bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contact tracing apps: an ethical roadmap
Authors: Lanzing Marjolein 
Published: September 2020

AbstractThis research statement presents a roadmap for the ethical evaluation of contact tracing apps. Assuming the possible development of an effective and secure contact tracing app, this roadmap explores three ethical concerns—privacy, data monopolists and coercion- based on three scenarios. The first scenario envisions and critically evaluates an app that is built on the conceptualization of privacy as anonymity and a mere individual right rather than a social value. The second scenario sketches and critically discusses an app that adequately addresses privacy concerns but is facilitated by data monopolists such as Google and Apple. The final scenario discusses the coerced installation and use of a privacy-friendly, independently developed contact tracing app. The main worry is coercion through societal exclusion and limited societal participation. The statement concludes with three suggestions for designing an ethical contact tracing app and a research agenda.
Adult literacy classes in Timor-Leste and diverse language values and practices across the regions: implications for language policy-making
Authors: Boon Danielle , da Conceição Savio Edegar , Kroon Sjaak , Kurvers Jeanne 
Published: September 2020

AbstractThis article draws on two studies of language diversity and adult literacy education in Timor-Leste that were conducted in different regions of the country between 2009 and 2013. Its central focus is on the day-to-day language practices and language values of local participants and the way in which these practices and values relate to national language policies. We first outline the views of language and of language policy-making that underpin our article. We then provide a brief overview of language-in-education policy-making in Timor-Leste with respect to provision for adult literacy. After that, we describe the design and conduct of the two studies and we present selected findings, drawing on both quantitative and qualitative data sources. The quantitative data were generated by means of questionnaire-based interviews and the research participants’ own accounts of their language repertoires, practices and values. The qualitative data were gathered via: (1) observation of adult literacy classes; (2) analysis of photographs of signage in local linguistic landscapes. We conclude with a discussion of the implications of our findings for language-in-education policy development in the area of adult literacy provision in countries in the global south, such as Timor-Leste. Here we plead for a greater involvement of teachers and learners as actors, not mere bystanders, who can bring new voices into policy-making processes and into research into these processes.
Developing dimensions for a new preference-based quality of life instrument for older people receiving aged care services in the community
Authors: Cleland Jenny , Hutchinson Claire , McBain Candice , Walker Ruth , Milte Rachel , Khadka Jyoti , Ratcliffe Julie 
Published: September 2020

Abstract
Purpose
To identify the salient quality of life characteristics relevant to older people in receipt of community aged care services in order to develop dimensions for a draft descriptive system for a new preference-based quality of life instrument.

Methods
Forty-one in-depth semi-structured interviews were undertaken with older people (65 years and over) receiving community aged care services across three Australian states to explore quality of life characteristics of importance to them. The data were analysed using framework analysis to extract broader themes which were organised into a conceptual framework. The data were then summarised into a thematic chart to develop a framework matrix which was used to interpret and synthesise the data. Care was taken throughout to retain the language that older people had adopted during the interviews to ensure that appropriate language was used when identifying and developing the quality of life dimensions.

Results
The analysis resulted in the identification of five salient quality of life dimensions: independence, social connections, emotional well-being, mobility, and activities.

Conclusion
This research finds that quality of life for older people accessing aged care services goes beyond health-related quality of life and incorporates broader aspects that transcend health. The findings represent the first stage in a multiphase project working in partnership with older people to develop a new preference-based instrument of quality of life for informing quality assessment and economic evaluation in community aged care. In future work, draft items will be developed from these dimensions and tested in face validity interviews before progressing to further psychometric testing.
Death is common, so is understanding it: the concept of death in other species
Authors: Monsó Susana , Osuna-Mascaró Antonio J. 
Published: September 2020

AbstractComparative thanatologists study the responses to the dead and the dying in nonhuman animals. Despite the wide variety of thanatological behaviours that have been documented in several different species, comparative thanatologists assume that the concept of death (CoD) is very difficult to acquire and will be a rare cognitive feat once we move past the human species. In this paper, we argue that this assumption is based on two forms of anthropocentrism: (1) an intellectual anthropocentrism, which leads to an over-intellectualisation of the CoD, and (2) an emotional anthropocentrism, which yields an excessive focus on grief as a reaction to death. Contrary to what these two forms of anthropocentrism suggest, we argue that the CoD requires relatively little cognitive complexity and that it can emerge independently from mourning behaviour. Moreover, if we turn towards the natural world, we can see that the minimal cognitive requirements for a CoD are in fact met by many nonhuman species and there are multiple learning pathways and opportunities for animals in the wild to develop a CoD. This allows us to conclude that the CoD will be relatively easy to acquire and, so, we can expect it to be fairly common in nature.
Ochratoxin A affects oocyte maturation and subsequent embryo developmental dynamics in the juvenile sheep model
Authors: Dell’Aquila Maria Elena , Asif Shafaq , Temerario Letizia , Mastrorocco Antonella , Marzano Giuseppina , Martino Nicola Antonio , Lacalandra Giovanni Michele , Roelen Bernard AJ , Carluccio Augusto , Robbe Domenico , Minervini Fiorenza 
Published: September 2020

AbstractThe genotoxic and nephrotoxic mycotoxin Ochratoxin A (OTA) has also been reported to have adverse effects on oocyte maturation and embryo development. Previous studies on the effects of OTA on female fertility have used micromolar concentrations, but no information is available to date on effects in a more relevant nanomolar range. This study used a juvenile sheep model to evaluate the effects of oocyte exposure to low levels of OTA on maturation, fertilization, and embryo development. Further, it was investigated whether different mechanisms of action of OTA could be responsible for varying toxic effects at different levels of exposure. Cumulus-oocyte-complexes (COCs) were exposed to 10 μmol/L–0.1 nmol/L OTA during in vitro maturation and evaluated for cumulus viability, oocyte maturation, and bioenergetic/oxidative status. COCs were subjected to in vitro fertilization, embryo culture, and embryo quality assessment via morphology, viability, bioenergetic/oxidative status, and time-lapse monitoring. At micromolar concentrations, OTA induced cytotoxic effects, by reducing cumulus expansion and oocyte maturation. OTA altered temporospatial dynamics of zygote pronuclear formation and embryo morphokinetics. Blastocysts, even morphologically normal, were found to undergo collapse events, which were probably related to boosted blastocyst mitochondrial activity. At nanomolar concentrations, OTA did not affect COC morpho-functional parameters, but impaired oocyte ability to prevent polyspermy and increased blastocyst apoptosis. In conclusion, in the female germ cell, cytotoxic nonspecific effects characterize OTA-induced toxicity at high exposure levels, whereas fine tuning-mode effects, not associated with altered cell viability and integrity, characterize OTA toxic action at low levels.
Distribution of T-2 toxin and HT-2 toxin during experimental feeding of yellow mealworm (Tenebrio molitor)
Authors: Piacenza Nicolo , Kaltner Florian , Maul Ronald , Gareis Manfred , Schwaiger Karin , Gottschalk Christoph 
Published: September 2020

AbstractWithin the European Union (EU), edible insects need to be approved as “Novel Food” according to Regulation (EU) 2015/2283 and must comply with the requirements of European food law with regard to microbiological and chemical food safety. Substrates used for feeding insects are susceptible to the growth of Fusarium spp. and consequently to contamination with trichothecene mycotoxins. Therefore, the current study aimed to investigate the influence of T-2 and HT-2 toxins on the larval life cycle of yellow mealworm (Tenebrio molitor (L.)) and to study the transfer of T-2, HT-2, T-2 triol and T-2 tetraol in the larvae. In a 4-week feeding study, T. molitor larvae were kept either on naturally (oat flakes moulded with Fusarium sporotrichioides) or artificially contaminated oat flakes, each at two levels (approximately 100 and 250 μg/kg total T-2 and HT-2). Weight gain and survival rates were monitored, and mycotoxins in the feeding substrates, larvae and residues were determined using LC-MS/MS. Larval development varied between the diets and was 44% higher for larvae fed artificially contaminated diets. However, the artificially contaminated diets had a 16% lower survival rate. No trichothecenes were detected in the surviving larvae after harvest, but T-2 and HT-2 were found both in the dead larvae and in the residues of naturally and artificially contaminated diets.
Hausbesuche im Kindes- und Erwachsenenschutz in der Schweiz – eine qualitative Studie
Authors: Koch Martina , Steffen Markus , Bühler Rahel 
Published: September 2020

ZusammenfassungIn dieser Forschungsnotiz wird ein laufendes Forschungsprojekt vorgestellt, das Hausbesuche im Kindes- und Erwachsenenschutz in verschiedenen Regionen der deutschsprachigen Schweiz untersucht. Für zwei Zeiträume (1960 bis 1980; 2000 bis 2020) wird rekonstruiert, aufgrund welcher fachlichen Überlegungen Hausbesuche bei Abklärungen von Gefährdungen im Kindes- und Erwachsenenschutz in Auftrag gegeben wurden/werden, wie sie abliefen/ablaufen, welches Wissen dabei produziert wurde/wird und wie dieses Wissen anschliessend prozessiert und entscheidungsrelevant gemacht wurde/wird. Die Untersuchung basiert auf einer qualitativen Analyse von Personenakten sowie auf einer Interviewstudie mit Fachkräften und von behördlichen Hausbesuchen betroffenen Menschen. Weiter werden teilnehmende Beobachtungen von Hausbesuchen durchgeführt.
Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study
Authors: Mohammed Soheir A. , Abdelhamed Amr , El Sayed Reda M. 
Published: September 2020

Abstract

Introduction
Most studies investigate sexual dysfunction in drug abusers; however, there are no data available about the pattern of drug abuse in patients with lifelong premature ejaculation (PE).

Aim
To assess the pattern of drug abuse in patients with lifelong PE and to evaluate its potential effect on their hormonal profile.

Methods
A cross-sectional study included patients with lifelong PE (n = 76) with no prescribed medications for 1 month and age-matched control without PE (n = 48). Participants were evaluated by history, examination, Arabic index of PE, and hormonal profile. A urine sample was screened by dipstick kits for the following drug abuse tramadol, opiate, tetrahydrocannabinol (cannabis), amphetamine, barbiturate, cocaine, and benzodiazepines. Positive results were confirmed with a immunoassay drug analyzer.

Main outcome measures
The outcomes of this study are positive and negative drug abuse and hormonal profile changes.

Results
Control patients and patients with PE showed median (interquartile range) of age 43 (33–46.8) and 38.5 (31–45) years, respectively. Drug abuse testing results showed significantly high positive drug abuse in patients with PE, 26 of 76 (34.2%), in comparison with control, 9 of 48 (19.1%) (P = .05). The most commonly abused drug was tetrahydrocannabinol in control, 3 of 9 (33.3%), and tramadol, 12 of 26 (46.2%), in patients with PE. Control patients and patients with PE with positive drug abuse had significantly higher smoking percent (P &lt; .0001) and higher positive drug abuse history (P &lt; .0001). However, there was no relationship between drug abuse and PE severity, and there were no significant changes in their hormonal profile.

Conclusions
Drug abuse is high among patients with lifelong PE in Upper Egypt, with tramadol being the comment drug. Drug abuse is common among smokers. However, no hormonal disturbance could be shown in drug abuse patients. Drug abuse might be considered in the evaluation of patients with PE.
Mohammed SA, Abdelhamed A, El Sayed RM. Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study. Sex Med 2020;8:608–614.
Older women using women's magazines: the construction of knowledgeable selves
Authors: Sawchuk Dana , Ly Mina 
Published: September 2020

AbstractWomen's magazines are widely read in Canada. The popularity of such magazines is significant because critical gerontologists, primarily drawing on content analyses of the magazines, often argue that these publications convey problematic messages about ageing. This article broaches the subject of women's magazines and ageing from a different vantage point, that of the older woman reader herself. This audience-centred research draws on 21 semi-structured interviews with Canadian women over the age of 55. The study examines what older women say about the ageing-related content of women's magazines, along with what they say about how, when and why they read these magazines. Findings illustrate that participants are aware of the inadequate and unrealistic representations of older women in women's magazines. Nonetheless, they value the publications as a source of practical information on a variety of topics and as a light and undemanding source of entertainment and relaxation. The study reveals how participants assess and deploy magazine contents and characteristics in ways that contribute to, and are informed by, their lives and identities as older women. Against the broader cultural context of ageism, using and talking about women's magazines enables the participants to position themselves as knowledgeable and informed on a variety of topics and in multiple interactions, both in explicit reference to the magazines themselves and more generally in their lives.
A Persistent Deep Anticyclonic Vortex in the Rockall Trough Sustained by Anticyclonic Vortices Shed From the Slope Current and Wintertime Convection
Authors: Smilenova Angelina , Gula Jonathan , Le Corre Mathieu , Houpert Loïc , Reecht Yves 
Published: September 2020

AbstractThe presence of a persistent surface anticyclone centered at approximately 55°N, 12°W in the Rockall Trough, northeast North Atlantic, has been previously noted in satellite altimetry data. Here, we show that this surface anticyclone is the imprint of a deep, persistent, non‐stationary anticyclonic vortex. Using wintertime 2007 and 2011 ship‐board data, we describe the anticyclone's vertical structure for the first time and find that the anticyclone core is partly made of warm and salty Mediterranean Overflow Water. The anticyclone has a radius of ~40 km, it stretches down to 2,000 m, with a velocity maximum around 500 m. To analyze the anticyclone's generating mechanism, we use a mesoscale‐resolving (~2 km) simulation, which produces a realistic pattern of the Rockall Trough anticyclone. The simulation indicates that the anticyclone is locally formed and sustained by two types of processes: wintertime convection and merger with anticyclonic vortices shed from the slope current flowing poleward along the eastern Rockall Trough slope. Intense negative vorticity filaments are generated along the Rockall Trough south‐eastern slope, and they encapsulate Mediterranean Overflow Water as they detach and grow into anticyclonic vortices. These Mediterranean Overflow Water‐rich vortices are advected into the trough, consequently merging with the Rockall Trough anticyclone and sustaining it. We suggest that the Rockall Trough anticyclone impacts regional intermediate water masses modifications, heat and salt budgets locally, and further afield into the neighboring subpolar northeast North Atlantic.
Strong Inland Propagation of Low‐Frequency Long Waves in River Estuaries
Authors: Guo Leicheng , Zhu Chunyan , Wu Xuefeng , Wan Yuanyang , Jay David A. , Townend Ian , Wang Zheng Bing , He Qing 
Published: September 2020

AbstractTidal waves traveling into estuaries are modified by channel geometry and river flow. The damping effect of river flow on incident astronomical tides is well documented, whereas its impact on low‐frequency tides like MSf and Mm is poorly understood. In this contribution, we employ a numerical model to explore low‐frequency tidal behavior under varying river flow. MSf and Mm are locally generated by frictional mechanisms inside an estuary, and they are larger in amplitude far upstream in tidal rivers and persist landward of the point of tidal extinction. Increasing river flow nonlinearly modulates the longitudinal variations of MSf and Mm amplitudes. This is dynamically explained by flow‐enhanced asymmetry in subtidal friction over the spring‐neap (MSf) and perigee‐apogee (Mm) cycles, respectively. Estuaries act as frequency filters, where low‐frequency waves decay at a smaller rate and propagate more inland than high‐frequency waves. Strong inland penetration of low‐frequency tides informs compound flood management.
The Effects of Upper‐Hybrid Waves on Energy Dissipation in the Electron Diffusion Region
Authors: Dokgo Kyunghwan , Hwang Kyoung‐Joo , Burch James L. , Yoon Peter H. , Graham Daniel B. , Li Wenya 
Published: September 2020

AbstractUsing a two‐dimensional particle‐in‐cell simulation, we investigate the effects and roles of upper‐hybrid waves (UHW) near the electron diffusion region (EDR). The energy dissipation via the wave‐particle interaction in our simulation agrees with J · E′ measured by magnetospheric multiscale (MMS) spacecraft. It means that UHW contributes to the local energy dissipation. As a result of wave‐particle interactions, plasma parameters which determine the larger‐scale energy dissipation in the EDR are changed. The y‐directional current decreases while the pressure tensor Pyz increases/decreases when the agyrotropic beam density is low/high, where (x, y, z)‐coordinates correspond the (L, M, N)‐boundary coordinates. Because the reconnection electric field comes from −∂Pyz/∂z, our result implies that UHW plays an additional role in affecting larger‐scale energy dissipation in the EDR by changing plasma parameters. We provide a simple diagram that shows how the UHW activities change the profiles of plasma parameters near the EDR comparing cases with and without UHW.
Shift Toward Intense and Widespread Precipitation Events Over the United States by Mid‐21st Century
Authors: Rastogi Deeksha , Touma Danielle , Evans Katherine J. , Ashfaq Moetasim 
Published: September 2020

AbstractThe United States has witnessed an increase in the frequency of intense and spatially widespread precipitation events in recent decades. Using a high‐resolution hybrid ensemble of regional climate simulations, we project further intensification of widespread extremes in the near future. The simulations cover 1966–2005 in the historical period and 2011–2050 in the future period under RCP8.5 scenario and show good correspondence with the observations in the historical period. The projected changes in the characteristics of precipitation events are associated with more frequent occurrence of extreme years where contribution from intense and widespread events to the annual precipitation is unprecedently high. While our findings are consistent with recent trends in the observations, they are in contrast to some earlier studies that project shrinking of precipitation events in the future period, which highlight the need for more rigorous investigations of changes in the spatial extent of precipitation in future climates.
Two-in-one strategy: a remineralizing and anti-adhesive coating against demineralized enamel
Authors: Hou Ailin , Luo Jun , Zhang Min , Li Jianshu , Chu Wenlin , Liang Kunneng , Yang Jiaojiao , Li Jiyao 
Published: September 2020

AbstractTooth enamel is prone to be attacked by injurious factors, leading to a de/remineralization imbalance. To repair demineralized enamel and prevent pulp inflammation caused by biofilm accumulation, measures are needed to promote remineralization and inhibit bacterial adhesion on the tooth surface. An innovative material, poly (aspartic acid)-polyethylene glycol (PASP-PEG), was designed and synthesized to construct a mineralizing and anti-adhesive surface that could be applied to repair demineralized enamel. A cytotoxicity assay revealed the low cytotoxicity of synthesized PASP-PEG. Adsorption results demonstrated that PASP-PEG possesses a high binding affinity to the hydroxyapatite (HA)/tooth surface. In vitro experiments and scanning electron microscopy (SEM) demonstrated a strong capacity of PASP-PEG to induce in situ remineralization and direct the oriented growth of apatite nanocrystals. Energy dispersive X-ray spectroscopy (EDS), X-ray diffraction analysis (XRD) and Vickers hardness tests demonstrated that minerals induced by PASP-PEG were consistent with healthy enamel in Ca/P ratio, crystal form and surface micro-hardness. Contact angle tests and bacterial adhesion experiments demonstrated that PASP-PEG yielded a strong anti-adhesive effect. In summary, PASP-PEG could achieve dual effects for enamel repair and anti-adhesion of bacteria, thereby widening its application in enamel repair.
TRIM29 inhibits miR-873-5P biogenesis via CYTOR to upregulate fibronectin 1 and promotes invasion of papillary thyroid cancer cells
Authors: Wu Tong , Zhang Da-Lin , Wang Jia-Mei , Jiang Jing-Yi , Du Xin , Zeng Xiao-Yan , Du Zhen-Xian 
Published: September 2020

AbstractPapillary thyroid cancer (PTC) is the most common endocrine tumor with an increasing incidence, has a strong propensity for neck lymph node metastasis. Limited treatment options are available for patients with advanced or recurrent metastatic disease, resulting in a poor prognosis. Tripartite motif protein 29 (TRIM29) is dysregulated in various cancer and functions as oncogene or tumor suppressor in discrete cancers. In this study, we found that both TRIM29 and fibronectin 1 (FN1) were upregulated with positive correlation in PTC tissues. Neither overexpression nor downregulation of TRIM29 altered the proliferation of PTC cells significantly. Overexpression of TRIM29 significantly promotes, while knockdown of TRIM29 significantly decreases migration and invasion by regulating FN1 expression in PTC cells. In terms of mechanism, we found that TRIM29 altered the stability of FN1 mRNA via regulation of miR-873-5p expression. The current study also demonstrated that long non-coding RNA (LncRNA) CYTOR suppressed maturation of miR-873-5p via interaction with premiR-873, and TRIM29 decreased miR-873-5p via upregulation of CYTOR. This study suggests that involvement of TRIM29 in migration and invasion in PTC cells may reveal potential metastatic mechanism of PTC and represent a novel therapeutic target and strategy.