bluuebunny/crossref_metadata_2025_split huggingface dataset:
miR-96-5p enhances cell proliferation and invasion via targeted regulation of ZDHHC5 in gastric cancer
Authors: Wang Baolong , Liu Xianrong , Meng Xiangtao 
Published: March 2020

AbstractObjective: To explore the biological function and mechanism of miR-96-5p in gastric cancer.Methods: The expression of differently expressed microRNAs (DEMs) related to gastric adenocarcinoma (GAC) prognosis was identified in GAC tumor samples and adjacent normal samples by qRT-PCR. A target gene miR-96-5p was selected using TargetScan, miRTarBase, miRDB databases. The combination of miR-96-5p and ZDHHC5 was verified by luciferase receptor assay. To further study the function and mechanism of miR-96-5p, we treated MGC-803 cells with miR-96-5p inhibitor and si-ZDHHC5, then detected cell viability, apoptosis, migration and invasion ability, as well as the expression of ZDHHC5, Bcl-2, Bax, cleaved caspase-3, cleaved caspase-9, and COX-2 by Western blot.Results: Compared with adjacent normal samples, the levels of miR-96-5p, miR-222-5p, and miR-652-5p were remarkably increased, while miR-125-5p, miR-145-3p, and miR-379-3p were significantly reduced in GAC tumor samples (P&lt;0.01), which were consistent with bioinformatics analysis. Furthermore, ZDHHC5 was defined as a direct target gene of miR-96-5p. miR-96-5p silence significantly reduced cell viability, increased cell apoptosis, and suppressed cell migration and invasion, as well as inhibited the expression of Bcl-2 and COX-2 and promoted Bax, cleaved caspase-3 and cleaved caspase-9 level in MGC-803 cells (P&lt;0.01). Notably, ZDHHC5 silence reversed the inhibiting effects of miR-96-5p on MGC-803 cells growth and metastasisConclusion: Our findings identified six microRNAs (miRNAs; miR-96-5p, miR-222-5p, miR-652-5p, miR-125-5p, miR-145-3p, and miR-379-3p) related to GAC prognosis, and suggested that down-regulated miR-96-5p might inhibit tumor cell growth and metastasis via increasing ZDHHC5 expression enhance MGC-803 cell apoptosis, as well as decrease MGC-803 cell metastasis.
Sleep Supports Memory and Learning: Implications for Clinical Practice in Speech-Language Pathology
Authors: Morrow Emily L. , Duff Melissa C. 
Published: March 2020

Purpose
This tutorial aims to draw attention to the interactions among memory, sleep, and therapy potential and to increase awareness and knowledge in the field of speech-language pathology of the potential impact of sleep as a mediating or moderating factor in promoting therapeutic outcome.

Method
We highlight key findings from the literature on the cognitive neuroscience of memory, the neurophysiology of sleep, how sleep supports memory, and how sleep disruption affects memory and learning abilities in populations commonly served in speech-language pathology.

Results
Research increasingly points to the critical importance of sleep quality and quantity to memory and learning, and sleep disruption is linked to deficits in functional cognition that may limit our clients' ability to benefit from speech pathology interventions.

Conclusions
As a field dedicated to promoting memory, learning, and relearning through our interventions, any systemic factors that affect these abilities demand our attention. Although speech-language pathologists do not treat sleep disturbance, we play a critical role in recognizing the signs and symptoms of sleep disturbance and making appropriate referrals, as undiagnosed and untreated sleep disturbance can have serious impacts on success in therapeutic contexts. By considering how related factors affect memory and learning, we have the opportunity to take a whole client approach to maximizing our clients' therapy potential and functional progress.
“Did I Say
Cherry
?” Error Patterns on a Blocked Cyclic Naming Task for Bilingual Children With and Without Developmental Language Disorder
Authors: McMillen Stephanie , Griffin Zenzi M. , Peña Elizabeth D. , Bedore Lisa M. , Oppenheim Gary M. 
Published: March 2020

Purpose
Using a blocked cyclic picture-naming task, we compared accuracy and error patterns across languages for Spanish–English bilingual children with and without developmental language disorder (DLD).

Method
Pictured stimuli were manipulated for semantic similarity across two (Same and Mixed) category contexts. Children's productions were scored off-line for accuracy, error frequency, and error type.

Results
Typically developing children were more accurate and produced fewer errors than their peers with DLD; however, this was moderated by task language and semantic context. Children were generally more accurate when naming pictures in English compared to Spanish and in the Mixed-category context compared to the Same-category context. Analyses of error types further showed that children with less English language exposure specifically produced more nonresponses in English than in Spanish. Children with DLD produced more of each error type than their typically developing peers, particularly in Spanish.

Conclusions
Regardless of language ability, bilingual children demonstrated greater difficulty with lexical retrieval for pictured items in the semantically related context than in the unrelated context. However, bilingual children with DLD produced more errors of all types than is typical for children developing more than one language. Their greater error rates are not secondary to limited second language exposure but instead reflect deficits inherent to the nature of language impairment. Results from this study are discussed using a framework of semantic constraint, where we propose that because bilingual children with DLD have impoverished semantic networks, and this knowledge insufficiently constrains activation for lexical selection, thereby increasing error production.
Tidal tails of open star clusters as probes to early gas expulsion
Authors: Dinnbier František , Kroupa Pavel 
Published: March 2020

Aims.We study the formation and evolution of the tidal tail released from a young star Pleiades-like cluster, due to expulsion of primordial gas in a realistic gravitational field of the Galaxy. The tidal tails (as well as clusters) are integrated from their embedded phase for 300 Myr. We vary star formation efficiencies (SFEs) from 33% to 100% and the timescales of gas expulsion as free parameters, and provide predictions for the morphology and kinematics of the evolved tail for each of the models. The resulting tail properties are intended for comparison with anticipatedGaiaobservations in order to constrain the poorly understood early conditions during the gas phase and gas expulsion.Methods.The simulations are performed with the codeNBODY6 including a realistic external gravitational potential of the Galaxy, and an analytical approximation for the natal gaseous potential.Results.Assuming that the Pleiades formed with rapid gas expulsion and an SFE of ≈30%, the current Pleiades are surrounded by a rich tail extending from ≈150 to ≈350 pc from the cluster and containing 0.7× to 2.7× the number of stars in the present-day cluster. If the Pleiades formed with an SFE close to 100%, then the tail is shorter (≲90 pc) and substantially poorer with only ≈0.02× the number of present-day cluster stars. If the Pleiades formed with an SFE of ≈30%, but the gas expulsion was adiabatic, the tail signatures are indistinguishable from the case of the model with 100% SFE. The mass function of the tail stars is close to that of the canonical mass function for the clusters including primordial gas, but it is slightly depleted of stars more massive than ≈1 M⊙for the cluster with 100% SFE, a difference that is not likely to be observed. The model takes into account the estimated contamination due to the field stars and the Hyades-Pleiades stream, which constitutes a more limiting factor than the accuracy of theGaiameasurements.
Lithium-rotation connection in the newly discovered young stellar stream Psc–Eri (Meingast 1)
Authors: Arancibia-Silva J. , Bouvier J. , Bayo A. , Galli P. A. B. , Brandner W. , Bouy H. , Barrado D. 
Published: March 2020

Context. As a fragile element, lithium is a sensitive probe of physical processes occurring in stellar interiors.
Aims. We aim to investigate the relationship between lithium abundance and rotation rate in low-mass members of the newly discovered 125 Myr-old Psc–Eri stellar stream.
Methods. We obtained high-resolution optical spectra and measured the equivalent width of the 607.8 nm LiI line for 40 members of the Psc–Eri stream, whose rotational periods have been previously derived.
Results. We show that a tight correlation exists between the lithium content and rotation rate among the late-G to early-K-type stars of the Psc–Eri stream. Fast rotators are systematically Li rich, while slow rotators are Li depleted. This trend mimics that previously reported for the similar age Pleiades cluster.
Conclusions. The lithium-rotation connection thus seems to be universal over a restricted effective temperature range for low-mass stars at or close to the zero-age main sequence, and does not depend on environmental conditions.
Endoscopic submucosal dissection (ESD) for Barrett’s esophagus (BE)-related early neoplasia after standard endoscopic management is feasible and safe
Authors: Tomizawa Yutaka , Friedland Shai , Hwang Joo Ha 
Published: March 2020

Abstract
Background and study aims There is little data on the feasibility and safety of endoscopic submucosal dissection (ESD) as a salvage treatment for Barrett’s esophagus (BE)-related neoplasia after standard endoscopic treatments.
Patients and methods A multicenter retrospective analysis on patients who underwent ESD for BE was performed. The primary endpoint was effectiveness of obtaining en-bloc resection in salvage as compared to non-salvage treatments.
Results Median age was 71 (IQR 55 – 79) years. Twelve (37%) of 32 patients underwent salvage ESD. Median resection time was 100 (IQR 60 – 136) minutes. En-bloc resection was achieved in 31 patients (97 %). Complete R0 resection was obtained in 75 % in the salvage group and 80 % in the non-salvage group (P = 1.00). In seven patients (22 %), the pre-ESD diagnosis was upgraded on post-ESD histopathology (1 low-grade dysplasia to high grade dysplasia [HGD], 4 HGD to early esophageal carcinoma (EAC), and 2 intramucosal EAC to invasive EAC). No perforations occurred in either group. Two late adverse events occurred, both in the salvage group (P = 0.133). Delayed bleeding occurred in a patient who had just resumed warfarin and stricture occurred in a patient who had a circumferential resection requiring serial dilation and stent placement.
Conclusions Our cohort study demonstrated that ESD as salvage therapy for BE related neoplasia is feasible and safe, achieving similar high rates of en-bloc resection and complete R0 resection as in treatment-naïve patients. Referral to an expert center performing ESD should be considered for patients with recurrence or progression following endoscopic mucosal resection or ablation therapy.
Cuffitis: is an endoscopic approach possible?
Authors: Serrero Mélanie , Santoni Aurélia , Grimaud Jean-Charles , Desjeux Ariadne , Gonzalez Jean-Michel , Barthet Marc 
Published: March 2020

Abstract
Background Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the reference surgical treatment for patients with ulcerative colitis (UC) refractory to medical treatment. One of the complications is leaving a strip of rectal mucosa which can be a cause of persistent inflammation or cuffitis. The objective of our study is to present an endoscopic approach for the treatment of cuffitis.
Methods This retrospective study included three patients who suffered from cuffitis after a proctocolectomy with IPAA for UC refractory to medical treatment. An endoscopic resection of the cuffitis was performed by the same operator. Two different techniques were used: hybrid endoscopic submucosal dissection (ESD) for one patient and mucosectomy with cap and resection for the two others.
Results The endoscopic treatment was performed successfully in all three patients. The only complication observed was rectal bleeding which did not require endoscopic revision. The three patients are now asymptomatic.
Conclusion Endoscopic treatment of cuffitis appears to be an interesting approach with few complications in the short term and good clinical efficacy.
Magnification endoscopy in combination with acetic acid enhancement and narrow-band imaging for the accurate diagnosis of colonic neoplasms
Authors: Shibagaki Kotaro , Ishimura Norihisa , Yuki Takafumi , Taniguchi Hideaki , Aimi Masahito , Kobayashi Keita , Kotani Satoshi , Yazaki Tomotaka , Yamashita Noritsugu , Tamagawa Yuji , Mishiro Tsuyoshi , Ishihara Shunji , Yasuda Akira , Kinshita Yoshikazu 
Published: March 2020

Abstract
Background and study aims Magnification endoscopy with narrow-band imaging (NBIME) and NBIME with acetic acid enhancement (A-NBIME) enable visualization of the vascular and microstructural patterns of colorectal polyp. We compared the diagnostic accuracy and reproducibility of white light endoscopy (WLE), NBIME, and A-NBIME for predictive histologic diagnosis.
Patients and methods Consecutive colorectal polyps (N = 628; 38 hyperplasias, 488 adenomas, 72 M-SM1 cancers, and 30 SM2 cancers) were photographed with WLE, NBIME, and A-NBIME. Endoscopic images were independently reviewed by three experts, according to the traditional criteria for WLE, the Japan NBI Expert Team classification for NBIME, and pit pattern classification for A-NBIME to compare diagnostic accuracy and interobserver diagnostic agreement among modalities.
Results The specificity (95 % confidence interval) of hyperplasia and SM2 cancer with WLE were 98.2 % (96.8 %–99.1%) and 99.4 % (98.5 %–99.9 %), respectively, showing high accuracy for endoscopic resection without magnifying observation. Diagnostic accuracy of WLE, NBIME, and A-NBIME was 80.8 % (77.4 %–83.8 %), 79.3 % (75.9 %–82.4 %), and 86.1 % (83.2 %–88.7 %), respectively, showing the highest accuracy for A-NBIME among modalities (P < .05). NBIME showed a lower PPV for M-SM1 cancer (P < .05), as with WLE (P = .08) compared to A-NBIME. Fleiss’s kappa values for WLE, NBIME, and A-NBIME diagnosis were 0.43 (0.39 – 0.46), 0.52 (0.49 – 0.56) and 0.65 (0.62 – 0.69), respectively, showing insufficient reproducibility of WLE and superiority of A-NBIME among modalities.
Conclusion WLE showed high accuracy for endoscopic resection of colorectal polyps in expert diagnosis. NBIME demonstrated a higher diagnostic reproducibility than WLE. A-NBIME showed possible superiority among modalities in both diagnostic accuracy and reproducibility.
Endoscopic sphincterotomy to prevent post-ERCP pancreatitis in patients with biliary neoplasms: a multicenter retrospective cohort study
Authors: Tamura Takashi , Ogura Takeshi , Takenaka Mamoru , Tanioka Kensuke , Itonaga Masahiro , Yamao Kentaro , Kamata Ken , Hirono Seiko , Okada Ken-ichi , Imanishi Miyuki , Higuchi Kazuhide , Yamaue Hiroki , Kitano Masayuki 
Published: March 2020

Abstract
Background and aims Treatment of biliary neoplasms often involves multiple endoscopic retrograde cholangiopancreatography (ERCP)-related procedures. Endoscopic sphincterotomy (ES) may prevent post-ERCP pancreatitis (PEP). This retrospective, multicenter cohort study aimed to investigate the effectiveness of ES for prevention of PEP in patients with biliary neoplasm.
Methods Patients with biliary duct neoplasm who underwent ERCP between January 2006 and December 2016 were enrolled. The frequency of PEP was compared between the ES and non-ES groups using propensity score analysis. The effectiveness of ES in subgroups of patients who underwent biliary duct stent placement, intraductal ultrasound (IDUS), and transpapillary biliary duct biopsy was analyzed by logistic regression.
Results Of the 362 patients enrolled, 84 (23.2 %) developed PEP. Propensity score matching for PEP risk factors in 172 ERCP procedures showed that the frequency of PEP in the ES group was lower than that in the non-ES group (19.7 % vs. 33.7 %). Non-ES was also an independent risk factor for PEP in patients who underwent intraductal ultrasound and transpapillary biliary duct biopsy (RR = 4.54 and 5.26), but was not an independent risk factor for PEP in patients with biliary duct stents. In addition, there was no evidence that the frequency of PEP was statistically different between patients with plastic stents and metal stents in the ES and non-ES groups (P = 0.14 and 0.10).
Conclusions ES is an effective technique to prevent PEP in patients with biliary neoplasms. In particular, ES is a safe technique to prevent PEP when performing IDUS and transpapillary biliary duct biopsy.
Methods and visualization tools for the analysis of medical, political and scientific concepts in Genealogies of Knowledge
Authors: Luz Saturnino , Sheehan Shane 
Published: March 2020

AbstractAn approach to establishing requirements and developing visualization tools for scholarly work is presented which involves, iteratively: reviewing published methodology, in situ observation of scholars at work, software prototyping, analysis of scholarly output produced with the support of text visualization software, and interviews with users. This approach is embodied by the software co-designed by researchers working on the Genealogies of Knowledge project. This paper describes our co-design methodology and the resulting software, presenting case studies demonstrating its use in test analyses, and discussing methodological implications in the context of the Genealogies of Knowledge corpus-based approach to the study of medical, scientific, and political concepts.
Diving into English motion verbs from a lexico-semantic approach
Authors: Durán-Muñoz Isabel , L’Homme Marie-Claude 
Published: March 2020

AbstractThis paper presents an analysis of English motion verbs in the specialized field of adventure tourism and proposes a terminological description of these verbs from a lexico-semantic approach. Motion verbs play a significant role in adventure tourism as they express central actions that are carried out in this domain and connect participants, such as tourists, places and typical instruments to these actions. The analysis aims to reveal how the linguistic properties of these verbs and their interactions with participants contribute to the expression of knowledge. After stating our assumptions and reviewing previous work, the article describes a corpus-based methodology to identify relevant verbs and the different steps taken to implement their description in theDicoAdventuredatabase. The methodology comprises three main steps and is illustrated by applying it to a set of motion verbs extracted from theAdvencorcorpus.
Morphosyntactic and semantic behaviour of legal phraseological units
Authors: Hourani-Martín Dunia , Tabares-Plasencia Encarnación 
Published: March 2020

Abstract
This paper analyses the morphosyntactic and semantic behaviour of a sample of verb-noun constructions (VNCs, Tabares Plasencia 2012) from the corpus CRIMO (Hourani Martín and Tabares Plasencia 2016), a specialised comparable corpus of different varieties of Spanish that
comprises the legislation on criminal law and criminal procedure from the Hispanic states. Our analysis revealed that topolectal
variation is common despite attempts by international organisations to harmonise the terminology used in this legal subdomain. It
will also be demonstrated that transformations of VNCs are pragmatically motivated and conditioned by the context. Examining these
transformations reveals conventions of specialised discourse and textual genre which is why their representation in
terminographical tools should be considered as they are an important means for a translator to achieve the adequacy and
naturalness required for legal translation.
Realization of the ITS-90 from 273.16 K to 692.677 K
Authors: Pokhodun A I , Rudtsch S , Ivanova A G , Beketov N A 
Published: March 2020

The bilateral comparison of the ITS-90 realizations at the National Metrological Institutes of Germany (PTB) and the Russian Federation (VNIIM) in the temperature range from 273,16 K to 692,677 K was initiated by the Technical Committee on "Thermometry and thermal physics" TC1.10 of COOMET.
The purpose of the comparison was to evaluate the differences between the realizations of the national standards in the most essential temperature range with the highest requirements to the measurement uncertainty. This temperature range includes five ITS-90 fixed points: the triple point of water, the melting point of gallium, the freezing points of indium, tin and zinc.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCT, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Symmetry-breaking and zero-one laws
Authors: Dowker Fay , Sorkin Rafael D 
Published: March 2020

Abstract
We offer further evidence that discreteness of the sort inherent in a causal set cannot, in and of itself, serve to break Poincaré invariance. In particular we prove that a Poisson sprinkling of Minkowski spacetime cannot endow spacetime with a distinguished spatial or temporal orientation, or with a distinguished lattice of spacetime points, or with a distinguished lattice of timelike directions (corresponding respectively to breakings of reflection-invariance, translation-invariance, and Lorentz invariance). Along the way we provide a proof from first principles of the zero-one law on which our new arguments are based.
Cross-diffusion on multiplex networks
Authors: Gao Shupeng , Chang Lili , Wang Xinyu , Liu Chen , Li Xuelong , Wang Zhen 
Published: March 2020

Abstract
During the past decades, pattern formulation with reaction–diffusion systems has attracted great research interest. Complex networks, from single-layer networks to more complicated multiplex networks, have made great contribution to the development of this area, especially with emergence of Turing patterns. While among vast majority of existing works on multiplex networks, they only take into account the simple case with ordinary diffusion, which is termed as self-diffusion. However, cross-diffusion, as a significant phenomenon, reveals the direction of species’ movement, and is widely found in chemical, biological and physical systems. Therefore, we study the pattern formulation on multiplex networks with the presence of both self-diffusion and cross-diffusion. Of particular interest, heterogeneous patterns with abundant characteristics are generated, which cannot arise in other systems. Through linear analysis, we theoretically derive the Turing instabilities region. Besides, our numerical experiments also generate diverse patterns, which verify the theoretical prediction in our work and show the impact of cross-diffusion on pattern formulation on multiplex networks.