bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mindfulness and social identity: Predicting well‐being in a high‐stress environment
Authors: Adarves‐Yorno Inmaculada , Mahdon Michelle , Schueltke Leonie , Koschate‐Reis Miriam , Tarrant Mark 
Published: September 2020

AbstractSocial identity processes and mindfulness are two important predictors of well‐being. Yet, to date, these predictors have been studied independently, within separate research fields. This paper aims to provide an initial integration of these two research fields. Our research was conducted in a context characterized by multiple chronic stressors: A maximum security prison in Kenya. In particular, two studies measured social identification with a mindfulness group and dispositional mindfulness. We investigated the effects of these constructs on three well‐being measures: mental well‐being, resilience (Studies 1 & 2), and reduction of substance use (Study 2). Our results, replicated across two studies (Study 1: N = 82, Study 2: N = 145), revealed that both social identification with the mindfulness group and mindfulness predicted psychological outcomes. Social identification explained variance in mental well‐being and resilience in addition to the variance explained by mindfulness. Study 2 additionally showed that both identification and mindfulness were positively related to a reduction in substance use. However, when examined together, social identification held all the explanatory power, and mindfulness was no longer a significant predictor. From the overall results, we argue that social identity processes can be fruitfully combined with mindfulness in well‐being programs delivered in high‐stress environments such as prisons. Theoretical and practical implications are discussed.
Taxon pulse dynamics, episodic dispersal and host colonization across Beringia drive diversification of a Holarctic tapeworm assemblage
Authors: Haas Genevieve M. S. , Hoberg Eric P. , Cook Joseph A. , Henttonen Heikki , Makarikov Arseny A. , Gallagher Sarah R. , Dokuchaev Nikolai E. , Galbreath Kurt E. 
Published: September 2020

AbstractAimWe test the predictions of the Stockholm Paradigm, a synthesis of eco‐evolutionary theory explaining the nature of faunal assembly, host range and parasite diversification. Faunal diversification and assembly, manifested in patterns of host colonization, co‐adaptation and parasite speciation, are predicted to emerge as a consequence of alternating episodes of ecological disruption and stability. Specifically, for a diverse cestode genus (Arostrilepis), we evaluate the number and direction of Pleistocene dispersal events across Beringia, the number and relative timing of host colonization events and the relationship between host and parasite biogeographic histories and associations through time.LocationBeringia and adjacent temperate to arctic biomes in North America and Eurasia.TaxonArostrilepis (Cyclophyllidea: Hymenolepididae) and its rodent hosts.MethodsMulti‐locus phylogenetic reconstruction and biogeographic ancestral range estimation.ResultsArostrilepis lineages crossed Beringia eastward into North America a minimum of four times and westward into Asia twice in association with temporally disjunct geographic expansions of three major tribes of cricetid rodents (Arvicolini, Myodini, Lemmini). Inferences of ancestral host associations support at least nine instances of host colonization involving shifts from one rodent tribe or family to another. Several previously unrecognized lineages of Arostrilepis are revealed.Main conclusionsConsistent with expectations of the Stockholm Paradigm, episodes of intercontinental dispersal were both frequent in the history of Arostrilepis and preceded a majority of inferred host‐colonization events. Events of historical geographic expansion created numerous opportunities for development of novel host–parasite associations through ecological fitting, as parasites tracked historically conserved resources available across diverse host taxa. Beringia played a major role in shaping rodent/parasite assemblages by mediating dispersal between the northern continents during glacial episodes of the Pleistocene, rather than by serving as a zone of refugial isolation.
Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway
Authors: Hu Rong , Wang Ming‐qing , Liu Ling‐yu , You Hai‐yan , Wu Xiao‐hui , Liu Yang‐yang , Wang Yan‐jing , Lu Lu , Xiao Wei , Wei Lian‐bo 
Published: September 2020

AbstractSkeletal muscle atrophy is a common and serious complication of chronic kidney disease (CKD). Oxidative stress and autophagy are the primary molecular mechanisms involved in muscle atrophy. Calycosin, a major component of Radix astragali, exerts anti‐inflammatory, anti‐oxidative stress and anti‐autophagy effects. We investigated the effects and mechanisms of calycosin on skeletal muscle atrophy in vivo and in vitro. 5/6 nephrectomy (5/6 Nx) rats were used as a model of CKD. We evaluated bodyweight and levels of serum creatinine (SCr), blood urea nitrogen (BUN) and serum albumin (Alb). H&E staining, cell apoptosis, oxidative stress biomarkers, autophagosome and LC3A/B levels were performed and evaluated in skeletal muscle of CKD rat. Calycosin treatment improved bodyweight and renal function, alleviated muscle atrophy (decreased the levels of MuRF1 and MAFbx), increased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) activity and reduced malondialdehyde (MDA) levels in skeletal muscle of CKD rats. Importantly, calycosin reduced autophagosome formation, down‐regulated the expression of LC3A/B and ATG7 through inhibition of AMPK and FOXO3a, and increased SKP2, which resulted in decreased expression of CARM1, H3R17me2a. Similar results were observed in C2C12 cells treated with TNF‐α and calycosin. Our findings showed that calycosin inhibited oxidative stress and autophagy in CKD induced skeletal muscle atrophy and in TNF‐α‐induced C2C12 myotube atrophy, partially by regulating the AMPK/SKP2/CARM1 signalling pathway.
Co‐targeting of lysosome and mitophagy in cancer stem cells with chloroquine analogues and antibiotics
Authors: Al‐Bari Md. Abdul Alim 
Published: September 2020

AbstractThe catabolic autophagy eliminates cytoplasmic components and organelles via lysosomes. Non‐selective bulk autophagy and selective autophagy (mitophagy) are linked in intracellular homeostasis both normal and cancer cells. Autophagy has complex and paradoxical dual role in cancers; it can play either tumour suppressor or tumour promoter depending on the tumour type, stage, microenvironment and genetic context. Cancer stem cells (CSCs) cause tumour recurrence and promote resistant to therapy for driving poor clinical consequences. Thus, new healing strategies are urgently needed to annihilate and eradicate CSCs. As chloroquine (CQ) analogues show positive clinical outcome in several clinical trials either standalone or combination with several chemotherapies. Moreover, CQ analogues are known to eliminate CSCs via altering DNA methylation. However, several obstacles such as higher concentrations and dose‐dependent toxicity are noticeable in the treatment of cancers. As tumour cells predominantly rely on mitochondrial actions, mitochondrial targeting FDA‐approved antibiotics are reported to effectively eradicate CSCs alone or combination with chemotherapy. However, antibiotics cause metabolic glycolytic shift in cancer cells for survival and repopulation. This review will provide a sketch of the inhibiting roles of current chloroquine analogues and antibiotic combination in CSC autophagy process and discuss the possibility that pre‐clinical and clinical potential therapeutic strategy for anticancer therapy.
Trends in the effects of pre‐transplant diabetes on mortality and cardiovascular events after kidney transplantation
Authors: Jeon Ja Young , Kim Soo Jung , Ha Kyoung Hwa , Park Ji Hyun , Park Bumhee , Oh Chang‐Kwon , Han Seung Jin 
Published: September 2020

AbstractAims/IntroductionIt is not clear whether survival in kidney transplant recipients with pre‐transplant diabetes has improved over the past decades. We compared the rates of mortality and major adverse cardiovascular events (MACE) after renal transplantation in patients with and without pre‐transplant diabetes. Furthermore, we investigated whether transplant era and recipient age affected the association between diabetes status and adverse events.Materials and MethodsThis retrospective cohort study included 691 patients who underwent renal transplantation between 1994 and 2016 at a single tertiary center. We compared the incidences of post‐transplant mortality and four‐point MACE in patients with and without pre‐transplant diabetes using Kaplan–Meier analysis and the Cox proportional hazard model, and assessed the interactions between diabetes status and transplant era and recipient age.ResultsOf 691 kidney recipients, 143 (20.7%) had pre‐transplant diabetes. The mean follow‐up duration was 94.5 months. Kaplan–Meier analysis showed that patients with pre‐transplant diabetes had higher incidences of post‐transplant mortality and four‐point MACE compared with those without pre‐transplant diabetes (log–rank test, P < 0.001 for both). After adjusting for potential confounding factors, pre‐transplant diabetes was associated with an increased risk of post‐transplant mortality and four‐point MACE (hazard ratio 1.90, 95% confidence interval 1.05–3.44, P = 0.034; and hazard ratio 1.75; 95% confidence interval 1.02–3.00, P = 0.043, respectively). The associations between pre‐transplant diabetes status and all‐cause mortality and four‐point MACE were not affected by transplant era or recipient age.ConclusionsPre‐transplant diabetes remains a significant risk factor for mortality and four‐point MACE in kidney transplant recipients.
Potato creep analysis during storage using experimental measurement and finite element method (FEM)
Authors: Shahgholi Gholamhossein , Latifi Meysam , Jahanbakhshi Ahmad 
Published: September 2020

AbstractAnalysis of static forces has an important role in bulk storage of agricultural products. The forces exerted on individual fruits, vegetables, or grains cause mechanical damage to them and lead to their permanent deformation. By analyzing the forces involved, we can manage them with proper methods and prevent the creation of waste. In this research, by conducting experiments, the required parameters for potato samples were obtained and simulated through the finite element method under load. Creep and tension tests were conducted on a cylindrical potato sample with the diameter and height of 25 mm. Apparent shear modulus had been extracted over time and imported to the Abaqus 2016. Simulation results showed that the maximum tension of 0.061 MPa occurred in layers near the pressure plate. Tension concentration caused the maximum tension of 0.07 MPa in the center of the potato. In accordance with the created tension, maximum displacement of 0.35 mm occurred in contact layer with the pressure plate and by moving away from this plate, displacement decreased linearly and reached to zero at bottom layer. The results showed that measuring the forces in storage and knowing the forces applied to the product can be effective in controlling the storage quality of agricultural products and reducing waste.Practical ApplicationsAnalysis of static forces has important role in bulk storage of agricultural products. By analyzing the involving forces, they can be managed with proper methods and prevent the creation of waste. This paper found that maximum stress and damage occur at force inserted areas and in areas of tubers are in contact with external material like transporting and storage boxes. Then, it should be tried to fabricate new flexible and viscoelastic materials such as polymers which acts like tubers in contact areas to decrease tubers’ stress to minimum value at contact points. Also more attention should be paid to stress concentration that may occur inside tubers which can lead to crush and destroy the product. Stacking more tubers on storage which can increase inserted stress beyond the value that leads to stress concentration should be avoided.
A Systematic Review of Delirium Biomarkers and Their Alignment with the NIA‐AA Research Framework
Authors: Wang Sophia , Lindroth Heidi , Chan Carol , Greene Ryan , Serrano‐Andrews Patricia , Khan Sikandar , Rios Gabriel , Jabbari Shiva , Lim Joanna , Saykin Andrew J. , Khan Babar 
Published: September 2020

OBJECTIVESTo identify whether delirium biomarkers aligned with the National Institute on Aging–Alzheimerʼs Association (NIA‐AA) research framework, a conceptual model that describes the use of diagnostic biomarkers for Alzheimerʼs disease and other related dementias (ADRD).DESIGNSystematic review following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines.SETTINGAcute care and outpatient settings.PARTICIPANTSAdults diagnosed with delirium.METHODS AND MEASUREMENTSMEDLINE, PsycInfo, Embase, and the Cochrane Library were searched for English‐language studies published from January 2010 to February 2020. Studies included adults older than 18 years, identified delirium with a standardized assessment tool, and measured an ADRD biomarker. Independent reviewers determined whether an association between delirium and ADRD biomarker was found, the quality of biomarker data based on the REMARK (REporting recommendations for tumor MARKer prognostic studies) checklist, and the study bias based on the Newcastle‐Ottawa Scale.RESULTSA total of 61,256 citations were identified; 113 studies were included. Most studies did not examine amyloid, tau, or neurodegeneration biomarkers. Delirium may be associated with neurodegeneration biomarkers, but few to no studies found an association with amyloid and tau biomarkers. Delirium was not consistently associated with inflammatory biomarkers. The quality of biomarker data was moderate, and the risk of bias was moderate to high. Studies often did not collect prehospital and posthospital cognitive data.CONCLUSIONMost delirium diagnostic biomarker studies did not measure amyloid, tau, and/or neurodegenerative biomarkers, making characterization of the relationship between delirium and ADRD difficult. Future delirium biomarker diagnostic studies could improve the understanding of pathophysiologic links between delirium with other conditions affecting cognition.
Who has a cushion? The interactive effect of social exclusion and gender on fixed savings
Authors: Yang Lu , Zheng Yuhuang , Chen Rui 
Published: September 2020

AbstractSaving behavior affects both personal welfare and national economies. This study examined the effect of social exclusion, a breakdown of social relationship, on fixed savings, which is especially pertinent to Asians. By considering the cushion hypothesis theory and the gender disparity in social connectedness, this study proposes that men and women display different fixed savings behavior in response to social exclusion. In particular, social exclusion (vs. acceptance) decreases men's fixed savings intention, as isolation stimulates them to expect less social connectedness, which means it is hard to get social support and, thus, heightens their need for resource liquidity. In contrast, social exclusion (vs. acceptance) does not affect women's fixed savings intention because women do not anticipate less social connectedness due to social exclusion. Three experiments provide convergent support for this proposition and verify the theoretical process of the expected social connectedness, coupled with the need for resource liquidity. The alternative explanations for self‐efficacy, power, control, and mood are also discussed.
A contemporary review of Clostridioides difficile infections in patients with haematologic diseases
Authors: Dutta D. , Jafri F. , Stuhr D. , Knoll B. M. , Lim S. H. 
Published: September 2020

AbstractClostridioides (Clostridium) difficile (C. difficile) infection is one of the most common causes of increased morbidity and mortality. Approximately 500 000 C. difficile infections (CDIs) occur each year in the United States, and they result in more than 29 000 deaths. Patients with haematologic diseases are at a higher risk for this infection due to frequent hospitalization and exposure to treatment‐associated risk factors. Whilst several currently available antimicrobial agents offer resolution, recurrence of infection remains a major concern. Recent advancement in deciphering C. difficile virulence mechanisms and identification of its allies in contributing to the infection has led to the development of alternative treatment strategies. Here, we will provide a contemporary discussion of how major risk factors in haematologic diseases, such as immunosuppression, chemoradiation, use of antibiotic, proton pump inhibitor and opioid, and deficiency in butyrate and antimicrobial peptides contribute to C. difficile infection. Next, we will highlight different approaches to control and mitigate this infection such as antibiotic stewardship and faecal microbiota transplantation. Finally, we will explore several emerging treatments such as use of pre‐ and probiotics, immunotherapy and microbiome‐sparing agents.
Antecedents and consequences of workplace mood variability over time: A weekly study over a three‐month period
Authors: Kampf Pia Helen , Hernández Ana , González‐Romá Vicente 
Published: September 2020

This study examines predictors and outcomes of intra‐individual mood variability in the workplace. During a 3‐month weekly study, we collected data on personality (extraversion and neuroticism), positive and negative workplace mood, and job performance from 357 participants. Path analysis revealed a positive relationship between neuroticism and intra‐individual variability in negative mood, which in turn predicted intra‐individual variability in performance. Results contribute to understanding between‐person differences in intra‐individual mood variability, and they suggest expanding the mood – performance relationship from a static perspective to an intra‐individual dispersion perspective. From a practical point of view, our results identify neuroticism as a potential risk factor for unstable performance, but they also give room for fostering predictable performance.Practitioner points

Individuals with higher neuroticism may be prone to fluctuations in negative mood at work and indirectly to inconsistent performance – this highlights the necessity of personality assessment in both personnel selection and development.

Interventions aimed at stabilizing mood can be an effective lever for stabilizing work performance.
Wishart‐gamma random effects models with applications to nonlife insurance
Authors: Denuit Michel , Lu Yang 
Published: September 2020

AbstractRandom effects are particularly useful in insurance studies, to capture residual heterogeneity or to induce cross‐sectional and/or serial dependence, opening hence the door to many applications including experience rating and microreserving. However, their nonobservability often makes existing models computationally cumbersome in a multivariate context. In this paper, it is shown that the multivariate extension to the Gamma distribution based on Wishart distributions for random symmetric positive‐definite matrices (considering diagonal terms) is particularly tractable and convenient to model correlated random effects in multivariate frequency, severity and duration models. Three applications are discussed to demonstrate the versatility of the approach: (a) frequency‐based experience rating with several policies or guarantees per policyholder, (b) experience rating accounting for the correlation between claim frequency and severity components, and (c) joint modeling and forecasting of the time‐to‐payment and amount of payment in microlevel reserving, when both are subject to censoring.
Private protection and public policing
Authors: Hickey Ross , Mongrain Steeve , Roberts Joanne , van Ypersele Tanguy 
Published: September 2020

AbstractThis paper looks at situations in which public and private protection are complementary, that is, when private protection must be coordinated with public protection to be effective. For example, home alarms deter theft by being connected to a local police station: if the police do not respond to a home alarm, the home alarm on its own is virtually useless in halting a crime in action. We make a distinction between gross and net complementarity and substitution, where the latter takes into account the effect on the crime rate. We show that when public and private protection are complements, the optimal provision of public protection trades off the manipulation effect of encouraging private protection with the compensatory effect of providing protection to households that do not privately invest. We discuss the implications of our results for policy and empirical research in this area.
Catechol protects against iron-mediated oxidative brain injury by restoring antioxidative metabolic pathways; and modulation of purinergic and cholinergic enzymes activities
Authors: Salau Veronica F , Erukainure Ochuko L , Koorbanally Neil A , Islam Md Shahidul 
Published: September 2020

Abstract

Objectives
This study was aimed at investigating neuroprotective effect of catechol on redox imbalance, cholinergic dysfunctions, nucleotide hydrolysing enzymes activities, and dysregulated metabolic pathways in iron-mediated oxidative brain injury.

Methods
Oxidative injury was induced in brain tissues by incubating with 0.1 mm FeSO4 and treated with different concentrations of catechol.

Key findings
Catechol significantly elevated glutathione level, superoxide dismutase and catalase activities, while depleting malondialdehyde and nitric oxide levels. It also inhibited the activities of acetylcholinesterase, butyrylcholinesterase, and ATPase, with concomitant elevation of ENTPDase activity. GC-MS analysis revealed that treatment with catechol completely depleted oxidative-generated lipid metabolites. While LC-MS analysis revealed depletion of oxidative-generated metabolites in brain tissues treated with catechol, with concomitant restoration of oxidative-depleted metabolites. Catechol also led to reactivation of oxidative-inactivated taurine and hypotaurine, purine, glutathione, glycerophospholipid, nicotinate and nicotinamide, fructose and mannose, pyrimidine metabolisms and pentose phosphate pathways. Catechol was predicted in silico to be permeable across the blood–brain barrier with a predicted oral LD50 value of 100 mg/kg and a toxicity class of 3.

Conclusion
These results suggest the neuroprotective effects of catechol in iron-mediated oxidative brain injury.