bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managers’ regulatory focus, temporal focus and exploration–exploitation activities
Authors: Tuncdogan Aybars , Dogan Ismail Cagri 
Published: January 2020

PurposeThe purpose of this paper is to examine and gain further insight into the potential link between regulatory focus and exploration–exploitation at the individual manager level. More specifically, the authors hypothesised that temporal focus would act as a mediator in the relationship between managers’ regulatory foci and exploration–exploitation activities.Design/methodology/approachA survey was conducted with 541 managers from the USA. The model was tested using OLS regression models, followed by bootstrapped multiple-mediation analyses.FindingsManagers’ promotion and prevention foci are associated with the extent to which they focus on the past, the present and the future, which is related to managers’ exploration and exploitation activities.Research limitations/implicationsThe findings rely on self-report data.Practical implicationsThis paper examines the chronic strategic tendencies of managers with different levels of promotion and prevention focus – in particular, the timeframes they are likely to focus on and exploration–exploitation levels they are likely to engage in. In doing so, this paper provides managers a way to detect and overcome their chronic strategic shortcomings.Originality/valueThis paper not only examines the link between regulatory focus and exploration–exploitation at the individual level, but also provides further insights regarding the nature of this relationship. More specifically, by putting forward temporal focus as a mediator of this relationship, this study contributes to the ongoing discussion about the potential link between regulatory focus and exploration–exploitation, and poses new questions for future research.
Brand engagement and experience in online services
Authors: Khan Imran , Hollebeek Linda D. , Fatma Mobin , Islam Jamid Ul , Rahman Zillur 
Published: January 2020

Purpose
The purpose of this study is to assess the mediating role of brand trust and commitment in the relationship of brand engagement and brand experience with brand loyalty in the online service context.

Design/methodology/approach
To achieve the study’s objective, 414 users of virtual service brands, predominantly in the online banking, airline and hotel sectors, were surveyed.

Findings
Both brand engagement and experience exert direct effects on brand trust and commitment, as well as indirect effects on brand commitment (via brand trust) and service brand loyalty (via brand commitment).

Research limitations/implications
This paper adds to the literature by incorporating brand engagement, experience, trust and commitment into a unifying framework. The framework emphasizes brand trust and commitment’s mediating role in the relationship that brand engagement and experience share with brand commitment and loyalty in the online service context.

Practical implications
Marketers should formulate online brand engagement and experience strategies that strengthen customer brand trust and commitment, which are expected to exert a significant brand loyalty-enhancing effect.

Originality/value
Brand engagement and experience were validated as key drivers of brand trust and commitment, thereby further substantiating their role as important strategic metrics. Moreover, the role of commitment as a mediating factor in the association between brand engagement and experience and their respective impact on brand loyalty has been verified. Although the findings suggest that improved brand engagement/experience contributes to brand loyalty, this effect transpires only though brand commitment.
A novel cost allocation method applying fuzzy DEMATEL technique
Authors: Mirzamohammadi Saeed , Karimi Saeed , Pishvaee Mir Saman 
Published: January 2020

Purpose
The purpose of this paper is to develop a new systematic method for a multi-unit organization to cope with the cost allocation problem, which is an extension of the reciprocal method. As uncertainty is the inherent characteristic of business environments, assuming changes in engaged parameters is almost necessary. The outputs of the model determine the total value of each unit/business lines or product.

Design/methodology/approach
In the proposed method, contrary to existing models, business units are able to transfer their costs to other units, and also, not necessarily transfer the total costs of support units completely. The DEMATEL approach, which finds all relationships between different parts of a system, is also applied for computing effects of the units’ expense paid to each other. Moreover, a fuzzification approach is used to capture linguistic experts’ judgments about related data.

Findings
Being closer to the real-world problem in comparison to the previous approach, the proposed systematic approach encompasses the other cost allocation models.

Practical implications
Applying the proposed model for a system like a multi-unit organization, the total price of each unit/business line can be obtained. Moreover, this cost allocation process guides the related decision-makers to better manage the expenses that each unit pays the others.

Originality/value
In the existing studies, business units cannot pay expense support units. However, in the proposed method, the business units are able to pay expenses for other units, and also, not necessarily pay total expenses for support unit completely. Moreover, considering engaged parameters as fuzzy numbers makes the proposed model closer to real-world problems.
Generational differences in technology behaviour: comparing millennials and Generation X
Authors: Calvo-Porral Cristina , Pesqueira-Sanchez Rogelio 
Published: January 2020

Purpose
There are differences in the motivations underlying technology behaviour in each generational group; and there may be variances in the way each generational group uses and gets engaged with technology. In this context, this study aims to address the following questions: “Does generational cohort influence technology behaviour?” and if so: “What are the main motivations underlying Millennials and Generation X technology behaviour?”.

Design/methodology/approach
For this purpose, based on the uses and gratifications theory this study examines technology behaviour through multi-group structural equation modelling, drawing on a sample of 707 millennials and 276 Generation X individuals

Findings
Research findings indicate that millennials mostly use and get engaged with technologies for entertainment and hedonic purposes; while Generation X individuals are mainly driven by utilitarian purposes and information search. Further, research findings indicate the moderating role of generational cohort in the use of technologies.

Originality/value
This study provides empirical evidence of the main differences and motivations differences driving technology behaviour of millennials and Generation X individuals.
Effects of anaesthesia‐induced hypotension and phenylephrine on plasma volume expansion by hydroxyethyl starch: A randomised controlled study
Authors: Kaneko Takahiko , Tatara Tsuneo , Hirose Munetaka 
Published: January 2020

BackgroundChanges in blood haemoglobin concentration indicate plasma volume expansion following hydroxyethyl starch (HES) infusion, but may be affected by vascular tone and HES‐induced shedding of the endothelial surface layer (ESL). We hypothesised that anaesthesia‐induced hypotension enhances changes in plasma volume as assessed by blood haemoglobin concentration (ΔPVHb, %) following HES infusion.MethodsFifty‐two patients undergoing abdominal surgery were randomised to receive a continuous infusion of saline (S group) or phenylephrine to restore vascular tone (P group) (n = 26 each). Both groups received an infusion of 8 mL/kg 6% HES solution after induction of general anaesthesia. We compared ΔPVHb at the end of fluid infusion (15 minutes) and 15 minutes later (30 minutes) between the two groups. We assessed changes in ESL structure by measuring plasma concentrations of hyaluronate and syndecan‐1. P < .05 was considered statistically significant.ResultsMean arterial blood pressure was lower in the S group approximately by 30‐40% compared to the P group (P < .001). ΔPVHb was larger in the S group compared to the P group at 15 minutes (24.9 [5.2] % vs 19.0 [5.2] %; P < .001) and 30 minutes (26.5 [5.9] % vs 16.9 [6.6] %; P < .001). There were no clinically significant differences in plasma concentrations of hyaluronate and syndecan‐1 with time and between the groups.ConclusionsIncreased volume expansion of circulating plasma following HES infusion in anaesthesia‐induced hypotension compared to when blood pressure is restored by phenylephrine may result from an attenuation of transcapillary fluid filtration, rather than ESL shedding.UMIN Clinical Trial Registration Number: UMIN000017394 (http://www.umin.ac.jp/ctr/index.htm).
Compliance with follow‐up Test of Cure and outcomes after treatment for high‐grade cervical intraepithelial neoplasia in Victoria, Australia
Authors: Tan Jeffrey H.J. , Malloy Michael J. , Brotherton Julia M.L. , Saville Marion 
Published: January 2020

BackgroundTest of Cure (ToC), a combination of testing for oncogenic human papillomavirus (HPV) and cytology, at 12 months post‐treatment and annually thereafter, was approved in Australia in 2005 for follow‐up of women treated for high‐grade squamous intraepithelial lesions (HSIL) of the cervix.AimsTo determine among women resident in Victoria, Australia, the compliance with ToC and the incidence of recurrence up to five years after successful ToC.Materials and MethodsA retrospective analysis of women with HSIL (diagnosed at pre‐treatment punch biopsy or at excision) who had excisional treatment between 1 January 2007 and 31 December 2011. De‐identified data were retrieved from the Victorian Cervical Cytology Registry in Melbourne as at 24 April, 2015. Successful ToC is defined as the occurrence of two consecutive normal (negative) co‐tests. Recurrence after treatment is defined by histologically detected HSIL or greater.ResultsThere were 8478 women who had excisional treatment for HSIL, with 448 (5.5%) experiencing recurrence. Only 2253 (26.6%) women successfully completed ToC, with a decreasing likelihood of ToC completion by time since year of treatment (32.0% in 2007 compared with 20.9% in 2011). Only one (0.08%) woman had HSIL on histology after successful ToC. From the 2007 cohort, 555 (32.0%) women completed ToC successfully and no HSIL recurrence occurred thereafter (median subsequent follow‐up period of 4.7 years).ConclusionsOur study confirmed that women who successfully complete ToC can be returned to five‐year routine screening. However, more concerted efforts are needed to ensure that all women treated complete ToC.
Downside beta and the cross section of equity returns: A decade later
Authors: Atilgan Yigit , Demirtas K. Ozgur , Gunaydin A. Doruk 
Published: January 2020

AbstractThis study reexamines the relation between downside beta and equity returns in the United States. First, we replicate the 2006 work of Ang, Chen, and Xing who find a positive relation between downside beta and future equity returns for equal‐weighted portfolios of NYSE stocks. We show that this relation doesn't hold after using value‐weighted returns or controlling for various return determinants. We also extend the original sample, add AMEX/NASDAQ stocks or utilize alternative downside beta measures and still find no downside risk premium. We focus on factor analysis results, persistence of downside beta, and various subsamples to understand the economic reasons behind the findings.
Climate change fingerprints in recent European plant phenology
Authors: Menzel Annette , Yuan Ye , Matiu Michael , Sparks Tim , Scheifinger Helfried , Gehrig Regula , Estrella Nicole 
Published: January 2020

AbstractA paper published in Global Change Biology in 2006 revealed that phenological responses in 1971–2000 matched the warming pattern in Europe, but a lack of chilling and adaptation in farming may have reversed these findings. Therefore, for 1951–2018 in a corresponding data set, we determined changes as linear trends and analysed their variation by plant traits/groups, across season and time as well as their attribution to warming following IPCC methodology. Although spring and summer phases in wild plants advanced less (maximum advances in 1978–2007), more (~90%) and more significant (~60%) negative trends were present, being stronger in early spring, at higher elevations, but smaller for nonwoody insect‐pollinated species. These trends were strongly attributable to winter and spring warming. Findings for crop spring phases were similar, but were less pronounced. There were clearer and attributable signs for a delayed senescence in response to winter and spring warming. These changes resulted in a longer growing season, but a constant generative period in wild plants and a shortened one in agricultural crops. Phenology determined by farmers’ decisions differed noticeably from the purely climatic driven phases with smaller percentages of advancing (~75%) trends, but farmers’ spring activities were the only group with reinforced advancement, suggesting adaptation. Trends in farmers’ spring and summer activities were very likely/likely associated with the warming pattern. In contrast, the advance in autumn farming phases was significantly associated with below average summer warming. Thus, under ongoing climate change with decreased chilling the advancing phenology in spring and summer is still attributable to warming; even the farmers’ activities in these seasons mirror, to a lesser extent, the warming. Our findings point to adaptation to climate change in agriculture and reveal diverse implications for terrestrial ecosystems; the strong attribution supports the necessary mediation of warming impacts to the general public.
HDAC1 and HDAC2 regulate anti‐inflammatory effects of anesthetic isoflurane in human monocytes
Authors: Guo Xinying , Deng Jie , Zheng Bin , Liu Hao , Zhang Yuehong , Ying Yanlu , Jia Jie , Ruan Xiangcai 
Published: January 2020

AbstractPre‐exposure to volatile anesthetics inhibits inflammation induced by various stimuli, including surgical procedures and ischemia. We hypothesize that volatile anesthetics may induce anti‐inflammatory effects via a mechanism involving regulation of histone deacetylases (HDACs). Pre‐exposure of 1.5% isoflurane for 0.5 h induced anti‐inflammatory effects [measured by cytokine production of tumor necrosis factor‐ɑ, interleukin‐8 (IL‐8) and IL‐1β] in both human THP‐1 cells and primary human peripheral blood monocytes stimulated by lipopolysaccharide. In human THP‐1 cells, coadministration of the HDAC inhibitor trichostatin A (TSA) blocked the isoflurane‐induced anti‐inflammatory effects. TSA also blocked isoflurane‐upregulated HDAC1‒3 expression and isoflurane‐reduced nuclear translocation of p65 and p50 subunits of nuclear factor‐κB (NF‐κB). The ability of isoflurane to reduce NF‐κB nuclear translocation and proinflammatory responses in the cell line was blocked by gene silencing ofHDAC1andHDAC2, but not by gene silencing ofHDAC3. A coimmunoprecipitation assay demonstrated that the decreased interaction between HDAC1 and HDAC2 through lipopolysaccharide was restored by isoflurane pretreatment. These findings were validated in primary human peripheral blood monocytes wherein gene silencing ofHDAC1andHDAC2resulted in increased cytokine production and NF‐κB nuclear translocation induced by isoflurane pre‐exposure and lipopolysaccharide stimulation. These results indicate that anti‐inflammatory effects of the volatile anesthetic isoflurane in human monocytes involve regulation of HDAC1 and HDAC2.
Stack ensembled model to measure size and mass of almond kernels
Authors: Vidyarthi Sriram K. , Tiwari Rakhee , Singh Samrendra K. 
Published: January 2020

AbstractAfter harvesting almond crop, accurate measurement of almond kernel sizes is a significant specification to plan, develop and enhance almond processing operations. The size and mass of the individual almond kernels are vital parameters usually associated with almond quality and yield. In this study, we propose a novel methodology that combines image processing and machine‐learning ensemble that accurately measures the size and mass of whole raw almond kernels (classification—Nonpareil) simultaneously. We have developed an image‐processing algorithm using recursive method to identify the individual almond kernels from an image and estimate the size of the kernels based on the occupied pixels by a kernel. The number of pixels representing an almond kernel was used as its digital fingerprint to predict its size and mass. Various popular machine learning (ML) models were implemented to build a stacked ensemble model (SEM), predicting the mass of the individual almond kernels based on the features derived from the pixels of the individual kernels in the image. The prediction accuracy and robustness of image processing and SEM were analyzed using uncertainty quantification. The mean error in estimating the average length of 1,000 almond kernel was 3.12%. Similarly, mean errors associated with predicting the 1,000 kernel mass were 0.63%. The developed algorithm in almond imaging in this study can be used to facilitate a rapid almond yield and quality appraisals.
Marked heterogeneity in the diagnosis of compensated cirrhosis of patients with chronic hepatitis C virus infection in a real‐world setting: A large, multicenter study from Japan
Authors: Toyoda Hidenori , Atsukawa Masanori , Watanabe Tsunamasa , Nakamuta Makoto , Uojima Haruki , Nozaki Akito , Takaguchi Koichi , Fujioka Shinichi , Iio Etsuko , Shima Toshihide , Akahane Takehiro , Fukunishi Shinya , Asano Toru , Michitaka Kojiro , Tsuji Kunihiko , Abe Hiroshi , Mikami Shigeru , Okubo Hironao , Okubo Tomomi , Shimada Noritomo , Ishikawa Toru , Moriya Akio , Tani Joji , Morishita Asahiro , Ogawa Chikara , Tachi Yoshihiko , Ikeda Hiroki , Yamashita Naoki , Yasuda Satoshi , Chuma Makoto , Tsutsui Akemi , Hiraoka Atsushi , Ikegami Tadashi , Genda Takuya , Tsubota Akihito , Masaki Tsutomu , Iwakiri Katsuhiko , Kumada Takashi , Tanaka Yasuhito , Okanoue Takeshi 
Published: January 2020

AbstractBackground and AimThe presence of cirrhosis is an important factor for the management of patients with hepatitis C virus (HCV) infection and it determines the duration of treatment for HCV with the direct‐acting antiviral (DAA) regimen of glecaprevir (GLE) and pibrentasvir (PIB), that is, 8 or 12 weeks, if patients do not have a history of DAA failure. However, in real‐world settings, determination of cirrhosis depends on the discretion of the attending hepatologists, and it is unclear whether compensated cirrhosis was homogenously diagnosed or not. In this study, we investigated the real‐world diagnosis of cirrhosis by characterizing DAA‐naïve patients who underwent a 12‐week GLE/PIB regimen in whom cirrhosis was diagnosed, comparing their characteristics with those of patients who underwent an 8‐week regimen in whom cirrhosis was absent.MethodsIn a large, multicenter cohort study, we compared background characteristics and treatment outcomes among DAA‐naïve patients who underwent an 8‐week versus a 12‐week GLE/PIB regimen.ResultsAmong 977 patients enrolled, 296 (30.3%) were determined to have cirrhosis and underwent a 12‐week regimen. Some patient characteristics largely overlapped between the two groups, including liver fibrosis indices. Sustained viral response rates were similar between groups after adjusting liver fibrosis index with propensity score matching.ConclusionAlthough adequately diagnosed, the determination of cirrhosis varied widely among institutions or by hepatologists in real‐world settings, and the severity of liver fibrosis overlapped significantly between patients in whom compensated cirrhosis was determined to be present and patients in whom cirrhosis was absent. Virologic efficacy was similar after adjusting for the degree of liver fibrosis.
Comparison of preference mapping with projective mapping for characterizing consumer perception of brewed black coffees
Authors: Harwood William S. , McLean Kyle G. , Ennis John M. , Ennis Daniel M. , Drake MaryAnne 
Published: January 2020

AbstractThis study compared projective mapping (PM) with check‐all‐that apply (CATA) with 24 consumers to traditional preference mapping with 257 consumers for evaluation of drivers of liking for brewed black coffees. For the PM exercise, black coffee consumers (n = 24) evaluated 11 coffees and placed them on a two‐dimensional plane based on similarities and then selected attributes from a provided list (PMCATA) to describe each coffee. These consumers also scored liking of each coffee. PMCATA and liking evaluations were completed in duplicate. A trained descriptive analysis (DA) panel (n = 8) documented properties of the coffees in quadruplicate and black coffee consumers (n = 257) were recruited for traditional consumer acceptance testing. Landscape segmentation analysis (LSA) was applied to trained panel data and consumer acceptance scores. Data from the PMCATA exercise was analyzed using multiple factor analysis (MFA). Consumer groups from the PMCATA exercise were differentiated by preferences for light or dark roast attributes. Similarly, determination of ideal points by LSA revealed that consumer groups were defined primarily by differences in preference for different roast types and roast‐related attributes. Based on the similarities in regard to product characterization and consumer segmentation, these results demonstrate that PMCATA can be an effective preliminary alternative to traditional methods for profiling and consumer preferences of complex products like coffee.Practical applicationDescriptive analysis (DA) and consumer acceptance testing for preference mapping can be time and cost intensive. This study demonstrates that projective mapping, combined with check‐all‐that‐apply (PMCATA) profiling by consumers, can be used as a rapid method for understanding a product landscape and acceptability of products with particular attributes. It is unlikely that PMCATA will replace preference mapping practices; however, it might serve as an effective alternative for researchers and developers when time or budget is constrained, or as an initial screening step for understanding a product category.
PINOID regulates floral organ development by modulating auxin transport and interacts with MADS16 in rice
Authors: Wu Hua‐Mao , Xie Dong‐Jiang , Tang Zuo‐Shun , Shi Dong‐Qiao , Yang Wei‐Cai 
Published: January 2020

SummaryIn rice (Oryza sativa L.), floral organ development is an important trait. Although a role for PINOID in regulating floral organ development was reported recently, the underlying molecular mechanism remains unclear. Here, we isolated and characterized an abnormal floral organ mutant and mapped the causative gene through an improved MutMap method. Molecular study revealed that the observed phenotype is caused by a point mutation in OsPINOID (OsPID) gene; therefore, we named the mutation as ospid‐4. Our data demonstrate that OsPID interacts with OsPIN1a and OsPIN1b to regulate polar auxin transport as shown previously. Additionally, OsPID also interacts with OsMADS16 to regulate transcription during floral organ development in rice. Together, we propose a model that OsPID regulates floral organ development by modulating auxin polar transport and interaction with OsMADS16 and/or LAX1 in rice. These results provide a novel insight into the role of OsPID in regulating floral organ development of rice, especially in stigma development, which would be useful for genetic improvement of high‐yield breeding of rice.