bluuebunny/crossref_metadata_2025_split huggingface dataset:
Markedly different patterns of imbibition in seeds of 48 Acacia species
Authors: Burrows Geoffrey E. , Alden Rowan , Robinson Wayne A. 
Published: December 2019

AbstractThe seeds of most Australian acacias have pronounced physical dormancy (PY). While fire and hot water (HW) treatments cause the lens to ‘pop’ almost instantaneously, for many Acacia species the increase in germination percentage can be gradual. If PY is broken instantly by HW treatment, why is germination often an extended process? Control and HW treatments were performed on seeds of 48 species of Acacia. Seeds were placed on a moist substrate and imbibition was assessed by frequently weighing individual seeds. In the two soft-seeded species all control seeds were fully imbibed within 6–24 h, while in hard-seeded species very few control seeds imbibed over several weeks. In 10 species over 50% of the HW-treated seeds imbibed within 30 h, but mostly the percentage of imbibed seeds gradually increased over several weeks. Some seeds in a replicate would imbibe early, while others would remain unimbibed for many days or weeks then, remarkably, become fully imbibed in less than 24 h. While HW treatment broke PY almost instantaneously, it appeared that in many Acacia species some other part of the testa slowed water from reaching the embryo. This process of having staggered imbibition may be a way of ensuring not all seeds in a population germinate after small rain events. Thus it appears the lens acts as a ‘fire gauge’ while some other part of the seed coat acts as a ‘rain gauge’.
Disparities in food consumption between economically segregated urban neighbourhoods
Authors: Lopes Mariana Souza , Caiaffa Waleska Teixeira , Andrade Amanda Cristina de Souza , Malta Deborah Carvalho , Barber Sharrelle , Friche Amélia Augusta de Lima 
Published: December 2019

AbstractObjective:To examine associations between economic residential segregation and prevalence of healthy and unhealthy eating markers.Design:Cross-sectional. A stratified sample was selected in a three-stage process. Prevalence of eating markers and their 95 % CI were estimated according to economic residential segregation: high (most segregated); medium (integrated) and low (less segregated or integrated). Segregation was measured at the census tract and assessed using the Getis–Ord local$G_i^{\rm{\ast}}$statistic based on the proportion of heads of household in a neighbourhood earning a monthly income of 0–3 minimum wages. Binary logistic regression using generalized estimating equations were used to model the associations.Setting:Belo Horizonte, Brazil.Participants:Adults (n1301) residing in the geographical environment (178 census tracts) of ten units of the Brazilian primary-care service known as the Health Academy Program.Results:Of the 1301 participants, 27·7 % lived in highly segregated neighbourhoods, where prevalence of regular consumption of fruit was lower compared with more affluent areas (34·6v. 53·2 %, respectively). Likewise, regular consumption of vegetables (70·1v. 87·6 %), fish (23·6v. 42·3 %) and replacement of lunch or dinner with snacks (0·8v. 4·7 %) were lower in comparison to more affluent areas. In contrast, regular consumption of beans was higher (91·0v. 79·5 %). The associations of high-segregated neighbourhood with consumption of vegetables (OR = 0·62; 95 % CI 0·39, 0·98) and beans (OR = 1·85; 95 % CI 1·07, 3·19) remained significant after adjustments.Conclusions:Economic residential segregation was associated with healthy eating markers even after adjustments for individual-level factors and perceived food environment.
The relationship between mental disorders and actual and desired subjective social status
Authors: de Vries Y. A. , ten Have M. , de Graaf R. , van Dorsselaer S. , de Ruiter N. M. P. , de Jonge P. 
Published: December 2019

Abstract

Aims
Mental disorders are associated with lower subjective social status (SSS), but a more nuanced understanding of this relationship is needed. We examined the influence of disorder age of onset and recency on SSS and studied whether mental disorders are also associated with the discrepancy between actual and desired SSS.

Method
Data are from the baseline and second wave of the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2). Mental disorders were assessed with the Composite International Diagnostic Interview (CIDI 3.0), while both actual and desired SSS were assessed with a ten-rung ladder. Linear regression was used to examine the association between mental disorders and SSS.

Results
Of 5303 participants, 2237 had a lifetime mental disorder at baseline. These participants reported significantly lower actual SSS (6.28) at follow-up than healthy participants (6.66, B = −0.38 [95% CI −0.48 to −0.27], p < 0.001) and a significantly greater actual-desired SSS discrepancy (1.14 v. 1.05 after controlling for actual SSS, B = 0.09 [0.01–0.17], p = 0.024). Lower age of onset of the first mental disorder was marginally significantly associated with lower actual SSS (B = 0.006 [0.000–0.012], p = 0.046). More recent disorders were also associated with lower actual SSS (B = 0.015 [0.005–0.026], p = 0.005), such that participants whose disorder remitted ⩾6 years before baseline were statistically indistinguishable from healthy participants.

Conclusions
Lifetime mental disorders are associated with lower actual SSS and a slightly greater discrepancy between actual and desired SSS. However, people with mental disorders in (long-term) remission have a similar social status as healthy participants.
Tuning in to Kids
Authors: Otterpohl Nantje , Buchenau Katharina , Havighurst Sophie , Stiensmeier-Pelster Joachim , Kehoe Christiane 
Published: December 2019

Zusammenfassung. Es wird eine deutsche Version des Elterntrainings Tuning in to Kids vorgestellt. Das Training zielt über die Förderung elterlicher Strategien zur Emotionssozialisation auf eine Verbesserung kindlicher emotionaler Kompetenzen ab und kombiniert kognitiv-verhaltenstherapeutische Prinzipien mit einem emotionsfokussierten Ansatz. In einer kontrollierten Pilotstudie mit Prä-Posttest-Design (TG: n = 41, KG: n = 30; Alter der Kinder: 3 – 6 Jahre) wurden durch das Training nicht-supportive emotionsbezogene Überzeugungen und Reaktionen auf kindliche Emotionen reduziert sowie supportive Überzeugungen und Reaktionen aufgebaut. Für verschiedene Maße des emotionalen Familienklimas zeigten sich tendenziell positive Effekte. Trotz der Vorläufigkeit der Befunde sprechen die Ergebnisse für eine gute Trainierbarkeit elterlicher Strategien zur Emotionssozialisation und einen stärkeren Einbezug in Prävention und Intervention.
Robust Adaptive Spacecraft Array Derivative Analysis
Authors: Vogt J. , Blagau A. , Pick L. 
Published: December 2019

AbstractMultispacecraft missions such as Cluster, Themis, Swarm, and MMS contribute to the exploration of geospace with their capability to produce gradient and curl estimates from sets of spatially distributed in situ measurements. This paper combines all existing estimators of the reciprocal vector family for spatial derivatives and their errors. The resulting framework proves to be robust and adaptive in the sense that it works reliably for arrays with arbitrary numbers of spacecraft and possibly degenerate geometries. The analysis procedure is illustrated using synthetic data as well as magnetic measurements from the Cluster and Swarm missions. An implementation of the core algorithm in Python is shown to be compact and computationally efficient so that it can be easily integrated in the various free and open source packages for the Space Physics and Heliophysics community.
Oblique Gravity Wave Propagation During Sudden Stratospheric Warmings
Authors: Stephan C. C. , Schmidt H. , Zülicke C. , Matthias V. 
Published: December 2019

AbstractGravity waves (GWs) are important for coupling the mesosphere to the lower atmosphere during sudden stratospheric warmings (SSWs). Here, a minor SSW is internally generated in a simulation with the upper‐atmosphere configuration of the ICOsahedral Nonhydrostatic model. At a horizontal resolution of 20 km the simulation uses no GW drag parameterizations but resolves large fractions of the GW spectrum explicitly, including orographic and nonorographic sources. Consistent with previous studies, the simulated zonal‐mean stratospheric warming is accompanied by zonal‐mean mesospheric cooling. During the course of the SSW the mesospheric GW momentum flux (GWMF) turns from mainly westward to mainly eastward. Waves of large phase speed (40–80 m s
) dominate the eastward GWMF during the peak phase of the warming. The GWMF is strongest along the polar night jet axis. Parameterizations of GWs usually assume straight upward propagation, but this assumption is often not satisfied. In the case studied here, a substantial amount of the GWMF is significantly displaced horizontally between the source region and the dissipation region, implying that the local impact of GWs on the mesosphere does not need to be above their local transmission through the stratosphere. The simulation produces significant vertically misaligned anomalies between the stratosphere and mesosphere. Observations by the Microwave Limb Sounder confirm the poleward tilt with height of the polar night jet and horizontal displacements between mesospheric cooling and stratospheric warming patterns. Thus, lateral GW propagation may be required to explain the middle‐atmosphere temperature evolution in SSW events with significant zonally asymmetric anomalies.
Ocean Kinetic Energy Backscatter Parametrization on Unstructured Grids: Impact on Global Eddy‐Permitting Simulations
Authors: Juricke Stephan , Danilov Sergey , Koldunov Nikolay , Oliver Marcel , Sidorenko Dmitry 
Published: December 2019

AbstractIn this study we demonstrate the potential of a kinetic energy backscatter scheme for use in global ocean simulations. Ocean models commonly employ (bi)harmonic eddy viscosities causing excessive dissipation of kinetic energy in eddy‐permitting simulations. Overdissipation not only affects the smallest resolved scales but also the generation of eddies through baroclinic instabilities, impacting the entire wave number spectrum. The backscatter scheme returns part of this overdissipated energy back into the resolved flow. We employ backscatter in the FESOM2 multiresolution ocean model with a quasi‐uniform 1/4°
mesh. In multidecadal ocean simulations, backscatter increases eddy activity by a factor 2 or more, moving the simulation closer to observational estimates of sea surface height variability. Moreover, mean sea surface height, temperature, and salinity biases are reduced. This amounts to a globally averaged bias reduction of around 10% for each field, which is even larger in the Antarctic Circumpolar Current. However, in some regions such as the coastal Kuroshio, backscatter leads to a slight overenergizing of the flow and, in the Antarctic, to an unrealistic reduction of sea ice. Some of the bias increases can be reduced by a retuning of the model, and we suggest related adjustments to the backscatter scheme. The backscatter simulation is about 2.5 times as expensive as a simulation without backscatter. Most of the increased cost is due to a halving of the time step to accommodate higher simulated velocities.
Radiation Dose During Relativistic Electron Precipitation Events at the International Space Station
Authors: Ueno H. , Nakahira S. , Kataoka R. , Asaoka Y. , Torii S. , Ozawa S. , Matsumoto H. , Bruno A. , de Nolfo G.A. , Collazuol G. , Ricciarini S.B. 
Published: December 2019

AbstractWe provide a quantitative estimate of the radiation dose during relativistic electron precipitation (REP) events at the International Space Station (ISS). To this goal, we take advantage of the data collected by the CALorimetric Electron Telescope, the Monitor of All‐sky X‐ray Image, and the Space Environment Data Acquisition equipment‐Attached Payload. The three ISS detectors offer complementary REP observations, including energy spectra and flux directional information, during a period of approximately 2.5 years, from November 2015 to March 2018. We have identified 762 REP events during this period from which we obtain the distribution of radiation dose, relevant to extravehicular activities outside the ISS.
Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer
Authors: Saraç Hilal , Morova Tunç , Pires Elisabete , McCullagh James , Kaplan Anıl , Cingöz Ahmet , Bagci-Onder Tugba , Önder Tamer , Kawamura Akane , Lack Nathan A. 
Published: December 2019

AbstractAndrogen deprivation therapy (ADT) is the standard care for prostate cancer (PCa) patients who fail surgery or radiotherapy. While initially effective, the cancer almost always recurs as a more aggressive castration resistant prostate cancer (CRPC). Previous studies have demonstrated that chromatin modifying enzymes can play a critical role in the conversion to CRPC. However, only a handful of these potential pharmacological targets have been tested. Therefore, in this study, we conducted a focused shRNA screen of chromatin modifying enzymes previously shown to be involved in cellular differentiation. We found that altering the balance between histone methylation and demethylation impacted growth and proliferation. Of all genes tested, KDM3B, a histone H3K9 demethylase, was found to have the most antiproliferative effect. These results were phenocopied with a KDM3B CRISPR/Cas9 knockout. When tested in several PCa cell lines, the decrease in proliferation was remarkably specific to androgen-independent cells. Genetic rescue experiments showed that only the enzymatically active KDM3B could recover the phenotype. Surprisingly, despite the decreased proliferation of androgen-independent cell no alterations in the cell cycle distribution were observed following KDM3B knockdown. Whole transcriptome analyses revealed changes in the gene expression profile following loss of KDM3B, including downregulation of metabolic enzymes such asARG2andRDH11. Metabolomic analysis of KDM3B knockout showed a decrease in several critical amino acids. Overall, our work reveals, for the first time, the specificity and the dependence of KDM3B in CRPC proliferation.
A review of prostate cancer treatment impact on the CNS and cognitive function
Authors: Ryan Charles , Wefel Jeffrey S. , Morgans Alicia K. 
Published: December 2019

Abstract
Background
Androgen deprivation therapy (ADT) is the backbone of systemic therapy for men with prostate cancer (PC); almost one-half of patients receive treatment during their disease course. However, a range of cognitive and other central nervous system (CNS) changes have been associated with ADT. In this review, we discuss extant data describing these complications and the mechanisms through which medications used to deliver ADT may affect them.

Methods
We performed a MEDLINE search for appropriate papers published between January 2000 and December 2018. Relevant papers were selected and reviewed; additional publications were identified by manually assessing references from included papers, and recent congress abstracts.

Results
Of ~230 search outputs, 33 were selected for inclusion. Some studies suggested a clear association between ADT and CNS effects in men with PC, whereas others did not. Accurate assessment is limited by test instrument variability, inadequate sample sizes, short follow-up duration, and limited prospective longitudinal studies. The approved second-generation androgen receptor (AR) inhibitors enzalutamide and apalutamide were associated with some CNS-related adverse events (AEs) in clinical studies, including fatigue (which can interfere with cognitive function). The androgen synthesis inhibitor abiraterone acetate was associated with a low CNS AE profile when compared with enzalutamide. The AR antagonist darolutamide demonstrated a comparable incidence of cognitive disorder in clinical trials to that of ADT alone.

Conclusions
Adequately caring for men receiving ADT requires an understanding of the symptoms, incidence and magnitude of cognitive effects, and a feasible approach to cognitive assessment and management in clinical settings. Some CNS effects could relate to blood–brain barrier penetration and direct AR inhibitor activity; drug safety profiles may differ by the degree of blood–brain barrier penetration of particular agents. Ongoing clinical trials seek to define the CNS tolerability of newer AR pathway-targeted therapy options more clearly.
Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma
Authors: Gupta Avinash , Towers Christopher , Willenbrock Frances , Brant Roz , Hodgson Darren Richard , Sharpe Alan , Smith Paul , Cutts Anthony , Schuh Anna , Asher Ruth , Myers Kevin , Love Sharon , Collins Linda , Wise Adelyn , Middleton Mark Roy , Macaulay Valentine Moya 
Published: December 2019

Abstract
Background
Aiming to improve treatment options for BRAF wild-type melanoma, we previously conducted the DOC-MEK study of docetaxel with MEK inhibitor (MEKi) selumetinib or placebo, revealing trends to prolongation of progression-free survival (hazard ratio 0.75, P = 0.130), and improved response rates (32% vs 14%, P = 0.059) with docetaxel plus selumetinib. NRAS status did not associate with outcome. Here, the aim was to identify novel biomarkers of response to MEKi.

Methods
A MEK 6 gene signature was quantified using NanoString and correlated with clinical outcomes. Two components of the gene signature were investigated by gene silencing in BRAF/NRAS wild-type melanoma cells.

Results
In melanomas of patients on the selumetinib but not the placebo arm, two gene signature components, dual-specificity protein phosphatase 4 (DUSP4) and ETS translocation variant 4 (ETV4), were expressed more highly in responders than non-responders. In vitro, ETV4 depletion inhibited cell survival but did not influence sensitivity to MEKi selumetinib or trametinib. In contrast, DUSP4-depleted cells showed enhanced cell survival and increased resistance to both selumetinib and trametinib.

Conclusions
ETV4 and DUSP4 associated with clinical response to docetaxel plus selumetinib. DUSP4 depletion induced MEKi resistance, suggesting that DUSP4 is not only a biomarker but also a mediator of MEKi sensitivity.

Clinical Trial Registration
DOC-MEK (EudraCT no: 2009-018153-23).
A multinational observational study identifying primary care patients at risk of overestimation of asthma control
Authors: Kritikos Vicky , Price David , Papi Alberto , Infantino Antonio , Ställberg Bjorn , Ryan Dermot , Lavorini Federico , Chrystyn Henry , Haughney John , Lisspers Karin , Gruffydd-Jones Kevin , Román Rodríguez Miguel , Høegh Henrichsen Svein , van der Molen Thys , Carter Victoria , Bosnic-Anticevich Sinthia 
Published: December 2019

AbstractFactors related to the discrepancy between patient-perceived and actual disease control remain unclear. Identifying patients at risk of overestimation of asthma control remains elusive. This study aimed to (i) investigate the relationship between patient-reported and actual level of asthma control (ii), compare the characteristics between patients who believe their asthma is well controlled that accurately report ‘well-controlled’ asthma with those that do not, and (iii) identify factors associated with inaccurately reported ‘well-controlled’ asthma. A historical, multinational, cross-sectional study using data from the iHARP (initiative Helping Asthma in Real-life Patients) review service for adults with asthma prescribed fixed-dose combination therapy. Data from 4274 patients were analysed. A major discrepancy between patient-reported and Global Initiative for Asthma defined asthma control was detected; 71.1% of patients who reported ‘well-controlled’ asthma were inaccurate in their perception despite receiving regular maintenance therapy. Significant differences were noted in age, gender, body mass index, education level, medication use, side effects, attitudes to preventer inhaler use, inhaler technique review and respiratory specialist review between patients who accurately reported ‘well-controlled’ asthma and those who did not. Independent risk factors associated with inaccurately reported ‘well-controlled’ asthma were: having taken a maximum of 5–12 puffs or more of reliever inhaler on at least one day within the previous 4 weeks; being female; having seen a respiratory specialist more than a year ago (rather than in the previous year); and having required oral corticosteroids for worsening asthma in the previous year. The study highlighted the significant hidden burden associated with under-recognition of poor asthma control, on the part of the patient and the need for targeted interventions designed to address the continuing discrepancy between perceived and actual disease control.
Pan-European groundwater to atmosphere terrestrial systems climatology from a physically consistent simulation
Authors: Furusho-Percot Carina , Goergen Klaus , Hartick Carl , Kulkarni Ketan , Keune Jessica , Kollet Stefan 
Published: December 2019

AbstractApplying the Terrestrial Systems Modeling Platform, TSMP, this study provides the first simulated long-term (1996–2018), high-resolution (~12.5 km) terrestrial system climatology over Europe, which comprises variables from groundwater across the land surface to the top of the atmosphere (G2A). The data set offers an unprecedented opportunity to test hypotheses related to short- and long-range feedback processes in space and time between the different interacting compartments of the terrestrial system. The physical consistency of simulated states and fluxes in the terrestrial system constitutes the uniqueness of the data set: while most regional climate models (RCMs) have a tendency to simplify the soil moisture and groundwater representation, TSMP explicitly simulates a full 3D soil- and groundwater dynamics, closing the terrestrial water cycle from G2A. As anthopogenic impacts are excluded, the dataset may serve as a near-natural reference for global change simulations including human water use and climate change. The data set is available as netCDF files for the pan-European EURO-CORDEX domain.
Wide-Angle Scanning Phased Array Antenna using High Gain Pattern Reconfigurable Antenna Elements
Authors: Ahn ByungKuon , Hwang In-June , Kim Kwang-Seok , Chae Soo-Chang , Yu Jong-Won , Lee Han Lim 
Published: December 2019

AbstractThis paper presents a wide-angle scanning phased array antenna using high gain pattern reconfigurable antenna (PRA) elements. Using PRA elements is an attractive solution for wide-angle scanning phased array antennas because the scanning range can be divided into several subspaces. To achieve the desired scanning performance, some characteristics of the PRA element such as the number of switching modes, tilt angle, and maximum half-power beamwidth (HPBW) are required. We analyzed the required characteristics of the PRA element according to the target scanning range and element spacing, and presented a PRA element design guideline for phased array antennas. In accordance with the guideline, the scanning range was set as ±70° and a high gain PRA element with three reconfigurable patterns was used to compose an 8x1 array antenna with 0.9 λ0 spacing. After analyzing whether the active element patterns meet the guideline, the array antenna was fabricated and measured to demonstrate the scanning performance. The fabricated array can scan its beam from -70° to 70° by dividing the scanning range into three subspaces. It shows that even if the array antenna has large element spacing, the desired scanning performance can be obtained using the elements designed under the guideline.