bluuebunny/crossref_metadata_2025_split huggingface dataset:
As vivências artísticas como práticas de inclusão
Authors: Junior José Cavalcante Lacerda , Higuchi Maria Inês Gasparetto 
Published: November 2020

As vivências artísticas aglutinam um exercício afetivo no campo das artes. Por sua vez, observa-se nos últimos anos que os processos de inclusão cada vez mais ganham relevância em propostas de atendimento das crianças com deficiência. Imerso nessa conjuntura, como pensar processos de inclusão a partir das vivências artísticas realizadas por crianças com deficiência? De outra forma, de que maneira a arte se configura como um instrumento de inclusão? Articulado nessa perspectiva, esse artigo procura compreender de que maneira as vivências artísticas se constituem em processos inclusivos para as crianças com deficiência. O lócus de realização da pesquisa é o Liceu de Artes e Ofícios Claudio Santoro, na cidade de Manaus, Amazonas. Para este estudo foi analisado os relatórios de atividades da instituição voltados para a inclusão, entre 2015-2018, além da observação participante realizada no mesmo período. Os resultados obtidos a partir da aplicação da análise de conteúdo sinalizam que as vivências artísticas ao considerar as crianças com deficiência em suas diferenças, em suas socializações, em suas apropriações da cidade, perpassam relações de constantes reorganizações. Esse processo promove o reordenamento dos espaços físicos e adaptações curriculares, os quais sinalizam para um exercício flexível de ações psicopedagógicas que visam permitir a presença dessas crianças em suas atividades institucionais.
Representação política feminina sob a ótica das eleitoras brasileiras
Authors: Barros Antonio Teixeira de , Busanello Elisabete , Silva Anderson Henrique da , Fernandes Antônio Alves Tôrres 
Published: November 2020

Como as eleitoras brasileiras avaliam a representação política feminina? A sub-representação feminina seria um problema para elas? Com base nessas questões, o artigo analisa as percepções do eleitorado feminino obtidas por meio de survey, com 812 informantes, em 2019. Os principais resultados mostram insatisfação das mulheres com o número de representantes femininas na política, desaprovação das instituições legislativas municipais, estaduais e do Congresso Nacional quanto à atuação parlamentar voltada para as mulheres. Apenas 10% das respondentes conhecem algum partido político que defenda os interesses e direitos das mulheres.
Kognitivni upad in demenca pri Parkinsonovi bolezni
Authors: Žakelj Nina , Menih Marija , Rakuša Martin 
Published: November 2020

Parkinsonova bolezen (PB) je nevrodegenerativna bolezen možganov, ki se kaže z motoričnimi in nemotoričnimi znaki. Med motorične znake prištevamo tremor, rigidnost in bradikinezijo, med nemotoričnimi pa je najpogostejši kognitivni upad.
Rezultati longitudinalnih raziskav kažejo, da pri 80 % bolnikov kognitivni upad napreduje do demence (PBD). Vpliv PBD na življenje je velik. Če kognitivni upad prepoznamo dovolj zgodaj, lahko simptome PBD olajšamo in s tem izboljšamo kakovost posameznikovega življenja.
V preglednem članku se bomo dotaknili najpogostejših vzrokov za nastanek kognitivnega upada, vpliva dednosti in prikazali značilno klinično sliko. Za prepoznavo kognitivnega upada uporabljamo kognitivne teste, npr. Montrealsko lestvico ocenjevanja spoznavnih sposobnosti (MoCA), Baterijo testov frontalnih funkcij (FAB), Kratek poskus spoznavnih sposobnosti (KPSS) in test Testiraj svoj spomin (TSS). Na koncu članka bomo prikazali možnosti simptomatskega zdravljenja z zdravili, ki jih imamo na voljo, ter z zdravili in postopki, ki so še v fazi razvoja.
Gut microbiota in hospitalized children with acute infective gastroenteritis caused by virus or bacteria in a regional Peruvian hospital
Authors: Taco-Masias Andre Alonso , Fernandez-Aristi Augusto R. , Cornejo-Tapia Angela , Aguilar-Luis Miguel Angel , del Valle Luis J. , Silva-Caso Wilmer , Zavaleta-Gavidia Victor , Weilg Pablo , Cornejo-Pacherres Hernán , Bazán-Mayra Jorge , Puyen Zully M. , del Valle-Mendoza Juana 
Published: November 2020

Background
Acute infective gastroenteritis (AIG) is a leading cause of mortality in children worldwide. In Peru, more than 40% of cases of AIG occurring in children under 5 years old. The disruption of the gut microbiota can increase risk for several health complications especially in patients with gastric infections caused by viruses or bacteria.

Objective
The main objective of this study was to describe the prevalence of 13 representative bacteria from the gut microbiota (GM) in stools samples from children under 5 years of age with acute infective gastroenteritis.

Results
The most commonly isolated bacteria from the GM were Firmicutes (63.2% 74/117) Bacteriodetes (62.4%; 73/117), Lactobacillus (59.8%; 70/117), Prevotella (57.2%; 67/117), Proteobacterium (53.8%; 63/117), regardless of the etiological agent responsible for the AIG. Interestingly, despite the high prevalence of Firmicutes, Bacteroidetes, Lactobacillus and Prevotella across all samples, a visible reduction of these agents was observed especially among patients with a single bacterial infection or even bacteria–bacteria coinfections when compared to viral etiologies. Patients with exclusive or mixed breastfeeding registered the highest amount of gut microbiota bacteria, in contrast to infants who received formula or were not breastfed.
Differentially expressed serum proteins in children with or without asthma as determined using isobaric tags for relative and absolute quantitation proteomics
Authors: Li Ming , Wu Mingzhu , Qin Ying , Liu Huaqing , Tu Chengcheng , Shen Bing , Xu Xiaohong , Chen Hongbo 
Published: November 2020

Background
Although asthma is one of the most common chronic, noncommunicable diseases worldwide, the pathogenesis of childhood asthma is not yet clear. Genetic factors and environmental factors may lead to airway immune-inflammation responses and an imbalance of airway nerve regulation. The aim of the present study was to determine which serum proteins are differentially expressed between children with or without asthma and to ascertain the potential roles that these differentially expressed proteins (DEPs) may play in the pathogenesis of childhood asthma.

Methods
Serum samples derived from four children with asthma and four children without asthma were collected. The DEPs were identified by using isobaric tags for relative and absolute quantitation (iTRAQ) combined with liquid chromatography tandem mass spectrometry (LC-MS/MS) analyses. Using biological information technology, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Cluster of Orthologous Groups of Proteins (COG) databases and analyses, we determined the biological processes associated with these DEPs. Key protein glucose-6-phosphate dehydrogenase (G6PD) was verified by enzyme linked immunosorbent assay (ELISA).

Results
We found 46 DEPs in serum samples of children with asthma vs. children without asthma. Among these DEPs, 12 proteins were significantly (>1.5 fold change) upregulated and 34 proteins were downregulated. The results of GO analyses showed that the DEPs were mainly involved in binding, the immune system, or responding to stimuli or were part of a cellular anatomical entity. In the KEGG signaling pathway analysis, most of the downregulated DEPs were associated with cardiomyopathy, phagosomes, viral infections, and regulation of the actin cytoskeleton. The results of a COG analysis showed that the DEPs were primarily involved in signal transduction mechanisms and posttranslational modifications. These DEPs were associated with and may play important roles in the immune response, the inflammatory response, extracellular matrix degradation, and the nervous system. The downregulated of G6PD in the asthma group was confirmed using ELISA experiment.

Conclusion
After bioinformatics analyses, we found numerous DEPs that may play important roles in the pathogenesis of childhood asthma. Those proteins may be novel biomarkers of childhood asthma and may provide new clues for the early clinical diagnosis and treatment of childhood asthma.
Analysis of Added Value of Catfish Raw Leather Cracker Product (Case Study at CV. Raja Patin, Sugiharjo Village, Deli Serdang Regency, North Sumatra Province)
Authors: Bangun Jefry Yoris , Junianto . 
Published: November 2020

This study aims to analyze the added value of the catfish skin cracker product in CV. Raja Patin, Sugiharjo Village, North Sumatra Province. The method used in this research is a case study method and quantitative descriptive analysis as data analysis used. The sampling technique was carried out using a purposive sampling method. The added value of the fish skin cracker product is IDR 31,700 / kg with an added value ratio of 67.44%. Fish products that are processed into fish crackers are worth 0.47 times the price of fresh fish. This indicates that processing activities provide a sizeable contribution to economic value added and product added value.
PdCl2/CuCl2/Bi(OTf)3‐promoted Construction of Sulfonyl Dibenzooxabicyclo[3.3.1]nonanes and Arylnaphthalenes via Intramolecular Annulation of Sulfonyl o‐Allylarylchromanones
Authors: Hsueh Nai‐Chen , Chang Meng‐Yang 
Published: November 2020

AbstractPdCl2/CuCl2/Bi(OTf)3‐promoted intramolecular domino annulation of sulfonyl o‐allylarylchromanones provides tetracyclic sulfonyl dibenzooxabicyclo[3.3.1]nonanes and bicyclic arylnaphthalenes with good to excellent yields in MeOH at room (25 °C) and refluxing (65 °C) temperature, respectively. The starting sulfonyl o‐allylarylchromanones can be easily obtained from the intermolecular cyclocondensation of α‐sulfonyl o‐hydroxyacetophenones and o‐allylbenzaldehydes. The uses of various catalysts and solvent systems are investigated herein for convenient transformation. A plausible mechanism is proposed and discussed. This protocol provides one‐pot ring closure via carbon‐carbon (C−C) bond formation.magnified image
Gold Catalysis Meets Materials Science – A New Approach to π‐Extended Indolocarbazoles
Authors: Hendrich Christoph M. , Bongartz Lukas M. , Hoffmann Marvin T. , Zschieschang Ute , Borchert James W. , Sauter Désirée , Krämer Petra , Rominger Frank , Mulks Florian F. , Rudolph Matthias , Dreuw Andreas , Klauk Hagen , Hashmi A. Stephen K. 
Published: November 2020

AbstractHerein we describe a modular, convergent synthesis of substituted benzo[a]benzo[6,7]‐indolo[2,3‐h]carbazoles (BBICZs) using a bidirectional gold‐catalyzed cyclization reaction as a key step. A building block strategy enabled the easy variation of substituents at different positions of the core structure and a general analysis of substitution effects on the materials properties of the target compounds. All BBICZs were fully characterized and their optical and electronic properties were studied experimentally as well as by computational methods. Organic thin‐film transistors based on eight selected derivatives were fabricated by vacuum deposition and charge‐carrier mobilities up to 1 cm2/Vs were measured.magnified image
Self‐Assembled Solid‐State Gel Catholyte Combating Iodide Diffusion and Self‐Discharge for a Stable Flexible Aqueous Zn–I2 Battery
Authors: Sonigara Keval K. , Zhao Jingwen , Machhi Hiren K. , Cui Guanglei , Soni Saurabh S. 
Published: November 2020

AbstractAqueous rechargeable zinc–iodine batteries (ARZIBs) represent a promising form of sustainable energy storage, having highly abundant and environmentally workable elements. The low utilization of solid iodine and self‐discharge due to the diffusive properties of the soluble polyiodides in aqueous media hamper the stability and device design. The concept of building a solid‐state ARZIB with self‐discharge control by limiting iodide diffusion employing solid–gel reactions with water‐based gel‐embedded I3−/I− in block copolymer bearing highly active iodine components is demonstrated. The catholyte gel has an amphiphilic property that provides high solubility for iodine and better ionic conductivity from the cubic microcrystalline self‐assembled structures. This gel prevents long range iodide ion diffusion in multilayer self‐assemblies of the catholyte followed by the gel electrolyte layer due to self‐trapped polyiodides at the core–shell interface and inside the hydrophobic core of micelles. By contrast, positive zinc ions easily diffuse through the hydrophilic poly(ethylene oxide)‐water‐rich channels. This solid matrix results in a discharge capacity of 210 mAh g−1 (at 1 C rate) and stability with a retaining capacity of 94.3% after 500 cycles, including self‐discharge protection. The flexible module device shows excellent flexibility during deformations and the ability to power gadgets with stable performance.
Identifying the Origins of Microstructural Defects Such as Cracking within Ni‐Rich NMC811 Cathode Particles for Lithium‐Ion Batteries
Authors: Heenan Thomas M. M. , Wade Aaron , Tan Chun , Parker Julia E. , Matras Dorota , Leach Andrew S. , Robinson James B. , Llewellyn Alice , Dimitrijevic Alexander , Jervis Rhodri , Quinn Paul D. , Brett Dan J. L. , Shearing Paul R. 
Published: November 2020

AbstractThe next generation of automotive lithium‐ion batteries may employ NMC811 materials; however, defective particles are of significant interest due to their links to performance loss. Here, it is demonstrated that even before operation, on average, one‐third of NMC811 particles experience some form of defect, increasing in severity near the separator interface. It is determined that defective particles can be detected and quantified using low resolution imaging, presenting a significant improvement for material statistics. Fluorescence and diffraction data reveal that the variation of Mn content within the NMC particles may correlate to crystallographic disordering, indicating that the mobility and dissolution of Mn may be a key aspect of degradation during initial cycling. This, however, does not appear to correlate with the severity of particle cracking, which when analyzed at high spatial resolutions, reveals cracking structures similar to lower Ni content NMC, suggesting that the disconnection and separation of neighboring primary particles may be due to electrochemical expansion/contraction, exacerbated by other factors such as grain orientation that are inherent in such polycrystalline materials. These findings can guide research directions toward mitigating degradation at each respective length‐scale: electrode sheets, secondary and primary particles, and individual crystals, ultimately leading to improved automotive ranges and lifetimes.
Lead‐Free Perovskite‐Inspired Absorbers for Indoor Photovoltaics
Authors: Peng Yueheng , Huq Tahmida N. , Mei Jianjun , Portilla Luis , Jagt Robert A. , Occhipinti Luigi G. , MacManus‐Driscoll Judith L. , Hoye Robert L. Z. , Pecunia Vincenzo 
Published: November 2020

AbstractWith the exponential rise in the market value and number of devices part of the Internet of Things (IoT), the demand for indoor photovoltaics (IPV) to power autonomous devices is predicted to rapidly increase. Lead‐free perovskite‐inspired materials (PIMs) have recently attracted significant attention in photovoltaics research, due to the similarity of their electronic structure to high‐performance lead‐halide perovskites, but without the same toxicity limitations. However, the capability of PIMs for indoor light harvesting has not yet been considered. Herein, two exemplar PIMs, BiOI and Cs3Sb2ClxI9‐x are examined. It is shown that while their bandgaps are too wide for single‐junction solar cells, they are close to the optimum for indoor light harvesting. As a result, while BiOI and Cs3Sb2ClxI9‐x devices are only circa 1%‐efficient under 1‐sun illumination, their efficiencies increase to 4–5% under indoor illumination. These efficiencies are within the range of reported values for hydrogenated amorphous silicon, i.e., the industry standard for IPV. It is demonstrated that such performance levels are already sufficient for millimeter‐scale PIM devices to power thin‐film‐transistor circuits. Intensity‐dependent and optical loss analyses show that future improvements in efficiency are possible. Furthermore, calculations of the optically limited efficiency of these and other low‐toxicity PIMs reveal their considerable potential for IPV, thus encouraging future efforts for their exploration for powering IoT devices.
Witteveen–Kolk syndrome: The first patient from Turkey
Authors: Ercoskun Pelin , Yuce Kahraman Cigdem 
Published: November 2020

AbstractWitteveen–Kolk syndrome is a rare genetic disorder characterized by intellectual disability, developmental delay and dysmorphic facial features including a long face with prominent forehead, depressed nasal bridge, long‐smooth philtrum and malformed ears. Skeletal abnormalities, microcephaly and malformation of the brain are other findings. This syndrome is caused by mutations in the SIN3A gene or microdeletions encompassing this gene. The protein encoded by SIN3A gene plays a regulatory role in the control of various developmental processes, especially cortical expansion and maturation. To date, 17 patients have been reported in the medical literature. In this article, we reported a patient with Witteveen–Kolk syndrome who had a retrognathia as an unusually finding. To the best of our knowledge, this is the first patient of Witteveen–Kolk syndrome reported from Turkey.
Technical note: A report on the Forensic Anthropology Database for Assessing Methods Accuracy
Authors: Juarez Chelsey A. , Hughes Cris E. , Yim An‐Di 
Published: November 2020

AbstractWe report on the functionality, available support, and research capability of the Forensic Anthropology Database for Assessing Methods Accuracy (FADAMA; DOJ DUBX0213). FADAMA is an online repository for case data from identified forensic skeletal cases. The goal of FADAMA is to address the lack of adequate measures for assessing accuracy and reliability of forensic anthropology methods. FADAMA requires users to apply for access with their university or organization credentials. Verified users may upload and download anonymized case data via the user interface, after signing a terms of service agreement outlining ethical behavior. Case data uploads require information about the actual biological profile of the decedent and the forensic anthropology estimations. Uploading case data takes approximately 15–25 min. FADAMA users currently have 85 methods to select from when entering case data, with the capability to add new methods as they are developed. Access to the database is free, and online video tutorials are available for users covering database functionality. Currently, the database houses anonymized case data for over 350 identified cases from across the U.S. Funding has been allocated for a database technician to assist offices with large caseloads to upload cases. As it stands, the database is easy to use, and maintains thoughtful tools to assist users. The power of the database to identify trends in both method accuracy and usage is apparent, and will continue to grow as more cases are added.
AIChE PD2M Advanced Process Control workshop‐moving APC forward in the pharmaceutical industry
Authors: Huang Jun , O'Connor Thomas , Ahmed Kaschif , Chatterjee Sharmista , Garvin Chris , Ghosh Krishna , Ierapetritou Marianthi , Jeffers Malcolm , Pla David Lauri , Lee Sau L. , Lovett David , Lyngberg Olav , Mack John , McManus Eoin , Romero‐Torres Saly , Undey Cenk , Venkatasubramanian Venkat , Warman Martin 
Published: November 2020

AbstractThis whitepaper summarizes the outcome of the first Advanced Process Control (APC) workshop in the pharmaceutical industry, presented by AIChE PD2M, and held in Washington DC, Sep 30 to Oct 01, 2019. Approximately 50 attendees from regulatory agencies, industry and academia had an opportunity to share perspectives and best practices on the business, technical and regulatory aspects of APC for both small and large molecule drug manufacturing. The event consisted of keynote talks, case studies and panel discussions, filled with lively interactions that focused on: (a) Business drivers for APC in pharma; (b) Alignment on the definitions of key terminology; (c) Clarification of roles and relationships of APC with regards to popular initiatives such as Quality by Design (QbD), Process Analytical Technology (PAT), Real Time Release testing (RTRt), Continued Process Verification (CPV), continuous manufacturing and digital manufacturing; (d) APC manufacturing implementation considerations; (e) Quality system and regulatory considerations for APC implementation; (f) APC opportunities in modular manufacturing, process intensification, integrated continuous manufacturing. (g) standards, training, and collaboration.
Vinyl and Alkynyl Triazenes: Synthesis, Reactivity, and Applications
Authors: Suleymanov Abdusalom A. , Severin Kay 
Published: November 2020

AbstractAromatic compounds containing triazenyl groups (N3RR′) have a profound impact on synthetic organic and medicinal chemistry. In contrast, the chemistry of vinyl and alkynyl triazenes was a largely uncharted territory until recently. The situation has changed over the last five years, and it has become apparent that vinyl and alkynyl triazenes are highly interesting compounds with a unique reactivity. The electron‐donating properties of the triazenyl group provide alkynyl triazenes with an ynamide‐like reactivity, which can be exploited in reactions of the triple bond. Vinyl triazenes, on the other hand, can be used for electrophilic vinylation reactions. The foundation for this new triazene chemistry are synthetic pathways which allow preparing vinyl and alkynyl triazenes in few steps from readily available starting materials. In this Minireview, we summarize recent developments in this area.
A High Yield Synthesis of an Octastannacubane and a Bis(silyl) Stannylene via Reductive Elimination of a Silane
Authors: Bashkurov Roman , Kratish Yosi , Fridman Natalia , Bravo‐Zhivotovskii Dmitry , Apeloig Yitzhak 
Published: November 2020

AbstractThermolysis of tris(silyl) tin hydride 2 at 70 °C for 3 hours results in elimination of tBu2MeSiH and generation of bis(silyl) stannylene 3 which dimerizes instantaneously yielding distannene 4. Compound 3 can be trapped by NHCMe yielding stannylene‐NHCMe complex 5. Upon heating (70 °C, 24 h) 4 yields stannyl radical 8 along with pentastannatricyclo[2.1.0.02, 5]pentane 10 (ca. 30 %) and traces (ca. 5 %) of the novel octastannacubane 9. Remarkably, octastannacubane 9 is produced in 70 % yield by mild heating (50 °C) of 1,1,2,2‐tetrasilyldistannane 11, along with tBu2MeSiH. Octastannacubane 9 was characterized by X‐ray crystallography, NMR and UV/Vis spectroscopy. Based on DFT quantum‐mechanical calculations the 11 → 9 transformation occurs via reductive elimination of two tBu2MeSiH molecules from 11 yielding a distannyne, (or its bis‐stannylene isomer), followed by its tetramerization.
Entdeckung und Design promiskuitiver Acyltransferase‐Aktivität in Carboxylesterasen der Familie VIII
Authors: Müller Henrik , Godehard Simon P. , Palm Gottfried J. , Berndt Leona , Badenhorst Christoffel P. S. , Becker Ann‐Kristin , Lammers Michael , Bornscheuer Uwe T. 
Published: November 2020

AbstractPromiskuitive Acyltransferase‐Aktivität ist die Eigenschaft mancher Hydrolasen, in wässriger Lösung Acyltransfer statt Hydrolyse zu katalysieren. Niedrige Enantioselektivität bzw. Effizienz, signifikante Produkthydrolyse und das begrenzte Substratspektrum bekannter Acyltransferasen stellen erhebliche Nachteile für industrielle Anwendungen dar. Durch aktivitätsbasiertes Screening von Hydrolasen konnte die Carboxylesterase EstCE1 aus der Familie VIII als beispiellos effiziente Acyltransferase identifiziert werden. EstCE1 kann die irreversible Amidierung und Carbamoylierung von Aminen in Wasser katalysieren, wie hier am Beispiel der Synthese des Wirkstoffs Moclobemid gezeigt. Detaillierte Struktur‐Funktions‐Analysen basierend auf der hier gelösten Kristallstruktur von EstCE1 identifizierten ein Sequenz‐Motiv, das sich als bedeutsam für die promiskuitive Acyltransferase‐Aktivität herausstellte. Die Übertragung dieses Motivs führte zur Umwandlung einer “Hydrolase” in eine “Acyltransferase”.