bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of hazard analysis critical control point in liquor production
Authors: Yin Le-Bin , He Ping , Liu Ya-Li , Li Le-Le 
Published: September 2020

Abstract
In order to explore the hazard analysis critical control point (HACCP, an internationally recognized food safety detection system) effect on food quality in liquor production, affecting the liquor five hazards monitoring, determine the key point is under control and discusses the relevant follow-up work, determine the HACCP work-flow, and discusses the implementation of HACCP, faithfully record the production process, put forward the critical limits, and strict monitoring, ensure the safety of liquor products stability, provide a reference for liquor enterprise production management.
Effects of modified atmosphere packaging combined with tea polyphenol treatment on the quality of grass carp during cold storage
Authors: Li Wenjun , Wang Chao , Ju Jian , Liu Zhijie , Hu Yong , Li Dongsheng , Li Wei 
Published: September 2020

Abstract
In this study, the effect of tea polyphenols (TP) combined with modified atmosphere packaging on the quality change of Cri fish fillets in cold storage was studied, expecting to provide a new strategy for the biological preservation of fish fillets. Fresh fillets were packed in three different methods as follows: Sprayed in 0.5% tea polyphenols solution (CP group);Sprayed in 0.5% tea polyphenols combining 50% CO2 + 50% N2 modified atmosphere packaging (MAPC group);50% CO2 + 50% N2 modified atmosphere packaging (MAP group) and fresh filletsb was control group. All four groups were storaged at 0°C condition. Total bacterial count, TVB-N, TBA, K and pH were periodically assessed. The microscopic morphology of muscle tissue after 10 days cold storage was observed. After 10 d of cold storage, the TVC in the MAPC group (4.43±0.25 lg cfu/g) was obviously lower than that in the MAP group (5.04±0.65 lg cfu/g) or CP group (4.90±0.21 lg cfu/g), and even lower than that in the control group (6.14±0.17 lg cfu/g). The control group revealed the most obvious growth trend, increasing from 0.15±0.03 mg MDA/kg to 0.65±0.14mg MDA/kg, followed by MAP group (0.15±0.08 mg MDA/kg to 0.52±0.07mg MDA/kg), and CP group (0.13±0.05 mgMDA/kg to 0.47±0.03mg MDA/kg), and the last was the MAPC group with the minimum amplification (0.14±0.02 mg MDA/kg to 0.47±0.13 mg MDA/kg).Tea polyphenols combining with modified atmosphere packaging is a new strategy in maintaining the quality of crisped grass carp during cold storage.
Synthesis of a nonlinear control law with efficiency energy for the self-balancing two wheeled vehicle
Authors: Nguyen C X , Lukianov A D , Pham T D , Nguyen A D 
Published: September 2020

Abstract
In the paper, we present a method of synthesizing the controller with optimum energy for two-wheeled self-balancing vehicles, based on the multi-purpose consumption function. The authors select the multi-purpose consumption function based on the quasi-optimality and minimum of energy. The synthesis of control laws based on the analytical design of aggregated controllers (ADAR) with manifold of quasi-optimality. The results of the proposed method are simulated and compared to other methods.
Electrochemical performance of porous Ni–Cr–Mo–Cu alloys for hydrogen evolution reactions in alkali solution
Authors: Li Xide , Yang Junsheng , Feng Xindong , Hu Yangdon , Zou Haoran , Zhang Chuo , Xiong Lieqiang , Zheng Xiao , Liu Yuzuo 
Published: September 2020

Abstract
Porous Ni–Cr–Mo–Cu alloys were fabricated by an activation reaction sintering technique with Ni, Cr, Mo, and Cu element powders as raw materials. The phase constitutes, morphology, and hydrogen evolution mechanism of the electrode were characterized by x-ray diffraction, scanning electron microscopy, and x-ray photoelectron spectroscopy. The electrochemical characterization for hydrogen evolution reaction (HER) was investigated by cyclic voltammetry curves, electrochemical impedance spectroscopy, and linear sweep voltammetry. Different parameters, including Cr content, temperature, and solution concentration that affected electrocatalytic activity for HER were also considered. The results illustrated that porous Ni–Cr–Mo–Cu electrodes possessed excellent hydrogen evolution performance, and the Cr content within a certain range 15 ∼ 25 wt% improved hydrogen evolution catalytic activity. The surface roughness R

f
of porous 60 wt%Ni-25 wt%Cr-10 wt%Mo-5 wt%Cu alloy electrodes was 8718.4, and the electrochemical activation energy is determined to be 7.46 kJ∙mol−1, compared with 53.44 kJ∙mol−1 for porous 70 wt%Ni-15 wt%Cr-10 wt%Mo-5 wt%Cu alloy electrodes.
Augmented reality in scientific visualization and communications: a new dawn of looking at antibody interactions
Authors: Chan Kwok-Fong , Poh Jun-Jie , Wu Wei-Ling , Gan Samuel Ken-En 
Published: September 2020

ABSTRACT
The use of augmented reality (AR) in providing three-dimensional (3D) visual support and image depth have been applied in education, tourism, historical studies, and medical training. In research and development, there has been a slow but growing use of AR tools in chemical and drug discovery, but little has been implemented for whole 3D antibody structures (IgE, IgM, IgA, IgG, and IgD) and in communicating their interactions with the antigens or receptors in publications. Given that antibody interactions can vary significantly between different monoclonal antibodies, a convenient and easy to use 3D visualization can convey structural mechanisms clearer to readers, especially in how residues may interact with one another. While this was previously constrained to the use of stereo images on printed material or molecular visualization software on the computer, the revolution of smartphone and phablets now allows visualization of whole molecular structures on-the-go, allowing rotations, zooming in and out, and even animations without complex devices or the training of visual prowess. While not yet as versatile as molecular visualization software on the computer, such technology is an improvement from stereo-images and bridges the gap with molecular visualization tools. In this report, we discuss the use of AR and how they can be employed in the holistic view of antibodies and the future of the technology for better scientific communication.
The Lab Must Go On
Authors: Jackson Brian R , Genzen Jonathan R 
Published: September 2020

Abstract

Objectives
The clinical laboratory community has faced unprecedented challenges in responding to the coronavirus disease 2019 (COVID-19) pandemic. Long-held assumptions about laboratory management have been reconsidered in light of these new circumstances.

Methods
Experience during the first 6 months of the COVID-19 pandemic at a clinical reference laboratory was reviewed in the context of several commonly held management principles to assess their relevance to clinical laboratory operations during a crisis.

Results
Management and operational ideas regarding different modes of communication, physical proximity and interaction, operating under a fixed budget, and maintaining a breadth of laboratory service offerings have been challenged during the COVID-19 pandemic. The importance of putting people first, maintaining collaboration, and providing effective leadership and communication throughout an organization have been highlighted.

Conclusions
The collaborative activities of highly interdependent teams and individuals have helped the clinical laboratory community respond to society’s needs in the COVID-19 crisis. Not all laboratory management principles apply equally well in the course of an international respiratory pandemic. When navigating crises, leaders need to distinguish situational management principles from those that are universal.
A Cluster-based, Spatial-sampling Method for Assessing Household Healthcare Utilization Patterns in Resource-limited Settings
Authors: Yu Alexander T , Shakya Rajani , Adhikari Bikram , Tamrakar Dipesh , Vaidya Krista , Maples Stace , Date Kashmira , Bogoch Isaac I , Bern Caryn , Qamar Farah , Yousafzai Mohammad T , Garrett Denise O , Longley Ashley T , Hemlock Caitlin , Luby Stephen , Aiemjoy Kristen , Andrews Jason R 
Published: September 2020

AbstractBackgroundImplementation of population-based surveys is resource intensive and logistically demanding, especially in areas with rapidly changing demographics and incomplete or no enumeration of the underlying population and their residences. To remove the need for pre-enumeration and to simplify field logistics for the population healthcare utilization survey used for the Surveillance for Enteric Fever in Asia Project in Nepal, we incorporated a geographic information system–based geosurvey and field mapping system into a single-stage cluster sampling approach.MethodsA survey was administered to ascertain healthcare-seeking behavior in individuals with recent suspected enteric fever. Catchment areas were based on residential addresses of enteric fever patients using study facilities; clusters were randomly selected from digitally created grids using available satellite images and all households within clusters were offered enrollment. A tablet-compatible geosurvey and mapping system that allowed for data-syncing and use in areas without cellular data was created using the ArcGIS suite of software.ResultsBetween January 2017 and November 2018, we surveyed 25 521 households in Nepal (16 769 in urban Kathmandu and 8752 in periurban Kavrepalanchok), representing 84 202 individuals. Overall, the survey participation rate was 90.9%, with geographic heterogeneity in participation rates within each catchment area. Areas with higher average household wealth had lower participation rates.ConclusionA geographic information system–based geosurvey and field mapping system allowed creation of a virtual household map at the same time as survey administration, enabling a single-stage cluster sampling method to assess healthcare utilization in Nepal for the Surveillance for Enteric Fever in Asia Project . This system removed the need for pre-enumeration of households in sampling areas, simplified logistics and could be replicated in future community surveys.
Methodological and Reporting Quality of Noninferiority Randomized Controlled Trials Comparing Antibiotic Therapies: A Systematic Review
Authors: Bai Anthony D , Komorowski Adam S , Lo Carson K L , Tandon Pranav , Li Xena X , Mokashi Vaibhav , Cvetkovic Anna , Kay Vanessa R , Findlater Aidan , Liang Laurel , Loeb Mark , Mertz Dominik 
Published: September 2020

Abstract

Background
Antibiotic noninferiority randomized controlled trials (RCTs) are used for approval of new antibiotics and making changes to antibiotic prescribing in clinical practice. We conducted a systematic review to assess the methodological and reporting quality of antibiotic noninferiority RCTs.

Methods
We searched MEDLINE, Embase, the Cochrane Database of Systematic Reviews, and the Food and Drug Administration drug database from inception until November 22, 2019, for noninferiority RCTs comparing different systemic antibiotic therapies. Comparisons between antibiotic types, doses, administration routes, or durations were included. Methodological and reporting quality indicators were based on the Consolidated Standards of Reporting Trials reporting guidelines. Two independent reviewers extracted the data.

Results
The systematic review included 227 studies. Of these, 135 (59.5%) studies were supported by pharmaceutical industry. Only 83 (36.6%) studies provided a justification for the noninferiority margin. Reporting of both intention-to-treat (ITT) and per-protocol (PP) analyses were done in 165 (72.7%) studies. The conclusion was misleading in 34 (15.0%) studies. The studies funded by pharmaceutical industry were less likely to be stopped early because of logistical reasons (3.0% vs 19.1%; odds ratio [OR] = 0.13; 95% confidence interval [CI], .04–.37) and to show inconclusive results (11.1% vs 42.9%; OR = 0.17; 95% CI, .08–.33). The quality of studies decreased over time with respect to blinding, early stopping, reporting of ITT with PP analysis, and having misleading conclusions.

Conclusions
There is room for improvement in the methodology and reporting of antibiotic noninferiority trials. Quality can be improved across the entire spectrum from investigators, funding agencies, as well as during the peer-review process.
There is room for improvement in the methodology and reporting of antibiotic noninferiority trials including justification of noninferiority margin, reporting of intention-to-treat analysis with per-protocol analysis, and having conclusions that are concordant with study results.
Clinical Trials Registration PROSPERO registration number CRD42020165040.
Suboptimal Intermittent Preventive Treatment in Pregnancy (IPTp) is Associated With an Increased Risk of Submicroscopic Plasmodium falciparum Infection in Pregnant Women: A Prospective Cohort Study in Benin
Authors: Hounkonnou Cornélia P A , Ndam Nicaise Tuikue , Fievet Nadine , Accrombessi Manfred , Yovo Emmanuel , Mama Atikatou , Sossou Darius , Vianou Bertin , Massougbodji Achille , Briand Valérie , Cot Michel , Cottrell Gilles 
Published: September 2020

Abstract

Background
Harmful maternal and neonatal health outcomes result from malaria in pregnancy, the prevention of which primarily relies on intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP). The World Health Organization recommends IPTp-SP in sub-Saharan Africa, but implementation is highly heterogeneous and often suboptimal in terms of the number of doses and their timing. In this study, we assessed the impact of this heterogeneity on malaria in pregnancy, mainly with respect to submicroscopic Plasmodium falciparum infections.

Methods
We used data from 273 Beninese women followed throughout pregnancy. Screening for P. falciparum infections, using both microscopy-based and polymerase chain reaction (PCR)–based methods, was performed monthly, and information on IPTp-SP doses was collected. Gestational age was estimated by repeated ultrasound scans. Using a negative binomial model, we investigated the effect of IPTp-SP doses and timing after 17 weeks of gestation on the number of P. falciparum infections, focusing on submicroscopic infections detectable only by PCR.

Results
At least 2 IPTp-SP doses were taken by 77.3% of the women. The median gestational age at the first IPTp-SP dose was 22 weeks. A late first IPTp-SP dose (&gt;21.2 weeks) was marginally associated with an increased number of P. falciparum infections (adjusted incidence rate ratio [aIRR] = 1.3; P = .098). The number of IPTp-SP doses was not associated with the number of submicroscopic infections (aIRR = 1.2, P = .543).

Conclusions
A late first IPTp-SP dose failed to provide optimal protection against P. falciparum, especially submicroscopic infections. This highlights the need for a new antimalarial drug for IPTp that could be taken early in pregnancy.
Decreasing High-risk Exposures for Healthcare Workers Through Universal Masking and Universal Severe Acute Respiratory Syndrome Coronavirus 2 Testing on Entry to a Tertiary Care Facility
Authors: Walker Jeremey , Fleece Molly E , Griffin Russell L , Leal Sixto M , Alsip Jorge A , Stigler William S , Nafziger Sarah D , Marrazzo Jeanne M , Lee Rachael A 
Published: September 2020

Abstract
We describe the impact of universal masking and universal testing at admission on high-risk exposures to severe acute respiratory syndrome coronavirus 2 for healthcare workers. Universal masking decreased the rate of high-risk exposures per patient-day by 68%, and universal testing further decreased those exposures by 77%.
Influence of “protective” symbionts throughout the different steps of an aphid–parasitoid interaction
Authors: Sochard Corentin , Bellec Laura , Simon Jean-Christophe , Outreman Yannick 
Published: September 2020

AbstractMicrobial associates are widespread in insects, some conferring a protection to their hosts against natural enemies like parasitoids. These protective symbionts may affect the infection success of the parasitoid by modifying behavioral defenses of their hosts, the development success of the parasitoid by conferring a resistance against it or by altering life-history traits of the emerging parasitoids. Here, we assessed the effects of different protective bacterial symbionts on the entire sequence of the host-parasitoid interaction (i.e., from parasitoid attack to offspring emergence) between the pea aphid, Acyrthosiphon pisum, and its main parasitoid, Aphidius ervi and their impacts on the life-history traits of the emerging parasitoids. To test whether symbiont-mediated phenotypes were general or specific to particular aphid–symbiont associations, we considered several aphid lineages, each harboring a different strain of either Hamiltonella defensa or Regiella insecticola, two protective symbionts commonly found in aphids. We found that symbiont species and strains had a weak effect on the ability of aphids to defend themselves against the parasitic wasps during the attack and a strong effect on aphid resistance against parasitoid development. While parasitism resistance was mainly determined by symbionts, their effects on host defensive behaviors varied largely from one aphid–symbiont association to another. Also, the symbiotic status of the aphid individuals had no impact on the attack rate of the parasitic wasps, the parasitoid emergence rate from parasitized aphids nor the life-history traits of the emerging parasitoids. Overall, no correlations between symbiont effects on the different stages of the host–parasitoid interaction was observed, suggesting no trade-offs or positive associations between symbiont-mediated phenotypes. Our study highlights the need to consider various sequences of the host-parasitoid interaction to better assess the outcomes of protective symbioses and understand the ecological and evolutionary dynamics of insect–symbiont associations.
Staged management of cardiac disease and concomitant early lung cancer: a 20-year single-center experience
Authors: Tricard Jérémy , Milad Daniel , Chermat Anaëlle , Simard Serge , Lacasse Yves , Dagenais François , Conti Massimo 
Published: September 2020

Abstract

OBJECTIVES
The association of unstable heart disease and resectable lung cancer is rare. The impacts of staged management, cardiac surgery with cardiopulmonary bypass (CPB) versus angioplasty, on long-term survival and cancer recurrence remain debated. We report our experience using staged management.

METHODS
From 1997 to 2016, 107 patients were treated at the Quebec Heart and Lung Institute: 72 underwent cardiac surgery with CPB (group 1), 35 were treated with angioplasty (group 2), followed by oncological pulmonary resection.

RESULTS
Two postoperative deaths (3%) and 1 ischaemic heart complication (1%) were reported in group 1. One death (3%) was reported in group 2. Two-year overall survival was 82% (59/72) in group 1 and 80% (28/35) in group 2; 5-year overall survival was 62% (33/53) in group 1 and 63% (19/30) in group 2. Two-year disease-free survival in group 1 was 79% (57/72) and 77% (27/35) in group 2; 5-year disease-free survival was 58% (31/53) in group 1 and 60% (18/30) in group 2. The independent risk factors for death after thoracic surgery were transfusions (P = 0.004) and grade ≥3 complications (P = 0.034). Independent risk factors for recurrence included the cancer stage (P &lt; 0.001) and, paradoxically, a shorter delay between cardiac and lung procedures (P = 0.031).

CONCLUSIONS
When a staged management remains feasible after cardiac procedure, oncological outcomes of patients with cardiopathy and lung cancer are satisfactory. CPB does not seem to be deleterious. The delay between procedures should intuitively be as small as possible but not at the expense of good recovery after the cardiac procedure.
Prognostic impact of tumour spread through air space in radiological subsolid and pure solid lung adenocarcinoma
Authors: Zhong Yifan , Xu Yong , Deng Jiajun , Wang Tingting , Sun Xiwen , Chen Donglai , Wu Chunyan , Hou Likun , Xie Huikang , She Yunlang , Xie Dong , Chen Chang 
Published: September 2020

Abstract

OBJECTIVES
The aim of the study was to investigate the relationship between ground-glass opacity (GGO) and tumour spread through air space (STAS), as well as their joint influence on the prognosis of stage I lung adenocarcinoma.

METHODS
A total of 620 consecutive patients with surgically resected lung adenocarcinoma between January 2011 and December 2012 were reviewed retrospectively. The relevance of STAS and GGO was analysed by logistic regression, and their prognostic significance was investigated via the Kaplan–Meier method and Cox regression models. Furthermore, to determine the magnitude of the prognostic impact of GGO and STAS, we respectively performed survival analysis in subgroups according to the presence of STAS and GGO.

RESULTS
Of all 620 cases, 26.7% were positive for STAS, and 32.9% had a GGO component. STAS was present in 10.8% of part-solid lesions and 34.9% of pure solid nodules (P &lt; 0.001). Lepidic-predominant histologic subtype, GGO component and pathological T stage exhibited significant relevance to the presence of STAS. For the whole population, STAS and GGO component were each revealed as independent predictors for overall survival and recurrence-free survival (each with P &lt; 0.001). Interestingly, in the GGO-present subgroup, STAS failed to significantly stratify prognosis. However, in the STAS-positive subgroup, the presence of a GGO component was independently associated with favourable oncological results.

CONCLUSIONS
STAS is associated with a GGO component, and each factor was a significant predictor for the prognosis of stage I lung adenocarcinoma. Moreover, the favourable prognostic impact of a GGO component was greater than the adverse prognostic influence of STAS, indicating that GGO is a more reliable prognostic predictor in stage I lung adenocarcinoma.
Cohort Differences in Maximal Physical Performance: A Comparison of 75- and 80-Year-Old Men and Women Born 28 Years Apart
Authors: Koivunen Kaisa , Sillanpää Elina , Munukka Matti , Portegijs Erja , Rantanen Taina 
Published: September 2020

AbstractBackgroundWhether increased life expectancy is accompanied by increased functional capacity in older people at specific ages is unclear. We compared similar validated measures of maximal physical performance in 2 population-based older cohorts born and assessed 28 years apart.MethodParticipants in the first cohort were born in 1910 and 1914 and were assessed at age 75 and 80 years, respectively (N = 500, participation rate 77%). Participants in the second cohort were born in 1938 or 1939 and 1942 or 1943 and were assessed at age 75 and 80 years, respectively (N = 726, participation rate 40%). Participants were recruited using a population register and all community-dwelling persons in the target area were eligible. Both cohorts were interviewed at home and were examined at the research center with identical protocols. Maximal walking speed, maximal isometric grip and knee extension strength, forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) were assessed. Data on non-participation were systematically collected.ResultsWalking speed was on average 0.2–0.4 m/s faster in the later than earlier cohort. In grip strength, the improvements were 5%–25%, and in knee extension strength 20%–47%. In FVC, the improvements were 14–21% and in FEV1, 0–14%.ConclusionsThe later cohort showed markedly and meaningfully higher results in the maximal functional capacity tests, suggesting that currently 75- and 80-year-old people in Finland are living to older ages nowadays with better physical functioning.