bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying an intersectionality lens to the Theoretical Domains Framework: a tool for thinking about how intersecting social identities and structures of power influence behaviour
Authors: Etherington Nicole , Rodrigues Isabel Braganca , Giangregorio Lora , Graham Ian D. , Hoens Alison M , Kasperavicius Danielle , Kelly Christine , Moore Julia E. , Ponzano Matteo , Presseau Justin , Sibley Kathryn M. , Straus Sharon 
Published: February 2020

Abstract
Background A key component of the implementation process is identifying potential barriers and facilitators that need to be addressed. The Theoretical Domains Framework (TDF) is one of the most commonly used frameworks for this purpose. When applying the TDF, it is critical to understand the context in which behaviours occur. Intersectionality, which accounts for the interface between social identity factors and structures of power, offers a novel approach to understanding how context shapes individual decision-making and behaviour. We aimed to develop a tool to be used alongside applications of the TDF to incorporate an intersectionality lens when identifying implementation barriers and enablers. Methods An interdisciplinary Framework Committee (n=17) prioritized the TDF as one of three models, theories, and frameworks (MTFs) to enhance with an intersectional lens through a modified Delphi approach. The modified Delphi involved two rounds of online voting followed by a final majority vote. In collaboration with the wider Framework Committee, a subgroup considered all 14 TDF domains and iteratively developed recommendations for incorporating intersectionality considerations within the and its domains TDF. An iterative approach aimed at building consensus was used to finalize recommendations. Results Consensus on how to apply an intersectionality lens to the TDF was achieved after 12 rounds of revision. Two overarching considerations for using the intersectionality-enhanced TDF were developed by the group as well as two to four prompts for each TDF domain to guide interview topic guides. Conclusions Through an expert-consensus approach, we developed a tool for applying an intersectionality lens alongside the TDF. By considering the role of intersecting social factors when selecting, tailoring, and implementing KT interventions, they may become more effective.
Validation of the Japanese Version of the Childhood Trauma Questionnaire-Short Form (CTQ-J)
Authors: Mizuki Rie , Fujiwara Takeo 
Published: February 2020

Abstract
Background In Japan, the number of child maltreatment reports has surged to almost ten folds during the last decade. Assessment tools which are concise and easy-to-use are called for, in order to facilitate the process of child maltreatment substantiation as well as to advance research on Japanese people. The Childhood Trauma Questionnaire (CTQ-SF) is accepted internationally as an instrument to assess and quantify experiences of childhood maltreatment and its impact. However, the Japanese version of CTQ-SF has not been validated. The present study examined validity of the Japanese version of the CTQ (CTQ-J). Methods The CTQ-J was administered to Japanese adolescents institutionalized due to child maltreatment and other family issues (institutionalized group, n=31) and adolescents who had no experience of institutionalization (community group, n=46) from the greater Tokyo area. Analysis of Variance was conducted to compare CTQ-J scores among the institutionalized group with documented maltreatment, the institutionalized group without documented maltreatment, and the community group, for the total score and five subscale scores. Then the discrimination of scores assessed by the CTQ-J were calculated using receiver operating characteristic (ROC) curve analysis and compared with documented childhood maltreatment experiences from institutionalized adolescents. Results Internal consistency was ‘good’ to ‘acceptable’ for the CTQ-J in the categories of emotional abuse, physical abuse, sexual abuse, and emotional neglect (Cronbach’s alpha > 0.74). In each maltreatment type, the institutionalized group with documented maltreatment experiences showed significantly higher CTQ-J scores than the community group. The area under the curve (AUC) showed higher discrimination for the total score of the CTQ-J (0.95, 95% confidence interval: 0.90-0.99), and each type of child maltreatment (all AUC: 0.98-0.86). Conclusion This study has demonstrated that the CTQ-J may be used as a reliable tool for childhood maltreatment experience assessment among Japanese adolescents. It is suggested that the CTQ-J has validity by predicting child maltreatment experiences documented in the child welfare records.
Probabilistic analysis of the controls on groundwater depth using Copula Functions
Authors: Bai Yifei , Wang Yi , Chen Yaning , Zhang Leyuan 
Published: February 2020

Abstract
Groundwater is an essential water resource in the Yarkant River Basin Irrigation District, which is the largest oasis in Xinjiang, China. This study used a novel approach to analyze the relationship between groundwater depth and three driving factors by developing Copula Functions from monthly time series data collected from 16 monitoring wells. More specifically, marginal distribution and joint distribution functions were established, and the conditional probabilities for three data ranges were calculated using both two- and three-dimensional Copula Functions. The developed statistical models showed that groundwater exploitation, runoff, and surface water irrigation significantly affected groundwater depth. The most significant effect on water table declines was associated with groundwater exploitation and lagged 1-month behind the groundwater withdrawals. The amount of runoff and irrigation were both inversely related to water table depth due to groundwater recharge. Frank Copula Functions were found to produce the best fit to the joint distribution of the variables and were used herein, allowing for the establishment of a detailed probability distribution of the change in groundwater depth under the combined effect of multiple controlling factors. The results provided key insights into how irrigation and groundwater withdrawals can be adjusted to effectively manage groundwater resources.
Anomalies and trends of high river flow under temperate climatic conditions in north-eastern Romania
Authors: Minea Ionuț , Chelariu Oana Elena 
Published: February 2020

Abstract
Regional water resource management plans include various scenarios related to the anomalies and trends of hydro-climatic parameters. Two methods are used for the identification of the anomalies and trends associated with high flow (annual and seasonal) of the rivers in Eastern Romania, namely the quantile perturbation method (QPM) and the partial trend method (PMT). These methods were selected due to the fact that they are suitable for data sets which do not rely on restrictive statistical assumption as common parametric and nonparametric trend tests do. For six of the nine stations analyzed, the decreasing trend in high extremes for annual high flow based on the PTM is the same as the annual trend obtained with the QPM. Using the PI index (associated with PTM) for the estimation of trend intensity, values between −2.280 and −9.015 m3/s were calculated for the decreasing trend of the annual high flow and between +1,633 m3/s (in autumn) and −9.940 m3/s (in summer) for the seasonal high flow. The results obtained on the anomalies and trends of high river flow may represent a starting point in the analysis of the evolution of water resources and their effective management.
Enhanced sorption capacity of the metal-dye system from water effluents by using polish activated industrial waste
Authors: Sočo Eleonora , Kalembkiewicz Jan 
Published: February 2020

AbstractThe activated coal fly ash (FA) treated with NaOH and hexadecyltrimethylammonium bromide (HDTMABr) was used as adsorbent for removal of cadmium(II) ions and rhodamine B (RB) form an aqueous solution. Characterization of FA and FA-HDTMABr were done by using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The sorption equilibrium in the system were analysed by isotherm models, such as Freundlich, Langmuir, generalized Langmiur-Freundlich, Redlich-Peterson, Jovanović, extended Jovanović, Tóth, Fumkin-Fowler-Guggenheim, Fowler-Guggenheim-Jovanović-Freundlich, Temkin, Dubinin-Radushkevich, Halsey, Brunauer Emmett and Teller. The evaluation of fitting of the isotherms studied experimentally points was carried out by means of the reduced chi-square test and the coefficient of determination. The maximum monolayer adsorption capacity of the FA-HDTMABr was found to be 744 mg·g−1 and 666 mg·g−1 for Cd(II) and RB, respectively. The PFO, PSO, Elovich mass transfer, liquid film diffusion and intra-particle diffusion models were analysed. Sorption kinetics data were well fitted by PSO model. The Elovich and intra-particle model also revealed that there are two separate stages in the sorption process, namely, the external diffusion and the inter-particle diffusion.
MiR-101 Attenuates Myocardial Infarction-induced Injury by Targeting DDIT4 to Regulate Autophagy
Authors: Li Qiulan , Gao Yanping , Zhu Jie , Jia Qingzhe 
Published: February 2020

Background:
Myocardial Infarction (MI), a kind of heart deficiency, is the main cause
of death and disability. Autophagy, a metabolic process for the degradation of damaged proteins or
organelles, is important for cardiac functions and regulated by several miRNAs including miRNA-
101. The aim of this research was to investigate the effects of miR-101 in myocardial infarctioninduced
injury and the related mechanisms.

Methods:
MI model was induced by ligation of the left coronary artery. The in vitro model was established
by hypoxia-induced H9c2 cells (rat myocardial cells). The overexpression of miR-101
was achieved by transfection. The expression of associated proteins was analyzed by Western blotting.
The level of miR-101 was analyzed by reverse transcription-polymerase chain reaction (RTPCR).
The target genes for miR-101 and the target sites were analyzed by TargetScan.

Results:
The results showed that miR-101 was decreased in MI mice (P<0.01). Autophagy and
apoptosis were increased in MI-induced injury (in vivo) and in hypoxia treated myocardial cells (in
vitro) (P<0.01). miR-101 overexpression inhibited the increase of autophagy and apoptosis in mice
and myocardial cells (P<0.01). DDIT4 was a target gene of miR-101 and expressed increasingly in
MI-induced injury mice and hypoxia treated myocardial cells. miR-101 could negatively regulate
the expression of DDIT4.

Conclusion:
This research suggested that miR-101 attenuated- MI-induced injury by targeting
DDIT4 to regulate autophagy, which indicated that miR-101 or DDIT4 may be potential therapeutic
targets for heart injury.
Syringic Acid: A Potential Natural Compound for the Management of Renal Oxidative Stress and Mitochondrial Biogenesis in Diabetic Rats
Authors: Rashedinia Marzieh , Khoshnoud Mohammad Javad , Fahlyan Bahman khalvati , Hashemi Seyedeh-Sara , Alimohammadi Mahshid , Sabahi Zahra 
Published: February 2020

Background:
Diabetic nephropathy can lead to renal diseases; oxidative stress and mitochondrial
dysfunction have critical roles in its development.

Objectives:
In this study, the effect of syringic acid (SYR), a natural phenolic acid, on diabetic
nephropathy and mitochondrial biogenesis was examined.

Methods:
Diabetes was induced in rats by injecting streptozotocin. SYR (25, 50 and 100
mg/kg/day) was orally administered for 6 weeks. SYR effects on factors, such as antioxidant activities
and mRNA expression level of mitochondrial biogenesis indexes, were evaluated.

Results:
In SYR-treated rats, blood glucose and ALP level were significantly reduced. SYR
increased kidney GSH content in the diabetic group. Elevated renal catalase and superoxide dismutase
activities in diabetic rats were restored to normal levels after treatment. SYR significantly
reduced the renal TBARS level, which had increased in diabetic rats. This compound also significantly
upregulated renal mRNA expression of PGC-1α and NRF-1, and increased mtDNA/nDNA
ratio in diabetic rats. These values were reduced in the non-treated diabetic group. The results
show improvement of histopathological damages of kidney in the SYR treated group in comparison
with the diabetic group.

Conclusion:
According to the results, SYR alters renal antioxidant defense mechanisms. Also, it
could be considered as a novel approach by targeting mitochondria in renal diabetic complications.
Lifestyle Modification with Physical Activity Promotion on Leptin Resistance and Quality of Life in Metabolic Syndrome - A Systematic Review with Meta-Analysis
Authors: Parameshwar Anche , Maiya G. Arun , Kamath Shobha Ullas , Shastry B. Ananthakrishna , Ravishankar  
Published: February 2020

Objective:
This study focused to systematically extract, summarize and analyse the data on
the effect of lifestyle modification on leptin resistance and quality of life in metabolic syndrome.

Methods:
The systematic search was done using PubMed, Cochrane Database, EMBASE, Science Direct,
CINAHL, Springer link, Web of Science from 2000-2018. English language articles and quantitative
studies focusing on leptin resistance and quality of life were included. Random effect analysis was
adopted to pool data and estimate 95% CI. The meta-analysis was done separately for leptin resistance
and quality of life which included a total of 9 studies on both RCTs and Non-RCTs.

Results:
The meta-analysis of RCTs reported insignificant effect of lifestyle modification on leptin resistance
in metabolic syndrome when compared to comparison group (-5.94(-14.28, 2.41). Two clinical
trials showed a significant effect with pooled data (5.52(2.14, 8.91). Meta-analysis of RCTs focusing on
quality of life showed significant effect on mental component (4.89 (0.16, 9.62) of quality of life (2.36
(-3.67, 8.39) when compared to comparison group.

Conclusion:
This meta-analysis suggested that lifestyle modification has a potential to improve leptin
resistance and mental component of quality of life in metabolic syndrome. However, more clearly defined
studies are required to come to a stronger conclusion.
Trace of Long Non-Coding RNAs in Signaling Pathways in Thyroid Cancer
Authors: Safaei Mohsen , Mehri-Ghahfarrokhi Ameneh , Shojaeian Ali 
Published: February 2020

Background:
Long non-coding ribonucleic acid (lncRNA) are known as similar transcripts
of messenger RNA (mRNA) whose size discrepancy is between 100 and 200 nucleotides.
Recent studies in this area have revealed that lncRNAs are involved in cancer tumorigenesis and
progression. Such molecules are transcribed from genome regions that lack open reading frame
(ORF) and fail to encode any protein. LncRNAs are characterized by tumorigenic behaviors,
which can be considered as new biomarkers. Among all types of thyroid cancer (TC), papillary
thyroid carcinoma (PTC) is the most common one.

Methods:
This review was prepared via searching of the databases of Science Direct, Directory of
Open Access Journals (DOAJ), Google Scholar, Pub-Med (NLM), Scopus, Web of Science, and
hand searching using relative keywords. The selected papers were fully reviewed and the required
information for the review was extracted and summarized.

Results:
Previous studies indicated that BRAF-activated non-protein coding RNA (BANCR) expression
had been increased in thyroid tumors compared with adjacent normal tissues.
Additionally, BANCR had mediated epithelial-mesenchymal transition (EMT) through regulating
the expression of epithelial (E)-cadherin, vimentin, and neuronal (N)-cadherin. Moreover, H19
was an example of a lncRNA that could function either as a tumor promoter or suppressor. An
important part of this study was dedicated to reviewing signaling pathways involved in TC including
extracellular-signal-regulated kinase (ERK) pathway and mitogen-activated protein kinase
(ERK/MAPK), transforming growth factor-β/ (TGF-ß)/Smads, the Janus kinase/signal transducers
and activators of transcription (JAK/STAT), P53, as well as other pathways.

Conclusion:
Briefly, this study provided an overview of the current understanding of the function
of lncRNA and micro RNAs (miRNAs) along with their interactions in TC.
Apoptotic Effects of Melittin on 4T1 Breast Cancer Cell Line is associated with Up Regulation of Mfn1 and Drp1 mRNA Expression
Authors: Moghaddam Farnaz D. , Mortazavi Pejman , Hamedi Somayeh , Nabiuni Mohammad , Roodbari Nasim H. 
Published: February 2020

Background and Purpose:
Melittin, as the main ingredient of honeybee venom, that has shown anticancer
properties. The present study aimed at investigating the cytotoxic impacts of melittin on 4T1 breast cancer
cells.

Methods:
Hemolytic activity of different concentrations (0.125, 0.25, 0.5, 1, 2, 4, 8μg/ml) of melittin was assayed
and then cytotoxicity of selected concentrations of melittin (2, 4, 8, 16, 32, and 64μg/ml), 2 and 4μg/ml of
cisplatin and 0.513, 0.295 and 0.123μg/ml of doxorubicin was evaluated on 4T1 cells using MTT assay. We
used Morphological evaluation and flow cytometric analysis was used. Real time PCR was also used to determine
mRNA expression of Mfn1 and Drp1 genes.

Results:
All compounds showed anti-proliferative effects on the tumor cell line with different potencies. Melittin
had higher cytotoxicity against 4T1 breast cancer cells (IC50= 32μg/ml-72h) and higher hemolytic activity
(HD50= 1μg/ml), as compared to cisplatin and doxorubicin. Mellitin at 16 and 32μg/ml showed apoptotic effects
on 4T1 cells according to the flow cytometric analysis. The Real time PCR analysis of Drp1 and Mfn1 expression
in cells treated with 16μg/ml of melittin revealed an up-regulation in Drp1 and Mfn1 genes mRNA expression
in comparison with control group. Treatment with 32μg/ml of melittin was also associated with a rise in
mRNA expression of Drp1 and Mfn1 as compared to the control group.

Conclusion:
The results of this study showed that melittin has anticancer effects on 4T1 cell lines in a dose and
time dependent manner and can be a good candidate for further research on breast cancer treatment.
Etika bisnis dan undang-undang anti monopoli: penangkal bisnis curang
Authors: Widihastuti Setiati 
Published: February 2020

The reality of business opportunity in New Order (ORBA) era gives only for certain businessman. The growth of private sector of during that period, in one hand be marked with biased policies lead to market distortion. In another hand, private sector of business was implication of the most of business practices unfairly. The phenomenon has been grown and supported by the connection, directly as well as indirectly, of between policy maker and businessman. this fact pushed the release of the prohibition of monopoly and unfair business practice namely UU No. 5 /1999. Relying upon merely this law to be effective in shopping monopoly, oligopoly as well as monopsony is unreal hope. Because of those practices was common among the businessman moral "guardian" such as business ethic and good purpose as complement efforts can be complemented as alternative solution.
Patients’ Experiences of Telehealth in Palliative Home Care: Scoping Review
Authors: Steindal Simen A , Nes Andréa Aparecida Goncalves , Godskesen Tove E , Dihle Alfhild , Lind Susanne , Winger Anette , Klarare Anna 
Published: February 2020

Background
Telehealth is increasingly being used in home care and could be one measure to support the needs of home-based patients receiving palliative care. However, no previous scoping review has mapped existing studies on the use of telehealth for patients in palliative home care.

Objective
The aim of this study was to map and assess published studies on the use of telehealth for patients in palliative home care.

Methods
A scoping review was conducted using the methodological framework of Arksey and O’Malley. Reporting was guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. A systematic and comprehensive search of Medical Literature Analysis and Retrieval System Online, EMBASE, PsycINFO, and Cumulative Index to Nursing and Allied Health was performed for studies published between January 2000 and October 2018. Two authors independently assessed eligibility and extracted data.

Results
The review included 22 papers from 19 studies. Four thematic groupings were identified among the included papers: easy and effortless use of telehealth regardless of the current health condition, visual features that enhance communication and care via telehealth, symptom management and self-management promotion by telehealth, and perceptions of improved palliative care at home.

Conclusions
The use of telehealth in palliative home care seems to be feasible, improving access to health care professionals at home and enhancing feelings of security and safety. The visual features of telehealth seem to allow a genuine relationship with health care professionals. However, there are contradicting results on whether the use of telehealth improves burdensome symptoms and quality of life. Future research should investigate the experiences of using telehealth among patients with life-limiting illness other than cancer and patients aged 85 years or older. More research is needed to increase the body of knowledge regarding the effectiveness of telehealth on symptoms and quality of life.
Symptom Distribution Regularity of Insomnia: Network and Spectral Clustering Analysis
Authors: Hu Fang , Li Liuhuan , Huang Xiaoyu , Yan Xingyu , Huang Panpan 
Published: February 2020

BackgroundRecent research in machine-learning techniques has led to signiﬁcant progress in various research ﬁelds. In particular, knowledge discovery using this method has become a hot topic in traditional Chinese medicine. As the key clinical manifestations of patients, symptoms play a signiﬁcant role in clinical diagnosis and treatment, which evidently have their underlying traditional Chinese medicine mechanisms.ObjectiveWe aimed to explore the core symptoms and potential regularity of symptoms for diagnosing insomnia to reveal the key symptoms, hidden relationships underlying the symptoms, and their corresponding syndromes.MethodsAn insomnia dataset with 807 samples was extracted from real-world electronic medical records. After cleaning and selecting the theme data referring to the syndromes and symptoms, the symptom network analysis model was constructed using complex network theory. We used four evaluation metrics of node centrality to discover the core symptom nodes from multiple aspects. To explore the hidden relationships among symptoms, we trained each symptom node in the network to obtain the symptom embedding representation using the Skip-Gram model and node embedding theory. After acquiring the symptom vocabulary in a digital vector format, we calculated the similarities between any two symptom embeddings, and clustered these symptom embeddings into five communities using the spectral clustering algorithm.ResultsThe top five core symptoms of insomnia diagnosis, including difficulty falling asleep, easy to wake up at night, dysphoria and irascibility, forgetful, and spiritlessness and weakness, were identified using evaluation metrics of node centrality. The symptom embeddings with hidden relationships were constructed, which can be considered as the basic dataset for future insomnia research. The symptom network was divided into five communities, and these symptoms were accurately categorized into their corresponding syndromes.ConclusionsThese results highlight that network and clustering analyses can objectively and effectively find the key symptoms and relationships among symptoms. Identification of the symptom distribution and symptom clusters of insomnia further provide valuable guidance for clinical diagnosis and treatment.