bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rebleeding and bleeding in the year following intracranial aneurysm coiling: analysis of a large prospective multicenter cohort of 1140 patients—Analysis of Recanalization after Endovascular Treatment of Intracranial Aneurysm (ARETA) Study
Authors: Pierot Laurent , Barbe Coralie , Herbreteau Denis , Gauvrit Jean-Yves , Januel Anne-Christine , Bala Fouzi , Ricolfi Frédéric , Desal Hubert , Velasco Stéphane , Aggour Mohamed , Chabert Emmanuel , Sedat Jacques , Trystram Denis , Marnat Gaultier , Gallas Sophie , Rodesch Georges , Clarençon Frédéric , Papagiannaki Chrysanthi , White Phil , Spelle Laurent 
Published: June 2020

BackgroundEndovascular treatment is the first line therapy for the management of ruptured and unruptured intracranial aneurysms, but delayed aneurysm rupture leading to bleeding/rebleeding can occur subsequently. ARETA (Analysis of Recanalization after Endovascular Treatment of intracranial Aneurysm) is a prospective, multicenter study conducted to analyze aneurysm recanalization. We analyzed delayed bleeding and rebleeding in this large cohort.Methods16 neurointerventional departments prospectively enrolled patients treated for ruptured and unruptured aneurysms between December 2013 and May 2015 (ClinicalTrials.gov:NCT01942512). Participant demographics, aneurysm characteristics and endovascular techniques were recorded. Data were analyzed from participants with ruptured or unruptured aneurysms treated by coiling or balloon-assisted coiling. Rates of bleeding and rebleeding were analyzed and associated factors were studied using univariable and multivariable analyses.ResultsThe bleeding rate was 0.0% in patients with unruptured aneurysms and 1.0% (95% CI 0.3% to 1.7%) in patients with ruptured aneurysms. In multivariate analysis, two factors were associated with rebleeding occurrence: incomplete aneurysm occlusion after initial treatment (2.0% in incomplete aneurysm occlusion vs 0.2% in complete aneurysm occlusion, OR 10.2, 95% CI 1.2 to 83.3; p=0.03) and dome-to-neck ratio (1.5±0.5 with rebleeding vs 2.2±0.9 without rebleeding, OR 0.2, 95% CI 0.04 to 0.8; p=0.03). Modalities of management of aneurysm rebleeding as well as clinical outcomes are described.ConclusionsAneurysm coiling affords good protection against bleeding (for unruptured aneurysms) and rebleeding (for ruptured aneurysms) at 1 year with rates of 0.0% and 1.0%, respectively. Aneurysm occlusion and dome-to-neck ratio are the two factors that appear to play a role in the occurrence of rebleeding.
Left distal radial access in patients with arteria lusoria: insights for cerebral angiography and interventions
Authors: Majmundar Neil , Patel Pratit , Gadhiya Arjun , Patel Nitesh Vijay , Gupta Gaurav , Agarwalla Pankaj K , Khandelwal Priyank 
Published: June 2020

BackgroundThe transradial approach (TRA) is frequently used for neurointerventional procedures as it is safer, improves patient comfort, and decreases costs and procedural time in comparison with the transfemoral approach (TFA). Patients with arteria lusoria, or an aberrant right subclavian artery (ARSA), provide a unique challenge for cerebral angiography and interventions when using the TRA.ObjectiveTo examine the hypothesis that the extreme angulation encountered while accessing the great vessels from the right TRA could be overcome by reversing the approach to the left distal TRA (dTRA).MethodsA prospectively maintained database of transradial neurointerventional cases since 2018 was searched. Six cases from 850 were identified, in which the left dTRA was used. Three cases were for patients with an ARSA. For the three cases of interest, patient history, pathology, imaging, and access techniques were reviewed.ResultsTwo diagnostic cerebral angiography cases and one intervention were successfully performed through a left dTRA.ConclusionsProper positioning of the left wrist and familiarity with forming the Simmons catheter can overcome this anatomical challenge. This technique and results further demonstrate that the left distal radial artery is a feasible access site for catheterization of bilateral carotid, left vertebral, and right subclavian arteries for patients with an ARSA.
Deep venous communication in vein of Galen malformations: incidence, Imaging, and Implications for treatment
Authors: Kortman Hans , Navaei Ershad , Raybaud Charles A , Bhatia Kartik Dev , Shroff Manohar , terBrugge Karel , Armstrong Derek , Pereira Vitor M , Dirks Peter B , Krings Timo , Muthusami Prakash 
Published: June 2020

BackgroundFailure to appreciate deep venous drainage pathways is a major cause of severe complications in the endovascular treatment of vein of Galen aneurysmal malformations (VOGMs).ObjectiveTo report deep venous drainage patterns in patients with VOGM, emphasizing the internal cerebral veins, and to describe the challenges in evaluating these.MethodsPatients with VOGM presenting to our institute between 2000 and 2018 were retrospectively analyzed. Patients with complete and good quality imaging datasets were included in the study. Three neuroradiologists with expertise in the subject independently analyzed the deep venous drainage patterns on multi-sequence MRI and digital subtraction angiography. Follow-up imaging studies were analyzed for alterations in deep venous drainage patterns that occurred following endovascular treatment. Descriptive statistics were used to report findings.ResultsTwenty-three patients had optimal quality MRI imaging and 25 had optimal quality DSA imaging available. In 14/23 (61%) patients, internal cerebral vein (ICV) communication could be reliably identified on MRI and in 8/25 (32%) patients on DSA. Deep venous communication with the VOGM was demonstrated in 8/26 (30.8%) patients. One (3.8%) patient demonstrated ICV communication with the VOGM only on postoperative imaging, while in 2 (8%) patients the ICV drainage route changed from VOGM to alternative pathways after the procedure. Other variant pathways included lateral mesencephalic vein, superior or inferior sagittal sinus, anterior mesencephalic vein, tentorial sinus, deep Sylvian vein, and superior vermian vein.ConclusionICV communication with the VOGM is not uncommon and requires dedicated preprocedural imaging to identify it. However, there are significant challenges in assessing this communication in the presence of high-flow fistulae, vessel tortuosity and size, and contrast limitations in this population.
A formalism for magnon gravitational wave detectors
Authors: Ito Asuka , Soda Jiro 
Published: June 2020

AbstractIn order to detect high frequency gravitational waves, we need a new detection method. In this paper, we develop a formalism for a gravitational wave detector using magnons in a cavity. Using Fermi normal coordinates and taking the non-relativistic limit, we obtain a Hamiltonian for magnons in gravitational wave backgrounds. Given the Hamiltonian, we show how to use the magnons for detecting high frequency gravitational waves. Furthermore, as a demonstration of the magnon gravitational wave detector, we give upper limits on GHz gravitational waves by utilizing known results of magnon experiments for an axion dark matter search.
An electrohydrodynamic (EHD) printing method with nanosilver ink for flexible electronics
Authors: Zhang Xinyu , Chi Xiang , Li Zongan , Yuan Zhe , Yang Jiquan , Zhu Liya , Zhang Feng 
Published: June 2020

In this paper, the electrohydrodynamic (EHD) printing method for the flexible electronics with nanosilver ink was studied. The effect of DC voltage and air pressure on the printed nanosilver line was experimentally researched on the printing system. The necessary working voltage was above 600 V DC voltage, and when the voltage reached 1100 V, the line width increased from [Formula: see text] to [Formula: see text]. The air supply of [Formula: see text] resulted an obviously larger width than that of [Formula: see text], but the printing process was unstable on the [Formula: see text] condition. The EHD printing was applied to realize nanosilver ink line ranged from [Formula: see text] to [Formula: see text] and a kind of antenna pattern for radio frequency identification devices (RFID) was fabricated. This kind of EHD printing method has the advantages of high flexibility and printing resolution and shows potential prospects in the field of flexible electronics.
Chapter 2 Geodynamics of the SW Pacific: a brief review and relations with New Caledonian geology
Authors: Collot J. , Patriat M. , Sutherland R. , Williams S. , Cluzel D. , Seton M. , Pelletier B. , Roest W. R. , Etienne S. , Bordenave A. , Maurizot P. 
Published: June 2020

Abstract
The SW Pacific region consists of a succession of ridges and basins that were created by the fragmentation of Gondwana and the evolution of subduction zones since Mesozoic times. This complex geodynamic evolution shaped the geology of New Caledonia, which lies in the northern part of the Zealandia continent. Alternative tectonic models have been postulated. Most models agree that New Caledonia was situated on an active plate margin of eastern Gondwana during the Mesozoic. Extension affected the region from the Late Cretaceous to the Paleocene and models for this period vary in the location and nature of the plate boundary between the Pacific and Australian plates. Eocene regional tectonic contraction included the obduction of a mantle-derived Peridotite Nappe in New Caledonia. In one class of model, this contractional phase was controlled by an east-dipping subduction zone into which the Norfolk Ridge jammed, whereas and in a second class of model this phase corresponds to the initiation of the west-dipping Tonga–Kermadec subduction zone. Neogene tectonics of the region near New Caledonia was dominated by the eastwards retreat of Tonga–Kermadec subduction, leading to the opening of a back-arc basin east of New Caledonia, and the initiation and southwestwards advance of the New Hebrides–Vanuatu subduction zone towards New Caledonia.
Elementary Students’ Understanding of CS Terms
Authors: Vandenberg Jessica , Tsan Jennifer , Boulden Danielle , Zakaria Zarifa , Lynch Collin , Boyer Kristy Elizabeth , Wiebe Eric 
Published: June 2020

The language and concepts used by curriculum designers are not always interpreted by children as designers intended. This can be problematic when researchers use self-reported survey instruments in concert with curricula, which often rely on the implicit belief that students’ understanding aligns with their own. We report on our refinement of a validated survey to measure upper elementary students’ attitudes and perspectives about computer science (CS), using an iterative, design-based research approach informed by educational and psychological cognitive interview processes. We interviewed six groups of students over three iterations of the instrument on their understanding of CS concepts and attitudes toward coding. Our findings indicated that students could not explain the terms
computer programs
nor
computer science
as expected. Furthermore, they struggled to understand how coding may support their learning in other domains. These results may guide the development of appropriate CS-related survey instruments and curricular materials for K–6 students.
Oxygen-Enhanced Optoacoustic Tomography Reveals the Effectiveness of Targeting Heme and Oxidative Phosphorylation at Normalizing Tumor Vascular Oxygenation
Authors: Ghosh Poorva , Guo Yihang , Ashrafi Adnin , Chen Jingyu , Dey Sanchareeka , Zhong Shigen , Liu Jie , Campbell James , Konduri Purna Chaitanya , Gerberich Jeni , Garrossian Massoud , Mason Ralph P. , Zhang Li , Liu Li 
Published: June 2020

Abstract

Multispectral optoacoustic tomography (MSOT) is an emerging noninvasive imaging modality that can detect real-time dynamic information about the tumor microenvironment in humans and animals. Oxygen enhanced (OE)-MSOT can monitor tumor vasculature and oxygenation during disease development or therapy. Here, we used MSOT and OE-MSOT to examine in mice the response of human non–small cell lung cancer (NSCLC) xenografts to a new class of antitumor drugs, heme-targeting agents heme-sequestering peptide 2 (HSP2) and cyclopamine tartrate (CycT). HSP2 inhibits heme uptake, while CycT inhibits heme synthesis in NSCLC cells, where heme is essential for ATP generation via oxidative phosphorylation. HSP2 and CycT can inhibit ATP generation and thereby suppress NSCLC cell tumorigenic functions. MSOT showed that treatment of NSCLC tumors with HSP2 or CycT reduced total hemoglobin, increased oxygen saturation, and enhanced the amplitude of response to oxygen gas breathing challenge. HSP2 and CycT normalized tumor vasculature and improved tumor oxygenation, where levels of several hypoxia markers in NSCLC tumors were reduced by treatment with HSP2 or CycT. Furthermore, treatment with HSP2 or CycT reduced levels of angiogenic factor VEGFA, its receptor VEGFR1, and vascular marker CD34. Together, our data show that heme-targeting drugs HSP2 and CycT elicit multiple tumor-suppressing functions, such as inhibiting angiogenic function, normalizing tumor vasculature, alleviating tumor hypoxia, and inhibiting oxygen consumption and ATP generation.

Significance:
Heme-targeting agents HSP2 and CycT effectively normalize tumor vasculature and alleviate tumor hypoxia, raising the possibility of their combination with chemo-, radio-, and immunotherapies to improve antitumor efficacy.
See related commentary by Tomaszewski, p. 3461
Functional Categorization of BRCA1 Variants of Uncertain Clinical Significance in Homologous Recombination Repair Complementation Assays
Authors: Bouwman Peter , van der Heijden Ingrid , van der Gulden Hanneke , de Bruijn Roebi , Braspenning Merel E. , Moghadasi Setareh , Wessels Lodewyk F.A. ,   the Dutch-Belgian VUS workgroup, Vreeswijk Maaike P.G. , Jonkers Jos 
Published: June 2020

Abstract

Purpose:
Because BRCA1 is a high-risk breast/ovarian cancer susceptibility gene, BRCA1 sequence variants of uncertain clinical significance (VUS) complicate genetic counseling. As most VUS are rare, reliable classification based on clinical and genetic data is often impossible. However, all pathogenic BRCA1 variants analyzed result in defective homologous recombination DNA repair (HRR). Thus, BRCA1 VUS may be categorized based on their functional impact on this pathway.

Experimental Design:
Two hundred thirty-eight BRCA1 VUS—comprising most BRCA1 VUS known in the Netherlands and Belgium—were tested for their ability to complement Brca1-deficient mouse embryonic stem cells in HRR, using cisplatin and olaparib sensitivity assays and a direct repeat GFP (DR-GFP) HRR assay. Assays were validated using 25 known benign and 25 known pathogenic BRCA1 variants. For assessment of pathogenicity by a multifactorial likelihood analysis method, we collected clinical and genetic data for functionally deleterious VUS and VUS occurring in three or more families.

Results:
All three assays showed 100% sensitivity and specificity (95% confidence interval, 83%–100%). Out of 238 VUS, 45 showed functional defects, 26 of which were deleterious in all three assays. For 12 of these 26 variants, we could calculate the probability of pathogenicity using clinical and genetic data, resulting in the identification of 7 (likely) pathogenic variants.

Conclusions:
We have functionally categorized 238 BRCA1 VUS using three different HRR-related assays. Classification based on clinical and genetic data alone for a subset of these variants confirmed the high sensitivity and specificity of our functional assays.
Abstract B35: Isolation and characterization of circulating tumor cells (CTCs) from bladder cancer patients using a highly sensitive graphene oxide-based microfluidic device (GO chip)
Authors: Niu Zeqi , Kozminsky Molly A. , Day Kathleen C. , Palmbos Phillip L. , Day Mark L. , Nagrath Sunitha 
Published: June 2020

Abstract
Introduction: A critical research topic in bladder cancer is determining the key regulators in the progression from noninvasive tumor to invasive and ultimately metastatic disease. Although patients with noninvasive bladder cancer can be treated through transurethral resection of bladder tumor and have a high survival rate (~95%), noninvasive bladder tumors recur in 50%-70% of cases. Of these, 10-15% of cases progress to invasive disease. Circulating tumor cells (CTCs) represent the transitional phase of progression between lymphovascular intravasation and distant metastases. Molecular profiling of these CTCs, beyond enumeration, can inform the molecules/pathways important in the invasion process, and potentially help unravel the mechanism of metastasis and provide new targets for therapy. Here we report the application of a highly sensitive graphene oxide-based microfluidic device to isolate and characterize CTCs from bladder cancer patients for the expression of markers implicated in an invasive phenotype.
Methods: An anti-EpCAM and anti-EGFR biotinylated antibody cocktail was immobilized onto the graphene oxide chip (GO chip) to capture CTCs from whole blood. In patient samples, immunofluorescence staining for DAPI (nuclei), cytokeratin (cancer cell marker), EGFR and HER2 (markers of invasive phenotype), and CD45 (white blood cell marker) was used to enumerate CTCs. Cells with a DAPI+CK+CD45- phenotype were counted as CTCs. Blood samples from ten metastatic bladder cancer patients and two healthy controls were processed, stained, and analyzed.
Results: CTCs were found in 10/10 (100%) patients, with an average of 17.70 cells/mL (s = 10.69 cells/mL). 9/10 patients exhibited CTCs that express EGFR, but only one patient had one CTC express HER2.
Conclusion: The antibody-functionalized GO chips were able to successfully capture and enable characterization of CTCs from metastatic bladder cancer patients. EGFR potentially plays an important role in the vascular invasion process.
Citation Format: Zeqi Niu, Molly A. Kozminsky, Kathleen C. Day, Phillip L. Palmbos, Mark L. Day, Sunitha Nagrath. Isolation and characterization of circulating tumor cells (CTCs) from bladder cancer patients using a highly sensitive graphene oxide-based microfluidic device (GO chip) [abstract]. In: Proceedings of the AACR Special Conference on Advances in Liquid Biopsies; Jan 13-16, 2020; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(11_Suppl):Abstract nr B35.
Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage
Authors: Johansson Kristina , Johansson Lars , Pennlert Johanna , Söderberg Stefan , Jansson Jan-Håkan , Lind Marcus M. 
Published: June 2020

Background and Purpose:
Previous observational studies have shown a moderately increased risk of intracerebral hemorrhage (ICH) with high self-reported alcohol consumption. However, self-reported data tend to underestimate alcohol consumption. Phosphatidylethanol is a specific biomarker reflecting alcohol intake during the last month and correlates with the amount of alcohol consumed. The present study aimed to investigate the association between phosphatidylethanol levels and the risk of future ICH.

Methods:
This population-based nested case-referent study was conducted within the Northern Sweden Health and Disease Cohort. At baseline, all participants underwent a health examination, including a questionnaire with questions about alcohol consumption. A blood sample was collected and stored at −80°C, and phosphatidylethanol 16:0/18:1 levels were measured in packed erythrocytes. Cases (n=97) were diagnosed with a first-ever ICH between 1985 and 2007. Two referents (n=180) were matched to each case.

Results:
The mean age at baseline was 55 years, 39% of participants were women, and the mean time from blood sampling to ICH was 7.3 years. Only phosphatidylethanol and hypertension remained independently associated with ICH in a multivariable model. Participants with phosphatidylethanol >0.30 μmol/L had an increased risk of ICH compared with those with phosphatidylethanol <0.01 μmol/L (odds ratio, 4.64 [95% CI, 1.49–14.40]).

Conclusions:
High blood concentrations of phosphatidylethanol were associated with an increased risk of future ICH. This association was independent of hypertension and other risk factors for ICH. Our findings suggest that phosphatidylethanol, as a marker of alcohol consumption, may be used as a risk marker of future ICH.
The ecological preferences of Eurytemora affinis (Poppe, 1880) in the water bodies of Kazakhstan (Central Asia) and some notes about Eurytemora caspica Sukhikh & Alekseev, 2013
Authors: Krupa Elena G. 
Published: June 2020

Abstract
The purpose of this work is to analyse the influence of external factors on quantitative variables of Eurytemora affinis in water bodies of Kazakhstan. In 1997-2018, more than 150 water bodies located in various regions of the country were surveyed. The results obtained and analysis of the published literature showed that E. affinis primarily inhabits small shallow water bodies of Central and Eastern Kazakhstan. Populations from the North-Eastern Caspian Sea, originally identified as “Eurytemora affinis”, could be attributed to the recently described species Eurytemora caspica. In the water bodies examined, E. affinis was found at water temperatures from 12 to 25°C and at salinities from 0.2 to 7.1 g/dm3. The highest abundance of Eurytemora was recorded at 21-22°C and a salinity of 1.0-3.0 g/dm3. The optimum temperature range in the water bodies examined in an extreme continental climate is higher than the values given for E. affinis in water bodies in a moderately temperate climate. The optimal TDS [Total Dissolved Solids] value (1.0-3.0 g/dm3) has shifted towards more truly fresh waters than was stated for E. affinis collected from the sea (6.2-8.2), and this was confirmed in experiments (from 3.0-10.0 to 10.0-15.0). In the majority of the examined water bodies of Kazakhstan, males dominated the Eurytemora populations. Male dominance in E. affinis populations might be due to the adverse effect of elevated temperature on the lifespan of females, and it was also connected with the level of toxic pollution of the water bodies. It seems that E. affinis endures a relatively high content of heavy metals, but it does not inhabit water bodies with very high toxic pollution. The revealed features of E. affinis’ biology in Kazakhstan water bodies might be associated with both the heterogeneity of its populations from different parts of the range, and the existence of a complex of closely related species that at present is collectively named “Eurytemora affinis”.