bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crizotinib vs platinum‐based chemotherapy as first‐line treatment for advanced non‐small cell lung cancer with different ROS1 fusion variants
Authors: Xu Haiyan , Zhang Quan , Liang Li , Li Junling , Liu Zhefeng , Li Weihua , Yang Lu , Yang Guangjian , Xu Fei , Ying Jianming , Zhang Shucai , Wang Yan 
Published: March 2020

AbstractBackgroundROS1 gene fusion represents a specific subtype of non‐small cell lung cancer (NSCLC). Crizotinib is recommended for ROS1‐positive NSCLC due to its favorable outcome in published clinical trials. However, due to the low incidence of ROS1‐positive NSCLC, there is limited information on real‐world clinical outcomes in patients treated with either crizotinib or platinum‐based doublet chemotherapy.MethodsOutcomes were recorded in 102 patients with stage Ⅲb or Ⅳ NSCLC who were treated at four Chinese hospitals between April, 2010 and June, 2019.ResultsOf the 102 patients followed, 71.6% were females, 81.4% were non‐smokers, and 98.0% had adenocarcinoma. First‐line treatment with crizotinib achieved a significantly longer median progression‐free survival (PFS) compared with platinum‐based chemotherapy (14.9 months vs 8.5 months, respectively; P < .001). Next‐generation sequencing (NGS) identified 61 patients who had ROS1 fusion variants, including CD74 (n = 33) and non‐CD74 (n = 28) variants. In patients harboring CD74 fusion variants, the median PFS with first‐line crizotinib treatment was significantly longer than in those harboring non‐CD74 fusion variants (20.1 months vs 12.0 months, respectively; P = .046). However, in patients treated with platinum‐based chemotherapy, there was no significant difference in PFS between the CD74 and non‐CD74 variant groups (8.6 months vs 4.3 months, respectively; P = .115). Overall survival (OS) was not reached.ConclusionsFirst‐line therapy with crizotinib is more beneficial than platinum‐based chemotherapy in patients with advanced NSCLC with different ROS1 fusion variants. Patients harboring CD74 fusion variants appear to respond better to crizotinib.
Intestinal necrosis after co‐administration of sodium polystyrene sulfonate and activated charcoal
Authors: Singhania Namrata , Al‐Odat Raman , Singh Anil K. , Al‐Rabadi Laith 
Published: March 2020

AbstractDevelopment of acute abdominal pain after Kayexalate and activated charcoal administration should prompt clinician to consider intestinal necrosis. Concomitant use should be avoided to minimize the risk of this devastating but preventable condition.
Can CSF spectrophotometry for “Xanthochromia” be used to detect leaking subarachnoid aneurysms in patients with sickle cell anemia with negative MRI or CT angiogram despite hyperbilirubinemia?
Authors: Siu Wan Yung , Thomas William , Trivedi Rikin , Hogan Alexandra , Siddiqi Umbareen , Sarker Anita , Besser Martin Wolfgang 
Published: March 2020

AbstractCSF (Cerebrospinal Fluid) xanthochromia by spectroscopy should not be dismissed in the context of hyperbilirubinemia in a patient with sickle cell anemia. Xanthochromia detected by spectrophotometry offers a vital clue that further invasive diagnosis is required.
A rare case of Bordetella avium pneumonia complicated by Raoultella planticola
Authors: Lavrenko Anna , Digtiar Nataliia , Gerasymenko Nataliia , Kaidashev Igor 
Published: March 2020

AbstractBordetella avium pneumonia immunocompromised the patient with subsequent complication by a rare opportunistic Raoultella planticola infection, which became a nosocomial pathogen in the healthcare setting.
Theoretical study of the Raman optical activity spectra of with M = Co, Rh
Authors: Abella Laura , Ludowieg Herbert D. , Autschbach Jochen 
Published: March 2020

AbstractVibrational Raman optical activity (ROA) spectra were calculated under off‐resonance, near‐resonance, and at‐resonance conditions for
(A) and under off‐resonance conditions for
(B) using a new driver software for calculating the ROA intensities from complex (damped) time‐dependent linear response Kohn‐Sham theory. The off‐resonance spectra of A and B show many similarities. At an incident laser wavelength of 532 nm, used in commercial ROA spectrometers, the spectrum of A is enhanced by near‐resonance with the ligand‐field transitions of the complex. The near‐resonance spectrum exhibits many qualitative differences compared with the off‐resonance case, but it remains bi‐signate. Even under full resonance with the ligand‐field electronic transitions, the ROA spectrum of A remains bi‐signate when the electronic transitions are broadened such as to yield absorption line widths that are comparable with those in the experimental UV‐vis absorption and electronic circular dichroism spectra.
Symptom burden in patients with cancer who are experiencing unplanned hospitalization
Authors: Newcomb Richard A. , Nipp Ryan D. , Waldman Lauren P. , Greer Joseph A. , Lage Daniel E. , Hochberg Ephraim P. , Jackson Vicki A. , Fuh Charn‐Xin , Ryan David P. , Temel Jennifer S. , El‐Jawahri Areej R. 
Published: March 2020

BackgroundInpatient supportive care programs often target patients with advanced solid tumors. To the authors' knowledge, few studies to date have characterized symptom burden in hospitalized patients with potentially curable cancers. The objective of the current study was to compare symptom burden, palliative care consultation, and readmission rates in hospitalized patients by cancer type and treatment intent.MethodsThe authors conducted a single‐center study of hospitalized patients with cancer between 2014 and 2017. They assessed physical symptoms using the Edmonton Symptom Assessment System and psychological distress using the Patient Health Questionnaire‐4 and the Primary Care PTSD (Posttraumatic Stress Disorder) Screen. Multivariate linear regression models were used to assess symptom burden, logistic regression was used to assess palliative care use, and competing risk regression was used to compare 90‐day readmission risk.ResultsA total of 1549 patients were enrolled and surveyed. The majority of patients reported moderate to severe fatigue, poor well‐being, and drowsiness with no significant differences noted by cancer type and treatment intent. Compared with other groups, patients with incurable solid cancer reported higher physical symptoms (beta coefficient [B], 4.73; P < .01) and symptoms of depression (B, 0.44; P < .01) and anxiety (B, 0.39; P < .01), but no difference in posttraumatic stress disorder. Among patients in the top quartile symptom burden according to the Edmonton Symptom Assessment System, the palliative care service was consulted in 14.7%, 7.9%, 25.0%, and 49.6%, respectively, of patients with potentially curable hematologic, potentially curable solid, incurable hematologic, and incurable solid cancers (P < .001). Compared with patients with potentially curable solid cancer, patients in each group experienced a higher risk of readmission within 90 days.ConclusionsHospitalized patients with cancer experience substantial physical and psychological symptoms. Palliative care rarely is consulted for highly symptomatic patients with potentially curable cancers. Supportive care interventions should target the needs of symptomatic patients regardless of treatment intent.
How do the size and independence of the board of trustees affect the financial and sustainable performance of socially responsible mutual funds?
Authors: Muñoz Fernando 
Published: March 2020

AbstractIn this article, I study for first time how the board of trustees’ size and independence influence the financial performance and sustainability scores of socially responsible (SR) mutual funds. The sample analyzed consists of 99 SR US domestic equity mutual funds existing in the period 2012–2018. The results obtained indicate that funds monitored by boards with a lower number of trustees and an independent chair show lower net expense ratios and better sustainability scores. In addition, smaller boards and a greater percentage of independent trustees are positively associated with the achievement of a better risk‐adjusted financial performance. Regarding SR strategies, negative screens are more likely among funds with larger and less independent boards whereas positive screens are more frequent when boards show the opposite characteristics. Another finding indicates that SR funds that implement positive screens present more industry concentrated portfolios that lead to the achievement of a more sustainable performance.
Effect of environmental corporate social responsibility on green attitude and norm activation process for sustainable consumption: Airline versus restaurant
Authors: Han Heesup , Chua Bee‐Lia , Ariza‐Montes Antonio , Untaru Elena‐Nicoleta 
Published: March 2020

AbstractThe major aim of this research was to develop theoretical frameworks clearly explicating airline and restaurant customers' decision formation for eco‐friendly products. Using a quantitative approach, we successfully broadened the norm activation theory by integrating environmental corporate social responsibility (CSR) and attitude toward the behavior. In addition, the theory was effectively deepened by taking the influence of product type (airline vs. restaurant) into account. The developed conceptual frameworks satisfactorily explained the variance in eco‐friendly purchase intention for airline products and for restaurant products, respectively. The mediating effect of attitude, ascribed responsibility, and personal moral norm was uncovered. Additionally, a salient contribution of attitude toward eco‐friendly product use in inducing intention for both airline and restaurant groups was found.
Spatial and temporal structure of diversity and demographic dynamics along a successional gradient of tropical forests in southern Brazil
Authors: Dalmaso Cilmar Antônio , Marques Marcia C. M. , Higuchi Pedro , Zwiener Victor P. , Marques Renato 
Published: March 2020

Abstract

Analysis of the structure, diversity, and demographic dynamics of tree assemblages in tropical forests is especially important in order to evaluate local and regional successional trajectories.

We conducted a long‐term study to investigate how the structure, species richness, and diversity of secondary tropical forests change over time. Trees (DBH ≥ 5 cm) in the Atlantic Forest of southern Brazil were sampled twice during a 10‐year period (2007 and 2017) in six stands (1 ha each) that varied in age from their last disturbance (25, 60, 75, 90, and more than 100 years). We compared forest structure (abundance and basal area), species richness, alpha diversity, demographic rates (mortality, recruitment, and loss or gain in basal area), species composition, spatial beta diversity, and temporal beta diversity (based on turnover and nestedness indices) among stand ages and study years.

Demographic rates recorded in a 10‐year interval indicate a rapid and dynamic process of species substitution and structural changes. Structural recovery occurred faster than beta diversity and species composition recovery. The successional gradient showed a pattern of species trade‐off over time, with less spatial dissimilarity and faster demographic rates in younger stands. As stands grow older, they show larger spatial turnover of species than younger stands, making them more stochastic in relation to species composition. Stands appear to split chronologically to some extent, but not across a straightforward linear axis, reflecting stochastic changes, providing evidence for the formation of a nonequilibrium community.

Policy implications. These results reiterate the complexity and variability in forest succession and serve as a reference for the evaluation and monitoring of local management and conservation actions and for defining regional strategies that consider the diversity of local successional trajectories to evaluate the effectiveness of restoration measures in secondary forests of the Atlantic Forest biome.
Responses of streambed bacterial groups to cycles of low‐flow and erosive floods in a small peri‐urban stream
Authors: Navratil O. , Boukerb M.A. , Perret F. , Breil P. , Caurel C. , Schmitt L. , Lejot J. , Petit S. , Marjolet L. , Cournoyer B. 
Published: March 2020

AbstractFaecal indicator bacteria (FIB) and bacterial pathogens from combined sewer overflow (CSO) in peri‐urban streams represent a major public health concern worldwide. In this study, the relationships between the hydrological regime and the loads and persistence of CSO‐borne bacterial contaminants among benthic sediments of a small peri‐urban stream were explored. Combined sewer overflow events and their impact on benthic sediment layers at a short distance from a CSO were monitored. Concentrations of Escherichia coli (EC) and intestinal enterococci (IE) and of two bacterial pathogens, Pseudomonas aeruginosa (PA) and Aeromonas caviae (AC), were assessed. Relations with hydraulic, hydromorphic and physicochemical factors were analysed. PA cells in benthic sediments increased exponentially with time (0.15 log PA per day), as long as the river discharge remained below the sediment transport. Cycles of erosive floods and low‐flow periods were found to play a critical role in PA settling and growth among benthic riverbed sediments. These hydrological and hydraulic shear forces did not correlate with changing IE, EC, and AC concentrations in the benthic sediments. Their dynamics were rather related to changing physicochemical conditions (total N, phosphate, and organic carbon). AC population size decreases most rapidly with a mean rate of 0.04 log per day according to the duration of the low‐flow period, indicating a poor tropism of AC for river systems. River sediments were found significant biotopes for PA outdoor development. These analyses demonstrate the significance of PA and AC as long‐ and short‐term indicators, respectively, of a river microbiological quality.
Enzymatic and Mechanical Extraction of Virgin Coconut Oil
Authors: Soo Pooi‐Pooi , Ali Yassoralipour , Lai Oi‐Ming , Kuan Chee‐Hao , Tang Teck‐Kim , Lee Yee‐Ying , Phuah Eng‐Tong 
Published: March 2020

AbstractThe effect of different processing methods namely enzymatic method using crude protease extract (CPE) from overripe pineapple, microwave‐assisted extraction (MAE) and ultrasound‐assisted extraction (UAE) methods on the recovery yield of virgin coconut oil (VCO) is evaluated. The physicochemical properties of VCOs namely color, iodine value (IV), refractive index, saponification value, moisture content, free fatty acid, p‐anisidine value, lipid peroxidation, fatty acid composition, triacylglycerol (TAG) composition, melting and crystallization profile are compared. The total phenolic compounds and scavenging activity of the extracted VCOs are also examined. Results reveal that enzymatic approach exhibits the highest VCO yield (77.7% ± 0.38) at 50 °C for 2 h, followed by MAE (58.6%±0.07), control without enzyme (24.1%±0.19) and UAE (24.1%±0.12). The physicochemical properties of the VCOs extracted are found to conform to APCC standards established except IV. The antioxidant activity of VCO extracted with CPE shows no significant difference with MAE and UAE methods (p > 0.05). Lauric acid appears to be the most abundant fatty acid detected in all VCO samples. Similar exotherms and endotherms are observed in both melting and crystallization profiles with two distinct peaks exhibited. The TAG compositions of the extracted VCOs are mainly LaLaLa, LaLaM, CLaLa, CCLa, and LaMM (C = Capric acid; La = Lauric acid; M = Myristic acid).Practical Applications: The results obtained from this study indicate that VCO extraction using CPE from overripe pineapple is feasible. The enzymatic extraction protocol presented here would be useful for VCO production at industrial scale with a promising oil yield.
Preparation of activated petroleum coke for supercapacitor application
Authors: Priyadharshini Ravichandran , Saravanathamizhan Ramanujam , Manimozhi Veerasamy , Manokaran Janakiraman , Balasubramanian Natesan 
Published: March 2020

AbstractThe present work is to use petroleum coke as a carbon material for energy storage application. Activated petroleum coke (APC) is prepared using potassium hydroxide as an activation agent. Then the APC is doped with nitrogen and manganese‐nitrogen components to enhance the capacitance of the material. The X‐ray diffraction result shows the turbo static behavior, which is fully disordered structure. The Fourier transform infrared spectroscopy shows the functional groups present in the prepared sample. Using the cyclic voltametry, the specific capacitances are found to be 3.2, 4.8, and 6.3 F/g for APC, nitrogen‐doped activated petroleum coke (N‐APC), and manganese‐ and nitrogen‐doped activated petroleum coke (Mn/N‐APC), respectively. The specific capacitance of charge and discharge are also found to be 3.5, 5.2, and 10.3 F/g, respectively, for the above‐prepared materials. The specific capacitance of the fabricated Mn/N‐APC electrode was found to be 76.1 F/g. From the experimental results, the energy density and power density was found to be 105 and 131.2 Wh/kg, respectively, for the abovementioned material. It is concluded from the present experiment that Mn/N‐APC shows good electrochemical properties. Hence, this can be used as a supercapacitor for energy storage applications.
A database of Holocene temperature records for north‐eastern North America and the north‐western Atlantic
Authors: van Bellen Simon , de Vernal Anne , To Anna , Ouellet‐Bernier Marie‐Michèle , Roy Natasha ,   ClimHuNor Members
Published: March 2020

AbstractCentennial‐to‐millennial temperature records of the past provide a context for the interpretation of current and future changes in climate. Quaternary climates have been relatively well studied in north‐east North America and the adjacent Atlantic Ocean over the last decades, and new research methods have been developed to improve reconstructions. We present newly inferred reconstructions of sea surface temperature for the north‐western Atlantic region, together with a compilation of published temperature records. The database thus comprises a total of 86 records from both marine and terrestrial sites, including lakes, peatlands, ice and tree rings, each covering at least part of the Holocene. For each record, we present details on seasons covered, chronologies and information on radiocarbon dates and analytical time steps. The 86 records contain a total of 154 reconstructions of temperature and temperature‐related variables. Main proxies include pollen and dinocysts, while summer was the season for which the highest number of reconstructions were available. Many records covered most of the Holocene, but many dinocyst records did not extend to the surface, due to sediment mixing, and dendroclimate records were limited to the last millennium. The database allows for the exploration of linkages between sea ice and climate and may be used in conjunction with other palaeoclimate and palaeoenvironmental records, such as wildfire records and peatland dynamics. This inventory may also aid the identification of gaps in the geographic distribution of past temperature records thus guiding future research efforts.
Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills
Authors: Yu Xi , Zuk Jennifer , Perdue Meaghan V. , Ozernov‐Palchik Ola , Raney Talia , Beach Sara D. , Norton Elizabeth S. , Ou Yangming , Gabrieli John D. E. , Gaab Nadine 
Published: March 2020

AbstractDevelopmental dyslexia affects 40–60% of children with a familial risk (FHD+) compared to a general prevalence of 5–10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlying neural characteristics of favorable reading outcomes in at‐risk children remain unknown. Utilizing a retrospective, longitudinal approach, this study examined whether putative protective neural mechanisms can be observed in FHD+Typical at the prereading stage. Functional and structural brain characteristics were examined in 47 FHD+ prereaders who subsequently developed typical (n= 35) or impaired (n= 12) reading abilities and 34 controls (FHD−Typical). Searchlight‐based multivariate pattern analyses identified distinct activation patterns during phonological processing between FHD+Typical and FHD−Typical in right inferior frontal gyrus (RIFG) and left temporo‐parietal cortex (LTPC) regions. Follow‐up analyses on group‐specific classification patterns demonstrated LTPC hypoactivation in FHD+Typical compared to FHD−Typical, suggesting this neural characteristic as an FHD+ phenotype. In contrast, RIFG showed hyperactivation in FHD+Typical than FHD−Typical, and its activation pattern was positively correlated with subsequent reading abilities in FHD+ but not controls (FHD−Typical). RIFG hyperactivation in FHD+Typical was further associated with increased interhemispheric functional and structural connectivity. These results suggest that some protective neural mechanisms are already established in FHD+Typical prereaders supporting their typical reading development.
Intestinal Microbiome‐Macrophage Crosstalk Contributes to Cholestatic Liver Disease by Promoting Intestinal Permeability in Mice
Authors: Isaacs‐Ten Anna , Echeandia Marta , Moreno‐Gonzalez Mar , Brion Arlaine , Goldson Andrew , Philo Mark , Patterson Angela M. , Parker Aimee , Galduroz Mikel , Baker David , Rushbrook Simon M. , Hildebrand Falk , Beraza Naiara 
Published: March 2020

Background and Aims
Mounting evidence supports an association between cholestatic liver disease and changes in the composition of the microbiome. Still, the role of the microbiome in the pathogenesis of this condition remains largely undefined.

Approach and Results
To address this, we have used two experimental models, administering alpha‐naphtylisocyanate or feeding a 0.1% 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine diet, to induce cholestatic liver disease in germ‐free mice and germ‐free mice conventionalized with the microbiome from wild‐type, specific pathogen‐free animals. Next, we have inhibited macrophage activation by depleting these cells using clodronate liposomes and inhibiting the inflammasome with a specific inhibitor of NOD‐, LRR‐, and pyrin domain‐containing protein 3. Our results demonstrate that cholestasis, the accumulation of bile acids in the liver, fails to promote liver injury in the absence of the microbiome in vivo. Additional in vitro studies supported that endotoxin sensitizes hepatocytes to bile‐acid–induced cell death. We also demonstrate that during cholestasis, macrophages contribute to promoting intestinal permeability and to altered microbiome composition through activation of the inflammasome, overall leading to increased endotoxin flux into the cholestatic liver.

Conclusions
We demonstrate that the intestinal microbiome contributes to cholestasis‐mediated cell death and inflammation through mechanisms involving activation of the inflammasome in macrophages.