bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Effectiveness and Safety of Infliximab, Golimumab and Golimumab-IV in Rheumatoid Arthritis Patients from a Canadian Prospective Observational Registry
Authors: Rahman Proton , Baer Philip , Keystone Ed , Choquette Denis , Thorne Carter , Haraoui Boulos , Chow Andrew , Faraawi Rafat , Olszynski Wojciech , Kelsall John , Rampakakis Emmanouil , Lehman Allen J. , Nantel Francois 
Published: February 2020

Abstract
Background Long-term clinical registries are essential tools to evaluate new therapies in a patient population that differs from those in randomized clinical trials. The objectives are to describe the profile of rheumatoid arthritis (RA) patients treated with anti-TNF agents in Canadian routine care. Methods RA patients eligible for treatment with Infliximab (IFX), golimumab (GLM) or intravenous golimumab (GLM-IV) as per their respective Canadian product monographs were enrolled into the BioTRAC registry between 2002 and 2017. Study visits occurred at baseline and every 6 months thereafter. Effectiveness was assessed by changes in disease activity. Safety was evaluated by the incidence of adverse events (AEs) and drug survival. Results Of the 890 IFX-, 530 GLM-SC- and 157 GLM-IV-treated patients, the proportion of females ranged from 77.0-86.6%, the mean ages from 55.8-57.7 and the mean disease duration from 6.5-8.6 years. A significant decrease in baseline disease duration and disease activity parameters (DAS, TJC, SJC, HAQ, AM stiffness, MDGA, PtGA, CRP, ESR) was observed over time. Treatment with IFX, GLM-SC and GLM-IV significantly improved all disease parameters over time. The incidence of AEs was 105, 113 and 82.6 /100 PYs and the incidence of SAEs was 11.7, 11.2 and 4.68 /100 PYs for IFX, GLM-SC and GLM-IV-treated patients, respectively. Conclusion Differences in baseline characteristics between patients treated with an anti-TNFs over time shows the evolution of treatment modalities over time. All treatments significantly reduced disease activity and improved functionality in a similar fashion. The incidence of adverse events was consistent with the safety profiles of IFX and GLM.
Circular RNA hsa_circ_102209 promotes the growth and metastasis of colorectal cancer through miR-761-mediated Ras and Rab interactor 1 signaling
Authors: LI CHI , Zhou Hong 
Published: February 2020

Abstract
Background: The levels of hsa_circ_102209 in colorectal cancer (CRC) specimens and cells, as well as its effects on CRC cells were investigated. Methods: The expression of hsa_circ_102209 in CRC and paired non-cancerous samples, human CRC and normal colonic epithelial cells were examined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Cells with hsa_circ_102209 knockdown were established using lentiviral vectors. Cell proliferative ability was evaluated using CCK-8 assay; cell migration and invasion were assessed by wound healing and Transwell assay. Cell cycle arrest and apoptosis were determined; apoptosis and EMT markers were examined using RT-qPCR and western blotting. Tumour development and levels of associated proteins were determined in hsa_circ_102209 knockdown mice. Results: Our results revealed that expression of hsa_circ_102209 was remarkably increased in CRC tissues, where the levels of miR-761 were notably reduced (p<0.05). Additionally, the levels of hsa_circ_102209 was associated with histology grade and occurrence of liver metastasis in CRC patients, and the expression of hsa_circ_102209 and miR-761 were negatively correlated (p<0.05). Moreover, hsa_circ_102209 was upregulated in CRC cells compared with normal colonic epithelial cells. Knockdown of hsa_circ_102209 notably inhibited the proliferation, migration, invasion and EMT of CRC cells (p<0.05), whereas enhanced cell cycle arrest at G0/G1 phase and apoptosis (p<0.05). Furthermore, miR-761/Ras and Rab interactor 1 (RIN1) axis was the putative target of hsa_circ_102209 in CRC and involved in hsa_circ_102209-modulated growth and metastasis in CRC cells (p<0.05). Knockdown of hsa_circ_102209 also remarkably suppressed tumor growth in vivo (p<0.05). Conclusions: our data revealed that the expression of hsa_circ_102209 was elevated in CRC samples and cells. Furthermore, hsa_circ_102209 could promote the progression of CRC through miR-761/RIN1 axis. More importantly, hsa_circ_102209/miR-761/RIN1 signaling may be a novel therapeutic target for the treatment of CRC patients.
Serum ErbB2 concentration positively correlated to the glycemic variations in newly diagnosed Type 2 diabetic patients
Authors: Huang Yan , Han Xia , Li Feng-fei , Liu Yan-mei , Liu Zelong , She Yu-qing 
Published: February 2020

Abstract
Background Accumulated evidences indicate that elevated levels of circulating ErbB2 are closely associated with increased incidence of diabetes. However, the relationship between ErbB2 concentration and glycemic variations (GV) in type 2 diabetic (T2D) patients remains elucidated. The aim of this study was to assess whether there is an association between serum ErbB2 concentration and GV in newly diagnosed T2D patients. Methods This was a three-center, and observational study. Between April 2019 and July 2019, a total of 106 newly diagnosed T2D patients were recruited. All recruited subjects were admitted as inpatients and received anti-diabetes agents free during the study period. At baseline, fasting serum was collected for ErbB2 measurement and all recruited patients were subjected a prospective CGM for at least 3 days. The primary endpoint was the relationships between ErbB2 concentrations and GV in T2D patients. Results Data of a total of 95 subjects who met the inclusion criteria were analyzed at the endpoint. Subjects were divided into quartiles according to their serum ErbB2 concentrations. We observed that subjects with an elevated level of ErbB2 had a higher value of GV in terms of mean amplitude of glucose excursion (MAGE), standard deviation of mean glucose (SDMG), and the coefficient of variation (CV%) than those with lower levels (all P<0.05). Multiple linear regression analyzes after adjusting for confounder factors indicate that serum ErbB2 levels were significantly positively correlated with the MAGE (β=0.664, t=7.218, P<0.01), SD (β=0.469, t=5.125, P<0.01) and CV% (β=0.337, t=4.442, P<0.01), respectively. Conclusion Serum ErbB2 concentration was positively correlated to the glycemic variations in newly diagnosed T2D patients. Our data indicating that ErbB2 may be a potential treatment target for diabetic patients for improvement in glycemic control. Keywords Type 2 Diabetes, glycemic control, ErbB2
Improved technology for new-generation Kazakh national meat products
Authors: Uzakov Yasin , Kaldarbekova Madina , Kuznetsova Olga 
Published: February 2020

Introduction. Extract of goji berries (Lycium Barbarum L.) and buckwheat flour (Fagopýrum esculéntum L.) possess antioxidant and antimicrobial properties. As a result, they can be used to improve traditional Kazakh horse-meat formulations to obtain functional cooked and smoked meat products. These natural biologically active substances can improve the oxidative stability of pigments, lipids, and proteins of finished products. The research objective was to assess the potential of goji extract and buckwheat flour as additives that can improve the oxidative stability and general quality of Kanagat, a national Kazakh cooked and smoked horse-meat product. Goji extract and buckwheat flour were used in two concentrations – 0.5% and 1.0%.
Study objects and methods. The research featured sensory evaluation of taste, smell, color, determination of color parameters (L*, a*, b*), pH, free amine nitrogen, total carbonyl proteins, acid value, peroxide value and thiobarbituric acid reactive substances (TBARS), as well as a histological analysis.
Results and discussion. When 1.0% of goji extract and 1.0% of buckwheat flour were added to the traditional formulation, it improved the oxidative stability and quality of the modified horse-meat product while preserving its sensory properties and colour parameters. A set of microstructural studies showed that the processing of meat products with 1.0% of goji extract and 1.0% of buckwheat flour had a destructive effect on most fibers. The affected fibers showed multiple decays of myofibrillar substance, which turned into a finegrained protein mass. The abovementioned concentration caused effective inhibition of hydrolytic changes, as well as oxidation of proteins and lipids.
Conclusion. The new technology made it possible to produce a new national horse-meat product fortified with 1.0% of goji extract and 1.0% of buckwheat flour. The specified amount of biologically active additives improved the oxidative stability and quality of the product, while maintaining its sensory and color characteristics.
A CFD strategy to retrofit an anaerobic digester to improve mixing performance in wastewater treatment
Authors: Dapelo D. , Bridgeman J. 
Published: February 2020

Abstract
To date, mixing design practice in anaerobic digestion has focussed on biogas production, but no adequate consideration has been given to energy efficiency. A coherent, comprehensive and generalized strategy based on computational fluid dynamics (CFD) modelling is proposed to improve mixing efficiency of a full-scale, unconfined gas-mixed digester for wastewater treatment. The model consists of an Euler–Lagrange (EL) model where biogas bubbles are modelled as the Eulerian dispersed phase, and non-Newtonian sludge as the Lagrangian continuous phase. Robustness tests show that mixing predictions are independent of bubble size. The CFD strategy comprises the assessment of different mixing geometries and a range of input gas flow rates. Quantitative results show that simple retrofitting measures are able to achieve a significant improvement in the degree of mixing with reduced mixing times, and consequently recommendations for best mixing geometry and gas flow rate are given. A generalization to a generic digester is discussed in a form that is readily usable by professionals and consultants.
Lignans and Neolignans Anti-tuberculosis Identified by QSAR and Molecular Modeling
Authors: S. Maia Mayara , de Sousa Natália F. , Rodrigues Gabriela C.S. , Monteiro Alex F.M. , Scotti Marcus T. , Scotti Luciana 
Published: February 2020

Background:
Tuberculosis is a disease with high incidence and high mortality rate,
especially in Brazil. Although there are several medications available for treatment, in cases of
resistance, there is a need to use more than one medication.

Objective:
Therefore, cases of toxicity increase and reports of resistance have been worrying the
population. In addition, some medications have a short period of effectiveness. To achieve the
goal, ligand-based and structure-based approaches were used.

Methods:
Thus, in an attempt to discover potent inhibitors against Mycobacterium tuberculosis
enzymes, we sought to identify natural products with high therapeutic potential for the treatment of
Tuberculosis through QSAR, Molecular Modeling and ADMET studies.

Results:
The results showed that the models generated from two sets of molecules with known
activity against M. tuberculosis enzymes InhA and PS were able to select 11 and 8 compounds,
respectively, between Lignans and Neolignans with 50 to 60% activity probability. In addition,
molecular docking contributed to confirm the mechanism of action of compounds and increase the
accuracy of methodologies. All molecules showed higher binding energy values for the drug
Isoniazid. We conclude that compounds 33, 34, 110, 114 and 133 are promising for InhA target
and compounds 07, 08, 19, 21, 42, 48, 75 and 141 for target PS. In addition, most molecules did
not show any toxicity according to the evaluated parameters.

Conclusions:
Therefore, Lignans and Neolignans may be an alternative for the treatment of
Tuberculosis.
Biological Activities and Phenolic Compound Content of Astilboides tabularis (Hemsl.) Engler Extracts
Authors: Yang Jinfeng , Chanok Lee , Heekyu Kim , Kwon Yong S. , Kim Myong J. 
Published: February 2020

Introduction:The plant, Astilboides tabularis (Hemsl.) Engler, is used in Chinese and Korean medicine to regulate blood sugar levels; however, little is known about its precise effects.Materials and Methods:In this study, we aimed to measure the composition as well as the antioxidant, and anti-proliferative capacities of A. tabularis. Various extracts were generated using different organic solvents, and in vitro antioxidant activities were evaluated using DPPH free radical-scavenging and reducing power assays. The extracts were also evaluated based on their ability to inhibit lipopolysaccharide (LPS)-induced Nitric Oxide (NO) production in RAW 264.7 cells.Results:Research shows that the A. tabularis ethyl acetate (EtOAc) extract showed significant antioxidant activity. Additionally, this extract could inhibit the LPS-induced expression of inflammatory mediators and pro-inflammatory cytokines in RAW 264.7 cells, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and interleukin-1 beta (IL-1ß). Notably, the A. tabularis EtOAc extract also displayed potent cytotoxic effects against MCF-7 and HeLa cancer cell lines, as determined by MTT assays. Lastly, total phenol and flavonoid content was measured for all extracts, and four flavonoid compounds-catechin, kaempferol, quercitrin, and isoquercetin were isolated from the EtOAc extract. Their structures were confirmed using mass spectrometry and nuclear magnetic resonance, and these isolated compounds were found to display potent DPPH free radical-scavenging activity.Conclusion:Thus, our data suggest that phenolic compounds in A. tabularis extracts promote antioxidant activity, and furthermore, these extracts show numerous features that indicate potential for therapeutic development.
Efficient Methods for the Synthesis of Novel Arylazothiazoles Based on Acetylferrocene or Adamantane
Authors: Sayed Abdelwahed R. , Ahmed Mohamed S.M. , Gomha Sobhi M. 
Published: February 2020

Background:Hydrazonoyl halides are convenient for the synthesis of arylazothiazoles.Materials and Methods:A series of novel arylazothiazoles were efficiently synthesized from the reaction of hydrazonoyl chlorides with 2-(adamantan-2-ylidene)hydrazinecarbothioamide or 2-(ferrocenyl-1-ylidene)hydrazinecarbo-- thioamide in dioxane used as an aprotic solvent because of its lower toxicity and higher boiling point (101 °C) and triethylamine at reflux. The reaction mechanistic pathway proceeded by the nucleophilic substitution reaction by the elimination of hydrogen chloride to give thiohydrazonates as intermediate, which in situ undergo intramolecular cyclization and loss of water molecule to afford the final product of novel arylazothiazoles. This method is simple with good yield and excellent purities.Results and Discussion:The synthetic schemes for the final products are proposed and discussed. The chemical structures of the final products were identified by different techniques, such as elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS).Conclusion:In this article, we prepared arylazothiazoles from the reaction of 2-(adamantan-2-ylidene)hydrazinecarbothioamide or 2-(ferrocenyl-1-ylidene)hydrazinecarbothioamide with hydrazonoyl halides.
Structures and Absorption Spectrum of 1D and 2D ZnS Nanoparticles
Authors: Papantzikos Spyros , Chronis Alexandos G. , Michos Fotios I. , Sigalas Mihail M. 
Published: February 2020

Background:
ZnS nanoparticles (NPs) are attractive for quantum dots
applications because they consist of abundant and non-toxic elements. Their major
drawback is that they absorb in the UV region, ultimately limiting their
applications.

Objective:
In the present study, 1D and 2D ZnS NPs have been found. The goal of
this study is to find NPs that have absorption in the visible spectrum.

Methods:
Calculations based on the Density Functional Theory (DFT) have been
used to find the optimized geometries. Their absorption spectra have been
calculated with the Time-Dependent DFT.

Results:
Several shapes were examined, such as nanorod, and it is observed that
these shapes move the absorption spectra in lower energies, into the visible
spectrum, while the 3D NPs have absorption edges in the UV region.

Conclusion:
NPs with the shape of nanorod in different directions showed that their
absorption spectra moved to lower energies well inside the visible spectrum with
significantly high oscillator strength. In contrast with the mostly used CdSe NPs,
the ZnS NPs are made from more abundant and less toxic elements. Therefore, by
making them absorb in the visible region, they may find significant applications in
solar cells and other photonic applications.
Low-Cost Consumer-Based Trackers to Measure Physical Activity and Sleep Duration Among Adults in Free-Living Conditions: Validation Study
Authors: Degroote Laurent , Hamerlinck Gilles , Poels Karolien , Maher Carol , Crombez Geert , De Bourdeaudhuij Ilse , Vandendriessche Ann , Curtis Rachel G , DeSmet Ann 
Published: February 2020

Background
Wearable trackers for monitoring physical activity (PA) and total sleep time (TST) are increasingly popular. These devices are used not only by consumers to monitor their behavior but also by researchers to track the behavior of large samples and by health professionals to implement interventions aimed at health promotion and to remotely monitor patients. However, high costs and accuracy concerns may be barriers to widespread adoption.

Objective
This study aimed to investigate the concurrent validity of 6 low-cost activity trackers for measuring steps, moderate-to-vigorous physical activity (MVPA), and TST: Geonaut On Coach, iWown i5 Plus, MyKronoz ZeFit4, Nokia GO, VeryFit 2.0, and Xiaomi MiBand 2.

Methods
A free-living protocol was used in which 20 adults engaged in their usual daily activities and sleep. For 3 days and 3 nights, they simultaneously wore a low-cost tracker and a high-cost tracker (Fitbit Charge HR) on the nondominant wrist. Participants wore an ActiGraph GT3X+ accelerometer on the hip at daytime and a BodyMedia SenseWear device on the nondominant upper arm at nighttime. Validity was assessed by comparing each tracker with the ActiGraph GT3X+ and BodyMedia SenseWear using mean absolute percentage error scores, correlations, and Bland-Altman plots in IBM SPSS 24.0.

Results
Large variations were shown between trackers. Low-cost trackers showed moderate-to-strong correlations (Spearman r=0.53-0.91) and low-to-good agreement (intraclass correlation coefficient [ICC]=0.51-0.90) for measuring steps. Weak-to-moderate correlations (Spearman r=0.24-0.56) and low agreement (ICC=0.18-0.56) were shown for measuring MVPA. For measuring TST, the low-cost trackers showed weak-to-strong correlations (Spearman r=0.04-0.73) and low agreement (ICC=0.05-0.52). The Bland-Altman plot revealed a variation between overcounting and undercounting for measuring steps, MVPA, and TST, depending on the used low-cost tracker. None of the trackers, including Fitbit (a high-cost tracker), showed high validity to measure MVPA.

Conclusions
This study was the first to examine the concurrent validity of low-cost trackers. Validity was strongest for the measurement of steps; there was evidence of validity for measurement of sleep in some trackers, and validity for measurement of MVPA time was weak throughout all devices. Validity ranged between devices, with Xiaomi having the highest validity for measurement of steps and VeryFit performing relatively strong across both sleep and steps domains. Low-cost trackers hold promise for monitoring and measurement of movement and sleep behaviors, both for consumers and researchers.
Penguatan Pendidikan Karakter Berbasis Nilai-Nilai Kearifan Lokal di Sekolah
Authors: Iswatiningsih Daroe 
Published: February 2020

Pendidikan karakter sampai saat ini masih perlu ditanamkan pada siswa dalam pembelajaran. Pendidikan karakter diharapkan mampu menguatkan lima nilai utama karakter, yakni nilai religius, nasionalis, mandiri, gotong royong, dan integritas. Dalam penguatan pendidikan karakter di sekolah dapat dilakukan melalui pendidikan budaya berkearifan lokal. Budaya kearifan lokal perlu dikenalkan dan diajarkan di sekolah agar menumbuhkan sikap cinta budaya. Para siswa saat ini kurang memiliki sikap peduli dan mencintai budaya. Untuk itu, paparan berikut menjelaskan bagaimana mengimplementasikan pendidika karakter berbasis kearifan lokal.
Nota de retractación
Authors: Nino-Munoz Diana 
Published: February 2020

Retractación de: Neuroaprendizaje, una propuesta educativa: herramientas para mejorar la praxis del docente. Pherez, G., Vargas, S., y Jerez, J. (Vol. 18 No. 34, 2018, pp. 149-166). doi: 10.22518/usergioa/jour/ccsh/2018.1/a10
How Does Information Processing Efficiency Relate to Investment Efficiency? Evidence from XBRL Adoption
Authors: Cheng Xin , Huang Feiqi , Palmon Dan , Yin Cheng 
Published: February 2020

ABSTRACT
This study investigates whether information processing efficiency has an impact on public companies' investment efficiency. Using the adoption of XBRL as an exogenous shock that decreases information processing cost, we find that companies improve their investment efficiency after the adoption of XBRL. The effect is more pronounced for (1) firms that have inferior external monitoring, (2) firms that operate in more uncertain information environments, and (3) firms that have less readable financial reporting. In addition, we find a learning curve in investors' understanding of XBRL over time. After splitting firms into over-investment and under-investment groups, we conclude that the XBRL mandate is more likely to curb managers' opportunistic over-investments. Our study extends the XBRL literature by providing empirical evidence on the effects of XBRL adoption from the perspective of managers.
Data Availability: Contact the corresponding author at yincheng@sem.tsinghua.edu.cn.
An Improved Direct Injection Technique With Flowable Composites. A Digital Workflow Case Report
Authors: Coachman C , De Arbeloa L , Mahn G , Sulaiman TA , Mahn E 
Published: February 2020

SUMMARY
This article presents a clinical technique based on a case report for restoring the contours and shape of the upper teeth involved in the smile display of a young patient. After planning the treatment for the patient using digital tools (Digital pictures, Digital Smile Design, digital waxup, three-dimensional [3D] printed models, mockup), the upper teeth were restored using an improved injection technique. This improved technique involves the direct injection of flowable composite resin using clear polyvinyl siloxane molds made from 3D-printed models of the patient. The details and benefits of this new technique are described in the article.