bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of solid malignancies in bullous pemphigoid: A large‐scale population‐based cohort study
Authors: Kridin Khalaf , Hammers Christoph M. , Ludwig Ralf J. , Cohen Arnon D. 
Published: December 2020

AbstractThe association of bullous pemphigoid (BP) with solid malignancies (SM) is a matter of controversy, as previous studies produced inconclusive findings. The aim of this study was to assess the risk of SM among patients with BP and to evaluate whether a history of SM predisposes individuals to develop subsequent BP. A population‐based cohort study was performed comparing BP patients (n = 3924) with age‐, sex‐ and race‐matched control subjects (n = 19 280) with regard to incident cases of SM. Adjusted hazard ratios (HR) and adjusted odds ratios (OR) were estimated by Cox regression and logistic regression, respectively. The incidence of SM was 13.4 (95% confidence interval [CI], 11.6–15.3) and 14.3 (95% CI, 13.5–15.1) per 1000 person‐years among patients with BP and controls, respectively. BP was not associated with an increased risk of SM (adjusted HR, 0.90; 95% CI, 0.77–1.05). Additionally, a history of SM was not related to the risk of subsequent BP (adjusted OR, 1.00; 95% CI, 0.90–1.10). In a stratified analysis, patients with BP had an increased risk of uterine cancer (adjusted HR, 2.56; 95% CI, 1.39–4.72) unlike the 18 remaining analyzed types of SM. Relative to BP patients without SM, those with BP and SM were older, had a male predominance, a higher prevalence of smoking, a higher burden of comorbidities and comparable survival rates. Although patients with BP do not experience an overall increased risk of developing SM, they are more likely to have uterine cancer. Our findings argue against routine extended cancer screening for patients with incident BP, but raise the awareness of uterine cancer among females with BP.
Quantifying crop pollinator dependence and its heterogeneity using multi‐level meta‐analysis
Authors: Bishop Jacob , Nakagawa Shinichi 
Published: December 2020

Abstract

Biotic pollination can benefit crop production, but its effects are highly variable. To maximise benefits from this ecosystem service, we need a greater understanding of the factors that cause variation so that ecological intensification can be more effectively applied.

We focus on understanding the benefits of pollination to faba bean Vicia faba. We use a literature review followed by multi‐level meta‐analysis to estimate overall benefits of pollination to faba bean yield and to quantify variation (heterogeneity) in these benefits associated with different contextual factors (e.g. plant genotype, growing environment).

Our overall estimate of pollination benefit to faba bean yield, expressed as the percentage yield reduction without pollination, is 32.9% (confidence interval: 21%–43%). Based on the prediction intervals, which include the heterogeneity in pollination benefit, there is an 80% chance that pollination will increase yield of a faba bean crop.

Half of all heterogeneity in pollination dependence was due to differences between plant genotypes. The number of beans per plant showed similar pollination dependence to yield mass per plant while pod number and number of beans per pod underestimated yield benefits. There was weak evidence to suggest pollination benefits vary between pollinator species, with honeybees showing a smaller yield increase.

Differences in the experimental method used to assess pollination benefit did not significantly affect the estimate, including the growing environment, measurement scale, or whether the effects of experimental pollinator enclosures were controlled. This suggests that simplified experimental studies comparing yield of open‐pollinated and enclosed plants can provide reliable insights into pollination benefits across a large range of plant genotypes and landscapes.

Synthesis and application. We found high variability in pollination benefits both between and within publications in our meta‐analysis. Plant genotype, how yield was measured, and pollinator species affected the level of pollination benefit. Despite variability in pollination benefits due to various contextual factors (both inside and outside of grower control), there is a high likelihood that biotic pollination will increase faba bean yield. Our findings support ecological intensification and specifically the management of pollinators to maximise pollination benefits to faba bean production.
Benchmarking of single‐virus genomics: a new tool for uncovering the virosphere
Authors: Garcia‐Heredia Inmaculada , Bhattacharjee Ananda S. , Fornas Oscar , Gomez Monica L. , Martínez Joaquín M. , Martinez‐Garcia Manuel 
Published: December 2020

SummaryMetagenomics and single‐cell genomics have enabled the discovery of relevant uncultured microbes. Recently, single‐virus genomics (SVG), although still in an incipient stage, has opened new avenues in viral ecology by allowing the sequencing of one single virus at a time. The investigation of methodological alternatives and optimization of existing procedures for SVG is paramount to deliver high‐quality genomic data. We report a sequencing dataset of viral single‐amplified genomes (vSAGs) from cultured and uncultured viruses obtained by applying different conditions in each SVG step, from viral preservation and novel whole‐genome amplification (WGA) to sequencing platforms and genome assembly. Sequencing data showed that cryopreservation and mild fixation were compatible with WGA, although fresh samples delivered better genome quality data. The novel TruPrime WGA, based on primase‐polymerase features, and WGA‐X employing a thermostable phi29 polymerase, were proven to be with sufficient sensitivity in SVG. The Oxford Nanopore (ON) sequencing platform did not provide a significant improvement of vSAG assembly compared to Illumina alone. Finally, the SPAdes assembler performed the best. Overall, our results represent a valuable genomic dataset that will help to standardized and advance new tools in viral ecology.
To Advocate or Not to Advocate: Determinants and Financial Consequences of CEO Activism
Authors: Bedendo Mascia , Siming Linus 
Published: December 2020

AbstractChief executive officers (CEOs) who engage in activism take public stands on issues that are largely unrelated to the core business of their firms. This study assesses the impact of CEO activism on shareholder value and investigates potential drivers behind the decision to advocate. We conduct an event study centred on a particular episode of CEO activism: the resignation of a group of business leaders from their roles as advisors to President Trump. We choose this setting since activism is likely to have a stronger impact when a CEO is politically connected. However, by engaging in advocacy, a CEO risks severing the very same political links that underlie the strength of the message. We find that shareholders react negatively to the decision to quit a presidential advisory council, which is consistent with a fear of weakening their firm's political influence. The decision to publicly advocate seems to be driven more by a CEO's personal political ideology than by a company's general involvement in corporate social responsibility. We also observe that managers are more likely to take a stand when they are protected by their firm's corporate governance rules. This study provides empirical evidence of the risks associated with CEO activism.
TOWARDS A POSTCOLONIAL PERSPECTIVE ON CLIMATE URBANISM
Authors: Robin Enora , Broto Vanesa Castán 
Published: December 2020

AbstractThe growing interest in urban areas as sites for climate action has led to new ways of conceiving and planning the urban. As climate actions reshape existing understandings of what cities are or ought to be, they constitute new modalities of what recent scholarship has referred to as ‘climate urbanism’. This research has framed climate urbanism as a climate‐inflected iteration of neoliberal urban development, geared towards the mobilization of ‘green’ private capital for large‐scale infrastructural projects, focused on carbon metrics, and conducive to population displacement through eco‐gentrification. In this intervention, we commend these efforts to deliver a critical perspective on how climate change gives rise to forms of urbanism that reproduce urban injustices without addressing the root causes of the climate crisis. However, we warn against two biases in recent scholarship, namely an emphasis on technological solutions and an overreliance on familiar contexts of climate action. The literature on climate urbanism does not yet reflect the diversity of urban responses emerging under the broad umbrella of urban climate action. Adopting a post‐colonial perspective on climate urbanism, we call for a greater engagement with the heterogeneous character of climate‐changed urban futures.
Hydrogen cyanide and carboxyhemoglobin assessment in an open space fire‐related fatality
Authors: Tabian Daniel , Bulgaru Iliescu Diana , Iov Tatiana , Barna Barabas , Toma Sebastian Ionut , Drochioiu Gabi 
Published: December 2020

AbstractHydrogen cyanide (HCN) can be a major contributory factor in death from fire‐related inhalation injury. Although carbon monoxide (CO) is considered the lethal agent of smoke in fires, its liability as a cause of death is sometimes debatable. The purpose of this report is to present the case of an 80‐year‐old man with locomotor disabilities who died due to an open space fire of vegetation debris and household waste in his yard. We evaluated here the concentrations of HCN and carboxyhemoglobin (COHb) and their contribution to the mechanism of death. In addition, the risk factors and the contributing effect of the factors that compose the complex toxic environment that develops in fires were discussed. COHb was determined by spectrophotometry as recommended by Katsumata et al. in 1982. HCN was determined with ninhydrin in postmortem blood samples after removal with 20% phosphoric acid and capture in a potassium carbonate solution. A toxic concentration of 1.3 μg ml−1 HCN and a lethal COHb level of 73.7% were determined in the blood samples. Although death was mainly attributed to CO poisoning and extremely severe burns in this open space burning case, the additive effect of HCN in the mechanism of death was also highlighted. The results suggested the possibility that the man's clothing may have played an important role in the production of HCN in this open space fire, as well as other types of garbage that were burned.
One‐pot synthesis of 6‐aminohexanoic acid from cyclohexane using mixed‐species cultures
Authors: Bretschneider Lisa , Wegner Martin , Bühler Katja , Bühler Bruno , Karande Rohan 
Published: December 2020

Summary6‐Aminohexanoic acid (6AHA) is a vital polymer building block for Nylon 6 production and an FDA‐approved orphan drug. However, its production from cyclohexane is associated with several challenges, including low conversion and yield, and severe environmental issues. We aimed at overcoming these challenges by developing a bioprocess for 6AHA synthesis. A mixed‐species approach turned out to be most promising. Thereby, Pseudomonas taiwanensis VLB120 strains harbouring an upstream cascade converting cyclohexane to either є‐caprolactone (є‐CL) or 6‐hydroxyhexanoic acid (6HA) were combined with Escherichia coli JM101 strains containing the corresponding downstream cascade for the further conversion to 6AHA. ε‐CL was found to be a better ‘shuttle molecule’ than 6HA enabling higher 6AHA formation rates and yields. Mixed‐species reaction performance with 4 g l‐1 biomass, 10 mM cyclohexane, and an air‐to‐aqueous phase ratio of 23 combined with a repetitive oxygen feeding strategy led to complete substrate conversion with 86% 6AHA yield and an initial specific 6AHA formation rate of 7.7 ± 0.1 U gCDW‐1. The same cascade enabled 49% 7‐aminoheptanoic acid yield from cycloheptane. This combination of rationally engineered strains allowed direct 6AHA production from cyclohexane in one pot with high conversion and yield under environmentally benign conditions.
A Landscape Assessment and Associated Dataset of Stream Confluences for the Conterminous U.S.
Authors: Ebert Donald , Wickham James , Neale Anne , Mehaffey Megan 
Published: December 2020

AbstractStream confluences are important components of fluvial networks. Hydraulic forces meeting at stream confluences often produce changes in streambed morphology and sediment distribution. These changes often increase habitat heterogeneity relative to upstream and downstream locations, which have led some to identify them as biological hotspots. Despite their potential ecological importance, there are relatively few empirical studies documenting ecological patterns upstream and downstream of confluences. We have produced a publicly available dataset of stream confluences and associated watershed attributes for the conterminous United States. The dataset includes 1,085,629 stream confluences and 383 attributes for each confluence organized into 15 dataset tables for both tributary and mainstem upstream catchments and watersheds. Themes in the dataset include hydrology (e.g., stream order), land cover, land cover change, geology (e.g., calcium content of underlying lithosphere), physical condition (e.g., precipitation), measures of ecological integrity, and stressors (e.g., impaired streams). Additionally, we used measures of ecological integrity to assess the condition of the stream confluences. Aside from a generally positive east‐to‐west gradient in ecological condition, we found that approximately one‐third of the confluences had markedly contrasting ecological conditions between mainstem and tributary, catchment and watershed, or both. The dataset should support many, multifaceted studies of stream confluence ecology.
Conserved bacterial genomes from two geographically isolated peritidal stromatolite formations shed light on potential functional guilds
Authors: Waterworth Samantha C. , Isemonger Eric W. , Rees Evan R. , Dorrington Rosemary A. , Kwan Jason C. 
Published: December 2020

SummaryStromatolites are complex microbial mats that form lithified layers. Fossilized stromatolites are the oldest evidence of cellular life on Earth, dating back over 3.4 billion years. Modern stromatolites are relatively rare but may provide clues about the function and evolution of their ancient counterparts. In this study, we focus on peritidal stromatolites occurring at Cape Recife and Schoenmakerskop on the southeastern South African coastline, the former being morphologically and structurally similar to fossilized phosphatic stromatolites formations. Using assembled shotgun metagenomic analysis, we obtained 183 genomic bins, of which the most dominant taxa were from the Cyanobacteria phylum. We identified functional gene sets in genomic bins conserved across two geographically isolated stromatolite formations, which included relatively high copy numbers of genes involved in the reduction of nitrates and phosphatic compounds. Additionally, we found little evidence of Archaeal species in these stromatolites, suggesting that they may not play an important role in peritidal stromatolite formations, as proposed for hypersaline formations.
PROSPECT guideline for elective caesarean section: updated systematic review and procedure‐specific postoperative pain management recommendations
Authors: Roofthooft E. , Joshi G. P. , Rawal N. , Van de Velde M. ,   the PROSPECT Working Group* of the European Society of Regional Anaesthesia and Pain Therapy and supported by the Obstetric Anaesthetists’ Association
Published: December 2020

SummaryCaesarean section is associated with moderate‐to‐severe postoperative pain, which can influence postoperative recovery and patient satisfaction as well as breastfeeding success and mother‐child bonding. The aim of this systematic review was to update the available literature and develop recommendations for optimal pain management after elective caesarean section under neuraxial anaesthesia. A systematic review utilising procedure‐specific postoperative pain management (PROSPECT) methodology was undertaken. Randomised controlled trials published in the English language between 1 May 2014 and 22 October 2020 evaluating the effects of analgesic, anaesthetic and surgical interventions were retrieved from MEDLINE, Embase and Cochrane databases. Studies evaluating pain management for emergency or unplanned operative deliveries or caesarean section performed under general anaesthesia were excluded. A total of 145 studies met the inclusion criteria. For patients undergoing elective caesarean section performed under neuraxial anaesthesia, recommendations include intrathecal morphine 50–100 µg or diamorphine 300 µg administered pre‐operatively; paracetamol; non‐steroidal anti‐inflammatory drugs; and intravenous dexamethasone administered after delivery. If intrathecal opioid was not administered, single‐injection local anaesthetic wound infiltration; continuous wound local anaesthetic infusion; and/or fascial plane blocks such as transversus abdominis plane or quadratus lumborum blocks are recommended. The postoperative regimen should include regular paracetamol and non‐steroidal anti‐inflammatory drugs with opioids used for rescue. The surgical technique should include a Joel‐Cohen incision; non‐closure of the peritoneum; and abdominal binders. Transcutaneous electrical nerve stimulation could be used as analgesic adjunct. Some of the interventions, although effective, carry risks, and consequentially were omitted from the recommendations. Some interventions were not recommended due to insufficient, inconsistent or lack of evidence. Of note, these recommendations may not be applicable to unplanned deliveries or caesarean section performed under general anaesthesia.
Clinical evidence, diagnostic approach and challenging therapeutic modalities for malignant melanoma of the anorectum
Authors: Mastoraki Aikaterini , Schizas Dimitrios , Ntella Vasiliki , Roka Anastasia , Vailas Michail , Papanikolaou Ioannis S. , Vassiliu Pantelis , Papaconstantinou Ioannis 
Published: December 2020

AbstractPrimary anorectal malignant melanoma (ARMM) is a rare, aggressive tumour that accounts for approximately 1.2% of all melanomas. This rare entity represents less than 5% of anorectal malignant tumours and 0.05–1% of all malignant colorectal neoplasms. The incidence increases with age while there is a higher prevalence in Caucasians. ARMM is often asymptomatic or presents with no disease‐specific evidence so that it can mimic other rectal disorders, malignant or benign. Colonoscopy is obligatory as a diagnosing mean for ARMM. Furthermore, endoscopic ultrasonography, computed tomography and magnetic resonance imaging can be utilized for the evaluation of tumour infiltration and lymph node metastases. Moreover, diagnostic establishment of ARMM requires an undeniable demonstration of essential melanocytic features in histology and immunohistochemistry. Even though the standard of treatment remains surgical resection, the choice between wide local excision and abdomino‐perineal resection is still controversial. Recently, there have been recommendations regarding new techniques which could be utilized for the surgical treatment of ARMM. Newer treatments that have been proposed such as immune‐checkpoint inhibitors and targeted therapies need further validation. A multicenter study would allow clarification of the most appropriate therapeutic strategy for this uncommon nosological entity.
Traumatic duodenal injuries in children: a single‐centre study
Authors: Goh Barnabas , Soundappan Soundappan S. V. 
Published: December 2020

AbstractBackgroundTraumatic duodenal injuries in children are rare, and few studies have documented duodenal injuries in children, especially in Australasia. This study assessed the mechanism, investigations, management and outcomes of children (aged <16 years) with duodenal injuries.MethodsRetrospective review was conducted over a 16‐year period from a single paediatric trauma centre.ResultsSixteen cases of duodenal injuries were identified: 15 cases of blunt duodenal injury and only one case of penetrating injury. Motor vehicular accidents were the most common cause of injury, followed by auto‐pedestrian injuries and handlebar injuries. Only grade I and II injuries were identified. Computed tomography aided diagnosis in all cases of blunt duodenal injuries, especially given the variable nature of symptoms. Eight patients underwent laparotomy, of whom five required duodenal repair. Three patients underwent primary repair with omental patch, one patient underwent primary repair with gastrostomy and one patient underwent two‐layered repair with t‐tube duodenostomy. There were no delays in operative management within 24 h and no complications identified.ConclusionIn comparison to other paediatric trauma centres worldwide, the majority of duodenal injuries were low grade and attributed to blunt trauma. Computed tomography aided diagnosis in all cases of blunt duodenal injury. Primary repair of duodenal injuries was possible in the majority of cases requiring operative repair.
A novel tool to assess the quality of RWE to guide the management of retinal disease
Authors: Finger Robert P. , Daien Vincent , Talks James S. , Mitchell Paul , Wong Tien Y. , Sakamoto Taiji , Eldem Bora M. , Lövestam‐Adrian Monica , Korobelnik Jean‐François 
Published: December 2020

AbstractDespite the growing importance of real‐world evidence (RWE) for guiding clinical decisions in retinal disease, there is currently no widely used guidance available for assessing the quality and relevance of RWE studies in ophthalmology. This paper summarizes the development of a user‐friendly tool that facilitates assessment of the quality of available RWE for neovascular age‐related macular degeneration (nAMD), diabetic macular oedema (DME) and retinal vein occlusion (RVO). A literature search was conducted to identify tools developed to assess the quality of RWE, in order to identify the most appropriate framework on which to base this tool. The Good Research for Comparative Effectiveness (GRACE) guidelines was chosen for this purpose as it is designed to assess the quality of observational studies and has been extensively validated, including demonstration of strong sensitivity and specificity. The GRACE guidelines were adapted to develop a straightforward tabular tool that allows simple assessment and comparison of the quality of published evidence in retinal disease for researchers and physicians alike, and includes guidance on treatment details, outcome measures, study population, and controlling for bias. The newly developed tool provides a simple method to support assessment of the strength of evidence and certainty of conclusions drawn from RWE in retinal disease, to ensure clinical decision‐making is influenced by the highest quality evidence.