bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrodynamic impact of sandwich structures with vibration isolation and structural damping properties
Authors: den Besten J.H. , Huijsmans R.H.M. , Vredeveldt A. 
Published: December 2024

Foam filled hull structures show, especially for high speed crafts like RIB's, new opportunities. These hull structures, sandwich structures with aluminium or fibre reinforced plastic face sheets and a flexible foam core, large compared to the face sheet thickness, have the advantage of low density, high strength, water penetration resistance, high corrosion resistance and promising vibration isolation and structural damping characteristics. Particular advantage is expected in case of dynamic loading in environmental severe conditions. Primary objective is to develop an analytical, 2D, mathematical model for the local structural response of a hydrodynamic impact loaded sandwich structure with vibration isolation and structural damping properties. The structural response is determined by solving semi-analytically a hydro-elastic coupled sandwich flexible core model and a hydrodynamic impact model in modal space, verified by results found in literature and FEM calculations. Beyond structural weight savings and increased buoyancy, an increased comfort level and less fatigue damage sensitivity compared to stiffened panel hull structures may be obtained.
Smart control of fast ships – Part 1: A setup for automated proactive control of the thrust used to increase the operability of a small planing monohull sailing in head seas
Authors: van Deyzen A.F.J. , Keuning J.A. , Huijsmans R.H.M. 
Published: December 2024

While sailing in head or bow quartering seas operators on board of small planing boats try to avoid unacceptably large vertical peak accelerations, the main limiting factor for operability, by temporary speed reductions. The operators observe the incoming wave, roughly estimate whether or not the next impact might be too severe, and if so, they choose a certain amount of thrust reduction. Results of full scale trials suggested that an increase of operability may be realised using this so-called thrust control. In this paper the concept of smart control for small planing monohulls sailing in head seas has been introduced. The idea of smart control is that a solution for the increase of the operability of small planing monohulls may be found by using automated proactive control of the thrust. The main purpose of smart control is to keep the vertical accelerations below a predefined threshold value while striving at the highest possible average forward speed during a trip. Three elements are essential for such a control system: a shipboard wave measurement system, a computational model that predicts the response and a stable control system for the thrust.
KONTRIBUSI MUHAMMAD AL-FATIH DALAM MENINGKATKAN ILMU MELALUI PENGEMBANGAN PENDIDIKAN ISLAM DI TURKI
Authors: Kumala Siti Fatmawati , Maslihah Anis , Rossidy Imron 
Published: December 2024

Tujuan dari artikel ini untuk mengetahui sejauh mana kontribusi Sultan Muhammad Al-Fatih dalam meningkatkan ilmu melalui pengembangan pendidikan Islam di Turki, ditinjau dari aspek historis. Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif adapun proses pengumpulan data dilakukan dengan metode studi kepustakaan (library research). Hasil penelitian ini menunjukkan bahwa kontribusi Sultan Muhammad Al-Fatih dalam meningkatkan ilmu melalui pengembangan pendidikan Islam di Turki dapat dilihat dari upaya pendirian akademi dan sekolah, seperti penggunaan Masjid Ayashofia dan Zeyrek sebagai pusat pendidikan Islam pertama di Konstantinopel (Istanbul,Turki). Kemudian ia mengembangkan Darul Funun yang kini menjadi cikal bakal Istanbul university. Selain itu juga Sultan Muhammad Al-Fatih membangun beberapa lembaga pendidikan diantaranya yaitu Madrasah Miftah, Madrasah Kirkha, Madrasah Ellili, Madrasah Sahn-I, Madrasah Altmish. Madrasah Hasiye-I Tecrid, Madrasah Zeyrek, Madrasah Tetimme, Madrasah Otuzlu, Madrasah Ibtidayah Haric, Madrasah Darull hadis, Madrasah Darulsyifa, Madrasah Eyup, Madrasah Mektep.
Unjuk Kerja Pembangkit Listrik Tenaga Uap
Authors: Sandi Rizky Wira , Sunanda Wahri , Puriza M. Yonggi 
Published: December 2024

Pemanfaatan limbah padat kelapa sawit PT Bumi Sawit Sukses Pratama di Provinsi Kepulauan Bangka Belitung). sebagai sumber bahan baku energi listrik menjadi salah satu pilihan diantara sumber energi baru lainnya untuk memenuhi kebutuhan energi listrik selain bersumber dari PLN. Untuk pembangkit listrik tenaga uap yang dijalankan, sistem didukung oleh turbin dengan kapasitas 2 MW dan 2 unit boiler dengan kapasitas masing-masing 45 ton/jam yang dioperasikan secara bergantian. Efisiensi boiler unit 1 terendah didapat 39% dan tertinggi 49%. Sedangkan efisiensi terendah pada boiler unit 2 yakni 39% dan tertinggi 49%. Kemudian untuk produksi uap pada boiler unit 1 tertinggi 34.300 kg/jam dan terendah 27.500 kg/jam. Lalu untuk produksi uap boiler unit 2 tertinggi 34.800 kg/jam dan terendah 27.500 kg/jam
Pengembangan usaha rumah potong unggas dalam upaya menjamin peredaran daging unggas halal dan meningkatkan kesehatan masyarakat veteriner
Authors: 'Ula Ahmad Nilnal Munachifdlil , Yasin Rozaq M. , Arrohman Sigit 
Published: December 2024

Kebutuhan akan daging unggas yang halal, sehat, memenuhi kriteria kesmavet tidak hanya untuk masyarakat muslim, tetapi juga masyarakat non-muslim. Selama ini pelaku usaha rumah potong unggas masih belum sepenuhnya mengetahui tentang kewajiban jaminan halal akan produksi dagingnya dan juga kesehatan masyarakat veteriner. Alasan yang dikemukakan yaitu karena faktor ketidaktahuan, syarat yang tidak mudah dan juga lokasi usaha yang belum memenuhi kriteria. Mitra pelaku usaha yaitu pengusaha rumah potong unggas di Pasar Bareng Kudus. Metode yang digunakan dalam pengabdian ini yaitu metode Asset Based Community Development (ABCD). Pengabdian ini meliputi beberapa tahapan 1) Sosialisasi; 2) Pelatihan; 3) Penerapan teknologi; 4) Pendampingan dan Evaluasi dan 3) Keberlanjutan program yang bertujuan untuk meningkatkan usaha mitra. Hasil pengabdian ini menunjukkan mitra memiliki pengetahuan tentang standar halal, kesmavet dan mesin bubut semi-otomatis sesuai dengan jenis unggas yang disembelih. Mitra jadi lebih mengetahui tentang cara memenuhi syarat teknis dan higiene dalam upaya menyediakan daging unggas halal di masyarakat.
Evaluation method of Driver’s olfactory preferences: a machine learning model based on multimodal physiological signals
Authors: Tang Bangbei , Zhu Mingxin , Hu Zhian , Ding Yongfeng , Chen Shengnan , Li Yan 
Published: December 2024

IntroductionAssessing the olfactory preferences of drivers can help improve the odor environment and enhance comfort during driving. However, the current evaluation methods have limited availability, including subjective evaluation, electroencephalogram, and behavioral action methods. Therefore, this study explores the potential of autonomic response signals for assessing the olfactory preferences.MethodsThis paper develops a machine learning model that classifies the olfactory preferences of drivers based on physiological signals. The dataset used for training in this study comprises 132 olfactory preference samples collected from 33 drivers in real driving environments. The dataset includes features related to heart rate variability, electrodermal activity, and respiratory signals which are baseline processed to eliminate the effects of environmental and individual differences. Six types of machine learning models (Logistic Regression, Support Vector Machine, Decision Tree, Random Forest, K-Nearest Neighbors, and Naive Bayes) are trained and evaluated on this dataset.ResultsThe results demonstrate that all models can effectively classify driver olfactory preferences, and the decision tree model achieves the highest classification accuracy (88%) and F1-score (0.87). Additionally, compared with the dataset without baseline processing, the model’s accuracy increases by 3.50%, and the F1-score increases by 6.33% on the dataset after baseline processing.ConclusionsThe combination of physiological signals and machine learning models can effectively classify drivers' olfactory preferences. Results of this study can provide a comprehensive understanding on the olfactory preferences of drivers, ultimately enhancing driving comfort.
Identification and characterization of a Relish-type NF-κB, DvRelish, in Dermacentor variabilis in response to Rickettsia rickettsii infection
Authors: Fongsaran Chanida , Verhoeve Victoria I. , Jirakanwisal Krit , Harris Emma K. , Macaluso Kevin R. 
Published: December 2024

Ixodid ticks serve as hosts and transmission vectors for several obligate intracellular bacteria, including members of the spotted fever group (SFG) of Rickettsia. Although ticks generate an immune response to bacterial insults, many of the signaling molecules associated with the response and how they may contribute to vector competence for Rickettsia are undefined. In this study, we isolated a full-length dvrelish transcript from Dermacentor variabilis, which encoded a Relish-type NF-κB. The presence of a canonical Rel homology domain (RHD) consistent with NF-κB proteins suggested a role in tick immune response for DvRelish. The expression of DvRelish was confirmed in tick tissues and fluorescent microscopy of tick hemocytes indicated increased expression following infection with Rickettsia as compared to a non-tick-borne bacterial pathogen. To further determine the effect of dvRelish gene knockdown on rickettsial infection, we used RNA interference-mediated gene knockdown in D. variabilis and demonstrated that transcription of dvRelish was decreased after 24 h post-injection of siRNA. We then assessed the response of D. variabilis when exposed to Rickettsia rickettsii and determined that transcription of dvRelish was inversely associated with rickettsial loads at 48 h post-exposure. Further studies are required to broaden the understanding of differential immune responses in ticks to SFG Rickettsia infection and elucidate the role played by the arthropod immune system in vector competence.
Gender-based violence among women and girls in conflict-affected areas of Northeast Amhara, Ethiopia
Authors: Dellie Endalkachew , Salelew Endalamaw , Mihret Fetene Samrawit , Negash Wubshet D. , Kebede Adane , Haile Tsegaye G. , Alemu Melaku Birhanu , Park Jinha , Tefera Selamawit , Alene Bruhtesfa Mouhabew , Atnafu Asmamaw 
Published: December 2024

BackgroundGender-Based Violence (GBV) is one of the major problems that women and girls encountered during the conflict between the Ethiopian federal government and the Tigray People's Liberation Front (TPLF). However, there is a gap in evidence regarding gender-based violence resulting from the ongoing conflict in these areas. Therefore, this study assessed the prevalence of GBV and its contributing factors in the conflict-affected northeastern Amhara region of Ethiopia.MethodsA community-based cross-sectional study was conducted from July 7th to September 30th, 2023, among 597 women and girls who lived in the three most conflict-affected districts (Wadla, Lay-Gaynt, and Meket) in northeastern Amhara regional state of Ethiopia. GBV was assessed using the WHO multi-country study on women's health and domestic violence against women questionnaire, which has 13 items and measures three violence domains (emotional, physical, and sexual). A binary logistic regression analysis was conducted. We used Adjusted Odds Ratios (AOR) with their respective 95% Confidence Intervals (CI) and a p-value of &lt;0.05 to identify statistically significant factors.ResultsThe overall prevalence of gender-based violence was 39.0% (95%CI: 35.2–43.6); 36.7% were experienced emotional, 15.4% physical, and 8.9% sexual violences. The burden is higher among individuals who are divorced, substance users, have low social support, or have participated in the war.ConclusionsTwo-fifths of women and girls in conflict-affected areas of the northeastern Amhara region experienced violence. Thus, collaboration between healthcare providers and policymakers is needed to enhance care for victims, including the provision of social support and substance use mitigation.
Prognostic significance of hemoglobin, albumin, lymphocyte and platelet score in solid tumors: a pooled study
Authors: Li Jinze , Zheng Jing , Wang Puze , Lv Dong 
Published: December 2024

ObjectiveThe high hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been reported to be a good prognostic indicator for several malignancies. However, more evidence is needed before it can be introduced into clinical practice. Here, we systematically evaluated the predictive value of HALP for survival outcomes in patients with solid tumors.MethodsThis study was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Assessing the Methodological Quality of Systematic Reviews (AMSTAR) Guidelines. In March 2024, an electronic literature search was performed for articles regarding the prognostic role of HALP in solid tumors. Data from studies with reported risk ratios (HRs) and 95% confidence intervals (CIs) were pooled in a meta-analysis. Study bias was assessed using the QUIPS tool.ResultsOf the 729 articles reviewed, 45 cohorts including data from 17,049 patients with cancer were included in the pooled analysis. The pooled results demonstrated that elevated HALP score was significantly associated with favorable overall survival (HR = 0.60, 95% CI 0.54-0.67, p &lt; 0.01), cancer-specific survival (HR = 0.53, 95% CI 0.44- 0.64, p &lt; 0.01), progression-free survival (HR = 0.62, 95% CI 0.54-0.72, p &lt; 0.01), recurrence-free survival (HR = 0.48, 95% CI 0.30-0.77, p &lt; 0.01), and disease-free survival (HR = 0.72, 95% CI 0.57-0.82, p &lt; 0.01). Subgroup analyses based on various confounding factors further revealed the consistent prognostic impact of HALP on overall survival in patients with solid tumors.ConclusionsOur findings suggest that high HALP is associated with better survival outcomes in patients. The HALP score is a potential prognostic biomarker in solid tumors, but it needs to be further studied whether it can improve the established prognostic model.
SARS-CoV-2 immune responses in patients with multiple myeloma and lenalidomide maintenance therapy
Authors: Martac Ioana , Beer Sina A. , Schenk Aileen , Ahmad Osama , Maier Claus-Philipp , Demirel Gülay , Preuß Beate , Klein Reinhild , Stanger Anna M. P. , Besemer Britta , Hensen Luca , Lengerke Claudia 
Published: December 2024

IntroductionMultiple myeloma (MM) is an uncontrolled plasma cell proliferation in the bone marrow, leading to immune dysregulation with impaired humoral immune responses. Conversely, cellular-based responses play a vital role in MM patients. However, the extent and duration of cellular-induced protection remain unclear to date. Here, immunomodulatory drugs (IMiDs) like Lenalidomide (Lena) become interesting, as they may have stimulatory effects on T-cell functioning.MethodsIn this study we investigated immune responses elicited by COVID-19 vaccine or infection comparing 43 healthy volunteers (avg. 35y, 72.1% female, 81.4% previously COVID-19 infected), with 41 MM patients under Lena maintenance therapy (avg. 63.8y, 51.2% female, 61% previously COVID-19 infected). Humoral responses to SARS-CoV-2 spike (S), spike-RBD, and nucleocapsid (N) were measured via ELISA in subjects’ plasma. Freshly isolated PBMCs, incubated with SARS-CoV-2 peptides (N, S), activation induced marker (AIM) assays and flow cytometry, allowed us to assess cellular responses (CD8+ T, T(F)H: CD4+ T (follicular) helper).ResultsWhereas healthy controls showed significant better humoral responses (N IgA p&lt;0.001), T cell responses were robust in the MM group (higher S-act. TH, p&lt;0.001). Stratified by COVID-19 status, the MM group showed higher N-act. TH (p=0.03). These results were unchanged comparing a Lena intake with Lena break around vaccination.DiscussionTaken together, MM patients under Lena therapy exhibit weakened antibody production but present a robust T cell response following SARS-COV-2 infection or vaccination. Our results highlight the importance of vaccination in this subgroup and moreover, argue against a Lena intake break around the time of vaccination.
The association between the body roundness index and the risk of chronic kidney disease in US adults
Authors: Zhang Jiaying , Yu Xiaofeng 
Published: December 2024

AimWe aimed to systematically assess whether the level of body roundness index (BRI) is associated with the risk of developing chronic kidney disease (CKD) in US adults.MethodsThe studied data was extracted from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. A total of 29,062 participants aged ≥20 years with complete information about BRI and CKD were included in this study. Logistic regression analysis, multivariate linear regression analysis, restricted cubic spline (RCS) plots curve, stratified analysis and receiver operating characteristic (ROC) curve were performed to investigate the association between BRI and CKD.ResultsA total of 29,062 patients were included, involving 4,623 individuals with CKD and 24,439 individuals without CKD. A higher BRI level was substantially related to an increased prevalence of CKD in US adults. After adjusting for confounding variables, the BRI in the fourth quartile was correlated to a higher CKD prevalence (OR: 1.36; 95% CI: 1.10–1.70) compared to the lowest quartile. After adjusting for confounding variables, the BRI in the fourth quartile was correlated to a higher CKD prevalence (OR: 1.36; 95% CI: 1.10–1.70) compared to the lowest quartile. However, in the subgroup analysis stratified by race and body mass index (BMI), no significant associations between BRI and CKD were observed among Mexican participants (OR: 1.10; 95% CI: 0.98–1.23) and those with underweight or normal weight (OR: 0.95; 95% CI: 0.81–1.05). Moreover, a non-linear relationship was found between BRI and the prevalence of CKD. In ROC analysis, BRI demonstrated higher discriminating for CKD (area under the curve: 0.6247; 95% CI: 0.6161–0.6333; optimal cutoff value: 5.161) compared with other indices.ConclusionIn summary, BRI was independently associated with a higher prevalence of CKD in overweight and obese US adults, excluding Mexican. This may be an important therapeutic target and predictor of CKD. Physicians should advise patients with high BRI scores, especially overweight and obese patients, to embrace healthy lifestyle changes, such as maintaining a balanced diet and engaging in regular physical activity. These changes can help them control their body weight and reduce abdominal fat, ultimately lowering the risk of CKD.
High-throughput screening of dual-target inhibitors for SARS-CoV-2 main protease and papain-like protease from Chebulae Fructus: in silico prediction and experimental verification
Authors: Wang Changjian , Cao Yipeng , Yang Qi , Wang Xinyue , Yang Zhiying , Yang Jingjing , Li Xinru , Li Bin , Wang Yuefei , Zhang Min 
Published: December 2024

BackgroundThe unavoidable propagation of the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has underscored the urgent requirement for efficacious therapeutic agents. The dried fruit of Terminalia chebula Retz., namely Chebulae Fructus, is widely used for treating bacterial and viral infectious diseases, which was witnessed to perform anti-SARS-CoV-2 activity in recommended Chinese patent medicine.AimSARS-CoV-2 main protease (Mpro) and papain-like protease (PLpro) present essential effects on SARS-CoV-2 replication and transcription, considering as the attractive targets for therapeutic intervention. In this study, we focused on the dual-target to obtain broad-spectrum antiviral candidates from Chebulae Fructus.MethodsThe identified compounds from Chebulae Fructus were used to build a library in a previous study, which were evaluated by molecular docking to screen potential antiviral agents. The SARS-CoV-2 Mpro and PLpro were expressed in E. coli cells and purified. Fluorescence resonance energy transfer (FRET) and surface plasmon resonance (SPR) were utilized to verify the affinity with dual targets. SARS-CoV-2 wild-type, Omicron BA.5 and Omicron EG.5 variants were employed to validate their antiviral activities in vitro. Molecular dynamics simulation was conducted via Gromacs 2022 software in 500 ns to unveil the conformation stability.ResultsTargeting on Mpro and PLpro, eight compounds were screened as the potential dual-target inhibitors in molecular docking. In FRET and SPR assays, 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) and 1,2,3,6-tetra-O-galloyl-β-D-glucose (TGG) showed good inhibitory activities with IC50 values ranging from 1.33 to 27.37 μM, and affinity with KD values ranging from 0.442 to 0.776 μM. Satisfactorily, both PGG and TGG display antiviral activity in vitro with EC50 values ranging from 3.20 to 37.29 μM, suggesting as the promising candidates against SARS-CoV-2. In molecular dynamics simulation study, the complexes of Mpro-PGG, Mpro-TGG, PLpro-PGG, and PLpro-TGG exhibited stability over 500 ns period, unveiling the potential interactions.ConclusionPGG and TGG are the promising dual-target inhibitors of SARS-CoV-2, which may avoid drug resistance and have a good development prospect. The outcomes of this study provide an effective strategy to systematically explore the antiviral bioactive compounds from Chebulae Fructus.
Trends in exercise therapy research for neurological diseases: a bibliometric and visualization approach from 2000 to 2024
Authors: Zhang Jiacheng , Zhu Lielie 
Published: December 2024

BackgroundNeurological disorders are one of the major global health burdens, and exercise therapy has been widely recognized as a beneficial intervention. However, the existing literature has primarily focused on summarizing the interventions, complications, and influencing factors, with relatively limited systematic comparisons and summaries.MethodsThis study employed a bibliometric analysis approach, using VOSviewer and CiteSpace software to analyze the literature on the application of exercise therapy in neurological disorders from 2000 to 2024, including annual publication volumes, countries/regions, institutions, authors, journals, keyword co-occurrences, keyword clustering, keyword timelines, and keyword bursts.ResultsThe study found that the United States is the leading contributor in this field, and the University of Toronto and the University of Illinois are the most active research institutions. Keyword analysis revealed that the research hotspots in this field are concentrated on the role of exercise therapy in the prevention, treatment, rehabilitation, and improvement of quality of life for neurological disorders, and are gradually delving into its potential physiological mechanisms.ConclusionThis study provides valuable references for subsequent research in this field, helping to track the research frontiers and predict future research directions. Future research could further explore the specific mechanisms and clinical efficacy for different neurological diseases, providing more targeted evidence for clinical practice.