bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived infection transmission routes, infection control practices, psychosocial changes, and management of COVID-19 infected healthcare workers in a tertiary acute care hospital in Wuhan: a cross-sectional survey
Authors: Jin Ying-Hui , Huang Qiao , Wang Yun-Yun , Zeng Xian-Tao , Luo Li-Sha , Pan Zhen-Yu , Yuan Yu-Feng , Chen Zhi-Min , Cheng Zhen-Shun , Huang Xing , Wang Na , Li Bing-Hui , Zi Hao , Zhao Ming-Juan , Ma Lin-Lu , Deng Tong , Wang Ying , Wang Xing-Huan 
Published: May 2020

Abstract
Background
Many healthcare workers were infected by coronavirus disease 2019 (COVID-19) early in the epidemic posing a big challenge for epidemic control. Hence, this study aims to explore perceived infection routes, influencing factors, psychosocial changes, and management procedures for COVID-19 infected healthcare workers.

Methods
This is a cross-sectional, single hospital-based study. We recruited all 105 confirmed COVID-19 healthcare workers in the Zhongnan Hospital of Wuhan University from February 15 to 29, 2020. All participants completed a validated questionnaire. Electronic consent was obtained from all participants. Perceived causes of infection, infection prevention, control knowledge and behaviour, psychological changes, symptoms and treatment were measured.

Results
Finally, 103 professional staff with COVID-19 finished the questionnaire and was included (response rate: 98.1%). Of them, 87 cases (84.5%) thought they were infected in working environment in hospital, one (1.0%) thought their infection was due to the laboratory environment, and 5 (4.9%) thought they were infected in daily life or community environment. Swab of throat collection and physical examination were the procedures perceived as most likely causing their infection by nurses and doctors respectively. Forty-three (41.8%) thought their infection was related to protective equipment, utilization of common equipment (masks and gloves). The top three first symptoms displayed before diagnosis were fever (41.8%), lethargy (33.0%) and muscle aches (30.1%). After diagnosis, 88.3% staff experienced psychological stress or emotional changes during their isolation period, only 11.7% had almost no emotional changes. Arbidol (Umifenovir; an anti-influza drug; 69.2%) was the drug most commonly used to target infection in mild and moderate symptoms.

Conclusion
The main perceived mode of transmission was not maintaining protection when working at a close distance and having intimate contact with infected cases. Positive psychological intervention is necessary.
Mucosa-associated lymphoid tissue (MALT) lymphoma developing in ectopic mediastinal thyroid tissue: a case report
Authors: Uchida Naotaka , Yoshida Manabu 
Published: May 2020

Abstract
Background
Normally located in the neck, ectopic mediastinal thyroid tissue consists of very rare ectopic thyroid tissue that does not connect to the thyroid gland. A patient with mucosa-associated lymphoid tissue (MALT) lymphoma that has developed in mediastinal thyroid tissue, to our best knowledge, has not been previously reported.

Case presentation
A 67-year-old woman presented with a superior mediastinal mass that was revealed by chest computed tomography (CT), an optional examination she hoped, during a medical checkup. Contrast-enhanced CT scan performed in our hospital for close examination confirmed the presence of a 2 × 1.3 cm poorly enhanced mass anterior to the trachea during the arterial phase. Magnetic resonance imaging depicted low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. I-131 meta-iodobenzylguanidine did not accumulate in the mass. Serum levels of interleukin-2 receptor, catecholamine, and anti-acetylcholine receptor antibody were within the normal range. The mass was resected through a transverse neck incision for the diagnosis and treatment. The histopathological diagnosis of the specimen was ectopic mediastinal thyroid tissue associated with MALT lymphoma and chronic thyroiditis. Immunoglobulin heavy chain class switch recombination was identified. Fine-needle aspiration biopsy of the cervical thyroid showed chronic thyroiditis but not lymphoma. The patient’s postoperative thyroid function was normal. To date, the patient’s recovery has been uneventful, and she is being monitored without further treatment.

Conclusion
We treated the patient with MALT lymphoma that developed in ectopic mediastinal thyroid tissue. This novel case illustrates a new differential diagnosis associated with ectopic mediastinal thyroid tissue.
A study protocol to assess the feasibility of conducting an evaluation trial of the ADVANCE integrated intervention to address both substance use and intimate partner abuse perpetration to men in substance use treatment
Authors: Gilchrist Gail , Landau Sabine , Radcliffe Polly , McMurran Mary , Feder Gene , Easton Caroline , Parrott Steve , Kirkpatrick Sara , Henderson Juliet , Potts Laura , Stephens-Lewis Danielle , Johnson Amy , Love Beverly , Halliwell Gemma , Dheensa Sandi , Berbary Cassandra , Li Jinshuo , Strang John , Gilchrist Elizabeth 
Published: May 2020

AbstractBackgroundStrong evidence exists that substance use is a contributory risk factor for intimate partner abuse (IPA) perpetration. Men in substance use treatment are more likely to perpetrate IPA than men from the general population. Despite this, referral pathways are lacking for this group. This trial will assess the feasibility of conducting an evaluation trial of a tailored integrated intervention to address substance use and IPA perpetration to men in substance use treatment.Methods/designADVANCE is a multicentre, parallel-group individually randomised controlled feasibility trial, with a nested formative evaluation, comparing an integrated intervention to reduce IPA + substance use treatment as usual (TAU) to TAU only. One hundred and eight men who have perpetrated IPA in the past 12 months from community substance use treatment in London, the West Midlands, and the South West will be recruited. ADVANCE is a manualised intervention comprising 2–4 individual sessions (2 compulsory) with a keyworker to set goals, develop a personal safety plan and increase motivation and readiness, followed by a 12-session weekly group intervention delivered in substance use services. Men will be randomly allocated (ratio 1:1) to receive the ADVANCE intervention + TAU or TAU only. Men’s female (ex) partners will be invited to provide outcome data and offered support from integrated safety services (ISS). Regular case management meetings between substance use and ISS will manage risk. Outcome measures will be obtained at the end of the intervention (approximately 4 months post-randomisation) for all male and female participants. The main objective of this feasibility trial is to estimate parameters required for planning a definitive trial including rates of consent, recruitment, and follow-up by site and group allocation. Nested formative evaluation including focus groups and in-depth interviews will explore the intervention’s acceptability to participants, group facilitators, keyworkers and ISS workers. Secondary outcomes include substance use, IPA, mental health, self-management, health and social care service use, criminal justice contacts, and quality of life.DiscussionFindings from this feasibility trial will inform the design of a multicentre randomised controlled trial evaluating the efficacy and cost-effectiveness of the ADVANCE intervention for reducing IPA and improving the well-being of female (ex)partners.Trial registrationISRCTN79435190.
Landiolol hydrochloride for prevention of atrial fibrillation during esophagectomy: a randomized controlled trial
Authors: Aoki Yoshitaka , Kawasaki Yohei , Ide Kazuki , Shimizu Yuichiro , Sato Shinsuke , Yokoyama Junichiro 
Published: May 2020

Abstract
Introduction
Landiolol hydrochloride reduces the incidence of perioperative atrial fibrillation (AF) in cardiac surgery; however, little evidence is available regarding its effects in other types of surgery, including esophagectomy. We assessed the hypothesis that landiolol reduces perioperative AF and other complications associated with esophagectomy.

Methods
This single-center, randomized, double-blind, parallel-group study enrolled patients scheduled for esophagectomy. Patients were divided into those given landiolol at 3 μg/kg/min or placebo for 24 h. The primary outcome was the proportion of patients who developed AF within 96 h starting at 9:00 am on the day of surgery. The secondary outcomes were the proportion of patients whose AF appeared within 24 h, other complications based on the Clavien–Dindo classification, and the intensive care unit and hospital stays.

Results
Despite early study termination, 80 patients were screened, and 56 were enrolled (28/group) from September 2016 to June 2018. AF occurred within 96 h of surgery in six (21.4%) patients in the landiolol group and five (17.9%) patients in the placebo group (odds ratio, 1.26; 95% confidence interval, 0.33–4.7) and within 24 h of surgery in three (10.7%) patients in the landiolol group and two (7.1%) patients in the placebo group. There were no significant differences in the incidence of complications or in the number of intensive care unit or hospital stays between the groups.

Conclusion
Although our small sample size prevents definitive conclusions, landiolol might not reduce the occurrence of AF or other complications.

Trial registration
UMIN, UMIN000024040. Registered 13 September 2016, http://www.umin.ac.jp/ctr/index/htm
Evaluation of 511 keV photon attenuation by a novel 32-channel phased array prospectively designed for cardiovascular hybrid PET/MRI imaging
Authors: Farag Adam , Thompson R. Terry , Thiessen Jonathan D. , Biernaski Heather , Prato Frank S. , Théberge Jean 
Published: May 2020

Abstract
Background
Simultaneous cardiovascular imaging with positron emission tomography (PET) and magnetic resonance imaging (MRI) requires tools such as radio frequency (RF) phased arrays to achieve high temporal and spatial resolution in the MRI, as well as accurate quantification of PET. Today, high-density phased arrays (> 16 channels) used for cardiovascular PET/MRI are not designed to achieve low PET attenuation, and correcting the PET attenuation they cause requires off-line reconstruction, extra time and resources.

Purpose
Motivated by previous work assessing the MRI performance of a novel prospectively designed 32-channel phased array, this study assessed the PET image quality with this array in place. Guided by NEMA standards, PET performance was measured using global PET counts, regional background variation (BV), contrast recovery (CR) and contrast-to-noise ratio (CNR) for both the novel array and standard arrays (mMR 12-channel and MRI 32-channel). Nonattenuation-corrected (NAC) data from all arrays (and each part of the array) were processed and compared to no-array, and relative percentage difference (RPD) of the global means was estimated and reported for each part of the arrays. Attenuation correction (AC) of PET images (water in the phantom) using two approaches, MR-based AC map (MRAC) and dual-energy CT-based map (DCTAC), was performed, and RPD compared for each part of the arrays. Percent mean attenuation within regions of interests of the phantom images from each array were compared using a two-way analysis of variance (ANOVA).

Results
The NAC data of the anterior part of the novel array recorded the least PET attenuation (≤ 2%); while the full novel array (anterior and posterior together) AC data, produced by MRAC and DCTAC approaches, recorded attenuation of 1.5 ± 2.9% and 0.0 ± 2.5%, respectively. The novel array PET count loss was significantly lower (p = 0.001) than those caused by the standard arrays.

Conclusions
Results of this novel 32-channel cardiac array PET performance evaluation, together with its previously reported MRI performance assessment, suggest the novel array to be a strong alternative to the standard arrays currently used for cardiovascular hybrid PET/MRI imaging. It enables accurate PET quantification and high-temporal and spatial resolution for MR imaging.
Isolation and efficacy of native chitinolytic rhizobacteria for biocontrol activities against Fusarium wilt and plant growth promotion in pigeon pea (Cajanus cajan L.)
Authors: Dukare Ajinath , Paul Sangeeta , Arambam Asha 
Published: May 2020

AbstractThe present study aimed to identify, characterize, and evaluate native chitinolytic rhizobacteria as biocontrol potential against pigeon pea wilt disease, caused by Fusarium udum. A total of 53 isolated rhizobacteria was evaluated for their chitinolytic potential and possession of different antifungal traits. From the successive in vitro experiments and in vivo bioassay, 2 promising bacterial strains (NS-1 and NS-22) that exhibited strong chitinolytic activities and mycolytic action were biochemically characterized and identified as Pseudomonas spp. NS-1 (NCBI GenBank accession number- KT175909) and Bacillus spp. NS-22 (NCBI GenBank accession number-MH425454), using 16S rDNA sequencing. In planta, disease severities for Pseudomonas spp. NS-1- and Bacillus spp. NS-22-treated plants were only about 14.62 and 23.08%, respectively, as compared to pathogen-only control (67.34%) at the end of 4 weeks. Additionally, these bacteria improved plant germination and fresh and dry plant biomasses under pathogen-challenged conditions. Further, both the strains were able to cause a considerable amount of reduction in the fungal biomass, as revealed by bacteria-pathogen interaction studies in liquid culture. Scanning electron microscopy studies also revealed the strong antifungal activities of these 2 chitinolytic bacteria on the pathogen hyphae and mycelia. The curling, bulging, breakdown, and other dysfunctionalities in fungal hyphae were induced by the biocontrol bacteria. In nutshell, the present exclusive investigation demonstrated mycolytic potential and biocontrol prospects of the 2 promising bacteria (Pseudomonas spp. NS-1 and Bacillus spp. NS-22) for the sustainable Fusarium wilt management and as a phytostimulator in pigeon pea.
Microendoscopic anterior cervical foraminotomy: a preliminary series of 76 cases
Authors: Kabil Mohamed Samir , Abdel-ghany Walid 
Published: May 2020

AbstractBackgroundAnterior cervical foraminotomy represents a relatively recent minimally invasive approach that can potentially preserve the intervertebral disc and thus the functional motion segment.ObjectiveThis study aims to evaluate the clinical outcome of microendoscopic anterior cervical foraminotomy (MACF) for patients with cervical unilateral radiculopathy due to single level soft disc herniation or hard disc-osteophyte complex (DOC).MethodsIn the period between August 2009 and March 2015, 76 consecutive patients with symptomatic unilateral cervical radiculopathy were included in this study. There were 40 left-sided cervical radiculopathy cases and 36 right-sided; of those, 42 had soft disc fragment herniation, 18 had DOC, 12 had a migrated disc fragment whether cranial or caudal, and four had far lateral (foraminal) disc herniation. In all cases, MACF with root decompression was performed. Cervical magnetic resonance imaging (MRI), computed tomography (CT) scan, and plain X-rays were performed for all patients and then repeated postoperatively. All patients were followed-up for at least a year. Clinical and functional outcomes were assessed using visual analogue scale (VAS) and Odom’s criteria.ResultsAccording to VAS score, there was an improvement in neck pain from 6.4 (range 5–10) to 1.5 (1–5) and in arm pain from 7.2 (range 6–10) to 1.2 (0–4) at final follow-up (P< 0.05). Functional outcomes according to Odom’s criteria were excellent in 59 (78%) cases, good in ten (13%), fair in six (8%), and poor in one (1%) case. Success of surgery was considered to be achieved in 91% (excellent + good) of cases. Mean operating time was 81 min, and mean intraoperative blood loss was 21 ml. Most significant complications included a dural tear in one case, transient postoperative dysesthesia in six cases, excess bony work resulting in unintended uncinectomy in three cases, fracture of transverse process in one case, unintended near total discectomy in two cases, infective discitis in one case, and persistent radicular pain due to incomplete osteophyte removal in one case.ConclusionsThis preliminary report suggests that MACF yields overall excellent results in selected patients with unilateral cervical radiculopathy. The technique potentially can preserve the functional motion segment, thus patients typically experience immediate postoperative neck mobility and do not need to wear a cervical collar.
A pharmacological characterization of Cannabis sativa chemovar extracts
Authors: Devsi Alykhan , Kiyota Brett , Ouellette Theophile , Hegle Andrew P. , Rivera-Acevedo Ricardo E. , Wong Jasper , Dong Ying , Pugsley Michael K. , Fung Timothy 
Published: May 2020

Abstract
Background
Cannabis contains Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) as the primary constituents responsible for pharmacological activity. However, there are numerous additional chemically-related structures to Δ9–THC and CBD that are pharmacologically active and may influence the pharmacological properties of Δ9-THC and CBD. This study chemically characterized the cannabinoid constituents in a series of cannabis chemovar extracts and investigated the potential cannabinoid entourage effect in two behavioral assays.

Methods
Six chemovar extracts were compared to pure Δ9-THC, CBD and morphine for effects on the following behavioral assays in mice: hot plate and tail suspension. The battery of behavioral tests was conducted post intravenous administration of cannabis chemovar extract. Cannabinoid profiles of extracts were analyzed using high performance liquid chromatography. Cannabis extracts were administered at equal doses of Δ9-THC to investigate the role of their cannabinoid profiles in modulating the effects of Δ9-THC. Dose response curves were fit using a log[inhibitor] vs response three parameter model and differences between group means were determined using a one-way ANOVA followed by a post hoc test.

Results
Cannabis chemovars tested in this study exhibited substantially different cannabinoid profiles. All chemovars produced dose-dependent immobility in the tail suspension assay and dose-dependent antinociception in the hot plate assay. The maximum antinociceptive effect and ED50 was comparable between cannabis chemovars and Δ9-THC. Two cannabis chemovars produced significantly greater immobility in the tail suspension test, with no significant differences in ED50.

Conclusions
Commercially available cannabis chemovars vary widely in cannabinoid content, but when equalized for Δ9-THC content, they produce similar behavioral effects with two exceptions. These findings provide only limited support for the entourage hypothesis. Further studies are necessary to characterize the nature of these pharmacological differences between cannabis chemovars and pure Δ9-THC.
Impact of intermittent dietary restriction on the health-related outcomes of faith-based fasting
Authors: Halawa Abdelhadi 
Published: May 2020

Abstract
Background and purpose
For much of the history of studying the effects of intermittent fasting on the health of people who engage in fasting for religious reasons, there has been no conclusive evidence-based consensus on the health outcomes of this form of intervallic fasting. The purpose of the present study is to examine the health-related outcomes of intermittent faith-based fasting. Whereas there are several forms of faith-based and non-faith based fasting, the present study will be primarily dedicated to examining the health effects associated with one of the most ubiquitous forms of religious fasting practiced globally by the preponderance of the eligible adults among 1.8 billion Muslims, which is fasting during the annual Islamic month of Ramadan. Therefore, Ramadan fasting provides a significant research paradigm to investigate the health effects of intervallic fasting in humans.

Methods
A systematic review and meta-analysis methodology was employed to search major databases, printed books, and official web-based electronic publications to identify and select a multitude of relevant peer-reviewed studies on the health effects of faith-based intermittent fasting. The data garnered from the selected studies were systematically reviewed, analyzed, and combined. The findings were compared and examined to evaluate whether there were patterns of significant or no significant results of specific health-related effects associated with intermittent faith-based fasting.

Results
The systematic review and data analysis suggest that Ramadan intermittent fasting is associated with both health risks and health benefits. The most vulnerable group of people who are most at risk for exposure to adverse health effects of fasting are those individuals who fast Ramadan with underlying pre-existing health conditions such as diabetes, asthma, kidney, and cardiovascular diseases, which can be exacerbated by the daily fasting for long hours.

Conclusions
The health outcomes of intermittent fasting and voluntary caloric restriction are prefatory and inconclusive The findings of the present study suggest that there is scientific evidence to support the hypothesis that intermittent fasting and forms of meal timing schedules may be associated with both favorable and unfavorable health outcomes. Fasting individuals with adverse pre-exciting health conditions would benefit significantly from seeking a pre-Ramadan medical evaluation, personalized dietary counseling, and Ramadan fasting-tailored health and wellness education as imperative interventions to avert potential medical crises and reduce any further health complications.
Characteristics of different ethnic and traditional bread from the perspective of Islamic traditional medicine
Authors: Emami Seyed Ahmad , Sobhani Zahra 
Published: May 2020

Abstract
Background
Bread is one of the staple foods throughout the world due to its great nutritional attributes. There are numerous types of bread in different countries that some of them are specific to a particular region or ethnic group. Bread is one of the main sources of the daily dietary pattern of Iranian society and Muslims and it satisfies a large part of daily energy needs. Therefore, it has long been considered by Islamic traditional practitioners. In Islamic traditional medicine (ITM), the first step in treatment is the modification of the diet based on a person’s temperament and humors. For this reason, special attention has been paid to bread as a staple food.

Scope and approach
This review described the ethnic bread of Iran and the views of some prominent ITM scientists such as Ibn Beytâr, Ibn Sinâ, Râzi, and Aqili on bread. They described the characteristics of the different types of bread based on the flour used, the amount of bran, and the method of baking with details. Furthermore, they prescribe a specific bread according to the nutritional value of each bread, the speed of digestion, and the temperament of the individual.

Key findings and conclusions
Following the recommendations of traditional medicine can improve the bakery industry as well as reduce the side effects of some bread and their related diseases.