bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Prostate Cancer on Erectile Dysfunction in Northern Cameroon and Its Management
Authors: Simo Richard Tagne , Cheunieu Carmelle Noubissie , Ahmadou Mohamadou , Baiguerel Erika Myriam , Kamdje Armel Hervé Nwabo , Sillong Franklin Danki , Telefo Phelix Bruno 
Published: December 2020

Due to the lack of hospitals with adequate technical platform on one hand, and high diagnostic costs that cannot be afforded most of the population, the incidence of prostate cancer in Cameroon has increased and has great impact on people’s health.
Aim: This work was undertaken with the objective to determine the impact of prostate cancer on erectile dysfunction and how to manage it.
Methodology: Sampling of the population was done in a comprehensive and non-probabilistic manner at the Urology Department of Ngaoundere Islamic Hospital, Ngaoundere, Cameroon, between June 2018 and November 2019. Of the 75 patients received, 50 of them participated in this study. Biopsies were taken from these patients to determine and confirm the form and stage of cancer followed by PSA assays. After the diagnosis was revealed, the testosterone assay was carried out in order to evaluate erectile functioning in the patients who equally completed a survey form made available to them in order to get an idea of their health history, the type of treatment followed and their lifestyle.
Results: The mean age of the patients was 67 years, with a predominance in the 60-70 age range. 85% of the patients had a Gleason score greater than or equal to 8. Of these patients, 42% had low testosterone levels (< 2.3 ng/mL), resulting to lack of morning erection (66.6%), loss of sexual desire (43.9%), difficulty having a spontaneous erection (88%). On the other hand, erectile dysfunction was revealed in the prostate cancer patients with low testosterone levels, with a history of hypertention (16.6%), diabetes (28.5%) alcohol consumption (44%), tobacco smoking (41%) and having undergone as prostate cancer treatment involving transurethral resection of the prostate (80%) and orchiectomy (20%).
Conclusion: The major cause of erectile dysfunction observed in patients suffering from prostate cancer in Northen Cameroon can be attributed to the evolution of the disease, as well as the health history of the patients (diabetes, hypertension).
Microbiological Research of the Effects of Electromagnetic Fields of the Bacteria Escherichia coli, Enterococci, Coliforms and Clostridium perfringens
Authors: Valcheva Nedyalka , Ignatov Ignat 
Published: December 2020

The aim of the study was to analyze the microbiological effects of electromagnetic fields with method of Drossinakis with reliable microbiological methods. A comparative analysis of the number of bacteria of a given species before and after electromagnetic influence was performed. For the research was applied water with the following bacteria –Escherichia coli, Enterococci, Coliforms and Clostridium perfringens.
The method of Drossinakis is including the electromagnetic waves in the electromagnetic spectrum, from 1 Hz to 3.1015 Hz. For the inhibiting effects on bacteria the method of Drossinakis is including low frequencies from 20 till 70 Hz.
The study shows the effects with low frequencies electromagnetic waves for decreasing of the number of bacteria. The controlled microbiological parameters are defined by the membrane method and by using of differential diagnostic nutrient media at 24 hours.
Identification of the fatty acid coenzyme‐A ligase FadD1 as an interacting partner of FptX in the Pseudomonas aeruginosa pyochelin pathway
Authors: Roche Béatrice , Mislin Gaëtan L. A. , Schalk Isabelle J. 
Published: December 2020

Pseudomonas aeruginosa is one of the most important nosocomial bacteria emerging as a highly multidrug‐resistant pathogen. P. aeruginosa produces two siderophores including pyochelin (PCH) to fulfil its need for iron during infections. We know that both outer and inner membrane proteins FptA and FptX are involved in the ferri‐PCH uptake, but this process requires increasing molecular and biochemical knowledge. Here, using bacterial two‐hybrid and copurification assays we identified the fatty acid coenzyme‐A ligase FadD1 as a novel interacting partner of the inner membrane transporter FptX and found that FadD1 may play a role in PCH production. We managed to purify the FadD1–FptX inner membrane complex and obtained low‐resolution 3D models, opening the way for future high‐resolution structures.
Clinical perspectives and concerns of metformin as an anti‐aging drug
Authors: Wang Chuyao , Chen Bangwei , Feng Qian , Nie Chao , Li Tao 
Published: December 2020

AbstractAs percentages of elderly people rise in many societies, age‐related diseases have become more prevalent than ever. Research interests have been shifting to delaying age‐related diseases by delaying or reversing aging itself. We use metformin as an entry point to talk about the important molecular and genetic longevity‐regulating mechanisms that have been extensively studied with it. Then we review a number of observational studies, animal studies, and clinical trials to reflect the clinical potentials of the mechanisms in lifespan extension, cardiovascular diseases, tumors, and neurodegeneration. Finally, we highlight remaining concerns that are related to metformin and future anti‐aging research.
Venetoclax with decitabine vs intensive chemotherapy in acute myeloid leukemia: A propensity score matched analysis stratified by risk of treatment‐related mortality
Authors: Maiti Abhishek , Qiao Wei , Sasaki Koji , Ravandi Farhad , Kadia Tapan M. , Jabbour Elias J. , Daver Naval G. , Borthakur Gautam , Garcia‐Manero Guillermo , Pierce Sherry A. , Montalbano Kathryn S. , Pemmaraju Naveen , Naqvi Kiran , Ohanian Maro , Short Nicholas J. , Alvarado Yesid , Takahashi Koichi , Yilmaz Musa , Jain Nitin , Kornblau Steven M. , Andreeff Michael , Bose Prithviraj , Ferrajoli Alessandra , Issa Ghayas C. , Masarova Lucia , Thompson Philip A. , Rausch Caitlin R. , Ning Jing , Kantarjian Hagop M. , DiNardo Courtney D. , Konopleva Marina Y. 
Published: December 2020

AbstractHypomethylating agents (HMA) with venetoclax is a new standard for older/unfit patients with acute myeloid leukemia (AML). However, it is unknown how HMA with venetoclax compare to intensive chemotherapy (IC) in patients who are “fit” or “unfit” for IC. We compared outcomes of older patients with newly diagnosed AML receiving 10‐day decitabine with venetoclax (DEC10‐VEN) vs IC. DEC10‐VEN consisted of daily venetoclax with decitabine 20 mg/m2 for 10 days for induction and decitabine for 5 days as consolidation. The IC cohort received regimens containing cytarabine ≥1 g/m2/d. A validated treatment‐related mortality score (TRMS) was used to classify patients at high‐risk or low‐risk for TRM with IC. Propensity scores were used to match patients to minimize bias. Median age of the DEC10‐VEN cohort (n = 85) was 72 years (range 63‐89) and 28% patients were at high‐risk of TRM with IC. The comparator IC group (n = 85) matched closely in terms of baseline characteristics. DEC10‐VEN was associated with significantly higher CR/CRi compared to IC (81% vs 52%, P < .001), and lower rate of relapse (34% vs 56%, P = .01), 30‐day mortality (1% vs 24%, P < .01), and longer overall survival (OS; 12.4 vs 4.5 months, HR = 0.48, 95%CI 0.29‐0.79, P < .01). In patients at both at high‐risk and low‐risk of TRM, DEC10‐VEN showed significantly higher CR/CRi, lower 30‐day mortality, and longer OS compared to IC. Patients at both high‐risk and low‐risk of TRM had comparable outcomes with DEC10‐VEN. In conclusion, DEC10‐VEN offers better outcomes compared to intensive chemotherapy in older patients with newly diagnosed AML, particularly in those at high‐risk of TRM.
Pyrene‐fused Dibenzoazatetracenes: Synthesis, Crystal Structures, Photophysical Properties and their Morphologies
Authors: Wang Qingsong , Gao Wei , Chen Yan , Wang Xiaohui , Zeng Jin , Liu Yiwei , Ran Huijuan , Hu Zhen , Bai Jie , Feng Xing , Redshaw Carl , Chen Qing , Hu Jian‐Yong 
Published: December 2020

AbstractMolecular packing and microstructure can play a crucial role in the photophysical and electronic properties of organic semiconductor materials. This article presents six pyrene‐fused dibenzoazatetracenes 3 and the relationship between their molecular structures and the emission, and as well as the morphology has been investigated. All of the compounds display an aggregation‐caused emission quenching effect due to the extended π‐conjugation associated with the close π‐π stacking in their crystal structures. In terms of fluorescence, the compounds emitted sky‐blue emission with a maximum peak (λmaxem) in the range 469–474 nm with a quantum yield (Φf) of 0.37–0.50 in solution. In the solid state, the emission maximum red‐shifts to ∼528 nm and possesses a relatively low quantum yield (<0.16). In addition, the electronic effects of the terminal group shows only a limited effect on the emission behavior. On the other hand, tert‐butyl groups have been introduced at the pyrene core, and contribute to enhance the solubility of the compound, and also improve the quality of the morphology.
Cardiotoxicity of immune checkpoint inhibitors: An updated review
Authors: Behravesh Soheil , Shomali Navid , Danbaran Gholamreza Rezaei , Aslani Saeed , Hemmatzadeh Maryam , Hosseinzadeh Ramin , Gowhari‐Shabgah Arezoo , Mohammadi Hamed 
Published: December 2020

AbstractThe immune checkpoint molecules are involved in the regulation of T cells in order to prevent them from attacking to sell tissues and play a role in the immune response homeostasis. Application of the immune checkpoint inhibitors (ICIs) has provided a promising therapeutic approach in pathologies where the immune system is suppressed. The extended utilization of ICIs in several cancers has caused immune‐related side effects in the cardiovascular system like cardiomyopathy and myocarditis. Cardiac toxicity, one of the main side effects of the ICIs‐based therapeutic approach, has less been concerned; however, during the last years, many cases of fatal heart failure and myocarditis have been reported in patients treated with ICIs. In this review article, we attempted to discuss the cardiac adverse effects of inhibiting different immune checkpoint molecules.
Modulation of cytokine production by monocytes and developing‐dendritic cells under the influence of leukemia and lymphoma cell products
Authors: Motta Juliana Maria , Rumjanek Vivian Mary 
Published: December 2020

AbstractCytokines and other soluble factors released by tumor cells play an important role in modulating immune cells to favor tumor development. Monocyte differentiation into macrophages or dendritic cells (DCs) with specific phenotypes is deeply affected by tumor signals and understanding this context is paramount to prevent and propose new therapeutic possibilities. Hence, we developed a study to better describe the modulatory effects of leukemia and lymphoma cell products on human monocytes and monocyte‐derived DCs secretion of cytokines such as interleukin (IL)‐1β, tumor necrosis factor‐α (TNF‐α), IL‐6, and IL‐12. Except with the promyelocytic leukemia cell supernatants (HL‐60), the other two tumor supernatants (chronic myeloid leukemia, K562 and Burkitt lymphoma, DAUDI) increased both TNF‐α and IL‐1β production by monocytes and monocytes undergoing differentiation. This effect was neither explained by alterations of cell number in culture nor by the high amount of vascular endothelial growth factor (VEGF) present in the tumor supernatants. Moreover, all supernatants used were able to induce drastic reduction of IL‐12 secretion by cells induced to activation, suggesting a negative interference with Th1 antitumoral responses that should be a huge advantage for tumor progression.
Dysregulation of the immune response in coronavirus disease 2019
Authors: Mohamed Khosroshahi Leila , Rezaei Nima 
Published: December 2020

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can trigger a cytokine storm in the pulmonary tissue by releasing various types of mediators, leading to acute respiratory distress syndrome (ARDS). Increased neutrophil‐to‐lymphocyte ratio, as well as CD4+ T lymphopenia, is reported in cases with novel coronavirus disease (COVID‐19), meanwhile, lymphopenia is a significant finding in the majority of COVID‐19 cases with a severe phenotype. Moreover, excessive activation of monocyte/macrophage and cytokine storms are associated with the severity of the disease and the related complications in SARS‐CoV‐2 infection. Understanding the immune response dysregulation in COVID‐19 is essential to develop more effective diagnostic, therapeutic, and prophylactic strategies in this pandemic.
Proton‐Functionalized Graphitic Carbon Nitride for Efficient Metal‐Free Destruction of Escherichia coli under Low‐Power Light Irradiation
Authors: Ng Boon‐Junn , Musyaffa Muhammad Khosyi , Er Chen‐Chen , Packiam Kulandai Arockia Rajesh , Lee W. P. Cathie , Tan Lling‐Lling , Lee Hing Wah , Ooi Chien Wei , Chai Siang‐Piao 
Published: December 2020

AbstractUniversal access to clean water has been a global ambition over the years. Photocatalytic water disinfection through advanced oxidation processes has been regarded as one of the promising methods for breaking down microbials. The forefront of this research focuses on the application of metal‐free photocatalysts for disinfection to prevent secondary pollution. Graphitic carbon nitride (g‐C3N4) has achieved instant attention as a metal‐free and visible‐light‐responsive photocatalyst for various energy and environmental applications. However, the photocatalytic efficiency of g‐C3N4 is still affected by its rapid charge recombination and sluggish electron‐transfer kinetics. In this contribution, two‐dimensionally protonated g‐C3N4 was employed as metal‐free photocatalyst for water treatment and demonstrated 100 % of Escherichia coli within 4 h under irradiation with a 23 W light bulb. The introduction of protonation can modulate the surface charge of g‐C3N4; this enhances its conductivity and provides a “highway” for the delocalization of electrons. This work highlights the potential of conjugated polymers in antibacterial application.
Design and Synthesis of DDR1 Inhibitors with a Desired Pharmacophore Using Deep Generative Models
Authors: Yoshimori Atsushi , Asawa Yasunobu , Kawasaki Enzo , Tasaka Tomohiko , Matsuda Seiji , Sekikawa Toru , Tanabe Satoshi , Neya Masahiro , Natsugari Hideaki , Kanai Chisato 
Published: December 2020

AbstractDiscoidin domain receptor 1 (DDR1) inhibitors with a desired pharmacophore were designed using deep generative models (DGMs). DDR1 is a receptor tyrosine kinase activated by matrix collagens and implicated in diseases such as cancer, fibrosis and hypoxia. Herein we describe the synthesis and inhibitory activity of compounds generated from DGMs. Three compounds were found to have sub‐micromolar inhibitory activity. The most potent of which, compound 3 (N‐(4‐chloro‐3‐((pyridin‐3‐yloxy)methyl)phenyl)‐3‐(trifluoromethyl)benzamide), had an IC50 value of 92.5 nM. Furthermore, these compounds were predicted to interact with DDR1, which have a desired pharmacophore derived from a known DDR1 inhibitor. The results of synthesis and experiments indicated that our de novo design strategy is practical for hit identification and scaffold hopping.
Individual‐specific functional connectome biomarkers predict schizophrenia positive symptoms during adolescent brain maturation
Authors: Fan Yun‐Shuang , Li Liang , Peng Yue , Li Haoru , Guo Jing , Li Meiling , Yang Siqi , Yao Meng , Zhao Jingping , Liu Hesheng , Liao Wei , Guo Xiaonan , Han Shaoqiang , Cui Qian , Duan Xujun , Xu Yong , Zhang Yan , Chen Huafu 
Published: December 2020

AbstractEven with an overarching functional dysconnectivity model of adolescent‐onset schizophrenia (AOS), there have been no functional connectome (FC) biomarkers identified for predicting patients' specific symptom domains. Adolescence is a period of dramatic brain maturation, with substantial interindividual variability in brain anatomy. However, existing group‐level hypotheses of AOS lack precision in terms of neuroanatomical boundaries. This study aimed to identify individual‐specific FC biomarkers associated with schizophrenic symptom manifestation during adolescent brain maturation. We used a reliable individual‐level cortical parcellation approach to map functional brain regions in each subject, that were then used to identify FC biomarkers for predicting dimension‐specific psychotic symptoms in 30 antipsychotic‐naïve first‐episode AOS patients (recruited sample of 39). Age‐related changes in biomarker expression were compared between these patients and 31 healthy controls. Moreover, 29 antipsychotic‐naïve first‐episode AOS patients (analyzed sample of 25) were recruited from another center to test the generalizability of the prediction model. Individual‐specific FC biomarkers could significantly and better predict AOS positive‐dimension symptoms with a relatively stronger generalizability than at the group level. Specifically, positive symptom domains were estimated based on connections between the frontoparietal control network (FPN) and salience network and within FPN. Consistent with the neurodevelopmental hypothesis of schizophrenia, the FPN–SN connection exhibited aberrant age‐associated alteration in AOS. The individual‐level findings reveal reproducible FPN‐based FC biomarkers associated with AOS positive symptom domains, and highlight the importance of accounting for individual variation in the study of adolescent‐onset disorders.
Physicochemical susceptibility of SARS‐CoV‐2 to disinfection and physical approach of prophylaxis
Authors: Saadatpour Fatemeh , Mohammadipanah Fatemeh 
Published: December 2020

AbstractThe transmission control of the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the most effective strategy by the absence of its specified vaccine or drug. Although the aerosol mediated transmission of SARS‐CoV‐2 has been confirmed, the physicochemical treatment of the biotic and abiotic objects is still the most promising approach in its infection control. The front line of the most effective disinfecting compounds on SARS‐CoV‐2 implies to be sodium hypochlorite, ethanol, hydrogen peroxide, quaternary ammonium compounds, and phenolic compounds, respectively. However, widely used compounds of alkyldimethylbenzylammonium chloride (benzalkonium chloride) biguanides (chlorhexidine) have not shown the multitude load reduction in less than 10 minutes. The susceptibility of SARS‐CoV‐2 to physical treatment follows the pattern of heat, acidity, and UV radiation. Rather all of the mentioned physical or chemical treatments, target the envelope proteins of the coronavirus mainly by impairing its entry to host cells. The anti‐SARS‐CoV‐2 activity of combinatorial physicochemical treatments or evaluation of new chemical entities or physical treatments such as microwave irradiation still needs to be explored. Therefore, the development of a reliable decontamination protocol for SARS‐CoV‐2 demands revealing its stability pattern study vs a spectrum of single and combinatorial physicochemical parameters.
The influence of parental warmth and stress on reading through approaches to learning: Racial/ethnic variation
Authors: Hill Tatiana , Palacios Natalia 
Published: December 2020

AbstractWhen identifying parental socialization processes influencing children's reading achievement, building self‐regulation is a potential underlying mechanism. Yet socialization (i.e., warmth, stress) of self‐regulation may vary based on the sociocultural context of ethnic minority families. Using the ECLS‐K: 2011 (N= 17,020;MAge= 73.43 mos,SD= 4.48 mos), we explored: (RQ1) Do kindergarten approaches to learning (ATL), a composite of self‐regulation behaviours in the classroom context, mediate the association between parental warmth and stress and first grade reading? and (RQ2) Is mediation moderated by race/ethnicity (White, Black, Hispanic, Asian)? ATL mediated the association between parental warmth and stress and reading, such that parental warmth contributed positively to reading through higher ATL, and parental stress contributed negatively to reading through lower ATL. However, the lack of moderation suggests that the adaptiveness of parental warmth and maladaptiveness of parental stress for children's reading through ATL may be similar across race/ethnicity. Findings inform intervention and practice targeting children's school readiness.HighlightsThe current study explored whether parental warmth and stress influenced reading through approaches to learning skills, considering variation by race/ethnicity.The mediation model and conditional process analysis reveal that across race/ethnicity, warmth benefits reading and stress is detrimental for reading.Parental warmth and stress should inform interventions promoting children's school readiness, with attention to cultural practices of ethnically diverse families.
The impact of constitutional property law on insolvency law in South Africa
Authors: Brits Reghard 
Published: December 2020

AbstractIt is common for insolvency legislation to interfere with the property rights of debtors, creditors and third parties in pursuit of its purpose to provide an orderly and fair resolution to insolvency‐related problems. However, the South African property clause, Section 25 of the Constitution, prohibits arbitrary interferences with vested property interests. In light of this, this article focuses on the application of Section 25 to insolvency law in South Africa. The question is whether interferences with property rights in terms of insolvency legislation qualify as deprivations of property for constitutional purposes and, if so, whether they comply with the relevant validity requirements. This article investigates this question by explaining the interaction between insolvency law and constitutional law in general, followed by a closer look at the application and operation of the property clause in particular. Thereafter, three examples from case law are discussed to illustrate the role of constitutional property law in evaluating the effects of insolvency legislation in South Africa. The conclusion is drawn that, as long as the relevant requirements are met, the norms underlying the property clause do not hinder the development and implementation of legitimate and necessary insolvency procedures that could impact on vested property rights.
The impact of financial deepening on income inequality: Empirical evidence from Australia
Authors: Shi Yongfen , Paul Sudeshna , Paramati Sudharshan Reddy 
Published: December 2020

AbstractThe present research paper is designed to explore the role of financial development indicators on income inequality in Australia using yearly data from 1980 to 2014. Our study also accounts for other potential determinants of income inequality such as inflation, per capita income and trade openness. Our results from Bayer and Hanck (2013) cointegration test confirm the long‐run equilibrium relationship across the models. Similarly, the long‐run estimates from the quantile regression models and non‐parametric approach indicate that the financial development indicators, foreign direct investment (FDI) inflows, inflation and trade openness have significant positive impact on income inequality in Australia. However, the growth in per capita income plays the opposite role. Given these findings, our study offers numerous policy and practical implications and adds an important value to the empirical literature on the nexus between financial development and income inequality.