bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress of genome editing technology and developmental biology useful for radiation research
Authors: Miura Kento , Ogura Atsuo , Kobatake Kohei , Honda Hiroaki , Kaminuma Osamu 
Published: December 2020

ABSTRACT
Following the development of genome editing technology, it has become more feasible to create genetically modified animals such as knockout (KO), knock-in, and point-mutated animals. The genome-edited animals are useful to investigate the roles of various functional genes in many fields of biological science including radiation research. Nevertheless, some researchers may experience difficulty in generating genome-edited animals, probably due to the requirement for equipment and techniques for embryo manipulation and handling. Furthermore, after obtaining F0 generation, genome-edited animals generally need to be expanded and maintained for analyzing the target gene function. To investigate genes essential for normal birth and growth, the generation of conditional KO (cKO) animals in which a tissue- or stage-specific gene mutation can be introduced is often required. Here, we describe the basic principle and application of genome editing technology including zinc-finger nuclease, transcription-activator-like effector nuclease, and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR associated protein (Cas) systems. Recently advanced developmental biology methods have enabled application of the technology, especially CRISPR/Cas, to zygotes, leading to the prompt production of genome-edited animals. For pre-implantation embryos, genome editing via oviductal nucleic acid delivery has been developed as an embryo manipulation- or handling-free method. Examining the gene function at F0 generation is becoming possible by employing triple-target CRISPR technology. This technology, in combination with a blastocyst complementation method enables investigation of even birth- and growth-responsible genes without establishing cKO strains. We hope that this review is helpful for understanding and expanding genome editing-related technology and for progressing radiation research.
Toward A Second Theology: Avant-Garde Art and Theopolitics
Authors: Carlsson Redell Petra 
Published: December 2020

Abstract
This article introduces the conceptual couple first theology and second theology as an answer to J. Kameron Carter’s call for a theopolitical approach beyond the proper practice versus malpractice dualism in Western political theology. In order to find sources to further renegotiate the relationship between the material, the spiritual and the political, the article turns East to Russian avant-garde artists and thinkers Liubov Popova (1889–1924) and Vladimir Tatlin (1885–1953), discussed in relation to Walter Benjamin (1892–1940). The conceptual couple according to which first theology is understood as theology is stuck in a representational logic where proper practice can be easily distinguished from malpractice. Second theology, on the other hand, is a performative approach to theology beyond the representational logic: theology that does and constructs rather than is and represents. Thus, second theology is theology that is political, even activist, without pertaining to truth claims or ideals regarding proper or improper theological practice.
Complex Ideas and Hume’s Separability Principle
Authors: Qu Hsueh M 
Published: December 2020

AbstractIn this paper, I will argue that a number of Hume’s claims generate a putative inconsistency with regard to complex ideas and independent existence. I first provide a prima facie argument for the existence of this inconsistency. Then, I examine a number of attempts to rescue Hume from this problem, and argue that each of them fails, before proposing my own solution.
Run or Die in the Evolution of New MicroRNAs—Testing the Red Queen Hypothesis on De Novo New Genes
Authors: Zhao Yixin , Lu Guang-An , Yang Hao , Lin Pei , Liufu Zhongqi , Tang Tian , Xu Jin 
Published: December 2020

Abstract
The Red Queen hypothesis depicts evolution as the continual struggle to adapt. According to this hypothesis, new genes, especially those originating from nongenic sequences (i.e., de novo genes), are eliminated unless they evolve continually in adaptation to a changing environment. Here, we analyze two Drosophila de novo miRNAs that are expressed in a testis-specific manner with very high rates of evolution in their DNA sequence. We knocked out these miRNAs in two sibling species and investigated their contributions to different fitness components. We observed that the fitness contributions of miR-975 in Drosophila simulans seem positive, in contrast to its neutral contributions in D. melanogaster, whereas miR-983 appears to have negative contributions in both species, as the fitness of the knockout mutant increases. As predicted by the Red Queen hypothesis, the fitness difference of these de novo miRNAs indicates their different fates.
Partisan Affective Polarization
Authors: Már Kristinn 
Published: December 2020

Abstract
Partisan affective polarization, measured with feeling thermometer ratings, has increased gradually in the United States over a long period. This article describes how affective polarization and its composite parts, rival-party and own-party feelings, have changed over time. It identifies three analytically distinct processes: sorting, which entails a change in group composition; entrenchment, or an increasing gap between aligned and misaligned copartisans; and fortification, a general change in party feelings across partisan subgroups. While scholars often emphasize the importance of sorting, a Blinder-Oaxaca decomposition analysis of ANES data shows that entrenchment and fortification explain a larger share of these thermometer trends. Furthermore, asymmetries between the two major parties exist: the lion’s share of colder rival-party feelings among Republicans is centered on race, while Democrats’ rival-party feelings grew similarly cold regardless of their race, religion, or ideological extremity. In addition, the gap in party feelings between well and poorly aligned Democrats appears to have decreased over time. Finally, data from two ANES panels suggest that the same partisans’ feelings are growing colder, not that partisans with warm rival-party feelings are switching parties. These findings have important implications for the study of affective polarization and suggest avenues for future research.
Multifactor Models and Their Consistency with the APT
Authors: Cooper Ilan , Ma Liang , Maio Paulo , Philip Dennis 
Published: December 2020

Abstract
We examine the consistency of several prominent multifactor models from the empirical asset pricing literature with the arbitrage pricing theory (APT) framework. We follow the APT-related literature and estimate the common factor structure from a rich cross-section (associated with 42 major CAPM anomalies) by employing the asymptotic principal components method. Our benchmark model contains six statistical factors and clearly dominates, in both economic and statistical terms, most of the empirical multifactor models proposed in the literature by a good margin. These results represent a critical challenge to the current workhorse models in terms of explaining large-scale equity risk premiums. (JEL G10, G12)
Received December 27, 2019; editorial decision October 20, 2020 by Editor Thierry Foucault. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Non-parametric Analysis of Time-Inconsistent Preferences
Authors: Blow Laura , Browning Martin , Crawford Ian 
Published: December 2020

AbstractThis article provides a revealed preference characterisation of quasi-hyperbolic discounting which is designed to be applied to readily available expenditure surveys. We describe necessary and sufficient conditions for the leading forms of the model and also study the consequences of the restrictions on preferences popularly used in empirical lifecycle consumption models. Using data from a household consumption panel dataset, we explore the prevalence of time-inconsistent behaviour. The quasi-hyperbolic model provides a significantly more successful account of behaviour than the alternatives considered. We estimate the joint distribution of time preferences and the distribution of discount functions at various time horizons.
Early Versus Late Preventive Ileostomy Closure Following Colorectal Surgery: Systematic Review and Meta-analysis With Trial Sequential Analysis of Randomized Controlled Trials
Authors: Cheng Zhiqiang , Dong Shuohui , Bi Dongsong , Wang Yanlei , Dai Yong , Zhang Xiang 
Published: December 2020

BACKGROUND:
Most preventive ileostomy following colorectal surgery requires a closure procedure. The intervals between primary surgery and ileostomy closure remain controversial.

OBJECTIVE:
This study aimed to compare early versus late closure of preventive ileostomy following colorectal surgery.

DATA SOURCE:
A systematic literature search was performed in conference papers, MEDLINE, EMBASE, the Cochrane Library, and the Clinicaltrials.gov database.

STUDY SELECTION:
Randomized clinical trials published through October 2019 comparing early versus late closure of ileostomy following colorectal surgery were selected.

MAIN OUTCOME MEASURES:
Morbidity, leak of the primary anastomosis, reoperation, surgical site infection, small-bowel obstruction/postoperative ileus, total operative time, and postoperative length of hospital stay were measured. Results were synthesized using meta-analysis and were rated as firm or weak evidence by trial sequential analysis.

RESULTS:
A total of 6 randomized controlled trials were included. Firm evidence from trial sequential analysis demonstrated that the early closure of ileostomy after colorectal surgery reduced the incidence of small-bowel obstruction/postoperative ileus and required less total operative time, but increased the incidence of surgical site infection, compared with late closure of ileostomy; postoperative length of hospital stay tended to be longer with early versus late closure of ileostomy. Weak evidence showed that there was no difference between early and late closure in morbidity, reoperation, or leak of the primary anastomosis.

LIMITATIONS:
The study was limited by some evidence rated as weak from trial sequential analysis, combined analysis of small-bowel obstruction and postoperative ileus, and exclusion of the influence of chemo- or radiotherapy.

CONCLUSIONS:
In selected patients, early closure of ileostomy after colorectal surgery can be considered, with a lower incidence of postoperative small-bowel obstruction/postoperative ileus and less total operative time, but a relatively high surgical site infection rate. PROSPERO registration number: CRD42020160989
Gastrointestinal Internal Fistulas in Crohn’s Disease
Authors: Egunsola Adekemi O. , Schwartzberg David M. 
Published: December 2020

Case Summary:
A 27-year-old man with fistulizing terminal ileal Crohn’s disease with an ileosigmoid fistula progressed through medical management and required an abdominal operation at an outside hospital. He underwent an ileocolic resection and a debridement with oversewing of his mesenteric sigmoid fistula with a diverting loop ileostomy. After a normal colonoscopy, his stoma was reversed; however, 2 weeks later he presented to the hospital with pelvic sepsis. A CT scan with oral, intravenous, and rectal contrast demonstrated a persistent sigmoid fistula with associated abscess. After treatment with antibiotics and percutaneous drainage, the patient underwent a segmental sigmoid resection to repair the mesenteric fistula and a diverting loop ileostomy. The ileostomy has been reversed and the patient’s Crohn’s disease is in remission.
ISOLATED MACULOPATHY AND MODERATE ROD–CONE DYSTROPHY REPRESENT THE MILDER END OF THE RDH12-RELATED RETINAL DYSTROPHY SPECTRUM
Authors: De Zaeytijd Julie , Van Cauwenbergh Caroline , De Bruyne Marieke , Van Heetvelde Mattias , De Baere Elfride , Coppieters Frauke , Leroy Bart P. 
Published: December 2020

Purpose:
To describe an isolated maculopathy and an intermediate rod–cone dystrophy phenotype as the milder end of the RDH12-related retinal dystrophy spectrum.

Methods:
Seven patients (17–34 years of age) underwent an extensive ophthalmic workup including psychophysical and electrophysiological testing and multimodal imaging.

Results:
Three patients have isolated macular disease. Best-corrected visual acuity (BCVA) ranges from 20/125 to 20/40 with normal visual fields or only limited central, relative scotomata, and normal full-field ERGs. Both optical coherence tomography scans and autofluorescent imaging hint at relatively better-preserved foveal quality initially. An intermediate rod–cone phenotype in four patients is characterized by a central retinal dystrophy extending just beyond the vascular arcades, characteristic peripapillary sparing, and additional scattered atrophic patches. Again, foveal quality is initially better on optical coherence tomography scans. Best-corrected visual acuity ranges from counting fingers to 20/32. Goldmann visual fields vary from central scotomata to severe generalized abnormalities. ERGs range between mild and severe rod–cone dysfunction. Nine distinct RDH12 pathogenic variants, two of which are novel, are identified.

Conclusion:
The classic phenotype of RDH12-related early-onset retinal dystrophy is expanded to include an isolated maculopathy and intermediate dystrophy phenotype, characterized by its later onset and milder course with a fair visual potential until much later in life, emphasizing the phenotypic heterogeneity of RDH12-related retinopathy.
ACUTE RETINAL NECROSIS
Authors: Botsford Benjamin W. , Nguyen Vincent Q. , Eller Andrew W. 
Published: December 2020

Purpose:
To investigate differences in outcomes of acute retinal necrosis with confirmed viral polymerase chain reaction between viral types and highlight different treatment options.

Methods:
The study evaluated 22 eyes in 18 patients of polymerase chain reaction-positive acute retinal necrosis at the University of Pittsburgh Medical Center from 2007 to 2018. Outcome measures included final visual acuity, treatment paradigms, and retinal detachment rate.

Results:
Eight eyes were polymerase chain reaction-positive for varicella zoster virus, two eyes for herpes simplex virus Type 1 (HSV-1), and 12 eyes for herpes simplex virus Type 2 (HSV-2). Final Snellen best-corrected visual acuity averaged 20/51 for varicella zoster virus, 20/25 for HSV-1, and 20/814 for HSV-2. Retinal detachment occurred in 2 (25%) of varicella zoster virus eyes and 8 (75%) of HSV-2 eyes. One eye with HSV-1 and three eyes with HSV-2 received cidofovir for treatment of refractory retinitis.

Conclusion:
Acute retinal necrosis secondary to HSV-2 tended to have persistent active retinitis with a higher rate of retinal detachment despite similar treatment protocols, suggesting that in some cases combination intravenous acyclovir and adjuvant intravitreal foscarnet injections are not sufficient. Despite the risk of renal toxicity, intravenous cidofovir may be a consideration in select patients.
Implantation of an iris-fixated phakic intraocular lens for the correction of hyperopia: 15-year follow-up
Authors: van Rijn Gwyneth A. , Gaurisankar Zoraida S. , Saxena Ruchi , Gibbes Destiny , Jongman Henri P. , Haasnoot Geert W. , Cheng Yanny Y. Y. , Beenakker Jan-Willem M. , Luyten Gregorius P.M. 
Published: December 2020

Purpose:
To assess the predictability, efficacy, stability, and safety of implantation of an Artisan iris-fixated phakic intraocular lens (IF-pIOL) for the correction of hyperopia with a follow-up of up to 15 years.

Setting:
Leiden University Medical Center, the Netherlands.

Methods:
Patients operated by a single surgeon up to 2007 were identified, and data on refraction, corrected distance visual acuity (CDVA), uncorrected distance visual acuity, endothelial cell (EC) density, and complications were collected.

Results:
A total of 61 eyes (32 patients) were analysed. The mean spherical equivalent decreased from +6.43 ± 1.78 diopters (D) preimplantation to −0.22 ± 0.57 D at 1 year postimplantation and remained stable throughout follow-up. A stable CDVA with safety indices ranging from 0.91 to 1.10 and efficacy indices between 0.43 and 0.86 were observed. Follow-up time had a significant effect on EC density with an estimated annual decline of 58 cells/mm2 after IF-pIOL implantation. IF-pIOL explantation was performed in a 10 eyes (16.4%) after 8.13 ± 5.11 years. The main reason for IF-pIOL explantation was EC loss (4 eyes [6.6%]). Pigment dispersion was the most encountered complication, observed in 9 eyes (14.8%).

Conclusions:
Visual and refractive results after implantation of an IF-pIOL to correct hyperopia show favorable and stable results with long-term follow-up. Lifelong monitoring of EC counts is mandatory. Pigment dispersion might be a problem in hyperopic eyes implanted with an IF-pIOL; a shallower anterior chamber depth and a convex iris configuration might be predisposing factors.
A Mixed Methods, Observational Investigation of Physical Activity, Exercise, and Diet Among Older Ugandans Living With and Without Chronic HIV Infection
Authors: Wright Chelsea H. , Longenecker Chris T. , Nazzindah Rashidah , Kityo Cissy , Najjuuko Theresa , Taylor Kirsten , Rentrope Cynthia Robin , Webel Allison 
Published: December 2020

Abstract
People living with HIV (PLWH) are at increased risk for cardiovascular disease. Physical activity, exercise, and controlled diet can mitigate this risk, yet these behaviors are understudied in sub-Saharan Africa. Our objective was to describe and compare the meaning, value, and patterns of physical activity, exercise, and diet among PLWH and older adults without HIV in Uganda. This mixed methods, observational study included 30 adult PLWH and 29 adults without HIV who (a) wore an accelerometer to measure physical activity; (b) had weight, height, and waist and hip circumference measured; (c) completed physical fitness measures; and (d) used digital cameras to record photographs and videos of their typical diet and physical activities. Participants were approximately 58 years old and 68% female. Approximately 20% of PLWH and 40% of adults without HIV met physical activity guidelines (p > .05). Qualitative themes included engaging in a variety of exercise, structural barriers to exercising, and typical meals. Older adults in Uganda have low levels of physical activity and homogenous diets, increasing their risk for cardiovascular disease.
Cryptococcosis caused by cryptococcus gattii
Authors: Xue Xinying , Deng Hui , Zhao Longting , Zang Xuelei , Asuquo Idorenyin Polycarp , Meng Mingming , Ma Xidong , Qin Chong , Meng Yao , Wu Chongchong , Gao Jie , Pan Lei 
Published: December 2020

Abstract
Cryptococcosis caused by Cryptococcus gattii, is a life threatening fungal infection with recently increasing prevalence. C. gattii is a species complex comprising multiple independent species. However, many biological characteristics and clinical features of cryptococcosis due to C. gattii are relatively less well defined. In this paper, we identify two cases of C. gattii infection, and laboratory findings of genotype VGI and VGII in two groups of apparently immunocompetent Chinese individuals respectively. Upon detailed review of all 35 cases of C. gattii infections, it was observed that C. gattii can cause debilitating illness in both immunocompetent and immunocompromised individuals. Cryptococcosis due to C. gattii is a serious systemic fungal infection, with pulmonary central nervous system tropism. Epidemiologically, C. gattii infection is not only restricted in tropical and subtropical regions, but also in other geographical settings.
The effectiveness and safety of acupuncture for scoliosis
Authors: Choi Seong-Kyeong , Jo Hyo-Rim , Park Seo-Hyun , Sung Won-Suk , Keum Dong-Ho , Kim Eun-Jung 
Published: December 2020

Abstract

Background:
Scoliosis is a disease that affects all age groups and alters the three-dimensional deviation of the spinal axis. It is diagnosed when Cobb angle presents over 10 degrees and the reasons include aging, traumatic injuries, unknown origin, and disorders of congenital, neurological, musculoskeletal, and connective tissue. Scoliosis treatments are divided into surgical and conservative options. Surgery can correct the curved spine but has associated risks and economic burden. Conservative treatments, particularly bracing, prevent the progression of scoliosis, but still remains potential ingredient of curvation and patients poor compliance. Recent studies reported that various types of acupuncture can improve the curvation and the associated pain. However, there has been no systematic review on this issue. Therefore, this study will review the effectiveness and safety of acupuncture on scoliosis.

Methods:
Searching randomized controlled trials about the use of acupuncture for scoliosis will be performed using multiple electronic databases, manual search, and contact to authors e-mail if needed. We will select studies by the pre-defined criteria and summarize the data on study participants, interventions, control groups, outcome measurement, adverse events, and risk of bias. The primary outcome will be the Cobb angle, which is objective, and the secondary outcomes are associated with patient-centered indices (pain, functional status, and quality of life), which are subjective and adverse events. We will use Review Manager software (Version 5.3; Copenhagen; The Nordic Cochrane Center, The Cochrane Collaboration, 2014) to perform a meta-analysis and Cochrane Collaboration “risk of bias” tools to assess the risk of bias.

Results:
Our study will investigate the clinical evidence on the effectiveness and safety of acupuncture on scoliosis.

Conclusion:
Our study will be informative to scoliosis patients, clinicians, policy makers, and researchers working with conservative management for scoliosis.