bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF A PEAK GROUND ACCELERATION VALUE AND EARTHQUAKE INTENSITY USING DONOVAN METHOD IN BANTEN PROVINCE
Authors: Ariani Elsi 
Published: December 2020

Analysis of a peak ground acceleration value and earthquake intensity in Banten Province has been carried out using historical earthquake data from 2008 to 2018. This research aims to describe a prone area of the earthquake. The specification of data was a magnitude > 5 SR and the depth 0-70 km. The Donovan method was used to analyze peak ground acceleration value and the earthquake’s intensity. According to the data obtained, 31 earthquake points with a maximum earthquake strength occurred on October 16, 2019, with a depth of 10 km and a magnitude of 6.48 SR. This earthquake was located in Ujung Kulon with coordinates -6.81 LS and 105.113 BT. Based on data analysis result was obtained a peak ground acceleration value and the intensity of earthquake maximum in The Pandeglang Regency with a peak ground acceleration value was 211.56 cm/s2, and intensity of scale VIII and a large risk level of three. While a peak ground acceleration minimum is located in the South Tangerang City was 62.82 cm/s2 with a scale of intensity VII and a moderate risk level.
ANALISIS KESALAHAN SISWA DALAM PEMAHAMAN KONSEP OPERASI HITUNG PADA PECAHAN
Authors: Damayanti Nia Wahyu , Mayangsari Sizillia Noranda 
Published: December 2020

AbstrakPemahaman matematika sangat diperlukan siswa dalam menyelesaikan masalah matematika. Siswa dituntut untuk memahami konsep matematika agar dapat menyelesaikan masalah matematika dengan benar. Namun, pemahaman konsep yang dimiliki antar siswa berbeda-beda. Perbedaan ini muncul disebabkan adanya kesalahan siswa dalam memahami konsep matematika. Selain itu, kesalahan siswa terjadi karena adanya skema yang belum dimunculkan dalam menyelesaikan soal matematika. Penelitian ini bertujuan untuk menganalisis kesalahan siswa terhadap pemahaman konsep operasi hitung pada pecahan. Penelitian termasuk jenis penelitian kualitatif deskriptif. Berdasarkan hasil penelitian ini, kesalahan yang dilakukan siswa yaitu berupa kesalahan pemahaman konsep operasi hitung pecahan. Oleh karena itu peran guru dalam memfasilitasi siswa dalam memahami konsep matematika mutlak diperlukan.Kata Kunci: analisis kesalahan, operasi hitung, pecahan.
A Generalization of t-Practical Numbers
Authors: Baddai Saad abood 
Published: December 2020

This paper generalizes and improves the results of Margenstren, by proving that the number of -practical numbers which is defined by has a lower bound in terms of . This bound is more sharper than Mangenstern bound when Further general results are given for the existence of -practical numbers, by proving that the interval contains a -practical for all
Quantitative Linear Dichroism Imaging of Molecular Processes in Living Cells Made Simple by Open Software Tools
Authors: Bondar Alexey , Rybakova Olga , Melcr Josef , Dohnálek Jan , Khoroshyy Petro , Tichacek Ondrej , Timr Štěpán , Miclea Paul , Sakhi Alina , Lazar Josef 
Published: December 2020

Abstract
Fluorescence-detected linear dichroism microscopy allows observing various molecular processes in living cells, as well as obtaining quantitative information on orientation of fluorescent molecules associated with cellular features. Such information can provide insights into protein structure, aid in development of genetically encoded probes, and allow determinations of lipid membrane properties. However, quantitating and interpreting linear dichroism in biological systems has been laborious and unreliable. Here we present a set of open source ImageJ-based software tools that allow fast and easy linear dichroism visualization and quantitation, as well as extraction of quantitative information on molecular orientations, even in living systems. The tools were tested on model synthetic lipid vesicles, and applied to a variety of biological systems, including observations of conformational changes during G-protein signaling in living cells, using fluorescent proteins. Our results show that our tools and model systems are applicable to a wide range of molecular systems and polarization-resolved microscopy techniques, and represent a significant step towards making polarization microscopy a mainstream tool of biological imaging.
NEUBOrg: artificially induced pluripotent stem cell-derived brain organoid to model and study genetics of Alzheimer’s disease progression.
Authors: Esmail Sally , Danter Wayne 
Published: December 2020

Abstract
Alzheimer's disease (AD) is the most common type of neurodegenerative diseases. There are over 44 million people living with the disease worldwide. While there are currently no effective treatments for AD, induced pluripotent stem cell-derived brain organoids have the potential to provide a better understanding of Alzheimer’s pathogenesis. Nevertheless, developing brain organoid models is expensive, time consuming and often does not reflect disease progression. Using accurate and inexpensive computer simulations of human brain organoids can overcome the current limitations. Induced whole brain organoids (aiWBO) will greatly expand our ability to model AD and can guide wet lab research. In this study, we have successfully developed and validated artificially induced a whole brain organoid platform (NEUBOrg) using our previously validated machine learning platform, DeepNEU (v6.1). Using NEUBorg platform, we have generated aiWBO simulations of AD and provided a novel approach to test genetic risk factors associated with AD progression and pathogenesis.
Effect of Elective Induction of Labor on Pregnancy Outcome in Low-Risk Pregnant Women At or Beyond Later Than Term
Authors: Zhang Qinjian , Chen Siwen , Xu Xia , Zhang Huale , Yan Jianying 
Published: December 2020

Abstract
Background Singleton low-risk pregnant women without obstetric or medical complications,can expect to terminate pregnancy by selective induced labor until 41 weeks later.But recent researches showed it is reasonable to offer elective induction of labor to low-risk nulliparous women 39 weeks 0 days of gestation, and this recommend need further research be conducted to measure the impact of this practice.The fundamental question is whether this operation will increase the additional risk of mother and fetus. Objective To investigate the effect of induced labor on maternal and fetal pregnancy outcome.Methods The method of this study is a retrospective case-control study.In this study, a total of 4386 pregnant women with singleton low-risk who underwent regular prenatal examination and successful vaginal delivery at or more than 41 weeks 0 days of gestation in Fujian Maternal and Child Health Hospital from January 2014 to December 2018. Review the clinical data,according to the mode of labor initiation, they were divided into induced labor group (2007 cases) and spontaneous onset of labor group (2361 cases). Further stratified analysis was carried out according to age and parity. Two-sample independent t-test and χ 2 test were used to analyze the differences of clinical characteristics such as maternal age and parity between the two groups. Logistic regression model was used to analyze the effect of induced labor on pregnancy outcome.Results The total duration of labor in the induced labor group was significantly longer than that in the spontaneous onset of labor group[ (9.37±5.37)vs (8.82±5.13)h,P＜0.001],associated with more postpartum blood loss[ (219.18±188.32)vs (199.95±124.69)mL,P=0.01], and the incidence of severe postpartum hemorrhage(sPPH) was significantly higher[0.8%(16/2007) vs 0.33% (8/2361),P =0.041];increase but no significant difference in the incidence of postpartum hemorrhage(PPH) [3.8 %(77/2007) vs 2.8% (66/2361),P =0.054].However,operative vaginal birth was more common in the induced labor group[3.8 %(77/2007) vs 2.8% (66/2361),P =0.054].Compared with spontaneous onset of labor,NICU admissions were higher with induction[3.8 %(77/2007) vs 2.8% (66/2361),P =0.054];but not significantly increase the risk of the third degree amniotic fluid contamination,placental abruption,birth weight and its distribution, sex of newborn, incidence of neonatal brain injury, incidence of neonatal intraventricular hemorrhage, perinatal death, neonatal hyperbilirubinemia, neonatal septicemia, neonatal pneumonia and Apgar ≤ 7 at birth (P＞0.05). After adjusting for age, the operation of induced labor in nulliparous is more likely to occur PPH[2.74 %(55/2007) vs 1.65 %(39/2361);RR=1.557;95%CI:1.039~2.332,P＜0.05].Conclusion Selective induction of labor increases the complications of mother and child.Low-risk pregnant women should try to avoid induction without medical indications.
Impact of integrated genetic information on diagnosis and prognostication for myeloproliferative neoplasms in the next-generation sequencing era
Authors: Lee Jong-Mi , Lee Howon , Eom Ki-Seong , Lee Sung-Eun , Kim Myungshin , Kim Yonggoo 
Published: December 2020

Abstract

Background: Since next-generation sequencing has been widely used in clinical laboratory, diagnosis and risk stratification of hematologic malignancies are greatly dependent on genetic aberrations. Methods: In this study, we analyzed the genomic landscape of 200 patients with myeloproliferative neoplasms (MPNs) using targeted panel sequencing covering including 86 genes. Conventional BM karyotyping was also performed to determine chromosomal aberration. We analyzed relationships between genetic profiles and clinical outcomes including acute transformation, bone marrow fibrosis and death.Results: Mutations in JAK2, CALR, and MPL were detected in 76.4% of MPNs. The proportion of patients with clonal genetic markers increased up to 86.4% when all detectable genetic aberrations were included. Significant co-occurring genetic aberrations potentially associated with phenotype and/or disease progression, including those in JAK2/SF3B1 (P=0.017) and TP53/del(13q), del(5q), -7/del(7q) and complex karyotypes (P=0.038, P<0.001, P<0.001 and P<0.001, respectively) were detected. We also identified genetic aberrations associated with patient outcomes: TP53 and -7/del(7q) for inferior survival (HR, 95% CI: 64.2, 3.8-1096.5, P=0.0041, HR, 95% CI: 14.0, 1.5-132.7, P=0.0219), RUNX1, TP53 and IDH1/2 for leukemic transformation (HR, 95% CI: 68.1, 3.6-1300.4, P=0.005, HR, 95% CI: 16.3, 1.2-222.7, P=0.0364, HR, 95% CI: 32.5, 2.8-371.1, P=0.0051), SF2B1, IDH1/2, ASXL1 and del(20q) for fibrotic progression (HR, 95% CI: 31.5, 4.1-243.3, P=0.0009, HR, 95% CI: 21.2, 3.4-132.2, P=0.0011, HR, 95% CI: 4.3, 1.1-16.4, P=0.0358, HR, 95% CI: 44.5, 6.1-323.0, P=0.0002). We compared risk stratification systems and found that mutation-enhanced prognostic scoring systems could identify lower risk polycythemia vera and essential thrombocythemia and higher risk primary myelofibrosis (P<0.001, P<0.001 and P<0.001, respectively). Furthermore, the new risk stratification systems showed better predictive capacity of patient outcome. Conclusions: These results collectively indicate that integrated genetic information can enhance diagnosis and prognostication in patients with myeloproliferative neoplasms.
5335 Days of Implementation Science: Using Natural Language Processing to Examine Publication Trends and Topics
Authors: Scaccia Jonathan P. , Scott Victoria C. 
Published: December 2020

Abstract
Introduction: Moving evidence-based practices into the hands of practitioners requires the synthesis and translation of research literature. However, the growing pace of scientific publications across disciplines makes it increasingly difficult to stay abreast of research literature. Natural Language Processing (NLP) methods are emerging as a valuable strategy for conducting content analyses of academic literature. We sought to apply NLP to identify publication trends in the flagship journal field, Implementation Science, including key topic clusters and the distribution of topics over time. A parallel study objective was to demonstrate how NLP can be used in research synthesis. Methods: We examined 1711 Implementation Science abstracts published from February 22, 2006 to October 1, 2020. We retrieved the study data using PubMed’s Application Programming Interface (API) to assemble a database. Following standard preprocessing steps, we use topic modeling with latent Dirichlet Allocation (LDA) to cluster the abstracts following a minimization algorithm.Results: We examined 30 topics and computed topic model statistics of quality. Analyses revealed that published articles largely reflect i) characteristics of research, or ii) domains of practice. Emergent topic clusters encompassed key terms both salient and common to implementation science. HIV and stroke(s) represent the most commonly published clinical areas. Systematic reviews have grown in topic prominence and coherence, whereas articles pertaining to knowledge translation (KT) have dropped in prominence since 2013. Articles on HIV and implementation effectiveness have increased in topic exclusivity over time. Discussion. We demonstrated how NLP can be used as a synthesis and translation method to identify trends and topics across a large number of (over 1700) articles. With applicability to a variety of research domains, NLP is a promising approach to accelerate the dissemination and uptake of research literature. For future research in implementation science, we encourage the inclusion of more equity-focused studies to expand the impact of implementation science on disadvantaged communities.
Effect of Positive Hepatitis B Surface Antigen on The Risk of Synchronous Liver Metastasis: A Retrospective Study of 868 Consecutive Patients of Newly Diagnosed Gastric Cancer
Authors: Wang Tingya , Zhang Haijun 
Published: December 2020

Abstract
Background. The study aimed to explore the influence of hepatitis B virus (HBV) infection on the risk of synchronous gastric cancer liver metastasis (synGCLM).Methods. This was a retrospective study which enrolled 868 patients with newly diagnosed gastric cancer (GC). The study compared the prevalence of synGCLM between hepatitis B surface antigen (HBsAg)-positive (HBsAg+) and -negative (HBsAg-) patients. Logistic regression analysis was utilized to analyze the risk factors for synGCLM. Among patients with and without synGCLM, aspartate aminotransferase to platelet ratio index (APRI), liver fibrosis-4 index (FIB-4) and hepatitis B e antigen (HBeAg) status were further analyzed. Results. The prevalence of synGCLM in the HBsAg+ patients was higher than that in the HBsAg- patients, which was statistically significant (P = 0.025). Multivariate logistic regression analysis demonstrated that HBsAg, the elevated level of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), γ-glutamyltransferase (GGT) and alkaline phosphatase (ALP) were risk factors for synGCLM. Among the HBsAg+ patients, both ARPI and FIB-4 were significantly higher in the patients with synGCLM (synGCLM+) than those without synGCLM (synGCLM-) (ARPI: P = 0.045; FIB-4: P = 0.047); HBeAg positivity was detected in 20.0% of synGCLM+ patients compared to 6.0% of synGCLM- patients, but the difference was of no significance (P = 0.190). Conclusions. HBV infection significantly increases the risk of synGCLM, and elevated ARPI and FIB-4 may be pro-metastatic especially among the HBsAg+ GC patients.
Evaluation of Xa7 Introgressed Lines Against Bacterial Leaf Blight (BLB) Disease and Their Agronomic Performances
Authors: Yazid Siti Norhidaya , Ghaffar Mohd Bahagia Ab , Razak Shahril Ab , Rahman Zuraida Abd , Ramachandran Kogeethavani , Hashim Habibuddin , Mohamad Siti Nor Aziemah , Ahmad khairulmazmi 
Published: December 2020

Abstract
Bacterial leaf blight (BLB) is one of the major rice diseases in Malaysia. The disease can potentially cause a 30 to 50% yield loss to the rice crop. Hence, the utilization of resistant rice varieties to BLB is a crucial approach to prevent potential yield loss and to ensure the sustainability of the rice industry in Malaysia. This study aims to incorporate BLB resistant trait into a susceptible, high yielding, popular commercial variety MR219. The identified donor parent is IRBB7, harboring Xa7, a broad-spectrum BLB resistant gene which closely linked to two STS markers, the ID7 and ID15. Backcrossing was initiated, using IRBB7 as the donor and MR219 as the recurrent parents. Marker-assisted selection (MAS) was applied to monitor and confirm the introgression of Xa7 in the progenies of the cross based on alleles produced by the markers. We managed to generate 19 BC3F4 lines harboring homozygous Xa7 gene that were phenotypically resistant when challenged with Xanthomonas oryzae pv. oryzae through an artificial inoculation. The improved lines exhibited similar morphological and yield performance of the recurrent parent. Two lines, PB-2-107 and PB-2-34 were identified for their outstanding performances which are comparable to MR219. This study demonstrates the advantage of MAS application in the improvement of disease resistance traits in the elite rice cultivars.
Transcriptomic and Targeted Metabolomic Analysis Identifies Genes Controlling for Early Bolting and Flowering in Angelica Sinensis
Authors: Li Mengfei , Li Jie , Yao Ruyu , Jin Ling , Xing Hua , Yang Delong , Wei Jianhe , Paré Paul W. 
Published: December 2020

Abstract
Background: The root of the perennial herb Angelica sinensis is a widely used source for traditional Chinese medicines. While the plant thrives in cool-moist regions of western China, early bolting and flowering (EBF) for young plants, significantly reduces root quality and yield. Approaches to inhibit EBF by changes in physiology during the vernalization process have been investigated, however the mechanism for activating EBF has not been identified. Here, transcript profiles for bolted and unbolted plants (BP and UBP, respectively) are compared.Results: A total of over 72,000 unigenes were detected with ca. 2,600 differentially expressed genes (DEGs) observed in the BP compared with UBP. While various signaling pathways participate in flower induction, it is genes associated with floral development and the sucrose pathway that are observed to be coordinated in EBF plants, to coherently up and down regulate flowering genes that activate and inhibit flowering, respectively. Down-stream signal accumulation including gibberellic acids and sucrose metabolites were also monitored by HPLC-MS/MS for EBF plants.Conclusions: The signature transcripts pattern for the developmental pathways that drive flowering provides insight into the molecular signals that activate plant EBF.
The Feasibility of Anterior Occipital Condyle Screw for the Reconstruction of Craniovertebral Junction: A Digital Anatomical and Cadaveric Study of a Novel Technique
Authors: Xu Dingli , Mao Haijiao , Wang Yang , Gan Kaifeng , Ma Weihu 
Published: December 2020

Abstract
Background: Anterior occipital condyle screw (AOCS) could be a feasible technique apply to the reconstruction of craniovertebral junction. This study was to analyze the feasibility of AOCS.Method: The craniovertebral junction computed tomography (CT) scans of 40 adults were enrolled and imported into Mimics software. Then the three-dimensional reconstruction digital model of craniovertebral junction were established to determine entry point, insertion angle and screw’s trajectory. After AOCS inserted into ten human cadaver spine specimens, CT scans were performed to verify the location between screws and important structures. Result: The optimal entry point is located caudally and medial to the ventral of occipital condyle. The optimal trajectory is in inclination angle (5.9°±3.4°) in the sagittal plane and diverge angle (26.7°±6.0°) in the axial plane with the screw length around 21.6±1.2mm. There were no screws invaded into hypoglossal canal and vertebral artery in all specimens.Conclusion: AOCS fixation is a feasible novel technique for anterior craniovertebral junction reconstruction, and it could be an effective alternative operation for anterior reconstruction with titanium mesh cage.
Using Identification and Quantification to Decipher The Dynamic Changes of Main Chemical Components In The Processing of Stir-Frying Codonopsis Radix With Rice By HPLC-MS/MS
Authors: Wang Qinghao , Zheng Yinghao , Wang Yun , Yu Dingrong , Lei Zhenhong , Wang Yulong , Liu Tianliang , Zhang Cun 
Published: December 2020

Abstract
Background: Codonopsis Radix (CR) as the tonic Chinese herbis is good at benefiting Qi and promoting saliva, while rice-processed CR (RCR) can alleviate the original dryness and more specialize in invigorating the spleen and stopping diarrhea. Despite CR and RCR are long-standing medicines commonly used in clinic, information on their differences in substance basis is limited, let alone dynamic changes of their main chemical components. Given this, a more comprehensive understanding of processing principles in CR is needed.Methods: In this study, a strategy for rapid separation and identification of chemical constituents in crude CR and RCR was developed by HPLC-Q-TOF-MS/MS. Moreover, chemical constituents (lobetyolin and atractylenolide III) with significant content change were quantitatively determined by HPLC-QQQ-MS, 5-hydroxymethylfurfural (5-HMF) was quantified by HPLC, and codonopsis pilosula polysaccharides (CPPS) was measured by phenol-sulphuric acid method.Results: A total of 28 compounds were identified from CR and RCR, including 12 organic acids, 6 phenylpropanoids, 5 hexanol glycosides and hexylene glycosides, 2 polyacetylenes, 1 alcohol compound, 1 sesquiterpene and 1 aldehyde. In order to explore the dynamic changes from raw CR to processed RCR, the content of representative components in several samples collected during processing was determined. The quantitative results indicated that the contents of lobetyolin, atractylenolide III and CPPS were lower in RCR than these in CR, and 5-HMF was newly formed in processed products, which manifested chemical composition change before and after processing. Conclusions: Processing principles and dynamic changes of CR were preliminarily elucidated. Lobetyolin, atractylenolide III, 5-HMF and CPPS were recommended as quality markers to distinguish CR from RCR. Since the established method is rapid, accurate and readily applicable, it will be helpful for quality control and identification of crude CR and RCR.