bluuebunny/crossref_metadata_2025_split huggingface dataset:
SALADIN'S ‘SPIN DOCTORS’
Authors: Hillenbrand Carole 
Published: November 2019

ABSTRACTWe might flatter ourselves that the idea of a spin doctor is rather a modern one, but I wonder. Obviously enough, powerful rulers have always had their coterie of close advisers. But in the medieval Muslim world there is one outstanding example of something rather more than this: the team of three counsellors that Saladin assembled who watched over his interests and, crucially, his reputation, with unflagging devotion for decades. Two of them were, by any standard, intellectual stars who could have turned their multifarious talents in many directions but who chose rather to dedicate them to a man whom they not only admired but also loved. One of them, the poet ‘Imad al-Din al-Isfahani, was a Persian with a truly awesome command of Arabic, a gift which he delighted to exhibit in and out of season. His pyrotechnic performances, solid with metaphor, saturated with puns, wordplay, alliteration, assonance and verbal acrobatics, are such a nightmare to understand that generations of Western Orientalists – and indeed Arab scholars too, for that matter – have recoiled from the task of editing certain of his works. Sometimes in his writings manner eclipses matter, but he is also capable of reaching heights of solemn eloquence, as in his paean of triumph at the recapture of Jerusalem, or his threnody on the death of Saladin. The other, the Qadi al-Fadil – his title means ‘The Excellent Judge’ – though only a somewhat pedestrian poet, was an acknowledged master of the epistolary prose that was de rigueur in Islamic chanceries, and for centuries his letters were regarded as models of their genre. His appearance, hunchbacked and skeletal, made him the butt of the court's satirical poets, but his political skills were beyond reproach, and indeed in his master's absence he governed Egypt for a time. It has been said that biography adds an extra terror to death, but in that respect Saladin need not have worried. For Ibn Shaddad, the third member of this distinguished triumvirate, who joined the team after the fall of Jerusalem but thereafter never left Saladin's side and therefore saw him in good times and bad, was a plain man with a plain style. But he rose to the occasion and crafted a biography of his hero Saladin that lets the facts speak for themselves. He has no time for stale panegyric; instead, his admiration for Saladin shines through his account at every turn, and it is he who laid the foundations for his master's posthumous celebrity. The lecture will explore the impact of these three men on the Saladin legend, which transformed a minor Kurdish warlord into an emblem of chivalry, piety and military glory which captured the hearts and the imaginations of Muslims for centuries to come – and still does.
LOVE, CARE AND THE ILLEGITIMATE CHILD IN EIGHTEENTH-CENTURY SCOTLAND
Authors: Barclay Katie 
Published: November 2019

ABSTRACTThis article uses a combination of court and Kirk (Church of Scotland) session records, and several sets of letters written by the mothers of illegitimate children to explore how such children were loved and cared for in eighteenth-century Scotland. It argues that legitimacy, as well as class and gender, mattered in the love and care that children received. Illegitimacy also had an impact on who mothered, fracturing the bond between the biological mother and child, for a mothering given by other mothers, including wet-nurses, grandparents and, later, employers. Its conclusion is that how a child was mothered, the love and care they received, were products of a child's positioning – gender, class, legitimacy, parentage – in the world. Love was a social product, framed and shaped by and through the social, economic and legal networks in which the child was positioned. Whilst the legitimate child, both in law and social practice, might have expected its care to be framed primarily through the nuclear family, the bastard child belonged, as the law suggested, to the community, requiring its mothering to be dispersed.
TIME AND DISTANCE: REFLECTIONS ON LOCAL AND GLOBAL HISTORY FROM EAST AFRICA
Authors: Reid Richard 
Published: November 2019

ABSTRACTThis paper is concerned with East Africans’ perceptions of the intersection between their own, highly charged and contested, local histories, and the global past, as well as their place in it. The two case studies on which the paper is based – Eritrea and Uganda – have much in common in terms of recent history, not least in their experience of prolonged violence, and thus taken together they elucidate distinctive characteristics. Yet they also illustrate broader phenomena. On one level, particular interpretations of local history – both the deeper, precolonial past and the more recent, twentieth-century past – are utilised tocritiquethe flow of global history, as well as the impositions of globalisation, and to emphasise the bitter experience of marginality and lack of agency. At the same time, the global past – conceptualised as the evolution of an intrusive, imperialist, hypocritical global order imposed by foreigners, usually Western in provenance – is seen as omnipresent and pervasive, and thus the arguments made around marginality serve to remind us, paradoxically, howcentralthese communities are (or should be) to the framing of global history.
Variations in the Ionospheric Peak Altitude at Mars in Response to Dust Storms: 13 Years of Observations From the Mars Express Radar Sounder
Authors: Girazian Z. , Luppen Z. , Morgan D. D. , Chu F. , Montabone L. , Thiemann E. M. B. , Gurnett D. A. , Halekas J. , Kopf A. J. , Němec F. 
Published: November 2019

AbstractPrevious observations have shown that, during Martian dust storms, the peak of the ionosphere rises in altitude. Observational studies of this type, however, have been extremely limited. Using 13 years of ionospheric peak altitude data from the Mars Advanced Radar for Subsurface and Ionosphere Sounding instrument on Mars Express, we study how the peak altitude responded to dust storms during six different Mars years (MY). The peak altitude increased ∼10–15 km during all six events, which include a local dust storm (MY 33), three regional dust storms (MYs 27, 29, and 32), and two global dust storms (MYs 28 and 34). The peak altitude's orbit‐to‐orbit variability was exceptionally large at the apexes of the MY 29 and MY 32 dust seasons and dramatically increased during the MY 28 and MY 34 global dust storms. We conclude that dust storms significantly increase upper atmospheric variability, which suggests that they enhance dynamical processes that couple the lower and upper atmospheres, such as upward propagating gravity waves or atmospheric tides.
Controlled synthesis of a core-shell nanohybrid for effective multimodal image-guided combined photothermal/photodynamic therapy of tumors
Authors: Cheng Qian , Li Zi-Hao , Sun Yun-Xia , Zhang Xian-Zheng 
Published: November 2019

AbstractIn this paper, a simple strategy is proposed to prepare a core-shell nanohybrid (PB@PCN) by the controllable coating of zirconium-porphyrin (PCN) shells on Prussian blue (PB) nanoparticles. By adjusting the thickness of the PCN shell, the PB@PCN nanohybrid with the best comprehensive performance was obtained for tumor treatment and imaging. The integrated nanosystem as a tandem catalyst is able to convert H2O2 to O2 through the PB core, and then the O2 is directly injected into the PCN framework, leading to a high quantum yield of singlet oxygen to kill tumor cells and attack heat shock proteins (HSPs). The nanohybrid was further camouflaged by a tumor cell membrane (PB@PCN@MEM) with good immune evasion and active targeting ability. Upon accumulation at the tumor site, PN@PCN@MEM showed an enhanced photodynamic therapeutic effect against hypoxic tumor cells. Furthermore, coupled with the photothermal therapy of PB, photothermal/photodynamic synergistic therapy of tumors can be realized. In addition, due to its excellent imaging performance, this core-shell nanohybrid can be employed for the multimodal image-guided therapy of tumors.
Neratinib protects pancreatic beta cells in diabetes
Authors: Ardestani Amin , Li Sijia , Annamalai Karthika , Lupse Blaz , Geravandi Shirin , Dobrowolski Aleksandra , Yu Shan , Zhu Siying , Baguley Tyler D. , Surakattula Murali , Oetjen Janina , Hauberg-Lotte Lena , Herranz Raquel , Awal Sushil , Altenhofen Delsi , Nguyen-Tran Van , Joseph Sean , Schultz Peter G. , Chatterjee Arnab K. , Rogers Nikki , Tremblay Matthew S. , Shen Weijun , Maedler Kathrin 
Published: November 2019

AbstractThe loss of functional insulin-producing β-cells is a hallmark of diabetes. Mammalian sterile 20-like kinase 1 (MST1) is a key regulator of pancreatic β-cell death and dysfunction; its deficiency restores functional β-cells and normoglycemia. The identification of MST1 inhibitors represents a promising approach for a β-cell-protective diabetes therapy. Here, we identify neratinib, an FDA-approved drug targeting HER2/EGFR dual kinases, as a potent MST1 inhibitor, which improves β-cell survival under multiple diabetogenic conditions in human islets and INS-1E cells. In a pre-clinical study, neratinib attenuates hyperglycemia and improves β-cell function, survival and β-cell mass in type 1 (streptozotocin) and type 2 (obese Leprdb/db) diabetic mouse models. In summary, neratinib is a previously unrecognized inhibitor of MST1 and represents a potential β-cell-protective drug with proof-of-concept in vitro in human islets and in vivo in rodent models of both type 1 and type 2 diabetes.
Rice production threatened by coupled stresses of climate and soil arsenic
Authors: Muehe E. Marie , Wang Tianmei , Kerl Carolin F. , Planer-Friedrich Britta , Fendorf Scott 
Published: November 2019

AbstractProjections of global rice yields account for climate change. They do not, however, consider the coupled stresses of impending climate change and arsenic in paddy soils. Here, we show in a greenhouse study that future conditions cause a greater proportion of pore-water arsenite, the more toxic form of arsenic, in the rhizosphere of Californian Oryza sativa L. variety M206, grown on Californian paddy soil. As a result, grain yields decrease by 39% compared to yields at today’s arsenic soil concentrations. In addition, future climatic conditions cause a nearly twofold increase of grain inorganic arsenic concentrations. Our findings indicate that climate-induced changes in soil arsenic behaviour and plant response will lead to currently unforeseen losses in rice grain productivity and quality. Pursuing rice varieties and crop management practices that alleviate the coupled stresses of soil arsenic and change in climatic factors are needed to overcome the currently impending food crisis.
Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks
Authors: Wei Tz-Han , Wu Shi-Hong , Huang Yi-Da , Lo Wei-Shang , Williams Benjamin P. , Chen Sheng-Yu , Yang Hsun-Chih , Hsu Yu-Shen , Lin Zih-Yin , Chen Xin-Hua , Kuo Pei-En , Chou Lien-Yang , Tsung Chia-Kuang , Shieh Fa-Kuen 
Published: November 2019

AbstractMetal–organic frameworks (MOFs) have recently garnered consideration as an attractive solid substrate because the highly tunable MOF framework can not only serve as an inert host but also enhance the selectivity, stability, and/or activity of the enzymes. Herein, we demonstrate the advantages of using a mechanochemical strategy to encapsulate enzymes into robust MOFs. A range of enzymes, namely β-glucosidase, invertase, β-galactosidase, and catalase, are encapsulated in ZIF-8, UiO-66-NH2, or Zn-MOF-74 via a ball milling process. The solid-state mechanochemical strategy is rapid and minimizes the use of organic solvents and strong acids during synthesis, allowing the encapsulation of enzymes into three prototypical robust MOFs while maintaining enzymatic biological activity. The activity of encapsulated enzyme is demonstrated and shows increased resistance to proteases, even under acidic conditions. This work represents a step toward the creation of a suite of biomolecule-in-MOF composites for application in a variety of industrial processes.
Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
Authors: Reed Michelle , Luissint Anny-Claude , Azcutia Veronica , Fan Shuling , O’Leary Monique N. , Quiros Miguel , Brazil Jennifer , Nusrat Asma , Parkos Charles A. 
Published: November 2019

AbstractCD47 is a ubiquitously expressed transmembrane glycoprotein that regulates inflammatory responses and tissue repair. Here, we show that normal mice treated with anti-CD47 antibodies, andCd47-null mice have impaired intestinal mucosal wound healing. Furthermore, intestinal epithelial cell (IEC)-specific loss of CD47 does not induce spontaneous immune-mediated intestinal barrier disruption but results in defective mucosal repair after biopsy-induced colonic wounding or Dextran Sulfate Sodium (DSS)-induced mucosal damage. In vitro analyses using primary cultures of CD47-deficient murine colonic IEC or human colonoid-derived IEC treated with CD47-blocking antibodies demonstrate impaired epithelial cell migration in wound healing assays. Defective wound repair after CD47 loss is linked to decreased epithelial β1 integrin and focal adhesion signaling, as well as reduced thrombospondin-1 and TGF-β1. These results demonstrate a critical role for IEC-expressed CD47 in regulating mucosal repair and raise important considerations for possible alterations in wound healing secondary to therapeutic targeting of CD47.
Seasonal dynamics of stem N2O exchange follow the physiological activity of boreal trees
Authors: Machacova Katerina , Vainio Elisa , Urban Otmar , Pihlatie Mari 
Published: November 2019

AbstractThe role of trees in the nitrous oxide (N2O) balance of boreal forests has been neglected despite evidence suggesting their substantial contribution. We measured seasonal changes in N2O fluxes from soil and stems of boreal trees in Finland, showing clear seasonality in stem N2O flux following tree physiological activity, particularly processes of CO2 uptake and release. Stem N2O emissions peak during the vegetation season, decrease rapidly in October, and remain low but significant to the annual totals during winter dormancy. Trees growing on dry soils even turn to consumption of N2O from the atmosphere during dormancy, thereby reducing their overall N2O emissions. At an annual scale, pine, spruce and birch are net N2O sources, with spruce being the strongest emitter. Boreal trees thus markedly contribute to the seasonal dynamics of ecosystem N2O exchange, and their species-specific contribution should be included into forest emission inventories.
Two-electron transfer stabilized by excited-state aromatization
Authors: Kim Jinseok , Oh Juwon , Park Seongchul , Zafra Jose L. , DeFrancisco Justin R. , Casanova David , Lim Manho , Tovar John D. , Casado Juan , Kim Dongho 
Published: November 2019

AbstractThe scientific significance of excited-state aromaticity concerns with the elucidation of processes and properties in the excited states. Here, we focus on TMTQ, an oligomer composed of a central 1,6-methano[10]annulene and 5-dicyanomethyl-thiophene peripheries (acceptor-donor-acceptor system), and investigate a two-electron transfer process dominantly stabilized by an aromatization in the low-energy lying excited state. Our spectroscopic measurements quantitatively observe the shift of two π-electrons between donor and acceptors. It is revealed that this two-electron transfer process accompanies the excited-state aromatization, producing a Baird aromatic 8π core annulene in TMTQ. Biradical character on each terminal dicyanomethylene group of TMTQ allows a pseudo triplet-like configuration on the 8π core annulene with multiexcitonic nature, which stabilizes the energetically unfavorable two-charge separated state by the formation of Baird aromatic core annulene. This finding provides a comprehensive understanding of the role of excited-state aromaticity and insight to designing functional photoactive materials.
Atomic mechanism of strong interactions at the graphene/sapphire interface
Authors: Dou Zhipeng , Chen Zhaolong , Li Ning , Yang Shenyuan , Yu Zhiwei , Sun Yuanwei , Li Yuehui , Liu Bingyao , Luo Qiang , Ma Tianbao , Liao Lei , Liu Zhongfan , Gao Peng 
Published: November 2019

AbstractFor atomically thin two-dimensional materials, interfacial effects may dominate the entire response of devices, because most of the atoms are in the interface/surface. Graphene/sapphire has great application in electronic devices and semiconductor thin-film growth, but the nature of this interface is largely unknown. Here we find that the sapphire surface has a strong interaction with some of the carbon atoms in graphene to form a C-O-Al configuration, indicating that the interface interaction is no longer a simple van der Waals interaction. In addition, the structural relaxation of sapphire near the interface is significantly suppressed and very different from that of a bare sapphire surface. Such an interfacial C-O-Al bond is formed during graphene growth at high temperature. Our study provides valuable insights into understanding the electronic structures of graphene on sapphire and remote control of epitaxy growth of thin films by using a graphene–sapphire substrate.
Topological phases in pyrochlore thallium niobate Tl2Nb2O6+x
Authors: Zhang Wei , Luo Kaifa , Chen Zhendong , Zhu Ziming , Yu Rui , Fang Chen , Weng Hongming 
Published: November 2019

AbstractThe discovery of new topological electronic materials brings a chance to uncover new physics. Up to now, many materials have been theoretically proposed and experimentally proved to host different kinds of topological states. Unfortunately, there is little convincing experimental evidence for the existence of topological oxides. The reason is that oxidation of oxygen leads to ionic crystal in general and makes band inversion unlikely. In addition, the realization of different topological states in a single material is quite difficult, but strongly needed for exploring topological phase transitions. In this work, using first-principles calculations and symmetry analysis, we propose that the experimentally tunable continuous solid solution of oxygen in pyrochlore Tl2Nb2O6+x (0 ≤ x ≤ 1.0) leads to various topological states. Topological insulator, Dirac semimetal, and triply degenerate nodal point semimetal can be realized in it via changing the oxygen content and/or tuning the crystalline symmetries. When x = 1, it is a semimetal with quadratic band touching point at Fermi level. It transits into a Dirac semimetal or a topological insulator depending on the in-plane strain. When x = 0.5, the inversion symmetry is spontaneously broken in Tl2Nb2O6.5, leading to triply degenerate nodal points. When x = 0, Tl2Nb2O6 becomes a trivial insulator with a narrow band gap. These topological phase transitions driven by solid solution of oxygen are unique and physically plausible due to the variation of valence state of Tl+ and Tl3+. This topological oxide will be promising for studying correlation induced topological states and potential applications.
Computational framework chinook for angle-resolved photoemission spectroscopy
Authors: Day Ryan P. , Zwartsenberg Berend , Elfimov Ilya S. , Damascelli Andrea 
Published: November 2019

AbstractWe have developed the numerical software package chinook for the simulation of photoemission matrix elements. This quantity encodes a depth of information regarding the orbital structure of the underlying wavefunctions from which photoemission occurs. Extraction of this information is often nontrivial, owing to the influence of the experimental geometry and photoelectron interference, precluding straightforward solutions. The chinook code has been designed to simulate and predict the ARPES intensity measured for arbitrary experimental configuration, including photon-energy, polarization, and spin-projection, as well as consideration of both surface-projected slab and bulk models. This framework then facilitates an efficient interpretation of the ARPES, allowing for a deeper understanding of the electronic structure in addition to the design of new experiments which leverage the matrix element effects towards the objective of selective photoemission from states of particular interest.
Wide-area low-energy surface stimulation of large mammalian ventricular tissue
Authors: Moreno Angel , Walton Richard D. , Constantin Marion , Bernus Olivier , Vigmond Edward J. , Bayer Jason D. 
Published: November 2019

AbstractThe epicardial and endocardial surfaces of the heart are attractive targets to administer antiarrhythmic electrotherapies. Electrically stimulating wide areas of the surfaces of small mammalian ventricles is straightforward given the relatively small scale of their myocardial dimensions compared to the tissue space constant and electrical field. However, it has yet to be proven for larger mammalian hearts with tissue properties and ventricular dimensions closer to humans. Our goal was to address the feasibility and impact of wide-area electrical stimulation on the ventricular surfaces of large mammalian hearts at different stimulus strengths. This was accomplished by placing long line electrodes on the ventricular surfaces of pig hearts that span wide areas, and activating them individually. Stimulus efficacy was assessed and compared between surfaces, and tissue viability was evaluated. Activation time was dependent on stimulation strength and location, achieving uniform linear stimulation at 9x threshold strength. Endocardial stimulation activated more tissue transmurally than epicardial stimulation, which could be considered a potential target for future cardiac electrotherapies. Overall, our results indicate that electrically stimulating wide areas of the ventricular surfaces of large mammals is achievable with line electrodes, minimal tissue damage, and energies under the human pain threshold (100 mJ).
Removal of deep-sea sponges by bottom trawling in the Flemish Cap area: conservation, ecology and economic assessment
Authors: Pham C. K. , Murillo F. J. , Lirette C. , Maldonado M. , Colaço A. , Ottaviani D. , Kenchington E. 
Published: November 2019

AbstractDeep-sea sponge grounds are vulnerable marine ecosystems, which through their benthic-pelagic coupling of nutrients, are of functional relevance to the deep-sea realm. The impact of fishing bycatch is here evaluated for the first time at a bathyal, sponge-dominated ecosystem in the high seas managed by the Northwest Atlantic Fisheries Organization. Sponge biomass surface created from research survey data using random forest modeling revealed 231,136 t of sponges in the area. About 42% of that biomass was protected by current fisheries closures. However, projections of trawling tracks estimated that the sponge biomass within them would be wiped out in just 1 year by the current level of fishing activity if directed on the sponges. Because these sponges filter 56,143 ± 15,047 million litres of seawater daily, consume 63.11 ± 11.83 t of organic carbon through respiration, and affect the turnover of several nitrogen nutrients, their removal would likely affect the delicate ecological equilibrium of the deep-sea benthic ecosystem. We estimated that, on Flemish Cap, the economic value associated with seawater filtration by the sponges is nearly double the market value of the fish catch. Hence, fishery closures are essential to reach sponge conservation goals as economic drivers cannot be relied upon.