bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating outcomes of children's asthma self‐management education through sustainable community–university partnerships
Authors: Quaranta Judith E. , Geoghegan Rosemarie , Gutierrez Christine , Kim Yeeji , Stala Olivia 
Published: May 2020

AbstractObjectiveTo evaluate the outcomes of a children's asthma management education program delivered through a community–university partnership.DesignQuasi‐experimental pretest/posttest.SampleConvenience sample of 50 children with asthma, grades 2–5, and their parent/caregiver from nine elementary schools in New York State.MeasurementsChild Asthma Management Self‐Efficacy Survey, Child Asthma Control Test©, Parent Asthma Knowledge Test.InterventionNursing students certified as Open Airways for Schools facilitators administered the program once weekly for 5 weeks. Parent handouts were sent home after each session. Pre/posttests for all measures were completed prior to Open Airways and at completion.ResultsImproved asthma management self‐efficacy (p < .001) and improved asthma control (p = .013) for children with asthma were noted. Parent asthma knowledge was high pre‐ and posttest with no significant change. Parental knowledge regarding inhaled corticosteroids was consistently low.ConclusionsCollaboration between universities and local school systems allows for mutually beneficial exchange of knowledge and resources to address the need for asthma self‐management for children with asthma. Nursing students trained in asthma management develop expertise and provide sustainable resources for this education.
Reframing Resilience: Equitable Access to Essential Services
Authors: Logan Tom M. , Guikema Seth D. 
Published: May 2020

AbstractWe urgently need to put the concept of resilience into practice if we are to prepare our communities for climate change and exacerbated natural hazards. Yet, despite the extensive discussion surrounding community resilience, operationalizing the concept remains challenging. The dominant approaches for assessing resilience focus on either evaluating community characteristics or infrastructure functionality. While both remain useful, they have several limitations to their ability to provide actionable insight. More importantly, the current conceptualizations do not consider essential services or how access is impaired by hazards. We argue that people need access to services such as food, education, health care, and cultural amenities, in addition to water, power, sanitation, and communications, to get back some semblance of normal life. Providing equitable access to these types of services and quickly restoring that access following a disruption are paramount to community resilience. We propose a new conceptualization of community resilience that is based on access to essential services. This reframing of resilience facilitates a new measure of resilience that is spatially explicit and operational. Using two illustrative examples from the impacts of Hurricanes Florence and Michael, we demonstrate how decisionmakers and planners can use this framework to visualize the effect of a hazard and quantify resilience‐enhancing interventions. This “equitable access to essentials” approach to community resilience integrates with spatial planning, and will enable communities not only to “bounce back” from a disruption, but to “bound forward” and improve the resilience and quality of life for all residents.
Causal Isotonic Regression
Authors: Westling Ted , Gilbert Peter , Carone Marco 
Published: May 2020

SummaryIn observational studies, potential confounders may distort the causal relationship between an exposure and an outcome. However, under some conditions, a causal dose–response curve can be recovered by using the G-computation formula. Most classical methods for estimating such curves when the exposure is continuous rely on restrictive parametric assumptions, which carry significant risk of model misspecification. Non-parametric estimation in this context is challenging because in a non-parametric model these curves cannot be estimated at regular rates. Many available non-parametric estimators are sensitive to the selection of certain tuning parameters, and performing valid inference with such estimators can be difficult. We propose a non-parametric estimator of a causal dose–response curve known to be monotone. We show that our proposed estimation procedure generalizes the classical least squares isotonic regression estimator of a monotone regression function. Specifically, it does not involve tuning parameters and is invariant to strictly monotone transformations of the exposure variable. We describe theoretical properties of our proposed estimator, including its irregular limit distribution and the potential for doubly robust inference. Furthermore, we illustrate its performance via numerical studies and use it to assess the relationship between body mass index and immune response in human immunodeficiency virus vaccine trials.
Can We Know Substances? Suárez on a Sceptical Puzzle
Authors: Perler Dominik 
Published: May 2020

AbstractIt has often been said that the knowability of substances became a problem in the early modern period, when anti‐Aristotelians doubted that we could know anything more than the sensory qualities that are present to us. This article argues that the late scholastic Aristotelian Francisco Suárez was already aware of this sceptical problem. On his view, substances are really (and not just modally) distinct from the perceivable qualities, and therefore cannot be known through sense perception. The article first examines the metaphysical theory that motivated him to defend this thesis. It then looks at the epistemological consequences he drew from it. Though he rejected direct knowledge of substances, he nevertheless conceded that knowledge can be obtained through a “discursive process”. The article explores this process, spelling out all the cognitive steps it involves. In particular, it analyses Suárez's explanation of how we produce special cognitive devices (the “intelligible species”) that enable us to represent substances. Finally, it assesses Suárez's solution to the knowability problem by comparing it to Locke's solution. It argues that metaphysical rationalism led him to posit substances: we need to accept them as active causes and bearers of qualities, although we have no direct access to them.
Radiographic differentiation of mediastinal versus pulmonary masses in dogs and cats can be challenging
Authors: Ruby Jennifer , Secrest Scott , Sharma Ajay 
Published: May 2020

AbstractThe ability to differentiate thoracic masses of mediastinal and pulmonary origins is often confounded by their complex spatial relationship. The objectives of this retrospective, observational cross‐sectional study were to assess radiographic differentiation of mediastinal versus pulmonary masses, and to determine if there are any correlations with specific radiographic findings. Thoracic radiographs of 75 dogs and cats with mediastinal and/or pulmonary masses identified on CT were reviewed. Radiographic studies were anonymized, randomized, and reviewed twice by three reviewers. Reviewers categorized the origin of each mass(es) as mediastinal, pulmonary, or both. On the second review, the presence or absence of 21 different radiographic findings was recorded for each mass. Agreement between the radiographic and CT categorization of mass origin, as well as inter‐ and intraobserver agreement, was calculated. Overall agreement between radiographs and CT was moderate for both mediastinal (68.6%) and pulmonary masses (63%). Overall, interobserver agreement was moderate (κ = 0.50‐0.74), with moderate to strong intraobserver agreement (κ = 0.58‐0.93). Masses within the mediastinum were significantly more likely to displace other mediastinal structures. Alternatively, masses lateral to midline and in the caudal thorax were found to be significantly positively correlated with a pulmonary origin. The results of this study highlight the limitations of radiography for differentiation of mediastinal and pulmonary masses, with mass location and displacement of other mediastinal structures potentially useful for radiographic findings that may help improve accuracy.
Effect of herbicides and doses on short‐ and long‐term control of Eleusine tristachya
Authors: Brunori Alejandro M. , Puricelli Eduardo C. 
Published: May 2020

AbstractIn Argentina, Eleusine tristachya has been recently reported as a problematic weed that can occur at high densities in spring and summer in fallows and in maize and soyabean. The reason for the increase in E. tristachya populations is that once the weed is established, it is difficult to eliminate because it produces a high number of seeds and plant regrowth occurs after herbicide treatments. The aim of this study was to determine the effect of post‐emergence application of herbicides (glyphosate, haloxyfop‐methyl and clethodim) at the seedling, vegetative and reproductive stages on the short‐term (biomass 30 days after treatment—30 DAT) and long‐term (tiller number and height and seed production—regrowth at 330 DAT) control of E. tristachya selected biotypes in outdoor pot experiments. Data fitted to a log‐logistic model. For all the herbicides considered, at the seedling and vegetative stages, short‐term control was achieved with low ED50 and ED90 values, whereas at the reproductive stage, ED90 values were three‐ to sixfold (glyphosate), six‐ to 52‐fold (haloxyfop‐methyl) and five‐ to 13‐fold (clethodim) higher. Long‐term control at the recommended dose or lower was not possible at the reproductive stage as tiller regrowth and seed production occurred with all herbicides. It is advisable to control Eleusine tristachya when plants are small at the beginning of the growing season using the recommended herbicide dose. A delayed application will produce tiller regeneration the following year, and consequently, control would only be achieved applying an overdose, which can cause risks to health and the environment. We concluded that a management programme based on the combination of glyphosate with post‐emergence graminicides applied at early stages will be effective to control future infestations.
Developing a core outcome set for interventions to improve discharge from mental health inpatient services: a survey, Delphi and consensus meeting with key stakeholder groups
Authors: Tyler Natasha , Wright Nicola , Grundy Andrew , Waring Justin 
Published: May 2020

ObjectiveTo develop a core set of outcomes to be used in all future studies into discharge from acute mental health services to increase homogeneity of outcome reporting.DesignWe used a cross-sectional online survey with qualitative responses to derive a comprehensive list of outcomes, followed by two online Delphi rounds and a face-to-face consensus meeting.SettingThe setting the core outcome set applies to is acute adult mental health.ParticipantsParticipants were recruited from five stakeholder groups: service users, families and carers, researchers, healthcare professionals and policymakers.InterventionsThe core outcome set is intended for all interventions that aim to improve discharge from acute mental health services to the community.ResultsNinety-three participants in total completed the questionnaire, 69 in Delphi round 1 and 68 in round 2, with relatively even representation of groups. Eleven participants attended the consensus meeting. Service users, healthcare professionals, researchers, carers/families and end-users of research agreed on a four-item core outcome set: readmission, suicide completed, service user-reported psychological distress and quality of life.ConclusionImplementation of the core outcome set in future trials research will provide a framework to achieve standardisation, facilitate selection of outcome measures, allow between-study comparisons and ultimately enhance the relevance of trial or research findings to healthcare professionals, researchers, policymakers and service users.
Focus group discussions on low-flow oxygen and bubble CPAP treatments among mothers of young children in Malawi: a CPAP IMPACT substudy
Authors: Sessions Kristen L , Ruegsegger Laura , Mvalo Tisungane , Kondowe Davie , Tsidya Mercy , Hosseinipour Mina C , Lufesi Norman , Eckerle Michelle , Smith Andrew Gerald , McCollum Eric D 
Published: May 2020

ObjectiveTo determine the acceptability of bubble continuous positive airway pressure (bCPAP) and low-flow oxygen among mothers of children who had received either therapy.SettingA district hospital in Salima, Malawi.ParticipantsWe conducted eight focus group discussions (FGDs) with a total of 54 participants. Eligible participants were mothers of children 1 to 59 months of age with severe pneumonia and a comorbidity (HIV-infection, HIV-exposure, malnutrition or hypoxaemia) who, with informed consent, had been enrolled in a randomised clinical trial, CPAP IMPACT (Improving Mortality for Pneumonia in African Children Trial), comparing low-flow oxygen and bCPAP treatments (ClinicalTrials.gov,NCT02484183).Primary and secondary outcome measuresFGDs assessed mothers’ attitudes and feelings towards oxygen and bCPAP before and after therapy along with general community perceptions of respiratory therapies. Data was analysed using inductive thematic analysis to assess themes and subthemes of the transcripts.ResultsCommunity perceptions of oxygen and bCPAP were widely negative. Mothers recounted that they are told that ‘oxygen kills babies’. They are often fearful of allowing their child to receive oxygen therapy and will delay treatment or seek alternative therapies. Mothers report limiting oxygen and bCPAP by intermittently removing the nasal cannulas or mask. After oxygen or bCPAP treatment, regardless of patient outcome, mothers were supportive of the treatment their child received and would recommend it to other mothers.ConclusionThere are significant community misconceptions around oxygen and bCPAP causing mothers to be fearful of either treatment. In order for low-flow oxygen treatment and bCPAP implementation to be effective, widespread community education is necessary.
Epidemiological characteristics of HIV infection among college students in Nanjing, China: a cross-sectional survey
Authors: Li Wei , Chu Jinjin , Zhu Zhengping , Li Xin , Ge You , He Yan , Ni Qian , Musa Taha , Li Xiaoshan , Wei Pingmin 
Published: May 2020

ObjectiveThis study aimed to investigate the epidemiological characteristics and HIV/AIDS-related knowledge, attitudes and practice (KAP) among HIV-positive college students.DesignA cross-sectional study.SettingFive districts of Nanjing, China.ParticipantsA total of 156 college students with newly diagnosed HIV infection between September 2015 and July 2017.Main outcome measuresSocial-demographic characteristics, mode of HIV acquisition, infection of sexually transmitted diseases, risky sexual behaviours and HIV/AIDS-related KAP were collected by a face-to-face questionnaire administered by trained interviewers.ResultsAbout 98.7% (154/156) of HIV-positive college students in our study were men, and 96.1% (148/154) of them were infected by sexual intercourse with men. More than half (52.5%, 82/156) of participants were freshmen or sophomores. Nearly 30% (44/154) of male students did not realise the severe status of the HIV/AIDS epidemic among students who are men who have sex with men (MSM). More than four-fifths of male students did not know if their male regular (83.0%, 93/112) or casual (95.9%, 94/98) sexual partners were HIV-positive, while less than half of them had high-risk perceptions towards HIV infection from male regular and occasional sexual partners. Approximately one-half and four-fifths of male students had more than two regular (54.5%, 61/112) and occasional (79.6%, 78/98) partners during lifetime, respectively. However, only 62.5% (70/112) and 66.3% (65/98) of male students used condoms consistently during sexual intercourse with regular and casual partners, respectively. Geosocial networking apps have become the most dominant way for male students to seek sexual partners.ConclusionsThis study reported a low level of HIV/AIDS-related knowledge, a high level of exposure to risky sexual behaviours and some valuable epidemiological characteristics among HIV-positive college students, which highlighted the importance of carrying out HIV/AIDS prevention education and risk warning education early and timely towards college students on campus.
Aetiological and morphological spectrum of cardiomyopathies in French Guiana: a retrospective study
Authors: Leménager Paul , Franck Yves-Kenol , Corlin Florine , Bouscaren Nicolas , Nacher Mathieu , Adenis Antoine 
Published: May 2020

IntroductionCardiomyopathies are a heterogeneous heart diseases group in terms of morphology and aetiology. Hypothesising a tropical specificity and given an absence of data in French Guiana, the primary objective of our study was to describe morphologies and aetiologies of cardiomyopathies observed at Cayenne General Hospital.MethodsA cross-sectional study was conducted in Cayenne Hospital from 1 January 2009 to 1 June 2014 in the hospital database. Only patients with the definition of the European Society of Cardiology (ESC) were included, based on the first transthoracic ultrasonography found during the study period. Medical files were consulted.ResultsWith 182 patients included, the prevalence of cardiomyopathies among heart diseases was estimated at 4.3% (95% CI 3.7% to 4.9%). Twelve patients had a familial or genetic aetiology (6.6%) and 170 a non-familial or non-genetic aetiology (93.4%). The morphological spectrum was: dilated for 114 patients (62.6%), hypertrophic for 27 (14.8%), unclassified for 1 (0.5%) and non-classifiable for 13 (7.1%). This group was constituted of patients with a systolic and/or diastolic functional impairment without morphological abnormality. The aetiological spectrum found 184 aetiologies including: 70.9% undetermined, 8.7% infectious (with 6.5% chagasic and 0.5% related with human immunodeficiency virus) and 6.0% with toxins.ConclusionsCardiomyopthies are a common and severe clinical problem. The frequency of infectious aetiologies and dilated impairment are arguments for cardiomyopathies with tropical particularities. However, the preponderance of undetermined aetiologies justifies the development of further research programmes.
Static and dynamical elastic behavior of Lu5Ir4Si10 around its first-order structural phase transition
Authors: Saint-Paul M. , Opagiste C. , Guttin C. 
Published: May 2020

Ultrasonic velocity measurements could be performed on a good quality single crystal of [Formula: see text] around its transition around 80 K. The behavior of the stiffness components demonstrates a first-order transition. The temperature dependence of the longitudinal elastic stiffness components [Formula: see text] and [Formula: see text] can be analyzed by the classical Landau theory and assuming a stricter coupling between the strain and the order parameter. A theoretical approach and experimental results are discussed.
Preclinical Characterization of an Antibody–Drug Conjugate Targeting CS-1 and the Identification of Uncharacterized Populations of CS-1–Positive Cells
Authors: Chen Ruoyan , Rajan Saravanan , Overstreet Michael G. , Hurt Elaine M. , Thomas Suneetha B. , Muniz-Medina Vanessa , Ward Christopher , Sadowska Agnieszka , Fleming Ryan , Karanth Subramanya , Breen Shannon , Zheng Bo , Wu Yuling , Iverson William O. , Novick Steven , O'Day Terrence , Shah Dipesha P. , Dimasi Nazzareno , Tiberghien Arnaud C. , Osbourn Jane , Walker Jill 
Published: May 2020

Abstract
Multiple myeloma is a hematologic cancer that disrupts normal bone marrow function and has multiple lines of therapeutic options, but is incurable as patients ultimately relapse. We developed a novel antibody–drug conjugate (ADC) targeting CS-1, a protein that is highly expressed on multiple myeloma tumor cells. The anti–CS-1 mAb specifically bound to cells expressing CS-1 and, when conjugated to a cytotoxic pyrrolobenzodiazepine payload, reduced the viability of multiple myeloma cell lines in vitro. In mouse models of multiple myeloma, a single administration of the CS-1 ADC caused durable regressions in disseminated models and complete regression in a subcutaneous model. In an exploratory study in cynomolgus monkeys, the CS-1 ADC demonstrated a half-life of 3 to 6 days; however, no highest nonseverely toxic dose was achieved, as bone marrow toxicity was dose limiting. Bone marrow from dosed monkeys showed reductions in progenitor cells as compared with normal marrow. In vitro cell killing assays demonstrated that the CS-1 ADC substantially reduced the number of progenitor cells in healthy bone marrow, leading us to identify previously unreported CS-1 expression on a small population of progenitor cells in the myeloid–erythroid lineage. This finding suggests that bone marrow toxicity is the result of both on-target and off-target killing by the ADC.
Endovascular Intervention Versus Surgery in Ruptured Intracranial Aneurysms in Equipoise
Authors: Chai Chung Liang , Pyeong Jeon Jin , Tsai Yi-Hsin , Whittaker Paula , Macdonald R. Loch , Lindgren Antti E. , Ayling Oliver G.S. , Acioly Marcus André , Cohen-Gadol Aaron , Huang Yu-Hua 
Published: May 2020

Background and Purpose—
The benefits of endovascular intervention over surgery in the treatment of ruptured aneurysms of anterior circulation remains uncertain. Recently, published studies did not find superiority of endovascular intervention, challenging earlier evidence from a clinical trial. The earlier evidence also had a higher than average proportion of patients in good clinical status, leading to uncertainty about external validity of earlier trials.

Methods—
We performed a systematic review of studies after 2005 under a protocol published in the International Prospective Register of Systematic Reviews. Primary outcomes were posttreatment rebleeding and adverse events (procedural complications). Secondary outcomes were dependency at 3 to 6 and 12 months, delayed cerebral ischemia, and seizures.

Results—

Rebleeding was more frequent after endovascular intervention (Peto OR, 2.18 [95% CI, 1.29–3.70]; 3104 participants; 15 studies; I
2
=0%, Grading of Recommendations, Assessment, Development and Evaluation: very low certainty of evidence). Fewer adverse events were reported with the endovascular intervention (RR, 0.71 [95% CI, 0.53–0.95]; 1661 participants; 11 studies; I
2
=14%, Grading of Recommendations, Assessment, Development and Evaluation: low certainty of evidence). Three to six months dependency (RR, 0.82 [95% CI, 0.73–0.93]; 4081 participants; 18 studies; I
2
=15%, Grading of Recommendations, Assessment, Development and Evaluation: low certainty of evidence) and 12-month dependency (RR, 0.76 [95% CI, 0.66–0.86]; 1981 participants; 10 studies; I
2
=0%, Grading of Recommendations, Assessment, Development and Evaluation: low certainty of evidence) were lower after endovascular intervention.

Conclusions—
This study found consistent results between recent studies and the earlier evidence, in that endovascular intervention results in lower chance of dependency compared with surgery for repair of ruptured anterior circulation aneurysms. A lower proportion of patients in good clinical status in this review supports the application of the earlier evidence.

Registration—

URL:
https://www.crd.york.ac.uk/PROSPERO
. Unique identifier: CRD42018090396.