bluuebunny/crossref_metadata_2025_split huggingface dataset:
PECULIARITIES OF RISK FACTORS FOR GLAUCOMA PROGRESSION AND THEIR IMPACT ON DEVELOPMENT OF THE DISEASE
Authors: Koshchynets O. B. , Kapechuk V. V. , Krytsun N. U. 
Published: December 2019

Objective: To identify factors of glaucoma progression andt heir impact on the development of late-stage glaucoma.
Materials and methods. Analysis of literary sources, sociological and medical-statistic. As part of a special program running at three in-patient ophthalmology departments at district hospitals in Ivano-Frankivsk region. A representative group of 515 people with primary glaucoma, including 347 respondents from I-II (initial) stage of primary glaucoma and 168 patients of III-IV (later) stages of the disease have been surveyed.
Results and discussion. It was proved that the chances of complicated course of glaucoma increase with age, in males, in patients with burdened heredity and concomitant cardiovascular diseases. Poor education, unemployment, loneliness, poor physical and social activity, harmful habits facilitate vision deterioration in glaucoma patients.
Conclusions. It was reported that the development of late-stage glaucoma significantly decreases quality of life by deteriorating health, decreased daily activity, increased anxiety and depression, elevated sense of social insecurity. The chances of late-stage glaucoma development increase with insufficient coverage by ophthalmological screening and low compliance tot reatment. This indicates the potential to prevent complications of glaucoma at the level of primary healthcare.
INFLUENCE OF BLOOD PRESSURE VARIABILITY ON COGNITIVE FUNCTION IN PATIENTS WITH DYSCIRCULATORY ENCEPHALOPATHY (LITERATURE REVIEW)
Authors: Ovodyuk N. M. 
Published: December 2019

Goal. To review the literature on the problem of the influence of variability of blood pressure on the cognitive function of patients with dyscirculatory encephalopathy after suffering ischemic stroke on the background of hypertension.
Research Methods: Bibliosemantic, Comparative and Systemic Results. In the Recommendations of the European Society of Cardiologists / European Society for Hypertension (European Approach).
Society for Cardiology / European Society of Hypertension - ESC / ESH) 2018 for the treatment of hypertension emphasized that the study of cognitive function (CF) should be mandatory in the list of methods of examination of patients to detect the damage of target organs caused by hypertension, in order refinement of stratification of risk of cardiovascular events, namely stroke (Williams B. et al., 2018). Cognitive impairment in patients with cardiovascular disease is known to be one of the earliest and most sensitive indicators of cerebral vascular injury and is a consequence of chronic cerebral ischemia and / or recurrent acute cerebral circulation disorders. It is proved that the variability of blood pressure has a negative effect on cerebral circulation, is a predictor of chronic brain ischemia, which can result in the appearance or deepening of cognitive impairment. In the ASCOT study on the prognostic significance of variability in daily monitoring of blood pressure, intracutaneous variability, and long-term variability, it was found that visit-to-visit variability is a strong predictor of stroke and coronary events, not independent of the level.
Conclusions. Analysis of the literature on this problem has shown the negative effect of blood pressure variability on the course of chronic brain ischemia, which exacerbates cognitive and emotional-volitional disorders in patients with hypertensive dyscirculatory encephalopathy. The peculiarities of the effect of blood pressure variability on CF in patients with brain stroke are poorly understood and need further investigation.
THE ROLE OF THE FAMILY DOCTOR IN THE MANAGEMENT OF PATIENTS WITH PSORIASIS
Authors: Bevzenko T. B. , Mantula A. A. 
Published: December 2019

Psoriasis is a common multifactorial, immunoassociated disease. Approximately one-third of patients have the disease in a recurrent manner and have a moderate or severe course. In addition to dermatological manifestations and lesions of the musculoskeletal system systemic manifestations and certain comorbid conditions are often observed in psoriasis: diabetes mellitus, hypertension, obesity and others. A patient with psoriasis falls into the professional field of interest of doctors in the following specialties: family doctor, dermatologist, rheumatologist, traumatologist, endocrinologist, cardiologist.
At the present phase of reforming of the health care system, in our opinion, the regulation of medical-diagnostic measures for GPs is especially relevant. The article presents in detail the route and management of a patient with psoriasis, psoriatic arthritis. Patients should be consulted annually by their GP, which includes documenting the severity of the disease using the DLQI scale, screening for depression, assessing cardiovascular risk, assessing joint symptoms, optimizing local therapy, evaluating the need for referral to a secondary care facility. Active intervention is needed to improve patients' quality of life and reduce the probability of psychosocial consequences.
The problem of psoriasis is an relevant medical, social and economic challenge in Ukraine. Undoubtedly, сonsidering the systemic nature of psoriatic disease and comorbidities, a personalized and multidisciplinary approach is required. Forehanded diagnostic, treatment measures, as well as collaborations with related professionals by family doctors determine the prognosis for the health and quality of life of a patients with psoriasis.
THE IMMUNOMODELING ACTIVITY OF BISMUTH CITRATE IN EXPERIMENT 1-CSTL AND LABORATORY OF INDUSTRIAL TOXICOLOGY
Authors: Hrushka О. I. , Turkina V. A. , Kuzminov B. P. 
Published: December 2019

The aim of the study. To investigate in experimental conditions the effect of bismuth citrate on the immune system of laboratory animals.
Material and methods. One-time sensitization of tadpoles (subcutaneously into the ear) was performed according to the method of O.G. Alekseeva, A.I. Petkevich. The degree of sensitization was established after skin tests. Determined the leucocyte blood formula, T and B lymphocytes in peripheral blood by the rosette method, immunoglobulins of class A, M, G in serum - by the method of radial immunodiffusion of globulines in agar Difco, circulating and extracellular complexes detection of the response of blood cells to the allergen "in vitro" - by the reaction of specific leukocyte lysis.
Results. Bismuth citrate causes impaired immunological homeostasis in experimental animals. Indicators of nonspecific cellular component of the immune system have changed significantly, characterizing immunocomplex pathology. A decrease in the T-helper subpopulation was observed, indicating a significant immunomodulatory ability of bismuth citrate. At the same time, there was a significant increase in cells capable of rosette formation, which suggests that bismuth citrate is capable of provoking sensitization of the body. In the humoral immunity link, significant differences in the content of circulating immune complexes in sensitized and control animals were observed. Immunoglobulin levels were unchanged relative to control. The analysis of the sensitizing effect indicates that the most probable result of sensitization of the organism in this mode of receipt of bismuth citrate is the formation of type III hypersensitivity.
Conclusions. Bismuth citrate under experimental conditions causes changes in the immune system of experimental animals, which are characteristic of the allergenic response of the organism to the complement-dependent type.
Manajemen Privasi Jemaat Ahmadiyah di Kota Semarang
Authors: Syaoki Muhammad 
Published: December 2019

Abstrak: Penelitian ini bertujuan untuk menggambarkan perilaku komunikasi Jemaat Ahmadiyah dalam posisi mereka sebagai kelompok yang dilarang menyebarkan ajarannya. Dengan menggunakan teori manajemen privasi komunikasi yang diperkenalkan oleh Sandra Petronio, penelitian ini berusaha menjelaskan proses dialektis yang dilakukan oleh jemaat Ahmadiyah di kota Semarang ketika berinteraksi dengan banyak orang dalam kehidupan sehari-hari. Hasil penelitian ini menunjukkan bahwa Jemaat Ahmadiyah melakukan pembukaan informasi privat dengan komunikasi langsung dan tidak langsung. Jemaat Ahmadiyah melakukan pembukaan informasi privat bertujuan untuk mengklarifikasi kesalahpahaman ghair tentang Ahmadiyah. Jemaat Ahmadiyah kota Semarang cenderung menutup informasi privat mereka kepada keluarga dan teman ketika mereka baru berbai’at. Mereka juga menutup informasi privat kepada orang-orang Muhammadiyah, serta kepada kelompok-kelompok Islam garis keras, seperti FPI, LDII, termasuk juga kader PKS. Tetapi mereka membuka informasi mengenai Ahmadiyah kepada orang-orang dari kalangan NU, dan aparatur pemerintah. Abstract : This research aims to describe the behavior of Ahmadiyyah community in their position as a group that is prohibited from spreading its teachings. Using the communication privacy management theory introduced by Sandra Petronio, this research attempts to explain the dialectical process undertaken by the Ahmadiyah community in the Semarang city while interacting with many people in everyday life. The results of this study indicate that the Ahmadiyyah community conducts the opening of private information with direct and indirect communication. The Ahmadiyah community conducted the opening of private information aimed to clarify misunderstanding about “ghair” of Ahmadiyah. The Ahmadiyah community of Semarang tends to hide their private information from family and friends when they are newly banned. They also hide private informations to Muhammadiyah people, as well as to hard-line Islamic groups, such as FPI, LDII, as well as PKS cadres. But they do not hide information about Ahmadiyyah to people from the NU, and the government apparatus.
Gejala Media Sosial Twitter Sebagai Media Sosial Alternatif
Authors: Zukhrufillah Irfani 
Published: December 2019

Abstrak: Kajian ini tertujuan untuk mengetahui sejarah perkembangan teknologi komunikasi hingga memasuki era digital dan social media. Terlebih media social twitter yang perkembangannya pesat dan pengguna di Indonesia pun mengalami kenaikan yang semakin signifikan. Kajian ini menggunakan landasan teori peluru dan agenda setting. Hasilnya dapat dilihat bahwa dari gejala-gejala yang muncul, dapat dikatakan bahwa twitter menjadi media alternative setelah para pendahulunya seperti radio, televisi dan koran. Penyebutan sebagai media alternatif ini bukan tanpa bukti. Para penggunanya yang semakin besar juga diwujudkan dalam keaktifan mereka dalam mentweet kegiatan sehari-hari. Bahkan tidak jarang para follower mengetahui berita tentang seseorang dari twitter. Para pengguna juga semakin berlomba mendapatkan follower demi verifikasi yang dilakukan oleh twitter sendiri. Abstract : This study aims to know the history of the development of communication technology in arrival of digital and social media era. Moreover social media twitter that has develop faster and users in Indonesia also increase significantly. This study uses a bullet theory and agenda setting. The results can be seen that from the symptoms that appear, it can be said that twitter became an alternative media after its predecessors such as radio, television and newspapers. The mention of this alternative medium is not without evidence. The larger users are also embodied in their activities in tweeting their daily activities. In fact, not infrequently the follower knows news about someone from twitter. The users are also increasingly competing to get follow-up follower by the twitter itself.
SELF-ACUPRESSURE TO LOWER BLOOD PRESSURE ON OLDER ADULTS WITH HYPERTENSION
Authors: Dermawan Agus Citra , Setiawati Santun , Maryam Raden Siti 
Published: December 2019

Hypertension is often suffered by older adults, which directly can impact their health and quality of life. One of the non-pharmacological management for patients with hypertension is through acupressure to accelerate blood-flow circulation and to reduce blood pressure.Â This study aims to determine the self-acupressure effect on the elderly with hypertension in Cilincing Health Center in North Jakarta. This research used a quasi-experimental involving control and intervention group. Thirty-six elderlies were involved in this study divided into two groups. Findings showed that there were significant differences in the intervention group between the results of systolic and diastolic measurements before and after acupressure (p-value=0,000). The findings suggest that families can apply self-acupressure as a support system for older adults with hypertension.
LEVELS OF MINERALS, VITAMIN AND POWER RECEIVED IN DRINK INFUSED WATER WITH DIVERSIFICATION
Authors: Surati Surati , Widiyanto SY. Didik , Qomariyah Nurul , Wikandari Ririh Jatmi 
Published: December 2019

Infused water is drinking waterÂ that has been given additional pieces of fruit so that the water gives a certain sensation of water. Infused water are consumed by the community because the manufacturing process is easy and use local fruits. To determine the vitamin content (A and C), mineral content (K, Ca, Mg) and acceptability of infused water with sample codes (A, B and C). The benefits of this study are to be able to add to the list of healthy and nutritious drinks that are beneficial for health because infused water contains vitamins and minerals. Experiments with Complete Random Design (CRD), Sample code A, B and C in the analysis of vitamin levels, mineral content and acceptability. Acceptance analysis was carried out FriedmanÂ test andÂ Wilcoxon test. Vitamin and mineral levels were analyzed by ANOVA and LSD statistics. Infused water contains mineral potassium,Â calcium and magnesium and contains vitamins A and C, there are significant differences between the sample code A, B and C. Infused water containing minerals, vitamins, and accepted by the community.
DIFFERENCE OF THE IMAGE INFORMATION AXIAL PELVIC MRI USING DIFFUSION WEIGHTED IMAGE SEQUENCE WITH THE VARIATION OF B VALUE IN CERVICAL CANCER
Authors: Indrati Rini , Primadita Distyarini , Ferriastuti Widiana , Jannah Marichatul , Mulyati Sri , Daryati Siti 
Published: December 2019

Cervical cancer is the second most common type of cancer worldwide, it is reaching 15% of all kind of cancer in women. There are several ways to diagnose cervical cancer, one of them is an MRI. One of the MRI sequences which can perform the pathology of cervical cancer is Diffusion-Weighted Image. The aim of this research is to find out the anatomical differences between axial slice image of Pelvic MRI which is using DWI sequence with the variation of b value in the case of cervical cancer, and also to reveal the optimal b value to obtain the image of Pelvic MRI which is using DWI sequence in the case of cervical cancer. The method of this research is experimental with the comparison of static groups. Data is 30 images of axial DWI Pelvic MRI from 10 patientsÂ in the case of cervical cancerÂ with 3 different variations of b value, which are 600 s/mm2, 800 s/mm2, and 1000 s/mm2. Assessment of information image data done by the radiologist. Data analysis by Friedman and Wilcoxon Test. The result showed thatÂ there are differences of image information between axial Pelvic MRI which is using the DWI sequence with the variation of b value in the case of cervical cancerÂ with a significant p-value less than 0.001. Differences in image information occur in the tumor, expansion of tumor, parametrium until the pelvic wall and lymph. The optimal use of b value for axial Pelvic MRI with DWI sequence in the case of cervical cancer is 600 s/mm2.
Black rice as a functional food in Indonesia
Authors: Pratiwi Rarastoeti , Purwestri Yekti Asih 
Published: December 2019

Background: There are many local black rice cultivars in Indonesia, yet only a few of these are formally described in the literature. It has been reported that black rice has many phytochemical variants which may contribute to its use as a functional food, including nutraceuticals and secondary metabolites such as anthocyanin, oryzanol, and more. The purpose of this article was to review literature describing black rice cultivars from Indonesia, with a particular focus on its potential use as a functional food. Our literature search revealed several articles that describe black rice in relation to its nutraceutical properties and its role in reducing non-communicable diseases. Other studies describe the diversity of local pigmented rice and its potential for lowering the risk of hyperlipidemia, hyperglycemia, and for cancer prevention. Black rice has been described as a functional food in several countries; however, there is great diversity among cultivars and further research on Indonesian varieties will determine whether local variants are candidates as well for the development of functional foods. Keywords: black rice cultivar, functional food, non-communicable diseases, nutraceutical, phytochemical
Magnesium Chloride is an Effective Therapeutic Agent for Prostate Cancer
Authors: Santos Julianna Maria , Hussain Fazle 
Published: December 2019

Background: Reduced levels of magnesium can cause several diseases and increase cancer risk. Motivated by magnesium chloride’s (MgCl2) non-toxicity, physiological importance, and beneficial clinical applications, we studied its action mechanism and possible mechanical, molecular, and physiological effects in prostate cancer with different metastatic potentials.Methods: We examined the effects of MgCl2, after 24 and 48 hours, on apoptosis, cell migration, expression of epithelial mesenchymal transition (EMT) markers, and V-H+-ATPase, myosin II (NMII) and the transcription factor NF Kappa B (NFkB) expressions.Results: MgCl2 induces apoptosis, and significantly decreases migration speed in cancer cells with different metastatic potentials. MgCl2 reduces the expression of V-H+-ATPase and myosin II that facilitates invasion and metastasis, suppresses the expression of vimentin and increases expression of E-cadherin, suggesting a role of MgCl2 in reversing the EMT. MgCl2 also significantly increases the chromatin condensation and decreases NFkB expression.Conclusions: These results suggest a promising preventive and therapeutic role of MgCl2 for prostate cancer. Further studies should explore extending MgCl2 therapy to in vivo studies and other cancer types.Keywords: Magnesium chloride, prostate cancer, migration speed, V-H+-ATPase, and EMT.
L-Carnitine has a liver-protective effect through inhibition of inducible nitric oxide synthase induction in primary cultured rat hepatocytes
Authors: Nakamura Yusuke , Iida Hiroya , Nakatake Richi , Sakaguchi Tatsuma , Kaibori Masaki , Okumura Tadayoshi , Hamada Yoshinori , Doi Takashi 
Published: December 2019

Background: L-Carnitine has protective effects on various injured organs. However, it has not been reported whether L-carnitine influences the induction of inducible nitric oxide synthase (iNOS) expression during inflammation. Nitric oxide (NO) produced by iNOS is an inflammatory indicator in organs which become inflamed, including the liver.Objective: This study aimed to examine whether L-carnitine influences the induction of iNOS gene expression in inflammatory cytokine-stimulated hepatocytes and the mechanisms involved in the action. Methods: L-Carnitine was added into the primary cultures of rat hepatocytes stimulated by interleukin-1β (an in vitro liver injury model). The production of NO and induction of iNOS and its signaling pathway were analyzed.Results: Transfection experiments with iNOS promoter-luciferase constructs revealed how L-carnitine inhibited iNOS mRNA synthesis activity and reduced its stability. In support of this observation, L-carnitine reduced iNOS mRNA and iNOS protein expression levels, resulting in reduced NO production. L-Carnitine blocked two essential pathways for iNOS induction: IκB kinase (IκB degradation/NF-κB activation) and phosphatidylinositol 3-kinase/Akt (type I IL-1 receptor upregulation).Conclusions: L-Carnitine inhibited the induction of inflammatory mediator iNOS, partially through inhibition of NF-κB activation, which demonstrated L-carnitine has protective effects in an in vitro liver injury model. L-Carnitine may have therapeutic potential for organ injuries, including the liver.Keywords: L-carnitine, hepatic encephalopathy, inducible nitric oxide synthase, liver injury, primary cultured hepatocytes, nuclear factor-κB, type I interleukin-1 receptor
Mango (Mangifera indica Linn) and Anti-Inflammatory Benefits: Versatile Roles in Mitochondrial Bio-Energetics and Exercise Physiology
Authors: Swaroop Anand , Stohs Sidney J. , Bagchi Manashi , Moriyama Hiroyoshi , Bagchi Debasis 
Published: December 2019

Background: Mangoes are a popular fruit enjoyed worldwide. The mango is known for its pleasing aroma in addition to its refreshing and soothing taste. Researchers around the globe have demonstrated the diverse beneficial effects of Mangifera indica Linn in human health and disease prevention. Additionally, we should acknowledge how Ayurvedic medicine uses different parts of the mango tree. This branch of medicine has used the leaves, twigs, bark, seeds, flowers, raw and ripe fruits of mango to treat diverse degenerative diseases for thousands of years.Ethnobotany: The mango (Mangifera indica) originally came from India about 4,000 years ago. Since then, the mango has slowly spread across the world. The mango belongs to the family “Anacardiaceae” under the genus “Mangifera” and species “indica”. The mango is also referred to as “Asia’s King of Fruits” or a Royal fruit. The color of the mango fruit varies from green, yellowish green, yellow, yellowish red, orange red and red. The smell and taste of the mango fruit varies based on its state of maturity in addition to place of origin and climate. Different parts of a mango tree and mango fruit are rich in vitamins and antioxidants including vitamins B, C, E and beta-carotene, alkaloids, flavonoids, and polyphenolic compounds which include mangiferin, anthocyanins and anthocyanidins, micronutrients and essential minerals, structurally diverse carbohydrates, dietary fibers, fat, and protein. Health Benefits: Previous and current research demonstrate that the mango fruit and leaf extract, which is enriched in mangiferin and contains structurally diverse chemical constituents, are beneficial. The mango fruit and leaf extract have been shown to boost vitality, vigor, and endurance, leading to extensive application in exercise physiology. Furthermore, these constitutes ameliorate diverse degenerative disease related to metabolic syndrome, bacterial infections, gastrointestinal, and immunomodulatory disorders.Conclusions: Mango and mangiferin exhibit diverse health benefits including energy boosting, exercise performance, and human health.Keywords: Mango (Mangifera indica); mangiferin; vitamins and anthocyanins; anti-inflammatory; endurance, energy homeostasis; exercise