bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disentangling principled and opportunistic motives for reacting to injustice: A genetically-informed exploration of justice sensitivity
Authors: Eftedal Nikolai Haahjem , Kleppestø Thomas Haarklau , Czajkowski Nikolai Olavi , Sheehy-Skeffington Jennifer , Røysamb Espen , Vassend Olav , Ystrom Eivind , Thomsen Lotte 
Published: June 2020

AbstractMoral judgments may be driven by both principled and opportunistic motivations. Being morally principled is to consistently adhere to a single set of rules about morality and justice. Opportunistic morality rather involves selectively enforcing rules when they are beneficial to one’s interests. These two kinds of motivations sometimes pull in the same direction, other times not. Prior studies on moral motivations have mostly focused on principled morality. Opportunistic morality, along with its phenotypic and genetic correlates, remains largely unexamined. Here, utilizing a sample from the Norwegian Twin Registry, consisting of 312 monozygotic-and 298 dizygotic twin pairs (N = 1220), we measure people’s propensity to react to injustice as victims, observers, beneficiaries, and perpetrators of injustice, using the Justice Sensitivity scale. Our genetically informative sample allows a biometric modeling approach that provides increased stringency in inferring latent psychological traits. We find evidence for two substantially heritable traits explaining correlations between Justice Sensitivity facets, which we interpret as aprincipled justice sensitivity(h2= .45) leading to increased sensitivity to injustices of all categories, and anopportunistic justice sensitivity(h2= .69) associated with increased victim sensitivity and a decreased propensity to feel guilt from being a perpetrator. These heritable justice traits share a genetic substrate with broad strategies for cooperation (as measured by altruism and trust) and for selectively benefitting oneself over the adaptive interests of others (as measured by social dominance orientation and support for monopolizing territory and resources), and differ genetically and phenotypically from Big Five personality traits.
Eukarion-134 attenuates endoplasmic reticulum stress-induced mitochondrial dysfunction in human skeletal muscle cells
Authors: Thoma Anastasia , Lyon Max , Al-Shanti Nasser , Nye Gareth A , Cooper Robert G , Lightfoot Adam P 
Published: June 2020

ABSTRACTMaladaptive endoplasmic reticulum (ER) stress is associated with modified reactive oxygen species (ROS) generation, altered mitochondrial bioenergetics, and oxidative damage; and is postulated as a potential mechanism involved in the underlying muscle weakness experienced by patients with myositis, an acquired autoimmune neuromuscular disease. In this study, we investigate the impact of ROS generation in anin vitromodel of ER stress in skeletal muscle, using the ER stress inducer tunicamycin (24 hours) in presence or absence of a superoxide dismutase/catalase mimetic Eukarion (EUK)-134. ER stress activation, ROS generation, mitochondrial function, biogenesis, morphology and dynamics (fusion/fission) were examined. Tunicamycin induced maladaptive ER stress, validated by stimulation of GRP94, GRP78, CHOP, XBP-1, ERDJ4, and GADD34, which were mostly mitigated by EUK-134 at transcriptional level. ER stress triggered mitochondrial unfolded protein response and promoted mitochondrial dysfunction, described by substantial loss of mitochondrial membrane potential, as well as reduction of respiratory control ratio, reserve capacity, phosphorylating respiration, and coupling efficiency, which was ameliorated by EUK-134. ROS-mediated biogenesis and fusion of mitochondria was evident in presence of tunicamycin, which however, had high propensity of fragmentation, accompanied by upregulated mRNA levels of fission-related markers. Increased cellular ROS generation oxidative stress was observed in response to ER stress that was ameliorated in the presence of EUK-134, even though no changes in mitochondrial superoxide were noticeable. These findings suggest that targeting ROS generation using the superoxide dismutase/catalase mimetic EUK-134 can amend aspects of ER stress-induced changes in mitochondrial dynamics and function. Overall, this study suggests that in instances of chronic ER stress, such as in myositis, quenching ROS generation may be a promising therapy for muscle weakness and dysfunction.
Does the Freeze-all strategy improve the cumulative live birth rate and the time to become pregnant in IVF cycles?
Authors: Johnson S. , Vandromme J. , Larbuisson A. , Raick D. , Delvigne A. 
Published: June 2020

IntroductionFreezing of all good quality embryos and their transfer in subsequent cycles, named the freeze-all strategy (FAS), is widely used for ovarian hyperstimulation syndrome (OHSS) prevention. Indeed, it increases live birth rates among high responders and prevents preterm birth and small for gestational age. Consequently, why shouldn’t we extend it to all?Materials and methodsA retrospective and monocentric study was conducted between January 2008 and January 2018 comparing the cumulative live birth rates (CLBR) between patients having undergone FAS and a control group using fresh embryo transfer (FET) and having at least one frozen embryo available. Analyses were made for the entire cohort (population 1) and for different subgroups according to confounding factors selected by a logistic regression (population 3), and to the BELRAP (Belgian Register for Assisted Procreation) criteria (population 2).Results2216 patients were divided into two groups: Freeze all (FA), 233 patients and control (C), 1983 patients. The CLBR was 50.2% vs 58.1% P=0.021 for population 1 and 53.2% vs 63.3% P=0.023 for population 2, including 124 cases and 1241 controls. The CLBR stayed in favour of the C group: 70.1% vs 55.9% P=0.03 even when confounding variables were excluded (FA and C group respectively 109 and 770 patients). The median time to become pregnant was equally in favour of the C group with a median of 5 days against 61 days.ConclusionsCLBR is significantly lower in the FA group compared to the C group with a longer time to become pregnant. Nevertheless, the CLBR in the FA group remains excellent and superior to that observed in previous studies with similar procedures and population. These results confirm the high efficiency of FAS but underline the necessity to restrict the strategy to selected cases.
Light-activated signaling in DNA-encoded sender-receiver architectures
Authors: Yang Shuo , Pieters Pascal A. , Joesaar Alex , Bögels Bas W.A. , Brouwers Rens , Myrgorodska Iuliia , Mann Stephen , de Greef Tom F.A. 
Published: June 2020

AbstractCollective decision making by living cells is facilitated by exchange of diffusible signals where sender cells release a chemical signal that is interpreted by receiver cells. Biologists have started to unravel the underlying physicochemical determinants that control the effective communication distance using genetically modified cells. However, living systems are inherently challenging to manipulate and study systematically and quantitatively. Therefore, the development of generic and tunable abiotic mimics featuring compartmentalized signaling is highly desirable. Here, by adapting a previously reported artificial cell-cell communication system, we engineer DNA-encoded sender-receiver architectures, where protein-polymer microcapsules act as cell mimics and molecular communication occurs through diffusive DNA signals. We prepare spatial distributions of sender and receiver protocells using a microfluidic trapping array, and setup a signaling gradient from a single sender cell using light, which activates surrounding receivers through DNA strand displacement. Our systematic analysis reveals how the effective signal range of a single sender is determined by various factors including the density and permeability of receivers, extracellular signal degradation, signal consumption and catalytic regeneration. In addition, we construct a three-population configuration where two sender cells are embedded in a dense array of receivers that implement Boolean logic and investigate spatial integration of non-identical input cues. The results advance our understanding of diffusion-based sender-receiver topologies and present a strategy for constructing spatially controlled chemical communication systems that have the potential to reconstitute collective cellular behavior.
Direct energy transfer from photosystem II to photosystem I is the major regulator of winter sustainability of Scots pine
Authors: Bag Pushan , Chukhutsina Volha , Zhang Zishan , Paul Suman , Ivanov Alexander G. , Shutova Tatyana , Croce Roberta , Holzwarth Alfred R. , Jansson Stefan 
Published: June 2020

AbstractEvergreen conifers in boreal forests can survive extremely cold (freezing) temperatures during the long dark winter and fully recover during the summer. A phenomenon called ‘sustained quenching’ putatively provides photoprotection and enables their survival, but its precise molecular and physiological mechanisms are not understood. To unveil them, we have analyzed the seasonal adaptation of the photosynthetic machinery of Scots pine (Pinus sylvestris) trees by monitoring multi-year changes in weather, chlorophyll fluorescence, chloroplast ultrastructure, and changes in pigment-protein composition. Recorded Photosystem II and Photosystem I performance parameters indicate that highly dynamic structural and functional seasonal rearrangements of the photosynthetic apparatus occur. Although several mechanisms might contribute to ‘sustained quenching’ of winter/early spring pine needles, time-resolved fluorescence analysis shows that extreme down-regulation of photosystem II activity along with direct energy transfer from photosystem II to photosystem I plays a major role. This mechanism is enabled by extensive thylakoid destacking allowing for mixing of PSII with PSI complexes. These two linked phenomena play crucial roles in winter acclimation and protection.Graphical abstract
Annexin a2 as a target protein for chlorogenic acid in human lung cancer A549 cells
Authors: Wang Lei , Du Hongwu , Chen Peng 
Published: June 2020

AbstractChlorogenic acid, an important active component of coffee with anti-tumor activities, has been found for many years. However, the lack of understanding about its target proteins greatly limits the exploration of its anti-tumor molecular mechanism and clinical application. Here, in vitro and animal experiments showed that chlorogenic acid had a significant inhibitory effect on the proliferation of A549 cells. Using the spontaneous fluorescence characteristic of chlorogenic acid to screen the target proteins cleverly to avoid the problem of chemical modification increasing false positive, we identify and verify annexin A2 (ANXA2) as a covalent binding target of chlorogenic acid in A549 cells. Then, we discover that chlorogenic acid as an inhibitor of the binding of ANXA2 to p50 subunit inhibited the expression of downstream anti-apoptotic genes cIAP1 and cIAP2 of NF-κB signaling pathway in A549 cells in vitro and vivo. Moreover, we find chlorogenic acid hindered the binding of ANXA2 and actin maybe involved in the impediment of tumor cell cycle and migration. Thus, this work demonstrates that chlorogenic acid, as a binding ligand of ANXA2, decrease the expression of NF-κB downstream anti-apoptotic genes, inhibiting the proliferation of A549 cells in vivo and vitro.
Strain Level Microbial Detection and Quantification with Applications to Single Cell Metagenomics
Authors: Zhu Kaiyuan , Robinson Welles , Schäffer Alejandro A. , Xu Junyan , Ruppin Eytan , Ergun A. Funda , Ye Yuzhen , Sahinalp S. Cenk 
Published: June 2020

AbstractThe identification and quantification of microbial abundance at the species or strain level from sequencing data is crucial for our understanding of human health and disease. Existing approaches for microbial abundance estimation either use accurate but computationally expensive alignment-based approaches for species-level estimation or less accurate but computationally fast alignment-free approaches that fail to classify many reads accurately at the species or strain-level.Here we introduceCAMMiQ, a novel combinatorial solution to the microbial identification and abundance estimation problem, which performs better than the best used tools on simulated and real datasets with respect to the number of correctly classified reads (i.e., specificity) by an order of magnitude and resolves possible mixtures of similar genomes.As we demonstrate,CAMMiQcan better distinguish between single cells deliberately infected with distinctSalmonellastrains and sequenced using scRNA-seq reads than alternative approaches. We also demonstrate thatCAMMiQis also more accurate than the best used approaches on a variety of synthetic genomic read data involving some of the most challenging bacterial genomes derived from NCBI RefSeq database; it can distinguish not only distinct species but also closely related strains of bacteria.The key methodological innovation ofCAMMiQis its use of arbitrary length, doubly-unique substrings, i.e. substrings that appear in (exactly) two genomes in the input database, instead of fixed-length, unique substrings. To resolve the ambiguity in the genomic origin of doubly-unique substrings,CAMMiQemploys a combinatorial optimization formulation, which can be solved surprisingly quickly.CAMMiQ’s index consists of a sparsified subset of the shortest unique and doubly-unique substrings of each genome in the database, within a user specified length range and as such it is fairly compact. In short,CAMMiQoffers more accurate genomic identification and abundance estimation than the best used alternatives while using similar computational resources.Availabilityhttps://github.com/algo-cancer/CAMMiQ
Extensive individual differences of category information in ventral temporal cortex in the congenitally blind
Authors: Rosenke M. , Van den Hurk J. , Margalit E. , Op de Beeck H. P. , Grill-Spector K. , Weiner K. S. 
Published: June 2020

AbstractHuman ventral temporal cortex (VTC) is a cortical expanse that performs different functions and computations, but is especially critical for visual categorization. Nevertheless, accumulating evidence shows that category-selective regions persist in VTC in the absence of visual experience – for example, in congenitally blind (CB) participants. Despite this evidence, a large body of previous work comparing functional representations in VTC between sighted and CB participants performed univariate analyses at the group level, which assume a homogeneous population – an assumption that has not been formally tested until the present study. Specifically, using fMRI in CB and sighted participants (male and female), we empirically show that at the group level, distributed category representations in VTC are more reliable in the sighted (when viewing visual stimuli) compared to the CB (when hearing auditorily-substituted visual stimuli). Despite these group differences, there is extensive heterogeneity in VTC category representations in the CB to the point that VTC category representations in a subset of CB participants (some who were born without eyes, but not all) are more similar to sighted individuals compared to other CB participants. Together, our findings support a novel idea that driving factors contributing to the formation of VTC category representations in the blind are subject-specific, which complements factors that may generalize across group members. More broadly, the present findings caution conclusions of homogeneity across subjects within a group when performing group neuroimaging analyses without explicitly quantifying individual differences.
Generating a skin-based meta-model for compliant parts in composite material: numerical and experimental results
Authors: Polini Wilma , Corrado Andrea 
Published: June 2020

Purpose
The purpose of this paper is to present a skin-based approach able to generate the variability model for a component in composite material due to its manufacturing process. It generates a skin-based model of the manufactured part. The skin model discretizes the part surfaces by points to take into account the geometric deviations, those points are the nodes of finite element analysis used for tolerance analysis of compliant assemblies.

Design/methodology/approach
The paper presents a general and systematic simulation model for generating a variability meta-model for a component in composite material due to its manufacturing process. The model is constituted by three steps: definition and pre-processing of the nominal model, generation of the manufacturing process model and evaluation of the part variability.

Findings
The advantage of this approach is related to the fact that it is designed as a part of a digital process that establishes a continuous and unambiguous flow of variation information from the part design to manufacturing and assembly and that takes into account the manufacturing signature. This is its uniqueness compared to other simulation approaches focused only on manufacturing.

Research limitations/implications
Considering the variability around the nominal value of all the process parameters and parts with more complex geometries are not taken into account now, which will be modelled in practical applications.

Practical implications
To properly manage uncertainty since conceptual design of complex product, next generation geometry assurance requires simulation models to realistically consider process signatures due to the manufacturing process. This work focusses on this next generation tool for geometry assurance.

Originality/value
The literature is focused on metal sheets joined by welding or riveting. There are other materials widely used and typically compliant: the composite materials that typically used mechanical fixing elements (bolting, riveting) and structural adhesives to joint parts. No software tools exist in the literature to deal with uncertainty from manufacturing to assembly processes in products made by composite. This is the reason of the present work.
Personality traits, teamwork competencies and academic performance among first-year engineering students
Authors: Tang Kuok Ho Daniel 
Published: June 2020

PurposeIt is commonly believed that personality traits determine a person's ability to work in a team and academic performance. However, studies have shown inconsistent results with some personality traits better than the other in predicting students' performance in different academic majors. The purpose of this study is to examine the interrelation between personality traits, teamwork competencies and academic performance among first-year first semester engineering students in an Australian university located in the Sarawak state of Malaysia.Design/methodology/approachThe Individual and Team Performance (ITP) metrics were administered among 189 students to gauge their personality traits as well as self-rated and peer-rated teamwork competencies. The correlations between personality traits and teamwork competencies as well as correlations of both the variables to academic performance were subsequently analyzed.FindingsThis study shows no significant difference between the self-rated and peer-rated teamwork competencies. Adventurous trait appears to negatively correlate with teamwork competencies. This study also reveals teamwork competencies as better predictors of academic performance than personality traits. Commitment and focus show relatively larger effect on academic performance. It can be concluded that commitment is the most significant factor to excel in first-year engineering in the university. Therefore, interventions that promote commitment is crucial to academic performance of the first-year first semester engineering students.Practical implicationsThis study promulgates the development of team competencies which are more crucial to academic excellence than personalities. It is useful for the design of team learning activities which lead to the development of teamwork competencies while improving academic performance. It shows that team activities which reinforce commitment especially and focus secondarily, will have significant positive effect on academic performance of the first-year engineering students generally.Originality/valueWhile most studies in this area examine the correlation between personality traits and academic performance, this study is among the very few that looks into the aspect of teamwork competencies. This study also finds its value in its regional significance as such correlational studies are not prevalent in Malaysia.
Mobile landscapes and transport tourism: the visual experience of mobility during cruises and coach tours
Authors: Rhoden Steven , Kaaristo Maarja 
Published: June 2020

Purpose
This study aims to analyze the visual aspects of transport tourists’ experience of mobility focusing on British cruise and coach tourists’ international travel experiences.

Design/methodology/approach
The qualitative data was collected using semi-structured in-depth interviews with coach and cruise tourists and analyzed using thematic analysis.

Findings
The visual experience of mobility (demonstrated in the paper by the example of cruises and coach tours) is critical in the formation of transport tourism experiences. The mobile tourist landscapes emerge from the interplay of the subjective experiences of particular modes of mobility (vehicle or vessel) and routes, whereby the two key visual elements are the changing scenery and views of everyday local life as experienced whilst traveling.

Research limitations/implications
The present study focuses particularly on the visual elements of passive transport tourism experiences. It does not account for other tourist activities nor does it study the experiences associated with active transport tourism. Future research could perform a holistic analysis of tourists’ experiences of transport in all its forms.

Practical implications
The findings point to the centrality of the experience of mobility in transport tourism experience. The following two key aspects of the experience emerged: the importance of variation of the scenery that the tourist consumes during their tour and a desire to observe mundane, everyday life elements of the destination, which should be taken into account by the tour operators and service providers in the route design and marketing.

Originality/value
Coach and cruise tourism are rarely analyzed together; this study demonstrates considerable parallels between the two in considering them as transport tourism, a mode of recreational activity where mobility is the central part of the tourist experience and should, therefore, be considered a tourist attraction in and of itself.