bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteoporosis in patients with rheumatoid arthritis: trends in the German National Database 2007–2017
Authors: Lindner Lisa , Callhoff Johanna , Alten Rieke , Krause Andreas , Ochs Wolfgang , Zink Angela , Albrecht Katinka 
Published: May 2020

AbstractOsteoporosis is a frequent comorbidity in rheumatoid arthritis (RA). Due to the improved treatment options for RA, we expect a long-term decrease in osteoporosis as an accompanying disease. Data from the German National Database (NDB) were used to investigate whether the frequency of osteoporosis has changed in the last 10 years. From 2007 to 2017, approximately 4000 patients were documented annually with data on therapy and comorbidity. The cross-sectional data were summarised descriptively. Age, sex, disease duration, disease activity and glucocorticoids were considered as influencing factors. The Cochrane-Armitage test for trend was used to test whether the frequency of osteoporosis at the first visit changed from 2007 to 2017. Osteoporosis frequency in RA patients (mean age 63 years, 75% female) decreased from 20% in 2007 to 6% in 2017 (p < 0.001). The decrease affected women (22% to 17%) and men (14% to 8%) in all age groups and both short-term (≤ 2-year disease duration: 9% to 3%) and long-term RA patients (> 10-year disease duration: 28% to 20%). Patients with high disease activity and patients who took glucocorticoids (GC) were more often affected by osteoporosis than patients in remission or without GC. Drug prophylaxis in patients without osteoporosis increased (20% to 41% without GC, 48% to 55% with GC). Men with GC received less prophylactic treatment than women (48% vs. 57% in 2017). In this cohort, osteoporosis in patients with RA is less frequently observed compared to former years. RA-specific risk factors for osteoporosis such as disease activity and GC therapy have declined but long-term GC use is still present. Assessment of osteoporosis in RA patients should be investigated more consistently by bone density measurement. Male RA patients still need to be given greater consideration regarding osteoporosis drug prophylaxis, especially when GC therapy is needed.
Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project
Authors: Aumueller Nicole , Gruszfeld Dariusz , Gradowska Kinga , Escribano Joaquín , Ferré Natalia , Martin Françoise , Poncelet Pascale , Verduci Elvira , ReDionigi Alice , Koletzko Berthold , Grote Veit 
Published: May 2020

Abstract
Purpose
We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood.

Methods
Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method.

Results
Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (− 0.14; 95% CI − 0.01, − 0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (− 1.67; 95% CI − 0.42, − 2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake.

Conclusion
Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease.

Clinical trial registry
ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1.
Prevalence of left ventricular systolic dysfunction in a typical outpatient pacemaker cohort
Authors: Schwerg Marius , Dreger Henryk , Stangl Karl , Leonhardt Volker , Melzer Christoph 
Published: May 2020

Abstract
Background
Right ventricular (RV) pacing is the standard treatment for symptomatic bradycardia. RV pacing is known to cause dyssyncrony. New treatment options like His bundle pacing enhance the focus on left ventricular dysfunction in patients with pacemakers.

Objectives
The aim of this cross-sectional study was to obtain a real-life picture of the patients in a representative cohort of outpatients with permanent pacemakers. The prevalence and causes of left ventricular dysfunction (LVD) were explored.

Methods
In total, 1869 patients of a pacemaker outpatient clinic were screened for left ventricular systolic dysfunction by transthoracic echocardiography. All patients were interviewed for symptoms and cardiologist care. Percentages of RV pacing and underlying cardiac disease were recorded.

Results
A left ventricular ejection fraction (LVEF) under 45% was found in 207 (11.1%) of all patients. Predictive factors for a reduced LVEF were a high pacing rate and long-term pacing. LVD due to RV pacing was diagnosed in 3.4% of all patients. Only 845 patients (45%) reported that they regularly visited a cardiologist.

Conclusion
There is a high prevalence of unknown LVD in a typical pacemaker cohort. Therefore, regular echocardiographic examinations should be performed in outpatients of pacemaker clinics.
Motherhood after cancer: fertility and utilisation of fertility-preservation methods
Authors: Goeckenjan Maren , Freis A. , Glaß K. , Schaar J. , Trinkaus I. , Torka S. , Wimberger P. , Germeyer A. 
Published: May 2020

Abstract
Purpose
Due to modern and individualised treatments, women at reproductive age have a high survival rate after cancer therapy. What are pregnancy and birth rates of women after cancer and how often do they use cryopreserved ovarian tissue or gametes?

Methods
From 2007 to 2015, 162 women aged 26.7 ± 6.9 years were counselled for fertility preservation at a single University Fertility Centre. A questionnaire study was performed in average 3 and 6 years after the diagnosis of cancer. The women were asked about their fertility, partnership, family planning, and pregnancy history. 72 women (51%) answered a written questionnaire in 2016. 59 women were reached again by phone in 2019 (82%).

Results
The preferred method of fertility preservation was ovarian tissue cryopreservation (n = 36, 50%); none of the women had ovarian hyperstimulation in order to cryopreserve oocytes. About 3 years after treatment, 37 women of 72 women (51%) of the women with a mean age of 29.9 years had a strong wish to conceive. 21/72 (29%) had actively tried to conceive after successful cancer treatment; eight women (11%) were already pregnant or had children. Six years after cancer diagnosis 16/59 (27%) women had ongoing anticancer treatment. 12/59 (20%) were pregnant or had children, while 39% (23/59) had no menstrual cycle. Only one woman used her cryopreserved ovarian tissue, but did not become pregnant.

Conclusion
After cancer and gonadotoxic treatment, women’s desire to have a child is substantial. In this study, the rate of spontaneous pregnancies and births was 20% 6 years after gonadotoxic therapies. Not every woman, however, has the opportunity to conceive: factors impairing fertility include ongoing cancer treatment or persistent disease, no partner, no menstrual cycle, as well as other reasons for infertility.
Effects of cocaine and levamisole (as adulterant) on the isolated perfused Langendorff heart
Authors: Gartz A. , Pawlik E. , Eckhardt J. , Ritz-Timme St. , Huhn R. , Mayer F. 
Published: May 2020

AbstractCocaine-related deaths occur regularly in forensic routine work. In cases in which the detected concentration of cocaine is rather low and other causes of death apart from intoxication can be ruled out, the question arises if adulterants of cocaine might have played a crucial role. In the present study, cardiac effects of cocaine, of the adulterant levamisole and of mixtures of both were evaluated using the isolated perfused Langendorff heart. While exposed to the substances, functional parameters heart rate, left ventricular pressure and coronary flow were documented. Relevant alterations of these parameters were found for cocaine as well as for levamisole. Exposing the hearts to a mixture of both resulted in a combination of these effects; the emergence of new alterations or an obvious aggravation were not detected. Nevertheless, the results imply that the consumption of cocaine adulterated with levamisole bares an increased risk for cardiac complications, especially in the presence of preexisting cardiac pathologies.
Degradation of pesticide Cartap in Padan 95SP by combined advanced oxidation and electro-Fenton process
Authors: Hoang Nguyen Tien , Holze Rudolf 
Published: May 2020

AbstractThe electro-Fenton process combined with a boron-doped diamond-positive electrode in a one-compartment cell has shown efficient degradation of Cartap (95% in Padan 95SP) by hydroxyl radicals (•OH) generated in the electro-Fenton and the electrochemical oxidation processes. The influence of added NaOCl in a pretreatment step, effects of H2O2 concentration, Fe2+-ion addition, presence of further metals acting as co-catalysts, and solution pH on the efficiency of Cartap degradation were studied. The concentration of Cartap was determined by UV-vis spectroscopy according to the 5,5-dithiobis-(2-nitrobenzoic acid) procedure. The efficiency reaches approximately 80% when measured as total carbon concentration decrease, even with increased concentrations of H2O2, Fe2+, or metal ions added as co-catalyst. This limitation is presumably due to recalcitrant intermediates, which cannot be destroyed by •OH.
A specialised delivery system for stratospheric sulphate aerosols (part 2): financial cost and equivalent CO2 emission
Authors:   DSE 16-02, de Vries I. E. , Janssens M. , Hulshoff S. J. 
Published: May 2020

AbstractTemporary stratospheric aerosol injection (SAI) using sulphate compounds could help avoid some of the adverse and irreversible impacts of global warming, but comprises many risks and uncertainties. Among these, the direct financial cost and carbon emissions of potential SAI delivery systems have hitherto received only modest attention. Therefore, this paper quantifies the initial and operating financial costs and initial and operating equivalent CO2 (CO2eq) emissions of the specialised aircraft-based SAI delivery system developed with relatively high-fidelity tools in part 1 of this series. We analyse an interval of operating conditions, within which we devote special attention to four injection scenarios outlined in part 1: Three scenarios where H2SO4 vapour is directly injected at several dispersion rates and one SO2 injection scenario. We estimate financial cost through Raymer’s adjustment of Rand Corporation’s Development and Production Costs for Aircraft (DAPCA) model, augmented by additional data. CO2eq emission is computed from existing data and the computed fuel consumption for each of the scenarios. The latter estimates include an emission weighting factor to account for non-CO2 aircraft combustion products at altitude. For direct H2SO4 injection, both financial cost and CO2eq emission are sensitive to the design dispersion rate. For scenarios where higher dispersion rates are achieved, the delivery system’s cost and CO2eq are relatively small compared with the presumed benefits of SAI. The most optimistic H2SO4 scenario is found to have a financial cost and CO2eq emission similar to that of SO2 injection, while potentially allowing for reductions in the annual mass of sulphur injected to achieve a target negative radiative forcing. The estimates of financial cost and CO2eq emission were subjected to sensitivity analyses in several key parameters, including aircraft operational empty weight, engine specific fuel consumption, fuel price and aerosol price. The results indicate that the feasibility of the considered scenarios is robust.
Historical roots of Judit Bar-Ilan’s research: a cited-references analysis using CRExplorer
Authors: Bornmann Lutz , Leydesdorff Loet 
Published: May 2020

AbstractJudit Bar-Ilan (JB) was an influential researcher in information science and scientometrics. She published more than 100 papers about different topics. We used the CRExplorer (see www.crexplorer.net) to investigate the historical roots of JB’s research. In this program, the N_TOP10 indicator is available. We applied this indicator to identify those publications which have been very frequently cited by JB during several citing years. These might be the publications by which JB was mostly influenced in her research. Our results show that the identified publications are seminal works in information science and scientometrics as well as methodologically oriented publications dealing with text or content analyses as well as influence or distance measures.
Drug-induced sleep endoscopy while administering CPAP therapy in patients with CPAP failure
Authors: Dieleman E. , Veugen C. C. A. F. M. , Hardeman J. A. , Copper M. P. 
Published: May 2020

Abstract
Study objectives
To study the pattern of upper airway collapse in patients with CPAP failure by performing DISE while administering CPAP therapy and to determine the reason for CPAP failure accordingly.

Methods
This observational retrospective study comprised 30 patients diagnosed with OSA and CPAP failure, who underwent DISE while administering CPAP therapy. During DISE, the upper airway was assessed with and without CPAP therapy using the VOTE classification. Additionally, a jaw thrust maneuver was performed, in order to mimic the effect of an additional mandibular advancement device (MAD) in combination with CPAP therapy. Consequently, the outcome of DISE was translated into a clinically relevant categorization.

Results
Eleven patients (37%) had a persistent anteroposterior (AP) collapse, including a collapse at velum, tongue base, or epiglottis level and multilevel collapse. Eight patients (27%) had a floppy epiglottis. Five patients (17%) had a persistent complete concentric collapse (CCC) and three patients had a persistent laryngeal collapse (10%). In three patients (10%), no airway collapse was found after CPAP administration.

Conclusions
Based on the results of the reported study, in most cases, the potential cause of CPAP failure can be determined by this new diagnostic method. Consequently, suggestions can be made for additional therapy.
Effects of a professional development program for teaching mathematics with technology on teachers’ beliefs, self-efficacy and practices
Authors: Thurm Daniel , Barzel Bärbel 
Published: May 2020

AbstractDigital technologies such as multi-representational tools have the potential to enhance the learning of mathematics. In light of this potential, there is a ubiquitous call to integrate such tools into mathematics teaching. However, these technologies are still underused. Teaching with technology is not an easy task and teacher competencies such as knowledge and beliefs are a decisive factor. Therefore, professional development is important to professionalize teachers and support them in using technology in meaningful ways. Despite this need, little is known about the efficacy of professional development programs for teaching mathematics with technology. This quantitative study investigated the efficacy of a half-year professional development program for teaching mathematics with technology, using the methodology of a quasi-experimental design, in Germany. We captured (i) teachers’ beliefs about teaching with technology, (ii) self-efficacy beliefs related to teaching with technology, (iii) epistemological beliefs and (iv) self-reported frequency of technology uptake with quantitative questionnaires in pre- and post-tests. The experimental group (n = 39) participating in the professional development program consisted of mostly novices in using technology for teaching mathematics. Propensity score matching was used to match this group with a control group of teachers (n = 38) who did not participate in the professional development program. The strongest impact of the professional development program was found on teacher’s technology-related beliefs. Frequency of technology use seemed to increase gradually in the experimental group during the professional development program. No effect of the professional development program was found on self-efficacy beliefs and epistemological beliefs. We conclude by deriving recommendations for designing professional development programs related to teaching with technology.
Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways
Authors: Koushki Khadijeh , Shahbaz Sanaz Keshavarz , Mashayekhi Kazem , Sadeghi Mahvash , Zayeri Zeinab Deris , Taba Mahdieh Yousefi , Banach Maciej , Al-Rasadi Khalid , Johnston Thomas P. , Sahebkar Amirhossein 
Published: May 2020

AbstractAtherosclerosis is one type of cardiovascular disease (CVD) in which activation of the NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most effective treatments for atherosclerosis is the use of statin medications. Recent studies have indicated that statins, in addition to their lipid-lowering effects, exert inhibitory and/or stimulatory effects on the NLRP3 inflammasome and TLRs. Some of the statins lead to activation of the inflammasome and subsequently cause secretion of IL-1β and IL-18. Thus, these actions may further aggravate the disease. On the other hand, some statins cause inhibition of the inflammasome or TLRs and along with lipid-lowering, help to improve the disease by reducing inflammation. In this article, we discuss these contradictory studies and the mechanisms of action of statins on the NLRP3 inflammasome and TLR pathways. The dose-dependent effects of statins on the NLRP3 complex are related to their chemistry, pharmacokinetic properties, and danger signals. Lipophilic statins have more pleiotropic effects on the NLRP3 complex in comparison to hydrophilic statins. Statins can suppress TLR4/MyD88/NF-ĸB signaling and cause an immune response shift to an anti-inflammatory response. Furthermore, statins inhibit the NF-ĸB pathway by decreasing the expression of TLRs 2 and 4. Statins are cost-effective drugs, which should have a continued future in the treatment of atherosclerosis due to both their immune-modulating and lipid-lowering effects.
Low-tension gas process in high-salinity and low-permeability reservoirs
Authors: Das Alolika , Nguyen Nhut , Nguyen Quoc P. 
Published: May 2020

AbstractPolymer-based EOR methods in low-permeability reservoirs face injectivity issues and increased fracturing due to near wellbore plugging, as well as high-pressure gradients in these reservoirs. Polymer may cause pore blockage and undergo shear degradation and even oxidative degradation at high temperatures in the presence of very hard brine. Low-tension gas (LTG) flooding has the potential to be applied successfully for low-permeability carbonate reservoirs even in the presence of high formation brine salinity. In LTG flooding, the interfacial tension between oil and water is reduced to ultra-low values (10−3 dyne/cm) by injecting an optimized surfactant formulation to maximize mobilization of residual oil post-waterflood. Gas (nitrogen, hydrocarbon gases or CO2) is co-injected along with the surfactant slug to generate in situ foam which reduces the mobility ratio between the displaced (oil) and displacing phases, thus improving the displacement efficiency of the oil. In this work, the mechanism governing LTG flooding in low-permeability, high-salinity reservoirs was studied at a microscopic level using microemulsion properties and on a macroscopic scale by laboratory-scale coreflooding experiments. The main injection parameters studied were injected slug salinity and the interrelation between surfactant concentration and injected foam quality, and how they influence oil mobilization and displacement efficiency. Qualitative assessment of the results was performed by studying oil recovery, oil fractional flow, oil bank breakthrough and effluent salinity and pressure drop characteristics.
Geochemical characteristics and genetic mechanism of the high-N2 shale gas reservoir in the Longmaxi Formation, Dianqianbei Area, China
Authors: Li Ji-Lin , Zhang Ting-Shan , Li Yan-Jun , Liang Xing , Wang Xin , Zhang Jie-Hui , Zhang Zhao , Shu Hong-Lin , Rao Da-Qian 
Published: May 2020

AbstractAs an important pilot target for shale gas exploration and development in China, the Longmaxi Formation shale in the Dianqianbei Area is characterized by high content of nitrogen, which severely increases exploration risk. Accordingly, this study explores the genesis of shale gas reservoir and the mechanism of nitrogen enrichment through investigating shale gas compositions, isotope features, and geochemical characteristics of associated gases. The high-nitrogen shale gas reservoir in the Longmaxi Formation is demonstrated to be a typical dry gas reservoir. Specifically, the alkane carbon isotope reversal is ascribed to the secondary cracking of crude oil and the Rayleigh fractionation induced by the basalt mantle plume. Such a thermogenic oil-type gas reservoir is composed of both oil-cracking gas and kerogen-cracking gas. The normally high nitrogen content (18.05%–40.92%) is attributed to organic matter cracking and thermal ammoniation in the high-maturity stage. Specifically, the high heat flow effect of the Emeishan mantle plume exacerbates the thermal cracking of organic matter in the Longmaxi Formation shale, accompanied by nitrogen generation. In comparison, the abnormally high nitrogen content (86.79%–98.54%) is ascribed to the communication between the atmosphere and deep underground fluids by deep faults, which results in hydrocarbon loss and nitrogen intrusion, acting as the key factor for deconstruction of the primary shale gas reservoir. Results of this study not only enrich research on genetic mechanism of high-maturity N2 shale gas reservoirs, but also provide theoretical guidance for subsequent gas reservoir resource evaluation and well-drilling deployment in this area.
Human-machine collaboration in online customer service – a long-term feedback-based approach
Authors: Graef Roland , Klier Mathias , Kluge Kilian , Zolitschka Jan Felix 
Published: May 2020

AbstractThe rising expectations of customers have considerably contributed to the need for automated approaches supporting employees in online customer service. Since automated approaches still struggle to meet the challenge to fully grasp the semantics of texts, hybrid approaches combining the complementary strengths of human and artificial intelligence show great potential for assisting employees. While research in Case-Based Reasoning (CBR) already provides well-established approaches, they do not fully exploit the potential of CBR as hybrid intelligence. Against this background, we follow a design-oriented approach and develop an adapted textual CBR cycle that integrates employees’ feedback on semantic similarity, which is collected during the Reuse phase, into the Retrieve phase by means of long-term feedback methods from information retrieval. Using a real-world data set, we demonstrate the practical applicability and evaluate our approach regarding performance in online customer service. Our novel approach surpasses human-based, machine-based, and hybrid approaches in terms of effectiveness due to a refined retrieval of semantically similar customer problems. It is further favorable regarding efficiency, reducing the average time required to solve a customer problem.