bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cross‐sectional study of hepatic lipase SNPs and plasma lipid levels
Authors: Wei Wang , Hu Tian , Luo Huilong , Ye Zhang , Lu Feiteng , Wu Yanqing , Ying Muying 
Published: January 2020

AbstractBy the combination of meta‐analysis, the data of the 1,000 Genomes Project Phase 3, and the promoter sequence of hepatic lipase (LIPC), we performed the cross‐sectional study to explore the associations of four variants (rs1077835; rs1077834; rs1800588 [C‐514T], and rs2070895 [G‐250A]) in LIPC promoter with plasma lipid levels. Our results indicate that the first and the next three of the four SNPs are, respectively, reported to be associated with the decreased and increased HDL‐c level. Meta‐analysis of 87 studies with 101,988 participants indicates that HDL‐c level in rs1800588 (C‐514T) (pooled mean difference = 0.03, 95%CI (0.03, 0.04), p < .001) and rs2070895 (G‐250A) (pooled mean difference = 0.07, 95%CI (0.05, 0.09), p < .001) is higher in allele T or A carriers. Similarly, LDL‐c, TC, TG, and BMI levels are generally increased in T or A alleles carriers. We failed to conduct the meta‐analysis of rs1077835 and rs1077834 due to the limited previous reports. Data from the 1,000 Genomes indicate that the allele frequencies of the four SNPs in total or subpopulations are almost equal to each other. The paired value r2 and D' of the four SNPs are larger than 0.8, which indicate the linkage disequilibrium of the four variants. The analysis of LIPC promoter indicate that C‐514T and G‐250A are, respectively, located in transcriptional factor binding sites of USF1and Pbx1b, which may partly explain the effect of the two SNPs on the decreased LIPC activity in the alleles carriers and the corresponding increased plasma lipids hydrolyzed by LIPC. These results may help us to better understand the different effects of the four SNPs on the plasma lipid levels among subpopulations and offer clues for future clinical treatment of dyslipidemia‐related diseases.
Rehabilitation and reintegration programming adjunct to female genital fistula surgery: A systematic scoping review
Authors: El Ayadi Alison M. , Painter Caitlyn E. , Delamou Alexandre , Barr‐Walker Jill , Korn Abner , Obore Susan , Byamugisha Josaphat , Barageine Justus K. 
Published: January 2020

AbstractBackgroundFemale genital fistula is associated with significant physical, psychological, and economic consequences; however, a knowledge and practice gap exists around services adjunct to fistula surgery.ObjectivesTo examine rehabilitation and reintegration services provided adjunct to genital fistula surgery, map existing programming and outcomes, and identify areas for additional research.Search strategyWe searched the published and grey literature from January 2000 to June 2019. Two reviewers screened articles and extracted data using standardized methods.Selection criteriaResearch and programmatic articles describing service provision in addition to female genital fistula surgery were included.Data collection and analysisOf 3047 published articles and 2623 unpublished documents identified, 26 and 55, respectively, were analyzed.Main resultsProgramming identified included combinations of health education, physical therapy, social support, psychosocial counseling, and economic empowerment, largely in sub‐Saharan Africa. Improvements were noted in physical and psychosocial health.ConclusionsExisting literature supports holistic fistula care through adjunct reintegration programming. Improving the evidence base requires implementing robust study designs, increasing reporting detail, and standardizing outcomes across studies. Increased financing for holistic fistula care is critical for developing and supporting programming to ensure positive outcomes.
Formation of a calcium oxalate urethral stone in a 3‐year‐old boy due to hypocitraturia
Authors: Kita Nobuhisa , Nagao Yoshiro , Nabeshima Yoshiyuki , Yamane Ichiro , Hirata Masaaki , Hatakeyama Kuniya 
Published: January 2020

IntroductionUrolithiasis in children is often due to metabolic abnormalities (e.g. hypocitraturia) and hence recurs frequently.Case presentationA 3‐year‐old boy presented with gross hematuria. Computed tomography detected a urethral calculus. The calculus was removed surgically. The stone was composed of calcium oxalate. Although oxalate and uric acid levels in the urine were within normal ranges, urine calcium was moderately elevated and urine citrate was substantially low. Urinalyses of the parents revealed that the father had acidic hypocitraturic urine, containing oxalate crystals, and the mother had hypercalciuria. Administration of oral citrate acid normalized urine citrate levels and eliminated the oxalate crystals, from the boy and his father.ConclusionAlthough preventing urolithiasis using oral citrate is common in the adult population, this preventive measure is not well recognized in children, thus warranting further study.
Platelet‐rich fibrin prevents postoperative intestinal adhesion
Authors: Wang Jia , Le Kai , Guo Xu , Yan Fengcai , Guo Yifan , Zhang Tao , Ren Yu , Zhang Jianlu , Zhu Bin 
Published: January 2020

AbstractPlatelet‐rich fibrin (PRF) was prepared from the blood of BALB/C inbred mice to explore potential effects on postoperative intestinal adhesion. A murine model of intestinal adhesion characterized by abdominal wall defect/and cecum damage was established by scraping caecum serosa and cutting peritoneum and muscles in the abdominal wall. The wound was covered with PRF (group A), sodium hyaluronate (group B), or left alone (blank control; group C). All animals were monitored for 28 days. The incidence of adhesion was 35.0, 66.7, and 73.7% in groups A, B, and C, respectively. The incidence of adhesion in group A was significantly lower than that in group C (p < .05). Histopathologically, severity of fibrosis and the number of fibroblasts or inflammatory cells in group A were lower than those in groups B and C (p < .05), whereas the number of mesothelial cells was higher (p = .001). Furthermore, the severity of fibrosis and number of fibroblasts or inflammatory cells were lower in low grade than those in high grade of adhesion (p < .05), whereas the number of mesothelial cells was higher (p < .05). Collectively, PRF applied to abdominal surgery may reduce the incidence of intestinal adhesion by promoting proliferation of mesothelial cells whereas inhibiting proliferation of fibroblasts and infiltration of inflammatory cells.
EGCG regulates CTR1 expression through its pro‐oxidative property in non‐small‐cell lung cancer cells
Authors: Chen Aochang , Jiang Pan , Zeb Falak , Wu Xiaoyue , Xu Chuyue , Chen Lijun , Feng Qing 
Published: January 2020

AbstractCopper transporter 1 (CTR1) plays an important role in increasing cisplatin intake. Our previous studies showed that CTR1 expression was upregulated by (−)‐epigallocatechin‐3‐gallate (EGCG), a green tea polyphenol, therefore enhanced cisplatin sensitivity in ovary cancer and non‐small‐cell lung cancer (NSCLC) cells. In the current study in the non‐small‐cell lung cancer cells, we uncovered a potential mechanism of EGCG‐induced CTR1 through its pro‐oxidative property. We found that EGCG increased reactive oxygen species (ROS) generation, while in the presence of ROS scavenger N‐acetyl‐cysteine (NAC), ROS production was eliminated. Changes of CTR1 expression were consistent with the ROS level. Simultaneously, EGCG downregulated ERK1/2 while upregulated lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) through ROS to induce CTR1 expression. Besides, in a nude mouse xenografts model, EGCG treatment raised ROS level, expression of CTR1 and NEAT1 in tumor tissue. Also, ERK1/2 and p‐ERK1/2 were suppressed as well. Taken together, these results suggested a novel mechanism that EGCG mediated ROS to regulate CTR1 expression through the ERK1/2/NEAT1 signaling pathway, which provided more possibilities for EGCG as a natural agent in adjuvant therapy of lung cancer.
Combining field phosphorus runoff risk assessments with whole‐farm phosphorus balances to guide manure management decisions
Authors: Ros Mart B.H. , Czymmek Karl J. , Ketterings Quirine M. 
Published: January 2020

AbstractPhosphorus (P) loss from agricultural fields contributes to water quality degradation. A phosphorus index (PI) is a tool that scores fields based on P loss potential. Recently, a new transport × best or beneficial management practice (BMP) approach was proposed for the New York PI (NY‐PI), which first scores fields using landscape‐based transport factors (raw scores) and then offers various BMPs to reduce the score (i.e., risk of P transport). The final score is assigned a management implication (N needs based, P removal based, or zero P application), taking into account field‐specific soil‐test P (STP) and the farm's whole‐farm P balance. With farmer and nutrient management planner input and data on field‐specific transport factors and whole‐farm P balances of 18 New York dairy farms, we set coefficients for transport factors, BMPs related to P application, and STP limits and determined the impact of implementation of the new NY‐PI on manure management options. Based on raw scores, the proposed NY‐PI initially limited manure application to 51% of the total cropland area of the participating farms (28% N‐based, 23% P‐based). Implementation of BMPs (i.e., changing the method and ground cover or timing of P application) allowed 43–98% of the land area to receive manure at N‐based rates. For farms with whole‐farm P balances within the feasible limits set for New York, an additional 0–50% of the land base was classified as N‐based management, depending on BMP selection. These results show the ability of the new NY‐PI to limit P applications on fields with high transport risk while incentivizing adoption of BMPs and improvements in whole‐farm P management.
A novel catalyst‐free mechanochemical protocol for the synthesis of 2,3‐dihydro‐1H‐perimidines
Authors: Harry Nissy Ann , Radhika Sankaran , Neetha Mohan , Anilkumar Gopinathan 
Published: January 2020

AbstractA rapid, efficient, and green grinding assisted method for the synthesis of 2,3‐dihydro‐1H‐perimidines has been developed. 1,8‐Diaminonaphthalene and aldehydes were ground using mortar and pestle for 5 minutes affording the product in moderate to excellent yields. The methodology minimises the use of conventional workup and column chromatographic techniques.
MRI vs. CT for the Detection of Liver Metastases in Patients With Pancreatic Carcinoma: A Comparative Diagnostic Test Accuracy Systematic Review and Meta‐Analysis
Authors: Alabousi Mostafa , McInnes Matthew DF , Salameh Jean‐Paul , Satkunasingham Janakan , Kagoma Yoan K. , Ruo Leyo , Meyers Brandon M. , Aziz Tariq , van der Pol Christian B. 
Published: January 2020

BackgroundThe detection of liver metastases is important for pancreatic cancer curative treatment eligibility. The data suggest that magnetic resonance imaging (MRI) is more sensitive than computed tomography (CT) for the diagnosis of pancreatic cancer liver metastases. However, MRI is not currently recommended in multiple published guidelines.PurposeTo perform a comparative diagnostic test accuracy systematic review and meta‐analysis comparing CT and MRI for pancreatic cancer liver metastases detection.Study TypeSystematic review and meta‐analysis.Data SourcesMEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and multiple radiology society meeting archives were searched until November 2018. Comparative design studies reporting on liver CT and MRI accuracy for detection of pancreatic cancer liver metastases in the same cohort were included.Field Strength1.5T or 3.0T.AssessmentDemographic, methodologic, and diagnostic test accuracy data were extracted. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)‐2 tool.Statistical TestsAccuracy metrics were obtained using bivariate random‐effects meta‐analysis. The impact of different covariates on accuracy estimates was assessed using a meta‐regression model. Covariates included modality, study design, tumor characteristics, risk of bias, and imaging protocols.ResultsFourteen studies including 987 patients with pancreatic cancer (205 with liver metastases) were included. Sensitivity for CT and MRI was 45% (confidence intervals [95% CI] 21–71%) and 83% (95% CI 74–88%), respectively. Specificity for CT and MRI was 94% (95% CI 84–98%) and 96% (95% CI 93–97%), respectively. The greater observed sensitivity of MRI was preserved in the meta‐regression model (P = 0.01), while no difference in specificity was detected (P = 0.16). CT sensitivity was highest for triphasic and quadriphasic examinations compared to single phase or biphasic protocols (P = 0.03). Most studies were at high risk of bias.Data ConclusionMRI is more sensitive than CT for pancreatic cancer liver metastases detection, accounting for confounding variables. Consideration of this finding in clinical practice guidelines is recommended.Level of Evidence3Technical Efficacy Stage3
Influence of anionic, neutral, and cationic polysaccharides on the in vitro digestibility of raw and gelatinized potato starch
Authors: Sasaki Tomoko 
Published: January 2020

AbstractBACKGROUNDPolysaccharides have been expected to have a suppressive effect on starch digestibility by blending. The objective of this study was to investigate the effects of anionic (xanthan gum), neutral (guar gum), and cationic (chitosan) polysaccharides on the in vitro digestibility of raw and gelatinized starch using six potato cultivars differing in phosphorus content.RESULTSBy comparing the starch digestibility between potato cultivars, a significant difference was observed for the raw starches, and ‘Benimaru’, which is a potato cultivar containing a higher proportion of short‐chain amylopectin and the lowest phosphorus content in starch, showed a distinctly faster rate of starch hydrolysis. The added polysaccharides decreased the extent of digestion of both raw and gelatinized starches. No significant correlation between phosphorus content and the extent of starch digestion was observed in mixed systems, whereas significant correlations were noted between the extent of starch digestion and Rapid Visco Analyser parameters. The extent of raw and gelatinized starch digestion negatively correlated with pasting temperature, initial viscosity before heating, and peak viscosity (P < 0.01).CONCLUSIONThe added polysaccharides were observed to decrease the starch digestibility, and their suppressive effects were mainly dependent on the increase of viscosity rather than chemical interactions. A combination of potato cultivar and type of polysaccharide was proved to be important for nutritional value of potato starch. © 2020 Society of Chemical Industry
Enrichment of food blends with bambara groundnut flour: Past, present, and future trends
Authors: Nwadi Oluchukwu M.M. , Uchegbu Nneka , Oyeyinka Samson A. 
Published: January 2020

AbstractThe aim of this paper was to review the literature (1993 to 2019) on the protein content and use of bambara groundnut in processed foods to improve nutritional value. Bambara groundnut is a legume, which is rich in protein. The protein content of bambara groundnut may vary with cultivar, growing conditions, and location as well as processing method. Complementary foods have been formulated with bambara groundnut as an ingredient. Bambara groundnut has also been used in many other food formulations and this has improved the protein content of such foods. Most of the food products containing high quantity of bambara groundnut despite the high protein content are not acceptable based on sensory evaluation especially taste and flavour. Some researchers have attempted to improve on the sensory properties of products containing bambara groundnut through some processing methods such as roasting, germination, and extrusion. Future studies may include improving the sensory properties of products enriched with bambara groundnut as well as investigating the digestibility of the products using in vivo and in vitro methods.
Development of a M9‐based urea medium (M9U) for sensitive and real‐time monitoring of ureolytic activity of bacteria and cell‐free urease
Authors: Sigurdarson Jens Jakob , Svane Simon , Karring Henrik 
Published: January 2020

AbstractThe enzyme urease is widespread in nature and catalyzes the hydrolysis of urea to form ammonia and carbonic acid. The high proficiency of the enzyme is associated with a wide range of societal challenges. In agriculture, bacterial urease activity leads to loss of fertilizer through NH3 emission, which has a negative impact on the environment and human health. Urease is also an essential virulence factor for several pathogenic bacteria. To screen for potential urease inhibitors, efficient, sensitive, and accurate urease activity assays are needed. However, most urease activity assays are labor‐intensive and become time‐consuming when used to screen multiple samples. Based on systematic optimization, we have developed a urea‐containing growth medium and method for continuous real‐time monitoring and screening of urease activity from both bacterial cells and pure urease in a plate reader setup. The defined M9‐based urea (M9U) medium was found to be more sensitive and suitable for a plate reader setup than both Christensen's urea broth (CUB) and Stuart's urea broth (SUB), which are established and well‐known complex urea media that formed the principle foundation of M9U. Furthermore, we show that urease activity measurements using the M9U medium in our plate reader‐based method allow reliable high‐throughput screening of urease inhibitors.
Contrasting features of hydroclimatic teleconnections and the predictability of seasonal rainfall over east and west Japan
Authors: Maity Rajib , Chanda Kironmala , Dutta Riya , Ratnam J. V. , Nonaka Masami , Behera Swadhin 
Published: January 2020

AbstractHydroclimatic teleconnections between global sea surface temperature (SST) anomaly fields and monthly rainfall over east and west Japan (divided along 138° E longitude) are identified for summer (June–August) and winter (December–February) using the concept of global climate pattern (GCP). The analysis indicates that the hydroclimatic teleconnections over both regions vary at both intra‐ and inter‐seasonal time scales. In addition, the teleconnections over the two regions have differing origins. The teleconnection features associated with rainfall anomalies over west Japan have origins in the tropical Pacific and Indian oceans, whereas those over east Japan are associated with high‐latitude SST anomalies. The early summer (winter) rainfall over west Japan is linked to the El Niño Modoki (La Niña Modoki) phenomena, whereas the early summer and winter rainfall anomalies over east Japan are associated with the SST anomaly over the eastern subtropical Pacific and South Pacific oceans, respectively. Having identified the teleconnections, prediction model approaches—a machine‐learning approach, namely support vector regression (SVR), and a hybrid graphical modelling/C‐Vine copula (GM‐Copula)—were developed to forecast the rainfall over both east and west Japan. The predictors were derived from the monthly SST anomalies at different lags (1–6 months), and whereas the hidden, nonlinear relationship was well captured by the SVR approach, the complex association was decidedly better captured by the GM‐Copula approach. Hence, it is recommended for forecasting the rainfall over east and west Japan.
Efficient numerical algorithm for solving the gravimetry problem of finding a lateral density in a layer: Parallel implementation
Authors: Akimova Elena N. , Misilov Vladimir E. 
Published: January 2020

The paper is devoted to developing the new time‐ and memory‐efficient algorithm BiCGSTABmem for solving the inverse gravimetry problem of determination of a variable density in a layer using the gravitational data. The problem is in solving the linear Fredholm integral equation of the first kind. After discretization of the domain and approximation of the integral operator, this problem is reduced to solving a large system of linear algebraic equations.It is shown that the matrix of coefficients is the Toeplitz‐block‐Toeplitz one in the case of the horizontal layer. For calculating and storing the elements of this matrix, we construct an efficient method, which significantly reduces the required memory and time. For the case of the curvilinear layer, we construct a method for approximating the parts of the matrix by a Toeplitz‐block‐Toeplitz one. This allows us to exploit the same efficient method for storing and processing the coefficient matrix in the case of a curvilinear layer. To solve the system of linear equations, we constructed the parallel algorithm on the basis of the stabilized biconjugated gradient method with using the Toeplitz‐block‐Toeplitz structure of the matrix.We implemented the BiCGSTAB and BiCGSTABmem algorithms for the Uran cluster supercomputer using the hybrid MPI + OpenMP technology. A model problem with synthetic data was solved for a large grid. It was shown that the new BiCGSTABmem algorithm reduces the computation time in comparison with the BiCGSTAB. Scalability of the parallel algorithm was studied.
Comparison of health‐promoting behaviours, eating behaviour patterns and perceived social support in normal‐weight and overweight pregnant women: An unmatched case–control study
Authors: Hajian Sepideh , Fathnezhad‐Kazemi Azita 
Published: January 2020

AbstractAimThe interventions based on adopting a healthy lifestyle during pregnancy have conflicting results. This study aimed to compare health‐promoting, dietary patterns and social support in normal and overweight pregnant women.DesignAn unmatched case–control design was used.MethodsA total of 360 pregnant women were selected using multistage cluster sampling and divided into two groups of normal and overweight cases. Data were collected using demographic and obstetrics characteristics, health‐promoting lifestyle, perceived social support and eating behaviour questionnaires.ResultsThe evaluation of the health‐promoting behaviours and dietary patterns demonstrated a significant difference between the mean of total scores and their subdomains including self‐actualization, nutrition, consumption of healthy and low‐fat foods, fast food and sweets, as well as emotional eating and accidental planning. There was no significant difference between the two groups about social support.
Negative regulation of dendritic cell activation in psoriasis mediated via CD100–plexin‐B2
Authors: Xiao Chunying , Luo Yang , Zhang Chen , Zhu Zhenlai , Yang Luting , Qiao Hongjiang , Fu Meng , Wang Gang , Yao Xu , Li Wei 
Published: January 2020

AbstractPsoriasis is a chronic inflammatory skin disease in which dendritic cells (DCs) play a pivotal role by inducing Th1/Th17 immune responses; however, the regulation of DC activation in psoriasis remains largely unknown. Previously we found that the level of soluble CD100 was increased in sera of psoriasis patients, and CD100 promoted the activation of inflammasome in keratinocytes. In the present study, CD100 knockout mice were utilized for generation of imiquimod (IMQ)‐induced psoriatic dermatitis, with the result that skin inflammation in the early, but not late, phase of the psoriatic dermatitis was significantly exacerbated compared to that in wild‐type controls. This was attributed mainly to the deficiency of CD100 in hematopoietic cells. Bone marrow‐derived DCs, but not T cells or keratinocytes, from CD100 knockout mice produced significantly increased levels of IL‐1β, IL‐36, and IL‐23 upon stimulation with IMQ in a plexin‐B2‐dependent manner. Moreover, the surface level of plexin‐B2 on DCs of psoriasis patients was lower than that of healthy individuals, and CD100 attenuated IMQ‐induced production of IL‐1β and IL‐36 from monocyte‐derived DCs of psoriasis patients. Our results uncovered a negative regulatory mechanism for DCs activation in psoriasis, which was mediated via CD100–plexin‐B2 in a cell type‐ and receptor‐specific manner. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.