bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric Properties of the Brief Resilient Coping Scale in a Sample of Stable Severe Mental Disorder Patients
Authors: Mayordomo Teresa , Rubio-Belmonte César , García-Alandete Joaquín , Aragonés-Barberá Inmaculada 
Published: June 2020

Abstract
The aim of this study was to analyze the psychometric properties of the Brief Resilient Coping Scale (BRCS). 57 stable severe mental disorder patients (42 men, 73.7%, and 15 women, 26.3%), ranging in age between 23 and 64 years, (M = 46.25; SD = 7.52) answered to the BRCS and the World Health Organization Quality of Life Assessment (WHOQOL-BREF). Descriptive analyses, estimations of internal consistency, and confirmatory factor analysis were conducted, and correlations between the BRCS and the WHOQOL-BREF were calculated. The factorial validity of the scale was tested using confirmatory factor analysis, with a single dimension of resilience. The BRCS showed acceptable internal consistency (alpha of .69). Correlations between the BRCS and WHOQOL-BREF were positive, r(PhH-R) = .42, r(PsH-R) = .40, r(SR-R) = .33, r(E-R) = .35, and significant (p < .01). In conclusion, the Spanish adaptation of the BRCS seems to be a reliable and valid measure of resilience in stable severe mental disorder patients.
Nick Martin’s Contribution to GxE Research
Authors: Colodro-Conde Lucía , Couvy-Duchesne Baptiste 
Published: June 2020

AbstractThe study and identification of genotype–environment interactions (GxE) has been a hot topic in the field of human genetics for several decades. Yet the extent to which GxE contributes to human behavior variability, and its mechanisms, remains largely unknown. Nick Martin has contributed important advances to the field of GxE for human behavior, which include methodological developments, novel analyses and reviews. Here, we will first review Nick’s contributions to the GxE research, which started during his PhD and consistently appears in many of his over 1000 publications. Then, we recount a project that led to an article testing the diathesis-stress model for the origins of depression. In this publication, we observed the presence of an interaction between polygenic risk scores for depression (the risk in our ‘genotype’) and stressful life events (the experiences from our ‘environment’), which provided the first empirical support of this model.
Arg-128-Leu target-site mutation in PPO2 evolves in wild poinsettia (Euphorbia heterophylla) with cross-resistance to PPO-inhibiting herbicides
Authors: Mendes Rafael R. , Takano Hudson K. , Adegas Fernando S. , Oliveira Rubem S. , Gaines Todd A. , Dayan Franck E. 
Published: June 2020

AbstractWild poinsettia (Euphorbia heterophylla L.) is a troublesome broadleaf weed in grain production areas in South America. Herbicide resistance to multiple sites of action has been documented in this species, including protoporphyrinogen oxidase (PPO) inhibitors. We investigated the physiological and molecular bases for PPO-inhibitor resistance in a E. heterophylla population (RPPO) from Southern Brazil. Whole-plant dose–response experiments revealed a cross-resistance profile to three different chemical groups of PPO inhibitors. Based on dose–response parameters, RPPO was resistant to lactofen (47.7-fold), saflufenacil (8.6-fold), and pyraflufen-ethyl (3.5-fold). Twenty-four hours after lactofen treatment (120 g ha−1) POST, RPPO accumulated 27 times less protoporphyrin than the susceptible population (SPPO). In addition, RPPO generated 5 and 4.5 times less hydrogen peroxide and superoxide than SPPO, respectively. The chloroplast PPO (PPO1) sequences were identical between the two populations, whereas 35 single-nucleotide polymorphisms were found for the mitochondrial PPO (PPO2). Based on protein homology modeling, the Arg-128-Leu (homologous to Arg-98-Leu in common ragweed [Ambrosia artemisiifolia L.] was the only one located near the catalytic site, also in a conserved region of PPO2. The cytochrome P450 monooxygenase inhibitor malathion did not reverse resistance to lactofen in RPPO, and both populations showed similar levels of PPO1 and PPO2 expression, suggesting that metabolic resistance and PPO overexpression are unlikely. This is the first report of an Arg-128-Leu mutation in PPO2 conferring cross-resistance to PPO inhibitors in E. heterophylla.
FFT‐Based Multiband Spectrum Sensing in SIMO In‐band Full‐Duplex Cognitive Radio Networks
Authors:   Tripta, Kumar Abhishek , Saha Seemanti 
Published: June 2020

AbstractThis paper presents fast Fourier transform (FFT)‐based multiband spectrum sensing over multipath Rayleigh frequency selective fading channels in single input multiple output (SIMO) in‐band full‐duplex (FD) cognitive radio (CR) networks (FDCRNs) under residual self‐interference (RSI). In this work, first, multiband energy detection using Neyman Pearson criterion is proposed in FDCRNs under RSI, where the secondary user is equipped with multiple receive antennas to exploit spatial diversity. Next, a two‐dimensional averaging is done to overcome spectrum leakage problem occurring due to FFT operation in orthogonal frequency division multiplexing (OFDM) system. The closed form expressions for average probability of detection and probability of false alarm are derived for SIMO FDCRNs under RSI. Further, RSI cancelation is performed employing noise robust wavelet decomposition‐based least squares scheme and the corresponding simulation studies indicate that the proposed algorithm further improves the detection performance in SIMO FDCRNs.
Clozapine modulates retinoid homeostasis in human brain and normalizes serum retinoic acid deficit in patients with schizophrenia
Authors: Regen Francesca , Cosma Nicoleta-Carmen , Otto Lisa R. , Clemens Vera , Saksone Lana , Gellrich Janine , Uesekes Berk , Ta Thi Minh Tam , Hahn Eric , Dettling Michael , Heuser Isabella , Hellmann-Regen Julian 
Published: June 2020

AbstractThe atypical antipsychotic clozapine is one of the most potent drugs of its class, yet its precise mechanisms of action remain insufficiently understood. Recent evidence points toward the involvement of endogenous retinoic acid (RA) signaling in the pathophysiology of schizophrenia. Here we investigated whether clozapine may modulate RA-signaling. Effects of clozapine on the catabolism ofall-transRA (at-RA), the biologically most active metabolite of Vitamin A, were assessed in murine and human brain tissue and peripheral blood-derived mononuclear cells (PBMC). In patients with schizophrenia with and without clozapine treatment and matched healthy controls,at-RA serum levels and blood mRNA expression of retinoid-related genes in PBMCs were quantified. Clozapine and its metabolites potently inhibited RA catabolism at clinically relevant concentrations. In PBMC-derived microsomes, we found a large interindividual variability of the sensitivity toward the effects of clozapine. Furthermore,at-RA and retinol serum levels were significantly lower in patients with schizophrenia compared with matched healthy controls. Patients treated with clozapine exhibited significantly higherat-RA serum levels compared with patients treated with other antipsychotics, while retinol levels did not differ between treatment groups. Similarly, in patients without clozapine treatment, mRNA expression of RA-inducible targets CYP26A and STRA6, as well as at-RA/retinol ratio, were significantly reduced. In contrast, clozapine-treated patients did not differ from healthy controls in this regard. Our findings provide the first evidence for altered peripheral retinoid homeostasis in schizophrenia and suggest modulation of RA catabolism as a novel mechanism of action of clozapine, which may be useful in future antipsychotic drug development.
Ecological succession in the vaginal microbiota during pregnancy and birth
Authors: Rasmussen M A , Thorsen J , Dominguez-Bello M G , Blaser M J , Mortensen M S , Brejnrod A D , Shah S A , Hjelmsø M H , Lehtimäki J , Trivedi U , Bisgaard H , Sørensen S J , Stokholm J 
Published: June 2020

Abstract
The mother’s vaginal microbiota represents the first microbes to which a child is exposed when delivered vaginally. However, little is known about the composition and development of the vaginal microbiota during pregnancy and birth. Here, we analyzed the vaginal microbiota of 57 women in pregnancy week 24, 36 and at birth after rupture of membranes but before delivery, and further compared the composition with that of the gut and airways of the 1-week-old child. The vaginal community structure had dramatic changes in bacterial diversity and taxonomic distribution, yet carried an individual-specific signature. The relative abundance of most bacterial taxa increased stepwise from week 24 of pregnancy until birth, with a gradual decline of Lactobacillus. Mother-to-child vertical transfer, as suggested by sharing, was modest, with the strongest transfer being for Clostridiales followed by Lactobacillales and Enterobacteriales. In conclusion, late gestation is associated with an increase in maternal vaginal microbiota diversity, and vaginal bacteria at birth only modestly predict the composition of the neonatal microbiota.
Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription
Authors: Wan Guoqing , Zhu Jiang , Gu Xuefeng , Yang Yue , Liu Yihao , Wang Zhizheng , Zhao Yuxia , Wu Hailong , Huang Gang , Lu Changlian 
Published: June 2020

Abstract
Background
Human Schlafen 5 (SLFN5) has been reported to inhibit or promote cell invasion in tumours depending on their origin. However, its role in breast cancer (BRCA) is undetermined.

Methods
Differential expression analyses using The Cancer Genome Atlas (TCGA) data, clinical samples and cell lines were performed. Lentiviral knockdown and overexpression experiments were performed to detect changes in cell morphology, molecular markers and invasion. Chromatin immunoprecipitation-sequencing (ChIP-Seq) and luciferase reporter assays were performed to detect the SLFN5-binding motif.

Results
TCGA, clinical samples and cell lines showed that SLFN5 expression was negatively correlated with BRCA metastasis. SLFN5 knockdown induced epithelial–mesenchymal transition (EMT) and enhanced invasion in BRCA cell lines. However, overexpression triggered mesenchymal–epithelial transition (MET). SLFN5 inhibited the expression of ZEB1 but not ZEB2, SNAI1, SNAI2, TWIST1 or TWIST2. Knockdown and overexpression of ZEB1 indicated that it was a mediator of the SLFN5-governed phenotype and invasion changes. Moreover, SLFN5 inhibited ZEB1 transcription by directly binding to the SLFN5-binding motif on the ZEB1 promoter, but a SLFN5 C-terminal deletion mutant did not.

Conclusion
SLFN5 regulates reversible epithelial and mesenchymal transitions, and inhibits BRCA metastasis by suppression of ZEB1 transcription, suggesting that SLFN5 could be a potential target for BRCA therapy.
mTOR-Myc axis drives acinar-to-dendritic cell transition and the CD4+ T cell immune response in acute pancreatitis
Authors: Xu Dan , Xie Rongli , Xu Zhiwei , Zhao Zhifeng , Ding Min , Chen Wei , Zhang Jun , Mao Enqiang , Chen Erzhen , Chen Ying , Yang Kaige , Zhou Tong , Fei Jian 
Published: June 2020

AbstractThe inflammatory response in acute pancreatitis (AP) is associated with acinar-to-dendritic cell transition. The CD4+ T-cell-mediated adaptive immune response is necessary for pancreatic inflammatory damage. However, the effect of acinar-to-dendritic cell transition on the CD4+ T-cell response and the regulatory mechanism remain undefined. A mouse animal model of AP was established by repeated intraperitoneal injection of CAE. The mTOR inhibitor rapamycin was administered before AP induction. Primary acinar cells were isolated and co-incubated with subsets of differentiated CD4+ T cells. The expression of DC-SIGN was also assessed in pancreatic tissues from human AP patients. We found acinar cells expressed DC-SIGN and displayed the phenotype of dendritic cells (DCs), which promoted the differentiation of naive CD4+ T cells into CD4+/IFN-γ+ Th1 and CD4+/IL-17A+ Th17 cells in pancreatic tissues during AP. DC-SIGN was the target gene of Myc. The mTOR inhibitor rapamycin inhibited AP-induced DC-SIGN expression, CD4+ Th1/Th17 cell differentiation and the pro-inflammatory response via Myc. Acinar cells expressed DC-SIGN in pancreatic tissues of human patients with AP. In conclusion, acinar-to-dendritic cell transition is implicated in the CD4+ T-cell immune response via mTOR-Myc-DC-SIGN axis, which might be an effective target for the prevention of local pancreatic inflammation in AP.
Very sharp diffraction peak in nonglass-forming liquid with the formation of distorted tetraclusters
Authors: Koyama Chihiro , Tahara Shuta , Kohara Shinji , Onodera Yohei , Småbråten Didrik R. , Selbach Sverre M. , Akola Jaakko , Ishikawa Takehiko , Masuno Atsunobu , Mizuno Akitoshi , Okada Junpei T. , Watanabe Yuki , Nakata Yui , Ohara Koji , Tamaru Haruka , Oda Hirohisa , Obayashi Ippei , Hiraoka Yasuyuki , Sakata Osami 
Published: June 2020

AbstractUnderstanding the liquid structure provides information that is crucial to uncovering the nature of the glass-liquid transition. We apply an aerodynamic levitation technique and high-energy X-rays to liquid (l)-Er2O3 to discover its structure. The sample densities are measured by electrostatic levitation at the International Space Station. Liquid Er2O3 displays a very sharp diffraction peak (principal peak). Applying a combined reverse Monte Carlo – molecular dynamics approach, the simulations produce an Er–O coordination number of 6.1, which is comparable to that of another nonglass-forming liquid, l-ZrO2. The atomic structure of l-Er2O3 comprises distorted OEr4 tetraclusters in nearly linear arrangements, as manifested by a prominent peak observed at ~180° in the Er–O–Er bond angle distribution. This structural feature gives rise to long periodicity corresponding to the sharp principal peak in the X-ray diffraction data. A persistent homology analysis suggests that l-Er2O3 is homologically similar to the crystalline phase. Moreover, electronic structure calculations show that l-Er2O3 has a modest band gap of 0.6 eV that is significantly reduced from the crystalline phase due to the tetracluster distortions. The estimated viscosity is very low above the melting point for l-ZrO2, and the material can be described as an extremely fragile liquid.
Cephalopod-inspired optical engineering of human cells
Authors: Chatterjee Atrouli , Cerna Sanchez Juana Alejandra , Yamauchi Toyohiko , Taupin Vanessa , Couvrette Justin , Gorodetsky Alon A. 
Published: June 2020

AbstractAlthough many animals have evolved intrinsic transparency for the purpose of concealment, the development of dynamic, that is, controllable and reversible, transparency for living human cells and tissues has remained elusive to date. Here, by drawing inspiration from the structures and functionalities of adaptive cephalopod skin cells, we design and engineer human cells that contain reconfigurable protein-based photonic architectures and, as a result, possess tunable transparency-changing and light-scattering capabilities. Our findings may lead to the development of unique biophotonic tools for applications in materials science and bioengineering and may also facilitate an improved understanding of a wide range of biological systems.
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
Authors: Toda Haruka , Diaz-Varela Miriam , Segui-Barber Joan , Roobsoong Wanlapa , Baro Barbara , Garcia-Silva Susana , Galiano Alicia , Gualdrón-López Melisa , Almeida Anne C. G. , Brito Marcelo A. M. , de Melo Gisely Cardoso , Aparici-Herraiz Iris , Castro-Cavadía Carlos , Monteiro Wuelton Marcelo , Borràs Eva , Sabidó Eduard , Almeida Igor C. , Chojnacki Jakub , Martinez-Picado Javier , Calvo Maria , Armengol Pilar , Carmona-Fonseca Jaime , Yasnot Maria Fernanda , Lauzurica Ricardo , Marcilla Antonio , Peinado Hector , Galinski Mary R. , Lacerda Marcus V. G. , Sattabongkot Jetsumon , Fernandez-Becerra Carmen , del Portillo Hernando A. 
Published: June 2020

AbstractPlasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen.
Attosecond science based on high harmonic generation from gases and solids
Authors: Li Jie , Lu Jian , Chew Andrew , Han Seunghwoi , Li Jialin , Wu Yi , Wang He , Ghimire Shambhu , Chang Zenghu 
Published: June 2020

AbstractRecent progress in high power ultrafast short-wave and mid-wave infrared lasers has enabled gas-phase high harmonic generation (HHG) in the water window and beyond, as well as the demonstration of HHG in condensed matter. In this Perspective, we discuss the recent advancements and future trends in generating and characterizing soft X-ray pulses from gas-phase HHG and extreme ultraviolet (XUV) pulses from solid-state HHG. Then, we discuss their current and potential usage in time-resolved study of electron and nuclear dynamics in atomic, molecular and condensed matters.
Mantle data imply a decline of oxidizable volcanic gases could have triggered the Great Oxidation
Authors: Kadoya Shintaro , Catling David C. , Nicklas Robert W. , Puchtel Igor S. , Anbar Ariel D. 
Published: June 2020

AbstractAerobic lifeforms, including humans, thrive because of abundant atmospheric O2, but for much of Earth history O2 levels were low. Even after evidence for oxygenic photosynthesis appeared, the atmosphere remained anoxic for hundreds of millions of years until the ~2.4 Ga Great Oxidation Event. The delay of atmospheric oxygenation and its timing remain poorly understood. Two recent studies reveal that the mantle gradually oxidized from the Archean onwards, leading to speculation that such oxidation enabled atmospheric oxygenation. But whether this mechanism works has not been quantitatively examined. Here, we show that these data imply that reducing Archean volcanic gases could have prevented atmospheric O2 from accumulating until ~2.5 Ga with ≥95% probability. For two decades, mantle oxidation has been dismissed as a key driver of the evolution of O2 and aerobic life. Our findings warrant a reconsideration for Earth and Earth-like exoplanets.
Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals
Authors: Kaur Satvinder , De Luca Roberto , Khanday Mudasir A. , Bandaru Sathyajit S. , Thomas Renner C. , Broadhurst Rebecca Y. , Venner Anne , Todd William D. , Fuller Patrick M. , Arrigoni Elda , Saper Clifford B. 
Published: June 2020

AbstractDuring obstructive sleep apnea, elevation of CO2 during apneas contributes to awakening and restoring airway patency. We previously found that glutamatergic neurons in the external lateral parabrachial nucleus (PBel) containing calcitonin gene related peptide (PBelCGRP neurons) are critical for causing arousal during hypercapnia. However, others found that genetic deletion of serotonin (5HT) neurons in the brainstem also prevented arousal from hypercapnia. To examine interactions between the two systems, we showed that dorsal raphe (DR) 5HT neurons selectively targeted the PBel. Either genetically directed deletion or acute optogenetic silencing of DRSert neurons dramatically increased the latency of mice to arouse during hypercapnia, as did silencing DRSert terminals in the PBel. This effect was mediated by 5HT2a receptors which are expressed by PBelCGRP neurons. Our results indicate that the serotonergic input from the DR to the PBel via 5HT2a receptors is critical for modulating the sensitivity of the PBelCGRP neurons that cause arousal to rising levels of blood CO2.
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
Authors: Hoque Kazi Mirajul , Dixon Eryn E. , Lewis Raychel M. , Allan Jordyn , Gamble Gregory D. , Phipps-Green Amanda J. , Halperin Kuhns Victoria L. , Horne Anne M. , Stamp Lisa K. , Merriman Tony R. , Dalbeth Nicola , Woodward Owen M. 
Published: June 2020

AbstractThe pathophysiological nature of the common ABCG2 gout and hyperuricemia associated variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that participants with the Q141K ABCG2 variant display elevated serum urate, unaltered FEUA, and significant evidence of reduced extra-renal urate excretion. We explore mechanisms by generating a mouse model of the orthologous Q140K Abcg2 variant and find male mice have significant hyperuricemia and metabolic alterations, but only subtle alterations of renal urate excretion and ABCG2 abundance. By contrast, these mice display a severe defect in ABCG2 abundance and function in the intestinal tract. These results suggest a tissue specific pathobiology of the Q141K variant, support an important role for ABCG2 in urate excretion in both the human kidney and intestinal tract, and provide insight into the importance of intestinal urate excretion for serum urate homeostasis.
Spherical trihedral metallo-borospherenes
Authors: Chen Teng-Teng , Li Wan-Lu , Chen Wei-Jia , Yu Xiao-Hu , Dong Xin-Ran , Li Jun , Wang Lai-Sheng 
Published: June 2020

AbstractThe discovery of borospherenes unveiled the capacity of boron to form fullerene-like cage structures. While fullerenes are known to entrap metal atoms to form endohedral metallofullerenes, few metal atoms have been observed to be part of the fullerene cages. Here we report the observation of a class of remarkable metallo-borospherenes, where metal atoms are integral parts of the cage surface. We have produced La3B18– and Tb3B18– and probed their structures and bonding using photoelectron spectroscopy and theoretical calculations. Global minimum searches revealed that the most stable structures of Ln3B18– are hollow cages with D3h symmetry. The B18-framework in the Ln3B18– cages can be viewed as consisting of two triangular B6 motifs connected by three B2 units, forming three shared B10 rings which are coordinated to the three Ln atoms on the cage surface. These metallo-borospherenes represent a new class of unusual geometry that has not been observed in chemistry heretofore.