bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary endometrioid carcinoma of the uterosacral ligament arising from deep infiltrating endometriosis after 6 years bilateral salpingo-oophorectomy due to atypical proliferative endometrioid tumor of the ovary: a rare case report
Authors: Ota Yoshiaki , Ota Kuniaki , Takahashi Toshifumi , Suzuki Soichiro , Sanoa Rikiya , Ota Ikuko , Moriya Takuya , Shiota Mitsuru 
Published: October 2020

Abstract
Background: Endometriosis can potentially lead to the development of a malignant tumor. Most malignant tumors arising from the endometriosis originate from the ovarian endometrioma, whereas those arising from extragonadal lesions are rare. We report a rare case of endometrioid carcinoma that developed from deep infiltrating endometriosis in the uterosacral ligament 6 years after treatment for atypical proliferative endometrioid tumor of the ovary in a 48-year-old woman.Case presentation: Six years ago, the patient underwent laparoscopic bilateral salpingo-oophorectomy for her right ovarian tumor with atypical proliferative (borderline) endometrioid tumor accompanied by ovarian endometrioma. The solid tumor in the cul-de-sac was detected during follow-up using magnetic resonance imaging. Positron emission tomography/computed tomography revealed an abnormal accumulation of 18F-fluorodeoxyglucose at the tumor site. Thus, tumor recurrence with borderline malignancy was suspected. The patient underwent diagnostic laparoscopy followed by hysterectomy and partial omentectomy. Retroperitoneal pelvic lymphadenectomy and para-aortic lymphadenectomy were also performed. The cul-de-sac tumor at the left uterosacral ligament was microscopically diagnosed as invasive endometrioid carcinoma arising from deep infiltrating endometriosis. The final diagnosis was primary stage IIB peritoneal carcinoma. The patient received six courses of monthly paclitaxel and carboplatin as adjuvant chemotherapy. The patient showed no evidence of recurrence for 2 years after the treatments.Conclusion: This study reports a rare case of metachronous endometriosis-related malignancy that developed 6 years after treatment for borderline ovarian tumor. If endometriosis lesions remain after bilateral salpingo-oophorectomy, the physician should keep the malignant nature of endometriosis in mind.
Construction and Prognostic Analysis of miRNA-mRNA Regulatory Network in Liver Metastasis from Colorectal Cancer
Authors: Cai Ruyun , Lu Qian , Wang Da 
Published: October 2020

Abstract
Background: Colorectal cancer (CRC) is one of the most common cancers in the world, and liver metastasis is the leading cause of colorectal cancer-related deaths. However, the mechanism of liver metastasis in CRC hasn’t been clearly elucidated.Methods: Three datasets from the Gene Expression Omnibus (GEO) database were analyzed to obtain differentially expressed genes (DEGs), which were subjected to functional enrichment analysis and protein-protein interaction analysis. Subsequently, mRNA-miRNA network was constructed and the associated DEGs and DEMs were performed for prognostic analysis. Finally, we did infiltration analysis of GAS1-associated immune cells. Results: We obtained 325 DEGs and 9 differentially expressed miRNAs (DEMs) between primary CRC and liver metastases. Enrichment analysis and protein-protein interactions (PPI) further revealed the involvement of DEGs in the formation of the inflammatory microenvironment and epithelial-mesenchymal transition (EMT) during the liver metastases process in CRC. Survival analysis demonstrated that low-expressed GAS1 as well as low-expressed hsa-miR-33b-5p was a favorable prognostic indicator of overall survival. Further exploration of GAS1 revealed that its expression was interrelated with the infiltration of immune cells in tumor tissues. Conclusions: In summary, DEGs, DEMs and their interactions found in liver metastasis of CRC may provide a basis for further understanding of the mechanism of CRC metastasis.
WITHDRAWN: Mental Health and Well-being of Empty-nesters: A Chinese Urban Case Study
Authors: HuiYang  , Hagedorn Aaron , Chen Honglin , Zhang Ronghua 
Published: October 2020

Abstract
The research examined the mental health and well-being of a sample of empty-nesters in Jinan City, Shandong Province. An in-depth individual interview approach, with document analysis and participant observation was performed on three types of interviewees (N = 33) recruited via purposive sampling. The empty-nesters faced many unique problems, especially a sense of being disjointed from the family, community and society. Influencing factors included Chinese traditional filial piety culture, lagging implementation of relevant policies and development of community ageing services, as well as the loss of productive roles for the empty nesters. Implications for social work services are identified.
Acute Myocardial Infarction During Hospitalization for Community-Acquired Pneumonia in Geriatric Patients: A Cross-Sectional Study
Authors: Kang Yu , Fang Xiang-Yang , Wang Dong , Wang Xiao-Juan 
Published: October 2020

Abstract
Background: Community-acquired pneumonia (CAP) and acute myocardial infarction cardiovascular (AMI) are two important health issues in elderly. Little is known regarding characteristics of AMI in elderly hospitalized for CAP. Therefore, we investigated the prevalence, characteristics compared with younger patients, impact on clinical outcomes and risk factors of AMI during hospitalization for CAP in geriatric patients.Methods: 11009 adult inpatients consisted of 5111 elderly patients≥ 65 years and 5898 patients＜65 years in respiratory ward and 1095 inpatients ≥65 years in geriatrics ward diagnosed with CAP were retrospectively analyzed by electronic medical records. Results: 159 (3.1%) elderly patients in respiratory ward and 77 (7.0%) patients in geriatrics ward experienced AMI during hospitalization for CAP. AMI were more frequently seen in elderly patients (3.1% vs. 1.0 %), Patients≥65 years who experienced AMI during hospitalization for CAP had higher percentage of respiratory failure (P = 0.001), hypertension (P = 0.008), dyspnea (P=0.046), blood urea nitrogen (BUN)≥7mmol/L (P < 0.001), serum sodium <130 mmol/L(P = 0.005) and had higher in-hospital mortality compared to patients＜65 years (10.1% vs. 6.6%). AMI was associated with increased in-hospital mortality (odds ratio, OR, with 95% confidence interval: 1.49 [1.24-1.82]; P<0.01). Respiratory failure (OR, 1.34 [1.15–1.54]; P<0.01), preexisting coronary artery disease (OR, 1.31[1.07–1.59]; P = 0.02), diabetes (OR, 1.26 [1.11–1.42]; P = 0.02), BUN (OR, 1.23 [1.01–1.49]; P = 0.04), and impaired consciousness (OR, 1.19 [1.07–1.32]; P = 0.03) were correlated with the occurrence of AMI in the elderly.Conclusions: The incidence of AMI during CAP hospitalization in geriatric patients is notable and have an impact on in-hospital mortality. Characteristics of the elderly differ from the general population. Particular attention should be paid to elderly patients with risk factors for AMI. Our study may represent useful information for clinical strategies aimed at preventing AMI and decreasing mortality in geriatric patients hospitalization for CAP.
The Use of Medicinal Plant to Prevent COVID-19 in Nepal
Authors: Khadka Dipak , Dhamala Man Kumar , Li Feifei , Aryal Prakash Chandra , Magar Pappu Rana , Bhatta Sijar , Thakur Manju Shree , Basnet Anup , Shi Shi , Cui Dafang 
Published: October 2020

Abstract
Background: Medicinal plants are the fundamental unit of traditional medicine system in Nepal. Nepalese people are rich in traditional medicine especially in folk medicine (ethnomedicine) and this system is gaining much attention after 1995. The use of medicinal plants have increased during COVID-19 pandemic as a private behavior (not under the control of government). Lot of misinterpretations of the use of medicinal plants to treat or prevent COVID-19 have been spreading throughout Nepal which need to be managed proactively. In this context, a research was needed to document medicinal plants used, their priority of use in society, cultivation status and source of information people follow to use them. This study aimed to document the present status of medicinal plant use and make important suggestion to the concern authorities.Methods: This study used a web-based survey to collect primary data related to medicinal plants used during COVID-19. A total of 774 respondents took part in the survey. The study calculated the relative frequencies of citation (RFC) for the recorded medicinal plants. The relationship between plants recorded and different covariates (age, gender education, occupation, living place, and treatment methods were assessed using Kruskal Wallis test and Wilcox test. The relationship between the information sources people follow and respondent characteristics, were assessed using chi-square test.Results:The study found that the use of medicinal plants has increased during COVID-19 and most of the respondents recommended medicinal plants to prevent COVID-19. This study recorded a total of 63 plants belonging to 42 families. The leaves of the plants were the most frequently used. The Zingiber officinale was the most cited species with the frequency of citation 0.398. Most of the people (45.61%), were getting medicinal plants from their home garden. The medicinal plants recorded were significantly associated with the education level, location of home, primary treatment mode, gender, and age class. The information source of plants was significantly associated with the education, gender, method of treatment, occupation, living with family, and location of home during lockdown caused by COVID-19.Conclusions:People were using more medicinal plants during COVID-19 claiming that they can prevent or cure COVID-19. This should be taken seriously by concerned authorities. The authorities should test the validity of these medicinal plants and control the flow of false information spread through research and awareness programs.
D-MT Prompts the Anti-Tumor Effect of Oxaliplatin by Inhibiting IDO Expression in a Mouse Model of Colon Cancer
Authors: Zhao Tiesuo , Zhang Yongxi , Fan Wenyan , Guo Jing , Ren Weiwei , Li Ruipeng , Zhu Gaozan , Li Jie , Li Minjie , Li Xinyi , Wang Shenggen , Dang Chengxue , Jia Huijie 
Published: October 2020

Abstract
BackgroundColon cancer is one of the most common malignant tumors in the digestive system. Although oxaliplatin, a chemotherapy drug, has been clinically used to treat colon cancer, its therapeutic effect is unsatisfactory. MethodsIn the present work, it has been proved that indoleamine dioxygenase 2,3 (IDO), an immune checkpoint, is a result of tolerance to chemotherapy. Herein, the anti-tumor effect of treatment with oxaliplatin and D-MT, an IDO inhibitor, on the mice was observed by recording the tumor growth and survival of the mice, and detecting T cell infiltration in tumor tissues and the ratios of immune cells in the spleen by corresponding methods. ResultsWe found that the combination of oxaliplatin and D-MT significantly inhibited tumor growth, prolonged the survival of tumor-bearing mice, increased the cell apoptosis. More importantly, the combination treatment increased the ratios of CD4+ T, CD8+ T and NK cells from the spleen in tumor-bearing mice, and prompted T cell infiltration in tumor tissues. ConclusionThis study provided a new therapeutic strategy for colon cancer treatment in the clinic, especially for patients with oxaliplatin resistance.
How Does Dementia Begin to Manifest in Bipolar Disorder? A Description of Prodromal Clinical and Cognitive Changes.
Authors: Callahan Brandy L. , McLaren-Gradinaru Michael , Burles Ford , Iaria Giuseppe 
Published: October 2020

Abstract
BackgroundThis study aims to identify longitudinal cognitive changes that may signal early dementia in bipolar disorder.MethodsParticipants were 114 adults with bipolar disorder, all initially non-demented, who underwent annual neuropsychological assessment up to ten years (47.3 months average follow-up). A small subset (n=12) also had available structural neuroimaging data. Longitudinal features associated with future dementia status were examined with linear mixed-effects models, and yearly differences between incident dementia and controls cases were examined in the six years prior to diagnosis.ResultsTwenty-six participants (22.8%) developed dementia over the follow-up period (‘incident cases’), and the remaining 88 (77.2%) remained dementia-free (‘controls’). Alzheimer’s disease was the most common presumed etiology in the incident cases, and this aligned with findings of smaller hippocampal volumes relative to controls. The incident cases showed clearly declining trajectories in episodic memory, verbal fluency and attention. Story recall and digit symbol substitution showed the earliest decline, four and five years before diagnosis respectively. Digit symbol substitution was most accurate at distinguishing cases from controls: impaired performance (<-1.5 SD) at any time during the follow-up period was associated with 54% sensitivity and 87% specificity of future dementia.ConclusionsProdromal dementia in bipolar disorder can be detected up to five years before onset using the same cognitive tests used in psychiatrically-healthy older adults. Cognition in the natural course of bipolar disorder is generally stable, and impairment or marked decline on measures of memory, fluency or attention may indicate an early neurodegenerative process.
Study on the macro and micro grouting process and the influence mechanism of cracks in soft coal seam
Authors: Yu Hui , Jia Housheng , Liu Shaowei , Liu Zhihe , Li Baoyu 
Published: October 2020

Abstract
Grouting is an important method to reinforce soft coal roadway, and the presence of primary cracks in the coal body has an important influence on the grouting effect. Using the PFC (Particle Flow Code) method, the grouting process of the soft coal seam was simulated. The mechanism of primary cracks on grouting was revealed, while the influence of fracture characteristics and grouting pressure on the grouting effect was analyzed. The results demonstrated that grouting in the soft coal seam involved the stages of seepage, rapid splitting, slow splitting, and stability. Due to the presence of primary cracks, the grouting diffusion radius increased significantly. Under the slurry pressure, the tensile stress concentration was formed at the crack tip, and the slurry split the coal once the splitting pressure was reached. In addition, the distribution characteristics of fractures were found to have a great influence on the grouting effect. It was observed that smaller fracture spacing was associated with a larger slurry diffusion radius and thus easier penetration of the primary crack tips. The fracture angle affected the direction of fracture propagation. The secondary fracture formed by splitting was a tensile fracture, which was more likely to extend along the direction parallel to the maximum principal stress. Overall, these simulation results have guiding significance for the setting of reasonable spacing of grouting holes in the practice of grouting engineering.
Shear damage stress and frequency spectral characteristics of dry and saturated red sandstone determined by acoustic emission
Authors: Wang Yunfei , Liu Xiao , Li Zhen 
Published: October 2020

Abstract
Dry and saturated red sandstone direct shear tests under different normal stresses were carried out in the rock shear test system to clarify the shear strength and damage characteristics. The cumulative ring count, cumulative energy, dominant frequency, secondary dominant frequency, and the effects of water saturation and normal stress on them were analyzed in detail. Results show that the cumulative ring count and cumulative energy curves of acoustic emission (AE) can be divided into linear increasing and step jump stages. The cumulative curves in the dry state have significant steps, thereby indicating that the repetitive process of “crack rapid development — energy accumulation” is significant. The cumulative ring count and cumulative energy are great when the normal stress is high. Under the same normal stress, the cumulative ring count and cumulative energy in the dry state are greater than those in the saturated state. The shear damage stresses were determined according to the cumulative curves. The failure process of red sandstone is divided into crack initiation and crack rapid development zones. The variation law of shear damage stress and shear strength of red sandstone is basically consistent. The growth rate of shear damage stress and strength of dry red sandstone is greater than that of saturated red sandstone with the increase in normal stress. The dominant and secondary dominant frequencies of dry and saturated red sandstone decrease with the increase in normal stress. The dominant frequency is less than the secondary frequency. Under the same normal stress, the dominant and secondary dominant frequencies of red sandstone shear failure in the dry state are less than those in the saturated state, thereby indicating that the shear microcrack scale of red sandstone in the saturated state is smaller than that in the dry state. The results have a certain theoretical significance to determine the shear damage degree of red sandstone by AE monitoring.
Hybrid-COVID: A novel hybrid 2D/3D CNN based on cross-domain adaptation approach for COVID-19 screening from chest X-ray images
Authors: Bayoudh Khaled , Hamdaoui Fayçal , Mtibaa Abdellatif 
Published: October 2020

Abstract
So far, COVID-19, the novel coronavirus, continues to spread rapidly in most countries of the world, putting people's lives at risk. According to the WHO, respiratory infections occur primarily in the majority of patients treated with COVID-19. For decades, chest X-ray (CXR) technologies have proven their ability to accurately detect and treat respiratory diseases. Deep learning techniques, as well as the availability of a large number of CXR samples, have made a significant contribution to the fight against this pandemic. However, the most common screening methods are based on 2D CNNs, since 3D counterparts are enormously costly and labor-intensive. In this study, a hybrid 2D/3D convolutional neural network (CNN) architecture for COVID-19 screening using CXRs has been developed. The proposed architecture consists of the incorporation of a pre-trained deep model (VGG-16) and a shallow 3D CNN, combined with a depth-wise separable convolution layer and a spatial pyramid pooling module (SPP). Specifically, the depth-wise separable convolution helps to preserve the useful features while reducing the computational burden of the model. The SPP module is designed to extract multi-level representations from intermediate ones. Experimental results show that the proposed framework can achieve reasonable performances when evaluated on a collected dataset (3 classes: COVID-19, Pneumonia, and Normal). Notably, it achieved a sensitivity of 98.33%, a specificity of 98.68% and an overall accuracy of 96.91%
Calcium-suppressed Technique in Dual-layer Detector Computed Tomography to Evaluate Knee Articular Cartilage
Authors: Meng Qinglin , Liu Mengqi , Deng Weiwei , Chen Ke , Wang Botao , Zhang Xiaohuan , Chen Zhiye 
Published: October 2020

Background:
Calcium-suppressed (CaSupp) technique involving spectral-based images
has been used to observe bone marrow edema by removing calcium components from the image.

Objective:
This study aimed to evaluate the knee articular cartilage using the CaSupp technique in
dual-layer detector computed tomography (DLCT).

Methods:
Twenty-eight healthy participants and two patients with osteoarthritis were enrolled,
who underwent DLCT and magnetic resonance imaging (MRI) examination. CaSupp images were
reconstructed from spectral-based images using a calcium suppression algorithm and were overlaid
with conventional CT images for visual evaluation. The morphology of the knee cartilage was evaluated,
and the thickness of the articular cartilage was measured on sagittal proton density-weighted
and CaSupp images in the patellofemoral compartment.

Results:
No abnormal signal or density, cartilage defect, and subjacent bone ulceration were observed
in the lateral and medial femorotibial compartments and the patellofemoral compartment on
MRI images and CaSupp images for the 48 normal knee joints. CaSupp images could clearly identify
cartilage thinning, defect, subjacent bone marrow edema, and edema of the infrapatellar fat pad
in the same way as MRI images in the three knee joints with osteoarthritis. A significant difference
was found in the mean thickness of the patellar cartilage between MRI images and CaSupp images,
while the femoral cartilage presented no significant difference in thickness between MRI images
and CaSupp images in all 48 knee joints.

Conclusion:
The present study demonstrated that CaSupp images could effectively be used to perform
the visual and quantitative assessment of knee cartilage.
Ultrasound Diagnostic Method in Vascular Dementia: Current Concepts
Authors: Siniscalchi Antonio , Gray Cleona , Malferrari Giovanni 
Published: October 2020

Background:
Increasing interest in identifying of cerebral hemodynamics alterations as cause of possible onset
or worsening of cognitive impairment in elderly patients with vascular risk factors.

Introduction:
Intracranial ultrasound is a non-invasive, repeatable inexpensive method for recording variation of the
cerebral vascular tree in physiological and pathological conditions as well in the diagnosis of vascular dementia (VaD).

Methods:
PubMed, Embase, Cochrane library and reference lists have been searched for articles published until March
30, 2020.

Results:
Clinical studies reported different Transcranial Doppler (TCD) parameters and subsequently transcranial duplex
with color code (TCCD) in patients affected by vascular dementia. The number of studies using TCCD remains limited
and most of available data are still based on TCD. However, the use of transcranial Doppler could better stratify elderly
patients with initial signs of cognitive impairment.

Conclusion:
Intracranial ultrasound employment to detect cerebral hemodynamic changes in VaD patients has been
briefly discussed in this review.
Herbal Drug Interaction: Mechanistic Details through Pharmacokinetic Portfolio
Authors: Ahmed Salman , Khan Haroon , Mirzaei Hamed , Hasan Muhammad Mohtasheemul , Eddouks Mohamed , Daglia Maria 
Published: October 2020

Background:
A large number of individuals today use herbs as a drug alongside
medicine and non-physician recommended medications, as herbs are thought to be natural and
safe. However, there are many herbs that can potentially interact with other drugs, causing hazardous
effects and/or diminished therapeutic effects of other prescriptions.

Objective:
It is ought to be comprehended that herbal drugs contain multiple active compounds in
different percentages, which can change the enzymatic frameworks, transporters, and, additionally,
the physiological processes.

Methods:
Different search engines such as Googlescholar, Scopus, ScienceDirect, were used for the search of the data on
the subject; pharmacokinetic drug interactions with the herbal products.

Results:
This worldwide increment in herbal drug popularity has risen with respect to HDIs. These
PD or PK interactions are particularly significant for medications. Assessment of herbal drug interaction
is difficult because of inconsistency in herbal drug composition and frequently meager information
of active constituent pharmacokinetic. These restrictions are bewildered further by the differing
points of view concerning herbal product regulation.

Conclusion:
It is concluded that a basic assessment of certain pharmacokinetic HDI is needed to settle on educated choices
in regard to patient safety. The expanding comprehension of HDPKI will make more attention to the potential interactions.