bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Channel Length and Chevron Angle on Pressure Drop in the Entrance Region of Corrugated Rib Channels
Authors: Hamoda M. A. , Pope K. , Muzychka Y. S. 
Published: October 2019

Abstract
Plates with corrugated walls are used in plate heat exchangers for heat transfer enhancement usually at the expense of the fluid friction. In this paper, the effects of varying channel lengths and corrugation angles on the pressure drop in corrugated rib channels are examined. Water was used as the working fluid and the Reynolds number varied over the range 400 ≤ ReDe ≤ 2,500. The test fixture is constructed from aluminum and the plates core were machined with the same corrugation depth, 1.14 mm, but with different lengths, 10.16 cm and 20.32 cm and different corrugation inclination angles, 30°, 45°, and 60°. The hydraulic diameter of the formed channel is about 2.0 mm. Experimental results show that the friction factor for the short ribbed plates is significantly higher than those of the longer ribbed plates. In addition, the pressure drop increases with an increase of the corrugation angle for all ribbed plates tested. Based on the experimental results, correlations for predicting friction factor are proposed.
Performance of Concentrator Photovoltaic Systems Integrated With Double Layer Microchannel Heat Sink
Authors: Radwan Ali , Awad Mohamed M. , Ookawara Shinichi , Ahmed Mahmoud 
Published: October 2019

Abstract
In this study, a new design of double layer microchannel heat sink (DL-MCHS) has been monolithically fabricated using 3D metal printer and experimentally examined as a heat sink for concentrator photovoltaic (CPV) systems. Single phase liquid cooling using ethanol and flow boiling cooling using NOVEC-7000 coolant in the designed DL-MCHS are experimentally compared. The results proved that using the flow boiling cooling technique for the CPV systems attained a lower solar cell temperature with high temperature uniformity. In more details, flow boiling in counterflow (CF) operated DL-MCHS, attained a very low solar cell temperature close to the NOVEC-7000 boiling point with temperature uniformity of 0.2 °C over a wide range of coolant flow rate from 25–250 ml/hr.
Stability and Scalar Transport in Laminar Non-Newtonian Flow in a Bifurcating T-Junction
Authors: Chatterjee Ajay , Khalkhal Fatemeh 
Published: October 2019

Abstract
We consider the prototype bifurcating T-junction planar flow and compare the stability of the steady two-dimensional flow field for a Newtonian and a shear thinning inelastic fluid. Global stability of the flow to two-dimensional perturbations is analyzed using numerical solutions of the linear perturbation equation. Calculations are performed for two flow ratios between the main channel and the bifurcating channel, and for two different values of the time constant in the non-Newtonian rheological model. The results show that although the steady flow remains stable to two-dimensional perturbations for Newtonian Reynolds number up to ∼ 400, shear thinning is destabilizing in that the decay rate of the perturbation field is slower. The perturbation growth rate curves for all of the different cases may be correlated by volume averaging the local Reynolds number over the flow domain, indicating that the effect of shear thinning on stability may be described using a suitably defined average Reynolds number. These stability results provide some justification for CFD calculations of steady non-Newtonian two-dimensional flows presented in earlier papers. Since scalar transport is of interest in this flow field, we also present some numerical calculations for the Nusselt number profile along the bifurcating channel wall. The results show that for the shear thinning fluid the scalar transport rate is differentially larger by ∼ 75% across one of the bifurcating channel walls, a consequence of fluid rheology enhancing the effect of flow asymmetry in the entrance region of the bifurcation.
Treating schizophrenia: the quality of evidence behind treatment recommendations and how it can improve
Authors: Aran Greg , Hicks Chandler , Demand Alexander , Johnson Austin L , Beaman Jason , Bailey Yakiji , Haught Melissa , Lane Aaron , Sinnett Philip , Vassar Matt 
Published: October 2019

Objective

To assess the methodological and reporting quality of systematic reviews that comprise the American Psychiatric Association (APA)
Practice Guideline for the Treatment of Patients with Schizophrenia
and to determine the extent to which results from Cochrane systematic reviews published after guideline development would alter or confirm current recommendations.

Participants
Systematic reviews that underpinned recommendations in the APA guidelines and Cochrane systematic reviews.

Main outcome
Three independent reviewers scored all systematic reviews referenced in the guideline for quality and reporting using AMSTAR and PRISMA checklist, respectively. Items in both tools were individually graded and compared to identify consistently low-performing areas within the systematic reviews. Post hoc analysis of the Cochrane systematic reviews since the latest revision of APA’s guidelines were performed to determine whether their findings were congruent with recent recommendations.

Results
The mean score of the 57 reviews on the PRISMA checklist was 70%. The mean AMSTAR score was 6.8, correlating with a moderate quality score. Post hoc analysis revealed that 171 Cochrane reviews had been published since the APA guideline release. Only half of the reviews of pharmacological interventions confirmed current recommendations.

Conclusions and relevance
The methodological quality of the systematic reviews included in the APA guideline was deficient in key areas. Our study brings to light the importance of using high-quality evidence in the development of clinical practice guidelines. An updated APA guideline (last updated in 2009) is necessary to provide the highest quality treatment recommendations for clinicians in the management of schizophrenia.

Trial registration number
UMIN-CTR, UMIN000023099.
Maternal and perinatal outcomes by planned place of birth in Australia 2000 – 2012: a linked population data study
Authors: Homer Caroline S E , Cheah Seong L , Rossiter Chris , Dahlen Hannah G , Ellwood David , Foureur Maralyn J , Forster Della A , McLachlan Helen L , Oats Jeremy J N , Sibbritt David , Thornton Charlene , Scarf Vanessa L 
Published: October 2019

ObjectiveTo compare perinatal and maternal outcomes for Australian women with uncomplicated pregnancies according to planned place of birth, that is, in hospital labour wards, birth centres or at home.DesignA population-based retrospective design, linking and analysing routinely collected electronic data. Analysis comprised χ2tests and binary logistic regression for categorical data, yielding adjusted ORs. Continuous data were analysed using analysis of variance.SettingAll eight Australian states and territories.ParticipantsWomen with uncomplicated pregnancies who gave birth between 2000 and 2012 to a singleton baby in cephalic presentation at between 37 and 41 completed weeks’ gestation. Of the 1 251 420 births, 1 171 703 (93.6%) were planned in hospital labour wards, 71 505 (5.7%) in birth centres and 8212 (0.7%) at home.Main outcome measuresMode of birth, normal labour and birth, interventions and procedures during labour and birth, maternal complications, admission to special care/high dependency or intensive care units (mother or infant) and perinatal mortality (intrapartum stillbirth and neonatal death).ResultsCompared with planned hospital births, the odds of normal labour and birth were over twice as high in planned birth centre births (adjusted OR (AOR) 2.72; 99% CI 2.63 to 2.81) and nearly six times as high in planned home births (AOR 5.91; 99% CI 5.15 to 6.78). There were no statistically significant differences in the proportion of intrapartum stillbirths, early or late neonatal deaths between the three planned places of birth.ConclusionsThis is the first Australia-wide study to examine outcomes by planned place of birth. For healthy women in Australia having an uncomplicated pregnancy, planned births in birth centres or at home are associated with positive maternal outcomes although the number of homebirths was small overall. There were no significant differences in the perinatal mortality rate, although the absolute numbers of deaths were very small and therefore firm conclusions cannot be drawn about perinatal mortality outcomes.
Optimising medication management for polymedicated home-dwelling older adults with multiple chronic conditions: a mixed-methods study protocol
Authors: Pereira Filipa , Roux Pauline , Santiago-Delefosse Marie , von Gunten Armin , Wernli Boris , Martins Maria Manuela , Verloo Henk 
Published: October 2019

IntroductionOptimal medication management is one of the basic conditions necessary for home-dwelling older adults living with multiple chronic conditions (OAMCC) to be able to remain at home and preserve their quality of life. Currently, the reasons for such high numbers of emergency department visits and the very significant rate of hospitalisations for OAMCC, due to medication-related problems (MRPs), is poorly explored. This study aims to reveal the current state of the medication management practices of polymedicated, home-dwelling OAMCC and to make proposals for improving clinical and medication pathways through an innovative and integrated model for supporting medication management and preventing adverse health outcomes.Methods and analysisA mixed-methods study will address the medication management of polymedicated, home-dwelling OAMCC. Its explanatory sequential design will involve two major phases conducted sequentially over time. The quantitative phase will consist of retrospectively exploiting the last 4 years of electronic patient records from a local hospital (N ≈ 50 000) in order to identify the different profiles—made up of patient-related, medication-related and environment-related factors—of the polymedicated, home-dwelling OAMCC at risk of hospitalisation, emergency department visits, hospital readmission (notably for MRPs), institutionalisation or early death. The qualitative study will involve: (a) obtaining and understanding the medication management practices and experiences of the identified profiles extracted from the hospital data of OAMCC who will be interviewed at home (N ≈ 30); (b) collecting and analysing the perspectives of the formal and informal caregivers involved in medication management at home in order to cross-reference perspectives about this important dimension of care at home. Finally, the mixed-methods findings will enable the development of an innovative, integrated model of medication management based on the Agency for Clinical Innovation framework and Bodenheimer and Sinsky’s quadruple aim.Ethics and disseminationEthical approval has been obtained from the Human Research Ethics Committee of the Canton Vaud (2018-02196). Findings will be disseminated in peer-reviewed journals, professional conferences and other knowledge transfer activities with primary healthcare providers, hospital care units, informal caregivers’ and patients’ associations.
Policy addressing suicidality in children and young people: an international scoping review
Authors: Gilmour Lynne , Maxwell Margaret , Duncan Edward 
Published: October 2019

ObjectiveTo map key policy documents worldwide and establish how they address the treatment and care needs of children and young people (CYP) who are suicidal.DesignWe conducted a scoping review to systematically identify relevant key policy documents following a pre-established published protocol.Data sourcesFour databases (CINAHL; Medline; PsycINFO; The Cochrane Database of Systematic reviews) and the websites of key government, statutory and non-statutory agencies were searched. Google and Google Scholar were used to identify other policy documents and relevant grey literature. Leading experts were consulted by email.Eligibility criteria for selected studiesPolicies, policy guidance, strategies, codes of conduct, national service frameworks, national practice guidance, white and green papers, and reviews of policy—concerned with indicated suicide prevention approaches for children up to 18 years old. Limited by English language and published after 2000.Data extraction and synthesisData were extracted using a predetermined template. Second reviewers independently extracted 25%. Documents were categorised as international guidance, national policy and national guidance, and presented in a table providing a brief description of the policy, alongside how it specifically addresses suicidal CYP. Findings were further expressed using narrative synthesis.Results35 policy documents were included in the review. Although many recognise CYP as being a high-risk or priority population, most do not explicitly address suicidal CYP. In general, national guidance documents were found to convey that suicidal children should be assessed by a child and adolescent mental health practitioner but offer no clear recommendations beyond this.ConclusionThe lack of specific reference within policy documents to the treatment and care of needs of children who are suicidal highlights a potential gap in policy that could lead to the needs of suicidal children being overlooked, and varying interpretations of appropriate responses and service provision.
Developing and validating utility parameters to establish patient-reported outcome-based perioperative symptom management in patients with lung cancer: a multicentre, prospective, observational cohort study protocol
Authors: Dai Wei , Xie Shaohua , Zhang Rui , Wei Xing , Wu Chuanmei , Zhang Yuanqiang , Feng Wenhong , Liao Xiaoqing , Mu Yunfei , Zhou Heling , Cheng Xuemei , Jiang Yanhua , He Jintao , Li Qiang , Yang Xiaojun , Shi Qiuling 
Published: October 2019

IntroductionPatient-reported outcome-based symptom monitoring and alerting have been attractive for patient care after a tumour-removal surgery. However, the implementation parameters of this patient-centred symptom management system in perioperative patients with lung cancer are still lacking. We aim to develop a perioperative symptom scale (PSS) for monitoring, to determine the optimal time points for symptom assessment and to define the alert thresholds for medical intervention.Methods and analysisThis study will prospectively recruit 300 patients undergoing lung cancer surgery in six hospitals. The MD Anderson Symptom Inventory–Lung Cancer Module (MDASI-LC) is used to collect longitudinal symptom data preoperatively, daily postoperatively during in-hospital stay and weekly after discharge until 4 weeks or the start of postoperative oncological therapy. Symptoms that change significantly over time will be generated as the PSS. We will determine the optimal time points for follow-up using the generalised linear mixed-effects models. The MDASI-LC interference-measured functional status will be used as the anchor for the alert thresholds.Ethics and disseminationEthics Committee of Sichuan Cancer Hospital approved this study on 16 October 2017 (No. SCCHEC-02-2017-042). The manuscript is based on the latest protocol of Version 3.0, 15 September 2019. The results of this study will be presented at medical conferences and published in peer-reviewed journals.Trials registration numberNCT03341377.
Whole family-based physical activity promotion intervention: the Families Reporting Every Step to Health pilot randomised controlled trial protocol
Authors: Guagliano Justin M , Brown Helen Elizabeth , Coombes Emma , Haines Elizabeth S , Hughes Claire , Jones Andrew P , Morton Katie L , van Sluijs Esther 
Published: October 2019

IntroductionFamily-based physical activity (PA) interventions present a promising avenue to promote children’s activity; however, high-quality experimental research is lacking. This paper describes the protocol for the FRESH (Families Reporting Every Step to Health) pilot trial, a child-led family-based PA intervention delivered online.Methods and analysisFRESH is a three-armed, parallel-group, randomised controlled pilot trial using a 1:1:1 allocation ratio with follow-up assessments at 8 and 52 weeks postbaseline. Families will be eligible if a minimum of one child in school Years 3–6 (aged 7–11 years) and at least one adult responsible for that child are willing to participate. Family members can take part in the intervention irrespective of their participation in the accompanying evaluation and vice versa.Following baseline assessment, families will be randomly allocated to one of three arms: (1) FRESH; (2) pedometer-only or (3) no-intervention control. All family members in the pedometer-only and FRESH arms receive pedometers and generic PA promotion information. FRESH families additionally receive access to the intervention website; allowing participants to select step challenges to ‘travel’ to target cities around the world, log steps and track progress as they virtually globetrot. Control families will receive no treatment. All family members will be eligible to participate in the evaluation with two follow-ups (8 and 52 weeks). Physical (eg, fitness and blood pressure), psychosocial (eg, social support) and behavioural (eg, objectively measured family PA) measures will be collected at each time point. At 8-week follow-up, a mixed methods process evaluation will be conducted (questionnaires and family focus groups) assessing acceptability of the intervention and evaluation. FRESH families’ website engagement will also be explored.Ethics and disseminationThis study received ethical approval from the Ethics Committee for the School of the Humanities and Social Sciences at the University of Cambridge. Findings will be disseminated via peer-reviewed publications, conferences and to participating families.Trial registration numberISRCTN12789422
Prevalence and coprevalence of chronic comorbid conditions in patients with type 2 diabetes in Catalonia: a population-based cross-sectional study
Authors: Mata-Cases Manel , Franch-Nadal Josep , Real Jordi , Cedenilla Marta , Mauricio Didac 
Published: October 2019

ObjectivesTo evaluate the prevalence and coprevalence of several chronic conditions in patients with type 2 diabetes in a Mediterranean region.DesignA cross-sectional study.SettingTwo hundred and eighty-six primary care teams of the Catalonian Health Institute (Catalonia, Spain).ParticipantsWe included patients aged ≥18 years with a diagnosis of type 2 diabetes by 31 December, 2016, who were registered in the Information System for the Development of Research in primary care (SIDIAP) database. We excluded patients with a diagnosis of type 1 diabetes, gestational diabetes mellitus and any other type of diabetes.Primary and secondary outcome measuresWe collected data on diabetes-related comorbidities (ie, chronic complications, associated cardiovascular risk factors and treatment complications). Diagnoses were based on the International Classification of Diseases, 10thRevision codes recorded in the database or, for some entities, on the cut-off points for a particular test result or a specific treatment indicated for that entity. The presence and stage of chronic kidney disease (CKD) were based on the glomerular filtration rate, the CKD Epidemiology Collaboration creatinine equation and the urine albumin-to-creatinine ratio.ResultsA total of 373 185 patients were analysed. 82% of patients exhibited ≥2 comorbidities and 31% exhibited ≥4 comorbidities. The most frequent comorbidities were hypertension (72%), hyperlipidaemia (60%), obesity (45%), CKD (33%), chronic renal failure (CRF)(28%) and cardiovascular disease (23%). The most frequently coprevalent pairs of chronic conditions were the combination of hypertension with hyperlipidaemia (45%), obesity (35%), CKD (28%), CRF (25%) or cardiovascular disease (19%), as well as the combination of hyperlipidaemia with obesity (28%), CKD (21%), CRF (18%) or cardiovascular disease (15%); other common pairs of comorbidities were obesity/CKD, obesity/CRF, hypertension/retinopathy, hypertension/albuminuria, hypertension/urinary tract infection, CVD/CRF and CVD/CKD, which were each present in more than 10% of patients.ConclusionPatients with type 2 diabetes have a high frequency of coprevalence of metabolic risk factors, cardiovascular disease and CKD and thus require an integrated management approach.
Antibiotic stewardship in skin infections: a cross-sectional analysis of early-career GP’s management of impetigo
Authors: Heal Clare , Gorges Hilary , van Driel Mieke L , Tapley Amanda , Davis Josh , Davey Andrew , Holliday L , Ball Jean , Najib Nashwa , Spike Neil , FitzGerald Kristen , Magin Parker 
Published: October 2019

ObjectiveTo establish the prevalence and associations of systemic antibiotic prescription for impetigo by early-career general practitioners (GPs) (GP registrars in their first 18 months in general practice).DesignA cross-sectional analysis of data from the Registrar Clinical Encounters in Training (ReCEnT) study.SettingReCEnT is an ongoing multisite cohort study of Australian registrars’ in-consultation clinical practice across five Australian states.ParticipantsRegistrars participating in ReCEnT from 2010 to 2017.Outcome measuresManagement of impetigo with systemic antibiotics.Results1741 registrars (response rate 96%) provided data from 384 731 problems identified in 246 434 consultations. Impetigo, on first presentation or follow-up, was managed in 930 (0.38%, 95% CI 0.35 to 0.40) consultations and comprised 0.24% (95% CI 0.23 to 0.26) of problems. 683 patients presented with a new diagnosis of impetigo of which 38/683 (5.6%) were not prescribed antibiotics; 239/683 (35.0%) were prescribed solely topical antibiotics; 306/683 (44.8%) solely systemic antibiotics and 100/683 (14.6%) both systemic and topical antibiotics. The most common systemic antibiotic prescribed was cephalexin (53.5%). Variables independently associated with prescription of systemic antibiotics were an inner regional (compared with major city) location (OR 1.82, 95% CI 1.06 to 3.13; p=0.028), seeking in-consultation information or advice (OR 2.17, 95% CI 1.47 to 3.23; p<0.001) and ordering pathology (OR 2.13, 95% CI 1.37 to 3.33; p=0.01).ConclusionsAustralian early-career GPs prescribe systemic antibiotics (the majority broad-spectrum) for a high proportion of initial impetigo presentations. Impetigo guidelines should clearly specify criteria for systemic antibiotic prescription and individual antibiotic choice. The role of non-antibiotic management and topical antiseptics needs to be explored further.