bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma
Authors: Tap William D. , Villalobos Victor M. , Cote Gregory M. , Burris Howard , Janku Filip , Mir Olivier , Beeram Murali , Wagner Andrew J. , Jiang Liewen , Wu Bin , Choe Sung , Yen Katharine , Gliser Camelia , Fan Bin , Agresta Sam , Pandya Shuchi S. , Trent Jonathan C. 
Published: March 2020

PURPOSE Surgery is the primary therapy for localized chondrosarcoma; for locally advanced and/or metastatic disease, no known effective systemic therapy exists. Mutations in the isocitrate dehydrogenase 1/2 (IDH1/2) enzymes occur in up to 65% of chondrosarcomas, resulting in accumulation of the oncometabolite D-2-hydroxyglutarate (2-HG). Ivosidenib (AG-120) is a selective inhibitor of mutant IDH1 approved in the United States for specific cases of acute myeloid leukemia. We report outcomes of patients with advanced chondrosarcoma in an ongoing study exploring ivosidenib treatment. PATIENTS AND METHODS This phase I multicenter open-label dose-escalation and expansion study of ivosidenib monotherapy enrolled patients with mutant IDH1 advanced solid tumors, including chondrosarcoma. Ivosidenib was administered orally (100 mg twice daily to 1,200 mg once daily) in continuous 28-day cycles. Responses were assessed every other cycle using RECIST (version 1.1). RESULTS Twenty-one patients (escalation, n = 12; expansion, n = 9) with advanced chondrosarcoma received ivosidenib (women, n = 8; median age, 55 years; range, 30-88 years; 11 had received prior systemic therapy). Treatment-emergent adverse events (AEs) were mostly grade 1 or 2. Twelve patients experienced grade ≥ 3 AEs; only one event was judged treatment related (hypophosphatemia, n = 1). Plasma 2-HG levels decreased substantially in all patients (range, 14%-94.2%), to levels seen in healthy individuals. Median progression-free survival (PFS) was 5.6 months (95% CI, 1.9 to 7.4 months); the PFS rate at 6 months was 39.5%. Eleven (52%) of 21 patients experienced stable disease. CONCLUSION In patients with chondrosarcoma, ivosidenib showed minimal toxicity, substantial 2-HG reduction, and durable disease control. Future studies of ivosidenib monotherapy or rational combination approaches should be considered in patients with advanced mutant IDH1 chondrosarcoma.
Randomized, Phase II Study of Trastuzumab Beyond Progression in Patients With HER2-Positive Advanced Gastric or Gastroesophageal Junction Cancer: WJOG7112G (T-ACT Study)
Authors: Makiyama Akitaka , Sukawa Yasutaka , Kashiwada Tomomi , Kawada Junji , Hosokawa Ayumu , Horie Yoshiki , Tsuji Akihito , Moriwaki Toshikazu , Tanioka Hiroaki , Shinozaki Katsunori , Uchino Keita , Yasui Hirofumi , Tsukuda Hiroshi , Nishikawa Kazuhiro , Ishida Hiroyasu , Yamanaka Takeharu , Yamazaki Kentaro , Hironaka Shuichi , Esaki Taito , Boku Narikazu , Hyodo Ichinosuke , Muro Kei 
Published: March 2020

PURPOSE This study evaluated the continuous use of trastuzumab beyond progression (TBP) in human epidermal growth factor receptor 2 (HER2)-positive advanced gastric or gastroesophageal junction (G/GEJ) cancer. PATIENTS AND METHODS Patients with HER2-positive advanced G/GEJ cancer refractory to first-line chemotherapy with trastuzumab in combination with fluoropyrimidine and platinum were eligible. Patients were randomly assigned to the paclitaxel (80 mg/m2, days 1, 8, and 15, every 4 weeks) or paclitaxel with trastuzumab (PT; initially 8 mg/kg followed by 6 mg/kg, every 3 weeks) arms. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), response rate, and safety. Biomarkers such as HER2 expression status in tumor tissue after first-line treatment, HER2 amplification evaluated in serum cell-free DNA, and soluble HER2 levels were analyzed. RESULTS Overall, 91 patients were allocated to the paclitaxel (n = 46) and PT (n = 45) arms. The median PFS in the paclitaxel and PT arms was 3.2 and 3.7 months, respectively (hazard ratio [HR], 0.91; 80% CI, 0.67 to 1.22; P = .33), and the median OS in both arms was 10 months (HR, 1.2; 95% CI, 0.75 to 2.0; P = .20). The overall response rates in the paclitaxel and PT arms were 32% and 33%, respectively ( P = 1.00), and safety was comparable between the 2 arms. On exploratory analyses, HER2 positivity of tumor tissues was lost after first-line chemotherapy in 11 (69%) of 16 patients whose tumor tissues were available, and circulating HER2 DNA amplification was detected in 41 (60%) of 68 patients. However, no biomarkers associated with efficacy of TBP were found. CONCLUSION The TBP strategy failed to improve PFS in patients with HER2-positive advanced G/GEJ cancer, and no beneficial biomarkers were found.
Fabrication of a mesoporous silica film based optical waveguide sensor for detection of small molecules
Authors: Wang Guiqiang , Sun Shuqing 
Published: March 2020

In this paper, a thick mesoporous silica film (MSF) (more than 700 nm) was fabricated via the two-step enhancing Stöber solution growth approach (ESSGA). According to the optimization based on the transfer matrix method, a thicker MSF sensor has higher waveguide index sensitivity and is more suitable for the adsorbent detection, while a thinner MSF sensor has higher covered medium index sensitivity and is more appropriate for non-adsorbent detection. The covered medium index sensitivity and refractive index resolution of the fabricated MSF optical waveguide sensor were calculated to be 53.18 deg/RIU and

1.28

×

10

−
6

R
I
U

, respectively. For the detection of a small molecule, hexadecyltrimethylammonium bromide was used as a model of a small molecule to verify its sensing property and its limit of detection (LOD) as low as 1.879 nM was obtained. In order to detect heavy metal ions, the MSF was modified with an amino group by the post-grafted method. The response of the resonance angle shift is more sensitive to

P
b

2
+

ion than

C
u

2
+

ion and both their LODs could reach the nanomolar detection level; those are 17.30 and 6.44 nM, respectively.
Filter construction using Ronchi masks and Legendre polynomials to
analyze the noise in aberrations by applying the irradiance transport
equation
Authors: Arriaga Hernández J. A. , Cuevas Otahola B. T. , Oliveros J. , Jaramillo Núñez A. , Morín Castillo M. 
Published: March 2020

We tested different optical elements placed in three different
positions by applying the irradiance transport equation (ITE),
obtaining the wavefront

[
W
(
x
,
y
)
]

and aberration surface
[

AS

(
r
,
θ
)

]. The existing noise in the captures

I

as well as in the

W

and

A
S

were analyzed applying several
filters: first a filter based on Legendre polynomials (LP), generating
the most probable points increasing the data resolution; second, a
filter based on a 50 deg 2D-LP was used as a multilineal fit (multiple
linear regression); and third, an ideal bandpass filter in the Fourier
space after inducing a periodicity using Ronchi simulated masks with
periods in

x
,
y
,
x
y

was used to perform data scanning
(similar to the four-step phase-shifting method). Signal-to-noise
ratio values were obtained for each proposed filter along with the
most probable image free from noise, determined from a linear
combination of the original data and the applied filters.
Agriculture and Law in Japanese Society
Authors: Shimogaki Shinji 
Published: March 2020

This study analyzes the changes in farmland system in Japan. The main policy of post-World War II Japan was regulation of the transfer lease or ownership of farmland, and the conversion of agricultural land into non-agricultural land considering the importance of farmlands. Paradoxically, this policy created some problems, such subdivision of farmland and ownerless lands. To address these problems, the Farmland Intermediary Management Institution was established in 2014 to accelerate farmland concentration and intensify the power of core farmers. In 2016, The Agricultural Land Act was reformed to make it easier for stock companies to own farmland. And, ICT has enabled us to visualize and verbalize tacit knowledge. This study explores the outcomes of these reforms and other unanswered issues.
Genes Encoding Recognition of theCladosporium fulvumEffector Protein Ecp5 Are Encoded at Several Loci in the Tomato Genome
Authors: Iakovidis Michail , Soumpourou Eleni , Anderson Elisabeth , Etherington Graham , Yourstone Scott , Thomas Colwyn 
Published: March 2020

AbstractThe molecular interactions between tomato and Cladosporium fulvum have been an important model for molecular plant pathology. Complex genetic loci on tomato chromosomes 1 and 6 harbor genes for resistance to Cladosporium fulvum, encoding receptor like-proteins that perceive distinct Cladosporium fulvum effectors and trigger plant defenses. Here, we report classical mapping strategies for loci in tomato accessions that respond to Cladosporium fulvum effector Ecp5, which is very sequence-monomorphic. We screened 139 wild tomato accessions for an Ecp5-induced hypersensitive response, and in five accessions, the Ecp5-induced hypersensitive response segregated as a monogenic trait, mapping to distinct loci in the tomato genome. We identified at least three loci on chromosomes 1, 7 and 12 that harbor distinct Cf-Ecp5 genes in four different accessions. Our mapping showed that the Cf-Ecp5 in Solanum pimpinellifolium G1.1161 is located at the Milky Way locus. The Cf-Ecp5 in Solanum pimpinellifolium LA0722 was mapped to the bottom arm of chromosome 7, while the Cf-Ecp5 genes in Solanum lycopersicum Ontario 7522 and Solanum pimpinellifolium LA2852 were mapped to the same locus on the top arm of chromosome 12. Bi-parental crosses between accessions carrying distinct Cf-Ecp5 genes revealed putative genetically unlinked suppressors of the Ecp5-induced hypersensitive response. Our mapping also showed that Cf-11 is located on chromosome 11, close to the Cf-3 locus. The Ecp5-induced hypersensitive response is widely distributed within tomato species and is variable in strength. This novel example of convergent evolution could be used for choosing different functional Cf-Ecp5 genes according to individual plant breeding needs.
Risk factors for attention-deficit/hyperactivity disorder: a case-control study in 5 to 12 years old children
Authors: Soheilipour Fahimeh , Shiri Sareh , Ahmadkhaniha Hamid Reza , Abdollahi Ebrahim , Hosseini-Baharanchi Fatemeh Sadat 
Published: March 2020

Background and aims. Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder known by a pattern of diminished sustained attention and increased impulsivity or hyperactivity. This study aimed to evaluate the risk factors associated with ADHD.
Methods. This case-control study included 297 ADHD children aged 5-12 years admitted to Tehran Institute of Psychiatry, Iran (2012-2013). They were compared with 297 non-ADHD (as controls matched to cases 1:1) who were of the same age (±1 years) selected from outpatients in general pediatric medical centers in Tehran. ADHD Rating Scale IV (ADHD-RS-IV)-Home Version was used to confirm ADHD. Data were analyzed using conditional binary logistic regression.
Results. Mean±SD age were 8.18±3.11 and 8.11±2.9 years in the case and control groups, respectively (P=0.61). Mean±SD birth weight (BW) was higher in ADHD patients compared with the controls (3245.09±0.66 vs 3026.56±0.45 gr, P=0.045). The results showed that odds of ADHD in children with high BW (>3500g) was 3.36 (1.96-5.78) times the odds of ADHD in normal BW children (2500-3500g) controlling for other risk factors. ADHD risk in low BW children (<2500 g) was not statistically different compared with normal BW children [OR:1.74 (0.7-3.7)]. Experience of neonatal disease, fewer offspring, lower level of mothers’ education, and preterm delivery were also risk factors for higher odds of ADHD.
Conclusion. Based on our sample, preterm birth, neonatal disease, high BW, lower level of mother's education, and fewer offspring were ADHD risk factors.
Case report of abdominal left upper quadrant collection secondary to fish bone perforation
Authors: Gheorghiu Marcel Ioan , Bolliet Marion , David Patrice , Denis Bernard 
Published: March 2020

We present an unusual case of an intra-abdominal collection which evidenced a rare etiology and raises diagnostic particularities.
Background. Fish bones ingestion is frequent, but seldom followed by complications. Those are often reported at specific sites.
Objectives. This case report emphasizes the unusual presentation and site localization of a colonic perforation by a small fish bone, in the context of limited radiological accuracy at the diagnostic phase.
Case presentation. A 37 year old male was admitted to the gastroenterology ward with upper and left sided abdominal pain associated with fever and marked fatigue. His medical history was marked by a sleeve gastrectomy in 2010 for obesity. Abdominal signs and elevated acute inflammatory syndrome on blood tests were followed by computer tomography which revealed a pericolic mass near the left splenic flexure. The pain and fever increased in intensity, so a laparotomy was proposed. Intraoperatively, a tumor-like lesion was found and a resection with oncologic limits was performed. Microscopic examination of the specimen revealed a fish bone, but only after surgery did the patient confirm that he had eaten fish meal the week before. The post-operative period was uneventful.
Conclusion. Fish bones remain some of the most frequently ingested alimentary foreign bodies; they may cause atypical clinical presentations, frequently omitted by the patients themselves if symptoms appear delayed. They could also lead to possible high-risk complications which need to be addressed by surgeons.
Kebijakan Nabi Muhammad Saw Menangani Wabah Penyakit Menular dan Implementasinya dalam Konteks Penanggulangan Coronavirus Covid-19
Authors: Mukharom Mukharom , Aravik Havis 
Published: March 2020

AbstractThis study discusses the corona virus that occurred in parts of the world, including Indonesia to find solutions in the form of policies issued by the government, with reference to events in the time of the Prophet Muhammad, including his policy in dealing with outbreaks in the masses, this research is descriptive qualitative using primary and secondary data related to the history of the Prophet Muhammad in solving infectious disease cases. The results of this study indicate that the corona virus outbreak was not much different from the conditions in the mass of the Prophet Muhammad, by the presence of the bubonic plague and leprosy at that time. The policy is to quarantine the area both inside and outside the area, so it does not spread. In the current context, related to Covid 19 cases, lockdown or social distance solutions, including finding the anti-virus immediately, so that it can treat and stop its spread. Keywords: Policy, Viruses, Corona, Lockdown. Social distance. Abstrak Penelitian ini membahas tentang Virus corona yang terjadi di belahan dunia, termasuk Indonesia untuk menemukan solusi dalam bentuk kebijakan yang dikeluarkan oleh pemerintah, dengan merujuk pada kejadian di masa Rasulullah Muhammad, termasuk kebijakannya dalam mengatasi wabah pada massa itu, penelitian ini bersifat deskriptif kualitatif dengan menggunakan data primer dan sekunder yang berhubungan dengan sejarah Nabi Muhammad dalam menyelesaikan kasus penyakit menular. Hasil penelitian ini memperlihatkan bahwa wabah virus corona tidak jauh beda dengan kondisi di massa Rasulullah Muhammad Saw, dengan adanya wabah pes dan lepra pada saat itu. Kebijakannya adalah melakukan karantina wilayah baik ke dalam maupun keluar wilayah, sehingga tidak menyebar. Dalam konteks saat ini, terkait kasus covid 19, lokckdown atau social distance solusinya, termasuk segera menemukan anti virusnya, sehingga dapat mengobati dan menghentikan penyebarannya.Kata Kunci: Kebijakan, Virus, Corona, Lockdown. Social distance.
Ceftazidime–avibactam and ceftolozane–tazobactam susceptibility of multidrug resistant Pseudomonas aeruginosa strains in Hungary
Authors: O'Neall Dustin , Juhász Emese , Tóth Ákos , Urbán Edit , Szabó Judit , Melegh Szilvia , Katona Katalin , Kristóf Katalin 
Published: March 2020

Abstract
Our objective was to compare the activity ceftazidime-avibactam (C/A) and ceftolozane–tazobactam (C/T) against multidrug (including carbapenem) resistant Pseudomonas aeruginosa clinical isolates collected from six diagnostic centers in Hungary and to reveal the genetic background of their carbapenem resistance.
Two hundred and fifty consecutive, non-duplicate, carbapenem-resistant multidrug resistant (MDR) P. aeruginosa isolates were collected in 2017. Minimal inhibitory concentration values of ceftazidime, cefepime, piperacillin/tazobactam, C/A and C/T were determined by broth microdilution method and gradient diffusion test. Carbapenem inactivation method (CIM) test was performed on all isolates. Carbapenemase-encoding blaVIM, blaIMP, blaKPC, blaOXA-48-like and blaNDM genes were identified by multiplex PCR.
Of the isolates tested, 33.6% and 32.4% showed resistance to C/A and C/T, respectively. According to the CIM test results, 26% of the isolates were classified as carbapenemase producers. The susceptibility of P. aeruginosa isolates to C/A and C/T without carbapenemase production was 89% and 91%, respectively. Of the CIM-positive isolates, 80% were positive for blaVIM and 11% for blaNDM. The prevalence of Verona integron-encoded metallo-beta-lactamase (VIM)-type carbapenemase was 20.8%. NDM was present in 2.8% of the isolates.
Although the rate of carbapenemase-producing P. aeruginosa strains is high, a negative CIM result indicates that either C/A or C/T could be effective even if carbapenem resistance has been observed.
OPTIMIZATION OF LONG-RANGE TRAJECTORY FOR AN UNPOWERED FLIGHT VEHICLE
Authors: Pham Tuan Hung , Nguyen Duc Cuong , Nguyen Duc Thanh 
Published: March 2020

This report presents problems of optimization of long-range trajectory for an unpowered flight vehicle at subsonic and transonic speed. The results may be recommended to have a new long range trajectory. The optimization problem is solved by numerical experiments while the normal load factor (normal acceleration) is used as optimization variables with compliance to flight constraints. The focus problem of this study is the investigation of the possibility of trajectory expansion according to the criteria of the maximum range in the first stage of the trajectory.
Pre-Sinkhole Seismicity at the Napoleonville Salt Dome: Implications for Local Seismic Monitoring of Underground Caverns
Authors: Ford Sean R. , Dreger Douglas S. 
Published: March 2020

Abstract
The formation of a sinkhole at the Napoleonville salt dome located near Bayou Corne in Assumption Parish, Louisiana, was preceded by an increase in seismicity, as observed 10 km away by a continuously recording broadband seismic sensor. The seismicity rate in the days prior to the sinkhole formation contained hundreds of long-period events, some of which could be detected using a power detector (short-term to long-term energy ratio) tuned to the duration and frequency content of the seismicity. A characteristic of some of these events is a resonance near 0.4 Hz, which could be due to either an acoustic resonance within the brine-filled cavity or possibly due to unsteady fluid flow through a crack. A more exhaustive catalog was obtained using some of the events detected by the power detector as templates in a correlation detector. The full pre-sinkhole sequence of detections could offer lessons in remote monitoring of underground caverns.
The Impact of Human Capital Development on Economic Growth in Ethiopia: Evidence from ARDL Approach to Co-Integration
Authors: Gebrehiwot Kidanemariam Gidey 
Published: March 2020

The main objective of the study was to investigate the long run and short run impact of human capital on economic growth in Ethiopia (using real GDP per capita, as a proxy for economic growth) over the period 1974/75-2010/2011. The ARDL Approach to Co-integration and Error Correction Model are applied in order to investigate the long-run and short run impact of Human capital on Economic growth. The finding of the Bounds test shows that there is a stable long run relationship between real GDP per capita, education human capital, health human capital, labor force, gross capital formation, government expenditure and official development assistance. The estimated long run model revels that human capital in the form of health (proxied by the ratio of public expenditure on health to real GDP) is the main contributor to real GDP per capita rise followed by education human capital (proxied by secondary school enrolment). Such findings are consistent with the endogenous growth theories which argue that an improvement in human capital (skilled and healthy workers) improves productivity. In the short run, the coefficient of error correction term is -0.7366 suggesting about 73.66 percent annual adjustment towards long run equilibrium. This is another proof for the existence of a stable long run relationship among the variables. The estimated coefficients of the short-run model indicate that education is the main contributor to real GDP per capita change followed by gross capital formation (one period lagged value) and government expenditure (one period lagged value). But, unlike its long run significant impact, health has no significant short run impact on the economy. Even its one period lag has a significant negative impact on the economy.
The above results have an important policy implication. The findings of this paper imply that economic performance can be improved significantly when the ratio of public expenditure on health services to GDP increases and when secondary school enrolment improves. Such improvements have a large impact on human productivity which leads to improved national output per capita. Hence policy makers and / or the government should strive to create institutional capacity that increase school enrolment and improved basic health service by strengthening the infrastructure of educational and health institutions that produce quality manpower. In addition to its effort, the government should continue its leadership role in creating enabling environment that encourage better investment in human capital (education and health) by the private sector.
The Current Status of Corporate Social Responsibility Disclosure of Islamic Shari-based Banking Companies in Bangladesh
Authors: Hossain Md. Sumon , Neogy Taposh Kumar 
Published: March 2020

The purpose of this study is to examine the current extent and any difference (if any) of CSR disclosure of Islamic Sharia-based banking companies in Bangladesh during the period of 2011-2015. Content analysis is adopted to accumulate the data from company’s annual reports. The CSR checklist comprise of sixteen dimensions (including 85 items) of CSR activities i.e., ‘Environment’, Disaster management, ‘Sports, Shelter, Women, Disabled, Liberation war, Health, Education, Energy, Minorities, Employee, Product responsibility, IT, Community and Government. The study reveals that the grand mean disclosure of CSR information in annual report of Islamic banks is 25.89% with a standard deviation of 5.49%. Empirical evidence provides that there is statistically significant difference of CSR disclosure among Islamic Sharia-based banking companies in Bangladesh. But there is no significant difference of CSR disclosure of Islamic banking industry in Bangladesh year to year. Moreover, CSR disclosure of Islamic Shari-based banking companies is not diversified rather concentrated on some specific dimension and items of CSR. The study is mainly based on annual reports for the financial year 2011-2015 of Islamic Sharia-based banking companies in Bangladesh. Hence, the conclusion reached cannot be generalized.