bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of silibinin on oxidative stress and microRNA-10b expression in animal models of breast cancer
Authors: Soleimani Farhad , Sharifi Rasoul , Mahmoodi Minoo , Kassaee Seyed Mehrdad 
Published: August 2020

Abstract

Background and aims
Among the factors associated with cancer are the oxidative stress and increased expression of some microRNA (miRs). Silibinin has an anti-tumor effect. Therefore, this study evaluates the effects of silibinin on oxidative stress indices and miR-10b expression in the animal models of breast cancer.

Material and methods
In this study, 48 Balb/c mice were divided into six groups (each group contains eight mice): the healthy control, the cancer control, the healthy group receiving 20 mg of silibinin, the cancer group receiving 20 mg of silibinin, the cancer group receiving 40 mg of silibinin and the cancer group receiving 80 mg of silibinin for three weeks. In order to induce cancer, 4T1 cell line was used. After obtaining breast tumor samples, the levels of Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX) and miR-10b expression in breast tumor biopsy were evaluated. Data were analyzed using one-way ANOVA, Kruskal–Wallis, Mann–Whitney and t-test (p<0.05).

Results
The use of silibinin at different doses increased the activity of SOD and GPX (significantly) and the level of TAC (significantly) in the treatment group compared to untreated cancerous mice, but mir-10b and MDA were decreased non-significant and significantly respectively.

Conclusion
Silibinin led to a non-significant reduction of miR-10b in the treatment group compared to untreated cancerous mice. Silibinin has been shown to improve oxidative stress in breast cancer mice.
Synthetic peptide vaccine for Foot-and-Mouth Disease: synthesis, characterization and immunogenicity
Authors: Mansuroğlu Banu , Derman Serap , Kızılbey Kadriye , Canım Ateş Sezen , Mustafaeva Akdeste Zeynep 
Published: August 2020

Abstract

Background
The conjugations of antigenic synthetic peptide sequences with carrier polymers have opened new possibilities for the treatment of diseases. In this study, 135–161 peptide sequence of VP1 capsid protein of Foot-and-Mouth Disease was cross-linked with P(VP-co-AA) copolymer by covalent conjugation using water-soluble carbodiimide at different ratio of components (γ=5, 7, 9, 11, 15) for the first time in the literature.

Materials and methods
Bioconjugates were characterized by gel permeation chromatography and fluorescence spectroscopy to identify occurrences of the conjugates. After characterization, γ=15 bioconjugate was determined as optimum conjugate for immunization studies and IC50 value is calculated as 1.227 mg/mL. By determining the nontoxic range, indirect ELISA were performed to evaluate the immune response elicited in balb/c mice by either peptide or P(VP-co-AA)-peptide bioconjugates (γ=15). Two injections were applied to each group and high immune responses were obtained against γ=15 conjugate compared to free peptide and control.

Results and conclusion
At the end of 9-week, the general pattern of immunoreactivity was acquired as γ=15>>peptide>control. Peptide formulated in the conjugated form had higher antibody response than free peptide and control (p<0.01, for all in both cases), this conjugate formulation put forward the adjuvant activity of P(VP-co-AA) polymer.
New ternary MgCo2Ga5 and MgNi2Ga5 gallides
Authors: Pavlyuk Nazar , Dmytriv Grygoriy , Pavlyuk Volodymyr , Rożdżyńska-Kiełbik Beata , Gil Alina , Chumak Ihor , Ehrenberg Helmut 
Published: August 2020

Abstract
The crystal structure of new isostructural compounds MgCo2Ga5 and MgNi2Ga5 has been investigated using single-crystal X-ray diffraction. Both compounds represent a new type of structure: orthorhombic, space group Pnnm, oP16, with the following lattice parameters: a = 6.2700(2) Å, b = 6.6946(2) Å, c = 6.0789(2) Å (for MgCo2Ga5) and a = 6.2693(3) Å, b = 6.6968 Å, c = 6.0794 Å (for MgNi2Ga5). The MgCo2Ga5 and MgNi2Ga5 are closely related to the tetragonal structure of CoGa3 which crystallizes in the ht-IrIn3 type. The orthorhombic structures of MgCo2Ga5 and MgNi2Ga5 are derived from CoGa3 via a translationengleiche symmetry reduction of index 2. The symmetry reduction from P42/mnm to Pnnm causes that the 4c site splits into two sites 2c and 2d. The gallium atoms together with cobalt or nickel form 3D-nets with channels, in which magnesium atoms are inserted. The formation of these polyatomic nets is confirmed by distribution of electron localization function (ELF) and charges of atoms.
Resonant interactions between the fundamental and higher harmonic of positron acoustic waves in quantum plasma
Authors: Sarkar Jit , Chandra Swarniv , Ghosh Basudev 
Published: August 2020

Abstract
In this paper, we study the second harmonic generation and its interaction with the fundamental mode in a magnetised dense positron-ion plasma interacting with laser pulses. It has been shown that different harmonics propagate with different phase velocities. The gradual evolution of the fundamental wave into higher harmonics is studied, and the conversion efficiency is calculated. Dependence of conversion efficiency on wavenumber shifts and the applied magnetic field has also been examined.
A Rapid, SuperSelective Method for Detection of Single Nucleotide Variants in Caenorhabditis elegans
Authors: Touroutine Denis , Tanis Jessica E 
Published: August 2020

Abstract
With the widespread use of single nucleotide variants generated through mutagenesis screens and genome editing technologies, there is pressing need for an efficient and low-cost strategy to genotype single nucleotide substitutions. We have developed a rapid and inexpensive method for detection of point mutants through optimization of SuperSelective (SS) primers for end-point PCR in Caenorhabditis elegans. Each SS primer consists of a 5′ “anchor” that hybridizes to the template, followed by a noncomplementary “bridge,” and a “foot” corresponding to the target allele. The foot sequence is short, such that a single mismatch at the terminal 3′ nucleotide destabilizes primer binding and prevents extension, enabling discrimination of different alleles. We explored how length and sequence composition of each SS primer segment affected selectivity and efficiency in various genetic contexts in order to develop simple rules for primer design that allow for differentiation between alleles over a broad range of annealing temperatures. Manipulating bridge length affected amplification efficiency, while modifying the foot sequence altered discriminatory power. Changing the anchor position enabled SS primers to be used for genotyping in regions with sequences that are challenging for standard primer design. After defining primer design parameters, we demonstrated the utility of SS primers for genotyping crude C. elegans lysates, suggesting that this approach could also be used for SNP mapping and screening of CRISPR mutants. Further, since SS primers reliably detect point mutations, this method has potential for broad application in all genetic systems.
Eine empirische Analyse des Nutzungsverhaltens von Sparkassenkunden zur Prognose der Kundenbindung
Authors: Zettler Julia , Schiereck Dirk 
Published: August 2020

Zusammenfassung
Die Niedrigszinsphase, die voranschreitende Regulierung und die Digitalisierung erhöhen den Margendruck bei einer stärkeren wettbewerblichen Ausrichtung des Retailbanking-Marktes. Gerade bei etablierten Finanzinstituten mit hohen Marktanteilen, wie zum Beispiel den Sparkassen, sind Informationen über mögliche Einflussparameter auf die Kundenbindung erfolgskritisch. Diese Studie analysiert den Einfluss des Produktportfolios eines privaten Kunden auf seine Kundenbindung. Besonderes Augenmerk wird zunächst auf die Begriffsschärfung der Kundenbindung gelegt. Die anschließende Analyse erfolgt über einen fundierten datenbasierten Ansatz: Resultate von State of the Art Machine Learning-Ansätzen werden mit Ergebnissen umfangreicher deskriptiver und induktiver Analysen plausibilisiert. Basis für die Untersuchung bilden Kundendaten über fünf Jahre einer mittelgroßen, deutschen Sparkasse. Unter anderem wird gezeigt, dass die Anzahl der Produkte die Art der Produkte bezogen auf die Aufrechterhaltung der Kundenbindung als Indikator dominiert.
On n-th roots of meromorphic maps
Authors: García Juan C. , Hidalgo Rubén A. 
Published: August 2020

Let S be a connected Riemann surface and let φ: S → Ĉ bebranched covering map of nite type. If n ≥ 2,then we describe a simple geometrical necessary and sucient condition for the existence of some n-th root, that is, a meromorphic map ψ: S → Ĉ such that φ = ψn.
Kemampuan Empati Anak Usia Dini
Authors: Nugraha Dadan , Apriliya Seni , Veronicha Riza Kharisma 
Published: August 2020

The ability of empathy is one of the factors that become the basis of the success of social interaction, because in that relationship it is necessary to understand the mutual understanding of feelings and help each other. This research was conducted in TK PGRI SID Sartika District Cineam which aimed to describe the empathy ability of early childhood. Subjects in this study were children aged 5-6 years, amounting to 10 children consisting of 5 boys and 5 girls.This research uses quantitative approach with descriptive research method. Data collection techniques used in this study are observation and field notes. Instruments in this research use observation sheet, field note, and documentation. The results showed that from the analysis of data of empathy ability of children aged 5-6 years in TK PGRI SID Sartika District Cineam include caring attitude, tolerance attitude, and taste grace attitude, get result that the average number of items that appear for children who are at The age range of 5-6 years is 9.5 items / descriptor, hence the average achievement achievement of empathy ability of children aged 5-6 years in TK PGRI SID Sartika District Cineam with total students aged 5-6 years 10 Children get the criteria evaluation Developed As Expectations (BSH).Kemampuan empati merupakan salah satu faktor yang menjadi dasar dari suksesnya interaksi sosial, karena dalam hubungan tersebut diperlukan adanya pengertian untuk saling memahami perasaan dan saling tolong menolong. Penelitian ini dilakukan di TK PGRI SID Sartika Kecamatan Cineam yang bertujuan untuk mendeskripsikan kemampuan empati anak usia dini. Subjek dalam penelitian ini adalah anak usia 5-6 tahun yang berjumlah 10 orang anak terdiri atas 5 orang anak laki-laki dan 5 orang anak perempuan. Penelitian ini menggunakan pendekatan kuantitatif dengan metode penelitian deskriptif. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi dan catatan lapangan. Instrumen dalam penelitian ini menggunakan lembar obsevasi, catatan lapangan, dan dokumentasi. Temuan penelitian menunjukkan bahwa dari hasil analisis data kemampuan empati anak usia 5-6 tahun di TK PGRI SID Sartika Kecamatan Cineam meliputi sikap peduli, sikap toleransi, dan sikap tenggang rasa, mendapatkan hasil bahwa rata-rata jumlah item yang muncul untuk anak yang berada pada rentang usia 5-6 tahun adalah sebanyak 9,5 item/deskriptor, maka dengan demikian diperoleh rata-rata capaian perkembangan kemampuan empati anak usia 5-6 tahun di TK PGRI SID Sartika Kecamatan Cineam dengan total siswa yang berusia 5-6 tahun sebanyak 10 orang mendapatkan kriteria penilaian Berkembang Sesuai Harapan (BSH).
ANALISIS PENERAPAN PEMBELAJARAN TERPADU PADA KELOMPOK BERMAIN (PLAY GROUP) DI TK ISLAM TIRTAYASA SERANG
Authors: Atikah Cucu 
Published: August 2020

Integrated learning has not been maximally implemented by teachers in the Islamic Kindergarten of Tirtayasa. The lack of teacher creativity in applying integrated learning and low student participation are the trigger of this research. The aim of this research was to find and analyze descriptive picture about the application of integrated learning to play group in improving various aspects of development in Islamic Kindergarten Tirtayasa Serang the results showed that integrated learning is effective enough to stimulate developmental aspects in play group, because it combines the subject matter in one theme. Aspects of these developments include aspects of moral religion, motor physical, language, cognitive and art. Penelitian ini dilatarbelakangi oleh belum dilaksanakannya pembelajaran terpadu oleh guru-guru di lingkungan TK Islam Tirtayasa secara optimal. Selain itu, minimnya kreatifitas guru dalam menerapkan pembelajaran terpadu serta partisipasi siswa yang rendah sebagai pemicunya. Tujuan yang ingin dicapai pada penelitian ini adalah untuk mengetahui dan menganalisis gambaran secara deskriptif tentang penerapan pembelajaran terpadu pada kelompok bermain dalam meningkatkan berbagai aspek perkembangan di TK Islam Tirtayasa Serang. Hasil penelitian menunjukkan bahwa pembelajaran terpadu cukup efektif untuk menstimulus aspek-aspek perkembangan pada kelompok bermain, karena memadukan materi-materi pelajaran dalam satu tema. Aspek perkembangan tersebut meliputi aspek agama, moral, fisik motorik, bahasa, kognitif, dan seni.
PERSEPSI ORANGTUA TERHADAP PENTINGNYA PROGRAM PARENTING PADA PIMPINAN ‘AISYIYAH RANTING BAMBU APUS KECAMATAN PAMULANG KOTAMADAYA TANGERANG SELATAN (2018)
Authors: Ndari Susianty Selaras , Pranawaty Rita 
Published: August 2020

ABSTRACTParents have a major role in parenting, so parents need to have knowledge in performing their role of parenting through parenting. Based on preliminary research data found the low parental involvement in the parenting program in Bambus Apus branch of Pamulang District, South Tangerang. This study aims to determine the perception of parents on the importance of parenting program on the Leaders of Twigs' Aisyiyah Bambu Apus Pamulang District Municipality of South Tangerang. While the long-term goal of this study is to increase parental involvement in the parenting program in 'Aisyiyah Bambeng Apus Sub District Pamulang Tangerang Selatan. The research was conducted by using descriptive analysis method that aims to describe the nature or characteristics of a particular phenomenon by purposive sampling approach, that is sampling based on certain targets, with the population are all members of Aisyiyah members of Bambeng Apus sub-district of Pamulang who send their children in kindergarten / PAUD 'Aisyiyah Kotamadaya Tangerang Selatan. Methods of data collection were conducted using questionnaires, documentation, structured interviews and literature study. The result of this research shows that the perception of importance of parenting activity on the leadership of Aisyiyah Tangerang Selatan is very important 24%, important 28%, quite important 48%, not important 0% and very unimportant 0%. Orangtua memiliki peran utama dalam pengasuhan anak, oleh karena itu orangtua perlu memiliki ilmu pengetahuan dalam melaksanakan perannya mengasuh anak melalaui parenting. Berdasarkan data penelitian awal ditemukan masih rendahnya keterlibatan orangtua dalam program parenting di Ranting Bambu Apus Kecamatan Pamulang Tangerang Selatan. Penelitian ini bertujuan untuk mengetahui persepsi orangtua terhadap pentingnya program parenting pada Pimpinan Ranting ‘Aisyiyah Bambu Apus Kecamatan Pamulang Kotamadya Tangerang Selatan. Sedangkan tujuan jangka panjang penelitian ini adalah untuk meningkatkan keterlibatan orangtua dalam program parenting di ‘Aisyiyah Ranting Bambu Apus Kecamatan Pamulang Tangerang Selatan. Penelitian dilakukan dengan menggunakan metode analisis deskriptif yang bertujuan untuk menguraikan sifat atau karakteristik dari suatu fenomena tertentu dengan pendekatan purposive sampling, yaitu pengambilan sampel berdasarkan target tertentu, dengan populasi adalah seluruh ibu-ibu anggota ‘ Aisyiyah Ranting Bambu Apus Kecamatan Pamulang yang menyekolahkan anaknya di TK/PAUD ‘Aisyiyah Kotamadaya Tangerang Selatan. Metode pengumpulan data dilakukan menggunakan kuisioner, dokumentasi, wawancara terstruktur serta studi pustaka. Hasil penelitian menunjukan bahwa berdasarkan hasil penelitian diperoleh data bahwa persepsi pentingnya kegiatan parenting pada pimpinan ‘Aisyiyah Tangerang Selatan sangat penting sebesar 24%, penting 28%, cukup penting 48%,tidak penting 0% dan sangat tidak penting 0%.
KEGIATAN SUPERVISI PENDIDIKAN DALAM MENUNJANG KINERJA GURU DI TK ISLAM TIRTAYASA SERANG
Authors: Atikah Cucu 
Published: August 2020

ABSTRACTSupervision activities are often conducted in the Islamic Kindergarten Tirtayasa because there is an indication of the low performance of teachers, especially newly appointed teachers. Generally lack the mastery of communication with learners and the principles of learning in TK.Tujuan want achieved in this study is to analyze and describe the activities of supervision of education in supporting the performance of teachers in the Islamic Kindergarten Tirtayasa Serang. The number of teachers in the Islamic TKT is 14 people. The results showed that the supervision of education activities conducted principals can support the performance of teachers. Kegiatan supervisi seringkali dilakukan di TK Islam Tirtayasa karena ada indikasi rendahnya kinerja guru, khususnya guru-guru yang baru diangkat. Umumnya kurang menguasai komunikasi dengan peserta didik dan prinsip-prinsip pembelajaran di TK.Tujuan yang ingin dicapai pada penelitian ini adalah untuk menganalisis dan mendeskripsikan tentang kegiatan supervisi pendidikan dalam menunjang kinerja guru di TK Islam Tirtayasa Serang. Jumlah guru di TK islam Tirtayasa 14 orang. Hasil penelitian menunjukkan bahwa kegiatan supervisi pendidikan yang dilakukan kepala sekolah dapat menunjang kinerja guru.
PERKEMBANGAN KECERDASAN INTRAPERSONAL ANAK USIA DINI KELOMPOK B TK NEGERI PEMBINA KOTO BARU KECAMATAN KUBUNG KABUPATEN SOLOK
Authors: Angela Nidia , Mulyana Edi Hendri , Nugraha Dadan 
Published: August 2020

ABSTRACT Some professional studies show that intrapersonal intelligence is one of the important intelligenceswhichto be owned and developed for the students besidethe other intelligences. Considering the importance of it, the education world should be aware about the importance of intrapersonal intelligence besides the other intelligences. The purpose of this study is to find out the intrapersonal intelligence development of children at Group B Pembina state kinderkarten Koto Baru Kubung district Solok regency. And to know the intrapersonal intelligence development of children in the self-discipline aspect, self-confidence, responsibility, expressing activities and capability to improve themselves. By using purposive sampling technique obtained data to be studied there are 15 child. The method of this research is descriptive method with qualitative approach. After analyzing the collected data, it shows that the intrapersonal intelligence development of children at group B Pembina state kinderkarten Koto Baru Kubung district Solok Regency is very good development level (BSB), because, from 15 researched childrens there are 8 childrens who achieve very good development (BSB), 5 children who achieve according to the expectations development (BSH), and 2 children with achievement levels began to grow (MB). ABSTRAK Berbagai kajian para ahli menunjukkan bahwa kecerdasan intrapersonal merupakan suatu bentuk kecerdasan yang penting dimiliki dan dikembangkan pada diri peserta didik disamping kecerdasan lainnya. Mengingat pentingnya hal tersebut, dunia pendidikan ini harus menyadari akan pentingnya kecerdasan intrapersonal disamping kecerdasan yang lainnya. Tujuan penelitian ini adalah untuk mengetahui perkembangan kecerasan intrapersonal anak kelompok B TK Negeri Pembina Koto Baru Kecamatan Kubung Kabupaten Solok. Dan untuk mengetahui perkembangan kecerdasan intrapersonal anak dalam aspek mandiri, disiplin, percaya diri, tanggungjawab, mangekspresikan kegiatan dan mampu memperbaiki diri. Dengan menggunakan teknik puposive sampling didapatkan data yang akan diteliti ada 15 orang anak. Metode yang digunakan adalah metode deskriptif dengan pendekatan kualitatif. Setelah dilakukan analisis terhadap data yang terkumpul diketahui bahwa perkembangan kecerdasan intrapersonal anak kelompok B TK Negeri Pembina Koto Baru berada pada tingkat pencapaian berkembang sangat baik (BSB), kerena dari 15 orang anak yang diteliti terdapat 8 orang anak yang berada pada tingkat pencapaian berkembang sangat baik (BSB), 5 orang anak yang berada pada tingkat pencapaian berkembang sesuai harapan (BSH), dan 2 orang anak dengan tingkat pencapaian mulai berkembang (MB).
PENGEMBANGAN MEDIA PERMAINAN SAINS FEED THE ZOO ANIMALS BERBANTU FLASH CARD UNTUK MEMFASILITASI KEMAMPUAN MENGENAL HURUF
Authors: Arifani Ghias Isqi , Mulyana Edi Hendri , Sumardi Sumardi 
Published: August 2020

The research problem was obtained through a preliminary study in the Al-Hamid Kindergarten in Tasikmalaya City, namely the difficulty of the teacher in making and developing learning media that is suitable to the needs, especially the media to recognize letters.The methode used is expansing methode type EDR from Mckenney and Reeves as generic model. Streps to do is : 1) analysis and exploration step, design and construction step, evalution and reflection step. Product constructed is learning and playing science media feed the zoo animals aided flash card. The media is specially designed for introducing letters variated with science consept. This research can only done two steps that is analysis and exploration then design and construction. The , evalution and reflection step can’t be held, remembering there’s trial and error processes due to thus Covid-19 pandemic (Coronavirus Disease 2019). Based on the results of the validation by a team of experts consisting of material experts, instructional media and pedagogics, the science game media feeds the zoo animals assisted with flash cards for further feasible use in learning in PAUD, as an alternative use of learning media that can facilitate aspects of child development only language development in particular is recognizing letters. Permasalahan penelitian didapat melalui studi pendahuluan di TK Al-Hamid Kota Tasikmalaya yaitu kesulitan guru dalam membuat dan mengembangkan media pembelajaran yang sesuai dengan kebutuhan khususnya media untuk mengenal huruf. Metode yang digunakan yaitu metode pengembangan jenis EDR (Educational Design Research) dengan model Generik dari McKenney Reeves. Tahapan-tahapan yang dilakukan yaitu 1) tahap analysis and exploration 2) tahap design and construction; 3) tahap evalution and reflection. Produk yang dihasilkan berupa media permainan sains feed the zoo animals berbantu flash card. Media permainan tersebut dirancang secara khusus untuk mengenalkan huruf yang divariasikan melalui penanaman konsep sains. Penelitian ini hanya dapat melaksanakan dua tahap yaitu tahap analisis dan eksplorasi serta desain dan konstruksi. Tahap evaluasi dan refleksi tidak dapat dilakukan, mengingat tidak akan dilakukan uji coba produk, karena adannya pandemi covid-19 (Coronavirus Disease 2019). Berdasarkan hasil validasi oleh tim ahli yang terdiri dari ahli materi, media pembelajaran serta pedagogik, media permainan sains feed the zoo animals berbantu flash card untuk selanjutnya layak digunakan dalam pembelajaran di PAUD, sebagai salah satu alternatif penggunaan media pembelajaran yang dapat memfasilitasi aspek perkembangan anak salah satunya perkembangan bahasa khususnya mengenal huruf.