bluuebunny/crossref_metadata_2025_split huggingface dataset:
International survey of COVID-19 management strategies
Authors: Tartaglia Riccardo , La Regina Micaela , Tanzini Michela , Pomare Chiara , Urwin Rachel , Ellis Louise A , Fineschi Vittorio , Venneri Francesco , Seghieri Chiara , Lachman Peter , Westbrook Johanna , Braithwaite Jeffrey 
Published: October 2020

Abstract

Background
While individual countries have gained considerable knowledge and experience in coronavirus disease of 2019 (COVID-19) management, an international, comparative perspective is lacking, particularly regarding the measures taken by different countries to tackle the pandemic. This paper elicits the views of health system staff, tapping into their personal expertise on how the pandemic was initially handled.

Methods
From May to July 2020, we conducted a cross-sectional, online, purpose-designed survey comprising 70 items. Email lists of contacts provided by the International Society for Quality in Health Care, the Italian Network for Safety in Health Care and the Australian Institute of Health Innovation were used to access healthcare professionals and managers across the world. We snowballed the survey to individuals and groups connected to these organizations. Key outcome measures were attitudes and information about institutional approaches taken; media communication; how acute hospitals were re-organized; primary health organization; personal protective equipment; and staffing and training.

Results
A total of 1131 survey participants from 97 countries across the World Health Organization (WHO) regions responded to the survey. Responses were from all six WHO regions; 57.9% were female and the majority had 10 or more years of experience in healthcare; almost half (46.5%) were physicians; and all other major clinical professional groups participated. As the pandemic progressed, most countries established an emergency task force, developed communication channels to citizens, organized health services to cope and put in place appropriate measures (e.g. pathways for COVID-19 patients, and testing, screening and tracing procedures). Some countries did this better than others. We found several significant differences between the WHO regions in how they are tackling the pandemic. For instance, while overall most respondents (71.4%) believed that there was an effective plan prior to the outbreak, this was only the case for 31.9% of respondents from the Pan American Health Organization compared with 90.7% of respondents from the South-East Asia Region (SEARO). Issues with swab testing (e.g. delay in communicating the swab outcome) were less frequently reported by respondents from SEARO and the Western Pacific Region compared with other regions.

Conclusion
The world has progressed in its knowledge and sophistication in tackling the pandemic after early and often substantial obstacles were encountered. Most WHO regions have or are in the process of responding well, although some countries have not yet instituted widespread measures known to support mitigation, for example, effective swab testing and social control measures.
Antimicrobial stewardship in Australian hospitals: how does compliance with antimicrobial stewardship standards compare across key hospital classifications?
Authors: Jones Renee , Carville Kylie , James Rodney 
Published: October 2020

AbstractBackgroundThere is little information on the prevalence and type of antimicrobial stewardship (AMS) activities that are currently occurring in Australian hospitals.ObjectivesTo determine what AMS activities are currently occurring in Australian hospitals, identify gaps in compliance with the Australian Commission on Safety and Quality in Health Care (ACSQHC) standards and determine perceived barriers and enablers for implementing AMS programmes.MethodsA cross-sectional survey open to all Australian hospitals, conducted online and available to hospitals between November 2016 and July 2017.ResultsResponses were received from 254 hospitals. Compliance with ACSQHC AMS essential activities was high, except for essential activity 3 (post-prescription reviews), which was conducted by only 39% of respondent hospitals. Importantly, compliance varied by hospital remoteness classification for all activities except essential activity 1 (availability and endorsement of guidelines) and additional activity 4 (publishing antimicrobial susceptibility data annually), with major city hospitals having the highest compliance across all activities. The three most frequently reported barriers to implementing AMS programmes were a lack of training and education, lack of pharmacy resources and a lack of willingness from medical officers to change.ConclusionsDue to low response rates from certain hospital groups, the survey results are not generalizable to all Australia hospitals. This survey has identified that several gaps in compliance still exist and outlines the need to address lower AMS compliance in hospitals located outside major cities. The key barriers and enablers for AMS programme implementation identified should be used to inform future strategies.
Evaluation of Infectious Disease Test Ordering and Positivity Rates in Illicit Fentanyl Users
Authors: Lloyd Matthew , Ransom Eric M , Anderson Neil W , Farnsworth Christopher W 
Published: October 2020

Abstract

Background
The emergence of illicit fentanyl use has resulted in considerable morbidity and mortality. Although illicit use of other opioids has been associated with transmission of viral and bacterial infections, limited data exist for the prevalence of infectious diseases among illicit fentanyl users. The purpose of this study was to assess the likelihood of infectious disease testing and infection prevalence among illicit fentanyl users.

Methods
Results from urine drug screens (UDSs) performed from August 13, 2019, to October 16, 2019, were obtained from the laboratory information system with concurrent microbial testing. Patients were categorized based on UDS results, and illicit drug use was inferred from physician encounter notes in the electronic medical record.

Results
Suspected illicit drugs users with fentanyl detected by UDS were more likely to be screened [odds ratio (OR): 1.7; 95% CI, 1.26–2.4] and test positive for hepatitis C virus (HCV) by immunoassay (OR: 5.89; 95% CI, 2.93–11.31) than patients without drugs detected. Patients with suspected illicit fentanyl use who were discharged from the emergency department (ED) were less likely to be tested for HCV than patients in outpatient settings (OR: 3.47; 95% CI, 1.05–10.4) and inpatient settings (OR: 17.43; 95% CI, 6.53–45.88). Patients with suspected illicit fentanyl use were more likely to have infected abscesses or wounds (OR: 5.12; 95% CI, 2.07–13.7) and Staphylococcus aureus infections (OR: 4.5; 95% CI, 1.59–12.28) than patients without drugs detected.

Conclusions
Patients with a positive UDS for fentanyl and suspected illicit use were more likely to test positive for HCV, were rarely screened for HCV in the ED, and had an increased risk of invasive S. aureus wound or abscess infection. These findings may represent considerable barriers to care for patients who use fentanyl illicitly.
Control Charting Genomic Data
Authors: Xu Jing , Crossley Eric , Wagenfuehr Jennifer , Mitui Midori , Londin Eric , Patel Khushbu , Park Jason Y 
Published: October 2020

Abstract

Background
Control charting is routine in the quality assurance of traditional clinical laboratory testing. Genomic tests are not typically managed by control charting. We examined control charting to monitor the performance of a clinical next-generation sequencing (NGS) assay.

Methods
We retrospectively examined 3 years of control material (NA12878) data from clinical genomic epilepsy testing. Levey-Jennings plots were used to visualize changes in control material depth of sequencing coverage in genomic regions of an epilepsy genomic panel. Changes in depth of coverage were correlated with changes in the manufactured lot of capture probe reagent. Depth of coverage was also correlated between quality control material and clinical samples.

Results
Fifty-seven sequencing runs of NA12878 were analyzed for 1811 genomic regions targeting 108 genes. Manufactured probe lot changes were associated with significant changes in the average coverage of 537 genomic regions and the lowest coverage of 173 regions (using a critical cut-off of P &lt; 5.52 x 10−6). Genomic regions with the highest sensitivity to lot-to-lot variation by average sequencing depth of coverage were not the same regions with the highest sensitivity by lowest sequencing depth of coverage. Levey-Jennings plots displayed differences in genomic depth of coverage across capture probe reagent lot changes. There was moderate correlation between the changes in depth of sequencing across lot changes for control material and clinical cases (r2 = 0.45).

Conclusions
Genomic control charting can be used routinely by clinical laboratories to monitor assay performance and ensure the quality of testing.
Understanding parameter differences between analyses employing nested data subsets
Authors: Gratton Steven , Challinor Anthony 
Published: October 2020

ABSTRACT
We provide an analytical argument for understanding the likely nature of parameter shifts between those coming from an analysis of a data set and from a subset of that data set, assuming differences are down to noise and any intrinsic variance alone. This gives us a measure against which we can interpret changes seen in parameters and make judgements about the coherency of the data and the suitability of a model in describing those data.
Redshift-space effects in voids and their impact on cosmological tests. Part I: the void size function
Authors: Correa Carlos M , Paz Dante J , Sánchez Ariel G , Ruiz Andrés N , Padilla Nelson D , Angulo Raúl E 
Published: October 2020

ABSTRACT
Voids are promising cosmological probes. Nevertheless, every cosmological test based on voids must necessarily employ methods to identify them in redshift space. Therefore, redshift-space distortions (RSD) and the Alcock–Paczyński effect (AP) have an impact on the void identification process itself generating distortion patterns in observations. Using a spherical void finder, we developed a statistical and theoretical framework to describe physically the connection between the identification in real and redshift space. We found that redshift-space voids above the shot noise level have a unique real-space counterpart spanning the same region of space, they are systematically bigger and their centres are preferentially shifted along the line of sight. The expansion effect is a by-product of RSD induced by tracer dynamics at scales around the void radius, whereas the off-centring effect constitutes a different class of RSD induced at larger scales by the global dynamics of the whole region containing the void. The volume of voids is also altered by the fiducial cosmology assumed to measure distances, this is the AP change of volume. These three systematics have an impact on cosmological statistics. In this work, we focus on the void size function. We developed a theoretical framework to model these effects and tested it with a numerical simulation, recovering the statistical properties of the abundance of voids in real space. This description depends strongly on cosmology. Hence, we lay the foundations for improvements in current models of the abundance of voids in order to obtain unbiased cosmological constraints from redshift surveys.
G0.173−0.42: an X-ray and radio magnetized filament near the galactic centre
Authors: Yusef-Zadeh F , Wardle M , Heinke C , Heywood I , Arendt R , Royster M , Cotton W , Camilo F , Michail J 
Published: October 2020

ABSTRACT
The detection of an X-ray filament associated with the radio filament G0.173–0.42 adds to four other non-thermal radio filaments with X-ray counterparts, amongst the more than 100 elongated radio structures that have been identified as synchrotron-emitting radio filaments in the inner couple of degrees of the Galactic centre. The synchrotron mechanism has also been proposed to explain the emission from X-ray filaments. However, the origin of radio filaments and the acceleration sites of energetic particles to produce synchrotron emission in radio and X-rays remain mysterious. Using MeerKAT, VLA, Chandra, WISE, and Spitzer, we present structural details of G0.173–0.42 which consists of multiple radio filaments, one of which has an X-ray counterpart. A faint oblique radio filament crosses the radio and X-ray filaments. Based on the morphology, brightening of radio and X-ray intensities, and radio spectral index variation, we argue that a physical interaction is taking place between two magnetized filaments. We consider that the reconnection of the magnetic field lines at the interaction site leads to the acceleration of particles to GeV energies. We also argue against the synchrotron mechanism for the X-ray emission due to the short ∼30 yr lifetime of TeV relativistic particles. Instead, we propose that the inverse Compton scattering mechanism is more likely to explain the X-ray emission by upscattering of seed photons emitted from a 106  L⊙ star located at the northern tip of the X-ray filament.
Optimal void finders in weak lensing maps
Authors: Davies Christopher T , Paillas Enrique , Cautun Marius , Li Baojiu 
Published: October 2020

ABSTRACT
Cosmic voids are a key component of the large-scale structure that contain a plethora of cosmological information. Typically, voids are identified from the underlying galaxy distribution, which is a biased tracer of the total matter field. Previous works have shown that 2D voids identified in weak lensing (WL) maps – WL voids – correspond better to true underdense regions along the line of sight. In this work, we study how the properties of WL voids depend on the choice of void finder, by adapting several popular void finders. We present and discuss the differences between identifying voids directly in the convergence maps, and in the distribution of WL peaks. Particular effort has been made to test how these results are affected by galaxy shape noise (GSN), which is a dominant source of noise in WL observations. By studying the signal-to-noise ratios (S/N) for the tangential shear profile of each void finder, we find that voids identified directly in the convergence maps have the highest S/N but are also the ones most affected by GSN. Troughs are least affected by noise, but also have the lowest S/N. The tunnel algorithm, which identifies voids in the distribution of WL peaks, represents a good compromise between finding a large tangential shear S/N and mitigating the effect of GSN.
Magnetorotational core collapse of possible GRB progenitors – II. Formation of protomagnetars and collapsars
Authors: Aloy M Á , Obergaulinger M 
Published: October 2020

ABSTRACT
We assess the variance of the post-collapse evolution remnants of compact, massive, low-metallicity stars, under small changes in the degrees of rotation and magnetic field of selected pre-supernova cores. These stellar models are commonly considered progenitors of long gamma-ray bursts. The fate of the protoneutron star (PNS) formed after the collapse, whose mass may continuously grow due to accretion, critically depends on the poloidal magnetic field strength at bounce. Should the poloidal magnetic field be sufficiently weak, the PNS collapses to a black hole (BH) within a few seconds. Models on this evolutionary track contain promising collapsar engines. Poloidal magnetic fields smooth over large radial scales (e.g. dipolar fields) or slightly augmented with respect to the original pre-supernova core yield long-lasting PNSs. In these models, BH formation is avoided or staved off for a long time, hence, they may produce protomagnetars (PMs). Some of our PM candidates have been run for $\lesssim 10\,$ s after core bounce, but they have not entered the Kelvin–Helmholtz phase yet. Among these models, some display episodic events of spin-down during which we find properties broadly compatible with the theoretical expectations for PMs ($M_\rm {\small PNS}\approx 1.85{-}2.5\, \mathrm{M}_{\odot }$, $\bar{P}_\rm {\small PNS}\approx 1.5 {-} 4\,$ ms, and $b^{\rm surf}_\rm {\small PNS}\lesssim 10^{15}\,$ G) and their very collimated supernova ejecta have nearly reached the stellar surface with (still growing) explosion energies $\gtrsim {2} \times 10^{51}\, \textrm {erg}$.
Identity Metaphysics
Authors: Strawson Galen 
Published: October 2020

AbstractIdentity metaphysics finds identity or unity where other metaphysical theories find difference or diversity. It denies the fundamentality of ontological distinctions that other theories treat as fundamental. It’s opposed to separatism, which mistakes natural conceptual distinctions for ground-floor ontological differences. It proposes that the distinctions between the concepts substance, object, quality, property, process, state, and event are metaphysically superficial; so too the distinctions between the concepts energy, lawsofnature, force, causation, power, and naturalnecessity. So too the distinction between these two sets of concepts. “Thinking takes apart what is really one” (Nietzsche 1885).
Nicotine Dependence in Dual Users of Cigarettes and E-Cigarettes: Common and Distinct Elements
Authors: Rest Eva C , Mermelstein Robin J , Hedeker Donald 
Published: October 2020

Abstract

Introduction
In a sample of dual users of cigarettes and electronic nicotine delivery systems (ENDS; e-cigarettes), we evaluated psychometric properties of ENDS versions of the Nicotine Dependence Syndrome Scale (NDSS), the brief Wisconsin Inventory of Smoking Dependence Motives (WISDM), and the Fagerström Test for Nicotine Dependence (FTND). Using the NDSS, we tested the hypothesis that there would be one common underlying factor of dependence across the cigarette and ENDS scales and other product-specific factors.

Aims and Methods
Adult dual users (N = 404) completed baseline cigarette and ENDS versions of the NDSS, WISDM, and FTND, and biweekly surveys of their smoking and vaping. Analyses included bifactor modeling, which helps to identify both a general and product-specific factor for each item, and exploratory factor analyses of the combined cigarette and ENDS NDSS items and examinations of concurrent and predictive validity.

Results
The bifactor model was not a good fit, suggesting the lack of one common underlying dependence factor. Factor analyses revealed separate, similar factors for both products, with only one factor (priority) showing overlap of cigarette and ENDS items. ENDS scales significantly predicted ENDS use over time, but not cigarette use. Cigarette scales did not predict ENDS use over time.

Conclusions
Although the cigarette and ENDS NDSS versions showed similar factor structure, there was not a primary common underlying factor reflecting drive or tolerance, but rather product-specific factors. The cigarette scales were not valid for predicting ENDS use. These results highlight the importance of separately assessing dependence for cigarettes and ENDS in dual users.

Implications
Although underlying dimensions of nicotine dependence may be similar for ENDS and cigarettes, separate, product-specific measures may be needed to understand differences in product-specific dependency and predict changes in use of each product over time.
Generating Infinite Digraphs by Derangements
Authors: Horsley Daniel , Iradmusa Moharram , Praeger Cheryl E 
Published: October 2020

Abstract
A set $\mathcal{S}$ of derangements (fixed-point-free permutations) of a set V generates a digraph with vertex set V and arcs $(x,x^{\,\sigma})$ for x ∈ V and $\sigma\in\mathcal{S}$. We address the problem of characterizing those infinite (simple loopless) digraphs which are generated by finite sets of derangements. The case of finite digraphs was addressed in an earlier work by the second and third authors. A criterion is given for derangement generation which resembles the criterion given by De Bruijn and Erdős for vertex colourings of graphs in that the property for an infinite digraph is determined by properties of its finite sub-digraphs. The derangement generation property for a digraph is linked with the existence of a finite 1-factor cover for an associated bipartite (undirected) graph.
Endosteal Vasculature Dominates Along the Tibial Cortical Diaphysis: A Quantitative Magnetic Resonance Imaging Analysis
Authors: Levack Ashley E. , Klinger Craig , Gadinsky Naomi E. , Dyke Jonathan P. , Fung Maggie M. , Helfet David L. , Lorich Dean G. 
Published: October 2020

Objective:
Disrupted blood supply has been proposed as an underlying cause for delayed union in tibial shaft fractures (OTA/AO 42). Although tibial blood supply has been qualitatively evaluated, quantitative studies are lacking. The purpose of this project was to quantify the relative contribution of the endosteal supply to the tibial diaphysis.

Methods:
The superficial femoral artery of 8 fresh frozen cadaveric matched pair lower extremities was cannulated. The nutrient artery was ligated at its proximal branch point in experimental limbs. Pregadolinium and postgadolinium enhanced magnetic resonance imaging was performed with high resolution fat-suppressed ultrashort echo time magnetic resonance imaging sequences. Perfusion was assessed in 3 zones (outer, central, and inner cortex) for the proximal, middle, and distal diaphysis, respectively, using custom software to quantify and compare signal intensity between experimental and control limbs.

Results:
On average, the endosteal system supplied 91.4% (±3.9%) of the cortex and was the predominant blood supply for the inner, central, and outer thirds. The dominance of the endosteal contribution was most pronounced in the inner two-third of the cortex, with more than 97% loss of perfusion. Disruption of the nutrient artery also resulted in 76.3% (±11.2%) loss of perfusion of the outer one-third of the cortex.

Conclusion:
This quantitative study revealed a predominance of endosteal blood supply to all areas (inner, middle, and outer thirds) of the tibial diaphyseal cortex. To prevent delayed bone healing, surgeons should take care to preserve the remaining periosteal vascular network in fracture patterns in which the nutrient artery has likely been disrupted.
Systematic Review and Analysis of the Quality of Randomized Controlled Trials Comparing Reamed and Unreamed Intramedullary Nailing of Tibial Fractures
Authors: Clark DesRaj , Vo Loc-Uyen , Piscoya Andres S. , Chan Andrew , Dunn John C. 
Published: October 2020

Objectives:
To evaluate the quality of research and reporting of randomized controlled trials comparing the use of reamed and unreamed intramedullary nails for tibial fractures with validated scoring systems.

Data Source:
PubMed using the search terms “tibia” AND “reamed OR unreamed” AND “intramedullary OR nail.” Filters were applied for the years 1991–2019, full articles, human subjects, and English language.

Study Selection:
Inclusion criteria were (1) prospective and randomized trials, (2) studies reported >80% follow-up, and (3) articles amenable to scoring with the chosen scoring systems. Exclusion criteria were (1) skeletally immature patients or (2) incomplete data sets.

Data Extraction:
Articles were assessed with the Coleman Methodology Score, the Consolidated Standards of Reporting Trials systems, and Cowan's Categorical Rating by 2 independent observers.

Data Synthesis:
Scores for individual articles were averaged for the 2 observers. The total and subcategory scores for all included articles were also averaged with SD from both observers. Categories from the 2 grading systems with deficient reporting were measured as a percentage based on grading from both observers. Data were analyzed using kappa statistic and correlation coefficient to assess agreement and reliability.

Conclusions:
All included articles supported the use of reamed tibial intramedullary nails, but the overall quality of the literature fell in the middle of both the modified Coleman Score and Consolidated Standards of Reporting Trials grading scheme ranges despite being Oxford Level 1.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.