bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desain dan Analisis Kehandalan Pipa Bawah Laut Pada Kondisi Instalasi Akibat Keacakan Tinggi Gelombang dan Kuat Leleh Baja
Authors: Ibrahim Andika Razandi , Paramashanti Paramashanti 
Published: October 2019

Demi mencapai metoda distribusi migas yang efisien, pipa bawah laut harus didesain agar dapat memenuhi tujuan desain selama masa layan. Pada proses desain digunakan data deterministic berupa tinggi gelombang signifikan dan kuat leleh baja desain. Pada studi ini proses desain dilakukan sesuai dengan standar DNV OS F101 dan DNV RP E305 untuk pipa dengan diameter 32 inci. Pada kondisi aktual saat proses instalasi, pipa mengalami tegangan yang diakibatkan oleh gelombang acak. Serta nilai desain kuat leleh baja yang digunakan merupakan hasil pengolahan dari banyak data acak uji tarik sampel baja. Oleh karena itu dilakukan analisis kehandalan menggunakan simulasi Monte Carlo untuk mengetahui efek dari keacakan tinggi gelombang dan kuat leleh baja terhadap tegangan yang terjadi disepanjang pipa. Simulasi Monte Carlo dilakukan sebanyak 100 simulasi untuk 3 (tiga) arah datang gelombang. Pada proses analisis kehandalan, pipa dianggap gagal apabila nilai tegangan total maksimum yang terjadi lebih besar atau sama dengan nilai kuat leleh. Berdasarkan hasil simulasi didapat kesimpulan bahwa pipa dinyatakan tidak handal karena memiliki nilai probabilitas kehandalan kurang dari 0.998. In order to achieve an efficient oil and gas distribution method, subsea pipelines must be designed to meet design goals during service life. In term of design process, deterministic data used in form of significant wave height and steel yield strength. In this study, the design process carried out according to DNV OS F101 and DNV RP E305 standards for pipeline with 32 inches outer diameter. In actual conditions during the installation process, tensions applied along the pipeline as effect from random waves. Also the design value of design steel yield strength is a result from many random tensile test value of steel samples. Therefore, reliability analysis carried out using Monte Carlo simulation to determine the effect of random wave heights and steel yield strengths on the stress occurred along pipeline. Monte Carlo simulation are carried out as many as 100 simulations for each of three wave headings. In reliability analysis, pipeline is considered fail if the maximum total stress that occurs is greater or equal to its yield strength. Based on the simulation results, pipeline considered unreliable due to its reliability probability value which is lower than 0.998.
A short note on Helmholtz decompositions for bounded domains in $\mathbb{R}^3$
Authors: Anjam Immanuel 
Published: October 2019

In this short note we consider several widely used $\mathsf {L}^{2}$-orthogonal Helmholtz decompositions for bounded domains in $\mathbb {R}^3$. It is well known that one part of the decompositions is a subspace of the space of functions with zero mean. We refine this global property into a local equivalent: we show that functions from these spaces have zero mean in every subdomain of specific decompositions of the domain.
An application of the zero mean properties is presented for convex domains. We introduce a specialized Poincaré-type inequality, and estimate the related unknown constant from above. The upper bound is derived using the upper bound for the Poincaré constant proven by Payne and Weinberger. This is then used to obtain a small improvement of upper bounds of two Maxwell-type constants originally proven by Pauly.
Although the two dimensional case is not considered, all derived results can be repeated in $\mathbb {R}^2$ by similar calculations.
Switchable Adhesion of Hydrogels to Plant and Animal Tissues
Authors: Borden Leah K. , Nader Morine G. , Burni Faraz A. , Grasso Samantha M. , Orueta‐Ortega Irene , Srivastava Mahima , Montero‐Atienza Paula , Erdi Metecan , Wright Sarah L. , Sarkar Rajabrata , Sandler Anthony D. , Raghavan Srinivasa R. 
Published: December 2024

AbstractThe ability to “switch on” adhesion between a thin hydrogel and a biological tissue can be useful in biomedical applications such as surgery. One way to accomplish this is with an electric field, a phenomenon termed electroadhesion (EA). Here, it is shown that cationic gels can be adhered by EA to tissues across all of biology. This includes tissues from animals, including humans and other mammals; birds; fish; reptiles (e.g., lizards); amphibians (e.g., frogs), and invertebrates (e.g., shrimp, worms). Gels can also be adhered to soft tissues from plants, including fruit (e.g., plums) and vegetables (e.g; carrot). In all cases, EA is induced by a low electric field (DC, 10 V) applied for a short time (20 s). After the field is removed, the adhesion persists. The adhesion can also be reversed by applying the field with opposite polarity. In mammals, EA is strong for many tissues (e.g., arteries, muscles, and cornea), but not others (e.g., adipose, brain). Tissues with anisotropic structure show anisotropic adhesion strength by EA. The higher the concentration of anionic polymers in a tissue, the stronger its adhesion to cationic gels. This underscores that EA is mediated by the electrophoresis of chain segments across the gel‐tissue interface.
Temporally resolved concentration profiling via computationally limited, distributed sensor nodes
Authors: Manion Matthew Lee , Doctor Joshua , Liu Albert Tianxiang 
Published: December 2024

AbstractAccurate mapping of chemical concentrations in reactor networks remains an obstacle to establish complete systems‐level insight and control. This issue extends beyond traditional reactor design to biological and other inaccessible systems of interest. Recent developments in novel materials with non‐volatile memory allow autonomous sensor nodes to record information with minimal external supervision. Integrating these materials in solution suspended particles demonstrates the unique potential for diffuse measurements of chemical data at the microscale. In this study, we establish a generalized workflow for the simulated deployment of time aware particle sensors (TAPS) in ideal reactor systems to measure analyte profiles, using Gillespie kinetic Monte Carlo algorithms (KMC). Our results show that computationally‐limited, chemically sensitive tracer particles capable of timestamping an analyte detection event can provide accurate analyte profiles throughout multistage reactors in an ensemble fashion.
Inhibition of Bone Morphogenetic Protein Signaling Prevents Tau Pathology in iPSC Derived Neurons and PS19 Mice
Authors: Affaneh Amira , Linden Anne K. , Tunc‐Ozcan Elif , Tsai Yung‐Hsu , Peng Chian‐Yu , Kessler John A. 
Published: December 2024

ObjectiveMany neurodegenerative disorders share a common pathologic feature involving the deposition of abnormal tau protein in the brain (tauopathies). This suggests that there may be some shared pathophysiologic mechanism(s). The largest risk factor for the majority of these disorders is aging, suggesting involvement of the aging process in the shared pathophysiology. We test the hypothesis that an increase in bone morphogenetic protein (BMP) signaling that occurs during aging contributes to the onset and progression of tauopathies.MethodsHuman induced pluripotent stem cell (iPSC)‐derived neurons from patients with Alzheimer's disease (AD) were used to investigate the effects of BMP signaling on tau phosphorylation and release and the mechanisms underlying these effects. Wildtype mice were used to examine effects of BMP signaling in vivo. P301S (PS19) mice were examined for the effects of BMP signaling in a model of tauopathy.ResultsHere, we show that BMP signaling, mediated by non‐canonical p38 signaling, increases tau phosphorylation and release of p‐tau in human iPSC‐derived AD neurons. Further, there is an interaction between BMP signaling and apolipoprotein E4 (ApoE4) that significantly increases tau phosphorylation and release compared with ApoE3 neurons. Inhibiting BMP signaling reduces the changes in tau in the cultured human neurons, and it limits tau pathology and prevents cognitive decline in PS19 mice.InterpretationOur study suggests that the age‐related increase in BMP signaling may participate in the onset and progression of tau pathology. Thus, therapeutic interventions that reduce BMP signaling in the aging brain could potentially slow or prevent development of diseases involving tau hyperphosphorylation. ANN NEUROL 2024
Integrative Molekulardynamiksimulationen entwirren cross‐linking Daten und zeigen Verteilungen von mitochondrialen Proteinen
Authors: Schuhmann Fabian , Akkaya Kerem Can , Puchkov Dmytro , Hohensee Svea , Lehmann Martin , Liu Fan , Pezeshkian Weria 
Published: December 2024

AbstractDurch Cross‐Linking‐Massenspektrometrie (XL‐MS) wird die Quantifizierung von Protein‐Protein‐Interaktionen auf zellulärer Ebene ermöglicht. Werden alle Teile eines Mitrochondrions analysiert, kann die schiere Anzahl der Verbindungen eine einfache Clusteranalyse unübersichtlich und uninformatif machen. Um diesem Hindernis zu begegnen, verbinden wir die XL‐MS‐Daten, Daten aus der 3D‐Elektronenmikroskopiedaten und Lokalisierungsannotationen mit einer grobkörnige Molekulardynamiksimulation. Auf diese Weise lassen sich alle Daten sortieren und die Cluster besser zugänglich und interpretierbar machen. Im Falle von Mitochondrien identifiziert diese Methode mit Hilfe von insgesamt 6,9 Millisekunden langen Simulationen erfolgreich bekannte und unbekannte Proteincluster und zeigt die Verteilung der inneren mitochondrialen Membranproteine auf, was eine genauere Lokalisierung innerhalb der einzelnen Segmente ermöglicht. Unser integrativer Ansatz legt nahe, dass zwei bisher nicht eindeutig lokalisierte Proteine FAM162A und TMEM126A in der Cristae angesiedelt sind. Dies wird durch hochauflösende Mikroskopie bestätigt. Zusammengenommen, zeigt dies das große Potenzial des vorgestellten Ansatzes.
A Highly Active Molybdenum Carbide Catalyst with Dynamic Carbon Flux for Reverse Water‐Gas Shift Reaction
Authors: Zhang Mengtao , Zhu Yuchen , Yan Jie , Xie Junzhong , Yu Tao , Peng Mi , Zhao Jiayun , Xu Yao , Li Aowen , Jia ChunJiang , He Lin , Wang Meng , Zhou Wu , Wang Rongming , Jiang Hong , Shi Chuan , Rodriguez Jose , Ma Ding 
Published: December 2024

AbstractMolybdenum carbide has been reported as an efficient and stable catalyst for reverse water‐gas shift (RWGS) reaction. The conventional understanding of the mechanism suggests domination of the surface phenomena, with only surface or subsurface layers partaking in the catalytic cycle. In this study, we presented a highly active MoC catalyst from carburization process, which showed a mass‐specific reaction rate over 260 μm
with dynamic carbon flux in the bulk phase of the catalyst. Through Isotopic Temperature‐Programmed Reaction (ITPR) analysis and Environmental Transmission Electron Microscopy (ETEM), we discerned dynamic carbon flow circulating between the α‐MoC bulk phase and the gas phase reactants under the RWGS reaction atmosphere. This circulation, essential to maintaining the structural stability of the metastable α‐MoC and its ultra‐high reactivity, is accompanied by thorough carbon component exchange among the bulk, the surface and the gas‐phase reactants during the reaction process.
Heterochiral Self‐Discrimination Driven Dimerization of Polynuclear Gold(I)‐Sulfido Complexes with Enhanced Phosphorescence
Authors: Yan Liang‐Liang , Chen Ziyong , Yam Vivian Wing‐Wah 
Published: December 2024

AbstractDecanuclear chiral gold(I) sulfido clusters (SSDP‐Au10 and RSDP‐Au10) have been assembled by taking advantage of the judiciously selected SDP ligands (SDP = 7,7′‐bis(diphenylphosphino)‐1,1′‐spirobiindane). Interestingly, an achiral heterodimer icosanuclear meso‐cluster (mesoSDP‐Au20) has been obtained by simply mixing SSDP‐Au10 and RSDP‐Au10 in a 1:1 ratio. These gold(I) complexes have been found to display intense near‐infrared (NIR) luminescence with an emission maximum at around 750 nm in the solid state. The photoluminescence quantum yield (PLQY) of mesoSDP‐Au20 in drop‐cast solid‐state thin film has been found to show a significant enhancement from 8 % in the SSDP‐Au10 and RSDP‐Au10 to 25 %. In addition, the dimerization process with heterochiral self‐discrimination has been found to be sensitive to the solvent polarity and configuration of the diphosphine ligand. This work has provided a platform for the investigation and mechanistic understanding of heterochiral self‐sorting and assembly processes.
Integrative Molecular Dynamics Simulations Untangle Cross‐Linking Data to Unveil Mitochondrial Protein Distributions
Authors: Schuhmann Fabian , Akkaya Kerem Can , Puchkov Dmytro , Hohensee Svea , Lehmann Martin , Liu Fan , Pezeshkian Weria 
Published: December 2024

AbstractCross‐linking mass spectrometry (XL‐MS) enables the mapping of protein‐protein interactions on the cellular level. When applied to all compartments of mitochondria, the sheer number of cross‐links and connections can be overwhelming, rendering simple cluster analyses convoluted and uninformative. To address this limitation, we integrate the XL‐MS data, 3D electron microscopy data, and localization annotations with a supra coarse‐grained molecular dynamics simulation to sort all data, making clusters more accessible and interpretable. In the context of mitochondria, this method, through a total of 6.9 milliseconds of simulations, successfully identifies known, suggests unknown protein clusters, and reveals the distribution of inner mitochondrial membrane proteins allowing a more precise localization within compartments. Our integrative approach suggests, that two so‐far ambigiously placed proteins FAM162A and TMEM126A are localized in the cristae, which is validated through super resolution microscopy. Together, this demonstrates the strong potential of the presented approach.
Cell‐Specific Control of Mammalian Gene Expression Using DNA Repair Inducible Ribozyme Switches
Authors: Hong Jieling , Jiang Zhen , Wu Zhenkun , Jiang Jian‐Hui 
Published: December 2024

AbstractThe ability to control gene expression is vital for elucidating gene functions and developing next‐generation therapeutics. Current techniques are challenged by the lack of cell‐specific control designs or immunogenicity risk from foreign proteins. We develop a DNA repair inducible ribozyme switch that enables cell‐specific control of gene expression in cells and in vivo. This strategy designs plasmids with a DNA lesion (8‐oxoG and O6‐MeG) site‐specifically installed within the ribozyme encoding region, generating active hammerhead ribozyme for mRNA degradation due to transcriptional mutagenesis, whereas DNA repair yields a single‐base mismatch in the ribozyme to abrogate its activity. This strategy is demonstrated to allow specific control of gene expression in cancer cells with overexpressed DNA repair enzymes such as MutY DNA glycosylase and O6‐methylguanine‐DNA‐methyltransferases. It also shows the capability of conditionally regulating the expression of different proteins for signal reporting and gene editing, enabling DNA repair monitoring and targeted gene therapy in cancer cells. This strategy is demonstrated using the inducible CRISPR/Cas9 system for in vivo editing of oncogenic Polo‐like kinase 1 in a mouse model, resulting in significant tumor growth suppression. The DNA repair inducible ribozyme switch may provide a compact system for cell‐specific gene expression control toward precise gene therapy.
Radial Metallicity Gradients for the Chemically Selected Galactic Thin Disc Main‐Sequence Stars
Authors: Akbaba F. , Ak T. , Bilir S. , Plevne O. , Önal Taş Ö. , Seabroke G. M. 
Published: December 2024

ABSTRACTWe present the radial metallicity gradients within the Galactic thin disc population through main‐sequence stars selected on the chemical plane using GALAH DR3 accompanied with Gaia DR3 astrometric data. The [Fe/H], [/Fe] and [Mg/H] radial gradients are estimated for guiding radius as , , dex kpc and for the traceback early orbital radius as , , dex kpc for 66,545 thin‐disc stars, respectively. Alteration of the chemical structure within the Galactic disc caused by the radial orbital variations complicates results for the radial metallicity gradient. The effect of radial orbital variations on the metallicity gradients as a function on time indicates the following results: (i) The presence of a gradient along the disc throughout the time for which the model provides similar prediction, (ii) the radial orbital variations becomes more pronounced with the age of the stellar population and (iii) the effect of radial orbital variations on the metallicity gradients is minimal. The effect of radial orbital variations is found to be at most 6% which does not statistically affect the radial gradient results. These findings contribute to a better understanding of the chemical evolution within the Galactic disc and provide an important basis for further research.
Remote monitoring of social attention in neurogenetic syndromes and idiopathic neurodevelopmental disability
Authors: Frazier Thomas W. , Busch Robyn M. , Klaas Patricia , Lachlan Katherine , Jeste Shafali , Kolevzon Alexander , Loth Eva , Harris Jacqueline , Pepper Tom , Anthony Kristin , Graglia J. Michael , Helde Kathryn , Delagrammatikas Christal , Bedrosian‐Sermone Sandra , Smith‐Hicks Constance , Sahin Mustafa , Youngstrom Eric A. , Eng Charis , Chetcuti Lacey , Hardan Antonio Y. , Uljarevic Mirko 
Published: December 2024

AbstractSocial attention is a key aspect of neurodevelopment and is significantly altered in neurodevelopmental genetic syndromes and many individuals with idiopathic autism spectrum disorder (ASD). The primary aim of the present study was to examine the psychometric properties of webcam‐collected social attention measurements, including four new specific aspects of social attention, in three genetic syndromes (PTEN Hamartoma Tumor Syndrome—PHTS; Malan Syndrome—NFIX; and SYNGAP1‐related disorder—SYNGAP1), a mixed group of other neurodevelopmental genetic syndromes (Other NDGS), and individuals with a range of idiopathic neurodevelopmental disorder (NDD). The secondary aim was to evaluate the construct validity of these social attention measurements, including evaluating known‐groups validity across study groups and concurrent validity for separating ASD and non‐ASD cases. Participants (N = 467, age 3–45; PHTS n = 102, NFIX n = 23, SYNGAP1 n = 42, other NDGS n = 63, idiopathic NDD n = 53, neurotypical siblings n = 71, and unrelated neurotypical controls n = 113) completed a 4‐min online‐administered social attention paradigm that includes a variety of distinct stimuli at three timepoints (baseline, 1‐month, and 4‐month follow‐up). Social attention measures had good scale and test–retest reliability, with the exception of measures of non‐social preference and face‐specific processing. Unique patterns of social attention emerged across study groups, with near neurotypical levels in PHTS and weaker social attention in NFIX and SYNGAP1 relative to controls. Global social attention had good accuracy in detecting ASD within NDGS participants. Remote monitoring social attention, including distinct aspects of social attention, may be useful for characterizing phenotypic profiles and tracking the natural history of distinct NDGS and idiopathic NDD as well as identifying ASD within NDGS. Given their reproducibility and stability, global social attention and several distinct social attention measures may be useful outcomes for future clinical trials.
Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients
Authors: Yeh En‐Ling , Yang Chun‐Pai , Lin Shu‐Wen , Wang Hsueh‐Fang 
Published: December 2024

ABSTRACTObjectivesMigraine is a chronic, recurring, and disabling disease. Fish oil intervention was used to investigate its effects on headache symptoms and blood lipids of migraine patients.DesignAll subjects were collected at the Kuang Tian General Hospital from March 2020 to May 2021. Experimental group subjects took 1 g/time of fish oil (including EPA 900 mg/tablet) after breakfast and dinner. Placebo group subjects took 100% soybean oil twice daily. Before and after the test, the migraine improvement questionnaire was used to analyze headaches during attacks, dietary intake, and headache triggers.ResultsThe average age of the 47 subjects in this study was 40.3 ± 9.2 years old, the body mass index (BMI) was 24.3 ± 6.0 kg/m2. At Week 12, subjects in the fish oil group were significantly improved relative to the control group (p < 0.05). Blood lipid indexes TC, LDL‐C, and TG were reduced, and the frequency, duration, and pain degree of migraine.ConclusionFish oil may be used as an adjunctive therapeutic food for relieving migraine attack symptoms and blood lipids.
Exploring the Causal Relationship Between Inflammatory Cytokines and MRI‐Derived Brain Iron: A Mendelian Randomization Study
Authors: Wu Zhounan , Xu Wantong , Wang Xuemei , Peng Dan , Jiang Zhongbiao 
Published: December 2024

ABSTRACTBackgroundThe association between inflammation and brain iron deposition is widely acknowledged. However, the precise causal impact of peripheral inflammatory cytokines on changes in brain iron content remains uncertain.MethodsThe study utilized an available genome‐wide association study (GWAS) summary associated with inflammatory cytokines from The Cardiovascular Risk in Young Finns Study and the FINRISK surveys. The GWAS data for brain iron markers were obtained from the UK Biobank. We assessed the iron content of each brain region using susceptibility‐weighted magnetic resonance imaging, utilizing both quantitative susceptibility mapping and T2* measurements. The primary outcomes were susceptibility (χ) and T2*, which serve as indices of iron deposition. To investigate the causal relationship between exposure and outcome, we primarily employed inverse variance weighting, MR Egger, weighted median, simple mode, and weighted mode methods, collectively enhancing the robustness of our results.ResultsThe results of MR analyses demonstrate that our study unveiled that nerve growth factor‐β, hepatocyte growth factor, interleukin‐1 (IL‐1), IL‐8, macrophage inflammatory protein 1α, and tumor necrosis factor‐α were associated with elevated brain iron content in the regions of left hippocampus, putamen, left thalamus, right pallidum, right hippocampus, left amygdala, respectively. Furthermore, our investigation provides evidence for a negative relationship between IL‐1, IL‐17, monocyte chemotactic protein‐3, tumor necrosis factor‐β, and brain iron content in distinct regions.ConclusionsOur findings suggest a causal association between circulating inflammatory cytokines and brain iron deposition across various brain regions. This provides new insights into the immunopathogenesis of neurodegenerative diseases and potential preventive strategies targeting iron metabolism.