bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scaled-up Processes for the Preparation of Enhanced Antibacterial ZnO-Menthol, ZnO-Chitosan, and ZnO-Triclosan Flake/Spine-like Nanocomposites, and their Biocompatibility and Toxicity Studies
Authors: Rajapakshe R.B.S.D. , Thennakoon C.A. , Nishananthy N. , Niyangoda Sayuri S. , Thennakoon Siddartha , Rajapakse Rajapakse Mudiyanselage Gamini , Rajapakse Sanath 
Published: December 2024

Introduction:
Nanomaterials, especially their biocompatibilities and toxicities, have
not been studied and their integration in real applications is still limited.

Method:
This paper addresses this gap by focusing on the development of antibacterial nanomaterials
by combining flake/spinal ZnO nanostructures with organic antibacterial agents (menthol,
chitosan, and triclosan). We systematically study their biocompatibility and toxicity, intending
to apply them practically on fabric surfaces.

Result:
Based on the known photocatalytic and antibacterial properties of ZnO, our hypothesis
suggests that the unique flake/spine ZnO nanostructures can further improve the antibacterial
efficacy through induced mechanistic approaches. The synergistic effect achieved by combining
ZnO with menthol, chitosan, and triclosan improves the overall bactericidal ability. XRD, XRF,
FTIR, SEM, and UV-visible spectroscopy are used to characterize the nanocomposites. The
antibacterial properties of the modified fabrics are tested using standard spread plate techniques.
Biocompatibility and toxicity studies using a mouse model provide a comprehensive picture of
the safety profile.

Conclusion:
This work advances the understanding of antibacterial nanomaterials, and paves the
way for their wider manufacturing and practical use in textiles, meeting the industrial needs of
antimicrobial clothing and wound dressings.
A Comprehensive Review of Fear of Eating Behaviour in Individuals with Diabetes: Exploring Therapeutic Interventions for Diabulimia
Authors: Wal Ankita , Sahu Pankaj Kumar , Wal Pranay , Sahu Kaminee , Bhise Manish Ramesh , Lodhi Devendra Singh 
Published: December 2024

Objective:
This review aims to comprehensively analyse the fear of eating behaviour in
individuals with diabetes, known as diabulimia or ED-DMT1. The emotional and psychological
factors contributing to disordered eating behaviours, their impact on diabetes management, and potential
consequences on physical health are explored. Various therapeutic interventions, including
cognitive-behavioural therapy and psychological support, the role of nutrition education, individualized
treatment plans support groups in managing fear of eating behaviour in diabetes are examined
and discussed.

Methods:
A comprehensive literature search was conducted to identify relevant studies, articles,
and guidelines related to fear of eating behaviour in diabetes. The search included databases such
as PubMed and Google Scholar using appropriate keywords.

Results:
The review highlights the emotional and psychological factors that contribute to the fear
of eating behaviour in diabetes, including body image concerns, fear of weight gain, and disordered
eating patterns. These behaviours can significantly impact diabetes management, leading to
poor glycaemic control, increased risk of complications, and reduced overall well-being. Various
therapeutic interventions, such as cognitive-behavioural therapy and mindfulness-based interventions,
have shown promise in addressing the fear of eating behaviour.

Conclusion:
A multidisciplinary strategy combining healthcare specialists specializing in diabetes
management, mental health, and nutrition is required for effective therapy of fear of eating behaviour
in diabetes. Cognitive-behavioral therapy and mindfulness-based therapies, as well as psychological
support, have shown potential in reducing the fear of eating habits. This analysis gives
significant information for healthcare providers to help patients with diabetes who are afraid of
eating and urges additional research on the topic.
Repurposing of Empagliflozin as Cardioprotective Drug: An in-silico Approach
Authors: Yadav Jyoti , Ahsan Farogh , Panda Prabhudatta , Mahmood Tarique , Bano Shahzadi , Shamim Arshiya , Mishra Pooja 
Published: December 2024

Background:
Drug repurposing involves investigating new indications or uses for
drugs that have already been approved for clinical use. Empagliflozin is a C-glycosyl compound
characterized by the presence of a beta-glucosyl residue. It functions as a sodium-glucose co-transporter
2 inhibitor and is utilized to enhance glycemic control in adults diagnosed with type 2 diabetes
mellitus. Additionally, it is indicated for the reduction of cardiovascular mortality risk in
adult patients who have both type 2 diabetes mellitus and pre-existing cardiovascular disease.

Objective:
The study's objective revolves around exploring the repurposing potential of a novel
SGLT2 inhibitor acting as an antidiabetic drug named Empagliflozin through computational methods,
with a specific focus on its interaction with cardioprotective key target proteins.

Methods:
The study was performed by docking the empagliflozin with different target proteins (NHE1-
CHP1, BIRC5, GLUT1, and XIAP) by using Autodock, and different values were recorded.
The docked files were analysed by the BIOVIA Discovery Studio Visualizer. The in silico analysis
conducted in this study examines the binding free energy values of Empagliflozin with key target
proteins.

Results:
Results revealed that NHE1-CHP1 exhibits the lowest binding free energy, followed by
BIRC5, GLUT1, and XIAP, with the highest value. This descending order of binding energies
suggests varying degrees of effectiveness in binding molecules, with lower energies indicative of
more potent biological activity. The analysis underscores the importance of intermolecular interactions,
particularly hydrogen bond formations facilitated by oxygen, nitrogen, and carbonyl groups
in compound structures. Notably, NHE1-CHP1 demonstrates superior binding interactions with
Empagliflozin compared to the other target proteins, highlighting its potential as a cardioprotective
agent.

Conclusion:
These findings offer valuable insights into the therapeutic possibilities of Empagliflozin
in cardioprotection, indicating promising avenues for further research and development in
this domain.
Sample Size Requirements for Popular Classification Algorithms in Tabular Clinical Data: Empirical Study
Authors: Silvey Scott , Liu Jinze 
Published: December 2024

Background
The performance of a classification algorithm eventually reaches a point of diminishing returns, where the additional sample added does not improve the results. Thus, there is a need to determine an optimal sample size that maximizes performance while accounting for computational burden or budgetary concerns.

Objective
This study aimed to determine optimal sample sizes and the relationships between sample size and dataset-level characteristics over a variety of binary classification algorithms.

Methods
A total of 16 large open-source datasets were collected, each containing a binary clinical outcome. Furthermore, 4 machine learning algorithms were assessed: XGBoost (XGB), random forest (RF), logistic regression (LR), and neural networks (NNs). For each dataset, the cross-validated area under the curve (AUC) was calculated at increasing sample sizes, and learning curves were fit. Sample sizes needed to reach the observed full–dataset AUC minus 2 points (0.02) were calculated from the fitted learning curves and compared across the datasets and algorithms. Dataset–level characteristics, minority class proportion, full–dataset AUC, number of features, type of features, and degree of nonlinearity were examined. Negative binomial regression models were used to quantify relationships between these characteristics and expected sample sizes within each algorithm. A total of 4 multivariable models were constructed, which selected the best-fitting combination of dataset–level characteristics.

Results
Among the 16 datasets (full-dataset sample sizes ranging from 70,000-1,000,000), median sample sizes were 9960 (XGB), 3404 (RF), 696 (LR), and 12,298 (NN) to reach AUC stability. For all 4 algorithms, more balanced classes (multiplier: 0.93-0.96 for a 1% increase in minority class proportion) were associated with decreased sample size. Other characteristics varied in importance across algorithms—in general, more features, weaker features, and more complex relationships between the predictors and the response increased expected sample sizes. In multivariable analysis, the top selected predictors were minority class proportion among all 4 algorithms assessed, full–dataset AUC (XGB, RF, and NN), and dataset nonlinearity (XGB, RF, and NN). For LR, the top predictors were minority class proportion, percentage of strong linear features, and number of features. Final multivariable sample size models had high goodness-of-fit, with dataset–level predictors explaining a majority (66.5%-84.5%) of the total deviance in the data among all 4 models.

Conclusions
The sample sizes needed to reach AUC stability among 4 popular classification algorithms vary by dataset and method and are associated with dataset–level characteristics that can be influenced or estimated before the start of a research study.
Effects of slow internet on academic library staff productivity and job satisfaction
Authors: Durodolu Oluwole O. , Iroaganachi Mercy A , Otunla Josephine N 
Published: December 2024

Introduction. This paper investigated the effects of slow internet on academic library staff productivity and job satisfaction of academic library staff using the University of Ibadan library as a case in focus.
Data Collection Methods. The study employed a qualitative research method, guided by a phenomenological research paradigm, using Focus Group discussions for data collection. The responses were presented and discussed objectively.
Data Analysis. NVivo software was used for qualitative data analysis to enhance the depth of qualitative research by providing data management technique and facilitate complex analyses, and support robust reporting.
Results and Discussion. Findings of the study revealed that slow internet may have serious consequences on library staff, their operations, and productivity including; decreased output, staff dissatisfaction, and hampered user services etcetera. The study recommends that universities and library management invest in faster, more reliable internet, implement hybrid systems to provide alternative resources during technological limitations, ensure librarians are adaptable in managing slow internet challenges, and encourage librarians to maintain a positive mindset to avoid frustration and job dissatisfaction.
Conclusion. This research addresses a gap in the literature by examining how internet speed impacts library staff productivity and satisfaction, providing insights for enhancing library services and staff well-being amidst technological challenges.
Kontribusi Taman Bacaan Masyarakat “Pondok Baca Puspita” di Kabupaten Wonosobo sebagai fasilitator belajar anak usia sekolah dasar
Authors: Rahmah Tadzqiya Aulia , Ganggi Roro Isyawati Permata 
Published: December 2024

Introduction. The people of Candi Hamlet, Wonosobo, are limited in accessing local libraries due to several factors. TBM “Pondok Baca Puspita” eventually became the strong foundation of the community in fulfilling information needs. This study discusses the contribution of TBM “Pondok Baca Puspita” as a means of learning for school children.
Data Collection Methods. This is a descriptive qualitative research with the data collection techniques such as interviews, observation, literature study, and document analysis.
Data Analysis. We used the interactive analysis model by Milles and Huberman's data analysis method. This involves data reduction, data presentation, and conclusion drawing.
Results and Discussion. We identified several challenges in learning activities faced by elementary school-age children in Candi Hamlet, Wonosobo. They were low motivation to learn, economic limitations, and limited means of technology-based learning fulfillment. The contribution of TBM in providing learning facilities is shown in the Sedekah Ilmu Program, as a learning concept, which is a form of non-physical contribution. The provision of mobile phone was to assist in terms of physical contribution. TBM “Pondok Baca Puspita” collaborate with several parties to improve the services.
Conclusion. TBM “Pondok Baca Puspita” contributes physically and non-physically in providing learning facilities for elementary school children in Candi Hamlet, Wonosobo.
Private Equity Fund Reporting Quality, External Monitors, and Third-Party Service Providers
Authors: Easton Peter D. , Larocque Stephannie A. , Mason Paul , Utke Steven 
Published: December 2024

ABSTRACT
We describe variation in the reporting quality (i.e., accuracy and bias of reported net asset values (NAVs)) of private equity (PE) funds across types of external monitors (investors and auditors) and third-party service providers (valuation specialists, marketers, and administrators). In contrast to public markets, we find only limited evidence that reporting quality varies with the composition and types of investors in PE funds. We observe, however, that reporting quality varies with auditor involvement and the use of third-party service providers; these associations often differ across buyout (BO) and venture capital (VC) funds and from those observed in public markets. Our evidence is important to investors and regulators, especially now that PE supersedes public markets as the main vehicle to raise capital and as regulators increase their focus on private markets.
Data Availability: Data used in this study are available from public sources listed in the paper.
JEL Classifications: G1; G14; G30; M4; M41.
Arterial liver supply in aspect of right lobe living donor liver transplantation: anatomical variants and reconstruction
Authors: Voskanyan S. E. , Kolyshev I. Yu. , Bashkov A. N. , Artemyev A. I. , Rudakov V. S. , Shabalin M. V. , Popov M. V. , Sushkov A. I. , Vohmyanin G. V. 
Published: December 2024

Background. A safe removal of the liver right lobe and restoration of arterial blood supply to the liver graft is possible only with a full understanding of the anatomy of the hepatic artery in a donor.Objective. To describe new and extend contemporary data on anatomical variations of the arterial blood flow in a donor of the right liver lobe.Material and methods. From 2009 to 2021, 306 living donor liver transplantations were performed in the State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The vascular anatomy of 518 potential donors was analyzed. Hepatic artery anatomical variants of a right lobe graft were assessed.Results. Eleven types of right lobe arterial supply and 7 subtypes of the arterial anatomy of liver segment 4 were identified. The case rates of types and subtypes where reconstruction could be performed were following: type A, subtypes 1, 2, 3, 4, 5 (57.5%, 26.1%, 5.5%, 1.9%, 0.3%, respectively); type B, subtypes 1, 4, 5 (0.3% each); type С, subtypes 1, 2 (2.9%, 1.3%, respectively); type D, subtypes 1, 3 (0.3% each); type Е subtype 1 (0.6%), types F-J subtype 1 (0.3% each). Liver right lobe harvesting and arterial reconstructions were fully performed in all types and subtypes excluding anatomical type K, subtype 7. Arterial postoperative complications (11 cases) were detected in 3.5% observed cases of 306 transplants and in 5.9% of all patients with complications (184). Mortality rate due to arterial complications was 1.9% (6 cases).Conclusion. The existing classification of right liver graft hepatic artery anatomy was updated and detailed regarding the applicability in right lobe liver transplant. The arterial anatomy of right lobe liver graft shows great variability and complexity for systematization and thus may need further studies.
The debut of benign recurrent intrahepatic cholestasis in acute hepatitis A
Authors: Kokina K. Yu. , Malinovskaya Yu. O. , Sumtsova O. V. , Grigorevskaya A. O. , Moysyuk Ya. G. 
Published: December 2024

Background. Benign recurrent intrahepatic cholestasis is a rare inherited disorder characterized by recurrent episodes of severe hyperbilirubinemia and pruritus that resolve spontaneously. However, attacks of cholestasis may persist for several months and in some cases be associated with frequent recurrences, which may be grounds for liver transplantation.Objective. To present a clinical case of debut benign recurrent intrahepatic cholestasis following acute hepatitis A.Results. A 30-year-old patient was admitted at the Liver Transplantation Center of Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirskiy for a prolonged episode of intrahepatic cholestasis with severe coagulopathy after acute hepatitis A. Total bilirubin was elevated up to 835 µmol/L and INR was 3.6. The manifestations of vitamin K-associated coagulopathy were controlled after the first dose of parenteral menadione sodium bisulfite. Glucocorticosteroids, ursodeoxycholic acid and plasmapheresis turned ineffective in the treatment of hyperbilirubinemia. Due to long-persisting cholestasis resistant to conservative therapy, the patient was considered for inclusion to the liver transplant waiting list. However, spontaneous resolution of the cholestatic episode was achieved at 5 months after the onset of manifestations. Benign recurrent intrahepatic cholestasis type 2 was diagnosed on the basis of the specific clinical signs, laboratory blood tests and genetic testing.Conclusion. The present Case Report shows a long-lasting episode of cholestasis with severe coagulopathy in acute hepatitis A in a patient with benign recurrent intrahepatic cholestasis with subsequent spontaneous resolution of the clinical symptoms at 5 months after their manifestation onset. Therefore, the differential diagnosis of benign recurrent intrahepatic cholestasis should be considered prior to liver transplantation in patients with intrahepatic cholestasis.
The experience of bilateral lung retransplantation after prolonged extracorporeal oxygenation
Authors: Tarabrin E. A. , Khubutiya M. Sh. , Guseva A. S. , Ermakova E. A. , Pervakova E. I. , Zhuravel S. V. , Gasanov A. M. , Kotandzhyan V. G. , Karchevskaya N. A. , Kallagov T. E. , Ibavov I. U. , Kevorkova M. S. , Berikkhanov Z. G. , Ivanova M. Yu. 
Published: December 2024

Background. Transplantation is the only effective method of helping patients with irreversible damage of the lung function when the possibilities of other treatment methods have been exhausted. At the same time, a chronic graft rejection is the main cause of the loss of the donor organ function in the long-term period, developing in more than 50% of patients within 5 years after surgery. Given irreversible lung damage with loss of lung functions, the only effective treatment method for this patient population is retransplantation, which is associated with high risks of complications and a long rehabilitation of the patient in the postoperative period.Objective. Demonstration of the first Russian experience of bilateral lung retransplantation in a patient after a longterm extracorporeal oxygenation.Results. The article presents the description of the first experience of bilateral lung retransplantation in Russia performed in a patient with a chronic rejection 4.5 years after the primary transplantation performed for end-stage lung lesions in non-langerhans cell histiocytosis. In the 96-day period of waiting for a donor organ, the patient's gas-exchange lung function was compensated by using veno-venous extracorporeal membrane oxygenation.Conclusions. Retransplantation is an effective method of treatment for patients with irreversibly damaged lung function, but still remains an operation associated with high risks of complications and unfavorable outcome.
Treatment of splenic artery aneurysms of patients with cirrhosis in the Waiting list
Authors: Bagateliya Z. A. , Drozdov P. A. , Astapovich S. A. , Lidzhieva E. A. , Alieva F. F. , Shabunin A. V. 
Published: December 2024

Objective. The aim of our work was to evaluate the immediate and remote results of ligation of splenic artery aneurysm in orthotopic liver transplantation in patients with decompensated liver cirrhosis.Material and methods. From June 2018 to May 2024, 232 liver transplants from a posthumous donor were performed at the Surgical Clinic of the Moscow Multidisciplinary Scientific and Clinical Center n.a. S.P. Botkin. In 4 patients (1.7%), the presence of aneurysmal dilatation of the splenic artery was revealed at the preoperative stage. During orthotopic liver transplantation, patients underwent ligation of the splenic artery proximal and distal to the aneurysms.Results. Mean time for the isolation and ligation of the splenic artery aneurysm was 18.4±3.3 minutes. In no case was there any damage or bleeding from either the branches or the aneurysm of the splenic artery; and there was no damage to the spleen. No adverse events related to the splenic artery aneurysm ligation were recorded in either early or late postoperative periods. In all cases, the control examination did not reveal any ischemic changes in the splenic parenchyma.Conclusion. Ligation of the splenic artery aneurysm during orthotopic liver transplantation is a safe, effective and necessary surgical intervention that can improve long-term results by reducing the risk of death from aneurysm rupture in the postoperative period.
Non-invasive predictors of the first episode of bleeding from esophageal varices in patients with liver cirrhosis awaiting transplantation
Authors: Korobka V. L. , Khoronko Yu. V. , Pasechnikov V. D. , Korobka R. V. , Malevanny M. V. , Pak E. S. , Pasechnikov D. V. 
Published: December 2024

Background. To date, various non-invasive techniques or tests have been proposed that can identify a high risk of bleeding from esophageal varices. Despite a significant number of studies revealing the presence of venous varices as a likely factor for the development of bleeding due to their rupture, data on predictors of the first episode of bleeding are few and often contradictory.Objective. To determine non-invasive independent predictors of the first episode of bleeding in patients waiting for liver transplantation.Material and methods. A comparative retrospective study was conducted in 729 patients with decompensated cirrhosis who were on the waiting list for liver transplantation. We analyzed demographic, clinical and laboratory parameters, MELD-Na, Child-Turcotte-Pugh scores, FIB-4 Index, APRI, AST/ALT ratio; we determined the liver stiffness, spleen diameter, studied the liver stiffness-spleen diameter to platelet ratio risk score (LSPS model), platelet count/spleen diameter ratio in the groups of patients with the first episode of bleeding (n=334) and without it (n=395). The accumulated risks in the compared groups were assessed using a model of proportional hazards (Cox regression) in univariate and multivariate analysis.Results. During 48 months of follow-up from the time of patient placement on the liver transplant waiting list, primary bleeding events developed in 45.8%. The risk of developing the first episode of bleeding progressively increased with LSPS >3.5 and reached maximum values in patients awaiting liver transplantation within 48 months of inclusion in the waiting list, while with LSPS <3.5 the risk was minimal.Conclusion. Independent non-invasive predictors of the first episode of bleeding are a high level of AST, a high fibrosis index (FIB-4), a decrease in the ratio of platelet count/spleen diameter and a high LSPS value. Their application in clinical practice will improve the results of dispensary and screening examinations of patients with portal hypertension.