bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-World Evidence of Clinical Outcomes in Precision Radionuclide Oncology: The NIGHTCAP Study of 177Lu-PSMA in Metastatic Prostate Cancer
Authors: Turner J. Harvey 
Published: March 2020

:
A novel approach to current radiopharmaceutical study design to document the efficiency of 177Lu-
PSMA-radioligand therapy of metastatic prostate cancer is described in a proposed prospective, real-time, realworld
audit of a large patient population worldwide. The NIGHTCAP (National Investigators Global Harmonisation
Theragnostics of Cancer of Prostate) Study will establish real-world evidence (RWE) of overall survival
(OS) and quality of life (QoL) in patients undergoing routine 177Lu-PSMA-radioligand therapy on harmonised
compassionate patient-usage protocols throughout the world. Such long-term efficiency data will be contrasted
with the short-term randomised controlled trial (RCT) assessments of efficacy predicated upon surrogate markers
of survival outcomes, such as progression-free survival (PFS). The shortcomings of RCT evaluation of the clinical
benefit of new anticancer agents are detailed in this review, which advocates RWE to determine efficiency.

:
The real-time monitoring of QoL in the NIGHTCAP Study is independent of questionnaires, language differences,
or oncologist bias, and relies upon individual patient self-assessment by choice of one of five emoji which
best reflects their mood each day.
Evaluation of Hepatoprotective Activity of Clerodendrum paniculatum Leaf on Carbon Tetrachloride-Induced Liver Toxicity Model in Swiss Albino Rats and Its Characterization by GC-MS
Authors: Kopilakkal Remya , Musuvathi Balamurali M. 
Published: March 2020

Background:Clerodendrum paniculatum has ethnomedicinal importance in treatment of disorders like wound, typhoid, jaundice, malaria and anemia.Objective:To evaluate the antioxidant and hepatoprotective activity of Clerodendrum paniculatum leaves against carbon tetrachloride (CCl4) induced rat model and identification of its bioactive constituents by Gas Chromatography Mass Spectroscopy (GC MS).Methods:Successive solvent extraction was carried out. Total phenolic, flavonoid content and antioxidant activity by 2,2- diphenyl-1-picryl hydrazyl (DPPH), nitric oxide and 2-Azino-bis [3-ethyl benzothiazoline- 6-sufonic acid] (ABTS method) were done. Ethyl acetate extract was selected for hepatoprotective study in carbon tetrachloride intoxicated model followed by the measurement of liver function marker enzymes such as SGOT (Serum Glutamate Oxaloacetate Transaminase), SGPT (Serum Glutamate Pyruvate Transaminase), and ALP (Alkaline Phosphatase). Biochemical parameters like bilirubin and protein were measured. Histopathologic liver sections were carried out. Bioactive constituents were evaluated by GC MS.Results:By DPPH and ABTS method, ethyl acetate extract showed IC50 as 70.14±0.92 μg/ml,2958.24±2.460 μg/ml, respectively. The alcoholic extract showed maximum IC50 (197.22 ±7.16 μg/ml) by Nitric oxide radical scavenging method. Hepatoprotective study reveals that intoxicated animal groups have elevated levels of enzymes and bilirubin and suppress the production of protein. The extract pre-treatment showed a significant decrease in enzymes and increased production of total protein in a dose-dependent manner. Histopathologic studies also support the hepatoprotective activity. GC MS analysis revealed the presence of seven major bioactive constituents with ethyl palmitate as the major one.Conclusion:The results support the proof for the hepatoprotective potential of the CPLE extract with potent antioxidant activity and enhanced liver enzyme level. The observed activity could be due to the presence of bioactive compounds as identified by GC MS analysis.
Use of Nanoparticles in Medicine
Authors: Utreja Puneet , Verma Shivani , Rahman Mahfoozur , Kumar Lalit 
Published: March 2020

Background:
Nanotechnology involves the study of materials having dimensional range 1
to 100 nm. When the concept of nanotechnology is applied in the medical field, the resulting outcome
is known as ‘Nanomedicine’. Nanomedicine generally includes nanoparticles, which are explored for
various therapeutic applications. Various properties of nanoparticles like high reactivity, large surface
area, and ultra small size make them highly efficient compared to conventional therapeutic agents.

Methods:
Present review discloses applications of various nanoparticulate systems in drug delivery
and therapeutics. We searched nanoparticulate systems like liposomes, polymeric nanoparticles, lipidic
nanoparticles, dendrimers, carbon nanotubes, and gold nanoparticles using search engines like
PubMed and Google Scholar.

Results:
Results of a literature review regarding the use of nanoparticulate systems revealed their high
preclinical efficacy, safety, and reduced toxicity compared to various traditional systems used for the
delivery of various therapeutic agents. Implementation of targeting moieties like peptides, antibodies,
or aptamers in nanoparticulate systems shows a synergistic effect in their efficacy.

Conclusion:
Nanoparticulate systems have shown significant effects on different areas of the medical
field. However, clinical exploration of various nanoparticulate systems is still a challenge and this fact
should be taken into consideration by pharmaceutical scientists. Despite this, nanomedicine is expected
to have a tremendous effect on various areas of the medical field in the future.
Vitamin C Loaded Chemically Modified Nano Carrier for Human Health Care Application
Authors: Sengupta Monalisha , Shaharyar Md. Adil , Rahman Mahfoozur , Anand Kumar , Kundu Anindita 
Published: March 2020

Background:“Health is wealth” and to maintain it 7 essential nutrients are required. Among these, Vitamin is one that has great importance in very low concentration. As per the solubility, it divides into water-soluble and water-insoluble vitamins. This study concentrates on Vitamin C, a water-soluble vitamin which is essential for human growth due to its activity in the synthesis of carnitine, collagen, and neurotransmitter. It possesses antioxidant, antiatherogenic, and immunomodulatory functions, which may lead to the activity of Vitamin C in many diseases. But humans and some other non-human primates are unable to produce Vitamin C from glucose due to the absence of enzyme gulonolactone oxidase. As a result, humans are dependent on various dietary sources of Vc especially citrus fruit. But these dietary supplies also fail to achieve the required level in the body due to its poor bioavailability and storage.Method:Vitamin C has already proven its activity in cancer therapy. It is also used as a prodrug of H2O2. But due to the poor bioavailability and storage of Vitamin C in the human body, mankind is unable to avail the benefits of Vitamin C. These problems lead to generating different and suitable nanoformulations to incorporate Vitamin C and its derivatives into it. Different research work shows several ways to develop nanoformulations. Amongst all liposomes, microsphere, nanocarriers are of great importance. For Vitamin C incorporation into the nanoformulation, nanocarriers become the most popular choice for researchers. There were several nanocarrier systems developed using Chitosan- Alginate, Silica-Coated-Au Nanoparticles, Chitosan, Mesoporous-silica NCs for suitable incorporation of Vitamin C into these. The performances were assured by performing different in vitro and in vivo tests which will be discussed here.Result:As a result, Vitamin C is now in use for many purposes. It includes not only the above mentioned functions but also other functions too. Due to an antioxidant property, Vitamin C is able to quench reactive oxygen species (ROS) by inhibiting ROS-mediated Nitric Oxide (NO) inactivation. Vitamin C helps to elevate the level of absorption of iron within the cell from dietary iron sources. It also prevents the oxidation of drugs. To achieve all these functions, NCs or nanoformulation plays a great role.Conclusion:It can be concluded that depending on the biocompatibility, loading capacity, protection of the loading molecule, efficiency of cellular uptake, controllable rate of release to achieve the desired effect, and many more factors, the choice of different Nanocarriers (NCs) will be done which ultimately help the human to use it for different purposes. This paper tries to gather some information in one place with respect to different experimental studies.
FEATURES OF PAIN SYNDROME IN PATIENTS WITH MULTIPLE SCLEROSIS
Authors: Maksymchuk L. T. , Gryb V. A. , Doroshenko O. O. , Genyk S. I. , Gerasymchuk V. R. , Sorokhman A. V. 
Published: March 2020

The data of 61 medical cards of patients with multiple sclerosis has been analyzed. 47,54% of patients reported pain as a symptom of multiple sclerosis, following types of pain were observed: neuropathic pain (оngoing extremity pain, Lhermitte's phenomenon), nociceptive pain (headache, back pain) and mixed pain (painful tonic spasms, spasticity pain). Only 17,24% of patients received therapy to treat pain.
THE STATE OF CHANGES IN THE BIOELECTRICAL ACTIVITY OF THE BRAIN IN PATIENTS UNDERGOING SURGERY USING GENERAL ANESTHESIA WITH STANDART MANAGEMENT OF THE POSTOPERATIVE PERIOD
Authors: Tovazhyanskaya O. L. , Dubivska S. S. , Grigorov Yu. B. , Solovyova E. T. 
Published: March 2020

The purpose of this work is to determine the functional state of the brain of patients on the basis of the electroencephalogram, which were operated under general anesthesia against the background of the standard management of the postoperative period.
The study was conducted in the surgical departments of various profiles on the basis of the Kharkov City Clinical Hospital of Emergency and Emergency Medical Care. prof. A.I. Meshchaninov.
The study was conducted with the total number of patients in 86 young, middle-aged and elderly patients with surgical pathology who underwent surgery under general anesthesia.
The study of the functional state of the brain by determining the bioelectrical activity of the brain, by conducting an electroencephalogram, was determined in two stages: before surgery and 3-5 days after surgery with general anesthesia.
Based on the data obtained, it is possible to recommend an electroencephalogram to assess the functional state of the brain of patients undergoing surgery under general anesthesia. Marked electroencephalographic changes in the period after the operation indicate a deterioration in the functional state of the brain, which are a consequence of the effects of anesthesia, surgical stress, and effects on cognitive function.
THE PHENOMEN DIGNITARY OF THE NATION IAKOV MAKOGІN
Authors: Henyk S. M. 
Published: March 2020

Galichanin from Lviv region in the search of better fate it turns out abroad ocean gets american citizenship and passes military units elite units american army.
To meate with pure american girl Syusann wihich fall in love handsome, healthy, clever and well-bread Ukrainian boy. Girl is the only one daughter one the richest one of the most rich american. Demobilization after 15 years service in the marine corps – there lound wedding. Get’s direct ucces to father’s money, new part of family throught many years uses then not for future enrichment or comfort but for solution of the older "Ukrainian question" in the most dramatic period stays Ukrainian AVG consisting of Soviet imperia. That which is done abroad to the call of the heart this ukrainian boy can outmatch a work complex embassy a big country.
ENDOTHELIAL DYSFUNCTION IN TRANSIENT ISCHEMIC ATTACK IN THE VERTEBRAL-BASILAR SYSTEM
Authors: Henyk S. I. , Gryb V. A. , Maksymchuk L. T. , Doroshenko O. O. , Henyk Ya. I. 
Published: March 2020

Transient ischemic attack (TIA) in the vertebral-basilar system (VBS) is characterized by an acute onset of focal neurological symptoms due to short-term local ischemia of the brain. According to various authors, temporary neurological manifestations of circulatory insufficiency in VBS can progress to complete stroke within 2-5 years in 30-50% of patients, leading to disability of about 80% of patients. Its diagnosis is associated with some difficulties due to the variability of clinical manifestations, clinical similarity with other diseases and, as a consequence, incorrect therapeutic tactics.
The aim of the study was to investigate changes of endothelial function in TIA in VBS by determining the levels of homocysteine (HC) and vascular endothelial growth factor (WEGF) at different stages of neurological deficiency (ND). 78 patients with TIA in VBS were examined. The questionnaire developed by us was used to determine the stage of ND in TIA. The level of HC was determined by enzyme-linked immunosorbent assay. WEGF was determined using the "sandwich" method of enzyme-linked immunosorbent assay. In the group of patients with stage I ND, a tendency to HC increase in 1.1 times was detected compared with almost healthy persons (AHP), stage II - HC increased in 1.5 times (p <0.05), and stage III - in 1.9 times (p <0.05). Also significant difference (1.8 times) was revealed at stage III compared to the index of stage I (p <0.05). WEGF at the 1st stage of ND significantly increased in 1,7 times in comparison with AHP (p <0.05), at the 2nd stage there was a tendency to increase (in 1.2 times), at the 3d stage there was a significant increase in WEGF in comparison with AHP (in 2.9 times) (p <0.05), and compared with indicators of I (in 1.8 times) (p <0.05) and II stages (2.6 times) (p <0 , 05).
We have shown that TIA in VBS is accompanied by endothelial dysfunction (increase in HC and WEGF), which is more pronounced with aggravation of the ND. To evaluate the prognosis of the disease, we recommend using a questionnaire for determination the stage of ND in TIA in VBS and to identify markers of endothelial function such as HC and WEGF.
Re-examination of Rule-Based Methods in Deidentification of Electronic Health Records: Algorithm Development and Validation
Authors: Zhao Zhenyu , Yang Muyun , Tang Buzhou , Zhao Tiejun 
Published: March 2020

Background
Deidentification of clinical records is a critical step before their publication. This is usually treated as a type of sequence labeling task, and ensemble learning is one of the best performing solutions. Under the framework of multi-learner ensemble, the significance of a candidate rule-based learner remains an open issue.

Objective
The aim of this study is to investigate whether a rule-based learner is useful in a hybrid deidentification system and offer suggestions on how to build and integrate a rule-based learner.

Methods
We chose a data-driven rule-learner named transformation-based error-driven learning (TBED) and integrated it into the best performing hybrid system in this task.

Results
On the popular Informatics for Integrating Biology and the Bedside (i2b2) deidentification data set, experiments showed that TBED can offer high performance with its generated rules, and integrating the rule-based model into an ensemble framework, which reached an F1 score of 96.76%, achieved the best performance reported in the community.

Conclusions
We proved the rule-based method offers an effective contribution to the current ensemble learning approach for the deidentification of clinical records. Such a rule system could be automatically learned by TBED, avoiding the high cost and low reliability of manual rule composition. In particular, we boosted the ensemble model with rules to create the best performance of the deidentification of clinical records.
La reescritura de "La Bella Durmiente" en The Infernal Desire Machines of Doctor Hoffman, de Angela Carter
Authors: Piñeiro Carballeda Aurora 
Published: March 2020

El objetivo de este ensayo es hacer una lectura de la novela The Infernal Desire Machines of Doctor Hoffman, de la escritora inglesa Angela Carter, como una reescritura de “La Bella Durmiente del bosque”, entre otras fuentes muy reconocidas en la tradición de las literaturas europeas. Al llevar a cabo este análisis se puede apreciar la manera en que la autora hacía de la reescritura una herramienta específicamente posmoderna y una estrategia para la denuncia de las relaciones de poder en el ámbito social, así como en la práctica misma de la lectura, como una actividad en la que se reproduce el binomio mirada-poder.
De la novella bocacciana a las Novelas ejemplares
Authors: Stoopen Galán María 
Published: March 2020

Dado que Miguel de Cervantes en el título y el Prólogo a sus Novelas ejemplares le otorga al término novela un valor fundacional tanto en su narrativa comoen la historia de la prosa española, aquí atenderé las condiciones de la difusión de la novella italiana en España. Me ocuparé también del significado que Cervantes fue definiendo a lo largo de su producción literaria no sólo del vocablo heredado de la lengua toscana —novella—, sino del género mismo. Finalmente, analizaré la filiación bocaciana del escritor español al inicio de su trabajo novelístico y destacaré la manera como en su práctica se distanció de ella cultivando con originalidad temas y géneros hispánicos, así como procedentes de otras tradiciones.
Literatura francesa de la contemporaneidad y del extremo-contemporáneo
Authors: Landais Choimet Monique 
Published: March 2020

Tratar de dar cuenta de la literatura francesa contemporánea y, más todavía, del extremo-contemporáneo, no resulta fácil por dos razones: la falta de distanciamiento y la escasez de referentes teóricos y críticos. Pero el mismo atrevimiento inherente a la empresa hizo que ésta resultara muy atractiva. De hecho, la paradoja que se impone como la figura matricial del presente artículo, bien parece estructurar el pensamiento de nuestra época: gracias a la web, nuestra realidad se percibe y se vive cada vez más en modo acrónico y atópico. Dicha peculiaridad contemporánea nos llevó a establecer una relación dialógica a través de los tiempos y espacios para resaltar cierta tendencia a la armonía y a la concordia en materia de continuum literario, más allá de las innovaciones medulares y de los préstamos tradicionales.
The World’s Wife, de Carol Ann Duffy
Authors: Fe Marina , Cruz Yañez Eva 
Published: March 2020

Carol Ann Duffy nació en Glasgow, Escocia, en 1955. En 2009 fue la primera mujer nombrada Poeta Laureada en el Reino Unido. Ha recibido varios premios por sus libros de poesía, entre los que se encuentran: Standing Female Nude, 1985; Selling Manhattan, 1987; The Other Country, 1990; Mean Time, 1993; The World’s Wife, 1999; Feminine Gospels, 2002; Rapture, 2005, y The Bees, 2011. Hemos querido dar a conocer algunos poemas de su colección de The World’s Wife, poemas subversivos que cuestionan y desconstruyen los mitos acerca de ciertos “grandes hombres”, ya sean personajes históricos o ficcionales, desde el punto de vista de las mujeres. En esta suerte de coro femenino se encuentran, por ejemplo, las esposas de Esopo, Darwin, Fausto, Tiresias, Quasimodo, Lázaro, Shakespeare, Midas y hasta el mismo Diablo. Aparecen también otras que no son esposas, como Medusa, Caperucita Roja y la estatua de Pigmalión. Como parte de un proyecto de traducción más ambicioso de la obra poética de Duffy, ofrecemos aquí una selección de estos poemas, una breve muestra de su ingenio, su humor, su actitud crítica y a veces satírica, así como del lirismo que recorre, sin duda, toda su obra.
Declaration for Open Science and Research 2020–2025
Authors: Avoimen tieteen koordinaatio  
Published: March 2020

The Declaration for Open Science and Research presents a common vision for the Finnish research community. This vision states that open science and research should be integrated in researchers’ everyday work and support not only the effectiveness of research outputs but also the quality of research. Furthermore, the vision sees the Finnish research community as an international forerunner in open science and research.
The path toward the vision is described in a mission for Open Science and Research. The mission is:

to promote openness as a fundamental value throughout the research community and its activities
to strengthen societal knowledge base and innovation and
to improve the quality of scientific and artistic research outputs and the educational resources based on them, and the fluid mobility and impact of research outputs throughout society between researchers and research teams, between fields of science and research, between research and education, between researchers and the private sector, the public sector and the third sector, and between researchers and society’s decision makers and citizens.
The Role of Social Capital in Shaping Europeans’ Immigration Sentiments
Authors: Economidou Claire , Karamanis Dimitris , Kechrinioti Alexandra , Xesfingi Sofia 
Published: March 2020

Abstract
Migration has manifested itself to historic highs, creating divisive views among politicians, policy makers, and individuals. The present paper studies the Europeans’ attitudes toward immigration, focusing particularly on the role of social capital. Based on 267,282 respondents from 22 countries and over the period 2002–2014, we find that despite the eventful past years, Europeans, on average, are positive toward immigrants with the North European countries to be the least xenophobic. A salient finding of our analysis is that regardless of the impact of other contextual factors, namely, a country’s macroeconomic conditions, ethnic diversity, cultural origin, and individuals’ attributes, social capital associates with positive attitudes toward all immigrants, independent of their background. Furthermore, social capital moderates the negative effects of perceived threat on people’s opinions about immigrants.
Point-of-service diagnostic technology for detection of swine viral diseases
Authors: Nannucci Lapo , Barattini Paolo , Bossis Ioannis , Woźniakowski Grzegorz , Balka Gyula , Pugliese Carolina 
Published: March 2020

Abstract

Introduction
A research project is underway aiming to develop a field diagnostic tool for six important viruses of the pig sector, namely: African swine fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), porcine parvovirus (PPV), porcine circovirus (PCV2), and classical swine fever virus (CSFV).

Material and Methods
To obtain a preliminary sounding of the interest in this type of instrument among its potential operators, a questionnaire was drawn up and submitted to three categories of stakeholders: farmers, veterinarians, and others (including scientific and technical staff working on animal farms). Four countries participated: Italy, Greece, Hungary, and Poland.

Results
In total, 83 replies were collected and analysed in a breakdown by stakeholder type and pertinence, where the areas were the importance of the main diseases within the different countries, diagnostic tool operational issues, and economic issues.

Conclusion
The main end-users of this kind of instrument are expected to be private veterinarians and pig producers. The infectious agents seeming to be most interesting to diagnose with the instrument are PRRSV, SIV, PPV, and PCV2. The most decisive parameters which have been selected by the stakeholders are sensitivity, cost, simplicity, and time required to obtain results. The economic issue analysis showed that the majority of those who would prefer to buy rather than rent the device are willing to pay up to €3,000 for a diagnostic field tool.