bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring of Genetically Modified Rice among Some Imported Rice Samples in Iran
Authors: Hosseini M.S. , Fallahzadeh H. , Hosseini S.S. 
Published: December 2020

Background: Genetically Modified (GM) foods are produced using genetic engineering. This survey attempted to identify the presence of GM rice varieties among some imported rice samples in Iran.
Methods: From May to July 2016, a total of 50 samples of the imported rice to Iran were obtained, including 20 bulk rice samples from Bandar Abbas custom, Southern Iran and 30 retail rice samples from some commercial brands sold in the local markets of Yazd, Iran. Polymerase Chain Reaction was used to assess the GM varieties.
Results: None of the studied rice samples had the target genes related to GM products.
Conclusion: This study indicated no evidence for presence of GM rice among some bulk and retail imported rice samples in Iran. Since marketing of GM rice is not legally permitted in Iran, more comprehensive studies must be designed with higher sample size in various provinces of country to achieve more detailed data about situation of GM rice in the Iranian markets.
“Der Emes”: newspaper, printing house, publishing house
Authors: Khazdan Sofia E. 
Published: December 2020

Many Russian, Soviet and foreign Russian-­language publications since 1882 were called “Pravda”. Some of them (the newspaper, the printing house and the publishing house) had a similar name in Yiddish containing Hebraism – “Der Emes”. The main problem of the research is to identify interaction points of these organizations. The purpose of this study isto find out how these print media relate to each other. The author considers their history on the basis of archival documents and memoirs of employees of these institutions. The analysis of publishing production was carried out on materials of the bulletin of the Russian Book Chamber and collections of Jewish publications found in two main libraries of Russia. The author has identified several printing houses with the same name of different subordination, working with printed products in Yiddish and Russian. The author came to the conclusion that the newspaper editorial board, the Printing house and the Publishing house “Der Emes” were in close cooperation.
Speciality 05.25.03 “Library science, bibliography and book science”. What are the prospects?
Authors: Brezhneva Valentina V. , Dvorkina Margarita Ya. , Kalegina Olga A. , Lopatina Natalya V. , Stolyarov Yuri N. 
Published: December 2020

The material presents the views of the chairs and members of the dissertation councils at the KazGIK, MGIK, SPGIK and RSL on the specialty 05.25.03 indicated in the title on four issues: 1. Are you confident in the future of your dissertation council? What is your confidence or anxiety related to? 2. What do you think are the problems of modern library science, bibliography and book studies? 3. There are only 4 dissertation councils on the specialty – 03.25.03 – in Russia: in Kazan, Moscow, St. Petersburg, Khimki. Do you think this is sufficient for the development of our industry? 4. What question (s) on the dissertation council would you like to be asked?The answers showed concern for the future of not only of dissertation counsils as such, but confirmed serious concerns about the future of the specialty 05.25.03.
Surgical Treatment of Distal Radial Fractures with External Fixation Versus Volar Locking Plate
Authors: Ludvigsen Trine , Matre Kjell , Gudmundsdottir Rakel Sif , Krukhaug Yngvar , Dybvik Eva Hansen , Fevang Jonas Meling 
Published: December 2020

Background:
The use of volar locking plate fixation (VLP) for unstable extra-articular distal radial fractures has increased in the last decades. External fixation (EF) is less frequently used. This change of surgical approach has only to some extent been evidence-based.

Methods:
In this multicenter, randomized controlled trial, we compared VLP and EF in patients between 18 and 70 years of age who had a displaced extra-articular distal radial fracture (OTA/AO type A3). The patients were examined at 6 weeks, 3 months, and 1 year postoperatively. The primary outcome measure was the Patient-Rated Wrist/Hand Evaluation score (PRWHE). Secondary outcomes were the shortened version of the Disabilities of the Arm, Shoulder and Hand (QuickDASH), pain score on a visual analog scale (VAS), and radiographic measurements. Range of motion, grip strength, finger stiffness, complications, and reoperations were also recorded.

Results:
One hundred and fifty-six patients were included. One hundred and forty-two (91%)—127 women (89%) and 15 men (11%)—completed 1 year of follow-up. Sixty-nine patients were treated with VLP and 73, with EF. The mean age was 56 years. At 6 weeks, the median PRWHE score was significantly higher in the EF group (44) compared with the VLP group (27) (p < 0.001). At 3 months and 1 year, the difference between groups was not significant. The median QuickDASH score was 27 in the VLP group and 43 in the EF group at 6 weeks (p < 0.001), and a significant difference persisted at 3 months (p = 0.023). The VLP group had superior results in terms pain during activity, wrist extension, and ulnar and radial deviation at 1 year, whereas the number of major complications was similar in the 2 groups.

Conclusions:
Patients treated with VLP had earlier recovery of function compared with patients treated with EF. One year postoperatively, we found no significant functional difference.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Clinical and Health-Care Cost Analysis of Negative Pressure Dressing in Primary and Revision Total Knee Arthroplasty
Authors: Yaghmour Khaled M. , Hossain Fahad Siddique , Konan Sujith 
Published: December 2020

Background:
Negative pressure wound therapy (NPWT) has been used because of its perceived advantages in reducing surgical site infections, wound complications, and the need for further surgery. The purpose of this study was to assess the infection rates, wound complications, length of stay, and financial burden associated with NPWT use in primary and revision total knee arthroplasty (TKA).

Methods:
We performed a PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) systematic review of the existing literature on using NPWT in primary and revision TKA. PubMed, Embase, Science Direct, and the Cochrane Library were utilized. The risk of bias was evaluated using the ROBINS-I (Risk Of Bias In Non-randomised Studies - of Interventions) tool, and the quality of evidence was evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) criteria.

Results:
Twelve articles that evaluated 1,403 primary TKAs and 279 revision TKAs were reviewed. NPWT significantly reduced complication rates in revision TKA. However, there was no significant difference in infection rates between NPWT and regular dressings in primary or revision TKA. NPWT use in primary TKA significantly increased the risk of blistering, although no increase in reoperations was noted. The analysis showed a possible reduction in length of stay associated with NPWT use for both primary and revision TKA, with overall health-care cost savings.

Conclusions:
Based on a meta-analysis of the existing literature, we do not recommend the routine use of NPWT. However, in high-risk revision TKA and selected primary TKA cases, NPWT reduced wound complications and may have health-care cost savings.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Occurrence of L4 Lumbar Artery Pseudoaneurysm After Posterior Reduction and L4-L5 Fusion for Grade I Anterolisthesis
Authors: Ruffilli Alberto , Barile Francesca , Fiore Michele , Pasini Stefano , Facchini Giancarlo , Faldini Cesare 
Published: December 2020

Case:
We describe the case of a 53-year-old man who developed acute groin pain 20 days after a posterior L4-L5 interbody fusion. Despite positioning of pedicle screws within the safe zone, an L4 right lumbar artery pseudoaneurysm was found on computer tomography angiogram. Coil embolization was successfully performed.

Conclusion:
Iatrogenic lumbar artery pseudoaneurysms are a rare complication of spinal surgery. Our case is, to the best of our knowledge, the only reported case where this lesion occurred despite good positioning of the screws: It is therefore important to always suspect and exclude this complication in case of suggestive symptoms.
Resect or Retain Bone Fragments in Children and Teenagers with Severe Open Fractures?
Authors: Rölfing Jan Duedal , Bue Mats , Kiil Birgitte , Petruskevicius Juozas 
Published: December 2020

Case:
A 14-year-old pedestrian was hit by a car and encountered similar bilateral Gustilo IIIB open tibial fractures. The right tibial fracture involved a large borderline vital butterfly fragment without periosteal contact, which was retained and proceeded to sufficient healing within 12 weeks. The left tibial fracture was treated according to the principles for the treatment of severe open fractures in adults, involving resection of devitalized fragments and bone transport, and healed within 15 months.

Conclusions:
Teenagers do possess larger bone healing potential than adults. Therefore, a rapid bone union can be achieved even with apparently devitalized bone fragments if sufficient soft-tissue closure and stable fracture fixation is established early in the treatment of open limb fractures.
Surgical Technique for Anterior Approach for Total Hip Arthroplasty After Bilateral Below-Knee Amputation
Authors: Mahmood Mustafa , Samuel Linsen T. , Kamath Atul F. 
Published: December 2020

Case:
We report a case of a 77-year-old man, with bilateral below-knee amputee, in whom the anterior approach (AA) for a left total hip arthroplasty was used successfully, with 3-year follow-up. This report also summarizes the key studies in the literature on this subject.

Conclusions:
The utility of AA surgery performed in the setting of bilateral below-knee amputation has not been previously described. We describe the surgical technique, including considerations and pearls in the amputee population, and particular technical tips related to the use of a fracture table and thin-wire femoral traction for optimum control of the residual limb.
Does intra-articular injection of adipose-derived stem cells improve cartilage mass? A case report on a 3D MRI quantitative evaluation of cartilage in knee osteoarthritis using SYNAPSE VINCENT: a case report
Authors: Kuwasawa Ayano , Nihei Kotaro 
Published: December 2020

Abstract
Background: Mesenchymal stem cells (MSC) are currently in focus because of the possibility of cartilage regeneration through several ways, including MSC sheets. However, there is no published report that visualizes cartilage in three dimensions. Here, we report a case of improved cartilage volume. We purified and cultured adipose-derived mesenchymal stem cells (ASC) and then performed ASC therapy by directly injecting these cells into the articular cartilage. Cartilage was quantitatively evaluated before and after injection using a three-dimensional (3D) image analysis software based on the MRI imagery.Case presentation: The patient, a 55-year-old woman, experienced pain in both knees and was diagnosed with osteoarthritis of the knee. We performed ASC therapy in both knees at our hospital and quantitatively evaluated cartilage before and after the treatment using the 3D image analysis software “SYNAPSE VINCENT”.Conclusions: For the quantitative analysis of cartilage, SYNAPSE VINCENT visualizes the state of cartilage in a high-definition 3D image, which is excellent for understanding the state of the disease and explaining it to the patient. Though there is room for debate about the reproducibility of errors, etc., SYNAPSE VINCENT would be useful as a clinical tool for regenerative medicine.
APLICAÇÃO DE FERRAMENTAS LEAN EM UMA INDÚSTRIA DE TRANSFORMAÇÃO DE PLÁSTICOS
Authors: Santos Bruno Sousa , Souza Santos Pedro Vieira 
Published: December 2020

A indústria de plásticos cresce com a globalização, trazendo novas perspectivas produtivas, e o aumento do consumo e da concorrência exige das empresas uma melhor utilização dos seus recursos. Este artigo teve como objetivo apresentar um estudo de caso de como uma organização pode desenvolver uma formulação objetiva e prática para eliminar desperdícios em uma indústria de plásticos. Tal formulação baseia-se em utilizar ferramentas do Lean Manufacturing. Através da análise e solução de problemas verificou-se a possibilidade de implementar a gestão visual e a padronização das tarefas. Após tais modificações, observou-se inicialmente um ganho substancial em comparação com configuração anterior. Após implantação das melhorias foi alcançado à redução significativa dos desperdícios no processo. Através da análise dos dados dos resultados obtidos, verificou-se uma resposta positiva à proposta inicial. Podemos concluir que com a adoção das novas configurações foram obtidos ganhos de produtividade, redução de tempo de produção e aumento de eficiência do processo.
Importance of BODIPY-based Chemosensors for Cations and Anions in Bio-imaging Applications
Authors: Kursunlu Ahmed Nuri , Bastug Elif , Guler Ersin 
Published: December 2020

Background:Chemosensor compounds are useful for sensitive selective detection of cations and anions with fluorophore groups in an attempt to develop the effective selectivity of the sensors. Although familiar fluorescent sensors utilizing inter-molecular interactions with the cations and anions, an extraordinary endeavor was executed the preparation of fluorescent-based sensor compounds. 4,4-difluoro-4- bora-3a,4a-diaza-s-indacene (Bodipy) and its derivatives were firstly used as an agent in the imaging of biomolecules due to their interesting structures, complexation, and fluorogenic properties. Among the fluorescent chemosensors used for cations and anions, Bodipy-based probes stand out owing to the excellent properties such as sharp emission profile, high stability, etc. In this review, we emphasize the Bodipy-based chemosensor compounds, which have been used to image cations and anions in living cells, because of as well as the biocompatibility and spectroscopic properties.Methods:Research and online content related to chemosensor online activity is reviewed. The advances, sensing mechanisms and design strategies of the fluorophore exploiting selective detection of some cation and anions with Bodipy-based chemosensors are explained. It could be claimed that the using of Bodipy-based chemosensors is very important for cations and anions in bio-imaging applications.Results:Molecular sensors or chemosensors are molecules that show a change can be detected when affected by the analyte. They are capable of producing a measurable signal when they are selective for a particular molecule. Molecular and ion recognition that it is important in biological systems such as enzymes, genes, environment, and chemical fields. Due to the toxic properties of many heavy metal ions, it is of great importance to identify these metals due to their harmful effects on living metabolism and the pollution they create in the environment. This process can be performed with analytical methods based on atomic absorption and emission. The fluorescence methods among chemosensor systems have many advantages such as sensitivity, selectivity, low price, simplicity of using the instrument and direct determination in solutions. The fluorescence studies can be applied at nanomolar concentrations.Conclusion:During a few decades, a lot of Bodipy-based chemosensors for the detection of cations & anions have been investigated in bio-imaging applications. For the Bodipy-based fluorescent chemosensors, the Bodipy derivatives were prepared by different ligand groups for the illumination of the photophysical and photochemical properties. The synthesized Bodipy-based chemosensors have remarkable photophysical properties, such as a high quantum yield, strong molar absorption coefficient etc. Moreover, these chemosensors were successfully implemented on living organisms for the detection of analytes.
Challenges to Antiretroviral Therapy Adherence and Coping Strategies to Overcome Them: Qualitative Investigations of Adolescents Living with HIV, their Caregivers, and Clinicians in Vietnam
Authors: Sabin Lora L. , Nguyen Vu Cong , Harvey Kelsee , Bonawitz Rachael , Hai Le Thanh , Van Lam Nguyen , Yen Le Thi , Gifford Allen L. , Haberer Jessica E. , Linh Dang Thuy , DeSilva Mary Bachman 
Published: December 2020

Background:
Adolescents living with HIV (ALHIV) in Vietnam are known to struggle with adherence to Antiretroviral Therapy (ART).

Objective:
To examine treatment challenges and facilitators experienced by ALHIV from the perspective of adolescents, their caregivers, and providers, and to inform an adherence intervention.

Methods:
In-depth Interviews (IDIs) of adolescent/caregiver dyads and Focus Group Discussions (FGDs) with adolescents, caregivers, and clinicians were conducted in Hanoi, Vietnam. We used semi-structured guides to encourage open-ended responses. We queried the challenges adolescents experience taking ART medications and being adherent, their awareness of disease status, and facilitators to support high adherence. Audio-recorded IDIs were translated into English, and coded and analyzed in NVivo using a thematic approach.

Results:
A total of 78 individuals participated in the study. Forty individuals participated in IDIs (20 adolescents and 20 caregivers). All adolescents had acquired HIV perinatally. We conducted six FGDs: four with adolescents, and one each with caregivers and clinicians. We identified major themes regarding awareness of HIV status (most caregivers reported they had disclosed to their child, while few adolescents revealed the knowledge of their status); perceived barriers to adherence (medication-related challenges, stigma, school-associated issues, financial obstacles, system challenges, awareness of HIV status); and adherence facilitators (development of dose-taking habits, reminder systems, social support). Differences between adolescents and caregivers related to key issues were evident.

Conclusion:
Further research is needed to elucidate discrepancies in adolescent-caregiver viewpoints and develop interventions tailored to both ALHIV and their caregivers.
COVID-19 Pandemic: Physical Activity as Prevention Mean
Authors: Hammami Nadhir , Jdidi Hela , Frih Bechir 
Published: December 2020

Background:
The consequences of the new pandemic caused by the Coronavirus Disease 2019 (COVID-19) have ruined the whole world. To date, more than 180 countries have been affected with more than 13 million people afflicted of all categories (young people, the elderly, athletes, and children) and more than 500,000 deaths around the globe. Moderate-intensity physical activity should be recommended as a non-pharmacological, low-cost, and feasible mean to cope with the COVID-19 virus

Objective:
The first objective is to provide an overview of the COVID-19 pandemic along with the evolution of this disease, the modes of inter-persons transmission, and the symptoms. The second objective is to suggest means of prevention for people, including the practice of regular physical activity.

Conclusion:
No drugs or treatments exist until today. The solution remains confinement in order to minimize contact between people (social distancing) and the strengthening of the immune system through a healthy lifestyle (healthy food and regular physical and sports practice) in addition to the recommended preventive measures.
Gene Expression of GSK3 in Type II Diabetics Compared to Non-Diabetics (ex vivo)
Authors: Khorami Somayeh A.H. , Mutalib Mohd S. Abd , Shiraz Mohammad F. , Abdullah Joseph A. , Rejali Zulida , Ali Razana M. , Khaza’ai Huzwah 
Published: December 2020

Background:

GSK3 is a serine/threonine kinase that is involved in the storage of glucose into glycogen through the negative regulation of glycogen synthase. Defects in GSK3 and glycogen synthase function are early stages of the development of insulin resistance, which may cause impaired glycogen synthesis in Type II diabetes.

Methods:
In this cross-sectional study, the gene expression level of GSK3 from Type II diabetic and non-diabetic participants was compared via real-time RT-PCR. To investigate the relationships between GSK3 expression and indicators of insulin resistance, Pearson's correlation analysis was performed. To compare the differences between GSK3 expression levels based on BMI categories, one-way ANOVA was used.

Results:
Gene expression of GSK3 was slightly higher in diabetic participants compared to non-diabetics, but it was statistically insignificant. Also, no significant difference was found based on BMI categories in the two groups. No significant association between GSK3 expression and indicators of insulin resistance was observed in non-diabetic participants. There was only a positive significant correlation between GSK3 expression and FBS in diabetic participants.

Conclusion:
These results indicate that the regulation of GSK3 may occur at the translation level, as gene expression level was unaltered between diabetic and non-diabetic participants. Also, since circulating levels of both glucose and insulin regulate GSK3 activity, tissue specificity for the expression and post-translation regulations of GSK3 may exist, which cause hyperactivation or overexpression in some target tissues in diabetes. Furthermore, it is probable that glycogen synthase activity is also regulated by non-insulin mediated mechanisms like exercise or allosteric changes, independent of GSK3 expression.
Lantana undulata Schrank – A New Source of Biological Potential in the
Verbenaceae Family
Authors: Ascendino D.M.S , T.L Barreto , C.E.D Igídio , J.O Castro , J.S.P Sousa , G.M Henriques , M.S Melo , L.D Silva , R.A Oliveira , F.F Oliveira , S.C.O Melo , E.L.A Malpezzi-Marinho , A.O Conceição 
Published: December 2020

Background :
The presence of condensed tannins, flavonones, flavonols, flavones, xantones,
catechins and alkaloids in the ethanolic extract of Lantana undulata leaves has been associated
with cytotoxicity and virucidal effect on suid herpesvirus.

Objective:
To evaluate cellular toxicity, antimicrobial and antioxidant activities, and anti-phlogistic
property of the ethanolic extract leaves of Lantana undulata, a plant from the Verbenaceae family.

Method:
Cytotoxicity was evaluated on Madin Darby bovine kidney (MDBK) cells and erythrocytes
and through leukocyte DNA damage. Antibacterial and antifungal activities were performed
using the agar diffusion technique and broth microdilution. The inhibition percentage and viral inhibition
index were established against bovine herpesvirus. The antioxidant effect (EC50) was determined
by the DPPH technique and the mouse ear edema model was used to determine the anti-phlogistic
activity.

Results:
The maximum nontoxic concentration for MDBK cells was 650 μg/ml. The ethanolic extract
of L. undulata was considered non-hemolytic from 2 to 16 μg/ml and not genotoxic at the concentration
tested (<8 μg/ml). High concentrations (3500 μg/ml) were needed to inhibit bacteria and
yeasts, and the action of the extract was bacteriostatic or fungistatic. The IIV was of 0.37 and the
IP was of 57.34% against bovine herpesvirus. The antioxidant EC50 was 540.87 μg/ml and the reduction
of oedema occurred at 10, 30 and 100 mg/kg in the mouse model used.

Conclusion:
Although the ethanolic extract of L. undulataleaves showed to be potentially toxic
and to have a reduced spectrum of action on microorganisms, the outstanding antiphlogistic action
puts the therapeutic potential of this plant into perspective.