bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of domain-specific epistemological beliefs of physiotherapists: A longitudinal study
Authors: Bientzle Martina , Cress Ulrike , Kimmerle Joachim 
Published: October 2019

Abstract
Background
Epistemological beliefs (EBs) and therapeutic health concepts are two important factors of influence that affect how healthcare professionals process treatment-relevant information. A previous investigation compared physiotherapy students’ EBs and therapeutic health concepts with those of professionals in a cross-sectional study. That study design, however, did not allow for any conclusions about the temporal development of these concepts. This shortcoming has been addressed in the study presented here, which aimed to assess that temporal development.
Methods
In a longitudinal study, physiotherapists filled in a questionnaire that measured their personal EBs about physiotherapy and about medicine, as well as their biomedical and biopsychosocial therapeutic health concepts. The participants were first examined during their medical training (December 2011). The follow-up measure was about three years later when the participants had become professional physiotherapists (January 2015). The development of their EBs was examined using paired sample t-tests and Wilcoxon signed-rank test.
Results
The analysis was based on 41 participants who filled in the questionnaire at both time points and were working as physiotherapists at the time of the second measurement. There was a development of physiotherapy-related and a development of medicine-related EBs: Physiotherapy-related as well as medicine-related EBs were more sophisticated when physiotherapists had already entered the working world than during their physiotherapy training. Due to psychometric problems of the scales, the development of their therapeutic health concepts could not be analyzed.
Conclusions
EBs are an important factor for (lifelong)learning. Physiotherapy-related and medicine-related EBs developed similarly in both domains. This is an indication that the temporal development of EBs is an expression of professionalization of healthcare personnel in their occupational field. The findings demonstrate that the development of EBs is not completed at the end of vocational training; it appears to be a development that continues even after the transition to professional life.
Epstein-Barr Encephalitis in a Child with Congenital Human Immunodeficiency Virus Infection: A Case Report Calling for No Forgetfulness
Authors: Tsiatsiou Olga , Papachristou Savvas , Papadimitriou Eleni , Michailidou Elisavet , Chatzidimitriou Dimitrios , Papa Anna , Doulioglou Vai , Karyda Stavroula , Antachopoulos Charalampos , Roilides Emmanuel 
Published: October 2019

Background:
In resource-rich settings, the rate of mother-to-child transmission of human
immunodeficiency virus (HIV) has dramatically decreased by virtue of a combination of preventive
strategies during the last two decades.

Case Presentation:
We present a case of progressive developmental milestone loss in a toddler with
previously unknown congenitally acquired human immunodeficiency virus (HIV) infection, complicated
by an Epstein-Barr virus (EBV) coinfection.

Conclusion:
Our report underscores the differential diagnosis between HIV encephalopathy and
EBV encephalitis and the vertical transmission of the HIV infection, which constitutes an alarming
issue in terms of public health.
A Neuroinflammation Inhibitor, Hypoxylon xanthone A, from Soil Fungus Hypoxylon sp.
Authors: Xiao Ying , Xu Bing , Kang You , Li Yuedi , Cui Yong , Liu Wei , Xiang Zheng 
Published: October 2019

:
Hypoxylon sp. was used to ferment at 25°C for 45 days. The solid culture of Hypoxylon sp.
was extracted with 75% EtOH under ultrasonic for twice. And the dried combined extracts were then
suspended in H2O and partitioned with ethyl acetate. EtOAc extracts were subjected to a silica gel column
and eluted with petroleum ether - acetone to a.ord seven fractions. Sephadex LH-20 and RPHPLC
were used subsequently to yield a novel xanthone metabolite (Hypoxylon xanthone A). Its structure
was elucidated based on HR-ESI-MS, 1D-, 2D-NMR spectra, and the comparison of the experimental
and calculated ECD spectra. The anti-neuroinflammatory assay of Hypoxylon xanthone A, as
manifested by the inhibitory effect on LPS-induced NO production in BV-2 microglial cells, indicated
almost the same inhibitory effect as minocycline in a dose-dependent manner within the concentration
of 1-50 μM, suggesting that Hypoxylon xanthone A could be a new potential neuroinflammation inhibitor.
Synthesis and Evaluation of Aryl Substituted Propyl Piperazines for Potential Atypical Antipsychotic Activity
Authors: Singh Shalu , Bali Alka , Peshin Tania 
Published: October 2019

Background:
Schizophrenia is a disorder with complex etiology with hyperdopaminergia
as the leading underlying cause. Atypical antipsychotics are the agents which do not give rise
to significant extrapyramidal side effects and are more effective against negative symptoms of
schizophrenia.

Introduction:
A new series of chloro-substituted substituted aryloxypiperazine derivatives and their indole based derivatives was designed and evaluated for atypical antipsychotic activity based on established models for combined dopaminergic and serotonergic antagonism.

Methods:
The present series of compounds were designed based on 3D similarity studies, synthesized
and evaluated for atypical antipsychotic activity in animal models for combined dopaminergic
and serotonergic antagonism. The blood-brain barrier penetration potential was assessed from
theoretical log BB values computed through an online software program.

Results:
Theoretical ADME profiling of the designed compounds based on selected physicochemical
parameters suggested excellent compliance with Lipinski’s rules. The log BB values obtained
for the compounds suggested a good potential for brain permeation. Indole substitution contributed
towards an improved efficacy over aryloxy analogs. Lead compounds showed a potential for combined
dopaminergic and serotonergic antagonism.

Conclusion:
The 5-methoxy indole based compounds 16 and 17 were identified as the lead compounds
displaying a potential atypical antipsychotic profile.
Chimeric Antigen Receptor-Engineered T-Cells - A New Way and Era for Lymphoma Treatment
Authors: Mihăilă Romeo G. 
Published: October 2019

Background:
Patients with refractory or relapsed diffuse large B-cell lymphoma have a poor
prognosis with the current standard of care.

Objective:
Chimeric Antigen Receptor T-cells (CAR T-cells) are functionally reprogrammed lymphocytes,
which are able to recognize and kill tumor cells. The aim of this study is to make progress in this
area.

Method:
A mini-review was achieved using the articles published in Web of Science and PubMed in
the last year and the new patents were made in this field.

Results:
The responses to CAR T-cell products axicabtagene ciloleucel and tisagenlecleucel are promising;
the objective response rate can reach up to 83%, and the complete response rate ranges between
40 and 58%. About half of the patients may have serious side effects, such as cytokine release syndrome
and neurotoxicity. Current and future developments include the improvement of CAR T-cell
expansion and polyfunctionality, the combined use of CAR T-cells with a fusion protein between interferon
and an anti-CD20 monoclonal antibody, with checkpoint inhibitors or small molecule sensitizers
that have apoptotic-regulatory effects. Furthermore, the use of IL-12-expressing CAR T-cells, an improved
technology for the production of CAR T-cells based on targeted nucleases, the widespread use
of allogeneic CAR T-cells or universal CAR T-cells obtained from genetically engineered healthy donor
T-cells are future developments actively considered.

Conclusion:
CAR T-cell therapy significantly improved the outcome of patients with relapsed or refractory
diffuse large B-cell lymphoma. The advances in CAR T-cells production technology will improve
the results and enable the expansion of this new immunotherapy.
Medical Conditions Predictive of Self-Reported Poor Health: Retrospective Cohort Study
Authors: Cepeda M Soledad , Reps Jenna , Kern David M , Stang Paul 
Published: October 2019

Background
Identifying the medical conditions that are associated with poor health is crucial to prioritize decisions for future research and organizing care. However, assessing the burden of disease in the general population is complex, lengthy, and expensive. Claims databases that include self-reported health status can be used to assess the impact of medical conditions on the health in a population.

Objective
This study aimed to identify medical conditions that are highly predictive of poor health status using claims databases.

Methods
To determine the medical conditions most highly predictive of poor health status, we used a retrospective cohort study using 2 US claims databases. Subjects were commercially insured patients. Health status was measured using a self-report health status response. All medical conditions were included in a least absolute shrinkage and selection operator regression model to assess which conditions were associated with poor versus excellent health.

Results
A total of 1,186,871 subjects were included; 61.64% (731,587/1,186,871) reported having excellent or very good health. The leading medical conditions associated with poor health were cancer-related conditions, demyelinating disorders, diabetes, diabetic complications, psychiatric illnesses (mood disorders and schizophrenia), sleep disorders, seizures, male reproductive tract infections, chronic obstructive pulmonary disease, cardiomyopathy, dementia, and headaches.

Conclusions
Understanding the impact of disease in a commercially insured population is critical to identify subjects who may be at risk for reduced productivity and job loss. Claims database studies can measure the impact of medical conditions on the health status in a population and to assess changes overtime and could limit the need to collect prospective collection of information, which is slow and expensive, to assess disease burden. Leading medical conditions associated with poor health in a commercially insured population were the ones associated with high burden of disease such as cancer-related conditions, demyelinating disorders, diabetes, diabetic complications, psychiatric illnesses (mood disorders and schizophrenia), infections, chronic obstructive pulmonary disease, cardiomyopathy, and dementia. However, sleep disorders, seizures, male reproductive tract infections, and headaches were also part of the leading medical conditions associated with poor health that had not been identified before as being associated with poor health and deserve more attention.
A Mobile App for Longterm Monitoring of Narcolepsy Symptoms: Design, Development, and Evaluation
Authors: Quaedackers Laury , De Wit Jan , Pillen Sigrid , Van Gilst Merel , Batalas Nikolaos , Lammers Gert Jan , Markopoulos Panos , Overeem Sebastiaan 
Published: October 2019

BackgroundNarcolepsy is a chronic sleep disorder with a broad variety of symptoms. Although narcolepsy is primarily characterized by excessive daytime sleepiness and cataplexy (loss of muscle control triggered by emotions), patients may suffer from hypnagogic hallucinations, sleep paralysis, and fragmented night sleep. However, the spectrum of narcolepsy also includes symptoms not related to sleep, such as cognitive or psychiatric problems. Symptoms vary greatly among patients and day-to-day variance can be considerable. Available narcolepsy questionnaires do not cover the whole symptom spectrum and may not capture symptom variability. Therefore, there is a clinical need for tools to monitor narcolepsy symptoms over time to evaluate their burden and the effect of treatment.ObjectiveThis study aimed to describe the design, development, implementation, and evaluation of the Narcolepsy Monitor, a companion app for long-term symptom monitoring in narcolepsy patients.MethodsAfter several iterations during which content, interaction design, data management, and security were critically evaluated, a complete version of the app was built. The Narcolepsy Monitor allows patients to report a broad spectrum of experienced symptoms and rate their severity based on the level of burden that each symptom imposes. The app emphasizes the reporting of changes in relative severity of the symptoms. A total of 7 patients with narcolepsy were recruited and asked to use the app for 30 days. Evaluation was done by using in-depth interviews and user experience questionnaire.ResultsWe designed and developed a final version of the Narcolepsy Monitor after which user evaluation took place. Patients used the app on an average of 45.3 (SD 19.2) days. The app was opened on 35% of those days. Daytime sleepiness was the most dynamic symptom, with a mean number of changes of 5.5 (SD 3.7) per month, in contrast to feelings of anxiety or panic, which was only moved 0.3 (SD 0.7) times per month. Mean symptom scores were highest for daytime sleepiness (1.8 [SD 1.0]), followed by lack of energy (1.6 [SD 1.4]) and often awake at night (1.5 [SD 1.0]). The personal in-depth interviews revealed 3 major themes: (1) reasons to use, (2) usability, and (3) features. Overall, patients appreciated the concept of ranking symptoms on subjective burden and found the app easy to use.ConclusionsThe Narcolepsy Monitor appears to be a helpful tool to gain more insight into the individual burden of narcolepsy symptoms over time and may serve as a patient-reported outcome measure for this debilitating disorder.
An Online Pain Education Program for Working Adults: Pilot Randomized Controlled Trial
Authors: Li Yajie , Tse Mun Yee Mimi 
Published: October 2019

Background
Pain is a common public health concern, and the pain situation among the general population is serious in mainland China. Working adults commonly experience pain because of long sitting times, a lack of free time, and exercise. A lack of pain-related knowledge is also a significant factor. Educational and therapeutic programs delivered online were used more often in Western countries, and accessible programs in China are limited, especially for pain management. Therefore, we carried out an online pain education program for working adults to self-manage pain. The program was delivered through WeChat, a popular and secure social media with a large population base in China.

Objective
This study aimed to (1) provide pain-related knowledge and self-relief strategies, (2) help participants reduce pain and improve pain-related emotional well-being, and (3) explore participants’ learning performance and the acceptability of the online pain education program.

Methods
This was a randomized controlled trial. Chinese adults aged between 16 and 60 years with full-time employment, with pain in the past 6 months, and without any mental illness were recruited using snowball sampling through the internet and were randomly allocated to an experimental group and a control group in 1:1 ratio after the baseline assessment. The 4-week educational program that included basic knowledge of pain, pharmacological and nonpharmacological treatments, and related resources was provided only to the experimental group. Outcomes of pain, depression, anxiety, stress, and pain self-efficacy were measured at baseline (T0), posttreatment (T1), and 1-month follow-up (T2). Participants’ acceptability and satisfaction were explored after completing the educational program.

Results
In total, 95 eligible participants joined in the program: 47 in the experimental group and 48 in the control group. Neck and shoulder, head, and back were most commonly reported pain sites with high pain scores. Pain intensity and interference of the experimental group were significantly reduced after the educational program. Depression, anxiety, and stress clinically improved and pain self-efficacy improved after the educational program. The difference in depression, anxiety, stress, and pain self-efficacy within a group or between groups was not statistically significant; however, clinical improvements were demonstrated. A significant correlation between dosage of the intervention and pain intensity and depression was demonstrated. After completing the educational program, more than half of the participants showed acceptance of and satisfaction with the program, and they were willing to recommend the program to others.

Conclusions
Our findings highlight the significant potential of this online education program in the treatment of pain.

Trial Registration
ClinicalTrials.gov NCT03952910; https://clinicaltrials.gov/ct2/show/NCT03952910
Hipoterapia: alternativa para el abordaje terapéutico de las discapacidades neuromotoras
Authors: Sarmiento Vega Salvador Ernesto , Barradas Alarcón María Esther , León Noris Martha Lilia , López González Javier , Posadas Tello Mayra Helen 
Published: October 2019

El objetivo de este estudio fue analizar la interrelación entre los elementos participantes en la tríada terapéutica (cliente o paciente, equino y facilitador) durante el proceso terapéutico de un paciente masculino de 27 años con diagnóstico de lesión medular C6-7. Para ello, se empleó la hipoterapia como una propuesta alternativa y complementaria para el tratamiento de personas con o sin discapacidad; esta es una actividad que promueve el potencial humano de desarrollo utilizando al caballo y a su entorno como la base de la terapia. La investigación fue planteada desde la perspectiva de la investigación cualitativa. Por sus características se considera como un trabajo de carácter exploratorio. El método empleado se ajusta a los postulados del modelo de la teoría fundamentada. El tipo de estudio fue el análisis de caso clínico. Para la recolección de datos se empleó la técnica documental biográfica. La información fue procesada mediante la técnica de análisis de contenido, con apoyo en las perspectivas teóricas de la neurofisiología aplicada al campo de la hipoterapia, la comunicación interespecies (humano-equino) y el enfoque centrado en la persona. Las observaciones obtenidas del análisis del discurso muestran claramente el cumplimiento de los principios señalados para cada uno de los modelos teóricos empleados. De hecho, los resultados obtenidos son similares a los reportados por otros autores en cuanto a la utilidad del caballo como coterapeuta en virtud de sus características y reacciones, las cuales poseen una importante similitud con las condiciones terapéuticas descritas en el modelo centrado en la persona para facilitar el proceso de cambio, es decir, la aceptación incondicional, la congruencia y la empatía.
Tuntevasti Suomessa puhutuista kielistä ja kielitietoisuudesta
Authors: Karttunen Miia 
Published: October 2019

Arvioitu teos
Mari Honko & Sanna Mustonen (toim.): Tunne kieli. Matka maailman kieliin ja kielitietoisuuteen. Helsinki: Finn Lectura 2018. 474 s. isbn 978-951-792-923-3.
Vuorovaikutuslingvistiikan jättiläinen
Authors: Suomalainen Karita 
Published: October 2019

Arvioitu teos
Elizabeth Couper-Kuhlen & Margret Selting: Interactional linguistics. Studying language in social interaction. Cambridge University Press 2018. 617 + 291 s. isbn 978-1-107-61603-5.
Pohjoisgermaanin ja itämerensuomen äännehistoriallisten ilmiöiden selityksiä täydentävä väitöstutkimus
Authors: Heikkilä Mikko 
Published: October 2019

Arvio teoksesta
Johan Schalin: Preliterary Scandinavian sound change viewed from the east. Umlaut remodelled and language contact revisited. Nordica Helsingiensia 54. Helsinki: Helsingin yliopisto 2018. 411 s. isbn 978-951-51-4387-7.
Suomen <i>no</i>-partikkeli ja kysymyksiin vastaaminen keskustelussa (tulossa)
Authors: Vepsäläinen Heidi 
Published: October 2019

Heidi Vepsäläisen suomen kielen alaan kuuluva väitöskirja tarkastettiin Helsingin yliopistossa maanantaina 20. toukokuuta 2019. Vastaväittäjänä toimi FT, maître de conférences Outi Duvallon INALCOsta ja kustoksena professori Marja-Leena Sorjonen.
Heidi Vepsäläinen: Suomen "no"-partikkeli ja kysymyksiin vastaaminen keskustelussa. Helsinki: Helsingin yliopisto 2019. Kirja on luettavissa osoitteessa http://urn.fi/URN:ISBN:978-951-51-5189-6.
Suunvuoro
Authors: Lappalainen Hanna 
Published: October 2019

Suunvuoro
Virittäjä valmistautuu juhlimaan: lehti täyttää vuonna 2022 peräti 125 vuotta, ja edellisvuonna eli 2021 ilmestyy sen 125. vuosikerta. Kutsumme jo tässä vaiheessa alan tutkijat ja opiskelijat sekä muut lehden lukijat ja ystävät mukaan juhliin. Lähtö­laukauksena toimikoon kirjoituskutsu, jolla haastamme fennistiikasta ja sen historias­ta kiinnostuneet tarkastelemaan Virittäjää eri näkökulmista. Etsimme kirjoituksia eri osastoihin: artikkelien lisäksi esimerkiksi lyhyemmät havaintokirjoitukset ovat terve­tulleita. Kirjoitukset käyvät läpi normaalin arviointimenettelyn, joten odotamme vertais­arvioitavia kirjoituksia elokuun 2020 loppuun mennessä, muita tekstejä viimeistään ensi vuoden loppuun mennessä. Tarkempi kirjoituskutsu julkaistaan Virittäjän verkko­sivuilla lokakuun aikana.
Juhlanumeroa ei ole tarpeen kehitellä siksi, että Virittäjässä olisi pulaa kirjoituksista. Tarjonta on edelleen runsasta, mikä ei ole itsestäänselvää tilanteessa, jossa paine julkaista englannin kielellä on kasvanut myös kansallisten tieteiden parissa. Juhla­numerolla haluamme varmistaa, että merkkivuodesta jää myös konkreettisia jälkiä, joihin seuraavat sukupolvet voivat palata.
Tämän numeron artikkelit ja muut kirjoitukset kuvastavat jälleen kielen­tutkimuksen kirjoa. Mukana on sekä perus- että soveltavaa tutkimusta, puhutun ja kirjoitetun kielen tarkastelua, kvantitatiivista ja kvalitatiivista, diakronista ja synkronista. Inkeri Lehti­maja ja Lari Kotilainen osoittavat kakkoskielisen puhujan eri­linjaisia vastaus­vuoroja ja niiden vastaanottoa analysoimalla, miten moninaisin tavoin ymmärrys­ongelmat voivat näkyä vuorovaikutuksessa. Lukiolaisten esseetekstejä tutkiva Hilkka Paldanius puolestaan näyttää, kuinka tavat, joilla kirjoittajat esittelevät ­tehtävän aineistoksi annettuja teksti- ja kuvadokumentteja, kertovat heidän historian osaamisestaan. Saara Huhmarniemen tutkimuskohteena on tunne­kausatiivien argumentti­rakenne. Tässä numerossa julkaistavassa artikkelissa tarkastellaan tapauk­sia, joissa aiheuttajana on NP. Myöhemmin on luvassa jatko-osa, jossa poraudutaan lausemaiseen aiheuttajaan. Lähisukukieli karjala on tarkasteltavana sekä Susanna Tavin ja Lauri Tavin artikkelissa että Denis Kuzminin havaintokirjoituksessa. Tavin ja Tavin huomion kohteena ovat raja­karjalan kontaktit niin venäjän kuin suomen kanssa, Kuzmin tarkastelee karjalan esikristillistä naistennimistöä etsimällä sen jälkiä esi­merkiksi lehmän­nimistä. Kiinnostavaa kokonaisuutta täydentävät verkko­liitteen lektiot, Marja Leinosen elämäntyötä esittelevä muistokirjoitus, Jaakko Anhavan keskustelu­puheenvuoro sekä eri kielitieteen suuntauk­sia esittelevät kirja-arviot.
Hanna Lappalainen
PEMODELAN PREFERENSI PENGAJUAN KREDIT USAHA MIKRO (KUM) DI BANK X OLEH PEMILIK USAHA MIKRO DI SURABAYA DENGAN METODE CHAID
Authors: Ariestanti Niken , Prilianti Kestrilia Rega 
Published: October 2019

In the aim of developing and strengthening the micro, small and medium enterprises (MSMEs), the government of Indonesia provide financial support for MSMEs enterpreneur through commercial loans which is held by several national bank. In order to assure that the loan goes to the right enterpreneur, those banks need some information about the MSMEs entepreneur’s preference in applying the MSMEs loan. These preference could be predicted by exploring the enterpreneur’s characteristics. One of the quantitative method called CHAID (Chi-Squared Automatic Interaction Detection Analysis) has been used in this research to provide that prediction. With this method, the MSMEs enterpreneur’s preferences on loan application and loan products were modeled by two classification tree.