bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction to Arman Grigoryan's “What is
Hamasteghtsakan Art” (1993) and “What is
Hamasteghtsakan Art” (1996)
Authors: Harutyunyan Angela 
Published: November 2019

Abstract
The document presents two separate articles with the same title –“What is Hamasteghtsakan Art” – by artist Arman Grigoryan and art critic Nazareth Karoyan, published in Armenia in 1994 and 1996 respectively. Translated from Armenian and introduced by Angela Harutyunyan both articles have been formative for the development of contemporary art in Armenia. While presenting diverging views on the meaning of hamasteghtsakan (translated as collectively created), the concept was circulated as a definition for a broad range of post-medium artistic practices in late Soviet and post-Soviet Armenia. These practices formed an oppositional discourse to both Socialist Realism and Armenian National modernism. Harutyunyan's introduction locates the texts in a broader context of artistic institutional transformations in the late 1980s and early 1994 in Armenia.
Behavior Morphologies of Machine Learning Agents in Media Artworks
Authors: Audry Sofian 
Published: November 2019

Abstract
Since the 1950s, a range of artists have used artificial agents in their work, in parallel with scientific research in cybernetics, artificial intelligence (AI) and artificial life (AL). In particular, an increasing number of artists work with machine learning and other adaptive systems. Through the author's own engagement with such systems, an analysis of adaptive agents is provided within the broader context of behavior aesthetics. As a result, the author proposes an aesthetic framework for understanding behaviors that accounts for the observer as an adaptive perceiving agent, the unfathomable character of machine learning systems and the morphology of behaviors as a time-based phenomenon.
Astrological Debates in Italian Renaissance Commentaries on Aristotle’s Meteorology
Authors: Martin Craig 
Published: November 2019

Abstract
From the time of Albertus Magnus, medieval commentators on Aristotle regularly used a passage from Meteorology 1.2 as evidence that the stars and planets influence and even govern terrestrial events. Many of these commentators integrated their readings of this work with the view that planetary conjunctions were causes of significant changes in human affairs. By the end of the sixteenth century, Italian Aristotelian commentators and astrologers alike deemed this passage as authoritative for the integration of astrology with natural philosophy. Giovanni Pico della Mirandola, however, criticized this reading, contending that Aristotle never used the science of the stars to explain meteorological phenomena. While some Italian commentators, such as Pietro Pomponazzi dismissed Pico’s contentions, by the middle of the sixteenth century many reevaluated the medieval integration. This reevaluation culminated in Cesare Cremonini, who put forth an extensive critique of astrology in which he argued against the idea of occult causation and celestial influence, as he tried to rid Aristotelianism of its medieval legacy.
Assessment and grading of pigmentation in chronic venous insufficiency
Authors: Tiwary Satyendra K , Kumar Praveen KG , Dhameeja Neeraj , Kumar Puneet , Khanna Ajay K , Khanna Soumya 
Published: November 2019

Introduction Chronic venous insufficiency causes skin pigmentation of the leg ranging from small patches of mild dyschromia to extensive areas of severe skin pigmentation. It is thought that the pigmentation is mainly due to haemosiderin or melanin deposition. Erythrodiapedesis which occurs as a result of venular hypertension causes erythrocytes to migrate across the microvascular network into the dermis. Methods We categorized the grading of pigmentation into four grades: +, few spots; ++, pigmentation over gaiter area; +++, pigmentation involving leg and ankle; ++++, heavily pigmented (dark). Skin biopsies were taken from the patient while undergoing surgery; two biopsies were taken from each patient, one from apparently normal skin and other from the site of pigmentation. A total of 45 patients diagnosed as chronic venous insufficiency with pigmentation were included in the study and five patients included in control. The biopsy specimens were sent to pathology department for H&E, Perls stain and IHC for S100. Results Majority of cases, i.e. 62% of limbs fall under (++) grade of pigmentation, followed by (+) grade of pigmentation in 20%, while (+++) and (++++) constitute 9% of the cases each. Increased melanin deposition was seen in 40 pigmented skin biopsies and 3 normal skin biopsies from the case group, and normal melanin deposition was seen in all the non-varicose controls. Conclusion We have tried to categorize pigmentation in chronic venous insufficiency into four grades. As the grade of pigmentation increases the per cent of cases with ulceration is increasing. It was observed that presence of melanin deposition irrespective of the grade of pigmentation was distributed more towards the advanced clinical classification (C5 and C6).
Aztreonam, Ceftazidime/Avibactam, and Colistin Combination for the Management of Carbapenemase-Producing Klebsiella Pneumoniae Bacteremia: A Case Report
Authors: Shah Punit J. , Tran Thuytram , Emelogu Francis , Tariq Farheen 
Published: November 2019

Purpose: A case of a patient with sepsis from a urinary source due to carbapenemase-producing Klebsiella pneumoniae treated with a novel combination of aztreonam, ceftazidime/avibactam, and colistin is described. Summary: An 80-year-old South Asian male presented to the hospital with sepsis from a urinary source. Blood and urine cultures were positive for a carbapenemase-producing K pneumoniae sensitive only to colistin and tigecycline. Novel beta-lactamase inhibitor combinations ceftazidime/avibactam and meropenem/vaborbactam were resistant. Patient was initially on ceftazidime/avibactam and colistin combination followed by tigecycline and colistin with lack of improvement. Metallo-beta-lactamase (MBL)-producing K pneumoniae was suspected based on the sensitivity pattern and history of medical treatment in India. Patient was then initiated on novel combination of ceftazidime/avibactam, aztreonam, and colistin. Patient’s white blood cell (WBC) count and fever curve normalized. Unfortunately, the patient failed to recover completely likely because of his multiple comorbidities and declining functional status, resulting in the family’s decision to pursue hospice. Conclusion: The combination of ceftazidime/avibactam and aztreonam should be considered as a viable treatment option for patients with infections caused by MBL-producing Enterobacteriaceae.
Cerebrospinal fluid complement system biomarkers in demyelinating disease
Authors: Zelek Wioleta Milena , Fathalla Dina , Morgan Angharad , Touchard Samuel , Loveless Samantha , Tallantyre Emma , Robertson Neil P , Morgan B Paul 
Published: November 2019

Background: Multiple sclerosis (MS) can be difficult to differentiate from other demyelinating diseases, notably neuromyelitis optica spectrum disorder (NMOSD). We previously showed that NMOSD is distinguished from MS by plasma complement biomarkers. Objective: Here, we measure cerebrospinal fluid (CSF) complement proteins in MS, NMOSD and clinically isolated syndrome (CIS), a neurological episode that may presage MS, to test whether these distinguish NMOSD from MS and CIS. Materials and methods: CSF (53 MS, 17 CIS, 11 NMOSD, 35 controls) was obtained; complement proteins (C4, C3, C5, C9, C1, C1q, Factor B (FB)), regulators (Factor I (FI), Factor H (FH), FH-Related Proteins 1, 2 and 5 (FHR125), C1 Inhibitor (C1INH), Properdin) and activation products (terminal complement complex (TCC), iC3b) were quantified by ELISA and results expressed relative to CSF total protein (μg/mg). Results: Compared to control CSF, (1) levels of C4, C1INH and Properdin were elevated in MS; (2) TCC, iC3b, FI and FHR125 were increased in CIS; and (3) all complement biomarkers except TCC, FHR125, Properdin and C5 were higher in NMOSD CSF. A statistical model comprising six analytes (C3, C9, FB, C1q, FI, Properdin) plus age/gender optimally differentiated MS from NMOSD.
Tele-rehabilitation and hospital-based cardiac rehabilitation are comparable in increasing patient activation and health literacy: A pilot study
Authors: Knudsen Marie V , Petersen Annemette K , Angel Sanne , Hjortdal Vibeke E , Maindal Helle T , Laustsen Sussie 
Published: November 2019

Background: Cardiac tele-rehabilitation is defined as using information and communication technology to support rehabilitation services. However, it requires a high level of patient activation and health literacy; this has not yet been explored. Aims: The purpose of this study was to evaluate patient activation and health literacy in tele-rehabilitation compared to hospital-based cardiac rehabilitation. Methods: We conducted a pilot study in patients with ischaemic or heart valve disease. In a non-randomised design, 24 patients attended a 12-week tele-rehabilitation programme, and 53 matched controls a 12-week hospital-based cardiac rehabilitation programme. The primary outcome was patient activation, which was assessed using the Patient Activation Measure before the intervention, at the end of the intervention and at follow-up six months after the intervention. The secondary outcome was health literacy, assessed using three dimensions from the Health Literacy Questionnaire before rehabilitation and at six-month follow-up: actively manage my health (HLQ3), ability to engage with healthcare providers (HLQ6) and understanding health information (HLQ9). Results: Patient activation improved similarly in tele-rehabilitation and hospital-based cardiac rehabilitation at all time points. Six months after the intervention, patients in tele-rehabilitation significantly improved on the dimension HLQ6 compared to patients in hospital-based cardiac rehabilitation. No significant between-group differences were found in HLQ3 or HLQ9. Conclusion: Tele-rehabilitation and hospital-based cardiac rehabilitation seemed to be equally successful in improving patient activation and health literacy. Tele-rehabilitation should be further tested in a randomised controlled trial, with a focus on whether patient levels of education and self-management at the initiation of rehabilitation are decisive factors for tele-rehabilitation participation.
Epidemiology and Trends of Hereditary Hemorrhagic Telangiectasia in the United States
Authors: Ferry Andrew M. , Wright Alex E. , Baillargeon Gwen , Kuo Yong-Fang , Chaaban Mohamad R. 
Published: November 2019

BackgroundTo our knowledge, no national studies have investigated the epidemiology of hereditary hemorrhagic telangiectasia (HHT) in the United States since the incorporation of the International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Clinical Modification (ICD-10 CM).ObjectiveOur objective is to analyze the epidemiology of HHT from 2013 to 2017 and to determine the relationships between epistaxis and other associated complications of this rare disease.MethodsWe analyzed the epidemiology of HHT between 2013 and 2017 by accessing data of 87 709 738 patients from the Clinformatics Data Mart using ICD-9 CM and ICD-10 CM codes. Variables analyzed included age, gender, region, clinical setting of diagnosis, hospitalizations, and complications. Bivariate analyses using generalized linear models were conducted to determine the likelihood of HHT patients with epistaxis enduring associated life-threatening complications such as cerebral hemorrhage, thrombosis, and pulmonary hemorrhage compared to HHT patients without epistaxis during the study period.ResultsThe prevalence of HHT increased from 6.1 to 12.1 per 100 000 persons, with patients of ages 18 to 29 years and those older than 60 years seeing the greatest percent increase. The prevalence of HHT in the Southern United States saw a 147% increase. Compared to HHT patients without epistaxis, HHT patients with epistaxis were 3.4 times more likely to experience pulmonary hemorrhage, 3.3 times more likely to have pulmonary emboli, 2.8 times more likely to experience cerebral hemorrhage, and 2.0 times more likely to have thrombosis during the study period.ConclusionOur national study has provided the first incidence and prevalence rates of HHT in the United States since the incorporation of the ICD-10 CM. HHT patients with epistaxis require prompt multidisciplinary treatment of their condition due to their increased risk of life-threatening complications.
A novel clinical practice tool increases patients’ understanding of concussion care within an inter-disciplinary clinic
Authors: Bauman Shannon M , MacDonald Julie , Glatt Carolyn , Doktor-Inglis Iveta , McLean Jesse 
Published: November 2019

Background Concussion patients who experience prolonged symptoms may benefit from evidence-based, physician-led, inter-disciplinary care. The success of this approach may depend on a patient’s understanding and adherence to a complex, multi-modal recovery process. Objectives We have developed a novel clinical care guide for post-injury concussion caretermed the “Treatment Passport,” intended to facilitate greater communication and understanding among patients, healthcare providers, family members, teachers, and coaches. This study aims to assess whether the Treatment Passport increases patients’ understanding of their concussion care in an inter-disciplinary setting. Methods Patients presenting with sports- or recreation-related concussions were randomly assigned to the intervention ( n = 15) or control ( n = 18) group. Subjects in the control group received physician-led, inter-disciplinary care, while subjects in the intervention group received the same care, but with the addition of the Treatment Passport. After four weeks of treatment, participants in both groups completed an 11-question survey to assess their understanding of inter-disciplinary concussion care. Results The median age of participants was 20 (range 10–63). Participants in the intervention group showed significant increases in their understanding of inter-disciplinary concussion care when compared to control group members. This was reflected in a 2.1–2.8-fold greater understanding of the cognitive, physical, and vestibular aspects of their care. In addition, 86.7% of control group participants indicated they believed that the Treatment Passport would have helped with their concussion recovery journey. Conclusion The Treatment Passport is a novel clinical tool that facilitates the delivery of standardized inter-disciplinary concussion care by increasing patient-caregiver communication and understanding.
PAK4, a target of miR-9-5p, promotes cell proliferation and inhibits apoptosis in colorectal cancer
Authors: Wang Meihua , Gao Qianqian , Chen Yufang , Li Ziyan , Yue Lingping , Cao Yun 
Published: November 2019

Abstract

Background
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. P21-activated kinase 4 (PAK4) and miR-9-5p have emerged as attractive therapeutic targets in several tumor types, but in CRC, the regulation of their biological function and their target association remain unclear.

Methods
The expression of PAK4 in CRC tissues was determined using quantitative real-time PCR and immunohistochemistry analyses. The targeted regulation between miR-9-5p and PAK4 was predicted and confirmed with bioinformatics analysis and the dual-luciferase reporter assay. Functional experiments, including the MTT assay and flow cytometry, were performed to investigate the impact of PAK4 knockdown and miR-9-5p overexpression on cell proliferation and apoptosis in CRC cells.

Results
We found that the expression of PAK4 was upregulated in CRC tissues. PAK4 knockdown significantly suppressed cell proliferation and promoted apoptosis in cells of the CRC cell lines HCT116 and SW1116. We also found that miR-9-5p directly targeted the 3′-UTR of PAK4 mRNA and negatively regulated its expression. The degree of downregulation of miR-9-5p inversely correlated with PAK4 expression. Intriguingly, enforced expression of miR-9-5p suppressed cell proliferation and promoted apoptosis. This could be partially reversed by PAK4 overexpression.

Conclusion
These results suggest that miR-9-5p targeting of PAK4 could have therapeutic potential for CRC treatment.
Influence of drivers’ visual and cognitive attention on their perception of changes in the traffic environment
Authors: Cvahte Ojsteršek Tina , Topolšek Darja 
Published: November 2019

Abstract
Drivers are met with numerous elements requiring their attention while driving. The present research focuses on selected visual and cognitive distractions that the driver is faced with, and on their influence on detecting and perceiving changes in the traffic environment. Driver self evaluation data was used to define which elements attract most visual and cognitive distraction. A constructed conceptual model was subjected to analysis using Exploratory factor analysis (EFA), Confirmatory factor analysis (CFA), and Structural Equation Modelling (SEM). Main findings show that thinking about personal problems, chores and errands as well as roadside advertisements on the cognitive side, and looking at advertisements and the natural environment on the visual side, present the most negative impacts on drivers’ perception of crucial changes in the traffic environment. On the other hand, drivers that visually focus on traffic signals and pedestrians and think about driving speed, driving rules, and other traffic participants, tend to notice crucial changes in the traffic environment more often.
Assessment of long-term sickness absence: content and face validity of a new questionnaire based on qualitative data from nominal groups
Authors: Goorts Kaat , Vanovenberghe Charlotte , Lambreghts Charlotte , Bruneel Eline , Rusu Dorina , Du Bois Marc , Vandenbroeck Sofie , Godderis Lode 
Published: November 2019

AbstractBackgroundIncreasing rates of long-term sickness absence are a worldwide problem. Belgium is the first country in Europe that aims to screen its entire population of sick leavers (sick leave > 6 weeks) for the risk of long-term sickness absence in order to focus resources on the high-risk group and to provide adequate return-to-work support. Our aim was to investigate content and face validity of a newly designed questionnaire (Quickscan) using item prioritization of patients and professionals in the field of long-term sickness absence. This questionnaire was developed based on a review of the literature and existing instruments (Goorts et al, J Public Health Res 7:1419, 2018).MethodsQualitative data were collected using the nominal group technique. The data were gathered exploring factors that influence return-to work restrictions or opportunities.ResultsParticipants indicated 20 out of 21 of the questionnaire factors as important reasons that might influence the return-to-work process. Additionally, 16 factors were discussed that were not yet included in the Quickscan but that might provide useful information on return-to-work issues, according to the participants. In the prioritization of items, we found considerable diversity among participants.ConclusionsOur findings demonstrate the validity of the Quickscan items to ask patients about important return-to-work barriers or opportunities. However, additional factors were identified that may improve the assessment of risk for long-term sickness absence.
Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer
Authors: Sheng Hui , Wei Xiaoli , Mao Minjie , He Jincan , Luo Tianqi , Lu Shilin , Zhou Liye , Huang Zhixin , Yang Anli 
Published: November 2019

Abstract

Background
Although numerous studies have investigated the clinicopathologic and prognostic relevance of mucinous adenocarcinoma (MAC) and signet-ring cell carcinoma (SRCC) compared with classic adenocarcinoma (CA), little is known about the prognosis of adenocarcinoma with mixed subtypes (AM) and the differences among these four subtypes.

Methods
The statistics of colorectal cancer registered in the Surveillance, Epidemiology and End Results (SEER) database were retrieved and analyzed. We also compared the clinicopathologic and prognostic relevance between CA, SRCC, MAC, and AM.

Results
The frequencies of these four subtypes were 69.9% (CA, n = 15,812), 25.1% (MAC, n = 5689), 3.6% (SRCC, n = 814) and 1.4% (AM, n = 321), respectively. All of MAC, SRCC, and AM were significantly related with aggressive features. Only SRCC and AM were identified as independent poor prognostic markers for overall survival by multivariate analysis. The aggressiveness of AM was between MAC and SRCC according to the clinicopathologic associations. The prognosis of AM was significantly worse than MAC but comparable with SRCC.

Conclusions
We confirmed the clinicopathologic relevance with aggressive features of MAC and SRCC, as well as poor prognostic relevance of SRCC by analyzing a large study population data set. Furthermore, we identified AM as a rare but aggressive histologic subtype in colorectal cancer, to which particular attention should be given in clinical practice.
The distribution of Preputial vessels in different severity of rat congenital hypospadias model: imaging study using micro-computerized tomography
Authors: Lin Defu , Liu Pei , Wang Guannan , Zhang Weiping , Sun Ning 
Published: November 2019

Abstract

Background
Micro-computerized tomography (micro-CT) is considered as an innovative non-invasive and high-resolution imaging technology. The current research aims to reconstruct the distribution of preputial vessels in different severity of rat congenital hypospadias model by micro-CT, and to provide an anatomic basis for the selection of preputial vessel pedicle flaps in surgery.

Methods
Pregnant rats were exposed to finasteride from gestational day 12 to 17. Depending on the position of the urethral meatus, the pups were divided into normal, mild hypospadias and severe hypospadias groups. Six months after birth, the preputial blood vessels were observed in vascular perfusion with Microfil (a silicone-based polymer) and scanned by micro-CT. CTvox and NRecon were utilized to reconstruct 3-dimentional (3D) images. A pathological analysis of the specimen was taken in order to determine the position of Microfil.

Results
The normal group and the mild hypospadias group had similar preputial image characteristics. At the junction of the inner and outer prepuce, the deep layer vessels of the superficial fascia were transversely distributed and formed a vascular ring-like structure. Among the severe hypospadias group, five had sufficient blood circulation while six had insufficient blood circulation. In sufficient blood circulation type, the ring-like vessels were found at the junction of the inner and outer prepuce similar to that of the normal and mild hypospadias group. However, only a small amount of capillary supply to this area in the insufficient type.

Conclusion
The junction of the inner and outer prepuce with abundant blood circulation was suitable to be a vascular pedicle flap. The tubularized preputial island flaps were consistent with the ring-like vessels area, and the original blood supply was retained to the greatest extent.