bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERAMALAN JUMLAH PENUMPANG PESAWAT DI BANDARA INTERNASIONAL AHMAD YANI DENGAN METODE HOLT WINTER’S EXPONENTIAL SMOOTHING DAN METODE EXPONENTIAL EMOOTHING EVENT BASED
Authors: Sofiana Sofiana , Suparti Suparti , Hakim Arief Rachman , Triutami Iut 
Published: December 2020

Forecasting the number of airplane passengers can be a consideration for the airline at Ahmad Yani International Airport related with addition of extra flight. The number of airplane passengers can be influenced by certain seasonal or special events. The seasonal influences can be known through historical data patterns and if there is a seasonal pattern, the Holt Winter’s Exponential Smoothing method can be used. Exponential Smoothing Event Based (ESEB) forecasting method can be use to see the special events that effect the number of airplane passengers at Ahmad Yani International Airport. After compared, the Holt Winter’s Exponential Smoothing method is a better method of forecasting the number of airplane passengers at Ahmad Yani International Airport because it has a smaller error value, namely the MSE value and the MAPE value than the Exponential Smoothing Event Based (ESEB)method. The MAPE and MSE values be produced from the best method each of 5,644139% and 619,998,718 .Keywords : Airplane Passengers, Seasonal Pattern, Special Event, Exponential Smoothing Event Based , Holt Winter’s Exponential Smoothing.
Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media
Authors: McLaren Son H. , Cruz Andrea T. , Yen Kenneth , Lipshaw Matthew J. , Bergmann Kelly R. , Mistry Rakesh D. , Gutman Colleen K. , Ahmad Fahd A. , Pruitt Christopher M. , Thompson Graham C. , Steimle Matthew D. , Zhao Xian , Schuh Abigail M. , Thompson Amy D. , Hanson Holly R. , Ulrich Stacey L. , Meltzer James A. , Dunnick Jennifer , Schmidt Suzanne M. , Nigrovic Lise E. , Waseem Muhammad , Velasco Roberto , Ali Samina , Cullen Danielle L. , Gomez Borja , Kaplan Ron L. , Khanna Kajal , Strutt Jonathan , Aronson Paul L. , Taneja Ankita , Sheridan David C. , Chen Carol C. , Bogie Amanda L. , Wang Aijin , Dayan Peter S. ,   ON BEHALF OF THE PEDIATRIC EMERGENCY MEDICINE COLLABORATIVE RESEARCH COMMITTEE
Published: December 2020

OBJECTIVES:To determine the prevalence of invasive bacterial infections (IBIs) and adverse events in afebrile infants with acute otitis media (AOM).METHODS:We conducted a 33-site cross-sectional study of afebrile infants ≤90 days of age with AOM seen in emergency departments from 2007 to 2017. Eligible infants were identified using emergency department diagnosis codes and confirmed by chart review. IBIs (bacteremia and meningitis) were determined by the growth of pathogenic bacteria in blood or cerebrospinal fluid (CSF) culture. Adverse events were defined as substantial complications resulting from or potentially associated with AOM. We used generalized linear mixed-effects models to identify factors associated with IBI diagnostic testing, controlling for site-level clustering effect.RESULTS:Of 5270 infants screened, 1637 met study criteria. None of the 278 (0%; 95% confidence interval [CI]: 0%–1.4%) infants with blood cultures had bacteremia; 0 of 102 (0%; 95% CI: 0%–3.6%) with CSF cultures had bacterial meningitis; 2 of 645 (0.3%; 95% CI: 0.1%–1.1%) infants with 30-day follow-up had adverse events, including lymphadenitis (1) and culture-negative sepsis (1). Diagnostic testing for IBI varied across sites and by age; overall, 278 (17.0%) had blood cultures, and 102 (6.2%) had CSF cultures obtained. Compared with infants 0 to 28 days old, older infants were less likely to have blood cultures (P &lt; .001) or CSF cultures (P &lt; .001) obtained.CONCLUSION:Afebrile infants with clinician-diagnosed AOM have a low prevalence of IBIs and adverse events; therefore, outpatient management without diagnostic testing may be reasonable.
A Randomized Trial of Strategies Using Darbepoetin Alfa To Avoid Transfusions in CKD
Authors: Toto Robert , Petersen Jeffrey , Berns Jeffrey S. , Lewis Eldrin Foster , Tran Qui , Weir Matthew R. 
Published: December 2020

Background
Exposure to high doses or a high cumulative dose of erythropoiesis-stimulating agents (ESAs) may contribute to cardiovascular events in patients with CKD and anemia. Whether using a low fixed ESA dose versus dosing based on a hemoglobin-based, titration-dose algorithm in such patients might reduce risks associated with high ESA doses and decrease the cumulative exposure—while reducing the need for red blood cell transfusions—is unknown.

Methods
In this phase-3, randomized trial involving 756 adults with stage-3 to -5 CKD and anemia, we evaluated incidence of red blood cell transfusions for participants randomized to receive darbepoetin given as a fixed dose (0.45 µg/kg every 4 weeks) versus administered according to a hemoglobin-based, titration-dose algorithm, for up to 2 years. Participants received transfusions as deemed necessary by the treating physician.

Results
There were 379 patients randomized to the fixed-dose group, and 377 to the titration-dose group. The percentage of participants transfused did not differ (24.1% and 24.4% for the fixed-dose and titration-dose group, respectively), with similar time to first transfusion. The titration-dose group achieved significantly higher median hemoglobin (9.9 g/dl) compared with the fixed-dose group (9.4 g/dl). The fixed-dose group had a significantly lower median cumulative dose of darbepoetin (median monthly dose of 30.9 µg) compared with the titration-dose group (53.6 µg median monthly dose). The FD and TD group received a median (Q1, Q3) cumulative dose per 4 weeks of darbepoetin of 30.9 (21.8, 40.0) µg and 53.6 (31.1, 89.9) µg, respectively; the median of the difference between treatment groups was −22.1 (95% CI, −26.1 to −18.1) µg.

Conclusions
These findings indicate no evidence of difference in incidence of red blood cell transfusion for a titration-dose strategy versus a fixed-dose strategy for darbepoetin. This suggests that a low fixed dose of darbepoetin may be used as an alternative to a dose-titration approach to minimize transfusions, with less cumulative dosing.
Soluções projetuais do Arquiteto Milton Monte para Amazônia no contexto da sustentabilidade
Authors: Arraes Hugo Felipe de Souza , Perdigão Ana Kláudia de Almeida Viana 
Published: December 2020

A sustentabilidade mostra-se na obra de Milton Monte com a busca de produção arquitetônica relacionada aos aspectos ambientais e culturais da Amazônia. Desse modo o estudo da trajetória do arquiteto e suas decisões projetuais permite uma melhor compreensão dos fundamentos de uma arquitetura comprometida com o lugar amazônico. Este artigo apresenta a produção arquitetônica na Amazônia por meio de um arquiteto de grande importância na medida em que tornou possível um vocabulário único em suas obras que podem traduzir um pensamento projetual refinado para apresentar uma linguagem de projeto que demonstra a identidade profissional do Arq. Milton Monte como uma alternativa a ser utilizada no ensino como referência operativa prática. Para isso, foi realizada uma breve sistematização da trajetória do arquiteto e uma análise que busca na sua produção a intencionalidade de se vincular sua obra ao lugar amazônico. Os esquemas e análises apresentaram puderam atestar a criação de uma arquitetura correlacionada ao lugar amazônico e de grande operação cognitiva.
Índice de avermelhamento, densidade e umidade do solo em áreas de borda em remanescentes florestais sob influência antrópica.
Authors: Silva Gabrielle Stevanato da , Longo Regina Márcia 
Published: December 2020

O presente trabalho foi realizado na área de relevante interesse ecológico Mata de Santa Genebra em Campinas, interior de São Paulo. A área está localizada em uma região com elevados interferentes antrópicos. O objetivo do trabalho foi analisar o índice de avermelhamento, densidade do solo e umidade como indicadores de degradação ambiental, associando conhecimentos teóricos, atividades em campo e coleta de amostras do solo, análises laboratoriais e crítica dos resultados utilizando métodos estatísticos. Para a realização das análises com o solo coletado no remanescente foi utilizado o manual de métodos de análise do solo da EMBRAPA. Os resultados obtidos apontaram que a área sofre influência externa das atividades desenvolvidas no entorno de sua borda. As áreas que apresentaram, de acordo com os resultados obtidos nas análises, a maior influência das atividades realizadas no entorno do fragmento foram as que fazem interface com a área compactada e com a estrada por apresentarem baixa umidade e densidade do solo quando comparadas ao interior da mata, devido a compactação do solo decorrente do tráfego excessivo na área.
THE FUTURE ROLE OF DESTINATION MANAGEMENT ORGANIZATIONS: THEORIES AND METHODOLOGICAL TOOLS
Authors: Katemliadis Iordanis 
Published: December 2020

The aim of this paper is to review the existing literature regarding Destination Management Organizations (DMO) and the various stakeholders that the destination consists of. The paper covers the preliminary stage of the whole research which will cover existing theories such as business ecosystem and stakeholder theories and it will also suggest for future research a systemic approach towards destinations in order to improve their effectiveness and efficiency. Finally, it will examine the various methodological tools such as benchmarking and EFQM that exist and can be used in order to research the topic. The aim is to identify the need for future research to develop an optimal model of effective DMO.
Maternal and fetal characteristics associated with meconium-stained amniotic fluid
Authors: Patel Smeet , Patel Babulal , Shah Akshay , Jani Shashwat , Jani Chinmay 
Published: December 2020

Black-green colored odorless material known as meconium is physiologically passed by new born babies with in 48 hours of birth. Presence of meconium in the amniotic fluid could be a dangerous condition. It may expose the baby to multiple condition depending upon the amount of meconium entering in to the respiratory track of the baby. The knowledge of association of various maternal and fetal associated factors with meconium aspiration syndrome is of immense importance for appropriate clinical judgments and decisions.The aim of the present study was to study various maternal and fetal parameters associated with meconium stained amniotic fluid.The present study was a prospective observational study. It was conducted in the Obstetrics and Gynecology department of Tertiary Hospital & Medical Collage & Research Centre, Ahmedabad, Gujarat, India during May 2016 to May 2018 on 200 laboring mothers with meconium stained amniotic fluid who delivered or underwent cesarean section in the institute were included in the study. Majority of them were between 20–30 years of age (59%). The women between 31–35 years of age were 27%. Participants either &#60;20 years or &#62;35 years were 9% and 5% respectively. There were 82 patients who had grade I MSL, 63 patient who had grade II MSL whereas 55 patients who had grade III MSL. Out of 200, there were 196 women who were having associated risk factors like prolonged labour, PROM, hypertension, postdatism, GDM, IUGR and anaemia. MSL as well as MAS has been strongly associated with the parity of the mother. It was also observed that patients who’s age was greater than 35 yrs. All (100%) presented with grade 3 MSL. Fetus whose gestational age was greater than 40 weeks has fewer chances of co-morbidities.It was concluded in the present study that multiparity, higher maternal age, presence of Maternal Risk Factors, C-section, IUGR, oligo-hydraminos, post-datism, GDM, non-reactive CTG, prolonged labor and PROM had significant association with higher grades of meconium stained Liquor. It is strongly recommend that in such patients early and appropriate care along with constant monitoring can prove to be highly beneficial.
Significance of stress assessment: cross sectional study of 1000 pregnant women from India
Authors: Singh Amrita , Shelkar Priyanka , Singh Kanishk , Anjankar Shailendra 
Published: December 2020

Maternal stress has been believed to have effect on the developing embryo and foetus in womb. Measuring and addressing stress is not yet part of structured antenatal protocols for pregnant women. The current study focuses on the association of perceived stress among pregnant women on maternal and foetal outcome.This was an observational cross-sectional study on 1000 pregnant women done during the period Nov 2010 to Nov 2012 at Fernandez Hospital, Hyderabad, India. Associations between maternal stress by PSS score and mode of delivery, duration of labour, and foetal outcomes were assessed. Statistical tools like K-Smirnov test, Fishers exact and Kruksal Wallis test were used wherever appropriate.Participant mothers ranged in age from 18 to 42 years. 41.4% were postgraduate. 6.6%, 86.6%, 6.8% had preterm, term and post term deliveries respectively. 799, 102, 95 were average for gestational age babies, large for gestational age babies and small for gestational age babies respectively. PSS (Perceived Stress Scale) questionnaire mean score was 30.73 with standard deviation of 2.44. There was no statistical difference with different modes of deliveries and various neonatal outcomes with third trimester PPS stress score in this study.Adequate counselling is essential to reduces the maternal stress at various stages of pregnancy and delivery. Assessment of stress should be an integral part of antenatal care.
Frequency of DNMT3A Mutations in Patients with Acute Leukemia in Mashhad
Authors: Bagheri Parisa , Zaker Farhad , Sadeghian Mohammad Hadi , Namjoo Soodeh , Hajebi Khaniki Saeedeh , Chehreghani Zahra , Sheikhi Maryam , Ayatollahi Hossein 
Published: December 2020

Background and Aims: DNA methyltransferase3A (DNMT3A) is necessary for the adjustment of gene expression, and the mutations in the DNMT3A gene are reported in a variety of leukemia cases. DNMT3A mutations are during cancer progression and cause poor prognosis in many leukemias. Thus, this gene can be a target for new treatments. This study aimed to examine the distribution of DNMT3A mutations in Iranian acute leukemia patients.
Materials and Methods: In this study, diagnostic samples from 45 patients with de novo acute leukemia, including 22 acute myeloid leukemia (AML) patients, and 23 acute leukemia lymphoblastic (ALL) patients were screened, from April 2017 to March 2018 for the incidence of DNMT3A mutations by polymerase chain reaction and direct sequencing.
Results: A total of 2 (9.1%) AML cases and 1 (4.34%) ALL cases were found to have the DNMT3A R882H mutation. It was found that a total of 22.7% and 21.7% of patients with AML and ALL had polymorphism rs368516543, respectively. DNMT3A mutations were considerably associated with higher age in AML patients.
Conclusions: The findings suggest that the DNMT3A mutations are probably a new biomarker in the early examination and treatment of acute leukemia, even though further studies are needed.
Effect of Peganum Harmala Seeds Extract on Nitric Oxide in U937 Monocytes and Macrophages
Authors: Rahmati Nima , Hajighasemi Fatemeh 
Published: December 2020

Background and Aims: Nitric oxide (NO) has an essential role in inflammation and has been related to pathogenesis and the progress of numerous inflammatory-based diseases, including some cancers. Peganum harmala (P. harmala) is a medicinal plant used for the treatment of numerous diseases such as several infections. Also, anti-inflammatory effects of P. harmala extracts and its derivatives (harmaline and harmine) by suppressing myeloperoxidase, NO, and other mediators have been demonstrated in vivo. In this study, the effect of P. harmala seeds aqueous extract on NO production in U937 monocytic cells and peritoneal macrophages has been evaluated in vitro.
Materials and Methods: U937 and mice peritoneal macrophages were cultured in Roswell Park Memorial institute-1640 with 10% fetal calf serum. Then, the cells at the logarithmic growth phase were incubated with different concentrations of aqueous extract of P. harmala seeds (0.1-1 mg/ml) for 24 hours. Next, NO production was assessed by the Griess method in the culture medium.
Results: P. harmala seeds aqueous extract did not significantly affect lipopolysaccharide-induced NO production in U937 cells and peritoneal macrophages after 24 hours incubation time compared with untreated control cells.
Conclusion: These results suggest that the anti-inflammatory effects of P. harmala may be mediated through NO-independent mechanism(s). However, further studies are warranted to define the P. harmala aqueous extract impact on NO expression in other related normal and cancerous cells.
State Response to the COVID-19 Pandemic
Authors: Dugis (Scopus ID: 57201258125) Vinsensio 
Published: December 2020

In this edition, Global Strategis specifically presents articles about the experiences of seventeen different countries from various regions in the world, on how their respective governments respond to the COVID-19 pandemic. The focus was on the first six months of 2020 as this period (January to June 2020) is considered a critical moment. It was during this period the world realizes that it is faced with a global health crisis, enforcing every country to 'fast learning' confronting this completely new pandemic, and hence to determine the most appropriate response in confronting the difficult choice between saving people's lives or preventing the country's economic crisis. Different experiences of each country seem to suggest that above various variables affecting each of them, the initial attitude of their respective governments in assessing the deadly level of COVID-19 pandemic and the speed to act according to what is most needed are crucial factors influencing the relative success or not of the response of their respective governments. When knowing the initial information about the transmission of the virus that originated in Wuhan, China, to what extent the governments of each country see this as a force that potentially deadly outbreak? Keywords: Global Health Crisis, Pandemic Covid-19, State Response.Pada edisi ini, Global Strategis secara khusus menghadirkan tulisan tentang pengalaman tujuh belas negara dari kawasan dunia yang berbeda, bagaimana pemerintah mereka merespons pandemi COVID-19. Fokus kajian pada periode enam bulan pertama tahun 2020 karena periode ini (Januari sampai dengan Juni 2020) dianggap momen kritis. Pada periode inilah dunia mengakui mulai sedang dihadapkan pada situasi krisis kesehatan global, memaksa setiap negara ‘belajar cepat’ menghadapi pandemi yang sama sekali baru ini, untuk selanjutnya secara tepat pula menentukan respons yang paling sesuai menghadapi pilihan sulit antara menyelamatkan nyawa penduduk atau mencegah krisis ekonomi negara. Pengalaman berbeda dari berbagai negara nampaknya membawa ke suatu kesimpulan bahwa di atas kompleksitas variabel yang masing-masing memengaruhi pilihan kebijakan, nampaknya sikap awal pemerintah di dalam menilai tingkat ‘mematikan’ wabah COVID-19 serta kecepatan bertindak atas dasar kebutuhan masing-masing menjadi faktor krusial menentukan keberhasilan masing-masing negara. Ketika mengetahui informasi awal tentang adanya penularan virus yang bermula dari Wuhan, China ini, sejauh mana pemerintah masing-masing negara melihat ini sebagai kekuatan yang berpotensi sebagai wabah mematikan? Kata-kata Kunci: Krisis Kesehatan Global, Pandemi COVID-19, Respon Negara.
Deliberate Negligence: Bolsonaro and Brazil’s Failure in Response to COVID-19 Pandemic
Authors: Santoso Yohanes William 
Published: December 2020

Brasil merupakan negara dengan kasus positif COVID-19 tertinggi kedua di dunia, setelah Amerika Serikat. Kasus penularan dan kematian yang tinggi membuat Brasil dapat dikatakan gagal dalam mencegah penyebaran COVID-19. Terdapat beberapa faktor yang berpengaruh dalam kegagalan upaya Brasil merespon pandemi ini. Salah satunya adalah karena adanya informasi dan instruksi yang berbeda antara Presiden Bolsonaro dengan gubernur-gubernurnya. Tulisan ini bertujuan untuk mengkaji respon Brasil dalam mengatasi pandemi COVID-19 dari rentang waktu sejak kasus pertama pada bulan Februari hingga bulan Juli 2020, serta menjelaskan alasan kegagalan tersebut. Argumen utama penulis adalah kegagalan Brasil disebabkan oleh adanya gejolak dalam politik domestik Brasil, dan kondisi sosial ekonomi di Brasil. Gejolak politik domestik tersebut dibagi menjadi dua yaitu gejolak di tingkat nasional: antara Presiden Bolsonaro dan menteri kesehatannya; dan gejolak di tingkat lokal: antara Presiden Bolsonaro dengan para gubernur negara bagian. Dari segi ekonomi, kondisi Brasil yang masih berusaha memulihkan perekonomian membuat pemerintahan Bolsonaro seolah sengaja melalaikan tanggung jawab untuk mengatasi penyebaran COVID-19. Sementara dari segi sosial, ketimpangan yang ada di Brasil membuat masyarakat yang tinggal di daerah-daerah miskin menjadi paling beresiko tertular karena tidak adanya infrastruktur sanitasi yang memadai. Kata-kata kunci: COVID-19, Brasil, Bolsonaro, kelalaian Brazil is a country with the second highest positive cases of COVID-19 in the world, after the United States. The high number of infected and death cases makes Brazil fail to prevent the spread of COVID-19. There are several factors contributed to Brazil's failure to respond the pandemic. One of the reasons is because of the information and differences between President Bolsonaro and his governors. This paper aims to examine Brazil's response in overcoming the COVID-19 pandemic from the timeframe from the first case in February to July 2020, and to explain the reasons for this failure. The author’s main argument is that Brazil's failure was caused by the turmoil in domestic politics and the socio-economic conditions in Brazil. Domestic political turmoil is divided into two, namely turmoil at the national level: between President Bolsonaro and his ministers of health; and turmoil at the local level: between President Bolsonaro and state governors. From the economy point of view, Brazil's condition, which is still in recovery, has made the Bolsonaro administration seem to have deliberately neglected its responsibility to contain the spread of COVID-19. Meanwhile, from a social perspective, the existing inequality in Brazil put people living in poorest regions at the highest risk of infection due to the absence of adequate sanitation infrastructure. Keywords: COVID-19, Brazil, Bolsonaro, negligence
Karakterisasi Pasta Gigi Berbahan Abrasif Hidroksiapatit (HAp)
Authors: Gintu Agung Rimayanto , Kristian Elizabeth Betty Elok , Martono Yohanes 
Published: December 2020

Tootpaste was a product for dental care to clean, beautify and replace the minerals decay from the dent surface. To prevent the damage of the mineral layers on the surface, added the remineralitation compounds in the formula of the toothpaste. The remineralitation agents commonly add was CaCO3 and CaPO4, during the technological development the calcium compounds added was calcium in nano size like Hydroxyapatite (HAp). In this study produced the contains abrasive HAp and CaCO3 with the mix ratio CaCO3, 50:50 (HAp:CaCO3) and HAp. The characterization to the toothpaste with CaCO3 abrasive showed the Calcium contains 21,10 ± 0,0577%; dispersibility 936,37 ± 39,42gcm/s; pH 8,3 ± 0,00; and viscosity 25 ± 0,00 P.a. The toothpaste with CaCO3:HAp (50:50) abrasive showed the Calcium contains 27,03 ± 0,0333%; dispersibility 931,93 ± 22,62gcm/s; pH 8,8 ± 0,00; and viscosity 27 ± 0,00 P.a. The toothpaste with HAp abrasive showed the Calcium contains 27,67 ± 0,0882%; dispersibility 987,33 ± 39,50gcm/s; pH 8,9 ± 0,00; and viscosity 27,5 ± 0,00 P.a. The contamination of microbiology did not found in all of the toothpastes along the storage. Based on the entire organoleptic test against the toothpastes, the formula of toothpaste with the mix of CaCO3:HAp was les liked.