bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of flow cytometric immuno-phenotyping of acute myeloid leukemia with minimal differentiation and acute T-cell lymphoblastic leukemia: A retrospective cross-sectional study
Authors: Al-Saadi Enass Abdul Kareem Dagher , Abdulnabi Marwa Ali , Jaafar Faris Hanoon 
Published: September 2020

Background: Acute leukemias (ALs) are a heterogeneous group of malignancies with various clinical, morphological, immunophenotypic, and molecular characteristics. Distinguishing between lymphoid and myeloid leukemia is often performed by flow cytometry. This study aimed to evaluate the immunophenotypic characterization and expression of immuno-markers in both acute myeloid leukemia (AML-M0) and acute T-cell lymphoblastic leukemia (T-ALL). Methods: A retrospective cross-sectional study was conducted in the Pathology Department/Teaching Laboratories/Medical City/Iraq and included all patients newly diagnosed with AL from 5 January to 10 December 2018. Immunophenotypic analysis was performed on bone marrow samples, freshly collected in EDTA tubes. Flow cytometry (Canto-2 BD) was used, with laser excitation of blue and red wavelengths. A panel of monoclonal antibodies (MoAbs) was used for diagnosis, using a SSC/CD45 gating strategy. Results: The study showed 41.6% of AML-M0 patients had no aberrant antigen expression, while 33.3%, 16.6%, 8.3%, and 8.3% had aberrant CD7, CD56, CD2, and CD19, respectively. In 16.6% of AML-M0 cases more than one aberrant antigen was expressed. With regard to T-ALL, 7.0% were pro-T type, 58.0% were pre-T, 13.0% were cortical, and 22.0% were mature-T type. In 55.5% of patients with T-ALL there was no aberrant antigen expression. Conclusion: We concluded that most patients with AML-M0 have no aberrant antigen expression. In patients with T-ALL, the pre-T type is most common, according to the European Group for the Immunological Classification of Leukemias (EGIL) classification. Patients with T-ALL also generally lack aberrant antigen expression.
Threshold conditions of electric field enhancement and energy confinement in the low-index core of nanoscale waveguides
Authors: Wang Suoming , Zhu Yanying , Ma Wanli , Luo Sijie , Zhu Erkuang , Chen Shuqing 
Published: September 2020

Threshold conditions to realize electric field enhancement and energy confinement in the low-refractive-index core of nanoscale waveguides are studied by solving the field function. When the incident lightwave meets the relation of special thresholds, we observe the enhanced electric field and a concentrated light energy in the core. The electric field enhancement and the confined light power are highly dependent on the light wavelength. When the core width is 30 nm, for a wavelength of 1.55 µm, we achieve a power confinement factor above 40%. As the basis for a growing number of potential applications, the threshold conditions discovered in this work will find significant applications in many fields, such as optical sensors and optical communication components.
Regulatory Arbitrage and Non-Judicial Debt Collection in Central and Eastern Europe
Authors: Stănescu Cătălin-Gabriel , Bogdan Camelia 
Published: September 2020

Abstract
Non-judicial recovery of debts is now rampant in Central and Eastern Europe (CEE). The reason is two-fold. On the one hand, the significant number of defaults in the poorer areas of Europe makes the CEE region a very attractive market for debt-collection. On the other hand, the activity is almost entirely unregulated, especially regarding abusive debt collection practices. The CEE region still lacks mature, strong, and experienced supervisory agencies that could tackle borderline activities. This enables companies involved in debt collection to comply easily with the minimal legal provisions and to circumvent the actual purpose of the law, including through tax sheltering and money laundering. The main argument developed in the paper is that the debt collection system it is designed to maximize profits, minimize tax base and, potentially, can serve as money laundering mechanism. The system functions in a triadic relationship: the debt-seller (a credit institution), the debt-buyer (usually an investment company), and the debt-administrator (a debt-collection agency, either fully owned by, or under the control of the debt-buyer), where debt portfolios are purchased at huge discounts (varying between 90 and 95% of face value). By revealing the mechanism used by debt-collectors, the paper calls for legislative intervention to seal the gap and ensure adequate taxation of debt-collection activities. The nature of regulatory arbitrage involved relates both to tax law as well as to regulatory standards, such as licensing requirements. Debt buyers benefit from the EU passport rule, make high returns on their ‘investments’ and optimize their taxes on profits obtained. Debt administrators perform their activity at almost no liability and no tax payable to the state. This mechanism creates favorable premises for money laundering and financing of illegal activities, as the web of offshore companies behind the debt-buyer renders the verification of the origin of their investment money extremely difficult. Using Romania as a case study, the paper addresses not only the aforementioned practices and risks, but also the potential reasons behind the state’s inability either to adopt adequate legislation, or to enforce it. In doing so, the paper employs empirical evidence regarding the activity of ten Romanian debt collection agencies and relevant case law thereof. The paper concludes with the authors’ proposal for a potential solution, which can be extended beyond Romania.
Knowledge and Property in John Locke
Authors: Ruiz-Gallardón García De La Rasilla Isabel 
Published: September 2020

Abstract
In this paper, an analysis is performed on the concepts of knowledge and property employed by John Locke to demonstrate the possibility of attaining certainties in moral knowledge and to legitimise private property. His thought was characterised by his desire to trace a connection between the moral, intellectual and material worlds, for the purpose of establishing methodological grounds for a true knowledge of practical principles. Inquiring into the processes of knowledge and into the motivational workings of human behaviour, the English philosopher arrived at the conclusion that thanks to the exercise of his knowledge and will, man acquires, with effort, the ownership of his person and the external world surrounding him, and is capable of attaining knowledge of the content of natural law with a certainty as absolute as that deriving from mathematical knowledge.
A reliable numerical approach for nonlinear fractional optimal control problems
Authors: Singh Harendra , Pandey Rajesh K. , Kumar Devendra 
Published: September 2020

Abstract
In this work, we study a numerical approach for studying a nonlinear model of fractional optimal control problems (FOCPs). We have taken the fractional derivative in a dynamical system of FOCPs, which is in Liouville–Caputo sense. The presented scheme is a grouping of an operational matrix of integrations for Jacobi polynomials and the Ritz method. The proposed approach converts the FOCP into a system of nonlinear algebraic equations, which significantly simplify the problem. Convergence analysis of the scheme is also provided. The presented method is verified on the two illustrative examples to show its accuracy and applicability. Distinct special cases of Jacobi polynomials are considered as a basis to solve the FOCPs for comparison purpose. Further, tables and figures are employed to demonstrate the derived numerical results. The numerical results by the present method are also compared with some other techniques.
Bedeutung und Nutzen der egozentrierten Netzwerkanalyse in der Radikalisierungsforschung
Authors: Möller Veronika 
Published: September 2020

Zusammenfassung
Der vorliegende Beitrag versteht sich explizit als »Werkstattbericht« und fokussiert auf die Erfahrungen aus der Umsetzung des im Rahmen des vom Bundesministerium für Bildung und Forschung geförderten Verbundprojektes »Radikalisierung im digitalen Zeitalter – Risiken, Verläufe und Strategien der Prävention« (RadigZ)1 an der Georg-August-Universität Göttingen durchgeführten Teilprojekts »Experteninterviews mit professionellen Beobachtern; Prognosen«. Integriert in dieses Teilprojekt sind Interviews mit (ehemals) radikalisierten Personen aus dem rechtsradikalen sowie dem salafistisch-jihadistischen Spektrum. Teil dieser Interviews ist die egozentrierte Netzwerkanalyse, welche an den Zeitpunkt zu Beginn der Radikalisierung anknüpft und im Zentrum dieses Beitrages steht.
Laboratory experiment on the nano-TiO2photocatalytic degradation effect of road surface oil pollution
Authors: Wang Qing’e , Zheng Kai , Yu Huanan , Zhao Luwei , Zhu Xuan , Zhang Junqian 
Published: September 2020

AbstractOil leak from vehicles is one of the most common pollution types of the road. The spilled oil could be retained on the surface and spread in the air voids of the road, which results in a decrease in the friction coefficient of the road, affects driving safety, and causes damage to pavement materials over time. Photocatalytic degradation through nano-TiO2is a safe, long-lasting, and sustainable technology among the many methods for treating oil contamination on road surfaces. In this study, the nano-TiO2photocatalytic degradation effect of road surface oil pollution was evaluated through the lab experiment. First, a glass dish was used as a substrate to determine the basic working condition of the test; then, a test method considering the impact of different oil erosion degrees was proposed to eliminate the effect of oil erosion on asphalt pavement and leakage on cement pavement, which led to the development of a lab test method for the nano-TiO2photocatalytic degradation effect of oil pollution on different road surfaces.
Selecting between causal and noncausal models with quantile autoregressions
Authors: Hecq Alain , Sun Li 
Published: September 2020

Abstract
We propose a model selection criterion to detect purely causal from purely noncausal models in the framework of quantile autoregressions (QAR). We also present asymptotics for the i.i.d. case with regularly varying distributed innovations in QAR. This new modelling perspective is appealing for investigating the presence of bubbles in economic and financial time series, and is an alternative to approximate maximum likelihood methods. We illustrate our analysis using hyperinflation episodes of Latin American countries.
A novel splice-site mutation of the HNF1B gene in a family with maturity onset diabetes of the young type 5 (MODY5)
Authors: Fujita Yuki , Tanaka Daisuke , Tatsuoka Hisato , Matsubara Miho , Hyo Takanori , Hamamoto Yoshiyuki , Komiya Toshiyuki , Inagaki Nobuya , Seino Yutaka , Yamazaki Yuji 
Published: September 2020

Summary
Maturity-onset diabetes of the young (MODY) is a form of monogenic diabetes mellitus characterised by early onset and dominant inheritance. Delayed diagnosis or misdiagnosis as type 1 or type 2 diabetes mellitus is common. Definitive genetic diagnosis is essential for appropriate treatment of patients with MODY. The hepatocyte nuclear factor 1-beta (HNF1B) gene is responsible for MODY type 5 (MODY5), which has distinctive clinical features including renal disease. MODY5 should always be considered by clinicians in patients with early onset diabetes and renal anomalies. We report a case of a 30-year-old Japanese male with early-onset diabetes mellitus, renal anomalies and family history of diabetes that was suggestive of MODY5. Renal histology showed no evidence of diabetic nephropathy. Genetic testing revealed a novel heterozygous splice-site mutation of the HNF1B gene in the family members. It was strongly suggested that the mutation could underlie our patient’s MODY5.

Learning points:

Genetic diagnosis of MODY is relevant for appropriate treatment.

Dominantly inherited early-onset diabetes mellitus with renal cysts suggests MODY5.

Scanning the non-coding regions is important for not missing a mutation in HNF1B.
The prognostic value of Tei index in acute myocardial infarction: a systematic review
Authors: Bennett Sadie , Wong Chun Wai , Griffiths Timothy , Stout Martin , Khan Jamal Nasir , Duckett Simon , Heatlie Grant , Kwok Chun Shing 
Published: September 2020

Abstract

Background:Echocardiographic evaluation of left ventricular ejection fraction (LVEF) is used in the risk stratification of patients with an acute myocardial infarction (AMI). However, the prognostic value of the Tei index, an alternative measure of global cardiac function, in AMI patients is not well established.

Methods:We conducted a systematic review, using MEDLINE and EMBASE, to evaluate the prognostic value of the Tei index in predicting adverse outcomes in patients presenting with AMI. The data was collected and narratively synthesised.

Results:A total of 16 studies were including in this review with 2886 participants (mean age was 60 years from 14 studies, the proportion of male patients 69.8% from 14 studies). Patient follow-up duration ranged from during the AMI hospitalisation stay to 57.8 months. Tei index showed a significant association with heart failure episodes, reinfarction, death and left ventricular thrombus formation in 14 out of the 16 studies. However, in one of these studies, Tei index was only significantly predictive of cardiac events in patients where LVEF was <40%. In two further studies, Tei index was not associated with predicting, adverse outcomes once LVEF, left ventricular end-systolic volume index and left ventricular early filling time was taken
into consideration. In the two remaining studies, there was no prognostic value of Tei index in relation to patient outcomes.

Conclusion:Tei index may be an important prognostic marker in AMI patients, however, more studies are needed to better understand when it should be used routinely within clinical practice
Strain-Dependent Modifier Genes Determine Survival inZfp423Mice
Authors: Alcaraz Wendy A , Liu Zheng , Valdes Phoebe , Chen Edward , Valdovino Gonzalez Alan G , Wade Shelby , Wong Cinny , Kim Eunnie , Chen Hsiang-Hua M , Ponn Alison , Concepcion Dorothy , Hamilton Bruce A 
Published: September 2020

AbstractZfp423 encodes a transcriptional regulatory protein that interacts with canonical signaling and lineage pathways. Mutations in mouse Zfp423 or its human ortholog ZNF423 are associated with a range of developmental abnormalities reminiscent of ciliopathies, including cerebellar vermis hypoplasia and other midline brain defects. Null mice have reduced viability in most strain backgrounds. Here we show complete lethality on a C57BL/6J background, dominant rescue in backcrosses to any of 13 partner strains, with strain-dependent survival frequencies, and evidence for a BALB/c-derived survival modifier locus on chromosome 5. Survival data indicate both perinatal and postnatal periods of lethality. Anatomical data from a hypomorphic gene trap allele observed on both C57BL/6J and BALB/c congenic backgrounds shows an aggregate effect of background on sensitivity to Zfp423 loss rather than a binary effect on viability.
Case Report: Serial Topography Analysis After Acute Unilateral Diffuse Lamellar Keratitis
Authors: Lytle Jonathan Jay 
Published: September 2020

Abstract
Significance: Diffuse lamellar keratitis (DLK) is a widely reported complication of laser in-situ keratomileusis (LASIK); however, serial topography tracking the resolution of the condition is sparse. This case illustrates the healing profile which may be expected following an episode of DLK, and the patient reassurances which may be appropriate.
Purpose: To report the topography changes and refractive resolution associated with a case of acute unilateral diffuse lamellar keratitis following bilateral femtosecond-assisted hyperopic LASIK.
Case Report: A healthy 53-year old male presented with grade two-plus diffuse lamellar keratitis (DLK) 11 days after undergoing successful bilateral wavefront optimized (Alcon, Fort Worth, USA), femtosecond-assisted hyperopic LASIK. Resolution of the DLK was achieved in three weeks with topical corticosteroids. Stabilization of the patient’s topography and refractive error was observed two months after the resolution of the DLK.
Conclusions: This case suggests that improvements in corneal topography and refractive error can be expected long after the clinical signs of DLK have subsided. Corneal irregularities and residual refractive errors (usually hyperopia and astigmatism) which exist at the time of resolution on gross examination should be monitored regularly and patients may be reassured that improvements appear likely even after topical regimens have been completed.
Discoloration of Bulk-Fill Versus Conventional Composites: A Spectrophotometric Evaluation
Authors: Serin-Kalay Tugba 
Published: September 2020

Purpose: The purpose of this study was to evaluate the discoloration of a dual-cure bulk-fill (DCBF) and light-cure bulk-fill (LCBF) composites relative to conventional composites (CC) after water and coffee immersion. Methods: One-hundred disc-shaped specimens (8mm in diameter × 4mm thickness) were prepared using five commercially available composites (n=10); two LCBF (XB-X-trafil Voco, FB-FiltekTM Bulk Fill), one DCBF (FU-Fill-upTM Coltene), and two CC (CE-Clearfil Majesty ES2, EQ-Estelite ΣQuick). Initial and final color readouts were measured with a spectrophotometer (Easyshade,Vita) according to the CIELAB color system. Statistical analyses were performed using 2-way ANOVA with Bonferroni adjustment to evaluate ∆E, ∆L, ∆a, and ∆b parameters (p<0.05). Results: Significant interactions were noted among the material types and immersion solutions for all evaluated parameters (p=0.00). ∆E values were observed in the order of FU>FB≥XB>EQ≥CE in water immersion groups and XB>FB>EQ≥FU≥CE in coffee immersion groups. Conclusion: Within the limitations of this study, DCBF composite is more susceptible to intrinsic discoloration compared to LCBF and CC. However, DCBF exhibited lower extrinsic discoloration than LCBF and comparable with CC after coffee immersion. Depending on their chemical and structural compositions, composites will exhibit color change, which compromises the esthetic performance of composite restorations.
Problem Psikis Lansia dan Upaya Mengatasinya Melalui Bimbingan Keagamaan
Authors: Saepah Saepah , Kusnawan Aep , Tajiri Hajir 
Published: September 2020

Penelitian bertujuan untuk : 1) untuk mengetahui keadaan psikis lansia, 2) bimbingan keagamaan, 3) untuk mengetahui hasil bimbingan keagamaan untuk upaya mengatasi problem psikis lansia di Panti Sosial Tresna Werdha Budi Pertiwi. Penelitian ini menggunakan metode deskriptif dengan teknik pengumpulan data bertumpu pada observasi, wawancara dan dokumentasi. Analisis data dilakukan dengan cara mengumpulkan dan menyusun seluruh data yang diperlukan, mengklasifikasikan data-data sesuai dengan jenis masing-masing, setelah itu ditafsirkan dan langkah terakhir di simpulkan. Hasil penelitian menunjukan bahwa : 1) Keadaan psikis lansia disana kurang baik. 2) Adapun bimbingan keagamaan yang dilakukan di Panti Sosial Tresna Werdha Budi Pertiwi ini benar-benar berperan penting untuk upaya mengatasi problem psikis lansia. 3) Hasil bimbingan keagamaan dalam upaya mengatasi problem psikis lansia di Panti Sosial Tresna Werdha Budi Pertiwi ini sangat berperan penting. Dengan bimbingan keagamaan mereka bisa menyelesaikan berbagai permasalahan yang menimpa hidup mereka yang membuat hidup mereka tidak tenang. Dapat disimpulkan bahwa bimbingan keagamaan yang berikan kepada lansia untuk mengatasi problem psikisnya yaitu dengan metode ceramah, hapalan dan bed room. Dalam hal ini dapat dikatakan bahwa bimbingan keagamaan cukup baik dan lancar serta berdampak positif bagi lansia.
The study aims to: 1) to find out the psychological state of the elderly, 2) religious guidance, 3) to find out the results of religious guidance to overcome the psychological problems of the elderly at the Tresna Werdha Budi Pertiwi Social Institution. This research uses descriptive method with data collection techniques based on observation, interviews and documentation. Data analysis is done by collecting and compiling all necessary data, classifying the data according to their respective types, after which they are interpreted and the final step is concluded. The results of the study show that: 1) The psychic condition of the elderly there is not good. 2) The religious guidance carried out at the Tresna Werdha Budi Pertiwi Social Institution really plays an important role in efforts to overcome the psychological problems of the elderly. 3) The results of religious guidance in efforts to overcome the psychological problems of the elderly at the Tresna Werdha Budi Pertiwi Social Institution play an important role. With religious guidance they can solve various problems that befall their lives that make their lives uneasy. It can be concluded that religious guidance is given to the elderly to overcome their psychological problems, namely the lecture method, memorization and bed room. In this case it can be said that religious guidance is quite good and smooth and has a positive impact on the elderly.
Bimbingan Akhlak pada Anak melalui Sistem Halaqah Quran
Authors: Kuswandi Sinta Hajrina , Effendi Dudy Imanuddin , Mujib Abdul 
Published: September 2020

Penelitian ini bertujuan Untuk mengetahui Bimbingan Akhlak pada Anak melalui Sistem Halaqah Quran di SD Al-Quran, untuk mengetahui Faktor Penunjang dan Penghambat Bimbingan Akhlak pada Anak melalui Sistem Halaqah Quran di SD Al-Quran, serta untuk mengetahui hasil yang dicapai dari Bimbingan Akhlak pada Anak melalui Sistem Halaqah Quran di SD Al-Quran. Penelitian ini menggunakan metode deskriptif kualitatif, yaitu menerapkan fenomena sosial atau suatu peristiwa apa adanya. Dari hasil penelitian diperoleh bahwa bimbingan akhlak pada anak melalui sistem Halaqah Quran diketahui berlangsung dengan efektif dan cukup berhasil. Dampaknya dapat dirasakan oleh Guru Al-Quran selaku pembimbing dan orang tua siswa yang melaporkan perubahan akhlak siswa yang diaplikasikan di rumah. Secara pemahaman, siswa sudah mampu memahami bagaimana akhlak yang baik yang harus dilakukan. Diantaranya Akhlak kepada Allah Swt, Akhlak kepada sesama dan Akhlak kepada lingkungan.
This research aims to find out the Moral Guidance in Children through the Halaqah Quran System at SD Al-Quran, to find out the Supporting Factors and Inhibitors of Moral Guidance on Children through the Halaqah Quran System in the Al-Quran Koran. and to find out the results achieved from Moral Guidance on Children through the Halaqah Quran System in the Al-Quran Elementary School. This study uses descriptive qualitative method, which implements social phenomena or event as they are. From the results of the study, it was found that moral guidance in children through the Halaqah Quran system was known to be effective and quite successful. The impact can be felt by Al-Quran Teachers as mentors and parents of students who report students'moral changes applied at home. In understanding, students have been able tounderstand how good morals must be done. Among there are morals to Allah, morality to others, and morals to the environment.