bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and cardiovascular risk factors of asymptomatic intracranial arterial stenosis: the Kongcun Town Study in Shandong, China
Authors: Sun Q. , Wang Q. , Wang X. , Ji X. , Sang S. , Shao S. , Zhao Y. , Xiang Y. , Xue Y. , Li J. , Wang G. , Lv M. , Xue F. , Qiu C. , Du Y. 
Published: December 2019

Background and purposeThis study was to investigate the prevalence and cardiovascular risk factors (CRFs) of asymptomatic intracranial atherosclerotic stenosis (aICAS) amongst middle‐aged and older adults living in rural communities in China.MethodsThis population‐based study included 2019 subjects (aged ≥40 years, 52.3% women) who were free of stroke and living in rural communities in China. From October 2017 to May 2018, data on demographics, CRFs and health conditions were collected through face‐to‐face interviews, physical examination and laboratory tests. Asymptomatic ICAS was detected through a two‐phase procedure: a screening phase with transcranial Doppler ultrasound, followed by a diagnostic phase with magnetic resonance angiography examination. Multivariable logistic regression models were used to analyse CRFs associated with aICAS.ResultsOf the 2019 participants, aICAS was detected in 153 persons. The overall prevalence of aICAS was 7.6%, and the prevalence of moderate‐to‐severe aICAS was 5.0%. The multi‐adjusted odds ratio (95% confidence interval) of aICAS associated with CRFs was 2.40 (1.56–3.69) for hypertension, 1.91 (1.32–2.76) for high hypersensitive C‐reactive protein, 1.68 (1.14–2.49) for diabetes and 1.61 (1.08–2.41) for overweight or obesity. When these four CRFs were aggregated, compared with participants without any of these factors, the multi‐adjusted odds ratios (95% confidence interval) of aICAS for persons concurrently having one, two and three or more of these factors were 1.14 (0.52–2.48), 2.91 (1.42–5.99) and 5.51 (2.64–11.50), respectively (P for linear trend <0.001).ConclusionsAsymptomatic ICAS is common amongst rural‐dwelling middle‐aged and older Chinese people. Hypertension, diabetes, overweight or obesity and high hypersensitive C‐reactive protein, especially when coexisting, are strongly associated with aICAS.
How do we overcome abrupt degradation of marine ecosystems and meet the challenge of heat waves and climate extremes?
Authors: Ainsworth Tracy D. , Hurd Catriona L. , Gates Ruth D. , Boyd Philip W. 
Published: December 2019

AbstractExtreme heat wave events are now causing ecosystem degradation across marine ecosystems. The consequences of this heat‐induced damage range from the rapid loss of habitat‐forming organisms, through to a reduction in the services that ecosystems support, and ultimately to impacts on human health and society. How we tackle the sudden emergence of ecosystem‐wide degradation has not yet been addressed in the context of marine heat waves. An examination of recent marine heat waves from around Australia points to the potential important role that respite or refuge from environmental extremes can play in enabling organismal survival. However, most ecological interventions are being devised with a target of mid to late‐century implementation, at which time many of the ecosystems, that the interventions are targeted towards, will have already undergone repeated and widespread heat wave induced degradation. Here, our assessment of the merits of proposed ecological interventions, across a spectrum of approaches, to counter marine environmental extremes, reveals a lack preparedness to counter the effects of extreme conditions on marine ecosystems. The ecological influence of these extremes are projected to continue to impact marine ecosystems in the coming years, long before these interventions can be developed. Our assessment reveals that approaches which are technologically ready and likely to be socially acceptable are locally deployable only, whereas those which are scalable—for example to features as large as major reef systems—are not close to being testable, and are unlikely to obtain social licence for deployment. Knowledge of the environmental timescales for survival of extremes, via respite or refuge, inferred from field observations will help test such intervention tools. The growing frequency of extreme events such as marine heat waves increases the urgency to consider mitigation and intervention tools that support organismal and ecosystem survival in the immediate future, while global climate mitigation and/or intervention are formulated.
Variation and evolution of C:N ratio among different organs enable plants to adapt to N‐limited environments
Authors: Zhang Jiahui , He Nianpeng , Liu Congcong , Xu Li , Chen Zhi , Li Ying , Wang Ruomeng , Yu Guirui , Sun Wei , Xiao Chunwang , Chen Han Y. H. , Reich Peter B. 
Published: December 2019

AbstractCarbon (C) and nitrogen (N) are the primary elements involved in the growth and development of plants. The C:N ratio is an indicator of nitrogen use efficiency (NUE) and an input parameter for some ecological and ecosystem models. However, knowledge remains limited about the convergent or divergent variation in the C:N ratios among different plant organs (e.g., leaf, branch, trunk, and root) and how evolution and environment affect the coefficient shifts. Using systematic measurements of the leaf–branch–trunk–root of 2,139 species from tropical to cold‐temperate forests, we comprehensively evaluated variation in C:N ratio in different organs in different taxa and forest types. The ratios showed convergence in the direction of change but divergence in the rate of change. Plants evolved toward lower C:N ratios in the leaf and branch, with N playing a more important role than C. The C:N ratio of plant organs (except for the leaf) was constrained by phylogeny, but not strongly. Both the change of C:N during evolution and its spatial variation (lower C:N ratio at midlatitudes) help develop the adaptive growth hypothesis. That is, plants with a higher C:N ratio promote NUE under strong N‐limited conditions to ensure survival priority, whereas plants with a lower C:N ratio under less N‐limited environments benefit growth priority. In nature, larger proportion of species with a high C:N ratio enabled communities to inhabit more N‐limited conditions. Our results provide new insights on the evolution and drivers of C:N ratio among different plant organs, as well as provide a quantitative basis to optimize land surface process models.
Factors influencing the success of knowledge management process in health care organisations: a literature review
Authors: Ayatollahi Haleh , Zeraatkar Kimia 
Published: December 2019

AbstractIntroductionKnowledge is a strategic resource in health care organisations and knowledge management (KM) is applied as an effective solution to overcome challenges, such as rising health care cost and increasing demands for improving quality of care. The aim of this review was to identify factors influencing the success of KM process in health care organisations of developed and developing countries.MethodsThis review was conducted in 2018. The sources used for searching relevant papers were PubMed, Scopus, Science Direct, Web of Knowledge, EMBASE and Google Scholar, and the time frame was between 1980 and 2017. The search terms were KM, health care services administration, health care organisation, hospital and clinic which were combined by using AND/OR Boolean operators.ResultsIn this review, 13 papers were included. The main success factors influencing KM implementation in health care organisations were organisational culture, information technology, organisational structure, and performance evaluation and measurement. In developed countries, organisational culture was the most frequent factor, while in developing countries, organisational culture and information technology were the most frequent ones.ConclusionIt seems that in developed and developing countries, organisational factors are the most frequent factors influencing successful KM in health care organisations.
Consumers' perception of and attitudes towards organic food in Galicia (Northern Spain)
Authors: Rodríguez‐Bermúdez Ruth , Miranda Marta , Orjales Inmaculada , Ginzo‐Villamayor María José , Al‐Soufi Wajih , López‐Alonso Marta 
Published: December 2019

AbstractAlthough the organic sector is still relatively small, the demand for organic food is increasing throughout the world. The characterization of consumers' perception of and attitudes towards organic food is important to enable the development of marketing policies aimed at attracting conventional consumers to the sector. Consumers' behaviour studies must be conducted specifically for different regions and countries as perceptions and attitudes vary across the world. In the present study, a questionnaire was designed for administration to consumers in Galicia (Northern Spain). The questionnaire was administered to 830 consumers in 200 establishments to obtain data about the consumers' perception of and attitudes towards organic food. The survey results showed that one‐third of responders consume organic food and that the typical profile of a consumer of organic food is a middle‐aged, medium‐high class, university‐educated female living in a large village, who shops in supermarkets and preferably consume vegetables, fruits and eggs. Most people who declared that they consume organic products confuse these with home and locally produced food, indicating the potential for growth of the organic sector by providing such consumers with appropriate information. Most consumers (including conventional consumers) have a good opinion of organic food and consider that it is better for health, is of better quality than conventional food and avoid pesticide residues. However, price continues to be a barrier to the consumption of organic produce. Most respondents stated that they would consume more organic food if the price was only between 10% and 30% higher than the conventional equivalent. Finally, organic consumers in Galicia showed positive attitudes towards using local breeds in organic agriculture, both for producing food and for ecotourism and educational activities. Such activities could contribute to conserving breed biodiversity and adding value to organic farming.
Distinct patterns of socio‐economic disparities in child‐to‐adolescent BMI trajectories across UK ethnic groups: A prospective longitudinal study
Authors: Lu Yi , Pearce Anna , Li Leah 
Published: December 2019

SummaryBackgroundIn many high‐income countries, body mass index (BMI)/obesity levels are inversely associated with socio‐economic position (SEP). Little is known whether socio‐economic patterns in BMI trajectories throughout childhood differ by ethnicity, especially in the United Kingdom.ObjectivesTo investigate socio‐economic disparities in child‐to‐adolescent BMI trajectories and risks of overweight and obesity during adolescence across ethnic groups.MethodsMixed‐effects fractional polynomial and multinomial regression models were applied to estimate socio‐economic differences in BMI trajectories (3‐14 years) and risk of overweight/obesity at 14 years, respectively, in the UK Millennium Cohort Study (n = 15 996). Analysis was stratified by ethnicity.ResultPoverty was associated with higher BMI in children of White and South Asian origins, with a small difference at 3 years, which widened with age to 0.75 kg/m2 (95% CI, 0.59‐0.91) and 0.77 kg/m2 (0.26‐1.27) at 14 years for the White and South Asian groups, respectively. There was a reverse income‐BMI association in children of Black (African‐Caribbean) origin with the poverty group having a lower BMI (−0.37 kg/m2 [−0.71 to ‐0.04] at 5 years; −0.95 kg/m2 [−1.79 to −0.11] at 14 years). These patterns also presented with maternal education as a SEP indicator and for obesity at 14 years.ConclusionsSocio‐economic advantage may not be universally associated with lower BMI, which should be considered when planning obesity interventions. The positive SEP‐BMI association in children of Black origin requires replication and merits further investigation into underpinning mechanisms.
Microvascular function in non‐dippers: Potential involvement of the salt sensitivity biomarker, marinobufagenin—The African‐PREDICT study
Authors: Strauss‐Kruger Michél , Smith Wayne , Wei Wen , Bagrov Alexei Y. , Fedorova Olga V. , Schutte Aletta E. 
Published: December 2019

AbstractSuppressed nighttime blood pressure dipping is associated with salt sensitivity and may increase the hemodynamic load on the microvasculature. The mechanism remains unknown whereby salt sensitivity may increase the cardiovascular risk of non‐dippers. Marinobufagenin, a novel steroidal biomarker, is associated with salt sensitivity and other cardiovascular risk factors independent of blood pressure. The authors investigated whether microvascular function in non‐dippers is associated with marinobufagenin. The authors included 220 dippers and 154 non‐dippers (aged 20‐30 years) from the African‐PREDICT study, with complete 24‐hour urinary marinobufagenin and sodium data. The authors determined dipping status using 24‐hour blood pressure monitoring and defined nighttime non‐dipping <10%. The authors measured microvascular reactivity as retinal artery dilation in response to light flicker provocation. Young healthy non‐dippers and dippers presented with similar peak retinal artery dilation, urinary sodium, and MBG excretion (P > .05). However, only in non‐dippers did peak retinal artery dilation relate negatively to marinobufagenin excretion after single (r = −0.20; P = .012), partial (r = −0.23; P = .004), and multivariate‐adjusted regression analyses (Adj. R2 = 0.34; β = −0.26; P < .001). The authors also noted a relationship between peak artery dilation and estimated salt intake (Adj. R2 = 0.30; β = −0.14; P = .051), but it was lost upon inclusion of marinobufagenin (Adj. R2 = 0.33; β = −0.015; P = .86). No relationship between microvascular reactivity and marinobufagenin was evident in dippers (P = .77). Marinobufagenin, representing salt sensitivity, may be involved in early microvascular functional changes in young non‐dippers and thus contributes to the development of hypertension and cardiovascular disease later in life.
Association between blood pressure and intracranial artery stenosis in a Chinese population
Authors: Song Xiaowei , Zhao Qiannan , Hua Yang , Wang Chunxiu , Liu Beibei , Guan Shaochen , Li Jun , Zhang Zhongying , Fang Xianghua , Wu Jian 
Published: December 2019

AbstractThe association between blood pressure and intracranial artery stenosis (ICAS) in different age groups has not been elucidated. Using data from the “China Hypertension Survey,” we conducted a cross‐sectional analysis of the association between blood pressure parameters and ICAS. In this study, participants older than 35 years were selected by stratified, multistage random sampling. Blood pressure was measured repeatedly at rest, and ICAS was assessed by transcranial doppler ultrasound. Binary logistic regression analysis was used to demonstrate the association between different blood pressure indicators and ICAS. Of the 3640 participants included (mean age 63 ± 13 years old, 57.8% female), systolic blood pressure (SBP) and pulse pressure (PP) were associated with ICAS in the general population; the multivariable adjusted odds ratio (OR) and corresponding 95% confidence interval (95% CI) of ICAS and multivessel stenosis were 1.32 (1.21, 1.45) and 1.29 (1.14, 1.46) per standard deviation (SD) increase in SBP and 1.44 (1.30, 1.59) and 1.52 (1.33, 1.74) for PP, respectively. Further analysis of this association in different age groups revealed inconsistent results between SBP and ICAS. Prehypertension (120 ≤ SBP < 140) could predict ICAS in the older group but not in the younger group, and the positive association between SBP and multivessel stenosis disappeared in the younger age group (P > .05 in all SBP subgroups). In conclusion, SBP and PP could not only identify ICAS in the middle‐aged and elderly population but could also provide some information about ICAS burden; however, these associations need to be interpreted differentially based on age subgroup.
Reimbursement of ambulatory blood pressure monitoring in the US commercial insurance marketplace
Authors: Dietrich Eric , Desai Raj , Garg Mahek , Park Haesuk , Smith Steven M. 
Published: December 2019

AbstractAmbulatory blood pressure monitoring (ABPM) is increasingly recommended for confirming hypertension diagnosis and ongoing hypertension monitoring. However, reimbursement in the United States is variable and low compared with other advanced health care systems. We examined the reimbursement of ABPM and factors associated with successful reimbursement. A retrospective analysis of IBM MarketScan® commercial claims database was conducted for patients ≥18 years with ≥1 ABPM claim from January 2012 to December 2016. The date of first the ABPM claim was used as the index date. Per‐beneficiary ABPM episode reimbursements were calculated by aggregating all ABPM‐related reimbursements within a 30‐day post‐index window, considered as an ABPM episode. Multivariable logistic regression was used to identify predictors of successful reimbursement. Of 20 875 beneficiaries with ABPM claims, 16 920 (81.0%) were reimbursed. The median reimbursement per beneficiary for an ABPM episode was $89 (Inter Quartile Range [IQR], $62, $132), driven primarily by reimbursement for the full procedure (median, $86; IQR, $66, $110). Comparing benefit plan types, consumer‐directed health plans provided the highest median reimbursement ($96; IQR, $61, $175). Successful reimbursement was associated with female patient sex (adjusted OR [aOR], 1.20; 95% CI, 1.11‐1.28), having a health maintenance organization (aOR 2.11; 95% CI, 1.82‐2.43) or point of service (aOR 2.08; 95% CI, 1.74‐2.49) as benefit plan types, claim filing by a specialist (aOR 1.26; 95% CI, 1.14‐1.40) and services provided at an outpatient hospital (aOR 1.17; 95% CI, 1.01‐1.35). Among commercially insured Americans, our data suggest significant variability in successful reimbursement. Accordingly, more uniform criteria for ABPM reimbursement may facilitate greater use of guideline‐recommended monitoring.
Inverted meiosis and the evolution of sex by loss of complementation
Authors: Archetti Marco 
Published: December 2019

AbstractInverted meiosis, in which sister chromatids segregate before homologous chromosomes, is a common aberration of conventional meiosis (in which sister chromatids segregate after homologous chromosomes) and is routinely observed in certain species. This raises an evolutionary mystery: what is the adaptive advantage of the more common, conventional order of segregation in meiosis? I use a population genetic model to show that asexual mutants arising from inverted meiosis are relatively immune from the deleterious effects of loss of complementation (heterozygosity), unlike the asexual mutants arising from conventional meiosis, in which loss of complementation can outweigh the two‐fold cost of meiosis. Hence, asexual reproduction can replace sexual reproduction with inverted meiosis, but not with conventional meiosis. The results are in line with analogous considerations on other alternative types of reproduction and support the idea that amphimixis is stable in spite of the two‐fold cost of meiosis because loss of complementation in mutant asexuals outweigh the two‐fold cost.
Epigenetic regulation in plant abiotic stress responses
Authors: Chang Ya‐Nan , Zhu Chen , Jiang Jing , Zhang Huiming , Zhu Jian‐Kang , Duan Cheng‐Guo 
Published: December 2019

AbstractIn eukaryotic cells, gene expression is greatly influenced by the dynamic chromatin environment. Epigenetic mechanisms, including covalent modifications to DNA and histone tails and the accessibility of chromatin, create various chromatin states for stress‐responsive gene expression that is important for adaptation to harsh environmental conditions. Recent studies have revealed that many epigenetic factors participate in abiotic stress responses, and various chromatin modifications are changed when plants are exposed to stressful environments. In this review, we summarize recent progress on the cross‐talk between abiotic stress response pathways and epigenetic regulatory pathways in plants. Our review focuses on epigenetic regulation of plant responses to extreme temperatures, drought, salinity, the stress hormone abscisic acid, nutrient limitations and ultraviolet stress, and on epigenetic mechanisms of stress memory.
Variability of piglet birth weights: A systematic review and meta‐analysis
Authors: Moreira Rennan Herculano Rufino , Pérez Palencia Jorge Yair , Moita Vitor Hugo Cardoso , Caputo Luciano Sales Santiago , Saraiva Alysson , Andretta Inês , Ferreira Rony Antônio , de Abreu Márvio Lobão Teixeira 
Published: December 2019

AbstractThe objective of the study was to evaluate the effects of litter size and supplementation of functional amino acids on the piglet birth weight variability through of a systematic review and meta‐analysis. PubMed, ISI Web of Science, Science Direct, Scopus and SciELO are the main used databases and were searched in January 2019 by using the following keywords and their combinations: within‐litter birth, weight variability, piglets, litter size, sow, amino acids, gestation, uniformity, CV and/or SD. Of the 64 pre‐selected articles, only articles presenting the coefficients of variation and/or standard deviations according to the litter size and different levels of amino acid supplementation in the sow diets during gestation were selected. The average birth weights of total and live piglets were 43% lower in litters from sows with high prolificacy than those from sows with low prolificacy. The weight variability was affected by high prolificacy sows, with increases of 4.04% and 4.54% in the coefficients of variation of total and born alive piglets respectively (p = .074; p = .009). The standard deviation increased by 180 g in born alive piglets to high prolificacy sows. The coefficients of variation of total and live piglets born from high prolificacy sows showed an increase of 4.04% and 4.54% respectively (p = .07; p < .05). There was a tendency for reduced weight variability with amino acids supplementation when considering the standard deviation of total born (p = .072). However, reproductive performance was not significantly influenced (p > .05). In conclusion, the average litter weight and the number of piglets born influence weight variability. Amino acids supplementation may reduce the birth weight variability between piglets. However, this effect depends on the amino acid used, the levels of supplementation and on other factors not completely addressed in this study. Thus, more research is necessary to fully elucidate this topic.