bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dilemma of the differential diagnosis of hilar cholangiocarcinoma and benign diseases: a single-center retrospective study
Authors: Pang Liwei , Hu Shangzhi , Dai Wanlin , Wu Shuodong , Kong Jing 
Published: November 2020

AbstractHilar cholangiocarcinoma (HCCA), which lacks specific clinical manifestations, remains very difficult to distinguish from benign disease. This distinction is further complicated by the complex hilar anatomy. We conducted the present study to evaluate the differential diagnosis of these conditions. Sixty-five patients underwent resection surgery for suspected HCCA between January 2011 and October 2018. Institutional Review Board of Shengjing hospital agreed this study and all participants sign an informed consent document prior to participation in a research study. Following a postoperative pathology analysis, all patients were divided into two groups: malignant group (54 patients with HCCA) and benign group (11 cases with benign lesions). Compared with the benign group, the malignant group had a significantly higher median age and serum CA19-9, CEA, ALT, BILT and BILD levels (P &lt; 0.05). In contrast, the groups did not differ significantly in terms of the sex distribution, clinical manifestations, serum levels of AST and ALKP, and imaging findings. In a receiver operating characteristic curve analysis, we identified a CA19-9 cutoff point of 233.15 U/ml for the differential diagnosis and CEA cutoff point of 2.98 ng/ml for the differential diagnosis. The differential diagnosis of HCCA and benign hilar lesions remains difficult. However, we found that patients with HCCA tended to have an older age at onset and higher serum levels of CA19-9, CEA, BILT, ALT and BILD. Furthermore, patients with a serum CA19-9 level &gt;233.15 U/ml and CEA level &gt;2.98 ng/ml are more likely to have malignant disease.
Spatial Attention in Serial Order Working Memory: An EEG Study
Authors: Rasoulzadeh Vesal , Sahan Muhammet Ikbal , van Dijck Jean-Philippe , Abrahamse Elger , Marzecova Anna , Verguts Tom , Fias Wim 
Published: November 2020

Abstract
Theoretical models explaining serial order processing link order information to specified position markers. However, the precise characteristics of position marking have remained largely elusive. Recent studies have shown that space is involved in marking serial position of items in verbal working memory (WM). Furthermore, it has been suggested, but not proven, that accessing these items involves horizontal shifts of spatial attention. We used continuous electroencephalography recordings to show that memory search in serial order verbal WM involves spatial attention processes that share the same electrophysiological signatures as those operating on the visuospatial WM and external space. Accessing an item from a sequence in verbal WM induced posterior “early directing attention negativity” and “anterior directing attention negativity” contralateral to the position of the item in mental space (i.e., begin items on the left; end items on the right). In the frequency domain, we observed posterior alpha suppression contralateral to the position of the item. Our results provide clear evidence for the involvement of spatial attention in retrieving serial information from verbal WM. Implications for WM models are discussed.
Staphylococcus aureusSkin and Soft Tissue Infection Recurrence Rates in Outpatients: A Retrospective Database Study at 3 US Medical Centers
Authors: Vella Venanzio , Galgani Ilaria , Polito Letizia , Arora Ashwani Kumar , Creech C Buddy , David Michael Z , Lowy Franklin D , Macesic Nenad , Ridgway Jessica P , Uhlemann Anne-Catrin , Bagnoli Fabio 
Published: November 2020

AbstractBackgroundStaphylococcus aureus skin and soft tissue infections (SA-SSTIs) are common in healthcare and community settings, and recurrences occur at variable frequency, even after successful initial treatment. Knowing the exact burden and timing of recurrent disease is critical to planning and evaluating interventions to prevent recurrent SSTIs.MethodsIn this retrospective study, SSTI cases in patients aged ≥18 years at 3 US medical centers (Columbia, Chicago, Vanderbilt) between 2006 and 2016 were analyzed according to a biennial cohort design. Index SSTIs (with or without key comorbidities), either microbiologically confirmed to be SA-SSTI or not microbiologically tested (NMT-SSTI), were recorded within 1 calendar year and followed up for 12 months for recurrent infections. The number of index cases, proportion of index cases with ≥1 recurrence(s), time to first recurrence, and number of recurrences were collected for both SA-SSTI and NMT-SSTI events.ResultsIn the most recent cohorts, 4755 SSTI cases were reported at Columbia, 2873 at Chicago, and 6433 at Vanderbilt. Of these, 452, 153, and 354 cases were confirmed to be due to S. aureus. Most cases were reported in patients without key comorbidities. Across centers, 16.4%–19.0% (SA-SSTI) and 11.0%–19.2% (NMT-SSTI) of index cases had ≥1 recurrence(s). In patients without key comorbidities, more than 60% of index SSTIs with recurrences had only 1 recurrence, half of which occurred in the first 3 months following primary infection.ConclusionsSA-SSTI recurrences are common among healthy adults and occur in at least 1 in 6 individuals during the 1 year following the primary event.
Cost-Consequence Analysis of Single-Dose Dalbavancin Versus Standard of Care for the Treatment of Acute Bacterial Skin and Skin Structure Infections in a Multisite Healthcare System
Authors: Gonzalez Julia , Andrade Diana Carolina , Niu JianLi 
Published: November 2020

Abstract

Background
Acute bacterial skin and skin structure infections (ABSSSIs) are common infectious diseases that cause a significant economic burden on the healthcare system. This study aimed to compare the cost-effectiveness of dalbavancin vs standard of care (SoC) in the treatment of ABSSSI in a community-based healthcare system.

Methods
This was a retrospective study of adult patients with ABSSSI treated with dalbavancin or SoC during a 27-month period. Patients were matched based on age and body mass index. The primary outcome was average net cost of care to the healthcare system per patient, calculated as the difference between reimbursement payments and the total cost to provide care to the patient. The secondary outcome was proportion of cases successfully treated, defined as no ABSSSI-related readmission within 30 days after the initiation of treatment.

Results
Of the 418 matched patients, 209 received SoC and 209 received dalbavancin. The average total cost of care per patient was greater with dalbavancin vs SoC ($4770 vs $2709, P &lt; .0001). The average reimbursement per patient was $3084 with dalbavancin vs $2633 SoC (P = .527). The net cost, calculated as revenue minus total cost, was $1685 with dalbavancin vs $75 with SoC (P = .013). The overall treatment success rate was 74% with dalbavancin vs 85% with SoC (P = .004).

Conclusions
Dalbavancin was more costly than SoC for the treatment of ABSSSI, with a higher 30-day readmission rate. Dalbavancin does not offer an economic or efficacy advantage.
Myocardial Injury and the Release of Troponins I and T in the Blood of Patients
Authors: Katrukha Ivan A , Katrukha Alexey G 
Published: November 2020

Abstract

Background
Cardiac troponin I (cTnI) and cTnT are the established biomarkers of cardiomyocyte damage and the recommended biomarkers for the diagnosis of acute myocardial infarction (MI). High-sensitivity immunochemical diagnostic systems are able to measure the cTn concentrations in the blood of a majority of healthy people. At the same time, the concentration of cTn may be increased not only after MI but also because of other pathologies that might affect myocardium. This effect reduces the clinical specificity of cTn for MI and may complicate the diagnosis.

Content
This review summarizes the existing information regarding the causes and mechanisms that lead to the increase of cTn concentration in blood and the forms of cTn that are present in circulation after MI or other types of myocardial injury.

Summary
Different etiologies of disease associated with increases of cTn above the 99th percentile and various mechanisms of troponin release from myocardium could result in the appearance of different forms of cTn in blood and provide the first clinical evidence of injury. Additional research is needed for the careful characterization of cTn forms that are present in the blood in different clinical settings. That knowledge may lead to the development of immunochemical systems that would differentiate certain forms of troponins and possibly certain types of cardiac disease.
Networks with degree–degree correlations are special cases of the edge-coloured random graph
Authors: Balogh Sámuel G , Palla Gergely , Kryven Ivan 
Published: November 2020

Abstract
In complex networks, the degrees of adjacent nodes may often appear dependent—which presents a modelling challenge. We present a working framework for studying networks with an arbitrary joint distribution for the degrees of adjacent nodes by showing that such networks are a special case of edge-coloured random graphs. We use this mapping to study bond percolation in networks with assortative mixing and show that, unlike in networks with independent degrees, the sizes of connected components may feature unexpected sensitivity to perturbations in the degree distribution. The results also indicate that degree–degree dependencies may feature a vanishing percolation threshold even when the second moment of the degree distribution is finite. These results may be used to design artificial networks that efficiently withstand link failures and indicate the possibility of super spreading in networks without clearly distinct hubs.
Limited Scope Risk Assessment for Nontarget Ground-Dwelling Arthropods From Systemic Insecticide Applications to Young Pines
Authors: Cassidy V C , McCarty E P , Asaro C 
Published: November 2020

AbstractThe Nantucket pine tip moth (NPTM) [Rhyacionia frustrana (Comstock)], a native regeneration pest on young loblolly pines (Pinus taeda L.), negatively impacts pine growth. An emerging management approach is to apply systemic insecticides to seedlings to reduce NPTM damage. These systemic insecticide applications generally occur once, perhaps twice, during the first few years of loblolly pine growth. However, these applications could lead to unintended environmental consequences to nontarget organisms. The purpose of this study was to assess potential nontarget effects from four systemic insecticide applications by assessing ground-dwelling arthropod trap catch, with a focus on collembolan trap catch and genera richness. Loblolly seedlings (24 seedlings per plot) at three sites in southeast Georgia were treated with either chlorantraniliprole, dinotefuran, fipronil, or imidacloprid or left untreated as a control. Arthropods were collected with pitfall traps that were deployed for 5 d in July, August, and September 2019, 7–9 mo after treatment. Ground-dwelling arthropod trap catch, arthropod order trap catch, collembolan trap catch, and collembolan genera richness did not vary among insecticide treatments and the untreated control in this mid-term insecticide risk assessment. While no significant effects of insecticide treatment were observed, ground-dwelling arthropod trap catch, collembolan trap catch, and collembolan genera richness differed among collection times. This study was the first of its kind in a young pine stand setting and is an important first step to understanding risk in these settings. Information on nontarget risks of management practices informs growers of the level of environmental risk associated with systemic insecticides.
Socio-Economic Family Background and Adult Children’s Health in Germany: The Role of Intergenerational Transmission of Education
Authors: Arránz Becker Oliver , Loter Katharina 
Published: November 2020

AbstractThis study examines consequences of parental education for adult children’s physical and mental health using panel data from the German Socio-Economic Panel study. Based on random-effects growth curve models (N = 15,144 West German respondents born between 1925 and 1998 aged 18–80), we estimate gender-, age-, and cohort-specific trajectories of physical and mental health components of the SF-12 questionnaire for low and high parental education measured biennially from 2002 to 2018. Findings suggest more persistent effects of parental education on physical than mental health. In particular, both daughters and sons of the lower educated group of parents (with neither parent qualified for university) exhibit markedly poorer physical health over the whole life course and worse mental health in mid-life and later life than those of higher educated parents. Thus, children’s health gradients conditional on parental education tend to widen with increasing age. Once children’s educational attainment is held constant, effects of parental education on children’s health mostly vanish. This suggests that in the strongly stratified West German context with its rather low social mobility, intergenerational transmission of education, which, according to our analyses, has been declining among younger cohorts, contributes to cementing long-term health inequalities across the life course.
Risk of arrhythmias after myocardial infarction in patients with left ventricular systolic dysfunction according to mode of revascularization: a Cardiac Arrhythmias and RIsk Stratification after Myocardial infArction (CARISMA) substudy
Authors: Thomsen Anna F , Jacobsen Peter Karl , Køber Lars , Joergensen Rikke Moerch , Huikuri Heikki V , Bloch Thomsen Poul Erik , Jacobsen Uffe G , Jøns Christian 
Published: November 2020

Abstract

Aims
The Cardiac Arrhythmias and RIsk Stratification after Myocardial infArction (CARISMA) study was an observational trial including 312 patients with acute myocardial infarction (MI) and left ventricular ejection fraction (LVEF) &lt;40%. Primary percutaneous intervention (pPCI) was introduced 2 years after start of the enrolment, dividing the population into two groups: pre- and post-pPCI. This substudy sought to describe the influence of the mode of revascularization on long-term risk of new-onset atrial fibrillation (AF), bradyarrhythmia, and ventricular tachycardia and the subsequent risk of relevant major cardiovascular events (MACE).

Methods and results
The study included the 268 patients without a history of AF. All patients received an implantable cardiac monitor (ICM) and were followed for 2 years. The choice of revascularization was made by the treating team independently of the trial and retrospectively divided into pPCI, subacute PCI, primary thrombolysis, or no revascularization. Endpoints were new-onset arrhythmia and MACE.
A total of 77 patients received no revascularization, whereas 49 received thrombolysis only and 142 received any PCI. The adjusted hazard ratio (HR) for developing any arrhythmia and the subsequently risk of MACE were increased in non-revascularized or thrombolysed patients compared with PCI-patients (any arrhythmia, non-revascularization: HR = 1.7, P = 0.01 and thrombolysis: HR = 1.6, P = 0.05; MACE, non-revascularization: HR = 3.1, P = 0.05 and thrombolysis: HR = 3.1, P = 0.08). All HRs were adjusted for significant baseline and clinically considered covariates and stratified for calendar year.

Conclusion
This study is the first to demonstrate that the long-term risk of arrhythmia documented by an ICM and the subsequent risk of MACE were increased in non-revascularized or thrombolysed patients compared with PCI-patients in a post-MI population with LVEF &lt;40%.
Whole-Genome Transcriptome Analyses of Native Symbionts Reveal Host Coral Genomic Novelties for Establishing Coral–Algae Symbioses
Authors: Yoshioka Yuki , Yamashita Hiroshi , Suzuki Go , Zayasu Yuna , Tada Ipputa , Kanda Miyuki , Satoh Noriyuki , Shoguchi Eiichi , Shinzato Chuya 
Published: November 2020

Abstract
Reef-building corals and photosynthetic, endosymbiotic algae of the family Symbiodiniaceae establish mutualistic relationships that are fundamental to coral biology, enabling coral reefs to support a vast diversity of marine species. Although numerous types of Symbiodiniaceae occur in coral reef environments, Acropora corals select specific types in early life stages. In order to study molecular mechanisms of coral–algal symbioses occurring in nature, we performed whole-genome transcriptomic analyses of Acropora tenuis larvae inoculated with Symbiodinium microadriaticum strains isolated from an Acropora recruit. In order to identify genes specifically involved in symbioses with native symbionts in early life stages, we also investigated transcriptomic responses of Acropora larvae exposed to closely related, nonsymbiotic, and occasionally symbiotic Symbiodinium strains. We found that the number of differentially expressed genes was largest when larvae acquired native symbionts. Repertoires of differentially expressed genes indicated that corals reduced amino acid, sugar, and lipid metabolism, such that metabolic enzymes performing these functions were derived primarily from S. microadriaticum rather than from A. tenuis. Upregulated gene expression of transporters for those metabolites occurred only when coral larvae acquired their natural symbionts, suggesting active utilization of native symbionts by host corals. We also discovered that in Acropora, genes for sugar and amino acid transporters, prosaposin-like, and Notch ligand-like, were upregulated only in response to native symbionts, and included tandemly duplicated genes. Gene duplications in coral genomes may have been essential to establish genomic novelties for coral–algae symbiosis.
Long-Term Residential Care Policy Guidance for Staff to Support Resident Quality of Life
Authors: Hande Mary Jean , Keefe Janice , Taylor Deanne 
Published: November 2020

Abstract

Background and Objectives
Amidst a complex policy landscape, long-term residential care (LTRC) staff must navigate directives to provide safe care while also considering resident-preferred quality of life (QoL) supports, which are sometimes at odds with policy expectations. These tensions are often examined using a deficit-based approach to policy analysis, which highlights policy gaps or demonstrates how what is written creates problems in practice.

Research Design and Methods
This study used an asset-based approach by scanning existing LTRC regulations in 4 Canadian jurisdictions for promising staff-related policy guidance for enhancing resident QoL. A modified objective hermeneutics method was used to determine how 63 existing policy documents might be interpreted to support Kane’s 11 QoL domains.

Results
Analysis revealed regulations that covered all 11 resident QoL domains, albeit with an overemphasis on safety, security, and order. Texts that mentioned other QoL domains often outlined passive or vague roles for staff. However, policy texts were found in all 4 jurisdictions that provided clear language to support staff discretion and flexibility to navigate regulatory tensions and enhance resident QoL.

Discussion and Implications
The existing policy landscape includes promising staff-related LTRC regulation in every jurisdiction under investigation. Newer policies tend to reflect more interpretive approaches to staff flexibility and broader QoL concepts. If interpreted through a resident QoL lens and with the right structural supports, these promising texts offer important counters to the rigidity of LTRC policy landscape and can be leveraged to broaden and enhance QoL effectively for residents in LTRC.
Adaptive venom evolution and toxicity in octopods is driven by extensive novel gene formation, expansion, and loss
Authors: Whitelaw Brooke L , Cooke Ira R , Finn Julian , da Fonseca Rute R , Ritschard Elena A , Gilbert M T P , Simakov Oleg , Strugnell Jan M 
Published: November 2020

Abstract

Background
Cephalopods represent a rich system for investigating the genetic basis underlying organismal novelties. This diverse group of specialized predators has evolved many adaptations including proteinaceous venom. Of particular interest is the blue-ringed octopus genus (Hapalochlaena), which are the only octopods known to store large quantities of the potent neurotoxin, tetrodotoxin, within their tissues and venom gland.

Findings
To reveal genomic correlates of organismal novelties, we conducted a comparative study of 3 octopod genomes, including the Southern blue-ringed octopus (Hapalochlaena maculosa). We present the genome of this species and reveal highly dynamic evolutionary patterns at both non-coding and coding organizational levels. Gene family expansions previously reported in Octopus bimaculoides (e.g., zinc finger and cadherins, both associated with neural functions), as well as formation of novel gene families, dominate the genomic landscape in all octopods. Examination of tissue-specific genes in the posterior salivary gland revealed that expression was dominated by serine proteases in non–tetrodotoxin-bearing octopods, while this family was a minor component in H. maculosa. Moreover, voltage-gated sodium channels in H. maculosa contain a resistance mutation found in pufferfish and garter snakes, which is exclusive to the genus. Analysis of the posterior salivary gland microbiome revealed a diverse array of bacterial species, including genera that can produce tetrodotoxin, suggestive of a possible production source.

Conclusions
We present the first tetrodotoxin-bearing octopod genome H. maculosa, which displays lineage-specific adaptations to tetrodotoxin acquisition. This genome, along with other recently published cephalopod genomes, represents a valuable resource from which future work could advance our understanding of the evolution of genomic novelty in this family.
Stagnant lid convection with temperature-dependent thermal conductivity and the thermal evolution of icy worlds
Authors: Deschamps Frédéric 
Published: November 2020

SUMMARY
Convection is an efficient process to release heat from planetary interiors, but its efficiency depends on the detailed properties of planetary mantles and materials. A property whose impact has not yet been studied extensively is the temperature dependence of thermal conductivity. Because thermal conductivity controls heat fluxes, its variations with temperature may alter heat transfer. Here, I assess qualitatively and quantitatively the influence of temperature-dependent thermal conductivity on stagnant lid convection. Assuming that thermal conductivity varies as the inverse of temperature $(k \propto 1/T)$, which is the case for ice Ih, the main component of outer shells of solar System large icy bodies, I performed numerical simulations of convection in 3-D-Cartesian geometry with top-to-bottom viscosity and conductivity ratios in the ranges 105 ≤ Δη ≤ 108 and 1 ≤ Rk ≤ 10, respectively. These simulations indicate that with increasing Rk, and for given values of the Rayleigh number and Δη, heat flux is reduced by a factor Rk0.82, while the stagnant lid is thickening. These results have implications for the structures and thermal evolutions of large icy bodies, the impact of temperature-dependent conductivity being more important with decreasing surface temperature, Tsurf. The heat fluxes and thermal evolutions obtained with temperature-dependent conductivity are comparable to those obtained with constant conductivity, provided that the conductivity is fixed to its value at the bottom or in the interior of the ice shell, that is, around 2.0–3.0 W m−1 K−1, depending on the body. By contrast, temperature-dependent conductivity leads to thicker stagnant lids, by about a factor 1.6–1.8 at Pluto (Tsurf = 40 K) and a factor 1.2–1.4 at Europa (Tsurf = 100 K), and smaller interior temperatures. Overall, temperature-dependent thermal conductivity therefore provides more accurate descriptions of the thermal evolutions of icy bodies.