bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbandingan Latihan Otot Isotonik dan Isometrik terhadap Peningkatan Kekuatan Otot Quadriceps Femoris pada Mahasiswa Program Studi Ilmu Keolahragaan Universitas Negeri Jakarta
Authors: Yanuarfiqri Aldira Madyansyah , Purba Ruliando Hasea , Dewanti Rina Ambar 
Published: December 2019

Abstrak.Tujuan penelitian ini adalah untuk mendapatkan hasil peningkatan kekuatan otot quadriceps femoris mahasiswa program studi Ilmu Keolahragaan Universitas Negeri Jakarta angkatan 2015, yaitu dengan menggunakan metode latihan isotonik dan metode latihan isometrik. Selain itu, juga mencari dan menemukan metode mana yang lebih signifikan dalam memberikan kontribusi pada hasil peningkatan kekuatan otot quadriceps femoris.
Penelitian ini merupakan penelitian kuantitatif dengan metode eksperimen. Jumlah populasi pada penelitian ini adalah seluruh Mahasiswa Program Studi Ilmu Keolahragaan Universitas Negeri Jakarta Angkatan 2015 dan sampel pada penelitian ini adalah Mahasiswa Program Studi Ilmu Keolahragaan Universitas Negeri Jakarta Angkatan 2015 yang diambil dengan metode purposive sampling. Data dikumpulkan dan diolah menggunakan metode uji T-Independen. Sampel dilibatkan dalam prosedur eksperimen pre-post two group design dengan 16 kali sesi latihan menggunakan Leg Extension Machine.
Hasil penelitian menunjukan bahwa terjadi peningkatan hasil kekuatan otot quadriceps femoris setelah diberikan latihan dengan mengunakan metode isotonik dengan nilai t-hitung 15,16 Lebih besar dari nilai t-tabel 2,262. Selain itu, juga terjadi peningkatan hasil kekuatan otot quadriceps femoris setelah diberikan latihan dengan menggunakan metode isometrik dengan nilai t-hitung 17,15 lebih besar dari nilai t-tabel 2,262. Selain itu juga terjadi peningkatan otot lebih besar pada metode latihan isotonik disbanding metode latihan isometrik dengan nilai t-hitung 2,375 lebih besar dari t-tabel 2,101.
Kata Kunci : Kekuatan otot, Kontraksi otot, Metode latihan penguatan.
Liposclerosing Myxofibrous Tumor in a Patient with Prostate Cancer
Authors: Barnds Brandon , Grote Caleb , Mettman Daniel , Templeton Kimberly 
Published: December 2019

Case:
A 64-year-old man diagnosed with prostate cancer was incidentally found to have a lesion in his distal femur. Although initially concerning for metastatic prostate cancer, after biopsy by an orthopaedic oncology specialist, a diagnosis of liposclerosing myxofibrous tumor (LSMFT) was confirmed. The lesion was treated with curettage and demineralized bone matrix grafting with close follow-up.

Conclusions:
This case report illustrates that LSMFT is not confined to the proximal femur and highlights the differences in radiographic appearance between LSMFT and more common metastatic bone lesions.
Strengthening Community-Clinical Linkages to Reduce Cardiovascular Disease Risk in Rural NC: Feasibility Phase of the CHANGE Study
Authors: Samuel-Hodge Carmen D , Gizlice Ziya , Allgood Sallie D , Bunton Audrina J , Erskine Amber , Leeman Jennifer , Cykert Samuel 
Published: December 2019

Abstract

Background Community Health Workers (CHW) are recommended for delivery of interventions to prevent cardiovascular disease, but there is insufficient evidence to guide implementation of CHW interventions in rural, medically underserved areas.Methods Using a hybrid implementation-effectiveness design, we evaluated the implementation and effectiveness of an adapted, evidence-based cardiovascular disease risk reduction intervention among rural high-risk adults. CHWs at a community health center and local health department recruited, enrolled and counseled participants during 4 monthly home visits and 3 brief phone contacts. Participant data collection included pre- and post-intervention measurements of blood pressure, weight, and dietary and physical activity behaviors. We evaluated implementation with measures of intervention reach and delivery fidelity. Statistical analyses included descriptive statistics and paired t-tests.Results Study participants (n=105) had a mean age of 62 years and included 88% Non-Hispanic Blacks and 82% females. Recruitment strategies resulted in the enrollment of 38% of interested and eligible participants who received 80% of the planned intervention visits and phone contacts. Mean differences in pre-/post-intervention measures showed significant mean reductions in blood pressure (-5.4 mm Hg systolic, p=.006; -2.3 mm Hg diastolic, p=.04) and body weight (-3.8 lb., p=.02). Self-reported dietary and physical activity behaviors also improved significantly.Conclusion This feasibility study demonstrated preliminary implementation and program effectiveness of a CHW-delivered intervention to reduce cardiovascular disease risk factors. Additionally, it identified areas for future refinements to strategies that strengthen community-clinical linkages with an integrated role of CHWs in rural health care delivery. If results from this feasibility study can be enhanced in a larger sample, there would be significant potential to positively impact the excess burden of chronic diseases that adversely impact rural, low-income, and medically underserved populations.
Cost-Effectiveness of Pain Management Services for Chronic Low Back Pain: A Systematic Review of Published Studies
Authors: Almazrou Saja , Elliott Rachel A , Knaggs Roger D , AlAujan Shiekha S 
Published: December 2019

Abstract
Background: Chronic low back pain (CLBP) is a highly prevalent condition that has substantial impact on patients, the healthcare system and society. Pain management services (PMS), which aim to address the complex nature of back pain, are recommended in clinical practice guidelines to manage CLBP. Although the effectiveness of such services has been widely investigated in relation to CLBP, the quality of evidence underpinning the use of these services remains moderate. Therefore the aim is to summarize and critically appraise the current evidence for the cost effectiveness of pain management services for managing chronic back pain. Methods: Electronic searches were conducted in MEDLINE, EMBASE and PsycINFO from their inception to February 2019. Full economic evaluations undertaken from any perspective conducted alongside randomized clinical trials (RCTs) or based on decision analysis models were included. Cochrane Back Review Group (CBRG) risk assessment and the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist were used to assess the methodological quality of eligible studies. Results: Five studies fulfilled eligibility criteria. The interventions varied significantly between studies in terms of the number and types of treatment modalities, intensity and the duration of the program. Interventions were compared with either standard care, which varied according to the country and the setting; or to surgical interventions. Three studies showed that pain management services are cost effective, while two studies showed that these services are not cost effective. In this review, three out of five studies had a high risk of bias based on the design of the randomised controlled trials (RCTs). In addition, there were limitations in the statistical and sensitivity analyses in the economic evaluations. Therefore, the results from these studies need to be interpreted with caution. Conclusion Pain management services may be cost effective for the management of low back pain. However, this systematic review highlights the variability of evidence supporting pain management services for patients with back pain. This is due to the quality of the published studies and the variability of the setting, interventions, comparators and outcomes.
Effectiveness of the Healthy Start-Départ Santé approach on physical activity, healthy eating and fundamental movement skills of preschoolers attending childcare centres: A randomized controlled trial
Authors: Leis Anne , Ward Stéphanie , Vatanparast Hassan , Humbert Louise , Chow Amanda Froehlich , Muhajarine Nazeem , Engler-Stringer Rachel , Bélanger Mathieu 
Published: December 2019

Abstract

Background: Since young children spend approximately 30 hours per week in early childcare centres (ECC), this setting is ideal to foster healthy behaviors. This study aimed to asses the effectiveness of the Healthy Start-Départ Santé (HSDS) randomized controlled trial in increasing physical activity (PA) levels and improving healthy eating and fundamental movement skills in preschoolers attending ECC. Methods: Sixty-one ECC were randomly selected and allocated to either the usual practice (n=30; n=433 children) or intervention group (n=31; n=464 children). The HSDS intervention group was provided a 3-hour on-site training for childcare educators which aimed to increase their knowledge and self-efficacy in promoting healthy eating, PA and development of fundamental movement skills in preschoolers. PA was measured during childcare hours for five consecutive days using the Actical accelerometer. Preschoolers’ fundamental movement skills were assessed using the standard TGMD-II protocol and POMP scores. Food intake was evaluated using digital photography-assisted weighted plate waste at lunch, over two consecutive days. All data were collected prior to the HSDS intervention and again 9 months later. Mixed-effect models were used to analyse the effectiveness of the HSDS intervention on all outcome measures. Results: Total number of children who provided valid data at baseline and endpoint for PA, food intake and fundamental movement skills were 259, 670 and 492, respectively. Children in the HSDS intervention group had, on average, a 3.33 greater point increase in their locomotor motor skills scores than children in the control group (β=3.33, p=0.009). No significant differences in effects were observed for object control, PA and food intake. However, results demonstrated a marginal increase in portions of fruits and vegetables served in the intervention group compared to control group (β=0.06, p=0.05). Conclusion: Locomotor skills showed a significant improvement in the intervention group compared to the control one. Although modest beneficial effects of HSDS were found, most outcome indicators progressed in a direction favouring the HSDS intervention compared to the usual practice group.
Mitochondrial localization of Dictyostelium discoideum dUTPase mediated by its N-terminus
Authors: Chia Catherine , Inoguchi Noriko , Varon Kyle C. , Bartholomai Bradley M. , Moriyama Hideaki 
Published: December 2019

Abstract
Objective The nuclear and mitochondrial genomes of Dictyostelium discoideum , a unicellular eukaryote, have relatively high A+T-contents of 77.5% and 72.65%, respectivey. To begin to investigate how the pyrimidine biosynthetic pathway fulfills the demand for dTTP, we determined the catalytic properties and structure of the key enzyme deoxyuridine triphosphate nucleotidohydrolase (dUTPase) that hydrolyzes dUTP to dUMP, the precursor of dTTP. Results The annotated genome of D. discoideum identifies a gene encoding a polypeptide containing the five conserved motifs of homotrimeric dUTPases. Recombinant proteins, comprised of either full-length or core polypeptides with all conserved motifs but lacking residues 1-37 of the N-terminus, were active dUTPases. Crystallographic analyses of the core enzyme indicated that the C-termini, normally flexible, were constrained by interactions with the truncated N-termini. This allowed greater access of dUTP to active sites, resulting in enhanced catalytic parameters. A tagged protein comprised of the N-terminal forty amino acids of dUTPase fused to green fluorescent protein (GFP) was expressed in D. discoideum cells. Supporting a prediction of mitochondrial targeting information within the N-terminus, localization and subcellular fractionation studies showed GFP to be in mitochondria. N-terminal sequencing of immunoprecipitated GFP revealed the loss of the dUTPase sequence upon import into the organelle.
An artificially simulated outbreak of a respiratory infectious disease
Authors: Author) Zuiyuan Guo(Former Corresponding , Xu Shuang , Tong Libo , Dai Botao , Author) Yuandong Liu(New Corresponding , Dan Xiao 
Published: December 2019

Abstract
Background Outbreaks of respiratory infectious diseases often occur in crowded places. To understand the pattern of spread of an outbreak of a respiratory infectious disease and provide a theoretical basis for targeted implementation of scientific prevention and control, we attempted to establish a stochastic model to simulate an outbreak of a respiratory infectious disease at a military camp. This model fits the general pattern of disease transmission and further enriches theories on the transmission dynamics of infectious diseases.Methods We established an enclosed system of 500 people exposed to adenovirus type 7 (ADV 7) in a military camp. During the infection period, the patients transmitted the virus randomly to susceptible people. The spread of the epidemic under militarized management mode was simulated using a computer model named “the random collision model”, and the effects of factors such as the basic reproductive number (R0), time of isolation of the patients (TOI), interval between onset and isolation (IOI), and immunization rates (IR) on the developmental trend of the epidemic were quantitatively analysed. Results Once the R0 exceeded 1.5, the median attack rate increased sharply; when R0=3, with a delay in the TOI, the attack rate increased gradually and eventually remained stable. When the IOI exceeded 2.3 days, the median attack rate also increased dramatically. When the IR exceeded 0.5, the median attack rate approached zero. The median generation time was 8.26 days, (95% confidence interval [CI]: 7.84-8.69 days). The partial rank correlation coefficients between the attack rate of the epidemic and R0, TOI, IOI, and IR were 0.61, 0.17, 0.45, and -0.27, respectively. Conclusions The random collision model not only simulates how an epidemic spreads with superior precision but also allows greater flexibility in setting the activities of the exposure population and different types of infectious diseases, which is conducive to furthering exploration of the epidemiological characteristics of epidemic outbreaks.
Predictors of multimorbidity among the Kurdish population living in the Northwest of Iran
Authors: Aminisani Nayyereh , Rastgou Laven , Shamshirgaran Seyed Morteza , Sarbakhsh Parvin , Ghaderi Shadi , Hyde Martin 
Published: December 2019

Abstract
Background: There is limited information about the predictors of multimorbidity (MM) among ethnic minority older adults in Iran. This study aimed to examine the impact of sociodemographic and lifestyle factors on the prevalence of MM, among older Kurdish people living in the Northwest of Iran. Methods: The current study was conducted in Bukan city located in West Azarbaijan province in the Northwest of Iran. Stratified random sampling was used to select people aged 50 + from eight health centres in Bukan from Oct 2017 to Dec 2018. Those who accepted the invitation and completed the baseline questionnaire were included in this study (N=1493; Response rate 75%). A range of different factors, including sociodemographic and lifestyle factors as well as self-reported chronic conditions, was obtained by trained interviewers. MM was defined as “coexistence of two or more chronic conditions in the same person”. Descriptive analysis and logistic regression were performed to compare the prevalence of MM according to different factors. Results: Over a third of the participants (36.6%) had ≥2 chronic conditions and 15.7% had ≥3 chronic conditions. Hypertension, diabetes, musculoskeletal conditions, fatty liver, and heart diseases were common chronic conditions. In a fully adjusted logistic regression model, older age (ORadj=1.92, 95% CI: 1.48-2.48), being female (ORadj=1.49, 95%CI: 1.14-1.94), living without a spouse (ORadj=1.81, 95%CI: 1.34-2.44), and inadequate consumption of fruit and vegetables (ORadj=1.33, 95%CI: 1.06-1.67) were associated with the higher prevalence of MM. Conclusion: This study found that the prevalence of MM is relatively high among older Kurdish adults. Sociodemographic differences in the prevalence of MM might be of interest to the health care system, and the prevalence of common chronic conditions in this study may highlight the need for lifestyle modifications in this community.
Anticholinergics and Benzodiazepines on Cognitive Impairment among Elderly with Alzheimer’s Disease: a One year Follow-Up Study
Authors: Jenraumjit Rewadee , Chinwong Surarong , Chinwong Dujrudee , Kanjanarach Tipaporn , Kshetradat Thanat , Wongpakaran Tinakon , Wongpakaran Nahathai 
Published: December 2019

Abstract
Objective
Age-associated decline in central cholinergic activity makes older adults susceptible to harmful effects of anticholinergics (ACs). Evidence exists of an association between effects of AC medications on cognition. This retrospective cohort study examines how ACs affect cognition among older adults with Alzheimer’s disease (AD) who received acetylcholine esterase inhibitors (AChEIs) over the course of 12 months.

Results
A total of 133 (80% women, mean age 78.38 years, SD 7.4) were recruited. No difference in sex, age and comorbid diseases was observed between participants who took ACs, Benzodiazepines (BZDs) and AChEIs. The most common prescribed ACs was quetiapine, being used for behavioral and psychological symptoms (BPSD). Multilevel analysis showed that the change of mental state examination scores were significantly predicted in the group using ACs ( t (169), -2.52, p = .020) but not with the groups using BZD ( t (162), 0.84, p = .440). Evidence showed that older adults with Alzheimer’s disease and exposed to ACs exhibited lower global cognitive scores than those without AC exposure. Using ACs could be a trade-off between controlling BPSD and aggravating cognitive impairment. Highlighting the awareness of the potential anticholinergic effect is important and may be the best policy.
Weight Development Between Age 5 And 10 Years And Its Associations With Dietary Patterns At Age 5 In The ABCD Cohort
Authors: Rashid Viyan , Streppel Martinette T , Engberink Marielle F. , Weijs Peter J.M. , Nicolaou Mary , Verhoeff Arnoud P. 
Published: December 2019

Abstract
Background: Social inequalities in bodyweight start early in life and track into adulthood. Dietary patterns are an important determinant of weight development in children, towards both overweight and underweight. Therefore, we aimed to examine weight development between age 5 and 10 years by ethnicity, SES and thereafter by BMI category at age 5, to explore its association with dietary patterns at age 5.Methods: Participants were 1 765 children from the Amsterdam Born Children and their Development (ABCD) cohort that had valid data on BMI at age 5 and 10 and diet at age 5. Linear mixed model analysis was used to examine weight development between age 5 and 10 years and to assess if four previously identified dietary patterns at age 5 (snacking, full-fat, meat and healthy) were associated with weight development. Analyses were adjusted for relevant confounders, stratified by ethnicity and SES and thereafter stratified per BMI category at age 5.Results: Overall, weight decreased in Dutch and high SES children and increased in non-Dutch and low/middle SES children. Across the range of bodyweight categories at age 5, we observed a conversion to normal weight, which was stronger in Dutch and high SES children but less pronounced in non-Dutch and low/middle SES children. Overall, the observed associations between weight development and dietary patterns were mixed with some unexpected findings: a healthy dietary pattern was positively associated with weight development in most groups, regardless of ethnicity and SES (e.g. Dutch B 0.084, 95% CI 0.038;0.130 and high SES B 0.096, 95% CI 0.047;0.143) whereas the full-fat pattern was negatively associated with weight development (e.g. Dutch B -0.069, 95% CI -0.114;-0.024 and high SES B -0.072, 95% CI -0.119;-0.026). Conclusions: We observed differential weight development per ethnic and SES group. Our results indicate that each ethnic and SES group follows its own path of weight development. Associations between dietary patterns and weight development showed some unexpected findings; follow-up research is needed to understand the association between dietary patterns and weight development. Keywords: BMI, body mass index, thinness, normal weight, overweight, obesity, socio-economic position, ethnicity, children, young children.
Diabetics’ self-care practice and its determinants among Adult diabetic patients in Ethiopia: A systematic review and meta-analysis.Diabetics’ self-care practice and its determinants among Adult diabetic patients in Ethiopia: A systematic review and meta-analysis
Authors: Yehualashet Fikadu Ambaw , Takele Wuber Worku , Tegegne Eleni Tesfaye , Ayele Amare Demsie 
Published: December 2019

Abstract
Background Appropriate diabetic self-care is indispensable to prevent and limit diabetic associated short and long term complications including death. Despite the well-recorded devastating complications of diabetes mellitus, a pooled percentage of diabetic patients applying self-care and its determinants at the national level have remained unknown. Therefore, this comprehensive systematic review and meta-analysis is aimed at determining the pooled national percentage of diabetic self-care practice and its determinants among adult diabetic patients in Ethiopian. Methods: Different electronic databases including PubMed/Medline and search engines such as Google scholar were used to retrieve published studies. The Joanna Briggs Institute quality appraisal checklists were used to appraise the quality of studies. Data were extracted using excel spreadsheets and analyses were done by STATA 14. Heterogeneity among studies was diagnosed using the I2 test. The DerSimonian and Laird random-effects model was employed for substantial heterogeneity (I2>50%). The pooled estimate of diabetic self-care and odds ratio was reported based on the 95% CI. Results: A total of 3861 studies were identified, of which only 19 studies have reached the final qualitative synthesis and quantitative analysis. Well over half of the Ethiopian diabetic patients have good self-care 54.04% (47.07-61.01, I2 =97.3, P<0.001). Subgroup analysis showed that the highest pooled estimate was in Southern Nations Nationalities and Peoples 81.96(71.85-92.04), I2=89.1, P<0.002) while the lowest was from the Hareri region 44.53(32.16-56.89) I2=94%%, P<0.001). Being knowledgeable about diabetes mellitus 2.69 (1.62, 4.46; I2 =99%, P<0.001), having good social support 2.25(1.49-3.39; I2=99%, P=0.00), owning private glucometer 3.04(1.64, 5.65; I2=97.4, P<0.001), and being urban residents 3.26(2.24, 4.74; I2=96.3%, P<0.001) have promoted diabetic victims to apply self-care practice. Conclusions: Despite the life-threatening complications of diabetes mellitus, the percentage of patients applying self-care has remained low in Ethiopia, depicting the high proportion of diabetic patients are prone to develop long and short term complications of diabetes mellitus. Therefore, improving the client’s awareness about the disease and counseling clients about the significance of social support are believed to be possible strategies to improve self-care practice and policymakers are strongly recommended to combat complications to attain sustainable development goal 3.4 aims to reduce premature death.