bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paternal diet impairs F1 and F2 offspring vascular function through sperm and seminal plasma specific mechanisms in mice
Authors: Morgan Hannah L. , Paganopoulou Panaigota , Akhtar Sofia , Urquhart Natalie , Philomin Ranmini , Dickinson Yasmin , Watkins Adam J. 
Published: October 2019

Key points
A low protein diet had minimal effects on paternal cardiovascular function or renin–angiotensin system activity.
Paternal low protein diet modified F1 neonatal and adult offspring renin–angiotensin system activity and cardiovascular function in a sperm and/or seminal plasma specific manner.
Paternal low protein diet modified F1 male offspring testicular expression of central epigenetic regulators.
Significant changes in F2 neonatal offspring growth and tissue angiotensin‐converting enzyme activity were programmed by paternal low protein diet in a sperm and/or seminal plasma specific manner.
AbstractAlthough the impact of maternal diet on adult offspring health is well characterized, the role that a father's diet has on his offspring's health remains poorly defined. We establish the significance of a sup‐optimal paternal low protein diet for offspring vascular homeostasis and define the sperm and seminal plasma specific programming effects on cardiovascular health. Male C57BL6 mice were fed either a control normal protein diet (NPD; 18% protein) or an isocaloric low protein diet (LPD; 9% protein) for a minimum of 7 weeks. Using artificial insemination, in combination with vasectomized male mating, we generated offspring derived from either NPD or LPD sperm (devoid of seminal plasma) but in the presence of NPD or LPD seminal plasma (devoid of sperm). We observed that either LPD sperm or seminal fluid at conception impaired adult offspring vascular function in response to both vasoconstrictors and dilators. Underlying these changes in vascular function were significant changes in serum, lung and kidney angiotensin‐converting enzyme (ACE) activity, established in F1 offspring from 3 weeks of age, maintained into adulthood and present also within juvenile F2 offspring. Furthermore, we observed differential expression of multiple central renin–angiotensin system regulators in adult offspring kidneys. Finally, paternal diet modified the expression profiles of central epigenetic regulators of DNA methylation, histone modifications and RNA methylation in adult F1 male testes. These novel data reveal the impact of sub‐optimal paternal nutrition on offspring cardiovascular well‐being, programming offspring cardiovascular function through both sperm and seminal plasma specific mechanisms over successive generations.
Partitioned Coupling for Structural Acoustics
Authors: Bunting Gregory , Miller Scott T. 
Published: October 2019

Abstract
We expand the second-order fluid–structure coupling scheme of Farhat et al. (1998, “Load and Motion Transfer Algorithms for 19 Fluid/Structure Interaction Problems With Non-Matching Discrete Interfaces: Momentum and Energy Conservation, Optimal Discretization and Application to Aeroelasticity,” Comput. Methods Appl. Mech. Eng., 157(1–2), pp. 95–114; 2006, “Provably Second-Order Time-Accurate Loosely-Coupled Solution Algorithms for Transient Nonlinear Computational Aeroelasticity,” Comput. Methods Appl. Mech. Eng., 195(17), pp. 1973–2001) to structural acoustics. The staggered structural acoustics solution method is demonstrated to be second-order accurate in time, and numerical results are compared to a monolithically coupled system. The partitioned coupling method is implemented in the Sierra Mechanics software suite, allowing for the loose coupling of time domain acoustics in sierra/sd to structural dynamics (sierra/sd) or solid mechanics (sierra/sm). The coupling is demonstrated to work for nonconforming meshes. Results are verified for a one-dimensional piston, and the staggered and monolithic results are compared to an exact solution. Huang, H. (1969, “Transient Interaction of Plane Acoustic Waves With a Spherical Elastic Shell,” J. Acoust. Soc. Am., 45(3), pp. 661–670) sphere scattering problem with a spherically spreading acoustic load demonstrates parallel capability on a complex problem. Our numerical results compare well for a bronze plate submerged in water and sinusoidally excited (Fahnline and Shepherd, 2017, “Transient Finite Element/Equivalent Sources Using Direct Coupling and Treating the Acoustic Coupling Matrix as Sparse,” J. Acoust. Soc. Am., 142(2), pp. 1011–1024).
Organic carbon isotopes in terrestrial Permian-Triassic boundary sections of North China: Implications for global carbon cycle perturbations
Authors: Wu Yuyang , Tong Jinnan , Algeo Thomas J. , Chu Daoliang , Cui Ying , Song Huyue , Shu Wenchao , Du Yong 
Published: October 2019

Abstract
The end-Permian mass extinction (ca. 252 Ma) represents the most severe biotic crisis of the Phanerozoic, and it was accompanied by profound environmental perturbations, especially to the global carbon cycle, as indicated by sharp negative carbon isotope excursions (CIE) in both carbonates (δ13Ccarb) and organic matter (δ13Corg). To date, carbon isotope records are mostly from marine Permian-Triassic transitional sequences with relatively few high-resolution carbon isotope profiles having been generated for terrestrial facies. Terrestrial Permian-Triassic sequences suitable for high-resolution carbon isotope study are rare globally and are difficult to correlate with better-studied marine sequences. However, carbon isotope records from continental facies are essential to a full understanding of global carbon cycle changes during the Permian-Triassic transition. Here, we present bulk δ13Corg profiles for three terrestrial sections in North China representing Permian-Triassic transitional beds. These profiles exhibit similar patterns of secular variation defining three stages: (1) a pre-CIE interval, (2) a CIE interval, characterized by a rapid negative shift of 1.7‰–2.2‰ within the middle part of the Sunjiagou Formation, and (3) a post-CIE interval. The similarity of the CIE in all three study sections facilitates correlations among them, and its presence in the Permian-Triassic transitional beds suggests that it is equivalent to the negative CIE at the Permian-Triassic boundary in the Meishan global stratotype section and point (GSSP) and in coeval marine and terrestrial sections globally. The end-Permian CIE was probably triggered by a massive release of 13C-depleted carbon from volcanogenic sources leading to elevated atmospheric pCO2, although oceanic sources of CO2 cannot be ruled out at present.
Grand Canyon provenance for orthoquartzite clasts in the lower Miocene of coastal southern California
Authors: Sabbeth Leah , Wernicke Brian P. , Raub Timothy D. , Grover Jeffrey A. , Lander E. Bruce , Kirschvink Joseph L. 
Published: October 2019

AbstractOrthoquartzite detrital source regions in the Cordilleran interior yield clast populations with distinct spectra of paleomagnetic inclinations and detrital zircon ages that can be used to trace the provenance of gravels deposited along the western margin of the Cordilleran orogen. An inventory of characteristic remnant magnetizations (CRMs) from >700 sample cores from orthoquartzite source regions defines a low-inclination population of Neoproterozoic–Paleozoic age in the Mojave Desert–Death Valley region (and in correlative strata in Sonora, Mexico) and a moderate- to high-inclination population in the 1.1 Ga Shinumo Formation in eastern Grand Canyon. Detrital zircon ages can be used to distinguish Paleoproterozoic to mid-Mesoproterozoic (1.84–1.20 Ga) clasts derived from the central Arizona highlands region from clasts derived from younger sources that contain late Mesoproterozoic zircons (1.20–1.00 Ga). Characteristic paleomagnetic magnetizations were measured in 44 densely cemented orthoquartzite clasts, sampled from lower Miocene portions of the Sespe Formation in the Santa Monica and Santa Ana mountains and from a middle Eocene section in Simi Valley. Miocene Sespe clast inclinations define a bimodal population with modes near 15° and 45°. Eight samples from the steeper Miocene mode for which detrital zircon spectra were obtained all have spectra with peaks at 1.2, 1.4, and 1.7 Ga. One contains Paleozoic and Mesozoic peaks and is probably Jurassic. The remaining seven define a population of clasts with the distinctive combination of moderate to high inclination and a cosmopolitan age spectrum with abundant grains younger than 1.2 Ga. The moderate to high inclinations rule out a Mojave Desert–Death Valley or Sonoran region source population, and the cosmopolitan detrital zircon spectra rule out a central Arizona highlands source population. The Shinumo Formation, presently exposed only within a few hundred meters elevation of the bottom of eastern Grand Canyon, thus remains the only plausible, known source for the moderate- to high-inclination clast population. If so, then the Upper Granite Gorge of the eastern Grand Canyon had been eroded to within a few hundred meters of its current depth by early Miocene time (ca. 20 Ma). Such an unroofing event in the eastern Grand Canyon region is independently confirmed by (U-Th)/He thermochronology. Inclusion of the eastern Grand Canyon region in the Sespe drainage system is also independently supported by detrital zircon age spectra of Sespe sandstones. Collectively, these data define a mid-Tertiary, SW-flowing “Arizona River” drainage system between the rapidly eroding eastern Grand Canyon region and coastal California.
Physically active lessons in schools and their impact on physical activity, educational, health and cognition outcomes: a systematic review and meta-analysis
Authors: Norris Emma , van Steen Tommy , Direito Artur , Stamatakis Emmanuel 
Published: October 2019

ObjectiveThis review provides the first meta-analysis of the impact of physically active lessons on lesson-time and overall physical activity (PA), as well as health, cognition and educational outcomes.DesignSystematic review and meta-analysis of controlled studies. Six meta-analyses pooled effects on lesson-time PA, overall PA, in-class educational and overall educational outcomes, cognition and health outcomes. Meta-analyses were conducted using the metafor package in R. Risk of bias was assessed using the Cochrane tool for risk of bias.Data sourcesPubMed, Embase, PsycINFO, ERIC and Web of Science, grey literature and reference lists were searched in December 2017 and April 2019.Studies eligibility criteriaPhysically active lessons compared with a control group in a randomised or non-randomised design, within single component interventions in general school populations.Results42 studies (39 in preschool or elementary school settings, 27 randomised controlled trials) were eligible to be included in the systematic review and 37 of them were included across the six meta-analyses (n=12 663). Physically active lessons were found to produce large, significant increases in lesson-time PA (d=2.33; 95% CI 1.42 to 3.25:k=16) and small, increases on overall PA (d=0.32; 95% CI 0.18 to 0.46:k=8), large, improvement in lesson-time educational outcomes (d=0.81; 95% CI 0.47 to 1.14:k=7) and a small improvement in overall educational outcomes (d=0.36; 95% CI 0.09 to 0.63:k=25). No effects were seen on cognitive (k=3) or health outcomes (k=3). 25/42 studies had high risk of bias in at least two domains.ConclusionIn elementary and preschool settings, when physically active lessons were added into the curriculum they had positive impact on both physical activity and educational outcomes. These findings support policy initiatives encouraging the incorporation of physically active lessons into teaching in elementary and preschool setting.Trial registration numberCRD42017076933.
Drug-related community issues and the required interventions in open drug scenes in Tehran, Iran: a qualitative study protocol
Authors: Saberi Zafarghandi Mohammad Bagher , Eshrati Sahar , Vameghi Meroe , Ranjbar Hadi , Arezoomandan Reza , Clausen Thomas , Waal Helge 
Published: October 2019

Background and objectivesMany low-income and middle-income countries experience problems with open drug scenes and drug-related community issues (DRCIs). These experiences occur in settings with varying levels of health and law enforcement initiatives, and accordingly a range of approaches are implemented to curb the problem. Most of the published literature stems from Western and high-income societies. With this concern, the present study aims to describe a planned project to explore DRCIs in the open drug scenes of Tehran, including its typology, and predisposing and reinforcing factors. In addition, the study attempts to investigate the perceptions with respect to the required interventions and barriers to their accessibility.MethodsTo this end, the current study focuses on the Farahzad drug scene due to its structure and the difficult access to the scene by harm reduction providers. Data collection techniques encompass field observation, indepth interview and focus group discussion. Further, semistructured interviews are conducted with people who use drugs and other key informants who are engaged at this drug scene, including business, community, voluntary and statutory stakeholders, for an average of 90 min (average of 45 min for each part of the study). Furthermore, as a complementary method, field observation is performed regarding the themes of DRCIs at this scene. Then, focus group discussions are held to further describe the themes of DRCIs as well as to explore the required interventions, for an average of 90 min. Finally, the results are evaluated using qualitative content analysis.Ethics and disseminationEthical approval for the study was obtained from the Ethics Committee of Iran University of Medical Sciences, Iran. Additionally, participants are to provide written informed consent. The findings of the study are expected to play a role in promoting the current intervention.
Presentation and healthcare delays among people with tuberculosis in London, and the impact on treatment outcome
Authors: Evenden Poppy , Roche Anita , Karo Basel , Balasegaram Sooria , Anderson Charlotte S 
Published: October 2019

BackgroundA quarter of London’s pulmonary tuberculosis (TB) patients have over 4 months of delay. Late diagnosis increases disease severity and the risk of transmission. We aim to classify delays, identify associated risk factors and assess treatment outcome.MethodsWe conducted a retrospective cohort study using London surveillance data, 2012–2018 on adults aged ≥18 years with pulmonary TB. We defined presentation delay (days from symptom onset to first healthcare visit) and healthcare delay (first healthcare visit to treatment commencement) as dichotomous variables; positive delay being days equal or greater than the third quartile. We applied logistic regression models to identify risk factors associated with delays and treatment outcome at 12 months.ResultsOf 7216 people, 4539 reported presentation and 5193 healthcare delays. The third quartiles for presentation and healthcare delay were 84 and 61 days, respectively. Presentation delay was associated with female sex (adjusted OR (aOR)=1.21; 95% CI 1.04 to 1.39), increasing age (aOR=1.004; 95% CI 1.001 to 1.008), white compared to Asian ethnicity (aOR=1.35; 95% CI 1.12 to 1.62), previous imprisonment (aOR=1.66; 95% CI 1.22 to 2.26) and alcohol misuse (aOR=1.44; 95% CI 1.04 to 1.89). Healthcare delay was associated with female sex (aOR=1.39; 95% CI 1.21 to 1.59), increasing age (aOR=1.014; 95% CI 1.009 to 1.018) and white ethnicity (aOR=1.41; 95% CI 1.19 to 1.68). 16% of 5678 people with known outcome did not complete treatment. Neither delay was associated with non-completion (p value <0.05).ConclusionsFemale, white and older people with TB were more likely to experience both presentation and healthcare delays. Social risk factors were also associated with delay in presentation. Early diagnosis and treatment remain critical to reduce transmission, regardless of whether delay affected completion.
End-of-life care in intellectual disability: a retrospective cross-sectional study
Authors: Hunt Katherine , Bernal Jane , Worth Rhian , Shearn Julia , Jarvis Paul , Jones Edwin , Lowe Kathy , Madden Phil , Barr Owen , Forrester-Jones Rachel , Kroll Thilo , McCarron Mary , Read Sue , Todd Stuart 
Published: October 2019

BackgroundAdults with intellectual disability (ID) experience inequality in access to healthcare that is considered to extend to end-of-life care. Their experiences of healthcare at the end of life and how these compare with the general population are unknown.AimTo describe the end-of-life care outcomes for adults with ID living in residential care in the UK using the VOICES-SF questionnaire and compare these with the general population.DesignNationwide population-based postbereavement survey.Participants38 ID care providers took part in the study. The supported over 13 000 people with ID. Over the 18-month period of data collection, 222 deaths were reported. The survey was completed, by care staff, for 157 (70.7%) of those deaths.ResultsDecedents had complex health, functional and behavioural needs. Death was unanticipated in a high proportion of cases. Quality of care provided across care settings was generally well rated. However, hospital care and care provided at the time of was less well rated, particularly in comparison with the general population. Respondents reported low levels of involvement in care and awareness of approaching death among adults with ID, and lower than in the general population.ConclusionsAccess to end-of-life care for adults with ID may be constrained by a failure to identify approaching the end of life. The high proportion of unexpected deaths in this population warrants further study. There is a need to increase and support the involvement of adults with ID to be active partners in planning care at the end of their lives.
Forward–backward asymmetry in the gauge-Higgs unification at the International Linear Collider
Authors: Funatsu Shuichiro 
Published: October 2019

Abstract
The signals of the $$SO(5)\times U(1)$$SO(5)×U(1) gauge-Higgs unification model at the International Linear Collider are studied. In this model, Kaluza–Klein modes of the neutral gauge bosons affect fermion pair productions. The deviations of the forward–backward asymmetries of the $$e^+e^-\rightarrow \bar{b}b$$e+e-→b¯b, $$\bar{t}t$$t¯t processes from the standard model predictions are clearly seen by using polarised beams. The deviations of these values are predicted for two cases, the bulk mass parameters of quarks are positive and negative case.
Noise test method for dual-gate MOSFET device
Authors: Jia Xiaofei , Chen Wenhao , Ding Bing , He Liang 
Published: October 2019

In recent years, with the development of mesoscopic physics and nanoelectronics, the research on noise and testing technology of electronic components has been developed. It is well known that noise can characterize the transmission characteristics of carriers in nanoscale electronic components. With the continuous shrinking of the device size, the carrier transport of nanoscale MOSFET devices has been gradually transformed from the traditional drift-diffusion to become the quasi-ballistic or ballistic transport, and its current noise contains granular and thermal noise. The paper by Jeon et al. [The first observation of shot noise characteristics in 10-nm scale MOSFETs, in Proc. 2009 Symp. VLSI Technology (IEEE, Honolulu, 2009), pp. 48–49] presents the variation relation of 20 nm MOSFET current noise with source–drain current and voltage, and its current noise characteristic is between thermal noise and shot noise, so 20 nm MOSFET current noise is shot noise and thermal noise. The paper by Navid et al. [J. Appl. Phys. 101 (2007) 124501] shows through simulation that the 60 nm MOSFET current noise is suppressed shot noise and thermal noise. At present, the current noise has seriously affected the basic performance of the device, thus the circuit cannot work normally. Therefore, it is necessary to study the generation mechanism and characteristics of current noise in electronic components so as to suppress device noise, which can not only realize the reduction of device noise, but also play a positive role in the work-efficiency, life-span and reliability of electronic components.
Flexible organization of grip force control during movement frequency scaling
Authors: Grover Francis M. , Schwab Sarah M. , Silva Paula L. , Lorenz Tamara , Riley Michael A. 
Published: October 2019

The grip force applied to maintain grasp of a handheld object has been typically reported as tightly coupled to the load force exerted by the object as it is actively manipulated, occurring proportionally and consistently in phase with changes in load force. However, continuous grip force-load force coupling breaks down when overall load force levels and oscillation amplitudes are lower (Grover F, Lamb M, Bonnette S, Silva PL, Lorenz T, Riley MA. Exp Brain Res 236: 2531–2544, 2018) or more predictable (Grover FM, Nalepka P, Silva PL, Lorenz T, Riley MA. Exp Brain Res 237: 687–703, 2019). Under these circumstances, grip force is instead only intermittently coupled to load force; continuous coupling is prompted only when load force levels or variations become sufficiently high or unpredictable. The current study investigated the nature of the transition between continuous and intermittent modes of grip force control by scaling the load force level and the oscillation amplitude continuously in time by means of scaling the required frequency of movement oscillations. Participants grasped a cylindrical object between the thumb and forefinger and oscillated their arm about the shoulder in the sagittal plane. Oscillation frequencies were paced with a metronome that scaled through an ascending or descending frequency progression. Due to greater accelerations, faster frequencies produced greater overall load force levels and more pronounced load oscillations. We observed smooth but nonlinear transitions between clear regimes of intermittent and continuous grip force-load force coordination, for both scaling directions, indicating that grip force control can flexibly reorganize as parameters affecting grasp (e.g., variations in load force) change over time. NEW & NOTEWORTHY Grip force (GF) is synchronously coupled to changing load forces (LF) during object manipulation when LF levels are high or unpredictable, but only intermittently coupled to LF during less challenging grasp conditions. This study characterized the nature of transitions between synchronous and intermittent GF-LF coupling, revealing a smooth but nonlinear change in intermittent GF modulation in response to continuous scaling of LF amplitude. Intermittent, “drift-and-act” control may provide an alternative framework for understanding GF-LF coupling.