bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstructive trends and complications following parotidectomy: Incidence and predictors in 11,057 cases
Authors: Bovenzi Cory Donovan , Ciolek Peter , Crippen Meghan , Curry Joseph M. , Krein Howard , Heffelfinger Ryan 
Published: November 2019

Background Parotidectomy is a common treatment option for parotid neoplasms and the complications associated with this procedure can cause significant morbidity. Reconstruction following parotidectomy is utilized to address contour deformity and facial nerve paralysis. This study aims to demonstrate national trends in parotidectomy patients and identify factors associated with adverse postoperative outcomes. This study includes the largest patient database to date in determining epidemiologic trends, reconstructive trends, and prevalence of adverse events following parotidectomy. Methods A retrospective review was performed for parotidectomies included in the ACS-NSQIP database between January 2012 and December 2017. CPT codes were used to identify the primary and secondary procedures performed. Univariate and multivariate analysis was utilized to determine associations between pre- and perioperative variables with patient outcomes. Preoperative demographics, surgical indications, and common medical comorbidities were collected. CPT codes were used to identify patients who underwent parotidectomy with or without reconstruction. These pre- and perioperative characteristics were compared with 30-day surgical complications, medical complications, reoperation, and readmission using uni- and multivariate analyses to determine predictors of adverse events. Results There were 11,057 patients who underwent parotidectomy. Postoperative complications within 30 days were uncommon (1.7% medical, 3.8% surgical), with the majority of these being surgical site infection (2.7%). Free flap reconstruction, COPD, bleeding disorders, smoking, and presence of malignant tumor were the strongest independent predictors of surgical site infection. Readmission and reoperation were uncommon at an incidence of 2.1% each. The strongest factors predictive of readmission were malignant tumor and corticosteroid usage. The strongest factors predictive of reoperation were free flap reconstruction, malignant tumor, bleeding disorder, and disseminated cancer. Surgical volume/contour reconstruction was relatively uncommon (18%). Facial nerve sacrifice was uncommon (3.7%) and, of these cases, only 25.5% underwent facial nerve reinnervation and 24.0% underwent facial reanimation. Conclusions There are overall low rates of complications, readmissions, and reoperations following parotidectomy. However, certain factors are predictive of adverse postoperative events and this data may serve to guide management and counseling of patients undergoing parotidectomy. Concurrent reconstructive procedures are not commonly reported which may be due to underutilization or underreporting.
Thyroid and adrenal function in children born 5 years after the Chernobyl accident in economically unfavourable regions of Belarus
Authors: Boiko Yu. N. , Cherevko A. N. , Petrova A. M. , Zubovich V. K. 
Published: November 2019

Currently, there is no doubt the need to study the comprehensive influence of ionizing radiation one the body finctions. Under the influence of ionizing radiation, the development of compensatory and adaptive-adaptive mechanisms of the most radiosensitive organs and tissues to reduce post-radiation effects is of particular importance. Under these conditions, a change in the functional activity of the pituitary-thyroid and adrenal systems is possible, the hormones of which are actively involved in the main adaptation processes. A generally recognized fact is the high radiosensitivity of the above systems, especially in a growing childs body.
In the first days after the accident, the main biologically significant radionuclides were iodine isotopes, which caused the formation of dose loads on the thyroid gland. At present, the long-lived radionuclides 13^Cs and 90Sr have a decisive influence on the radiation situation in the republic. The greatest contribution to the radiation dose is made by cesium radionuclides.
Some authors studied the functional state of the pituitary-thyroid system in children exposed in 1986 to radioactive iodine in the ante- and postnatal periods.
Issues of the occurrence of functional changes in the thyroid gland and adrenal cortex, induced by the intake of radionuclides that are not deposited in these organs, have hardly been studied.
Of considerable interest is the study of the state of the functions of the thyroid gland and adrenal cortex in children born and living under the influence of low doses of radiation, whose mothers were exposed to radioactive iodine.
Multimodal feature learning and fusion on B-mode ultrasonography and sonoelastography using point-wise gated deep networks for prostate cancer diagnosis
Authors: Zhang Qi , Xiong Jingyu , Cai Yehua , Shi Jun , Xu Shugong , Zhang Bo 
Published: November 2019

Abstract
B-mode ultrasonography and sonoelastography are used in the clinical diagnosis of prostate cancer (PCa). A combination of the two ultrasound (US) modalities using computer aid may be helpful for improving the diagnostic performance. A technique for computer-aided diagnosis (CAD) of PCa is presented based on multimodal US. Firstly, quantitative features are extracted from both B-mode US images and sonoelastograms, including intensity statistics, regional percentile features, gray-level co-occurrence matrix (GLCM) texture features and binary texture features. Secondly, a deep network named PGBM-RBM2 is proposed to learn and fuse multimodal features, which is composed of the point-wise gated Boltzmann machine (PGBM) and two layers of the restricted Boltzmann machines (RBMs). Finally, the support vector machine (SVM) is used for prostatic disease classification. Experimental evaluation was conducted on 313 multimodal US images of the prostate from 103 patients with prostatic diseases (47 malignant and 56 benign). Under five-fold cross-validation, the classification sensitivity, specificity, accuracy, Youden’s index and area under the receiver operating characteristic (ROC) curve with the PGBM-RBM2 were 87.0%, 88.8%, 87.9%, 75.8% and 0.851, respectively. The results demonstrate that multimodal feature learning and fusion using the PGBM-RBM2 can assist in the diagnosis of PCa. This deep network is expected to be useful in the clinical diagnosis of PCa.
Does antenatal education decrease the cesarean rates in nulliparous women?
Authors: TÜRKLER Can 
Published: November 2019

Objective: In recent years, cesarean rates have increased
and healthcare systems have tried several ways to correct this situation.
Antenatal education programs are one of them. The aim of this study was to determine the effect of
antenatal education on cesarean rates in nulliparous women.Material and
Methods: This is a retrospective, cohort study. In total,
200 nulliparous women who were given birth at our hospital (educated group,
n = 86 and uneducated group, n = 114) participated in the study. Data were collected from the antenatal
education class forms and patient files.Results: The rate of cesarean section in the group receiving antenatal education was found 30.2% and the rate of cesarean section in the uneducated group was 36.8%. It was statistically significant (p&lt;0,05).

Conclusion: The rate of
cesarean section decreases in nulliparous women who were taken antenatal
education. In addition, antenatal education programs must be standardized and
the number of participants should be increased all over the world.
Prevalence of risk factors of cardiovascular complications in elderly women with left breast cancer
Authors: Vologdina I. V. , Poroshina E. G. , Zhabina R. M. , Stanzhevsky A. A. 
Published: November 2019

The purpose to study the risk factors for elderly women with left breast cancer at the stage of chemotherapy and radiotherapy in the context of daily clinical practice for early detection of possible cardiovascular complications and optimization of therapy.
Material and methods. 69 women with HER2 neu negative left breast cancer without severe cardiovascular disease were examined. The first group included 39 elderly patients (67.7 3.8 years). The second group consisted of 34 middle-aged patients (49.8 5.7 years). In addition to the risk assessment according to the Score scale, additional factors including psychosocial factors were studied. The examination was carried out before the start of treatment, after the end of the course of doxorubicin in a cumulative dose of up to 360 mg/m2 and after the completion of radiation therapy 3D conformal radiation therapy SOD 39 Gr.
Results. In elderly patients, risk factors such as obesity, increased cholesterol, and hypertension were significantly more common. In both study groups, low physical activity was revealed associated with both cancer itself and the treatment. All examined patients had moderate reactive anxiety on the Spielberger-Hanin scale. Elderly patients showed high level of personal anxiety; the number of points scored 49.3 3.6. According to the Score scale, a moderate risk was detected in 18 (58.1%) and a high risk in 13(41.9%) elderly patients. After doxorubicin treatment asymptomatic systolic dysfunction was detected in 8 (20.5%) patients (decrease in EF50%), 21 (75%) diastolic dysfunction with relaxation slowdown (E/A1). In 9 (23.1%) of the women without reducing the EF fibrotic changes in the myocardium of the left ventricle was revealed. In 8 (20.5%) women a thickening of the pericardial layer was revealed.
Conclusion. The findings suggest the need for a personalized approach and assessment of risk factors in patients of different age groups with left breast cancer at the stage of preparation and conduct of chemoradiotherapy. This highlights the need for enhanced history collection and consideration of not only key but also additional risk factors. The results of the study can be used in the work of practical health care institutions for the planning, development, implementation and control of chemoradiography safety in terms of preventing cardiovascular complications.
Directivity of M 3.1 Earthquake near Anza, California and the Effect on Peak Ground Motion
Authors: Fletcher Jon B. , Boatwright John 
Published: November 2019

ABSTRACTWe show the effect of rupture directivity on peak ground-motion values for a moderate magnitude event at Anza, California, and neighboring stations at the Imperial Valley. The event was located near Borrego Springs on the west side of the Salton Sea and was well recorded at broadband stations near Anza, California, and at stations on the west side of the Imperial Valley. After correcting for regional attenuation, an anomalously large residual in peak motion was observed at station ERR just to the southeast of the epicenter. Using the algorithm from Boatwright (2007), peak motions from the regional seismic networks in southern California were inverted to determine directivity, which was to the southeast along the trend of the San Jacinto fault toward station ERR. This algorithm uses peak values compiled for the ShakeMap system mostly at regional distances. It does not capture the main features of the source time function (STF) predicted by directivity. Consequently, we determined the second-degree moments for this earthquake, which confirmed that station ERR has a shorter and higher STF compared to stations to the northwest suggesting rupture propagated to the southeast. The azimuthal distribution of local stations is sparse, but nevertheless the largest amplitudes (such as at station ERR) correlate well with the maximum in the radiation pattern and smaller values with the minima, which is the radiation pattern for SH plus the effect of directivity. Using the data from the analysis of the second-degree moments, the characteristic length of the fault is 0.58 km, assuming an idealized unilateral extended rupture with a rupture time of 0.09 s. This yields an apparent rupture velocity of 6.4  km/s for an idealized model, which is super shear. This value is model dependent and would change if, for example, the rupture was bilateral. Although this value is even greater than the P-wave velocity, it supports the idea that the rupture velocity is super shear and would enhance the correlation between the peak motions and the radiation pattern.
Time deals: optimization of lag
Authors: Shabanov Timofey Yu. 
Published: November 2019

Relevance. In many ways, a successful purchase and sale transaction is determined by the time it takes to complete it. The search for the best deal time is linked to the optimization of the time lag. The purpose of the study is to optimize the time lag of the agricultural market.Methods. This article considered a role of time in business processes for Russian potato market of producer into period 1998-2018.Results. There was trend of annual reduction about 365 thousand tons (1.2...1.7% of total) per year supply of potatoes on Russian domestic market of producers. Some priority of quantity vs price of producer been revealed. There was inverse proportional function between producers` prices and quantity of potatoes. That is than worse harvest that higher producer`s price. Reducing a supply of potatoes 1 million tons from agricultural market perhaps increase in producer prices by $ 8.5 / t (4...5% on average). Offered concept and hypothesis about linearization of equilibrium of market processes into conditions of time shifts of dynamics their parameters were confirmed. There verified assumption about existence of inter-interval time optimum which this linearization maximal business processes. In course of correlation analysis of dynamics of annual indicators of potato market, it revealed month May of current period as optimal time of producer's offers with price restrictions and diminishing returns, and month September with quantity restrictions and increasing returns. If fixation of producer`s prices situation of deals May more likely, in case of crop failure (limited quantity) in September.
Gensini score predicts postoperative atrial fibrillation following on-pump coronary artery bypass grafting
Authors: KARAÇAĞLAR Emir , AKGÜN Arzu , ÇİFTCİ Orçun , MÜDERRİSOĞLU Haldun 
Published: November 2019

Aim: Postoperative
atrial fibrillation (POAF) is common after coronary artery by-pass grafting
surgery (CABG) and associated with adverse events. GENSINI score is a
widely-used scoring system that quantifies angiographic atherosclerosis. The
value of GENSINI score to predict POAF has not been studied previously. Aim of
this study was to evaluate this relationship in our patients undergoing on-pump CABG surgery.Material and Methods: In this
retrospective, single-center study, a total of 113 patients without exclusion criteria were included.
Demographic and clinical characteristics of patients were recorded and GENSINI scores
were calculated. Univariate
and multivariate logistic regression analyses were performed to identify the
independent predictors of POAF.Results: Postoperative atrial fibrillation developed in
34 (30%) patients. Multivariate logistic regression analyses
revealed that C-Reactive Protein [ß=0.037, p=0.011, OR=1.03, 95% CI
(1.008-1.065)] and GENSINI score [ß=0.015, p=0.024,OR=1.012, 95% CI
(1.002-1.028)] are independent
predictors of POAF. The ROC analysis showed an area under the curve of 0.587 (p=0.012). GENSINI score of &gt; 50.75 had 82.4%
sensitivity in predicting POAF [p=0.012, 95%CI (0.464-0.711)].

Conclusion: Our results showed
that GENSINI score is an independent predictor of POAF in patients undergoing on-pump CABG surgery.
Editöre mektup: Vücut kitle indeksi ile ortalama trombosit hacmi arasında herhangi bir ilişki bulunmayabilir
Authors: BEYAN Cengiz , BEYAN Esin 
Published: November 2019

Karakurt ve arkadaşlarının çocuk ve adölesanlarda vücut kitle indeksi ile ortalama
trombosit hacmi (MPV) arasındaki ilişkiyi inceleyen araştırmalarını büyük bir ilgi
ile okuduk Biz bu çalışma hakkında yorum
yapmak istiyoruz.
Ozon uygulaması ve oral cerrahideki yeri: Derleme
Authors: BOĞAÇ Pembe , ERKMEN Erkan 
Published: November 2019

Ozon
(O₃) üç oksijen atomundan oluşan renksiz
, keskin kokulu doğal bir gazdır. Atmosferin stratosfer tabakasında bulunur ve
güneşten gelen zararlı ultraviyole ışınlarını süzer. Keşfinden sonraki ilk
yıllarda dezenfeksiyon amacıyla kullanılırken yıllar içinde yapılan çalışmalar
tıp alanında kullanımını artırmıştır. Antimikrobiyal , biyosentetik, analjezik
, antihipoksik , immünmodülatör gibi özellikleri bulunan ozonun tedavi amacıyla
kullanılması ile ilgili günümüzde birçok
çalışma yapılmaktadır. Bu derlemede ozon ve ozonun kullanım alanları ile yara iyileşmesi
üzerindeki etkilerinden bahsedilmiştir.
Adölesan idiopatik skolyozlu hastalarda Boston tipi korse kullanımının yaşam kalitesine etkisi
Authors: YAPAR Aliekber , ŞENKÖYLÜ Alpaslan 
Published: November 2019

Amaç: AdölesanİdiopatikSkolyoz
(AİS) nedeniyle konservatif tedaviuygulanan hastalarda, korse (Boston tipi) kullanımının yaşam kalitesine etkisiniSkolyoz
Araştırma Cemiyeti’nin Sağlık ilişkili Yaşam Kalitesi-22 (Scoliosis Research
Society- 22; SRS-22) anketi ile değerlendirmekGereç ve Yöntemler: Araştırma
kesitsel tipte bir çalışmadır. Gazi Üniversitesi Tıp Fakültesi Hastanesi
Ortopedi ve Travmatoloji Kliniğinde 2008 - 2017 yılları arasında tanı almış ve
en az bir yıldır AİS tanısıyla takip edilen, konservatif tedavi uygulanan, yaş
ortalaması 16,0±2,9 (min:11,00; maks:26) olan 22’si erkek (%32,4), 46’sı kadın
68hasta çalışmaya dâhil edilmiştir. Hastaların yaşam kalitesini değerlendirmek
için SRS-22 anketi kullanılmıştır.Bulgular:
Çalışmaya katılan hastaların23’ü (%33,8)korse ile45’iise korsesiz takip
edilmiştir.Hastaların son kontroldeki Cobb açısı dereceleri korse ile takip
edilen grupta istatistiksel olarak anlamlı yüksek bulunmuştur (p&lt;0,001).
Korse ile takip edilen ve korsesiz takip edilen her iki grup arasında SRS-22
toplam skoru, ağrı, fonksiyon, ruh sağlığı ve tedaviden tatmin skorları
açısından istatistiksel olarak anlamlı fark bulunmamıştır (p&gt;0,05). SRS-22
görünüş skorunun ise korse ile takip edilen grupta istatistiksel olarak anlamlı
düzeyde daha düşük olduğu saptanmıştır (p=0,019).

Sonuç:
Bu çalışmada korseli hastaların yaşam kalitelerininkorsesiz takipedilenlerle
benzer olduğu saptanmıştır. Korseli grubun Cobb açı değerlerinin diğer gruba
göre daha yüksek olması nedeniyle SRS-22 görünüş skorunun korselilerde daha
düşük olduğu saptanmıştır. Korseli hastaların ağrı, fonksiyon, ruh sağlığı ve
tedaviden tatmin ile ilişkili yaşam kalitelerinin benzer olduğu ve genel olarak
yaşam kalitelerinin korseden etkilenmediği bulunmuştur.
Múltiples caras de la inmigración cubana. Tesis para un debate
Authors: Cobas Cobiella María Elena 
Published: November 2019

El trabajo tiene como objetivo introducir al lector en algunas cuestiones de interés en relación a la normativa migratoria cubana, resaltando algunos conceptos de relevancia para los lectores ávidos en la materia y sobre todo en el complejo mundo del derecho cubano sumergido en las indefiniciones. Trata además de la cuestión de la “llamada repatriación “como punto central del debate.
MicroRNA-200b reduced ZEB1 to inhibit cell proliferation and migration in human gastric cancer
Authors: Chen He , Liu Pengcheng , Wang Lei , Yu Yanxia , Zhao Yan , Cai Yihong , Wang Zhongxin , Zhang Min 
Published: November 2019

Abstract
BACKGROUND Gastric cancer (GC) is one of the most common malignant cancers, with high morbidity and mortality rates worldwide. The present study was to explore whether miR-200b is a tumor suppressor in GC and to unveil the potential mechanisms.METHODS Levels of c-Myc, Cyclin D1, MMP-3 and MMP-9 expression were detected respectively by q-PCR and Western blot assay. BrdU proliferation assay, Cell cycle analysis and Wound-healing were used to study the role of miR-200b with inhibitor, mimics or ZEB1-RNAi in TGF-β1-treated SGC-7901/DDP cells.RESULTS Compared with the paracancerous tissues, miR-200b was decreased in GC patients and SGC-7901/DDP cells. Lower level of miR-200b induced by its inhibitor promoted TGF-β1-treated SGC-7901/DDP cells proliferation and migration, and increased the levels of c-Myc, Cyclin D1, MMP-3, and MMP-9. Interestingly, miR-200b mimics and ZEB1-RNAi were able to reduce the proliferation and migration of TGF-β1-induced SGC-7901/DDP cells as well as their levels of c-Myc, Cyclin D1, MMP-3 and MMP-9. In addition, ZEB1 was indeed the potential target of miR-200b identified by dual luciferase reporter gene assay.CONCLUSION Taken together, our findings suggest that miR-200b be likely to play an important role in activating TGF-β1-induced SGC-7901/DDP cells and perform as a tumor suppressor by targeting ZEB1 in GC.
Possible health impacts due to animal and human fecal pollution in water intended for drinking water supply of Rio de Janeiro, Brazil
Authors: Bianco Kayo , Albano Rodolpho Mattos , de Oliveira Samara Sant'Anna , Alves Nascimento Ana Paula , dos Santos Thaís , Clementino Maysa Mandetta 
Published: November 2019

AbstractFecal matter is considered as one of the worst pollutants in waterbodies due to the potential spread of waterborne diseases. This study aimed to determine the host-specific fecal contamination in two Brazilian watersheds and to predict the possible impacts on human health. Fecal sources were enumerated using host-specific genetic markers to swine (16S rRNA), human and bovine (archaeal nifH), and equine (archaeal mcrA). A single cycling condition was established for four markers aiming to decrease the analysis time. Fifteen samples from São João watershed (75%) and 25 from Guandu (62.5%) presenting Escherichia coli enumeration in compliance with Brazilian guidelines (&lt;1,000 MPN/100 mL) showed the human marker. Furthermore, the bovine, swine, and equine markers were present in 92% (59/64), 89% (57/64), and 81% (52/64) of the water samples, respectively. The molecular markers proposed for qPCR in our study were sensitivity and specific enough to detect host-specific fecal pollution in all samples regardless of E. coli levels reaffirming the low correlation among them and supporting their use in water quality monitoring programs. To our knowledge, this is the first study using this approach for quantification of nifH, mcrA, and rrs gene-associated human and animal fecal pollution in waters intended for drinking water supply in Brazil.
Synthesis and Evaluation of N-substituted (Z)-5-(Benzo[d][1,3]dioxol-5- ylmethylene)-2-Thioxothiazolidin-4-one Derivatives and 5-Substituted- Thioxothiazolidindione Derivatives as Potent Anticonvulsant Agents
Authors: Dong Shiyang , Liu Yanhua , Xu Jun , Hu Yue , Huang Limin , Wang Zengtao 
Published: November 2019

Background:
Epilepsy is a serious and common neurological disorder threatening the
health of humans. Despite enormous progress in epileptic research, the anti-epileptic drugs present
many limitations. These limitations prompted the development of more safer and effective AEDs.

Methods:
series of N-substituted (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)- 2-thioxothiazolidin-4-
one derivatives and 5-substituted-thioxothiazolidindione derivatives were designed, synthesized and
tested for anticonvulsant activity against maximal electroshock (MES) and subcutaneous pentylenetetrazole
(scPTZ). Neurotoxicity was determined by the rotarod test.

Results:
Among them, the most potent 4e displayed high protection against MES-induced seizures
with an ED50 value of 9.7 mg/kg and TD50 value of 263.3 mg/kg, which provided 4e with a high protective
index (TD50/ED50) of 27.1 comparable to reference antiepileptic drugs. 4e clearly inhibits the
NaV1.1 channel in vitro. The molecular docking study was conducted to exploit the results.

Conclusion:
Stiripentol is a good lead compound for further structural modification. Compound 4e
was synthesized, which displayed remarkable anticonvulsant activities, and the NaV1.1 channel inhibition
was involved in the mechanism of action of 4e.