bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lightweight U-Net for cloud detection of visible and thermal infrared remote sensing images
Authors: Zhang Jiaqiang , Li Xiaoyan , Li Liyuan , Sun Pengcheng , Su Xiaofeng , Hu Tingliang , Chen Fansheng 
Published: September 2020

AbstractAccurate and rapid cloud detection is exceedingly significant for improving the downlink efficiency of on-orbit data, especially for the microsatellites with limited power and computational ability. However, the inference speed and large model limit the potential of on-orbit implementation of deep-learning-based cloud detection method. In view of the above problems, this paper proposes a lightweight network based on depthwise separable convolutions to reduce the size of model and computational cost of pixel-wise cloud detection methods. The network achieves lightweight end-to-end cloud detection through extracting feature maps from the images to generate the mask with the obtained maps. For the visible and thermal infrared bands of the Landsat 8 cloud cover assessment validation dataset, the experimental results show that the pixel accuracy of the proposed method for cloud detection is higher than 90%, the inference speed is about 5 times faster than that of U-Net, and the model parameters and floating-point operations are reduced to 12.4% and 12.8% of U-Net, respectively.
Objective consequentialism and the plurality of chances
Authors: Wroński Leszek 
Published: September 2020

AbstractI claim that objective consequentialism (OC) faces a problem stemming from the existence in some situations of a plurality of chances relevant to the outcomes of an agent’s acts. I suggest that this phenomenon bears structural resemblance to the well-known Reference Class problem. I outline a few ways in which one could attempt to deal with the issue, suggesting that it is the higher-level chance that should be employed by OC.
Opioid and neuroHIV Comorbidity – Current and Future Perspectives
Authors: Fitting Sylvia , McRae MaryPeace , Hauser Kurt F. 
Published: September 2020

AbstractWith the current national opioid crisis, it is critical to examine the mechanisms underlying pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in the central nervous system (CNS). Recent advances in experimental models, methodology, and our understanding of disease processes at the molecular and cellular levels reveal opioid-HIV interactions with increasing clarity. However, despite the substantial new insight, the unique impact of opioids on the severity, progression, and prognosis of neuroHIV and HIV-associated neurocognitive disorders (HAND) are not fully understood. In this review, we explore, in detail, what is currently known about mechanisms underlying opioid interactions with HIV, with emphasis on individual HIV-1-expressed gene products at the molecular, cellular and systems levels. Furthermore, we review preclinical and clinical studies with a focus on key considerations when addressing questions of whether opioid-HIV interactive pathogenesis results in unique structural or functional deficits not seen with either disease alone. These considerations include, understanding the combined consequences of HIV-1 genetic variants, host variants, and μ-opioid receptor (MOR) and HIV chemokine co-receptor interactions on the comorbidity. Lastly, we present topics that need to be considered in the future to better understand the unique contributions of opioids to the pathophysiology of neuroHIV.
Heavy metal content and health risk assessment of a South-eastern Nigeria River
Authors: Anyanwu Emeka Donald , Nwachukwu Emeka David 
Published: September 2020

AbstractAn enormous deficiency lag exists in the demand and supply of potable water in Umuahia, Abia State, Nigeria. The people have to pay lots of money to get potable water from water vendors, and those who cannot afford to pay patronize other unwholesome sources. Ossah River, one of the local drinking water sources, was studied to assess the heavy metal content and health risk assessment vis-a-vis its suitability for human consumption. Eight (8) heavy metals (Mn, Cu, Pb, Fe, Zn, Cd, Cr and Ni) were assessed between January and June 2018 in 3 stations, using atomic absorption spectrometer, and compared with Nigerian drinking water standards. Some of the heavy metals evaluated exceeded standards and warranted health risk assessment. Health risk assessment for all the stations indicated that there is no particularly dangerous single heavy metal, but their cumulative effect, indicated by the hazard index (HI). HI for all the stations highly exceeded threshold value (1). This calls for concern for both adults and children exposed to the water through ingestion. The heavy metal contamination observed was geogenic, exacerbated by anthropogenic activities.
Erratum to: ‘Clinical impact of PSMA PET in biochemically recurrent prostate cancer; a review of the literature’
Authors: Wondergem Maurits , van der Zant Friso M. , Broos Wouter A. M. , Knol Remco J. J. 
Published: September 2020

In the article ‘Clinical impact of PSMA PET in biochemically recurrent prostate cancer; a review of the literature’ (Tijdschrift voor Urologie, October 2020), the column headings of Tab. 3 are missing. The complete table is presented …
Basal roughness of the East Antarctic Ice Sheet in relation to flow speed and basal thermal state
Authors: Eisen Olaf , Winter Anna , Steinhage Daniel , Kleiner Thomas , Humbert Angelika 
Published: September 2020

AbstractBasal motion of ice sheets depends in part on the roughness and material properties of the subglacial bed and the occurrence of water. To date, basal motion represents one of the largest uncertainties in ice-flow models. It is that component of the total flow velocity that can change most rapidly and can, therefore, facilitate rapid variations in dynamic behaviour. In this study, we investigate the subglacial properties of the East Antarctic Ice Sheet by statistically analysing the roughness of the bed topography, inferred from radio-echo sounding measurements. We analyse two sets of roughness parameters, one derived in the spatial and the other in the spectral domain, with two roughness parameters each. This enables us to compare the suitability of the four roughness parameters to classify the subglacial landscapes below the ice sheet. We further investigate the relationship of the roughness parameters with observed surface flow velocity and modelled basal temperatures of the ice sheet. We find that one of the roughness parameters, the Hurst exponent derived in the spatial domain, coincides with the thermal condition at the base of the ice sheet for slow flow velocities and varies with flow velocity.
Beneficial effect on serum cholesterol levels, but not glycaemic regulation, after replacing SFA with PUFA for 3 d: a randomised crossover trial
Authors: Gaundal Line , Myhrstad Mari C. W. , Leder Lena , Byfuglien Marte Gjeitung , Gjøvaag Terje , Rud Ida , Retterstøl Kjetil , Holven Kirsten B. , Ulven Stine M. , Telle-Hansen Vibeke H. 
Published: September 2020

AbstractReplacing intake of SFA with PUFA reduces serum cholesterol levels and CVD risk. The effect on glycaemic regulation is, however, less clear. The main objective of the present study was to investigate the short-term effect of replacing dietary SFA with PUFA on glycaemic regulation. Seventeen healthy, normal-weight participants completed a 25-d double-blind, randomised and controlled two-period crossover study. Participants were allocated to either interventions with PUFA products or SFA products (control) in a random order for three consecutive days, separated by a 1·5-week washout period between the intervention periods. Glucose, insulin and TAG were measured before and after an oral glucose tolerance test. In addition, fasting total cholesterol, NEFA and plasma total fatty acid profile were measured before and after the 3-d interventions. Fasting and postprandial glucose, insulin, and TAG levels and fasting levels of NEFA and plasma fatty acid profile did not differ between the groups. However, replacing dietary SFA with PUFA significantly reduced total cholesterol levels by 8 % after 3 d (P = 0·002). Replacing dietary SFA with PUFA for only 3 d has beneficial cardio-metabolic effects by reducing cholesterol levels in healthy individuals.
China, India, and the social construction of technology in international society: The English School meets Science and Technology Studies
Authors: Stroikos Dimitrios 
Published: September 2020

AbstractIn recent years, there has been a growing scholarly interest in how International Relations theory can contribute to our understanding of the impact of technology on global politics, underpinned mainly by an engagement with Science and Technology Studies (STS). However, less attention has been paid to the ways in which international society shapes technology. Building on sociological and historical studies of science and technology, this article outlines one way through which international society has constituted technology by developing a synthetic account of the emergence of technological advancement as a ‘standard of civilisation’ in the nineteenth century that differentiated the ‘society of civilised states’ from non-European societies, with a particular focus on China and India. In doing so, this article also highlights how this process has had a powerful and enduring influence on Chinese and Indian conceptions about science and technology. Thus, by shifting the focus from how technology shapes global politics to how international society shapes technology, this article provides new insights into the relationship between technology, power, and modernity in an interdisciplinary context. It also offers a new way of thinking about the complex dynamics of today's global politics of technology.
Changes in psychological wellbeing, attitude and information-seeking behaviour among people at the epicentre of the COVID-19 pandemic: a panel survey of residents in Hubei province, China
Authors: Chen Xi , Gao Haiyan , Zou Yuchun , Lin Fen 
Published: September 2020

AbstractWhile most research focuses on the clinical treatment of COVID-19, fewer studies have investigated individuals' responses towards this novel infectious disease. This study aims to report the temporal changes in individuals' psychological wellbeing, perceived discrimination, sociopolitical perceptions and information-seeking behaviours among the general public in Hubei, China. Data were obtained from a two-wave survey of 1902 respondents aged 18–80 in Hubei province during the peak and mitigation stages of the outbreak. The results showed that the prevalence of psychological distress dropped from over 75% to around 15% throughout the study period, but perceived discrimination remained stable. Female, middle-aged, well-educated respondents and those employed in government/public institutions/state-owned enterprises tended to report more distress. While respondents' attention on COVID-19 information kept high and stable, their sources of information diversified across different sociodemographic groups. Over time, people obtained more social support from neighbourhoods than from their friends and relatives or non-government organisations. Over 80% of respondents were satisfied with the performance of the central government, which was notably higher than their ratings on the local government and neighbourhood/village committees. The findings of this research are informative for formulating effective intervention strategies to tackle various psychosocial problems during COVID-19.
Global Spatio‐Temporal Assessment of Changes in Multiple Ecosystem Services Under Four IPCC SRES Land‐use Scenarios
Authors: Sun S. , Shi Q. 
Published: September 2020

AbstractSocial development and technological advancement have led to land use changes, influencing the structure of ecosystem services and severely impacting ecological balance. This study spatially and quantitatively assesses the effects of land‐use changes on ecosystem services based on the fourth assessment report of the Intergovernmental Panel on Climate Change (IPCC) and using the Integrated Valuation of Ecosystem Services and Tradeoff (InVEST) model. This model, applied on a global scale, was used to quantify the changes in three ecosystem services, namely, carbon storage, water yield, and sediment retention, 2010 and 2100 under four land use scenarios (A1B, A2, B1, and B2) and to evaluate the impact of land use changes to these services. The results indicate that (1) sediment retention and carbon storage under scenario B1 increase more than under other scenarios, with average global increases of 175.74 t/km2 and 913.60 Mg/km2, respectively; water yield increase only under scenario A2 between 2010 and 2100, with average global increase of 3.51 mm; (2) forest and grassland are the principal land types providing three ecosystem services globally, and decreasing the area of barren contributes to increases in three ecosystem services; and (3) when barren is converted to forest, grassland, cropland, and urban, ecosystem services all increase, strengthening the utilization of barren land can increase ecosystem services greatly. This study provides a reference for further research and the sustainable development of ecosystem services.
Ironing Out Fe Residence Time in the Dynamic Upper Ocean
Authors: Black E. E. , Kienast S. S. , Lemaitre N. , Lam P. J. , Anderson R. F. , Planquette H. , Planchon F. , Buesseler K. O. 
Published: September 2020

AbstractAlthough iron availability has been shown to limit ocean productivity and influence marine carbon cycling, the rates of processes driving iron's removal and retention in the upper ocean are poorly constrained. Using 234Th‐ and sediment‐trap data, most of which were collected through international GEOTRACES efforts, we perform an unprecedented observation‐based assessment of iron export from and residence time in the upper ocean. The majority of these new residence time estimates for total iron in the surface ocean (0–250 m) fall between 10 and 100 days. The upper ocean residence time of dissolved iron, on the other hand, varies and cycles on sub‐annual to annual timescales. Collectively, these residence times are shorter than previously thought, and the rates and timescales presented here will contribute to ongoing efforts to integrate iron into global biogeochemical models predicting climate and carbon dioxide sequestration in the ocean in the 21st century and beyond.
Heterogeneous Power‐Law Flow With Transient Creep in Southern California Following the 2010 El Mayor‐Cucapah Earthquake
Authors: Tang Chi‐Hsien , Barbot Sylvain , Hsu Ya‐Ju , Wu Yih‐Min 
Published: September 2020

AbstractThe rheology of the crust and mantle and the interaction of viscoelastic flow with seismic/aseismic slip on faults control the state of stress in the lithosphere over multiple seismic cycles. The rheological behavior of rocks is well constrained in a laboratory setting, but the in situ properties of the lithosphere and its lateral variations remain poorly known. Here, we access the lower‐crustal rheology in Southern California by exploiting 8 years of geodetic postseismic deformation following the 2010 El Mayor‐Cucapah earthquake. The data illuminate viscoelastic flow in the lower crust with lateral variations of effective viscosity correlated with the geological province. We show that a Burgers assembly with dashpots following a nonlinear constitutive law can approximate the temporal evolution of stress and strain rate, indicating the activation of nonlinear transient creep before steady‐state dislocation creep. The transient and background viscosities in the lower crust of the Salton Trough are on the order of ~1018 and ~1019 Pa s, respectively, about an order of magnitude lower than those in the surrounding regions. We highlight the importance of transient creep, nonlinear flow laws, and lateral variations of rheological properties to capture the entire history of postseismic relaxation following the El Mayor‐Cucapah earthquake.
Influence of Arctic Microlayers and Algal Cultures on Sea Spray Hygroscopicity and the Possible Implications for Mixed‐Phase Clouds
Authors: Christiansen Sigurd , Ickes Luisa , Bulatovic Ines , Leck Caroline , Murray Benjamin J. , Bertram Allan K. , Wagner Robert , Gorokhova Elena , Salter Matthew E. , Ekman Annica M. L. , Bilde Merete 
Published: September 2020

AbstractAs Arctic sea ice cover diminishes, sea spray aerosols (SSA) have a larger potential to be emitted into the Arctic atmosphere. Emitted SSA can contain organic material, but how it affects the ability of particles to act as cloud condensation nuclei (CCN) is still not well understood. Here we measure the CCN‐derived hygroscopicity of three different types of aerosol particles: (1) Sea salt aerosols made from artificial seawater, (2) aerosol generated from artificial seawater spiked with diatom species cultured in the laboratory, and (3) aerosols made from samples of sea surface microlayer (SML) collected during field campaigns in the North Atlantic and Arctic Ocean. Samples are aerosolized using a sea spray simulation tank (plunging jet) or an atomizer. We show that SSA containing diatom and microlayer exhibit similar CCN activity to inorganic sea salt with a κ value of ∼1.0. Large‐eddy simulation (LES) is then used to evaluate the general role of aerosol hygroscopicity in governing mixed‐phase low‐level cloud properties in the high Arctic. For accumulation mode aerosol, the simulated mixed‐phase cloud properties do not depend strongly on κ, unless the values are lower than 0.4. For Aitken mode aerosol, the hygroscopicity is more important; the particles can sustain the cloud if the hygroscopicity is equal to or higher than 0.4, but not otherwise. The experimental and model results combined suggest that the internal mixing of biogenic organic components in SSA does not have a substantial impact on the cloud droplet activation process and the cloud lifetime in Arctic mixed‐phase clouds.
GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies
Authors: Dai Weixing , Xu Ye , Mo Shaobo , Li Qingguo , Yu Jun , Wang Renjie , Ma Yanlei , Ni Yan , Xiang Wenqiang , Han Lingyu , Zhang Long , Cai Sanjun , Qin Jun , Chen Wen-Lian , Jia Wei , Cai Guoxiang 
Published: September 2020

AbstractCancer cells are usually characterized by hyperactive glucose metabolism, which can often lead to glucose scarcity; thus, alternative pathways to rewire cancer metabolism are required. Here, we demonstrated that GLUT3 was highly expressed in colorectal cancer (CRC) and negatively linked to CRC patient outcomes, whereas GLUT1 was not associated with CRC prognosis. Under glucose-limiting conditions, GLUT3 expedited CRC cell growth by accelerating glucose input and fuelling nucleotide synthesis. Notably, GLUT3 had a greater impact on cell growth than GLUT1 under glucose-limiting stress. Mechanistically, low-glucose stress dramatically upregulated GLUT3 via the AMPK/CREB1 pathway. Furthermore, high GLUT3 expression remarkably increased the sensitivity of CRC cells to treatment with vitamin C and vitamin C-containing regimens. Together, the results of this study highlight the importance of the AMPK/CREB1/GLUT3 pathway for CRC cells to withstand glucose-limiting stress and underscore the therapeutic potential of vitamin C in CRC with high GLUT3 expression.
Cytometric fingerprints of gut microbiota predict Crohn’s disease state
Authors: Rubbens Peter , Props Ruben , Kerckhof Frederiek-Maarten , Boon Nico , Waegeman Willem 
Published: September 2020

Abstract
Variations in the gut microbiome have been associated with changes in health state such as Crohn’s disease (CD). Most surveys characterize the microbiome through analysis of the 16S rRNA gene. An alternative technology that can be used is flow cytometry. In this report, we reanalyzed a disease cohort that has been characterized by both technologies. Changes in microbial community structure are reflected in both types of data. We demonstrate that cytometric fingerprints can be used as a diagnostic tool in order to classify samples according to CD state. These results highlight the potential of flow cytometry to perform rapid diagnostics of microbiome-associated diseases.
MDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response
Authors: Pulido Miguel Rodríguez , Martínez-Salas Encarnación , Sobrino Francisco , Sáiz Margarita 
Published: September 2020

AbstractThe RIG-I-like receptor (RLR) melanoma differentiation-associated gene 5 (MDA5) plays a key role in triggering innate antiviral response during infection by RNA viruses. MDA5 activation leads to transcription induction of type-I interferon (IFN) and proinflammatory cytokines. MDA5 has also been associated with autoimmune and autoinflammatory diseases by dysfunctional activation of innate immune response in the absence of infection. Here, we show how foot-and-mouth disease virus (FMDV) counteracts the specific antiviral effect exerted by MDA5 targeting the protein for cleavage by the viral Leader protease (Lpro). MDA5 overexpression had an inhibitory effect on FMDV infection in IFN-competent cells. Remarkably, immunostimulatory viral RNA co-immunoprecipitated with MDA5 in infected cells. Moreover, specific cleavage of MDA5 by Lpro was detected in co-transfected cells, as well as during the course of FMDV infection. A significant reduction in IFN induction associated with MDA5 cleavage was detected by comparison with a non-cleavable MDA5 mutant protein with preserved antiviral activity. The Lpro cleavage site in MDA5 was identified as the RGRAR sequence in the conserved helicase motif VI, coinciding with that recently reported for Lpro in LGP2, another member of the RLRs family involved in antiviral defenses. Interestingly, specific mutations within the MDA5 Lpro target sequence have been associated with immune disease in mice and humans. Our results reveal a pleiotropic strategy for immune evasion based on a viral protease targeting phylogenetically conserved domains of immune sensors. Identification of viral strategies aimed to disrupt MDA5 functionality may also contribute to develop new treatment tools for MDA5-related disorders.
Stochastic resonance in MoS2 photodetector
Authors: Dodda Akhil , Oberoi Aaryan , Sebastian Amritanand , Choudhury Tanushree H. , Redwing Joan M. , Das Saptarshi 
Published: September 2020

AbstractIn this article, we adopt a radical approach for next generation ultra-low-power sensor design by embracing the evolutionary success of animals with extraordinary sensory information processing capabilities that allow them to survive in extreme and resource constrained environments. Stochastic resonance (SR) is one of those astounding phenomena, where noise, which is considered detrimental for electronic circuits and communication systems, plays a constructive role in the detection of weak signals. Here, we show SR in a photodetector based on monolayer MoS2 for detecting ultra-low-intensity subthreshold optical signals from a distant light emitting diode (LED). We demonstrate that weak periodic LED signals, which are otherwise undetectable, can be detected by a MoS2 photodetector in the presence of a finite and optimum amount of white Gaussian noise at a frugal energy expenditure of few tens of nano-Joules. The concept of SR is generic in nature and can be extended beyond photodetector to any other sensors.