bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ankle ligament reconstruction-return to sport after injury (ALR-RSI) is a valid and reproducible scale to quantify psychological readiness before returning to sport after ankle ligament reconstruction
Authors: Sigonney François , Lopes Ronny , Bouché Pierre-Alban , Kierszbaum Elliott , Moslemi Aymane , Anract Philippe , Stein Alexandra , Hardy Alexandre 
Published: April 2020

AbstractPurposeChronic ankle instability is the main complication of ankle sprains and requires surgery if non-operative treatment fails. The goal of this study was to validate a tool to quantify psychological readiness to return to sport after ankle ligament reconstruction.MethodsThe form was designed like the anterior cruciate ligament-return to sport after injury scale and “Knee” was replaced by the term “ankle”. The ankle ligament reconstruction-return to sport after injury (ALR-RSI) scale was filled by patients who underwent ankle ligament reconstruction and were active in sports. The scale was then validated according to the international COSMIN methodology. The AOFAS and Karlsson scores were used as reference questionnaires.ResultsFifty-seven patients (59 ankles) were included, 27 women. The ALR-RSI scale was strongly correlated with the Karlsson score (r = 0.79 [0.66–0.87]) and the AOFAS score (r = 0.8 [0.66–0.87]). A highly significant difference was found in the ALR-RSI between the subgroup of 50 patients who returned to playing sport and the seven who did not: 68.8 (56.5–86.5) vs 45.0 (31.3–55.8), respectively,p = 0.02. The internal consistency of the scale was high (α = 0.96). Reproducibility of the test–retest was excellent (ρ = 0.92; 95% CI [0.86–0.96]).ConclusionThe ALR-RSI is a valid, reproducible scale that identifies patients who are ready to return to the same sport after ankle ligament reconstruction. This scale may help to identify athletes who will find sport resumption difficult.Level of evidenceIII.
Pollution Sources Reconstruction Based on the Topological Derivative Method
Authors: Fernandez L. , Novotny A. A. , Prakash R. , Sokołowski J. 
Published: April 2020

AbstractThe topological derivative method is used to solve a pollution sources reconstruction problem governed by a steady-state convection-diffusion equation. To be more precise, we are dealing with a shape optimization problem which consists of reconstruction of a set of pollution sources in a fluid medium by measuring the concentration of the pollutants within some subregion of the reference domain. The shape functional measuring the misfit between the known data and solution of the state equation is minimized with respect to a set of ball-shaped geometrical subdomains representing the pollution sources. The necessary conditions for optimality are derived with the help of the topological derivative method which consists in expanding the shape functional asymptotically and then truncate it up to the second order term. The resulting expression is trivially minimized with respect to the parameters under consideration which leads to a noniterative second-order reconstruction algorithm. Two different cases are considered. Firstly, when the velocity of the leakages is given and we reconstruct the support of the unknown sources, including their locations and sizes. In the second case, we consider the size of the pollution sources to be known and find out the mean velocity of the leakages and their locations. Numerical examples are presented showing the capability of the proposed algorithm in reconstructing multiple pollution sources in both cases.
The influence of circulation weather types on the exposure of the biosphere to atmospheric electric fields
Authors: Kourtidis K. , Szabóné André K. , Karagioras A. , Nita I.-A. , Sátori G. , Bór J. , Kastelis N. 
Published: April 2020

AbstractWe present an analysis of the impact of circulation weather types (CT) on a factor that might influence biological systems and the human condition, the electric state of the atmosphere. We present results on the influence of CT to the magnitude, the direction (positive or negative), the fluctuation magnitude, and the short-term peaks of the atmospheric electric field (potential gradient, PG), using data from a station in Greece. CTs with high vorticity centers over Greece are associated with high positive and negative excursions of the PG, higher PG variability, and rain events. CTs with thinner 850–500 hPa layer are associated with higher daily mean values of fair-weather PG. We also examine the influence of CT on the frequency and amplitude of the naturally occurring extremely low-frequency electric field fluctuations known as Schumann resonances (SR) using data from a station in Hungary. The first and second mode SR frequencies are increased during CTs associated with higher 500 hPa geopotential heights and higher 850–500 hPa layer thickness. This hints to a lower-upper atmosphere coupling. So, CTs not only influence the general temperature and humidity conditions to which the biosphere is exposed, but they also affect its exposure to atmospheric electric fields.
Isolation and characterization of 2-butoxyethanol degrading bacterial strains
Authors: Woiski Christine , Dobslaw Daniel , Engesser Karl-Heinrich 
Published: April 2020

AbstractA total of 11 bacterial strains capable of completely degrading 2-butoxyethanol (2-BE) were isolated from forest soil, a biotrickling filter, a bioscrubber, and activated sludge, and identified by 16S rRNA gene sequence analysis. Eight of these strains belong to the genus Pseudomonas; the remaining three strains are Hydrogenophaga pseudoflava BOE3, Gordonia terrae BOE5, and Cupriavidus oxalaticus BOE300. In addition to 2-BE, all isolated strains were able to grow on 2-ethoxyethanol and 2-propoxyethanol, ethanol, n-hexanol, ethyl acetate, 2-butoxyacetic acid (2-BAA), glyoxylic acid, and n-butanol. Apart from the only gram-positive strain isolated, BOE5, none of the strains were able to grow on the nonpolar ethers diethyl ether, di-n-butyl ether, n-butyl vinyl ether, and dibenzyl ether, as well as on 1-butoxy-2-propanol. Strains H. pseudoflava BOE3 and two of the isolated pseudomonads, Pseudomonas putida BOE100 and P. vancouverensis BOE200, were studied in more detail. The maximum growth rates of strains BOE3, BOE100, and BOE200 at 30 °C were 0.204 h−1 at 4 mM, 0.645 h−1 at 5 mM, and 0.395 h−1 at 6 mM 2-BE, respectively. 2-BAA, n-butanol, and butanoic acid were detected as potential metabolites during the degradation of 2-BE. These findings indicate that the degradation of 2-BE by the isolated gram-negative strains proceeds via oxidation to 2-BAA with subsequent cleavage of the ether bond yielding glyoxylate and n-butanol. Since Gordonia terrae BOE5 was the only strain able to degrade nonpolar ethers like diethyl ether, the degradation pathway of 2-BE may be different for this strain.
Rapid lipid bilayer membrane formation on Parylene coated apertures to perform ion channel analyses
Authors: Ahmed Tanzir , van den Driesche Sander , Bafna Jayesh Arun , Oellers Martin , Hemmler Roland , Gall Karsten , Wagner Richard , Winterhalter Mathias , Vellekoop Michael J. 
Published: April 2020

AbstractWe present a chip design allowing rapid and robust lipid bilayer (LBL) membrane formation using a Parylene coated thin silicon nitride aperture. After bilayer formation, single membrane channels can be reconstituted and characterized by electrophysiology. The ability for robust reconstitution will allow parallelization and enhanced screening of small molecule drugs acting on or permeating across the membrane channel. The aperture was realized on a microfabricated silicon nitride membrane by using standard clean-room fabrication processes. To ensure the lipid bilayer formation, the nitride membrane was coated with a hydrophobic and biocompatible Parylene layer. We tested both Parylene-C and Parylene-AF4. The contact angle measurements on both Parylene types showed very good hydrophobic properties and affinity to lipids. No precoating of the Parylene with an organic solvent is needed to make the aperture lipophilic, in contradiction to Teflon membranes. The chips can be easily placed in an array utilizing a 3D printed platform. Experiments show repetitive LBL formation and destruction (more than 6 times) within a very short time (few seconds). Through measurements we have established that the LBL layers are very thin. This allows the investigation of the fusion process of membrane proteins i.e. outer membrane protein (OmpF) in the LBL within a few minutes.
Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
Authors: Gómez-Acebo Inés , Dierssen-Sotos Trinidad , Palazuelos-Calderón Camilo , Pérez-Gómez Beatriz , Amiano Pilar , Guevara Marcela , Molina Antonio J. , Domingo Laia , Fernández-Ortiz María , Moreno Victor , Alguacil Juan , Fernández-Tardón Guillermo , Ibáñez Josefa , Marcos-Gragera Rafael , Diaz-Santos Marian , Alonso M. Henar , Alonso-Molero Jessica , Castaño-Vinyals Gemma , Palomo Andrés García , Ardanaz Eva , Molinuevo Amaia , Aragonés Nuria , Kogevinas Manolis , Pollán Marina , Llorca Javier 
Published: April 2020

Abstract
Purpose
The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score.

Methods
The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors.

Results
Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively.

Conclusion
Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased
Disease mapping of early- and late-stage cancer to monitor inequalities in early detection: a study of cutaneous malignant melanoma
Authors: Strömberg Ulf , Parkes Brandon L. , Holmén Anders , Peterson Stefan , Holmberg Erik , Baigi Amir , Piel Frédéric B. 
Published: April 2020

AbstractWe consider disease mapping of early- and late-stage cancer, in order to identify and monitor inequalities in early detection. Our method is demonstrated by mapping cancer incidence at high geographical resolution using data on 10,302 cutaneous malignant melanoma (CMM) cases within the 3.7 million population of South-West Sweden. The cases were geocoded into small-areas, each with a population size between 600 and 2600 and accessible socio-demographic data. Using the disease mapping application Rapid Inquiry Facility (RIF) 4.0, we produced regional maps to visualise spatial variations in stage I, II and III–IV CMM incidences, complemented by local maps to explore the variations within two urban areas. Pronounced spatial disparities in stage I CMM incidence were revealed by the regional and local maps. Stage I CMM incidence was markedly higher in wealthier small-areas, in particular within each urban area. A twofold higher stage I incidence was observed, on average, in the wealthiest small-areas (upper quintile) than in the poorest small-areas (lower quintile). We identified in the regional map of stage III–IV CMM two clusters of higher or lower than expected late-stage incidences which were quite distinct from those identified for stage I. In conclusion, our analysis of CMM incidences supported the use of this method of cancer stage incidence mapping for revealing geographical and socio-demographic disparities in cancer detection.
Sanitary condition and its microbiological quality of improved water sources in the Southern Region of Ethiopia
Authors: Alemayehu Tsigereda Assefa , Weldetinsae Abel , Dinssa Daniel Abera , Derra Firehiwot Abera , Bedada Tesfaye Legese , Asefa Yosef Beyene , Mengesha Sisay Derso , Alemu Zinabu Assefa , Serte Melaku Gizaw , Teklu Kirubel Tesfaye , Woldegabriel Mesay Getachew , Kenea Moa Abate , van den Berg Harold , de Roda Husman Ana Maria 
Published: April 2020

AbstractIn the Southern Nations, Nationalities, and Peoples’ Region of Ethiopia, improved water is the main source of water for household purposes. Access to improved water closer to their homes benefits the community in many ways. It improves their health status, saves their time and energy, and improves their productivity in jobs and education they are engaged in. However, due to natural and human activities, improved water sources do not always deliver good quality of water. It can be contaminated by different pathogenic microorganisms and chemicals. The result indicated that 44.7% and 50.9% of the samples were contaminated with Escherichia coli and enterococci respectively, and from the sanitary condition survey, 57.6% of the water sources exhibited from intermediate- to very high-risk level. And the risk priority matrix identifies 95 (27.9%) samples with high risk and 54 (15.9%) of the samples with very high risk. The main risks identified at those unsafe water sources were that the drainage canals were blocked with mud, grass, leaves, and stones; animals drinking the overflow water and grazing in the proximity of water sources and feces such as cow dung were observed; inadequate protection of water sources such as absence of fences and diversion ditches; and stagnant water near the source. The study conducted in the Southern Nations, Nationalities, and Peoples’ Region has clearly indicated that people may be at risk of being exposed to pathogens in half of the improved water sources when used for drinking based on the microbial indicator data or the sanitary inspection risk score. Though no correlation resulted from water quality and sanitary condition of sources, the risk priority matrix did enable prioritization of 54 very high-risk-level water sources for urgent targeted interventions from a total of 340 improved drinking water sources. From this, targeted interventions, improving water management practices, identifying and implementing effective water treatment options, providing sustainable energy sources for the supply of continuous water, and implementing climate resilience water safety planning, are recommended.
Development of the Observation Schedule for Children with Autism–Anxiety, Behaviour and Parenting (OSCA–ABP): A New Measure of Child and Parenting Behavior for Use with Young Autistic Children
Authors: Palmer Melanie , Paris Perez Juan , Tarver Joanne , Cawthorne Thomas , Frayne Margot , Webb Sophie , Baker Elena , Yorke Isabel , Hay Dale , Slonims Vicky , Pickles Andrew , Simonoff Emily , Scott Stephen , Charman Tony 
Published: April 2020

AbstractCo-occurring emotional and behavioral problems (EBPs) frequently exist in young autistic children. There is evidence based on parental report that parenting interventions reduce child EBPs. More objective measures of child EBPs should supplement parent reported outcomes in trials. We describe the development of a new measure of child and parenting behavior, the Observation Schedule for Children with Autism–Anxiety, Behaviour and Parenting (OSCA–ABP). Participants were 83 parents/carers and their 4–8-year-old autistic children. The measure demonstrated good variance and potential sensitivity to change. Child and parenting behavior were reliably coded among verbal and minimally verbal children. Associations between reports from other informants and observed behavior showed the measure had sufficient convergent validity. The measure has promise to contribute to research and clinical practice in autism mental health beyond objective measurement in trials.
Adenosine usage during AF ablation in Europe and selected long-term findings from the ESC-EHRA EORP Atrial Fibrillation Ablation Long-Term registry
Authors:   on behalf of the ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry investigators, van Rosmalen Frank , Delhaas Tammo , Dagres Nikolaos , Arbelo Elena , Blomström-Lundqvist Carina , Crijns Harry J. G. M. , Da Costa Antoine , Pytkowski Mariusz , Sharikov Nikita , Laroche Cécile , Tavazzi Luigi , Brugada Joseph , Pison Laurent 
Published: April 2020

Abstract
Background
Adenosine can be used to reveal dormant pulmonary vein (PV) conduction after PV isolation (PVI). This study presents a subanalysis of real-world 1-year follow-up data from the ESC-EHRA EORP Atrial Fibrillation (AF) Ablation Long-Term registry to analyze the usage of adenosine during PVI treatment in terms of rhythm outcome and safety.

Methods
The registry consists of 104 participating centers in 27 countries within the European Society of Cardiology. The registry data was split into an adenosine group (AG) and no-adenosine group (NAG). Procedure characteristics and patient outcome were compared.

Results
Adenosine was administered in 10.8% of the 3591 PVI patients included in the registry. Spain, the Netherlands, and Italy included the majority of adenosine cases (48.8%). Adenosine was applied more often in combination with open irrigation radiofrequency (RF) energy (74.7%) and less often in combination with nonirrigated RF energy (1.6%). After 1 year, a higher percentage of the AG was free from AF compared with the NAG (68.9% vs 59.1%, p < 0.001). Adenosine was associated with better rhythm outcome in RF ablation procedures, but not in cryo-ablation procedures (freedom from AF: RF: AG: 70.9%, NAG: 58.1%, p < 0.001, cryo: AG: 63.9%, NAG: 63.8%, p = 0.991).

Conclusions
The use of adenosine was associated with a better rhythm outcome after 1 year follow-up and seems more useful in patients treated with RF energy compared with patients treated with cryo energy. Given the improved rhythm outcome at 1-year follow-up, it seems reasonable to encourage the use of adenosine during RF AF ablation.
Experimental study of the Al–Cu–Zn ternary phase diagram
Authors: Zobac Ondrej , Kroupa Ales , Richter Klaus W. 
Published: April 2020

AbstractThe phase diagram of the Al–Cu–Zn ternary system was re-investigated experimentally. The current study was designed to contribute to a better description of those parts of the phase diagram, which are disputed in the current scientific literature. Mutual relations in the family of ternary intermetallic phases τ with cubic, rhombohedral and modulated structure at temperatures 400 °C and 550 °C were described. The phase relation between the γ and γ′ phases was studied at different temperatures. A two-phase field between γ and γ′ was observed below 400 °C, while the transition appears to be second order at higher temperatures. A vertical section between γ and γ′ phases in Cu–Zn and Al–Cu and four isothermal sections at 400 °C, 550 °C, 700 °C and 820 °C, respectively, were constructed.
Renormalizing the Kardar–Parisi–Zhang Equation in $$d\ge 3$$ in Weak Disorder
Authors: Comets Francis , Cosco Clément , Mukherjee Chiranjib 
Published: April 2020

AbstractWe study Kardar–Parisi–Zhang equation in spatial dimension 3 or larger driven by a Gaussian space–time white noise with a small convolution in space. When the noise intensity is small, it is known that the solutions converge to a random limit as the smoothing parameter is turned off. We identify this limit, in the case of general initial conditions ranging from flat to droplet. We provide strong approximations of the solution which obey exactly the limit law. We prove that this limit has sub-Gaussian lower tails, implying existence of all negative (and positive) moments.
The Co-development and Feasibility-Testing of an Innovative Digital Animation Intervention (DAISI) to Reduce the Risk of Maternal Sepsis in the Postnatal Period
Authors: Haith-Cooper Melanie , Stacey Tomasina , Bailey Fran , Broadhead-Croft Sarah 
Published: April 2020

Abstract
Introduction
Sepsis is one of the most common causes of mortality in postnatal women globally and many other women who develop sepsis are left with severe morbidity. Women’s knowledge of postnatal sepsis and how it can be prevented by simple changes to behaviour is lacking.

Methods
This paper describes the co-development and feasibility testing of a digital animation intervention called DAISI (digital animation in service improvement). This DAISI is designed to enhance postnatal women’s awareness of sepsis and how to reduce their risk of developing the condition. We co-designed the digital animation over a six-month period underpinned by theory, best evidence and key stakeholders, translated it into Urdu then assessed its use, firstly in a focus group with women from different Black, Asian and Minority Ethnic (BAME) groups and secondly with 15 clinical midwives and 15 women (including BAME women). Following exposure to the intervention, midwives completed a questionnaire developed from the COM-B behaviour change model and women participated in individual and focus group interviews using similar questions.

Results
The animation was considered acceptable, culturally sensitive and simple to implement and follow.

Discussion
DAISI appears to be an innovative solution for use in maternity care to address difficulties with the postnatal hospital discharge process. We could find no evidence of digital animation being used in this context and recommend a study to test it in practice prior to adopting its use more widely. If effective, the DAISI principle could be used in other maternity contexts and other areas of the NHS to communicate health promotion information.
Quality of life in women with endometriosis: a cross-sectional survey
Authors: Bień Agnieszka , Rzońca Ewa , Zarajczyk Marta , Wilkosz Katarzyna , Wdowiak Artur , Iwanowicz-Palus Grażyna 
Published: April 2020

AbstractPurposeThe aim of the study was to assess QoL and identify and analyse its determinants in women with endometriosis.MethodsThe study was performed in 2019 in health centres in Lublin (Poland) on 309 women with diagnosed endometriosis. In order to verify which factors affect QoL of the study participants, regression for qualitative variables (CATREG) was used. The applied research instruments included the WHOQOL-BREF quality of life questionnaire, the Acceptance of Illness Scale (AIS), the Laitinen Pain Scale, and a general questionnaire.ResultsThe overall QoL score of the respondents was 3.30, whereas their overall perceived health score was 2.37. The highest QoL scores were found for the psychological domain 13.33, whereas the lowest QoL were found for the physical domain 11.52. Women with endometriosis have a moderate level of illness acceptance (24.64) and experience daily pain of moderate intensity (5.83).ConclusionWomen with endometriosis rate their overall QoL higher than their overall perceived health. Perceived QoL in women with endometriosis is most commonly associated with their acceptance of illness, BMI, negative impact of symptoms on the relationship with the partner, and dyspareunia. To improve these women’s lives, care should also respond to the social, emotional, and sexual issues resulting from the illness. Such interventions will contribute to improved comfort and QoL among these women.