bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Hemorrhagic Fever With Renal Syndrome Using Wavelet Tools in Mainland China, 2004–2019
Authors: Zou Lu-Xi , Sun Ling 
Published: December 2020

Introduction : Hemorrhagic fever with renal syndrome (HFRS) is a life-threatening public health problem in China, accounting for ~90% of HFRS cases reported globally. Accurate analysis and prediction of the HFRS epidemic could help to establish effective preventive measures.Materials and Methods : In this study, the geographical information system (GIS) explored the spatiotemporal features of HFRS, the wavelet power spectrum (WPS) unfolded the cyclical fluctuation of HFRS, and the wavelet neural network (WNN) model predicted the trends of HFRS outbreaks in mainland China.Results : A total of 209,209 HFRS cases were reported in mainland China from 2004 to 2019, with the annual incidence ranged from 0 to 13.05 per 100,0000 persons at the province level. The WPS proved that the periodicity of HFRS could be half a year, 1 year, and roughly 7-year at different time intervals. The WNN structure of 12-6-1 was set up as the fittest forecasting model for the HFRS epidemic.Conclusions : This study provided several potential support tools for the control and risk-management of HFRS in China.
Ten Epidemiological Parameters of COVID-19: Use of Rapid Literature Review to Inform Predictive Models During the Pandemic
Authors: Gallo Luciana Guerra , Oliveira Ana Flávia de Morais , Abrahão Amanda Amaral , Sandoval Leticia Assad Maia , Martins Yure Rodrigues Araújo , Almirón Maria , dos Santos Fabiana Sherine Ganem , Araújo Wildo Navegantes , de Oliveira Maria Regina Fernandes , Peixoto Henry Maia 
Published: December 2020

Objective: To describe the methods used in a rapid review of the literature and to present the main epidemiological parameters that describe the transmission of SARS-Cov-2 and the illness caused by this virus, coronavirus disease 2019 (COVID-19).Methods: This is a methodological protocol that enabled a rapid review of COVID-19 epidemiological parameters.Findings: The protocol consisted of the following steps: definition of scope; eligibility criteria; information sources; search strategies; selection of studies; and data extraction. Four reviewers and three supervisors conducted this review in 40 days. Of the 1,266 studies found, 65 were included, mostly observational and descriptive in content, indicating relative homogeneity as to the quality of the evidence. The variation in the basic reproduction number, between 0.48 and 14.8; and the median of the hospitalization period, between 7.5 and 20.5 days stand out as key findings.Conclusion: We identified and synthesized 10 epidemiological parameters that may support predictive models and other rapid reviews to inform modeling of this and other future public health emergencies.
Path Analisis Technology Acceptance Model pada Penerapan Blended Learning
Authors: Saptomo Wawan Laksito Yuly , Rimawati Elistya 
Published: December 2020

Model pembelajaran Blended Learning adalah sistem yang mengkolaborasikan pembelajaran tatap muka kelas dengan pembelajaran online memanfaatkan E-Learning. Penelitian ini bertujuan untuk mengukur tingkat penerimaan dan perilaku peserta didik terhadap teknologi dari model pembelajaran Blended Learning. Variabel yang dikembangkan merujuk pada Technology Acceptance Model (TAM), yaitu model penerimaan pengguna terhadap sistem informasi. Model TAM dikembangkan dari teori psikologis yang menjelaskan bahwa perilaku pengguna sistem berlandaskan pada kepercayaan, sikap, keinginan, dan hubungan perilaku pengguna. Data yang diperoleh dianalisis hubungan struktur variabel dengan Structural Equation Modeling (SEM) menggunakan metode Partial Least Square (PLS). Berdasarkan hasil Analisa PLS dan Boostraping diperoleh nilai Pengaruh Langsung, Pengaruh Tidak Langsung, dan Pengaruh tidak langsung sesuai jalur spesifikasi melalui variabel intervening (Spesific Indirect Efect).
Como el «capitán de la libertad» llegó a matar al «defensor de los indios» – el contexto sociopolítico del asesinato del tercer obispo de Nicaragua, fray Antonio de Valdivieso
Authors: Demkowicz Karol , Andrzejewska Agata 
Published: December 2020

En 1550 el tercer obispo de la diócesis de Nicaragua murió asesinado por los hijos del ex-gobernador, Rodrigo de Contreras. La causa directa de este delito fue la enemistad personal entre los asaltantes y la víctima, sin embargo el incidente formaba parte de un fenómeno amplio, compuesto por la explotación de indios, los confl ictos internos en la sociedad hispana de la colonia y la gran política imperial en el Nuevo Mundo recién conquistado.
MEKANISME PERTAHANAN DIRI DALAM NOVEL <em>KAKI LANGIT TALUMAE</em> KARYA WISHNU MAHENDRA: KAJIAN PSIKOLOGI SASTRA <em>
Authors: Febrianto Diki , Anggraini Purwati 
Published: December 2020

ABSTRAKTujuan dari penelitian ini untuk mendeskripsikan mekanisme pertahanan diri tokoh dalam novel Kaki Langit Talumae karya Wishnu Mahendra ditinjau dari psikoanalisis. Metode dalam penelitian ini menggunakan metode deskriptif analisis, yang memaparkan data melalui kaliamat, frasa, klausa. Data dalam metode deskriptif berupa kata maupun kumpulan kata, bukan angka. Sumber data penelitian ini adalah novel Kaki Langt Talumae karya Wishnu Mahendra. Teknik pengumpulan data diawali dengan observasi melalui membaca dan mencatat data yang penting terkait penelitian. Teknik analisis data pada penelitian ini menggunakan psikologi sastra Sigmund Freud (mekanisme pertahanan diri). Penelitian ini menggunakan pendekatan deskriptif kualitatif. Hasil dari penelitian ini yaitu, pertama, mengungkap mekanisme pertahanan diri tokoh pada novel Kaki Langit Talumae karya Wishnu Mahendra. Adapun hasil dari penelitian ini bentuk sistem pertahanan diri yaitu, represi, sublimasi, proyeksi, pengalihan, rasionalisasi, regresi, dan agresi. Â Â Â Â Â Kata Kunci: mekanisme pertahanan diri, psikologi sastraÂ ABSTRACTThe purpose of this research is to describe the self defense mechanism of the characters in the novel Langit Langit Talumae by Wishnu Mahendra in terms of psychoanalysis. The method in this study uses descriptive analysis method, which presents data through kaliamat, phrases, clauses. Data in descriptive methods are words and collections of words, not numbers. The data source of this research is the novel of Kaki Langt Talumae by Wishnu Mahendra. Data collection techniques begin with observation through reading and recording important data related to research. Data analysis techniques in this study used the literature psychology of Sigmund Freud (self defense mechanism). This research use desciptive qualitative approach. The results of this study are, first, to reveal the character's self defense mechanism in the novel Langit Langit Talumae by Wishnu Mahendra. The results of this research form self defense systems namely, repression, sublimation, projection, diversion, rationalization, regression, and aggression.Keywords: self defense mechanism, psychology literature
De Juan Ambrosio Huerta a Mariano Holguín: episcopado, ultramontanismo y modernidad en Arequipa (1880-1935)
Authors: Iberico Ruiz Rolando 
Published: December 2020

En el Perú, ante el avance de sectores liberales en Lima, Arequipa se constituyó como una ciudad baluarte del catolicismo. En este proceso, el episcopado jugó un papel clave como dinamizador de espacios de formación ultramontana para el clero y el laicado, de promoción de sociedades laicales apologéticas y ociales, de consolidación de prácticas piadosas y de construcción de una legitimidad pública para la Iglesia en la ciudad. En este sentido, este artículo estudia el proceso de afianzamiento del ultramontanismo y del catolicismo social de los episcopados de José Ambrosio Huerta, Manuel Ballón y Mariano Holguín. De esta manera, la Iglesia fortaleció su presencia en el espacio público regional y pudo articular un discurso sobre la modernidad desde la perspectiva católica, a favor de la presencia pública de la Iglesia como estructuradora de la vida política, social y moral en la ciudad.
El Oncenio de Leguía y las relaciones bilaterales Perú-Chile: entre el «antichilenismo» popular y la búsqueda de concordia (1919-1930)
Authors: Valle Vera María Lucía 
Published: December 2020

La solución del conflicto limítrofe con Chile fue el asunto prioritario en materia de Relaciones Exteriores que Augusto B. Leguía asumió en su segundo periodo de gobierno conocido como el Oncenio (1919-1930). El artículo aborda el antichilenismo popular presente entre la población de Lima en aquel contexto e identifica sus características, manifestaciones y la forma en la que habría afectado a la población chilena residente en la ciudad. Además, se analiza la dinámica y relación entre aquel y el discurso oficial del gobierno de Leguía, quien manipuló el discurso antichileno conforme a sus intereses en las negociaciones con el gobierno chileno.
Hidden Worlds
Authors: Rosenbaum J 
Published: December 2020

This art project examines non-binary and transgender identity through training machines to generate art based on Greek and Roman statuary. The statuary is binary in nature and appeals to the concept of pinnacles of masculinity and femininity but what of those of us who fall between, what of transgender bodies, gender non-conforming and non-binary bodies and intersex bodies?
Image recognition algorithms have a difficult time classifying people who fall outside the binary, those who don’t pass as cisgender and those who present in neutral or subversive ways. As image recognition becomes more prevalent, we need to have a past and a future for everyone who doesn’t fit neatly into one of the only two boxes on offer. We need to open up the categories, allow people to self-identify or to scrap the concept of gendering people mechanically all together.
As a spatial installation, Hidden Worlds also explores the embodiment of interactive augmented reality bodies in the space between physical and digital worlds. I have worked with a classifier and some deliberately abstract figure works, generated by machine, to explore where gender is assigned in the process and what it looks like when you aren’t neatly classified, and the disconnect that is felt when misgendered. The generated captions have flipped around gender and as the figure resolves and each section is submitted to the narrative writer you see a different set of pronouns, a disconnection between what you see and what you hear. I will explore the assumptions we make about classical art; the way it can inform how we represent gender minorities going forward and how art can illustrate the gaps that exist in the training of these important machine learning systems.
Performance and New Materialism: Towards an expanded notion of a non-human agency
Authors: Choat Alyssa 
Published: December 2020

This research paper expands on new materialist notions of material agency within the context of practice-based creative research. New materialist thinking provides a recognition of the agency of non-human actors, and enables a focus on the dynamics of human and non-human relationships. A key concept of new materialist theory is a critical perspective on the binary of human and non-human, arguing that all matter resides within a form of incessant flow, in states of constant transformation. These renewed approaches to understanding matter has drawn from developments in science and physics exploring the nature of forces and networks that constitutes matter. In a world that is continuing to become more technologically reliant and scientifically developed, this research paper explores a non-human agency emerging within human and non-human interactions, where human and non-human agents (spaces, materials, forces, etc) have efficacy in the co-construction of practices, events and figurations, drawn from looking at the nature of these relationships that unfolded in the performance works. In this paper I will be discussing two performances that were undertaken Material Interactions[i] and BodyBody Experiments [ii]. Considering these works within a theoretical framework of analysis which draws from New Materialist thinking on non-human agency

[i] Choat, Alyssa. Material Interactions, 2017.
[ii] Choat, Alyssa. Bodybody Experiments, 2017.
Long- and Short-term Variability of Galactic Cosmic-Ray Radial Intensity Gradients between 1 and 9.5 au: Observations by Cassini, BESS, BESS-Polar, PAMELA, and AMS-02
Authors: Roussos Elias , Dialynas Konstantinos , Krupp Norbert , Kollmann Peter , Paranicas Christopher , Roelof Edmond C. , Yuan Chongjing , Mitchell Donald G. , Krimigis Stamatios M. 
Published: December 2020

Abstract
Spatial gradients of galactic cosmic-ray (GCR) fluxes are important for studying charged particle transport in the heliosphere. Little is known so far about how these gradients evolve with time. Here we present how the radial gradient (G

r
) evolves between 2006 January and 2017 September using Cassini measurements of >300 MeV protons, which we combine with proton spectra obtained by advanced observatories at Earth (BESS, BESS-Polar, PAMELA, and AMS-02). All gradient calculations were performed for a nearly constant heliocentric distance of Cassini from Earth’s orbit and near the ecliptic, thus revealing only how G

r
changes with time. The variability patterns of G

r
are well established as they rely on a single data set for ∼9.5 au and accurately cross-calibrated GCR spectra for Earth at 1 au. We show that over solar-cycle timescales, G

r
is regulated by both the polarity of the solar magnetic field and the solar-cycle phase. During the negative-polarity phase (A < 0, 2006–2014), gradients are stronger and more stable with an average of G

r
= 3.5 ± 0.3%/au and with evidence of a minimum around the 2009 solar minimum. The gradient peaks at ∼4%/au around the solar maximum and subsequently experiences a gradual drop to ∼2%/au in the A > 0 phase (2014–2017). Regular G

r
enhancements over yearly or biennial timescales are also observed, in phase with quasi-biennial oscillations in GCR intensity. While all aforementioned results are based on Cassini measurements that are integral in energy, they are most representative for GCR protons in the low gigaelectronvolt range.
Are Farming and Animal Exposure Risk Factors for the Development of Granulomatosis With Polyangiitis? Environmental Risk Factors Revisited: A Case-control Study
Authors: Lindberg Hanna , Colliander Caroline , Nise Lena , Dahlqvist Johanna , Knight Ann 
Published: December 2020

Objective.To investigate the possible association between animal exposure and risk for granulomatosis with polyangiitis (GPA).Methods.Patients with GPA at the Department of Rheumatology, Uppsala University Hospital, between January 1, 2011, and December 31, 2018, were consecutively included. All patients filled in a questionnaire on possible environmental exposures: occupation, hobbies, and animal contact. As controls we included 128 patients with rheumatoid arthritis (RA) and 248 population controls collected from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study, matched for age, sex, and geographical area of residence. The controls filled out a questionnaire on current and past contact with farming and animals, at the time of the RA patient’s diagnosis.Results.A total of 62 patients with GPA, 128 patients with RA, and 248 population controls were included in the study. GPA was significantly associated with horse exposure, with a 2- to 3-fold increased risk compared with RA (OR 3.08, 95% CI 1.34–7.08) and population controls (OR 2.61, 95% CI 1.29–5.29). Borderline increased risks were found for any animal contact, but no association was found when analyzing contact with cats/dogs only. A significant association was found between GPA and farming compared to the population controls (OR 7.60, 95% CI 3.21–17.93).Conclusion.This study has identified for the first time, to our knowledge, a significant association between exposure to specific animals, namely horses, and the development of GPA. The results also support previous studies reporting an association between farming and GPA, underscoring the possibility of exogenous factors as initiators in the development of GPA.
Predicting Macrophage Activation Syndrome in Childhood-onset Systemic Lupus Erythematosus Patients at Diagnosis
Authors: Gerstein Maya , Borgia R. Ezequiel , Dominguez Daniela , Feldman Brian M. , Liao Fangming , Levy Deborah M. , Ng Lawrence , Abdelhaleem Mohamed , Silverman Earl D. , Hiraki Linda T. 
Published: December 2020

ObjectiveMacrophage activation syndrome (MAS), a life-threatening inflammatory complication, is increasingly recognized in childhood-onset systemic lupus erythematosus (cSLE). It can be a challenge to differentiate active cSLE from MAS. We generated decision rules for discriminating MAS from active cSLE in newly diagnosed patients.MethodsWe conducted a retrospective cohort study of consecutive, newly diagnosed, active cSLE patients with fever, requiring hospital admission to The Hospital for Sick Children from January 2003 to December 2007 (cohort 1) and January 2008 to December 2013 (cohort 2). All patients met ≥ 4 American College of Rheumatology or Systemic Lupus International Collaborating Clinics criteria, and were steroid-naïve and infection-free. MAS was diagnosed based on expert opinion. Recursive partitioning was applied to each cohort to derive a decision rule based on clinical and laboratory features, distinguishing MAS from non-MAS cSLE. Each decision rule was applied to the alternate, independent cohort. Sensitivity and specificity of these decision rules were compared to existing criteria.ResultsCohort 1 (n = 34) and cohort 2 (n = 41) each had 10 patients with MAS. Recursive partitioning in cohort 1 identified ferritin ≥ 699 μg/L as the sole best discriminator between MAS and non-MAS patients (R2 = 0.48), and in cohort 2, ferritin ≥ 1107 μg/L was the best discriminator for MAS, followed by lymphocytes < 0.72 × 103/mm3 (R2 = 0.52). Cross-validation of our decision rules maintained 90–100% sensitivity and 65–85% specificity.ConclusionOur decision rule demonstrated improved performance compared to preliminary guidelines for MAS in cSLE from the Lupus Working Group of the Paediatric Rheumatology European Society and familial hemophagocytic lymphohistiocytosis diagnostic criteria. Validation in independent cohorts is required.
Evaluation of the Effect of Diabetes on Rheumatoid Arthritis–related Outcomes in an Electronic Health Record–based Rheumatology Registry
Authors: Yun Huifeng , Xie Fenglong , Chen Lang , Yang Shuo , Ferri Leticia , Alemao Evo , Curtis Jeffrey R. 
Published: December 2020

Objective.Patients with rheumatoid arthritis (RA) who also have diabetes mellitus (DM) might have worse clinical outcomes and adverse events compared to patients with RA who do not have DM. We evaluated the effects of DM on Health Assessment Questionnaire (HAQ) changes and outpatient infection rates in patients with RA.Methods.Using the American College of Rheumatology’s Rheumatology Informatics System for Effectiveness (RISE) electronic health record–based registry, we identified patients with RA who had ≥ 1 rheumatologist visit with a HAQ measured in 2016 (index visit), ≥ 1 previous visit, and a subsequent outcome visit with the same HAQ measured at 12 months (± 3 months). We identified DM by diagnosis codes, medications, or laboratory values. Outpatient infection was defined by diagnosis codes or antiinfective medications. We calculated mean HAQ change and incidence rate (IR) of outpatient infections among patients with and without DM. Generalized linear models and Cox regression were used to calculate the adjusted mean HAQ change and HRs.Results.We identified 3853 RA patients with DM and 18,487 without DM. The mean HAQ change between index and outcome visit among patients with DM was 0.03 and without DM was 0.002 (P< 0.01). We identified 761 outpatient infections for patients with DM with an IR of 22.6 (95% CI 21.0–24.2) per 100 person-years and 3239 among patients without DM with an IR of 19.8 (95% CI 19.1–20.5). The adjusted HR of outpatient infections among patients with DM was 0.99 (95% CI 0.91–1.07), compared to patients without DM.Conclusion.Patients with RA with concomitant DM had greater worsening, or less improvement, in their functional status, suggesting additional interventions may be needed for RA patients with DM to optimize treatment and management of other comorbidities.
Metaanalysis Reveals Genetic Correlates of Osteoporosis Pathogenesis
Authors: Hasan Laith K. , Aljabban Jihad , Rohr Michael , Mukhtar Mohamed , Adapa Nikhil , Salim Rahaf , Aljabban Nabeal , Syed Saad , Syed Sharjeel , Panahiazar Maryam , Hadley Dexter , Jarjour Wael 
Published: December 2020

Objective.Osteoporosis is a growing healthcare burden. By identifying osteoporosis-promoting genetic variations, we can spotlight targets for new pharmacologic therapies that will improve patient outcomes. In this metaanalysis, we analyzed mesenchymal stem cell (MSC) biomarkers in patients with osteoporosis.Methods.We employed our Search Tag Analyze Resource for the Gene Expression Omnibus (STARGEO) platform to conduct a metaanalysis to define osteoporosis pathogenesis. We compared 15 osteoporotic and 14 healthy control MSC samples. We then analyzed the genetic signature in Ingenuity Pathway Analysis.Results.The top canonical pathways identified that were statistically significant included the serine peptidase inhibitor kazal type 1 pancreatic cancer pathway, calcium signaling, pancreatic adenocarcinoma signaling, axonal guidance signaling, and glutamate receptor signaling. Upstream regulators involved in this disease process includedESR1, dexamethasone,CTNNβ1, CREB1, andERBB2.Conclusion.Although there has been extensive research looking at the genetic basis for inflammatory arthritis, very little literature currently exists that has identified genetic pathways contributing to osteoporosis. Our study has identified several important genes involved in osteoporosis pathogenesis includingESR1, CTNNβ1, CREB1, andERBB2. ESR1has been shown to have numerous polymorphisms, which may play a prominent role in osteoporosis. The Wnt pathway, which includes theCTNNβ1gene identified in our study, plays a prominent role in bone mass regulation. Wnt pathway polymorphisms can increase susceptibility to osteoporosis. Our analysis also suggests a potential mechanism forERBB2in osteoporosis through Semaphorin 4D (SEMA4D). Our metaanalysis identifies several genes and pathways that can be targeted to develop new anabolic drugs for osteoporosis treatment.