bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Cradle to Grave: How Childhood and Current Environments Impact Consumers’ Subjective Life Expectancy and Decision-Making
Authors: Mittal Chiraag , Griskevicius Vladas , Haws Kelly L 
Published: January 2020

Abstract
The age to which people expect to live likely drives many important consumer decisions. Yet we know surprisingly little about the antecedents and consequences of consumers’ subjective life expectancies. In the present work, we propose that subjective life expectancy is influenced by the combination of people’s childhood environment and their current environment. We find that people who grew up in poorer environments expected to have a shorter lifespan compared to people who grew up in richer environments when faced with a current stressor. We document that experiencing a stressor leads people from resource-poor childhoods to believe they will die sooner because they respond to stressors in a more pessimistic way. We further show that subjective life expectancy is an important psychological mechanism that directly contributes to multiple consumer decisions, including desire for long-term care insurance, decisions about retirement savings, and preference for long-term bonds. Overall, the present work opens future research avenues by showing how, why, and when subjective life expectancy influences consumer behavior.
Findings on repaired full-thickness acetabular articular cartilage defects during revision hip arthroscopy allowing a second look
Authors: Arriaza Carlos R , Sampson Thomas G , Olivos Meza Anell , Mendez-Vides Ana Cecilia 
Published: January 2020

Abstract
Full-thickness acetabular articular cartilage defects (FAACD) are found on most hips with femoroacetabular impingement (FAI) with a wave sign in the acetabulum. When not repaired it can produce pain and catching sensation. Multiple arthroscopic techniques for repairing this chondral lesion exist, but only few show the quality of the repair on a second look. The purpose of this study is to evaluate the quality of the repaired cartilage during revision hip arthroscopy (RHA) allowing a second look in patients treated of FAACD. A total of 13 hips with FAACD repaired in the past underwent RHA for ongoing pain. Signs of persistent chondral defects or the ability to elevate the articular cartilage from subchondral bone were evaluated by zones. Those with persistent defects were re-repaired. All patients had FAACD lesions in zones I, II and III diagnosed in the index hip arthroscopy. The most common finding at the RHA was the presence of bone growth or residual impingement. Before FAACD repair, 11 (85%) hips had the wave sign, while 2 (15%) hips had it in RHA. Five (38%) hips had residual delamination in the second look, these patients had residual FAI, were ≥58 years or waited &gt;6 months to be revised. The wave sign was not observed in 85% of the revised hips, indicating the technique was successful in most cases and was not the principal cause of their ongoing pain. This technique achieved the stated goal of stabilizing the articular cartilage seen in the wave sign.
Moderate water stress in rice induces rhizosheath formation associated with abscisic acid and auxin responses
Authors: Zhang Yingjiao , Du Huan , Gui Yao , Xu Feiyun , Liu Jianping , Zhang Jianhua , Xu Weifeng 
Published: January 2020

Abstract
The rhizosheath is known to be beneficial for drought resistance in many plants, but the regulation of rhizosheath formation in rice plants is unclear. Here, we investigate rhizosheath formation in different rice varieties and root hair mutants. Our results showed that moderate water stress in rice induced rhizosheath formation. The soil porosity and water content were higher in the rice rhizosheath than in the rice bulk soil under moderate water stress. Additionally, rhizosheath formation in short root hair mutants was lower than in wild-type rice under moderate water stress. Moreover, transcriptomic results indicated that abscisic acid (ABA) and auxin were involved in root and root hair responses in rhizosheath formation. Further, blocking ABA and auxin pathways in wild type and in rhl1-1, the shortest root hair mutant, rhizosheath formation and root hair length were significantly decreased under moderate water stress. However, wild type plants maintained a higher root ABA content, root basipetal auxin transport, root hair length, and amount of rhizosheath than did rhl1-1. Our results suggest that moderate water stress in rice induces rhizosheath formation by modulating the ABA and auxin responses to regulate root and root hair growth, which may be used to breed rice varieties resistant to drought.
A Gemini/GMOS study of the bright elliptical galaxy NGC 3613 and its globular cluster system
Authors: De Bórtoli Bruno J , Bassino Lilia P , Caso Juan P , Ennis Ana I 
Published: January 2020

ABSTRACT
We present the first photometric study of the globular cluster system (GCS) of the E galaxy NGC 3613 (MV = −21.5, d ∼ 30.1 Mpc), as well as the surface photometry of the host galaxy, based on Gemini/GMOS images. Being considered the central galaxy of a group, NGC 3613 inhabits a low-density environment although its intrinsic brightness is similar to the expected one for galaxies in the centre of clusters. The following characteristics are obtained for this GCS. The colour distribution is bimodal, with metal-poor globular clusters (GCs) getting slightly bluer with increasing radius. The radial and azimuthal projected distributions show that metal-rich GCs are more concentrated towards the host galaxy and trace its light distribution very precisely, while metal-poor GCs present a more extended and uniform distribution. The GC luminosity function helps validate the adopted distance. The estimated total GC population of Ntot = 2075 ± 130 leads to a specific frequency SN = 5.2 ± 0.7, a value within the expected range for GCSs with host galaxies of similar luminosity. The surface photometry of NGC 3613 reveals a three-component profile and a noticeable substructure. Finally, a small sample of ultracompact dwarf candidates are identified in the surroundings of the host galaxy.
The impact of wind scalings on stellar growth and the baryon cycle in cosmological simulations
Authors: Huang Shuiyao , Katz Neal , Davé Romeel , Oppenheimer Benjamin D , Weinberg David H , Fardal Mark , Kollmeier Juna A , Peeples Molly S 
Published: January 2020

ABSTRACT
Many phenomenologically successful cosmological simulations employ kinetic winds to model galactic outflows. Yet systematic studies of how variations in kinetic wind scalings might alter observable galaxy properties are rare. Here we employ gadget-3 simulations to study how the baryon cycle, stellar mass function, and other galaxy and CGM predictions vary as a function of the assumed outflow speed and the scaling of the mass-loading factor with velocity dispersion. We design our fiducial model to reproduce the measured wind properties at 25 per cent of the virial radius from the Feedback In Realistic Environments simulations. We find that a strong dependence of η ∼ σ5 in low-mass haloes with $\sigma \lt 106\mathrm{\, km\, s^{-1}}$ is required to match the faint end of the stellar mass functions at $z$ &gt; 1. In addition, faster winds significantly reduce wind recycling and heat more halo gas. Both effects result in less stellar mass growth in massive haloes and impact high ionization absorption in halo gas. We cannot simultaneously match the stellar content at $z$ = 2 and 0 within a single model, suggesting that an additional feedback source such as active galactic nucleus might be required in massive galaxies at lower redshifts, but the amount needed depends strongly on assumptions regarding the outflow properties. We run a 50 $\mathrm{Mpc}\, h^{-1}$, 2 × 5763 simulation with our fiducial parameters and show that it matches a range of star-forming galaxy properties at $z$ ∼ 0–2.
NCI-CONNECT: Comprehensive Oncology Network Evaluating Rare CNS Tumors—Histone Mutated Midline Glioma Workshop Proceedings*
Authors: Theeler Brett J , Dalal Yamini , Monje Michelle , Shilatifard Ali , Suvà Mario L , Aboud Orwa , Camphausen Kevin , Cordova Christine , Finch Elizabeth , Heiss John D , Packer Roger J , Romo Carlos G , Aldape Kenneth , Penas-Prado Marta , Armstrong Terri , Gilbert Mark R 
Published: January 2020

Abstract
Histone mutations occur in approximately 4% of different cancer types. In 2012, mutations were found in the gene encoding histone variant H3.3 (H3F3A gene) in pediatric diffuse intrinsic pontine gliomas and pediatric hemispheric gliomas. Tumors with mutations in the H3F3A gene are generally characterized as histone mutated gliomas (HMGs) or diffuse midline gliomas. HMGs are a rare subtype of glial tumor that is malignant and fast growing, carrying a poor prognosis. In 2017, the Beau Biden Cancer Moonshot Program appropriated $1.7 billion toward cancer care in 10 select areas. The National Cancer Institute (NCI) was granted support to focus specifically on rare central nervous system (CNS) tumors through NCI-CONNECT. Its mission is to address the challenges and unmet needs in CNS cancer research and treatment by connecting patients, providers, researchers, and advocacy organizations to work in partnership. On September 27, 2018, NCI-CONNECT convened a workshop on histone mutated midline glioma, one of the 12 CNS cancers included in its initial portfolio. Three leaders in the field provided an overview of advances in histone mutated midline glioma research. These experts shared observations and experiences related to common scientific and clinical challenges in studying these tumors. Although the clinical focus of this workshop was on adult patients, one important objective was to start a collaborative dialogue between pediatric and adult clinicians and researchers. Meeting participants identified needs for diagnostic and treatment standards, disease biology and biological targets for this cancer, disease-specific trial designs, and developed a list of action items and future direction.
Hope on the Horizon: Novel Fungal Treatments in Development
Authors: Rauseo Adriana M , Coler-Reilly Ariella , Larson Lindsey , Spec Andrej 
Published: January 2020

AbstractThe treatment of invasive fungal infections remains challenging due to limitations in currently available antifungal therapies including toxicity, interactions, restricted routes of administration, and drug resistance. This review focuses on novel therapies in clinical development, including drugs and a device. These drugs have novel mechanisms of action to overcome resistance, and some offer new formulations providing distinct advantages over current therapies to improve safety profiles and reduce interactions. Among agents that target the cell wall, 2 glucan synthesis inhibitors are discussed (rezafungin and ibrexafungerp), as well as fosmanogepix and nikkomycin Z. Agents that target the cell membrane include 3 fourth-generation azoles, oral encochleated amphotericin B, and aureobasidin A. Among agents with intracellular targets, we will review olorofim, VL-2397, T-2307, AR-12, and MGCD290. In addition, we will describe neurapheresis, a device used as adjunctive therapy for cryptococcosis. With a field full of novel treatments for fungal infections, the future looks promising.
Multiple NDM-5-Expressing Escherichia Coli Isolates From an Immunocompromised Pediatric Host
Authors: Flerlage Tim , Brazelton de Cardenas Jessica N , Garner Cherilyn D , Hasan Nur A , Karathia Hiren , Qudeimat Amr , Maron Gabriela , Hayden Randall 
Published: January 2020

Abstract

Background
Genes conferring carbapenem resistance have disseminated worldwide among Gram-negative bacteria. Here we present longitudinal changes in clinically obtained Escherichia coli isolates from 1 immunocompromised pediatric patient. This report demonstrates potential for antibiotic resistance genes and plasmids to emerge over time in clinical isolates from patients receiving intensive anticancer chemotherapy and broad-spectrum antibiotics.

Methods
Thirty-three isolates obtained over 7 months from 1 patient were included. Clinical data were abstracted from the medical record. For each isolate, studies included phenotypic antibacterial resistance patterns, sequence typing, bacterial isolate sequencing, plasmid identification, and antibiotic resistance gene identification.

Results
Sites of isolation included blood, wound culture, and culture for surveillance purposes from the perianal area. Isolates were of 5 sequence types (STs). All were resistant to multiple classes of antibiotics; 23 (69.6%) were phenotypically resistant to all carbapenems. The blaNDM-5 gene was identified in 22 (67%) isolates, all of ST-167 and ST-940, and appeared to coincide with the presence of the IncFII and IncX3 plasmid.

Conclusions
We present unique microbiologic data from 33 multidrug-resistant E. coli isolates obtained over the course of 7 months from an individual patient in the United States. Two E. coli sequence types causing invasive infection in the same patient and harboring the blaNDM-5 gene, encoded on the IncX3 plasmid and the IncFII plasmid, were identified. This study highlights the emergence of multidrug-resistant bacteria on antibiotic therapy and the necessity of adequate neutrophil number and function in the clearance of bacteremia.
Burr Hole-Assisted Direct Transsylvian Venous Catheterization for Carotid-Cavernous Fistula Embolization: A Case Report
Authors: Ghosh Ritam , Al Saiegh Fadi , Mahtabfar Aria , Mouchtouris Nikolaos , Khanna Omaditya , Sweid Ahmad , Chalouhi Nohra , Lebovitz Jonathon , Tjoumakaris Stavropoula , Gooch M Reid , Rosenwasser Robert H , Jabbour Pascal M 
Published: January 2020

Abstract

BACKGROUND AND IMPORTANCE
Carotid-cavernous fistulas (CCF) are pathological connections between carotid artery branches and the cavernous sinus. They can lead to a variety of symptoms, such as chemosis and double vision, or more insidious events, such as vision loss and intracranial hemorrhage. Although these patients are often treated by endovascular means, we describe a case in which the patient's CCF was not able to be accessed by usual methods and required an open surgical approach.

CLINICAL PRESENTATION
The patient had progressive chemosis, double vision, and periorbital pain. Angiogram showed an indirect type D CCF with cortical venous drainage with a large sylvian vein that was directly draining the fistula. The patient did not have a dilated superior ophthalmic vein, and the petrosal sinuses could not be catheterized. Therefore, because of the patient's increased risk for intracranial hemorrhage, she was taken to the operating room for an image guided burr hole for direct catheterization of the sylvian vein. From this point, the fistulous point could be catheterized, and the CCF was embolized using onyx. Follow-up angiogram showed complete occlusion.

CONCLUSION
This is the first report in literature of an indirect CCF being treated through a transsylvian approach with onyx. This combined open-surgical-and-endovascular approach was necessary to get full resolution of the lesion, and patient had rapid improvement of symptoms.
Transcriptomic Analysis of the Grapevine LEA Gene Family in Response to Osmotic and Cold Stress Reveals a Key Role for VamDHN3
Authors: Xu Meilong , Tong Qian , Wang Yi , Wang Zemin , Xu Guangzhao , Elias Gathunga Kirabi , Li Shaohua , Liang Zhenchang 
Published: January 2020

Abstract
Late embryogenesis abundant (LEA) proteins comprise a large family that plays important roles in the regulation of abiotic stress, however, no in-depth analysis of LEA genes has been performed in grapevine to date. In this study, we analyzed a total of 52 putative LEA genes in grapevine at the genomic and transcriptomic level, compiled expression profiles of four selected (V. amurensis) VamLEA genes under cold and osmotic stresses, and studied the potential function of the V. amurensis DEHYDRIN3 (VamDHN3) gene in grapevine callus. The 52 LEA proteins were classified into seven phylogenetic groups. RNA-seq and quantitative real-time PCR results demonstrated that a total of 16 and 23 VamLEA genes were upregulated under cold and osmotic stresses, respectively. In addition, overexpression of VamDHN3 enhanced the stability of the cell membrane in grapevine callus, suggesting that VamDHN3 is involved in osmotic regulation. These results provide fundamental knowledge for the further analysis of the biological roles of grapevine LEA genes in adaption to abiotic stress.
Brain-Derived Neurotrophic Factor Modulates the Effect of Sex on the Descending Pain Modulatory System in Healthy Volunteers
Authors: Gasparin Assunta , Zortea Maxciel , dos Santos Vinicius Souza , Carvalho Fabiana , Torres Iraci L S , de Souza Andressa , Fregni Felipe , Caumo Wolnei 
Published: January 2020

Abstract

Objectives
We investigated sex differences and the influence of brain-derived neurotrophic factor (BDNF) in the descending pain modulatory system (DPMS), as measured by change on the numerical pain scale (NPS; 0–10) during conditioned pain modulation (CPM task; primary outcome) and by function of the corticospinal motor pathway and heat pain thresholds (HPTs; secondary outcomes).

Methods
This cross-sectional study included healthy volunteers ranging in age from 18 to 45 years (32 male and 24 female). Assessment included serum BDNF, HPT, change on the NPS (0–10) during the CPM task, and motor-evoked potential (MEP) using transcranial magnetic stimulation (TMS).

Results
The MEP (Mv) amplitude was larger in male participants compared with female participants (mean [SE] = 1.55 [0.34] vs mean [SE] = 1.27 [0.27], respectively, P = 0.001). The mean NPS (0–10) during CPM task changed more substantially for female compared with male participants (mean [SE] = −3.25 [2.01] vs mean [SE] = −2.29 [1.34], respectively, P = 0.040). In addition, a higher serum BDNF (adjusted index for age) was associated with a larger decrease of the NPS during CPM task (P = 0.003), although further regression analyses by sex showed that this was only significant for females (P = 0.010).

Conclusions
Significant sex differences were identified in DPMS function and corticospinal motor pathway integrity. Nevertheless, BDNF was associated with the function of the DPMS in female but not male participants, indicating that sex and neuroplasticity state are crucial factors for pain perception in healthy subjects.
Measuring the effectiveness of catch-up MMR delivered by school nurses compared to signposting to general practice on improving MMR coverage
Authors: Altinoluk-Davis F , Gray S , Bray I 
Published: January 2020

Abstract

Background
This study assesses whether increased coverage of the measles, mumps and rubella (MMR) vaccination differs between areas where school nurses deliver catch-up MMR doses to adolescents in school settings, compared to signposting to general practice.

Methods
A retrospective cohort study was conducted using Child Health Information Services records within the NHS England South (South Central) commissioning boundary. The sample population included children born 1 September 2000–31 August 2001, in school year 9 during the 2014–15 academic year.

Results
The primary outcome findings show an increase in coverage of at least one dose of MMR by 1.6% (n = 334) in the cohort receiving catch-up MMR, compared to 0.2% (n = 12) in the cohort signposted to general practice. Over time, the difference in increase between the two cohorts was 1.4%, analysed using the chi-squared comparison of proportions test, providing strong evidence (P &lt; 0.0001) that school nurse delivery of catch-up MMR is effective at increasing coverage. The findings also suggest that school nurse delivery of catch-up MMR may benefit Black, Asian and minority ethnic children and those from more deprived backgrounds.

Conclusions
It is recommended that commissioners of school-aged immunization services incorporate the delivery of catch-up MMR doses in their contracts with school nurses.
Poly(methyl methacrylate) bone cement composited with mineralized collagen for osteoporotic vertebral compression fractures in extremely old patients
Authors: Luo Kefeng , Jiang Guoqiang , Zhu Jinjin , Lu Bin , Lu Jiye , Zhang Kai , Wang Xiumei , Cui Fu-Zhai 
Published: January 2020

Abstract
To examine the clinical effects of a new bone cement composed of poly(methyl methacrylate) (PMMA) and mineralized collagen (MC) compared with pure PMMA bone cement in treating osteoporotic vertebral compression fractures (OVCFs) in patients aged over 80. In all, 32 cases using pure PMMA bone cement and 31 cases using MC-modified PMMA (MC-PMMA) bone cement for OVCFs between June 2014 and March 2016 were screened as PMMA group and MC-PMMA group, respectively, with an average age of over 80. The operation duration, intraoperative blood loss, hospital stay, oswestry disability index (ODI), visual analogue scale (VAS), anterior vertebral height (AVH), intermediate vertebral height (IVH) and posterior vertebral height (PVH) of injured vertebrae, vertebral computed tomography value, re-fracture rate of adjacent vertebrae, correction rate of spinal kyphotic angle and wedge-shaped vertebra angle and surgical complications were compared between the two groups. In the early post-operative period, the VAS, ODI, AVH and IVH in MC-PMMA group were comparable to those in the traditional PMMA group. Moreover, the MC-PMMA group showed better effects compared with the PMMA group 12 months after surgery. Thus, this new bone cement has superior clinic effects in the long term.
Stella Chess and the History of American Child Psychiatry
Authors: Hirshbein Laura D. 
Published: January 2020

Summary
Throughout its history, American child psychiatry has been a hospitable specialty for women physicians. In its early years when practitioners were often steeped in psychoanalysis and influenced by theorists such as Anna Freud, many leaders within the field were women. By the 1960s and 1970s, child psychiatry was moving away from analysis and towards more research-based practice. The biography of an important leader in this area, New York University’s Stella Chess, illustrates the mechanism of that transformation and the role of ideas about mothers and working women. Chess, along with her husband and collaborator Alexander Thomas, gathered data to disprove the popular notion that mothers were to blame for children’s behaviour problems and demonstrated instead that issues resulted from a poor fit between a child’s temperament and his/her environment. Chess not only demanded that facts support theory, but also used her own parenting experiences and common sense to guide her work.
“This Lady, She’s A-List!”: The Empowerment Impact of Womxn Political Elites for Womxn in South African Higher Education
Authors: Michalko Ján 
Published: January 2020

AbstractThis article analyzes the norms that are expected of womxn political elites as role models, to further advance the research on the contributions of womxn in politics to womxn’s empowerment. Based on interviews and group discussions with womxn at the University of Johannesburg, South Africa, it is argued that womxn in politics contribute to the students’ normative construction of their ideal self and hence to their empowerment. Consequently, it is suggested that development interventions focus on womxn in politics as fully embedded in wider normative structures while also exposing womxn to a diverse group of womxn in power.