bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructing identity through commemoration:Kwibukaand the rise of survivor nationalism in post-conflict Rwanda
Authors: Baldwin Gretchen 
Published: October 2019

AbstractIn the years following Rwanda's civil war, the country has remembered those killed in the 1994 genocide with 100 days of official commemoration, known as Kwibuka. The temporary commemoration period is characterised by an explicit acknowledgement and public discussion of ethnic identity, which stands in puzzling contrast to the state's policy of ethnic non-recognition, enforced during the rest of the year in hopes of achieving national homogeneity (Ndi Umunyarwanda). Thus, one observes seemingly diametrically opposed practices of legally erasing identity groups because of their link to conflict and a unique, three month-long saturation of reminders in the form of public speeches, memorial programming and burials, and commemorative signage. A blurring of ‘Tutsi’ with ‘survivor’ and the deliberate passing down of survivor identity to Tutsi youth have created, over time, conditions for a ‘survivor nationalism’, which exacerbates social tensions and risks sustainable peace in the long term.
Barriers and facilitators to accessing psychological therapies for severe mental health difficulties in later life
Authors: Berry Katherine , Sheardown Jennifer , Pabbineedi Uma , Haddock Gillian , Cross Catherine , Brown Laura J.E. 
Published: October 2019

AbstractBackground:The number of people growing older with severe mental illness (SMI) is rising, reflecting societal trends towards an ageing population. Evidence suggests that older people are less likely to seek help, be referred for and receive psychological therapy compared with younger people, but past research has focused on those with mild to moderate mental health needs.Aims:This research aims to identify the specific barriers faced by older people with SMI.Method:We interviewed 53 participants (22 service users with SMI aged over 50 years, 11 carers of people with SMI, and 20 health care professionals) about their views and experiences of accessing therapy for SMI in later life.Results:Thematic analysis revealed five themes: organizational and resource issues; myths about therapy and attitudinal barriers; stigma; encouraging access to therapy; and meeting age-specific needs.Conclusions:Barriers faced by older people with SMI are not only age-related, but also reflect specific issues associated with having a SMI over many years. Improving awareness of the benefits of psychological therapies is important not only for older people with SMI themselves, but also for their carers and staff who work with them.
Electrochemical Behavior of Carbon Electrodes for In Situ Redox Studies in a Transmission Electron Microscope
Authors: Girod Robin , Nianias Nikolaos , Tileli Vasiliki 
Published: October 2019

AbstractElectrochemical liquid cell transmission electron microscopy (TEM) is a unique technique for probing nanocatalyst behavior during operation for a range of different electrocatalytic processes, including hydrogen evolution reaction (HER), oxygen evolution reaction (OER), oxygen reduction reaction (ORR), or electrochemical CO2 reduction (eCO2R). A major challenge to the technique's applicability to these systems has to do with the choice of substrate, which requires a wide inert potential range for quantitative electrochemistry, and is also responsible for minimizing background gas generation in the confined microscale environment. Here, we report on the feasibility of electrochemical experiments using the standard redox couple Fe(CN)63−/4− and microchips featuring carbon-coated electrodes. We electrochemically assess the in situ performance with respect to flow rate, liquid volume, and scan rate. Equally important with the choice of working substrate is the choice of the reference electrode. We demonstrate that the use of a modified electrode setup allows for potential measurements relatable to bulk studies. Furthermore, we use this setup to demonstrate the inert potential range for carbon-coated electrodes in aqueous electrolytes for HER, OER, ORR, and eCO2R. This work provides a basis for understanding electrochemical measurements in similar microscale systems and for studying gas-generating reactions with liquid electrochemical TEM.
Birth size and cancer prognosis: a systematic review and meta-analysis
Authors: Sharma Shantanu , Kohli Charu , Johnson Linda , Bennet Louise , Brusselaers Nele , Nilsson Peter M. 
Published: October 2019

AbstractThere is an established link between birth parameters and risk of adult-onset cancers. The Developmental Origins of Health and Disease concept provides potential underlying mechanisms for such associations, including intrauterine exposure to endogenous hormones (androgens and estrogens), insulin-like growth factors, etc. However, there is conflicting evidence on the association between birth parameters and the cancer mortality risk. Therefore, we aimed to review and analyse the available data on the association linking birth weight and birth length with cancer mortality. Eleven studies were identified, published until April 2019. A significant association between birth weight and the prognosis of cancer (overall) was found (relative risk, RR 1.06, 95% confidence interval, CI: 1.01, 1.11), with low heterogeneity (I2 = 27.7%). In addition, higher birth weight was associated with poorer prognosis of prostate cancer (RR 1.21, 95% CI: 1.02, 1.44). However, the association of birth weight with breast cancer mortality risk in women was not significant (RR 1.16, 95% CI: 0.93, 1.44), which might be due to high statistical heterogeneity (I2 = 67.9%). Birth length was not associated with cancer mortality risk (RR 1.0, 95% CI: 0.90–1.11). It might be inferred that birth parameters are not associated with cancer mortality as strongly as with the risk of developing cancer. Also, the association between birth parameters and cancer mortality risk is not uniform and varies according to its subtypes, and study characteristics/design. This highlights the need for further prospective studies.
From Breakup of Nuna to Assembly of Rodinia: A Link Between the Chinese Central Tianshan Block and Fennoscandia
Authors: Huang Zongying , Yuan Chao , Long Xiaoping , Zhang Yunying , Du Long 
Published: October 2019

AbstractThe transition from breakup of Nuna (or Columbia, 2.0–1.6 Ga) to assembly of Rodinia (1.0–0.9 Ga) is investigated by means of U‐Pb and Lu‐Hf data of detrital zircons from three Neoproterozoic metasedimentary rocks in the Central Tianshan Block (CTB), NW China. These data yield six age peaks around 1.0, 1.13, 1.34, 1.4–1.6, 1.75, and 2.6 Ga. Few zircons are detected between 2.0 and 2.5 Ga. The Paleoproterozoic to Neoproterozoic detrital zircons have Hf isotopic compositions (−22.1 to +13.0) similar to those of coeval magmatic rocks in the CTB, indicating a proximal provenance. These results, together with the geological evidence and the presence of 1.4 Ga orogenic granitoids in the CTB, rule out most cratons as the CTB sources but support a Fennoscandia ancestry. Zircon U‐Pb ages and Hf isotopic compositions from the CTB and Fennoscandia suggest that from 1.8 to 1.4 Ga, theεHf(t) values increased toward more positive values, consistent with an exterior orogen characteristic that the lower crust was replaced by a juvenile arc crust. In contrast, from 1.4 to 0.9 Ga, zirconεHf(t) values decreased to more negative values, reflecting an interior orogen, characterized by enhanced contribution of recycled crustal material from collided continental fragments. This marked shift most likely reflected a transition from breakup of Nuna to assembly of Rodinia, accomplished by a transformation from an exterior orogen to an interior one.
Ocean Observatories as a Tool to Advance Gas Hydrate Research
Authors: Scherwath M. , Thomsen L. , Riedel M. , Römer M. , Chatzievangelou D. , Schwendner J. , Duda A. , Heesemann M. 
Published: October 2019

AbstractSince 2009, unprecedented comprehensive long‐term gas hydrate observations have become available from Ocean Networks Canada's NEPTUNE cabled ocean observatory at the northern Cascadia margin. Several experiments demonstrate the scientific importance of permanent power and Internet connectivity to the ocean floor as they have advanced the field of gas hydrate related research. One example is the cabled crawler Wally at Barkley Canyon, enabling live in situ exploration of the hydrate mounds and its associated benthic communities through the crawler's mobility and permanent accessibility throughout the year. Another example is a bubble‐imaging sonar at Clayoquot Slope, revealing the strong relationship between ebullition of natural gas and tidal pressure, without apparent correlation to earthquakes, storms, or temperature fluctuations, in year‐long continuous recordings. Finally, regular observatory maintenance cruises allow additional science sampling including echo‐sounder surveys to extend the observatory footprint. Long‐term trends in the data are not yet apparent but can also become evident from continuous measurements, as ocean observatories such as NEPTUNE are built for a 25‐year lifetime, and expansion of the observatory networks makes these findings comparable and testable.
Episodic Extrema of Surface Stress Energy Input to the Western Arctic Ocean Contributed to Step Changes of Freshwater Content in the Beaufort Gyre
Authors: Zhong Wenli , Zhang Jinlun , Steele Michael , Zhao Jinping , Wang Tao 
Published: October 2019

AbstractThe recent dramatic decline of sea ice in the western Arctic Ocean changes the transfer of momentum across the ice‐ocean boundary layer. The surface stress energy input through the surface geostrophic current in the Beaufort Gyre (BG) based on a numerical model is 0.03 mW/m2 in 1992–2004 versus 0.23 mW/m2 in 2005–2017. This energy input is primarily concentrated over the southern Canada Basin and the Chukchi Sea. It is 1.38 × 1016 J in observations versus 4.90 × 1016 J in the model in the BG during 2003–2014. We find that some well‐known freshwater changes in the BG over 1992–2017 resulted from episodic extrema of energy input in 2007, 2012, and 2016. In particular, most of the energy input in 2007 was transformed into potential energy (57%) which resulted in a new state of freshwater budget. Our study suggests that as of 2016, the BG had not yet reached a saturated freshwater state.
Mean Structure and Seasonality of the Norwegian Atlantic Front Current Along the Mohn Ridge From Repeated Glider Transects
Authors: Bosse Anthony , Fer Ilker 
Published: October 2019

AbstractThe poleward flow of Atlantic Water in the Nordic Seas forms the upper limb of the meridional overturning circulation driving an important heat transport. The Norwegian Atlantic Front Current along the Mohn Ridge between the Greenland and Norwegian Seas is characterized for the first time, using repeated sections over 14 months from autonomous underwater gliders and two research cruises. The Norwegian Atlantic Front Current follows the 2,550‐m isobath with a width of 38 ± 2 km and absolute geostrophic velocities peaking at 0.56 ± 0.03 m s−1. The mean transport of Atlantic Water is 3.2 ± 0.2 Sv (equivalent to temperature transport of 71 ± 5 TW). Seasonal variability was observed with a magnitude of 0.8 Sv and maximum values in the fall. The deep currents at 1,000 m explained most of this seasonal variation and were anticorrelated with time‐integrated wind stress curl over the Lofoten Basin. Part of this flow might recirculate within the Lofoten Basin, while the rest continues toward the Arctic.
Long-term survival in patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed therapy
Authors: Beckham Thomas H. , Leeman Jonathan E. , Xie Peng , Li Xiaolin , Goldman Debra A. , Zhang Zhigang , Sherman Eric , McBride Sean , Riaz Nadeem , Lee Nancy , Tsai C. Jillian 
Published: October 2019

Abstract

Background
Our objective was to evaluate the outcomes of metastatic head and neck squamous cell carcinoma (HNSCC) by disease burden with an emphasis on metastasis-directed therapy (MDT) in patients with limited metastatic disease burden.

Methods
In total, 186 patients who developed metastatic disease after definitive therapy for HNSCC were included. Clinically and radiographically apparent metastases were enumerated. Kaplan–Meier methods were used to estimate survival. Cox regression was used to assess the association between clinical variables.

Results
Patients with a single metastasis had a 5-year overall survival (OS) of 35% (95% CI 16–54%) in contrast to patients with multiple metastases with a 5-year OS of 4% (95% CI 2–9%). Thirty patients (16.1%) underwent MDT. On multivariable analysis, oral cavity or sinonasal primary (HR 2.22 95% CI 1.16–4.25, p = 0.015; HR 4.88, 95% CI 1.10–21.70, p = 0.037, respectively) were associated with higher risk of death, whereas receipt of MDT (HR 0.36, 95% CI 0.17–0.74, p = 0.006) was associated with lower hazard of death. Median subsequent metastasis-free survival and 5-year survival after MDT (n = 30) were estimated at 26.4 months (95% CI: 9.8–54.0) and 31%, (95% CI: 15–48%).

Conclusions
HNSCC patients with limited metastatic disease may derive significant benefit from MDT. Prospective trials evaluating MDT in HNSCC are warranted.
An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses
Authors: Longet Stephanie , Abautret-Daly Aine , Davitt Christopher J. H. , McEntee Craig P. , Aversa Vincenzo , Rosa Monica , Coulter Ivan S. , Holmgren Jan , Raghavan Sukanya , Lavelle Ed C. 
Published: October 2019

AbstractHelicobacter pyloricauses chronic gastric infection that can lead to peptic ulcers and is an identified risk factor for gastric cancer development. Although much effort has been put into the development of aHelicobacter pylorivaccine over the last three decades, none has yet reached clinical application. Specific challenges pertaining to effectiveH. pylorivaccine development include the lack of proven vaccine-effective antigens and safe mucosal adjuvants to enhance local immune responses as well as the lack of accepted correlates of protection. Herein, we demonstrate that prophylactic intragastric immunisation with a whole-cell killedH. pyloriantigen administered together with the non-toxic oral adjuvant α-galactosylceramide (α-GalCer) induced effective immune protection againstH.pylori infection in mice, which was of similar magnitude as when using the “gold standard” cholera toxin as adjuvant. We further describe that this α-GalCer-adjuvanted vaccine formulation elicited strong intestinal and systemic Th1 responses as well as significant antigen-specific mucosal and systemic antibody responses. Finally, we report that the protective intestinal Th1 responses induced by α-GalCer are dependent on CD1d, IL-1R as well as IL-17R signalling. In summary, our results show that α-GalCer is a promising adjuvant for inclusion in an oral vaccine againstH. pyloriinfection.
Integrated open-source software for multiscale electrophysiology
Authors: Nasiotis Konstantinos , Cousineau Martin , Tadel François , Peyrache Adrien , Leahy Richard M. , Pack Christopher C. , Baillet Sylvain 
Published: October 2019

AbstractThe methods for electrophysiology in neuroscience have evolved tremendously over the recent years with a growing emphasis on dense-array signal recordings. Such increased complexity and augmented wealth in the volume of data recorded, have not been accompanied by efforts to streamline and facilitate access to processing methods, which too are susceptible to grow in sophistication. Moreover, unsuccessful attempts to reproduce peer-reviewed publications indicate a problem of transparency in science. This growing problem could be tackled by unrestricted access to methods that promote research transparency and data sharing, ensuring the reproducibility of published results. Here, we provide a free, extensive, open-source software that provides data-analysis, data-management and multi-modality integration solutions for invasive neurophysiology. Users can perform their entire analysis through a user-friendly environment without the need of programming skills, in a tractable (logged) way. This work contributes to open-science, analysis standardization, transparency and reproducibility in invasive neurophysiology.
A dataset on human perception of and response to wildfire smoke
Authors: Fowler Mariah , Modaresi Rad Arash , Utych Stephen , Adams Andrew , Alamian Sanazsadat , Pierce Jennifer , Dennison Philip , Abatzoglou John T. , AghaKouchak Amir , Montrose Luke , Sadegh Mojtaba 
Published: October 2019

AbstractWildfire smoke presents a growing threat in the Western U.S.; and human health, transportation, and economic systems in growing western communities suffer due to increasingly severe and widespread fires. While modelling wildfire activity and associated wildfire smoke distributions have substantially improved, understanding how people perceive and respond to emerging smoke hazards has received little attention. Understanding and incorporating human perceptions of threats from wildfire smoke is critical, as decision-makers need such information to mitigate smoke-related hazards. We surveyed 614 randomly selected people (in-person) across the Boise Metropolitan Area in Idaho and 1,623 Boise State University affiliates (online), collecting information about their level of outside activity during smoke event(s), knowledge about the source of air quality information and effective messaging preference, perception of wildfire smoke as a hazard, and smoke-related health experiences. This relatively large dataset provides a novel perspective of people’s perception of smoke hazards, and provides crucial policy-relevant information to decision-makers. Dataset is available to the public and can be used to address a wide range of research questions.
An uncharacterized region within the N-terminus of mouse TMC1 precludes trafficking to plasma membrane in a heterologous cell line
Authors: Soler D. C. , Manikandan M. , Gopal S. R. , Sloan A. E. , McCormick T. S. , Stepanyan R. 
Published: October 2019

AbstractMechanotransduction by hair cell stereocilia lies at the heart of sound detection in vertebrates. Considerable effort has been put forth to identify proteins that comprise the hair cell mechanotransduction apparatus. TMC1, a member of the transmembrane channel-like (TMC) family, was identified as a core protein of the mechanotransduction complex in hair cells. However, the inability of TMC1 to traffic through the endoplasmic reticulum in heterologous cellular systems has hindered efforts to characterize its function and fully identify its role in mechanotransduction. We developed a novel approach that allowed for the detection of uncharacterized protein regions, which preclude trafficking to the plasma membrane (PM) in heterologous cells. Tagging N-terminal fragments of TMC1 with Aquaporin 3 (AQP3) and GFP fusion reporter, which intrinsically label PM in HEK293 cells, indicated that residues at the edges of amino acid sequence 138–168 invoke intracellular localization and/or degradation. This signal is able to preclude surface localization of PM protein AQP3 in HEK293 cells. Substitutions of the residues by alanine or serine corroborated that the information determining the intracellular retention is present within amino acid sequence 138–168 of TMC1 N-terminus. This novel signal may preclude the proper trafficking of TMC1 to the PM in heterologous cells.
Thermo-mechanical contact problems and elastic behaviour of single and double sides functionally graded brake disks with temperature-dependent material properties
Authors: Bayat Mehdi , Alarifi Ibrahim M. , Khalili Ali Akbar , El-Bagory Tarek M. A. A. , Nguyen Hoang Minh , Asadi Amin 
Published: October 2019

AbstractA thermo-elastic contact problem of functionally graded materials (FGMs) rotating brake disk with different pure brake pad areas under temperature dependent material properties is solved by Finite Element Method (FEM). The properties of brake disk change gradually from metal to ceramic by power-law distribution along the radial direction from the inner to the outer surface. Areas of the pure pad are changing while the vertical force is constant. The ratio of brake pad thickness to FGMs brake disk thickness is assumed 0.66. Two sources of thermal loads are considered: (1) Heat generation between the pad and brake disk due to contact friction, and (2) External thermal load due to a constant temperature at inner and outer surfaces. Mechanical responses of FGMs disk are compared with several pad contact areas. The results for temperature-dependent and temperature-independent material properties are investigated and presented. The results show that the absolute value of the shear stress in temperature-dependent material can be greater than that for temperature-independent material. The radial stress for some specific grading index (n = 1.5) is compressive near the inner surface for double contact while it is tensile for a single contact. It is concluded that the radial strain for some specific value of grading index (n = 1) is lower than other FGMs and pure double side contact brake disks.
Predation risk induces age- and sex-specific morphological plastic responses in the fathead minnow Pimephales promelas
Authors: Meuthen Denis , Ferrari Maud C. O. , Lane Taylor , Chivers Douglas P. 
Published: October 2019

AbstractAlthough comprehending the significance of phenotypic plasticity for evolution is of major interest in biology, the pre-requirement for that, the understanding of variance in plasticity, is still in its infancy. Most researchers assess plastic traits at single developmental stages and pool results between sexes. Here, we study variation among sexes and developmental stages in inducible morphological defences, a well-known instance of plasticity. We raised fathead minnows,Pimephales promelas, under different levels of background predation risk (conspecific alarm cues or distilled water) in a split-clutch design and studied morphology in both juveniles and adults. In accordance with the theory that plasticity varies across ontogeny and sexes, geometric morphometry analyses revealed significant shape differences between treatments that varied across developmental stages and sexes. Alarm cue-exposed juveniles and adult males developed deeper heads, deeper bodies, longer dorsal fin bases, shorter caudal peduncles and shorter caudal fins. Adult alarm cue-exposed males additionally developed a larger relative eye size. These responses represent putative adaptive plasticity as they are linked to reduced predation risk. Perhaps most surprisingly, we found no evidence for inducible morphological defences in females. Understanding whether similar variation occurs in other taxa and their environments is crucial for modelling evolution.