bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and benefits of automated red cell depletion‐exchange compared to standard exchange in patients with sickle cell disease undergoing chronic transfusion
Authors: Ziemba Yonah , Xu Cindy , Fomani Katayoun M. , Nandi Vijay , Yuan Tiejun , Rehmani Shiraz , Sachais Bruce S. , Appiah‐Kubi Abena O. , Aygun Banu , Louie James E. , Shi Patricia A. 
Published: December 2020

AbstractBackgroundThe Spectra Optia allows automated performance of red blood cell reduction and isovolemic hemodilution (IHD) prior to standard red cell exchange (RCE), and is primarily intended for patients with sickle cell disease (SCD) undergoing chronic RCE. Data on the safety of inducing transient further anemia and the benefits of IHD‐RCE is limited and occasionally contradictory.Study Design and MethodsIn this retrospective crossover analysis of six patients with SCD who underwent chronic exchange with standard RCE (Cobe Spectra) followed by IHD‐RCE (Spectra Optia), we compared safety and benefit outcomes with IHD‐RCE vs standard RCE.ResultsThere were statistically but not clinically significant drops in blood pressure in the post‐IHD phase. With IHD‐RCE, there were significant reductions in red blood cell (RBC) usage and/or lower fraction of cells and significant increases in postprocedure hematocrit (Hct) associated with increased preprocedure Hct. There were no differences achieved in the time interval between procedures or in the net RBC gain with IHD‐RCE. Overall, there were also no significant differences in pre‐ and postprocedure percentage of hemoglobin S, reticulocyte count, interval daily hemoglobin A decrement, or postprocedure white blood cell, neutrophil, or platelet counts.ConclusionsOur study supports that IHD‐RCE can be safely used in patients with stroke risk and compared to standard RCE, results in benefits of lower RBC usage and/or fraction of cells remaining and higher postprocedure Hct associated with higher preprocedure Hct. These findings support wider use of IHD‐RCE, especially in the current environment with reduced availability of minority units.
CHRISTIANITY, SCIENCE, AND THREE PHASES OF BEING HUMAN
Authors: Reichenbach Bruce R. 
Published: December 2020

AbstractThe alleged conflict between religion and science most pointedly focuses on what it is to be human. Western philosophical thought regarding this has progressed through three broad stages: mind/body dualism, Neo‐Darwinism, and most recently strong artificial intelligence (AI). I trace these views with respect to their relation to Christian views of humans, suggesting that while the first two might be compatible with Christian thought, strong AI presents serious challenges to a Christian understanding of personhood, including our freedom to choose, moral choice itself, self‐consciousness, and the relevance of God to our beginning, being, and ending.
Hydrocracking of C5-Deasphalted Oil:
Effects of H2 and Dispersed Catalysts
Authors: Nguyen Ngoc Thuy , Kang Ki Hyuk , Seo Pill Won , Kang Narae , Pham Duy Van , Kim Gyoo Tae , Park Sunyoung 
Published: December 2020

Abstract
Thermal cracking of C5-deasphalted oil
(C5-DAO) was performed in a batch reactor at 410°C in
the absence and presence of H2 gas and catalysts. Coke
was formed during the thermal cracking of C5-DAO even
though the feed contained no asphaltenes. Although H2
suppressed asphaltene formation and decreased the coke yield, coke was still
formed in the absence of a catalyst. A slurry-phase dispersed catalyst inhibited
the transformation of resins into heavier fractions and facilitated <1 wt %
asphaltene yield with no coke formation even under high conversion conditions.
The main function of the catalyst was the facilitation of hydrogenation
reactions and the stabilization of free radicals, leading to liquid production
by inhibiting coke formation. Consequently, the product quality, in terms of
hydrogen to carbon ratio and microcarbon residue and S contents, was enhanced by
catalytic hydrocracking.
The Supposed Material Cause in Posterior Analytics 2.11
Authors: Stein Nathanael 
Published: December 2020

Abstract
Aristotle presents four causes in Posterior Analytics 2.11, but where we expect matter we find instead the confusing formula, ‘what things being the case, necessarily this is the case’, and an equally confusing example. Some commentators infer that Aristotle is not referring to matter, others that he is but in a non-standard way. I argue that APo. 94a20-34 presents not matter, but determination by general features or facts, including facts about something’s genus. The closest connection to matter is Aristotle’s view that the relation between genus and species is analogous to that between matter and a hylomorphic compound.
Trojan Horses: The Counterintuitive Use of Dinah, Helen, and Goliath in Joseph and Aseneth
Authors: Kochenash Michael 
Published: December 2020

Abstract
A primary theme of the first story in Joseph and Aseneth (Jos. Asen. 1–21) is the conversion of an Egyptian to the worship of the living God, motivated by romantic attraction. In this respect, Joseph and Aseneth is one among many ancient novelistic writings to use a story about intermarriage, in this case the marriage of a Hebrew to an Egyptian, as a means to explore themes related to hybridity. Though different in tone, I propose that the second story (Jos. Asen. 22–29) is equally concerned with hybridity and that it can likewise be read as expressing an intercultural sensibility that is open to gentile incorporation and intermarriage through its imitation—and subversion—of literary models from two different cultural domains, the Jewish Scriptures (the rape of Dinah; the slaying of Goliath) and classical Greek literature (the abduction of Helen).
Multiple Endocrine Tumors Associated with Germline MAX Mutations: Multiple Endocrine Neoplasia Type 5?
Authors: Seabrook Amanda J , Harris Jessica E , Velosa Sofia B , Kim Edward , McInerney-Leo Aideen M , Dwight Trisha , Hockings Jason I , Hockings Nicholas G , Kirk Judy , Leo Paul J , Love Amanda J , Luxford Catherine , Marshall Mhairi , Mete Ozgur , Pennisi David J , Brown Matthew A , Gill Anthony J , Hockings Gregory I , Clifton-Bligh Roderick J , Duncan Emma L 
Published: December 2020

Abstract

Context
Pathogenic germline MAX variants are associated with pheochromocytoma and paraganglioma (PPGL), pituitary neuroendocrine tumors and, possibly, other endocrine and nonendocrine tumors.

Objective
To report 2 families with germline MAX variants, pheochromocytomas (PCs) and multiple other tumors.

Methods
Clinical, genetic, immunohistochemical, and functional studies at University hospitals in Australia on 2 families with germline MAX variants undergoing usual clinical care. The main outcome measures were phenotyping; germline and tumor sequencing; immunohistochemistry of PC and other tumors; functional studies of MAX variants.

Results
Family A has multiple individuals with PC (including bilateral and metastatic disease) and 2 children (to date, without PC) with neuroendocrine tumors (paravertebral ganglioneuroma and abdominal neuroblastoma, respectively). One individual has acromegaly; immunohistochemistry of PC tissue showed positive growth hormone–releasing hormone staining. Another individual with previously resected PCs has pituitary enlargement and elevated insulin-like growth factor (IGF-1). A germline MAX variant (c.200C&gt;A, p.Ala67Asp) was identified in all individuals with PC and both children, with loss of heterozygosity in PC tissue. Immunohistochemistry showed loss of MAX staining in PCs and other neural crest tumors. In vitro studies confirmed the variant as loss of function. In Family B, the proband has bilateral and metastatic PC, prolactin-producing pituitary tumor, multigland parathyroid adenomas, chondrosarcoma, and multifocal pulmonary adenocarcinomas. A truncating germline MAX variant (c.22G&gt;T, p.Glu8*) was identified.

Conclusion
Germline MAX mutations are associated with PCs, ganglioneuromas, neuroblastomas, pituitary neuroendocrine tumors, and, possibly, parathyroid adenomas, as well as nonendocrine tumors of chondrosarcoma and lung adenocarcinoma, suggesting MAX is a novel multiple endocrine neoplasia gene.
Chemical Insights into Liquid-Liquid Phase Separation in Molecular Biology
Authors: Kamimura Yugo R , Kanai Motomu 
Published: December 2020

Abstract
Liquid-liquid phase separation (LLPS) in living organisms is a recently emerging biologic principle that may dramatically alter current perceptions of cellular systems. Various proteins, RNAs, and other biomolecules undergo LLPS, exhibiting various cellar functions. The field is still immature, however, there is no consensus regarding the basic experimental techniques used for characterizing the phenomenon, knowledge of the physicochemical basis driving and regulating LLPS in cells is insufficient, and very little is known about potential chemical interventions for LLPS. Addressing these deficiencies requires chemical approaches, and will markedly advance drug discovery, molecular biology, and medicine. Here, we introduce the basic biology of LLPS and present challenges in the field from a chemical viewpoint.
Üriner Sistem Taşlarında Önceki Müdahalelerin Preoperatif Faktörlere ve Postoperatif Sonuçlara Etkisi: İki Merkezli Analiz
Authors: ÇAKICI Mehmet Çağlar , SANDIKÇI Fatih , İPLİKÇİ Ayberk , UÇAR Taha , ÇİMEN Sertaç , KARAKOYUNLU Nihat , ATİS Gokhan , YILDIRIM Asıf 
Published: December 2020

Amaç: Bu çalışmada üriner sistem taşı olup müdahale öyküsü bulunanlarla primer hastaların preoperatif ve peroperatif sonuçlarını karşılaştırmayı amaçladık.
Gereç ve Yöntemler: Lokal etik kurul onayı alındıktan sonra Ekim 2018–Ocak 2019 tarihlerinde her iki merkezde üriner sistem taşı nedeniyle ameliyat edilen hastalar içerisinden şok dalga litotripsi veya taş cerrahisi öyküsü olmayan 152 primer hasta Grup 1, müdahale öyküsü olan 232 hasta ise Grup 2 olarak çalışmaya alındı.
Bulgular: Demografik özellikler iki grupta benzer bulundu. Düşük sosyoekonomik düzey ve düşük eğitim düzeyi olanlar büyük çoğunluğu oluşturmaktaydı. Son 1 yılda yapılan BT görüntüleme sayısı sekonder hastalarda istatistiksel olarak daha fazlaydı (p
Platin Grubu Metal İçeren Demir Matının Oksidatif Koşullarda Çözeltiye Alınmasının İncelenmesi
Authors: MORCALİ M.hakan , AKSU Merve 
Published: December 2020

Özellikle kara taşıtlarında fosil bazlı yakıtların yakılması sonucu oluşan tehlikeli gazların (CO, NOx, hidrokarbon (HC)) daha az zararlı gazlara (CO2, N2, H2O) dönüştürülmesinde katalitik dönüştürücüler kullanılmaktadır. Bu kimyasal dönüşüm platin grubu metaller (PGM) varlığında çok kısa sürede yüksek verimle gerçekleşmektedir. Dünya’da PGM konusunda yaşanan arz-talep dengesizliği sebebiyle her türlü PGM ihtiva eden atıktan değerli metallerin geri kazanımı çok büyük önem arz etmektedir.
Bu bilimsel çalışmada, katalitik dönüştürücülerden katı-katı ekstraksiyon yoluyla PGM’lerin bünyesinde zenginleştirildiği demir matının çözeltiye alınma şartlarının belirlenmesi amacıyla hidroklorik asit varlığında farklı oksidanlar (ozon(O3) ve oksijen(O2)) kullanarak çözümlendirme şartları araştırılmıştır. En iyi deney şartlarının belirlenmesi için oksidan türü, oksidan miktarı, çözücü konsantrasyonu, karıştırma hızı ve reaksiyon sıcaklığı parametreleri incelenerek deneyler gerçekleştirilmiştir. %95 üzerinde verim; 5 gr örnek 4 M HCl 200 mL ile 50 mg O3/dakika ve 800 devir/dakika reaksiyon şartlarında 12 saat süre sonunda 60°C reaksiyon sıcaklığında elde edilebilmiştir. Deneylerin gerçekleştirildiği basamaklarda hammadde XRD analizi ile karakterize edilerek deneyde kullanılan hammaddenin yapısı aydınlatılmıştır. Çözünmeden geri kalan malzeme SEM-EDS yöntemi karakterize edilerek liç işlemi sonrası kalan yapı belirlenmiştir.
Comparison between endoscope assisted powered and conventional adenoidectomy
Authors: Sahni Dimple , Kaur Gurleen , Bhagat Sanjeev , Singh Parvinder , Verma Peeyush , Chhabra Nitin 
Published: December 2020

<p class="abstract"><strong>Background:</strong> Adenoidectomy is one of the commonest operations done on children. It is conventionally performed using the curettage method. This present study was done to compare the results of endoscopic powered adenoidectomy and conventional adenoidectomy.</p><p class="abstract"><strong>Methods:</strong> The present prospective randomized study was conducted among 50 patients between 4-16 years of age requiring adenoidectomy with or without tonsillectomy in department of ENT in Government Medical College and Rajindra Hospital, Patiala. All the 50 patients were divided into two groups (group A and group B) by systematic random sampling. Group A consisted of 25 patients who underwent conventional curettage adenoidectomy and group B consisted of 25 patients who underwent Microdebrider-Assisted Adenoidectomy. </p><p class="abstract"><strong>Results:</strong> In group A and B, mean±SD intraoperative blood loss (in ml) was 20.60±7.96 and 30.60±7.96 respectively. Mean±SD operative time (in minutes) was 28.60±4.71 in group A, while in group B it was 39.60±4.71 with statistically significant difference. Complete adenoid removal was found in 52% of the subjects in group A while it was found in 96% of the subjects in group B with statistically significant difference. In group A, mean±SD recovery time (in hrs) observed was 33.52±10.58 while in group B, recovery time (in hours) observed was 36.22±11.31.</p><p class="abstract"><strong>Conclusions:</strong> Based on the results of this study, it can be concluded that the new method of microdebrider assisted powered adenoidectomy was found to be safer and more useful tool for adenoidectomy than conventional method.</p>
A rare case of bilateral buccal lesions reconstructed with bipaddle submental artery island flap and buccal fat pad flap along with review of literature
Authors: Arora Viresh , Kathuria Bhushan , Arora Madhuri 
Published: December 2020

<p class="abstract">Reconstruction of full-thickness buccal defect involving oral commissure which demanding, it requires restoring competency of commissure besides providing lining for two surfaces simultaneously. Such defects prerequisites a pedicled flap each for mucosal and cutaneous surfaces else a free flap with double-paddle skin is needed. We present a case of a 45-year-old gentleman with bilateral buccal mucosa lesions; left side proliferative squamous cell carcinoma (T4N0M0) infiltrating into the cheek and right-sided large verrucous lesion. Reconstruction of verrucous lesion defect was done with buccal fat pad flap following wide local excision, while the SCC lesion resulting defect was reconstructed with de-epithelized bipaddle submental artery island flap (SAIF). Postoperatively patient had an uneventful recovery. The bipaddled SAIF has emerged as innovative modification of the conventional submental flap for reconstruction of composite oro-facial wounds provides lining for both surfaces, requires a shorter operative time than a free flap and avoids donor site deformity associated with double paddled Pectoralis cutaneous flap. The complexity of bilateral buccal defects and utilization of bipaddled design for reconstruction warrants submission of this case with just two cases reported in the literature. </p>
Cranial Magnetic Resonance Imaging as a Screening Tool for Evaluation of Silent Brain Ischemia in Severe Coronary Artery Disease: A Clinical Based Study
Authors: KURTOĞLU ÖZÇAĞLAYAN Tuğba İlkem , ÖZKARAMANLI GÜR Demet , ÖZÇAĞLAYAN Ömer , TOPCU Birol , ÜNAL Aysun 
Published: December 2020

Aim: Silent brain ischemia (SBI), defined as ischemic changes and infarcts without neurologic signs, is an established marker of poor survival. Magnetic resonance imaging (MRI) is useful to define SBI and white matter hyperintensities that correspond to microangipathic ischemic disease. This study aimed to investigate the relationship among SBI, white matter lesions and the extent of coronary artery disease (CAD), and to determine possible predictors of SBI.
Material and Methods: A total 10640 patients who underwent coronary angiography were retrospectively screened to reveal 312 patients who had been evaluated with a subsequent cranial MRI within 6 months. CAD severity was established with Gensini score and MRIs were evaluated to determine presence of SBI and white matter hyperintensities scored by Fazekas. Finally, 58 patients with SBI and 254 without SBI consisted SBI and non-SBI groups.
Results: Patients with SBI were significantly older with higher prevalence of male gender than the non-SBI patients. Both Gensini and Fazekas scores were higher in SBI-group (p
Serum Uric Acid Level and Cardiovascular Disease Development Risk in Stage 3-5 Chronic Kidney Disease Patients
Authors: KARAKOSE Suleyman 
Published: December 2020

Aim: The patients with chronic kidney disease (CKD) have higher risk of cardiovascular disease (CVD) than the general population and this risk increases in advanced CKD stages. The data about the association between CVD and uric acid level in stage 3-5 CKD patients are limited in the literature. The aim of this study is to investigate whether uric acid levels are associated with cardiovascular events and mortality in the CKD patients.
Material and Methods: Patients who were followed up with the diagnosis of stage 3-5 CKD between June 2014 and December 2019 were evaluated retrospectively. A hundred stage 3-5 CKD cases above the age of eighteen were included in the study. The patients were divided into two groups according to average serum uric acid levels;
relationship between negative affect, stress and body image in adolescent girls
Authors: Urvelyte Egle , Perminas Aidas 
Published: December 2020

Abstract
In recent decades, concerns about body image and dissatisfaction with it, especially significant increase in adolescents (Mousa, Mashal, Al-Domi HA, Jibril MA, 2010). According to studies, concerns about body image dissatisfaction has become a global phenomenon (Swami, Smith, 2012).
The aim of the study was to determine differences of body image satisfaction in adolescent girls with regard to stress and negative affect. The respondents were 80 adolescents from Kaunas city, who were enrolled in grades 8 and 10 (mean age =15.57 years;). Respondents completed the The Multidimensional Body-Self Relations Questionnaire (MBSRQ), PANAS-X Negative Affect scale and Reeder Stress inventory.
The results of this study showed that participants with higher stress were more dissatisfied with their body areas and less satisfied with their appearance compared to those who reported feeling less stressed. Girls with higher negative affect were more dissatisfied with their body areas, tended to invest less in their appearance, they also thought they weight is bigger, furthermore were more concerned with their weight and in general were less satisfied with their appearance.
The result of the present study demonstrate that as well as examining negative affect, it is also important to investigate other emotional components, which could be related to body image dissatisfaction, such as perceived stress.
Optimization of religious extension role in COVID-19 pandemic
Authors: Bastomi Hasan 
Published: December 2020

<p class="AbstrakAGC"><strong>Purpose - </strong> This study aims to investigate the optimization of the role of religious instructors in the midst of the COVID-19 pandemic.</p><p class="AbstrakAGC"><strong>Method -</strong> This research is a type of library research, namely, by recording all findings and integrating all findings, both theories and new findings about the religious extension, analyzing all findings from various reading and providing critical ideas about optimizing the role of religious instructors in the midst of the COVID-19 pandemic.</p><p class="AbstrakAGC"><strong>Result</strong> - The results of the study show that various issues in all sectors emerged as a result of the outbreak of the COVID-19 pandemic, it is necessary to optimize the role of religious instructors who play a very strategic role in the framework of mental, moral, and value development devotion of the people and also contribute to improving the quality of life of the people in various fields both in the field of religion and development amid COVID-19 pandemic by carrying out informative and educative functions, consultative functions, and advocacy functions.</p><p class="AbstrakAGC"><strong>Implications -</strong> To optimize the role, several things need to be done by religious instructors.</p><p><strong>Originality - </strong>The framework of mental development with optimization of religious extension role in the midst of COVID-19 pandemic.</p>
Formação continuada e prática profissional
Authors: Pereira dos Santos Andrea , Andrade Batista Cavalcanti Larissa 
Published: December 2020

Professores e bibliotecários são agentes formadores de indivíduos letrados em informação no contexto escolar e como tal carecem de formação continuada para a ampliação das suas práticas pedagógicas. Nesse sentido, a Universidade Federal de Goiás oferta o curso de Especialização em Letramento Informacional: educação para informação a fim de minimizar a lacuna na formação desses profissionais. O propósito desta pesquisa consistiu em identificar a ampliação do conceito de letramento informacional bem como ampliação e melhoria das práticas pedagógicas e/ou profissionais dos participantes do curso. Justificou-se por buscar compreender como os diferentes tipos de profissionais aplicam o letramento nas suas práticas profissionais após a conclusão do curso. Apresenta fundamentação teórica em letramento informacional por meio da releitura de autores como Gasque e Campello, que se dedicam à pesquisa nessa área do conhecimento. Para tanto, a pesquisa foi realizada a partir de análise documental sobre o curso e aplicação de questionário aos alunos concluintes. Desse modo, os resultados indicam que houve ampliação nas práticas pedagógicas da grande maioria dos participantes, principalmente no que se refere a práticas de pesquisa. O que permite concluir que o curso é uma proposta promissora para a formação de profissionais, principalmente na área da educação, com competências informacionais que os tornam capazes de formar indivíduos letrados.
KAJIAN YURIDIS TERHADAP PERATURAN HUKUM DALAM ASPEK TRANSPARANSI TERHADAP RISIKO PADA LAYANAN PRIORITY BANKING
Authors: Harsanto Renny Utaminingsih 
Published: December 2020

One of the new and innovative products offered in context of priority banking services is investment products. This research shall have a look at the transparency aspect of the risk management of this particular bank product offered to priority customers and will be conducted by a juridical normative method. In addition, the author also interviewed a number of key informants working in the banking industry at Bandung. The legal analysis conducted shows that while quite a number of rules and regulation in regard to risk management of bank investment products exist and are put in place, what it lacks, in terms of customer protection, is transparency.