bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Fathering Interventions Acceptable to Veterans? A Needs and Preferences Survey
Authors: Primack Jennifer M , Thompson Matthew , Doyle Rachel , Battle Cynthia L 
Published: December 2019

Abstract

Introduction
Military deployments cause stress for both service members and their families. Returning Veterans often report significant trauma exposure, and experience increased stress and mental health problems following deployment. These factors can in turn increase family problems and parenting strain among Veterans who are parents, exacerbating mental health symptoms. Men are generally less likely to seek treatment for mental health problems, and male Veterans, in particular, report lower rates of mental health treatment use. Interventions that target fathering or parenting skills may be more acceptable and less stigmatizing to male Veterans while serving the dual function of improving parental relationships and reducing mental health symptoms. However, it is unclear whether Veteran fathers will engage in these services.

Materials and Methods
As a preliminary evaluation of the acceptability of fathering interventions, 50 returning Veteran fathers completed an anonymous survey designed to assess their needs and preferences regarding this type of service. All procedures were approved by the local Institutional Review Board and Research and Development Committee.

Results
Ninety-eight percent of participants reported experiencing at least one parenting issue either that started postdeployment or that got noticeably worse following postdeployment. The majority (86%) stated that they would be open to participating in a fathering program if offered.

Conclusions
Returning Veteran fathers demonstrate interest in and willingness to participate in fathering programs suggesting that parenting programs may be a way to engage Veterans in mental health care following deployment.
The Effect of Simulated Field Storage Conditions on Dental Restorative Materials for Military Field Use
Authors: Lemon David J , Chen Wen , Smith Trevor , Ford April A , Moffett Steven X , Hoyle Jeffrey T , Hamlin Nicholas J , Hwang Yoon Y 
Published: December 2019

Abstract

Introduction
Dental readiness, one critical component of medical readiness, is adversely impacted by dental emergencies. Many dental emergencies require restorative materials such as glass ionomers, resins, and zinc oxide eugenols to remedy them. The Authorized Dental Allowance List (ADAL) and Authorized Medical Allowance List (AMAL) contain the equipment and materials used by Navy dentists to treat Sailors and Marines. These supplies are subjected to harsh storage conditions on deployments. Much is known about how materials behave when stored at room temperature, but less is known about how their properties are affected after exposure to high temperatures and humidity. We subjected five dental restorative materials to storage in aggravated conditions, and then tested them to determine which products are more robust.

Materials and Methods
Unopened packages of Fuji Triage, Fuji IX GP (both GC America Inc., Alsip, Illinois), TPH Spectra ST Low Viscosity, Intermediate Restorative Material (both Dentsply Sirona, York, Pennsylvania), and Herculite XRV (Kerr Corporation, Orange, California) were exposed to 0, 5, or 10 days’ storage at 30–60°C with 95% relative humidity. After storage in these aggravated conditions, we tested the compressive strength, hardness, elastic modulus, flexural strength, flexural modulus, sorption, and solubility of each material.

Results
The physical properties of all materials were affected by storage in aggravated conditions, though the properties of some materials degraded more than others. Both glass ionomers, Fuji Triage (P = 0.0012) and Fuji IX GP (P = 0.0031), and the composite Herculite XRV (P = 0.0253) lost compressive strength after 5 or 10 days in aggravated conditions. The hardness values for all materials were affected (P &lt; 0.05) by the aggravated conditions, though the elastic modulus of TPH Spectra was not affected (P &gt; 0.05). None of the materials lost flexural strength (P &gt; 0.05) or had changes in their flexural modulus (P &gt; 0.05). The water sorption behavior of Fuji Triage (P = 0.0426) and Fuji IX GP (P = 0.0201) changed after 10 days of aggravated storage, and the solubility of all materials was altered by the harsh conditions.

Conclusion
Some materials degrade more than others in aggravated conditions. Both resin composite materials were more resistant to high temperatures and humidity levels than the glass ionomers tested. These changes in physical characteristics should be considered when reviewing or optimizing the ADAL/AMAL for different projected operational environments.
Addressing Inter-Rater Variability in the ASA-PS Classification System
Authors: Knuf Kayla M , Manohar Crystal M , Cummings Adrienne K 
Published: December 2019

Abstract

Introduction
The American Society of Anesthesiologists’ Physical Status (ASA-PS) Classification System was established to grade a patient’s physical status prior to surgery. The literature shows inconsistencies in the application of the ASA-PS classification among providers. The many uses of the ASA-PS class require reliable ASA-PS class designations between providers. While much literature illustrates the inconsistency, there is limited research on how to improve inter-rater agreement.

Material and Methods
Following an educational intervention targeted at medicine providers, a retrospective chart review was completed to determine the long-term impact of an educational intervention on ASA-PS class agreement among providers of different specialties. To assess the overall agreement between the data sets following the intervention, kappa statistics were calculated for the medicine and anesthesia data sets. These values were compared to the kappa statistics from a similar study completed prior to the educational intervention.

Results
Overall, the kappa score, or agreement, between medicine and anesthesia providers improved from the range generally accepted to indicate slight agreement to the range indicating moderate agreement.

Conclusions
While there was improvement in agreement following an education intervention, the agreement seen was not statistically significant. More research needs to be done to determine how to improve inter-rater reliability of the ASA-PS classification system with a focus on non-anesthesia providers.
Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model
Authors: Yamaguchi Izumi , Nakajima Kohei , Shono Kenji , Mizobuchi Yoshifumi , Fujihara Toshitaka , Shikata Eiji , Yamaguchi Tadashi , Kitazato Keiko , Sampetrean Oltea , Saya Hideyuki , Takagi Yasushi 
Published: December 2019

AbstractBackgroundAntitumor therapies targeting programmed cell death-1 (PD-1) or its ligand-1 (PD-L1) are used in various cancers. However, in glioblastoma (GBM), the expression of PD-L1 varies between patients, and the relationship between this variation and the efficacy of anti-PD-1 antibody therapy remains unclear. High expression levels of PD-L1 affect the proliferation and invasiveness of GBM cells. As COX-2 modulates PD-L1 expression in cancer cells, we tested the hypothesis that the COX-2 inhibitor celecoxib potentiates anti-PD-1 antibody treatment via the downregulation of PD-L1.MethodsSix-week-old male C57BL/6 mice injected with murine glioma stem cells (GSCs) were randomly divided into four groups treated with vehicle, celecoxib, anti-PD-1 antibody, or celecoxib plus anti-PD-1 antibody and the antitumor effects of these treatments were assessed. To verify the mechanisms underlying these effects, murine GSCs and human GBM cells were studied in vitro.ResultsCompared with that with each single treatment, the combination of celecoxib and anti-PD-1 antibody treatment significantly decreased tumor volume and prolonged survival. The high expression of PD-L1 was decreased by celecoxib in the glioma model injected with murine GSCs, cultured murine GSCs, and cultured human GBM cells. This reduction was associated with post-transcriptional regulation of the co-chaperone FK506-binding protein 5 (FKBP5).ConclusionsCombination therapy with anti-PD-1 antibody plus celecoxib might be a promising therapeutic strategy to target PD-L1 in glioblastoma. The downregulation of highly-expressed PD-L1 via FKBP5, induced by celecoxib, could play a role in its antitumor effects.
Three-Vessel Anastomosis for Direct Bihemispheric Cerebral Revascularization
Authors: Ravina Kristine , Yim Benjamin , Lam Jordan , Strickland Ben A , Carey Joseph N , Russin Jonathan J 
Published: December 2019

Abstract

BACKGROUND
In rare, complex cerebrovascular pathologies, patients may benefit from simultaneous revascularization of multiple arterial territories. Traditional strategies for these situations include the use of more than 1 interposition graft, multiple microvascular anastomoses, vessel reimplantations, and staged procedures.

OBJECTIVE
To improve upon traditional revascularization strategies by describing a novel 3-vessel microvascular anastomosis. This technique combines a side-to-side and an end-to-side anastomoses to facilitate simultaneous direct revascularization of 2 arterial territories in a single procedure, with a single donor vessel.

METHODS
We present an illustrative case of moyamoya angiopathy in which a 3-vessel anastomosis was performed in the interhemispheric fissure to simultaneously directly revascularize bilateral anterior cerebral artery (ACA) territories. A detailed step-by-step depiction of the anastomosis technique is provided. In the presented case, 3-vessel anastomosis was combined with a radial artery fascial flow-through free flap, allowing for an additional indirect revascularization.

RESULTS
Technical execution of the 3-vessel anastomosis was uncomplicated. The patency of the anastomosis providing direct bilateral ACA territory revascularization was demonstrated intra- and postoperatively.

CONCLUSION
With this report, we demonstrate technical feasibility of a novel 3-vessel anastomosis for direct 2 arterial territory revascularization This single-stage approach combines side-to-side and end-to-side techniques and has benefits over traditional revascularization techniques, as it is not deconstructive, requires only a single craniotomy and a single interposition graft, and does not require lengthy recipient artery dissection.
OCCUPATIONAL RADIATION PROCEDURES AND DOSES AMONG NURSES IN SOUTH KOREA
Authors: Jang Mi Ya , Lee Won Jin , Chun Byung Chul , Cha Eun Shil 
Published: December 2019

Abstract
This study investigated occupational radiation procedures and radiation exposures among nurses in South Korea. A total of 530 nurses were surveyed from 2012 to 2013, and the survey data were linked with the dosimetry data. Multiple regression analysis was used to identify the factors associated with radiation dose. The most frequent procedure performed by the nurses was interventional radiology, followed by fluoroscopy and routine X-ray. The average annual effective dose and the cumulative dose were 0.91 mSv and 4.66 mSv, respectively. Characteristics of nurses exposed to high radiation doses were male, completed graduate school or higher, first worked before 2000 and performing interventional procedures, nuclear medicine test and fluoroscopy. Performing nuclear medicine tests and interventional procedures had a significant positive association with high radiation exposure.
Treatment of Hypertrophic Burn and Traumatic Scars With a 2,940-nm Fractional Ablative Erbium-doped Yttrium Aluminium Garnet Laser: A Pilot Study
Authors: Wulkan Adam J. , Rudnick Ashley , Badiavas Evangelos , Waibel Jill S. 
Published: December 2019

BACKGROUND
In recent years, fractional ablative lasers at low density have proven to be the centerpiece in a multimodality approach to treating hypertrophic burn scars.

OBJECTIVE
To determine the safety and efficacy of fractional ablative erbium-doped yttrium aluminium garnet (Er:YAG) laser in the treatment of hypertrophic burn scars.

METHODS
Eleven patients received 3 fractional ablative Er:YAG laser to hypertrophic burn scars at 400 to 800 μm, density 11%, no coagulation, and single pass at 4-week intervals.

RESULTS
Overall, average improvement was noted to be 2.27 of 3 as determined by blinded observers. A significant improvement was noted in all measured parameters including dyschromia, atrophy hypertrophy, vascularity, and texture.

CONCLUSION
This is a pilot study showing the safety and efficacy of fractional ablative Er:YAG laser treatment is a safe and effective treatment modality in the treatment of hypertrophic scars.
Update on Direct Oral Anticoagulants in Atrial Fibrillation Patients Undergoing Cardiac Interventional Procedures: From Clinical Trials to Real-World Evidence
Authors: Melillo Enrico , Carbone Andreina , Rago Anna , Papa Andrea A. , D'. Onofrio Antonio , Nigro Gerardo , Golino Paolo , Russo Vincenzo 
Published: December 2019

Abstract:
Direct oral anticoagulants (DOACs) are considered a first-line therapy for long-term stroke prevention in patients with nonvalvular atrial fibrillation (AF) and high thromboembolic risk. The potential role of DOACs in cardiac interventional procedures is a pressing clinical question, considering the increasing number of procedures and the growing prevalence of patients in DOAC therapy. The aim of this review is to provide an update on available evidence about the clinical performance of DOACs in AF patients undergoing different interventional procedures (AF cardioversion and ablation, and percutaneous coronary and structural heart disease interventions) and to explore the possible role of DOACs as an alternative therapeutic strategy in cardiac interventional procedures among non-AF patients.
SUSPENDING TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION IN CASES OF FUTILITY
Authors: Wong David T. , Lambrou George N. , Loewenstein Anat , Pearce Ian , Okada Annabelle A. ,   on behalf of the Vision Academy Steering Committee
Published: December 2019

Purpose:
To provide guidance on the management of patients with neovascular age-related macular degeneration and its subtypes who respond poorly to anti–vascular endothelial growth factor (anti-VEGF) therapy, and to identify cases where suspending anti-VEGF treatment may be warranted.

Methods:
Through a literature review and the combined knowledge and clinical experience of retinal experts, the Steering Committee of the Bayer-sponsored Vision Academy developed an algorithm for determining when to suspend anti-VEGF treatment of neovascular age-related macular degeneration in cases of futility.

Results:
Consideration of factors that may cause suboptimal response to anti-VEGF therapy, such as undertreatment or misdiagnosis of the underlying condition, and factors that may preclude continued treatment, such as injection- or drug-induced complications, is necessary for adjusting treatment protocols in patients who respond poorly to anti-VEGF. If poor response to treatment persists after switching to an alternative anti-VEGF agent and no change in response is observed after withholding treatment for a predetermined period of time (“treatment pause”), anti-VEGF treatment may be considered futile and should be suspended.

Conclusion:
This publication introduces an algorithm to guide the management of neovascular age-related macular degeneration in patients showing poor response to anti-VEGF treatment and provides expert guidance for suspending anti-VEGF treatment in cases of futility.
Ab Interno Trabeculotomy: Key Prognostic Factors
Authors: Kuusniemi Arvi-Matti , Lindbohm Nina , Allinen Pasi , Koskinen Mira , Harju Mika 
Published: December 2019

Précis:
The preoperative factors associated with a decreased survival rate of ab interno trabeculotomy (AbIT) perfomed using a Trabectome in open-angle glaucoma were selective laser trabeculoplasty (SLT) performed previously and axial length (AL) over 23.82 mm.

Purpose:
The purpose of this study was to find preoperative factors that predict outcomes of AbIT by a Trabectome.

Materials and Methods:
This retrospective single-center cohort study involved consecutive patients with primary open-angle glaucoma and exfoliation glaucoma treated at Helsinki University Hospital with AbIT with preoperative intraocular pressure (IOP) ≥18 mm Hg and follow-up of at least 1 year. Success was defined as lowering of their IOP by at least 20% from baseline or reduction in glaucoma medications without any rise in IOP above baseline, and no subsequent glaucoma surgery.

Results:
Of the total 72 eyes of 67 patients, 51 eyes had exfoliation glaucoma and 21 had primary open-angle glaucoma. Mean preoperative IOP was 25.2±5.3 mm Hg, with a mean of 3.2±1.2 glaucoma medications. In the multivariable model, a history of preoperative SLT and higher preoperative AL had hazard ratios of 2.99 [95% confidence interval (CI): 1.26-7.10] and 1.53 (95% CI: 1.12-2.09) with statistical significance (P=0.013 and 0.007). The statistically significant cutoff point was 23.82 mm in AL in relation to the success rate, with success times taken into account (P<0.001). AL over 23.82 mm had hazard ratio of 5.75 (95% CI: 2.57-12.87, P<0.001).

Conclusion:
Previous SLT and AL over 23.82 mm reduce survival after AbIT.
Updated Guidelines for the Management of Acute Otitis Media in Children by the Italian Society of Pediatrics
Authors: Marchisio Paola , Bortone Barbara , Ciarcià Martina , Motisi Marco Antonio , Torretta Sara , Castelli Gattinara Guido , Picca Marina , Di Mauro Giuseppe , Bonino Marisa , Mansi Nicola , Varricchio Alfonso , Marseglia Gian Luigi , Cardinale Fabio , Villani Alberto , Chiappini Elena ,   the Italian Panel for the Management of Acute Otitis Media in Children
Published: December 2019

Background:In recent years, new information has been acquired regarding the diagnosis, treatment and prevention of acute otitis media (AOM). The Italian Pediatric Society, therefore, decided to issue an update to the Italian Pediatric Society guidelines published in 2010.Methods:The search was conducted on Pubmed, and only those studies regarding the pediatric age alone, in English or Italian, published between January 1, 2010 and December 31, 2018, were included. Each study included in the review was assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) methodology. The quality of the systematic reviews was evaluated using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2 appraisal tool. The guidelines were formulated using the GRADE methodology by a multidisciplinary panel of experts.Results:The importance of eliminating risk factors (passive smoking, environmental pollution, use of pacifier, obesity, limitation of day-care center attendance) and the promotion of breastfeeding and hygiene practices (nasal lavages) was confirmed. The importance of pneumococcal vaccination in the prevention of AOM was reiterated with regard to the prevention of both the first episode of AOM and recurrences. Grommets can be inserted in selected cases of recurrent AOM that did not respond to all other prevention strategies. Antibiotic prophylaxis is not recommended for the prevention of recurrent AOM, except in certain carefully selected cases. The use of complementary therapies, probiotics, xylitol and vitamin D is not recommended.Conclusions:The prevention of episodes of AOM requires the elimination of risk factors and pneumococcal and influenza vaccination. The use of other products such as probiotics and vitamin D is not supported by adequate evidence.
Rhinovirus C Is Associated With Severe Wheezing and Febrile Respiratory Illness in Young Children
Authors: Erkkola Riku , Turunen Riitta , Räisänen Kati , Waris Matti , Vuorinen Tytti , Laine Miia , Tähtinen Paula , Gern James E. , Bochkov Yury A. , Ruohola Aino , Jartti Tuomas 
Published: December 2019

Background:
Rhinovirus is the most common virus causing respiratory tract illnesses in children. Rhinoviruses are classified into species A, B and C. We examined the associations between different rhinovirus species and respiratory illness severity.

Methods:
This is a retrospective observational cohort study on confirmed rhinovirus infections in 134 children 3–23 months of age, who were enrolled in 2 prospective studies on bronchiolitis and acute otitis media, respectively, conducted simultaneously in Turku University Hospital, Turku, Finland, between September 2007 and December 2008.

Results:
Rhinovirus C is the most prevalent species in our study, and it was associated with severe wheezing and febrile illness. We also noted that history of atopic eczema was associated with wheezing.

Conclusions:
Our understanding of rhinovirus C as the most pathogenic rhinovirus species was fortified. Existing research supports the idea that atopic characteristics are associated with the severity of the rhinovirus C-induced illness.
Blood Perfusion in Rotational Full-Thickness Lower Eyelid Flaps Measured by Laser Speckle Contrast Imaging
Authors: Tenland Kajsa , Berggren Johanna V. , Dybelius Ansson Cu , Hult Jenny , Dahlstrand Ulf , Lindstedt Sandra , Sheikh Rafi , Malmsjö Malin 
Published: December 2019

Purpose:
Large upper eyelid defects can be repaired by rotational full-thickness lower eyelid flaps. The aim was to measure the blood perfusion in such flaps, and how it is affected by the length of the flaps, and the degree of rotation and stretching.

Methods:
Nine patients underwent the Quickert procedure for entropion repair in which a full-thickness eyelid flap of approximate width 0.5 cm and length 2 cm was dissected in the lower eyelid. This generates a full-thickness eyelid flap similar to that used to repair large upper eyelid defects. Perfusion was measured using laser speckle contrast imaging, before and after the flap was rotated 90° and 120°, and stretched using forces of 0.5, 1, and 2 N.

Results:
Blood perfusion decreased gradually from the base to the tip of the flap; being 75% of the reference value 0.5 cm from the base, 63% at 1.0 cm, 55% at 1.5, 23% at 1.75 cm, and 4% at 2.0 cm. Rotating the flaps by 90° or 120° had little effect on the perfusion. Stretching reduced the perfusion from 63% to 32% at 2 N, when measured at 1 cm. The combination of stretching and rotation did not lead to any further decrease.

Conclusions:
Blood perfusion in lower eyelid rotational flaps seems to be more sensitive to stretching than to rotation. Provided the flap is no longer than 1.5 cm, the perfusion will be greater than 20%, even when rotated, which should be sufficient for adequate survival and healing.