bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practical issues in conducting multinational, multicenter trials managed by Contract Research Organisations
Authors: Placchi M 
Published: April 2020

Large multinational, multicenter trials are increasingly being performed during Phase III of the clinical development of a psychotropic drug to demonstrate the efficacy of the new therapeutic agent in the shortest possible time. The testing of the new drug therapy under a common protocol, foreseeing the combination of clinical data collected across countries for a joint evaluation, is becoming more frequent in drug development. Usually, Sponsors use the services of Contract Research Organisations (CROs) to undertake and manage such large multinational, multicenter trials.The Sponsor who is setting up large definitive CRO-managed studies with psychotropics may anticipate to encounter issues along the following lines: Psychiatric Practice, Organization and Logistics, Data Integration and Manpower.
A family interview study of schizophrenia, schizoaffective disorder, and major mood disorder: updated findings
Authors: Pope HG , Yurgelun-Todd D 
Published: April 2020

SummaryData from an ongoing family interview study suggest that schizoaffective probands - including even those with a very brief history of a major depressive or manic syndrome - display a high prevalence of major mood disorders in their first-degree relatives. In this respect, schizoaffective probands proved significantly different from ‘pure’ schizophrenic probands, but not significantly different from bipolar probands.
Symptomatic and diagnostic stability in schizophrenia: a one-year follow-up study
Authors: Dollfus S , Petit M , Menard JF , Lesieur P 
Published: April 2020

SummaryThe stability of symptomatology and of eleven schizophrenic diagnostic systems was studied in patients initially in an acute phase (group 1) compared to patients in a residual phase (group 2). The patients were evaluated over a period of 1 year with a standardized checklist and PANSS in both groups. The number of patients included by the Carpenter, Calego, 1CD9, New-Haven, Schneider and Vienne systems decreased significantly between admission and discharge in group 1, whereas no variation was observed in group 1 between discharge and one year later, or in group 2 over a period of 1 year. The instability of schizophrenic diagnostic systems such as New-Haven, Schneider and Vienne could be due to the variation of positive or general symptomatology. The number of patients included by Feighner or Langfeldt did not vary significantly between admission and discbarge in group 1, in spite of a significant decrease in symptomatology, probably because certain criteria, such as duration of illness, hindered the systems from changing. The results showed the importance of specifying in every study on schizophrenia the time of inclusion (admission, discharge) or the phase of illness (acute or residual phase).
Depressive symptoms and suicidal behavior among general population adolescents and young adults across Greece
Authors: Madianos MG , Gefou-Madianou D , Stefanis CN 
Published: April 2020

SummaryThe authors conducted a home survey investigating the prevalence of self-reported symptoms of depression, suicidal ideation and suicidal attempts among a probability nationwide sample of 1316 adolescents aged 12-17 and 1114 young adults aged 18-24. Depressive symptoms were detected by the use of the Center for Epidemiologic Studies-Depression scale. 20.3% of adolescents and 35.7% of young adults were characterized as being depressed. Similar differences between the two age groups in the prevalence rates of suicidal ideation and attempts were observed. Suicide attempters of both age groups reported a higher number of depressive symptoms compared with the non attempters. Characteristics that distinguished the suicide attempters from the total sample were low rates of school attendance, use of substances, previous psychiatric help-seeking and additional mental health problems in families.
Schizophrenia and symptomatic trans-sexualism: two case reports
Authors: de Cuypere G 
Published: April 2020

SummarySchizophrenics with “symptomatic trans-sexualism” may present themselves with the request for sex reassignment surgery. Two case reports illustrate that DSM III-R diagnosis for trans-sexualism offers insufficient guidelines for therapy management. The relation between schizophrenia and trans-sexualism is discussed.
Influence of psychoanalytical training on professional performance in a sample of French speaking psychotherapists
Authors: Dazord A , Gerin P , Davis JD , Davis ML , Aapro N , Thurin J 
Published: April 2020

SummaryThis study is part of a more extensive research conducted by a group of scientists from different countries, who have joined forces to conduct an international study on the development of the therapist, and to develop a novel instrument for therapists, the “Development of Psychotherapists’ Common Core Questionnaire” (CCQ). We report here the results based on the answers of a French-speaking sample to this questionnaire. Data were analyzed using univariate (non parametric tests) and multivariate analyses (Principal Component Analysis and Multiple Correspondence Analysis). The perceived effects of psychoanalytical training were examined. The therapists’ own perception on their current skills and the type of difficulties they experienced were very similar, whether or not they had received psychoanalytical training. However, striking and significant differences in coping strategies were observed between the two groups.
The relationship between “chronic hallucinatory psychosis” (CHP) and schizophrenia
Authors: Dollfus S , Petit M , Menard JF 
Published: April 2020

SummaryChronic Hallucinatory Psychosis (CHP) is typically a French disease entity initially described by G Ballet (1911) and whose diagnostic criteria were established by Pull (1987). This diagnosis is not used in English and German literature. The aim of this study was to investigate the relationship between Pull's criteria for CHP and the criteria for schizophrenia defined by 14 different diagnostic systems and schizoaffective disorders. Seventy-two non-affective psychotic patients (34 men, 38 women), aged 20 to 84, in exacerbated or stabilized phase, were interviewed by the same investigator (SD). The patient distribution between the diagnoses in the different diagnostic systems was carried out using a computerized 208-item checklist. The main results indicated that the definite CHP diagnosis was significantly related to the Catego S + (C = 0.52; P < 0.01), New-Haven, (C = 0.40; P < 0.05) and Schneider (C = 0.54; P < 0.001) systems for schizophrenia and with the depressive-schizoaffective disorder (C =0.39; P < 0.05) in the RDC system. The probable CHP diagnosis was significantly linked with the same systems and with the probable RDC (C = 0.39; P < 0.05) for schizophrenia. These results emphasize that in 13 out of the 14 diagnostic systems, schizophrenic and schizoaffective disorders overlapped with CHP in the French diagnostic system. Among these systems, four schizophrenic diagnoses were significantly linked to CHP. In contrast, the Bleuler system for schizophrenia was not related to CHP at all.
ICD-10: A field study in a Danish child psychiatric unit
Authors: Hove Thomsen P , Jørgensen J , Jørgen Nedergaard N 
Published: April 2020

SummaryNine raters applied ICD-10 diagnoses on 36 Danish child and adolescent psychiatric patients by screening their case records and using the DCR of ICD-10. The highest inter-rater agreement was obtained In the group of adolescent patients, the lowest was observed in emotional disorders in children. The comments on ICD-10 were generally positive but we support the creation of a category for the borderline children, and for the non-hyperactive children with attention deficit disorder.
Use of light therapy in German psychiatric hospitals
Authors: Kasper S , Ruhrmann S , Neumann S , Möller HJ 
Published: April 2020

SummaryIn order to determine the usage pattern of light therapy (LT), we performed a survey of all psychiatric hospitals in Germany in 1992. Our data reveal that 13% of all psychiatric hospitals perform LT and another 7% indicate their interest in this treatment. Stratification into different treatment facilities demonstrates that 57% of the psychiatric university hospitals use LT. The usage of LT started in Germany in 1982 and there was a sharp rise from 1987 onwards. The majority of hospitals (89% of those hospitals which use LT) use LT successfully for the treatment of seasonal affective disorder (SAD) and its subsyndromal form followed by non-SAD depression (68%). LT is used as monotherapy in 71% of SAD patients compared with 34% in non-SAD depression.
Measuring patient response biases by means of a new self-rated questionnaire evaluating severity of depression
Authors: Brébion J , Smith M , Allilaire JF 
Published: April 2020

SummaryWe present here a new instrument of measurement for systematic biases in patient response style when evaluating severity of depression, in the form of a self-rated questionnaire derived from the MMPI containing 37 items rating depressive severity (DSS), 15 items of the L scale, 27 items of the K scale, and 51 items of the F scale, making a total of 130 yes-no items. The scores of these 4 scales allow an estimation not only of depressive severity, but also of the attitude of the subject towards his own style of symptom reporting: “defense” and desire to appear “normal”, or on the contrary tendency towards exaggeration. In a population of 66 depressives, this instrument was correlated with the MADRS depression rating scale (P < 0.0001), which shows its sensitivity to depressive severity. The F scale and Gough’s index (F-K) were also shown to be correlated with MADRS scores. This self-rated questionnaire constitutes a clinical instrument that is simple and practical both to administer and to correct.
The relationship between obsessive-compulsive personality and obsessive-compulsive disorder: data obtained by the Personality Disorder Examination
Authors: Cassano D , Del Buono G , Catapano F 
Published: April 2020

SummaryWe administered the Personality Disorder Examination (PDE) to 31 patients meeting DSM III criteria for obsessive-compulsive disorder (OCD) and to an age-and sex-matched healthy control group. Seventeen patients (54.8%) and four controls (12.9%) met criteria for one or more DSM III Axis II diagnoses. The most frequent Axis II diagnoses in patients were avoidant, passive-aggressive and compulsive personality disorder. Compulsive personality disorder was diagnosed in 6 OCD patients (19.3%). The prevalence of this disorder did not change according to sex, age of onset or duration of OCD, and severity of obsessive-compulsive symptoms.
Quantitative EEG findings in patients with subcortical vascular encephalopathy
Authors: Primavera A , Novello P 
Published: April 2020

SummaryTo characterize the neurophysiological profile of patients with Subcortical Vascular Encephalopathy (SVE) we compared the quantified electroencephalogram (qEEG) of 15 consecutive patients, demented and non-demented, with leukoaraiosis and multiple lacunar infarcts on tomographic scan and magnetic resonance investigation, with those of 30 patients with Alzheimer’s disease (AD) and 30 controls. The investigation was carried out using an EEG fast Fourier transform program, and the data obtained were transformed into mean frequency (MF), calculated in the left occipital derivation, and in percent difference (PD), calculated in eight derivations. The data obtained were compared with the scores of the mini-mental state examination (MMS). The results demonstrate that the patients with SVE displayed a different qEEG pattern in comparison with AD patients and controls, with a prevalence of EEG slowing in frontal derivations, and with good correlation between PD values and MMS scores. The qEEG may detect subtle and/or early changes in patients with SVE. The use of adequate spectral parameters may give valuable data for a better classification of dementia syndromes.
Prevalence of anxiety and depressive symptoms in a high-school students population
Authors: Angelopoulos N , Economou M 
Published: April 2020

SummaryThe purpose of the present study was to examine the prevalence of symptoms of anxiety and depression reported by high-school students of a Greek provincial town. One thousand and eighty students (587 males and 497 females) of the 10th, 11th, and 12th grades completed among other psychometric instruments, the DSSI/sAD (Delusions Symptoms States Inventory/states of Anxiety and Depression) an inventory measuring symptoms of anxiety and depression. On the anxiety scale 24.5% of males and 56.4% of the females reported scores above the cut-off point, whereas 10.3% of males and 30.9% of females were very high scorers. On the depression scale, 33.4% of males and 60.6% of females reported scores above the cut-off point, whereas 13.9% of the boys and 31.1% of girls reported very high scores. Both boys and girls reported more elevated scores on the depression scale but the sex differences were more pronounced on the anxiety scale particularly in the group of high scorers. A weak positive relationship between age and dysthymic symptoms was detected in females. The findings encourage discussion on topics regarding not only the prevalence of anxiety and depressive symptoms in adolescence, but also the gender differences detected, the relationship between age and mood disorders in adolescence, the degree of diagnostic certainty of the self-report instrument used and the possible meaning of the low, medium, and high scores reported by the participants. It is proposed that data of this kind may be of some value in future comparative studies regarding small European cities.
Efficacy of clozapine in treatment-resistant psychosis and neuroleptic sensitivity: results of the Dutch open multi-center project
Authors: Verhoeven WMA , Doesburg WH , Snoej R , Rutgers AJMP , van Dongen PHM 
Published: April 2020

SummaryIn an open multi-center study, 57 schizophrenic patients were treated with clozapine for indications of treatment-resistant psychosis or severe extrapyramidal side-effects caused by conventional neuroleptics. In 58% of the patients a clinical relevant improvement, expressed as percentage reduction of at least 50 from baseline BPRS scores was observed. With respect to extrapyramidal side-effects, a marked reduction was found upon treatment with clozapine. No major side-effects occurred, particularly agranulocytosis. It was concluded that clozapine is a potent antipsychotic agent that can be used safely when treatment is accompanied by frequent clinical and hematological monitoring.
Cross-cultural validity of the Sensation Seeking Scale: development of a French abbreviated form
Authors: Carton S , Jouvent R , Widlöcher D 
Published: April 2020

SummaryThis study presents the principal component analysis of Zuckerman’s Sensation Seeking Scale (SSS form IV - 72 items). The results of the analysis of the French form support the existence of the four distinct dimensions of sensation seeking identified by Zuckerman, and replicated in a large number of studies. On the basis of this structure, an abbreviated form of the scale (40 items) has been constructed. It ressembles Zuckerman’s SSS form V. Attention is drawn to items that do not load significantly on the expected factor. The shorter form should be more useful in following-up research on sensation seeking in psychopathology.
Antidepressive effects of the selective MAO-inhibitor brofaromine:an open trial
Authors: Verhoeven WMA 
Published: April 2020

SummaryIn an open prospective study, the antidepressive effects of the selective and reversible MAO-A inhibitor, brofaromine, were investigated in nine endogenous depressed patients, who had failed to respond to cyclic antidepressants. In three patients a clinically relevant improvement was observed, although for the total group, no statistically significant treatment effect could be demonstrated. In two subjects, postural hypotension and sleep disturbances occurred temporarily.
The assessment of agoraphobic attitudes
Authors: Faravelli C , Paterniti S 
Published: April 2020

SummaryThe Phobic Attitude Scale (PAS) is a new 15-item inventory designed to assess sub-clinical agoraphobic attitudes as well as the severity of pathological avoidance. Its psychometric properties have been examined in three groups of subjects: 41 outpatients suffering from DSM III-R Panic Disorder, with or without agoraphobia, 62 healthy controls and 12 mixed psychiatric patients.The instrument proved to be simple and easy to use. PD patients scored significantly higher than healthy controls, with mixed psychiatric cases showing intermediate values. The Test-Retest procedure gave rise to satisfactory kappa coefficients (0.25 to 1) and the internal consistency was good (Cronbach alpha = 0.86). Factor analysis produced three factors: “crowded and social situations”,“enclosed and open spaces/riding situations” and “simple phobia”.
Dysmorphophohia: clinical features and outcome with behavior therapy
Authors: Gomez-Perez JC , Marks IM , Gutierrez-Fisac JL 
Published: April 2020

SummaryThis case note sludy examined the clinical features and outcome of 30 patients with dysmorphophohia (perhaps (he largest series so far) who had behavioural (exposure) therapy. Method: The clinical Features and treatment outcome on standard contemporary measures were reviewed. Results: All palienls had social avoidance and dysmorphophohia, with abnormal beliefs, often of delusional intensity. For up lo 1-12 months follow-up after exposure, most patients improved in avoidance, work and social adjustment, and in beliefs even if these had initially been delusional. Gains were less than after exposure therapy for non-dysmorphophobic problems such as agoraphobia, specific phobia, social phobia and obsessive-compulsive disorder (OCT)). Conclusions: The importance of separating delusional from delusional dysmorphophohia can be questioned. Exposure therapy appeared useful for dysmorphophohia, but this must be confirmed in a controlled trial and in patients who attend dermatology, plastic surgery and general psychiatric clinics.
Bipolar disorder, cycloid psychosis and schizophrenia: a study using “lifetime” psychopathology ratings, factor analysis and canonical variate analysis
Authors: Brockington IF , Roper A , Buckley M , Copas J , Andrade C , Wigg P , Farmer A , Kaufman C , Hawley R , Meltzer HY 
Published: April 2020

SummaryIn an empirical study on the classification of the psychoses, 302 patients were rated using the Longitudinal Psychopathology Schedule. The data were condensed by factor analysis, which yielded 10 factors - mania and schizomania, depression and suicidal activity, and 6 factors concerned with psychotic symptoms (verbal hallucinosis/passivity, delusion formation, defect symptoms, social decline, cycloid symptomatology and a factor loading depressive auditory hallucinations and visual hallucinations). Provisional diagnostic groups were obtained using DSM III. Discriminant function analyses showed that the only clearly distinct diagnostic group was bipolar disorder, and this was true for various definitions. Canonical variate analyses were performed using 3- and 4-criterion groups. These showed that a group corresponding approximately to cycloid psychosis also met criteria for being a distinct group. The most detailed examination pf the data, using 4-criterion groups and serial reclassification, suggested that the psychoses might fall into 5 groups - bipolar disorder, cycloid psychosis, depression, defect states and schizoaffective depression.
Cortical dysfunction and schizophrenic deficit. Preliminary findings with the delayed reaction paradigm
Authors: Partiot A , Jouvent R , Dubois B , Verin M , Montreuil M , Agid Y , Widlocher D 
Published: April 2020

SummaryPerformance of patients with schizophrenia (n = 15) was compared to that of patients with vascular ischemic lesions of the dorsolateral prefrontal cortex (n= 10) and to age-matched controls (n= 15) in delayed reaction tasks known to be specific markers of the functions of the frontal lobe. The performance of patients with schizophrenia was similar to that of patients with prefrontal lesions in the delayed response task (DR) and the spatial discrimination-reversal task (SD and RV) but not in the delayed alternation task (DA) in which they performed as well as controls. The behavioural profile of responses in delayed reaction tasks for the schizophrenic patients was identical to that of patients with basal ganglia lesions reported in a previous study. These results suggest that in some patients with schizophrenia, a frontal lobe deficit could be indirectly induced by a dysfunction of the basal ganglia. This problem could be due either to the pathological process itself or to the effect of the neuroleptic treatment.
Treatment of drug-resistant chronic schizophrenics with an association of neuroleptics and the calcium antagonist nimodipine
Authors: Brambilla F , Gessa GL , Sciascia A , Latina A , Maggioni M , Perna GP , Bondiolotti GP , Picotti G 
Published: April 2020

SummaryNimodipine was administered at the daily dose of 90 mg po, for 30 days, to ten chronic undifferentiated schizophrenics, eight men and two women, aged 31-35 years, maintained on previously longlasting neuroleptic treatments. In five patients, a placebo period of 15 days preceded the administration of the drug. Monitoring of psychiatric symptomatology by the Brief Psychiatric Rating Scale (BPRS) revealed significant nimodipine-induced improvement. However, the Andreasen Rating Scale for Positive Symptoms (SAPS) showed favourable effects only in the five patients who had not received placebo, while in the others both SAPS and the Andreasen Rating Scale for Negative Symptoms (SANS) showed no significant effect of therapy. The Tardive Dyskinesia Scale revealed no improvements of neurological symptoms after either placebo or drug treatment. Measurement of plasma MHPG concentrations revealed no significant changes induced by either placebo or nimodipine, while HVA plasma levels showed a trend toward decrease, and prolactin a trend toward increase, after nimodipine.
Effects of tianeptine on behavioural and neurochemical responses to immobilization stress
Authors: Curzon G , Datla KP 
Published: April 2020

SummaryThe novel antidepressant drug tianeptine had an antidepressant-like effect on a rat model of depression based on the deficit in open field activity observed on the day after 2 h immobilization. Thus, tianeptine (10 mg/kg ip) given 2 h after the end of the immobilization period led to the deficit being opposed. Similar results were obtained using rats previously given 10 mg/kg of the drug per day for 13 days and a final dose 2 h after the end of immobilization. Other workers have found that tianeptine attenuates stress-induced activation of the hypothalamo-pituitary-adrenal axis. Possible relationships between these findings are discussed together with the paradoxical co-existence of the antidepressant properties of tianeptine with its ability to decrease the availability of 5-HT to receptors.
Effect of tianeptine on neuroendocrine, enzyme and behavioral responses to restraint stress in male rats
Authors: Fontanges R , Mimouni J , de Grieve X , Picard J , Pugeat M , Bange C 
Published: April 2020

SummaryThe effects of the novel antidepressant tianeptine, after acute or chronic administration, were compared in normal and restraint-stressed (30 min or 2 h) Wistar rats. Tianeptine, at the dose of 10 mg/kg, did not exert any effect in non-stressed rats. However, in animals restrained for 30 min, tianeptine reduced the increase of circulating ACTH and β-endorphin levels without modification of corticosterone. Moreover, it antagonized the deficit of vertical exploratory activity in an open field. In rats restrained for 2 hours, a single injection of tianeptine suppressed the stress-induced increase of TAT hepatic activity and moderately attenuated the deficit of activity in the open field. This effect was less marked and not statistically significant after chronic treatment.