bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ends justify the means! Attitude toward ambush marketing
Authors: Aytaç Muhammed Bilgehan 
Published: October 2020

PurposeThis study explores why consumers view ambush marketing as an ethical marketing approach.Design/methodology/approachA qualitative study was devised to investigate what ambush marketing means to those consumers who find it ethical or are not annoyed by it. Data were collected via focus groups.FindingsThree main themes emerged from the data analyses. The most dominant theme was Machiavellianism. Favorable evaluations of ambush marketing lean on a Machiavellistic understanding. The second was the Robin Hood effect, which is observed when the ambusher is a smaller or local brand. In the third theme, ambush attacks are considered as charismatic or enjoyable action, in what is termed dark charisma.Practical implicationsFindings of the current study suggest considerable implications both for businesses that deal with sponsorship and for organizing committees.Originality/valueThe extant literature on consumers' attitudes toward ambush marketing mostly focuses on ethical issues and/or the effectiveness of ambush marketing (i.e. harm to official sponsors), using qualitative techniques. However, the literature is devoid of studies exploring consumers' perception on ambush marketing, and more specifically, explanations of what is ethical and unethical from consumers' point of view. To best of the author's knowledge, it is the first study that seeks an explanation about consumers' positive evaluation of ambush marketing.
Investigating additive manufacturing implementation factors using integrated ISM-MICMAC approach
Authors: Sonar Harshad , Khanzode Vivek , Akarte Milind 
Published: October 2020

PurposeThe purpose of this paper is to identify various factors influencing additive manufacturing (AM) implementation from operational performance in the Indian manufacturing sector and to establish the hierarchical relationship among them.Design/methodology/approachThe methodology includes three phases, namely, identification of factors through systematic literature review (SLR), interviews with experts to capture industry perspective of AM implementation factors and to develop the hierarchical model and classify it by deriving the interrelationship between the factors using interpretive structural modeling (ISM), followed with the fuzzy Matrice d’Impacts Croisés Multiplication Appliqués à un Classement (MICMAC) analysis.FindingsThis research has identified 14 key factors that influence the successful AM implementation in the Indian manufacturing sector. Based on the analysis, top management commitment is an essential factor with high driving power, which exaggerates other factors. Factors, namely, manufacturing flexibility, operational excellence and firm competitiveness are placed at the top level of the model, which indicates that they have less driving power and organizations need to focus on those factors after implementing the bottom-level factors.Research limitations/implicationsAdditional factors may be considered, which are important for AM implementation from different industry contexts. The variations from different industry contexts and geographical locations can foster the theoretical robustness of the model.Practical implicationsThe proposed ISM model sets the directions for business managers in planning the operational strategies for addressing AM implementation issues in the Indian manufacturing sector. Also, competitive strategies may be framed by organizations based on the driving and dependence power of AM implementation factors.Originality/valueThis paper contributes by identification of AM implementation factors based on in-depth literature review as per SLR methodology and validation of these factors from a variety of industries and developing hierarchical model by integrative ISM-MICMAC approach.
Clinical practice guide for the treatment of perforating dermatosis
Authors: Kawakami Tamihiro , Akiyama Masashi , Ishida‐Yamamoto Akemi , Nakano Hajime , Mitoma Chikage , Yoneda Kozo , Suga Yasushi 
Published: October 2020

AbstractPerforating dermatoses are a heterogeneous skin disease group defined by transepidermal elimination of various skin materials. Four classical forms of primary perforating dermatosis have been described, where the transepidermal elimination mechanism represents the hallmark of the disease: acquired reactive perforating collagenosis, elastosis perforans serpiginosa, Kyrle’s disease and perforating folliculitis. Acquired reactive perforating collagenosis presents with transepidermal elimination of collagen fibers. Elastosis perforans serpiginosum presents with the elimination of elastic fibers. Kyrle’s disease presents with transepidermal elimination of abnormal keratin. In perforating folliculitis, it is the content of the follicle. We established diagnostic criteria and severity classification. In addition, the Japanese guideline for treatment of perforating dermatoses was updated using the Medical Information Network Distribution Service (MINDS) methodology. The guideline is based on a systematic published work review completed from 1989 to 2019, and on a formal consensus and approval process. Most medical published work on the treatment is limited to individual case reports and small series of patients. The guideline covers treatment options considered relevant by the expert panel and approved in Japan at the time of the consensus conference.
Centrality Asymmetry and Partner Complementarity as Influences on Alliance Dissolution
Authors: Hu Tianyou , Jain Amit , Delios Andrew 
Published: October 2020

AbstractResearch on interfirm alliances indicates that partner firms’ asymmetry in network centrality increases the likelihood of alliance dissolution because it gives rise to a power imbalance and opportunism in the partnership. We contend that this view of centrality asymmetry does not consider the binding force that network resource complementarity can provide in an alliance, which motivates partners to ally for the long term. We propose that centrality asymmetry can have both divisive and cohesive forces in an alliance, which – when considered together – lead to a prediction that centrality asymmetry has a U‐shaped relationship with alliance dissolution. Moderate levels of asymmetry lead to lower rates of dissolution than high and low levels of asymmetry. The degree of cooperation between partners and the degree of external competition reduce the effects of centrality asymmetry on alliance dissolution because they mitigate power imbalances while encouraging partners to strengthen the alliance to withstand competitive challenges.
Determinants of Taiwan's outward investment in Southeast Asia: Economic factors and institutional issues
Authors: An Thu‐Ha Thi , Yeh Kuo‐Chun 
Published: October 2020

AbstractThis paper investigates the economic and institutional determinants of Taiwan's outward direct investment in six Southeast Asian countries from 1998 to 2017, applying the panel ARDL–Pooled Mean Group estimation. We specially examine the effects of institutional quality with five dimensions inclusively, using the Worldwide Governance Indicators. The results show the locational economic factors are the primary determinants in the long run. The tight and historic trading relation with Southeast Asia has a long‐run positive effect. On the contrary, the institutional quality of the host countries has strong positive effects in both the long run and short run. Further, the paper displays the dynamics of this investment in the last 20 years. These results are important for Taiwan and Southeast Asia policy‐makers in setting up the short‐run and long‐run policies to sustain their diversified economic growth.
Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation
Authors: Fujita Harumi , Sasaki Takashi , Miyamoto Tatsuo , Akutsu Silvia Natsuko , Sato Showbu , Mori Takehiko , Nakabayashi Kazuhiko , Hata Kenichiro , Suzuki Hisato , Kosaki Kenjiro , Matsuura Shinya , Matsubara Yoichi , Amagai Masayuki , Kubo Akiharu 
Published: October 2020

AbstractDamage to the genome can accelerate aging. The percentage of aneuploid cells, that is, cells with an abnormal number of chromosomes, increases during aging; however, it is not clear whether increased aneuploidy accelerates aging. Here, we report an individual showing premature aging phenotypes of various organs including early hair loss, atrophic skin, and loss of hematopoietic stem cells; instability of chromosome numbers known as mosaic variegated aneuploidy (MVA); and spindle assembly checkpoint (SAC) failure. Exome sequencing identified a de novo heterozygous germline missense mutation of c.856C>A (p.R286S) in the mitotic activator CDC20. The mutant CDC20 showed lower binding affinity to BUBR1 during the formation of the mitotic checkpoint complex (MCC), but not during the interaction between MCC and the anaphase‐promoting complex/cyclosome (APC/C)–CDC20 complex. While heterozygous knockout of CDC20 did not induce SAC failure, knock‐in of the mutant CDC20 induced SAC failure and random aneuploidy in cultured cells, indicating that the particular missense mutation is pathogenic probably via the resultant imbalance between MCC and APC/C‐CDC20 complex. We postulate that accelerated chromosome number instability induces premature aging in humans, which may be associated with early loss of stem cells. These findings could form the basis of a novel disease model of the aging of the body and organs.
Leverage deviation from the target debt ratio and leasing
Authors: Chowdhury Hasibul , Rahman Shofiqur , Sankaran Harikumar 
Published: October 2020

AbstractWe find a negative association between the leverage deviation and leasing intensity, implying that firms actively use leasing as a source of financing when faced with a leverage deviation. This negative relation is more pronounced for firms that are underleveraged, are financially constrained, and have a high likelihood of bankruptcy, and weaker for firms with a greater need to preserve debt capacity. We attribute these incentives to distinct features of the lease contract that separate it from secured debt contracts. Overall, our results are consistent with the substitution effects of lease and debt.
Analysis of corporate social disclosures of the apparel industry following crisis: an institutional approach
Authors: Akbar Suraiyah , Deegan Craig 
Published: October 2020

AbstractThis study explores how the social and environmental information disclosed by organisations following a crisis is influenced by the institutional environment. Through content analysis, the study examines disclosures of apparel industry organisations after the Rana Plaza building collapse in Bangladesh. The study finds that the accountability demonstrated by global apparel buyers following a crisis is attributable to Western cultural expectations and norms, legitimacy concerns and global constituent pressures, while the limited accountability demonstrated by garment suppliers operating in a developing country occurs in response to apparel buyer pressures and business survival concerns.
Gut dysbiosis associated with the rats' responses in methamphetamine‐induced conditioned place preference
Authors: Yang Cheng , Fu Xiaoya , Hao Wei , Xiang Xiaojun , Liu Tieqiao , Yang Bao‐Zhu , Zhang Xiaojie 
Published: October 2020

AbstractMethamphetamine (MA) is a potent stimulant and notoriously addictive. Individuals respond to MA effects differently and thus have a varying susceptible risk of developing MA use disorder. Cumulative evidence has indicated that gut dysbiosis contributes to behavioral response to drug effects. However, the role of gut microbiota in the susceptible risk of developing MA use disorder has remained elusive. Using an MA‐induced conditioned place preference (CPP) rat model, we administrated the same dose of MA to rats, which then showed distinct preferences in drug‐related place, indicating their different responses to MA. From all of the MA‐exposed rats, the eight with the highest CPP scores were labeled as group high CPP (H‐CPP), and the eight with the lowest were labeled as group low CPP (L‐CPP). By 16S ribosomal RNA (rRNA) sequencing, we found that the gut microbiota compositions differed between H‐CPP and L‐CPP. Specifically, Akkermansia was significantly higher in H‐CPP and positively correlated with the CPP scores. Notably, H‐CPP and L‐CPP differed in the gut microbiota composition prior to the CPP training; Ruminococcus was the dominant phylotype in H‐CPP at baseline. More importantly, rats pretreated by antibiotics showed a significantly stronger MA‐induced CPP than did the controls. Our study demonstrates that the gut dysbiosis was associated with the MA‐induced CPP, indicating that the gut microbiota might be important modulators for MA‐induced behavior and vulnerability to MA use disorder.
Evaluation of resin sealer penetration of dentin following different final rinses for endodontic irrigation using confocal laser scanning microscopy
Authors: Abusteit Omar E. 
Published: October 2020

AbstractThe aim of the study was to assess the depth of sealer penetration into dentinal tubules following different final rinses and indirectly evaluate precipitation of irrigating solutions. Methods: 52 extracted maxillary incisors were prepared to size 40/04 with 6% sodium hypochlorite irrigating solution. Following power analysis, teeth were randomly divided into 4 groups (n = 13) according to final rinse. Group 1 – 17% EDTA, Saline and 2% Chlorhexidine solution; Group 2 – SmearOFF™; Group 3 – Qmix®; and Group 4 – saline control. Obturation was performed with gutta percha and resin sealer mixed with rhodamine‐B‐isothiocyanate dye using warm vertical compaction. Teeth were sectioned into apical, middle, and coronal thirds using Buehler diamond saw at 3, 6 and 9 mm from the apex. Sections were examined under confocal laser scanning microscopy, and images were exported to Image J software to measure the maximum depth of sealer penetration circumferentially. Data were analysed using a generalised linear model and post hoc multiple comparisons with significance set at P < 0.05. Group 3 had the highest depth of penetration. There were statistically significant differences between Groups 2 and 3 and control for all sections, Group 1 and control in apical section only. Conclusion: Recently developed final rinses produced higher sealer penetration and more patent dentinal tubules than using EDTA and chlorhexidine sequentially.
Perineal trauma management and follow‐up: Are we meeting the standard of care?
Authors: Peiris‐John Roshini , Park Chan Yoo (Michelle) , Wells Susan , Kool Bridget , Wise Michelle R. 
Published: October 2020

BackgroundBirth‐related third‐ and fourth‐degree perineal trauma is common and associated with short‐ and long‐term complications.AimTo conduct a review of clinical audits investigating management of women with perineal trauma.Materials and MethodsWe identified all audits undertaken in eight New Zealand public hospitals between 2005 and 2014 that investigated whether women with birth‐related third‐ and fourth‐degree perineal trauma were receiving care according to clinical guidelines. We aggregated audit results and calculated the proportion of women receiving the recommended standard of care.ResultsDuring the review period, 25 audits investigated intra‐operative (n = 11), post‐operative (n = 14) and outpatient care (n = 18). Baseline audits showed variation in care by site; intra‐operative care (range 39–96% for repair conducted under anaesthesia, 60–96% for repair by or under supervision of a senior clinician, and 33–54% for completion of Accident Compensation Corporation forms); post‐operative care (range 40–93% for prescribed antibiotics and 33–96% for stool softeners) and outpatient care (45–84% for referral to outpatient clinic and 54–78% for physiotherapy follow‐up). Sustained high quality of care and improvements in adherence with recommendations were seen for most of the follow‐up audits (eg 90% adherence for prescribed stool softeners over three audits; over 50% increase in prescribed antibiotics over seven years).ConclusionsThese clinical audits exemplify the need to measure patient care against standards, learn from the findings, implement changes to improve patient experience and reduce life‐long sequelae from perineal trauma. This review showed some progress in some care services and highlighted where further changes are needed to close evidence‐practice gaps.
Treatment patterns and outcomes among mantle cell lymphoma patients treated with ibrutinib in the United States: a retrospective electronic medical record database and chart review study
Authors: Sharman Jeff , Kabadi Shaum M. , Clark Jamyia , Andorsky David 
Published: October 2020

SummaryThe experience of patients with mantle cell lymphoma (MCL) in community oncology practices, including reasons for treatment discontinuation, is sparse. This retrospective study sought to elucidate treatment patterns and outcomes of patients with MCL treated with ibrutinib in the community setting. Patients were identified from the US Oncology Network electronic medical records database, iKnowMedTM, between 1 November 2013 and 31 October 2016. Descriptive analysis was performed to describe the demographic and clinical characteristics of the population. Kaplan–Meier estimates were performed to determine clinical outcomes. A Cox proportional hazards model was used to identify predictors of survival. Of the 1914 patients identified with MCL, 159 were treated with ibrutinib. The median age was 71 years and the majority were male (76%) and Caucasian (89%). The overall discontinuation rate was 83·6%; the most common reasons were progression (35%) and toxicities (25·6%). The median overall survival and progression‐free survival was 25·82 months (95% confidence interval [CI] 19·94, NR) and 19·55 months (95% CI 16·52, 24·28) respectively. In multivariate modelling, patient age was predictive of survival (hazard ratio 1·041, P = 0·0186). Ibrutinib was temporarily reduced in 16·4% (n = 26) and held in 30·2% (n = 48), primarily due to toxicity 66·7% (n = 32). Survival data showed similarities between community oncology practices and clinical trials.
Novel prognostic scoring system for autologous hematopoietic cell transplantation in multiple myeloma
Authors: Dhakal Binod , D’Souza Anita , Callander Natalie , Chhabra Saurabh , Fraser Raphael , Davila Omar , Anderson Kenneth , Assal Amer , Badawy Sherif M. , Berdeja Jesus , Cerny Jan , Comenzo Raymond , Chakraborty Rajshekhar , Peter Gale Robert , Kamble Rammurti , Kharfan‐Dabaja Mohamed A. , Krem Maxwell , Ganguly Siddhartha , Janakiram Murali , Kansagra Ankit , Munker Reinhold , Murthy Hemant , Patel Sagar , Kumar Shaji , Shah Nina , Qazilbash Muzaffar , Hari Parameswaran 
Published: October 2020

AbstractWe studied 2,528 patients with upfront autologous haematopoietic cell transplantation (AHCT) for multiple myeloma (MM) from 2008–2017 to develop a prognostic model to predict outcomes. High‐risk cytogenetics included t(4;14), t(14;16), t(14;20), del13q on karyotype, del17p, +1q or 1pdel. A Cox model identified factors prognostic of progression/relapse in a training subset (n = 1,246). A weighted score using these factors was assigned to a validation cohort (n = 774). Presence of high‐risk cytogenetics [hazard ratio, (HR) 1·68 (1·3–2·17)] and pre‐AHCT bone marrow plasma cells (BMPCs) ≥10% [1·68 (1·33–2·12)] were assigned 4 points each; albumin at diagnosis <3·5 g/dl [1·31 (1·07–1·61)] 2; standard risk cytogenetics 1, and no cytogenetics abnormality, BMPCs <10% at AHCT and albumin ≥3·5 g/dl at diagnosis 0 points each. A three‐category system with low risk (0–3), intermediate risk (4–8) and high risk (9–10) showed 3‐year progression‐free survival in the low vs. intermediate vs. high risk of 58% (95% CI: 52–63) vs. 49% (95% CI: 43–56) vs. 31% (95% CI: 12–51), P < 0.001 respectively, and 3‐year OS in low vs. intermediate vs. high risk of 88% (95% CI: 84–91) vs. 81% (95% CI: 76–86) vs. 64% (95% CI: 39–80); P < 0·001. Our prognostic scoring system can identify MM patients at risk for early relapse after AHCT.
Clinical application of a phenotype‐based NGS panel for differential diagnosis of inherited kidney disease and beyond
Authors: Oh Jiyoung , Shin Jae Il , Lee Keumwha , Lee CheolHo , Ko Younhee , Lee Jin‐Sung 
Published: October 2020

AbstractUnderstanding the genetic causes of kidney disease is essential for accurate diagnosis and could lead to improved therapeutic strategies and prognosis. To accurately and promptly identify the genetic background of kidney diseases, we applied a targeted next‐generation sequencing gene panel including 203 genes associated with kidney disease, as well as diseases originating in other organs with mimicking symptoms of kidney disease, to analyze 51 patients with nonspecific nephrogenic symptoms, followed by validation of its efficacy as a diagnostic tool. We simultaneously screened for copy number variants (CNVs) in each patient to obtain a higher diagnostic yield (molecular diagnostic rate: 39.2%). Notably, one patient suspected of having Bartter syndrome presented with chloride‐secreting diarrhea attributable to homozygous SLC26A3 variants. Additionally, in eight patients, NGS confirmed the genetic causes of undefined kidney diseases (8/20, 40%), and initial clinical impression and molecular diagnosis were matched in 11 patients (11/20, 55%). Moreover, we found seven novel pathogenic/likely pathogenic variants in PKD1, PKHD1, COL4A3, and SLC12A1 genes, with a possible pathogenic variant in COL4A3 (c.1229G>A) identified in two unrelated patients. These results suggest that targeted NGS‐panel testing performed with CNV analysis might be advantageous for noninvasive and comprehensive diagnosis of suspected genetic kidney diseases.
Facilitators and barriers to integrating physical health care during treatment for substance use: A socio‐ecological analysis
Authors: Osborne Briony , Kelly Peter J. , Robinson Laura D. , Ivers Rowena , Deane Frank P. , Larance Briony 
Published: October 2020

AbstractIntroduction and AimsClinical practice guidelines recommend physical health be addressed when treating substance use disorders. Yet, the integration of alcohol and other drug (AOD) treatment and physical health care is seldom actualised. This is particularly the case in the non‐government sector. Using the socio‐ecological model as a framework, this study aimed to examine the facilitators and barriers to integrating physical health in non‐government AOD services.Design and MethodsInterviews were conducted with residential and outpatient AOD services across New South Wales, Australia. Qualitative data were collected from service users (n = 20) and clinicians (n = 13). Interview data were transcribed then systematically coded and analysed using iterative categorisation.ResultsMost staff recognised physical health care as a fundamental component of treatment for substance use even when there were personal, professional and structural barriers for doing so. Service users reported a diverse range of health and social benefits when physical health care was incorporated in to AOD treatment. An exception to this was some negative experiences with health‐care providers that were not identified by staff.Discussion and ConclusionsFindings highlight the importance of developing resources to enhance the health literacy and capacity of non‐government AOD services to address the physical health of clients. Given some clients reported negative experiences with health‐care providers that were not identified by staff, services should seek regular feedback from clients regarding their experiences with external providers. The effectiveness of existing and new physical health initiatives within non‐government organisation AOD services needs more formal evaluation.