bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthroscopic Side-to-Side Suture Repair for Full-Thickness Transtendinous Supraspinatus Rotator Cuff Tear
Authors: Steuer Fritz , Marcaccio Stephen , McMahon Sophia , Dalton Jonathan F. , Fox Michael , Lin Albert 
Published: December 2024

Background: Full-thickness, transtendinous supraspinatus tears involve a significant portion of the remnant tendon that remains attached to the greater tuberosity footprint. This tear type often leaves insufficient medial tissue for tension-free footprint restoration with traditional repair techniques. In these clinical scenarios, side-to-side suture repair is an effective repair technique. Indications: Indications for this procedure include an acute mechanism of injury, sufficient remnant tendon left on the greater tuberosity, and a medial tear location such that primary repair of the medial tendon would not result in overtensioning of the repair. Technique Description: Following diagnostic arthroscopy, 2 suture tapes are passed through the medial and lateral portion of the tendon surface in a simple side-to-side fashion. Two FiberLink sutures (Arthrex) are then placed in luggage tag fashion, in between the side-to-side sutures within the myotendinous portion of the tear. The suture tapes are then tied in an arthroscopic fashion, completing the side-to-side repair. The looped sutures are then secured through a 4.75-mm BioComposite SwiveLock lateral row anchor (Arthrex) as an added reinforcement to prevent medial retraction of the myotendinous portion of the tear, creating a tension-free environment for optimal tear healing. Results: Available literature suggests that the side-to-side repair technique in patients with transtendinous supraspinatus rotator cuff tears yields excellent outcomes equivalent to that of tendon-to-bone double-row suture anchor repair for conventional tendon to bone type tears. This surgical technique reduces risk of overtensioning the repair and optimizes the healing environment in this rare clinical scenario. Discussion/Conclusion: Side-to-side suture repair for full-thickness transtendinous supraspinatus tears is an effective treatment for patients with this uncommon presentation. When healthy tendon is present, a robust repair can be achieved with excellent outcomes and low rates of surgical complications. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Efficacy and experience of system constellations in virtual reality (VR): study protocol for a randomized controlled feasibility study
Authors: van Bebber Tobias , Tappe Eik-Henning , Druyen Thomas , Kleve Heiko , Rüsen Tom , Hunger-Schoppe Christina 
Published: December 2024

Abstract
Background
Though evidence-based research about system constellations (SCs) appears marginal, it is applied in many psychiatric, psychological, and psychotherapeutic institutions as well as in different contexts of organizational counseling. To date, only one randomized controlled trial (RCT) has been conducted to assess the short- to long-term efficacy of SCs, which entail clients meeting at the same location in person. This study is to investigate the feasibility of a RCT investigating SCs in virtual reality (VR), and to calculate the number of clients needed for a confirmatory RCT.

Design
We will perform a prospective, monocentric, parallel-group, feasibility RCT with subsequent intervention. A total of 128 clients of 3-day group-based SC-VR seminars will be randomized to either the intervention group (IG; n = 64) or wait-list group (WLG; n = 64), which receives SCs in VR after 4 months. Feasibility and acceptability of the (1) research methodology and (2) intervention as well as the (3) estimation of effect sizes will be assessed using qualitative and quantitative data. Based on the model of a general mental health, the proposed primary outcome includes the SC-VR adherence, and the proposed secondary outcomes refer to psychological functioning (OQ-45.2), social system functioning (EXIS), psychological distress (FEP-2), motivational incongruence (INK-SF), and goal attainment (GAS). We plan to investigate the short-term efficacy at 2-week and 4-month follow-up within the RCT design (n = 128), and mid-term efficacy at 8- and 12-month follow-up for the intervention group (n = 64).

Discussion
The study is expected to be the first study on the feasibility of SC-VR. We will reflect on successfully implemented study procedures, and we will provide recommendations for changes considering the design, rationale, analyses, and interpretation of the study results where they became necessary. The discussion will conclude with an evaluation whether a confirmatory RCT on SC-VR is worth the investment of future resources, including the calculated number of clients needed based on the efficacy trends derived from this feasibility study.

Trial registration
ClinicalTrials.gov: ID = N CT05557890; date of registration: September 23, 2022; https://clinicaltrials.gov/ct2/show/NCT05557890.
Detection of Helicobacter pylori using non-invasive techniques in Duhok City, Iraq
Authors: Polse Reem , Hasan Haliz , Khalid Haval , Mero Wijdan 
Published: December 2024

Abstract
Background
Helicobacter pylori infection affects over 50% of the global population. Individuals acquire this infection in early childhood that persists throughout life if not treated. The degree of the outbreak severity varied from one region to another, causing long-term clinical consequences such as gastritis, peptic ulcer disease, and cancer of the stomach. The primary objective of this investigation was to estimate the prevalence of Helicobacter pylori among the population in Duhok City via the implementation of non-invasive methods.

Methods
From January 2021 to December 2022, 2313 cases were studied using ELISA assays for immunoglobulins, IgG, IgM, and IgA, a stool antigen test (SAT), and a urea breath test (UBT) to identify Helicobacter pylori.

Results
Among 2313 patients of both genders, 61.7% (1427/2313) were females and 38.3% (886/2313) were males. The prevalence of H. pylori infection was 35.28% among them, with a high significant difference in infection rate in females than males (60.78% vs 39.22%), and among various ages with the highest being at ages of 31 to 40 years. The serological and the SAT tests are commonly used diagnostic tests that yield the most significant number of positive results. Furthermore, a notable correlation was observed between the prevalence of infection and age, especially for IgA and UBT where males exhibited higher significant levels than females; moreover, for UBT, highly significant variations were observed among ages also.

Conclusions
Over half of the performed tests detected H. pylori antibodies with the peak at 49.3% for the IgG test, indicating the body elicits an immune response against this bacterium. Both gender and age were linked to this infection. For more clarification of the prevalence of H. pylori, we recommend conducting more in-depth investigations.
Pentraxin-3 modulates hepatocyte ferroptosis and the innate immune response in LPS-induced liver injury
Authors: Wang Huitong , Su Zhaojie , Qian Yunyun , Shi Baojie , Li Hao , An Wenbin , Xiao Yi , Qiu Cheng , Guo Zhixiang , Zhong Jianfa , Wu Xia , Chen Jiajia , Wang Ying , Zeng Wei , Zhan Linghui , Wang Jie 
Published: December 2024

AbstractThe liver plays a crucial role in the immune response during endotoxemia and is one of the critical targets for sepsis-related injuries. As a secretory factor involved in inflammation, pentraxin-3 (PTX3) has been demonstrated to regulate hepatic homeostasis; however, the relationship between PTX3 and cell crosstalk between immune cells and hepatocytes in the liver remains incompletely understood. In this study, we revealed that, compared with WT mice, Ptx3−/− mice with lipopolysaccharide (LPS)-induced endotoxemia exhibited alleviated liver damage, with reduced serum alanine transaminase and aspartate transaminase levels and an improved survival rate. Mechanistically, RNA-Seq and western blot results revealed that Ptx3 knockdown in hepatocytes increased the expression of Tfrc and Ccl20; consequently, Ptx3 deficiency regulated LPS-induced hepatocyte ferroptosis via increased mitochondrial reactive oxygen species and Fe2+ and recruited more macrophages by CCL20/CCR6 axis to be involved in inflammation and the clearance of harmful substances. Moreover, western blot and immunofluorescence staining confirmed that the NF-κB signaling pathway was upregulated upon LPS treatment in Ptx3-knockdown macrophages, promoting phagocytosis and polarization toward M1 macrophages. Collectively, our findings show that the absence of Ptx3 can ameliorate sepsis-induced liver injury by regulating hepatocyte ferroptosis and promote the recruitment and polarization of M1 macrophages. These findings offer a key basis for the development of effective treatments for acute infections.
A Unique Phenotype of Maturity-Onset Diabetes of the Young With a Novel Disease-Causing Insulin Gene Variant
Authors: Chua Cherie , Tan Clara Si Hua , Lim Su Chi , Vasanwala Rashida Farhad 
Published: December 2024

Abstract
Maturity-onset diabetes of the young (MODY) represents 1% to 5% of patients with diabetes mellitus (DM), and numerous genes associated with MODY have been identified. While mutations of the insulin gene (INS) are known to cause permanent neonatal DM, rare disease-causing variants have also been found in MODY. These patients demonstrate variable clinical phenotypes—from milder forms requiring lifestyle or oral agent interventions to severe forms requiring lifelong insulin. We present a case of MODY arising from a novel disease-causing INS variant, in an adolescent with atypical features. He was obese with clinical evidence of insulin resistance, diagnosed with DM through opportunistic oral glucose tolerance testing. He developed symptomatic hyperglycemia with worsening glycemic trend, requiring treatment with high-dose insulin and metformin. After 2.5 years, his glycemic profile normalized following weight loss, and pharmacotherapy was discontinued. Targeted gene testing revealed a de novo novel missense variant in exon 2 of the INS gene (p.His29Tyr), confirmed using bidirectional Sanger sequencing. Insulin resistance in patients with MODY can worsen their clinical course and increase risks of long-term complications. Management of these patients should be individualized. This case highlights the utility of genetic testing in diagnosing uncommon and variable forms of MODY, particularly those with atypical features.
Role of Thyrotropin-Releasing Hormone Stimulation Test and Autoantibody in 952 Subjects with Subclinical Hypothyroidism
Authors: Yoo Myung Hi , Kim Hye Jeong , Park Suyeon , Park Sang Joon , Park Hyeong Kyu , Byun Dong Won , Suh Kyoil 
Published: December 2024

Abstract

Context
Subclinical hypothyroidism (SCH) is characterized by elevated thyroid-stimulating hormone (TSH) levels and normal free thyroxine (fT4) levels. In upper normal TSH levels, thyrotropin-releasing hormone (TRH) stimulation test proved to be useful in identifying an exaggerated TSH response.

Objective
We aimed to evaluate the incidence and predictive ability of basal TSH, anti-thyroid peroxidase antibodies (TPOAb), and anti-thyroglobulin antibodies (TgAb) for exaggerated TRH stimulation test in SCH.

Methods
A total of 952 subjects with SCH (TSH 4.01-10.00 mIU/L) found during health checkups were evaluated for TSH response to TRH stimulation testing and autoantibodies. Exaggerated TSH response was defined as ΔTSH (peak serum TSH level after TRH injection minus basal TSH level) of &gt; 25.00 mIU/L.

Results
The prevalence of exaggerated TSH responses in SCH was 66% (n = 633). The proportion of exaggerated TSH response tended to increase as basal TSH levels increased (P for trend &lt;.001). Also, the proportion of positive TPOAb or TgAb tended to increase as basal TSH levels increased (P for trend &lt;.05). Analysis of predictive ability of basal TSH, positive TPOAb, or TgAb for exaggerated TRH stimulation test revealed that positive TPOAb or TgAb showed high specificity (&gt; 90%) for positive TRH stimulation test but low sensitivity. Basal TSH showed low sensitivity and specificity.

Conclusion
Two-thirds of SCH showed exaggerated TRH stimulation test. Positive TPOAb or TgAb showed high specificity (&gt; 90%) for positive TRH stimulation test but basal serum TSH levels showed low predictability. The TRH stimulation test may be a valuable guide to identify SCH patients with hypothyroid state.
The Ethics and Pragmatics of Ethnographic Refusal/Acceptance
Authors: Fadil Nadia 
Published: December 2024

Abstract
Ethnographic refusal has been thematized as a challenge by many anthropologists. However, instead of approaching it simply as a problem, this article seeks to understand how both refusal and acceptance are socially related, appear on a continuum, and many times co-constitute and inform each other. Attending carefully to the various iterations of refusal/acceptance can serve as an entry point to study the effects of power and, just as importantly, consider the distinct methodological and ethical considerations that are at stake. In so doing, the article examines and shows how refusal/acceptance works, following Isabelle Stenger, in “making sense in common,” which figures here as a prerequisite for the ethnographic encounter. It presents two ethnographic vignettes, drawing on work with Muslims in Belgium, that reflect two moments of refusal/acceptance: one wherein refusal/acceptance operates as a technology for one's political agency and a second one in which refusal/acceptance partakes in the construction of an intimate sociality.
Decolonizing the Race Debate about North Africa
Authors: Salime Zakia 
Published: December 2024

Abstract
This essay discusses the discourse of race and racism as a “new zone” of theory grounded in orientalist claims about discovery and saving. It shows how this discourse centers slavery as an ultimate lens through which to understand the race question in the North Africa. The essay asks these questions: why have race and migration in North Africa and the Middle East become such an active zone of theory? Which concepts and frameworks dominate the scholarly debates, and with what political effects? These are consequential questions that the Moroccan case can help answer. A decolonial ethics should begin with the vibrant debates already taking place in Morocco. Moroccans’ engagement with the question of race preceded its discovery as a new field for generating expertise by Western-based scholars and journalists.
To determine the effects of burnout and compassion fatigue on registered nurses' ability to deliver patient care
Authors: Girleanu Isabela 
Published: December 2024

Background This review aimed to determine the effects of burnout and compassion fatigue on nurses' ability to deliver patient care and to aid in highlighting the steps required to overcome this and obtain a healthier nursing workforce. Methods A narrative review methodology was used. A systematic search of Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline and Excerpta Medica Database (EMBASE) sourced 12,212 acticles. Findings A total of 20 articles met the inclusion criteria. Two recurrent themes emerged from the literature. These were factors delivery of patient care and quality and safety of patient care. Conclusion Burnout and compassion fatigue negatively impacts the delivery, quality and safety of patient care. There is a gap in the literature examining the effect long-term burnout and compassion fatigue has on the delivery of patient care which needs to be addressed.
Colon capsule endoscopy polyp detection rate vs colonoscopy polyp detection rate: Systematic review and meta-analysis
Authors: Woods Marc , Soldera Jonathan 
Published: December 2024

BACKGROUND
Colon capsule endoscopy (CCE) is a modern, non-invasive method for large bowel visualization, offering a less invasive alternative to traditional colonoscopy (TC). While TC remains the gold standard for comprehensive large bowel assessment, including the detection and treatment of various conditions, the effectiveness of CCE in detecting polyps is less established.
AIM
To systematically review and compare the polyp detection rates (PDR) of CCE and TC.
METHODS
A systematic literature search was conducted using four scientific databases: CINAHL, MEDLINE via EBSCO, Cochrane Library, and MEDLINE/PubMed. A standardized search command was utilized to ensure consistency. Full papers were retrieved if they compared PDR between CCE and TC and involved patients over 18 years old. A meta-analysis was then conducted using the meta package in R software.
RESULTS
Initially, 339 articles were identified, with 128 duplicates and 15 non-English articles excluded, leaving 196 for screening. After further exclusions, 9 articles were included in the review. The meta-analysis revealed minimal differences in PDR between CCE and TC. The pooled PDR for TC was 0.61 (95%CI: 0.48–0.72), and for CCE, it was 0.61 (95%CI: 0.48–0.73). The overall comparison of the pooled PDR of both methods was 0.96 (95%CI: 0.90–1.02), indicating that CCE is non-inferior to TC.
CONCLUSION
CCE has emerged as a modern and safe diagnostic alternative to TC for polyp detection, demonstrating non-inferiority when compared to the conventional method.
Aerosol Typing from Linear estimations for the Analytical Separation (ATLAS) of complex aerosol mixtures and improved identification of microphysical parameters from multiwavelength lidar data, part 1: theory and numerical simulations
Authors: Kolgotin Alexei , Müller Detlef 
Published: December 2024

We developed a mathematical model that is used for describing the relationships between the intensive parameters (IPs) of arbitrary external aerosol mixtures (AMs) and the intensive parameters of the aerosol components in these AMs. We denote this procedure as aerosol typing and aerosol characterization, respectively. The IPs of AMs can be found from multiwavelength lidar measurements of backscatter coefficients (β) at 355, 532, and 1064 nm; extinction coefficients (α) at 355 and 532 nm; particle linear depolarization ratios (δ) at 355, 532, and 1064 nm; and fluorescence backscattering coefficients (β
F
). The IPs of the AM components are known a priori. The mathematical model allows us to obtain by analytical linear estimations the fractions of all components that are contained in complex AMs in terms of extinction and backscatter coefficients at the available lidar-measurement wavelengths. We carry out numerical simulations to test the correctness of this approach of Aerosol Typing from Linear estimations for the Analytical Separation (ATLAS) of aerosol mixtures. We test the sensitivity of ATLAS to measurement errors and incorrectly given IPs of AM components. Our numerical simulations show that the uncertainty of ATLAS is proportional to measurement errors and the uncertainty of the given IPs.
Resource intensity of the digital transformation in Germany
Authors: Milde Katharina , Meyer Mark , Kirchdorfer Roman , Haack Daniel 
Published: December 2024

The project “Digitalisation and natural resources” (DigitalRessourcen) analyzed the resource intensity of digitalization in Germany. Various micro- and macro-level analyses were conducted and areas for shaping sustainable digitalization were identified. At the micro-level, the resource requirements and environmental impacts of digital products and services were calculated on the basis of case studies using life cycle assessment principles. At the macro-level, input-output models were applied to determine the need for raw materials and the CO2 emissions of the digitalization in Germany for the national economy. The micro-level analyses confirmed the expected correlation between raw material use, energy use, and global warming potential. The main causes here were identified in the manufacturing and use phases. Macro-level analyses revealed that, besides domestic demand dependencies, the close links between the German economy and international trade could be an obstacle to reducing the raw material and CO2 intensity of digitalization.
Implementing Biodrying Method for Waste Processing in Salatiga City
Authors: Hardyanti Nurandani , Zaman Badrus , Bagaskhara Rezza Anferditya , Hasfiawan Harsya Giras 
Published: December 2024

Waste processing in Salatiga City could have been more optimal. It can be seen from the data from the Salatiga City Environment Service that the waste processing facility in the form of an active waste processing site with reduce-reuse-recycle is only one out of seven registered units. This has the potential to cause accumulation at the final processing site. Therefore, it is necessary to develop an effective waste processing facility. Planning for waste processing using the biodrying method can effectively process waste that produces products in the form of Refuse Derived Fuel (RDF)[1] [Ma2] . Planning for waste processing is carried out until 2032 in two service areas: Service area 1 (Argomulyo District and Tingkir District) and service area 2 (Sidorejo District and Sidomukti District). The amount of waste generated by service area 1 reaches 49.33 tons/day and 522.67 m3/day, while service area 2 reaches 49.62 tons/day and 414.01 m3/day. Planning for waste processing using the drying method includes picking bay units, shredding, drying, screening, and loading RDF.[3] [Ma4] RDFs potential in 2032 as a result of waste processing in service area 1 is 11159.03 tons/year with sales of Rp. 7,270,755,009 / year and in service area 2 it is 10,471.09 tons / year with sales of Rp. 6,822,524,206 / year
Utilization of Black Soldier Fly Larvae in Processing Expired Food Waste with Various Composition
Authors: Yunita Silma Maya , Siwiendrayanti Arum , Nurjanah Nurjanah 
Published: December 2024

The study aimed to evaluate the effectiveness of Black Soldier Fly (BSF) larvae in processing expired food waste with different compositions, including expired instant noodles, bread, and milk, compared to a cassava pulp control. A true experimental design using a Posttest Only Control Group and Complete Random Design was employed. Over 15 days, temperature, pH, moisture, and waste reduction were measured. The results indicated that BSF larvae were most effective in reducing waste when fed expired instant noodles, with a Waste Reduction Index (WRI) of 5.68%, followed by bread (5.61%) and milk (5.47%). The lowest WRI was observed in the cassava pulp control group (5.28%). Statistical analysis using One Way ANOVA showed significant differences in WRI values among the waste compositions, confirming that BSF larvae efficiently reduce organic waste, particularly expired food, offering a sustainable solution for waste management.