bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Sticking to One's Post” or “Backing the Right Captain”?—The Impact of Corporate Environmental, Social, and Governance Performance on Employee Turnover
Authors: Zhou Shengshi 
Published: December 2024

ABSTRACTDo employees respond to a firm's environmental, social, and governance (ESG) performance? This study examines the relationship between corporate ESG performance and employee turnover, employing social identity theory and rational action theory. Using data from Chinese A‐share nonfinancial listed firms over the period from 2011 to 2020, the results reveal a positive U‐shaped relationship. Specifically, moderate levels of ESG performance are associated with reduced employee turnover. And this relationship is more pronounced in the environmental and social pillars. Further analysis shows that employees at high‐performing firms are more concerned with ESG performance, and those with high environmental awareness exhibit greater sensitivity to it. Information asymmetry may mediate the relationship between corporate ESG performance and employee turnover. These results contribute valuable insights into the broader implications of ESG performance for employee turnover, clarify the underlying mechanisms, and offer practical guidance for refining corporate ESG strategies.
Unveiling New Clinical and Genetic Insights in Ultra‐Rare Intellectual Disability Phenotypes: A Study of a Turkish Cohort
Authors: Turkyilmaz Ayberk , Sager Safiye Gunes , Terali Kerem , Kart Pinar Ozkan , Kamasak Tulay , Ayaz Akif , Cebi Alper Han , Cansu Ali 
Published: December 2024

ABSTRACTIntellectual disability (ID) is defined as a severe impairment in reasoning, learning, and problem‐solving abilities along with adaptive behavior that occurs before the age of 18 years. The present study aimed to present the clinical and genetic data of a cohort of Turkish pediatric patients diagnosed with the ultrarare (which only up to 20 cases having been reported in the relevant literature thus far) ID phenotype. A total of 29 patients from 26 different families, who were diagnosed with ultrarare ID upon whole exome sequencing (WES) analysis, were included in the study. Of the patients included in the study, 18 (62%) were male and 11 (38%) were female. There was consanguinity between parents in 16 families (55%). With respect to the ID phenotype, three families had cases with a similar phenotype, while 23 families (88%) had sporadic cases. Upon molecular analysis, 28 different variations in 23 different genes were noted. Of the variations detected, 15 were missense, 6 nonsense, 4 frameshift, 2 splice‐site, and 1 gross exonic deletion. Nine (32%) variations were novel among the detected variations. This study summarized the clinical and genetic features of 23 different ultrarare ID phenotypes by means of WES study, including copy number variations (CNVs) analysis. Novel clinical and genetic findings in the present study contribute to a better understanding of the genotypic and phenotypic spectrum. The effects of some rare variations on protein structure were revealed by means of in silico modeling. Newly described cases with ultrarare phenotypes help achieve a clearer description of the clinical and genetic manifestations of the syndromes and gain a better understanding of the molecular mechanisms.
Severe Allergic Contact Dermatitis From Octylisothiazolinone in Over‐Ear Headphones: A Case Series
Authors: Menanteau Marion , Fenech Goël , Adam Benjamin , Langlois Eddy , Marcant Pierre , Pelletier Eric , Staumont‐Sallé Delphine , Bensefa‐Colas Lynda , Crepy Marie‐Noëlle 
Published: December 2024

ABSTRACTBackgroundOctylisothiazolinone (OIT; CAS 26530–20‐1) is used as a biocide in leather products.ObjectivesTo report several cases of allergic contact dermatitis (ACD) from the use of headphones containing OIT, and to highlight the strong allergic potential of this preservative.Patients and MethodsFour patients with ACD from headphones were patched tested using the European baseline, cosmetic, rubber, plastics/glues and acrylates series. Patients were also tested to different parts of their own headphones (‘as is’). Chemical analyses of the headphones was additionally performed with Ultra Performance Liquid Chromatography—tandem mass spectrometry (UPLC‐MS/MS).ResultsAll patients had developed localised ACD to the contact sites of the headphones, except for one patient who developed ‘angioedema‐like’ dermatitis. All patients were shown to have been primarily sensitised to OIT. UPLC‐MS/MS analysis confirmed OIT in the leather ear pads of the headphones.ConclusionsOIT is a relevant and strong sensitizer in leather, and may cause severe ACD. Safer use concentrations (limits) of OIT, as well as product labelling in the leather industry, may be required to ensure a better protection of consumers.
Hepatic thyroid hormone receptor‐β signalling: Mechanisms and recent advancements in the treatment of metabolic dysfunction‐associated steatohepatitis
Authors: Polyzos Stergios A. , Targher Giovanni 
Published: December 2024

AbstractThe pharmacotherapy of metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive form, the metabolic dysfunction‐associated steatohepatitis (MASH), remains a hot topic in research and a largely unmet need in clinical practice. As the first approval of a disease‐specific drug, resmetirom, was regarded as a milestone for the management of this common liver disease, this comprehensive and updated review aimed to highlight the importance of the hepatic thyroid hormone (TH) receptor (THR)‐β signalling for the treatment of MASH, with a special focus on resmetirom. First, the genomic and non‐genomic actions of the liver‐directed THR‐β mediated mechanisms are summarized. THR‐β has a key role in hepatic lipid and carbohydrate metabolism; disruption of THR‐β signalling leads to dysmetabolism, thus promoting MASLD and possibly its progression to MASH and cirrhosis. In the clinical setting, this is translated into a significant association between primary hypothyroidism and MASLD, as confirmed by recent meta‐analyses. An association between MASLD and subclinical intrahepatic hypothyroidism (i.e. a state of relatively low hepatic triiodothyronine concentrations, with circulating TH concentrations within the normal range) is also emerging and under investigation. In line with this, the favourable results of the phase 3 placebo‐controlled MAESTRO trials led to the recent conditional approval of resmetirom by the US FDA for treating adults with MASH and moderate‐to‐advanced fibrosis. This conditional approval of resmetirom opened a new window to the management of this common and burdensome liver disease, thus bringing the global scientific community in front of new perspectives and challenges.
Why do governments fund some humanitarian appeals but not others?
Authors: Rost Nicolas , Clarke John N. 
Published: December 2024

AbstractMotivationWhat explains the fact that the humanitarian response in some crises is well funded, while other humanitarian emergencies are largely neglected? The literature identifies three groups of factors that influence aid allocations: needs in recipient countries, donor countries' interests, and agenda setting driven by media coverage; although there is debate over how relatively important these are.PurposeThis study tests existing theory by adding three novel aspects.Approach and MethodsFirst, rather than just measuring the amount of money available, we consider the share of funding that is provided against the stated requirements. Second, we measure humanitarian needs in a more detailed way than has typically been the case. Third, we use datasets that have been underutilized in the academic literature.FindingsBy using these three novel approaches, we confirm that all three factors—humanitarian needs, strategic interests, agenda setting—play a role. However, the most consistent factor is media coverage. We are also able to distinguish between different dimensions of need: the number of hosted refugees makes a difference, but the number of displaced people does not. We find that countries with the worst human rights situations attract lower funding levels and more democratic countries attract more funding.Policy ImplicationsDonors should consider how the factors identified in this study influence their funding decisions in the aggregate. They should be aware of how media coverage may influence their allocations of humanitarian funding. Journalists should be aware of potential biases in their reporting on humanitarian emergencies. Aid agencies should consider counteracting the factors that are associated with underfunded emergencies.
Dimensions of Parental Involvement in Refugee and Migrant Students' Education: Views of Parents and Teachers of Zones of Educational Priority (ZEP) Classes of a Greek Intercultural High School
Authors: Karpontini Margarita 
Published: December 2024

ABSTRACTParental involvement and its various aspects regarding students' education have drawn scholarly attention over the last few decades. Parents from minoritised backgrounds lack opportunities for active participation in their children's education, which, in turn, could prove fruitful for children's academic progress and future social inclusion. The present case study approaches views on parental involvement in Zones of Educational Priority (ZEP) classes, as displayed by Greek language teachers, as well as by a sample of ZEP students' parents, stemming from refugee and migrant backgrounds. It specifically addresses experiences discussed by both parents and teachers in the process of communication across settings, the emerging patterns from both sides, and the strategies considered as most effective for home–school communication by the participants. The current study corroborates previous research on the importance of parental involvement in refugee and migrant education and further advances it through participants' perspectives on solutions. It constitutes an effort to encourage more extensive research and potentially impact the design of educational policies and practices on parental involvement regarding ZEP classes.
Plasma microRNAs as prognostic biomarkers for development of severe epilepsy after experimental traumatic brain injury—EpiBioS4Rx Project 1 study
Authors: Heiskanen Mette , Ndode‐Ekane Xavier Ekolle , Ali Idrish , Santana‐Gomez Cesar , Puhakka Noora , Gupta Shalini Das , Andrade Pedro , Immonen Riikka , Casillas‐Espinosa Pablo , Manninen Eppu , Smith Gregory , Brady Rhys D. , Silva Juliana , Braine Emma , Hudson Matt , Yamakawa Glen R. , Jones Nigel C. , Shultz Sandy R. , Harris Neil G. , Wright David K. , Gröhn Olli , Staba Richard J. , O'Brien Terence J. , Pitkänen Asla 
Published: December 2024

AbstractObjectiveTo test a hypothesis that acutely regulated plasma microRNAs (miRNAs) can serve as prognostic biomarkers for the development of post‐traumatic epilepsy (PTE).MethodsAdult male Sprague–Dawley rats (n = 245) were randomized to lateral fluid‐percussion–induced traumatic brain injury (TBI) or sham operation at three study sites (Finland, Australia, United States). Video‐electroencephalography (vEEG) was performed on the seventh post‐injury month to detect spontaneous seizures. Tail vein plasma collected 48 h after TBI for miRNA analysis was available from 209 vEEG monitored animals (45 sham, 164 TBI [32 with epilepsy]). Based on small RNA sequencing and previous data, the seven most promising brain enriched miRNAs (miR‐183‐5p, miR‐323‐3p, miR‐434‐3p, miR‐9a‐3p, miR‐124‐3p, miR‐132‐3p, and miR‐212‐3p) were validated by droplet digital polymerase chain reaction (ddPCR).ResultsAll seven plasma miRNAs differentiated between TBI and sham‐operated rats. None of the seven miRNAs differentiated TBI rats that did and did not develop epilepsy (p > .05), or rats with ≥3 vs <3 seizures in a month (p > .05). However, miR‐212‐3p differentiated rats that developed epilepsy with seizure clusters (i.e., ≥3 seizures within 24 h) from those without seizure clusters (.34 ± .14 vs .60 ± .34, adj. p < .05) with an area under the curve (AUC) of .81 (95% confidence interval [CI] .65–.97, p < .01, 64% sensitivity, 95% specificity). Lack of elevation in miR‐212‐3p also differentiated rats that developed epilepsy with seizure clusters from all other TBI rats (n = 146, .34 ± .14 vs .55 ± .31, p < .01) with an AUC of .74 (95% CI .61–.87, p < .01, 82% sensitivity, 62% specificity). Glmnet analysis identified a combination of miR‐212‐3p and miR‐132‐3p as an optimal set to differentiate TBI rats with vs without seizure clusters (cross‐validated AUC .75, 95% CI .47–.92, p < .05).SignificancemiR‐212‐3p alone or in combination with miR‐132‐3p shows promise as a translational prognostic biomarker for the development of severe PTE with seizure clusters.
Evaluation of the Flats Fishery to Formulate and Propose a Regional Strategic Plan to Improve Fisheries and Protected‐Area Conservation and Management in the Yucatan Peninsula of Belize and Mexico
Authors: Perez Addiel U. , Adams Aaron 
Published: December 2024

ABSTRACTCoastal fishery resources shared by Belize and Mexico emphasize the need for bi‐national conservation and management strategies. We used the recreational flats fishery as a model to: (1) evaluate the strengths and weaknesses of a mixed‐methods approach for fishery conservation and management and (2) propose a general strategic plan to guide conservation and management that also benefits biodiversity of aquatic resources. The approach consisted of gathering local knowledge, observing participants, reviewing literature, and interviewing key representatives of the flats fishing community, resource managers (governmental and co‐managers), academia and non‐governmental organizations, followed by online surveys, to rank overall findings and prioritize concerns identified by a Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis. Our findings indicated that science, education, conservation, and management were important. The strategic framework included goals, objectives, strategies, and outcomes that will depend on validation and collaboration amongst sectors to generate information and application to fisheries and protected areas (PAs) management to benefit local communities, national economies, and preservation of biodiversity. Prioritized needs included: (1) science to address habitat loss and degradation, overharvest, habitat use conflict resolution, fishing pressure, and protection of key habitats for all life cycles of target species; (2) education and awareness to increase knowledge, address fish handling practices, and guide conservation and management decision‐making; (3) inclusion of the flats fishery in conservation plans, PAs, development, and economic plans; and (4) improved enforcement of regulations to ensure sustainability.
Effects of Hyporheic Water Exchange on Microbial Community Structure and Function: A Case Study in the Beiluo River, Loess Plateau, China
Authors: Tang Bin , Song Jinxi , Zhang Junlong , Rehman Adnanul , Li Bingjie , Long Yongqing , Li Nan , Mao Ruichen , Feng Jiayuan , Chen Junhang , Zhou Shengsheng , Qu Yue 
Published: December 2024

ABSTRACT

Microbial communities in riverine hyporheic zones provide essential ecosystem services. However, the mechanisms whereby they respond to hyporheic water exchange under different habitat stress conditions remain poorly understood. Therefore, investigating the impact of riverine hyporheic exchange on the microbial community composition and its potential ecological function is essential, particularly in the seasonal rivers of northern China.

To elucidate the structure and function of hyporheic zone sediment microbial communities in response hyporheic exchange and environmental fluctuations, we examined associations by performing in situ falling‐head permeameter tests and eDNA techniques.

The primary findings were as follows: (1) We detected variations in the spatial distribution patterns of streambed hydraulic conductivity (range, 0.055–3.490 m/day) and vertical fluxes (range, 1.886–342.0 mm/day) among different monitoring stations. (2) Microbial communities displayed compositional similarities and spatial heterogeneity. Stations with limited vertical exchange were characterised by reduced species diversity. (3) Prokaryotes showed better modularity characteristics with higher stability and functional diversity than eukaryotic communities. (4) Differences in the abundance of microbial metabolism and genetic functions were observed among different habitats.

This study emphasises the significance of local hydrological patterns (such as downwelling) in maintaining riverine environmental elements and acting as hotspots for microbial diversity within the hyporheic zone. The heterogeneity of the hydrological patterns governing hyporheic water exchange can explain the abundance, species diversity and biogeochemical processes of microorganisms within this zone.
Performance of urine Xpert MTB/RIF ultra in a tuberculosis screening strategy in hospitalized patients with advanced HIV disease: Results from an implementation initiative in Brazil
Authors: Falci Diego R. , Pasqualotto Alessandro C. , Vieceli Tarsila , Sued Omar , Reis Nicole , Soares Renata B. A. , Godoy Cassia S. M. , Hatem Nayla A. , dos Santos Nathalia Pereira , Regis Razzolini Bruna , Sprinz Eduardo , Perez Freddy 
Published: December 2024

AbstractObjectivesTo evaluate the performance of Xpert MTB/RIF Ultra testing in urine samples as part of a TB screening strategy in patients with advanced HIV disease (AHD).MethodsWe conducted a multicentre prospective cohort study across three HIV reference hospitals in Brazil, between January and December 2023. The study included adult hospitalized patients with AHD, defined by a CD4 count of <200 cells/μL in the last 3 months or clinical presentation suggestive of opportunistic infection, without effective antiretroviral treatment. Participants underwent systematic tuberculosis (TB) screening using urine Xpert MTB/RIF Ultra and TB lipoarabinomannan (TB‐LAM) tests. The diagnosis performance of urine Xpert MTB/RIF Ultra was assessed including sensitivity, specificity, and positive and negative predictive values. Disease characterization was based on the Global Tuberculosis Dictionary. Survival at 30 and 90 days was also evaluated.ResultsUrine molecular testing was performed on 133 patients. Xpert MTB/RIF Ultra showed a sensitivity of 20.7% in bacteriologically confirmed TB cases and 21.2% in cases that included both clinically diagnosed and bacteriologically confirmed TB. The addition of urine Xpert MTB/RIF Ultra to TB‐LAM led to the detection of three additional cases, representing a 6.3% increase from the 48 cases detected by TB‐LAM. Xpert MTB/RIF Ultra had a specificity of 96.9% and no rifampicine resistance mutations were detected. Overall mortality was 16/133 (12.0%) at 30 days and 25/127 (19.7%) at 90 days.ConclusionsThere was a high overlap between urine TB‐LAM and Xpert MTB/RIF Ultra results, with the addition of Xpert MTB/RIF providing limited additional benefit for TB screening in patients with AHD.
Are Estonians the true Finns? Homeland and residence country perspectives on support for the populist radical right
Authors: Jakobson Mari‐Liis , Sipinen Josefina , Taimla Kaarel 
Published: December 2024

AbstractThis article tackles the puzzle of why immigrant voters would support a populist radical right party (PRRP). Exploring the case of Estonian residents in Finland, it draws on 13 in‐depth interviews conducted with Estonians who voted for the Finns Party in the 2021 Finnish local elections, and survey data. The article produces a conceptual model explaining how both homeland politics and integration to residence country contribute to PRRP support. Estonians' support for the Finns Party partly results from a political realignment in Estonia and the Estonian PRRP's campaign activities. The influence of homeland politics is also furthered by their lack of political integration in the residence country, and their experience of immigrant integration, which prompts them to identify as ‘the good immigrant’ as opposed to groups they consider less integrated and thus position as inferior to themselves.
Dynamic open time‐dependent traveling salesman problem with speed optimization
Authors: Çimen Mustafa , Soysal Mehmet , Belbağ Sedat , Kazanç Hande Cansın 
Published: December 2024

AbstractIncreased awareness of people of the problems caused by CO2 emissions brings companies to consider environmental issues in their distribution systems. The rapid advance in technology allows logistics companies to tackle with dynamic nature of distribution networks (e.g., a change in the vehicle speed due to unexpected events). The planned routes at the beginning of the time horizon could be subject to modification at any point in time to account for the recent traffic information. This study addresses a dynamic open time‐dependent traveling salesman problem. The problem also involves speed optimization that aims to find optimal vehicle speed in a dynamic setting by respecting real‐time traffic conditions. We develop a mixed integer linear programming (MILP) formulation for the addressed problem to determine routing and vehicle speed decisions. Furthermore, a MILP‐based myopic‐clustering decomposition heuristic algorithm has been introduced to solve large‐sized instances within reasonable solution times. The use of the heuristic algorithm provides decision‐makers with a responsiveness capacity by enabling fast incorporation of dynamically observed data during operations. The numerical analyses demonstrate the potential benefits of employing the proposed tools.
Two new species of Mylochromis (Cichlidae) from Lake Malawi, Africa
Authors: Turner George F. 
Published: December 2024

AbstractTwo new species of Mylochromis Regan 1920 are described from specimens collected on shallow rocky habitats on the northwestern coast of Lake Malawi. The generic designation is based on their prominent oblique‐striped pattern and lack of any of the unique features of other Malawi cichlid genera with this pattern. Mylochromis rotundus sp. nov. is distinguished from most congeneric species by its relatively deep, rounded body and lack of enlarged pharyngeal teeth. It is further distinguished from Mylochromis semipalatus and Mylochromis melanonotus (if they are different species) by its relatively shorter snout. Mylochromis durophagus sp. nov. is distinguished from most congeneric species by its strongly molarized pharyngeal dentition. It differs from Mylochromis mola by having a shorter snout, a less acutely pointed head profile, a deeper body, and a more continuous oblique stripe. M. durophagus has a much less steep head profile than Mylochromis anaphyrmus or Mylochromis sphaerodon. It is suggested that M. rotundus was previously identified informally as Mylochromis sp. “mollis north,” and M. durophagus as Mylochromis sp. “mollis chitande.” Lectotypes are designated for comparator species M. sphaerodon and Mylochromis subocularis.