bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional [18F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer’s disease
Authors: Wolters Emma E. , Ossenkoppele Rik , Verfaillie Sander C. J. , Coomans Emma M. , Timmers Tessa , Visser Denise , Tuncel Hayel , Golla Sandeep S. V. , Windhorst Albert D. , Boellaard Ronald , van der Flier Wiesje M. , Teunissen Charlotte E. , Scheltens Philip , van Berckel Bart N. M. 
Published: April 2020

Abstract
Purpose
In vivo Alzheimer’s disease (AD) biomarkers for tau pathology are cerebrospinal fluid (CSF) phosphorylated tau (p-tau) and [18F]flortaucipir positron emission tomography (PET). Our aim was to assess associations between CSF p-tau with [18F]flortaucipir PET and the associations of both tau biomarkers with cognition and atrophy.

Methods
We included 78 amyloid positive cognitively impaired patients (clinical diagnoses mild cognitive impairment (MCI, n = 8) and AD dementia (n = 45) and 25 cognitively normal subjects with subjective cognitive decline (SCD) (40% amyloid-positive)). Dynamic 130 min [18F]flortaucipir PET scans were acquired to generate binding potential (BPND) images using receptor parametric mapping and standardized uptake values ratios of 80–100 min (SUVr80-100min) post injection. We obtained regional BPND and SUVr from entorhinal, limbic, and neocortical regions-of-interest (ROIs), closely aligning to the neuropathological tau staging schemes. Cognition was assessed using MMSE and composite scores of four cognitive domains, and atrophy was measured using gray matter volume covering the major brain lobes. First, we used linear regressions to investigate associations between CSF p-tau (independent variable) and tau PET (dependent variable). Second, we used linear regressions to investigate associations between CSF p-tau, tau PET (separate independent variables, model 1), and cognition (dependent variable). We then assessed the independent effects of CSF p-tau and tau PET on cognition by simultaneously adding the other tau biomarker as a predictor (model 2). Finally, we performed the same procedure for model 1 and 2, but replaced cognition with atrophy. Models were adjusted for age, sex, time lag between assessments, education (cognition only), and total intracranial volume (atrophy only).

Results
Higher [18F]flortaucipir BPND was associated with higher CSF p-tau (range of standardized betas (sβ) across ROIs, 0.43–0.46; all p < 0.01). [18F]flortaucipir BPND was more strongly associated with cognition and atrophy than CSF p-tau. When [18F]flortaucipir BPND and CSF p-tau were entered simultaneously, [18F]flortaucipir BPND (range sβ = − 0.20 to – 0.57, all p < 0.05) was strongly associated with multiple cognitive domains and atrophy regions. SUVr showed comparable results to BPND.

Conclusion
Regional [18F]flortaucipir BPND correlated stronger with cognition and neurodegeneration than CSF p-tau, suggesting that tau PET more accurately reflects disease severity in AD.
A team of pursuit learning automata for solving deterministic optimization problems
Authors: Yazidi Anis , Bouhmala Nourredine , Goodwin Morten 
Published: April 2020

AbstractLearning Automata (LA) is a popular decision-making mechanism to “determine the optimal action out of a set of allowable actions” [1]. The distinguishing characteristic of automata-based learning is that the search for an optimal parameter (or decision) is conducted in the space of probability distributions defined over the parameter space, rather than in the parameter space itself [2]. In this paper, we propose a novel LA paradigm that can solve a large class of deterministic optimization problems. Although many LA algorithms have been devised in the literature, those LA schemes are not able to solve deterministic optimization problems as they suppose that the environment is stochastic. In this paper, our proposed scheme can be seen as the counterpart of the family of pursuit LA developed for stochastic environments [3]. While classical pursuit LAs can pursue the action with the highest reward estimate, our pursuit LA rather pursues the collection of actions that yield the highest performance by invoking a team of LA. The theoretical analysis of the pursuit scheme does not follow classical LA proofs, and can pave the way towards more schemes where LA can be applied to solve deterministic optimization problems. Furthermore, we analyze the scheme under both a constant learning parameter and a time-decaying learning parameter. We provide some experimental results that show how our Pursuit-LA scheme can be used to solve the Maximum Satisfiability (Max-SAT) problem. To avoid premature convergence and better explore the search space, we enhance our scheme with the concept of artificial barriers recently introduced in [4]. Interestingly, although our scheme is simple by design, we observe that it performs well compared to sophisticated state-of-the-art approaches.
Optimal professional development ICT training initiatives at flagship universities
Authors: Wang Xi , Jacob W. James , Blakesley Christopher C. , Xiong Weiyan , Ye Huiyuan , Xu Shangmou , Lu Fang 
Published: April 2020

AbstractThis study explores best practices and roles of information and communication technology (ICT) in select professional development centers at 16 flagship universities. Through adopting a qualitative case study design, this study explores the strengths and weaknesses of current technology training initiatives in the selected professional development centers. As part of the research and teaching programs at flagship universities, professional development center leaders shared about the current ICT practices as well as the strengths and limitations of their own centers. The analysis section includes a critical look at ICT practices among flagship universities from a human resource theory lens. Findings indicate common successes that facilitate the ICT practices of these centers including delivery mediums, services, ideas, and goals, as well as various barriers of implementing ICT training initiatives. The paper concludes with suggestions on how professional development center leaders, senior administrators, and educational policy makers can help improve professional development processes with the assistance of optimal ICT initiatives.
Mere presence of informal guardians deters burglars: a virtual reality study
Authors: van Sintemaartensdijk Iris , van Gelder Jean-Louis , van Prooijen Jan-Willem , Nee Claire , Otte Marco , van Lange Paul 
Published: April 2020

Abstract
Objectives
This study investigates the deterrent effects of incremental levels of guardianship on residential burglary and assesses how burglars differ from non-burglars in terms of their perceptions of opportunities for burglary.

Methods
In a virtual reality experiment, 181 incarcerated burglars and 172 non-burglars (university students) were tasked to appraise a virtual neighbourhood in search of a burglary target. During the appraisal process, participants were exposed to different levels of guardianship, ranging from the mere presence of a guardian to an intervening guardian.

Results
The presence of a guardian deterred both burglars and non-burglars alike, with only negligible incremental effects for levels of guardianship. For burglars, guardianship increased the perceived likelihood of being caught and the perceived level of social cohesion, whereas it decreased neighbourhood attractiveness. The burglars differed from the non-burglars in terms of how they appraised the virtual neighbourhood, clearly reflecting differences in expertise between both groups.

Conclusions
With respect to residential burglary, the results suggest that guardians—in line with the original notion of guardianship developed by Cohen and Felson (American Sociological Review, 44(4), 588–608, 1979)—serve as a deterrent simply by being present.
Bubble Evolution on Different Carbon Anode Designs in Cryolite Melt
Authors: Stanic Nikolina , Jevremovic Ivana , Martinez Ana Maria , Sandnes Espen 
Published: April 2020

Abstract
The anode potential has been shown to be highly dependent on anode geometry and orientation in the Hall–Héroult process. This work is an experimental laboratory scale study of the effect of anode geometry and orientation on bubble formation and detachment for four different anode designs: horizontal (surface facing downwards), inverted horizontal (surface facing upwards), vertical, rod (with both vertical and horizontal surface). From polarization curves, it was found that the vertical anode and the inverted horizontal anode operated at lowest potentials. Above 1 A cm−2, the vertical anode showed the lowest potential. As the current increases, the transition towards smaller noise is pronounced for the horizontal anode and to some degree for the vertical anode and inverted horizontal anode. Fast Fourier Transform analysis of chronoamperometric data gave a dominant frequency only for the horizontal anode and the rod anode. The bubble release time corresponded well with the dominant frequency for the rod anode for all current densities and for the horizontal anode at lower current densities. Only random bubble noise was found for the vertical and the inverted horizontal anode and is probably due to a bubble-induced convection effectively removing the bubbles.
Latent profile analysis of students’ reading development and the relation of cognitive variables to reading profiles
Authors: Holopainen Leena , Hoang Nhi , Koch Arno , Kofler Doris 
Published: April 2020

AbstractPrevious studies have showed that early problems with word decoding can lead to poor performance in text reading and comprehension and suggest that poor readers often struggle with reading deficits throughout their school years. Therefore, early detection of those children who are at risk for slow reading development and/or who belong to the lowest reading profiles is essential in order to organize proper support. The present study explores the heterogeneity and prevalence of latent reading profiles among 769 Finnish- and German-reading students during their first and second school years in three countries (Finland, Germany, and Italy) using latent profile analysis. The results identified three latent profiles among Finnish readers, one of which (sentence-level reading) was identified as developing slowly. Among German-reading students, four latent profiles were discovered, two of which were identified as developing slowly. The results of ordinal logistic regression modeling show that rapid automatic naming (RAN) was significantly related to poorer reading profiles among Finnish- and German-reading students, and that the poorer results in letter-sound connection testing among the German-reading group was also significantly related to poorer reading profiles. Although the educational systems have some differences between Germany and German-speaking areas of Italy, no significant country effect was detected. In addition, a child’s age and spoken language did not significantly affect the student’s reading profile.
Changes in food access by mestizo communities associated with deforestation and agrobiodiversity loss in Ucayali, Peruvian Amazon
Authors: Blundo-Canto Genowefa , Cruz-Garcia Gisella S. , Talsma Elise F. , Francesconi Wendy , Labarta Ricardo , Sanchez-Choy Jose , Perez-Marulanda Lisset , Paz-Garcia Paula , Quintero Marcela 
Published: April 2020

AbstractFew longitudinal studies link agricultural biodiversity, land use and food access in rural landscapes. In this paper, we test the hypothesis that, in a context of economic change, cash crop expansion is associated with deforestation, reduced agrobiodiversity and changes in food access. For this purpose, we analysed data collected from the same 53 upland and floodplainmestizohouseholds in Ucayali, Peru, in 2000 and 2015. We found an emerging transition towards less diversified food access coupled with loss of forest cover and reduced agricultural biodiversity. In 2015, diets appeared to rely on fewer food groups, fewer food items, and on products increasingly purchased in the market compared to 2000. Wild fruits and plants were mentioned, but rarely consumed. Agricultural production systems became more specialised with a shift towards commercial crops. Peak deforestation years in the 15-year period appeared linked with incentives for agricultural expansion. Our results suggest an overall trend from diversified productive and “extractive” systems and more diverse food access, towards specialized productive systems, with less diverse food access and stronger market orientation (both in production and consumption). The assumption in the food and agricultural sciences that increased income and market-orientation is linked to improved food security, is challenged by our integrated analyses of food access, agrobiodiversity, land use and forest cover. Our results highlight the importance of longitudinal, multidimensional, systemic analyses, with major implications for land use, food and health policies. The potential risks of parallel homogenisation of diets and agricultural production systems require interdisciplinary research and policies that promote integrated landscape approaches for sustainable and inclusive food systems.
Characteristics of Precipitation Particles Measured by PARSIVEL Disdrometer at a Mountain and a Coastal Site in Korea
Authors: Cha Joo Wan , Yum Seong Soo 
Published: April 2020

AbstractThis study analyzed HC (Hydrometeor Classification), rain rate, and DSD (Drop Size Distribution) observed using an optical disdrometer, parsivel, at a mountain (Daegwallyeong, DG) and a coastal site (Mokpo, MP) over 2 years (2010–2011). The HC accuracies of the drizzle, rain, and snow were about 95%, 87%, and 80% respectively. The R2 (coefficient of determination) of the parsivel with TB (Tipping Bucket) rain gauge was 0.91 at MP and 0.96 at DG. The shapes of drizzle and rain DSD observed at DG and MP were similar while the variation in snow DSD was easily influenced by weather condition such as temperature and wind speed. The relatively warm temperature (–5 °C ∼ -0 °C) increased the snow particle number concentration at around 0.6~1 mm diameter and the relatively cold temperature (–15 °C ∼ -10 °C) decreased it above 2 mm diameter. Although wind speed was not a strong factor in snow DSD, larger particles were apt to form in relatively strong wind conditions. Due to different wind directions for the maritime and continental regions, snow particle number density (N(D)) at MP and DG exhibited large differences in terms of snow DSD shape and the number concentration. For instance, in the maritime precipitation, snow DSD shape at MP was broader than that at DG and small-size snow particles were observed at DG more frequently than at MP. In addition, camera-observed snow particle type measurement was carried out at DG in January to March 2010. During the measurement at DG, a mixed type of plate and column was the most frequent and an aggregation of plate type frequently occurred at lower temperatures.
Minority Stress, Campaign Messages and Political Participation during the Australian Marriage Plebiscite
Authors: Bartos Sebastian E. , Noon Daniel W. , Frost David M. 
Published: April 2020

Abstract
Background
The health and wellbeing of sexual minorities is adversely impacted by a set of factors collectively known as minority stress. Recently, negative campaigns preceding gay-rights referenda have put further pressure on sexual minorities. However, active participation in political campaigns is expected to foster wellbeing. This study explores the mechanisms through which political campaigns affect psychological distress in sexual minorities.

Method
We conducted a survey with 318 Australian sexual minority individuals during the campaign for the same-sex marriage postal vote in 2017.

Results
As expected, exposure to negative campaign messages was associated with psychological distress. This association persisted controlling for the effects of everyday stress. The effect of exposure to negative campaign messages was no longer significant when controlling for minority stressors like internalized homophobia, expectations of rejection, and everyday discrimination. Political participation was also associated with psychological distress. Post hoc analyses supported a model whereby minority stressors mediated the associations of campaign messages and political participation with distress.

Conclusion
Minority stress provides a flexible theoretical framework that can incorporate novel challenges to the wellbeing of sexual minorities.

Policy Implication
As public votes on the rights of sexual minorities become more common, it is important to develop models that can inform policy in protecting such minorities.
Chrysanthemum-like high-entropy diboride nanoflowers: A new class of high-entropy nanomaterials
Authors: Liu Da , Liu Honghua , Ning Shanshan , Chu Yanhui 
Published: April 2020

AbstractHigh-entropy nanomaterials have been arousing considerable interest in recent years due to their huge composition space, unique microstructure, and adjustable properties. Previous studies focused mainly on high-entropy nanoparticles, while other high-entropy nanomaterials were rarely reported. Herein, we reported a new class of high-entropy nanomaterials, namely (Ta0.2Nb0.2Ti0.2W0.2Mo0.2)B2high-entropy diboride (HEB-1) nanoflowers, for the first time. Formation possibility of HEB-1 was first theoretically analyzed from two aspects of lattice size difference and chemical reaction thermodynamics. We then successfully synthesized HEB-1 nanoflowers by a facile molten salt synthesis method at 1423 K. The as-synthesized HEB-1 nanoflowers showed an interesting chrysanthemum-like morphology assembled from numerous well-aligned nanorods with diameters of 20–30 nm and lengths of 100–200 nm. Meanwhile, these nanorods possessed a single-crystalline hexagonal structure of metal diborides and highly compositional uniformity from nanoscale to microscale. In addition, the formation of the as-synthesized HEB-1 nanoflowers could be well interpreted by a classical surface-controlled crystal growth theory. This work not only enriches the categories of high-entropy nanomaterials but also opens up a new research field on high-entropy diboride nanomaterials.
Is There an Association Between Schizophrenia and Sexual Dysfunction in Both Sexes? A Systematic Review and Meta-Analysis
Authors: Zhao Shankun , Wang Xiaolan , Qiang Xie , Wang Hui , He Jian , Shen Maolei , Zheng Changjun , Kang Ran 
Published: April 2020

Abstract

Background
Mounting clinical studies have reported patients with schizophrenia are at high risk of developing sexual dysfunction (SD), but a directly calculated prevalence of SD is currently lacking.

Aim
To further quantify the association between schizophrenia and SD.

Methods
MEDLINE (PubMed), Embase (OVID), the Cochrane Library databases, and the PsycINFO were systematically searched for eligible studies reporting the sexual functioning in patients with schizophrenia. This meta-analysis has been registered on PROSPERO (ID: CRD42019121720, http://www.crd.york.ac.uk/PROSPERO).

Outcomes
The relationship between schizophrenia and SD was detected by calculating the relative risk (RR) with a 95% confidence interval (CI). The GRADE-profiler was employed to rank the quality of the evidence.

Results
10 observational studies (3 case-control studies and 7 cross-sectional studies) were finally included, enrolling a total of 3,570 participants (mean age 28.6–46.2 years), of whom 1,161 had schizophrenia and the remainders were the healthy control subjects. Synthetic results indicated that schizophrenia was significantly associated with an increased risk of SD regardless of gender (3 studies reporting both sexes: RR = 2.24, 95%CI: 1.66–3.03, P &lt; .001, heterogeneity: I2 = 0.0%, P = .431; 7 studies reporting men: RR = 2.63, 95%CI: 1.68–4.13, P &lt; .001, heterogeneity: I2 = 82.7%, P &lt; .001; 5 studies reporting women: RR = 2.07, 95%CI: 1.46–2.94, P &lt; .001; heterogeneity: I2 = 79.7%, P = .001). In accordance with the GRADE-profiler, the quality of the evidence of primary outcomes was LOW, MODERATE, and LOW in studies including both sexes, men, and women, respectively.

Clinical Implications
Our findings confirmed the potential link between schizophrenia and SD. Clinicians should routinely assess the sexual functioning for those patients with schizophrenia and further recommend the preferred antipsychotics for them.

Strengths & Limitations
This is the first meta-analysis investigating the association between schizophrenia and the risks of SD in both sexes. Nonetheless, substantial heterogeneities were identified across the selected studies.

Conclusion
Robust data from this meta-analysis showed increased rates of SD in patients with schizophrenia compared with the general populations. Therefore, more specific psychological and pharmaceutical interventions are needed to help patients with schizophrenia gain a better sexual life.
La relation entre le judiciaire et les victimes dans le contexte de la détermination de la peine au Canada : un enjeu pour l’évolution du droit criminel
Authors: Labonté Sébastien 
Published: April 2020

RésuméL’objectif de cet article est de divulguer des résultats de recherches exploratoires sur le rapport entre le système judiciaire canadien et les victimes d’actes criminels dans le contexte de la détermination de la peine. De manière plus précise, l’auteur s’intéresse au processus de mise en forme des attentes des victimes qui opère à ce stade des procédures judiciaires. Pour observer ces mises en forme, l’auteur s’appuie sur des décisions judiciaires qui ont été rendues par les tribunaux canadiens. À partir de son corpus empirique, l’auteur décrit comment certaines attentes victimaires sont plus audibles que d’autres et comment leur intégration dans le processus de détermination de la peine varie en fonction du type d’attente et des circonstances à l’intérieur desquelles elles émergent.
Challenges and Responses: A Tertiary Hospital in 2019-nCoV Epidemic
Authors: Li Hong , Zhang Zhuo , Li Ping , Nie Hu 
Published: April 2020

ABSTRACTThe recent outbreak of coronavirus in Wuhan, China, has imposed challenges on the Chinese medical system. Not only the dramatically increasing number of infected cases and insufficient medical resources, but also the peoples’ panic throughout the whole country have made medical services extremely difficult. To respond to these challenges effectively, our hospital implemented an urgent response strategy, including human resources and medical resources preparation and re-allocation, immediate fever screening, strict patient-visiting flow management, and reasonable information communication. Our experience and response measures could provide a reference for other hospitals in the current situation.