bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of the pineal gland hormone melatonin in maintaining the health of women of reproductive age (a review)
Authors: Danilova M. V. , Usoltseva E. N. 
Published: January 2020

Introduction. Maintaining women's reproductive health is an important task that requires safe approaches based on the pathogenesis. More and more studies address the role of the pineal gland (epiphysis) hormone melatonin (МТ) in the functioning of the reproductive system, as well as the impact of МТ deficiency on the women’s health.Aim: to analyze and summarize the available literature about the role of the pineal gland hormone МТ in the pathogenesis of gynecological diseases in women of reproductive age (infertility, endometriosis, polycystic ovary syndrome, premenstrual syndrome), and also about the impact of МТ deficiency on the health of women working night shifts.Materials and methods. The relevant publications were searched in domestic (eLibrary, CyberLeninka.ru) and international (Pubmed, Cochrane Library) databases; we looked up the materials published in the recent 7 years. In our search, we prioritized the free access to full text articles. The selection of sources was limited to the period from 2012 to 2019.Results. МТ is involved in the development of follicles by causing the oocytes maturation, promoting the development of embryos, inhibiting the synthesis of steroids in the ovaries and, therefore, reducing the level of steroids in the blood. MT delays ovarian aging through a variety of mechanisms, including the antioxidant action, the maintenance of the due length of the telomere, the upregulated expression of the aging-related SIRT genes, and also the regulation of the ribosome functioning. As MT protects germ cells from oxidative stress, it is essential for normal ovulation, fertilization and further development of the embryo; this hormone has an impact on the duration of the woman's fertility and the onset of menopause. MT has a potential therapeutic effect on endometriosis. The oncostatic role of MT in hormone-dependent breast tumors has been described. Disruption of normal MT production during night shifts is associated with the risk of developing breast cancer in shift workers. MT deficiency leads to circadian desynchronosis and may cause both somatic disorders (metabolic syndrome, obesity, oncopathology) and neuroendocrine dysregulation of the female reproductive system.Conclusion. The variety of physiological functions of the pineal gland hormone MT emphasizes the pathogenetic role of its deficiency in many gynecological and somatic diseases. Of particular relevance is the increased risk of cardiovascular disorders, the development of metabolic syndrome and breast cancer in women who work night shifts. Therefore, it is important both to maintain normal endogenous level of MT and also use its therapeutic potential to maintain the health of women of reproductive age.
Curso de Extensão Semipresencial em Agroecologia: Inclusão Cidadã de Jovens do Campo pela Educação a Distância nos Territórios Maranhenses
Authors: Santos Itaan Pastor , Gonçalves Ricardo Costa 
Published: January 2020

O presente artigo se propõe apresentar a concepção, finalidade, funcionamento e metodologia do Curso de Extensão Semipresencial em Agroecologia promovido pelo Núcleo de Extensão e Desenvolvimento da Universidade Estadual do Maranhão. O curso tem como objetivo formar jovens rurais de quatro territórios maranhenses para que possam desenvolver atividades produtivas na perspectiva agroecológica em suas comunidades de modo a garantir a segurança alimentar das suas famílias e manter a sustentabilidade ambiental dessas áreas. A metodologia inclui videoaulas, tempo de estudo na comunidade e práticas ministradas por técnicos do Núcleo. Mesmo com todas as dificuldades impostas pela falta de infraestrutura nos municípios e apoio das prefeituras municipais, o curso já apresenta resultados tanto relacionados ao processo de conscientização da importância do uso da Agroecologia como modelo de produção quanto na implantação de sistemas que geram alimentação e renda para as famílias dos jovens participantes do projeto.
Palavras-chave: Educação a distância. Agroecologia. Territórios rurais. Juventude rural.
O Modelo EaD e Estilos de Aprendizagem: Um Estudo de Caso no Colégio Pedro II
Authors: Silva Fabiana Adão , Freitas Victor Gonçalves Gloria , Martins Bianca Maria Rego , Cunha Pedro Almeida , Goodman Thomas Andrew Holmes 
Published: January 2020

Com o intuito de melhorar a eficácia do processo de ensino-aprendizagem, pesquisadores em educação têm identificado diferentes estilos de aprendizagem e como as pessoas processam novos conhecimentos, de acordo com as percepções de cada um. Dentre os estilos de aprendizagem, dialogamos neste estudo com canais da expressão humana chamados de modalidades, identificados por três estilos de aprendizagem: visual, auditivo e cinestésico, sintetizados pela sigla VAC. O presente trabalho apresenta uma pesquisa aplicada no Colégio Pedro II no Rio de Janeiro, mais especificamente no curso de Especialização no Ensino de Artes Visuais na modalidade a distância, com o propósito de refletir sobre a diversidade de aprendizagem dos alunos na Educação a Distância e sua relação com o material didático oferecido. Este estudo partirá da hipótese de que se os modelos de ensino e materiais didáticos na EaD não contemplam os diferentes estilos de aprendizagem, pode ocorrer alguma defasagem e desinteresse na assimilação do conteúdo. Para explorar os estilos de aprendizagem, será proporcionada, através desta pesquisa, maior familiaridade do problema, com base no experimento de identificar o perfil dos alunos pelo método VAC.
Palavras-chave: Educação a distância. Estilos de aprendizagem. VAC. tecnologia.
Sprawiedliwość jako bezstronność: problem wartości w perspektywie glottodydaktycznej
Authors: Sadownik Barbara 
Published: January 2020

Niniejszy artykuł poświęcony jest wieloaspektowej problematyce wartości i wartościowania moralnego, przy czym w sposób szczególny koncentruje się wokół sprawiedliwości jako bezstronności, tj. takiej właściwości postępowania nauczyciela, która zasługuje na szczególne wyróżnienie. Podkreślona została unikatowość polskiej koncepcji glottodydaktyki, która buduje swe podstawy teoretyczne na faktach antropologicznych. Autorka wychodzi z założenia, że stała niezmienna natura ludzka stanowi podstawę wyznaczającą obiektywny i niezmienny porządek wartości. Wnikliwej analizie zostały poddane dotychczasowe próby poszukiwania uniwersalnej klasyfikacji i hierarchizacji wartości, jak też wysiłek ukierunkowany na uchwycenie relacji występujących między hierarchią wartości a strukturą natury ludzkiej. Wskazana została potrzeba aktualizacji problemu wartości, zwłaszcza adekwatnego scharakteryzowania poczucia sprawiedliwości i oparcia zdroworozsądkowych ujęć zasad sprawiedliwości na podstawach teoretycznych. W tym celu została dokonana rekonstrukcja podstawowych założeń i twierdzeń Teorii sprawiedliwości Johna Rawlsa, która stanowi wielowymiarową deskrypcję i eksplikację ludzkiego zmysłu moralnego. Ponadto zostały przedstawione daleko idące praktyczne implikacje koncepcji sprawiedliwości jako bezstronności dla określenia zasad działania sprawiedliwego nauczyciela w procesie (glotto)dydaktycznym.
FILM TRANSFORMATIONS FROM ANALOG TO DIGITAL: A CASE STUDY OF FILM RESTORATION IN INDONESIA
Authors: Briandana Rizki , Aisyah Dwityas Nindyta , Joko Priyono Bambang , Audinna Salsabilla 
Published: January 2020

Purpose of the study: The purpose of this research is to analyze how the innovations are done in the film restoration process because each celluloid film has a different character.
Methodology: Methodology in this research is a case study by using data collecting technique of interview and observation.
Main Findings: The research results obtained that the film restoration process is able to meet the standardization of broadcast-quality on television.
Applications of this study: Primary data in the research comes from an interview with six informants. Each of the informants is a practitioner who is engaged in film restoration, from the production manager, head of the restoration, head of the film laboratory, film scanning, and film editor.
Novelty/Originality of this study: The digitalization is an innovation that has to be developed to save films and documentaries with high historical values so that each generation can learn and know the history of events that had occurred in the past.
IN THE TWENTIETH CENTURY, FOUCAULDIAN ASCENDANCY ON THE HISTORICAL AND CULTURAL MATERIALISM MOVEMENTS
Authors: Deivasigamani T. , Dinakaran P. , Shanmugasundaram C. , Premchandar P. , Glory A. 
Published: January 2020

Purpose of the study: This paper analyses the prominent movements that have been significantly influenced by Foucauldian conceptions particularly power relations and knowledge. This paper focuses on two critical movements namely Historical movement and Cultural materialism movement.
Methodology: This is a review paper and largely based on secondary data analysis. Foucault's ideas influenced some movements such as New Historicism and Cultural Materialism. I will discuss how Foucault was inspired and influenced by some thinkers like Nietzsche. So, the present appears to be the issue to be studied historically. This point of view led to the rise of some movements, which are focusing on present issues and problems.
Main Findings: The current study shows firstly that the German philosopher Michel Foucault has a great influence on many literary movements particular the new one such as Cultural materialism and new Historicism and so on. Secondly, it appears Foucault's inspiration by some thinkers and philosophers like Louis Althusser, Nietzsche, and Machiavelli.
Applications of this study: Foucault has an impact on the other movements and thinkers in which many types of research in contemporary age deal with issues that Foucault involves in his works, such as social, political and economic issues. One of the materials that Foucault focusing it, the significance of past and relate to the present.
Novelty/Originality of this study: The reader can feel the obvious influence of Michel's writings through a variety of features of Althusser and Nietzsche particularly Foucault regarded Nietzsche's idea as the departure point for his power theory.
Using SWOT analysis to substantiate marketing strategies for balneo-tourism
Authors: Neacsu Monica Nicoleta , Platon Otilia Elena 
Published: January 2020

Given its social, economic and environmental impact, together with its history and tradition, balneo-tourism counts among the most important forms of tourism practiced in Romania, thus being useful to constantly identify, analyse and develop ways of supporting its positive evolution on a long term. The purpose of this article is to present, along with theoretical references regarding the importance of substantiating marketing strategies in balneo-tourism marketing planning, the results of a SWOT analysis developed in order to create better-adapted marketing strategies for balneo-tourism in Romania. The SWOT analysis is based on a qualitative research, conducted among several Romanian experts directly involved in the field of balneo-tourism. Therefore, the results obtained and the conclusions drawn can be used to substantiate marketing strategies for balneo-tourism in Romania, emphasising the main strengths and opportunities, such as the various, high quality, natural resources and the positive dynamic of the tourism market, and improving or limiting the impact of the weaknesses and threats, such as the insufficient specialised human resources and the lack of financial resources. The paper presents a series of recommendations regarding the addressed matter and offers a comprehensive point of view upon relevant aspects that should be dealt with in order to support more efficiently the Romanian balneo-tourism evolution.
Keywords: Tourism, SWOT analysis, marketing strategy, qualitative research.
Anti-eczema Mechanism of Action of Nigella sativa for Atopic Dermatitis: Computer-aided Prediction and Pathway Analysis Based on Protein-chemical Interaction Networks
Authors: Widyaswari Meidyta Sinantryana , Noventi Iis , Supriyana Herdiantri 
Published: January 2020

Introduction: Black cumin (Nigella sativa) is widely used to treat various diseases. It is also believed to relief skin conditions accompanied by itching symptom, such as atopic dermatitis (AD) or eczema. However, the anti-eczema mechanism of action is still unclear. The aims of this syudy was to identify anti-eczema mechanism of action of N. sativa for AD using computer aided prediction and pathway analysis based on protein-chemical networks. Methods: We utilized dataset consisting chemical compounds of N. sativa from KNApSAcK. It is a comprehensive species-metabolite relationship database. Using canonical SMILES strings that encode molecular structures of each compound, we predicted the probabilities of activity (Pa) for anti-eczema effect based on PASS algorithms. The compounds with Pa >0.7 were included for pathway analysis based on protein-chemical interaction networks in STITCH database. We selected interactomes built by experimental data, gene co-expression, closest gene position, fusion, co-occurence, computational prediction, and other secondary data. Results: Thirty-five active compounds of N. sativa have been utilized and 19 of them have potential anti-eczema effects. Oleic acid and lauric acid were predicted with Pa-value of 0.947 and 0.920 for anti-eczema effect, respectively. However, only lauric acid was confirmed having a plausible mechanism of action via LY96-TLR4- PIK3R1 pathway for lipopolysaccharide receptor activity (false discovery rate [FDR] = 0.0243) and low-density lipoprotein particle receptor binding (FDR = 0.0118). Conclusion: Lauric acid in N. sativa has potential antieczema effect to prevent relaps in AD patients by controlling opportunistic bacterial infection that aggravates itching symptom in this condition.
Application of kudzu flowers to reduce beer toxicity
Authors: Meledina T. V. , Davydenko S. G. , Aravina K. I. , Golovinskaia O. V. , Amirova E. R. , Novikova I. V. 
Published: January 2020

Over the past 30 years, alarming growth in alcohol consumption has been observed in many countries around the world, which is reflected in an increase in alcohol production. For example, in China, beer production has increased 2.27 times over the past "*"18 years. The annual per capita consumption of alcoholic beverages in China increased from 4.9 liters in 2003–2005 to 7.2 liters in 2016. In Europe, various chemicals are used to treat alcohol dependence. Eastern medicine for the treatment of alcoholism uses extracts of the plant Pueraria Lobata Flower (kudzu). The principle of action of kudzu is based on a decrease in the activity of enzymes that break down ethanol in the human body, as a result of which the metabolism of ethanol in the liver is optimized. At the same time, the toxic effects of alcohol are reduced. With a decrease in toxicity while enhancing the effect of intoxication, the need for alcohol decreases. The purpose of these studies was to study the effect of the extract from kudzu flowers on reducing the toxicity of ethanol and to identify the possibility of using the extract in brewing. Determination of the concentration of alcohol, at which there is a decrease in its toxicity with the addition of the extract, was carried out using a test with Saccharomyces cerevisiae yeast. In the course of studies, a positive effect of the extract from kudzu flowers on the resistance of yeast to ethanol stress and, as a consequence, on their physiological activity was established. In addition, it was concluded that it is advisable to add the extract from kudzu flowers to beer after the filtration process.
PRIMARY AND SECONDARY SOMATIC EMBRYOGENESIS OF CACAO: THE EFFECT OF EXPLANT TYPES AND PLANT GROWTH REGULATORS
Authors: Ajijah Nur , Hartati Rr Sri 
Published: January 2020

<p class="abstrakinggris">The success of cacao somatic embryogenesis is affected by many factors, including the basal salt medium, the genotype, the explant type, and the concentration and composition of plant growth regulators (PGRs). The study aimed to evaluate the effects of PGRs composition on the primary somatic embryo (PSE) response and the effect of explant type and PGRs composition used in inducing PSE on the secondary somatic embryogenesis (SSE) response. PSEs were induced from basal petal and staminoid explants of MCC 01 and MCC 02 clones on DKW medium containing 2,4-D 2 mg l<sup>-1 </sup>+ kinetin 0.5 mg l<sup>-1</sup> or 2,4-D 2 mg l<sup>-1</sup> + kinetin 0.125 – 0.250 mg l<sup>-1</sup> + thidiazuron (TDZ) 2.5 – 5 µg l<sup>-1</sup> or 2,4-D 2 mg l<sup>-1</sup> + TDZ 10 µg l<sup>-1</sup>. Genotype, explant type, and PGR composition dependently affected PSE response. The best PSE response was obtained from staminoid explant of MCC 02 clone on medium containing 2,4-D 2 mg l<sup>-1</sup> + kinetin 0.5 mg l<sup>-1</sup> (20%, 9 embryos). The explant type and PGR composition used in inducing PSEs affect the SSE response. The highest SSE response of MCC 01 clone was obtained from petal explant with medium containing 2,4-D 2 mg l<sup>-1</sup> + kinetin 0.5 mg l<sup>-1</sup>. The formation of SSEs could increase the multiplication rate of MCC 01 clone by 7 times.</p>
Feto-Maternal Outcomes Of Hypertensive Disorders Of Pregnancy In Yekatit-12 Teaching Hospital, Addis Ababa, Ethiopia: A Retrospective Study
Authors: Mengistu Mekoya Dabulo , Kuma Tilahun 
Published: January 2020

Abstract
Background In resource poor countries, hypertensive disorders of pregnancy are common and form one of the deadly triad, along with hemorrhage and infection, which contribute greatly to maternal and fetal jeopardy. Methods The aim of this study was to assess the prevalence of hypertensive disorders of pregnancy, and determine the effects of hypertensive disorders of pregnancy on the feto-maternal outcomes. It was a descriptive, cross-sectional, retrospective study on 615 women who attended delivery at Yekatit-12 Teaching Hospital from July 2017 - Jan 2018. Data was analyzed using SPSS version 20 software. Descriptive statistics were used to calculate rates. Chi-square statistics were used to estimate the associations among selected predictor variables. A p-value < 0.05 was taken as statistically significant. Results Out of the 615 study population, the prevalence of hypertensive disorders of pregnancy was found to be 25.4%, of which the majority (54.5%) was severe pre-eclampsia. Eclampsia accounted for 2.6%, and superimposed pre-eclampsia was 2.6%. The rate of severe pre-eclampsia with HELLP syndrome was 7.1% of all mothers with the hypertensive disorders. The majority of mothers with hypertensive disorders (59.6%) had age range of 25-34 years. About 46% of mothers required interventions to terminate the pregnancy either by cesarean section (42.3%) or instrumental deliveries (3.7%). The rate of preterm, low birth weight, and low Apgar at 1st and 5thminutes accounted for 30%, 25%, 24.4% and 16.7% of neonates born to mothers with hypertensive disorders, respectively. Over 19% of neonates required resuscitation and 11.5% NICU referral. The rate of still birth was 2.6%. Conclusion The prevalence of hypertensive disorders of pregnancy is high in the study area and complicates maternal and fetal outcomes of the pregnancy. To deter its detrimental effects both on fetal and maternal outcomes of pregnancy, antenatal surveillance should be expanded to enable early detection, stringent follow-up and timely intervention in severely affected pregnancies.
Primary or secondary wound healing of the Pin Sites After Removal of the External Fixator: Study Protocol for a Prospective, Randomized Controlled Mono-center Trial
Authors: Roth Franz , Cagienard Flavio , Link Björn-Christian , Hodel Sandro , Lehnig Drik , Babst Reto , Beeres Frank J.P. 
Published: January 2020

Abstract
Background: Temporary fixation with an external fixator is used for numerous indications in orthopedic trauma surgery. It is unclear whether primary wound healing or the secondary open wound healing after removal of the external fixator should be advocated for the pin site. This study compares primary wound closure with secondary wound healing for the pin sites. The primary aim is to compare the infections rates of the pin site. Secondary aim is to compare time to wound healing and esthetic outcome. The hypothesis was that primary wound closure does not lead to more infections than secondary wound healing. Methods: This is a prospective, randomized, controlled and blinded monocenter study based on a non-inferiority design. To obtain an equal patient population and groups, all pin entry sites of the patients are treated alternately at the time of removal of the external fixator with primary wound closure and secondary wound healing. Patients are randomized whether the proximal pin entry site is treated with wound closure or by secondary open wound healing, from which the further sequence develops. The pre- and postoperative protocol is standardized for all pin entry sites. A photo documentation of the pin entry sites takes place 2 and 52 weeks postoperatively during the routine clinically follow-up visits. Further controls take place after 6, 12 and 26 weeks after the removal. The primary outcome was to demonstrate the non-inferiority of primary wound closure compared to secondary wound healing in terms of postoperative wound infections according to center of disease control (CDC). The secondary outcomes are time to complete wound healing (days) and esthetical outcome (Subjective preference of patients and Vancouver scar scale). Discussion: This study aims in answering how to deal with the pin site after removal of the external fixator. To date, no routine and generally accepted protocol exists for the management of pin sites after removal of the external fixator. This prospective, randomized, blinded monocenter trial will answer if primary wound closure or secondary wound healing should be advocated after removal of the external fixator.
The effect of Xuanbai Chengqi decoction on patients with pneumonia-derived sepsis: study protocol for a randomized controlled trial
Authors: Jun Zhang , Yu Yi , Zheng Bojun , Jing Huang 
Published: January 2020

AbstractBackground: Sepsis and septic shock are major healthcare problems. pneumonia-derived is one of the important aspects of sepsis. The theory of traditional Chinese medicine (TCM) dictates that diseases of the lung and those of the large intestine react with each other. Methods/Design: A single-blind, randomised controlled clinical trial will be conducted involving 90 patients with pneumonia-derived sepsis. Participants will be randomised at a 1:1 ratio to receive Xuanbai Chengqi decoction (XCD) (experimental arm) or the same amount of saline treatment (control arm). The intervention will comprise one session/day for 1 week. The primary outcomes will be 28-day mortality, and levels of pro-inflammatory cytokines in bronchoalveolar lavage fluid and serum and static lung compliance, dynamic lung compliance, plateau pressure, and peak airway pressure, 1, 3 and 7 days after treatment completion with respect to baseline levels. Secondary outcomes will be the symptom score of traditional Chinese medicine, duration of parenteral nutrition, prevalence of complications and the course of antibiotic use. Measurements will be taken at baseline, 1, 3 and 7 days during the intervention, after 28 days after completing the intervention. Adverse events between arms will be evaluated. Discussion: This is the first trial to evaluate the effects of XCD on management of pneumonia-derived sepsis. If the results are as expected, they will provide evidence of XCD in promoting the results in pneumonia-derived sepsis patients. Trial Registration: Chinese Clinical Trial Registry, ChiCTR1900024072. Registered on 24 June 2019.