bluuebunny/crossref_metadata_2025_split huggingface dataset:
A convenient approach by using poly‐(HEMA‐co‐NIPAM)/Cu2+ solution sol–gel transition for wound protection and healing
Authors: Wang Yansong , Chu Xin , Sun Yu , Teng Peng , Xia Tianzhi , Chen Yisheng 
Published: July 2020

AbstractRapid and convenient wound healing is crucial for reducing potential post‐traumatic wound complications. In this study, a temperature‐sensitive polymer of poly‐(HEMA‐co‐NIPAM) (PHN) was synthesized by free‐radical polymerization, in which the solution quickly underwent a sol–gel transition above 29°C, thus responding to a typical body temperature and facilitating wound sealing. PHN solution incorporated with copper ions (PHN‐Cu) not only exhibited excellent antibacterial properties, but also expedited wound closure and facilitated tissue angiogenesis. The in vivo and in vitro experiments showed that the PHN‐Cu had a higher wound closure rate and demonstrated an ability to promote skin tissue angiogenesis. Such a versatile, convenient aqueous solution could enable nonprofessionals to promptly treat wounds in a short time after injury, thus providing suitable conditions for later treatment, and can be used as a convenient method to clean wounds.
ERBB2b mRNA isoform encodes a nuclear variant of the ERBB2 oncogene in breast cancer
Authors: Hua Guoqiang , Bergon Aurélie , Cauchy Pierre , Kahn‐Perlès Brigitte , Bertucci François , Birnbaum Daniel , Benkirane‐Jessel Nadia , Imbert Jean 
Published: July 2020

AbstractThe presence of nuclear ERBB2 receptor‐type tyrosine kinase is one of the causes of the resistance to membrane ERBB2‐targeted therapy in breast cancers. It has been previously reported that this nuclear location arises through at least two different mechanisms: proteolytic shedding of the extracellular domain of the full‐length receptor and translation of the messenger RNA (mRNA)‐encoding ERBB2 from internal initiation codons. Here, we report a new mechanism and function where a significant portion of nuclear ERBB2 results from the translation of the variant ERBB2 mRNA under the transcriptional control of a distal promoter that is actively used in breast cancer cells. We show that both membrane ERBB2a and nuclear ERBB2b isoforms are prevalently expressed in breast cancer cell lines and carcinoma samples. The ERBB2b isoform, which is translated from mRNA variant 2, can directly translocate into the nucleus due to the lack of the signal peptide which is required for an intermediate membrane location. Small interfering RNA‐mediated gene silencing showed that ERBB2b can repress ERBB2a expression, encoded by variant 1, whereas ERBB2a activates ERBB2b. Nuclear ERBB2 binding to its own promoter was revealed by chromatin immunoprecipitation assay. Altogether, our results provide new insights into the origin and function of nuclear ERBB2 where it can participate at the same time in a positive or a negative feedback autoregulatory loop, dependent on which of its promoters this bona fide transcription factor is acting. They also provide a new understanding for the resistance to therapies targeting the membrane‐anchored ERBB2 in breast cancer.
Caring for others without losing yourself: An adaptation of the Mindful Self‐Compassion Program for Healthcare Communities
Authors: Neff Kristin D. , Knox Marissa C. , Long Phoebe , Gregory Krista 
Published: July 2020

AbstractObjectiveTwo studies examined the efficacy of the Self‐Compassion for Healthcare Communities (SCHC) program for enhancing wellbeing and reducing burnout among healthcare professionals.MethodStudy 1 (N = 58) had a quasi‐experimental design and compared wellbeing outcomes for the SCHC group compared to a waitlist control group. Study 2 (N = 23) did not include a control group and examined the effect of SCHC on burnout.ResultsStudy 1 found that SCHC significantly increased self‐compassion and wellbeing. All gains were maintained for three months. Study 2 found that in addition to enhancing wellbeing, SCHC significantly reduced secondary traumatic stress and burnout. Changes in self‐compassion explained gains in other outcomes, and initial levels of self‐compassion moderated outcomes so that those initially low in self‐compassion benefitted more.ConclusionsFindings suggest that the SCHC program may be an effective way to increase self‐compassion, enhance wellbeing, and reduce burnout for healthcare professionals.
Asymptomatic long‐segmental type A aortic dissection diagnosed by transthoracic echocardiography: A case report and literature review
Authors: Wang Jiwei , Yao Cai , Wu Yongbing , Lai Bin 
Published: July 2020

AbstractAortic dissection (AD) is a life‐threatening disease. Patients usually experience severe pain in the chest, back, or abdomen, but some patients report a variety of other symptoms without pain. Completely asymptomatic AD is sporadic and probably under‐recognized. The present study aimed to (a) report an extremely rare case of asymptomatic long‐segmental type A AD, wherein exaggeratedly low diastolic blood pressure and broad pulse pressure were the primary signs, and (b) summarize the clinical characteristics of asymptomatic AD through the literature review.
YTHDC1 gene polymorphisms and hepatoblastoma susceptibility in Chinese children: A seven‐center case–control study
Authors: Chen Huitong , Li Yong , Li Li , Zhu Jinhong , Yang Zhonghua , Zhang Jiao , Li Suhong , Xin Yijuan , Xia Huimin , He Jing 
Published: July 2020

AbstractBackgroundHepatoblastoma is a commonly occurring embryonal tumors in children. N6‐methyladenosine (m6A) plays a critical role in gene expression, thus contributing to the occurrence and progression of cancer. RNA splicing is regulated by the nuclear m6A reader YTHDC1, yet the roles of YTHDC1 polymorphisms in hepatoblastoma remain unclear.MethodsWe conducted a seven‐center case–control study to determine the association between YTHDC1 gene polymorphisms (rs2293596 T>C, rs2293595 T>C and rs3813832 T>C) and hepatoblastoma susceptibility. We recruited 313 hepatoblastoma patients and 1446 healthy controls.ResultsThere was no significant association between all of these polymorphisms and hepatoblastoma susceptibility in single locus or combined analysis. Stratification analysis revealed that rs2293596 TC/CC genotype carriers had a higher risk of developing hepatoblastoma in the subgroup of clinical stages III + IV [adjusted odds ratio (OR) = 1.80, 95% confidence interval (CI) = 1.18–2.76, p = 0.007]. In addition, 3 risk genotype carriers are more likely to develop hepatoblastoma in the subgroup of clinical stages III + IV (adjusted OR = 1.80, 95% CI = 1.18–2.76, p = 0.007). Furthermore, false‐positive probability analysis was used to notarize our findings. Haplotype analysis indicated that there was no significant association between inferred haplotypes of YTHDC1 gene based on observed genotypes and hepatoblastoma risk.ConclusionsIn conclusion, our findings suggest that the rs2293596 T>C polymorphism may contribute to hepatoblastoma susceptibly and YTHDC1 gene polymorphisms may have a cumulative effect on hepatoblastoma risk.
Imaging Pulmonary Blood Flow Using Pseudocontinuous Arterial Spin Labeling (PCASL) With Balanced Steady‐State Free‐Precession (bSSFP) Readout at 1.5T
Authors: Seith Ferdinand , Pohmann Rolf , Schwartz Martin , Küstner Thomas , Othman Ahmed E. , Kolb Manuel , Scheffler Klaus , Nikolaou Konstantin , Schick Fritz , Martirosian Petros 
Published: July 2020

BackgroundQuantitative assessment of pulmonary blood flow and visualization of its temporal and spatial distribution without contrast media is of clinical significance.PurposeTo assess the potential of electrocardiogram (ECG)‐triggered pseudocontinuous arterial spin labeling (PCASL) imaging with balanced steady‐state free‐precession (bSSFP) readout to measure lung perfusion under free‐breathing (FB) conditions and to study temporal and spatial characteristics of pulmonary blood flow.Study TypeProspective, observational.SubjectsFourteen volunteers; three patients with pulmonary embolism.Field Strength/Sequences1.5T, PCASL‐bSSFP.AssessmentThe pulmonary trunk was labeled during systole. The following examinations were performed: 1) FB and timed breath‐hold (TBH) examinations with a postlabeling delay (PLD) of 1000 msec, and 2) TBH examinations with multiple PLDs (100–1500 msec). Scan–rescan measurements were performed in four volunteers and one patient. Images were registered and the perfusion was evaluated in large vessels, small vessels, and parenchyma. Mean structural similarity indices (MSSIM) was computed and time‐to‐peak (TTP) of parenchymal perfusion in multiple PLDs was evaluated. Image quality reading was performed with three independent blinded readers.Statistical TestsWilcoxon test to compare MSSIM, perfusion, and Likert scores. Spearman's correlation to correlate TTP and cardiac cycle duration. The repeatability coefficient (RC) and within‐subject coefficient of variation (wCV) for scan–rescan measurements. Intraclass correlation coefficient (ICC) for interreader agreement.ResultsImage registration resulted in a significant (P < 0.05) increase of MSSIM. FB perfusion values were 6% higher than TBH (3.28 ± 1.09 vs. 3.10 ± 0.99 mL/min/mL). TTP was highly correlated with individuals' cardiac cycle duration (Spearman = 0.89, P < 0.001). RC and wCV were better for TBH than FB (0.13–0.19 vs. 0.47–1.54 mL/min/mL; 6–7 vs. 19–60%). Image quality was rated very good, with ICCs 0.71–0.89.Data ConclusionECG‐triggered PCASL‐bSSFP imaging of the lung at 1.5T can provide very good image quality and quantitative perfusion maps even under FB. The course of labeled blood through the lung shows a strong dependence on the individuals' cardiac cycle duration.Level of Evidence2Technical Efficacy Stage2 J. MAGN. RESON. IMAGING 2020;52:1767–1782.
Spin‐phonon coupling and two‐magnons scattering behaviors in hexagonal NiAs‐type antiferromagnetic MnTe epitaxial films
Authors: Zhang Jiyue , Lian Qin , Pan Zhiqiang , Bai Wei , Yang Jing , Zhang Yuanyuan , Tang Xiaodong , Chu Junhao 
Published: July 2020

AbstractTemperature‐dependent Raman scattering spectra of NiAs‐type MnTe epitaxial films were measured to explore the temperature evolution of phonon modes and especially the spin‐phonon coupling across Néel temperature (TN). A significant deviation from an anharmonic mode below TN strongly supports the existence of spin‐phonon interaction, and its coupling strength is calculated to be approximately −0.16 cm−1 from the E2g phonon. Two‐magnons (2M) scattering is found, which is proposed to closely relate to the nearest neighbor (NN) exchange interaction. These data elucidate the nature of the spin‐phonon coupling in antiferromagnetic (AFM) MnTe and can avail to develop MnTe‐based AFM spintronic devices.
Theoretical study on the HACA chemistry of naphthalenyl radicals and acetylene: The formation of C12H8, C14H8, and C14H10 species
Authors: Chu Te‐Chun , Smith Mica C. , Yang Jeehyun , Liu Mengjie , Green William H. 
Published: July 2020

AbstractThe hydrogen‐abstraction‐C2H2‐addition (HACA) chemistry of naphthalenyl radicals has been studied extensively, but there is a significant discrepancy in product distributions reported or predicted in literature regarding appearance of C14H8 and C14H10 species. Starting from ab initio calculations, a comprehensive theoretical model describing the HACA chemistry of both 1‐ and 2‐naphthalenyl radicals is generated. Pressure‐dependent kinetics are considered in the C12H9, C14H9, and C14H11 potential energy surfaces including formally direct well‐skipping pathways. On the C12H9 PES, reaction pathways were found connecting two entry points: 1‐naphthalenyl (1‐C10H7) + acetylene (C2H2) and 2‐C10H7 + C2H2. A significant amount of acenaphthylene is predicted to be formed from 2‐C10H7 + C2H2, and the appearance of C14H8 isomers is predicted in the model simulation, consistent with high‐temperature experimental results from Parker et al. At 1500 K, 1‐C10H7 + C2H2 mostly generates acenaphthylene through a formally direct pathway, which predicted selectivity of 66% at 30 Torr and 56% at 300 Torr. The reaction of 2‐C10H7 with C2H2 at 1500 K yields 2‐ethynylnaphthalene as the most dominant product, followed by acenaphthylene mainly generated via isomerization of 2‐C10H7 to 1‐C10H7. Both the 1‐C10H7 and 2‐C10H7 reactions with C2H2 form some C14H8 products, but negligible phenanthrene and anthracene formation is predicted at 1500 K. A rate‐of‐production analysis reveals that C14H8 formation is strongly affected by the rates of H‐abstraction from acenaphthylene, 1‐ethynylnaphthalene, and 2‐ethynylnaphthalene, so the kinetics of these reactions are accurately calculated at the high level G3(MP2,CC)//B3LYP/6‐311G** level of theory. At intermediate temperatures like 800 K, acenaphthylene + H are the leading bimolecular products of 1‐C10H7 + C2H2, and 1‐acenaphthenyl radical is the most abundant C12H9 isomer due to its stability. The predicted product distribution of 2‐C10H7 + C2H2 at 800 K, in contrast to the results of Parker et al is predicted to consist primarily of species containing three fused benzene rings—for example, phenanthrene and anthracene—as the leading products, indicating HACA chemistry is valid from two to three ring polycyclic aromatic hydrocarbons under some conditions. Further experiments are needed for validation.
Adverse Event Reporting in Otolaryngology
Authors: Pereira Nicola M. , Sclafani Anthony P. , Kacker Ashutosh 
Published: July 2020

ObjectivesAdverse events are common occurrences in hospitals that detract from quality of care. There are few data on errors in otolaryngology (ENT) and even fewer data comparing ENT to other services.MethodsWe retrospectively reviewed adverse event data collected across a regional hospital network from July 2014 to August 2017. We examined categories of adverse events that occurred most commonly in ENT and compared the number of adverse events reported in ENT to those reported across all other departments. Descriptive analysis and the paired t test were used to analyze the data.ResultsTwo hundred ninety‐one adverse events were reported in ENT departments during the period studied compared to 58,219 events reported across all other specialties. In ENT, the most commonly reported adverse events occurred in the perioperative setting, followed by issues regarding equipment and medical devices and, lastly, airway management. Across all other departments, the most common categories included medication and fluid errors, falls, and safety and security events. ENT departments had significantly higher proportions of perioperative and airway management errors and significantly lower proportions of events related to diagnosis and treatment (P = .004), falls (P < .001), lab results and specimens (P = .001), medication and fluids (P < .001), and safety and security (P < .001).ConclusionPerioperative and airway management errors occur with a statistically higher frequency in ENT compared to other in‐patient and out‐patient departments across hospitals. It is important to analyze adverse event reporting in surgical specialties to ensure the development of appropriate quality initiatives.Level of Evidence4 Laryngoscope, 131:509–512, 2021
Antioxidative, ACE inhibitory and antibacterial activities of soy milk fermented by indigenous strains of lactobacilli
Authors: Singh Brij Pal , Bhushan Bharat , Vij Shilpa 
Published: July 2020

AbstractSoy milk, a derivative of soybean, is an alternative to dairy beverage, but its acceptability is limited worldwide due to unpleasant beany flavour. Fermentation may, however, improve the nutritional and sensory values of soy milk. Thus, post‐fermentation improvement in functional attributes of soy milk were investigated via antioxidant, ACE inhibitory, and antimicrobial activities in this study using five test and one control strains of lactobacilli. Results indicated that soy milk fermented by Lactobacillus rhamnosus strain C25 (LR C25) effectively scavenged more than 60% of the ABTS, DPPH and Hydroxyl radicals generated in in vitro models. Moreover, all the strains showed significantly higher (p < 0.05) antioxidant activity as compared to unfermented soy milk in all three assays performed. Further, Lactobacillus plantarum strain C6 (LP C6) fermented soy milk displayed significantly higher (p < 0.05) percent ACE inhibitory activity (68.40 ± 0.93%) as compared to other tested Lactobacillus isolates, reference strain and unfermented soy milk. It was also observed that LP C6 strongly inhibited the growth of indicator strain of E. coli in the agar well diffusion assay. These strains can therefore be further explored in the preparation of beneficial soy foods and bioactive food supplements for wellbeing.
Combined use of radiocarbon and stable carbon isotopes for the source mixing model in a stream food web
Authors: Ishikawa Naoto F. , Finlay Jacques C. , Uno Hiromi , Ogawa Nanako O. , Ohkouchi Naohiko , Tayasu Ichiro , Power Mary E. 
Published: July 2020

AbstractRadiocarbon natural abundance (Δ14C) has emerged as a useful dietary tracer in freshwater ecology for the past decade, yet its applicability for separating aquatic and terrestrial resources has not been examined quantitatively. Here, we report Δ14C values of stream invertebrates in different functional feeding groups collected from the upper South Fork Eel River watershed, northern California. We found that algae‐grazing insect larvae show low Δ14C values (−43.1 ± 21.8‰, mean ± standard deviation, N = 6), reflecting the signal of dissolved inorganic carbon weathered from ancient inorganic carbon or respiration of old organic carbon. In contrast, the Δ14C values of leaf‐shredding insect larvae (21.7 ± 31.9‰, N = 5) were close to those of contemporary atmospheric CO2 except at the SF Eel River where algal production was highest. The Δ14C values of predators (−6.1 ± 35.7‰, N = 14) were intermediate between those of grazers and shredders. In a Bayesian mixing model, Δ14C provided a more ecologically realistic estimate for terrestrial vs. aquatic source contributions to invertebrates with lower uncertainty (i.e., narrower credible interval) than did the stable carbon isotopes (δ13C). These results demonstrate that Δ14C can be used, in combination with δ13C, to more precisely estimate organic matter sources to stream animals.
Influence of Chemical and Physical Change of Pollen Microgels on Swelling/De‐Swelling Behavior
Authors: Fan Teng‐Fei , Hwang Youngkyu , Ibrahim Mohammed Shahrudin , Ferracci Gaia , Cho Nam‐Joon 
Published: July 2020

AbstractPollen, the male microgametophyte of seed plants, is commonly used as a food and health supplement. Here, a facile method to transform sunflower pollen into pH‐responsive microgels with tailored properties is presented. The structure and morphology of the pollen microgel are characterized by scanning electron microscopy, confocal laser scanning microscopy, and dynamic image particle analysis based on potassium hydroxide treatment with various incubation time and concentration. These pollen microgels exhibit significant volume change under different pH conditions and Ca+/ethylenediaminetetraacetic acid treatment. The results describe the fundamental properties of pollen microgels and pave the way for its future applications, such as “smart” drug carriers.
(Epi)genetic profiling of extraembryonic and postnatal tissues from female monozygotic twins discordant for Beckwith–Wiedemann syndrome
Authors: Fontana Laura , Bedeschi Maria F. , Cagnoli Giulia A. , Costanza Jole , Persico Nicola , Gangi Silvana , Porro Matteo , Ajmone Paola F. , Colapietro Patrizia , Santaniello Carlo , Crippa Milena , Sirchia Silvia M. , Miozzo Monica , Tabano Silvia 
Published: July 2020

AbstractBackgroundBeckwith–Wiedemann syndrome (BWS) is an overgrowth disorder caused by defects at the 11p15.5 imprinted region. Many cases of female monozygotic (MZ) twins discordant for BWS have been reported, but no definitive conclusions have been drawn regarding the link between epigenetic defects, twinning process, and gender. Here, we report a comprehensive characterization and follow‐up of female MZ twins discordant for BWS.MethodsMethylation pattern at 11p15.5 and multilocus methylation disturbance (MLID) profiling were performed by pyrosequencing and MassARRAY in placental/umbilical cord samples and postnatal tissues. Whole‐exome sequencing was carried out to identify MLID causative mutations. X‐chromosome inactivation (XCI) was determined by HUMARA test.ResultsBoth twins share KCNQ1OT1:TSS‐DMR loss of methylation (LOM) and MLID in blood and the epigenetic defect remained stable in the healthy twin over time. KCNQ1OT1:TSS‐DMRLOM was nonhomogeneously distributed in placental samples and the twins showed the same severely skewed XCI pattern. No MLID‐causative mutations were identified.ConclusionThis is the first report on BWS‐discordant twins with methylation analyses extended to extraembryonic tissues. The results suggest that caution is required when attempting prenatal diagnosis in similar cases. Although the causative mechanism underlying LOM remains undiscovered, the XCI pattern and mosaic LOM suggest that both twinning and LOM/MLID occurred after XCI commitment.
Macromolecular proton fraction mapping based on spin‐lock magnetic resonance imaging
Authors: Hou Jian , Wong Vincent Wai‐Sun , Jiang Baiyan , Wang Yi‐Xiang , Wong Grace Lai‐Hung , Chan Anthony Wing‐Hung , Chu Winnie Chiu‐Wing , Chen Weitian 
Published: July 2020

PurposeIn MRI, the macromolecular proton fraction (MPF) is a key parameter of magnetization transfer (MT). It represents the relative amount of immobile protons associated with semi‐solid macromolecules involved in MT with free water protons. We aim to quantify MPF based on spin‐lock MRI and explore its advantages over the existing MPF‐mapping methods.MethodsIn the proposed method, termed MPF quantification based on spin‐lock (MPF‐SL), off‐resonance spin‐lock is used to sensitively measure the MT effect. MPF‐SL is designed to measure a relaxation rate (Rmpfsl) that is specific to the MT effect by removing the R1ρ relaxation due to the mobile water and chemical exchange pools. A theory is derived to quantify MPF from the measured Rmpfsl. No prior knowledge of tissue relaxation parameters, including T1 or T2, is needed to quantify MPF using MPF‐SL. The proposed approach is validated with Bloch‐McConnell simulations, phantom, and in vivo liver studies at 3.0T.ResultsBoth Bloch‐McConnell simulations and phantom experiments show that MPF‐SL is insensitive to variations of the mobile water pool and the chemical exchange pool. MPF‐SL is specific to the MT effect and can measure MPF reliably. In vivo liver studies show that MPF‐SL can be used to detect collagen deposition in patients with liver fibrosis.ConclusionA novel MPF imaging method based on spin‐lock MRI is proposed. The confounding factors are removed, and the measurement is specific to the MT effect. It holds promise for MPF‐sensitive diagnostic imaging in clinical settings.
Communication experiences of family caregivers of hospitalized adults with intellectual and developmental disabilities—A qualitative study
Authors: Charles Marie Lourdes 
Published: July 2020

AbstractAimTo explore communication experiences between family caregivers of adults with intellectual and developmental disabilities (I/DD) and healthcare personnel during hospitalization.DesignA qualitative descriptive study approach with interviews of family caregivers was used.MethodFace‐to‐face, semi‐structured interviews were conducted from June–September 2015 with ten family caregivers of adults with I/DD. Participants were recruited through an advocacy organization in the north‐eastern United States. Data were analysed by content analysis. The Standards for Reporting Qualitative Research was the chosen checklist.ResultsThe four overarching themes: “Need for Advocacy”; “Need for Better Communication”; “Sense of Abandonment”; and “Lack of Confidence” along with 12 subthemes were identified. Overall, participants reported miscommunications leading to instances of mistrust in hospital staff's competence to deliver quality patient care.