bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral Breast Abscess in a Newborn Baby
Authors: Aygün Erhan , Ertürk Emine Yurdakul , Kaya Haluk , Yalçın Onur 
Published: October 2020

Abstract
Background: In this study we wish to attract attention to mistaken interventions to the breast tissue of neonates and to increase awareness about this topic among personnel providing health services to neonates. Case presentation: A fourteen-day male infant was brought to the pediatric emergency clinic with swelling, redness, hardness and discharge complaints in the region of both breasts. Ultrasonography of the breast tissue of the patient identified appearance compatible with a dense-content abscess in the form of hyperechoic or hypoechoic avascular mass. Bilateral breast abscess responded to surgical and medical treatment. Conclusions: It is important to recognize physiological breast hypertrophy in newborns. In physiological hypertrophy, the breast bud is neither red nor soft and heals spontaneously. No intervention is required.
Associarions Between Fine Particulate Matter (PM2.5) and Childhood-Onset Systemic Lupus Erythematosus
Authors: Mai Chen-Hao , Shih Yen-Ju , Lin Cheng-Li , Wan Lei , Wei Chang-Ching 
Published: October 2020

Abstract
Background:Fine particulate matter (PM2.5) has been linked to induction of oxidative stress as well as pulmonary and systemic inflammation. We hypothesized that ambient PM2.5 variation would be associated with the occurrence of childhood-onset systemic lupus erythematosus (cSLE). Methods:We collected data from the Taiwan National health insurance research database and linked these data to the Taiwan Air Quality-Monitoring Database. Children <18 years old, identified from January 1, 2000 were followed up until the first diagnosis of cSLE was made or until December 31, 2012. The daily average PM2.5 was categorized into four quartile-based groups (Q1-Q4). We measured the incidence rate, hazard ratios (HRs), and 95% confidence intervals for cSLE stratified by the quartiles of PM2.5 concentration using Cox proportional hazards models adjusted for age, sex, monthly income, and urbanization. Results:A total of 394 children (0.16%) were newly diagnosed with cSLE during the observation period. The incidence rate for cSLE increased with PM2.5 levels, from 4.7 (Q1) to 21.9 (Q4) per 100,000 person-years. Compared with those exposed to the concentrations in the Q1 level, the adjusted HR from Q2 to Q4 for cSLE increased with PM2.5 exposure concentrations from 2.74 to 4.23. Conclusions:The present study provides evidence that long-term variations in PM2.5 levels are risk factors for the development of cSLE.
Minimally Invasive Plate Osteosynthesis with Dual Plating for Periprosthetic Distal Femoral Fractures Following Total Knee Arthroplasty
Authors: Park Yong-Geun , Kang Hyunseong , Song Jung-Kook , Lee Jaehwang , Rho Joseph Y. , Choi Sungwook 
Published: October 2020

Abstract
Introduction: Adequate treatment for periprosthetic distal femur fractures is challenging because of various reasons, including severe osteoporosis and distal fragments that are too small or too distal. We have introduced a new surgical technique for dual plating of periprosthetic distal femur fractures following total knee arthroplasty (TKA) and determined the clinical and radiological outcomes of minimally invasive plate osteosynthesis (MIPO) with a dual locking compression plate (LCP). Materials and methods: Between January 2010 and July 2019, 18 patients [mean age, 74.8 (68–89) years; average follow-up period, 14.8 (12–43) months)] underwent MIPO with distal femoral LCP laterally and proximal humeral internal locking system (PHILOS) medially for periprosthetic distal femoral fractures following TKA. The minimum follow-up was one year. The clinical and radiological outcomes were assessed using the modified WOMAC scores, knee range of motion, time to callus formation, time to union, and complications of malunion, nonunion, and shortening.Results: The average time to union was 18.4 weeks (range, 10–51 weeks) and to callus formation was 7.8 weeks (range, 2–14 weeks). At the one-year follow-up, the average JLETS was 37.6 (range, 24–53), average knee ROM was 110.3° (range, 80°–135°), and average varus-valgus angles of the distal femur were 3.2° (range, -2.9°–10.5°). No nonunion, broken plates, or implant failure occurred. Malunion occurred in three patients.Conclusion: MIPO with dual LCP is a reliable method for stabilizing periprosthetic distal femoral fractures following TKA, with satisfactory bone union rates and low complication rates.
Dental Pulp Stromal Cells Can Improve Muscle Dysfunction 1 in Animal Models of Duchenne Muscular Dystrophy
Authors: Kasahara Yuko Nitahara , Kuraoka Mutsuki , Guillermo Posadas Herrera , Kinoh Hiromi Hayashita , Maruoka Yasunobu , Takahashi Aki Nakamura , Kimura Koichi , Takeda Shin’ichi , Okada Takashi 
Published: October 2020

Abstract
Background: Duchenne muscular dystrophy (DMD) is an inherited progressive disorder that causes skeletal and cardiac muscle deterioration with chronic inflammation. Dental pulp stromal cells (DPSCs) are attractive candidates for cell-based strategies for DMD because of their immunosuppressive properties. Therefore, we hypothesized that systemic treatment with DPSCs might show therapeutic benefits as an anti-inflammatory therapy.Methods: To investigate the potential benefits of DPSC transplantation for DMD, we examined the disease progression in DMD animal model, mdx mice, by comparing them with different systemic treatment conditions. The DPSC-treated model, a canine X-linked muscular dystrophy model in Japan (CXMDJ), which has a severe phenotype similar to that of DMD patients, also underwent comprehensive analysis, including histopathological findings, muscle function, and locomotor activity.Results: We demonstrated a therapeutic strategy for the long-term functional recovery in DMD using repeated DPSC administration. DPSC-treated mdx mice and CXMDJ showed no serious adverse events. MRI findings and muscle histology suggested that DPSC treatment downregulated severe inflammation in DMD muscles and demonstrated a milder phenotype after DPSC treatment. DPSC-treated models showed an increased recovery in grip-hand strength and improved tetanic force and home-cage activity. Interestingly, maintenance of long-term running capability and stabilized cardiac function was also observed in 1-year-old DPSC-treated CXMDJ.Conclusions: We developed a novel strategy for the safe and effective transplantation of DPSCs for DMD recovery, including repeated systemic injection to regulate inflammation at a young age. This is the first report on the efficacy 58 of systemic DPSC treatment, from which we can propose that DPSCs may play an important role in delaying the DMD disease phenotype.
UL&nbsp;16 Binding Protein 3 Gene Expression: Does It Have an Association With Alopecia Areata?
Authors: Azmy Rania , Maraee Alaa , Amer Eman , Tayel Nermin , Shehata Wafaa Ahmed 
Published: October 2020

Abstract
ObjectiveAlopecia Areata is one of the most widespread autoimmune diseases affecting both sexes of all ages and across all ethnic individuals. Genetics is considered to be a valuable tool for gaining insight into the disease’s pathogenesis. Association with UL 16 Binding Protein (ULBP) genes has been detected with autoimmune disorders.This study aimed to detect UL-16 Binding Protein -3 (ULBP3) gene expression levels in cases with AA and to correlate those levels with the clinical course of the disease.This study included 85 subjects: 55 patients with AA and 30 age- and sex-matched healthy controls. The expression level of ULBP3 mRNA was estimated using Real-Time Polymerase Chain Reaction (RT-PCR).Results Levels of ULBP3 mRNA in cases were significantly higher in patients with AA in comparison with controls. Also, there were significant correlations between ULBP3 mRNA levels and age of patients and disease duration in years. ULBP3 upregulation in AA enforces the theory that postulates the autoimmune nature of AA and ULBP3 may be involved in AA pathogenesis and its progression.
Phylogenetic Relationship of Babesia Species Infecting Dogs from Select Regions of Kenya
Authors: Ngoka Ismail Thoya , Mbogo Kevin , Kyallo Martina , Juma Peter , Obiero David , Pelle Roger 
Published: October 2020

Abstract
There are over 100 Babesia species known to infect vertebrates with some of them being zoonotic. Local dog keeping practices enable extensive and intimate interactions between dogs, livestock, wildlife, and their human owners, thus allowing the possibility of dogs to act as hosts for zoonotic parasites.Canine babesiosis, known to occur in Kenya causes a severe and debilitating illness in dogs which compromises their welfare and capacity to carry out their role in society. Published data on Babesia species circulating among dogs in Kenya is limited. Improved control measures such as vaccines are required against the disease.The study design was descriptive and sampling opportunistic. A total of 143 whole blood samples were collected from domestic dogs in Nakuru, Nairobi and Mombasa counties. Total genomic DNA was extracted from each of the samples and screened for Babesia parasites using diagnostic PCR. Babesia species were identified through bioinformatic analysis of Sanger sequences.A total of 13 samples were positive for Babesia species (95% C.I is 0.0437 to 0.1381). Two were positive for Babesia canis vogeli, eleven were positive for Babesia canis rossi.77% of the Babesia positive samples were from Nairobi county.The study confirmed that molecular methods can be utilized to detect the presence of Babesia species circulating among dogs in Kenya.85% of the Babesia positive samples were Babesia canis rossi which causes the most severe form of canine babesiosis. Results of the bioinformatic analysis indicate 98.29% to 99.52% sequence identity to Babesia canis rossi obtained from black-backed jackals (Canis mesomelas).Babesia canis vogeli although primarily known as a domestic dog parasite has been shown capable of infecting both domestic and wild felines. This demonstrates the capacity of dogs to serve as hosts for pathogens from wildlife and vice versa.
Extremely wicked, shockingly evil and undoubtedly COVID-19: the silent serial killer
Authors: Guha Anasuya , Plzak Jan , Schalek Petr , Chovanec Martin 
Published: October 2020

Abstract
Background:The SARS-COV-2 virus has more than just an infectious role to play in the society. The rapid spread has also led to significant personal, professional, financial and economic recession globally. Health care professionals are getting seriously compromised due to these issues. No published data is available on the indirect effects of COVID-19 on high risk medical specialties. Otorhinolaryngology is considered as one such specialty. Hence we designed a national survey to address these issues.Materials and Methods: A google questionnaire was sent to all the otorhinolaryngologists in Czech Republic with the help of the Czech Society of Otorhinolaryngology and Head and Neck Surgery to evaluate the problems they encountered during the first wave of COVID-19. Personal, professional and financial losses were also addressed. Online access to the survey was from 15thApril 2020 to 26th April 2020.Results: The psychosomatic indirect impact of the disease affected female doctors than males. Burnout syndrome was the most commonly reported problem. Around 44.75% of all doctors had a combination of health, financial and economic as well as professional development and educational issues. Doctors from private practices faced higher financial losses.Conclusions: Our study showed that personal, professional and financial disturbances amongst doctors can lead to more serious consequences. With the lack of drastic measures in improving the support system for healthcare workers, the healthcare systems will fail quickly. Adequate support should be made mandatory by health authorities.
First report of southern root-knot nematode, Meloidogyne incognita, infecting Brassica nigra in Peru
Authors: Gómez-Chatata Jorge Airton , Tamo-Zegarra Juan José , Casa-Ruiz Teodocia Gloria , Bellé Cristiano 
Published: October 2020

Abstract

Brassica nigra plants showing symptoms caused by root-knot nematodes were detected in the municipality of La Joya, Arequipa Province, Peru. Based on morphology, esterase phenotypes, and species-specific characterized amplified region (SCAR) sequence, the causal agent was identified as Meloidogyne incognita. Pathogenicity was confirmed by a modified version of Koch’s postulates. To our knowledge, this is the first report of M. incognita infecting Brassica nigra in Peru.
Downscaling of ESA CCI soil moisture in Taihu Lake Basin: are wetness conditions and non-linearity important?
Authors: Liu Ya , Zhu Qing , Liao Kaihua , Lai Xiaoming , Wang Junbang 
Published: October 2020

Abstract
The coarse spatial resolutions of satellite-based soil moisture (SM) products restrict their applications at smaller spatial scales. In this study, the monthly European Space Agency Climate Change Initiative SM data (ESA CCI SM) from 2000 to 2016 was downscaled from 25- to 1-km resolution in the Taihu Lake Basin, a typical humid area with complex terrain and land uses. The normalized difference vegetation index (NDVI) and land surface temperature (LST) were used as auxiliary data. The regional monthly mean ESA CCI SM values were classified into low value (0.24–0.30 m3m–3), mid-value (0.30–0.33 m3m–3) and high value (0.33–0.39 m3m–3) months by the K-means clustering algorithm. The linear (multiple linear regression) and non-linear (support vector machine) downscaling models were compared. In addition, whether building downscaling models based on wetness conditions could improve the accuracies was tested. Results showed that without considering wetness conditions, the linear method was slightly better than the non-linear method. However, linear models constructed based on wetness conditions performed the best, which demonstrated that wetness conditions should be considered in the downscaling process. Results of this study would improve the accuracies in downscaling satellite-based SM data, facilitating their applications at regional scales.
Preparation of poly-dopamine-silk fibroin sponge and its dye molecular adsorption
Authors: Duan Ming , Tang Qingqing , Wang Manlin , Luo Mengjuan , Fang Shenwen , Wang Xiujun , Shi Peng , Xiong Yan 
Published: October 2020

Abstract
This paper proposes a process for fabricating a poly-dopamine-silk fibroin sponge (PDA-SF) by using dopamine self-assembly and coating the skeleton of a silk fibroin sponge. The PDA-SF sponge was characterized by SEM, TEM, XPS, XRD and FT-IR. It was found that the sponge exhibits sheet structures with a pore size of 60 ± 20 μm and poly-dopamine adhered to the surface of pure silk fibroin through noncovalent bond forces. With a hierarchical porous structure, the derived sponge provides fast flow channels and abundant active sites, which will benefit the diffusion and removal of cationic dyes. Batch adsorption and dynamic adsorption of crystal violet (CV) were studied. The batch adsorption capacity of the PDA-SF sponge for CV increased with its PDA content. Under a dynamic adsorption mode, the adsorption efficiency of the PDA-SF sponge for CV (5 mg/L, 200 mL) can reach up to 98.2% after 12 min, whereas it is only 90.2% under stationary mode after 72 h. Furthermore, the sponge shows an outstanding smart adsorption performance. More importantly, the composite sponge still keeps high separation and adsorption efficiencies after 20 cycles, and the appearance remains good.
Renal-Protective Activity of Dried Gel of Aloe barbadensis (Elwa) on Gentamicin-
Induced Nephrotoxicity in Albino Rats
Authors: Aslam M. , Rahman Shabana , Javed Kalim , Nazeem Fahamiya , Mohamed Shiffa 
Published: October 2020

Introduction::
Elwa (Aloe barbadensis / Aloe vera) also known as Sibr in Unani medicine which is dried juice
obtained by the inspissations and used to treat many diseases, especially digestive disorders, arthritis, gastric ulcer, jaundice,
amenorrhoea, kidney diseases, diseases of spleen and liver, constipation, nervine disorders, wounds, burns, scalds
and other skin diseases.

Methods::
The aim of this study was to evaluate the nephroprotective activity of Aloe barbadensis
gel (ABG) on gentamicin-induced nephrotoxicity in rats. Wistar rats were divided into four groups of six animals
in each. Group I (control); group II, III and IV were administered gentamicin 100 mg/kg/d subcutaneously from day four
to eight. The lower (350 mg/kg) and higher doses (1260 mg/kg) of crude ABG were co-administrated orally in group III
and group IV from day 1. On 9th day animals were sacrificed and serum was studied for blood urea nitrogen and serum
creatinine and kidneys were prepared for histo-pathological analysis. Gentamicin alone treated group showed increased
levels of blood urea nitrogen (118.76  0.90) and creatinine (3.42  0.13) were significantly inhibited in groups pretreated
with lower [blood urea nitrogen (40.130.56); creatinine (1.640.13)] and higher [blood urea nitrogen (55.79  0.71); creatinine
(2.50  0.06)] doses of crude Aloe barbadensis gel.

Results::
The histopathological analysis also showed the protective
nature of Aloe barbadensis gel in gentamicin-induced renal damage.

Discussion::
In conclusion, the biochemical
parameters and histopathological results confirmed nephroprotective effect of the crude Aloe barbadensis gel against gentamicin
induced renal damage.
Investigation and Reliability Analysis of Fifteen-level Asymmetrical Multilevel Inverter Topology using Nearest Level Control Technique with low Component Count
Authors: Roy Abeera D. , Umayal Chandrahasan 
Published: October 2020

Background::
In multilevel inverters (MLI) as the number of level increases, there is a proportionate increase in
the count of the semiconductor devices that are employed.

Methods::
An asymmetrical multilevel inverter topology using a bidirectional switch is presented which employs lesser
number of power electronic devices to produce fifteen levels at the output voltage. Nearest Level modulation (NLM)
technique is used to generate the switching pulses and reliability analysis is performed using Markov reliability
methodology. The operating principle of the proposed MLI and its performance abilities is verified through
MATLAB/Simulink and a prototype is developed to provide the experimental results.

Results::
Total Harmonic Distortion (THD) is computed for proposed MLI for different types of loads in simulation
environment as well as in the developed hardware prototype. The fifteen level is achieved by using only 9 switches and 3
DC sources in comparison to the 28 switches and 6 DC sources required by the traditional cascaded H-bridge inverter.

Conclusion::
The simulation and hardware results confirm the suitability of the proposed fifteen level MLI as the total
component count and the requirement of DC sources reduces considerably.
The Hospital-Community-Family–Based Telemedicine (HCFT-AF) Program for Integrative Management of Patients With Atrial Fibrillation: Pilot Feasibility Study
Authors: Jiang Jiang , Gu Xiang , Cheng Chen-Di , Li Hong-Xiao , Sun Xiao-Lin , Duan Ruo-Yu , Zhu Ye , Sun Lei , Chen Fu-Kun , Bao Zheng-Yu , Zhang Yi , Shen Jian-Hua 
Published: October 2020

Background
The potential effectiveness of integrated management in further improving the prognosis of patients with atrial fibrillation has been demonstrated; however, the best strategy for implementation remains to be discovered.

Objective
The aim of this study was to ascertain the feasibility of implementing integrated atrial fibrillation care via the Hospital-Community-Family–Based Telemedicine (HCFT-AF) program.

Methods
In this single-arm, pre-post design pilot study, a multidisciplinary teamwork, supported by efficient infrastructures, provided patients with integrated atrial fibrillation care following the Atrial fibrillation Better Care (ABC) pathway. Eligible patients were continuously recruited and followed up for at least 4 months. The patients’ drug adherence, and atrial fibrillation–relevant lifestyles and behaviors were assessed at baseline and at 4 months. The acceptability, feasibility, and usability of the HCFT-AF technology devices and engagement with the HCFT-AF program were assessed at 4 months.

Results
A total of 73 patients (mean age, 68.42 years; 52% male) were enrolled in November 2019 with a median follow up of 132 days (IQR 125–138 days). The patients’ drug adherence significantly improved after the 4-month intervention (P<.001). The vast majority (94%, 64/68) of indicated patients received anticoagulant therapy at 4 months, and none of them received antiplatelet therapy unless there was an additional indication. The atrial fibrillation–relevant lifestyles and behaviors ameliorated to varying degrees at the end of the study. In general, the majority of patients provided good feedback on the HCFT-AF intervention. More than three-quarters (76%, 54/71) of patients used the software or website more than once a week and accomplished clinic visits as scheduled.

Conclusions
The atrial fibrillation–integrated care model described in this study is associated with improved drug adherence, standardized therapy rate, and lifestyles of patients, which highlights the possibility to better deliver integrated atrial fibrillation management.

Trial Registration
Clinicaltrials.gov NCT04127799; https://clinicaltrials.gov/ct2/show/NCT04127799
Identifikasi Bahaya Psikososial Pada Buruh Wanita Di Pabrik Karet
Authors: Andarini Desheila , Putra Pacu , Puspasari Maya , Listianti Ani Nidia , Putri Sasviana 
Published: October 2020

Pekerja informal berjumlah 1,8 miliar (60% dari angkatan kerja global) dan menghadapi insekuritas dan stres kerja yang lebih besar daripada pekerja yang dipekerjakan secara formal, dan mereka tidak memiliki akses terhadap pelayanan kesehatan yang terjangkau dan perawatan kesehatan yang berkualitas. Buruh perempuan merupakan salah satu komunitas yang rentan terhadap masalah kesehatan. Buruh perempuan yang telah menikah dan punya anak memiliki peran dan tanggung jawab yang lebih berat daripada wanita single. Ketidakpuasan dan insekuritas terhadap lingkungan pekerjaan yang merupakan bahaya psikososial dapat berdampak negatif pada kesehatan buruh tersebut. Tujuan penelitian ini adalah untuk menganalisis identifikasi bahaya psikososial pada buruh wanita di pabrik karet. Informan dalam penelitian ini adalah pekerja buruh wanita di pabrik karet sebanyak delapan orang. Metode penelitian adalah kualitatif dengan melakukan identifikasi terhadap risiko bahaya psikososial pada buruh wanita di pabrik karet. Hasil penelitian diketahui bahwa bahaya psikososial yang teridentifikasi diantaranya adalah risiko stress di tempat kerja berupa hubungan interpersonal dan beban kerja. Dengan teridentifikasi risiko psikososial di tempat kerja maka perusahaan perlu menerapkan tindakan pencegahan agar buruh wanita mendapatkan perlindungan di tempat kerja.