bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing short-season cotton genotypes with high harvest index might be an advantageous option under late duration plantings
Authors: Iqbal Muhammad , Khan Mueen Alam , Chattha Waqas Shafqat 
Published: April 2020

AbstractShort duration cotton (Gossypium hirsutum L.) cultivar may be more profitable for the growers, as it will have shortened critical growth window for drought, heat and insect pests. Therefore, in the present research work, two cotton advance lines IUB-71 and IUB-73 along with an approved cotton cultivar IUB-13 were tested under four different sowing dates i.e. S1 (25th April), S2 (10th May), S3 (25th May) and S4 (10th June) in 2017 and 2018 under field condition. Field layout was RCBD factorial with four sowing dates as one factor and three cotton genotypes as another factor with three replications. Data were recorded for plant height, total number of nodes, bolls per plant, seed cotton yield (SCY), above ground fresh biomass (AGFB) and harvest index (HI). An overall decreasing trend with increasing sowing dates was observed in all the traits except HI that relatively increased in all the three genotypes. Within each sowing date, a higher value for each trait was observed for genotype IUB-73 except for AGFB might be due to higher reproductive allocation. It is concluded that IUB-73 due to superior SCY and HI specifically under late planting is best fit for short cotton seasons with reduced critical window for cotton management.
Integration of RF rectenna with thin film solar cell to power wearable electronics
Authors: Naresh B. , Singh Vinod Kumar , Sharma V. K. 
Published: April 2020

AbstractThis paper reports an integration of dual band microstrip antenna with thin film amorphous silicon solar cell which creates a wearable system to harvest microwave energy. The multiple layers in the encapsulation of the thin film solar cell are used as a substrate for microstrip antenna. The rectifier and matching circuit are designed on cotton jeans material and the whole system is mechanically supported by the foam of 5 mm thick. The performance of the antenna is studied for the mechanical bending condition. The device has maintained good power conversion efficiency. The efficiency of the voltage doubler is tested by varying radio frequency power levels from −30 to10 dBm. The voltage doubler conversion efficiency at 1.85 and 2.45 GHz are 58 and 43%, respectively, for a load of 7.5 kΩ for an input power level of −5 dBm.
Characterization of electrolyte content in urine samples through a differential microfluidic sensor based on dumbbell-shaped defected ground structures
Authors: Muñoz-Enano J. , Vélez P. , Gil M. , Jose-Cunilleras E. , Bassols A. , Martín F. 
Published: April 2020

AbstractIn this paper, a differential microfluidic sensor and comparator based on a pair of microstrip lines loaded with dumbbell-shaped defected ground structure resonators is applied to the characterization of electrolyte concentration in samples of horse urine. Since variations in the total electrolyte content in urine may be indicative of certain pathologies, the interest is to use the device as a comparator, in order to determine changes in the electrolyte concentration as compared to a reference level. To validate the approach, we have made differential measurements of a set of urine samples with different electrolyte concentrations (which have been previously obtained by means of electrochemical methods). The obtained results correlate with the nominal electrolyte concentrations of the samples, thereby pointing out the potential of the approach as a low-cost pre-screening method (or complementary diagnosis system) to detect potential pathologies or diseases in horses and other animals.
Repercussions of maternal exposure to high-fat diet on offspring feeding behavior and body composition: a systematic review
Authors: Chaves Wenicios Ferreira , Pinheiro Isabeli Lins , da Silva Jacqueline Maria , Manhães-de-Castro Raul , da Silva Aragão Raquel 
Published: April 2020

AbstractMaternal nutrition is an environmental determinant for offspring growth and development, especially in critical periods. Nutritional imbalances during these phases can promote dysregulations in food intake and feeding preference in offspring, affecting body composition. The aim of this review is to summarize and discuss the effects of maternal high-fat diet (HFD) on offspring feeding behavior and body composition. A search was performed in the PUBMED, SCOPUS, Web of Science, and LILACS databases. Inclusion criteria were studies in rodents whose mothers were submitted to HFD that assessed outcomes of food or caloric intake on offspring and food preference associated or not with body weight or body composition analysis. At the end of the search, 17 articles with the proposed characteristics were included. In these studies, 15 articles manipulated diet during pregnancy and lactation, 1 during pregnancy only, and 1 during lactation only. Maternal exposure to a HFD leads to increased food intake, increased preference for HFDs, and earlier food independence in offspring. The offspring from HFD mothers present low birthweight but become heavier into adulthood. In addition, these animals also exhibited greater fat deposition on white adipose tissue pads. In conclusion, maternal exposure to HFD may compromise parameters in feeding behavior and body composition of offspring, impairing the health from conception until adulthood.
Wandering Money: Valuating and Mediating Post-War Remittances in Vietnam
Authors: Small Ivan V. 
Published: April 2020

AbstractRemittances from the Vietnamese diaspora have played an important role in Vietnam's post-Cold War economic development, providing important inputs to a range of household spending areas, from education to health care. In the case of Vietnam, however, remittances are also caught up with memories and traumas of war, betrayal, separation, and exodus. This article traces that history and illustrates how Vietnam's particular post-war refugee and remittance situations and channels illuminate networks and exacerbate inherent contradictions and comparisons in the mobile flows of finance, people, and goods across borders. Examining genealogies of remittance reception and management offers insight and intervention into analytical assumptions of the distancing and mediating functions inherent to classic conceptions of money, as well as the reciprocity and recognition perceptions mapped onto gift economies.
Influence of Elastic Scattering on Electron Swarm Distribution in Electrified Gases
Authors: Schmalzried A. , Luque A. 
Published: April 2020

AbstractThe propagation of energetic electrons through air is one key component in the generation of high‐energy atmospheric phenomena such as lightning‐generated X‐ray bursts, terrestrial gamma ray flashes (TGFs), and gamma ray glows. We show here that models for this propagation can be considerably affected by the parameterization of the differential cross section of elastic scattering of electrons on the molecular components of air. We assess existing parameterizations and propose a more accurate one that builds upon the most up‐to‐date measurements. Then we conclude that by overweighting the forward scattering probability, previous works may have overestimated the production of runaway electrons under high electric fields close to the thermal runaway threshold.
CSO Reduction by Integrated Model Predictive Control of Stormwater Inflows: A Simulated Proof of Concept Using Linear Surrogate Models
Authors: Lund N. S. V. , Borup M. , Madsen H. , Mark O. , Mikkelsen P. S. 
Published: April 2020

AbstractCombined sewer overflows (CSO) of mixed stormwater and wastewater pollute nearby receiving surface waters and pose a risk to the environment and human health. We use “integrated stormwater inflow control” to mitigate CSO by dynamically controlling the inflow of stormwater to the combined sewer system in real time, expanding the physical space of traditional real‐time control. This control is carried out with model predictive control (MPC), which we base on convex optimization including a linear internal surrogate model of the controllable aboveground and belowground infrastructure. A detailed hydrodynamic model is used to evaluate the results and recursively initialize the surrogate model. MPC dynamically decides when to let stormwater enter the sewer system and when to store and convey excess stormwater in the aboveground infrastructure otherwise intended for passive cloudburst management. The performance was quantified in a simulation study in Copenhagen, Denmark, using a 1‐D distributed hydrodynamic model and 32 rain events from 2016, of which 18 caused CSO in the situation without control. Four of the 18 CSO events were avoided with MPC, and the total CSO volume was reduced by 98.4% of the potential reducible volume. For one event, stormwater was unnecessarily kept on the surface because the surrogate model wrongly predicted a CSO. The computational cost was in all cases compatible with an operational implementation. With the invention of proper actuators for control of stormwater inflows, we show that MPC of stormwater inflows may be a viable supplement to more traditional passive ways of managing stormwater in urban areas.
Use and abuse of dietary supplements in persons with diabetes
Authors: Hannon Bridget A. , Fairfield William D. , Adams Bryan , Kyle Theodore , Crow Mason , Thomas Diana M. 
Published: April 2020

AbstractThe dietary supplement industry has estimated sales of over $30 billion in the US and over $100 billion globally. Many consumers believe that dietary supplements are safer and possibly more effective than drugs to treat diabetes. The sheer volume of the literature in this space makes compiling them into one review challenging, so much so that primarily narrative reviews currently exist. By applying the interactive database supplied by the Office of Dietary Supplements at the National Institutes of Health, we identified the top 100 ingredients that appeared most often in dietary supplement products. One-hundred different keyword searches using the ingredient name and the word diabetes were performed using a program developed to automatically scrape PubMed. Each search was retained in a separate Excel spreadsheet, which was then reviewed for inclusion or exclusion. The studies that met the inclusion criteria were evaluated for effect of reducing and controlling diabetes. The PubMed scrape resulted in 6217 studies. For each keyword search only the most recent 100 were retained, which refined the total to 1823 studies. Of these 425 met the screening criteria. The ingredients, fiber, selenium and zinc had the most studies associated with improvement in diabetes. Several popular supplement ingredients (phosphorus, pantothenic acid, calcium, magnesium, glutamine, isoleucine, tyrosine, choline, and creatine monohydrate) did not result in any studies meeting our screening criteria. Our study demonstrates how to automate reviews to filter and collapse literature in content areas that have an enormous volume of studies. The aggregated set of studies suggest there is little clinical evidence for the use of dietary supplements to reduce or control diabetes.
Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank
Authors: Alloza C. , Blesa-Cábez M. , Bastin M. E. , Madole J. W. , Buchanan C. R. , Janssen J. , Gibson J. , Deary I. J. , Tucker-Drob E. M. , Whalley H. C. , Arango C. , McIntosh A. M. , Cox S. R. , Lawrie S. M. 
Published: April 2020

AbstractSchizophrenia is a highly heritable disorder with considerable phenotypic heterogeneity. Hallmark psychotic symptoms can be considered as existing on a continuum from non-clinical to clinical populations. Assessing genetic risk and psychotic-like experiences (PLEs) in non-clinical populations and their associated neurobiological underpinnings can offer valuable insights into symptom-associated brain mechanisms without the potential confounds of the effects of schizophrenia and its treatment. We leveraged a large population-based cohort (UKBiobank,N = 3875) including information on PLEs (obtained from the Mental Health Questionnaire (MHQ); UKBiobank Category: 144;Nauditory hallucinations = 55,Nvisual hallucinations = 79,Npersecutory delusions = 16,Ndelusions of reference = 13), polygenic risk scores for schizophrenia (PRSSZ) and multi-modal brain imaging in combination with network neuroscience. Morphometric (cortical thickness, volume) and water diffusion (fractional anisotropy) properties of the regions and pathways belonging to the salience, default-mode, and central-executive networks were computed. We hypothesized that these anatomical concomitants of functional dysconnectivity would be negatively associated with PRSSZand PLEs. PRSSZwas significantly associated with a latent measure of cortical thickness across the salience network (r = −0.069,p = 0.010) and PLEs showed a number of significant associations, both negative and positive, with properties of the salience and default mode networks (involving the insular cortex, supramarginal gyrus, and pars orbitalis,pFDR < 0.050); with the cortical thickness of the insula largely mediating the relationship between PRSSZand auditory hallucinations. Generally, these results are consistent with the hypothesis that higher genetic liability for schizophrenia is related to subtle disruptions in brain structure and may predispose to PLEs even among healthy participants. In addition, our study suggests that networks engaged during auditory hallucinations show structural associations with PLEs in the general population.
DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies
Authors: Oostindie Simone C. , van der Horst Hilma J. , Kil Laurens P. , Strumane Kristin , Overdijk Marije B. , van den Brink Edward N. , van den Brakel Jeroen H. N. , Rademaker Hendrik J. , van Kessel Berris , van den Noort Juliette , Chamuleau Martine E. D. , Mutis Tuna , Lindorfer Margaret A. , Taylor Ronald P. , Schuurman Janine , Parren Paul W. H. I. , Beurskens Frank J. , Breij Esther C. W. 
Published: April 2020

AbstractTetraspanin CD37 has recently received renewed interest as a therapeutic target for B-cell malignancies. Although complement-dependent cytotoxicity (CDC) is a powerful Fc-mediated effector function for killing hematological cancer cells, CD37-specific antibodies are generally poor inducers of CDC. To enhance CDC, the E430G mutation was introduced into humanized CD37 monoclonal IgG1 antibodies to drive more efficient IgG hexamer formation through intermolecular Fc-Fc interactions after cell surface antigen binding. DuoHexaBody-CD37, a bispecific CD37 antibody with the E430G hexamerization-enhancing mutation targeting two non-overlapping epitopes on CD37 (biparatopic), demonstrated potent and superior CDC activity compared to other CD37 antibody variants evaluated, in particular ex vivo in patient-derived chronic lymphocytic leukemia cells. The superior CDC potency was attributed to enhanced IgG hexamerization mediated by the E430G mutation in combination with dual epitope targeting. The mechanism of action of DuoHexaBody-CD37 was shown to be multifaceted, as it was additionally capable of inducing efficient antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis in vitro. Finally, potent anti-tumor activity in vivo was observed in cell line- and patient-derived xenograft models from different B-cell malignancy subtypes. These encouraging preclinical results suggest that DuoHexaBody-CD37 (GEN3009) may serve as a potential therapeutic antibody for the treatment of human B-cell malignancies.
DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma
Authors: Haider Zahra , Landfors Mattias , Golovleva Irina , Erlanson Martin , Schmiegelow Kjeld , Flægstad Trond , Kanerva Jukka , Norén-Nyström Ulrika , Hultdin Magnus , Degerman Sofie 
Published: April 2020

AbstractDespite having common overlapping immunophenotypic and morphological features, T-cell lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) have distinct clinical manifestations, which may represent separate diseases. We investigated and compared the epigenetic and genetic landscape of adult and pediatric T-ALL (n = 77) and T-LBL (n = 15) patient samples by high-resolution genome-wide DNA methylation and Copy Number Variation (CNV) BeadChip arrays. DNA methylation profiling identified the presence of CpG island methylator phenotype (CIMP) subgroups within both pediatric and adult T-LBL and T-ALL. An epigenetic signature of 128 differentially methylated CpG sites was identified, that clustered T-LBL and T-ALL separately. The most significant differentially methylated gene loci included the SGCE/PEG10 shared promoter region, previously implicated in lymphoid malignancies. CNV analysis confirmed overlapping recurrent aberrations between T-ALL and T-LBL, including 9p21.3 (CDKN2A/CDKN2B) deletions. A significantly higher frequency of chromosome 13q14.2 deletions was identified in T-LBL samples (36% in T-LBL vs. 0% in T-ALL). This deletion, encompassing the RB1, MIR15A and MIR16-1 gene loci, has been reported as a recurrent deletion in B-cell malignancies. Our study reveals epigenetic and genetic markers that can distinguish between T-LBL and T-ALL, and deepen the understanding of the biology underlying the diverse disease localization.
Oxidative resistance of leukemic stem cells and oxidative damage to hematopoietic stem cells under pro-oxidative therapy
Authors: Chen Yongfeng , Liang Yong , Luo Xingjing , Hu Qiongying 
Published: April 2020

AbstractLeukemic stem cells (LSCs) and hematopoietic stem cells (HSCs) are both dependent on the hypoxic bone marrow (BM) microenvironment (also known as the BM niche). There is always fierce competition between the two types of cells, and the former exhibits a greater competitive advantage than the latter via multiple mechanisms. Under hypoxia, the dynamic balance between the generation and clearing of intracellular reactive oxygen species (ROS) is conducive to maintaining a quiescent state of cells. Quiescent LSCs can reside well in the BM niche, avoiding attack by chemotherapeutic agents, which is the cause of chemotherapeutic resistance and relapse in leukemia. HSCs acquire energy mainly through anaerobic glycolysis, whereas LSCs achieve energy metabolism largely through mitochondrial oxidative respiration. Mitochondria are the primary site of ROS generation. Thus, in theory, mitochondria-mediated respiration will cause an increase in ROS generation in LSCs and a higher intracellular oxidative stress level. The sensitivity of the cells to pro-oxidant drugs increases as well, which allows for the selective clearing of LSCs by pro-oxidative therapy. However, HSCs are also highly sensitive to changes in ROS levels, and the toxic effects of pro-oxidant drugs on HSCs poses a major challenge to pro-oxidative therapy in leukemia. Given the above facts, we reviewed studies on the oxidative resistance of LSCs and the oxidative damage to HSCs under pro-oxidative therapy. An in-depth investigation into the oxidative stress status and regulatory mechanisms of LSCs and HSCs in hypoxic environments will promote our understanding of the survival strategy employed by LSCs and the mechanism of the oxidative damage to HSCs in the BM niche, thus facilitating individualized treatment of leukemia patients and helping eliminate LSCs without disturbing normal hematopoietic cells.
CD41-deficient exosomes from non-traumatic femoral head necrosis tissues impair osteogenic differentiation and migration of mesenchymal stem cells
Authors: Zhu Weiwen , Guo MinKang , Yang Wu , Tang Min , Chen Tingmei , Gan Delu , Zhang Dian , Ding Xiaojuan , Zhao Anping , Zhao Pei , Yan Wenlong , Zhang Jian 
Published: April 2020

AbstractNon-traumatic osteonecrosis of the femoral head (ONFH) is clinically a devastating and progressive disease without an effective treatment. Mesenchymal stem cells (MSCs) transplantation has been used to treat ONFH in early stage, but the failure rate of this therapy is high due to the reduced osteogenic differentiation and migration of the transplanted MSCs related with pathological bone tissues. However, the mechanism responsible for this decrease is still unclear. Therefore, we assume that the implanted MSCs might be influenced by signals delivered from pathological bone tissue, where the exosomes might play a critical role in this delivery. This study showed that exosomes from ONFH bone tissues (ONFH-exos) were able to induce GC-induced ONFH-like damage, in vivo and impair osteogenic differentiation and migration of MSCs, in vitro. Then, we analyzed the differentially expressed proteins (DEPs) in ONFH-exos using proteomic technology and identified 842 differentially expressed proteins (DEPs). On the basis of gene ontology (GO) enrichment analysis of DEPs, fold-changes and previous report, cell adhesion-related CD41 (integrin α2b) was selected for further investigation. Our study showed that the CD41 (integrin α2b) was distinctly decreased in ONFH-exos, compared to NOR-exos, and downregulation of CD41 could impair osteogenic differentiation and migration of the MSCs, where CD41-integrin β3-FAK-Akt-Runx2 pathway was involved. Finally, our study further suggested that CD41-affluent NOR-exos could restore the glucocorticoid-induced decline of osteogenic differentiation and migration in MSCs, and prevent GC-induced ONFH-like damage in rat models. Taken together, our study results revealed that in the progress of ONFH, exosomes from the pathological bone brought about the failure of MSCs repairing the necrotic bone for lack of some critical proteins, like integrin CD41, and prompted the progression of experimentally induced ONFH-like status in the rat. CD41 could be considered as the target of early diagnosis and therapy in ONFH.
Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
Authors: Cai Yusheng , Zhou Huanhuan , Zhu Yinhua , Sun Qi , Ji Yin , Xue Anqi , Wang Yuting , Chen Wenhan , Yu Xiaojie , Wang Longteng , Chen Han , Li Cheng , Luo Tuoping , Deng Hongkui 
Published: April 2020

AbstractCellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms, contributes to tissue dysfunction, and drives age-related phenotypes. The clearance of senescent cells is expected to decrease chronic, low-grade inflammation and improve tissue repair capacity, thus attenuating the decline of physical function in aged organisms. However, selective and effective clearance of senescent cells of different cell types has proven challenging. Herein, we developed a prodrug strategy to design a new compound based on the increased activity of lysosomal β-galactosidase (β-gal), a primary characteristic of senescent cells. Our prodrug SSK1 is specifically activated by β-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types. In aged mice, our compound effectively cleared senescent cells in different tissues, decreased the senescence- and age-associated gene signatures, attenuated low-grade local and systemic inflammation, and restored physical function. Our results demonstrate that lysosomal β-gal can be effectively leveraged to selectively eliminate senescent cells, providing a novel strategy to develop anti-aging interventions.