bluuebunny/crossref_metadata_2025_split huggingface dataset:
98-LB: Individual Glycemic Response to Ultra-Rapid vs. Rapid Insulin Delivered Automatically with the Ilet Bionic Pancreas System
Authors: SHERWOOD JORDAN , ZHENG HUI , BALLIRO COURTNEY A. , EKHLASPOUR LAYA , BUCKINGHAM BRUCE A. , EL-KHATIB FIRAS , DAMIANO EDWARD , RUSSELL STEVEN J. 
Published: June 2020

In a recent multicenter, random-order, home-use trial (NCT03565666), we examined automated glycemic control with the insulin-only configuration of the bionic pancreas (BP) using subjects’ typical insulin analogue, BP-T (aspart, n=7 or lispro, n=27), versus using the ultra-rapid faster aspart, BP-F. The dosing algorithm was identical in both arms and used the same setting for insulin absorption speed (tmax=65 minutes). The mean CGM glucose (CGMG) was similar between the BP-F and BP-T arms (154±11 vs. 155±13 mg/dl), as was the median percent time &lt;54 mg/(0.6% [0.2-1.1%] vs. 0.6% [0-1.3%]). We used an autoregressive time series model to determine statistical significance for differences between the BP-F and BP-T arms in individual subjects. Nine subjects had a significantly lower mean CGMG during the BP-F arm (by 13±8 mg/dl), 10 subjects had a significantly higher mean CGMG during the BP-F arm (by 10±5 mg/dl), and 15 subjects had no significant difference between arms (nominal difference 2±2 mg/dl). One subject with a significantly lower mean CGMG in the BP-F arm also had a significant decrease of 1.4% in time &lt;54 mg/dl (~20 minutes per day), one subject with no difference in mean CGMG between arms had a significant increase of 1.4% in time &lt;54 mg/dl in the BP-F arm, and 32 subjects had no significant differences in time &lt;54 mg/dl between arms. There was a statistically significant reduction in mean CGMG from the use of Fiasp without adjustment of the setting for insulin absorption speed for some subjects, but a similar number saw a significant increase in mean CGMG, while there was no difference for the remainder of subjects. Other studies are under way to test whether adjusting the BP insulin delivery algorithm tmax setting will allow more subjects to benefit from the use of faster aspart in the iLet.

Disclosure
J. Sherwood: None. H. Zheng: None. C.A. Balliro: None. L. Ekhlaspour: None. B.A. Buckingham: Advisory Panel; Self; ConvaTec Inc., Medtronic. Research Support; Self; Beta Bionics, Inc., Dexcom, Inc., Insulet Corporation, Medtronic, Tandem Diabetes Care. F. El-Khatib: Other Relationship; Self; Beta Bionics, Inc. E. Damiano: Board Member; Self; Beta Bionics, Inc. Employee; Self; Beta Bionics, Inc. Stock/Shareholder; Self; Beta Bionics, Inc. Stock/Shareholder; Spouse/Partner; Beta Bionics, Inc. S.J. Russell: Consultant; Self; Beta Bionics, Inc., ConvaTec Inc., Novo Nordisk A/S, Senseonics. Research Support; Self; Beta Bionics, Inc., Novo Nordisk A/S, Zealand Pharma A/S. Stock/Shareholder; Self; Companion Medical. Other Relationship; Self; Ascensia Diabetes Care, Roche Diabetes Care.

Funding
National Institutes of Health
98-OR: Placental DNA Methylation Changes Associated with Birthweight and Overlaps with Adult Type 2 Diabetes
Authors: TEKOLA-AYELE FASIL , WORKALEMAHU TSEGASELASSIE , ZENG XUEHUO 
Published: June 2020

Background: There is cumulating evidence for associations between birthweight-lowering genetic factors and increased risk of type 2 diabetes (T2D). Given the crucial role of the placenta in supporting fetal growth, epigenetic mechanisms in placenta may lend insights into prevention of T2D in early life. We investigated epigenetic changes in placenta associated with birthweight and those that overlap with T2D risk.
Methods: DNA methylation was measured using Illumina’s Infinium Human Methylation450 Beadchip in placenta samples obtained from race/ethnic-diverse pregnant women who participated in the NICHD Fetal Growth Studies (n=301). Associations between DNA methylation and birthweight were tested using linear regression models. Next, we examined whether DNA methylation at loci previously implicated in adult T2D were associated with birthweight in placenta. The relationship between DNA methylation and gene expression was tested in 75 placenta samples profiled for both DNA methylation and gene expression. Statistical tests were considered significant at a false discovery rate &lt; 0.05.
Results: Placenta methylation at 15 cytosine-phosphate-guanine (CpG) sites was significantly associated with birthweight, of which methylation at UBXN11, LBX2, CNIH2, and PDE9A was significantly associated with expression of nearby genes. At six CpG sites (MGRN1, AMIGO2, CHD3 and three intergenic regions) known in previous studies to be associated with adult T2D, we found significant associations between DNA methylation in placenta and birthweight. For all the six CpG sites, the methylation changes related to increased risk of T2D were associated with lower birthweight.
Conclusions: We found novel placental DNA methylation signatures associated with lower birthweight and higher risk of adult T2D. Our findings provide the first evidence to suggest that epigenetic changes in the placenta may be one potential mechanism that explains the link between early growth and later life T2D.

Disclosure
F. Tekola-Ayele: None. T. Workalemahu: None. X. Zeng: None.

Funding
Eunice Kennedy Shriver National Institute of Child Health and Human Development
980-P: Anticipating Regular Physical Activity with a New Artificial Pancreas System: A Pilot Study
Authors: GARCIA-TIRADO JOSE , BROWN SUE A. , LAICHUTHAI NITCHAKARN , MYERS HELEN E. , BRETON MARC D. 
Published: June 2020

Glycemic control during and after exercise is challenging. APs reduce %&lt;70 and TIR, but do not eliminate exercise-induced hypoglycemia. Recent work has shown that insulin reduction 90min prior to exercise may be optimal. We present the initial testing of an exercise-informed AP, able to anticipate regular exercise by up to 2h without user input. Eighteen adults with T1D were enrolled in a randomized crossover trial: 4-weeks data collection (DC: SAP+step counter) followed by two 32h supervised hotel stays (SH). During DC, participants were asked to exercise 4 times/week for &gt;30min, between 4-7pm. During SH, participants used either a naïve AP (CTL) or exercise informed AP (EX) and participated in 45min of moderate exercise at 17:30 on day 1. Fifteen subjects completed the study, age 42.2±13.6, HbA1c 6.61±1.02, with no system related AEs. During exercise, EX and CTL had similar TIR 88.2 vs. 85.2%, with a tendency to less time &lt;80mgdL, 14.8 vs. 8.2%, following a reduction of insulin from 2.4 to 1.8 U over the preceding 2h. Post exercise EX and CTL had similar TIR (87.2 vs. 85.5%) but EX had less %&lt;70 1.1% vs. 8.9% p=0.04,overnight control was excellent in both case TIR: 98.1 vs. 99.4%; %&lt;70: 0.1 vs. 0.6%. During the sedentary late afternoon (5-7pm day 2) there was no difference in TIR: 89.6 vs. 86.0%. APs can learn from prior exercise behaviors and anticipate them, potentially leading to reduced glycemic risk, and a more automated system.

Disclosure
J. Garcia-Tirado: None. S.A. Brown: Research Support; Self; Dexcom, Inc., Insulet Corporation, Roche Diabetes Care, Tandem Diabetes Care, Tolerion, Inc. N. Laichuthai: None. H.E. Myers: None. M.D. Breton: Research Support; Self; Dexcom, Inc., Novo Nordisk A/S, Sanofi, Tandem Diabetes Care. Speaker’s Bureau; Self; Dexcom, Inc., Tandem Diabetes Care.

Funding
National Institutes of Health (DP3DK106826)
987-P: Efficacy and Safety Comparison between U-100 Human Regular Insulin and Rapid-Acting Insulin When Delivered by V-Go Wearable Insulin Delivery in an Older Type 2 Diabetes Population
Authors: SUTTON DAVID R. , MORA PABLO F. , GORE ASHWINI , BALIGA BANTWAL , GOLDFADEN REBECCA F. , NIKKEL CARLA C. , SINK JOHN H. , ADAMS-HUET BEVERLEY A. 
Published: June 2020

The price of insulin has risen substantially and been associated with higher out-of-pocket costs and quicker entry into the Medicare coverage gap, negatively impacting diabetes care in older adults. Evidence from a large health plan supports Human Regular Insulin (HRI), when used effectively, as a viable treatment option for many patients with T2D including older adults. In a recently completed multi-site, 14-week randomized, parallel, study (N=113), non-inferiority was demonstrated when switching from Rapid Acting Insulin (RAI) to HRI delivered by V-Go with a mean change ETD in A1C of -0.22% (95% CI -0.67, 0.22); p=0.007 favoring HRI and no statistical differences in insulin dose, weight or hypoglycemia. We explored these outcomes using mixed-effects models in a post-hoc analysis in pts ≥ 65 years of age. The intent to treat population consisted of 53 pts randomized to continue therapy with RAI (n=25) or switch to HRI (n=28). Non-inferiority for change in A1C between groups was demonstrated in this population. Insulin dose and hypoglycemia events were similar between groups. No severe hypoglycemia or moderate or severe adverse events were reported in either group. Similar to the overall study findings, use of HRI delivered by V-Go is an effective insulin therapy option in an older population and may decrease financial burdens.

Disclosure
D.R. Sutton: Employee; Spouse/Partner; Valeritas, Inc. Speaker’s Bureau; Self; Amarin Corporation, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Merck & Co., Inc., Novo Nordisk A/S, Valeritas, Inc. P.F. Mora: Speaker’s Bureau; Self; Dexcom, Inc., Insulet Corporation, Janssen Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk Inc., Sanofi US, Valeritas, Inc. A. Gore: Advisory Panel; Spouse/Partner; Janssen Pharmaceuticals, Inc. Consultant; Spouse/Partner; Janssen Pharmaceuticals, Inc. Consultant; Self; Novo Nordisk Inc. Speaker’s Bureau; Spouse/Partner; Janssen Pharmaceuticals, Inc. Speaker’s Bureau; Self; Janssen Pharmaceuticals, Inc., Merck & Co., Inc. B. Baliga: Speaker’s Bureau; Self; Amarin Corporation, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Lilly Diabetes, Novo Nordisk Inc., Senseonics, Valeritas, Inc. R.F. Goldfaden: None. C.C. Nikkel: Employee; Self; Valeritas, Inc. Stock/Shareholder; Self; Valeritas, Inc. J.H. Sink: Employee; Self; Valeritas, Inc. B.A. Adams-Huet: Consultant; Self; Valeritas, Inc.

Funding
Valeritas, Inc.
995-P: Real-World Insulin Delivery Patterns for 1,202 Adults with Type 2 Diabetes Using the Omnipod Insulin Management System with Cloud-Based Data Management
Authors: HIRSCH IRL B. , WEINSTOCK RUTH S. , HUYETT LAUREN M. , JANTZ JAY , CHANG ALBERT , VIENNEAU TODD , LY TRANG T. 
Published: June 2020

Insulin pump therapy is increasing in T2D but real-world use has not been well studied. This report describes insulin delivery and glucose data from adults with T2D using a tubeless insulin pump (Omnipod® Insulin Management System, Acton, MA) with an integrated blood glucose (BG) meter (Abbott Diabetes Care Inc., Alameda, CA) and data management system (DMS; Glooko, Mountain View, CA). Pump system usage data uploaded to the DMS from Feb.-Aug. 2019 were linked to a database of self-reported demographic data and de-identified. Insulin and BG data from ≥3 mo of system use per user were analyzed.
Adults (n=1,202) were aged (mean±SD) 58±11 yr: 47% female, 28% aged ≥65 yr. Total daily insulin was 61±29 units/d delivered as 60±16% basal. Percentage of total daily insulin from basal delivery was ≥50% for 73% of users, and ≥70% for 26%. Only 4.5% and 0.6% of users received ≥90% or &lt;20% of daily insulin from basal delivery, respectively. Users bolused 3.5±1.9 x/d, with 7.8±4.5 units/bolus. Average bolus frequency was ≥1x/d for 95% of users, ≥2x/d for 81%, ≥3x/d for 55%, ≥4x/d for 29%, and ≥5x/d for 16%. About 1 in 5 regularly used the extended bolus or temporary basal rate features (EB/TBR, ≥3.33% of days with gaps &lt;60 days, ≥3mo of use). BG test frequency was 2.1±1.5 x/d for those who used the integrated BG meter (n=853). Among these users, those who bolused &lt;3 x/d (n=387) had a mean BG of 180±52 mg/dL, while those who bolused ≥3 x/d (n=466) had a mean BG of 167±36 mg/dL (p&lt;0.001). Regular EB/TBR users (n=189) had a mean BG of 162±36 vs. 176±46 mg/dL for infrequent users (&lt;3.33% of days, n=619, p&lt;0.001).
These real-world data demonstrate positive self-management behaviors among a large cohort of adults with T2D using a tubeless insulin pump. Both basal and bolus insulin delivery were used by ≥95%, with 81% bolusing at least twice per day, and 22% using EB/TBR features. These results support the tubeless pump as a practicable option for those with T2D requiring insulin therapy.

Disclosure
I.B. Hirsch: Consultant; Self; Abbott, Bigfoot Biomedical, Roche Diabetes Care. Research Support; Self; Medtronic, Omnipod. R.S. Weinstock: Board Member; Self; JDRF. Consultant; Self; Insulogic LLC. Research Support; Self; Boehringer Ingelheim International GmbH, Diasome Pharmaceuticals, Inc., Eli Lilly and Company, Insulet Corporation, Jaeb Center for Health Research, Kowa Research Institute, Inc., Medtronic, Tolerion, Inc. L.M. Huyett: Employee; Self; Insulet Corporation. J. Jantz: Employee; Self; Insulet Corporation. A. Chang: Employee; Self; Insulet Corporation. Stock/Shareholder; Self; Insulet Corporation. T. Vienneau: Employee; Self; Insulet Corporation. Stock/Shareholder; Self; Insulet Corporation. T.T. Ly: Employee; Self; Insulet Corporation.

Funding
Insulet Corporation
KOMPLIKASI MATERNAL DAN LUARAN BAYI BARU LAHIR PADA KEHAMILAN REMAJA DI RUMAH SAKIT UMUM DAERAH KANJURUHAN, KEPANJEN, MALANG
Authors: Tarsikah Tarsikah , Diba Dyah Ayu Amira , Didiharto Henri 
Published: June 2020

Kehamilan remaja menjadi salah satu permasalahan kesehatan yang serius di dunia karena berpotensi menimbulkan risiko pada ibu maupun bayi. Tujuan dari penelitian ini adalah untuk mengetahui gambaran komplikasi maternal dan luaran bayi baru lahir pada kehamilan remaja. Desain penelitian deskriptif kuantitatif. Populasi yang seluruh bayi baru lahir dari ibu usia remaja tahun 2017 sampai 2018 di RSUD Kanjuruhan Kepanjen Malang sejumlah 75 orang dengan menggunakan teknik total sampling. Instrumen yang digunakan adalah rekam medis dan cek list pengumpulan data. Analisis data menggunakan univariat yang disajikan dalam distribusi frekuensi. Hasil penelitian menunjukkan sebagian kecil terjadi komplikasi maternal (25,3%) dengan insiden terbanyak adalah ketuban pecah dini (8%). Luaran bayi baru lahir pada kehamilan remaja didapatkan usia gestasi cukup bulan (53,3%), berat badan lahir rendah (54,7%), APGAR skor <7 (54,7%). Risiko komplikasi akibat kehamilan pada remaja bisa diminimalkan dengan upaya kontak secara dini dengan pelayanan kesehatan dan melakukan pemeriksaan ante natal secara teratur.
APPLICATION OF BENZYLADENINE (BA) IN THE FORM OF LANOLIN PASTE ON FLOWER-STALK BUDS SUCCESSFULLY INDUCED RE-BLOOMING OF HYBRID Phalaenopsis
Authors: Iryani Mukhaila , Yusnita Yusnita , Hapsoro Dwi , Setiawan Kukuh , Karyanto Agus 
Published: June 2020

Hybrid moth orchid (genus Phalaenopsis) is one of the most popular ornamentals in Indonesia. It has beautiful and long-lasting flowers, but cultivating this orchid is still become a challenging issues due to the need of specific condition to grow and long time period to re-blooming. Plant growth regulators (PGR) (i.e. Benzyladenine (BA)) has been widely documented as a flower-inducing substance in several orchids. However, the optimal concentration and its mechanism in inducing flower-stalk bud and re-blooming is still unclear. This research aimed to study the effects of BA application in the form of lanolin paste on hybrid Phalaenopsis flower-stalk buds. We conducted this study using completely randomized design with four replications at the greenhouse laboratory Faculty of Agriculture University of Lampung on August to December 2018. We divided the orchid into 5 group of BA concentration (0, 1000, 1500, 3000, or 6000 ppm). The sheath of the fourth or fifth buds of the flowers were carefully opened, then it smeared with BA. The percentage of bud break into flower spike or keiki, length of shoots or spike and number of open flowers were recorded until 10 weeks of observation. The results showed that, neither of the buds under the control treatment (without BA), 1000 ppm nor 1500 ppm BA broke and grew into keiki or spike. On the other hand, application of BA at 3000 ppm or 6000 ppm successfully induced 100% flower spikes on the buds treated. No keiki was formed in all buds treated. In addition, treatment of the buds with 6000 ppm BA produced longer flower spikes as well as more open flowers. We conclude that the application of BA (minimal 3000 ppm) successfully induced flower spike of hybrid Phalaenopsis.
Use of percutaneous transvenous coil embolization in the treatment of intrahepatic portosystemic shunts in four cats
Authors: Culp William T. N. , Griffin Maureen A. , Case J. Brad , Zwingenberger Allison L. , Marks Stanley L. 
Published: June 2020

Abstract

CASE DESCRIPTION
4 cats (6 to 9 months old) were evaluated because of clinical signs consistent with a portosystemic shunt (PSS).

CLINICAL FINDINGS
Among the 4 cats, 3 had neurologic abnormalities including ataxia, head pressing, disorientation, and obtundation. One cat was evaluated because of urethral obstruction; a retrieved urethral stone was determined to have urate composition. Clinicopathologic findings (hypoproteinemia, low BUN concentration, and high serum bile acids concentration) were consistent with a PSS in all cats. A diagnosis of intrahepatic PSS (IHPSS) was made for all cats on the basis of ultrasonographic and CT findings.

TREATMENT AND OUTCOME
All cats underwent percutaneous transvenous coil embolization (PTCE). No major intraprocedural complications were encountered, and all cats were discharged from the hospital. For the 3 cats that were presented with neurologic signs, an evaluation performed at 12, 14, or 48 months after the procedure revealed resolution of the neurologic signs, and owners reported that the behavior of each cat appeared normal. One cat that initially had neurologic and gastrointestinal signs had lower urinary tract signs after PTCE and developed an acquired extrahepatic PSS.

CLINICAL RELEVANCE
Although IHPSSs in cats are uncommon, the outcomes of PTCE for the 4 cats of the present report suggested that this treatment may benefit cats with an IHPSS. No short-term complications were encountered, and all cats had improvement in clinical signs following PTCE, although an acquired extrahepatic PSS was later identified in 1 cat. Further investigation of the use of endovascular techniques for the treatment of IHPSSs in cats and other species is warranted.
(k,m)-type slant helices for partially null and pseudo null curves in Minkowski space
𝔼14{\rm{\mathbb E}}_1^4
Authors: Bektaş Mehmet , Yilmaz Münevver Yildirim 
Published: June 2020

Abstract
In this study we define the notion of (k,m)-type slant helices in Minkowski 4-space and express some characterizations for partially and pseudo null curves in

𝔼
1
4

{\rm{\mathbb E}}_1^4

.
PENGARUH SUHU PENCELUPAN TERHADAP KARAKTERISTIK MINUMAN TEH HERBAL KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)
Authors: Ardianta I Komang , Yusa Ni Made , Putra I Nengah Kencana 
Published: June 2020

This research aimed to find out effect of the dipping water temperature on characteristics of herbal tea drink from red dragon fruit peel. This study used the completely random design of treatment with dipping temperature treatment 50oC, 60oC, 70oC, 80oC, 90oC and 100oC. The treatment was repeated in 3 replications, resulting in 18 experimental units. Data were analyzed by variance analysis and continued with Duncan's test. The results showed that the dipping temperature of herbal tea drink from red dragon fruit peel affected the total phenol, antioxidant activity, color taste and overall appearance. The best treatment was obtained with temperature of 100oC which produced herbal tea drinks with antioxidant activity (IC50) which was 8.50 mg/ml, juice content 1.94%, total phenol 0.83 g/100g, and sensory characteristics of color was very red color and liked, ordinary aroma, taste liked and overall acceptance liked.
PENGARUH LAMA FERMENTASI OLEH Bacillus subtilis TERHADAP KARAKTERISTIK SERE KEDELE
Authors: Sipayung Sri Madiarti , Rai Widarta I Wayan , Kartika Pratiwi I Desak Putu 
Published: June 2020

This research aims to find out the effect of soybean fermentation time by Bacillus subtilis to produce sere kedele with the best characteristics. This research used completely randomized design (CRD) with one treatment factor of the fermentation time with 5 period of fermentation time (12, 18, 24, 30 and 36h). Each treatment was repeated 3 times, resulted 15 experimental units. The data were then analyzed with Analysis of Variance method and if the treatment had an effect on the variable, followed by the Duncan test. The result show that fermentation times had significant effect to moisture, ash, protein, fat, carbohydrate, crude fiber content, total acid, pH value, the number microbes, hedonic test for taste, scoring test for taste and overall acceptance of sere kedele. Fermented by B. subtilis for 12h resulted in the best characteristic under the following criteria : 58.05% moisture content, 2.39% ash content, 15.79% protein content, 14.39% fat contetnt, 9,38% carbohydrate content, 6.1 pH value, 0.11% total acid, 9.59log cfu/g the number microbes, color, flavour, texture liked, normal taste with sour taste and overall acceptance liked.

Keyword : soybean, sere kedele, Bacillus subtilis, fermentation, traditional food .
STUDI SIFAT FISIK, KIMIA, FUNGSIONAL, DAN KADAR ASAM SIANIDA TEPUNG KECAMBAH KACANG KORO PEDANG (Canavalia ensiformis L.)
Authors: Damayanti I Dewa Ayu Bintang , Wisaniyasa Ni Wayan , Widarta I Wayan Rai 
Published: June 2020

The purpose of this research was to determine the physical, chemical, functional properties, and hydrogen cyanide content of jack bean sprout (Canavalia ensiformis L.) flour. This research used two treatments that was without germination and 48 hours of germination. The treatments were repeated three times resulting in six units of experiments. Jack bean flour and jack bean sprout flour were analyzed by paired T-test. The results showed that the germination of jackbean had a very significant effect on the decrease of oil absorption from 1.59 mg/l to 0.79 mg/l. The treatment had a significant effect on the increase of water content from 11.10% to 11.77%; increase of protein content from 28.52% to 29.18%; decrease of fat content from 6.33% to 5.54%; decrease of carbohydrate content from 51.19% to 50.77%; increase of crude fiber content from 11.69% to 12.30%; increase of water holding capacity from 1.42 ml/g to 1.58 ml/g; decrease of swelling volume from 8.97 ml/g to 8.31 ml/g; increase of solubility from 0.06% to 0.07%; and decrease of hydrogen cyanide content from 14.13 mg/kg to 11.00 mg/kg. This research had no effect on bulk density and ash content.

Keywords : hydrogen cyanide; jackbean sprout flour; chemical, functional and physical properties