bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Temperature on the Stability of In-Use Insulin Pens
Authors: Kongmalai Tanawan , Preechasuk Lukana , Junnu Sarawut , Manocheewa Siriphan , Srisawat Chatchawan , Sriwijitkamol Apiradee 
Published: October 2019

Abstract
Background Improper storage of insulin could decrease its potency. Manufacturers recommend that in-use insulin pens should be kept at between 25–30°C, but room temperature in tropical countries often exceeds this range. This study investigates the effect of temperature on the stability of basal insulin in cartridges 28 days after opening.
Methods Four different basal insulins were evaluated. Five opened pens of each insulin type were included for each of three storage conditions and 5 unopened insulin pens of each type were stored in the refrigerator as a control. The opened pens were stored for 28 days in either a refrigerator (2–8 °C), at room temperature, or in an incubator (37 °C). Each day insulin pens were mixed 20 times and 2 units were discarded to mimic daily usage. Insulin quantity was evaluated using an ultra-high-performance liquid chromatography assay.
Results The average room temperature during the study period was 29.7 °C. After 28 days, the percentage amount of insulin stored at refrigerator, room temperature or incubator, compared with control was 99.0, 99.7, 101.1% for long-acting insulin; 97.4, 97.2, 99.0% for NPH-1; 101.4, 101.5, 100.7% for NPH-2; and 98.7, 97.8, 98.5% for NPH-3. There were no statistically significant differences. However, we observed a trend toward different stability between clear insulin analog and turbid NPH insulin.
Conclusions Temperature as high as 37°C and cyclic temperature,had no effect on the stability of in-use insulin pen.
Personbezogene Faktoren im bio-psycho-sozialen Modell der WHO: Systematik der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP)
Authors: Grotkamp Sabine , Cibis Wolfgang , Brüggemann Silke , Coenen M. Michaela , Gmünder Hans-Peter , Keller Klaus , Nüchtern Elisabeth , Schwegler Urban , Seger Wolfgang , Staubli Stefan , Raison B. Bia von , Weißmann R , Bahemann A. , Fuchs H. , Rink M. , Schian Marcus , Schmitt Klaus 
Published: October 2019

Zusammenfassung
Hintergrund Die Arbeitsgruppe „ICF“ des Fachbereichs II „Praktische Sozialmedizin und Rehabilitation“ der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP) entwarf 2010 eine Liste personbezogener Faktoren (PF) für den deutschen Sprachraum. Zwischenzeitlich haben die ICF und das bio-psycho-soziale Modell der WHO eine verstärkte Verankerung im SGB IX gefunden. So hat der Gesetzgeber verbindlich bestimmt, dass im Reha-Prozess eine Bedarfsfeststellung „umfassend“ zu erfolgen hat. Damit sind die PF ein obligatorischer Bestandteil der Bedarfsermittlung.
Ziel Ziel der vorliegenden Arbeit ist es, eine aktualisierte Fassung der PF für die (sozialmedizinische) Begutachtung im deutschen Sprachraum vorzulegen. Dazu erfolgte eine Auseinandersetzung mit bereits publizierten Vorschlägen anderer Autoren, insbesondere mit der Arbeit von Geyh et al.
Methodik Die multiprofessionell zusammengesetzte Arbeitsgruppe überprüfte mittels einer qualitativen Herangehensweise die Grundstruktur, Konsistenz und Faktorenauswahl der DGSMP-Systematik und modifizierte diese, sofern sinnvoll und erforderlich. Die Grundsätze für die Faktorenauswahl wurden analog zur Publikation von 2010 beibehalten.
Ergebnisse Eine grundlegende Anpassung war nicht erforderlich, die Grundstruktur der Systematik blieb im Wesentlichen erhalten. Einige Kategorien wurden ergänzt, gestrichen, zusammengefasst, verschoben sowie redaktionell oder inhaltlich überarbeitet. Eine Systematik zu PF ist als solche datenschutzrechtlich grundsätzlich unbedenklich. Die Zulässigkeit einer Erhebung von einzelnen PF im Rahmen der Bedarfsermittlung und -feststellung wird nach ihrer Erforderlichkeit im konkreten Einzelfall für die Erfüllung der gesetzlichen Aufgaben beurteilt.
Ausblick Die überarbeitete DGSMP-Systematik ermöglicht es dem Anwender, relevante Einflüsse aus dem Lebenshintergrund einer Person strukturiert zu beschreiben und zu dokumentieren. Damit können Einflüsse auf die Teilhabe eines Menschen auf Grundlage des bio-psycho-sozialen Modells umfassend und transparent dargestellt werden. Der Weg zu einer justiziablen Leistungsallokation und umfassenden Nutzung, insbesondere im gesamten Reha-Prozess wird erleichtert.
Pulmonale Hypertonie: Update 2019
Authors: Rosenkranz Stephan 
Published: October 2019

ZUSAMMENFASSUNGPulmonale Hypertonie (PH) ist ein hämodynamischer Zustand, der als gemeinsame Konsequenz einer Reihe von Erkrankungen entstehen kann, die aufgrund unterschiedlicher Pathomechanismen zu einer Erhöhung des pulmonal arteriellen Drucks und infolge dessen zu chronischer Rechtsherzbelastung führen. Je nach zugrunde liegender Ursache untergliedert die klinische Klassifikation die PH in 5 Gruppen: Pulmonal arterielle Hypertonie (Gruppe 1), PH in Zusammenhang mit Linksherzerkrankungen (Gruppe 2), PH bei chronischen Lungenerkrankungen (Gruppe 3), chronisch-thromboembolische PH (CTEPH; Gruppe 4) und PH aufgrund unklarer und/oder multifaktorieller Mechanismen (Gruppe 5). Dieser Artikel fokussiert auf die klinische Relevanz dieser Untergliederung und das unterschiedliche Management der verschiedenen PH-Formen. Er beleuchtet zudem kritisch neue Entwicklungen wie die modifizierte hämodynamische Definition der PH.
Upgrading Therapy Strategy Improves Pregnancy Outcome in Antiphospholipid Syndrome: A Cohort Management Study
Authors: Hoxha Ariela , Favaro Maria , Calligaro Antonia , Del Ross Teresa , Ruffatti Alessandra Teresa , Infantolino Chiara , Tonello Marta , Mattia Elena , Ruffatti Amelia 
Published: October 2019

AbstractThe current study evaluates the efficacy and safety of different treatment strategies for pregnant patients with antiphospholipid syndrome. One hundred twenty-seven consecutive pregnancies were assessed; 87 (68.5%) with a history of pregnancy morbidity alone were treated with prophylactic low molecular weight heparin (LMWH) + low-dose aspirin (LDA, 100 mg) (group I) and 40 (31.5%) with a history of thrombosis and/or severe pregnancy complications with therapeutic LMWH + LDA (group II). LMWH doses were increased throughout the pregnancies depending on the patients' weight gain, and treatment was switched to a more intensive one at the first sign of maternal/fetal complications. The study's primary outcome was live births. There were no significant differences in live birth rate between group I (95.4%) and group II (87.5%). Even fetal complication rate was similar in the two groups; group II nevertheless had a higher prevalence of maternal and neonatal complications (p = 0.0005 and p = 0.01, respectively) and registered a significantly lower gestational age at delivery and birth weight (p = 0.0001 and p = 0.0005, respectively). Two patients in group I switched to group II therapy, six patients in group II switched to a more intensive treatment strategy (weekly plasma exchange + fortnightly intravenous immunoglobulins in addition to therapeutic LMWH + LDA). The multivariate analysis uncovered that triple antiphospholipid antibodies positivity was an independent factor leading to a more intensive therapy. All eight switched patients achieved a live birth. Study results revealed that adjusted LMWH doses and switching therapy at first signs of severe pregnancy complications led to a high rate of live births in antiphospholipid syndrome patients.
Familial Sleep Disorders in Unknown Genetic Syndrome
Authors: Lelii Mara , Baggi Elena , Senatore Laura , Bedeschi Maria Francesca , Dilena Robertino , Iascone Maria , Gangi Silvana , Marchisio Paola , Patria Maria Francesca 
Published: October 2019

AbstractSleep-disordered breathing (SDB) is common in children, especially in those with congenital or genetic diseases. The factors involved include obstructive sleep apnea, disrupted rapid eye movement sleep, and central hypoventilation. Diagnosing and treating SDB in these children have a positive impact on the quality of life of them and their families, reducing the risk of both further impairment of cognitive abilities and cardiopulmonary complications. We report a familial case of SDB with central hypoventilation, in which identification of the disorder in the younger sister led to the unfortunately late diagnosis and treatment of the same condition in the older sister.
Zumba dancing and aerobic exercise can improve working memory, motor function, and depressive symptoms in female patients with Fibromyalgia
Authors: Norouzi Ebrahim , Hosseini FatemehSadat , Vaezmosavi Mohammad , Gerber Markus , Pühse Uwe , Brand Serge 
Published: October 2019

ABSTRACTBackground: Patients suffering from the Fibromyalgia (FM) have impaired cognitive function, reduced physical activity and more marked depressive symptoms. While physical activity and exercise therapy are not typically part of the standard treatment for this syndrome, there is mounting evidence that regular participation in activities involving physical exertion has a positive impact on psychological functioning in people with FM. This study compares the impact of two different interventions, aerobic exercise training and Zumba dancing, on working memory, motor function and depressive symptoms among female patients with FM. The design also included a control condition. Method: A total of sixty middle‐aged female patients with FM (mean age: 35.76 years) and undergoing standard care took part in the study. Participants were randomly assigned to one of the following three conditions: aerobic exercise training, Zumba dancing, or control. At baseline and 12 weeks later after the end of the intervention, participants’ working memory, motor function and depressive symptom severity were assessed. Results: Working memory, motor function and depressive symptoms improved over time, but only in the aerobic exercise training and Zumba dancing conditions than in the control condition. Post‐hoc analyses showed that improvements were greatest among participants assigned to Zumba dancing, followed by participants who engaged in aerobic exercise training; the scores of the control group remained virtually unchanged. Conclusion: Aerobic exercise training and Zumba dancing can be recommended as add‐ons to standard care to improve working memory and to reduce severity of depressive symptoms among female patients with FM. Although motor function improved in both intervention groups, the effects did not reach clinical relevance.
A general perturbative approach for bead-based microswimmers reveals rich self-propulsion phenomena
Authors: Ziegler Sebastian , Hubert Maxime , Vandewalle Nicolas , Harting Jens , Smith Ana-Sunčana 
Published: October 2019

Abstract
Studies of model microswimmers have significantly contributed to the understanding of the principles of self-propulsion we have today. However, only a small number of microswimmer types have been amenable to analytic modeling, and further development of such approaches is necessary to identify the key features of these active systems. Here we present a general perturbative calculation scheme for swimmers composed of beads interacting by harmonic potentials and via hydrodynamics, driven by an arbitrary force protocol. The approach can be used with mobility matrices of arbitrary accuracy, and we illustrate it with the Oseen and Rotne–Prager approximations. We validate our approach by using 3 bead assemblies and comparing the results with the numerically obtained full-solutions of the governing equations of motion, as well as with existing analytic models for the linear and the triangular swimmer geometry. While recovering the relation between the force and swimming velocity, our detailed analysis and the controlled level of approximation allow us to find qualitative differences already in the far field flow of the devices. Consequently, we are able to identify a behavior of the swimmer that is richer than predicted in previous models. Given its generality, the framework can be applied to any swimmer geometry, driving protocol and bead interactions, as well as in problems involving many swimmers.
Latest results from the XENON1T experiment
Authors: Benabderrahmane M. L. 
Published: October 2019

Abstract
The most successful class of direct detection of WIMPs with masses from few GeV/c2 to TeV/c2 have utilized Liquid Xenon time projection chambers (TPCs). The XENON project adopted dual phase TPCs using ultra-pure liquid Xenon as both target and detection medium for WIMPs. The first ton-scale Liquid Xenon based TPC, XENON1T, is running at the Gran Sasso Laboratory. With an active mass inside the TPC of 2 tonnes, data were collected for 278.8 days live time. Within a fiducial mass of 1.3 tonne, this results in 1.0 tonne×year exposure. In the energy region of interest, the detector exhibits the lowest background ever obtained in direct dark matter search experiment. In these data no significant excess over background is found and the most stringent limits on WIMP-nucleon spin-independent elastic scattering cross section has been set for masses above 6 GeV/c2 with a minimum of 4.1×10−47cm2 at 30 GeV/c2.
Fluctuations in produced charged particle multiplicities in relativistic nuclear collisions for simulated events
Authors: Ahmad M. Ayaz , Baker Jalal Hasan , Rasool Mir Hashim , Ahmad Shafiq , Dobra R. , Pasculescu D. , Telles Charles Roberto 
Published: October 2019

Abstract
The event-by-event (E-by-E) fluctuations have been studied for relativistic heavy ion collisions and compared by theoretical prediction of available event generators. The multiplicity fluctuations are sensitive to QCD phase transition and to the presence of critical point in the QCD phase diagram. These fluctuations also provide baselines for other event-by-event (E-by-E) measurements. In the present article, a modest approach attempt has been made for a logical study of event-by-event (E-by-E) charge fluctuations in the relativistic nuclear collisions of proton-proton (p-p) and nucleus-nucleus (A-A) interactions. Finally, simulations by Monte Carlo Generators (MCGs) have been done and findings were found within good agreements with other works.
Studying Proton–Proton Interaction at Large Hadrons Collider Using Genetic Programming
Authors: Radi Amr 
Published: October 2019

AbstractThis paper describes how to use Genetic Programming (GP) as an evolutionary computational that is a family of algorithms for global optimization. GP, as a global optimization technique used by discovery of a new function for modeling physical phenomena. The p-p interactions are modeled at Large Hadron Collider (LHC) experiments, the number of charged particles multiplicity <n> and the total cross-section, σT, as functions of the total center of mass energy (from low to ultra-high energy),sare discovered by using GP. In view of the discovered function for〈n〉(s), the overall trend of the values predicted is consistent with LHC data [predicted values are 34.8638 and 35.3520 ats=13TeVands=14TeVrespectively]. The new functionσT(s), trained on experimental data of Particle Data Group (PDG) demonstrates a nice match to the other models. The predicted values of the total cross section ats=13TeV, and 14 TeV are found to be 109.0381 mb and 111.8329 mb respectively. Furthermore, the values predicted are agreed with other models like Block
Standard Model: Electroweak Physics with CMS and ATLAS at 13 TeV
Authors: Kaur Sandeep 
Published: October 2019

Abstract
This paper presents cross section measurements for inclusive W/Z boson production, and W/Z boson production in association with jets and diboson production, performed by the CMS [1] and ATLAS [2] collaborations using proton-proton (pp) collisions data at a centre-of-mass energy of

s

=
13
T
e
V

at LHC. Differential and total production cross sections for various processes, are computed and compared to higher order predictions of the standard model (SM). Recent results on effective leptonic weak mixing angle are also presented.
The central light-year of the Milky Way: How stars and gas live in a relativistic environment of a super-massive black hole
Authors: Eckart Andreas , Zajacek Michal , Valencia-S Monica , Parsa Marzieh , Hosseini Elaheh , Straubmeier Christian , Horrobin Mathew , Subroweit Matthias , Tursunov Arman 
Published: October 2019

Abstract
The central region of our Milky Way is extremely active. It harbors the closest galactic nucleus that is accessible to us allowing us to study it in fine detail. Here we present a consice summary of some of the most recent results obtained with state of the art instruments providing sensitive measurements at their highest angular resolution. The central star cluster harbors a small cusp of high velocity mostly young and dusty stars that are in orbit around the 4 million solar mass super massive black hole (SMBH) Sagittarius A* (SgrA*). Molecular and atomic gas is streaming towards this region in the form of a spiral connecting it to the Circum Nuclear Ring. Using the Large Atacama Millimeter Array (ALMA) we investigated the kinematics and composition of this material in detail highlighting signatures of star formation and the interaction with a wind emerging form the direction of SgrA*. Using results from the Very Large Telescope (VLT) we will highlight the dynamics of the ultra-fast stars and present theories on their origin. We demonstrate that one of the innermost stars shows clear signs of relativistic motion in the deep potential well of the SMBH. The interaction of plasma with SgrA* reveals that matter is orbiting and is being accreted onto the SMBH to produce powerful flares. These are detectable all across the electromagnetic spectrum and help us to understand the region close to the event horizon of SgrA* which is currently under investigation using the Event Horizon Telescope (EHT).
Accretion flows around compact objects: stellar wind and neutron stars in massive binaries
Authors: Manousakis Antonios 
Published: October 2019

Abstract
Strong winds from massive stars are a topic of interest to a wide range of astrophysical fields, e.g., stellar evolution, X-ray binaries or the evolution of galaxies. Massive stars, as heavy as 10 to 20 solar masses, generate dense fast outflows that continuously supply their surroundings with metals, kinetic energy and ionizing radiation, triggering star formation and driving the chemical enrichment and evolution of Galaxies. The amount of mass lost through the emission of these winds dramatically affects the evolution of the star. Depending on the mass left at the end of its life, a massive star can explode as a supernova and/or produce a gamma-ray burst, which are among the most powerful probes of cosmic evolution. The study of massive star winds is thus a truly multidisciplinary field and has a wide impact on different areas of astronomy.
In High-Mass X-ray Binaries the presence of an accreting compact object on the one side allows to infer wind parameters from studies of the varying properties of the emitted X-rays; but on the other side the accretors gravity and ionizing radiation can strongly influence the wind flow. As the compact objects, either a neutron star or a black hole, moves through the dense stellar wind, it accretes material from its donor star and therefore emit X-rays. Subsequently these X-rays will affect (heat and photoionize) the stellar environment and alter the ionization structure of the wind. The wind will therefore be more unstable revealing a very rich phenomenology. Using an armada of space based observatories (e.g., XMM-Newton, swift, INTEGRAL, NuSTAR, etc) and data spanning more than 10 years allowed for probing the inner velocity field close to the massive donor as well as neutron star masses estimations. As a result, stellar winds and neutron stars can be now studied in situ, thanks to X-ray observatories and state-of-the-art hydrodynamic simulations for the very first time.
Hot spots analysis of a sample of 98 Fanaroff-Riley II radio sources
Authors: Fernini I , Eckart A 
Published: October 2019

Abstract
This paper reports our final results related to the study of hot spots (HSs) in a sample of 98 Fanaroff-Riley class II (FR II) radio sources using the VLA at 8.4 GHz. The sample contains 52 radio galaxies (RGs) and 46 quasars (QSRs). We discuss the properties of these HSs, i.e., location (edged or recessed), morphology, and size. The main result is that the number of edged (and recessed) HSs is more for the RGs than for the QSRs. Regarding the compactness of these HSs, QSRs tend to have more compact HSs than RGs. We also found a significant correlation between the hot spot size and the source linear size for the RGs, but not for the QSRs. We discuss the overall properties of the HSs in light of the current models of radio sources.
Dynamical study of viscous modified Chaplygin gas and confrontation with recent observational data
Authors: Mebarki N. , Aberkane D. 
Published: October 2019

Abstract
A cosmological Model of viscous modified Chaplygin gas in classical and loop quantum cosmology (LQC) is proposed and a dynamical stability study is investigated. It is shown that the model is consistent with the recent observational data and gives good predictions for the deceleration and state parameters. The model can also predict the time crossing and gives a solution to the coincidence problem. Furthermore, in LQC background, the big bang singularity found in classical cosmology cease to exist and is replaced by a bounce when the Hubble parameter vanishes at the LQC critical energy density.
On the wind accretion model of GX 301-2
Authors: Taani Ali , Karino Shigeyuki , Song Liming , Mardini Mohammad , Al-Wardat Mashhoor , Abushattal Ahmad , Khasawneh Awni , Al-Naimiy Hamid 
Published: October 2019

Abstract
We illustrate the evolution of the peculiar behavior of the high mass X-ray binary GX 301-2, through the wind accretion model. We found that the donor of this system has 43 M⨀ and clearly it experienced of a mass exchange. As a result, the low terminal velocity of the wind from donor (1200 km/s), slow rotation and the relatively low luminosity (3.1×1035erg/s), can easily fed the neutron star via the stellar wind with enough accretion matter. This will lead to explain the observed X-rays. It has been shown that the characteristics of mass-loss rate through stellar winds would reasonably be expected to alter the changes in wind velocity by X-rays.
Near-infrared spectroscopy of Ca-rich clinopyroxenes revisited: A new interpretation of anomalous type-B spectra and implications for remote sensing of inner solar system bodies
Authors: Abdu Yassir A 
Published: October 2019

Abstract
Four Ca-rich clinopyroxene samples (3 terrestrial clinopyroxenes and a druse clinopyroxene from the D’Orbigny meteorite) have been studied by near-infrared (NIR) spectroscopy and X-ray structure refinement in order to address the issue of anomalous type-B NIR spectra seen in some terrestrial and extraterrestrial Ca-rich clinopyroxenes. The D’Orbigny druse clinopyroxene shows a typical type-B NIR spectrum, with two absorption bands located at ~ 1.1 and 2.3 μm. Based on previous Mössbauer and X-ray structure refinement results on synthetic clinopyroxenes, the 1.1 μm band is assigned to Fe2+ at the M1 site in diopside and high-pigeonite (i.e. pigeonite with C2/c symmetry), and the 2.3 μm band to Fe2+ at the M2 site in high-pigeonite. A comparison of NIR spectral type and X-ray structure refinement of the studied samples indicates that the average structure refinement of all type-B clinopyroxenes show a residual electron density peak in the difference-Fourier synthesis, corresponding to the split M2’ site which is mainly occupied by Fe2+. The results present a new interpretation for type-B NIR spectra of Ca-rich clinopyroxenes.