bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracking the evolution of circulating exosomal‐PD‐L1 to monitor melanoma patients
Authors: Cordonnier Marine , Nardin Charlée , Chanteloup Gaëtan , Derangere Valentin , Algros Marie‐Paule , Arnould Laurent , Garrido Carmen , Aubin François , Gobbo Jessica 
Published: January 2020

ABSTRACTIn the era of immunotherapies there is an urgent need to implement the use of circulating biomarkers in clinical practice to facilitate personalized therapy and to predict treatment response. We conducted a prospective study to evaluate the usefulness of circulating exosomal‐PD‐L1 in melanoma patients’ follow‐up. We studied the dynamics of exosomal‐PD‐L1 from 100 melanoma patients by using an enzyme‐linked immunosorbent assay. We found that PD‐L1 was secreted through exosomes by melanoma cells. Exosomes carrying PD‐L1 had immunosuppressive properties since they were as efficient as the cancer cell from which they derive at inhibiting T‐cell activation. In plasma from melanoma patients, the level of PD‐L1 (n= 30, median 64.26 pg/mL) was significantly higher in exosomes compared to soluble PD‐L1 (n= 30, 0.1 pg/mL). Furthermore, exosomal‐PD‐L1 was detected in all patients whereas only 67% of tumour biopsies were PD‐L1 positive. Although baseline exosomal‐PD‐L1 levels were not associated with clinic‐pathologic characteristics, their variations after the cures (ΔExoPD‐L1) correlated with the tumour response to treatment. A ΔExoPD‐L1 cut‐off of> 100 was defined, yielding an 83% sensitivity, a 70% specificity, a 91% positive predictive value and 54% negative predictive values for disease progression. The use of the cut‐off allowed stratification in two groups of patients statistically different concerning overall survival and progression‐free survival. PD‐L1 levels in circulating exosomes seem to be a more reliable marker than PD‐L1 expression in tumour biopsies. Monitoring of circulating exosomal‐PD‐L1 may be useful to predict the tumour response to treatment and clinical outcome.
Determining the shape of reflectance reference samples for curved surface reflectors
Authors: Lanevski Dmitri , Manoocheri Farshid , Vaskuri Anna , Hameury Jacques , Kersting Robert , Monte Christian , Adibekyan Albert , Kononogova Elena , Ikonen Erkki 
Published: January 2020

Abstract
Foils made of different materials are often used as reflective insulators. Many manufacturers aim to accurately measure their optical properties to estimate and improve their performance. However, flat reflectance reference samples used in measurements do not correctly represent reflective insulators and cause discrepancies between different measurement techniques. The current work presents a method for modelling surface shape of appropriate reflectance reference samples that could be produced by additive manufacturing. The method is based on studying the reflection distribution of reflective insulators and is described with an example of aluminium foil. The method’s performance is validated using Monte-Carlo simulations.
Two- and three-terminal far-from-equilibrium thermoelectric nano-devices in the Kondo regime
Authors: Eckern Ulrich , Wysokiński Karol I 
Published: January 2020

Abstract
This paper analyses the thermoelectric power of two- and three-terminal quantum dot devices under large thermal ΔT and voltage V biases, and their performance as thermoelectric heat engines. The focus is on the interaction between electrons, far-from-equilibrium conditions, and strongly nonlinear transport, which all are important factors affecting the usefulness of the devices. To properly characterise the thermoelectric properties under such conditions, two different Seebeck coefficients are introduced, generalizing the linear response expression. In agreement with previous work, we find that the efficiency of the three-terminal thermoelectric heat engine, as measured by the delivered power, is optimal far from equilibrium. Moreover, strong Coulomb interactions between electrons on the quantum dot are found to diminish the efficiency at maximum power, and the maximal value of the delivered power, both in the Kondo regime and beyond.
Polarization in

decays *
Authors: Han Tong-Zhu , Ping Rong-Gang , Luo Tao , Xu Guang-Zhi 
Published: January 2020

Abstract
Measurements of decay asymmetry parameters of charmed baryons, e.g.,

, provide more data to test the W-emission and W-exchange mechanisms controlled by strong and weak interactions. Taking advantage of the spin polarization in charmed baryon decays, we investigate the possibility to measure weak decay asymmetry parameters in the

process. We analyze the transverse polarization spontaneously produced in this process and the spin transfer in the subsequent

decays. The sensitivity to measure the asymmetry parameters is estimated for the decay

.
The

semileptonic decay within the LCSR approach under heavy quark effective field theory *
Authors: Zhou Rui-Yu , Guo Lei , Fu Hai-Bing , Cheng Wei , Wu Xing-Gang 
Published: January 2020

Abstract
The heavy quark effective field theory (HQEFT) provides an effective way to deal with heavy meson decays. In this paper, we adopt two different correlators to derive the light-cone sum rules (LCSR) for the

transition form factors (TFFs) in the framework of HQEFT. We label the two LCSR results as LCSR-

and LCSR-

, which stand for the conventional correlator and the right-handed correlator. We observe that the correlation parameter

for the branching ratio

is

, implying a consistency of LCSRs with the other correlators. Furthermore, we obtain

and

. We also obtain

and

, both of which agree with the lattice QCD predictions. Thus, HQEFT provides a useful framework for studying B meson decays. Moreover, by using the right-handed correlator, the twist-2 terms are dominant in TFF

, as their contribution is over ~97% in the whole

region, while the large twist-3 uncertainty of the conventional correlator is greatly suppressed. Hence, the LCSR-

predictions can be used to test the properties of the various models for the pion twist-2 distribution amplitudes.
Deformed dispersion relation constraint with hydrogen atom 1S-2S transition *
Authors: Pu Jin , Li Guo-Ping , Jiang Qing-Quan , Zu Xiao-Tao 
Published: January 2020

Abstract
We use the latest results of the ultra-high accuracy 1S-2S
transition experiments in the hydrogen atom to constrain the forms of the deformed dispersion relation in the non-relativistic limit. For the leading correction of the non-relativistic limit, the experiment sets a limit at an order of magnitude for the desired Planck-scale level, thereby providing another example of the Planck-scale sensitivity in the study of the dispersion relation in controlled laboratory experiments. For the next-to-leading term, the bound is two orders of magnitude away from the Planck scale, however it still amounts to the best limit, in contrast to the previously obtained bound in the non-relativistic limit from the cold-atom-recoil experiments.
Constituent quark number scaling from strange hadron spectra in pp collisions at

TeV *
Authors: Zhang Jian-Wei , Li Hai-Hong , Shao Feng-Lan , Song Jun 
Published: January 2020

Abstract
We show that the

spectra of

and

at midrapidity in the inelastic events in

collisions at

13 TeV exhibit a constituent quark number scaling property, which is a clear signal of quark combination mechanism at hadronization. We use a quark combination model with equal velocity combination approximation to systematically study the production of identified hadrons in

collisions at

= 13 TeV. The midrapidity

spectra for protons,

,

,

,

and

in the inelastic events are simultaneously fitted by the model. The multiplicity dependence of the yields of these hadrons are also well understood. The strong

dependence of the

ratio is well explained by the model, which further suggests that the production of two hadrons with similar masses is determined by their quark content at hadronization. The

spectra of strange hadrons at midrapidity in different multiplicity classes in

collisions at

13 TeV are predicted for further tests of the model. The midrapidity

spectra of soft (

GeV/c) strange quarks and up/down quarks at hadronization in

collisions at

13 TeV are extracted.
Skyrmion stability at finite isospin chemical potential and temperature *
Authors: Yuan Wen-Li , Xu Zhen-Ni , Zhang Jin-Li , Zong Hong-Shi 
Published: January 2020

Abstract
The skyrmion stability at finite isospin chemical potential

is studied using the Skyrme Lagrangian with a finite pion mass

. A critical value

, above which a stable soliton does not exist, is found. We also explore some properties of the skyrmion as function of

, i.e., the isoscalar rms radius and the isoscalar magnetic rms radius. Finally, considering the finite temperature effect on the skyrmion mass, we obtain a critical temperature

, using the profile function of the skyrmion, above which the skyrmion mass does not have a minimum, which can be interpreted as the occurrence of the deconfinement phase transition.
Isotopic cross-sections in proton induced spallation reactions based on the Bayesian neural network method *
Authors: Ma Chun-Wang , Peng Dan , Wei Hui-Ling , Niu Zhong-Ming , Wang Yu-Ting , Wada R. 
Published: January 2020

Abstract
The Bayesian neural network (BNN) method is proposed to predict the isotopic cross-sections in proton induced spallation reactions. Learning from more than 4000 data sets of isotopic cross-sections from 19 experimental measurements and 5 theoretical predictions with the SPACS parametrization, in which the mass of the spallation system ranges from 36 to 238, and the incident energy from 200 MeV/u to 1500 MeV/u, it is demonstrated that the BNN method can provide good predictions of the residue fragment cross-sections in spallation reactions.
Weak cosmic censorship conjecture in BTZ black holes with scalar fields *
Authors: Chen Deyou 
Published: January 2020

Abstract
The weak cosmic censorship conjecture in the near-extremal BTZ black hole has been tested using test particles and fields. It has been claimed that such a black hole can be overspun. In this paper, we review the thermodynamics and weak cosmic censorship conjecture in BTZ black holes using the scattering of a scalar field. The first law of thermodynamics in the non-extremal BTZ black hole is recovered. For the extremal and near-extremal black holes, due to the divergence of the variation of entropy, we test the weak cosmic censorship conjecture by evaluating the minimum of the function f, and find that both the extremal and near-extremal black holes cannot be overspun.
Tunneling of massive vector particles under influence of quantum gravity *
Authors: Javed Wajiha , Ali Riasat , Babar Rimsha , Övgün Ali 
Published: January 2020

Abstract
This study set out to investigate charged vector particles tunneling via horizons of a pair of accelerating rotating charged NUT black holes under the influence of quantum gravity. To this end, we use the modified Proca equation incorporating generalized uncertainty principle. Applying the WKB approximation to the field equation, we obtain a modified tunneling rate and the corresponding corrected Hawking temperature for this black hole. Moreover, we analyze the graphical behavior of the corrected Hawking temperature

with respect to the event horizon for the given black hole. By considering quantum gravitational effects on Hawking temperatures, we discuss the stability analysis of this black hole. For a pair of black holes, the temperature

increases with the increase in rotation parameters a and

, correction parameter

, black hole acceleration

, and arbitrary parameter k, and decreases with the increase in electric e and magnetic charges g.
Healing effect in coatings deposited by hybrid technology of vacuum electro-spark alloying, pulsed cathodic arc evaporation, and magnetron sputtering using Cr3C2-NiAl electrodes
Authors: Kiryukhantsev-Korneev Ph V , Shvyndina N V , Sytchenko A D , Shtansky D V , Gorshkov V A , Levashov E A 
Published: January 2020

Abstract
The single- and multilayer coatings were deposited by methods of vacuum electro-spark alloying (VESA), pulsed cathodic arc evaporation (PCAE), magnetron sputtering (MS) and by hybrid VESA-PCAE, VESA-MS and VESA-PCAE-MS technologies. Cr3C2-NiAl electrodes obtained by self-propagating high-temperature synthesis (SHS) were used for coating deposition. The results of structural studies by scanning electron microscopy are presented. It was shown that the surface defects of the VESA layer can be successfully healed by applying the upper layer by ion-plasma PCAE or MS methods.
Central Taiwan’s hydroclimate in response to land use/cover change
Authors: Chen Chia-Jeng , Chen Chu-Chun , Lo Min-Hui , Juang Jehn-Yih , Chang Che-Min 
Published: January 2020

Abstract
Land use/cover change (LUCC) has taken place since the 1990s in central Taiwan; however, its impacts on the local and regional hydroclimatology are not understood thoroughly. This study is grounded in a numerical experiment using the Weather Research and Forecasting (WRF) model and statistical assessments of continuous land cover and gridded precipitation data derived for central Taiwan. We incorporate survey-based land use data in 1995 and 2007 in driving WRF to simulate selective non-rainy and rainy (dry and wet) cases under weak synoptic forcings in July and August (JA). The two land-use conditions reveal changes in simulation fields on account of increased urban and built-up lands. Results averaged over the dry cases show increased (diminished) sensible heat fluxes and 2 m temperatures (latent heat fluxes and 2 m specific humidity) in 2007 compared to that in 1995. The wet-case simulation further identifies intensified precipitation over the downwind areas of urban and built-up lands, strongly subject to local topography and prevailing winds. Statistical assessments of the Landsat land cover and gridded precipitation data verify significant increasing trends in urbanization and the JA rainfall. Regression-based analysis that scales the effect of the LUCC on the change in precipitation corroborates the WRF simulation: LUCC has induced eastward, downwind association with the JA rainfall.
Effects of drought on hay and feed grain prices
Authors: Schaub Sergei , Finger Robert 
Published: January 2020

Abstract
Droughts represent a severe and increasing risk for the livestock sector as they can reduce yields of hay and feed grain. Droughts are predicted to increase in frequency and magnitude under climate change. Here we estimate the so far unexplored effect of drought shocks on feed prices. We use an empirical example from Germany and focus on the prices of hay as well as feed wheat and barley. Our results show that regional and national droughts substantially increase hay prices by up to 15%, starting with a delay of about 3 months and lasting for about a year. In contrast, feed grain prices in our sample are not affected by regional or national droughts. These price responses can be linked to market integration, as the hay market is usually regionally organized while feed grains are traded transnationally. It is important to include this knowledge into farm management and policy actions, especially considering climate change.
Overview of the II International Conference on Agribusiness, Environmental Engineering and Biotechnologies - AGRITECH-II - 2019
Authors: Kovalev Igor V , Pyzhikova N I , Voroshilova Anna A 
Published: January 2020

Abstract
The overview describes the main directions and results of the International Conference “AGRITECH-II-2019” held in Krasnoyarsk in November 13-14, 2019. It gives the details about the participants and the proceedings. The anchor partner of Krasnoyarsk Science and Technology City Hall was Krasnoyarsk State Agrarian University. A description of the main trends in modern agribusiness science as well as in the development of the university are given in the overview.
The possibility of using the PPP mechanism (public-private partnership) in the construction of logistics centers for processing and marketing of agricultural products
Authors: Subbotin A S , Krents Y V , Tarasenkova A A 
Published: January 2020

Abstract
The article deals with topical issues of the possibility of using the mechanism of public private partnership in the construction of logistics centers for processing and marketing of agricultural products. The development of the agro-industrial complex creates a favorable atmosphere for cooperation between the state and private business. The use of this mechanism allows both parties to obtain the maximum benefit from such an Alliance. It is necessary to consider the possibility, prospects and economic efficiency as a result of the construction of logistics complexes for agricultural products. The favorable outcome will be the opportunity for farmers and the local population to sell their products, an increase in the number of jobs and an increase in the reserves of the raw material base. The article presents the prospects for the use of the PPP mechanism in the construction of logistics centers of the agro-industrial complex. The authors of the article analyze the effectiveness of this mechanism in modern conditions and put forward proposals to optimize the process.
Determination of safe conditions for moving ears to the working surface of the plant for sorting ears of seed corn
Authors: Kotelevskaya E A , Klasner G G , Tolstov K S 
Published: January 2020

Abstract
The article presents a theoretical justification for sorting corn ears on the developed plant and proposes a solution in the form of a working surface of varying curvature consisting of descending and ascending surfaces. The conditions under which the sparing mode is created for reloading the cobs are determined, the dynamic parameters for moving the cobs along the descending and ascending surfaces and by the grapho-analytical method are determined by intervals of their values corresponding to the sparing regime. The obtained theoretical dependences take into account the physical and mechanical properties of corn cobs.
Ionizing radiation treatment as an innovative process approach in food storage technology for modern agriculture
Authors: Timakova R T , Tikhonov S L , Tikhonova N V 
Published: January 2020

Abstract
The article presents the results of the identification of chilled imported rainbow trout to establish the fact of irradiation in the study of bone tissue by electron paramagnetic resonance (EPR) on a modern domestic EPR X-band spectrometer of Labrador Expert brand. It was established that imported trout was previously treated with ionizing radiation, and information on the processing method in violation of regulatory requirements was not communicated to consumers. Implementation of an innovative process approach when choosing a technology for processing food products with ionizing radiation allows us to provide high organoleptic characteristics during storage for up to 15 days, maintaining freshness indicators (acid number, peroxide number) at the normal level and prolonging shelf life. Proven processing efficiencies to ensure microbiological safety. The results are of practical and methodological importance for the implementation of radiobiological control of previously irradiated food products and the justification of the possibility of using ionizing radiation in the technological process at the enterprises of the agro-industrial complex to extend shelf life based on an innovative process approach to the choice of storage technologies.
Features of biotechnological processes of bread production enriched with inulin-containing raw materials
Authors: Ermosh L G , Safronova T N , Prisuhina N V 
Published: January 2020

Abstract
Bread takes a leading place in the diet of all socio-demographic groups of the population, therefore, it should have not only high taste, but also significant nutritional value. Vitamin B, starch, dietary fiber, and minerals are daily supplied with bread to the human body. However, bread has a deficiency of vitamin C, iron, calcium, pectin, and other functional components. This involves enriching bread with various additives with functional properties. However, the introduction of various fillers ambiguously affects the biochemical processes of the development of yeast cells, fermentation and maturation of the test, baking processes, which largely depends on the chemical composition of the additive. This paper presents the rationale for the use of inulin-containing raw materials - powder from Jerusalem artichoke tubers in the production of yeast bread. The effect of the powder on the biotechnological processes of dough formation, quality indicators and nutritional value of the finished bread, staling processes is investigated. The results of the work made it possible to create new types of bread with high consumer properties, containing inulin, an increased amount of fiber and pectin and minerals that have prophylactic properties, including diabetes.
Improvement of antifriction properties of sliding bearings with ceramic sleeves made of zirconium dioxide
Authors: Alisin V V , Roshchin M N 
Published: January 2020

Abstract
The article is devoted to the investigation of the tribological properties of a sliding bearing with a ceramic sleeve made of zirconium dioxide powder stabilized with yttrium oxide. The paper studies antifriction properties of a bearing under friction without lubrication in the range of contact pressure of 0.05 - 0.5 MPa at the speed of 0.5 - 3 m/s in relation to the operating conditions of the support of a submersible centrifugal pump for oil production. The possibilities of improving the antifriction bearing’s properties by processing a ceramic sleeve in selenium vapor are analyzed. The assumption about the prospects of using ceramic sleeves with a modified friction surface in the chemical and oil-gas industry is justified.
Hematologic markers of stress resistance of service Belgian Shepherd Dog (Malinois)
Authors: Sadykova Y R , Krylova I O , Kornilova E A , Tikhonova T V 
Published: January 2020

Abstract
The morphological composition, the level of thyroxine and cortisol in the blood and the crystallogram of blood serum in 36 service Belgian shepherd dogs (malinois) of specialized military kennels of Russia were studied. The tendencies of changes in the blood formula depending on age, season, gender, category of use were identified. In a physiologically mature age, malinois has a higher platelet count, hemoglobin. In repair (training) animals older than two years, the leukogram and crystallogram are more stable, regardless of the season, while the correlation with the hormones thyroxine and cortisol is higher in younger animals. Belgian shepherd dogs in service categories have a tense adaptive status according to the Garkavi stress reactivity index. Significantly fewer monocytes and more lymphocytes in the raspberry mine search service, which corresponds to the reactivation reaction. According to the morphological picture of crystallograms in service malinois, a depressive and reactive state prevails. It is recommended to select malinois for official use more carefully.