bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stroke prevention in elderly patients with non‐valvular atrial fibrillation in the BALKAN‐AF survey
Authors: Potpara Tatjana S. , Simovic Stefan , Pavlovic Nikola , Nedeljkovic Milan , Paparisto Vilma , Music Ljilja , Goshev Evgenii , Loncar Daniela , Popescu Raluca , Manola Sime , Kusljugic Zumreta , Trendafilova Elina , Dan Gheorghe‐Andrei , Lip Gregory Y. H. 
Published: January 2020

AbstractBackgroundAtrial fibrillation (AF) is common amongst the elderly, but this group tends to be suboptimally treated. Limited data are available on the stroke prevention strategies in the elderly, especially in the Balkan region.AimWe investigated the use of oral anticoagulant therapy (OAC) amongst elderly AF patients in clinical practice in the Balkan region.MethodA 12‐week prospective snapshot survey (2014‐2015) of consecutive non‐valvular AF patients was conducted in Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Montenegro, Romania and Serbia. Data were collected via an electronic case report form.ResultsOf 2671 patients, 418 (15.6%) were ≥80 years old. Overall, OAC was used in 1965 patients (73.6%). Compared with younger patients, the elderly (age ≥ 80) had a higher mean CHA2DS2‐VASc score (3.22 ± 1.71 vs 4.89 ± 1.35, P < .001) and more often a HAS‐BLED score of ≥3 (n = 198 [47.0%] vs n = 625 [27.3%], P < .001), but were less likely to receive OAC (n = 269 [64.4%] vs n = 1696 [75.3%], odds ratio [OR] 0.91; 95%CI 0.86‐0.97, P = .003). There was no significant association between OAC use and mean CHA2DS2‐VASc (OR 0.86; 95%CI 0.75‐1.00, P = .053) or HAS‐BLED score (OR 1.21; 95%CI 0.81‐1.81, P = .349) in the elderly.ConclusionIn the BALKAN‐AF Survey, elderly AF patients were less likely to receive the guideline‐adherent treatment despite their less favourable risk profile. Since OAC nonuse among the elderly was not associated with increased HAS‐BLED score, factors other than patients’ risk profile could influence the implementation of guideline‐adherent treatment for thromboprophylaxis in the elderly AF patients.
Differential induction of volatiles in rice plants by two stink bug species influence behaviour of conspecifics and their natural enemy Telenomus podisi
Authors: Ulhoa Lucas Adjuto , Barrigossi José Alexandre Freitas , Borges Miguel , Laumann Raúl Alberto , Blassioli‐Moraes Maria Carolina 
Published: January 2020

AbstractTritrophic interactions mediated by semiochemicals have been intensively studied from the viewpoint of ecological relationships with Nearctic tritrophic organisms. However, there are few studies involving interactions with different herbivores on the same host plant in Neotropical systems. The objective of the current study was to investigate the effects of herbivory by two species of stink bugs (Heteroptera: Pentatomidae) with the same feeding habit – Tibraca limbativentris Stål and Glyphepomis spinosa Campos & Grazia – on indirect and direct defence strategies of rice plants. The responses of each stink bug species (virgin and mated females) and of their main natural enemy, the egg parasitoid Telenomus podisi Ashmead (Hymenoptera: Platygastridae; mated females), to volatiles from undamaged and herbivore‐damaged rice plants were evaluated using a Y‐tube olfactometer. The results showed that rice plants responded differently to T. limbativentris or G. spinosa herbivory, enhancing the production of a different blend of volatile compounds, which reduced the attraction for conspecific stink bugs and elicited the foraging behaviour of T. podisi.
Effects of recreational fishing on zooplankton communities of drainage system reservoirs at an open‐pit mine
Authors: Goździejewska Anna Maria , Skrzypczak Andrzej Robert , Koszałka Jacek , Bowszys Magdalena 
Published: January 2020

AbstractThe use of artificial water bodies for angling is a popular practice, especially in industrial and urbanised areas where natural water bodies are lost. In this study, the zooplankton structure dynamics and water quality at three strip mine drainage system reservoirs were assessed with different types of recreational fishery exploitation: K1—intensive angling using the catch‐and‐release model, K2—lowest angling pressure and higher share of predatory fishes and K3—moderate fishing, that is limiting groundbait quantities and eliminating non‐predatory fishes by anglers. The null hypothesis tested was that recreational fishing does not affect the biotic and abiotic conditions of reservoirs. The significance of each environmental variable was tested using redundancy analysis (RDA). The highest nutrients and chlorophyll a concentration, turbidity level and organic matter content occurred in K1. Zooplankton diversity was the lowest under these conditions; protozoa and larval stages of copepods dominated. In reservoirs where sustainable fishing was implemented (K2, K3), trophic parameters of water were lower, on average, by 25%, turbidity by 30%, and productivity by 35–70%. Zooplankton diversity was significantly higher; rotifers and small cladocerans dominated. The choice of recreational fishing model determines the functionality and biological potential of the reservoir.
Policy preferences and ministerial structures: Immigrant integration governance in Western Europe, 1997–2017
Authors: Hernes Vilde 
Published: January 2020

AbstractThis article tests an often‐stated assumption in the “machinery of government” literature: that government parties’ issue and policy preferences affect the ministerial structure. Using a new Dataset on Immigrant Integration Governance (DIIG) that documents the ministerial structure of immigrant integration in 16 Western European countries during 1997–2017, the analysis finds that divergence and change characterize the ministerial structure. The analysis finds that right‐oriented governments are more inclined to couple integration with immigration and justice than are left‐oriented governments, indicating different policy preferences. However, it does not find that governments with radical parties are more inclined to signal “integration” in ministerial titles. The study's comparative approach challenges the generalizability of existing knowledge on drivers of ministerial changes. Additionally, it fills a gap in current immigrant integration literature: the study of the horizontal governance structure.
UNIQUE MARKOV EQUILIBRIUM UNDER LIMITED COMMITMENT
Authors: Bloise Gaetano 
Published: January 2020

AbstractI develop a recursive method for the characterization of competitive equilibrium under limited commitment with not‐too‐tight solvency constraints. The reputational mechanism is fragile, as it sustains constrained efficiency as well as a large set of constrained inefficient equilibria. However, I establish that the only strongly ergodic Markov equilibrium with trade is constrained efficient. The method relies on a planning program along with the theory of monotone concave operators. It is suitable for other applications to macroeconomics and dynamic contracts.
INTERNATIONAL BUSINESS CYCLES IN EMERGING MARKETS
Authors: Rothert Jacek 
Published: January 2020

AbstractI document cyclical behavior of real exchange rates (RERs) in emerging and developed economies: stronger RER procyclicality coincides with larger relative volatility of consumption and more countercyclical trade balance. I then reevaluate the sources of fluctuations in emerging economies using an international business cycle model estimated to match the behavior of the RERs. Interest rate shocks, without any frictions, account for most of output fluctuations. This result is driven by imperfect substitution between domestic and foreign goods, which dampens the impact of trend shocks and accentuates the impact of interest rate shocks on output and consumption.
Effects of CaCO3 additive on properties and microstructure of corundum‐ And mullite‐based ceramic proppants
Authors: Qin Mei , Tian Yuming , Hao Huilan , Li Guomin , Zhou Yi , Bai Pinbo 
Published: January 2020

AbstractCorundum‐mullite ceramic proppants have been successfully synthesized using raw materials of natural bauxite and solid waste coal gangue, CaCO3, as additive. The influences of calcium carbonate additive on phase composition, microstructure, and mechanical performances were systematically investigated. The results indicate that the addition of CaCO3 promotes the formation of liquid phase at lower temperature during sintering process, which is beneficial to the densification of the samples and the reduction of sintering temperature. Moreover, the mullite grains become finer and finer with the content of CaCO3 additive increasing, which improves the toughness and strength of the samples via a grain refinement strengthening mechanism. The ceramic proppants exhibit optimal performances with additive of 5 wt.% at 1350°C, and the breakage ratio under 52 MPa closed pressure is the lowest. Additionally, the sintering temperature is dropped by 150°C compared with the samples without adding calcium carbonate.
Incongruous and Creative Grace: Reading Paul and the Gift with Martin Luther
Authors: Linebaugh Jonathan A. 
Published: January 2020

AbstractPaul and the Gift by John Barclay advances an interpretation of Paul’s theology of grace that resonates with Martin Luther’s reading: God’s gift is God’s Son, Jesus Christ, given for and to the unworthy. To imagine Luther reading Paul and the Gift is thus to conjure images of deep and fundamental consensus. But questions remain. Is the law a cultural canon of worth that God’s gift of Christ ignores, or is it, as God’s law, a fixed judgement that God’s grace contravenes? Does God give only ‘without regard to worth’ and thus with a kind of divine indifference to cultural indices of value, or does the gift of Christ contradict the conditions of its receipts and thus come in a way that is actually incongruous? With these questions, Luther might push back against Barclay. With others he would ask Barclay to go further. Is not God’s incongruous grace also and characteristically creative? How is the gift of Christ that God gave present to and for recipients as the gift God now gives? In all these ways, Luther’s theology of the word poses questions to or invites expansions of Barclay’s theology of grace.
Thomas Aquinas and the Potential Catholic Integration of a Dynamic Occasionalist Understanding of Grace
Authors: Murray Paul D. 
Published: January 2020

AbstractStarting out from John Barclay's Lutheran‐inclined, actualist reading of the in‐breaking quality of grace and the Spirit in Paul, this article asks how a Catholic theology of grace – typically more focused on identifying the relatively stable structures and effects of grace – might with integrity learn from the Barclayan‐Lutheran‐Pauline difference. By pursuing a close, four‐step reading of Thomas Aquinas' theology of grace, as that appears in the Summa Theologiæ and his lectures on the Pauline epistles, the article demonstrates that just such a Catholic appropriation of a more dynamic graced actualism is indeed possible; one which leads, with dynamic integrity, to a deepened understanding, articulation and practice of core Catholic instincts rather than to their reduction or distortion.
Configurations of Grace and Merit in Paul and His Interpreters
Authors: Eubank Nathan 
Published: January 2020

AbstractOne of the main findings of John Barclay’s Paul and the Gift is that divine grace was everywhere in ancient Judaism, but not everywhere the same. Though Barclay does not emphasize this point, something similar could be said about the worthiness or merit of the recipients of grace. Human worthiness is everywhere in Judaism and Christianity, but not everywhere the same. This article situates Barclay’s account of human worthiness relative to other possible configurations. According to Barclay’s Paul, the Christ‐gift is given without regard for the worth of the recipients, but this same gift remakes those to whom it is given, enabling them to become worthy of God. This account of human response places Barclay in surprisingly close proximity with non‐Protestant Augustinian streams of interpretation.
Ex Nihilo or Tabula Rasa? God's Grace between Freedom and Fidelity
Authors: Bertschmann D.H. 
Published: January 2020

AbstractJohn Barclay’s magnum opus on grace genuinely moves the discussion forward by describing grace as unconditioned but not unconditional. This essay explores the notion of unconditioned grace as the gift given regardless of worth, disregarding any social and symbolic capital in the process. Taking Romans 9–11 as its case study, this essay argues that the deepest root of Paul’s confidence is God’s fidelity to the people God loved and chose, not God’s repeated movements of creative incongruous grace. Paul knows that in Israel’s case its symbolic capital is also spiritual in pointing towards Israel’s history with God. Far from disregarding this capital and its ethnic component, Paul professes God’s abiding faithfulness to the biological descendants of the patriarchs (Rom. 11:28). In his wrestling to hold God’s astonishing freedom and enduring fidelity together Paul sketches out his gospel of radical sin and grace, where both Jews and Gentiles are equally failing (Rom. 11:32) but met and restored precisely at the point of death and destruction.
Incongruous Grace as Pattern of Experience
Authors: Zahl Simeon 
Published: January 2020

AbstractThis article examines the relationship between the theological concept of grace and the effects of grace on human beings in bodies and in time, in critical engagement with John Barclay’s account of Paul’s theology of grace in Paul and the Gift. It begins by showing how one of the book’s most significant contributions is its ‘thick’ description of the effects of incongruous grace in the world in terms of its socially transformative power in the formation of communities. It then argues that Barclay’s account is substantially less successful at giving a compelling account of the more rapid and immediate changes that Paul also associates with encounter with divine grace in the lives of Christians. The article concludes by showing how Barclay’s picture can be expanded and improved by examining how the ‘incongruity’ of grace functions to pattern experience in relatively sudden, emotionally immediate ways rather than just through the long‐term formation of a Christian habitus.
Plant type dominates fine‐root C:N:P stoichiometry across China: A meta‐analysis
Authors: Wang Zhiqiang , Lv Shiqi , Song Hui , Wang Mingcheng , Zhao Qi , Huang Heng , Niklas Karl J. 
Published: January 2020

AbstractAimFine roots play an important role in biogeochemical cycling in terrestrial ecosystems. However, our understanding of large scale biogeographical patterns and drivers of fine‐root C:N:P stoichiometry is extremely limited.LocationChina.MethodsWe compiled data for fine‐root carbon (C), nitrogen (N) and phosphorus (P) concentrations at 165 sites across China to explore large‐scale biogeographical patterns and drivers of fine‐root C:N:P stoichiometry.ResultsThe geometric means of fine‐root C, N, and P concentrations were 448.81, 10.73, and 0.9 mg/g, respectively, whereas C:N, C:P, and N:P ratios were 41.84, 508.32, and 11.73, respectively. The fine‐root elemental concentrations and their ratios varied widely among plant groups and biomes, and showed clear latitudinal and longitudinal trends, as a consequence of differences in climate, soil, and plant type. However, plant type was the largest contributor to the total variance in fine‐root C, N, and P and their ratios compared to climate factors or soil features.Main conclusionsThe data reveal the existence of broad biogeographical patterns of fine‐root C:N:P stoichiometry in China. These results advance our knowledge about the biogeochemical cycling of fine roots.
2‐mm surgical margins are adequate for most basal cell carcinomas in Japanese: a retrospective multicentre study on 1000 basal cell carcinomas
Authors: Nakamura Y. , Matsushita S. , Tanaka R. , Saito S. , Araki R. , Teramoto Y. , Aoki M. , Yamamura K. , Nakamura Y. , Fujisawa Y. , Brinker T.J. , Yamamoto A. 
Published: January 2020

AbstractBackgroundSurgery is the gold standard for basal cell carcinomas (BCC). Current recommended surgical margins for BCCs are determined from studies in Caucasian populations. However, the appropriate surgical margins for BCCs in non‐white races are unclear.ObjectivesTo investigate the accuracy of preoperative determination of clinical tumour borders and appropriate surgical margins in Japanese patients with BCC.MethodsThe maximum calculated differences in distance between the preoperatively determined surgical margins and the actual histologic tumour side margins were considered as ‘accuracy gaps’ of clinical tumour borders. Estimated side margin positivity rates (ESMPRs) with narrower (2 and 3 mm) surgical margins were calculated on the basis of the accuracy gaps.ResultsOverall, 1000 surgically excised BCCs from 980 Japanese patients were included. The most frequent histologic subtype was nodular BCC (67%). The median accuracy gap was 0.3 mm [interquartile range (IQR): −0.5 to +1 mm]. The ESMPRs with 2‐ and 3‐mm surgical margins were 3.8% and 1.4%, respectively. Only the ESMPRs between the well‐defined (n = 921) and poorly defined clinical tumour border groups (n = 79) showed statistical difference [2‐mm margin: 3.1% vs. 11.7%, OR: 3.89, 95% confidential interval (CI): 1.41–10.71, P <0.01; 3‐mm margin: 0.97% vs. 6.3%, OR: 6.58, 95% CI: 1.67–25.99, P <0.01]. No significant differences in ESMPRs were noted in other subgroups including risk classifications.ConclusionsThe determined clinical tumour border accuracy gaps in this Japanese cohort were negligible. Dermatologic surgeons may use narrower surgical margins with acceptable margin positivity rates. The clarity of clinical tumour borders could be an appropriate guide for selection of different surgical margins in the Japanese cohort.
Real‐world data from a single Greek centre on the use of secukinumab in plaque psoriasis: effectiveness, safety, drug survival, and identification of patients that sustain optimal response
Authors: Rompoti N. , Sidiropoulou P. , Panagakis P. , Stratigos A. , Papoutsaki M. , Stefanaki E. , Vavouli C. , Politou M. , Befon A. , Kostakis P. , Rigopoulos D. , Nicolaidou E. 
Published: January 2020

AbstractBackgroundFew studies have investigated the long‐term outcomes of secukinumab in real‐life psoriasis treatment where diverse patient profiles require a personalized approach.ObjectivesTo determine long‐term performance of secukinumab in moderate‐to‐severe plaque psoriasis, and identify potential clinical factors predictive of sustained optimal response under real‐world conditions.MethodsIn this 78‐week, single‐centre, retrospective study, effectiveness, safety and drug survival of secukinumab were evaluated. Effectiveness data are reported as observed. Co‐primary endpoints were absolute Psoriasis Area and Severity Index (PASI) ≤3 at week 4, 16, 52, 78, and clinical predictors of PASI ≤3 and PASI100 responses at week 52 and 78.ResultsA total of 85 patients (75.3% male; mean age 48.6 years) were included. Absolute PASI ≤3 was achieved in 73% and 83% of patients at week 52 and 78, respectively. PASI 75/90/100 responses at week 52 (71.6%, 50.8%, and 40.3%, respectively) were sustained at week 78 (73.6%, 64.2%, and 45.3%, respectively). Median absolute PASI remained low at week 52/78 (0.9/0.6, respectively), while mean absolute PGA also sustained low (0–1) values after 16–78 weeks. Investigator's Global Assessment 0/1 response rate was maintained by week 52/78 (72/83%, respectively). The drug survival rate of secukinumab at week 78 was 79.1%. Treatment was discontinued in 17.9% of patients after an average of 41.7 weeks, mainly due to loss of effectiveness (10.4%). A total of 27% experienced adverse events, without critical safety concerns. Based on multivariate analysis, advanced body mass index (BMI) and presence of ≥3 comorbidities decreased the chance of achieving PASI ≤3 at week 78 [OR (95% CI) 0.78 (0.64–0.97); P = 0.024, and OR (95% CI) 0.045 (0.002–0.83); P = 0.037, respectively].ConclusionsSecukinumab showed consistently high effectiveness in this real‐life cohort, with an acceptable safety profile. Over time, persistence of PASI ≤3 response appears to be lower in patients with high BMI or multiple comorbidities.
Kaposi sarcoma among people living with HIV in the French DAT’AIDS cohort between 2010 and 2015
Authors: Poizot‐Martin I. , Obry‐Roguet V. , Duvivier C. , Lions C. , Huleux T. , Jacomet C. , Ferry T. , Cheret A. , Allavena C. , Bani‐Sadr F. , Palich R. , Cabié A. , Fresard A. , Pugliese P. , Delobel P. , Lamaury I. , Hustache‐Mathieu L. , Brégigeon S. , Makinson A. , Rey D. ,   The Dat'AIDS study group
Published: January 2020

AbstractBackgroundAlthough antiretroviral therapy (ART) has reduced the risk of Kaposi sarcoma (KS), KS cases still occur in HIV‐infected people.ObjectiveTo describe all KS cases observed between 2010 and 2015 in a country with high ART coverage.MethodsRetrospective study using longitudinal data from 44 642 patients in the French Dat’AIDS multicenter cohort. Patients’ characteristics were described at KS diagnosis according to ART exposure and to HIV‐plasma viral load (HIV‐pVL) (≤50 or >50) copies/mL.ResultsAmong the 209 KS cases diagnosed during the study period, 33.2% occurred in ART naïve patients, 17.3% in ART‐experienced patients and 49.5% in patients on ART, of whom 23% for more than 6 months. Among these patients, 24 (11.5%) had HIV‐pVL ≤50 cp/mL, and 16 (66%) were treated with a boosted‐PI‐based regimen. The distribution of KS localization did not differ by ART status nor by year of diagnosis.LimitationsData on human herpesvirus 8, treatment modalities for KS and response rate were not collected.ConclusionHalf of KS cases observed in the study period occurred in patients not on ART, reflecting the persistence of late HIV diagnosis. Factors associated with KS in patients on ART with HIV‐pVL ≤50 cp/mL remain to be explored.
Drug survival in patients with psoriasis is associated with the availability of biologic medications
Authors: Shalom G. , Cohen A.D. , Feldhamer I. , Comaneshter D. , Freud T. , Pavlovsky L. 
Published: January 2020

AbstractBackgroundDrug survival rates in patients with psoriasis had been described extensively. Different survival rates of TNF‐α inhibitors (TNFIs), ustekinumab and secukinumab were reported.ObjectivesTo investigate drug survival rates of TNFIs, ustekinumab and secukinumab, with particular emphasis on the difference between ustekinumab and secukinumab.MethodsSurvival analysis was performed in patients with moderate‐to‐severe psoriasis who received adalimumab, infliximab, etanercept, ustekinumab and secukinumab treatment in 2002–2018, using the Clalit Health Services database. Stratified analysis was performed according to biologic treatment lines. Multivariate analysis was performed adjusting for demographic variables, calendar year, metabolic syndrome, psoriatic arthritis, biologic treatment line, biologic naivety, co‐administration of oral treatments and previous oral systemic treatment exposure.ResultsAmong 1459 patients treated with 3070 biologic medication courses, ustekinumab had a significantly higher crude survival as compared with TNFIs and secukinumab. The mean drug survival of ustekinumab, adalimumab, etanercept, infliximab and secukinumab was 43.5 (CI: 39.7–47.2), 38.2 (CI: 34.8–41), 33.9 (CI: 30.8–37.1), 28.2 (CI: 22.5–33.8) and 17.1 (CI: 15.6–18.6) months, respectively, with significant statistical differences for all comparisons (P < 0.001). The differences between ustekinumab and secukinumab were not significant following adjustment to factors that included treatment line (hazard rate 1.16, CI: 0.93–1.43).ConclusionDifferent drug survival rates between ustekinumab and secukinumab are determined by the treatment line and calendar year, reflecting the availability of biologic medications, and not only by the biologic attributes of each medication.