bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy Efficient Low-Cost Housing in Ho Chi Minh using EDGE Buildings
Authors: Rahmadyani Helfa , Suhendri  
Published: August 2020

Abstract
Various forecasts on the urbanization rate in the world state that more than 50% of the world’s population will live in cities by 2030. In the condition of land scarcity i.e. the land availability in the city is limited, a compact development is needed. Compact development will be closely related to Transit-Oriented Development (TOD). Transit-oriented development is not only about transit, but consisting of mixture development of housing, office, retail, and/or other amenities. In this type of development, vertical housing is unavoidable, including housing schemes for a low-income citizen, thus well-performed low-cost housing is important to be studied. Among the numerous studies, some focus on the construction materials and methods, some others on the comfort and health aspect, more on the management of the building, and not least focus on energy consumption of the housing building. This study develops an energy-efficient low-cost apartment through the calculation of various passive and active design strategies. The study uses two parameters i.e. energy saving percentage and incremental cost to determine the most optimal combination strategies. The case study in this research is in Ho Chi Minh City, Vietnam. The comparison of the design alternatives is done quantitatively using EDGE Buildings. The combination of low-cost housing design strategies can save energy by 49.86% with an incremental cost of 27,598,581 VND and the payback period in 5.21 years.
Environment Responses by Professional Role on Current Building to Achieve Sustainability: Bandung as a case study
Authors: Juliardi Robby Dwiko , Misnan Moh , Khalid A. G. 
Published: August 2020

Abstract
According to the TOD development plan, issues and topics focus on the professional role of the environment responses aspect of the current building. Thus, this provides to the existing building towards the green achievement as the consequences of green implementation. Providing a clear overview for the reader, that the environment responses is one of the measures forward to mitigate significant impacts of the building stock on the environment, society, and economy. Professional for respondents taken from Bandung, Indonesia, exploring for knowledge and awareness. However, this paper consists of a critical review of the existing body of knowledge of professionals related to the role of sustainable achievement. Both definitions and scope of TOD development and infrastructure of the current buildings around on sustainability and discussions approach to achieve how professionals recognize their role in those aspects. Besides, predominately focus of professional knowledge as the aspects which are affecting sustainable building achievement. Finally, the components as the result must be considered during the pre-construction works period, which will be followed up by professionals in Bandung depend on TOD location. The nine attentions as the findings of the result to be carried out by professionals showing their role to realize and control of physical infrastructure that surround the TOD area in Bandung for the future through developing a strategy on green or sustainability control.
Floor Design Strategies for Low Carbon Apartment towards Sustainable Transit Oriented Development
Authors: Larasati Dewi , Hanifah Yulita , Reztrie Noveryna Dwika , Nugrahanti Fathina Izmi 
Published: August 2020

Abstract
Reconsider design strategies for apartment constructions to achieve the ideal vision of TOD can be implemented through material use. It expected people living in urban areas are increasing and the construction will be increasing. A case study analysis is presented in order to show how floor design contributes to a building’s embodied impact. Results are presented in the form of an impact allocation scheme and an impact reduction scheme. Strategies of floor material usage can be implemented by the designer to reduce carbon footprint impacts. Material finishing such as ceramics and the size of modular material consistently giving significant impact, however, the designer also needs to consider the unit layout. Waste of the material affected to give rise the carbon emission. A designer should consider the factor of carbon emission impact since the early design stages on these decisions that achieve a large embodied impact reduction.
BIM Implementation to Improve Construction Work Performance
Authors: Larasati Dewi , Hanifah Yulita , Willis Furry Andini , Nugrahanti Fathina Izmi , Lubis Irma Handayani 
Published: August 2020

Abstract
In the development of Transit-oriented Areas (TOD), infrastructure development including building construction is the most crucial stage due to the large value of investment in this sector. However, some facts convey that the performance of construction projects is still very low, both in terms of cost, quality, time, and service level. This is happened partly due to the character of construction projects that have high risks and high uncertainties, involve many stakeholders, and go through various stages. Various attempts are made to improve the performance of the project, including utilizing BIM in overcoming various problems that arise due to the distinctive character of the construction project and the temporary nature of the project. The implementation of BIM in the observed case study shows that BIM as a system can contribute to improve the communication system between stakeholders, help identify risks, and help ensure all information can be conveyed properly at each transition stage of the project.
Innate immune-mediated antiviral response to SARS-CoV-2 and convalescent sera a potential prophylactic and therapeutic agent to tackle COVID-19
Authors: Abdullah  , Faisal Shah , Aman Komal , Rahman Anees ur 
Published: August 2020

ABSTRACTThe whole world is confronting the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Unfortunately, there is no vaccine to prevent novel coronavirus infection. Besides several experimental drugs, the strong immune responses and convalescent sera are the current two potential options to tackle coronavirus disease 2019 (COVID-19) infection. Innate immune-mediated antiviral responses are initiated by the recognition of viral invasion through pathogen-associated molecular patterns (PAMPs). In coronavirus, the PAMPs are recognized by Toll-like receptors 3 and 7, endosomal ribonucleic acid receptors, RNA in cytosol, and by pattern recognition receptor (RIG-1) in the alveolar cells and site of invasion. Nuclear factor-κB and interferon regulatory transcription factor (IRF3) are activated in response to the above recognition episode and translocate to nucleus. These transcription factors in the nucleus initiate the expression of interferon type 1 and pro-inflammatory cytokine storm, which leads to first line of defense at the site of viral entrance. The effectiveness of innate immune system is greatly relies on type 1 interferons and its cascade, because of their role in the inhibition of viral replication and initiation of adaptive immune responses. The successful interferon type 1 response put down the viral replication and transmission at prompt point. Passive immunization is the administering of antibodies into infected patients, which is taken from recovered individuals. The convalescent sera of the recovered COVID-19 patients are containing antiviral neutralizing antibodies and are used therapeutically for infected individuals by SARS-CoV-2 and for the purpose of prophylaxis in exposed individuals. The convalescent sera is found effective when administered early at the onset of symptoms.
FS–GBDT: identification multicancer-risk module via a feature selection algorithm by integrating Fisher score and GBDT
Authors: Zhang Jialin , Xu Da , Hao Kaijing , Zhang Yusen , Chen Wei , Liu Jiaguo , Gao Rui , Wu Chuanyan , De Marinis Yang 
Published: August 2020

Abstract
Cancer is a highly heterogeneous disease caused by dysregulation in different cell types and tissues. However, different cancers may share common mechanisms. It is critical to identify decisive genes involved in the development and progression of cancer, and joint analysis of multiple cancers may help to discover overlapping mechanisms among different cancers. In this study, we proposed a fusion feature selection framework attributed to ensemble method named Fisher score and Gradient Boosting Decision Tree (FS–GBDT) to select robust and decisive feature genes in high-dimensional gene expression datasets. Joint analysis of 11 human cancers types was conducted to explore the key feature genes subset of cancer. To verify the efficacy of FS–GBDT, we compared it with four other common feature selection algorithms by Support Vector Machine (SVM) classifier. The algorithm achieved highest indicators, outperforms other four methods. In addition, we performed gene ontology analysis and literature validation of the key gene subset, and this subset were classified into several functional modules. Functional modules can be used as markers of disease to replace single gene which is difficult to be found repeatedly in applications of gene chip, and to study the core mechanisms of cancer.
DREIMT: a drug repositioning database and prioritization tool for immunomodulation
Authors: Troulé Kevin , López-Fernández Hugo , García-Martín Santiago , Reboiro-Jato Miguel , Carretero-Puche Carlos , Martorell-Marugán Jordi , Martín-Serrano Guillermo , Carmona-Sáez Pedro , Glez-Peña Daniel , Al-Shahrour Fátima , Gómez-López Gonzalo 
Published: August 2020

Abstract

Motivation
Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases.

Results
DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4960 drug profiles and ∼2600 immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug–signature association scores, FDRs and downloadable plots and results tables.

Availabilityand implementation
http://www.dreimt.org.

Supplementary information
Supplementary data are available at Bioinformatics online.
Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model
Authors: Zhang Chun-Qing , Catron Mackenzie A , Ding Li , Hanna Caitlyn M , Gallagher Martin J , Macdonald Robert L , Zhou Chengwen 
Published: August 2020

Abstract
Epileptic activity in genetic generalized epilepsy (GGE) patients preferentially appears during sleep and its mechanism remains unknown. Here, we found that sleep-like slow-wave oscillations (0.5 Hz SWOs) potentiated excitatory and inhibitory synaptic currents in layer V cortical pyramidal neurons from wild-type (wt) mouse brain slices. In contrast, SWOs potentiated excitatory, but not inhibitory, currents in cortical neurons from a heterozygous (het) knock-in (KI) Gabrg2+Q/390X model of Dravet epilepsy syndrome. This created an imbalance between evoked excitatory and inhibitory currents to effectively prompt neuronal action potential firings. Similarly, physiologically similar up-/down-state induction (present during slow-wave sleep) in cortical neurons also potentiated excitatory synaptic currents within brain slices from wt and het KI mice. Moreover, this state-dependent potentiation of excitatory synaptic currents entailed some signaling pathways of homeostatic synaptic plasticity. Consequently, in het KI mice, in vivo SWO induction (using optogenetic methods) triggered generalized epileptic spike-wave discharges (SWDs), being accompanied by sudden immobility, facial myoclonus, and vibrissa twitching. In contrast, in wt littermates, SWO induction did not cause epileptic SWDs and motor behaviors. To our knowledge, this is the first mechanism to explain why epileptic SWDs preferentially happen during non rapid eye-movement sleep and quiet-wakefulness in human GGE patients.
Novel Eco-friendly HPLC Methods Using Refractive Index Detector for Analysis of Three Veterinary Antibiotics in Pharmaceutical Formulations and Rat Plasma
Authors: Gamal Mohammed , Elhalim Lobna Mohammed Abd 
Published: August 2020

Abstract
Antibiotic resistance increases the human mortality rate nowadays. The main purpose of the present study was to develop green reversed-phase high-performance liquid chromatography (RP-HPLC) methods with a refractive index detector for the assay of the three veterinary antibiotics (VAs), i.e., maduramicin ammonium (MA), apramycin sulfate (AS) and clarithromycin (CLA) in pharmaceutical dosage forms and spiked rat plasma. The method utilized isocratic elution using an ODP-40 C18 column, the flow rate was set at 1.0 mL/min and negative polar signals. The linearity ranges were 3.0–18.0 μg/mL for MA, 1.5–4.0 μg/mL for AS and 0.5 to 3.0 μg/mL for CLA, respectively. Liquid-liquid extraction (LLE) procedure was optimized in plasma samples. The recoveries percentages were 85.4, 81.2 and 88.8 correspondingly, in rat plasma. However, the drugs extraction by protein precipitation method yields very poor recoveries (around 50%). The new HPLC- refractive index (RI) methods are better than the previously reported HPLC-ultra violet methods in terms of greenness and simplicity of procedures. Moreover, the previously reported LC–MS methods lack the simplicity and availability of such expensive techniques in Quality control (QC) labs. The novelty of this research is the use of refractive index detector for the first time for VAs analysis.
American Archias: Cicero and The Souls of Black Folk
Authors: Withun David 
Published: August 2020

Abstract
While scholars have long noted the classical influences apparent in the style and thought of W. E. B. Du Bois, there has been little sustained discussion of the nature of these influences and their manifestations in his writings. This article seeks to correct that absence through an examination of the influence of Cicero’s Pro Archia poeta on Du Bois’s most well-known work, The Souls of Black Folk. Though Du Bois mentions many other authors in Souls, the Pro Archia is the only work of another author mentioned by name as a source for Du Bois’s thought. Extrapolating from this explicit reference to the Pro Archia as well as numerous other references to and influences by Cicero’s works throughout Du Bois’s oeuvre, I posit a two-fold influence of the Pro Archia on Souls as Du Bois draws upon the dual argument in Cicero’s work. First, Du Bois seeks to defend the civil rights of African Americans, drawing on Cicero’s argument for the legal status and citizenship rights of the poet Archias. Both Cicero and Du Bois go beyond mere legal argumentation, however, to provide a defence of the necessity of the liberal arts and a celebration of poets and their work.
Afterword: Bending the Rules
Authors: Stamatakis Chris 
Published: August 2020

Abstract
This afterword to ‘Artes Poeticae: Formations and Transformations, 1500–1650’ surveys some of the organizing themes and questions that bind the various chapters of this special issue of CRJ. Particular attention is paid to the various, arguably evolving, attitudes to rules inherited from or retrospectively sourced in classical antiquity by early modern writers and commentators. The afterword attributes much of the early modern contestation over rules to lexical minutiae in (principally) Aristotelian and Horatian poetics and considers how writers in the period 1500–1650 derive literary-critical capital from those moments when familiar categories and definitions break down.
#MondayNightIBD: Management of Chronic #Pouchitis
Authors: Donet Jean A , Rieder Florian , Charabaty Aline 
Published: August 2020

Abstract
We present a #MondayNightIBD case of chronic pouchitis and discuss key diagnostic and therapeutic challenges commonly encountered in clinical practice. We make reference not only to the limited published literature but also to the informed opinions of the #MondayNightIBD discussion participants, identifying gaps where management guidelines and research are needed. A #MondayNightIBD Algorithm for Pouchitis Management is proposed.
Polistes versicolor (Hymenoptera: Vespidae), an Introduced Wasp in the Galapagos Islands: Its Life Cycle and Ecological Impact
Authors: Parent Christine E , Peck Stewart B , Causton Charlotte E , Roque-Albelo Lázaro , Lester Philip J , Bulgarella Mariana 
Published: August 2020

Abstract
The yellow paper wasp, Polistes versicolor (Olivier) was first recorded in the Galapagos archipelago in 1988. Its life cycle and ecological impacts were studied on two islands 11 yr after it was first discovered. This invasive wasp adapted quickly and was found in most environments. Colony counts and adult wasp monitoring showed a strong preference for drier habitats. Nest activities were seasonally synchronized, nest building followed the rains in the hot season (typically January–May), when insect prey increases, and peaked as temperature and rains started to decline. Next, the number of adult wasps peaked during the cool season when there is barely any rain in the drier zones. In Galapagos, almost half of the prey loads of P. versicolor were lepidopteran larvae, but wasps also carried spiders, beetles, and flies back to the colonies. An estimated average of 329 mg of fresh insect prey was consumed per day for an average colony of 120–150 wasp larvae. The wasps preyed upon native and introduced insects, but likely also affect insectivorous vertebrates as competitors for food. Wasps may also compete with native pollinators as they regularly visited flowers to collect nectar, and have been recorded visiting at least 93 plant species in Galapagos, including 66 endemic and native plants. Colonies were attacked by a predatory moth, Taygete sphecophila (Meyrick) (Lepidoptera: Autostichidae), but colony development was not arrested. High wasp numbers also affect the activities of residents and tourists. A management program for this invasive species in the archipelago is essential.
Long-term outcomes after reoperation for mitral paravalvular leaks: a single-centre experience
Authors: Yajima Shin , Fukushima Satsuki , Yamashita Kizuku , Shimahara Yusuke , Tadokoro Naoki , Kakuta Takashi , Sakaniwa Ryoto , Kobayashi Junjiro , Fujita Tomoyuki 
Published: August 2020

Abstract

OBJECTIVES
We aimed to analyse the pathology of paravalvular leak (PVL), and determine the long-term outcomes of redo mitral valve replacement and risk factors of all-cause mortality.

METHODS
Seventy-nine patients (mean age 70 ± 9 years; 54 female, 68%) who underwent redo mitral valve replacement for mitral PVL between January 2000 and May 2019 were retrospectively reviewed. Indications for PVL intervention were haemolytic anaemia (57/79, 72%), New York Heart Association class III/IV congestive heart failure (56/79, 71%) and prosthetic valve endocarditis with PVL (2/79, 3%).

RESULTS
PVL most commonly occurred at lateral sectors (42/79, 55%). Early mortality occurred in 2 patients (3%) due to low cardiac output syndrome. Two patients (3%) had residual PVL at discharge. Sixteen patients (23%) developed late PVL (mean follow-up, 3.4 ± 2.9 years), among whom 11 (69%) developed PVL at same area as that preoperatively. Additionally, 9 patients (56%) developed PVL at lateral sectors in late follow-up. At 1, 5 and 10 years, the survival rate was 93%, 72% and 45%; rate of freedom from cardiac death was 96%, 92% and 78%; and rate of freedom from PVL recurrence was 94%, 82% and 54%, respectively. Chronic kidney disease was the only risk factor in the multivariate analysis for mortality [P = 0.013; hazard ratio 4.0 (1.4–11.0)].

CONCLUSIONS
Surgery for mitral PVL confers reasonable early and long-term outcomes. Greater attention to the anterolateral annulus may help prevent PVL.
Domestic industrialization under colonization: evidence from Korea, 1932–1940
Authors: Arimoto Yutaka , Lee Changmin 
Published: August 2020

Abstract
This paper examines whether the influx of Japanese establishments in colonial Korea during the 1930s suppressed the entry of Korean establishments. We construct new subsector–county-level panel data to exploit variations across counties within subsectors. We find that Korean entry rates were higher in counties with a higher presence of Japanese establishments. However, the spillover effects do vary across subsectors, and we find suggestive evidence of negative impacts of Japanese presence in subsectors with more large-scaled establishments. Taken together, Japanese establishments did seem to raise entry barriers in some subsectors but also functioned as a catalyst for Korean entry in other subsectors.
Mobile health applications for managing atrial fibrillation for healthcare professionals and patients: a systematic review
Authors: Lane Deirdre A , McMahon Naoimh , Gibson Josephine , Weldon Jo C , Farkowski Michal M , Lenarczyk Radoslaw , Watkins Caroline L , Dilaveris Polychronis , Caiani Enrico G , Potpara Tatjana S 
Published: August 2020

Abstract

Aims
A plethora of mobile health applications (m-health apps) to support healthcare are available for both patients and healthcare professionals (HCPs) but content and quality vary considerably and few have undergone formal assessment. The aim is to systematically review the literature on m-health apps for managing atrial fibrillation (AF) that examine the impact on knowledge of AF, patient and HCP behaviour, patients’ quality-of-life, and user engagement.

Methods and results
MEDLINE, EMBASE, CINAHL, and PsychInfo were searched from 1 January 2005 to 5 September 2019, with hand-searching of clinical trial registers and grey literature. Studies were eligible for inclusion if they reported changes in any of the following: (i) knowledge of AF; (ii) provider behaviour (e.g. guideline adherence); (iii) patient behaviour (e.g. medication adherence); (iv) patient quality-of-life; and (v) user engagement. Two reviewers independently assessed articles for eligibility. A narrative review was undertaken as included studies varied widely in their design, interventions, comparators, and outcomes. Seven studies were included; six m-health apps aimed at patients and one at HCPs. Mobile health apps ranged widely in design, features, and method of delivery. Four studies reported patient knowledge of AF; three demonstrated significant knowledge improvement post-intervention or compared to usual care. One study reported greater HCP adherence to oral anticoagulation guidelines after m-health app implementation. Two studies reported on patient medication adherence and quality-of-life; both showed improved quality-of-life post-intervention but only one observed increased adherence. Regarding user engagement, five studies reported patient perspectives on usability, three on acceptability, and one on feasibility; overall all m-health apps were rated positively.

Conclusion
Mobile health apps demonstrate improvements in patient knowledge, behaviour, and quality of life. Studies formally evaluating the impact of m-health on HCP behaviour are scarce and larger-scale studies with representative patient cohorts, appropriate comparators, and longer-term assessment of the impact of m-health apps are warranted.