bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dependence of episodic accretion on eccentricity during the formation of binary stars
Authors: Kuruwita Rajika L. , Federrath Christoph , Haugbølle Troels 
Published: June 2020

Context. Episodic accretion has been observed in short-period binaries, where bursts of accretion occur at periastron. The binary trigger hypothesis has also been suggested as a driver for accretion during protostellar stages.
Aims. Our goal is to investigate how the strength of episodic accretion bursts depends on eccentricity.
Methods. We investigate the binary trigger hypothesis in longer-period (> 20 yr) binaries by carrying out three-dimensional magnetohydrodynamical simulations of the formation of low-mass binary stars down to final separations of ∼10 AU, including the effects of gas turbulence and magnetic fields. We ran two simulations with an initial turbulent gas core of one solar mass each and two different initial turbulent Mach numbers, ℳ = σv/cs = 0.1 and ℳ = 0.2, for 6500 yr after protostar formation.
Results. We observe bursts of accretion at periastron during the early stages when the eccentricity of the binary system is still high. We find that this correlation between bursts of accretion and passing periastron breaks down at later stages because of the gradual circularisation of the orbits. For eccentricities greater than e = 0.2, we observe episodic accretion triggered near periastron. However, we do not find any strong correlation between the strength of episodic accretion and eccentricity. The strength of accretion is defined as the ratio of the burst accretion rate to the quiescent accretion rate. We determine that accretion events are likely triggered by torques between the rotation of the circumstellar disc and the approaching binary stars. We compare our results with observational data of episodic accretion in short-period binaries and find good agreement between our simulations and the observations.
Conclusions. We conclude that episodic accretion is a universal mechanism operating in eccentric young binary-star systems, independent of separation, and it should be observable in long-period binaries as well as in short-period binaries. Nevertheless, the strength depends on the torques and hence the separation at periastron.
Uncertainty and sensitivity analysis applied to a rammed earth wall: evaluation of the discrepancies between experimental and numerical data
Authors: Bui Rudy , Goffart Jeanne , McGregor Fionn , Woloszyn Monika , Fabbri Antonin , Grillet Anne-Cécile 
Published: June 2020

Due to the environmental impact of building materials, researches on sustainable materials, such as bio-based and earth materials, are now widespread. These materials offer numerous qualities such as their availability, recyclability and their ability to dampen the indoor relative humidity variations due to their hygroscopicity. As these materials can absorb large amount of humidity, numerical and experimental studies of their hygrothermal behaviour are crucial to assess their durability.
To validate a hygrothermal model, numerical and experimental data have to be confronted. Such confrontation must take into consideration the uncertainties related to the experimental protocol, but also to the model. Statistical tools such as uncertainty and global sensitivity analysis are essential for this task. The uncertainty analysis estimates the robustness of the model, while the global sensitivity analysis identifies the most influential input(s) responsible for this robustness. However, these methods are not commonly used because of the complexity of hygrothermal models, and therefore the prohibitive simulation cost.
This study presents a methodology for comparing the numerical and experimental data of a rammed earth wall subjected to varying temperature and relative humidity conditions. The main objectives are the investigation of the uncertainties impact, the estimation of the model robustness, and finally the identification of the input(s) responsible for the discrepancies between numerical and experimental data. To do so, a recent and low-cost global variance-based sensitivity method, named RBD-FAST, is applied. First, the uncertainty propagation through the model is calculated, then the sensitivity indices are estimated. They represent the part of the output variability related to each input variability. The output of interest is the vapour pressure in the middle of the wall to confront it to the experimental measurement. Good agreement is obtained between the experimental and numerical results. It is also highlighted that the sorption isotherm is the main factor influencing the vapour pressure in the material.
Finite element error analysis of surface Stokes equations in stream function formulation
Authors: Brandner Philip , Reusken Arnold 
Published: June 2020

We consider a surface Stokes problem in stream function formulation on a simply connected oriented surface Γ ⊂ ℝ3 without boundary. This formulation leads to a coupled system of two second order scalar surface partial differential equations (for the stream function and an auxiliary variable). To this coupled system a trace finite element discretization method is applied. The main topic of the paper is an error analysis of this discretization method, resulting in optimal order discretization error bounds. The analysis applies to the surface finite element method of Dziuk–Elliott, too. We also investigate methods for reconstructing velocity and pressure from the stream function approximation. Results of numerical experiments are included.
Aktuelle Standards in der Diagnostik und Therapie von peripheren T-Zell-Lymphomen
Authors: Staber Philipp , Hopfinger Georg 
Published: June 2020

WAS IST NEU?
Neue WHO-Klassifikation 2017 für Lymphome und molekulare Marker Es erfolgte gegenüber der Version von 2008 eine genauere Definition einzelner Entitäten, wie z. B. dem anaplastischen großzelligen Lymphom (ALK). Darüber hinaus wird der Terminus des Enteropathie-assoziierten T-Zell-Lymphoms (EATCL, Typ 1) nunmehr für die mit einer Zöliakie assoziierten Form verwendet. Der Einsatz molekularer Marker mittels Next-Generation-Sequencing (NGS) ermöglicht einerseits eine bessere Differenzialdiagnostik; so ist z. B. das angioimmunoblastische Lymphom (AITL) durch das Vorliegen von TET2-, RHOA-, IDH2- und DNMT3A-Mutationen charakterisiert. Andererseits haben bestimmte Mutationen auch prognostische Bedeutung. Beim ALCL/ALK– ist der Nachweis eines DUSP22/IRF4-Rearrangements mit einer besseren, der Nachweis von TP63 mit einer schlechteren Prognose assoziiert.
Klinisches Bild und Prognose Neben sog. B-Symptomatik und nodaler Manifestation können auch extranodale Manifestationen wie Hautinfiltrate in bis zu 20 % beobachtet werden. Als Zeichen eines dysregulierten Immunsystems können beim AITL eine polyklonale Hypergammaglobulinämie, Coombspositive hämolytische Anämie und Immundefizienz auftreten.
Fortschritte in der Therapie Durch Kombination des Immunkonjugats Brentuximab-Vedotin (BV) mit Chemotherapie konnte erstmals ein positiver Effekt auf krankheitsfreies (PFS) und Gesamtüberleben (OS) bei CD30+-PTCL gezeigt werden.
Ausblick Gegenwärtig werden neue Therapieansätze, z. B. mit der demethylierenden Substanz 5-Azacytidin bei AITL und PTCL mit einem T-Follikel-Helper-Type (TFH), geprüft.
Cesarean Section Rate Analysis in a Tertiary Hospital in Portugal According to Robson Ten Group Classification System
Authors: Vargas Sara , Rego Susana , Clode Nuno 
Published: June 2020

Abstract
Objective The Robson 10 group classification system (RTGCS) is a reproducible, clinically relevant and prospective classification system proposed by the World Health Organization (WHO) as a global standard for assessing, monitoring and comparing cesarean section (CS) rates. The purpose of the present study is to analyze CS rates according to the RTGCS over a 3-year period and to identify the main contributors to this rate.
Methods We reviewed data regarding deliveries performed from 2014 up to 2016 in a tertiary hospital in Portugal, and classified all women according to the RTGCS. We analyzed the CS rate in each group.
Results We included data from 6,369 deliveries. Groups 1 (n = 1,703), 2 (n = 1,229) and 3 (n = 1,382) represented 67.7% of the obstetric population. The global CS rate was 25% (n = 1,594). Groups 1, 2, 5 and 10 were responsible for 74.2% of global CS deliveries.
Conclusion As expected, Groups 1, 2, 5 and 10 were the greatest contributors to the overall CS rate. An attempt to increase the number of vaginal deliveries in these groups, especially in Groups 2 and 5, might contribute to the reduction of the CS rate.
The Role of Health-related Behaviors in Gestational Weight Gain among Women with Overweight and Obesity: A Cross-sectional Analysis
Authors: Paulino Daiane Sofia Morais , Pinho-Pompeu Maira , Raikov Fernanda , Freitas-Jesus Juliana Vasconcellos , Machado Helymar Costa , Surita Fernanda Garanhani 
Published: June 2020

AbstractObjective To evaluate the influence of health-related behaviors including food intake, physical activity, sleep time, smoking habits, stress, depression, and optimism on excessive gestational weight gain (GWG) among women with overweight and obesity.Methods A cross-sectional study was conducted at the Women's Hospital of the Universidade de Campinas, Campinas, state of São Paulo, Brazil, with 386 mediate postpartum women that fit the inclusion criteria of ≥ 19 years old, first prenatal care visit at or before 14 weeks, and single live baby. Dietary habits, physical exercise practice, sleep duration, smoking and alcohol habits were self-reported. Psychosocial history was evaluated using the Edinburgh Postpartum Depression Scale (EPDS), Perceived Stress Scale (PSS), and Life Orientation Test-Revised (LOT-R). Sociodemographic, obstetric, anthropometric, and neonatal data were retrieved from medical records. Descriptive statistics and stepwise logistic regression were performed.Results The prevalence of overweight and obesity was 29.27% and 24.61%, respectively, according to the body mass index (BMI). Excessive GWG was observed in 47.79% of women with overweight and in 45.26% of women with obesity. Excessive GWG among overweight and obese women was associated with inadequate vegetable and bean consumption (odds ratio [OR] = 2.95, 95% confidence interval [CI]: 1.35–6.46 and OR = 1.91; 95%CI: 1.01–3.63, respectively) and stress (OR = 1.63; 95%CI 1.01–2.64). After adjustment by maternal age, multiparity, sleep duration, smoking, and alcohol intake, we found that stress (PSS ≥ 20) was associated with excessive GWG in women with overweight or obesity (OR: 1.75; 95%CI: 1.03–2.96).Conclusion Among women with overweight and obesity, stress is the main variable associated with excessive GWG. Inadequate vegetables and beans consumption also showed association with excessive GWG.
Cellular Angiofibroma: A Rare Vulvar Tumor Case Report
Authors: Fachada Ana Helena Barbosa , Pais Cátia Sofia Guilherme Ferreira , Fernandes Marta Andrea Ferreira , Dias Nuno Jorge Lopes , Pipa António Manuel Leitão Loureiro 
Published: June 2020

AbstractCellular angiofibroma (CA)is a rare benign mesenchymal tumor. In women, it occurs mainly in the vulvovaginal region, with vulvar location in 70% of the cases. Its clinical presentation is nonspecific and similar to several other vulvar tumors of different cellular origins. Thus, its histological and immunohistochemical features allow distinction from other tumors. Cellular angiofibromas have good prognosis, despite some risk of relapse. The authors present the case of a 49-year-old woman with a bulky right vulvar lesion, for which the preoperative diagnosis was a Bartholin cyst, but the histological and immunohistochemical evaluation yielded a CA.
High-risk Human Papillomavirus Testing for Triage of Women with Previous Cytological Abnormalities from the Vale do Ribeira Region
Authors: Lorente Sandra , Fernandes Natália Coelho Couto de Azevedo , Etlinger-Colonelli Daniela , Réssio Rodrigo Albergaria , Oliveira Sonia Maria Pereira de , Catarino Regina Maria 
Published: June 2020

Abstract
Objective To evaluate the performance of the hybrid capture 2 (HC2) high-risk papillomavirus (hrHPV) assay and cytological test in women with previous abnormalities, to detect cervical intraepithelial neoplasia grade 2 or worse (≥ CIN 2).
Methods A cytological test and HC2 (Qiagen, Gaithersburg, Maryland, EUA) for hrHPV were conducted in 359 liquid-based (Sure Path, Becton Dickinson, TriPath Imaging, Burlington, NC, USA) samples collected from women from the Vale do Ribeira Region, during July 2013 and September 2015 with previous cytology classified as atypical squamous cells of undetermined significance (ASC-US), low-grade squamous intraepithelial lesion (LSIL), atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (ASC-H), and atypical glandular cells (AGC). The histopathological examination was conducted in 179 women. The performance evaluations were calculated using the “exact” Clopper-Pearson 95% confidence interval (CI) test by MEDCALC (Medcalc Software Ltd, Ostend, Belgium).
Results The ≥ CIN 2 frequency was 11.7% (21/179). The HC2 for hrHPV and repeat cytology to detect ≥ CIN 2 obtained, respectively, a sensitivity of 90.5% (95%CI = 69.6–98.8) and 90.5%, (95%CI = 69.6–98.8), a specificity of 65.8% (95% CI = 57.9–73.2) and 43.7% (95%CI = 35.8–51.8), a positive predictive value of 26.0% (95% CI = 21.4–31.3) and 17.6%, (95%CI = 14.9–20.6), and a negative predictive value of 98.1% (95%CI = 93.3–99.5) and 97.2% (95% CI = 90.1–99.2).
Conclusion Hybrid capture 2 for hrHPV improves the performance of the detection of ≥ CIN 2, without compromising sensitivity, and provides a greater safety margin to return to the triennial screening of women undergoing follow-up due to previous abnormalities, without underlying ≥ CIN 2.
Rhodium-Catalyzed Ortho-Vinylation of 2-Arylpyridines and Its Application in the Total Synthesis of Palmatine
Authors: Lv Shan , Nie Ruifang , Guo Lingmei , Zheng Yang , Liu Yanzhao , Guo Li , Wu Yong 
Published: June 2020

AbstractAn efficient protocol by Rh-catalyzed direct C–H vinylation of 2-arylpyridines with a commercially available and air-stable potassium vinyl donor has been developed. This method affords the corresponding pyridinyl styrene derivative with moderate to excellent yields under mild conditions, which is extremely beneficial to the total synthesis of the natural product palmatine.
Antenatal Corticosteroids for Pregnant Women at High Risk of Preterm Delivery with COVID-19 Infection: A Decision Analysis
Authors: Packer Claire H. , Zhou Clarice G. , Hersh Alyssa R. , Allen Allison J. , Hermesch Amy C. , Caughey Aaron B. 
Published: June 2020

Objective Antenatal corticosteroids given prior to preterm deliveries reduce the risk of adverse neonatal outcomes. However, steroid administration in the setting of a viral respiratory infection can worsen maternal outcomes. Therefore, the decision to administer corticosteroids must balance the neonatal benefits with the potential harm to the mother if she is infected with the novel coronavirus disease 2019 (COVID-19). This study aimed to determine the gestational ages for which administering antenatal corticosteroids to women at high risk of preterm labor with concurrent COVID-19 infection results in improved combined maternal and infant outcomes.
Study Design A decision-analytic model using TreeAge (2020) software was constructed for a theoretical cohort of hospitalized women with COVID-19 in the United States. All model inputs were derived from the literature. Outcomes included maternal intensive care unit (ICU) admission and death, along with infant outcomes of death, respiratory distress syndrome, intraventricular hemorrhage, and neurodevelopmental delay. Quality-adjusted life years (QALYs) were assessed from the maternal and infant perspectives. Sensitivity analyses were performed to determine if the results were robust over a range of assumptions.
Results In our theoretical cohort of 10,000 women delivering between 24 and 33 weeks of gestation with COVID-19, corticosteroid administration resulted in 2,200 women admitted to the ICU and 110 maternal deaths. No antenatal corticosteroid use resulted in 1,500 ICU admissions and 75 maternal deaths. Overall, we found that corticosteroid administration resulted in higher combined QALYs up to 31 weeks of gestation in all hospitalized patients, and up to 29 weeks of gestation in ICU patients.
Conclusion Administration of antenatal corticosteroids at less than 32 weeks of gestation for hospitalized patients and less than 30 weeks of gestation for patients admitted to the ICU resulted in higher combined maternal and infant outcomes compared with expectant management for women at high risk of preterm birth with COVID-19 infection. These results can guide clinicians in their counseling and management of these pregnant women.
Key Points
Association of Successful Ultrasound-Accelerated Catheter-Directed Thrombolysis with Postthrombotic Syndrome: A Post Hoc Analysis of the CAVA Trial
Authors: Notten Pascale , Arnoldussen Carsten W. K. P. , Brans Rutger , de Smet André A. E. A. , Tick Lidwine W. , van de Poel Marlène H. W. , Wikkeling Otmar R. M. , Vleming Louis-Jean , Koster Ad , Jie Kon-Siong G. , Jacobs Esther M. G. , Ebben Harm P. , Planken Nils , ten Cate Hugo , Wittens Cees H. A. , ten Cate-Hoek Arina J. 
Published: June 2020

Abstract
Background The CAVA trial did not show the anticipated risk reduction for postthrombotic syndrome (PTS) after thrombus removal via additional ultrasound-accelerated catheter-directed thrombolysis (UACDT) in patients with acute iliofemoral deep vein thrombosis (IFDVT). Difficulties in achieving an effective degree of recanalization through thrombolysis may have influenced outcomes. We therefore assessed whether successful UACDT (restored patency ≥ 90%) did reduce the development of PTS.
Methods This CAVA trial post hoc analysis compared the proportion of PTS at 1-year follow-up between patients with successful UACDT and patients that received standard treatment only. In addition, clinical impact as well as determinants of successful thrombolysis were explored.
Results UACDT was initiated in 77 (50.7%) patients and considered successful in 41 (53.2%, interrater agreement κ = 0.7, 95% confidence interval 0.47–0.83). PTS developed in 15/41 (36.6%) patients in the successful UACDT group versus 33/75 (44.0%) controls (p = 0.44). In this comparison, successful UACDT was associated with lower Venous Clinical Severity Score (3.50 ± 2.57 vs. 4.82 ± 2.74, p = 0.02) and higher EuroQOL-5D (EQ-5D) scores (40.2 ± 36.4 vs. 23.4 ± 34.4, p = 0.01). Compared with unsuccessful UACDT, successful UACDT was associated with a shorter symptom duration at inclusion (p = 0.05), and higher rates of performed adjunctive procedures (p < 0.001) and stent placement (p < 0.001).
Conclusion Successful UACDT was not associated with a reduced proportion of PTS 1 year after acute IFDVT compared with patients receiving standard treatment alone. There was, however, a significant reduction in symptom severity and improvement of generic quality of life according to the EQ-5D. Better patient selection and optimization of treatment protocols are needed to assess the full potential of UACDT for the prevention of PTS.
Trial Registration Number ClinicalTrials.gov number, NCT00970619.
Intraoperative Lumbar Drain Placement in Endoscopic Neurosurgical Procedures: Technical Challenges and Complications—A Prospective Observational Study
Authors: Koshy Mridul S. , Singh Georgene , Yadav Bijesh , Mariappan Ramamani , Pappachan Liby G. ,   Krishnaprabhu
Published: June 2020

Abstract
Background Perioperative placement of lumbar drain (LD) is being increasingly preferred in the endoscopic base of skull procedures to provide optimal surgical conditions. This study aims to determine the incidence of technical difficulties and complications associated with LD placement.
Materials and Methods A total of 50 patients undergoing transnasal transsphenoidal surgery were included in the study after obtaining written informed consent. Intraoperatively, LD was placed using an 18-gauge epidural catheter. Technical difficulties in LD placement were assessed by the number of attempts, levels attempted, difficulty in siting catheter, and obtaining free flow of cerebrospinal fluid (CSF). The incidence of complications such as postdural puncture headache (PDPH), meningitis headache, and backache was studied.
Results Successful LD placement in the first attempt was obtained in 36% of the patients. Technical difficulties were encountered in 64% of the patients. Despite successful LD placement in 90% of the patients, 32% required manipulations to increase CSF flow. The drain failure rate was 10%. Drainage of >20 to 30 mL of CSF/hour was significantly associated with better surgical conditions (p < 0.05). The incidence of headache was 56% and that of backache was 26%. Headache was significantly related to difficulty in tapping CSF (p = 0.032), and backache was significantly related to the number of attempts (p < 0.001), levels attempted (p = 0.001), and large CSF volume (p = 0.004). There were no incidences of PDPH or meningitis in our series.
Conclusion We conclude that the incidence of technical difficulties in LD placement with epidural catheters is high. Use of standard well-functioning LD catheters will assist in improving surgical conditions.
Gastrointestinal and Liver Manifestations of COVID-19
Authors: Taneja Sunil , Mehtani Rohit , Chawla Yogesh Kumar 
Published: June 2020

AbstractA novel Coronavirus, SARS-CoV-2 illness, has spread throughout the world after the first case was reported from Wuhan, China, in December 2019. This illness typically causes respiratory symptoms like fever, cough, and shortness of breath, although atypical presentation with gastrointestinal symptoms like abdominal pain, nausea, vomiting, or diarrhea are being increasingly reported. The viral RNA has been detected in saliva and stool of such patients, which raises concerns regarding the risk of transmission during gastrointestinal (GI) endoscopy. Many patients also have liver involvement, with the most common manifestation being deranged liver function tests. This review highlights the symptomatology, mechanism, and histopathology findings of SARS-CoV-2 in GI tract and liver. This review also focuses on implications of COVID-19 in patients afflicted with chronic liver disease and in patients undergoing liver transplantation.
Ocean mixing and heat transport processes observed under the Ross Ice Shelf control its basal melting
Authors: Stevens Craig , Hulbe Christina , Brewer Mike , Stewart Craig , Robinson Natalie , Ohneiser Christian , Jendersie Stefan 
Published: June 2020

SignificanceThis study describes measurements of the ocean beneath the center of the Ross Ice Shelf, the Earth’s largest ice shelf. Ice shelves experience melting from below by the ocean and so are vulnerable to a warming climate system. We present the second dataset ever collected from this region, the first having been gathered 40 y prior. Our data provide a basis for better understanding the complex processes that drive melting. They illustrate the degree of variability in the mid-water column, a region largely ignored in modeling. We also observed ephemeral refreezing on the ice shelf underside, with implications for both melt rate and upper ocean dynamics. This insight emphasizes the importance of in situ observations in undersampled environments.