bluuebunny/crossref_metadata_2025_split huggingface dataset:
Next steps in the identification of gene targets for type 1 diabetes
Authors: Grant Struan F. A. , Wells Andrew D. , Rich Stephen S. 
Published: August 2020

AbstractThe purpose of this review is to provide a view of the future of genomics and other omics approaches in defining the genetic contribution to all stages of risk of type 1 diabetes and the functional impact and clinical implementations of the associated variants. From the recognition nearly 50 years ago that genetics (in the form of HLA) distinguishes risk of type 1 diabetes from type 2 diabetes, advances in technology and sample acquisition through collaboration have identified over 60 loci harbouring SNPs associated with type 1 diabetes risk. Coupled with HLA region genes, these variants account for the majority of the genetic risk (~50% of the total risk); however, relatively few variants are located in coding regions of genes exerting a predicted protein change. The vast majority of genetic risk in type 1 diabetes appears to be attributed to regions of the genome involved in gene regulation, but the target effectors of those genetic variants are not readily identifiable. Although past genetic studies clearly implicated immune-relevant cell types involved in risk, the target organ (the beta cell) was left untouched. Through emergent technologies, using combinations of genetics, gene expression, epigenetics, chromosome conformation and gene editing, novel landscapes of how SNPs regulate genes have emerged. Furthermore, both the immune system and the beta cell and their biological pathways have been implicated in a context-specific manner. The use of variants from immune and beta cell studies distinguish type 1 diabetes from type 2 diabetes and, when they are combined in a genetic risk score, open new avenues for prediction and treatment.
Cohort at risk: long-term consequences of conflict for child school achievement
Authors: Jürges Hendrik , Stella Luca , Hallaq Sameh , Schwarz Alexandra 
Published: August 2020

AbstractWe investigate the long-term effects of households’ exposure to violent conflict on children’s educational attainment in primary school, studying cognitive and non-cognitive skills as possible causal channels. Our identification strategy exploits the locality-level variation in the intensity of the Israeli-Palestinian conflict in the West Bank during the Second Intifada (2000–2005). We show that an increase in family experience of conflict has large negative long-term effects on the educational attainment of children as measured by grade point averages. We find that non-cognitive rather than cognitive skills are the channels through which exposure affects children’s educational achievement.
Targeted LC-ESI-MS2 characterization of human milk oligosaccharide diversity at 6 to 16 weeks post-partum reveals clear staging effects and distinctive milk groups
Authors: Mank Marko , Hauner Hans , Heck Albert J. R. , Stahl Bernd 
Published: August 2020

AbstractMany molecular components in human milk (HM), such as human milk oligosaccharides (HMOs), assist in the healthy development of infants. It has been hypothesized that the functional benefits of HM may be highly dependent on the abundance and individual fine structures of contained HMOs and that distinctive HM groups can be defined by their HMO profiles. However, the structural diversity and abundances of individual HMOs may also vary between milk donors and at different stages of lactations. Improvements in efficiency and selectivity of quantitative HMO analysis are essential to further expand our understanding about the impact of HMO variations on healthy early life development. Hence, we applied here a targeted, highly selective, and semi-quantitative LC-ESI-MS2approach by analyzing 2 × 30 mature human milk samples collected at 6 and 16 weeks post-partum. The analytical approach covered the most abundant HMOs up to hexasaccharides and, for the first time, also assigned blood group A and B tetrasaccharides. Principal component analysis (PCA) was employed and allowed for automatic grouping and assignment of human milk samples to four human milk groups which are related to the maternal Secretor (Se) and Lewis (Le) genotypes. We found that HMO diversity varied significantly between these four HM groups. Variations were driven by HMOs being either dependent or independent of maternal genetic Se and Le status. We found preliminary evidence for an additional HM subgroup within the Se- and Le-positive HM group I. Furthermore, the abundances of 6 distinct HMO structures (including 6′-SL and 3-FL) changed significantly with progression of lactation.
Role of Primary Tumor Resection for Metastatic Small Bowel Neuroendocrine Tumors
Authors: Hallet Julie , Law Calvin ,   the Commonwealth Neuroendocrine Tumours Research Collaborative (CommNETs) Surgical Section, Hallet Julie , Law Calvin , Pasieka Janice , Koea Jonathan , Meyer‐Rochow Win 
Published: August 2020

AbstractWhile small bowel resection is well established as standard of care for curative‐intent management of localized and loco‐regional small bowel neuroendocrine tumors (SB‐NETs), resection of the primary tumor in the setting of metastatic disease is debated. This review addresses the role of primary tumor resection for stage IV well‐differentiated grade 1 and 2 SB‐NETs. While survival benefits have been reported for primary tumor resection in the setting of metastatic disease, these studies are limited by selection bias and thus controversial. The main clinical benefits of primary tumor resection for stage IV disease involve the prevention of potentially debilitating complications associated with mesenteric fibrosis, including intestinal obstruction, mesenteric ischemia and angina, venous congestion, malabsorption, and malnutrition. Patients with metastases undergoing initial resection of the primary SB‐NETs appear to have fewer episodes of care and re‐intervention for loco‐regional complications than those who do not undergo resection. As recommended by the NANETS and ENETS guidelines, resection of the primary tumor for stage IV SB‐NETs should be strongly considered to avoid future loco‐regional complications and potentially to improve survival. All patients with stage IV SB‐NETs should be assessed by a surgeon experienced in the management of NETs to consider surgical therapies, including resection of the primary tumor despite metastatic disease.
Rheology of melts from the colli albani volcanic district (Italy): a case study
Authors: Kleest Christin , Webb Sharon L. , Fanara Sara 
Published: August 2020

AbstractIn this study the first viscosity measurements in the glass transition range of melts from highly explosive large-volume eruptions from the Colli Albani Volcanic District (CAVD) are presented. The magmas are ultrapotassic, rich in iron and CaO and characterised by a low silica content (< 45 wt%). Melt compositions range from tephri-phonolitic to foiditic. The Colli Albani eruptions appear anomalous since they produced a large volume of erupted material in spite of their silica undersaturated compositions. The viscosity of the Colli Albani melt changes as the melt composition evolves from the original melt to a country-rock contaminated melt to a crystal-bearing melt with a permanent decrease in liquid viscosity. Conventional estimations of viscosities assume these magmas to have a low viscosity. The presented data show that the melt viscosities are higher than expected. Taking into account further chemical or rheological features of a melt, the investigated CAVD melts are not that striking as assumed in comparison with other large-volume eruptions. Consequently, considering the alkaline-earth to alkaline ratio together with the SiO2 content could provide an alternative when comparing large volume eruptions.
Microphysics of Inelastic Deformation in Reservoir Sandstones from the Seismogenic Center of the Groningen Gas Field
Authors: Pijnenburg Ronald P. J. , Spiers Christopher J. 
Published: August 2020

AbstractPhysics-based assessment of the effects of hydrocarbon production from sandstone reservoirs on induced subsidence and seismicity hinges on understanding the processes governing compaction of the reservoir. Compaction strains are typically small (ε < 1%) and may be elastic (recoverable), or partly inelastic (permanent), as implied by recent experiments. To describe the inelastic contribution in the seismogenic Groningen gas field, a Cam–clay-type plasticity model was recently developed, based on the triaxial test data obtained for sandstones from the Groningen reservoir (strain rate ~ 10−5 s−1). To underpin the applicability of this model at production-driven strain rates (10−12 s−1), we develop a simplified microphysical model, based on the deformation mechanisms observed in triaxial experiments at in situ conditions and compaction strains (ε < 1%). These mechanisms include consolidation of and slip on µm-thick clay films within sandstone grain contacts, plus intragranular cracking. The mechanical behavior implied by this model agrees favourably with the experimental data and Cam–clay description of the sandstone behavior. At reservoir-relevant strains, the observed behavior is largely accounted for by consolidation of and slip on the intergranular clay films. A simple analysis shows that such clay film deformation is virtually time insensitive at current stresses in the Groningen reservoir, so that reservoir compaction by these mechanisms is also expected to be time insensitive. The Cam–clay model is accordingly anticipated to describe the main trends in compaction behavior at the decade time scales relevant to the field, although compaction strains and lateral stresses may be slightly underestimated due to other, smaller creep effects seen in experiments.
Evaluating the GPCC Full Data Daily Analysis Version 2018 through ETCCDI indices and comparison with station observations over mainland of China
Authors: Yu Yu , Schneider Udo , Yang Su , Becker Andreas , Ren Zhihua 
Published: August 2020

AbstractThe new 1° × 1° resolution global Full Data Daily Analysis Version 2018 published by the Global Precipitation Climatology Centre (GPCC) of Deutscher Wetterdienst was compared with an analysis of the measurements from the national dataset over the mainland of China with regard to four of the 27 ETCCDI indices (http://etccdi.pacificclimate.org/list_27_indices.shtml) commonly used to determine extreme precipitation (Rx5day, R10mm, CDD and SDII). After extreme value check, integrity check, and homogeneity check, the observations from 2327 surface stations covering the years from 1982 to 2016 fulfilled the criteria for the evaluation. The in situ daily precipitation data were interpolated onto a 1° × 1° grid over the mainland of China by employing Shepard’s angular and distance weighting algorithm. The four aforementioned indices were then calculated on the national station–based analysis being referred to as STA. Moreover, the aforementioned gridded GPCC Full Data Daily product was directly utilized to calculate the same indices (FDDA). The China national means of Rx5day, R10mm, CDD and SDII calculated from FDDA and STA had similar variations and trends with high correlation coefficients, and the mean biases between FDDA and STA were 2.5 mm, 1.2 days, 0.0 day and 0.3 mm respectively. The trends of Rx5day, R10mm and SDII are increasing, whereas the trend of CDD is negative. The distributions of the grid mean and the grid trends of indices over China from FDDA and STA show similar patterns too, indicating that the FDDA shows a surprisingly high fidelity in reproducing almost the same patterns in the four ETCCDI indices chosen compared with the STA-based analysis.
Stieleria varia sp. nov., isolated from wood particles in the Baltic Sea, constitutes a novel species in the family Pirellulaceae within the phylum Planctomycetes
Authors: Surup Frank , Wiegand Sandra , Boedeker Christian , Heuer Anja , Peeters Stijn H. , Jogler Mareike , Jetten Mike S. M. , Rohde Manfred , Jogler Christian , Kallscheuer Nicolai 
Published: August 2020

AbstractSpecies belonging to the bacterial phylumPlanctomycetesare ubiquitous members of the microbial communities in aquatic environments and are frequently isolated from various biotic and abiotic surfaces in marine and limnic water bodies. Planctomycetes have large genomes of up to 12.4 Mb, follow complex lifestyles and display an uncommon cell biology; features which motivate the investigation of members of this phylum in greater detail. As a contribution to the current collection of axenic cultures of Planctomycetes, we here describe strain Pla52Tisolated from wood particles in the Baltic Sea. Phylogenetic analysis places the strain in the familyPirellulaceaeand suggests two species of the recently described genusStieleriaas current closest neighbours. Strain Pla52nTshows typical features of members of the classPlanctomycetia, including division by polar budding and the presence of crateriform structures. Colonies of strain Pla52nThave a light orange colour, which is an unusual pigmentation compared to the majority of members in the phylum, which show either a pink to red pigmentation or entirely lack pigmentation. Optimal growth of strain Pla52nTat 33 °C and pH 7.5 indicates a mesophilic (i.e. with optimal growth between 20 and 45 °C) and neutrophilic growth profile. The strain is an aerobic heterotroph with motile daughter cells. Its genome has a size of 9.6 Mb and a G + C content of 56.0%. Polyphasic analyses justify delineation of the strain from described species within the genusStieleria. Therefore, we conclude that strain Pla52nT= LMG 29463T= VKM B-3447T should be classified as the type strain of a novel species, for which we propose the nameStieleria variasp. nov.
Gene–Environment Interplay Between Physical Exercise and Fitness and Depression Symptomatology
Authors: Johnson Wendy , Mortensen Erik Lykke , Kyvik Kirsten Ohm 
Published: August 2020

AbstractStudies often report beneficial effects of physical exercise on depression symptomatology, both in clinical and community samples. In clinical samples, effects are observed using physical exercise as primary treatment and supplement to antidepressant medications and/or psychotherapies. Magnitudes vary with sample characteristics, exercise measure, and study rigor. Both propensity to exercise and vulnerability to depression show genetic influences, suggesting gene–environment interplay. We investigated this in a Danish Twin Registry-based community sample who completed a cycle fitness test and detailed assessments of depression symptomatology and regular exercise engagement that enabled estimates of typical total, intentional exercise-specific, and other metabolic equivalent (MET) expenditures. All exercise-related measures correlated negatively with depression symptomatology (− .07 to − .19). Genetic variance was lower at higher levels of cycle fitness, with genetic and shared environmental correlations of −  .50 and 1.0, respectively. Nonshared environmental variance in depression was lower at higher levels of total MET, with no indications of genetic or environmental covariance. Being physically active and/or fit tended to prevent depression, apparently because fewer participants with higher levels of activity and fitness reported high depression symptomatology. This was driven by nonshared environmental influences on activity but genetic influences on physical fitness. Genetic correlation suggested people less genetically inclined toward physical fitness may also be genetically vulnerable to depression, possibly because inertia impedes activity but also possibly due to social pressures to be fit. Exercise programs for general well-being should emphasize participation, not performance level or fitness. We discuss possible interrelations between fitness aptitude and metabolism.
Patients’ perceptions of medicines information received at hospital discharge in Norway: a qualitative interview study
Authors: Svensberg K. , Trapnes E. , Nguyen D. , Hasan R. A. , Sund J. K. , Mathiesen L. 
Published: August 2020

AbstractBackgroundInsufficient transfer of medicines information is a common challenge at discharge from hospital. Following discharge, home dwelling patients are expected to manage their medicines themselves and adequate counselling is an important prerequisite for patient empowerment and self-efficacy for medicines management.ObjectiveThe aim was to identify patients’ needs for medicines information after discharge from hospital, including the patients’ perception and appraisal of the information they received at discharge.SettingThe study enrolled patients discharged from three medical wards at a secondary care hospital in Oslo, Norway.MethodPatients were included at the hospital, at or close to the day of discharge and qualitative, semi-structured interviews were performed during the first 2 weeks after discharge. Eligible patients were receiving medicines treatment on admission and after discharge, were handling the medicines themselves, and discharged to their own home. Data were collected in 2017. Interviews were analysed with thematic analysis inspired by Systematic Text Condensation.Main outcome measurePatients’ perceptions of medicines information.ResultsIn total, 12 patients were interviewed. They were discharged in equal numbers from the three wards, representing both sexes and a broad age range. Patients perceive medicines information as a continuum and not limited to specific encounters, like the discharge conversation. They gain information in several ways; by receiving information from health care professionals, through observations, and by seeking it themselves. Some thought they could have been better informed about adverse reactions and how to manage life while being a medicines user. Others felt they did not want or need more information. Patients employ various strategies for coping with their use of medicines, influencing their self-efficacy towards medicine management.ConclusionMedicines information should focus on empowering the patients throughout the hospital stay and not solely at discharge, taking into account the individual patient’s needs for information, preferences and prior knowledge.
Prakāśa. A few reflections on the Advaitic understanding of consciousness as presence and its relevance for philosophy of mind
Authors: Fasching Wolfgang 
Published: August 2020

AbstractFor Advaita Vedānta, consciousness is to be distinguished from all contents of consciousness that might be introspectively detectable: It is precisely consciousness of whatever contents it is conscious of and not itself one of these contents. Its only nature is, Advaita holds,prakāśa(manifestation); in itself it is devoid of any content or structure and can never become an object. This paper elaborates on this kind of understanding of consciousness in order to next explain why it might be fruitful for developing a clear understanding of the nature of the so-called problem of consciousness. Today’s philosophy of mind tends to conceive of consciousness in terms of qualia, thereby taking it as a special kind of (introspectively accessible) object. This renders the antimaterialist claim of the distinctness of consciousness from all physical (publicly accessible) features vulnerable to the materialist reply that the difference in question might be a merely epistemological matter, i.e., a matter of different modes of givenness without difference in what is thus given. This move, however – this paper argues –, is impossible without resulting in circularity or infinite regress with regard to consciousness in the sense of givenness (manifestation) itself.
A pluralist account of the basis of moral status
Authors: Floris Giacomo 
Published: August 2020

AbstractStandard liberal theories of justice rest on the assumption that only those beings that hold the capacity for moral personality (CMP) have moral status and therefore are right-holders. As many pointed out, this has the disturbing implication of excluding a wide range of entities from the scope of justice. Call this theunder-inclusiveness objection. This paper provides a response to the under-inclusiveness objection and illustrates its implications for liberal theories of justice. In particular, the paper defends two claims: first, it argues that both the CMP and the potential capacity for moral personality (PCMP) are bases of moral status. This pluralist account of the basis of moral status can broaden the scope of justice and provide a solid philosophical justification for the common-sense intuition that almost all human beings have a moral status that isdifferentandsuperiorto that of nonhuman animals. Second,contrawhat is commonly suggested, it contends that potential and actual moral persons have different and unequal rights, other things being equal.
On the optimum catalyst for structure sensitive heterogeneous catalytic reactions
Authors: Murzin Dmitry Yu. 
Published: August 2020

AbstractReaction rates in a two-step catalytic sequence, when plotted vs adsorption energy of the key or the most abundant surface intermediate, result in volcano shaped curves. In the current work, the optimal catalyst is discussed for structure sensitive reactions, which display dependence of activity on the cluster size of the active catalytic phase. An expression is derived relating the Gibbs energy for formation of the intermediate with the Gibbs energy changes in the overall reaction, difference in adsorption thermodynamics on edges and terraces and the cluster size. The kinetic expressions display dependence of activity vs the Gibbs energy of the adsorbed intermediate formation. Numerical analysis demonstrates that when the overall equilibrium constant K is high and the reaction is thermodynamically very favorable, the maxima in the rates vs the adsorption constant for the optimal catalyst are much broader being less dependent on the cluster size. When structure sensitivity is pronounced, there are smaller differences in the rates for the optimum and less optimal catalysts in comparison with reactions showing weak structure sensitivity.
Analyzing the returns to entrepreneurship by a modified Lazear model
Authors: Hårsman Björn , Mattsson Lars-Göran 
Published: August 2020

AbstractA modified version of Lazear’s model (in American Economic Review, 94, 208-211, 2004, Journal of Labor Economics, 23, 649–680, 2005) for occupational choice is formulated. It includes a utility adjustment factor that captures the combined effect of nonpecuniary benefits and uncertainty associated with entrepreneurship. We show that the counterfactual income returns to entrepreneurship are lower than the market value of entrepreneurial talent and higher than the inverse of the utility adjustment factor. Moreover, if the skill profiles in the population are Fréchet-distributed, the ratio between the expected incomes of entrepreneurs and observationally similar wage employees is lower than the inverse of the utility adjustment factor. Thus, entrepreneurs will on average earn less than wage employees if the utility adjustment factor is greater than or equal to one. It is also shown that the self-selection bias related to this income ratio or returns measure increases with the observed percentage of entrepreneurs. Swedish employment data are used to calibrate the modified Lazear model. The empirical results indicate that uncertainty considerations might be more important for the occupational choices than nonpecuniary benefits.