bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macaulay’s theory of duration: 80-year thematic bibliometric review of the literature
Authors: Shah Syed Alamdar Ali , Sukmana Raditya , Fianto Bayu Arie 
Published: April 2020

PurposeThe purpose of this research is to propose a framework for research on Macaulay duration and establish future research directions.Design/methodology/approachThematic, bibliometric and content analyses have been used to review 168 research papers published between 1938 and 2019 taken from ISI Web of Science and Scopus contributed by leading authors, journals and regulatory bodies.FindingsIdentification and integration of themes of duration theory, duration model development and duration model implementation leading to unattended research gaps, and framework for research on Macaulay duration.Research limitations/implicationsThe study is based on an extensive review of the literature to extract important themes, research gaps and frameworks. It does not empirically investigate significance of Macaulay duration and various sectors.Practical implicationsThis research has several aspects that are helpful for practitioners. Macaulay duration has been the subject of empirical research only without any guiding framework. This research provides a platform to initiate profound researches in various areas of finance. Various proposed models are required to be tested under holistic approach in conventional and emerging fields, especially in Islamic settings.Originality/valueThis research highlights, research themes leading to framework, research gaps and factors that are crucial in developing, extending and testing duration models leading to enhancement of theoretical base of Macaulay duration.
Photoacoustic effect and controlled release of azo and Schiff base derivatives modified by click reagents under the NIR light
Authors: Yang Libin , Wang Dong , Gao Hong , Cao Hui , Zhao Yuzhen , Miao Zongcheng , Yang Zhou , He Wanli 
Published: April 2020

Purpose
This study aims to develop a new kind of functional low molecular weight organic dyes, which is highly efficient, meanwhile inexpensive and easily prepared and modified and can be used in photoacoustic (PA) imaging and photothermal therapy (PTT). To further realize the release of molecules under the biomedical condition, the releasing efficiency of micellar nanoparticles under different stimuli were represented.

Design/methodology/approach
A class of azo and Schiff base derivatives with different click reagents were characterized by PA imaging and photothermal (PT) experiments. The molecule with best PT effect was loaded into a temperature-stimuli-sensitive amphiphilic block copolymer which demonstrated the capability of releasing the polymers under the near-infrared (NIR) light of 650 nm.

Findings
The PA and PT effects of a series of azo and Schiff base derivatives with different click reagents were characterized. Introducing the click reagent F4-TCNQ can result in red shift of peaks of PA intensity. Stimulated with 650 nm laser irradiation, the polymer processed higher release rate than being stimulated by temperature stimuli.

Practical implications
This paper not only guides the design of NIR dyes with good PA intensity but also provides a method which has great potential for the application of NIR photothermal dyes in the field of biotechnology for controlled release.

Originality/value
This paper uses click reagents to modify azo and Schiff derivatives and an amphiphilic block copolymer under NIR light to realize controlled release.
Sport tourism: a perspective article
Authors: Higham James 
Published: April 2020

Purpose
The purpose of this paper is to review the past 75 years of sports tourism and explore the potential of the next 75 years.

Design/methodology/approach
This is a personal perspective paper that reflects upon the emergence and development of the field of sport tourism, contemporary challenges and future pathways.

Findings
Research must extend to wider manifestations of sport, and sport-related tourism, in response to the growth of participation and pleasure sports and the increasingly important roles of those sports in addressing the growing social and environmental challenges of contemporary life.

Originality/value
This paper offers insights into the future of sports tourism.
Lung nuclear protein in testis carcinoma in an elderly Korean woman: A case report with cytohistological analysis
Authors: Cho Hwa Jin , Lee Hyun‐Kyung 
Published: April 2020

Nuclear protein in testis (NUT) carcinoma is a rare, aggressive carcinoma that is a diagnostic challenge for pathologists. Here, we report a case of NUT carcinoma in a 63‐year‐old woman with uncommon immunohistochemical results. The initial bronchoscopic biopsy revealed a poorly differentiated carcinoma with p63 immunohistochemical stain positivity. However, the cytomorphological features of the pleural fluid were unusual. Immunohistochemical staining of the pleural fluid revealed diffuse positivity for vimentin and focal positivity for cytokeratin and neuroendocrine markers. Because of chemoresistance, other malignancies, including sarcomatoid carcinoma, combined small cell carcinoma, and an unusual form of NUT carcinoma, were considered as differential diagnoses. The diagnosis of NUT carcinoma was confirmed using NUT‐specific antibodies and fluorescence in situ hybridization. The current case was a diagnostic challenge because of the poorly differentiated cytomorphology and uncommon immunohistochemical results. Pathologists and clinicians should consider NUT carcinoma in the differential diagnosis, as this malignancy has a dismal prognosis and needs to be diagnosed accurately for the most effective treatment.Key points
Metastatic NUT carcinoma can show diffuse vimentin positivity and focal neuroendocrine marker positivity. NUT carcinoma can be misdiagnosed as basaloid squamous cell carcinoma in routine diagnosis, especially in older‐aged patients.
This study was a diagnostic challenge because of the poorly differentiated cytomorphology and uncommon immunohistochemical results for NUT carcinoma. Pathologists should differentially diagnose NUT carcinoma when rare cytohistological features are observed at any age.
Causes of late mortality among ICU‐treated patients with sepsis
Authors: Wilhelms Susanne B. , Walther Sten M. , Sjöberg Folke , De Geer Lina 
Published: April 2020

BackgroundPatients with sepsis may have an increased risk of late mortality, but the causes of late death are unclear. This retrospective matched cohort study aimed to determine the causes of late death (≥1 year) among patients with sepsis compared to patients without sepsis.Methods8760 patients with severe sepsis or septic shock (2001 consensus criteria) registered in the Swedish Intensive Care Registry (2008‐2013) were compared with a 1:1 matched (gender, age, SAPS3 probability for death, ICU length of stay) control group consisting of non‐septic ICU patients. Causes of death (International Classification of Diseases codes) were obtained from the Swedish Cause of Death Register (2008‐2014).ResultsDuring 2008‐2014, 903 patients with sepsis died at ≥365 days after their initial septic event, compared to 884 patients in the control group. Median time of follow‐up was 313 days (sepsis group, interquartile range 11‐838 days) vs 288 days (control group, 9‐836 days). The most common causes of death were heart diseases (sepsis: 50.2%, non‐septic: 48.6%) and cancer (sepsis: 33.7%, non‐septic: 31.7%). Infectious diseases were significantly more common cause of death in the sepsis group (24.3% vs 19.6%, respectively; P < .05). Pneumonia was a common infectious cause of death in both groups, whereas sepsis was more common in the sepsis group.ConclusionsThe most common causes of late death after ICU admission among patients with and without sepsis were heart diseases and cancer. However, patients with sepsis more frequently had infectious diseases as a cause of late death, compared to non‐septic patients.
Cost‐effectiveness of a specialist smoking cessation package compared with standard smoking cessation services for people with severe mental illness in England: a trial‐based economic evaluation from the SCIMITAR+ study
Authors: Li Jinshuo , Fairhurst Caroline , Peckham Emily , Bailey Della , Arundel Catherine , Hewitt Catherine , Heron Paul , Crosland Suzanne , Parrott Steve , Gilbody Simon ,   SCIMITAR+ collaborative
Published: April 2020

AbstractAimsTo evaluate the cost‐effectiveness of a specialist smoking cessation package for people with severe mental illnessDesignIncremental cost‐effectiveness analysis was undertaken from the UK National Health Service and Personal Social Services perspective over a 12‐month time horizon. Total costs, including smoking cessation, health‐care and social services costs and quality‐adjusted life years (QALYs), derived from the five‐level EuroQol 5‐dimension (EQ‐5D‐5 L), collected from a randomized controlled trial, were used as outcome measures. The bootstrap technique was employed to assess the uncertainty.SettingSixteen primary care and 21 secondary care mental health sites in England.ParticipantsAdult smokers with bipolar affective disorder, schizoaffective disorder or schizophrenia and related illnesses (n = 526).Intervention and comparatorA bespoke smoking cessation (BSC) package for people with severe mental illness offered up to 12 individual sessions with a mental health smoking cessation practitioner versus usual care (UC). Of the participants who were randomized, 261 were in UC group and 265 were in BSC group.MeasurementsBSC intervention cost was estimated from the treatment log. Costs of UC, health‐care and social services and EQ‐5D‐5 L were collected at baseline, 6‐ and 12‐month follow‐ups. Incremental costs and incremental QLAYs were estimated using regression adjusting for respective baseline values and other baseline covariates.FindingsThe mean total cost in the BSC group was £270 [95% confidence interval (CI) = –£1690 to £1424] lower than in the UC group, while the mean QALYs were 0.013 (95% CI = –0.008 to 0.045) higher, leading to BSC dominating UC (76% probability of cost‐effective at £20 000/QALY).ConclusionsA bespoke smoking cessation package for people with severe mental illness is likely to be cost‐effective over 12 months compared with usual care provided by the UK's National Health Service and personal social services.
Type 2 immunity in the skin and lungs
Authors: Akdis Cezmi A. , Arkwright Peter D. , Brüggen Marie-Charlotte , Busse William , Gadina Massimo , Guttman‐Yassky Emma , Kabashima Kenji , Mitamura Yasutaka , Vian Laura , Wu Jianni , Palomares Oscar 
Published: April 2020

AbstractThere has been extensive progress in understanding the cellular and molecular mechanisms of inflammation and immune regulation in allergic diseases of the skin and lungs during the last few years. Asthma and atopic dermatitis (AD) are typical diseases of type 2 immune responses. interleukin (IL)‐25, IL‐33, and thymic stromal lymphopoietin are essential cytokines of epithelial cells that are activated by allergens, pollutants, viruses, bacteria, and toxins that derive type 2 responses. Th2 cells and innate lymphoid cells (ILC) produce and secrete type 2 cytokines such as IL‐4, IL‐5, IL‐9, and IL‐13. IL‐4 and IL‐13 activate B cells to class‐switch to IgE and also play a role in T‐cell and eosinophil migration to allergic inflammatory tissues. IL‐13 contributes to maturation, activation, nitric oxide production and differentiation of epithelia, production of mucus as well as smooth muscle contraction, and extracellular matrix generation. IL‐4 and IL‐13 open tight junction barrier and cause barrier leakiness in the skin and lungs. IL‐5 acts on activation, recruitment, and survival of eosinophils. IL‐9 contributes to general allergic phenotype by enhancing all of the aspects, such as IgE and eosinophilia. Type 2 ILC contribute to inflammation in AD and asthma by enhancing the activity of Th2 cells, eosinophils, and their cytokines. Currently, five biologics are licensed to suppress type 2 inflammation via IgE, IL‐5 and its receptor, and IL‐4 receptor alpha. Some patients with severe atopic disease have little evidence of type 2 hyperactivity and do not respond to biologics which target this pathway. Studies in responder and nonresponder patients demonstrate the complexity of these diseases. In addition, primary immune deficiency diseases related to T‐cell maturation, regulatory T‐cell development, and T‐cell signaling, such as Omenn syndrome, severe combined immune deficiencies, immunodysregulation, polyendocrinopathy, enteropathy, X‐linked syndrome, and DOCK8, STAT3, and CARD11 deficiencies, help in our understanding of the importance and redundancy of various type 2 immune components. The present review aims to highlight recent advances in type 2 immunity and discuss the cellular sources, targets, and roles of type 2 mechanisms in asthma and AD.
Fragmented QRS in prediction of ischemic heart disease diagnosed by stress cardiovascular magnetic resonance imaging
Authors: Yooprasert Pimpimol , Vathesatogkit Prin , Thirawuth Varinsawat , Prasertkulchai Watcharee , Tangcharoen Tarinee 
Published: April 2020

AbstractBackgroundIn patients with ischemic heart disease (IHD), many studies demonstrated an association between fragmented QRS complex (fQRS) on 12‐lead ECG and myocardial scar, heart failure, and increased mortality. However, data in adults without history of IHD is limited. We aimed to evaluate whether there is an association between fQRS and IHD diagnosed by stress cardiac MRI.MethodWe retrospectively reviewed demographic data, 12‐lead ECG, and stress cardiac MRI data from 604 patients. Fragmented QRS was defined as the presence of additional R wave (R’), notching in the nadir of R or S wave, or the presence of more than one R’ in any ECG leads. Both cardiac MRI and ECG were analyzed by two independent observers.ResultFinal analysis included 554 patients, 39% were male, with a mean age of 67.8 ± 11.1 years. There was positive stress cardiac MRI in 219 patients (39.5%). Older age, diabetes mellitus, and hypertension were more frequent in the positive group (p < .05). fQRS was identified in 300 patients (54.2%). Baseline characteristic did not differ significantly between patients with and without fQRS. There is an association between fQRS and IHD, OR 1.605 (95% CI 1.14–2.27), p = .007. After adjustment for age, diabetes, hypertension, renal function, and left ventricular ejection fraction, the strong association between fQRS and IHD persisted, OR 1.71 (95% CI 1.18–2.47), p = .004.ConclusionIn patients without known history of coronary artery disease, fragmented QRS is independently associated with ischemic heart disease diagnosed by stress cardiac MRI.
Cell investigation into the biocompatibility of adult human dermal fibroblasts with PCL nanofibers/TiO2 nanotubes on the surface of Ti–30Ta alloy for biomedical applications
Authors: Capellato Patrícia , Silva Gilbert , Popat Ketul , Simon‐Walker Rachael , Alves Claro Ana Paula , Zavaglia Cecilia 
Published: April 2020

AbstractThe polymer poly(ε‐caprolactone) (PCL) has been used in the biomaterial field for its relatively inexpensive price and suitability for modification. Also, its chemical and biological properties are desirable for biomedical applications. The electrospinning process has been used for producing polymer fibers of PCL due in large part to an increased interest in nanoscale properties and technologies. Moreover, the use of biocompatible polymers for the viability of cell growth is a promising alternative to improve osseointegration. Characterization techniques such as scanning electron microscopy and contact angle were used for analyses of samples. Adult human dermal fibroblasts (neonatal) were utilized to evaluate the biocompatibility of the association of the electrospinning process of the biocompatible polymer (PCL) with TiO2 nanotubes on the Ti–30Ta alloy surface. The results of this study showed a favorable response for adhesion on the surface. This promising material is due to the modulation of the biological response.
A Combined Health Action Process Approach and mHealth Intervention to Increase Non‐Sedentary Behaviours in Office‐Working Adults—A Randomised Controlled Trial
Authors: Rollo Scott , Prapavessis Harry 
Published: April 2020

BackgroundOffice‐working adults represent an at‐risk population for high levels of sedentary behaviour (SB), which has been associated with an increased risk for numerous chronic diseases. This study examined the effectiveness of a Health Action Process Approach (HAPA) based planning intervention augmented with tailored text messages to reduce workplace sitting time (primary outcome) and increase specific non‐SBs (i.e. standing time, walking time, stretching time, break frequency, break duration). A secondary purpose was to examine relationships among HAPA volitional constructs and sedentary and non‐SBs.MethodsFull‐time office workers (Mage = 45.18 ± 11.33 years) from Canada were randomised into either a HAPA intervention (n = 29) or control (n = 31) condition. Workplace sitting time, time spent in specific non‐SBs, and HAPA volitional constructs were assessed at baseline, weeks 2, 4, 6 (post‐intervention), and 8 (follow‐up).ResultsSignificant group by time interaction effects, that favoured the intervention group, were found for sitting time (p = .003, ɳp2 = .07), standing time (p = .019, ɳp2 = .05), and stretching time (p = .001, ɳp2 = .08) as well as for action planning (p < .001, ɳp2 = .20), coping planning (p < .001, ɳp2 = .18), and action control (p < .001, ɳp2 = .15). Significant correlations (p < .05) were also found between the HAPA constructs and time spent sitting, standing, walking, as well as break frequency.ConclusionsAugmenting a HAPA‐based planning intervention with text messages can reduce workplace sitting time in office workers.TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03461926.
The natural course of pregnancies in women with primary atypical haemolytic uraemic syndrome and asymptomatic relatives
Authors: Timmermans Sjoerd A. M. E. G. , Werion Alexis , Spaanderman Marc E. A. , Reutelingsperger Chris P. , Damoiseaux Jan G. M. C. , Morelle Johann , van Paassen Pieter 
Published: April 2020

SummaryPregnancy has been linked to various microangiopathies, including primary atypical haemolytic uraemic syndrome (aHUS). Complement dysregulation, often linked to rare variants in complement genes, is key for primary aHUS to manifest and may play a role in pregnancy complications of the mother and fetus. The burden of such complications is unknown, making counselling of women with primary aHUS and asymptomatic relatives difficult. We analyzed the maternal and fetal outcomes of 39 pregnancies from 17 women with primary aHUS and two asymptomatic relatives. Seven out of 39 pregnancies were complicated by pregnancy‐associated aHUS. Five out of 32 pregnancies not linked to pregnancy‐associated aHUS were complicated by pre‐eclampsia or HELLP. Rare genetic variants were identified in 10 women (asymptomatic relatives, n = 2) who had a total of 14 pregnancies, including 10 uncomplicated pregnancies. Thirty‐five out of 39 pregnancies resulted in live birth. Eight out of 19 women had progressed to end‐stage kidney disease, with an incidence of 2·95 (95% confidence interval, 1·37–5·61) per 100 person‐years after the first pregnancy. Thus, we emphasized the frequency of successful pregnancies in women with primary aHUS and asymptomatic relatives. Pregnancies should be monitored closely. Rare genetic variants cannot predict the risk of a given pregnancy.
Estimating a normal reference range for serum B‐cell maturation antigen levels for multiple myeloma patients
Authors: Jew Scott , Bujarski Sean , Soof Camilia , Chen Haiming , Safaie Tahmineh , Li Mingjie , Sanchez Eric , Wang Cathy , Emamy‐Sadr Marsiye , Swift Regina , Rahbari Ashkon , Patil Saurabh , Souther Eric , Spektor Tanya M. , Berenson James R. 
Published: April 2020

SummaryThe serum B‐cell maturation antigen (sBCMA) has been identified as a novel serum biomarker for patients with multiple myeloma. However, no study has yet established a reference range for sBCMA levels. Its levels were determined in 196 healthy subjects and showed a right‐tailed distribution with a median value of 37·51 ng/ml with a standard deviation of 22·54 ng/ml (range 18·78–180·39 ng/ml). Partitioning of subgroup reference ranges was considered but determined to be irrelevant. A non‐parametric method using the median ± 2 standard deviations suggests using a universal reference interval of <82·59 ng/ml.
Targeted and systematic cognitive freehand‐guided transperineal biopsy: is there still a role for systematic biopsy?
Authors: Neale Anoushka , Stroman Luke , Kum Francesca , Jabarkhyl Dost , Di Benedetto Antonina , Mehan Nicholas , Rusere Jonah , Chandra Ashish , Challacombe Ben , Cathcart Paul , Dasgupta Prokar , Elhage Oussama , Popert Rick 
Published: April 2020

ObjectivesTo assess whether targeted cognitive freehand‐assisted transperineal biopsies using a PrecisionpointTM device still require additional systematic biopsies to avoid missing clinically significant prostate cancer, and to investigate the benefit of a quadrant‐only biopsy approach to analyse whether a quadrant or extended target of the quadrant containing the target only would have been equivalent to systematic biopsy.Patients and MethodsPatients underwent combined systematic mapping and targeted transperineal prostate biopsies at a single institution. Biopsies were performed using the Precisionpoint device (Perineologic, Cumberland, MD, USA) under either local anaesthetic (58%, 163/282), i.v. sedation (12%, 34/282) or general anaesthetic (30%, 85/282). A mean (range) of 24 (5–42) systematic and 4.2 (1–11) target cores were obtained. Magnetic resonance imaging (MRI) scans were reported using the Likert scale. Clinically significant cancer was defined as Gleason 7 or above. Histopathological results were correlated with the presence of an MRI abnormality within a spatial quadrant and the other adjoining or non‐adjoining (opposite) quadrants. Histological concordance with radical prostatectomy specimens was analysed.ResultsA total of 282 patients were included in this study. Their mean (range) age was 66.8 (36–80) years, median (range) prostate‐specific antigen level 7.4 (0.91–116) ng/mL and mean prostate volume 45.8 (13–150) mL. In this cohort, 82% of cases (230/282) were primary biopsies and 18% (52/282) were patients on surveillance. In all, 69% of biopsies (195/282) were identified to have clinically significant disease (Gleason ≥3 + 4). Any cancer (Gleason ≥3 + 3) was found in 84% (237/282) of patients. Of patients with clinically significant disease, the target biopsies alone picked up 88% (171/195), with systematic biopsy picking up the additional 12% (24/195) that the target biopsies missed. This altered with Likert score; 73% of Likert score 3 disease was detected by target biopsy, 92% of Likert score 4 and 100% of Likert score 5. Target biopsies with additional same‐quadrant‐only systematic cores picked up 75% (18/24) of significant cancer that was missed on target only, found in the same quadrant as the target.ConclusionSystematic biopsy is still an important tool when evaluating all patients referred for prostate biopsy, but the need is decreased with increasing suspicion on MRI. Patients with very high suspicion of prostate cancer (Likert score 5) may not require systematic cores, unless representative surrounding biopsies are required for other specific treatments (e.g. focal therapy, or operative planning). More prospective studies are needed to evaluate this in full.