bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drying microclimates threaten persistence of natural and translocated populations of threatened frogs
Authors: Hoffmann Emily P. , Williams Kim , Hipsey Matthew R. , Mitchell Nicola J. 
Published: October 2020

AbstractDefining species habitat requirements is essential for effective conservation management through revealing agents of population decline and identifying critical habitat for conservation actions, such as translocations. Here we studied the habitat-associations of two threatened terrestrial-breeding frog species from southwestern Australia, Geocrinia alba and Geocrinia vitellina, to investigate if fine-scale habitat variables explain why populations occur in discrete patches, why G. alba is declining, and why translocation attempts have had mixed outcomes. We compared habitat variables at sites where the species are present, to variables at immediately adjacent sites where frogs are absent, and at sites where G. alba is locally extinct. Dry season soil moisture was the most important predictor of frog abundance for both species, and explained why G. alba had become extinct from some areas. Sites where G. alba were present were also positively associated with moss cover, and negatively with bare ground and soil conductivity. Modelling frog abundance based exclusively on dry season soil moisture predicted recent translocation successes with high accuracy. Hence, considering dry season soil moisture when selecting future translocation sites should increase the probability of population establishment. We propose that a regional drying trend is the most likely cause for G. alba declines and that both species are at risk of further habitat and range contraction due to further projected regional declines in rainfall and groundwater levels. More broadly, our study highlights that conservation areas in drying climates may not provide adequate protection and may require interventions to preserve critical habitat.
A Progressive Loss of phosphoSer138-Profilin Aligns with Symptomatic Course in the R6/2 Mouse Model of Huntington’s Disease: Possible Sex-Dependent Signaling
Authors: Baharani Akanksha , Wei Zelan , Roesler William J. , Mousseau Darrell D. 
Published: October 2020

AbstractThe R6/2 transgenic mouse model of Huntington’s disease (HD) carries several copies of exon1 of the huntingtin gene that contains a highly pathogenic 120 CAG-repeat expansion. We used kinome analysis to screen for kinase activity patterns in neural tissues from wildtype (WT) and R6/2 mice at a pre-symptomatic (e.g., embryonic) and symptomatic (e.g., between 3 and 10 weeks postnatal) time points. We identified changes in several signaling cascades, for example, the Akt/FoxO3/CDK2, mTOR/ULK1, and RAF/MEK/CREB pathways. We also identified the Rho-Rac GTPase cascade that contributes to cytoskeleton organization through modulation of the actin-binding proteins, cofilin and profilin. Immunoblotting revealed higher levels of phosphoSer138-profilin in embryonic R6/2 mouse samples (cf. WT mice) that diminish progressively and significantly over the postnatal, symptomatic course of the disease. We detected sex- and genotype-dependent patterns in the phosphorylation of actin-regulators such a ROCK2, PAK, LIMK1, cofilin, and SSH1L, yet none of these aligned consistently with the changing levels of phosphoSer138-profilin. This could be reflecting an imbalance in the sequential influences these regulators are known to exert on actin signaling. The translational potential of these observations was inferred from preliminary observations of changes in LIMK-cofilin signaling and loss of neurite integrity in neural stem cells derived from an HD patient (versus a healthy control). Our observations suggest that a pre-symptomatic, neurodevelopmental onset of change in the phosphorylation of Ser138-profilin, potentially downstream of distinct signaling changes in male and female mice, could be contributing to cytoskeletal phenotypes in the R6/2 mouse model of HD pathology.
Volatile Organic Compounds as Insect Repellents and Plant Elicitors: an Integrated Pest Management (IPM) Strategy for Glasshouse Whitefly (Trialeurodes vaporariorum)
Authors: Conboy Niall J.A. , McDaniel Thomas , George David , Ormerod Adam , Edwards Martin , Donohoe Paul , Gatehouse Angharad M. R , Tosh Colin R. 
Published: October 2020

AbstractThe glasshouse whitefly (Trialeurodes vaporariorum Westwood) is a polyphagous arthropod pest that is of particular detriment to glasshouse grown tomato (Solanum lycopersicum) across temperate regions of the world. Control of whiteflies with synthetic pesticides has resulted in the evolution of resistant genotypes and a reduction in natural enemies, thus highlighting the need for environmentally sound control strategies. Volatile organic compounds (VOCs) offer an environmentally benign alternative to synthetic chemical sprays and this study explored the use of VOCs as insect repellents and plant defence elicitors to control whiteflies on tomato in a commercial glasshouse setting. Limonene in the form of a volatile dispenser system was found to successfully repel whitefly from the target crop and increased fruit yield by 32% during a heavy whitefly infestation. Analysis of tomato herbivore induced plant volatiles (HIPVs) led us to select methyl salicylate (MeSA) as the plant elicitor and application of MeSA to un-infested tomato plants was found to successfully reduce whitefly population development and increase yield by 11%, although this difference was marginally statistically significant. Combination of these two methods was also effective but whitefly abundance in combined plots was similar to the standalone limonene treatment across the course of the experiment. All of the VOC based control methods we used had a negative impact on whitefly performance, with more pronounced effects during the first few weeks of infestation. In subsequent laboratory experiments, we found elevated peroxidase (POD) activity and a significant increase in TPX1 and PR1 transcripts in MeSA treated plants. This led us to deduce that MeSA immediately induced plant defences, rather than priming them. We did however see evidence for residual priming, as plants treated with MeSA and infested with whiteflies produced significantly higher levels of POD activity than whitefly infestation alone. Despite the fact that our treatments failed to synergise, our methods can be optimised further, and the effectiveness of the standalone treatments is promising for future studies. In particular, our repellent limonene dispensers were extremely effective at deterring whiteflies and offer a low economic cost and easy to implement whitefly control option. The methods we have used here could be incorporated into current integrated pest management (IPM) systems, a sustainable approach to pest control which will be central to our efforts to manage whitefly populations under glass in the future.
Power from indirect pain: a historical phenomenology of medical pain management
Authors: Sik Domonkos 
Published: October 2020

AbstractThe article aims at reconstructing how pain is used in contemporary societies in the process of engraving power. Firstly, a social phenomenological analysis of pain is conducted: Husserl’s and Merleau-Ponty’s ideas are used for clarifying the experience of pain itself; Elaine Scarry’s analyses are overviewed in order to reconstruct how pain contributes to the establishing of power. Secondly, this complex approach is applied in early modern context: the parallel processes of the decline of a transcendental and the emergence of a medical interpretation of pain is introduced, along with the marginalization of violence. Thirdly, the era characterized by the triumph of medical pain management is analysed: it is argued that the constitutive role of pain in establishing power does not cease to exist with the emergence of technologies of discursive governance (Foucault); it is an open question, what sort of power is engraved through pain understood in strictly medical frames.
Social dignity for marginalized people in public healthcare: an interpretive review and building blocks for a non-ideal theory
Authors: Schmidt Jante , Trappenburg Margo , Tonkens Evelien 
Published: October 2020

AbstractJacobson (Social Science & Medicine 64:292–302, 2007) finds two distinct meanings of “dignity” in the literature on dignity and health: (1) intrinsic human dignity and (2) social dignity constituted through interactions with caregivers. Especially the latter has been central in empirical health research and warrants further exploration. This article focuses on the social dignity of people marginalized by mental illness, substance abuse and comparable conditions in extramural settings. 35 studies published between 2007 and 2017 have addressed this issue, most of them identifying norms for social dignity: civilized interactions, non-stigmatizing treatment, treatment as unique individuals, being taken seriously, maintaining a positive identity, experiencing independence, relating to others, and participating in daily life. We argue that these norms belong to ideal theory, whereas we agree with Robeyns (Social Theory and Practice 34:341–362, 2008) and others that improving practice is better served by non-ideal theory. Towards this end, we derive from the literature four building blocks for a non-ideal theory of dignity: (1) avoid violations of dignity rather than seeking to promote it; (2) dignity is not a goal to be reached; it requires ongoing effort; (3) promoting dignity is a balancing act; contradictory norms can make it impossible to realize; and (4) dignity can be undermined by organizational and discursive constraints.
Features and applications of a field imaging chlorophyll fluorometer to measure stress in agricultural plants
Authors: Linn Alexander I. , Zeller Alexander K. , Pfündel Erhard E. , Gerhards Roland 
Published: October 2020

AbstractMost non-destructive methods for plant stress detection do not measure the primary stress response but reactions of processes downstream of primary events. For instance, the chlorophyll fluorescence ratio Fv/Fm, which indicates the maximum quantum yield of photosystem II, can be employed to monitor stress originating elsewhere in the plant cell. This article describes the properties of a sensor to quantify herbicide and pathogen stress in agricultural plants for field applications by the Fv/Fm parameter. This dedicated sensor is highly mobile and measures images of pulse amplitude modulated (PAM) chlorophyll fluorescence. Special physical properties of the sensor are reported, and the range of its field applications is defined. In addition, detection of herbicide resistant weeds by employing an Fv/Fm-based classifier is described. The PAM-imaging sensor introduced here can provide in-field estimation of herbicide sensitivity in crops and weeds after herbicide treatment before any damage becomes visible. Limitations of the system and the use of a classifier to differentiate between stressed and non-stressed plants based on sensor data are presented. It is concluded that stress detection by the Fv/Fm parameter is suitable as an expert tool for decision making in crop management.
New powers for Dispositionalism
Authors: Giannini Giacomo 
Published: October 2020

AbstractEstablishing Dispositionalism as a viable theory of modality requires the successful fulfilment of two tasks: (i) showing that all modal truths can be derived from truths about actual powers, and (ii) offering a suitable metaphysics of powers. These two tasks are intertwined: difficulties in one can affect the chances of success in the other. In this paper, I generalise an objection to Dispositionalism by Jessica Leech and argue that the theory in its present form is ill-suited to account for de re truths about merely possible entities. I argue that such difficulty is rooted in a problem in the metaphysics of powers. In particular, I contend that the well-known tension between two key principle of powers ontology, namely Directedness (all powers are “for” their manifestation) and Independence (some powers might fail to bring about their manifestation) has received an unsatisfactory solution so far, and that it is this unsatisfactory solution concerning the status of “unmanifested manifestations” that makes it hard for Dispositionalism to account for mere possibilia. I develop a novel account of the status of unmanifested manifestations and an overall metaphysics of powers which allows to better respond to Leech's objection and handle mere possibilia. The central idea of the proposal is that unmanifested manifestations are akin to mere logical existents, and are best characterised as non-essentially non-located entities.
Contact Angles in Two-Phase Flow Images
Authors: Khanamiri Hamid Hosseinzade , Slotte Per Arne , Berg Carl Fredrik 
Published: October 2020

AbstractIn this work, we calculate contact angles in X-ray tomography images of two-phase flow in order to investigate the wettability. Triangulated surfaces, generated using the images, are smoothed to calculate the contact angles. As expected, the angles have a spread rather than being a constant value. We attempt to shed light on sources of the spread by addressing the overlooked mesh corrections prior to smoothing, poorly resolved image features, cluster-based analysis, and local variations of contact angles. We verify the smoothing algorithm by analytical examples with known contact angle and curvature. According to the analytical cases, point-wise and average contact angles, average mean curvature and surface area converge to the analytical values with increased voxel grid resolution. Analytical examples show that these parameters can reliably be calculated for fluid–fluid surfaces composed of roughly 3000 vertices or more equivalent to 1000 pixel2. In an experimental image, by looking into individual interfaces and clusters, we show that contact angles are underestimated for wetting fluid clusters where the fluid–fluid surface is resolved with less than roughly 500 vertices. However, for the fluid–fluid surfaces with at least a few thousand vertices, the mean and standard deviation of angles converge to similar values. Further investigation of local variations of angles along three-phase lines for large clusters revealed that a source of angle variations is anomalies in the solid surface. However, in the places least influenced by such noise, we observed that angles tend to be larger when the line is convex and smaller when the line is concave. We believe this pattern may indicate the significance of line energy in the free energy of the two-phase flow systems.
The Use of 360° Video by International Humanitarian Aid Organizations to Spread Social Messages and Increase Engagement
Authors: García-Orosa Berta , Pérez-Seijo Sara 
Published: October 2020

AbstractThe article analyses 360° video production in international humanitarian aid nonprofit organizations from 2015 to 2019 as 360° video storytelling is one of the latest innovations in organizational digital communication. Through a content analysis and interviews, a specific use of the 360° video format for particular issues or campaigns in order to bring a distant reality to the organization’s audience has been detected. Thus, putting the users in the shoes of “the other” seems to be the objective pursued. NGOs may soon begin to understand long-term interactivity and engagement not just as action and reaction between organization and receiver (almost non-existent to date), but above all as the receiver’s behaviour, which they may strive to orient towards one of the organization’s end goals, depending on the communication strategy set by the organization’s director. With this objective, common to entities from other sectors, they could be moving towards an innovative conceptualization of engagement.
Addressing Unintentional Exclusion of Vulnerable and Mobile Households in Traditional Surveys in Kathmandu, Dhaka, and Hanoi: a Mixed-Methods Feasibility Study
Authors: Thomson Dana R. , Bhattarai Radheshyam , Khanal Sudeepa , Manandhar Shraddha , Dhungel Rajeev , Gajurel Subash , Hicks Joseph Paul , Duc Duong Minh , Ferdoush Junnatul , Ferdous Tarana , Urmy Nushrat Jahan , Shawon Riffat Ara , Long Khuong Quynh , Poudel Ak Narayan , Cartwright Chris , Wallace Hilary , Ensor Tim , Baral Sushil , Mashreky Saidur , Huque Rumana , Van Minh Hoang , Elsey Helen 
Published: October 2020

AbstractThe methods used in low- and middle-income countries’ (LMICs) household surveys have not changed in four decades; however, LMIC societies have changed substantially and now face unprecedented rates of urbanization and urbanization of poverty. This mismatch may result in unintentional exclusion of vulnerable and mobile urban populations. We compare three survey method innovations with standard survey methods in Kathmandu, Dhaka, and Hanoi and summarize feasibility of our innovative methods in terms of time, cost, skill requirements, and experiences. We used descriptive statistics and regression techniques to compare respondent characteristics in samples drawn with innovative versus standard survey designs and household definitions, adjusting for sample probability weights and clustering. Feasibility of innovative methods was evaluated using a thematic framework analysis of focus group discussions with survey field staff, and via survey planner budgets. We found that a common household definition excluded single adults (46.9%) and migrant-headed households (6.7%), as well as non-married (8.5%), unemployed (10.5%), disabled (9.3%), and studying adults (14.3%). Further, standard two-stage sampling resulted in fewer single adult and non-family households than an innovative area-microcensus design; however, two-stage sampling resulted in more tent and shack dwellers. Our survey innovations provided good value for money, and field staff experiences were neutral or positive. Staff recommended streamlining field tools and pairing technical and survey content experts during fieldwork. This evidence of exclusion of vulnerable and mobile urban populations in LMIC household surveys is deeply concerning and underscores the need to modernize survey methods and practices.
Konzepte und Implikationen der verminderten Schuldfähigkeit
Authors: Kröber Hans-Ludwig 
Published: October 2020

ZusammenfassungDie psychiatrische Feststellung einer überdauernd erheblich verminderten Schuldfähigkeit im Sinne von §21 StGB erfordert eine begründete Zuordnung zum Rechtsbegriff der „schweren seelischen Abartigkeit“ und auch einer dadurch beeinflussten motivationalen Steuerungsfähigkeit. Die psychiatrischen Konzepte, die sich im Verlauf der letzten 200 Jahre zur Frage der strafrechtlichen Verantwortlichkeit entwickelt haben, sind aber nicht reine Psychopathologie, sondern haben rechtspolitische Implikationen. So war die Einführung der „erheblich verminderten“ Schuldfähigkeit damit verknüpft, eine Handhabe für eine unbefristete Freiheitsentziehung sozial Devianter, möglicherweise psychisch Gestörter zu bekommen, die gefährlich, manchmal nur lästig sind. Es stellt sich anhand der Argumente für und gegen das Konstrukt einer verminderten Schuldfähigkeit die Frage, ob es einen Bereich jenseits von psychischer Gesundheit und psychischer Krankheit gibt, der geeignet ist, die Fähigkeiten einer Person zu verantwortlichem Handeln erheblich zu beinträchtigen. Dargestellt werden die forensisch-psychiatrischen Lösungsversuche dieses Problems, v. a. seit der Großen Strafrechtsreform 1975. Um zu verhindern, dass sozial abweichendes Verhalten mit dem Ziel einer prophylaktischen unbefristeten Freiheitsentziehung psychiatrisiert wird, sollte das Konzept der verminderten Schuldfähigkeit eng sein und wirklich psychiatrisch relevante Sachverhalte erfassen.
Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED
Authors: Sebastianelli A. , Spatafora P. , Morselli S. , Vignozzi L. , Serni S. , McVary K. T. , Kaplan S. , Gravas S. , Chapple C. , Gacci Mauro 
Published: October 2020

Abstract
Purpose of Review
Aim of our systematic review is to evaluate and summarize the efficacy and safety of tadalafil alone or in combination with tamsulosin for the management of lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and erectile dysfunction (ED).

Recent Findings
Daily tadalafil, in particular 5 mg, according to retrieved studies, appears to be both safe and effective in treating LUTS/BPH and ED, compared with placebo or tamsulosin. The combination of daily tadalafil 5 mg and tamsulosin 0.4 mg allows a better improvement of LUTS compared with both the monotherapies, even if with an increased, but acceptable and tolerated, adverse events rate. After discontinuation of tamsulosin or tadalafil in patients previously treated with their combination, the improvement of LUTS retains significance compared with baseline.

Summary
Tadalafil 5 mg should be considered a primary treatment option for patients with LUTS/BPH and ED. Evidence highlight an excellent tolerability, safety, and effectiveness profile, both alone or in combination with tamsulosin 0.4 mg. A better efficacy on LUTS relief has been observed for combination therapy, preserving also sexual function. The further switch to monotherapy allows to preserve LUTS relief, but tadalafil only is able to retain ED improvement. Our results support the evidence for a more and more tailored and modular LUTS treatment.
An experimental-numeric approach to manufacture semiconductor wafer using thick copper front metallization
Authors: Calabretta Michele , Sitta Alessandro , Oliveri Salvatore Massimo , Sequenzia Gaetano 
Published: October 2020

AbstractThe presented work investigates about the deformation of semiconductor device induced by electrochemical deposited thick copper films. It enhances thermal and electric performances allowing to use copper interconnections without formations of intermetallic layers at the interfaces with consequent reliability improvement. Nevertheless, the induced deformation strongly affects manufacturability, criticizing the integration between different process steps. Experiment based on phase-shift Moiré principle has been performed to better understand the relation between warpage and temperature. Finite element model has been developed to reproduce the phenomenon in order to address the design and the process integration optimizing workability, electrical performances and reliability.
Complications of chronic total occlusion percutaneous coronary intervention
Authors: Karacsonyi J. , Vemmou E. , Nikolakopoulos I. D. , Ungi I. , Rangan B. V. , Brilakis E. S. 
Published: October 2020

AbstractChronic total occlusion percutaneous coronary interventions can be highly complex and are associated with an increased risk of complications, such as perforation, acute vessel closure (which can lead to rapid haemodynamic compromise if it involves the donor vessel), and equipment loss or entrapment. Awareness of the potential complications and meticulous attention to equipment position and patient monitoring can help minimise the risk of complications and allow prompt treatment should they occur.