bluuebunny/crossref_metadata_2025_split huggingface dataset:
The main contributions of robust statistics to statistical science and a new challenge
Authors: Ronchetti Elvezio 
Published: August 2020

AbstractIn the first part of the paper, we trace the development of robust statistics through its main contributions which have penetrated mainstream statistics. The goal of this paper is neither to provide a full overview of robust statistics, nor to make a complete list of its tools and methods, but to focus on basic concepts that have become standard ideas and tools in modern statistics. In the second part we focus on the particular challenge provided by high-dimensional statistics and discuss how robustness ideas can be used and adapted to this situation.
Measurement and refactoring for package structure based on complex network
Authors: Zhou Yangxi , Mi Yanran , Zhu Yan , Chen Liangyu 
Published: August 2020

AbstractSoftware structure is the backbone for software systems. During the long time of software evolution, it is gradually weakened by continuous code modification and expansion driven by new requirements. Therefore, measuring software and refactoring codes are necessary to keep software structure stable and clean. In this paper, we propose two metrics of cohesion and coupling to characterize package structure. We consider not only the dependencies of intra-package and inter-package, but also the backward dependencies of inter-package. The two metrics are proved theoretically that they are satisfied with Briand’s four properties. Based on these metrics, a refactoring algorithm is presented to improve the quality of package structure. Through tests on ten open source software systems, the experiment result shows our metrics can measure software structure correctly and improve codes to fit for the rule of high cohesion and low coupling.
Adsorptive Removal Of Ni2+ Ions From Aqueous Solutions by Nodular Sepiolite (Meerschaum) and Industrial Sepiolite Samples From Eskişehir, Turkey
Authors: Kıpçak İlker , Kurtaran Ersal Emel , Özdemir Mine 
Published: August 2020

AbstractHeavy metals in the environment are a problem due to their toxicity and bioaccumulation. Adsorptive removal of heavy metals by clay minerals has garnered increasing attention due to the abundance, low cost, and exceptional physicochemical properties of the clays. The purpose of the present study was to investigate the utilization of two Turkish sepiolite samples, nodular sepiolite (NS) and industrial sepiolite (IS), as adsorbents in removing Ni2+ ions from aqueous solutions. The specific surface areas of NS and IS are 182.19 m2 g–1 and 63.78 m2 g–1, respectively. The effects of adsorbent dosage, initial pH, contact time, initial concentration, and temperature on the adsorption of Ni2+ ions onto the sepiolite samples were investigated using a batch method. The optimum adsorbent dosage was determined as 0.6 g/50 mL of adsorbent and the optimum pH value was 6.0, for both sepiolite samples. The adsorption process obeyed the Freundlich isotherm model (KF: 4.89–9.73 mg1–1/n L1/n g–1 for NS and 4.27–6.42 mg1–1/n L1/n g–1 for IS) and the pseudo-second order kinetics model (k2: 0.0049–0.0397 g mg–1 min–1 for NS and 0.0688–0.1195 g mg–1 min–1 for IS). The adsorption process was spontaneous and endothermic, and the randomness increased. The samples exhibited large adsorption capacities through three cycles of adsorption-desorption tests. The results revealed that the sepiolite samples are promising as cost-effective adsorbents for the removal of Ni2+ ions from aqueous solutions.
Pelvic Floor Biometric Changes Assessed by 4D Translabial Ultrassound in Women with Vulvodynia Submitted to Physical Therapy: A Pilot Study of a Randomized Controlled Trial
Authors: Bardin Marcela Grigol , Giraldo Paulo César , Martinho Natalia 
Published: August 2020

Abstract

Background
Vulvodynia is a disabling condition in which pelvic floor muscles' (PFM) hypertonicity plays an important role.

Aim
To evaluate biometric changes in PFM in women with vulvodynia undergoing kinesiotherapy treatment protocol (KTP).

Methods
A single-blinded randomized controlled trial of 57 women with vulvodynia randomly assigned to either KTP + amitriptyline or amitriptyline alone (controls) for treatment. Four-dimensional translabial ultrasound assessed PFM regarding symphysis-levator distance at rest, anorectal angle at rest, excursion of the levator plate angle, and levator hiatal narrowing. Volunteers underwent a vaginal examination for a cotton swab test (CST), fulfillment of Friedrich criteria score and PFM power of contraction, and completed a diary of sexual pain and frequency of vaginal intercourse. Outcomes were assessed at baseline and after 8 weeks of treatment.

Outcomes
Primary outcomes were differences in biometric parameters assessed by four-dimensional translabial ultrasound after treatment, between groups. Secondary outcomes were changes in clinical variables (CST, Friedrich criteria, PFM power of contraction, frequency of intercourse, and intensity of sexual pain) between groups and correlation analysis between biometric parameters and clinical variables.

Results
Only the KTP group had statistically significant changes in biometric parameters after treatment (symphysis-levator distance: 0.22 ± 0.2, 95% CI = 0.1–0.4, P = .008; levator hiatal narrowing: −0.33 ± 0.2, 95% CI = −1 to −0.2, P = .04). Comparisons between groups showed that symphysis-levator distance (0.3, 95% CI = 0.2–0.6, P = .005) and excursion of levator plate angle (4.9, 95% CI = −0.4 to 10.1, P = .02) improved significantly after KTP treatment. Clinical variables showed greater improvement in the group treated with KTP for CST (difference of −3.7, 95% CI = −7 to −0.4, P = .01), Friedrich criteria (difference of −1.9, 95% CI = −3.2 to −0.6, P = .003), PFM power of contraction (0.3, 95% CI = 0.1–0.6, P = .05) and intensity of sexual pain (reduction of 1.7, 95% CI = −3.1 to −0.2, P = .01). Some clinical and biometric variables correlated positively, for example, frequency of vaginal intercourse and anorectal angle (P = .04; r = 0.25), or inversely, for example, pain intensity at CST and anorectal angle (P = .004, r = −0.31).

Clinical Implications
This study provides evidence on efficiency of a physical therapy protocol for improvement of symptoms of vulvodynia and hypertonicity changes.

Conclusion
This pilot study suggests that KTP for women with vulvodynia promoted significant changes in PFM biometric measures, consistent with alterations in hypertonicity and clinical improvement.
Home working and cyber security – an outbreak of unpreparedness?
Authors: Furnell Steven , Shah Jayesh Navin 
Published: August 2020

Home working has been one of the long-promised freedoms of information technology. But until recently it was something that relatively few people had routinely experienced in practice (aside, perhaps, from taking work home to do in the evenings and at weekends). This situation abruptly changed in early 2020, with the Covid-19 pandemic forcing organisations to shut their doors and send staff home. Across the globe, home working wherever possible became the standard advice, and technology was the fundamental enabler of the change. That has changed. With the Covid-19 pandemic, home working became the standard advice, and technology was the fundamental enabler. Steven Furnell of the University of Nottingham and Jayesh Navin Shah of Ipsos MORI examine the extent to which organisations and their staff were prepared for the unplanned outbreak of home working, along with the increased cyberthreats that came with it.
Ferrofluid thin films for aerofoil lift enhancement and delaying flow separation
Authors: Arias F.J. 
Published: August 2020

ABSTRACTIn this work, consideration is given to a novel concept for aerofoil lift enhancement and delaying flow separation. Here, lift enhancement is attained by preventing the growth of the boundary layer through the elimination of the zero-slip condition between the wing surface and the air stream. The concept would simulate all the effects of a moving wall, leading to the appearance of a slip velocity at the gas–fluid interface, including the injection of momentum into the air boundary layer, but with one exception: here there is no moving wall but instead a ferrofluid thin film pumped parallel and attached to the wall by a magnetic field. Utilising a simplified physical model for the velocity profile of the ferrofluid film and based on ferrohydrodynamic stability considerations, an analytical expression for the interfacial velocity is derived. Finally, from the available experimental data on moving walls, the expected lift and angle-of-attack enhancement are found as well as the weight penalty per unit surface area of the wing is estimated. Additional research and development is required to explore the possibilities of using ferrofluid thin films.
Attached and Apart: Attachment Styles and Self-Disclosure in Long-Distance Romantic Relationships
Authors: Hammonds Joshua R. , Ribarsky Elizabeth , Soares Guilherme 
Published: August 2020

AbstractThe primary goal of this study was to examine attachment style effects on self-disclosure, trust, satisfaction, and uncertainty levels of individuals in long-distance romantic relationships (LDRRs) who utilise technologically mediated communication channels as a primary means of daily interaction with their romantic partners. Participants (N= 211) from 27 countries who maintained committed romantic relationships (M= 3 years) with geographical separation (M= 1042 miles,Mdn= 160 miles) were surveyed. Using structural equation modelling (SEM), 7 of the 8 hypotheses were supported, showing that attachment style and self-disclosure predict relational uncertainty, trust, and relational satisfaction. In examining the distinctions between attachment styles (i.e., secure, preoccupied, fearful-avoidant, and dismissive) three models were developed and confirmed with good fit. The implications of the study suggest how both attachment style and self-disclosure influence the overall success of LDRRs.
Role of nutritional composition in the development and survival of Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) on artificial diet and natural hosts
Authors: da Silva Ivana F. , Baldin Edson Luiz L. , Specht Alexandre , Roque-Specht Vânia F. , Morando Rafaela , Malaquias Juaci V. , Paula-Moraes Silvana V. 
Published: August 2020

AbstractHelicoverpa armigera is a pest of several crops causing significant economic impact. We evaluated the insect development on different vegetative and reproductive structures of cotton, maize, and soybean compared to artificial diet. One hundred individuals were evaluated per structure (cotton leaves and bolls; maize leaves, grains, and silk; soybean leaves and pods) and artificial diet. Centesimal analyses were performed on quantifiable nutrient contents in diets. The viability of immatures (eggs, larvae, and pupae) ranged from 30% on maize leaf to 74% on cotton bolls, while on the artificial diet, it was 70%. Maize, cotton, and soybean leaves provided viability of 30, 37, and 42%, respectively, revealing these leaves tissues are less favorable to the development of H. armigera immatures compared to ‘reproductive tissues’. Centesimal composition of diets compared 14 common components in all diets, which correlated significantly with larval and pupal stages and/or pupal weight. Of the 12 dietary components that significantly affected larval development time, half were negatively correlated, indicating a decrease in developmental time from their increments. In general, when insects were confined separately to substrates, the artificial diet was the most suitable for H. armigera development compared to the evaluated natural diets. However, in natural conditions, the variability of available hosts must be considered. In addition, it is acceptable for moths to select more suitable hosts for oviposition, while their larvae move to other more suitable tissues of the same plant or even migrate to other plants.
Increasing molecular diagnostic capacity and COVID-19 incidence in Brazil
Authors: Grotto Rejane Maria Tommasini , Santos Lima Rodrigo , de Almeida Gabriel Berg , Ferreira Claudia Pio , Guimarães Raul Borges , Pronunciate Micheli , Azevedo Edmur , Catão Rafael de Castro , Fortaleza Carlos Magno Castelo Branco 
Published: August 2020

Abstract
Different countries have adopted strategies for the early detection of SARS-CoV-2 since the declaration of community transmission by the World Health Organization (WHO) and timely diagnosis has been considered one of the major obstacles for surveillance and healthcare. Here, we report the increase of the number of laboratories to COVID-19 diagnosis in Brazil. Our results demonstrate an increase and decentralisation of certified laboratories, which does not match the much higher increase in the number of COVID-19 cases. Also, it becomes clear that laboratories are irregularly distributed over the country, with a concentration in the most developed state, São Paulo.
Am I Pretty? 10 Tips to Designing Visually Appealing Slideware Presentations
Authors: Pole Antoinette , Parashar Sangeeta 
Published: August 2020

ABSTRACTThe importance of slideware presentations at conferences remains underestimated. Although several articles in the profession focus on this topic, emphasis on aspects of design and aesthetics appears scant. Changing trends and advances in software, instructional design, and human–computer interactions demand political scientists adapt and pay greater attention to balance and harmony, learning to distinguish between design and decoration. Building on Salmond and Smith’s (2011) work, this article offers 10 tips for creating cleaner, more visually appealing, minimalist slideware presentations. In a world of smartphones and social media, audiences are accustomed to visual aids; therefore, clearly and succinctly conveying a presenter’s core argument and/or results is not only crucial but also paramount.
Comparison of 2,4-D, dicamba and halauxifen-methyl alone or in combination with glyphosate for preplant weed control
Authors: Askew M. Carter , Cahoon Charles W. , York Alan C. , Flessner Michael L. , Langston David B. , Ferebee J. Harrison 
Published: August 2020

AbstractA field study was conducted in 2017 and 2018 to determine foliar efficacy of halauxifen-methyl, 2,4-D, or dicamba applied alone and in combination with glyphosate at preplant burndown timing. Experiments were conducted near Painter, VA; Rocky Mount, NC; Jackson, NC; and Gates, NC. Control of horseweed, henbit, purple deadnettle, cutleaf evening primrose, curly dock, purple cudweed, and common chickweed were evaluated. Halauxifen-methyl applied at 5 g ae ha−1 controlled small and large horseweed 89% and 79%, respectively, and was similar to control by dicamba applied at 280 g ae ha−1. Both rates of 2,4-D—533 g ae ha−1(low rate [LR]) or 1,066 g ae ha−1 (high rate [HR])—were less effective than halauxifen-methyl and dicamba for controlling horseweed. Halauxifen-methyl was the only auxin herbicide to control henbit (90%) and purple deadnettle (99%). Cutleaf evening primrose was controlled 74% to 85%, 51%, and 4% by 2,4-D, dicamba, and halauxifen-methyl, respectively. Dicamba and 2,4-D controlled curly dock 59% to 70% and were more effective than halauxifen-methyl (5%). Auxin herbicides applied alone controlled purple cudweed and common chickweed 21% or less. With the exception of cutleaf evening primrose (35%) and curly dock (37%), glyphosate alone provided 95% or greater control of all weeds evaluated. These experiments demonstrate halauxifen-methyl effectively (≥79%) controls horseweed, henbit, and purple deadnettle, whereas common chickweed, curly dock, cutleaf evening primrose, and purple cudweed control by the herbicide is inadequate (≤7%).
Influence of glyphosate on corn hybrid tolerance to tolpyralate + atrazine
Authors: Langdon Nicole M. , Soltani Nader , Raeder Alan J. , Hooker David C. , Robinson Darren E. , Sikkema Peter H. 
Published: August 2020

AbstractThis study consisting of six field experiments was conducted in 2018 and 2019 to evaluate the tolerance of four corn hybrids (P9998AM, P9840AM, DKC42-60RIB, and DKC43-47RIB) to the tank mix of tolpyralate + atrazine with a commercial glyphosate formulation. At 1 wk after application (WAA), two corn hybrids (P9998AM and P9840AM) exhibited more injury from tolpyralate + atrazine (2× rate) applied alone and in combination with glyphosate than DKC42-60RIB and DKC43-47RIB; however, all corn hybrids responded similarly with respect to visible injury 2, 4, and 8 WAA, stand loss, and yield. Application of tolpyralate + atrazine or glyphosate + tolpyralate + atrazine at the 2× rate caused greater corn injury (up to 27%) than tolpyralate + atrazine or glyphosate + tolpyralate + atrazine at the 1× rate (up to 8%) at 1 WAA. The addition of commercial glyphosate with tolpyralate + atrazine did not enhance injury symptoms. Results of this study show that there is a wide margin of corn safety with tolpyralate + atrazine applied alone and in combination with a commercial formulation of glyphosate.
Management of glyphosate-resistant Palmer amaranth (Amaranthus palmeri) in 2,4-D–, glufosinate-, and glyphosate-resistant soybean
Authors: Shyam Chandrima , Chahal Parminder S. , Jhala Amit J. , Jugulam Mithila 
Published: August 2020

AbstractGlyphosate-resistant (GR) Palmer amaranth is a problematic, annual broadleaf weed in soybean production fields in Nebraska and many other states in the United States. Soybean resistant to 2,4-D, glyphosate, and glufosinate (Enlist E3TM) has been developed and was first grown commercially in 2019. The objectives of this research were to evaluate the effect of herbicide programs applied PRE, PRE followed by (fb) late-POST (LPOST), and early-POST (EPOST) fb LPOST on GR Palmer amaranth control, density, and biomass reduction, soybean injury, and yield. Field experiments were conducted near Carleton, NE, in 2018, and 2019 in a grower’s field infested with GR Palmer amaranth in 2,4-D–, glyphosate-, and glufosinate-resistant soybean. Sulfentrazone + cloransulam-methyl, imazethapyr + saflufenacil + pyroxasulfone, and chlorimuron ethyl + flumioxazin + metribuzin applied PRE provided 84% to 97% control of GR Palmer amaranth compared with the nontreated control 14 d after PRE. Averaged across herbicide programs, PRE fb 2,4-D and/or glufosinate, and sequential application of 2,4-D or glufosinate applied EPOST fb LPOST resulted in 92% and 88% control of GR Palmer amaranth, respectively, compared with 62% control with PRE-only programs 14 d after LPOST. Reductions in Palmer amaranth biomass followed the same trend; however, Palmer amaranth density was reduced 98% in EPOST fb LPOST programs compared with 91% reduction in PRE fb LPOST and 76% reduction in PRE-only programs. PRE fb LPOST and EPOST fb LPOST programs resulted in an average soybean yield of 4,478 and 4,706 kg ha−1, respectively, compared with 3,043 kg ha−1in PRE-only programs. Herbicide programs evaluated in this study resulted in no soybean injury. The results of this research illustrate that herbicide programs are available for the management of GR Palmer amaranth in 2,4-D–, glyphosate-, and glufosinate-resistant soybean.
LncRNA SNHG14 promotes hepatocellular carcinoma progression via H3K27 acetylation activated PABPC1 by PTEN signaling
Authors: Zhang Hui , Xu Hong-Bo , Kurban Erxat , Luo Hong-Wu 
Published: August 2020

AbstractHepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. LncRNA small nucleolar RNA host gene 14 (SNHG14) functions as an oncogene in a variety of cancers. However, the role of SNHG14 in HCC remains elusive. The aim of this study is to unravel the functional role and regulatory mechanism of SNHG14 in HCC. A cohort of 40 HCC tumor tissues and paired adjacent normal tissues were collected. Histopathological changes were analyzed by hematoxylin and eosin and immunohistochemistry. qRT-PCR and western blotting were performed to determine the levels of SNHG14, PABPC1, and PTEN signaling molecules. CCK-8, immunofluorescence, and colony formation assays were conducted to monitor cell proliferation. Wound healing and tube formation assays were employed to determine cell migration and angiogenesis. ChIP assay was performed to investigate the enrichment of H3K27 acetylation in PABPC1 promoter. Xenograft mice model was constructed to further verify the SNHG14/PABPC1 axis in vivo. SNHG14 was highly expressed in HCC tissues and cells, which promoted cell proliferation, migration, and angiogenesis in Hep3B and HepG2 cells. PABPC1 functioned as a downstream effector of SNHG14. SNHG14 dramatically induced upregulation of PABPC1 via H3K27 acetylation. In addition, SNHG14/PABPC1 promoted cell proliferation and angiogenesis via PTEN signaling pathway in vitro and in vivo. SNHG14 promoted cell proliferation and angiogenesis via upregulating PABPC1 through H3K27 acetylation and modulating PTEN signaling in the tumorigenesis of HCC.
FYN is required for ARHGEF16 to promote proliferation and migration in colon cancer cells
Authors: Yu Bei , Xu Linlin , Chen Limin , Wang Yao , Jiang Hongying , Wang Yiting , Yan Yehong , Luo Shiwen , Zhai Zhenyu 
Published: August 2020

AbstractARHGEF16 is a recently identified Rho-family guanine nucleotide exchange factor (GEF) that has been implicated in the activation of Rho-family GTPases such as Rho G, Rac, and Cdc42. However, its functions in colon cancer cell proliferation and migration are not well understood. In this study, we showed that ARHGEF16 was highly expressed in clinical specimens of colon cancer. In colon cancer cells, ARHGEF16-stimulated proliferation and migration in vitro and in vivo. Furthermore, we identified a nonreceptor tyrosine kinase, FYN, as a novel partner of ARHGEF16. Knocking down FYN expression decreased ARHGEF16 protein level in colon cancer cells. We further demonstrated that ARHGEF16-induced colon cancer cell proliferation and migration were dependent on FYN since knockdown FYN abolished the ARHGEF16-induced proliferation and migration of colon cancer cells. The FYN-ARHGEF16 axis mediates colon cancer progression and is a potential therapeutic target for colon cancer treatment.
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease
Authors: Zhang Ye , Zhao Shuang , Fu Ying , Yan Lu , Feng Yilu , Chen Yaqi , Wu Yijia , Deng Yalan , Zhang Guiying , Chen Zhuchu , Chen Yongheng , Liu Ting 
Published: August 2020

AbstractAlcoholic liver disease (ALD) is a chronic alcohol-induced disorder of the liver for which there are few effective therapies for severe forms of ALD and for those who do not achieve alcohol abstinence. In this study, we used a systematic drug-repositioning bioinformatics approach querying a large compendium of gene-expression profiles to identify candidate U.S. Food and Drug Administration (FDA)–approved drugs to treat ALD. One of the top compounds predicted to be therapeutic for ALD by our approach was dimethyl fumarate (DMF), an nuclear factor erythroid 2-related factor 2 (NRF2) inducer. We experimentally validated DMF in liver cells and in vivo. Our work demonstrates that DMF is able to significantly upregulate the NRF2 protein level, increase NRF2 phosphorylation, and promote NRF2 nuclear localization in liver cells. DMF also reduced the reactive oxygen species (ROS) level, lipid peroxidation, and ferroptosis. Furthermore, DMF treatment could prevent ethanol-induced liver injury in ALD mice. Our results provide evidence that DMF might serve as a therapeutic option for ALD in humans, and support the use of computational repositioning to discover therapeutic options for ALD.