bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory T Cells Induced by Single-Peptide Liposome Immunotherapy Suppress Islet-Specific T Cell Responses to Multiple Antigens and Protect from Autoimmune Diabetes
Authors: Bergot Anne-Sophie , Buckle Irina , Cikaluru Sumana , Naranjo Jennifer Loaiza , Wright Casey Maree , Zheng Guoliang , Talekar Meghna , Hamilton-Williams Emma E. , Thomas Ranjeny 
Published: February 2020

Abstract
Ag-specific tolerizing immunotherapy is considered the optimal strategy to control type 1 diabetes, a childhood disease involving autoimmunity toward multiple islet antigenic peptides. To understand whether tolerizing immunotherapy with a single peptide could control diabetes driven by multiple Ags, we coencapsulated the high-affinity CD4+ mimotope (BDC2.5mim) of islet autoantigen chromogranin A (ChgA) with or without calcitriol (1α,25-dihydroxyvitamin D3) into liposomes. After liposome administration, we followed the endogenous ChgA-specific immune response with specific tetramers. Liposome administration s.c., but not i.v., induced ChgA-specific Foxp3+ and Foxp3− PD1+ CD73+ ICOS+ IL-10+ peripheral regulatory T cells in prediabetic mice, and liposome administration at the onset of hyperglycemia significantly delayed diabetes progression. After BDC2.5mim/calcitriol liposome administration, adoptive transfer of CD4+ T cells suppressed the development of diabetes in NOD severe combined immunodeficiency mice receiving diabetogenic splenocytes. After BDC2.5mim/calcitriol liposome treatment and expansion of ChgA-specific peripheral regulatory T cells. IFN-γ production and expansion of islet-specific glucose-6-phosphatase catalytic subunit–related protein–specific CD8+ T cells were also suppressed in pancreatic draining lymph node, demonstrating bystander tolerance at the site of Ag presentation. Thus, liposomes encapsulating the single CD4+ peptide, BDC2.5mim, and calcitriol induce ChgA-specific CD4+ T cells that regulate CD4+ and CD8+ self-antigen specificities and autoimmune diabetes in NOD mice.
Inculturation of the Jesus Tradition
Authors: Snyder Graydon F 
Published: February 2020

To understand the cult of the Virgin Mary is to understand the Christian relgion. The Virgin Mary is a ubiquitous but enigmatic presence in Christian history and culture. The tradition about Mary forms a vast and multi-layered aspect of Western history, culture and spirituality. It is not just in the Catholic tradition that Mary has become a particular focus of study and interest. Mary has also become a crucial interest for Christians outside this tradition (Protestant, Anglican) as a path to ecumenical understanding.
This book is intended as a reference book for the student or scholar seeking knowledge of the history and contemporary practice of the cult of the Virgin Mary. It provides new essays which give overviews of particular areas of study - both historical and thematic - together with texts from primary sources and important scholarly articles, some of which appear in English for the first time.
The volume is designed to be suitable for use as a course book at undergraduate and Masters levels. The result is astonishing and will open up whole new avenues for theological and spiritual enquiry. Mary: The Complete Resource will be essential for anyone who has a strong theological or devotional interest in Mary. But it will open the eyes of those who do not.
Research Methods for Early Childhood Education
Authors: Flewitt Rosie , Ang Lynn 
Published: February 2020

Research Methods for Early Childhood Education takes an international perspective on research design, and illustrates how research methods are inextricably linked to cultural and theoretical understandings of early childhood, young children’s competences and the purposes of education.
The book offers a critical and reflective approach to established and innovative research methods in early childhood education, making links between diverse methodologies, methods and theory, with illustrative examples of research in practice. Each chapter addresses a specific methodological approach, linking the methodology to early childhood education with vignettes as examples of research practice in the global north, south, east and west, offering practical examples and critical thinking around new theoretical understandings of early childhood across geographical and cultural contexts.
The book critically examines:
- the role of the researcher
- conceptualisations of how research is undertaken;
- the often sensitive nature of conducting research with young children;
- how early childhood education is understood;
- how young children can be included as active research participants.
Throughout, the book emphasises ethical and methodological issues that arise from undertaking research in mono-cultural and cross-cultural contexts. Annotated further reading lists provide a selection of seminal and recent studies that have adopted each methodological approach
The Literature of Food
Authors: Humble Nicola 
Published: February 2020

Why are so many literary texts preoccupied with food? The Literature of Food explores this question by looking at the continually shifting relationship between two sorts of foods: the real and the imagined. Focusing particularly on Britain and North America from the early 19th century to the present, it covers a wide range of issues including the politics of food, food as performance, and its intersections with gender, class, fear and disgust.
Combining the insights of food studies and literary analysis, Nicola Humble considers the multifarious ways in which food both works and plays within texts, and the variety of functions—ideological, mimetic, symbolic, structural, affective—which it serves.
Carefully designed and structured for use on the growing number of literature of food courses, it examines the food of modernism, post-modernism, the realist novel and children's literature, and asks what happens when we treat cook books as literary texts.
From food memoirs to the changing role of the servant, experimental cook books to the cannibalistic fears in infant picture books, The Literature of Food demonstrates that food is always richer and stranger than we think.
Food Studies
Authors: Zhen Willa 
Published: February 2020

Traditional food studies textbooks tend to emphasize theoretical concepts and text-based approaches. Yet food is sensory, tactile, and experiential. Food Studies: A Hands-on Guide is the first book to provide a practical introduction to food studies. Offering a unique, innovative approach to learning and teaching, Willa Zhen presents creative hands-on activities that can easily be done in a traditional classroom – without the need for a student kitchen. Major theories and key concepts in food studies are covered in an engaging, tangible way, alongside topics such as food production, consumption, technology, identity and culture, and globalization.
A fantastic resource for supporting student engagement and learning, the book features:
practical activities, such as grinding grains to learn about the importance of food technology; working with restaurant menus to understand changes in food trends, tastes, and ingredients; writing food poetry; and many morepedagogical features such as learning objectives, discussion questions, suggested readings, and a glossarya companion website offering lesson plans, worksheets, and links to additional resources.
This is the perfect introduction for students of food studies, anthropology of food, food geography, food hospitality, sociology of food, food history, and gastronomy.
The Image of the Western Neighbor: The History of Poland in Tenth–Seventeenth Centuries in Russian History Textbooks
Authors: Khodnev Aleksandr 
Published: February 2020

Abstract
Marc Ferro stressed that the images from school history might become fixed in memory for the whole life. The history of Poland has a vital place in Russian school textbooks. Russia and Poland have been long-standing neighbors and their relations were not simple in the past. Poland was an important transmission channel of information and experience from Europe to Russia. The Poles played an important role in the construction of Russian identity as one of the key Others. However, the Poles were not considered in Russia as one hundred per cent representatives of the West, but rather as close western neighbors. The history of Poland is regarded as a process associated with the formation of the Russian state. The history of Poland in the sixteenth-seventeenth centuries appears in the textbooks only relating to foreign policy events which involved Russia. Some narratives of the textbooks emphasize that the development of the peoples of Eastern Europe led to a rivalry of Western and Eastern Christianity. The textbooks clearly have a bias towards the history of nations of Western Europe.
What History do Young Ukrainians Need Today? Reinterpretation of the Image of the Polish-Lithuanian Commonwealth in Contemporary Ukrainian Historiography and History Education
Authors: Verbytska Polina 
Published: February 2020

Abstract
The article aims at outlining the problems of reinterpretation of the image of the Polish-Lithuanian Commonwealth in contemporary Ukrainian historiography and history education within the broader context of the discussion on what history the young Ukrainians need today. The study is based on the historiography and contemporary history textbook analyses confronted with the results of the survey held among students and teachers from secondary schools of different regions of Ukraine.
Industry drug development portfolio forecasting: productivity, risk, innovation, sustainability
Authors: Shnaydman Vladimir 
Published: February 2020

Multiple factors may affect industry performance, risk, innovation and sustainability in coming years such as long-term economic trends, patents expiration, demographic shifts, and regulatory issues.

Currently available industry-wide prediction frameworks have limited capabilities. They are based on: (1) analysts’ consensus; (2) extrapolation of current trends; (3) financial performance of big pharma only; (4) empirical formulas, etc. Therefore, the need of robust forecasting methodology based on simulation modeling and covering the entire industry portfolio predictions could not be underestimated.

The simulation model utilizes available data about each drug/indication in the industry R&D pipeline, and transforms it using predictive simulation algorithms into a set of metrics characterizing future industry performance.

Industry-wide portfolio simulation model was developed to address short- and long-term portfolio productivity forecasting challenges. The model is drug–centric, it simulates drug development workflow process. The model also incorporates multiple business rules related to drugs interdependence.

The model predicted 2016 drop in NME approvals based on 2014 data. Other modeling experiments include analysis of industry sustainability and innovation strategy, impact of approval rates and likelihood on the variations of clinical trials cycle time, probabilities of success, and FDA approval cycle time.
Migrations in the Mediterranean Between Protection of Human Rights and Border Control. An Italian Perspective
Authors: Cataldi Giuseppe 
Published: February 2020

Migration through the Mediterranean has to be considered nowadays no more as an emergency. The first urgency is always to save lives at sea, and the Italian Mare Nostrum Operation has been a good example, not followed by EU choices. At the moment border surveillance and the fight against trafficking and smuggling of migrants seem to be the priorities in EU policy and action. The EU Dublin System is now facing a huge crisis and the new models, in particular the Statement agreed with Turkey, do not convince from a legal point of view, mainly because refugees deserve a special attention, based on the non-refoulement principle. The time has come to exit the logic of emergency and formulate a lasting policy to manage migrations, implementing Lisbon Treaty and CFR principles based on solidarity and respect of human rights, as well as on true cooperation among States.
Walter Murch et l’Open Media Framework (OMF) : penser l’interopérabilité pour une ambiguïté fructueuse
Authors: Gervais Simon 
Published: February 2020

Walter Murch est l’un des rares monteurs de cinéma américain qui pratique le montage image et le montage sonore. Parce que sa pensée du montage fait chevaucher les continuums visuel et sonore, le rapport de Walter Murch au montage s’apparente à l’interopérabilité. Cet article explore d’abord la notion d’interopérabilité dans le contexte du cinéma en observant le format de fichier Open Media Framework Interchange (OMF). Conçue dans les années 1990, cette innovation est un protocole technique qui ouvre des canaux de communication entre les logiciels de montage image et sonore. Cet article soulève ensuite les conséquences des conceptions pratiques et philosophiques de l’OMF sur les pratiques, au quotidien, du montage image et sonore, pour les faire résonner avec la « pensée-montage » de Murch. Plus que tout, il cherche à décrire les réels enjeux d’une pratique interopérable du montage.
Un essai d’éthique et de pratique politique : San Michele aveva un gallo de Paolo et Vittorio Taviani
Authors: Marini Alessandro 
Published: February 2020

Cet article s’intéresse au film San Michele aveva un gallo de Paolo et Vittorio Taviani (1972), une adaptation du récit Le divin et l’humain de Tolstoï (1906). On retrouve au centre de la réflexion des deux oeuvres un discours sur la transformation possible de la société dans laquelle elles se situent. Dans le film, l’histoire de Giulio Manieri, un anarchiste internationaliste du xixe siècle, fait allusion de façon allégorique au climat contemporain – les luttes populaires de la fin des années 1960 – et exprime le processus de marginalisation des instances révolutionnaires qui le caractérisèrent. Le parcours tragique de Giulio – révolution, emprisonnement et suicide – représente ainsi une sorte d’épitaphe sur la fin des espoirs de transformation de la société italienne suscités par la Résistance et désormais définitivement perdus. Cet article a pour but de mettre en évidence la façon dont le scénario, la construction de l’espace scénique et les références extratextuelles contribuent à donner forme à un apologue sociopolitique dépourvu d’illusions.
Neck Circumference as a Screening Tool for Overweight and Obesity in Children
Authors: Nimawat Amit Kumar , Gupta Virendra Kumar , Natani Bhagwan Sahai , Verma Chaman Ram 
Published: February 2020

Introduction: Obesity is an emerging epidemic worldwide causing serious public health concern. The upper part of the body as Neck circumference (NC) can be used as a simple and time saving screening tool to evaluate it.
Materials and Methods: From January 2018 to June 2019, this school-based prospective observational study was conducted in schools of rural and urban areas near Jaipur taking 1000 children between age group of 6 to14 years. Children with conditions likely to interfere with neck circumference measurement were excluded. All anthropometric measurements were taken with standard techniques, and children were divided as normal, overweight or obese.
Results: Out of 1000 subjects, 364 males and 428 females were normal weight, 44 males and 68 females were overweight and 41 males and 19 females were found obese.
Intra group comparison of neck circumference in male & females showed significant correlation between normal, overweight & obese children. There was a good positive correlation between BMI and NC for all children.
Conclusion: Neck circumference can be used with great reliability to screen overweight and obesity in children.
Tūhono Māori: Promoting Secure Attachments for Indigenous Māori Children. A Conceptual Paper
Authors: Mikahere-Hall Alayne 
Published: February 2020

Tūhono Māori is a Kaupapa Māori research project that seeks to contribute to the healing and success of vulnerable Māori children and their families. This paper is the first of two papers presented in this issue related to the Tūhono Māori research project. The Tūhono Māori study investigates traditional and contemporary notions of secure whānau attachment that promote tamariki security and wellbeing. Tūhono Māori has a broad aim to enable improved child welfare, practitioner, agency, and whānau (family), hapū (extended family), and iwi (collective kin group) responses to the needs of indigenous Māori children and their whānau. This paper presents an overview of the prevailing context, intersecting spaces and conceptual ideas inherent within systems in New Zealand, and the impact these have had on Māori security. The paper argues for alternative systems within the New Zealandcontext to enable conditions which facilitate emotional security for Māori children andtheir whanau.
High‐Performance, Long‐Life, Rechargeable Li–CO2 Batteries based on a 3D Holey Graphene Cathode Implanted with Single Iron Atoms
Authors: Hu Chuangang , Gong Lele , Xiao Ying , Yuan Yifei , Bedford Nicholas M. , Xia Zhenhai , Ma Lu , Wu Tianpin , Lin Yi , Connell John W. , Shahbazian‐Yassar Reza , Lu Jun , Amine Khalil , Dai Liming 
Published: February 2020

AbstractA highly efficient cathode catalyst for rechargeable Li–CO2 batteries is successfully synthesized by implanting single iron atoms into 3D porous carbon architectures, consisting of interconnected N,S‐codoped holey graphene (HG) sheets. The unique porous 3D hierarchical architecture of the catalyst with a large surface area and sufficient space within the interconnected HG framework can not only facilitate electron transport and CO2/Li+ diffusion, but also allow for a high uptake of Li2CO3 to ensure a high capacity. Consequently, the resultant rechargeable Li–CO2 batteries exhibit a low potential gap of ≈1.17 V at 100 mA g−1 and can be repeatedly charged and discharged for over 200 cycles with a cut‐off capacity of 1000 mAh g−1 at a high current density of 1 A g−1. Density functional theory calculations are performed and the observed appealing catalytic performance is correlated with the hierarchical structure of the carbon catalyst. This work provides an effective approach to the development of highly efficient cathode catalysts for metal–CO2 batteries and beyond.
Supramolecular Organic Frameworks with Controllable Shape and Aggregation‐Induced Emission for Tunable Luminescent Materials through Aqueous Host–Guest Complexation
Authors: Li Yawen , Qin Chunyan , Li Qingfang , Wang Pinpin , Miao Xiaran , Jin Huilin , Ao Wantong , Cao Liping 
Published: February 2020

AbstractHere, a series of shape‐controllable and fluorescent supramolecular organic frameworks (SOFs) exhibiting aggregation‐induced emission (AIE) are reported as a new kind of tunable luminescent material, constructed hierarchically from fluorescent guests (1–5) and cucurbit[8]uril (CB[8]) through homo/hetero host–guest complexation in water. These SOFs can further form regular supramolecular cuboids via a hierarchical assembly process in the solid state. Interestingly, the emission of hetero‐SOFs systems exhibiting AIE, which are a combination of two or three SOFs with two complementary colors (i.e., yellow and blue) or three primary RGB colors (red, green, and blue) through the hetero host–guest complexation between CB[8] and two pyridinium rings of different guests, can be easily tuned by adjusting the excitation wavelength and guests ratios, thereby achieving a wide‐color tunability (≈64% sRGB area) and white‐light emission (0.31, 0.34) in the solution state. This study therefore provides insight into the fabrication of tunable luminescent materials based on SOFs with controllable shapes and AIE properties as fluorescent platforms, and may facilitate the further design and synthesis of tunable luminescent materials and other fluorescent supramolecular systems based on host–guest complexation both in the solution and solid states.
Morphological (and not anatomical or reproductive) features define early vascular plant phylogenetic relationships
Authors: Niklas Karl J. , Crepet William L. 
Published: February 2020

PremisePerhaps the most rapid period of vascular plant evolution occurred during the Silurian–Devonian time interval. Yet, few quantitative analyses have established the extent to which anatomical, morphological, or reproductive features contributed to this episode of tracheophyte diversification.MethodsPhylogenetic analyses were performed using a newly revised matrix of 54 characters (with 158 character states) of 37 of the best‐preserved Paleozoic (predominantly Devonian) plants. Equisetum was included to determine whether it aligns with fossil sphenopsids or taxa collectively considered “ferns”. The topology of the 54‐character consensus tree was then compared to the topologies generated using only reproductive features (18 characters; 47 character states), only anatomical features (14 characters; 54 character states), only morphological features (22 characters; 57 character states), and the three pairwise combinations (e.g., anatomical and morphological characters).ResultsThe new 54‐character tree topology continued to identify a trimerophyte‐euphyllophyte clade and a zosterophyllophyte‐lycophyte clade emerging from a Cooksonia‐rhyniophyte plexus. Equisetum aligned with fossil sphenopsids rather than fern‐like fossil taxa. Reproductive characters or anatomical characters analyzed in isolation resulted in nearly complete polytomy. Among the various permutations of the three categories, anatomical and morphological characters when combined provided the best restoration of the 54‐character tree topology.ConclusionsThe phylogenetic relationships among the canonical fossil taxa used in this analysis predominantly reflect morphological trends. Reproductive and anatomical features taken in isolation appear to be evolutionarily conservative characters, i.e., natural selection “sees” the external phenotype.
Northern pigtailed macaques rely on old growth plantations to offset low fruit availability in a degraded forest fragment
Authors: Gazagne Eva , José‐Domínguez Juan Manuel , Huynen Marie‐Claude , Hambuckers Alain , Poncin Pascal , Savini Tommaso , Brotcorne Fany 
Published: February 2020

AbstractSpace‐use and foraging strategies are important facets to consider in regard to the ecology and conservation of primates. For this study, we documented movement, ranging, and foraging patterns of northern pigtailed macaques (Macaca leonina) for 14 months in a degraded habitat with old growth Acacia and Eucalyptus plantations at the Sakaerat Biosphere Reserve in northeastern Thailand. We used hidden Markov models and characteristic hull polygons to analyze these patterns in regard to fruit availability. Macaques' home range (HR) was 599 ha and spanned through a natural dry‐evergreen forest (DEF), and plantation forest. Our results showed that active foraging increased with higher fruit availability in DEF. Macaques changed to a less continuous behavioral state during periods of lower fruit availability in DEF, repeatedly moving from foraging to transiting behavior, while extending their HR further into plantation forest and surrounding edge areas. Concomitantly, macaques shifted their diet from fleshy to dry fruit such as the introduced Acacia species. Our results showed that the diet and movement ecology adaptations of northern pigtailed macaques were largely dependent on availability of native fruits, and reflected a “high‐cost, high‐yield” foraging strategy when fresh food was scarce and dry fruit was available in plantation forest. Conversely, wild‐feeding northern pigtailed macaque populations inhabiting pristine habitat approached a “low‐cost, low‐yield” foraging strategy. Our results outline the effects of habitat degradation on foraging strategies and show how a flexible species can cope with its nutritional requirements.