bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Feasibility Trial of a Novel Strategy of Facilitated Cascade Genetic Testing Using Telephone Counseling
Authors: Frey Melissa K. , Kahn Ryan M. , Chapman-Davis Eloise , Tubito Francesca , Pires Maira , Christos Paul , Anderson Samantha , Mukherjee Semanti , Jordan Bailey , Blank Stephanie V. , Caputo Thomas A. , Sharaf Ravi N. , Offit Kenneth , Holcomb Kevin , Lipkin Steven 
Published: January 2020

PURPOSE A powerful consequence of detecting cancer-associated pathogenic variants is the ability to test at-risk relatives (ARRs), termed cascade testing. However, historical studies suggest cascade testing uptake of 30% or less. Here, we tested the feasibility of a novel, streamlined method of cascade testing using telephone genetic counseling and mailed saliva-based genetic testing. PATIENTS AND METHODS Probands with newly diagnosed cancer-associated pathogenic variants were offered facilitated cascade testing whereby the genetics team identified and contacted ARRs by telephone to disclose the familial pathogenic variant and offer telephone counseling and mailed saliva testing. Results and guideline-based recommendations were reviewed by telephone and shared with the primary care physician. RESULTS Thirty probands were enrolled, and 114 ARRs were identified. Twelve ARRs were excluded (lived outside of the United States, n = 5; proband did not approve of contact, n = 7). Among 102 ARRs telephoned, contact was established with 95 (93%). Among 114 identified ARRs, 66 (58%) completed genetic testing. Among those completing testing, 27 (41%) carried the familial pathogenic variant. Surveys of ARRs at the time of genetic testing and 6 months later demonstrated low levels of anxiety, depression, distress, and uncertainty and high levels of satisfaction with testing. At 6 months, 7 ARRs with pathogenic variants had undergone cancer surveillance interventions and 4 had undergone cancer risk-reducing surgery. CONCLUSION Facilitated cascade testing with telephone genetic counseling and mailed saliva kits resulted in high testing uptake among ARRs. Positive genetic testing resulted in utilization of genetically targeted primary disease prevention at short-term follow-up. Facilitated cascade testing is a straightforward, low-cost, easily implemented strategy with significant potential to promote early detection for affected ARRs and reduce cancer mortality and should be evaluated in larger scale clinical trials.
A Multinational Observational Study Exploring Adherence With the Kidney Disease: Improving Global Outcomes Recommendations for Prevention of Acute Kidney Injury After Cardiac Surgery
Authors: Küllmar Mira , Weiß Raphael , Ostermann Marlies , Campos Sara , Grau Novellas Neus , Thomson Gary , Haffner Michael , Arndt Christian , Wulf Hinnerk , Irqsusi Marc , Monaco Fabrizio , Di Prima Ambra Licia , García-Alvarez Mercedes , Italiano Stefano , Felipe Correoso Mar , Kunst Gudrun , Nair Shrijit , L’Acqua Camilla , Hoste Eric , Vandenberghe Wim , Honore Patrick M. , Kellum John A. , Forni Lui , Grieshaber Philippe , Wempe Carola , Meersch Melanie , Zarbock Alexander 
Published: January 2020

BACKGROUND:
The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend a bundle of different measures for patients at increased risk of acute kidney injury (AKI). Prospective, single-center, randomized controlled trials (RCTs) have shown that management in accordance with the KDIGO recommendations was associated with a significant reduction in the incidence of postoperative AKI in high-risk patients. However, compliance with the KDIGO bundle in routine clinical practice is unknown.

METHODS:
This observational prevalence study was performed in conjunction with a prospective RCT investigating the role of the KDIGO bundle in high-risk patients undergoing cardiac surgery. A 2-day observational prevalence study was performed in all participating centers before the RCT to explore routine clinical practice. The participating hospitals provided the following data: demographics and surgical characteristics, AKI rates, and compliance rates with the individual components of the bundle.

RESULTS:
Ninety-five patients were enrolled in 12 participating hospitals. The incidence of AKI within 72 hours after cardiac surgery was 24.2%. In 5.3% of all patients, clinical management was fully compliant with all 6 components of the bundle. Nephrotoxic drugs were discontinued in 52.6% of patients, volume optimization was performed in 70.5%, 52.6% of the patients underwent functional hemodynamic monitoring, close monitoring of serum creatinine and urine output was undertaken in 24.2% of patients, hyperglycemia was avoided in 41.1% of patients, and no patient received radiocontrast agents. The patients received on average 3.4 (standard deviation [SD] ±1.1) of 6 supportive measures as recommended by the KDIGO guidelines. There was no significant difference in the number of applied measures between AKI and non-AKI patients (3.2 [SD ±1.1] vs 3.5 [SD ±1.1]; P = .347).

CONCLUSIONS:
In patients after cardiac surgery, compliance with the KDIGO recommendations was low in routine clinical practice.
Molecular Design and Regulation of Metalloenzyme Activities through Two Novel Approaches: Ferritin and P450s
Authors: Watanabe Yoshihito , Aiba Yuichiro , Ariyasu Shinya , Abe Satoshi 
Published: January 2020

Abstract
We have developed two novel approaches for the construction of artificial metalloenzymes showing either unique catalytic activities or substrate specificity. The first example is the use of a hollow cage of apo-ferritin as a reaction vessel for hydrogenation of olefins, Suzuki-Miyaura C-C coupling and phenylacetylene polymerization by employing Pd0 nano-clusters, Pd2+(η3-C3H5) complexes and Rh1+(nbd) (nbd = norbornadiene) complexes introduced in the hollow cage, respectively. The second approach is the use of “decoy molecules” to change substrate specificity of P450s, allowing epoxidation and hydroxylation activities toward nonnative organic substrates in P450SPα, P450BSβ and P450BM3 without the mutation of any amino acid. Finally, the decoy strategy has been applied to an in vivo system of P450, i.e., the use of P450BM3 expressed in the whole cell of E. coli to oxidize benzene to phenol.
Quality of Single-Case Designs Targeting Adults’ Exercise and Physical Activity: A Systematic Review
Authors: Ferrara Paula-Marie M. , Beaumont Cory T. , Strohacker Kelley 
Published: January 2020

ABSTRACT
Exercise and physical activity (ExPA) interventions require substantial preefficacy and efficacy testing before dissemination at the clinical and community level. Single-case designs (SCD; i.e., small-scale experiments where participants serve as their own controls) hold promise for preefficacy intervention development and refinement. At present, SCD may be underutilized in ExPA promotion, potentially because of the perceived lack of methodological rigor.

Purpose
This review aimed to evaluate the quality of SCD research used to test ExPA promotion strategies in adults.

Methods
Combinations of key words related to SCD and ExPA were used to search PubMed, Web of Science, and PsycINFO between July and October 2017. Of the 120 individual searches, 1227 titles were found, 10 of which met inclusion criteria. Two published quality assessment tools were then used to analyze SCD quality.

Results
Average quality scores were 10 out of 14 (range 8–12) for the first tool and 13 out of 15 (range 9–15) for the second tool. Commonly unmet criteria included the use of assessor blinding (unfulfilled by 100% of studies), fidelity reporting (unfulfilled by 100%), inter-/intrarater reliability (unfulfilled by 80%), and appropriate statistical analyses (unfulfilled by 60%).

Conclusion
Quality scores of SCD reporting were moderate to strong, but commonly missed criteria represent rigorous reporting standards for behavioral science. Although not specifically addressed in the quality assessment tools, it is important to note that only one study reported the ExPA prescription with replicable precision (i.e., specific reporting of exercise frequency, intensity, time, type, volume, and progression). Researchers should strive to meet all criteria and provide transparency to elevate the use of SCD for ExPA intervention development before effectiveness testing in real-world conditions.
Animal utilization based on local knowledge in Ciletuh Geopark, Ciemas Subdistrict, Sukabumi, West Java, Indonesia
Authors: INDRI WULANDARI  , Shanida Sya Sya , TEGUH HUSODO  , ERRI NOVIAR MEGANTARA  , DEDE TRESNA  
Published: January 2020

Abstract. Wulandari I, Shanida SS, Husodo T, Megantara EN, Tresna D. 2019. Animal utilization based on local knowledge in Ciletuh Geopark, Ciemas Subdistrict, Sukabumi, West Java, Indonesia. Biodiversitas 20: 2781-2789. Ciletuh Geopark has high biodiversity but has not been supported by local knowledge about the use of animals to support sustainable development. This study aims to investigate: (i) the number of species that are used, (ii) distribution of local knowledge about animals using, and (iii) the dependency of communities on creatures in Ciletuh Geopark, Ciemas Subdistrict, Sukabumi. Mixed methods of qualitative (semi-structured interviews) and quantitative methods (proportional random sampling) were applied in this study. The community uses 153 species, consisting 58 Avifauna species, 13 mammals species, nine Herpetofauna species, three insects species, 16 species of freshwater fish, 43 species of seawater fish, two Mollusca species, and nine crustacean species. Utilization of fauna is not distributed in each village. Animals using of Avifauna, Herpetofauna, insects, and mammals tend to be utilized by people of Girimukti Village. Seawater fish, Mollusca, and crustaceans tend to be utilized by Ciwaru Village, while freshwater fish tend to be used in each village, except Girimukti and Cibenda Village. Utilization of fauna in Ciemas Subdistrict has begun to be abandoned, although several people still use them.
The phytoremediation potential of non-edible oil-producing plants for gold mine tailings
Authors: Andriya Nadya Nurafifah , Hamim Hamim , SULISTIJORINI SULISTIJORINI , Triadiati Triadiati 
Published: January 2020

Abstract. Andriya NN, Hamim H, Sulistijorini, Triadiati. 2019. The phytoremediation potential of non-edible oil-producing plants for gold mine tailings. Biodiversitas 20: 2949-2957. Plants can be used as phytoremediation agents to reduce environmental pollutants including heavy metal contaminants produced due to industrial activities. The objective of this study was to analyze the morphological, anatomical, and physiological responses of four non-edible oil-producing plants namely Jatropha curcas, Ricinus communis, Reutealis trisperma, and Melia azedarach and their ability to absorb and accumulate lead (Pb) when grown in different concentrations of gold mine tailings. The study was conducted using a completely randomized design involving two factors, four different species of plants and three different concentrations of tailings (0%, 50%, and 100%). Gold mine tailings caused a decrease in the growth of all species indicated by a significant reduction in plant height, leaf number, leaf area, shoot as well as root dry weight, while it significantly increased green RGB values of leaves. Pb accumulation was detected in the root as well as leaf tissues of the plant-based on histochemical analysis. The treatment with tailings also caused an increase in lipid peroxidation levels as indicated by increased malondialdehyde content in the roots and leaves. On the other hand, chlorophyll and carotenoid content decreased due to tailings treatment, along with the relative water content. Among the four species investigated, R. trisperma was found to be the most resistant species to gold mine tailings based on its ability to maintain growth even during gold tailing stress, which is also supported by principal component analysis.
Sodium lidar observation over full diurnal cycles in Beijing, China
Authors: Xia Yuan , Cheng XueWu , Li FaQuan , Yang Yong , Lin Xin , Jiao Jing , Du LiFang , Wang JiHong , Yang GuoTao 
Published: January 2020

Due to the severe interference from strong solar background light on the received signal, daytime ground-based lidar observation of the sodium (Na) layer is challenging. In this paper, a Na lidar permitting full-diurnal-cycle observation of the metal Na layer over Beijing, China (40.5°N, 116°E) was reported. In order to suppress the skylight background during daytime effectively with less signal losses, a dual-channel Faraday filtering unit was implemented in the lidar receiver. Based on the diurnal Na lidar system, a good number of continuous observational results that lasted more than 120 h with good signal-to-noise ratio were obtained, demonstrating its reliability. Considerable variations within the Na layer during the day were revealed, especially on the layer top and bottom side. In particular, strong sporadic Na layer (Nas) events that occurred during the daytime of 3 consecutive days were also captured with complete evolution process. These observational results showed the advantages of the diurnal Na lidar for investigating the metal layer photochemistry and dynamics in the mesosphere and lower thermosphere region. Na layer observations over the whole diurnal cycle not only benefit the improvements of current theoretical models, but also can allow for a specialized analysis of Nas that occur in the daytime and provide valuable observational support for investigating the rapid production and disappearance mechanisms of Na atoms.
Compact plasmonic fiber tip for sensitive and fast humidity and human breath monitoring
Authors: Du Bobo , Yang Dexing , Ruan Yinlan , Jia Peipei , Ebendorff-Heidepriem Heike 
Published: January 2020

We demonstrate a plasmonic fiber tip for relative humidity (RH) detection by integrating a gold nanomembrane onto the end-face of a multimode optical fiber via a flexible and high-efficiency transfer method. Fast water condensation/evaporation is responsible for the high performance of the fiber tip in response to RH. A high sensitivity of 279 pm/%RH is obtained in the range of

11
%
∼
92
%

R
H

. Taking advantage of the fast dynamics (response and recovery times of 156 ms and 277 ms), the plasmonic fiber tip offers an excellent detection capability to human breaths at varied frequencies and depths. The compact, easy-fabrication, and fast-dynamics plasmonic platform has versatile potential for practical applications, including environmental and healthcare monitoring, as well as biochemical sensing.
Ultrafast laser-absorption spectroscopy for single-shot, mid-infrared measurements of temperature, CO, and CH4 in flames
Authors: Tancin Ryan J. , Chang Ziqiao , Gu Mingming , Radhakrishna Vishnu , Lucht Robert P. , Goldenstein Christopher S. 
Published: January 2020

This Letter describes the development of an ultrafast (i.e., femtosecond), mid-infrared (mid-IR), laser-absorption diagnostic and its initial application to measuring temperature, CO, and

C
H

4

in flames. The diagnostic employs a Ti:sapphire oscillator emitting 55 fs pulses near 800 nm that were amplified and converted into the mid-IR though optical parametric amplification at a repetition rate of 5 kHz. The pulses were directed through the test gas and into a high-speed mid-IR spectrograph to image spectra across a

≈

30

n
m

bandwidth with a spectral resolution of

≈

0.3

n
m

. Gas properties were determined by least-squares fitting simulated absorbance spectra to measured single-shot absorbance spectra. The diagnostic was validated with measurements of temperature, CO, and

C
H

4

in a static-gas cell with an accuracy of 0.7% to 1.8% of known values. Single-shot, 5 kHz measurements of temperature and CO column density were acquired near 4.9 µm in a laser-ignited HMX (i.e., 1,3,5,7-tetranitro-1,3,5,7-tetrazoctane) flame and exhibited

1
−
σ

precisions of 0.4% and 2.3%, respectively, at

≈

2700

K

. Further, temperature and

C
H

4

column density measurements were acquired near 3.3 µm in a partially premixed

C
H

4

-air flame produced by a Hencken burner and exhibited

1
−
σ

precisions of 0.3% and 1% respectively, at

≈

1000

K

.
Система государственного налогообложения городского недвижимого имущества в центральноазиатских окраинах Российской империи (конец XIX — начало ХХ в.)
Authors: Лысенко Юлия Александровна , Жанбосинова Альбина Советовна 
Published: January 2020

На основе документов делопроизводства органов власти Степного и Туркестанского генерал-губернаторств, а также статистических данных анализируется процесс формирования региональной модели государственного налогообложения на недвижимое городское имущество. Отмечается, что господство традиционных экономических отношений в центральноазиатских окраинах, незначительное присутствие в региональной экономике рыночного сектора и соответствующей ему городской инфраструктуры исключали возможность проведения здесь земской реформы и создания органов местного самоуправления — земств. Этот факт определил особенности формирования системы земских повинностей, в том числе налогообложения на городское недвижимое имущество. Данный налог начал вводиться в центральноазиатских окраинах гораздо позднее, чем в целом по империи — в конце XIX в., его распределение и контроль были возложены на областные и уездные правления. В условиях неравномерного роста численности городов и городских поселений в областях Степного края и Туркестана в пореформенный период введение государственного налога на городское недвижимое имущество происходило поэтапно.
Так, в Степном крае городское население стало выплачивать данный налог с момента введения Степного положения в 1891 г., в Туркестане — только с 1905 г.
Следует отметить, что суммы, поступаемые от сбора налога на недвижимое имущество, были незначительными и не могли в полном финансовом объеме обеспечить инфраструктурное и социальное развитие городов и городских поселений центральноазиатских окраин Российской империи.
Atuação do professor de psicologia em foco
Authors: Silva Pollyane Lisita , Silva Elilany Elias , Silva Janaína Cassiano , Campos Maurício 
Published: January 2020

O presente trabalho descreve a prática de estágio de licenciatura em Psicologia realizada com alunos do segundo ano do ensino fundamental em uma escola municipal situada em uma região periférica de uma cidade do sudeste goiano. Embora a temática trabalhada seja referente à preservação ambiental, foi possível tangenciar vários temas pertinentes à Psicologia, especificamente no encontro com a Educação, o que reafirma a contribuição do licenciado neste saber e, no acompanhamento, observação da turma, bem como nas três regências realizadas. O licenciado em Psicologia encontra por vezes dificuldades em diferenciar sua prática daquela do profissional de Psicologia Escolar, assim, buscou-se discutir uma prática contextualizada, utilizando-se para isso a referida atuação em licenciatura e suscitando questionamentos pertinentes à mesma.
The politicization of otherness and the privatization of the enemy: Cultural hindrances and assets for active citizenship
Authors: Mannarini Terri , Salvatore Sergio 
Published: January 2020

Abstract
The purpose of the article is to discuss the cultural hindrances and assets that promote constructive self-to-others relationships and active citizenship. Building on Carl Schmitt’s friend-enemy distinction, we argue that in contemporary societies the public and the private dimensions of the enemy have conflated, as the result of two concurrent phenomena: the politicization of otherness and the privatization of enemies. An integrated framework including approaches of social psychology and semiotic cultural psychology is proposed to account for both phenomena. The notions of symbolic universes and semiotic capital are introduced as key concepts to understand the current socio-political dynamics and to promote fairer, more inclusive societies.
Tort’s Indifference: Conformity, Compliance, and Civil Recourse
Authors: Azmat Ahson 
Published: January 2020

AbstractLeading accounts of tort law split cleanly into two seams. Some trace its foundations to a deontic form of morality; others to an instrumental, policy-oriented system of efficient loss allocation. An increasingly prominent alternative to both seams, Civil Recourse Theory (CRT) resists this binary by arguing that tort comprises a basic legal category, and that its directives constitute reasons for action with robust normative force. Using the familiar question whether tort’s directives are guidance rules or liability rules as a lens, or prism, this essay shows how considerations of practical reasoning undermine one of CRT’s core commitments. If tort directives exert robust normative force, we must account for its grounds—for where it comes from, and why it obtains. CRT tries to do so by co-opting H.L.A. Hart’s notion of the internal point of view, but this leveraging strategy cannot succeed: while the internal point of view sees legal directives as guides to action, tort law merely demands conformity. To be guided by a directive is to comply with it, not conform to it, so tort’s structure blocks the shortcut to normativity CRT attempts to navigate. Given the fine-grained distinctions the theory makes, and with the connection between its claims and tort’s requirements thus severed, CRT faces a dilemma: it’s either unresponsive to tort’s normative grounds, or it’s inattentive to tort’s extensional structure.
Performative speech act verbs and sincerity in Anglo-Norman and Middle English letters
Authors: Williams Graham Trevor 
Published: January 2020

AbstractThis paper investigates performative manifestations of sincerity across Anglo-Norman and Middle English. In particular, it locates adverbial sincerity markers used to qualify performative speech act verbs in late medieval letters (fourteenth and fifteenth centuries), at a point when Middle English was rapidly replacing Anglo-Norman as the vernacular of epistolarity in England. Employing historical dictionaries and corpora, the study 1) locates the range of words for ‘sincerity’ from a time when the modern lexeme had yet to be borrowed in either vernacular, and 2) demonstrates that while it is clear that Middle English epistolarity was greatly influenced by Anglo-Norman, quantitative and qualitative analyses suggest that sincerity markers were much less commonplace in Middle English performatives, which further suggests ways in which the communicative ideal and practice of sincerity were reanalyzed from one language to the next.
Chaos synchronization of fractional–order discrete–time systems with different dimensions using two scaling matrices
Authors: Ouannas Adel , Bendoukha Samir , Khennaoui Amina–Aicha , Grassi Giuseppe , Wang Xiong , Pham Viet-Thanh 
Published: January 2020

Abstract
In this paper, we study the synchronization of fractional–order discrete–time chaotic systems by means of two scaling matrices Θ and Φ. The considered synchronization scheme can be tailored to encompass several types of classical synchronization types. We proposed two nonlinear control strategies for the Θ–Φ synchronization of an m–dimensional drive system and an n–dimensional response system, whereby the synchronization dimension d = m and d = n, respectively. Numerical examples are presented to test the findings of the study.