bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyhedral Oligomeric Silsesquioxane /Platelets Rich Plasma/Gelrite-Based Hydrogel Scaffold for Bone Tissue Engineering
Authors: Ahmadipour Saeedeh , Varshosaz Jaleh , Hashemibeni Batool , Safaeian Leila , Manshaei Maziar 
Published: March 2020

Background:
Polyhedral oligomeric silsesquioxane (POSS) is a monomer with silicon structure and an
internal nanometric cage.

Objective:
The purpose of this study was to provide an injectable hydrogel that could be easily located in open or
closed bone fractures and injuries, and also to reduce the possible risks of infections caused by bone graft either
as an allograft or an autograft.

Methods:
Various formulations of temperature sensitive hydrogels containing hydroxyapatite, Gelrite, POSS and
platelets rich plasma (PRP), such as the co-gelling agent and cell growth enhancer, were prepared. The hydrogels
were characterized for their injectability, gelation time, phase transition temperature and viscosity. Other physical
properties of the optimized formulation including compressive stress, compressive strain and Young’s modulus as
mechanical properties, as well as storage and loss modulus, swelling ratio, biodegradation behavior and cell toxicity
as rheometrical parameters were studied on human osteoblast MG-63 cells. Alizarin red tests were conducted
to study the qualitative and quantitative osteogenic capability of the designed scaffold, and the cell adhesion to
the scaffold was visualized by scanning electron microscopy.

Results:
The results demonstrated that the hydrogel scaffold mechanical force and injectability were 3.34±0.44
Mpa and 12.57 N, respectively. Moreover, the scaffold showed higher calcium granules production in alizarin red
staining compared to the control group. The proliferation of the cells in G4.5H1P0.03PRP10 formulation was significantly
higher than in other formulations (p<0.05).

Conclusion:
The optimized Gelrite/Hydroxyapatite/POSS/PRP hydrogel scaffold has useful impacts on osteoblasts
activity, and may be beneficial for local drug delivery in complications including a break or bone loss.
A Peptide Construct Mediates Focal Adhesion Pathway Through the Activation of Integrin Receptor
Authors: Khosravi Mohsen , Kakavandi Naser , Rezaee Shima , Shabani Mohammad , Najafi Mohammad 
Published: March 2020

Background:
The integrin family receptors stimulate the cellular proliferation and migration through
the focal adhesion pathway by the activation of PTK2, VASP and TSP1 proteins. The purpose of this study was
to investigate the integrin-ligated motifs through the activation of focal adhesion pathway.

Methods:
A chimeric peptide was predicted from the integrin-mediated ligands by bioinformatics tools. The
VSMCs were treated with the chimeric peptide and simvastatin. The PTK2, VASP and TSP1 protein and gene
expression levels were measured by RT-qPCR and Western Blotting techniques, respectively. AutoDock Tools
were used for the docking technique.

Results:
The PTK2, VASP and TSP1 protein expression levels increased significantly in the VSMCs treated with
chimeric peptide in conversely with the effects of simvastatin. The docking results suggested two motifs in the
chimeric peptide.

Conclusion:
In conclusion, the chimeric peptide activated the focal adhesion pathway. The motifs 1 and 2 may be
directly involved in the transduction of signal by integrin family receptors.
Development of an Oral Amphotericin B Formulation as an Alternative Approach to Parenteral Amphotericin B Administration in the Treatment of Blood-Borne Fungal Infections
Authors: Wasan Kishor M. 
Published: March 2020

:
In the Fall of 1999, we presented at medical “Grand Rounds” to a number of Infectious Diseases physicians
at Vancouver General Hospital about the co-administration of several antifungal compounds in the treatment
of blood-borne fungal infections to patients who were immunocompromised (i.e. cancer patients, patients
waiting organ transplantation, HIV/AIDs patients, etc.). During the presentation, a physician from the back of the
room called out “can you develop an oral formulation of amphotericin B which could be effective and not have
the side-effects associated with the parenteral formulations of the drug”. The physician stated that an oral formulation
would be a big step forward, improving patient compliance, helping in pre-treatment without admitting
patients to the hospital prior to organ transplantation and it would be cost-effective.
Initially, I responded to the physician, that it would not be possible to develop an oral amphotericin B formulation
that could be absorbed from the gastrointestinal (GI) tract in a high enough concentration to be effective in treating
blood-borne fungal infections and yet remains non-toxic due to the physical chemical properties of the drug.
However, as I travelled back to my lab from the meeting, it struck me that our understanding of how lipids had
been processed and orally absorbed from the GI had advanced to the point the maybe incorporating amphotericin
B into such lipids might work.
Within several years, our laboratory was able to develop a novel oral amphotericin B formulation that was indeed
effective in treating systemic fungal infections without the side-effects associated with the drug in a variety of
fungal animal models.
Experiences and Needs of Multicultural Youth and Their Mentors, and Implications for Digital Mentoring Platforms: Qualitative Exploratory Study
Authors: Radlick Rebecca Lynn , Mirkovic Jelena , Przedpelska Sarah , Halvorsen Brendmo Elanor , Gammon Deede 
Published: March 2020

Background
Mentoring programs (ie, programs that connect youths with adult volunteers) have been shown to improve outcomes across the behavioral, social, and academic domains of youth development. As in other European countries, mentoring programs have few traditions in Norway, where interventions for multicultural youths are usually profession driven and publicly funded. Faced with the risk of disparities in education and health, there is a need to better understand this group’s experiences and requirements relative to mentoring. This would also serve as a basis for designing and implementing digital support.

Objective
The objective of this study was to gain insight into multicultural youth mentees’ and adult mentors’ experiences and needs in the context of an ongoing mentoring program, how digital support (electronic mentoring) might address these needs, and how such support could be designed and implemented.

Methods
The study used a qualitative approach, with data from 28 respondents (21 mentees and 7 mentors). In total, 4 workshops with mentees as well as semistructured interviews with mentees and mentors were conducted. The sessions were audio recorded, transcribed, and analyzed thematically.

Results
In total, 3 main themes were identified from the experiences and needs reported by the mentees and mentors. These included a need for connection, help in achieving goals, and the need for security and control. Subthemes encompassed a desire to socialize with others, balancing the nature of the relationship, paying it forward, building trust, sharing insights and information with peers, goal-oriented mentees and mentors wanting to assist with goal achievement, and the fundamental need for privacy and anonymity in the digital platform.

Conclusions
The findings of this study are supported by the literature on traditional mentoring, while also offering suggestions for the design of digital solutions to supplement the in-person mentoring of multicultural youth. Suggestions include digital support for managing the mentee-mentor relationships, fostering social capital, and ways of ensuring security and control. Features of existing electronic health apps can be readily adapted to a mentoring program context, potentially boosting the reach and benefits of mentoring.
Daily Self-Monitoring of Symptoms and Skills Learning in Patients With Borderline Personality Disorder Through a Mobile Phone App: Protocol for a Pragmatic Randomized Controlled Trial
Authors: Helweg-Jørgensen Stig , Beck Lichtenstein Mia , Fruzzetti Alan E , Møller Dahl Christian , Pedersen Susanne S 
Published: March 2020

Background
Patient self-monitoring via mobile phones during psychotherapy can enhance and provide an overview of psychotherapeutic progress by graphically displaying current and previous symptom scores, providing feedback to the patient, delivering psychoeducative material, and providing timely data to the therapist or treatment team.

Objective
This study will aim to assess the effects of using a mobile phone to self-monitor symptoms and acquire coping skills instead of using pen and paper during psychotherapy in patients with borderline personality disorder (BPD). Dialectical behavior therapy will be performed to treat BPD. The primary outcome is the mean time needed to learn coping skills directed at emotion regulation; the secondary outcome is changes in the BPD symptom score as measured by the Zanarini Rating Scale for Borderline Personality Disorder.

Methods
This study is a pragmatic, multicenter randomized controlled trial. Participants were recruited through five public general psychiatric outpatient treatment facilities in Denmark. Patients are randomly assigned, on a 1:1 basis, to either the mobile phone condition (using the Monsenso mDiary mobile app) or pen-and-paper condition. Patients will complete several self-report questionnaires on symptom severity; assessments by trained raters on BPD severity will be performed as well. Survival analysis with a shared frailty model will be used to assess the primary outcome.

Results
Recruitment began in June 2017 and was completed in February 2019 after 80 participants were recruited. The study ended in February 2020. It is expected that the benefits of mobile phone–based self-report compared to the pen-and-paper method will be demonstrated for skill learning speed and registration compliance. To our knowledge, this is the first trial exploring the impact of cloud-based mobile registration in BPD treatment.

Conclusions
This trial will report on the effectiveness of mobile phone–based self-monitoring during psychiatric treatment. It has the potential to contribute to evidence-based clinical practice since apps are already in use clinically.

Trial Registration
ClinicalTrials.gov NCT03191565; https://clinicaltrials.gov/ct2/show/NCT03191565

International Registered Report Identifier (IRRID)
DERR1-10.2196/17737
Growth performance of Wader Cakul juvenile (Puntius binotatus) with different stocking density
Authors: Prasetyo Dony , Zubaidah Anis , Noviana Vera 
Published: March 2020

One of the freshwater fishes thatbegan to bedeveloped is Wader fish, but there is still a lot of information that has notbeen supportedon fish farming techniques. One of them is the optimal stocking density for cultivation. The purpose of this study was to study the effects of different stocking densities on the growth and survival rates of the WaderCakulfish (Puntiusbinotatus).This research was conductedin May - July 2018. The method used in this study was to use aCompletely Randomized Design with 4 training, namely P1 (2 fish/liter), P2 (3 fish/liter), P3 (4 fish/liter) and P4 (5 fish/liter).Each treatment was repeated3 times. The main parameters were absolute growth rate (length and weight gain)(GR), specific growth rate (SGR), survival rate (SR), and feed conversion ratio (FCR).Data were analyzedusing ANOVA (analysis of variance) and continued with the Least Significant Difference Test. The results showed that different stocking densities gave significant values (P <0.05) for GR, SGR, SR and FCR comparisons. The best treatment in this study was P1 with a growth value of 0.31 ± 0.01 gram, SGR 3.50 ± 0.03%, Long Growth 1.97 ± 0.05 cm, SR 85.07 ± 2.17% and FCR 1.47 ± 0.02. P1 (2 fish/liter) is the best maintenance to increase the growth, survival rate, and feed efficiency of thecakulwader fish.
Effectiveness of strychnine bush extract (Strychnos ligustrina blume) against to prevalence and survival rate of Dumbo catfish (Clarias gariepinus) infected with Aeromonas hydrophila
Authors: Zubaidah Anis , Samsundari Sri , Hidayaturrahmi Hidayaturrahmi 
Published: March 2020

One of the problemsofintensive catfish culture is the attack of Motile Aeromonas Septicemia disease caused by Aeromonas hydrophila bacteria. To prevent it is necessary to prevent the use of natural antibiotics that is strychnine bush extract. The purpose of this research is to know the ability of strychnine bush extract (Strychnos ligustrina Blume) using methanol solvent in inhibiting the growth of Aeromonas hydrophila bacteria and its effect on prevalence and survival rate in Dumbo catfish (Clarias gariepinus). The method used in this research is the exsperimen method by using complete randomized design (RAL). In this study there were five treatments with different doses of treatment (P1: 6%), (P2: 12%), (P3: 18%), (P4: 24%) and (P5: 30%), each treatment was repeated three replications. Furthermore, the data were analyzed using ANAVA and continued with LSD test. The results showed that the giving of strychnine bush extract with different concentrations had a very significant effect on the width of the Aeromonas hydrophila bacterial resistance zone. The lowest inhibition of the treatment (P1: 6%) with a resistance of 1.79 mm. While the highest inhibition of treatment (P5: 30%) with 8.29 mm inhibition power. In prevalenceofdumbo catfish with givingofsongga extract very real effect, treatment with lowest prevalence is treatment (P4: 24%) with prevalence value 23,3% andhighestpervalence that is treatment (P5: 30%) with prevalence value equal to 40 %. In the synthesisofdumbo catfish with the giving of strychnine bush extract have a very real effect, the treatment with lowest stability is treatment (P4: 30%) with 77% syntax value and the highest synthesis of treatment (P5: 24%) with 90% syntax value. This study resulted in the conclusion that the best treatment for prevalence and survival rate is treatment (P4: 24%). As for the higher inhibition power dose strychnine bushextractis used then the higher the power inhibition.
Videojuego educativo como recurso para conocer y proteger animales en peligro de extinción
Authors: Ortiz Ricardo , Telles Yefferson , Ortiz José 
Published: March 2020

Se propone un videojuego educativo, como recurso de apoyo al aprendizaje de las Ciencias Naturales, del sexto grado de Educación Primaria. Se asume que el uso adecuado de tecnología en el aprendizaje contribuye a la comprensión y aplicación de los conceptos y propiedades vinculados con el medio ambiente. Como metodología se recurrió al proyecto factible. Para la elaboración de la propuesta se partió del diagnóstico de la situación resultado del trabajo de campo desarrollado en una Escuela Básica Nacional, del Estado Aragua (Venezuela). La información se obtuvo a través de una entrevista al docente de sexto grado de primaria y la aplicación de un cuestionario a los 22 alumnos cursantes del año escolar 2018-2019. La información recabada aportó una aproximación a la realidad del aprendizaje de la asignatura, los recursos utilizados para estudiar y las posibles necesidades de innovación. Este diagnóstico sirvió de base para diseñar la propuesta del videojuego educativo. El mismo fue diseñado en tecnología 3D, mediante el motor gráfico del software UNITY. Esta versión del videojuego permite que el estudiante interactúe con cinco animales que en Venezuela están en peligro de extinción, cada uno de hábitat diferente: halcón primito (desierto), oso frontino (bosque), tortuga carey (playa), caimán del Orinoco (río) y cachicamo (montaña). Adicionalmente, se aportan sugerencias y recomendaciones para mejorar el aprovechamiento del videojuego.
РЕЗУЛЬТАТЫ ТЕХНИКО-ТЕХНОЛОГИЧЕСКОГО АНАЛИЗА КЕРАМИКИ ИЗ МОГИЛЬНИКА ШЕЛОМОК I, ПОСЕЛЕНИЙ КИЖИРОВО, САМУСЬ II
Authors: Pletneva Lyudmila , Ragimkhanova Irma , Stepanova Nadezhda 
Published: March 2020

Статья продолжает серию публикаций по результатам технико-технологического анализа керамики памятников раннего железного века Томского Приобья, относящихся к шеломокской культуре и к томскому варианту кулайской культурно-исторической общности. Для анализа были взяты фрагменты керамики из могильника Шеломок I, поселений Кижирово и Самусь II. Результаты анализов показали, как сходство, так и отличия в выборе исходного сырья и подготовки формовочных масс. Например, если для поселения Шеломок II – базового памятника шеломокской культуры, характерна примесь дресвы из гранита с белыми и прозрачными включениями кварца (Плетнёва, Степанова, 2018), то в формовочных массах керамики из могильника добавляли гранит с красными (розовыми) включениями кварца. Памятники эти расположены рядом, на расстоянии 500 м друг от друга, то есть природная среда была одинаковой. Датировка поселения Шеломок II укладывается в пределы V–III вв. до н. э., а могильника Шеломок I – IV–III вв. до н. э., что свидетельствует об их синхронном существовании.
Предметы из могильника находят ближайшие аналогии в материалах шеломокской культуры. Сравнение предметного ряда изделий из бронзы, кости и рога свидетельствует о контактах оставившего его населения с тагарцами Ачинско-Мариинской лесостепи, а также, возможно, с населением большереченской культуры, по мнению И. Ж. Рагимхановой и возможно, по мнению Л. М. Плетневой, материалы могильника отражают сложные культурные процессы раннего железного века, происходившие в Томском Приобье и фиксируют приход населения из Ачинско-Мариинского района тагарской культуры.This paper continues a series of publications that report the results oftechnical and technological analysis of ceramics from the Early Iron Age monuments of the Tomsk Ob Region, which are attributed to Shelomok and Tomsk variants of the Kulay cultural and historical community. Fragments of ceramics have been taken for analysis from the Shelomok I burial ground, Kizhirovo and Samus II settlements. The results of analysis demonstrate both similarities and differences in the choice of raw materials and the preparation of molding compounds. For example, the addition of granite gruss with white and transparent quartz inclusions to the pottery paste was typical of Shelomok II settlement (Pletneva, Stepanova, 2018), while the pottery paste from the burial ground included granite with red (pink) quartz inclusions. These monuments are located nearby, at a distance of 500 m away from each other, in the same natural environment. Perhaps, the materials of the burial ground reflect the complex cultural processes of the early Iron Age that took place in the Tomsk Ob region and record the arrival of the population from the Achinsk-Mariinsky district of tagar culture.
National Project “Culture” in the Focus of the 7th All-Russian Forum of Public Libraries
Authors: Basov Sergey A. 
Published: March 2020

The article describes the work of the 7th All-Russian Forum of Public Libraries “Municipal Libraries of New Generation: The Regional View”, which was held on November 15—16, 2019 in St. Petersburg. It became the main library platform of the 8th St. Petersburg International Cultural Forum. The organizers of the Forum were the National Library of Russia (NLR) and the Russian State Library (RSL) with the participation of the Russian Library Association (RLA). The Committee for Culture of St. Petersburg and the Mayakovsky Central City Public Library, Leningrad Regional Universal Scientific Library and St. Petersburg Library Society made significant contribution to the organization of the Forum.The Forum of public libraries considered the first results of implementation of the National project “Culture” in the field of creating the model libraries of the new generation. The author reveals the content of the main events of the Forum — the plenary session and round tables devoted to the specific features of working with readers and book collections: “Municipal libraries of new generation: exchange of experience and ideas”, “The Year of Daniil Granin in public libraries in Russia”, “Public library in civil society”. The article reflects the main ideas of presentations by specialists of various levels — from federal to municipal. The author shows the place of model libraries in the system of public municipal libraries, summarizes the first results of competitions among the municipal libraries of the country, as well as describes the characteristics of unresolved issues and identifies the main problems and directions of modernization of libraries. The article raises the question on the place of model libraries in the network of municipal libraries in the country. The article presents the final document of the Forum with appeal to the Ministry of Culture of the Russian Federation, to the RSL, the NLR and the RLA, as well as to the state authorities of the subjects of the Russian Federation, local authorities, central libraries of the subjects of the Russian Federation, municipal libraries together with project offices of the subjects of the Russian Federation and model libraries of new generation.
Programs for Preservation of the National Book Heritage in the Library Policy of the People’s Republic of China
Authors: Barysheva Ekaterina A. 
Published: March 2020

The purpose of the article is to summarize the information on the state of collections of ancient and rare books in the library institutions of the People’s Republic of China (PRC) by the beginning of the 21st century, to consider the content and the course of implementation of the state programs of the PRC in the field of registration, cataloguing, conservation, restoration, preservation and promotion of the national book heritage monuments. The author presents definitions of the terms “Ancient books” and “Rare books” used in China. All manuscript books and printed publications created before 1912 are considered Ancient books. Rare books include all books dated back to the period before 1795 and editions published in 1796—1912 that have outstanding historical, cultural, art and aesthetic value, as well as publishing products and documents from the period of the Republic of China (1912—1949). Chinese publications often use the term “Rare ancient books”, which refers to all manuscript books and printed publications before 1795. There are about 27 million 175 thousand copies of ancient books in the country’s libraries, including 2,5 million books created before 1795; and about 45 thousand ancient books have been preserved in a single copy.The article focuses on the programs developed with the participation of the National Library of China (NLC) and approved by the PRC Government in 2007—2018. The author reveals the main provisions of the “National Plan for Preservation of Ancient Books” (2007), as well as the powers and tasks of the National Centre for Conservation and Preservation of Ancient Chinese Books (NC), which has become the lead agency responsible for the implementation of the Plan. The paper considers the system of regional and local centres for the conservation and restoration of ancient and rare books, headed by the NC, that has developed in the PRC at present, shows the role of these centres in the field of identification, registration and cataloguing of book heritage monuments, in the creation and maintenance of a normative storage regime in old library buildings, ensuring the activities of restoration workshops, digitization of documents, preparation and online publication of full-text databases of ancient and rare books. The article emphasizes the importance of the National Museum of Classical Books, opened in July 2014 at the NLC, for promoting the national book heritage.The author notes that the priority task for the coming years is the construction of three new buildings of the National Book Depository in Beijing and Chéngdé (Hebei Province). The article concludes that over the past ten years, owing to the government support and targeted funding, China has managed to organize systematic activities in the field of conservation, preservation and promotion of the national book heritage.