bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes of soil-rhizosphere microbiota after organic amendment application in a Hordeum vulgare L. short-term greenhouse experiment
Authors: Obermeier Michael M. , Minarsch Eva-Maria L. , Durai Raj Abilash C. , Rineau Francois , Schröder Peter 
Published: August 2020

Abstract
Aims
In order to counteract the enduring decreases in the quality of agricultural land, mechanistic studies for a more sustainable agricultural crop production were performed. They aimed to assess the effects of organic amendments in combination with mineral fertilizer on soil-rhizosphere microbiota and their influence on soil health and plant performance.

Methods
In a short-term greenhouse experiment, the effects of pelletized spent mushroom substrate, with different combinations of biochar and mineral fertilizer, on agricultural soil and performance of Hordeum vulgare L were scrutinized. To evaluate improved soil quality, different soil biological and chemical properties, microbial activity, bacterial diversity and plant performance were assessed.

Results
Plant performance increased across all fertilizer combinations. Bacterial β-diversity changed from the initial to the final sampling, pointing at a strong influence of plant development on the rhizosphere with increasing abundances of Acidobacteria and decreasing abundances of Actinobacteria, Chloroflexi, and Bacteroidetes. Microbial activity (FDA), potential enzyme activity and metabolic diversity of the microbial community (BIOLOG) were not affected by the amendments, whereas bacterial community structure changed on family level, indicating functional redundancy. Treatments containing biochar and the highest amount of mineral fertilizer (B_MF140) caused the strongest changes, which were most pronounced for the families Xanthobacteraceae, Mycobacteriaceae, and Haliangiaceae.

Conclusion
Applying organic amendments improved plant performance and maintained soil health, contributing to more sustainable crop production. Nevertheless, long-term field studies are recommended to verify the findings of this short-term experiment.
Beyond linear conciliation
Authors: Kuan Ko-Hung 
Published: August 2020

AbstractFormal epistemologists criticise the Conciliatory View of peer disagreement for being non-commutative with conditionalisation, path dependent and does not preserve the independence between propositions. Failing to commute with conditionalisation, one may switch the order between conciliating and conditionalising and obtain different outcomes. Failing to be path independent, the outcome of conciliation varies with the order of the acquisition of new testimonies. Failing to preserve the independence between propositions, one may suffer from a sure-loss and hence be deemed irrational. The three formal deficiencies urge people to abandon the Conciliatory View. This paper aims to show that one may save the Conciliatory View by conciliating with nonlinear functions. Research in the study of opinion pooling shows that the three deficiencies are not problems of the Conciliatory View, but problems of linear averaging. Hence, one can get rid of these formal deficiencies by making conciliation with nonlinear averaging functions. After showing how the three deficiencies can be avoided, I will explore the features of nonlinear averaging functions and argue that they have properties that correctly capture people’s intuition concerning disagreement. The conclusion, therefore, is to suggest epistemologists develop a more fine-grained taxonomy for cases of disagreement. With a deliberate categorisation of different kinds of disagreement, epistemologists can pick the proper averaging rule to apply in each specific case, and get rid of possible formal deficiencies.
Manufacturing and mechanical properties of composite orthotropic Kagome honeycomb using novel modular method
Authors: Niu Bin , Li Shijie , Yang Rui 
Published: August 2020

AbstractThis work deals with manufacturing and analysis of orthotropic composite Kagome honeycomb panels. A novel modular mold is proposed to manufacture carbon fiber reinforced composite Kagome honeycombs. The designed mold can be assembled freely to manufacture Kagome honeycombs with different configuration combinations and can realize easy demolding. Furthermore, two typical fiber placement methods are considered during the fabrication process, from which the more effective fiber placement method is determined. Finally, representative volume element method is used to perform homogenization analysis of the Kagome honeycomb panels and to obtain equivalent in-plane and bending stiffness. Finite element analysis using these equivalent properties is conducted and validated against the experimental results of the manufactured composite Kagome honeycomb panels under different loading cases.
Persistent Genital Arousal Disorder: a Biopsychosocial Framework
Authors: Jackowich Robyn A. , Pukall Caroline F. 
Published: August 2020

Abstract
Purpose of Review
Persistent genital arousal disorder (also referred to as genitopelvic dysesthesia or PGAD/GD) is a distressing and largely underrecognized condition characterized by persistent, unwanted genital arousal (sensations, sensitivity, vasocongestion) in the absence of subjective/cognitive arousal and sexual desire. The purpose of this review is to summarize recent findings on biological and psychosocial factors in PGAD/GD as they pertain to the assessment and treatment of this condition. These findings will be considered within a biopsychosocial framework, for the purposes of considering next steps for clinical and research efforts.

Recent Findings
A small number of studies have recently examined potential biological aetiologies for PGAD/GD: pharmacological agents, spinal pathology and peripheral nerve involvement. Recent studies have also found that PGAD/GD is associated with a significant negative impact on psychosocial wellbeing and daily functioning as compared to symptom-free individuals. In addition, these results highlight cognitive/affective responses to symptoms (e.g. catastrophizing of symptoms) that may influence outcomes. However, biological and psychological research are rarely integrated in these studies, despite the interrelationship between these factors.

Summary
Although PGAD/GD was first described in the scientific literature almost two decades ago, most research on PGAD/GD is presented in the form of case studies. Prospective treatment trials that integrate biopsychosocial factors are needed in order to provide effective and efficient care to this population. This research would be facilitated by the development of a patient-reported outcome measure, as well as greater education/awareness among healthcare providers and the public about this distressing condition.
Supercharged eGFP-TRAIL Decorated NETs to Ensnare and Kill Disseminated Tumor Cells
Authors: Cao Thong M. , King Michael R. 
Published: August 2020

Abstract
Background
NETosis is an innate immune response elicited by activated neutrophils to fight microbial infections. Activated neutrophils release DNA fibers decorated with anti-microbial proteins called neutrophil extracellular traps (NETs) into the extracellular space to trap and kill surrounding microbes.

Methods
Here, we show that tumor-derived IL-8 released by cancer cells also activates the release of NETs. Until now, there have been no existing technologies that leverage NETs as an anti-tumor drug delivery vehicle. In this study, we demonstrate the re-engineering of neutrophils to express an apoptosis-inducing chimeric protein, supercharged eGFP-TRAIL, on NETs that can ensnare and kill tumor cells while retaining their anti-microbial capabilities.

Results
We observed significant TRAIL-induced apoptosis in tumor cells captured by TRAIL-decorated NETs.

Conclusions
This work demonstrates NETs as a promising technology to deliver protein in response to local cytokine signals.
Not only laboratory to clinic: the translational work of William S. C. Copeman in rheumatology
Authors: Worboys Michael , Toon Elizabeth 
Published: August 2020

AbstractSince the arrival of Translational Medicine (TM), as both a term and movement in the late 1990s, it has been associated almost exclusively with attempts to accelerate the “translation” of research-laboratory findings to improve efficacy and outcomes in clinical practice (Krueger et al. in Hist Philos Life Sci 41:57, 2019). This framing privileges one source of change in medicine, that from bench-to-bedside. In this article we dig into the history of translation research to identify and discuss three other types of translational work in medicine that can also reshape ideas, practices, institutions, behaviours, or all of these, to produce transformations in clinical effectiveness. These are: (1) making accessible state-of-the-art knowledge and best practice across the medical profession; (2) remodelling and creating institutions to better develop and make available specialist knowledge and practice; and (3) improving public and patient understandings of disease prevention, symptoms and treatments. We do so by examining the work of William S. C. Copeman, a dominant figure in British rheumatology from the 1930 through the late 1960s. Throughout his long career, Copeman blended approaches to “translation” in order to produce transformative change in clinical medicine, making his work an exemplar of our expanded notion of TM.
Association Between Body Mass Index and Female Sexual Dysfunction: A Cross-sectional Study from the Data Registry on Experiences of Aging, Menopause, and Sexuality
Authors: Faubion Stephanie S. , Fairbanks Flavia , Kuhle Carol L. , Sood Richa , Kling Juliana M. , Vencill Jennifer A. , Mara Kristin C. , Kapoor Ekta 
Published: August 2020

Abstract

Background
Obesity and female sexual dysfunction (FSD) are prevalent conditions, and both are associated with significant adverse effects on health and well-being.

Aim
To investigate the association between body mass index and FSD, as well as potential moderators.

Methods
This cross-sectional study was performed by analyzing medical records of 6,688 women seeking consultation for menopause-related or sexual health–related concerns at women’s health clinics at Mayo Clinic Rochester, MN, and Scottsdale, AZ, between May 1, 2015, and September 15, 2019.

Outcomes
Female sexual function was assessed by the Female Sexual Function Index, and sexual distress was assessed by the Female Sexual Distress Scale-Revised.

Results
Being overweight or obese was associated with a lack of sexual activity. Among sexually active women, those who were overweight or obese had lower Female Sexual Function Index total scores and sexual function domain scores (indicating worse sexual function), including sexual arousal, lubrication, satisfaction, orgasm, and pain, and higher levels of sexual distress than those with normal weight. However, on multivariable analysis, these associations were found to be mediated by other factors, including age, level of education, reproductive stage, medication use, and mood disturbances, which are known to impact body weight and sexual function in women.

Clinical Implications
Overweight and obesity were associated with sexual inactivity and greater odds of having FSD, which should prompt proactive assessment of sexual function.

Strengths and Limitations
The strengths of this study include the large cohort size and assessment of sexual problems in addition to sexual distress, a key component of the definition of sexual dysfunction. This study also took into account multiple potential moderating factors. Limitations include the cross-sectional design, which precludes determination of causality as well as lack of diversity in the cohort, potentially limiting generalizability of results. In addition, sexual function was not assessed in women reporting no recent sexual activity, which may confound results.

Conclusion
Overweight/obesity and FSD are highly prevalent conditions, which appear to be indirectly associated. These results highlight the need to identify and address FSD in all overweight and obese women, with particular attention to potential contributing factors.
The phenomenology of auditory verbal hallucinations in emotionally unstable personality disorder and post-traumatic stress disorder
Authors: Wallis S. , Denno P. , Ives J. , Mallikarjun P. , Wood S. J. , Oyebode F. , Broome M. , Upthegrove R. 
Published: August 2020

Objective:To explore the phenomenology of auditory verbal hallucinations (AVHs) in a clinical sample of young people who have a ‘non-psychotic’ diagnosis.Methods:Ten participants aged 17–31 years with presentation of emotionally unstable personality disorder or post-traumatic stress disorder and frequent AVHs were recruited and participated in a qualitative study exploring their subjective experience of hearing voices. Photo-elicitation and ethnographic diaries were used to stimulate discussion in an otherwise unstructured walking interview.Results:‘Non-psychotic’ voices comprised auditory qualities such as volume and clarity. Participants commonly personified their voices, viewing them as distinct characters with which they could interact and form relationships. There appeared to be an intimate and unstable relationship between participant and voice, whereby voices changed according to the participants’ mood, insecurities, distress and circumstance. Equally, participants reacted to provocation by the voice, leading to changes in mood and circumstance through emotional and physical disturbances. In contrast to our previous qualitative work in psychosis, voice hearing was not experienced with a sense of imposition or control.Conclusions:This phenomenological research yielded in-depth and novel accounts of ‘non-psychotic’ voices which were intimately linked to emotional experience. In contrast to standard reports of voices in disorders such as schizophrenia, participants described a complex and bi-directional relationship with their voices. Many other features were in common with voice hearing in psychosis. Knowledge of the phenomenology of hallucinations in non-psychotic disorders has the potential to inform future more successful management strategies. This report gives preliminary evidence for future research.
Correction of Local Collection Efficiency Based on Roughness Element Concept for Glaze Ice Simulation
Authors: Yoon Taekeun , Yee Kwanjung 
Published: August 2020

ABSTRACTIn glaze ice conditions, beads on the surface usually grow to form roughness elements through coalescence, finally resulting in enhancement of local collection efficiency. However, the effects of roughness elements due to freezing of beads are not reflected on the local collection efficiency in CFD icing simulations. This is problematic for predicting the resultant ice shape, which may lead to inaccurate aerodynamic performance and load distribution. The aim of this study is to propose a macroscopic icing model which can reflect bead microscopic phenomena using the Eulerian approach. To this end, a correction was made for collection efficiency by introducing a novel parameter - the effective impinging angle- which is the angle to calculate the local collection efficiency depending on the physical state of surface. It is assumed that the parameter related to the contact angle represents the state of beads. The computational icing analysis of airfoil was performed using the proposed model both in the rime condition and glaze conditions. The results show that the icing characteristics in the feather region is captured with enhanced accuracy in both conditions.
Europeanisation on demand: the EU cybersecurity certification regime between market integration and core state powers (1997–2019)
Authors: Sivan-Sevilla Ido 
Published: August 2020

AbstractDespite promises by European Union (EU) policymakers to “fundamentally change” cybersecurity certification, they have recently created a regime that is strikingly similar to already existing certification arrangements. How can we explain this puzzle? Through a process-tracing analysis based on 41 documents and 18 interviews, this article traces the development of the EU cybersecurity certification regime over the past two decades. It deconstructs certification into standardisation, accreditation, certification, and evaluation; analyses how each regime component changed over time; and discusses to what extent causal mechanisms that are derived from classic theories of EU integration explain the limited nature of policy change. The observed dynamics uncover a “Europeanization on Demand” model that allows national authorities to completely control the extent of integration. This study challenges the dichotomous understanding portrayed by EU integration literature, of mutually exclusive dynamics of market or core state powers integration, highlighting intriguing political dynamics in EU cybersecurity policymaking.
A latent class analysis of health lifestyles and health outcomes among Chinese older adults
Authors: Zhang Li 
Published: August 2020

AbstractPrior analyses have repeatedly documented the association between individual health behaviours and health outcomes. Nonetheless, few studies have taken a health lifestyle theory approach to examine how health lifestyle behaviours have shaped Chinese older adults’ health status. Using the most recent 2011–2012 data released by the Chinese Longitudinal Healthy Longevity Survey (CLHLS), latent class analysis was applied to identify predominant health lifestyles among Chinese older adults aged 65–105. Four distinct classes representing health lifestyles emerged. Furthermore, the research found the way in which the four classes representing older adults’ health lifestyles can be predicted by the respondent's demographic and socio-economic characteristics. In addition, health lifestyles were found to be strongly associated with Chinese older adults’ health outcomes which were measured by self-rated health, functional independence, cognitive function and chronic diseases, even after controlling for demographic features as well as individual and parental socio-economic disadvantage. Findings supported the cumulative disadvantage theory in health. The research highlighted the importance of promoting health lifestyles to improve older adults’ health outcomes.
Pooling of coronavirus tests under unknown prevalence
Authors: Pikovski A. , Bentele K. 
Published: August 2020

Abstract
Diagnostic testing for the novel coronavirus is an important tool to fight the coronavirus disease (Covid-19) pandemic. However, testing capacities are limited. A modified testing protocol, whereby a number of probes are ‘pooled’ (i.e. grouped), is known to increase the capacity for testing. Here, we model pooled testing with a double-average model, which we think to be close to reality for Covid-19 testing. The optimal pool size and the effect of test errors are considered. The results show that the best pool size is three to five, under reasonable assumptions. Pool testing even reduces the number of false positives in the absence of dilution effects.
Sub-clinical myocardial ischaemia due to cardiac strangulation by an epicardial pacemaker lead
Authors: Muneuchi Jun , Doi Hirohito , Watanabe Mamie , Ochiai Yoshie 
Published: August 2020

AbstractWe present the case of a 10-year-old boy with congenital complete atrioventricular block who had cardiac strangulation by an epicardial pacemaker lead placed during infancy. Coronary angiography and Tc99m tetrofosmin myocardial perfusion scintigraphy suggested sub-clinical myocardial ischaemia.
Learning from health system reform trajectories in seven Canadian provinces
Authors: Usher Susan , Denis Jean-Louis , Préval Johanne , Baker Ross , Chreim Samia , Kreindler Sara , Breton Mylaine , Côté-Boileau Élizabeth 
Published: August 2020

AbstractIn publicly funded health systems, reform efforts have proliferated to adapt to increasingly complex demands. In Canada, prior research (Lazaret al., 2013,Paradigm Freeze: Why is it so Hard to Reform Health Care in Canada?, McGill-Queen's Press) found that reforms at the end of the 20th century failed to change the fundamentals of the Canadian system based on physician independence and assured universal coverage only for medical and hospital services. This paper focuses on reforms since the turn of the millennium to explore the transformative capacities developed in seven provinces within this system architecture. Longitudinal case studies, based on scientific and grey literature, and interviews with key informants, trace the patterns of reform in each province and reveal five objectives that, to varying degrees, preoccupied reformers: (1) address chronic disease, (2) align health system actors with provincial objectives, (3) shift from hospital to community-based care, (4) integrate physicians, and (5) develop improvement capacities. The range of strategies adopted to achieve these objectives in different provinces is compared to identify emerging pathways of reform and extract lessons for future reformers. We find significant cross-learning between provinces, but also note an emergent dimension to reforms, where multiple strategies aggregate through time to create unique patterns, presenting their own set of possibilities and limitations for the future.
Broadening the application of health technology assessment in the Netherlands: a worthwhile destination but not an easy ride?
Authors: Enzing Joost J. , Knies Saskia , Boer Bert , Brouwer Werner B.F. 
Published: August 2020

AbstractCurrently, reimbursement decisions based on health technology assessments (HTA) in the Netherlands mostly concern outpatient pharmaceuticals. The Dutch government aspires to broaden the systematic application of full HTA towards other types of health care in order to optimise the content of the basic benefit package. This paper identifies important challenges for broadening the scope of full HTA to other types of health care. Based on a description of the Dutch reimbursement decision-making process, five important characteristics of outpatient pharmaceuticals were identified, which are all relevant to the successful application of HTA: (i) closed reimbursement system, (ii) absence of alternative policy measures, (iii) existence of marketing authorisation, (iv) identifiable and accountable counterparty, and (v) product characteristics. For a selection of other types of health care, which may be subject to HTA more frequently in the future, deviations from these characteristics of outpatient pharmaceuticals are discussed. The implications of such deviations for performing HTA and the decision-making process are highlighted. It is concluded that broadening the application of HTA will require policy makers to meet both important policy-related and methodological challenges. These challenges differ per health care domain, which may inform policy makers which expansions of the current use of HTA are most feasible.