bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Diagnostic Approaches to Predicting Stroke Complications
Authors: M. Toshkenov E. , Rakhimboeva G. S. , Abdukodirov U. T. 
Published: February 2020

Introduction: This article provides a brief description of the possibility of using reversible cerebral vasoconstriction syndrome as a possible predictor of stroke development. As you know, the main subtypes of ischemic stroke are: atherothrombotic. Cardiogenic embolic, lacunar, hemodynamic, hemorheological. To date, the pathophysiological mechanisms of the development of stroke have not been fully studied, so the search for new diagnostic criteria that expand the clinical diagnosis of acute circulatory disorders remains an urgent issue in clinical neurology.
Materials and Methods: 36 patients aged 30 to 77 years (mean age 53.5 ± 11.4 years) were examined at the Department of Neurology of the ASMI. The diagnosis was made based on anamnestic information, the results of the clinical and neurological examination and MRI data in the T-1, T-2, T2-FLAIR, MPA modes.
Results: According to the results of the study, a mild stroke (NIHSS less than 7 points, Bartel index more than 75 points, mRS less than 2 points) was observed in 36% of subjects, moderate severity (NIHSS 7-14 points, Bartel index 70-60 points, mRS 2-3 points) in 52% of patients with severe severity (NIHSS more than 14 points, Barthel index less than 50 points, mRS - 4 points) in 12% of patients. In neurological status, in all patients, motor (contralateral hemiparesis or monoparesis and sensory disturbances in combination with impaired innervation of the facial and sublingual nerve were determined to vary degrees. Speech disorders in the form of aphasia and dysarthria, slightly expressed disorders of gnosis and praxis were also detected.
Conclusion: The most significant factors affecting the course and outcome of the disease in patients with stroke can be considered the presence of cerebral angiospasm.
Thermoresponsive Inverted Colloidal Crystal Hydrogel Scaffolds for Lymphoid Tissue Engineering
Authors: Kwak Jun‐Goo , Lee Jungwoo 
Published: February 2020

AbstractInverted colloidal crystal (ICC) hydrogel scaffolds represent unique opportunities in modeling lymphoid tissues and expanding hematopoietic‐lymphoid cells. Fully interconnected spherical pore arrays direct the formation of stromal networks and facilitate interactions between stroma and hematopoietic‐lymphoid cells. However, due to the intricate architecture of these materials, release of expanded cells is restricted and requires mechanical disruption or chemical dissolution of the hydrogel scaffold. One potent biomaterials strategy to release pore‐entrapped hematopoietic‐lymphoid cells without breaking the scaffolds apart is to transiently increase the dimensions of these materials using stimuli‐responsive polymers. Having this mindset, thermoresponsive ICC scaffolds that undergo rapid (<1 min) and substantial (>300%) diameter change over a physiological temperature range (4–37 °C) by using poly(N‐isopropylacrylamide) (PNIPAM) with nanogel crosslinkers is developed. For a proof‐of‐concept study, the stromal niche by creating osteospheroids, aggregates of osteoblasts, and bone chips is first replicated, and subsequently Nalm‐6 model hematopoietic‐lymphoid cells are introduced. A sixfold increase in cell count is harvested when ICC hydrogel scaffolds are expanded without termination of the established 3D stromal cell culture. It is envisioned that thermoresponsive ICC hydrogel scaffolds will enable for scalable and sustainable ex vivo expansion of hematopoietic‐lymphoid cells.
A Graphene‐Based Flexible Device as a Specific Far‐Infrared Emitter for Noninvasive Tumor Therapy
Authors: Yu Tingting , Hu Yimin , Feng Guanping , Hu Ke 
Published: February 2020

AbstractNoninvasive treatments are emerging as a promising strategy not only due to their non‐invasive nature, but also due to their additive effects to traditional radiotherapy and chemotherapy. Herein, specific far‐infrared rays generated from single‐layer, graphene‐based devices are applied to tumors as a novel noninvasive therapeutic strategy. In MDA‐MB‐231 breast cancer cell xenograft and metastasis models, irradiation generated from this flexible device reduces the rate of tumor growth and the number of metastatic nodules per lung by 42% and 55%, respectively. This result might be induced by the similarity between the emission spectra of the device and the absorption spectra of the living tissue. With its high energy conversion and safety, the graphene‐based device can serve as an adjuvant therapeutic instrument for combined tumor treatment.
Oxygen‐Deficient Blue TiO2 for Ultrastable and Fast Lithium Storage
Authors: Hao Zhongkai , Chen Qi , Dai Wenrui , Ren Yinjuan , Zhou Yin , Yang Jinlin , Xie Sijie , Shen Yanbin , Wu Jihong , Chen Wei , Xu Guo Qin 
Published: February 2020

AbstractDeveloping a titanium dioxide (TiO2)‐based anode with superior high‐rate capability and long‐term cycling stability is important for efficient energy storage. Herein, a simple one‐step approach for fabricating blue TiO2 nanoparticles with oxygen vacancies is reported. Oxygen vacancies can enlarge lattice spaces, lower charge transfer resistance, and provide more active sites in TiO2 lattices. As a result, this blue TiO2 electrode exhibits a highly reversible capacity of 50 mAh g−1 at 100 C (16 800 mA g−1) even after 10 000 cycles, which is attributable to the combination of surface capacitive process and remarkable diffusion‐controlled insertion revealed by the kinetic analysis. The strategy of employing oxygen‐deficient nanoparticles may be extended to the design of other robust semiconductor materials as electrodes for energy storage.
Dynamics of corn dry matter content and grain quality after physiological maturity
Authors: Parvej Md Rasel , Hurburgh Charles R. , Hanna H. Mark , Licht Mark A. 
Published: February 2020

AbstractDelayed corn (Zea mays L.) harvest after physiological maturity (PM) is a universal practice in the U.S. Corn Belt to reduce grain drying cost. However, corn yield is speculated to be lost due to kernel dry matter loss from seed respiration. We evaluated the impact of in‐field dry down on corn dry matter content and grain quality after PM at two locations in Iowa during 2016 and 2017. Each site‐year consisted of two planting dates and three hybrids where ears were collected six to eight times from PM to harvest. Regardless of site‐year and hybrid, grain moisture decreased and test weight increased linearly with harvest dates and plateaued, on average, at 118 g kg–1 moisture and 752 kg m–3 test weight. Test weight was strongly associated with grain moisture. The standard test weight of 722 kg m–3 coincided with calendar dates around the first to second week of October. Kernel weight was unchanged and ear loss from lodging was minimal across harvest dates but differed among hybrids for each harvest date. These differences were not influenced by hybrid relative maturity (RM). Grain protein, oil, and starch concentrations were almost unchanged between PM and harvest though they were affected by the main and/or interaction effects between harvest dates and hybrids for most site‐years. Results suggest that corn can be harvested at any time after PM without any dry matter and quality penalties and harvest should be done based on grain moisture and standard test weight to minimize in‐field grain loss.
Quality‐of‐life and olfaction changes observed with short‐term medical management of chronic rhinosinusitis
Authors: Thomas Andrew J. , Mace Jess C. , Ramakrishnan Vijay R. , Alt Jeremiah A. , Mattos Jose L. , Schlosser Rodney J. , Soler Zachary M. , Smith Timothy L. 
Published: February 2020

BackgroundPatients with chronic rhinosinusitis (CRS) commonly experience both reduced quality of life (QOL) and olfactory dysfunction (OD). Literature on the impacts of appropriate medical therapy (AMT) for CRS on QOL and OD is limited, and the focused design of these studies may limit their applicability to usual clinical practice.MethodsAdults with symptomatic CRS were prospectively enrolled (November 2016 to October 2018) into an observational, multi‐institutional study. Individualized AMT was initiated using standard practice according to evidence‐based guidelines. Endoscopy examination (Lund‐Kennedy), olfactory function (Sniffin’ Sticks) testing, and QOL survey responses (22‐item Sino‐Nasal Outcome Test [SNOT‐22], Questionnaire of Olfactory Disorders―Negative Statements [QOD‐NS]) were obtained at enrollment and follow‐up.ResultsBaseline measures demonstrated heterogeneity of QOL and OD. After an average of 7.8 weeks, within‐subject median SNOT‐22 total improved by 39.5% (n = 39, p < 0.001) relative to baseline, including 50% (p = 0.014) improvement for item #21, “Sense of smell/taste.” QOD‐NS improvement was also statistically significant (p = 0.044). Sniffin’ Sticks score relative improvement of 10.9% (n = 33, p = 0.109) was not statistically significant and lacked correlation with SNOT‐22 total scores (R = −0.247, p = 0.165) or QOD‐NS total scores (R = −0.016, p = 0.930), but correlated moderately with endoscopy score (R = −0.436, p = 0.018).ConclusionsParticipants with varied impacts of CRS, treated with individualized short‐term AMT, demonstrated significant improvements in CRS‐ and olfactory‐specific QOL measures, without corresponding improvement in clinically measured olfactory function. Olfactory function changes moderately correlated with endoscopy score changes, but lacked an association with QOL measurements.
Element‐Element‐Bindungsbildung durch Oxidation und Reduktion
Authors: Piesch Martin , Graßl Christian , Scheer Manfred 
Published: February 2020

AbstractDie Redoxchemie von [(Cp′′′Co)2(μ,η2:η2‐E2)2] (E=P (1), As (2); Cp′′′=1,2,4‐Tritertbutyl‐cyclopentadienyl) wurde untersucht. Beide Verbindungen können jeweils zweimal oxidiert bzw. reduziert werden. Auf diese Weise wurden die monokationischen Verbindungen [(Cp′′′Co)2(μ,η4:η4‐E4)][X] (E=P, X=BF4 (3 a), [FAl] (3 b), E=As, X=BF4 (4 a), [FAl] (4 b)), die dikationischen Verbindungen [(Cp′′′Co)2(μ,η4:η4‐E4)][TEF]2 (E=P (5), As (6)) und die monoanionischen Verbindungen [K(18‐c‐6)(dme)2][(Cp′′′Co)2(μ,η4:η4‐E4)] (E=P (7), As (8)) isoliert. Eine weitere Reduktion von 7 führt zum dianionischen Komplex [K(18‐c‐6)(dme)2][K(18‐c‐6)][(Cp′′′Co)2(μ,η3:η3‐P4)] (9), in dem sich der cyclo‐P4‐Ligand zu einem ketten‐artigen P4‐Liganden umlagert. Die weitere Reduktion von 8 lässt sich mittels eines Kaliumüberschusses unter Bildung von [K(dme)4][(Cp′′′Co)2(μ,η3:η3‐As3)] (10) und der Eliminierung einer As1‐Einheit erreichen. 10 stellt das erste Beispiel eines in einem Tripeldecker‐Komplex enthaltenen allylischen As3‐Liganden dar.
Polymer nanocomposites containing β‐Bi2O3 and silica nanoparticles: Thermal stability, surface topography and X‐ray attenuation properties
Authors: Jayakumar Sangeetha , Saravanan Thangavelu , Philip John 
Published: February 2020

AbstractSilicone polymer‐based nanocomposites containing β‐Bi2O3 nanoparticles with varying concentrations of silica nanoparticles are successfully prepared and characterized for thermal stability, surface topography, and X‐ray attenuation property. Of all the samples studied here, silicone polymer of higher density (S1) containing β‐Bi2O3 (50 wt%) and silica (0.025 wt%) nanoparticles is found to be thermally stable upto 424 and 375°C in argon and oxygen atmosphere, respectively. The atomic force microscopy image of top and cleaved surface of this nanocomposite exhibits an average roughness of 12 and 506 nm, respectively. It also exhibits the highest X‐ray attenuation property, among the samples analyzed here, against X‐rays of energies in the range of 30–66 keV. Therefore, S1 silicone polymer containing β‐Bi2O3 and silica (0.025 wt%) nanoparticles is a potential material for the development of lead‐free and X‐ray opaque aprons, gloves, thyroid collar, gonad shield, and so on.
Photocurable bulk epoxy resins based on resorcinol derivative through cationic polymerization
Authors: Nguyen Quoc‐Bao , Nguyen Nhu‐Hai , Rios de Anda Agustín , Nguyen Vu‐Hieu , Versace Davy‐Louis , Langlois Valérie , Naili Salah , Renard Estelle 
Published: February 2020

AbstractBio‐sourced epoxy resins from resorcinol diglycidyl ether (RDGE) have been obtained by using cationic photopolymerization under UV‐light exposure. The photoinduced bulk resin samples were characterized by three‐point bending tests, dynamic mechanical analysis, as well as differential scanning calorimetry analysis, and thermogravimetric analysis. The influence of processing parameters, that is, reactant contents, UV irradiation time, and postcuring conditions on the thermomechanical behavior has been pointed out. For instance, the flexural modulus of the most performing materials reaches 4.1 GPa with the flexural strength and the glass‐transition temperature of around 105 MPa and 99°C, respectively. Interestingly, our optimized protocol has led to the synthesis of new bio‐based materials with more valuable thermal and mechanical properties than those of thermocured materials obtained from petroleum‐based commercial epoxy resins. Focus has been given on processing parameters to optimize the final properties of the material and to open an interesting alternative for sustainable building materials.
Aberrant Salience? Brain Hyperactivation in Response to Pain Onset and Offset in Fibromyalgia
Authors: Hubbard Catherine S. , Lazaridou Asimina , Cahalan Christine M. , Kim Jieun , Edwards Robert R. , Napadow Vitaly , Loggia Marco L. 
Published: February 2020

ObjectiveWhile much brain research on fibromyalgia (FM) focuses on the study of hyperresponsiveness to painful stimuli, some studies suggest that the increased pain‐related brain activity often reported in FM studies may be partially explained by stronger responses to salient aspects of the stimulation rather than, or in addition to, the stimulation's painfulness. Therefore, this study was undertaken to test our hypothesis that FM patients would demonstrate elevated brain responses to both pain onset and offset—2 salient sensory events of opposing valences.MethodsThirty‐eight FM patients (mean ± SD age 46.1 ± 13.4 years; 33 women) and 15 healthy controls (mean ± SD age 45.5 ± 12.4; 10 women) received a moderately painful pressure stimulus to the leg during blood oxygen level–dependent (BOLD) functional magnetic resonance imaging. Stimulus onset and offset transients were analyzed using a general linear model as stick functions.ResultsDuring pain onset, higher BOLD signal response was observed in FM patients compared to healthy controls in dorsolateral and ventrolateral prefrontal cortices (DLPFC and VLPFC, respectively), orbitofrontal cortex (OFC), frontal pole, and precentral gyrus (PrCG). During pain offset, higher and more widespread BOLD signal response was demonstrated in FM patients compared to controls in frontal regions significantly hyperactivated in response to onset. In FM patients, some of these responses were positively correlated with pain unpleasantness ratings (VLPFC, onset; r = 0.35, P = 0.03), pain catastrophizing scores (DLPFC, offset; r = 0.33, P = 0.04), or negatively correlated with stimulus intensity (OFC, offset; r = −0.35, P = 0.03) (PrCG, offset; r = −0.39, P = 0.02).ConclusionOur results suggest that the increased sensitivity exhibited by FM patients in response to the onset and offset of painful stimuli may reflect a more generalized hypersensitivity to salient sensory events, and that brain hyperactivation may be a mechanism potentially involved in the generalized hypervigilance to salient stimuli in FM.
A Facile Carbon Quantum Dot‐Modified Reduction Approach Towards Tunable Sb@CQDs Nanoparticles for High Performance Sodium Storage
Authors: Liu Fei , Wang Yaping , Zhang Yifang , Lin Jiande , Su Qiong , Shi Junrong , Xie Xuefang , Liang Shuquan , Pan Anqiang 
Published: February 2020

AbstractAntimony (Sb) has considerable specific capacity as an anode material for sodium‐ion batteries. However, the large volume expansion during alloying/dealloying with Na+ leads to poor cycling stability. Herein, we report the synthesis of Sb@carbon quantum dots (Sb@CQDs) composite via a facile one‐step reduction approach at room temperature. CQDs can modify the nucleation and growth of Sb particles during the reduction process and thus tune the size of Sb. Sb@CQDs particles with size of ∼7 nm can relieve the volume expansion and reduce the diffusion distance for sodium ions. Moreover, the residual CQDs in the obtained composite enhance the electronic conductivity. Benefited from the modification of CQDs, the Sb@CQDs composite delivers high specific capacity of 635 mA h g−1 at 0.1 A g−1 and 334 mA h g−1 at 2 A g−1.
Analysis of thermoluminescence characteristics of a lithium disilicate glass ceramic using a nonlinear autoregressive with exogenous input model
Authors: Işik Esme , Toktamiş Hüseyin , Işik İbrahim 
Published: February 2020

AbstractDental ceramics because of their translucency exemplify the most biologically realistic restorative materials for aesthetic rehabilitation and can be used to estimate dose accumulated as a result of a nuclear accident or attack. In this study, lithium disilicate ceramic obtained from Vivadent Ivoclar, Turkey was studied for its thermoluminescence (TL) properties. The lithium disilicate glass ceramic was irradiated with a 90Sr–90Y β‐source from 10 Gy to 6.9 kGy and the results read on a Harshaw 3500 reader. The TL peak of lithium disilicate ceramic showed sublinearity in the range 12 Gy to 6 kGy. The area under the TL glow curve increased by about 25% by the end of 10th measurement cycle. Fading values were also considered after irradiation. Lithium disilicate ceramic samples underwent 37% fading after 1 h and 59% fading after 1 week. In addition to the experimental study, a software‐based simulation study was also undertaken using a MATLAB system identification tool. Experimental studies are generally time consuming and some materials used for experiments are very expensive. In this study, experimental, and simulation results were compared and produced almost the same outcome with a similarity of more than 98%.
Corporate voluntary greenhouse gas reporting: Stakeholder pressure and the mediating role of the chief executive officer
Authors: Chithambo Lyton , Tingbani Ishmael , Agyapong Godfred Afrifa , Gyapong Ernest , Damoah Isaac Sakyi 
Published: February 2020

AbstractThe study sheds light on the extent to which various stakeholder pressures influence voluntary disclosure of greenhouse gas (GHG) emissions and how the impact is explained and moderated chief executive officer (CEO) characteristics of 215 FTSE 350 listed U.K. companies for the year 2011. The study developed a classification of GHG emission disclosure based on the guidelines of GHG Protocol, Department for Environment, Food and Rural Affairs, and Global Framework for Climate Risk Disclosure using content analysis. Evidence from the study suggests that some stakeholder pressure (regulatory, creditor, supplier, customer, and board control) positively impacts on GHG disclosure information by firms. We found that stakeholder pressure in the form of regulatory, mimetic, and shareholders pressure positively influenced the disclosure of GHG information. We also found that creditor pressure also had a significant negative relationship with GHG disclosure. Although CEO age had a direct negative effect on GHG voluntary disclosure, its moderation effect on stakeholder pressure influence on GHG disclosure was only significant on regulatory pressure.
Study on the targeted therapy of oral squamous cell carcinoma with a plasmid expressing PE38KDEL toxin under control of the SERPINB3 promoter
Authors: Wu Jiang , Guo Qiong , Zhang Guoliang , Zhao Liying , Lv Yvguang , Wang Jiaqi , Liu Jiguang , Shi Wei 
Published: February 2020

AbstractOral squamous cell carcinoma (OSCC) has a poor prognosis and a high risk of recurrence. To improve the efficacy of OSCC therapy, it is of great significance to explore gene therapy for OSCC. The use of specific genes to regulate the targeted expression of suicide genes is a hot topic in gene therapy for cancer. The SERPINB3 gene is highly active in squamous cell carcinoma, but nearly undetectable or present at a low level in normal tissues. This specificity suggests that the SERPINB3 promoter can be used for targeted OSCC therapy. Pseudomonas aeruginosa secretes PE38KDEL, an exotoxin derivative, as a suicide gene used in gene therapy. A SERPINB3 promoter‐mediated PE38KDEL expression vector was created. The SERPINB3 gene expression was tested in different cell lines by RT‐qPCR and Western blotting, and the SERPINB3 promoter activity was detected by luciferase assay. The SERPINB3 promoter was more active in the TCA8113 cell line than in the other cell lines. The target therapeutic potential of the toxin vector pSERPINB3‐PE38KDEL was tested in the SERPINB3‐positive TCA8113 cell line, the SERPINB3‐negative MG63 cell line, and normal L02 cell line. The SERPINB3 gene was expressed at a high level in TCA8113 cells but a low level in MG63 and L02 cells. Transfection of the pSERPINB3‐PE38KDEL plasmid effectively inhibited the proliferation and invasion of TCA8113 cells and induced cell apoptosis, but no significant damage to MG63 and L02 cells was observed. The results of in vitro experiments indicated that the pSERPINB3‐PE38KDEL plasmid could be a promising strategy for targeted OSCC gene therapy.
Mn3+ Active Surface Site Enriched Manganese Phosphate Nano‐polyhedrons for Enhanced Bifunctional Oxygen Electrocatalyst
Authors: Chinnadurai Deviprasath , Nallal Muthuchamy , Kim Hee‐Je , Li Oi Lun , Park Kang Hyun , Prabakar Kandasamy 
Published: February 2020

AbstractManganese‐based electrocatalyst has a great attention for the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) applications, since the discovery of active centre in nature photosynthesis system. The Mn oxidation state optimization and structural defect engineering are essential to get a highly active Mn‐based catalytic materials. MnP showed a good water oxidation activity with a lower overpotential of 286 mV to reach the current density of 10 mA/cm2 and a Tafel slope of 76 mV/dec. Also, the electron transfer number calculated from both the rotating disk electrode and rotating ring‐disk electrode techniques is a quasi‐4 electron transfer process with an onset and halfwave potential of 0.998 V and 0.936 V vs RHE respectively. MnP achieved a higher limiting kinetic current of 5.7 mA/cm2 and a very low H2O2 yield of 1.6 %. Chronoamperometry and cyclic voltammetry studies confirmed the long‐term stability and durability of the prepared catalyst. The variance metrics ΔE [Ej10−Ej‐3] is used to estimate the overall activity from the potential difference between OER overpotential at 10 mA/cm2 and ORR kinetic current at 3 mA/cm2. MnP shows very low ΔE (0.58 V) which demonstrate an efficient bifunctional activity in ORR and OER reactions. This work might shed new light on the development of MnP based bifunctional oxygen electrocatalyst.