bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interlaboratory comparison of humic substances compositional space as measured by Fourier transform ion cyclotron resonance mass spectrometry (IUPAC Technical Report)
Authors: Zherebker Alexander , Kim Sunghwan , Schmitt-Kopplin Philippe , Spencer Robert G. M. , Lechtenfeld Oliver , Podgorski David C. , Hertkorn Norbert , Harir Mourad , Nurfajin Nissa , Koch Boris , Nikolaev Eugene N. , Shirshin Evgeny A. , Berezin Sergey A. , Kats Dmitry S. , Rukhovich Gleb D. , Perminova Irina V. 
Published: August 2020

Abstract
Interlaboratory comparison on the determination of the molecular composition of humic substances (HS) was undertaken in the framework of IUPAC project 2016-015-2-600. The analysis was conducted using high resolution mass spectrometry, nominally, Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) with electrospray ionization. Six samples of HS from freshwater, soil, and leonardite were used for this study, including one sample of humic acids (HA) from coal (leonardite), two samples of soil HA (the sod-podzolic soil and chernozem), two samples of soil fulvic acids (FA) (the sod-podzolic soil and chernozem), and one sample of freshwater humic acids (the Suwannee River). The samples were analyzed on five different FTICR MS instruments using the routine conditions applied in each participating laboratory. The results were collected as mass lists, which were further assigned formulae for the determination of molecular composition. The similarity of the obtained data was evaluated using appropriate statistical metrics. The results have shown that direct comparison of discrete stoichiometries assigned to the mass lists obtained by the different laboratories yielded poor results with low values of the Jaccard similarity score – not exceeding 0.56 (not more than 56 % of the similar peaks). The least similarity was observed for the aromatics-rich HA samples from leonardite (coal) and the chernozem soil, which might be connected to difficulties in their ionization. The reliable similarity among the data obtained in this intercomparison study was achieved only by transforming a singular point (stoichiometry) in van Krevelen diagram into a sizeable pixel (a number of closely located stoichiometries), which can be calculated from the population density distribution. The conclusion was made that, so far, these are descriptors of occupation density distribution, which provide the metrics compliant with the data quality requirements, such as the reproducibility of the data measurements on different instruments.
Influence of Sodium Alginate on Properties of Tetracalcium Phosphate/Nanomonetite Biocement
Authors: Štulajterová R. , Medvecký L. , Giretová M. , Sopčák T. , Briančin J. 
Published: August 2020

Abstract
The tetracalcium phosphate/nanomonetite (TTCPMH) biocements with the addition of sodium alginate were prepared by mechanical homogenization of powder mixture with hardening liquid containing sodium alginate. The effect of various viscosity of different alginates on properties of TTCPMH cement mixture was investigated. The medium viscous (MED) alginate had a more negative effect on setting process and compressive strength than low viscous (LOW) alginate. An approx. 50% decrease in mechanical properties (compressive strengths, Young´s modulus, work of fracture (WOF)) was revealed after an addition of 0.25 wt % with rapid fall above 1 wt % of LOW alginate in biocement. A statistically significant difference in the WOF was found between of 0.25 and 0.5 LOW alginate biocements (p<0.035) whereas no statistical differences were revealed between WOF of 0.5 and 1 LOW alginate biocements (p˃0.357). In the microstructure of composite cements, the increased amounts of granular or finer needle-like nanohydroxyapatite particles arranged into the form of more separated spherical agglomerates were observed. A low cytotoxicity of cement extracts based on measurement of cell proliferation was revealed.
Additive Manufacturing of Steel and Copper Using Fused Layer Modelling: Material and Process Development
Authors: Ecker J. V. , Dobrezberger K. , Gonzalez-Gutierrez J. , Spoerk M , Gierl-Mayer Ch. , Danninger H. 
Published: August 2020

AbstractFused Layer Modelling (FLM) is one out of several material extrusion (ME) additive manufacturing (AM) methods. FLM usually deals with processing of polymeric materials but can also be used to process metal-filled polymeric systems to produce metallic parts. Using FLM for this purpose helps to save costs since the FLM hardware is cheap compared to e.g. direct metal laser processing hardware, and FLM offers an alternative route to the production of metallic components.To produce metallic parts by FLM, the methodology is different from direct metal processing technologies, and several processing steps are required: First, filaments consisting of a special polymer-metal composition are produced. The filament is then transformed into shaped parts by using FLM process technology. Subsequently the polymeric binder is removed (”debinding”) and finally the metallic powder body is sintered. Depending on the metal powder used, the binder composition, the FLM production parameters and also the debinding and sintering processes must be carefully adapted and optimized.The focal points of this study are as following:1. To confirm that metallic parts can be produced by using FLM plus debinding and sintering as an alternative route to direct metal additive manufacturing.2. Determination of process parameters, depending on the used metal powders (steel and copper) and optimization of each process step.3. Comparison of the production paths for the different metal powders and their debinding and sintering behavior as well as the final properties of the produced parts.The results showed that both materials were printable after adjusting the FLM parameters, metallic parts being produced for both metal powder systems. The production method and the sintering process worked out well for both powders. However there are specific challenges in the sintering process that have to be overcome to produce high quality metal parts. This study serves as a fundamental basis for understanding when it comes to the processing of steel and copper powder into metallic parts using FLM processing technology.
Preparation, Microstructure Evaluation and Performance Analysis of Diamond-Iron Bonded Magnetic Abrasive Powder
Authors: Singh Palwinder , Singh Lakhvir , Singh Sehijpal 
Published: August 2020

AbstractThe customary edged tool for machining is uneconomical for harder and hard to machine materials and furthermore the level of surface finish accomplished is not that great. As of late, a lot of consideration in mechanical engineering has been centered on finishing tasks. Not many investigations have been accounted for till date on the advancement of substitute magnetic abrasive powder (MAP). In this paper, to improve the finishing performance, the abrasive powder were prepared by mechanical alloying of diamond powder and iron (Fe) powder, compacting these with universal testing machine (UTM) and then sintered at different temperature in a sintering machine in an inert gas (H2) atmosphere. These compacts were crushed and sieved to obtain various sizes of MAP. This abrasive powder were micro-structurally examined. The results indicate that the densification increases and porosity decreases with increasing temperature. Moreover, the prepared bonded MAP has potential performance as a new MAP for fine finishing in Magnetic Abrasive Flow Machining (MAFM) process.
An actuarial mathematical model for a new pension philosophy. An application to the accountant pension fund
Authors: Attias Anna , Ciavalini Simona , Morrone Carla , Saitta Daniela 
Published: August 2020

Abstract
This paper adapts an actuarial mathematical model, built for the Italian public pension system, based on the law proposal 3035/2009 to the Accountant Pension Fund (CNPADC). The aim is to introduce a new philosophy pension highly correlated with the concept of adequacy for an ambitious social welfare; using the logic of the 3035/2009 proposal, which guarantees a minimum threshold for the replacement rate of the direct pension, this study provides a rigorous actuarial mathematical model that explains a sort of rate of contribution at a tendential equilibrium, in a pay-as-you-go pension system. This model reveals for which parameters it is possible to intervene to maintain the standard of living in retirement.
Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease
Authors: Huang He , Camats-Perna Judith , Medeiros Rodrigo , Anggono Victor , Widagdo Jocelyn 
Published: August 2020

AbstractCognitive impairment in Alzheimer’s disease (AD) is associated with dysregulation of the RNA and protein expression profiles in the brain. Recent studies have highlighted the importance of RNA post-transcriptional regulation (epitranscriptomics) in higher order brain functions. Specifically,N6-methyladenosine (m6A), which controls RNA stability, splicing, translation and trafficking, plays an important role in learning and memory. This raises the question of whether m6A signaling is perturbed in AD. To address this, we investigated the expression profile of known m6A-regulatory genes using a public RNA-seq dataset and identified a subset of genes which were significantly dysregulated in the human AD brain. Among these, genes encoding the m6A methyltransferase,METTL3, and a member of the m6A methyltransferase complex (MACOM),RBM15B, were downregulated and upregulated in the hippocampus, respectively. These findings were validated at the protein level using an independent cohort of postmortem human brain samples. Unexpectedly, we observed an accumulation of methyltransferase-like 3 (METTL3), but not RBM15B, in the insoluble fractions, which positively correlated with the levels of insoluble Tau protein in the postmortem human AD samples. Aberrant expression and distribution of METTL3 in the hippocampus of the AD brain may therefore represent an epitranscriptomic mechanism underlying the altered gene expression patterns associated with disease pathogenesis.
The effect of strength training with different frequency on untrained university students
Authors: Cigerci Ali E. , Genc Harun 
Published: August 2020

Background and Study Aim: The target of this paper was to examine the effects of strength training with different frequency on physical, performance and strength features on untrained university male students.
Material and Methods: 24 subjects (age= 21.47+1.50) were divided into three groups; 8 for strength training group once a week (ST1), 8 for strength training group three times a week (ST3) and 8 for control group (CG). The training groups were applied a 6-week ST that lasted approximately 80-90 minutes for each training 3 days a week for ST3 and once a week for ST1. Analysis of intergroup, intragroup and the effect of training were carried out with repeated measures ANOVA. Significance was set at 0.05.
Results: There was no difference in body weight and body mass index values in training groups, while a significant increase was found in CG. In addition, there was a significant decrease in body fat percentage and a significant increase in skeleton muscle mass without any change in body weight and body mass index in ST3. No statistical difference was seen in 10-20 m sprint and agility tests in all groups. For vertical jump, balance test for right and left leg, there was a significant difference between the pre and post-test measurements of ST1 and ST3. In standing long jump measurements, significance was seen in favor of ST3. In strength parameter, while a significant difference was detected in bench press, shoulder press and push-up due to the development of training groups, a statistically significance was found in squat and biceps curl by reason of improvement in ST3.
Conclusion: As a conclusion, it can be said that 6-week strength training with different frequency applied on untrained male students has a positive effect on physical, performance and strength features.
Reverse Total Shoulder Arthroplasty with a Superior Augmented Glenoid Component for Favard Type-E1, E2, and E3 Glenoids
Authors: Liuzza Lindsey , Mai David H. , Grey Sean , Wright Thomas W. , Flurin Pierre-Henri , Roche Christopher P. , Zuckerman Joseph D. , Virk Mandeep S. 
Published: August 2020

Background:Uncorrected superior glenoid wear in patients managed with reverse total shoulder arthroplasty (rTSA) can result in increased complications, including baseplate failure. The present study quantifies the clinical and radiographic outcomes of patients with Favard type-E1, E2, and E3 glenoid deformity who were managed with rTSA with use of a superior or superior/posterior augmented glenoid baseplate.Methods:We retrospectively reviewed the records for 68 patients with shoulder arthritis and Favard type-E1, E2, or E3 glenoid deformity who were managed with primary rTSA and a 10° superior augmented or 10° superior/8° posterior augmented baseplate. The mean duration of follow-up was 40 months (range, 24 to 85 months). Outcomes were assessed preoperatively and at the latest follow-up with shoulder range of motion and use of outcome scores including the Simple Shoulder Test (SST), University of California Los Angeles (UCLA) score, American Shoulder and Elbow Surgeons (ASES) score, Constant score, and Shoulder Pain and Disability Index (SPADI) score. Radiographs were evaluated preoperatively and at the time of the latest follow-up. Differences in preoperative and postoperative range of motion and outcome metrics were assessed with use of a 2-tailed Student t test.Results:The majority of patients experienced clinically meaningful improvements in terms of pain and function following rTSA with a superior or superior/posterior augment, with 94% of patients rating themselves as “much better” (73.5%) or “better” (20.5%) at the time of the latest follow-up. At least 88% of the patients exceeded the minimum clinically important difference (MCID) threshold, and 75% of patients exceeded the substantial clinical benefit (SCB) threshold, for each of the clinical outcome metrics and range of motion. Five complications were reported (prevalence, 7.4%), including acromial stress fracture (2 patients), posttraumatic scapular neck fracture (1 patient), chronic shoulder pain (1 patient), and aseptic glenoid loosening (1 patient).Conclusions:The present short-term clinical and radiographic study demonstrated that shoulder arthropathy with superior glenoid wear patterns (Favard types E1, E2, and E3) can be successfully treated with rTSA with a superior or superior/posterior augmented baseplate. Longer-term clinical and radiographic follow-up is necessary to confirm that these promising short-term results are durable.Level of Evidence:TherapeuticLevel IV. See Instructions for Authors for a complete description of levels of evidence.
Surgical Outcome and Oncological Survival of Osteofibrous Dysplasia-Like and Classic Adamantinomas
Authors: Schutgens E.M. , Picci P. , Baumhoer D. , Pollock R. , Bovée J.V.M.G. , Hogendoorn P.C.W. , Dijkstra P.D.S. , Rueten-Budde A.J. , Jutte P.C. , Traub F. , Leithner A. , Tunn P.-U. , Funovics P. , Sys G. , San-Julian M. , Schaap G.R. , Dürr H.R. , Hardes J. , Healey J. , Capanna R. , Biau D. , Gomez-Brouchet A. , Wunder J. , Cosker T.D.A. , Laitinen M.K. , Niu X. , Kostiuk V. , van de Sande M.A.J. ,   Adamantinoma Research Group
Published: August 2020

Background:
Osteofibrous dysplasia-like adamantinoma (OFD-AD) and classic adamantinoma (AD) are rare, neoplastic diseases with only limited data supporting current treatment protocols. We believe that our retrospective multicenter cohort study is the largest analysis of patients with adamantinoma to date. The primary purpose of this study was to describe the disease characteristics and evaluate the oncological outcomes. The secondary purpose was to identify risk factors for local recurrence after surgical treatment and propose treatment guidelines.

Methods:
Three hundred and eighteen confirmed cases of OFD-AD and AD for which primary treatment was carried out between 1985 and 2015 were submitted by 22 tertiary bone tumor centers. Proposed clinical risk factors for local recurrence such as size, type, and margins were analyzed using univariable and multivariate Cox regression analysis.

Results:
Of the 318 cases, 128 were OFD-AD and 190 were AD. The mean age at diagnosis was 17 years (median, 14.5 years) for OFD-AD and 32 years (median, 28 years) for AD; 53% of the patients were female. The mean tumor size in the OFD-AD and AD groups combined was 7.8 cm, measured histologically. Sixteen percent of the patients sustained a pathological fracture prior to treatment. Local recurrence was recorded in 22% of the OFD-AD cases and 24% of the AD cases. None of the recurrences in the OFD-AD group progressed to AD. Metastatic disease was found in 18% of the AD cases and fatal disease, in 11% of the AD cases. No metastatic or fatal disease was reported in the OFD-AD group. Multivariate Cox regression analysis demonstrated that uncontaminated resection margins (hazard ratio [HR] = 0.164, 95% confidence interval [CI] = 0.092 to 0.290, p < 0.001), pathological fracture (HR = 1.968, 95% CI = 1.076 to 3.600, p = 0.028), and sex (female versus male: HR = 0.535, 95% CI = 0.300 to 0.952, p = 0.033) impacted the risk of local recurrence.

Conclusions:
OFD-AD and AD are parts of a disease spectrum but should be regarded as different entities. Our results support reclassification of OFD-AD into the intermediate locally aggressive category, based on the local recurrence rate of 22% and absence of metastases. In our study, metastatic disease was restricted to the AD group (an 18% rate). We advocate wide resection with uncontaminated margins including bone and involved periosteum for both OFD-AD and AD.

Level of Evidence:
Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Risk Factors for Recurrent Anterior Glenohumeral Instability and Clinical Failure Following Primary Latarjet Procedures
Authors: Di Giacomo Giovanni , Peebles Liam A. , Midtgaard Kaare S. , de Gasperis Nicola , Scarso Paolo , Provencher CPT Matthew T. 
Published: August 2020

Background:
Patients with a greater risk of recurrent instability and inferior clinical outcomes following a primary Latarjet procedure can be preoperatively identified on the basis of clinical, radiographic, and demographic criteria. The purpose of this study was to identify risk factors influencing the rates of recurrent anterior glenohumeral instability and clinical failure following a primary Latarjet procedure.

Methods:
All patients who underwent a primary Latarjet procedure were prospectively enrolled and evaluated. The Western Ontario Shoulder Instability Index (WOSI) and Single Assessment Numeric Evaluation (SANE) outcome scores were collected at a minimum 5-year follow-up along with evidence of recurrent instability. Recurrent instability (recurrent subluxation or dislocation) was considered as a failure. Clinical failure was defined as a postoperative WOSI score of ≥630 points (≤70% normal) or a SANE score of ≤70 points.

Results:
From 2004 to 2014, 344 patients (358 shoulders) with a mean age of 30.6 years (range, 16 to 68 years) were enrolled and had a mean follow-up time of 75 months (range, 61 to 89 months). The median postoperative WOSI score was 265 points (range, 0 to 1,100 points), and the median SANE score was 88 points (range, 50 to 100 points). Recurrence occurred in 17 shoulders (4.7%), 5 with dislocation and 12 with subluxation; and 28 (8.2%) of 341 shoulders without recurrent instability were clinical failures following a Latarjet procedure. The risk factors for recurrence included atraumatic dislocation (odds ratio [OR], 4.6; p < 0.01) and bilateral instability (OR, 4.0; p = 0.01), whereas the risk factors for clinical failure (WOSI score of ≥630 points or SANE score of ≤70 points) were female sex (OR, 2.8; p < 0.01) and bilateral instability (OR, 4.6; p = 0.01).

Conclusions:
Outcomes at a mean of >6 years following a primary Latarjet procedure for anterior shoulder instability were very good, with an overall recurrence rate of 4.7%. An additional 8.2% of cases were defined as clinical failures. Patients with an atraumatic mechanism of primary dislocation, bilateral instability, and female sex were identified to be at a greater risk of recurrence or clinical failure. Although additional work is necessary, patients with capsuloligamentous laxity, relatively atraumatic instability history, bilateral instability, and female sex may be preoperatively identified as having a higher risk of treatment failure after a primary Latarjet procedure.

Level of Evidence:
Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Omitting Routine Radiography of Traumatic Ankle Fractures After Initial 2-Week Follow-up Does Not Affect Outcomes
Authors: van Gerven P. , Krijnen P. , Zuidema W.P. , El Moumni M. , Rubinstein S.M. , van Tulder M.W. , Schipper I.B. , Termaat M.F. ,   the WARRIOR Trial Study Group
Published: August 2020

Background:
The clinical consequences of routine follow-up radiographs for patients with ankle fracture are unclear, and their usefulness is disputed. The purpose of the present study was to determine if routine radiographs made at weeks 6 and 12 can be omitted without compromising clinical outcomes.

Methods:
This multicenter randomized controlled trial with a noninferiority design included 246 patients with an ankle fracture, 153 (62%) of whom received operative treatment. At 6 and 12 weeks of follow-up, patients in the routine-care group (n = 128) received routine radiographs whereas patients in the reduced-imaging group (n = 118) did not. The primary outcome was the Olerud-Molander Ankle Score (OMAS). Secondary outcomes were the American Academy of Orthopaedic Surgeons (AAOS) foot and ankle questionnaire, health-related quality of life (HRQoL) as measured with the EuroQol-5 Dimensions-3 Levels (EQ-5D-3L) and Short Form-36 (SF-36), complications, pain, health perception, self-perceived recovery, the number of radiographs, and the indications for radiographs to be made. The outcomes were assessed at baseline and at 6, 12, 26, and 52 weeks of follow-up. Data were analyzed with use of mixed models.

Results:
Reduced imaging was noninferior compared with routine care in terms of OMAS scores (difference [β], −0.9; 95% confidence interval [CI], −6.2 to 4.4). AAOS scores, HRQoL, pain, health perception, and self-perceived recovery did not differ between groups. Patients in the reduced-imaging group received a median of 4 radiographs, whereas those in the routine-care group received a median of 5 radiographs (p < 0.05). The rates of complications were similar (27.1% [32 of 118] in the reduced-imaging group, compared with 22.7% [29 of 128] in the routine-care group, p = 0.42). The types of complications were also similar.

Conclusions:
Implementation of a reduced-imaging protocol following an ankle fracture has no measurable negative effects on functional outcome, pain, and complication rates during the first year of follow-up. The number of follow-up radiographs can be reduced by implementing this protocol.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.