bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutting through the noise: reducing bias in motor adaptation analysis
Authors: Blustein Daniel H. , Shehata Ahmed W. , Kuylenstierna Erin S. , Englehart Kevin B. , Sensinger Jonathon W. 
Published: November 2020

AbstractDuring goal-directed movements, the magnitude of error correction by a person on a subsequent movement provides important insight into a person’s motor learning dynamics. Observed differences in trial-by-trial adaptation rates might indicate different relative weighting placed on the various sources of information that inform a movement, e.g. sensory feedback, control predictions, or internal model expectations. Measuring this trial-by-trial adaptation rate is not straightforward, however, since externally observed data are masked by noise from several sources and influenced by inaccessible internal processes. Adaptation to perturbation has been used to measure error adaptation as the introduced external disturbance is sufficiently large to overshadow other noise sources. However, perturbation analysis is difficult to implement in real-world scenarios, requires a large number of movement trials to accommodate infrequent perturbations, and the paradigm itself might affect the movement dynamics being observed. Here we focus on error adaptation during unperturbed and naturalistic movements. With increasing motor noise, the conventional estimation of trial-by-trial adaptation increases, a counterintuitive finding that is the consequence of systematic bias in the estimate due to noise masking the learner’s intention. We present an analytic solution relying on stochastic signal processing to reduce this effect of noise, producing an estimate of motor adaptation with reduced bias. The result is an improved estimate of trial-by-trial adaptation in a human learner compared to conventional methods. We demonstrate the effectiveness of the new method in analyzing simulated and empirical movement data under different noise conditions. The analytic approach is applicable across different types of movements in varied contexts and should replace the regression analysis method in future motor analysis studies.Author SummaryWhen a person makes a movement, a motor error is typically observed that then drives motor planning corrections on subsequent movements. This error correction provides insight into how the nervous system is operating, particularly in regard to how much confidence a person places in different sources of information such as sensory feedback or motor command reproducibility. Traditional analysis of movement has required carefully controlled laboratory conditions, limiting the usefulness of motor analysis in clinical and everyday environments. Here we present a new computational method that can be accurately applied to typical movements. Counterintuitive findings of the established approach are corrected by the proposed method. This method will provide a common framework for researchers to analyze movements while extending dynamic motor adaptation analysis capabilities to clinical and non-laboratory settings.
mTORC1 and JUN are activated after deletion of Prohibitin 1 in Schwann cells and may link mitochondrial dysfunction to demyelination
Authors: Della-Flora Nunes Gustavo , Wilson Emma R. , Hurley Edward , He Bin , O’Malley Bert W. , Poitelon Yannick , Wrabetz Lawrence , Feltri M. Laura 
Published: November 2020

AbstractSchwann cell (SC) mitochondria are quickly emerging as an important regulator of myelin maintenance in the peripheral nervous system (PNS). However, the mechanisms underlying demyelination in the context of mitochondrial dysfunction in the PNS are incompletely understood. We recently showed that conditional ablation of the mitochondrial protein Prohibitin 1 (Phb1) in SCs causes a severe and fast progressing demyelinating peripheral neuropathy, but the mechanism that causes failure of myelin maintenance remained unknown. Here, we report that mTORC1 and JUN are continuously activated in the absence ofPhb1, likely due to mitochondrial damage. Moreover, we demonstrate that these pathways are involved in the demyelination process, and that inhibition of mTORC1 using rapamycin partially rescues the demyelinating pathology. Therefore, we propose that mTORC1 and JUN may play a critical role as executioners of demyelination in the context of perturbations to SC mitochondria.
Silencing SmD1 in Solanaceae alters susceptibility to root-knot nematodes
Authors: Mejias Joffrey , Chen Yongpan , Truong Nhat-My , Mulet Karine , Jaubert-Possamai Stéphanie , Abad Pierre , Favery Bruno , Quentin Michaël 
Published: November 2020

SummaryRoot-knot nematodes (RKNs) are among the most damaging pests of agricultural crops. Indeed, Meloidogyne is an extremely polyphagous genus of nematodes that can infect thousands of plant species. A few genes for resistance (R-genes) to RKNs suitable for use in crop breeding have been identified, and new virulent strains and species of nematode emerge rendering these R-genes ineffective. Effective parasitism is dependent on the secretion, by the RKN, of effectors targeting plant functions, which mediate the reprogramming of root cells into specialised feeding cells. These cells, the giant cells, are essential for RKN development and reproduction. The EFFECTOR 18 protein (EFF18) from M. incognita interacts with the spliceosomal protein SmD1 in Arabidopsis, disrupting its function in alternative splicing regulation and modulating the giant cell transcriptome. We show here that EFF18 is a conserved RKN-specific effector. We also show here that EFF18 effectors also target SmD1 in Nicotiana benthamiana and Solanum lycopersicum. The alteration of SmD1 expression by virus-induced gene silencing (VIGS) in Solanaceae affects giant cell formation and nematode development. Thus, SmD1 is a susceptibility gene and a promising target for the development of broad resistance, especially in Solanaceae, for the control of Meloidogyne spp.
Heightened β-adrenergic receptor function in the TgF344-AD rat model drives synaptic potentiation and supports learning and memory
Authors: Goodman Anthoni M. , Langner Bethany M. , Jackson Nateka , Alex Capri , McMahon Lori L. 
Published: November 2020

AbstractThe central noradrenergic (NA) system is critical for maintenance of attention, behavioral flexibility, spatial navigation, and learning and memory, those cognitive functions lost first in early Alzheimer’s disease (AD). In fact, the locus coeruleus (LC), the sole source of norepinephrine (NE) for >90% of the brain, is the first site of pathological tau accumulation in human AD with axon loss throughout forebrain, including hippocampus. The dentate gyrus (DG) is heavily innervated by LC-NA axons, where released norepinephrine (NE) acts on β-adrenergic receptors (ARs) at excitatory synapses from entorhinal cortex (EC) to facilitate long-term synaptic plasticity and memory formation. These synapses dysfunction in early AD prior to cognitive impairment. In the TgF344-AD rat model, degeneration of LC-NA axons in hippocampus recapitulates human AD, providing a preclinical model to investigate synaptic and behavioral consequences. Using immunohistochemistry, Western blot analysis, and brain slice electrophysiology in 6-9 month old wild type and TgF344-AD rats, we discovered that loss of LC-NA axons co-insides with heightened β-AR function at medial perforant path-dentate granule cell synapses (MPP-DCG) that is responsible for the increase in LTP magnitude at these synapses. Furthermore, novel object recognition is facilitated in TgF344-AD rats that requires β-ARs, and pharmacological blockade of β-ARs unmasks a deficit in extinction learning only in TgF344-AD rats, indicating a greater reliance on β-ARs in both behaviors. Thus, a compensatory increase in β-AR function during prodromal AD in TgF344-AD rats heightens synaptic plasticity and preserves some forms of learning and memory.Significance StatementThe locus coeruleus (LC), a brain region located in the brainstem which is responsible for attention and arousal, is damaged first by Alzheimer’s disease pathology. The LC sends axons to hippocampus where released norepinephrine (NE) modulates synaptic function required for learning and memory. How degeneration of LC axons and loss of NE in hippocampus in early AD impacts synaptic function and learning and memory is not well understood despite the importance of LC in cognitive function. We used a transgenic AD rat model with LC axon degeneration mimicking human AD and found that heightened function of β adrenergic receptors in the dentate gyrus increased synaptic plasticity and preserved learning and memory in early stages of the disease.
Automated and customizable quantitative image analysis of wholeC. elegansgermlines
Authors: Toraason Erik , Adler Victoria L. , Kurhanewicz Nicole A. , DiNardo Acadia , Saunders Adam M. , Cahoon Cori K. , Libuda Diana E. 
Published: November 2020

AbstractArranged in a spatial-temporal gradient for germ cell development, the adult germline ofCaenorhabditis elegansis an excellent system for understanding the generation, differentiation, function, and maintenance of germ cells. Imaging wholeC. elegansgermlines along the distal-proximal axis enables powerful cytological analyses of germ cell nuclei as they progress from the pre-meiotic tip through all the stages of meiotic prophase I. To enable high-throughput image analysis of wholeC. elegansgonads, we developed a custom algorithm and pipelines to function with image processing software that enables: 1) quantification of cytological features at single nucleus resolution from immunofluorescence images; and, 2) assessment of these individual nuclei based on their position within the germline. We demonstrate the capability of our quantitative image analysis approach by analyzing multiple cytological features of meiotic nuclei in wholeC. elegansgermlines. First, we quantify double strand DNA breaks (DSBs) per nucleus by analyzing DNA-associated foci of the recombinase RAD-51 at the single-nucleus resolution in the context of whole germline progression. Second, we quantify the DSBs that are licensed for crossover repair by analyzing foci of MSH-5 and COSA-1 when they associate with the synaptonemal complex during meiotic prophase progression. Finally, we quantify P-granule composition across the whole germline by analyzing the colocalization of PGL-1 and ZNFX-1 foci. Our image analysis pipeline is an adaptable and useful method for researchers spanning multiple fields utilizing theC. elegansgermline as a model system.
Design simulations of a horizontally deflecting high-heat-load monochromator
Authors: Brumund Philipp , Reyes-Herrera Juan , Detlefs Carsten , Morawe Christian , Sanchez del Rio Manuel , Chumakov Aleksandr I. 
Published: November 2020

The performance of a liquid-nitrogen-cooled high-heat-load monochromator with a horizontal scattering plane has been analysed, aiming to preserve the high quality of the X-ray beam in the vertical plane for downstream optics. Using finite-element analysis, height profiles of the crystal surface for various heat loads and the corresponding slope errors in the meridional and sagittal planes were calculated. Then the angular distortions of the reflected beam in both meridional and sagittal planes were calculated analytically and also modelled by ray tracing, revealing a good agreement of the two approaches. The results show that with increasing heat load in the crystal the slope errors of the crystal surface reach their smallest values first in the sagittal and then in the meridional plane. For the considered case of interest at a photon energy of 14.412 keV and the Si(111) reflection with a Bragg angle of 7.88°, the angular distortions of the reflected beam in the sagittal plane are an order of magnitude smaller than in the meridional one. Furthermore, they are smaller than the typical angular size of the beam source at the monochromator position. For a high-heat-load monochromator operating in the horizontal scattering plane, the sagittal angular distortions of the reflected beam appear in the vertical plane. Thus, such an instrument perfectly preserves the high quality of the X-ray beam in the vertical plane for downstream optics. Compared with vertical scattering, the throughput of the monochromatic beam with the horizontal scattering plane is reduced by only 3.3% for the new EBS source, instead of 34.3% for the old ESRF-1 machine. This identifies the horizontal-scattering high-heat-load monochromator as a device essentially free of the heat-load effects in the vertical plane and without significant loss in terms of throughput.
Choosing to be homeless? Persistent rough sleeping and the perverse incentives of social policy in England
Authors: Bowpitt Graham 
Published: November 2020

Purpose
With the temporary housing of rough sleepers in response to the Covid-19 emergency, some commentators have been tempted to believe that the rising population of rough sleepers in the UK has finally been reversed. This paper aims to examine the choices made by persistent rough sleepers and how far they are influenced by the perverse incentives of social policies, in order to challenge the view that they sleep rough out of choice.

Design/methodology/approach
Evidence for this paper is derived from two teams of frontline service providers with routine familiarity with the rough sleeping population: a street outreach team and a team of support workers working with adults with multiple and complex needs. Primary data from focus groups were combined with the secondary analysis of both numerical and narrative accounts routinely recorded by both teams.

Findings
The exercise of agency by persistent rough sleepers is constrained by a mixed baggage of complex needs, past negative risk assessments, limited resources and regulatory deterrents to generate choices to reject help that appear irrational. These need to be understood if recent policy initiatives to end rough sleeping are to be effective.

Originality/value
The paper draws on the experience and comprehensive records of practitioners with intimate knowledge of the rough sleeping population. It extends narrative accounts of causes by focusing on key choices to show how the perverse incentives of policy combine with personal factors to incline rough sleeping to persist.
Understanding the customer psychology of impulse buying during COVID-19 pandemic: implications for retailers
Authors: Naeem Muhammad 
Published: November 2020

PurposeDuring COVID-19 pandemic, the use of social media enhances information exchange at a global level; therefore, customers are more aware and make backup plans to take optimal decisions. This study explores the customer psychology of impulse buying during COVID-19 pandemic.Design/methodology/approachThe researcher, being a social constructionist, aims at understanding social patterns in impulsive buying strategies during COVID-19 pandemic. Forty UK consumers were participated using the telephonic interview method with the purpose to maintain social distancing practices.FindingsResults revealed that vulnerable group of people, fear of illness, fear of empty shelves, fear of price increase and social inclination to buy extra for staying at home, increased panic impulsive buying behaviour among customers. Many people socially interpreted the evidence of death rate and empty shelves, which led to more disinformation, rumours and sensationalism, which increased customers' impulsive buying behaviour. Finally, risk of going outside, COVID-19 outbreak among employees of local retail stores, and health professionals' recommendations to stay at home, led to impulsive buying behaviour.Originality/valueThis study has constructed a research framework of customer psychology of impulse buying based on the results of this study and fear and perceived risk theories. The study also explains how the fear of fear, risk perception and conformist tendency enhanced impulsive buying during COVID-19 pandemic. This study has discussed specific implications for retailers.
Collaboration between supply chain partners: when does it matter? Evidence from collaborative profiles
Authors: Kumar Gopal 
Published: November 2020

Purpose
Considering the limitations of supply chain collaboration (SCC) literature, the purpose of this paper is to develop SCC framework and analyze the SCC practice based on the framework. The framework incorporating internal and external knowledge sharing under a collaborative culture (CC) and problem-solving environment preceded by preparedness is required.

Design/methodology/approach
To achieve successful collaboration, this paper encompasses problem-solving and performance measurement, preparedness, culture, relationship strength (RS) and gives resource sharing and planning as internal and external focused perspectives. Exploratory methods are used to analyze the data from industries.

Findings
CC, RS and preparedness are crucial that reflect the health of collaboration. Three levels of collaboration practice – good, moderate and weak – are prominent where the extent of SCC practice seems weak. Collaborative activities that matter more are identified. Market-based knowledge sharing is important for good and moderate SCC, while weaker collaboration does not focus on it. Interestingly, this paper finds an increasing level of collaboration may not always result in increased performance. Firms from the pharmaceutical, automobile and electrical/electronic industry tended to practice higher collaboration as compared to other industries.

Originality/value
By integrating market-driven management, resource-based view, and contingency theory, the SCC framework gives a new perspective. Joint planning and resource sharing are categorized as internal and external focused functional areas. The paper identifies three profiles of collaboration and discusses the importance of SCC activities in achieving performance.
Quantification of financial consequences of buildings' ageing: analysis of panel building-level data from the Polish office space market
Authors: Kołodziejczyk Bolesław , Osiichuk Dmytro , Mielcarz Paweł 
Published: November 2020

PurposeRelying on a unique proprietary Polish office market space database, the paper attempts to quantify the impact of buildings' age on the financial performance of real estate assets.Design/methodology/approachPanel econometric modeling was utilized to disentangle the impact of buildings' functional obsolescence and technical deterioration on their long-term financial performance.FindingsIn line with casual empiricism, our findings show a negative associative link between properties' age and potential lease revenue. The concomitant stickiness of service charges presages a possible long-term deterioration of financial outcomes of real estate investments. While older buildings generally have higher occupancy rates, the absorption rates are found to be negatively affected by the properties' age. On the bright side, the elasticity of vacancy rate with respect to rental rates is found to decrease as buildings get older. Further, the rent differential is confirmed to be more pronounced in higher age properties hinting at an existing potential for price discrimination, which may at least partially compensate for stagnant rents.Originality/valueOur empirical results confirm the properties' age to be a statistically significant factor in shaping the long-term performance of real estate assets, which should be better accounted for in financial projections for real estate developments.
A framework for integrating strategic HR and knowledge management for innovation performance
Authors: Trivedi Karishma , Srivastava Kailash Bihari Lal 
Published: November 2020

PurposeOrganizations that resort to knowledge management (KM) for innovation need to align their organizational strategies for KM success. The purpose of this paper is to develop a conceptual framework depicting the alignment of strategic HR practices with organizational culture and strategy. This alignment posits to leverage KM processes for improving innovation performance in organizations.Design/methodology/approachDrawing from configurational–contingent HR perspective, this paper reviews the literature critically to identify the role and relationship among strategic HR practices, organizational culture and business strategy in contributing to KM process and innovation.FindingsComplementarity between strategic HR practices with business strategy and organizational culture can create a synergistic effect on the KM process for improved innovation performance.Research limitations/implicationsThis paper is theoretical. To validate the proposed conceptual framework, it needs empirical verification by future studies.Practical implicationsManagements should configure their HR practices with strategy and enable a knowledge-oriented culture to develop employee capabilities, creating intellectual assets for bringing more innovativeness in organizations.Originality/valueThe paper addresses the gap by relating strategic HR practices, strategy and culture in KM context with firm innovation in a comprehensive model. It is among the few studies to critically review strategic human resource practices-KM relationship from contingent–configurational HR perspective, relevant for HR managers in the current knowledge-based organizations.
Video-modelling as an effective solution for coaching carers of autistic adults
Authors: Cohen Gabriel , McGill Peter 
Published: November 2020

PurposeTeaching skills to autistic individuals can increase independence and quality of life. However, staff supporting such individuals often lack the skills needed to teach skills. This study evaluated the use of digital videos (DVDs) to coach three care staff in teaching tooth-brushing skills to three autistic adults with co-occurring intellectual disabilities.Design/methodology/approachPersonalized DVDs provided guidance on key elements of teaching new skills, including graded assistance, contingent reinforcement and environmental configuration. Participants watched their DVD six times over several days. Its impact on their teaching performances was evaluated using a multiple-baseline design. Social validity was investigated by distributing a questionnaire among the participants and family members of autistic adults.FindingsTeaching performances improved substantially following training. The coaching method was rated positively by participants and family members.Originality/valueVideo-modelling technology can be used effectively to provide an efficient, individualized and acceptable method of coaching for care staff.
COVID-19 lockdown: the unspoken toll on the 65+ community in Turkey
Authors: Ates Ozgur 
Published: November 2020

Purpose
On March 21, 2020, the Turkish Government imposed a curfew for citizens 65 years old and over and ordered them to stay at home as a measure to protect them against the COVID-19 outbreak. The curfew ended on June 10, 2020, having lasted 82 days. The purpose of this paper is to examine the significant emotional burden on the elderly, as they felt excluded and battled with despair during the lockdown.

Design/methodology/approach
This reflective paper shares the COVID-19 lockdown experiences of the author with a group of elderly residents of a small community in Ankara, Turkey. Through semi-structured interviews and analysis, three overarching themes of the residents’ experience were identified: vulnerability, social isolation/loneliness and ageism.

Findings
The elderly in the community are individuals who get their social interaction outside the home. As a result of the nearly three months of social isolation, they have experienced social disconnection and health problems,

Originality/value
To the best of the author’s knowledge, this is the first attempt to give voice to the silenced group of elderly and share their thoughts and feelings during this difficult COVID-19 lockdown in Turkey.