bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Challenges of Constructing the Connectivity between Indonesia and Malaysia in the Malacca Strait
Authors: Irewati Awani 
Published: October 2020

Today, people have lived in one integrated space that make all their needs and activities can be served quickly and they become interdependent . In line with that, the implementation of connectivity concept within community, automatically, becomes inherent in their social and economic activities.Therefore, people need to construct connectivity in all activities. Even within the bigger community like ASEAN Community, people become more involved in a cohesive and competitive situation in order to fulfill the desired goals. Referring to one of President Jokowi's maritime development programs, namely "Toll Laut", it is the Indonesia government's target to construct/ build up the potential regional zone as strategic hub that connects with its neighboring countries. The long-lived relationship between Indonesia and Malaysia in regards of the Malacca Strait has been articulated in numerous activities. This is in accordance with what the needs of coastal community of the two countries . In this case, Medan and Dumai of Sumatera Island in Indonesia are the two cities which have traditionally established people to people connectivity with Penang and Melaka cities of Malaysia. In the context of ASEAN Community, such a connectivity has been part of the ASEAN Community target. There are three elements inherent in the connectivity concept, namely infrastructures, institutions and people to people. The two Indonesia coastal regions in this regards need to construct the other two concepts of connectivity in order to obtain the “normal” connectivity which is the prerequisite to connect Indonesia and Malaysia in the Malacca Strait. This becomes a big challenge for the Indonesia to fulfill the target of competitive,cohesive and inclusive sub-regional connectivity development. This paper aims at scrutinizing the main quest, which focuses on the challenges faced by Indonesia in building up /constructing the maritime connectivity with Malaysia in the Malacca Strait. The paper is in favor of the argument that the Indonesia’s maritime corridors [Dumai and Medan] seem to have problem. The maritime connectivity between the two countries has not built adequately. In this regards, the government should streamline the management system linked to the internal connectivity issue.
The Tradition of Nyewu Shalawat in Pesantren Miftakhul Jannah, Central Java
Authors: Mahfudin Muhamad 
Published: October 2020

This research elaborates the practice of nyewu shalawat (recitation for the praise of the Prophet)) in Pesantren Miftakhul Jannah, Central Java. It focuses on the elaboration on the meaning of the prayers recited throughout the process of running the tradition. As a phenomenological study, it sees the tradition through the perspective of functional theory. It argues that the tradition held by the Pesantren is a sort of living hadith. Not only do the people engage in this tradition have some hadith as the basis, they also regard this tradition as a cult that must not be detached from their lives.
Análisis de la intervención antrópica en cuerpos de agua: caso caño Banderas, en el municipio Puerto López (Meta, Colombia)
Authors: Castro Garzón Hernando , Torres Flórez Dagoberto , Gallardo Lichaa Nadeska Jenniffer 
Published: October 2020

Resumen
Contexto: Puerto López se ubica en el nororiente del departamento del Meta, una distancia de 90 kilómetros de la capital, Villavicencio; es conocido como el centro geográfico de Colombia, y se caracteriza por ser una zona de riqueza hídrica. El caño Banderas es parte de la cuenca del río Meta, al que efluyen el 33 % de las aguas negras del casco urbano, y que se encuentra contaminado por las aguas residuales y basuras.
Método: A través de un enfoque mixto se recopiló información por medio de entrevistas semiestructuradas y encuestas, procesadas en Atlas.ti 7 y SPSS 20, respectivamente, estableciendo relaciones para la interpretación de resultados.
Resultados: Se estableció que los impactos generados no han sido mitigados a pesar de los diferentes programas determinados en la planeación municipal; la desigualdad en la condición ciudadana permite la ocupación como el detrimento de zonas de protección ambiental, a la vez que facilita los vertimientos y el depósito de residuos sólidos en ellas.
Conclusiones: Los análisis de la intervención antrópica de cuerpos de agua permiten establecer responsabilidades en los impactos negativos de la zona, así como pormenorizar acciones de mejora para su recuperación acordes al territorio.
Demokracja bezpośrednia wobec dążeń separatystycznych. Rozważania nad kategorią referendum niepodległościowego
Authors: Czapiewski Tomasz 
Published: October 2020

Celem niniejszego artykułu było ujęcie referendum niepodległościowego w ramach obecnych w nauce definicji i typologii oraz ukazanie głównych wątpliwości dotyczących politologicznych uwarunkowań oraz funkcji referendum niepodległościowego. Referendum niepodległościowe w większości przypadków uchodzi za szczególny instrument demokracji bezpośredniej i kluczowy etap procesu uzyskiwania własnej państwowości przez ruchy etnoregionalistyczne. Należy je zdefiniować jako głosowanie o charakterze powszechnym, w którym obywatele danego terytorium posiadający czynne prawo wyborcze mogą zadeklarować wolę utworzenia nowego państwa poprzez secesję. Referendum niepodległościowe jest pojęciem, w odniesieniu do którego widoczna jest istotna dysproporcja między liczbą badań empirycznych w formie studium przypadku a liczbą studiów o bardziej generalnym charakterze i teoretycznych ambicjach. Kluczowe problemy dotyczące analizy tej kategorii referendów to: określenie procedury referendum – sposobu inicjacji, warunków wstępnych, osób uprawnionych, treści pytania czy interpretacji wyników. Pamiętać należy o możliwości ustrojowego umocowania instytucji referendum, choć jej realizacja podlega wpływowi czynników bieżących oraz taktycznych decyzji politycznych aktorów, tak jak zwykłe głosowania powszechne.
Human Rights, Storytelling, and the Position of the Beneficiary: Antjie Krog's Country of My Skull
Authors: Schaffer Kay , Smith Sidonie 
Published: October 2020

In the end we are a society of people, not of ideas, a fragile web of interdependent humans, not of stances.—Pumla Gobodo-MadikizelaOne of the most compelling criticisms to emerge during South Africa's Truth and Reconciliation Commission (TRC) hearings called attention to the fact that those who benefited from the everyday policies and practices of the apartheid regime were neither identified as complicit in perpetuating systemic violence nor called to account. Nor was their implicated position in the apartheid state extensively analyzed in the commission's report. Commenting at the time on the inadequacy of the TRC process to identify beneficiaries of the apartheid regime and expose its structural violence, Mahmood Mamdani wrote that the TRC “has been interested only in violations outside the law, in benefits which are corruptions, but not in the systematic benefit which was conferred on beneficiaries at the expense of the vast majority of people in this country” (“Reconciliation” 3; also qtd. in Young 149). Mamdani here asserts that the ethical concept of the beneficiary is central to truth telling, reconciliation, and transitional nation building. His trenchant critique implicitly questions whether the truth-and-reconciliation project, relying as it does on the management of justice through the juridical statuses of “victim” and “perpetrator,” can deliver on its promise of addressing injustice and the aftereffects of radical injury and harm. Those positioned neither as victims nor as perpetrators are not called to recognize the benefits to them of structural violence, through which power, privilege, and “corporeal vulnerability” are unevenly distributed (Butler, Precarious Life 30). Nor are they asked to “bear moral responsibility to redress” the consequences of injustice (Mamdani, “Diminished Truth” 183). In response to Mamdani's critique, we want to consider how the ethical stance of the beneficiary can become visible in relation to victim and perpetrator positions and to what effect.
Our Puny Boundaries: Why the Craving for Carving Up the Nineteenth Century?
Authors: Wolfson Susan J. 
Published: October 2020

It's almost too convenient that carve evolves, via middle high german (kerben), from the greek graphein: “TO scratch, to write.” Ham-fisted or artful, the verb is the mark of desire, of a craving to inscribe. Given a century, carvings display cravings of the mind, motivated assignments in a march of years all beginning 18—. Figuring out how to carve one's shape in history, or how to carve history into shape, was a perplexity, a founding question even, at the dawn of the century:Who knows the individual hour in whichHis habits were first sown, even as a seed?[………]Hard task to analyse a soul in whichNot only general habits and desiresBut each most obvious and particular thought,Not in a mystical and idle sense,But in the words of reason deeply weigh'dHath no beginning.
Rocky Mountain Modern Language Association
Authors: Grenier-Winther Joan 
Published: October 2020

The Rocky Mountain Modern Language Association hosts an annual convention attended by more than four hundred scholars and teaching professionals. The 1999 convention in Santa Fe, New Mexico, included over one hundred regular, special-topic, and conjoint sessions on a wide variety of subjects.Established in 1947, the Rocky Mountain Modern Language Association is a nonprofit membership organization that promotes the study and teaching of language, literature, and culture. The RMMLA is one of six regional but independent branches of the Modern Language Association of America.
Psychosocial profile of women reporting with breast related symptoms and their association with time taken for presentation, a hospital based study
Authors: Sood Neelam , Sood Medhavi , Bansal Swasti , Singh Dweep Chand 
Published: October 2020

Background: The paper aims to study psycho-socio- demographic factors of women presenting with breast symptoms, find their correlations with (TTP).Methods: This cross sectional study was conducted in the Breast diagnostic clinic of a tertiary care hospital over a period of 2 months with the aim to approach all those women attending the breast diagnostic clinics and who had not started any treatment so far. The data collection was done using self-administered questionnaire and interview based questionnaire as required for a period of 2 months. 80 patients were included in the study. Their socio-demographic data, health seeking behaviour were collected and personality traits, life orientation and coping styles were assessed using the standardized tests. Descriptive, correlation analysis and stepwise linear regression followed by logistic regression, using SPSS20 software.Results: TTP was long with mean 6months. It was found to be negatively associated with size of the lump and education and positively with awareness about risk of cancer. Life orientation styles and personality traits showed no correlation. Pessimism was the seen in the majority of women.Conclusions: Education and increasing awareness about risk of cancer in the women can help them to report for treatment without delay. The understanding of coping skill, life orientation and personality domains and their relationship with TTP in the pre-diagnostic stage can help in future planning strategies during the course of treatment for breast cancer.
VAD Chemotherapy Versus Bortezomib Containing Regimens As Remission Induction For ASCT in Multiple Myeloma: A Single Center Experience
Authors: Şentürk Yıkılmaz Aysun , Akinci Sema , Mine Bakanay Şule , Dilek İmdat 
Published: October 2020

Background: Complete response (CR) and very good partial response (VGPR) are targeted with pre-ASCT induction regimens in patients by diagnosed multiple myeloma (MM), who are candidates for ASCT. In this study, it was aimed to compare the response and survival evaluations of cases who underwent induction treatment by vincristine-doxorubicin-dexamethasone (VAD) protocol versus bortezomib containing regimens.
Materials and Methods: The data of 96 ASCT eligible patients, retrospectively analyzed. P value> 0.05 was considered statistically significant.
Results: While 66 cases had received bortezomib containing regimens as induction regimen, 30 cases had received VAD protocol. The total survival was 91.3 (st.s 6) months and 43 (st.s 7.9) months, respectively, when we compared the cases without ASCT and with ASCT (p = 0.001). The OS of patients who underwent ASCT after reaching at least VGPR was longer than the underwent ASCT without reaching VGPR (p=0.019). Post-ASCT PFS (p=0.717) and OS (p = 0.126) analyzes were performed in 74 cases undergoing ASCT treatment, there was no significant statistical difference when patients with treated by VAD protochol and treated by bortezomib containing regimens as pre-ASCT induction regimens was compared to each other.
Conclusion: Whatever the type of induction regimen is, the level of response achieved before ASCT is important. The survival of the myeloma patients are much more influenced with HDT-ASCT as well as post-transplantation strategies to keep the patients in remission. Even though it is outdated, we think that the VAD protocol may be an option in patients who are not responding with the new generation of agents in the following days.
The Antihelminthic Drug, Mebendazole, Induces Apoptosis in Adult T-cell Leukemia/Lymphoma Cancer Cells: In-vitro Trial
Authors: Maali Amirhosein , Ferdosi-Shahandashti Elaheh , Sadeghi Farzin , Aali Ehsan 
Published: October 2020

Background: Adult T-cell leukemia/lymphoma (ATLL) is a poor prognostic Hematopoietic malignancy with various therapeutic challenges, which had been classified as non-Hodgkin lymphoma. The Drug switching, as a novel, innovative and promising approach, is an opportunity to overcoming on therapeutic challenges of hard-treating disease, e.g. ATLL. Our aim is evaluating the antiproliferative and apoptotic effect of Mebendazole (MBZ) on ATLL cancer cells in in-vitro conditions.
Materials and Methods: We used Jurkat cell-line as ATLL cancer cells. After treatment of MBZ in different concentrations on jurkat cells, the cell viabilities were determined by MTT assay. After IC50 value determination, the 24-, 48- and 72-h treatments had been performed in IC50 concentration and control to evaluating the quantitative apoptosis rate by Annexin/PI Flowcytometry and qualitative apoptosis by DAPI Nuclear staining. Also, Glucose spectrophotometry were performed to evaluate the reduced amount of glucose uptake through MBZ treatment.
Results: MBZ inhibits proliferation of jurkat cells and IC50 value had been estimated 10 μM (P< 0.01). According to the flowcytometric results, increasing in drug concentration is associated with decrease cell viability and the percentage of full-apoptosis. However, it inversely correlates with percentage of early-apoptosis rate. Also, the microscopic captures of DAPI Nuclear staining confirms the flowcytometry results in qualitative manner. In addition, it was found that inhibition of glucose uptake was inversely correlated with increased MBZ concentration (P< 0.05).
Conclusion: MBZ potentially inhibits the proliferation of ATLL cancer cells in in-vitro condition. MBZ inhibits the growth of Jurkat cells by inducing apoptosis. Also, we suggest that indirectly inhibition of Glucose transporting occurs by MBZ, which could induce apoptosis in cancer cells.
PERUMUSAN STRATEGI PENGEMBANGAN BUMDes DI DESA MEKARBAKTI, KABUPATEN SUMEDANG
Authors: Kanti Runita Arum , Sofia Poppy 
Published: October 2020

The economic potential of a village needs to be developed and managed properly in order to provide sustainable benefits for the village. One of the instruments to realize this goal is the Village Enterprises, known as the BUMDes. BUMDes, is a business entity whose capital is wholly or mostly owned by the Village through investments from the Village and are created to manage assets, services, and other businesses to generate welfare for the its community. Mekarbakti Village is one of the villages in Sumedang Regency which has a variety of economic potential. This research seeks to formulate an optimal strategy for developing BUMDes in Mekarbakti Village through the use of the Village economic potential. The approach used in this research is descriptive research. The data used are primary data taken from interviews. The results of this research are three strategies for developing BUMDes obtained through a SWOT analysis.

Keywords: Village enterprise, strategy, development, economic potential, SWOT.

ABSTRAK
Potensi ekonomi desa perlu dikembangkan dan dikelola dengan baik agar memberikan manfaat yang berkelanjutan bagi desa. Salah satu instrumen yang mampu mewujudkan hal tersebut adalah pendirian Badan Usaha Milik Desa atau dikenal dengan BUMDes. BUMDes, adalah badan usaha yang seluruh atau sebagian besar modalnya dimiliki oleh Desa melalui penyertaan secara langsung yang berasal dari kekayaan Desa yang dipisahkan guna mengelola aset, jasa pelayanan, dan usaha lainnya untuk sebesar-besarnya kesejahteraan masyarakat Desa. Desa Mekarbakti merupakan salah satu desa di Kabupaten Sumedang yang memiliki beragam potensi ekonomi. Penelitian ini berusaha merumuskan strategi optimal guna mengembangkan BUMDes di Desa Mekarbakti melalui pemanfaatan potensi ekonomi Desa. Pendekatan yang digunakan dalam penelitian ini adalah penelitian deskriptif. Data yang digunakan merupakan data primer yang diambil dari wawancara. Hasil dari penelitan ini adalah bahwa terdapat tiga strategi pengembangan BUMDes yang diperoleh melalui analisis SWOT.

Kata kunci: BUMDes, strategi, pengembangan, potensi ekonomi, SWOT.
Quantitative analysis of TMT phosphorylation modification to investigate the effect of verbascoside on the expression of phosphorylated protein in AD cell model
Authors: Xing Haiyan Xing Haiyan , Dong Zhiqiang Dong Zhiqiang , Li Gang Li Gang , Du Xiaoli Du Xiaoli , Fan Lei Fan Lei , Wang Shengnan Wang Shengnan , Zhao Lulu Zhao Lulu , Gu Chao Gu Chao , Gao Yuan Gao Yuan 
Published: October 2020

Abstract
Background—The active monomer Verbascum glycosides in Cistanche tubulosa has good development prospects in terms of neuroprotection and delaying neurodegenerative diseases, and it has become one of the research hot spots. To investigate the effect of verbascoside (OC1) on the expression of phosphorylated protein in the protective effect of AD cell model by TMT labeling and phosphorylation enrichment technique and high-resolution liquid chromatography-mass spectrometry quantitative proteomics research strategy. Methods—The normal control group, the model group Aβ1-42(10μmol/L) group and the OC1(10μg/ml) administration group were set. (1)protein extraction quality control. (2)TMT mark. (3)HPLC classification and modification enrichment. (4)Analysis of mass spectrometry by liquid chromatography-mass spectrometry. (5)Analysis of bioinformatics results. (6)Western Blotting was used to detect the expression levels of p-CaMKII(Thr286), p-Synapsin1(Ser603)/Synapsin1, Synaptophysin and Synaptotagmin-1 protein. Results—The study finally identified 9020 phosphorylation sites on 3227 proteins, of which 8635 sites of 3134 proteins contained quantitative information. Screening of differential sites follows the following criteria: 1.2 times the change threshold and CV value < 0.1. Based on the above data and standards, we performed a systematic bioinformatics analysis of proteins containing quantitative information sites. Western Blotting results showed that Verbascoside could promote the expression of p-CaMKII (Thr286), p-Synapsin (Ser603)/Synapsin, Synaptophysin and Synaptotagmin-1 protein. Conclusions—Verbascoside(OC1) can increase the expression of phosphorylated protein in AD cell model, which provides a basis for further study on the molecular mechanism of verbascoside promoting neurotransmitter release.
Access to health care for gaming disorder: A patient-centred approach to address the continuum of need
Authors: Park Jennifer J , Wilkinson-Meyers Laura , King Daniel L , Rodda Simone 
Published: October 2020

Abstract
Background Problematic gaming, including its most serious form known as gaming disorder (GD) in the ICD-11, affects approximately 1-3% of the population and can have significant negative impacts on health and wellbeing. Research to determine the optimal health system responses to GD remains limited. This study aimed to identify and describe the key components of a patient-centred approach to prevention, early intervention, and treatment of GD. Methods Online interviews were conducted with 20 adults (90% male; Mage=23y) currently seeking help for GD. The interview protocol was guided by a health care access framework which investigated participants’ experiences and needs related to accessing professional support. Transcripts were analysed in NVivo using qualitative content analysis to systematically classify participant data into the themes informed by this framework. Results Although the characteristics and resultant harms of GD were broadly recognised, participants indicated that these issues may not always be viewed by healthcare providers as a serious problem that requires intervention or that could be addressed through treatment. This highlights a significant barrier to access at the beginning of the patient journey when patients may perceive that they have a legitimate need for care and seek a relevant, tailored, and safe service to meet this need. Participants described the essential components of an effective health service for GD as including: valid and reliable screening tools for GD; practitioners with specialist knowledge of GD that includes, or is strongly informed by, lived experience of peers; and access to a multimodal system of intervention, including self-help, internet and face-to-face options that allow gamers to transition between types and intensity of support. Conclusion A comprehensive health care approach for gaming disorder is currently in its infancy and there are numerous service access and delivery issues still to be resolved. This study highlights the importance of involving individuals with GD in developing solutions that are fit for purpose and address the spectrum of intervention needs. These findings recommend a stepped GD healthcare system that adheres to evidence-based practice tailored to each individual and the implementation of standard assessment and routine outcome monitoring.