bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variáveis associadas a eventos adversos em neonatos com cateter central de inserção periférica
Authors: Prado Nanete  Caroline da Costa , Stefany da Costa Santos Rebecca , Hévillyn Silva Costa Almino Romanniny , Morais de Lima Dhyanine , Silva de Oliveira Sylvia , Augusto Rosendo da Silva Richardson 
Published: July 2020

Objetivo: Identificar los factores asociados con la aparición de eventos adversos en el catéter de inserción central periférica en recién nacidos.Métodos: Un estudio transversal con un enfoque cuantitativo realizado en una Unidad de Cuidados Intensivos Neonatales de un hospital de maternidad de referencia en atención materna e infantil de alto riesgo en el noreste de Brasil. Muestra de 108 neonatos recolectados de febrero a noviembre de 2016.Resultados: La prevalencia de eventos adversos en los recién nacidos fue del 53,70%, asociada a las siguientes variables: sexo masculino (p = 0,033), peso inferior a 2500 gramos (p = 0,003), inserción después de 48 horas (p = 0,027), más de tres intentos de punción (p = 0,024), dificultad de progresión del catéter (p = 0,040), presencia de intercurrencias durante la inserción del catéter (p = 0,027), sobre dos cambios de apósito = 0.009) y ubicación no central del dispositivo (p = 0.042).Conclusión: Los resultados indican la necesidad de estrategias para la prevención de eventos adversos, con énfasis en la educación continua y el mejoramiento de habilidades en la gestión de este dispositivo.
Objective: To identify the factors associated with the occurrence of adverse events by a peripherally inserted central catheter in newborns. Methods: A quantitative, cross-sectional study carried out in the Neonatal Intensive Care Unit of a reference maternity hospital in high-risk maternal and child care in Northeast Brazil. The sample of 108 neonates was collected from February to November 2016. Results: The prevalence of adverse events in newborns was 53.70%, associated with the following variables: male gender (p=0.033), weight below 2500 grams (p=0.003), insertion performed after 48 hours of life (p=0.027), more than three puncture attempts (p=0.024), difficulty in inserting the catheter (p=0.040), intercurrence during catheter insertion (p=0.027), over two dressing changes (p=0.009), and non-central position of the device (p=0.042). Conclusion: The results indicate the need for strategies to prevent adverse events, with emphasis on continuing education and on the improvement of skills regarding the use of this device.
Perfil clínico e demográfico de crianças e adolescentes portadores de estomia atendidos em serviço de referência - Clinical and demographic profile of children and adolescents with ostomy treated at a reference service
Authors: Koeppe Giselle Barcellos Oliveira , Ferreira Ariana Dias , Soares Jennifer Souza , Cerqueira Luciana Da Costa Nogueira , Torres Viviane Cristina da Paz , Oliveira Priscila Pradonoff 
Published: July 2020

Objetivo: levantar o perfil clínico-epidemiológico de crianças e adolescentes com estomia atendidos em um serviço de referência. Método: estudo descritivo, transversal e quantitativo realizado em 13 prontuários de crianças e adolescentes estomizados atendidos em serviço de referência. Resultados: 38,4% eram lactentes e 30,8% pré-escolares. 76,9% eram do sexo masculino, 53.8% eram brancos, 23,1% tem renda familiar de até um salário mínimo e 76,9% têm a mãe como cuidadora. 38,4% tem a imperfuração anal como a causa mais comum da estomia. 100% das crianças tem colostomia, 53,8% tem o estoma em caráter temporário e 46,2% apresentou a dermatite de contato como complicação. Conclusão: o estudo demonstrou uma prevalência de lactentes e pré-escolares, do sexo masculino, da raça branca. A imperfuração anal emergiu como a causa mais comum do estoma e a dermatite de contato foi considerada a complicação mais comum.
Drift‐Diffusion Study of the IQE Roll‐Off in Blue Thermally Activated Delayed Fluorescence OLEDs
Authors: Rossi Daniele , Palazzo Daniele , Di Carlo Aldo , Auf der Maur Matthias 
Published: July 2020

AbstractA detailed optical and electrical investigation of a blue thermally activated delayed fluorescence (TADF)‐based organic light emitting diode (OLED) is performed by drift‐diffusion simulations. Calculation of the charge transport of the different carrier populations in the device is used to predict and investigate the current–voltage characteristics and the resulting internal radiative emission profile. The explicit modeling of both singlet and exciton states of the TADF emitter combined with the inclusion of proper models for band‐to‐band transitions, bimolecular recombination mechanisms, and intersystem crossing allows to investigate the kinetics of fluorescence by thermal activation. The investigation provides insights into the role of triplet–triplet annihilation and triplet–polaron quenching for the roll‐off in internal quantum efficiency.
Scheduling of crude oil refinery operation with desalting as a separate task
Authors: Bayu Feleke , Shaik Munawar A. , Ramteke Manojkumar 
Published: July 2020

AbstractA crude oil refining is a capital intensive process and releases a huge amount of environmentally unfriendly side‐products. Scheduling of crude oil that determines the optimal unloading of crude from vessels to storages, transfer to blending tanks, and charging to distillation units (CDUs) in a way that minimizes the total operating cost has become the focus of the studies in the last few decades. In this paper, we present a model that extends the literature work of a unit‐specific event‐based model to incorporate desalting as a separate task and allows a desalting tank to feed multiple CDUs. The formulation is based on a state task network (STN) that uses a unit‐specific event‐based time representation. It considers different scenarios like simultaneous or sequential discharging of products and by‐products from a desalting tank and whether a desalting tank feeding to multiple CDUs is allowed simultaneously or not. The proposed model leads a step closure to the reality and enables to know the amount of wash water needed, and the sludge disposed off for treatment in addition to the ordinary crude oil scheduling formulation. The performance of the proposed formulation is demonstrated using four case studies.
Cross‐modal retrieval with dual multi‐angle self‐attention
Authors: Li Wenjie , Zheng Yi , Zhang Yuejie , Feng Rui , Zhang Tao , Fan Weiguo 
Published: July 2020

AbstractIn recent years, cross‐modal retrieval has been a popular research topic in both fields of computer vision and natural language processing. There is a huge semantic gap between different modalities on account of heterogeneous properties. How to establish the correlation among different modality data faces enormous challenges. In this work, we propose a novel end‐to‐end framework named Dual Multi‐Angle Self‐Attention (DMASA) for cross‐modal retrieval. Multiple self‐attention mechanisms are applied to extract fine‐grained features for both images and texts from different angles. We then integrate coarse‐grained and fine‐grained features into a multimodal embedding space, in which the similarity degrees between images and texts can be directly compared. Moreover, we propose a special multistage training strategy, in which the preceding stage can provide a good initial value for the succeeding stage and make our framework work better. Very promising experimental results over the state‐of‐the‐art methods can be achieved on three benchmark datasets of Flickr8k, Flickr30k, and MSCOCO.
Harnessing energy from Australian dairy waste: utilizing five methodologies
Authors: Arefin Md A. , Nabi Md N. , McIntosh Shane 
Published: July 2020

AbstractAs dairy industries increase across Australia, the amount of dairy waste is also on the rise. Australia annually production stands at around 377 727 t of cheese, 273 425 t of milk powder and 92 698 t of butter, and it is the third largest exporter of milk. The waste produced by these industries is considered a potentially valuable resource, and an environmental pollutant if not appropriately managed. The focus of this review is to evaluate the potential of converting typical Australian dairy industry waste into sustainable energy. Five fundamental methods including transesterification, pyrolysis, anaerobic digestion, steam reforming, and hydrothermal carbonization are discussed. Their technological merits, demerits and adaptability from the perspective of Australia are examined. The properties of representative wastes are also considered for the different energy conversion processes. This review aims to highlight the potential use of dairy industry wastes as feedstock for the emerging renewable energy sector. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd
A CFD model for predicting protein aggregation in low‐pH virial inactivation for mAb production
Authors: Xing Zizhuo , Jin Weixin , Xu Xuankuo , Song Yuanli , Huang Chao , Borys Michael C. , Ghose Sanchayita , Li Zheng Jian 
Published: July 2020

AbstractSignificant amounts of soluble product aggregates were observed in the low‐pH viral inactivation (VI) operation during an initial scale‐up run for an immunoglobulin‐G 4 (IgG4) monoclonal antibody (mAb IgG4‐N1). Being earlier in development, a scale‐down model did not exist, nor was it practical to use costly Protein A eluate (PAE) for testing the VI process at scale, thus, a computational fluid dynamics (CFD)‐based high‐molecular weight (HMW) prediction model was developed for troubleshooting and risk mitigation. It was previously reported that the IgG4‐N1 molecules upon exposure to low pH tend to change into transient and partially unfolded monomers during VI acidification (i.e., VIA) and form aggregates after neutralization (i.e., VIN). Therefore, the CFD model reported here focuses on the VIA step. The model mimics the continuous addition of acid to PAE and tracks acid distribution during VIA. Based on the simulated low‐pH zone (≤pH 3.3) profiles and PAE properties, the integrated low‐pH zone (ILPZ) value was obtained to predict HMW level at the VI step. The simulations were performed to examine the operating parameters, such as agitation speed, acid addition rate, and protein concentration of PAE, of the pilot scale (50–200 L) runs. The conditions with predictions of no product aggregation risk were recommended to the real scale‐up runs, resulted in 100% success rate of the consecutive 12 pilot‐scale runs. This study demonstrated that the CFD‐based HMW prediction model could be used as a tool to facilitate the scale up of the low‐pH VI process directly from bench to pilot/production scale.
Variation in descriptors of patient characteristics in randomized clinical trials of peptic ulcer repair: a systematic review
Authors: Lee M J , Coe P O , O'Donoghue R , Peirson M , Saha A 
Published: July 2020

Abstract

Background
The ability to compare findings across surgical research is important. Inadequate description of participants, interventions or outcomes could lead to bias and inaccurate assessment of findings. The aim of this study was to assess consistency of description of participants using studies comparing laparoscopic and open repair of peptic ulcer as an example.

Methods
This systematic review is reported in line with the PRISMA checklist. Searches of MEDLINE and Embase databases were performed to identify studies comparing laparoscopic and open repair of perforated peptic ulcer in adults, published in the English language. Manuscripts were dual-screened for eligibility. Full texts were retrieved and dual-screened for inclusion. Data extracted from studies included descriptors of participants in studies from tables and text. Descriptors were categorized into conceptual domains by the research team, and coverage of each domain by study was tabulated.

Results
Searches identified 2018 studies. After screening, 37 full texts were retrieved and 23 studies were included in the final synthesis. A total of 76 unique descriptors were identified. These were classified into demographics (11 descriptors), vital signs (9 descriptors), disease-specific characteristics (10 descriptors), presentation and pathway factors (4 descriptors), risk factors (8 descriptors), laboratory tests (14 descriptors) and baseline health (28 descriptors). The number of descriptors in a single study ranged from three to 31. All studies reported at least one demographic descriptor. Laboratory tests was the least frequently described domain.

Conclusion
Study participants are described inconsistently in studies of a single example surgical condition.
HaloTag‐Targeted Sirtuin‐Rearranging Ligand (SirReal) for the Development of Proteolysis‐Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)**
Authors: Schiedel Matthias , Lehotzky Attila , Szunyogh Sandor , Oláh Judit , Hammelmann Sören , Wössner Nathalie , Robaa Dina , Einsle Oliver , Sippl Wolfgang , Ovádi Judit , Jung Manfred 
Published: July 2020

AbstractWe have discovered the sirtuin‐rearranging ligands (SirReals) as a novel class of highly potent and selective inhibitors of the NAD+‐dependent lysine deacetylase sirtuin 2 (Sirt2). In previous studies, conjugation of a SirReal with a ligand for the E3 ubiquitin ligase cereblon to form a so‐called proteolysis‐targeting chimera (PROTAC) enabled small‐molecule‐induced degradation of Sirt2. Herein, we report the structure‐based development of a chloroalkylated SirReal that induces the degradation of Sirt2 mediated by Halo‐tagged E3 ubiquitin ligases. Using this orthogonal approach for Sirt2 degradation, we show that other E3 ligases than cereblon, such as the E3 ubiquitin ligase parkin, can also be harnessed for small‐molecule‐induced Sirt2 degradation, thereby emphasizing the great potential of parkin to be used as an E3 ligase for new PROTACs approaches. Thus, our study provides new insights into targeted protein degradation in general and Sirt2 degradation in particular.
COVID‐19 complicated by ST‐segment elevation myocardial infarction in a 29‐year‐old patient
Authors: Ong Emily , Castro‐Dominguez Yulanka , Brennan Joseph , Oen‐Hsiao Joyce 
Published: July 2020

AbstractWe describe a case in which a 29‐year‐old male with no medical history presented with ST‐segment elevation myocardial infarction as his presentation of coronavirus disease. During cardiac catheterization, he was found to have total occlusion of his left anterior descending artery by thrombus. Laboratory testing revealed markedly elevated inflammatory markers as well as evidence of a hypercoagulable state in the setting of severe acute respiratory syndrome coronavirus 2 infection, which was suspected to be the inciting factor for his acute coronary event.
Identifying the optimal donor for natural killer cell adoptive therapy to treat paediatric B‐ and T‐cell acute lymphoblastic leukaemia
Authors: Foley Bree , Ta Clara , Barnes Samantha , de Jong Emma , Nguyen Michelle , Cheung Laurence C , Buzzai Anthony , Wagner Teagan , Wylie Ben , Fernandez Sonia , Cruickshank Mark , Endersby Raelene , Kees Ursula , Waithman Jason 
Published: July 2020

AbstractObjectivesNatural killer (NK) cells are an attractive source of cells for an ‘off the shelf’ cellular therapy because of their innate capacity to target malignant cells, and ability to be transferred between donors and patients. However, since not all NK cells are equally effective at targeting cancer, selecting the right donor for cellular therapy is critical for the success of the treatment. Recently, cellular therapies utilising NK cells from cytomegalovirus (CMV)‐seropositive donors have been explored. However, whether these NK cells are the best source to treat paediatric acute lymphoblastic leukaemia (ALL) remains unclear.MethodsUsing a panel of patient‐derived paediatric B‐ and T‐ALL, we assessed the ability of NK cells from 49 healthy donors to mount an effective functional response against these two major subtypes of ALL.ResultsFrom this cohort, we have identified a pool of donors with superior activity against multiple ALL cells. While these donors were more likely to be CMV+, we identified multiple CMVneg donors within this group. Furthermore, NK cells from these donors recognised B‐ and T‐ALL through different activating receptors. Dividing functional NK cells into 29 unique subsets, we observed that within each individual the same NK cell subsets dominated across all ALL cells. Intriguingly, this occurred despite the ALL cells in our panel expressing different combinations of NK cell ligands. Finally, we can demonstrate that cellular therapy products derived from these superior donors significantly delayed leukaemia progression in preclinical models of ALL.ConclusionsWe have identified a pool of superior donors that are effective against a range of ALL cells, representing a potential pool of donors that can be used as an adoptive NK cell therapy to treat paediatric ALL.
An accumulation of climatic stress events has led to years of reduced growth for sugar maple in southern Quebec, Canada
Authors: Moreau Guillaume , Achim Alexis , Pothier David 
Published: July 2020

AbstractUnderstanding the influence of climatic variation on forest dynamics is of great ecological and economic interest, and is essential to prescribe silvicultural interventions that will facilitate ecosystem acclimation to global change. However, the retrospective identification of climatic events responsible for the inter‐annual variation of tree growth is challenging, notably because both their duration and their subsequent effects can be highly variable in time. In this study, we aimed to (1) quantify empirically the effect of climatic stress events on the short‐ and long‐term growth dynamics of sugar maple trees; (2) compare the effects of different types of climatic events, that is, drought and thaw–freeze; and (3) compare the effects of climatic stress events to those of traditional monthly level climate metrics. To achieve this, we paired cross‐dated tree‐ring series to monthly and daily‐level climate metrics over more than 50 yr in two distinct regions of southern Quebec. While the analysis from monthly level metrics first suggested a weak and non‐stationary relationship between climatic conditions and tree growth, the analysis from daily‐level metrics showed that climatic stress events, and more particularly thaw–freeze events, were strongly related to the growth of sugar maple trees. Our results suggest that the synergic influence of cumulative climatic stress events, which was exacerbated by insect outbreaks during the early 1980s, induced an important shift in the growth dynamics of sugar maple and in its response to variation in climatic conditions. These results highlight the potential negative impact of global climate change on our capacity to predict stand productivity accurately, especially if climate‐sensitive growth models are based on projections of future monthly metrics. Because adverse climatic events are expected to increase both in frequency and in severity over the next decades, a general decrease in the growth rate of sugar maple is apprehended in southern Quebec.
Experimental and numerical studies on buckling restrained braces with posttensioned carbon fiber composite cables
Authors: Atasever Kurtulus , Inanaga Shogo , Takeuchi Toru , Terazawa Yuki , Celik Oguz C. 
Published: July 2020

SummaryThere has been an increasing interest in using residual deformation as a seismic performance indicator for earthquake resistant building design. Self‐centering braced structural systems are viable candidates for minimizing residual deformations following a major earthquake. Hence, this study proposes an alternative type of buckling restrained brace (BRB) with externally attached posttensioned (PT‐BRB) carbon fiber composite cables (CFCCs). The steel core of the brace is used as an energy dissipator, whereas the CFCCs provide the self‐centering force for minimizing residual story drifts. Three proof‐of‐concept specimens are designed, fabricated, and cyclically tested at different posttensioning force levels. The CFCC behavior to obtain cyclic response, including the anchorage system, is examined closely. A parametric study is also conducted to show the effect of the different configurations of PT‐BRBs on the inelastic response. Furthermore, optimal brace parameters are discussed to realize design recommendations. The results indicated that the implementation of partially self‐centering BRBs in building frames can lead to the target residual displacements. A stable behavior is obtained for the proposed PT‐BRBs when subjected to the loading protocol specified in the American Institute of Steel Construction (AISC) 2016 Seismic Provisions.
Quantitative analysis of SmearOFF and different irrigation activation techniques on removal of smear layer: A scanning electron microscope study
Authors: Mobaraki Babak , Yeşildal Yeter Kübra 
Published: July 2020

AbstractThe aim of this study was to evaluate the effectiveness of SmearOFF solution on smear layer removal by using different irrigation activation techniques. One hundred and twenty mandibular premolars were decoronated, and instrumented with Reciproc up to size 50. Then, the specimens were divided into 6 groups according to the final irrigation activation technique: Group 1: SmearOFF + Conventional syringe irrigation (CSI); Group 2: SmearOFF + Sonic activation (SA); Group 3: SmearOFF + Passive ultrasonic activation (PUA); Group 4:17% EDTA + CSI; Group 5:17% EDTA + SA, and Group 6:17% EDTA + PUA. Teeth were split longitudinally, and specimens were observed under scanning electron microscope. Images were taken from the coronal, middle, and apical thirds of the teeth with 1,000× magnification and analyzed using ImageJ program to calculate total open dentinal tubule areas. Three‐way ANOVA test was applied to reveal any significant differences among solutions, activation techniques and root thirds. There was no statistically significant difference among the groups in terms of irrigation solutions (p > .05). There was a statistically significant difference between PUA and CSI groups (p < .05). However, no significant difference was observed between PUA and SA, or between SA and CSI (p > .05). All experimental procedures were most effective in the middle region of the root, followed by cervical and apical thirds (p < .05). PUA showed higher efficacy in smear layer removal compared with CSI. SmearOFF and 17% EDTA showed similar results. The best results in removing smear layer were obtained in the middle region of the root.