bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved time to treatment failure and survival in ibrutinib-treated malignancies with a pharmaceutical care program: an observational cohort study
Authors: Zerbit Jeremie , Chevret Sylvie , Bernard Sophie , Kroemer Marie , Ablard Charlotte , Harel Stephanie , Brice Pauline , Madelaine Isabelle , Thieblemont Catherine 
Published: June 2020

AbstractIbrutinib treatment has been shown to increase survival in patients with B cell malignancies. Real-life data suggest a large part of discontinuations are due to toxicities, impairing ibrutinib efficacy. We aimed to assess the impact of a pharmaceutical care program on the efficacy and safety of ibrutinib. This single-center, cohort, observational study enrolled patients with B cell malignancies. Patients were either assigned to the program or to receive usual care, based on physician decision. The program was conducted by clinical pharmacists specializing in oncology and included patient education for management of toxicities, adherence monitoring, interventions to reduce drug-drug interactions, and follow-up of transition from hospital to community. Between February 2014 and May 2017, we enrolled 155 patients, including 42 (27%) who were allocated to the program group and 113 (73%) to the usual care group. The effect of the program was beneficial in terms of time to treatment failure (p = 0.0005). The 30-month progression-free and overall survivals were significantly superior in the program group (respectively p = 0.002 and p = 0.004). Grade 3 or higher adverse events occurred more frequently for patients in the usual care group (15%) than program group (8%). A pharmaceutical care program provides a personalized environment for outpatient monitoring and control of the key risks associated with oral anticancer agents. This study shows evidence that management of ibrutinib treatment by clinical pharmacists results in significant improvement in survival and better tolerance than usual care.
Empfehlungen zur Unterstützung von belasteten, schwerstkranken, sterbenden und trauernden Menschen in der Corona-Pandemie aus palliativmedizinischer Perspektive
Authors: Münch Urs , Müller Heidi , Deffner Teresa , von Schmude Andrea , Kern Martina , Kiepke-Ziemes Susanne , Radbruch Lukas 
Published: June 2020

ZusammenfassungDie mit der Corona-Pandemie einhergehenden Einschränkungen und Verbote sorgen für psychische, soziale und spirituelle Belastungen bei Patient*innen mit COVID-19, ihren Zugehörigen und den behandelnden Mitarbeitenden im Gesundheitswesen. Patient*innen mit COVID-19 dürfen nicht von ihren Zugehörigen besucht werden, in vielen Krankenhäusern und Pflegeeinrichtungen gelten generelle Besuchsverbote. Viele Unterstützungsangebote sind verringert oder ganz eingestellt worden. Bei anderen Patient*innen mit sehr kritischen und/oder lebenslimitierenden Erkrankungen werden notwendige Behandlungsmaßnahmen aufgeschoben, weil die Ressourcen im Krankenhaus für an COVID-19 Erkrankte freigehalten werden. Diese Menschen bedürfen jedoch des Gefühls der sozialen Verbundenheit mit ihren Zugehörigen. Für Palliativpatienten sollten Ausnahmen von Besuchsverboten ermöglicht werden. Besuche bei Sterbenden sind mit entsprechenden Schutzmaßnahmen auch auf Isolier- oder Intensivstationen möglich. Für isolierte Patient*innen sollten alternative Möglichkeiten überprüft werden, zum Beispiel via Videotelefonie oder über soziale Medien. Nach dem Versterben sollte den Angehörigen unter ausreichenden Schutzmaßnahmen ein Abschiednehmen ermöglicht oder alternative reale oder virtuelle Wege zum Erinnern und Gedenken angeboten werden. Die Mitarbeitenden in den Behandlungsteams sollten kontinuierlich in der Bewältigung der besonderen Belastungen unterstützt werden. Dazu ist neben klaren Kommunikations- und Entscheidungsstrukturen, Kommunikationsschulungen und psychosozialer Unterstützung vor allem die Bereitstellung der bestmöglichen Rahmenbedingungen für die Arbeit erforderlich.
Chemical modification of the polymer of intrinsic microporosity PIM-1 for enhanced hydrogen storage
Authors: Tian Mi , Rochat Sébastien , Fawcett Hamish , Burrows Andrew D. , Bowen Christopher R. , Mays Timothy J. 
Published: June 2020

AbstractA detailed investigation has been carried out of the pre-polymerisation modification of the polymer of intrinsic microporosity PIM-1 by the addition of two methyl (Me) groups to its spirobisindane unit to create a new chemically modified PIM-1 analogue, termed MePIM. Our work explores the effects of this modification on the porosity of PIM-1 and hence on its gas sorption properties. MePIM was successfully synthesised using either low (338 K) or high (423 K) temperature syntheses. It was observed that introduction of methyl groups to the spirobisindane part of PIM-1 generates additional microporous spaces, which significantly increases both surface area and hydrogen storage capacity. The BET surface area (N2 at 77 K) was increased by ~ 12.5%, resulting in a ~ 25% increase of hydrogen adsorption after modification. MePIM also maintains the advantages of good processability and thermal stability. This work provides new insights on a facile polymer modification that enables enhanced gas sorption properties.
#ItsNotInYourHead: A Social Media Campaign to Disseminate Information on Provoked Vestibulodynia
Authors: Brotto Lori A. , Nelson Melissa , Barry Lana , Maher Ciana 
Published: June 2020

AbstractProvoked Vestibulodynia (PVD) is a type of localized vulvodynia (or pain in the vulva). The estimated prevalence of this condition is about 12% of the general population and approximately 20% of women under the age of 19. Many women who live with PVD suffer in silence for years before receiving a diagnosis. Whereas cognitive behavioral therapy (CBT) was already known to be effective for managing symptoms of PVD, there has recently been a published head-to-head comparison of CBT versus mindfulness-based therapy for the primary outcome of pain intensity with penetration. The trial revealed that both treatments were effective and led to statistically and clinically meaningful improvements in sexual function, quality of life, and reduced genital pain, with improvements retained at both 6- and 12-month follow-ups. We then undertook an end-of-grant knowledge translation (KT) campaign focused on the use of social media to disseminate an infographic video depicting the findings. Social media was strategically chosen as the primary mode of dissemination for the video as it has broad reach of audience, the public can access information on social media for free, and it presented an opportunity to provide social support to the population of women with PVD who are characterized as suffering in silence by starting a sensitive and empowering dialogue on a public platform. In this paper, we summarize the social media reach of our campaign, describe how and why we partnered with social media influencers, and share lessons learned that might steer future KT efforts in this field.
Effect of substrate type on diatom-based water quality assessments in the Mount Lofty Ranges, South Australia
Authors: Richards Jenny , Tibby John , Barr Cameron , Goonan Peter 
Published: June 2020

AbstractDiatoms have been widely used in stream health assessments as they are highly sensitive to water quality. There is no standardised method for diatom-based stream health assessments causing many substrates, both natural and artificial, to be used. Few studies have investigated the impact of substrate type on diatom assemblages in streams with highly variable water levels. To determine if the substrate type affects these assessments, diatoms were analysed from an artificial substrate (rope), rock and mud, from 17 sites in the Mount Lofty Ranges, South Australia. Rope has been advocated as a substrate as it mimics aquatic plants, while having advantages of artificial substrates (e.g. standardised habitat). We found that substrate type did not affect the stream health assessment based on the Diatom Species Index for Australian Rivers and hence the additional cost of deploying ropes in such studies is unlikely to be warranted. However, substrate type influenced diatom–nutrient relationships, with no relationship between nutrients in the stream water and diatoms in the mud substrate—possibly due to the nutrient subsidy provided by mud. Therefore, by contrast, the absence of nutrients provided by the rope substrate indicates it is suited to studies of nutrient status and sensitivity in streams.
First experiments with a laser ablation source at the COALA setup
Authors: Renth Laura , Imgram Phillip , Krämer Jörg , König Kristian , Lellinger Tim , Maaß Bernhard , Müller Patrick , Ratajczyk Tim , Nörtershäuser Wilfried 
Published: June 2020

AbstractA laser ablation ion source has been built and tested at the COALA beamline. Time-of-flight measurements for various elements are sufficiently accurate to confirm the production of the intended ion species. Furthermore, the isotope shift between 40Ca+ and 44Ca+ has been determined on these bunched beams by collinear laser spectroscopy and compared to previous measurements. The frequency of the $4s{}{}^{2}\textit {S}_{1/2} \rightarrow 4p{}{}^{2}\textit {P}_{1/2}$
4
s

2

S

1
/
2

→
4
p

2

P

1
/
2

transition has been determined to $\nu ^{\mathrm {D1}}_{0}=755 222 766.8(15)$

ν

0

D
1

=
755222766.8
(
15
)
MHz for 40Ca+, as well as the corresponding isotope shift of 44Ca+ to 848.1(23) MHz. This is in a good agreement to more accurate measurements performed in a recent ion trap experiment and demonstrates the strength of the collinear-anticollinear approach to reduce systematic effects caused by the broad velocity distribution generated in the ablation process.
An in-depth investigation of student information gathering meetings with stakeholders and domain experts
Authors: Loweth Robert P. , Daly Shanna R. , Hortop Amy , Strehl Elizabeth A. , Sienko Kathleen H. 
Published: June 2020

AbstractInformation gathering activities in engineering design projects play an important role in the identification and definition of stakeholder needs and requirements. However, few studies have explored how students gather information from stakeholders and domain experts in capstone design settings. In this study, we analyzed audio recordings from 19 information gathering meetings submitted by six capstone design teams to investigate how student designers gathered information during these meetings. Our findings include 22 information gathering behaviors that student design teams exhibited during their meetings, half of which were more similar to recommended best practices for information gathering and half of which were less similar. Our findings, including the list of behaviors and associated examples, may be used to guide student designers in employing effective information gathering approaches.
Presentist History for Pluralist Science
Authors: Chang Hasok 
Published: June 2020

AbstractBuilding on my previous writings on presentism, pluralism, and “complementary science”, I develop an activist view of historiography. I begin by recognizing the inevitability of presentism. Our own purposes and perspectives do and should guide the production of our accounts of the past; like funerals, history-writing is for the living. There are different kinds of presentist history, depending on the historians’ purposes and perspectives. My particular inclination is pluralist. Science remembers its own history from a particular perspective (“whiggism”), which views the past as imperfect versions of the present; if professional historians of science shared this perspective, our work would be redundant. Instead, we can make it our task to illuminate the aspects of the past of science that scientists themselves tend to ignore and forget. History of science can also take a more productive role in the creation and improvement of scientific knowledge. Scientific progress as we know it tends to involve the shutting down of alternative paths of inquiry, resulting in a loss of potential and actual knowledge. A critical and sympathetic engagement with the past allows us to recover the lost paths, which can also suggest new paths. These points will be illustrated by a number of examples, especially from the history of chemistry and physics, including the recovery and extension of past experiments.
Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations
Authors: Kirkby Melissa , Hutton Aaron R.J. , Donnelly Ryan F. 
Published: June 2020

AbstractThe success of protein, peptide and antibody based therapies is evident - the biopharmaceuticals market is predicted to reach $388 billion by 2024 [1], and more than half of the current top 20 blockbuster drugs are biopharmaceuticals. However, the intrinsic properties of biopharmaceuticals has restricted the routes available for successful drug delivery. While providing 100% bioavailability, the intravenous route is often associated with pain and needle phobia from a patient perspective, which may translate as a reluctance to receive necessary treatment. Several non-invasive strategies have since emerged to overcome these limitations. One such strategy involves the use of microneedles (MNs), which are able to painlessly penetrate the stratum corneum barrier to dramatically increase transdermal drug delivery of numerous drugs. This review reports the wealth of studies that aim to enhance transdermal delivery of biopharmaceutics using MNs. The true potential of MNs as a drug delivery device for biopharmaceuticals will not only rely on acceptance from prescribers, patients and the regulatory authorities, but the ability to upscale MN manufacture in a cost-effective manner and the long term safety of MN application. Thus, the current barriers to clinical translation of MNs, and how these barriers may be overcome are also discussed.
Overcoming the modal/amodal dichotomy of concepts
Authors: Michel Christian 
Published: June 2020

AbstractThe debate about the nature of the representational format of concepts seems to have reached an impasse. The debate faces two fundamental problems. Firstly, amodalists (i.e., those who argue that concepts are represented by amodal symbols) and modalists (i.e., those who see concepts as involving crucially representations including sensorimotor information) claim that the same empirical evidence is compatible with their views. Secondly, there is no shared understanding of what a modal or amodal format amounts to. Both camps recognize that the two formats play essential roles in higher cognition, leading to an increasing number of hybrid proposals. In this paper, I argue that the existence of those fundamental problems should make us suspicious about a modal/amodal dichotomy. Also, I suggest that hybrid approaches, as they currently stand, do not provide suitable solutions to the impasse. Instead, we should overcome the dichotomy and treat the modal/amodal distinction as a graded phenomenon. I illustrate this hypothesis with an example of a cognitive-computational model of concepts based on the Predictive Processing framework.
Reference architecture design for farm management information systems: a multi-case study approach
Authors: Tummers J. , Kassahun A. , Tekinerdogan B. 
Published: June 2020

AbstractOne of the key elements of precision agriculture is the farm management information system (FMIS) that is responsible for data management, analytics and subsequent decision support. Various FMISs have been developed to support the management of farm businesses. A key artefact in the development of FMISs is the software architecture that defines the gross level structure of the system. The software architecture is important for understanding the system, analysing the design decisions and guiding the further development of the system based on the architecture. To assist in the design of the FMIS architecture, several reference architectures have been provided in the literature. Unfortunately, in practice, it is less trivial to derive the application architecture from these reference architectures. Two underlying reasons for this were identified. First of all, it appears that the proposed reference architectures do not specifically focus on FMIS but have a rather broad scope of the agricultural domain in general. Secondly, the proposed reference architectures do not seem to have followed the proper architecture documentation guidelines as defined in the software architecture community, lack precision, and thus impeding the design of the required application architectures. Presented in this article is a novel reference architecture that is dedicated to the specific FMIS domain, and which is documented using the software architecture documentation guidelines. In addition, the systematic approach for deriving application architectures from the proposed reference architecture is provided. To illustrate the approach, the results of multi-case study research are shown in which the presented reference architecture is used for deriving different FMIS application architectures.
Signaling probabilities in ambiguity: who reacts to vague news?
Authors: Vinogradov Dmitri , Makhlouf Yousef 
Published: June 2020

AbstractAmbiguity affects decisions of people who exhibit a distaste of and require a premium for dealing with it. Do ambiguity-neutral subjects completely disregard ambiguity and react to any vague news? Online vending platforms often attempt to affect buyer’s decisions by messages like “20 people are looking at this item right now” or “The average score based on 567 reviews is 7.9/10”. We augment the two-color Ellsberg experiment with similarly worded signals about the unknown probability of success. All decision-makers, including ambiguity-neutral, recognize and account for ambiguity; ambiguity-neutral subjects are less likely to respond to vague signals. The difference between decisions of ambiguity-neutral and non-neutral subjects vanishes for high precision signals; still less than 60% subjects choose the ambiguous urn, even for high communicated probabilities of success. We conjecture participants may discard information, if they see no contradiction between it and their prior beliefs, hence the latter are not updated. Higher confidence makes subjects more likely to discard the news, and empirically ambiguity-neutral subjects appear more confident than those ambiguity-averse.
Characterization of the Constitutive Behavior of a Cathode Active Layer in Lithium-Ion Batteries Using a Bending Test Method
Authors: Gupta P. , Üçel İ. B. , Gudmundson P. , Olsson E. 
Published: June 2020

AbstractPresently used experimental techniques for the characterization of tensile and compressive behavior of active layers in lithium-ion batteries have limitations of different kinds. This is particularly true for measurements of compressive properties. Furthermore, the characterizations of time-dependent stress-strain behavior are largely missing. In order to characterize the stress-strain relationship for a dry cathode active layer in lithium-ion batteries, a mechanical testing method is presented that previously has been applied to the testing of optical fibers. The method is based on U-shaped bending of single-side coated aluminum foils, which enables separate measurements of tensile and compressive properties. In particular, the method has clear advantages for measurements of compressive properties in comparison to previously reported techniques. Relaxation experiments are also conducted in order to characterize the time-dependent properties of the dry active layer and to check if these effects could explain the measured hysteresis. It is found that the elastic modulus in compression is significantly larger than the elastic modulus in tension and that the compressive modulus increases with strain level. Contrary, the tensile modulus is approximately independent of strain. Furthermore, hysteresis effects are present at loading-unloading measurements, both for tension and compression. The low values of the measured elastic moduli show that the electrode properties are largely controlled by the binder and carbon additives. It is concluded that the development of particle-particle contacts most likely is the reason for the higher modulus in compression in comparison to tension. The time-dependent effects are significant, primarily for shorter time scales, which explains the relaxation behavior, but they cannot fully explain the hysteresis effects. Most likely non-linear micro-mechanisms do contribute as well.
Die Perspektive von Kindern auf aktiven Transport: Ergebnisse einer qualitativen Studie zur Erfassung der Bedürfnisse von Grundschulkindern
Authors: Landwehr Janna , Kolip Petra 
Published: June 2020

Zusammenfassung
Hintergrund
Die Förderung des aktiven Transports, insbesondere im Nahbereich, gilt als wichtiger Schlüssel zur Reduktion kindlichen Übergewichts. Für eine effektive Bewegungsförderung gilt die partizipative Interventionsentwicklung als wichtiges Qualitätsmerkmal. Bislang werden Kinder aber selten einbezogen.

Ziel der Arbeit
Ziel der Studie ist es, die Bedürfnisse von Grundschulkindern in Bezug auf die Nahmobilität zu erfassen.

Material und Methoden
Zur Erfassung der kindlichen Perspektive wurde die Methode Photovoice genutzt: 18 Kinder einer 3. Schulklasse (9 weiblich, 9 männlich) machten mit einer Kamera 5 Fotos zur eigenen Nahmobilität. In anschließenden Gruppeninterviews à 4–5 Kinder dienten die Fotos als Gesprächsanreiz. Die Interviews wurden transkribiert und inhaltsanalytisch ausgewertet.

Ergebnisse
Die befragten Kinder befürworten es, Wege aktiv zurückzulegen. Die Erreichbarkeit von z. B. Läden, Spielplätzen und Freunden ist ihnen wichtig. Sie wird aber von Hindernissen und Umwegen erschwert. Auch der Aspekt der Sicherheit wird von ihnen betont. Regelverstöße von Erwachsenen (Überfahren roter Ampeln, Geschwindigkeitsüberschreitungen) werden als gefährlich wahrgenommen. Die befragten Kinder formulieren kreative Ideen für Infrastrukturmaßnahmen, einschließlich des Ausbaus von Fahrradwegen. Mit diesen könnte aus ihrer Sicht das Fahrrad als Fortbewegungsmittel auch für Erwachsene attraktiver werden.

Diskussion
Die Studie belegt das große Bedürfnis von Grundschulkindern an eigenständiger Mobilität. Die Gewährleistung ihrer Sicherheit ist ihnen ein großes Anliegen. Der Systemvorteil des Fahrrades in der Nahmobilität kann aus ihrer Sicht durch Infrastrukturmaßnahmen deutlich gestärkt werden.
A complementary analysis of the porous structure of biochars obtained from biomass
Authors: Kwiatkowski Mirosław , Kalderis Dimitrios 
Published: June 2020

Abstract
This paper presents the results of the analysis of the porous structure of biochars produced from biomass, namely eucalyptus, wood chips, pruning waste and rice husk. The structural analysis was carried out using the BET, the t-plot, the NLDFT and the LBET methods, which yielded not only complementary information on the adsorptive properties of obtained biochars from these materials, but also information on the usefulness of the structural analysis methods in question for the research into an effect of the technology of carbonaceous adsorbent preparation.