bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and Prognostic Value of Acute Coagulopathy After Extensive Severe Burns
Authors: Geng Kang , Liu Yonglin , Yang Yuting , Ding Xiaobin , Tian Xinli , Liu Hongjun , Yan Hong 
Published: February 2020

Abstract
Acute burn-induced coagulopathy (ABIC) occurs after severe burns. However, the incidence, prognostic value, and clinical significance of ABIC after an extensive severe burn remain inconclusive due to wide variances in burn severity and coagulation profile evaluation timings in previous studies. This retrospective study explored the incidence and clinical and prognostic significance of early phase ABIC in 129 adult patients with extensive burns (&gt;50% total body surface area [TBSA]) admitted to the burn centers of two hospitals within 10 hours postburn injury during 2009–2017. Demographics (age and sex) and clinical data (burn severity, vital signs, prehospital fluid replacement volume, hemodynamic parameters, coagulation profile, blood gas, and blood biochemical indicators) were collected upon admission. The incidence of ABIC in patients with severe burns and its relationship with their survival and clinical significance were analyzed. The average postburn interval was 5.7 ± 2.7 hours, and the incidence of ABIC was 31% (40/129). A logistic regression analysis identified ABIC as an independent predictor of 4-week severe mortality due to severe burn. The incidence of ABIC was significantly associated with the total burn area, lactic acid levels upon admission, and postburn admission interval, but not with the prehospital fluid replacement volume. In conclusion, approximately 30% of patients with severe burns developed ABIC within 10 hours postburn, and this condition strongly predicts 4-week mortality. Although burn severity and tissue ischemia/hypoxia are main risk factors for ABIC, the pathogenesis is not fully understood and should be explored in future studies.
The Transit and Light Curve Modeller
Authors: Csizmadia Sz 
Published: February 2020

ABSTRACT
Transit and Light Curve Modeller (TLCM), a computer code with the purpose of analysing photometric time series of transits simultaneously with the out-of-transit light variations and radial velocity curves of transiting/eclipsing binary systems, is presented here. Joint light-curve and radial velocity fits are possible with it. The code is based on the combination of a genetic algorithm and simulated annealing. Binning, beaming, reflection, and ellipsoidal effects are included. Both objects may have their own luminosities and therefore one can use TLCM to analyse the eclipses of both exoplanet and well-detached binary systems. A simplified Rossiter–McLaughlin effect is included in the radial velocity fit, and drifts and offsets of different instruments can also be fitted. The impact of poorly known limb darkening on the Rossiter–McLaughlin effect is shortly studied. TLCM is able to manage red-noise effects via wavelet analysis. It is also possible to add parabolic or user-defined baselines and features to the code. I also predict that light variations due to beaming in some systems exhibiting radial velocity drift should be observed by, e.g. PLATO. The fit of the beaming effect is improved by invoking a physical description of the ellipsoidal effects, which has an impact on the modelling of the relativistic beaming; I also point out the difficulties that are stemming from the fact that beaming and first-order reflection effects have the same form of time dependence. Recipe is given, which describes how to analyse grazing transit events. The code is freely available.
Constraining the Einstein equivalence principle with multi-wavelength observations of polarized blazars
Authors: Yi Shuang-Xi , Zou Yuan-Chuan , Yang Xuan , Liao Bin , Wei Shao-Wen 
Published: February 2020

ABSTRACT
In this paper, we present a novel method to test the Einstein equivalence principle (EEP) using (simultaneous) multi-wavelength radio observations of polarized blazars. We analyse simultaneous multi-wavelength polarization observations of 3C 279 at 22, 43, and 86 GHz obtained by two antennas of the Korean VLBI Network. We obtained 15 groups of polarization data, and applied the Metropolis–Hastings Markov chain (MHMC) to simulate the parameters when considering the EEP effect and the simplest form of Faraday rotation (single external Faraday screen). The final results show the constraint of the parametrized post-Newtonian (PPN) parameter γ discrepancy as Δγp = (1.91 ± 0.34) × 10−20. However, the single external Faraday screen is an oversimplification for blazars because there are numerous observations showing complex Faraday rotation behaviour for blazars due to internal/external Faraday dispersion, beam depolarization, etc. The Δγp results of this paper can only be considered as upper limits. Only if all other effects are revealed and considered should the result be taken as a direct measurement of the violation of the EEP.
The VIRUS-P Exploration of Nearby Galaxies (VENGA): the stellar populations and assembly of NGC 2903’s bulge, bar, and outer disc
Authors: Carrillo Andreia , Jogee Shardha , Drory Niv , Kaplan Kyle F , Blanc Guillermo , Weinzirl Tim , Song Mimi , Luo Rongxin 
Published: February 2020

ABSTRACT
We study the stellar populations and assembly of the nearby spiral galaxy NGC 2903’s bulge, bar, and outer disc using the VIRUS-P Exploration of Nearby Galaxies IFS survey. We observe NGC 2903 with a spatial resolution of 185 pc using the Mitchell Spectrograph’s 4.25 arcsec fibres at the 2.7 Harlan J. Smith telescope. Bulge–bar–disc decomposition on the Two Micron All-Sky Survey (2MASS) Ks-band image of NGC 2903 shows that it has ∼6 per cent, 6 per cent, and 88 per cent, of its stellar mass in the bulge, bar, and outer disc, respectively, and its bulge has a low Sérsic index of ∼0.27, suggestive of a discy bulge. We perform stellar population synthesis and find that the outer disc has 46 per cent of its mass in stars &gt;5 Gyr, 48 per cent in stars between 1 and 5 Gyr, and &lt;10 per cent in younger stars. Its stellar bar has 65 per cent of its mass in ages 1–5 Gyr and has metallicities similar to the outer disc, suggestive of the evolutionary picture where the bar forms from disc material. Its bulge is mainly composed of old high-metallicity stars though it also has a small fraction of young stars. We find enhanced metallicity in the spiral arms and central region, tracing areas of high star formation as seen in the Hα map. These results are consistent with the idea that galaxies of low bulge-to-total mass ratio and low bulge Sérsic index like NGC 2903 has not had a recent major merger event, but has instead grown mostly through minor mergers and secular processes.
Phase-space structure of cold dark matter haloes inside splashback: multistream flows and self-similar solution
Authors: Sugiura Hiromu , Nishimichi Takahiro , Rasera Yann , Taruya Atsushi 
Published: February 2020

ABSTRACT
Using the motion of accreting particles on to haloes in cosmological N-body simulations, we study the radial phase-space structures of cold dark matter (CDM) haloes. In CDM cosmology, formation of virialized haloes generically produces radial caustics, followed by multistream flows of accreted dark matter inside the haloes. In particular, the radius of the outermost caustic called the splashback radius exhibits a sharp drop in the slope of the density profile. Here, we focus on the multistream structure of CDM haloes inside the splashback radius. To analyse this, we use and extend the SPARTA algorithm developed by Diemer. By tracking the particle trajectories accreting on to the haloes, we count their number of apocentre passages, which is then used to reveal the multistream flows of the dark matter particles. The resultant multistream structure in radial phase space is compared with the prediction of the self-similar solution by Fillmore & Goldreich for each halo. We find that $\sim \!30{{\ \rm per\ cent}}$ of the simulated haloes satisfy our criteria to be regarded as being well fitted to the self-similar solution. The fitting parameters in the self-similar solution characterize physical properties of the haloes, including the mass accretion rate and the size of the outermost caustic (i.e. the splashback radius). We discuss in detail the correlation of these fitting parameters and other measures directly extracted from the N-body simulation.
Accelerated orbital decay of supermassive black hole binaries in merging nuclear star clusters
Authors: Ogiya Go , Hahn Oliver , Mingarelli Chiara M F , Volonteri Marta 
Published: February 2020

ABSTRACT
The coalescence of supermassive black holes (SMBHs) should generate the strongest sources of gravitational waves (GWs) in the Universe. However, the dynamics of their coalescence is the subject of much debate. In this study, we use a suite of N-body simulations to follow the merger of two nuclear star clusters (NSCs), each hosting an SMBH in their centre. We find that the presence of distinct star clusters around each SMBH has important consequences for the dynamical evolution of the SMBH binary: (i) The separation between the SMBHs decreases by a few orders of magnitude in the first few Myrs by the combined effects of dynamical friction and a drag force caused by tidally stripped stars. In fact, this is a significant speedup for equal mass ratio binaries, and becomes extreme for unequal mass ratios, e.g. 1:10 or 1:100, which traditional dynamical friction alone would not permit to bind. (ii) The subsequent binary hardening is driven by the gravitational slingshots between the SMBH binary and stars, and also depends on the mass ratio between the SMBHs. Thus, with this additional drag force, we find that all SMBHs in our suite coalesce within a Hubble time. Given that about 50 per cent of Milky Way-sized galaxies host NSCs, our results are encouraging for upcoming GW observations with the Laser Interferometer Space Antenna – LISA – which will detect SMBH coalescence in the 104–107 M⊙ mass range.
Evolutionary Analysis of the Bacillus subtilis Genome Reveals New Genes Involved in Sporulation
Authors: Shi Lei , Derouiche Abderahmane , Pandit Santosh , Rahimi Shadi , Kalantari Aida , Futo Momir , Ravikumar Vaishnavi , Jers Carsten , Mokkapati Venkata R S S , Vlahoviček Kristian , Mijakovic Ivan 
Published: February 2020

Abstract
Bacilli can form dormant, highly resistant, and metabolically inactive spores to cope with extreme environmental challenges. In this study, we examined the evolutionary age of Bacillus subtilis sporulation genes using the approach known as genomic phylostratigraphy. We found that B. subtilis sporulation genes cluster in several groups that emerged at distant evolutionary time-points, suggesting that the sporulation process underwent several stages of expansion. Next, we asked whether such evolutionary stratification of the genome could be used to predict involvement in sporulation of presently uncharacterized genes (y-genes). We individually inactivated a representative sample of uncharacterized genes that arose during the same evolutionary periods as the known sporulation genes and tested the resulting strains for sporulation phenotypes. Sporulation was significantly affected in 16 out of 37 (43%) tested strains. In addition to expanding the knowledge base on B. subtilis sporulation, our findings suggest that evolutionary age could be used to help with genome mining.
N
1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells
Authors: Parr Callum J C , Wada Shunsuke , Kotake Kenjiro , Kameda Shigetoshi , Matsuura Satoshi , Sakashita Souhei , Park Soyoung , Sugiyama Hiroshi , Kuang Yi , Saito Hirohide 
Published: February 2020

Abstract
Synthetic messenger RNA (mRNA) tools often use pseudouridine and 5-methyl cytidine as substitutions for uridine and cytidine to avoid the immune response and cytotoxicity induced by introducing mRNA into cells. However, the influence of base modifications on the functionality of the RNA tools is poorly understood. Here we show that synthetic mRNA switches containing N1-methylpseudouridine (m1Ψ) as a substitution of uridine substantially out-performed all other modified bases studied, exhibiting enhanced microRNA and protein sensitivity, better cell-type separation ability, and comparably low immune stimulation. We found that the observed phenomena stem from the high protein expression from m1Ψ containing mRNA and efficient translational repression in the presence of target microRNAs or proteins. In addition, synthetic gene circuits with m1Ψ significantly improve performance in cells. These findings indicate that synthetic mRNAs with m1Ψ modification have enormous potentials in the research and application of biofunctional RNA tools.
Depletion of erythropoietic miR-486-5p and miR-451a improves detectability of rare microRNAs in peripheral blood-derived small RNA sequencing libraries
Authors: Juzenas Simonas , Lindqvist Carl M , Ito Go , Dolshanskaya Yewgenia , Halfvarson Jonas , Franke Andre , Hemmrich-Stanisak Georg 
Published: February 2020

Abstract
Erythroid-specific miR-451a and miR-486-5p are two of the most dominant microRNAs (miRNAs) in human peripheral blood. In small RNA sequencing libraries, their overabundance reduces diversity as well as complexity and consequently causes negative effects such as missing detectability and inaccurate quantification of low abundant miRNAs. Here we present a simple, cost-effective and easy to implement hybridization-based method to deplete these two erythropoietic miRNAs from blood-derived RNA samples. By utilization of blocking oligonucleotides, this method provides a highly efficient and specific depletion of miR-486-5p and miR-451a, which leads to a considerable increase of measured expression as well as detectability of low abundant miRNA species. The blocking oligos are compatible with common 5′ ligation-dependent small RNA library preparation protocols, including commercially available kits, such as Illumina TruSeq and Perkin Elmer NEXTflex. Furthermore, the here described method and oligo design principle can be easily adapted to target many other miRNA molecules, depending on context and research question.
Resolution of post-adalimumab vitiligo with secukinumab in a patient with psoriasis vulgaris
Authors: Palazzo Giovanni 
Published: February 2020

Abstract
Plaque psoriasis is a chronic debilitating condition, and biologic agents that inhibit tumor necrosis factor-α (TNF-α) are widely employed in management of the condition. Notwithstanding, several paradoxical adverse reactions have been reported with TNF-α inhibitors, including vasculitis, vitiligo, alopecia areata, sarcoidosis and other granulomatous diseases. Herein, we report the case of a 63-year-old man who developed vitiligo while on therapy with adalimumab following failure of conventional agents for plaque psoriasis. After discontinuation of adalimumab and initiation of secukinumab, vitiligo and other psoriatic symptoms gradually resolved. After 1 year of treatment, only small plaque areas were present in the flexor site with complete remission in the extensor area along with near complete resolution of depigmented areas. In this case of possible adalimumab-induced vitiligo in a patient with plaque psoriasis, secukinumab resolved both the symptoms of psoriasis and the likely adalimumab-related vitiligo.
Transclival Approach for Resection of a Pontine Cavernous Malformation: 2-Dimensional Operative Video
Authors: London Dennis , Lieberman Seth , Tanweer Omar , Pacione Donato 
Published: February 2020

Abstract
Cerebral cavernous malformations are common vascular anomalies consisting of a cluster of capillaries without intervening brain tissue.
1
A variety of approaches for resection have been undertaken,
2
and a handful of case reports have described the endoscopic, endonasal, transclival approach.
3
We present a case of a 51-yr-old woman with lupus and hepatitis B-associated cirrhosis who presented with diplopia, dysphagia, and ataxia. She had a left abducens nerve palsy and magnetic resonance imaging (MRI) showed a left pontine cavernous malformation. After a repeat hemorrhage, she consented to surgical resection. The lesion appeared to come to the medial pontine pial surface. Tractography indicated a rightward displacement of the left corticospinal tract. Therefore, an endoscopic, transnasal, transclival approach was chosen. A lumbar drain was placed preoperatively. The clivus and ventral petrous bone were drilled using the vidian canal to help identify the anterior genu of the petrous carotid artery. The clival dura was opened, revealing the abducens nerve exiting the ventral pons. The cavernoma was visible on the surface lateral to the nerve. It was removed using blunt dissection and the remaining cavity inspected. The skull base was reconstructed using an abdominal dermal-fat graft and Alloderm covered by a nasoseptal flap. Postoperatively she had transient swallowing difficulty. The lumbar drain was kept open for 5 d. Cerebrospinal fluid (CSF) leak was ruled out using an intrathecal fluorescein injection. She was discharged home, but presented 2 wk postoperatively with aseptic meningitis, which was treated supportively. Postoperative imaging did not show residual cavernoma.
Exotic branes and mixed-symmetry potentials II: Duality rules and exceptional p-form gauge fields
Authors: Fernández-Melgarejo José J , Sakatani Yuho , Uehara Shozo 
Published: February 2020

Abstract
In $U$-duality-manifest formulations, supergravity fields are packaged into covariant objects such as the generalized metric and $p$-form fields $\mathcal A_p^{I_p}$. While a parameterization of the generalized metric in terms of supergravity fields is known for $U$-duality groups $E_n$ with $n\leq 8$, a parameterization of $\mathcal A_p^{I_p}$ has not been fully determined. In this paper, we propose a systematic method to determine the parameterization of $\mathcal A_p^{I_p}$, which necessarily involves mixed-symmetry potentials. We also show how to systematically obtain the $T$- and $S$-duality transformation rules of the mixed-symmetry potentials entering the multiplet. As the simplest non-trivial application, we find the parameterization and the duality rules associated with the dual graviton. Additionally, we show that the 1-form field $\mathcal A_1^{I_1}$ can be regarded as the generalized graviphoton in the exceptional spacetime.
Momentum and Reversals When Overconfident Investors Underestimate Their Competition
Authors: Luo Jiang , Subrahmanyam Avanidhar , Titman Sheridan 
Published: February 2020

Abstract
We develop a model in which overconfident investors overestimate their own signal quality but are skeptical of others’ Investors who are initially uninformed believe that early-informed investors have learned little, leading the former investors to provide excess liquidity, which, in turn, causes underreaction and short-run momentum. Skeptical investors can also react to stale information, causing momentum, followed by reversals. Hence, skepticism generates both momentum and reversals; the latter are amplified if investors overassess their own signal precision. We explain how long-run reversals can disappear while shorter-term momentum prevails, provide empirical implications, and link momentum to liquidity and price efficiency.
Does Circadian Rhythm Affect the Pharmacokinetics of Once-Daily Tobramycin in Adults With Cystic Fibrosis?
Authors: van Maarseveen Erik M. , van der Meer Renske , Neef Cees , Heijerman Harry G. M. , Touw Daniel J. 
Published: February 2020

Background:
In the era of multiple daily dosing of systemic aminoglycosides, a circadian rhythm in the clearance of these vital antibiotics has been demonstrated in animals and healthy volunteers. Over the past decade, once-daily dosing regimens have been proved to be less nephrotoxic and were therefore adopted worldwide for most indications requiring treatment with an aminoglycoside. In this study, the effect of the time of administration on the pharmacokinetics of once-daily tobramycin in adults with cystic fibrosis (CF) experiencing a pulmonary exacerbation was investigated.

Methods:
In this open randomized study, patients with CF received intravenous tobramycin at 8:00 or 22:00 hours. Pharmacokinetic and kidney function parameters were compared between the 2 groups.

Results:
Twenty-five patients were included. The mean weight-corrected clearances of tobramycin were 1.46 versus 1.43 mL/h*kg (P = 0.50) and mean volumes of distribution were 0.25 versus 0.27 L/kg (P = 0.54) for the 8:00 and 22:00 groups, respectively. In addition, no significant differences were detected in changes in estimated clearances of creatinine or tobramycin on day 1 and day 8 in the 8:00 or 22:00 group, indicating that there was no decline in clearance over time. At day 8 of therapy, the increase in serum blood urea nitrogen in the 22:00 group was significantly higher than that in the 8:00 group (1.8 versus 0.2 mmol/L, P = 0.015).

Conclusions:
The time of administration (8:00 versus 22:00) did not affect tobramycin pharmacokinetics in the adult CF population studied. The increase in serum blood urea nitrogen in the 22:00 group requires further investigation.
Positive affect and chronic pain: a preregistered systematic review and meta-analysis
Authors: Ong Anthony D. , Thoemmes Felix , Ratner Kaylin , Ghezzi-Kopel Kate , Reid M. Carrington 
Published: February 2020

AbstractChronic noncancer pain (CNCP) is a significant health burden among adults. Standard behavioral therapies typically focus on targeting negative affect (NA) and yield only modest treatment effects. The aims of this study were to systematically review and investigate the association between positive affect (PA) and pain severity among adults with CNCP. Databases that were searched included MEDLINE (PubMed), PsycINFO, CINAHL, ProQuest Dissertations and Theses, OLASTER, Open Grey, and PsyArXiv (inception to July 23, 2019). We analyzed studies that: (1) used observational, experimental, or intervention study designs; (2) enrolled individuals with CNCP (pain ≥ 12 weeks); and (3) reported full quantitative results on outcomes. Two researchers independently screened articles, extracted data, and assessed the risk of bias. The main meta-analysis was followed by subgroup analyses. All analyses were performed using random-effects models. Formal tests for heterogeneity (Q-statistic; I2) and publication bias (p-curve andp-uniform*) were performed. We meta-analyzed 29 studies with 3521 participants. Results demonstrated that PA inversely impacts pain severity in people with CNCP (r= −0.23). Subgroup analyses showed a significant effect for gender and marginally significant effects for age in studies that adjusted for NA. On average, effect sizes for observational studies were larger in studies with a higher proportion of female respondents and in studies that did not adjust for NA. Finally, larger effect sizes were found in intervention studies with older compared with younger samples.
Opioid Use Disorder and Employee Work Presenteeism, Absences, and Health Care Costs
Authors: Henke Rachel Mosher , Ellsworth David , Wier Lauren , Snowdon Jane 
Published: February 2020

Objective:
To measure the prevalence of opioid use disorder (OUD) and employee health care and productivity costs with and without OUD and to assess whether utilization of pharmacotherapy for OUD reduces those costs.

Methods:
We conducted a cross-sectional analysis of 2016 to 2017 commercial enrollment, health care, and pharmacy claims and health risk assessment data using the IBM® MarketScan® Databases (Ann Arbor, MI). We estimated regression models to assess the association between OUD and annual employee health care and productivity costs.

Results:
Health care and productivity costs for employees with OUD who did and did not receive pharmacotherapy were approximately $6294 and $21,570 more than for other employees, respectively.

Conclusions:
Employers can make a business case for expanding access to pharmacotherapy treatment for OUD based on our finding that receipt of pharmacotherapy significantly reduces overall health care costs.