bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Nuberu Bagu y el nuevo Japón
Authors: Santos Antonio 
Published: April 2020

En 1956 se estrenaron en Japón tres largometrajes basados en novelas de Shintaro Ishihara. Su éxito originará una serie de películas, antesala de la Nuberu Bagu: un joven cine encaminado a la transformación radical del séptimo arte y de la sociedad japonesa, cuyos representantes se muestran muy críticos con su tiempo. Los trabajos innovadores que realizaron estos jóvenes cineastas autorizaron a algunos críticos a reconocer en ellos la vanguardia de una Nueva Ola. El ejemplo más distinguido de esta desviación hacia posiciones radicales lo proporcionó Nagisa Oshima con sus Historias crueles de juventud (1960).
Comparten estos jóvenes cineastas parecido interés por la exploración formal, encaminado a la renovación del lenguaje; un movimiento radical y revolucionario, orientado a practicar una nueva lectura.
Confessional and Migration Factors of Economic Development of the East Siberian Region
Authors: ARZUMANOV Igor A. , KAMEDINA Lyudmila V. , LICHICHAN Oleg P. 
Published: April 2020

The research examines the issues related to the influence of confessional and migration factors on the processes of the integrated territorial development in the Russian Federation. The analysis of the documents of strategic planning of socio-economic and demographic territorial development employed the methods of cultural and religious studies as well as socio-cultural, comparative legal and formal legal methods in the framework of the dialectic approach. The research reveals a correlation between the destruction of socio-economic development processes and the demographic stagnation factor. An analysis of potential threats to sociopolitical stability as a result of the intensification of migration processes and the activities of religious institutions in the East Siberian region is given. It is concluded that the confessional factor potentially plays a destabilizing role in the implementation of federal targeted programs aimed at the integration of Russian society.
Urokinase-Type Plasminogen Activator Protects Cerebral Cortical Neurons from Soluble Aβ-Induced Synaptic Damage
Authors: Diaz Ariel , Merino Paola , Guo Ji-Dong , Yepes Manuel A. , McCann Patrick , Katta Tapasya , Tong Elise M. , Torre Enrique , Rangaraju Srikant , Yepes Manuel 
Published: April 2020

Soluble amyloid β (Aβ)-induced synaptic dysfunction is an early event in the pathogenesis of Alzheimer's disease (AD) that precedes the deposition of insoluble Aβ and correlates with the development of cognitive deficits better than the number of plaques. The mammalian plasminogen activation (PA) system catalyzes the generation of plasmin via two activators: tissue-type (tPA) and urokinase-type (uPA). A dysfunctional tPA-plasmin system causes defective proteolytic degradation of Aβ plaques in advanced stages of AD. In contrast, it is unknown whether uPA and its receptor (uPAR) contribute to the pathogenesis of this disease. Neuronal cadherin (NCAD) plays a pivotal role in the formation of synapses and dendritic branches, and Aβ decreases its expression in cerebral cortical neurons. Here we show that neuronal uPA protects the synapse from the harmful effects of soluble Aβ. However, Aβ-induced inactivation of the eukaryotic initiation factor 2α halts the transcription of uPA mRNA, leaving unopposed the deleterious effects of Aβ on the synapse. In line with these observations, the synaptic abundance of uPA, but not uPAR, is decreased in the frontal cortex of AD patients and 5xFAD mice, and in cerebral cortical neurons incubated with soluble Aβ. We found that uPA treatment increases the synaptic expression of NCAD by a uPAR-mediated plasmin-independent mechanism, and that uPA-induced formation of NCAD dimers protects the synapse from the harmful effects of soluble Aβ oligomers. These data indicate that Aβ-induced decrease in the synaptic abundance of uPA contributes to the development of synaptic damage in the early stages of AD.SIGNIFICANCE STATEMENTSoluble amyloid β (Aβ)-induced synaptic dysfunction is an early event in the pathogenesis of cognitive deficits in Alzheimer's disease (AD). We found that neuronal urokinase-type (uPA) protects the synapse from the deleterious effects of soluble Aβ. However, Aβ-induced inactivation of the eukaryotic initiation factor 2α decreases the synaptic abundance of uPA, leaving unopposed the harmful effects of Aβ on the synapse. In line with these observations, the synaptic expression of uPA is decreased in the frontal cortex of AD brains and 5xFAD mice, and uPA treatment abrogates the deleterious effects of Aβ on the synapse. These results unveil a novel mechanism of Aβ-induced synaptic dysfunction in AD patients, and indicate that recombinant uPA is a potential therapeutic strategy to protect the synapse before the development of irreversible brain damage.
Cyber-physical platform development and implementation for industry 4.0
Authors: Szász Csaba 
Published: April 2020

AbstractIndustry 4.0 is referred as the fourth industrial revolution that represents the information intensive transformation of industrial automation and manufacturing processes. Cyber-physical systems (CPS) are building blocks in Industry 4.0 and part of the Industry 4.0 vision. This paper presents a cyber-physical platform development and implementation strategy for Industry 4.0 applications. It has been considered a cyber-physical platform model (CPP) built upon hardware reconfigurable technology based on a Field Programmable Gate Array (FPGA) processor framework. The development strategy exploits the full benefits enabled by reconfigurable hardware, such as scalability of complex systems, platform-based design approach, adaptive processing, real-time constrains management, or high performance prototyping capabilities. The implemented experimental setup also combines major advantages of both the hardware and software platform-based design trends in Industry 4.0. In this endeavor, the used software toolkit comprises the entire system complexity as a high performance integration layer. The presented design method and implementation strategy can serve as rough orientation for future CPS research and development activities.
Detection of metallo-Î²-lactamase gene blaIMP of Escherichia coli clinical isolates in Sanglah General Hospital Bali
Authors: Afriansyah Muhammad Ardi , Budayanti Ni Nyoman Sri , Pinatih Komang Januartha Putra 
Published: April 2020

Background: Escherichia coli belong to the family of Enterobacteriaceae that are responsible as one of the leading cause of nosocomial infections. The emergence of Carbapenem-resistant Enterobacteriaceae presents therapeutic challenges for clinicians on choosing the correct type of antibiotics to prescribe. The Emergence of microorganism capable of producing metallo-Î²-Lactamase (MBL) causes resistance to several antibiotic, including carbapenem.Â Aim: The study aims is to detect whether there are E.coli clinical isolates in Sanglah hospital that produce metallo-Î²-Lactamase (MBL) enzyme and carries blaIMP metallo-Î²-Lactamase (MBL) gene.Methods: Clinical isolates of E.coli were collected from patients diagnosed with infection in Sanglah Hospital within January to June of 2018 nd has been subjected to antibiotics susceptibility test using Vitek-2 Compact system. EDTA-DDST was performed to detect MBL producing strains, followed by detection of blaIMP gene using PCR.Results: There were no E.coli clinical isolates that produce MBL enzyme and carried blaIMP gene (0.0%). The prevalence of E.coli producing blaIMP gene in Sanglah hospital was 0.0%. Â Conclusions: None of the Escherichia coli exhibits the ability to produce metallo-Î²-Lactamase (MBL) enzyme and carried blaIMP gene. Detecting other genes aside from blaIMP gene may be necessary to reveal the other causative factors of antibiotics resistance in Escherichia coli.Â
Water Sport-Related Spine Injury in Bali: A Review and Preliminary Study
Authors: Suyasa I Ketut , Lestari Anak Agung Wiradewi , Prabawa I Putu Yuda , Marta Ketut Kris Adi 
Published: April 2020

Background: Spinal Injury is a devastating injury with life-long impact on an individualâ€™s health and quality of life. SportÂ­ing activities, such as water sport, is also known contributed to the spinal injury. Â This study aims to evaluate the water sport-related spine injury (WS-RSI) which is occurred in Bali during 2017 as a preliminary study at BROS Hospital.Methods: A cross-sectional study was conducted retrospectively among 55 patients who got an injury during water-sport activity in 2017 and admitted to BROS Hospital, Denpasar, Bali by medical records. There was 28 patient-related spine injury. Demographic status regarding age, sex, length of stays, hemoglobin (Hb), random blood glucose, nationality, country origin, treatment, patientâ€™s status, history of alcohol intake, type of water sport, and the location of spine injury were recorded. Data were analyzed using SPSS version 25 for Windows in meanÂ±SD, percentage, and odds ratio (OR) as well as statistically significant if P-value less than 0.05.Results: Indonesian travelers were predominant in WS-RSI (53.6%), followed by China and Australia (17.9%), India, Japan, and European countries (3.6%, respectively). The average age of patients was higher in spine injury (47.89Â±15.98 years; P=0.047). Both sexes were equal (50%). There was no significant difference in Hemoglobin (Hb) (11.08Â±1.30 g/dL) and random blood glucose (100.65Â±21.37 mg/dL) (P>0.05) levels. However, there was a significant difference among nationality, type of treatment, patientâ€™s status, and type of WS-RSI compared with non-spine injury (P<0.05). Based on variables, banana boat, foreign travelers, conservative treatment, and outpatient status were having a higher risk in WS-RSI (OR= 4.275; 5.143; 5.014; 7.389; P<0.05, respectively)Conclusion: As a preliminary study, recent findings at BROS Hospital, Denpasar, Bali suggest that several factors are having a higher risk towards water sport-related spine injuries such as older age, banana boat, foreign travelers, conservative treatment, and outpatient status
Isolasi bakteri Escherichia coli pada lawar merah babi di kota Denpasar
Authors: Yulianto Dennis , Sukrama I Dewa Made , Hendrayana Made Agus 
Published: April 2020

Background: An alarming incidence rate of food-borne diseases in Indonesia become more worrible, especially the one which is caused by Escherichia coli. Based on Food and Drug Supervisory Agency or Badan Pengawas Obat dan Makanan (BPOM) in Indonesia, there are 18.144 people who got infected by food-borne illnesses in 2011. These facts are quite alarming for the people who live in Bali and they are more likely to consume lawar merah babi.Â Lawar merah babi is a traditional Balinese food made from the mix of vegetable, meat, and some other ingredients as well as it is usually mixed by hand which make it susceptible to be contaminated by bacteria such as Escherichia coli. Aim: The study aims to investigate the E. coli contamination within lawar merah in Denpasar. Method: This descriptive cross-sectional study was conducted using 12 samples of lawar merah babi which were sold in 12 different places all across the Denpasar City. These samples were taken to Microbiology Laboratorium at Medical Faculty, Udayana University. There are three variants of dilution for each sample which are 10-1, 10-2, and 10-3. Each sample was cultured using eosin methylene blue agar as the media. Some of the sample without clear representation in the media will go through further identification. The results of Escherichia coli colonization were counted by the total plating count method to produce them in CFU/g for each of the samples.Result: Some of the samples have been contaminated by Escherichia coli (67%) approximately 17x104 CFU/g contamination average level.Conclusion: The samples exceed the contamination limit which is permitted by the BPOM recommendation, where the maximum Escherichia coli contamination level should not exceed over than 3 CFU/g.
Perbedaan parameter analisa gas darah (AGD) pada mixing sampel sesuai dan tidak sesuai standar Clinical and Laboratory Standards Institute (CLSI)
Authors: Kusuma Diah Ayu , Rachmawati Banundari 
Published: April 2020

Pendahuluan: Analisis Gas Darah (AGD) merupakan bagian penting untuk mendiagnosis dan mengelola status oksigenasi dan keseimbangan asam basa pasien. Instalasi Gawat Darurat (IGD) dan perawatan intensif (ICU) menggunakan AGD sebagai bagian tak terpisahkan dari penilaian status klinis pasien. Dalam pemeriksaan AGD khususnya, pengumpulan dan penanganan spesimen darah arteri yang tidak tepat dapat menghasilkan hasil yang keliru. Pada pemeriksaan AGD salah satu kesalahan pra-analitik adalah mixing sampel yang tidak sesuai standar. Tujuan penelitian ini adalah membuktikan adanya perbedaan hasil parameter AGD antara sampel yang dilakukan mixing sesuai dengan standar Clinical and Laboratory Standards Institute (CLSI) dan yang tidak sesuai standar CLSI.Metode: Ini merupakan studi observasional analitik potong lintang. Subjek penelitian adalah pasien usia 25-50 tahun yang dirawat di ICU RSUP Dr. Kariadi Semarang dan dilakukan pemeriksaan AGD. Analisis statistik menggunakan paired T-test dan Wilcoxon test. Dikatakan terdapat perbedaan bermakna apabila nilai p < 0.05.Hasil: Terdapat perbedaan bermakna pada parameter pO2 (p < 0.001), SO2 (p Â Â Â Â Â < 0.001), Â dan natrium (p = 0.038) antara sampel yang dilakukan mixing sesuai standar CLSI dan tidak sesuai standar CLSI. Tidak terdapat perbedaan bermakna pada parameter pH, pCO2, Hb, Hct, HCO3-, dan BE antara sampel yang dilakukan mixing sesuai standar CLSI dan tidak sesuai standar CLSI.Simpulan: Terdapat perbedaan bermakna pada parameter untuk menilai status oksigenasi antara mixing sampel sesuai dengan CLSI dan tidak sesuai CLSI. Mixing sampel yang benar diperlukan untuk mendapatkan hasil yang dapat dipertanggungjawabkan.
Hubungan jenis packed red cell (PRC) yang ditransfusikan dengan reaksi transfusi febrile non haemolytic transfusion reaction (FNHTR)
Authors: Kamilah Dinda , Widyaningrum Dian 
Published: April 2020

Background: One of the components of blood cells are often used for transfusions is Packed Red Cell (PRC). Blood components transfusion may continues with rapid or delayed transfusion ractions. The most transfusion reactionsÂ was fever (55%) or febrile non haemolytic transfusion reaction (FNHTRs). The cause of these events is associated with allogenic leucocytes (the ability to differentiate self cells and non-self cells based on the human leukocyte antigen (HLA) on the cell surface) and release of proinflammatory cytokines such as IL-1, IL-6, IL-8, TNFÎ±, Cell-free DNA (cfDNA), histone and the duration of blood storage. Methods: Cross-sectional study on 41.177 patients who received a PRC transfusion with the FNHTR transfusion reaction in Hospital Blood Bank Dr. Kariadi Semarang, duringÂ January 2017 to July 2018. Pearson Chi Square test for expected frequency more than 5. The Kolmogorov smirnov and Shapiro-wilk test were used to evaluate normality of the data. Mann-Whitney test to analyze the difference, p < 0,05 was considered as significant.Results: The incidence of FNHTR was lower in patients who received leukodepleted PRC (11 patients) than non leukodepleted PRC (124 patients). There were differences in body temperature in the incidence of FNHTR between the two groups 38.10 C (38-39) VS 38.40 C (38 â€“ 39.2) with p = 0,046.Conclusions:There were relationship between the incidence of FNHTR with the transfusion with leukodepleted PRC and non leukodepleted PRC.
Hubungan kadar leptin terhadap parameter trombosit pada pasien dengan obesitas
Authors: Fajaryani Dwi , Hendrianingtyas Meita , Retnoningrum Dwi 
Published: April 2020

Background: Obesity is excessive and abnormal fat accumulation thus harmful to health. Increase in body mass index (BMI) in obesity, also accompanied by increase hormon which synthesized and released by adipose tissue informs the brain for controlling hunger and food intake that is Leptin. Leptin plays a role in chronic inflammatory process of obesity. Leptin receptor was detected in human platelets and high concentration of leptin reported to promote platelet aggregation. The platelet parameters examination is a cheap, easy, and routinly done in daily basis, which consist of platelet counts, mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), plateletcrit (PCT), which indicates platelet proliferation. The aim of research was to look the relationship of leptin with thrombocyte parameter in obesity people.Methods: Cross sectional study of 45 obese adults, based on RISKESDAS criteria Â with Â BMI>27, on Mei-September 2018 was done. Venous blood collected in EDTA and plain tube. The EDTA sample was used for complete hematological examination to obtain platelet parameters by Hematology analayzer with impendace method. Serum from plain tube used for leptin examination was measured by ELISA. Data were analyzed by Pearson and Spearman correlation test. P-value < 0,05 was consideres as significant.Results: There is no correlation between leptin and platelet count (r=0,051, p=0,740), MPV (r=0,021, p=0,891), PDW (r=-0,093, p=0,541),Â P-LCR (r=0,082,Â p=0,593), and PCTÂ (r=0,079, p=0,605).Â Conclusion: There is no correlation between leptin and platelet parameters in obesity. Further studies need to be done with adding another characteristic such as inflammation markers, metabolic syndrome parameters and platelet activation
Faktor risiko yang mempengaruhi length of stay pasien kanker solid dengan febrile neutropenia pasca kemoterapi neoadjuvant/terapeutik di Ruang Isolasi RSUP Sanglah, Bali
Authors: Natawidjaja Ronald , Manuaba Ida Bagus Tjakra Wibawa , Adiputra Putu Anda Tusta 
Published: April 2020

Background. Febrile neutropenia is a common complication in patient undergoing chemotherapy. Length Of Stay (LOS) is an important marker for disease severity and use of medical resources in febrile neutropenia. This study was done to find the risk factor affecting length of stay in solid cancer patients with febrile neutropenia post neoadjuvant/therapeutic chemotherapy.Method. This is a case control study without matching. Age â‰¥ 60 years, (Absolute Neutrofil Count) ANC level < 1,5 Î¼L , comorbid,Â Hb level <10 gr/dl, and albumin < 3 gr/dl, were related to LOS ( â‰¤ 5 days and > 5 days). Univariate (chi square) and multivariate (logistic regression) were used to analyse the statistic.Results. Forty six patients met inclusion-exclusion criteria were included in this study. ANC level in all patients were < 1,5 Î¼L (100%). Hb level <10 gr/dl is statistically significant (P<0.05), whereasÂ age â‰¥ 60 years, and comorbid, albumin level < 3 gr/dl were not is statistically significant (P>0.05).Conclusion. Hb level < 10 gr/dl is the risk factor for LOS > 5 days in solid cancer patients with febrile neutropenia post neoadjuvant/therapeutic chemotherapy.
The correlation between demography and clinical status based on WHO staging in MSM HIV patients at Bali Medical Centre
Authors: Nair Dhanesh Sukumar , Sutarsa I Nyoman , Sawitri A A Sagung , Kartika Sari Komang Ayu 
Published: April 2020

Background: HIV stands for human immunodeficiency virus which is in the category of lentivirus (a subgroup of retrovirus) that causes HIV infection and can lead to acquired immunodeficiency syndrome (AIDS).Â HIV affects specific cells of the immune system, called CD4 cells, or T cells. Over time, if left untreated, HIV can destroy so many of these cells that the body would not be able to fight off infections and disease. However, with proper medical care, HIV can be controlled. Treatment for HIV is called antiretroviral therapy (ART). It involves taking a combination of HIV medicines (called an HIV regimen) every day. Today, a person who diagnosed with HIV before the disease is far advanced and who gets and stays on ART can live a nearly normal lifespan.Aim: This study aims to investigate and analyze the predictors that influence WHO staging of homosexual MSM HIV patients treated at the BMC hospital in Bali. Indonesia, and to determine the factors that lead to differences in the WHO staging in MSM patients with HIV.Method: This study used a retrospective cohort method using secondary data from BMC Hospital. The sample population for this research is MSM HIV patients treated at the BMC hospital in Bali. Using the total sampling method yielded 271 samples.Result and Conclusion: the HIV incidence is a serious matter in Indonesia. One of the underlying factors for the delayed diagnosis of HIV is the lack of knowledge about the improved prognosis of early ARV treatment and a fear of being stigmatized by the community. Increased availability of HIV testing at hospitals, combined with enhanced knowledge of the prognosis of HIV treatment among crucial affected population, and the community at large and may improve earlier testing.
Karakteristik ibu hamil dengan hiperemesis gravidarum di RSUP Sanglah Denpasar tahun 2017
Authors: Putri Luh Putu Mahatya Valdini , Wiradnyana A. A. Gede Putra , Darmayasa I Made 
Published: April 2020

Background: Hyperemesis gravidarum is severe and over vomiting suffered as of early in pregnancy until 20 weeks of gestation. It may be harmful to the mother's health that can lead to weight loss of more than 5% and cause metabolic disorders. If it does not get proper treatment, it affects complications, even maternal and fetal deaths.Aim: The study aims to generalize the characteristic of pregnant patients who suffered hyperemesis gravidarum in Sanglah General Hospital.Method: This study is a cross sectional retrospective descriptive study with data retrieval on patient records for one year in 2017. This research was conducted at Space Cempaka Obstetrics and Medical Record Division Sanglah Hospital Denpasar.Result and Conclusion: pregnant women with hyperemesis gravidarum based on motherâ€™s age is highest experienced by pregnant women in the age group 20-35 years as many as 6 people (75%). Based on maternal age, pregnant women with hyperemesis gravidarum is highest experienced by pregnant women in the first trimester as many as 5 people (62.5%). As regard with the parity, Â it was highest experienced by pregnant women in the parity group nullipara as many as 4 people (50%). Moreover, maternal education is highest academic of pregnant women who have junior high and high school education, each of them as many as 3 people (37.5%). Based on the job status is highest experienced by pregnant women who work as many as 5 people (62.5%).