bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysing quantized resistance behaviour in graphene Corbino p-n junction devices
Authors: Liu Chieh-I , Scaletta Dominick S , Patel Dinesh K , Kruskopf Mattias , Levy Antonio , Hill Heather M , Rigosi Albert F 
Published: March 2020

Abstract
Just a few of the promising applications of graphene Corbino pnJ devices include two-dimensional Dirac fermion microscopes, custom programmable quantized resistors, and mesoscopic valley filters. In some cases, device scalability is crucial, as seen in fields like resistance metrology, where graphene devices are required to accommodate currents of the order 100 μA to be compatible with existing infrastructure. However, fabrication of these devices still poses many difficulties. In this work, unusual quantized resistances are observed in epitaxial graphene Corbino p-n junction devices held at the

ν
=
2

plateau (

R

H

≈

12906

Ω

) and agree with numerical simulations performed with the LTspice circuit simulator. The formulae describing experimental and simulated data are empirically derived for generalized placement of up to three current terminals and accurately reflect observed partial edge channel cancellation. These results support the use of ultraviolet lithography as a way to scale up graphene-based devices with suitably narrow junctions that could be applied in a variety of subfields.
Using chaotic advection for facile high-throughput fabrication of ordered multilayer micro- and nanostructures: continuous chaotic printing
Authors: Chávez-Madero Carolina , de León-Derby María Díaz , Samandari Mohamadmahdi , Ceballos-González Carlos Fernando , Bolívar-Monsalve Edna Johana , Mendoza-Buenrostro Christian , Holmberg Sunshine , Garza-Flores Norma Alicia , Almajhadi Mohammad Ali , González-Gamboa Ivonne , Yee-de León Juan Felipe , Martínez-Chapa Sergio O. , Rodríguez Ciro A. , Wickramasinghe Hemantha Kumar , Madou Marc , Dean David , Khademhosseini Ali , Zhang Yu Shrike , Alvarez Mario Moisés , Trujillo-de Santiago Grissel 
Published: March 2020

Abstract
This paper introduces the concept of continuous chaotic printing, i.e. the use of chaotic flows for deterministic and continuous extrusion of fibers with internal multilayered micro- or nanostructures. Two free-flowing materials are coextruded through a printhead containing a miniaturized Kenics static mixer (KSM) composed of multiple helicoidal elements. This produces a fiber with a well-defined internal multilayer microarchitecture at high-throughput (>1.0 m min−1). The number of mixing elements and the printhead diameter determine the number and thickness of the internal lamellae, which are generated according to successive bifurcations that yield a vast amount of inter-material surface area (∼102 cm2 cm−3) at high resolution (∼10 µm). This creates structures with extremely high surface area to volume ratio (SAV). Comparison of experimental and computational results demonstrates that continuous chaotic 3D printing is a robust process with predictable output. In an exciting new development, we demonstrate a method for scaling down these microstructures by 3 orders of magnitude, to the nanoscale level (∼150 nm), by feeding the output of a continuous chaotic 3D printhead into an electrospinner. The simplicity and high resolution of continuous chaotic printing strongly supports its potential use in novel applications, including—but not limited to—bioprinting of multi-scale layered biological structures such as bacterial communities, living tissues composed of organized multiple mammalian cell types, and fabrication of smart multi-material and multilayered constructs for biomedical applications.
Constitutive equation and hot processing map of TA15 titanium alloy
Authors: Ji Hongchao , Peng Zhanshuo , Pei Weichi , Xin Long , Ma Zheng , Lu Yonghao 
Published: March 2020

Abstract
The stress-strain curves of TA15 titanium alloy at 750 ∼ 950 °C and 0.001 ∼ 1 s−1 were obtained by hot compression with Gleeble-1500D. Based on the compression experimental data of TA15 titanium alloy, the Johnson-Cook high temperature thermal deformation constitutive equation was established. By calculating the constitutive equation, the flow stress was compared with the measured stress-strain curve, and the accuracy of the equation was verified. Then, based on the theory of hot processing map of dynamic materials, the hot processing map is drawn when the strain is 0.1, 0.2, 0.3, 0.4, 0.5 and 0.6. The reasonable range of hot processing map of TA15 titanium alloy was determined. When the temperature is between 750 °C–875 °C, the power dissipation factor decreases with increasing strain rate. The maximum power dissipation is distributed between 825 °C–950 °C. This indicates that recrystallization occurred within this range. The safe zone is mainly concentrated in the temperature range of 885 °C–950 °C, the strain rate is less than 0.1 s−1. It can be seen that instability does not occur in the high temperature and low strain region. Therefore, at 885 ≤ T ≤ 950 °C, 0.001 ≤

ε
̇

≤ 0.1 s−1 or 800 ≤ T ≤ 875 °C, 0.001 ≤

ε
̇

≤ 0.002 s−1, it is reasonable to perform high temperature deformation on TA15 titanium alloy.
Composition design of 7XXX aluminum alloys optimizing stress corrosion cracking resistance using machine learning
Authors: Xinyu Cao , Yingbo Zhang , Jiaheng Li , Hui Chen 
Published: March 2020

Abstract
In this paper, three different strategies based on machine learning methods were applied to Al-Zn-Mg-Cu series alloy composition design with the targeted property of stress corrosion cracking (SCC) resistance. By comparing the results of the strategies, it was discovered that the performance of the efficient global optimization (EGO) method was better than that of response surface optimization method, and much better than that of Random method, among which the Al-6.05Zn-1.46Mg-1.32Cu-0.13Zr-0.02Ti-0.50Y-0.23Ce (named EGO alloy) alloy had the best stress corrosion cracking resistance. The slow strain rate test (SSRT) technique was carried out to compare the EGO alloy with the traditional 7N01 alloy. It indicated that the ISCC of the new EGO alloy was lower than that of traditional 7N01 alloy for both single and double aging treatment. With the XRD, SEM and EDS analysis, it was found the rare earth elements formed Al8Cu4(Y, Ce) and quadrilateral phase Al20Ti2(Y, Ce) in the EGO alloy.
Diversity in complex systems: measuring parts of the distribution to the whole
Authors: Rajaram R , Castellani B 
Published: March 2020

Abstract
Despite the utility of the Hill numbers, measuring diversity within complex systems and complex datasets, particularly regarding parts of a distribution to the whole—that is, different portions of diversity types to the entire system or dataset—is a challenging issue. In this paper, we attempt to relate the diversity of a part (or parts) of a distribution to the diversity of the whole. We derive this relationship for the Hill numbers

q

D

, and use these results to further examine the effect of a freely varying type on the diversity of the whole distribution.
The Unique and Interactive Effects of Patient Race, Patient Socioeconomic Status, and Provider Attitudes on Chronic Pain Care Decisions
Authors: Anastas Tracy M , Miller Megan M , Hollingshead Nicole A , Stewart Jesse C , Rand Kevin L , Hirsh Adam T 
Published: March 2020

AbstractBackgroundCompared to White and high socioeconomic status (SES) patients, Black and low SES patients receive less adequate pain care. Providers may contribute to these disparities by making biased decisions that are driven, in part, by their attitudes about race and SES.PurposeWe examined the effects of patient race and SES on providers’ chronic pain decisions and the extent to which providers’ implicit and explicit attitudes about race and SES were related to these decisions.MethodsPhysician residents/fellows (n = 436) made pain care decisions for 12 computer-simulated patients with chronic back pain that varied by race (Black/White) and SES (low/high). Physicians also completed measures assessing implicit and explicit attitudes about race and SES.ResultsThere were three significant race-by-SES interactions: (a) For high SES patients, Black (vs. White) patients were rated as having more pain interference; the opposite race difference emerged for low SES patients. (b) For high SES patients, Black (vs. White) patients were rated as being in greater distress; no race difference emerged for low SES patients. (c) For low SES patients, White (vs. Black) patients were more likely to be recommended workplace accommodations; no race difference emerged for high SES patients. Additionally, providers were more likely to recommend opioids to Black (vs. White) and low (vs. high) SES patients, and were more likely to use opioid contracts with low (vs. high) SES patients. Providers’ implicit and explicit attitudes predicted some, but not all, of their pain-related ratings.ConclusionThese results highlight the need to further examine the effects of patient race and SES simultaneously in the context of pain care.
T-Gene: improved target gene prediction
Authors: O’Connor Timothy , Grant Charles E , Bodén Mikael , Bailey Timothy L 
Published: March 2020

Abstract

Motivation
Identifying the genes regulated by a given transcription factor (TF) (its ‘target genes’) is a key step in developing a comprehensive understanding of gene regulation. Previously, we developed a method (CisMapper) for predicting the target genes of a TF based solely on the correlation between a histone modification at the TF’s binding site and the expression of the gene across a set of tissues or cell lines. That approach is limited to organisms for which extensive histone and expression data are available, and does not explicitly incorporate the genomic distance between the TF and the gene.

Results
We present the T-Gene algorithm, which overcomes these limitations. It can be used to predict which genes are most likely to be regulated by a TF, and which of the TF’s binding sites are most likely involved in regulating particular genes. T-Gene calculates a novel score that combines distance and histone/expression correlation, and we show that this score accurately predicts when a regulatory element bound by a TF is in contact with a gene’s promoter, achieving median precision above 60%. T-Gene is easy to use via its web server or as a command-line tool, and can also make accurate predictions (median precision above 40%) based on distance alone when extensive histone/expression data is not available for the organism. T-Gene provides an estimate of the statistical significance of each of its predictions.

Availability and implementation
The T-Gene web server, source code, histone/expression data and genome annotation files are provided at http://meme-suite.org.

Supplementary information
Supplementary data are available at Bioinformatics online.
Implantation, orientation and validation of a commercially produced heart-rate logger for use in a perciform teleost fish
Authors: Muller Cuen , Childs Amber-Robyn , Duncan Murray I , Skeeles Michael R , James Nicola C , van der Walt Kerry-Ann , Winkler Alexander C , Potts Warren M 
Published: March 2020

AbstractQuantifying how the heart rate of ectothermic organisms responds to environmental conditions (e.g. water temperature) is important information to quantify their sensitivity to environmental change. Heart rate studies have typically been conducted in lab environments where fish are confined. However, commercially available implantable heart rate biologgers provide the opportunity to study free-swimming fish. Our study aimed to determine the applicability of an implantable device, typically used on fusiform-shaped fish (e.g. salmonids), for a perciform fish where morphology and anatomy prevent ventral incisions normally used on fusiform-shaped fish. We found that ventrolateral incisions allowed placement near the heart, but efficacy of the loggers was sensitive to their orientation and the positioning of the electrodes. Electrocardiogram detection, signal strength and subsequent heart rate readings were strongly influenced by logger orientation with a significant effect on the quality and quantity of heart rate recordings. We provide details on the surgical procedures and orientation to guide future heart rate biologger studies on perciform-shaped fish.
Arrhythmogenic cardiomyopathy: pathogenesis, pro-arrhythmic remodelling, and novel approaches for risk stratification and therapy
Authors: van der Voorn Stephanie M , te Riele Anneline S J M , Basso Cristina , Calkins Hugh , Remme Carol Ann , van Veen Toon A B 
Published: March 2020

AbstractArrhythmogenic cardiomyopathy (ACM) is a life-threatening cardiac disease caused by mutations in genes predominantly encoding for desmosomal proteins that lead to alterations in the molecular composition of the intercalated disc. ACM is characterized by progressive replacement of cardiomyocytes by fibrofatty tissue, ventricular dilatation, cardiac dysfunction, and heart failure but mostly dominated by the occurrence of life-threatening arrhythmias and sudden cardiac death (SCD). As SCD appears mostly in apparently healthy young individuals, there is a demand for better risk stratification of suspected ACM mutation carriers. Moreover, disease severity, progression, and outcome are highly variable in patients with ACM. In this review, we discuss the aetiology of ACM with a focus on pro-arrhythmic disease mechanisms in the early concealed phase of the disease. We summarize potential new biomarkers which might be useful for risk stratification and prediction of disease course. Finally, we explore novel therapeutic strategies to prevent arrhythmias and SCD in the early stages of ACM.
Landscape Ecology of Rhipicephalus (Boophilus) microplus (Ixodida: Ixodidae) Outbreaks in the South Texas Coastal Plain Wildlife Corridor Including Man-Made Barriers
Authors: Showler Allan T , Pérez de León Adalberto 
Published: March 2020

Abstract
Landscape features and the ecology of suitable hosts influence the phenology of invasive tick species. The southern cattle fever tick, Rhipicephalus (Boophilus) microplus (Canestrini) (Ixodida: Ixodidae), vectors causal agents of babesiosis in cattle and it infests exotic, feral nilgai, Bosephalus tragocamelus Pallas, and indigenous white-tailed deer, Odocoilus virginianus (Zimmerman), on the South Texas coastal plain wildlife corridor. The corridor extends from the Mexico border to cattle ranches extending north from inside Willacy Co. Outbreaks of R. microplus infesting cattle and nondomesticated ungulate hosts since 2014 in the wildlife corridor have focused attention on host infestation management and, by extension, dispersal. However, there is a knowledge gap on the ecology of R. microplus outbreaks in the South Texas coastal plain wildlife corridor. Ixodid distribution on the wildlife corridor is strongly influenced by habitat salinity. Saline habitats, which constitute ≈25% of the wildlife corridor, harbor few ixodids because of occasional salt toxicity from hypersaline wind tides and infrequent storm surges, and from efficient egg predation by mud flat fiddler crabs, Uca rapax (Smith). Rhipicephalus microplus infestations on nilgai were more prevalent in part of the corridor with mixed low salinity and saline areas than in an area that is more extensively saline. The different levels of R. microplus infestation suggest that man-made barriers have created isolated areas where the ecology of R. microplus outbreaks involve infested nilgai. The possible utility of man-made barriers for R. microplus eradication in the lower part of the South Texas coastal plain wildlife corridor is discussed.
Mapping the patchy legislative landscape of non-native tree species in Europe
Authors: Pötzelsberger Elisabeth , Lapin Katharina , Brundu Giuseppe , Adriaens Tim , Andonovski Vlatko , Andrašev Siniša , Bastien Jean-Charles , Brus Robert , Čurović Milić , Čurović Željka , Cvjetković Branislav , Đodan Martina , Domingo-Santos Juan M , Gazda Anna , Henin Jean-Marc , Hernea Cornelia , Karlsson Bo , Keča Ljiljana , Keren Srđan , Keserű Zsolt , Konstantara Thomai , Kroon Johan , La Porta Nicola , Lavnyy Vasyl , Lazdina Dagnija , Lukjanova Aljona , Maaten Tiit , Madsen Palle , Mandjukovski Dejan , Marín Pageo Francisco J , Marozas Vitas , Martinik Antonin , Mason William L , Mohren Frits , Monteverdi Maria Cristina , Neophytou Charalambos , Neville Pat , Nicolescu Valeriu-Norocel , Nygaard Per Holm , Orazio Christophe , Parpan Taras , Perić Sanja , Petkova Krasimira , Popov Emil Borissov , Power Mick , Rédei Károly , Rousi Matti , Silva Joaquim S , Sivacioğlu Ahmet , Socratous Michalis , Straigytė Lina , Urban Josef , Vandekerkhove Kris , Wąsik Radosław , Westergren Marjana , Wohlgemuth Thomas , Ylioja Tiina , Hasenauer Hubert 
Published: March 2020

AbstractEurope has a history rich in examples of successful and problematic introductions of trees with a native origin outside of Europe (non-native trees, NNT). Many international legal frameworks such as treaties and conventions and also the European Union have responded to the global concern about potential negative impacts of NNT that may become invasive in natural ecosystems. It is, however, national and regional legislation in particular that affects current and future management decisions in the forest sector and shapes the landscapes of Europe. We identified all relevant legal instruments regulating NNT, the different legal approaches and the regulatory intensity in 40 European countries (no microstates). Information on hard and effective soft law instruments were collected by means of a targeted questionnaire and consultation of international and national legislation information systems and databases. In total, 335 relevant legal instruments were in place in June/July 2019 to regulate the use of NNT in the investigated 116 geopolitical legal units (countries as well as sub-national regions with their own legislation). Countries and regions were empirically categorized according to ad hoc-defined legislation indicators. These indicators pay respect to the general bans on the introduction of non-native species, the generally allowed and prohibited NNT, approval mechanisms and specific areas or cases where NNT are restricted or prohibited. Our study revealed a very diverse landscape of legal frameworks across Europe, with a large variety of approaches to regulating NNT being pursued and the intensity of restriction ranging from very few restrictions on species choice and plantation surface area to the complete banning of NNT from forests. The main conclusion is that there is a clear need for more co-ordinated, science-based policies both at the local and international levels to enhance the advantages of NNT and mitigate potential negative effects.
The Meaningful Participation of Refugees in Decision-Making Processes: Questions of Law and Policy
Authors: Harley Tristan , Hobbs Harry 
Published: March 2020

Abstract
There has been a significant push in recent years for greater and more meaningful participation of refugees in decision-making processes that affect them. This push is identifiable in a range of international instruments, including the 2016 New York Declaration for Refugees and Migrants and the 2018 Global Compact on Refugees, as well as numerous initiatives developed by refugees, civil society organizations, and international organizations at the local, national, and international level. This article considers the emergent drive for refugee participation from the perspective of both law and policy. It examines the evolution of the international legal framework, analysing the extent to which international refugee and human rights law mandate the inclusion of refugees in decisions that affect them. The article also explores the notion of participation in detail, teasing out several key challenges for consideration in the development of inclusive participatory processes. Drawing this material together, it explores two options that could further promote the moral, political, and ultimately legal authority for meaningfully including refugees in the design and implementation of policy. These options are indicators that establish baselines and track refugee participation in decision-making processes, and a new, non-binding United Nations declaration that clearly details the right of refugees to have some authority in decision-making processes that affect them.
National Public Health Burden Estimates of Endocarditis and Skin and Soft-Tissue Infections Related to Injection Drug Use: A Review
Authors: See Isaac , Gokhale Runa H , Geller Andrew , Lovegrove Maribeth , Schranz Asher , Fleischauer Aaron , McCarthy Natalie , Baggs James , Fiore Anthony 
Published: March 2020

Abstract

Background
Despite concerns about the burden of the bacterial and fungal infection syndromes related to injection drug use (IDU), robust estimates of the public health burden of these conditions are lacking. The current article reviews and compares data sources and national burden estimates for infective endocarditis (IE) and skin and soft-tissue infections related to IDU in the United States.

Methods
A literature review was conducted for estimates of skin and soft-tissue infection and endocarditis disease burden with related IDU or substance use disorder terms since 2011. A range of the burden is presented, based on different methods of obtaining national projections from available data sources or published data.

Results
Estimates using available data suggest the number of hospital admissions for IE related to IDU ranged from 2900 admissions in 2013 to more than 20 000 in 2017. The only source of data available to estimate the annual number of hospitalizations and emergency department visits for skin and soft-tissue infections related to IDU yielded a crude estimate of 98 000 such visits. Including people who are not hospitalized, a crude calculation suggests that 155 000–540 000 skin infections related to IDU occur annually.

Discussion
These estimates carry significant limitations. However, regardless of the source or method, the burden of disease appears substantial, with estimates of thousands of episodes of IE among persons with IDU and at least 100 000 persons who inject drugs (PWID) with skin and soft-tissue infections annually in the United States. Given the importance of these types of infections, more robust and reliable estimates are needed to better quantitate the occurrence and understand the impact of interventions.
Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies
Authors: Cao Lei , Xia Xianyou , Kong Yu , Jia Fengqin , Yuan Bo , Li Rui , Li Qian , Wang Yuxin , Cui Mingrui , Dai Zhongye , Zheng Huimin , Christensen Jesper , Zhou Yuan , Wu Xudong 
Published: March 2020

AbstractMutations of epigenetic regulators are pervasive in human tumors. ASXL1 is frequently mutated in myeloid malignancies. We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A (H2AK119ub1), a Polycomb repressive mark. However, a complete mechanistic understanding of ASXL1 in transcriptional regulation and tumor suppression remains to be defined. Here, we find that depletion of Asxl1 confers murine 32D cells to IL3-independent growth at least partly due to sustained activation of PI3K/AKT signaling. Consistently, Asxl1 is critical for the transcriptional activation of Pten, a key negative regulator of AKT activity. Then we confirm that Asxl1 is specifically enriched and required for H2AK119 deubiquitylation at the Pten promoter. Interestingly, ASXL1 and PTEN expression levels are positively correlated in human blood cells and ASXL1 mutations are associated with lower expression levels of PTEN in human myeloid malignancies. Furthermore, malignant cells with ASXL1 downregulation or mutations exhibit higher sensitivity to the AKT inhibitor MK2206. Collectively, this study has linked the PTEN/AKT signaling axis to deregulated epigenetic changes in myeloid malignancies. It also provides a rationale for mechanism-based therapy for patients with ASXL1 mutations.