bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping evidence of collaboration between traditional health practitioners and biomedically trained healthcare professionals in the reduction of antimicrobial resistance in sub-Saharan Africa: A systematic scoping review protocol
Authors: MUSHEBENGE AGANZE GLOIRE-AIME , KADIMA MUKANDA Gedeon , MASHAMBA-THOMPSON TIVANI , NLOOTO MANIMBULU 
Published: February 2020

Abstract
Background The overuse of prescribed antimicrobials, concurrent use of both traditional medicine and prescribed antimicrobials has been shown to lead to antimicrobial resistance. The absence of collaboration between traditional health practitioners and biomedically trained healthcare professionals can contribute to antimicrobial resistance, treatment failure, overdose, toxicity and misadministration. This scoping review explores evidence on collaboration between traditional health practitioners and biomedically trained healthcare professionals in the reduction of antimicrobial resistance and treatment failure in bacterial and viral diseases. Methods/design We will search electronic databases such as Science Direct, Google scholar, PubMed, MEDLINE via EBSCOhost. We will also search reference lists of included studies. A two-stage mapping procedure will be carried out. Stage one (1) will consist of title, abstracts and full article screening, respectively. A piloted screening form guided by the defined eligibility criteria will be used. Stage two (2), data will be extracted from the included studies. Parallel screening and data extraction will be conducted by two reviewers. Mixed methods appraisal tool (MMAT) will be used to assess the quality of the included studies. NVIVO version 11 will be employed to aid pertinent thematic analysis. The outcomes of interest will be as follows: Primary outcome will be the prevention and the reduction of antimicrobial resistance. Secondary outcomes: Effective collaboration between traditional healthcare practitioners and biomedically healthcare professionals. Discussion This review anticipates uncovering pertinent publications reporting the evidence of collaboration between traditional health practitioners and biomedically trained healthcare professionals in the reduction of antimicrobial resistance in sub-Saharan Africa. The sum up of evidence acquired from the included studies will help guide for future research. The result from the research will be print and electronically exposed.
Process performance and reuse potential of a decentralized wastewater treatment system
Authors: Ranjan Rajiv , Kumar Lokendra , Sabumon P. C. 
Published: February 2020

Abstract
The paper describes briefly the process performance and the reuse potential of a laboratory scale wastewater treatment system. The treatment involves enhanced primary treatment of Vellore Institute of Technology (VIT) campus sewage using ferric chloride as a coagulant, anaerobic digestion of coagulated organics, and biofilm aerobic process. The treated effluent after disinfection (using sunlight and chlorine) was used for irrigation of Tagetes erecta (marigold) plants and the plant growth parameters were evaluated for a life span of 3 months. In the primary treatment, an optimum ferric chloride dose of 30 mg/L could remove turbidity, chemical oxygen demand (COD), biochemical oxygen demand (BOD), and bacterial count (Escherichia coli) of 69%, 60%, 77%, and 55%, respectively. The coagulated organics could digest in a 25 L anaerobic reactor effectively with methane content in biogas varied between 50 and 60% and enhanced volatile suspended solids (VSS) reduction up to 70%. Sunlight based photo-oxidation followed chlorine disinfection saved 50% of the chlorine dose required for disinfection and treated effluent was fit for reuse. The results of growth parameters for Tagetes erecta plants indicate that anaerobically digested sludge is an excellent soil conditioner cum nutrient supplier. The results of this study exhibit a promising reuse potential of a decentralized wastewater treatment system and needs to be promoted for field scale applications.
Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications
Authors: Amiri Atefeh , Pourhanifeh Mohammad Hossein , Mirzaei Hamid Reza , Nahand Javid Sadri , Moghoofei Mohsen , Sahebnasagh Roxana , Mirzaei Hamed , Hamblin Michael R. 
Published: February 2020

:
Lung cancer is a malignancy with a high morbidity and mortality rate, and affected patients
have low survival and poor prognosis. The therapeutic approaches for the treatment of this cancer, including
radiotherapy and chemotherapy, are not particularly effective partly due to late diagnosis.
Therefore, the search for new diagnostic and prognostic tools is a critical issue. Novel biomarkers, such
as exosomes, could be considered as potential diagnostic tools for malignancies, particularly lung cancer.
Exosomes are nanovesicles, which are associated with different physiological and pathological
conditions. It has been shown that these particles are released from many cells, such as cancer cells,
immune cells and to some degree normal cells. Exosomes could alter the behavior of target cells
through intercellular transfer of their cargo (e.g. DNA, mRNA, long non-coding RNAs, microRNAs
and proteins). Thus, these vehicles may play pivotal roles in various physiological and pathological
conditions. The current insights into lung cancer pathogenesis suggest that exosomes are key players in
the pathogenesis of this cancer. Hence, these nanovesicles and their cargos could be used as new diagnostic,
prognostic and therapeutic biomarkers in the treatment of lung cancer. Besides the diagnostic
roles of exosomes, their use as drug delivery systems and as cancer vaccines is under investigation. The
present review summarizes the current information on the diagnostic and pathogenic functions of
exosomes in lung cancer.
Acute Myocarditis in Children: An Overview of Treatment and Recent Patents
Authors: Fung Ronald C.M. , Hon Kam L. , Leung Alexander K.C. 
Published: February 2020

Background:Pediatric myocarditis is rare but challenging. This overview summarized the current knowledge and recent patents on childhood myocarditis.Methods:Clinical queries and keywords of “myocarditis” and “childhood” were used as search engine.Results:Viral infections are the most common causes of acute myocarditis. Affected children often have a prodrome of fever, malaise, and myalgia. Clinical manifestations of acute myocarditis in children can be nonspecific. Some children may present with easy fatigability, poor appetite, vomiting, abdominal pain, exercise intolerance, respiratory distress/tachypnea, dyspnea at rest, orthopnea, chronic cough with wheezing, chest pain, unexplained tachycardia, hypotension, syncope, and hepatomegaly. Supraventricular arrhythmias, ventricular arrhythmias, and heart block may be present. A subset of patients have fulminant myocarditis and present with cardiovascular collapse, which may progress to severe cardiogenic shock, and even death. A high index of suspicion is crucial to its diagnosis and timely management. Cardiac magnetic resonance imaging is important in aiding clinical diagnosis while, endomyocardial biopsy remains the gold standard. The treatment consists of supportive therapy, ranging from supplemental oxygen and fluid restriction to mechanical circulatory support. Angiotensinconverting enzyme inhibitors, angio-tensin II receptor blockers, β-blockers, and aldosterone antagonists might be used for the treatment of heart failure while, immunosuppression treatments remain controversial. There are a few recent patents targeting prevention or treatment of viral myocarditis, including an immunogenic composition comprising a PCV-2 antigen, glutathione-S-transferase P1, neuregulins, NF-[kappa] B inhibitor, a pharmaceutical composition which contains 2-amino-2- (2- (4-octyl phenyl) - ethyl) propane 1,3-diol, a composition containing pycnojenol, Chinese herbal concoctions, and a Korean oral rapamycin. Evidence of their efficacy is still lacking.Conclusions:This article reviews the current literature regarding etiology, clinical manifestations, diagnosis, and management of acute myocarditis in children.
Faktor-faktor yang mempengaruhi penyelesaian masa studi program pascasarjana di Institut Pertanian Bogor
Authors: Yuniar Dina , Mulyati Heti , Cahyadi Eko Ruddy 
Published: February 2020

Rata-rata penyelesaian masa studi program magister Sekolah Pascasarjana di Institut Pertanian Bogor kurang dari dua tahun (17,5%). Oleh karena itu, faktor-faktor yang mempengaruhi baik dari aspek internal maupun eksternal perlu dikaji. Faktor internal berasal dari dalam diri mahasiswa yang meliputi kemampuan akademik dan motivasi. Faktor eksternal mencakup faktor lingkungan dan pembimbing saat menyelesaikan tugas akhir. Pengambilan data dan informasi menggunakan instumen kuesioner yang terstruktur terhadap lulusan program magister. Analisis menggunakan analisis deskriptif, analisis faktor, dan regresi linier berganda. Penyelesaian masa studi meliputi faktor-faktor kualitas pembimbingan, pelayanan dan lingkungan, kemampuan mahasiswa, motivasi, responsif serta gelar dan prestis. Analisis lebih lanjut menunjukkan penyelesaian masa studi sangat terkait dengan faktor-faktor eksternal yang berasal dari luar seperti layanan pendidikan dan faktor lingkungan, di antaranya lingkungan kampus yang bersih dan hijau, lingkungan belajar yang tenang dan nyaman. Responsif terhadap feedback dari pembimbing untuk segera memperbaiki tesis secara intens dan tepat waktu merupakan faktor internal.Kata kunci: masa studi, perguruan tinggi, eksternal, internal, analisis faktor Factors on completing study of master students in graduate schoolAbstractCompletion of the final assignment of the Postgraduate school master's program at the Institut Pertanian Bogor on average less than two years (17,5%). This is the purpose of the research, namely to see the factors that influence the completion of the final task. The factors that influence the study period consist of internal and external factors. Internal factors originating from within the student themselves include academic ability and motivation. External factors come from outside such as environmental factors and mentors when completing the final task. Retrieval of data and information in this study using a structured questionnaire instrument for graduates of the Institute Pertanian Bogor University's Graduate School Masters program. The analysis uses descriptive analysis, factor analysis, and multiple linear regression. Completion of the study period includes factors of coaching quality, service, and environment, student ability, motivation, responsiveness and degree, and prestige. Further analysis shows that the completion of studies is closely related to external factors originating from outside such as education services and environmental factors, including a clean and green campus environment, a quiet and comfortable learning environment. Responsiveness to feedback from the counselor to immediately correct the thesis in an intense and timely manner is internal.Keywords: complete a study, postgraduate, external, internal, factor analysis
Pendekatan relasi antar etnis untuk meningkatkan rasa solidaritas kebangsaan siswa SMA dalam pembelajaran sejarah
Authors: Pambudi Wahyu , Sariyatun Sariyatun , Musadad Akhmad Arif 
Published: February 2020

Penelitian ini bertujuan untuk mengembangkan model pembelajaran sejarah Indonesia di SMA yang didesain dengan pendekatan relasi antar etnis dan mengevaluasi pengaruhnya terhadap peningkatkan rasa solidaritas kebangsaan siswa. Penelitian dilakukan menggunakan metode penelitian dan pengembangan (research and development, - R & D) sesuai prosedur Borg & Gall (2003). Subyek penelitian ini adalah siswa SMAN 1 Kota Kediri. Pengumpulan data menggunakan teknik dokumentasi, observasi dan angket. Analisis data statistik parametrik menggunakan bantuan program SPSS for windows versi 22.0. Hasil pengembangan menunjukkan bahwa model pembelajaran sejarah Indonesia berbasis relasi antar etnis (RAE) layak untuk diimplementasikan. Uji efektifitas model dengan teknik uji-t antar kelompok menunjukkan hasil t. 2,398, dengan taraf sig. 0,019 yang berarti model pembelajaran RAE efektif untuk meningkatkan rasa solidaritas kebangsaan siswa AbstractThis research aims to develop a learning model of Indonesian history at senior high school which is designed by correlation approach among the ethnics and to evaluates the effect toward the improvement of students’ national solidarity. The research was conducted by using research and development methods (R&D) according to Borg & Gall procedure (2003). The research subject was students of SMAN 1 Kediri City. The data collection used techniques of documentation, observation, and questionnaire. Data analysis of parametric statistics used program SPSS for Windows version 22.0. The result of development showed that the learning model of Indonesian history with inter ethnics correlation (IEC) based is feasible to be implemented. The effectiveness test of the model was by independent samples t-test technique showed the result t. 2,398 with sig. value 0,019, which means learning model CIE, is effective to improve students’ national solidarity.
Penerapan model pembelajaran group investigation untuk meningkatkan hasil belajar Ilmu Pengetahuan Sosial
Authors: Pratami Azmi Zakiyya , Suhartono Suhartono , Salimi Mohammad 
Published: February 2020

Tujuan penelitian ini, yaitu: 1.) Mendeskripsikan penerapan model pembelajaran group investigation; 2.) Meningkatkan hasil belajar IPS; dan 3.) Mendeskripsikan kendala dan solusi dalam penerapan model pembelajaran group investigation. Penelitian ini merupakan penelitian tindakan kelas kolaboratif. Subjek penelitian ini adalah guru dan siswa kelas IV SD Negeri 6 Panjer tahun ajaran 2018/2019 yang berjumlah 24 siswa. Data yang digunakan berupa data kualitatif yaitu penerapan model pembelajaran group investigation dan data kuantitatif yaitu hasil belajar IPS tema cita-citaku. Teknik pengumpulan data menggunakan observasi, wawancara, dan tes. Hasil penelitian menunjukkan bahwa: 1.) Model group investigation diterapkan dengan langkah: membentuk kelompok, mengidentifikasi topik, merencanakan investigasi, melaksanakan investigasi, menyiapkan laporan akhir, mempresentasikan laporan akhir, dan evaluasi; 2.) Hasil belajar IPS pada tema cita-citaku meningkat. Pada siklus I hingga siklus III angka hasil belajar mengalami peningkatan yang signifikan; dan 3.) Kendala yang ditemui antara lain: siswa kesulitan untuk mencari informasi dari sumber. Kesimpulan penelitian ini adalah penerapan model pembelajaran group investigation dapat meningkatkan hasil belajar IPS pada tema cita-citaku. AbstractThe purpose of this study, namely: 1.) Describes the application of the group investigation learning model; 2.) Improving social studies learning outcomes on the theme of my ideals; and 3.) Describing the constraints and solutions in applying the group investigation learning model. This research is collaborative classroom action research. The subjects of this study were teachers and fourth grade students of SD Negeri 6 Panjer 2018/2019 academic year, totaling 24 students. The data used in the form of qualitative data, namely the application of the group investigation learning model and quantitative data, namely the results of social studies learning theme my goal. Data collection techniques used observation, interviews, and tests. The results of this study indicate that: 1.) The investigation group model is applied by steps: forming groups, identifying topics, planning investigations, carrying out investigations, preparing final reports, presenting final reports, and evaluating; 2.) Social studies learning outcomes on the theme of my dreams are increasing. In the first cycle till third cycle always be advance significantly; and 3.) obstacles encountered include: students having difficulty finding information from sources. The conclusion of this study is the application of the Group investigation learning model can improve social studies learning outcomes on the theme of my dreams.
Distributed Regression Analysis Application in Large Distributed Data Networks: Analysis of Precision and Operational Performance
Authors: Her Qoua , Malenfant Jessica , Zhang Zilu , Vilk Yury , Young Jessica , Tabano David , Hamilton Jack , Johnson Ron , Raebel Marsha , Boudreau Denise , Toh Sengwee 
Published: February 2020

Background
A distributed data network approach combined with distributed regression analysis (DRA) can reduce the risk of disclosing sensitive individual and institutional information in multicenter studies. However, software that facilitates large-scale and efficient implementation of DRA is limited.

Objective
This study aimed to assess the precision and operational performance of a DRA application comprising a SAS-based DRA package and a file transfer workflow developed within the open-source distributed networking software PopMedNet in a horizontally partitioned distributed data network.

Methods
We executed the SAS-based DRA package to perform distributed linear, logistic, and Cox proportional hazards regression analysis on a real-world test case with 3 data partners. We used PopMedNet to iteratively and automatically transfer highly summarized information between the data partners and the analysis center. We compared the DRA results with the results from standard SAS procedures executed on the pooled individual-level dataset to evaluate the precision of the SAS-based DRA package. We computed the execution time of each step in the workflow to evaluate the operational performance of the PopMedNet-driven file transfer workflow.

Results
All DRA results were precise (<10−12), and DRA model fit curves were identical or similar to those obtained from the corresponding pooled individual-level data analyses. All regression models required less than 20 min for full end-to-end execution.

Conclusions
We integrated a SAS-based DRA package with PopMedNet and successfully tested the new capability within an active distributed data network. The study demonstrated the validity and feasibility of using DRA to enable more privacy-protecting analysis in multicenter studies.
Using Complexity Assessment to Inform the Development and Deployment of a Digital Dashboard for Schizophrenia Care: Case Study
Authors: Gremyr Andreas , Andersson Gäre Boel , Greenhalgh Trisha , Malm Ulf , Thor Johan , Andersson Ann-Christine 
Published: February 2020

Background
Health care is becoming more complex. For an increasing number of individuals, interacting with health care means addressing more than just one illness or disorder, engaging in more than one treatment, and interacting with more than one care provider. Individuals with severe mental illnesses such as schizophrenia are disproportionately affected by this complexity. Characteristic symptoms can make it harder to establish and maintain relationships. Treatment failure is common even where there is access to effective treatments, increasing suicide risk. Knowledge of complex adaptive systems has been increasingly recognized as useful in understanding and developing health care. A complex adaptive system is a collection of interconnected agents with the freedom to act based on their own internalized rules, affecting each other. In a complex health care system, relevant feedback is crucial in enabling continuous learning and improvement on all levels. New technology has potential, but the failure rate of technology projects in health care is high, arguably due to complexity. The Nonadoption, Abandonment, and challenges to Scale-up, Spread, and Sustainability (NASSS) framework and complexity assessment tool (NASSS-CAT) have been developed specifically to help identify and manage complexity in technology-related development projects in health care.

Objective
This study aimed to use a pilot version of the NASSS-CAT instrument to inform the development and deployment of a point-of-care dashboard supporting schizophrenia care in west Sweden. Specifically, we report on the complexity profile of the project, stakeholders’ experiences with using NASSS-CAT, and practical implications.

Methods
We used complexity assessment to structure data collection and feedback sessions with stakeholders, thereby informing an emergent approach to the development and deployment of the point-of-care dashboard. We also performed a thematic analysis, drawing on observations and documents related to stakeholders' use of the NASSS-CAT to describe their views on its usefulness.

Results
Application of the NASSS framework revealed different types of complexity across multiple domains, including the condition, technology, value proposition, organizational tasks and pathways, and wider system. Stakeholders perceived the NASSS-CAT tool as useful in gaining perspective and new insights, covering areas that might otherwise have been neglected. Practical implications derived from feedback sessions with managers and developers are described.

Conclusions
This case study shows how stakeholders can identify and plan to address complexities during the introduction of a technological solution. Our findings suggest that NASSS-CAT can bring participants a greater understanding of complexities in digitalization projects in general.