bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra-fast Prediction of Somatic Structural Variations by Reduced Read Mapping via Pan-Genomek-mer Sets
Authors: Choi Min-Hak , Sohn Jang-il , Yi Dohun , Menon A Vipin , Kim Yeon Jeong , Kyung Sungkyu , Shin Seung-Ho , Na Byunggook , Joung Je-Gun , Yoon Sungro , Koh Youngil , Baek Daehyun , Kim Tae-Min , Nam Jin-Wu 
Published: October 2020

ABSTRACTGenome rearrangements often result in copy number alterations of cancer-related genes and cause the formation of cancer-related fusion genes. Current structural variation (SV) callers, however, still produce massive numbers of false positives (FPs) and require high computational costs. Here, we introduce an ultra-fast and high-performing somatic SV detector, called ETCHING, that significantly reduces the mapping cost by filtering reads matched to pan-genome and normalk-mer sets. To reduce the number of FPs, ETCHING takes advantage of a Random Forest classifier that utilizes six breakend-related features. We systematically benchmarked ETCHING with other SV callers on reference SV materials, validated SV biomarkers, tumor and matched-normal whole genomes, and tumor-only targeted sequencing datasets. For all datasets, our SV caller was much faster (≥15X) than other tools without compromising performance or memory use. Our approach would provide not only the fastest method for largescale genome projects but also an accurate clinically practical means for real-time precision medicine.
Structural basis of rotavirus RNA chaperone displacement and RNA annealing
Authors: Bravo Jack P. K. , Bartnik Kira , Venditti Luca , Gail Emma H. , Davidovich Chen , Lamb Don C , Tuma Roman , Calabrese Antonio N. , Borodavka Alexander 
Published: October 2020

AbstractRotavirus genomes are distributed between eleven distinct RNA molecules, all of which must be selectively co-packaged during virus assembly. This likely occurs through sequence-specific RNA interactions facilitated by the RNA chaperone NSP2. Here, we report that NSP2 auto-regulates its chaperone activity through its C-terminal region (CTR) that promotes RNA-RNA interactions by limiting its helix-unwinding activity. Unexpectedly, structural proteomics data revealed that the CTR does not directly interact with RNA, whilst accelerating RNA release from NSP2. Cryo-electron microscopy reconstructions of an NSP2-RNA complex reveal a highly conserved acidic patch poised towards RNA. Virus replication was abrogated by charge-disrupting mutations within the acidic patch but completely restored by charge-preserving mutations. Mechanistic similarities between NSP2 and the unrelated bacterial RNA chaperone Hfq suggest that accelerating RNA dissociation whilst promoting inter-molecular RNA interactions may be a widespread strategy of RNA chaperone recycling.
Implementation of a crossed-slit system for fast alignment of sealed polycapillary X-ray optics
Authors: Zymaková Anna , Khakurel Krishna , Picchiotti Alessandra , Błachucki Wojciech , Szlachetko Jakub , Rebarz Mateusz , Uhlig Jens , Andreasson Jakob 
Published: October 2020

A new modification of a table-top laser-driven water-jet plasma X-ray source has been successfully implemented and commissioned at the Extreme Light Infrastructure (ELI) Beamlines user facility. In order to preserve the broadband nature of the source for spectroscopic experiments, a polycapillary lens was initially chosen as the focusing element. Generally, polycapillary X-ray optics have a narrow photon acceptance angle and small field of view, making alignment complicated and time-consuming. This contribution demonstrates a straightforward, reliable and reproducible procedure for aligning polycapillary focusing optics with broadband X-rays. The method involves a pre-alignment step where two X-ray slits are mounted orthogonally on opposite sides of a 3D-printed cylindrical polycapillary holder. This helps to precisely determine the optical axis of the X-ray beam. Subsequent mounting of the polycapillary in the pre-aligned holder with the slits removed allowed for immediate transmission of the X-ray photons through the optics and has provided a good starting point for fine alignment.
Accounting for control of Italian culture in the Fascist Ethical State: the Alla Scala Opera House
Authors: Bigoni Michele , Funnell Warwick , Deidda Gagliardo Enrico , Pierotti Mariarita 
Published: October 2020

PurposeThe study focusses on the complex interaction between ideological beliefs, culture and accounting by identifying during Benito Mussolini's time in power the contributions of accounting to the Italian Fascist repertoire of power in the cultural domain. It emphasises the importance of accounting in making the Alla Scala Opera House in Milan a vital institution in the creation of a Fascist national culture and identity which was meant to define the Fascist “Ethical State”.Design/methodology/approachThe study adopts the Foucauldian concept of discourse in analysing the accounting practices of the Alla Scala Opera House.FindingsFinancial statements and related commentaries prepared by the Alla Scala Opera House were not primarily for ensuring good management and the minimisation of public funding in contrast to the practices and expectations of accounting in liberal States. Instead, the dominant Fascist discourse shaped the content and use of accounting and ensured that accounting practices could be a means to construct the Opera House as a “moral individual” that was to serve wider national interests consistent with the priorities of the Fascist Ethical State.Research limitations/implicationsThe study identifies how accounting can be mobilised for ideological purposes in different ways which are not limited to supporting discourses inspired by logics of efficiency and profit. The paper also draws attention to the contributions of accounting discourses in shaping the identity of an organisation consistent with the priorities of those who hold the supreme authority in a society.Social implicationsThe analysis of how the Fascist State sought to reinforce its power by making cultural institutions a critical part of this process provides the means to understand and unmask the taken-for-granted way in which discourses are created to promote power relations and related interests such as in the rise of far-right movements, most especially in weaker and more vulnerable countries at present.Originality/valueUnlike most of the work on the relationship between culture and accounting which has emphasised liberal States, this study considers a non-liberal State and documents a use of accounting in the cultural domain which was not limited to promoting efficiency consistent with the priorities now recognised more recently of the New Public Management. It presents a micro-perspective on accounting as an ideological discourse by investigating the role of accounting in the exploitation of a cultural institution for political purposes.
“This wine is dead!”: unravelling the effect of word-of-mouth and its moderators in price-based wine quality perceptions
Authors: Aqueveque Claudio , Rodrigo Pablo 
Published: October 2020

PurposeThe purpose is to evaluate the effect of positive and negative traditional word-of-mouth (PWOM and NWOM) on price-based quality perceptions of middle-range wine (price comprised between US$4 and US$12), considering the moderator role of type of relationship between source and receiver –in terms of the strength-of-tie – and the wine expertise of the source.Design/methodology/approachA between-subjects experimental design was employed to test the hypotheses. The dependent variable, perceived quality, was analysed using analysis of variance (ANOVA) and independent samples t-tests.Findings(1) WOM significantly affects price-based wine quality perceptions only when the source is perceived as expert, and independently on the type of relationship between source and receiver. (2) WOM has no “additive effect” on price-based quality perceptions for all but one condition (PWOM about high-priced wine from a close and expert source). (3) WOM results more useful than price to assess quality mainly in “contradictory” situations.Research limitations/implicationsThe main limitation is related to the fact that is an experiment, specifically the manipulation of strength-of-tie and source expertise. Although manipulation checks show good results for the procedure, future research should try to design better ways to manipulate these variables, or different procedures to capture similar data.Practical implicationsManagerial efforts aimed to the encouragement of PWOM will be more efficient in markets with a high proportion of experts. Also, the marketing strategy of stimulating PWOM would be more effective for wines in the low-price category.Originality/valueThis study contributes to understand the impact of WOM on wine quality perceptions by examining if WOM affects priors price-based quality perceptions. In particular, we determine if price-based quality perceptions are able to be modified by PWOM and NWOM, a “competing” approach that is novel within the wine literature in which price is usually the most used cue to elaborate quality perceptions.
Exploring the relationship between corporate entrepreneurship and firm performance: the mediating effect of strategic entrepreneurship
Authors: Ziyae Babak , Sadeghi Hossein 
Published: October 2020

PurposeStrategic entrepreneurship rejuvenates firms to achieve a competitive advantage in current markets. It is effective in forming corporate entrepreneurship and involves the simultaneous opportunity-seeking and advantage-seeking behaviors of firms. The aim of this paper is to investigate the mediating effect of strategic entrepreneurship in the relationship between corporate entrepreneurship and firm performance through the resource-based view.Design/methodology/approachAdopting a quantitative research method and structural equation modeling technique, structural models were developed to test the research hypotheses. To this end, a questionnaire survey was conducted among 103 financial technology companies in Iran.FindingsThe results support the proposed hypotheses. The findings indicate that corporate entrepreneurship and strategic entrepreneurship are positively related to firm performance. They also reveal the mediating effect of strategic entrepreneurship in the relationship between corporate entrepreneurship and firm performance. In the developing context of Iran, financial technology companies are more likely to employ corporate entrepreneurship and strategic entrepreneurship to achieve firm performance.Originality/valueThe current study contributes to the literature on strategic entrepreneurship by employing a resource-based view and exploring the relationship between firm capabilities (i.e. strategic entrepreneurship) and firm performance. Applying a resource-based view leads to a better understanding of strategic entrepreneurship. Finally, this study singles out and discusses the various features that characterize the implementation of strategic entrepreneurship by Iranian financial technology companies to reach a competitive advantage.
Price decline, land rental markets and grain production in the North China Plain
Authors: Wang Qian , Li Fan , Yu Jin , Fleskens Luuk , Ritsema Coen J. 
Published: October 2020

PurposeThis study examines the heterogeneous correlations between rural farmers' land renting behavior and their grain production when they experienced a significant price decline.Design/methodology/approachWe used well-timed panel data obtained from a two-round survey held in 2013 and 2017 among 621 households in the North China Plain. The empirical analyses were conducted by using the pooled ordinary least squares (OLS) and fixed effects models.FindingsRural tenants were having heterogeneous responses in land renting behavior and agricultural production when there was a price decline. A group of optimistic tenants (as professional farmers) were more likely to enlarge the farm scale for grain production through land rental markets but decrease variable investment levels (and subsequently decreased productivity) to cope with price decline. In contrast, nonprofessional farmers (the other rural tenants) were rather pessimistic about market performance, and they significantly decreased their grain production area to cope the price decline, but there was no decrease in grain productivity through reducing variable inputs.Originality/valueThis study contributes to the extant literature on the relationship between farmers' land renting-in behavior and agricultural production. By dividing the tenants into professional and nonprofessional farmers, we argue that there is a significant heterogeneous correlation between rural tenants' land renting behavior and grain production when farmers experience a price decline.
TrCSVM: a novel approach for the classification of melanoma skin cancer using transfer learning
Authors: Singh Lokesh , Janghel Rekh Ram , Sahu Satya Prakash 
Published: October 2020

PurposeThe study aims to cope with the problems confronted in the skin lesion datasets with less training data toward the classification of melanoma. The vital, challenging issue is the insufficiency of training data that occurred while classifying the lesions as melanoma and non-melanoma.Design/methodology/approachIn this work, a transfer learning (TL) framework Transfer Constituent Support Vector Machine (TrCSVM) is designed for melanoma classification based on feature-based domain adaptation (FBDA) leveraging the support vector machine (SVM) and Transfer AdaBoost (TrAdaBoost). The working of the framework is twofold: at first, SVM is utilized for domain adaptation for learning much transferrable representation between source and target domain. In the first phase, for homogeneous domain adaptation, it augments features by transforming the data from source and target (different but related) domains in a shared-subspace. In the second phase, for heterogeneous domain adaptation, it leverages knowledge by augmenting features from source to target (different and not related) domains to a shared-subspace. Second, TrAdaBoost is utilized to adjust the weights of wrongly classified data in the newly generated source and target datasets.FindingsThe experimental results empirically prove the superiority of TrCSVM than the state-of-the-art TL methods on less-sized datasets with an accuracy of 98.82%.Originality/valueExperiments are conducted on six skin lesion datasets and performance is compared based on accuracy, precision, sensitivity, and specificity. The effectiveness of TrCSVM is evaluated on ten other datasets towards testing its generalizing behavior. Its performance is also compared with two existing TL frameworks (TrResampling, TrAdaBoost) for the classification of melanoma.
Numerical analysis of the flow and heat transfer characteristics in serpentine microchannel with variable bend amplitude
Authors: Zhang Hui , Liu Xianfei 
Published: October 2020

PurposeThis study aims to propose the increase of heat dissipation requirements of modern electronic equipment and the fast development of micro-scale manufacturing technologies. The heat transfer mechanism is studied in-depth, especially for its pattern of secondary flow caused by the repeated inversion of centrifugal force. Effects ofηon the frictional pressure drop and average Nusselt number are studied and the performance of such microchannel heat sink with various bend amplitudes is comprehensively evaluated. These results can provide important insight into the optimal design of this novel design configuration for microelectronics cooling.Design/methodology/approachA three-dimensional model based on the finite volume approach and SIMPLEC algorithm is performed to test an innovative serpentine microchannel, which behaves differently from conventional serpentine microchannel due to the significant effect of centrifugal force inversion.FindingsThe effect of centrifugal force significantly influences the flow and thermal fields which are responsible for the enhancement in heat transfer coefficient. The number, size and intensity of vortices increase with increasing Re, and the vortices are reformed at every change of the geometry in a periodic fashion. The serpentine microchannel studies more effectively at larger bend amplitude. Pressure fluctuations and temperature variation are greater with increasing bend amplitude.Practical implicationsSeveral techniques have been developed to augment single-phase convective heat transfer in channels. One technique is to use a serpentine channel that enhances the heat transfer due to flow mixing and periodic interruption of thermal boundary layers. This technique has been applied to micro-heat exchangers, thermal regenerators and mini/microreactors.Social implicationsThe optimal design of this novel design configuration for microelectronics cooling can be attained. It will become an effective cooling technology for solving the increasing of heat dissipation requirements of modern electronic equipment.Originality/valueThe flow and heat transfer characteristics are first presented for the circular serpentine microchannel made up of alternate U-bends without interposed straight segments. The present study first examines the effect of such centrifugal force inversion on velocity contour, pressure distribution and temperature distribution. The patterns of secondary flow along the flow passage caused by the repeated inversion of centrifugal force are further studied in depth. The effect of bend amplitude on the flow and heat transfer is explored and the performance of such microchannel heat sink has been comprehensively evaluated.
Rise of the machines: towards a conceptual service-robot research framework for the hospitality and tourism industry
Authors: McCartney Glenn , McCartney Andrew 
Published: October 2020

PurposeThis study aims to introduce a conceptual framework for service robot (SR) acceptance by customers, employees and policymakers – a framework to help determine corporate decision-making on SR workplace integration.Design/methodology/approachThis study reviews SR adoption literature within the tourism and hospitality industry. These SRs may have some level of artificial intelligence capability and possibly anthropomorphic (e.g. humanoid) or zoomorphic (e.g. animal-like) features, contingent on task and design choices. The study then identifies factors that potentially influence employee and consumer acceptance and experiences of SR, as well as policy and compliance factors and all elements of the corporate decision-making process concerning SR adoption in the hospitality setting.FindingsThis paper reviews the obstacles and benefits of SR adoption in the hospitality industry based on employee, consumer and public policy considerations.Research limitations/implicationsSRs are increasingly deployed within hospitality and tourism settings. Future studies should further explore the value-adding functions of SRs implemented in existing hospitality operations.Practical implicationsHospitality and tourism industry practitioners should integrate the dimensions in the conceptual framework to make fully informed decisions on SR adoption.Originality/valueTo the best of the authors’ knowledge, this is one of the first studies to provide a holistic SR adoption framework offering theoretical and practical implications for ongoing SR research and implementation.
Cyberchondria: a systematic review
Authors: Zheng Han , Sin Sei-Ching Joanna , Kim Hye Kyung , Theng Yin-Leng 
Published: October 2020

PurposeCyberchondria describes excessive or repeated online health-related information seeking associated with an increased level of health anxiety. Given the nascent nature of the concept of cyberchondria, this systematic review attempts to summarize the current landscape of cyberchondria research.Design/methodology/approachBased on a comprehensive search and systematic filtering process, 40 articles were included in the final sample.FindingsCharacteristics of these articles, measures of cyberchondria and factors related to cyberchondria were reported. This review found that the measures of cyberchondria are still in the developmental stages and thus require further validation in future studies. In addition, while studies have examined various factors associated with cyberchondria, the detailed processes involved in the development of cyberchondria require further conceptualization.Originality/valueThe contributions of this review are threefold: first, it presented a comprehensive overview of studies on cyberchondria by addressing their key characteristics such as country of study, sample size and research method. Second, this review analyzed major assessment tools of cyberchondria to offer useful guidance on future investigations on cyberchondria. Third, it identified important antecedents and consequences of cyberchondria in previous research, which contributes to theoretical understanding of how cyberchondria develops.
Grounded theory and the PhD – notes for novice researchers
Authors: Thurlow Lisa 
Published: October 2020

PurposeThis paper aims to consider the realities and problematics of applying a grounded theory (GT) approach to research, as a novice, within a mixed methods study during post graduate research. Its intention is to provide the novice user with a framework of considerations and greater awareness of the issues that GT can expose during research activity.Design/methodology/approachUsing empirical evidence and a comparative approach, the paper compares the efficacy of both the classic Glaserian and Straussian models. It observes the effects of a positivist academic environment upon the choice of approach and its application. This study was specific to design education; however, its reliance upon a social science epistemology results in findings beneficial to research novices across broader disciplines.FindingsGT presents the novice researcher with several potential pitfalls. Most problematic were the immutable, positivist institutional requirements, researchera prioriknowledge, the reliance upon literature for the research proposal and structure of the proposal itself. These include suspension of the notion that the purist use of either model can be applied in the current academic environment, the need for a close relationship with the data and toleration of a non-linear process with unexpected results.Originality/valueThe practicalities of GT research are often reflected upon by the academy, but use by novice researchers is little considered. The findings from this study provide a novel set of guidelines for use by those embarking on GT research and particularly where the requirements of formal education may cause a conflict.