bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Robust and High Self‐Healing Efficiency Poly(Urea‐Urethane) Based on Disulfide Bonds with Cost‐Effective Strategy
Authors: Wang Yulong , Li Yaqiong , Bai Jingjing , Li Zhenzhong , Hu Guosheng 
Published: October 2019

AbstractThe development of self‐healing poly(urea‐urethane)s with remarkable mechanical properties as well as self‐healing capability is an important challenge through a low‐cost approach. In this study, cystine dimethyl ester (CDE) is synthesized cost‐effectively using cystine from bio‐based sources as raw material, and a novel self‐healing poly(urea‐urethane) is successfully prepared using synthesized CDE as a disulfide‐containing chain extender through a two‐step approach. The as‐prepared disulfide‐containing poly(urea‐urethane) (SPU) presents an excellent self‐healing capability with self‐healing efficiency of 95.3% at a moderate healing temperature (≈60 °C). Meanwhile, the SPU exhibits robust mechanical properties possessing a maximum tensile strength of 25.80 MPa and a high elongation at break of over 460% simultaneously. The compromise between self‐healing capability and mechanical performance can be responsible for the exchange of dynamic disulfide bonds and the existence of quadruple hydrogen bonding. This strategy provides an available idea to develop robust self‐healing polymer materials cost‐effectively.
Superconvergent patch recovery with constraints for three‐dimensional contact problems within the Cartesian grid Finite Element Method
Authors: Navarro‐Jiménez José M. , Navarro‐García Héctor , Tur Manuel , Ródenas Juan J. 
Published: October 2019

SummaryThe superconvergent patch recovery technique with constraints (SPR‐C) consists in improving the accuracy of the recovered stresses obtained with the original SPR technique by considering known information about the exact solution, like the internal equilibrium equation, the compatibility equation or the Neumann boundary conditions, during the recovery process. In this paper the SPR‐C is extended to consider the equilibrium around the contact area when solving contact problems with the Cartesian grid Finite Element Method. In the proposed method, the Finite Element stress fields of both bodies in contact are considered during the recovery process and the equilibrium is enforced by means of the continuity of tractions along the contact surface.
Synthesis and Properties of Polycarbosilanes Having Lactose‐Derived Structures
Authors: Matsumoto Kozo , Miyano Tatsuya , Kotake Yojiro 
Published: October 2019

ABSTRACTA polycarbosilane having lactose‐derived structures was synthesized, and its thermal property, cytotoxicity, chemical crosslinking, and protein adsorption properties were investigated. The polycarbosilane (PSB‐Lac) was prepared by a thiol‐ene reaction between precursor poly(1‐(3‐butenyl)‐1‐methylsilacyclubane) (PSB) and heptaacetyl lactose that carried a thiol group at the anomeric position, and the successive deprotection of the acetyl groups. The lactose introduction efficiency determined by 1H NMR measurement was 75%. TGA and DSC revealed that the polymer had a 5 wt% decomposition temperature of 260 °C and glass transition temperature (Tg) of 84 °C, which indicated that PSB‐Lac was a thermally stable polymer. PSB‐Lac had no significant cytotoxicity, which was evaluated by human liver cancer cell line HepG2 cultivation on the polystyrene dishes coated with the polymer. Urethane‐crosslinked PSB‐Lac films were prepared by casting solutions of PSB‐Lac and hexamethylene diisocyanate and heating at 120 °C after evaporation of the solvent. The crosslinked PSB‐Lac showed higher adsorption of bovine serum albumin than the similarly crosslinked polycarbosilane that had a glucose structure (PSB‐Glc). © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2420–2425
Predictions of Pattern Formation in Amino Acid Adlayers at the In Vacuo Graphene Interface: Influence of Termination State
Authors: Awuah Joel B. , Walsh Tiffany R. 
Published: October 2019

AbstractControlled self‐assembly of biomolecules on graphene offers a pathway for realizing its full potential in biological applications. Microscopy has revealed the self‐assembly of amino acid adlayers into dimer rows on nonreactive substrates. However, neither the spontaneous formation of these patterns, nor the influence of amino acid termination state on the formation of patterns has been directly resolved to date. Molecular dynamics simulations, with the ability to reveal atomic level details and exert full control over the termination state, are used here to model initially disordered adlayers of neutral, zwitterionic, and neutral–zwitterionic mixtures for two types of amino acids, tryptophan and methionine, adsorbed on graphene in vacuo. The simulations of the zwitterion‐containing adlayers exhibit the spontaneous emergence of dimer row ordering, mediated by charge‐driven intermolecular interactions. In contrast, adlayers containing only neutral species do not assemble into ordered patterns. It is also found that the presence of trace amounts of water reduces the interamino acid interactions in the adlayers, but does not induce or disrupt pattern formation. Overall, the findings reveal the balance between the lateral interamino acid interactions and amino acid–graphene interactions, providing foundational insights for ultimately realizing the predictable pattern formation of biomolecules adsorbed on unreactive surfaces.
Trends in mental health, non‐suicidal self‐harm and suicide attempts in 16–24-year old students and non-students in England, 2000–2014
Authors: McManus S. , Gunnell D. 
Published: October 2019

Abstract

There are concerns about high levels of mental ill-health amongst university students, but little is known about the mental health of students compared to non-students over time. Using data on young people (16–24) from three UK National Psychiatric Morbidity Surveys (2000, 2007, and 2014), we found no evidence that the overall prevalence of common mental disorder (CMD), suicide attempts, or non-suicidal self-harm (NSSH) differed between students and non-students, although there was an indication that CMDs rose markedly in female students between 2007 and 2014. A rise in NSSH is apparent in both students and non-students.
The prognostic value of serum erythropoietin in patients with lower-risk myelodysplastic syndromes: a review of the literature and expert opinion
Authors: Park Sophie , Kelaidi Charikleia , Meunier Mathieu , Casadevall Nicole , Gerds Aaron T. , Platzbecker Uwe 
Published: October 2019

AbstractMyelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies associated with an erythroid maturation defect, resulting in anemia. Treatments for MDS include erythropoiesis-stimulating agents (ESAs). The identification of prognostic markers is important to help predict response and improve outcomes. Various scoring systems have been developed to help predict response to ESAs. Despite limitations in its assessment, serum erythropoietin (sEPO) level is an important predictor of hematologic response to ESAs in patients with lower-risk MDS. Numerous studies have reported significantly lower sEPO levels among responders versus non-responders. Furthermore, treatment response is significantly more likely among those with sEPO levels below versus those above various cutoffs. Other prognostic indicators for response to ESAs include lower transfusion requirement, fewer bone marrow blasts, higher hemoglobin, lower serum ferritin, lower-risk MDS, and more normal cytogenetics. Studies of other MDS therapies (e.g., lenalidomide and luspatercept) have also reported that lower sEPO levels are indicative of hematologic response. In addition, lower sEPO levels (up to 500 IU/L) have been included in treatment algorithms for patients with lower-risk MDS to define whether ESAs are indicated. Lower sEPO levels are predictive of hematologic response—particularly to ESAs. Further, clinical trials should use sEPO thresholds to ensure more homogeneous cohorts.
Efficacy and safety of kaolin-based hemostatic pad vs. standard mechanical compression following transradial and transulnar access for elective coronary angiography and PCI: RAUL trial substudy
Authors: Pawel Lewandowski , Dagmara Gralak-Lachowska , Pawel Maciejewski , Bogumil Ramotowski , Andrzej Budaj , Sebastian Stec 
Published: October 2019

Abstract
Hemostatic devices used in the transradial approach (TRA) and transulnar approach (TUA) are limited. This study compared the efficacy and safety of hemostasis using the QuikClot Radial hemostatic pad (QC) vs. standard mechanical compression (SC) after coronary angiography (CAG). This prospective single-center randomized trial included CAG patients. The primary and secondary endpoints were efficacy (successful hemostasis) and safety (total artery occlusion [TAO], pseudoaneurysm, hematoma), respectively. A visual analog scale (VAS) evaluated patient pain during compression. In 2013–2017, 200 patients were randomized 2 × 2 into the: (1) TRA and TUA groups and (2) QC and SC groups. Successful hemostasis was achieved in 92 (92%) patients in the QC group and 100 (100%) patients in the SC group (p < 0.006). The TRA SC subgroup showed significantly better results than the TRA QC subgroup (100% vs. 90.0%; p < 0.03). Similar results were obtained in the TUA QC and TUA SC subgroups (95% vs. 100%; p = 0.5). The secondary endpoint was achieved in the QC and SC groups (8% vs. 9%; p = 0.8). Patients reported significantly less pain during QC application than during SC (VAS: 2.6 ± 2.6 vs. 3.4 ± 2.9; p < 0.03). In patients undergoing CAG with TRA or TUA, QC was associated with lower efficacy, less discomfort, and similar safety compared to SC.
Predominant cleavage of proteins N-terminal to serines and threonines using scandium(III) triflate
Authors: Koehler Christian J. , Thiede Bernd 
Published: October 2019

Abstract
Proteolytic digestion prior to LC–MS analysis is a key step for the identification of proteins. Digestion of proteins is typically performed with trypsin, but certain proteins or important protein sequence regions might be missed using this endoproteinase. Only few alternative endoproteinases are available and chemical cleavage of proteins is rarely used. Recently, it has been reported that some metal complexes can act as artificial proteases. In particular, the Lewis acid scandium(III) triflate has been shown to catalyze the cleavage of peptide bonds to serine and threonine residues. Therefore, we investigated if this compound can also be used for the cleavage of proteins. For this purpose, several single proteins, the 20S immune-proteasome (17 proteins), and the Universal Proteomics Standard UPS1 (48 proteins) were analyzed by MALDI–MS and/or LC–MS. A high cleavage specificity N-terminal to serine and threonine residues was observed, but also additional peptides with deviating cleavage specificity were found. Scandium(III) triflate can be a useful tool in protein analysis as no other reagent has been reported yet which showed cleavage specificity within proteins to serines and threonines.

Graphic abstract
Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer
Authors: Unterleuthner Daniela , Neuhold Patrick , Schwarz Katharina , Janker Lukas , Neuditschko Benjamin , Nivarthi Harini , Crncec Ilija , Kramer Nina , Unger Christine , Hengstschläger Markus , Eferl Robert , Moriggl Richard , Sommergruber Wolfgang , Gerner Christopher , Dolznig Helmut 
Published: October 2019

AbstractWNT2 acts as a pro-angiogenic factor in placental vascularization and increases angiogenesis in liver sinusoidal endothelial cells (ECs) and other ECs. Increased WNT2 expression is detectable in many carcinomas and participates in tumor progression. In human colorectal cancer (CRC), WNT2 is selectively elevated in cancer-associated fibroblasts (CAFs), leading to increased invasion and metastasis. However, if there is a role for WNT2 in colon cancer, angiogenesis was not addressed so far. We demonstrate that WNT2 enhances EC migration/invasion, while it induces canonical WNT signaling in a small subset of cells. Knockdown of WNT2 in CAFs significantly reduced angiogenesis in a physiologically relevant assay, which allows precise assessment of key angiogenic properties. In line with these results, expression of WNT2 in otherwise WNT2-devoid skin fibroblasts led to increased angiogenesis. In CRC xenografts, WNT2 overexpression resulted in enhanced vessel density and tumor volume. Moreover, WNT2 expression correlates with vessel markers in human CRC. Secretome profiling of CAFs by mass spectrometry and cytokine arrays revealed that proteins associated with pro-angiogenic functions are elevated by WNT2. These included extracellular matrix molecules, ANG-2, IL-6, G-CSF, and PGF. The latter three increased angiogenesis. Thus, stromal-derived WNT2 elevates angiogenesis in CRC by shifting the balance towards pro-angiogenic signals.
Understanding the influence of teacher–learner relationships on learners’ assessment perception
Authors: Schut Suzanne , van Tartwijk Jan , Driessen Erik , van der Vleuten Cees , Heeneman Sylvia 
Published: October 2019

Abstract
Low-stakes assessments are theorised to stimulate and support self-regulated learning. They are feedback-, not decision-oriented, and should hold little consequences to a learner based on their performance. The use of low-stakes assessment as a learning opportunity requires an environment in which continuous improvement is encouraged. This may be hindered by learners’ perceptions of assessment as high-stakes. Teachers play a key role in learners’ assessment perceptions. By investigating assessment perceptions through an interpersonal theory-based perspective of teacher–learner relationships, we aim to better understand the mechanisms explaining the relationship between assessment and learning within medical education. First, twenty-six purposefully selected learners, ranging from undergraduates to postgraduates in five different settings of programmatic assessment, were interviewed about their assessment task perception. Next, we conducted a focussed analysis using sensitising concepts from interpersonal theory to elucidate the influence of the teacher–learner relationship on learners’ assessment perceptions. The study showed a strong relation between learners’ perceptions of the teacher–learner relationship and their assessment task perception. Two important sources for the perception of teachers’ agency emerged from the data: positional agency and expert agency. Together with teacher’s communion level, both types of teachers’ agency are important for understanding learners’ assessment perceptions. High levels of teacher communion had a positive impact on the perception of assessment for learning, in particular in relations in which teachers’ agency was less dominantly exercised. When teachers exercised these sources of agency dominantly, learners felt inferior to their teachers, which could hinder the learning opportunity. To utilise the learning potential of low-stakes assessment, teachers are required to stimulate learner agency in safe and trusting assessment relationships, while carefully considering the influence of their own agency on learners’ assessment perceptions. Interpersonal theory offers a useful lens for understanding assessment relationships. The Interpersonal Circumplex provides opportunities for faculty development that help teachers develop positive and productive relationships with learners in which the potential of low-stakes assessments for self-regulated learning is realised.
Wilson disease missense mutations in ATP7B affect metal-binding domain structural dynamics
Authors: Shanmugavel Kumaravel Ponnandai , Kumar Ranjeet , Li Yaozong , Wittung-Stafshede Pernilla 
Published: October 2019

Abstract
Wilson disease (WD) is caused by mutations in the gene for ATP7B, a copper transport protein that regulates copper levels in cells. A large number of missense mutations have been reported to cause WD but genotype–phenotype correlations are not yet established. Since genetic screening for WD may become reality in the future, it is important to know how individual mutations affect ATP7B function, with the ultimate goal to predict pathophysiology of the disease. To begin to assess mechanisms of dysfunction, we investigated four proposed WD-causing missense mutations in metal-binding domains 5 and 6 of ATP7B. Three of the four variants showed reduced ATP7B copper transport ability in a traditional yeast assay. To probe mutation-induced structural dynamic effects at the atomic level, molecular dynamics simulations (1.5 μs simulation time for each variant) were employed. Upon comparing individual metal-binding domains with and without mutations, we identified distinct differences in structural dynamics via root-mean square fluctuation and secondary structure content analyses. Most mutations introduced distant effects resulting in increased dynamics in the copper-binding loop. Taken together, mutation-induced long-range alterations in structural dynamics provide a rationale for reduced copper transport ability.
An Improved Surface Boundary Condition for Large-Eddy Simulations Based on Monin–Obukhov Similarity Theory: Evaluation and Consequences for Grid Convergence in Neutral and Stable Conditions
Authors: Maronga Björn , Knigge Christoph , Raasch Siegfried 
Published: October 2019

Abstract
Monin–Obukhov similarity theory is used in large-eddy simulation (LES) models as a surface boundary condition to predict the surface shear stress and scalar fluxes based on the gradients between the surface and the first grid level above the surface. We outline deficiencies of this methodology, such as the systematical underestimation of the surface shear stress, and propose a modified boundary condition to correct for this issue. The proposed boundary condition is applied to a set of LES for both neutral and stable boundary layers with successively decreasing grid spacing. The results indicate that the proposed boundary condition reliably corrects the surface shear stress and the sensible heat flux, and improves grid convergence of these quantities. The LES data indicate improved grid convergence for the surface shear stress, more so than for the surface heat flux. This is either due to a limited performance of the Monin–Obukhov similarity functions or due to problems in the LES model in representing stable conditions. Furthermore, we find that the correction achieved using the proposed boundary condition does not lead to improved grid convergence of the wind-speed and temperature profiles. From this we conclude that the sensitivity of the wind-speed and temperature profiles in the LES model to the grid spacing is more likely related to under-resolved near-surface gradients and turbulent mixing at the boundary-layer top, to the SGS model formulation, and/or to numerical issues, and not to deficiencies due to the use of improper surface boundary conditions.
Twenty-five years of adaptation finance through a climate justice lens
Authors: Khan Mizan , Robinson Stacy-ann , Weikmans Romain , Ciplet David , Roberts J. Timmons 
Published: October 2019

Abstract
How much finance should be provided to support climate change adaptation and by whom? How should it be allocated, and on what basis? Over the years, various actors have expressed different normative expectations on climate finance. Which of these expectations are being met and which are not; why, and with what consequences? Have new norms and rules emerged, which remain contested? This article takes stock of the first 25+ years of adaptation finance under the United Nations Framework Convention on Climate Change (UNFCCC) and seeks to understand whether adaptation finance has become more justly governed and delivered over the past quarter century. We distinguish among three “eras” of adaptation finance: (1) the early years under the UNFCCC (1992–2008); (2) the Copenhagen shift (2009–2015); and (3) the post-Paris era (2016–2018). For each era, we systematically review the justice issues raised by evolving expectations and rules over the provision, distribution, and governance of adaptation finance. We conclude by outlining future perspectives for adaptation finance and their implications for climate justice.
The Adaptation and Feasibility of Narrative Enhancement and Cognitive Therapy (NECT) for Late-Onset Psychosis
Authors: Ching Elaine Y. N. , Smyth Lucy , De Souza Tanisha , Charlesworth Georgina 
Published: October 2019

Abstract
The aim of this study is to adapt and feasibility test the narrative component of Narrative Enhancement and Cognitive Therapy (NECT) for late-onset psychosis. This study followed the development and feasibility phases of the Medical Research Council framework. The original NECT intervention was adapted based on consultations with service users, experts, and clinicians. The evaluation of the feasibility test of the adapted intervention was guided by Orsmond and Cohn (Occup Particip Health 35(3):169–177, 2015)’s model for feasibility studies. The final adaptations consist of language, readability, and delivery. The adapted intervention was tested for feasibility and acceptability with one group of five patients recruited from a National Health Service (NHS) Trust in UK Results were mixed in participant outcomes and a likelihood of acceptability of the intervention. This indicates the need for a larger scale feasibility test to explore the identified benefits and challenges of implementing NECT in NHS or community settings for late-onset psychosis.
Evolving graphs with semantic neutral drift
Authors: Atkinson Timothy , Plump Detlef , Stepney Susan 
Published: October 2019

AbstractWe introduce the concept of Semantic Neutral Drift (SND) for genetic programming (GP), where we exploit equivalence laws to design semantics preserving mutations guaranteed to preserve individuals’ fitness scores. A number of digital circuit benchmark problems have been implemented with rule-based graph programs and empirically evaluated, demonstrating quantitative improvements in evolutionary performance. Analysis reveals that the benefits of the designed SND reside in more complex processes than simple growth of individuals, and that there are circumstances where it is beneficial to choose otherwise detrimental parameters for a GP system if that facilitates the inclusion of SND.
Evaluations as a decent knowledge base? Describing and explaining the quality of the European Commission’s ex-post legislative evaluations
Authors: van Voorst Stijn , Mastenbroek Ellen 
Published: October 2019

Abstract
Evaluations are a potentially important tool for democratic governments: they provide a basis for accountability and policy learning. To contribute to these key functions, evaluations must be of sufficient methodological quality. However, this quality is threatened by both political influences and technical complexities. This article describes and explains the variance in the quality of ex-post legislative (EPL) evaluations conducted by the European Commission, which is a frontrunner in this realm. A number of potential political and technical explanations of evaluation quality are tested with a unique, self-constructed dataset of 153 EPL evaluations. The results show that the Commission’s EPL evaluations usually apply a robust methodology, while the clarity of their scope, the accuracy of their data and the foundations of their conclusions are problematic. The variance in this quality is mainly explained by the type of evaluator: EPL evaluations conducted by external actors are of higher quality than evaluations conducted internally by the Commission.