bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired actin dynamics and suppression of Shank2-mediated spine enlargement in cortactin knockout mice
Authors: Tanaka Shinji , Masuda Yasutaka , Harada Akihiro , Okabe Shigeo 
Published: January 2020

Abstract
Cortactin regulates actin polymerization and stabilizes branched actin network. In neurons, cortactin is enriched in dendritic spines that contain abundant actin polymers. To explore the function of cortactin in dendritic spines, we examined spine morphology and dynamics in cultured neurons taken from cortactin knockout (KO) mice. Histological analysis revealed that the density and morphology of dendritic spines were not significantly different between wild-type (WT) and cortactin KO neurons. Time-lapse imaging of hippocampal slice cultures showed that the extent of spine volume change was similar between WT and cortactin KO neurons. Despite little effect of cortactin deletion on spine morphology and dynamics, actin turnover in dendritic spines was accelerated in cortactin KO neurons. Furthermore, we detected a suppressive effect of cortactin KO on spine head size under the condition of excessive spine enlargement induced by overexpression of a prominent postsynaptic density protein Shank2. These results suggest that cortactin may have a role in maintaining actin organization by stabilizing actin filaments near the postsynaptic density.
Explaining How Human Rights Protections Change After Internal Armed Conflicts
Authors: Karreth Johannes , Sullivan Patricia Lynne , Dezfuli Ghazal 
Published: January 2020

AbstractSocieties emerging from internal armed conflicts display surprising variation in the degree to which governments protect human rights. Employing new data on civilian victimization by both government and rebel forces, we find that the human rights climate of a post-conflict country is not simply a perpetuation of pre-conflict conditions, or the result of repressive regimes remaining in power. Instead, the treatment of civilians during conflict has an independent impact on post-conflict human rights protections (HRP). Analyses of ninety-six post-conflict periods (1960–2015) show that when governments systematically and extensively target civilians during counterinsurgency campaigns, post-conflict human rights conditions decline substantially compared to pre-conflict levels, even accounting for other predictors of human rights violations, including pre-conflict human rights conditions. This holds regardless of who is in power after conflicts end. These findings have implications for theoretical models of repression and conflict cycles, and for practitioners and policymakers aiming to restore and protect human rights after war.
Investigation of 4D dose in volumetric modulated arc therapy-based stereotactic body radiation therapy: does fractional dose or number of arcs matter?
Authors: Shintani Takashi , Nakamura Mitsuhiro , Matsuo Yukinori , Miyabe Yuki , Mukumoto Nobutaka , Mitsuyoshi Takamasa , Iizuka Yusuke , Mizowaki Takashi 
Published: January 2020

Abstract
The aim of this study was to assess the impact of fractional dose and the number of arcs on interplay effects when volumetric modulated arc therapy (VMAT) is used to treat lung tumors with large respiratory motions. A three (fractional dose of 4, 7.5 or 12.5 Gy) by two (number of arcs, one or two) VMAT plan was created for 10 lung cancer cases. The median 3D tumor motion was 17.9 mm (range: 8.2–27.2 mm). Ten phase-specific subplans were generated by calculating the dose on each respiratory phase computed tomography (CT) scan using temporally assigned VMAT arcs. We performed temporal assignment of VMAT arcs using respiratory information obtained from infrared markers placed on the abdomens of the patients during CT simulations. Each phase-specific dose distribution was deformed onto exhale phase CT scans using contour-based deformable image registration, and a 4D plan was created by dose accumulation. The gross tumor volume dose of each 4D plan (4D GTV dose) was compared with the internal target volume dose of the original plan (3D ITV dose). The near-minimum 4D GTV dose (D99%) was higher than the near-minimum 3D internal target volume (ITV) dose, whereas the near-maximum 4D GTV dose (D1%) was lower than the near-maximum 3D ITV dose. However, the difference was negligible, and thus the 4D GTV dose corresponded well with the 3D ITV dose, regardless of the fractional dose and number of arcs. Therefore, interplay effects were negligible in VMAT-based stereotactic body radiation therapy for lung tumors with large respiratory motions.
Treatment outcomes of patients with adenocarcinoma of the uterine cervix after definitive radiotherapy and the prognostic impact of tumor-infiltrating CD8+ lymphocytes in pre-treatment biopsy specimens: a multi-institutional retrospective study
Authors: Miyasaka Yuhei , Yoshimoto Yuya , Murata Kazutoshi , Noda Shin-ei , Ando Ken , Ebara Takeshi , Okonogi Noriyuki , Kaminuma Takuya , Yamada Seiji , Ikota Hayato , Yokoo Hideaki , Ohno Tatsuya , Nakano Takashi 
Published: January 2020

Abstract
The current study aimed to evaluate the outcomes of patients with adenocarcinoma (AC) of the uterine cervix after definitive radiotherapy (RT) and to evaluate prognostic factors, including immunity-related molecules. A total of 71 patients with AC of the uterine cervix from multiple Japanese institutions were retrospectively analysed. Histological subtypes were diagnosed according to the 2014 World Health Organization classification. All patients underwent definitive RT comprising external beam RT and intracavitary brachytherapy with or without concurrent chemotherapy. Immunohistochemical studies were performed to detect the expression of programmed cell death-ligand 1(PD-L1) and CD8. The 5-year locoregional control (LC), overall survival (OS) and progression-free survival (PFS) rates for all patients were 61.8, 49.7 and 36.1%, respectively. The LC, OS and PFS rates were not significantly different among the histological subtypes. Membranous PD-L1 expression was not significantly associated with prognosis. Patients with CD8-positive tumor-infiltrating lymphocytes (CD8+TILs) in the tumor nests had significantly better OS than patients without CD8+TILs in the tumor nests (5-year OS: 53.8 vs 23.8%, P = 0.038). As expected, the International Federation of Gynecology and Obstetrics (FIGO) stage (2008) III–IVA and maximum tumor diameter &gt; 40 mm were significantly associated with worse prognosis. In summary, the presence of CD8+TILs in the tumor nests has the potential to be an independent favorable prognostic factor for patients with AC of the uterine cervix after definitive RT.
Mucinous appendiceal adenocarcinomas: a diagnostic challenge
Authors: Sharma Ekta , Gokani Shyam Ajay , Neville Jonathan , Sinha Ashish , Agarwal Tushar 
Published: January 2020

Abstract
Mucinous appendiceal neoplasms are rare and diagnosis is often difficult as patients present with non-specific symptoms often suggestive of appendicitis only and most diagnoses are made following post-surgery histology examination. Here we present a case of a mucinous appendiceal adenocarcinoma with areas of both Low-grade Appendiceal Mucinous Neoplasm and High-grade Appendiceal Mucinous Neoplasm, in a ruptured appendix at a district general hospital. Without early detection and treatment these pathologies can lead to pseudomyxoma peritonei, a syndrome of progressive mucinous ascites. This case highlights the limitations of radiological studies, benefits of diagnostic laparoscopy and provides a rationale for removing the mesoappendix with the appendix during routine appendectomies.
14-3-3η Protein in Rheumatoid Arthritis: Promising Diagnostic Marker and Independent Risk Factor for Osteoporosis
Authors: Zeng Tingting , Tan Liming , Wu Yang , Yu Jianlin 
Published: January 2020

Abstract

Background
Early identification and disease monitoring are challenges facing rheumatologists in the management of rheumatoid arthritis (RA).

Methods
We utilized enzyme-linked immunosorbent assay (ELISA) to determine 14-3-3η and anticyclic citrullinated peptide antibody (anti-CCP) levels, with rheumatoid factor (RF) level detected by rate nephelometry. The diagnostic value of each index was determined via receiver operating characteristic (ROC) curve, and the association between 14-3-3η and osteoporosis was assessed using multiple logistic regression analysis.

Results
Serum levels of 14-3-3η were 3.26 ng per mL in patients with RA. These levels were helpful in identifying patients with the disease, with the area under the curve (AUC) being 0.879 and 0.853, respectively, from all healthy control individuals and patients with RA. Combining 14-3-3η with RF or anti-CCP increased the diagnostic rate. Logistic regression analysis identified 14-3-3η as an independent risk factor for RA-related osteoporosis (odds ratio [OR], 1.503; 95% confidence interval [CI], 1.116–2.025; P &lt;.01).

Conclusions
Serum 14-3-3η detection by itself or combined with other serum indices was helpful in differentiating patients with RA. Also, it was a promising biomarker for disease monitoring in RA.
Augmented Reality–Assisted Dementia Care
Authors: Zhao Mengyu Y. , Ong S. K. , Nee Andrew Y. C. 
Published: January 2020

Abstract
With the increasing aging population, the number of people suffering from dementia continues to grow at a high rate. Emerging technologies have been applied to support the independence of patients with dementia. Among these technologies, augmented reality (AR) technology augments computer-generated virtual content on the real-world environment. There is an increasing interest in the use of AR tools and applications for dementia care as these tools and applications are capable of providing intuitive interaction and reducing the workload of caregivers. This chapter presents a state-of-the-art overview of AR-assisted applications for dementia care. An AR-assisted healthcare exercising system that enhances the user’s motor skills and cognition capability is presented to illustrate the use of AR in dementia care. Furthermore, an outlook of the future of AR-assisted dementia care applications is presented.
Caring for Older Adults with Dementia
Authors: Wangmo Tenzin 
Published: January 2020

Abstract
In light of increasing life expectancy and population aging, healthcare systems today face the challenge of addressing the care-related needs of an increasingly aging population. Aging compounded with physical and neurological deteriorations means greater caregiving demands for both the formal healthcare sector and informal care from family members and friends. Unpaid informal caregiving is cost effective for the healthcare system as a whole; however, providing care for a family member with dementia can negatively impact the health of the caregiver. The increasing development and deployment of assistive technology is predicted to alleviate caregiving burden and allow the older person with dementia to remain independent and continue to live at home for as long as possible. This chapter presents the landscape of information on informal caregiving for patients with dementia and its associated caregiving burden. It also discusses the evidence available on the potential of assistive technology for alleviating informal caregiving burden. The chapter concludes with some considerations about the governance of assistive technology. It argues that assistive technologies that are proven to be clinically effective should be made fairly and ubiquitously available to improve the quality of life of the person with dementia and his or her family caregiver. This is important to ensure the sustainability of the overall healthcare system.
Signatures of bimodality in nebular phase Type Ia supernova spectra
Authors: Vallely P J , Tucker M A , Shappee B J , Brown J S , Stanek K Z , Kochanek C S 
Published: January 2020

ABSTRACT
One observational prediction for Type Ia supernovae (SNe Ia) explosions produced through white dwarf–white dwarf collisions is the presence of bimodal velocity distributions for the 56Ni decay products, although this signature can also be produced by an off-centre ignition in a delayed detonation explosion. These bimodal velocity distributions can manifest as double-peaked or flat-topped spectral features in late-time spectroscopic observations for favourable viewing angles. We present nebular-phase spectroscopic observations of 17 SNe Ia obtained with the Large Binocular Telescope. Combining these observations with an extensive search of publicly available archival data, we collect a total sample of 48 SNe Ia and classify them based on whether they show compelling evidence for bimodal velocity profiles in three features associated with 56Ni decay products: the [Fe ii] and [Fe iii] feature at ∼5300 Å, the [Co iii] λ5891 feature, and the [Co iii] and [Fe ii] feature at ∼6600 Å. We identify nine bimodal SNe in our sample, and we find that these SNe have average peak MV about 0.3 mag fainter than those that do not. This is consistent with theoretical predictions for explosions created by nearly head-on collisions of white dwarfs due to viewing angle effects and 56Ni yields.
Galaxies hosting an active galactic nucleus: a view from the CALIFA survey
Authors: Lacerda Eduardo A D , Sánchez Sebastián F , Cid Fernandes R , López-Cobá Carlos , Espinosa-Ponce Carlos , Galbany L 
Published: January 2020

ABSTRACT
We study the presence of optically-selected active galactic nuclei (AGNs) within a sample of 867 galaxies extracted from the extended Calar-Alto Legacy Integral Field spectroscopy Area (eCALIFA) spanning all morphological classes. We identify 10 Type-I and 24 Type-II AGNs, amounting to ∼4 per cent of our sample, similar to the fraction reported by previous explorations in the same redshift range. We compare the integrated properties of the ionized and molecular gas, and stellar population of AGN hosts and their non-active counterparts, combining them with morphological information. The AGN hosts are found in transitory parts (i.e. green-valley) in almost all analysed properties which present bimodal distributions (i.e. a region where reside star-forming galaxies and another with quiescent/retired ones). Regarding morphology, we find AGN hosts among the most massive galaxies, with enhanced central stellar-mass surface density in comparison to the average population at each morphological type. Moreover, their distribution peaks at the Sab-Sb classes and none are found among very late-type galaxies (&gt;Scd). Finally, we inspect how the AGN could act in their hosts regarding the quenching of star-formation. The main role of the AGN in the quenching process appears to be the removal (or heating) of molecular gas, rather than an additional suppression of the already observed decrease of the star-formation efficiency from late-to-early type galaxies.
A study of the high-inclination population in the Kuiper belt – III. The 4:7 mean-motion resonance
Authors: Li Jian , Lawler S M , Zhou Li-Yong , Sun Yi-Sui 
Published: January 2020

ABSTRACT
The high-inclination population in the 4:7 mean-motion resonance (MMR) with Neptune has also substantial eccentricities (e ≳ 0.1), with more inclined objects tending to occupy more eccentric orbits. For this high-order resonance, there are two different resonant modes. The principal one is the eccentricity-type mode, and we find that libration is permissible for orbits with $e\ge e_\mathrm{ c}^0$, where the critical eccentricity $e_\mathrm{ c}^0$ increases as a function of increasing inclination i. Correspondingly, we introduce a limiting curve $e_\mathrm{ c}^0(i)$, which puts constraints on the (e, i) distribution of possible 4:7 resonators. We then perform numerical simulations on the sweep-up capture and long-term stability of the 4:7 MMR, and the results show that the simulated resonators are well constrained by this theoretical limiting curve. The other 4:7 resonant mode is the mixed-(e, i)-type, and we show that stable resonators should exist at i ≳ 20○. We predict that the intrinsic number of these mixed-(e, i)-type resonators may provide a new clue into the Solar system’s evolution, but, so far, only one real object has been observed resonating in this mode.
Embedding globular clusters in dark matter minihaloes solves the cusp–core and timing problems in the Fornax dwarf galaxy
Authors: Boldrini Pierre , Mohayaee Roya , Silk Joseph 
Published: January 2020

ABSTRACT
We use a fully GPU N-body code to demonstrate that dark matter (DM) minihaloes, as a new component of globular clusters (GCs), resolve both the timing and cusp–core problems in Fornax if the (five or six) GCs were recently accreted (≤3 Gyr ago) by Fornax. Under these assumptions, infall of these GCs does not occur and no star clusters form in the centre of Fornax in accordance with observations. We find that crossings of GCss that have DM minihaloes near the Fornax centre induce a cusp-to-core transition of the DM halo and hence resolve the cusp–core problem in this dwarf galaxy. The DM core size depends on the frequency of GC crossings. Our simulations clearly demonstrate also that between the passages, the DM halo can regenerate its cusp. Moreover, our models are in good agreement with constraints on the DM masses of GCs as our clusters lose a large fraction of their initial DM minihaloes. These results provide circumstantial evidence for the universal existence of DM haloes in GCs.
Investigation of chemical differentiation among the NGC 2264 cluster-forming clumps
Authors: Taniguchi Kotomi , Plunkett Adele , Herbst Eric , Dobashi Kazuhito , Shimoikura Tomomi , Nakamura Fumitaka , Saito Masao 
Published: January 2020

ABSTRACT
We have carried out mapping observations of molecular emission lines of HC3N and CH3OH toward two massive cluster-forming clumps, NGC 2264-C and NGC 2264-D, using the Nobeyama 45-m radio telescope. We derive an I(HC3N)/I(CH3OH) integrated intensity ratio map, showing a higher value at clumps including 2MASS (Two Micron All Sky Survey) point sources at the northern part of NGC 2264-D. Possible interpretations of the I(HC3N)/I(CH3OH) ratio are discussed. We have also observed molecular emission lines from CCS and N2H+ toward five positions in each clump. We investigate the N(N2H+)/N(CCS) and N(N2H+)/N(HC3N) column density ratios among the ten positions in order to test whether they can be used as chemical evolutionary indicators in these clumps. The N(N2H+)/N(CCS) ratio shows a very high value toward a bright embedded IR source (IRS1), whereas the N(N2H+)/N(HC3N) ratio at IRS1 is comparable with those at the other positions. These results suggest that ultraviolet radiation affects the chemistry around IRS1. We find that there are positive correlations between these column density ratios and the excitation temperatures of N2H+, which implies the chemical evolution of clumps. These chemical evolutionary indicators likely reflect the combination of evolution along the filamentary structure and evolution of each clump.
Winds and feedback from supermassive black holes accreting at low rates: hydrodynamical treatment
Authors: Almeida Ivan , Nemmen Rodrigo 
Published: January 2020

ABSTRACT
Outflows produced by a supermassive black hole (SMBH) can have important feedback effects in its host galaxy. An unresolved question is the nature and properties of winds from SMBHs accreting at low rates in low-luminosity active galactic nuclei (LLAGNs). We performed two-dimensional numerical, hydrodynamical simulations of radiatively inefficient accretion flows on to non-spinning black holes. We explored a diversity of initial conditions in terms of rotation curves and viscous shear stress prescriptions, and evolved our models for very long durations of up to 8 × 105GM/c3. Our models resulted in powerful subrelativistic, thermally driven winds originated from the corona of the accretion flow at distances 10−100 GM/c2 from the SMBH. The winds reached velocities of up to 0.01c with kinetic powers corresponding to $0.1\!-\!1 {\,{\rm per\, cent}}$ of the rest-mass energy associated with inflowing gas at large distances, in good agreement with models of the ‘radio mode’ of AGN feedback. The properties of our simulated outflows are in broad agreement with observations of winds in quiescent galaxies that host LLAGNs, which are capable of heating ambient gas and suppressing star formation.
The properties of prompt emission in short gamma-ray bursts with extended emission observed by Fermi/GBM
Authors: Lan Lin , Lu Rui-Jingi , Lü Hou-Jun , Shen Jun , Rice Jared , Li Long , Liang En-Wei 
Published: January 2020

ABSTRACT
Short gamma-ray bursts (GRB) with extended emission (EE) that are composed of an initial short hard spike followed by a long-lasting EE are thought to comprise a sucategory of short GRBs. The narrow energy band available during the Swift era, combined with a lack of spectral information, prevented the discovery of the intrinsic properties of these events. In this paper, we perform a systematic search of short GRBs with EE using all available Fermi/GBM data. The search identified 26 GBM-detected short GRBs with EE that are similar to GRB 060614 observed by Swift/BAT. We focus on investigating the spectral and temporal properties of both the hard spike and the EE component of all 26 GRBs, and explore differences and possible correlations between them. We find that while the peak energy (Ep) of the hard spikes is slightly harder than that of the EE, their fluences are comparable. The harder Ep seems to correspond to a larger fluence and peak flux, with a large scatter for both the hard spike and the EE component. Moreover, the Ep of both the hard spike and the EE are compared with other short GRBs. Finally, we also compare the properties of GRB 170817A with those of short GRBs with EE and find no significant statistical differences between them. We find that GRB 170817A has the lowest Ep, probably because it is off-axis.
Evidence for Galactic disc RR Lyrae stars in the solar neighbourhood
Authors: Prudil Z , Dékány I , Grebel E K , Kunder A 
Published: January 2020

ABSTRACT
We present a kinematical study of 314 RR Lyrae stars in the solar neighbourhood using the publicly available photometric, spectroscopic, and Gaia DR2 astrometric data to explore their distribution in the Milky Way. We report an overdensity of 22 RR Lyrae stars in the solar neighbourhood at a pericentre distance of between 5 and 9 kpc from the Galactic Centre. Their orbital parameters and their chemistry indicate that these 22 variables share the kinematics and the [Fe/H] values of the Galactic disc, with an average metallicity and tangential velocity of [Fe/H] = −0.60 dex and vθ = 241 km s−1, respectively. From the distribution of the Galactocentric spherical velocity components, we find that these 22 disc-like RR Lyrae variables are not consistent with the Gaia Sausage (Gaia-Enceladus), unlike almost half of the local RR Lyrae stars. Chemical information from the literature shows that the majority of the selected pericentre-peak RR Lyrae variables are α-poor, a property shared by typically much younger stars in the thin disc. Using the available photometry, we rule out a possible misclassification with the known classical and anomalous Cepheids. The similar kinematic, chemical, and pulsation properties of these disc RR Lyrae stars suggest they share a common origin. In contrast, we find that the RR Lyrae stars associated with the Gaia-Enceladus based on their kinematics and chemical composition show a considerable metallicity spread in the old population (∼1 dex).