bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychiatric problems and its contributing factors in children and adolescents with hemophilia: a single centre study in a Turkish sample
Authors: Cikili-Uytun Merve , Çetin Fatih Hilmi , Yılmaz Rabia , Uytun Salih , Babadağı Zehra , Karadogan Meriban , Mutlu Fatma Turkan , Altuner-Torun Yasemin 
Published: July 2020

Abstract
Background
We aimed to evaluate the psychiatric symptoms in addition quality of life in children and adolescents with hemophilia and to determine which factors contributed to psychiatric problems of them.
A total of 20 children and adolescents with hemophilia A or B and 20 healthy controls, aged 6–16 years old, were included. Kiddie-Schedule for Affective Disorders and Schizophrenia, present and life time version (K-SADS-PL) was applied to parents. Sociodemographic questionnaire, Child Depression Inventory (CDI), The Spielberger State-Trait Anxiety Inventory (STAI), and KINDLR Questionnaire was used for children and adolescents in both groups. Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and KINDL parent form were used for mothers in both groups.

Results
The study results demonstrated higher anxiety scores and increased anxiety disorder diagnosis among children and adolescents with hemophilia. However, mother’s anxiety and depression scores are higher than control group, and QoL of their children also shows lower scores in parents’ KINDL forms. Mothers’ depression and anxiety scores are associated with childrens’ depression, anxiety, and QoL scores.

Conclusion
Psychiatric factors should not be ignored in the treatment and follow-up of children and adolescents with hemophilia and their parents.
Accuracy of Exercise-based Equations for Estimating Cardiorespiratory Fitness
Authors: PETERMAN JAMES E. , HARBER MATTHEW P. , IMBODEN MARY T. , WHALEY MITCHELL H. , FLEENOR BRADLEY S. , MYERS JONATHAN , ARENA ROSS , KAMINSKY LEONARD A. 
Published: July 2020

ABSTRACT
Equations are often used to predict cardiorespiratory fitness (CRF) from submaximal or maximal exercise tests. However, no study has comprehensively compared these exercise-based equations with directly measured CRF using data from a single, large cohort.

Purpose
This study aimed to compare the accuracy of exercise-based prediction equations with directly measured CRF and evaluate their ability to classify an individual’s CRF.

Methods
The sample included 4871 tests from apparently healthy adults (38% female, age 44.4 ± 12.3 yr (mean ± SD)). Estimated CRF (eCRF) was determined from 2 nonexercise equations, 3 submaximal exercise equations, and 10 maximal exercise equations; all eCRF calculations were then compared with directly measured CRF, determined from a cardiopulmonary exercise test. Analysis included Pearson product–moment correlations, standard error of estimate values, intraclass correlation coefficients, Cohen κ coefficients, and the Benjamini–Hochberg procedure to compare eCRF with directly measured CRF.

Results
All eCRF values from the prediction equations were associated with directly measured CRF (P < 0.01), with intraclass correlation coefficient estimates ranging from 0.07 to 0.89. Although significant agreement was found when using eCRF to categorize participants into fitness tertiles, submaximal exercise equations correctly classified an average of only 51% (range, 37%–58%) and maximal exercise equations correctly classified an average of only 59% (range, 43%–76%).

Conclusions
Despite significant associations between exercise-based prediction equations and directly measured CRF, the equations had a low degree of accuracy in categorizing participants into fitness tertiles, a key requirement when stratifying risk within a clinical setting. The present analysis highlights the limited accuracy of exercise-based determinations of eCRF and suggests the need to include cardiopulmonary measures with maximal exercise to accurately assess CRF within a clinical setting.
Análisis de la influencia del Índice de Masa Corporal en la evolución de la Insuficiencia Cardíaca en una Zona de Salud
Authors: Tarraga Lopez Pedro J 
Published: July 2020

Introducción: Analizar las diferentes variables del Índice de Masa Corporal (IMC) en relación con la evolución de la Insuficiencia cardíaca en una zona de salud.Material y métodos: Estudio descriptivo observacional y analítico de los 161 pacientes diagnosticados en la zona de salud entre enero de 2014 y diciembre de 2016. Se analizaron datos demográficos, clínicos, y analíticos. Se calculó el IMC a partir del peso y la talla en la primera visita a la consulta, mediante la fórmula: peso (kg) / cuadrado de la talla (m). Una vez obtenido se evaluó la relación entre el IMC y la evolución en 2 años. Se estudió a 4 subgrupos de pacientes, en función de su IMC, a partir de los criterios definidos por la Organización Mundial de la Salud (OMS) en 1999: bajo peso (IMC < 20,5), peso normal (IMC de 20,5 a < 25,5), sobrepeso (IMC de 25,5 a < 30) y obesidad (IMC ≥ 30).Resultados: 81 participantes eran obesos (50,8%), 33 hombres y 48 mujeres. La edad media de los obesos fue de 80,32 (9,23) años. Un 62,2% tenía diagnosticado algún tipo de cardiopatía, siendo: 29,2% cardiopatía isquémica; 46,6% arritmias cardiacas y 20,5% valvulopatías. El IMC, como variable continua, se asoció de forma significativa con la mortalidad (p < 0,001), la edad (0,002), la enfermedad isquémica (0,001), sexo (0,004), hipertensión (0,002), diabetes (0,003) y dislipemia (0,004). También se vio relación directamente proporcional del IMC con el uso de tratamientos con digoxina, diuréticos de asa y espironolactona. EL IMC también se asoció con el número de ingresos, mayor número de enfermedades crónicas concomitantes y mortalidad. Los pacientes con obesidad obtuvieron peores puntuaciones en el cuestionario de calidad de vida MLWHFQ.Conclusiones: El IMC mostró asociación con la mortalidad, la enfermedad isquémica, el sexo, la hipertensión, diabetes y dislipemia en pacientes con insuficiencia cardiaca.
Relación entre las características de la composición corporal y el rendimiento físico general y específico en competidores de taekwondo chilenos de nivel nacional de ambos sexos: un estudio observacional
Authors: Ojeda-Aravena Alex , Azocar-Gallardo Jairo , Galle Fernando , García-García Jose Manuel 
Published: July 2020

Introducción: El objetivo fue examinar la relación entre las características de la composición corporal y el rendimiento físico general y específico en competidores de TKD de nivel nacional de Chile de ambos sexos. Material y métodos: Diseño observacional con 14 competidores de diferentes categorías de peso corporal y que compiten habitualmente en torneos de nivel regional y nacional edad 19 (3) años; talla 164 (10) cm; peso corporal 62 (10) kg; años de experiencia 7,2 (2,9) años participaron en este estudio. Se evaluaron el peso corporal (kg) (PC), la masa grasa (kg), (MG), el porcentaje de masa grasa (%MG), la masa muscular (kg) (MM) y el índice de masa corporal (kg/m2) (IMC). Variables del RF general incluyeron squat jump (cm) (SJ), countermovement jump (cm) (CMJ), velocidad lineal en 5-m (s) (5-M) y 20-m shuttle run test (min) (20MSR) y de forma específica la prueba de agilidad específica en taekwondo (s) (TSAT) y la prueba de velocidad de frecuencia múltiple de patadas (FSKTMULT), específicamente el índice de disminución de patadas (FSKTMULT KDI %) y el número máximo de patadas ejecutadas (FSKTMULT MAX). Resultados: Se documentó una relación grande significativa (p < 0,00) entre el %MG, la MG y la MM y la mayoría de las variables de rendimiento físico general analizadas. Relaciones grandes significativas (p < 0,05) se observaron entre %MG, la MG y la MM y la prueba TSAT. Una relación grande significativa se documentó entre la MM y FSKTMULT MAX (p<0,03) y entre la MG y FSKTMULT KDI % (p<0,04). Correlaciones moderadas a bajas se observaron entre el PC y el IMC en la mayoría de las variables de rendimiento físico analizadas. Conclusiones: Los datos sugieren que un bajo %MG y MG seguido de una adecuada MM están relacionados con el rendimiento físico general específico en competidores chilenos de TKD de nivel nacional de ambos sexos.
Análisis de las propiedades físico-químicas y sensoriales de barra alimenticia a base de semillas y nueces sin componentes de origen animal
Authors: Toscano-Palomar Lydia , García-Gómez Gilberto , Gómez-Puentes Francisco J. , Beltrán-González Guillermo , Valenzuela-Espinoza Iracema G. , Armenta-Gálvez Jesus M. 
Published: July 2020

Introducción: La necesidad de alimentos nutritivos se ha incrementado por la demanda de un público exigente. Los consumidores, en la actualidad, desean aperitivos que además de satisfacer su apetito, aporten también nutrientes esenciales. Este trabajo tuvo como objetivo la caracterización físico-química de una barra alimenticia elaborada a base de semillas (girasol, ajonjolí, chía y linaza) y nueces (almendra, nuez de la India, corazón de nuez de pecana, pistache y nuez de Castilla entera) libre de componentes de origen animal, como leche de vaca en polvo, ovoalbúmina y/o grasas animales utilizados en barras alimenticias comerciales.Material y métodos: Los métodos de análisis próximo, valor energético, vida útil de la barra alimenticia y análisis sensorial y las pruebas de aceptación, se realizaron de acuerdo a métodos estándares de análisis de la Asociación de Químicos Analíticos Oficiales (AOAC por sus siglas en inglés). Todos los análisis se realizaron por triplicado a menos que se indicara de otra manera. Los resultados obtenidos fueron estadísticamente analizados con un 5 % de nivel de significancia para cada prueba.Resultados: Se analizó su composición próxima (27% proteína, 7,5% fibra cruda y 4,4% de azúcares). Estos valores posicionan a este producto dentro de las barras de alto contenido proteico con contenido en azúcar muy bajo si se compara con barras comerciales (20 – 40%). Presentó el 45% de lípidos con el 19% de aceites saturados y 81 % de insaturados, todos estos derivados de las nueces y semillas. Se cuantificaron minerales esenciales como: calcio, magnesio, potasio, sodio, cobre, hierro, manganeso y zinc. La velocidad de rancidez fue relativamente baja hasta alcanzar el valor máximo permisible de 10 meq/kg en peróxidos como valor de rancidez a los 9 días de almacenamiento a 40 °C. Conclusiones: Las barras alimenticias a base de semillas y nueces tuvieron una alta aceptación en pruebas sensoriales de preferencia por público adulto. De acuerdo con estos resultados se presenta un alimento de alto contenido proteico, nutricionalmente completo y estable al almacenamiento.
Novel Insights Into Tissue-Specific Biochemical Alterations in Pediatric Eosinophilic Esophagitis Using Raman Spectroscopy
Authors: Hiremath Girish , Locke Andrea , Thomas Giju , Gautam Rekha , Acra Sari , Correa Hernan , Dellon Evan S. , Mahadevan-Jansen Anita 
Published: July 2020

INTRODUCTION:
Elucidating esophageal biochemical composition in eosinophilic esophagitis (EoE) can offer novel insights into its pathogenesis, which remains unclear. Using Raman spectroscopy, we profiled and compared the biochemical composition of esophageal samples obtained from children with active (aEoE) and inactive EoE (iEoE) with non-EoE controls, examined the relationship between spectral markers and validated EoE activity indices.

METHODS:

In vitro Raman spectra from children with aEoE (n = 8; spectra = 51) and iEoE (n = 6; spectra = 48) and from non-EoE controls (n = 10; spectra = 75) were acquired. Mann-Whitney test was used to assess the differences in their Raman intensities (median [interquartile range]) and identify spectral markers. Spearman correlation was used to evaluate the relationship between spectral markers and endoscopic and histologic activity indices.

RESULTS:
Raman peaks attributable to glycogen content (936/1,449 cm−1) was lower in children with aEoE (0.20 [0.18–0.21]) compared with that in non-EoE controls (0.24 [0.23–0.29]). Raman intensity of proteins (1,660/1,209 cm−1) was higher in children with aEoE compared with that in non-EoE controls (3.20 [3.07–3.50] vs 2.91 [2.59–3.05]; P = 0.01), whereas that of lipids (1,301/1,260 cm−1) was higher in children with iEoE (1.56 [1.49–1.63]) compared with children with aEoE (1.40 [1.30–1.48]; P = 0.02). Raman peaks attributable to glycogen and lipid inversely correlated with eosinophilic inflammation and basal zone hyperplasia. Raman mapping substantiated our findings.

DISCUSSION:
This is the first study to identify spectral traits of the esophageal samples related to EoE activity and tissue pathology and to profile tissue-level biochemical composition associated with pediatric EoE. Future research to determine the role of these biochemical alterations in development and clinical course of EoE can advance our understanding of EoE pathobiology.
The Influence of Movement Tempo on Acute Neuromuscular, Hormonal, and Mechanical Responses to Resistance Exercise—A Mini Review
Authors: Wilk Michal , Tufano James J. , Zajac Adam 
Published: July 2020

Abstract
Wilk, M, Tufano, JJ, and Zajac, A. The influence of movement tempo on acute neuromuscular, hormonal, and mechanical responses to resistance exercise—a mini review. J Strength Cond Res 34(8): 2369–2383, 2020—Resistance training studies mainly analyze variables such as the type and order of exercise, intensity, number of sets, number of repetitions, and duration and frequency of rest periods. However, one variable that is often overlooked in resistance training research, as well as in practice, is premeditated movement tempo, which can influence a myriad of mechanical and physiological factors associated with training and adaptation. Specifically, this article provides an overview of the available scientific literature and describes how slower tempos negatively affect the 1-repetition maximum, the possible load to be used, and the number of repetitions performed with a given load, while also increasing the total time under tension, which can mediate acute cardiovascular and hormonal responses. As a result, coaches should consider testing maximal strength and the maximal number of repetitions that can be performed with each movement tempo that is to be used during training. Otherwise, programming resistance training using various movement tempos is more of a trial-and-error approach, rather than being evidence or practice based. Furthermore, practical applications are provided to show how movement tempo can be adjusted for a variety of case study–type scenarios.
Physiological Demands of Professional Flat and Jump Horse Racing
Authors: Kiely Michael , Warrington Giles D. , McGoldrick Adrian , Pugh Jennifer , Cullen SarahJane 
Published: July 2020

Abstract
Kiely, M, Warrington, GD, McGoldrick, A, Pugh, J, and Cullen, S. Physiological demands of professional flat and jump horse racing. J Strength Cond Res 34(8): 2173–2177, 2020—No information is currently available on the effect of race distance on the physiological demands of jockeys. This study aimed to quantify the respective demands of short and long flat and jump race distances. Twenty professional jockeys (10 flat and 10 jump) participated in the study. The subjects initially performed a graded incremental exercise test to volitional exhaustion on a treadmill to determine the peak heart rate (HR) and blood lactate concentrations. Two competitive races (short and long) were then monitored on 2 separate occasions for each jockey type to obtain hydration, HR, blood lactate concentration, and rating of perceived exertion data. Mean distances for the 4 races were: 1,247.2 ± 184.7 m (short flat race), 2,313.4 ± 142.2 m (long flat race), 3,480.2 ± 355.3 m (short jump race), and 4,546.4 ± 194.3 m (long jump race). The mean HR for the long flat race was 151 ± 19 b·min−1 (79 ± 11% of HRpeak), which was significantly lower than all other race distances (p = 0.000, effect size [ES] = 0.469). A longer jump race resulted in a significantly higher reported rate of perceived exertion (RPE) (14 ± 2.8) than the short jump race (11.0 ± 1.5) (p = 0.009, ES = 0.271), whereas no significant difference was revealed between peak HR responses or blood lactate concentrations when comparing other race distances (p < 0.05). The finding of this study supports previous limited research, which suggests that horse racing is a high-intensity sport, whereas RPE and mean HR fluctuate according to the race distance.
Genome-Wide Association Analysis Identified ANXA1 Associated with Shoulder Impingement Syndrome in UK Biobank Samples
Authors: Cheng Bolun , Ning Yujie , Liang Chujun , Li Ping , Liu Li , Cheng Shiqiang , Ma Mei , Zhang Lu , Qi Xin , Wen Yan , Zhang Feng 
Published: July 2020

Abstract
Shoulder impingement syndrome (SIS) is a common shoulder disorder with unclear genetic mechanism. In this study, Genome-wide Association Study (GWAS) was conducted to identify the candidate loci associated with SIS by using the UK Biobank samples (including 3,626 SIS patients and 3,626 control subjects). Based on the GWAS results, gene set enrichment analysis was further performed to detect the candidate gene ontology and pathways associated with SIS. We identified multiple risk loci associated with SIS, such as rs750968 (P = 4.82 × 10−8), rs754832 (P = 4.83 × 10−8) and rs1873119 (P = 6.39 × 10−8) of ANXA1 gene. Some candidate pathways have been identified related to SIS, including those linked to infection response and hypoxia, “ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN” (P = 0.012) and “MANALO_HYPOXIA_UP” (P = 5.00 × 10−5). Our results provide novel clues for understanding the genetic mechanism of SIS.
Identification of New Regulators of the Oocyte-to-Embryo Transition inDrosophila
Authors: Avilés-Pagán Emir E , Kang Albert S W , Orr-Weaver Terry L 
Published: July 2020

AbstractAt the oocyte-to-embryo transition the highly differentiated oocyte arrested in meiosis becomes a totipotent embryo capable of embryogenesis. Oocyte maturation (release of the prophase I primary arrest) and egg activation (release from the secondary meiotic arrest and the trigger for the oocyte-to-embryo transition) serve as prerequisites for this transition, both events being controlled posttranscriptionally. Recently, we obtained a comprehensive list of proteins whose levels are developmentally regulated during these events via a high-throughput quantitative proteomic analysis of Drosophila melanogaster oocyte maturation and egg activation. We conducted a targeted screen for potential novel regulators of the oocyte-to-embryo transition, selecting 53 candidates from these proteins. We reduced the function of each candidate gene using transposable element insertion alleles and RNAi, and screened for defects in oocyte maturation or early embryogenesis. Deletion of the aquaporin gene CG7777 did not affect female fertility. However, we identified CG5003 and nebu (CG10960) as new regulators of the transition from oocyte to embryo. Mutations in CG5003, which encodes an F-box protein associated with SCF-proteasome degradation function, cause a decrease in female fertility and early embryonic arrest. Mutations in nebu, encoding a putative glucose transporter, result in defects during the early embryonic divisions, as well as a developmental delay and arrest. nebu mutants also exhibit a defect in glycogen accumulation during late oogenesis. Our findings highlight potential previously unknown roles for the ubiquitin protein degradation pathway and sugar transport across membranes during this time, and paint a broader picture of the underlying requirements of the oocyte-to-embryo transition.
Exploiting column chemistry for chromatographic separation and quantification of caffeoylquinic acids in Gynura procumbens
Authors: Murugesu Kisantini , Saghir Sultan Ayesh Mohammed , Sadikun Amirin , Khaw Kooi-Yeong , Murugaiyah Vikneswaran 
Published: July 2020

AbstractA simple and sensitive high-performance liquid chromatography-ultraviolet (HPLC-UV) method was developed by exploiting the benefits of phenyl-hexyl column for the simultaneous determination of mono- and di-caffeoylquinic acids in Gynura procumbens plant samples. An optimal chromatographic separation was achieved by using a mobile phase of acetonitrile: 0.25% acetic acid in water (12.5:78.5, v/v) and detection at 330 nm. The limits of detection (LOD) and quantification (LOQ) for the six caffeoylquinic acid standards were in the range of 0.078–0.653 and 0.259–1.795 μg/mL, respectively. The accuracies of the developed method were in the range of 96.84–103.08%, while the corresponding precisions were between 0 and 2.94% for both within-day and between-day analyses, indicating that the method is repeatable and reliable. The mean recoveries were between 87.08 and 117.83%. The method was successfully applied for quantification of caffeoylquinic acids in G. procumbens plant samples. This is the first study on di-caffeoylquinic acids quantification in G. procumbens. Leaves samples contained higher amount of the caffeoylquinic acids compared to stem samples. Of the compounds, 3,5-dicaffeoylquinic acid was found to be the major compound in almost all G. procumbens samples. The method has advantages such as sensitive ultraviolet (UV) detection, short run time with simple isocratic elution system compared to other methods which involved the use of costly instruments, laborious procedures with long run time and complex gradient system. This method can be further extended for routine quality control and analysis of plants or herbal products containing the caffeoylquinic acids.
Observing the effects of hands-on activities on mathematics teacher confidence in geometry and statistics: A case study
Authors: Hurdle Zachariah Benton 
Published: July 2020

Middle school mathematics teachers often do not emphasise statistics and geometry in their lesson plans for a variety of reasons. However, these are integral topics in mathematics, and using direct lecture or hands-on activities may have different effects on teacher confidence when approaching these subjects. Using qualitative and quantitative methods, anxiety was found to improve with lecture-based workshops, while confidence and effectance was found to improve with manipulatives-based workshops. The results showed some surprising and unsurprising reasons for these conclusions.

Key words: teacher education; math anxiety; manipulatives; geometry; statistics