bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations Between COVID-19-Related Changes to Pregnant Women’s Work-Plans and Prenatal Depression
Authors: Sherin Margaret , Gildner Theresa E. , Thayer Zaneta M. 
Published: October 2020

Abstract
Purpose: To identify whether COVID-19-related changes to how long pregnant women planned to work in pregnancy were associated with depression.Methods: An online convenience sample of pregnant women in the U.S. were recruited in April-May 2020 (N = 1,970) through social media and dissemination to U.S.-based maternal health contacts. We used multivariate logistic regression to evaluate whether COVID-19-related changes to pregnant women’s work-plans were associated with clinically-significant prenatal depression (Edinburgh Postnatal Depression Survey score >=15), adjusting for covariates.Results: Of the 1,600 eligible participants without missing data, 29.6% of participants (N = 473) reported that they experienced a COVID-19-related work-plan change, while 22.1% (N = 350) of participants had a clinically-significant EPDS score. Women were more likely to report a work-plan change if they were younger (t(1598) = 2.90, p<0.004), had a lower household income (𝛘2(2) = 29.63, p<0.001), were less educated (𝛘2(2) = 27.48, p<0.001), were farther along in pregnancy (t(1598) = -4.96, p<0.001), and worked outside the home during COVID-19 (𝛘2(2) = 59.27, p<0.001). Both COVID-19-related work-plan changes (OR = 1.74 , 95% CI 1.34 – 2.25, p < 0.001) and uncertainty about the nature of these changes (OR = 2.70, 95% CI 1.22 – 5.96, p = 0.014) were associated with significantly higher odds of a clinically-significant depression score.Conclusion: Pregnant women who experienced a work-plan change or who were uncertain about how COVID-19 would impact their work-plans were significantly more likely to experience depression, suggesting a need for universal access to prenatal depression screening and paid maternity leave.
Uncommon Giant Corneal Keloid: A Case Report and Literature Review
Authors: Li Shang , Jiang Lei , Xu Xiaolin , Yang Ke , Jie Ying 
Published: October 2020

Abstract
Background: Corneal keloid is a rare kind of clinical disease. Surgery is the only treatment in the end, but the literature reports vary. This is a case study of the diagnostic and treatment course for a patient with giant corneal keloid.Case presentation: A 36-year-old young man was admitted to the hospital because of a large mass on the surface of the left cornea. A slit lamp examination revealed that the lesion covered the entire cornea and protruded from the surface of the eyeball, so that the left eyelid could not be closed normally. B-scan of the eye showed that the internal structure of the left eye was normal. The mass was surgically removed and send for pathological examination, and then the ocular surface reconstruction was taken by deep anterior lamellar keratoplasty. Histopathologic study showed irregular epithelium, the absence of Bowman’s layer and hyperplastic collagen fibers, which are consistent with the diagnosis of corneal keloid. Immunohistochemical revealed positive staining for vimentin in lesion subject and smooth muscle actin (SMA) in vascular wall. The corneal graft remained clear 4 months after surgery and the patient was satisfied with the visual outcome. A final diagnosis of giant corneal keloid was reached.Conclusion: Corneal keloid should be suspected in cases of enlarging white glistening corneal nodule after trauma. Deep anterior lamellar keratoplasty is one of the effective surgical option for corneal keloids.
Bleeding Risk Stratification in Coronary Artery Surgery the Should-Not-Bleed Score
Authors: Petricevic Mirna , Petricevic Mate , Pasalic Marijan , Cepulic Branka Golubic , Raos Mirela , Vasicek Vesna , Goerlinger Klaus , Rotim Kresimir , Gašparović Hrvoje , Bojan Biocina 
Published: October 2020

Abstract
BackgroundCardiac surgery has an estimated 20% of the total blood transfusions. Of those, 11% were utilized in patients undergoing coronary artery bypass grafting (CABG) with documented wide variability in transfusion rate (7.8% to 92.8%). To address the issue of unnecessary transfusions within CABG population, we developed the model to predict the patients at low risk of bleeding who should not be transfused. Herein we present our “SHOULD-NOT-BLEED-SCORE” application developed for Windows® software platform and based on our previous research.MethodsThis study aimed to develop the user-friendly application that stratifies the patients with respect to bleeding risk. The statistical model we used in our previous research was focused on detection of CABG patients at low risk of bleeding. The rationale behind such an approach was to identify among CABG patients subgroup at low risk of bleeding. By identifying patients at low risk of bleeding we can define the subgroup of patients who should not be transfused. We developed the Windows platform application based on risk modelling we previously calculated on 1426 patients undergoing elective CABG from January 2010 to January 2018.ResultsThe SHOULD-NOT-BLEED-SCORE risk score is developed for Windows software platform. The mathematical model based on multivariate analysis was used for app development. The variables that entered the scoring system were: Age; Body Mass Index; Chronic Renal Failure; Preoperative Clopidogrel Exposure; Preoperative Red Blood Cells Count; Preoperative Fibrinogen Level; Preoperative Multiplate ASPI test (AUC). The SHOULD-NOT-BLEED-SCORE identifies/predicts patients without excessive bleeding with the strong discriminatory performance (ROC analysis AUC 72.3%, p<0.001).ConclusionThe SHOULD-NOT-BLEED risk scoring application may be useful in preoperative risk screening process. The clinical and economic burden associated with unnecessary transfusions may be adequately addressed by preoperative scoring system detecting patients at low risk of bleeding who should not be transfused.
Epidemiology of Influenza Virus Reinfection: A Retrospective Analysis of a Nine-year Influenza Surveillance Data
Authors: Wang Jing , Jiang Lina , Xu Yunan , He Weitao , Zhang Chao , Bi Fuyin , Tan Yi , Ning Chuanyi 
Published: October 2020

Abstract
BackgroundEpidemiological characteristics profile of the reinfection of the influenza virus has not been well described. MethodsOur study estimated the reinfection rate using nine-year influenza surveillance data and further examined the characteristics associated with the reinfection. ResultsA total of 53,605.6 person-months and the median time of 8.7 months were observed for reinfection. The cumulative reinfection incidence was 2% at 6 months, 4% at 12 months, 5% at 24 months, and 7% after 59 months. Living in the rural area (HR=1.37 [95% CI 1.29-1.45]), and age ≤6 years (HR=11.43 [95% CI 9.47-13.80]) were independent risk factors associated with influenza reinfection. ConclusionsOur findings indicate that the reinfection of the influenza virus in Guangxi independently and positively associated with the rural area and younger age. The unusually high frequency of reinfection points to a need for further prospective longitudinal studies to better investigate sufficient impact on the development of broadly protective or universal vaccines.
Effects of Soil and Water Conservation Measures on Selected Soil Physicochemical Properties: The Case of Ejersa Lafo District, Central Highlands of Ethiopia.
Authors: Mammo Siraj , Tolesa Adugna , Bohnett Eve 
Published: October 2020

Abstract
BackgroundLand degradation in the form of soil erosion and fertility depletion is the major environmental problem in Ethiopia. However to curb this problem, Soil and Water conservation (SWC) measures are commonly practiced in many rural parts of Ethiopia. This study was conducted to assess the effects of SWC measures on selected soil quality indicators in Ejersa Lafo District. For this study two peasant associations (kebeles) were selected from the district based on the severity of soil erosion and information on SWC practices. A total of 12 composite soil samples from soil 0 to 20cm depth from two sub watersheds with SWC and without SWC practices at Jamjam laga batu and Koriso Odo guba from three landscape positions (upper slope, middle slope, and bottom) were collected. All the soil samples were analyzed following the standard and recommended procedures in Ambo University chemistry laboratory and subjected to ANOVA using the SPSS computer program. ResultMost of the selected soil physicochemical properties were affected by watershed management intervention. Comparing the two farmlands, the highest bulky density of 1.37gcm-3 was observed from unconserved farmland. The results of the study also showed higher values of Soil electrical conductivity (EC), Total nitrogen (TN), Cation exchange capacity (CEC), Soil Organic matter (SOM), Organic Carbon, Available Phosphorus (Av. P) and Available Potassium (Av. K) in conserved land and those all significantly varied between farm plots. On the other hand, Sandy, pH, SOM, TN, Av. P and Av. K values were significantly affected (p<0.05) by slope and all increased from upper (>30%), middle (15-30%) and lower (8-15%). ConclusionThe contribution of watershed management intervention to improve soil physicochemical properties is significant in the study area as it improved some of the selected soil physicochemical properties of soil. Furthermore, efforts are required to enhance community adoption towards soil and water conservation. Additionally, further research has to be carried out on socio-economic aspects and impacts of the intervention on crop productivity for better understanding of the sustainable use of the land and to make a comprehensive conclusion.
Cognitive Reserve Proxies, Alzheimer Pathologies, and Cognition
Authors: Ko Kang , Yi Dahyun , Byun Min Soo , Lee Jun Ho , Jeon So Yeon , Kim Woo Jin , Byeon Gihwan , Sung Kiyoung , Han Dongkyun , Lee Young Hwa , Joung Haejung , Jung Gijung , Lee Jun-Young , Kim Heejung , Kim Yu Kyeong , Kang Koung Mi , Sohn Chul-Ho , Lee Dong Young 
Published: October 2020

Abstract
BackgroundLimited information is available regarding which of the commonly used cognitive reserve (CR) proxies are more appropriate to precisely reflect moderation effect for the relationship between a specific Alzheimer’s disease (AD) pathology and cognitive decline. We examined the moderating effects of the frequently used four CR proxies [i.e., education, premorbid intelligence quotient (pIQ), occupational complexity (OC), and lifetime cognitive activity (LCA)] on the relationships between various in vivo AD pathologies and cognitive decline. MethodsThis study included 361 older adults (268 cognitively unimpaired, 52 mild cognitive impairment with beta-amyloid (Aβ) deposition, 41 AD dementia with Aβ deposition). All participants underwent multi-modal brain imaging including [11C] Pittsburgh Compound B positron emission tomography (PET), [18F] Fluorodeoxyglucose-PET, and magnetic resonance imaging to measure AD pathologies as well as comprehensive clinical and neuropsychological assessments. Information on education, pIQ estimated with an adult reading test, OC, and LCA was obtained. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery total score (CERAD-TS) was used as the cognitive measure. We used linear regression model predicting cognition to examine the interactions of each CR proxy and each AD pathology.ResultsAmong the CR proxies, only education significantly moderated the relationship between Aβ deposition and CERAD-TS. Education, pIQ, and LCA, but not OC, showed moderating effect on the relationship between AD-signature cerebral hypometabolism and CERAD-TS. In contrast, only OC had a significant moderating effect on the relationship between cortical atrophy of the AD-signature regions and CERAD-TS. ConclusionsThe present findings suggest that the proposed CR proxies have different moderating effects on the relationships between specific AD pathologies and cognitive decline. To investigate CR or related issues, it is necessary to select a proper CR proxy considering the target brain pathology.
Dual RNAseq highlights the kinetics of skin microbiome and fish host responsiveness to bacterial infection
Authors: Luyer Jeremy Le , Schull Quentin , Auffret Pauline , Lopez Pierre , Crusot Margaux , Belliard Corinne , Basset Câline , Carradec Quentin , Poulain Julie , Planes Serge , Saulnier Denis 
Published: October 2020

Abstract
Background: Tenacibaculum maritimum is a fish pathogen known for causing serious damage to a broad range of wild and farmed marine fish populations worldwide. The recently sequenced genome of T. maritimum strain NCIMB 2154 T provided unprecedented information on the possible molecular mechanisms involved in the virulence of this species. However, little is known about the dynamic of infection in vivo, and information is lacking on both the intrinsic host response (gene expression) and its associated microbiome community. Here, we applied complementary omic approaches, including dual RNAseq and 16S rRNA gene metabarcoding sequencing using Nanopore and short-read Illumina technologies to unravel the host–pathogen interplay in an experimental infection system using the tropical fish Platax orbicularis as model. Results: We showed that the T. maritimum transcriptomic landscape during infection is characterised by an enhancement of antibiotic catalytic and glucan catalytic functions but a decrease in the sulfate assimilation process, compared with in vitro cultures. The fish host concurrently displays a large panel of immune effectors, notably involving innate response and triggering acute inflammatory response. In addition, our results suggest that fish activate an adaptive immune response visible through the stimulation of T-helper cells, Th17, with congruent reduction of Th2 and T-regulatory cells. Fish were, however, largely sensitive to infection, and less than 25% survived after 96 hpi. These surviving fish showed no evidence of stress (cortisol levels) or significant difference in microbiome diversity compared with controls at the same sampling time. The presence of Tenacibaculum in resistant fish skin and the total absence of any skin lesions suggest that these fish did not escape contact with the pathogen, but rather that they prevented pathogen entry. In these individuals, we detected up-regulation of specific immune-related genes differentiating resistant individuals from controls at 96 hpi, which suggests a possible genomic basis of resistance, although no genetic variation in coding regions were found. Conclusions: Here we focus in detail on the interplay between common fish pathogens and host immune response during experimental infection. We further highlight key actors of defence response, pathogenicity and possible genomic bases of fish resistance to T. maritimum .
Robotic Versus Laparoscopic Gastrectomy for Gastric Cancer: A Systematic Review and Meta-Analysis
Authors: Ma Jianglei , Li Xiaoyao , Zhao Shifu , Zhang Ruifu , Yang Dejun 
Published: October 2020

Abstract
Background To date, robotic surgery has been widely used worldwide. We conducted a systematic review and meta-analysis to evaluate short- and long-term outcomes of robotic gastrectomy (RG) in gastric cancer patients to determine whether RG can replace laparoscopic gastrectomy (LG).Methods Pubmed, Cochrane Library, WanFang, China National Knowledge Infrastructure (CNKI) and VIP databases were comprehensively searched for studies published before May 2020 that compared RG with LG. Next, two independent reviewers conducted literature screening and data extraction. The quality of the literature was assessed using the Newcastle-Ottawa Scale (NOS),and the data analyzed using the Review Manager 5.3 software. Random effects or fixed effects models were applied according to heterogeneity.Results A total of 19 studies including 7275 patients were included in the meta-analyses, of which 4598 patients were in the LG group and 2677 in the RG group. Compared with LG,RG was associated with longer operative time (WMD=−32.96 min; 95% CI:-42.08~-23.84, P<0.00001),less blood loss (WMD=28.66 ml; 95% CI: 18.59~38.73, P<0.00001),and shorter time to first flatus (WMD=0.16days; 95%CI:0.06~0.27, P=0.003).There was no significant difference between RG and LG in terms of the hospital stay (WMD=0.23days, 95 % CI:-0.53~0.98, P=0.56),overall postoperative complication (OR=1.07, 95 % CI:0.91~1.25, P=0.43),mortality (OR=0.67, 95% CI=0.24~1.90, P=0.45),the number of harvested lymph nodes (WMD=-0.96, 95% CI:-2.12~0.20, P=0.10),proximal resection margin (WMD=-0.10 cm,95% CI:-0.29~0.09, P=0.30),and distal resection margin (WMD=0.15cm,95% CI:-0.21~0.52, P=0.41).No significant differences were found between the two treatments in overall survival(OS) (HR=0.95, 95% CI:0.76~1.18; P=0.64), recurrence-free survival(RFS) (HR=0.91, 95% CI:0.69~1.21;P=0.53), and recurrence rate (OR=0.90, 95% CI:0.67~1.21; P=0.50). Conclusions The results of this study suggested that RG is as acceptable as LG in terms of short-term and long-term outcomes. RG can be performed as effectively and safely as LG. Moreover, more randomized controlled trials comparing the two techniques with rigorous study designs are still essential to evaluate the value of the robotic surgery for gastric cancer.
Radiomics Nomograms for Predicting Different Patterns of Distant Metastases After Definitive Chemoradiotherapy for Locally Advanced Non-Small-Cell Lung Cancer
Authors: Tong Xin , Chen Xia , Chen Yicong , Qiu Qingtao , Sun Xiaorong , Xing Ligang 
Published: October 2020

Abstract
Background: To develop and validate radiomics-based nomograms for predicting different patterns of distant metastases (DMs), including oligometastases and polymetastases, after definitive chemoradiotherapy (CRT) for locally advanced non-small-cell lung cancer (LA-NSCLC).Methods: In all, 139 LA-NSCLC patients treated with definitive CRT between January 2014 and December 2017 were analyzed retrospectively. Computed tomography (CT) radiomics features were quantitatively extracted by 3D Slicer software. The least absolute shrinkage and selection operator (LASSO) Cox regression model was applied for date dimension reduction, feature selection and radiomics signature development. Univariate and multivariate Cox regression analyses were utilized to identify independent predictors of DMs. Finally, a nomogram that incorporates both the radiomics signature and independent clinical risk factors was developed and assessed according to the Harrell concordance index (C-index), calibration curve and clinical usefulness.Results: With a median follow-up of 20.6 months, DMs were detected by follow-up imaging in 47 patients (26 patients had oligometastatic disease). For those who experienced DM, the first metastases were most common in the lung (32.1%), followed by the brain (20.7%), and bone (15.1%). The median time to DMs was 13.5 months. Twelve radiomics features were found to be predictive for DMs. Multivariate Cox proportional hazards testing revealed that histology subtype and overall stage were independent clinical risk factors for DMs (p-value < 0.05). The radiomics nomogram combining the selected radiomics signature, histology subtype and overall stage predicted DMs better than either the radiomics signature or clinical factors alone (p-value < 0.001). The model showed good discrimination and good calibration. Furthermore, the radiomics signature consisting of nine selected features was significantly associated with oligometastases (p-value < 0.001). The radiomics-based nomogram showed strong discrimination ability for the prediction of oligometastatic disease. The C-index was 0.800 (95% CI= 0.710 to 0.890) for the primary cohort, and 0.828 (95% CI= 0.686 to 0.970) for the validation cohort.Conclusion: The above-described radiomics nomograms can precisely predict DM and the oligometastatic state in patients with LA-NSCLC, which may constitute a useful clinical tool to guide subsequent personalized treatments.
Structural decomposition analysis with disaggregate factors within the Leontief inverse
Authors: Muradov Kirill 
Published: October 2020

Abstract
A trivial case in input-output structural decomposition analysis is a decomposition of a product of variables, or factors, where one factor is an inverse -- typically Leontief inverse -- of a sum of other factors. There may be dozens and hundreds of such factors that describe the changes in subsets of technical coefficients. The existing literature offers ambiguous guidance in this case. The solution that is consistent with the index number theory may be virtually infeasible. The simplified ad hoc solutions require the researcher to make arbitrary choices, lead to biased estimates and do not ensure the consistency-in-aggregation of factors. This paper reviews the ad hoc solutions to the said problem and describes a numerical test to identify the best-performing solution. It is found that calculating the average of the two polar decomposition forms for each factor is superior to other approximations in terms of minimising the errors.
Combined Topical and Systemic Administration with human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes markedly promoted cutaneous wound healing and regeneration
Authors: Zhou Yang , Zhao Bo , Zhang Liao Xing , Lu Jun Yi , Lu Tao Shou , Cheng Jian , Fu Yu , Lin Lin , Zhang Yan Ning , Li Xin Pei , Zhang Jing , Zhang Jun 
Published: October 2020

Abstract
Background: Cutaneous wound healing and regeneration has become a recognized health challenge in the world, which causes severe damage to the mental and physical health of patients. Human Adipose-derived mesenchymal stem cells (hADSC) play an essential role in wound healing via their paracrine function. Exosomes secreted by hADSC may contribute to this progress. In this study, we investigated the potential clinical application roles of hADSC and hADSC-derived exosomes (hADSC-Exo) in cutaneous wound healing. Methods: hADSC-Exo was isolated from human hADSC by ultracentrifugation. Mice were subjected to a full-thickness skin biopsy experiment and treated with either control vehicle or hADSC or hADSC-Exo by smearing administration (sm) or subcutaneous administration (sc) or intravenous administration (iv). The efficacy of hADSC and hADSC-Exo on wound healing was evaluated by measuring wound closure rates, histological analysis. Results: Combined application of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration offered the additional benefit of promoting wound healing, accelerating re-epithelialization, reducing scar widths, and enhancing angiogenesis and collagen synthesis. Either topical application of hADSC-Exo or systemic administration with hADSC/hADSC-Exo appeared more effective in stimulating cell proliferation, inhibiting cell apoptosis and inflammation, promoting skin elasticity and barrier integrity, with increased genes expression of PCNA, VEGF, collagen III, Filaggrin, Loricrin, and AQP3, with decreased genes expression of TNF-alpha. Conclusion: Our findings suggest that the combined administration of hADSC/hADSC-Exo can facilitate cutaneous wound healing and reduce scar formation. These data provide the first evidence for the feasibility of smearing of hADSC-Exo as a cell-free therapy in treating cutaneous wounds, and the potential clinical value of combined administration of hADSC/hADSC-Exo.