bluuebunny/crossref_metadata_2025_split huggingface dataset:
The angular distributions of elastic scattering of 12,13C+Zr *
Authors: Rong Cui-Hua , Zhang Gao-Long , Gan Lin , Li Zhi-Hong , Brandão L. C. , Cardozo E. N. , Cortes M. R. , Li Yun-Ju , Su Jun , Yan Sheng-Quan , Zeng Sheng , Lian Gang , Guo Bing , Wang You-Bao , Liu Wei-Ping , Lubian J. 
Published: August 2020

Abstract
To obtain the neutron spectroscopic amplitudes for 90-96Zr overlaps, experimental data of elastic scattering with small experimental errors and precise optical potentials were analyzed. In this study, the elastic scattering angular distributions of

C +

(A = 90, 91, 92, 94, 96) were measured using the high-precision Q3D magnetic spectrometer in the Tandem accelerator. The São Paulo potential was used for the optical potential. The optical model and coupled channel calculations were compared with the experimental data. The theoretical results were found to be very close to the experimental data. In addition, the possible effects of the couplings to the inelastic channels of the

targets and

C projectiles on the elastic scattering were studied. It was observed that the couplings to the inelastic channels of the

C projectiles could improve the agreement with the experimental data, while the inelastic couplings to the target states are of minor importance. The effect of the one-neutron stripping in the

C+

elastic scattering was also studied. The one-neutron stripping channel in

C +

was found to be not relevant and did not affect the elastic scattering angular distributions. Our results also show that in the reactions with the considered zirconium isotopes, the presence of the extra neutron in

C does not influence the reaction mechanism, which is governed by the collective excitation of the

C core.
Equation of state and chiral transition in soft-wall AdS/QCD with a more realistic gravitational background *
Authors: Fang Zhen , Wu Yue-Liang 
Published: August 2020

Abstract
We construct an improved soft-wall AdS/QCD model with a cubic coupling term of the dilaton and the bulk scalar field. The background fields in this model are solved by the Einstein-dilaton system with a nontrivial dilaton potential, which has been shown to reproduce the equation of state from the lattice QCD with two flavors. The chiral transition behaviors are investigated in the improved soft-wall AdS/QCD model with the solved gravitational background, and the crossover transition can be realized. Our study provides the possibility to address the deconfining and chiral phase transitions simultaneously in the bottom-up holographic framework.
Strain engineering in monolayer WS2 and WS2 nanocomposites
Authors: Wang Fang , Li Suhao , Bissett Mark A , Kinloch Ian A , Li Zheling , Young Robert J 
Published: August 2020

Abstract
There has been a massive growth in the study of transition metal dichalcogenides (TMDs) over the past decade, based upon their interesting and unusual electronic, optical and mechanical properties, such as tuneable and strain-dependent bandgaps. Tungsten disulphide (WS2), as a typical example of TMDs, has considerable potential in applications such as strain engineered devices and the next generation multifunctional polymer nanocomposites. However, controlling the strain, or more practically, monitoring the strain in WS2 and the associated micromechanics have not been so well studied. Both photoluminescence (PL) spectroscopy and Raman spectroscopy have been proved to be effective but PL cannot be employed to characterise multilayer TMDs while it is difficult for Raman spectroscopy to reveal the band structure. In this present study, PL and Raman spectroscopy have been combined to monitor the strain distribution and stress transfer of monolayer WS2 on a flexible polymer substrate and in polymer nanocomposites. It is demonstrated that WS2 still follows continuum mechanics on the microscale and that strain generates a non-uniform bandgap distribution even in a single WS2 flake through a simple strain engineering. It is shown that these flakes could be useful in optoelectronic applications as they become micron-sized PL emitters with a band gap that can be tuned by the application of external strain to the substrate. The analysis of strain distributions using Raman spectroscopy is further extended to thin-film few-layer WS2 polymer nanocomposites where it is demonstrated that the stress can be transferred effectively to WS2 flakes. The relationship between the mechanical behaviour of single monolayer WS2 flakes and that of few-layer flakes in bulk composites is investigated.
Thermal tolerance depends on season, age and body condition in imperilled redside dace Clinostomus elongatus
Authors: Turko Andy J , Nolan Colby B , Balshine Sigal , Scott Graham R , Pitcher Trevor E 
Published: August 2020

AbstractUrbanization tends to increase water temperatures in streams and rivers and is hypothesized to be contributing to declines of many freshwater fishes. However, factors that influence individual variation in thermal tolerance, and how these may change seasonally, are not well understood. To address this knowledge gap, we studied redside dace Clinostomus elongatus, an imperilled stream fish native to rapidly urbanizing areas of eastern North America. In wild redside dace from rural Ohio, USA, acute upper thermal tolerance (i.e. critical thermal maximum, CTmax) ranged between ~34°C in summer (stream temperature ~22°C) and 27°C in winter (stream temperature ~2°C). Juveniles had higher CTmax than adults in spring and summer, but in winter, CTmax was higher in adults. Thermal safety margins (CTmax − ambient water temperature; ~11°C) were less than the increases in peak water temperature predicted for many redside dace streams due to the combined effects of climate change and urbanization. Furthermore, behavioural agitation occurred 5–6°C below CTmax. Safety margins were larger (&gt;20°C) in autumn and winter. In addition, redside dace were more sensitive (2.5°C lower CTmax) than southern redbelly dace Chrosomus erythrogaster, a non-imperilled sympatric cyprinid. Body condition (Fulton’s K) of adult redside dace was positively correlated with CTmax, but in juveniles, this relationship was significant only in one of two summers of experiments. Next, we measured CTmax of captive redside dace fed experimentally manipulated diets. In adults, but not juveniles, CTmax was higher in fish fed a high- vs. low-ration diet, indicating a causal link between nutrition and thermal tolerance. We conclude that redside dace will be challenged by predicted future summer temperatures, especially in urbanized habitats. Thus, habitat restoration that mitigates temperature increases is likely to benefit redside dace. We also suggest habitat restoration that improves food availability may increase thermal tolerance, and thus population resilience.
Categories of systematic influences applied to increase cancer screening participation: a literature review and analysis
Authors: Rahbek Or Joseph , Jauernik Christian P , Ploug Thomas , Brodersen John 
Published: August 2020

AbstractBackgroundHealth authorities can influence citizens in subtle ways that render them more likely to participate in cancer screening programmes, and thereby possibly increase the beneficial effects. If the influences become too severe, the citizens’ ability to make a personal choice may be lost on the way. The purpose of this analysis was to identify and categorize the influences while questioning whether they still permit the citizens to make their own choices regarding participation.MethodsA two-stringed approach was used to obtain empirical examples of systematic influences that aim to raise participation rates in cancer screening programmes: First, a systematic literature search was conducted on three databases. Second, relevant experts were contacted via internationally based e-mail lists and asked for examples of systematic influences in cancer screening. The present analysis was based on direct, conventional content analysis to address different categories of systematic influences.ResultsThe literature search yielded 19 included articles and the expert inquiry yielded 11 empirical examples of which content analysis of the empirical examples generated six major categories of systematic influence: (i) misleading presentation of statistics, (ii) misrepresentation of harms vs. benefits, (iii) opt-out systems, (iv) recommendation of participation, (v) fear appeals and (vi) influencing the general practitioners and other healthcare professionals.ConclusionThe six categories of identified influences work through psychological biases and personal costs and are still in widely use. The use of these types of influence remains ethically questionable in cancer screening programmes since they might compromise informed decision making.
Chronic lymphocytic leukemia (CLL) risk is mediated by multiple enhancer variants within CLL risk loci
Authors: Yan Huihuang , Tian Shulan , Kleinstern Geffen , Wang Zhiquan , Lee Jeong-Heon , Boddicker Nicholas J , Cerhan James R , Kay Neil E , Braggio Esteban , Slager Susan L 
Published: August 2020

Abstract
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. It has a strong genetic basis, showing a ~ 8-fold increased risk of CLL in first-degree relatives. Genome-wide association studies (GWAS) have identified 41 risk variants across 41 loci. However, for a majority of the loci, the functional variants and the mechanisms underlying their causal roles remain undefined. Here, we examined the genetic and epigenetic features associated with 12 index variants, along with any correlated (r2 ≥ 0.5) variants, at the CLL risk loci located outside of gene promoters. Based on publicly available ChIP-seq and chromatin accessibility data as well as our own ChIP-seq data from CLL patients, we identified six candidate functional variants at six loci and at least two candidate functional variants at each of the remaining six loci. The functional variants are predominantly located within enhancers or super-enhancers, including bi-directionally transcribed enhancers, which are often restricted to immune cell types. Furthermore, we found that, at 78% of the functional variants, the alternative alleles altered the transcription factor binding motifs or histone modifications, indicating the involvement of these variants in the change of local chromatin state. Finally, the enhancers carrying functional variants physically interacted with genes enriched in the type I interferon signaling pathway, apoptosis, or TP53 network that are known to play key roles in CLL. These results support the regulatory roles for inherited noncoding variants in the pathogenesis of CLL.
Metabolic stress regulates genome-wide transcription in a PTEN-dependent manner
Authors: Abbas Ata , Padmanabhan Roshan , Eng Charis 
Published: August 2020

AbstractPTEN is implicated in a wide variety of pathophysiological conditions and traditionally studied in the context of the PIK3–AKT–mTOR axis. Recent studies from our group and others have reported a novel role of PTEN in the regulation of transcription at the genome-wide scale. This emerging role of PTEN on global transcriptional regulation is providing a better understanding of various diseases, including cancer. Because cancer progression is an energy-demanding process and PTEN is known to regulate metabolic processes, we sought to understand the role of PTEN in transcriptional regulation under metabolic stress, a condition often developing in the tumor microenvironment. In the present study, we demonstrate that PTEN modulates genome-wide RNA Polymerase II occupancy in cells undergoing glucose deprivation. The glucose-deprived PTEN null cells were found to continue global gene transcription, which may activate a survival mode. However, cells with constitutive PTEN expression slow transcription, an evolutionary mechanism that may save cellular energy and activate programmed cell death pathways, in the absence of glucose. Interestingly, alternative exon usage by PTEN null cells is increased under metabolic stress in contrast to PTEN-expressing cells. Overall, our study demonstrates distinct mechanisms involved in PTEN-dependent genome-wide transcriptional control under metabolic stress. Our findings provide a new insight in understanding tumor pathology and how PTEN loss of function, whether by genetic or non-genetic mechanisms, can contribute to a favorable transcriptional program employed by tumor cells to escape apoptosis, hence developing more aggressive and metastatic phenotypes.
Performance of a high-throughput next-generation sequencing method for analysis of HIV drug resistance and viral load
Authors: Fogel Jessica M , Bonsall David , Cummings Vanessa , Bowden Rory , Golubchik Tanya , de Cesare Mariateresa , Wilson Ethan A , Gamble Theresa , del Rio Carlos , Batey D Scott , Mayer Kenneth H , Farley Jason E , Hughes James P , Remien Robert H , Beyrer Chris , Fraser Christophe , Eshleman Susan H 
Published: August 2020

Abstract

Objectives
To evaluate the performance of a high-throughput research assay for HIV drug resistance testing based on whole genome next-generation sequencing (NGS) that also quantifies HIV viral load.

Methods
Plasma samples (n = 145) were obtained from HIV-positive MSM (HPTN 078). Samples were analysed using clinical assays (the ViroSeq HIV-1 Genotyping System and the Abbott RealTime HIV-1 Viral Load assay) and a research assay based on whole-genome NGS (veSEQ-HIV).

Results
HIV protease and reverse transcriptase sequences (n = 142) and integrase sequences (n = 138) were obtained using ViroSeq. Sequences from all three regions were obtained for 100 (70.4%) of the 142 samples using veSEQ-HIV; results were obtained more frequently for samples with higher viral loads (93.5% for 93 samples with &gt;5000 copies/mL; 50.0% for 26 samples with 1000–5000 copies/mL; 0% for 23 samples with &lt;1000 copies/mL). For samples with results from both methods, drug resistance mutations (DRMs) were detected in 33 samples using ViroSeq and 42 samples using veSEQ-HIV (detection threshold: 5.0%). Overall, 146 major DRMs were detected; 107 were detected by both methods, 37 were detected by veSEQ-HIV only (frequency range: 5.0%–30.6%) and two were detected by ViroSeq only. HIV viral loads estimated by veSEQ-HIV strongly correlated with results from the Abbott RealTime Viral Load assay (R2 = 0.85; n = 142).

Conclusions
The NGS-based veSEQ-HIV method provided results for most samples with higher viral loads, was accurate for detecting major DRMs, and detected mutations at lower levels compared with a method based on population sequencing. The veSEQ-HIV method also provided HIV viral load data.
Early Acute Kidney Injury Following Major Burns
Authors: Ho George , Camacho Fernando , Rogers Alan , Cartotto Robert 
Published: August 2020

AbstractAcute kidney injury (AKI) early after a major burn has not been widely studied. Our purpose was to evaluate the prevalence of and risk factors for early AKI and the effect of early AKI on outcome. Retrospective cohort study of adults with burns ≥20% TBSA admitted between November 24, 2015 and July 1, 2019. “Early AKI” occurring within 7 days of injury was identified using urine output and serum creatinine Kidney Disease International Global Outcome criteria. Multivariate regression models were developed for development of early AKI, development of AKI on day 0 or 1 postburn (“very early AKI”), and for in-hospital death. Among 85 patients, 62.4% developed early AKI, of which 26% had stage 3 AKI. Renal replacement therapy was required in 64% of stage 3 patients by day 7. Patients with early AKI were significantly older [50 (40.5–61) vs 37.5 (27.2–46.8) years, P &lt; .001], and a significantly greater proportion was intubated in the first 24 hours postburn (90.6 vs 59.4%, P = .001). Resuscitation with high-dose vitamin C (HDVC) was independently associated with more frequent early AKI. Older age was significantly associated and HDVC was closely associated with increased very early AKI. In-hospital mortality was 37.7% for patients with early AKI. Older age, larger burn size, and development of early stage 3 AKI were independently associated with increased in-hospital death. Early AKI is common and carries a poor prognosis for survival. Resuscitation involving HDVC appears to be related to a higher likelihood of early and possibly very early AKI.
Invasive and Quarantine Risks ofCacopsylla chinensis(Hemiptera: Psyllidae) in East Asia: Hybridization or Gene Flow Between Differentiated Lineages
Authors: Tsai Cheng-Lung , Lee Hsien-Chung , Cho Geonho , Liao Yi-Chang , Yang Man-Miao , Yeh Wen-Bin 
Published: August 2020

AbstractPear psyllids are major pests and the causal agents of pear decline disease in orchards. In the past two decades, their outbreaks have raised issues pertaining to invasions and taxonomic identification of the dimorphic Cacopsylla chinensis (Yang and Li) in East Asia. The present study elucidated, as an aid to quarantine management, the invasive origins, differentiation history, and putative gene flow and hybridization between C. chinensis and its sibling species Cacopsylla jukyungi (Kwon). Analyses revealed that the ancestors of C. jukyungi might have diverged from C. chinensis approximately 3.5 million yr ago (Mya) and that differentiation between C. chinensis lineages I and II probably occurred 1.5 Mya. The known overlapping distribution of C. chinensis and C. jukyungi in northeastern China and the two C. chinensis lineages in the Bohai Rim region and Taiwan could be attributed to recent population expansion after the Last Glacial Maximum and/or anthropogenic activities. Analyses of the nuclear gene demonstrated that frequent gene flow between the two C. chinensis lineages and the paraphyletic relationship between C. chinensis and C. jukyungi might be caused by incomplete lineage sorting or hybridization events. On the basis of the current distribution, it is evident that C. jukyungi is not present in middle-southern China, whereas C. chinensis is not distributed in Japan and Korea. Preventing new invasions of Cacopsylla psyllids among geographic regions through the transportation of pear scions is thus pivotal in East Asia, particularly for the possible genetic exchanges among differentiated lineages after secondary invasion events.
How has arthroscopic management of the iliopsoas evolved, and why? A survey of high-volume arthroscopic hip surgeons
Authors: Chen Austin W , Steffes Matthew J , Laseter Joseph R , Maldonado David R , Ortiz-Declet Victor , Perets Itay , Domb Benjamin G 
Published: August 2020

AbstractThe rapid growth of hip preservation has left surgeons following trends based on limited, or even anecdotal, evidence in certain circumstances. A consensus as well as high-level research on how best to manage the iliopsoas is lacking. Arthroscopic treatment of the iliopsoas may be an example of how treatment patterns and trends can shift with limited evidence-based medicine. A cross-sectional survey of 16 high-volume hip preservation surgeons was conducted to gather perspectives and opinions on how and why the arthroscopic management of the iliopsoas has evolved. All participants completed the survey in person and anonymously. Of the surveyed surgeons, the mean career hip preservation volume was 1031.25 cases (250 to &gt;3000) with an average annual volume of 162.08 cases (75–400). Of the surveyed surgeons’ caseload, 16.1% involved an iliopsoas tenotomy or fractional lengthening mostly commonly (75%) for recalcitrant internal snapping. Labral repair/reconstruction is performed concomitantly 87.5% of the time. Seventy-five percent of surgeons indicated a decrease in frequency of iliopsoas tenotomy over the course of their practice most commonly (56.3%) because of hip flexion weakness; however, 0% of the surgeons could cite literature evidence to support their practices. Perceived poor outcomes in individual practices was the most common (56.3%) source of this complication. Surgeons were less inclined to perform tenotomy on patients with borderline dysplasia (75%) or ligamentous laxity (56.3%).
Anthropogenic disturbance and chimpanzee (Pan troglodytes) habitat use in the Masito-Ugalla Ecosystem, Tanzania
Authors: Maijo Simula P , Piel Alex K , Treydte Anna C 
Published: August 2020

AbstractThe habitat quality of chimpanzee (Pan troglodytes), including the availability of plant food and nesting species, is important to ensure the long-term survival of this endangered species. Botanical composition of vegetation is spatially variable and depends on soil characteristics, weather, topography, and numerous other biotic and abiotic factors. There are few data regarding the availability of chimpanzee plant food and nesting species in the Masito-Ugalla Ecosystem (MUE), a vast area that lies outside national park boundaries in Tanzania, and how the availability of these resources varies with human disturbance. We hypothesized that chimpanzee plant food species richness, diversity, and abundance decline with increasing human disturbance. Further, we predicted that chimpanzee abundance and habitat use is influenced negatively by human disturbance. Published literature from Issa Valley, Gombe, and Mahale Mountains National Parks, in Tanzania, was used to document plant species consumed by chimpanzees, and quantify their richness, diversity, and abundance, along 32 transects totaling 63.8 km in length across four sites of varying human disturbance in MUE. We documented 102 chimpanzee plant food species and found a significant differences in their species richness (H = 55.09, P &lt; 0.001) and diversity (H = 36.81, P &lt; 0.001) across disturbance levels, with the moderately disturbed site exhibiting the highest species richness and diversity. Chimpanzees built nests in 17 different tree species. The abundance of nesting tree species did not vary across survey sites (H = 0.279, P &gt; 0.964). The least disturbed site exhibited the highest encounter rate of chimpanzee nests/km, with rates declining toward the highly disturbed sites. Our results show that severe anthropogenic disturbance in MUE is associated with the loss of chimpanzee plant food species and negatively influences chimpanzee habitat use, a relationship that threatens the future of all chimpanzee populations outside national parks.