , Flores Begoña Fernández 
Published: August 2020

La comunicación, tiene como idea central, comentar las Sentencias de la Sala de lo Penal del Tribunal Supremo, en relación a cómo se articula la responsabilidad penal de la persona jurídica con la de los integrantes de la entidad que hayan podido cometer el delito.
Para ello se analizan diversos derechos fundamentales que se han estudiado en dichas sentencias con el fin de comprobar si a la persona jurídica se le ampara con los mismos derechos que la persona física.
En especial, estudiaremos si en el procedimiento penal se garantiza el Derecho Fundamental de Defensa, contenido en la Constitución Española, a la persona jurídica de la misma manera que a la persona física.
The main idea behind this communication is to comment the Judgments of The Criminal Chamber of the Spanish Supreme Court, relating to how corporate criminal liability interacts with the criminal liability of the individuals within the company who may have committed a criminal offence.
Several fundamental rights that have been studied in these sentences are analyzed in order to verify whether the corporate liability is protected by the same rights as the natural person.
In particular, we will study whether the Fundamental Defense Law, contained in the Spanish Constitution, is guaranteed to the corporate liability in the criminal procedure in the same way as to the natural person.
Exploring the determinants of global life expectancy in an ecological perspective
Authors: MONDAL Md. Nazrul İslam , BAKİ Abu Naser Muhammad Abdul , HOQUE Md. Nazrul , KHAN Hafiz T.a. , KHAN Md. Nuruzzaman 
Published: August 2020

Objective: This study is designed to
understand the impacts of demographic events, socioeconomic differentials,
health factors’ availability, and environmental reasons which influence life
expectancy (LE) globally. Methods: Data
of 183 countries were taken from the United Nations agencies. The predicted
variable was LE, and the determinants were demographic events, socioeconomic
factors, health-related factors, and environmental issues. Descriptive
statistics, correlation analysis, and backward multiple regression analysis
were used to reach the research objectives. Results: The lowest LEs were found in the African countries; and LE was found significantly
associated (p&lt;0.05) with a wide
range of demographic, socioeconomic, health, and environmental factors. The necessity of full coverage of
immunization, higher income, and improved sanitation are expected to raise LE. However, LE may be increased by way of decreased fertilities, Human Immunodeficiency
Virus (HIV) prevalence, and carbon dioxide () emissions.
Conclusions: LE is influenced by
different demographic, socioeconomic, health, and environmental factors.
Country-level and global efforts should be taken to raise LE throughout the reduction of HIV infection, births, and emissions. The policy-makers should focus on
advancing reproductive decisions, increasing immunization coverage, and
upturning improved sanitation usage.
Rural-urban comparison in prevalence of hypertension and its factors among adolescents of Sarawak, Malaysia: A cross-sectional study
Authors: CHEAH Whye Lian , CHANG Ching Thon , HAZMİ Helmy , KHO Grace, Woei Feng 
Published: August 2020

Objectives: This paper reports a study of the prevalence of pre-hypertension and hypertension, and its associated factors among secondary school students in Sarawak. Methods: It was a cross-sectional study using questionnaire, anthropometric and blood pressure measurement. Results: A total of 2461 secondary school children participated. The prevalence of pre-hypertension was 13.2%, stage 1 hypertension was 12.4% and stage 2 hypertension was 4.6%. The prevalence of overweight and obesity was 24.3%, elevated waist circumference was 13.5, and overfat and obese was 6.7%. Based on the urban model, factors that were associated with pre-hypertension were age, male, parent with history of hypertension, overweight and obese. At the hypertension level, only male, overweight and obese were found to be associated. A higher odds ratio was found for elevated waist circumference of 4.42 (95% CI:1.75, 11.11) to be associated with hypertension. In rural model, factors found to be associated with pre-hypertension were age, male, ethnic group (Chinese), overweight and obese, elevated waist circumference. For pre- hypertension level, variables that were consistently to be associated with hypertension were male, ethnic group (Iban and Chinese), overweight and obese, elevated waist circumference, and parent with history of hypertension, overfat and obese. Conclusions: The prevalence of pre hypertension and hypertension was found to be different between urban and rural area, gender and obesity were found to be associated with elevated blood pressure. There is a need to emphasize earlier detection and intervention among younger generation on hypertension.
Opioid Stewardship in Orthopaedic Surgery
Authors: Haskel Jonathan D. , Yousafzai Mehek , Bloom David A. , Hutzler Lorraine , Lemos Connor , Bosco Joseph A. , Campbell Kirk A. 
Published: August 2020

» The abuse of prescription opioid pain medication has contributed to the U.S. opioid crisis.» Opioid stewardship programs ensure that our patients receive the safest and most effective opioid regimens.» Opioid stewardship programs involve a multidisciplinary team, including pharmacists, orthopaedic surgeons, nurses, pain management personnel, and anesthesiologists. All of these stakeholders work together to formulate the best evidence-based use of these medications.
Peran Wirausaha Pertanian dalam Menghadapi Era Disrupsi Inovasi
Authors: Perwita Atika Dyah , Saptana NFN 
Published: August 2020

<p>Changes in strategic environment of economic globalization including disruptive innovation require agribusiness actors’ view adjustment. This paper discusses role of agri-entrepreneurs dealing with distrubictive innovation in agriculture. There are three elements of disrupsi innovation, i.e. (i) improvement levels acceptable to customer; (ii) improvement path when new agricultural commodities are introduced and refined through technological innovations; (iii) importance of different understanding between continuous and disruption innovations. Professional managers are encouraged to grow a new business expected to compete with the established ones. Agricultural business models for the upper-middle class consumers run by young entrepreneur produce new products with premium prices but the sale volume is limited. It is important to inspire young agri- entrepreneurs who accustomed to disrupted innovation to develop business based on their goals and market segments.</p><p> </p><p>Abstrak</p><p>Perubahan lingkungan strategis berupa globalisasi ekonomi termasuk disrupsi inovasi memerlukan cara pandang baru pelaku usaha agribisnis. Tulisan ini membahas peran kewirausahaan agribisnis menghadapi era disrupsi inovasi. Ada tiga unsur disrupsi inovasi yang penting, yaitu: (i) tingkatan penyempurnaan yang dapat diterima oleh pelanggan; (2) jalur untuk penyempurnaan melalui terobosan inovasi; (iii) pemahaman yang berbeda antara inovasi berkelanjutan dan disrupsi inovasi. Para manajer profesional didorong untuk menumbuhkan bisnis baru yang dapat bersaing dengan bisnis yang telah mapan. Para wirausahawan muda menjalankan model bisnis pertanian dengan sasaran konsumen golongan ekonomi menengah-atas dengan introduksi komoditas kualitas prima dan harga premium, namun volume pasar terbatas. Implikasinya adalah perlu menyiapkan wirausaha pertanian muda yang memahami disrupsi inovasi untuk menghasilkan produk pertanian berdasarkan tujuan dan segmen pasarnya.</p>
Inovasi Pertanian dan Pemberdayaan Masyarakat Petani di Lahan Gambut
Authors: Rachmawati Rika Reviza , Tarigan Herlina 
Published: August 2020

<p>Indonesia is blessed with large potential peatland areas. Growing rice in peatland areas, for example, may be harmful to the environment if it is inappropriate farming practice. This paper aims to identify the best agricultural innovation and to propose strategic recommendation for peatland areas management. Farmers have applied agricultural innovations in growing rice in peatland areas with limited ecological damages carried out through water control management such as one way-water management, canal blocking, surjan or tukungan, and varieties adapted to peatland environment. The government has launched some measures to support peatland ecosystem but farmers’ support is inadequate. Implementing good agricultural technology through increased community participation in sustainable peatland management practices, strengthening farmers’ institution, information dissemination, and mutual community partnership.</p><p> </p><p>Abstrak</p><p>Indonesia dikaruniai lahan gambut yang tersebar luas. Pemanfaatan lahan gambut untuk kegiatan pertanian padi banyak menimbulkan kontroversi apabila tidak dibudidayakan secara tepat. Tulisan ini membahas inovasi pertanian yang tepat dan merekomendasikan strategi pemberdayaan petani di kawasan lahan gambut. Inovasi pertanian untuk menanam padi di lahan gambut tanpa merusak lingkungan di antaranya pengaturan tata air yang mampu menekan terjadinya penurunan fungsi lingkungan, seperti tata air satu arah, tabat konservasi, surjan dan tukungan, sistem drainase dangkal, hingga inovasi pemberian kapur (ameliorasi), pemupukan N dan P serta pemilihan varietas tanaman adaptif baik tanaman pangan, hortikultura, dan perkebunan. Berbagai usaha dan kebijakan yang dilakukan pemerintah untuk menjaga ekosistem lahan gambut belum optimal hasilnya karena kurang mendapat dukungan masyarakat setempat. Diperlukan pemberdayaan petani di kawasan lahan gambut agar lebih peduli kelangsungan ekosistem. Penguatan kelembagaan petani berperan dalam pemecahan masalah usaha tani, penyebarluasan informasi, penerapan teknologi sesuai agroekosistem, serta membangun kerja sama dan kemitraan yang saling menguntungkan.</p>
Interaction analysis on transmissibility of main pathogens of hand, foot, and mouth disease in Xi’an: a modelling study
Authors: Bai Yao , Liu Kun , Shao Zhongjun , Chen Zhijun 
Published: August 2020

Abstract
Objectives: Hand, foot and mouth disease (HFMD) is a new infectious disease that has attracted much attention at home and abroad, and it spreads widely. In this study, we aimed to explore the interaction between the main pathogens of HFMD through the model of transmission dynamics.Method: The database of HFMD in Xi'an City was established and the main pathogens (EV71, CoxA16, other enteroviruses) were monitored for a long time. In the study, we defined the ascending period of reported cases as Rasc, and the descending period as Rdes, and calculated the regeneration number of the two periods using susceptible–infectious–recovered model.Results: In Xi’an City, Rasc and Rdes of HFMD was 1.39 (95% CI: 1.31 – 1.48) and 0.70 (95% CI: 0.65 – 0.74), respectively. CoxA16 and other enteroviruses interacted with each other and decreased the value of Rasc. However, Rdes of CoxA16 was increased by other enteroviruses directionally. However, during the reported cases decreasing period, interactions only occurred between EV71 and other enteroviruses and between CoxA16 and other enteroviruses. These interactions all decreased Rasc but increased Rdes of affected pathogens.Conclusions: There is interaction among pathogens of HFMD in Xi'an City. The reproduction number of pathogens increased or decreased to a certain extent after interaction, and finally approached 1.
Proteomic and metabolic profile&nbsp;analysis&nbsp;of low-temperature storage responses in&nbsp;Ipomoea batata&nbsp;Lam. tuberous roots
Authors: Cui Peng , Li Yongxin , Cui Chenke , Huo Yanrong , Lu Guoquan , Yang Huqing 
Published: August 2020

Abstract
Background: Sweetpotato ( Ipomoea batatas L.) is one of the seven major food crops grown worldwide, with 70-75% of production in China. Cold stress often can cause protein expression pattern and substance contents variations for tuberous roots of sweetpotato during low-temperature storage. Recently, we developed proteometabolic profiles of the fresh sweetpotatoes (cv. Xinxiang) in an attempt to discern the cold stress-responsive mechanism of tuberous root crops during post-harvest storage. Results : For roots stored under 4℃ condition, the CI index, REC and MDA content in roots were significantly higher than them at control temperature (13 ℃). The activities of SOD, CAT, APX, O 2 .- producing rate, proline and especially soluble sugar contents were also significantly increased. Most of the differentially expressed proteins (DEPs) were implicated in pathways related to metabolic pathway (~22%), especially phenylpropanoids (~10%) and followed by starch and sucrose metabolism (~3%). Proteins including L-ascorbate peroxidase 3 and catalase were down-regulated during low temperature (4℃) storage. α-amylase, sucrose synthase and fructokinase were significantly up-regulated in starch and sucrose metabolism, while β-glucosidase, glucose-1-phosphate adenylyl-transferase and starch synthase were opposite. Furthermore, metabolome profiling revealed that glucosinolate biosynthesis, tropane, piperidine and pyridine alkaloid biosynthesis as well as protein digestion and absorption played a leading role in metabolic pathways of sweetpotato roots. More importantly, leucine, tryptophan, tyrosine, isoleucine and valine were all significantly up-regulated in glucosinolate biosynthesis. Data are available via ProteomeXchange with identifier PXD017728. Conclusions: Our proteomic and metabolic profile analysis of sweetpotato roots stored at low temperature reveal that the antioxidant enzymes activities, proline and especially soluble sugar content were significantly increased. Most of the DEPs were implicated in phenylpropanoids and followed by starch and sucrose metabolism. The discrepancy between proteomic (L-ascorbate peroxidase 3 and catalase) and biochemical (APX/CAT enzyme activity) data may be explained by higher H 2 O 2 levels and increased glutathione and ascorbate redox states, which enhanced the CAT/APX enzyme activity indirectly. Glucosinolate biosynthesis played a leading role in metabolic pathways of sweetpotao roots. More importantly, leucine, tryptophan, tyrosine, isoleucine and valine were all significantly up-regulated in glucosinolate biosynthesis.