bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive factors for the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma
Authors: Lee Ryang-Hun , Kim Jae Min , Cheong Jin Hwan , Ryu Je Il , Kim Young Soo , Han Myung-Hoon 
Published: November 2019

AbstractBackground and purposeDisruption of the tumor-brain barrier in meningioma plays a critical role in the development of peritumoral brain edema (PTBE). We hypothesized that osteoporotic conditions may be associated with PTBE occurrence after radiation in patients with intracranial meningioma.MethodsWe measured Hounsfield units (HU) of the frontal skull on simulation brain CT in patients who underwent linear accelerator (LINAC)-based radiation treatment for intracranial meningioma. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for several predictive factors. The cumulative hazard for PTBE was estimated and classified according to these factors. Hazard ratios were then estimated to identify independent predictive factors associated with the development of PTBE after radiation in intracranial meningioma patients.ResultsA total of 83 intracranial meningiomas in 76 patients who received LINAC-based radiation treatment in our hospital over an approximate 5-year period were included for the study. We found mean frontal skull HU ≤630.625 and gross tumor volume >7.194 cc to be independent predictors of PTBE after radiation treatment in patients with meningioma (hazard ratio, 8.38; P=0.021; hazard ratio, 5.78; P=0.034, respectively). In addition, patients who were ≥65 years showed a marginally significant association with PTBE.ConclusionsOur study suggests that possible osteoporotic conditions, large tumor volume, and older age may be associated with PTBE occurrence after LINAC-based radiation treatment for intracranial meningioma. In the future we anticipate that these findings may enhance the understanding of the underlying mechanisms of PTBE after radiation in meningioma patients.
An accurate molecular method to sex savannah elephants using PCR amplification of Amelogenin gene
Authors: Lohay George G 
Published: November 2019

AbstractThe use of molecular methods to identify the sex of elephants from non-invasive samples is essential for studies of population dynamics and population genetics. We designed a new technique for sex identification in savannah elephants using Amelogenin (AMEL) genes. The X-Y homologs of AMEL genes is known to be suitable for sex determination in pigs and some bovids. In this study on savannah elephants, the use of AMEL genes was more successful than previous methods that relied on genes found exclusively on Y-chromosomes, such as SRY, to distinguish males from females. We designed a common forward primer and two reverse primers for X- and Y-specific AMEL genes to obtain 262 bp and 196 bp PCR amplicons from X and Y genes, respectively. We tested the primers for the identification of the sex of 132 savannah elephants from fecal samples. The sex of 126 individuals (95.45%) matched observational data, while 6 (4.54%) did not match. This discrepancy observed was likely due to observational errors in the field, where high grass reduces the ability to accurately sex young individuals. Through our stool sample results, we have shown that the use of only three primers for AMELX/Y provides a highly accurate PCR-based method for sex identification in savannah elephants. The method is fast and shows more success than the SRY system by avoiding the inherent ambiguities of the previous PCR-based methods that made it difficult to distinguish between female samples and failed amplification reactions. Our sex identification method is non-invasive and can potentially be applied in population genetic studies and forensics tests on both savannah as well as forest elephants.
Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
Authors: Bogdanow Boris , Schmidt Max , Weisbach Henry , Gruska Iris , Vetter Barbara , Imami Koshi , Ostermann Eleonore , Brune Wolfram , Selbach Matthias , Hagemeier Christian , Wiebusch Lüder 
Published: November 2019

SUMMARYHerpesviruses encode conserved protein kinases to stimulate phosphorylation-sensitive processes during infection. How these kinases bind to cellular factors and how this impacts their regulatory functions is poorly understood. Here, we use quantitative proteomics to determine cellular interaction partners of human herpesvirus (HHV) kinases. We find that these kinases can target key regulators of transcription and replication. The interaction with Cyclin A and associated factors is identified as a specific signature of β-herpesvirus kinases. Cyclin A is recruited via RXL-motifs that overlap with nuclear localization signals (NLS) and locate in the non-catalytic N-terminal regions. This architecture is conserved for viral kinases of HHV6, HHV7 and rodent CMVs. Docking to Cyclin A competes with NLS function, enabling dynamic changes in kinase localization and substrate phosphorylation. The viral kinase redirects Cyclin A to the cytosol, which is essential for the inhibition of cellular DNA replication during infection. Our data highlight a fine-tuned and physiologically important interplay between a cellular cyclin and viral kinases.
Temporal Dynamics of the Neural Representation of Social Relationships
Authors: Dziura Sarah L. , Thompson James C. 
Published: November 2019

AbstractHumans can rapidly encode information from faces to support social judgments and facilitate interactions with others. We can also recall complex knowledge about those individuals, such as their social relationships with others, but the timecourse of this process has not been examined in detail. This study addressed the temporal dynamics of emerging visual and social relationship information using electroencephalography (EEG) and representational similarity analysis (RSA). Participants became familiar with a 10-person social network, and were then shown faces of that network’s members while EEG was recorded. To examine the temporal dynamics of the cognitive processes related to face perception, we compared the similarity structure of neural pattern responses to models of visual processing, face shape similarity, person identity, and social connectedness. We found that all types of information are associated with neural patterns after a face is seen. Visual and identity models became significant early after image onset, but only the identity model stayed associated with neural patterns until 400 ms. Models representing social connections were also present beginning around 200 ms, even in the absence of an explicit task to think about the friendships among the network members. A partial correlation showed that visual and social information contribute uniquely to person perception, although differences were found between models of social connection. This study highlights the speed and salience of social information relating to group dynamics that are present in the brain during person perception.Significance StatementWe live our lives in social groups where complex relationships form among and around us. It is likely that some of the information about social relationships that we observe is integral during person perception, to better help us interact in differing situations with a variety of people. However, when exactly this information becomes relevant has been unclear. In this study, we present evidence that information reflecting observed relationships among a social network is spontaneously represented in whole-brain patterns shortly following visual perception, and is uniquely present around 400 ms. These results are consistent with neuroimaging studies showing spontaneous spatial representation of social network characteristics, and contribute novel insights into the timing of these neural processes.
Kinetochore phosphatases suppress autonomous kinase activity to control the spindle assembly checkpoint
Authors: Cordeiro Marilia H , Smith Richard J , Saurin Adrian T 
Published: November 2019

AbstractLocal phosphatase regulation is critical for determining when phosphorylation signals are activated or deactivated. A typical example is the spindle assembly checkpoint (SAC) during mitosis, which regulates kinetochore PP1 and PP2A-B56 activities to switch-off signalling events at the correct time. In this case, kinetochore phosphatase activation dephosphorylates MELT motifs on KNL1 to remove SAC proteins, including the BUB complex. We show here that, surprisingly, neither PP1 or PP2A are required to dephosphorylate the MELT motifs. Instead, they remove polo-like kinase 1 (PLK1) from the BUB complex, which can otherwise maintain MELT phosphorylation in an autocatalytic manner. This is their principle role in the SAC, because both phosphatases become redundant if PLK1 is inhibited or BUB-PLK1 interaction is prevented. Therefore, phosphatase regulation is critical for the SAC, but primarily to restrain and extinguish autonomous kinase activity. We propose that these circuits have evolved to generate a semi-autonomous SAC signal that can be synchronously silenced following kinetochore-microtubule tension.
Preferences for vegetables among university foodservice users
Authors: Holligan Simone , Yi Sunghwan , Kanetkar Vinay , Haines Jess , Dergham Jana , Royall Dawna , Brauer Paula 
Published: November 2019

PurposeThe purpose of this paper is to assess the meal selection and potential vegetable substitution preferences in a sample of university students, to inform design of planned nudge interventions for increasing vegetable intake in on-campus cafeterias. The setting was a public university in southern Ontario, Canada.Design/methodology/approachAn online survey was disseminated via multiple channels, and 686 undergraduate students responded. The frequency of purchasing specific meals on campus was queried first to set context, and then preferences for meal types (wraps, pasta, etc.), followed by preferences for vegetables to be added within meal types.FindingsFor portable meal options such as sandwiches, pitas and wraps, preferred vegetables for modification were cucumbers, spinach, tomatoes and bell peppers, and having vegetable toppings and raw cauliflower or broccoli as sides with pizza. For burgers or hotdogs, preferred sides were garden salad, cucumber slices and carrot sticks. Broccoli was the most preferred vegetable addition and substitution for sit-down meals, such as meals of chicken, beef, pork or fish with a side of potatoes or rice.Practical implicationsThe findings can be used to design nudge interventions in university cafeterias by incorporating preferred vegetables into composite meals frequently purchased by students.Originality/valueFew nudge studies to date have incorporated more vegetables into existing composite meals and offering them as the new default. Stated preferences are a reasonable starting point for the design of such interventions.
On the potential of integrating building information modelling (BIM) for the additive manufacturing (AM) of concrete structures
Authors: Gradeci Klodian , Labonnote Nathalie 
Published: November 2019

Purpose
Additive manufacturing (AM) and building information modelling (BIM) are emerging trends for which it has been claimed that both increase both efficiency and productivity in the construction industry. This study aims to synthesise and aggregate the literature addressing BIM integration in the AM of concrete structures and to exploit the joint value creation potential.

Design/methodology/approach
This study firstly applies a mixed-review method to achieve mutual corroboration and interdependency between quantitative and qualitative research approaches. Bibliometric mapping is applied to identify, map and synthesise the relevant literature. Scoping review is used to examine the extent, gap, range and nature of the research activity. Afterward, a cross-situational analysis, the threats, opportunities, weaknesses and strengths2 matrix, is proposed and applied to exploit the joint value creation potential of different aspects of AM and BIM.

Findings
The study reveals a substantial interest in this field. However, progress in terms of integration is slow compared to the rapid development in interest in the two trends individually. The literature discusses or conceptualises such integration at building-scale, while prototyping or proof-of-concept processes are only rarely used. The study identified 12 joint value creation potentials through the integration of BIM in AM for concrete structures, which can create value by enabling more optimised designs, automated construction processes and data analytics that can apply throughout the building life-cycle process.

Originality/value
The advancements of BIM integration in the AM of concrete structures are analysed and joint value creation potentials are proposed. The study proposes a cross-situation analysis that can be applied to structure joint value creation potentials from the multi-dimensional integration of different factors and topics, especially for emerging technologies.
Opening spaces of restoration for youth through community-engaged critical literacy practices
Authors: Hadley Heidi Lyn , Burke Kevin J. , Wright William Terrell 
Published: November 2019

PurposeThe purpose of this paper is to explore how critical literacy practices within a community youth program opened spaces for restoration for youth. In turn, youth created civic conversations about race, juvenile justice and school discipline inequities to enact change within their community.Design/methodology/approachThis qualitative study used ethnographic methods such as interviews and observation to collect data from youth, community members and adults who run the youth center. Data were analyzed using constant comparative analysis.FindingsYouth created spaces of restoration by reclaiming historicized narratives about themselves, their families and their community. Youth engaged critical literacy practices to explore their own identity, critique inequality in their community and work as community organizers to lead adults in conversations for change.Originality/valueThis paper explores how critical literacy practices have restorative value when youth use them in authentic ways to research community problems and work for change.
Returns management employee development: antecedents and outcomes
Authors: Chen Haozhe , Genchev Stefan E. , Willis Geoff , Griffis Benjamin 
Published: November 2019

PurposeThe purpose of this paper is to empirically investigate the antecedents and impacts of a largely overlooked concept, employee development, within the challenging area of returns management.Design/methodology/approachThe proposed relationships are validated through structural equation modeling analysis with survey data collected in India.FindingsCombining the ability–motivation–opportunity model in human resource management and the theoretical tenets associated with dynamic capabilities, the authors confirmed that supply chain learning, returns management orientation and information support are important antecedents of returns management employee development. In turn, the findings suggest that, as a dynamic capability, returns management employee development positively impacts a firm’s returns management and market performance.Practical implicationsTo successfully tackle the challenges related to handling returns, companies must focus their resources not only on new technologies and related processes, but also on employee training and development as well.Originality/valueAlthough recruiting and retaining talent in supply chain management has long been recognized as a serious global challenge, no previous research has empirically studied employee development practices in the returns management context.
Team learning capability – an instrument for innovation ambidexterity?
Authors: Batt-Rawden Victoria Helen , Lien Gudbrand , Slåtten Terje 
Published: November 2019

PurposeThe aim of this paper is to develop the concept of team learning capability in professional service firms. Thereafter, to examine the effect of team learning capability on innovation ambidexterity. The aspects of exploitive and explorative knowledge creation in teams and its impact on incremental and radical service innovation are in focus.Design/methodology/approachStructural equation modelling was applied to establish reliability and validity and measure the size of relationships. Evidence is drawn upon an empirical sample of 210 consultants in the professional service industry.FindingsThe findings support the concept of team learning capability and reveal that team learning capability consists of relationship learning in teams, trusting team climate and employee commitment. The results indicate a strong positive relationship between team learning capability and innovation ambidexterity in professional service firms.Originality/valueThis study is the first to offer an empirical-based and contextualized framework for team learning capabilities and a valid measure.
Executive marketing background, corporate trademark and brand management
Authors: Chen Chao , Luo Rongxi 
Published: November 2019

PurposeWith many years’ economic transformation from “Made in China” to “Created in China,” the State Council has set May 10th as annual “China’s Brand Day” from 2017. This action indicates the implementation of brand strategy and the new national policy of promoting China’s brands. The purpose of this paper is to examine the influence of marketing background of top management team (TMT) on trademark and brand output.Design/methodology/approachUsing the trademark application data of Chinese-listed companies, this paper constructs a multiple linear regression model and uses the OLS method. This research also uses two-stage regression to examine the effect of endogeneity on the results.FindingsOur results show that the higher the proportion of executives with marketing background in TMT, the more the number of trademark applications. Furthermore, we document that the positive impact of TMT marketing background on the number of trademark applications is more pronounced in non-state-owned enterprises, companies with more patent output and companies whose CEO has marketing background, indicating that when TMT can play a bigger role, companies have better innovation ability and team collaboration is more efficient, the promoting role of TMT marketing background on the number of corporate trademark applications will be stronger.Originality/valueThis research focuses on the world’s largest emerging economy – China, which is different from the existing literature that is mainly based on western developed countries. With China’s economy stepping into a new normal and consumption upgrading, it is important and worthy of a deep discussion about which factors affect the company’s trademark and brand management.
Payment instruments choice of Russian consumers: reasons and pain points
Authors: Semerikova Ekaterina 
Published: November 2019

Purpose
The paper aims to explore reasons for choosing different payment instruments and pain points from using them in a Russian context. It proposes that given the expansion of the range of personal payment instruments, the choice for payment is now influenced by many factors, including the type of financial provider and potential benefits for consumers.

Design/methodology/approach
This paper is an exploratory study that uses data from the qualitative research conducted in three Russian cities (Moscow, Yekaterinburg and Saratov) based on 50 online payment diaries and 12 group discussions. It was complemented by the analysis of consumers’ posts on six relevant media platforms.

Findings
The results show that a bank card is a new must and people choose it for convenience, safety and access to online purchases inside and outside Russia. Cash is used out of habit or wherever cashless payments are either not free or unavailable. Reasons for smartphone pass-through wallet usage include speed, attribute of style and higher cashbacks.

Research limitations/implications
The limitations of the study are similar to any qualitative research and include, in particular, lack of generalization. Proposed hypotheses might be further tested quantitatively on a representative sample.

Practical implications
The results might help providers of financial services in creating better quality products that address consumer pain points and in developing strategies that allow for the changing preferences of consumers.

Originality/value
To the authors’ knowledge, this is the first such study to consider reasons for choosing and pain points from using certain payment instruments in the emerging markets, in particular, Russia.
Judgments of acquisition value and transaction value
Authors: Soni Nitin , Dawra Jagrook 
Published: November 2019

Purpose
An open question of behavioral pricing literature is: What are the factors which influence consumers’ judgments of acquisition value and transaction value? An important framework to explain consumers’ shopping and purchase decisions is their decision-making styles. This paper aims to examine the influence of consumers’ decision-making styles, that is, perfectionistic high-quality conscious, brand conscious-price equals quality, novelty-fashion conscious, recreational-hedonistic, price conscious-value for money, impulsive-careless, habitual-brand loyal and confused by overchoice on their judgments of acquisition value and transaction value.

Design/methodology/approach
From the literature, a conceptual framework was formulated. Data was collected from a survey of 304 respondents. The measurement model was tested using exploratory factor analysis and confirmatory factor analysis. The structural model was tested using structural equation modeling.

Findings
The consumers’ judgments of acquisition value and transaction value vary with their decision-making styles. The measurement and structural models exhibited good fit, and 12 of the 16 proposed hypotheses were found to be significant.

Research limitations/implications
The respondents for this research study were urban and postgraduate students.

Practical implications
The results of this study can help managers personalize their promotional offers and market offerings targeted at consumers with different decision-making styles.

Originality/value
Behavioral pricing literature has not convincingly shown that consumers make the judgments of the two values, acquisition value and transaction value, in a purchase scenario. There is limited literature on the impact of decision-making styles on the marketing variables. The results of this study contribute to the literature by showing that consumers make the judgments of these two values, and these judgments vary with their decision-making styles. Also, this is one of only a few studies to examine the two components of the purchase value in an Indian context.