bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-Stage Feature Selection (MSFS) Algorithm for UWB-Based Early Breast Cancer Size Prediction
Authors: Vijayasarveswari V. , Andrew A.M. , Jusoh M. , Sabapathy T. , Raof R.A.A. , Yasin M.N.M. , Ahmad R.B. , Khatun S. 
Published: February 2020

AbstractBreast cancer is the most common cancer among women and it is one of the main causes of death for women worldwide. To attain an optimum medical treatment for breast cancer, an early breast cancer detection is crucial. This paper proposes a multistage feature selection method that extracts statistically significant features for breast cancer size detection using proposed data normalization techniques. Ultra-wideband (UWB) signals, controlled using microcontroller are transmitted via an antenna from one end of the breast phantom and are received on the other end. These ultra-wideband analogue signals are represented in both time and frequency domain. The preprocessed digital data is passed to the proposed multi-stage feature selection algorithm. This algorithm has four selection stages. It comprises of data normalization methods, feature extraction, data dimensional reduction and feature fusion. The output data is fused together to form the proposed datasets, namely, 8-HybridFeature, 9-HybridFeature and 10-HybridFeature datasets. The classification performance of these datasets is tested using the Support Vector Machine, Probabilistic Neural Network and Naïve Bayes classifiers for breast cancer size classification. The research findings indicate that the 8-HybridFeature dataset performs better in comparison to the other two datasets. For the 8-HybridFeature dataset, the Naïve Bayes classifier (91.98%) outperformed the Support Vector Machine (90.44%) and Probabilistic Neural Network (80.05%) classifiers in terms of classification accuracy. The finalized method is tested and visualized in the MATLAB based 2D and 3D environment.
A genome-wide case-only test for the detection of digenic inheritance in human exomes
Authors: Kerner Gaspard , Bouaziz Matthieu , Cobat Aurélie , Bigio Benedetta , Timberlake Andrew T , Bustamante Jacinta , Lifton Richard P , Casanova Jean-Laurent , Abel Laurent 
Published: February 2020

AbstractWhole-exome sequencing (WES) has facilitated the discovery of genetic lesions underlying monogenic disorders. Incomplete penetrance and variable expressivity suggest a contribution of additional genetic lesions to clinical manifestations and outcome. Some monogenic disorders may therefore actually be digenic. However, only a few digenic disorders have been reported, all discovered by candidate gene approaches applied to at least one locus. We propose here a novel two-locus genome-wide test for detecting digenic inheritance in WES data. This approach uses the gene as the unit of analysis and tests all pairs of genes to detect pairwise gene x gene interactions underlying disease. It is a case-only method, which has several advantages over classic case-control tests, in particular by avoiding recruitment and bias of controls. Our simulation studies based on real WES data identified two major sources of type I error inflation in this case-only test: linkage disequilibrium and population stratification. Both were corrected by specific procedures. Moreover, our case-only approach is more powerful than the corresponding case-control test for detecting digenic interactions in various population stratification scenarios. Finally, we validated our unbiased, genome-wide approach by successfully identifying a previously reported digenic lesion in patients with craniosynostosis. Our case-only test is a powerful and timely tool for detecting digenic inheritance in WES data from patients.Significance statementDespite a growing number of reports of rare disorders not fully explained by monogenic lesions, digenic inheritance has been reported for only 54 diseases to date. The very few existing methods for detecting gene x gene interactions from next-generation sequencing data were generally studied in rare-variant association studies with limited simulation analyses for short genomic regions, under a case-control design. We describe the first case-only approach designed specifically to search for digenic inheritance, which avoids recruitment and bias related to controls. We show, through both extensive simulation studies on real WES datasets and application to a real example of craniosynostosis, that our method is robust and powerful for the genome-wide identification of digenic lesions.
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome
Authors: Duran-Ferrer Martí , Clot Guillem , Nadeu Ferran , Beekman Renée , Baumann Tycho , Nordlund Jessica , Marincevic-Zuniga Yanara , Lönnerholm Gudmar , Rivas-Delgado Alfredo , Martin Silvia , Ordoñez Raquel , Castellano Giancarlo , Kulis Marta , Queirós Ana , Seung-Tae Lee , Wiemels Joseph , Royo Romina , Puiggrós Montserrat , Lu Junyan , Gine Eva , Beà Sílvia , Jares Pedro , Agirre Xabier , Prosper Felipe , López-Otín Carlos , Puente Xosé S. , Oakes Christopher C. , Zenz Thorsten , Delgado Julio , López-Guillermo Armando , Campo Elías , Martin-Subero José Ignacio 
Published: February 2020

AbstractWe report a systematic analysis of the biological and clinical implications of DNA methylation variability in five categories of B-cell tumors derived from B cells spanning the entire maturation spectrum. We used 2056 primary samples including training and validation series and show that 88% of the human DNA methylome is dynamically modulated under normal and neoplastic conditions. B-cell tumors display both epigenetic imprints of their cellular origin andde novo, disease-specific epigenetic alterations that in part are related to differential transcription factor binding. These differential methylation patterns were used by a machine-learning approach to create a diagnostic algorithm that accurately classifies 14 B-cell tumor entities and subtypes with different clinical management. Beyond this, we identified extensive patient-specific epigenetic variability targeting constitutively silenced chromatin regions, a phenomenon we could relate to the proliferative history of normal and neoplastic B cells. We observed that, depending on the maturation stage of the tumor cell of origin, mitotic activity leaves different imprints into the DNA methylome. Subsequently, we constructed a novel DNA methylation-based mitotic clock called epiCMIT (epigenetically-determinedCumulativeMIToses), whose lapse magnitude represents a strong independent prognostic variable within specific B-cell tumor subtypes and is associated with particular driver genetic alterations. Our findings reveal DNA methylation as a holistic tracker of B-cell tumor developmental history, with implications in the differential diagnosis and prediction of the outcome of the patients.
A gatekeeping role of ESR2 to maintain the primordial follicle reserve
Authors: Chakravarthi V. Praveen , Ghosh Subhra , Roby Katherine F. , Wolfe Michael W. , Rumi M. A. Karim 
Published: February 2020

AbstractOver the entire reproductive lifespan in mammals, a fixed number of primordial follicles serve as the source of mature oocytes. Uncontrolled and excessive activation of primordial follicles can lead to depletion of the ovarian reserve. We observed that disruption of ESR2-signaling results in increased activation of primordial follicles inEsr2-null (Esr2-/-) rats. However, follicle assembly was unaffected, and the total number of follicles remained comparable between neonatal wildtype andEsr2-/-ovaries. While the activated follicle counts were increased inEsr2-/-ovary, the number of primordial follicles were markedly decreased. Excessive recruitment of primordial follicles led to premature ovarian senescence inEsr2-/-rats and was associated with reduced levels of serum AMH and estradiol. Disruption of ESR2-signaling through administration of a selective antagonist (PHTPP) increased the number of activated follicles in wildtype rats, whereas a selective agonist (DPN) decreased follicle activation. In contrast, primordial follicle activation was not increased in the absence of ESR1 indicating that the regulation of primordial follicle activation is ESR2-specific. Follicle activation was also increased inEsr2-mutants lacking the DNA-binding domain, suggesting a role for the canonical transcriptional activation function. Both primordial and activated follicles express ESR2 suggesting a direct regulatory role for ESR2 within these follicles. We also detected that loss of ESR2 augmented the activation of AKT, ERK and mTOR pathways. Our results indicate that the lack of ESR2 upregulated both granulosa and oocyte factors, which can facilitate AKT and mTOR activation inEsr2-/-ovaries leading to increased activation of primordial follicles.
Optimization of a multi-constraint two-sided assembly line balancing problem using an improved imperialist competitive algorithm
Authors: Yang Mingshun , Ba Li , Xu Erbao , Li Yan , Liu Yong , Gao Xinqin 
Published: February 2020

Purpose
Assembly is the last step in manufacturing processes. The two-sided assembly line balancing problem (TALBP) is a typical research focus in the field of combinatorial optimization. This paper aims to study a multi-constraint TALBP-I (MC-TALBP-I) that involves positional constraints, zoning constraints and synchronism constraints to make TALBP more in line with real production. For enhancing quality of assembly solution, an improved imperialist competitive algorithm (ICA) is designed for solving the problem.

Design/methodology/approach
A mathematical model for minimizing the weighted sum of the number of mated-stations and stations is established. An improved ICA is designed based on a priority value encoding structure for solving MC-TALBP-I.

Findings
The proposed ICA was tested by several benchmarks involving positional constraints, zoning constraints and synchronism constraints. This algorithm was compared with the late acceptance hill-climbing (LAHC) algorithm in several instances. The results demonstrated that the ICA provides much better performance than the LAHC algorithm.

Practical implications
The best solution obtained by solving MC-TALBP-I is more feasible for determining the real assembly solution than the best solution obtained by solving based TALBP-I only.

Originality/value
A novel ICA based on priority value encoding is proposed in this paper. Initial countries are generated by a heuristic method. An imperialist development strategy is designed to improve the qualities of countries. The effectiveness of the ICA is indicated through a set of benchmarks.
Regulatory focus and learning
Authors: Federman Jessica E. 
Published: February 2020

PurposeThe purpose of this study is to understand how regulatory focus influences informal learning behaviors. A growing body of research indicates that regulatory focus has significant consequences for goal pursuit in the workplace, yet it has not been readily studied or applied to the field of human resource management (Johnsonet al., 2015). This is one of the few studies to examine the relationship between informal learning and regulatory focus theory that can be applied to the training and development field.Design/methodology/approachUsing a qualitative research design, a semi-structured interview was used to increase the comparability of participant responses. Questions were asked in an open-ended manner, allowing for a structured approach for collecting information yet providing flexibility for the sake of gaining more in-depth responses. An interview guideline was used to standardize the questions and ensure similar kinds of information were obtained across participants. A typological analytic approach (Lincoln and Guba, 1985) was used to analyze the data.FindingsIn a sample of 16 working adults, (44% female and 56% male), participants who were identified as having either a promotion- or prevention-focus orientation were interviewed about types of informal learning strategies they used. The results revealed that performance success and failure have differential effects on learning behaviors for prevention and promotion-focus systems. Stress and errors motivate informal learning for the prevention-focus system, whereas positive affect motivates informal learning for the promotion-focus system. Prevention-focus participants articulated greater use of vicarious learning, reflective thinking and feedback-seeking as methods of informal learning. Promotion-focus participants articulated greater use of experimentation methods of informal learning.Originality/valueThis study provides an in-depth understanding of how regulatory focus influences informal learning. Few studies have considered how regulatory focus promotes distinct strategies and inclinations toward using informal learning. Performance success and failure have differential effects on informal learning behaviors for regulatory promotion and prevention systems. This has theoretical and practical implications in consideration of why employees engage in informal learning, and the tactics and strategies they use for learning.
Do intentions ever die? The temporal stability of entrepreneurial intention and link to behavior
Authors: Joensuu-Salo Sanna , Viljamaa Anmari , Varamäki Elina 
Published: February 2020

PurposeThis study aims to contribute to entrepreneurial intention research by examining the theory of planned behavior model in a longitudinal follow-up of the same individuals from a point at which they were studying until six to eight years after graduation and the link between entrepreneurial intention and actual behavior. The objectives of the paper are as follows: to examine the development and temporal stability of entrepreneurial intention and to examine the link between entrepreneurial intention and actual start-up behavior in a longitudinal setting.Design/methodology/approachThe data for this research originate in Finland and consist three data collection waves between years 2008 and 2018. In the second wave, 282 respondents were reached, and in the third wave, 89 respondents were reached. For examining the stability of entrepreneurial intention, latent growth curve modeling was used. In addition, a logistic regression analysis was conducted to examine the link between intention and behavior.FindingsThe results suggest that entrepreneurial intention is a stable construct over time. High and low levels of entrepreneurial intention remain quite stable. Entrepreneurial intention measured during study time significantly explains entrepreneurial behavior both after one to three years (Exp (B) 2,069***) and after six to eight years (Exp (B) 1,830*). Gender and role models are significant factors in predicting entrepreneurial behavior.Originality/valueThis study provides new information on the stability of entrepreneurial intention in a rare longitudinal setting. The study verifies the value of intention measures in predicting entrepreneurial behavior in the long term.
Tapping the potential space-positioning of private labels
Authors: Sharma Veenu , Kedia Bhuvnesh , Yadav Vandana , Mishra Shreya 
Published: February 2020

PurposeThe purpose of this study is to analyze the current scenario of private labels from consumers and retailers’ point of view and provide inputs to the retailers that will help them to increase their profitability. Profitability for retailers is a resultant of efficient inventory management in a limited space. This paper studies consumer’s purchase behavior and facilitates retailers in their decision-making of the dilemma between the appropriate mix of national brands (NBs) and private labels to increase their profitability. Retailers will be able to do cross-merchandising of the categories of the goods having strong associations and will increase the shelf space of the products, which are preferred by customers.Design/methodology/approachMarket basket analysis was done for 1,223 transactions including two or more product categories in each transaction. In total, 564 products were studied and these products were further divided into 23 categories. Lift analysis was done 4 times to find an association between the products of all the categories.FindingsThe results find a strong association between some categories and advocate the placement of these combinations together – one being a NB and another private label.Research limitations/implicationsAnalysis of only a limited set of brands and their product categories for a value retailer cross-merchandising.Originality/valueThe analysis of sales transactions will help retailers in determining the associations between product categories. This association will be helpful in placing their private labelsvis-à-visNBs to do cross-merchandising and allocating judicial space to the product assortment to increase their profitability.
Study on influential role of celebrity credibility on consumer risk perceptions
Authors: Deshbhag Raksha R. , Mohan Bijuna C. 
Published: February 2020

Purpose
The purpose of this study is to determine the influence of celebrity credibility (trustworthiness, attractiveness and expertise) on risk perception and buying intention of Indian fast moving consumer goods (FMCG) consumers.

Design/methodology/approach
The present study adopted the survey method to know the influence of celebrity credibility dimensions on the perceived risk and purchase intentions of Indian FMCG consumers. This study has performed a survey on 250 respondents using the self-administered questionnaire consisting of 18 measurement scales.

Findings
The major findings of this study indicate celebrity trust and celebrity expertise are the most important dimensions of celebrity to influence the risk perceptions of Indian FMCG consumers. The risk perceptions positively influence the purchase intentions of Indian FMCG consumers.

Research limitations/implications
This study was limited to the Indian context, but theoretical contributions in terms of justifying the relationship linking variables, which might affect success, as well as the failure of celebrity endorsements.

Practical implications
The research findings can assist the practitioners in selecting the right celebrity endorser as a spokesperson for promoting Indian FMCG brands based on three dimensions of celebrity credibility (trust, expertise and attractiveness).

Originality/value
The study has proposed and tested the new theoretical model considering the celebrity trust, celebrity expertise and celebrity attractiveness as the affective responses from the buyers of FMCG. Perceived risk is mainly cognitive responses influenced through celebrity credible sources. The study attempted to investigate the impact of both affective and cognitive responses on the purchase intentions of Indian FMCG consumers.
Student drinking: is change possible?
Authors: Lumb Tracy 
Published: February 2020

Purpose
The purpose of this paper is to explore how the NUS (National Union of Students)’ Alcohol Impact programme is attempting to change patterns of student drinking using findings from the 2017 Students and Alcohol national survey conducted by NUS as context.

Design/methodology/approach
The 2017 Students and Alcohol national survey results were gathered via the distribution of the survey using the NUS’ database of NUS extra cardholders. A total of 2,215 responses was collected. Using this information, the author has approached this paper as a case study of NUS’ Alcohol Impact Programme.

Findings
Results from the 2017 Students and Alcohol national survey demonstrated that although there was a misalignment between what students perceived their peers were drinking prior to university and what they were actually reporting drinking, there was the persistence of harmful behaviours reported after consumption of alcohol. Feedback from partnerships involved in the Alcohol Impact programme has shown measurable improvements in areas including the inclusion of non-drinkers and anti-social behaviour.

Originality/value
Rolled out nationally, Alcohol Impact could be used to take positive steps in addressing the harmful consequences of student alcohol consumption.
Ethical dilemmas in studying family consumption
Authors: Khanijou Ratna , Pirani Daniela 
Published: February 2020

Purpose
The purpose of this paper is to explore the types of ethical challenges and dilemmas researchers face when engaging in family consumption research.

Design/methodology/approach
Drawing from the concept of micro-ethics to bridge reflexivity with ethics in practice, the paper provides a reflexive account of the various ethical dilemmas encountered by two family consumption scholars during their fieldwork. Both researchers conducted qualitative research on family meals.

Findings
The paper reveals five types of ethical tensions that can arise when doing research on family consumption. These tensions are addressed as display, positioning, emotional, practical and consent dilemmas, all of which have ethical implications. The findings unpack these dilemmas, showing empirical and reflexive accounts of the researchers as they engage in ethics in practice. Solutions and practical strategies for dealing with these ethical tensions are provided.

Originality/value
Despite the growing interest in interpretive family research, there is less attention on the ethical and emotional challenges researchers face when entering the family consumption scape. As researching families involves entering an intimate area of participants’ lives, the field may be replete with tensions that may affect the researcher. This paper brings the concept of micro-ethics to family marketing literature, showing how researchers can do ethics in practice. The paper draws on reflexive accounts of two researchers’ personal experiences, showing their emotional, practical, positioning and display challenges. It also provides practical strategies for researchers to deal with dilemmas in the field.
Corporate social reporting in the banking industry of Bangladesh: a test of legitimacy theory
Authors: Islam Mohammad Tazul , Kokubu Katsuhiko , Nishitani Kimitaka 
Published: February 2020

PurposeThe purpose of this study is to test the legitimacy theory (LT) argument in the context of the banking industry of a developing country, taking Bangladesh as a case by interpreting the bank managers’ perceptions in legitimizing corporate social (CS) reporting.Design/methodology/approachThis study uses the Dhaka Stock Exchange (DSE) listed banks data during a 10-year period (2004–2013) and uses Islam and Kokubu (2018) CS reporting index. The LT variables are tested by using multiple regression method. A mixed-method of research with “triangulation design” has been used in this study for a comprehensive understanding of LT variables. In addition, a total number of 28 interviews (ranges from Corporate Social Responsibility Operational Manager to Managing Director/Chief Executive Officer) from 24 listed banks have been conducted to interpret bank managers’ legitimate perception in CS reporting.FindingsThis study supports the applicability of the broader thrust of LT for the banking industry of the developing economies in three ways. First, for companies with lower “proximity to end-users” by density in population disclose more social information than the companies with higher ones to gain/regain/maintain market legitimacy. Second, newer banks with less scope to reach proximity to end-users disclose more social information to fill proximity to tertiary clients’ gap to meet community expectation. Third, companies disclose more social information in their annual reports to legitimize corporate actions in response to the CS reporting initiatives taken by the stakeholders, particularly regulators.Research limitations/implicationsThe main implication of this study is that it extends the applicability of the LT for the developing country, in general, and for the banking industry, in particular.Originality/valueThe study enriches the existing LT literature of the developing economies’ banking industry by providing empirical evidence from the banking system in Bangladesh.