bluuebunny/crossref_metadata_2025_split huggingface dataset:
درجة ممارسة معلمي ومعلمات التربيةالاجتماعية في لواء وادي السير بمحافظة العاصمة الأردنية لمهارات تنمية التفكير الإبداعي
Authors: Al- Aharab Asma Farhan 
Published: October 2020

الملخص:
هدفت الدراسة الحالية التعرف إلى درجة ممارسة معلمي ومعلمات التربية الاجتماعية في لواء وادي السير بمحافظة العاصمة الأردنية لمهارات تنمية التفكير الإبداعي من وجهة نظرهم أنفسهم. ولتحقيق هدف الدراسة تم تطوير استبانة مكونة (44) فقرة موزعة على خمسة مجالات: (مهارة الطلاقة، ومهارة المرونة، ومهارة الأصالة، ومهارة التفاصيل، ومهارة الحساسية للمشكلات). وتكونت عينة الدراسة من جميع معلمي ومعلمات التربية الاجتماعية في لواء وادي السير بمحافظة العاصمة الأردنية والبالغ عددهم (105) معلماً ومعلمة، وتم استبعاد عينة الثبات من إجمالي عدد المجتمع، وكذلك الاستبانات التي تم تستوفي شروط التحليل الإحصائي. وبذلك تكونت عينة الدراسة النهائية من (75) معلماً ومعلمة. وقد أظهرت نتائج الدراسة أن درجة ممارسة معلمي ومعلمات التربية الاجتماعية في لواء وادي السير بمحافظة العاصمة الأردنية لمهارات تنمية التفكير الإبداعي كانت متوسطة وفي جميع المجالات. كما أظهرت النتائج عدم وجود فروق ذات دلالة إحصائية تعزى إلى متغير الجنس في جميع مجالات الدراسة باستثناء مجال مهارة الأصالة والأداة ككل وجاءت الفروق لصالح (الإناث)، وعدم وجود فروق ذات دلالة إحصائية تعزى إلى متغير سنوات الخبرة في جميع مجالات الدراسة والأداة ككل باستثناء مجال مهارة الأصالة وجاءت الفروق لصالح (11 سنة فأكثر).
الكلمات المفتاحية:درجة ممارسة، معلمي ومعلمات التربية الاجتماعية، التفكير الإبداعي.
Extent of Practicing Creative Thinking Skills among Students of Educational Technology at the University of Ibb, Yemen, When Applying Innovative Educational technologies
Authors: يحي الحدابي أ.د. داود عبدالملك , صالح د. عيسى 
Published: October 2020

The research aimed to identify the extent of practicing creative thinking skills among students of educational technology at the University of Ibb, Yemen in applying innovative educational technologies. To achieve the objectives of the study and answer its questions, the researchers used the descriptive method. The study population was educational technology students at the University of Ibb. The research sample involved (50) students of the second level in the Department of Educational Technology in the academic year 2018/ 2019. A scale of creative thinking and an open-ended questionnaire were used to assess creative thinking skills and identify the obstacles of creative thinking among students. The results showed a clear decline in the students' ability to practice creative thinking skills with a general average of (34.90) for group A students, and an average of (35.15) for group B students. The study revealed a number of obstacles of developing students' creative thinking. The study concluded with a set of recommendations and suggestions.
Keywords: creative thinking skills, educational technology innovations, students of educational technology.
Effectiveness of the Physics Crocodile Software Program in Enhancing Exploration Skills among Grade (8) Students and their Attitudes toward the Program
Authors: المنوري سعيد بن سيف , بن محمد المجيني علي بن حسن , بن مبارك الحراصي سالم بن العبد 
Published: October 2020

This study aimed to evaluate the effectiveness of the Physics Crocodile software Program to enhance the exploration skills among eighth grade pupils and their attitudes toward using the program. The researchers used both semi-experimental and descriptive methods to achieve the objectives of the study. An achievement test was built to measure the effectiveness of using the Physics Crocodile Software Program on the sample. Moreover, a questionnaire was also used to assess students' attitudes toward using the Physics Crocodile Software Program. These tools were administered to a sample of (40) students of grade eight, divided equally into 2 groups: the experimental group and the control group. The study results showed statistically significant differences between the experimental group and the control group in the post-test. However, there was a positive attitude in using the program among the experimental group. The study recommended integrating educational software programs into traditional teaching methods, so as to use it in all school subjects.
Keywords: physics crocodile, exploration skills.
A novel E-subgroup pentatricopeptide repeat protein DEK55 is responsible for RNA editing at multiple sites and splicing of nad1 and nad4 in maize
Authors: Ren Ru Chang , Yan Xu Wei , Zhao Ya Jie , Wei Yi Ming , Lu Xiaoduo , Zang Jie , Wu Jia Wen , Zheng Guang Ming , Ding Xin Hua , Zhang Xian Sheng , Zhao Xiang Yu 
Published: October 2020

Abstract
Background: Pentatricopeptide repeat (PPR) proteins form a large protein family that participates in RNA processing in organelles and plant growth. Previous reports regard E-subgroup PPR proteins as editing factors for RNA editing. However, additional functions and roles of the E-subgroup PPR proteins remain to be investigated.Results: In this study, we developed and identified a new maize kernel mutant with arrested embryo and endosperm development, i.e., defective kernel 55 (dek55). Genetic and molecular evidence suggested that the defective kernels was a result of a mononucleotide alteration (C to T) at +449 bp in the open reading frame (ORF) of Zm00001d014471 (hereafter referred to as DEK55). DEK55 encodes an E-subgroup PPR protein within mitochondria. Molecular analyses showed that the editing ratio of 24 RNA editing sites was decreased and that of seven RNA editing sites was increased in dek55 mutant kernels, which were distributed in 14 mitochondrial gene transcripts. Meanwhile, the splicing efficiency of the nad1 introns 1 and 4 and nad4 intron 1 was significantly decreased in dek55 compared with that of wild-type (WT). These results indicate that DEK55 plays a crucial role in RNA editing at multiple sites as well as in the splicing of nad1 and nad4 introns. Mutation in the DEK55 gene led to the dysfunction of mitochondrial complex I. Yeast two-hybrid assays showed that the DEK55 interacts with two multiple organellar RNA editing factors (MORFs), i.e., ZmMORF1 (Zm00001d049043) and ZmMORF8 (Zm00001d048291), respectively.Conclusions: Our results demonstrated that a mutation in the DEK55 gene affects the mitochondrial function essential for maize kernel development. Our results also provide novel insight into the molecular functions of the E-subgroup PPR proteins in plant organellar RNA processing.
Over-expression of ANP32E is associated with poor prognosis of pancreatic cancer and promotes cell proliferation and migration through regulating β-catenin
Authors: Zhang Jianwei , Lan Zhongmin , Qiu Guotong , Ren Hu , Zhao Yajie , Gu Zongting , Li Zongze , Feng Lin , He Jin , Wang Chengfeng 
Published: October 2020

Abstract
Background: Pancreatic cancer is a malignant tumor with high mortality. Acidic nuclear phosphoprotein 32 family member E (ANP32E), a specific H2A.Z chaperone, has been shown to contribute to breast cancer development. However, the significance of ANP32E in pancreatic cancer is poorly understood. This study aimed to investigate the role of ANP32E in pancreatic cancer.
Methods: The expression of ANP32E in 179 pancreatic cancer tissues and 171 normal tissues, and the correlation between ANP32E expression and patients’ survival were analyzed from the TCGA database. ANP32E was over-expressed and silenced using lentivirus. siRNA was used to knock down β-catenin. CCK8, colony formation, cell cycle and transwell experiments were performed to determine cell proliferation and migration. qRT-PCR and Western blot were conducted to detect mRNA and protein expression.
Results: ANP32E was up-regulated in pancreatic cancer tissues and cells. Up-regulation of ANP32E predicted poor prognosis in pancreatic cancer patients. Lentivirus-mediated knockdown of ANP32E suppressed the proliferation, colony growth and migration of PANC1 and MIA cells. By contrast, ANP32E over-expression promoted the proliferation and migration of both cells. In addition, ANP32E accelerated the cell cycle progression in PANC1 and MIA cells. Molecular experiments showed that ANP32E activated β-catenin/cyclin D1 signaling. Silencing of β-catenin reduced cell proliferation and migration in ANP32E over-expressed cells.
Conclusion: Our results propose that ANP32E functions as an oncogene in pancreatic cancer via activating β-catenin.
Leadership, governance and management for improving district capacity and performance: the case of USAID Transform: Primary Health Care
Authors: Desta Binyam Fekadu , Abitew Azeb , Beshir Ismael Ali , Argaw Mesele Damite , Abdlkader Sualiha 
Published: October 2020

Abstract
Primary health care (PHC) in Ethiopia serves as the main entry point for preventive, promotive and curative health services. The district health office is responsible for the planning, implementation and evaluation of all district health activities. In addition, district health offices manage service delivery facilities working on provision of PHC – primary hospitals, health centers and health posts. As the leader of the health care system tier, district health management must ensure direction, alignment and commitment within teams and organizations and make sure that achievements are consistent with the vision, values and strategy of the organization. USAID Transform: Primary Health Care provides diverse support to improve district health manager competencies including in-service trainings followed by planning and implementation of performance improvement projects and on-the-job mentoring and support. This study was conducted to compare district level capacity and performances between leadership, management and governance (LMG) and non-LMG districts. Project outcome monitoring data that shows the performance of districts was collected from 284 districts from January to December 2019. The study was carried out using a comparative-cross sectional study design, which assessed and compared district health office level indicators. Districts were classified into two categories: LMG and non-LMG districts. The study compared data from 94 LMG and 190 non-LMG districts. Propensity score matching was used to control the effect of differences between LMG and non-LMG districts. Results of the independent samples t-test revealed that LMG districts scored better average performances of 61.8±121.45 standard deviation (SD) compared to non-LMG districts 56.89±110.39 SD, with t (282243) = -3.407317 and p < 0.001, two-tailed. The difference of 4.9 percentage unit in the average performance indicated a statistically significant difference between the LMG and non-LMG districts. The data analysis illustrated significant differences observed in management practices, district administrative capacity, and quality in project implementation sites.
Spectrum Sensing in Cognitive Radio Networks: Threshold Optimization and Analysis
Authors: kockaya kenan , Develi İbrahim 
Published: October 2020

Abstract
Cognitive radio (CR) is a technology developed for the effective use of radio spectrum sources. The spectrum sensing function plays a key role in the performance of cognitive radio networks. In this study, a new threshold determination method based on online learning algorithm is proposed to increase the spectrum sensing performance of spectrum sensing methods and to minimize the total error probability. The online learning algorithm looks for the optimum decision threshold, which is the most important parameter to decide the presence or absence of the primary user, using historical detection data. Energy detection and matched filter based spectrum sensing methods are discussed in detail. The performance of the proposed algorithm was tested over non-fading and different fading channels for low signal-to-noise ratio (SNR) regime with noise uncertainty. In the conclusion of the simulation studies, improvement in spectrum sensing performance according to optimal threshold selection was observed.
Investigation on Yield Behavior of 7075-T6 Aluminum Alloy at Elevated Temperatures
Authors: Lin Jianping , Bao Xingyu , Hou Yong , Min Junying , Qu Xinlei , Tao Zhimin , Chen Jiajie 
Published: October 2020

Abstract
Aluminum alloys have drawn considerable attention in the area of automotive lightweight. High strength aluminum alloys are usually deformed at elevated temperatures due to their poor formability at room temperature. In this work, the yield behavior of 7075 aluminum alloy in T6 temper (AA7075-T6) within the temperature ranging from 25 ℃ to 230 ℃ was investigated. Uniaxial and biaxial tensile tests with the aid of induction heating system were performed to determine the stress vs. strain curves and the yield loci of AA7075-T6 at elevated temperatures, respectively. Von Mises, Hill48 and Yld2000-2d yield criteria were applied to predicting yield loci which were compared with experimentally measured yield loci of the AA7075-T6. Results show that yield stress corresponding to the same equivalent plastic strain decreases with increasing temperature within the investigated temperature range and the shape of yield loci evolves nearly negligibly. The experimental yield locus expands with an increase of equivalent plastic strain at the same temperature and the work hardening rate of AA7075-T6 exhibits obvious stress-state-dependency. The non-quadratic Yld2000-2d yield criterion describes the yield surfaces of AA7075-T6 more accurately than the quadratic von Mises and Hill48 yield criteria, and an exponent of 14 in the Yld2000-2d yield function gives the optimal predictions for the AA7075-T6 at all investigated temperatures.
Pelvic Organ Prolapse and Uterine Preservation: A survey of female gynaecologists (POP-UP survey)
Authors: Urdzík Peter , Kalis Vladimir , Blaganje Mija , Rusavy Zdenek , Smazinka Martin , Havir Martin , Dudic Rastislav , Ismail Khaled M 
Published: October 2020

Abstract
Background: The aim of this study was to explore the personal views of female gynecologists regarding the management of POP with a particular focus on the issue of uterine sparing surgery.Methods: A questionnaire based survey of practicing female gynecologists in the Czech Republic, Slovenia and Slovakia.Results: A total of 140 female gynecologists from 81 units responded to our questionnaire. The majority of respondents stated they would rely on a urogynecologist to aid them with their choice of POP management options. The most preferred options for POP management were sacrocolpopexy and physiotherapy. Almost 2/3 of respondents opted for a hysterectomy together with POP surgery, if they were menopausal, even if the anatomical outcome was similar to uterine sparing POP surgery. Moreover, 81.4% of respondents, who initially opted for a uterine sparing procedure, changed their mind if the anatomical success of POP surgery with concomitant hysterectomy was superior. Discussing uterine cancer risk in relation to other organs had a less significant impact on their choices.Conclusions: The majority of female gynecologists in our study opted for hysterectomy if they were postmenopausal at the time of POP surgery. However, variation in information provision had an impact on their choice.
Changes in treatment strategy over time for arteriovenous malformation in a Japanese high-volume center
Authors: Komatsu Katsuya , Takagi Yasushi , Ishii Akira , Kikuchi Takayuki , Yamao Yukihiro , Yoshida Kazumichi , Miyamoto Susumu 
Published: October 2020

Abstract
Background: Despite rapid developments in devices used to treat arteriovenous malformation (AVM), a randomised trial of Unruptured Brain Arteriovenous malformations published in 2014 recommended conservative treatment for nonhemorrhagic AVM. Objective: The purpose of the current retrospective study was to confirm how AVM treatment in Japan has changed and to assess the safety of treatment for hemorrhagic and nonhemorrhagic AVMs.Methods: We enrolled 242 consecutive patients with AVM; each patient’s treatment was selected and performed at our hospital. The type of onset, Spetzler–Martin (S–M) grade, age, sex, selected treatment, mortality, and morbidity were compared between the first and second periods of our study.Results: In patients with grade I–III AVM, the selected treatment changed between the first and second periods; however, in grade IV and V patients, the selected treatment did not change. Overall, interventions by microsurgery alone decreased (p < 0.001), the proportion of total treatments including microsurgery decreased (p = 0.005), interventions using stereotactic radiosurgery (SRS) alone increased (p = 0.009), and interventions including SRS increased (p = 0.002). Morbidity associated with intervention was 0.92% in the first period and 0% in the second period, and mortality was 0.92% in the first period and 1.67% in the second. Conclusions: With the development of new devices, the selected treatment was changed in patients with S–M grade I–III AVM, but was not changed in patients with grade IV and V. The complication rate was low and did not change throughout the periods. These findings suggest that the safety of treatment depends on a full understanding of device development and the selection of proper treatment, not on hemorrhagic onset. Further treatment innovations are expected to change the treatment for grade IV and V AVMs.
Heg.IA: An intelligent system to support diagnosis of Covid-19 based on blood tests
Authors: Barbosa Valter Augusto de Freitas , Gomes Juliana Carneiro , Santana Maíra Araújo de , Albuquerque Jeniffer Emídio de Almeida , Souza Rodrigo Gomes de , Souza Ricardo Emmanuel de , Santos Wellington Pinheiro dos 
Published: October 2020

Abstract
A new kind of coronavirus, the SARS-Cov2, started the biggest pandemic of the century. It has already killed more than 250,000 people. Due to this fact, it is necessary quick and precise easily available diagnosis tests. The current Covid-19 diagnosis benchmark is RT-PCR with DNA identification, but its results takes too long to be available. Tests based on IgM/IgG antibodies have been used, but their sensitivity and specificity may be very low when viral charge is reduced. Many studies have been demonstrating the Covid-19 impact in hematological parameters. This work proposes an intelligent system to support Covid-19 diagnosis based on blood testing. We employed a dataset provided by Hospital Israelita Albert Einstein, a Brazilian private hospital. The database contains the results of more than one hundred laboratory exams, such as blood count, tests for the presence of viruses such as influenza A, and urine tests, of 5644 patients. Among these patients, 559 of them are infected with SARS-Cov2. We used metaheuristics algorithms to reduce the set of We tested several machine learning methods, and we achieved high classification performance: 95.159% +- 0.693 of overall accuracy, kappa index of 0.903 +- 0.014, sensitivity of 0.968 +- 0.007, precision of 0.938 +- 0.010, and specificity of 0.936 +- 0.011. Experimental results pointed out to Bayes Network as the best configuration. In addition, only 24 blood tests were needed. This points to the possibility of a new low cost rapid test based on common blood exams and intelligent software. The desktop version of the system is fully functional and available for free use.
Dengue virus non-structural protein 1 disrupts the TGF-β/Smad signaling&nbsp;
Authors: Lahon Anismrita , Arya Ravi , Kumar Vivek , Mishra Ritu , Banerjea Akhil 
Published: October 2020

Abstract
TGF-β signaling is tightly regulated to ensure cellular functions. Role of DENV on the TGF-β/Smad signaling has not been well established. Therefore, we aimed to study the association between DENV infection and TGF-β/Smad signaling. We observed significant impairment in the expression of Smad2, Smad3, Smad4, Smad6 and Smad7 during DENV replication, which are the key players in TGF-β signaling. Significant reduction in the expression of phosphorylated Smad3 was also documented. Overexpression of Smad2/3/4/6 provided the evidence of slight inhibition on DENV replication indicating these Smads may work against the establishment of DENV replication. DENV non-structural protein 1 (NS1) was noted as crucial viral factor that impaired the expression of Smad2, Smad3 and Smad4 and also physically interacts with these proteins as confirmed by co-immunoprecipitation assay. Additionally, we observed NS1 is also capable of blocking the nuclear translocation of Smad3 and thus further ensuring inhibition of Smad signaling. To figure out degradation mechanisms, we studied the role of two distinct E3 ligases, CHIP and Smurf2, which are essential for the degradation of Smad proteins. Co-expression of Smad2/3/4 and NS1 with Smurf2, Smurf2mut, CHIP or use of CHIP-/- cells suggests that only Smurf2 has significant role in the degradation of Smad proteins during DENV infection. NS1 may acts as a co-factor with Smurf2 to escalate the proteasome and lysosome mediated degradation of Smad3 and Smad4 proteins respectively. Therefore, our results confirm that NS1 interacts with Smad proteins and reduces their expression by utilizing E3 ligase and disrupt the TGF-β/Smad signaling.
Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic nephropathy
Authors: Zhou Xue-hong , Liu Shu-yan , Feng Lin , Yang Bo , Li Yong-feng , Wang Xiao-qing , Chen Jie , Wang Hui-hui 
Published: October 2020

Abstract
Background:Diagnosing diabetic nephropathy is important to prevent long-term kidney damage and determine the prognosis of patients with diabetes. Since some kidney injury biomarkers increase in the early stages of diabetic nephropathy, this study investigated the clinical significance of combined detection of urine orosomucoid and retinol-binding protein for early diagnosis of diabetic nephropathy.Methods:We included 72 patients with type 2 diabetes and 34 healthy persons between August 2016 and July 2018 at our hospital. Using the Mogensen grading criteria, participants were classified as having diabetes or diabetic nephropathy, and healthy persons constituted the control group. Urine orosomucoid and retinol-binding protein levels were measured and correlated with other variables.Results:Increase in renal damage raised urinary orosomucoid levels gradually (P<0.05). Urinary retinol-binding protein and microalbumin levels were significantly higher in the diabetes group than in control and nephropathy groups. Orosomucoid and retinol-binding protein might be independent risk factors for diabetes and diabetic nephropathy. Urinary orosomucoid significantly correlated with retinol-binding protein and microalbumin levels (r = 0.489 and 0.513, respectively) in the diabetic nephropathy group. The receiver operating characteristic curve yielded a sensitivity, specificity, and correction index of 0.941, 0.842, and 0.783, respectively, while analysis for retinol-binding protein yielded a sensitivity, specificity, and correction index of 0.942, 1.000, and 0.941, respectively.Conclusion:The increase in urine orosomucoid and retinol-binding protein levels can be detected in the early stages of type 2 diabetic nephropathy. Therefore, both markers are important for diabetic nephropathy detection and early treatment.