bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linc-OIP5 in the breast cancer cells regulates angiogenesis of human umbilical vein endothelial cells through YAP1/Notch/NRP1 signaling circuit at a tumor microenvironment
Authors: Zhu Qing , Li Jingchao , Wu Qi , Cheng Yongxia , Zheng Huizhe , Zhan Tao , Wang Hongwei , Yang Yue , Wang Hongyan , Liu Ye , Guo Sufen 
Published: February 2020

Abstract
Background
LincRNAs have been revealed to be tightly associated with various tumorigeneses and cancer development, but the roles of specific lincRNA on tumor-related angiogenesis was hardly studied. Here, we aimed to investigate whether linc-OIP5 in breast cancer cells affects the angiogenesis of HUVECs and whether the linc-OIP5 regulations are involved in angiogenesis-related Notch and Hippo signaling pathways.

Methods
A trans-well system co-cultured HUVECs with linc-OIP5 knockdown breast cancer cell MDA-MB-231 was utilized to study the proliferation, migration and tube formation abilities of HUVECs and alterations of related signaling indicators in breast cancer cells and their conditioned medium through a series of cell and molecular experiments.

Results
Overexpressed linc-OIP5, YAP1, and JAG1 were found in breast cancer cell lines MCF7 and MDA-MB-231 and the expression levels of YAP1 and JAG1 were proportional to the breast cancer tissue grades. MDA-MB-231 cells with linc-OIP5 knockdown led to weakened proliferation, migration, and tube formation capacity of co-cultured HUVECs. Besides, linc-OIP5 knockdown in co-cultured MDA-MB-231 cells showed downregulated YAP1 and JAG1 expression, combined with a reduced JAG1 level in conditioned medium. Furthermore, a disrupted DLL4/Notch/NRP1 signaling in co-cultured HUVECs were also discovered under this condition.

Conclusion
Hence, linc-OIP5 in MDA-MB-231 breast cancer cells may act on the upstream of the YAP1/Notch/NRP1 signaling circuit to affect proliferation, migration, and tube formation of co-cultured HUVECs in a non-cellular direct contact way through JAG1 in conditioned medium. These findings at least partially provide a new angiogenic signaling circuit in breast cancers and suggest linc-OIP5 could be considered as a therapeutic target in angiogenesis of breast cancers.
Aiming for better use of convenience food: an analysis based on meal production functions at home
Authors: Nakano Satoshi , Washizu Ayu 
Published: February 2020

Abstract
Background
In recent years, the evaluation of convenience food has changed. It came to be considered not to have a negative effect on health and is now positioned as a tool to support dietary habits of elderly and other people. In advanced countries where the population is aging, convenience foods are expected to improve the eating habits of the elderly.

Methods
We defined the indicators of cooking effort and usage intensity of convenience food and presented a model wherein a “meal” is home-produced. In the model, a home cook decides the optimal cooking effort to apply for a given usage intensity of convenience food. Using an empirical form of the proposed model, we performed a multiple regression analysis and calculated “the elasticity of cooking effort with respect to the usage intensity of convenience food” for home cooks, with each attribute defined by a combination of different personality and demographic factors, using the estimated coefficients.

Results
Regression analysis results revealed a negative correlation between cooking effort and the usage intensity of convenience food, which is consistent with our theoretical model of home meal production. The results showed that home cooks who have special food preferences may not be satisfied with accepting convenience foods purchased from the market as they are and that these home cooks will require a higher cooking effort to obtain higher satisfaction. The elasticity of elderly home cooks was low, implying that they are not flexible enough to accept convenience food.

Conclusions
The results revealed that existing convenience foods do not have the same impact on home cooks with attributes. This problem can be solved with smart food systems that utilize information and communication technology, which allow home cooks to explore information on convenience foods that match their preferences and enable food providers to offer food that matches the specific tastes of home cooks. The regression results suggest this possibility.
Biocontrol efficacy of bay essential oil against housefly, Musca domestica (Diptera: Muscidae)
Authors: Chintalchere Jyoti M. , Dar Mudasir A. , Pandit Radhakrishna S. 
Published: February 2020

Abstract
Background
The synanthropic housefly, Musca domestica, augments the transmission of several detrimental diseases like cholera and avian flu. Consequently, during the last century, many physico-chemical methods including synthetic compounds have been applied for its control. But these methods have proven to be prohibitive due to their side effects and serious issues like resistance development, environmental contamination, and detrimental effects on non-target fauna. Therefore, in view of these objectives, we investigated the effects of bay essential oil (EO) against M. domestica.

Methods
The attractant/repellent assays were conducted by double choice technique. Different enzyme assays evaluating the effect of LC50 concentration of the tested essential oil on larval gut were taken into consideration. To determine the composition, the tested oil was subjected to GC-MS/MS analysis. Further, the morphological alterations caused by EO treatment to third instar larvae were observed in a Nova Nano SEM machine. Data was statistically analyzed by one-way ANOVA using Tukey’s test (p < 0.001). The LC50 and LC90 values were calculated by probit analysis.

Results
The adulticidal bioassay revealed significant effects with LC50 concentration as 43.03 mg/dm3 against the newly emerged adult flies while in larvicidal assay mortality was dose dependent showing maximum effect at LC50 0.0629 μg/cm2. The pupicidal activity was more effective at a dose of LD50 64.09 μl/0.25 L of air which either killed the pupae or caused deformity in the emerged adults. Likewise total sugar, protein, glycogen, and lipid contents of larvae were reduced after treatment with EO when compared with the normal larvae along with some gut enzymes. The EO reduced the acetylcholinesterase activity from 0.013 U/mg protein in normal larvae to 0.0093 U/mg protein after EO treatment. The GC-MS/MS analysis of the bay EO showed the abundance of myrcene, linalool, eugenol, chavicol, and anethole along with diterpenoid, geranylgeraniol. However, the insecticidal activity of tested EO might be majorly imparted by eugenol content. The FESEM analysis showed shrinkage of integument and distortion to intersegmental regions caused by the tested compound.

Conclusion
The present study concludes the significant efficacy of bay EO against M. domestica which could be employed to breakdown its population below threshold levels to prevent the menace of vector-borne diseases.
A new early Visean coral assemblage from Azrou-Khenifra Basin, central Morocco and palaeobiogeographic implications
Authors: Rodríguez Sergio , Somerville Ian D. , Cózar Pedro , Sanz-López Javier , Coronado Ismael , González Felipe , Said Ismail , El Houicha Mohamed 
Published: February 2020

AbstractA new early Visean coral assemblage has been recorded from turbidite facies in the southern part of the Azrou-Khenifra Basin, northwest of Khenifra, central Morocco. The newly discovered Ba Moussa West (BMW) coral fauna includesSiphonophyllia khenifrensesp. nov.,Sychnoelasma urbanowitschi,Cravenia lamellata,Cravenia tela,Cravenia rhytoides,Turnacipora megastomaandPleurosiphonella crustosa. The early Visean age of the coral assemblage is supported by foraminiferal and conodont data, with the recognition of the basal Visean MFZ9 Zone. This confirms that the first transgression in the Azrou-Khenifra Basin was during the earliest Visean. The allochthonous coral assemblage was recovered from coarse-grained proximal limestone debris flow and turbidite beds within a fault-bounded unit, lying to the west of a thrust syncline containing upper Visean limestones. No evidence exists of the former early Visean shallow-water platform from which the corals were derived. All other in situ platform carbonate rocks around the southern margin of the Azrou-Khenifra Basin are probably of late Visean (Asbian–Brigantian) age. The early Visean Ba Moussa West coral fauna can be compared with that at Tafilalt in eastern Morocco, as well as in other Saharian basins of Algeria. Many of the genera and species in the Ba Moussa West assemblage are identical to those in NW Europe, with which it must have had marine connections. The new rugose species described,Siphonophyllia khenifrense,is probably endemic to North Africa. Its ecological niche in NW Europe was occupied byS. cylindricaorS.aff.garwoodi.
Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions
Authors: Sabri Youssriah Yahia , Nossair Eman Zaki Bassyouni , Assal HebatAllah Hany , Wahba Hisham Samir 
Published: February 2020

Abstract
Background
Conducted studies showed that the ADC (apparent diffusion coefficient) values of malignant mediastinal lesions are significantly lower than those of benign lesions. Investigators determined cut-off ADC values to differentiate the two; concluding that ADC value is a promising noninvasive, imaging parameter that helps assess and characterize mediastinal tumors.
Taking this a step forward, the primary objective of our prospective study was to investigate the potential of DW-MRI (diffusion-weighted magnetic resonance imaging) to characterize malignant mediastinal lesions using their ADC values.
Thirty-three patients that underwent MRI of the chest with DWI and latter pathologically diagnosed with a malignant mediastinal lesion were included in this study. Lesions’ ADC values were measured and correlated with the histopathological results. The statistical significance of differences between measurements was tested using the one-way ANOVA (analysis of variance) test; p values equal to or less than 0.05 were considered significant.

Results
There was no statistically significant difference between the ADCmean values of the histopathological groups of lesions assessed with the overlap of their ADCmean values. The average ADCmean value of NHL (non-Hodgkin lymphoma) was evidently lower than that of HD (Hodgkin disease) with no overlap between their ADCmean values. DWI failed at characterizing one lesion in this study as a malignant tumor, namely an immature teratoma (germ-cell tumor). Again DWI could not be used to evaluate a mass, latter pathologically diagnosed as an angiosarcoma, because of its overall hemorrhagic nature showing no definite non-hemorrhagic soft tissue components. The aforementioned results did not differ considerably when minimum ADC was used instead of mean ADC.

Conclusion
There was no statistically significant difference between the ADC values of the malignant mediastinal lesions evaluated. However, regarding lymphoma subtypes, our limited sample study of lymphoma suggested a considerable difference between the ADC values of Hodgkin disease and non-Hodgkin lymphoma.
Carers' experiences of involuntary admission under mental health legislation: systematic review and qualitative meta-synthesis
Authors: Stuart Ruth , Akther Syeda Ferhana , Machin Karen , Persaud Karen , Simpson Alan , Johnson Sonia , Oram Sian 
Published: February 2020

Background
Carers are key providers of care and support to mental health patients and mental health policies consistently mandate carer involvement. Understanding carers' experiences of and views about assessment for involuntary admission and subsequent detention is crucial to efforts to improve policy and practice.

Aims
We aimed to synthesise qualitative evidence of carers' experiences of the assessment and detention of their family and friends under mental health legislation.

Method
We searched five bibliographic databases, reference lists and citations. Studies were included if they collected data using qualitative methods and the patients were aged 18 or older; reported on carer experiences of assessment or detention under mental health legislation anywhere in the world; and were published in peer-reviewed journals. We used meta-synthesis.

Results
The review included 23 papers. Themes were consistent across time and setting and related to the emotional impact of detention; the availability of support for carers; the extent to which carers felt involved in decision-making; relationships with patients and staff during detention; and the quality of care provided to patients. Carers often described conflicting feelings of relief coupled with distress and anxiety about how the patient might cope and respond. Carers also spoke about the need for timely and accessible information, supportive and trusting relationships with mental health professionals, and of involvement as partners in care.

Conclusions
Research is needed to explore whether and how health service and other interventions can improve the involvement and support of carers prior to, during and after the detention of family members and friends.
Attributable Causes of Cancer in Vietnam
Authors: Nguyen Thuy Phuong , Luu Hung N. , Nguyen Mai Vu Tuyet , Tran Mo Thi , Tuong Thuy Thi Van , Tran Chi Thi Du , Boffetta Paolo 
Published: February 2020

PURPOSE Vietnam is undergoing rapid socio-economic transition with an increasing cancer burden. The contribution of modifiable risk factors to cancers in Vietnam has not been studied. Therefore, we sought to evaluate the attributable causes of cancer in Vietnam. METHODS We reviewed the data on burden of cancer in Vietnam from 2 cancer registries in Hanoi and Ho Chi Minh City between 1995 and 2012. Next, we calculated the fractions of cancers occurring in 2018 attributable to established modifiable risk factors whose impact could be quantified. Data on exposure prevalence were obtained for the period from 2000 to 2010 from national sources wherever possible. RESULTS Cancer incidence in Vietnam has decreased slightly in both sexes. Cancer related to infectious agents decreased sharply, whereas cancer related to nutrition and metabolism has increased. In 2018, established carcinogens included in the analysis explained 47.0% of cancer burden in Vietnam. Chronic infections accounted for 29.1% of cancers (34.7% in men and 22.1% in women), tobacco smoking for 13.5% (23.9% in men and 0.8% in women), and alcohol drinking for 10.3%. Passive smoking was responsible for 8.8% of cancers in women. Other risk factors, including overweight or obesity, nulliparity, and low vegetable and fruit intake, accounted for < 1% of all cancers each. CONCLUSION Cancer incidence is slowly decreasing in Vietnam, and the causes of more than half of cancers remain unexplained. This result underlines the need for further epidemiologic and fundamental research. Our findings confirm the notion that controlling oncogenic infections and decreasing tobacco smoking are the most effective approaches to reduce the burden of cancer in Vietnam, but other risk factors, including alcohol drinking and diet, should not be neglected.
Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis
Authors: Ghanim Husam , Abuaysheh Sanaa , Hejna Jeanne , Green Kelly , Batra Manav , Makdissi Antione , Chaudhuri Ajay , Dandona Paresh 
Published: February 2020

Abstract

Context
Dapagliflozin and other SGLT2 inhibitors are known to increase hematocrit, possibly due to its diuretic effects and hemoconcentration.

Objective
Since type 2 diabetes is a proinflammatory state and since hepcidin, a known suppressor of erythropoiesis, is increased in proinflammatory states, we investigated the possibility that dapagliflozin suppresses hepcidin concentrations and thus increases erythropoiesis.

Design
Prospective, randomized, and placebo-controlled study.

Setting
Single endocrinology center.

Patients
Fifty-two obese type 2 diabetes patients.

Intervention
Patients were randomized (1:1) to either dapagliflozin (10 mg daily) or placebo for 12 weeks. Blood samples were collected before and after treatments and serum, plasma, and mononuclear cells (MNC) were prepared.

Main Outcome Measure
Hepcidin and other hematopoietic factors.

Results
Following dapagliflozin treatment, there was a significant fall in HbA1c and a significant increase in hemoglobin concentration and hematocrit. Dapagliflozin treatment significantly reduced circulating hepcidin and ferritin concentrations while causing a significant increase in levels of the hepcidin inhibitor, erythroferrone, and a transient increase in erythropoietin. Additionally, dapagliflozin increased plasma transferrin levels and expression of transferrin receptors 1 and 2 in MNC, while there was no change in the expression of the iron cellular transporter, ferroportin. Dapagliflozin treatment also caused a decrease in hypoxia-induced factor-1α expression in MNC while it increased the expression of its inhibitor, prolyl hydroxylase-2. There were no significant changes in any of these indices in the placebo group.

Conclusions
We conclude that dapagliflozin increases erythropoiesis and hematocrit through mechanisms that involve the suppression of hepcidin and the modulation of other iron regulatory proteins.
A renormalized HVT approach for a class of central potential wells
Authors: Efthimiou C. A. , Grypeos M. E. , Koutroulos C, G. , Oyewumi W. J. , Petridou Th. 
Published: February 2020

An investigation is carried out to consider a renormalized HVT approach in the context of s-power series expansions for the energy eigenvalues of a particle moving non-relativistically in a central potential well belonging to the class V(r)=−Df(rR), D>0 where f is an appropriate even function of x=r/R and the dimensionless quantity s = (h^2/2μDR)^{1/2} is assumed to be sufficiently small. Previously, the more general class of central potentials of even power series in r is considered and the renormalized recurrence relations from which the expansions of the energy eigenvalues follow, are derived. The s-power series of the renormalized expansion are then given for the initial class of potentials up to third order in s (included) for each energy-level Enl . It is shown that the renormalization parameter Κ enters the coefficients of the renormalized expansion through the state-dependent quantity a_{nl}χ^{1/2} =a_{nl}(1+K ((−d_1D)R^2))^{½}, a_{nl}=(2n+l+32). The question of determining χ is discussed. Our first numerical results are also given and the utility of potentials of the class considered (to which belong the well-known Gaussian and reduced Poschl- Teller potentials) in the study of single–particle states of a Λ in hypernuclei is pointed out.
Measurement of language laterality using functional transcranial Doppler ultrasound: a comparison of different tasks
Authors: Woodhead Zoe V.J. , Rutherford Holly A. , Bishop Dorothy V.M. 
Published: February 2020

Background: Relative blood flow in the two middle cerebral arteries can be measured using functional transcranial Doppler sonography (fTCD) to give an index of lateralisation as participants perform a specific task. Language laterality has mostly been studied with fTCD using a word generation task, but it is not clear whether this is optimal. Methods: Using fTCD, we evaluated a sentence generation task that has shown good reliability and strong left lateralisation in fMRI. We interleaved trials of word generation, sentence generation and list generation and assessed agreement of these tasks in 31 participants (29 right-handers). Results: Although word generation and sentence generation both gave robust left-lateralisation, lateralisation was significantly stronger for sentence generation. Bland-Altman analysis showed that these two methods were not equivalent. The comparison list generation task was not systematically lateralised, but nevertheless laterality indices (LIs) from this task were significantly correlated with the other two tasks. Subtracting list generation LI from sentence generation LI did not affect the strength of the laterality index. Conclusions: This was a pre-registered methodological study designed to explore novel approaches to optimising measurement of language lateralisation using fTCD. It confirmed that sentence generation gives robust left lateralisation in most people, but is not equivalent to the classic word generation task. Although list generation does not show left-lateralisation at the group level, the LI on this task was correlated with left-lateralised tasks. This suggests that word and sentence generation involve adding a constant directional bias to an underlying continuum of laterality that is reliable in individuals but not biased in either direction. In future research we suggest that consistency of laterality across tasks might have more functional significance than strength or direction of laterality on any one task.
Experience of courtesy stigma among relatives of individuals with schizophrenia – a qualitative study
Authors: Prokop-Dorner Anna , Flis Maria 
Published: February 2020

Cel pracyCelem badania było opisanie piętna doświadczanego przez osoby towarzyszące swoim krewnym chorującym na schizofrenię w Polsce.MetodaW badaniu zastosowano triangulację czterech technik jakościowych: obserwacji uczestniczącej, analizy danych zastanych, wywiadów eksperckich i pogłębionych. Zebrany materiał został przeanalizowany zgodnie z modelem zaproponowanym przez M.B. Milesa i A.M. Hubermana.WynikiRozwój schizofrenii u członka rodziny stanowi okoliczność wprowadzającą jego opiekunów w pole piętna. Bliscy krewni chorującego doświadczają dyskursywnej niewidoczności problemów zdrowia psychicznego, braku zrozumienia i empatii. Siatka stygmatyzujących przekonań na temat schizofrenii i psychiatrii oraz brak wskazówek społecznych jak postępować, prowadzą do rozwoju u opiekuna stałego poczucia niepewności i poczucia zagubienia. Błędne przekonania na temat zaburzeń psychicznych przekładają się na dystans i niechęć, których opiekunowie rodzinni doświadczają w relacjach z dalszymi krewnymi, sąsiadami czy znajomymi. Rozpowszechnienie nieprzychylnego dyskursu nt. chorób psychicznych stymuluje u opiekunów antycypację wykluczenia, wstyd i ukrywanie. Ponadto, opiekunowie w kontaktach z personelem psychiatrycznym często doświadczają lekceważenia ich potrzeb oraz pesymizmu terapeutycznego. Te komponenty pola piętna zagrażają realizacji tego, co ważne dla opiekunów i przyczyniają się do rozwoju ich pozycji niemocy.WnioskiArtykuł prezentuje wyniki pierwszego badania jakościowego poświęconego opisaniu piętna przeniesionego doświadczanego przez krewnych osób ze schizofrenią w Polsce i omawia wpływ stygmatyzującego charakteru tej choroby na życie opiekunów rodzinnych. Zrozumienie społecznego kontekstu towarzyszenia chorującym na schizofrenię jest konieczne do lepszego zaspokajania potrzeb opiekunów rodzinnych i wypracowania skuteczniejszych modeli współpracy między personelem medycznym a rodziną pacjenta.