bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using and index of wellbeing for older people in small areas of Australia to assist identifying services required
Authors: Miranti Riyana , Tanton Robert , Vidyattama Yogi , Tuli Sajeda 
Published: January 2020

Abstract
Background: For older people, place is crucial as it is where support networks, social relationships and family are. Older people develop a sense of belonging to their local community through participation and place is strongly linked to personal histories. For older people, ageing in their own home also allows for continuity of relationships and informal support networks in the area.While there are significant benefits of ageing in place, for older people with low wellbeing, the provision of services is going to be essential to allow them to age in place. Therefore, this article aims to identify areas where older people have low wellbeing using an index of wellbeing developed using a range of data; and to show how the domains and indicators can be used to identify why older people in an area have low wellbeing. This analysis can then be used to help to identify what types of services are required to improve wellbeing in an area of low wellbeing best. Methods: We use Principal Components Analysis (PCA) to create the Index of Wellbeing for Older Australians, for each domain and then adding the domains together using a transformation. One of the advantages of this method is that areas can be identified as having low wellbeing, but then using the domains, the reason for the low wellbeing can be identified.A case study is used to show how low wellbeing can be attributed to a particular domain in the area; and then show how the indicators that were used for this domain can be used to identify exactly what is driving the low wellbeing for older people in the area.Results: Our overall findings show that the participation domain matters as the proportion of older people who are volunteers has the highest contribution to the well being index followed closely by the employment rate of older people. In contrast, functional ability domain reveals the need for assistance indicator has the highest contribution to reduce the wellbeing. Conclusion: We conclude that the index method used encourages the de-construction of the overall index, and provides a way to inform service providers in an area on the most effective ways to enhance wellbeing for older people in an area.
Duloxetine induced neural cell death and promoted neurite outgrowth in N2a cells
Authors: Gao Wanli , Chen Rui , Xie Nan , Tang Daolin , Zhou Borong , Wang Ding 
Published: January 2020

Abstract
Background: Duloxetine is a clinical drug that is primarily used for treatment of depression and pain, but it has side effects of addiction and tolerance. Cytochrome P450 (CYP) is its metabolic enzyme, and the drug’s biofunction results from its neuro-protective effect in animal and cell models. We aimed to investigate the duloxetine-induced neural cytotoxicity effect and its performance in an N2a cell neurite outgrowth model.Methods: Cell death was assessed as cell viability using a Cell Count Kit-8 and further evaluated using bright field images, propidium iodide (PI) and annexin V staining, colony formation analysis, TUNEL staining of the cells and biochemical testing. N2a cells were committed to differentiation by serum withdrawal and RA induction, and the neurite outgrowth was evaluated as the number of differentiated cells, longest neurite length and average neurite length. Cell cycle analysis, PI and annexin V staining and biochemical testing were used to evaluate the drug effects on differentiation.Results: The induction of neural cell death by duloxetine was not affected by classic cell death inhibitors but was promoted by the CYP inducer rifampicin. N2a cell neurite outgrowth was promoted by duloxetine via reduction of the CYP2D6 and MDA levels.Conclusions: Duloxetine induces neural cell death through effects on CYP and promotes N2a cell neurite outgrowth by regulating CYP and the intracellular lipid peroxidation level.
Exosome-mediated miR-1290 regulation of SLU7 affects hepatocellular carcinoma process
Authors: Li Fuyong , Fan Tingyong , Zhang Hao , Sun Yumin 
Published: January 2020

Abstract
Objective: Liver cancer, as a very common malignant tumor in clinic, has a high incidence rate and a poor prognosis. Understanding the relationship of exosomes miR-1290 and SLU7 with liver cancer may be a breakthrough in the diagnosis and treatment of liver cancer in the future.Methods: Altogether 64 patients with liver cancer and 58 healthy people in Shandong Cancer Hospital affiliated to Shandong University were collected, and liver cancer cells were purchased. qPCR was used to detect the mRNA levels of miR-1290 and SLU7. Western blot was used to detect the relative expression of SLU7 protein, and the effect of exosomes miR-1290 and SLU7 on the biological behavior of liver cancer cells was analyzed. Double fluorescein reporter was used to verify the targeted relationship between miR-1290 and SLU7.Results: miR-1290 was highly expressed in liver cancer (P< 0.050) and SLU7 was poorly expressed in liver cancer (P< 0.050). Exosomes miR-1290 could inhibit the relative expression of SLU7 protein (p < 0.050), promote the proliferation, invasion, migration and epithelial-mesenchymal transformation of liver cancer cells, and reduce the ability of apoptosis (P< 0.050). Double luciferase report and rescue experiment confirmed that miR-1290 and SLU7 had targeted relationship (P< 0.050).Conclusion: Exosomes miR-1290 may be a potential target for the diagnosis and treatment of liver cancer in the future through targeting inhibition of SLU7 in the occurrence and development of liver cancer.
Association between Muscular Strength and Depressive Symptoms among Chinese Nursing Freshmen—A Cross-Sectional Study
Authors: Guo Liya , Cao Jianhua , Li Yingke , Yang Guang , cheng peng , Hao Zongji , Yao Hui , Shi Dongzhe , Chen Chang , Peng Li , Ren Zhongyu 
Published: January 2020

Abstract
Increased physical activity level is related to lower risk of depressive symptoms, and an inverse association between muscular strength and risk of depressive symptoms among the elderly population. However, the association among younger adults is unclear. The aim of this study was to examine the association between muscle strength, using handgrip strength as a representative of skeletal muscle strength, and the risk of depressive symptoms among Chinese female college freshman. A cross-sectional study was conducted among 867 participants aged between 16-23 years. Handgrip strength was measured with a handheld digital Smedley dynamometer, and depressive symptoms were evaluated using the 20-item Zung self-rating depression scale (SDS) with 3 cut-off points to indicate elevated depressive symptoms. We found that 10.7% of participants (17.2% or 29.2%) were classified as having moderate to severe depressive symptoms using 50 as the cut-off point. After adjusting for these potential confounders, the adjusted odds ratios for moderate-to-severe depressive symptoms across tertile of relative handgrip strength were 1.00 (reference) for tertile 1, 0.61 (95% CI: 0.35, 1.04) for tertile 2, and 0.53 (95% CI: 0.39, 0.94) for tertile 3 (P for trend: 0.024). The significant associations remained when other cut-off points (SDS 48 or 45) were used. Interactions between the handgrip strength and potential confounders for depressive symptoms in the final models were insignificant. This study showed that handgrip strength is inversely and independently related to the risk of depressive symptoms among Chinese female college freshman. These results can help with the development of an effective intervention strategy against depression. For future research, it is important to explore the causality of the effects of handgrip strength on the depressive symptoms by intervention study.
Analysis of molecular mechanism for acceleration of polyembryony using gene functional annotation pipeline in Copidosoma floridanum
Authors: Sakamoto Takuma , Nishiko Maaya , Bono Hidemasa , Nakazato Takeru , Yoshimura Jin , Tabunoki Hiroko , Iwabuchi Kikuo 
Published: January 2020

Abstract
Background: Polyembryony is defined as the formation of several embryos from a single egg. This phenomenon can occur in humans, armadillo, and some endoparasitoid insects. However, the mechanism underlying polyembryogenesis in animals remains to be elucidated. The polyembryonic parasitoid wasp Copidosoma floridanum oviposits its egg into an egg of the host insect; eventually, over 2,000 individuals will arise from one egg. Previously, we reported that polyembryogenesis is enhanced when the juvenile hormone (JH) added to the culture medium in the embryo culture. Hence, in the present study, we performed RNA sequencing (RNA-Seq) analysis to investigate the molecular mechanisms controlling polyembryogenesis of C. floridanum . Functional annotation of genes is not fully available for C.floridanum ; however, whole genome assembly has been archived. Hence, we constructed a pipeline for gene functional annotation in C. floridanum and performed molecular network analysis. We analyzed differentially expressed genes between control and JH-treated molura after 48 h of culture, then used the tblastx program to assign whole C. floridanum transcripts to human gene.
Results: We obtained 11,117 transcripts in the JH treatment group and identified 217 differentially expressed genes compared with the control group. As a result, 76% of C. floridanum transcripts were assigned to human genes. Gene enrichment analysis revealed genes associated with platelet degranulation, fatty acid biosynthesis, cell morphogenesis in the differentiation and integrin signaling pathways were fluctuated following JH treatment. Furthermore, Cytoscape analysis revealed a molecular interaction that was possibly associated with polyembryogenesis .
Conclusions: We have constructed a pipeline for gene functional annotation of C. floridanum , and identified transcripts with high similarity to human genes during early embryo developmental. Additionally, this study reveals new molecular interactions associated with polyembryogenesis; these interactions could indicate the molecular mechanisms underlying polyembryony. Our results highlight the potential utility of molecular interaction analysis in human twins.
MISSION TO MARS: RADIATION SAFETY OR RADIATION DISASTER? SPACE TRANSIT AND MARS RADIATION EXPOSURE RISKS – THE POTENTIAL SHIELDING EFFECT OF AN INTRAVEHICULAR GRAPHENE SPACE SUIT AND A STORM SHELTER DURING SPACE TRAVEL
Authors: Squire Tim , Buchanan Grant , Elsaleh Hany 
Published: January 2020

ABSTRACT

Aim
The purpose of this research was to employ radiobiological as well as physics principles to investigate materials for an intravehicular spacesuit and a “storm shelter” that might minimize radiation exposure to astronauts during a mission to Mars.

Methods
NASA’s OLTARIS space radiation modelling tool was used to investigate thirty-two potential shielding materials. Radiation exposure was estimated during a return transit to Mars of 360 days duration. We assessed each shielding material by its ability to decrease effective radiation dose received by a computerized phantom during the constant galactic cosmic radiation (GCR) and a single solar particle event (SPE). For the “storm shelter” a large liquid fuel tank was modelled adjacent to the phantom during a SPE.

Results
At standard conditions, graphene appeared to be a promising shielding material when comparing other materials including polyethylene and lithium. The shielding efficacy became comparable to polyethylene but inferior to lithium when materials were normalised to 10g/cm2, 20g/cm2 and 30g/cm2. The graphene around the phantom reduced effective dose from GCR compared with an unshielded transit by 34% (162mSv/yr vs 213.3mSv/yr). A “storm shelter” using a liquid fuel tank was positioned to create a barrier adjacent to the astronauts. The liquid barrier reduced effective dose by 98.8% (44mSv vs 3614mSv). Other mitigation strategies were deduced and divided into launch, transit and habitation considerations.

Conclusion
A graphene based intravehicular suit could decrease astronaut exposure to harmful radiation during transit to Mars. A storm shelter using fuel as a barrier also decreased radiation dose during a solar particle event.
Genetic and Epigenetic Factors of E3/E3 Genotypes of APO-E Gene as a Strong Predictor for the Diagnosis of Coronary Artery Disease Patients of South India
Authors: Tantray Javeed Ahmad , Reddy Karnati Pratap , Jamil Kaiser , Lone Waseem Gul , Yerra Shiva Kumar 
Published: January 2020

Background:
The role of Apolipoprotein-E (APO-E) in lipid metabolism and cholesterol
transport is a key component of lipid metabolism which plays a role in diseases like hypercholesterolemia,
diabetes, and cardiovascular disease. The aim of this study was to determine the genotypes, allelic
frequencies, gene expression and methylation related to apolipoprotein E polymorphism in Coronary Artery
Disease (CAD) patients and compare with non-CAD healthy subjects of South Indian population.

Methods:
The APO-E alleles and genotypes were determined by PCR-RFLP. Gene expression profiles
for E3/E3 genotypes were determined using RT-PCR and methylation status was determined using
Methyl Specific PCR assay in one hundred patients and an equal number of controls.

Results:
Four APO-E genotypes (E4/E4, E3/E3, E3/E4, and E2/E3) were identified with different allele
frequency. Among these, E3/E3 genotype and E3 allele were found to be significantly higher in
cases than controls. The present study showed that the mRNA expression of APO-E was up-regulated
in CAD patients with E3/E3 genotype in comparison with controls. Methylation status indicated a significant
association of E3/E3 genotypes with the disease.

Conclusion:
Different populations studied worldwide showed inherent variable frequencies of the
APO-E alleles and genotypes, with the most frequent allele being E3. In this study, the APO-E genotypes
E2/E3/E4 showed variable response to CAD, further, there was a significant association of E3/E3
genotypes to CAD risk; this genotype can be suggested for the diagnosis of CAD.
<b>Primer registro del murciélago desértico sureño (</b><i>Bauerus dubiaquercus</i><b>) en el Estado de Tabasco, México</b>
Authors: García Morales Rodrigo , Santiago-Plata Víctor Manuel , Pérez-Garduza Freddy , Pérez-Netzahual Elizabeth , Ricardez-Ines María Cristina 
Published: January 2020

Resumen El murciélago pálido tropical (Bauerus dubiaquercus) es una especie poco conocida. Existe escasa información sobre su distribución en México, encontrándose sólo registros esporádicos en los estados de Campeche, Guerrero, Nayarit, Quintana Roo y Veracruz. En septiembre de 2017 se capturó y fotografió un ejemplar de B. dubiaquercus en el ejido Niños Héroes, municipio de Tenosique de Pino Suarez, Tabasco, México. Éste se localiza dentro del área natural protegida Cañón del Usumacinta y representa el primer registro documentado de la especie en Tabasco y el más reciente en la región sureste de México, lo que contribuye al conocimiento de la especie. Palabras clave: Área Natural Protegida, Chiroptera, selva mediana perennifolia, Vespertilionidae AbstractThe southern desert bat (Bauerus dubiaquercus) it’s a little known species. There is little information about its distribution in Mexico, with sporadic records in the states of Campeche, Guerrero, Nayarit, Quintana Roo and Veracruz. In September 2017, an individual of B. dubiaquercus was captured and photographed in the Ejido Niños Héroes, municipality of Tenosique de Pino Suarez, Tabasco, Mexico. This is located within the protected natural area Cañon del Usumacinta and represents the first documented record in Tabasco of the species and the most recent in the southeast region of Mexico, thus contributing to the knowledge of the species. Key words: Chiroptera, medium evergreen forest, natural protected area, Vespertilionidae
О значениях гипергеометрической функции с параметром из квадратичного поля
Authors: Иванков Павел Леонидович 
Published: January 2020

Для исследования арифметических свойств значений обобщенных гипергеометрических функций с рациональными параметрами обычно применяют метод Зигеля. Этим методом были получены наиболее общие результаты, относящиеся к упомянутым свойствам.Основной недостаток метода Зигеля состоит в невозможности его применения к гипергеометрическим функциям с иррациональными параметрами. В этой ситуации исследование обычно основывается на эффективной конструкции функциональной приближающей формы (в методе Зигеля существование такой формы доказывается с помощью принципа Дирихле). Построение и исследование приближающей формы является первым шагом в сложном рассуждении, которое ведет к получению арифметического результата.Используя эффективный метод, мы сталкиваемся по крайней мере с двумя проблемами, которые в значительной степени сужают область его применимости. Во-первых, неизвестна более или менее общая конструкция приближающей формы для произведений гипергеометрических функций. Используя метод Зигеля, мы не имеем дела с такой проблемой. По этой причине приходится рассматривать лишь вопросы линейной независимости над тем или иным алгебраическим полем. Выбор этого поля является второй проблемой.Подавляющее большинство опубликованных результатов, относящихся к рассматриваемому кругу задач, имеет дело с мнимым квадратичным полем (или с полем рациональных чисел). Лишь в отдельных случаях удается провести соответствующее исследование для какого-либо другого алгебраического поля.Мы рассматриваем здесь случай вещественного квадратичного поля. С помощью специального технического приема мы устанавливаем линейную независимость значений некоторой гипергеометрической функции с иррациональным параметром над таким полем.
О численной оценке эффективных характеристик периодических ячеистых структур с использованием балочных и оболочечных конечных элементов с помощью CAE Fidesys
Authors: Левин Владимир Анатольевич , Зингерман Константин Моисеевич , Яковлев Максим Яковлевич , Курденкова Екатерина Олеговна , Немтинова Диана Владимировна 
Published: January 2020

Развитие аддитивных технологий (3D-печати) сделало возможным изготовление деталей и изделий регулярной пористой и ячеистой структуры (с целью облегчения конструкции). При этом характерный размер ячейки намного меньше масштаба целого изделия. Численные прочностные и смежные с ними расчёты подобных конструкций требуют предварительной оценки эффективных характеристик такой ячеистой структуры. В данной статье представлена методика численной оценки эффективных упругих характеристик регулярных ячеистых структур, основанная на численном решении краевых задач теории упругости на ячейке периодичности. К ячейке последовательно прикладываются различные периодические граничные условия в виде связей, наложенных на перемещения противоположных граней ячейки. Для каждого вида граничных условий решается краевая задача теории упругости, полученное в результате решения которой поле напряжений осредняется по объёму. Эффективные свойства ячеистого материала оцениваются в виде обобщённого закона Гука.В работе рассматриваются композиционные материалы на основе жёсткого решётчатого каркаса, заполненного более мягким материалом. Расчёты проводятся методом конечных элементов с помощью отечественной CAE-системы «Фидесис». При этом в ряде расчётов для моделирования решётчатого каркаса используются конечные элементы балочного типа. В некоторых расчётах, помимо каркаса и матрицы, учитывается наличие тонкого слоя связующего между ними. Этот слой моделируется при помощи конечных элементов оболочечного типа.Приводятся графики сравнения результатов расчётов композиционных материалов с решётчатым каркасом с моделированием каркаса балочными элементами и результатов аналогичных расчётов, в которых каркас моделируется трёхмерными конечными элементами. Также приводятся графики сравнения результатов расчётов, в которых слой связующего моделируется оболочечными элементами, с результатами аналогичных расчётов, в которых связующее моделируется трёхмерными элементами. Графики показывают, что при достаточно тонких элементах каркаса (либо при достаточно тонком слое связующего) результаты получаются довольно близкими, что подтверждает применимость балочных и оболочечных элементов для численного решения таких задач.
CRIAÇÃO E RECRIAÇÃO LEXICAL NA ESFERA POLÍTICA: UMA ANÁLISE DOS NEOLOGISMOS RELACIONADOS À ELEIÇÃO 2018
Authors: Pereira Aline Maria Santos 
Published: January 2020

A língua está em constante processo de transformação, sendo, portanto, heterogênea e mutável; essas mudanças estão relacionadas aos contextos de uso e, consequentemente, às necessidades de comunicação dos interlocutores; nessa direção, os neologismos suprem essas necessidades e são frequentes na língua. Ante o exposto, a presente pesquisa tem como objetivo geral analisar os neologismos criados durante a campanha eleitoral 2018; como objetivos específicos, identificar o tipo de neologismo presente nos novos vocábulos; analisar os processos morfológicos utilizados na construção; observar se há correlação entre a forma e o sentido atribuído e evidenciar que alguns neologismos são efêmeros e outros são incorporados no léxico da língua. A pesquisa é qualitativa e compreendeu os seguintes passos: seleção dos vocábulos; estabelecimento de critérios de inclusão e exclusão; análise dos vocábulos em dois dicionários e no Vocabulário Ortográfico da Língua Portuguesa (VOLP); e, por fim, análise dos neologismos; foram analisados sete vocábulos utilizados em diferentes gêneros textuais divulgados no âmbito digital. O referencial teórico compreende, dentre outros, Câmara Júnior (2013), Laroca (2011), Alves (1994; 2001) e Correia e Almeida (2012). A pesquisa evidenciou: (i) a ocorrência maior da neologia estilística em detrimento da denominativa; (ii) ocorrências da neologia formal e da semântica, com presença maior para a formal; (iii) os processos utilizados perpassam pela derivação e pela composição, com destaque para os tipos: sufixal, truncamento e justaposição (iv) correlação entre a forma e o sentido, e, por fim, (v) a presença de algumas marcas, como aspas, para evidenciar a utilização de um novo termo.
O MUNDO ZOO EM CLARICE LISPECTOR
Authors: Silva Lorena Pereira , Andrade Maria das Graças Fonseca 
Published: January 2020

Autora de obras importantes que reverberam até hoje, tais como Perto do coração selvagem, A paixão segundo G.H., Água Viva e A hora da estrela, Clarice Lispector é um dos nomes de maior relevância no cenário da literatura brasileira. Desde suas primeiras composições, a autora demonstra uma relação extremamente próxima e empática com os animais chegando, muitas vezes, a legar-lhes total protagonismo. Lispector, engenhosamente, constrói suas narrativas de modo a aproximar humano e animal, esferas aparentemente tão distintas entre si. Interessa-nos, aqui, analisar como isso aparece em Uma aprendizagem ou O livro dos prazeres – sexto romance de sua carreira. Para tanto, traçaremos um percurso capaz de assegurar ao leitor a aproximação homem-animal, bem como suas reincidências, nos escritos claricianos. Com esse intuito, abordaremos alguns de seus contos, crônicas e livros dedicados ao público infantil, nos quais o humano é representado através do animal e que, por essa razão, entendemos como pertinentes, dados os objetivos deste artigo.
PALAVRAS-CHAVE: Animais; Clarice Lispector; Humano; Representação; Uma aprendizagem ou O livro dos prazeres.