bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and verification of three key genes associated with survival and prognosis of COAD patients via integrated bioinformatics analysis
Authors: Liu Yong , Li Chao , Dong Lijin , Chen Xuewei , Fan Rong 
Published: September 2020

Abstract
Background: Colorectal cancer (CRC) is the third most lethal malignancy in the world, wherein colon adenocarcinoma (COAD) is the most prevalent type of CRC. Exploring biomarkers is important for the diagnosis, treatment, and prevention of COAD. Methods: We used GEO2R and Venn online software for differential gene screening analysis. Hub genes were screened via Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape, following Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Finally, survival analysis and RNA expression validation were performed via UALCAN online software and real-time PCR. Immunohistochemistry (IHC) was performed to verify the protein expression level of hub genes from tissues of COAD patients. Results: In the present study, we screened 323 common differentially expressed genes (DEGs) from four GSE datasets. Furthermore, four hub genes were selected for survival correlation analysis and expression level verification, three of which were shown to be statistically significant. Conclusion: Our study suggests that Serpin Family E Member 1 (SERPINE1), secreted phosphoprotein 1 (SPP1) and tissue inhibitor of metalloproteinase 1 (TIMP1) may be biomarkers closely related to the prognosis of CRC patients.
Long non-coding RNA RP11-284F21.9 functions as a ceRNA regulating PPWD1 by competitively binding to miR-769-3p in cervical carcinoma
Authors: Han Hong-Fang , Chen Qian , Zhao Wen-Wei 
Published: September 2020

Abstract
Cervical carcinoma is the most common gynecological cancer in women worldwide. Emerging evidence has shown that long non-coding RNAs (lncRNAs) participate in multiple biological processes of cervical carcinoma tumorigenesis. We aimed to investigate the function of a novel lncRNA RP11-284F21.9 in cervical carcinoma. We found that RP11-284F21.9 was down-regulated in cervical carcinoma tissues and cell lines. Overexpression of RP11-284F21.9 inhibits proliferation, invasion and migration of cervical carcinoma cells in vitro. Further, we identified that RP11-284F21.9 directly interacted with miR-769-3p and functioned as the miR-769-3p sponge. Mechanistically, we showed that miR-769-3p regulated peptidylprolyl isomerase domain and WD repeat-containing protein1 (PPWD1) expression by targeting PPWD1 3′-UTR. Furthermore, xenograft tumor model revealed that overexpression of RP11-284F21.9 inhibited tumor growth of cervical carcinoma in vivo. Taken together, our results demonstrate that RP11-284F21.9 functions as tumor suppressor and regulates PPWD1 expression through competitively binding to miR-769-3p in cervical carcinoma, suggesting that RP11-284F21.9/miR-769-3p/PPWD1 axis could serve as a promising prognostic biomarker and therapeutic target for cervical carcinoma.
CAD/CAM-gestützte Planung und Übertragungsmöglichkeiten von Brackets und Gaumenimplantaten
Authors: Jungbauer Rebecca , Eigenwillig Philipp , Becker Kathrin , Proff Peter 
Published: September 2020

ZusammenfassungIn der Kieferorthopädie kommen digitale Technologien zunehmend zum Einsatz. Während zunächst einzelne Arbeitsschritte, wie die Patientenverwaltung oder kieferorthopädische Diagnostik digital durchgeführt wurden, gibt es inzwischen einen Trend hin zu einem vollständig digitalisierten Workflow. Während digitale Technologien häufig die Stuhlzeit verkürzen, kann die digitale Vorbereitungszeit am Computer länger sein. Durch moderne Softwarelösungen lassen sich allerdings auch diese Arbeitsschritte effizient gestalten: Mithilfe entsprechender Software lässt sich bspw. die gewünschte Position der Brackets inklusive einer Übertragungsschablone im Rahmen der Multibracket-Behandlung vorab virtuell planen. Die Schablone kann im Anschluss mittels additiver Fertigungsverfahren (3D-Druck) in einem Labor oder in der Zahnarztpraxis hergestellt werden. Auch für eine skelettale Verankerung kann ähnlich zur zahnärztlichen Implantologie die Insertionsposition digital geplant und über Insertionsschablonen in den Patientenmund übertagen werden. Durch eine Überlagerung von DVT- oder FRS-Daten mit einem digitalen Modell kann die Position hinsichtlich des individuellen Knochenangebots optimiert werden.Das Ziel dieses Artikels ist es, einen Überblick über die Möglichkeiten der Bracket- und Mini-Implantat-Planung sowie Möglichkeiten zur Übertragung der virtuellen Planung in den Mund des Patienten klinisch vorzustellen und diese im Zusammenhang mit aktueller Literatur zu diskutieren.
Retention und digitale Entwicklung
Authors: Brämswig Simon Lukas , Pollak Tamara , Knaup Isabel , Wolf Michael 
Published: September 2020

ZusammenfassungDie kieferorthopädische Therapie gliedert sich in einen aktiv und
einen passiv begleiteten Abschnitt. Hierdurch könnte man annehmen,
dass letztere Phase seitens des Behandlers kaum zu beeinflussen ist.Das Gegenteil ist jedoch der Fall, denn schon in der Behandlungsplanung und
auch in der Durchführung können Maßnahmen getroffen
werden, um die sich anschließende Retentionsphase positiv zu
gestalten. So gilt es z. B. bestimmte Risikofaktoren
prätherapeutisch zu erkennen, um infolgedessen
stabilitätsfördernde Schritte einzuleiten.Ohne die erfolgreiche Retention eines kieferorthopädischen
Behandlungsergebnisses werden alle zuvor getroffenen aktiven
Maßnahmen zunichte gemacht. Aus diesem Grund stellt die Retention
einen wichtigen Baustein in der umfänglichen Versorgung der
Patienten dar.Dank neuer digitaler Technologien werden dem Kieferorthopäden
innovative Werkzeuge bereitgestellt, die zur Verbesserung einer
individualisierten Therapie beitragen können.
Schwangerschaftsabbrüche – Entscheidungsprozesse und Erfahrungen mit psychosozialer und medizinischer Versorgung aus Sicht junger Frauen
Authors: Böhm Maika 
Published: September 2020

ZusammenfassungEinleitung Schwangerschaftsabbrüche sichern reproduktive Selbstbestimmung und sind als Menschenrecht anerkannt. Gleichzeitig werden sie oft gesellschaftlich missbilligt, sind in Deutschland nach wie vor strafrechtlich verankert und erfordern eine Pflichtberatung.Forschungsziele Die vorliegende Studie verfolgt das Ziel zu rekonstruieren, warum und wie junge Frauen sich unter diesen Bedingungen für einen Schwangerschaftsabbruch entscheiden, wie sie dabei die Pflichtberatung und die medizinische Versorgung einschätzen und den Abbruch im Rückblick bewerten.Methoden Interviewdaten von n = 10 Studentinnen, die während ihrer (hoch-)schulischen Ausbildung einen Abbruch vornehmen ließen, wurden qualitativ erhoben und inhaltsanalytisch ausgewertet.Ergebnisse Die Daten zeigen, dass die Befragten klare und oft ähnliche Gründe für den Abbruch hatten und die Pflichtberatung bei ihrer Entscheidungsfindung kaum eine Rolle spielte. Im Rückblick beurteilten die Frauen den Abbruch als richtige Entscheidung.Schlussfolgerung Sinn und Nutzen der Pflichtberatung nach § 218a StGB gilt es ebenso zu überdenken wie das gesamte Unterstützungssystem, das bei ungewollten Schwangerschaften bereitsteht.
100 Jahre – Von Magnus Hirschfeld zur S3-Leitlinie und darüber hinaus: Körperorientierte Behandlungsverfahren als eine Option der Zukunft?
Authors: Güldenring Annette , Stern K. 
Published: September 2020

ZusammenfassungIn diesem Beitrag werden zentrale Inhalte der 2018 veröffentlichten S3-Leitlinie „Geschlechtsinkongruenz, Geschlechtsdysphorie und Trans-Gesundheit“, die sich dem Wissen vonMagnus Hirschfeld vor 100 Jahren wieder annähert, vorgestellt und diskutiert. Der zweite Teil widmet sich körper- und emotionsfokussierten Verfahren in der Versorgung von geschlechtlich nonkonformen Menschen, die bislang nur randständig im therapeutisch-pädagogischen und beraterischen Bereich angewandt werden. Es wird dafür plädiert, körper- und emotionsfokussierte Verfahren in die Regelversorgung zu integrieren; insbesondere – wie in den AWMF-Kriterien vorgeschrieben – mit Blick auf die bevorstehende Überarbeitung der S3-Leitlinie nach fünf Jahren in 2023. Dieser Zeitpunkt gibt auch die Chance, die in der aktuellen Leitlinie verwendete Sprache weiter zu ent-gendern, um mit einer geschlechtsinklusiven Nomenklatur nicht-binärem Geschlechtererleben gerecht zu werden.
Vom Symptom zum Syndrom
Authors: Holzapfel Klaus 
Published: September 2020

ZusammenfassungDie Entstehung der klinischen Homöopathie wird auf den Paradigmenwechsel der Medizin, der durch Virchows Zellularpathologie in der Mitte des 19. Jahrhunderts eintrat, zurückgeführt. Die neuen Veränderungen in der Homöopathie werden anhand von Beispielen aus der Literatur aufgezeigt.
Das Symptom
Authors: Klinkenberg Carl Rudolf 
Published: September 2020

ZusammenfassungAnhand der Geschichte der Migränebehandlung wird gezeigt, wie sich der homöopathische Symptombegriff fundamental vom traditionellen Symptombegriff unterscheidet. Mit dem Symptombegriff durchbricht Hahnemann das jahrtausendealte Paradigma der Krankheit als Erscheinung. Nur die sinnlich wahrnehmbaren Symptome werden in Ähnlichkeitsbeziehung mit der Arznei gesetzt. Es wird gezeigt, dass es Symptome gibt, die in einer konditionalen Beziehung zueinander stehen: die Causa-Symptome. Diese haben eine erstrangige Bedeutung bei der Mittelwahl. Gleichzeitig sind sie hypothetisch, dennoch Teil genuiner Homöopathie.
Verbena officinalis (Common Vervain) – A Review on the Investigations of This Medicinally Important Plant Species
Authors: Kubica Paweł , Szopa Agnieszka , Dominiak Jakub , Luczkiewicz Maria , Ekiert Halina 
Published: September 2020

AbstractVerbena officinalis (common vervain) is a medicinal plant species widely distributed in the world and commonly used in folk medicine of different countries, including traditional Chinese medicine. Monographs on “Verbenae herba” have been included in the European Pharmacopoeia since 2008, and in the Chinese Pharmacopoeia since 1995. This work presents botanical characteristics of this species. It reviews the current knowledge of its chemical composition, which is a rich source mostly of iridoids, phenylpropanoid glycosides, phenolic acids, flavonoids, terpenoids, and essential oil. A large part of this article summarizes traditional medicinal uses and professional pharmacological in vitro and in vivo studies that prove new important applications, e.g., antioxidant, antimicrobial, anti-inflammatory, neuroprotective anticancer, analgesic, or anticonvulsant of verbena herb extracts and individual metabolites. Moreover, emphasis is put on the use of V. officinalis in the food and cosmetics industries, especially due to its antioxidant, antibacterial, and anti-inflammatory properties, and the presence of essential oil with an attractive fragrance composition. This paper also presents the state of biotechnological studies of this species.
In vitro and In Vivo Immunomodulatory Activity of Physalis angulata Concentrated Ethanolic Extract
Authors: Daltro Sérgio Ricardo Teixeira , Santos Ivanilson Pimenta , Barros Paula Ladeia , Moreira Diogo Rodrigo Magalhães , Tomassini Therezinha Coelho Barbosa , Ribeiro Ivone Maria , Ribeiro dos Santos Ricardo , Meira Cássio Santana , Soares Milena Botelho Pereira 
Published: September 2020

AbstractThe need for new immunomodulatory drugs is due to the side effects associated with the prolonged use of the currently used immunomodulatory drugs. In this context, the present work aimed to investigate the immunomodulatory effect of an ethanolic concentrated extract from Physalis angulata. The cytotoxicity of samples was determined using peritoneal macrophages though the Alamar Blue assay. The immunomodulatory activity of the ethanolic extract from P. angulata on activated macrophages was determined by measurement of nitrite and cytokine production. The immunosuppressive effects of the ethanolic extract from P. angulata was evaluated on lymphocyte proliferation and cytokine production. The effects of the extract on cell cycle progression and cell death on lymphocytes were evaluated by flow cytometry. Lastly, the ethanolic extract from P. angulata was tested in vivo in toxicological tests and in models of peritonitis and delayed-type
hypersensitivity response. The ethanolic extract from P. angulata decreased nitrite, interleukin-6, interleukin-12, and TNF-α production by activated macrophages without affecting the cell viability. In addition, the ethanolic extract from P. angulata inhibited lymphoproliferation and the secretion of interleukin-2, interleukin-6, and IFN-γ, and increased interleukin-4 secretion by activated splenocytes. Flow cytometry analysis in lymphocyte cultures showed that treatment with the ethanolic extract from P. angulata induces cell cycle arrest in the G1 phase followed by cell death by apoptosis. Moreover, mice treated with the extract from P. angulata at 100 or 200 mg/kg did not show signs of toxicity or alterations in serum components. Finally, the ethanolic extract from P. angulata significantly reduced neutrophil migration and reduced paw edema in bovine serum albumin-induced the delayed-type hypersensitivity response
model. Our results demonstrate the potential of the ethanolic extract of P. angulata as an alternative for the treatment of immune-inflammatory diseases.
Orthopädie – Teilimplantat im Knie ist kostengünstiger als die totale Variante
Authors: Di Lellis Maddalena Angela 
Published: September 2020

Beard DJ. et al. The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomized controlled trial. Lancet 2019; 394: 746–756
Als Operationsoptionen bei schwerer Knieosteoarthritis stehen entweder ein totaler oder ein partieller Knieersatz zur Wahl. Spezialisten sind sich uneins, welche der beiden operativen Methoden bessere Endresultate bringt. Beard et al. untersuchten die klinische und wirtschaftliche Effektivität beider Methoden und evaluierten auftretende Komplikationen, die Patientenzufriedenheit und die Kostenauswirkungen für Patienten und das Gesundheitswesen.
Medial Epicanthoplasty: What Works and What Does Not
Authors: Baek Ji Sun , Choi Young Joo , Jang Jae Woo 
Published: September 2020

AbstractBlepharoplasty is the most frequently performed cosmetic surgical procedure in Asia. The epicanthal fold, which is common in Asians, is characterized by a curved skin fold that partially hides the caruncle and lacrimal lake. The epicanthal fold may cause weakening of the esthetic appearance after blepharoplasty. It makes the palpebral fissure height narrower and the length shorter horizontally. Blepharoplasty with epicanthoplasty can enhance the esthetic appearance, but no gold standard surgical technique has been established for epicanthoplasty. Surgeons can choose the surgical technique according to their preference and the patient's characteristics. A carefully designed and fine surgical technique, especially with the use of loupes and tension-free skin closure with the thinnest needle, is required to avoid scarring.
The Psychological Aspects of COVID-19: A Review
Authors: Sharma Bindu , Misra Pankhuri 
Published: September 2020

Abstract
Background The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It has affected 213 countries and territories around the world and 2 international conveyances, thus producing a significant impact on the physical and mental health, behaviour and economy. In this era of crisis, lot of guidelines and measures to combat the disease are present, but the area of adverse mental health consequences is still neglected. This review attempts to highlight the psychological problems associated with this disease.
Objective This article aims to retrieve from the existing literature and state the mental effects of COVID-19.
Methods A review was developed based on the articles from PubMed, Google Scholar, ScienceDirect, ResearchGate, Centers for Disease Control and Prevention, Elsevier, JAMA Network, The Lancet, New England Journal of Medicine, Cell, Wiley, Nature, Science and special databases for COVID like the Stephen B. Thacker CDC Library, World Health Organization's COVID-19 research article database, COVID-19 Open Research Dataset, LitCovid. The search terms included combination of ‘coronavirus’, ‘COVID-19’, ‘psychological’, ‘quarantine’, ‘children’. All the studies mentioning about the mental consequences and interventions for psychological repercussions associated with COVID-19 are eligible for inclusion. In addition, the research papers in English language have been included.
Conclusion There is a need for research among vulnerable population to study the long-term effects of psychological impact of COVID-19.
Telemedicine and Its Scope in COVID-19: Commentary
Authors: Pareek Kanupriya 
Published: September 2020

AbstractTelemedicine is a new concept that is developing with a lightning speed in developed countries. The practitioners of medicine are also using this as it has been legalised in many countries.In the coronavirus disease 2019 (COVID-19) times, when the buzzword is physical distancing, telemedicine assumes more importance. People are using this because of its easy availability, which cuts down their waiting time in the hospitals, it is easily accessible and is cost-effective. This is not only used by the modern science but also by the alternative systems of medicine like Ayurveda and Homoeopathy, as well as by the nutritionists, physiotherapists, yoga experts and so many others who are following these audio-visual and telecommunication techniques. It has worked well to reach out to the patients and resolve their queries. It is easy to reach to so many persons via a single platform and guide them. We are here to share some of our views on telemedicine and on the approach adopted by the people across the world, and discuss how it will be implemented by the future generation for the benefits of their lives and the society.
A behavioral analysis of whistleblowing at Japanese firms
Authors: Asaoka Daisuke 
Published: September 2020

AbstractThis paper analyzes the background to whistleblowing—one of the key means by which a spate of corporate misdeeds have been revealed at established Japanese firms—by applying a framework of psychology and organizational behavior to people’s decisions and judgments. The paper first analyzes the organizational aspects of whistleblowing, such as fear of retaliation within firms, and the psychological aspects, such as conflicts of interest that unconsciously favor sponsors. Despite such internal restraints, observed phenomena of whistleblowing paint a more nuanced picture of human psychology. Along with moral concerns, people have the desire to exhibit an appreciation of social trust and fairness, even when their actions are inconsistent with an economic calculus. Traditional Japanese firms are characterized by a collectivist culture featuring a meticulously crafted, closely knit internal order and lifetime employment. Information technology, however, has led to a more liquid flow of information on corporate misconduct, making it hard to conceal misdeeds that blur organizational boundaries and relativizing internal norms. These changes tip the psychological balance of people within firms and prompt firms to adapt. Changes in the corporate governance code, and a law requiring firms to introduce internal control systems, give whistleblowers the organizational protection which is key to according them psychological safety and encouraging constructive dissent. Advances in research from the behavioral perspective promise to deepen our understanding of Japanese corporate phenomena and behaviors.
Diverse sources and an internal foundation for voiced onsets in Northern Mǐn
Authors: Smith Jonathan 
Published: September 2020

AbstractThe voiced onsets and associated tonal reflexes of Northern Mǐn (NM), motivation for Norman’s (1973;1974) proto-Mǐn “softened” stops and affricates, remain a subject of controversy. Following a brief introduction (§ 1), I begin by reviewing the various apparent sources of voiced onsets in NM, including old complex onsets, non-Sinitic substrate, voicing alternations, and late koine material (§ 2). I then take upAkitani’s (2008)colloquial glossary of Shíbēi石陂andNorman’s (1969)of Jiànyáng建陽, outlining on this basis an adjusted account of the subgroup’s development: pre-PNM preserved early Sinitic voiced onsets in Tone A2, with a conditioned split isolating voiced stops in so-calledYángpíng yǐ陽平乙, here “A2+” (§ 3). It was this conservative feature which allowed items in§ 2to take on voiced onsets across tonal categories, at times leading to further splits. A conclusion considers Mǐn more generally, proposing that the voicing alternants of Huang Chin-wen (2001a) may be NM reflections of group-wide tone sandhi processes (§ 4).
Kokborok and the simple-complex reflexive distinction
Authors: Roy Gargi , Subbārāo Kārumūri V , Kumar Rajesh , Everaert Martin 
Published: September 2020

AbstractThis paper presents an in-depth investigation of the binding strategies in Kokborok and we will look more specifically how this sheds light on the theories of reflexivization. Kokborok, a Tibeto-Burman language spoken in Tripura, a state in the North-East of India, has two reflexives:sak sak‘self self’ andsak baithaŋ‘self self’. The formsak sak‘self self’ conforms to Principle A of classic Binding Theory, blocking long-distance binding, but this does not hold true forsak baithaŋallowing non-local binding. It is a well-established fact that some reflexives allow non-local binding, but it is generally assumed that this phenomenon is limited to a certain type of reflexive, morpho-syntactically ‘simple reflexives.’ The so-called ‘complex reflexives’ generally bar non-local binding, and the Kokborok reflexivesak baithaŋseems an exception to that. This paper explores the uniqueness involved in the nature of anaphoric binding in Kokborok.
Scalaron tunneling and the fate of antisymmetric tensor fields in F(R) gravity
Authors: Paul Tanmoy , SenGupta Soumitra 
Published: September 2020

Abstract
The work provides a possible explanation of a well motivated question—why the present Universe is practically free from any noticeable footmarks of higher rank antisymmetric tensor fields, despite having the signatures of scalar, vector, fermion as well as symmetric rank 2 tensor field in the form of gravity? The explanation proposed here originates from the higher curvature degrees of freedom present in a F(R) gravity model. In such a model, we show that the scalar degree of freedom (also known as scalaron) associated with the higher curvature term may undergo a quantum tunneling which in turn suppresses the couplings of antisymmetric massless tensor fields with various standard model fields.
Phase matching and quasi-phase matching of high-order harmonic generation—a tutorial
Authors: Hareli Liran , Shoulga Georgiy , Bahabad Alon 
Published: September 2020

Abstract
In this tutorial we discuss the macroscopic aspects of the extreme nonlinear frequency conversion process of high-order harmonic generation. For most, this entails describing the phase mismatch of the process and the means to mitigate it by tuning global parameters or by modulations perturbing the process. Additionally, we consider applications of phase matching in general for probing and for controlling different parameters of the emitted radiation.