bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attenuation of IL-1ß on the use of glucosamine as an adjuvant in meloxicam treatment in rat models with osteoarthritis
Authors: Khotib Junaidi , Pratiwi Asri Putri , Ardianto Chrismawan , Rahmadi Mahardian 
Published: January 2020

Abstract

Background
Osteoarthritis (OA) is the most prevalent joint disease and a common cause of joint pain, functional loss, and disability. The severity of this disease is always associated with increased levels of proinflammatory cytokines, which play an important role in cartilage damage, synovitis, and other damage to joint tissues. The discovery that many soluble mediators such as cytokines or prostaglandins can increase the production of matrix metalloproteinases by chondrocytes led to the first steps of an inflammatory state. Several studies show that cytokines, such as interleukin 1ß, have a major role in the development of inflammation that occurs in these joints. The use of glucosamine as an adjuvant to meloxicam therapy is expected to inhibit the development of inflammatory OA.

Methods
The OA model in rat was induced by single injection of intraarticular monosodium iodoacetate (MIA). The development of OA was observed for 21 days. Furthermore, the evaluation of glucosamine potency as an adjuvant of meloxicam therapy for reducing IL-1ß was done by combined treatment at a low dose of meloxicam 1 mg/kg BW with glucosamine at a dose of 125, 250, or 500 mg/kg BW orally for 28 days. Response to hyperalgesia and knee joint diameter was measured on days 0, 7, 14, 21, 28, 35, 42, and 49. IL-1ß levels were measured on day 21 and day 49 after MIA injection.

Results
MIA injection successfully induced OA as marked by a significant difference in the time of latency to heat stimulus (p < 0.01) and a significant increase in joint diameter (p < 0.01). On day 21, IL-1ß levels showed a significant decrease in MIA injection (p = 0.05). The administration of meloxicam and glucosamine did not induce significant decrease in knee joint diameter (p > 0.10), but was able to significantly increase the latency time to heat stimulus (p < 0.01). IL-1ß levels also showed a significant decrease after administering a combination of glucosamine and meloxicam (p < 0.01).

Conclusions
Taken together, the use of glucosamine as an adjuvant in meloxicam therapy may be caused by the synergistic mechanism of meloxicam for the attenuation of OA development through systemically reducing IL-1ß.
Intravenous insulin therapy in diabetes mellitus with hyperglycemic crisis and intercurrent illness
Authors: Suprapti Budi , Syarfina Fairuza , Ardianto Chrismawan , Wibisono Cahyo 
Published: January 2020

Abstract

Background
Hyperglycemic crisis is one of the complications of diabetes mellitus, which is common in hospitalized diabetic patient with intercurrent illness, requiring immediate action to control blood glucose. As an effort to attain rapid, gradually and more definite blood glucose, insulin is given intravenously. This study aimed to explore the patterns of blood glucose in hyperglycemic crisis and intercurrent illness, precipitating conditions, insulin regimen and blood glucose (BG) level results.

Methods
It was a cross-sectional study conducted on type 2 diabetic patients. The inclusion criteria were as follows: hospitalized in the general/internal medicine ward with or without any complication or comorbidity receiving intravenous insulin therapy; have pre- and post-BG data after insulin intervention.

Results
In 3 months of the study period, 22 patients fulfilled the inclusion criteria with 28 cases of intravenous insulin therapy, and 1 patient could get more than one intervention. The major condition toward a hyperglycemic crisis condition was infection. The patient’s BG before interventions was 243 mg/dL to more than 600 mg/dL. The dosage of insulin varied from 4 to 10 units per hour, intravenously with a frequency of 1–4 times. The dosage consideration was not only based on BG levels but also on the patient’s condition. The reduction in BG level varied greatly between 0.2 and 28.1 mg/dL per unit of insulin. The BG level of three patients did not decrease. On the other hand, one patient experienced mild hypoglycemia.

Conclusions
Infection conditions were the most common factor for the hyperglycemia crisis. Moreover, intravenous insulin dosing was done individually, and there was a large variation in the results of the decrease in BG levels.
The effect of premixed insulin to blood glucose concentration in patients with type 2 diabetes mellitus
Authors: Puspitasari Arina D. , Kusuma Hayu , Ratri Dinda M.N. , Wibisono Cahyo , Suprapti Budi 
Published: January 2020

Abstract

Background
One of the therapies used to treat type 2 diabetes mellitus (T2DM) disease is combination insulin which consists of rapid-acting insulin and intermediate-acting insulin (premixed). This study aimed to examine the profile of premixed insulin related to blood glucose concentration and to identify the drug interactions due to the combination of premixed insulin with other drugs taken by T2DM patients.

Methods
This study was a prospective observational study with cross-sectional data that were analyzed descriptively. The respondents invited were T2DM patients with or without complication or comorbid disease who received premixed insulin with or without a combination of oral antidiabetic therapy in the Outpatient Unit of Universitas Airlangga Hospital, Surabaya. The research instruments used are data sheet, patient medical record, and fasting and postprandial blood glucose concentration.

Results
A total of 118 patients received premixed insulin therapy, but only 80 patients were included in the inclusion criteria. Based on types of insulin, the combination of 30% aspart and 70% protamine aspart was used by 91.25% T2DM patients, and a combination of 25% insulin lispro and 75% protamine lispro was used by 8.75% T2DM patients. There were 30.3% of patients who could achieve the target of 80–130 mg/dL in fasting blood glucose concentrations, and 35.1% of patients achieved the target of ≤180 mg/dL in postprandial blood glucose concentration. Drug interactions may occur in patients who use premixed insulin with glimepiride, lisinopril, fenofibrate, candesartan, irbesartan, and gemfibrozil.

Conclusions
In this study, premixed insulin have not reached the target of fasting and postprandial blood glucose concentrations in most patients.
Overview of therapeutic changes in antiepileptic drugs in adult patients
Authors: Ratri Dinda M.N. , Rahmadi Mahardian , Islamiyah Wardah R. , Harum Nur Faridah 
Published: January 2020

Abstract

Background
Previous studies suggest a highly variable response of antiepileptic drugs (AEDs). This may be because the response to AEDs has been changed to sustained period of freedom from seizures. This study was conducted to determine whether therapeutic changes of AEDs in the treatment of seizure would be observable in an Indonesian population.

Methods
The study was conducted at the outpatient neurology polyclinic at the Universitas Airlangga Hospital, Surabaya, Indonesia. This was an observational retrospective cohort study, examining the outcomes of 41 cases of switching AEDs (increase or decrease of the dose, switch to branded or generic, or added or reduced type of AEDs).

Results
After treatment with the switched AED, seizure did not show any significant improvement. However, the incidence of seizure during and after the therapeutic change showed a downward trend (from 44% to 32%).

Conclusions
According to the present study, mere optimization of antiepileptic therapy may not result in a steep decrease in seizure events, particularly in polytherapy with AEDs. On the other hand, monotherapy with AEDs evidences to decreasing tendency of seizures.
Ghrelin, obestatin and the ghrelin/obestatin ratio as potential mediators for food intake among obese children: a case control study
Authors: Aly Gamal S. , Hassan Nayera E. , Anwar Ghada M. , Ahmed Hanaa H. , El-Masry Sahar A. , El-Banna Rokia A. , Ahmed Nihad H. , Kamal Ayat N. , Tarkan Reham S. 
Published: January 2020

Abstract

Background
Ghrelin and obestatin are two gastric hormones encoded by the same preproghrelin gene that convey information concerning nutritional status to the central nervous system. Ghrelin has been considered as an appetite stimulating peptide that has a role in the regulation of energy homeostasis. Obestatin has been described for its appetite suppressing effects opposing ghrelin’s effect on food intake. The study aimed to evaluate ghrelin, obestatin and the ghrelin/obestatin ratio in obese children compared to non-obese and correlate them to food macronutrients intake.

Methods
This study is a cross-sectional case control study comprising 60 obese children, in addition to 31 age- and sex-matched controls. All children were subjected to clinical examination, anthropometric assessment, and a 3-day 24-h dietary recall. Fasting serum ghrelin and obestatin levels were evaluated, the ghrelin/obestatin ratio was calculated and they were correlated to macronutrients intake.

Results
Obese children had significantly lower serum fasting levels of ghrelin, obestatin and the ghrelin/obestatin ratio than the control group. The mean intake of total energy and macronutrients was significantly higher in obese children. Ghrelin showed positive correlation with total energy and fat intake in the obese group. Obestatin had positive correlations with total energy and fat intake while the ghrelin/obestatin ratio had a negative correlation with the total energy intake in the control group.

Conclusions
Ghrelin, obestatin and the ghrelin/obestatin ratio were significantly lower in obese children and significantly associated with their total energy intake. Disturbed ghrelin to obestatin balance may have a role in the etiology and pathophysiology of obesity.
The trade-off between the olfactory bulb and eyeball volume in precocious puberty
Authors: Karaoglan Murat , Er Hale Colakoğlu , Aytaç Emel Hatun , Keskin Mehmet 
Published: January 2020

Abstract

Background
The olfactory bulb (OB) and eyeball size change depending on age and puberty. There is a well-established trade-off between sensory structures of the brain such as the eye and the olfactory bulb that depend on environmental circumstances in the evolutionary history of animals.
The aim of this study was to developmentally investigate the potential reciprocal changes between OB and eyeball volumes (EV) in girls with precocious puberty (PP).

Methods
A total of 148 girls aged between 5 and 8 years (63 PP, 85 healthy) were included in the study. Exclusion criteria: Cases of anosmia/hyposmia, neurodegenerative disorder, refractive errors and trauma. The pituitary height (PH), EV and OB volumes were measured on segmentation of a magnetic resonance image (MRI) slice using manual countering. The corrected measurements by body surface were used in all statistical analyses.

Results
In girls with PP, the means of the OB volume and PH were larger (71.11 ± 20.64 mL) and higher (4.62 ± 1.18 mm), respectively, while the mean of EVs was smaller (11.24 ± 2.62 cm3) (p = 0.000). Cut-off values were 62.27 mL, 10.7 cm3 and 4.71 mm for OB volume, EV and PH, respectively. While negative correlations were found between OB volume-EV and EV-PH (r63 = −0.224, p = 0.001 and r63 = −0.116, p = 0.001, respectively), OB volume was positively correlated with PH (r63 = 0.578, p = 0.001).

Conclusions
The present study demonstrates that girls with PP have significantly larger OB volume, but smaller EV, and there is negative correlation between the two structures. These results indicate that there is trade-off between anatomical dimensions of OB and eyeball in favor of OB in PP girls.
Maternal smoking and cannabis use during pregnancy and infant outcomes
Authors: Sturrock Sarah , Williams Emma , Ambulkar Hemant , Dassios Theodore , Greenough Anne 
Published: January 2020

Abstract

Background
Our aim was to determine the prevalence of tobacco smoking and e-cigarettes and cannabis use during pregnancy, whether these were influenced by ethnicity, and their relationship to perinatal outcomes.

Methods
A study was carried out in 4465 infants whose mothers delivered during 2017 and 2018. Self-reported maternal smoking, e-cigarette and cannabis use at booking were recorded. Outcome measures were birthweight and head circumference z-scores and admission to the neonatal intensive care unit (NICU).

Results
Two hundred and five women reported smoking cigarettes (4.7%), five were using e-cigarettes (0.11%) and 106 were using cannabis (2.43%). Women were most likely to smoke if young (15–19 years old) or from a mixed-race or White background. Cigarette smoking was associated with a lower mean z-score for birthweight (−0.587 vs. −0.064) and head circumference (−0.782 vs. −0.157) (both outcomes P < 0.0001). Young, mixed-race women were most likely to be both smoking and using cannabis during pregnancy and their infants had a lower birthweight mean z score (−0.989 vs. −0.587, P = 0.028) and head circumference z score (−1.33 vs. 0.782, P = 0.025) than cigarette use alone.

Conclusion
Young, mixed-race women were most likely to be both smoking and using cannabis during pregnancy and should be targeted for cessation programmes.
Operative vaginal delivery: a review of four national guidelines
Authors: Tsakiridis Ioannis , Giouleka Sonia , Mamopoulos Apostolos , Athanasiadis Apostolos , Daniilidis Angelos , Dagklis Themistoklis 
Published: January 2020

AbstractThere is a broad range in the rates of operative vaginal deliveries (OVD) worldwide, which reflects the variety of local practice patterns, the number of trained clinicians and the lack of international evidence-based guidelines. The aim of this study was to review and compare the recommendations from published guidelines on OVD. Thus, a descriptive review of guidelines from the Royal College of Obstetricians and Gynaecologists (RCOG), the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG), the Society of Obstetricians and Gynaecologists of Canada (SOGC) and the American College of Obstetricians and Gynecologists (ACOG) on instrumental vaginal birth was conducted. All the guidelines point out that the use of any instrument should be based on the clinical circumstances and the experience of the operator. The indications, the contraindications, the prerequisites and the classification for OVD are overall very similar in the reviewed guidelines. Further, they all agree that episiotomy should not be performed routinely. The RCOG, the RANZCOG and the SOGC describe some interventions which may promote spontaneous vaginal birth and therefore reduce the need for OVD. They also highlight the importance of adequate postnatal care and counseling. There is no consensus on the actual technique that should be used, including the type of forceps or vacuum cup, the force and duration of traction or the number of detachments allowed. Hence, there is need for international practice protocols, so as to encourage the clinicians to use OVD when indicated, minimize the complications and reduce rates of cesarean delivery.
Investigating the language-culture nexus in refugee legal advice meetings
Authors: Reynolds Judith 
Published: January 2020

AbstractThis paper explores linguistic and cultural complexity within immigration legal advice communication. Drawing from a linguistic ethnographic study, ethnographic and interactional data from two linked advice meetings about UK refugee family reunion processes are subject to deductive analysis using Risager’s model of the language-culture nexus, within which the intersection of language(s) and culture(s) in a communicative event is conceptualised as a nexus of linguistic, languacultural, discursive, and other (non-linguistic) cultural resources and practices. The paper operationalises this intercultural communication theory in a new and exploratory way to investigate how cultural complexity is manifest, and interactionally managed, at different levels of meaning.The substantive analysis shows how a range of divergent resources, brought in by the different participants, are drawn upon and externalised as communicative practices in both legal advice meetings. Understanding is negotiated interculturally at different levels of meaning – the linguistic, the languacultural, and the discursive – in contrasting ways in each meeting. Methodologically, the paper argues that a strength of Risager’s framework is that it supports a methodical and structured analysis of communicative events characterised by linguistic and cultural complexity, which can be linked to other discourse analytical approaches. The model’s complexity, and its foregrounding of verbal over other semiotic modes, are highlighted as challenges for the analyst.
Interpreting profanity in police interviews
Authors: Hale Sandra , Martschuk Natalie , Goodman-Delahunty Jane , Taibi Mustapha , Xu Han 
Published: January 2020

AbstractProfessional interpreters are obliged by their codes of ethics to interpret the speakers’ speech faithfully, including offensive, profane or vulgar language. In order to achieve this goal, interpreters need to be pragmatically competent, so as to understand the intention and effect of the offensive remark in the source language and be able to appropriately render it into the target language to achieve the same effect in the hearer. Research has shown, however, that not all interpreters abide by this requirement, and many tend to tone down or even omit any offensive language, for a number of reasons, including attempts to protect the hearers or to save their own face. This study examined the ways in which Arabic, Mandarin and Spanish speaking interpreters interpreted offensive language by a suspect in a simulated police interview into English. Experienced qualified interpreters in the three languages, maintained the highest levels of pragmatic equivalence.
Correlation between electrochemical performance degradation and catalyst structural parameters on polymer electrolyte membrane fuel cell
Authors: Li Yunqi , Xiong Danping , Liu Yuwei , Liu Mingtao , Liu Jinzhang , Liang Chen , Li Congxin , Xu Jun 
Published: January 2020

AbstractThe catalysts performance degradation is a crucial issue in decay of the polymer electrolyte membrane fuel cell (PEMFC). The effect of Nafion content, dispersity of Pt nanoparticles and selected types of carbon support on the degradation of electrochemical surface area (ECSA) and double layer capacitance (DLC) were experimentally discussed by accelerated stress test (AST). The catalyst with 20wt% Nafion content exhibited better catalyst performance.i.e., the less DLC and ECSA degradation during AST. Catalysts with well Pt dispersity showed superior %ECSA (the percentage change of ECSA) retention. The heat-treated catalysts exhibited the lowest ECSA and DLC degradation rate due to the larger Pt particle and high carbon corrosion resistance. Moreover, a multi-order model describing the correlation between ECSA and DLC degradation was proposed, providing a vital reference for quantitatively investigating ECSA and DLC degradation in the catalysts with different catalysts structural parameters.
Graphene oxide and zinc oxide decorated chitosan nanocomposite biofilms for packaging applications
Authors: Terzioglu Pınar , Altin Yasin , Kalemtas Ayse , Celik Bedeloglu Ayse 
Published: January 2020

AbstractRecently, due to sustainable development and environmental protection policies, there is increasing interest in the development of new biodegradable polymer-based multifunctional composites. Chitosan is one of the most remarkable and preferred biopolymers, which is environmentally friendly as well as renewable, biocompatible, and inexpensive. Though it has a wide range of potential applications, the major limitation of chitosan – the problem of poor mechanical performance – needs to be solved. In this work, graphene oxide was first produced and then used to manufacture a chitosan/graphene oxide/zinc oxide composite film through a casting method. The properties of the chitosan film and the chitosan/graphene oxide/zinc oxide composite film were investigated using Fourier transform infrared spectroscopy, mechanical, thermal gravimetric, and ultraviolet (UV)-visible spectroscopy analyses. The results showed that the incorporation of graphene oxide and zinc oxide into the chitosan matrix resulted in enhanced mechanical properties and thermal stability of chitosan biocomposite films. The graphene oxide- and zinc oxide-reinforced chitosan film showed 2527 MPa and 55.72 MPa of Young’s modulus and tensile strength, respectively, while neat chitosan showed only 1549 MPa and 37.91 MPa of Young’s modulus and tensile strength, respectively. Conversely, the addition of graphene oxide decreased the transmittance, notably in the UV region.
India: country report on children’s environmental health
Authors: Bangalore Thimmadasiah Narayanaswamy , Joshi Tushar Kant 
Published: January 2020

AbstractChildren contribute substantially to the burden of disease in India. Most common are problems with outdoor and household air pollution, with solutions not immediately apparent or implementable. Children are also often exposed to heavy metals, industrial chemicals and pesticides. Despite advances in some regions, many children still do not have adequate access to clean water and improved sanitation. Infectious diseases remain a problem, especially for children living in poverty. The children of these regions are now facing the dual problems of undernutrition and stunting on the one hand, and overnutrition and obesity on the other.
Construing Scandinavia: A semiotic account of intercultural exchange in theme park design
Authors: Sandin Gunnar 
Published: January 2020

AbstractEvaluation of other cultures is a strong force in a culture’s definition of itself. Cultures are formed in encounters that include domination, conflict, and dismissal as much as appreciation and smooth exchange. In this paper, the construction of cultural identity is discussed, with reference to a Scandinavian Theme Park proposal made in cooperation between American design consultants and a local Swedish team of planners and visionaries. The image production in this design proposal, which never came to be realised in architectural production, shows that “Scandinavia” appears as a two-some dialogic construction that adopts stereotyped cultural identities, and that it was not brought to any wider public dialogue. In a semiotic account of this architectural decision-making, models of culture (Lotman. 1990.Universe of the mind: A semiotic theory of culture. London: Tauris.) are discussed in terms of the tripartition of culture into Ego-culture, Alter-culture and Alius-culture (Sonesson. 2000. Ego meets alter: The meaning of otherness in cultural semiotics.Semiotica128(3/4). 537–559.; Cabak Rédei, Anna. 2007.An inquiry into cultural semiotics: Germaine de Staël’s autobiographical travel accounts. Lund: Lund University Press.), considered as a basic abstracted backdrop of what is meant by cultural difference. In this paper it is suggested that this tripartite view on culture, can be further discussed in reflection of post-colonial studies, notably through terms such as “mimicry” (Bhabha. 1984. Of mimicry and man: The ambivalence of colonial discourse.October28. 125–133.) and “subalterity” (Spivak. 1988. Can the subaltern speak?. In Cary Nelson & Lawrence Grossberg (eds.),Marxism and the interpretation of culture, 271–313. Urbana & Chicago: University of Illinois Press.). The model of culture can furthermore be discussed through Peirce’s distinction between different stages and carriers of representation, adding to the cultural model an understanding of what it means, over time, for a culture to relate to an admired as well as to a neglected other cultural actor.