bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective total syntheses of (+)-stemofoline and three congeners based on a biogenetic hypothesis
Authors: Huang Xiong-Zhi , Gao Long-Hui , Huang Pei-Qiang 
Published: October 2020

AbstractThe powerful insecticidal and multi-drug-resistance-reversing activities displayed by the stemofoline group of alkaloids render them promising lead structures for further development as commercial agents in agriculture and medicine. However, concise, enantioselective total syntheses of stemofoline alkaloids remain a formidable challenge due to their structural complexity. We disclose herein the enantioselective total syntheses of four stemofoline alkaloids, including (+)-stemofoline, (+)-isostemofoline, (+)-stemoburkilline, and (+)-(11S,12R)-dihydrostemofoline, in just 19 steps. Our strategy relies on a biogenetic hypothesis, which postulates that stemoburkilline and dihydrostemofolines are biogenetic precursors of stemofoline and isostemofoline. Other highlights of our approach are the use of Horner–Wadsworth–Emmons reaction to connect the two segments of the molecule, an improved protocol allowing gram-scale access to the tetracyclic cage-type core, and a Cu-catalyzed direct and versatile nucleophilic alkylation reaction on an anti-Bredt iminium ion. The synthetic techniques that we developed could also be extended to the preparation of other Stemona alkaloids.
Reduction of mortality and predictions for acute myocardial infarction, stroke, and heart failure in Brazil until 2030
Authors: Siqueira Camila Alves dos Santos , de Souza Dyego Leandro Bezerra 
Published: October 2020

AbstractCardiovascular diseases (CVD) are responsible for the majority of deaths in Brazil and worldwide, and constitute an important share of non-transmissible diseases. The objective of this study is to analyze the mortality trends of the three main CVD in Brazil and its geographic regions: acute myocardial infarction, stroke, and heart failure. Data predictions until 2030 were also carried out. An ecological study is presented herein, with data for the period 2001–2015. Mortality from these diseases was evaluated by annual trends, and grouped in five-year intervals for the predictions until 2030. All data are publicly available. Acute myocardial infarction was the leading isolated cause of death. Brazilian trends revealed a decrease in the three diseases, with different patterns across geographic regions. The Southeast, South, and Midwest regions presented reductions for the three diseases. The predictions indicated higher rates for men. There was also a reduction in the risk of death from these diseases for Brazil and, despite the different mortality patterns for the three diseases, the Southeast region presents, primarily, lower predicted rates than the other regions. The assessment of trends and predictions for the three main CVD in Brazil revealed general decreasing trends with differences across the geographic regions.
RETRACTED ARTICLE: A mechanistic model of the neural entropy increase elicited by psychedelic drugs
Authors: Herzog Rubén , Mediano Pedro A. M. , Rosas Fernando E. , Carhart-Harris Robin , Perl Yonatan Sanz , Tagliazucchi Enzo , Cofre Rodrigo 
Published: October 2020

AbstractPsychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain’s anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.
Psychological resilience is correlated with dynamic changes in functional connectivity within the default mode network during a cognitive task
Authors: Miyagi Takashi , Oishi Naoya , Kobayashi Kei , Ueno Tsukasa , Yoshimura Sayaka , Murai Toshiya , Fujiwara Hironobu 
Published: October 2020

AbstractResilience is a dynamic process that enables organisms to cope with demanding environments. Resting-state functional MRI (fMRI) studies have demonstrated a negative correlation between resilience and functional connectivities (FCs) within the default mode network (DMN). Considering the on-demand recruitment process of resilience, dynamic changes in FCs during cognitive load increases may reflect essential aspects of resilience. We compared DMN FC changes in resting and task states and their association with resilience. Eighty-nine healthy volunteers completed the Connor–Davidson Resilience Scale (CD-RISC) and an fMRI with an auditory oddball task. The fMRI time series was divided into resting and task periods. We focused on FC changes between the latter half of the resting period and the former half of the task phase (switching), and between the former and latter half of the task phase (sustaining). FCs within the ventral DMN significantly increased during “switching” and decreased during “sustaining”. For FCs between the retrosplenial/posterior cingulate and the parahippocampal cortex, increased FC during switching was negatively correlated with CD-RISC scores. In individuals with higher resilience, ventral DMN connectivities were more stable and homeostatic in the face of cognitive demand. The dynamic profile of DMN FCs may represent a novel biomarker of resilience.
Radiative mixed convection flow of maxwell nanofluid over a stretching cylinder with joule heating and heat source/sink effects
Authors: Islam Saeed , Khan Arshad , Kumam Poom , Alrabaiah Hussam , Shah Zahir , Khan Waris , Zubair Muhammad , Jawad Muhammad 
Published: October 2020

AbstractThis work analyses thermal effect for a mixed convection flow of Maxwell nanofluid spinning motion produced by rotating and bidirectional stretching cylinder. Impacts of Joule heating and internal heat source/sink are also taken into account for current investigation. Moreover, the flow is exposed to a uniform magnetic field with convective boundary conditions. The modeled equations are converted to set of ODEs through group of similar variables and are then solved by using semi analytical technique HAM. It is observed in this study that, velocity grows up with enhancing values of Maxwell, mixed convection parameters and reduces with growing values of magnetic parameter. Temperature jumps up with increasing values of heat source, Eckert number, Brownian motion,thermophoresis parameter and jumps down with growing values of Prandtl number and heat sink. The concentration is a growing function of thermophoresis parameter and a reducing function of Brownian motion and Schmidt number.
Tracking elemental changes in an ischemic stroke model with X-ray fluorescence imaging
Authors: Pushie M. J. , Sylvain N. J. , Hou H. , Caine S. , Hackett M. J. , Kelly M. E. 
Published: October 2020

AbstractStroke is a leading cause of long-term disability in adults and a leading cause of death in developed nations. The cascade of cellular events and signalling that occur after cerebral ischemia are complex, however, analyzing global element markers of metabolic state affords the means to monitor stroke severity, status of injury, and recovery. These markers provide a multi-parameter method for assessing changes through the post-stroke time course. We employ synchrotron-based elemental mapping to follow elemental changes in the brain at 1 h, 1-, 2-, and 3-days, and at 1-, 2-, 3-, and 4-weeks post-stroke in a photothrombotic stroke model in mice. Our analysis reveals a highly consistent metabolic penumbra that can be readily identified based on the level of dysregulated potassium and other key elements. Maps of elemental distributions are also useful to demarcate events in the cellular response to the inflammatory cascade, including ion dysregulation, recruitment of cells to the lesion, and glial scar formation.
Subtle executive deficits are associated with higher brain amyloid burden and lower cortical volume in subjective cognitive decline: the FACEHBI cohort
Authors: Pérez-Cordón Alba , Monté-Rubio Gemma , Sanabria Angela , Rodriguez-Gomez Octavio , Valero Sergi , Abdelnour Carla , Marquié Marta , Espinosa Ana , Ortega Gemma , Hernandez Isabel , Rosende-Roca Maitee , Vargas Liliana , Mauleón Ana , Gil Silvia , Tartari Juan Pablo , Lomeña Francisco , Campos Francisco , Vivas Assumpta , Gomez-Chiari Marta , Benaque Alba , Ruiz Agustin , Tárraga Luis , Boada Mercè , Alegret Montserrat ,   FACEHBI Group, Aguilera N. , Berthier M. , Buendia M. , Bullich S. , Cañabate P. , Cuevas C. , de Rojas I. , Gailhajenet A. , Diego S. , Giménez J. , Gismondi R. , Guitart M. , Ibarria M. , Lafuente A. , Martín E. , Martínez J. , Moreno M. , Moreno-Grau S. , Núñez L. , Orellana A. , Páez A. , Pancho A. , Pavía J. , Pelejà E. , Pérez-Grijalba V. , Pesini P. , Preckler S. , Romero J. , Montrreal L. , Sarasa M. , Sotolongo-Grau O. , Tejero M. A. , Torres M. 
Published: October 2020

AbstractTo determine whether lower performance on executive function tests in subjective cognitive decline (SCD) individuals are associated with higher levels of brain amyloid beta (Aβ) deposition and regional volumetric reduction in areas of interest for Alzheimer’s disease (AD). 195 individuals with SCD from the FACEHBI study were assessed with a neuropsychological battery that included the following nine executive function tests: Trail Making Test A and B (TMTA, TMTB), the Rule Shift Cards subtest of BADS, the Automatic Inhibition subtest of the Syndrom Kurz Test (AI-SKT), Digit Span Backwards and Similarities from WAIS-III, and the letter, semantic, and verb fluency tests. All subjects underwent an 18F-Florbetaben positron emission tomography (FBB-PET) scan to measure global standard uptake value ratio (SUVR), and a magnetic resonance imaging (MRI). A multiple regression analysis, adjusted for age, was carried out to explore the association between global SUVR and performance on executive tests. Then, on those tests significantly associated with amyloid burden, a voxel-based morphometry (VBM) analysis was carried out to explore their correlates with grey matter volume. Multiple regression analysis revealed a statistically significant association between Aβ deposition and performance on one of the executive tests (the AI-SKT). Moreover, VBM analysis showed worse AI-SKT scores were related to lower volume in bilateral hippocampus and left inferior frontal regions. In conclusion, in SCD individuals, worse automatic inhibition ability has been found related to higher cerebral Aβ deposition and lower volume in the hippocampus and frontal regions. Thus, our results may contribute to the early detection of AD in individuals with SCD.
Influence of low back pain and its remission on motor abundance in a low-load lifting task
Authors: Liew Bernard X. W. , De Nunzio Alessandro Marco , Srivastava Shraddha , Falla Deborah 
Published: October 2020

AbstractHaving an abundance of motor solutions during movement may be advantageous for the health of musculoskeletal tissues, given greater load distribution between tissues. The aim of the present study was to understand whether motor abundance differs between people with and without low back pain (LBP) during a low-load lifting task. Motion capture with electromyography (EMG) assessment of 15 muscles was performed on 48 participants [healthy control (con) = 16, remission LBP (rLBP) = 16, current LBP (cLBP) = 16], during lifting. Non-negative matrix factorization and uncontrolled manifold analysis were performed to decompose inter-repetition variability in the temporal activity of muscle modes into goal equivalent (GEV) and non-goal equivalent (NGEV) variabilities in the control of the pelvis and trunk linear displacements. Motor abundance occurs when the ratio of GEV to NGEV exceeds zero. There were significant group differences in the temporal activity of muscle modes, such that both cLBP and rLBP individuals demonstrated greater activity of muscle modes that reflected lumbopelvic coactivation during the lifting phase compared to controls. For motor abundance, there were no significant differences between groups. Individuals with LBP, including those in remission, had similar overall motor abundance, but use different activation profiles of muscle modes than asymptomatic people during lifting.
The tree of life of polyamine oxidases
Authors: Salvi Daniele , Tavladoraki Paraskevi 
Published: October 2020

AbstractPolyamine oxidases (PAOs) are characterized by a broad variability in catalytic properties and subcellular localization, and impact key cellular processes in diverse organisms. In the present study, a comprehensive phylogenetic analysis was performed to understand the evolution of PAOs across the three domains of life and particularly within eukaryotes. Phylogenetic trees show that PAO-like sequences of bacteria, archaea, and eukaryotes form three distinct clades, with the exception of a few procaryotes that probably acquired a PAO gene through horizontal transfer from a eukaryotic donor. Results strongly support a common origin for archaeal PAO-like proteins and eukaryotic PAOs, as well as a shared origin between PAOs and monoamine oxidases. Within eukaryotes, four main lineages were identified that likely originated from an ancestral eukaryotic PAO before the split of the main superphyla, followed by specific gene losses in each superphylum. Plant PAOs show the highest diversity within eukaryotes and belong to three distinct clades that underwent to multiple events of gene duplication and gene loss. Peptide deletion along the evolution of plant PAOs of Clade I accounted for further diversification of function and subcellular localization. This study provides a reference for future structure–function studies and emphasizes the importance of extending comparisons among PAO subfamilies across multiple eukaryotic superphyla.
Identifying indoor radon sources in Pa Miang, Chiang Mai, Thailand
Authors: Thumvijit Tarika , Chanyotha Supitcha , Sriburee Sompong , Hongsriti Pongsiri , Tapanya Monruedee , Kranrod Chutima , Tokonami Shinji 
Published: October 2020

AbstractRadon is the leading source of lung cancer mortality after smoking in Chiang Mai, Thailand. Finding a source of carcinogens is one of the important measures for preventing the cancer risk for this region. Specific sites at Pa Miang, Doi Saket have the highest incidences of lung cancer and have a combination of factors that influence indoor radon concentration. Our study identified the sources of indoor radon within several houses. The results indicate that geological and topographic characteristics, including active faults and mountain terraces, are the main sources of indoor radon, especially for wooden houses. Besides building materials, the design of the houses, ventilation conditions, and lifestyle choices are all factors influencing indoor radon concentrations and its associated risk. Although radon levels (29–101 Bq m−3) and total indoor annual effective doses (0.9–3.8 mSv year−1) received from all sources at these sites have shown no significant health risk due to radon exposure , this investigation will be useful as a starting point to guide strategies to respond and prevent the risk of lung cancer, especially in Chiang Mai.
Synthesis of an acyl-acyl carrier protein synthetase inhibitor to study fatty acid recycling
Authors: Currie Madeline F. , Persaud Dylan M. , Rana Niralee K. , Platt Amanda J. , Beld Joris , Jaremko Kara L. 
Published: October 2020

AbstractFatty acids are essential to most organisms and are made endogenously by the fatty acid synthase (FAS). FAS is an attractive target for antibiotics and many inhibitors are in clinical development. However, some gram-negative bacteria harbor an enzyme known as the acyl-acyl carrier protein synthetase (AasS), which allows them to scavenge fatty acids from the environment and shuttle them into FAS and ultimately lipids. The ability of AasS to recycle fatty acids may help pathogenic gram-negative bacteria circumvent FAS inhibition. We therefore set out to design and synthesize an inhibitor of AasS and test its effectiveness on an AasS enzyme fromVibrio harveyi, the most well studied AasS to date, and fromVibrio cholerae, a pathogenic model. The inhibitor C10-AMS [5′-O-(N-decanylsulfamoyl)adenosine], which mimics the tightly bound acyl-AMP reaction intermediate, was able to effectively inhibit AasS catalytic activity in vitro. Additionally, C10-AMS stopped the ability ofVibrio choleraeto recycle fatty acids from media and survive when its endogenous FAS was inhibited with cerulenin. C10-AMS can be used to study fatty acid recycling in other bacteria as more AasS enzymes continue to be annotated and provides a platform for potential antibiotic development.
On the robustness of the hybrid qubit computational gates through simulated randomized benchmarking protocols
Authors: Ferraro Elena , De Michielis Marco 
Published: October 2020

AbstractOne of the main challenges in building a quantum processor is to characterize the environmental noise. Noise characterization can be achieved by exploiting different techniques, such as randomization where several sequences of random quantum gates are applied to the qubit under test to derive statistical characteristics about the affecting noises. A scalable and robust algorithm able to benchmark the full set of Clifford gates using randomization techniques is called randomized benchmarking. In this study, we simulated randomized benchmarking protocols in a semiconducting all-electrical three-electron double-quantum dot qubit, i.e. hybrid qubit, under different error models, that include quasi-static Gaussian and the more realistic 1/f noise model, for the input controls. The average error of specific quantum computational gates is extracted through interleaved randomized benchmarking obtained including Clifford gates between the gate of interest. It provides an estimate of the fidelity as well as theoretical bounds for the average error of the gate under test.
Decrease of renal resistance during hypothermic oxygenated machine perfusion is associated with early allograft function in extended criteria donation kidney transplantation
Authors: Meister Franziska A. , Czigany Zoltan , Rietzler Katharina , Miller Hannah , Reichelt Sophie , Liu Wen-Jia , Boecker Joerg , Moeller Marcus J. , Tolba Rene H. , Hamesch Karim , Strnad Pavel , Boor Peter , Stoppe Christian , Neumann Ulf P. , Lurje Georg 
Published: October 2020

AbstractHypothermic oxygenated machine perfusion (HOPE) was recently tested in preclinical trials in kidney transplantation (KT). Here we investigate the effects of HOPE on extended-criteria-donation (ECD) kidney allografts (KA). Fifteen ECD-KA were submitted to 152 ± 92 min of end-ischemic HOPE and were compared to a matched group undergoing conventional-cold-storage (CCS) KT (n = 30). Primary (delayed graft function-DGF) and secondary (e.g. postoperative complications, perfusion parameters) endpoints were analyzed within 6-months follow-up. There was no difference in the development of DGF between the HOPE and CCS groups (53% vs. 33%, respectively; p = 0.197). Serum urea was lower following HOPE compared to CCS (p = 0.003), whereas the CCS group displayed lower serum creatinine and higher eGFR rates on postoperative days (POD) 7 and 14. The relative decrease of renal vascular resistance (RR) following HOPE showed a significant inverse association with serum creatinine on POD1 (r = − 0.682; p = 0.006) as well as with serum urea and eGFR. Besides, the relative RR decrease was more prominent in KA with primary function when compared to KA with DGF (p = 0.013). Here we provide clinical evidence on HOPE in ECD-KT after brain death donation. Relative RR may be a useful predictive marker for KA function. Further validation in randomized controlled trials is warranted.Trial registration: clinicaltrials.gov (NCT03378817, Date of first registration: 20/12/2017).
Blood pressure measurements with the OptiBP smartphone app validated against reference auscultatory measurements
Authors: Schoettker Patrick , Degott Jean , Hofmann Gregory , Proença Martin , Bonnier Guillaume , Lemkaddem Alia , Lemay Mathieu , Schorer Raoul , Christen Urvan , Knebel Jean-François , Wuerzner Arlene , Burnier Michel , Wuerzner Gregoire 
Published: October 2020

AbstractMobile health diagnostics have been shown to be effective and scalable for chronic disease detection and management. By maximizing the smartphones’ optics and computational power, they could allow assessment of physiological information from the morphology of pulse waves and thus estimate cuffless blood pressure (BP). We trained the parameters of an existing pulse wave analysis algorithm (oBPM), previously validated in anaesthesia on pulse oximeter signals, by collecting optical signals from 51 patients fingertips via a smartphone while simultaneously acquiring BP measurements through an arterial catheter. We then compared smartphone-based measurements obtained on 50 participants in an ambulatory setting via the OptiBP app against simultaneously acquired auscultatory systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) measurements. Patients were normotensive (70.0% for SBP versus 61.4% for DBP), hypertensive (17.1% vs. 13.6%) or hypotensive (12.9% vs. 25.0%). The difference in BP (mean ± standard deviation) between both methods were within the ISO 81,060–2:2018 standard for SBP (− 0.7 ± 7.7 mmHg), DBP (− 0.4 ± 4.5 mmHg) and MBP (− 0.6 ± 5.2 mmHg). These results demonstrate that BP can be measured with accuracy at the finger using the OptiBP smartphone app. This may become an important tool to detect hypertension in various settings, for example in low-income countries, where the availability of smartphones is high but access to health care is low.