bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time allocation to active daily domains, physical activity, and health indicators in older adults: Cross-sectional results from the OUTDOOR ACTIVE study.
Authors: Stalling Imke , Albrecht Birte Marie , Doerwald Friederike , Bammann Karin 
Published: July 2020

Abstract
Background
Physical activity (PA) is one of the key determinants of healthy ageing. Research showed that time allocation plays an important role in PA. Therefore, an understanding of the time use of older adults is crucial for developing PA programs. The aim of this study was to examine the associations of time allocation and objectively measured PA, and several health indicators in older adults.
Methods
In this cross-sectional study all 915 participants of the OUTDOOR ACTIVE study were included. The participants were 65 to 75 years old and resided in a subdistrict of Bremen, Germany (50.9% female). The active daily domains were derived from the SLOTH model (leisure activities, occupation, active transport, home-based activities). PA was objectively measured with accelerometers over seven consecutive days. Binary logistic regressions were used to test the associations of total PA and time spent in the domains with several health indicators (self-rated health, overweight, obesity, activities of daily living (ADL), handgrip strength).
Results
Participants over the age of 70 years were significantly less physically active than those under 70 years and women were significantly more physically active than men. Regardless of age and sex, most time was spent on home-based activities (women: 118.5 ± 87.8 min/day; men: 80.2 ± 69.4 min/day). Both PA and time spent on leisure activities were associated with a lower risk of bad self-rated health (0.36; 95%-CL: 0.20, 0.65 for PA; 0.93; 95%-CL: 0.87, 0.99 for leisure activities) and less limitations in ADL. PA and active transport seemed to lower the risk of overweight (0.39; 95%-CL: 0.25, 0.62 for PA; 0.80; 95%-CL: 0.69, 0.93 for active transport) and obesity (0.36; 95%-CL: 0.21, 0.60 for PA; 0.77; 95%-CL: 0.64, 0.92 for active transport). Having an occupation was associated with a lower risk of bad self-rated health (0.60; 95%-CL: 0.40, 0.92).
Conclusions
The results of this study provide insights in the time allocation to active daily domains and total PA of older adults, as well as the associations with health indicators. These findings have important implications for the development of PA programs. Future research should examine the associations further in longitudinal studies.
Epidemiological features and hotspot of COVID-19 in Isfahan province of Iran: Results of a cohort study
Authors: Janani Majid , Beheshti-Nia Fereshte , Ahmadi Hamzeh , Khazeni Atefeh , Yadegarfar Ghasem 
Published: July 2020

Abstract
Background and Aim: The aim of this study was to description of the epidemiological features and hotspot of COVID-19 in Isfahan province of Iran.Method: In this descriptive, retrospective cohort, multicenter study, all patients admitted to one of the hospitals or health networks of Isfahan province from 3rd February to 13th June 2020 due to RT-PCR (Reverse transcription-polymerase chain reaction) test were enrolled to study. Trained staff followed up participants for two weeks by a Telephone number, and the outcome was recorded.Result: Up to 13 June, 41,498 patients recruited and their data were analyzed; the incidence of COVID-19 was 27.5% (95% CI: 27.1, 28.2). Among the participants with the positive test, 93.2% of them, treated by outpatient basis or discharged, 2.1% were hospitalized, and the case fatality rate (CFR) was 4.8%. Khansar and Aradestan was the hotspot of COVID-19 and had the highest incidence among cities of Isfahan province. Najafabad, Khomeinishahr, and Shahinshahr&Meymeh had the highest imported cases of COVID-19 to the capital of Isfahan province, Isfahan city. Also, Charmahal & Bakhtiari, Khuzestan, and Fars provinces had the highest number of imported cases from other provinces to Isfahan city. We found that 77.3% of intra-province imported cases and about 83% of inter-province cases were imported after reducing lockdown.conclusion: The incidence and fatality of COVID-19 in Isfahan province is alarming. Inter-city and inter-provincial unnecessary travels have a high impact on the transmission and spread of the COVID-19. Applying more restrictions will prevent this from happening. It is advised to restrict the inter cities travels again by policy makers for the benefit of public health.
Exosomes synthesizing HER2 miRNA and engineered to adhere to HER2 on surface tumor cells exhibit enhanced anti-tumor activity
Authors: Wang Lei , Zhou Xusha , Zou Weixuan , Wu Yinglin , Zhao Jing , Chen Xiaoqing , Zhou Grace Guoying 
Published: July 2020

Abstract
Introduction: Exosomes are small vesicles derived from cellular membranes with a diameter of 50–150 nm. Exosomes are considered to be ideal drug delivery systems with a wide range of application in various diseases including cancer. However, nonspecific delivery of therapeutic agents by exosomes in vivo remains a challenging. Human epidermal growth factor receptor 2 (HER2) is an epidermal growth factor receptor tyrosine kinase. Overexpression of HER2 is usually associated with cancer survival and progression in various cancers. In this study, we aimed to develop the novel exosomes with dual HER2-targeting ability as nanoparticle delivery vehicle to enhance anti-tumor efficacy in vivo.Results Here we report the construction of two kinds of exosomes carrying designed miRNA to block the synthesis of HER2 and as a consequence to kill the tumor cells. The 293-miR-HER2 exosomes package and deliver designed miRNA to cells to block HER2 synthesis. These exosomes kill cancer cells dependent on HER2 for survival but have no effect on cells lacking of HER2 or which were engineered to express HER2 but do not depend on it for survival. The 293-miR-XS-HER2 exosomes carry one more peptide, which enables the exosome to adhere HER2 on the surface of the cancer cells. In consequence these exosomes preferentially enter and kill cells exhibiting HER2 on their surface. The 293-miR-XS-HER2 exosomes are significantly more effective in shrinking the size of HER2-positive tumors implanted in mice than the 293-miR-HER2 exosomes.Conclusion Collectively, as novel anti-tumor drug delivery vehicles, the HER2 dual-targeting exosomes has increased target-specific delivery efficiency, which can be further utilized to develop new nanoparticle targeted therapy.
Utilization of Non-Pharmacological Methods and the Perceived Barriers for Adult Postoperative Pain Management by the Nurses at Selected National Hospitals in Asmara, Eritrea
Authors: Kidanemariam Betiel Yihdego , Elsholz Traudl , Simel Laban L. , Tesfamariam Eyasu H. , Andemeskel Yonatan M. 
Published: July 2020

Abstract
Background
Postoperative pain remains a concern to both patients and health care professionals. Non-pharmacological pain relief methods have the potential to complement pharmacological interventions and may offer alternative treatment options. The aim of the study was to assess nurses’ utilization of postoperative nurses’ non-pharmacological pain relief methods and the perceived barriers for their implementation in the National Hospitals.
Methods
Descriptive cross sectional study was conducted among 154 nurses working at the National Referral Hospitals and Sembel Private Hospital. A standardized five-point Likert-scale questionnaire which assesses nurses' utilization of selected non-pharmacological methods and the perceived barriers for the implementation of those methods were used to collect data. Descriptive statistics for the demographic data, independent samples t-test and one way ANOVA for the nurses’ utilization of the non-pharmacological methods and perceived barriers were used to analyze the data. Statistical significance level was set at P < 0.05.
Results
The study found that emotional support (45.5%), helping with daily activities (67.5%) and creating a comfortable environment (61%) were reported to be the most frequently used methods, whereas the cognitive-behavioral (5.9%) and physical methods (5.8%) were found with less frequency. The results also show that characteristics, such as the nurses' age (p = 0.013), education (p = 0.012), work experience (p = 0.001) and place of work (p = 0.001), were significantly related to the use of non-pharmacological methods. Among the various perceived barriers, health care system related barriers such as heavy work load (87.7%), shortage of time (84.4%), limited resources (82.5%), deficit in the guidelines for pain management (77.3%), lack of administrative support (76.6%) followed by patient related barriers such as patients uncooperative behavior (57.1%) were identified.
Conclusion
Only few of the non-pharmacological methods were found to be utilized by the nurses as pain relieving strategies and various perceived barriers are existing among the nurses towards the utilization of these methods. Nurses in these settings need training and education on non-pharmacological pain relief methods, particularly on methods that are utilized less often.
How well are general practitioners informed about chronic kidney disease?
Authors: Haddiya Intissar , Elgharab Jalal , Bentata Yassamine 
Published: July 2020

Abstract
Background In most health systems, general practitioners (GPs) are the frontline caregivers. They, thus, should have the appropriate knowledge in order to detect, manage and refer patients to the specialist at the right time. In the context of Chronic kidney disease (CKD), a major public health issue, they have an important role to play in the care process. The purpose of this paper was to evaluate their CKD related knowledge.Methods We have performed a Cross-sectional survey, in the last trimester of 2019, that had included GPs practicing in Eastern morocco, using a Googleform questionnaire, based on the KDIGO 2012 guidelines.Results Our respondents’ mean age was 42.4 ± 11.26 years old. 59% of them were women. Mean seniority in general practice was 14.3 ± 9.9 years. 64.47% worked in the public sector. 52.63% of GPs had insufficient CKD related knowledge. Less than half of the physicians could select the correct definition of CKD and only 29.61% knew that it is classified into five stages. Other than diabetes and high blood pressure, other CKD risk factors were identified by 38.15% of GPs. In addition, only 39.4% of the participants knew about peritoneal dialysis.Conclusion Our study concluded to GPs’ lack of CKD related knowledge. The continuing medical education of these frontline practitioners is mandatory in order to ameliorate patients management.
Fabrication of Al2O3-coated BiFeO3 particles and fine-grained ceramics with improved electric properties
Authors: Bai Peijia , Li Yutong , Wang Gang , Han Jiao , Wei Yongxing , Li Mingwei , Mao Duan , Zeng Yiming 
Published: July 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
An assessment of the livelihood vulnerability of climate induced migrants: A case study on Sagar Island, India
Authors: Bera Aparna , Singh Suraj Kumar 
Published: July 2020

Abstract
The effects of climate change are causing large scale human displacements all over the World over past few decades and climate refugees are putting biggest challenges to the geophysical biological and social system. This paper attempts to assess the vulnerability of both the refugee and regular settlers of selected mouzas of Sagar Island, south 24parganas, India where people are witnessing their lands vanishing under their feet in these constantly sinking and shrinking deltaic estuaries. Findings of LVI and LVI-IPCC analysis indicate that the climate induced migrant communities are more exposed to climatic variability due to poor adaptive capacity. Poor access to food, water, health facilities are making them extremely vulnerable with lower resilience as these mouzas are facing frequent flooding, severe coastal erosion, embankment breaching and higher storm surges on an annual basis. The outcomes of this study could be beneficial for effective on site risk management, adaptation strategies and further planning propositions.
Prevalence of Physical Inactivity and Sedentary Behaviors and Associations with Obesity among Saudi Adults
Authors: Althumiri Nora A , BinDhim Nasser F , Alqahtani4 Saleh A. 
Published: July 2020

Abstract
Background: Worldwide, physical inactivity is ranked as the fourth leading risk factor for mortality. This study aimed to provide an update on the prevalence of physical inactivity and sedentary behavior among adults in Saudi Arabia and to examine associations with obesity.Methods: This study was conducted as secondary analysis of a national survey that was conducted in Saudi Arabia in 2018. In this study, a proportional quota-sampling technique was used to obtain equal distributions of participants, stratified by age and gender, across the 13 regions of Saudi Arabia. Participants (n = 3,699) were recruited mainly via random phone interviews. The World Health Organization (WHO) recommendations (150 minutes of moderate activity/week or 75 minutes of intensive activity/week) were used to classify physical activity. Logistic regression was used for multivariate analysis.Results: The prevalence of physical inactivity (not meeting the WHO recommendations) ranged between 66.8% and 81.2%. Females and males did not differ in their frequency of physical activity. Participants spent an average of 275 minutes/day watching TV or using phone apps and 267 minutes/day doing office work. Physical inactivity was associated with increased likelihood of obesity (BMI ≥ 30), as compared to those who met the WHO intensive physical activity criteria (odds ratio [OR]: 1.62; 95% CI: 1.23–2.13) and to those who met WHO mixed intensive/moderate physical activity criteria (OR: 1.49; 95% CI: 1.24–1.81), adjusted for age and gender. However, sitting long hours for work or leisure was not significantly associated with obesity.Conclusions: Future research is needed to identify public health interventions that would be most feasible and suitable for physical inactivity and sedentary behavior reduction at the national level for national implementation; and health policies are needed to facilitate sustainability.
Analysis of the mountain sickness of tourists in China from 2015-2017
Authors: Li Xiang , Xie Chaowu 
Published: July 2020

Abstract
Background: Mountain sickness significantly affects tourists who travel in plateau areas. Most studies have researched patients, climbers and local residents to analyse the identification, causes, symptoms and effects of mountain sickness, and only a few have assessed tourists.Methods: This study used the Jiangtai Insurance Broker, an exemplary underwriting platform for travel agency liability insurance in China, as the data acquisition platform to analyse tourist altitude sickness from an epidemiological perspective. The chi-square test was used to test the distribution of mountain sickness diseases and symptoms among different genders and ages. A geographic information system (GIS) was used to generate a spatial distribution map of tourist mountain sickness.Results: From 2015 to 2017, there were 361 cases of tourist mountain sickness, which were distributed in 4 altitudinal classes. The incidence of mountain sickness was higher in women than in men. Tourists aged 40-69 years were the main group of patients. Acute mountain sickness (AMS) and high-altitude pulmonary edema (HAPE) were the main high-altitude diseases and mainly occurred in the 2nd and 3rd class altitude regions. Hypoxia, dizziness, headache and chest tightness were the main symptoms of mountain sickness. Spring, summer and autumn were the peak seasons for the onset of mountain sickness. Mountain sickness cases were concentrated in a few cities in Western China.Conclusion: This study analysed the genders and characteristics of the main tourist population that suffered from mountain sickness and investigated the diseases and the temporal and spatial regularity of disease from an epidemiological perspective. The research showed that the onset of mountain sickness was related to the individual physique and age of tourists, speed of entering the plateau, season and altitude. This study is significant as a reference for the risk assessment of tourists visiting plateau areas.
Evaluating Implementation of The Diabetes Perioperative Passport: A Qualitative Focus Group Study
Authors: Akiboye Funke , Page Emma , Nirantharakumar Krish , Rayman Gerry , Lindenmeyer Antje 
Published: July 2020

Abstract
Aims To examine the factors affecting implementation of an empowerment tool for patients with diabetes in two surgical groups within a single district general hospitalBackground A perioperative passport was developed to improve care of people with diabetes undergoing elective surgery by equipping patients with a hand-held summary of their care needs. Two surgical groups were approached to be involved in developing and piloting this novel technology with contrasting results. Design A qualitative study using focus groups to examine factors affecting staff engagement in implementing the diabetes perioperative passport.Methods Two focus group were conducted in 2017 with pre-operative nurses in the departments of orthopaedics and general surgery of an NHS trust (N= 8). Audio-taped group discussions were transcribed, and the data coded and analysed to identify themes.Results The general surgical nurse group generally supported each other’s views and comments. They were enthused about the passport throughout. In contrast, the orthopaedic specialist nurse group had initial reservations about implementing the passport, but as the focus group unfolded, they moved from sharing individual views to finding commonalities and became more engaged and motivated to use the passport. Conclusion Focus groups are a practical and efficient tool to conduct within the usual working environment of an NHS hospital. In addition to capturing information about the challenges to implementation they may serve as a crucial implementation tool where evidence-based practice has not been adopted. Impact This is the first study carried out in the NHS setting highlighting the benefit of focus groups as a practical implementation tool.
Identifying Side Effects of Some Drugs Used in Covid-19 Treatment
Authors: Aygün Irfan , Kaya Mehmet , Alhajj Reda 
Published: July 2020

Abstract
To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. Organ systems and diseases in which these 8 drugs cause the most negative effects have been identified. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental results obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient.
The scope and nature of sexual orientation and gender identity and expression change efforts: A systematic review protocol
Authors: Kinitz David J , Salway Travis , Dromer Elisabeth , Giustini Dean , Ashley Florence , Goodyear Trevor , Ferlatte Olivier , Kia Hannah , Abramovich Alex 
Published: July 2020

Abstract
Background: Sexual orientation and gender identity and expression change efforts (SOGIECE) are a set of scientifically discredited practices that aim to deny and suppress the sexual orientations, gender identities, and/or gender expressions of sexual and gender minorities (SGMs). SOGIECE are associated with significant adverse health and social outcomes. SOGIECE continue to be practiced around the world, despite denouncements from professional bodies and survivors, as well as calls for legislative advocacy to prohibit SOGIECE and protect SGMs. There are substantial gaps in the availability of consolidated international research to support and refine legislative proposals related to SOGIECE, including those currently underway to enforce bans in Canada and elsewhere.We therefore propose the first systematic review of international data on SOGIECE that will outline the scope and nature of these practices worldwide. Specifically, we aim to estimate how many SGMs have been exposed to SOGIECE, which sub-groups of SGMs experience higher rates of SOGIECE, and how estimates of SOGIECE vary over time and place. In addition, we aim to describe when, where, how, and under what circumstances SGMs are exposed to SOGIECE.Methods: To locate an interdisciplinary swath of papers, nine (9) bibliographic databases will be searched: Medline (OVID), Embase (OVID), PsycINFO and Social Work Abstracts via EBSCO, Web of Science Core Collection, LGBT Life with Fulltext, Proquest Dissertations & Theses Global and Sociology Collection (ProQuest). A gold standard search will be developed for Medline and adapted to the other databases. Grey literature will be searched at relevant websites, and reference harvesting will be performed in relevant SOGIECE scientific consensus statements. Two authors will independently screen abstracts/titles, screen full texts, abstract data, and apply risk of bias assessments. A narrative synthesis will be implemented to summarize findings.Discussion: This review will address the gap in synthesized data regarding the prevalence of SOGIECE, social correlates of SOGIECE, variations of SOGIECE over time and place, and the circumstances, settings, and time-points of SOGIECE exposure. Findings from this review will directly inform ongoing and new legislative efforts to ban SOGIECE and other interventions that aim to stem SOGIECE practices and support SOGIECE survivors. Systematic Review Registration: Prospective registration with PROSPERO will occur before completion of full-text screening.