bluuebunny/crossref_metadata_2025_split huggingface dataset:
Appraisal of the overburden mass and boundary conditions on the rocking behaviour of the vertical spanning strip wall
Authors: Vlachakis Georgios , Colombo Carla , Vecchio Dario , Giouvanidis Anastasios I. , Lourenço Paulo B. 
Published: December 2024

AbstractUnreinforced masonry structures are particularly vulnerable to seismic events. Specifically, local out-of-plane mechanisms form recurrently, posing a serious threat of collapse. Among them, a Vertical Spanning Strip Wall (VSSW) mechanism occurs when a portion of a wall is solely constrained at its top and base, experiencing out-of-plane bending across its height. During the formation of the mechanism and up to collapse, the VSSW presents a highly nonlinear dynamic behaviour governed by the presence of an overlying wall or diaphragm and a diversity of diaphragm-to-wall connections. The present work simulates the dynamics of a VSSW, accounting for the influence of the overburden mass and a variety of boundary conditions through a two-rigid-body single-degree-of-freedom model. In addition, this study examines the energy losses of the VSSW and provides closed-form expressions to estimate the angular coefficient of restitution either analytically for predictive purposes or experimentally for characterisation campaigns. Finally, a series of illustrative comparative free- and forced-rocking analyses highlight the importance of the overburden mass and boundary conditions on the dynamic stability of the VSSW.
The sequential search model: A framework for empirical research
Authors: Ursu Raluca , Seiler Stephan , Honka Elisabeth 
Published: December 2024

Abstract
We provide a detailed overview of the empirical implementation of the sequential search model proposed by Weitzman (1979). We discuss the assumptions underlying the model, the identification of search cost and preference parameters, elasticities and welfare formulas, and different estimation approaches. The goal of this paper is to consolidate knowledge and provide a unified treatment of various aspects of sequential search models that are relevant for empirical work.
Behavioral Measurement as Centerpiece
Authors: Johnston James M. 
Published: December 2024

AbstractHank Pennypacker’s interest in behavioral measurement began early in his career and gradually became the centerpiece of his diverse accomplishments. A review of his focus in the 1960s is followed by a brief summary of the evolution of behavioral measurement practices in applied behavior analysis as it emerged from the field’s laboratory history. This examination serves as pretext for a discussion of the contributions of Strategies and Tactics of Human Behavioral Research (Johnston & Pennypacker, 1980), Strategies and Tactics of Behavioral Research (Johnston & Pennypacker, 1993a, 2009), and Strategies and Tactics of Behavioral Research and Practice (Johnston et al., 2020) to emerging matters of behavioral measurement. That discussion focuses on how issues raised by the challenges of applied research and practice have evolved.
Controlling the mechanical properties of laser powder bed fusion manufactured AlSi10Mg using optimized oscillating scan paths
Authors: Meyer Samuel , Englert Lukas , Schüßler Philipp , Schulze Volker , Dietrich Stefan 
Published: December 2024

AbstractIn the field of metal additive manufacturing, laser powder bed fusion (L-PBF) stands out for its maturity. The path the laser takes over the powder, in this study AlSi10Mg, is determined by a large set of separate parameters; the combination of which offers ample room for optimization. The close ties between the parameters chosen, and the resulting mechanical properties, are what motivates the extensive research done in this field. This study changed the scan line path into a circular oscillation (prolate trochoid) and narrows down a large set of parameters to two sets that exhibit significant differences from traditional scan lines in terms of density, porosity distribution, tensile strength, elongation at fracture, hardness, surface roughness, and melt pool (MP) shape. Remarkable upper bounds for MP size were also characterized for the first time in this work. Some of the noteworthy findings consist of an up to 70% reduction in surface roughness, up to a 40% increase in the elongation at fracture, and up to a $${150}\,{\upmu }\textrm{m}$$

150

μ
m

range of hatching distances to produce a part with under 0.5% porosity. The last of which leads to an overall increase in the robustness of the L-PBF manufacturing process by reducing the sensitivity to parameter fluctuations.
Developing a Smart Energy Service Canvas
Authors: Günter Jennifer , Fabri Lukas , Wenninger Simon , Kaymakci Can 
Published: December 2024

AbstractRising energy and CO2 prices are driving industrial companies to focus increasingly on energy efficiency and flexibility to remain competitive. Besides technical improvements, smart energy services like nonintrusive load monitoring (NILM) are promising approaches to increasing a company’s energy efficiency and flexibility potential. Despite its advantages, smart energy services are not yet widely used in practice, and service providers are cautious. Existing research investigates almost exclusively technical aspects of smart energy service applications and systems, particularly for NILM, while a business model perspective is missing. This study addresses this research gap following a design science research approach with literature research and expert interviews, and develops a business model framework—the Smart Energy Service Canvas (SESC). The SESC is a practical and empirically validated tool to formalize, structure, and implement a business idea on smart energy services.
Banned
Authors: Cabrera Nolan L. , Chang Robert S. 
Published: December 2024

In Banned, readers are taken on a journey through the intense racial politics surrounding the banning of Mexican American Studies in Tucson, Arizona. This book details the state-sponsored racism that led to the elimination of this highly successful program, and the grassroots and legal resistance that followed. Through extensive research and firsthand narratives, readers will gain a deep understanding of the controversy surrounding this historic case. The legal challenge successfully overturned the Arizona law and became a central symbol in the modern-day Ethnic Studies renaissance. This work is a must-read for anyone interested in understanding the power of community activism, the importance of fighting for educational equity, and why the example of Tucson created an alternative blueprint for how we can challenge states that are currently banning critical race theory.
Development of a multifunctional optical diagnostic system at the Shenguang-II upgrade laser facility
Authors: Li Xinyan , Yuan Peng , Gao Fan , Liu Yifan , Wu Lixuan , Yuan Xiaohui , Zhang Zhe , Zhang Jie , Li Jun , Zheng Jian 
Published: December 2024

Abstract
A multifunctional optical diagnostic system, which includes an interferometer, a refractometer and a multi-frame shadowgraph, has been developed at the Shenguang-II upgrade laser facility to characterize underdense plasmas in experiments of the double-cone ignition scheme of inertial confinement fusion. The system employs a 266 nm laser as the probe to minimize the refraction effect and allows for flexible switching among three modes of the interferometer, refractometer and multi-frame shadowgraph. The multifunctional module comprises a pair of beam splitters that attenuate the laser, shield stray light and configure the multi-frame and interferometric modules. By adjusting the distance and angle between the beam splitters, the system can be easily adjusted and switched between the modes. Diagnostic results demonstrate that the interferometer can reconstruct electron density below 1019 cm–3, while the refractometer can diagnose density approximately up to 1020 cm–3. The multi-frame shadowgraph is used to qualitatively characterize the temporal evolution of plasmas in the cases in which the interferometer and refractometer become ineffective.
Essay review: the fictive history of Victorian science and empire
Authors: Steere-Williams Jacob 
Published: December 2024

In 1820 two French scientists – Pierre Joseph Pelletier and Jean Bienaimé Caventou – discovered and named the active alkaloid substance extracted from cinchona bark: quinine. The bark from the ‘wondrous’ fever tree, and its antimalarial properties, however, had long been known to both colonial scientists and indigenous Peruvians. From the mid-seventeenth century, cinchona bark, taken from trees that grow on the eastern slopes of the Andes, was part of a global circulation of botanical knowledge, practice and profit. By the 1850s, Europeans eager to bypass South American trade routes to access cinchona plants established plantations across the global South in French Algeria, Dutch Java and British India. Wardian cases – plant terrariums named after British physician Nathaniel Bagshaw Ward – would fuel new imperial efforts to curb malaria, contemporaries argued. And yet cinchona trees proved difficult to transport over land and sea, and did not easily or universally thrive in new tropical climates. As a result of the growing demand and uncertainty around cinchona, as Pratik Chakrabarti has argued, from the late eighteenth century there was ‘a global scientific obsession’ with finding a ‘substitute’ for cinchona, particularly local alternatives in India and China.1
Failure to Launch: Tracing the Trajectory of Democratic Innovation Adoption in Canada
Authors: Mattes Megan , Massie Joanna 
Published: December 2024

Abstract
Canada is regarded as an early adopter of democratic innovations, including the high-profile BC Citizens’ Assembly on Electoral Reform. To what extent has Canada maintained this trajectory? We examine this in the context of breadth and depth by examining trends in adoption over time across Canada and case-level adoption according to the dimensions of influence and temporality. While case studies of Canadian democratic innovations exist, these do not provide analytical capacity to understand trends in the breadth of adoption; we thus contribute a novel dataset of democratic innovations in Canada from 2000 to 2020. To analyze the depth of adoption, we present a two-by-three framework, which we apply to interpret our dataset of Canadian democratic innovations. We find that while there is an increase in the total number of democratic innovations, a low quantity is observed that exhibits high influence and permanence.
Camel tick species distribution in Saudi Arabia and United Arab Emirates using MaxEnt modelling
Authors: Perveen Nighat , Muzaffar Sabir B. , Jaradat Areej , Sparagano Olivier A. , Willingham Arve L. 
Published: December 2024

AbstractTicks are important vectors and reservoirs of pathogens causing zoonotic diseases in camels and other livestock, rodents and other small mammals, birds and humans. Hyalomma dromedarii is the most abundant tick species in Saudi Arabia and United Arab Emirates (UAE) affecting primarily camels, and to a lesser extent, other livestock. Species presence data, land use/landcover, elevation, slope and 19 bioclimatic variables were used to model current and future distribution of H. dromedarii ticks using maximum entropy species distribution modelling (MaxEnt.). The model highlighted areas in the northern, eastern and southwestern parts of the study area as highly suitable for ticks. Several variables including land use/land cover (LULC) (53.1%), precipitation of coldest quarter (Bio19) (21.8%), elevation (20.6%), isothermality (Bio3) (1.9%), mean diurnal range [mean of monthly (max temp – min temp)] (Bio2) (1.8%), slope (0.5%), precipitation, seasonality (Bio15) (0.2%) influenced habitat suitability of ticks, predicting high tick density or abundance. Middle of the road scenario (ssp2-4.5) where CO2 levels remain similar to current levels, did not indicate a major change in the tick distributions. This tick distribution model could be used for targeting surveillance efforts and increasing the efficiency and accuracy of public health investigations and vector control strategies.
Networks of care for the modern adolescent
Authors: White Simon R. , Soneson Emma ,   OxWell Study Team, Fazel Mina 
Published: December 2024

AbstractBackgroundAt a time of increased demand for specialist mental health services, a more nuanced understanding of how adolescents navigate systems of care and support is essential. We mapped ‘networks of care’ to explore patterns of mental health help-seeking alongside the perceived helpfulness of support accessed.MethodsWe examined data from 23 927 adolescents aged 11–18 years who participated in the 2023 OxWell Student Survey, an English school-based, repeated cross-sectional survey of mental health and wellbeing. Students self-reported past-year access to 18 types of support across informal (e.g. friends and family), semi-formal (e.g. school and charities), and formal (e.g. health and social care) domains, alongside how helpful they found the support. We used a network approach to explore interconnections between sources of support accessed and perceived helpfulness.ResultsOne in four (27.0%, 6449/23927) adolescents reported past-year access to mental health support, of which 56.7% (3658/6449) reported accessing multiple types. Informal networks were the most commonly accessed (23.1%, 5523/23927), followed by semi-formal (9.7%, 2317/23927) and formal (6.8%, 1623/23927) supports. Informal sources had high acceptability, with around 80–90% reporting them as helpful, whereas child and adolescent mental health services (CAMHS), helplines, and online supports were perceived to be the least helpful. The networks also identified groups who might not be optimally served by current systems, including gender diverse adolescents and adolescents who found mental health support from their parents unhelpful.ConclusionsAdolescents are accessing mental health support across informal, semi-formal, and formal sources of care. Services can no longer be developed, delivered, or evaluated in isolation from these networks.
On a Mertens-type conjecture for number fields
Authors: HU DANIEL , KANEKO IKUYA , MARTIN SPENCER , SCHILDKRAUT CARL 
Published: December 2024

AbstractWe introduce a number field analogue of the Mertens conjecture and demonstrate its falsity for all but finitely many number fields of any given degree. We establish the existence of a logarithmic limiting distribution for the analogous Mertens function, expanding upon work of Ng. Finally, we explore properties of the generalised Mertens function of certain dicyclic number fields as consequences of Artin factorisation.
Constrictive pericarditis following epicardial pacemaker implant: a diagnostic dilemma
Authors: Khan Naveed , Sen Supratim , Kumar Gaurav 
Published: December 2024

AbstractConstrictive pericarditis is a rare complication after cardiac surgery. It is mostly seen in adults. We report a case of constrictive pericarditis in a 3-year-old child with right ventricular dysfunction after permanent pacemaker implantation during infancy for congenital complete heart block. Suspicion of constrictive pericarditis must be kept in mind during evaluation.
Bridging the Gap Between Global Weather Prediction and Global Storm‐Resolving Simulation: Introducing the GFDL 6.5‐km SHiELD
Authors: Zhou Linjiong , Harris Lucas , Chen Jan‐Huey , Gao Kun , Cheng Kai‐Yuan , Tong Mingjing , Kaltenbaugh Alex , Morin Matthew , Mouallem Joseph , Chilutti Lauren , Johnston Lily 
Published: December 2024

AbstractWe introduce a 6.5‐km version of the Geophysical Fluid Dynamics Laboratory (GFDL)'s System for High‐resolution prediction on Earth‐to‐Local Domains (SHiELD). This global model is designed to bridge the gap between global medium‐range weather prediction and global storm‐resolving simulation while remaining practical for real‐time forecast. The 6.5‐km SHiELD represents a significant advancement over GFDL's flagship global forecast system, the 13‐km SHiELD. This global model features a holistically‐developed scale‐aware suite of physical parameterizations, stepping into the formidable convective “gray zone” of resolutions below 10 km. Comparative analyses with the 13‐km SHiELD, conducted over a 3‐year hindcast period, highlight noteworthy improvements across global‐scale, regional‐scale, tropical cyclone (TC), and continental convection predictions. In particular, the 6.5‐km SHiELD excels in predicting considerably finer‐scale convective systems associated with large‐scale frontal systems and extratropical cyclones. The predictions of global temperature, wind, cloud, and precipitation are significantly improved in this global model. Regionally, over the contiguous United States and the Maritime Continent, substantial reductions in prediction biases of precipitation, cloud cover, and wind fields are also found. In the mesoscale realm, the model demonstrates prominent improvements in global TC intensity and continental convective precipitation prediction: biases are relieved, and skill is higher. These findings affirm the superiority of the 6.5‐km SHiELD compared to the current 13‐km SHiELD, which will advance weather prediction by successfully addressing both synoptic weather systems and specific storm‐scale phenomena in the same global model.
OXTR-mediated signaling in astrocytes contributes to anxiolysis
Authors: Meinung Carl-Philipp , Boi Laura , Pandamooz Sareh , Mazaud David , Ghézali Grégory , Rouach Nathalie , Neumann Inga D. 
Published: December 2024

AbstractAstrocytes are an indispensable part of signal processing within the mammalian brain. Thus, the mode of action of a neuropeptide such as oxytocin (OXT) can only be fully understood considering this integral part of the CNS. Here, we show that OXT regulates astrocytic gene expression, intracellular signaling and specific proteins both in vitro and in vivo. This translates into rapid regulation of astroglial structural and functional properties including cytoskeletal plasticity, coverage of synapses and gap-junction coupling. At the molecular level, we identify the previously undescribed Sp1-Gem signaling cascade as the key driver for these cell type-specific OXT effects. Finally at the behavioral level, we found in vivo that OXT requires astrocytes to exert its well described anxiolytic properties within the hypothalamic paraventricular nucleus. Thus, our study points to OXT receptor-expressing astrocytes as a critical component of the brain OXT system.
A phase 2 pilot study of umbilical cord blood infusion as an adjuvant consolidation therapy in elderly patients with acute myeloid leukemia
Authors: Wang Jinzeng , Li Xiaoyang , Liu Ping , Dai Yao , Zhu Hongming , Zhang Yunxiang , Wu Min , Yao Yunying , Liu Mingzhu , Yu Shuting , Jiang Fangying , Wang Shuai , Mu Haoran , Jiao Bo , Yan Hua , Wu Wen , Shen Yang , Li Junming , Wang Shengyue , Ren Ruibao 
Published: December 2024

AbstractAcute myeloid leukemia (AML) is an aging-related malignancy, with patients aged ≥60 years old facing significantly poorer prognosis. Umbilical cord blood (UCB) has emerged as a promising source with effective anti-aging roles. Here, we conducted a prospective, phase 2, single-arm trial of UCB infusion as an adjuvant consolidation therapy in elderly AML patients (ChiCTR-OPC-15006492). A total of 51 patients were enrolled (median age 66 years; range, 60–75) and received two cycles of consolidation chemotherapy combined with UCB infusion. At a median follow-up of 27.3 months (range, 9.3–100), the median overall survival (OS) was not yet reached and the median event-free survival (EFS) was 72.2 months (range, 5.4–100). The 2-year OS and EFS rates were 76.9% and 62.8%, respectively. No acute graft-versus-host disease (aGVHD) or toxicity-related death occurred in any patient. The median times to platelet and neutrophil recovery were 11.5 days (range, 6–17) and 12.2 days (range, 0–21), respectively. Single-cell RNA sequencing (scRNA-seq) identified enhanced anti-tumor and anti-aging properties of UCB, manifested through activation of immune responses and telomere synthesis/maintenance. These findings suggest that UCB infusion is an effective and safe post-remission adjuvant therapy for elderly AML patients. This study provides evidence that anti-aging therapy may serve as a new and promising dimension in combined cancer treatment.
Comparison of fludarabine/melphalan (FM140) with fludarabine/melphalan/BCNU (FBM110) in patients with relapsed/refractory AML undergoing allogeneic hematopoietic cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party
Authors: Duque-Afonso Jesús , Finke Jürgen , Ngoya Maud , Galimard Jacques-Emmanuel , Schetelig Johannes , Eder Matthias , Rösler Wolf , Bug Gesine , Neubauer Andreas , Edinger Matthias , Wulf Gerald. G. , Jindra Pavel , Einsele Hermann , Stelljes Matthias , Selleslag Dominik , Wagner-Drouet Eva Maria , Bunjes Donald , Spyridonidis Alexandros , Brissot Eolia , Nagler Arnon , Ciceri Fabio , Mohty Mohamad 
Published: December 2024

AbstractThe treatment of relapsed/refractory acute myeloid leukemia (AML) is associated with a dismal prognosis. The allogeneic hematopoietic cell transplantation (allo-HCT) is frequently performed as salvage therapy. Reduced intensity conditioning protocols have been developed with the aim of reducing the leukemia burden without increasing their toxicity. We compared the reduced intensity conditioning FM140 (fludarabine, 150 mg/m2; melphalan 140 mg/m2) with FBM110 (fludarabine 150 mg/m2; BCNU, also known as carmustine, 300–400 mg/m2; and melphalan 110 mg/m2). From the European Bone Marrow Transplantation (EBMT) Acute Leukemia Working Party registry, we identified 293 adult patients (FM140, n = 118 and FBM110, n = 175) with AML with relapsed/refractory disease prior to allo-HCT. There were some differences such as age (FM140 = 59.5 years vs. FBM110 = 65.1 years, p < 0.001) and graft-versus-host disease (GvHD) prophylaxis based on in vivo T-cell depletion (TCD, FM140 = 39% vs. FBM110 = 75%, p < 0.001). No differences were observed between FM140- and FBM110-treated patients regarding overall survival (OS) (2-year OS: 39.3% vs. 45.7%, p = 0.58), progression-free survival (PFS) (2-year PFS: 36.1% vs. 37.3%, p = 0.69), non-relapse mortality (NRM) (2-year NRM: 15.3% vs. 25.7%, p = 0.10) and relapse incidence (RI) (2-year RI: 48.6% vs. 37.0%, p = 0.7). In conclusion, despite differences in age and GvHD prophylaxis, AML patients with active disease undergoing allo-HCT after FBM110 conditioning showed similar outcomes compared to FM140.
17β-estradiol alleviated ferroptotic neuroinflammation by suppressing ATF4 in mouse model of Parkinson’s disease
Authors: Wang Guoming , Zhuang Wenxin , Zhou Yijun , Wang Xu , Li Zhenfeng , Liu Chuanliang , Li Wentong , He Maotao , Lv E. 
Published: December 2024

AbstractNeuroinflammation induced by activation of microglial is a vital contributor to progression of Parkinson’s disease (PD), emerging evidences suggested that ferroptosis played a pivotal role in microglial activation and subsequent dopaminergic neuron loss. Nevertheless, the fundamental pathogenesis of that ferroptosis contributes to PD is not yet sufficiently understood. Based on GEO dataset, ferroptosis related genes were found to be enriched in PD patients and MPTP mouse model of PD, among them, ATF4 was found to be dramatically differentially expressed. In our study, ectopic expression of ATF4 augmented MPP+-induced cytotoxic and activation of BV2 cells with upregulated intracellular L-ROS, TLR4 and pNF-κB. Ectopic ATF4 effectively promoted transformation of microglial into M1 pro-inflammatory phenotype. 17β-estradiol (E2) attenuated expression of ATF4 in BV2 cells, silence of ATF4 enhanced protective effect of E2 on MPP+-treated BV2 cells. In MPTP-induced PD mouse model, administration of E2 further abated expression of ATF4 and inhibited expressions of pro-inflammatory cytokines and activation of TLR4/NF-κB pathway. Overall, E2 effectively counteracted TLR4/NF-κB signaling pathway by restraining ATF4 and inhibited inflammatory response triggered by ferroptosis, ultimately exerted anti-PD effects.