bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strict deformation quantization of the state space of Mk(ℂ) with applications to the Curie–Weiss model
Authors: Landsman Klaas , Moretti Valter , van de Ven Christiaan J. F. 
Published: April 2020

Increasing tensor powers of the [Formula: see text] matrices [Formula: see text] are known to give rise to a continuous bundle of [Formula: see text]-algebras over [Formula: see text] with fibers [Formula: see text] and [Formula: see text], where [Formula: see text], the state space of [Formula: see text], which is canonically a compact Poisson manifold (with stratified boundary). Our first result is the existence of a strict deformation quantization of [Formula: see text] à la Rieffel, defined by perfectly natural quantization maps [Formula: see text] (where [Formula: see text] is an equally natural dense Poisson subalgebra of [Formula: see text]). We apply this quantization formalism to the Curie–Weiss model (an exemplary quantum spin with long-range forces) in the parameter domain where its [Formula: see text] symmetry is spontaneously broken in the thermodynamic limit [Formula: see text]. If this limit is taken with respect to the macroscopic observables of the model (as opposed to the quasi-local observables), it yields a classical theory with phase space [Formula: see text] (i.e. the unit three-ball in [Formula: see text]). Our quantization map then enables us to take the classical limit of the sequence of (unique) algebraic vector states induced by the ground state eigenvectors [Formula: see text] of this model as [Formula: see text], in which the sequence converges to a probability measure [Formula: see text] on the associated classical phase space [Formula: see text]. This measure is a symmetric convex sum of two Dirac measures related by the underlying [Formula: see text]-symmetry of the model, and as such the classical limit exhibits spontaneous symmetry breaking, too. Our proof of convergence is heavily based on Perelomov-style coherent spin states and at some stage it relies on (quite strong) numerical evidence. Hence the proof is not completely analytic, but somewhat hybrid.
Échaillon stone from France: a Global Heritage Stone Resource proposal
Authors: Dumont Thierry ,   Sauvegarde du Patrimoine Industriel d'Autrefois
Published: April 2020

Abstract
Échaillon stone, a Mesozoic platform limestone from SE France, is proposed as a Global Heritage Stone Resource. The Échaillon stone quarries are located at the western termination of the Alps, near the city of Grenoble. Stone from the main Échaillon quarries is an Upper Jurassic to Berriasian bioclastic near-reef limestone, renowned for its two characteristic white and pink colours. Two ancillary quarries nearby, the Lignet and Rovon quarries, provided the Lower Cretaceous (Barremian to Aptian) Yellow Échaillon stone, of lagoonal origin. Échaillon stone's unique characteristics, resistance to weathering and high aesthetic values made it a prized building and ornamental material used in many significant historical buildings in Europe, North Africa and the USA. Although the first use of Échaillon stone in buildings dates from the Gallo-Roman period, the industrial use ranges from the mid-nineteenth century, during the heyday of the Beaux-Arts architecture period in France, to the mid-twentieth century. The reputation of Échaillon stone was bolstered by world-renowned architects, sculptors and artists who used it for historical building ornament and sculptures. By the turn of the twentieth century, production started to decline and it ceased by the middle of that century.
Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma
Authors: Slemmons Katherine K. , Yeung Choh , Baumgart Joshua T. , Juarez Jhazeel O. Martinez , McCalla Amy , Helman Lee J. 
Published: April 2020

Abstract

Rhabdomyosarcoma is the most common childhood soft-tissue sarcoma, yet patients with metastatic or recurrent disease continue to do poorly, indicating a need for new treatments. The SRC family tyrosine kinase YES1 is upregulated in rhabdomyosarcoma and is necessary for growth, but clinical trials using single agent dasatinib, a SRC family kinase inhibitor, have failed in sarcomas. YAP1 (YES-associated protein) is highly expressed in rhabdomyosarcoma, driving growth and survival when the upstream Hippo tumor suppressor pathway is silenced, but efforts to pharmacologically inhibit YAP1 have been unsuccessful. Here we demonstrate that treatment of rhabdomyosarcoma with DNA methyltransferase inhibitor (DNMTi) upregulates Hippo activators RASSF1 and RASSF5 by promoter demethylation, activating canonical Hippo signaling and increasing inactivation of YAP1 by phosphorylation. Treatment with DNMTi decreased rhabdomyosarcoma cell growth and increased apoptosis and differentiation, an effect partially rescued by expression of constitutively active YAP (S127A), suggesting the effects of DNMTi treatment are, in part, due to Hippo-dependent inhibition of YAP1. In addition, YES1 and YAP1 interacted in the nucleus of rhabdomyosarcoma cells, and genetic or pharmacologic suppression of YES1 resulted in cytoplasmic retention of YAP1 and decreased YAP1 target gene expression, suggesting YES1 regulates YAP1 in a Hippo-independent manner. Combined treatment with DNMTi and dasatinib targeted both Hippo-dependent and Hippo-independent regulation of YAP1, ablating rhabdomyosarcoma cell growth in vitro and trending toward decreased tumor growth in vivo. These results show that the mechanisms regulating YAP1 in rhabdomyosarcoma can be inhibited by combinatorial therapy of DNMTi and dasatinib, laying the groundwork for future clinical investigations.

Significance:
This study elucidates the signaling pathways that regulate the oncogenic protein YAP1 and identifies a combination therapy to target these pathways in the childhood tumor rhabdomyosarcoma.
PD-1/PD-L1 Blockers in NSCLC Brain Metastases: Challenging Paradigms and Clinical Practice
Authors: Eguren-Santamaria Iñaki , Sanmamed Miguel F. , Goldberg Sarah B. , Kluger Harriet M. , Idoate Miguel A. , Lu Benjamin Y. , Corral Jesús , Schalper Kurt A. , Herbst Roy S. , Gil-Bazo Ignacio 
Published: April 2020

AbstractImmune checkpoint inhibitors (ICI) have revolutionized the management of advanced non–small cell lung cancer (NSCLC). However, most pivotal phase III trials systematically excluded patients with active brain metastases, precluding the generalization of the results. Although theoretically restricted from crossing the blood–brain barrier, the novel pharmacokinetic/pharmacodynamic profiles of anti-PD-1/PD-L1 drugs have prompted studies to evaluate their activity in patients with NSCLC with active central nervous system (CNS) involvement. Encouraging results have suggested that ICI could be active in the CNS in selected patients with driver-negative advanced NSCLC with high PD-L1 expression and low CNS disease burden. Single-agent CNS response rates around 30% have been reported. Beyond this particular setting, anti-PD-1/PD-L1 antibodies have been evaluated in patients receiving local therapy for brain metastases (BM), addressing concerns about potential neurologic toxicity risks associated with radiotherapy, more specifically, radionecrosis (RN). Accordingly, a variety of clinical and imaging strategies are being appropriately developed to evaluate tumor response and to rule out pseudoprogression or radionecrosis. Our purpose is to critically summarize the advances regarding the role of systemic anti-PD-1/PD-L1 antibodies for the treatment of NSCLC BM. Data were collected from the PubMed database, reference lists, and abstracts from the latest scientific meetings. Recent reports suggest anti-PD-1/PD-L1 agents are active in a subset of patients with NSCLC with BM showing acceptable toxicity. These advances are expected to change soon the management of these patients but additional research is required to address concerns regarding radionecrosis and the appropriate sequencing of local and systemic therapy combinations.
Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis
Authors: Zhang Xinbo , Ramírez Cristina M. , Aryal Binod , Madrigal-Matute Julio , Liu Xinran , Diaz Antonio , Torrecilla-Parra Marta , Suárez Yajaira , Cuervo Ana M. , Sessa William C. , Fernández-Hernando Carlos 
Published: April 2020

Objective:
Endothelial Cav-1 (caveolin-1) expression plays a relevant role during atherogenesis by controlling NO production, vascular inflammation, LDL (low-density lipoprotein) transcytosis, and extracellular matrix remodeling. Additional studies have identified cholesterol-rich membrane domains as important regulators of autophagy by recruiting ATGs (autophagy-related proteins) to the plasma membrane. Here, we investigate how the expression of Cav-1 in the aortic endothelium influences autophagy and whether enhanced autophagy contributes to the atheroprotective phenotype observed in Cav-1–deficient mice.

Approach and Results:

To analyze the impact of Cav-1 deficiency on regulation of autophagy in the aortic endothelium during the progression of atherosclerosis, we fed
Ldlr
−/−
and
Cav-1
−/−
Ldlr
−/−
mice a Western diet and assessed autophagy in the vasculature. We observe that the absence of Cav-1 promotes autophagy activation in athero-prone areas of the aortic endothelium by enhancing autophagic flux. Mechanistically, we found that Cav-1 interacts with the ATG5-ATG12 complex and influences the cellular localization of autophagosome components in lipid rafts, which controls the autophagosome formation and autophagic flux. Pharmacological inhibition of autophagy attenuates the atheroprotection observed in
Cav-1
−/−
mice by increasing endothelial inflammation and macrophage recruitment, identifying a novel molecular mechanism by which Cav-1 deficiency protects against the progression of atherosclerosis.

Conclusions:

These results identify Cav-1 as a relevant regulator of autophagy in the aortic endothelium and demonstrate that pharmacological suppression of autophagic flux in Cav-1–deficient mice attenuates the atheroprotection observed in
Cav-1
−/−
mice. Additionally, these findings suggest that activation of endothelial autophagy by blocking Cav-1 might provide a potential therapeutic strategy for cardiovascular diseases including atherosclerosis.
Prenatal and Postnatal Cardiac Development in Offspring of Hypertensive Pregnancies
Authors: Aye Christina Y. L. , Lewandowski Adam J. , Lamata Pablo , Upton Ross , Davis Esther , Ohuma Eric O. , Kenworthy Yvonne , Boardman Henry , Frost Annabelle L. , Adwani Satish , McCormick Kenny , Leeson Paul 
Published: April 2020

Background
Pregnancy complications such as preterm birth and fetal growth restriction are associated with altered prenatal and postnatal cardiac development. We studied whether there were changes related specifically to pregnancy hypertension.

Methods and Results

Left and right ventricular volumes, mass, and function were assessed at birth and 3 months of age by echocardiography in 134 term‐born infants. Fifty‐four had been born to mothers who had normotensive pregnancy and 80 had a diagnosis of preeclampsia or pregnancy‐induced hypertension. Differences between groups were interpreted, taking into account severity of pregnancy disorder, sex, body size, and blood pressure. Left and right ventricular mass indexed to body surface area (
LVMI
and
RVMI
) were similar in both groups at birth (
LVMI
20.9±3.7 versus 20.6±4.0 g/m
2
,
P
=0.64,
RVMI
17.5±3.7 versus 18.1±4.7 g/m
2
,
P
=0.57). However, right ventricular end diastolic volume index was significantly smaller in those born to hypertensive pregnancy (16.8±5.3 versus 12.7±4.7 mL/m
2
,
P
=0.001), persisting at 3 months of age (16.4±3.2 versus 14.4±4.8 mL/m
2
,
P
=0.04). By 3 months of age these infants also had significantly greater
LVMI
and
RVMI
(
LVMI
24.9±4.6 versus 26.8±4.9 g/m
2
,
P
=0.04;
RVMI
17.1±4.2 versus 21.1±3.9 g/m
2
,
P
<0.001). Differences in
RVMI
and right ventricular end diastolic volume index at 3 months, but not left ventricular measures, correlated with severity of the hypertensive disorder. No differences in systolic or diastolic function were evident.

Conclusions
Infants born at term to a hypertensive pregnancy have evidence of both prenatal and postnatal differences in cardiac development, with right ventricular changes proportional to the severity of the pregnancy disorder. Whether differences persist long term as well as their underlying cause and relationship to increased cardiovascular risk requires further study.
Japan, a Separate Province From India? Rivalries and Financial Management of Two Jesuit Missions in Asia
Authors: Vu Thanh Hélène 
Published: April 2020

Abstract
This article analyzes the organization of the Jesuit missions in Asia in the sixteenth and seventeenth centuries through the case of the relationship between the Indian mission and the Japanese mission, which was subordinate to it. It highlights the management and control methods which were specific to the Asian missions. It thus demonstrates the growing autonomy of the Japanese mission, which was trying to free itself from Indian administrative and financial supervision. In doing so, the deep-seated nature of the rivalries and tensions between missions within a single Jesuit province are brought into focus, despite Roman arbitration. The article is thus an invitation to reassess the regional dimension to Jesuit governance, which is sometimes ignored in favor of the global aspect.
Arctic Sea Ice Growth in Response to Synoptic- and Large-Scale Atmospheric Forcing from CMIP5 Models
Authors: Cai Lei , Alexeev Vladimir A. , Walsh John E. 
Published: April 2020

AbstractWe explore the response of wintertime Arctic sea ice growth to strong cyclones and to large-scale circulation patterns on the daily scale using Earth system model output in phase 5 of the Coupled Model Intercomparison Project (CMIP5). A combined metrics ranking method selects three CMIP5 models that are successful in reproducing the wintertime Arctic dipole (AD) pattern. A cyclone identification method is applied to select strong cyclones in two subregions in the North Atlantic to examine their different impacts on sea ice growth. The total change of sea ice growth rate (SGR) is split into those respectively driven by the dynamic and thermodynamic atmospheric forcing. Three models reproduce the downward longwave radiation anomalies that generally match thermodynamic SGR anomalies in response to both strong cyclones and large-scale circulation patterns. For large-scale circulation patterns, the negative AD outweighs the positive Arctic Oscillation in thermodynamically inhibiting SGR in both impact area and magnitude. Despite the disagreement on the spatial distribution, the three CMIP5 models agree on the weaker response of dynamic SGR than thermodynamic SGR. As the Arctic warms, the thinner sea ice results in more ice production and smaller spatial heterogeneity of thickness, dampening the SGR response to the dynamic forcing. The higher temperature increases the specific heat of sea ice, thus dampening the SGR response to the thermodynamic forcing. In this way, the atmospheric forcing is projected to contribute less to change daily SGR in the future climate.
The Anterolateral Triangle: Implications for a Transnasal Prelacrimal Approach to the Floor of the Middle Cranial Fossa
Authors: Li Lifeng , London Nyall R. , Prevedello Daniel M. , Carrau Ricardo L. 
Published: April 2020

Background The anterolateral triangle enclosed by the foramen rotundum and foramen ovale constitutes part of the floor of the middle cranial fossa (MCF). Objective To assess the feasibility of a transnasal prelacrimal approach for accessing the floor of MCF via an anterolateral triangle corridor and to determine the extent of maximal exposure while safeguarding neurovascular structures. Methods A transnasal prelacrimal approach was performed in 5 cadaveric specimens (10 sides). Following the identification of foramen rotundum and foramen ovale, the bony ridge between 2 was drilled to expose the MCF. The temporal lobe dura was then elevated laterally, and the distances from foramen ovale to the respective borders of the area of the MCF window were measured using a surgical navigation device. Results The MCF was exposed with a 0° scope in all specimens also exposing significant landmarks including the middle meningeal artery, greater superficial petrosal nerve, superior petrous sinus, and arcuate eminence. Average distances from foramen ovale to the anterior, posterior, and lateral exposed borders were 22.86 ± 1.87 mm, 27.24 ± 0.94 mm, and 24.23 ± 1.61 mm, respectively. The average area of exposed MCF window was 554.12 ± 60.22 mm2. Preservation of vidian nerve, greater palatine nerve, lateral nasal wall, and nasolacrimal duct was possible in all 10 sides. Conclusion It is feasible to access the floor of MCF via an endoscopic transnasal prelacrimal approach with seemingly low risk.
A PRACTICAL PRE-OPERATIVE PREDICTIVE MODEL FOR DETERMINING HAMSTRING AUTOGRAFT SIZE FOR ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION IN CHILDREN AND ADOLESCENTS
Authors: Sherman Benjamin , Kwan Kevin , Schlechter John 
Published: April 2020

Background: The most commonly used graft for pediatric/adolescent anterior cruciate ligament (ACL) reconstruction is the hamstring autograft. Recent evidence has suggested that graft sizes less than 8 mm and age less than 20 years old are the most significant factors influencing graft failure. Additionally, studies examining the role of augmenting smaller grafts with allograft have demonstrated mixed results and potentially increased failure rates. Efforts to predict hamstring size preoperatively using MRI and ultrasound in the adult population have shown promise. However, there have been no studies in an entirely pediatric population. Hypothesis/Purpose: The purpose of this study was to evaluate the predictive value of MRI in determining hamstring autograft size preoperatively for pediatric ACL reconstructions. Methods: Children and adolescents from 10-20 years old that had undergone ACL reconstruction using hamstring autograft were identified from 2017-2018. Semitendinosus and gracilis cross-sectional area and diameter were measured on preoperative knee MRIs using the field of interest and distance measurement tools. The slice used for measurement was identified as the largest section by the measuring surgeon. Two surgeons independently measured all MRIs. Preoperative demographic data (height, weight, body mass index (BMI), gender) and operative data (graft size) was collected. Ordinal regression analysis was performed to determine the relationship between demographic data and graft size. A Classification and Regression Tree (CART) was constructed to identify predictors for the pre-determined graft sizes of 8 mm. Receiver operating characteristics (ROC) analysis were then created to assess the performance of the predictive model and determine sensitivity and specificity. Results: One hundred and ten children (54 boys, 56 girls) were included in this study with an average age of 15.93 years (range 11.81-20.22) and average BMI of 25.98 (range 16.02-40.08). CART analysis determined that if the sum of the cross-sectional areas of the semitendinosus and gracilis tendons were greater than 31.17 mm then 87.5% of children had graft sizes of 8 mm or greater. The ROC analysis determined the model to have an 80% sensitivity and 74% specificity for predicting a graft size of 8 mm or larger. Conclusion: A preoperative summation of the cross-sectional areas of the semitendinosus and gracilis tendons greater than 31.17 mm predicts an intraoperative graft size of 8 mm or larger in 87.5% of children. [Table: see text][Table: see text][Figure: see text]
HOW OFTEN ARE STUDY DESIGN AND LEVEL OF EVIDENCE MISREPORTED IN THE PEDIATRIC ORTHOPAEDIC LITERATURE?
Authors: LeBrun Drake G. , Kocher Mininder S. , Baldwin Keith D. , Patel Neeraj M. 
Published: April 2020

Background: Observational studies are the most commonly employed study designs in the pediatric orthopaedic literature. The differences between observational study designs are important but not widely understood, leading to potential discrepancies between the reported and actual study design. Study design misclassification is associated with a potential for misreporting level of evidence (LOE). Purpose: To determine the degree of study design and LOE misclassification in the pediatric orthopaedic literature. Methods: The Institute for Scientific Information (ISI) Web of Science was queried to identify all pediatric orthopaedic observational studies published from 2014-2017. Reported study design and LOE were recorded for each study. The actual study design and LOE were determined based on established clinical epidemiological criteria by reviewers with advanced epidemiological training. Studies with a discrepancy between reported and actual study design and LOE were identified. The following covariates were recorded for each study: subspecialty, inclusion of a statistician coauthor, sample size, journal, and journal impact factor. Chi-square analysis was used to identify factors associated with study design and LOE misreporting. Results: One thousand articles were screened, yielding 647 observational studies. Three hundred thirty-five publications (52%) did not clearly report a study design in either the abstract or manuscript text. Of those that did, 59/312 (19%) reported the incorrect study design (Figure 1). The largest discrepancy was in the 109 studies that were reported to be case series, among which 30 (27.5%) were actually retrospective cohort studies. Three hundred thirteen publications (48%) did not report a LOE. Of those that did, 95/334 (28%) reported the incorrect LOE (Figure 2). Thirty-three studies (19%) reported a LOE that was higher than the actual LOE and 62 (35%) under-reported the LOE. Conclusion: The majority of observational pediatric orthopaedic studies either did not report a study design or reported the wrong study design. Similarly, the majority of studies did not report or misreported their LOE. Greater epidemiological rigor in classifying and evaluating observational studies is required on the part of investigators, reviewers, and journal editors. [Figure: see text][Figure: see text]