bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Six Plants of Apiaceae Family for Body Weight Management: A Review from the Perspective of Modern and Traditional Persian Medicine
Authors: Rameshk Maryam , Kalantari-Khandani Shahram 
Published: October 2020

Background::
Obesity is a common health concern among all populations and age groups worldwide and is a risk
factor that leads to a significant increase in mortality and cardiovascular diseases, type 2 diabetes, metabolic syndrome,
stroke, and cancer. Disappointing results and weight regain after stopping lifestyle modification or drug therapy indicate the
need for other methods of treatment to achieve better and longer effective results.

Objective:
In this study, the effect of the Apiaceae plants, including Carum carvi L., Bunium persicum Boiss., Cuminum
cyminum L., Anethum graveolens L., Foeniculum Vulgare Mill. and Trachyspermum ammi L., in the TPM to treat obesity,
were compared to modern database covering all in vivo and clinical trials on animal models or humans.

Method:
In TPM sources, we used the keywords, "Saman-e- Mufrat", "Hazāl", and "Mohazzel”. Each of the six plants were
searched in the electronic databases, including Pubmed, Scopus, and Embase from 1975 to 1/1/2020 using keywords, namely
"body mass", "body weight" and "obesity".

Results:
The results indicated that six plants had reducing effects on body weight, BMI, fat mass, and appetite in almost all
clinical studies on humans and some studies on animals.

Conclusion:
Since the TPM is a rich source of information about the medicinal properties and effects of medicinal plants,
investigating the therapeutic effects of plants from the perspective of TPM can represents the vision of a new horizon in the
treatment of many diseases.
Elachi Lemon (Citrus limon) Peel and Pulp: Antioxidant, Antimicrobial, Anticoagulant Activities, Bioactive Compounds, Minerals, and Heavy Metals
Authors: Khandker Shahad Saif , Kabir Alamgir , Hasan Md. Jahid , Ahmed Md. Shohael , Gan Siew Hua , Khalil Md. Ibrahim , Islam Md Asiful , Hossan Tareq , Kamal Mohammad Amjad 
Published: October 2020

Background:
According to a number of previous studies, citrus fruits are rich in phytochemicals,
minerals and bioactive compounds.

Objective:
The aim of this study was to investigate the antioxidant, antimicrobial and anticoagulant
activities, phytonutrients, bioactive compounds, mineral and heavy metals in the peel and pulp of
Elachi lemon (Citrus limon).

Methods:
Phytochemical screening was performed to estimate the total polyphenol, flavonoid, tannin,
reducing sugar, total protein and vitamin C contents. High performance liquid chromatography
was performed to determine the concentrations of phenolics and ascorbic acid. Antioxidant activities
were evaluated by measuring 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity,
reducing power assay and ferric reducing antioxidant power (FRAP) assay. Antibacterial activity
was evaluated by the disc diffusion method and minimum inhibitory concentration (MIC).
Besides estimating heavy metals and minerals, activated partial thromboplastin time (aPTT) and
prothrombin time (PT) were observed for detecting anticoagulant activity.

Results:
In the case of antioxidant and antimicrobial activities, the pulp was found to be richer.
Both the peel and pulp showed similar anticoagulant activities. Among the phytonutrients, protein
content was richer in the peel than in the pulp. Catechin, rutin, tannic, gallic and vanillic acids were
detected in the peel, whereas in pulp quercetin, tannic and gallic acids were found. Pb, Cr, Cd were
present in a negligible amount whereas, Co, Cu and Fe were high in both the peel and the pulp.

Conclusion:
This study exhibits that both the peel and the pulp of Citrus limon are a rich source of
antioxidant, antimicrobial, anticoagulant, minerals and various bioactive compounds with nutritional
values.
Lessons Learnt from a National Competition on Structural Optimization and Additive Manufacturing
Authors: Xiong Yulin , Bao Dingwen , Yan Xin , Xu Tao , Xie Yi Min 
Published: October 2020

Background::
As an advanced design technique, topology optimization has received
much attention over the past three decades. Topology optimization aims at finding an optimal material
distribution in order to maximize the structural performance while satisfying certain constraints.
It is a useful tool for the conceptional design. At the same time, additive manufacturing technologies
have provided unprecedented opportunities to fabricate intricate shapes generated by topology optimization.

Objective::
To design a highly efficient structure using topology optimization and to fabricate it using
additive manufacturing.

Method::
The bi-directional evolutionary structural optimization (BESO) technique provides the
conceptional design, and the topology-optimized result is post-processed to obtain smooth structural
boundaries.

Results::
We have achieved a highly efficient and elegant structural design which won the first prize
in a national competition in China on design optimization and additive manufacturing.

Conclusion::
In this paper, we present an effective topology optimization approach to maximize the
structural load-bearing capacity and establish a procedure to achieve efficient and elegant structural
designs.

:
In the loading test of the final competition, our design carried the highest loading and won the first
prize in the competition, which demonstrates the capability of BESO in engineering applications.
A CMT Device for Electrical Energy Meter Detection
Authors: Zeng Zhi , Zhou Yongfu 
Published: October 2020

Background:
Detection technology is a product development technique that serves as a basis for quality assurance. As electric energy meters (EEMs) are measurement instruments whose use is mandatory in several nations, their accuracy, which directly depends on their reliability and proper functioning, is paramount. In this study, to eliminate electromagnetic interference, a device is developed for testing a set of EEMs under a constant magnetic field interference. The detection device can simultaneously test 6 electric meters; moreover, in the future, it will be able to measure the influence of magnetic field strength on the measurement accuracy of EEMs, thereby improving the production efficiency of electric meter manufacturers.

Methods:
In this study, we first design a 3D model of the detection device for a single meter component; then, we establish a network, which includes a control system, and perform the planning of the path of a block that generates a constant magnetic field. Finally, we control the three-axis motion and rotation of the block using a PLC to implement detection for the five sides of the EEM.

Results & Discussion:
The proposed device can accurately determine whether an EEM can adequately function, within the error range prescribed by a national standard, under electromagnetic interference; this can enable reliable, automatic testing and fault detection for EEMs. Experiments show that our device can decrease the labor cost for EEM manufacturers.
COVID-19 Epigenetics and Implications for Public Health
Authors: Tunaligil Verda , Meral Gülsen , Kati Ahmet , Chattopadhyay Dhrubajyoti , Mandal Amit Kumar 
Published: October 2020

Background:
COVID-19 debilitated communities globally in varying complexities and capacities
in recent months.

Objective:
The epigenetic changes in the COVID-19 patients were discussed in this article to explore various
processes contributing to disease severity and elevation of risk due to infection.

Result & Conclusion:
The COVID-19 disease is observed to be the most severe in the 65 and-higher-age
group with pre-existing chronic conditions. This observational study is a nonexperimental empirical investigation
of the outcomes of COVID-19 in different patient groups. Results are promising for conducting clinical
trials with intervention groups. To ultimately succeed in disease prevention, researchers and clinicians must
integrate epigenetic mechanisms to generate valid prescriptions for global well-being.

Methods:
Percentages of hospitalization, with and without intensive care, in the presence of diseases with increased
ACE2 expression, were compared, based on the best available data. Further analysis compared two
different age groups, 19-64 and ≥65 years of age.
Comparison of Snail-1 and Estrogen Receptor Immunoexpression between Fibroadenomas and Phyllodes Tumors
Authors: Quzwain Fairuz 
Published: October 2020

Fibroadenomas (FA) and phyllodes tumors (PT) are fibroepithelial lesions in the breast, which until now the relationship between the pathogenesis of both have not been ascertained yet. Epithelial cells are thought to be involved in the regulation of changes in the stromal cells in the PT, so it can be estimated that this process is involved in epithelial-mesenchymal transition (EMT). This study aims to compare of snail family transcriptional repressor 1 (Snail-1) and estrogen receptor (ER) impression as EMT factors among tumor typeÂ (FA, benign PT, boderline PT and malignant PT). This study was an observational analysis with the cross-sectional method. After the histologic grade of the samples was reviewed, immunohistochemistry examination for ER and Snail-1 was performed. Statistical analysis for categorical data was tested by chi-square test. There were 66 samples, consists of 20 FA, 17 benign PT, 16 borderlines PT, and 13 malignant PT. A significant difference in the loss of ER expression in borderline and malignant PT was found compared to FA and benign PT. This is inversely proportional to the snail-1 expression, where the expression was high in borderline PT and malignant PT stromal cells. This could support the consideration of the pathomechanism regulation of epithelial-mesenchymal cell transition changes in FA with PT, where Snail-1 is one of the proteins in the regulation of the EMT and RE processes acting as an inhibiting factor in transcription factors in the mechanism of EMT occurrence.
ОРГАНІЗАЦІЯ ДИСТАНЦІЙНОГО НАВЧАЛЬНОГО ПРОЦЕСУ НА КАФЕДРІ ДЕРМАТОЛОГІЇ ТА ВЕНЕРОЛОГІЇ ІФНМУ В УМОВАХ ПАНДЕМІЇ 2019-NCOV
Authors: Волошинович М. С. , Сенчій В. М. , Александрук О. Д. , Ткач В. Є. , Гірник Г. Є. , Матковська Н. Р. 
Published: October 2020

Резюме. Спалах коронавірусної інфекції зруйнував нормальний ритм життя по всьому світу. Станом на сьогодні передбачити в повній мірі наслідки впливу пандемії на сектор навчання і в тому числі вищої освіти неможливо. У першу чергу це пов’язано з тим, що ситуація все ще розгортається, а безпосередні впливи нашаровуються на соціальні, психологічні, економічні та інші фактори суспільного середовища.
В умовах пандемії, що триває, набули нового значення і стали вирішенням більшості освітніх проблем механізми дистанційного навчання. Вони залишились єдиним доступним методом донесення знань в умовах збереження достатньої відстані поміж учасниками навчального процесу.
Для його організації варто покладатись на комплексні програмні рішення такі як платформа Teams. На кафедрі Дерматології та венерології дистанційна форма була застосована як для до дипломного, так і післядипломного навчання. Згідно з попередньо узгодженими графіками проводились щоденні відеоконсультації; для відповіді на дискутабельні запитання дисципліни, начитка лекційного матеріалу; завдання студенти отримували у вигляді тестів та клінічних задач.
Проте системі не вистачає можливостей до проведення опитувань під час лекцій з відображенням результатів голосування в реальному часі. Цю, необхідну функцію, а в умовах віддаленої освіти, і механізм для перевірки участі респондентів у засвоєнні матеріалу, можна реалізувати залученням сторонніх додатків, наприклад Mentimeter.
Застосування платформи сприяє збільшенню зацікавленості студентів навчальним матеріалом, забезпечує механізм перевірки активної участі респондентів у дискусії та отримання зворотного відклику. Проте важливим є не розгубити позитивні моменти старої моделі навчання, формуючи новий напрямок.
ЗМІНИ ФУНКЦІОНАЛЬНИХ ПАРАМЕТРІВ ЗОВНІШНЬОГО ДИХАННЯ У ЧОЛОВІКІВ З ОЖИРІННЯМ В ПРОЦЕСІ ФІЗИЧНОЇ ТЕРАПІЇ ЯК МАРКЕР ЕФЕКТИВНОСТІ ЕЛЕМЕНТІВ РЕСПІРАТОРНОЇ РЕАБІЛІТАЦІЇ
Authors: Аравіцька М. Г. 
Published: October 2020

Резюме. Цілі: визначення зміни параметрів функціонування дихальної системи у чоловіків з ожирінням під впливом засобів респіраторної реабілітації в рамках комплексної програми фізичної терапії.
Методи. Обстежено 116 чоловіків з аліментарно-конституціональним ожирінням І-ІІІ ступеня. За результатами визначення реабілітаційного альянсу їх було поділено на дві групи. Групу порівняння склали особи з низьким рівнем альянсу. Основну групу склали особи з високим рівнем альянсу, які проходили річну програму корекції із застосуванням заходів для підтримки альянсу, модифікації харчування, збільшення фізичної активності, лімфодренажу, психокорекції, елементів респіраторної терапії. Контрольну групу склав 31 чоловік з нормальною масою тіла. Досліджували суб’єктивний стан, інтенсивність задишки, параметри пульсоксиметрії, спірометрії.
Результати. У чоловіків з ожирінням виявлена дисфункціїя дихальної системи: суб'єктивні ознаки порушення дихальної функції, задишка, зменшення оксигенації артеріальної крові, зниження дихальних об'ємів. Їх зміст та ступінь вираженості були пропорційною важкості ожиріння. Застосування елементів респіраторної терапії в рамках програми комплексної фізичної терапії, спрямованої на зменшення маси тіла, дозволило нормалізувати досліджувані параметри функції дихальної системи. Низький рівень реабілітаційного альянсу призвів до незадовільного виконання наданих рекомендації та асоціювався із відсутністю реабілітаційного ефекту.
Висновки. Елементи респіраторної реабілітації патогенетично доцільно включати до схем відновлення стану здоров'я пацієнтів з ожирінням, особливо при високих його ступенях або супутніх захворюваннях.
Ключові слова: жирова тканина, бронхолегенева система, корекція.
Low Testosterone on Social Media: Application of Natural Language Processing to Understand Patients’ Perceptions of Hypogonadism and Its Treatment
Authors: Osadchiy Vadim , Jiang Tommy , Mills Jesse Nelson , Eleswarapu Sriram Venkata 
Published: October 2020

Background
Despite the results of the Testosterone Trials, physicians remain uncomfortable treating men with hypogonadism. Discouraged, men increasingly turn to social media to discuss medical concerns.

Objective
The goal of the research was to apply natural language processing (NLP) techniques to social media posts for identification of themes of discussion regarding low testosterone and testosterone replacement therapy (TRT) in order to inform how physicians may better evaluate and counsel patients.

Methods
We retrospectively extracted posts from the Reddit community r/Testosterone from December 2015 through May 2019. We applied an NLP technique called the meaning extraction method with principal component analysis (MEM/PCA) to computationally derive discussion themes. We then performed a prospective analysis of Twitter data (tweets) that contained the terms low testosterone, low T, and testosterone replacement from June through September 2019.

Results
A total of 199,335 Reddit posts and 6659 tweets were analyzed. MEM/PCA revealed dominant themes of discussion: symptoms of hypogonadism, seeing a doctor, results of laboratory tests, derogatory comments and insults, TRT medications, and cardiovascular risk. More than 25% of Reddit posts contained the term doctor, and more than 5% urologist.

Conclusions
This study represents the first NLP evaluation of the social media landscape surrounding hypogonadism and TRT. Although physicians traditionally limit their practices to within their clinic walls, the ubiquity of social media demands that physicians understand what patients discuss online. Physicians may do well to bring up online discussions during clinic consultations for low testosterone to pull back the curtain and dispel myths.
Manuel de Jesús Corral y Corral, La comunicación y sus entramados en América Latina. Cambiar nuestra casa, México, Plaza y Valdés/Universidad Autónoma de Nuevo León, 2004, 146 pp.
Authors: Gargallo Francesca 
Published: October 2020

Reseña del libro: Manuel de Jesús Corral y Corral, La comunicación y susentramados en América Latina. Cambiar nuestra casa,México, Plaza y Valdés/Universidad Autónoma de NuevoLeón, 2004, 146 pp.
María del Carmen Rovira Gaspar, Francisco de Vitoria. España y América. El poder y el hombre, México, H. Cámara de Diputados, LIX Legislatura/Miguel Ángel Porrúa, 2004, 307 pp. (Serie Conocer para Decidir). La
Authors: Magallón Anaya Mario 
Published: October 2020

Reseña del libro: María del Carmen Rovira Gaspar, Francisco de Vitoria.España y América. El poder y el hombre, México, H.Cámara de Diputados, LIX Legislatura/Miguel ÁngelPorrúa, 2004, 307 pp. (Serie Conocer para Decidir).La
Practice for the determination of convective coefficients
Authors: Durán Peralta Héctor Armando , Mayorga Betancourt Manuel Alejandro , Cordoba Castrillón Luis Fernando 
Published: October 2020

<br /><table class="t1" cellspacing="0" cellpadding="0"><tbody><tr><td class="td1" valign="top"><p class="p2"><span class="s1"> </span>El presente documento muestra cómo determinar el coeficiente de transferencia de calor en convección libre, utilizando datos de temperatura, leídos en forma de intervalo, alrededor del bulbo de un termómetro de vidrio. Para esto, se realizó el experimento de enfriamiento del bulbo de un termómetro y se registraron los datos del descenso del menisco del termómetro. Se construyeron dos modelos de transferencia de calor para el enfriamiento del bulbo, con su respectiva solución analítica. En el primer modelo, se consideró la temperatura del bulbo de mercurio igual a la temperatura de la envoltura de vidrio, mientras que en el segundo modelo no se consideró esta restricción. Con las soluciones analíticas de estos modelos y usando un método de mínimos cuadrados modificado para trabajar con datos leídos en forma de intervalo, se determinó el coeficiente experimental de transferencia de calor en forma de intervalo. Para validar ambos modelos, las temperaturas calculadas se graficaron y compararon con los datos experimentales. Los resultados muestran que el coeficiente de transferencia de calor calculado con el modelo sin restricciones es el que mejor representa los datos experimentales.<span class="Apple-converted-space"> </span></p></td></tr></tbody></table>
Phytochemical Screening and Evaluation of Antidiabetic Activity of the Marine Microalgae: Nannochloropsis Sp.
Authors: Deepa P. K  , Subramanian A  , Manjusha W.A.  
Published: October 2020

Diabetes mellitus is a metabolic disorder and is one of the major challenges on health of people all over the world. The phytochemicals of various marine algae are found to possess antioxidant, anti-inflammatory and anti-diabetic properties. Microalgae are photosynthetic organisms that produce oxygen and are capable of producing beneficial secondary metabolites. The bioactive metabolites like pigments, phenolics, amino acids, polyunsaturated fatty acids etc. produced by them have a positive effect on human health. In the present investigation, the marine microalgae Nannochloropsis sp. was screened for phytochemicals qualitatively and quantitatively. The evaluation of antidiabetic activity was determined against the enzymes such as alpha amylase and alpha glucosidase. The extracts were prepared in five different solvents such as petroleum ether, aqueous, isopropanol, methanol and ethyl acetate. The qualitative analysis for phytochemicals showed the presence of alkaloids, phenols, flavonoids, carbohydrates, proteins, cardiac glycosides, sterols, coumarin and tannins. The maximum total phenolic, flavonoid and sterol content was present in ethyl acetate extract of Nannochloropsis sp. and the values are found to be 42.17 ± 0.12mg GAE/g, 60.23 ± 0.09 mg QE/g, 55.34 ± 0.07 mg cholesterol/g of extract respectively. The ethyl acetate extract showed highest inhibitory effect of 78.52 ±0.56 % (IC50 121.96 µg/ml) on α-amylase and 80.42 ± 0.13 % (IC 50 178.53µg/ml) on α-glucosidase enzyme at a concentration of at 1mg/ml which implies the microalgae possess anti-diabetic property. The results indicate that the phytochemicals present in the microalgae contribute the antidiabetic activity. Hence Nannochloropsis sp. can be applied in pharmaceuticals for the development of antidiabetic drugs which have the benefits over side effects by the use of synthetic drugs.
Systemizing the Challenges of Auditing Blockchain-Based Assets
Authors: Pimentel Erica , Boulianne Emilio , Eskandari Shayan , Clark Jeremy 
Published: October 2020

ABSTRACT
Presently, auditing firms are hesitant to accept mandates from companies that hold a significant amount of cryptoassets, primarily because the blockchain sector introduces novel, technically sophisticated, and risky propositions that auditors are unequipped to handle. Abrupt recusals by auditors operating in this sector have led to several enterprises being placed on cease trade by securities regulators for failure to produce audited financial statements on time, thus impeding these companies from raising capital and bringing new investments to fund innovation in this space. Through an iterative process of interviews with senior accounting professionals, structured brainstorming among a multidisciplinary team of accountants and blockchain experts, and a focus group with experienced auditors, we critically analyze the purported roadblocks to auditing blockchain firms and map them to traditional auditing practices. We urge auditors to reconsider their resistance to the blockchain sector by demonstrating that providing an audit opinion is challenging but not insurmountable.
Cyber Supply Chain Risk Management: Toward an Understanding of the Antecedents to Demand for Assurance
Authors: Hampton Clark , Sutton Steve G. , Arnold Vicky , Khazanchi Deepak 
Published: October 2020

ABSTRACT
Recognizing the need for effective cyber risk management processes across the supply chain, the AICPA issued a new SOC in March 2020 for assuring cyber supply chain risk management (C-SCRM) processes. This study examines supply chain relationship factors and cyber risk issues to better understand the demand for C-SCRM assurance. Resource-Advantage Theory of Competition provides the conceptual foundation for assessing the dual drivers of relationship building and cyber risk management on demand for assurance. We use a field survey to collect data from 205 professionals enabling evaluation of the complex relationships in the theoretical model. Results support all hypotheses, provide satisfactory model fit, and support the underlying theory. Trust and cyber supply chain risk both positively influence demand for assurance over C-SCRM processes. This study expands the literature on cyber assurance by auditors and elaborates on overall supply chain processes that help drive value from auditors providing such assurance.