bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimated Frequency of Psychodermatologic Conditions in Alberta, Canada
Authors: Turk Tarek , Dytoc Marlene , Youngson Erik , Abba-Aji Adam , Mathura Pamela , Fujiwara Esther 
Published: September 2020

Background Psychodermatologic disorders are difficult to identify and treat. Knowledge about the prevalence of these conditions in dermatological practice in Canada is scarce. This hampers our ability to address potential gaps and establish optimal care pathways. Objectives To provide an estimate of the frequencies of psychodermatologic conditions in dermatological practice in Alberta, Canada. Methods Two administrative provincial databases were used to estimate the prevalence of potential psychodermatological conditions in Alberta from 2014 to 2018. Province-wide dermatology claims data were examined to extract relevant International Classification of Disease codes as available. Claims were linked with pharmacy dispensation data to identify patients who received at least 1 psychoactive medication within 90 days of the dermatology claim. Results Of 243 963 patients identified, 28.6% had received at least 1 psychotropic medication (mean age: 47.9 years; 67.5% female). Rates of concurrent psychotropic medications were highest for pruritus and related conditions (46.7%), followed by urticaria (44.5%) and hyperhidrosis (32.8%). Among patients with psychotropic medications, rates of antidepressants were highest (56.3%), followed by anxiolytics (37.1%). Across billing codes, besides hyperhidrosis (71.2%), diseases of hair (61.4%) and psoriasis (59.1%) had the highest rates of antidepressant dispensations. Patients with atopic dermatitis had the highest rates for anxiolytic prescriptions (54.3%). Conclusion In a 5-year window, more than a quarter of the identified dermatology patients in Alberta received at least 1 psychotropic medication, pointing to high rates of potential psychodermatologic conditions and/or concurrent mental health issues in dermatology. Diagnostic and care pathways should include a multidisciplinary approach to better identify and treat these conditions.
Characteristic Clinical and Dermoscopic Features of Nonvolar Poroma
Authors: Ha Dae-Lyong , Lee Gi-Wook , Shin Kihyuk , Kim Hoon-Soo , Ko Hyun-Chang , Kim Byung-Soo , Kim Moon-Bum 
Published: September 2020

Background A poroma typically presents as a solitary, pink-to-red papule or nodule in acral volar areas. However, in nonvolar areas, this typical clinical feature (TCF) can be difficult to identify. Objective We aimed to compare clinical and dermoscopic characteristics between nonvolar poroma (NVP) and volar (ie, typical) poroma (VP). Methods We assessed the clinical and dermoscopic characteristics of 40 patients with poromas who were divided into the NVP and VP groups. Results Of the 40 patients, 20 (50.0%) were allocated to the NVP group and 20 (50.0%) to the VP group. Pigmented variants were more common in the NVP group than in the VP group (60.0% vs 5.0%). The TCF of poroma was observed less frequently in the NVP than the VP group (45.0% vs 85.0%). Approximately one-third (30.0%) of patients with NVP received an initial clinical diagnosis of skin cancer. Dermoscopic patterns associated with melanoma or basal cell carcinoma were more common in the NVP group than in the VP group (65% vs 30%). Conclusions Skin cancer-associated clinicodermoscopic features were more frequently observed in patients with NVP, who simultaneously lost dermoscopic patterns associated to poromas and acquired those associated with skin cancer, than those with VP.
Translation, cultural adaptation, and validation of the 10-year Fracture Risk Assessment Tool into Filipino
Authors: del Rosario Pauline Melisse S , Ticman Misael Jonathan A , Caro Leo Daniel D 
Published: September 2020

Introduction: Screening tools for osteoporosis are relatively expensive and inaccessible to the general Filipino population. This study aims to develop a Filipino version of a validated measure, the Fracture Risk Assessment Tool (FRAX), in order to facilitate improvement of fracture prevention care in the country. Methods: The FRAX was translated and culturally adapted into a Filipino version using established forward and backward translation methods and was succeedingly tested for equivalence to the original. The final version was administered to 120 outpatients and was tested for reliability using peripheral dual-energy x-ray absorptiometry (DXA) measurements of the distal radius. Results: To be better understood and reliably answered by the Filipino population, several qualifiers were added to items such as previous fracture and rheumatoid arthritis. This was to account for the high incidence of high-energy trauma in the country and the use of the same Filipino term for rheumatoid arthritis (RA) as with other arthritides, respectively. Conclusion: The Filipino version of the FRAX appears to be an acceptable and reliable instrument, serving as a low-cost alternative to bone mineral density (BMD) and DXA scans which are generally inaccessible and unaffordable by majority of the populations.
Cigarette smoke-initiated autoimmunity facilitates sensitisation to elastin-induced COPD-like pathologies in mice
Authors: Zhou Jie-Sen , Li Zhou-Yang , Xu Xu-Chen , Zhao Yun , Wang Yong , Chen Hai-Pin , Zhang Min , Wu Yin-Fang , Lai Tian-Wen , Di Chun-Hong , Dong Ling-Ling , Liu Juan , Xuan Nan-Xia , Zhu Chen , Wu Yan-Ping , Huang Hua-Qiong , Yan Fu-Gui , Hua Wen , Wang Yi , Xiong Wei-Ning , Qiu Hui , Chen Tao , Weng Dong , Li Hui-Ping , Zhou Xiaobo , Wang Lie , Liu Fang , Lin Xin , Ying Song-Min , Li Wen , Imamura Mitsuru , Choi Mary E. , Stampfli Martin R. , Choi Augustine M.K. , Chen Zhi-Hua , Shen Hua-Hao 
Published: September 2020

It is currently not understood whether cigarette smoke exposure facilitates sensitisation to self-antigens and whether ensuing auto-reactive T cells drive chronic obstructive pulmonary disease (COPD)-associated pathologies.To address this question, mice were exposed to cigarette smoke for 2 weeks. Following a 2-week period of rest, mice were challenged intratracheally with elastin for 3 days or 1 month.Rag1−/−,Mmp12−/−, andIl17a−/−mice and neutralising antibodies against active elastin fragments were used for mechanistic investigations. Human GVAPGVGVAPGV/HLA-A*02:01 tetramer was synthesised to assess the presence of elastin-specific T cells in patients with COPD.We observed that 2 weeks of cigarette smoke exposure induced an elastin-specific T cell response that led to neutrophilic airway inflammation and mucus hyperproduction following elastin recall challenge. Repeated elastin challenge for 1 month resulted in airway remodelling, lung function decline and airspace enlargement. Elastin-specific T cell recall responses were dose dependent and memory lasted for over 6 months. Adoptive T cell transfer and studies in T cells deficientRag1−/−mice conclusively implicated T cells in these processes. Mechanistically, cigarette smoke exposure-induced elastin-specific T cell responses were matrix metalloproteinase (MMP)12-dependent, while the ensuing immune inflammatory processes were interleukin 17A-driven. Anti-elastin antibodies and T cells specific for elastin peptides were increased in patients with COPD.These data demonstrate that MMP12-generated elastin fragments serve as a self-antigen and drive the cigarette smoke-induced autoimmune processes in mice that result in a bronchitis-like phenotype and airspace enlargement. The study provides proof of concept of cigarette smoke-induced autoimmune processes and may serve as a novel mouse model of COPD.
A Survey of Mathematical Tools in Topology and Performance Integrated Modeling and Design of Robotic Mechanism
Authors: Huo Xinming , Yang Shuofei , Lian Binbin , Sun Tao , Song Yimin 
Published: September 2020

AbstractTopology and performance are the two main topics dealt in the development of robotic mechanisms. However, it is still a challenge to connect them by integrating the modeling and design process of both parts in a unified frame. As the properties associated with topology and performance, finite motion and instantaneous motion of the robot play key roles in the procedure. On the purpose of providing a fundamental preparation for integrated modeling and design, this paper carries out a review on the existing unified mathematic frameworks for motion description and computation, involving matrix Lie group and Lie algebra, dual quaternion and pure dual quaternion, finite screw and instantaneous screw. Besides the application in robotics, the review of the work from these mathematicians concentrates on the description, composition and intersection operations of the finite and instantaneous motions, especially on the exponential-differential maps which connect the two sides. Furthermore, an in-depth discussion is worked out by investigating the algebraical relationship among these methods and their further progress in integrated robotic development. The presented review offers insightful investigation to the motion description and computation, and therefore would help designers to choose appropriate mathematical tool in the integrated design and modeling and design of mechanisms and robots.
Anatomical, physical, and mechanical properties of four pioneer species in Malaysia
Authors: Hamdan H. , Nordahlia A. S. , Anwar U. M. K. , Iskandar M. Mohd , Omar M. K. Mohamad , K Tumirah 
Published: September 2020

AbstractThe purpose of this study is to evaluate the anatomical, physical, and mechanical properties of four pioneer species, i.e., batai (Paraserianthes moluccana), ludai (Sapium baccatum), mahang (Macaranga gigantea), and sesendok (Endospermum malaccense). Correlation of factors influencing density, shrinkage, and mechanical properties were also discussed. Samples were obtained from the Forest Research Institute Malaysia (FRIM) campus. From the result obtained, these four pioneer species characterised by medium-to-large vessel with absent of tyloses and gum deposit, fine ray, thin walled fibre, runkel ratio less than 1.0, low in density, and mechanical properties. Sesendok has significantly higher value in fibre length, fibre diameter, fibre lumen diameter, fibre wall thickness, vessel diameter, density, MOR, MOE, compression parallel to grain, and shear parallel to grain compared to the other three pioneer species which were 2001 µm, 45 µm, 35 µm, 5.1 µm, 300 µm, 514 kg/m3, 79.5 N/mm2, 9209 N/mm2, 38.7 N/mm2, and 10.1 N/mm2, respectively. Between these four pioneer species, ludai has significantly higher in runkel ratio which was 0.57, whereas mahang shows significantly higher in slenderness ratio and number of vessels/mm2 which were 50.2 and 5 vessel/mm2, respectively. On the other hand, batai has higher tangential, radial and longitudinal shrinkage compared to ludai, mahang, and sesendok which were 3.0%, 2.4%, and 0.8%, respectively. Based on the basic property study, batai, ludai, mahang, and sesendok could be suitable for pulp and paper, plywood, light construction, furniture, interior finishing, and general utility. Fibre length, fibre wall thickness, and vessel diameter correlated significantly with density and mechanical properties. Shrinkage and mechanical properties were significantly influenced by density.
LDNFSGB: prediction of long non-coding rna and disease association using network feature similarity and gradient boosting
Authors: Zhang Yuan , Ye Fei , Xiong Dapeng , Gao Xieping 
Published: September 2020

AbstractBackgroundA large number of experimental studies show that the mutation and regulation of long non-coding RNAs (lncRNAs) are associated with various human diseases. Accurate prediction of lncRNA-disease associations can provide a new perspective for the diagnosis and treatment of diseases. The main function of many lncRNAs is still unclear and using traditional experiments to detect lncRNA-disease associations is time-consuming.ResultsIn this paper, we develop a novel and effective method for the prediction of lncRNA-disease associations using network feature similarity and gradient boosting (LDNFSGB). In LDNFSGB, we first construct a comprehensive feature vector to effectively extract the global and local information of lncRNAs and diseases through considering the disease semantic similarity (DISSS), the lncRNA function similarity (LNCFS), the lncRNA Gaussian interaction profile kernel similarity (LNCGS), the disease Gaussian interaction profile kernel similarity (DISGS), and the lncRNA-disease interaction (LNCDIS). Particularly, two methods are used to calculate the DISSS (LNCFS) for considering the local and global information of disease semantics (lncRNA functions) respectively. An autoencoder is then used to reduce the dimensionality of the feature vector to obtain the optimal feature parameter from the original feature set. Furthermore, we employ the gradient boosting algorithm to obtain the lncRNA-disease association prediction.ConclusionsIn this study, hold-out, leave-one-out cross-validation, and ten-fold cross-validation methods are implemented on three publicly available datasets to evaluate the performance of LDNFSGB. Extensive experiments show that LDNFSGB dramatically outperforms other state-of-the-art methods. The case studies on six diseases, including cancers and non-cancers, further demonstrate the effectiveness of our method in real-world applications.
Retinal layers and visual conductivity changes in a case series of microangiopathic ischemic stroke patients
Authors: Lee John-Ih , Gemerzki Lena , Weise Margit , Boerker Laura , Graf Jonas , Jansen Lea , Guthoff Rainer , Aktas Orhan , Gliem Michael , Jander Sebastian , Hartung Hans-Peter , Albrecht Philipp 
Published: September 2020

Abstract
Background
It is unknown whether microangiopathic ischemic strokes outside the visual pathway go along with subclinical changes of the retinal structure or the visual system. The objectives of this prospective non-interventional case series were to investigate if spectral-domain optical coherence tomography (SD-OCT) or multifocal visual evoked potentials (mfVEPs) can detect structural retinal changes or functional impairment of the visual system in patients with microangiopathic ischemic stroke.

Methods
We used SD-OCT to cross-sectionally analyze the retinal morphology of 15 patients with microangiopathic ischemic stroke according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification not affecting the visual pathway. We employed semi-automated segmentation of macular volume scans to analyze the thickness of the macular retinal layers and peripapillary ring scans to investigate the retinal morphology in comparison to a control group without stroke. Visual function was assessed by the mfVEP technique in 13 microangiopathic ischemic stroke patients.

Results
First peak latency of mfVEPs was significantly delayed in the microangiopathic ischemic stroke group compared to the control patients. Neither the retinal layers nor the mfVEPs’ amplitude differed between the microangiopathic ischemic stroke patients and the control group.

Conclusions
In conclusion, microangiopathic ischemic stroke patients presented a delayed first peak latency in mfVEPs as a sign of subclinical functional impairment of the visual pathway. However, our case series suggests no influence on retinal structure resulting from microangiopathic ischemic stroke outside the visual system. Larger and longitudinal studies are needed to confirm these mfVEP findings.
Long non-coding RNA SNHG3 promotes breast cancer cell proliferation and metastasis by binding to microRNA-154-3p and activating the notch signaling pathway
Authors: Jiang Hongnan , Li Xiaojun , Wang Wei , Dong Honglin 
Published: September 2020

Abstract
Background
Breast cancer (BC) is a malignant tumor that occurs in the epithelial tissue of the breast gland. Long non-coding RNA (lncRNA) small nucleolar RNA host gene 3 (SNHG3) has been found to promote BC cell proliferation and invasion by regulating the microRNA (miR)-101/zinc-finger enhancer binding axis in BC. Herein, the objective of the present study is to evaluate the effect of lncRNA SNHG3 on BC cell proliferation and metastasis with the Notch signaling pathway.

Methods
Differentially expressed lncRNA in BC tissues and normal breast tissues was analyzed. SNHG3 si-RNA-1 and SNHG3 si-RNA-2 were constructed to detect the mechanism of SNHG3 interference in BC cell proliferation, viability, migration and invasion. Then, dual-luciferase reporter gene assay was utilized to verify the binding relation between SNHG3 and miR-154-3p as well as miR-154-3p and Notch2. Moreover, xenograft transplantation was applied to confirm the in vitro experiments.

Results
Highly expressed SNHG3 was observed in BC tissues. The growth of BC cells in vivo and in vitro was evidently repressed after silencing SNHG3. BC cell invasion and migration were inhibited by silencing SNHG3 in vitro. SNHG3 could act as a competing endogenous RNA of miR-154-3p and upregulate the Notch signaling pathway to promote BC cell development. Activation of the Notch signaling pathway can partly reverse the inhibition of cell activity induced by silencing SNHG3.

Conclusion
Our study demonstrated that interfered lncRNA SNHG3 promoted BC cell proliferation and metastasis by activating the Notch signaling pathway. This investigation may offer new insight for BC treatment.
Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML
Authors: Smith James S. , Lappin Katrina M. , Craig Stephanie G. , Liberante Fabio G. , Crean Clare M. , McDade Simon S. , Thompson Alexander , Mills Ken I. , Savage Kienan I. 
Published: September 2020

Abstract
Background
The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), with STAG2 the most frequently mutated complex member.

Methods
Here we use functional genomics (RNA-seq, ChIP-seq and HiChIP) to investigate the impact of chronic STAG2 loss on three-dimensional genome structure and transcriptional programming in a clinically relevant model of chronic STAG2 loss.

Results
The chronic loss of STAG2 led to loss of smaller loop domains and the maintenance/formation of large domains that, in turn, led to altered genome compartmentalisation. These changes in genome structure resulted in altered gene expression, including deregulation of the HOXA locus and the MAPK signalling pathway, resulting in increased sensitivity to MEK inhibition.

Conclusions
The altered genomic architecture driven by the chronic loss of STAG2 results in altered gene expression that may contribute to leukaemogenesis and may be therapeutically targeted.
HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina
Authors: Benencio Paula , Fraile Gonzalez Sindy A. , Ducasa Nicolás , Page Kimberly , Berini Carolina A. , Biglione Mirna M. 
Published: September 2020

Abstract
Background
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2–5% of the infected individuals. Host genetic background might play a role in disease progression. Several previous studies across many countries report HLA haplotype to be one such factor. Here, we sequenced HLA-A, -B and -C of 66 individuals by Sequence-Based Typing (SBT), and compared the frequency of different alleles among ATLL patients, HAM/TSP patients, asymptomatic carriers and non-infected individuals living in Argentina.

Results
The frequency of HLA-A, -B and -C alleles largely matched that of the general population in Argentina. We identified HLA-A*02, HLA-B*35 and HLA-C*07 as associated to protection from ATLL (p = 0.031), susceptibility to HAM/TSP (p < 0.001) and susceptibility to ATLL (p = 0.017), respectively. We also found a strong correlation between high proviral load (PVL) and disease (p = 0.008), but were unable to identify any particular allele associated with high or low PVL.

Conclusions
We have found HLA-A*02, HLA-B*35 and HLA-C*07 to be associated to protection from ATLL (HLA-A*02) and susceptibility to HAM/TSP (HLA-B*35) or to ATLL (HLA-C*07), respectively. Whereas HLA-A*02 protection from ATLL has already been extensively described in other regions of the world, this is the first report that links HLA-B*35 and an increased susceptibility to HAM/TSP. As for HLA-C*07 it has previously been associated to susceptibility to HAM/TSP in other countries but in our population it has been linked to ATLL.
Positive association between physical outcomes and patient-reported outcomes in late-onset Pompe disease: a cross sectional study
Authors: Yuan Meng , Andrinopoulou Eleni-Rosalina , Kruijshaar Michelle E. , Lika Aglina , Harlaar Laurike , van der Ploeg Ans T. , Rizopoulos Dimitris , van der Beek Nadine A. M. E. 
Published: September 2020

Abstract
Background
Pompe disease is a rare, progressive metabolic myopathy. The aim of this study is to investigate the associations of physical outcomes with patient-reported outcome measures (PROMs) in late-onset Pompe disease.

Methods
We included 121 Dutch adult patients with Pompe disease.
Physical outcomes comprised muscle strength (manual muscle testing using Medical Research Council [MRC] grading, hand-held dynamometry [HHD]), walking ability (6-min walk test [6MWT]), and pulmonary function (forced vital capacity [FVC] in upright and supine positions).
PROMs comprised quality of life (Short Form 36 health survey [SF-36]), participation (Rotterdam Handicap Scale [RHS]) and daily-life activities (Rasch-Built Pompe-Specific Activity [R-PAct] Scale).
Analyses were cross-sectional: the time-point before, and closest to, start of Enzyme Replacement Therapy was chosen. Associations between PROMs and physical outcomes were investigated using linear regression models.

Results
RHS and R-PAct scores were better in patients with higher FVC supine and upright, HHD, MRC and 6MWT scores, accounting for the effect of sex, disease duration, use of wheelchair and ventilator support. While the SF-36 Physical Component Summary (PCS) was correlated positively with FVC upright, HHD, MRC and 6MWT scores, there was no significant relationship between the SF-36 Mental Component Summary (MCS) and any of the physical outcomes.

Conclusions
Participation, daily-life activities, and the physical component of quality of life of adult Pompe patients are positively correlated to physical outcomes. This work serves as a first step towards assessing how changes over time in physical outcomes are related to changes in PROMs, and to define the minimal change in physical outcomes required to make an important difference for the patient.