bluuebunny/crossref_metadata_2025_split huggingface dataset:
LAYING THE GROUNDWORK FOR BECOMING AN AGE-FRIENDLY UNIVERSITY: A MULTI-PHASE STUDY
Authors: Cannon Melissa L , Kerwood Renata , Kondash Mandie , Rowley Samuel , Wehr Hannah 
Published: November 2019

Abstract
As evidenced by the growing Age-Friendly University (AFU) global network, institutions of higher education are increasingly seeking ways to enhance the experiences of older adults who use them for reasons such as lifelong learning, career development, and intergenerational engagement. This multi-phase study explored the barriers and facilitators for older adults accessing a public university in a small Oregon town. The first phase of the study involved survey data collection from 46 members of the local senior center adjacent to the university campus. For the second phase, researchers recruited a sample from the survey respondents and used snowball sampling to conduct 12 interviews with senior center members, past and current senior center directors, and key contacts among university staff. The third phase of data collection paired student researchers with older adult research participants (N=14) in participatory action research to capture the unique perspectives of the research participants visiting the university campus using photovoice and a follow-up focus group. Quantitative data were analyzed using SPSS while qualitative data were analyzed using team coding and intensive group discussion to develop categories and themes. Findings revealed various opportunities to increase age-friendliness according to the principles outlined by the AFU initiative, such as developing a lifelong learning center on campus, strengthening the university-senior center partnership, and removing accessibility barriers in order to make the university campus friendlier for people of all ages and abilities. These findings are being used in a proposal to join the AFU network and to shape the university’s AFU vision.
EFFECTS OF PRODUCTIVE ENGAGEMENT ON SUBJECTIVE HEALTH AMONG OLDER ADULTS WITH SENSORY IMPAIRMENTS
Authors: Lee Othelia E , Park Junghyun 
Published: November 2019

Abstract
Background: Productive engagement becomes significant protective factors in healthy aging. Yet, subgroups of older adults with age-related vision and hearing impairments lack access to various activities , suggesting that unequal ability to participate in productive aging is a major public health and health-disparities concern. Methods: Older adults experiencing age-related vision and hearing impairments were drawn from the 2015-2017 National Survey on Drug Use and Health (n=2,164). Perceived health status (good vs. poor) was outcome measures used in multivariate logistic regression. Two aspects of productive engagement was considered: 1) employment status (unemployed vs employed) and 2) regular religious service attendance as tools to build social capital in their faith-based communities. Gender, race, marital status, educational attainment, poverty, urbanization, obesity, chronic disease, hospitalization, binge drinking, cigarette smoking, and difficulty with mobility were considered as covariates. Results: Working older adults with sensory loss were more likely to perceived good health status, compared to their unemployed counterparts (OR=2.46, p&lt;.05). Religious service attendance also became protective factors for health (OR=1.60, p&lt;.01). Of the covariates, higher educational attainment, White race, having one chronic disease, hospitalization, smoking, drinking, and mobility challenges appeared to affect the health status. Conclusions/Implications: Study findings implied the needs to identify late-life engagement through work and participation in faith-based community as a major public health issue. Given the barriers and disincentives to the productive engagement of older adults in this culture, healthcare providers should provide programs promoting employment and religious attendance.
PROMOTION OF CULTURAL GENERATIVITY TO SUPPORT SUCCESSFUL AGING IN ALASKA NATIVE COMMUNITIES
Authors: Kim Steffi M , Lewis Jordan P 
Published: November 2019

Abstract
The psychological construct of generativity encompasses a person’s motivation to leave a legacy for future generations by investing in acts that will outlive the self (Ericson, 1950). Lewis and Allen (2017) outlined the importance of generativity within AN cultures (caring for the future of our youth) and expanded Erikson’s western-based definition by adding the indigenous cultural generativity component to describe and incorporate Alaska Native specific cultural elements. These culturally based elements involve giving back to family and community including guidance and teaching of future generations (Lewis & Allen, 2017). Generativity within western societies accentuates independent achievements and successes more than the notion to care for future generations. This study is part of a larger community-based, exploratory, study between researchers and communities to explore successful aging that included 42 Alaska Native Elders in the Norton-Sound subregion, 21 Alaska Native Elders from the Aleutian Pribilof Islands, and 26 Elders from the Bristol Bay region. Qualitative interviews explored the participant’s life, influences on aging well, and their aging process. Thematic analysis was used to investigate the impact of generativity on successful aging was used to establish codes and main themes based on the three different cultural regions of Alaska. The findings suggest that generativity promotes successful aging. Elders who live in communities that promote community engagement, support family and school activities, and maintain and/or revitalize culture and traditions reported increased emotional well-being. Results can guide communities to incorporate or support cultural activities that promote generative activities and meaningful engagement which fosters successful aging.
AFU PRINCIPLES IN ACTION: ENGAGING STUDENTS THROUGH HANDS-ON AGE-RELATED ACTIVITIES
Authors: Barragan Cassandra , Wladkowski Stephanie 
Published: November 2019

Abstract
The Age-Friendly University (AFU) Initiative is a global network of universities working to embrace and promote the growing population of older adults (OAs) on campuses. Integrating inter-generational learning is a proven benefit to share knowledge (Gerpott, Lehmann-Willenbrock, & Velopel, 2017) and to mutually benefit both older and more traditional learners (Pstross, Corrigan, Knopf, et al., 2017). To thoughtfully develop AFU initiatives on their campus, one midwestern university created an educational activity for students to better understand the needs of OAs. This presentation will cover results of this activity and offer suggestions for aging-focused learning activities. In winter 2019, 23 undergraduate students from 5 disciplines participated in a guided sensory activity with 5 Masters in Social Work (MSW) students that simulated impaired vision, hearing, and dexterity. Afterwards, using the AARP walking audit, they walked campus to understand challenges those with limitations might face. Students then completed a guided reflection and thought of ways to advocate for anyone with physical challenges, both off and on campus. This activity resulted in several successful learning outcomes and provided concrete experiences, establishing grounds to think about advocacy in a practical way. First, the undergraduate students presented their experiences at a campus-wide activism and advocacy event. They aimed to 1) increase awareness of the challenges those with visual and physical challenges and 2) promote the AFU initiatives. MSW students further analyzed their experience from a policy perspective and presented to the AFU steering committee with recommendations to influence policy in alignment with the AFU principles.
THE ROLE OF CAPRIN-1 PROTEIN DYSREGULATION IN SYNAPSE DECLINE LEADING TO PROGRESSION OF TAUOPATHIES
Authors: Fastenau Caitlyn , Cifuentes Helen , Kauwe Grant , Tracy Tara 
Published: November 2019

Abstract
Many neurodegenerative diseases are characterized by accumulation of proteins such as tau, a microtubule stabilization protein. Toxic tau forms tangles and affects neuronal synapse function, an early step of neurodegeneration. To focus on synapse function, we highlighted Caprin-1 protein. Through gene ontology, Caprin-1 is related to RNA granule proteins, important for transport and local translation in dendrites. Caprin-1 is of interest for neurodegeneration because it is a memory related protein, transports mRNA in RNA granules, and knock out mice demonstrate memory deficits. As we age, the performance of local translation in the dendrites is compromised and leads to synapse dysfunction. We hypothesize Caprin-1 binds to Tau and becomes disrupted. This leads to the dissolution of RNA granules, inhibition of mRNA transport in dendrites, suppression of translation, and failure of synapse. Early western blot data showed reduced Caprin-1 in PS19 Tau+, supporting our model that Caprin-1 is disrupted in disease models. Through immunohistochemistry, we investigated the localization of Caprin-1 in the mouse hippocampus. We observed Caprin-1 localization to dendrites of CA1 neurons in the hippocampus. Furthermore, Caprin-1 exhibited colocalization with Rps6, an RNA granule marker. This suggests Caprin-1 associates with RNA granules in mouse hippocampus. Finally, we investigated the localization of Caprin-1 in human iPSC-derived neurons. Similar to the mouse hippocampus, we observed localization of Caprin-1 to dendrites of human neurons. In future directions, we will examine whether pathogenic tau alters the association of Caprin-1 with RNA granules and the mechanisms by which pathogenic tau negatively effects synapse function.
WALKING AWAY FROM LONELINESS: THE MEDIATING ROLE OF SOCIAL ISOLATION
Authors: Shellito Natalie , Roldan Nidya Velasco 
Published: November 2019

Abstract
This study examines the relationship between physical activity (PA) and loneliness among older adults. Participation in walking enables individuals to come into contact with other people, thus social isolation may mediate the relationship between walking and loneliness. The study uses participants from the Leave Behind Questionnaire of the 2016 data wave of the Health and Retirement Study with a sample size of 6,157. The dependent variable, loneliness, is measured using the 11-item UCLA Loneliness Scale and the independent variable, walking, is measured as participants who walk 20 minutes or more per day. The mediator, social isolation, is measured using a standardized 9-item score, including closeness and frequency of contact with children, friends, and other family members, and participation in group activities. We analyzed the effect of walking on loneliness and the role of social isolation as a mediator of that relationship using structural equation modeling. Our results suggest that walking is significantly associated with lower levels of both social isolation (B=-.10) and loneliness (B=-.05). As well, there is a positive association between social isolation and loneliness, as social isolation increases, so does loneliness (B=0.31). Moreover, results from the mediation analysis using bootstrapping suggest that social isolation partially mediates the relationship between walking and loneliness (B=-.03). Our findings confirm the benefits of PA on wellbeing. This research provides evidence that suggests establishing walking programs may decrease the risk of loneliness. Future interventions concentrated on lowering social isolation through PA among older adults should consider the opportunity to reduce loneliness.
DESCRIBING A CONCEPT OF NURSE INTUITION AND IMPLICATIONS FOR DEMENTIA CARE IN NURSING HOMES
Authors: Perkins Rebekah , kather Katherine Supiano’katherine supiano@hsc utah edu’ 
Published: November 2019

Abstract
The purpose of this concept analysis was to explore nurse intuition historically and in current literature, appraise the value of nurse intuition to research and practice, and discuss implications for practice in caring for residents with behavioral and psychological symptoms of Dementia (BPSD) in nursing homes. To date, no research has examined the presence or utility of nurse intuition in the nursing home setting. A conceptual analysis using pragmatic utility was chosen and based on the work of Walker and Avant (2005). In the literature, nurse intuition is characterized by attributes of knowledge not preceded by inference, knowledge that is holistic in nature, independent of linear thinking, and drawn from synthesis instead of analysis. Nurse intuition is based on preconditions of experience, empathy, limited information, and limited time to make vital decisions about patient care. Studies on nurse intuition have been criticized for their lack of rigor and empirical evidence of the effect of nurse intuition on positive patient outcomes. The attributes of intuitive nursing practice have important implications in nursing applied to residents with BPSD. The nursing home nurse with extensive educational and experiential knowledge is well-situated to understand the complex, changing needs of residents exhibiting various forms of BPSD in an effort to communicate their needs. Future studies on nurse intuition should focus on early education in dementia care, nurse residency-mentor programs to enhance intuitive thinking in the management of BPSD, and more empirical studies on the use of intuition in the context of dementia care.
“WITH AGE COMES WISDOM:” A QUALITATIVE REVIEW OF ELDER PERSPECTIVES ON HEALTHY AGING IN THE CIRCUMPOLAR NORTH
Authors: Howell Britteny M , Peterson Jennifer R 
Published: November 2019

Abstract
Cross-cultural research has shown marked variation in health outcomes across the world’s older adult populations. Indeed, older adults in the Circumpolar North experience a variety of health disparities. Because aging is a biological process rooted in sociocultural context, there exists great variation in the ways older adults define and experience healthy, or “successful,” aging in their communities. The aim of this analysis was to synthesize qualitative research among older residents (aged 50+ years) in the Circumpolar North to identify a definition of healthy aging common in the region. A thorough review was conducted across a variety of academic search databases for peer-reviewed, qualitative studies conducted among community-dwelling older adults. The search strategy initially identified 194 articles; 23 articles met the inclusion criteria. Included studies were coded and analyzed using Grounded Theory to examine underlying themes of healthy aging in the Circumpolar North. The findings reveal the importance older adults place on respect, their relationship to the land, and psychosocial resilience into multidimensional models of healthy aging. We present a complex concept map demonstrating how healthy aging perspectives fit together into a multidimensional model of health in the Circumpolar North. This research also highlights the need for increased translational research with populations in the Circumpolar North that are under-represented in the literature.
INCREASED C3 IN THE AGING BRAIN PROMOTES INFLAMMATORY TRANSITION IN ENDOTHELIAL CELLS
Authors: Propson Nicholas E , Litvinchuk Alexandra , Roy Ethan R , Contreras Bianca , Cao Wei , Zheng Hui 
Published: November 2019

Abstract
Innate immunity has been implicated in normal aging, and age-related disease. The connection between age-related neuroinflammation and change in brain vasculature prior to disease onset remains poorly understood. The complement pathway is an established mediator of neuroinflammation, and increased complement C3 is seen in the aging brain. Thus, we asked whether C3 can promote changes in brain vasculature. We found age dependent increase of brain C3 levels in C57BL/6J mice. Furthermore, we found an increase in expression of adhesion molecule VCAM-1 in endothelial cells (ECs) of the cortex and hippocampus, which was rescued in aged C3a receptor null (C3ar1-/-) mice and aged C3a receptor (C3aR) antagonist treated mice. We confirmed these results by qPCR analysis for Vcam1 in sorted ECs. Human brain microvascular endothelial cells (HBMECs) treated with C3a showed increased expression of VCAM-1, but not other adhesion molecules. Sorted ECs from C3ar1-/- mice challenged with LPS confirmed these findings. Furthermore, C3aR signaling in ECs showed increased blood-brain barrier (BBB) permeability using trans-endothelial electrical resistance (TEER), and BBB impermeable dye injections. HBMECs treated with C3a revealed mis-localization of VE-Cadherin, followed by reduction in protein level when analyzed by immunofluorescence, which promotes increased barrier permeability. As a functional consequence of VCAM-1 expression and increased BBB permeability we found aged mouse brains have increased peripheral lymphocyte (CD45+/CD11b-) infiltration, which was reduced in a C3aR dependent manner. In conclusion, our work suggests there is a strong relationship between C3 expression and vascular C3aR contributing to a functional transition in endothelial cells during aging.
ANGER, LOVE, SADNESS: DO EMOTION WORDS HAVE THE SAME SEMANTIC MEANING ACROSS AGE-GROUPS?
Authors: Nichols Madeline J , Bellingtier Jennifer A , Buttelmann Frances 
Published: November 2019

Abstract
Every day we use emotion words to describe our experiences, but past research finds that the meanings of these words can vary. Furthermore, historical shifts in language use and experiential knowledge of the emotions may contribute to age-differences in what these emotion words convey. We examined age-related differences in the valence, arousal, and expression connoted by the words anger, love, and sadness. We predicted age-related differences in the semantic meanings of the words would emerge such that older adults would more clearly differentiate the positivity/negativity of the words, whereas younger adults would report higher endorsement for the conveyed arousal and expression. Participants included American and German older adults (N=61; mean age=68.98) and younger adults (N=77; mean age=20.77). Using the GRID instrument (Swiss Center for Affective Sciences, 2013), they rated each emotion word for its valence, arousal, and expression when used by a speaker of the participant’s native language. Across emotions and dimensions, older adults were generally more moderate in their understanding of emotion words. For example, German older adults rated anger and sadness as suggesting the speaker felt less bad and more good than the younger adults. American older adults rated love as connoting the speaker felt more bad and less good than younger adults. Arousal ratings were higher for German younger, as opposed to older, adults. Cultural differences were most pronounced for sadness such that German participants gave more moderate answers than American participants. Overall, our research suggests that there are age-related differences in the understanding of emotion words.
LIPOPOLYSACCHARIDE BINDING PROTEIN IS ASSOCIATED WITH LOWER CVD RISK IN OLDER ADULTS
Authors: Roberts Lisa , Buford Thomas W 
Published: November 2019

Abstract
Intestinal (i.e. “gut”) permeability may be related to cardiovascular disease (CVD) risk, but biomarkers for gut permeability are limited and associations with CVD risk are unknown – particularly among older adults. This cross-sectional study aimed to determine if serum biomarkers related to gut permeability [intestinal fatty acid-binding protein (iFABP)] and bacterial toxin clearing [cluster of differentiation 14 (CD14), lipopolysaccharide binding protein (LBP)] are associated with CVD risk among older adults. Older adults (n = 38, 72.0 ± 7.1 years old) were stratified by CVD risk category (Adult Treatment Panel: moderate, high-moderate, high). One-way ANOVAs determined differences in each biomarker by risk category, and associations with risk score were evaluated via linear regression and/or Pearson correlations. LBP (p &lt; 0.001), but not iFABP and CD14 (p’s &gt; 0.05), was significantly different between CVD risk categories. Post-hoc tests indicated LBP was higher in the moderate risk compared to both higher risk categories (p &lt; 0.005). LBP was a significant predictor of 10-year CVD risk (β = -0.629; p = 0.001) and evaluation of individual components in the risk score demonstrated a moderate, positive correlation of LBP with total cholesterol (r = 0.326, p = 0.046). Higher circulating concentrations of LBP were associated with lower CVD risk among older adults. Further, total cholesterol was positively associated with circulating levels of LBP. Importantly, cholesterol assists LBP in clearing bacterial toxins from circulation by transporting toxins for removal. These data suggest LBP may be a key component in reducing CVD risk in older adults.
THE ROLE OF FOXO3 TRANSCRIPTION FACTOR IN ALZHEIMER’S DISEASE PATHOLOGY
Authors: Du Shuqi , Maneix Laure , Zhang Qinghao , Wan Ying-Wooi , Zheng Hui 
Published: November 2019

Abstract
Alzheimer’s disease (AD) is a progressive and degenerative brain disease and age is one of its strongest risk factors. Aging is a complex process but it is reasonable that a delayed aging process may lower the risk of AD or postpone its pathogenesis. Studies in C. elegans revealed that the activity of DAF-16 is required for the life span extension in many long-lived strains. The mammalian homologs for DAF-16 are the Forkhead box O (FOXO) transcription factors. FOXO3, one of the members in the FOXO family, has been identified in several studies as a susceptibility gene for human longevity. I found that the expression level of Foxo3 in the mouse brain decreases with age or in an AD mouse model. To further study the role of Foxo3 in AD, I generated Foxo3 conditional knockout mice which depletes Foxo3 in neural cells. These mice have reactive astrogliosis in the cortex and also upregulation of some astrocytes specific markers like Gfap and Aqp4. In vitro culture of primary astrocytes from the knockout mice shows impaired respiratory capacity in the Seahorse mito stress test, which corresponds to the expression level change of metabolic genes like Acot1. When we bred the knockout mice with 5xFAD, a mouse model for amyloid pathology. I found increased plaque load and core plaque size in the cortex of the mice with Foxo3 deficiency. This study shows the critical function of FOXO3 in maintaining brain homeostasis and provide new insights into AD pathogenesis and drug discovery.