bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by sequential intermittent anti-PI3Kα/β/δ and anti-PD-1 treatment
Authors: Qi Zhi , Xu Zihan , Zhang Liuzhen , Zou Yongkang , Yan Wenyu , Li Cheng , Liu Ningshu , Wu Hong 
Published: October 2020

SummaryProstate cancers generally lack T cell infiltration and display resistance to immune checkpoint therapies (ICT). We found that intermittent but not daily dosing of PI3Kα/β/δ inhibitor BAY1082439 on aPten-null spontaneous prostate cancer model could overcome ICT resistance and unleash CD8+T cell-dependent anti-tumor immunityin vivo. Mechanistically, BAY1082439 convertsPten-null cancer cell-intrinsic immune-suppression to immune-stimulation by promoting IFNα/γ pathway activation, β2-microglubin expression and CXCL10/CCL5 secretion. Together with its preferential Treg inhibition activity, BAY1082439 promotes clonal expansion of tumor-associated CD8+T cells. Once primed, tumors remain as T cell-inflamed and become responsive to anti-PD-1 therapy. Our data suggest that intermittent PI3K inhibition can alleviatePten-null cancer cell-intrinsic immunosuppressive activity and turn “cold” tumors into T cell-inflamed ones, paving the way for successful ICT.SignificanceThe combination of ICT and targeted therapies holds great promises for broad and long-lasting therapeutic effects for cancers. However, combining ICT with anti-PI3K inhibitors have been difficult because the multifaceted effects of PI3K on both cancer cells and immune cells within the tumor microenvironment. Here we show a carefully designed anti-PI3K treatment, both in its specificity and dosing schedule, to inhibit cancer cell growth while promoting anti-tumor immunity, is critically important for successful ICT. Since the PI3K pathway is one of the most frequently altered signaling pathways in human cancers, our work may shed light on treating those cancers with PI3K activation and overcome resistance to ICT.HighlightsIntermittent PI3Kα/β/δ inhibitor BAY1082439 treatment overcomes ICT resistanceBAY1082439 turnsPten-null prostate cancer from “cold” to T cell-inflamedBAY1082439 inhibits cancer cell-intrinsic immunosuppressive activity and TregBAY1082439 promotes clonal expansion and immunity of tumor-associated CD8+T cells
Dynamic transformation of communal and exchange schemata in multicultural relationships
Authors: Liu Leigh Anne , Chiu Chi-Yue , Zhang Zhi-Xue 
Published: October 2020

PurposeThe purpose of this paper is to conceptually distinguish between communal and exchange relationship schemata and analyze their dynamic interactions and transformations in multicultural contexts.Design/methodology/approachDrawing on theories of social capital, social exchange, networks and relational models, the authors propose a framework to conceptualize how the communal and exchange relationship schemata can be transformed, integrated and multiplied under contextual influences, especially in culturally complex settings faced by multinational organizations.FindingsThe authors elucidate the dynamic processes of schemata interactions and transformations in relationship management at interpersonal, interorganizational and national levels in a variety of intercultural contexts, including interactions between monoculturals from different cultures and interplay of cultures within biculturals and among multiculturals. The authors explain how schemata integration and fusion can provide competitive advantages in navigating multicultural relationships.Research limitations/implicationsSystematic qualitative and quantitative studies are recommended to further test and refine the proposed ideas regarding the dynamic interactions and transformations of relationship schemata.Practical implicationsThis paper presents implications for individuals, country managers and leaders who need to initiate and maintain relationships with culturally different others. The authors highlight the desirability of being aware of one's own relational schema, understanding others' schema, bridging the two schemata as well as fostering integration and fusion of the schemata.Social implicationsThe 2020 global pandemic and various social upheavals around the world highlight the urgency of finding effective mental models to manage relationships. The inclusive and adaptive ways of thinking about relationships can potentially facilitate harmonious connections and conflict resolution.Originality/valueThe authors conceptually disentangle two established relationship schemata and offer a model of their dynamic synergetic transformations.
Ontology for preserving the knowledge base of traditional dances (OTD)
Authors: Kalita Deepjyoti , Deka Dipen 
Published: October 2020

PurposeSystematic organization of domain knowledge has many advantages in archiving, sharing and retrieval of information. Ontologies provide a cushion for such practices in the semantic Web environment. This study aims to develop an ontology that can preserve the knowledge base of traditional dance practices.Design/methodology/approachIt is hypothesized that an ontology-based approach for the chosen domain might boost collaborative research prospects in the domain. A systematic methodology was developed for modeling the ontology based on the analytico-synthetic rule of library classification. Protégé 5.2 was used as an editor for the ontology using the Web ontology language combined with description logic axioms. Ontology was later implemented in a local GraphDB repository to run queries over it.FindingsThe developed ontology on traditional dances (OTD) was tested using the dances of the Rabha tribes of North East India. Rabha tribes are from an indigenous mongoloid community and have a robust presence in Southeast Asian countries, such as Myanmar, Thailand, Bangladesh, Bhutan and Nepal. The result from HermiT reasoner found the presence of no logical inconsistency in the ontology, while the OOPS! pitfall checker tool reported no major internal inconsistency. The induced knowledge base of traditional dances of the Rabha’s in the developed OTD was further validated based on some competency questions.Research limitations/implicationsIn the growing trend of globalization, preservation of the cultural knowledge base of human societies is an important issue. Traditional dances reflect a strong base of the cultural heritage of human societies as they are closely related to the lifestyle, habitat, religious practices and festivals of a specific community.Originality/valueThe current study is exclusively designed, keeping in mind the variables of traditional dance domain based on a survey of the user- and domain-specific needs. The ontology finds probable uses in traditional knowledge information systems, lifestyle-based e-commerce sites and e-learning platforms.
Demographic determinants of charity donors and its implication for cashwaqfinstitutions in Malaysia
Authors: Khan Abidullah , Mohd. Shafiai Muhammad Hakimi , Shaique Muhammad , Khan Shabeer 
Published: October 2020

PurposeThe purpose of this study is to identify the demographic groups that can be targeted for donations by the cashwaqfinstitutions for their marketing campaigns in Malaysia.Design/methodology/approachThis paper uses a structured questionnaire to acquire the understanding of Malays about the existence of poverty in Malaysia and to identify the demographic groups that can be targeted for the marketing campaigns of cashwaqfinstitutions. The sample consisted of 430 Malays respondents residing in Selangor. The study used the methodology of Baron and Kenny for mediation analysis.FindingsThe finding indicates that Malays do hold sympathies towards the poor. Further investigation shows that high-income class and female are the two demographic groups that are more sympathetic towards the poor because of their strong belief in charity.Research limitations/implicationsThe data collection is limited to Selangor only. However, it provides enough information about the demographic groups which is worth exploring for the future researchers in order to come up with marketing strategies related to cash waqf collections.Practical implicationsOn the basis of findings, cash waqf institutions in Malaysia can come up with marketing strategies to attract high-income class and females as their potential donors.Originality/valueThe charity institution specifically cashwaqfinstitutions in Malaysia are struggling to identify the right target groups for their marketing campaigns. This study used attribution theory to identify the target groups which is overshadowed by the previous research studies in the context of Malaysia.
Similarities and differences in managing the Covid-19 crisis and climate change risk
Authors: Ruiu Maria Laura , Ragnedda Massimo , Ruiu Gabriele 
Published: October 2020

Purpose
This paper investigates both similarities and differences between two global threats represented by climate change (CC) and Covid-19 (CV). This will help understand the reasons behind the recognition of the CV as a pandemic that requires global efforts, whereas efforts to tackle climate change still lack such urgency. This paper aims to answer to the following questions: What are the elements that make CV restrictions acceptable by both the public and policymakers? and What are the elements that make CC restrictions not acceptable?

Design/methodology/approach
This paper analyses the situation reports released by the World Health Organisation between the 11th of March (declaration of pandemic) and the 22nd of April, and their associated documents such as the Strategic Preparedness and Response Plan (WHO), the Risk Communication and Community Engagement Action Plan (WHO) and its updated version (WHO) and the Handbook for public health capacity-building (WHO). The analysis ends one week after President Trump’s announcement to suspend US funding to WHO (Fedor and Manson, 2020) and his support to public demonstrations against restrictions.

Findings
The application of the second stage of the “Crisis and Emergency Risk Communication” model identifies five lessons that can be learned from this comparison. These relate to the necessity to simultaneously warn (about the severity of a threat) and reassure (by suggesting specific courses of action) the public; the need for multilevel collaboration that integrates collective and individual actions; the capacity to present cohesive messages to the public; the risk of politicisation and commodification of the issue that might undermine global efforts to tackle the threat; and the capacity to trigger individual responses through the promotion of self-efficacy.

Originality/value
This paper identifies both similarities and differences between CC and CV managements to understand why the two threats are perceived and tackled in different ways. The analysis of official documents released by both the World Health Organisation and the Intergovernmental Panel on Climate CV outbreak as a crisis, whereas climate change is still anchored to the status of a future-oriented risk.
A multilevel model of job insecurity and engagement
Authors: Pap Zselyke , Vîrgă Delia , Notelaers Guy , Maricuțoiu Laurențiu 
Published: October 2020

PurposeThe purpose of this current study was to investigate the moderating effect of autonomy (individual-level job resource) and social supportive climate (group-level job resource) on the negative relationship between job insecurity and work engagement.Design/methodology/approachCross-sectional data were gathered and analyzed using hierarchical linear modeling from 3,812 participants nested in 116 work units.FindingsA significant interaction between job insecurity and autonomy offered support for the buffering hypothesis of autonomy. Hypotheses regarding both the direct and the buffering effect of social supportive climate were also supported, suggesting that shared perceptions of a supportive environment can reduce the negative impact of job insecurity on work engagement.Practical implicationsFocus on unit climate can aid practitioners in designing interventions that take into account the effects, and make use of resources that are shared in the work-group.Originality/valueThis study extends the job demands-resources theory, showing that resources exist not only at the level of the individual but also a group-level phenomenon, and interact with demands across levels.
Predictors of information literacy self-efficacy among medical students: PLS-SEM analysis
Authors: Soroya Saira Hanif , Iqbal Malik Muhammad Yasir , Soroya Muhammad Shahid , Mahmood Khalid 
Published: October 2020

PurposeThe study was designed to examine the predictors of information literacy self-efficacy skills (IL skills) of medical students.Design/methodology/approachThe study was quantitative in nature and was carried out by using survey research method. Wong and Law Emotional Intelligence Scale (WLEIS) and Information Literacy Self-Efficacy Scale for medical students (ILSES-M) were used to collect the data. Data was collected randomly from 223 out of 526 undergraduate medical students on proportionally random basis according to the number of students available in each year. PLS-SEM analysis was run with the help of SmartPLS 3.2.FindingsThe findings of the study revealed that three subconstructs for emotional intelligence (EI), that is, self-emotions appraisal, others-emotion appraisal, use of emotions, had a statistically significant positive impact (p < 0.05) on information literacy (IL) self-efficacy of the medical students. The findings further confirm that English language proficiency and frequency of attended IL instruction sessions also have a significant positive impact on IL self-efficacy of medical students.Originality/valueThe exploration of EI in relation to IL is comparatively a novel area. The study observed the influence of EI level on IL self-efficacy of medical students. The study will be a significant contribution to the IL literature. The results may help the information professionals/librarians, particularly those who are engaged in teaching and designing IL programs.
The impact of founder’s regulatory focus on the process of firm birth and firm abandonment
Authors: Koumbarakis Paris , Bergmann Heiko , Volery Thierry 
Published: October 2020

PurposeThe purpose of this paper is to show how self-regulation influences the relationship between nascent entrepreneurial exploitation activities, firm birth and firm abandonment.Design/methodology/approachThis study draws from a unique longitudinal dataset of 181 nascent entrepreneurs from Switzerland who have been interviewed by phone in 2015 and 2016. It uses a moderated binary logistic regression to test the hypotheses.FindingsThis study provides evidence that discrepancies in promotion orientation can explain different ways exploitation can lead to an increased likelihood of firm birth and a decreased likelihood of firm abandonment while respectively increasing persistence. Findings suggest that this is attributed to the regulatory fit between a promotion orientation and exploitation activities.Research limitations/implicationsFor scholars, our findings provide insights into reasons for entrepreneurial persistence, as well as how firm birth can be achieved with different levels of exploitation activities.Practical implicationsThis study provides entrepreneurs with information on how to increase their persistence as well as the likelihood of firm birth while considering their regulatory focus.Originality/valueBased on regulatory focus theory, this paper highlights different paths to firm birth with varying quantity of exploitation activities. We contribute to a greater understanding of firm emergence by accounting for the impact of regulatory foci.
The interaction effect of transactional-transformational leadership on employee commitment in a developing country
Authors: Puni Albert , Hilton Sam Kris , Quao Benedicta 
Published: October 2020

Purpose
While substantial a number of research studies have examined the effect of leadership styles on work-related behaviour, the interaction effect of transactional-transformational leadership on work-related behaviour has been rarely investigated in a developing context. Thus, this study aims to examine the interaction effect of transactional-transformational leadership on employee commitment in Ghana.

Design/methodology/approach
The study used descriptive and cross-sectional survey designs. Cross-sectional data was obtained from 360 employees in the aviation industry of Ghana and analyzed using descriptive statistics, correlation and hierarchical regression techniques.

Findings
Transactional leadership style has a significant positive effect on employee commitment. However, when transformational leadership was added on transactional leadership base, there was no augmentation effect of transformational leadership style in predicting employee commitment. The results further indicate that there was a negative interaction effect of transactional and transformational leadership styles on employee commitment.

Practical implications
The findings imply that organizational leaders can improve employee commitment by purely resorting to transactional leadership behaviours. Leaders can also enhance employee commitment by augmenting transactional leadership behaviours on transformational leadership, as the reverse has no augmentation effect.

Originality/value
This study considerably complements existing leadership literature by establishing how a transformational leadership style can augment and/or interact with transaction leadership style to influence employee commitment in a developing country.
Attitude toward social media reviews and restaurant visit intention: a Bangladeshi perspective
Authors: Popy Nurun Naher , Bappy Tauhid Ahmed 
Published: October 2020

PurposeWhile the usage of social media reviews has become increasingly popular in recent years, few studies in this context of Bangladesh have investigated its impact on restaurant visit intention. Therefore, this study aims to explain the role of attitude toward social media reviews in customers' restaurant visit intention from the perspective of Bangladesh. In doing so, predictors of attitude toward social media reviews were also ascertained and their indirect effects on restaurant visit intention were investigated.Design/methodology/approachA survey questionnaire was administered to 300 university students. A six-factor based measurement model was proposed, and structural equation modeling (SEM) was used in testing the hypotheses represented by the model. Furthermore, a focus group discussion with 12 respondents was also held to assess how negative reviews on social media affect the customers' restaurant visit intention.FindingsThis study reveals that perceived usefulness, perceived ease of use, trustworthiness and information quality of social media reviews are positively related to attitude toward using positive social media reviews for choosing a restaurant. Furthermore, attitude toward positive social media reviews directly contributes to the intention to visit restaurants. Besides, attitude toward social media reviews fully mediates the relationship of perceived usefulness, perceived ease of use and trustworthiness with restaurant visit intention, whereas it partially mediates the relationship between information quality and restaurant visit intention. Besides, results from focus group discussion revealed that customers typically trust negative reviews which reduce their intent to visit restaurants.Research limitations/implicationsThe samples chosen for this study belong only to a particular stratum of the population (students from a specific institution/university). Hence, the outcomes should be generalized with caution.Practical implicationsThis study provides practical guidelines for the restaurant marketers to formulate improved strategic decisions by tracking the restaurant customers' attitudes, behavioral intentions, sentiments and share of voice on social media platforms. The results of this study will encourage the restaurant marketers to build sustainable relationships with influential food bloggers to spawn positive electronic word of mouth (e-WOM).Originality/valueThis is one of the first studies in Bangladesh that have covered up a timely and untouched research area, providing empirical evidence regarding the effects of attitude toward social media reviews on restaurant visit intent in the context of a South Asian country like Bangladesh.
Individual variation in seasonal acclimation by sympatric amphibians: A climate change perspective
Authors: Winterová Barbora , Gvoždík Lumír 
Published: October 2020

Abstract

Many ectotherms modify their phenotype seasonally as a response to variation in abiotic factors. Given the potential of seasonal acclimation to reduce the impact of climate change on the dynamics of ectotherm populations, the adaptive evolution of this reversible plasticity has received much attention. Nevertheless, the key assumption of selection on the magnitude of seasonal acclimation, consistent among‐individual variation (repeatability), remains unexplored.

We studied the short‐ (across body temperatures) and long‐term (over two consecutive years) repeatability of seasonal acclimation on standard metabolic rate (SMR) and spontaneous locomotor activity (SLA) in two sympatric newt taxa, Ichthyosaura alpestris and Lissotriton vulgaris. We exposed the newts to various fluctuating thermal regimes over spring and summer and measured SMR and SLA at three body temperatures in each individual over two consecutive years. We quantified seasonal acclimation as difference between summer and spring trait values.

We show that individuals of both species vary substantially in their seasonal acclimation responses. Body temperature affected the population means of seasonal acclimation in a quadratic I. alpestris or linear L. vulgaris fashion. Both short‐ and long‐term repeatability of SMR and SLA seasonal acclimation were poor and both species varied in the amount of total variation in the plastic response. Seasonal shifts in environmental temperatures showed high variation between years, but with no apparent trend attributable to local climate change.

Our results demonstrate that seasonal SMR and SLA acclimation prevents the establishment of a consistent relationship between individual trait values and environmental gradients, which may limit the adaptive evolution of this plastic response. Disparate thermal dependence patterns and the amount of total variation in seasonal acclimation suggest a species‐specific ability for coping with stochasticity of seasonal variation in the thermal environment.

To sum up, information on individual variation and population means measured across ecologically realistic body temperatures is necessary to fully understand the occurrence of seasonal acclimation across taxa and its role in the adaptive capacity to climate change.

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