bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical temperature sensing and luminescent switching properties in Pr/Er‐doped (K0.5Na0.5)NbO3 materials
Authors: Zhu Yan , Li Xuefeng , Guo Zizhong , Sun Haiqin , Zhang Qiwei , Hao Xihong 
Published: January 2020

AbstractFor optical temperature sensing materials, the emission and excitation bands are extremely critical to measure the temperature by fluorescence intensity ratio (FIR) technique. Singly Ln‐doped optical temperature sensing materials exhibit very few emission bands, which greatly constraints their practical applications of FIR technique. Here, the fabricated Pr/Er co‐doped (K0.5Na0.5)NbO3 materials exhibited multi‐color (red‐green) and dual‐mode (downshifting/upconversion) luminescence properties. The temperature sensitivity can be effectively tuned by choosing different emission or excitation bands. The optimized optical temperature sensitivity reached up to 0.0094 K−1, much higher than that of most temperature sensing materials. Besides, the samples also showed excellent luminescence modulation properties based on the photochromic reaction. Under sunlight irradiation, the luminescent switching contrast (ΔRt) of the samples reached more than 60%. These results may provide a guiding role in designing and modulating optical temperature sensing properties for multifunctional materials.
Security regulations, access to capital markets, and firm performance: Evidence from China
Authors: Wang Kun , Wei Zhe , Xiao Xing , Sun Kunpeng 
Published: January 2020

AbstractThis study explores the cost of security regulations in China, where firms are required to meet a certain profitability benchmark before applying for permission to raise more equity via secondary equity offerings (SEOs). Using a difference‐in‐differences setting, we show that firms affected by the regulation (i.e., firms with high external financing demands (EFD) but profitability lower than the regulatory requirement) significantly underperform their counterparts, while unaffected firms do not. The affected firms’ performance decline increases (decreases) when the requirement of profitability is more (less) restricted. Consistently, the three‐day cumulative abnormal return (CAR) of firms with high EFD is significantly negative (positive) when the regulation is tightened (loosened). Our study provides evidence on how the cost of regulation affects companies that have growth opportunities.
The functions and targets of miR‐212 as a potential biomarker of cancer diagnosis and therapy
Authors: Chen Wenjun , Song Jing , Bian Hongjun , Yang Xia , Xie Xiaoyu , Zhu Qiang , Qin Chengyong , Qi Jianni 
Published: January 2020

AbstractCancer is a major health problem worldwide. An increasing number of researchers are studying the diagnosis, therapy and mechanisms underlying the development and progression of cancer. The study of noncoding RNA has attracted a lot of attention in recent years. It was found that frequent alterations of miRNA expression not only have various functions in cancer but also that miRNAs can act as clinical markers of diagnosis, stage and progression of cancer. MiR‐212 is an important example of miRNAs involved in cancer. According to recent studies, miR‐212 may serve as an oncogene or tumour suppressor by influencing different targets or pathways during the oncogenesis and the development and metastasis of cancer. Its deregulation may serve as a marker for the diagnosis or prognosis of cancer. In addition, it was recently reported that miR‐212 was related to the sensitivity or resistance of cancer cells to chemotherapy or radiotherapy. Here, we summarize the current understanding of miR‐212 functions in cancer by describing the relevant signalling pathways and targets. The role of miR‐212 as a biomarker and its therapeutic potential in cancer is also described. The aim of this review was to identify new methods for the diagnosis and treatment of human cancers.
Aminooxyacetic acid attenuates post‐infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice
Authors: Zhao Pei , Zhou Wenjing , Zhang Yanxia , Li Jingjing , Zhao Ye , Pan Lihua , Shen Zhenya , Chen Weiqian , Hui Jie 
Published: January 2020

AbstractExcessive activation of pro‐inflammatory M1 macrophages following acute myocardial infarction (MI) aggravates adverse cardiac remodelling and heart dysfunction. There are two break points in the tricarboxylic acid cycle of M1 macrophages, and aspartate‐arginosuccinate shunt compensates them. Aminooxyacetic acid (AOAA) is an inhibitor of aspartate aminotransferase in the aspartate‐arginosuccinate shunt. Previous studies showed that manipulating macrophage metabolism may control macrophage polarization and inflammatory response. In this study, we aimed to clarify the effects of AOAA on macrophage metabolism and polarization and heart function after MI. In vitro, AOAA inhibited lactic acid and glycolysis and enhanced ATP levels in classically activated M1 macrophages. Besides, AOAA restrained pro‐inflammatory M1 macrophages and promoted anti‐inflammatory M2 phenotype. In vivo, MI mice were treated with AOAA or saline for three consecutive days. Remarkably, AOAA administration effectively inhibited the proportion of M1 macrophages and boosted M2‐like phenotype, which subsequently attenuated infarct size as well as improved post‐MI cardiac function. Additionally, AOAA attenuated NLRP3‐Caspase1/IL‐1β activation and decreased the release of IL‐6 and TNF‐α pro‐inflammatory cytokines and reciprocally increased IL‐10 anti‐inflammatory cytokine level in both ischaemic myocardium and M1 macrophages. In conclusion, short‐term AOAA treatment significantly improves cardiac function in mice with MI by balancing macrophage polarization through modulating macrophage metabolism and inhibiting NLRP3‐Caspase1/IL‐1β pathway.
Effect of sprouting temperature on selected properties of wheat flour and direct expanded extrudates
Authors: Krapf Julia , Ding Linda , Brühan Juliane , Lorimer Luisa , Walther Goeran , Flöter Eckhard 
Published: January 2020

AbstractThe effect of the sprouting temperature on wheat sprouting and on the properties of expanded extrudates produced from sprouted wheat flour was studied. Therefore, wheat was sprouted at five different temperatures and subsequently dried, milled, and the resulting flour was used to produce extrudates using a twin‐screw extruder. In order to understand the sprouting temperature effect, the degree of sprouting (DoS) of the differently sprouted samples and characteristic properties of flour and extrudates were studied and compared. During sprouting of wheat with increasing temperature and time an increase of the α‐amylase activity, the vitamin C and reducing sugar content, and a decrease of the peak viscosity was observed. The greatest effect was found at 20°C. Furthermore, the lowering of the viscosity of the flour suspension results in a reduction of the pressure and temperature in the extruder die. The extrudates of sprouted wheat flour were found to be easier to break, had a lower density, an increased longitudinal expansion index, and an improved cold‐water solubility. A good correlation between the DoS and other properties of flour and extrudates was found, indicating a good predictive power and applicability of the DoS concept for wheat samples and their product development and specification.Practical ApplicationThe use of sprouted wheat flour for the production of extruded, direct expanded breakfast cereals is a promising opportunity to alter extrudate properties. Thereby, the sprouting temperature can be used as a means affecting the sprouted grain and extrudate properties intentionally and developing products being crunchier, and having an improved cold‐water solubility, a lower density, and a changed expansion behavior. Moreover, due to an increased amount of reducing sugars in sprouted flour, which is a result of an intense starch degradation during sprouting, less additional sugar is needed to produce sweet breakfast extrudates.
Application of gene chip technology in the diagnostic and drug resistance detection of Helicobacter pylori in children
Authors: Yin Guofeng , Bie Shuxian , Gu Hongdan , Shu Xiaoli , Zheng Wei , Peng Kerong , Zhao Hong , Li Fubang , Chen Bo , Botchway Benson O A , Fang Marong , Jiang Mizu 
Published: January 2020

AbstractBackground and AimsHelicobacter pylori (HP) culture for diagnosing HP infection is time‐consuming and technologically complex. This study evaluated the clinical significance of gastric mucosal gene chip technology in the rapid diagnosis of HP infection and detection of drug resistance in children.MethodsPatients (between the age of 2.5 and 16.0 years old) manifesting gastrointestinal symptoms were enrolled in this study. HP culture of gastric mucosa and drug sensitivity test were performed. A gene chip of gastric mucosa was used to detect the presence of HP infection, some single nucleotide polymorphisms in HP drug resistance genes, or associated gene mutation. DNA sequencing was investigated and compared with the gene chip test results.ResultsOut of 267 cases, HP culture was positive in 169 cases and negative in 98 cases. HP detection by the gene chip method was positive in 208 cases and negative in 59 cases. The sensitivity, specificity, and accuracy of the gene chip technology for diagnosing HP infection were 96.1, 85.0, and 93.6%, respectively. HP resistance gene locus using the gene chip showed the main mutation locus of clarithromycin to be 2143A/G, levofloxacin at locus GyrA 91 and GyrA 87, and amoxicillin at PBP1 556ser. Concordance rates between gene chip and DNA sequencing for VacA‐S/M, 16S rRNA, 23S rRNA, and GyrA were greater than 95%, and that of PBP1 was greater than 82%.ConclusionGastric mucosal gene chip technology can be used for rapid diagnosis and drug resistance detection of HP infection in children.
Work–family conflict and psychophysical health conditions of nurses: Gender differences and moderating variables
Authors: Zurlo Maria Clelia , Vallone Federica , Smith Andrew P. 
Published: January 2020

AbstractAimThis study aims to investigate the associations of perceived work–family conflict with nurses' psychophysical health conditions, exploring gender differences and analyzing the potential moderating effects of perceived job control (skill discretion and decision authority), social support, and job satisfaction.MethodsThe study was carried out in five hospitals of the Italian Public Health Service. Participants were 450 nurses (206 men, 244 women). Self‐administered questionnaires were used to collect data. Descriptive statistics and hierarchical regression analyses were conducted.ResultsFemale nurses perceived significantly higher levels of work–family conflict, anxiety, depression and somatization. Significant gender differences emerged in the associations between work–family conflict and nurses' psychological health conditions and in moderating variables. Work–family conflict was significantly associated with anxiety and depression in male nurses and with somatization in both genders. The associations of work–family conflict with nurses' psychophysical health conditions were moderated by decision authority and job satisfaction, in male nurses, and by social support, in female nurses.ConclusionsFindings suggest including gender‐specific moderating variables for defining tailored policies and interventions within healthcare organizations to reduce perceived work–family conflict and to promote nurses' wellbeing.
Sex differences in rapid nonclassical action of 17β‐oestradiol on intracellular signalling and oestrogen receptor α expression in basal forebrain cholinergic neurones in mouse
Authors: Kim SooHyun , Barad Zsuzsanna , Cheong Rachel Y. , Ábrahám István M. 
Published: January 2020

AbstractRapid nonclassical effects of 17β‐oestradiol (E2) on intracellular signalling have been identified in the basal forebrain, although the extent to which these actions may be different in males and females is unknown. Previous work has shown that E2 rapidly phosphorylates cAMP responsive element binding protein (CREB) via ΕRα in female cholinergic neurones. Using this indicator, the present study examined whether nonclassical actions of E2 occur in a sexually dimorphic manner within basal forebrain cholinergic neurones in mice. In addition, we investigated the expression and intracellular distribution of oestrogen receptor (ΕR)α in cholinergic neurones in female and male mice. Animals were gonadectomised and treated 2 weeks later with E2. The number of CREB‐expressing cholinergic neurones was not altered in any of the brain regions after E2 treatment in both males and females. However, E2 treatment rapidly (< 15 minutes) increased (P < 0.05) the number of cholinergic neurones expressing phosphorylated CREB (pCREB) in the substantia innominata and medial septum but not in the striatum in female mice. By contrast, E2 did not change pCREB expression in cholinergic neurones in male mice at any time point (15 minutes, 1 hour, 4 hours), irrespective of the neuroanatomical location. We also observed that, in females, more cholinergic neurones expressed nuclear ΕRα in all regions, whereas males showed more cholinergic neurones with cytoplasmic or both nuclear and cytoplasmic expression of ΕRα. Taken together, these results demonstrate a marked sex difference in the E2‐induced nonclassical effect and intracellular distribution of ΕRα in basal forebrain cholinergic neurones in vivo.
Intralesional injection of bleomycin in the treatment of xanthelasma palpebrarum: A clinical study
Authors: Lin Xianzheng , Hu Hao , Qian Yuxin , Jie Xiang , Nie Bing , Zhao Yao‐Zhong , Wang Hui , Jiang Hua 
Published: January 2020

AbstractBackgroundXanthelasma palpebrarum (XP) is the most common type of cutaneous xanthoma and has been treated with intralesional injection of pingyangmycin effectively. However, bleomycin, which has the same effect in antitumor activity as pingyangmycin, has not been applied in the treatment of XP.AimsTo explore and assess the treatment of xanthelasma by intralesional injection of bleomycin, which has been widely used as an antitumor antibiotic, for the replacement of pingyangmycin.MethodsIntralesional injection of different concentrations of bleomycin was administered to 44 xanthelasma lesions of 24 patients who have never been treated before, divided into two groups according to age. Photographs were taken and analyzed to assess the therapeutic efficiency. Patients were then followed up for 6‐24 months.ResultsAll the lesions resolved after 1 month of treatment with the intralesional injection of different concentrations of bleomycin. There was no significant difference observed between the two groups. No severe complications had occurred.ConclusionThe treatment of XP with intralesional injection of bleomycin is minimally invasive, safe, and effective. Consequently, it also has good cosmetic outcome with no adverse effects.
L.E.A.P.ing into the cosmetic consult
Authors: Watchmaker Jacqueline , Kandula Prasanthi , Kaminer Michael S. 
Published: January 2020

AbstractEstablishing good rapport with patients is important during the initial consult, especially in aesthetic medicine. While experienced physicians develop expertise in cultivating a positive patient experience, younger physicians may benefit from some guidance. We describe the L.E.A.P (Listen, Educate and Empower, Align, Perform) method which may help guide young physicians through a successful cosmetic consult. In addition we will review the B.L.A.S.T (Believe, Listen, Apologize, Satisfy, Thank) method for dealing with unhappy patients.
The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma
Authors: Poté Nicolas , Cros Jérôme , Laouirem Samira , Raffenne Jérôme , Negrão Magda , Albuquerque Miguel , Bedossa Pierre , Godinho Ferreira Miguel , Ait Si Ali Slimane , Fior Rita , Paradis Valérie 
Published: January 2020

AbstractBackground & AimsVascular invasion is a major prognostic factor in hepatocellular carcinoma (HCC). We previously identified histone H4 acetylated at lysine 16 (H4K16ac), a histone modification involved in transcription activation, as a biomarker of microvascular invasion (mVI) in HCC. This study aimed to investigate the role of hMOF, the histone acetyltransferase responsible for H4K16 acetylation, in the process of vascular invasion in HCC.MethodshMOF expression was assessed by RT‐qPCR and immunohistochemistry in a retrospective series of HCC surgical samples, and correlated with the presence of mVI. The functional role of hMOF in HCC vascular invasion was investigated in vitro in HCC cell lines using siRNA, transcriptomic analysis and transwell invasion assay, and in vivo using a Zebrafish embryo xenograft model.ResultsWe found that hMOF was significantly upregulated at the protein level in HCC with mVI, compared with HCC without mVI (P < .01). Transcriptomic analysis showed that hMOF downregulation in HCC cell line lead to significant downregulation of key genes and pathways involved in vascular invasion. These results were confirmed by transwell invasion assay, where hMOF downregulation significantly reduced HCC cells invasion. Finally, hMOF downregulation significantly reduced tumour cell intravasation and metastasis in vivo.ConclusionsAltogether, these results underpin a critical role for hMOF in vascular invasion in HCC, via transcription activation of key genes involved in this process. These data confirm the major role of epigenetic alterations in HCC progression, and pave the way for future therapies targeting hMOF in HCC.
Spoonfeeding is associated with increased infant weight but only amongst formula‐fed infants
Authors: Jones Sara Wyn , Lee Michelle , Brown Amy 
Published: January 2020

AbstractInfant feeding experiences are important for the development of healthy weight gain trajectories. Evidence surrounding milk feeding and timing of introduction to solids is extensive; however, the impact of the method of introducing solids on infant growth has been relatively underexplored. Baby‐led weaning (where infants self‐feed family foods) is proposed to improve appetite regulation, leading to healthier weight gain and a reduced risk of obesity. However, the evidence is mixed and has methodological inconsistencies. Furthermore, despite milk being a large part of the infant diet during the period infants are introduced to solid foods, its influence and interaction with introductory style have not been considered. The aim of this study was to explore growth among infants aged 3–12 months according to both style of introduction to solid foods and milk feeding; 269 infants were weighed and measured, and body mass index (BMI) computed. The results showed that overall, infants who were spoon‐fed (compared with self‐fed) at introduction to complementary feeding (CF) had greater length (but not weight or BMI). However, when milk feeding was accounted for, we found that infants who were both spoon‐fed and fully formula fed had greater weight compared with spoon‐fed, breastfed infants. There was no significant difference in weight among self‐fed infants who were breastfed or formula fed. The results highlight the importance of considering infant feeding as a multicomponent experience in relation to growth, combining both milk feeding and method of CF. This relationship may be explained by differences in maternal feeding style or diet consumed.
Candida biofilm production is associated with higher mortality in patients with candidaemia
Authors: Vitális Eszter , Nagy Fruzsina , Tóth Zoltán , Forgács Lajos , Bozó Aliz , Kardos Gábor , Majoros László , Kovács Renátó 
Published: January 2020

SummaryBackgroundCandidaemia is a common life‐threatening disease among hospitalised patients, but the effect of the Candida biofilm‐forming ability on the clinical outcome remains controversial.ObjectiveThe aim was to determine the impact of biofilms, specifically focusing on biofilm mass and metabolic activity, on the mortality in candidaemia.Patients/MethodsThe clinical data of patients (n = 127) treated at the University of Debrecen, Clinical Centre, between January 2013 and December 2018, were investigated retrospectively. Biofilm formation was assessed using the crystal violet and XTT assays, measuring the biofilm mass and metabolic activity, respectively. Isolates were classified as low, intermediate and high biofilm producers both regarding biofilm mass and metabolic activity. The susceptibility of one‐day‐old biofilms to fluconazole, amphotericin B, anidulafungin, caspofungin and micafungin was evaluated and compared to planktonic susceptibility.ResultsIntermediate/high biofilm mass was associated with significantly higher mortality (61%). All Candida tropicalis, Candida parapsilosis and Candida glabrata isolates originating from fatal infections were intermediate/high biofilm producers, whereas this ratio was 85% for Candida albicans. Solid malignancy was associated with intermediate/high biofilm producers (P = .043). The mortality was significantly higher in infections caused by Candida strains producing biofilms with intermediate/high metabolic activity (62% vs. 33%, P = .010). The ratio of concomitant bacteraemia was higher for isolates forming biofilms with low metabolic activity (53% vs 28%, P = .015).ConclusionsThis study provides evidence that the Candida biofilms especially with intermediate/high metabolic activity are related to higher mortality in candidaemia.
Politicized policy access: The effect of politicization on interest group access to advisory councils
Authors: Willems Evelien 
Published: January 2020

AbstractCurrent scholarship often concludes that technical expertise is one of the most important commodities for interest groups wishing to gain access to political‐administrative venues. Less attention has been given to politicization and the scope of societal support that interest groups bring to bear. Specifically, I hypothesize that the capacity of interest groups to supply broad societal support is decisive for gaining access in highly politicized policy domains. To test this expectation, the article combines a mapping of interest group membership in 616 Belgian advisory councils with survey data from more than 400 organized interests. The empirical analyses demonstrate that interest groups with broad support are more likely to gain access to advisory councils in highly politicized policy domains, but this effect is negatively moderated when interest groups involve their constituencies intensely in advocacy processes.
Expression of the CCCH‐tandem zinc finger protein gene OsTZF5 under a stress‐inducible promoter mitigates the effect of drought stress on rice grain yield under field conditions
Authors: Selvaraj Michael Gomez , Jan Asad , Ishizaki Takuma , Valencia Milton , Dedicova Beata , Maruyama Kyonoshin , Ogata Takuya , Todaka Daisuke , Yamaguchi‐Shinozaki Kazuko , Nakashima Kazuo , Ishitani Manabu 
Published: January 2020

SummaryIncreasing drought resistance without sacrificing grain yield remains an ongoing challenge in crop improvement. In this study, we report that Oryza sativa CCCH‐tandem zinc finger protein 5 (OsTZF5) can confer drought resistance and increase grain yield in transgenic rice plants. Expression of OsTZF5 was induced by abscisic acid, dehydration and cold stress. Upon stress, OsTZF5‐GFP localized to the cytoplasm and cytoplasmic foci. Transgenic rice plants overexpressing OsTZF5 under the constitutive maize ubiquitin promoter exhibited improved survival under drought but also growth retardation. By introducing OsTZF5 behind the stress‐responsive OsNAC6 promoter in two commercial upland cultivars, Curinga and NERICA4, we obtained transgenic plants that showed no growth retardation. Moreover, these plants exhibited significantly increased grain yield compared to non‐transgenic cultivars in different confined field drought environments. Physiological analysis indicated that OsTZF5 promoted both drought tolerance and drought avoidance. Collectively, our results provide strong evidence that OsTZF5 is a useful biotechnological tool to minimize yield losses in rice grown under drought conditions.