bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatio-temporal patterns of pre-eclampsia and eclampsia in relation to drinking water salinity at the district level in Bangladesh from 2016 to 2018
Authors: Pinchoff Jessie , Shamsudduha Mohammad , Hossain Sharif Mohammed Ismail , Shohag Abdullah Al Mahmud , Warren Charlotte E. 
Published: November 2019

AbstractThis analysis examines whether salinity in drinking water is associated with pre-eclampsia and eclampsia (PE/E), a leading cause of maternal morbidity and mortality. Bangladesh’s national health information system data were extracted at the district level (n = 64) to assess PE/E rates, and these were overlaid with three environmental measures approximating drinking water salinity, remotely sensed low-elevation coastal zone (LECZ), monthly rainfall data, and electrical conductivity of groundwater (i.e., water salinity). Results from a negative binomial fixed effects model suggest PE/E rates are higher with less rainfall (dry season), lower population density, and that district level rates of PE/E increase with higher groundwater salinity and in the high risk LECZ category closest to the coast. Results suggest that drinking water salinity may be associated with PE/E and that using national health surveillance data can improve understanding of this association. This approach can potentially be leveraged in the future to inform targeted interventions to high risk regions and times.
Mechanochemical Forces as a Synthetic Tool for Zero- and One-Dimensional Titanium Oxide-Based Nano-photocatalysts
Authors: Giannakoudakis Dimitrios A. , Chatel Gregory , Colmenares Juan Carlos 
Published: November 2019

Abstract
A new field where the utilization of mechanochemistry can create new opportunities is materials chemistry, and, more interestingly, the synthesis of novel nanomaterials. Ball-milling procedures and ultrasonic techniques can be regarded as the most important mechanochemical synthetic tools, since they can act as attractive alternatives to the conventional methods. It is also feasible for the utilization of mechanochemical forces to act synergistically with the conventional synthesis (as a pre-treatment step, or simultaneously during the synthesis) in order to improve the synthetic process and/or the material’s desired features. The usage of ultrasound irradiation or ball-milling treatment is found to play a crucial role in controlling and enhancing the structural, morphological, optical, and surface chemistry features that are important for heterogeneous photocatalytic practices. The focus of this article is to collect all the available examples in which the utilization of sonochemistry or ball milling had unique effects as a synthesis tool towards zero- or one-dimensional nanostructures of a semiconductor which is assumed as a benchmark in photocatalysis, titanium dioxide.

Graphical Abstract
How Moral Facts Cause Moral Progress
Authors: LUCO ANDRÉS 
Published: November 2019

AbstractMorally progressive social changes seem to have taken place with the onset of democratic governance, the abolition of slavery, the rise of gender equality, and other developments. This essay attempts to demonstrate that natural and objective moral facts are a plausible cause of some morally progressive social changes. Since this hypothesis is a version of naturalistic moral realism, I call it the Naturalist-Realist Hypothesis (NRH). To support the NRH, I argue that objective moral facts are natural facts pertaining to the impartial promotion of well-being within a population of agents facing a social dilemma. I then describe a mechanism to explain how natural and objective moral facts so construed may cause some morally progressive social changes. I suggest that the NRH is a credible hypothesis because it is compatible with empirical findings from research on the evolution of moral cognition and on the sociology of mass political movements.
Assessing clinical research coordinator knowledge of good clinical practice: An evaluation of the state of the art and a test validation study
Authors: DuBois James M. , Mozersky Jessica T. , Antes Alison L. , Baldwin Kari , Jenkerson Michelle 
Published: November 2019

AbstractThis paper describes the development and validation of a new 32-item test of knowledge of good clinical practice (GCP) administered to 625 clinical research coordinators. GCP training is mandated by study sponsors including the US National Institutes of Health. The effectiveness of training is rarely assessed, and the lack of validated tests is an obstacle to assessment. The GCP knowledge test was developed following evaluation of two existing widely used GCP tests to ensure it accurately reflects the content of current training. The final GCP knowledge test demonstrated good reliability (α = 0.69). It is a valid and reliable instrument for measuring knowledge of GCP. The test will be useful in assessing the effectiveness of GCP training programs as well as individuals’ mastery of GCP content.
Fitting geothermal energy into the energy transition
Authors: Smith Daniel P. 
Published: November 2019

Abstract
This article attempts to identify the main ‘above-ground’ factors which impact on the contribution that geothermal energy can make to the Dutch Energy Transition, and to draw conclusions about these factors. Recent literature sources are used to illustrate the size of Dutch heating demand, and the part of this which can be provided by geothermal energy. Consideration is given to the impact of off-take variability over time, showing that the base-load nature of geothermal doublets acts as a restraint on the share which they can take in the energy supply. The characteristics of district heating grids are discussed. Other potential sources of heat are considered and compared.
The conclusion is that geothermal energy can provide a material contribution to the energy transition. This depends to a large extent on the existence of and design choices made for the development of district heating networks. Large size and standardisation, and the development of seasonal heat storage, are beneficial.
Unlike most other renewable sources of heat, which have alternative ‘premium’ applications such as the provision of ‘peak capacity’ or molecules for feedstock, geothermal energy is not suitable for other uses. The emission savings that it can provide will be lost if other heat sources are chosen in preference as supply for district heating, so that it makes sense that district heating infrastructure should be designed to encourage the use of geothermal energy where possible.
Treatment planning for non-small cell lung tumours: VMAT versus 3DCRT a quantitative dosimetric study
Authors: Hadj Henni Ahmed , Lauzin Yann , Pirault Nicolas , Dubos Brian , Roge Maximilien , Clarisse Perrine , Gensanne David , Thureau Sebastien 
Published: November 2019

AbstractPurpose:The dosimetric impact of volumetric modulated arc therapy (VMAT) in lung cancer compared with 3D conformal radiotherapy (3DCRT) is well known. However, this improvement is often associated with an increase in low doses. The aim of this study is to quantify these results more accurately.Methods:For each patient treated with 3DCRT, a second VMAT treatment plan was calculated. Usual dosimetric parameters such as target coverage or dose to the organs at risk were used to achieve the comparisons.Results:For planning target volume, homogeneity and conformity indices showed superiority of VMAT (respectively 0·07 and 0·87) compared to 3DCRT (0·11 and 0·57). For spinal cord planning organ at risk volume, the median maximum dose was 45·6 Gy in 3DCRT against 19·3 Gy in VMAT. Heart volume receiving at least 35 Gy (V35) decreased from 15·64% in 3DCRT to 8·28% in VMAT. Oesophagus V50 was higher in 3DCRT (25·45%) than in VMAT (14·03%). The mean lung dose was 17·9 Gy in 3DCRT versus 15·5 Gy in VMAT. Moreover, volumes receiving 5, 10 and 15 Gy were not significantly different between the two techniques when VMAT was performed with partial arcs.Conclusion:All the dosimetric parameters were improved with VMAT compared to the 3DCRT without increasing low doses when using partial arcs.
ENSO Modulation of MJO Teleconnections to the North Atlantic and Europe
Authors: Lee R. W. , Woolnough S. J. , Charlton‐Perez A. J. , Vitart F. 
Published: November 2019

AbstractThe teleconnection from the Madden‐Julian Oscillation (MJO) provides a source of subseasonal variability and predictability to the North Atlantic‐European (NAE) region. The El Niño‐Southern Oscillation (ENSO) modulates the seasonal mean state, through which the MJO and its teleconnection pattern propagates; however, its impact on this teleconnection to the NAE region has not been investigated. Here we find a robust dependence of the teleconnections from the MJO to NAE weather regimes on the phase of ENSO. We show that the MJO to NAO+ regime tropospheric teleconnection is strongly enhanced during El Niño years, via enhanced Rossby wave activity, and suppressed during La Niña. Conversely, the MJO to NAO− regime stratospheric teleconnection is enhanced during La Niña years and suppressed during El Niño. This dependence on the background state has strong implications for subseasonal predictability, including interannual variations in subseasonal predictive skill.
Accuracy of transcutaneous bilirubin on covered skin in preterm and term newborns receiving phototherapy using a JM-105 bilirubinometer
Authors: Costa-Posada U. , Concheiro-Guisán A. , Táboas- Ledo M. F. , González-Colmenero E. , González-Durán M. L. , Suarez-Albo M. , Duran Fernández-Feijoo C. , Pumarada-Prieto M. , Martínez-Reglero Cristina , Fernández-Lorenzo J. R. 
Published: November 2019

Abstract
Objective
Determine the suitability of transcutaneous bilirubin (TCB) as a tool to assess the effectiveness of phototherapy on patched skin.

Study design
A prospective observational study was conducted. We covered a fragment of skin (sternum) with a photo-opaque patch. Several simultaneous TCB and TSB measurements were performed with the JM-105 bilirubinometer. Bland and Altman test evaluated the agreement between bilirubin levels.

Result
A total of 217 patients were studied, 48.8% were preterm. The mean difference between TSB and TCB before the start of treatment was 1.07 mg/dL. During phototherapy, differences on covered skin were 0.52, 0.27, and 0.39 mg/dL at 24, 48, and 72 h of therapy respectively. The best correlation was observed at 48 h in preterm infants.

Conclusion
The measurement of TCB on patched skin (PTCB) is useful for monitoring the response to phototherapy in term and preterm infants. We use a patch with a removable flap that eases successive measures without disturbing the patients.
MicroRNA-155-5p is a key regulator of allergic inflammation, modulating the epithelial barrier by targeting PKIα
Authors: Wang Xiaoyu , Chen Yanyan , Yuan Weiyuan , Yao Lu , Wang Siqi , Jia Zhirong , Wu Peng , Li Lianqu , Wei Pan , Wang Xiaotong , Hong Min 
Published: November 2019

AbstractRecent studies have demonstrated that microRNA-155-5p (miR-155-5p) plays an essential role in the regulation of allergen-induced inflammation and is overexpressed in the skin of patients with atopic dermatitis (AD), although the mechanism is unknown. In this study, silencing miR-155-5p attenuated the thickening of the epidermis in AD model and reduced the infiltration of inflammatory cells and the secretion of Th2 cytokines. Protein kinase inhibitor α (PKIα) was identified as a direct target of miR-155-5p and correlated negatively with miR-155-5p in our AD model. Fluorescence in situ hybridization showed that miR-155-5p-expressing cells were predominantly present in the epidermis. When epithelial cells were transfected with an miR-155-5p inhibitor, the expression of PKIα, occludin, and CLDN16 increased and that of TSLP decreased significantly, whereas the overexpression of miR-155-5p resulted in the opposite changes. The increased expression of PKIα and tight junction (TJ) proteins, with reduced TSLP and IL-33, was also detected in miR-155-5p-blocked mice, in both the initial and elicitation stages of AD. The expression of TJ proteins also decreased when cells were transfected with PKIα siRNA. TJ proteins increased and TSLP and IL-33 decreased significantly after the overexpression of PKIα. Our data provide the first evidence that miR-155-5p is critical for the allergic inflammation in a mouse model of AD by directly regulating PKIα and thus epithelial TJ expression. These findings suggest new therapeutic strategies that target miR-155-5p in patients with allergic disorders.
Knockdown of cytokeratin 8 overcomes chemoresistance of chordoma cells by aggravating endoplasmic reticulum stress through PERK/eIF2α arm of unfolded protein response and blocking autophagy
Authors: Wang Di , Zhang Peiran , Xu Xiaolong , Wang Jianhui , Wang Dong , Peng Pandi , Zheng Chao , Meng Qing-Jun , Yang Liu , Luo Zhuojing 
Published: November 2019

AbstractChordoma is a malignant primary osseous spinal tumor with pronounced chemoresistance. However, the mechanisms of how chordoma cells develop chemoresistance are still not fully understood. Cytokeratin 8 (KRT8) is a molecular marker of notochordal cells, from which chordoma cells were believed to be originated. In this study, we showed that either doxorubicin or irinotecan promoted KRT8 expression in both CM319 and UCH1 cell lines, accompanied by an increased unfolded protein response and autophagy activity. Then, siRNA-mediated knockdown of KRT8 chemosensitized chordoma cells in vitro. Mechanistic studies showed that knockdown of KRT8 followed by chemotherapy aggravated endoplasmic reticulum stress through PERK/eIF2α arm of unfolded protein response and blocked late-stage autophagy. Moreover, suppression of the PERK/eIF2α arm of unfolded protein response using PERK inhibitor GSK2606414 partially rescued the apoptotic chordoma cells but did not reverse the blockage of the autophagy flux. Finally, tumor xenograft model further confirmed the chemosensitizing effects of siKRT8. This study represents the first systematic investigation into the role of KRT8 in chemoresistance of chordoma and our results highlight a possible strategy of targeting KRT8 to overcome chordoma chemoresistance.
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia
Authors: Papaioannou Dimitrios , Petri Andreas , Dovey Oliver M. , Terreri Sara , Wang Eric , Collins Frances A. , Woodward Lauren A. , Walker Allison E. , Nicolet Deedra , Pepe Felice , Kumchala Prasanthi , Bill Marius , Walker Christopher J. , Karunasiri Malith , Mrózek Krzysztof , Gardner Miranda L. , Camilotto Virginia , Zitzer Nina , Cooper Jonathan L. , Cai Xiongwei , Rong-Mullins Xiaoqing , Kohlschmidt Jessica , Archer Kellie J. , Freitas Michael A. , Zheng Yi , Lee Robert J. , Aifantis Iannis , Vassiliou George , Singh Guramrit , Kauppinen Sakari , Bloomfield Clara D. , Dorrance Adrienne M. , Garzon Ramiro 
Published: November 2019

AbstractLong non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of theHOXB-AS3lncRNA in patients withNPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show thatHOXB-AS3regulates the proliferative capacity ofNPM1mut AML blasts in vitro and in vivo.HOXB-AS3is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism,HOXB-AS3regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context ofNPM1mutations,HOXB-AS3overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts.
LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription
Authors: Yari Hamed , Jin Lei , Teng Liu , Wang Yufang , Wu Yongyan , Liu Guang Zhi , Gao Wei , Liang Jin , Xi Yanfeng , Feng Yu Chen , Zhang Chunming , Zhang Yuan Yuan , Tabatabaee Hessam , La Ting , Yang Rui Hong , Wang Fu Hua , Yan Xu Guang , Farrelly Margaret , Scott Rodney , Liu Tao , Thorne Rick F. , Guo Su Tang , Zhang Xu Dong 
Published: November 2019

AbstractProtein products of the regenerating islet-derived (REG) gene family are important regulators of many cellular processes. Here we functionally characterise a non-protein coding product of the family, the long noncoding RNA (lncRNA) REG1CP that is transcribed from a DNA fragment at the family locus previously thought to be a pseudogene. REG1CP forms an RNA–DNA triplex with a homopurine stretch at the distal promoter of the REG3A gene, through which the DNA helicase FANCJ is tethered to the core promoter of REG3A where it unwinds double stranded DNA and facilitates a permissive state for glucocorticoid receptor α (GRα)-mediated REG3A transcription. As such, REG1CP promotes cancer cell proliferation and tumorigenicity and its upregulation is associated with poor outcome of patients. REG1CP is also transcriptionally inducible by GRα, indicative of feedforward regulation. These results reveal the function and regulation of REG1CP and suggest that REG1CP may constitute a target for cancer treatment.
m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Authors: Mao Yuanhui , Dong Leiming , Liu Xiao-Min , Guo Jiayin , Ma Honghui , Shen Bin , Qian Shu-Bing 
Published: November 2019

AbstractDynamic mRNA modification in the form of N6-methyladenosine (m6A) adds considerable richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed along mature mRNAs, with approximately 35% of m6A residues located within the coding region (CDS). It has been suggested that methylation in CDS slows down translation elongation. However, neither the decoding feature of endogenous mRNAs nor the physiological significance of CDS m6A has been clearly defined. Here, we found that CDS m6A leads to ribosome pausing in a codon-specific manner. Unexpectedly, removing CDS m6A from these transcripts results in a further decrease of translation. A systemic analysis of RNA structural datasets revealed that CDS m6A positively regulates translation by resolving mRNA secondary structures. We further demonstrate that the elongation-promoting effect of CDS methylation requires the RNA helicase-containing m6A reader YTHDC2. Our findings established the physiological significance of CDS methylation and uncovered non-overlapping function of m6A reader proteins.
Global scenarios for significant water use
reduction in thermal power plants based on cooling water demand
estimation using satellite imagery
Authors: Lohrmann Alena , Farfan Javier , Caldera Upeksha , Lohrmann Christoph , Breyer Christian 
Published: November 2019

AbstractConnecting research on the water demand of power plants
with mitigation strategies for energy-based water use is an
important step to ensure global water and energy security, and thus
provide more sustainable use of both. Here, we assess the water
footprint of 13,863 thermal power plants units with a total active
capacity of 4,182 GW worldwide and give an estimate of the current
water demand for power production at four different levels—global,
regional, country and river. Furthermore, we provide a projection
for the energy transition period towards a net zero greenhouse gas
emissions economy by 2050. In particular, we show that by following
a ‘Best Policies Scenario’ the water consumption of global power
plants can be decreased by about 98%, and water withdrawal by 95% by
2050. Therefore, the suggested pathway provides one potential
solution to the problem of water depletion that results from the
water-energy nexus.
Complete genome sequence of Sphingomonas paucimobilis AIMST S2, a xenobiotic-degrading bacterium
Authors: Ravintheran Suganniiya K. , Sivaprakasam Sumitra , Loke Stella , Lee Su Yin , Manickam Ravichandran , Yahya Adibah , Croft Lawrence , Millard Andrew , Parimannan Sivachandran , Rajandas Heera 
Published: November 2019

AbstractComplete genomes of xenobiotic-degrading microorganisms provide valuable resources for researchers to understand molecular mechanisms involved in bioremediation. Despite the well-known ability of Sphingomonas paucimobilis to degrade persistent xenobiotic compounds, a complete genome sequencing is lacking for this organism. In line with this, we report the first complete genome sequence of Sphingomonas paucimobilis (strain AIMST S2), an organophosphate and hydrocarbon-degrading bacterium isolated from oil-polluted soil at Kedah, Malaysia. The genome was derived from a hybrid assembly of short and long reads generated by Illumina HiSeq and MinION, respectively. The assembly resulted in a single contig of 4,005,505 bases which consisted of 3,612 CDS and 56 tRNAs. An array of genes involved in xenobiotic degradation and plant-growth promoters were identified, suggesting its’ potential role as an effective microorganism in bioremediation and agriculture. Having reported the first complete genome of the species, this study will serve as a stepping stone for comparative genome analysis of Sphingomonas strains and other xenobiotic-degrading microorganisms as well as gene expression studies in organophosphate biodegradation.
A chromosome-level genome assembly of the Chinese tupelo Nyssa sinensis
Authors: Yang Xuchen , Kang Minghui , Yang Yanting , Xiong Haifeng , Wang Mingcheng , Zhang Zhiyang , Wang Zefu , Wu Haolin , Ma Tao , Liu Jianquan , Xi Zhenxiang 
Published: November 2019

AbstractThe deciduous Chinese tupelo (Nyssa sinensis Oliv.) is a popular ornamental tree for the spectacular autumn leaf color. Here, using single-molecule sequencing and chromosome conformation capture data, we report a high-quality, chromosome-level genome assembly of N. sinensis. PacBio long reads were de novo assembled into 647 polished contigs with a total length of 1,001.42 megabases (Mb) and an N50 size of 3.62 Mb, which is in line with genome sizes estimated using flow cytometry and the k-mer analysis. These contigs were further clustered and ordered into 22 pseudo-chromosomes based on Hi-C data, matching the chromosome counts in Nyssa obtained from previous cytological studies. In addition, a total of 664.91 Mb of repetitive elements were identified and a total of 37,884 protein-coding genes were predicted in the genome of N. sinensis. All data were deposited in publicly available repositories, and should be a valuable resource for genomics, evolution, and conservation biology.
Global map and indicators of food system sustainability
Authors: Béné Christophe , Prager Steven D. , Achicanoy Harold A. E. , Toro Patricia Alvarez , Lamotte Lea , Bonilla Camila , Mapes Brendan R. 
Published: November 2019

AbstractThis paper presents the first global map of food systems sustainability based on a rigorous protocol. The choice of the metric dimensions, as well as the individual indicators included in the metric, were initially identified from a thorough review of the existing literature. A rigorous inclusion/exclusion protocol was then used to refine the list and shorten it to a sub-set of 27 indicators. An aggregate sustainability score was then computed based on those 27 indicators organized into four dimensions: environment, social, food security & nutrition and economic. The paper shows how the availability of data (or lack therefore) results in an unavoidable trade-off between number of indicators and number of countries, and highlights how optimization can be used to present the most robust metric possible given the existence of this trade-offs in the data space. The process results in the computation of a global sustainability map covering 97 countries and 20 indicators. The sustainability scores obtained for each country are made available over the entire range of indicators.