bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated bilateral optic neuritis revealing a Lyme Disease : case report
Authors: LOUIS DE GONZAGUE MIRAY 
Published: April 2020

Optic neuritis (ON) is an inflammation of the optic nerve and one of the most common manifestations of central nervous system involvement caused by various etiologies. Lyme optic neuritis is a rare ocular manifestation of Lyme Disease. We report a case of a 13-year-old male patient, previously healthy, with decreased central visual acuity on his both eyes . On examination, best-corrected visual acuity on both eyes was 0,3 LogMar. Anterior segment biomicroscopy showed no inflammatory signs and the intraocular pressure was normal. A fundus examination performed under mydriasis revealed a swollen optic disk on both eyes confirmed by fluorescein angiography. The cerebrospinal fluid examination and Lyme Disease blood findings were positive. The diagnosis of Lyme disease-related optic neuritis was made. Treated with Ceftriaxone and Doxicycline, there was a vision recovery. We can state that isolated bilateral optic neuritis is uncommon and exceptional especially in children during Lyme disease.
Denshawai and Cromer in the poetry of Ahmad Shawqi
Authors: Al-Rifai Nada Yousuf 
Published: April 2020

Abstract

In the summer of 1906, a group of British Army officers went on a pigeon hunt near the Nile Delta town of Dinshaway. It came as no surprise then, that during the pigeon hunt, an errant gunshot set fire to the village’s wheat supply. Enraged as they watched their precious grain go up in smoke, villagers tried to seize the offending gun and a riot broke out during which several people were hurt and two of the British officers were wounded. As they tried to escape, one officer died from heatstroke. The British response was brutal. Returning in force to the village, a military tribunal convicted 52 of the villagers of pre-meditated murder; though most were just beaten, four were hanged. On April 1, 1907, less than a year after the Denshawai issue, Lord Cromer resigned as governor of Egypt since 1883, and left Egypt. His departure allowed the anger among the patriots, who were critical of him, to be set free, primarily because of his offense to Islam, and because he did not make any sincere effort to try to understand the aspirations of Egyptians. Ahmad Shawqi's "Farewell to Lord Cromer," was composed on the occasion of the latter's departure from Egypt. After his resignation, Lord Cromer gave a farewell speech at the Khedival Opera House in Cairo on May 4, 1907. Cromer's speech provoked a chorus of protest by the nationalists as well as by forces allied with the Khedive whom Shawqi was one of.
The Efficacy of School Inspection and the Quality Teaching-Learning of Students in Lower Secondary Schools in Uganda
Authors: Busingye John 
Published: April 2020

The study evaluated the efficacy of school Inspection upon quality teaching/learning in lower secondary Schools. The study targeted a population of 280 participants selected from twenty (20) schools with a sample size of 203 participants that was investigated. Questionnaires were the main data collection tool used. The study findings show that the geographical location of some schools, lack of enough finances to carry out inspection, bad weather conditions, heavy work load of duties by district inspector of schools and education officers. The study concluded that district education officers and inspector of schools were vital in the teaching learning processes. The study commends that there is need for excellent working relationship between the inspection team and classroom teachers through formal meetings to high light on the progress and challenges related to teaching/learning outcomes. The study further commends government to increase the budget allocated to lower secondary school inspection so as to inspire the inspection activities to be carried out as planned in the education sector.
A Content Analysis of the WH-Questions in the EFL Textbook of That's Right
Authors: Igbaria Abdul Kareem , Ghanayem Asmaa 
Published: April 2020

In the current study, the researchers analyzed the units of the textbook “That’s Right” for 10th grade students for English teaching in Israel. The study examined the WH- questions found in the textbook according to the various cognitive levels of Bloom’s Taxonomy. By using Bloom's taxonomy, the researchers attempted to understand whether WH-questions used in the textbook emphasize high-level thinking and cognitive skills development. The question of this study is: To what extent do the WH-questions in the textbook “That’s Right” emphasize higher order thinking skills?
Content analysis was performed for the questions for five study units in the textbook. The question served as the unit of analysis for this research. A WH-question is defined as a question beginning with a WH-word and ending with a question mark. The questions were collected, listed, and analyzed according to Bloom's taxonomy, according to which thinking skills are divided into low and high orders. Low order thinking skills are knowledge, comprehension, and application. High order thinking skills are: analysis, synthesis, and evaluation. Percentages and frequencies of each cognition level were calculated for each book unit separately and for all the units combined. Validation and reliability checks were performed to validate this study.
The results showed that 245 out of the 324 questions emphasized cognition levels that develop lower order thinking skills, while only 79 questions emphasized the three levels that use high order thinking skills. The textbook "That’s Right" questions place most emphasis on comprehension and knowledge, which are both connected to lower order thinking skills. This may result in lower cognitive abilities among students and should be further investigated to create better language skills in future generations. Additional studies of English textbooks at various age levels using content analysis are recommended. These studies will show which cognitive skills are developed in English materials and will improve future English education in Israel.
The 21st century skills of the female students of practical education in the Department of Kindergartens in Faculty of Education - King Faisal University
Authors: Mohammad Aidah Deep , Hussien Asma Margeni 
Published: April 2020

This study aims at realizing the degree of acquiring the 21st century skills by the female students of practical education in the department of kindergartens at the Faculty of Education in the University ofKing Faisal , and ranking the acquisition of the skills by the female students . To achieve the objectives of the study , the researcher adoptedthe descriptiveanalyticalapproach , andthe application of the study’stool , namely thequestionnaire that consists of ( 40 ) items divided into five skills : 1 . Communication and participation . 2 . Informationculture . 3 . Lifeskills 4 . Learningand creativity . 5 . Emotional intelligence . Afterconfirming its validity and reliability , it was applied to the study’s sample , which consisted of ( 245 ) female students . The results showed that the degreeof acquiring the 21st century skills
by the sample members was very high with an arithmetic mean ( 4 . 38 ) , and with a standard deviation ( 0 . 438 ) . The third field “ life skills “ was in the first place with an arithmetic mean ( 4 . 53 ) and a standard deviation ( 0 . 442 ) with a very high degree . The fourth field “ learning and creativity “ which was in the second place with an arithmetic mean ( 4 . 48 ) and a standard deviation ( 0 . 496 ) with a very high degree . The first field “ communication and participation “ was in the third place with an arithmetic mean ( 4 . 41 ) and a standard deviation ( 0 . 457 ) with a very high degree . The fifth field “ emotional intelligence “ was in the fourth place with an arithmetic average ( 4 . 26 ) and a standard deviation ( 0 . 632 ) with a very high degree . The second field “ information culture “ was in the last place with an arithmetic mean ( 4 . 23 ) and a standard deviation ( 0 . 561 ) with a very high degree . The study recommended the importance of incorporating the 21st century skills into the program for preparing kindergarten teachers , and working on developing professional development programs for the teacher in a way that suits the changesand developments of the current era .
Genome-Wide Changes in Genetic Diversity in a Population of Myotis lucifugus Affected by White-Nose Syndrome
Authors: Lilley Thomas M , Wilson Ian W , Field Kenneth A , Reeder DeeAnn M , Vodzak Megan E , Turner Gregory G , Kurta Allen , Blomberg Anna S , Hoff Samantha , Herzog Carl J , Sewall Brent J , Paterson Steve 
Published: April 2020

Abstract
Novel pathogens can cause massive declines in populations, and even extirpation of hosts. But disease can also act as a selective pressure on survivors, driving the evolution of resistance or tolerance. Bat white-nose syndrome (WNS) is a rapidly spreading wildlife disease in North America. The fungus causing the disease invades skin tissues of hibernating bats, resulting in disruption of hibernation behavior, premature energy depletion, and subsequent death. We used whole-genome sequencing to investigate changes in allele frequencies within a population of Myotis lucifugus in eastern North America to search for genetic resistance to WNS. Our results show low FST values within the population across time, i.e., prior to WNS (Pre-WNS) compared to the population that has survived WNS (Post-WNS). However, when dividing the population with a geographical cut-off between the states of Pennsylvania and New York, a sharp increase in values on scaffold GL429776 is evident in the Post-WNS samples. Genes present in the diverged area are associated with thermoregulation and promotion of brown fat production. Thus, although WNS may not have subjected the entire M. lucifugus population to selective pressure, it may have selected for specific alleles in Pennsylvania through decreased gene flow within the population. However, the persistence of remnant sub-populations in the aftermath of WNS is likely due to multiple factors in bat life history.
Sustained Carbohydrate Antigen 19-9 Response to Neoadjuvant Chemotherapy in Borderline Resectable Pancreatic Cancer Predicts Progression and Survival
Authors: Rose J. Bart , Edwards Alicia M. , Rocha Flavio G. , Clark Carolyn , Alseidi Adnan A. , Biehl Thomas R. , Lin Bruce S. , Picozzi Vincent J. , Helton W. Scott 
Published: April 2020

Abstract

Background
As neoadjuvant therapy of borderline resectable pancreatic cancer (BRPC) is becoming more widely used, better indicators of progression are needed to help guide therapeutic decisions.

Materials and Methods
A retrospective review was performed on all patients with BRPC who received 24 weeks of neoadjuvant chemotherapy. Patients with chemotoxicity or medical comorbidities limiting treatment completion and nonexpressors of carbohydrate antigen 19-9 (CA19-9) were excluded. Serum CA19-9 response was analyzed as a predictor of disease progression, recurrence, and survival.

Results
One hundred four patients were included; 39 (37%) progressed on treatment (18 local and 21 distant) and 65 (63%) were resected (68% R0). Multivariate logistic regression analysis determined that the percent decrease in CA19-9 from baseline to minimum value (odds ratio [OR] 0.947, p ≤ .0001) and the percent increase from minimum value to final restaging CA19-9 (OR 1.030, p ≤ .0001) were predictive of progression. A receiver operating characteristics curve analysis determined cutoff values predictive of progression, which were used to create four prognostic groups. CA19-9 responses were categorized as follows: (1) always normal (n = 6); (2) poor response (n = 31); (3) unsustained response (n = 19); and (4) sustained response (n = 48). Median overall survival for Groups 1–4 was 58, 16, 20, and 38 months, respectively (p ≤ .0001).

Conclusion
Patients with initially elevated CA19-9 levels who do not have a decline to a sustained low level are at risk for progression, recurrence, and poor survival. Alternative treatment strategies prior to an attempt at curative resection should be considered in this cohort.
Determination of adaptation levels and applications for fistulas care and protection to disease of patients with arteriovenous fistula
Authors: Atik Derya , Güngör Songül 
Published: April 2020

Introduction: The aim of this study was to the determinate adaptation to chronic disease and applications for arteriovenous fistula (AVF) care and protection of hemodialysis (HD) patients with an AVF, and to determine the relationships between adaptation and application.
Methods: This research is a prospective, descriptive, and cross-sectional type of research. The universe of the study accounted for 180 patients who underwent HD. The research was completed with 114 patients. The research was conducted from July 2019 to September 2019, in two different dialysis centers in Osmaniye Province. The data were collected using The Patient Identification Form and Adaptation to Chronic Illness Scale. Mean ± Standard deviation, percentages, and independent samples t-test analysis were used.
Results: When the scale scores of the patients participating in the study were evaluated, determined to level of total adaptation with chronic disease and physical adaptation was to above the average score (40.24 ± 5.99). Social adaptation (21.82 ± 6.39) and psychological adaptation (22.91 ± 5.39) levels can be said to be moderate. Individuals who exercised with the ball to mature the fistula, who was careful to dress and keep the area dry on the 1st day of the operation, who was careful not to apply lotion to the fistula area, and who complied with the fluid restriction were found to have higher levels of adaptation with the disease.
Conclusion: It can be said that the patients who make the right application for fistula care and protection have in general adaptation levels can also be said to be high. The level of adaptation is effective for applications. The level of adaptation is effective on applications for AVF care and protection.
Possibilities for surgical treatment of the pharmacoresistant form of epilepsy using robot-assisted implantation of deep electrodes for invasive stereoelectroencephalography
Authors: Zuev A. A. , Golovteev A. L. , Pedyash N. V. , Kalybaeva N. A. , Bronov O. Yu. 
Published: April 2020

The study objectiveis to determine the effectiveness, safety and information content of robot-assisted implantation of deep electrodes for invasive stereoelectroencephalography (stereo-EEG) monitoring in patients with pharmacoresistant epilepsy.Materials and methods.The study group included 27 patients from 2016 and 2018, who underwent a robot-assisted implantation of stereo-EEG electrodes followed by a 24-hour video-EEG monitoring. Unilateral implantation of electrodes was performed in 22 patients, bilateral – in 6 patients (in 1 patient, due to the ineffectiveness of the operation to remove the epileptogenic focus, implantation was performed twice). MRI-negative epilepsy was in 16 (59 %) patients; 11 (41 %) patients with multiple structural changes. The average time for invasive video-EEG monitoring was 96 hours (from 46 to 253 hours).Results.Based on the information obtained during invasive monitoring, the epileptogenic zones and early distribution were verified: in the temporal lobe in 9 (33 %) patients, in the frontal lobe – 6 (22 %), in the parietal lobe – 2 (8 %), in the occipital lobe – 3 (11 %), in more than 2 lobes – 4 (15 %), in both hemispheres – 3 (11 %) patients. Nineteen (70.4 %) patients underwent surgery to remove the epileptogenic zone. In 11 (58 %) patients extratemporal resection was performed and 8 (42 %) patients underwent anterior-medial temporal and amygdal-hippocampectomy. Follow-up history of more than 6 months after removal of the epileptogenic zone detected by stereo-EEG was monitored in 13 patients. The outcomes of surgical resection were as follows: in 8 (61 %) patients – Engel I, in 1 (8 %) – Engel II, in 3 (23 %) – Engel III, in 1 (8 %) – Engel IV.Conclusion.Robot-assisted implantation of deep electrodes for invasive stereo-EEG monitoring is a safe and effective diagnostic method in patients with pharmacoresistant epilepsy. In patients with MRI-negative epilepsy, stereo-EEG allows to localize and determine the boundaries of the epileptogenic zone, thereby increasing the effectiveness and safety of surgical resection.
Radiofrequency neurotomy of the sacroiliac joints in the treatment of chronic lumbosacral pain
Authors: Evzikov G. Yu. , Belozerskikh K. A. , Egorov O. E. , Parfenov V. A. 
Published: April 2020

The study objectiveis to compare the effectiveness of different methods of radiofrequency denervation of the sacroiliac joint (SJ): standard neurotomy (SN) of the posterior medial branch L5and lateral branches S1–S3, ligamentous neurotomy (LN) and a combination of ligamentous and standard methods – a combined neurotomy (CN).Materials and methods.The results of the treatment of 311 patients with SJ dysfunction were analyzed. LN was perfomed in 117 patients, SN – in 102, CN – in 92. The effectiveness of SJ neurotomy was assess using the visual-analog scale (WAS) and the Oswestry Disability Index (ODI) 3 days, 3, 6 and 12 months or more after denervation.Results.The most significant improving the patient’s condition occurred after CN, the average ODI decreased from 35.14 ± 7.49 before the intervention to 22.64 ± 10.26 a year after it (p = 0.006). After SN and LN, a decrease in the degree of maladaptation occurred, respectively, from 36.00 ± 7.32 to 28.08 ± 7.03 (p = 0.021) and from 34.50 ± 6.75 to 26.45 ± 7.18 (p = 0.018). The intensity of the pain syndrome according to WAS after CN decreased from 7.2 ± 2.0 to 3.6 ± 2.5 a year after denervation (p = 0,00024). After SN and LN, a decrease in pain intensity according to WAS occurred respectively from 7.2 ± 2.0 to 4.8 ± 2.3 (p = 0.0025) and from 7.1 ± 2.3 to 5.7 ± 2.5 (p = 0.00016) a year after denervation.Conclusion.All methods of denervation in case of defeat of SJ lead to a statistically significant decrease in pain syndrome and an improvement in the quality of life. A positive result of denervation persists for a year after the intervention. CN leads to a more significant improvement and its results exceed the results of SN and LN for most of the period of postoperative observation.
Gamma Knife radiosurgical treatment of a dural arteriovenous fistula with the feeding branches from the meningo-pituitary trunks of both internal carotid arteries
Authors: Tokarev A. S. , Rak V. A. , Gretskikh K. V. , Evdokimova O. L. , Viktorova O. A. 
Published: April 2020

Treatment strategies for dural arterio-venous fistulas (DAFs) include single or multimodal schemes, including microsurgery, endovascular transarterial or transvenous embolization, or stereotactic radiosurgery (SRS).In the scientific medical resources, only 9 cases of bilateral DAFs of the brain are described, which required surgical intervention, and 4 were treated with endovascular or microsurgical approach; SRS was used in 5 cases, of which in 4 cases with previous or subsequent endovascular embolization.We have presented a case of successful SRS with Gamma Knife of bilateral DAF from the branches of meningo-hypophyseal trunks from inner carotid arteries without preliminary embolization or surgical resection.The use of SRS with Gamma Knife is possible with low-flow DAFs, as well as a part of a multimodal strategy with high-flow DAFs, which requires further study.
Endovascular embolization of the left middle meningеal artery for residual chronic subdural hematoma (clinical case)
Authors: Paskhin D. L. , Pak V. V. , Mironkov A. B. , Asratyan S. А. , Shurygin S. N. 
Published: April 2020

The objective is to describe the case of successful endovascular treatment of residual chronic subdural hematoma.Clinical case. Patient A., 77 years old, was admitted to the hospital with a directional diagnosis of stroke. During further examination, left hemispheric chronic subdural hematoma with a volume of 100 cm3 was revealed. The patient was twice performed closed external drainage of hematoma. And for each subsequent control computed tomography studies, a residual hematoma with a volume effect on the brain was determined. Endovascular selective embolization of the left middle meningеal artery was performed. During the examination after 5 months, a complete reduction of hematoma, cerebral and focal neurological symptoms was noted.Conclusion. Endovascular embolization of the middle meningeal artery may be a pathogenetically substantiated, minimally invasive alternative to repeated surgical interventions for residual and recurrent chronic subdural hematoma. It will be reasonable to continue research to assess the effectiveness and safety of the methodology.
Facial pain, caused by Torkildsen shunt migration
Authors: Bervitskiy A. V. , Moysak G. I. , Dmitriev A. B. , Rzaev D. A. 
Published: April 2020

Introduction. The literature showed a limited number of cases of facial pain caused by pathology at the level of the craniovertebral junction, however there is no a single case of pain caused by the migration of elements of the shunt systems.The objective is to describe a clinical case of successful surgical treatment of facial pain caused by the Torkildsen shunt migration.Clinical case. A female patient, 58 years old, applied to the clinic complaining of constant pain with a paroxysmal component in the left part of the face and back of the skull associated with head movements. Other complaints included a headache accompanied by nausea, numbness in the limbs, instability in vertical position, urinary incontinence, abnormal proprioceptive sensitivity in the limbs. Medical history showed that in 2000 the patient underwent Torkildsen procedure (ventriculo-cisternostomy) due to occlusive hydrocephalus after a neurological infection. In 2013, due to shunt dysfunction endoscopic third ventriculostomy was performed with a good clinical effect. Deterioration started in January of 2018. At hospitalization, tomography of the brain showed migration of the distal end of the shunt into spinal matter, syringobulbia at the C1 vertebra level. No signs of neurovascular conflict of the trifacial nerves were observed. Removal of the ventriculo-cisternal shunt irritating the spinal nucleus of the trifacial nerve was performed. In the postoperative period, intensity of the paroxysmal component of facial pain decreased. At day 5 after surgery, the patient was discharged in a satisfactory state. For 1 year and 6 months after the surgery, facial pain has been absent. Manifestations of hydrocephalus and spinal disorder (numbness of the limbs, instability, urinary incontinence) persist, but due to the patient’s compensated state, negative result of the tap-test, signs of functional third ventriculostomy, it was decided to abstain from further interventions.Conclusion. This clinical case demonstrated successful treatment of facial pain developed due to a rare cause – migration of a Torkildsen shunt that currently is rarely encountered.