bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internações de adolescentes por transtornos mentais e comportamentais e coberturas dos principais dispositivos de tratamento da rede
Authors: Bertelli Ellen Vanuza Martins , Oliveira Rosana Rosseto de , Higarashi Ieda Harumi 
Published: December 2020

O presente estudo buscou verificar a correlação entre as taxas de internação por transtornos mentais e comportamentais em adolescentes e a cobertura por CAPS, ESF e distribuição de leitos no estado do Paraná. Trata-se de um estudo ecológico, no período de 2008 a 2015. Para os cálculos de correlação utilizou-se o coeficiente de Spearman com nível de significância de 5%. Houve avanço na cobertura de CAPS e ESF em todo o estado, e redução dos leitos de internamento. Correlação forte entre cobertura de CAPS e internação psiquiátrica apenas na regional de Pato Branco (r=0,99; p<0,001) e Londrina (r=0,73; p=0,038), nas demais não houve significância estatística. A regional de Ponta Grossa (r=-0,76; p=0,028) e Irati apresentaram correlação forte (r=-0,70; p= 0,021) entre as taxas de internação e cobertura de ESF, respectivamente. Apenas regional de União da Vitória apresentou correlação forte entre leitos de tratamento e taxa de internação (r=0,7; p=0030). Identificou-se avanços na cobertura de CAPS e ESF em todo o estado, porém, não resultaram grandes resultados na diminuição das internações por transtornos mentais e comportamentais de adolescentes no Paraná.
Potencialidades e vulnerabilidades do programa de hipertensão: um estudo de revisão
Authors: Oliveira Jeane Suely Queiroz de , Valentim Lívia de Aguiar , Fernandes Franciane de Paula , Oliveira Sheyla Mara Silva de , Quaresma Tatiane Costa 
Published: December 2020

As ações de saúde empregadas no programa compreendem consultas médicas anuais ou trimestrais, conforme protocolo, que incluem esclarecimentos e orientações condizentes com hipertensão arterial, orientações e medidas de pressão arterial pela equipe de enfermagem, reuniões e palestras realizadas por unidade e dispensação de medicamentos, mas ainda encontramos baixa adesão ao tratamento, por isso, o presente estudo pretendeu avaliar os motivos que levam à baixa adesão, por meio de um estudo bibliográfico sobre os trabalhos científicos publicados por alunos de graduação da Universidade do Estado do Pará, onde foram encontrados como principais problemas de serviços, infraestrutura, alta demanda nos serviços de saúde, informações relacionadas à importância do atendimento domiciliar sobre esta doença, entre outros, o que nos leva a concluir que deve haver melhoria contínua da equipe de saúde, a partir do agentes, técnicos e profissionais do ensino superior, de modo que ao ter c contato com esses indivíduos um infectado por um processo crônico, é possível aceitar e atender a demanda para que aumente a adesão.
Adult Body Height and Cardiometabolic Disease Risk: The China National Health Survey in Shaanxi
Authors: Yuan Yuan , Zhou Bo , Wang Shunan , Ma Jia , Dong Fen , Yang Min , Zhang Zhixin , Niu Wenquan 
Published: December 2020

ObjectivesBased on data from the China National Health Survey, we aimed to examine the association between body height and cardiometabolic disease (CMD) in a large adult population from Shaanxi province, and further to test whether this association was hinged upon other population characteristics.MethodsThis population-based study was conducted in 2014 in Shaanxi Province, China. Utilizing a multi-stage stratified cluster sampling method, total 5,905 adults with complete data were eligible for analysis, and 1,151 (19.5%) of them had CMD. Of 1,151 CMD patients, 895 (15.1%) had one disorder and 256 (4.4%) had ≥2 disorders.ResultsUsing the bi-directional stepwise method and all-subsets regression, five factors—age, body mass index, family histories of CMD, exercise, and height—constituted the optimal model when predicting CMD risk. Restricted cubic spline regression showed a reduced tendency towards CMD with the increase of body height, with per 10 cm increment in body height corresponding to 14% reduced risk. Ordinal Logistic regression supported the contribution of body height on both continuous and categorical scales to CMD risk before and after adjustment, yet this contribution was significantly confounded by exercise and education, especially by exercise, which can explain 65.4% of total impact. For example, short stature was associated with an increased risk of CMD after multivariable adjustment not including exercise and education (odds ratio, 95% confidence interval, P: 1.42, 1.21 to 1.66, &lt;0.001), and tall stature was associated with a reduced risk (0.77, 0.64 to 0.92, 0.003).ConclusionsOur findings indicate short stature was a risk factor, yet tall stature was a protective factor for CMD in Chinese. Notably, the prediction of short and tall stature for CMD may be mediate in part by exercise.
Identification and Validation of Two Lung Adenocarcinoma-Development Characteristic Gene Sets for Diagnosing Lung Adenocarcinoma and Predicting Prognosis
Authors: Liu Cheng , Li Xiang , Shao Hua , Li Dan 
Published: December 2020

Background: Lung adenocarcinoma (LUAD) is one of the main types of lung cancer. Because of its low early diagnosis rate, poor late prognosis, and high mortality, it is of great significance to find biomarkers for diagnosis and prognosis.Methods: Five hundred and twelve LUADs from The Cancer Genome Atlas were used for differential expression analysis and short time-series expression miner (STEM) analysis to identify the LUAD-development characteristic genes. Survival analysis was used to identify the LUAD-unfavorable genes and LUAD-favorable genes. Gene set variation analysis (GSVA) was used to score individual samples against the two gene sets. Receiver operating characteristic (ROC) curve analysis and univariate and multivariate Cox regression analysis were used to explore the diagnostic and prognostic ability of the two GSVA score systems. Two independent data sets from Gene Expression Omnibus (GEO) were used for verifying the results. Functional enrichment analysis was used to explore the potential biological functions of LUAD-unfavorable genes.Results: With the development of LUAD, 185 differentially expressed genes (DEGs) were gradually upregulated, of which 84 genes were associated with LUAD survival and named as LUAD-unfavorable gene set. While 237 DEGs were gradually downregulated, of which 39 genes were associated with LUAD survival and named as LUAD-favorable gene set. ROC curve analysis and univariate/multivariate Cox proportional hazards analyses indicated both of LUAD-unfavorable GSVA score and LUAD-favorable GSVA score were a biomarker of LUAD. Moreover, both of these two GSVA score systems were an independent factor for LUAD prognosis. The LUAD-unfavorable genes were significantly involved in p53 signaling pathway, Oocyte meiosis, and Cell cycle.Conclusion: We identified and validated two LUAD-development characteristic gene sets that not only have diagnostic value but also prognostic value. It may provide new insight for further research on LUAD.
An Early Increase of Blood Leukocyte Subsets in Aneurysmal Subarachnoid Hemorrhage Is Predictive of Vasospasm
Authors: Bacigaluppi Susanna , Ivaldi Federico , Bragazzi Nicola L. , Benvenuto Federica , Gallo Fabio , D'Andrea Alessandro , Severi Paolo , Uccelli Antonio , Zona Gianluigi 
Published: December 2020

Objective: Vasospasm is a severe complication in patients with aneurysmal subarachnoid hemorrhage (aSAH) and cannot be reliably predicted. Its pathophysiology remains elusive with the current body of evidence suggesting inflammation as one of the main driving forces. We here aimed to analyze circulating immune cell subsets over time in patients with aSAH with or without vasospasm.Methods: We performed a prospective observational study recruiting patients with spontaneous aSAH. Peripheral blood withdrawn at pre-specified time-points after aSAH, day 0, days 3–4, 6–8, 10–11, 13–15, and 18–21. Flow cytometry analysis, cell blood counts, and laboratory and diagnostic parameters were performed. Patients were monitored by transcranial Doppler for vasospasm as well as by advanced imaging and divided into a group with (VS) and without vasospasm VS (NVS).Results: We included 42 patients for study analysis, 21 VS and 21 NVS. An early significant increase at day 0 in platelet, leukocyte, neutrophil, lymphocyte, NK lymphocyte, monocyte, and CD 14++ CD16− DR+ monocyte counts was found in patients with later ensuing vasospasm. The early differences in platelets, leukocytes, lymphocytes, and NK lymphocytes remained significant on multivariate analysis.Conclusions: An early increase of immune cellular subsets in aSAH may contribute to predict VS.
Evaluation of White Matter Integrity Utilizing the DELPHI (TMS-EEG) System
Authors: Levy-Lamdan Ofri , Zifman Noa , Sasson Efrat , Efrati Shai , Hack Dallas C. , Tanne David , Dolev Iftach , Fogel Hilla 
Published: December 2020

ObjectiveThe aim of this study was to evaluate brain white matter (WM) fibers connectivity damage in stroke and traumatic brain injury (TBI) subjects by direct electrophysiological imaging (DELPHI) that analyzes transcranial magnetic stimulation (TMS)-evoked potentials (TEPs).MethodsThe study included 123 participants, out of which 53 subjects with WM-related pathologies (39 stroke, 14 TBI) and 70 healthy age-related controls. All subjects underwent DELPHI brain network evaluations of TMS-electroencephalogram (EEG)-evoked potentials and diffusion tensor imaging (DTI) scans for quantification of WM microstructure fractional anisotropy (FA).ResultsDELPHI output measures show a significant difference between the healthy and stroke/TBI groups. A multidimensional approach was able to classify healthy from unhealthy with a balanced accuracy of 0.81 ± 0.02 and area under the curve (AUC) of 0.88 ± 0.01. Moreover, a multivariant regression model of DELPHI output measures achieved prediction of WM microstructure changes measured by FA with the highest correlations observed for fibers proximal to the stimulation area, such as frontal corpus callosum (r = 0.7 ± 0.02), anterior internal capsule (r = 0.7 ± 0.02), and fronto-occipital fasciculus (r = 0.65 ± 0.03).ConclusionThese results indicate that features of TMS-evoked response are correlated to WM microstructure changes observed in pathological conditions, such as stroke and TBI, and that a multidimensional approach combining these features in supervised learning methods serves as a strong indicator for abnormalities and changes in WM integrity.
Intestinal Epithelial Cell-Derived Extracellular Vesicles Modulate Hepatic Injury via the Gut-Liver Axis During Acute Alcohol Injury
Authors: Lamas-Paz Arantza , Morán Laura , Peng Jin , Salinas Beatriz , López-Alcántara Nuria , Sydor Svenja , Vilchez-Vargas Ramiro , Asensio Iris , Hao Fengjie , Zheng Kang , Martín-Adrados Beatriz , Moreno Laura , Cogolludo Angel , Gómez del Moral Manuel , Bechmann Lars , Martínez-Naves Eduardo , Vaquero Javier , Bañares Rafael , Nevzorova Yulia A. , Cubero Francisco Javier 
Published: December 2020

Binge drinking, i.e., heavy episodic drinking in a short time, has recently become an alarming societal problem with negative health impact. However, the harmful effects of acute alcohol injury in the gut-liver axis remain elusive. Hence, we focused on the physiological and pathological changes and the underlying mechanisms of experimental binge drinking in the context of the gut-liver axis. Eight-week-old mice with a C57BL/6 background received a single dose (p.o.) of ethanol (EtOH) [6 g/kg b.w.] as a preclinical model of acute alcohol injury. Controls received a single dose of PBS. Mice were sacrificed 8 h later. In parallel, HepaRGs and Caco-2 cells, human cell lines of differentiated hepatocytes and intestinal epithelial cells intestinal epithelial cells (IECs), respectively, were challenged in the presence or absence of EtOH [0–100 mM]. Extracellular vesicles (EVs) isolated by ultracentrifugation from culture media of IECs were added to hepatocyte cell cultures. Increased intestinal permeability, loss of zonula occludens-1 (ZO-1) and MUCIN-2 expression, and alterations in microbiota—increased Lactobacillus and decreased Lachnospiraceae species—were found in the large intestine of mice exposed to EtOH. Increased TUNEL-positive cells, infiltration of CD11b-positive immune cells, pro-inflammatory cytokines (e.g., tlr4, tnf, il1β), and markers of lipid accumulation (Oil Red O, srbep1) were evident in livers of mice exposed to EtOH, particularly in females. In vitro experiments indicated that EVs released by IECs in response to ethanol exerted a deleterious effect on hepatocyte viability and lipid accumulation. Overall, our data identified a novel mechanism responsible for driving hepatic injury in the gut-liver axis, opening novel avenues for therapy.
Social Embeddedness of Firefighters, Paramedics, Specialized Nurses, Police Officers, and Military Personnel: Systematic Review in Relation to the Risk of Traumatization
Authors: Geuzinge Renate , Visse Merel , Duyndam Joachim , Vermetten Eric 
Published: December 2020

Background:Firefighters, paramedics, specialized nurses working in Intensive Care Units (ICUs), Operating Rooms (OR), and Emergency Rooms (ER), police officers and military personnel are more frequently exposed to potentially traumatic events than the general population; they are considered high-risk professionals. To reduce the risk of traumatization it is of great importance to be embedded in a social environment with supportive relationships.Methods:We performed a systematic review (based on the PRISMA-Guidelines) looking for social connections within the environment in which high-risk professionals are embedded (work, home, community), to obtain evidence on the impact of these connections on the risk of traumatization. Additionally, we aim to identify relevant supportive relationships in the professionals' environments. We identified the relevant scientific literature by searching, without time, and language restriction, five electronic bibliographic databases: MEDLINE, PsycINFO, Sociological Abstracts, CINAHL, and Web of Science. These databases were last searched in January 2019.Results:A qualitative analysis of the 89 eligible (out of 9,047 screened) studies shows that for firefighters, paramedics, and emergency nurses social connections in their work environment are predominantly supportive relationships and may protect them against traumatization. In other occupations (OR-nurses, ICU-nurses, police officers), however, social connections at work are not only a source of support but are also a source of stress. For military personnel study results are inconclusive as to whether their social connections at work or at home support them against traumatization. In so far as connections are supportive, their sources vary greatly from one occupational group to another; they differ between work vs. home as well as within work between peers vs. supervisor.Conclusions:Being embedded in a social environment, i.e., having social connections, is important but not always sufficient to protect high-risk professionals against traumatization. For, while these connections may be the antecedents of supportive relationships, they can also be the antecedents of damaging relationships. Additionally, the sources of supportive relationships differ among groups. This suggests that knowledge of how the social structures of the occupational groups differ may increase our understanding of the impact of social connections and relationships, including socialization, on the risk of traumatization of high-risk professionals.
HUBUNGAN KADAR EKSKRESI IODIUM URINE (EIU) DENGAN KEJADIAN GONDOK PADA ANAK USIA SEKOLAH DI DAERAH ENDEMIS GAKI
Authors: Diniah Bibit Nasrokhatun 
Published: December 2020

Permasalahan yang umumnya terdapat di daerah endemis GAKI adalah kejadian pembesaran kelenjar tiroid (gondok). Gondok merupakan salah satu manifestasi klinis dari kondisi GAKI. Faktor-faktor yang dapat menyebabkan timbulnya gondok tidak hanya keadaan defisiensi iodium saja, akan tetapi keadaan ekses iodium atau kelebihan asupan iodium pada seseorang dapat menyebabkan gondok. Ekses iodium yang terjadi secara terus menerus akan dapat mengganggu proses sintesis hormon tiroid. Penelitian ini bertujuan untuk menganalisis hubungan antara kadar EIU dengan kejadian gondok.
Jenis penelitian adalah observasional analitik dengan desain cross sectional. Sampel merupakan anak usia sekolah (6-12) sebanyak 51 anak dengan teknik penentuan sampel purposive sampling. Pengukuran kadar EIU dengan metode laboratorium Ammonium Persulphate Digestion Method dan pengukuran kejadian gondok menggunakan metode palpasi.
Sebanyak 51 anak (100%) memiliki kadar EIU diatas batas kecukupan (120 µg/dL);min 152 µg/dL; maks 284 µg/dL; mean 251,76 µg/dL, sebanyak 39,2% responden menderita gondok, meliputi grade 1 sebesar 37,2% dan grade 2 sebesar 2%. Tidak terdapat hubungan yang signifikan antara Kadar Ekskresi Iodium Urine (EIU) dengan kejadian gondok (p=0,743)
PENGARUH TEKNIK SHOOTING INSTEP DRIVE TERHADAP HASIL SHOOTING PADA TIM SEPAKBOLA U-16 SMAN 1 JELIMPO KABUPATEN LANDAK.
Authors: Anugrarista Ella Ella , Man Aris 
Published: December 2020

Tujuan penelitian ini Untuk mengetahui pengaruh Teknik Shooting Instep Drive Terhadap Hasil Shooting Pada Tim Sepakbola U-16 SMAN 1 Jelimpo Kabupaten Landak. Penelitian ini merupakan penelitian dengan metode eksperimen one-group pretest-posttest design. Sampel sebanyak 22 pemain dengan mengunakan teknik sampling jenuh. Teknik analisis data yang digunakan dalam penelitian ini adalah dengan mengunakan uji yang merupakan untuk mencari perbedaan masing-masing kelompok. Hasil penelitian ini menunjukan bahwa: Pengaruh Teknik Shooting Instep Drive Terhadap Hasil Shooting Pada Tim Sepakbola U-16 SMAN 1 Jelimpo Kabupaten Landak, ditunjukan dengan hasil uji hipotesis dapat dilihat bahwa 4,939 > 1,717 dan nilai signifikansi 0,115 > 0,05 maka hipotesis dapat dinyatakan di terima, dengan selisih rata-rata pret test dan pos test adalah 4,954 maka dari selisih rata-rata tersebut dapat diketahui kenaikan persentase sebesar 54,22%.
WORKSHOP EFEKTIVITAS PEMBELAJARAN DARING PADA MASA PANDEMI COVID 19 DI PRODI IKOR
Authors: Hamidi Ahmad 
Published: December 2020

Tujuan penelitian ini adalah mengidentifikasi dan mengumpulkan informasi tentang implementasi pembelajaran daring(on line) pada mata kuliah golf di prodi ikor akibat dari adanya pandemi COVID-19. Penelitian ini menggunakan metode induktif eksploratif dengan pendekatan kualitatif . Responden penelitian ini sebanyak 27 orang yang terdiri dari 18 mahasiswa laki-laki dan 8 orang mahasiswa peempuan.. Instrumen yang digunakan adalah dengan teknik Wawancara; dilakukan terstruktur dengan pertanyaan yang disusun dan dikaitkan serta dikembangkan dengan literatur terkait. Hasil dari penelitian ini menunjukkan kurang efektif nya pembelajaran online dalam perkuliahan golf dikarenakan faktor kurangnya sarana dan prasarana serta ketidaksiapan edukasi teknologi bagi mahasiswa
Perlindungan Hukum Terhadap Anak Pelaku Tindak Pidana Dalam Proses Penyidikan di Kepolisian Daerah Bengkulu (Ditinjau Dari Undang-Undang Nomor 11 Tahun 2012 Tentang Sistem Peradilan Pidana Anak)
Authors: Karyawan Arsi 
Published: December 2020

Hak-hak anak seringkali tidak dilindungi pada setiap tingkat pemeriksaan, mulai dari proses penyidikan hingga proses di pengadilan. Polisi sebagai gerbang terdepan proses penyaringan perkara pidana yang melaksanakan proses penyidikan terhadap pelaku tindak pidana dalam hal ini merupakan instansi pertama dalam sistem peradilan pidana. Kasus pidana yang melibatkan anak dibawah umur di Kepolisian Daerah Bengkulu sejak terhitung dari tahun 2013 sampai dengan tahun 2015 mengalami peningkatan yang signifikan. Dari permasalahan tersebut peneliti tertarik melakukan penelitian tentang perlindungan hukum terhadap anak pelaku tindakan pidana dengan penelitian secara deskriptif. Hasil penelitian didapat bahwa bentuk perlindungan hukum dalam proses penyidikan terhadap anak pelaku tindak pidana yang dilakukan Kepolisian Daerah Bengkulu yaitu unit perlindungan perempuan dan anak (PPA), belum sesuai dengan ketentuan perundang-undangan yaitu undang-undang no 11 tahun 2012. Proses Penyidikan terhadap anak pelaku tindak pidana di Kepolisian Daerah Bengkulu, berdasarakan hasil penelitian yang dilakukan oleh penulis sebenarnya sudah berjalan sebagaimana yang diatur dalam undang-undang namun sayang nya pelaksanaan ini tidak didukung oleh fasilitas yang memadai di Kepolisian Daerah Bengkulu, sehingga hak-hak yang seharusnya diperoleh oleh anak tidak terpenuhi sepenuhnya. Kata Kunci : Perlindungan hukum, anak pelaku tindakan pidana
LA GRATUIDAD DE LOS DERECHOS PRESTACIONALES COMO DERECHOS HUMANOS. UNA PROPUESTA PARA SU PONDERACIÓN Y OTORGAMIENTO
Authors: Santillán Pérez Eduardo , Rosales Carlos Manuel 
Published: December 2020

El reconocimiento y la implementación de los Derechos Humanos ha generado que su cumplimiento sea en algunos casos a costa del erario. Este artículo analizará si los derechos prestacionales solicitados como Derechos Humanos deben ser otorgados sin condiciones, o si, al contrario, debe existir un mecanismo para que no haya abuso en su exigibilidad y justiciabilidad.
LA POLÍTICA MIGRATORIA MEXICANA FRENTE AL RETO CENTROAMERICANO 2018-2019
Authors: Ramos García José María , Barrachina Lisón Carlos , Ramos Valencia Jimmy Enmmanuel 
Published: December 2020

El objetivo general de este documento de trabajo es analizar la política migratoria del Estado mexicano en la frontera sur de México y en su relación con el gobierno de los Estados Unidos a partir de la nueva administración federal mexicana en diciembre de 2018. El argumento a contrastar plantea que la nueva política migratoria mexicana se asocia más a un enfoque de seguridad fronteriza, que a una política de seguridad humana.Los temas generales que se desarrollan para fundamentar el objetivo general son los siguientes: 1) El contexto de la inseguridad multidimensional en la frontera sur, se analiza la problemática multidimensional en la frontera sur mexicana; 2) Programa Frontera Sur: políticas y limitaciones, se examinan algunos rasgosde programas previos hacia la frontera sur. 3) Antecedentes y contexto de la nueva política migratoria mexicana, 2014-2018, se analiza a manera de antecedentes el Programa Especial de Migración y los objetivos de la nueva política migratoria del Estado mexicano: 2018-2019, 4) El Plan para Desarrollo Integral de Centroamérica, contexto y opciones de política pública, se analiza la segunda prioridad de la agenda migratoria mexicana; 5) La política de seguridad fronteriza en la nueva administración federal y la relación con los Estados Unidos, 2019, se examinan los rasgos principales de la actual política de seguridad fronteriza mexicana y de Estados Unidos, 6) La redefinición de la relación con los Estados Unidos en la política migratoria, se destacan los rasgos principales del Acuerdo migratorio binacional para controlar la migración irregular centroamericana, 7) Algunos impactos de la nueva agenda de cooperación migratoria de México con los Estados Unidos, se examinan los principales impactos de la implementación de la política migratoria mexicana actual en el marco de su relación con los Estados Unidos.