bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chirp Signal Denoising Based on Convolution Neural Network
Authors: Guangli Ben , Zheng Xifeng , Wang Yongcheng , Zhang Xin , Zhang Ning 
Published: May 2020

Abstract
Many classical chirp signal processing algorithm may experience distinct performance decrease in noise circumstance. To address the problem, this paper proposes a deep learning based approach to filter noises in time domain. The proposed denoising convolutional neural network (DCNN) is trained to recover the original clean chirps from observation signals with noises. Following denosing, we employ two parameter estimation algorithm to DCNN output. Simulation result show that the proposed DCNN method improves the signal noise ratio (SNR) and parameter estimation accuracy to a great extent compared to the signals without denoising. And DCNN have a strong adaptability of low SNR input scenarios that never trained.
Molecular detection of tick-borne pathogens in cattle from Saudi Arabia
Authors: Alanazi Abdullah D , Alouffi Abdulaziz S , Alshahrani Mohammad Yahya , Alyousif Mohamed S , Abdullah Hend H.A.M. , Allam Ahmad M , Elsawy Bassma S.M. , Abdel-Shafy Sobhy , Alsulami Muslimah 
Published: May 2020

Abstract
Background and aim:

Babesiosis and anaplasmosis are tick-borne diseases that affect the health of cattle and may be also responsible for remarkable economic losses. This study aimed to detect the presence of the causative agents of babesiosis and anaplasmosis among cattle in different provinces in Saudi Arabia and to characterise their species genetically.
Methodology:

A total of 362 blood samples were taken from cattle in four regions (Riyadh, Al-Kharj, Al-Hasa and Al-Qassim) of Saudi Arabia and were molecularly screened by polymerase chain reaction (PCR) of partial 18S rRNA and 23S rRNA genes to detect Babesia and Anaplasma species.
Results

The overall prevalence of both Babesia and Anaplasma in cattle was 2.49% and 5.80%, respectively. Theileria annulata (T. annulata) and Theileria ovis (T. ovis) were found in seven (1.93%) and two (0.55%) of the 362 samples, respectively. Anaplasma ovis (A. ovis) was detected in 21 (5.80%) of 362 samples. Likewise, four of the cattle were found to be co-infected with more than one pathogen (1.10%). All cattle samples tested negative for other species of Babesia, Theileria and Anaplasma.
Conclusion

The presence of T. ovis and A. ovis has been herein reported in Saudi Arabia. The presence of two novel genotypes of T. annulata is also reported in Saudi Arabian cattle. Further molecular surveys on larger numbers of samples from the entire country are needed in order to address correctly the prevalence and geographical distribution of the tick-borne disease.
Study on health-related quality of life and influencing factors of pediatric medical staff during the COVID-19 outbreak
Authors: Huang Feng , Yang Zhe , Wang Yue , Zhang Wei , Lin Yan , Zeng Ling-chao , Jiang Xun , Shang Lei 
Published: May 2020

Abstract
Aims To evaluate the health-related quality of life (HRQoL) status and explore its associated factors in pediatric medical staff during the COVID-19 epidemic so as to guide hospitals and administrators to formulate suitable interventions.Methods A cross-sectional study was conducted to investigate the HRQoL of pediatric medical staff. Univariable and multivariable logistic regression were used to analyze the associated factors.Results A total of 2,997 participants were recruited. Females scored worse than males in terms of emotional functioning (OR = 1.6, 95%CI: 1.2–2.1) and cognitive functioning (OR = 1.4, 95%CI: 1.1–1.8). The respondents aged 30–39 years and 40–49 years scored worse in nearly all domains of HRQoL compared health care professionals under 30 years old. Respondents with high education had lower scores in physical functioning (OR = 1.3, 95%CI: 1.0-1.7) and emotional functioning (OR = 1.5, 95%CI: 1.2–1.9).Compared with doctors, nurses had higher scores in all domains except for summary score and worry. The respondents whose working places had not set up pediatric fever clinics and isolated observation areas independently had better scores in all domains except for worry. The respondents who had ever treated patients with COVID-19 had lower scores in all domains.Conclusions During the COVID-19 outbreak, the HRQoL of pediatric medical staff decreased. The factors associated with HRQoL can be used to develop intervention to improve HRQoL in pediatric medical staff.
Screening prognostic markers for non-small cell lung cancer based on data mining and bioinformatics analysis
Authors: Han Bin , Aman Kaushik Chandra , Wei Dongqing , Zhang Shulin , Meng Minjie 
Published: May 2020

Abstract
Background At present, non-small cell lung cancer has a high morbidity and mortality, and the recurrence and metastasis situation is serious. It is impossible to accurately predict the prognosis of cancer patients clinically. Biomarker is a kind of biomolecule with wide application prospects, and its potential in cancer prognosis is gradually revealed, and it is expected to be applied clinically. Results We integrated four gene expression profiles (GSE19188, GSE19804, GSE101929 and GSE18842) from the GEO database and screened the commonly differentially expressed genes using the GEO2R online tool. We screened 952 commonly differentially expressed genes. Gene ontology analysis showed that CDEGs were mainly enriched in biological processes such as cell adherin, angiogenesis and positive regulation of angiogenesis, and KEGG pathways such as ECM-receptor interaction and cell adherin molecules (CAMs). Up-regulation of G2 and S phase-expressed protein 1(GTSE1) expression is associated with poor prognosis of lung adenocarcinoma(LADE) and lung squamous cell carcinoma(LUSC). Up-regulation of Neuromedin-U(NMU) expression, down-regulation of Proto-oncogene c-Fos(FOS) and Cyclin-dependent kinase inhibitor 1C(CDKN1C) is only associated with poor prognosis of LADE. Conclusions We believe that GTSE1, NMU, FOS, and CDKN1C have potential application value as prognostic markers for lung adenocarcinoma, and are of great significance for lung adeno carcinoma efficacy evaluation and relapse monitoring. At the same time, GTSE1 may also be used as a new target for cancer treatment New ways.
miR-27a-3p attenuates induce autophagy-related cell death by suppressing Inhibitor of growth family 5 in cholangiocarcinoma
Authors: WAN Ming , Zhang Fu-min , Kang Peng-cheng , Jiang Xing-ming , cui yunfu 
Published: May 2020

Abstract
Background MicroRNAs (miRNAs) are abnormally expressed in human tumors, including cholangiocarcinoma (CCA). miR-27a-3p was observed up-regulated in CCA, but its functions in CCA are largely unknown.Methods CCK8 assay, Colony formation assays and Ki-67 staining was employed to detect the cell growth. The autophagy and proliferation relative-protein analyzed by western blot. The immunofluorescence staining was applied to analyze the expression level of LC3 I/II. Tumor xenografts was used to test the role of miR-27a-3p. Luciferase reporter assay, western bolt and qRT-PCR showed the relationship between miR-27a-3p and ING5.Results miR-27a-3p expression was increased in human CCA tissues. Inhibition of miR-27a-3p suppressed the proliferative capacity of CCA cells, silencing of miR-27a-3p dramatically induced cell death and suppressed tumor growth in vivo. The proteins, such as Beclin-1, p62, p21, p-p53, CDK4 and CDK6, were decreased upon miR-27a-3p inhibitor transfection. Western blot assay and immunofluorescence analysis were showed the induced-autophagy after transfecting with miR-27a-3p or inhibitor of growth family 5 (ING5) in RBE. ING5 as a direct miR-27a-3p target in CCA. Co-transfect of miR-27a-3p and ING5 can reverse CCA cell death which induced by miR-27a-3p inhibitor alone.Conclusions miR-27a-3p promotes oncogenesis of CCA by triggering autophagy-related cell death by interacting with ING5 directly.
Methodological aspects of using a wearable eye tracker in differential diagnostics of disorders of consciousness
Authors: Johansson Jan , Franzon Kristina , Godbolt Alison K , Möller Marika 
Published: May 2020

Abstract
Background: The differential diagnosis of disorders of consciousness (DOC) is an important element in prognostication, clinical decision making, and information to families. Diagnosis currently relies to a large extent on clinical assessment using standardized neurobehavioral rating scales. Interpretation of the patient’s responses may be difficult due to cognitive, linguistic, physical, and/or motor impairments associated with the brain injury. Analysis of eye movements using eye tracking technology has been suggested as a potential support in improving diagnostic accuracy.Methods: The aim of the study was to evaluate the feasibility of incorporating eye tracking in a selection of subtests in the Coma Recovery Scale Revised (CRS-R). A secondary aim was to develop a protocol for comparison of the clinician-assessed findings versus the findings based on the eye movement recording. Four adult patients with a persistent disorder of consciousness were assessed with four test items from the CRS-R while eye movements were recorded with a wearable eye tracker.Results: No major adverse reactions were observed suggesting likely patient acceptability. Calibration issues due to oculomotor dysfunction complicated the analysis. However, distinct eye movements were discernible from the recorded data and analysis of these gave findings considered to support clinical assessment. Feasibility and data analysis issues are discussed.Conclusions: Based on patient responses, and the finding that it was possible to record eye movement patterns even without calibration, we conclude that the method is feasible. Further study will help clarify the full potential but the option to record and replay responses in these easily fatigued patients where assessment sessions need to be brief is of great interest. The current hardware and software limitations can be overcome with manual data processing and analysis; however, significant developments in automizing data processing will be required for broader clinical application. Hardware adaptations and the calibration process appear to be important primary targets in this process.
Comparison of intensity modulated radiotherapy treatment plans between 1.5 T MR-Linac and conventional linac
Authors: Ding Shouliang , Li Yongbao , Liu Hongdong , Li Rui , Wang Bin , Zhang Jun , Chen Yan , Huang Xiaoyan 
Published: May 2020

Abstract
Background To assess the dosimetric qualities and usability of planning for 1.5 T MR-Linac based intensity modulated radiotherapy (MRL-IMRT) for various clinical sites in comparison with IMRT plans using a conventional linac.Methods In total of 17 patients with disease sites in the brain, esophagus, lung, rectum and vertebra were re-planned retrospectively for simulated MRL-IMRT using the Elekta Unity dedicated treatment planning system (TPS) Monaco (v5.40.01). Currently, the step-and-shoot (ss) is the only delivery technique for IMRT available on Unity. All patients were treated on an Elekta Versa HD™ with IMRT using the dynamic multileaf collimator (dMLC) technique, and the plans were designed using Monaco v5.11. For comparison, the same dMLC-IMRT plan was recalculated with the same machine and TPS but only changing the technique to step-and-shoot. The dosimetric qualities of the MRL-IMRT plans, to be evaluated by the Dose Volume Histograms (DVH) metrics, Homogeneity Index and Conformity Index, were compared with the clinical plans. The planning usability was measured by the optimization time and the number of Monitor Units (MUs).Results Comparing MRL-IMRT with conventional linac based plans, there were no clinically significant differences between any of the DVH parameters studied for multiple tumor sites. However, MRL-IMRT plans had significantly increased dose to skin and low dose region of normal tissue. Furthermore, MRL-IMRT plans had significantly reduced optimization time by comparing conventional linac based plans. The number of MUs of MRL-IMRT was increased by 23% compared with ss-IMRT, and no difference from dMLC-IMRT.Conclusions Clinically acceptable plans can be achieved with 1.5 T MR-Linac system for multiple tumor sites. The planning efficiency of MRL-IMRT was improved due to the reduced optimization time. However the increase in skin dose and low dose region was also observed in MRL-IMRT plans.
Proton versus photon radiotherapy for primary hepatocellular carcinoma: A propensity-matched analysis
Authors: Cheng Jen-Yu , Liu Chieh-Min , Wang Yu-Ming , Hsu Hsuan-Chih , Huang Eng-Yen , Huang Tzu-Ting , Lee Ching-Hsin , Hung Sheng-Ping , Huang Bing-Shen 
Published: May 2020

Abstract
Background Proton radiotherapy has a dosimetric advantage over photon radiotherapy. Many retrospective studies have shown promising results with proton radiotherapy for treating hepatocellular carcinoma (HCC). However, clinical evidence demonstrating the benefit of protons over photons is still limited. We therefore compared clinical outcomes for the two modalities using medical research databases from our medical foundation.Methods We conducted a propensity score-matched cohort study based on our multi-institution medical organization research database. From January 2007 to January 2018, a total of 413 patients (photon: 349; proton: 64) who were diagnosed with HCC and primarily treated with radiotherapy with curative intent were enrolled. Overall survival (OS) and radiation-induced liver disease (RILD) were assessed. Stratified analysis was also performed to evaluate the heterogeneous effects of the two arms.Results A total of 110 patients (photon: 55; proton: 55) were analyzed in the propensity-matched series. The matched groups were balanced for baseline tumor risk factors. Cox regression analysis revealed a significant survival benefit in the proton group (p = 0.032, HR 0.56, 95 CI 0.33–0.96). The median overall survival in the proton and photon group was not reached and 17.4 months, respectively. The biological equivalent dose for radiotherapy was significantly higher in the proton group than the photon group (median, 96.56 Gray vs. 62.5 Gray, p < 0.001). The risk of RILD was significantly lower in the proton group (11.8% vs. 36%, p = 0.004).Conclusions Proton radiotherapy could deliver a higher radiation dose without increasing the risk of RILD and result in a better overall survival rate for those diagnosed with HCC and treated with radiotherapy with curative intent.
Impact of Functional Disability on Self-Perceived Oral Problems and Oral Care Behaviors among Stroke Survivors: A Cross-Sectional Study
Authors: Wang Yue , Xi CHEN , Cui GUO , Qian-qian ZHANG , Dan-dan SONG , Zheng SUN , Dong YUAN 
Published: May 2020

Abstract
Background:Stroke is a major cause of functional disability, which is in turn correlated with poor oral health.There is a dearth of studies that have investigated self-reported oral health, a measure of how individuals perceive their oral health and unmet treatment needs, in elders after stroke. Therefore, the purpose of this study was to compare self-perceived oral problems and oral care behaviors between stroke survivors with and without functional disability.Methods:Two-hundred and seven stroke survivors were recruited,comprised of 104 participants without functional disability, and 103 with functional disability, based on the modified Rankin Scale. Interviews were conducted to collect data regarding self-perceived oral problems, oral care behaviors, and dental attendance behaviors. Multivariate logistic regression analysis was performed to compare the data between the two groups.Results: After adjusting for sociodemographic variables, the functional disability group was significantly less likely to brush their teeth twice a day (odds ratio [OR], 0.388;95%confidence interval [CI], 0.200-0.751), and both more likely to have a change in teeth cleaning after stroke (OR, 0.155; 95%CI,0.030-0.804), and to need help when cleaning their teeth (OR, 2.701; 95%CI,1.018-7.163). There were no significant differences in self-perceived oral problems or dental attendance behaviors between the two groups.Conclusion: Stroke survivors with functional disability had worse oral care behaviors compared with those without functional disability.
Application of the EANM practical guidance on uncertainty analysis for MRT absorbed dose calculations on clinical cases
Authors: Finocchiaro Domenico , Gear Jonathan I , Fioroni Federica , Flux Glenn D , Murray Iain , Castellani Gastone , Versari Annibale , Iori Mauro , Grassi Elisa 
Published: May 2020

Abstract
Background Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly ignored in clinical routine. However, it is essential for adequate interpretation of the results. Recently, the EANM published a practical guidance on uncertainty analysis for molecular radiotherapy based on the application of the law of propagation of uncertainty. In this study, we investigated the overall uncertainty on a large sample of patient following the EANM guidelines. The aim of this study was to provide an indication of the typical uncertainties that may be expected from performing dosimetry, to determine parameters that have the greatest effect on the accuracy of calculations and to consider the potential improvements that could be made if these effects were reduced. Results Absorbed doses and the relative uncertainties were calculated for a sample of 49 patients and a total of 154 tumours. A wide range of relative dose uncertainty values was observed (14 - 102%). Uncertainties associated to each quantity along the dose calculation chain (i.e. Volume, Recovery Coefficient, Calibration Factor, Activity, Time-Activity Curve Fitting, Cumulated Activity and Absorbed Dose) were estimated. An equation was derived to describe relationship between the uncertainty in the absorbed dose and the volume. The largest source of error was the VOI delineation. By postulating different values of FHWM, the impact of the imaging system spatial resolution on the uncertainties was investigated. Discussion To the best of our knowledge, this is the first analysis of uncertainty in MRT based on a large sample of clinical cases. Wide inter-lesion variability of dose uncertainty was observed. Hence, a proper assessment of the uncertainties associated with the calculations should be considered as a basic scientific standard. A model for a quick estimate of uncertainty without implementing the entire error propagation schema, which may be useful in clinical practice, was presented. Ameliorating spatial resolution may be in future the key factor for accurate absorbed dose assessment.
Prognostic Analysis for Children with Hepatoblastoma with Lung Metastasis: A Single-Center Analysis of 98 Cases
Authors: Hu Huimin , Zhang Weiling , Wang Yizhuo , Zhang Yi , Yi You , Gao Yanan , Chen Liping , Huang Dongsheng 
Published: May 2020

Abstract
Background To analyze the factors affecting prognosis of hepatoblastoma (HB) with lung metastasis in children.Patients and Methods: 98 HB patients with lung metastases admitted to Beijing Tongren Hospital, Capital Medical University were collected and analysed.Results 64 patients had lung metastases at diagnosis (median age, 22.3 months). 34 patients developed lung metastases whilst on treatment (median time, 6.5 months). The time of diagnosis of lung metastasis in patients with HB did not significantly affect survival time or 3-year survival rate (P = 0.37). The survival time and 5-year survival rate of patients with standard treatment was significantly longer than that of without standard treatment (P < 0.001). The survival time and 3-year survival rate of patients with lung metastasis alone or underwent lung metastasectomy was significantly longer than that of patients with extrapulmonary involvement or without lung metastasectomy (P = 0.007, P = 0.099). Lung metastasis accompanied with extrapulmonary involvement was risk factors affecting prognosis (HR = 0.460, 95% CI 0.239–0.888).Conclusions The overall prognosis of HB with lung metastasis in children was poor, and the prognosis of patients with lung metastasis alone was better than those with extrapulmonary involvement. Standardized treatment and resection of lung tumor may prolong the survival of HB patients with lung metastasis.
A Study of Current Medication of Sinupret Drops in Chinese Pediatric Patients
Authors: Shen Jianwen , Yan Jingchao 
Published: May 2020

Abstract
Background Sinupret drops is commonly used as agent dissolving nasal secretions. However, there is no specific regime of Sinupret drops for pediatric patients in China. Therefore, we investigate its current medication in Chinese pediatric patients to provide a recommendation of safe drug use.Methods We collect 6,893 outpatient and emergency pediatric prescriptions of Sinupret drops (age ≤ 15) and focused on the analysis of practical drug dosage and potential risks.Results One-half of the adult dosage was mainly chosen for out-patient children, while the full adult dosage was much more used for pediatric patients in emergency. Its usage in low-age pediatric patients requires further evaluation and surveillance. The pharmaceutical reaction of ethanol in Sinupret drops with some cephalosporins during drug taking will lead to unexpected drug reactions.Conclusion To prevent potential side effects, treatment with Sinupret drops as an adjunct for pediatric patients should draw more attention from their doctors and pharmacists. The age and weight of pediatric patients need to be considered as important parameters for drug administration of Sinupret drops. It is important to strengthen the education of medication, and much attention should be paid to the interval of drug administration.
Spatial Distribution and Use of Agrodiversity in Family Gardens of Tixmucuy, Campeche, Mexico
Authors: José-García Gisela , Candelaria-Martínez Bernardino , BAÑUELOS CAROLINA FLOTA , Bautista-Ortega Jaime , Rosales-Martínez Verónica 
Published: May 2020

Abstract
Background

Family plots or gardens, often referred to as solars, are spaces surrounding a house, that contain a combination of plant and animal species distributed according to the family’s needs. The objective of this work was to identify the structure, use, and agrodiversity of these family plots in the community of Tixmucuy, Campeche, Mexico.
Methods

Six plots of two previously identified types were randomly chosen. A semi-structured questionnaire was applied to family plot managers focusing on family demographic information and plot management. The data was statistically descriptive and the Shannon-Wiener diversity index was applied.
Results

It was observed that families are generally nuclear groups with 3.9 members, with the average age of housewives responsible for the family plots being 45 years of age. The plots have an average extension of 1,155 m2. Three species of birds were observed and were used for food, food-sale, and as pets. 95 plant species were registered and were used for food, wood, or ornamental purposes. In the vertical distribution the herbaceous stratus had the highest number of individuals (29.37), followed by bushy shrubs with 15.2 and arboreal with 7.83 individuals. The importance of the elements and the overall organizational management of the plot by the family determine the horizontal distribution.
Conclusions

The importance of Tixmucuy's family plots lies in the generation of ecosystem services to the family, for which they use plant and animal species in a design that facilitates their management and interaction.