bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central giant cell granuloma mimicking a periapical lesion of endodontic origin: A case report
Authors: Candeiro George Táccio de Miranda , de Souza Cláudia Vanuzia Torres , Chaves Renata Suelen Amorim , Ley Amanda Mourão , Feijão Camila Pontes , Costa Fábio Wildson Gurgel , Barros Silva Paulo Goberlânio 
Published: August 2020

AbstractThis paper aims to report a case in which central giant cell granuloma (CGCG) mimicked a periapical lesion of endodontic origin. An 18‐year‐old female patient was referred for diagnosis and treatment of extensive radiolucent periapical lesion involving 31, 32, 33, 34 and 35 teeth. Clinically, the patient presented slight facial asymmetry and healthy teeth on the affected side with positive response to thermal vitality tests. Thus, an incisional biopsy was performed, which presented a histopathological picture characteristic of a CGCG. The endodontic treatment of the involved teeth was followed by surgical curettage of the lesion. After two years of follow‐up, the patient was asymptomatic, with marked improvement in mandibular symmetry and adequate healing of the lesion. Therefore, the diagnosis of radiolucent periapical lesions must include lesions of endodontic and non‐endodontic origin for better treatment planning and execution.
Caesarean scar ectopic pregnancy: Evolution from medical to surgical management
Authors: Roche Caitlin , McDonnell Rose , Tucker Paige , Jones Kym , Milward Kristy , McElhinney Bernadette , Mehrotra Chhaya , Maouris Panayiotis 
Published: August 2020

BackgroundCaesarean scar ectopic pregnancy (CSP) is defined as blastocyst implantation occurring in a uterine scar. The incidence of CSP continues to rise with increasing caesarean section rates; prevalence is estimated to be 1:1800 to 1:2226 of all pregnancies. To date, over 30 treatment regimens have been published. The Royal College of Obstetricians and Gynaecologists guidelines (2016) state there is insufficient evidence to support one specific intervention over another.AimTo review outcomes of medical and surgical management of CSP cases at a single tertiary centre over a nine‐year period, in order to establish the safest and most effective management approach.Materials and MethodsAn audit was undertaken of patients treated for CSP between January 2009 and March 2017 at King Edward Memorial Hospital, Western Australia. Patient demographic and treatment outcome data were extracted from medical records.ResultsFifty‐one patients were identified as having CSP diagnosed during this time period, of which five were excluded due to lack of data, leaving a total of 46 cases. The majority of patients (52%, n = 24) elected for initial surgical management, while 41% (n = 19) trialled medical management. Seven percent (n = 3) opted for conservative management. Success rates of surgical, medical and conservative management were 100%, 53% and 0% respectively (P < 0.001). Medical management was associated with prolonged follow‐up; there was no difference in complication rates between surgical and medical managements.ConclusionsIn this audit, surgical management was the most effective way to manage CSP. There was no significant difference in complication rates between the two groups.
Molecular assessment of antibody‐mediated rejection in human pancreas allograft biopsies
Authors: Roufosse Candice , Drachenberg Cinthia , Renaudin Karine , Willicombe Michelle , Toulza Frederic , Dominy Kathy , McLean Adam , Simmonds Naomi , de Kort Hanneke , Cantarovitch Diego , Scalea Joseph , Mengel Michael , Adam Benjamin 
Published: August 2020

AbstractPancreas transplant longevity is limited by immune rejection, which is diagnosed by graft biopsy using the Banff Classification. The histological criteria for antibody‐mediated rejection (AMR) are poorly reproducible and inconsistently associated with outcome. We hypothesized that a 34‐gene set associated with antibody‐mediated rejection in other solid organ transplants could improve diagnosis in pancreas grafts. The AMR 34‐gene set, comprising endothelial, natural killer cell and inflammatory genes, was quantified using the NanoString platform in 52 formalin‐fixed, paraffin‐embedded pancreas transplant biopsies from 41 patients: 15 with pure AMR or mixed rejection, 22 with T cell‐mediated rejection/borderline and 15 without rejection. The AMR 34‐gene set was significantly increased in pure AMR and mixed rejection (P = .001) vs no rejection. The gene set predicted histological AMR with an area under the receiver operating characteristic curve (ROC AUC) of 0.714 (P = .004). The AMR 34‐gene set was the only biopsy feature significantly predictive of allograft failure in univariate analysis (P = .048). Adding gene expression to DSA and histology increased ROC AUC for the prediction of failure from 0.736 to 0.770, but this difference did not meet statistical significance. In conclusion, assessment of transcripts has the potential to improve diagnosis and outcome prediction in pancreas graft biopsies.
Teledermatologie in den Zeiten von COVID‐19 – ein systematisches Review
Authors: Elsner Peter 
Published: August 2020

ZusammenfassungDie COVID‐19‐Pandemie schränkt die Versorgung dermatologischer Patienten vielfach ein. Teledermatologische Leistungen wie die Videokonsultation oder die „Store‐and‐Forward“‐Teledermatologie könnten dies zumindest teilweise kompensieren. Diese systematische Übersicht fasst alle publizierten Studien zur Teledermatologie unter den Bedingungen der COVID‐19‐Pandemie zusammen. Sie stützt sich auf eine MEDLINE‐Recherche nach Artikeln aus dem Jahr 2020 in englischer und deutscher Sprache.Zwei Umfragen unter Dermatologen aus den USA und Indien ergaben, dass mehr als 80 % teledermatologische Versorgung anboten. Unter deutschen Dermatologen boten von 480 Antwortenden 17,5 % eine Online‐Video‐Konsultation, 11,3 % eine Offline‐Beratung (Store and Forward) und 10,0 % beide Verfahren an. Fünf Kohortenstudien zur Teledermatologie während der Pandemie wurden identifiziert. Drei davon untersuchten teledermatologische Verfahren bei chronischen Dermatosen (Akne, entzündliche Hauterkrankungen), eine beschäftigte sich mit der Betreuung onkologischer Patienten mit dermatologischen Komplikationen, und eine analysierte Telekonsile bei COVID‐19‐Verdachtsfällen. In allen Studien konnten durch die Teledermatologie persönliche Konsultationen weitgehend reduziert werden.Die Ergebnisse sprechen dafür, dass die Einschränkungen persönlicher dermatologischer Betreuung von Patienten mit Hautkrankheiten während der COVID‐19‐Pandemie durch eine Erweiterung teledermatologischer Leistungen zumindest teilweise kompensiert werden kann. Erkenntnisse aus der Nutzung der Teledermatologie während der Pandemie sollten für eine weitere Verbesserung des Einsatzes und der Akzeptanz der Teledermatologie bei Patienten und Dermatologen genutzt werden.
Milben, Raupen und Falter
Authors: Panzer Rüdiger , Krebs Susanne 
Published: August 2020

ZusammenfassungAbgesehen von der Skabies und der Hausstaubmilbenallergie stehen Erkrankungen durch Milben oder Raupen seltener im Mittelpunkt. Gleichwohl können Milben und Raupen auf vielfältige Weise medizinisch relevant werden. Milben können hierbei als Parasiten auftreten, die die Haut besiedeln wie bei Skabies, zoonotischen Skabies‐ähnlichen Erkrankungen oder Demodikose oder die Gewebsflüssigkeit oder Blut saugen wie bei der Trombidiose. In letzterem Fall spielen sie zudem als Vektoren eine Rolle und können unter anderemOrientia tsutsugamushi, den Erreger des Tsutsugamushi‐Fiebers übertragen. Allergenes Potenzial haben neben Hausstaubmilben auch Vorratsmilben.Für sehr unterschiedliche Erkrankungen, die durch Raupen oder Falter ausgelöst werden, sind die Begriffe Erukismus und Lepidopterismus in Gebrauch. Beide Begriffe werden nicht einheitlich verwendet. Bezüglich der Pathogenese wurden Typ‐I‐Allergien, Typ‐IV‐Allergien, irritative und toxinvermittelte Reaktionen beschrieben. In Deutschland sind hierbei Hautreaktionen nach Kontakt mit den Härchen der Raupen des Eichenprozessionsspinners am häufigsten. Extrakutane Reaktionen mit Übelkeit, Erbrechen, Blutungen, Arthropathien oder sogar lebensgefährliche Reaktionen sind bei verschiedenen exotischen Arten bekannt. Einige Spezies haben sich auf Parasitismus durch Blutsaugen oder Aufnahme von Tränenflüssigkeit spezialisiert.Naturseide kann allergische Soforttyp‐ und Spättypreaktionen hervorrufen. Arbeiter in der Seidenherstellung können allergisches Asthma, allergische Rhinitis oder allergische Konjunktivitis entwickeln. Der Verzehr von Puppen der Seidenspinner birgt das Risiko von Nahrungsmittelallergien.
Continuous epileptiform discharges during sleep as an evolutionary pattern in patients with congenital Zika virus syndrome
Authors: van der Linden Hélio , van der Linden Vanessa , Pessoa André , D. Valente Kette 
Published: August 2020

AbstractCongenital Zika virus syndrome (CZVS) is associated with severe neurological deficits. Clinical characteristics of epilepsy and the electroencephalographic (EEG) pattern in CZVS were documented in infancy. In this study, we aimed to describe the EEG findings observed during the follow‐up of children with CZVS. Seventy‐six EEGs of 55 children (60% female; mean age = 50 months) with confirmed CZVS were analyzed, considering the background, interictal, and ictal epileptiform discharges. Continuous (or almost continuous) epileptiform discharges during non–rapid eye movement sleep were identified in 22 (40%) patients. In 20 (90.1%) patients, the pattern was symmetrical, with an anterior predominance of the epileptiform activity. All patients with this pattern had epilepsy, which was severe in 15 (68.2%) and demanded polytherapy in 19 (86.4%). Subcortical calcifications (77.3%) and multifocal EEGs (72.8%) in earlier ages occurred more often in patients with this pattern. Other unspecific interictal EEG patterns were focal epileptiform discharges in 23 (41.8%) and multifocal activity in six (10.9%). In CZVS, continuous (or almost continuous) epileptiform discharges during sleep emerge as a pattern after the second year of life. This was associated with severe and drug‐resistant epilepsy, but not necessarily with an apparent regression. Subcortical calcifications and multifocal epileptiform discharges in infancy are associated with this pattern.
Adapting to climate‐driven distribution shifts using model‐based indices and age composition from multiple surveys in the walleye pollock (Gadus chalcogrammus) stock assessment
Authors: O’Leary Cecilia A. , Thorson James T. , Ianelli James N. , Kotwicki Stan 
Published: August 2020

AbstractThe northern Bering Sea is transitioning from an Arctic to subarctic fish community as climate warms. Scientists and managers aim to understand how these changing conditions are influencing fish biomass and spatial distribution in this region, as both are used to inform stock assessments and fisheries management advice. Here, we use a spatio‐temporal model for walleye pollock (Gadus chalcogrammus) to provide two inputs to its stock assessment model: (a) an alternative model‐based biomass index and (b) alternative model‐based age compositions. Both inputs were derived from multiple fishery‐independent data that span different regions of space and time. We developed an assessment model that utilizes both the standard and model‐based inputs from multiple surveys despite inconsistencies in spatial and temporal coverage, and we found that using these data provide an improved spatial and temporal scope of total pollock biomass. Age composition information indicated that pollock density is increasing and moving farther north, particularly for older pollock. We found that including an index of cold pool extent could be used to extrapolate pollock densities in the northern Bering Sea in unsampled years. Stock assessment parameter estimates were similar for standard and model‐based input. This study demonstrates that spatio‐temporal model‐based estimates of a biomass index and age composition can facilitate rapid changes in stock assessment structure in response to climate‐driven shifts in spatial distribution. We conclude that assimilating data from regions neighboring standard survey areas, such as the Chukchi Sea and western Bering Sea, would improve understanding and management efforts as fish distributions change under a warming climate.
Comparison of embolic effect between water‐in‐oil emulsion and microspheres in transarterial embolization for rat hepatocellular carcinoma model
Authors: Minamiguchi Kiyoyuki , Tanaka Toshihiro , Nishiofuku Hideyuki , Fukuoka Yasushi , Taiji Ryosuke , Matsumoto Takeshi , Saito Natsuhiko , Taguchi Hidehiko , Marugami Nagaaki , Hirai Toshiko , Kichikawa Kimihiko 
Published: August 2020

AimTo compare two different embolic materials, water‐in‐oil (W/O) emulsion followed by gelatin particles and microspheres in transarterial embolization (TAE), using a rat hepatocellular carcinoma model.MethodsTwenty rats bearing N1S1 cells were divided into the W/O emulsion group and Microsphere group. Water‐in‐oil emulsion was created by a glass membrane emulsification device. The tumor vascularity was measured by contrast‐enhanced ultrasonography 24 h before and 10 min and 48 h after TAE. Tumor necrosis, hepatic infarction ratio surrounding the tumor, and locations of the embolic materials 48 h after TAE were assessed. The changes of serum liver enzymes were also evaluated. Statistical significance was determined by using either the Mann–Whitney U‐test or Fisher's exact test.ResultsThe tumor vascularity 48 h after TAE was significantly higher in the Microsphere group (20.1 vs. 3.76%, P = 0.016). The overflow of Lipiodol into the portal veins surrounding the tumor was seen, whereas microspheres were seen only in the artery. The percentage of necrotic area and complete response ratio in the W/O emulsion group was significantly higher (99.9 vs. 87.6%, P = 0.029 and 87.5 vs. 28.6%, P = 0.041, respectively). Serum aspartate aminotransferase and serum alanine aminotransferase levels 48 h after TAE were significantly higher in the W/O emulsion group (P < 0.01).ConclusionsThe embolization using W/O emulsion followed by gelatin particles showed stronger antitumor effects with the occlusion of both the tumor feeding artery and the portal vein compared with microspheres, which occluded only the arteries.
Pricing strategies for O2O business model considering service spillover and power structures
Authors: Chai Limeng , Duan Yongrui , Huo Jiazhen 
Published: August 2020

AbstractIn contradistinction to the traditional dual‐channel retail model, the online and offline channels are two business units of a single retailer in an online to offline (O2O) business model. The service‐related effort of the offline channel has a spillover effect on the online channel. This paper establishes three game‐theoretic models to analyze how service spillover and power structures affect supply chain members’ performance in the O2O business model. The main results are as follows. First, a service spillover effect is always beneficial to the manufacturer's profit due to the increasing wholesale price and total demand in all three scenarios. Second, unlike the traditional dual‐channel model, service spillover does not inevitably cause price competition in the O2O dual‐channel model. Under different power structure conditions, the spillover intensity has a significant effect on the retailer's profit and service strategy. When the manufacturer is a Stackelberg leader, the effects of spillover on a retailer's profit depend on online channel acceptance level and service level. A service differentiation strategy can help the retailer increase profit margins under certain situations. When the manufacturer and retailer have the same power, retailer's profit increases with spillover intensity, and a service consistency strategy can be implemented. When the retailer is a Stackelberg leader, the retailer's profit decreases first and then increases, and a service mixed strategy will reduce the loss of retailer's profit. Finally, the switch in dominant power between manufacturer and retailer has no impact on retail prices and demand. The total supply chain profit in two Stackelberg models is also equivalent, but lower than that in the Nash model.
Development of a prognostic gene signature based on an immunogenomic infiltration analysis of osteosarcoma
Authors: Yu Yiyang , Zhang Hongliang , Ren Tingting , Huang Yi , Liang Xin , Wang Wei , Niu Jianfang , Han Yu , Guo Wei 
Published: August 2020

AbstractOsteosarcoma is the most common primary malignant bone tumour predominantly occurring in children and adolescents with a high tendency of local invasion and early metastases. Currently, tumour immune microenvironment (TME) is becoming the focus of studying of malignant tumours.. However, no sound evidence shows a specific immune molecular target in osteosarcoma. We downloaded the gene expression profile and clinical data of osteosarcoma from the TARGET portal, and extracted and normalized via R software. Then, the immune cell infiltration assessed by CIBERSORT and ESTIMATE algorithms. Three survival‐related immune cells and immune score were obtained via Kaplan‐Meier survival analysis, and 232 immune‐related genes were obtained as candidate genes. Enrichment and protein‐protein interaction co‐expression analyses were performed to identify 13 hub genes. Lastly, a seven gene prognostic signature was identified by univariate and multivariate Cox regression analyses. More importantly, our validations and TIMER algorithm suggested this immune‐related prognostic signature a good predictive tool. Our findings have provided novel insights that could demonstrate new targets of immunotherapy in osteosarcoma.
Nursing facility residents’ cardiopulmonary resuscitation decisions
Authors: Myers Anne L. , Matthias Marianne S. 
Published: August 2020

AbstractContextAs many as one‐quarter of all residents in nursing facilities have cardiopulmonary resuscitation (CPR) as a documented choice in the medical record, despite the likelihood of limited medical benefit in this setting.ObjectivesThe aim of this study was to understand the perspectives of healthcare providers and nursing facility residents regarding CPR decisions.MethodsWe used qualitative interviews to examine the perspectives of residents with a documented decision for CPR in the medical record. We then compared residents’ views with those of healthcare providers who routinely conduct advance care planning (ACP) conversations in the nursing facility setting.ResultsFive themes emerged from the interviews: (a) Resident versus Provider Concerns, (b) Offering Information versus Avoidance, (c) Lack of Understanding of CPR, (d) Lack of Awareness, and (e) ‘Don't Keep Me on Machines'. Residents held misconceptions about CPR and/or exhibited an overall poor understanding of the relationship between their own health status and the likelihood of a successful CPR attempt. Although healthcare providers offer information and health education in an attempt to address knowledge gaps, these efforts are not always successful or even accepted by residents. Resident viewpoints and priorities differed from healthcare providers in ways that affected communication about CPR.ConclusionsUnrecognised differences in perceptions between providers and residents affect key aspects of ACP communication that can impact CPR decision‐making. The concerns and priorities of institutionalized older adults may differ from those of healthcare providers, creating challenges for engaging some residents in ACP.Implications for PracticeACP communication models and training should be designed not only to explore nursing facility residents' goals, values, and preferences, but also to elicit any underlying differences in perceptions that may affect communication. Healthcare providers can identifying the primary concerns of residents and assist them with integrating or reframing these issues as a part of ACP discussions.
Grating Visual Acuity in phakic, aphakic, and pseudophakic Poodles
Authors: Safatle Angélica M. V. , de Moraes Tatiana A. , Eyherabide Ana R. , Fernandes Arthur G. , Jorge Juliana S. , Carvalho Laysa M. C. R. , Rodriguez Emily A. K. , Otsuki Denise , Bolzan Aline A. , Sacai Paula Y. 
Published: August 2020

AbstractObjectiveTo compare the grating visual acuity (VA) measured by visual evoked potentials (VEP) in phakic, aphakic, and pseudophakic Poodles.Animals studiedThirty‐six Poodle dogs aged from 4 to 14 years.ProceduresAnimals were allocated into three different groups according to their lens status: phakic group (n = 12), aphakic group (n = 12), and pseudophakic group (n = 12). Grating VA was measured in cycles/degree (cpd) in all animals using the electrodiagnosis system Roland RETIport®in a dark room without using any mydriatic, sedative, or anesthetic drugs.ResultsThe mean grating VA in the phakic, aphakic, and pseudophakic groups was 5.9 ± 1.0 cpd (20/102—Snellen equivalent), 2.6 ± 0.7 cpd (20/231), and 5.2 ± 1.1 cpd (20/116), respectively. The VA from aphakic eyes was significantly lower when compared to the phakic and pseudophakic eyes (P < .05). There was no significant difference in VA between phakic and pseudophakic eyes.ConclusionsThe VEP is a useful tool for the evaluation of grating visual acuity in canines. The study showed that IOL implantation following phacoemulsification results in improved VA as measured by VEP compared to that of the aphakic eye and resulted in VA that was similar to that of the normal eye.
Social determinants of deaths from pneumonia and tuberculosis in children in Brazil: an ecological study
Authors: Berra Thaís Zamboni , Assis Ivaneliza Simionato de , Arroyo Luiz Henrique , Arcoverde Marcos Augusto Moraes , Alves Josilene Dália , Campoy Laura Terenciani , Alves Luana Seles , Crispim Juliane de Almeida , Bruce Alexandre Tadashi Inomata , Alves Yan Mathias , Lima dos Santos Felipe , da Costa Uchôa Severina Alice , Fiorati Regina Celia , Lapão Luis , Arcêncio Ricardo Alexandre 
Published: August 2020

ObjectiveTo identify the risk areas of deaths due to unspecified pneumonia and tuberculosis (TB) in children, and to identify if there is a relationship between these events with higher TB incidence and social determinants.MethodsEcological study carried out in Brazil. All cases of TB or unspecified pneumonia deaths in children under 5 years of age reported between 2006 and 2016 were included and collected through Department of Informatics of the Unified Health System (Brazil’s electronic database). The Spatial Scan Statistics was used to identify areas at higher risk of dying from this event. The spatial association was verified through the Getis-Ord techniques. The Bivariate Moran Global Index was used to verify the spatial autocorrelation between the two events. To identify the association of TB and pneumonia deaths with endemic areas of pulmonary TB and social determinants, four explanatory statistical models were identified.ResultsA total of 21 391 cases of pneumonia and 238 cases of TB were identified. Spatial scanning analysis enabled the detection of four clusters of risk for TB (relative risk, RR, between 3.30 and 18.18) and 22 clusters for pneumonia (RR between 1.38 and 5.24). The spatial association of the events was confirmed (z-score 3.74 and 64.34) and spatial autocorrelation between events (Moran Index:0.031 (p=0.001)). The zero-inflated negative binomial distribution was chosen, and an association for both events was identified with the TB incidence rate (OR 5.3, 95% CI 2.85 to 9.84; OR 6.63, 95% CI 5.62 to 7.81), with the Gini Index (OR 1.78, 95% CI 1.12 to 2.82; OR 4.22, 95% CI 3.63 to4.92). Primary care coverage showed an inverse association for both events (OR 0.10, 95% CI 0.67 to 0.17; OR 0.18, 95% CI 0.15 to 0.21) for pneumonia). Finally, a family that benefited from the Bolsa Família Programme had an inverse association for deaths from pneumonia (OR 0.81, 95% CI 0.52 to 1.25).ConclusionsThe results do not just contribute to reduce mortality in children, but mainly contribute to prevent premature deaths through identification of critical areas in Brazil, which is crucial to qualify health surveillance services.