bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution and Ecology in Widespread Acoustic Signaling Behavior Across Fishes
Authors: Rice Aaron N. , Farina Stacy C. , Makowski Andrea J. , Kaatz Ingrid M. , Lobel Philip S. , Bemis William E. , Bass Andrew H. 
Published: September 2020

AbstractAcoustic signaling by fishes has been recognized for millennia, but is typically regarded as comparatively rare within ray-finned fishes; as such, it has yet to be integrated into broader concepts of vertebrate evolution. We map the most comprehensive data set of volitional sound production of ray-finned fishes (Actinopterygii) yet assembled onto a family level phylogeny of the group, a clade representing more than half of extant vertebrate species. Our choice of family-level rather than species-level analysis allows broad investigation of sonifery within actinopterygians and provides a conservative estimate of the distribution and ancestry of a character that is likely far more widespread than currently known. The results show that families with members exhibiting soniferous behavior contain nearly two-thirds of actinopterygian species, with potentially more than 20,000 species using acoustic communication. Sonic fish families also contain more extant species than those without sounds. Evolutionary analysis shows that sound production is an ancient behavior because it is present in a clade that originating circa 340 Ma, much earlier than any evidence for sound production within tetrapods. Ancestral state reconstruction indicates that sound production is not ancestral for actinopterygians; instead, it independently evolved at least 27 times, compared to six within tetrapods. This likely represents an underestimate for actinopterygians that will change as sonifery is recognized in ever more species of actinopterygians. Several important ecological factors are significantly correlated with sonifery – including physical attributes of the environment, predation by members of other vertebrate clades, and reproductive tactics – further demonstrating the broader importance of sound production in the life history evolution of fishes. These findings offer a new perspective on the role of sound production and acousticcommunication during the evolution of Actinopterygii, a clade containing more than 34,000 species of extant vertebrates.
Time-restricted feeding prolongs lifespan inDrosophilain a peripheral clock-dependent manner
Authors: Cabrera Daniel , Young Michael W. , Axelrod Sofia 
Published: September 2020

AbstractTime-restricted feeding/eating (TRF/TRE) – limiting not the amount of food but the daily time window of food intake – is a dietary intervention that has been shown to improve health markers in model organisms and humans, but whether these benefits translate into positive effects on aging and longevity is not clear. We demonstrate here that TRF robustly prolongs lifespan in the short-lived genetically tractable model organismDrosophila melanogaster. Median TRF lifespan extensions range between ∼10% and ∼50% dependent on sex, reproductive status, TRF duration, and genotype. TRF’s positive effect on longevity is independent of food intake and at least in part relies on a functioning circadian clock: TRF benefits on longevity are abolished in arrhythmicper0andtim01mutants as well as in constant light, suggesting that timed feeding acts as a zeitgeber partitioning eating and associated metabolic processes into certain phases of day and night. TRF-mediated longevity extension is unaffected in flies whose neural circadian clocks have been abolished genetically, pointing towards peripheral clocks as the target of TRF mediating lifespan extension.
Phylogenomics reveals multiple introductions and early spread of SARS-CoV-2 into Peru
Authors: Juscamayta-López Eduardo , Tarazona David , Valdivia Faviola , Rojas Nancy , Carhuaricra Dennis , Maturrano Lenin , Gavilán Ronnie 
Published: September 2020

ABSTRACTPeru has become one of the countries with the highest mortality rate from the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To investigate early transmission event and genomic diversity of SARS-CoV-2 isolates circulating in Peru, we analyzed a total of 3472 SARS-CoV-2 genomes, from which 149 ones were from Peru. Phylogenomic analysis revealed multiple and independent introductions of the virus mainly from Europe and Asia. In addition, we found evidence for community-driven transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different Peru regions.
Intracellular Optical Doppler Phenotypes of Chemosensitivity in Human Epithelial Ovarian Cancer
Authors: Li Zhe , An Ran , Swetzig Wendy M. , Kanis Margaux , Nwani Nkechiyere , Turek John , Matei Daniela , Nolte David 
Published: September 2020

AbstractDevelopment of an assay to predict response to chemotherapy has remained an elusive goal in cancer research. We report a phenotypic chemosensitivity assay for epithelial ovarian cancer based on Doppler spectroscopy of infrared light scattered from intracellular motions in living three-dimensional tumor biopsy tissue measuredin vitro. The study analyzed biospecimens from 20 human patients with epithelial ovarian cancer. Matched primary and metastatic tumor tissues were collected for 3 patients, and an additional 3 patients provided only metastatic tissues. Doppler fluctuation spectra were obtained using full-field optical coherence tomography through off-axis digital holography. Frequencies in the range from 10 mHz to 10 Hz are sensitive to changes in intracellular dynamics caused by platinum-based chemotherapy. Metastatic tumor tissues were found to display a biodynamic phenotype that was similar to primary tissue from patients who had poor clinical outcomes. The biodynamic phenotypic profile correctly classified 90% [88% to 91% c.i.] of the patients when the metastatic samples were characterized as having a chemoresistant phenotype. This work suggests that Doppler profiling of tissue response to chemotherapy has the potential to predict patient clinical outcomes based on primary, but not metastatic, tumor tissue.
Six Sigma quality evaluation of life test data based on Weibull distribution
Authors: A Niveditha , Joghee Ravichandran 
Published: September 2020

PurposeWhile Six Sigma metrics have been studied by researchers in detail for normal distribution-based data, in this paper, we have attempted to study the Six Sigma metrics for two-parameter Weibull distribution that is useful in many life test data analyses.Design/methodology/approachIn the theory of Six Sigma, most of the processes are assumed normal and Six Sigma metrics are determined for such a process of interest. In reliability studies non-normal distributions are more appropriate for life tests. In this paper, a theoretical procedure is developed for determining Six Sigma metrics when the underlying process follows two-parameter Weibull distribution. Numerical evaluations are also considered to study the proposed method.FindingsIn this paper, by matching the probabilities under different normal process-based sigma quality levels (SQLs), we first determined the Six Sigma specification limits (Lower and Upper Six Sigma Limits- LSSL and USSL) for the two-parameter Weibull distribution by setting different values for the shape parameter and the scaling parameter. Then, the lower SQL (LSQL) and upper SQL (USQL) values are obtained for the Weibull distribution with centered and shifted cases. We presented numerical results for Six Sigma metrics of Weibull distribution with different parameter settings. We also simulated a set of 1,000 values from this Weibull distribution for both centered and shifted cases to evaluate the Six Sigma performance metrics. It is found that the SQLs under two-parameter Weibull distribution are slightly lesser than those when the process is assumed normal.Originality/valueThe theoretical approach proposed for determining Six Sigma metrics for Weibull distribution is new to the Six Sigma Quality practitioners who commonly deal with normal process or normal approximation to non-normal processes. The procedure developed here is, in fact, used to first determine LSSL and USSL followed by which LSQL and USQL are obtained. This in turn has helped to compute the Six Sigma metrics such as defects per million opportunities (DPMOs) and the parts that are extremely good per million opportunities (EGPMOs) under two-parameter Weibull distribution for lower-the-better (LTB) and higher-the-better (HTB) quality characteristics. We believe that this approach is quite new to the practitioners, and it is not only useful to the practitioners but will also serve to motivate the researchers to do more work in this field of research.
Franchising in Brazil: foreign entrants build a presence
Authors: Bretas Vanessa Pilla Galetti , Alon Ilan 
Published: September 2020

Purpose
The purpose of this paper is to provide an overview of the franchising sector in Brazil and highlight the opportunities and offer strategies for practitioners. It also points out some challenges and gives suggestions to overcome them and thrive in the Brazilian market through the franchising system.

Design/methodology/approach
This paper reviews both literature and practical sources providing primary data from interviews conducted with franchising experts from the Brazilian Franchising Association and a consultant company.

Findings
International franchisors willing to enter the Brazilian market might face some challenges, such as the language barrier, the complex tax system and the need for local adaptations. Foreign entrants should consider low control entry modes as master franchising and area development agreements, with local partners that know the Brazilian culture, business system and regulations.

Originality/value
Brazil presents a great market potential for international franchisors. It counts with an established franchising system and a stable regulatory environment. This paper provides relevant information about the characteristics, opportunities and challenges to operate in the Brazilian market, offering suggestions of strategies and several possibilities to explore different regions, locations and models across the country.
Study on the Influence of Inlet Asymmetry on Aerodynamic Noise of Cooling Fan
Authors: Tian Jie , Sun Zonghan , Chai Pengfei , Ouyang Hua 
Published: September 2020

Abstract
Experimental and numerical studies on the aerodynamic noise characteristics of a variable-speed axial fan commonly used for electronic device heat dissipation were conducted. First, the far-field noise spectrum of the fan was measured using a microphone on the contour plane of the fan axis. The spectral analysis indicated that the discrete single-tone noise energy ratio was high, which indicates that it was the dominant aerodynamic noise. Afterward, the double-uniform sampling point mode correction technique, which is based on the circumferential acoustic mode measurement method, was used to obtain the modal distribution on the inlet and outlet sides of the cooling fan. The influence of inlet unevenness on the cooling fan was identified. The traditional Tyler–Sofrin rotor–stator interaction formula was modified to account for the nonaxisymmetric shape of the fan inlet bellmouth. The validity of the modified formula was verified by measuring the circumferential acoustic modes of three cooling fans with different rotor and strut counts. Furthermore, a computational fluid dynamics (CFD) numerical study was conducted using Fluent to understand the influence of uneven inlet flow. The results showed that uneven inlet flow significantly affects the size and distribution of unsteady pulses on the rotor blades, which cause regular, periodic changes as the rotor blades rotate. Interactions between rotor blades and inlet unevenness were observed via the proper orthogonal decomposition (POD) method as well. The discussion of the circumferential modes from aerodynamic noise of an axial flow cooling fan can act as a reference for further cooling fan noise reduction measures.
Manufacturing of Nanocomposites via Powder Injection Molding: Focusing on Thermal Management Systems—A Review
Authors: Hosseinpour Maryam , Abdoos Hassan 
Published: September 2020

AbstractThe rapid evolution of electronic and information technology has increased the performance of the electronic processors significantly. Achieving the optimal performance in a smart electronic device poses a serious challenge as the heat generated during operation will reduce the performance of the device which makes thermal management a determinant factor. Powder injection molding (PIM) is an appropriate and relatively new technology used for mass production of small delicate parts with complex shapes and desired properties. One of the latest advances in the PIM process is the production of metal matrix nanocomposites with huge industrial applications, particularly in electronics manufacturing. Manufacturing of efficient complex-shaped nanocomposites, as thermal management components (passive heatsink), could be achieved through the PIM process. On the other hand, what could pose a challenge is the presence of nanoparticles affecting on the different stages of PIM process including feedstock preparation, molding, debinding, and sintering. In this paper, the effect of nanoparticles on different stages of PIM for the production of heatsinks is investigated. Then, the manufacturing of Cu-, Al-, and Mg-based nanocomposites by powder injection molding, as heatsinks, is reviewed followed by investigating the related advantages and limitations.
Postexercise Inflammasome Activation and IL-1β Production Mitigated by Flavonoid Supplementation in Cyclists
Authors: Nieman David C. , Ferrara Francesca , Pecorelli Alessandra , Woodby Brittany , Hoyle Andrew T. , Simonson Andrew , Valacchi Giuseppe 
Published: September 2020

Inflammasomes are multiprotein signaling platforms of the innate immune system that detect markers of physiological stress and promote the maturation of caspase-1 and interleukin 1 beta (IL-1β), IL-18, and gasdermin D. This randomized, cross-over trial investigated the influence of 2-week mixed flavonoid (FLAV) versus placebo (PL) supplementation on inflammasome activation and IL-1β and IL-18 production after 75-km cycling in 22 cyclists (42 ± 1.7 years). Blood samples were collected before and after the 2-week supplementation, and then 0 hr, 1.5 hr, and 21 hr postexercise (176 ± 5.4 min, 73.4 ± 2.0 %VO2max). The supplement (678 mg FLAVs) included quercetin, green tea catechins, and bilberry anthocyanins. The pattern of change in the plasma levels of the inflammasome adaptor oligomer ASC (apoptosis-associated speck-like protein containing caspase recruitment domain) was different between the FLAV and PL trials, with the FLAV ASC levels 52% lower (Cohen’s d = 1.06) than PL immediately following 75-km cycling (interaction effect, p = .012). The plasma IL-1β levels in FLAV were significantly lower than PL (23–42%; Cohen’s d = 0.293–0.644) throughout 21 hr of recovery (interaction effect, p = .004). The change in plasma gasdermin D levels were lower immediately postexercise in FLAV versus PL (15% contrast, p = .023; Cohen’s d = 0.450). The patterns of change in plasma IL-18 and IL-37 did not differ between the FLAV and PL trials (interaction effects, p = .388, .716, respectively). These data indicate that 2-week FLAV ingestion mitigated inflammasome activation, with a corresponding decrease in IL-1β release in cyclists after a 75-km cycling time trial. The data from this study support the strategy of ingesting high amounts of FLAV to mitigate postexercise inflammation.
Caffeinated Chewing Gum Improves Bicycle Motocross Time-Trial Performance
Authors: Daneshfar Amin , Petersen Carl J. , Koozehchian Majid S. , Gahreman Daniel E. 
Published: September 2020

This study aimed to identify the acute effects of caffeinated chewing gum (CAF) on bicycle motocross (BMX) time-trial (TT) performance. In a randomized, placebo-controlled, double-blind cross-over design, 14 male BMX riders (age = 20.0 ± 3.3 years; height = 1.78 ± 0.04 m; body mass = 72 ± 4 kg), consumed either (300 mg; 4.2 ± 0.2 mg/kg) caffeinated (300 mg caffeine, 6 g sugars) or a placebo (0 mg caffeine, 0 g sugars) gum, and undertook three BMX TTs. Repeated-measure analysis revealed that CAF has a large ergogenic effect on TT time, F(1, 14) = 33.570, p = .001, ; −1.5% ± 0.4 compared with the placebo. Peak power and maximal power to weight ratio also increased significantly compared with the placebo condition, F(1, 14) = 54.666, p = .001, ; +3.5% ± 0.6, and F(1, 14) = 57.399, p = .001, ; +3% ± 0.3, respectively. Rating of perceived exertion was significantly lower F(1, 14) = 25.020, p = .001, in CAF (6.6 ± 1.3) compared with the placebo (7.2 ± 1.7). Administering a moderate dose (300 mg) of CAF could improve TT time by enhancing power and reducing the perception of exertion. BMX coaches and riders may consider consuming CAF before a BMX race to improve performance and reduce rating of perceived exertion.
Role of brain tissue oxygenation (PbtO2) in the management of subarachnoid haemorrhage: a scoping review protocol
Authors: Fiore Marco , Bogossian Elisa , Creteur Jacques , Oddo Mauro , Taccone Fabio Silvio 
Published: September 2020

IntroductionIn patients with subarachnoid haemorrhage (SAH), the initial brain oedema and increased blood volume can cause an increase in intracranial pressure (ICP) leading to impaired cerebral perfusion and tissue hypoxia. However, ICP monitoring may not be enough to detect tissue hypoxia, which can also occur in the absence of elevated ICP. Moreover, some patients will experience tissue hypoxia in a later phase after admission due to the occurrence of delayed cerebral ischaemia. Therefore, the measurement of brain oxygenation using invasive techniques has become of great interest. This scoping review seeks to examine the role of brain tissue oxygenation in the management of patients with SAH, mapping the existing literature to identify areas for future research.Methods and analysisThis scoping review has been planned following the Joanna Briggs Institute recommendations and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The literature search will be performed using several databases: Medline, EMBASE, the Cochrane Central Register of Controlled Trials and Grey literature. The database searches are planned from the inception to May 2020. Two reviewers will independently screen titles and abstracts, followed by full-text screening of potentially relevant articles with a standardised data extraction. Articles eligible for the inclusion will be discussed with a third reviewer.Ethics and disseminationThis paper does not require ethics approval. The results of our evaluation will be disseminated on author’s web sites. Additional dissemination will occur through presentations at conferences, such as courses and science education conferences, regionally and nationally, and through articles published in peer-reviewed journals.Scoping review registrationOpen Science Framework Registration: https://doi.org/10.17605/OSF.IO/ZYJ7R.Trial registration numberClinicalTrials.gov Identifier: NCT03754114.
Perioperative management for people with chronic kidney disease receiving dialysis undergoing major surgery: a protocol for a scoping review
Authors: Harrison Tyrone G , Hemmelgarn Brenda R , Farragher Janine F , O'Rielly Connor , Donald Maoliosa , James Matthew , McCaughey Deirdre , Ruzycki Shannon M , Zarnke Kelly B , Ronksley Paul E 
Published: September 2020

IntroductionPeople with chronic kidney disease receiving dialysis (CKD G5D) have an increased risk of poor postoperative outcomes and a high incidence of major surgery. Despite the high burden of these combined risks, there is a paucity of evidence to support tailored perioperative strategies to manage this population. A comprehensive evidence synthesis would inform the management of these patients in the perioperative period and identify knowledge gaps. We describe a protocol for a scoping review of the literature to identify existing perioperative strategies, protocols, pathways and interventions for people with CKD G5D undergoing major surgery.Methods and analysisWe will conduct a scoping review in accordance with the Joanna Briggs Institute methodology and report per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews. In February 2020, we will complete our search of MEDLINE, EMBASE, CINAHL Plus, Cochrane Database of Systematic Reviews, and Cochrane Controlled Trials Registry for published literature from inception to present. All study types are eligible for inclusion, without language restriction. Studies reporting a perioperative intervention in adult patients with CKD G5D are eligible for inclusion. Studies in prevalent kidney transplant patients or patients with acute kidney injury, and studies that report on surgical approaches without consideration of perioperative management strategies, will be excluded. Reviewers will independently assess abstracts for all identified studies in duplicate, and again at the full-text stage. Following published literature searches, a search of the grey literature will be developed. We will extract and narratively report study, participant and intervention details. This will include a summary table outlining the strategies employed, organised into post hoc developed perioperative domains.Ethics and disseminationEthical considerations do not apply to this scoping review. Findings will be disseminated through relevant conference presentations and publications.
Clinical and genomic characterisation of mismatch repair deficient pancreatic adenocarcinoma
Authors: Grant Robert C , Denroche Robert , Jang Gun Ho , Nowak Klaudia M , Zhang Amy , Borgida Ayelet , Holter Spring , Topham James T , Wilson Julie , Dodd Anna , Jang Raymond , Prince Rebecca , Karasinska Joanna M , Schaeffer David F , Wang Yifan , Zogopoulos George , Berry Scott , Simeone Diane , Renouf Daniel J , Notta Faiyaz , O'Kane Grainne , Knox Jennifer , Fischer Sandra , Gallinger Steven 
Published: September 2020

ObjectiveTo describe the clinical, pathological and genomic characteristics of pancreatic cancer with DNA mismatch repair deficiency (MMRD) and proficiency (MMRP).DesignWe identified patients with MMRD and MMRP pancreatic cancer in a clinical cohort (N=1213, 519 with genetic testing, 53 with immunohistochemistry (IHC)) and a genomic cohort (N=288 with whole-genome sequencing (WGS)).Results12 out of 1213 (1.0%) in the clinical cohort were MMRD by IHC or WGS. Of the 14 patients with Lynch syndrome, 3 (21.4%) had an MMRP pancreatic cancer by IHC, and 4 (28.6%) were excluded because tissue was unavailable for testing. MMRD cancers had longer overall survival after surgery (weighted HR after coarsened exact matching 0.11, 95% CI 0.02 to 0.78, p=0.001). One patient with an unresectable MMRD cancer has an ongoing partial response 3 years after starting treatment with PD-L1/CTLA-4 inhibition. This tumour showed none of the classical histopathological features of MMRD. 9 out of 288 (3.1%) tumours with WGS were MMRD. Despite markedly higher tumour mutational burden and neoantigen loads, MMRD cancers were significantly less likely to have mutations in usual pancreatic cancer driver genes like KRAS and SMAD4, but more likely to have mutations in genes that drive cancers with microsatellite instability like ACV2RA and JAK1. MMRD tumours were significantly more likely to have a basal-like transcriptional programme and elevated transcriptional markers of immunogenicity.ConclusionsMMRD pancreatic cancers have distinct clinical, pathological and genomic profiles. Patients with MMRD pancreatic cancer should be considered for basket trials targeting enhanced immunogenicity or the unique genomic drivers in these malignancies.