bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational Analysis of Transverse Sonic Injection in Supersonic Crossflow Using RANS Models
Authors: Sharma Vatsalya , Eswaran Vinayak , Chakraborty Debasis 
Published: January 2020

AbstractTransverse injection at sonic speed from a rectangular slot into a supersonic crossflow is numerically explored with an indigenously developed parallel three-dimensional (3D) Reynold-averaged Navier–Stokes (RANS) solver for unstructured grids. The RANS models used for turbulence closure are the one-equation Spalart–Allmaras (SA) model and the two-equation shear stress transport (SST) model. For each model, the influence of compressibility corrections is assessed. Due to the presence of shock-turbulent boundary layer interaction (STBLI) in the flow, various STBLI corrections are assessed for both the models. Most of the simulations are two-dimensional (2D), but three-dimensional simulations are also performed to investigate the mismatch between the experimental dataset and the numerical results. The SA model is less sensitive to STBLI corrections, but some improvement in its prediction of the separation distance is found with the compressibility corrections. The SST model results are insensitive to the compressibility corrections, but the STBLI correction improves its results. Improved agreement with the experimental dataset is found when simulations are done in 3D, suggesting that the experiments were not so close to 2D as previously believed.
Optimization of Non-axisymmetric Endwall Contours for the Rotor of a Low Speed, 112-Stage Research Turbine With Unshrouded Blades—Optimization and Experimental Validation
Authors: Bergh Jonathan , Snedden Glen , Dunn Dwain 
Published: January 2020

Abstract
This paper presents the predicted, as well as final experimental results for the design of an automatically optimized non-axisymmetric endwall and as such, attempts to close the loop between design and practice, providing additional information to other groups involved in the design of endwall contours. The contours designed in this investigation were manufactured using the direct laser sintering rapid prototyping method and installed and tested in the low-speed, 112-stage turbine at the CSIR’s test turbine facility (TTF) in Pretoria, South Africa. Steady-state 5-hole pressure probe traverses were used to characterize the performance and flow profiles upstream, immediately downstream and in a quasi-“mixed-out” sense downstream of the rotor. In addition to the datum (annular) case, both the computed as well as experimental results were compared to the corresponding results generated for a “generically” contoured rotor which was originally designed for a linear cascade test case, but one which used the same blade profile to the current case. The results show that in general both sets of contours performed well, although the added emphasis on flow correction for the contours produced in this investigation resulted in slightly worse performance in terms of loss at the rotor exit (X3) but greatly improved performance in terms of the efficiency and flow angles at the “mixed-out” (X4) measurement plane.
Porosity-Driven Approaches to Model Fouling Effects on Flow Field
Authors: Casari Nicola , Suman Alessio , Pinelli Michele 
Published: January 2020

AbstractAir contamination by solid particles represents a real hazard for compressors for both heavy-duty and aeropropulsion gas turbines. Particles impacting the inner surfaces of the machine can stick to such surfaces or erode them. The presence of deposits entails a reduction in performance, in a phenomenon commonly referred to as fouling. As the severity of the problem increases, the performance reduction can become so big to demand engine shut down and offline washing. Numerical modeling is one of the techniques employed for tackling the fouling problem. In this work, an innovative procedure is proposed to evaluate the losses and the variation in the fluid flow due to the deposits. Specifically, as the deposit grows, it is assumed that it forms a porous medium attached to the wall. The porosity of this zone (related to the packing of the particles and to the number of particles that sticks to that portion of the wall) is responsible for the deposition-induced losses. Different approaches to compute such losses are proposed and discussed. By using this methodology, the two main effects of fouling (variation in roughness and in shape of the airfoil) can be easily included in a comprehensive analysis of the variation of the performance of the compressor over time. Furthermore, this approach overcomes the difficulties that may arise by using a mesh morphing technique. The computational grid is not modified, and thus, its quality is retained, without remeshing requirements, even for large deposits.
Comparison of Thin Film Heat Flux Gauge Technologies Emphasizing Continuous-Duration Operation
Authors: Siroka Shawn , Berdanier Reid A. , Thole Karen A. , Chana Kam , Haldeman Charles W. , Anthony Richard J. 
Published: January 2020

Abstract
Thin-film heat flux gauges (HFGs) have been used for decades to measure surface temperatures and heat flux in test turbines with the majority being used in facilities that are short-duration. These gauges are typically composed of two resistive temperature devices deposited on opposing sides of a dielectric. However, because these sensors have been traditionally applied for measurements in transient-type facilities, the challenges facing adaptation of this technology for a steady facility warrant investigation. These challenges are highlighted, and the solutions are presented throughout the paper. This paper describes the nanofabrication process for heat flux gauges and a new calibration method to address the potential deterioration of gauges over long runtimes in continuous-duration facilities. Because the primary uncertainty of these sensors arises from the ambiguity of the thermal properties, the emphasis is placed on the property determination. Also, this paper presents a discussion on the use of impulse response theory to process the data showing the feasibility of the method for steady-duration facilities after an initial settling time. The latter portion of the paper focuses on comparing well-established heat flux gauges developed for short-duration turbine test facilities to recently developed gauges fabricated using modern nanofabrication techniques for a continuous turbine test facility. The gauges were compared using the test case of an impinging jet over a range of Reynolds numbers. The comparison between the PSU gauge and the reference device indicated agreement within 14%, and similar results were achieved through comparison with established sensors from partner institutions.
Pulverized quartz clasts in gouge of the Alhama de Murcia fault (Spain): Evidence for coseismic clast pulverization in a matrix deformed by frictional sliding
Authors: Rodríguez-Escudero Emilio , Martínez-Díaz José J. , Giner-Robles Jorge L. , Tsige Meaza , Cuevas-Rodríguez Jaime 
Published: January 2020

AbstractThe fault gouge of the Alhama de Murcia fault (southeast Spain) shows a texture that resembles a mylonite, including a prominent foliation, S-C fabric, and isoclinal folds. It also embeds a large number of isolated pulverized quartz clasts (PQCs). Structural analysis indicates that the gouge fabric was mainly developed by slow frictional sliding along phyllosilicate-lined Riedel shear bands during continued shearing. In contrast, the PQCs show tensile fracture network features that are typically reported in seismically pulverized rocks found along seismogenic faults. This suggests that quartz-clast pulverization was due to a transient dilatational mechanism rather than shearing. We propose that the PQCs are the result of a rapid confined stress drop related to transient tensile stresses during coseismic ruptures that interrupt creep faulting along the gouge zone. The present study suggests that there is probably a large amount of evidence for paleoseismicity in fault rocks that is currently overlooked.
Nutritional rickets under 16 years: UK surveillance results
Authors: Julies Priscilla , Lynn Richard M , Pall Karina , Leoni Marina , Calder Alistair , Mughal Zulf , Shaw Nick , McDonnell Ciara , McDevitt Helen , Blair Mitch 
Published: January 2020

ObjectiveThe UK national incidence of nutritional rickets is unknown. We aimed to describe the incidence, presentation and clinical management of children under 16 years with nutritional rickets in the UK presenting to secondary care.MethodsProspective data were collected monthly between March 2015 and March 2017 from 3500 consultant paediatricians using British Paediatric Surveillance Unit methodology. Clinicians completed online clinical questionnaires for cases fitting the surveillance case definition.Results125 cases met the case definition, an annual incidence of 0.48 (95% CI 0.37 to 0.62) per 100 000 children under 16 years. 116 children were under 5 years (annual incidence of 1.39 (95% CI 1.05 to 1.81) per 100 000. Boys (70%) were significantly more affected than girls (30%) (OR 2.17, 95% CI 1.25 to 3.78). The majority were of Black (43%) or South Asian (38%) ethnicity. 77.6% of children were not taking vitamin D supplements despite being eligible. Complications included delayed gross motor development (26.4%), fractures (9.6%), hypocalcaemic seizures (8%) and dilated cardiomyopathy (3%). Two children died (1.6%). In eight cases, rickets was confirmed radiologically and biochemically [raised serum alkaline phosphatase (ALP) and parathyroid hormone (PTH) levels ] but were excluded from the incidence analysis for not meeting the case definition of 25-hydroxyvitamin D of <25 nmol/L.ConclusionThe incidence of nutritional rickets in the UK is lower than expected. Serious complications and unexpected deaths, particularly in Black and South Asian children under 5 years, occurred. Both vitamin D deficiency and dietary calcium deficiency are role players in pathogenesis. Uptake of vitamin D supplementation remains low.
Epidemiology of invasive ocular surface squamous neoplasia in Canada during 1992–2010
Authors: Darwich Rami , Ghazawi Feras M , Le Michelle , Rahme Elham , Alghazawi Nebras , Zubarev Andrei , Moreau Linda , Sasseville Denis , Burnier Miguel N , Litvinov Ivan V 
Published: January 2020

BackgroundOcular surface squamous neoplasia (OSSN) is the most common non-pigmented ocular surface malignancy. It is classified as invasive OSNN (IOSSN) when the underlying stroma are infiltrated by dysplastic squamous epithelial cells through the basement membrane. Here, we present the descriptive epidemiology and geographical distribution of IOSSN in Canada.MethodsWe determined the incidence and geographical distribution of IOSSN cases diagnosed between 1992 and 2010 using two independent population-based cancer registries: the Canadian Cancer Registry and Le Registre Québécois du Cancer.ResultsThe mean annual age-standardised incidence rate (WHO 2000–2025) of IOSSN for 1992–2010 was 0.45 cases per million individuals per year with an average annual percent increase in incidence of 4.5%. IOSSN localisation to the conjunctiva was documented in at least 57% of the reported cases. IOSSN exhibited a male predilection ratio of 3.3:1.0 with a mean age at diagnosis of 69 years. Incidence rates of IOSSN across Canadian provinces and cities showed no significant differences from the crude national average.ConclusionsOur results, particularly concerning IOSSN patient age and male predilection, corroborate with data reported from the USA. Additional studies are needed to determine whether the observed increase in incidence rate over the study period (1992–2010) is significant.
Diagnostic performance of modern imaging instruments in glaucoma screening
Authors: Karvonen Elina , Stoor Katri , Luodonpää Marja , Hägg Pasi , Lintonen Timo , Liinamaa Johanna , Tuulonen Anja , Saarela Ville 
Published: January 2020

AimTo evaluate the applicability of imaging devices (spectral-domain optical coherence tomography (Cirrus SD-OCT), scanning laser polarimetry (GDx) and scanning laser ophthalmoscopy (Heidelberg Retinal Tomograph, HRT3)) for glaucoma screening in a middle-aged unselected population.MethodsParticipants of the population-based Northern Finland Birth Cohort Eye Study, aged 45 to 49 years, underwent a comprehensive eye examination including modern imaging with five methods (retinal nerve fibre layer (RNFL) and macular ganglion cell layer +inner plexiform layer (GCIPL) analysis and their combination with SD-OCT, GDx and HRT). The performance of the automated classification of the imaging devices was assessed using a clinical glaucoma diagnosis as reference, that is, the ‘2 out of 3’ rule based on the evaluation of optic nerve head and RNFL photographs and visual fields.ResultsWe examined 6060 eyes of 3039 subjects; in the clinical evaluation, glaucomatous damage was found in 33 subjects (1.1%) in 43 eyes. The following sensitivities were obtained; RNFL analysis (53%), GCIPL analysis (50%), OCT combination analysis (61%), GDx (56%) and HRT (31%) with corresponding specificities of 95%, 92%, 90%, 88% and 96%. The area under the curve values were 0.76, 0.73, 0.75, 0.75 and 0.73, respectively. Post-test probabilities of glaucoma after positive imaging finding with each of these methods in this unselected population were 11%, 7%, 6%, 5% and 7%, respectively.ConclusionScreening capabilities of the OCT, GDx and HRT were rather similar. The accuracy of all evaluated parameters was only moderate and thus screening with these parameters alone is not reliable.
System accuracy evaluation of 18 CE-marked current-generation blood glucose monitoring systems based on EN ISO 15197:2015
Authors: Pleus Stefan , Baumstark Annette , Jendrike Nina , Mende Jochen , Link Manuela , Zschornack Eva , Haug Cornelia , Freckmann Guido 
Published: January 2020

ObjectiveAccuracy of 18 current-generation blood glucose monitoring systems (BGMS) available in Europe was evaluated applying criteria adapted from EN ISO 15197:2015 with one reagent system lot. BGMS were selected based on market research data.Research design and methodsThe BGMS ABRA, Accu-Chek Guide, AURUM, CareSens Dual, CERA-CHEK 1CODE, ContourNext One, eBsensor, FreeStyle Freedom Lite, GL50 evo, GlucoCheck GOLD, GlucoMen areo 2K, GluNEO, MyStar DoseCoach, OneTouch Verio Flex, Pic GlucoTest, Rightest GM700S, TRUEyou, and WaveSense JAZZ Wireless were tested using capillary blood from 100 different subjects and assessing the percentage of results within ±15 mg/dL (0.83 mmol/L) or 15% of comparison method results for BG concentrations below or above 100 mg/dL (5.55 mmol/L), respectively. In addition, the minimal deviation from comparison method results within which ≥95% of results of the respective BGMS were found was calculated.ResultsIn total, 14 BGMS had ≥95% of results within ±15 mg/dL (0.83 mmol/L) or ±15% and 3 BGMS had ≥95% of results within ±10 mg/dL (0.55 mmol/L) or ±10% of the results obtained with the comparison method. The smallest deviation from comparison method results within which ≥95% of results were found was ±7.7 mg/dL (0.43 mmol/L) or ±7.7%; the highest deviation was ±19.7 mg/dL (1.09 mmol/L) or ±19.7%.ConclusionsThis accuracy evaluation shows that not all CE-labeled BGMS fulfill accuracy requirements of ISO 15197 reliably and that there is considerable variation even among BGMS fulfilling these criteria. This safety-related information should be taken into account by patients and healthcare professionals when making therapy decisions.Trial registration numberNCT03737188.
Enhanced recovery following hip and knee arthroplasty: a systematic review of cost-effectiveness evidence
Authors: Pritchard Mark G , Murphy Jacqueline , Cheng Lok , Janarthanan Roshni , Judge Andrew , Leal Jose 
Published: January 2020

AbstractObjectivesTo assess cost-effectiveness of enhanced recovery pathways following total hip and knee arthroplasties. Secondary objectives were to report on quality of studies and identify research gaps for future work.DesignSystematic review of cost–utility analyses.Data sourcesOvid MEDLINE, Embase, the National Health Service Economic Evaluations Database and EconLit, January 2000 to August 2019.Eligibility criteriaEnglish-language peer-reviewed cost–utility analyses of enhanced recovery pathways, or components of one, compared with usual care, in patients having total hip or knee arthroplasties for osteoarthritis.Data extraction and synthesisData extracted by three reviewers with disagreements resolved by a fourth. Study quality assessed using the Consensus on Health Economic Criteria list, the International Society for Pharmacoeconomics and Outcomes Research and Assessment of the Validation Status of Health-Economic decision models tools; for trial-based studies the Cochrane Collaboration’s tool to assess risk of bias. No quantitative synthesis was undertaken.ResultsWe identified 17 studies: five trial-based and 12 model-based studies. Two analyses evaluated entire enhanced recovery pathways and reported them to be cost-effective compared with usual care. Ten pathway components were more effective and cost-saving compared with usual care, three were cost-effective, and two were not cost-effective. We had concerns around risk of bias for all included studies, particularly regarding the short time horizon of the trials and lack of reporting of model validation.ConclusionsConsistent results supported enhanced recovery pathways as a whole, prophylactic systemic antibiotics, antibiotic-impregnated cement and conventional ventilation for infection prevention. No other interventions were subject of more than one study. We found ample scope for future cost-effectiveness studies, particularly analyses of entire recovery pathways and comparison of incremental changes within pathways. A key limitation is that standard practices have changed over the period covered by the included studies.PROSPERO registration numberCRD42017059473.
Point-of-care blood tests during home visits by out-of-hours primary care clinicians; a mixed methods evaluation of a service improvement
Authors: Hayward Gail , Dixon Sharon , Garland Sophie , Glogowska Margaret , Hunt Helen , Lasserson Daniel 
Published: January 2020

ObjectivesWe aimed to evaluate test usage and patient and clinician experience following the introduction of point-of-care (POC) blood tests into a primary care out-of-hours service.DesignA mixed methods service evaluation comprising quantitative records of the clinical contexts of tests taken and qualitative interviews with clinicians. Research permissions and governance were obtained for patient interviews.SettingOut-of-hours primary care.ParticipantsAll patients requiring home visits from the service during the implementation period.InterventionsThe i-STAT POC blood test platform was introduced to two bases providing home visits for a period of 8 months. Venous blood samples were used and two cartridges were available. The CHEM8 cartridge measures sodium, potassium, chloride, total carbon dioxide (TCO2), anion gap, ionised calcium, glucose, urea, creatinine, haematocrit and haemoglobin. The CG4 cartridge measures lactate, pH, PaO2 and PCO2, TCO2, bicarbonate, base excess and oxygen saturation.Primary and secondary outcome measuresThe proportion of home visits where tests were taken, the clinical contexts of those tests, the extent to which clinicians felt the tests had influenced their decisions, time taken to perform the test and problems encountered. Clinician and patient experiences of using POC tests.Resultsi-STAT POC tests were infrequently used, with successful tests taken at just 47 contacts over 8 months of implementation. The patients interviewed felt that testing had been beneficial for their care. Clinician interviews suggested barriers to POC tests, including practical challenges, concerns about time, doubt over whether they would improve clinical decision making and concern about increased medicolegal risk. Suggestions for improving adoption included sharing learning, adopting a whole team approach and developing protocols for usage.ConclusionsPOC tests were not successfully adopted by an out-of-hours home visiting service in Oxfordshire. While some clinicians felt they could not add value, in other cases they resulted in improved patient experience. Adoption could be promoted by improving technical, team and education factors.
Improving the quality of life of patients with breast cancer-related lymphoedema by lymphaticovenous anastomosis (LVA): study protocol of a multicentre randomised controlled trial
Authors: Wolfs Joost , Beugels Jop , Kimman Merel , Piatkowski de Grzymala Andrzej A , Heuts Esther , Keuter Xavier , Tielemans Hanneke , Ulrich Dietmar , van der Hulst R , Qiu Shan Shan 
Published: January 2020

IntroductionEarly breast cancer detection and advancements in treatment options have resulted in an increase of breast cancer survivors. An increasing number of women are living with the long-term effects of breast cancer treatment, making the quality of survivorship an increasingly important goal. Breast cancer-related lymphoedema (BCRL) is one of the most underestimated complications of breast cancer treatment with a reported incidence of 20%. A microsurgical technique called lymphaticovenous anastomosis (LVA) might be a promising treatment modality for patients with BCRL. The main objective is to assess whether LVA is more effective than the current standard therapy (conservative treatment) in terms of improvement in quality of life and weather it is cost-effective.Methods and analysisA multicentre, randomised controlled trial, carried out in two academic and two community hospitals in the Netherlands. The study population includes 120 women over the age of 18 who have undergone treatment for breast cancer including axillary treatment (sentinel lymph node biopsy or axillary lymph node dissection) and/or axillary radiotherapy, presenting with an early stage lymphoedema of the arm, viable lymphatic vessels and received at least 3 months conservative treatment. Sixty participants will undergo the LVA operation and the other sixty will continue their regular conservative treatment, both with a follow-up of 24 months. The primary outcome is the health-related quality of life. Secondary outcomes are societal costs, quality adjusted life years, cost-effectiveness ratio, discontinuation rate of conservative treatment and excess limb volume.Ethics and disseminationThe study was approved by the Ethics Committee of Maastricht University Medical Center (METC) on 19 December 2018 (NL67059.068.18). The results of this study will be disseminated in presentations at academic conferences, publications in peer-reviewed journals and other news media.Trial registration numberNCT02790021; Pre-results.
Liga de pediatria comunitária – o futuro médico trabalhando em equipe para promover a saúde de crianças carentes
Authors: Yamamoto Renato Minoru , Cianciarullo Andréa , Serra Henrique André , Vicente João Pedro , Primo Ednéia 
Published: January 2020

A Seção de Assitência Comunitária do Instituto da Criança do Hospital das Clínicas da FMUSP, desde 1996, desenvolve projeto de saúde comunitária numa fração na área de abrangência do Centro de Saúde Escola “Prof. Samuel B. Pessoa”, Favela Vila Nova Alba. A Liga de Pediatria Comunitária iniciou suas atividades neste local em 1998 com o objetivo de iniciar o alunbo da Graduação na compreensão no processo saúde-escola valorizando o papel das famílias e das condições reais de vida da criança sobre sua saúde, desenvolvendo atividades voltadas para a extensão de serviços a esta comunidade. Apresentamos as atividades desenvolvidas e resultados obtidos no período de 1999 a 2004.