bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTS OF PHENOLIC COMPOUNDS EXTRACTED FROM SALVIA FRIGIDA ON INDUCED HYPERURICEMIA IN MICE
Authors: MUHAMMAD ABDULHUSSEIN AL-DABBAGH  , SHIHAB ABDULRAHMAN SHIHAB  , ENAS JAWAD KADHIM  
Published: October 2019

Objective: The aim of this study was to investigate effects of phenolic compounds rich fraction extracted from aerial parts of Salvia frigida on serum uric acid (SUA) and xanthine oxidase (XOD) in hyperuricemic mice model.
Methods: A total of 40 albino male mice were equally divided into four groups. The blank group was given vehicles only. The model of hyperuricemia was induced by single intraperitoneal injection of UA (250 mg/kg). S. frigida group was pretreated orally with phenolic compounds rich fraction (300 mg/kg) for 6 days and one final oral dose was given directly after the UA injection on the 7th day as an acute treatment and the same was applied to allopurinol (20 mg/kg) which served as a positive control. 1 h later blood was withdrawn to be tested for SUA, XOD, and creatinine levels. Furthermore, the body weights were daily documented before each administration.
Results: The results revealed a highly comparable significant reduction in SUA and XOD in both S. frigida and allopurinol groups without significantly affecting serum creatinine compared to model group, also both modestly decreased the body weights of mice.
Conclusion: S. frigida significantly reduces SUA in the hyperuricemic model and may also have a promising effect on weight management.
STUDY ON THE CHEMICAL CONSTITUENTS OF THE ESSENTIAL OIL FROM NYCTANTHES ARBOR-TRISTIS AND ITS MOLECULAR DOCKING STUDIES
Authors: KARTHICK V  , VENKATAREDDY G  , DHARANI J  , RAVI S  
Published: October 2019

Objectives: The objectives of this study were to determine the chemical composition of the essential oil obtained from the flowers of Nyctanthes arbor-tristis (NAT) and to carryout molecular docking studies against three bacterial proteins to study the mechanism of the antibacterial activity.
Methods: The essential oil was obtained from the flowers of NAT by hydrodistillation and the chemical composition was determined by gas chromatography–mass spectrometry analysis. Docking study was carried out for 14 compounds identified from NAT against three bacterial proteins 1UAG, 3TYE, and 3UDI.
Results: Fourteen compounds were identified in the essential oil. 1-octanol (74.81%) is the predominant compound followed by phytol (6.80%), bis (2-ethylhexyl) phthalate (5.88%), and eucarvone (4.23%). Many compounds are similar to that of the essential oil from jasmine. Among the 14 compounds identified, 7,9-di-tert-butyl-1-oxaspiro (4,5) deca-6,9-diene-2,8-dione interacted well with 1UAG and 3TYE and showed binding scores of −8.9 and −7.2 K Cal/mol, respectively, involving hydrophilic and hydrophobic interactions. With the protein 3UDI, the compound eucarvone exhibited a binding score of −7.1 K Cal/mol.
Conclusion: The similarities between the essential oil constituents of flowers the two plants NAT and jasmine. Therefore, it could be concluded that NAT flowers of Coimbatore are a good source of fragrance for cosmetic industry and as an antibacterial agent.
DFT Calculations and In Silico Studies on the Schiff base derivatives with Antibacterial Activities
Authors: P Arthi 
Published: October 2019

Abstract
The heterocyclic Schiff bases (N1Z,N4Z)-N1,N4-bis(3,4-methoxyphenyl)methylidene) benzene-1,4-diamine (1), (N1Z,N4Z)-N1,N4-bis(4-bromobenzylidene)benzene-1,4-diamine (2) and (N1Z,N4Z)-N1,N4-bis(furan-2-ylmethyliden)benzene-1,4-diamine (1) were synthesized by the reported procedure. The molecular structure of the compounds (1‒3) was characterized by FT‒IR and 1H NMR. The bond length, bond angle and HOMO‒LUMO energy gap were calculated out by DFT calculations. The synthesized heterocyclic compounds (1‒3) were screened for their antibacterial activity against Staphylococcus aureus and Escherichia coli. The compound 3 displays superior antibacterial activity compared to standard drug Streptomycin. All the compounds significantly interact with antibacterial protein beta-ketoacyl-acp synthase III and anticancer protein c-Kit tyrosine kinase via p–p, σ–p, hydrogen bonding, electrostatic and van der Waals interactions.
A A VALIDATED REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-CHARGED AEROSOL DETECTOR TECHNIQUE FOR THE SIMULTANEOUS ESTIMATION OF SITAGLIPTIN AND ERTUGLIFLOZIN IN PURE AND PHARMACEUTICAL DOSAGE FORMS
Authors: ANJANEYULU REDDY B  , RADHAKRISHNANAND P  , IRSHAD ALAM MD  , RAVI KIRAN P  
Published: October 2019

Objective: The main objective of the present work is to develop and validate a selective reverse-phase (RP) high-performance liquid (HPLC)-charged aerosol detection technique for the quantitation of the sitagliptin and ertugliflozin in dosage form to attain high degree of sensitivity.
Materials and Methods: In present HPLC technique, separation of drugs was achieved on Phenomenex C18 column (250×4.6 mm, 5 μ) with a mobile phase composition of phosphate buffer (pH – 5.8), acetonitrile, and methanol in the proportion of 40:40:20%V/V. 1 ml/min flow rate and 256 nm wavelength detection were maintained for the elution of drugs in the chromatographic system. The retaining time of sitagliptin and ertugliflozin in column was found to be 4.2 and 2.4 min, respectively.
Results: The projected technique was successfully applied for the quantitation of sitagliptin and ertugliflozin as a single combined mixture. The linearity statistics for calibration curves shown a good linearity in the concentration range of 0.3125–10 μg/ml for sitagliptin and 0.0625–2.5 μg/ml for ertugliflozin. The average values of regression coefficient, slope, and intercept were 0.9998, 8688.2, and 1977.6 for sitagliptin and 0.9996, 33602, and 1852.6 for ertugliflozin. The technique was validated as per the International Council for Harmonization guidelines. The limit of detection and limit of quantification findings were 0.082 and 0.247 μg/ml for sitagliptin and 0.04 and 0.12 μg/ml for ertugliflozin.
Conclusion: The developed and validated RP-HPLC-charged aerosol detector technique of sitagliptin and ertugliflozin in dosage form showed that the method was accurate and selective with high degree of sensitivity.
CULTURA AUTORITÁRIA, ULTRACONSERVADORISMO, FUNDAMENTALISMO RELIGIOSO E O CONTROLE IDEOLÓGICO DA EDUCAÇÃO BÁSICA PÚBLICA
Authors: Frigotto Gaudêncio , Ferreira Sonia Maria 
Published: October 2019

Este artigo busca analisar as determinações histórico-culturais que impedem que a maioria dosjovens brasileiros tenha o direito social e subjetivo do Ensino Médio. No primeiro ponto, situamos o que Karel Kosik denominou de “metafísica da cultura” para designar a concepção da realidade social como soma de fatores e não como uma estrutura de relações sociais de poder. Essa visão ahistórica, do liberalismo conservador nascente transforma-se em ultraconservadora no contexto da crise estrutural do capital. Na sequência, buscamos analisar a cultura autoritária e ultraconservadora na especificidade de nossa formação social e que, no presente, conjuga-se com o fundamentalismo religioso.
Problems in Visualizing and Validating History: A Discourse on Rani by Jaishree Misra
Authors: Singh Kavita 
Published: October 2019

Our Indian education system is such that we are taught a lot about history, long fought battles, wars, invaders and kings and rulers who died when and how. In broader sense, history does not only about dates and battles, it associates and intersperses our past and present with social, cultural, religious and traditional discourses. Our history spanning over thousand years guide our present and future. Indian writers have given their thoughts flying colors making our history unbelievably great. They get inspired from our enormously vast past incidents and express them according to their views and idea. There is no particular parameter which may define the history as fiction. Indian mythological epics like Ramayana and Mahabharata have been described and redefined in numerous different ways. India and Indian people have suffered a lot when British army ruled us for more than 200 years. There were many brave patriots who fought for our independence. One of such fighters is Rani Lakshmi Bai. This paper explores her life validating history through the novel, Rani. This novel is written by Jaishree Misra. Indian writers have explored the life and bravery of this amazingly courageous woman who redefined the womanhood and valor in her own way making a wave for the revolutionary fight for independence.
Player Load and Metabolic Power Dynamics as Load Quantifiers in Soccer
Authors: Reche-Soto Pedro , Cardona-Nieto Donaldo , Diaz-Suarez Arturo , Bastida-Castillo Alejandro , Gomez-Carmona Carlos , Garcia-Rubio Javier , Pino-Ortega Jose 
Published: October 2019

Abstract
There has recently been an increase in quantification and objective analysis of soccer performance due to improvements in technology using load indexes such as Player Load (PL) and Metabolic Power (MP). The objectives of this study were: (1) to describe the performance of PL and MP in competition according to the specific role, match‐to‐ match variation, periods of play, game location and match status according to game periods, and (2) to analyze the relationship between both indexes. Twenty‐one national‐level soccer players were distributed in the following specific positional roles: external defenders (ED) (n = 4), central defenders (CD) (n = 4), midfielders (M) (n = 5), external midfielders (EM) (n = 4) and attackers (A) (n = 4). A total of 12 matches played by a Spanish Third Division team during the 2016/2017 season were analyzed. WIMU PROTM inertial devices (RealTrack System, Almeria, Spain) were used for recording the data. The main results were: (1) a performance reduction in both variables over the course of match time, (2) significant differences in both variables based on the specific position, (3) differences in physical demands during the season matches, (4) winning during a game period and the condition of being the visitor team provoked higher demands, and (5) a high correlation between both variables in soccer. In conclusion, different contextual variables influence the external load demands; both indexes are related so they could be used for external load quantification, and it is necessary to analyze physical demands of the competition for a specific and individualized load design in training sessions.
No Pain, No Gain? Prevalence, Location, Context, and Coping Strategies with Regard to Pain Among Young German Elite Basketball Players
Authors: Schneider Sven , Sauer Johannes , Berrsche Gregor , Schmitt Holger 
Published: October 2019

Abstract
Pain among young athletes requires special attention given that symptoms occur during the ongoing development of the conditional, and in particular, the motor capacities, and while the musculoskeletal system is in a continuous process of growth. The purpose of this study was to evaluate prevalence, location, context, and coping strategies regarding pain among young athletes. We chose survey data of young elite athletes from the highest level national basketball leagues in Germany, as this meant that health implications may be observed earlier and in a more pronounced manner. The German ‘Adolescents’ and Children’s Health in Elite Basketball study’ (ACHE study), a quantitative survey, was conducted between April and June 2016. Analyses were based on elite basketball players between 13 and 19 years of age from 46 German teams (n = 182). Constant, and to some extent severe pain, was part of daily life of young elite basketball players: eight out of ten players in the highest German leagues suffered from pain at the time of the survey. Knee, leg, and back pain occurred most frequently. For most players, occasional or frequent consumption of analgesics was the norm, in some cases these were also taken “prophylactically”. The consumption of multiple pharmaceutical substances, especially of cyclooxygenase inhibitors such as ibuprofen and diclofenac, is widespread among adolescent elite basketball players. Physicians involved in treating these athletes should address pain and its management preemptively. Coaches, sporting organizations and parents should be involved in this process from an early stage.
Trends of Goal Scoring Patterns in Soccer: A Retrospective Analysis of Five Successive FIFA World Cup Tournaments
Authors: Kubayi Alliance , Toriola Abel 
Published: October 2019

Abstract
This study analysed the 795 goals scored during a total of 320 matches played in five successive FIFA World Cup tournaments (1998–2014). Data were obtained through YouTube videos and analysed by means of Longomatch software. The variables analysed included the number of goals scored per half (45‐min period), per 15‐min period, and per 30‐min period of extra time, goal scoring zones, goals scored by substitutes, types of goals scored, and goals scored according to the playing position. With regard to 15‐min period analysis, most goals were scored between the 76th and 90th minutes (24.7%) of the game in all five World Cup competitions. Chi‐square analyses showed no significant (p > 0.05) differences in the frequency of goal scoring patterns per 45‐min and 15‐min periods in the five World Cup tournaments. Most goals were scored from inside the goal (23.8%) and penalty (14.6%) areas. The greatest number of goals was scored by strikers (54.2%), followed by midfielders (33.3%) and defenders (2.3%). These findings provide practical implications for improving goal‐scoring performance in soccer.
Effect of the French Contrast Method on Explosive Strength and Kinematic Parameters of the Triple Jump Among Female College Athletes
Authors: Elbadry Naglaa , Hamza Amr , Pietraszewski Przemyslaw , Alexe Dan Iulian , Lupu Gabriel 
Published: October 2019

Abstract
There are resistance training methods that result in strength, others that enhance hypertrophy and others that stimulate power. The training modality of contrast provides all of these benefits in one session. The concept of French Contrast training is based on a combination of complex and contrast methods. The idea is to use four exercises to induce physiological responses of the athlete and train along the force-speed curve. The primary purpose of the study was to investigate the impact of the French Contrast Method on explosive strength and kinematic parameters of the triple jump among female college athletes. Ten female college athletes from the Helwan University’s track and field team participated in this study. Participants were assessed before and after an 8-week training program for upper and lower body explosive strength. No significant differences were observed in anthropometric characteristics. Explosive strength variables (Sargent jump test, countermovement jump, and seated medicine ball throw) increased significantly and kinematic parameters of the triple jump improved. The results indicated that eight weeks of the French Contrast training can improve both explosive strength and kinematic parameters of the triple jump.
Resources in shaping the efficiency of dynamic capabilities of Polish enterprises
Authors: Tsifert Sh. , Kshakevich K. 
Published: October 2019

The dynamic capabilities, representing the organization’s competence to integrate, create and reconfigure internal and external competencies to ensure compliance with constantly changing environmental conditions, allow the organization to achieve a competitive advantage in the long term. The assumption of the background about the importance of dynamic capabilities for understanding the phenomenon of competition raises the question of the variables, affecting the effectiveness of the processes of formation of dynamic capabilities.The aim of this paper is discussion of the results of studies on the impact of resources on the effectiveness of the processes of formation of dynamic capabilities of Polish enterprises. The nature and essence of dynamic abilities of enterprises have been characterized in the article, the value of resources in the processes of formation of dynamic abilities of Polish enterprises has been noted, which subsequently allowed to formulate conclusions about the relationship between resources and efficiency of processes of formation of dynamic abilities of Polish enterprises have been formulated. The results of the research resources in the processes of formation of dynamic capabilities of Polish enterprises, presented in the paper, are fragment of the research project, whose goal is to develop a paradigm concept of dynamic capabilities from the perspective of strategic management, identification and analysis of dynamic capabilities of Polish enterprises.According to respondents in the process of questioning, sources of efficiency should be sought in external variables (customer loyalty, market share, sales growth), but not in internal variables (employment growth). Such a state, indicating the orientation of the organization outward, should be considered correct from the point of view of the logic of the dominant ways of constructing a strategy, since it indicates an understanding of the needs of the environment, while dynamically comparing with the expectations of this environment and the resources available to the organization.
Formation of competitive advantages of Russian transnational corporations in the context of globalization
Authors: Mozgovoy A. 
Published: October 2019

The general issues of competitiveness of transnational corporations have been considered. Research of the problem of competitiveness of Russian transnational corporations on the world market and the formation of their competitive advantages for sustainable development in a globalized economy has been сonducted. The author’s interpretation of the concept of “enterprise competitiveness” has been proposed.In a global liberalized economy, transnational corporations have the opportunity to influence geopolitical issues in international trade and employment, as well as dictate their own rules. The constant increase in the level of competitiveness of a small group of transnational corporations has been noted in the article, the format of competition in industry and regional markets is often oligopolistic. Building a true global strategy for the development of transnational corporations and obtaining a competitive advantage by them is impossible without sufficient knowledge of current trends in globalization: globalization of the market, globalization of costs, globalization of competition, globalization of government policies. The methods of obtaining competitive advantages of transnational corporations have been adduced and сharacterized.For Russian transnational corporations, the issue of their competitiveness is very acute in the markets of rapidly turning goods or in the markets of new technologies. Factors, hindering the growth of the competitiveness of Russian corporations: incorrect corporate policies, leading to inefficiency of personnel motivation, corporate culture, inconsistency with international standards, incorrect alignment of the global strategy, lack of reciprocity principles and correct negotiation. This creates a negative image of the company, which affects its position, and subsequently its competitiveness. Competitiveness is one of the most important factors for ensuring the sustainable development of the economy of Russian corporations. The criteria for assessing sustainability, the corporations should meet have been suggested.
Online sales funnel as an analytical tool for business efficiency management
Authors: Vasilieva E. , Loseva V. 
Published: October 2019

The possibilities of online sales strategy analysis based on unit-economy metrics (Unit Economics is a new economic modeling method used to determine the effectiveness of a digital business model by assessing the profitability of a product unit or a single customer), as well as on the theory of restrictions, have been shown. The peculiarities of settings of problems on monitoring the process of attracting customers to the electronic resource of a company, and their support up to conclusion of commercial transaction (product sale) have been revealed. A scenarios matrix for promoting information about a product, a brand, or a service using various communication channels has been compiled.Among various strategies of a sales funnel management the following three main strategies have been highlighted: the strategy of a proportional expansion (when increasing a traffic at the entrance of a funnel, which gives a large conversion, the funnel expands at all next stages, and the output result is increased); the strategy of stretching (increasing of a conversion at each level results in the output increasing), and the strategy of a key level (this strategy demands to determine the level of the funnel, which limits the entire system, and to apply efforts to improve conversion indicators at this special level). A methodology for constructing and analyzing the product funnel using unit-economy metrics has been adduced. The peculiarities of development of strategies for sales funnel using the critical-chain method (Critical Chain Management, CPM) and method of Theory of Constraints (TOC) have been highlighted, when the company’s results depend on the interacting elements of the system, that create the constraints. A method of searching bottlenecks in the sales funnel has been proposed, which consists in a consistent assessment of the impact on the profits of each of its five basic metrics, for each of which there are special development tools, allowing one to find points of rapid profit growth. Scenario analysis of sales funnel using unit metrics has been сarried out.
Competitive strategies of differentiation and cost minimization
Authors: Mikhailov O. 
Published: October 2019

The strategies of differentiation and cost minimization are oriented on reception of competitive advances in the broad range of industries/branches, that allows companies to achieve effective exceed in the industry-average indicators. Using the both strategies can bring the synergetic effect in competition of the subjects and objects. These strategies can reinforce each other and the competitive advances of the company. Strategies of cost minimization and differentiation can coexist and compete. Cost leadership strategy focuses on getting advantages by reducing cost below analogies of all competitors. It is unsufficient the single of cost minimization in the international competing, it is necessary the complex and creative decision of the compound problems, associated with differentiation of products and services.Product differentiation is a business strategy, whereby firms attempt to gain a competitive advantage by increasing the perceived value of their products/services relative to perceived value the other products/services firms; with recording dissatisfied inquiring the customers. Especially distinctive characteristics, properties, attributes of products or services can be one or more-the main thing that they were really important, more useful and valuable for buyers. The differentiation can create on the basis the timing of product introduction, product customization, the best joining the product and services or simultaneously combination of these advantages. Product differentiation is ultimately an expression of the creativity of individuals and groups within the firm. It is limited not only by opportunities, than exist, or than can be created, in particular industry, but by the willingness and ability of firms to creatively explore ways to take advantage of those opportunities.The willingness of consumers to pay more suggests, that important perceptual bases of product differentiation exist. Successful implementation of these strategies can increase consumer sensations/perceptions of the greater value of products/ services and contribute to the expansion of their exports and strengthen the competitiveness of the company in the global economy. The ideal strategy-building process is to achieve a high level of commitment of employees and consumers around a high-quality strategy and the best ways to implement it.