bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rates of re-excision and conversion to mastectomy after breast-conserving surgery with or without oncoplastic surgery: a nationwide population-based study
Authors: Heeg E , Jensen M B , Hölmich L R , Bodilsen A , Tollenaar R A E M , Lænkholm A V , Offersen B V , Ejlertsen B , Mureau M A M , Christiansen P M 
Published: August 2020

Abstract

Background
There is no consensus regarding the impact of oncoplastic surgery (OPS) on rates of re-excision and conversion to mastectomy following breast-conserving surgery (BCS). Here these two outcomes after BCS and OPS were compared in a nationwide population-based setting.

Methods
In Denmark, all OPS is registered and categorized into volume displacement, volume reduction or volume replacement. Patients who underwent BCS or OPS between 2012 and 2018 were selected from the Danish Breast Cancer Group database. Multivariable analyses were performed to adjust for confounders, and propensity score matching to limit potential confounding by indication bias.

Results
A total of 13 185 patients (72·5 per cent) underwent BCS and 5003 (27·5 per cent) OPS. Volume displacement was used in 4171 patients (83·4 per cent), volume reduction in 679 (13·6 per cent) and volume replacement in 153 (3·1 per cent). Re-excision rates were 15·6 and 14·1 per cent after BCS and OPS respectively. After adjusting for confounders, patients were less likely to have a re-excision following OPS than BCS (odds ratio (OR) 0·80, 95 per cent c.i. 0·72 to 0·88), specifically after volume displacement and reduction. The rate of conversion to mastectomy was similar after OPS and BCS (3·2 versus 3·7 per cent; P = 0·105), but with a lower risk in adjusted analysis (OR 0·69, 0·58 to 0·84), specifically after volume displacement and reduction procedures. Findings were similar after propensity score matching.

Conclusion
A modest decrease in re-excision rate and less frequent conversion to mastectomy were observed after OPS compared with BCS.
Lymphocytic interstitial pneumonia with tiny cysts of peribronchovascular distribution on CT
Authors: Hanafiah Mohammad , Johari Bushra , Abdul Kadir Roqiah Fatmawati , Bakar Nor Salmah , Baharuddin Hazlyna 
Published: August 2020

AbstractCysts are a common finding of lymphocytic interstitial pneumonia (LIP) on imaging. Usually, they are limited in number and size. Tiny and numerous cysts of peribronchovascular distribution are less typical but a recognized appearance in LIP.
A duplex qPCR assay for human erythropoietin (EPO) transgene to control gene doping in horses
Authors: Cheung Hiu Wing , Wong Kin‐Sing , Lin Venus Y.C. , Wan Terence S.M. , Ho Emmie N.M. 
Published: August 2020

AbstractThe misuse of genetic manipulation technology to enhance athletic performance is termed gene doping which is prohibited in human sports, horseracing, and equestrian sports. Although many qPCR assays have been developed, most assays employ genomic DNA (gDNA) from humans, non‐human primates, and mice as a background and they may not be applicable for testing horse samples. This study aimed to develop a qPCR assay for the detection of human erythropoietin (hEPO) transgene in horse blood cells where the viral vectors used in gene therapy can reside for months. For the detection of hEPO transgene, the performance of three sets of primers and a hydrolysis probe for hEPO were compared. One set showed adequate specificity, sensitivity, amplification efficiency, and a dynamic range of detection in the presence of horse gDNA. The assay was duplexed with the detection of horse tubulin α 4A (TUBA4A) gene as an endogenous internal control in order to prevent false‐negative results due to poor recovery and storage of extracted DNA and/or qPCR experimental variation. For the extraction of hEPO‐plasmid, the QIAGEN Gentra Puregene blood kit was shown to recover the majority (62%) of hEPO‐plasmid from spiked horse blood cells. The specificity and limit of detection (LOD) of the duplex qPCR assay were determined in accordance with MIQE guidelines. These findings supported the application of this duplex qPCR assay to the detection of hEPO transgene in horse blood cells.
The brief (seven‐item) eating disorder examination‐questionnaire: Evaluation of a non‐nested version in men and women
Authors: Jenkins Paul E. , Davey Emily 
Published: August 2020

AbstractObjectiveSeveral recent studies have examined the psychometric properties of brief measures of eating disorder attitudes based on the Eating Disorder Examination Questionnaire (EDE‐Q). A seven‐item version (the EDE‐Q7) has been proposed but, as yet, has only been investigated by looking at the items when presented as part of the longer EDE‐Q (i.e., as a nested version). The current study presented the EDE‐Q7 as a standalone instrument and examined factor structure fit and measurement invariance across male and female genders.MethodsUniversity students (244 women; 155 men; 1 did not identify with either gender) completed questionnaires as part of two independent studies. All individuals completed the EDE‐Q7 and measures of eating disorder behaviors. In a mixed‐gender subsample (n = 286), measures of depression and eating disorder‐specific quality of life were also included. Confirmatory factor analysis of the EDE‐Q7 was conducted on males and females independently, in addition to estimates of internal consistency reliability and validity. Measurement invariance was assessed through multigroup confirmatory factor analysis.ResultsThe EDE‐Q7 demonstrated good internal consistency and findings supported measurement invariance by gender. In a mixed‐gender subsample, the measure showed positive associations with depression and both eating disorder behaviors and eating disorder‐specific quality of life.DiscussionThe present study adds to the literature supporting the psychometric properties of the EDE‐Q7, extending this to use of the questionnaire as a standalone instrument. Measurement invariance suggests that the measure may be appropriate for college‐age men and women, although future studies should establish psychometric properties more fully.
Pericardial waffle for effusive‐constrictive pericarditis
Authors: Kiamanesh Omid , Luk Adriana , Nesbitt Gillian C. , Badiwala Mitesh , Mak Susanna 
Published: August 2020

AbstractWe present the case of a 55‐year‐old female marathon runner who presented with progressive exercise intolerance and was diagnosed with effusive‐constrictive pericarditis. Stereotypical findings of this challenging diagnosis are shown by transthoracic echocardiographic and right heart catheterization. We treated the patient with a parietal pericardiectomy and pericardial waffle procedure to relieve a thick and constrictive epicardium.
Circulating memory CD8+ T cells are limited in forming CD103+ tissue‐resident memory T cells at mucosal sites after reinfection
Authors: Behr Felix M. , Beumer‐Chuwonpad Ammarina , Kragten Natasja A. M. , Wesselink Thomas H. , Stark Regina , van Gisbergen Klaas P. J. M. 
Published: August 2020

AbstractTissue‐resident memory CD8+ T cells (TRM) localize to barrier tissues and mediate local protection against reinvading pathogens. Circulating central memory (TCM) and effector memory CD8+ T cells (TEM) also contribute to tissue recall responses, but their potential to form mucosal TRM remains unclear. Here, we employed adoptive transfer and lymphocytic choriomeningitis virus reinfection models to specifically assess secondary responses of TCM and TEM at mucosal sites. Donor TCM and TEM exhibited robust systemic recall responses, but only limited accumulation in the small intestine, consistent with reduced expression of tissue‐homing and ‐retention molecules. Murine and human circulating memory T cells also exhibited limited CD103 upregulation following TGF‐β stimulation. Upon pathogen clearance, TCM and TEM readily gave rise to secondary TEM. TCM also formed secondary central memory in lymphoid tissues and TRM in internal tissues, for example, the liver. Both TCM and TEM failed to substantially contribute to resident mucosal memory in the small intestine, while activated intestinal TRM, but not liver TRM, efficiently reformed CD103+ TRM. Our findings demonstrate that circulating TCM and TEM are limited in generating mucosal TRM upon reinfection. This may pose important implications on cell therapy and vaccination strategies employing memory CD8+ T cells for protection at mucosal sites.
Aspects of the volunteering experience associated with well‐being in older adults
Authors: Jongenelis Michelle I. , Pettigrew Simone 
Published: August 2020

AbstractIssues addressedWhile the psychological health benefits of older people's engagement in formal volunteering are well‐documented, there is limited research assessing how volunteering may produce these favourable outcomes. To guide the development of volunteer positions that optimise outcomes, this study examined (a) which aspects of the volunteering experience are most strongly associated with favourable psychological health among older adults and (b) whether relationships between these aspects and psychological outcomes are moderated by sociodemographic characteristics.MethodsA sample of 293 volunteers aged 60+ years (69% female, mean age = 73.33 years) completed measures assessing their engagement in volunteering, various aspects of their volunteer experience, and their psychological health.ResultsBeing adequately appreciated for one's contribution, perceived social and mental intensity of the volunteer role, and believing that others benefit from one's volunteering efforts were found to be associated with higher levels of psychological health.ConclusionsEnsuring the contributions of volunteers are explicitly recognised, providing opportunities for engagement in social and cognitive activities, and informing volunteers of the benefits others experience constitute potential means of enhancing volunteer outcomes and may assist with volunteer retention.So what?This study builds upon the limited research assessing which aspects of the volunteering experience are most strongly associated with favourable psychological health among older adults. The findings point to the potential importance of four specific aspects of the volunteer experience in enhancing psychological health outcomes.
Gender‐dependent association between exhaled nitric oxide and the CC16 38AA genotype in young school children
Authors: Nauwelaerts Sarah J. D. , Roosens Nancy H. C. , De Cremer Koen , Bernard Alfred , De Keersmaecker Sigrid C. J. 
Published: August 2020

AbstractBackgroundStudies that investigated the association between the CC16 A38G polymorphism and the risk of asthma yielded conflicting results. The aim of this study among schoolchildren was to assess the relationships of CC16 A38G polymorphism with aeroallergen sensitization and fractional exhaled nitric oxide (FeNO), two outcomes predicting asthma later in life.MethodsThe study included 139 children (72 boys), median age of 7.7. Information on each child's health, lifestyle, and environment was collected through a questionnaire completed by their parents. CC16 genotypes were determined using urinary DNA. We measured FeNO, the CC16 protein in urine and nasal lavage fluid and aeroallergen‐specific immunoglobulin E in nasal mucosa fluid.ResultsChildren with the homozygous mutant CC16 38AA genotype had higher odds of increased FeNO (>30 ppb) compared with their peers with the wild‐type genotype 38GG (OR, 9.85; 95% CI, 2.09‐46.4; P = .004). This association was female gender specific (P = .002) not being observed in boys (P = .40). It was also independent of allergic sensitization, which yet emerged as the strongest predictor of FeNO along with the use of bleach for house cleaning. Children with the CC16 38AA genotype had lower covariates‐adjusted urinary CC16 levels than those with 38GG (median, μg/L, 1.17 vs 2.08, P = .02).ConclusionOur study suggests that the CC16 38AA allele promotes airway inflammation as measured by FeNO through a gender‐dependent association. Deficient levels of CC16 in the deep lung, measured noninvasively in urine, as a possible proxy for serum CC16, might underlie this promoting effect.
A SOM‐based analysis of the drivers of the 2015–2017 Western Cape drought in South Africa
Authors: Odoulami Romaric C. , Wolski Piotr , New Mark 
Published: August 2020

AbstractThe multi‐year (2015–2017) drought in the South West of the Western Cape (SWC) caused a severe water shortage in the summer of 2017–2018, with damaging impacts on the local and regional economy, and Cape Town being in the news one of the first major cities to potentially run out of water. Here, we assess the links between the rainfall deficits during the drought and (a) large scale circulation patterns, (b) moisture transport, and (c) convective available potential energy (CAPE). We used self‐organising maps (SOM) analysis to classify daily ERA‐interim 850 hPa geopotential height for the period 1979–2017 (March–October) into synoptic types. This allowed us to identify the dominant synoptic states over Southern Africa that influence the local climate in the area affected by the drought. The results show that (a) the frequency of nodes with rain‐bearing circulation types decreased during the drought; (b) the amount of rain falling on days that did have rain‐bearing circulation types was reduced, especially in the shoulder seasons (March–May and August–October); (c) the rainfall reduction was also associated with anomalously low moisture transport, and convective energy (CAPE), over SWC. These results add to the existing knowledge of drivers of the Cape Town drought, providing an understanding of underlying synoptic processes.
Parenteral Provision of Micronutrients to Pediatric Patients: An International Expert Consensus Paper
Authors: Hardy Gil , Wong Theodoric , Morrissey Hana , Anderson Collin , Moltu Sissel J. , Poindexter Brenda , Lapillonne Alexandre , Ball Patrick A. 
Published: August 2020

AbstractIntroductionMicronutrients (vitamins and trace elements) are essential to all nutrition. For children and neonates who are dependent upon nutrition support therapies for growth and development, the prescribed regimen must supply all essential components. This paper aims to facilitate interpretation of existing clinical guidelines into practical approaches for the provision of micronutrients in pediatric parenteral nutrition.MethodsAn international, interdisciplinary expert panel was convened to review recent evidence‐based guidelines and published literature to develop consensus‐based recommendations on practical micronutrient provision in pediatric parenteral nutrition.ResultsThe guidelines and evidence have been interpreted as answers to 10 commonly asked questions around the practical principles for provision and monitoring of micronutrients in pediatric patients.ConclusionMicronutrients are an essential part of all parenteral nutrition and should be included in the pediatric nutrition therapy care plan.
Relationships between the motivation of medical tourists and the quality of medical services
Authors: Lee Timothy J. , Lim Hyunsuk , Kim Dohee 
Published: August 2020

AbstractThis study aims to: (a) identify the motivation to travel for medical reasons and the quality of the medical services received; and (b) examine the relationship between the quality of medical services and the attitudes held by tourists about these. It fills the gap in the literature by contributing to our knowledge of medical tourists' behavior. A total of 500 questionnaires were distributed at 25 hospitals and travel agencies within Korea. The results deliver insightful messages in the fields of travel behavior and motivation in the medical tourism industry, and for health marketers and planners of medical tourism services.
The anti‐infection drug furazolidone inhibits NF‐κB signaling and induces cell apoptosis in small cell lung cancer
Authors: Yu Jin‐Guo , Ji Cheng‐Hong , Shi Min‐Hua 
Published: August 2020

AbstractTargeting nuclear factor kappa B (NF‐κB) signaling pathway has become a promising strategy for the development of new antitumor drugs. In this paper, we found that anti‐infection drug furazolidone (FZD) could significantly inhibit NF‐κB‐driven luciferase activity, and FZD could markedly inhibit both of the constitutive and tumor necrosis factor‐α (TNFα)‐triggered phosphorylation of NF‐κB p65 in small cell lung cancer (SCLC). Further studies revealed that FZD inhibited the expression of inhibitor of kappa B kinase β (IKKβ) in SCLC cells. In addition, we found that FZD had significant antitumor activities in SCLC cells. FZD could markedly suppress the cell viability of SCLC cells dose‐dependently, and FZD could significantly induce the cleavages of poly ADP‐ribose polymerase (PARP) and Caspase3, the biomarkers of cell apoptosis, in SCLC cells. The flow cytometry also revealed that FZD induced cell apoptosis in SCLC cells. Finally, we also found that overexpression of constitutively activated IKKβ could significantly abolish FZD‐induced cell growth inhibition in SCLC cells, which further confirmed that FZD displayed its anti‐SCLC activity through regulating NF‐κB signaling pathway.
Network Mesh Nanostructures in Cross‐Linked Poly(Dimethylsiloxane) Visualized by AFM
Authors: Drebezghova Viktoriia , Gojzewski Hubert , Allal Ahmed , Hempenius Mark A. , Nardin Corinne , Vancso G. Julius 
Published: August 2020

AbstractMesh network structures are visualized by peak force tapping atomic force microscopy on cross‐linked poly(dimethylsiloxane) (PDMS) at the nanometer length scale. The images directly capture network mesh structures with mesh diameter values, from 10 to 16 nm at the free surface of PDMS. Perpendicular to the free surface, in cross‐sectional areas exposed by cryo‐fracturing, similar mesh structures are observed. When exposed to uniaxial stress, the circular mesh features become elongated, showing network deformation at the nanoscale, as a result of mechanical stress. Following Soxhlet solvent extraction the mesh‐like appearance remains unchanged, but mesh diameter values decrease, which are attributed to the removal of non‐crosslinked chains and silica filler.
Ultra‐wideband multi‐section Wilkinson power divider
Authors: Shaterian Zahra , Karami Horestani Ali 
Published: August 2020

AbstractA multi‐section ultra‐wideband Wilkinson power divider is presented in this article. The proposed device is developed based on a coplanar waveguide (CPW) to coplanar strip (CPS) transition, which is realized on a two‐layer printed circuit board without using via holes. Equivalent circuit model of the proposed power divider is presented, and on that basis a three‐section power divider with an ultra‐wideband performance, ranging from 3 to 16 GHz is designed and numerically validated. Finally, prototypes of the proposed device is fabricated and measured to provide an experimental verification on the numerically predicted features, namely the operating bandwidth, input/output impedance matching, insertion loss, isolation between output ports, and amplitude/phase balance at output ports.
A contact problem for a poroelastic halfspace containing an embedded inextensible membrane
Authors: Samea P. , Selvadurai A.P.S. 
Published: August 2020

SummaryThe paper examines the axisymmetric problem of the indentation of a poroelastic halfspace that is reinforced with an inextensible permeable/impermeable membrane located at a finite depth by a rigid indenter. The constitutive behavior of the poroelastic halfspace is described by the three‐dimensional theory of poroelasticity proposed by M.A. Biot. The contact conditions between the indenter and the poroelastic halfspace are varied to accommodate both adhesive/frictionless contact and impermeable/permeable conditions. The formulation of the mixed boundary value problems uses the stress function approaches applicable to semi‐infinite domains. Successive applications of Laplace and Hankel integral transforms are used to reduce the mixed boundary value problems to sets of coupled Fredholm integral equations of the second kind. These integral equations are solved using numerical approaches, applicable both for the solution of the systems of coupled equations and for Laplace transform inversion, to examine the time‐dependent displacement of the rigid indenter. The analytical‐numerical estimates for the time‐dependent displacements of the rigid indenter are compared with results obtained using a finite element approach.
Further results on the Drazin inverse of even‐order tensors
Authors: Behera Ratikanta , Nandi Ashish Kumar , Sahoo Jajati Keshari 
Published: August 2020

SummaryThe notion of the Drazin inverse of an even‐order tensors with the Einstein product was introduced, very recently [J. Ji and Y. Wei. Comput. Math. Appl., 75(9), (2018), pp. 3402‐3413]. In this article, we further elaborate this theory by establishing a few characterizations of the Drazin inverse and ‐weighted Drazin inverse of tensors. In addition to these, we compute the Drazin inverse of tensors using different types of generalized inverses and full rank decomposition of tensors. We also address the solution of multilinear systems by using the Drazin inverse and iterative (higher order Gauss‐Seidel) method of tensors. Besides these, the convergence analysis of the iterative technique is also investigated within the framework of the Einstein product.
Thermal aging, physico‐mechanical, dynamic mechanical properties of chlorinated polyethylene/red mud composites
Authors: Qiu Liyan , Phule Ajit D. , Han Yingxia , Wen Shibao , Zhang Zhen‐Xiu 
Published: August 2020

AbstractIndustrial waste red mud (RM) was filled in the chlorinated polyethylene rubber (CPE) to replace carbon black (CB) at various ratios, that is, RM/CB (40/20, 20/40, 10/50, 5/55, 0/60) in the production of CPE/RM composite materials. The mechanical and thermal properties of CPE/RM with varied proportion of RM and CB were studied. The tensile strength of the CPE/RM/CB composite were improved compare to without RM (ie, improved from 10 to 14 MPa) and thermal degradation temperature (Td2) has improved from 435°C to 445°C, when the content of red mud was 20 phr. After aging for 3 days, the hardness and tensile strength of CPE/RM/CB composites were improved, that is, increment in hardness by 10 shore A and tensile strength by 2 MPa. CPE shows good thermal stability (with Td2 = 445°C) with the increment of RM and CB proportion, noticeably, when the ratio of red mud/carbon black is 20/40. The analysis by RPA (Rubber Process Analyzer) showed Payne effect became apparent when the amount of red mud was more than 20 phr. The compound with 60 phr CB load showed the largest elastic modulus G′ which decreased fastest at strain 0.28%, almost as the same as 40/20 CB/RM, but the elastic modulus G′ of 40/20 CB/RM showed a slight decrease when the strain exceeded 65%. The overall properties of the composite filled with 20 phr red mud were better in comparison with other varied ratios. The developed composite can be used to manufacture plastic runway or rubber hose.
Synthesis of novel carvone (meth)acrylate monomers for the production of hydrophilic polymers with high terpene content
Authors: Montanari Ulisse , Taresco Vincenzo , Liguori Anna , Gualandi Chiara , Howdle Steven M 
Published: August 2020

AbstractThe terpene‐based monomers and polymers reported in the literature are mostly hydrophobic and this is limiting their use in aqueous environments. To address this drawback, we have developed a novel synthetic strategy to functionalise a model terpene monomer in order to improve hydrophilicity and the number of polar groups on the polymer side chains. To produce a highly hydrophilic monomer, carvone (meth)acrylate was chosen as the primary feedstock. Carvone has more functionalisable double bonds than other commercial cyclic terpenes and offers the potential for the maximum number of hydrophilic groups per monomer molecule. The monomers were homopolymerised and copolymerised to generate novel green hydrophilic and amphiphilic terpene‐based polymers which were characterised by 1H–13C NMR, gel permeation chromatography, TGA and DSC analyses. © 2020 Society of Industrial Chemistry