bluuebunny/crossref_metadata_2025_split huggingface dataset:
A database resource and online analysis tools for coronaviruses on a historical and global scale
Authors: Zhu Zhenglin , Meng Kaiwen , Liu Gexin , Meng Geng 
Published: July 2020

AbstractThe recent outbreak of COVID-19 caused by a new zoonotic origin coronavirus (SARS-CoV-2 or 2019-nCoV) has sound the alarm for the potential spread of epidemic coronavirus crossing species. With the urgent needs to assist disease control and to provide invaluable scientific information, we developed the coronavirus database (CoVdb), an online genomic, proteomic and evolutionary analysis platform. CoVdb has brought together genomes of more than 5000 coronavirus strains, which were collected from 1941 to 2020, in more than 60 countries and in hosts belonging to more than 30 species, ranging from fish to human. CoVdb presents comprehensive genomic information, such as gene function, subcellular localization, topology and protein structure. To facilitate coronavirus research, CoVdb also provides flexible search approaches and online tools to view and analyze protein structure, to perform multiple alignments, to automatically build phylogenetic trees and to carry on evolutionary analyses. CoVdb can be accessed freely at http://covdb.popgenetics.net. Hopefully, it will accelerate the progress to develop medicines or vaccines to control the pandemic of COVID-19.
Fifty-one years with an aortic valve prosthesis despite suboptimal anticoagulation: half a century with the Smeloff-Cutter valve
Authors: Tripodi Vincenzo F , Covino Angelo , Fratto Pasquale , Benedetto Frank A 
Published: July 2020

Abstract
This case report describes an unusual case of a 69-year-old man who had an aortic valve replacement with the Smeloff-Cutter aortic mechanical prosthesis for aortic valve regurgitation at the age of 18 years. Echocardiography revealed a well-suited and well-functioning mechanical prosthesis. Even though the patient did not take any anticoagulant therapy or anti-platelets agent for 12 years, he was in surprisingly good health. To the best of our knowledge, this is the first time a mechanical ‘ball-in-cage’ valve prosthesis has lasted for such a long time without complications, although the patient has not been compliant with the anticoagulant therapy for 12 consecutive years.
Assessment tool validation and technical skill improvement in the simulation of the Norwood operation using three-dimensional-printed heart models
Authors: Hussein Nabil , Honjo Osami , Barron David J , Haller Christoph , Coles John G , Van Arsdell Glen , Lim Andrew , Yoo Shi-Joon 
Published: July 2020

Abstract

OBJECTIVES
The hands-on surgical training course utilizes 3-dimensional (3D)-printed heart models to simulate complex congenital heart operations. This study aimed to validate a model and assessment tool in the simulation of 2 techniques of the Norwood operation and investigate whether technical performance improves following rehearsal with or without proctor presence.

METHODS
Five ‘experienced’ and 5 ‘junior’ surgeons performed 2 techniques of the Norwood operation on 3D-printed models of hypoplastic left heart syndrome. Performances were retrospectively assessed by 10 raters with varying experience in congenital heart surgery (CHS) (Medical Doctorate versus non-Medical Doctorate). Assessments were made with the procedure-specific Hands-On Surgical Training-CHS tool. Results were analysed for technical performance and rater consistency. Following validation, 30 surgeons (24 with proctor guidance and 6 with training videos and objective feedback only) simulated the Norwood operation twice.

RESULTS
Performance scores were consistently higher for experienced surgeons and raters discriminated clearly between the experienced and junior surgeons (P ≤ 0.001). The hands-on surgical training-CHS tool showed high inter-rater (0.86) and intra-rater (0.80) reliability among all raters. Scores for both experienced and junior surgeons were highly consistent across all raters, with no statistically significant difference (P = 0.50). All surgeons successfully performed the Norwood operation. Sixty attempts were scored in total. Eighty-seven percentage (26/30) of surgeons’ scores (mean: attempt 1 = 92, attempt 2 = 104) and times [mean: attempt 1 = 1:22:00, attempt 2 = 1:08:00 (h:mm:ss)] improved between the 2 attempts by 9% and 15% respectively (P ≤ 0.001). Total scores of all surgeons in the non-proctored subgroup (6) improved by 15% on average (mean: attempt 1 = 86, attempt 2 = 105, P = 0.002).

CONCLUSIONS
Procedure-specific assessment tools can be developed to evaluate technical performance for complex CHS simulation and be performed reliably by non-expert raters. Rehearsal both under supervision and independently leads to technical skill improvement further supporting its value in CHS training.
Diagonal Export Controls to Counter Diagonal Transnational Attacks on Civil Society
Authors: Lin Herbert , Trachtman Joel 
Published: July 2020

Abstract
Modern geopolitics includes measures short of armed conflict designed to control decision-making in, and action by, target states. One increasingly significant category of these measures involves attacks by foreign states against civil society institutions in target states. Liberal states that seek to protect their civil societies from this interference seek to bolster civil society defences, to determine the origin of and respond to attacks and to deny relevant tools to potential attackers. With the rise of cyberspace, target states using purely territorial measures are increasingly impotent to protect their civil societies from foreign governmental hacking. Denying access to advanced hacking software by antagonist foreign states may assist in protecting target state civil societies. This article explores the possibility of denying hacking tools to potential attackers, identifies some of the problems and proposes a refinement of export controls that will permit greater protection with less disruption of desirable software development.
Should we still offer elective freezing of all embryos in all IVF cycles?
Authors: Ben Rafael Zion 
Published: July 2020

ABSTRACT
Elective ‘freeze all’, also called ‘freeze only’, refers to an IVF cycle where all embryos are frozen for later embryo transfer in a non-stimulated cycle, with the promise of increased success rates and prevention of ovarian hyperstimulation syndrome (OHSS) in most patients. However, ‘freeze all’ is associated with significantly higher perinatal complications including eclampsia, preeclampsia, chronic hypertension and large-for-gestational-age infants, without the demonstrated advantages of providing better results, except for a decrease in the incidence of OHSS, which should matter to women with polycystic ovary syndrome (PCOS) and high responders to ovarian stimulation but not to all patients. ‘Freeze all’ is also suggested for all simulated IVF cycles, due to the alleged ‘faulty endometrium’ caused by ovarian stimulation. However, there is no direct evidence that asynchronous endometrium exists, and only if preovulatory progesterone level increase, can ‘freeze all’ confer an advantage. We conclude that an alleged diagnosis of ‘faulty endometrium’ should not be used as an indication for ‘freeze all’. To offset the risk of OHSS more simply, less costly and less risky solutions such as mild ovarian stimulation, to dampen the number of oocytes and to aim for transfer of a single blastocyst, should be the preferred solution to treat women with PCOS and high responders for oocyte retrieval.
Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells
Authors: Hui Qianru , Ammeter Emily , Liu Shangxi , Yang Runqiang , Lu Peng , Lahaye Ludovic , Yang Chengbo 
Published: July 2020

Abstract
Eugenol (4-allyl-2-methoxyphenol) is an essential oil component, possessing antimicrobial, anti-inflammatory, and antioxidative properties; however, the effect of eugenol on porcine gut inflammation has not yet been investigated. In this study, an in vitro lipopolysaccharide (LPS)-induced inflammation model in porcine intestinal epithelial cells (IPEC-J2) has been set up. Cells were pretreated with 100 μM (16.42 mg/L) eugenol for 2 h followed by 10 μg/mL LPS stimulation for 6 h. Proinflammatory cytokine secretion; reactive oxygen species; gene expression of proinflammatory cytokines, tight junction proteins, and nutrient transporters; the expression and distribution of zonula occludens-1 (ZO-1); transepithelial electrical resistance (TEER); and cell permeability were measured to investigate the effect of eugenol on inflammatory responses and gut barrier function. The results showed that eugenol pretreatment significantly suppressed the LPS-stimulated interleukin-8 level and the mRNA abundance of tumor necrosis factor-α and restored the LPS-stimulated decrease of the mRNA abundance of tight junction proteins, such as ZO-1 and occludin, and the mRNA abundance of nutrient transporters, such as B0 1 system ASC sodium-dependent neutral amino acid exchanger 2, sodium-dependent glucose transporter 1, excitatory amino acid transporter 1, and peptide transporter 1. In addition, eugenol improved the expression and even redistribution of ZO-1 and tended to increase TEER value and maintained the barrier integrity. In conclusion, a low dose of eugenol attenuated inflammatory responses and enhanced selectively permeable barrier function during LPS-induced inflammation in the IPEC-J2 cell line.
Amphipods and sea anemones, an update
Authors: Vader Wim , Tandberg Anne Helene S 
Published: July 2020

AbstractWe present an updated survey of the Amphipoda that live in association with sea anemones. These amphipods can be divided into four groups: 1) symbiotic amphipods using sea anemones mainly for protection, but feeding largely independently; 2) amphipods feeding on sea anemones, but not permanently associated; 3) symbiotic amphipods living permanently among the tentacles of the sea anemones; and 4) symbiotic amphipods living permanently in the gastrovascular cavity of the sea anemones. Contrary to previous speculations, it appears that the amphipods in groups 3 and 4 mainly feed on host tissue, and the anemone-eating amphipods can therefore generally be classified as micropredators (group 2), ectoparasites (group 3), and almost endoparasites (especially those species in group 4 that spend their entire life cycle inside their hosts).Although the associates in the latter two groups show various minor morphological, reproductive, and physiological adaptations to the symbiosis, these associations evolved many times independently. We provide new information on feeding ecology and a discussion of the evolution of these associations.
A model-theoretic approach to descriptive general frames: the van Benthem characterization theorem
Authors: Bezhanishvili Nick , Henke Tim 
Published: July 2020

AbstractThe celebrated van Benthem characterization theorem states that on Kripke structures modal logic is the bisimulation-invariant fragment of first-order logic. In this paper, we prove an analogue of the van Benthem characterization theorem for models based on descriptive general frames. This is an important class of general frames for which every modal logic is complete. These frames can be represented as Stone spaces equipped with a ‘continuous’ binary relation. The proof of our theorem generalizes Rosen’s proof of the van Benthem theorem for finite frames and uses as an essential technique a new notion of descriptive unravelling. We also develop a basic model theory for descriptive general frames and show that in many ways it behaves like the model theory of finite structures. In particular, we prove the failure of the compactness theorem, of the Beth definability theorem, of the Craig interpolation theorem and of the upward Löwenheim–Skolem theorem.1
COVID-19 and the financial system: a tale of two crises
Authors: Giese Julia , Haldane Andy 
Published: July 2020

Abstract
This paper compares and contrasts the resilience of the financial system, in particular banks, during the Global Financial Crisis and COVID-19. We show that banks are now part of the solution, rather than part of the problem, thanks to regulatory and institutional reforms over the past decade. Heeding the lessons from the Global Financial Crisis has paid dividends. We outline some early lessons from the COVID-19 crisis for the financial system going forward.
The Early-Life Origins of Later-Life Networks
Authors: Goldman Alyssa W 
Published: July 2020

AbstractPersonal social networks profoundly influence a wide range of outcomes throughout the life course. But little research has considered how some features of individuals’ social networks may be shaped by experiences in early life. This study uses nationally representative data from the National Social Life, Health, and Aging Project to examine how childhood circumstances may shape the structure of older adults’ personal social networks. The analyses show that higher childhood socioeconomic status is associated with larger network size and a more expansive, less kin-based network structure. At the same time, higher levels of family happiness in childhood are associated with greater network density and more kin-centric network composition, which may reflect greater access to social support and overall network intimacy across the life course. The results suggest that studies of the relative advantages of social network structure may benefit from contextualizing individuals’ social networks in terms of their social origins. The article discusses the need for additional research on the life-course bases of the link between childhood circumstances and later-life network properties, and what role this connection plays in shaping later-life well-being.
Trustworthiness: a dialectical perspective
Authors: Kumar Senthil 
Published: July 2020

Abstract
Trustworthiness is the core feature of the most productive and effective organizations. While the market value of an economic or business entity would mostly correspond to its trust-equity, however, an erosion of trust-equity will cause the market-value to nose dive. Studies have demonstrated that the ‘distrust’ or a ‘lack of trustworthiness’ can cost a business or government billions of dollars. Lack of trust within an organization can result in employee disengagement and organizational atrophy. An untrustworthy organization will not only alienate its employees, it will also cause damage to customer interests. In this article, we postulate how trustworthiness can act as a dialectical fulcrum between the diametrically opposing market/social forces within an economic/political organization—such as self-interest versus public good, cooperation versus competition, freedom versus control, labor versus capital, and production versus consumption.
Relocating IV Pumps for Critically Ill Isolated Coronavirus Disease 2019 Patients From Bedside to Outside the Patient Room
Authors: Shah Ami G. , Taduran Chris , Friedman Seana , Sarosky Kimberly , Jones Mila , Victory-Stewart Marcelina , Dunau Frederick , Liesenfeld Meghan , Pasqualini Darla , Mandel Sarah , Fiol Natalie , Ghia Samit , Puskas John D. , Bhatt Himani V. , Shapiro Janet , Tomey Matthew I. , Yimen Mekeleya 
Published: July 2020

Objectives:
Discuss advantages and disadvantages of relocating IV pumps for coronavirus disease 2019 patients from bedside to outside the patient room and characterize reproducible details of an external infusion pump model.

Design:
Brief report.

Setting:
ICUs at a single-center teaching hospital.

Patients:
Critically ill coronavirus disease 2019 patients under contact and special droplet precautions.

Interventions:
Relocation of IV pumps for coronavirus disease 2019 patients from bedside to outside the patient room using extension tubing.

Measurements and Main Results:
Infusion pumps secured to a rolling IV pole are moved immediately outside the patient room with extension tubing, reaching the patient through a closed door. It is anticipated that this practice may reduce unnecessary coronavirus disease 2019 exposure for healthcare professionals, reduce the consumption of personal protective equipment, and promote patient safety by limiting delays of donning personal protective equipment to initiate or adjust medications.

Conclusions:
Risks of situating IV pumps outside the patient room must be carefully weighed against the benefits. Relocation of IV pumps outside the patient room may be considered given shortages of personal protective equipment and high risk of healthcare professional exposure. Institutional review-approved studies investigating the measured impact on decreased exposure, personal protective equipment usage, and patient safety are required.
Long-term Renal Outcomes in Adults With Sepsis-Induced Acute Kidney Injury
Authors: Harris Pamela L. , Umberger Reba A. 
Published: July 2020

Background
Despite advances in medical technologies and intervention occurrences, acute kidney injury (AKI) incidence continues to rise. Early interventions after sepsis are essential to prevent AKI and its long-term consequences. Acute kidney injury is the leading cause of organ failure in sepsis; therefore, more research is needed on its long-term consequences and progression to kidney injury.

Objectives
The aim of this study was to review the state of the science on long-term renal outcomes after sepsis-induced AKI and long-term renal consequences.

Methods
We identified research articles from PubMed and CINAHL databases using relevant key words for sepsis-induced AKI within 5 years delimited to full-text articles in English.

Results
Among 1280 abstracts identified, we ultimately analyzed 12 full-text articles, identifying four common themes in the literature: (1) AKI determination criteria, (2) severity/prognosis-related factors, (3) time frame for long-term outcome measures, and (4) chronic kidney disease (CKD) and renal related exclusions. Researchers primarily used KDIGO (Kidney Disease: Improving Global Outcomes) guidelines to define AKI. All of these studies excluded patients with CKD. The range of time for long-term renal outcomes was 28 days to 3 years, with the majority being 1 year. Renal outcomes ranged from recovery to renal replacement therapy to death.

Conclusions
To better understand the long-term renal outcomes after sepsis-induced AKI, more consistent measures are needed across all studies regarding the time frame and specific renal outcomes. Because all of these articles excluded patients with CKD, a gap exists on long-term renal outcome in acute on CKD.
Do Illness Perception Predict Perceived Learning Needs Among Patients Treated With Percutaneous Coronary Intervention
Authors: Ashour Ala , Al-Smadi Ahmed , Tawalbeh Loai , Alshraifeen Ali , Al-Rawashdeh Sami , Gharaibeh Besher 
Published: July 2020

Background
The number of coronary heart disease (CHD) patients treated with percutaneous coronary intervention (PCI) has increased. The illness perception (IP) of PCI recipients needs to be evaluated. Yet, little is known whether patients' IP predicts perceived learning needs among patients treated with PCI.

Objective
The aim of this study was to assess patients' IP and to examine its influence on perceived learning needs post PCI.

Methods
A cross-sectional design was used. A convenience sample of 208 patients who had undergone first-time PCI participated in the study. Data were collected before patients were discharged from the hospital using the Brief Illness Perception Questionnaire and the Percutaneous Coronary Intervention Learning Need Scale.

Results
Patients were highly concerned about their illness and perceived high consequences and symptoms related to CHD. They perceived low levels of personal and treatment control over their illness. Patients reported high learning needs. Multiple linear regression showed that low perception of personal control (P < .037), treatment control (P < .041), and high perception of disease symptoms (P < .018) significantly predicted high perceived learning needs.

Conclusion
Hence, the patients' IP influences perceived learning needs, which may be included in routine clinical assessments. Tailored health education programs are needed for patients treated with PCI; such a program should target patients who perceived low levels of personal and treatment control over illness and have a high perception of symptoms.
Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants
Authors: López Eduardo Luis , Ferolla Fausto Martin , Toledano Analía , Yfran Eduardo Walter , Giordano Ana Clara , Carrizo Bárbara , Feldman Florencia , Talarico Laura Beatriz , Caratozzolo Ana , Contrini María Marta , Acosta Patricio Leandro 
Published: July 2020

Background:
Genetic background may be an important host determinant of respiratory syncytial virus (RSV) disease severity, but full characterization of susceptibility genes remains unclear. This study aimed to assess the presence of specific single-nucleotide polymorphisms (SNPs) in selected genes codifying for different components of the antiviral innate immune response, to determine their role for developing RSV life-threatening disease (LTD).

Methods:
Prospective cohort study including previously healthy full-term infants hospitalized with a first RSV infection during 2017–2018. RSV detection, quantification and subgroup determination, and genotyping for SNPs in Toll-like receptor 4 (TLR4 rs4986790, rs4986791), Toll-like receptor 8 (TLR8 rs3761624), macrophage receptor with collagenous structure(MARCO rs1318645) and myxovirus resistance 1(MX1 rs469390) were performed by real-time polymerase chain reaction in nasopharyngeal aspirates obtained on admission. Patients with LTD were those admitted to the intensive care unit requiring ventilatory support.

Results:
Seventy-five patients were studied, 15 (20%) developed LTD. Infants with concurrent SNPs in MX1 and TLR8, MARCO and TLR8 or MARCO, MX1 and TLR8 had an increased risk of developing LTD. Multivariable logistic regression analysis confirmed this significant association (odds ratio [OR] = 3.75, P = 0.046; OR = 3.92, P = 0.040; OR = 5.56, P = 0.010, respectively). No differences were seen in viral load of patients with LTD compared with those with better outcome (P = 0.737). In addition, no differences in viral load were seen in patients with the described high-risk SNPs compared with those without these polymorphisms.

Conclusions:
Life-threatening RSV infection in previously healthy infants was significantly associated with the presence of combined SNPs in MARCO, MX1 and TLR8.