bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors impacting prescription practice in primary healthcare setting in India: A case study in Rajasthan
Authors: Das Arup Kumar , Nagarajan Shyama , Bhargava Ruchi , Singh Rajesh Ranjan , Srivastava Ambey Kumar , Dutta Amitabh 
Published: June 2020

A.AbstractBackgroundWe present a case of prescription practices in the Indian state of Rajasthan to demonstrate the effect of provider and system level factors, and their interactions on good prescription practices. We have presented two major dimensions of good prescription practice; first, completeness of prescription, a measure of adequacy; and second, appropriateness of prescription, a measure of quality of care (QoC).MethodWe used mixed method to audit 2801 prescriptions, selected from 24 rural and 7 urban government Primary Health Centres (PHCs) of Rajasthan, India. The findings represent analysis of 97% of the ‘selected prescriptions’ that were considered ‘legible’. The ‘selected prescriptions’ ensure represent variance in patient categories, seasonality and number of OPD foot fall across days in a week. Semi-structured in-depth interviews, followed by Focused Group Discussion (FGD) with providers was undertaken to obtain insights about facilitators and barriers to good prescription practices. We compared descriptive statistics across quintiles on adequacy indicators to understand variations around provider and system level factors; multilevel logistic regression model was used to obtain the adjusted effect. To assess appropriateness of quality of care (QoC), we evaluated 783 prescriptions that had adequate information to compare factors impacting QoC across quintiles. Finally, findings from the FGD was used to substantiate findings from the quantitative analysis.ResultWe found that prescription practices are outcomes of both provider and system level factors, and their interactions. The documentation of patient complaint, examination findings largely depends on system level factors; 59% and 38%, respectively. The treatment adequacy is largely associated with patient category. Ownership compliance of the doctors, measured in terms of their signature in the prescriptions, emerged as an important factor determining both adequacy and accuracy of prescriptions. We also found that treatment appropriateness, measured in terms of QoC, depends on both provider and system level factors. A conducive environment and trained provider are more likely to provide adequate and appropriate treatment. It is also observed that higher patient load is not a counter-productive to treatment appropriateness. Out of 783 legible prescriptions that were assessed for its appropriateness, only 36% were found inappropriate in terms of their documented justification for the treatment advised.ConclusionThere is a need to focus on provider and system level factors to improve prescription practices in primary health care (PHC). We recommend that institutional strengthening at systemic and provider level using innovative ways; such as task shifting to nurses as ‘physician assistants’, and reducing administrative activities of physicians to enhance focus on clinical work can propel better prescription practice.
Dual decision-making with discontinuance and acceptance of information technology: the case of cloud computing
Authors: Bian Yiyang , Kang Lele , Zhao J. Leon 
Published: June 2020

PurposeThe purpose of this paper is to investigate organizational information technology (IT) deployment from a dual decision-making perspective. This study builds on rational choice theory to characterize how the costs and values of incumbent IT and those of the corresponding new cloud computing influence a company's dual decision of discontinuance and acceptance.Design/methodology/approachThis study chooses cloud computing as the research context, since it is one of the most well-accepted ITs in current practice. By using survey methodology, the data were collected from organizations around the world. Our hypotheses were examined via multimethod analyses, including the partial least squares, the multinomial log it regression and the analysis of variance.FindingsThis research reveals that organizations often follow the dual decision-making process in IT deployment regarding a non-cloud, hybrid structure and full-cloud considers incumbent IT discontinuance and new cloud computing acceptance. These results indicate that organizations may embrace cloud computing because of its perceived high system compatibility and low support costs. Meanwhile, security threats remain the primary obstacles to conducting business in the cloud.Originality/valuePrevious studies mainly focus on a single aspect and do not reveal the intricacies of the interactions between the reduction of incumbent IT and the addition of new IT. To address this gap in the body of knowledge, our study proposes a dual decision model based on a dialectical understanding of new and incumbent IT mechanisms instead of a singular IT acceptance model.
Dude, where's my data? The GDPR in practice, from a consumer's point of view
Authors: Sørum Hanne , Presthus Wanda 
Published: June 2020

PurposeThis paper investigates the European Union's General Data Protection Regulation (GDPR) in information systems (ISs). The GDPR consists of 99 articles, and two articles are emphasised – namely Article 15, which deals with rights of access by the data subject, and Article 20, which deals with the right to data portability.Design/methodology/approach15 companies operating in the Norwegian consumer market were randomly selected. Each company received an inquiry pertaining to rights of access by the data subject (Article 15) and the right to data portability (Article 20). The research team carefully analysed the answers received and categorised the responses according to the two articles emphasised.FindingsThe findings show extensive variations among the companies in terms of response time, quality of feedback and how companies handle requests concerning rights of access by the data subject (Article 15) and the right to data portability (Article 20). Differences are also pertaining to the types of files, along with the content of these files. It should be noted, however, that most of the companies replied to the inquiry before the deadline. The findings show that companies comply better with Article 20 than Article 15. However, it appears that they do not differentiate between the two articles.Originality/valueThis study explores a research topic that is relatively new. It addresses a gap in the extant research by highlighting how the GDPR works in practice from a consumer's perspective. In addition, guidelines are offered to the consumers and companies affected by the GDPR.
Are share prices of Gulf corporate council banks predictable? A time-series analysis
Authors: Almujamed Hesham I. 
Published: June 2020

PurposeThis research aimed to evaluate the predictability of moving-average strategies and examined the validity of the weak form of the efficient market hypothesis (EMH) for securities of banks listed in the Gulf Cooperation Council (GCC) stock markets of Bahrain, Kuwait, Qatar and Saudi Arabia.Design/methodology/approachSeveral statistical analyses and eight moving-average rules were employed where buy and sell signals were produced by comparing a security price’s short- and long-term moving averages. The study covered the daily closing share prices of 40 GCC-listed banks over the 18-year period ending 31 December 2017.FindingsThe results suggest that securities of banks in the GCC were not weak-form efficient because share prices were predictable. Investors who traded using moving-average strategies could generate higher profits. Analysis of variance found that securities of Kuwaiti banks were the most efficiently priced.Practical implicationsThe findings supported the idea that profitability depended on the moving-average rules and country chosen. Transaction costs did not affect the returns obtained using different trading rules.Originality/valueThis work facilitates future evaluation of accounting disclosure environments as well as the market efficiency and the performance of securities in the GCC countries. The performance of moving average rules among representative countries that share similar characteristics was analyzed. Different market participants, including investors, analysts and regulators, can benefit from this study for decision-making. These results suggest that new regulations might be drafted that would improve the timeliness of accounting information and the banks’ level of efficiency.
Creating for others: linking prosocial motivation and social entrepreneurship intentions
Authors: Yu Chuanpeng , Ye Baosheng , Ma Shenghui 
Published: June 2020

PurposeThe purpose of this study is to investigate how individuals' prosocial motivation affects their social entrepreneurship intentions (SEI) through the mediating effect of creativity and the moderating effect of family-to-work support.Design/methodology/approachA questionnaire survey was conducted in the Pearl River Delta region in Guangdong, China, and data were collected from 318 respondents who had rich social work experience. To test the hypotheses, a hierarchical linear regression analysis was conducted using SPSS 24.0 software.FindingsResults offer empirical support for the hypotheses that creativity in social work plays a full mediating role in the relationship between individuals' prosocial motivation and SEI, and family-to-work support plays a positive moderating role in the relationship between creativity in social work and SEI.Research limitations/implicationsThis study shows the importance of prosocial motivation, creativity in social work and family support in driving individuals' social entrepreneurship intentions and behaviours. Future research needs to further examine how the dynamic relationships between these factors unfold over time, as well as consider the effect of other motivational factors on creativity and SEI.Practical implicationsThis study suggests that the cultivation of individual prosocial motivation is crucial and requires the efforts of family, school and society. Relevant organisations should encourage individuals to incorporate creative thinking into their work, as well as offer training opportunities. In addition, social entrepreneurs should also strengthen communication with their families and strive to gain their understanding and support.Originality/valueThe findings of this study extend existing views on the relationship between individuals' motivation and entrepreneurship intentions in the social entrepreneurship research field by focusing on the perspective of prosocial motivation. In particular, this study reveals the complex process of how prosocial motivation promotes SEI by identifying the role of creativity and family-to-work support, which has rarely been explored in the extant literature.
Marketing of environmentally friendly hotels in China through religious segmentation: a theory of planned behaviour approach
Authors: Wang Lei , Wong Philip Pong Weng 
Published: June 2020

PurposeThe purpose of this study is to examine the relationship between religiosity, green purchase attitude (GPA), subjective norm (SN), perceived behavioural control (PBC) and green purchase intention (GPI) towards the selection of environmentally friendly hotel. The current study argues that consumers’ incentive variable, namely, religiosity, can influence consumers’ environmentally friendly hotel selection.Design/methodology/approachThis study had successfully gathered 404 completed questionnaire sets through online surveys. All survey data were subjected to descriptive analysis and analysis of variance using SPSS. Besides that, confirmatory factor analysis and structural equation modelling were performed for the testing of hypotheses.FindingsThe results suggest that religiosity significantly and positively influences GPA, SN, PBC and GPI. Furthermore, GPA and PBC positively and significantly influence GPI. The SN also displays significant positive influence on GPA, while GPA plays a full mediation role between SN and GPI. In addition, statistically significant differences in religiosity, SN and PBC were obtained between religious affiliations of consumers towards environmentally friendly hotel selection.Originality/valueThis study extended the existing knowledge based on the selection of environmentally friendly hotels among religious consumers in the tourism literature. Besides that, these empirical findings would greatly benefit hotel managers and other key stakeholders in the tourism industry.
Characterization of gene expression profiles of esophageal cancer patients with different nonsynonymous tumor mutation burden
Authors: Li Jiawei , Chen Haiqing , Guo Haifa , Qiu Mantang , Yang Fan 
Published: June 2020

BackgroundNonsynonymous tumor mutation burden (NSTMB) could affect the prognosis of esophageal cancer (EC) patients, but differentially expressed genes between EC patients with different NSTMB have not been explored. Our study aimed to compare differentially expressed genes between EC patients with different NSTMB (high vs. low).MethodsRNA‐seq data for EC patients were downloaded from The Cancer Genome Atlas (TCGA). The edgeR package was used to identify differentially expressed genes between patients with different NSTMB. Cell type identification by estimating relative subsets of known RNA transcripts (CIBERSORT) software was employed to underscore immune cell differences between patients with different NSTMB.ResultsIn total, we discovered 2215 differentially expressed genes between patients with different NSTMB, among which 842 genes were upregulated and 1373 downregulated in patients with high NSTMB. The differentially expressed genes were enriched in pathways such as heme binding and structural molecule activity. We built a logistic model that may be used to predict patients' NSTMB. We found that tumors with high NSTMB had a significantly higher percentage of resting natural killer (NK) cells than those with low NSTMB (P = 0.028). The percentages of regulatory T (Treg) and CD8+ T cells were also higher in those with high NSTMB, although it was not statistically significant (P = 0.064 for Treg cells and P = 0.12 for CD8+ T cells).ConclusionsNSTMB may cause changes in gene expression and immune cell infiltration in EC patients, and affect the overall survival of EC patients.Key pointsSignificant findings of the study
This study found differentially expressed genes and differences in infiltration of immune cells between esophageal cancer (EC) with different NSTMB.
What this study adds
This study highlights differences between EC patients with different NSTMB.
Transcriptome‐Wide Regulation of Key Developmental Pathways in the Mouse Neural Tube by Prenatal Alcohol Exposure
Authors: Boschen Karen E. , Ptacek Travis S. , Simon Jeremy M. , Parnell Scott E. 
Published: June 2020

BackgroundEarly gestational alcohol exposure is associated with severe craniofacial and CNS dysmorphologies and behavioral abnormalities during adolescence and adulthood. Alcohol exposure during the formation of the neural tube (gestational day [GD] 8 to 10 in mice; equivalent to4th week of human pregnancy) disrupts development of ventral midline brain structures such as the pituitary, septum, and ventricles. This study identifies transcriptomic changes in the rostroventral neural tube (RVNT), the region of the neural tube that gives rise to the midline structures sensitive to alcohol exposure during neurulation.MethodsFemale C57BL/6J mice were administered 2 doses of alcohol (2.9 g/kg) or vehicle 4 hours apart on GD 9.0. The RVNTs of embryos were collected 6 or 24 hours after the first dose and processed for RNA‐seq.ResultsSix hours following GD 9.0 alcohol exposure (GD 9.25), over 2,300 genes in the RVNT were determined to be differentially regulated by alcohol. Enrichment analysis determined that PAE affected pathways related to cell proliferation, p53 signaling, ribosome biogenesis, and immune activation. In addition, over 100 genes involved in primary cilia formation and function and regulation of morphogenic pathways were altered 6 hours after alcohol exposure. The changes to gene expression were largely transient, as only 91 genes identified as differentially regulated by prenatal alcohol at GD 10 (24 hours postexposure). Functionally, the differentially regulated genes at GD 10 were related to organogenesis and cell migration.ConclusionsThese data give a comprehensive view of the changing landscape of the embryonic transcriptome networks in regions of the neural tube that give rise to brain structures impacted by a neurulation‐stage alcohol exposure. Identification of gene networks dysregulated by alcohol will help elucidate the pathogenic mechanisms of alcohol’s actions.
Intraguild predation and cannibalism among Dicyphini: Dicyphus cerastii vs. two commercialized species
Authors: Abraços Duarte Gonçalo , Caldas Filipa , Pechirra Ariadna , Borges da Silva Elsa , Figueiredo Elisabete 
Published: June 2020

AbstractDicyphine mirids are one of the most important groups of predators on tomato. In the Mediterranean region, several species in the genera Dicyphus, Macrolophus, and Nesidiocoris (Hemiptera: Miridae, Bryocorinae, Dicyphini) colonize protected horticultural crops. In Portugal, Nesidiocoris tenuis (Reuter) is increasingly abundant in the mirid species complex of tomato crops and appears to be displacing the native Dicyphus cerastii Wagner. In order to know whether intraguild predation (IGP) can explain the decreasing abundance of D. cerastii, we evaluated predatory interactions between adult females and first instars of D. cerastii vs. N. tenuis but also D. cerastii vs. Macrolophus pygmaeus (Rambur), as this species is also naturally present in horticultural crops in Portugal. Cannibalistic interactions were also tested for the same three species. All experiments were performed under laboratory conditions, in Petri dish arenas, in the presence or absence of Ephestia kuehniella Zeller (Lepidoptera: Pyralidae) eggs as alternative prey. Predation on both heterospecific and conspecific nymphs occurred only in the absence of alternative food. Intraguild predation was mutual and symmetrical between D. cerastii and M. pygmaeus. However, IGP was asymmetrical between D. cerastii and N. tenuis, favouring the first. Cannibalism was not significantly different among these mirid species. Our results show that D. cerastii has a greater capacity to feed on intraguild prey than N. tenuis. Therefore, IGP on small nymphs does not explain the abundance shift between D. cerastii and N. tenuis.
Whole‐body clearing of beetles by successive treatment with hydrogen peroxide and CUBIC reagents
Authors: Kuroda Monto , Kuroda Shinya 
Published: June 2020

AbstractInternal tissues of multicellular organisms cannot directly be seen because they contain pigments. For this reason, whole‐body clearing methods have been developed and applied to mammals such as mice. Insects such as beetles, however, cannot be cleared by the mammalian method because of pigments such as melanin in their exoskeletons. In this study, we tried to develop a whole‐body clearing method for large beetles. We first bleached the exoskeleton using a hydrogen peroxide treatment, and applied advanced Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis (CUBIC) reagents to make the internal tissues transparent. The combined method of hydrogen peroxide and advanced CUBIC allowed us to successfully undertake whole‐body clearing of large beetles.
GEP‐based classifiers with drift‐detection
Authors: Jedrzejowicz Joanna , Jedrzejowicz Piotr 
Published: June 2020

AbstractIn the paper, we propose two gene expression programming (GEP)‐based ensemble classifiers with different drift detection mechanisms. In the related work section, we briefly review GEP as a classification tool, incremental classifiers, and concept drift detectors. Next, the structure of our two‐level GEP ensemble with metagenes is described. Further on, two integrated classifiers with drift detection algorithm and Wilcoxon rank sum test drift detector are proposed. The approach is validated in the computational experiment in which several real‐life and artificial datasets with concept drift have been used. Experiment confirmed that the proposed approach can be competitive to existing solutions. In the conclusion section, we briefly outline directions for future research.
Effect of three or more treatments with lusutrombopag in patients with cirrhotic thrombocytopenia: A retrospective single‐center study
Authors: Kawaratani Hideto , Tsuji Yuki , Ishida Koji , Kaya Daisuke , Kubo Takuya , Fujinaga Yukihisa , Sawada Yasuhiko , Sato Shinya , Takaya Hiroaki , Kaji Kosuke , Namisaki Tadashi , Moriya Kei , Akahane Takemi , Yoshiji Hitoshi 
Published: June 2020

AimsThrombocytopenia is a common complication among patients with chronic liver disease (CLD). Lusutrombopag, an oral thrombopoietin receptor agonist, is used to reduce the risk of hemorrhage in patients with thrombocytopenia who are undergoing invasive procedures. Platelet transfusion was the standard treatment for thrombocytopenia; however, multiple platelet transfusions lead to the production of antiplatelet antibody. The effect of giving lusutrombopag three times or more has not been previously reported. In this study, we investigated the effect of lusutrombopag readministration in patients with thrombocytopenia.MethodsThis study included 14 patients (total, 24 readministrations) who received lusutrombopag two times or more. Changes in platelet counts were evaluated. Treatment response was defined as an increased platelet count of ≥20 000/μL after lusutrombopag treatment.ResultsLusutrombopag was given twice in nine patients, three times in three patients, five times in one patient, and six times in one patient. An elevated platelet count of <20 000/μL was noted in only one of the 24 readministrations. There were no postoperative hemorrhagic complications, and no patient had an increased platelet count of >200 000/μL. One patient had a portal venous mural thrombus; however, he was asymptomatic, and the thrombus resolved after anticoagulant treatment, without recurrence. The comparison between the first, second, and third or more treatments showed there was no significant difference in platelet increase.ConclusionRepeated treatment of lusutrombopag is effective for CLD patients with thrombocytopenia. Moreover, three or more treatments with lusutrombopag showed equal effect compared with one and two treatments with the medication.
Paraneoplastic erythroderma: an insight on the existing data
Authors: Plachouri Kerasia‐Maria , Georgiou Sophia 
Published: June 2020

AbstractExfoliative erythroderma is a severe dermatologic condition with variable underlying causes. The association of erythroderma with an occult visceral malignancy is a relatively uncommon finding, which, however, can be accompanied by devastating consequences. This report is the first updated overview regarding the latest data on paraneoplastic erythroderma and was conducted according to the PRISMA Guidelines for systematic reviews. Articles derived from the databases PubMed, EMBASE, and SCOPUS were analyzed for this study. Patients with paraneoplastic erythroderma share certain clinical characteristics that physicians should be aware of, so as to avoid potential sequeale of an erroneous management as a result of misdiagnosis. The reporting of such cases is crucial in order to raise awareness of this condition and to facilitate an earlier diagnosis.