bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Cryotherapy on Sensory, Motor, and Autonomic Neuropathy in Breast Cancer Patients Receiving Paclitaxel: A Randomized, Controlled Trial
Authors: Ng Ding Quan , Tan Chia Jie , Soh Boon Chua , Tan Mabel May Leng , Loh Soon Yue , Tan Yam Eng , Ong Hui Hui , Teng Peggy Pei Chee , Chan Jack Junjie , Chay Wen Yee , Lee Joycelyn , Lai Gillianne , Beh Sok Yuen , Tan Tira Jing Ying , Yap Yoon Sim , Lee Guek Eng , Wong Mabel , Dent Rebecca , Lo Yew Long , Chan Alexandre , Loh Kiley Wei-Jen 
Published: December 2020

Introduction: We conducted a randomized controlled trial evaluating the efficacy and tolerability of cryotherapy in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients with early breast cancer receiving neo/adjuvant weekly paclitaxel.Methods: Patients were recruited from the National Cancer Centre Singapore and randomized (1:1) to receive either cryotherapy or usual care. Cryotherapy was applied as frozen gloves and socks on all extremities from 15 min before paclitaxel until 15 min post-infusion every cycle. Efficacy was measured by patient-reported outcomes (Patient Neurotoxicity Questionnaire [PNQ] and EORTC QLQ-CIPN20) and electrophysiological assessments. The primary endpoint was PNQ severity at 2 weeks after 12 cycles of weekly paclitaxel.Results: A total of 46 patients were recruited, of which 8 dropped out before paclitaxel treatment, leaving 38 evaluable. There was no significant difference in PNQ severity between cryotherapy and usual care at 2 weeks after paclitaxel treatment (sensory: p = 0.721; motor: p = 1.000). A benefit was observed at 3 months post-paclitaxel based on PNQ (sensory: 14.3 vs. 41.2%, p = 0.078; motor: 0 vs. 29.4%, p = 0.012) and CIPN20 (sensory: β = −3.6, 95%CI = −10.5–3.4, p = 0.308; motor: β = −7.3, 95%CI = −14.6–0, p = 0.051). Additionally, cryotherapy subjects have lower CIPN20 autonomic score (β = −5.84, 95%CI = −11.15 to −0.524, p = 0.031) and higher sympathetic skin response hand amplitudes (β = 0.544, 95%CI = 0.108–0.98, p = 0.014), suggesting possible autonomic benefits from cryotherapy. Temporary interruption with cryotherapy occurred in 80.9% of the subjects due to cold intolerance.Conclusions: There is insufficient evidence that cryotherapy prevents sensory neuropathy which may be due to the high rates of cryotherapy interruption in this study. The autonomic benefits of cryotherapy should be further investigated with appropriate outcome measures.Clinical Trial Registration:ClinicalTrials.gov: NCT03429972.
Development of a Novel Autophagy-Related Prognostic Signature and Nomogram for Hepatocellular Carcinoma
Authors: Fang Qiongxuan , Chen Hongsong 
Published: December 2020

BackgroundHepatocellular carcinoma (HCC) is the seventh most common malignancy and the second most common cause of cancer-related deaths. Autophagy plays a crucial role in the development and progression of HCC.MethodsUnivariate and Lasso Cox regression analyses were performed to determine a gene model that was optimal for overall survival (OS) prediction. Patients in the GSE14520 and GSE54236 datasets of the Cancer Genome Atlas (TCGA) were divided into the high-risk and low-risk groups according to established ATG models. Univariate and multivariate Cox regression analyses were used to identify risk factors for OS for the purpose of constructing nomograms. Calibration and receiver operating characteristic (ROC) curves were used to evaluate model performance. Real-time PCR was used to validate the effects of the presence or absence of an autophagy inhibitor on gene expression in HepG2 and Huh7 cell lines.ResultsOS in the high-risk group was significantly shorter than that in the low-risk group. Gene set enrichment analysis (GSEA) indicated that the association between the low-risk group and autophagy- as well as immune-related pathways was significant. ULK2, PPP3CC, and NAFTC1 may play vital roles in preventing HCC progression. Furthermore, tumor environment analysisviaESTIMATION indicated that the low-risk group was associated with high immune and stromal scores. Based on EPIC prediction, CD8+ T and B cell fractions in the TCGA and GSE54236 datasets were significantly higher in the low-risk group than those in the high-risk group. Finally, based on the results of univariate and multivariate analyses three variables were selected for nomogram development. The calibration plots showed good agreement between nomogram prediction and actual observations. Inhibition of autophagy resulted in the overexpression of genes constituting the gene model in HepG2 and Huh7 cells.ConclusionsThe current study determined the role played by autophagy-related genes (ATGs) in the progression of HCC and constructed a novel nomogram that predicts OS in HCC patients, through a combined analysis of TCGA and gene expression omnibus (GEO) databases.
Choosing PD-1 Inhibitors in Oncology Setting, Left or Right?—Lessons From Value Assessment With ASCO-VF and ESMO-MCBS
Authors: Jiang Qian , Feng Mei , Li Youping , Lang Jinyi , Wei Hua , Yu Ting 
Published: December 2020

Background: Influx of innovative therapies and dramatic rise in prices have been prompting value-driven decision-making. Both the American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO) have independently proposed value assessment frameworks.Objectives: To comprehensively examine the value of nivolumab and pembrolizumab by two value assessment frameworks with a cohort of published randomized controlled trials and offer insight into the association between these two frameworks.Methods: Trials were identified with a cutoff date of Nov 30th, 2019. Receiver operating characteristic curves were generated to establish the predictive value of ASCO-VF score to meet ESMO-MCBS grade and discriminate the agreement of these two value assessment tools. Spearman correlation was used to assess the association between monthly cost and ASCO-VF score/ESMO-MCBS grade. Results: 19 randomized controlled trials were eligible. seven (36.8%) trials were of treatment included nivolumab while 12 (63.2%) pembrolizumab. 8 (42.1%) of the trials were of treatments for non-small-cell lung cancer, 5 (26.3%) for melanoma, 2 (10.5%) were for head and neck squamous cell carcinoma, 2 (10.5%) for gastric or gastro-oesophageal junction cancer and 1 (5.3%) for urothelial cancer and renal-cell carcinoma respectively. ASCO scores ranged from 7 to 94.7 with median 40.90. 11 (57.9%) trials met the ESMO criteria for meaningful value achieved. Of 14 trials not meeting the ASCO cutoff score, only 8 did not meet the meaningful ESMO criteria. Agreement between these two frameworks thresholds was only fair (κ = 0.412, P＜0.05). A negative correlation was noted between increment monthly cost and value assessment results.Conclusion: There is only fair correlation between ASCO and ESMO value assessment frameworks. Not all treatment with nivolumab and pembrolizumab meet valuable thresholds.
Identification of an Identical de Novo SCAMP5 Missense Variant in Four Unrelated Patients With Seizures and Severe Neurodevelopmental Delay
Authors: Jiao Xianru , Morleo Manuela , Nigro Vincenzo , Torella Annalaura , D’Arrigo Stefano , Ciaccio Claudia , Pantaleoni Chiara , Gong Pan , Grand Katheryn , Sanchez-Lara Pedro A. , Krier Joel , Fieg Elizabeth , Stergachis Andrew , Wang Xiaodong , Yang Zhixian 
Published: December 2020

Objective: To establish and broaden the phenotypic spectrum of secretory carrier membrane protein (SCAMP5) associated with epilepsy and neurodevelopmental delay.Methods: A Chinese patient was identified at the First Hospital of Peking University, and the three unrelated patients were recruited from two different countries (Italy and United States) through GeneMatcher. SCAMP5 pathogenic variants were identified by whole exome sequencing; clinical data of the patients were retrospectively collected and analyzed.Result: The onset age of seizures was ranged from 6 to 15 months. Patients had different types of seizures, including focal seizures, generalized tonic-clonic seizures and tonic seizure. One patient showed typical autism spectrum disorder (ASD) symptoms. Electroencephalogram (EEG) findings presented as focal or multifocal discharges, sometimes spreading to generalization. Brain magnetic resonance imaging (MRI) abnormalities were present in each patient. Severe intellectual disability and language and motor developmental disorders were found in our patients, with all patients having poor language development and were nonverbal at last follow-up. All but one of the patients could walk independently in childhood, but the ability to walk independently in one patient had deteriorated with age. All patients had abnormal neurological exam findings, mostly signs of extrapyramidal system involvement. Dysmorphic features were found in 2/4 patients, mainly in the face and trunk. All four unrelated patients were found to have the same heterozygous pathogenic SCAMP5 de novo variant (p. Gly180Trp).Conclusion: Epilepsy, severe developmental delay, abnormal neurological exam findings, with or without ASD or variably dysmorphic features and were common in patients with SCAMP5 variant. The onset time and type of seizure varied greatly. The EEG and brain MRI findings were not consistent, but diverse and nonspecific. The motor ability of patients with heterozygous SCAMP5 variant might have a regressive course; language development was more severely affected.
Micro-Rheological Changes of Red Blood Cells in the Presence of an Arterio-Venous Fistula or a Loop-Shaped Venous Graft in the Rat
Authors: Szabo Balazs , Tanczos Bence , Varga Adam , Barath Barbara , Ghanem Souleiman , Rezsabek Zsofia , Al-Smadi Mohammad Walid , Nemeth Norbert 
Published: December 2020

Introduction: In case of kidney failure, hemodialysis is the primary kidney replacement technique. Several vascular access methods used for the therapy, one of which is the arterio-venous fistula (AVF). In the AVF, the blood flow is altered, which can elevate the mechanical stress on the red blood cells (RBCs). This can affect the RBC hemorheological properties, and it can further cause systemic changes. To lower the turbulence and shear stress, we performed a loop-shaped arterio-arterial venous interposition graft (loop-shaped graft) to compare its effect to the conventional AVF.Materials and Methods: Thirty male Wistar were used (permission registration Nr.: 25/2016/UDCAW). The animals were randomly divided into sham-operated, AVF, and loop groups (n = 10/each). The superficial inferior epigastric vein (SIEV) was used to create the AVF and the loop-shaped graft. Blood samples were taken before/after the surgery and at the 1st, 3rd, and 5th postoperative weeks. We measured hemorhelogical, hematological, and blood gas parameters. The microcirculation of the hind limbs was also monitored using Laser Doppler fluxmetry.Results: Hematocrit, RBC count, and hemoglobin decreased by the 1st postoperative week. The erythrocyte aggregation values significantly increased in the fistula group by the 5th week (6.43 ± 2.31 vs. 13.60; p &lt; 0.0001; vs. before operation). At the postoperative 1st week in the loop group, the values showed a significant decrease in RBC deformability. During the maturation period, dominantly at the 5th week, all values were normalized. The operated hind limb’s skin microcirculation significantly increased in the sham and loop group by the 1st week (39 ± 10.57 vs. 73.93 ± 1.97 BFU, p &lt; 0.01). This increase wasn’t observed in the fistula group probably due to a steal-effect.Conclusion: Unlike in the loop group, in the presence of the fistula, several rheological parameters have changed. The loop-shaped graft had only minimal impact on micro-rheological parameters.
Large-Scale Assessment of Health-Related Physical Fitness in French Older Adults: Feasibility and Validity
Authors: Mack-Inocentio Damien , Menai Mehdi , Doré Eric , Doreau Bastien , Gaillard Camille , Finaud Julien , Pereira Bruno , Duché Pascale 
Published: December 2020

Objectives: This study aims to assess the validity, internal consistency, implementation, and feasibility of a sequence of tests, the Vitality Test Battery, designed to measure physical fitness, at a large scale in French older adults.Methods: A total of 528 volunteers (age ≥60 years) took the battery of 10 tests: 6-min walk, trunk strength, hand grip strength, medicine ball throwing, 30-s chair stand, flexibility, balance, plate tapping, ruler drop, and dual task.Results: Internal consistency was high, with the Cronbach alpha coefficients at around 0.77, explaining 64% of the variance. The test–retest correlations (0.3–0.6) between the items were acceptable and displayed an internal consistency property. Although five components explained 65% of the variance, all the items were kept because their eigenvalues were near to 0.9. External consistency was validated by a significant decrease in fitness scores (p &lt; 0.001) with age and body mass index.Discussion: The Vitality Test Battery is a safe, valid tool for assessing physical fitness in persons aged over 60 years.
Is Vestibular Meniere's Disease Associated With Endolymphatic Hydrops?
Authors: Morita Yuka , Takahashi Kuniyuki , Ohshima Shinsuke , Yagi Chihiro , Kitazawa Meiko , Yamagishi Tatsuya , Izumi Shuji , Horii Arata 
Published: December 2020

Background: Vestibular Meniere's disease (American Academy of Ophthalmology and Otolaryngology, 1972) also known as possible Meniere's disease (American Academy of Otolaryngology Head and Neck Surgery, 1995) or vestibular type of atypical Meniere's disease (V-AMD) (Japan Society for Equilibrium Research, 2017) is characterized by an episodic vertigo without hearing loss. Though named as Meniere's disease (MD), this entity may not be caused solely by endolymphatic hydrops (EH).Objective: To estimate the role of EH in vestibular Meniere's disease in comparison with definite Meniere's disease.Methods: Thirty patients with unilateral definite MD and 16 patients with vestibular Meniere's disease were included. Those who met the criteria for definite or probable vestibular migraine were excluded. All patients underwent vestibular assessments including inner ear MRI 4 h after intravenous gadolinium injection, bithermal caloric testing, directional preponderance of vestibulo-ocular reflex in rotatory chair test, cervical- and ocular-vestibular evoked myogenic potential, stepping test, dizziness handicap inventory (DHI), and hospital anxiety and depression scale (HADS). All above tests and frequency/duration of vertigo spells were compared between vestibular Meniere's disease and MD.Results: Even in unilateral MD, cochlear and vestibular endolymphatic hydrops (c-, v-EH) were demonstrated not only in the affected side but also in the healthy side in more than half of patients. Positive rate of v-EH in vestibular Meniere's disease (68.8%) was as high as that of MD (80%). In vestibular Meniere's disease, the number of bilateral EH was higher in the vestibule (56.3%) than that in the cochlea (25.0%). There were no differences in vestibular tests and DHI between vestibular Meniere's disease and MD; however, the frequency of vertigo spells was lower in vestibular Meniere's disease (p = 0.001). The total HADS score in the MD group was significantly higher than that in the vestibular Meniere's disease group.Conclusions: MD is a systemic disease with bilateral involvement of inner ears. V-EH is a major pathophysiology of vestibular Meniere's disease, which would precede c-EH in the development of vestibular Meniere's disease, a milder subtype of MD. MRI is useful for differentiating MD from other vertigo attacks caused by different pathologies in bringing EH into evidence.
PENERAPAN PERATURAN MENTERI PENDIDIKAN DAN KEBUDAYAAN NOMOR 51 TAHUN 2018 TENTANG SISTEM ZONASI PENERIMAAN PESERTA DIDIK BARU DI SMA N 3 SEMARANG
Authors: Supraptiyaningrum Supraptiyaningrum , Muzayanah Muzayanah 
Published: December 2020

Setiap negara mempunyai maksud dalam melaksanakan kesejahteraan terhadap rakyatnya. Negara Indonesia memiliki tujuan sebagaiamana yang telah dituangkan pada pembukaan UUD 1945 pada alinea ke-empat. Salah satunya yaitu untuk mencerdaskan kehidupan bangsa. Mencerdaskan kehidupan bangsa bertujuan untuk memastikan seluruh masyarakat Indonesia memperoleh kesempatan dalam mengenyam pendidikan tanpa pandang bulu. Berdasarkan Undang-Undang Nomor 20 Tahun 2003 dijelaskan bahwa tujuan pendidikan adalah mengembangkan potensi peserta didik. Kementerian Pendidikan dan Kebudayaan menerbitkan peraturan baru soal PPDB, yaitu sistem zonasi yang bertujuan menciptakan suatu pendidikan yang selaras dengan maksud negara serta memeratakan akses layanan bagi peserta didik, maka. Permendikbud Nomor 51 Tahun 2018 membagi atas 3 jalur, yaitu jalur zonasi, jalur prestasi, dan jalur perpindahan orang tua. Tujuan penelitian ini untuk mengetahui peraturan sistem zonasi pada Permendikbud No 51 Tahun 2019, mengetahui bagaimana penerapan Permendikbud Nomor 51 Tahun 2018 di SMA Negeri 3 Semarang, serta hambatan yang terjadi serta bagaimana solusi yang ditawarkan. Hasil penelitan bahwa SMA Negeri 3 Semarang menerapkan pada Undang-Undang yang berlaku dengan menggunakan jalur PPDB antara lain jalur zonasi, jalur prestasi, jalur prestasi zonasi, dan juga jalur perpindahan orang tua. SMA Negeri 3 Semarang dalam pelaksanaan PPDB menggunakan sistem zonasi, mengakui bahwa banyak siswa berprestasi yang tersisihkan. Dengan demikian, Pemerintah Daerah Jawa Tengah memberikan wewenang kepada pihak SMA Negeri 3 Semarang untuk melaksanakan penerapan jalur tambahan yakni jalur prestasi, dan jalur prestasi zonasi, sehingga melalui jalur prestasi dan prestasi zonasi dapat meminimalisir siswa yang tersisih.
Kata kunci : Sistem Zonasi, Implementasi, Permendikbud.
Transición saludable a la discapacidad de la persona adulta con lesión medular
Authors: Fernandez Moya Monserrat , Ortega Jimenez Marcela 
Published: December 2020

La Lesión Medular (LM) representa un evento catastrófico para la persona que adquiere esta discapacidad, durante el proceso de adaptación la persona está expuesta a diversas complicaciones y secuelas derivadas de esta condición. Los fenómenos complejos requieren teoría para comprender e interpretar las relaciones entre conceptos. Objetivo: presentar una derivación teórica y proponer un modelo sobre la teoría de transición saludable a la discapacidad de la persona adulta con Lesión Medular. Material y métodos: se realizó una derivación teórica mediante la metodología propuesta por J. Fawcett. Resultados: adaptación de la Teoría de rango medio de las transiciones en personas adultas con discapacidad por Lesión Medular. Conclusiones: el modelo puede ser útil para explicar cómo las personas en proceso de adaptación a la discapacidad por Lesión Medular, logran el bienestar y cuáles son los factores que influyen durante el proceso.
El daño resarcible en el Código Civil y Comercial de la Nación Argentina
Authors: Furlotti Silvina Carmen 
Published: December 2020

El objetivo de este trabajo es analizar cuál es la noción de daño resarcible que adopta el Código Civil y Comercial de la República Argentina. Si es la lesión a derechos o intereses no contrarios al ordenamiento jurídico o las consecuencias dañosas de esa lesión. Las implicancias prácticas de este análisis se observan en la cuantificación de los daños causados a la integridad sicofísica o por fallecimiento de la persona humana. Es decir, si se indemniza la lesión en si misma (en abstracto) o las consecuencias patrimoniales y no patrimoniales que ella proyecta sobre la damnificada (en concreto). Se analizará la doctrina y la jurisprudencia argentina para finalmente arribar a la conclusión de que el Código Civil y Comercial contempla un daño evento amplio pero, solo, son resarcibles las consecuencias patrimoniales y no patrimoniales que dicha lesión provoca a la víctima
PENGARUH EDUKASI METODE WISH AND CARE PROGRAM TERHADAP PERILAKU DETEKSI DINI KANKER SERVIKS
Authors: Rosyida Desta Ayu Cahya 
Published: December 2020

Penyakit yang paling membahayakan dan juga berdampak fatal apabila ada keterlambatan dalam penanganannya yaitu Kanker Serviks. WHO menunjukkan bahwa di seluruh dunia terdapat 7.9 juta orang meninggal dikarenakan akibat adanya kanker yang diderita pada diri seseorang. Dari Departemen Kesehatan penyakit Kanker Serviks yang dialami oleh setiap wanita 100 per 100.000 penduduk pertahun. Dengan adanya kejadian ini, deteksi kanker serviks sangat dibutuhkan sekali sebagai upaya deteksi dini adanya kanker serviks. Maka dari itu peneliti tertarik meneliti dengan judul pengaruh edukasi metode wish and care program terhadap perilaku deteksi dini kanker serviks.
Penelitian ini menggunakan desain quasi experiment pre post design with a compariso groups, untuk pengambilan sampel dengan purposive sampling. Analisa bivariat dilakukan menggunakan uji Mc. Nemar dengan tujuan mengetahui adanya perbedaan diantara dua kelompok pre dan post setelah diberikan edukasi. Analisa multivariat penelitian ini menggunakan regresi logistik, variabel dependen pada penelitian ini tergolong kategorik.
Hasil penelitian ini menunjukkan faktor sangat dominan yang mempengaruhi perilaku ibu deteksi dini kanker serviks yaitu intervensi edukasi wish and care program dengan nilai yaitu p = 0,011 dan OR 3.053. Dengan hasil tersebut disimpulkan bahwa perlu adanya perilaku yang bisa dikembangkan dalam pemberian edukasi metode wish and care program sebagai metode untuk meningkatkan perilaku untuk deteksi dini kanker serviks. Dan adanya pengaruh metode tersebut.
Innovative Techniques of Teaching English Grammar at Secondary Schools
Authors: Rochmawati Dyah 
Published: December 2020

Learning English grammar is always a difficult process to most of the English as Foreign Language (EFL) learners at secondary school level. Innovative ideas, interesting teaching materials, practicing and drilling learners for learning the English grammar should be done through fun and joyful ways. The main aim of this library study was to identify and describe examples of practical grammar instruction methods in an EFL which employed innovative methodologies. The process of the library-based research involves identifying and locating relevant information, analyzing what has been found, and then developing and expressing the ideas. The results revealed that songs and poems, music, games, and tasks can be employed as tools in the classroom. Using innovative methodologies in teaching English grammar in the classroom at the secondary schools has paved a positive way to students to learn the language meaningfully.