bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simplified automatic fault detection in wind turbine induction generators
Authors: Brigham Katharine , Zappalá Donatella , Crabtree Christopher J. , Donaghy‐Spargo Christopher 
Published: January 2020

AbstractThis paper presents a simplified automated fault detection scheme for wind turbine induction generators with rotor electrical asymmetries. Fault indicators developed in previous works have made use of the presence of significant spectral peaks in the upper sidebands of the supply frequency harmonics; however, the specific location of these peaks may shift depending on the wind turbine speed. As wind turbines tend to operate under variable speed conditions, it may be difficult to predict where these fault‐related peaks will occur. To accommodate for variable speeds and resulting shifting frequency peak locations, previous works have introduced methods to identify or track the relevant frequencies, which necessitates an additional set of processing algorithms to locate these fault‐related peaks prior to any fault analysis. In this work, a simplified method is proposed to instead bypass the issue of variable speed (and shifting frequency peaks) by introducing a set of bandpass filters that encompass the ranges in which the peaks are expected to occur. These filters are designed to capture the fault‐related spectral information to train a classifier for automatic fault detection, regardless of the specific location of the peaks. Initial experimental results show that this approach is robust against variable speeds and further shows good generalizability in being able to detect faults at speeds and conditions that were not presented during training. After training and tuning the proposed fault detection system, the system was tested on “unseen” data and yielded a high classification accuracy of 97.4%, demonstrating the efficacy of the proposed approach.
Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation
Authors: Schäbler Stefan , Amatobi Kelechi M. , Horn Melanie , Rieger Dirk , Helfrich-Förster Charlotte , Mueller Martin J. , Wegener Christian , Fekete Agnes 
Published: January 2020

AbstractThe fruit fly Drosophila is a prime model in circadian research, but still little is known about its circadian regulation of metabolism. Daily rhythmicity in levels of several metabolites has been found, but knowledge about hydrophobic metabolites is limited. We here compared metabolite levels including lipids between period01 (per01) clock mutants and Canton-S wildtype (WTCS) flies in an isogenic and non-isogenic background using LC–MS. In the non-isogenic background, metabolites with differing levels comprised essential amino acids, kynurenines, pterinates, glycero(phospho)lipids, and fatty acid esters. Notably, detectable diacylglycerols (DAG) and acylcarnitines (AC), involved in lipid metabolism, showed lower levels in per01 mutants. Most of these differences disappeared in the isogenic background, yet the level differences for AC as well as DAG were consistent for fly bodies. AC levels were dependent on the time of day in WTCS in phase with food consumption under LD conditions, while DAGs showed weak daily oscillations. Two short-chain ACs continued to cycle even in constant darkness. per01 mutants in LD showed no or very weak diel AC oscillations out of phase with feeding activity. The low levels of DAGs and ACs in per01 did not correlate with lower total food consumption, body mass or weight. Clock mutant flies showed higher sensitivity to starvation independent of their background-dependent activity level. Our results suggest that neither feeding, energy storage nor mobilisation is significantly affected in per01 mutants, but point towards impaired mitochondrial activity, supported by upregulation of the mitochondrial stress marker 4EBP in the clock mutants.
Multiple criteria decision making based on weighted Archimedean power partitioned Bonferroni aggregation operators of generalised orthopair membership grades
Authors: Qin Yuchu , Qi Qunfen , Scott Paul J. , Jiang Xiangqian 
Published: January 2020

AbstractIn this paper, a multiple criteria decision making (MCDM) method based on weighted Archimedean power partitioned Bonferroni aggregation operators of generalised orthopair membership grades (GOMGs) is proposed. Bonferroni mean operator, geometric Bonferroni mean operator, power average operator, partitioned average operator, and Archimedean T-norm and T-conorm operations are introduced into generalised orthopair fuzzy sets to develop the Bonferroni aggregation operators. Their formal definitions are provided, and generalised and specific expressions are constructed. On the basis of the specific operators, a method for solving the MCDM problems based on GOMGs is designed. The working process, characteristics, and feasibility of the method are, respectively, demonstrated via a numerical example, a qualitative comparison at the aspect of characteristics, and a quantitative comparison using the example as benchmark. The demonstration results show that the proposed method is feasible that has desirable generality and flexibility in the aggregation of criterion values and concurrently has the capabilities to deal with the heterogeneous interrelationships of criteria, reduce the negative influence of biased criterion values, and capture the risk attitudes of decision makers.
On Hölder regularity of the singular set of energy minimizing harmonic maps into closed manifolds
Authors: Miśkiewicz Michał 
Published: January 2020

AbstractEnergy minimizing harmonic maps between manifolds are known to be smooth outside a rectifiable set of codimension 3, called the singular set. The possibility that this set is not a manifold, but has arbitrarily many small gaps in it, is not excluded in general. Here we prove that some part of the singular set—characterized by topological and analytic properties of tangent maps—is a topological manifold. In the special case of maps into the sphere $${\mathbb S}^2$$S2, we conclude that the whole top-dimensional part of the singular set is a manifold—this generalizes a similar result in four-dimensional domains, due to Hardt and Lin.
Effects of pay-for-performance on prescription of hypertension drugs among public and private primary care providers in Sweden
Authors: Ellegård Lina Maria 
Published: January 2020

AbstractThis study exploits policy reforms in Swedish primary care to examine the effect of pay-for-performance (P4P) on compliance with hypertension drug guidelines among public and private health care providers. Using provider-level outcome data for 2005–2013 from the Swedish Prescription Register, providers in regions using P4P were compared to providers in other regions in a difference-in-differences analysis. The results indicate that P4P improved guideline compliance regarding prescription of angiotensin converting enzyme inhibitors and angiotensin receptor blockers. The effect was mainly driven by private providers, suggesting that policy makers should take ownership into account when designing incentives for health care providers.
A Posteriori Error Analysis for Implicit–Explicit hp-Discontinuous Galerkin Timestepping Methods for Semilinear Parabolic Problems
Authors: Cangiani Andrea , Georgoulis Emmanuil H. , Sabawi Mohammad 
Published: January 2020

AbstractA posteriori error estimates in the $$L_\infty (\mathcal {H})$$L∞(H)- and $$L_2(\mathcal {V})$$L2(V)-norms are derived for fully-discrete space–time methods discretising semilinear parabolic problems; here $$ \mathcal {V}\hookrightarrow \mathcal {H}\hookrightarrow \mathcal {V}^*$$V↪H↪V∗ denotes a Gelfand triple for an evolution partial differential equation problem. In particular, an implicit–explicit variable order (hp-version) discontinuous Galerkin timestepping scheme is employed, in conjunction with conforming finite element discretisation in space. The nonlinear reaction is treated explicitly, while the linear spatial operator is treated implicitly, allowing for time-marching without the need to solve a nonlinear system per timestep. The main tool in obtaining these error estimates is a recent space–time reconstruction proposed in Georgoulis et al. (A posteriori error bounds for fully-discrete hp-discontinuous Galerkin timestepping methods for parabolic problems, Submitted for publication) for linear parabolic problems, which is now extended to semilinear problems via a non-standard continuation argument. Some numerical investigations are also included highlighting the optimality of the proposed a posteriori bounds.
A Functional CLT for Partial Traces of Random Matrices
Authors: Nagel Jan 
Published: January 2020

AbstractIn this paper, we show a functional central limit theorem for the sum of the first $$\lfloor t n \rfloor $$

⌊
t
n
⌋

diagonal elements of f(Z) as a function in t, for Z a random real symmetric or complex Hermitian $$n\times n$$

n
×
n

matrix. The result holds for orthogonal or unitarily invariant distributions of Z, in the cases when the linear eigenvalue statistic $${\text {tr}}f(Z)$$

tr
f
(
Z
)

satisfies a central limit theorem (CLT). The limit process interpolates between the fluctuations of individual matrix elements as $$f(Z)_{1,1}$$

f

(
Z
)

1
,
1

and of the linear eigenvalue statistic. It can also be seen as a functional CLT for processes of randomly weighted measures.
Effect of stabilizers and nitrogen content on thermal properties of nitrocellulose granules
Authors: Cieślak Katarzyna , Gańczyk-Specjalska Katarzyna , Drożdżewska-Szymańska Katarzyna , Uszyński Michał 
Published: January 2020

AbstractThe granules containing nitrogen of various content (12.2–13.3%) and stabilizers (centralite I, centralite II, akardite II, triphenylamine) were obtained in laboratory scale, and the study of their physicochemical and thermal properties was conducted. It has been observed that the helium density of granules depends on the degree of gelling of nitrocellulose by the stabilizer as well as the lack of effect of the stabilizer type on the heat of combustion value. In turn, the heat of combustion depends on the content of nitrogen in nitrocellulose. Granules of 13.3% N nitrocellulose were characterized by a more rapidly developing thermal decomposition than the granules containing 12.2 and 12.9% N nitrocellulose. The maximum temperature of decomposition shifts toward higher temperatures (from 207.6 to 209.8 °C) with decreasing nitrogen content in nitrocellulose for granules containing triphenylamine as a stabilizer. All values of heat generation rate obtained for granules with triphenylamine were lower than the respective rates for granules with centralite I. Thermal properties and chemical stability of granules containing triphenylamine have better properties, when compared to other examined stabilizers. On the basis of differential scanning calorimetry and thermogravimetry, kinetic parameters were calculated by means of Ozawa–Flynn–Wall analysis. The effect of stabilizers and nitrogen content on kinetic parameters was determined. The kinetic model of thermal decomposition of granules was adjusted—the best fit was nth-order reaction with autocatalysis. The activation energy of thermal decomposition process according to the adopted chemical reaction model increases from 190 to 239 kJ mol−1 with increasing nitrogen content in the granulate.
The Pharmacotherapy of Persistent Genital Arousal Disorder
Authors: Kruger Tillmann H. C. , Schippert Cordula , Meyer Bernhard 
Published: January 2020

Abstract
Purpose of Review
Persistent genital arousal disorder (PGAD) is a rare, yet debilitating, disease, which was first described at the beginning of this century and has not yet been considered by the ICD-10 or DSM-5. Since affected subjects usually suffer tremendously, this review aims at offering an overview of pharmacological approaches to treat this disorder.

Recent Findings
Until now, no randomised placebo-controlled clinical trials have been conducted on PGAD, and the international registries have not recorded any ongoing trials. Current knowledge on pharmacological options for the treatment of PGAD relies mainly on case reports/case series. Most importantly, there is evidence that some drugs such as SSRIs and SNRIs might induce or worsen PGAD.

Summary
Knowledge on pharmacological treatment options for PGAD is not yet evidence-based, while some reports even assume an induction of PGAD by serotonergic antidepressants. Nevertheless, practitioners should be aware of PGAD and carefully discuss with the patient an individual treatment trial by considering the experience up to now.
Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management
Authors: Fone Kevin C.F. , Watson David J.G. , Billiras Rodolphe I. , Sicard Dorothee I. , Dekeyne Anne , Rivet Jean-Michel , Gobert Alain , Millan Mark J. 
Published: January 2020

AbstractFrontocortical NMDA receptors are pivotal in regulating cognition and mood, are hypofunctional in schizophrenia, and may contribute to autistic spectrum disorders. Despite extensive interest in agents potentiating activity at the co-agonist glycine modulatory site, few comparative functional studies exist. This study systematically compared the actions of the glycine reuptake inhibitors, sarcosine (40–200 mg/kg) and ORG24598 (0.63–5 mg/kg), the agonists, glycine (40–800 mg/kg), and D-serine (10–160 mg/kg) and the partial agonists, S18841 (2.5 mg/kg s.c.) and D-cycloserine (2.5–40 mg/kg) that all dose-dependently prevented scopolamine disruption of social recognition in adult rats. Over similar dose ranges, they also prevented a delay-induced impairment of novel object recognition (NOR). Glycine reuptake inhibitors specifically elevated glycine but not D-serine levels in rat prefrontal cortical (PFC) microdialysates, while glycine and D-serine markedly increased levels of glycine and D-serine, respectively. D-Cycloserine slightly elevated D-serine levels. Conversely, S18841 exerted no influence on glycine, D-serine, other amino acids, monamines, or acetylcholine. Reversal of NOR deficits by systemic S18841 was prevented by the NMDA receptor antagonist, CPP (20 mg/kg), and the glycine modulatory site antagonist, L701,324 (10 mg/kg). S18841 blocked deficits in NOR following microinjection into the PFC (2.5–10 μg/side) but not the striatum. Finally, in rats socially isolated from weaning (a neurodevelopmental model of schizophrenia), S18841 (2.5 and 10 mg/kg s.c.) reversed impairment of NOR and contextual fear-motivated learning without altering isolation-induced hyperactivity. In conclusion, despite contrasting neurochemical profiles, partial glycine site agonists and glycine reuptake inhibitors exhibit comparable pro-cognitive effects in rats of potential relevance to treatment of schizophrenia and other brain disorders where cognitive performance is impaired.
Never good enough: The relation between the impostor phenomenon and multidimensional perfectionism
Authors: Pannhausen Sophie , Klug Kristina , Rohrmann Sonja 
Published: January 2020

AbstractThe Impostor Phenomenon can be described as the tendency to attribute professional success not to one’s own abilities but to excessive effort or fortunate external circumstances. Individuals strongly experiencing those tendencies fear that one day they will be exposed as “impostors” as soon as their alleged incompetence can no longer be concealed. Typical characteristics of the Impostor Phenomenon outlined by Clance (1985) show a remarkable conceptual similarity to the personality construct of perfectionism. Thus, the present study aimed at investigating how the Impostor Phenomenon is related to various facets of dispositional perfectionism with respect to predominant conceptualizations of perfectionism by Frost et al. (1990), Hewitt and Flett (1991), as well as their combination within the bifactor model of Perfectionistic Strivings and Perfectionistic Concerns (Frost et al. 1993). A total of N = 274 individuals participated in an online survey including the Impostor Phenomenon Scale (CIPS; Clance 1988), the Frost Multidimensional Perfectionism Scale (FMPS; Frost et al. 1990), and the Hewitt und Flett Multidimensional Perfectionism Scale (MPS short form; Hewitt et al. 2008). Hierarchical regression analyses were conducted to determine the differential contributions of perfectionism dimensions and factors in predicting the Impostor Phenomenon. The perfectionism dimensions Doubts about Actions, Concern over Mistakes and Socially prescribed Perfectionism appeared to be efficient predictors of the Impostor Phenomenon. Contrary to Perfectionistic Strivings, Perfectionistic Concerns as a maladaptive perfectionism factor strongly contributed to the prediction of the Impostor Phenomenon. Theoretical and practical implications of the associations between the Impostor Phenomenon and multidimensional perfectionism are discussed.
Detoxifying deoxynivalenol (DON)-contaminated feedstuff: consequences of sodium sulphite (SoS) treatment on performance and blood parameters in fattening pigs
Authors: Bahrenthien L. , Kluess J. , Berk A. , Kersten S. , Saltzmann J. , Hüther L. , Schatzmayr D. , Schwartz-Zimmermann H. E. , Zeyner A. , Dänicke S. 
Published: January 2020

AbstractA 10-week feeding experiment was carried out examining the effects of deoxynivalenol (DON)-contaminated maize treated with different sodium sulphite (SoS) concentrations on performance, health and DON-plasma concentrations in fattening pigs. Two maize batches were used: background-contaminated (CON, 0.73 mg/kg maize) and Fusarium-toxin contaminated (DON, 44.45 mg/kg maize) maize. Both were wet preserved at 20% moisture content, with one of three (0.0, 2.5, 5.0 g/kg maize) sodium sulphite concentrations and propionic acid (15%). Each maize batch was then mixed into a barley-wheat-based diet at a proportion of 10%, resulting in the following 6 feeding groups: CON− (CON + 0.0 g SoS/kg maize), CON2.5 (CON + 2.5 g SoS/kg maize), CON5.0 (CON + 5.0 g SoS/kg maize), DON- (DON + 0.0 g SoS/kg maize), DON2.5 (DON + 2.5 g SoS/kg maize) and DON5.0 (DON + 5.0 g SoS/kg maize). Dietary DON concentration was reduced by ~ 36% in group DON2.5 and ~ 63% in group DON5.0. There was no impact on ZEN concentration in the diets due to SoS treatment. Pigs receiving diet DON- showed markedly lower feed intake (FI) compared to those fed the control diets. With SoS-treatment of maize, FI of pigs fed the DON diet (DON5.0: 3.35 kg/d) were comparable to that control (CON−: 3.30 kg/day), and these effects were also reflected in live weight gain. There were some effects of SoS, DON or their interaction on serum urea, cholesterol and albumin, but always within the physiological range and thus likely negligible. SoS wet preservation of Fusarium-toxin contaminated maize successfully detoxified DON to its innocuous sulfonates, thus restoring impaired performance in fatteners.
Flexible Gas Sensor Printed on a Polymer Substrate for Sub-ppm Acetone Detection
Authors: Andrysiewicz W. , Krzeminski J. , Skarżynski K. , Marszalek K. , Sloma M. , Rydosz A. 
Published: January 2020

Abstract
Gas sensors are widely used in many industrial and home applications. There is therefore continued need to develop novel gas sensor substrates which provide good mechanical and electrical stability, and good flexibility in comparison with the conventional alumina and silicon-based materials. In this paper, we present the experimental results on flexible gas sensors based on the Kapton foil and alumina substrate covered by copper oxide as a gas-sensitive layer. These sensors exhibited good mechanical stability and gas-sensing characteristics. The Kapton-based CuO gas sensors were tested under exposure to acetone in the 0.05–1.25 ppm range (150 °C, 50%RH). The results confirmed that sensors deposited on the flexible substrate such as Kapton can be used in the exhaled breath analyzers dedicated to diabetes biomarker detection or other applications for which the elastic substrate is needed.

Graphic Abstract
Diagnosis of Amyloidosis: A Survey of Current Awareness and Clinical Challenges Among Cardiologists in Switzerland
Authors: Mircsof Dennis 
Published: January 2020

Abstract
Introduction
Transthyretin amyloidosis (ATTR) is a progressive disease in which amyloid fibril deposition disrupts tissue structure and organ function. Many patients with ATTR present with cardiac involvement; recent studies indicate that ATTR prevalence is higher than expected in patients with certain heart conditions. Although long delays to diagnosis are common, recent treatment advances have made timely diagnosis critical to ensure appropriate patient management. Despite clinical guideline updates, it remains unclear how these are being implemented in routine patient care.

Methods
We performed a survey of practicing cardiologists in Switzerland to assess their knowledge of ATTR and current clinical practice.

Results
Overall, 72 cardiologists completed the questionnaire in a face-to-face interview (n = 16) or online (n = 56). Key findings highlighted wide variation in cardiologists’ knowledge about the diagnostic tests required for a differential diagnosis of ATTR. In particular, many cardiologists lacked familiarity with radiolabeled bone scintigraphy, an important non-invasive test that is part of the diagnostic algorithm for ATTR. Another challenge in diagnosing amyloidosis appears to be general awareness of ATTR among cardiologists.

Conclusions
Survey results highlight that cardiologists in Switzerland would benefit from information on the latest advances in ATTR to support them in screening heart failure patients and ensure that patients benefit from treatment advances.
Biosynthesis of Flower-Shaped CuO Nanostructures and Their Photocatalytic and Antibacterial Activities
Authors: Siddiqui Hafsa , Qureshi M. S. , Haque Fozia Zia 
Published: January 2020

AbstractCopper oxide nanoflowers (CuO-NFs) have been synthesized through a novel green route using Tulsi leaves-extracted eugenol (4-allyl-2-methoxyphenol) as reducing agent. Characterizations results reveal the growth of crystalline single-phase CuO-NFs with monoclinic structure. The prepared CuO-NFs can effectively degrade methylene blue with 90% efficiency. They also show strong barrier against E. coli (27 ± 2 mm) at the concentration of 100 µg mL−1, while at the concentration of 25 µg mL−1 weak barrier has been found against all examined bacterial organisms. The results provide important evidence that CuO-NFs have sustainable performance in methylene blue degradation as well as bacterial organisms.
Biosimilars in der Gastroenterologie
Authors: Dejaco Clemens , Novacek Gottfried , Haas Thomas , Fuchssteiner Harry , Moschen Alexander , Högenauer Christoph , Petritsch Wolfgang 
Published: January 2020

ZusammenfassungBiologika nehmen eine herausragende Rolle in der Therapie chronisch-entzündlicher Darmerkrankungen (CED) ein. Diese aus lebenden Zellen biotechnologisch hergestellten Antikörper (Ak) ermöglichen zunehmend selektive antientzündliche Behandlungsansätze, wobei deren Produktion und Zulassung einem komplexen und kostenintensiven Entwicklungsprozess unterliegen. Mit Patentablauf einzelner Biologika kommen seit einigen Jahren nun zunehmend Biosimilars, ebenso biotechnologisch produzierte Nachfolgepräparate, auf den Markt und führen zu einer zunehmenden Präparatevielfalt bei sinkenden Kosten für das Gesundheitssystems. Das vorliegende Positionspapier der Arbeitsgruppe (AG) CED der Österreichischen Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH) versucht mit dieser Entwicklung aufkommende Fragen betreffend Wirksamkeit, Sicherheit, Präparatewechsel (Switch) und Verschreibungsgebarung zu beantworten, um eine höchstmögliche Patientensicherheit auch zukünftig zu gewährleisten.