bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studi Komparatif Perkembangan Daya Tahan Anak Putra Usia 9 Tahun Berdasarkan Tempat Tinggal di Wilayah Kabupten Malang
Authors: Ansori Ahzar Halim , Asim Asim , Amiq Fahrial 
Published: November 2019

Abstract: This research was aimed to find out if there is a difference in endurance level of 9-year-old children living in lowland, plains, and plateau areas in Malang district. It used a survey method with cross-sectional approach to gain the data. The data analysis used one way variance analysis with the α=0.05. based on the one way variance analysis, it showed the probability was 0.000 < 0.05, so the H0 was rejected. It meant that there was a difference endurance level of 9-years-old children living in lowland, plains, and plateau areas. The results of the anava analysis showed that the lowlands were better than the temperate plains, and the highlands were better than the low and plains.Keywords: The level of resistance the heart children aged 9 years living in the lowlands, Plains, and Plateaus. Abstrak: Penelitian ini bertujuan untuk mengetahui apakah ada perbedaan tingkat daya tahan pada anak putra usia 9 tahun yang tinggal di daerah dataran rendah, dataran sedang, dan dataran tinggi di wilayah Kabupaten Malang. Jenis penelitian menggunakan metode survei dengan pendekatan cross-sectional. Analisis data menggunakan analisis varians satu arah dengan α=0,05. Berdasarkan analisis varians satu arah menunjukkan probabilitas 0,000 < 0,05, maka H0 ditolak dan H1 diterima, yang berarti terdapat perbedaan perkembangan daya tahan pada anak usia 9 tahun, yang tinggal di dataran rendah, dataran sedang dan dataran tinggi. Hasil analisis anava menunjukkan bahwa dataran rendah lebih baik daripada dataran sedang, dan dataran tinggi lebih baik daripada dataran rendah dan sedang. Kata Kunci: Tingkat Daya Tahan Anak Usia 9 Tahun Yang Tinggal di Dataran Rendah, Dataran Sedang, dan Dataran Tinggi.
Twenty Years of a Pre-Symptomatic Testing Protocol for Late-Onset Neurological Diseases in Portugal
Authors: Paneque Milena , Félix Joana , Mendes Álvaro , Lemos Carolina , Lêdo Susana , Silva João , Sequeiros Jorge 
Published: November 2019

Introduction: The national protocol of genetic counselling and pre-symptomatic testing for late-onset neurological diseases began in Portugal in 1995. Initially, it was accessible only to adults at-risk for Machado-Joseph disease, but was later extended to other hereditary ataxias, to Huntington’s disease and to familial amyloid polyneuropathy caused by Val30Met mutation at the transthyretin gene. The aim of this study was to describe the profile of the population seeking pre-symptomatic testing, while also reflecting on the experience of conducting the protocol of multidisciplinary sessions since 1996.Material and Methods: We conducted a retrospective study and collected data from clinical records of consultands who requested pre-symptomatic testing at our centre in Porto (Portugal) during the first twenty years of practice (1996 - 2015).Results: A total of 1446 records were reviewed. The most common reason for testing was to reduce uncertainty (41.7%). The rate of withdrawals before results disclosure was lower (16%) than reported in other international experiences with pre-symptomatic testing, while 45% of the consultands dropped out the protocol after learning the test results (73.5% of them were non-carriers). As far as the mutation carriers were concerned, 29.6% adhered to the protocol a year after test disclosure. Consultands that had learned about presymptomatic testing through healthcare professionals tended to adhere more to pre-symptomatic testing consultations.Discussion: The profile of Portuguese consultands at risk for late-onset neurological diseases is similar to those reported in other international programs. The largest group in this data set was the one comprising the subjects at risk for familial amyloid polyneuropathy caused by Val30Met mutation at the transthyretin gene, and it is likely that therapeutic options for this condition may have influenced this result. Adherence to pre-symptomatic testing may change in the future since effective therapies are available (or given the fact that people think effective treatments are imminent).Conclusion: This study reflects the first comprehensive description of a Portuguese experience with pre-symptomatic testing for late onset neurological diseases. The development of innovative approaches to improve the consultands’ experience with pre-symptomatic testing and their engagement in genetic departments is still a challenge in Portuguese genetics healthcare departments. A better coordination among primary care and genetics healthcare services is needed.
Validação do The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) em Estudantes Universitários
Authors: Mostardinha António Ramalho , Bártolo Ana , Bonifácio José , Pereira Anabela 
Published: November 2019

Introdução: Este estudo objetiva adaptar culturalmente e explorar as propriedades psicométricas da versão portuguesa do the Alcohol, Smoking and Substance Involvement Screening Test em estudantes do ensino superior.Material e Métodos: Estudo de validação, transversal, com dados recolhidos através de questionário composto por questões sociodemográficas e medidas para avaliação do consumo de substâncias (teste de Fagerström para dependência nicotínica; Drinking Motives Questionnaire – Revised e The Alcohol, Smoking and Substance Involvement Screening Test versão 3.1). A amostra foi constituída por 338 estudantes (51,8% homens), com uma idade média de 20,6 anos (desvio-padrão = 3,4). A análise fatorial exploratória foi utilizada para o estudo da estrutura fatorial. Foram ainda avaliadas a consistência interna e a validade convergente.Resultados: As subescalas ‘Tabaco’ e ‘Cannabis’ apresentaram-se ambas compostas por um único fator e a de ‘Bebidas Alcoólicas’ por dois fatores. A consistência interna variou entre 0,556 e 0,842 (ɑ de Cronbach). Observaram-se associações estatisticamente significativas entre ser fumador, binge-drinking e motivos de consumos etílicos com consumos de risco (subescalas ‘Tabaco’, ‘Bebidas Alcoólicas’ e ‘Cannabis’).Discussão: As associações observadas entre os consumos de risco, os motivos de consumos e os comportamentos de consumo, poderão ser explicadas pela relação entre o consumo de álcool (como parte da experiência académica) com o comportamento de consumo de substâncias e consumos concorrentes, fundamentando a adequada validade convergente observada. Ainda, a pressão de pares poderá influenciar estes comportamentos relativamente a consumos.Conclusão: A versão em Português europeu do the Alcohol, Smoking and Substance Involvement Screening Test (‘Tabaco’, ‘Bebidas Alcoólicas’ e ‘Cannabis’) apresentou características psicométricas satisfatórias, mostrando ser uma ferramenta confiável para avaliar consumos de risco em estudantes universitários.
Pendekatan Rasio Fibonacci Dan Fuzzy Logic Sebagai Analisis Teknikal Dalam Menentukan Keputusan Investasi Saham
Authors: Meiliza Dewi Ratiwi , Prasojo Bayu Hari 
Published: November 2019

One form of approach used to analyze stock prices is by applying Fibonacci ratios and Fuzzy Logic analysis. The purpose of this study is (1) to apply the Fibonacci ratio approach to determine stock support and resistance levels in food and beverage sub-sector companies on the IDX, (2) to apply fuzzy logic analysis based on support and resistance levels with the Fibonacci ratio approach to sub company the food and beverage sector on the IDX, (3) to provide investment decision recommendations in the form of linguistic information on stock price movements in the food and beverage sub-sector companies on the IDX.
The research design used in this study is a case study of the price movements of ten shares in the food and beverage sub-sector companies on the Stock Exchange. Researchers used a research design with secondary data. Furthermore, stock price movement data were analyzed using a merging analysis approach with Fibonacci ratios and fuzzy logic analysis with fuzzy systems so that an investment decision recommen- dation was obtained in the form of linguistic information.
Based on the results of the study showed that technical analysis of stock price move- ments using Fibonacci ratios and fuzzy logic analysis can be used properly. Furthermore, the results of this linguistic information can be utilized by investors who do not own shares and who already have shares, but the results of this data analysis are not absolute and must be adjusted to the conditions in their application.
Pengembangan Bahan Ajar Ilmu Pengetahuan Alam Berbasis Model Learning Cycle 7E untuk Siswa Sekolah Dasar
Authors: Fembriani Fembriani , Hidayat Muhamad Taufik 
Published: November 2019

The purpose of this study is to examine the validity of Natural Science teaching materials for fifth grade of elementary school. The development of this teaching material focused on "Human digestive devices, food and health'' material. The product developed was teaching material based on 7E Learning Cycle learning model (LC7E teaching material). The validity measurements were done by technique of expert validity and content validity. Teaching materials are legitimate if they reach "good" and "very good" categories. The level of validity of LC7E teaching material is on the valid criteria with an average score of 3.8 and a 95% success. The result of the content validity of the 24 questions given by the data obtained an average of r count of 0.575 > r table 0, 514. With that results, the teaching material developed is declared valid.
Markedly Increased Ocular Side Effect Causing Severe Vision Deterioration After Chemotherapy Using New or Investigational Epidermal or Fibroblast Growth Factor Receptor Inhibitors.
Authors: Shin Eunhae , Lim Dong Hui , Han Jisang , Nam Do-Hyun , Park Keunchil , Ahn Myung-Ju , Kang Won Ki , Lee Jeeyun , Ahn Jin-Seok , Lee Se-Hoon , Sun Jong-Mu , Jung Hyun Ae , Chung Tae-Young 
Published: November 2019

Abstract
Background: We sought to describe corneal epithelial changes after using epidermal (EGFR) or fibroblast growth factor receptor (FGFR) inhibitors as chemotherapy and to clarify incidence and prognosis. Materials: Retrospective chart review. Results: Among 6,871 patients and 17 EGFR or FGFR inhibitors, 1,161 patients (16.9%) referred for ophthalmologic examination. In total, 1,145 patients had disease-related or unrelated ocular complications. Among 16 patients with treatment-related ocular complications, three patients had treatment-related radiation retinopathy and one patient showed treatment-related corneal ulcer. Finally the authors identified that, in 12 patients, three EGFR inhibitors and two FGFR inhibitors caused corneal epithelial lesions. Vandetanib, Osimertinib, and ABT-414 caused vortex keratopathy in nine patients, while ASP-5878 and FPA-144 caused epithelial changes resembling corneal dysmaturation in three patients. The mean interval until symptoms appeared was 246 days with vandetanib, 196 days with osimertinib, 30 days with ABT-414, 55 days with ASP-5878, and 70 days with FPA-144. The mean of the lowest logarithm of minimal angle of resolution visual acuity results of the right and left eyes after chemotherapy were 0.338 and 0.413. The incidence rates of epithelial changes were 15.79% with vandetanib, 0.005% with osimertinib, 100% with ABT-414, 50.0% with ASP-5878, and 18.2% with FPA-144. After excluding deceased patients and those who were lost to follow-up or still undergoing treatment, we confirmed the reversibility of corneal lesions after the discontinuation of each agent. Seven patients showed full recovery of their vision and corneal epithelium, while three achieved a partial level of recovery. Although patients diagnosed with glioblastoma used prophylactic topical steroids before and during ABT-414 therapy, all developed vortex keratopathy. Conclusions: EGFR and FGFR inhibitors are chemotherapy agents that could make corneal epithelial changes. Contrary to the low probability of ocular complication with old EGFR drugs, recently introduced EGFR and FGFR agents showed a high incidence of ocular complication with severe vision distortion. Doctors should forewarn patients planning chemotherapy with these agents that decreased visual acuity could develop due to corneal epithelial changes and also reassure them that the condition could be improved after the end of treatment without the use of steroid eye drops.
Endoscopic ultrasound-based transluminal cholecystolithotomy: the retrievable anchor assisted procedure
Authors: Ge Nan , Hu Jinlong , Yang Fei , Yang Fan , Zhang Kai , Sun Siyu 
Published: November 2019

Abstract
Background
Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is gradually emerging as an option among patients with cholecystitis. A stent-bridged endoscopic intervention in the gallbladder (GB) was further introduced. The aim of this study was to assess the effectiveness and safety of the electrocautery-enhanced delivery of a lumen apposing metal stent (ECE-LAMS) and this newly designed retrievable anchor (RA) applied in the transmural cholecystolithotomy.
Method
We retrospectively reviewed consecutive patients undergoing EUS-guided transmural cholecystoscopic therapy. The main outcome measures for the EUS-GBD procedure were technical success and adverse events, which were also compared between the guided assisted group and the RA-assisted group. The main outcome measures for transmural cholecystoscopy after EUS-GBD were the stent indwelling time, clinical success, and adverse events.
Results
A total of 24 (15 female) patients with gallstones received transluminal cholecystolithotomy. The mean age of the patients was 36.08±13.69 years. The success rate of the anchor-assisted group was higher than that of the guidewire-assisted group (92.9% vs. 70%, P=0.07). On an average of 12.25±2.77 (range 8-17) days after the initial GB drainage procedure, 20 patients received per-oral cholecystoscopy via the fistula. A ruptured fistula was found in 2 patients in whom the per-oral cholecystoscopy was applied on the ninth day after EUS-GBD. During the follow-up period (mean 314.2± 213.7 days), no GB stone recurrence or other long-term complications were reported.
Conclusion
We demonstrated that the EUS-assisted per-oral cholecystoscopy technique with ECE-LMAS is an efficient and safe procedure. For the EUS-GBD procedure, a RA could significantly increase the success rate compared with the guidewire.
Experiences from Decentralised Radiological Services in Norway – a rural case study
Authors: Myklebust Aud Mette , Eide Hilde , Ellis Brian , Beattie Rona 
Published: November 2019

Abstract
Background
Implementation of the Norwegian government’s Coordination Reform (2012) aims to decentralise health care services from centralised hospitals to local communities. Radiological services in Norway are mainly organised in hospitals, because of the significant financial and human resource demands engendered by the need for advanced technological equipment, and specialised staff. Some selected conventional x-ray services have been decentralised into rural communities. The purpose of this single case study was to highlight experiences from different stakeholders’ of organiseing decentralised radiological services in a rural area in Norway.
Methods
A qualitative single case study design was adopted, collected data using focus groups with healthcare professionals and managers to obtain stakeholder’s experiences of the radiological services in this rural area. The key emergent themes from the literature, decentralisation, quality, professional roles, organisation and economic consequences – were discussed with each focus group. Thematic analysis was used for analyzing the primary data collected.
Results
Four main themes emerged from the focus groups: 1)organisation, 2)quality and safety, 3)funding of radiological services and 4) cooperation between health care professions and health care levels. It was found that the organisation of decentralised radiological services to rural areas is challenging because of the way health services are structured in Norway. The quality of service was found to be inadequate in some areas because of the superficial level of training given to non-radiographic staff. The experience is that the Norwegian funding system hinders an efficient decentralised health care service. Effective cooperation and responsibility between health care professions and levels was challenging. There needs to be improved co-working by clearly defining roles and responsibilities.
Conclusions
A key recommendation for the organisation of rural radiological service was the development of a satellite link with an acute hospital. Quality of the service could be improved and should be given priority. Structural change to the financial system whereby money follows patients, might also facilitate more patient-centred services across healthcare levels. Improved mutual understanding between rural radiological services and hospital specialists and managers is important for a high quality and consistent radiological service to be delivered across Norway.
Prevalence of asymptomatic malaria parasitaemia following mass testing and treatment in Pakro sub-district of Ghana
Authors: Ndong Ignatius Cheng , Okyere Daniel , Enos Juliana Yartey , Mensah Benedicta Ayiedu , Nyarko Alexander Kwadwo , Abuaku Benjamin , Amambua-Ngwa Alfred , Merle Corinne Simone C. , Koram Kwadwo Ansah , Ahorlu Collins Stephan 
Published: November 2019

Abstract
Background: Global efforts to scale-up malaria control interventions are gaining steam. These include the use of Long-Lasting Insecticide Nets, Indoor Residual Spraying, Intermittent Preventive Treatment and Test, Treat and Track. Despite these, the drive for malaria elimination is far from being realistic in endemic communities in Africa. This is partly due to the fact that asymptomatic parasite carriage, not specifically targeted by most interventions, remains the bedrock that fuels transmission. This has led to mass testing, treatment and tracking (MTTT) as an alternative strategy to target asymptomatic individuals. We report the impact of MTTT on the prevalence of asymptomatic malaria parasitaemia over a one-year period in Ghana, hypothesizing that implementing MTTT could reduce the rate of asymptomatic parasitaemia. Methods: A population of about 5,000 individuals in seven communities in the Pakro sub-district of Ghana participated in this study. A register was developed for each community following a census. MTTT engaged trained community-based health volunteers who conducted house-to-house testing using RDTs every four months and treated positive cases with Artemisinin–based Combination Therapy. Between interventions, community-based management of malaria was implemented for symptomatic cases. Results: MTTT Coverage was 98.8% in July 2017 and 79.3% in July 2018. Of those tested, asymptomatic infection with malaria parasites reduced from 36.3% (1,795/4941) in July 2017 to 32.9% (1,303/3966) in July 2018 (p=0.001). Prevalence of asymptomatic parasitaemia among children under 15 years declined from 52.6% (1,043/1984) in July 2017 to 47.5% (820/1,728) in July 2018 (p=0.002). Implementing MTTT significantly reduced asymptomatic parasitaemia by 24% from July 2017 to July 2018 after adjusting for age, ITN use and axillary temperature (OR=0.76, CI=0.67, 0.85 p≤0.001). Conclusion: This study has demonstrated that implementing MTTT is feasible and could reduce the prevalence of asymptomatic malaria parasitaemia in children under 15 years of age. Furthermore, the use of community-based health volunteers could ensure high coverage at lower cost of implementation.
The utility of a shortened palliative care screening tool to predict death within 12 months – a prospective observational study in two South African hospitals with a high HIV burden
Authors: Raubenheimer Peter , Day Cascia , Abdullah Faried , Manning Katherine , Cupido Clint , Peter Jonny 
Published: November 2019

Abstract
Background: Timely identification of people who are at risk of dying is an important first component of end-of-life care. Clinicians often fail to identify such patients, thus trigger tools have been developed to assist in this process. We aimed to evaluate the performance of a identification tool (based on the Gold Standards FrameworkPrognostic Indicator Guidance) to predict death at 12 months in a population of hospitalised patients in South AfricaMethods: Patients admitted to the acute medical services in two public hospitals in Cape Town, South Africa were enrolled in a prospectiveobservational study. Demographic data were collected from patients and patient notes. Patients were assessed within two days of admission by two trained clinicians who were not the primary care givers, using the identification tool. Outcome mortality data were obtained from patient folders, the hospital electronic patient management system and the Western Cape Provincial death registry which links a unique patient identification number with national death certificate records and system wide electronic recordsResults: 822 patients (median age of 52 years), admitted with a variety of medical conditions were assessed during their admission. 22% of the cohort were HIV-infected. 218 patients were identified using the screening tool as being in the last year of their lives. Mortality in this group was 56% at 12 months, compared with 7% for those not meeting any criteria. The specific indicator component of the tool performed best in predicting death in both HIV-infected and HIV-uninfected patients, with a sensitivity of 74% (68-81%), specificity of 85% (83-88%), a positive predictive value of 56% (49-63%) and a negative predictive value of 93% (91-95%). The hazard ratio of 12-month mortality for those identified vs not was 11.52 (7.87 – 16.9; p < 0.001).Conclusions:The identification tool is suitable for use in hospitals in low-middle income country setting that have both a high communicable and non-communicable disease burden amongst young patients, the majority under age 60.