bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID Term: A Bilingual Terminology for COVID-19
Authors: Ma Hetong , Shen Liu , Sun Haixia , Xu Zidu , Hou Li , Wu Sizhu , Fang An , Li Jiao , Qian Qing 
Published: October 2020

Abstract
Background: The coronavirus disease (COVID-19), a pneumonia caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has shown its destructiveness with more than one million confirmed cases and dozens of thousands of death, which is highly contagious and still spreading globally. World-wide studies have been conducted aiming to understand the COVID-19 mechanism, transmission, clinical features, etc. A cross-language terminology of COVID-19 is essential for improving knowledge sharing and scientific discovery dissemination.Methods: We developed a bilingual terminology of COVID-19 named COVID Term with mapping Chinese and English terms. The terminology was constructed as follows: (1) Classification schema design; (2) Concept representation model building; (3) Term source selection and term extraction; (4) Hierarchical structure construction; (5) Quality control (6) Web service. We built open access for the terminology, providing search, browse, and download services. Results: The proposed COVID Term include 10 categories: disease, anatomic site, clinical manifestation, demographic and socioeconomic characteristics, living organism, qualifiers, psychological assistance, medical equipment, instruments and materials, epidemic prevention and control, diagnosis and treatment technique respectively. In total, COVID Terms covered 464 concepts with 724 Chinese terms and 887 English terms. All terms are openly available online (COVID Term URL: http://covidterm.imicams.ac.cn ). Conclusions: COVID Term is a bilingual terminology focused on COVID-19, the epidemic pneumonia with a high risk of infection around the world. It will provide updated bilingual terms of the disease to help health providers and medical professionals retrieve and exchange information and knowledge in multiple languages. COVID Term was released in machine-readable formats (e.g., XML and JSON), which would contribute to the information retrieval, machine translation and advanced intelligent techniques application. Keywords: COVID-19, Terminology System, Bilingual, Medical Terminology
The association between obesity and weight loss after bariatric surgery on the vaginal microbiota
Authors: Raglan Olivia , MacIntyre David A. , Mitra Anita , Lee Yun S. , Smith Ann , Assi Nada , Nautiyal Jaya , Purkayastha Sanjay , Gunter Marc J , Gabra Hani , Marchesi Julian R. , Bennett Phillip R. , Kyrgiou Maria 
Published: October 2020

Abstract
Background: Obesity and vaginal microbiome (VMB) dysbiosis are each risk factors for adverse reproductive and oncological health outcomes in women. Here we investigated the relationship between obesity, vaginal bacterial composition, local inflammation and bariatric surgery.Methods: Vaginal bacterial composition assessed by high-throughput sequencing of bacterial 16S rRNA genes and local cytokine levels measured using a multiplexed Magnetic Luminex Screening Assay were compared between 67 obese and 42 non-obese women. We further assessed temporal changes in the microbiota and cytokines in a subset of 27 women who underwent bariatric surgery. Results: The bacterial component of the vaginal microbiota in obese women was characterised by a lower prevalence of a Lactobacillus-dominant VMB and higher prevalence of a high diversity (Lactobacillus spp., and Gardnerella- spp. depleted) VMB, compared with non-obese subjects (p<0.001). Obese women had higher relative abundance of Dialister species (p<0.001), Anaerococcus vaginalis (p=0.021) and Prevotella timonensis (p=0.020) and decreased relative abundance of Lactobacillus crispatus (p=0.014). Local vaginal IL-1β, IL-4, IL-6, IL-8, IFNγ, MIP-1α, and TNFα levels were all higher among obese women, however only IL-1β and IL-8 correlated with VMB species diversity. In a subset of obese women undergoing bariatric surgery, there were no significant overall differences in VMB following surgery, however 75% of these women remained obese at six months. Prior to surgery there was no relationship between body mass index (BMI) and VMB structure, however post-surgery women with a Lactobacillus-dominant VMB had a significantly lower BMI than those with a high diversity VMB.Conclusions: Obese women have a significantly different vaginal microbiota composition with increased levels of local inflammation compared to non-obese women. Bariatric surgery does not change the VMB, however, those with the greatest weight loss six-months post-surgery are most likely to have a Lactobacillus-dominant VMB.
Continuous Endometrial Volumetric Analysis for Endometrial Receptivity Assessment on Assisted Reproductive Technology Cycles
Authors: Martins Renato , Oliani Antonio Helio , Oliani Denise Vaz , de Oliveira Jose Martinez 
Published: October 2020

Abstract
Background: Human implantation is a complex process requiring synchrony between a healthy embryo and a functionally competent or receptive endometrium. In order to assess endometrial receptivity in Assisted Reproductive Technology (ART) cycles serial evaluation of endometrial volumetric analysis may have a predictive value on a positive outcome.Methods: Serial 3D transvaginal ultrasound performed in women on ART cycle to evaluate embryo implantation predictors. Prospective case control study of 169 subjects were assessed. Endometrial pattern, thickness, volume and adjusted endometrial volume (ratio between endometrial volume and uterine volume) was performed to all subjects on a continuous process from baseline, during controlled ovarian stimulation, trigger day with human chorionic gonadotropin hormone (hCG) and at embryo transfer day.Results: Demographics and ART procedures and scores, was similar between the two groups. Endometrial morphology also showed no difference between the two groups. Endometrial volume and adjusted endometrial volume was significantly higher in the positive group as soon as day 6 of ovarian controlled stimulation.Conclusions: Serial 3D endometrial volume and adjusted endometrial volumes provides a predicting clinical tool enhancing elective embryo transfers in fresh ART cycle. Thus providing a non-invasive continuous technique for endometrial receptivity assessment that reflects endometrial changes during ART procedures.
Polymorphisms in the airway epithelium related genes CDHR3 and EMSY are associated with asthma susceptibility
Authors: Zhang Miao-miao , Chen Guo , Wang Yu , Wu Shou quan , Sandford Andrew J , He Jian-Qing 
Published: October 2020

Abstract
Background: As a main line of defense of the respiratory tract, the airway epithelium plays an important role in the pathogenesis of asthma. CDHR3 and EMSY were reported to be expressed in the human airway epithelium. Although previous genome-wide association studies found that the two genes were associated with asthma susceptibility, similar observations have not been made in the Chinese Han population. Methods: A total of 300 asthma patients and 418 healthy controls unrelated Chinese Han individuals were enrolled. Tag-single nucleotide polymorphisms (Tag-SNPs) were genotyped and the associations between SNPs and asthma risk were analyzed by binary logistic regression analysis. Results: After adjusting for confounding factors, the A allele of rs3847076 in CDHR3 was associated with increased susceptibility to asthma (OR = 1.407, 95% CI: 1.030-1.923). For the EMSY gene, the T alleles of both rs2508746 and rs12278256 were related with decreased susceptibility to asthma (additive model: OR = 0.718, 95% CI: 0.536-0.961; OR = 0.558, 95% CI: 0.332-0.937, respectively). In addition, the GG genotype of rs1892953 showed an association with increased asthma risk under the recessive model (OR = 1.667, 95% CI: 1.104-2.518) and the GATCTGAGT haplotype in EMSY was associated with reduced asthma risk ( P = 0.037). Conclusions: This study identified novel associations of rs3847076 in CDHR3 , as well as rs1892953, rs2508746 and rs12278256 in EMSY with adult asthma susceptibility in the Chinese Han population. Our observations suggest that CDHR3 and EMSY may play important roles in the pathogenesis of asthma in Chinese individuals. Further study with larger sample size is needed.
Validation of Coronal Mass Ejection Arrival-Time Forecasts by Magnetohydrodynamic Simulations based on Interplanetary Scintillation Observations
Authors: Iwai Kazumasa , Shiota Daikou , Tokumaru Munetoshi , Fujiki Ken'ichi , Den Mitsue , Kubo Yûki 
Published: October 2020

Abstract
Coronal mass ejections (CMEs) cause various disturbances of the space environment; therefore, forecasting their arrival time is very important. However, forecasting accuracy is hindered by limited CME observations in interplanetary space. This study investigates the accuracy of CME arrival times at the Earth forecasted by three-dimensional (3D) magnetohydrodynamic (MHD) simulations based on interplanetary scintillation (IPS) observations. In this system, CMEs are approximated as spheromaks with various initial speeds. Ten MHD simulations with different CME initial speed are tested, and the density distributions derived from each simulation run are compared with IPS data observed by the Institute for Space-Earth Environmental Research (ISEE), Nagoya University. The CME arrival time of the simulation run that most closely agrees with the IPS data is selected as the forecasted time. We then validate the accuracy of this forecast using 12 halo CME events. The average absolute arrival-time error of the IPS-based MHD forecast is approximately 5.0 h, which is one of the most accurate predictions that ever been validated, whereas that of MHD simulations without IPS data, in which the initial CME speed is derived from white-light coronagraph images, is approximately 6.7 h. This suggests that the assimilation of IPS data into MHD simulations can improve the accuracy of CME arrival-time forecasts. The average predicted arrival times are earlier than the actual arrival times. These early predictions may be due to overestimation of the magnetic field included in the spheromak and/or underestimation of the drag force from the background solar wind, the latter of which could be related to underestimation of CME size or background solar wind density.
A standardized framework to evaluate the quality of studies using TDABC in healthcare: The TDABC in Healthcare Consortium Consensus Statement
Authors: Etges Ana Paula Beck da Silva , Polanczyk Carisi Anne , Urman Richard D. 
Published: October 2020

Abstract
Background: This Consensus Statement introduces a standardized framework, in a checklist format, to support future development and report of TDABC studies in healthcare, and to encourage their reproducibility. Additionally, it establishes the first formal networking of TDABC researchers through the creation of the TDABC for Health Care Consortium.Methods: A consensus group of researchers reviewed the most relevant TDABC studies available in Medline and Scopus databases to identify the initial elements of the checklist. Using a Focus Group process, each element received a recommendation regarding where in the scientific article section it should be placed and whether the element was required or suggested. A questionnaire was circulated with expert researchers in the field to provide additional recommendations regarding the content of the checklist and the strength of recommendation for each included element.Results: The TDABC standardized framework includes 32 elements, provides recommendations where in the scientific article to include each element, and the strength of each recommendation. All 32 elements were validated, with 21 elements classified as mandatory and 11 as suggested but not mandatory.Conclusions: This is the first standardized framework to support the development and reporting of TDABC research in healthcare and to stablish a community of experts in TDABC methodology. We expect that it can contribute to scale strategies that would result in cost-savings outcomes and in value-oriented strategies that can be adopted in healthcare systems and institutions.
Differences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients
Authors: Du Chunjing , Liu Jingyuan , Chen Hui , Yan Shuo , Pu Lin , Xiong Haofeng , Xiang Pan , Li Chuansheng , Zhang Ming , Xie Ruming , Chen Budong , Li Ang 
Published: October 2020

Abstract
Background: Accurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT ) features of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients and identify clinical hallmarks to accurately distinguish these two pathologies. Methods: A total of 112 AIDS patients (78 with pneumocystis pneumonia and 34 cytomegalovirus pneumonia) at Beijing Ditan Hospital from January 2017 to May 2019 were included in this study. Two experienced chest radiologists retrospectively reviewed CT images for 17 features including ground-glass opacity, consolidation, nodules, and halo sign. Binary logistic regression analyses were conducted to identify the significant parameters that distinguished pneumocystis pneumonia from cytomegalovirus pneumonia. Correlations were analyzed by Pearson or Spearman correlation analyses. Result were considered significant if P < 0.05. Results: The presence of consolidation, halo signs, and nodules (all P ＜0.05) were significantly more frequent in patients with cytomegalovirus pneumonia than in those with pneumocystis pneumonia. Small nodules (32.5% in cytomegalovirus pneumonia, 6.41% in pneumocystis pneumonia, P ＜0.001) without perilymphatic distribution were particularly common in patients with cytomegalovirus pneumonia. Large nodules were not found in any of patients with cytomegalovirus pneumonia. The presence of ground-glass opacity, reticulation, and bronchial wall thickening (all P > 0.05) were common in both groups. Conclusions: Analysis of consolidation, nodules, and halo signs may contribute to the differential diagnosis of pneumocystis pneumonia or cytomegalovirus pneumonia. However, some CT features considered typical in one or other diseases appear with similar frequency in both cohorts of AIDS patients. CT features are potentially useful for the differential diagnosis of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients.
Evaluation of maize lodging resistance based on the critical wind speed of stalk breaking during the late growth stage
Authors: Xue Jun , Ming Bo , Xie Ruizhi , Wang Keru , Hou Peng , Li Shaokun 
Published: October 2020

Abstract
Background: The accurate evaluation of the stalk-lodging resistance during the late stage of maize growth can provide a basis for the selection of cultivars, the evaluation of cultivation techniques, and timely mechanical grain harvesting. In this study, the critical wind speed of stalk breaking, plant morphology, stalk mechanical strength, and lodging rate were investigated in 10 maize cultivars to identify the parameters evaluate lodging resistance during the later growth stage of maize . Clarify the relationship with the stalk mechanical strength, critical wind speed of stalk breaking, and natural lodging rate in the field. Results: The results showed that, in the late growth stage, with increasing number of days after physiological maturity, (1) the stalk lodging rate gradually increased, (2) the stalk breaking force and rind penetration strength (RPS) of the third internode above the soil gradually decreased, and (3) the critical wind speed of stalk breaking increased first and then decreased, and was highest at about 16–24 days after physiological maturity. The position of stalk lodging mostly occured betwen second and fifth internodes. The torque at the base of maize plant increased as wind speed increased, and ther different of torque was excited among different maize cultivars under same wind speed. Furthermore, the stalk lodging rate was significantly negatively correlated with the critical wind speed of stalk breaking. Additionally, the critical wind speed of stalk breaking was significantly positively correlated with the stalk breaking force and the RPS. Conclusion: This indicates that the critical wind speed of stalk breaking is a superior way to determine the stalk lodging resistance. These results suggest that, in the late growth stage, the decrease in the stalk mechanical strength is an important reason for the decrease in the critical wind speed of stalk breaking and the increase in the lodging rate.
Inhibitory control training improves ADHD symptoms and externalizing behavior&nbsp;
Authors: Nejati Vahid , Fallah Fateme , Raskin Sarah 
Published: October 2020

Abstract
Background: The majority of cognitive and behavioral deficits in children with attention deficit- hyperactivity disorder (ADHD) originate from impaired inhibitory control. Methods: In the present study, thirty preschoolers with ADHD were recruited in a random clinical trial design in two equal control and intervention groups. The Color-Word Stroop test, Go/No- Go task, Swanson, Nolan, and Pelham Rating Scale, and Child Behavior Checklist were used for assessment at baseline, after intervention, and at one- month follow- up sessions. The program for attentive rehabilitation of inhibition and selective attention (PARISA) was used for intervention in 12-15 sessions. Results: The data demonstrate improvement in prepotent inhibition and interference control in the intervention group. Furthermore, the hyperactivity/ impulsivity symptoms were ameliorated and the externalizing behavioral problem were improved after intervention. Conclusion: Inhibitory control in preschoolers with ADHD is trainable and the benefit of training could be transferred to ADHD symptoms and externalizing behavior.Trial registration: IR.IAU.TMU.REC.1398.046.
Protocol for a systematic review on the experience of informal caregivers for people with a moderate to advanced dementia within a domestic home setting
Authors: James Charles , Walshe Catherine , Froggatt Katherine 
Published: October 2020

Abstract
BackgroundThe knowledge about the experience of informal caregivers who provide care to people with moderate to advanced dementia in a domestic home setting is limited. A consequence of long hours of caregiving in addition to dealing with normal challenges of daily living is their experience of a poor quality of life. Some of their experiences may be described in terms of a feeling of powerlessness to make changes during care provision. This feeling may also suggest an experience of moral distress. The aim of this systematic review is to synthesise qualitative evidence relating to these experiences.MethodsThis review adopts a narrative synthesis approach. A search will be conducted for studies written in English language in the bibliographic databases MEDLINE Complete, CINAHL, EMBASE, PsycINFO, Web of Science, and Academic Search Complete covering periods from 1984 to present. Included studies will be qualitative or mixed method designs. The search terms will be related to dementia and caregivers, and the process will be focused on dementia at the moderate to the advanced stages within the domestic home-setting. Reference lists of included papers will also be searched for additional relevant citations. Search terms and strategy will be checked by two independent reviewers. The identification of abstracts and full texts of studies will be done by the author, while the quality and the risk of bias will also be checked by the two independent reviewers.DiscussionPsychological distress is cited as an experience reported within informal caregiving. For the caregiver, it is associated with a negative impact on general health. To date, no synthesis exists on the specific experience of informal caregiving for people with moderate to advanced dementia within the domestic home setting. This review considers that variation of accounts contributes to how the informal caregivers’ general experience is explored in future research. This may enable gaps in current knowledge to be highlighted within the wider context of caregiving in the domestic home setting.Systematic review registrationThis review was registered and published online in the PROSPERO database of systematic reviews (www.crd.york.ac.uk/PROSPERO registration number: #CRD42020183649).
Induction chemotherapy for the individualised treatment of hypopharyngeal carcinoma with cervical oesophageal invasion: a retrospective cohort study
Authors: Huang Tian-qiao , Wang Ru , Fang Ju-gao , He Shi-zhi , Zhong Qi , Hou Li-zhen , Ma Hong-zhi , Chen Xiao-hong , Chen Xue-jun , Li Ping-dong , Feng Ling , Shi Qian , Lian Meng 
Published: October 2020

Abstract
Background: The aim of this study was to evaluate the potential of induction chemotherapy as an indicator of the management of advanced hypopharyngeal carcinoma with cervical oesophageal invasion. Methods: Sixty-eight patients admitted to our hospital between February 2003 and November 2016 with stage IVB hypopharyngeal carcinoma with cervical oesophageal invasion were retrospectively analysed. Patients were divided into two groups according to the treatment they selected following an explanation of the different treatments available. Patients in Group A received induction chemotherapy and had (1) complete/partial remission following chemotherapy and radiotherapy/concurrent chemoradiotherapy or (2) stable disease following chemotherapy and surgery. Patients in Group B underwent surgery followed by adjuvant radiotherapy/concurrent chemoradiotherapy. Survival analyses were performed using the Kaplan–Meier method, and differences between the groups were evaluated using the log-rank test. Laryngeal and oesophageal retention rates were compared using the cross-tabulation test. Results: The 3- and 5-year overall survival rates were 22.86% and 11.43% in Group A and 24.25% and 6.06% in Group B, respectively (all P > 0.05). The laryngeal and oesophageal retention rates were 40.0% and 74.3% in Group A and 0.0% and 27.3% in Group B, respectively (all P < 0.01). There was no statistically significant difference in the incidence of post-operative complications between the two groups (Group A: 8.6%, Group B: 12.1%; P > 0.05). Conclusions: Induction chemotherapy may be an appropriate first choice to ensure laryngeal and oesophageal preservation in the individualised treatment of advanced hypopharyngeal carcinoma with cervical oesophageal invasion.