bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Production of Metal–Organic Frameworks Based Separators in Industrial‐Level Efficiency
Authors: Gao Guang‐Kuo , Wang Yi‐Rong , Zhu Hong‐Jing , Chen Yifa , Yang Ru‐Xin , Jiang Cheng , Ma Huiyuan , Lan Ya‐Qian 
Published: November 2020

AbstractMetal–organic framework (MOF) based mixed matrix membranes (MMMs) have received significant attention in applications such as gas separation, sensing, and energy storage. However, the mass production of MOF‐based MMMs with retained porosity remains a longstanding challenge. Herein, an in situ heat‐assisted solvent‐evaporation method is described to facilely produce MOF‐based MMMs. This method can be extended into various MOFs and polymers with minimum reaction time of 5 min. Thus‐obtained MMMs with high uniformity, excellent robustness, well‐tuned loading, and thickness can be massively produced in industrial‐level efficiency (≈4 m in a batch experiment). Furthermore, they can be readily applied as powerful separators for Li–S cell with high specific capacity (1163.7 mAh g−1) and a capacity retention of 500.7 mAh g−1 after 700 cycles at 0.5 C (0.08% fading per cycle). This work may overcome the longstanding challenge of processing MOFs into MMMs and largely facilitate the industrialization process of MOFs.
Meeting the challenge of water sustainability: The role of process systems engineering
Authors: Shah Sirish L. , Bakshi Bhavik R. , Liu Jinfeng , Georgakis Christos , Chachuat Benoit , Braatz Richard D. , Young Brent R. 
Published: November 2020

AbstractThis white paper is the result of discussions during the FIPSE‐4 conference (http://fi-in-pse.org) in June 2018. It aims to highlight open problems and provide directions for future research in the area of water with emphasis on its agricultural usages. Some of the open problems discussed are: (a) the use of ecosystems as unit operations to understand their role in providing freshwater and in cleaning polluted water; (b) consideration of interactions and independencies between flows of water and other resources, such as food, energy, materials, ecosystem services, and environmental emissions; (c) challenges in modeling, sensing, and closed‐loop control in precision irrigation. In particular, the development of agro‐hydrological models that balance computing speed versus solution details and accuracy: (d) The use of state and parameter estimation approaches, through field measurements, to obtain soil moisture levels accurately; and (e) decision support systems to administer water and nutrient needs for optimum yields of agricultural products.
Body composition helps: Differences in energy expenditure between pregnant and nonpregnant females
Authors: Prado‐Nóvoa Olalla , Rodríguez Jesús , Martín García Adrián , Mateos Ana 
Published: November 2020

AbstractObjectivesHuman pregnancy is associated with important physiological changes that usually increase energetic requirements. However, great variability exists in the costs and mechanisms required to bear pregnancy. Since body mass (BM) and composition are modified during gestation, it is of great interest to compare the influence of BM on energy expenditure (EE) in pregnant and nonpregnant females.MethodsBM, body composition, and EE of 77 volunteers (35 pregnant and 42 nonpregnant females) were measured. The pregnant volunteers completed two measurement rounds at 28 and 32 gestation weeks. Differences on the measured parameters were sought, and comparison of regression lines was computed to test how BM affected the EE of the volunteers.ResultsBM and body composition parameters are significantly higher in pregnant females, but EE is not statistically different. Pregnant females have a larger percentage of fat mass, but lower percentage of fat‐free mass (FFM). The EE per kg of FFM is similar in both groups. Comparison of regression lines shows that pregnancy does not change the relationship between BM and EE, but for similar BM pregnant females expend less energy than nonpregnant females.ConclusionsWe propose that their larger percentage of passive body tissues is the reason why pregnant females expend less energy than nonpregnant females of similar BM, without changing the scaling of EE on BM. Thus, pregnancy could not be as energetically constraining as usually assumed, with important consequences for human reproductive ecology.
Self‐reported and objectively measured occupational exposures, health, and safety concerns among fishermen: A cross‐sectional Fishing Industry Safety and Health (FISH) pilot study
Authors: Santiago Katerina M. , Louzado‐Feliciano Paola , Baum Jeramy , Bakali Umer , Caban‐Martinez Alberto J. 
Published: November 2020

AbstractBackgroundFishing industry workers are exposed to hazardous working conditions, engage in strenuous labor, and work long hours in variable weather conditions. Despite these known employment challenges, little is known of their perceived occupational health and safety concerns. In this pilot study, we: (1) describe fishermen's perceptions on worker‐ and organizational‐level characteristics that impact occupational health and safety; and (2) estimate environmental exposure to polycyclic aromatic hydrocarbons (PAHs) encountered during fishing activities.MethodsWe collected both qualitative and quantitative data from Mississippi and Florida fishermen. Using an ethnographic approach, the study team conducted 1‐h key informant interviews, administered a one‐page demographic survey, and collected objective measurements to PAHs using silicone‐based passive sampling wristbands.ResultsStudy participants (n = 17) had a mean age of 50.9 years (SD = 11.7), 88.2% were male, 94.1% white, 100.0% non‐Hispanic/Latino, and 52.9% were married. Approximately, 87.5% reported fishing as their primary job, with a mean of 26.4 years in the industry (SD = 15.3). Four broad themes describing the culture of the fishing industry, common workplace exposures that impact fishermen's safety and health, and facilitators and barriers to safety while working in the fishing industry were documented. Deckhands had the lowest mean exposure to PAHs (8.3 ppb), followed by crew members (11.0 ppb), captains (82.64 ppb), and net makers (208.1 ppb).ConclusionsGulf coast fishermen expressed specific occupational health and safety concerns and were exposed to carcinogenic PAHs during regular work. Opportunities exist and strategies are needed for health protection and health promotion interventions among Gulf fishermen.
An Ethacrynic Acid‐Brominated BODIPY Photosensitizer (EA‐BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor‐Targeted Photodynamic Therapy
Authors: Won Miae , Koo Seyoung , Li Hao , Sessler Jonathan L. , Lee Jin Yong , Sharma Amit , Kim Jong Seung 
Published: November 2020

AbstractDespite being a clinically approved intervention for cancer, photodynamic therapy (PDT) still suffers from limitations. Prime among these is a therapeutic response that is mostly oxygen dependent. This limits the utility of PDT in treating hypoxic tumors since lower levels of cytotoxic reactive oxygen species (ROS) are generated in regions of low oxygen tension. Glutathione‐pi (GST‐pi) is a key enzyme that militates against ROS‐mediated apoptosis. We report herein a new construct, EA‐BPS, that contains both a brominated BODIPY photosensitizer (BPS) and an ethacrynic acid (EA) GST‐pi inhibitor. Photoirradiation of EA‐BPS induces a synergistic antitumor effect that results from the combination of ROS production and GST‐pi inhibition. Relative to BPS alone, an enhanced cell‐killing effect is seen under hypoxic conditions both in vitro and in vivo. We conclude that by making better use of the available oxygen in tumor environments, improved therapeutic PDT outcomes should be achievable even under hypoxic conditions.
Reversible Activation and Transfer of White Phosphorus by Silyl‐Stannylene
Authors: Sarkar Debotra , Weetman Catherine , Munz Dominik , Inoue Shigeyoshi 
Published: November 2020

AbstractUse of a silyl supported stannylene (MesTerSn(SitBu3) [MesTer=2,6‐(2,4,6‐Me3C6H2)2C6H3] enables activation of white phosphorus under mild conditions, which is reversible under UV light. The reaction of a silylene chloride with the activated P4 complex results in facile P‐atom transfer. The computational analysis rationalizes the electronic features and high reactivity of the heteroleptic silyl‐substituted stannylene in contrast to the previously reported bis(aryl)stannylene.
High‐Efficiency Perovskite Solar Cells with Imidazolium‐Based Ionic Liquid for Surface Passivation and Charge Transport
Authors: Zhu Xuejie , Du Minyong , Feng Jiangshan , Wang Hui , Xu Zhuo , Wang Likun , Zuo Shengnan , Wang Chenyu , Wang Ziyu , Zhang Cong , Ren Xiaodong , Priya Shashank , Yang Dong , Liu Shengzhong (Frank) 
Published: November 2020

AbstractSurface defects have been a key constraint for perovskite photovoltaics. Herein, 1,3‐dimethyl‐3‐imidazolium hexafluorophosphate (DMIMPF6) ionic liquid (IL) is adopted to passivate the surface of a formamidinium‐cesium lead iodide perovskite (Cs0.08FA0.92PbI3) and also reduce the energy barrier between the perovskite and hole transport layer. Theoretical simulations and experimental results demonstrate that Pb‐cluster and Pb‐I antisite defects can be effectively passivated by [DMIM]+ bonding with the Pb2+ ion on the perovskite surface, leading to significantly suppressed non‐radiative recombination. As a result, the solar cell efficiency was increased to 23.25 % from 21.09 %. Meanwhile, the DMIMPF6‐treated perovskite device demonstrated long‐term stability because the hydrophobic DMIMPF6 layer blocked moisture permeation.
Effects of modified poly(tetrafluoroethylene) on the physico‐mechanical and tribological properties of carbon‐black filled nitrile‐butadiene rubber
Authors: Jafari Farid , Razzaghi‐Kashani Mehdi , Hosseini Seyed Mostaffa , Pourhossaini Mohammad Reza 
Published: November 2020

AbstractIn this study the effects of electron beam irradiated poly (tetrafluoroethylene) (IR‐PTFE) on the mechanical and tribological properties as well as thermal and solvent aging behavior of carbon black filled nitrile‐butadiene rubber vulcanizates were studied. Based on the obtained results, addition of 30phr IR‐PTFE reduced mechanical strength about 10%, whereas coefficient of friction desirably reduced up to 60%. It was shown that IR‐PTFE significantly improved tribological properties by affecting the adhesion contribution of the friction mechanism. Moreover, formation of IR‐PTFE transfer films also contributed to the reduction of coefficient of friction in the long term tests. In addition, it was explained that IR‐PTFE enhances the sulfur cross‐linking reaction in the vulcanizates by reducing the intensity of carbon black network. Therefore, augmented chemical cross‐links compensates the loss of physical cross‐links in the carbon black network and keeps the solvent swelling resistance unchanged. Also, IR‐PTFE showed positive effects on the solvent aging of the vulcanizates, whereas the thermal aging of vulcanizates was unaffected.
Development of biphenyl monomers and associated crosslinked polymers with intramolecular pi‐pi interactions
Authors: Shah Rishabh A. , Ostertag Thomas W. , Tang Shuo , Dziubla Thomas D. , Hilt J. Zach 
Published: November 2020

AbstractMonomers containing biphenyl moieties were employed to create two sets of covalently crosslinked polymers that displayed noncovalent interactions in their 3‐dimensional network. The biphenyls (precursors) used were 2‐phenylphenol, 4‐phenylphenol and 4,4′‐dihydroxybiphenyl, and their acrylated forms were synthesized and named as 2‐phenylphenolmonoacrylate, 4‐phenylphenolmonoacrylate, and 4,4′‐dihydroxybiphenyldiacrylate, respectively. These were characterized by differential scanning calorimetry, nuclear magnetic resonance, and Fourier transform infrared spectroscopy to confirm the successful acrylation reaction. Polymers were synthesized via free radical polymerization reactions with varying crosslinker contents, and their network properties were characterized using swelling studies and compressive modulus tests. Interestingly, swelling studies did not show the expected decreasing swelling ratio with increasing crosslinker content, while compression testing indicated the expected trend of increasing modulus with increasing crosslinking density. The unexpected swelling results are hypothesized to result from the intramolecular interactions between the biphenyl side groups that result in noncovalent crosslinks.
Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors
Authors: Kalaycı Muharrem , Türkeş Cüneyt , Arslan Mustafa , Demir Yeliz , Beydemir Şükrü 
Published: November 2020

AbstractAlzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, memory impairment, cognitive dysfunction, and speech impairment. The utility of cholinergic replacement by acetylcholinesterase (AChE) inhibitors in AD treatment has been well documented so far. Recently, studies have also evidenced that human carbonic anhydrases (hCAs) serve as an important target for AD treatment. In this direction, the improvement of new multitarget drugs, which can simultaneously modulate several mechanisms or targets included in the AD pathway, may be a potent strategy to treat AD. In light of these data for understanding and developing AD‐related multitarget AChE and hCAs inhibitors, in this study, novel methylene‐aminobenzoic acid and tetrahydroisoquinolynyl‐benzoic acid derivatives (4a–g and 6a–g) were designed. The synthesized analogs were experimentally validated for their effects by in vitro and direct enzymatic tests. Also, the compounds were subjected to in silico monitoring with Schrödinger Suite software to assign binding affinities of potential derivatives based on Glide XP scoring, molecular mechanics‐generalized Born surface area computing, and validation by molecular docking. The results revealed that 6c (1,3‐dimethyldihydropyrimidine‐2,4‐(1H,3H)‐dione‐substituted, KI value of 33.00 ± 0.29 nM), 6e (cyclohexanone‐substituted, KI value of 18.78 ± 0.09 nM), and 6f (2,2‐dimethyl‐1,3‐dioxan‐4‐one‐substituted, KI value of 13.62 ± 0.21 nM) from the benzoic acid derivatives in this series were the most promising derivatives, as they exhibited a good multifunctional inhibition at all experimental levels and in the in silico validation against hCA I, hCA II, and AChE, respectively, for the treatment of AD.
Tensor product transformation‐based modeling of an induction machine
Authors: Németh Zoltán , Kuczmann Miklós 
Published: November 2020

AbstractThe paper demonstrates a tensor product (TP) model transformation‐based framework for an induction machine (IM). The state space model of an IM is highly nonlinear, thus the Takagi–Sugeno (TS) fuzzy model‐based quasi‐linear parameter‐varying (qLPV) representation can be a good alternative approach of machines modeling. The paper presents the basics of IM state space modeling, how the TP transformation can be applied in details. The control of IM is always a pivotal point; hence, options of feedback control are discussed. The main goal of this paper is to present the whole process of IM TP transformation‐based modeling including a control system.
A graphical diagnostic for heavy tailed data
Authors: Nolan John P. 
Published: November 2020

AbstractGraphical diagnostics are described for general heavy tailed data. This tool allows for a model free assessment of the tails of a univariate dataset a transform on the tails of the data. In addition, one can add to the basic plots comparisons of a dataset to multiple models. Multivariate extensions are described using an ordering based on distance from a center.
Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions
Authors: Wang Lei , Yu Jiaojiao , Wang Chih‐chen 
Published: November 2020

AbstractProtein disulfide isomerase (PDI) is one of the most abundant and critical protein folding catalysts in the endoplasmic reticulum of eukaryotic cells. PDI consists of four thioredoxin domains and interacts with a wide range of substrate and partner proteins due to its intrinsic conformational flexibility. PDI plays multifunctional roles in a variety of pathophysiological events, both as an oxidoreductase and a molecular chaperone. Recent studies have revealed that the conformation and activity of PDI can be regulated in multiple ways, including posttranslational modification and substrate/ligand binding. Here, we summarize recent advances in understanding the function and regulation of PDI in different pathological and physiological events. We propose that the multifunctional roles of PDI are regulated by multiple mechanisms. Furthermore, we discuss future directions for the study of PDI, emphasizing how different regulatory modes are linked to the conformational changes and biological functions of PDI in the context of diverse pathophysiologies.
Models for human porphyrias: Have animals in the wild been overlooked?
Authors: de Oliveira Neves Ana Carolina , Galván Ismael 
Published: November 2020

AbstractHumans accumulate porphyrins in the body mostly during the course of porphyrias, diseases caused by defects in the enzymes of the heme biosynthesis pathway and that produce acute attacks, skin lesions and liver cancer. In contrast, some wild mammals and birds are adapted to accumulate porphyrins without injurious consequences. Here we propose viewing such physiological adaptations as potential solutions to human porphyrias, and suggest certain wild animals as models. Given the enzymatic activity and/or the patterns of porphyrin excretion and accumulation, the fox squirrel, the great bustard and the Eurasian eagle owl may constitute overlooked models for different porphyrias. The Harderian gland of rodents, where large amounts of porphyrins are synthesized, presents an underexplored potential for understanding the carcinogenic/toxic effect of porphyrin accumulation. Investigating how these animals avoid porphyrin pathogenicity may complement the use of laboratory models for porphyrias and provide new insights into the treatment of these disorders.
New rules of social media shopping: Personality differences of U.S. Gen Z versus Gen X market mavens
Authors: Goldring Deborah , Azab Carol 
Published: November 2020

AbstractThis study compares differences in market mavenism between two generations: the young adult portion of Gen Z, born from approximately 1997 through 2012, to their Gen X parents, born from 1965 through 1980, using a field study of traits, shopping habits, and social media behaviors. Building on generational cohort theory, we conducted paired comparisons across generations and in mavens versus non‐mavens. We found differences between mavens and non‐mavens related to value consciousness, marketplace interfaces, status consumption, need for uniqueness, and social outcomes decision making. Significant differences were also found between GenZs and GenXs mavens when it comes to status consumption and social outcomes decision making. We also analyzed social media engagement by product category and platform and finally, suggest managerial implications.
Chronic total occlusion percutaneous coronary intervention: The Latin American experience
Authors: Postalian Alexander , Krajcer Zvonimir 
Published: November 2020

Key Points
The role of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) remains to be clarified.
The authors describe their experience with CTO PCI in Latin America. Success and complication rates were similar to those reported in other large CTO registries.
We welcome reports such as this that assist our group efforts in determining which patients benefit the most from CTO PCI and how we can best increase success rates while minimizing complications.
Overcoming obstacles in interventional cardiology training during the COVID‐19 pandemic
Authors: Okutucu Sercan , Cilingiroglu Mehmet 
Published: November 2020

Key Points
During Covid‐19 pandemic, elective interventions have been postponed at many medical centers in the United States. This might have had significant impact on interventional cardiology training.
A significant proportion of interventional cardiology fellows think that by the end of their training they may not reach the minimum procedural requirements; and nearly half believe that the COVID‐19 pandemic will affect their interventional skills.
There is need to review current interventional cardiology program requirements and strategic solutions to supplement gaps in education and experience related to reduced interventions.
Staged CTO PCI: The investment that pays dividends
Authors: Rodriguez‐Paz Enrique , Heuser Richard 
Published: November 2020

Key Points
For those who perform CTO recanalization, initial failure does not mean the vessel cannot be opened later.
If repeat PCI is performed after subintimal plaque modification, it is best to let the vessel heal for at least 60 days before reattempting the procedure for the best results.
A second procedure in a CTO can result in high success rate (83%).
Catheter allotopia with totally implantable access port: A report of three cases and literature review
Authors: Gu Jialin , Wei Guoli , Li Lingchang , Ji Yi , Yu Jialin , Hu Canhong , Huo Jiege 
Published: November 2020

AbstractEarly detection and treatment are critical for preventing catheter allotopia in the totally implantable access ports and whenever possible, the right internal jugular vein should be selected as the first puncture point.
Advances in Metal Phthalocyanine based Carbon Composites for Electrocatalytic CO2 Reduction
Authors: Yue Zijun , Ou Caixia , Ding Nengwen , Tao Lihong , Zhao Jianjun , Chen Jun 
Published: November 2020

AbstractFossil energy can bring great convenience to human beings, but the carbon dioxide released at the same time can produce Greenhouse Effect, resulting in the rise of Earth's temperature, which has a great impact on the environment. Therefore, how to efficiently catalyze the reduction of carbon dioxide is a hot issue to be solved. Metal phthalocyanines exhibit superior electrochemical catalytic performance due to their large conjugated structure, while carbon nanotubes and graphene, as nanoscale materials, have extremely large surface area and excellent electrochemical performance. The combination of carbon nanotubes and graphene with metal phthalocyanine can greatly improve the electrocatalytic performance of the composites. Herein, in this review, the mechanism of catalytic reduction of carbon dioxide (CO2) by metal phthalocyanine based composites and its research progress are reviewed, the current problems in the field of electrocatalysis of phthalocyanine based composites with the future prospects are presented. We hope this review will help to stimulate further development of phthalocyanine based composites with high performance CO2 catalytic reduction.