bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intense remodeling of extracellular matrix within the varicose vein: the role of gelatinases and vascular endothelial growth factor
Authors: Horecka Anna , Hordyjewska Anna , Biernacka Jadwiga , Dąbrowski Wojciech , Zubilewicz Tomasz , Malec Agnieszka , Musik Irena , Kurzepa Jacek 
Published: October 2020

Abstract
Background
Increased blood pressure in the varicose veins (VV) can contribute to the overexpression of matrix metalloproteinases (MMPs), affecting the endothelium, smooth muscle, and extracellular matrix of the vein wall. Gelatinases (MMP-2 and MMP-9), hypoxia, and inflammation occurring in the VV wall contribute to the increased expression of vascular endothelial growth factor (VEGF).

Aims
Our objective was to analyze the concentration of gelatinases and VEGF in the great saphenous VV wall and plasma of patients.

Methods
In total, 65 patients (2nd degree according to clinical state classification, etiology, anatomy, and pathophysiology—CEAP classification) aged 22 to 70 were enrolled. Control veins (n = 10) were collected from the patients who underwent coronary artery bypass graft surgery. Control plasma (n = 20) was obtained from healthy individuals. Gelatinases and VEGF levels were measured with the usage of ELISA method.

Results
A significant increase in MMP-9 (11.2 vs. 9.98 ng/mg of protein) and VEGF (41.06 vs. 26 ng/g of protein) concentration in VV wall compared with control veins was observed. A positive correlation between VEGF versus MMP-2 (p = 0.03, r = 0.27) was found in the VV wall. However, no correlation was found between the concentration of VEGF and MMP-9 (p = 0.4, r = 0.11) in the VV wall. In addition, no statistical differences between MMP-9, MMP-2, and VEGF levels in plasma of VV patients compared with controls were noticed.

Conclusions
The results of the present study confirm that VV’s patients have altered expression of MMPs and VEGF. Overexpression of MMP-9 and VEGF in the VV wall may contribute to the spreading of inflammatory process and suggests the intense remodeling of extracellular tissue within the VV wall.
Diagnosis and Management of Lymphatic Disorders in Congenital Heart Disease
Authors: Kelly Benjamin , Mohanakumar Sheyanth , Hjortdal Vibeke Elisabeth 
Published: October 2020

Abstract
Purpose of Review
Lymphatic disorders have received an increasing amount of attention over the last decade. Sparked primarily by improved imaging modalities and the dawn of lymphatic interventions, understanding, diagnostics, and treatment of lymphatic complications have undergone considerable improvements. Thus, the current review aims to summarize understanding, diagnostics, and treatment of lymphatic complications in individuals with congenital heart disease.

Recent Findings
The altered hemodynamics of individuals with congenital heart disease has been found to profoundly affect morphology and function of the lymphatic system, rendering this population especially prone to the development of lymphatic complications such as chylous and serous effusions, protein-losing enteropathy and plastic bronchitis.

Summary
Although improved, a full understanding of the pathophysiology and targeted treatment for lymphatic complications is still wanting. Future research into pharmacological improvement of lymphatic function and continued implementation of lymphatic imaging and interventions may improve knowledge, treatment options, and outcome for affected individuals.
Cardiac Tumors: Diagnosis, Prognosis, and Treatment
Authors: Bussani Rossana , Castrichini Matteo , Restivo Luca , Fabris Enrico , Porcari Aldostefano , Ferro Federico , Pivetta Alberto , Korcova Renata , Cappelletto Chiara , Manca Paolo , Nuzzi Vincenzo , Bessi Riccardo , Pagura Linda , Massa Laura , Sinagra Gianfranco 
Published: October 2020

AbstractPurpose of ReviewCardiac masses frequently present significant diagnostic and therapeutic clinical challenges and encompass a broad set of lesions that can be either neoplastic or non-neoplastic. We sought to provide an overview of cardiac tumors using a cardiac chamber prevalence approach and providing epidemiology, imaging, histopathology, diagnostic workup, treatment, and prognoses of cardiac tumors.Recent FindingsCardiac tumors are rare but remain an important component of cardio-oncology practice. Over the past decade, the advances in imaging techniques have enabled a noninvasive diagnosis in many cases. Indeed, imaging modalities such as cardiac magnetic resonance, computed tomography, and positron emission tomography are important tools for diagnosing and characterizing the lesions. Although an epidemiological and multimodality imaging approach is useful, the definite diagnosis requires histologic examination in challenging scenarios, and histopathological characterization remains the diagnostic gold standard.SummaryA comprehensive clinical and multimodality imaging evaluation of cardiac tumors is fundamental to obtain a proper differential diagnosis, but histopathology is necessary to reach the final diagnosis and subsequent clinical management.
Clinical Implications of the Genetic Architecture of Dilated Cardiomyopathy
Authors: Wilsbacher Lisa D. 
Published: October 2020

Abstract
Purpose of Review
Dilated cardiomyopathy (DCM) frequently involves an underlying genetic etiology, but the clinical approach for genetic diagnosis and application of results in clinical practice can be complex.

Recent Findings
International sequence databases described the landscape of genetic variability across populations, which informed guidelines for the interpretation of DCM gene variants. New evidence indicates that loss-of-function mutations in filamin C (FLNC) contribute to DCM and portend high risk of ventricular arrhythmia.

Summary
A clinical framework aids in referring patients for DCM genetic testing and applying results to patient care. Results of genetic testing can change medical management, particularly in a subset of genes that increase risk for life-threatening ventricular arrhythmias, and can influence decisions for defibrillator therapy. Clinical screening and cascade genetic testing of family members should be diligently pursued to identify those at risk of developing DCM.
Experimental Characterization of Weightlessness During Glider Parabolic Flights
Authors: Caprace Denis-Gabriel , Gontier Camille , Iranmanesh Mohammad , Scoubeau Mehdi , Pletser Vladimir 
Published: October 2020

AbstractAccess to earthbound weightlessness is critical to many branches of applied sciences. Besides, several space systems require microgravity testing before their launch. Existing solutions (drop towers, parabolic flights, sounding rockets) offer variable durations and qualities of microgravity environment, but their cost and lead times make them unpractical for small actors such as universities or start-up companies. This leads to a growing interest for alternative microgravity platforms. Here, we study the use of gliders to perform parabolic flights at a lower cost, and we propose a systematic quantification of glider’s 0-g flight capabilities. Results of our flight test campaign show that gliders offer up to 5.5s of weightlessness, with excursions below 0.1g, and a satisfactory level of repeatability. Besides, the recordings do not suffer from the increased level of vibrations generated by piston engines, typical of light-aircraft-based alternatives. Operational considerations associated with glider parabolic flights are also discussed. Finally, we conclude that a microgravity platform based on gliders would be suitable especially for compact experiments and equipment in order to support accelerated design and development, or to produce preliminary experimental results.
Small-scale biogas facilities to enhance nutrient flows in rural Africa—relevance, acceptance, and implementation challenges in Ethiopia
Authors: Schoeber Mia , Rahmann Gerold , Freyer Bernhard 
Published: October 2020

AbstractOn smallholder farms in Ethiopia, livestock manure and organic residues are traditionally removed from fields for construction, feed, and fuel purposes, while the remainder stays in the field as feed or fertilizer. Burning and removing organic matter without replacing it leads to valuable losses of on-farm nutrients and soil carbon, which could otherwise be used to fertilize crops. Instead, resources need to be used efficiently by reducing and recycling organic residues and forming a closed production system. Competition between applications can be eliminated by bio-methanation using a biodigester. There, organic residues are transformed to biogas utilized for light and cooking and bioslurry, a nutritious organic fertilizer and source of organic matter. Through capturing nutrients in agricultural by-products, nutrients become available to the food system again. Literature review has been supplemented with empirical evidence from a study carried out in the central Ethiopian Highlands on 47 smallholder farms, to provide a baseline for further improvements on the management of biogas technology. The study identifies a series of inadequate handling practices and thus a significant potential to optimize the farming system around a biodigester. It is recommended to include forage legumes in the farm system to enhance on-farm available nutrients that can be recycled through a biodigester. It is further necessary to involve the private sector in biodigester programs, to improve local availability of materials, which are suitable to the local culture and traditions. Space for knowledge exchange between farmers and advisors like demonstration farms can further improve bioslurry management. Although challenges remain, the integration of a biodigester should be encouraged as it fulfills the production of energy and a nutritious and economic fertilizer without additional resources, resulting in a win-win situation for the farmer.
An experimental study on high-pressure water jets for paraffin scale removal in partially blocked production tubings
Authors: Yar’Adua Kabir H. , John Idoko J. , Abbas Abubakar J. , Lawal Kazeem A. , Kabir Aisha 
Published: October 2020

AbstractThe common practice of using chemicals and solid-entrained liquids to remove soft scales in production tubings is associated with a high risk of contaminating the environment and eroding pipe internal surfaces. Due to the suspended solids, the current practices are also characterized by high pumping costs and are more problematic to rotating parts of machinery than freshwater. As a cheap and less risky alternative to these corrosive chemicals and liquids, this paper investigates the feasibility of utilizing multiple high-pressure (HP) water jets for the same objective. A total of 54 experimental trials were conducted to study the effects of four factors on the efficiency of scale removal with multiple flat-fan nozzles at an orientation of 25°. The factors investigated are (1) number of nozzles; (2) spray injection pressure; (3) stand-off distance between the spray nozzle and target scale; and (4) condition of the production tubing: ambient and pressurized. Details of the experimental set-up, equipment and procedure are provided. The results of these controlled experiments show a positive correlation between descaling efficiency and spray injection pressure. The same set of experiments reveals a negative correlation between descaling efficiency and nozzle count, as well as between descaling efficiency and spray stand-off. However, for the scale samples and range of parameters investigated in this study, descaling efficiency did not exhibit significant dependency on the chamber conditions, i.e. ambient versus pressurized. The results of this study provide some insights into the feasibility of multiple HP water jets as a cleaner alternative to the use of corrosive chemicals and solid-entrained liquids to remove soft scales in production tubings in oil fields and other applications.
Formation evaluation and reservoir characteristics of the Messinian Abu Madi sandstones in Faraskour Gas Field, onshore Nile Delta, Egypt
Authors: Leila Mahmoud , Eslam Ali , El-Magd Asmaa Abu , Alwaan Lobna , Elgendy Ahmed 
Published: October 2020

AbstractThe Messinian Abu Madi Formation represents the most prospective reservoir target in the Nile Delta. Hydrocarbon exploration endeavors in Nile Delta over the last few decades highlighted some uncertainties related to the predictability and distribution of the Abu Madi best reservoir quality facies. Therefore, this study aims at delineating the factors controlling the petrophysical heterogeneity of the Abu Madi reservoir facies in Faraskour Field, northeastern onshore part of the Nile Delta. This work provides the very first investigation on the reservoir properties of Abu Madi succession outside the main canyon system. In the study area, Abu Madi reservoir is subdivided into two sandstone units (lower fluvial and upper estuarine). Compositionally, quartzose sandstones (quartz > 65%) are more common in the fluvial unit, whereas the estuarine sandstones are often argillaceous (clays > 15%) and glauconitic (glauconite > 10%). The sandstones were classified into four reservoir rock types (RRTI, RRTII, RRTIII, and RRTIV) having different petrophysical characteristics and fluid flow properties. RRTI hosts the quartzose sandstones characterized by mega pore spaces (R35 > 45 µm) and a very well-connected, isotropic pore system. On the other side, RRTIV constitutes the lowest reservoir quality argillaceous sandstones containing meso- and micro-sized pores (R35 > 5 µm) and a pore system dominated by dead ends. Irreducible water saturation increases steadily from RRTI (Swir ~ 5%) to RRTIV (Swir > 20%). Additionally, the gas–water two-phase co-flowing characteristics decrease significantly from RRTI to RRTIV facies. The gaseous hydrocarbons will be able to flow in RRTI facies even at water saturation values exceeding 90%. On the other side, the gas will not be able to displace water in RRTIV sandstones even at water saturation values as low as 40%. Similarly, the influence of confining pressure on porosity and permeability destruction significantly increases from RRTI to RRTIV. Accordingly, RRTI facies are the best reservoir targets and have high potentiality for primary porosity preservation.
Investigation of biomass components on the slow pyrolysis products yield using Aspen Plus for techno-economic analysis
Authors: Shahbaz Muhammad , AlNouss Ahmed , Parthasarathy Prakash , Abdelaal Ali H. , Mackey Hamish , McKay Gordon , Al-Ansari Tareq 
Published: October 2020

AbstractPrior information on the pyrolysis product behaviour of biomass components-cellulose, hemicellulose and lignin is critical in the selection of feedstock as components have a significant influence on the pyrolysis products yield. In this study, the effect of biomass components on the yield of slow pyrolysis products (char, bio-oil and syngas) is investigated using a validated ASPEN Plus® model. The model is simulated at a temperature of 450 °C, a heating rate of 10 °C/min and a solid residence time of 30 min. The results indicated that at the given conditions, lignin contributed 2.4 and 2.5 times more char yield than cellulose and hemicellulose. The hemicellulose contributed 1.33 times more syngas yield than lignin while the cellulose and hemicellulose contributed 8.67 times more bio-oil yield than lignin. Moreover, the cost involved in the production of char using lignin (110 $/ton) is significantly economical than using cellulose (285 $/ton) and hemicellulose (296 $/ton). The net CO2emission of lignin pyrolysis is 4.14 times lower than cellulose pyrolysis and 3.94 times lower than hemicellulose pyrolysis. It can be concluded that lignin pyrolysis is more advantageous than cellulose and hemicellulose pyrolysis. In the selection of feedstock for the slow pyrolysis, the feedstock with more lignin content is preferred.Graphical abstract
Implementation of a frailty screening programme and Geriatric Assessment Service in a nephrology centre: a quality improvement project
Authors: Nixon Andrew C. , Brown Julie , Brotherton Ailsa , Harrison Mark , Todd Judith , Brannigan Dawn , Ashcroft Quinta , So Beng , Pendleton Neil , Ebah Leonard , Mitra Sandip , Dhaygude Ajay P. , Brady Mark E. 
Published: October 2020

Abstract
Introduction
The aims of this quality improvement project were to: (1) proactively identify people living with frailty and CKD; (2) introduce a practical assessment, using the principles of the comprehensive geriatric assessment (CGA), for people living with frailty and chronic kidney disease (CKD) able to identify problems; and (3) introduce person-centred management plans for people living with frailty and CKD.

Methods
A frailty screening programme, using the Clinical Frailty Scale (CFS), was introduced in September 2018. A Geriatric Assessment (GA) was offered to patients with CFS ≥ 5 and non-dialysis- or dialysis-dependent CKD. Renal Frailty Multidisciplinary Team (MDT) meetings were established to discuss needs identified and implement a person-centred management plan.

Results
A total of 450 outpatients were screened using the CFS. One hundred and fifty patients (33%) were screened as frail. Each point increase in the CFS score was independently associated with a hospitalisation hazard ratio of 1.35 (95% CI 1.20–1.53) and a mortality hazard ratio of 2.15 (95% CI 1.63–2.85). Thirty-five patients received a GA and were discussed at a MDT meeting. Patients experienced a median of 5.0 (IQR 3.0) problems, with 34 (97%) patients experiencing at least three problems.

Conclusions
This quality improvement project details an approach to the implementation of a frailty screening programme and GA service within a nephrology centre. Patients living with frailty and CKD at risk of adverse outcomes can be identified using the CFS. Furthermore, a GA can be used to identify problems and implement a person-centred management plan that aims to improve outcomes for this vulnerable group of patients.
The Use of Science in Wildland Fire Management: a Review of Barriers and Facilitators
Authors: Hunter Molly E , Colavito Melanie M , Wright Vita 
Published: October 2020

Abstract
Purpose of Review
Science plays a critical role in natural resource management, and the use of science in decision-making is mandated by several policy initiatives. Other disciplines have documented the challenges associated with applying science to management and possible solutions to overcoming challenges, but the evaluation of science use in wildland fire management is relatively immature. In this paper, we reviewed the available literature that evaluates science use in wildland fire management and common barriers and facilitators to science use in decision-making.

Recent Findings
We developed a conceptual model that describes the possible uses of science in fire management (perception, planning, forecasting, implementation, assessment, communication, and policy), common barriers to science use (lack of science, uncertainty, funding/capacity, conflict), common facilitators to fire science use (collaboration, trust, boundary organizations, co-production), and factors that can act as facilitators or barriers to science use depending on their presence or absence (awareness, accessibility, relevance). In the context of our conceptual model, we reviewed 67 papers that examined fire science use between 1986 and 2019.

Summary
Most studies were conducted in the USA in the last 10 years and demonstrated that science is commonly used in fire management and that the maturation of organizations devoted to science translation and communication in the last 10 years has likely facilitated the application of fire science. The evaluation of fire science use, however, is still relatively immature, with studies needed on the use of fire science in countries outside the USA, the use of science in the management of wildfires, and in the crafting of policy related to wildland fire management.
An ILM-cosine transform-based improved approach to image encryption
Authors: Dua Mohit , Suthar Arun , Garg Arpit , Garg Vaibhav 
Published: October 2020

AbstractThe chaos-based cryptography techniques are used widely to protect digital information from intruders. The chaotic systems have some of special features that make them suitable for the purpose of encryption. These systems are highly unpredictable and are highly sensitive or responsive to the initial conditions, also known as butterfly effect. This sensitive dependence on initial conditions make these systems to exhibit an intricate dynamical behaviour. However, this dynamical behaviour is not much complex in simple one-dimensional chaotic maps. Hence, it becomes easy for an intruder to predict the contents of the message being sent. The proposed work in this paper introduces an improved method for encrypting images, which uses cosine transformation of 3-D Intertwining Logistic Map (ILM). The proposed approach has been split into three major parts. In the first part, Secure Hash Function-256 (SHA-256) is used with cosine transformed ILM (CT-ILM) to generate the chaotic sequence. This chaotic sequence is used by high-efficiency scrambling to reduce the correlations between the adjacent pixels of the image. In the second part, the image is rotated to move all the pixels away from their original position. In the third part, random order substitution is applied to change the value of image pixels. The effectiveness of the proposed method has been tested on a number of standard parameters such as correlation coefficient, Entropy and Unified average change in intensity. The proposed approach has also been tested for decryption parameters like mean square error and peak signal to noise ratio. It can easily be observed from the obtained results that the proposed method of image encryption is more secure and time efficient than some earlier proposed techniques. The approach works for both color and grey scale images.
Analysis of Functionally Graded Timoshenko Beams by Using Peridynamics
Authors: Yang Zhenghao , Oterkus Erkan , Oterkus Selda 
Published: October 2020

AbstractIn this study, a new peridynamic formulation is presented for functionally graded Timoshenko beams. The governing equations of the peridynamic formulation are obtained by utilising Euler-Lagrange equation and Taylor’s expansion. The proposed formulation is validated by considering a Timoshenko beam subjected to different boundary conditions including pinned support-roller support, clamped-roller support and clamped-free boundary conditions. Results from peridynamics are compared against finite element analysis results. A very good agreement is obtained for transverse displacements, rotations and axial displacements along the beam.