bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adapting evidence-informed complex population health interventions for new contexts: a systematic review of guidance
Authors: Movsisyan A. , Arnold L. , Evans R. , Hallingberg B. , Moore G. , O’Cathain A. , Pfadenhauer L. M. , Segrott J. , Rehfuess E. 
Published: December 2019

Abstract
Background
Adapting interventions that have worked elsewhere can save resources associated with developing new interventions for each specific context. While a developing body of evidence shows benefits of adapted interventions compared with interventions transported without adaptation, there are also examples of interventions which have been extensively adapted, yet have not worked in the new context. Decisions on when, to what extent, and how to adapt interventions therefore are not straightforward, particularly when conceptualising intervention effects as contingent upon contextual interactions in complex systems. No guidance currently addresses these questions comprehensively. To inform development of an overarching guidance on adaptation of complex population health interventions, this systematic review synthesises the content of the existing guidance papers.

Methods
We searched for papers published between January 2000 and October 2018 in 7 bibliographic databases. We used citation tracking and contacted authors and experts to locate further papers. We double screened all the identified records. We extracted data into the following categories: descriptive information, key concepts and definitions, rationale for adaptation, aspects of adaptation, process of adaptation, evaluating and reporting adapted interventions. Data extraction was conducted independently by two reviewers, and retrieved data were synthesised thematically within pre-specified and emergent categories.

Results
We retrieved 6694 unique records. Thirty-eight papers were included in the review representing 35 sources of guidance. Most papers were developed in the USA in the context of implementing evidence-informed interventions among different population groups within the country, such as minority populations. We found much agreement on how the papers defined key concepts, aims, and procedures of adaptation, including involvement of key stakeholders, but also identified gaps in scope, conceptualisation, and operationalisation in several categories.

Conclusions
Our review found limitations that should be addressed in future guidance on adaptation. Specifically, future guidance needs to be reflective of adaptations in the context of transferring interventions across countries, including macro- (e.g. national-) level interventions, better theorise the role of intervention mechanisms and contextual interactions in the replicability of effects and accordingly conceptualise key concepts, such as fidelity to intervention functions, and finally, suggest evidence-informed strategies for adaptation re-evaluation and reporting.

Trial registration
PROSPERO 2018, CRD42018112714.
Evaluation of evening versus morning levothyroxine intake in elderly (MONIALE)
Authors: Giassi Karina , Piccoli Vanessa , da Costa Rodrigues Ticiana , Gorga Bandeira de Mello Renato 
Published: December 2019

AbstractBackgroundThe aging population is associated with increased multimorbidity and polypharmacy. Older adults are at a higher risk of adverse events and reduced therapeutic response. This phenomenon is partially explained by drug interactions and treatment adherence. Most randomized clinical trials have found no significant differences between morning and evening levothyroxine (LT4) administration in young adults, but there is little evidence regarding alternative LT4regimens in older populations. Thus, the MONIALE trial aims to test an alternative schedule for LT4administration in older adults.Methods/designThis randomized crossover clinical trial will include participants aged 60 years or older with primary hypothyroidism. The trial groups will consist of morning LT4intake (60 min before breakfast) or evening LT4intake (60 min after supper). The primary outcome will be variation in serum thyrotropin (TSH) levels after 24 weeks of the LT4protocol. The secondary outcomes will be the prevalence of drugs that potentially interact with LT4and hypothyroidism control according to interaction status. The sample size was calculated to detect a minimum mean difference of 1 mUI/L in serum TSH level between the groups with 80% power and a 5% probability of type I error, resulting in 91 patients per group. The project was approved by the Hospital de Clínicas de Porto Alegre Ethics Committee.DiscussionConsidering the aging population, the increased prevalence of multimorbidity and polypharmacy, as well as potential drug interactions and treatment adherence difficulties, an alternative LT4protocol could be useful for hypothyroidism treatment in the elderly. Prior studies comparing alternative LT4 administration protocols have mainly included young adult populations and have not addressed potential drug interactions.Trial registrationClinicalTrials.gov,NCT03614988. Registered 30 July 2018.
Genomics of circadian rhythms in health and disease
Authors: Rijo-Ferreira Filipa , Takahashi Joseph S. 
Published: December 2019

AbstractCircadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regulation of sleep, metabolism, and the immune system. Here, we review advances in understanding the genetic regulation of sleep through the circadian system, as well as the impact of dysregulated gene expression on metabolic function. We also review recent studies that have begun to unravel the circadian clock’s role in controlling the cardiovascular and nervous systems, gut microbiota, cancer, and aging. Such circadian control of these systems relies, in part, on transcriptional regulation, with recent evidence for genome-wide regulation of the clock through circadian chromosome organization. These novel insights into the genomic regulation of human physiology provide opportunities for the discovery of improved treatment strategies and new understanding of the biological underpinnings of human disease.
Prevalence and incidence of non-gout crystal arthropathy in southern Sweden
Authors: Hameed Mohaned , Turkiewicz Aleksandra , Englund Martin , Jacobsson Lennart , Kapetanovic Meliha C. 
Published: December 2019

Abstract
Objective
To estimate the prevalence and incidence of non-gout crystal arthropathy in relation to socioeconomic factors in southern Sweden.

Methods
All patients (age ≥ 18 years) with at least one visit to a physician with the diagnosis of interest in the Skåne region (population of 1.3 million) in 1998–2014 were identified. Non-gout crystal arthropathy (ICD-10 codes M11.0–M11.9) was subclassified in four different groups: calcium pyrophosphate crystal deposition related arthropathy (CPPD), unspecified non-gout arthropathies, chondrocalcinosis, and hydroxyapatite crystal deposition disease. The crude and age-adjusted point prevalence on December 31, 2014, and the cumulative incidence during 2014 were calculated for all non-gout crystal arthropathies, CPPD, and other unspecified non-gout arthropathies overall and in relation to occupation, income, and level of education.

Results
The crude 2014 point prevalence (95% CI) and 2014 cumulative incidence (95% CI) of all non-gout crystal arthropathies were 0.23% (0.23–0.24) and 21.5 (19–25) cases/100,000 persons. Mean age (range) among all prevalent cases in 2014 was 71 (20–102) years and 56% were males. The point prevalence and cumulative incidence of CPPD were 0.09% (0.08–0.09) and 8 (7–10)/100,000 persons, respectively. The corresponding data for unspecified non-gout crystal deposition disease was 0.16% (0.16–0.17) and 15.6 (13–18)/100,000 persons, respectively. The prevalence and incidence of CPPD and unspecified non-gout crystal arthropathies were slightly higher in men and increased with age irrespective of gender. Unspecified non-gout crystal arthropathy but not CPPD was less prevalent in persons with ≥ 15 years of education, whereas there were no clear associations with occupation and income.

Conclusion
The prevalence of all diagnosed non-gout crystal arthropathies was 0.23%, thus considerably less prevalent than gout in southern Sweden. CPPD and other unspecified non-gout crystal arthropathies are the predominant diagnoses, increasing with age and in men. With the exception for unspecified non-gout crystal arthropathies being inversely correlated to a higher level of education, no convincing association with the socioeconomic factors was found.
Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide
Authors: Zhang Jian-Xiang , Lai Yi-Hui , Mi Pan-Ying , Dai Xue-Ling , Zhang Ran , Zhang Zhan-Jun , Zhang Shu-Juan , Zhang Xi-Wen , Zhang Xi-Yan , Yang Bing-Yu , Cui Dong-Mei , Zhang Chen , Zhao Chang-Qi , Dou Fei 
Published: December 2019

Abstract
Background
Brain amyloid deposition is one of the main pathological characteristics of Alzheimer’s disease (AD). Soluble oligomers formed during the process that causes β-amyloid (Aβ) to aggregate into plaques are considered to have major neurotoxicity. Currently, drug development for the treatment of Alzheimer’s disease has encountered serious difficulties. Our newly proposed solution is to accelerate the aggregation of Aβ to reduce the amount of cytotoxic Aβ oligomers in brain tissue. This strategy differs from the existing strategy of reducing the total Aβ content and the number of amyloid plaques.

Method
In this study, we screened a small library and found that a flavonoid compound (ZGM1) promoted the aggregation of β-amyloid (Aβ). We further verified the binding of ZGM1 to Aβ42 using a microscale thermophoresis (MST) assay. Subsequently, we used dot blotting (DB), transmission electron microscopy (TEM), and thioflavin T fluorescence (ThT) measurements to study the aggregation of Aβ under the influence of ZGM1. By using cell experiments, we determined whether ZGM1 can inhibit the cytotoxicity of Aβ. Finally, we studied the protective effects of ZGM1 on cognitive function in APPswe/PS1 mice via behavioral experiments and measured the number of plaques in the mouse brain by thioflavin staining.

Results
ZGM1 can bind with Aβ directly and mediate a new Aβ assembly process to form reticular aggregates and reduce the amount of Aβ oligomers. Animal experiments showed that ZGM1 can significantly improve cognitive dysfunction and that Aβ plaque deposition in the brain tissue of mice in the drug-administered group was significantly increased.

Conclusion
Our research suggests that promoting Aβ aggregation is a promising treatment method for AD and deserves further investigation.
CSF synaptic protein concentrations are raised in those with atypical Alzheimer’s disease but not frontotemporal dementia
Authors: Clarke Mica T. M. , Brinkmalm Ann , Foiani Martha S. , Woollacott Ione O. C. , Heller Carolin , Heslegrave Amanda , Keshavan Ashvini , Fox Nick C. , Schott Jonathan M. , Warren Jason D. , Blennow Kaj , Zetterberg Henrik , Rohrer Jonathan D. 
Published: December 2019

Abstract
Background
Increased CSF levels of a number of synaptic markers have been reported in Alzheimer’s disease (AD), but little is known about their concentrations in frontotemporal dementia (FTD). We investigated this in three synaptic proteins, neurogranin, SNAP-25, and synaptotagmin-1.

Methods
CSF samples were analysed from 66 patients with a disorder in the FTD spectrum and 19 healthy controls. Patients were stratified by their tau to Aβ42 ratio: those with a ratio of > 1 considered as having likely AD pathology, i.e. an atypical form of AD (‘AD biomarker’ group [n = 18]), and < 1 as likely FTD pathology (‘FTD biomarker’ group [n = 48]). A subgroup analysis compared those in the FTD group with likely tau (n = 7) and TDP-43 (n = 18) pathology. Concentrations of neurogranin were measured using two different ELISAs (Ng22 and Ng36), and concentrations of two SNAP-25 fragments (SNAP-25tot and SNAP-25aa40) and synaptotagmin-1 were measured via mass spectrometry.

Results
The AD biomarker group had significantly higher concentrations of all synaptic proteins compared to controls except for synaptotagmin-1 where there was only a trend to increased levels—Ng22, AD mean 232.2 (standard deviation 138.9) pg/ml, controls 137.6 (95.9); Ng36, 225.5 (148.8) pg/ml, 130.0 (80.9); SNAP-25tot, 71.4 (27.9) pM, 53.5 (11.7); SNAP-25aa40, 14.0 (6.3), 7.9 (2.3) pM; and synaptotagmin-1, 287.7 (156.0) pM, 238.3 (71.4). All synaptic measures were significantly higher in the atypical AD group than the FTD biomarker group except for Ng36 where there was only a trend to increased levels—Ng22, 114.0 (117.5); Ng36, 171.1 (75.2); SNAP-25tot, 49.2 (16.7); SNAP-25aa40, 8.2 (3.4); and synaptotagmin-1, 197.1 (78.9). No markers were higher in the FTD biomarker group than controls. No significant differences were seen in the subgroup analysis, but there was a trend to increased levels in those with likely tau pathology.

Conclusions
No CSF synaptic proteins have been shown to be abnormal in those with likely FTD pathologically. Higher CSF synaptic protein concentrations of neurogranin, SNAP-25, and synaptotagmin-1 appear to be related to AD pathology.
Cladophora glomerata methanolic extract promotes chondrogenic gene expression and cartilage phenotype differentiation in equine adipose-derived mesenchymal stromal stem cells affected by metabolic syndrome
Authors: Bourebaba Lynda , Michalak Izabela , Baouche Meriem , Kucharczyk Katarzyna , Marycz Krzysztof 
Published: December 2019

Abstract
Background
Chondrogenesis represents a highly dynamic cellular process that leads to the establishment of various types of cartilage. However, when stress-related injuries occur, a rapid and efficient regeneration of the tissues is necessary to maintain cartilage integrity. Mesenchymal stem cells (MSCs) are known to exhibit high capacity for self-renewal and pluripotency effects, and thus play a pivotal role in the repair and regeneration of damaged cartilage. On the other hand, the influence of certain pathological conditions such as metabolic disorders on MSCs can seriously impair their regenerative properties and thus reduce their therapeutic potential.

Objectives
In this investigation, we attempted to improve and potentiate the in vitro chondrogenic ability of adipose-derived mesenchymal stromal stem cells (ASCs) isolated from horses suffering from metabolic syndrome.

Methods
Cultured cells in chondrogenic-inductive medium supplemented with Cladophora glomerata methanolic extract were experimented for expression of the main genes and microRNAs involved in the differentiation process using RT-PCR, for their morphological changes through confocal and scanning electron microscopy and for their physiological homeostasis.

Results
The different added concentrations of C. glomerata extract to the basic chondrogenic inductive culture medium promoted the proliferation of equine metabolic syndrome ASCs (ASCsEMS) and resulted in chondrogenic phenotype differentiation and higher mRNA expression of collagen type II, aggrecan, cartilage oligomeric matrix protein, and Sox9 among others. The results reveal an obvious inhibitory effect of hypertrophy and a strong repression of miR-145-5p, miR-146-3p, and miR-34a and miR-449a largely involved in cartilage degradation. Treated cells additionally exhibited significant reduced apoptosis and oxidative stress, as well as promoted viability and mitochondrial potentiation.

Conclusion
Chondrogenesis in EqASCsEMS was found to be prominent after chondrogenic induction in conditions containing C. glomerata extract, suggesting that the macroalgae could be considered for the enhancement of ASC cultures and their reparative properties.
LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis
Authors: Mao Qing , Liang Xiu-Lin , Zhang Chuan-Long , Pang Yi-Heng , Lu Yong-Xiang 
Published: December 2019

AbstractAimMyocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. This study aims to explore the effect and mechanism of lncRNA KLF3-AS1 in exosomes secreted by human mesenchymal stem cells (hMSCs) on pyroptosis of cardiomyocytes and MI.MethodsExosomes from hMSCs were isolated and identified. Exosomes from hMSCs with transfection of KLF3-AS1 for overexpression were injected into MI rat model or incubated with hypoxia cardiomyocytes. Effect of KLF3-AS1 on MI area, cell viability, apoptosis, and pyroptosis was determined. The relationship among miR-138-5p, KLF3-AS1, and Sirt1 was verified by dual-luciferase reporter assay. Normal cardiomyocytes were transfected with miR-138-5p inhibitor or sh-Sirt1 to clarify whether alteration of miR-138-5p or sh-Sirt1 can regulate the effect of KLF3-AS1 on cardiomyocytes.ResultsExosomes from hMSCs were successfully extracted. Transfection of KLF3-AS1 exosome in rats and incubation with KLF3-AS1 exosome in hypoxia cardiomyocytes both verified that overexpression of KLF3-AS1 in exosomes leads to reduced MI area, decreased cell apoptosis and pyroptosis, and attenuated MI progression. KLF3-AS1 can sponge miR-138-5p to regulate Sirt1 expression. miR-138-5p inhibitor transfection and KLF3-AS1 exosome incubation contribute to attenuated pyroptosis and MI both in vivo and in vitro, while transfection of sh-Sirt1 could reverse the protective effect of exosomal KLF3-AS1 on hypoxia cardiomyocytes.ConclusionLncRNA KLF3-AS1 in exosomes secreted from hMSCs by acting as a ceRNA to sponge miR-138-5p can regulate Sirt1 so as to inhibit cell pyroptosis and attenuate MI progression.
Effects of cobalt-histidine absorbent on aerobic denitrification by Paracoccus versutus LYM
Authors: Sun Chaoyue , Zhang Yu , Qu Zhenping , Zhou Jiti 
Published: December 2019

AbstractTo overcome the problem that ferrous complexes are easily oxidized by O2and then lose NO binding ability in the chemical absorption-biological reduction (CABR) process, cobalt(II)-histidine [Co(II)His] was proposed as an alternative. To evaluate the applicability of Co(II)His, the effects of CoHis absorbent on the aerobic denitrification byParacoccus versutusLYM were investigated. Results indicated that His significantly promoted nitrite reduction. The inhibition effects of CoHis absorbent could be substantially alleviated by increasing the initial His/Co2+to 4 or higher. CoHis with concentrations of 4, 8, 12, 16 and 20 mM presented no distinct effect on nitrite reduction, but slightly inhibited the reduction of nitrate, resulting in longer lag of nitrate reduction, and obviously promoted the growth of strain LYM. In the presence of 5, 10, 15 and 20 mM CoHis absorbent, the main denitrification product was N2(not less than 95.0%). This study is of significance in verifying the applicability of Co(II)His in the CABR process, and provides a referable CoHis absorbent concentration as 20 mM with an initial His/Co2+of 4 for the future experiments.
Research on Wi-Fi indoor positioning in a smart exhibition hall based on received signal strength indication
Authors: Yang Qing , Zheng Shijue , Liu Ming , Zhang Yawen 
Published: December 2019

AbstractTo improve the management of science and technology museums, this paper conducts an in-depth study on Wi-Fi (wireless fidelity) indoor positioning based on mobile terminals and applies this technology to the indoor positioning of a science and technology museum. The location fingerprint algorithm is used to study the offline acquisition and online positioning stages. The positioning flow of the location fingerprint algorithm is discussed, and the improvement of the location fingerprint algorithm is emphasized. The raw data of the RSSI (received signal strength indication) is preprocessed, which makes the location fingerprint data more effective and reliable, thus improving the positioning accuracy. Three different improvement strategies are proposed for the nearest neighbor classification algorithm: a balanced joint metric based on distance weighting and a compromise between the two. Then, in the experimental simulation, the positioning results and errors of the traditional KNN (k-nearest neighbor) algorithm and three improvement strategy algorithms are analyzed separately, and the effectiveness of the three improved strategy algorithms is verified by experiments.
Resource allocation for secure Gaussian parallel relay channels with finite-length coding and discrete constellations
Authors: Senigagliesi Linda , Baldi Marco , Tomasin Stefano 
Published: December 2019

AbstractWe investigate the transmission of a secret message from Alice to Bob in the presence of an eavesdropper (Eve) and many of decode-and-forward relay nodes. Each link comprises a set of parallel channels, modeling for example an orthogonal frequency division multiplexing transmission. We consider the impact of efficient implementations, including discrete constellations and finite-length coding, defining an achievable secrecy rate under a constraint on the equivocation rate at Eve. Then, we propose a power and channel allocation algorithm that maximizes the achievable secrecy rate by resorting to two coupled Gale-Shapley algorithms for stable matching problem. We consider the scenarios of both full and partial channel state information at Alice. In the latter case, we only guarantee anoutagesecrecy rate, i.e., the rate of a message that remains secret with a given probability. Numerical results are provided for Rayleigh fading channels in terms of average outage secrecy rate, showing that practical schemes achieve a performance quite close to that of ideal ones.
A novel approach to workload prediction using attention-based LSTM encoder-decoder network in cloud environment
Authors: Zhu Yonghua , Zhang Weilin , Chen Yihai , Gao Honghao 
Published: December 2019

AbstractServer workload in the form of cloud-end clusters is a key factor in server maintenance and task scheduling. How to balance and optimize hardware resources and computation resources should thus receive more attention. However, we have observed that the disordered execution of running application and batching seriously cuts down the efficiency of the server. To improve the workload prediction accuracy, this paper proposes an approach using the long short-term memory (LSTM) encoder-decoder network with attention mechanism. First, the approach extracts the sequential and contextual features of the historical workload data through the encoder network. Second, the model integrates the attention mechanism into the decoder network, through which the prediction for batch workloads can be carried out. Third, experiments carried out on Alibaba and Dinda workload traces dataset demonstrate that our method achieves state-of-the-art performance in mixed workload prediction in cloud computing environment. Furthermore, we also propose a scroll prediction method, which splits a long prediction sequence into several small sequences to monitor and control prediction accuracy. This work helps to dynamically guide the configuration for workload balancing.