bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensory profiles in women with neuropathic pain after breast cancer surgery
Authors: Mustonen L. , Vollert J. , Rice A. S. C. , Kalso E. , Harno H. 
Published: May 2020

Abstract
Purpose
We performed a detailed analysis of sensory function in patients with chronic post-surgical neuropathic pain (NP) after breast cancer treatments by quantitative sensory testing (QST) with DFNS (German Research Network on Neuropathic Pain) protocol and bed side examination (BE). The nature of sensory changes in peripheral NP may reflect distinct pathophysiological backgrounds that can guide the treatment choices. NP with sensory gain (i.e., hyperesthesia, hyperalgesia, allodynia) has been shown to respond to Na+-channel blockers (e.g., oxcarbazepine).

Methods
104 patients with at least “probable” NP in the surgical area were included. All patients had been treated for breast cancer 4–9 years ago and the handling of the intercostobrachial nerve (ICBN) was verified by the surgeon. QST was conducted at the site of NP in the surgical or nearby area and the corresponding contralateral area. BE covered the upper body and sensory abnormalities were marked on body maps and digitalized for area calculation. The outcomes of BE and QST were compared to assess the value of QST in the sensory examination of this patient group.

Results
Loss of function in both small and large fibers was a prominent feature in QST in the area of post-surgical NP. QST profiles did not differ between spared and resected ICBN. In BE, hypoesthesia on multiple modalities was highly prevalent. The presence of sensory gain in BE was associated with more intense pain.

Conclusions
Extensive sensory loss is characteristic for chronic post-surgical NP several years after treatment for breast cancer. These patients are unlikely to respond to Na+-channel blockers.
Relocating shared automated vehicles under parking constraints: assessing the impact of different strategies for on-street parking
Authors: Winter Konstanze , Cats Oded , Martens Karel , van Arem Bart 
Published: May 2020

AbstractWith shared mobility services becoming increasingly popular and vehicle automation technology advancing fast, there is an increasing interest in analysing the impacts of large-scale deployment of shared automated vehicles. In this study, a large fleet of shared automated vehicles providing private rides to passengers is introduced to an agent-based simulation model based on the city of Amsterdam, the Netherlands. The fleet is dimensioned for a sufficient service efficiency during peak-hours, meaning that in off-peak hours a substantial share of vehicles is idle, requiring vehicle relocation strategies. This study assesses the performance of zonal pro-active relocation strategies for on-demand passenger transport under constrained curbside parking capacity: (1) demand-anticipation, (2) even supply dispersion and (3) balancing between demand and supply of vehicles. The strategies are analysed in regard to service efficiency (passenger waiting times, operational efficiency), service externalities (driven mileage, parking usage) and service equity (spatial distribution of externalities and service provision). All pro-active relocation strategies are outperformed by a naïve remain-at-drop off-location strategy in a scenario where curbside parking capacity is in abundance. The demand-anticipation heuristic leads to the highest average waiting times due to vehicle bunching at demand-hotspots which results in an uneven usage of parking facilities. The most favourable results in regard to service efficiency and equity are achieved with the heuristics balancing demand and supply, at the costs of higher driven mileage due to the relocation of idle vehicles. These results open up opportunities for municipalities to accompany the introduction of large fleets of shared automated vehicles with suitable curbside management strategies that mitigate undesired effects.
The Coconut Water Antimicrobial Peptide CnAMP1 Is Taken up into Intestinal Cells but Does Not Alter P-Glycoprotein Expression and Activity
Authors: Anaya Katya , Podszun Maren , Franco Octavio Luiz , de Almeida Gadelha Carlos Alberto , Frank Jan 
Published: May 2020

AbstractCoconut antimicrobial peptide-1 (CnAMP1) is a naturally occurring bioactive peptide from green coconut water (Cocos nucifera L.). Although biological activities have been reported, the physiological relevance of these reports remains elusive as it is unknown if CnAMP1 is taken up into intestinal cells. To address this open question, we investigated the cytotoxicity of CnAMP1 in intestinal cells and its cellular uptake into human intestinal cells. Considering the importance of the P-glycoprotein (P-gp) to the intestinal metabolism of xenobiotics, we also investigated the influence of CnAMP1 on P-gp activity and expression. Both cell lines showed intracellular fluorescence after incubation with fluorescein labelled CnAMP1, indicating cellular uptake of the intact or fragmented peptide. CnAMP1 (12.5–400 μmol/L) showed no signs of cytotoxicity in LS180 and differentiated Caco-2 cells and did not affect P-gp expression and activity. Further research is required to investigate the identity of CnAMP1 hydrolysis fragments and their potential biological activities.
Strange Bedfellows: Coordinating Medicare and Medicaid to Achieve Cost-Effective Care for Patients with the Greatest Health Needs
Authors: Elmaleh-Sachs Arielle , Schneider Eric C. 
Published: May 2020

AbstractThis perspective describes federal efforts in the United States (U.S.) to integrate care for an especially complex, vulnerable, and costly patient population: adults eligible for both Medicare and Medicaid insurance. The goal of the paper is to demystify for clinical policy leaders and practicing clinicians the origins and evolution of the Dual-Eligible Special Needs Plans (D-SNPs) recently permanently authorized by the U.S. Congress and to explore the potential for these policy changes to help such health plans improve care for the sickest and most vulnerable Americans.
Naturalizing Darwall’s Second Person Standpoint
Authors: Isern-Mas Carme , Gomila Antoni 
Published: May 2020

AbstractIn this paper, we take Darwall’s analytical project of the second-person standpoint as the starting point for a naturalistic project about our moral psychology. In his project, Darwall contends that our moral notions constitutively imply the perspective of second-personal interaction, i.e. the interaction of two mutually recognized agents who make and acknowledge claims on one another. This allows him to explain the distinctive purported authority of morality. Yet a naturalized interpretation of it has potential as an account of our moral psychology. We propose a naturalistic interpretation of Darwall’s work to address some of the main issues about our moral psychology. First, we explain why moral norms motivate us; namely, because of these second-personal relations. We provide a naturalized version of this solution. Second, we articulate how intersubjective interactions take place effectively; grounding duties to particular other subjects, and being related to distinctive moral emotions. Third, we address the question of the limits of the moral community, proposing that it comprises all agents capable of second-personal interactions. Finally, we explain the emergence of community norms through intersubjective interaction. Since all group members can adopt alternatively the second-personal stance to each other, demands are sanctioned and recognized in a triangulation process which explains the emergence of group norms.
Correction to: A Systematic Review of Methodological Variation in Healthcare Provider Perspective Tuberculosis Costing Papers Conducted in Low- and Middle-Income Settings, Using An Intervention-Standardised Unit Cost Typology
Authors: Cunnama Lucy , Gomez Gabriela B. , Siapka Mariana , Herzel Ben , Hill Jeremy , Kairu Angela , Levin Carol , Okello Dickson , DeCormier Plosky Willyanne , Garcia Baena Inés , Sweeney Sedona , Vassall Anna , Sinanovic Edina 
Published: May 2020

In the original version of this article, Fig. 3 was published in an incorrect format. The correct figure is published with this correction.
Italian nurses knowledge and attitudes towards fatigue in pediatric onco-hematology
Authors: Rostagno Elena , Bergadano Anna , Piredda Michela , De Marinis Maria Grazia 
Published: May 2020

Background and Objective:
Fatigue is one of the most debilitating and prevalent symptoms in pediatric cancer patients and it is important to know if nurses are able to recognize and manage it. The aim of this study was to investigate the knowledge and attitudes towards fatigue of nurses working in Italian pediatric onco-hematology centers.

Methods:
Cross-sectional online survey. An existing questionnaire was adapted to the Italian context, extended with a section on attitudes, and psychometrically tested. The questionnaire was sent to all nurses working in Italian pediatric onco-hematology centers.

Results:
Respondents (n = 189), who were working in 37/53 (~70%) centers, reported 42% of children and 68% of adolescents experiencing fatigue, with intensity increasing with age. Contributing factors were treatments and co-morbidities; frequent symptoms were mood changes and lack of energy. Among respondents who did not assess fatigue, 36.2% did not know an appropriate tool. Nurses recognized fatigue as an important problem and their knowledge and attitudes towards fatigue seemed satisfactory.

Conclusion:
This study provides nurses with an instrument to investigate their knowledge and attitudes about fatigue. Nurses' awareness of the significance of fatigue is a fundamental step towards improving its management and offering strategies that can help both the child and their family.
A framework for attenuation method selection evaluated with ice-penetrating radar data at South Pole Lake
Authors: Hills Benjamin H. , Christianson Knut , Holschuh Nicholas 
Published: May 2020

AbstractAll radar power interpretations require a correction for attenuative losses. Moreover, radar attenuation is a proxy for ice-column properties, such as temperature and chemistry. Prior studies use either paired thermodynamic and conductivity models or the radar data themselves to calculate attenuation, but there is no standard method to do so; and, before now, there has been no robust methodological comparison. Here, we develop a framework meant to guide the implementation of empirical attenuation methods based on survey design and regional glaciological conditions. We divide the methods into the three main groups: (1) those that infer attenuation from a single reflector across many traces; (2) those that infer attenuation from multiple reflectors within one trace; and (3) those that infer attenuation by contrasting the measured power from primary and secondary reflections. To assess our framework, we introduce a new ground-based radar survey from South Pole Lake, comparing selected empirical methods to the expected attenuation from a temperature- and chemistry-dependent Arrhenius model. Based on the small surveyed area, lack of a sufficient calibration surface and low reflector relief, the attenuation methods that use multiple reflectors are most suitable at South Pole Lake.
On the relation between ionospheric parameters and sunspot number
Authors: Hall Chris , Johnsen Magnar Gullikstad 
Published: May 2020

AbstractIn a recent study, mid-latitude ionospheric parameters were compared with solar activity; it was suggested that the relationship between these, earlier assumed stable, might be changing with time (Lastovicka, 2019). Here, the information is extended to higher latitude (69.6°N, 19.2E) and further back in time. For the ionospheric F-region (viz. the critical frequency, FoF2) the same behaviour is seen with a change-point around 1996. For the ionospheric E-region (viz. the critical frequency, foE), change-points are less obvious than in the mid-latitude study, presumably owing to the observation site lying under the auroral oval.
COVID-19 infections among HCWs exposed to a patient with a delayed diagnosis of COVID-19
Authors: Baker Meghan A. , Rhee Chanu , Fiumara Karen , Bennett-Rizzo Carin , Tucker Robert , Williams Sarah A. , Wickner Paige , Beloff Jennifer , McGrath Casey , Poulton Alexa , Klompas Michael 
Published: May 2020

AbstractWe report on COVID-19 risk among HCWs exposed to a patient diagnosed with COVID-19 on day 13 of hospitalization. There were 44 HCWs exposed to the patient before contact and droplet precautions were implemented: of these, 2 of 44 (5%) developed COVID-19 potentially attributable to the exposure.
Semi-classical solutions for Kirchhoff type problem with a critical frequency
Authors: Xie Qilin , Zhang Xu 
Published: May 2020

AbstractIn the present paper, we consider the following Kirchhoff type problem$$ -\Big(\varepsilon^2+\varepsilon b \int_{\mathbb R^3} | \nabla v|^2\Big) \Delta v+V(x)v=|v|^{p-2}v \quad {\rm in}\ \mathbb{R}^3, $$whereb> 0,p∈ (4, 6), the potential$V\in C(\mathbb R^3,\mathbb R)$andɛis a positive parameter. The existence and multiplicity of semi-classical state solutions are obtained by variational method for this problem with several classes of critical frequency potentials, i.e.,$\inf _{\mathbb R^N} V=0$. As to Kirchhoff type problem, little has been done for the critical frequency cases in the literature, especially the potential may vanish at infinity.
Winter climate change on the northern and southern Antarctic Peninsula
Authors: Evtushevsky Oleksandr M. , Kravchenko Volodymyr O. , Grytsai Asen V. , Milinevsky Gennadi P. 
Published: May 2020

AbstractDifferences in the decadal trend in the winter surface temperature in the northern and southern Antarctic Peninsula have been analysed. Time series from the two stations Esperanza and Faraday/Vernadsky since the early 1950s are used. The two time series are strongly correlated only during the 1980s and 1990s when their variability and trends are associated with both the Niño-4 region and Southern Annular Mode impacts. The winter cooling at the Faraday/Vernadsky station contrasts with the winter warming at the Esperanza station during the period of 2006–17. The different temperature trends are accompanied by weak correlations between the temperatures at these two stations. Linearly congruent components of the station temperature trends in 2006–17 indicate a dominant contribution of Southern Annular Mode (tropical sea surface temperature anomalies) to warming (cooling) in the northern (southern) Peninsula. Distinctive impacts of climate modes are observed in combination with the recent deepening of the negative sea-level pressure anomaly to the west of the peninsula and the related change in the zonal and meridional wind components. These factors apparently contribute to the occurrence of the boundary that crosses the peninsula and divides it into sub-regions with warming and cooling.
Nutrition composition of children’s meals in twenty-six large US chain restaurants
Authors: Dunn Caroline G , Vercammen Kelsey A , Frelier Johannah M , Moran Alyssa J , Bleich Sara N 
Published: May 2020

AbstractObjective:To compare the nutritional quality of children’s combination meals offered at large US chain restaurants characterised by three versions – default (advertised), minimum (lower-energy) and maximum (higher-energy).Design:We identified default children’s meals (n 92) from online restaurant menus, then constructed minimum and maximum versions using realistic additions, substitutions and/or portion size changes for existing menu items. Nutrition data were obtained from the MenuStat database. Bootstrapped linear models assessed nutrition differences between meal versions and the extent to which meal components (main dish, side dish, beverage) drove differences across versions. For each version, we examined the proportion of meals meeting the Guidelines for Responsible Food Marketing to Children.Setting:Twenty-six fast-food and fast-casual restaurants, in 2017.Participants:None.Results:Nutrient values differed significantly across meal versions for energy content (default 2443 kJ (584 kcal), minimum 1674 kJ (400 kcal), maximum 3314 kJ (792 kcal)), total fat (23, 17, 33 g), saturated fat (8, 6, 11 g), Na (1046, 915, 1287 mg) and sugar (35, 14, 51 g). The substitution of lower-energy beverages resulted in the greatest reduction in energy content (default to minimum, −418 kJ (−100 kcal)) and sugar (−20 g); choosing lower-energy side dishes resulted in the greatest reduction in total fat (default to minimum, −4 g), saturated fat (−1·1 g) and Na (−69 mg). Only 3 % of meals met guidelines for all nutrients.Conclusions:Realistic modifications to children’s combination meals using existing menu options can significantly alter a meal’s nutrient composition. Promoting lower-energy items as the default option, especially for beverages and side dishes, has a potential to reduce fat, saturated fat and/or sugar in children’s meals.
PATCHING AND THE COMPLETED HOMOLOGY OF LOCALLY SYMMETRIC SPACES
Authors: Gee Toby , Newton James 
Published: May 2020

AbstractUnder an assumption on the existence of $p$-adic Galois representations, we carry out Taylor–Wiles patching (in the derived category) for the completed homology of the locally symmetric spaces associated with $\operatorname{GL}_{n}$ over a number field. We use our construction, and some new results in non-commutative algebra, to show that standard conjectures on completed homology imply ‘big $R=\text{big}~\mathbb{T}$’ theorems in situations where one cannot hope to appeal to the Zariski density of classical points (in contrast to all previous results of this kind). In the case where $n=2$ and $p$ splits completely in the number field, we relate our construction to the $p$-adic local Langlands correspondence for $\operatorname{GL}_{2}(\mathbb{Q}_{p})$.
Intraocular Pressure Reactivity to Social Stressors
Authors: Sanz Antoni , Méndez-Ulrich Jorge Luis 
Published: May 2020

Abstract. A field study was carried out in an optometry clinic, aimed at assessing the role of perceived control and aversiveness of non-contact tonometry in intraocular pressure (IOP) reactivity to psychosocial stressors, and analyzing the covariation with cardiovascular and affective reactivity. Forty-four customers volunteered to participate in the study. Perceived control (self-efficacy and threat) was assessed at the onset. IOP, systolic and diastolic blood pressure, heart rate, affect, and aversiveness of the IOP measurement procedure were assessed throughout five phases with a mean duration for each phase of 9 min: arrival, optometry, baseline, stressor task (speech in public task), and recovery. The results suggest that IOP decreases over time and the stressor task induced a remarkable reactivity in all the physiological variables assessed. The interaction between self-efficacy and threat partially explains individual variability in IOP: a high threat combined with a high self-efficacy yielded higher reactivity in IOP or increased tonic values throughout the phases. The aversiveness of the measurement procedure did not affect IOP. Intraocular Pressure (IOP) is reactive to social stressors and perceived control partially explains individual variability. Cardiovascular and IOP reactivity are parallel phenomena but do not share a common regulatory mechanism.
A Long‐Lived Sharp Disruption on the Lower Clouds of Venus
Authors: Peralta J. , Navarro T. , Vun C. W. , Sánchez‐Lavega A. , McGouldrick K. , Horinouchi T. , Imamura T. , Hueso R. , Boyd J. P. , Schubert G. , Kouyama T. , Satoh T. , Iwagami N. , Young E. F. , Bullock M. A. , Machado P. , Lee Y. J. , Limaye S. S. , Nakamura M. , Tellmann S. , Wesley A. , Miles P. 
Published: May 2020

AbstractPlanetary‐scale waves are thought to play a role in powering the yet unexplained atmospheric superrotation of Venus. Puzzlingly, while Kelvin, Rossby, and stationary waves manifest at the upper clouds (65–70 km), no planetary‐scale waves or stationary patterns have been reported in the intervening level of the lower clouds (48–55 km), although the latter are probably Lee waves. Using observations by the Akatsuki orbiter and ground‐based telescopes, we show that the lower clouds follow a regular cycle punctuated between 30°N and 40°S by a sharp discontinuity or disruption with potential implications to Venus's general circulation and thermal structure. This disruption exhibits a westward rotation period of ∼4.9 days faster than winds at this level (∼6‐day period), alters clouds' properties and aerosols, and remains coherent during weeks. Past observations reveal its recurrent nature since at least 1983, and numerical simulations show that a nonlinear Kelvin wave reproduces many of its properties.
Ecophysiology of nickel hyperaccumulating plants from South Africa – from ultramafic soil and mycorrhiza to plants and insects
Authors: Mesjasz-Przybyłowicz Jolanta , Przybyłowicz Wojciech J 
Published: May 2020

AbstractAn overview of 30 years of studies related to South African nickel hyperaccumulators is presented. Only five species have so far been identified as Ni hyperaccumulator plants among very rich and diversified South African flora. All of them occur on soils derived from ultramafic (serpentine) rocks and belong to the family Asteraceae: Berkheya coddii Roessler, Berkheya zeyheri subsp. rehmannii var. rogersiana, Berkheya nivea, Senecio coronatus, Senecio anomalochrous. Several techniques and methods were used to investigate ecophysiological aspects of the Ni hyperaccumulation phenomenon, from basic field and laboratory studies, to advanced instrumental methods. Analysis of elemental distribution in plant parts showed that in most cases the hyperaccumulated metal was stored in physiologically inactive tissues such as the foliar epidermis. However, an exception is Berkheya coddii, which has a distinctly different pattern of Ni distribution in leaves, with the highest concentration in the mesophyll. Such a distribution suggests that different physiological mechanisms are involved in the Ni transport, storage location and detoxification, compared to other hyperaccumulator species. Berkheya coddii is a plant with high potential for phytoremediation and phytomining due to its large biomass and potentially high Ni yield, that can reach 7.6% of Ni in dry mass of leaves. Senecio coronatus is the only known hyperaccumulator with two genotypes, hyperaccumulating and non-hyperaccumulating, growing on Ni-enriched/metalliferous soil. Detailed ultrastructural studies were undertaken to characterize specialized groups of cells in the root cortex of Ni-hyperaccumulating genotype, that are not known from any other hyperaccumulator. The occurrence of arbuscular mycorrhiza (AM) in Ni-hyperaccumulating plants was found for the first time in South African hyperaccumulator plants, and this type of symbiosis has been proved obligatory in all of them. There is a significant influence of mycorrhiza on the concentration and distribution of several elements. Three highly specialized herbivore insects feeding only on Ni hyperaccumulator plants were identified: Chrysolina clathrata (formerly Chrysolina pardalina), Epilachna nylanderi and Stenoscepa sp. The Ni-elimination strategies of these specialised insects have been established. Microbiological studies have revealed several genera of fungi and bacteria isolated from B. coddii leaves as well as presence of specialised, Ni-resistant yeasts in the C. clathrata gut. Understanding ecophysiological response to harsh environment broadens our knowledge and can have practical applications in cleaning polluted environments through phytomining/agromining. Finally, conservation aspects are also discussed and lines for future research are proposed.