bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing social stressors in a brief motivational interview improve mental health symptoms for Latinx heavy drinkers
Authors: Lee Christina S. , Rosales Robert , Colby Suzanne M. , Martin Rosemarie , Cox Koriann , Rohsenow Damaris J. 
Published: May 2020

AbstractObjectiveDepressive and anxiety symptoms co‐occur with hazardous drinking among Latinxs. This secondary analysis of a clinical trial to reduce hazardous drinking (motivational interviewing adapted to address social stressors [CAMI] vs. motivational interviewing [MI]) examined effects on anxiety/depressive symptoms. Discrimination and acculturation were examined as moderators.MethodsLatinx (n = 296) hazardous drinkers (2+ occasions/month of heavy drinking; 4/5 drinks/occasion, females/males) were randomized to CAMI/MI. Generalized estimating equations analyzed how treatment conditions and interactions were related to depressive and anxiety symptoms after controlling for covariates.ResultsBaseline symptoms (anxiety, depression) exceeded clinical thresholds (Anxiety ≥8, M = 14.62, SD = 13.52; Depression ≥ 12, M = 18.78, SD = 12.57). Cultural adaptation of motivational interviewing (CAMI) showed significantly lower anxiety and depressive symptoms (6/12 months, respectively) than MI. CAMI with high baseline discrimination reported significantly less depression than MI (12 months).ConclusionsExplicitly addressing social stressors may be a beneficial adjunct to treatment for Latinx drinkers.
Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling
Authors: Yu Yi , Ladeiras Diogo , Xiong Yuyan , Boligan Kayluz Frias , Liang Xiujie , von Gunten Stephan , Hunger Robert E. , Ming Xiu‐Fen , Yang Zhihong 
Published: May 2020

AbstractElevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of patients with metastasis than those without metastasis. Silencing Arg‐II in two human melanoma cell lines slowed down the cell growth, while overexpression of native but not a catalytically inactive Arg‐II promoted cell proliferation without affecting cell death. Treatment of cells with arginase inhibitor also reduced melanoma cell number, demonstrating that Arg‐II promotes melanoma cell proliferation dependently of its enzymatic activity. However, results from silencing Arg‐II or overexpressing native or the inactive Arg‐II as well as treatment with arginase inhibitor showed that Arg‐II promotes melanoma metastasis‐related processes, such as melanoma cell migration and adhesion on endothelial cells, independently of its enzymatic activity. Moreover, the treatment of the cells with STAT3 inhibitor suppressed Arg‐II‐promoted melanoma cell migration and adhesion. Furthermore, catalase, but not superoxide dismutase, prevented STAT3 activation as well as increased melanoma cell migration and adhesion induced by overexpressing native or the inactive Arg‐II. Taken together, our study uncovers both activity‐dependent and independent mechanisms of Arg‐II in promoting melanoma progression. While Arg‐II enhances melanoma cell proliferation through polyamine dependently of its enzymatic activity, it promotes metastasis‐related processes, that is, migration and adhesion onto endothelial cell, through mitochondrial H2O2‐STAT3 pathway independently of the enzymatic activity. Suppressing Arg‐II expression rather than inhibiting its enzymatic activity may, therefore, represent a novel strategy for the treatment of melanoma.
BMPER is upregulated in obesity and seems to have a role in pericardial adipose stem cells
Authors: Pérez Laura M. , de Lucas Beatriz , Gálvez Beatriz G. 
Published: May 2020

AbstractPericardial adipose tissue (PAT), a visceral fat depot enveloping the heart, is an active endocrine organ and a source of free fatty acids and inflammatory cytokines. As in other fat adult tissues, PAT contains a population of adipose stem cells; however, whether these cells and/or their environment play a role in physiopathology is unknown. We analyzed several stem cell‐related properties of pericardial adipose stem cells (PSCs) isolated from obese and ex‐obese mice. We also performed RNA‐sequencing to profile the transcriptional landscape of PSCs isolated from the different diet regimens. Finally, we tested whether these alterations impacted on the properties of cardiac mesoangioblasts isolated from the same mice. We found functional differences between PSCs depending on their source: specifically, PSCs from obese PSC (oPSC) and ex‐obese PSC (dPSC) mice showed alterations in apoptosis and migratory capacity when compared with lean, control PSCs, with increased apoptosis in oPSCs and blunted migratory capacity in oPSCs and dPSCs. This was accompanied by different gene expression profiles across the cell types, where we identified some genes altered in obese conditions, such as BMP endothelial cell precursor‐derived regulator (BMPER), an important regulator of BMP‐related signaling pathways for endothelial cell function. The importance of BMPER in PSCs was confirmed by loss‐ and gain‐of‐function studies. Finally, we found an altered production of BMPER and some important chemokines in cardiac mesoangioblasts in obese conditions. Our findings point to BMPER as a potential new regulator of PSC function and suggest that its dysregulation could be associated with obesity and may impact on cardiac cells.
Talazoparib Exposure‐Efficacy Analysis in Patients With Advanced Breast Cancer and Germline BRCA1/2 Mutations in the EMBRACA Trial
Authors: Yu Yanke , Elmeliegy Mohamed , Litton Jennifer K. , Tudor Iulia Cristina , Czibere Akos , Zheng Jenny , Wang Diane D. 
Published: May 2020

AbstractIn the phase 3 EMBRACA trial, treatment with the poly(ADP‐ribose) polymerase inhibitor, talazoparib, led to significantly improved progression‐free survival (PFS) compared with chemotherapy (hazard ratio, 0.54; 95% confidence interval, 0.41‐0.71; P < .0001). We conducted an exposure‐efficacy analysis using EMBRACA data from 285 patients who were treated with talazoparib and had available pharmacokinetic parameters to evaluate the effect of talazoparib exposure (time‐varying average talazoparib concentration [Cavg,t]) and other baseline variables on PFS. Graphical examination of the relationship between Cavg,t and PFS and a Cox proportional model were used. Exposure‐response analyses showed that higher talazoparib exposure, absence of visceral disease, lower baseline lactate dehydrogenase levels, and disease‐free interval >12 months were independent covariates associated with longer PFS. The association of talazoparib exposure with PFS (higher exposure, longer PFS) suggests the recommended starting dose of 1 mg once daily (the maximum tolerated dose) is appropriate.
Estimation of the basic reproduction number, average incubation time, asymptomatic infection rate, and case fatality rate for COVID‐19: Meta‐analysis and sensitivity analysis
Authors: He Wenqing , Yi Grace Y. , Zhu Yayuan 
Published: May 2020

AbstractThe coronavirus disease‐2019 (COVID‐19) has been found to be caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). However, comprehensive knowledge of COVID‐19 remains incomplete and many important features are still unknown. This manuscript conducts a meta‐analysis and a sensitivity study to answer the questions: What is the basic reproduction number? How long is the incubation time of the disease on average? What portion of infections are asymptomatic? And ultimately, what is the case fatality rate? Our studies estimate the basic reproduction number to be 3.15 with the 95% CI (2.41‐3.90), the average incubation time to be 5.08 days with the 95% CI (4.77‐5.39) (in day), the asymptomatic infection rate to be 46% with the 95% CI (18.48%‐73.60%), and the case fatality rate to be 2.72% with 95% CI (1.29%‐4.16%) where asymptomatic infections are accounted for.
Early risk factors of the exacerbation of coronavirus disease 2019 pneumonia
Authors: Wang Chang‐Zheng , Hu Shun‐Lin , Wang Lin , Li Min , Li Huan‐Tian 
Published: May 2020

AbstractThe purpose of this study was to investigate the early risk factors for the exacerbation of coronavirus disease 2019 (COVID‐19) pneumonia. Restrospective analysis of clinical data of 85 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), including gender, age, comorbidities, symptoms, blood routine, clotting profile, biochemical examination, albumin, myocardial enzyme profile, inflammatory markers, and chest computed tomography (CT). All laboratory examinations were measured within first 24 hours after admission, and chest CT was performed before admission. A total of 56 (65.9%) patients had a history of exposure to the Huanan seafood market in Wuhan. Fever and dry cough accounted for the highest percentage of all symptoms. Male COVID‐2019 patients were more likely to develop severe pneumonia. Patients with severe and critical conditions are older and have higher rates of hypertension (P = .003) and coronary heart disease (P = .017). All severe and critical patients infected with SARS‐CoV‐2 showed bilateral lung involvement and have more multiple lobes involvement than common patients (P < .001). Severe and critical patients showed higher white blood cell count (P = .006), neutrophil (NEU) count (P = .001), NEU% (P = .002), procalcitonin (P = .011), C‐reactive protein (P = .003), prothrombin time (P = .035), D‐dimer (P = .025), aspartate aminotransferase (P = .006), and lower lymphocyte (LYM) count (P = .019), LYM% (P = .001), albumin (P < .001). Logistic regression analysis showed that NEU count is an independent risk factor for deterioration, with the threshold of 6.5 × 109·L−1. We concluded that the laboratory independent risk factor for the progression of COVID‐19 pneumonia is NEU count. In addition, COVID‐19 patients with bilateral lung involvement or multiple lobes involvement should be taken seriously and actively treated to prevent deterioration of the disease.
Serum KL‐6 concentrations as a novel biomarker of severe COVID‐19
Authors: d'Alessandro Miriana , Cameli Paolo , Refini Rosa Metella , Bergantini Laura , Alonzi Valerio , Lanzarone Nicola , Bennett David , Rana Giuseppe Domenico , Montagnani Francesca , Scolletta Sabino , Franchi Federico , Frediani Bruno , Valente Serafina , Mazzei Maria Antonietta , Bonella Francesco , Bargagli Elena 
Published: May 2020

AbstractSevere acute respiratory syndrome coronavirus 2–induced direct cytopathic effects against type I and II pneumocytes mediate lung damage. Krebs von den Lungen‐6 (KL‐6) is mainly produced by damaged or regenerating alveolar type II pneumocytes. This preliminary study analyzed serum concentrations of KL‐6 in patients with coronavirus disease (COVID‐19) to verify its potential as a prognostic biomarker of severity. Twenty‐two patients (median age [interquartile range] 63 [59‐68] years, 16 males) with COVID‐19 were enrolled prospectively. Patients were divided into mild‐moderate and severe groups, according to respiratory impairment and clinical management. KL‐6 serum concentrations and lymphocyte subset were obtained. Peripheral natural killer (NK) cells/µL were significantly higher in nonsevere patients than in the severe group (P = .0449) and the best cut‐off value was 119 cells/µL. KL‐6 serum concentrations were significantly higher in severe patients than the nonsevere group (P = .0118). Receiver operating characteristic analysis distinguished severe and nonsevere patients according to KL‐6 serum levels and the best cut‐off value was 406.5 U/mL. NK cell analysis and assay of KL‐6 in serum can help identify severe COVID‐19 patients. Increased KL‐6 serum concentrations were observed in patients with severe pulmonary involvement, revealing a prognostic value and supporting the potential usefulness of KL‐6 measurement to evaluate COVID‐19 patients' prognosis.
Dietary supplementation with citrus extract alters the plasma parameters, circulating amino acid profiles and gene expression of small intestinal nutrient transporters in Chinese yellow‐feathered broilers
Authors: Yu Miao , Li Zhenming , Wang Gang , Cui Yiyan , Rong Ting , Tian Zhimei , Liu Zhichang , Li Jiazhou , Chen Weidong , Ma Xianyong 
Published: May 2020

AbstractBACKGROUNDThis study evaluated the effects of citrus extract (CE) on growth performance, plasma amino acid (AA) profiles, intestinal development and small intestine AA and peptide transporter expression levels in broilers. A total of 540 one‐day‐old yellow‐feathered broilers were fed a basal diet without any antibiotic (control group), or a basal diet containing 10 mg kg−1zinc bacitracin (antibiotic group), or a basal diet supplemented with 10 mg kg−1CE (CE group). After 63 days of feeding, two broilers per pen were slaughtered to collect tissues for further analysis.RESULTSResults showed that CE increased (P < 0.05) the final body weight and average daily gain from day 1 to 63, and decreased (P < 0.05) the feed/gain ratio from day 1 to 63. Dietary CE supplementation increased (P < 0.05) plasma total protein, albumin and glucose concentration, and decreased (P < 0.05) urea concentration. CE supplementation increased (P < 0.05) the villus height in the ileum and the villus height/crypt depth in the jejunum and ileum, but decreased (P < 0.05) the crypt depth in the jejunum and ileum. CE supplementation increased (P < 0.05) most plasma essential AA concentrations. Additionally, CE supplementation upregulated (P < 0.05) ASCT1, b0,+AT, B0AT1, EAAT3, rBAT, y+LAT2 and PepT1 expression in the jejunum, and b0,+AT, EAAT3, rBAT, y+LAT2, CAT1 and PepT1 in the ileum.CONCLUSIONSCollectively, our results indicated that CE supplementation promotes intestinal physiological absorption of AAs by upregulating gene expression of small intestinal key AA and peptide transporters, thereby enhancing the growth performance of broilers. © 2020 Society of Chemical Industry
Importance of resection for locoregional disease control in Masaoka stage IVA thymic neoplasms
Authors: Corsini Erin M. , Mitchell Kyle G. , Hofstetter Wayne L. , Mehran Reza J. , Roth Jack A. , Sepesi Boris , Swisher Stephen G. , Vaporciyan Ara A. , Walsh Garrett L. , Antonoff Mara B. , Rice David C. 
Published: May 2020

AbstractBackground and ObjectivesIt is unclear if a specific strategy for simultaneous treatment of primary thymic neoplasms and pleural metastases confers benefit for Masaoka stage IVA disease. We reviewed our experience with thymic neoplasms with concurrent pleural metastases to identify factors influencing outcomes.MethodsRecords of patients who presented with stage IVA thymic neoplasms from 2000 to 2018 were assessed. Multivariate Cox proportional hazards analyses were completed to determine predictors of progression‐free and overall survival.ResultsForty‐eight patients were identified, including 34 (71%) who underwent surgery. Median overall and progression‐free survival were 123 and 21 months, respectively. The extent of resection varied, and was most commonly thymectomy plus partial pleurectomy (22, 65%). Median progression‐free survival for patients who underwent surgical resection versus those who had not was 24 versus 12 months (P = .018). Following surgical resection, mediastinal recurrence was uncommon (2, 6%, vs 7, 50% nonoperatively). Five‐year survival rates in these groups were suggestive of possible benefit to surgery (87% vs 68%).ConclusionsThymic neoplasms with pleural dissemination represents a treatment challenge. As part of a multidisciplinary approach, surgery appears to be associated with more favorable long‐term results, although selection bias may account for some of the survival differences observed.
Outcomes after completion thyroidectomy versus total thyroidectomy for differentiated thyroid cancer: A single‐center experience
Authors: Dedhia Priya H. , Stoeckl Elizabeth M. , McDow Alexandria D. , Pitt Susan C. , Schneider David F. , Sippel Rebecca S. , Long Kristin L. 
Published: May 2020

AbstractBackgroundThyroid cancer diagnoses are often discovered after diagnostic thyroid lobectomy. Completion thyroidectomy (CT) may be indicated for intermediate or high‐risk tumors to facilitate surveillance and/or adjuvant treatment. The completeness of thyroid resection and the safety of CT compared to total thyroidectomy (TT) is unclear. We assessed outcomes after TT or CT to determine completeness of resection and risk of complications.MethodsPatients undergoing TT or CT between 2000 and 2018 were retrospectively reviewed. Pathology, unstimulated thyroglobulin (uTg), parathyroid hormone (PTH), rates of hematoma, and recurrent laryngeal nerve (RLN) injury were compared.ResultsDifferentiated thyroid cancer (DTC) was identified in 954 patients undergoing TT and 142 patients undergoing CT. Postoperative uTg at 6 months was not different between TT and CT, 0.2 vs 0.2 ng/mL, P = .37.Transient hypoparathyroidism with immediate postoperative PTH less than 10 was more common after TT, 14.3 vs 6.0% (P = .009). No differences were noted regarding postoperative hematoma, transient RLN injury, permanent hypoparathyroidism, and permanent RLN injury.ConclusionsIf CT is required for DTC, a complete resection, as assessed by postoperative uTg, can be achieved. Furthermore, CT is significantly less likely to result in transient hypoparathyroidism and poses no additional risk of RLN injury, hematoma, or permanent hypoparathyroidism.
Formulation and characterization of cookies prepared from the composite flour of germinated kidney bean, chickpea, and wheat
Authors: Sibian Mandeep Singh , Riar Charanjit Singh 
Published: May 2020

AbstractThe objective of this study was to optimize the formulation of cookies from the composite flour of germinated kidney bean, chickpea, and wheat using response surface methodology (RSM). Snap force, spread ratio, and overall acceptability served as responses for the optimization of cookie formulation. Optimization and validation of central composite rotatable design (CCRD) of RSM concluded the feasibility of using 19.11 g of germinated kidney bean flour, 31.19 g of germinated chickpea flour, and 50.00 g of germinated wheat flour, per 100 g of flour composition for cookie preparation. Characterization of the novel formulated product was done by analyzing various attributes of flour and cookies. Optimized composite flour formulation (OCFF) exhibited appropriate functional and pasting characteristics required for cookie preparation. Optimized composite flour cookies (OCFCs) had a higher amount of protein (12.32 ± 0.11), fats (22.57 ± 0.23), and crude fiber (5.64 ± 0.02) content as compared with ungerminated wheat flour cookies (UWFCs). in vitro digestibility (carbohydrate and protein) was significantly higher in OCFCs owing to the utilization of geminated grain's flour. Amino acid content of germinated grains enhanced the total essential amino acids in OCFCs. Shelf life of the formulated product was acceptable for up to 90 days when stored at 25°C in aluminum‐laminated sealed bags.
Performance of hydrostatic and non‐hydrostatic dynamical cores in RegCM4.6 for Indian summer monsoon simulation
Authors: Maurya R. K. S. , Mohanty M. R. , Sinha P. , Mohanty U. C. 
Published: May 2020

AbstractThe efficacy of regional climate model RegCM4.6 using hydrostatic core resolutions at 36km (HY36) and 12km (HY12) and a non‐hydrostatic core resolution at 12km (NH12) is investigated by simulating the normal, excess and deficit monsoon seasons. The ERA‐Interim reanalysis data are used to drive the model and the India Meteorological Department (IMD) and modern‐era retrospective analysis for research and applications (MERRA) rainfall data are used for precipitation verification. The heavy rainfall regions are well simulated in the high‐ compared with the coarse‐resolution simulations, with the maximum in the NH12. The non‐hydrostatic dynamics amalgamate the vertical acceleration with the orographic uplifting that causes more precipitation over hilly regions than that of the hydrostatic core. On the other hand, the lesser precipitation over northwest India is better portrayed in the HY12 than in the other two. Over central India, the HY36 performs better followed by the NH12; and the contrasting precipitation features are also well depicted in the HY36 and NH12. This is probably because of the better representation of large‐scale monsoon features, such as a monsoon trough in the HY36 and local‐scale convective activities in the NH12. Daily rainfall analysis also shows that the high‐resolution model is capable of capturing the active and break phases during the El Niño and La Niña seasons. The non‐hydrostatic model possesses good correlation co‐efficients >0.5 over the hydrostatic model with co‐efficients of 0.35. The analysis of upper air circulations and the derived parameters, including statistical tests, confirm that the RegCM4.6 with non‐hydrostatics is useful for orographic regions, hydrostatic at a coarse resolution and non‐hydrostatic at a finer resolution and could be suitable for plain regions.
QSPR Modeling of Liquid‐liquid Equilibria in Two‐phase Systems of Water and Ionic Liquid
Authors: Klimenko Kyrylo Oleksandrovych , Inês João Miguel , Esperança José Manuel Silva Simões , Rebelo Luís Paulo Nieto , Aires‐de‐Sousa João , Carrera Gonçalo Valente Silva Mariño 
Published: May 2020

AbstractThe increasing application of new ionic liquids (IL) creates the need of liquid‐liquid equilibria data for both miscible and quasi‐immiscible systems. In this study, equilibrium concentrations at different temperatures for ionic liquid+water two‐phase systems were modeled using a Quantitative‐Structure‐Property Relationship (QSPR) method. Data on equilibrium concentrations were taken from the ILThermo Ionic Liquids database, curated and used to make models that predict the weight fraction of water in ionic liquid rich phase and ionic liquid in the aqueous phase as two separate properties. The major modeling challenge stems from the fact that each single IL is characterized by several data points, since equilibrium concentrations are temperature dependent. Thus, new approaches for the detection of potential data point outliers, testing set selection, and quality prediction have been developed. Training set comprised equilibrium concentration data for 67 and 68 ILs in case of water in IL and IL in water modeling, respectively. SiRMS, MOLMAPS, Rcdk and Chemaxon descriptors were used to build Random Forest models for both properties. Models were subjected to the Y‐scrambling test for robustness assessment. The best models have also been validated using an external test set that is not part of the ILThermo database. A two‐phase equilibrium diagram for one of the external test set IL is presented for better visualization of the results and potential derivation of tie lines.