bluuebunny/crossref_metadata_2025_split huggingface dataset:
Productivity and Profitability of Mechanized Deep Nitrogen Fertilization in Mechanical Pot-Seedling Transplanting Rice in South China
Authors: Li Lin , Zhang Zheng , Tian Hua , Ashraf Umair , Mo Zhaowen , Duan Meiyang , Wang Zaiman , Wu Tiaoyan , Tang Xiangru , Pan Shenggang 
Published: October 2020

Abstract
Background: The deep nitrogen (N) fertilization coupled with mechanical pot-seedling transplanting rice (DNF-MPT) is an effective alternative to traditional transplanted rice with broadcasting fertilizer, however, little is known about its effects on grain yield, nutrient accumulation, and economic profitability. In present study, a two-year field experiment was conducted in early seasons (March-July) of 2019 and 2020. All seedlings were transplanted by DNF-MPT, whereas four treatments were designed as: MD: mechanized deep placement of all fertilizers as base fertilizer; MDB: mechanized deep placement of 70% fertilizers as basal fertilizer, 30% broadcasting fertilizers at panicle initiation stage; MB: manual broadcasting of 40%, 30% and 30% fertilizers at the transplanting, tillering and panicle initiation stages, respectively; and CK: no fertilizer was applied during entire growth stages. Results: The results indicated that MD treatment substantially improved the grain yield by 33.48-36.35%, total nitrogen accumulation (TNA) by 26.38-44.15%, total phosphorus accumulation (TPA) by 28.72-30.23%, and total potassium accumulation (TKA) by 25.61-37.33%, respectively, compared with MB treatment. Deep placement of N fertilization treatments i.e., MD and MDB remarkably promoted root morphological indexes and total root dry weight. Furthermore, nitrate reductase (NR), glutamine synthetase (GS) activities and total chlorophyll content (total Chl) of leaves were also enhanced under deep placement of N fertilizer. Overall, the MD treatment had the highest benefit cost ratio (BCR) owing to high gross returns and low input costs. Conclusions: Deep placement of N fertilizer coupled with mechanical pot-seedling transplanting rice could be better alternative to conventional rice production system with more economic benefits.
Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention in Coronary Artery Disease Patients with Advanced Chronic Kidney Disease: A Chinese Single-Center Study
Authors: Li Yang , Rui Hongliang , Huang Zhuhui , Xu Xiaoyu , Liu Taoshuai , Zheng Jubing , Hou Xuejian , Xu Shijun , Dong Ran 
Published: October 2020

Abstract
Objectives Aims to compare the contemporary and long-term outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients with advanced chronic kidney disease (CKD). Design Observational cohort study, single-center.Setting The largest cardiac surgery center in China.Participants 823 CAD patients with advanced CKD (eGFR<30 ml/min/1.73m2) were collected, including 247 patients who underwent CABG and 576 patients received PCI from January 2010 to February 2019. Main outcome measures The primary end point was all-cause death. The secondary end points included major adverse cardiac and cerebrovascular events (MACCEs), myocardial infarction (MI), stroke and revascularization.Results Multivariable Cox regression models were used for risk-adjustment and propensity score matching (PSM) was also performed. After PSM, the 30-day mortality rate in the CABG group was higher than that in the PCI group but without statistically significant (6.6%vs2.4%, p=0.0640). During the first year, patients referred for CABG had a hazard ratio (HR) of 1.42 [95% confidence interval (CI), 0.41–3.01] for mortality compared with PCI. At the end of the 5-year follow-up, CABG group had a HR of 0.58 (95%CI, 0.38-0.86) for repeat revascularization, a HR of 0.77 (95%CI, 0.52-1.14) for survival rate and a HR of 0.88(95%CI, 0.56-1.18) for MACCE as compared to PCI. Conclusions Our study suggests that among advanced CKD patients，CABG showed obviously lower risk for repeat revascularization and slightly better prognosis regarding to mortality and other adverse events compared with PCI during the long-term follow-up. At a mean pooled follow-up of one year, both mortality and MACCEs were comparable in both cohorts.
Surgery for&nbsp;Primary Giant Acinic Cell Carcinoma of Right Lung with Severe Mediastinal Deviation: A Case Report
Authors: Chen Xueyu , Zhang Nengchong , Luo Fangxiu , Zhu Lianggang 
Published: October 2020

Abstract
Background: Primary lung acinic cell carcinoma is very rare.Here we report a young female patient who suffered the largest primary lung acinic cell carcinoma and severe mediastinal deviation at the same time which has never been reported before.Case presentation: A 27-years-old married female patient presented with recurrent coughing and hemoptysis for more than ten years came to our hospital.A chest computed tomography was performed in our hospital and showed a giant space-occupying lesion in the hilum of right lung.After a thorough and detailed preoperative examination,the patient then was performed a radical right pneumonectomy and mediastinal lymph node dissection.The specimens and pathology showed that the size of the tumor was about 8.6×4.5×4.4cm.The morphology of the tumor cell under microscope demonstrate a primary acinic cell carcinoma of right lung.The immunohistochemistry of the tumor showed AE1/AE3(+), Ki-67(2% +), CK7(+), Calponin(+/-), Vimentin(+), CK19(+), a-ACT(+), PAS(partial+). The patient was discharged two weeks after the operation.So far,the patient has been followed-up for one year, all the clinical test indexes are normal and no evidence of tumor recurrence or metastasis was observed. Conclusions: The primary acinic cell carcinoma of lung in this case is the biggest one ever been reported.The patient also had a very rare condition of severe mediastinal deviation.After surgical treatment, the patient recovered uneventfully and had stable disease without recurrence after one year of follow-up.This case indicates that acinic cell carcinoma of lung is of low malignancy, the prognosis and therapy effect of surgical treatment are satisfied.
Can Enhancement Pattern and Enhancement Level on Biphasic Enhanced CT&nbsp;Distinguish Homogeneous Pheochromocytomas From Adenomas Without Lipid
Authors: An Yongyu , Tian Fengjuan , Lin Bin , Shao Meihua , Zhu Fangmei , Ji Hongli , He Linyang , Hu Qiuxiang , Wang Jian 
Published: October 2020

Abstract
Objective The purpose of our study was to evaluate whether enhancement pattern and enhancement level on biphasic enhanced CT can distinguish homogeneous pheochromocytomas from adenomas without lipid and explore the value of percentage of peak enhancement (PPE) in differentiating the two entities.Methods We retrospectively analysed pathologically proven 17 pheochromocytomas and 34 adenomas. Both tumors were homogeneous without necro-cystic changes and hemorrhage. The inclusion criteria for adenomas without lipid in our study was that the mean attenuation values were greater than 10 HU and the minimum values were greater than 0 HU on unenhanced CT. Biphasic CT scan protocol consisted of unenhanced phase, arterial phase (25-35 seconds) and venous phase (60-80 seconds). The enhancement pattern, attenuation values on unenhanced and enhanced phases and PPE were compared between the two groups.Results Enhancement pattern was similar between the two groups (p>0.99), persistent enhancement pattern on venous phase was the most common in both tumors. The precontrast CT values of pheochromocytomas were significantly higher than that of adenomas without lipid (41 HU vs 37 HU, p=0.006). The enhancement level on arterial and venous phase of pheochromocytomas was greater than that of adenomas without lipid, but no significant differences were found (100 HU vs 85 HU, p=0.223; 103 HU vs 96 HU, p=0.905, respectively). The distribution of PPE of two entities was different. A range of 100%-240% of PPE can discriminate adenomas without lipid from pheochromocytomas, with sensitivity of 88.2%, specificity of 47.1%. Conclusion The enhancement pattern and enhancement level on biphasic enhanced CT could not distinguish homogeneous pheochromocytomas from adenomas without lipid. Further studies are needed to prove the potential value of PPE due to its low specificity.
The Potential of Adipokines in Identifying Multiple Trauma Patients at Risk of Developing Multiple Organ Dysfunction Syndrome
Authors: Haupt Julian , Krysiak Niels , Unger Marina , Bogner-Flatz Viktoria , Biberthaler Peter , Hanschen Marc , Griensven Martijn van , Haug Alexander T. 
Published: October 2020

Abstract
BackgroundMultiple organ dysfunction syndrome (MODS) and the consecutive multiple organ failure (MOF) are severe and dreaded complications with a high mortality in multiple trauma patients. The aim of this study was to investigate the potential of the adipokines leptin, resistin, interleukin-17A and interleukin-33 as possible biomarkers in the early posttraumatic inflammatory response and for identifying severely traumatized patients at risk of developing MODS.MethodsIn total, 14 multiple trauma patients with an injury severity score (ISS) ³ 16 as well as a control group of 14 non-multiple trauma patients were included in this study and blood samples were taken at the time points 0, 6, 24, 48 and 72h after admission. For the trauma patients, the SIRS and Denver MOF score were determined daily. The quantitative measurement of the plasma concentrations of the adipokines was performed using ELISA. ResultsIn the statistical analysis, the multiple trauma patients showed statistically significant higher plasma concentrations of leptin, resistin, IL-17A and IL-33 compared to the control group. In addition, there was a statistically significant positive correlation between the concentrations of resistin, IL-17A and IL-33 and the corresponding SIRS scores and between the concentrations of resistin, IL-17A and IL-33 and the corresponding Denver MOF scores. Finally, ROC curve analysis revealed that the adipokines leptin and IL-17A are suitable diagnostic markers for the discrimination between multiple trauma patients with and without MOF. ConclusionsThe results of this study may contribute to identify severely injured patients with a developing SIRS and MOF earlier, in order to adjust therapy strategies.
Maximum Standardized Uptake Value in Lymph Nodes Measured by 18F-FDG PET/CT Predicts the Outcome of Patients with Oesophagus Squamous Cell Carcinoma
Authors: Ren Wenjia , Chen Weiwei , Chen Yun , Liu Qi , Ai Dashan , Deng Jiaying , Zhao Kuaile 
Published: October 2020

Abstract
Background: To investigate the prognostic value of 18F–fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in esophagus squamous cell carcinoma (ESCC), PET/CT imaging characteristics were explored in the present study.Methods: Baseline PET/CT and clinical characteristics were collected in 125 patients with ESCC treated with radical radiotherapy from 2007–2016. The maximum standardized uptake value (SUVmax) of the primary gross tumour (SUVmax-T) and metastatic lymph node (SUVmax-N) were separately measured using X-tile. Overall survival (OS) and progression free survival (PFS) were estimated according to the Kaplan–Meier method. A multivariate Cox model was used to establish the independent prognostic factors.Results: The gross tumours presented higher 18F-FDG uptake than normal tissues with a median SUVmax-T of 12.5. The OS and PFS did not show significant differences between patients with SUVmax-T ≥ 12.5 and those with SUVmax-T <12.5 (P>0.05). However, patients with SUVmax-N ≥ 11 had a significantly worse OS and PFS than those with SUVmax-N <11 (P<0.05). A weak correlation was observed in SUVmax-T and SUVmax-N. The OS and PFS of patients with PET-negative LNs was significantly better than those with PET-positive LNs. However, the OS and PFS of patients with one or two PET-positive LNs were not significantly better than those with more than two PET-positive LNs. In the univariate analysis, cT stage, positive or negative lymph nodes on the PET-CT image and the SUVmax-N were established as significant prognostic factors for both OS and PFS. In multivariate analysis, SUVmax-N was proved to be an independent predictor for OS and PFS.Conclusions: SUVmax-N, but not SUVmax-T, is an independent prognostic indicator for patients with ESCC.
A Simple and Cost-effective Technique for Deep Inspiration Breath-hold Radiotherapy in Left-sided Breast Cancer Patients: A Retrospective Study
Authors: Koide Yutaro , Kitagawa Tomoki , Aoyama Takahiro , Shimizu Hidetoshi , Wakabayashi Kohei , Miyauchi Risei , Tanaka Hiroshi , Tachibana Hiroyuki , Kodaira Takeshi 
Published: October 2020

Abstract
Background: Deep inspiration breath-hold (DIBH) radiotherapy is effective but requires specific devices for tracking the respiratory cycle or surface motion. There are some reports of DIBH without such devices. However, to the best of our knowledge, no study has evaluated all three components which are: setup accuracy, dose assessment, and treatment time. We evaluated the accuracy, effect of dose reduction on organs at risk (OARs), and the treatment time of our DIBH technique, which avoids the use of such devices.Methods: We analyzed 64 left-sided early breast cancer patients. Three-dimensional conformal radiotherapy treatment plans of 42.56 Gy in 16 fractions were created in free-breathing (FB) and DIBH settings. Thirty patients were evaluated for inter- and intra-fractional displacement. The treatment room entry-to-exit times were measured and retrospectively compared with those of 44 right breast cancer patients who received FB radiotherapy (Right-FB) in the same period. The volumes and dose metrics of the clinical target volume (CTV) and contoured OARs (HEART, left anterior descending artery [LAD], and LUNG) were compared between FB and DIBH.Results: The average inter-fractional, intra-fractional, and overall setup displacement were 2.32 ± 1.30, 0.55 ± 0.43, and 2.46 ± 1.24 mm, respectively. Compared to Right-FB, the medians of entry-to-exit times slightly increased in DIBH (9 vs 7 minutes, P = 3.95e-23). The LUNG volume in DIBH was 1.58 times larger than that in FB, but other volumes were not statistically different. Compared to FB, the median HEART, LAD, and mean LUNG doses decreased significantly in DIBH: 1.67 vs 0.71 (P = 9.72e-15), 13.0 vs 2.3 (P = 6.65e-15), and 2.42 vs 2.03 (P = 6.80e-8) Gy, respectively. CTV doses were not statistically different.Conclusions: With only minor setup errors, this simple and cost-effective DIBH technique is a feasible method. It can be easily tested for new facilities and is expected to accelerate the further clinical implementation.Trial registration:
An Application Deployment Approach for City IoT&nbsp;Applications in Resource-constrained Edge Computing Environments
Authors: Liu Jialei , Huang Quanzhen 
Published: October 2020

Abstract
With the development and utilization of more and more city Internet of Things (IoT) applications with high resource requirements, how to reduce the consumption of energy, processor resources and bandwidth resources in resource-constrained edge clouds while ensuring the execution delay of these applications is an urgent problem to be solved. Therefore, an optimal energy-bandwidth tradeoff deployment approach for city IoT application is proposed for resource-constrained edge clouds. In this approach, the city IoT applications are first divided into multiple collaborative tasks and offload to edge clouds. Secondly, a joint optimization model including energy consumption, resource wastage, resource load imbalance and bandwidth resource consumption is established for the task offloading scheme. Thirdly, the city IoT application deployment problem is optimized under the constraints of resource and execution delay. Finally, a comprehensive simulation test is conducted to analyze the deployment approaches from the aspects of performance and effectiveness. The experimental results show that our deployment approach is superior to other related approaches.
Contribution of Nontraditional Lipid Profiles to Hyperuricemia in a Hypertensive Population: Findings from the China Hypertension Registry Study
Authors: Yu Yu , Fang Wangsheng , Wang Dandan , Tao Yu , Li Minghui , Huang Xiao , Zhou Wei , Wang Tao , Zhu Lingjuan , Bao Huihui , Cheng Xiaoshu 
Published: October 2020

Abstract
Background: Current studies support nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL -C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C)] as reliable indicators of cardiovascular disease, stroke and diabetes. However, whether nontraditional lipid profiles can be used as reliable markers for hyperuricemia (HUA) remains unclear due to limited research. The present study investigated the relationship of nontraditional lipid profiles with HUA in hypertensive patients.Methods: We analyzed data from 13,721 Chinese hypertensive population untreated with lipid-lowering drugs. The relationship between non-traditional lipid profiles and HUA was examined by multivariate logistic regression analysis and smooth curve fitting (penalized spline method).Results: The results showed that there were positive associations of TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C with HUA, respectively (all P <0.001). Furthermore, nontraditional lipid profiles were converted from continuous variables to tertiles. Compared with lowest tertile, the multivariate adjusted ORs (95% CI) of TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio and non-HDL-C in highest tertile were 1.79 (1.62, 1.99), 2.09 (1.88, 2.32), 1.67 (1.51, 1.86), 1.93 (1.74, 2.13), respectively (all P <0.001).Conclusions: In Chinese hypertensive population, there were positive associations between nontraditional lipid profiles (TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C) and HUA. Our findings further expand the scope of application of nontraditional lipid profiles. These novel and important results suggest that nontraditional lipid profiles can be used as potential and valuable indicators of HUA, and provide a new strategy for the prevention and treatment of HUA.
N-terminal Domain Regulates Steroid Activation of Elephant Shark Glucocorticoid and Mineralocorticoid Receptors
Authors: Katsu Yoshinao , Shari Islam MD , Lin Xiaozhi , Takagi Wataru , Urushitani Hiroshi , Kohno Satomi , Hyodo Susumu , Baker Michael E. 
Published: October 2020

Abstract
Orthologs of human glucocorticoid receptor (GR) and human mineralocorticoid receptor (MR) first appear in cartilaginous fishes. Subsequently, the MR and GR diverged to respond to different steroids: the MR to aldosterone and the GR to cortisol and corticosterone. We report that cortisol, corticosterone and aldosterone activate full-length elephant shark GR, and progesterone, which activates elephant shark MR, does not activate elephant shark GR. However, progesterone inhibits steroid binding to elephant shark GR, but not to human GR. Together, this indicates partial functional divergence of elephant shark GR from the MR. Deletion of the N-terminal domain (NTD) from elephant shark GR (truncated GR) reduced the response to corticosteroids, while truncated and full-length elephant shark MR had similar responses to corticosteroids. Swapping of NTDs of elephant shark GR and MR yielded an elephant shark MR chimera with full-length GR-like increased activation by corticosteroids and progesterone compared to full-length elephant shark MR. Elephant shark MR NTD fused to GR DBD+LBD had similar activation as full-length MR, indicating that the MR NTD lacked GR-like NTD activity. We propose that NTD activation of human GR evolved early in GR divergence from the MR.
Effects of Covid-19 confinement on the mental health of children and adolescents in Spain
Authors: Ordóñez-Camblor Nuria , Pizarro-Ruiz Juan Pablo 
Published: October 2020

Abstract
In Spain, in order to control COVID-19 transmission, one of the strictest confinement measures in the world for children and teenagers has been implemented. From 14 March to 26 April 2020 underage Spaniards were not allowed to leave their homes, except for reasons of force majeure. This could have consequences on their mental health in both the short and the long term. Thus, the aim of the present study was to explore the consequences of confinement on the mental health of Spanish children and teenagers, at the time when minors had been locked down in their homes between 8 and 10 days. The sample was composed of 590 confined Spanish children and teenagers between 8 and 18 years old. The scales of Depression, Self-esteem, Anxiety, Problems with Emotional Regulation, Rage Control Problems, Integration and Social Competence, Somatic Complaints, Rebellious Behaviour, as well as Awareness of the Problems of the Assessment System for Children and Adolescents (SENA) were used.The results revealed that, during confinement, children and adolescents showed emotional and behavioural alterations. This study, as far as we know, is the first one to explore the psychological consequences of lockdown in minors while it was taking place, with them being the ones directly assessed.
Evaluasi Sistem Pengelolaan Limbah Medis dan Zat Berbahaya di RS XXX
Authors: . Muflikun 
Published: October 2020

<p>Rumah Sakit adalah institusi pelayanan kesehatan yang berpotensi menghasilkan limbah cukup banyak. Limbah rumah sakit mencakup semua buangan yang berasal dari kegiatan rumah sakit dalam bentuk padat, cair, pasta (gel) maupun gas yang mengandung mikroorganisme, bahan kimia beracun, dan bersifat <em>radio aktif. </em>Pengelolaan limbah di setiap rumah sakit mengacu pada Kemenkes RI No.1204/Menkes/SK/X/2004. Pengelolaan dimulai sejak pemilahan, pengangkutan dan pemusnahan. Untuk mengevaluasi sistem pengolahan sampah dan bahan berbahaya di rumah sakit XXX. Penelitian ini kuantitatif dengan pendekatan <em>observasi. </em>Populasi yang digunakan dalam penelitian ini yaitu pimpinan dan seluruh petugas pengelola sampah. Sampel penelitian ini ialah seluruh populasi yang mempunyai peran dalam pengelolaan sampah. Analisis yang digunakan adalah data hasil dari wawacara dan <em>checklist </em>hasil observasi. Pelaksanaan prosedur pengolahan limbah sebagian besar sudah dilakukan semua. Pada tahap pemilihan, pengumpulan, pengangkutan dan penyimpanan limbah medis benda tajam, pengolahan dan pemusnahan, pencatatan dan pelaporan masih ada beberpa syarat yang belum terlaksana. Pelengkapan dokumen pengolahan limbah diketahui sudah ada semua dan tersedia dengan lengkap. Analisa pengelolaan sampah diketahui sebagian besar sudah terlaksana. Namun pada indikatror sarana prasarana, petugas kebersihan, perlakuan terhadap limbah dan tanda peringatan sebagian besar belum dilakukan secara menyeluruh. Pelaksanaan prosedur pengolahan limbah dan pengelolaan sampah di rumah sakit XXX belum sesuai dengan Persyaratan Kesehatan Lingkungan Rumah Sakit dan Pengelolaan Limbah Bahan Berbahaya dan Beracun (B3). Kelengkapan dokumen pengolahan limbah medis ada dan sudah tersedia dengan lengkap.</p><p><strong>Kata kunci:</strong> Sistem Pengolahan Limbah dan Zat Berbahaya</p><p> </p>