bluuebunny/crossref_metadata_2025_split huggingface dataset:
D‐π‐A Molecular Probe to Unveil the Role of Solute‐Solvent Hydrogen Bonding in Solvatochromism, Location Specific Preferential Solvation and Synergistic Effect in Binary Mixtures
Authors: Kumar Malik Prakash , Tripathy Madhusmita , Patel Sabita 
Published: March 2020

AbstractAn azo dye 4‐(p‐Nitrophenylazo) phenol (NPAP) characterized with a donor‐π‐acceptor (D‐π‐A) framework has been used as a molecular probe to study solvatochromic behavior in neat and binary solvent mixtures comprised of chloroform (a hydrogen bond donor; HBD solvent) and a hydrogen bond acceptor (HBA) solvent. The specificity of the probe lies in its inherent characteristics of having a HBD group and a HBA group at two different ends of the conjugated π‐network. UV‐Vis spectroscopic technique is used for the purpose. The probe demonstrates a very expressive reversal in solvatochromic behavior, with the solvatochromic switch at ET(30) of ∼45 kcal mol−1. Multiparametric treatment of the solvatochromic data using SEV technique displays excellent sensitivity of the probe towards HBA basicity, dipolarity and polarizability of the medium with a smaller but significant contribution from HBD acidity and hydrophobicity/apolarity. The event of preferential solvation in the chloroform‐HBA mixture is explained on the basis of specific solute‐solvent interaction through HBD and HBA ability of the solvent components. HBA solvents preferentially solvate the phenolic site while HBD solvents preferentially solvate the nitrobenzene group through complementary hydrogen bonding, which results in an increase in local concentration at specific sites resulting in synergistic preferential solvation. The proposition of site selective PS through molecular recognition is also supported by theoretical studies.
An Electropolymerized Molecularly Imprinted Electrochemical Sensor for the Selective Determination of Bisphenol A Diglycidyl Ether
Authors: Li Jiayong , Ma Ya , Zeng Qiang , Wang Min , Wang Lishi 
Published: March 2020

AbstractIn this manuscript, a sensitive and selective molecular imprinted electrochemical sensor for the detection of bisphenol A diglycidyl ether (BADGE) in canned oil was developed. Using BADGE as template, pyrrole as functional monomer, after electropolymerization and elution processes, the molecular imprinted film for the special recognition of BADGE was prepared on the surface of platinum disk electrode. Every step in the experiment was verified by field emission scanning electron microscope (SEM), microscopic fourier transform infrared spectroscopy (Micro‐FTIR), cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The experimental parameters in the assay were optimized, and the linear range of the MIP sensor was 0.05 μmol dm−3 to 10 μmol dm−3 with the detection limit of 0.04 μmol dm−3 based on S/N=3. The sensor was applied to edible oil samples for detection with a good accuracy, which could be used as a new strategy for sensitive, rapid, simple and cost‐effective screening of BADGE.
Synthesis of Bis(trimethylsilyl)acetylene (BTMSA) by Direct Reaction of CaC2 with N‐(trimethylsilyl)imidazole
Authors: Liu Shuaishuai , Yin Shuai , Zhang Zhaofu , Liu Huizhen , Liu Mingyang , Han Buxing 
Published: March 2020

AbstractIn this work, we discovered that bis(trimethylsilyl)acetylene (BTMSA) could be synthesized by the reaction of calcium carbide (CaC2) directly with N‐(trimethylsilyl)imidazole (TMSIm) in dichloromethane using CuBr as the catalyst, and reaction could occur efficiently at 100 °C. Control experiment indicated that the reaction did not proceed via acetylene pathway. As far as we know, this is the first work for BTMSA synthesis by direct reaction of CaC2 and a silylation reagent under mild conditions.
Multicomponent Reaction of Pyridinium Salts, β‐Nitrostyrenes and Ammonium Acetate under the DBU/Acetic Acid System: Access to 2,4,6‐Triarylpyridine Derivatives
Authors: Li Mingshuang , Wang Ting , Wang Cunde 
Published: March 2020

AbstractA four‐component reaction of pyridinium salts, substituted β‐nitrostyrenes and ammonium acetate as a nitrogen source using acetic acid as solvent was investigated to develop an efficient divergent route for the synthesis of 2,4,6‐trisubstituted pyridines. This efficient method provides fast access to a variety of structurally diverse pyridine derivatives. The structure of a typical product was confirmed by X‐ray crystallography.
Peptide‐Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate
Authors: Añón Elena , Costero Ana M. , Amorós Pedro , El Haskouri Jamal , Martínez‐Mánez Ramón , Parra Margarita , Gil Salvador , Gaviña Pablo , Terencio M. Carmen , Alfonso María 
Published: March 2020

AbstractOsteoporosis is an illness which appears when the osteoblast/osteoclast activities are unbalanced taking place bone resorption (caused by osteoclasts) in higher extension than bone formation (induced by osteoblasts). Alendronate is one of the most used drugs for osteoporosis treatment despite its scarce bioavailability. Here we present the synthesis and characterization of mesoporous gated nanoparticles (two sets) for the controlled release of alendronate. The first set of nanoparticles (S1) were loaded with sulforhodamine B and capped with a peptide that could be selectively hydrolyzed by cathepsin K enzyme (overexpressed in osteoclasts). The second set (S2) was functionalized with aminopropyl moieties, loaded with nitrobenzofurazan labelled alendronate and capped with the same peptide. Both nanoparticles were internalized by RAW 264.7 macrophages (which could differentiate in osteoclasts) and were able to release its entrapped cargo in the presence of cathepsin K added in the macrophage lysates. Using S2 nanoparticles 4.2% of the total alendronate amount in contact with the cells is liberated inside them and could produce its therapeutic effect.
One‐Pot Synthesis of Densely Substituted 1,2,3,4‐Tetrahydro‐1,6‐naphthyridine Mediated by Isocyanide‐Assisted Reduction of C−C Double Bond
Authors: Das Paramita , Ray Suman , Saha Rupak , Mukhopadhyay Chhanda 
Published: March 2020

AbstractMolecular architectures possessing the combination of heteroaromatic and saturated N‐heterocycles are of great importance because of their higher solubility in the gastrointestinal tract due to weak crystal packing in the three‐dimensional structure. Other biological activity like selectivity is also increased in a positive way. However, compared to fully aromatic fused heterocycles, synthesis of partially saturated fused heterocycles is much more difficult since the later needs greater control over the reaction conditions. In this context, 1,2,3,4‐tetrahydronaphthyridines (THNADs) are essential part of pharmaceutically important natural products and drug molecules. However, the synthesis of THNAD is seldom reported in literature. To the best of our knowledge, this is the first report of metal‐free one pot synthesis of 1,2,3,4‐tetrahydro‐1,6‐naphthyridines without starting from any nitrogen heterocycles in water. Moreover, this study discloses the involvement of isocyanide in a chemical reaction whose net effect is only to reduce a C=C bond which is unusual in isocyanide literature.
Batch and Column Arsenate Sorption Using Turbinaria ornata Seaweed Derived Biochar: Experimental Studies and Mathematical Modeling
Authors: Saravanakumar Krishnan , Senthilkumar Ramalingham , Prasad Donipathi Mogili Reddy , Prasad Balakrishna Sankari Naveen , Manickam Sathyamoorthy , Gajendiran Vasu 
Published: March 2020

AbstractThe ability of Turbinaria ornata seaweed derived biochar (TOB) to remove arsenate ions from polluted solutions in batch and column trials has been investigated. The biochar, produced at 300 °C and 120 min through pyrolysis, exhibited maximum arsenate sorption capacity at pH 4. Batch sorption isotherm was described with different models (Freundlich, Langmuir and Sips) and the Sips model best described the experimentally derived isotherm with high correlation coefficient and low percentage error values. The maximum arsenate sorptional capacity calculated using the Langmuir model was estimated to be 0.124 mmol/g (at pH 4; 2 g/L biochar dosage and 0.5 mmol/L initial arsenate concentration). For elution trials, 0.01 M NaOH performed well to desorb arsenate from arsenate‐bounded TOB with elution efficiency greater than 99.6% with no significant damage to TOB. The capability of TOB to sorb arsenate continuously was examined in a packed column. The continuous trials were mainly performed to evaluate the impact of influential column parameters including bed height, initial arsenate concentration and flow rate. The arsenate sorptional capacity declined with improvement in flow rate, whereas enhanced with increment in bed depth and initial arsenate concentration values. Regeneration of exhausted TOB was possible with 0.01 M NaOH. After three sorption‐elution cycles it was determined that TOB exhibited superior sorption capacities and percentage removal efficiencies.
From proprietary to collective governance: How do platform participation strategies evolve?
Authors: O'Mahony Siobhan , Karp Rebecca 
Published: March 2020

AbstractResearch SummaryWhen platform leaders change the rules guiding who can access and control a platform, the strategies of those who create value from the platform can be upended. Little research examines how platform participants adapt their strategies when a platform leader changes the rules governing access and control. We trace how participation with a development platform evolved under four different governance modes with varied access and control conditions. Participation intensity increased as access opened but decreased when platform leadership became unclear. Distributed platform leadership emerged only once the platform was collectively governed. Rather than assume that all firm participation complements a platform, we show how firms guardedly participate with open and collective platforms in ways that can either extend or subvert a platform's vitality.Managerial SummaryAs firms consider transitioning proprietary products to more open platforms to grow market share and relevance, we suggest that managers consider the concerns of external participants when designing a system to govern a platform. Opening access to a platform alone may be insufficient to stimulate external participants to contribute and make real commitments. Our research shows that open access did not stimulate external participation when platform leadership was not clear. When a structured but collectively determined development and governance process was created, external participants increased their contributions and even took on project leadership roles—distributing leadership of the platform among many firms.
Portfolio configuration and foreign entry decisions: A juxtaposition of real options and risk diversification theories
Authors: Belderbos René , Tong Tony W. , Wu Shubin 
Published: March 2020

AbstractResearch SummaryResearch on foreign market entry has rarely considered that multinational firms' new entries may be affected by the configuration of their existing affiliates. We argue that in making entry decisions, firms take into account how an entry into a new location helps increase the operational flexibility of their affiliate portfolios due to options to switch operations across affiliates in case of diverging labor cost developments across host countries. We juxtapose this real options‐based explanation with a risk diversification explanation. Analysis of Japanese multinational firms' foreign entry decisions suggests that the two explanations are complementary. We also establish portfolio‐level boundary conditions to the influence of operational flexibility considerations on entry, in the form of product diversification and the nature of dispersion of labor cost levels.Managerial SummaryWhen deciding on whether to enter a foreign market, managers of a multinational firm are intuitively aware that they need to consider how the economic environment of the target host country is related to the environments of the existing countries in which the firm operates. The less the environments are correlated with each other, whether in terms of input cost or market demand conditions, the greater the chance that the firm may capture cost savings and reduce sales volatility globally. These benefits arise from a switching option to shift operations flexibly across countries and from an ability to reduce risk by holding a portfolio of diversified global investments. Our findings support both sets of considerations, suggesting that companies do give due attention to correlations in labor cost and market demand between the target host country to enter and the existing host countries.
Experimental study on the seismic performance of novel precast reinforced concrete grid moment‐resisting frames
Authors: Fan Jia‐jun , Wu Gang , Xu Ao‐lin , Feng De‐cheng , Chen Zhi‐peng 
Published: March 2020

AbstractA new structure named reinforced concrete grid moment‐resisting frame (RC‐GMRF) have been adopted in high‐rise buildings in China. However, complex construction due to numerous beam‐column joints restricts the application of this structure. A novel precast reinforced concrete GMRF (PC‐GMRF) is proposed in this paper to solve this problem. Three specimens, including one traditional reinforced concrete moment‐resisting frame (RC‐MRF) as reference, were tested under reverse cyclic loading to evaluate the seismic performance. All three specimens were designed using the same amount of construction material. The experimental results showed that PC‐GMRF exhibited comparable seismic performance with that of RC‐GMRF. The load‐carrying capacity, initial stiffness and energy dissipation capacity were improved by an average of 43%, 29%, and 21%, respectively, compared with those of RC‐MRF. This study indicated that the performance of PC‐GMRF was acceptable and could be used in the moment‐resisting frame as a novel structure.
Transforming Candida hispaniensis, a promising oleaginous and flavogenic yeast
Authors: Morin Nicolas , Czerwiec Quentin , Nicaud Jean‐Marc , Neuvéglise Cécile , Rossignol Tristan 
Published: March 2020

AbstractCandida hispaniensis is an oleaginous yeast with a great potential for production of single cell oil according to its naturally high lipid accumulation capacity. Its unusual small genome size trait is also attractive for fundamental research on genome evolution. Our physiological study suggests a great potential for lipid production, reaching 224 mg/g of cell dry weight in glucose minimum medium. C. hispaniensis is also able to secrete up to 34.6 mg/L of riboflavin promising further riboflavin production improvements by cultivation optimization and genetic engineering. However, while its genome sequence has been released very recently, no genetic tools have been described up to now for this yeast limiting its use for fundamental research and for exploitation in an industrial biotechnology. We report here the first genetic modification of C. hispaniensis by introducing a heterologous invertase allowing the growth on sucrose using a biolistic transformation approach using a dedicated vector.The first genetic tool and transformation method developed here appear as a proof of concept, and while it would benefit from further optimization, heterogeneous expression of invertase allows for metabolism of an additional sugar and shows heterologous enzyme production capacity.
Introduction
Authors: Echeverría Gabriel 
Published: March 2020

AbstractIrregularity is a juridical status that describes the relation between a migrant and one or more states. As a social phenomenon, it does not derive from the migrations themselves, rather, it is the result “of the existence of a structural tension between the social preconditions and the political preconditions” that support them (Sciortino, 2007). The social space, following this interpretation, is the scenario where two different and opposed logics interact. On the one hand, there is the logic of free movement of people and goods that is favoured by socio-economic forces like the market-economy, globalization or transnationalism. On the other hand, there is the logic of the states, political-juridical constructions, historically and ideologically differentiated, that claim the power to delimit the space and to regulate the movement of factors across it. Irregularity would then be the result of the clash between these two logics that determine a numerical difference between the migrants that move across the geographical space, established by the first logic, and the migrants who are allowed to do that, established by the second logic.
Exotic spin-dependent forces from a hidden sector
Authors: Costantino Alexandria , Fichet Sylvain , Tanedo Philip 
Published: March 2020

Abstract
New dynamics from hidden sectors may manifest as long-range forces between visible matter particles. The well-known case of Yukawa-like potentials occurs via the exchange of a single virtual particle. However, more exotic behavior is also possible. We present three classes of exotic potentials that are generated by relativistic theories: (i) quantum forces from the loop-level exchange of two virtual particles, (ii) conformal forces from a conformal sector, and (iii) emergent forces from degrees of freedom that only exist in the infrared regime of the theory. We discuss the complementarity of spin-dependent force searches in an effective field theory framework. We identify well-motivated directions to search for exotic spin-dependent forces.
A note on $$\varvec{H^1-BMO}$$ duality
Authors: Osękowski Adam 
Published: March 2020

AbstractWe establish an estimate related to the$$H^1-BMO$$H1-BMOduality in the dyadic setting. Specifically, for any Hilbert space$${\mathcal {H}}$$Hover$${\mathbb {R}}$$Rand any functions$$\varphi ,\,\psi :{\mathbb {R}}\rightarrow {\mathcal {H}}$$φ,ψ:R→H, we have$$\begin{aligned} \mathop {\int }\limits _{{\mathbb {R}}} \varphi \cdot \psi \,\text{ d }u\le \sqrt{2}\Vert \varphi \Vert _{H^1}\Vert \psi \Vert _{BMO}. \end{aligned}$$∫Rφ·ψdu≤2‖φ‖H1‖ψ‖BMO.The constant$$\sqrt{2}$$2is the best possible. The proof rests on the existence of a certain special function enjoying appropriate size and concavity requirements.
Antimicrobial activity of goat’s milk fermented by single strain of kefir grain microflora
Authors: Biadała Agata , Szablewski Tomasz , Lasik-Kurdyś Małgorzata , Cegielska-Radziejewska Renata 
Published: March 2020

AbstractThe aim of the study was to assess the antibacterial properties of bioactive compounds released during the fermentation of goat’s milk by selected bacterial strains that are part of the kefir grain microflora. The material used in the experiments was kefir grain microflora (Lactobacillus kefiranofaciens subsp. kefirgranum DSM 10550, Lactobacillus kefiri PCM 2501, Lactobacillus parakefiri DSM 10551, Lactobacillus brevis PCM 488, Lactobacillus delbrueckii subsp. lactis PCM 2611), goat’s and cow’s milk and whey from these kinds of milk. The antimicrobial activity was tested against E. coli, Salmonella, Micrococcus luteus and Proteus mirabilis. Based on the experiments, it was found that during the fermentation of whey and goat's milk, bioactive substances were released, which inhibit the growth of indicator microorganisms by up to 8 logarithmic cycles.
Correction to: Physical evaluation of an ultra-high-resolution CT scanner
Authors: Oostveen Luuk J. , Boedeker Kirsten L. , Brink Monique , Prokop Mathias , de Lange Frank , Sechopoulos Ioannis 
Published: March 2020

The original version of this article, published on 10 February 2019, unfortunately contained a mistake. The axes of the graphs in Fig. 3 are incorrect. The correct figure is given below. Therefore, the last two sentences in “Results,” section “Noise,” should read: “The peak frequency of the HR and SHR was 0.21 lp/mm. For the NR mode and the MDCT, the peak frequencies were 0.17 lp/mm and 0.21 lp/mm, respectively.”
Heart rate variability as a measure of mental stress in surgery: a systematic review
Authors: The Anne-Fleur , Reijmerink Iris , van der Laan Maarten , Cnossen Fokie 
Published: March 2020

Abstract
Purpose
There is increasing interest in the use of heart rate variability (HRV) as an objective measurement of mental stress in the surgical setting. To identify areas of improvement, the aim of our study was to review current use of HRV measurements in the surgical setting, evaluate the different methods used for the analysis of HRV, and to assess whether HRV is being measured correctly.

Methods
A systematic review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). 17 studies regarding HRV as a measurement of mental stress in the surgical setting were included and analysed.

Results
24% of the studies performed long-term measurements (24 h and longer) to assess the long-term effects of and recovery from mental stress. In 24% of the studies, artefact correction took place.

Conclusions
HRV showed to be a good objective assessment method of stress induced in the workplace environment: it was able to pinpoint stressors during operations, determine which operating techniques induced most stress for surgeons, and indicate differences in stress levels between performing and assisting surgery. For future research, this review recommends using singular guidelines to standardize research, and performing artefact correction. This will improve further evaluation of the long-term effects of mental stress and its recovery.
Local, semi-automatic, three-dimensional liver reconstruction or external provider? An analysis of performance and time expense
Authors: Paschold Markus , Huettl Florentine , Kneist Werner , Boedecker Christian , Poplawski Alicia , Huber Tobias , Lang Hauke 
Published: March 2020

Abstract
Purpose
In hepatobiliary surgery, preoperative three-dimensional reconstruction based on CT or MRI can be provided externally or by local, semi-automatic software. We analyzed the time expense and quality of external versus local three-dimensional reconstructions.

Methods
Three first-year residents reconstructed data from 20 patients with liver pathologies using a local, semi-automatic, server-based program. Initially, five randomly selected patient datasets were segmented, with the visualization of an established external company available for comparison at all times (learning phase). The other fifteen cases were compared with the external datasets after completing local reconstruction (control phase). Total time expense/case and for specific manual and semi-automated reconstruction steps were recorded. Segmentation quality was analyzed by testing the equivalence for liver and tumor volumes, portal vein sectors, and hepatic vein territories.

Results
The median total reconstruction time was reduced from 2.5 h (learning phase) to 1.5 h (control phase) (− 42%; p < 0.001). Comparing the total and detailed liver volumes (sectors and territories) as well as the tumor volumes in the control phase equivalence was proven. In addition, a highly significant correlation between the external and local analysis was obtained over all analyzed segments with a very high ICC (median [IQR]: 0.98 [0.97; 0.99]; p < 0.01).

Conclusion
Local, semi-automatic reconstruction performed by inexperienced residents was feasible with an expert level time expense and the quality of the three-dimensional images was comparable with those from an external provider.