bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asynchronous control of T‐S fuzzy chaotic systems via a unified model using the hidden Markov model subject to strict dissipativity
Authors: Xu Chuancan , Tong Dongbing , Chen Qiaoyu , Zhou Wuneng 
Published: December 2019

SummaryThe asynchronous control for the unified model of chaotic systems with Markovian jumping parameters is considered via the Takagi‐Sugeno (T‐S) fuzzy approach in this paper. According to jumping modes for chaotic systems and modes for the asynchronous controller, a double‐mode process is generated. By introducing the hidden Markov model (HMM), the asynchronization phenomenon is represented between the controller and chaotic systems. By linear matrix inequalities (LMIs), some conditions are received to guarantee the stochastic stability and the strict dissipativity for chaotic systems. Based on the stochastic stability theory and the dissipativity theory, the asynchronous controller is discussed. The proposed method can be applied to the mode‐independent controller and the synchronous controller. Finally, the effectiveness of the proposed controller is illustrated by two examples.
Fiber distribution of long fiber reinforced polyamide and effect of fiber orientation on mechanical behavior
Authors: Zhu Hanrui , Gu Yizhuo , Yang Zhongjia , Li Qinghui , Li Min , Wang Shaokai , Zhang Zuoguang 
Published: December 2019

AbstractThe objective of this paper is to research fiber distribution and mechanical behavior (tensile, flexural, and Charpy impact properties) of long fiber reinforced thermoplastic (LFT) plates made by injection molding. The plates were made of long glass fiber reinforced polyamide 6,6 granules and injected using two types of molds, including center‐gated and end‐gated injecting modes, to obtain different fiber orientation state. In addition, end‐gated plate was cut along three directions (0°/45°/90°) to main flow path, in order to experimentally investigate the effects of fiber orientation on mechanical properties. It is found that there is skin‐shell‐transition‐core structure across thickness of plate, resulted from different fiber orientation. Furthermore, end‐gated plate has more obvious fiber orientation at shell and core regions than center‐gated plate. The experimental results demonstrate that fiber orientation has significant effects on modulus, strength, toughness, and full‐field strain evolution. Tensile and flexural properties decrease by over 50%, as the cutting angle with respect to flow direction changes from 0° to 90° in end‐gated plate. Moreover, unnotched and notched strength drops by 66% and 33%, respectively, from 0° to 90° off‐axis angle. These results show apparent mechanical anisotropy of LFT. Shell‐core structure also significantly influences strain distribution and fracture morphology.
Understanding utilization patterns of biologics and biosimilars in the United States to support postmarketing studies of safety and effectiveness
Authors: Dutcher Sarah K. , Fazio‐Eynullayeva Elnara , Eworuke Efe , Carruth Amanda , Dee Elizabeth C. , Blum Michael D. , Nguyen Michael D. , Toh Sengwee , Panozzo Catherine A. , Lyons Jennifer G. 
Published: December 2019

AbstractPurposeTo describe utilization of filgrastim and infliximab, the first two products with biosimilars approved in the United States.MethodsWe identified use of filgrastim (reference, tbo‐filgrastim, and filgrastim‐sndz) and infliximab (reference, infliximab‐dyyb, and infliximab‐abda) in the Sentinel Distributed Database using Healthcare Common Procedure Coding System (HCPCS) codes and National Drug Codes (NDCs) from January 2015 to August 2018. We calculated the proportion of use by code type and assessed uptake over time. We compared baseline patient characteristics and treatment indications. Among patients with >1 exposure episode, we characterized gaps between episodes.ResultsUse was identified primarily via HCPCS codes (filgrastim: 86.4%‐97.7%; infliximab: 87.8%‐100%) although some was identified via NDCs (filgrastim: 2.2%‐13.5%; infliximab: <0.1%‐6.5%). Filgrastim reference product use declined from 89.4% in January 2015 to 30.3% in June 2018, with corresponding increases in filgrastim‐sndz (0% to 49.3%) and tbo‐filgrastim (10.6% to 20.4%). Infliximab biosimilar uptake was low (9.7% in June 2018). We identified 94 846 filgrastim reference product, 27 143 tbo‐filgrastim, and 38 264 filgrastim‐sndz users. For infliximab, we identified 125 412 reference product, 1034 infliximab‐dyyb, 49 infliximab‐abda, and 4855 undetermined biosimilar users. Patients receiving filgrastim products were largely similar, but differences in age, sex, and indication were observed across infliximab product users. The median exposure episode gap ranged from 1 to 3 days for filgrastim and 48 to 50 days for infliximab.ConclusionUse of biosimilar filgrastim has increased in the United States, but infliximab biosimilar use remains low. Data on identification of biosimilars in claims data and observed gaps between exposure episodes can be used to support drug safety studies of biosimilars.
The versatility of passivating carrier‐selective silicon thin films for diverse high‐efficiency screen‐printed heterojunction‐based solar cells
Authors: Descoeudres Antoine , Horzel Jörg , Paviet‐Salomon Bertrand , Senaud Laurie‐Lou , Christmann Gabriel , Geissbühler Jonas , Wyss Patrick , Badel Nicolas , Schüttauf Jan‐Willem , Zhao Jun , Allebé Christophe , Faes Antonin , Nicolay Sylvain , Ballif Christophe , Despeisse Matthieu 
Published: December 2019

AbstractProviding state‐of‐the‐art surface passivation and the required carrier selectivity for both contacts, hydrogenated amorphous silicon thin films are the key components of silicon heterojunction (SHJ) solar cells. After intensive optimization of these layers for standard front and back contacted (FBC) n‐type cells, high surface passivation levels were achieved on cell precursors, demonstrated by minority carrier lifetimes exceeding 18 ms on float‐zone (FZ) and 11 ms on Czochralski (Cz) c‐Si wafers. The application of these very same layers on cheaper and commercially available Cz p‐type wafers resulted in similar passivation quality, with lifetimes above 10 ms as well. Large‐area industrial bifacial FBC SHJ cells processed on wafers taken along the full length of a high‐resistivity Cz p‐type ingot showed efficiencies in the 22.5% to 23% range, significantly higher than previously reported results on such substrates and on par with their n‐type counterparts. Best efficiencies on large‐area monofacial devices (>220 cm2) are 23.6% on Cz p‐type and 24.4% on Cz n‐type, similar to certified results obtained on lab‐scale cells (4 cm2), 23.76% on FZ p‐type and 24.21% on FZ n‐type. Notably, no specific adaptation of the reference n‐type cell process was necessary to achieve these results on p‐type material. Additionally, a 25% certified efficiency has been obtained on medium‐sized (25 cm2) interdigitated back‐contacted SHJ cells, featuring the same passivation layers developed for FBC devices. These results illustrate the versatility of the SHJ technology for various high‐efficiency screen‐printed solar cell configurations and show possible ways to improve its competitiveness on the global photovoltaic market.
PDMS Microwell Stencil Based Multiplexed Single‐Cell Secretion Analysis
Authors: Liu Meimei , Jin Meihua , Li Linmei , Ji Yahui , Zhu Fengjiao , Luo Yong , Liu Tingjiao , Lin Bingcheng , Lu Yao 
Published: December 2019

AbstractMultiplexed single‐cell protein secretion analysis provides an in‐depth understanding of cellular heterogeneity in intercellular communications mediated by secreted proteins in both fundamental and clinical research. However, it has been challenging to increase the proteomic parameters co‐profiled from every single cell in a facile way. Herein, a simple method to improve the multiplexed proteomic parameters of PDMS microwell based single‐cell secretion analysis platform by sandwiching PDMS stencil in between two antibody‐coated glass slides is introduced. Two different antibody panels can be immobilized easily by static coating, without using sophisticated fluid handling or bulky equipment. 5‐plexed, 3‐fluorescence color single‐cell secretion assay is demonstrated with this platform to investigate human monocytic U937 cells in response to lipopolysaccharide and phorbol myristate acetate stimulation, which identified the existence of functional subsets dictated by different cytokine profiles. The technology introduced here is simple, easy to operate, which holds great potential to become a powerful tool for profiling multiplexed single‐cell cytokine secretion at high throughput to dissect cellular heterogeneity in secretome signatures.
Shedding light on the energetics, regioselectivity, stereoselectivity, and mechanistic aspects of [3 + 2] cycloaddition reaction between azomethine imines and 2‐sulfolene through molecular electron density theory
Authors: Babazadeh Sayyed Mohsen , Emamian Saeedreza 
Published: December 2019

AbstractIn the light of Molecular Electron Density Theory (MEDT), [3 + 2] cycloaddition (32CA) reaction between E‐azomethine imine (E‐AI‐2) and 2‐sulfolene (SF‐3) was explored at the M06‐2X/6‐31G(d,p) computational level. Calculated global reactivity indices classify E‐AI‐2 and SF‐3 as, respectively, a strong nucleophile and a moderate electrophile. The generation of cycloadduct CA‐2x, as the sole product, takes place along an irreversible pathway acting as the driving force to proceed such zwitterionic type (zw‐type) 32CA reaction. Analysis of the electrophilic and nucleophilic Parr functions, computed at the reactive sites of reactants, rationalizes the entirely N3‐C4 regioselectivity observed experimentally. Moreover, the exo‐stereoselectivity predominance is explained through non‐covalent interactions (NCIs) analysis over the two competitive exo TS‐2x and endo TS‐2n involved in the energetically more preferred regioselective pathway. An exploration of electron localization function (ELF) of the most relevant points located along the intrinsic reaction coordinate (IRC) profile of TS‐2x elucidates the molecular mechanism of the studied [3 + 2] cycloaddition reaction. Indeed, this reaction follows a nonconcerted two‐stage one‐step molecular mechanism providing two different patterns regarding carbon‐carbon (C–C) and carbon‐heteroatom (C–N) single bonds formation.
Testing treatment‐by‐period interaction in four‐period crossover trials
Authors: Li Bo , Zhou Zaiying , Zhang Li , Yang Ying 
Published: December 2019

Statistical analyses of crossover clinical trials have mainly focused on assessing the treatment effect, carryover effect, and period effect. When a treatment‐by‐period interaction is plausible, it is important to test such interaction first before making inferences on differences among individual treatments. Considerably less attention has been paid to the treatment‐by‐period interaction, which has historically been aliased with the carryover effect in two‐period or three‐period designs. In this article, from the data of a newly developed four‐period crossover design, we propose a statistical method to compare the effects of two active drugs with respect to two response variables. We study estimation and hypothesis testing considering the treatment‐by‐period interaction. Constrained least squares is used to estimate the treatment effect, period effect, and treatment‐by‐period interaction. For hypothesis testing, we extend a general multivariate method for analyzing the crossover design with multiple responses. Results from simulation studies have shown that this method performs very well. We also illustrate how to apply our method to the real data problem.
The influence of driving force on intramolecular electron transfer: A theoretical study of subphthalocyanine‐AzaBODIPY‐C60 supramolecular triad
Authors: Chen Wenlan , Chen Zhiqian , Zheng Shaohui 
Published: December 2019

AbstractThe driving force of electron transfer is one of important factors for initializing inter‐ and intramolecular charge separation. In this work, the main goal is to understand how driving force determines electron transfer pathway in subphthalocyanine‐AzaBODIPY‐C60 supramolecular triad. Experimental observations have suggested that there are only two intramolecular charge transfer states (subPC+‐AzaBODIPY−‐C60 and subPC+‐AzaBODIPY‐C60−) after photon absorption, where subPC is the donor. Through the calculations by using tuned long range corrected density functionals with polarizable continuum model, we find two more new intramolecular charge transfer states: subPC−‐AzaBODIPY+‐C60 and subPC‐AzaBODIPY+‐C60−, where AzaBODIPY is the donor. We compare the HOMO/LUMO energy of subPC, AzaBODIPY, and C60 monomers to their corresponding orbital energy in the triad. The results indicate that the driving force (HOMO/LUMO energy offsets) is not enough for electron transfer from AzaBODIPY to subPC or C60, which can explain why subPC−‐AzaBODIPY+‐C60 and subPC‐AzaBODIPY+‐C60− intramolecular charge transfer states cannot be observed in the experiment. In addition, this work may provide a simple and practical method to find the intramolecular charge transport pathway of a supramolecule.
Design and implementation of a new cable‐driven robot for MRI‐guided breast biopsy
Authors: Liu Wenxuan , Yang Zhiyong , Jiang Shan , Feng Di , Zhang Daguang 
Published: December 2019

AbstractBackgroundBreast cancer is one of the most common cancer diagnosed among US women. Early and accurate diagnosis using breast biopsy techniques is essential in detecting cancer.MethodsIn this paper, we present a new cable‐driven robot for MRI‐guided breast biopsy. A compact three degree‐of‐freedom (DOF) semi‐automated robot driven by ultrasonic motors is designed with non‐magnetic materials. Next, a novel insertion trajectory planning algorithm based on the breast holder that we created is proposed and designed, which can help radiologists locate the lesion and calculate the insertion trajectory. To improve the accuracy of insertion, kinematic analysis and accuracy compensation methods are introduced.ResultsAn experimental study based on image recognition and positioning is performed to validate the performance of the new robot. The results show that the mean position accuracy is 0.7 ± 0.04 mm.ConclusionsApplication of the new robot can improve breast biopsy accuracy and reduce surgery time.
Novel Biomass‐Derived Adsorbents Grafted Sodium Titanium Silicate with High Adsorption Capacity for Rb+ and Cs+ in the Brine
Authors: Ding Dong , Li Kexin , Fang Dezhen , Ye Xiushen , Hu Yaoqiang , Tan Xiaoli , Liu Haining , Wu Zhijian 
Published: December 2019

AbstractTwo biomass‐derived adsorbents (BCA@STS, CBCA@STS) modified with sodium titanium silicate (STS) were synthesized through a hydrothermal deposition method and tested to adsorb Rb+ and Cs+ from aqueous solution and brine. The BET characterization results showed that the adsorbents had mesoporous structures and excellent adsorption capacity for Rb+ and Cs+ with the maximum adsorption amounts as high as 2.07 mmol g−1 and 1.47 mmol g−1, respectively. XRD and XPS analyses of the adsorbents before and after adsorption revealed that the high adsorption capacity is attributed to the Na+ located in the adsorbents and ion exchange between Na+ and Rb+ or Cs+ is the key mechanism. The chemical composition of functional substance is the mixture of (HNa)O⋅SiO2⋅2TiO2⋅2H2O and Na2Ti3O7. The adsorption amounts increase with increasing of pH, and decrease with the increase of NaCl concentration due to the competitive adsorption between H+/Na+ and Rb+/Cs+. The adsorption kinetics of both these two adsorbents were well fitted to the pseudo‐second order kinetic model indicating that the chemisorption was dominant throughout the adsorption process. Apart from the excellent adsorption properties of Rb+ and Cs+ from aqueous solution, both BCA@STS and CBCA@STS can be used for the adsorption of Rb+ and Cs+ from the brine, and the maximum adsorption rate is up to almost 100%, showing promising application for extracting of Rb+ and Cs+.
Enhanced Ciprofloxacin Photodegradation of Visible‐Light‐Driven Z‐Scheme g‐C3N4/Bi2WO6 Nanocomposites and Interface Effect
Authors: Mao Jianan , Hong Bo , Wei Junqi , Xu Jingcai , Han Yanbing , Jin Hongxiao , Jin Dingfeng , Peng Xiaoling , Li Jing , Yang Yanting , Gong Jie , Ge Hongliang , Wang Xinqing 
Published: December 2019

AbstractPhotocatalytic g‐C3N4/Bi2WO6 nanocomposites were synthesized by solvothermal method and grind‐calcination method, and then the phases, microstructure, components and photodegradation to ciprofloxacin (CIP) were studied in detail. The surface area of g‐C3N4/Bi2WO6 nanocomposites decreases with the increasing g‐C3N4 content. Bi2WO6 nanoparticles prepared with solvothermal method present the smaller grain size and the higher effective interface with the similar components. The photocatalytic activity of g‐C3N4/Bi2WO6 nanocomposites is higher than those of pristine g‐C3N4 nanosheets and Bi2WO6 nanoparticles, which the optimized CIP removal percent reaches about 98% in 120 min under visible light irradiation. The Z‐scheme g‐C3N4/Bi2WO6 heterojunctions facilitate the effective separation and accumulation of photogenerated electrons at conduction band of g‐C3N4 and holes at valence band of Bi2WO6, resulting in hydroxyl and superoxide radicals for the redox of CIP. S‐CN‐40presents the highest CIP removal percent due to the effective heterogeneous interface and C–CN‐20 possesses the good application prospects in practice for the simple preparation process.
Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors
Authors: Loo Larry Sai Weng , Vethe Heidrun , Soetedjo Andreas Alvin Purnomo , Paulo Joao A. , Jasmen Joanita , Jackson Nicholas , Bjørlykke Yngvild , Valdez Ivan A. , Vaudel Marc , Barsnes Harald , Gygi Steven P. , Ræder Helge , Teo Adrian Kee Keong , Kulkarni Rohit N. 
Published: December 2019

Abstract
A comprehensive characterization of the molecular processes controlling cell fate decisions is essential to derive stable progenitors and terminally differentiated cells that are functional from human pluripotent stem cells (hPSCs). Here, we report the use of quantitative proteomics to describe early proteome adaptations during hPSC differentiation toward pancreatic progenitors. We report that the use of unbiased quantitative proteomics allows the simultaneous profiling of numerous proteins at multiple time points, and is a valuable tool to guide the discovery of signaling events and molecular signatures underlying cellular differentiation. We also monitored the activity level of pathways whose roles are pivotal in the early pancreas differentiation, including the Hippo signaling pathway. The quantitative proteomics data set provides insights into the dynamics of the global proteome during the transition of hPSCs from a pluripotent state toward pancreatic differentiation.
Comparative study of ZnCl2‐activated and steam‐activated carbons used in the anode of microbial fuel cells
Authors: Nguyen Dang‐Trang , Taguchi Kozo 
Published: December 2019

AbstractThe anode electrode plays a vital role in the performance of microbial fuel cells (MFCs) because it has the function of collecting electrons generated by microorganisms living in the anode chamber. In this letter, activated carbon papers fabricated based on ZnCl2‐activated carbon (ZAC) or steam‐activated carbon (SAC) were used as the anodic materials. Escherichia coli was used as an electrogenic bacterium in a two‐chamber MFC. This study compared the performance of ZAC and SAC in the anode. X concentrations (X = 10, 20, and 40 wt%) of ZAC or SAC in the anodes were investigated. The ZAC‐based anode outperformed the SAC‐based anode in terms of MFC‐generated power density. © 2019 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
The ghost of nativespeakerism: The case of teacher classroom introductions in transnational contexts
Authors: Zacharias Nugrahenny T. 
Published: December 2019

Although the field of TESOL has attempted to move beyond the essentialistic and simplified identity category of native and nonnative labels, the ideological domination of nativespeakerism continues to be one of the most deeply embedded discourses that many nonnative English speaker teachers (NNESTs) have drawn on when teaching outside their home countries. This article describes the effects of nativespeakerism on teacher classroom introductions (TCIs) of one NNEST who recently crossed borders from Indonesia to the United States, which I refer to as a transnational English teacher or a TET. I employ an autoethnography approach alongside Bakhtin’s (1984) conceptualization of the other to describe hidden narrative voices (Mizzi, 2010) in the process of constructing a viable professional identity in a transnational context. Ellis and Adams (2014) stated that “the stories of a particular life can provide a useful way of knowing about general human experience” (p. 255). The “particular life” experience I would like to explore through this article is my classroom introductions in two different contexts, Indonesia and the United States, mediated by three different student populations: Indonesian, international, and native English speaker (NES) students. My intention in bringing such a seemingly simple act as a teacher introduction into existing conversation on native/non‐native‐ness is to put forward an idea that for many TETs, the negotiation of NNEST identities starts even before they step into the classroom and this functions as “a form of argument” (Maclure, 1993, p. 12) to project the most viable teacher identity.
Mutations in the nucleotide‐binding domain of putative sterol importers Aus1 and Pdr11 selectively affect utilization of exogenous sterol species in yeast
Authors: Papay Marek , Klein Cornelia , Hapala Ivan , Petriskova Livia , Kuchler Karl , Valachovic Martin 
Published: December 2019

AbstractSterol uptake in the yeast Saccharomyces cerevisiae is mediated by two plasma membrane ATP‐binding cassette transporters, Aus1 and Pdr11. Their expression is regulated by oxygen and is triggered by anaerobic growth conditions. Under these conditions, internal ergosterol synthesis is arrested and utilization of exogenous sterol is vital for yeast cells. Here, we demonstrate that Aus1 is the major importer of non–yeast sterols, mammalian cholesterol, and plant sterols under anaerobic conditions. In contrast, uptake of yeast native sterol, ergosterol, is relatively low. This uptake could not be enhanced by overexpression of either of the transporters. Interestingly, overexpression of the minor importer Pdr11 resulted in a substantial import of non–yeast sterols. We show that mutation of the conserved residue in one of the ABC characteristic motifs—the H‐loop in Aus1 and Pdr11—lowered their ATPase activity. The residual activity was sufficient to import exogenous sterols and to preserve cell viability. Importantly, the reduction of sterol import was dramatic for mammalian cholesterol and plant sterols, whereas import of yeast ergosterol was decreased only slightly indicating substrate selectivity of the sterol utilization process.
A note on couette flow of nematic crystals according to the Ericksen–Leslie theory
Authors: Rickert Wilhelm , Vilchevskaya Elena N. , Müller Wolfgang H. 
Published: December 2019

AbstractIn order to model the flow of nematic crystals, the theoretical framework according to Ericksen and Leslie is applied. The essentials of the theory are compiled and then specialized to Couette flow. The profiles for linear velocity and orientation angle will be computed and, in particular, we shall also study the rise in temperature due to viscous dissipation, which is frequently ignored by mechanicians. Analytical and numerical solutions for the fields are derived for different boundary conditions and will subsequently be discussed.