bluuebunny/crossref_metadata_2025_split huggingface dataset:
Public servant stereotypes: It is not (at) all about being lazy, greedy and corrupt
Authors: Willems Jurgen 
Published: June 2020

AbstractAs stereotypes strongly influence social interactions, this study explores the stereotypical associations regarding public servants, and about various professions in the public sector as well as the for‐profit and nonprofit sectors. This leads to a better understanding of the theoretical and practical challenges, such as citizen behaviour towards public servants, attractiveness of and political decisions about public service jobs. With a mixed‐method analysis of cognitive associations (7,470 associations by 415 respondents for 12 professions), the defining epithets of public servants are clarified, along with their positive or negative connotation. Despite the strongest associations for public servants being positive (caring, helpful and dedicated), as an overall category, it has a less positive connotation compared to some specific professions typical in the public sector (nurse, firefighter and police). However, cognitive associations are substantially more positive for public servants compared to politicians, lawyers and salesmen.
Acute hematogenous pelvic osteomyelitis: appropriate timing for magnetic resonance imaging
Authors: Miyazaki Osamu , Tanaka Toshiyuki , Aoki Hidekazu , Okamoto Reiko , Tsutsumi Yoshiyuki , Miyasaka Mikiko , Nosaka Shunsuke 
Published: June 2020

AbstractBackgroundThe precise time of appearance of bone marrow edema in acute hematogenous pelvic osteomyelitis (AHPO) is unknown. The purpose of the present research is to clarify the time of appearance of bone marrow edema on magnetic resonance imaging (MRI) in AHPO. Our hypothesis was that onset is slower than in long‐bone osteomyelitis.MethodsWe selected 12 patients (mean, 11.8 years) with MRI findings and clinical diagnosis of AHPO. The signal ratios of bone marrow (BM) and gluteus maximus muscle (M, BM/M ratio) in fat‐suppressed T2‐ and T1‐weighted images (T2WI, T1WI) were calculated to evaluate changes in bone‐marrow signals. The correlation between BM/M ratios and days from onset was evaluated statistically and compared with lower extremity osteomyelitis.ResultsBone marrow/M ratio of T2WI increased over time after the onset of the primary symptom in all patients and showed a statistically positive correlation (r = 0.36). In seven patients in whom an MRI scan was conducted twice, all showed higher values for the second MRI, and changes were more pronounced over time. The mean BM/M ratio of T2WI was 4.1 when 7 days or less had elapsed from the primary symptom, and 6.4 when more than 7 days had elapsed. The BM/M ratios in the sacroiliac joint group were lower than in the non‐sacroiliac joint group.ConclusionsUnlike long‐bone osteomyelitis, it took 1 week before findings for AHPO became fully evident. A definitive diagnosis can be made in patients with suspected sacroiliitis by performing a further MRI scan at 7 days or later.
Characterization of a Bio‐sourced, Fluorescent, Ratiometric pH Indicator with Alkaline pKa
Authors: Alheety Samar , Valenti Domenic , Mujumdar Nirvani , Ellis Nakita , Campiglia Andres D. , Harper James K. , Heider Emily C. 
Published: June 2020

AbstractUtilizing organisms as sources of fluorophores relieves the demand for petroleum feedstock in organic synthesis of fluorescent products, and endophytic fungi provide a promising vein for natural fluorescent products. We report the characterization of a pH‐responsive fluorophore from an endophytic fungus isolated from sand pine. The endogenous fluorescence of the live organism was measured using fluorescence microscopy. Computational interpretation of the spectra was accomplished with time‐dependent density functional theory methods. The combined use of experimental and theoretically predicted spectra revealed the pH equilibria and photoexcited tautomerization of the natural product, 5‐methylmellein. This product shows promise both as a stand‐alone pH‐indicating fluorophore, with alkaline pKa, and as "green" feedstock for synthesis of custom fluorophores.
A Scalable Estimate of the Out-of-Sample Prediction Error via Approximate Leave-One-Out Cross-Validation
Authors: Rad Kamiar Rahnama , Maleki Arian 
Published: June 2020

SummaryThe paper considers the problem of out-of-sample risk estimation under the high dimensional settings where standard techniques such as K-fold cross-validation suffer from large biases. Motivated by the low bias of the leave-one-out cross-validation method, we propose a computationally efficient closed form approximate leave-one-out formula ALO for a large class of regularized estimators. Given the regularized estimate, calculating ALO requires a minor computational overhead. With minor assumptions about the data-generating process, we obtain a finite sample upper bound for the difference between leave-one-out cross-validation and approximate leave-one-out cross-validation, |LO−ALO|. Our theoretical analysis illustrates that |LO−ALO|→0 with overwhelming probability, when n, p → ∞, where the dimension p of the feature vectors may be comparable with or even greater than the number of observations, n. Despite the high dimensionality of the problem, our theoretical results do not require any sparsity assumption on the vector of regression coefficients. Our extensive numerical experiments show that |LO−ALO| decreases as n and p increase, revealing the excellent finite sample performance of approximate leave-one-out cross-validation. We further illustrate the usefulness of our proposed out-of-sample risk estimation method by an example of real recordings from spatially sensitive neurons (grid cells) in the medial entorhinal cortex of a rat.
Practical Knowledge, Equal Standing, and Proper Reliance on Others
Authors: Bagnoli Carla 
Published: June 2020

AbstractAccording to a traditional account, moral cognition is an achievement gained over time by sharing a practice under the guidance and the example of the wise, in analogy with craft and apprenticeship. This model captures an important feature of practical reason, that is, its incompleteness, and highlights our dependence on others in obtaining moral knowledge, coherently with the socially extended mind agenda and recent findings in empirical psychology. However, insofar as it accords to exemplars’ decisive authority to determine the standard of correctness for moral cognition, the model does not offer protection against arbitrariness and discrimination. The article argues that to understand the socially distributed nature of practical knowledge, we have to discard the notion of exemplars and reconceive of others as having equal normative standing. This claim allows us to revisit the conception of autonomy as key to distributed practical knowledge. While autonomy does not amount to self‐sufficiency and self‐reliance, it does demand independence of judgement and stands in contrast to servility, submission, and other sorts of defective ways of relying on others. The requirement of equal standing provides the basis for distinguishing between proper and improper reliance on others.
Chemotherapy‐induced diarrhoea in dogs and its management with smectite: Results of a monocentric open‐label randomized clinical trial
Authors: Fournier Quentin , Serra Juan‐Carlos , Williams Claire , Bavcar Spela 
Published: June 2020

AbstractChemotherapy‐induced diarrhoea (CID) is a frequent chemotherapy adverse event in dogs. Yet, there is currently no consensus regarding its management. Smectite is a natural medical clay, widely used in the treatment of acute diarrhoea in humans. The objectives of this study were to assess the efficacy of smectite in the management of CID in dogs, and to collect epidemiological data on CID. For each episode of diarrhoea, dogs were randomized into two management groups: Smectite group, receiving smectite at 0.5 g/kg PO per day divided in two to three doses initiated at the start of CID; control group, without initial medication. In both groups, rescue metronidazole was prescribed if CID progressed or was not improved within 48 hours. Sixty dogs were recruited and received 426 chemotherapy administrations between June 2017 and March 2019. The incidence rate of CID was 110/426 (25.8%, 95% CI: 21.7%‐30.2%), and significantly differed between the chemotherapeutic drugs administered (P < .001). Metronidazole was administered in 5/54 events (9.3%, 95% CI: 3.1%‐20.3%) in the smectite group and in 40/56 events (71.4%, 95% CI: 57.5%‐82.3%) in the control group (P < .001). The time to resolution of diarrhoea was shorter (P < .001) in the smectite group (median: 19.5 hours, interquartile range [IQR]: 13.5‐32 hours) compared with the control group (median: 53 hours, IQR: 31.5‐113.5 hours). The results of this study support the administration of smectite in the first‐line management of CID in dogs.
Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumours
Authors: Fabelo Carolina , Selmic Laura E. , Huang Pin‐Cheh , Samuelson Jonathan P. , Reagan Jennifer K. , Kalamaras Alexandra , Wavreille Vincent , Monroy Guillermo L. , Marjanovic Marina , Boppart Stephen A. 
Published: June 2020

AbstractOptical coherence tomography (OCT) uses near‐infrared light waves to generate real‐time, high‐resolution images on the microscopic scale similar to low power histopathology. Previous studies have demonstrated the use of OCT for real‐time surgical margin assessment for human breast cancer. The use of OCT for canine mammary tumours (CMT) could allow intra‐operative visualisation of residual tumour at the surgical margins. The purpose of this study was to assess OCT imaging for the detection of incomplete tumour resection following CMT surgery. We hypothesized that the OCT images would have comparable features to histopathological images of tissues at the surgical margins of CMT resections along with a high sensitivity of OCT detection of incomplete surgical excision of CMT. Thirty surgical specimens were obtained from nineteen client‐owned dogs undergoing surgical resection of CMT. OCT image appearance and characteristics of adipose tissue, skin, mammary tissue and mammary tumour at the surgical margins were distinct and different. The OCT images of normal and abnormal tissues at the surgical margins were utilized to develop a dataset of OCT images for observer evaluation. The sensitivity and specificity for ex vivo images were 83.3% and 82.0% (observer 1) and 70.0% and 67.9% (observer 2). The sensitivity and specificity for in vivo images were 70.0% and 89.3% (observer 1) and 76.7% and 67.9% (observer 2). These results indicate a potential use of OCT for surgical margin assessment for CMT to optimize surgical intervention and clinical outcomes. Improved training and experience of observers may improve sensitivity and specificity.
Molecular phylogeny and historical biogeography of the genus Platycerus (Coleoptera, Lucanidae) in East Asia
Authors: Zhu Xue‐Jiao , Ma Tao , Imura Yûki , Wen Xiu‐Jun , Kubota Kôhei 
Published: June 2020

AbstractThe genus Platycerus is a cool temperature zone taxon widely distributed in the Northern Hemisphere. In East Asia, 10, one and 28 species are known in Japan, Korea and China, respectively. Recent studies of Platycerus have revealed the divergence pattern in Japan and South Korea, but that of Chinese Platycerus is unknown. We conducted a phylogenetic and biogeographical study of Platycerus in East Asia, including China, using 68, 87 and 296 sequence data of the nuclear wingless gene, internal transcribed spacer (ITS) region and mitochondrial COI gene, respectively. Although the introgression of mitochondrial genes had been known in Japanese Platycerus, the essential contradiction was not recognized between the phylogenetic trees of nuclear genes and COI in Chinese Platycerus. In the COI tree, the Japanese clade and Asian continental clade diverged around 10.84 million years ago, and four major clades were recognized in the latter. For the shape of the posterolateral corner of the Platycerus pronotum, sharp (S)‐type species are distributed in higher latitudinal and lower altitudinal areas than round (R)‐type species in the Asian continent. S‐type species have evolved from R‐type species at least three times in more northerly areas, where the annual amplitude of temperature change is large. The genus Platycerus has been differentiated and speciated by a process unique to South Korea, Japan and China, according to regional topography. Thus, genetic differentiation and speciation in Platycerus are related to latitudinal and altitudinal gradients, as well as the site topographical profile and niche differentiation.
Strontium isotope dating of evaporites and the breakup of the Gulf of Mexico and Proto–Caribbean Seaway
Authors: Pindell James , Weber Bodo , Hale-Erlich Wendy , Cossey Stephen , Bitter Mark , Molina Garza Roberto , Graham Rod , Erlich Robert N. 
Published: June 2020

ABSTRACT
New and existing strontium isotope data are given for several widespread evaporites from western equatorial Pangea. The data indicate evaporite deposition occurred on proximal margins of the Gulf of Mexico at ca. 169 Ma (Bajocian, not Callovian as commonly thought) and 166 Ma in Trinidad (Bathonian-Callovian boundary). The 166 Ma age may also apply to undated evaporite on the Bahamian margin, conjugate rift of Trinidad, and now in Cuba. We show that: (1) the Trinidadian (and Bahamian?) evaporite pertains to rifting rather than to Late Jurassic–Cretaceous carbonate platform deposition; (2) the Mata Espino-101B evaporite (a borehole in Veracruz Basin, Mexico) is not Paleocene but Bajocian (halite) or Bathonian (gypsum) and hence is not related to possible Paleogene Gulf of Mexico desiccation; (3) evaporite deposition may have offlapped basinward in the Gulf of Mexico (Bathonian–early Oxfordian in more distal areas), because most Atlantic opening models preclude the Gulf of Mexico from being large enough by 169 Ma to accommodate the mapped expanse of autochthonous salt deposition; and (4) a 3–9 m.y. hiatus (the Norphlet window) is apparent in proximal areas around the Gulf of Mexico between evaporite and upper Oxfordian marine successions, caused perhaps by proximal margin uplift (flexural or thermal) or by Gulf of Mexico water level remaining below paleo–sea level (evaporation?) during Bathonian–early Oxfordian time. Although a 20–30 m.y. hiatus may exist below evaporite in the U.S. coast, cordilleran Mexico was tectonically active into the Middle Jurassic, and pre-salt continental deposits are closer in age to salt deposition there. Pre-salt strata along Campeche–northern Yucatán remain undated. Our data do not resolve if the evaporite was sourced from the Atlantic, the Pacific, or both, but the fact that the Trinidadian evaporite is younger than Gulf of Mexico evaporite, and the presence of Bajocian marine and evaporite sections across Mexico perhaps favor the Pacific as the source.
Triassic–Jurassic evolution of the eastern North China Craton: Insights from the Lushun-Dalian area, South Liaodong Peninsula, NE China
Authors: Ren Zhiheng , Lin Wei , Faure Michel , Meng Lingtong , Qiu Huabiao , Zeng Jipei 
Published: June 2020

AbstractThe Lushun-Dalian area of the South Liaodong Peninsula, in NE China, located in the SE margin of the North China Craton (NCC) exposes a suite of Middle-Late Proterozoic low-grade metamorphic sedimentary rocks which can be divided into a lower competent layer, a middle incompetent layer, and an upper competent layer on the basis of lithology and deformation style. Two stages of deformation recorded both in the metasedimentary rocks and a magmatic complex intruded in them indicate that the Lushun-Dalian area is a key region to decipher the Triassic–Jurassic tectonic evolution of the eastern NCC. The earliest D1 deformation mylonitized the magmatic complex and thrusted it northeastward over the low-grade metasedimentary rocks, in which a series of NE-verging folds and NE-directed brittle thrust faults developed. The D2 deformation erased the D1 fabrics in the incompetent layer by a top-to-the-NW ductile shearing and refolded the D1 fabrics in the lower and upper competent units, producing a series of km-scale SW-plunging folds. New zircon secondary ion mass spectrometry and laser ablation–inductively coupled plasma–mass spectrometry U-Pb ages from the magmatic complex and the granite porphyry dikes intruded in it, combined with the unconformity between the low-grade metasedimentary rocks and the Early Cretaceous volcanic rocks, indicate that D1 and D2 occurred after 211 Ma and before the Early Cretaceous. The decrease of the deformation intensity of D1 and D2 from the Lushun-Dalian area toward the interior of the NCC in the NE and NW directions suggests that D1 was the structural response in the overriding plate to the NCC-South China Block convergence during the Late Triassic to Early Jurassic, and D2 was the structural response to the northwestward subduction of the Paleo–Pacific plate beneath the NCC in the Middle-Late Jurassic. The superimposition of D2 on D1 recorded a significant tectonic transformation from the nearly E-W–trending Tethysian domain to the NE-SW–trending Pacific domain.
Characteristics of lung cancer in idiopathic pulmonary fibrosis with single lung transplant versus non-transplanted patients: a retrospective observational study
Authors: Gershman Evgeni , Zer Alona , Pertzov Barak , Shtraichman Osnat , Shitenberg Dorit , Heching Moshe , Rosengarten Dror , Kramer Mordechai 
Published: June 2020

BackgroundPatients with idiopathic pulmonary fibrosis (IPF) have significantly higher incidence of lung cancer (LC) relative to the general population. There is a further increase in LC incidence in patients with IPF subsequent to lung transplant, specifically in patients with IPF undergoing single lung transplant.ObjectivesTo examine the incidence and characteristics of LC in patients with IPF during follow-up and after lung transplantation (LTX).MethodsWe conducted a retrospective analysis of all patients with IPF diagnosed with LC in Rabin Medical Center, Israel, over an 11-year period. We compared the characteristics of transplanted patients with IPF diagnosed with LC to patients with IPF who did not undergo lung transplant. Data were accessed from database registries using the words ‘fibrosis’, ‘lung-cancer’ and ‘lung-transplantation’. Demographic parameters included age, gender and smoking history (pack years). Clinical-pathological parameters included lapse in time from IPF diagnosis to LC, type of malignancy, affected pulmonary lobe, and stage at diagnosis, oncological treatment and survival.ResultsBetween 2008 and 2018, 205 patients with IPF underwent lung transplantation at our medical centre. Double LTX was performed in 83 and single LTX in 122 cases. Subsequently, 15 (12.3%) single LTX patients were diagnosed with LC during the study period. During the same period, of 497 non-transplanted patients with IPF followed in our centre, 45 (9.1%) were diagnosed with LC. In all 15 transplanted patients with IPF, LC was diagnosed exclusively in the native fibrotic lung. LC incidence was higher in the transplanted as compared with the non-transplanted group, but this difference did not reach statistical significance (OR=0.7, 95% CI 0.38 to 1.32, p=0.28). At LC diagnosis, the non-transplanted group was older than the transplanted group with average age of 67.7 versus 60.8 years, respectively (p=0.006). Both groups showed male predominance. In both groups, LC was primarily peripheral, lower lobe predominant and most frequently squamous cell carcinoma. The median survival time after LC diagnosis was 4 months in the transplanted group and 11 months in the non-transplanted group (p=0.19). Multivariate analysis showed improved survival in the non-transplanted group among those patients who received oncological treatment.ConclusionChest CT should be performed regularly in order to evaluate IPF patients for potential LC. Single lung transplant IPF patients face an increased risk of post-transplant LC in the native fibrotic lung. Where practicable, IPF patients should be prioritised for double lung transplant.
Unnecessary wait hours: a novel ED system-level metric
Authors: Heaton Heather A , Nestler David M , Pasupathy Kalyan S , Wutthisirisart Phichet , Sir Mustafa Y , Hellmich Thomas R 
Published: June 2020

BackgroundEmergency department (ED) operations leaders are under increasing pressure to make care delivery more efficient. Publicly reported ED efficiency metrics are traditionally patient centred and do not show situational or facility-based improvement opportunities. We propose the consideration of a novel metric, the ‘Number of Unnecessary Waits (NUW)’ and the corresponding ‘Unnecessary Wait Hours (UWH)’, to measure space efficiency, and we describe how we used NUW to evaluate operational changes in our ED.MethodsUWH summarises the relationship between the number of available rooms and the number of patients waiting by returning a value equal to the number of unnecessary patient waits. We used this metric to evaluate reassigning a clinical technician assistant (CTA) to the new role of flow CTA.ResultsWe retrospectively analysed 3.5 months of data from before and after creation of the flow CTA. NUW metric analysis suggested that the flow CTA decreased the amount of unnecessary wait hours, while higher patient volumes had the opposite effect.ConclusionsSituational system-level metrics may provide a new dimension to evaluating ED operational efficiencies. Studies focussed on system-level metrics to evaluate an ED practice are needed to understand the role these metrics play in evaluation of a department’s operations.
Naturally occurring 5′ preS1 deletions markedly enhance replication and infectivity
of HBV genotype B and genotype C
Authors: Li Jing , Li Jisu , Chen Shiqi , Yuan Quan , Zhang Jing , Wu Jingwen , Jiang Qirong , Wang Qianru , Xia Ning-Shao , Zhang Jiming , Tong Shuping 
Published: June 2020

Background and aims
Deletion of 15-nucleotide or 18-nucleotide (nt) covering preS1 ATG frequently
arises during chronic infection with HBV genotypes B and C. Since the second ATG is
33nt downstream, they truncate large (L) envelope protein by 11 residues like
wild-type genotype D. This study characterised their functional consequences.

Methods
HBV genomes with or without deletion were amplified from a patient with advanced
liver fibrosis and assembled into replication competent 1.1mer construct. Deletion,
insertion or point mutation was introduced to additional clones of different
genotypes. Viral particles concentrated from transfected HepG2 cells were inoculated
to sodium taurocholate cotransporting polypeptide (NTCP)-reconstituted HepG2
(HepG2/NTCP) cells or differentiated HepaRG cells, and HBV RNA, DNA, proteins were
monitored.

Results
From transfected HepG2 cells, the 15-nt and 18-nt deletions increased HBV RNA,
replicative DNA and extracellular virions. When same number of viral particles was
inoculated to HepG2/NTCP cells, the deletion mutants showed higher infectivity.
Conversely, HBV infectivity was diminished by putting back the 18nt into naturally
occurring genotype C deletion mutants and by adding 33nt to genotype D. Infectivity of
full-length genotype C clones was also enhanced by mutating the first ATG codon of the
preS1 region but diminished by mutating the second in-frame ATG. Removing N-terminal
11 residues from preS1 peptide 2–59 of genotype C potentiated inhibition of HBV
infection and enhanced binding to HepG2/NTCP cells.

Conclusions
The 15-nt and 18-nt deletions somehow increase HBV RNA, replicative DNA and
virion production. Shortened L protein is more efficient at mediating HBV
infection.