bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative genomics of Fusarium oxysporum f. sp. melonis strains reveals nine lineages and a new sequence type of AvrFom2
Authors: Sabahi Fatemeh , Sain Mara de , Banihashemi Zia , Rep Martijn 
Published: December 2020

SummaryFusarium oxysporum f. sp. melonis (Fom) is one of the most important pathogens of melon worldwide. In this study, we investigated the genomic diversity of Fom. One of the aims was to find clues for the origin(s) and dispersal of clonal lineages and races of Fom. We therefore included a large number of Fom strains from Iran, where melon has been cultivated for at least 5000 years. In 33 new genome sequences of Fom strains from different geographical regions of Iran and across the world, 40 new candidate effector genes were identified. Presence/absence of candidate effector genes and phylogenetic analyses resolved nine Fom lineages. The presence of a highly similar set of effector genes in some distant lineages is suggestive of horizontal chromosome transfer, a process known to occur in the Fusarium oxysporum species complex. Race 1.2, which breaks both Fom1 and Fom2 resistance genes, occurs in three of the nine lineages, two of which are predominant in Iran. We also identified a new sequence type of the AVRFom2 avirulence gene in one lineage. Expression of this sequence type during melon infection and genetic complementation suggest that this sequence type is not recognized by the Fom2 resistance protein.
A Strategic Left? Starmerism, Pluralism and the Soft Left
Authors: Thompson Paul , Pitts Frederick Harry , Ingold Jo 
Published: December 2020

AbstractThis article places the Labour Party’s present post‐Corbyn renewal in the context of previous periods of renewal in the party’s recent history, associating with the new leadership of Keir Starmer a potential to rediscover the strategic project of the pluralist soft left as an alternative to the programmatic character of the hard left. After assessing the Corbynist hegemony established in the Labour Party between 2015 and 2019, it considers the current absence of any clearly defined set of principles or values underpinning ‘Starmerism’. It then looks back to the Kinnockite ascendency in the 1980s, and the Blairite ascendency in the 1990s, as possible templates for how the party reassesses its positioning with reference to changing electoral, social and economic circumstances. A critique of Corbynism’s left populism culminates in a consideration of the possible grounds for a new pluralist agenda attuned to the policy and electoral challenges Labour faces today.
Costs of using evidence‐based implementation strategies for behavioral health integration in a large primary care system
Authors: Yeung Kai , Richards Julie , Goemer Eric , Lozano Paula , Lapham Gwen , Williams Emily , Glass Joseph , Lee Amy , Achtmeyer Carol , Caldeiro Ryan , Parrish Rebecca , Bradley Katharine 
Published: December 2020

AbstractObjectiveTo describe the cost of using evidence‐based implementation strategies for sustained behavioral health integration (BHI) involving population‐based screening, assessment, and identification at 25 primary care sites of Kaiser Permanente Washington (2015‐2018).Data Sources/Study SettingProject records, surveys, Bureau of Labor Statistics compensation data.Study DesignLabor and nonlabor costs incurred by three implementation strategies: practice coaching, electronic health records clinical decision support, and performance feedback.Data Collection/Extraction MethodsPersonnel time spent on these strategies was estimated for five broad roles: (a) project leaders and administrative support, (b) practice coaches, (c) clinical decision support programmers, (d) performance metric programmers, and (e) primary care local implementation team members.Principal FindingImplementation involved 286 persons, 18 131 person‐hours, costing $1 587 139 or $5 per primary care visit with screening or $38 per primary care visit identifying depression, suicidal thoughts and/or alcohol or substance use disorders, in a single year. The majority of person‐hours was devoted to project leadership (35%) and practice coaches (34%), and 36% of costs were for the first three sites.ConclusionsWhen spread across patients screened in a single year, BHI implementation costs were well within the range for commonly used diagnostic assessments in primary care (eg, laboratory tests). This suggests that implementation costs alone should not be a substantial barrier to population‐based BHI.
Application of natural‐based nanocoatings for extending the shelf life of green bell pepper fruit
Authors: Correa‐Pacheco Zormy Nacary , Corona‐Rangel María Luisa , Bautista‐Baños Silvia , Ventura‐Aguilar Rosa Isela 
Published: December 2020

AbstractPectobacterium carotovorum is a phytopathogenic bacteria that causes significant economic loses in food crops, such as bell pepper, which is of special significance in the value of production and trade in Mexico. Therefore, a solution for fruit conservation must be sought. Due to environmental concerns, it is necessary the use of environmentally‐friendly active packaging. In this article, chitosan and chitosan‐thyme essential oil nanocoatings were used for the preservation of green bell pepper. Different formulations based on chitosan nanoparticles (CSNPs) and chitosan‐thyme essential oil nanoparticles (15, 30, and 45%) were prepared. For uncoated and coated bell peppers, the quality and physiological variables of inoculated and uninoculated fruit with P. carotovorum during 12‐day storage period were assessed. According to the results, the weight loss of the fruit remained almost constant over the storage days for the different formulations. A decrease in fruit firmness and an increase in the respiration rate and ascorbic acid content until day 8 with a decrease at the end of the storage period were observed. Of all the evaluated nanocoatings, the fruit treated with the formulation containing 15% CSNPs showed the lowest colony‐forming units and disease incidence. Also, the coated bell peppers with this formulation had lower CO2 production compared to the remaining treatments, and the weight loss and firmness were maintained. Therefore, the use of CSNP coatings could represent a good alternative for the protection of bell pepper against the pathogenic bacteria P. carotovorum.Practical ApplicationThe results of the application of nanocoatings based on chitosan and chitosan‐thyme essential oil as an antibacterial agent against P. carotovorum on green bell pepper during 12‐day storage period suggest that nanoparticle‐based coatings can be a natural option for the preservation of fruit quality during ripening.
Shannon entropy as a robust estimator of Zipf's Law in animal vocal communication repertoires
Authors: Kershenbaum Arik , Demartsev Vlad , Gammon David E. , Geffen Eli , Gustison Morgan L. , Ilany Amiyaal , Lameira Adriano R. 
Published: December 2020

Abstract

Information complexity in animals is an indicator of advanced communication and an intricate socio‐ecology. Zipf's Law of least effort has been used to assess the potential information content of animal repertoires, including whether or not a particular animal communication could be ‘language‐like’. As all human languages follow Zipf's law, with a power law coefficient (PLC) close to −1, animal signals with similar probability distributions are postulated to possess similar information characteristics to language. However, estimation of the PLC from limited empirical datasets (e.g. most animal communication studies) is problematic because of biases from small sample sizes.

The traditional approach to estimating Zipf's law PLC is to find the slope of a log–log rank‐frequency plot. Our alternative option uses the underlying equivalence between Shannon entropy (i.e. whether successive elements of a sequence are unpredictable, or repetitive) and PLC. Here, we test whether an entropy approach yields more robust estimates of Zipf's law PLC than the traditional approach.

We examined the efficacy of the entropy approach in two ways. First, we estimated the PLC from synthetic datasets generated with a priori known power law probability distributions. This revealed that the estimated PLC using the traditional method is particularly inaccurate for highly stereotyped sequences, even at modest repertoire sizes. Estimation via Shannon entropy is accurate with modest sample sizes even for repertoires with thousands of distinct elements. Second, we applied these approaches to empirical data taken from 11 animal species. Shannon entropy produced a more robust estimate of PLC with lower variance than the traditional method, even when the true PLC is unknown. Our approach for the first time reveals Zipf's law operating in the vocal systems of multiple lineages: songbirds, hyraxes and cetaceans.

As different methods of estimating the PLC can lead to misleading results in real data, estimating the balance of a communication system between simplicity and complexity is best performed using the entropy approach. This provides a more robust way to investigate the evolutionary constraints and processes that have acted on animal communication systems, and the parallels between these processes and the evolution of language.
Archival research on audit partners: assessing the research field and recommendations for future research
Authors: Hardies Kris , Hossain Sarowar , Chapple Larelle (Ellie) 
Published: December 2020

AbstractIn this paper, we assess the existing archival research on audit partners and provide recommendations for future research. Our empirical analyses suggest that the audit partner characteristics with the biggest impact are industry specialisation and client importance. We demonstrate that audit partner studies may suffer from omitted variable bias if they study audit partner characteristics in isolation, as they have often done. We also show that, for most audit partner characteristics, there is little within‐company and within‐partner variation. We therefore caution against routinely including company and audit partner fixed effects in audit partner studies. We also examine the importance of properly adjusting for dependence in the data in audit partner studies and suggest to cluster standard errors at the client firm level. Finally, we provide detailed descriptive information at the audit partner level in order to demonstrate how researchers could improve the reporting of audit partner level data.
Clinical features and molecular genetics of patients with ABCA4‐retinal dystrophies
Authors: Holtan Josephine Prener , Aukrust Ingvild , Jansson Ragnhild Wivestad , Berland Siren , Bruland Ove , Gjerde Birgitt Løkhaug , Stokowy Tomasz , Bojovic Ognjen , Forsaa Vegard , Austeng Dordi , Rødahl Eyvind , Bredrup Cecilie , Knappskog Per Morten , Bragadóttir Ragnheiður 
Published: December 2020

AbstractPurposePathogenic variations in the ABCA4 gene are a leading cause of vision loss in patients with inherited retinal diseases. ABCA4–retinal dystrophies are clinically heterogeneous, presenting with mild to severe degeneration of the retina. The purpose of this study was to clinically and genetically characterize patients with ABCA4‐retinal dystrophies in Norway and describe phenotype–genotype associations.MethodsABCA4 variants were detected in 111 patients with inherited retinal disease undergoing diagnostic genetic testing over a period of 12 years. In patients where only a single ABCA4 variant was found, whole‐gene ABCA4 sequencing was performed and intronic variants were investigated by mRNA analyses in fibroblasts. Medical journals were used to obtain a clinical description and ultrawidefield autofluorescence images were used to analyse retinal degeneration patterns.ResultsThe genetic diagnostic yield was 89%. The intronic splice variant c.5461‐10T>C was the most prevalent disease‐causing variant (27%). Whole‐gene ABCA4 sequencing detected two novel intronic variants (c.6729+81G>T and c.6817‐679C>A) that we showed affected mRNA splicing. Peripheral retinal degeneration was identified in 33% of patients and was associated with genotypes that included severe loss of function variants. By contrast, peripheral degeneration was not found in patients with a disease duration over 20 years and genotypes including p.(Asn1868lle), c.4253+43G>A or p.(Gly1961Glu) in trans with a loss of function variant.ConclusionThis study demonstrates the clinical and genetic heterogeneity of ABCA4‐retinal dystrophies in Norway. Further, the study presents novel variants and increases our knowledge on phenotype–genotype associations and the presence of peripheral retinal degeneration in ABCA4‐retinal dystrophy patients.
Falls in individuals with type 2 diabetes; a cross‐sectional study on the impact of motor dysfunction, postural instability and diabetic polyneuropathy
Authors: Khan Karolina S. , Pop‐Busui Rodica , Devantier Louise , Kristensen Alexander G. , Tankisi Hatice , Dalgas Ulrik , Overgaard Kristian , Andersen Henning 
Published: December 2020

AbstractAimTo estimate the incidence of falls in individuals with type 2 diabetes compared to healthy controls and to describe the characteristics of fallers with type 2 diabetes in relation to motor dysfunction, postural instability and diabetic polyneuropathy (DPN).MethodsThis is a cross‐sectional study of individuals with type 2 diabetes with DPN (n = 54), without DPN (n = 38) and healthy controls (n = 39). Falls were recorded within the preceding year. DPN was defined by clinical scores and nerve conduction studies. Motor function was assessed by a 6‐min walk test (6 MWT), five‐time sit‐to‐stand test (FTSST) and isokinetic dynamometry at the non‐dominant ankle and knee. An instability index (ST) was measured using static posturography. Univariate and bivariate descriptive statistics were used for group comparisons.ResultsCompared with healthy controls, individuals with diabetes had a higher incidence of falls 36%, (n = 33) versus 15%, (n = 6), p = 0.02. There were no differences in falls when comparing individuals with and without DPN. Fallers had an impaired 6 MWT versus non‐fallers (450 ± 153 m vs. 523 ± 97 m respectively), a slower FTSST (11.9 ± 4.2 s vs. 10.3 ± 2.9 s respectively) and a higher ST (53 ± 29 vs. 41 ± 17 respectively), p < 0.02 for all.ConclusionIndividuals with type 2 diabetes reported a higher number of falls within the preceding year compared to healthy controls, irrespective of the presence of DPN. The main factors associated with falls were increased postural instability, lower walking capacity and slower sit‐to‐stand movements. The 6 MWT, FTSST and posturography should be considered in future screening programs in identification of individuals at risk for falls.
Acute suprarenal occlusion in an American Miniature Horse
Authors: Cuillé O , Bodaan C. J. , Brown S. , Riley C. B. , Munday J. S. , Mack S. J. 
Published: December 2020

SummaryA 7‐month‐old Miniature filly was examined because of a 4‐day history of abnormal posture, lethargy and weakness. On initial evaluation, the filly presented with an abnormal stiff gait in her hindlimbs associated with hindlimb ataxia and lumbar kyphosis. She showed hindlimb discomfort by weight shifting from one hindlimb to the other. A complete blood count revealed an acute inflammatory leukogram associated with hyperfibrinogenaemia. The measurement of the serum amyloid A concentration indicated anactive inflammatory process. Biochemistry and urinalysis results revealed a severe azotaemia associated with diluted urine despite clinical dehydration, consistent with acute renal failure. Medical treatment was initiated with fluid therapy and antimicrobials. The pain was managed with morphine sulphate only, to avoid further kidney damage. The filly maintained an abnormal gait during this time, became progressively more ataxic and uncomfortable, and developed colic episodes. Because the horse was unresponsive to pain management, euthanasia was elected by the client. Post‐mortem examination revealed an occlusive thrombus within the abdominal aorta, firmly attached to the intima, partially recanalised and extending from the aorta 1 cm along the right renal artery. In the left and right kidneys, severe subacute neutrophilic pyelonephritis, with lymphoplasmacytic interstitial nephritis was noted. In the hindlimb muscles, multifocal myocyte necrosis and evidence of regeneration was present. To the authors’ knowledge, this is the first case of acute suprarenal occlusion to be described in a horse.
ENLIGHTENMENT, INFORMATION, AND THE COPERNICAN DELAY: A VENTURE INTO THE HISTORY OF KNOWLEDGE
Authors: SISKIN CLIFFORD 
Published: December 2020

ABSTRACTThis essay pursues the history of knowledge in the form of what Francis Bacon called a “literary history”—a “story of learning” that tracks “the antiquities and originals of knowledges.” It focuses on the changing interrelations of information and knowledge from the seventeenth century to the present day in order to identify a fundamental continuity in a knowledge project that links the Enlightenment to our own era of quantum computation. At the core of that project has been Bacon's and Robert Boyle's dreams of re‐making the world through a “handshake” between the intellectual and physical worlds. Quantum theory tells us that the lingua franca that realizes that handshake is information. I track that realization from the simultaneous emergence of newspapers and modern science 350 years ago to today's moment of fake news and quantum computation. In doing so, I identify a feature of the history of knowledge that is applicable to other ventures into that history: a taxonomy of “delays” in explanatory knowledge caused by mismatches between concepts and technologies.
The efficacy of synthetic pseudo‐ceramide for dry and rough lips
Authors: Tamura E. , Ishikawa J. , Yasuda Y. , Yamamoto T. 
Published: December 2020

AbstractOBJECTIVELips can easily become dry and rough, one reason being the characteristics of their ceramide (CER) profile. Lips have lower levels of total ceramides, higher percentages of CER[NS] and CER[AS], and lower percentages of CER[NP] and CER[NH] than skin in other regions of the body. The purpose of this study was to clarify the effects of synthetic pseudo‐ceramide (pCer; Cetyl‐PG hydroxyethyl palmitamide) to improve the dryness and roughness of the lips of healthy subjects in a formulation that exclude an occlusive effect.METHODSThirty‐one Japanese female subjects with normal skin (age range 21–37 years; mean 28.6) were enrolled in this study. A four‐week continuous use test was conducted using samples with or without 0.5% or 2.0% pCer. The degree of lip roughness was scored, and values of capacitance, transepidermal water loss (TEWL) and lip surface elasticity were measured. Endogenous CER profiles and absorption levels of pCer in the stratum corneum (SC) were analysed in tape‐stripped skin specimens.RESULTSTreatment with the pCer‐2.0% sample significantly improved the visual roughness score after 2 and 4 weeks compared to 0 weeks and compared to the Blank. Moreover, an improvement in TEWL was observed after 4 weeks of treatment with the pCer‐2.0% sample. CER[NP] showed a significant increase in pCer‐2.0% treated lips after 4 weeks compared to the Blank. Both pCer‐0.5% and pCer‐2.0% were significantly absorbed after 2 weeks compared with the Blank.CONCLUSIONThe effect of the synthetic pseudo‐ceramide pCer to improve the roughness of lips was shown excluding the effect of occlusiveness derived from the formulation for the first time. Since the improvement of TEWL and absorption of pCer was observed, we concluded that pCer was first absorbed in rough lip areas, improved the ceramide profile and consequently restored the barrier function.
HOMEOWNERSHIP AND HOUSING TRANSITIONS: EXPLAINING THE DEMOGRAPHIC COMPOSITION
Authors: Ma Eunseong , Zubairy Sarah 
Published: December 2020

AbstractWe document the evolution of homeownership rate across various age groups for the period 1995–2015. We find that variations in the homeownership rates are relatively large for the young, which is mostly driven by renter‐to‐owner transitions. In order to explain these empirical facts, we consider a life‐cycle model featuring housing tenure decisions. Housing is modeled as an indivisible and lumpy investment subject to both loan‐to‐value (LTV) and debt‐to‐income (DTI) credit constraints and transaction fees. Our analysis suggests that variations in the DTI limit play a crucial role in accounting for the uneven behavior across age groups.
Skin and eye protection against ultraviolet C from ultraviolet germicidal irradiation devices during the COVID‐19 pandemic
Authors: Lyons Alexis B. , Narla Shanthi , Torres Angeli E. , Parks‐Miller Angela , Kohli Indermeet , Ozog David M. , Lim Henry W. , Hamzavi Iltefat H. 
Published: December 2020

AbstractWith the COVID‐19 pandemic depleting personal protective equipment worldwide, various methods including ultraviolet C (UVC) germicidal irradiation (UVGI) have been implemented to decontaminate N95 filtering facepiece respirators. These devices pose a risk for UVC exposure to the operator with reported adverse effects generally limited to the eyes and skin. Our hospitals are currently using UVC devices for N95 decontamination with a few reported cases of face and neck erythema from exposure. Because sunscreens are designed and tested for UVA and UVB protection only, their effects on blocking UVC are largely unknown. Therefore, our objective was to determine if various sunscreens, UV goggles, and surgical mask face shields minimize UVC exposure from UVGI devices. Our study clearly demonstrated that healthcare workers responsible for the disinfection of PPE using UVGI devices should always at least utilize clear face shields or UV goggles and sunscreen to protect against side effects of UVC exposure.
Metabolic and sympathovagal effects of bolus insulin glulisine versus basal insulin glargine therapy in people with type 2 diabetes: A randomized controlled study
Authors: Takeshita Yumie , Tanaka Takeo , Wakakuri Hitomi , Kita Yuki , Kanamori Takehiro , Takamura Toshinari 
Published: November 2020

AbstractAims/IntroductionThis study compares the effects of two different insulin regimens – basal versus bolus insulin – on metabolic and cardiovascular autonomic function in Japanese participants with type 2 diabetes.Materials and MethodsParticipants were randomly assigned to groups for therapy with insulin glulisine (IGlu) or insulin glargine (IGla). The primary efficacy end‐point was glycemic variability, including M‐values, mean of glucose levels, and a blood glucose profile of seven time points before and after the intervention. The secondary end‐points included pleiotropic effects, including endothelial and cardiac autonomic nerve functions.ResultsBlood glucose levels at all time points significantly decreased in both groups. Post‐lunch, post‐dinner, and bedtime blood glucose levels were significantly lower in the IGlu group than in the IGla group. Nadir fasting blood glucose levels at the end‐point were significantly lower in the IGla group than in the IGlu group. The M‐value and mean blood glucose levels were significantly decreased from baseline in both groups, although the former was significantly lower in the IGlu group than in the IGla group. IGla, but not IGlu, was found to elevate 24‐h parasympathetic tone, especially during night‐time, and it decreased 24‐h sympathetic nerve activity, especially at dawn.ConclusionsBoth IGlu and IGla regimens reduced glucose variability, with IGlu bringing a greater reduction in M‐value. IGla, but not IGlu, increased parasympathetic tone during night‐time and decreased sympathetic nerve activity at dawn. These findings shed light on the previously unrecognized role of night‐time basal insulin supplementation on sympathovagal activity in type 2 diabetes patients.