bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Cascade Biocatalysis for Deracemization of Racemic β‐Amino Alcohols to Enantiopure (S)‐β‐Amino Alcohols by Employing Cyclohexylamine Oxidase and ω‐Transaminase
Authors: Zhang Jian‐Dong , Chang Ya‐Wen , Dong Rui , Yang Xiao‐Xiao , Gao Li‐Li , Li Jing , Huang Shuang‐Ping , Guo Xing‐Mei , Zhang Chao‐Feng , Chang Hong‐Hong 
Published: August 2020

AbstractOptically active β‐amino alcohols are very useful chiral intermediates frequently used in the preparation of pharmaceutically active substances. Here, a novel cyclohexylamine oxidase (ArCHAO) was identified from the genome sequence of Arthrobacter sp. TYUT010‐15 with the R‐stereoselective deamination activity of β‐amino alcohol. ArCHAO was cloned and successfully expressed in E. coli BL21, purified and characterized. Substrate‐specific analysis revealed that ArCHAO has high activity (4.15 to 6.34 U mg−1 protein) and excellent enantioselectivity toward the tested β‐amino alcohols. By using purified ArCHAO, a wide range of racemic β‐amino alcohols were resolved, (S)‐β‐amino alcohols were obtained in >99 % ee. Deracemization of racemic β‐amino alcohols was conducted by ArCHAO‐catalyzed enantioselective deamination and transaminase‐catalyzed enantioselective amination to afford (S)‐β‐amino alcohols in excellent conversion (78–94 %) and enantiomeric excess (>99 %). Preparative‐scale deracemization was carried out with 50 mM (6.859 g L−1) racemic 2‐amino‐2‐phenylethanol, (S)‐2‐amino‐2‐phenylethanol was obtained in 75 % isolated yield and >99 % ee.
Filling the Transfer Advising Gap Through a Collaborative Partnership
Authors: Carlsen Paula K. , Gangeness Jeanine E. 
Published: August 2020

AbstractThis chapter describes a strong partnership with a long history between Rochester Community and Technical College (RCTC) and Winona State University (WSU), and focuses on the advising process utilized by a shared advisor employed by both institutions that has resulted in an improved transfer experience for students.
Midterm outcomes after the rescue THV‐in‐THV procedure: Insights from the multicenter prospective OCEAN‐TAVI registry
Authors: Hibino Makoto , Tabata Minoru , Ito Joji , Shibayama Kentaro , Obunai Kotaro , Watanabe Hiroyuki , Tada Norio , Naganuma Toru , Araki Motoharu , Yamanaka Futoshi , Ueno Hiroshi , Mizutani Kazuki , Higashimori Akihiro , Takagi Kensuke , Watanabe Yusuke , Shirai Shinichi , Yamamoto Masanori , Hayashida Kentaro 
Published: August 2020

AbstractObjectivesTo confirm whether the rescue transcatheter heart valve in the transcatheter heart valve (THV‐in‐THV) procedure is effective and feasible, we aimed to assess the midterm outcomes following rescue THV‐in‐THV procedures. The trends in the usage of the rescue THV‐in‐THV procedure at the time of transcatheter aortic valve implantation (TAVI) have also been explored.BackgroundMidterm outcomes of the rescue THV‐in‐THV procedure have been poorly defined, though it is popular as an effective method to bail‐out some complications in TAVI.MethodsWe reviewed data from the Optimized transCathEter vAlvular iNtervention‐Transcatheter Aortic Valve Implantation (OCEAN‐TAVI) registry and compared the outcomes of TAVI with rescue THV‐in‐THV and TAVI without rescue THV‐in‐THV. We also examined the annual rates of rescue THV‐in‐THV procedures in all the TAVI procedures between 2013 and 2017.ResultsAmong 2,588 patients who underwent TAVI, 26 patients have required rescue THV‐in‐THV for valve malposition (n = 23) or severe transvalvular regurgitation because of stuck THV leaflets (n = 3). Three cases needed an open conversion, and two died in the hospital. The rates of new permanent pacemaker implantation, acute kidney injury, and stroke were higher in the THV‐in‐THV group. A two‐year cumulative survival and echocardiographic outcomes succeeding rescue THV‐in‐THV procedure were comparable to non‐THV‐in‐THV cases. The rate of rescue THV‐in‐THV procedure lessened from 2.6% in 2013 to 0.6% in 2017.ConclusionsThe rescue THV‐in‐THV procedure is an effective and feasible option for THV malpositioning and stuck valve. It has given a comparable survival and a stable valve function over midterm observation periods.
Morphological assessments of deficient posterior‐inferior rim for transcatheter closure of atrial septal defect
Authors: Takaya Yoichi , Akagi Teiji , Nakagawa Koji , Nakayama Rie , Miki Takashi , Toh Norihisa , Ito Hiroshi 
Published: August 2020

AbstractObjectivesThis study aimed to determine morphological characteristics of deficient posterior‐inferior rim for transcatheter atrial septal defect (ASD) closure success.BackgroundThe feasibility of transcatheter closure of ASD with deficient posterior‐inferior rim remains unclear.MethodsOf 869 patients with ASD who were scheduled transcatheter closure, 121 with posterior‐inferior rim of <5 mm were included. Posterior‐inferior rim morphologies were evaluated by transesophageal echocardiography.ResultsOne hundred six patients successfully underwent transcatheter closure, while 15 patients failed. These 15 patients had complete deficient posterior‐inferior rim of 0 mm and/or a large defect of ≥38 mm. Multivariate logistic regression analysis showed that transcatheter closure failure was independently related to complete deficient posterior‐inferior rim and a large defect of ≥38 mm. Incomplete deficient posterior‐inferior rim of >0 to <5 mm was observed in 84 patients. All these patients successfully underwent transcatheter closure, except two patients with a large defect of ≥38 mm. Complete deficient posterior‐inferior rim was observed in 37 patients. The frequency of complete deficient posterior‐inferior rim was higher in patients who failed transcatheter closure (87% vs. 23%, p < .01), but transcatheter closure was performed successfully if the range of complete deficient rim was ≤30°. After the procedure, no adverse events occurred during a median follow‐up of 24 months.ConclusionsMost patients with deficient posterior‐inferior rim successfully underwent transcatheter closure. Transcatheter closure could be performed even in patients with complete deficient posterior‐inferior rim if the range was partial. Our findings can help to identify candidates for transcatheter closure.
Clinical characteristics and in hospital outcomes of heart transplant recipients undergoing percutaneous coronary intervention: Insights from the National Inpatient Sample
Authors: Shah Harshil , Patel Shakumar , Solanki Shantanu , Wudexi Ivan , Singh Jagmeet , Mullangi Sanjana , Shah Priyal , Sarker Khadiza , Shah Chail , Patel Achint 
Published: August 2020

AbstractObjectivesCardiac transplant patients are at increased risk of Coronary Allograft Vasculopathy which requires percutaneous coronary intervention (PCI).BackgroundWe aim to determine national epidemiology describing trends, mortality, and morbidity risks in patients with heart transplant undergoing PCI.MethodsWe used Nationwide Inpatient Sample (NIS) data from 2002 to 2014 to identify adult hospitalizations with PCI using ICD 9 codes. Acute myocardial infarction (AMI), cardiac transplant status and complications were identified using validated ICD‐9‐CM diagnosis codes. Endpoints were in‐hospital mortality and peri‐procedural complications. Propensity match analysis was performed to compare the end‐points between DES and BMS.ResultsTotal 8,613,900 patients underwent PCI, of which 1,531(0.002%) patients had prior heart transplant status. Among these 1,531 PCIs, 311(20%) were due to AMI including 125(8%) due to STEMI. 74% of PCIs were done in males and 78% of the PCIs were performed in the 60–79 age group. Out of 1,380 stents placed, 1,090 were DES (79%) and 290 (21%) were BMS. Mortality was higher in the BMS versus DES (8.34% vs. 3.45%, p = .012),ConclusionWe concluded that majority of the population who underwent PCI were older males. DES was used more than BMS. The use of BMS is associated with increased mortality, cardiac complications and Acute Kidney Injury requiring dialysis compared with DES which likely is representative of preferential use of DES in these patient population.
Antithrombotic strategies in patients needing oral anticoagulation undergoing percutaneous coronary intervention: A network meta‐analysis
Authors: Saglietto Andrea , D'Ascenzo Fabrizio , Errigo Daniele , Leonardi Sergio , Dewilde Willem J , Conrotto Federico , Omedè Pierluigi , Montefusco Antonio , Angelini Filippo , De Filippo Ovidio , Bianco Matteo , Gallone Guglielmo , Bruno Francesco , Zaccaro Lorenzo , Giannini Francesco , Latib Azeem , Colombo Antonio , Costa Francesco , De Ferrari Gaetano Maria 
Published: August 2020

AbstractBackgroundThe optimal antithrombotic regimen in patients with a concomitant indication for oral anticoagulation (OAT) presenting with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) remains unclear.ObjectivesTo perform a network meta‐analysis of all randomized controlled trials (RCTs) evaluating different antithrombotic regimens among patients with ACS or undergoing PCI requiring OAT.MethodsNetwork meta‐analysis was performed in a frequentist framework. Antithrombotic regimens were categorized by OAC type (vitamin K antagonist‐based [VKA]; non‐VKA OAT [NOAC]) and antiplatelet agents (P2Y inhibitor only: dual therapy [DAT]; P2Y plus aspirin: triple therapy [TAT]). Safety outcomes were Thrombolysis in Myocardial Infarction (TIMI) major bleeding and intracranial hemorrhage (ICH). Efficacy outcomes were cardiovascular death, myocardial infarction, stroke and stent‐thrombosis (ST).ResultsFive RCTs were included, encompassing 10,797 patients (atrial fibrillation 69–100%, ACS 28–62%, PCI 77–100%). Both VKA and NOAC‐based DAT regimens reduced the occurrence of TIMI major bleeding compared to VKA TAT (VKA DAT: RR 0.62, 95% CI 0.39–0.98; NOAC DAT: RR 0.52, 95% CI 0.39–0.70). Nevertheless, only NOAC DAT significantly reduced the occurrence of ICH compared to VKA TAT (RR 0.33, 95% CI 0.17–0.64). Ischemic outcomes were similar among the four treatment regimens. However, numerical, potentially clinically important, higher ST occurrence was observed for NOAC DAT as compared to both VKA TAT (1.50, 95% confidence interval [CI] 0.96–2.33) and NOAC TAT (1.86, 95% CI 0.93–3.73).ConclusionDAT regimens present the highest safety profile among antithrombotic strategies, with a NOAC‐specific impact on ICH reduction. NOAC DAT might entail clinically important higher ST occurrence, warranting a case‐by‐case comprehensive evaluation that integrates patient‐ and procedure‐related residual ischemic risk with the patient‐specific bleeding risk.
End‐to‐end analysis modeling of vibrational spectroscopy based on deep learning approach
Authors: Wang Xin , Yu Long , Tian Shengwei , Lv Xiaoyi , Meng Xin , Zhang Wendong 
Published: August 2020

AbstractThe characteristics of the spectral data are essential for the qualitative analysis of substances. Traditional classification models often need to preprocess the data. However, misuse of preprocessing may change the characteristic information carried by the original data which result in poor model performance. This paper proposes an end‐to‐end deep learning method that combines residual modules to learn features from raw data to improve model performance, which called ResidualSpectra. ResidualSpectra model is compared with three convolutional neural network (CNN) models on the original data. The 15 preprocessing approaches are used to evaluate the preprocessing impact by testing five open‐access mid‐infrared, near‐infrared, and Raman spectra datasets (fruits, meats, olive_oils, Tablets_Nir, Tablets_Raman). In most cases, the ResidualSpectra model performs better than the other three CNN models on five datasets and obtains better results in original data than in preprocessed data. The model is compared with linear discriminant analysis (LDA), nonlinear artificial neural network (ANN), support vector machines (SVM) for original and preprocessed data. The results show that the ResidualSpectra method provides improved results over traditional classification methods in most scenarios.
Loop‐shaped elements for anchoring carbon reinforcement in concrete
Authors: Speck Kerstin , Rittner Steffen , Bracklow Franz , Ewertowski Mateusz , Curbach Manfred , Cherif Chokri 
Published: August 2020

AbstractCarbon reinforcements enjoy increasing popularity both in building reinforcement and in new construction. The use of yarns with more than 50 000 filaments per roving and finenesses of up to 3300 tex, so‐called heavy tows, enables greater permissible stress and thus increases the performance of the textile reinforced concrete structures. However, high yarn tensile forces with an almost constant roving surface lead to an extension of the required end anchorage and overlap areas. In the project, it was investigated whether a modified loop‐shaped yarn arrangement at the selvages could guarantee force transmission over shorter lengths and thus enables a more economic design of this type of construction. This paper presents the results generated within the investigations, proving the potential of the applied method. Manufacturing possibilities, force transmission mechanisms, material properties, and failure mechanisms were analyzed.
Synergistic Self‐Assembly of Oxoanions and d‐Block Metal Ions with Heteroditopic Receptors into Triple‐Stranded Helicates
Authors: Thevenet Alexiane , Custelcean Radu , Moyer Bruce A. , Jansone‐Popova Santa 
Published: August 2020

AbstractCooperativity effects among the interconnected anion and cation binding sites can profoundly alter the performance of heteroditopic receptors in selective ion pair recognition, processes that are oftentimes pertinent to biological systems and chemical separations. This work reports the effect of the linker that connects both binding sites on self‐assembly of heteroditopic receptors in the presence of divalent first‐row transition metal salts in solution and solid phase. Introduction of backbone flexibility in the receptor results in the formation of triple‐stranded ion‐pair helicates with an extraordinary selectivity towards CuSO4 through an anion‐induced fit.
Dihydroquinazolinones via A3‐Type Reactions of N‐Carbamoyliminium Ions
Authors: Wang Yuanyuan , Oliveira Maria Teresa , Madsen Daniel , Thompson Andrej , Meldal Morten , Diness Frederik 
Published: August 2020

AbstractA variant of the A3 coupling reaction was developed utilizing in situ generated N‐carbamoyliminium ions. The tandem INCIC/A3‐coupling sequence provided a facile one‐pot synthesis of dihydroquinazolinone derivatives. The scope of the reaction was demonstrated in solution as well as on solid support. The reaction was further combined with peptide synthesis, SNAr reactions, CuAAC triazole formation or bromination, providing additional opportunities for further diversification of the dihydroquinazolinone scaffolds.
Mir‐27a‐3p attenuates bronchiolitis obliterans in vivo via the regulation of dendritic cells’ maturation and the suppression of myofibroblasts’ differentiation
Authors: Dong Ming , Wang Xin , Li Tong , Wang Jing , Yang Yunwei , Liu Yi , Jing Yaqing , Zhao Honglin , Chen Jun 
Published: August 2020

AbstractBronchiolitis obliterans (BO), is a chronic rejection phenotype characterized by chronic small airway fibrous obliteration, hinders the patients who suffer from lung transplanting for surviving longer. Cell‐based therapies using dendritic cells (DCs) and T regulatory cells (Tregs) have been developed to regulate allograft rejection, and to induce and maintain immune tolerance. In the present study, the effects of mir‐27a‐3p on regulating DCs as well as resulting effects on BO attenuation have been investigated. According to our reporter assays, the potential targets of mir‐27a‐3p were Smad2, sprouty2, and Smad4, respectively. Furthermore, sprouty2 inhibition by mir‐27‐3p indirectly activated extracellular regulated protein kinases (ERK) and increased IL‐10 production in DCs. This led to a positive feedback loop that maintained the immature state of DCs via IL‐10/JAK/STAT3 pathway, and caused an increase in Foxp3+CD4+ T cells amount as well as TGF‐β level. Furthermore, mir‐27a‐3p regulated TGF‐β function, inhibited TGF‐β/Smad pathway, and suppressed myofibroblast differentiation through influencing the function of Smad2 and Smad4. In short, the study indicated the effect of mir‐27a‐3p on suppressing DC maturation, which implicated the potential clinical application in treating postlung transplant BO.
Pyrotinib combined with CDK4/6 inhibitor in HER2‐positive metastatic gastric cancer: A promising strategy from AVATAR mouse to patients
Authors: Chen Zuhua , Xu Yingying , Gong Jifang , Kou Furong , Zhang Mengqi , Tian Tiantian , Zhang Xiaotian , Zhang Cheng , Li Jian , Li Zhongwu , Lai Yumei , Zou Jianjun , Zhu Xiaoyu , Gao Jing , Shen Lin 
Published: August 2020

AbstractBackgroundPyrotinib was well tolerated but its efficacy was unsatisfactory in patients with HER2‐positive gastric cancer (GC) (NCT02378389). This study was to optimize the efficacy of pyrotinib.MethodsHuman GC cell lines and AVATAR mice were used to explore the refractory mechanisms of pyrotinib. A pyrotinib‐combined strategy was proposed, which was validated in preclinical AVATAR mouse and in clinical patients enrolled in a phase I clinical trial (NCT03480256).ResultsDysregulation of CCND1‐CDK4/6‐Rb axis might be the key to pyrotinib refractory. The strategy of pyrotinib combined with a CDK4/6 inhibitor SHR6390 was proposed and validated in preclinical AVATAR mouse, which was successfully verified in clinical patients. For five patients treated with pyrotinib plus SHR6390 who had available response evaluation, the best response was partial response in three patients, stable disease in one patient, and progressive disease in one patient. The progression‐free survival times were 120, 200, 532, 109, and 57 days, respectively.ConclusionsThis translational study suggests that pyrotinib combined with SHR6390 may serve as a promising strategy for patients with HER2‐positive GC.Trial registrationThe ClinicalTrials.gov identifiers are NCT02378389 (https://clinicaltrials.gov/ct2/show/study/NCT02378389, registered in 11 February 2015) and NCT03480256 (https://clinicaltrials.gov/ct2/show/study/NCT03480256, registered in 8 March 2018).
Interference alignment and scheduling in clustered partially connected small cell networks
Authors: Ghorbani Kosar , Falahati Abolfazl 
Published: August 2020

SummaryInterference alignment (IA) is a beneficial interference management technique in heterogeneous networks (HetNets). Bearing this in mind, we target partially connected networks of small cells that are allocated randomly in a macrocell, whereas IA feasibility conditions may not be satisfied. To address this issue, we propose a new scheme with novel clustering and scheduling algorithms that is accomplished in three stages. The proposed scheme is accomplished by knowing the connection matrix of the established links that is obtained by different threshold values in the first stage. In the second stage, a new clustering algorithm is proposed to separate the cells to groups in which IA is feasible, and the feedback overhead is reduced. In the last stage, cluster scheduling method is proposed to efficiently schedule the clusters. The cluster scheduling allows the selected clusters with trivial intercluster interferences to transmit at the same time slot. The simulation results indicate the improvement of achievable averaged sum rate by the proposed clustering and cluster scheduling.
Prevalence of epilepsy in Bangladesh: Results from a national household survey
Authors: Mohammad Quazi Deen , Saha Narayan Chandra , Alam Md Badrul , Hoque Seikh Azimul , Islam Ariful , Chowdhury Rajib Nayan , Hussain Mohammad Enayet , Chowdhury Yamin Shahriar , Hossain Sakhawat , Chowdhury Mahmood Ahmed , Rahman Matiur , Majumder Bikash Kumar , Salam Abdus , Sarker Amitabh , Uddin Md Kafil , Moniruzzaman Mohammad , Hakim Ferdous , Bhuiyan Rijwan , Anwar Nazneen , Zaman Mohammad Mostafa 
Published: August 2020

AbstractObjectiveTo determine the prevalence and types of epilepsy in Bangladesh.MethodsWe conducted a nationwide population‐based cross‐sectional survey among Bangladeshi population of all ages, except children under one month. We surveyed 9839 participants (urban, 4918; rural, 4920) recruited at their households using multistage cluster sampling. Trained physicians with neurology background confirmed the diagnosis of suspected epilepsy cases identified by interviewer‐administered questionnaires. We reported the overall and sex, residence, and age groups‐specific prevalence of epilepsy per 1000 populations with 95% confidence interval.ResultsThe national prevalence of epilepsy per 1000 was 8.4 (95% CI 5.6‐11.1), urban 8.0 (4.6‐11.4), and rural 8.5 (5.60‐11.5). The prevalence in adult males and females was 9.2 (5.7‐12.6) and 7.7 (3.6‐11.7), respectively. The prevalence in children aged <18 years (8.2, 3.4‐13.0 was similar to adults (8.5 (5.4‐11.4). Among all epilepsy cases, 65.1% had active epilepsy. Their (active epilepsy) prevalence was 5.8 (3.5‐8.1). Of them, 63.4% were not receiving treatment. Moreover, those who received allopathy treatment, 72.5% had low adherence leading to a high treatment gap.SignificanceOur findings out of this first‐ever national survey were similar to other Asian countries. However, the prevalence of active epilepsy and treatment gap were considerably higher. This study serves useful evidence for tailoring interventions aimed to reduce the burden of epilepsy—primarily through targeted community awareness program—and access to antiepileptic treatment in health facilities in Bangladesh.
Internet of underground things‐assisted performance evaluation for underbalanced drilling telemetry systems
Authors: Xie Haiming , Zhou Jing , Zhang Peifen , Kumar Rakesh , Parthasarathy R. 
Published: August 2020

AbstractThis paper presents recent developments with an emphasis on communication technologies, problems with networks, and localization techniques on the Internet of Underground Things (IoUT). Presently, Underground (sensors), communications and network protocols are enabled to allow IoUT validation in an effective way. A new IoUT model is designed to detect and incorporate communications between various industries, such as oil and gas, forestry, earthquake mapping, and the underground boundary protection. Such applications require data collection from the underground resources deployed. While, the challenging underground climate, including sand, rock and water drainages, does not allow a single system of communication. Hence, a new advanced distance‐based approach and Channel Modeling have been developed for performance analysis and the ideal selection of the drilling telemetry system has been potentially analyzed for the development of an extended reservoir region. The predictive value of research is to build a structured and user‐friendly framework for assessing telecommunications efficiency and supporting the decision optimization process. The proposed system has been validated and used for an adequate range of telemetry techniques in under‐balanced drilling operations on a developed reservoir. Expert evaluations show the results and needs of telemetry systems achieve better results.