bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 1 study of combinatorial sorafenib, G‐CSF, and plerixafor treatment in relapsed/refractory, FLT3‐ITD‐mutated acute myelogenous leukemia patients
Authors: Borthakur Gautam , Zeng Zhihong , Cortes Jorge E. , Chen Hsiang‐Chun , Huang Xuelin , Konopleva Marina , Ravandi Farhad , Kadia Tapan , Patel Keyur P. , Daver Naval , Kelly Mary A. , McQueen Teresa , Wang Ru‐Yiu , Kantarjian Hagop , Andreeff Michael 
Published: July 2020

AbstractStroma‐leukemia interactions mediated by CXCR4, CD44, VLA4, and their respective ligands contribute to therapy resistance in FLT3‐ITD‐mutated acute myelogenous leukemia (AML). We conducted a phase 1 study with the combination of sorafenib (a FLT3‐ITD inhibitor), plerixafor (a SDF‐1/CXCR4 inhibitor), and G‐CSF (that cleaves SDF‐1, CD44, and VLA4). Twenty‐eight patients with relapsed/refractory FLT3‐ITD‐mutated AML were enrolled from December 2010 to December 2013 at three dose levels of sorafenib (400, 600, and 800 mg twice daily) and G‐CSF and plerixafor were administered every other day for seven doses starting on day one. Sorafenib 800 mg twice daily was selected for the expansion phase. While no dose‐limiting toxicities (DLT) were encountered in the four‐week DLT window, hand‐foot syndrome and rash were seen beyond the DLT window, which required dose reductions in most patients. The response rate was 36% (complete response (CR) = 4, complete remission with incomplete platelet recovery (CRp) = 4, complete remission with incomplete hematologic recovery (CRi) = 1, and partial response (PR) = 1) for the intention to treat population. Treatment resulted in 58.4 and 47 mean fold mobilization of blasts and CD34 /38‐ stem/progenitor cells, respectively, to the circulation. Expression of the adhesion molecules CXCR4, CD44, and VLA4 on circulating leukemia cells correlated negatively with the mobilization of CD34+/38‐, CD34+/38−/123+ “progenitor” cells (all P ≤ .002). Mass cytometry analysis of sequential samples from two patients demonstrated resistance emerging early on from sub‐clones with persistent Akt and/or ERK signaling. In conclusion, the strategy of combined inhibition of FLT3 kinase and stromal adhesive interactions has promising activity in relapsed/refractory, FLT3‐ITD‐mutated AML, which warrants further evaluation in the front‐line setting.
Cocrystallization Tailoring Multiple Radiative Decay Pathways for Amplified Spontaneous Emission
Authors: Bolla Geetha , Liao Qing , Amirjalayer Saeed , Tu Zeyi , Lv Shaokai , Liu Jie , Zhang Shuai , Zhen Yonggang , Yi Yuanping , Liu Xinfeng , Fu Hongbing , Fuchs Harald , Dong Huanli , Wang Zhaohui , Hu Wenping 
Published: July 2020

AbstractAmplified spontaneous emission (ASE) is intrinsically associated with lasing applications. Inefficient photon energy transfer to ASE is a long‐standing issue for organic semiconductors that consist of multiple competing radiative decay pathways, far from being rationally regulated from the perspective of molecular arrangements. Herein, we achieve controllable molecular packing motifs by halogen‐bonded cocrystallization, leading to ten times increased radiative decay rate, four times larger ASE radiative decay selectivity and thus remarkable ASE threshold decrease from 223 to 22 μJ cm−2, albeit with a low photoluminescence quantum yield. We have made an in‐depth investigation on the relationship among molecular arrangements, vibration modes, radiative decay profiles and ASE properties. The results suggest that cocrystallization presents a powerful approach to tailor the radiative decay pathways, which is fundamentally important to the development of organic ASE and lasing materials.
N‐Bridged Acyclic Trimeric Poly‐Cyclodiphosphazanes: Highly Tuneable Cyclodiphosphazane Building Blocks
Authors: Shi Xiaoyan , León Felix , Sim Ying , Quek Shina , Hum Gavin , Khoo Yi Xin Joycelyn , Ng Zi Xuan , Par Mian Yang , Ong How Chee , Singh Varun K. , Ganguly Rakesh , Clegg Jack K. , Díaz Jesús , García Felipe 
Published: July 2020

AbstractWe have synthesized a completely new family of acyclic trimeric cyclodiphosphazane compounds comprising NH, NiPr, NtBu and NPh bridging groups. In addition, the first NH‐bridged acyclic dimeric cyclophosphazane has been produced. The trimeric species display highly tuneable characteristics so that the distance between the terminal N(H)R moieties can be readily modulated by the steric bulk present in the bridging groups (ranging from ≈6 to ≈10 Å). Moreover, these species exhibit pronounced topological changes when a weak non‐bonding NH⋅⋅⋅π aryl interaction is introduced. Finally, the NH‐bridged chloride binding affinities have been calculated and benchmarked along with the existing experimental data available for monomeric cyclodiphosphazanes. Our results underscore these species as promising hydrogen bond donors for supramolecular host–guest applications.
Ambient Moisture Accelerates Hydroamination Reactions of Vinylarenes with Alkali‐Metal Amides under Air
Authors: Mulks Florian F. , Bole Leonie J. , Davin Laia , Hernán‐Gómez Alberto , Kennedy Alan , García‐Álvarez Joaquín , Hevia Eva 
Published: July 2020

AbstractA straightforward alkali‐metal‐mediated hydroamination of styrenes using biorenewable 2‐methyltetrahydrofuran as a solvent is reported. Refuting the conventional wisdom of the incompatibility of organolithium reagents with air and moisture, shown here is that the presence of moisture is key in favoring formation of the target phenethylamines over competing olefin polymerization products. The method is also compatible with sodium amides, with the latter showing excellent promise as highly efficient catalysts under inert atmosphere conditions.
Co3O4 Hollow Nanoparticles Embedded in Mesoporous Walls of Carbon Nanoboxes for Efficient Lithium Storage
Authors: Huang Yi , Fang Yongjin , Lu Xue Feng , Luan Deyan , Lou Xiong Wen (David) 
Published: July 2020

AbstractConfining nanostructured electrode materials in porous carbon represents an effective strategy for improving the electrochemical performance of lithium‐ion batteries. Herein, we report the design and synthesis of hybrid hollow nanostructures composed of highly dispersed Co3O4 hollow nanoparticles (sub‐20 nm) embedded in the mesoporous walls of carbon nanoboxes (denoted as H‐Co3O4@MCNBs) as an anode material for lithium‐ion batteries. The facile metal–organic framework (MOF)‐engaged strategy for the synthesis of H‐Co3O4@MCNBs involves chemical etching‐coordination and subsequent two‐step annealing treatments. Owing to the unique structural merits including more active interfacial sites, effectively alleviated volume variation, good and stable electrical contact, and easy access of Li+ ions, the H‐Co3O4@MCNBs exhibit excellent lithium‐storage performance in terms of high specific capacity, excellent rate capability, and cycling stability.
Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis
Authors: Shi Wei , Tang Feng , Ao Jiwei , Yu Qun , Liu Junjie , Tang Yubo , Jiang Bofeng , Ren Xuelian , Huang He , Yang Weibo , Huang Wei 
Published: July 2020

AbstractStrain‐promoted azide–alkyne cycloaddition using dibenzoazacyclooctyne (DBCO) is widely applied in copper‐free bioorthogonal reactions. Reported here is the efficient acid‐promoted rearrangement and silver‐catalyzed amidation of DBCO, which alters its click reactivity robustly. In the switched click reaction, DBCO, as a caged acylation reagent, enables rapid peptide/protein modification after decaging facilitated by silver catalysts, rendering site‐specific conjugation of an IgG antibody by a Fc‐targeting peptide.
Adsorptive Separation of Benzene, Cyclohexene, and Cyclohexane by Amorphous Nonporous Amide Naphthotube Solids
Authors: Yao Huan , Wang Yu‐Mei , Quan Mao , Farooq M. Umar , Yang Liu‐Pan , Jiang Wei 
Published: July 2020

AbstractBenzene hydrogenation is an important industrial process. The reaction is incomplete, resulting in a mixture of benzene, cyclohexane, and/or cyclohexene that have to be separated before any further reactions. The currently used extractive and azeotropic distillations are operationally complex and energy intensive. Adsorptive separation provides an alternative energy‐efficient method. However, the separation of the ternary mixture by adsorptive separation has not yet been reported. In the present research, we report two macrocyclic hosts with hydrogen‐bonding sites in their cavities that are able to separate the ternary mixture of benzene, cyclohexene, and cyclohexane. N−H⋅⋅⋅π interactions were found to play a key role in the selective separation. In addition, fast adsorption, high loading ratios, and easy recycling are achieved with the present system, which is promising for practical applications.
Efficient Trapping of Trace Acetylene from Ethylene in an Ultramicroporous Metal–Organic Framework: Synergistic Effect of High‐Density Open Metal and Electronegative Sites
Authors: Zhang Zhaoqiang , Peh Shing Bo , Wang Yuxiang , Kang Chengjun , Fan Weidong , Zhao Dan 
Published: July 2020

AbstractAcetylene (C2H2) removal from ethylene (C2H4) is a crucial step in the production of polymer‐grade C2H4but remains a daunting challenge because of the similar physicochemical properties of C2H2and C2H4. Currently energy‐intensive cryogenic distillation processes are used to separate the two gases industrially. A robust ultramicroporous metal–organic framework (MOF), Ni3(pzdc)2(7 Hade)2, is reported for efficient C2H2/C2H4separation. The MOF comprises hydrogen‐bonded linked one‐dimensional (1D) chains, and features high‐density open metal sites (2.7 nm−3) and electronegative oxygen and nitrogen sites arranged on the pore surface as cooperative binding sites. Theoretical calculations, in situ powder X‐ray diffraction and Fourier‐transform infrared spectroscopy revealed a synergistic adsorption mechanism. The MOF possesses S‐shaped 1D pore channels that efficiently trap trace C2H2at 0.01 bar with a high C2H2uptake of 60.6 cm3 cm−3and C2H2/C2H4selectivity.
Probing CO2 Reduction Pathways for Copper Catalysis Using an Ionic Liquid as a Chemical Trapping Agent
Authors: Zhang Gui‐Rong , Straub Sascha‐Dominic , Shen Liu‐Liu , Hermans Yannick , Schmatz Patrick , Reichert Andreas M. , Hofmann Jan P. , Katsounaros Ioannis , Etzold Bastian J. M. 
Published: July 2020

AbstractThe key to fully leveraging the potential of the electrochemical CO2 reduction reaction (CO2RR) to achieve a sustainable solar‐power‐based economy is the development of high‐performance electrocatalysts. The development process relies heavily on trial and error methods due to poor mechanistic understanding of the reaction. Demonstrated here is that ionic liquids (ILs) can be employed as a chemical trapping agent to probe CO2RR mechanistic pathways. This method is implemented by introducing a small amount of an IL ([BMIm][NTf2]) to a copper foam catalyst, on which a wide range of CO2RR products, including formate, CO, alcohols, and hydrocarbons, can be produced. The IL can selectively suppress the formation of ethylene, ethanol and n‐propanol while having little impact on others. Thus, reaction networks leading to various products can be disentangled. The results shed new light on the mechanistic understanding of the CO2RR, and provide guidelines for modulating the CO2RR properties. Chemical trapping using an IL adds to the toolbox to deduce the mechanistic understanding of electrocatalysis and could be applied to other reactions as well.
Movement ecology of imperilled fish in a novel ecosystem: River‐reservoir movements by razorback sucker and translocations to aid conservation
Authors: Pennock Casey A. , McKinstry Mark C. , Cathcart Charles N. , Gido Keith B. , Francis Travis A. , Hines Brian A. , MacKinnon Peter D. , Hedden Skyler C. , Gilbert Eliza I. , Cheek Christopher A. , Speas David W. , Creighton Katherine , Elverud Darek S. , Schleicher Benjamin J. 
Published: July 2020

Abstract

Reservoirs and associated river fragments are novel ecosystems not experienced by fishes in their evolutionary history, yet they are now commonplace across the globe. Understanding how fishes use these novel habitats is vital to conservation efforts in contemporary riverscapes.
Movement patterns of the endangered razorback sucker (Xyrauchen texanus) synthesized from tagging efforts in the upper Colorado River basin, USA, illustrate the applications of tagging technology and data sharing by multiple agencies to better understand the spatial ecology of large river fishes.
Tagging studies between 2014 and 2018 in Lake Powell and its two main tributary rivers, the Colorado (unfragmented) and San Juan (waterfall‐fragmented), were used to quantify movement of razorback sucker within this river–reservoir habitat complex. In addition, facilitated translocations of fish upstream of a waterfall barrier in the San Juan River were assessed in 2016–2017.
Extensive movement of fish occurred within and across river and reservoir habitats. Of 722 fish captured in the Colorado River arm of Lake Powell, 36% of re‐encounters occurred upstream in the Colorado or Green rivers, or fish dispersed through the reservoir and were detected in the San Juan River arm. Fourteen fish moved more than 600 km. In the San Juan arm of the reservoir, 29% and 20% of fish in 2017 and 2018, respectively, had moved ~30–40 km upstream below the waterfall in the San Juan River within a year. In 2016–2017, 303 fish were translocated upstream of the waterfall into the San Juan River, but 80% were re‐encountered downstream of the waterfall within a year.
Long‐distance movements by razorback sucker were common within and among rivers and reservoirs illustrating how large river fish, in general, might maintain population connectivity in highly altered ecosystems.
Understanding the Glycopeptide Antibiotic Crosslinking Cascade: In Vitro Approaches Reveal the Details of a Complex Biosynthesis Pathway
Authors: Zhao Yongwei , Ho Y. T. Candace , Tailhades Julien , Cryle Max 
Published: July 2020

AbstractThe glycopeptide antibiotics (GPAs) are a fascinating example of complex natural product biosynthesis, with the nonribosomal synthesis of the peptide core coupled to a cytochrome P450‐mediated cyclisation cascade that crosslinks aromatic side chains within this peptide. Given that the challenges associated with the synthesis of GPAs stems from their highly crosslinked structure, there is great interest in understanding how biosynthesis accomplishes this challenging set of transformations. In this regard, the use of in vitro experiments has delivered important insights into this process, including the identification of the unique role of the X‐domain as a platform for P450 recruitment. In this minireview, we present an analysis of the results of in vitro studies into the GPA cyclisation cascade that have demonstrated both the tolerances and limitations of this process for modified substrates, and in turn developed rules for the future reengineering of this important antibiotic class.
Photo‐biohydrogen Production by Photosensitization with Biologically Precipitated Cadmium Sulfide in Hydrogen‐Forming Recombinant Escherichia coli
Authors: Honda Yuki , Shinohara Yuka , Watanabe Motonori , Ishihara Tatsumi , Fujii Hiroshi 
Published: July 2020

AbstractAn inorganic‐biological hybrid system that integrates features of both stable and efficient semiconductors and selective and efficient enzymes is attractive for facilitating the conversion of solar energy to hydrogen. In this study, we aimed to develop a new photocatalytic hydrogen‐production system based on Escherichia coli whole‐cell genetically engineered as a biocatalysis for highly active hydrogen formation. The photocatalysis part was obtained by bacterial precipitation of cadmium sulfide (CdS), which is a visible‐light‐responsive semiconductor. The recombinant E. coli cells were sequentially subjected to CdS precipitation and heterologous [FeFe]‐hydrogenase synthesis to yield a CdS@E. coli hybrid capable of light energy conversion and hydrogen formation in a single cell. The CdS@E. coli hybrid achieved photocatalytic hydrogen production with a sacrificial electron donor, thus demonstrating the feasibility of our system and expanding the current knowledge of photosensitization using a whole‐cell biocatalyst with a bacterially precipitated semiconductor.
Epistaxis management on COVID‐19–positive patients: Our early case experience and treatment
Authors: Bathula Samba Siva R. , Patrick Tyler , Srikantha Luxman 
Published: July 2020

AbstractEpistaxis management on COVID‐19 patients is concerning for otolaryngologists due to the highly virulence and increased concentration within respiratory droplets and nasal secretions. Authors suggest initial management with oxymetazoline nasal drops and local pressure before considering nasal packing with absorbable material to prevent COVID‐19 transmission to surrounding healthcare workers.
Recent progress and challenges of carbon materials for Zn‐ion hybrid supercapacitors
Authors: Liu Qiyu , Zhang Haozhe , Xie Jinhao , Liu Xiaoqing , Lu Xihong 
Published: July 2020

AbstractZinc‐ion hybrid supercapacitors (ZHSCs) have garnered increasing attention as promising energy storage devices in recent years, as they combine the advantages of high‐energy Zn‐ion batteries and high‐power supercapacitors. However, the development of ZHSCs is still in its infancy and there are many bottlenecks to overcome. In particular, the challenge induced by the limited ion adsorption capability of carbon‐positive electrodes severely restricts the energy density of ZHSCs. Therefore, it has become a key issue to design novel carbon‐positive electrodes that enable high energy density yet do not deteriorate the intrinsic power capability and long‐term durability. This study focuses on recent achievements in synthesis, morphology, and electrochemical performance of various carbon materials applied in ZHSCs. The modification strategies to optimize their electrochemical performance are briefly summarized. In addition, current challenges and future opportunities in this field are also outlined. This review will be beneficial to provide an organized framework for the research systems of carbon‐positive electrodes and develop novel ZHSCs with high energy density.
Synthesis and Applications of Cinchona Squaramide‐Modified Poly(Glycidyl Methacrylate) Microspheres as Recyclable Polymer‐Grafted Enantioselective Organocatalysts
Authors: Nagy Sándor , Fehér Zsuzsanna , Kárpáti Levente , Bagi Péter , Kisszékelyi Péter , Koczka Béla , Huszthy Péter , Pukánszky Béla , Kupai József 
Published: July 2020

AbstractThis work presents the immobilization of cinchona squaramide organocatalysts on poly(glycidyl methacrylate) solid supports. Preparation of the well‐defined monodisperse polymer microspheres was facilitated by comprehensive parameter optimization. By exploiting the reactive epoxy groups of the polymer support, three amino‐functionalized cinchona derivatives were immobilized on this carrier. To explore the effect of the amino linker, these structurally varied precatalysts were synthesized by modifying the cinchona skeleton at different positions. The catalytic activities of the immobilized organocatalysts were tested in the Michael addition of pentane‐2,4‐dione and trans‐β‐nitrostyrene with excellent yields (up to 98 %) and enantioselectivities (up to 96 % ee). Finally, the catalysts were easily recovered five times by centrifugation without loss of activity.
Distinct Helical Molecular Orbitals through Conformational Lock**
Authors: Ozcelik Ani , Aranda Daniel , Gil‐Guerrero Sara , Pola‐Otero Xaquín A. , Talavera Maria , Wang Liangxuan , Behera Santosh Kumar , Gierschner Johannes , Peña‐Gallego Ángeles , Santoro Fabrizio , Pereira‐Cameselle Raquel , Alonso‐Gómez J. Lorenzo 
Published: July 2020

AbstractSeveral theoretical studies have proposed strategies to generate helical molecular orbitals (Hel‐MOs) in [n]cumulenes and oligoynes. While chiral even‐[n] cumulenes feature Hel‐MOs, odd‐[n] cumulenes may also present them if the terminal groups lie in different planes. However, the proposed systems have been either experimentally unfeasible or resulted in opposite pseudo‐degenerated Hel‐MOs. We hereby demonstrate the introduction of a remarkable energy difference between helical orbitals of opposite twist by fixing the torsion angle between the terminal groups in butadiyne fragments. To experimentally lock the conformation of the terminal groups, we designed and synthesized cyclic architectures by combining acetylenes with chiral spirobifluorenes. The high stability of these systems with distinct helical orbitals allowed their isolation and full characterization. In our view, these results constitute a step further in the development of real systems presenting helical molecular orbitals.
A Reversible Liquid‐to‐Liquid Organic Hydrogen Carrier System Based on Ethylene Glycol and Ethanol
Authors: Zhou Quan‐Quan , Zou You‐Quan , Ben‐David Yehoshoa , Milstein David 
Published: July 2020

AbstractLiquid organic hydrogen carriers (LOHCs) are powerful systems for the efficient unloading and loading molecular hydrogen. Herein, a liquid‐to‐liquid organic hydrogen carrier system based on reversible dehydrogenative coupling of ethylene glycol (EG) with ethanol catalysed by ruthenium pincer complexes is reported. Noticeable advantages of the current LOHC system is that both reactants (hydrogen‐rich components) and the produced esters (hydrogen‐lean components) are liquids at room temperature, and the dehydrogenation process can be performed under solvent and base‐free conditions. Moreover, the hydrogenation reaction proceeds under low hydrogen pressure (5 bar), and the LOHC system has a relatively high theoretical gravimetric hydrogen storage capacity (HSC>5.0 wt %), presenting an attractive hydrogen storage system.
Copper‐Catalyzed Oxidative Cross‐Coupling of Electron‐Deficient Polyfluorophenylboronate Esters with Terminal Alkynes
Authors: Liu Zhiqiang , Budiman Yudha P. , Tian Ya‐Ming , Friedrich Alexandra , Huang Mingming , Westcott Stephen A. , Radius Udo , Marder Todd B. 
Published: July 2020

AbstractWe report herein a mild procedure for the copper‐catalyzed oxidative cross‐coupling of electron‐deficient polyfluorophenylboronate esters with terminal alkynes. This method displays good functional group tolerance and broad substrate scope, generating cross‐coupled alkynyl(fluoro)arene products in moderate to excellent yields. Thus, it represents a simple alternative to the conventional Sonogashira reaction.
Computational Analysis of Mesomerism in para‐Substituted mer‐NCN Pincer Platinum(II) Complexes, Including its Relationships with Hammett σp Substituent Parameters
Authors: Canty Allan J. , Ariafard Alireza , van Koten Gerard 
Published: July 2020

AbstractDensity Functional Theory studies of square‐planar PtII pincer structures, (4‐Z‐NCN)PtCl ([4‐Z‐NCN]−=[4‐Z‐2,6‐(Me2NCH2)2C6H2‐N,C,N]−, Z=H, NO2, CF3, CO2H, CHO, Cl, Br, I, F, SMe, SiMe3, tBu, OH, NH2, NMe2), enable characterisation of mesomerism for the pincer‐Pt interaction. Relationships between Hammett σp substituent parameters of Z and DFT data obtained from NBO6 and AOMix computation are used to probe the interaction of the 5dyz orbital of platinum with π‐orbitals of the arene ring. Analogous computation for 2,6‐(Me2CH2)2C6H3Z (Z=H, CF3, CHO, Cl, Br, I, F, SMe, SiMe3, tBu, OH, NH2) and (4‐H‐NCN)PtZ allows an estimation of the relative substituent effects of “(CH2NMe2)2PtZ” on π‐delocalisation in the pincer system.