bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma Thymidine Kinase Activity as a Biomarker in Patients with Luminal Metastatic Breast Cancer Treated with Palbociclib within the TREnd Trial
Authors: McCartney Amelia , Bonechi Martina , De Luca Francesca , Biagioni Chiara , Curigliano Giuseppe , Moretti Erica , Minisini Alessandro Marco , Bergqvist Mattias , Benelli Matteo , Migliaccio Ilenia , Galardi Francesca , Risi Emanuela , De Santo Irene , Romagnoli Dario , Biganzoli Laura , Di Leo Angelo , Malorni Luca 
Published: January 2020

Abstract

Purpose:
Thymidine kinase 1 (TK1) is downstream to the CDK4/6 pathway, and TK activity (TKa) measured in blood is a dynamic marker of outcome in patients with advanced breast cancer (ABC). This study explores TK1 as a biomarker of palbociclib response, both in vitro and in patients with ABC.

Experimental Design:
Modulation of TK1 levels and activity by palbociclib were studied in seven estrogen receptor–positive breast cancer cell lines: sensitive (PDS) and with palbociclib acquired resistance (PDR). TKa was assayed in plasma obtained at baseline (T0), after one cycle (T1), and at disease progression on palbociclib (T2) in patients enrolled in the “To Reverse ENDocrine Resistance” (TREnd) trial (n = 46).

Results:
Among E2F-dependent genes, TK1 was significantly downregulated after short-term palbociclib. Early TKa reduction by palbociclib occurred in PDS but not in PDR cells. In patients, median TKa (mTKa) at T0 was 75 DiviTum units per liter (Du/L), with baseline TKa not proving prognostic. At T1, mTKa decreased to 35 Du/L, with a minority of patients (n = 8) showing an increase—correlating with a worse outcome than those with decreased/stable TKa (n = 33; mPFS 3.0 vs 9.0 months; P = 0.002). At T2, mTKa was 251 Du/L; patients with TKa above the median had worse outcomes on post-study treatment compared with those with lower TKa (2.9 vs 8.7 months; P = 0.05).

Conclusions:
TK is a dynamic marker of resistance to palbociclib which may lead to early identification of patients in whom treatment escalation may be feasible. In addition, TKa may stratify prognosis in patients with acquired resistance to palbociclib.
Cardiac Intervention Improves Heart Disease and Clinical Outcomes in Patients With Muscular Dystrophy in a Multidisciplinary Care Setting
Authors: Nikhanj Anish , Yogasundaram Haran , Miskew Nichols Bailey , Richman‐Eisenstat Janice , Phan Cecile , Bakal Jeffrey A. , Siddiqi Zaeem A. , Oudit Gavin Y. 
Published: January 2020

Background

Patients with muscular dystrophy (
MD
) represent a vulnerable patient population with no clearly defined care model in modern‐day clinical practice to manage a high burden of heart disease and comorbidities. We demonstrate the effectiveness of cardiac interventions, namely the initiation and optimization of medical and device therapies, as part of a multidisciplinary care approach to improve clinical outcomes in patients with
MD
.

Methods and Results

We conducted a prospective cohort study at the Neuromuscular Multidisciplinary clinic following patients with dystrophinopathies, limb‐girdle
MD
, type 1 myotonic dystrophy, and facioscapulohumeral
MD
. A negative control group classified as non‐
MD
myopathies without heart disease, was also tracked. Our cohort of 185 patients (median age: 42 years; 79 [42.7%] women), included 145 patients with
MD
. Cardiomyopathy was present in 65.6% of the patients with dystrophinopathies (21 of 32) and 27.3% of the patients with limb‐girdle
MD
(9 of 33). Conduction abnormalities were common in type 1 myotonic dystrophy (33.3% [20/60] patients). Cardiac intervention reversed systolic dysfunction, with left ventricular ejection fraction improving from 43% to 50.0% over a 3‐year period. A sustained reduction in healthcare utilization was also observed. The number of outpatient clinic visits decreased from 3.0 to 1.5 visits per year, the duration of hospitalizations was reduced from 14.2 to 0.9 days per year, and the number of cardiac‐related hospitalizations decreased from 0.4 to 0.1 hospitalizations per year associated with low mortality.

Conclusions

Our study demonstrates that cardiac intervention as part of a comprehensive multidisciplinary care approach to treating patients with
MD
leads to a sustained improvement in clinical outcomes.
Madame Desoye, “First Woman Importer” of Japanese Art in Nineteenth-Century Paris
Authors: Emery Elizabeth 
Published: January 2020

Abstract
The shop run by Madame Desoye at 220, rue de Rivoli in Paris is legendary in Japonisme studies thanks to the writings of Edmond de Goncourt and Philippe Burty, yet the identity of the woman hidden behind this married name, like the extent of her participation in Japoniste activities, has long remained a mystery. The present article draws upon new archival research to provide information about the life of Louise Mélina Desoye, née Chopin (1836-1909) and her important contributions to the first wave of French Japonisme.
The Painters of the Blaue Reiter and Japan
Authors: Delank Claudia 
Published: January 2020

Abstract
Japonisme, like today’s Japanese pop culture, is a transcultural phenomenon. In the ‘classical phase of Japonisme’ individual artists were influenced by Japanese art (especially by ukiyo-e woodblock prints) and transcended thematic and compositional adaption: the confrontation with Japanese art sparked a creative process and led to new developments in art. Japonisme became not only an important medium in the development of modern western art, but also attested a cultural transcendence.
A minority language in the globalizing world: The Buryat language on the Internet
Authors: Zhanaev Ayur , Połeć Wojciech 
Published: January 2020

A minority language in the globalizing world: The Buryat language on the InternetThe situation of languages on the Internet seems to reproduce their situation in offline reality: dominant languages with a large number of users and support from state and society are more widespread. This does not mean, however, that minority languages are not present in the Internet. In this paper, using the example of the Buryat language, we are trying to show that websites or webpages in minority languages are created not only for instrumental but also autotelic reasons. Buryats make efforts to preserve their own language and culture; they are driven by a desire to emphasize their activity or by comparison with other nations which have websites in their own languages. An important issue in our discussion is the relationship between efforts aimed at the preservation and development of ethnic language in spoken and written form and the development of web content in that language. We thus show the relationship between “on-line” and “off-line” problems faced by Buryats today. Język mniejszości w globalizującym się świecie: język buriacki w InternecieSytuacja języków w Internecie zdaje się reprodukować ich sytuację w rzeczywistym świecie: języki dominujące, z dużą liczbą użytkowników, mogące liczyć na pomoc państw są bardziej rozprzestrzenione. Nie znaczy to jednak, że języki mniejszości nie są w Internecie obecne. W niniejszym opracowaniu, posługując się przykładem języka buriackiego, staramy się pokazać, że witryny czy też strony internetowe w językach mniejszościowych są tworzone nie tylko w celach instrumentalnych, ale także autotelicznych. Buriaci podejmują wysiłki, by chronić swój język i swoją kulturę, kierowani są chęcią podkreślenia swojej aktywności, porównaniami z innymi narodami, które mają witryny internetowe w swoich własnych językach. Ważną częścią naszej analizy są związki między wysiłkami mającymi na celu zachowanie i rozwój języka tnicznego w formie mówionej i pisanej a rozwojem treści internetowych w tym języku. Pokazujemy więc związki między problemami on-line i off-line, z jakimi borykają się współcześnie Buriaci.
Rozwój i stan krajobrazu językowego – przypadek języka wilamowskiego
Authors: Majerska-Sznajder Justyna 
Published: January 2020

The development and current state of the linguistic landscape – the case of the Wymysorys languageWymysorys is a micro-language with Germanic roots spoken by the residents of Wilamowice, a small Silesian town located between Oświęcim and Bielsko-Biała, where it was brought by settlers from Western Europe in the thirteenth century. It has been the subject of scholarly interest among specialists in a number of fields, not only linguistics and ethnology, since the early twentieth century. Following a ban issued by local authorities in 1945, the use of Wymysorys was prohibited and public manifestations of local culture were severely punished. This policy resulted in a drastic decline of the number of its users. The recent interest of researchers is focused not only on the documentation of Wymysorys or its sociolinguistic situation in the past and today, but also on the effects of its revitalization in the last decade. Despite the lack of institutional support, the users’ community has been engaged in grass-roots initiatives leading to the emergence of Wymysorys in the cultural landscape. Recent activity of its users indicates that the language has already spread beyond the circles of local activists and, after years of persecution, functions again in society, evolving and taking new forms. Rozwój i stan krajobrazu językowego – przypadek języka wilamowskiegoJęzyk wilamowski, którym posługują się mieszkańcy Wilamowic (wym. Wymysoü), od początku XX wieku interesuje naukowców wielu dziedzin – nie tylko lingwistów i etnologów. Został on przywieziony przez osadników z Europy Zachodniej w XIII wieku na teren obecnych Wilamowic – małego miasteczka na Śląsku leżącego między Oświęcimiem a Bielskiem-Białą. Na skutek zakazu wydanego przez władze lokalne w 1945 roku używanie wilamowskiego było zabronione, a wszelkie publiczne przejawy odmiennej kultury ostro karane, w związku z czym liczba użytkowników wilamowskiego zaczęła drastycznie maleć. Zainteresowanie badaczy ostatnimi czasy wzbudza nie tylko kwestia dokumentacji tego mikrojęzyka o germańskich korzeniach czy stan etnolingwistyczny. Obserwacji podlegają również obecne efekty zaaplikowanych w ostatniej dekadzie procesów rewitalizacji językowej i zmiany lokalnej, a także państwowej polityki językowej. Mimo braku instytucjonalnego wsparcia, społeczeństwo użytkowników oddolnie podejmuje inicjatywy, których efektem jest między innymi pojawianie się wilamowskiego w krajobrazie kulturowym. Ostatnie działania użytkowników języka świadczą o tym, że opuścił już kręgi lokalnych aktywistów i ponownie, po latach zakazu, funkcjonuje samodzielnie w społeczeństwie, ewoluując i przybierając nowe formy.
Health Care Resource Utilization in Commercially Insured Patients Undergoing Anterior Cervical Discectomy and Fusion for Degenerative Cervical Pathology
Authors: Marrache Majd , Harris Andrew B. , Puvanesarajah Varun , Raad Micheal , Hassanzadeh Hamid , Riley Lee H. , Skolasky Richard L. , Bicket Mark , Jain Amit 
Published: January 2020

Study Design: Retrospective review of an administrative database. Objectives: The aim of our study was to investigate the distribution of spending for the entire episode of care among nonelderly, commercially insured patients undergoing elective, inpatient anterior cervical discectomy and fusion (ACDF) surgeries for degenerative cervical pathology. Methods: Using a private insurance claims database, we identified patients who underwent single-level, inpatient ACDF for degenerative spinal disease. Patients were selected using a combination of Current Procedural Terminology (CPT) and International Classification of Diseases (ICD) codes. Entire episode of care was defined as 6-months before (preoperative) to 6 months after (postoperative) the surgical admission. Results: In our cohort containing 33 209 patients, perioperative median spending per patient (MSPP) within the year encompassing surgery totaled $37 020 (interquartile range [IQR] $28 363-$49 206), with preoperative, surgical admission, and postoperative spending accounting for 9.8%, 80.7%, and 9.5% of total spending, respectively. Preoperatively, MSPP was $3109 (IQR $1806-$5215), 48% of patients underwent physical therapy, and 31% underwent injections in the 6 months period prior to surgery. Postoperatively, MSPP was $1416 (IQR $398-$3962), and unplanned hospital readmission (6% incidence) accounted for 33% of the overall postoperative spending. Discharge to a nonhome discharge disposition was associated with higher postoperative spending ($14 216) compared with patients discharged home ($1468) and home with home care ($2903), P < .001. Conclusion: Understanding the elements and distribution of perioperative spending for the episode of care in patients undergoing ACDF surgery for degenerative conditions is important for health care planning and resource allocation.
High-parametric evaluation of human invariant natural killer T cells to delineate heterogeneity in allo- and autoimmunity
Authors: Erkers Tom , Xie Bryan J. , Kenyon Laura J. , Smith Brian , Rieck Mary , Jensen Kent P. , Ji Xuhuai , Basina Marina , Strober Samuel , Negrin Robert S. , Maecker Holden T. , Meyer Everett H. 
Published: January 2020

Abstract
Human invariant natural killer T (iNKT) cells are a rare innate-like lymphocyte population that recognizes glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogeneous and are capable of enacting diverse functions, and the composition of iNKT cell subsets can alter disease outcomes. In contrast, far less is known about how heterogeneity in human iNKT cells relates to disease. To address this, we used a high-dimensional, data-driven approach to devise a framework for parsing human iNKT heterogeneity. Our data revealed novel and previously described iNKT cell phenotypes with distinct functions. In particular, we found 2 phenotypes of interest: (1) a population with T helper 1 function that was increased with iNKT activation characterized by HLA-II+CD161– expression, and (2) a population with enhanced cytotoxic function characterized by CD4–CD94+ expression. These populations correlate with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and with new onset type 1 diabetes, respectively. Our study identifies human iNKT cell phenotypes associated with human disease that could aid in the development of biomarkers or therapeutics targeting iNKT cells.
Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML
Authors: DiNardo C. D. , Tiong I. S. , Quaglieri A. , MacRaild S. , Loghavi S. , Brown F. C. , Thijssen R. , Pomilio G. , Ivey A. , Salmon J. M. , Glytsou C. , Fleming S. A. , Zhang Q. , Ma H. , Patel K. P. , Kornblau S. M. , Xu Z. , Chua C. C. , Chen Xufeng , Blombery P. , Flensburg C. , Cummings N. , Aifantis I. , Kantarjian H. , Huang D. C. S. , Roberts A. W. , Majewski I. J. , Konopleva M. , Wei A. H. 
Published: January 2020

Abstract
The BCL-2 inhibitor venetoclax combined with hypomethylating agents or low-dose cytarabine represents an important new therapy for older or unfit patients with acute myeloid leukemia (AML). We analyzed 81 patients receiving these venetoclax-based combinations to identify molecular correlates of durable remission, response followed by relapse (adaptive resistance), or refractory disease (primary resistance). High response rates and durable remissions were typically associated with NPM1 or IDH2 mutations, with prolonged molecular remissions prevalent for NPM1 mutations. Primary and adaptive resistance to venetoclax-based combinations was most commonly characterized by acquisition or enrichment of clones activating signaling pathways such as FLT3 or RAS or biallelically perturbing TP53. Single-cell studies highlighted the polyclonal nature of intratumoral resistance mechanisms in some cases. Among cases that were primary refractory, we identified heterogeneous and sometimes divergent interval changes in leukemic clones within a single cycle of therapy, highlighting the dynamic and rapid occurrence of therapeutic selection in AML. In functional studies, FLT3 internal tandem duplication gain or TP53 loss conferred cross-resistance to both venetoclax and cytotoxic-based therapies. Collectively, we highlight molecular determinants of outcome with clinical relevance to patients with AML receiving venetoclax-based combination therapies.
Intraspecific diversification of the crop wild relative Brassica cretica Lam. using demographic model selection
Authors: Kioukis Antonios , Michalopoulou Vassiliki A. , Briers Laura , Pirintsos Stergios , Studholme David J. , Pavlidis Pavlos , Sarris Panagiotis F. 
Published: January 2020

AbstractBackgroundCrop wild relatives (CWRs) contain genetic diversity, representing an invaluable resource for crop improvement. Many of their traits have the potential to help crops to adapt to changing conditions that they experience due to climate change. An impressive global effort for the conservation of various CWR will facilitate their use in crop breeding for food security.The genusBrassicais listed in Annex I of the International Treaty on Plant Genetic Resources for Food and Agriculture.Brassica oleracea(or wild cabbage), a species native to southern and western Europe, has become established as an important human food crop plant because of its large reserves stored over the winter in its leaves.Brassica creticaLam. (Bc) is a CWR in the brassica group andB. creticasubsp.nivea(Bcn) has been suggested as a separate subspecies. The speciesBchas been proposed as a potential gene donor to brassica crops, including broccoli, cabbage, cauliflower, oilseed rape, etc.ResultsWe sequenced genomes of fourBcindividuals, including twoBcnand twoBc. Demographic analysis based on our whole-genome sequence data suggests that populations ofBcare not isolated. Classification of theBcinto distinct subspecies is not supported by the data. Using only the non-coding part of the data (thus, the parts of the genome that has evolved nearly neutrally), we find the gene flow between differentBcpopulation is recent and its genomic diversity is high.ConclusionsDespite predictions on the disruptive effect of gene flow in adaptation, when selection is not strong enough to prevent the loss of locally adapted alleles, studies show that gene flow can promote adaptation, that local adaptations can be maintained despite high gene flow, and that genetic architecture plays a fundamental role in the origin and maintenance of local adaptation with gene flow. Thus, in the genomic era it is important to link the selected demographic models with the underlying processes of genomic variation because, if this variation is largely selectively neutral, we cannot assume that a diverse population of crop wild relatives will necessarily exhibit the wide-ranging adaptive diversity required for further crop improvement.
Pertussis in infants, in their mothers and other contacts in Casablanca, Morocco
Authors: Katfy Khalid , Diawara Idrissa , Maaloum Fakhredine , Aziz Siham , Guiso Nicole , Fellah Hassan , Slaoui Bouchra , Zerouali Khalid , Belabbes Houria , Elmdaghri Naima 
Published: January 2020

Abstract
Background
In recent decades, there has been a marked increase in the number of reported cases of pertussis around the world, and pertussis continues to be a frequently occurring disease despite an effective childhood vaccination. This study aims to determine the role of household contacts of children diagnosed with pertussis in Casablanca Morocco.

Methods
From November 2015 to October 2017, children suspected of whooping cough that consulted Ibn Rochd University hospital at Casablanca with their household contacts were enrolled in the study. Nasopharyngeal (NP) samples of the suspected children were analyzed by culture and RT-PCR. For the household contacts, NP and blood samples were collected and analyzed by RT-PCR and specific detection of pertussis toxin antibodies by ELISA, respectively.

Results
During the study period, the survey was carried out on 128 infants hospitalized for pertussis suspicion and their families (N = 140). B. pertussis DNA was specifically detected in 73 (57%) samples, coexistence of B. pertussis and B. parapertussis DNA in 3 (2.3%) samples, coexistence of B. pertussis and B. holmesii DNA in 10 (7.81%) and only one (0.78%) sample was IS 481 RT-PCR positive without the possibility of determining the Bordetella species with the diagnostic tools used. Confirmations of Pertussis infection in household contacts by culture, RT- PCR and serology were 10, 46 and 39%, respectively.
B. pertussis DNA was confirmed in the infants as well in their mothers in 38% of the cases. Co detection of B. pertussis and B. parapertussis DNA in 2% and co-detection of B. pertussis and B. holmesii DNA in 4%. B. holmesii DNA alone was detected in 5 NP samples of index cases and their mothers.

Conclusions
The results of this study confirm that B. pertussis is still circulating in children and adults, and were likely a source of pertussis contamination in infants still not vaccinated. The use of RT-PCR specific for B. pertussis in the diagnosis of adults is less sensitive and should be associated with serologic tests to improve diagnosis of pertussis and contributes to preventing transmission of the disease in infants.
Acute tubulointerstitial nephritis in children– a retrospective case series in a UK tertiary paediatric centre
Authors: Roy S. , Awogbemi T. , Holt R. C. L. 
Published: January 2020

AbstractBackgroundAcute tubulointerstitial nephritis (AIN) is an uncommon cause of acute kidney injury in children, accounting for less than 10% of cases. There is limited information regarding the range of underlying diagnoses and how these may differ geographically.We undertook a retrospective case note review of consecutive cases of biopsy-proven AIN, presenting to a single UK tertiary paediatric centre, to describe the range of AIN in our caseload, define key characteristics and response to treatment, with the aim of informing paediatric nephrology practice.MethodsCases were identified retrospectively from departmental records. Data extracted included demographics, presenting clinical and biochemical features, renal biopsy histology, treatment and follow-up.ResultsTen cases were identified over 8 years (2007–2014). Age range 6–16 years. Male:Female ratio 1:9. Final diagnoses included 6 tubulointerstitial nephritis and uveitis syndrome (TINU), 2 idiopathic, 1 sarcoidosis, 1 child with Streptococcal disease. Of the TINU cases, timing of eye symptoms varied in relation to AIN presentation. Cases had a varied investigative work-up.Median presenting plasma creatinine was 303 μmol/l (range 152–932 μmol/l). Renal function improved spontaneously in 1 idiopathic case and improved with antimicrobial treatment in a child with Streptococcal disease.Eight cases received immunosuppressive treatment with intravenous methylprednisolone (approximately 10 mg/kg for 3–5 days) and / or oral prednisolone (1–2 mg/kg initially, reducing over 7–28 days).At 1 month, median creatinine had fallen to 91 μmol/l (range 41–120 μmol/l) with median eGFR 61 ml/min/1.73m2(range 51-103 ml/min/1.73m2). At last follow-up (median 18.5 months, range 2–70 months), median creatinine was 71 μmol/l (range 47–90 μmol/l) with median eGFR 80 ml/min/1.73m2, range 63 to 101 ml/min/1.73m2).Two patients received antihypertensives at diagnosis and 1 further patient at 1 month follow-up. Eight patients received electrolyte supplementation. Median time to discontinuing electrolyte supplementation was 3.5 months (range 1–12 months).ConclusionTo our knowledge, this is the only contemporary UK case series of biopsy-proven AIN in children. Our population has a high proportion of TINU. Treatment was accompanied by improvement of renal function, however 7/10 patients had an eGFR < 90 ml/min/1.73m2at last follow-up. We suggest a standardised investigative work-up and recommend long-term follow-up.