bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burnout syndrome in university professors and academic staff members: psychometric properties of the Copenhagen Burnout Inventory–Brazilian version
Authors: Rocha Fernanda Ludmilla Rossi , de Jesus Lilian Carla , Marziale Maria Helena Palucci , Henriques Silvia Helena , Marôco João , Campos Juliana Alvares Duarte Bonini 
Published: June 2020

AbstractThe aims of this study were to evaluate the psychometric properties of the Copenhagen Burnout Inventory–Brazilian version (CBI-Br) in a sample of university professors and academic staff members of Brazilian public universities, to estimate the level of burnout syndrome (BS) among these workers, and to assess the associations of BS with demographic and occupational determinants of the syndrome. A total of 676 workers participated in the study. Confirmatory factor analysis results supported a three-factor model with 18 items and an acceptable overall fit. Adequate convergent and discriminant validity of the CBI-Br’s factors were observed, as well as adequate reliability of the instrument for the sample. In conclusion, the results of this study provide evidence of the validity and reliability of the CBI-Br for the measurement of BS in Brazilian university professors and academic staff members. In addition, the CBI-Br may be an important tool for the diagnosis of psychosocial risks related to BS in the academic environment.
Changes in nutritional status of children who lived in temporary shelters in Bhaktapur municipality after the 2015 Nepal earthquake
Authors: Dhoubhadel Bhim Gopal , Raya Ganendra Bhakta , Shrestha Dhruba , Shrestha Raj Kumar , Dhungel Yogendra , Suzuki Motoi , Yasunami Michio , Smith Chris , Ariyoshi Koya , Parry Christopher M. 
Published: June 2020

Abstract
Background
The nutritional status of children may deteriorate after natural disasters such as earthquakes. A 7.8 Richter scale earthquake struck Nepal in 2015 that affected 1.1 million children. Children whose homes were destroyed and had to live in temporary shelters were at risk of malnutrition. With the support of Nagasaki University School of Tropical Medicine and Global Health (TMGH) and Siddhi Memorial Hospital (SMH), we conducted a nutritional survey of under-5 children living in temporary shelters in Bhaktapur Municipality in 2015 immediately after the earthquake and a follow-up survey in 2017.

Results
We found 591 under-5 children living in 22 temporary shelters in 2015. A total of 285 children were followed up and re-assessed in 2017. In a paired analysis (n = 285), the prevalence of underweight children increased from 10.9% in 2015 to 14.0% in 2017 (P < 0.001), stunting increased from 26.7 to 31.9% (P = 0.07), and wasting decreased from 4.2 to 2.5% (P = 0.19).

Conclusions
Children who lived in temporary shelters after the 2015 Nepal earthquake might be at increased risk of a deterioration in nutritional status.
An improved MPPT control strategy based on incremental conductance algorithm
Authors: Shang Liqun , Guo Hangchen , Zhu Weiwei 
Published: June 2020

AbstractPV power production is highly dependent on environmental and weather conditions, such as solar irradiance and ambient temperature. Because of the single control condition and any change in the external environment, the first step response of the converter duty cycle of the traditional MPPT incremental conductance algorithm is not accurate, resulting in misjudgment. To improve the efficiency and economy of PV systems, an improved incremental conductance algorithm of MPPT control strategy is proposed. From the traditional incremental conductance algorithm, this algorithm is simple in structure and can discriminate the instantaneous increment of current, voltage and power when the external environment changes, and so can improve tracking efficiency. MATLAB simulations are carried out under rapidly changing solar radiation level, and the results of the improved and conventional incremental conductance algorithm are compared. The results show that the proposed algorithm can effectively identify the misjudgment and avoid its occurrence. It not only optimizes the system, but also improves the efficiency, response speed and tracking efficiency of the PV system, thus ensuring the stable operation of the power grid.
Endovascular flow-diversion of visceral and renal artery aneurysms using dual-layer braided nitinol carotid stents
Authors: van Veenendaal Penelope , Maingard Julian , Kok Hong Kuan , Ranatunga Dinesh , Buckenham Tim , Chandra Ronil V. , Lee Michael J. , Brooks Duncan Mark , Asadi Hamed 
Published: June 2020

Abstract
Background
Visceral and renal artery aneurysms (VRAAs) are uncommon but are associated with a high mortality rate in the event of rupture. Endovascular treatment is now first line in many centres, but preservation of arterial flow may be difficult in unfavourable anatomy including wide necked aneurysms, parent artery tortuosity and proximity to arterial bifurcations. Endovascular stenting, and in particular flow-diversion, is used in neurovascular intervention to treat intracranial aneurysms but is less often utilised in the treatment of VRAAs. The CASPER stent is a low profile dual-layer braided nitinol stent designed for carotid stenting with embolic protection and flow-diversion properties. We report the novel use of the CASPER stent for the treatment of VRAAs. We present a case series describing the treatment of six patients with VRAAs using the CASPER stent.

Results
Six patients with unruptured VRAAs were treated electively. There were three splenic artery aneurysms and three renalartery aneurysms. Aneurysms were treated with the CASPER stent, with or without loose aneurysm coil packing or liquid embolic depending on size and morphology. All stents were successfully deployed with no immediate or periprocedural complications. Four aneurysms completely occluded after serial imaging follow up with one case requiring repeat CASPER stenting for complete occlusion. In one patient a single aneurysm remained patent at last follow up, A single case was complicated by delated splenic infarction and surgical splenectomy.

Conclusion
Preliminary experience with the CASPER stent suggests it is technically feasible and effective for use in the treatment of VRAAs.
Application of periareolar mastopexy technique for giant phyllodes tumor resection in an adolescent female with breast asymmetry: a case report and literature review
Authors: Hifny Mahmoud A. , A. Mohamed Yousef , R. Asmaa Gaber , Mohamed Mohamed Abdelshafy , Abdelhameid Mahmoud 
Published: June 2020

Abstract
Background
The phyllodes tumors are rare neoplastic disease which exhibits a benign behavior in adolescents female. After resection of a large benign breast tumor, insufficient breast contour may result with nipple areola complex malposition. As symmetry of the breast is psychologically extremely crucial, especially in adolescents, in such cases, an immediate mammoplasty-like breast reduction or mastopexy technique of the affected breast will be necessary to provide symmetry of the bilateral breasts at the initial surgery.

Case presentation
A 16-year-old woman reported rapid enlargement of a large mass in her left breast over 12 months. The physical examination revealed a huge mass that occupied the lower quadrants of her left breast causing expansion of both the overlying skin and the nipple areolar complex. A biopsy was constant with a benign phyllodes tumor. We have applied a periareolar mastopexy technique to allow tumor resection through exposure incision at the lower half of the outer periareolar circular incision. At the same time, we reduced the expanded skin envelope and mobilized the nipple–areola complex to restore breast symmetry.

Conclusion
The periareolar mastopexy approach provides a wide surgical exposure, allows excision of benign giant breast tumor, and simultaneous restoration of the breast shape with favorable aesthetic results and minimal postoperative scarring.
Surgical aspects, violations and outcomes of Wilms tumor—a multicenter study in a resource-limited country
Authors: Elgendy Ahmed , Abouheba Mohamed , Ebeid Abdelmotaleb , Shehata Sherif M. K. , Shehata Sameh 
Published: June 2020

Abstract
Background
Wilms tumor is the commonest malignant renal neoplasm in children. Surgery plays a pivotal role in the management, and evidence-based guidelines for surgical resection have been established by the major international groups. Any deviation from the protocol is considered as a violation. The goal of this study was to evaluate outcomes of the patients with unilateral Wilms tumor treated at a developing country and to analyze surgical violations (SV) and their impact on the prognosis. A retrospective review was conducted for 37 patients who were presented to our hospitals and underwent nephrectomy for WT from January 2016 to December 2018. All participating centers adopt Children’s Oncology Group protocol. The SV were analyzed by logistic regression. Overall survival (OS) and event-free survival (EFS) were estimated by the Kaplan-Meier method.

Results
There were 12 (32.4%), 11 (29.7%), 10 (27%), and 4 (10.8%) stages I, II, III, and IV, respectively. Their median age at time of diagnosis was 3.1 years. Upfront nephrectomy was performed for 30 cases. Six patients had tumor relapse (2 lungs and 4 local recurrences) at a median follow-up of 15.7 months. Out of the relapsed patients, two had unfavorable histology, and regarding their staging, four were stage III, one was stage II, and one was stage IV. Thirty-month OS and EFS were 84.3% and 81.1%, respectively. Twenty-seven SV occurred within 25 patients. Lack or inadequate lymph node sampling represented 74.07% (20/27), intraoperative tumor rupture and spillage accounted for 18.52% (5/27), and unwarranted preoperative biopsy happened in 7.41% (2/27). The SV were not correlated with mortality (p value = 0.381); however, they had a significant impact on the relapse (p value = 0.001). On further analysis; tumor rupture and spillage was a predictor for recurrence reaching a statistical significance (p value = 0.003), whereas the other violations were not.

Conclusions
Favorable outcomes could be achieved by compliance with evidence-based guidelines even in a resource-limited country like ours. Violations were correlated with relapse; however, only tumor rupture and spillage was of statistical significance in multivariate analysis. Failure of lymph node documentation was the main problem encountered, and it should be avoidable in future practice.
Breast Cancer and Major Deviations of Genetic and Gender-related Structures and Function
Authors: Coelingh Bennink Herjan J T , Egberts Jan F M , Mol Jan A , Roes Kit C B , van Diest Paul J 
Published: June 2020

Abstract
We have searched the literature for information on the risk of breast cancer (BC) in relation to gender, breast development, and gonadal function in the following 8 populations: 1) females with the Turner syndrome (45, XO); 2) females and males with congenital hypogonadotropic hypogonadism and the Kallmann syndrome; 3) pure gonadal dysgenesis (PGD) in genotypic and phenotypic females and genotypic males (Swyer syndrome); 4) males with the Klinefelter syndrome (47, XXY); 5) male-to-female transgender individuals; 6) female-to-male transgender individuals; 7) genotypic males, but phenotypic females with the complete androgen insensitivity syndrome, and 8) females with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome (müllerian agenesis).
Based on this search, we have drawn 3 major conclusions. First, the presence of a Y chromosome protects against the development of BC, even when female-size breasts and female-level estrogens are present. Second, without menstrual cycles, BC hardly occurs with an incidence comparable to males. There is a strong correlation between the lifetime number of menstrual cycles and the risk of BC. In our populations the BC risk in genetic females not exposed to progesterone (P4) is very low and comparable to males. Third, BC has been reported only once in genetic females with MRKH syndrome who have normal breasts and ovulating ovaries with normal levels of estrogens and P4. We hypothesize that the oncogenic glycoprotein WNT family member 4 is the link between the genetic cause of MRKH and the absence of BC women with MRKH syndrome.
Prostate Cancer Incidence under Androgen Deprivation: Nationwide Cohort Study in Trans Women Receiving Hormone Treatment
Authors: de Nie Iris , de Blok Christel J M , van der Sluis Tim M , Barbé Ellis , Pigot Garry L S , Wiepjes Chantal M , Nota Nienke M , van Mello Norah M , Valkenburg Noelle E , Huirne Judith , Gooren Louis J G , van Moorselaar R Jeroen A , Dreijerink Koen M A , den Heijer Martin 
Published: June 2020

Abstract

Context
Trans women (male sex assigned at birth, female gender identity) mostly use antiandrogens combined with estrogens and can subsequently undergo vaginoplasty including orchiectomy. Because the prostate remains in situ after this procedure, trans women are still at risk for prostate cancer.

Objective
To assess the incidence of prostate cancer in trans women using hormone treatment.

Design
In this nationwide retrospective cohort study, data of participants were linked to the Dutch national pathology database and to Statistics Netherlands to obtain data on prostate cancer diagnosis and mortality.

Setting
Gender identity clinic.

Participants
Trans women who visited our clinic between 1972 and 2016 and received hormone treatment were included.

Main Outcome Measures
Standardized incidence ratios (SIRs) were calculated using the number of observed prostate cancer cases in our cohort and the number of expected cases based on age-specific incidence numbers from the Netherlands Comprehensive Cancer Organization.

Results
The study population consisted of 2281 trans women with a median follow-up time of 14 years (interquartile range 7-24), and a total follow-up time of 37 117 years. Six prostate cancer cases were identified after a median 17 years of hormone treatment. This resulted in a lower prostate cancer risk in trans women than in Dutch reference males (SIR 0.20, 95% confidence interval 0.08-0.42).

Conclusions
Trans women receiving androgen deprivation therapy and estrogens have a substantially lower risk for prostate cancer than the general male population. Our results support the hypothesis that androgen deprivation has a preventive effect on the initiation and development of prostate cancer.
Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?
Authors: Yu Jie , Berga Sarah L , Zou Wei , Rajakumar Augustine , Man Mingfei , Sidell Neil , Taylor Robert N 
Published: June 2020

Abstract

Context
Implantation is a reproductive bottleneck in women, regulated by fluctuations in ovarian steroid hormone concentrations. However, other nuclear receptor ligands are modifiers of endometrial differentiation leading to successful pregnancy. In the present study we analyzed the effects of peroxisome-proliferator-activated receptor β/δ (PPARβ/δ) activation on established cellular biomarkers of human endometrial differentiation (decidualization).

Objective
The objective of this work is to test the effects of PPARβ/δ ligation on human endometrial cell differentiation.

Design
Isolated primary human endometrial stromal cells (ESCs) were treated with synthetic (GW0742) or natural (all trans-retinoic acid, RA) ligands of PPARβ/δ, and also with receptor antagonists (GSK0660, PT-S58, and ST247) in the absence or presence of decidualizing hormones (10 nM estradiol, 100 nM progesterone, and 0.5 mM dibutyryl cAMP [3′,5′-cyclic adenosine 5′-monophosphate]). In some cases interleukin (IL)-1β was used as an inflammatory stimulus. Time course and dose-response relationships were evaluated to determine effects on panels of well characterized in vitro biomarkers of decidualization.

Results
PPARβ/δ, along with estrogen receptor α (ERα) and PR-A and PR-B, were expressed in human endometrial tissue and isolated ESCs. GW0742 treatment enhanced hormone-mediated ESC decidualization in vitro as manifested by upregulation of prolactin, insulin-like growth factor-binding protein 1, IL-11, and vascular endothelial growth factor (VEGF) secretion and also increased expression of ERα, PR-A and PR-B, and connexin 43 (Cx43). RA treatment also increased VEGF, ERα, PR-A, and PR-B and an active, nonphosphorylated isoform of Cx43. IL-1β and PPARβ/δ antagonists inhibited biomarkers of endometrial differentiation.

Conclusion
Ligands that activate PPARβ/δ augment the in vitro expression of biomarkers of ESC decidualization. By contrast, PPARβ/δ antagonists impaired decidualization markers. Drugs activating these receptors may have therapeutic benefits for embryonic implantation.
Phenotypic Profiling in Subjects Heterozygous for 1 of 2 Rare Variants in the Hypophosphatasia Gene (ALPL)
Authors: Tilden Daniel R , Sheehan Jonathan H , Newman John H , Meiler Jens , Capra John A , Ramirez Andrea , Simmons Jill , Dahir Kathryn 
Published: June 2020

Abstract

Context
Hypophosphatasia (HPP) is a syndrome marked by low serum alkaline phosphatase (AlkP) activity as well as musculoskeletal and/or dental disease. While the majority of subjects with HPP carry a pathogenic variant in the ALPL gene or its regulatory regions, individual pathogenic variants are often not tightly correlated with clinical symptomatology. We sought to better understand the genotype/phenotype correlation in HPP by examining the clinical and biochemical data of 37 subjects with 2 rare variants in ALPL.

Methods
Through BioVU, a DNA biobank that pairs individuals’ genetic information with their de-identified medical records, we identified subjects with 2 rare variants with distinct reported clinical phenotypes (p.D294A and p.T273M). We then performed a manual review of these subjects’ de-identified medical records along with computational modeling of protein structure to construct a genetic, biochemical and clinical phenotype for each subject and variant.

Results
Twenty subjects with the p.D294A variant and 17 with the p.T273M variant had sufficient data for analysis. Among subjects in our cohort with the p.D294A variant, 6 (30.0%) had both clinical bone disease and serum AlkP activity below 40 IU/L while 4 subjects (23.5%) with the p.T273M variant met the same criteria despite the distinct clinical phenotypes of these variants.

Conclusions
Given the loose genotype/phenotype correlation in HPP seen in our cohort, clinical context is crucial for the interpretation of genetic test results to guide clinical care in this population. Otherwise, over- or under-diagnosis may occur, resulting in misidentification of those who may benefit from additional screening and perhaps pharmacologic intervention.
Contribuições do PIBIC/CNPq para a constituição do habitus de pesquisador
Authors: Moura Daiana De Nez , Cecchetti Elcio , Bernardi Luci Teresinha Marchiori dos Santos 
Published: June 2020

Esse trabalho versa sobre o Programa Institucional de Bolsas de Iniciação Científica (PIBIC), mantido e fomentado pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). O estudo foi desenvolvido na Universidade Comunitária da Região de Chapecó (Unochapecó), com o objetivo de analisar se o PIBIC/CNPq influenciou os bolsistas egressos da IES a permanecerem no campo científico e a internalizarem um habitus de pesquisador. A coleta de dados foi realizada através de questionário eletrônico aos bolsistas ingressantes no PIBIC/CNPq no período de 2010 a 2015 e que finalizaram as atividades no Programa até 2017. O tratamento dos dados foi realizado com base na Análise de Conteúdo, ancorada epistemologicamente no pensamento de Pierre Bourdieu. Os resultados apontaram que os beneficiados do PIBIC/CNPq adquiriram um montante de capital científico que favoreceu a entrada e permanência no campo científico. Assim, através das atividades científicas desenvolvidas durante a vigência da bolsa - participação e publicação em eventos, acompanhamento de um professor-orientador, auxílio na escolha profissional e estímulo para continuação dos estudos em nível de pós-graduação – tais estudantes constituíram um habitus de pesquisador.
Projeto Vale Sonhar como instrumento de educação sexual nas escolas públicas de São Paulo
Authors: Antoniassi Patrícia Vieira , Miranda Meiri Aparecida Gurgel de Campos 
Published: June 2020

O Projeto Vale Sonhar foi inserido no Currículo do Estado de São Paulo em 2008 e teve suas atividades incluídas no material didático de Biologia de primeiro ano do ensino médio. Este artigo tem como objetivo analisar a contribuição deste material para a prática de Educação Sexual Emancipatória na Educação Básica, a partir da realização das oficinas do kit educativo, com uma turma de 1º ano do Ensino Médio, durante as aulas de Biologia. Em seguida, pretende-se apontar limites e propor alterações como forma de superar as dificuldades encontradas e ampliar o potencial formativo desta ação didática. O Projeto Vale Sonhar constituía um importante espaço curricular destinado à temática, no entanto, apresenta limitações como o longo tempo necessário para sua execução, que impacta na diminuição do aspecto lúdico e inviabilidade em um contexto de currículos extensos e poucas aulas semanais de Biologia. Percebemos a importância da inserção das dimensões psicológicas e socioculturais nas oficinas, questionamos a ausência de menção às Infecções Sexualmente Transmissíveis (IST) e apontamos para alguns problemas nas atividades propostas. Neste sentido, sugerimos algumas alterações nas oficinas, buscando trabalhar, além da prevenção da gravidez, temas que não eram abordados neste material, como elaboração do projeto de vida, a prevenção de IST, diversidade e violência sexual. Esperamos, assim, oferecer recursos para que os docentes de Biologia incluam em suas aulas o Projeto Vale Sonhar, trabalhando a Educação Sexual com seus alunos de forma integral, contemplando também aspectos psicológicos e socioculturais e a reflexão sobre o projeto de vida.
Indeksasi Jurnal di Lingkungan Universitas Lancang Kuning
Authors: Sudiar Nining , Latiar Hadira 
Published: June 2020

Penelitian ini bertujuan untuk menganalisis perkembangan indeksasi jurnal yang ada di Universitas Lancang Kuning dengan cara menghitung jenis lembaga pengindeks dan menghitung jumlah indeksasi yang pada setiap jurnal. Metode penelitian yang digunakan adalah deskriptif kuantitatif dengan pendekatan kepustakaan melalui penelusuran pada URL jurnal Unilak. Hasil penelitian menunjukan bahwa ada 38 jenis pengindeks dengan jumlah 143 lembaga pengindeks yang terdapat pada 16 jurnal. Lima peringkat lembaga pengindeks terbanyak, pertama, Crossref dan Google Scholar yaitu 16 jurnal atau 18,83%, kedua Garuda sebanyak 11 jurnal atau 7,69%, ketiga OCLC WorldCat sebanyak 10 jurnal atau 6,99 %, keempat ada pada Bielefels Academic Search Engine (BASE) yaitu 9 jurnal atau 6,29 % dan yang kelima ada pada Science and Technology Index (Sinta) dengan jumlah 8 jurnal atau 5, 59%. Dapat disimpulkan bahwa lembaga pengindeks yang paling banyak dimiliki jurnal Unilak adalah lembaga pengindeks bereputasi rendah yaitu 95,11 %, lembaga pengindeks bereputasi sedang 4,89% dan belum memiliki lembaga pengindeks bereputasi tinggi seperti Scopus dan Thomson.