bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state
Authors: Roest Alison Schroer Vander , Liu Chao , Morck Makenna M , Kooiker Kristina Bezold , Jung Gwanghyun , Song Dan , Dawood Aminah , Jhingran Arnav , Pardon Gaspard , Ranjbarvaziri Sara , Fajardo Giovanni , Zhao Mingming , Campbell Kenneth S , Pruitt Beth L , Spudich James A , Ruppel Kathleen M , Bernstein Daniel 
Published: November 2020

AbstractHypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, associated with over 1000 mutations, many in β-cardiac myosin (MYH7). Molecular studies of myosin with different HCM mutations have revealed a diversity of effects on ATPase and load-sensitive rate of detachment from actin. It has been difficult to predict how such diverse molecular effects combine to influence forces at the cellular level and further influence cellular phenotypes. This study focused on the P710R mutation that dramatically decreased in vitro motility velocity and actin-activated ATPase, in contrast to other MYH7 mutations. Optical trap measurements of single myosin molecules revealed that this mutation reduced the step size of the myosin motor and the load sensitivity of the actin detachment rate. Conversely, this mutation destabilized the super-relaxed state in longer, two-headed myosin constructs, freeing more heads to generate force. Micropatterned hiPSC-cardiomyocytes CRISPR-edited with the P710R mutation produced significantly increased force (measured by traction force microscopy) compared with isogenic control cells. The P710R mutation also caused cardiomyocyte hypertrophy and cytoskeletal remodeling as measured by immunostaining and electron microscopy. Cellular hypertrophy was prevented in the P710R cells by inhibition of ERK or Akt. Finally, we used a computational model that integrated the measured molecular changes to predict the measured traction forces. These results confirm a key role for regulation of the super-relaxed state in driving hypercontractility in HCM with the P710R mutation and demonstrate the value of a multiscale approach in revealing key mechanisms of disease.Significance StatementHeart disease is the leading cause of death worldwide, and hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, affecting over 1 in 200 people. Mutations in myosin, the motor protein responsible for contraction of the heart, are a common cause of HCM but have diverse effects on the biomechanics of the myosin protein. We demonstrate that complex biomechanical effects of mutations associated with heart disease can be effectively studied and understood using a multi-scale experimental and computational modeling approach. This work confirmed an important role for disruption of the super-relaxed state for one particular HCM mutation, and our approach can be extended to aid in the development of new targeted therapies for patients with different mutations.
Effect of glycine as a complex agent on the surface and corrosion properties of Ni-P and Ni-P/Al2O3 electroless coating
Authors: Omar Refaie , Oraby Elsayed , Abdelrhman Yasser , Aboraia Mohammed 
Published: November 2020

Purpose
The ability to produce a uniform composition, high corrosion resistance with a hard coating layer during the electroless coating techniques are mainly based on the plating bath composition. The complexing agent is one of the most important components that control the coating layer properties. This paper aims to investigate the effect of the glycine as a complex agent on the surface and corrosion properties of Ni-P and Ni-P/Al2O3 electroless coating.

Design/methodology/approach
In this study, the effect of glycine as a complexing agent on the final surface and corrosion properties of the Ni-P and Ni-P/Al2O3 coatings has been investigated. The surface morphology and composition of the coated samples were investigated by scanning electron microscope (SEM) imaging and energy dispersive x-ray spectroscopy (EDS) analysis. Linear polarization scan and electrochemical impedance spectroscopy techniques were used to investigate the corrosion properties of the coating layer.

Findings
The results clarify that, glycine has a remarkable effect on the porosity content of Ni-P and Ni-P/Al2O3. It was found that increasing of glycine concentration results in higher porosity content in the coating layers. Also, the porosity in the coating layers minimizes the protectability of the coating against corrosion. The results also show that adding nano-alumina (Al2O3) to the coating path has improved the corrosion properties by decreasing the porosity in the coating layer. The scanning electron microscope (SEM) images showed that the concentration of glycine affects the content and distribution of alumina nanoparticles embedded in the coating layer. Also, it was observed that using a high concentration of glycine (0.4 M glycine), the alumina tends to agglomerate and the final alumina content in the coating was decreased.

Originality/value
The present study reveals that the quality of the final coating plays a major role in the corrosion performance of the steel substrate. The coating quality can by improve remarkably by optimization of the complexing agent used in the plating bath, to minimize the porosity involve in the coating layer.
Corrosion study on low molecular organic acids in the initial condensation zone of steam turbines
Authors: Tuo Weiling , Cao Shun'an , Zhong Jie 
Published: November 2020

Purpose
The purpose of this study was to investigate the corrosion of low molecular organic acids from water-steam cycles such as acetic acid and formic acid in mental parts of steam turbine initial condensation zone.

Design/methodology/approach
The corrosion behavior of gray cast iron in initial condensate containing different concentrations of acetic acid and formic acid was studied by weight loss test, scanning electron microscopy, energy dispersive spectroscopy and X-ray diffraction.

Findings
The results indicated that gray cast iron had a certain degree of corrosion in the simulated initial condensate containing acetic acid and formic acid, but the acid corrosion of gray cast iron was not only caused by low molecular organic acid but also affected by inorganic anions such as Cl−. When Cl− existed, after removing corrosion products, surface analysis results proved that the surface of gray cast iron was rough and uneven with many cracks, which was corrected more serious.

Originality/value
The corrosion behavior of thermal equipment by low molecular organic acids and inorganic anions in water-steam cycles was studied. The research results can provide theoretical guidelines for corrosion control of steam turbine in power plants.
Antecedents and postcedents of satisfaction in seller-business relationships: positive and negative alter egos
Authors: Høgevold Nils , Svensson Göran , Roberts-Lombard Mornay 
Published: November 2020

Purpose
This study explores a seller’s perspective in business relationships to validate whether the findings reported in previous studies based on buyer business relationships apply to seller business relationships. The purpose of this study is to test whether satisfaction functions as a connector between positive antecedents (trust and commitment) and negative postcedents (opportunism and conflict) in a business-to-business (B2B) relationship, based on a seller perspective.

Design/methodology/approach
A descriptive research design was applied and data was collected from Norwegian companies from the database of LinkedIn’s Sales Navigator. Respondents (Sales or Marketing Managers/Directors or Key Account Managers) were asked to identify one main business customer with whom they had interacted in the past year. A total of 213 responses could be used for data analysis. In addition, the measurement and structural models were assessed.

Findings
Trust was established as a positive alter ego of opportunism and opportunism as a negative alter ego of trust. The commitment was also determined to be a positive alter ego of conflict, with conflict being a negative alter ego of commitment. Furthermore, it was proven that alter egos are not opposites, but facets of antecedents and postcedents in relation to a connector, satisfaction.

Research limitations/implications
The tested model endorses the hypothesised relationships between trust, commitment, satisfaction, opportunism and conflict in Norwegian B2B relationships. Satisfaction is linked to its two antecedents and its outcomes and the hypothesised relationship between opportunism and conflict is also endorsed from a seller’s perspective in B2B relationships.

Practical implications
The findings can assist the B2B industry to understand how trust and commitment foster satisfaction, how satisfaction influences opportunism and conflict, and how opportunism relates to conflict in a seller-business relationship.

Originality/value
No previous study has focussed on relationship marketing in B2B relationships from a seller’s perspective to establish whether satisfaction functions as a connector between trust and commitment and opportunism and conflict.
State and self-regulation for better governance: an implication of collibration
Authors: Saleem Irfan , Lamarque Eric , Hasan Rashedul 
Published: November 2020

PurposeThe purpose of this study is to study the evolution of French corporate governance law in light of collibration approach and bring statistical evidence from French Companies Executive Compensation practices.Design/methodology/approachThe study has used mixed methods. In the first part, the authors analyzed the French laws in the light of collibration. In the second part of the study, the authors used unbalanced panel data to test the hypotheses related to executive remuneration based on the theoretical underpinning of collibration. Data for 173 firms listed in the Euronext Paris Index is collected from the Bloomberg database. Seemingly unrelated regression (SUR) analysis is performed to investigate the impact of collibration on the governance disclosure of French-listed firms.FindingsSUR results indicate that board size plays a significant role in the governance disclosure before collibration. However, the collibration model is found to be more effective in ensuring the desired level of governance disclosure. Under the collibration approach, executive remuneration, frequency of board meetings, executive directors in the compensation committee and independent directors play a significant role in governance disclosure. Board size, however, does not have a substantial impact on governance disclosure after the adoption of collibration mechanism.Research limitations/implicationsResults provided by this study can allow regulators to improve corporate disclosure regime in France, which could play a vital role in safeguarding the interest of stakeholder.Originality/valueThe authors study the impact of collibration on the extent of governance disclosure in the context of France. Empirical evidence on the implication of collibration as governance mechanisms to enhance stakeholder confidence is rare and allows this study to make a unique contribution to the governance literature.
Do mutual fund managers' possess style liquidity timing abilities?
Authors: Alam Mahfooz , Ansari Valeed Ahmad 
Published: November 2020

PurposeThis paper investigates the style timing and liquidity style timing vis-à-vis the market, size, value and momentum factors of the actively managed Indian equity mutual funds.Design/methodology/approachWe examine the style timing of the funds using the augmented Carhart four-factor model by incorporating timing measures (Treynor and Mazuy; Henriksson and Merton). Based on this, the study explores the four-factor liquidity and volatility style timing exhibited by fund managers. The sample is from April 2000 to March 2018 and spans the volatile 2008 subprime economic crises. The sample comprised 182 actively managed equity funds from various sizes and was considered to be a well-diversified sample.FindingsThe results of our study provide strong evidence of market liquidity timing in India. No other style timing skills are observed in our analysis. Our results also imply that the fund managers might misidentify size timing as market timing if integrated liquidity timing measures are not employed, leading to false conclusions.Research limitations/implicationsThe findings of our study imply that the fund managers might misidentify size timing as market timing if integrated liquidity timing measures are not employed, leading to false conclusions.Originality/valueThis study, to our knowledge, is the first attempt to investigate the portfolio-based style timing in the Indian context.
The nexus between records management and perceived corruption in sub-Saharan Africa
Authors: Adu Kofi Koranteng 
Published: November 2020

Purpose
This paper aims to chronicle perceived corruption cases emanating from poor records management in selected countries in sub-Saharan Africa by examining the nexus between records management and perceived corruption in Africa.

Design/methodology/approach
Using a content analysis approach, based on auditor’s report and detailed analysis of available literature, this study examines the nexus between records management and perceived corruption in Africa.

Findings
It observed that government agencies can easily be corrupted by inefficiencies in records management. However, a clear commitment to records management, underpinned by transparency and accountability, ensures that public office holders can be held accountable for their actions. Free and unhampered access to information promotes transparency in the administration of public funds and public participation.

Research limitations/implications
The study selected only 14 African countries for the study to establish the nexus between corruption and records management. Further studies are needed to cover all the countries in Africa.

Practical implications
The paper contributes to the ongoing debate that effective records management is crucially important in the prevention of corruption. It does this at a time when most African countries have made commitments towards the 17 goals of the 2030 Sustainable Development goals of the UN. The implementation of these goals can effectively be achieved in an environment where there is an effective records management system to ensure that public officers have access to information in the delivery of their duties.

Originality/value
The paper is written at a time when most African countries have made commitments towards the 17 goals of the 2030 Sustainable Development goals of the UN.
Money in politics: a recipe for corruption in Malaysia
Authors: Abas Azmi Khairul Saidah , Zainudin Rozaimah 
Published: November 2020

Purpose
This paper aims to investigate how money in politics contributes to corruption in Malaysia.

Design/methodology/approach
This study used in-depth semi-structured interviews to collect primary data. The interviews were conducted with two elite groups comprising seven politicians and seven corporate leaders. Data were then analysed using a thematic analysis approach.

Findings
The findings indicate how money in politics contributes to corruption in Malaysia. Various types of corruption in the country are identified, namely political donation, bribery and money politics. This study also provides evidence of the underlying factors driving money politics.

Practical implications
This paper offers valuable insights to policymakers and enforcement agencies for vigorous prosecution or appropriate sanction against the perpetrators. Especially on the weak regulation of political finance in Malaysia, this paper provides insights into how the weakness is used to manufacture corruption.

Originality/value
This paper provides evidence of how money politics cultivate corrupt activities, which are relatively sensitive and controversial by nature. The rarely obtained views from the elite groups provide a significant value to research.
Business financing and blockchain technology adoption in agroindustry
Authors: Rijanto Arief 
Published: November 2020

Purpose
This paper aims to explore patterns of business financing and adoption of blockchain technology in the agricultural industry. The adoption of blockchain technology in terms of recording, storing, validating and securing data can solve a variety of agricultural problems such as agricultural business financing. If the banking and insurance industries are connected in real-time to activity data in the agricultural industry, they can create better credit ratings and profile models. So, finally, all parties in the agricultural industry have a greater chance to get business financing from banks.

Design/methodology/approach
This paper uses a case study research approach with a framework of analysis of the theory of adoption of technology, organization and environment (TOE) and the theory of “mindfulness of adoption”. The case study method has advantages when verification is still questioned or the application of certain theories in practice as phenomena and contexts that occur in the field in accordance with the application of blockchain technology into a relatively new business, both technically and practically in the field.

Findings
The findings indicate that there are no barriers to the availability of blockchain technology for technology adoption. The characteristics of this technology are very suitable for solving financing and supply chain business problems in the agricultural industry. However, the adoption of blockchain technology in agriculture shows that there is complexity in the organizational context involving internal and external organizations. The number of organizations and small parties involved in the agricultural process challenges the adoption of blockchain technology as new technology. Then, the external environment of technology, especially government regulations in developing countries, is still an obstacle to the adoption of blockchain technology.

Research limitations/implications
This study faces several limitations, namely, the limited case of implementation of the blockchain technology due to the novelty of technology and government regulation. So that further research related to the adoption of blockchain technology needs to be done using field data such as surveys. Research related to the connectivity of the banking industry and other financial institutions also needs to be explored further, especially in creating a data-based credit risk model of the blockchain system.

Originality/value
On the practical side, case studies of technology adoption and its relationship with the financing of agricultural business are still little explored so this study contributes to exploring the application of blockchain technology in the agricultural industry. The adoption of blockchain technology has an impact not only on farmers but also on all parties involved in the supply chain including banks, insurance and other financial institutions. In addition, the distributed data exchange business model using blockchain technology is a new business model in the agriculture industry.
Designing creative teams from creative members: the role of reward interdependence and knowledge sharing
Authors: Zhang Yong , Li Guiquan , Wang Mingxuan 
Published: November 2020

PurposeThis paper aims to extend understanding of how team creative potential translates into team creativity. Drawing on social exchange theories, the authors propose that reward interdependence produce cooperative intra-team interactions, which in turn enables aggregate levels of individual member creativity to translate into team creativity. Further, the authors propose that reward interdependence enhances this link indirectly by motivating collective norms around knowledge sharing.Design/methodology/approachMulti-source and multi-wave data was collected from 94 R&D teams in two large medical firms. At Time 1, team members assessed the degree of reward interdependence and knowledge sharing characterizing their team; team leaders rated each member’s individual creativity. Unit leaders reported on the team’s overall creativity at Time 2 (three months after Time 1).FindingsThe results indicate that the effect of aggregate member creativity (AMC) on team creativity is moderated by reward interdependence in such a way that when reward interdependence is high, AMC has stronger positive effects on team creativity. Furthermore, knowledge sharing, as motivated by reward interdependence, mediates this moderating effect.Originality/valueBy integrating the team design and team creativity literatures, this paper advances an interactive model in which team creative composition combines with reward interdependence and knowledge sharing to help team creativity.
Land reclamation or Silk Road understanding Beijing’s initiatives in the South China Sea
Authors: Roy Nalanda 
Published: November 2020

Purpose
Southeast Asia’s position between the continents of Asia and Oceania gave the region a distinctive identity. Over the years, Southeast Asia has witnessed several important political changes and the emergence of new security threats. Historical mistrust, enduring territorial disputes and competition for maritime claims and resources have combined to weaken the regional security structure. The purpose of this paper is to explore whether China’s growing assertive position in the region bring some fresh air in the region following Beijing’s collaborative initiatives.

Design/methodology/approach
Seas are a central concern for Southeast Asian countries, so it is hardly surprising that the countries in the region are strongly nationalistic in asserting and protecting their claims. Maritime policy analyst, Mark Valencia, comments, “Indeed, when countries in Asia think maritime, they think first and foremost about boundary disputes, not the protection of the deteriorating marine environment or management of dwindling fisheries […] [it] is these perceptions that must change.” This paper will explore whether China’s growing assertive position in the name of diplomatic cooperation will mellow down and bring some fresh air into the South China Sea (SCS) region following Beijing’s One Belt One Road (OBOR) initiatives.

Findings
The world is still unsure when it comes to SCS! It often feels like “Pengci” or the art of staging drama to get the desired outcome? Beijing has to address the increasing global fears and uncertainty about her motives and talk more about its dracoplomacy. At one point, Beijing followed Xiaoping’s famous guideline: “hide our capacities and bide our time.” But now, things have changed. China is no longer actively avoiding international limelight. The motto has become “going international.” This change was not all talk either rather it was accompanied by significant, short-term action. Since becoming president, Xi has already visited more than 40 countries with his OBOR dream! It is important for Beijing to emphasize the purpose of her massive infrastructure push. That is, to achieve economic development, rather than to satisfy her growing political ambitions on the global stage. The creation of the Asian Infrastructure Investment Bank and other major geo-economic projects are signs that Beijing is using her coercive diplomacy in a subtler way. Therefore, this paper checks whether Beijing’s Silk Road spirit will be successful enough to maintain its agility and grace in the future.

Originality/value
This is an original piece of work, and it adds value to the special issue titled “China’s Rise and Power Shifts in Asia: Geopolitical, Socio-Economic and Historical Perspectives.”