bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyse De La DiversitÃ© De La ForÃªt ClassÃ©e dâ€™Orumbo-Boka (Centre De La CÃ´te dâ€™Ivoire)
Authors: Mada Doumbia , HervÃ© Roland Kouassi , Alain Serge Augustin Ambe , Jules Richard Nomel Gnagne , Kouakou Edouard Nâ€™guessan 
Published: September 2020

La forÃªt classÃ©e dâ€™Orumbo-boka comprend de nombreuses espÃ¨ces en son sein. Lâ€™Ã©tude dans cette forÃªt classÃ©e a pour but dâ€™Ã©valuer sa diversitÃ© floristique. Pour atteindre cet objectif, un inventaire a Ã©tÃ© rÃ©alisÃ© dans cette forÃªt. Cet inventaire a consistÃ© en des relevÃ©s de surfaces et des relevÃ©s itinÃ©rants dans tous les biotopes identifiÃ©s et rencontrÃ©s dans cette forÃªt classÃ©e et dans ses environs. A lâ€™issus de cet inventaire, 281 espÃ¨ces ont Ã©tÃ© recensÃ©es. Ces espÃ¨ces sont rÃ©parties en 195 genres et 72 familles. Les familles les plus fournies en espÃ¨ces sont les Fabaceae, les Malvaceae, les Euphorbiaceae, les Moraceae et les Apocynaceae. A travers lâ€™analyse de la diversitÃ© dans les biotopes, il en ressort que les forÃªts secondaire sont plus diversifiÃ©es et abritent plus dâ€™espÃ¨ces que les autres biotopes. Parmi ces espÃ¨ces, 87 espÃ¨ces Ã statut particulier ont Ã©tÃ© dÃ©nombrÃ©es. La prÃ©sence de ces derniÃ¨res est une raison suffisante pour la prise en compte de ces espaces fragiles.
The classified forest of Orumbo-boka includes many species within it. The purpose of the study in this classified forest is to assess its floristic diversity. To achieve this objective, an inventory was carried out in this forest. This inventory consisted of surface surveys and itinerant surveys for all biotopes identified and encountered in and around this classified forest. From this inventory, 281 species have been identified. These species are divided into 195 genera and 72 families. The most abundant families are the Fabaceae, Malvaceae, Euphorbiaceae, Moraceae and Apocynaceae. Through the analysis of diversity in biotopes, it emerges that secondary forests are more diverse and support more species than other biotopes. Of these species, 87 species of special status were counted. The presence of the latter is a sufficient reason for taking into account these fragile spaces.
Confirmation De SÃ©grÃ©gation, Au Moyen Du BC1, De Lâ€™un Des Deux Loci Codant Pour La Couleur Du Germe Chez Le Cocotier Nain Ã Abidjan (CÃ´te dâ€™Ivoire)
Authors: Daouda Sidibe , Auguste Emmanuel Issali , Baudouin Luc , Bourdeix Roland , Didier Paulin Sokouri , Doubi Serge Tra Bi , Simon-Pierre Nâ€™guetta Assanvo 
Published: September 2020

Pour confirmer la sÃ©grÃ©gation de lâ€™un des deux loci codant pour la couleur du germe chez les cocotiers nains, le Back cross 1 : NJM x (NJM x GOA+) a Ã©tÃ© rÃ©alisÃ© dans le cadre dâ€™un projet de cartographie du gÃ©nome du cocotier. Un donneur NJM x GOA+ (Nain jaune de Malaisie x Grand Ouest Africain+) et une receveuse NJM (Nain jaune de Malaisie) ont Ã©tÃ© impliquÃ©s dans le BC1. Les statistiques descriptives, le test U de Mann-Withney et le test du Khi-deux de conformitÃ© ont Ã©tÃ© appliquÃ©s. Pour un total de 1034 noix semences germÃ©es, les rÃ©sultats ont montrÃ© que sur 5 sÃ©grÃ©gations testÃ©es, seule la 1:1 vÃ©rifie la conformitÃ© des donnÃ©es observÃ©es Ã celles thÃ©oriques au seuil de risque de 5 %. Ceci suggÃ¨re que le couple dâ€™allÃ¨les Vert/Jaune codant pour lâ€™expression phÃ©notypique y affÃ©rente sÃ©grÃ©ge selon les lois de la gÃ©nÃ©tique classique. Ces rÃ©sultats sâ€™apparentent Ã ceux de Bourdeix. Fort malheureusement, son analyse gÃ©nÃ©tique Ã©tait sous-tendue par de nombreuses hypothÃ¨ses. De plus, les semences de noix Ã©taient issues de pollinisations libres de pieds dâ€™hybrides F1. Dans les deux cas, ce sont les germes issus des noix F2 germÃ©es qui ont Ã©tÃ© analysÃ©es. La sÃ©grÃ©gation 1 : 1 issu du BC1 : NJM x (NJM x GOA+) suggÃ¨re un contrÃ´le monofactoriel du marqueur vert/jaune. Ce marqueur pourrait Ãªtre introgressÃ© dans les gÃ©notypes dâ€™intÃ©rÃªt avant dâ€™Ãªtre utilisÃ©, par la suite, pour la sÃ©lection prÃ©coce en germoir.
To confirm the segregation of one of the two loci coding for the color of the germ in dwarf coconut palms, back cross 1: MYD x (MYD x WAT+) was carried out as part of a coconut genome mapping project. An MYD x WAT+ (Malayan Yellow Dwarf x West African Tall+) donor and an MYD (Malayan Yellow Dwarf) recipient were involved in BC1. Descriptive statistics, the Mann-Withney U test and the Chi-two conformance test were applied. For a total of 1034 seed nuts germinated, the results showed that out of 5 segregations tested, only the 1: 1 verifies the compliance of the observed data with the theoretical ones at the risk threshold of 5%. This suggests that the pair of Green / Yellow alleles encoding the related phenotypic expression segregates according to the laws of classical genetics. Those results are similar to those of Bourdeix. Unfortunately, his genetic analysis was underpinned by many hypotheses. In addition, the nut seeds were obtained from free pollination of F1 hybrid feet. In both cases, only germs from the germinated F2 nuts were analyzed. The 1:1 segregation from BC1: MYD x (MYD x WAT+) suggests a monofactorial control of the green / yellow marker. This marker could be moved into the interest of the genotypes before being used, thereafter, for early selection in the germinator.
Analytical and experimental study on shear performance of RCC beam elements reinforced with PSWC rebars: a comparative study
Authors: Wani Shoib Bashir , Gull Sarvat , Amin Ishfaq , Mohmood Ayaz 
Published: September 2020

Early distress in RCC (Reinforced Cement Concrete) structures in the recent times poses a major problem for the construction industry. It is found that in most of cases, distresses in reinforced concrete structures are caused by corrosion of rebar embedded in the concrete. The HYSD (High Yield Strength Deformed) rebars which are used to offer excellent strength properties is detrimental to durability due to action of ribs as stress concentrators. Nowadays, concept of PSWC rebars (plain surface with wave type configuration rebars, formerly known as C-bars/mild steel rebar with curvy profile) is emerging to have a compromise between strength and durability. This investigation assesses the flexural behaviour of RCC elements reinforced with PSWC rebars. The flexural performance of RC beams of size 1000mm x 150mm x 150mm reinforced with PSWC rebars at 4mm and 6mm deformation level was studied by conducting test as per IS 516-1959 under four point loading. The performance of PSWC bar reinforced elements are compared with beams reinforced with mild steel rebars, HYSD rebars with spiral and diamond rib configuration to assess the viability of PSWC rebars to replace conventional reinforcement. The test results are validated by numerical analysis with the help of ANSYS software. Totally 15 beams are subjected to flexure test and the performance evaluators are first crack load, deflection at first crack load, ultimate load carrying capacity, deflection at ultimate load, load-deflection behaviour, load-strain behaviour and failure pattern. It is found that PSWC rebars as reinforcement in concrete beams enhanced the ductile behaviour of beams as compared to conventional HYSD and mild steel rebar beams. The energy absorbing capacity has increased significantly for beams reinforced with PSWC rebars when compared with conventional HYSD and mild steel rebar beams. The load-deflection behaviour and failure mode of PSWC rebars reinforced concrete beams were found to be similar to that of high yield strength rebars irrespective of deformation level. The analytical investigation from ANSYS software gave good agreement with the experimental results. It is concluded that PSWC bar has the potential to replace conventional HYSD rebar. Further study needs to be done to optimize the profile level and stirrup locations; and usage with high concrete grade for effective exploitation.
Physical Stability and Sun Protection Factors Measurement of Sunscreen Preparations in Stress Storage Conditions Using Spectrophotometry
Authors: Wulandari Widi , Wasito Hendri , Susilowati Sri Sutji 
Published: September 2020

Background: Sunscreen preparations can be used effectively to absorb sunlight especially in the UV wave emission region. The stress condition during the storage of preparation may affect physical and chemical properties. This study aims to determine the effect of stress storage conditions on physical stability and Sun Protection Factor (SPF) values as the effectiveness of sunscreen preparations stored in three different temperatures.
Method : This experimental study was conducted with the selection of sunscreen samples and performing physical stability tests in termed of color observation, physical observation, pH value, spreading test, adhesive test, and SPF value measurement of sunscreen using spectrophotometry in lotion and gel dosage forms stored at room temperature (25◦C), low temperature (4◦C), and high temperature (40◦C).
Results: The results showed that the stress storage condition influenced the physical properties of the preparation in the form of adhesive property, spreading capacity, and significantly affect the SPF value of the sunscreen (p <0.05) after 14 days of storage.
Analisis Kualitatif Faktor-Faktor Pendukung Kepatuhan Pasien Infeksi dalam Menggunakan Antibiotik Sefiksim Setelah Masa Rawat Inap di Rumah Sakit Prof. Dr. Margono Soekarjo
Authors: Mahardika Elisa , Maharani Laksmi , Suryoputri Masita Wulandari 
Published: September 2020

Penggunaan antibiotik harus sesuai dengan regimen yang telah ditentukan dokter atau apoteker untuk mencegah resistensi. Pasien setelah masa rawat inap berpotensi pada masalah kepatuhan dalam penggunaan antibiotik. Penelitian ini bertujuan untuk mengeksplorasi faktor-faktor pendukung kepatuhan pasien infeksi dalam menggunakan antibiotik sefiksim setelah masa rawat inap di Rumah Sakit Prof. Dr. Margono Soekarjo. Penelitian dilakukan menggunakan metode non-experimental berdasarkan pada pendekatan kualitatif fenomenologis dengan cara wawancara mendalam (indepth interview). Wawancara dilakukan dua kali pada hari ke-7 setelah keluar dari rumah sakit dan satu minggu setelah wawancara pertama. Hasil wawancara dianalisis secara deskriptif dengan proses berfikir induktif. Hasil penelitian menunjukkan bahwa faktor-faktor pendukung kepatuhan pasien infeksi dalam meminum antibiotik sefiksim setelah masa rawat inap adalah keinginan untuk sembuh, informasi bahwa antibiotik harus dihabiskan, takut terjadi kekambuhan, diingatkan anggota keluarga, bentuk sediaan, kondisi kesehatan yang memburuk dan mengikuti saran dokter. Selain itu, didapatkan hasil bahwa pasien patuh meminum dan menghabiskan antibiotik sesuai aturan pakai. Pasien mendapat mendapat manfaat dari etiket yang membantunya dalam mengingat jam minum obat.
Pengobatan Berpotensi Tidak Tepat Berdasarkan Kriteria Beers 2015 Pada Pasien Geriatri di RSUD Prof. Dr. Margono Soekarjo
Authors: Nabilla Annisaa Ayu , Utami Esti Dyah , Mustikaningtias Ika 
Published: September 2020

Geriatri berpotensi mengalami pengobatan berpotensi tidak tepat atau potentially inappropriate medications (PIMs). Kriteria Beers 2015 merupakan kriteria untuk mengidentifikasi PIMs. Pengambilan sampel secara retrospektif dengan pengambilan sampel acak sederhana. Hasil penelitian menunjukkan pasien paling banyak berusia 75-90 tahun, jenis kelamin laki-laki, lama rawat <7 hari dengan polifarmasi ≥5 macam obat. Dari 97 pasien, sebanyak 93 mengalami kejadian PIMs dengan 261 kejadian PIMs. Obat yang dihindari adalah omeprazol (31,57%). Obat yang masih bisa digunakan dengan hati-hati adalah furosemid (45,68%). Obat yang membutuhkan penyesuaian dosis adalah ranitidin (11,11%). Interaksi obat yang paling banyak adalah ketorolak dengan metilprednisolon (42,85%) dengan kondisi gagal jantung dan ginjal (28,57%).
Hubungan Kelentukan dan Daya Ledak Otot Lengan Terhadap Ketepatan Smash Bolavoli
Authors: Asnaldi Arie 
Published: September 2020

Penelitian ini bertujuan untuk mengetahui tingkat hubungan dan kontribusi kelentukan dan daya ledak otot lengan terhadap ketepatan smash bolavoli. Populasi penelitian ini adalah adalah Siswa SMK N 1 Solok-Selatan yang berjumlah 28 orang. Pengambilan sampel dilakukan dengan cara purposive samplingyaitu pengambilan unsur sampel atas dasar pertimbangan tertentu yang berjumlah 21 orang putra. Pengumpulan data dilakukan dengan cara mengukur Kelentukan melalui tes Bridge-Up (Kayang)dan dayaledak otot lengan dengan test medicine ball put. Selanjutnya ketepatanSmash dilakukan dengan tes ketepatanSmash. Analisa data dan pengujian hipotesis 1 dan 2 menggunakan teknik analisis korelasi sederhana dan teknik analisis korelasi gandaselanjutnya analisis koefesien determinasi dengan taraf signifikan α = 0,05. Dari analisis data dapat diperoleh hasil: (1) Kelentukan memiliki kontribusi yang berarti terhadap ketepatan SmashSiswa SMK N 1 Solok-Selatan sebesar 29,70%. (2) Dayaledak otot lenganmemiliki kontribusi yang berarti terhadap ketepatan SmashSiswa SMK N 1 Solok-Selatan sebesar 41,22%. (3) Kelentukan dan daya ledak otot lengan memiliki kontribusi yang berarti secara bersama-sama terhadapketepatanSmashSiswa SMK N 1 Solok-Selatan sebesar 60,99%.
Community Engagement and Building Trust to Resolve Ethical Challenges during Humanitarian Crises: Experience from the CAGED Study
Authors: Yimer Getnet , Gebreyes Wondwossen , Havelaar Arie , Yousuf Jemal , McKune Sarah , Mohammed Abdulmuen , O’Mathúna Dónal 
Published: September 2020

Abstract
Background: According to the Internal Displacement Monitoring Centre report on global human displacement, Ethiopia has the highest number of newly displaced people forced to flee their homes. Displaced people have arrived in other regions, sometimes leading to conflict. Several regions in Ethiopia experience on-going ethnic tensions and violence between tribes, which leaves smallholder farmers suspicious of any outside activities in their locale, assuming other ethnic groups may harm them. Changes in the central Ethiopian government have also led to suspicion of non-local agencies. The Campylobacter Genomics and Enteric Dysfunction (CAGED) research project’s objective is to improve the incomes, livelihoods and nutrition of smallholder farmers and was conducted during this period of increasing violence. The project aims to assess the impact of reducing exposure to chicken excreta on young children’s gut health and growth. This paper does not report empirical findings from CAGED, but is part of a series that aims to identify challenges in humanitarian research and reports on mitigation strategies during this research. Discussion: This research is important to determine whether Campylobacter infection in chicken’s contributes to illness and stunting in children. However, violence against other researchers in different parts of Ethiopia led to mistrust and lack of engagement by the community with the researchers. Some reactions were so hostile that the team was fearful about returning to some households. As a result, the team designed strategies to respond, including establishing two types of community advisory boards. One used pre-existing village elder structures and another was composed of village youth. Data collection team members received training in principles of ethics, consent, and crisis management, and were provided on-going support from local and international principal investigators and the study’s ethics advisor.Conclusion: The hostility and mistrust led to fear among the data collectors. These and the resulting strategies to address them resulted in delays for the research. However, the interventions taken resulted in successful completion of the field activities. Moreover, the lessons learned from this project are already being implemented with other projects being conducted in various parts of Ethiopia.
Decolorization and Detoxification of Triphenylmethane Dyes by isolated endophytic fungus, Bjerkandera adusta SWUSI4 under non-nutritive conditions
Authors: Gao Tiancong , Qin Dan , Zuo Shihao , Peng Yajun , Xu Jieru , Yu Baohong , Song Hongchuan , Dong Jinyan 
Published: September 2020

Abstract
Biodecolorization by microorganisms is a potential treatment technique because of they seem to be environmentally safe. In the present study, the decolourization and detoxification of cotton blue, crystal violet, malachite green and methyl violet by endophytic fungi were investigated. Preliminary screening result indicated that SWUSI4, identified as Bjerkandera adusta, demonstrated the best decolorization for the four TPM dyes within 14 days. Furthermore, optimization result demonstrated the decolorization rate could reach above 90 % at 24 h by live cells of isolate SWUSI4 when 4 g biomass was added into 100 mL dyes solution with the concentration 50 mg/L and shaking (150 rpm) conditions. Moreover, decolorization mechanism analysis shows that the decolorization was caused by isolate SWUSI4 that mainly including both absorption of biomass and/or degradation of enzymes. Biosorption of dyes was attributed to binding to hydroxyl, amino, phosphoryl alkane, and ester-lipids groups based on fourier transform infrared (FTIR) analyses. The biodegradation potential of SWUSI4 was further suggested by the change of peaks in the Ultraviolet-visible (UV-vis) spectra and detection of manganese peroxidase and lignin peroxidase activities. Finally, the phytotoxicity test confirmed that TPM dyes toxicity of the treatment after by SWUSI4 was significantly lower than that before treatment. These results indicate that an endophytic SWUSI4 could be used as a potential TPM dyes adsorption and degradation agent, thus facilitating the study of the plant-endophyte symbiosis in the bioremediation processes.
Development of an Engineered Peptide Antagonist against Periostin to Overcome Doxorubicin Resistance in Breast Cancer
Authors: Oo Khine Kyaw , Kamolhan Thanpawee , Soni Anish , Thongchot Suyanee , Mitrpant Chalermchai , Thuwajit Chanitra , Thuwajit Peti 
Published: September 2020

Abstract
Background

Chemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote cancer progression including cell survival, metastasis, and chemoresistance. The main objective of this study was to develop an anti-PN peptide from the bacteriophage library to overcome PN effects in breast cancer (BCA) cells.

Methods

A twelve amino acids bacteriophage display library was used for biopanning against the PN active site. A selected clone was sequenced and analyzed for peptide primary structure. A peptide was synthesized and tested for the binding affinity to PN. PN effects including a proliferation, migration and a drug sensitivity test were performed using PN overexpression BCA cells or PN treatment and inhibited by an anti-PN peptide. An intracellular signaling mechanism of inhibition was studied by Western blot analysis. Lastly, PN expressions in BCA patients were analyzed along with clinical data.

Results

The results showed that a candidate anti-PN peptide was synthesized and showed affinity binding to PN. PN could increase proliferation and migration of BCA cells and these effects could be inhibited by an anti-PN peptide. There was significant resistance to doxorubicin in PN-overexpressed BCA cells and this effect could be reversed by an anti-PN peptide in associations with phosphorylation of AKT and expression of survivin. In BCA patients, serum PN showed a correlation with tissue PN expression but there was no significant correlation with clinical data.

Conclusions

This finding supports that anti-PN peptide is expected to be used in the development of peptide therapy to reduce PN-induced chemoresistance in BCA.
Could the methylation of RASSF1A be the potential epigenetic biomarker for nasopharyngeal carcinoma? – Systematic review and meta-analysis
Authors: Lao Thuan Duc , Thieu Hue Hong , Nguyen Dung Huu , Le Thuy Ai Huyen 
Published: September 2020

Abstract
Background: RASSF1A is a tumor suppressor gene. The methylation of RASSF1A has been reported to be associated with the nasopharyngeal tumorigenesis. However, the heterogeneity was high among different studies. This meta-analysis aimed to evaluate the value of RASSF1A methylation for diagnosing and early screening NPC. Methods: Relevant articles were identiﬁed by searching MEDLINE database. The frequency and Odds ratio (OR) were applied to estimate the effect of CDH-1 methylation based on random-/fix-effect models. A meta-analysis was performed by using MedCalc® software. The subgroup analyses were performed by test-method, ethnicity, source of NPC samples to determine likely sources of heterogeneity. Results: Total of 16 studies, included 1,548 samples: 1,095 samples from NPC samples, and 453 from non-cancerous samples, were enrolled in the meta-analysis. The overall frequency of RASSF1A methylation were 59.22% and 1.72% in case-group and control-group, respectively. By removing the poor relative studies, the heterogeneity was not observed among included studies. The association between the RASSF1A gene methylation and risk of NPC was also confirmed by calculating OR value of 37.74 (95%OR = 20.07-70.98) in fix-effect model (Q = 13.56, p = 0.48, I2 = 0.00, 95% CI = 0.00-52.19). Additionally, the significant association was also found between the methylation of RASSF1A gene and subgroups. Conclusion: This was the first meta-analysis provided scientific evidences to suggest the RASSF1A methylation was the potential diagnosis, prognosis and early screening biomarker for NPC.
Impact of concomitant systemic treatments on toxicity and intracerebral response after stereotactic radiotherapy for brain metastases&nbsp;
Authors: Guénolé Morgan , Lucia François , Bourbonne Vincent , Dissaux Gurvan , Reygagne Emmanuelle , Goasduff Gaëlle , Pradier Olivier , Schick Ulrike 
Published: September 2020

Abstract
Background: The aim of this study was to determine the safety and efficacy of fractionated stereotactic radiotherapy (SRT) in combination with systemic therapies (ST) for brain metastases (BM). Methods: 99 patients (171 BM) received SRT and concurrent ST (group 1) and 95 patients (131 BM) received SRT alone without concurrent ST (group 2). SRT was planned on a linear accelerator, using volumetric modulated arc therapy. All ST were allowed including chemotherapy (CT), immunotherapy (IT), targeted therapy (TT) and hormonotherapy (HT). Treatment was considered to be concurrent if the timing between the drug administration and SRT did not exceed 1 month. IT was used concurrently with SRT in 30 patients. Local control (LC), freedom for distant brain metastases (FFDBM), overall survival (OS) and radionecrosis (RN) were evaluated. Variables analyzed included histology, age, gender, diagnosis-specific Graded Prognostic Assessment score, recursive partitioning analysis score, number of BM, presence of extracranial metastases, tumor volume, Karnofsky performance status and the timing of ST. Results: After a median follow-up of 11.9 months (range 0.7-29.7), there was no significant difference between the two groups. However, patients who received concurrent IT had better 1-year LC, FFDBM and RN rate compared to patient who did not: 96% versus 78% (p=0.02), 76% versus 53% (p=0.004) and 80% versus 90% (p=0.03), respectively. In multivariate analysis, concurrent IT (p=0.022) and tumor volume <2.07cc (p=0.039) were significantly correlated with improvement of LC. The addition of IT to SRT compared to SRT alone was associated with an increased risk of RN (p=0.03).Conclusion: SRT delivered concurrently with IT improved LC, FFDBM, OS with a higher RN rate.