bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of Coordination between Health Care and Social Care in Multi-Professional Teamwork - the Obstacle for Coherent Care of Older People Suffering from Multi-Morbidity
Authors: Melin Emilsson Ulla , Strid Anna-Lena , Söderberg Maria 
Published: September 2020

AbstractThe lack of a cohesive health and social care is a well-known problem of significance for ageing people in general and frail older people in particular. Responsibility for organising and conducting social care and healthcare for the elderly rests on different principals in different countries but difficulties with organisational coordination and collaboration between professions and authorities in social care and healthcare is an extensive concern worldwide. Regardless of the distribution of responsibilities, collaboration and coordination structures are complex and often lead to problems. However, the gap in the coordination between different organisations and the collaboration between professions, implying that frail older people with major care needs still living in their own homes are pinched, has received hardly any recognition. By closely following an implementation project focused on teamwork in order to improve collaboration and coordination between social care and healthcare, the purpose of this article is to fill this gap with the help of an example from Sweden. Data consisted of event diaries, observations, focus groups, structured questionnaires and interviews. Findings showed that multi-professional teams certainly were established, but did not work or last. Among the obstacles found the most prominent features were the various professions’ own organisations, territorial thinking and rivalries. The whole idea of the initiative to achieve a cohesive healthcare and social care for ageing frail older people fell through. By letting this happen, not only did the project hinder the development of better practice in serving older adults, but also cemented the problematic structures it was intended to dissolve.
Validation of Puck’s failure criterion for CFRP composites in the cryogenic regime
Authors: Hohe Jörg , Schober Michael , Weiss Klaus-Peter , Appel Simon 
Published: September 2020

AbstractFor future launch vehicles, lightweight cryogenic pressure vessels are required for storage of the liquid hydrogen fuel. For their structural assessment, reliable and validated failure criteria are required. The present contribution provides an overview over the results of an ongoing research activity concerned with the validation of Puck’s composite failure criterion in the cryogenic regime. In a first step, an experimental investigation on unidirectionally fiber reinforced materials on coupon level has been performed. This test campaign has been complemented by tests on small breadboard-type specimens with an angle-ply stacking sequence. The specimens were featuring holes and tapered sections to provide stress gradients and concentrations. Test were performed at ambient temperature and in a liquid Helium environment. Puck’s failure criterion has been applied and found to provide a good prediction of first ply failure in both environments.
Movement pattern of an ellipsoidal nanoparticle confined between solid surfaces: Theoretical model and molecular dynamics simulation
Authors: Shi Junqin , Zhu Xiangzheng , Sun Kun , Fang Liang 
Published: September 2020

AbstractThe movement pattern of ellipsoidal nanoparticles confined between copper surfaces was examined using a theoretical model and molecular dynamics simulation. Initially, we developed a theoretical model of movement patterns for hard ellipsoidal nanoparticles. Subsequently, the simulation indicated that there are critical values for increasing the axial ratio, driving velocity of the contact surface, and lowering normal loads (i.e., 0.83, 15 m/s, and 100 nN under the respective conditions), which in turn change the movement pattern of nanoparticles from sliding to rolling. Based on the comparison between the ratio of arm of force (e/h) and coefficient of friction (μ) the theoretical model was in good agreement with the simulations and accurately predicted the movement pattern of ellipsoidal nanoparticles. The sliding of the ellipsoidal nanoparticles led to severe surface damage. However, rolling separated the contact surfaces and thereby reduced friction and wear.
Die Artenkenntnis von Berliner Schüler_innen am Beispiel einheimischer Vögel
Authors: Sturm Ulrike , Voigt-Heucke Silke , Mortega Kim G. , Moormann Alexandra 
Published: September 2020

ZusammenfassungDer dramatische Rückgang der Biodiversität gehört derzeit zu den größten Problemen weltweit. Das Verständnis, der Erhalt und die Förderung von Biodiversität sind eng verbunden mit Artenkenntnis. Einige Studien zeigten bereits, dass in der Gesellschaft – insbesondere auch bei jungen Menschen – die Kenntnis heimischer Arten gering ist und stetig abnimmt. Es liegen bislang noch keine Daten für Berlin vor. Wir haben daher in einer Querschnittsstudie 186 Schüler_innen der siebten Jahrgangsstufe an drei Schulen in Berlin hinsichtlich ihrer persönlichen Einschätzung der Kenntnis von acht in Berlin häufig vorkommender Vogelarten befragt und anschließend die tatsächlich vorhandene Artenkenntnis geprüft. Die Berliner Schüler_innen erkannten visuell im Mittel zwei Vogelarten und akustisch keine der getesteten Arten. Damit kann die Annahme einer geringen Artenkenntnis in Bezug auf heimische Vogelarten auch für Schüler_innen in Berlin bestätigt werden. Diese Ergebnisse zeigen, dass ein erhöhter Bedarf an der Vermittlung von Artenkenntnis besteht. Dem Erkennen und Beobachten von Tieren und Pflanzen – und damit die Wertschätzung der Vielfalt der Natur – muss mehr Bedeutung zugesprochen werden und geeignete Lernangebote weiterentwickelt und gefördert werden.
The right digital strategy for your business: an empirical analysis of the design and implementation of digital strategies in SMEs and LSEs
Authors: Becker Wolfgang , Schmid Oliver 
Published: September 2020

AbstractThe importance of digitalization continues to grow, with companies from all sectors and of various sizes subject to this influence. To remain competitive in the future, companies must recognize and overcome the opportunities and challenges of digitalization in the long term. To do this, companies can develop an entire digitization strategy that affects all areas of the business, enabling them to achieve a holistic digital transformation and ensure their survival in the digital age. Based on a qualitative–empirical research design, this study examines whether small and medium-sized enterprises (SMEs) and large enterprises (LSEs) have such a strategy, and how it is structured. In particular, it addresses the use of new technology, changes in value added, structural changes and the financing of digitalization. At the same time, there is an examination of any similarities and differences among the different company sizes.
Alternative Mitigation to Counter Resource Losses from the Lake Cumberland Drawdown, Kentucky
Authors: McCormack Valerie J. , Stackelbeck Kary 
Published: September 2020

ABSTRACTThis article presents a case study of the process of developing and implementing mitigation as the result of adverse effects to cultural resources from the drawdown of Lake Cumberland, Kentucky. Signs of a dam failure in early 2007 triggered the U.S. Army Corps of Engineers (Corps) to implement the emergency drawdown. While the drawdown prevented a life safety catastrophe, it created a new erosion zone and exposed archaeological sites to looters. When it became clear that conventional Section 106 procedures to identify and evaluate these endangered archaeological resources were not an option, alternative and creative mitigation became a necessary approach for the Corps to meet its obligations under the National Historic Preservation Act. This article discusses the creative brainstorming among the Corps, Kentucky state historic preservation officer, and tribes that led to three alternative mitigation measures aimed at educational outreach, raising public awareness, and staff training. Furthermore, the article identifies challenges encountered during the implementation of the mitigation measures. Through the presentation of our mitigation journey, we share some of our lessons learned to improve awareness of the challenges and successes one may encounter during the execution of such alternative measures.
Creative Mitigation: Alternative Strategies for Resources, Stakeholders, and the Public
Authors: Douglass John G. , Manney Shelby A. 
Published: September 2020

ABSTRACTStandard mitigation treatment for adverse effects to significant cultural resources has historically been a combination of data recovery excavation along with artifact analysis, reporting, and curation, whose purpose is to move the undertaking forward. Over the past several decades, there has been increased interest and understanding of alternative, or creative, mitigation options in these situations, which may, in the end, be the best option for the resource and more meaningful to both project stakeholders and the public. This article, the first in this special issue on creative mitigation, introduces the regulatory and conceptual framework for creative mitigation and weaves themes introduced in subsequent articles in this issue.
Aligning community-engaged research competencies with online training resources across the Clinical and Translational Science Award Consortium
Authors: Piasecki Rebecca J. , Quarles Elisa D. , Bahouth Mona N. , Nandi Anwesha , Bilheimer Alicia , Carter-Edwards Lori , Dennison-Himmelfarb Cheryl R. 
Published: September 2020

Abstract

Introduction:
The extent to which Clinical and Translational Science Award (CTSA) programs offer publicly accessible online resources for training in community-engaged research (CEnR) core competencies is unknown. This study cataloged publicly accessible online CEnR resources from CTSAs and mapped resources to CEnR core competency domains.

Methods:
Following a search and review of the current literature regarding CEnR competencies, CEnR core competency domains were identified and defined. A systematic review of publicly accessible online CEnR resources from all 64 current CTSAs was conducted between July 2018 and May 2019. Resource content was independently reviewed by two reviewers and scored for the inclusion of each CEnR core competency domain. Domain scores across all resources were assessed using descriptive statistics.

Results:
Eight CEnR core competency domains were identified. Overall, 214 CEnR resources publicly accessible online from 35 CTSAs were eligible for review. Scoring discrepancies for at least one domain within a resource initially occurred in 51% of resources. “CEnR methods” (50.5%) and “Knowledge and relationships with communities” (40.2%) were the most frequently addressed domains, while “CEnR program evaluation” (12.1%) and “Dissemination and advocacy” (11.2%) were the least frequently addressed domains. Additionally, challenges were noted in navigating CTSA websites to access CEnR resources, and CEnR competency nomenclature was not standardized.

Conclusions:
Our findings guide CEnR stakeholders to identify publicly accessible online resources and gaps to address in CEnR resource development. Standardized nomenclature for CEnR competency is needed for effective CEnR resource classification. Uniform organization of CTSA websites may maximize navigability.
Creating a centralized social media recruitment service for research teams at the University of Michigan
Authors: Doshi Aalap , Connally Lisa , Johnson Anita , Skrzypek Abbey 
Published: September 2020

Abstract
Successful social media recruitment requires specific expertise and constant upkeep, placing an inordinate burden on study teams. Over half of the study teams at the University of Michigan (U-M) surveyed about recruitment assistance needs indicated that they wanted to use social media as a recruitment strategy, but lacked the expertise to do so. We thus built a service to centralize social media recruitment across the university. This involved assembling the right expertise, creating a centralized social media profile, creating linkages to other digital recruitment platforms, building the financial structure, and operationalizing the service. So far, we have helped 94 study teams launch social media campaigns on Facebook and Instagram. These campaigns resulted in 1,653,675 users being reached, of which 20,546 users actively showed interest in participating in the corresponding studies. We followed 18 studies further, who reported a total of 345 social media participants as being enrolled, resulting in an average cost-per-contact (CPC) of $8.72 and an average cost-per-enrollee (CPE) of $55.21. The combination of communication expertise, streamlined administrative processes, and linkages to a centralized research participation registry has allowed us to help a large number of study teams seamlessly engage broad and diverse populations.
Murchison Widefield Array detection of steep-spectrum, diffuse, non-thermal radio emission within Abell 1127
Authors: Duchesne S. W. , Johnston-Hollitt M. , Zhu Z. , Wayth R. B. , Line J. L. B. 
Published: September 2020

AbstractDiffuse, non-thermal emission in galaxy clusters is increasingly being detected in low-frequency radio surveys and images. We present a new diffuse, steep-spectrum, non-thermal radio source within the cluster Abell 1127 found in survey data from the Murchison Widefield Array (MWA). We perform follow-up observations with the ‘extended’ configuration MWA Phase II with improved resolution to better resolve the source and measure its low-frequency spectral properties. We use archival Very Large Array S-band data to remove the discrete source contribution from the MWA data, and from a power law model fit we find a spectral index of –1.83±0.29 broadly consistent with relic-type sources. The source is revealed by the Giant Metrewave Radio Telescope at 150 MHz to have an elongated morphology, with a projected linear size of 850 kpc as measured in the MWA data. UsingChandraobservations, we derive morphological estimators and confirm quantitatively that the cluster is in a disturbed dynamical state, consistent with the majority of phoenices and relics being hosted by merging clusters. We discuss the implications of relying on morphology and low-resolution imaging alone for the classification of such sources and highlight the usefulness of the MHz to GHz radio spectrum in classifying these types of emission. Finally, we discuss the benefits and limitations of using the MWA Phase II in conjunction with other instruments for detailed studies of diffuse, steep-spectrum, non-thermal radio emission within galaxy clusters.
Age at menarche in Nigerian demographic surveys
Authors: Garenne Michel 
Published: September 2020

AbstractAge at menarche was investigated using data collected from demographic surveys (WFS, DHS) conducted in Nigeria between 1982 and 2018, all of which were based on large representative samples of the female population. Linear-logistic regressions were used to estimate mean age at menarche, its trends and its risk factors. Mean age at menarche had underwent a marked secular decline from 15.02 years for girls born in 1933 to 13.78 years for girls born in 2003. In multivariate analysis, height (stature), body mass index (BMI), level of education and household wealth had independent effects on age at menarche, whereas urban residence had no effect. Socioeconomic gradients were large: +9 years of schooling was associated with a –0.52 year decrease in age at menarche, and +2 standard deviations in household wealth with a –0.33 year decrease. The impact of anthropometry was even greater: +2 standard deviations in height was associated with a –0.99 year decrease in age at menarche, and +2 standard deviations in BMI with a –1.42 year decrease. Northern provinces had a higher mean age at menarche than southern provinces. Compared with independent sources, long-term trends in age at menarche, as well as their fluctuations, appeared to be correlated with trends and fluctuations in income per capita and in under-five mortality, but not with divergent trends in adult height.
Motion Control and Trajectory Planning for Obstacle Avoidance of the Mobile Parallel Robot Driven by Three Tracked Vehicles
Authors: Shentu Shuzhan , Xie Fugui , Liu Xin-Jun , Gong Zhao 
Published: September 2020

SUMMARYThis paper proposes a mobile parallel robot (MPR) and focuses on obstacle avoidance. When analyzing the collision-free trajectories, the coupling constraints caused by the parallel mechanism and the obstacle should be emphatically solved. The solution is to divide the problem into two steps. First, the genetic algorithm is employed to search and optimize the feasible trajectories under the mechanism constraint of the MPR. Then the trajectory tracking controller is designed to make the tracked vehicles move cooperatively and track a trajectory asymptotically. Finally, simulations and experiments are carried out to verify the effectiveness of the solution.
Descriptive epidemiology of coronavirus disease 2019 in Nigeria, 27 February–6 June 2020
Authors: Elimian K. O. , Ochu C. L. , Ilori E. , Oladejo J. , Igumbor E. , Steinhardt L. , Wagai J. , Arinze C. , Ukponu W. , Obiekea C. , Aderinola O. , Crawford E. , Olayinka A. , Dan-Nwafor C. , Okwor T. , Disu Y. , Yinka-Ogunleye A. , Kanu N. E. , Olawepo O. A. , Aruna O. , Michael C. A. , Dunkwu L. , Ipadeola O. , Naidoo D. , Umeokonkwo C. D. , Matthias A. , Okunromade O. , Badaru S. , Jinadu A. , Ogunbode O. , Egwuenu A. , Jafiya A. , Dalhat M. , Saleh F. , Ebhodaghe G. B. , Ahumibe A. , Yashe R. U. , Atteh R. , Nwachukwu W. E. , Ezeokafor C. , Olaleye D. , Habib Z. , Abdus-Salam I. , Pembi E. , John D. , Okhuarobo U. J. , Assad H. , Gandi Y. , Muhammad B. , Nwagwogu C. , Nwadiuto I. , Sulaiman K. , Iwuji I. , Okeji A. , Thliza S. , Fagbemi S. , Usman R. , Mohammed A. A. , Adeola-Musa O. , Ishaka M. , Aketemo U. , Kamaldeen K. , Obagha C. E. , Akinyode A. O. , Nguku P. , Mba N. , Ihekweazu C. 
Published: September 2020

Abstract
The objective of this study was to describe the epidemiology of COVID-19 in Nigeria with a view of generating evidence to enhance planning and response strategies. A national surveillance dataset between 27 February and 6 June 2020 was retrospectively analysed, with confirmatory testing for COVID-19 done by real-time polymerase chain reaction (RT-PCR). The primary outcomes were cumulative incidence (CI) and case fatality (CF). A total of 40 926 persons (67% of total 60 839) had complete records of RT-PCR test across 35 states and the Federal Capital Territory, 12 289 (30.0%) of whom were confirmed COVID-19 cases. Of those confirmed cases, 3467 (28.2%) had complete records of clinical outcome (alive or dead), 342 (9.9%) of which died. The overall CI and CF were 5.6 per 100 000 population and 2.8%, respectively. The highest proportion of COVID-19 cases and deaths were recorded in persons aged 31–40 years (25.5%) and 61–70 years (26.6%), respectively; and males accounted for a higher proportion of confirmed cases (65.8%) and deaths (79.0%). Sixty-six per cent of confirmed COVID-19 cases were asymptomatic at diagnosis. In conclusion, this paper has provided an insight into the early epidemiology of COVID-19 in Nigeria, which could be useful for contextualising public health planning.
High-metastatic cancer cells derived exosomal miR92a-3p promotes epithelial-mesenchymal transition and metastasis of low-metastatic cancer cells by regulating PTEN/Akt pathway in hepatocellular carcinoma
Authors: Yang Beng , Feng Xiaode , Liu Hua , Tong Rongliang , Wu Jingbang , Li Changbiao , Yu Hanxi , Chen Yunhao , Cheng Qiyang , Chen Junru , Cai Xianlei , Wu Wenxuan , Lu Yuejie , Hu Jiating , Liang Kejiong , Lv Zhen , Wu Jian , Zheng Shusen 
Published: September 2020

AbstractExosomes play an important role in intercellular communication and metastatic progression of hepatocellular carcinoma (HCC). However, cellular communication between heterogeneous HCC cells with different metastatic potentials and the resultant cancer progression are not fully understood in HCC. Here, HCC cells with high-metastatic capacity (97hm and Huhm) were constructed by continually exerting selective pressure on primary HCC cells (MHCC-97H and Huh7). Through performing exosomal miRNA sequencing in HCC cells with different metastatic potentials (MHCC-97H and 97hm), many significantly different miRNA candidates were found. Among these miRNAs, miR-92a-3p was the most abundant miRNA in the exosomes of highly metastatic HCC cells. Exosomal miR92a-3p was also found enriched in the plasma of HCC patient-derived xenograft mice (PDX) model with high-metastatic potential. Exosomal miR-92a-3p promotes epithelial-mesenchymal transition (EMT) in recipient cancer cells via targeting PTEN and regulating its downstream Akt/Snail signaling. Furthermore, through mRNA sequencing in HCC cells with different metastatic potentials and predicting potential transcription factors of miR92a-3p, upregulated transcript factors E2F1 and c-Myc were found in high-metastatic HCC cells promote the expression of cellular and exosomal miR-92a-3p in HCC by directly binding the promoter of its host gene, miR17HG. Clinical data showed that a high plasma exosomal miR92a-3p level was correlated with shortened overall survival and disease-free survival, indicating poor prognosis in HCC patients. In conclusion, hepatoma-derived exosomal miR92a-3p plays a critical role in the EMT progression and promoting metastasis by inhibiting PTEN and activating Akt/Snail signaling. Exosomal miR92a-3p is a potential predictive biomarker for HCC metastasis, and this may provoke the development of novel therapeutic and preventing strategies against metastasis of HCC.
EB virus-induced ATR activation accelerates nasopharyngeal carcinoma growth via M2-type macrophages polarization
Authors: Zhang Bo , Miao Tianyu , Shen Xin , Bao Lirong , Zhang Cheng , Yan Caixia , Wei Wei , Chen Jiao , Xiao Liying , Sun Chongkui , Du Jintao , Li Yan 
Published: September 2020

AbstractChronic inflammation induced by persistent viruses infection plays an essential role in tumor progression, which influenced on the interaction between the tumor cells and the tumor microenvironment. Our earlier study showed that ATR, a key kinase participant in single-stranded DNA damage response (DDR), was obviously activated by Epstein–Barr virus (EBV) in nasopharyngeal carcinoma (NPC). However, how EBV-induced ATR activation promotes NPC by influencing inflammatory microenvironment, such as tumor-associated macrophages (TAMs), remains elusive. In this study, we showed that EBV could promote the expression of p-ATR and M2-type TAMs transformation in clinical NPC specimens. The expression of p-ATR and M2-type TAMs were closely correlated each other and involved in TNM stage, lymph node metastasis and poor prognosis of the patients. In addition, the expression levels of CD68+CD206+, Arg1, VEGF, and CCL22 were increased in EB+ CNE1 cells, and decreased when ATR was inhibited. In the nude mice, EBV-induced ATR activation promoted subcutaneous transplanted tumor growth, higher expression of Ki67 and lung metastasis via M2-type TAMs recruitment. Experimental data also showed that the polarization of M2, the declined tumor necrosis factor-α (TNF-α) and increased transforming growth factor-β (TGF-β) were associated with ATR. Meanwhile, ATR activation could promote PPAR-δ and inhibited c-Jun and p-JNK expression, then downregulate JNK pathway. Collectively, our current study demonstrated the EBV infection could activate the ATR pathway to accelerate the transition of TAMs to M2, suggesting ATR knockdown could be a potential effective treatment strategy for EBV-positive NPC.