bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRPV4 and TRPM8 as putative targets for chronic low back pain alleviation
Authors: Fozzato Stefania , Baranzini Nicolò , Bossi Elena , Cinquetti Raffaella , Grimaldi Annalisa , Campomenosi Paola , Surace Michele Francesco 
Published: September 2020

AbstractThe purpose of this study is to investigate the presence of nervous fibers and expression of TRP channels in samples harvested during decompressive/fusion spine surgeries from patients affected by chronic low back pain (CLBP). The aim was to understand if members of this family of receptors played a role in detection and processing of painful stimuli, to eventually define them as potential targets for CLBP alleviation. Expression of transient receptor potential (TRP) channels (A1, V1, V2, V4, and M8) was evaluated in samples from different periarticular sites of 6 patients affected by CLBP, at both protein and transcript levels. The capsular connective pathological tissue appeared infiltrated by sensitive unmyelinated nervous fibers. An increase in TRP channel mRNAs and proteins was observed in the pathological capsule compared with tissues collected from the non-symptomatic area in five of the six analyzed patients, independently by the location and number of affected sites. In particular, TRPV4 and TRPM8 were consistently upregulated in pathological tissues. Interestingly, the only patient showing a different pattern of expression also had a different clinical history. TRPV4 and TRPM8 channels may play a role in CLBP and warrant further investigations as possible therapeutic targets.
Stromal categorization in early oral tongue cancer
Authors: Almangush Alhadi , Bello Ibrahim O. , Heikkinen Ilkka , Hagström Jaana , Haglund Caj , Kowalski Luiz Paulo , Nieminen Pentti , Coletta Ricardo D. , Mäkitie Antti A. , Salo Tuula , Leivo Ilmo 
Published: September 2020

AbstractStromal categorization has been used to classify many epithelial cancer types. We assessed the desmoplastic reaction and compared its significance with other stromal characteristics in early (cT1-2N0) oral tongue squamous cell carcinoma (OTSCC). In this multi-institutional study, we included 308 cases treated for early OTSCC at five Finnish university hospitals or at the A.C. Camargo Cancer Center in São Paulo, Brazil. The desmoplastic reaction was classified as immature, intermediate, or mature based on the amount of hyalinized keloid-like collagen and myxoid stroma. We compared the prognostic value of the desmoplastic reaction with a stromal grading system based on tumor-stroma ratio and stromal tumor-infiltrating lymphocytes. We found that a high amount of stroma with a weak infiltration of lymphocytes was associated statistically significantly with a worse disease-free survival with a hazard ratio (HR) of 2.68 (95% CI 1.26–5.69), worse overall survival (HR 2.95, 95% CI 1.69–5.15), and poor disease-specific survival (HR 2.66, 95% CI 1.11–6.33). Tumors having a high amount of stroma with a weak infiltration of lymphocytes were also significantly associated with a high rate of local recurrence (HR 4.13, 95% CI 1.67–10.24), but no significant association was found with lymph node metastasis (HR 1.27, 95% CI 0.37–4.35). Categorization of the stroma based on desmoplastic reaction (immature, intermediate, mature) showed a low prognostic value for early OTSCC in all survival analyses (P > 0.05). In conclusion, categorization of the stroma based on the amount of stroma and its infiltrating lymphocytes shows clinical relevance in early OTSCC superior to categorization based on the maturity of stroma.
Navigating cancer treatment and care when living with comorbid dementia: an ethnographic study
Authors: Surr Claire , Griffiths Alys W. , Kelley Rachael , Ashley Laura , Cowdell Fiona , Henry Ann , Inman Hayley , Collinson Michelle , Mason Ellen , Farrin Amanda 
Published: September 2020

Abstract
Objectives
The risks of developing cancer and dementia increase as we age; however, this comorbidity remains relatively under-researched. This study reports on the challenges that people affected by comorbid cancer and dementia face when navigating engagement with cancer treatment within secondary care.

Materials and methods
An ethnographic study recruiting 17 people with cancer and dementia, 22 relatives and 19 oncology staff in two UK National Health Service Trusts. Observations (46 h) and informal conversations were conducted during oncology appointments involving people with dementia. Semi-structured interviews (n = 37) with people living with cancer and dementia, their relatives and staff working in various roles across oncology services were also carried out. Data were analysed using ethnographically informed thematic analysis.

Results
People with cancer and dementia experienced challenges across three areas of navigating cancer treatment and care: navigating through multiple services, appointments and layers of often complex information; repeatedly navigating transport to and from hospital; and navigating non-dementia-friendly hospital outpatient environments alongside the cognitive problems associated with dementia.

Conclusions
Dementia impacts patients’ abilities to navigate the many practical aspects of attending hospital for cancer treatment and care. This study indicates the importance of addressing ways to improve the experience of travelling to and from the hospital, alongside extending the ongoing efforts to develop ‘dementia-friendly’ hospital in-patient areas and practices, to outpatient departments. Such steps will serve to improve hospital-based cancer treatment and care and more broadly outpatient appointment experiences for people with dementia and their families.
Relationship between the thermal condition of the Tibetan Plateau and precipitation over the region from eastern Ukraine to North Caucasus during summer
Authors: Chen Junming , Yue Xiaoyuan , Liu Ge , Nan Sulan 
Published: September 2020

AbstractRemarkable climate anomalies occurred in Europe in recent years, but the reasons are not entirely disclosed. This entails further exploring the physical mechanism of anomalous climate variability over Europe on the basis of previous studies. Using NCEP-NCAR reanalysis and CMAP precipitation datasets, we investigated the relationship between the thermal condition of the Tibetan Plateau (TP) and precipitation over Europe during summer and related mechanisms behind through observational analyses and simulation experiments. The results show that the summer TP surface air temperature (SAT) is significantly correlated with the simultaneous precipitation over the region from eastern Ukraine to the North Caucasus (EUNC; 43°–51° N, 34°–46° E) during the period 1979–2017. The effect of anomalous TP heating plays, to some extent, an active role in linking the summer TP SAT with EUNC precipitation. The variability of the TP SAT is a result of the anomalous TP heating, but it can reflect the variability in temperature of a thick tropospheric air column over the TP well. Corresponding to higher (lower) TP SAT, the higher (lower) temperature anomaly appears over the TP and extends westwards through the transport of anomalous temperature fluxes from the TP to the EUNC regions in the upper troposphere, resulting in the expansion (withdrawal) of the South Asian high (SAH) and associated less (more) precipitation over the EUNC region. Numerical simulations basically reproduce the above-mentioned physical process, which confirms that, through stimulating the variability of upper-tropospheric temperatures over the TP and a larger area to its west and associated upstream large-scale atmospheric circulation, the summer TP’s thermal condition can modulate and expand the impact of the SAH to the EUNC region and therefore affect the concurrent precipitation in situ. This study implies an importance of the thermal anomaly of the TP to the variability of EUNC precipitation during summer.
Obedience and Disobedience in Plato’s Crito and the Apology: Anticipating the Democratic Turn of Civil Disobedience
Authors: Marcou Andreas 
Published: September 2020

AbstractFaced with a choice between escaping without consequences and submitting to a democratic decision, Socrates chooses the latter. So immense is Socrates’ duty to obey law, we are led to believe, that even the threat of death is insufficient to abrogate it.Critoproposes several arguments purporting to ground Socrates’ strong duty to obey, with the appeal to the Athenian system’s democratic credentials carrying most of the normative weight. A careful reading of the dialogue, in conjunction with the ‘Apology’, reveals, however, a more complex picture. IfCritosets the conditions that render a regime legitimate, and therefore warranting of obedience, theApologyreveals a legal system’s shortcomings that justify disobedience. This article substantiates this position by delineating circumstances that can justify resistance. Contemporary forms of political resistance can also rely on similar conditions. Plato’s texts anticipate the current democratic turn of civil disobedience.
Feasibility, Acceptance, and Safety of Metacognitive Training for Problem and Pathological Gamblers (Gambling-MCT): A Pilot Study
Authors: Gehlenborg Josefine , Bücker Lara , Berthold Mira , Miegel Franziska , Moritz Steffen 
Published: September 2020

AbstractApproximately 90% of problem and pathological gamblers remain untreated. This treatment gap may be diminished by the implementation of low-threshold treatment programs. As cognitive distortions play a crucial role in the development and maintenance of gambling problems, interventions targeting gambling-related biases may be particularly effective. The aim of the present study was to examine the feasibility, acceptance, and safety of a novel metacognitive training for individuals with gambling problems (Gambling-MCT). Twenty-five participants were included in an uncontrolled pilot trial with two assessment points (intervention). The intervention comprised eight training modules targeting gambling-specific cognitive distortions. At baseline and post assessment, symptom severity, as measured with the PG-YBOCS, and gambling-related cognitive distortions, as measured with the GABS, were assessed. In addition, interim assessments measuring session-specific changes were conducted. Subjective appraisal was examined after each module and also post treatment. On average, participants took part in 4.16 (SD = 2.84) training sessions. Both intent-to-treat and per protocol analyses showed significant improvements on the PG-YBOCS and the GABS (dz = 0.37–1.37). After Bonferroni correction for multiple testing, linear mixed models for the analysis of session-specific changes showed no deterioration in participants’ mental state after any of the modules. Subjective appraisal of Gambling-MCT was good. The present pilot study provides first evidence for the feasibility, acceptance, and safety of Gambling-MCT. Recruitment of participants remains challenging, emphasizing the importance of overcoming patient-related treatment barriers. Future studies need to investigate the efficacy of Gambling-MCT in randomized controlled trials.
The ultrasound risk stratification systems for thyroid nodule have been evaluated against papillary carcinoma. A meta-analysis
Authors: Trimboli Pierpaolo , Castellana Marco , Piccardo Arnoldo , Romanelli Francesco , Grani Giorgio , Giovanella Luca , Durante Cosimo 
Published: September 2020

AbstractThyroid imaging reporting and data systems (TIRADS) are used to stratify the malignancy risk of thyroid nodule by ultrasound (US) examination. We conducted a meta-analysis to evaluate the pooled cancer prevalence and the relative prevalence of papillary, medullary, follicular thyroid cancer (PTC, MTC, and FTC) and other malignancies among nodules included in studies evaluating their performance. Four databases were searched until February 2020. Original articles with at least 1000 nodules, evaluating the performance of at least one TIRADS among AACE/ACE/AME, ACR-TIRADS, ATA, EU-TIRADS, or K-TIRADS, and reporting data on the histological diagnosis of malignant lesions were included. The number of malignant nodules, PTC, FTC, MTC and other malignancies in each study was extracted. For statistical pooling of data, a random-effects model was used. Nine studies were included, evaluating 19,494 thyroid nodules. The overall prevalence of malignancy was 34% (95%CI 21 to 49). Among 6162 histologically proven malignancies, the prevalence of PTC, FTC, MTC and other malignancies was 95%, 2%, 1%, and 1%, respectively. A high heterogeneity was found for all the outcomes. A limited number of studies generally conducted using a retrospective design was found, with possible selection bias. Acknowledging this limitation, TIRADSs should be regarded as accurate tools to diagnose PTC only. Proposed patterns and/or cut-offs should be revised and other strategies considered to improve their performance in the assessment of FTC, MTC and other malignancies.
Droughts Prediction: a Methodology Based on Climate Seasonal Forecasts
Authors: Arnone E. , Cucchi Marco , Gesso Sara Dal , Petitta Marcello , Calmanti Sandro 
Published: September 2020

AbstractThis study proposes a methodology for the drought assessment based on the seasonal forecasts. These are climate predictions of atmospheric variables, such as precipitation, temperature, wind speed, for upcoming season, up to 7 months. In regions particularly vulnerable to droughts and to changes in climate, such as the Mediterranean areas, predictions of precipitation with months in advance are crucial for understanding the possible shifts, for example, in water resource availability. Over Europe, practical applications of seasonal forecasts are still rare, because of the uncertainties of their skills; however, the predictability varies depending on the season and area of application. In this study, we describe a methodology which integrates, through a statistical approach, seasonal forecast and reanalysis data to assess the climate state, i.e. drought or not, of a region for predefined periods in the next future, at monthly scale. Additionally, the skill of the forecasts and the reliability of the released climate state assessment are estimated in terms of the false rate, i.e. the probability of missing alerts or false alarms. The methodology has been first built for a case study in Zakynthos (Greece) and then validated for a case study in Sicily (Italy). The selected locations represent two areas of the Mediterranean region often suffering from drought and water shortage situations. Results showed promising findings, with satisfying matching between predictions and observations, and false rates ranging from 1 to 50%, depending on the selected forecast period.
A life cycle environmental sustainability analysis of microbial protein production via power-to-food approaches
Authors: Sillman J. , Uusitalo V. , Ruuskanen V. , Ojala L. , Kahiluoto H. , Soukka R. , Ahola J. 
Published: September 2020

Abstract
Purpose
Renewable energy produced from wind turbines and solar photovoltaics (PV) has rapidly increased its share in global energy markets. At the same time, interest in producing hydrocarbons via power-to-X (PtX) approaches using renewables has grown as the technology has matured. However, there exist knowledge gaps related to environmental impacts of some PtX approaches. Power-to-food (PtF) application is one of those approaches. To evaluate the environmental impacts of different PtF approaches, life cycle assessment was performed.

Methods
The theoretical environmental potential of a novel concept of PtX technologies was investigated. Because PtX approaches have usually multiple technological solutions, such as the studied PtF application can have, several technological setups were chosen for the study. PtF application is seen as potentially being able to alleviate concerns about the sustainability of the global food sector, for example, as regards the land and water use impacts of food production. This study investigated four different environmental impact categories for microbial protein (MP) production via different technological setups of PtF from a cradle-to-gate perspective. The investigated impact categories include global warming potential, blue-water use, land use, and eutrophication. The research was carried out using a life cycle impact assessment method.

Results and discussion
The results for PtF processes were compared with the impacts of other MP production technologies and soybean production. The results indicate that significantly lower environmental impact can be achieved with PtF compared with the other protein production processes studied. The best-case PtF technology setups cause considerably lower land occupation, eutrophication, and blue-water consumption impacts compared with soybean production. However, the energy source used and the electricity-to-biomass efficiency of the bioreactor greatly affect the sustainability of the PtF approach. Some energy sources and technological choices result in higher environmental impacts than other MP and soybean production. When designing PtF production facilities, special attention should thus be given to the technology used.

Conclusions
With some qualifications, PtF can be considered an option for improving global food security at minimal environmental impact. If the MP via the introduced application substitutes the most harmful practices of production other protein sources, the saved resources could be used to, for example, mitigation purposes or to improve food security elsewhere. However, there still exist challenges, such as food safety–related issues, to be solved before PtF application can be used for commercial use.
Low-complexity CNN with 1D and 2D filters for super-resolution
Authors: Park Jangsoo , Lee Jongseok , Sim Donggyu 
Published: September 2020

AbstractThis paper proposes a low-complexity convolutional neural network (CNN) for super-resolution (SR). The proposed deep-learning model for SR has two layers to deal with horizontal, vertical, and diagonal visual information. The front-end layer extracts the horizontal and vertical high-frequency signals using a CNN with one-dimensional (1D) filters. In the high-resolution image-restoration layer, the high-frequency signals in the diagonal directions are processed by additional two-dimensional (2D) filters. The proposed model consists of 1D and 2D filters, and as a result, we can reduce the computational complexity of the existing SR algorithms, with negligible visual loss. The computational complexity of the proposed algorithm is 71.37%, 61.82%, and 50.78% lower in CPU, TPU, and GPU than the very-deep SR (VDSR) algorithm, with a peak signal-to-noise ratio loss of 0.49 dB.
Dynamics of Rising Bubbles in a Quiescent Slag Bath with Varying Thermo-Physical Properties
Authors: Obiso D. , Schwitalla D. H. , Korobeinikov I. , Meyer B. , Reuter M. , Richter A. 
Published: September 2020

Abstract
The motion of bubbles in a liquid slag bath with temperature gradients is investigated by means of 3D fluid dynamic computations. The goal of the work is to describe the dynamics of the rising bubbles, taking into account the temperature dependency of the thermo-physical properties of the slag. Attention is paid to the modeling approach used for the slag properties and how this affects the simulation of the bubble motion. In particular, the usage of constant values is compared to the usage of temperature-dependent data, taken from models available in the literature and from in-house experimental measurements. Although the present study focuses on temperature gradients, the consideration of varying thermo-physical properties is greatly relevant for the fluid dynamic modeling of reactive slag baths, since the same effect is given by heterogeneous species and solid fraction distributions. CFD is applied to evaluate the bubble dynamics in terms of the rising path, terminal bubble shape, and velocity, the gas–liquid interface area, and the appearance of break-up phenomena. It is shown that the presence of a thermal gradient strongly acts on the gas–liquid interaction when the temperature-dependent properties are considered. Furthermore, the use of literature models and experimental data produces different results, demonstrating the importance of correctly modeling the slag’s thermo-physical properties.
Model for Inclusion Precipitation Kinetics During Solidification of Steel Applications in MnS and TiN Inclusions
Authors: Shu Qifeng , Visuri Ville-Valtteri , Alatarvas Tuomas , Fabritius Timo 
Published: September 2020

Abstract
A simulation model for inclusion precipitation kinetics during solidification of steel was proposed in this work. With the aim to calculate the inclusion size distribution during solidification of steel, the microsegregation calculation combined with the Kampmann–Wagner numerical (KWN) model for nucleation and growth of inclusion was incorporated into the present simulation model for calculating the evolution of inclusion size distribution during solidification of steel. The inclusion agglomeration due to Brownian collisions was also taken into account. The present simulation model was first applied in simulating precipitation of MnS during steel solidification and validated by the experimental data available in the literature. The effects of cooling rates and sulfur concentrations on the precipitation of MnS were investigated by the model calculations. Then, the present simulation model was applied in simulating the precipitation of TiN inclusions during steel solidification. The calculated mean size was found to be in good agreement with data available in the literature. Finally, the model was employed for studying the effects of interfacial tension between TiN and steel due to sulfur concentration change and cooling rates on the inclusion precipitation kinetics. It was found that interfacial tension between TiN and steel has a crucial influence on the precipitation of TiN. With an increase of the cooling rate, the size distribution of TiN transforms from the lognormal distribution to the bimodal distribution.