bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trust is the engine of change: A conceptual model for trust building in health systems
Authors: Adam Mary B. , Donelson Angela Joy 
Published: January 2020

Abstract
Background: Physicians, health care organizations, governments and communities are increasingly interested in how trust is built throughout the health system. Current science on building trust draws on diverse literature from business and consumer science to healthcare, and theory development has predominately focused on factor based models. We propose a process based theoretical model for trust building which may better reflect the complex and dynamic nature of trust itself. In doing so, we propose a new measurable dimension of the trust building process: reciprocity cycles. Cooperative reciprocal relationships are its building blocks, enabling stakeholders to “try out” their interactions with less risk, and to calibrate their level of effort, time and emotional investment. Reciprocity cycles includes three measurable elements: common goals, self-interests and gratitude/indebtedness.Methods: We applied the model, developing outcomes and measures in close-to-community health partnerships in Kenya. A 3-day workshop designed to stimulate problem solving and collaborative teamwork using human centered design principles was offered in 2 community health units in diverse contexts (rural agrarian and peri-urban flower farm slum), each with about 30 community health volunteers (CHVs) serving a population of approximately 5,000. Each unit formed separate teams representing specific villages; we followed these 9 teams between 18 to 24 months.Results: All 9 volunteer CHV teams delivered on self-directed public health outcomes across the spectrum of social determinants of health over the follow up period, with no funding, only using their own locally available resources. Projects were diverse, including immunization, composting toilets, hygiene, neonatal and reproductive health and public gardening. All 9 teams demonstrated trust building reciprocity cycles with articulation of common goal, self-interest, and gratitude/indebtedness. Conclusion: A process model of trust building, defined by reciprocity cycles, can be stimulated with a short intervention (illustrated here in close-to-community health systems) resulting in trusting relationships that drive agency and co-production of positive outcomes for health systems. In addition, it offers a simpler, more useful framework for trust building and measurement than traditional models of trust in health systems research. Early findings illustrate reciprocity cycles are scalable and adaptable, with potential utility at multiple levels of health systems.
A Missed Opportunity to Prevent Subsequent Fractures Confirmed through Trends in the Treatment of Osteoporosis in Patients with Distal Radius and Hip Fractures
Authors: Kim Dae-Geun , Jang Hae-Dong , Seo Gi-Won , Lee Hyun-Uk , Nam Hye-Won 
Published: January 2020

Abstract
Background A history of osteoporotic fracture (OF) is strongly associated with subsequent OFs. It is important to treat osteoporosis following OFs to prevent subsequent fractures. A distal radius fracture (DRF) is the most common type of OF in people in their 50s and could be a hallmark of future OFs. We compared the rate of osteoporosis treatment within 6 months post-DRF with hip fracture (HF). Methods We used data from the Korean Health Insurance Review and Assessment Service nationwide claims database from 2010 to 2016. International Classification of Diseases 10th revision (ICD-10) codes and procedures codes were used to identify patients older than 50 years with newly diagnosed DRFs and HFs. Then the rate of prescription and kinds of osteoporosis medications in these patients were analysed. We also compared the trends in both groups using the Cochran–Armitage trend test. Results A database search identified 77,209 DRFs and 72,044 HFs in patient aged 50 years or older from 2011 to 2016. Insufficient DRF and HF patients had osteoporosis medications (17.2% and 34.5%) and the numbers of osteoporosis medication for both DRFs and HFs decreased significantly annually ( P <0.0001). Bisphosphonates were used most often, although the use of selective oestrogen receptor modifiers (SERMs) increased gradually in both groups.Conclusions Clinicians who treat OFs should treat osteoporosis to prevent subsequent fractures and pay more attention to DRF patients who fail to get proper osteoporosis treatment.
Existence of multilineage mesenchymal progenitor cells in human atrophic nonunion tissue
Authors: Zhang Xianghong , Tang Zhongwen , Wan Jia , Jiang Guangyao , Yang Daishui , Zhang Xiangsheng , Liu Tang 
Published: January 2020

Abstract
Background : Though the treatment of atrophic nonunion is often challenging, bone union may occurs in some patients with atrophic nonunion who underwent indirect treatment at the docking site. We aimed at explaining the reasons why does this phenomenon appear? Methods : Five patients diagnosed with atrophic nonunion were enrolled in our study. Nonunion tissues were cut into strips and cultured immediately after being obtained. We got the adherent cells from atrophic nonunion tissues, and applied the flow cytometry to assess the expression of different cell-surface protein. The research in differentiation of the adherent cells was carried out under the induction of various lineage-specific factors, and Western-blot analysis was used to measure the differentiation-related protein expression. Results : We found that the adherent cells from atrophic nonunion tissues have the characteristics similar to bone marrow stromal cells. These traits demonstrated by the flow cytometry consist of positive expression of markers CD29 and CD44, but negative expression of CD34 and CD45. The adherent cells could differentiate into osteogenic, chondrogenic, and adipogenic cells under the different lineage-specific induction factors in vitro. Alkaline Phosphatase (ALP), Col Ⅱ, osteocalcin (OC), SOX9, lipoprotein lipase (LPL) and PPAR-γ2 were high expressed, as measured by Western-blotting. Conclusions : Mesenchymal stem cells obtaining from atrophic nonunion tissues have the potential of transforming into cartilage and bone-forming cells. Furthermore, we get conclusion that the atrophic nonunion tissues play an important role in the healing process.
MicroRNAs in small extracellular vesicles indicate successful embryo implantation during early pregnancy
Authors: Tan Qiang , Shi Shuang , Liang Jingjie , Zhang Xiaowei , Cao Dingren , Wang Zhengguang 
Published: January 2020

Abstract

Background : Synchronous communication between the developing embryo and the receptive endometrium is required for successful embryo implantation. Assessing of uterine receptivity is important for overcoming the recurrent implantation failure (RIF). Although the potential roles of small extracellular vesicles (sEVs) miRNAs in pregnancy have repeatedly mentioned, the systematic study of sEVs derived from endometrium and its cargoes during the implantation have not yet been reported. Methods : In this study, sEVs were isolated from mouse uterine cavity on D2 (pre-receptive phase), D4 (receptive phase) and D5 (implantation) of pregnancy using ultracentrifugation and analyzed by transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). The miRNAs expression profiles of sEVs were identified by RT-qPCR. The datasets analysis of RIF were employed by an integrative bioinformatics analysis. The protein markers of sEVs were examined by western blotting. The effects of miRNAs in embryo implantation were determined by an agomir injection test. Results : Here we show that the number of multivesicular bodies (MVBs) in the endometrium is increased during the window of implantation (WOI). Meanwhile, the expression of CD63 is mainly located in the luminal and glandular epithelium. sEVs miRNAs profile reveal that miR-34c-5p, miR-210, miR-369-5p, miR-30b and miR-582-5p are enriched during WOI. By further integrating the database analysis results of RIF, we found that miR-34c-5p regulates GAS1 to involve normal process of embryo implantation. It is interesting that miR-34c-5p is down-regulated during implantation but enriched in sEVs. An implication of this is the possibility that sEVs miR-34c-5p could be used to evaluate uterine states. Conclusion : Our study identified that mouse endometrium release sEVs during the early stage of pregnancy, especially during WOI. We found that miR-34c-5p in sEVs affects embryo implantation by targeting to GAS1. Furthermore, the sEVs miRNAs suggest potential biomarkers for the choose of suitable period for embryo implantation. This study also has a number of important implications for future practice.
ADAR expression and copy number variation in patients with advanced gastric cancer
Authors: Behroozi Javad , Shahbazi Shirin , Bakhtiarizadeh Mohammad Reza , Mahmoodzadeh Habibollah 
Published: January 2020

Abstract
Background Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteria and they may not result in an accurate prognosis. The aim of this study is to evaluate expression and copy number variation of the ADAR gene in advanced GC and clarify its correlation with survival and histopathological characteristics. Methods Forty two patients with stage III and IV GC were included in this study. ADAR gene expression and copy number variation were measured by real-time PCR and Quantitative multiplex ﬂuorescent-PCR, respectively. Survival analysis performed based on the Kaplan–Meier method and Mantel–Cox test. Results ADAR mRNA was significantly overexpressed in the tumor tissues when compared to the adjacent normal tissues (p <0.01). Also, ADAR expression level in stage IV was higher than stage III. 40% of patients showed amplification in ADAR gene and there was a positive correlation between ADAR copy number and expression. Increased ADAR expression was clearly correlated with poorer survival outcomes and Mantel–Cox test showed statistically significant differences between low and high expression groups (p <0.0001). ADAR overexpression and amplification were significantly associated with metastasis, size and stage of tumor. Conclusions Together, our data indicate that amplification leads to over expression of ADAR and it could be used as a prognostic biomarker for disease progression, especially for the metastatic process in GC. Keywords Gastric cancer, ADAR gene, Overexpression, Amplification, Prognosis
”I Am Satisfied with My Marriage”: An Experience from Madurese Women who Married Early
Authors: Bawono Yudho , Suminar Dewi Retno , Hendriani Wiwin 
Published: January 2020

The research aimed at examining ways by which Madurese women could achieve satisfaction in early marriage. Its used a qualitative research method with an interpretative phenomenological analysis (IPA). To understand the meaning of one’s experience by looking for themes from available data, IPA rested on three pillars, namely phenomenology, hermeneutics, and idiography. The researchers used semi-structured interviews to collect data and purposive homogeneous sampling. The participants involved were three married women under 18 years old who were living in Madura. The results of the research show that the three women are satisfied with their marriage. The satisfaction of their marriage can be seen from taking care of each other when sick, giving her enough money, and always happy with her husband, not far apart. Furthermore, Madurese women dissatisfaction in her marriage can be seen from anger if she is not given money and is not helped in doing household.
PREMENSTRUAL SYNDROME: CLINICAL PATTERN, DIAGNOSTICS AND THERAPEUTIC APPROACHES
Authors: Guliyeva L. P. , Yureneva S. V. 
Published: January 2020

Premenstrual syndrome (PMS) is a complex, cyclical, polyethiological, multifactorial combination of physical and mental disorders that occur in some women of reproductive age in the second - luteal - phase of the menstrual cycle and negatively affect the woman’s usual lifestyle.Premenstrual dysphoric disorder (PMDD) is a severe form of PMS in which psychoneurological symptoms prevail. For the diagnosis of PMDD, the specific DSM-5 criteria were developed by the American Psychiatric Association according to which the the diagnosis is confirmed by the presence of five or more symptoms in women during the week prior to menstruation and their disappearance a few days after the onset of menstruation. These symptoms are observed for at least two cycles.Treatment of women with PMS/PMDD, first of all, should start with the lifestyle adjustment, inclusion of regular mode rate physical activity into daily activities. The effectiveness of vitamins B6, E and calcium has not been confirmed in studies. First-line drug therapy includes SSRIs or combined oral contraceptives containing drospirenone are prescribed first, then agonists of gonadotropin-releasing hormone.
USING RESULTS OF FIRST-TRIMESTER BIOCHEMICAL SCREENING AND UTERINE ARTERY PULSATILITY INDEX FOR INCLUSION IN RISK GROUPS FOR FETAL GROWTH RESTRICTION
Authors: Zamaleeva R. S. , Cherepanova N. A. , Frizin D. V. , Frizina A. V. 
Published: January 2020

Objective: to study the combined use of first-trimester biochemical screening results and uterine artery pulsality index (PI) for inclusion in risk group for fetal growth restriction (FGR), improvement of pregnancy outcomes in women from the risk group for the development of FGR.Material and methods. The work is based on the results of studies conducted from 2009 to 2014 in the maternity unit of Republican Clinical Hospital № 2 MoH in the Republic of Tatarstan which is the clinical facility for the Department of Obstetrics and Gynecology № 1 of the Continuing Medical Education Institution “Kazan State Medical University” MoH RF, and maternity unit and prenatal clinic of the Volzhskaya Central City Hospital in the Mari El Republic. First-trimester biochemical screening results and uterine artery PI were the basis for the formation of FGR risk groups. Pregnancy and delivery outcomes in 156 pregnant women with a risk for the development of FGR and in 25 healthy controls were evaluated. In order to improve the placental blood flow based on the proven safety profile, all women with FGR received dipyridamole in the II trimester of pregnancy for at least 3 weeks.Conclusion: concomitant decrease in PAPP-A MoM and increase in uterine artery PI provide the most valuable information for forecasting FGR. Administration of dipyridamole by women with FGR helps to improve placental blood flow, prevents degenerative changes in the placenta, and promotes live births even in III degree FGR.
PREBIOTIC CORRECTION IN BACTERIAL VAGINOSIS
Authors: Tikhomirov A. L. , Kazenashev V. V. , Sarsaniya S. I. , Tuskaev K. S. 
Published: January 2020

Increased interest to the vaginal microecosystems is largely due to the fact that the role of evolutionary formed microbial populations in this habitat lies not only in the maintenance of vaginal colonization resistance, but also in formation of microecological health of newborns, and consequently, the human population in general.The formation of the qualitative and quantitative composition of microflora is regulated by a complex mechanism of microbial interactions inside each of microecosystems and is controlled by physiological factors of the host organism in the dynamics of his life.
Cost-benefit of promising adaptations for resilient development in climate hotspots: evidence from lower Teesta basin in Bangladesh
Authors: Arfanuzzaman Md. , Hassan S. M. Tanvir , Syed Md. Abu 
Published: January 2020

AbstractIt is very likely that climate change will increase the frequency and intensity of extreme events such as floods, flash floods, storms, heat and cold waves, riverbank erosion, and drought in the river basin of Hindu Kush Himalayan (HKH) region. This could mean detrimental impacts to the poor and marginal people in the lower Teesta basin (LTB) in Bangladesh. Though adaptation involves financial costs, the farmers' practicing adaptation in LTB experience diminished crop loss and damage. This study was aimed at assessing the promising adaptation practices, their economic return, and social welfare in the LTB through an extended cost-benefit analysis. The study suggests that among the adaptations, shallow tube-well (STW) based irrigation practice in both sandy and loamy soil has the highest marginal adaptation cost (MAC) but the lowest benefit-cost ratio (BCR). The deep tube-well (DTW) based irrigation practice generates superior benefits to the farmers compared to the STW based farming due to initial establishment by the government which is very expensive. Maize farming as an alternate and less resource consumptive cropping produces nearly five times higher economic benefits than the costs which can be acknowledged as the most profitable and resilient adaptation option in the LTB. Though MAC is relatively low for the short-duration variety (SDV) rice among the promising adaptations, its economic profitability is 62% lower than that of the maize cultivation. However, having higher BCR the maize cultivation generates US$86 higher welfare to the farmers than the SDV rice which may strengthen the farmer's preference of maize cultivation over the SDV rice. It can be stated with high confidence that strategic adaptation planning, soft credit, technological advancement, and subsidized agricultural inputs will encourage the farmers to carry out adaptation options which may reduce climate-induced loss and damages for the farmers and build socio-economic resilience in the LTB and other similar areas of South Asia.
Upgrading water distribution networks to work under uncertain conditions
Authors: Marques J. , Cunha M. 
Published: January 2020

Abstract
This work presents a multicriteria approach to defining flexible solutions for reinforcing and renewing existing water distribution networks, considering uncertain future working conditions. Criteria related to financial, environmental and pipe failure assessment are proposed to evaluate alternative solutions and to identify the best-placed options to implement. The alternatives are obtained for a phased design scheme that enables midcourse corrections through changes in the network layout. The proposed framework has been demonstrated using a case study based on a water distribution network from the literature.
Implications for industrial application of bioflocculant demand alternatives to conventional media: waste as a substitute
Authors: Mohammed Jibrin Ndejiko , Wan Dagang Wan Rosmiza Zana 
Published: January 2020

AbstractThe biodegradability and safety of the bioflocculants make them a potential alternative to non-biodegradable chemical flocculants for wastewater treatment. However, low yield and production cost has been reported to be the limiting factor for large scale bioflocculant production. Although the utilization of cheap nutrient sources is generally appealing for large scale bioproduct production, exploration to meet the demand for them is still low. Although much progress has been achieved at laboratory scale, Industrial production and application of bioflocculant is yet to be viable due to cost of the production medium and low yield. Thus, the prospects of bioflocculant application as an alternative to chemical flocculants is linked to evaluation and utilization of cheap alternative and renewable nutrient sources. This review evaluates the latest literature on the utilization of waste/wastewater as an alternative substitute for conventional expensive nutrient sources. It focuses on the mechanisms and metabolic pathways involved in microbial flocculant synthesis, culture conditions and nutrient requirements for bioflocculant production, pre-treatment, and also optimization of waste substrate for bioflocculant synthesis and bioflocculant production from waste and their efficiencies. Utilization of wastes as a microbial nutrient source drastically reduces the cost of bioflocculant production and increases the appeal of bioflocculant as a cost-effective alternative to chemical flocculants.
Data-driven fault detection methods for detecting small-magnitude faults in anaerobic digestion process
Authors: Kazemi Pezhman , Giralt Jaume , Bengoa Christophe , Steyer Jean-Philippe 
Published: January 2020

AbstractEarly detection of small-magnitude faults in anaerobic digestion (AD) processes is a mandatory step for preventing serious consequence in the future. Since volatile fatty acids (VFA) accumulation is widely suggested as a process health indicator, a VFA soft-sensor was developed based on support vector machine (SVM) and used for generating the residuals by comparing real and predicted VFA. The estimated residual signal was applied to univariate statistical control charts such as cumulative sum (CUSUM) and square prediction error (SPE) to detect the faults. A principal component analysis (PCA) model was also developed for comparison with the aforementioned approach. The proposed framework showed excellent performance for detecting small-magnitude faults in the state parameters of AD processes.
Disclosure nos relatórios de sustentabilidade de empresas do novo mercado da Bovespa em consonância com os objetivos de desenvolvimento sustentável publicados pela ONU
Authors: Dos Reis Larissa , Rigo Vitor Paulo , Farinon Kemylli 
Published: January 2020

Objetivo: O objetivo do estudo foi analisar se os relatórios de sustentabilidade divulgados pelas empresas, listadas no segmento do novo mercado da BOVESPA, estão alinhados com os objetivos de desenvolvimento sustentável publicados pela ONU.
Metodologia: Foi utilizada uma metodologia de abordagem descritiva, com acesso documental nos relatórios publicados pelas empresas no ano de 2016 e análise qualitativa dos resultados.
Resultados: Os achados da pesquisa, mostra que uma empresa apresenta evidências dos 17 objetivos propostos pela ONU e 7 das 29 empresas estudadas obtiveram mais de 50% de incidência das informações. Infere-se que as empresas não estão em consonância com os objetivos da ONU, pois nem todas as organizações estudadas evidenciam, as ações que tomam no decorrer do ano para cumprir os objetivos, a grande maioria somente cita os indicadores, ou menciona que está disposta a fazer, sem efetivamente dizer o que está sendo feito para a busca de um desenvolvimento sustentável.
Contribuições do Estudo: O trabalho é relevante, pois na atualidade as empresas buscam cada vez mais espaço no mercado, tornando as práticas organizacionais mais importantes tendo em vista a busca por recursos e consumidores. Com isso, há uma pressão maior para que as empresas atendam de forma sistemática, as dimensões econômica, social e ambiental da sustentabilidade, e como ferramenta para melhorar esse entendimento, é importante conhecer se as publicações dos relatórios de sustentabilidade das empresas estão em consonância com os objetivos da ONU. Contudo, os achados permitem compreender que há desafios importantes na divulgação de informações, pois, limites impostos pelas características, segmento do negócio e estrutura organizacional fazem com que determinados indicadores não sejam abordados pelas empresas. Em situações específicas, a organização não possui de fato, dados a serem compartilhados em relação a determinado objetivo, por isso, os dados quantitativos de divulgação, precisam ser avaliados com cautela.