bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography
Authors: Veenstra Colin , Kruitwagen Saskia , Groener Dafne , Petersen Wilma , Steenbergen Wiendelt , Bosschaart Nienke 
Published: October 2019

AbstractThe non-invasive quantification of total haemoglobin concentrations [tHb] is highly desired for the assessment of haematologic disorders in vulnerable patient groups, but invasive blood sampling is still the gold standard in current clinical practice. This work demonstrates the potential of visible-light spectroscopic optical coherence tomography (sOCT) for quantifying the [tHb] in human whole blood. To accurately quantify the [tHb] from the substantial optical attenuation by blood in the visible wavelength range, we used a combination of zero-delay acquisition and focus tracking that ensures optimal system sensitivity at any depth inside the sample. Subsequently, we developed an analysis model to adequately correct for the high scattering contribution by red blood cells to the sOCT signal. We validate our method and compare it to conventional sOCT (without focus tracking and zero-delay acquisition) through ex-vivo measurements on flowing human whole blood, with [tHb] values in the clinical range of 7–23 g/dL. For our method with optimized sensitivity, the measured and expected values correlate well (Pearson correlation coefficient = 0.89, p < 0.01), with a precision of 3.8 g/dL. This is a considerable improvement compared to conventional sOCT (Pearson correlation coefficient = 0.59, p = 0.16; precision of 9.1 g/dL).
Expression of FGD3 gene as prognostic factor in young breast cancer patients
Authors: Renda Irene , Bianchi Simonetta , Vezzosi Vania , Nori Jacopo , Vanzi Ermanno , Tavella Ketty , Susini Tommaso 
Published: October 2019

AbstractThe FGD3 gene works as a cell migration inhibitor and seems to be a promising indicator of outcome in some human cancers including breast. In this study, we analysed for the first time the prognostic role of FGD3 in young breast cancer patients. We studied the relationship between traditional prognostic factors, FGD3 expression and outcome in ≤40 years breast cancer patients. We found that lower FGD3 expression decreased the probability of disease-free survival (p = 0.042) and overall survival (p = 0.007). In a multivariate analysis for overall survival AJCC stage (p = 0.005) and FGD3 expression (p = 0.03) resulted independent prognostic factors. Low FGD3 expression increased the risk of death from disease (HR 5.73, p = 0.03). Moreover, low FGD3 expression was associated with more widespread lymph node involvement (p = 0.04) and a lower FGD3 staining intensity was found in positive-lymph-node patients vs negative (p = 0.003) and in patients with ≥10 involved lymph nodes vs <10 (p = 0.05). Our results suggest FGD3 to be a significant independent prognostic factor in young breast cancer patients in terms of disease-free survival and overall survival. A lower expression increased the risk of recurrence and death from disease and was associated with widespread lymph node metastases.
Sea Surface Height Estimation with Multi-GNSS and Wavelet De-noising
Authors: Chen Fade , Liu Lilong , Guo Fei 
Published: October 2019

AbstractThis paper presents a new sea surface height (SSH) estimation using GNSS reflectometry (GNSS-R). It is a cost-effective remote sensing technique and owns long-term stability besides high temporal and spatial resolution. Initial in-situ SSH estimates are first produced by using the SNR data of BDS (L1, L5, L7), GPS (L1, L2, L5), and GLONASS (L1, L2), of MAYG station, which is located in Mayotte, France near the Indian Ocean. The results of observation data over a period of seven days showed that the root mean square error (RMSE) of SSH estimation is about 32 cm and the correlation coefficient is about 0.83. The tidal waveform is reconstructed based on the initial SSH estimates by utilizing the wavelet de-noising technique. By comparing the tide gauge measurements with the reconstructed tidal waveform at SSH estimation instants, the SSH estimation errors can be obtained. The results demonstrate that the correlation coefficient and RMSE of the wavelet de-noising based SSH estimation is 0.95 and 19 cm, respectively. Compared with the initial estimation results, the correlation coefficient is improved by about 14.5%, while the RMSE is reduced by 40.6%.
A cost-effective and environmentally sustainable process for phycoremediation of oil field formation water for its safe disposal and reuse
Authors: Das Bhaskar , Deka Suresh 
Published: October 2019

AbstractHigh volumes of formation water comprising of complex mixture of hydrocarbons is generated during crude oil exploration. Owing to ecotoxicological concerns, the discharge of the formation water without remediation of hydrocarbonaceous pollutants is not permitted. Keeping this into mind, we carried out phycoremediation of hydrocarbons in formation water so that it can be safely discharged or re-used. For this, a native algal species was isolated from formation water followed by its morphological and 18S ribosomal RNA based identification confirming the algal isolate to beChlorella vulgarisBS1 (NCBI GenBank Accession No. MH732950). The algal isolate exhibited high biomass productivity of 1.76 gm L−1d−1(specific growth rate: 0.21 d−1, initial inoculum: 1500 mg L−1) along with remediation of 98.63% petroleum hydrocarbons present in formation water within 14 days of incubation indicating an efficient hydrocarbon remediation process. Concomitantly, the hydrocarbon remediation process resulted in reduction of 75% Chemical Oxygen Demand (COD) load and complete removal of sulfate from formation water making it suitable for safe disposal or reuse as oil well injection water respectively. The present process overcomes the bottlenecks of external growth nutrient addition or dilution associated with conventional biological treatment resulting in a practically applicable and cost-effective technology for remediation of oil field formation water.
Using SpO2 Recovery Index after a 6-Minute Walk Test to Predict Respiratory-Related Events in Hospitalized Patients with Interstitial Pneumonia
Authors: Sakai Yasunari , Yamamoto Shuhei , Hoshina Miho , Kawachi Shohei , Ichiyama Takashi , Hanaoka Masayuki 
Published: October 2019

AbstractAlthough the prognostic factors of interstitial pneumonia (IP) patients have been reported, IP has poor prognosis. Hospitalized patients with IP have severely impaired pulmonary diffusion capacity and prominent desaturation. We hypothesized that determining oxygen saturation recovery (SpO2 recovery index) after the 6-minute walk test (6MWT) can provide additional prognostic information regarding rehospitalization for respiratory-related events. We evaluated 73 IP patients at our hospital for demographic characteristics, pulmonary function tests and 6MWT. The Kaplan–Meier method was used to estimate rehospitalisation for respiratory-related events using SpO2 recovery index. Cox regression analysis revealed a relationship between SpO2 recovery index and rehospitalisation. The optimum cutoff value of SpO2 recovery index was 4% (sensitivity, 71.4%; specificity, 79.2%). SpO2 recovery index was most closely related to pulmonary diffusion capacity (r = 0.684, P < 0.001). In a multivariable model, it was the strongest independent predictor of rehospitalisation for respiratory-related events (hazard ratio, 0.3; 95% confidence interval, 0.10–0.90; P = 0.032). In this study, we estimated pulmonary diffusion capacity using SpO2 recovery index values obtained from 6MWT. A SpO2 recovery index of <4% can be useful in predicting rehospitalisation for respiratory-related events.
Calibrated interdental brushing for the prevention of periodontal pathogens infection in young adults - a randomized controlled clinical trial
Authors: Bourgeois Denis , Bravo Manuel , Llodra Juan-Carlos , Inquimbert Camille , Viennot Stéphane , Dussart Claude , Carrouel Florence 
Published: October 2019

AbstractPeriodontal disease is clearly correlated with systemic disease. The presence of periodontal pathogens in interdental spaces in young, healthy adults is a strong indicator of the need to introduce daily interdental prophylaxis. Twenty-five subjects (aged 18–35 years), diagnosticated clinically as periodontally healthy, were enrolled in this study. One hundred interdental sites were included. Among these sites, 50 “test” sites were cleaned daily with calibrated interdental brushes (IDBs), whereas the other 50 sites were not cleaned and considered “controls”. The interdental biofilm at these interdental sites was collected at the beginning of the study (basal) and at 1 week, 2 weeks, 3 weeks, 4 weeks, and 3 months. Real-time polymerase chain reaction (PCR) methodology was used to quantify (i) 19 periodontal bacteria, including Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, and (ii) total bacteria. In the test sites, the quantity of total bacteria decreased over time with the use of IDBs. The bacteria from the red and orange Socransky complexes, which are associated with periodontal disease, significantly decreased in the test sites but not in the control sites. Bacteria from the yellow, and purple Socransky complexes, which are associated with periodontal health, increased significantly in both groups whereas bacteria from the blue Socransky complex increased significantly only in the test sites. Furthermore, at basal, 66% of test sites and 68% of control sites bled during interdental brushing. These percentages decreased by 85% in 3 months for the test sites and by 27% in the control sites. In conclusion, the daily use of calibrated IDBs can reduce periodontal pathogens, reestablish symbiotic microbiota and, decrease interdental inflammation in interdental sites of healthy young adults.
Comparing Traditional and Tablet-Based Intervention for Children With Speech Sound Disorders: A Randomized Controlled Trial
Authors: Jesus Luis M. T. , Martinez Joana , Santos Joaquim , Hall Andreia , Joffe Victoria 
Published: October 2019

Purpose
This article reports on the effectiveness of a novel tablet-based approach to phonological intervention and compares it to a traditional tabletop approach, targeting children with phonologically based speech sound disorders (SSD).

Method
Twenty-two Portuguese children with phonologically based SSD were randomly assigned to 1 of 2 interventions, tabletop or tablet (11 children in each group), and received intervention based on the same activities, with the only difference being the delivery. All children were treated by the same speech-language pathologist over 2 blocks of 6 weekly sessions, for 12 sessions of intervention. Participants were assessed at 3 time points: baseline; pre-intervention, after a 3-month waiting period; and post-intervention. Outcome measures included percentage of consonants correct, percentage of vowels correct, and percentage of phonemes correct. A generalization of target sounds was also explored.

Results
Both tabletop and tablet-based interventions were effective in improving percentage of consonants correct and percentage of phonemes correct scores, with an intervention effect only evident for percentage of vowels correct in the tablet group. Change scores across both interventions were significantly greater after the intervention, compared to baseline, indicating that the change was due to the intervention. High levels of generalization (60% and above for the majority of participants) were obtained across both tabletop and tablet groups.

Conclusions
The software proved to be as effective as a traditional tabletop approach in treating children with phonologically based SSD. These findings provide new evidence regarding the use of digital materials in improving speech in children with SSD.

Supplemental Material

https://doi.org/10.23641/asha.9989816
From scientific evidence to media and policy: Wine – part of a balanced diet or a health risk?
Authors: Fradera U. , Stein-Hammer C. 
Published: October 2019

Recently, some studies [1, 2] and media reports alerted scientists, health and wine professionals alike. The health benefits of moderate wine consumption were questioned with headlines such as “One drink a day can shorten life” and “Moderate drinking guidelines are too loose, study says”. One publication [2] asserted that there is no safe level of consumption and that the adverse health effects associated with the consumption of alcoholic beverages, including wine, outweigh any beneficial effects; this kind of media attention not only contributed to a considerable uncertainty among moderate wine drinkers but also among physicians advising their patients. What about the existing body of evidence and the research results during the last two and half decades that have established the J-curve? It describes the association between the consumption of alcoholic beverages and the total mortality where light to moderate drinkers are at a lower risk of death from all causes than either abstainers or heavy drinkers. However, excessive drinking is always associated with an increased risk of death and various health risks. Are these previous scientific data no longer valid? Is cutting down or even eliminating wine consumption a public health goal? A detailed scientific analysis of these publications will be provided and discussed whether the drinking guidelines worldwide should be adjusted. The risk of moderate wine drinkers within the scope of other risk factors will be examined.
Efficacy of endoscopic treatments for acute esophageal variceal bleeding in cirrhotic patients: systematic review and meta-analysis
Authors: Onofrio Fernanda de Quadros , Pereira-Lima Julio Carlos , Valença Felipe Marquezi , Azeredo-da-Silva André Luis Ferreira , Tetelbom Stein Airton 
Published: October 2019

Abstract
Background and aim Guidelines recommend use of ligation and vasoactive drugs as first-line therapy and as grade A evidence for acute variceal bleeding (AVB), although Western studies about this issue are lacking.
Methods We performed a systematic review and meta-analysis of randomized controlled trials (RCT) to evaluate the efficacy of endoscopic treatments for AVB in patients with cirrhosis. Trials that included patients with hepatocellular carcinoma, use of portocaval shunts or esophageal resection, balloon tamponade as first bleeding control measure, or that received placebo or elective treatment in one study arm were excluded.
Results A total of 8382 publications were searched, of which 36 RCTs with 3593 patients were included. Ligation was associated with a significant improvement in bleeding control (relative risk [RR] 1.08; 95 % confidence interval [CI] 1.02 – 1.15) when compared to sclerotherapy. Sclerotherapy combined with vasoactive drugs showed higher efficacy in active bleeding control compared to sclerotherapy alone (RR 1.17; 95 % CI 1.10 – 1.25). The combination of ligation and vasoactive drugs was not superior to ligation alone in terms of overall rebleeding (RR 2.21; 95 %CI 0.55 – 8.92) and in-hospital mortality (RR 1.97; 95 %CI 0.78 – 4.97). Other treatments did not generate meta-analysis.
Conclusions This study showed that ligation is superior to sclerotherapy, although with moderate heterogeneity. The combination of sclerotherapy and vasoactive drugs was more effective than sclerotherapy alone. Although current guidelines recommend combined use of ligation with vasoactive drugs in treatment of esophageal variceal bleeding, this study failed to demonstrate the superiority of this combined treatment.
Endoscopic ultrasound-guided gallbladder drainage, transpapillary drainage, or percutaneous drainage in high risk acute cholecystitis patients: a systematic review and comparative meta-analysis
Authors: Mohan Babu P. , Khan Shahab R. , Trakroo Sushruth , Ponnada Suresh , Jayaraj Mahendran , Asokkumar Ravishankar , Adler Douglas G. 
Published: October 2019

Abstract
Background Endoscopic transpapillary gallbladder drainage (ETGBD) and endoscopic ultrasound-guided gallbladder drainage (EUSGBD) are alternatives to percutaneous gallbladder drainage (PCGBD) for patients with acute cholecystitis who are unfit for surgery. Data comparing these modalities are limited and have reported conflicting results.
Methods We searched multiple databases from inception to May 2019 to identify studies that reported on ETGBD, EUSGBD, and PCGBD in the management of acute cholecystitis in patients with a high surgical risk. Aims were to compare the pooled rates of technical success, clinical success, adverse events, and disease recurrence.
Results 1223 patients (22 studies), 557 patients (14 studies), and 13 351 patients (46 studies) were treated by ETGBD, EUSGBD, and PCGBD, respectively. The pooled technical and clinical successes were: ETGBD 83 % (95 % confidence interval [CI] 80.1 – 85.5, I
2 = 29) and 88.1 % (95 %CI 83.6 – 91.4, I
2 = 50), respectively; EUSGBD 95.3 % (95 %CI 92.8 – 96.9, I
2 = 0) and 96.7 % (95 %CI 94.0 – 98.2, I
2 = 0), respectively; and PCGBD 98.7 % (95 %CI 98.0 – 99.1, I
2 = 0) and 89.3 % (95 %CI 86.6 – 91.5, I
2 = 84), respectively. Clinical success with EUSGBD was significantly superior to the other approaches. All complications were comparable between the groups. Pancreatitis occurred with ETGBD in 5.1 % (95 %CI 3.5 – 7.3), whereas bleeding and perforation occurred with EUSGBD in 4.3 % (95 %CI 2.7 – 6.8) and 3.7 % (95 %CI 2.3 – 6.0), respectively. Stent migration occurred with PCGBD in 7.4 % (95 %CI 5.5 – 10.0).
Conclusion EUSGBD demonstrated better clinical success than ETGBD and PCGBD in the management of acute cholecystitis patients at high surgical risk.
Postoperative Upper Extremity Function in Implant and Autologous Breast Reconstruction
Authors: Alba Brandon , Schultz Benjamin , Qin Lei Alexander , Cohen Danielle , DelMauro Matthew , Ahn Soyouen , Kasabian Armen K. , Perry Adam D. , Tanna Neil 
Published: October 2019

Abstract
Background After mastectomy and breast reconstruction, many patients experience upper extremity complications, such as pain, restriction in motion, and lymphedema. Despite an aesthetically satisfactory outcome, these occurrences can diminish a patient's postoperative quality of life. Several studies have investigated the causes and incidence of these complications. However, there is currently a paucity of data comparing postoperative upper extremity function according to reconstruction technique.
Methods A review was performed of patients enrolled in a physical therapy (PT) program after mastectomy and immediate breast reconstruction. PT initial encounter evaluations were used to gather data on patients' postoperative upper extremity function. Hospital records were used to gather surgical and demographic data. For each patient, data were collected for each upper extremity that was ipsilateral to a reconstructed breast. Data were then compared between patients who underwent implant-based versus autologous deep inferior epigastric perforator flap reconstruction.
Results A total of 72 patients were identified, including 39 autologous and 33 implant-based reconstruction cases. Proportions of patients who underwent sentinel lymph node biopsies and axillary lymph node dissections were similar between the two groups. The autologous-based reconstruction patients had significantly higher arm pain at rest (p = 0.004) and with activity (p = 0.031) compared with implant patients. Shoulder range of motion and manual muscle test results were similar between groups, with the exception of elbow flexion, which was weaker in implant patients (p = 0.030). Implant patients were also more likely to report “severe difficulty” or “inability” to perform activities of daily living (p = 0.022). Edema/swelling, axillary cording, and lymphedema girth measurements were similar between the two groups.
Conclusion Different techniques of breast reconstruction can result in different postoperative upper extremity complications. These data show specific areas where postoperative care and PT can be customized according to reconstruction type. Investigation is currently underway to determine the effect of PT on upper extremity function in these patients.
Single-Stage Transpedicular Approach for Circumferential Arthrodesis in Traumatic Lumbar Vertebral Body Burst Fractures
Authors: Garg Mayank , Kumar Amandeep , Singh Pankaj Kumar , Agrawal Deepak , Satyarthee Guru Dutt , Gupta Deepak , Gurjar Hitesh Kumar , Mishra Shashwat , Chandra Poodipedi S. , Kale Shashank S. 
Published: October 2019

Abstract
Background Traumatic vertebral burst fractures can be surgically approached via different approaches (anterior/posterior, or combined). Posterior transpedicular approach (PTA) is a posterior approach that has the advantage of achieving circumferential arthrodesis via single posterior-only approach. The purpose of this study was to analyze our experience with PTA in management of traumatic lumbar burst fractures (TLBFs).
Methods All consecutive patients with TLBFs managed with PTA over 3 years’ duration were included in this retrospective study. Correction of kyphotic deformity and change in neurologic status were analyzed to assess outcome. Cobb’s angle and American Spinal Injury Association (ASIA) grade were used for this purpose.
Results There were 12 males and 8 females. Five patients had complete (ASIA-A) while 12 had incomplete injury. The mean preoperative Cobb’s angle was 14.23 degrees that improved to–3.21 degrees postoperatively (mean kyphosis correction: 17.44 degrees). None of the patients developed iatrogenic nerve root injury. There was no perioperative mortality. The mean Cobb’s angle was 1.45 degrees at 36 months’ follow-up. Four patients developed cage subsidence but none required revision surgery. Postoperatively, 13 (65%) patients showed neurologic improvement and none deteriorated. The average ASIA score improved from 2.82 to 4.23. A fusion rate of 96% was observed at last follow-up.
Conclusion The advantages of PTA including sense of familiarity with posterior approach among spine surgeons, lesser approach-related morbidity, and results comparable to anterior/combined approaches, make the PTA an attractive option for managing TLBFs. Although technically difficult, it can be successfully used for circumferential arthrodesis in the lumbar region without sacrificing nerve roots.
Craniovertebral Junction Arachnoiditis: An Unusual Sequelae to Tuberculous Meningitis
Authors: Pruthi Nupur , Vora Tarang Kamalkishore , Shukla Dhaval P. 
Published: October 2019

Abstract
Adhesive arachnoiditis at the craniovertebral junction should be suspected in patients with a history of meningitis having delayed onset gradually progressive tetra paresis. Patients can present after an asymptomatic interval of 2 to 20 years. Cardiac gated cine magnetic resonance imaging is useful for its diagnosis. Posterior fossa decompression with upper cervical laminectomy and adhesiolysis appears to be a reasonable treatment for the same. We illustrate two patients who presented to us with gradually progressive spastic tetra paresis; both had prior history of cured tuberculous meningitis.