bluuebunny/crossref_metadata_2025_split huggingface dataset:
The tunnel approach versus medial approach in laparoscopic radical right hemicolectomy for colon cancer: A retrospective cohort study
Authors: Zhao Yuzhou , zhang xijie , Zhang Junli , Ma Pengfei , Cao Yanghui , Liu Chenyu , Li Sen , Han Guangsen 
Published: April 2020

Abstract

Background: Although Multiple studies showed that the median approach is nowadays the most widely accepted approach according to the “no-touch” principle and safety. However, this approach is a demanding procedure with a steep learning curve and has a high rate of conversion to laparotomy. This aim is to explore the feasibility and safety of tunnel approach in laparoscopic radical right hemicolectomy for colon cancer.Methods：From July 2016 to October 2018, a total of 106 consecutive patients with colon cancer who were subjected to the laparoscopic radical right hemicolectomy in the affiliated cancer hospital of zhengzhou university were enrolled. The patients underwent either tunnel approach (TA) (n=56) or traditional medial approach (MA) (n=50) according to the surgical maneuver performed. The patients' baseline demographics and perioperative results were compared between the two groups.Results: The baseline characteristics did not differ between groups. The blood loss was significantly less [20.0(5.0-40.0) vs. 100(50.0-150.0) , p < 0.001] and operation time was significantly shorter [128.4±16.7 vs. 145.6±20.3min, p < 0.001]in the TA group than those in MA group. Time to first flatus and postoperative hospital stay were similar [3.0(2.0-4.0) vs. 3.0(3-4.0)d，p=0.329; 10.4±2.6 vs. 10.7±3.0d，p=0.506] in both groups. The conversion to laparotomy and complication rates were similar between the groups(0 vs. 6.0%, p = 0.203; 14.3% vs. 18.0%, p =0.603,respectively). There was no treatment-related death in both groups.Conclusions: The tunnel approach in laparoscopic radical right hemicolectomy for colon cancer is a technically feasible and safe procedure as a preferable approach at present compared to those of medial approach, meanwhile this method is easier for beginners to master. Hence this tunnel approach right hemicolectomy is worth recommended.
CT differentiation of gastric ectopic pancreas from gastric stromal tumors
Authors: Wang Jian , LIU Chang , Yang Fang , Zhang Wenming , Ao Weiqun , An Yongyu , Zhang Cui , Dai Bailing , Pu Cailing 
Published: April 2020

Abstract

BackgroundGastric ectopic pancreas (GEPs) is a rare developmental anomaly which is difficult to differentiate it from submucosal tumor such as gastrointestinal stromal tumor (GIST) by imaging methods. So we retrospectively investigated the CT features of them to help us make the correct diagnosis.Materials and MethodsThis study enrolled 17 GEPs and 119 GSTs, which were proven pathologically. We assessed clinical and CT features to identify significant differential features of GEPs from GSTs using univariate and multivariate analyses.ResultsIn univariate analysis, among all clinicoradiologic features, features of age, symptom, tumor marker, location, contour, blurred serosa or fat-line of peritumor, necrosis, calcification, CT attenuation value of unenhancement phase/arterial phase/portal venous phase (CTu/CTa/CTp), the CT attenuation value of arterial phase/portal venous phase minus that of unenhanced phase (DEAP/DEPP), long diameter (LD), short diameter (SD) were considered statistically significant for the differentiation of them. And the multivariate analysis revealed that location, blurred serosa or fat-line of peritumor, necrosis and DEPP were independent factors affecting the identification of them.What's more, ROC analysis showed that the test efficiency of CTp was perfect(AUC= 0.900).ConclusionLocation, blurred serosa or fat-line of peritumor, necrosis and DEPP are useful CT differentiators of GEPs from GSTs. In addition, the test efficiency of CTp in differentiating them was perfect (AUC=0.900).
MeToo movement and sexual violence in women: A qualitative study from Zambia
Authors: Muzyamba Choolwe Mphanza 
Published: April 2020

Abstract

BackgroundDespite the dominance of the #MeToo movement in the fight against sexual violence around the world, the experiences of most vulnerable women in countries like Zambia have been generally ignored in literature. Little is known about how useful this movement is to these women. Thus the aim of this study is to fill this gap by investigating the usefulness of the #MeToo movement as a tool for handling sexual violence among women in Zambia.MethodsThe study makes use of Focus Group Discussion. It involves a sample size of 80 participants. All participants had indicated that they had suffered sexual violence at least once in their lifetime. In the recruitment process, we ensured diversity in terms of age, marital status, employment status, ethnicity, and religious affiliation. Data was analyzed using thematic analysis.ResultsThere is no doubt that the MeToo movement is a useful catalysts for highlighting the severity of sexual violence and creating opportunities of redress in Zambia. However, currently its adoption and implementation seems to be blind to the ways privilege and subordination interact with race, gender, class, and other characteristics to sustain sexual violence. The movement also seems to pay little attention to the various ways the problematic patriarchal norms in Zambia are interwoven with women’s economic survival strategies.ConclusionOur findings suggest that rather than definitively establishing the MeToo movement as an incontestable good (as has been the case in most feminist literature) or as useless because it ignores economic and cultural realities as argued by its critics our findings instead demonstrate the diversity of how this movement is locally viewed by marginalized women in Zambia and also illustrates the nuance, complexity and multidimensionality of how the movement is characterized. In this regard, our findings speak to the folly of a ‘one-size-fits-all’ standardized universalization of the MeToo movement.
Efficacy of Artemisinin-lumefantrine for the treatment of uncomplicated malaria after more than a decade of its use in Kenya
Authors: Kishoyian Gabriel M. , Njagi Eliud N. M. , Orinda George O. , Kimani Francis T. , Thiongo Kevin , Matoke-Muhia Damaris 
Published: April 2020

Abstract
Background: Plasmodium falciparum resistance to antimalarial drugs remains to be a major threat to the control of malaria globally. After the deployment of artemisinin-based combination therapy (ACT), there have been reports of reduced sensitivity of the drug to parasite clearance. In Kenya, artemisinin-lumefantrine (AL) is the recommended first-line drug in the treatment of uncomplicated malaria. This study sought to assess the efficacy of AL after its reintroduction in Kenya, a decade later. In this study, we assessed clinical and parasitological responses of children under five years in May and November 2015 in Chulaimbo sub-County, Kisumu, Kenya.Method: Patients of ≥6 and ≤60 months of age with confirmed Plasmodium falciparum mono-infection were enrolled in the study. The patients were treated with a standard dose of AL and followed up for 28 days. During which period we monitored treatment responses and follow-up adherence.Results: Of the 90 patients enrolled, fourteen (14) were lost to follow-up, with 76 completing the study period. Seventy-five patients 75 (98.7%) cleared, parasitemia within 48 hours while one (1.3%) cleared on day 3. There was 100% clinical and parasitological parasite clearance. Conclusion: Artemisinin lumefantrine was found to be highly efficacious to plasmodium falciparum parasites in children aged ≥6 and ≤60 months. Based on this, the drug can be used to treat uncomplicated malaria in the study population. However, there is need for continued monitoring of its effectiveness in children and adults to counter the threat of resistance.
Large-Scale Metadata Analysis of Ovary Based Multi-Omics Datasets for Understanding the Genes Regulating Litter Size
Authors: Kameshwar Ayyappa Kumar Sista , Li Julang 
Published: April 2020

Abstract

Background : Litter size is a very important production index in the livestock industry, which is controlled by various complex physiological processes. To understand and reveal the common gene expression patterns involved in controlling prolificacy, we have performed a large-scale metadata analysis of five genome-wide transcriptome datasets of pig and sheep ovary samples obtained from high and low litter groups, respectively. We analyzed separately each transcriptome dataset using GeneSpring v14.8 software by implementing standard, generic analysis pipelines and further compared the list of most significant and differentially expressed genes obtained from each dataset to identify genes that are found to be common and significant across all the studies. Results : We have observed a total of 62 differentially expressed genes common among more than two gene expression datasets. The KEGG pathway analysis of most significant genes has shown that they are involved in metabolism, the biosynthesis of lipids, cholesterol and steroid hormones, immune system, cell growth and death, cancer-related pathways and signal transduction pathways. Of these 62 genes, we further narrowed the list to the 25 most significant genes by focusing on the ones with fold change >1.5 and p<0.05. These genes are CYP11A1, HSD17B2, STAR, SCARB1, IGSF8, MSMB, SERPINA1 , FAM46C, HEXA, PTTG1, TIMP1, FAM167B, CCNG1, FAXDC2, HMGCS1, L2HGDH, Lipin1, MME, MSMO1, PARM1, PTGFR, SLC22A4, SLC35F5, CCNA2, CENPU, CEP55, RASSF2, and SLC16A3 . Conclusions : Interestingly, comparing the list of genes with the list of genes obtained from our literature search analysis, we found only three genes in common. These genes are HEXA, PTTG1, and TIMP1. Our finding points to the potential of a few genes that may be important for ovarian follicular development and oocyte quality. Future studies revealing the function of these genes will further our understanding of how litter size is controlled in the ovary while also providing insight on genetic selection of high litter gilts.
Comparison of cyclopentolate versus tropicamide on corneal topography in emmetropic and myopic eyes
Authors: Sharif Nasrin Moghadas , Moghadam Hadi Ostadi , Azizi Elham , Ghoochani Elahe , Ehsaei Asieh 
Published: April 2020

Abstract
Background: To compare the effect of cyclopentolate versus tropicamide eye drops on anterior surface corneal parameters using Keratograph 4 in myopic and emmetropic individuals.Methods: Fifty-eight participants included 29 emmetropic and 29 myopic individuals, were recruited, according to inclusion and exclusion criteria. At baseline visit, anterior surface corneal parameters were measured using Keratograph 4 Keratograph 4in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of tropicamide 1% and cyclopentolate 1% at similar conditions.Results: Of 58 participants who completed the study, 29 (24 women, 5 men, age: 23.82± 2.78 years) were emmetropic and 29 (21women, 8 men, age: 23.66± 2.76 years) were myopic. Baseline mean spherical equivalents were -0.23±0.23 D and -2.45±1.03 D in emmetropic and myopic groups, respectively. The analysis of the data showed a significant hyperopic shift following instillation of both cycloplegic eye drops in both refractive groups. However, tropicamide results was statistically insignificant in comparison with cyclopentolate (p=0.49). The assessment of data revealed no statistically significant differences in anterior surface corneal parameters in baseline, tropicamide and cyclopentolate instillation in each refractive group, except IHD value with tropicamide in myopic group (p=0.02). The further analysis between refractive groups also showed no significant differences in anterior surface corneal parameters in each session.Conclusions: Present study indicates that cyclopentolate and tropicamide do not appear to affect corneal topographic parameters and hence can be trusted to capture topography data.
Using triangular marks of capsulotomy edge for the alignment of Toric IOLs postoperation: a new technique
Authors: Wang Yong , Xue Ying , Li Panpan , Wu Jian , Guan Huaijin 
Published: April 2020

Abstract
Background: Accurate alignment of Toric intraocular lens (IOL) axis is vital for achieving the desired astigmatic correction after surgery. We used a pair of triangular incision markers on anterior capsulotomy edge to assess the rotations of Toric IOL axis and compare with conventional manual corneal marker for postoperative follow-up.Methods: Thirty-six cataract patients (39 eyes) were enrolled who underwent phacoemulsification and AcrySof Toric IOL implantation between May 2018 and August 2018. All patients coexist regular corneal astigmatism between 1.0 diopter(D) and 3.0D. The patients were divided to two groups according to the axial length. Axial length less than 26mm was named Group A. The other patients belong to Group B. Triangular incisions of anterior capsulotomy edge and conventional manual corneal marking method were used to measure the rotations of Toric IOL at 1 and 3 months after surgery.Results: The angels of rotation for Toric IOL assessed by the new markers were less at 1 and 3 months for group A when compared with the conventional manual corneal marking but not for group B. There are not any intraoperative and postoperative complications by using the new technique.Conclusion: The triangular markers in anterior capsulotomy edge are more accurate when compared with conventional manual corneal marking method to evaluate the rotation stability of Toric IOL after operation.
Text Mining and Predicting Disease-Gene-Drug Associations of Hypertension Data Cubes-Based
Authors: Wei Xing , Chang Xuelian , Wang Yanqiu , Xie Jing , Yang Xiaodi , Jiang Xiulin 
Published: April 2020

Abstract
Background Predispositions to hypertension is possibly associated with numerous potential gene polymorphisms and systemic disorders. Large-scale text mining of biomedical literature is a flexible and essential tool that can be applied to search for innovative drugs and treatments for diseases, such as investigating and predicting the bio-entities associations.Result We proposed a generality approach for extracting and predicting hypertension-related disease-gene-drug associations based on dictionary and data cube from biomedical abstracts. After data preprocessing, we constructed the 0-D vertex cube, which we then filtered to construct three 1-D cubes consisting of 252 diseases, 185 genes, and 141 drugs. By applying association rules to quantify the disease-gene-drug associations, we found 235 associations between 79 diseases and the 71 genes, and AUCs was 84.1%; 196 associations between 43 diseases and 102 drugs, and AUCs was 85.8%; 160 associations between 31 genes and 106 drugs, and AUCs was 83.6%. Using the bottom-up computation algorithm, we established three 2-D cubes and one 3-D disease-gene-drug cube, which revealed 591 associations between 90 diseases, 82 genes, and 145 drugs. Based on this 3-D cube, we obtained 262 predictive bio-entity association pairs of which 57 disease-drugs, 84 disease-genes, and 121 gene-drugs.Conclusions We have implemented and validated a data cube-based text mining approach to identifying and ranking the hypertension-related disease-gene-drug associations. Our results provide new pathways in the search for the potential treatment drugs of hypertension.
Coverage Rate of ADME Genes: Application to CYP2C8, CYP2D6 and CYP3A Genes for Personalized Chloroquine Treatment Against Coronavirus
Authors: Zaid Nabil , Khalki Loubna , Hadri Imane , Toughza Jihane , Badad Oussama , Sadki Khalid , Cheikh Amine , Limami Youness , Zaid Younes 
Published: April 2020

Abstract
Background: The latest studies have shown the effectiveness of Chloroquine against Coronavirus. However, since the tolerance and effectiveness of statistical data must be taken into account before proposing treatment to a patient, these promising results are often lacking.Since the CYP2C8, CYP2D6 and CYP3A Absorption, Distribution, Metabolism and Elimination (ADME) genes are involved in the drug response of Chloroquine, we are interested in studying the variations of these genes.Methods: The purpose of this study is to make a comparison between the various current genotyping and enrichment platforms, to know which of them allows the best coverage. Conclusions: This will allow us to carry out genome-wide association studies (GWAS) with the aim of finding new therapeutic targets against Coronavirus using Chloroquine.
Incidence rate and basic reproduction number of Coronavirus diseases (COVID-19): a systematic review and meta-analysis protocol
Authors: Gesesew Hailay Abrha , Mude William , Nyanhanda Tafadzwa , Mwanri Lillian 
Published: April 2020

Abstract
Background : World Health Organization declared Coronavirus (COVID-19) as a newly emerging disease on 31 December 2019. In a space of two-months, there have been several studies reporting incidence rates, incubation periods, fatality rates, basic and effective reproduction numbers of the disease. However, the data have not been synthesized and pooled together to determine the global average. Objective : The present study aims to systematically review available global evidence on incidence rates, and basic and effective reproduction numbers of COVID-19. Methods : This is a protocol for a systematic review of available quantitative studies published in English. Studies which describe the incidence rates, and basic and effective reproduction numbers of COVID-19 will be included in the search. Initially, search term concepts will be constructed through a preliminary search on Google scholar. Then, we will perform a full systematic search using the identified concepts in the following electronic bibliographic databases: SCOPUS, PubMed, Web of Sciences and CINAHL. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) will be used to schematically present the full search strategy. Standardised Joanna Briggs Institute (JBI) quality appraisal and selection tools, and data extraction tools will be used to recruit studies and extract data from the included studies, respectively. Thematic analysis will be used to analyse the non-quantifiable data, and meta-analysis will be used to pool the quantitative information.
Prenatal diagnosis of fetal chromosomal abnormalities among 2318 pregnant women with indications in southern China: a retrospective study
Authors: Gu Xiaodong , Liu Sudong , Wang Huaxian , Weng Ruiqiang , Guo Xuemin , Zhong Zhixiong 
Published: April 2020

Abstract
Background

To investigate the frequency of fetal chromosomal abnormalities among women with abnormal ultrasound, abnormal biochemical marker screening or noninvasive prenatal testing results, advanced maternal age, or history of miscarriage in southern China.
Methods

We retrospectively analyzed prenatal samples from pregnant women between 2015 and 2019. Conventional karyotyping was performed using GTG banding. Copy number variation sequencing was used when indicated to identify chromosomal abnormalities.
Results

A total of 2,318 prenatal samples (188 chorionic villus samples, 2,003 amniotic fluids, and 127 cord blood) were analyzed. The frequency of chromosomal abnormalities was 12.4% (288/2,318) in prenatal samples, and frequency in chorionic villus samples (23.9%) was higher than in amniotic fluids (13.5%) and in cord blood (5.0%; P < 0.001). Numerical anomalies were detected in 195 (8.4%) cases and the most common abnormality were trisomy 21 (103/2,318; 4.4%), trisomy 18 (31/2,318; 1.3%) and monosomy X (18/2,318; 0.8%). Sructural anomalies were found in 29 (1.3%) cases, rare anomalies such as deletions (4 cases), duplications (2 cases), and complex rearrangement (1 case), were detected. Two cases with common chromosomal polymorphisms, inv(9)(p11q12) and inv(9)(p11q13), associated with recurrent spontaneous abortion, were detected. Five fetuses had normal karyotypes and definite pathogenic copy number variations, with microdeletions at 16p13.11, 16p12.1 (2 cases), and 17p12 and a microduplication at 7q11.23; all had normal phenotypes after birth.
Conclusion

Our study indicated that fetal chromosomal anomalies can be detected in early gestation and provided valuable information for interpretation of chromosomal polymorphisms and copy number variations.
Identification of TFEB gene genetic variants in acute myocardial infarction
Authors: Zhang Jie , Zhang Yexin , He Xiaohui , Wang Shuai , Pang Shuchao , Yan Bo 
Published: April 2020

Abstract
Background: Abnormal lipid metabolism and inflammation play critical roles in the initiation and progression of atherosclerosis and its associated complications, including coronary artery disease (CAD) and acute myocardial infarction (AMI). Autophagic-lysosomal system is involved in many physiological processes, such as lipid metabolism and inflammation. TFEB, a master regulator of the system, coordinates the expression of lysosomal hydrolases, lysosomal membrane proteins, and autophagic proteins. Altered level of TFEB gene expression and subsequent changes of autophagic-lysosomal system may be involved in the onset of CAD and AMI.Methods: In this study, the promoter of the TFEB gene was genetically and functionally analyzed in AMI patients (n=352) and ethnic-matched healthy controls (n=337).Results: A total of fifteen genetic variants, including eight single nucleotide polymorphisms (SNPs), were identified in the participants. Two novel genetic variants and four SNPs were only identified in six AMI patients, and significantly altered the transcriptional activity of the TFEB gene in cultured cells. Further electrophoretic mobility shift assay revealed that two genetic variants (g.41737144A>G and g.41736544C>T) and two SNPs [g.41737274T>C (rs533895008) and g.41736987C>T (rs760293138)] evidently affected the binding of transcription factors.Conclusions: Our findings suggested that the genetic variants in TFEB gene promoter may change TFEB levels, contributing to AMI as a low-frequency risk factor.
Effectiveness of No-Zone Approach for Management of Isolated Penetrating Neck Injuries Among Hemodynamically Stable Patients. A Longitudinal Retrospective Study.
Authors: Hassanein Ahmed Gaber , Elmoshneb Mohammed Hazem , Ahmad Wael A. , Aldardeer Ahmed Abdel Kahaar , Ismail Osama A. 
Published: April 2020

Abstract
Background: Routine neck exploration for isolated penetrating neck injuries (PNIs) in hemodynamically stable patients increases the frequency of nontherapeutic surgeries, and complications. Current management protocol involves the no zone approach which uses physical examination and computerized tomographic angiography to guide treatment plans. This work aimed to study the effectiveness and reliability of no-zone approach for management of isolated PNIs in hemodynamically stable patients. Methods: cases of isolated PNIs in hemodynamically stable patients were managed using no zone approach. Detected injuries were managed accordingly. Results: This study included 106 patients. 34.9% of patients were managed conservatively while surgery was done at 65.09%. Vascular management was done in 40.57%, laryngotracheal repair in 29.2%, tracheostomy in 17%, pharyngeal repair in 7.55%, esophageal repair in 6.6%, and accessory nerve repair in 2.83%. Complications occurred in 16.04% of cases in the form of vascular complications (7.5%), respiratory complications (5.7%), pharyngoesophageal complications (1.9%), infections (12.3%), and neurological complications (7.5%). The survivors were 91.5% while deaths were 8.5%. Conclusion: The no-zone approach offers the ideal management for isolated PNIs in hemodynamically stable patients. It is advantageous over traditional approaches. Further studies are required to augment the evidence for its use as the gold standard management for such cases. Trial registration: the study was retrospectively registered at research registry with Research Registry UIN researchregistry5385 on February 26, 2020. Keywords: no zone approach, isolated penetrating neck injuries, hemodynamically stable patients, vascular injuries, laryngotracheal injury.