bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced limbic microstructural integrity in functional neurological disorder
Authors: Diez Ibai , Williams Benjamin , Kubicki Marek R. , Makris Nikos , Perez David L. 
Published: November 2019

AbstractBackgroundFunctional neurological disorder (FND) is a condition at the intersection of neurology and psychiatry. Individuals with FND exhibit corticolimbic abnormalities, yet little is known about the role of white matter tracts in the pathophysiology of FND. This study characterized between-group differences in microstructural integrity, and correlated fiber bundle integrity with symptom severity, physical disability, and illness duration.MethodsA diffusion tensor imaging (DTI) study was performed in 32 patients with mixed FND compared to 36 healthy controls. Diffusion-weighted magnetic resonance images were collected along with patient-reported symptom severity, physical disability (Short Form Health Survey-36), and illness duration data. Weighted-degree and link-level graph theory and probabilistic tractography analyses characterized fractional anisotropy (FA) values across cortico-subcortical connections. Results were corrected for multiple comparisons.ResultsCompared to controls, FND patients showed reduced FA in the stria terminalis/fornix, medial forebrain bundle, extreme capsule, uncinate fasciculus, cingulum bundle, corpus callosum, and striatal-postcentral gyrus projections. Except for the stria terminalis/fornix, these differences remained significant adjusting for depression and anxiety. In within-group analyses, physical disability inversely correlated with stria terminalis/fornix and medial forebrain bundle FA values; illness duration negatively correlated with stria terminalis/fornix white matter integrity. A FND symptom severity composite score did not correlate with FA in patients.ConclusionsIn this first DTI study of mixed FND, microstructural differences were observed in limbic and associative tracts implicated in salience, defensive behaviors, and emotion regulation. These findings advance our understanding of neurocircuit pathways in the pathophysiology of FND.
The use of social–communicative cues to interpret ambiguous pronouns: Bilingual adults differ from monolinguals
Authors: Contemori Carla , Tortajada Fabiola 
Published: November 2019

AbstractWe examine the interpretation of ambiguous pronouns in Spanish–English bilingual adults, in contexts in which social–communicative cues (looking-only or looking-and-pointing) are used. In Experiment 1, we demonstrate that pronoun interpretation is guided by the first-mention bias, which is modulated by the presence of the social–communicative cues both in monolinguals and in bilinguals. In Experiment 2, we show that if the speaker using the social–communicative cues is a non-native speaker of English, bilinguals rely more strongly on the social–communicative cues than monolinguals. Experiment 3 shows that stronger reliance on social–communicative cues in bilinguals’ interpretations is not the result of more accurate speech comprehension. Our results demonstrate that the ability to utilize the looking-only and looking-and-pointing cues is not driven by a superior ability to accurately read social cues in bilingual adults. In addition, monolinguals show lower sensitivity to the speaker’s intent when the speaker is a non-native speaker of English.
Playing the white man’s tune: inclusion in elite classical music education
Authors: Griffiths Austin 
Published: November 2019

AbstractThis study examined the nature of inclusion for female and black and minority ethnic (BME) young people in elite-level classical music in England. By contrasting the numbers of female and BME students taking part in elite youth orchestras and music schools with the representation of female and BME compositions in the professional classical music repertoire, the study asked whether female and BME inclusion was limited to participation as performers or whether it included adequate representation in terms of the music performed. The survey analysed 4897 pieces from 681 composers drawn from the 2017/18 concert seasons of 10 major English orchestras, 1 week’s play lists from two classical music radio broadcasters and the programmes from the last four London Promenade seasons. The study found that female and BME students were well represented in elite music education, but they were very poorly represented in the professional repertoire, where 99% of performed pieces were by white composers and 98% by male composers. Applying Bourdieu’s concepts of doxa and illusio, the study concluded that inclusion in classical music in England allowed female and BME musicians to play, but structures in the field maintained a repertoire that continues to be white and male and does not recognise the contributions of female and BME composers. This suggests that inclusion for female and BME musicians is limited and the field continues to promote white and male dominance in its cultural values.
Toxoplasma gondii infection in children with lymphoma in Eastern China: seroprevalence, risk factors and case–control studies
Authors: Duan Yuhe , Zhi Yunlai , Liu Yusheng , Zhou Na , Li Fujiang , Hao Xiwei , Zhang Xiangyan , Dong Qian , Chen Lili 
Published: November 2019

Abstract
Epidemiological data for Toxoplasma gondii regarding malignancy have gained increasing attention; however, the information about T. gondii infection among children with malignant lymphoma (ML) in China is unclear. Therefore, 314 children with lymphoma and 314 healthy children, age- and gender-matched, were recruited to estimate the seroprevalence of T. gondii in the participants and identify the risk factors of infection. Blood samples from all participants were collected and examined for T. gondii IgG and IgM antibodies using ELISA. The results showed that the overall seroprevalence of T. gondii antibodies (including IgG and/or IgM) in ML patients and healthy controls was 19.8% and 9.9%, respectively. Contact with the cats, consumption of oysters and history of chemotherapy were estimated to be the risk factors for T. gondii infection in children with lymphoma by multivariable logistic regression analysis, whereas in healthy children, contact with cats and consumption of oysters were the risk factors. Moreover, among various histological types of lymphoma, individuals with NK/T-cell lymphoma, B-small lymphocytic lymphoma, marginal zone B-lymphoma and Hodgkin's lymphoma had a higher seroprevalence than healthy controls (P < 0.05). These findings indicated the high prevalence of T. gondii infection in children with lymphoma, and hence, efforts should be performed to evaluate the effect of the infection further in lymphoma patients.
Tricuspid atresia with absent pulmonary valve and intact ventricular septum: successful bidirectional cavopulmonary anastomosis with complete exclusion of the right ventricle
Authors: Lee Cheul , Kim Kyung Min , Lee Jae Young , Yoon Jihong 
Published: November 2019

AbstractTricuspid atresia with absent pulmonary valve and intact ventricular septum is an extremely rare cardiac malformation, historically associated with a poor prognosis. Only a few cases with successful surgical palliation have been reported in the literature. We present the case of an 8-month-old infant with this malformation who underwent successful bidirectional cavopulmonary anastomosis with complete exclusion of the right ventricle.
The Role of ‘Previous Generations’ in the Just Savings Principle of John Rawls
Authors: Pontin Ben 
Published: November 2019

AbstractThis article explores the shift in Rawls’ just savings principle away from an initial iteration that was indifferent to previous generational savings, to one in which past historical savings are the cornerstone of the motivation to save for future generations. Attention is given to the practical application of the revised principle in the field of the environment. The revised principle is argued to be an improvement on the initial one, because previous generations have an existence and identity that is more tangible than yet-to-be future ones.
Non-antimicrobial approaches at drying-off for treating and preventing intramammary infections in dairy cows. Part 1. Meta-analyses of efficacy of using an internal teat sealant without a concomitant antimicrobial treatment
Authors: Dufour Simon , Wellemans Vincent , Roy Jean-Philippe , Lacasse Pierre , Ordonez-Iturriaga Alfredo , Francoz David 
Published: November 2019

AbstractUse of antimicrobial approaches at drying-off for preventing new intramammary infections (IMI) during the dry period in dairy cows could be replaced by non-antimicrobial approaches. Such approaches would be of interest not only for organic but also for conventional dairy producers. The objective of the current review was to quantify the effect of non-antimicrobial internal teat sealant (ITS)-based approaches at drying-off for treating and preventing IMI, when compared with no treatment or with an antimicrobial-based approach. The protocol for this review was published before initiating the review. A total of 18 trials from 16 articles could be used to investigate the effect of an ITS-based approach. With the available results, we conclude with a high level of confidence that non-antimicrobial ITS-based dry-off approaches are efficient for preventing new IMI during the dry period when compared with no treatment, and would reduce risk of new IMI by 52%. Moreover, we are relatively confident that a bismuth subnitrate-based ITS performed better than an antimicrobial for preventing new IMI during the dry period (a risk reduction of 23%). Similarly, we are relatively confident that an ITS-based approach would only slightly or not at all reduce the prevalence of IMI at calving compared with untreated quarters.
Investigating the Accuracy of One‐Dimensional Volcanic Plume Models using Laboratory Experiments and Field Data
Authors: McNeal James S. , Freedland Graham , Mastin Larry G. , Cal Raúl Bayoán , Solovitz Stephen A. 
Published: November 2019

AbstractDuring volcanic eruptions, model predictions of plume height are limited by the accuracy of entrainment coefficients used in many plume models. Typically, two parameters are used, α and β, which relate the entrained air speed to the jet speed in the axial and cross‐flow directions, respectively. To improve estimates of these parameters, wind tunnel experiments have been conducted for a range of cross‐wind velocities and turbulence conditions. Measurements are compared directly to computations from the 1‐D plume model, Plumeria, in the near‐field, bending region of the jet. Entrainment coefficients are determined through regression analysis, demonstrating optimal combinations of effective α and β values. For turbulent conditions, all wind speeds overlapped at a single combination, α = 0.06 and β=0.46, each of which are slightly reduced from standard values. Refined coefficients were used to model plume heights for 20 historical eruptions. Model accuracy improves modestly in most cases, agreeing to within 3 km with observed plume heights. For weak eruptions, uncertainty in field measurements can outweigh the effects of these refinements, illustrating the challenge of applying plume models in practice.
Mechanistic Links Between the Sedimentary Redox Cycle and Marine Acid‐Base Chemistry
Authors: Reinhard Christopher T. , Fischer Woodward W. 
Published: November 2019

AbstractThe redox state of Earth's surface is controlled on geological timescales by the flow of electrons through the sedimentary rock cycle, mediated largely by the weathering and burial of C‐S‐Fe phases. These processes buffer atmospheric pO2. At the same time, CO2 influxes and carbonate burial control seawater acid‐base chemistry and climate over long timescales via the carbonate‐silicate cycle. However, these two systems are mechanistically linked and impact each other via charge balance in the hydrosphere. Here, we use a low‐order Earth system model to interrogate a subset of these connections, with a focus on changes that occur during perturbations to electron flow through the sedimentary rock cycle. We show that the net oxidation or reduction of the Earth's surface can play an important role in controlling acid‐base processes in the oceans and thus climate, and suggest that these links should be more fully integrated into interpretive frameworks aimed at understanding Earth system evolution throughout Precambrian and Phanerozoic time.
Electrical Conductivity of Omphacite as a Function of Water Content and Implications for High Conductivity Anomalies in the Dabie‐Sulu UHPM Belts and Tibet
Authors: Zhang Baohua , Zhao Chengcheng , Ge Jianhua , Yoshino Takashi 
Published: November 2019

AbstractMagnetotelluric surveys revealed high‐conductivity layers in the lower crust beneath Tibet and in the shallow part of the upper mantle relevant to continental collision extending to the Dabie‐Sulu ultrahigh‐pressure metamorphic (UHPM) belts of eastern China, which have been interpreted by the presence of aqueous fluids/partial melts or hydrous phases. However, these explanations are not consistent with their petrological features and seismic properties. Hydrogen‐bearing omphacite could be a probable candidate to explain such high‐conductivity anomalies due to its high water‐partitioning coefficient versus coexisting garnet in eclogite. In this study, we investigated electrical conductivities of Fe‐free and Fe‐bearing omphacite as a function of water content (0.005–0.122 wt.%) at 3 GPa and 500–1300 K. Our results show that water significantly enhances the electrical conductivity of omphacite, while iron facilitates conductivity by accelerating hydrogen diffusivity and lowering its activation enthalpy. Assuming a heat flow of 70 mW/m2, the high electrical anomalies observed beneath the Dabie‐Sulu UHPM belts and the Tibetan Plateau can be reasonably explained by omphacite containing 0.07 wt.% water since water content higher than 0.07 wt.% in omphacite was frequently reported in naturally collected eclogite.
A Damping Effect of the Maritime Continent for the Madden‐Julian Oscillation
Authors: Jiang Xianan , Su Hui , Waliser Duane E. 
Published: November 2019

AbstractThe damping effect of the Maritime Continent (MC) on propagation of the Madden‐Julian Oscillation (MJO) has been widely recognized; however, its underlying physics remains largely elusive. Capitalizing on the latest high‐resolution reanalysis data (ERA‐5) from the ECMWF, analyses in this study suggest that the interruption of lower‐tropospheric moistening over the MC land during MJO eastward propagation is mainly due to a drying effect induced by zonal advection of the low‐level winter mean moisture by MJO winds. The low‐level mean moisture pattern over the MC tends to closely follow local topography, with moisture maxima collocated with local mountain peaks. Given this mean moisture distribution, the moisture advection by anomalous easterly MJO winds corresponding to the active MJO convection over the eastern Indian Ocean will lead to a drying (moistening) effect to the east (west) of the mountain peaks. Diagnosis based on hourly output from ERA‐5 further illustrates that the diurnal cycle plays a crucial role for the formation of the topographically locked mean moisture pattern over the MC. This study, therefore, indicates that high‐resolution models capable of resolving detailed topography and associated diurnal cycle over the MC could be necessary for realistic depiction of the interaction between the MC and MJO.
Fine‐Particle Deposition, Retention, and Resuspension Within a Sand‐Bedded Stream Are Determined by Streambed Morphodynamics
Authors: Phillips Colin B. , Dallmann Jonathan D. , Jerolmack Douglas J. , Packman Aaron I. 
Published: November 2019

AbstractFine‐particle dynamics occupy an integral role in nutrient, contaminant, and pathogen transport in rivers. Due to low settling velocities, fine particles are often treated as if they pass through the river without interacting significantly with bed sediments. However, fine particles are advected toward and into the bed by turbulence and hyporheic exchange, leading to deposition by filtration. Extensive remobilization of fine particles is commonly observed during high flow conditions, but these dynamics are not well understood. Here we analyze the remobilization of fine tracer particles within the context of sediment morphodynamics during an experimental flood. Field data collected within Clear Run, a sand‐bedded stream, by Harvey et al. (2012, https://doi.org/10.1029/2012JG002043) represent subsurface and water column time series of solute and fine particulate tracers. Overhead time lapse photography of the motion and growth of bed forms during the flood are used to extract and quantify morphodynamics, which we relate to the resuspension of fine particles by transforming bed form wavelength statistics into scour depth through a set of geometric relations derived from laboratory experiments. Particles deposited near the bed surface such that scour from larger bed forms remobilized the majority of particles within the streambed (>72%) accounting for the increase in resuspended fine particles during the flood. This analysis demonstrates that the inclusion of bed form dynamics and scour is necessary for understanding the remobilization of fine particles in Clear Run and that interpreting fine‐particle dynamics during and beyond the event scale requires coupling with bed morphodynamics.
Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy
Authors: Qi Lihua , Chi Xiaochun , Zhang Xi , Feng Xueqian , Chu Wenhui , Zhang Shengchang , Wu Junzhou , Song Yao , Zhang Youyi , Kong Wei , Yu Yu , Zhang Hongquan 
Published: November 2019

AbstractKindlin-2 plays an important role in the regulation of cardiac structure and function. Depletion of Kindlin-2 contributes to cardiac hypertrophy and progressive heart failure, however, the precise mechanisms involved in this process remain unclear. GATA4 is a critical transcription factor in regulating cardiogenesis. We found that Kindlin-2 suppresses the expression of GATA4 through binding to its promoter and prevents cardiomyocytes from hypertrophy induced by isoproterenol (ISO) treatment. Mechanistically, Kindlin-2 interacts with histone methyltransferase SUV39H1 and recruits it to GATA4 promoter leading to the occupancy of histone H3K9 di- and tri-methylation. Furthermore, to confirm the function of Kindlin-2 in vivo, we generated mice with targeted deletion of cardiac Kindlin-2. We found that 6-month-old Kindlin-2 cKO mice have developed hypertrophic cardiomyopathy and that this pathological process can be accelerated by ISO-treatment. GATA4 expression was markedly activated in cardiac tissues of Kindlin-2 cKO mice compared to wild-type animals. Collectively, our data revealed that Kindlin-2 suppresses GATA4 expression by triggering histone H3K9 methylation in part and protects heart from pathological hypertrophy.
eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus
Authors: Li Yanrong , Jiang Weiyu , Niu Qiaona , Sun Yingjie , Meng Chunchun , Tan Lei , Song Cuiping , Qiu Xusheng , Liao Ying , Ding Chan 
Published: November 2019

AbstractNewcastle disease virus (NDV) causes severe infectious disease in poultry and selectively kills tumor cells, by inducing apoptosis and cytokines secretion. In this report, we study the mechanisms underlying NDV-induced apoptosis by investigating the unfolded protein response (UPR). We found that NDV infection activated all three branches of the UPR signaling (PERK-eIF2α, ATF6, and IRE1α) and triggered apoptosis, in avian cells (DF-1 and CEF) and in various human cancer cell types (HeLa, Cal27, HN13, A549, H1299, Huh7, and HepG2). Interestingly, the suppression of either apoptosis or UPR led to impaired NDV proliferation. Meanwhile, the inhibition of UPR by 4-PBA protected cells from NDV-induced apoptosis. Further study revealed that activation of PERK-eIF2α induced the expression of transcription factor CHOP, which subsequently promoted apoptosis by downregulating BCL-2/MCL-1, promoting JNK signaling and suppressing AKT signaling. In parallel, IRE1α mediated the splicing of XBP1 mRNA and resulted in the translation and nuclear translocation of XBP1s, thereby promoting the transcription of ER chaperones and components of ER-associated degradation (ERAD). Furthermore, IRE1α promoted apoptosis and cytokines secretion via the activation of JNK signaling. Knock down and overexpression studies showed that CHOP, IRE1α, XBP1, and JNK supported efficient virus proliferation. Our study demonstrates that the induction of eIF2α-CHOP-BCL-2/JNK and IRE1α-XBP1/JNK signaling cascades promote apoptosis and cytokines secretion, and these signaling cascades support NDV proliferation.
Longitudinal dataset of human-building interactions in U.S. offices
Authors: Langevin Jared 
Published: November 2019

AbstractAdaptive interactions between building occupants and their surrounding environments affect both energy use and environmental quality, as demonstrated by a large body of modeling research that quantifies the impacts of occupant behavior on building operations. Yet, available occupant field data are insufficient to explore the mechanisms that drive this interaction. This paper introduces data from a one year study of 24 U.S. office occupants that recorded a comprehensive set of possible exogenous and endogenous drivers of personal comfort and behavior over time. The longitudinal data collection protocol merges individual thermal comfort, preference, and behavior information from online daily surveys with datalogger readings of occupants’ local thermal environments and control states, yielding 2503 survey responses alongside tens of thousands of concurrent behavior and environment measurements. These data have been used to uncover links between the built environment, personal variables, and adaptive actions, and the data contribute to international research collaborations focused on understanding the human-building interaction.
Shotgun metagenome data of a defined mock community using Oxford Nanopore, PacBio and Illumina technologies
Authors: Sevim Volkan , Lee Juna , Egan Robert , Clum Alicia , Hundley Hope , Lee Janey , Everroad R. Craig , Detweiler Angela M. , Bebout Brad M. , Pett-Ridge Jennifer , Göker Markus , Murray Alison E. , Lindemann Stephen R. , Klenk Hans-Peter , O’Malley Ronan , Zane Matthew , Cheng Jan-Fang , Copeland Alex , Daum Christopher , Singer Esther , Woyke Tanja 
Published: November 2019

AbstractMetagenomic sequence data from defined mock communities is crucial for the assessment of sequencing platform performance and downstream analyses, including assembly, binning and taxonomic assignment. We report a comparison of shotgun metagenome sequencing and assembly metrics of a defined microbial mock community using the Oxford Nanopore Technologies (ONT) MinION, PacBio and Illumina sequencing platforms. Our synthetic microbial community BMock12 consists of 12 bacterial strains with genome sizes spanning 3.2–7.2 Mbp, 40–73% GC content, and 1.5–7.3% repeats. Size selection of both PacBio and ONT sequencing libraries prior to sequencing was essential to yield comparable relative abundances of organisms among all sequencing technologies. While the Illumina-based metagenome assembly yielded good coverage with few misassemblies, contiguity was greatly improved by both, Illumina + ONT and Illumina + PacBio hybrid assemblies but increased misassemblies, most notably in genomes with high sequence similarity to each other. Our resulting datasets allow evaluation and benchmarking of bioinformatics software on Illumina, PacBio and ONT platforms in parallel.