bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between two different techniques for peri‐implant soft tissue augmentation: Porcine dermal matrix graft versus tenting screw
Authors: Verardi Simone , Orsini Marco , Lombardi Teresa , Ausenda Federico , Testori Tiziano , Pulici Alessandro , Oreglia Francesco , Valente Nicola Alberto , Stacchi Claudio 
Published: December 2019

AbstractBackgroundThe thickness of the soft tissues around dental implants is crucial for both the preservation of the marginal bone and esthetic profile. Many authors have showed the thickened soft tissues favor a better peri‐implant bone stability; however, different thickening techniques can be used for this aim.MethodsForty‐seven patients were enrolled in this study, each one had one implant included in this analysis. According to the thickening procedure, patients were assigned into group A (porcine dermal matrix, n = 24) or B (healing abutment used as tenting screw to sustain the soft tissues, n = 23), soft tissue thickness was measured after flap elevation in a standardized way. Six months after implant placement, implants were uncovered and soft tissue thickness measured again.ResultsAt second stage, 6 months after implant placement, the mean vertical thickness was 3.01 ± 0.58 mm in group A and 2.25 ± 0.53 mm in group B. The difference between the two groups at 6 months was significant (P < 0.001). The mean vertical gain in group A was 1.33 ± 0.71 mm, whereas it was 0.43 ± 0.55 mm in group B. This difference was also statistically significant (P < 0.001).ConclusionThe use of a healing abutment for “tenting effect” has limited efficacy to obtain a significant increase in soft tissue thickness. The use of a porcine dermal matrix at time of implant placement is effective to thicken peri‐implant tissues.
Clinical presentation and surgical outcomes in primary aldosteronism differ by race
Authors: Gershuni Victoria M. , Ermer Jae P. , Kelz Rachel R. , Roses Robert E. , Cohen Debbie L. , Trerotola Scott O. , Fraker Douglas L. , Wachtel Heather 
Published: December 2019

AbstractBackgroundPrimary aldosteronism (PA) is the most common cause of secondary hypertension; early diagnosis and intervention correlate with outcomes. We hypothesized that race may influence clinical presentation and outcomes.MethodsWe conducted a retrospective analysis of patients with PA (1997‐2017) who underwent adrenal vein sampling (AVS). Patients were classified by self‐reported race as black or non‐black. Improvement was defined as postoperative decrease in mean arterial pressure (MAP), antihypertensive medications (AHM), or both.ResultsAmong patients undergoing AVS (n = 443), 287 underwent adrenalectomy. Black patients (28.2%) had higher body mass index (33.9 vs 31.8 kg/m2;P = .01), longer median duration of hypertension (12 vs 10 years;P = .003), higher modified Elixhauser comorbidity index (2 vs 1;P = .004), and lower median income ($47 134 vs $78 280;P < .001). Black patients had similar aldosterone:renin ratios (150 vs 135.6 [ng/dL]/[ng·mL·−1hr−1];P = .23) compared to non‐blacks. At long‐term follow‐up, black patients had a similar requirement for AHM (1 vs 0;P = .13) but higher MAP (100.6 vs 95.3 mm Hg;P = .004).ConclusionBlack patients present with longer duration of hypertension and more comorbidities. They are equally likely to lateralize on AVS, suggesting similar disease phenotype. However, black patients demonstrate less improvement with adrenalectomy; this may reflect a delay in diagnosis or concomitant essential hypertension.
Combination of ultrasound‐assisted ethyl chloroformate derivatization and switchable solvent liquid‐phase microextraction for the sensitive determination of l‐methionine in human plasma by GC–MS
Authors: Erarpat Sezin , Bodur Süleyman , Öztürk Er Elif , Bakırdere Sezgin 
Published: December 2019

AbstractA green and fast analytical method for the determination of l‐methionine in human plasma is presented in this study. Preconcentration of the analyte was carried out by switchable solvent liquid phase microextraction after ethyl chloroformate derivatization reaction. Instrumental detection of the analyte was performed by means of gas chromatography–mass spectrometry. N,N‐Dimethyl benzylamine was used in the synthesis of switchable solvent. Protonated N,N‐dimethyl benzylamine volume, volume/concentration of sodium hydroxide, and vortex period were meticulously fixed to their optimum values. Besides, ethyl chloroformate, pyridine, and ethanol volumes were optimized in order to get high derivatization yield. After the optimization studies, limit of detection and quantitation values were attained as 3.30 and 11.0 ng/g, respectively, by the developed switchable solvent liquid phase microextraction gas chromatography–mass spectrometry method that corresponding to 76.7‐folds enhancement in detection power of the gas chromatography–mass spectrometry system. Applicability and accuracy of the switchable solvent liquid phase microextraction–gas chromatography–mass spectrometry method were also checked by spiking experiments. Percent recovery results were ranged from 97.8 to 100.5% showing that human plasma samples could be analyzed for its l‐methionine level by the proposed method.
The power of the pen: Handwritten fonts promote haptic engagement
Authors: Izadi Anoosha , Patrick Vanessa M. 
Published: December 2019

AbstractConsumers are increasingly bombarded with merchandise and offers, making clear the need for visually distinctive and sensorially engaging product packaging design. The current research demonstrates that the use of handwritten fonts on product packaging elicits an approach tendency and enhances haptic engagement, which influences product evaluation and choice likelihood. A pilot study quantifies the use of handwritten fonts in four grocery product categories to establish that the study of handwritten fonts as a packaging design element is a worthy one with managerial significance. Four experiments are then presented. Studies 1 and 2 use real products to show that a product label with a handwritten (vs. typewritten) font elicits haptic engagement and, enhanced product evaluations (Study 2). Study 3 identifies a boundary condition such that the focal effect is observed only for benign (safe and enjoyable) product categories, but not for risky (unsafe and dangerous) ones. Study 4 relies on a simulated store setup with actual products to illustrate the differential preference for products with a handwritten (vs. typewritten) font when choosing between brands in a benign (vs. risky) product category.
Variation at ACOT12 and CT62 locus represents susceptibility to psoriasis in Han population
Authors: Xing Jianxiao , Zhao Xincheng , Li Xiaofang , Wang Ying , Li Junqin , Hou Ruixia , Niu Xuping , Yin Guohua , Li Xinhua , Zhang Kaiming 
Published: December 2019

AbstractBackgroundPsoriasis is a chronic inflammatory disorder of the skin, and genetic factors are reported to be involved in the disease pathogenesis. Many studies have named psoriasis candidate genes.ObjectiveIn this study, we determined the mutation frequency of 7 variable genes in 1,027 psoriatic patients and investigated its possible mechanism associated with psoriasis.MethodA total of 7 variable genes from 1,027 psoriatic patients were amplified and sequenced using the Sanger method. The mutation frequency was compared to that of non‐psoriatic individuals in Asia using information from databases.ResultsAmong the 7 investigated genes, the mutation frequency of ACOT12 (c.80A>G, 9.98% vs. 5.85%, p < .05) and CT62 (c.476C>T,15.8% vs. 9.93%, p < .05) was found to be significantly higher than among non‐psoriatic Asian individuals. The mutation frequencies of CASZ1(c.599T>G), SPRED1(c.155A>G), and ACOT12 (c.80A>G) differed significantly between the groups organized by medical history, PASI, and family history. SPRED1 gene variants (17.25% vs. 7.78%, p < .01) showed a stronger association with the family history group at the onset of psoriasis than with the no family history group.ConclusionsOur results provide a comprehensive correlation analysis of susceptibility genes in psoriasis patients. Clinical characteristics of patients play important roles in the development of psoriatic skin.
Over expression of METRN predicts poor clinical prognosis in colorectal cancer
Authors: Xu Xin , Zhang Chihao , Xia Yan , Yu Jiwei 
Published: December 2019

AbstractBackgroundThe role of meteorin (METRN) in colorectal cancer has not been reported previously. We aimed to explore the relationship between METRN and colorectal cancer (CRC) prognosis.MethodsData were retrieved from the Gene Expression Omnibus database. Gene expression values were log2 transformed and normalized by quantile normalization. Missing values were imputed with the R impute package. Differentially expressed genes were analyzed using the R limma package. METRN expression was compared between normal and CRC tissues and among different stages and subtypes of CRC. We assessed the relationship between METRN and KRAS/BRAF mutations in CRC. Five‐year overall (OS), disease‐free (DFS), and disease‐specific survival (DSS) rates were determined by Kaplan–Meier analysis and analyzed by log‐rank test.ResultsMETRN was expressed at a higher level in CRC (p = .0011) than in normal tissues, especially in advanced stages (p = .0343). METRN expression levels were higher in the MSI (dMMR) subtype (p < .001) and usually with BRAF mutations (p < .0001). METRN overexpression was associated with poor prognosis and low OS (p = .01014), DFS (p = .0146), and DSS (p < .0001) rates.ConclusionMETRN overexpression is a predictive factor for poor prognosis in patients with CRC.
The effect of a short educational intervention in social insurance medicine: A randomized controlled trial
Authors: Lännerström Linda , Holmström Inger K. , Wallman Thorne 
Published: December 2019

AbstractAimTo evaluate the effect of an educational intervention in social insurance medicine with Registered Nurses.DesignRandomized controlled trial.MethodsThe trial was performed in 20 primary healthcare centres in Central Sweden. The centres were randomly assigned as intervention or control. All Registered Nurses working with telephone nursing at the centres were invited (N = 114); out of these 100 agreed to participate and responded to a questionnaire at the beginning and end of the trial. Fourteen questions in the questionnaire dealt with professional background and were used as exposure variables and were analysed using nominal logistic regression.ResultsRegistered Nurses in the centres randomly assigned for the intervention experienced handling sick leave questions as less problematic after the intervention than those in the control group. This indicated that the intervention was associated with a positive effect. However, due to the rather small study population, the effect was inconclusive.
The Environmental Foodprint of Obesity
Authors: Magkos Faidon , Tetens Inge , Bügel Susanne Gjedsted , Felby Claus , Schacht Simon Rønnow , Hill James O. , Ravussin Eric , Astrup Arne 
Published: December 2019

Emissions of greenhouse gases (GHG) are linked to global warming and adverse climate changes. Meeting the needs of the increasing number of people on the planet presents a challenge for reducing total GHG burden. A further challenge may be the size of the average person on the planet and the increasing number of people with excess body weight. We used data on GHG emissions from various sources and estimated that obesity is associated with ~20% greater GHG emissions compared with the normal‐weight state. On a global scale, obesity contributes to an extra GHG emissions of ~49 megatons per year of CO2 equivalent (CO2eq) from oxidative metabolism due to greater metabolic demands, ~361 megatons per year of CO2eq from food production processes due to increased food intake, and ~290 megatons per year of CO2eq from automobile and air transportation due to greater body weight. Therefore, the total impact of obesity may be extra emissions of ~700 megatons per year of CO2eq, which is about 1.6% of worldwide GHG emissions. Inasmuch as obesity is an important contributor to global GHG burden, strategies to reduce its prevalence should prioritize efforts to reduce GHG emissions. Accordingly, reducing obesity may have considerable benefits for both public health and the environment.
Response of intraductal carcinoma of the prostate to androgen deprivation therapy predicts prostate cancer prognosis in radical prostatectomy patients
Authors: Kato Masashi , Hirakawa Akihiro , Kobayashi Yumiko , Yamamoto Akiyuki , Ishida Ryo , Kamihira Osamu , Sano Tomoyasu , Majima Tsuyoshi , Ishida Shohei , Funahashi Yasuhito , Sassa Naoto , Fujita Takashi , Matsukawa Yoshihisa , Hattori Ryohei , Gotoh Momokazu , Tsuzuki Toyonori 
Published: December 2019

AbstractBackgroundIntraductal carcinoma of the prostate (IDC‐P) has a poor prognosis and is thought to be completely resistant to current therapies, including androgen deprivation therapy (ADT). However, to date, there are no data showing direct evidence of such resistance.MethodsWe retrospectively evaluated 145 patients with high‐risk prostate cancer who underwent radical prostatectomy (RP) with neoadjuvant ADT between 1991 and 2005. All patient data were collected from slides prepared from needle biopsy (NB) samples of prostate tissue and RP specimens. Data were analyzed in terms of serum level of prostate specific antigen (PSA), Gleason score of NB samples, clinical T stage, the positive cancer core rate, maximum cancer extension rate, presence of Gleason pattern 5, and presence of IDC‐P in both NB samples and RP specimens.ResultsThe median initial PSA was 33.2 ng/mL (range, 2.4‐296 ng/mL), and the median follow‐up period was 109 months (range, 11‐257 months). The preoperative median ADT period was 4 months (range, 1‐20 months). IDC‐P was present in 53 patients (37%) in NB samples and 65 (45%) in RP. The patients were divided into three groups based on the presence or absence of IDC‐P in NB/RP samples (IDC‐P‐negative at biopsy: 92 cases, IDC‐P‐positive at biopsy with IDC‐P disappearance: 15 cases, and IDC‐P‐positive at biopsy with IDC‐P persistence: 38 cases). Overall, 28% of IDC‐P‐positive cases in NB samples showed the disappearance of IDC‐P at RP. IDC‐P persistence cases showed the poorest prognosis, while IDC‐P disappearance cases had a similar prognosis to that of IDC‐P‐negative at biopsy cases in terms of disease‐free survival, cancer‐specific survival, and overall survival (P = .0018, P = .0087, and P = .0034, respectively).ConclusionsSome cases with IDC‐P responded to ADT and demonstrated favorable clinical outcomes similar to those of cases without IDC‐P. These findings indicate that cases with IDC‐P are heterogeneous.
Orbital stabilization of nonlinear systems via the immersion and invariance technique
Authors: Ortega Romeo , Yi Bowen , Romero Jose Guadalupe , Astolfi Alessandro 
Published: December 2019

SummaryImmersion and invariance is a technique for the design of stabilizing and adaptive controllers and state observers for nonlinear systems. In all these applications the problem considered is the stabilization of equilibrium points. Motivated by some modern applications, we show that the technique can also be used to solve the problem of orbital stabilization, where the final objective is to generate periodic solutions that are attractive. The feasibility of our result is illustrated by means of some classical mechanical engineering and power electronics examples.
Using hydroacoustics to relate fluctuations in fish abundance to river restoration efforts and environmental conditions in the Penobscot River, Maine
Authors: Scherelis Constantin , Zydlewski Gayle Barbin , Brady Damian C. 
Published: December 2019

AbstractQuantifying change after large habitat restoration efforts is critical to assessing the effort's success. After river restoration activities, fish abundance is expected to increase and also fluctuates naturally by season and with environmental conditions. A side‐looking hydroacoustic system was used to estimate fish abundance in the Penobscot River, ME, from 2010 to 2016 during predam (2010–2013) and postdam (2014–2016) removal years during nonice periods. Automated data processing enabled continuous abundance estimates from fish tracks. A threefold increase in mean fish abundance was recorded after dam removal. A fourfold increase in median fish abundance occurred in the fall relative to spring and summer of the same year, regardless of dam presence. Interannual fish abundance in every season monitored increased at least twofold after dam removal. We related variability in fish abundance to tide, discharge, temperature, diurnal cycle, daylength, moon phase, and restoration activities (focusing on dam presence). Daylength corresponding to the fall and summer was the most important indicator for higher fish abundance. Fish abundance was generally greatest in the fall during outgoing tides at night, with lesser peaks occurring during the month of June at night. Before dam removal, fish abundance peaked when water temperature was less than 9.25°C, at night, during outgoing tides. After dam removal, fish abundance peaked when daylength was less than 11.3 hr, at night, during outgoing tides, when water temperature was above 4.56°C and no full moon was present. Peak fish abundance occurred during only 0.02–2.3% of the total time sampled. The threefold increase in fish abundance recorded after dam removal was observed despite yearly stocking efforts of adult alewife increasing 24% in postdam removal years. Finally, parallel studies of fish presence in the Penobscot River were used to compare the utility of this method as an indicator of fish abundance in response to dam removal.
Flossing DNA in a Dual Nanopore Device
Authors: Liu Xu , Zimny Philip , Zhang Yuning , Rana Ankit , Nagel Roland , Reisner Walter , Dunbar William B. 
Published: December 2019

AbstractSolid‐state nanopores are a single‐molecule technique that can provide access to biomolecular information that is otherwise masked by ensemble averaging. A promising application uses pores and barcoding chemistries to map molecular motifs along single DNA molecules. Despite recent research breakthroughs, however, it remains challenging to overcome molecular noise to fully exploit single‐molecule data. Here, an active control technique termed “flossing” that uses a dual nanopore device is presented to trap a proteintagged DNA molecule and up to 100's of back‐and‐forth electrical scans of the molecule are performed in a few seconds. The protein motifs bound to 48.5 kb λ‐DNA are used as detectable features for active triggering of the bidirectional control. Molecular noise is suppressed by averaging the multiscan data to produce averaged intertag distance estimates that are comparable to their known values. Since nanopore feature‐mapping applications require DNA linearization when passing through the pore, a key advantage of flossing is that trans‐pore linearization is increased to >98% by the second scan, compared to 35% for single nanopore passage of the same set of molecules. In concert with barcoding methods, the dual‐pore flossing technique could enable genome mapping and structural variation applications, or mapping loci of epigenetic relevance.
Typification of Linnaean specific names in the genus Campanula (Campanulaceae)
Authors: Ferrer‐Gallego P. Pablo 
Published: December 2019

AbstractThe lectotypification of nine Linnaean names in the genus Campanula (C. decurrens, C. erinoides, C. graminifolia, C. hederacea, C. hybrida, C. linifolia, C. mollis, C. thyrsoides, C. uniflora) is discussed. The designation of the nomenclatural types is based on the consultation of Linnaeus's original material and the literature cited in the respective protologues. The names are lectotypified using specimens from LINN except for C. erinoides, C. graminifolia, and C. hybrida, which are lectotypified by illustrations of Hermann (1687), Barrelier (1714), and Morison (1680), respectively. An epitype is designated for C. graminifolia due to ambiguity in the interpretation of the lectotype.
Demotivating factors affecting the implementation of ISO 14001:2015 in Malaysia
Authors: Sorooshian Shahryar , Yee Lee Sue 
Published: December 2019

AbstractIndustrialization has brought with it environmental problems and the consequences of pollution, which has been affecting the world for decades. Immediate action is required to raise industry's awareness of its social responsibilities toward the environment. However, experience shows that companies that have obtained International Organization of Standardization (ISO) 14001:2015 certifications in Malaysia occupy but a small niche among the country's businesses. The purpose of this study is to assess the list of barriers and challenges to implementing and obtaining certifications under the ISO 14001:2015 Environmental Management System (EMS) by Malaysian firms. In addition, this study will rank these factors relative to their importance. This study is aimed at EMS experts at the Scientific and Industrial Research Institute of Malaysia (SIRIM QAS International Sdn. Bhd.). The study uses mathematical pairwise comparisons to generate the list of critical challenges and barriers. Therefore, the study is expected to raise environmental awareness among Malaysia's industries regarding the adoption of ISO 14001:2015 standards. Furthermore, the study provides a guideline for Malaysia's industries and policy‐makers to provide them with a better understanding of the barriers and challenges that companies face in implementing ISO 14001:2015 EMS, and at the same time, help them understand the need to eliminate the difficulties of standard implementation.
Sphingosine is able to prevent and eliminate Staphylococcus epidermidis biofilm formation on different orthopedic implant materials in vitro
Authors: Beck Sascha , Sehl Carolin , Voortmann Sylvia , Verhasselt Hedda Luise , Edwards Michael J. , Buer Jan , Hasenberg Mike , Gulbins Erich , Becker Katrin Anne 
Published: December 2019

AbstractPeriprosthetic infection (PPI) is a devastating complication in joint replacement surgery. On the background of an aging population, the number of joint replacements and associated complications is expected to increase. The capability for biofilm formation and the increasing resistance of different microbes to antibiotics have complicated the treatment of PPI, requiring the need for the development of alternative treatment options. The bactericidal effect of the naturally occurring amino alcohol sphingosine has already been reported. In our study, we demonstrate the antimicrobial efficacy of sphingosine on three different strains of biofilm producingStaphylococcus epidermidis, representing one of the most frequent microbes involved in PPI. In an in vitro analysis, sphingosine’s capability for prevention and treatment of biofilm-contamination on different common orthopedic implant surfaces was tested. Coating titanium implant samples with sphingosine not only prevented implant contamination but also revealed a significant reduction of biofilm formation on the implant surfaces by 99.942%. When testing the antimicrobial efficacy of sphingosine on sessile biofilm-grownStaphylococcus epidermidis, sphingosine solution was capable to eliminate 99.999% of the bacteria on the different implant surfaces, i.e., titanium, steel, and polymethylmethacrylate. This study provides evidence on the antimicrobial efficacy of sphingosine for both planktonic and sessile biofilm-grownStaphylococcus epidermidison contaminated orthopedic implants. Sphingosine may provide an effective and cheap treatment option for prevention and reduction of infections in joint replacement surgery.Key messages• Here we established a novel technology for prevention of implant colonization by sphingosine-coating of orthopedic implant materials.• Sphingosine-coating of orthopedic implants prevented bacterial colonization and significantly reduced biofilm formation on implant surfaces by 99.942%.• Moreover, sphingosine solution was capable to eliminate 99.999% of sessile biofilm-grownStaphylococcus epidermidison different orthopedic implant surfaces.