bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world evidence in patient-reported outcomes (PROs) of metastatic castrate-resistant prostate cancer (mCRPC) patients treated with abiraterone acetate + prednisone (AA+P) across Canada: Final results of COSMiC
Authors: Gotto Geoffrey , Drachenberg Darrel E. , Chin Joseph , Casey Richard , Fradet Vincent , Sabbagh Robert , Shayegan Bobby , Rendon Ricardo A. , Danielson Brita , Camacho Fernandes , Zardan Anousheh , Plante Richard , Hew Huong , Chan Katherine , Feifer Andrew 
Published: June 2020

Introduction: Abiraterone acetate plus prednisone (AA+P) has shown to significantly improve survival. COSMiC, a Canadian Observational Study in Metastatic Cancer of the Prostate, set out to prospectively amass real-world data on metastatic castrate-resistant prostate cancer (mCRPC) patients managed with AA+P in Canada. Here, we report their patient-reported outcomes (PROs).
Methods: After a median followup of 67.1 weeks, 254 patients were enrolled across 39 sites. Functional Assessment of Cancer Therapy-Prostate (FACT-P), Montreal Cognitive Assessment (MoCA), Brief Pain Inventory-Short form (BPI-SF), Brief Fatigue Inventory (BFI), and Current Health Satisfaction in Prostate Cancer (CHS-PCa) were evaluated at baseline, as well as at weeks 12, 24, 48, and 72 after AA+P initiation. Descriptive analysis was used with continuous variables. Changes from baseline were summarized using mean (standard deviation [SD]).
Results: At a median age of 76.6 (8.94), baseline FACT-P total score was 111.3 (19.56) with no significant change in their functional status observed from baseline over time. The median baseline MoCA score was 25.2 (4.52), yet subsequent assessments showed an absence of cognitive decline while under treatment. Similarly, no meaningful changes were detected in BPI, BFI, and CHS-PCa during the 72-week study period, thus suggesting that patients’ PROs were well-maintained throughout AA+P treatment. Prostate-specific antigen (PSA) response with >50% decline was 66.4%. Safety profile was consistent with the known side effect of AA+P.
Conclusions: COSMiC represents the largest Canadian mCRPC cohort treated with AA+P with real-world, prospective evaluation of PROs. This data demonstrated the maintenance in quality of life and cognitive status over the course of the study and underscores the importance of PRO use in this complex patient population.
Canadian experience of neoadjuvant chemotherapy on bladder recurrences in patients managed with trimodal therapy for muscle-invasive bladder cancer
Authors: Ajib Khaled , Tjong Michael C. , Tan Guan Hee , Nason Gregory , Berjaoui Mohammad Baker , Erlich Annette , Maganti Manjula , Sridhar Srikala , Fleshner Neil E. , Zlotta Alexandre R. , Catton Charles , Berlin Alejandro , Chung Peter , Kulkarni Girish S. 
Published: June 2020

Introduction: Bladder preservation with trimodal therapy (TMT) has emerged as a feasible alternative to radical cystectomy in patients with muscle-invasive bladder cancer. Neoadjuvant chemotherapy (NAC) was proven to cause pathological downstaging. For this reason, we evaluated whether receipt of NAC decreases local bladder recurrences in TMT patients.
Methods: We retrospectively analyzed our TMT database for all patients treated between 2003 and 2017. Patients were treated with maximal transurethral resection of bladder tumor (TURBT) followed by chemotherapy/radiotherapy with or without NAC. Baseline demographic and tumor characteristics were recorded. Rates of local and systemic recurrence were analyzed per receipt of NAC. Overall recurrence-free survival (RFS) and bladder (B) RFS were analyzed using the Kaplan-Meier method and Cox proportional hazards modelling.
Results: Median age and followup periods were 72 years and 3.6 years, respectively. Fifty-four patients had NAC and concurrent chemoradiation (NAC-TMT) vs. 70 patients who had concurrent chemoradiation only (TMT). Carcinoma in situ (CIS) was present in 31% of the patients in NAC-TMT group compared to 24% in TMT group (p=0.40). After treatment, 24 (44%) and 31 (44%) patients in NAC-TMT and TMT groups, respectively, had bladder tumor recurrence. Overall RFS at three years was 46% and 50% in NAC-TMT and TMT groups, respectively (p=0.70). BRFS at three years was 55% and 69% in NAC-TMT and TMT groups, respectively (p=0.27). Multivariable analyses found that the presence of concomitant CIS (hazard ratio 2.13; 95% confidence interval CI 1.06–4.27; p=0.0036) was the primary factor associated with local bladder recurrence.
Conclusions: Receipt of NAC does not obviate the risk of bladder recurrence post-TMT. Patients with CIS should be monitored especially closely for local recurrence.
Los movimientos indígenas y la globalización en los reportajes de Manuel Vázquez Montalbán
Authors: Gacinska Weselina 
Published: June 2020

El artículo analiza la presencia de la temática indígena en la obra de Manuel Vázquez Montalbán, ya que esta, debido al carácter político y social de los escritos que la abarcan, está fuertemente vinculada con la globalización y el neoliberalismo. En la poesía, Vázquez Montalbán recurre a la figura indígena en los textos “Las palabras descansan en la bandeja y “En Conemara” recogidos en el poemario Pero el viajero que huye (1990). Allí el indígena, o el “indio”, es percibido a través de una mirada occidental, incidiendo en la pérdida de la identidad. Posteriormente, en la entrevista con Rigoberta Menchú incluida en Y Dios entró en la Habana (1998), el autor profundiza en sus reflexiones acerca de la autodeterminación de los pueblos indígenas de Chiapas y Guatemala, que serán desarrolladas en Marcos: El señor de los espejos (1999). Tanto Menchú como Marcos aportan una visión desmitificadora de la lucha indígena y de la relación de las etnias con los “ladinos”, siempre dentro del marco ideológico anticapitalista y antiglobalizador. Se estudia el acercamiento crítico de Vázquez Montalbán a los planteamientos de los líderes indígenas y se sistematiza desde el punto de vista antropológico las reflexiones sobre la cultura, el mestizaje y el sincretismo.
Palabras clave: indigenismo; Chiapas; antropología; globalización; Subcomandante Marcos; Rigoberta Menchú.
Keywords: indigenismo; Chiapas; anthropology; globalization; Subcomandante Marcos; Rigoberta Menchú.
Título en inglés: Indigenous movements and globalization in the journalistic reports of Manuel Vázquez Montalbán
À CHEVAL SUR LA FRONTIÈRE ENTRE DEUX ÉTATS
Authors: Proulx Isabelle 
Published: June 2020

Faites de beaux rêves de Jacques Poulin raconte les aventures de Limoilou,
d’Amadou et de son frère Théo lors d’une joyeuse escapade au Mont-Tremblant où ils assistent
au Grand Prix du Canada de Formule 1. Entre les courses des « dix mille chevaux lâchés d’un
coup » sur la piste, ce trio de gais lurons passera son temps « à inventer toutes sortes
d’histoires ». La mise en récit du réel et de l’imaginaire sera pour eux l’occasion d’une
véritable « métamorphose ludique de l’ego » (Ricoeur). Incarnant une sorte de Don Quichotte
québécois aux allures de mousquetaire chevaleresque et de cowboy téméraire, Théo s’avèrera
être à la fois un modèle et un guide pour Amadou, « commis aux écritures » en quête de son
identité. Cette étrange petite fable poulinienne est en quelque sorte une invitation amicale
à se laisser prendre au jeu de la littérature, autrement dit, à apprendre à rêver le monde
autrement.
MÉTIS IMAGINAIRES, PENSÉES MÉTISSES ET IMAGINAIRE MÉTISSÉ CHEZ JACQUES POULIN
Authors: Sing Pamela V. 
Published: June 2020

Aujourd’hui, il serait problématique d’imaginer que le « grand roman de l’Amérique » puisse ne pas inclure des personnages et des thèmes autochtones. Cependant, la représentation d’Autochtones par des auteurs allochtones s’avère une entreprise tout aussi problématique. Comment s’y prendre en évitant les images fausses, réductrices, soit d’une manière respectueuse et bien informée ? Dans cet article, Pamela Sing propose des éléments de réponse à cette question en examinant le rôle joué par le personnage de la Métisse dans Volkswagen Blues et dans L’homme de la Saskatchewan de Jacques Poulin.
Étude des déterminants motivationnels du bienêtre scolaire
Authors: Masson Julien , Fenouillet Fabien 
Published: June 2020

L’objectif de la présente recherche est de mettre à jour les liens qu’entretiennent motivation et bienêtre scolaire. Pour ce faire nous nous sommes appuyés sur trois théories de la motivation entre lesquelles s’établissent des liens conceptuels forts : le sentiment d’efficacité personnelle, les buts d’accomplissement et l’intérêt. Nous avons testé un modèle où l’effet du sentiment d’efficacité personnelle est médié par les deux buts d’approche (apprentissage et performance) et par l’intérêt scolaire. Le modèle s’ajuste correctement aux données, et l’analyse des parcours indique que le but d’approche de l’apprentissage sera seul médiateur entre le sentiment d’efficacité personnelle et l’intérêt. Conformément à nos hypothèses, le but d’approche de l’apprentissage a un effet positif sur le bienêtre, alors que l’effet du but d’approche de la performance est négatif. Nous constatons également que parmi les variables prises en considération, c’est l’intérêt scolaire qui est le plus fortement en lien direct avec le bienêtre de l’élève.
L’expérience du soin aux personnes
Authors: de Miribel Julien , Neuville Anne 
Published: June 2020

Cet article met en perspective l’expérience d’étudiantes sages-femmes et d’infirmiers novices en psychiatrie pour examiner certaines dynamiques de construction du rapport au métier. L’enquête, au sens de Dewey, est privilégiée comme entrée analytique. À partir du discours de soignants sur des situations identifiées comme subjectivement significatives, l’analyse fait ressortir des propositions apportées dans le courant l’activité soignante. Celles-ci conduisent à mettre en lumière trois dimensions constitutives du rapport au métier, lesquelles sont ici particulièrement dégagées et discutées : le rapport à un autrui vulnérable, la place de l’incertitude dans l’activité soignante et la construction d’un sens clinique.
Effect of Different Growing Periods on the Nutritional Composition of Cowpea (Vigna unguiculata) Leaves
Authors: Maringa Christine Wanja , Nawata Eiji , Ogutu Fredrick Onyango , Anuro Japheth Abuor 
Published: June 2020

Introduction: The nutritional composition of plant tissues is influenced by climatic conditions during their growth and development. Climate influences the growth rate, chemical composition and yield of crops. This study was conducted to evaluate the effect of growing periods on the nutritional composition of six cowpea varieties; Kenyan local variety (KLV), Indonesian local variety (ILV), Malaysian local variety (MLV), Japanese local variety (JLV) and two Kenyan varieties (K80 and KenKunde).
Methodology: The seeds were grown in an experimental glasshouse under three varying growing periods in 2015 and 2016, respectively. The effect of growing condition on moisture, protein, potassium, calcium, magnesium, manganese, iron and zinc content was assessed.
Results: Moisture content varied from 67.9% to 78.0% and 81.1% to 88.8% in 2015 and 2016, respectively; while protein contents ranged from 7.3% to 14.6% and 18. 4% to 30.4% in 2015 and 2016, respectively. In 2015, there was a significant increase in moisture content, protein, K, Ca, Mg and Mn in KLV as temperature increased. This trend was different for ILV and MLV, which showed significant differences across growing periods with the June growing period showing the highest moisture, protein, K, Mg and Mn contents. In 2016, protein, Ca and Mg contents increased in response to increasing temperature across the growing periods. KLV and Kenkunde exhibited higher concentrations of most components.
Conclusion: There were significant differences among varieties and across growing periods in nutrient content implying both variety and climatic conditions affect nutritional composition.
Biochemical and Histopathological Effect of Detarium microcarpum Stem Bark Extract in Wistar Albino Rats
Authors: Mu’azu Abubakar Bilyamini , Baba Yusif Bello , Matinja Adamu Idris 
Published: June 2020

Aim: In this study, the methanol stem bark extract of Detarium microcarpum was evaluated for sub-chronic, biochemical and histopathological studies.
Methodology: Sub-chronic toxicity studies was investigated in rats administered with 35, 70 and 140 mg/kg doses of the extract orally for 28 days using standard laboratory procedures after the acute toxicity was carried out.
Results: The median lethal dose (LD50) of the extract was calculated to be equal to (≥) 5000 mg/kg body weight in rats orally. Serological studies revealed significant (p<0.05) decrease in Alanine aminotransferase (ALT) at all doses tested, while at 140 mg/kg it caused a significant (p<0.05) increase in Alkaline Phosphatase (ALP). At doses of 70 and 140 mg/kg there was a significant (p<0.05) reduction in creatinine level. Histopathological studies on the liver showed moderate hepatocellular necrosis at doses of 35 and 70 mg/kg, while at 140 mg/kg there was intense hepatocellular necrosis, Kupffer cells and lymphocytes hyperplasia. The Kidney showed intense necrosis of tubules and glomerular necrosis with lymphocytes hyperplasia at all doses tested. The spleen also showed intense lymphocyte hyperplasia at all doses with sinusoidal congestion at the lowest dose of 35 mg/kg. The heart showed slight necrosis of cardiac muscle cells at all doses with blood congestion at 35 and 70mg/kg body weight.
Conclusion: The study indicates that prolong use of the extract in the management of disease conditions may be associated with some adverse effect of some vital organs.
Assessment of Standard Precautions’ Practices among Health Care Workers in a Rural Area of South-South Nigeria
Authors: Ehimen Ferguson Ayemere , Akpan Iboro Samuel , Osagiede Emmanuel Friday , Ofili A. N. , Okukpon Pierre Oziegbe , Airefetalor I. A. 
Published: June 2020

Introduction: Occupational exposure to blood and body fluids (BBFs) is a serious public health concern and it constitute a major risk factor for transmission of infectious diseases such as hepatitis B virus (HBV), hepatitis C virus, and human immune deficiency virus. Therefore, regular adherence to standard precautions remains the best strategy advocated by World Health Organization and Centres of Disease Control for controlling occupational exposure to blood and body fluids.
Objectives: To evaluate the knowledge and practice of HCWs, as it relates to exposure to BBFs and adherence to standard precautions.
Methods: A cross-sectional study was carried out within 8 months among primary health care workers. Information on knowledge of exposure to BBFs, standard precaution practices and post-exposure management were collected using interviewers’ administered questionnaire and observational checklist. The study was conducted among two hundred and thirteen health care workers in Ekpoma, Edo State. Data were entered, cleaned and analyzed using SPSS for window, version 16 (SPSS Inc., Chicago, IL, USA) statistical package software.
Results: Sixty eight (41.7%) of cleaners and 29(17.8%) of nurses/community health extension workers were aware of blood borne infections associated with occupational exposure to BBFs compared to doctors, 3(1.8%) and laboratory workers, 4(2.5%). It was also found out that majority (74.2%) of the participants had poor knowledge of infection control practices.
Conclusion: The knowledge and practice of standard precautions was found to be generally poor. Hence, all health care workers should be trained on the principles of infection control and exposure prevention. Also, relevant authorities need to formulate new strategies to create a favorable working environment that will ensure HCWs adherence to standard precautions.
Assessment of Lipid and Atherogenic Profile of Scavengers at Refuse Dumpsites in Port Harcourt, Rivers State, Nigeria
Authors: Nti Happiness I. , Brown Holy , Bartimaeus Ebirien-Agana S. 
Published: June 2020

Aim: Scavengers are individuals who gather waste and recyclable materials from refuse dumpsites, and thus are exposed to varieties of deleterious substances that have the potential to modulate and affect human health. This study was designed to assess the lipid and atherogenic profile of scavengers utilising refuse dumpsites in Port Harcourt, Nigeria.
Methodology: Fifty (50) exposed (scavengers) aged 31.32±9.49 years and 50 non-exposed (control) aged 32.92 ±10.63 years (age-matched) male subjects were sampled. The blood pressure was measured and body mass index calculated from the height and weight of the subjects. Total cholesterol, high density lipoprotein, low density lipoprotein and triglycerides levels of the subjects were determined from fasting serum samples using standard spectrophotometric methods. Atheogenic ratios were also computed using established formulae. The data was analyzed using Statistical Package for Social Sciences (SPSS) version 21 and expressed as mean and standard deviations. Variations between parameters was considered significant at p<0.05.
Results: The result obtained revealed that the mean ± SD of total cholesterol, triglycerides and low density lipoprotein showed no significant difference (p > 0.05) while the level of high density lipoprotein showed significant difference (p < 0.05) between exposed (scavengers) and non-exposed (control) individuals. Body mass index and blood pressure did not also vary significantly (p>0.05) between the two group of subjects.
Conclusion: Cardiovascular disease risk exist among the study subjects as revealed by atherogenic profiling of the subjects indicating the need for life style changes and socio economic intervention among the subjects.
Relationship between Rainfall Pattern in North Central and Southern Nigeria and Some Tropical Climate Systems
Authors: Ugbeji Esmond Gesever , Okpala Kingsley Chukwudi 
Published: June 2020

Monthly rainfall data from meteorological stations in Nigeria are analyzed from 1951 to 1992, to establish their relationship with some Tropical climate systems. The climate systems include Tropical South Atlantic (TSA) sea surface temperature index, North Atlantic Ocean (NAO) atmospheric index, Tropical North Atlantic (TNA) sea surface temperature index, Central India Precipitation (CIP) and and Outgoing Longwave Radiation Anomaly (OLRA)). The rainfall pattern was given in terms of the August break (quantified in terms of the monsoon break intensity (MBI) and annual rainfall anomaly index (RAI). Partial correlation analysis was carried out to determine the effect of the tropical climate systems on the linear association between them and the stations in Nigeria. Our results show that the rainfall anomalies although sometimes intense do not have predictable patterns. The tele connection between CIP and total rainfall in Nigeria suggests that the rainfall patterns in Nigeria is likely to be modulated by the Tropical Easterly Jet (TEJ) connecting rainfall pattern in Central India to that in Nigeria. The August break is observed to be highly variable and does not show a clear discernable pattern of variability. Its variability may be connected with multiple forcings from ocean and mesoscale circulations.
The Effects of Biofertilizers, Organic and Inorganic Nutrient Sources on Growth Parameters and Yield of Piper betle L. (Betlevine) under Gangetic Alluvial Soil of West Bengal
Authors: Dutta Babli , Bandyopadhyay A. K. , Sultana Samima , Mondal Adwaita , Rudra B. C. , Das Ganesh 
Published: June 2020

An experiment was carried out during two consecutive years of 2012-13 and 2013-14 at the experimental site of AICRP on MAP and Betelvine, Bidhan Chandra Krishi Viswavidyalaya, Kalyani, Nadia, West Bengal. The experiment was laid out in a randomized block design (RBD) replicated thrice with 9 treatments comprising of different combinations of organics (Azotobacter, Phosphobacter and mustard oil cake) and inorganic (urea and SSP) sources of nutrients. The maximum vine elongation, basal girth, leaf size, leaf yield and other yield attributing characters were found significantly better under application of Azotobacter @ 10 Kg + 140 kg N (MOC) + Phosphobacter @ 5 Kg + 50 Kg P +100 Kg K ha-1year-1. However, the treatment was statistically at par with Azotobacter @ 5 Kg + 170 Kg N (MOC) + Phosphobacter @ 5 Kg + 50 Kg P + 100 Kg K ha-1year-1 in respect of dry matter production. Hence, the treatment with Azotobacter @ 10 kg + 140 kg N (MOC) + Phosphobacter @ 5 Kg + 50 Kg P +100 Kg K ha-1year-1 application can be used as a best sustainable and eco friendly integrated nutrient management approach for better yield of betelvine under the gangetic alluvial zone of West Bengal.
Assessment of Prevalence and Incidence of Sesame Gall Midge (Asphondylia sesami Felt) in Kafta-Humera District Tigray, Ethiopia
Authors: Kebede Assefa Abadi , Taferee Zerabruk Geremedhin , Golla Weres Negash 
Published: June 2020

Gall midge (Asphondilia sesame Felt) is one of the most serious insect pests of sesame threatening sesame production in Tigray, Ethiopia. The aim of the present study was to assess distribution and incidence of sesame gall midge and its association with different agronomic practices. Field survey was conducted in Kafta-Humera, districts in 2019 cropping season. A total of 60 farmers’ fields were assessed for the prevalence and incidence of the insect. Results indicated that 94% of farmers’ fields were infected by sesame gall midge from the total assessed fields. Sesame gall midge incidence ranged from 33.33-100% in the assessed Kebelles. The mean incidence gall midge was 81.74%. The highest mean incidences were recorded from Bereket, Adebay, Lugdi, Rawuyan. However, the lowest was recorded from Freselam. Mean incidence of sesame gall midge was significantly (p < 0.05) variation with the sowing date, altitude and crop rotation. The lowest mean incidences of sesame gall midge, flower abortion and galled capsule were recorded from the early sowing date, lower altitude and previous grown with sorghum. Overall results of the present study indicated that sesame gall midge is one of the major challenges to sesame production in study areas. Therefore, efforts should be put in place to manage the insect via integration of appropriate management.
Prevalence of and Severity of Depression among Parkinson Disease Patients
Authors: Ohoreorovwori Ugbomah Lucy , Chukwuemeka Stanley Princewill , Frances Adiukwu , Nosakhare Osemwegie NosakhareOsemwegie 
Published: June 2020

Background: The objectives of the study were to determine prevalence and severity of depression among patients with Parkinson’s diseaseand compare with a control group that has comparable disability with PD and ascertain the correlation of depressive symptoms severity with the severity of motor symptoms in Parkinson’s disease (PD).
Methods: This was a comparative cross-sectional descriptive study conducted at the Neurology clinic of University of Port Harcourt Teaching Hospital (UPTH).The presence and severity of depression in patients with PD measured using Becks Depression Inventory (BDI) and severity of PD using Unified Parkinson’s DiseaseRating Scale (UPDRS)-motor.
Results: A total of 40 PD patients and 40 patients with non-complicated hypertension werestudied. This study showed that the prevalence of depression among subjects with Parkinson’s disease was significantly higher 72.5% as compared with control group, further comparing the mean BDI for PD and Hypertension using independent t-test shows statistical significance (t=-3.306, p-value< 0.001). However, there is no significant difference between the severity of depression among PD patients and control. The study also reported difference in the pattern of depressive symptoms as the PD progresses.
Conclusions: The prevalence of depression in this study was significantly higher (72.5%) among patients with PD, with no significant difference in severity of depression. however, the pattern of depressive symptoms shows significant difference as PD progresses.We recommend the integration of mental health services into the care of Parkinson’s disease to ensure regular assessment of their mental health status and prompt treatment.