bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure analysis of three non-wood materials for liner paper
Authors: Qanytah  , Syamsu Khaswar , Fahma Farah , Pari Gustan 
Published: October 2019

AbstractThe potential use of sago pith waste, bamboo, and water hyacinth based on the characteristics of raw materials to make liner paper were studied. The analysis conducted covered the analysis of physical characteristics, chemical components, morphology (SEM), functional groups (FTIR), and crystallinity (XRD). The pulp from the three kinds of fiber was molded into paper with a certain formulation. The parameters of pulp and paper observed covered the alkaline consumption, Kappa number, pulp yield, and paper physical characteristics (grammage, bursting strength, Ring Crush Test/RCT, water content, and water absorption). The chosen paper was the paper whose characteristics resembled the quality parameter of liner paper used by the paper industry and the standard in accordance with the Indonesia’s National Standard (SNI) 14-0095-1996. The microscope images showed that the three said raw materials have long fibers: sago pith waste and water hyacinth has fibers measuring respectively 1.89±0.90 and 2.07±0.39 mm, resembling hard wood, whereas bamboos have longer fibers measuring 4.61±0.72 mm, resembling soft wood. Bamboos have the best fiber composition and characteristics for pulp and liner paper. The two paper formulas that meet the criteria for liner paper are bamboo and bamboo+water hyacinth.
Isolation of the Human Cytomegalovirus from bodily fluids
Authors: Camacho Ortega Sigrid Johanna , Bohorquez Avila Sonia Del Pilar , Velandia Romero Myriam Lucia , Castellanos Parra Jaime Eduardo 
Published: October 2019

In vitro studies on the pathogenesis of the human cytomegalovirus (HCMV) are conducted regularly using laboratory adapted strains that lose some characteristics during the adaptation process. Since HCMV is excreted from bodily fluids during infection or reactivation, this work aimed to isolate and culture HCMV from the MRC-5 human cells found in the urine, bronchoalveolar lavage, saliva, and plasma samples of pediatric patients with probable or confirmed infection. The samples were inoculated on cell cultures either for 14 days or until a cytopathic effect (CPE) of 80 % was observed. The cell lysates and supernatants were used to perform successive viral passages. Besides HCMV, the herpes simplex virus was detected from all the saliva samples. Inoculation of the HCMV positive sera induced cell clustering and immediate monolayer damage that restricted their use. One sample of bronchoalveolar lavage induced a CPE after inoculation like that of the HCMV reference strains (Towne and Merlin), which was consequently propagated and titrated. A second viral isolate derived from the urine sample of a patient with congenital infection did not demonstrate a CPE, although presence of the virus had been confirmed using PCR. The viral isolates were examined and found to be negative for adenoviruses or enteroviruses. Despite the evident difficulty encountered for the isolation and harvesting of the HCMV, this work shows that it was possible to obtain a low passage viral strain using a modified shell vial method and inoculation protocol with extended follow-up and confirmation.
Financiamento da política de assistência social: avanços e perspectivas
Authors: Passos Luana , Dos Santos Andreia Andrade , Scarpari Alan 
Published: October 2019

Esse artigo objetiva fazer um panorama do financiamento da política de assistência social, apresentando as mudanças normativas, o aporte orçamentário e as perspectivas. Como metodologia, acessou-se o levantamento da produção normativa do órgão gestor da política, que pode ser solicitado aos autores, e a análise descritiva dos dados extraídos do Painel de Orçamento Federal, do atual Ministério da Economia1, que são oriundos do Sistema Integrado de Administração Financeira do Governo Federal (SIAFI), sistema que realiza toda a execução orçamentária e financeira do governo federal. Os resultados apontam para mudanças, com base nas orientações da Política Nacional de Assistência Social (PNAS) e da Norma Operacional Básica (NOBs/SUAS), que propiciaram um novo padrão de financiamento, com adensamento da institucionalidade, maior abrangência territorial e populacional e ampliação do escopo protetivo da política. O trajeto orçamentário foi ascendente, saindo de um patamar de 0,9% do Produto Interno Bruto (PIB), em 2006, para 1,3%, em 2018. As perspectivas, porém, não são nada animadoras, tendo em vista o cenário de congelamento, em termos reais, da despesa primária da União e um fortalecimento da concepção de assistência social como caridade e benemerência. Palavras
DETECTION OF AUTOANTIBODIES RECOGNIZING CANCERRETINA ANTIGEN RECOVERIN IN BLOOD OF PATIENTS WITH NON-INVASIVE FOLLICULAR THYROID NEOPLASMS WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP)
Authors: Belousov P. V. , Bobrovskaya Ya. I. , Bogolyubova A. V. , Sazykin A. Yu. , Shebzukhov Yu. V. , Schwartz A. M. , Lanshchakov K. V. , Vanushko V. E. , Kuprash D. V. , Abrosimov A. Yu. 
Published: October 2019

Autoantibodies recognizing the cancer-retina autoantigen called recoverin (RCVRN-AutoAb) may serve as a highly specific biomarker of cancer-associated retinopathy. However, they may also be found in some cancer patients without clinical evidence of retinopathy. In the present study, dot-ELISA and Western blot assays were used to demonstrate the presence of circulating RCVRN-AutoAb in 4/7 (57%) of patients with recently recognized pathological entity, non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); other thyroid tumors represented by follicular adenomas, and classical and follicular variants of papillary thyroid carcinomas, demonstrated low frequencies of RCVRN-AutoAb (0/15, 1/20 (5%) and 1/15 (7%), respectively), with no significant differences from healthy individuals (0/15). Our data implicate the circulating RCVRN-AutoAb as a potential biomarker of NIFTP capable of discrimination of this novel pathological entity from other thyroid tumors.
Adatok a Tarnavidék, az Upponyi-hegység és környéke flórájához
Authors: Sulyok József , Beránek Ábel 
Published: October 2019

Cikkünkben a Tarna-vidék és a Bükk északi előtere közel két évtizedes florisztikai ku­ta­tá­sá­nak eredményeit foglaljuk össze, 4421 előfordulási adat közlésével (BÁ: 1665; SJ: 2752). Számos régi iro­dalmi, illetve herbáriumi adat megerősítést nyert: kiemelendő a Hypericum elegans és a Lappula he­ter­a­cantha az Upponyi-szorosból, a Cephalaria transsylvanica, Cypripedium calceolus, Diplotaxis erucoides és a Plantago indica a Tarna-vidék és a Bükk-hát területéről. Néhány korábbi (részben saját) adatot re­vi­de­ál­tunk, főleg az újabb határozókulcsok felfogásához igazodva (Carex, Chamaecytisus, Epipactis, Molinia, Sor­bus sp.). További irodalmi és herbáriumi adatok is javításra kerültek (Onosma visanii, Scutellaria co­lum­nae, Sorbus sp., Utricularia bremii/minor). A szerzők megemlítik a Ferula sadleriana felfedezését az Up­po­nyi-szorosban, ez az előfordulás valószínűleg magszórás eredménye. A szerzők cönológiai felvételeket kö­zöl­nek a Myosotis caespitosa és a Spiraea media élőhelyeiről, továbbá néhány montán- és erdőssztyep faj je­len­leg ismert lokális elterjedését is tárgyalják.
Apró közlemények
Authors: Deák Balázs , Lukács Katalin , Báthori Ferenc , Valkó Orsolya , Bauer Norbert , Molnár Csaba , Nagy László , Kulcsár László , Voigt Wilfried , Szalai-Dobosné Márta Mária 
Published: October 2019

1. Közönséges kígyónyelv (Ophioglossum vulgatum) meglepő új előfordulása a Tiszafüred–Kunhegyesi síkon
2. Útépítési nyersanyaggal behurcolt dolomitsziklagyep-fajok tömeges megjelenése Kecskeméten
3. Geranium divaricatum a Hevesi-síkon, Füzesabony mellett
4. A pókbangó (Ophrys sphegodes) új előfordulása a vasi flórajárás területén
5. A Cephalanthera longifolia var. rosea első kimutatása Magyarországon
6. Spiraea crenata a Keleti-Bakonyban
The Scientific Targets: the Myocardium, the Vasculature and the Body’s Response to Heart Failure
Authors: Vidal-Pérez Rafael , Jankowska Ewa 
Published: October 2019

Heart failure (HF) is a common but complex clinical syndrome associated with a reduced ability of a heart to pump and/or fill with blood. We now appreciate the more complex picture involving metabolic derangements, changes in foetal gene expression and abnormalities in the periphery as forming part of the HF syndrome. Therapeutic targets include the failing myocardium, the vasculature and peripheral mechanisms. The pathophysiology of HF is currently being intensively investigated, with the identification of new relevant mechanisms, some of them emerging as potential therapeutic targets.
Vasopressin Receptor Antagonists (Vaptans) in Heart Failure
Authors: Lipiec Piotr , Metra Marco 
Published: October 2019

Arginine vasopressin (a peptide neuroendocrine hormone) levels are elevated in patients with HF. Acting through 3 receptor subtypes, it can cause vasoconstriction and cardiac remodelling (receptors V1a), adrenocorticotropic hormone release (receptors V1b) and water reabsorption (receptors V2), thereby increasing preload and afterload. Vasopressin-receptor antagonists (vaptans), induce hypotonic diuresis and have been proposed as a treatment option for hyponatraemia, a known complication of HF. Three vaptans have been so tested; tolvaptan, conivaptan and lixivaptan, and two (tolvaptan and conivaptan) have been approved for clinical use in hyponatraemia (in the USA). The EVEREST trial studied tolvaptan in over 4100 patients hospitalized with an exacerbation of chronic HF with reduced LVEF. No effect was seen on long-term mortality or HF-related morbidity, but there was greater weight loss and better dyspnoea and oedema relief over the short-term. Similar results were seen in the AQUAMARINE study. The 2016 European HF guidelines, therefore gave the limited recommendation: “Tolvaptan may be used to treat patients with volume overload and resistant hyponatraemia”. Despite targeting an attractive therapeutic target, vasopressin receptor antagonists (vaptans) have to date played only a minor role in our management of HF.
Phosphodiesterase Inhibitors
Authors: Plácido Rui , Lainscak Mitja 
Published: October 2019

Phosphodiesterases (PDEs) comprise a superfamily with 11 subfamilies. Within these families, more than 40 isoforms are expressed. Phosphodiesterase-3 inhibitors (PDE3i) are used as inotrope/vasodilators for acute heart failure (HF), and PDE5i for pulmonary hypertension and erectile dysfunction. Despite being studied for chronic HF, none of the PDEis have been presently approved for such an indication itself. The PDE3is milrinone (the PROMISE trial and OPTIME-CHF), raised safety concerns. Although low-dose intravenous milrinone with a beta-blocker is till proposed by some. Enoximone failed to show significant benefits in patients with severe chronic HF in a series of phase 3 clinical trials (ESSENTIAL 1, ESSENTIAL II, EMOTE, EMPOWER). Of the PDE5is, Sildenafil is the most extensively investigated, with proven efficacy in treating erectile dysfunction and pulmonary arterial hypertension, but it has only been tested in relatively small trials in the field of HFrEF, but shows some promise in HFpEF and in pulmonary hypertension complicating HF. Elucidation of the potential clinical role of PDEis on across the spectrum of HF phenotypes will require more definitive evidence from large-scale clinical trials.
sGC Stimulators and Activators
Authors: Tolppanen Heli , Ponikowski Piotr 
Published: October 2019

Nitric oxide (NO)-soluble guanylate cyclase(sGC)-cGMP signalling is impaired in HF syndromes, which could predispose to vascular oxidative stress. Nitrates directly stimulate cGMP, but are limited by tolerance. Therapeutic targets that aim at increasing cGMP concentrations have therefore been explored. Recently, two classes of drugs have been discovered, the sGC activators and the sGC stimulators, which target two different redox states of sGC: the NO-sensitive reduced (ferrous) sGC and NO-insensitive oxidized (ferric) sGC, respectively. Cinaciguat is an activator and riociguat and vericiguat are sGC stimulators. Vericiguat is the most advanced agent in its clinical trial programme with two completed phase IIb studies, SOCRATES -REDUCED in HFrEF and SOCRATES-PRESERVED in HFpEF, with mixed results on NT-proBNP. The ongoing VICTORIA trial in HFrEF will study 4,872 participants with a mortality/morbidity end-point and VITALITY HFpEF trial will study 735 participants, with a quality of life end-point.
Adenosine Receptor Agonists
Authors: Wallner Markus , Ponikowski Piotr 
Published: October 2019

Adenosine is a purine nucleoside that binds to adenosine cell surface receptors, which are widely expressed in heart and blood vessel cells as well as in the brain, kidney and adipose tissue.There are 4 subtypes of P1 (adenosine) G protein-coupled receptors (GPCR), named A1, A2A, A2B, and A3, which mediate a variety of cardioprotective and regenerative effects. In the heart, these effects are predominantly mediated through A1 receptors (A1R), which are expressed in atrial and ventricular cardiomyocytes and smooth muscle cells. Pre-clinical studies have reported multiple potential benefits achievable by modulation of adenyl cyclase with beneficial effects in a variety of pre-clinical models of cardiovascular disease including chronic heart failure (HF). A1R blockade (e.g. rolofylline) was however not successful in the PROTECT trial, where 2033 patients with acute HF and renal dysfunction were randomized to rolofylline or placebo, showed no benefit on renal function, symptoms, rehospitalization, or mortality. Following this attention turned to partial adenosine agonists, capadenoson and neladenoson bialanate hydrochloride, which has two phase II studies underway, PANACHE (HFpEF) and PANTHEON (HFrEF).
Genes, Cells, and MiRNAs
Authors: Gara Edit , Lainscak Mitja 
Published: October 2019

Novel methods to treat HF include gene, cell and microRNA delivery. There have been few gene therapy trials in HF. The CUPID I and II trials with AAV1.SERCA2a showed unconvincing results. The STOP-HF trial using direct intra-myocardial injection of a non-integrating plasmid vector carrying stromal cell-derived factor-1 showed no clinical effects and the AC6 gene transfer trial used IC infusion of escalating doses of Ad5.hAC6 was similarly negative. Despite high hopes stem cell trials to date in HF have not shown convincing clinical benefits. More recent clinical trials in this area have investigated the injection of cell stimulating paracrine factors (peptides, small molecules, hormone-like molecules) without actual cell delivery. Micro-RNA’s (miRNAs) are small non-coding RNA strands, comprising 19-25 nucleotides, that have a distinct signalling role and a various patterns of expression in ischaemic myocardium, hypertrophy, cardiomyopathies, and overt HF. They act at the post-transcriptional regulation level. Numerous novel miRNAs have been discovered, and their in-depth role has been characterised. miRNAs can serve as therapeutic substances or therapeutic targets in a range of cardiovascular diseases. Clinical trials are likely in the near future.
Convention as the Source of the Avant-Garde. Remarks on the Inventiveness of Poetics of the Past
Authors: Niebelska-Rajca Barbara 
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 59 (2011), issue 1.
Modern theoretical-literary treatises, defined as normative poetics, are usually connected with the dominance of the convention and normativism, with obligatory rules, canonical concepts and restrictive directives hampering originality. The present text tries to revise the conviction that convention is a dominant tendency in the development of the old theoretical thought; it tends to show the avant-garde aspects of modern poetics and to present the relations between what is conventional and what is innovative in the most original theoretical texts of late Renaissance and Baroque. Examples of two avant-garde modern poetics—Francesco Patrizi’s theory of wonder formed at the end of the 16th century and the 17th century Emanuele Tesauro’s conceptistic theory—show that tradition and convention are necessary elements of inventive theories. The avant-garde of poetics of the past, contrary to the avant-garde of the 20th century, is not born from the defiance of the earlier theories but is formed by way of modernizing and transforming them. Old inventive theories—despite all the departures from tradition—are still part of the classical paradigm. Hence, the avant-garde character of late-Renaissance and Baroque theoretical reflection consists in a peculiar synergy of convention and novelty.
The First Polish-French Rendez-Vous of Cultures. Henry III of France’s (Henri de Valois’) Polish Episode
Authors: Półćwiartek-Dremierre Dorota 
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 63 (2015), issue 1.
A complex political game, differences in the level of development of the political, social and aesthetic thought, different customs, and also frequently a language gap—all these conspired against the Polish-French dialogue in the sphere of culture in the years 1573-1574. The article analyzes the opportunities for both parties to get to know each other during the Polish episode of Henri de Valois: a visit by the Polish group of envoys to Paris in the summer of 1573, and a poetical exchange between Philippe Desportes and Poles, including Jan Kochanowski, that closed the Henri period. The exchange, up till the recent times called univocally a “duel,” turns out to be, in the case of Adieu à la Pologne and Gallo crocitanti ἀμοιβή the starting of a real, albeit ephemeral dialogue beyond the political and everyday reality, one on the level of art.
Interpretation as Feeling Settled. A few Thoughts about Reading (Poems)
Authors: Antoniuk Mateusz 
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne”, vol. 59 (2011), issue 1
The article is a suggestion for an interpretation of Czesław Miłosz’s poem Biel (Whiteness) (from the volume Miasto bez imienia (City Without a Name). The accepted methodology of interpretation tries to find and define the zone of mediation between the ideal of comprehensive reading, striving after integrating and structuralizing the global meaning of the work, and the suggestions coming from post-structuralist philosophy of reading texts. The author’s own interpretation of the poem has been taken into consideration; a comparative reading of Biel has been suggested as well as of a Miłosz’s later poem Powrót do Krakowa w roku 1880 (Return to Krakow in 1880). This comparison is supposed to serve showing different strategies of creating texts and meanings used by the author of Nieobjęta ziemia (Unattainable Earth).
At the same time, at the background, a commentary to Miłosz’s poem becomes an opportunity to construct a meta-interpretative reflection. Looking at his own reading the author formulates remarks concerning the process of reading and comprehending, he introduces and analyzes the metaphor of “interpretation as feeling settled.”
The Symbolic Role of Poverty in the Franciscan Preaching of the Saxon Era
Authors: Wolański Filip 
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 61 (2013), issue 2.
The article presents selected aspects of the functioning of the concept of poverty in the narrative of Old Polish Franciscan preaching of the Saxon era. The relationship between the context formed by Old Polish culture and the role of the idea of poverty in the Franciscan movement is presented. The author attempts to present the adaptation of the topica, drawing on the broadly conceived Christian tradition, to the realities of the Polish Republic. To do so, an analysis of the discourse of various types of sermons is presented. The object of the analysis is Sunday and holiday preaching. The article, though, focuses on funeral sermons, which apparently has great significance for the Sarmatian culture. The concluding section highlights the extreme importance of the issue of poverty as one of those cultural symbols that defined the place and meaning of caritas in Old Polish culture. It was also necessary to form various aspects of the social sensitivity of those times.
Decanal Conferences of Priests in the Diocese of Kielce in Interwar Poland
Authors: Bujak Grzegorz 
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 57 (2009), issue 2.
After Poland regained independence the role of priests’ deanery conferences gained more importance. Regular deanery conventions of the clergy positively influenced pastoral work, established order in it as well as unifying its goals and methods. They also played an important role in solving the problems of local priests concerning their living standards. The bishop appreciated the significance of deanery conferences, judging them to be an important element of the system of management and control of the diocese. In 1926, a diocesan director of pastoral conferences was appointed, his aim being, among others, to set subjects for discussion at such conventions. The conferences became an important instrument for finding out about priests’ opinions and their attitudes as well as for moulding them by the diocesan authorities.
Man in the Face of Passing and the Transitory Nature of the Moment in Marcus Aurelius’ Meditations
Authors: Siwicka Małgorzata 
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 56 (2008), issue 3.
In his Meditations, the Stoic emperor Marcus Aurelius very often resorts to the motif of passing and transitory nature of human life. On the one hand, this permanent and pessimistic motif may be interpreted as a certain kind of spiritual exercise, practised not only by Stoics. On the other hand, we cannot exclude that this is a manifestation of the author’s personal views and experiences. Marcus often touched upon the topic of death, a fact that was not necessarily an expression of his fear of what was inevitable since, according to the Stoic doctrine, death belongs to the immutable order of the world and is congruous with nature, hence it is completely ac­ceptable. Marcus Aurelius is rather afraid of the transitory nature of the moment that we are given. He stresses that life “is passing away” each day and, at the same time, he is tormented with the lack of time that must be filled with good and respectable behaviour, with life in conformity with reason, or the deity. Marcus Aurelius is not frightened by death itself, but by the possibility to lose control over one’s life, loss of consciousness, and the ability to reflect (in case of an illness or old age). He also firmly stresses the importance of favours that we may and should render to others, which besides properly forming one’s soul, are the goal of human life.