bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of data analytics strategies in computer vision systems to predict pig body composition traits from 3D images
Authors: Fernandes Arthur F A , Dórea João R R , Valente Bruno Dourado , Fitzgerald Robert , Herring William , Rosa Guilherme J M 
Published: August 2020

AbstractComputer vision systems (CVS) have been shown to be a powerful tool for the measurement of live pig body weight (BW) with no animal stress. With advances in precision farming, it is now possible to evaluate the growth performance of individual pigs more accurately. However, important traits such as muscle and fat deposition can still be evaluated only via ultrasound, computed tomography, or dual-energy x-ray absorptiometry. Therefore, the objectives of this study were: 1) to develop a CVS for prediction of live BW, muscle depth (MD), and back fat (BF) from top view 3D images of finishing pigs and 2) to compare the predictive ability of different approaches, such as traditional multiple linear regression, partial least squares, and machine learning techniques, including elastic networks, artificial neural networks, and deep learning (DL). A dataset containing over 12,000 images from 557 finishing pigs (average BW of 120 ± 12 kg) was split into training and testing sets using a 5-fold cross-validation (CV) technique so that 80% and 20% of the dataset were used for training and testing in each fold. Several image features, such as volume, area, length, widths, heights, polar image descriptors, and polar Fourier transforms, were extracted from the images and used as predictor variables in the different approaches evaluated. In addition, DL image encoders that take raw 3D images as input were also tested. This latter method achieved the best overall performance, with the lowest mean absolute scaled error (MASE) and root mean square error for all traits, and the highest predictive squared correlation (R2). The median predicted MASE achieved by this method was 2.69, 5.02, and 13.56, and R2 of 0.86, 0.50, and 0.45, for BW, MD, and BF, respectively. In conclusion, it was demonstrated that it is possible to successfully predict BW, MD, and BF via CVS on a fully automated setting using 3D images collected in farm conditions. Moreover, DL algorithms simplified and optimized the data analytics workflow, with raw 3D images used as direct inputs, without requiring prior image processing.
Fentanyl and Driving Impairment
Authors: Rohrig Timothy P , Nash Emily , Osawa Kei A , Shan Xiaoqin , Scarneo Colleen , Youso Kimberly B , Miller Russell , Tiscione Nicholas B 
Published: August 2020

Abstract
The incidence of fentanyl in forensic toxicology analyses in the USA has dramatically increased over the past several years. The increase in death cases has been well studied; however, little has been reported on the impact to drug impaired driving. Fentanyl driving while under the influence of drugs (DUID) case data from 2014 to 2019 is presented. The data were obtained from three toxicology laboratories in the Northeast, Southeast, and Midwest regions of the USA. Fentanyl whole blood concentrations ranged from 0.1 to 157 ng/mL in living drivers with a 466% to 524% increase in fentanyl-positive DUID cases from 2014 to 2019, depending on the US region. The vast majority of fentanyl cases involved poly-drug use. Twenty case histories are presented where fentanyl was the only drug identified. The mean (standard deviation) fentanyl concentration for these cases was 5.2 ± 3.8 ng/mL with a median of 3.7 ng/mL, and the concentrations ranged from 2.0 to 16 ng/mL. Naloxone administration was documented in exactly half of these cases similar to another study involving carfentanil-impaired driving. The case histories also demonstrate that some recreational opioid users may display limited signs of impairment either due to tolerance or naloxone administration. The top three observations in common among the cases were the driver was found unresponsive behind the wheel, the vehicle left the travel lane or roadway, and the driver was involved in a crash. The increase in fentanyl use not only poses a risk for overdose and death, but is also a significant concern for traffic safety. This study supports the movement of fentanyl from a Tier II drug to Tier I due to its significant potential for impairment and increase in prevalence in impaired driving cases.
Acquired ATRX Loss and ALT Phenotype Through Tumor Recurrences in a Case of Pleomorphic Xanthoastrocytoma Suggest Their Possible Roles in Tumor Progression
Authors: Dal Col Pierre , Poncet Delphine , Rivoirard Romain , Vassal François , Bernichon Emilie , Boutet Claire , Péoc’h Michel , Forest Fabien 
Published: August 2020

Abstract
Pleomorphic xanthoastrocytoma (PXA) is classified as an astrocytic glioma occurring most often in children or young adults. Molecular alterations in PXA are not fully known, especially those associated with tumor progression. We describe a patient with several relapses of a PXA. The tumor showed an acquired ATRX loss through tumor evolution. We tested alternative lengthening of telomeres (ALT) with the C-circle test. While the test was negative in the first tumor, a high circle activity was detected in the last relapse, suggesting an acquired ALT phenotype. Our data not only confirm previous findings of the possible occurrence of ATRX mutations in PXA but also suggest that this alteration is linked to PXA progression. In small biopsies, tumors with ATRX loss, without IDH or histone mutation, pathologists should consider the diagnosis of PXA, especially if associated with BRAF V600E mutation, CDKN2A deletion, and ALT.
Large lipoma of the ascending colon: a case report and review of literature
Authors: Farfour Aya N , AbuOmar Noor A , Alsohaibani Fahad I 
Published: August 2020

Abstract
Gastrointestinal lipomas are a rare benign non-epithelial neoplasms derived from mature adipocytes. The colon is the commonest organ involved in the entire digestive tract and has an incidence rate ~4.4% in autopsy series. Most of the colonic lipomas are asymptomatic and incidentally detected. Lipomas need to be distinguished from true neoplasia, because in most cases they do not need to be resected unless when they cause a clear symptom or they are large in size. Surgical rather than endoscopic resection is preferred for lipomas &gt; 2 cm to avoid complications such as bleeding and perforation. We report a case of a 56-year-old female, a known case of locally advanced breast cancer and positive adenomatous polyposis coli mutation, who was found to have 4 cm ascending colon lipoma by imaging and confirmed by colonoscopy and histopathology.
X-ray emission from hot gas in galaxy groups and clusters in simba
Authors: Robson Dylan , Davé Romeel 
Published: August 2020

ABSTRACT
We examine X-ray scaling relations for massive haloes ($M_{500}\gt 10^{12.3}\, \mathrm{M}_\odot$) in the simba galaxy formation simulation. The X-ray luminosity, LX versus M500 has power-law slopes ${\approx }\frac{5}{3}$ and ${\approx }\frac{8}{3}$ above and below $10^{13.5} \, \mathrm{M}_{\odot }$, deviating from the self-similarity increasingly to low masses. TX − M500 is self-similar above this mass, and slightly shallower below it. Comparing simba to observed TX scalings, we find that LX, LX-weighted [Fe/H], and entropies at 0.1R200 (S0.1) and R500 (S500) all match reasonably well. S500 − TX is consistent with self-similar expectations, but S0.1 − TX is shallower at lower TX, suggesting the dominant form of heating moves from gravitational shocks in the outskirts to non-gravitational feedback in the cores of smaller groups. simba matches observations of LX versus central galaxy stellar mass M*, predicting the additional trend that star-forming galaxies have higher LX(M*). Electron density profiles for $M_{500}\gt 10^{14}\, \mathrm{M}_\odot$ haloes show a ∼0.1R200 core, but the core is larger at lower masses. TX are reasonably matched to observations, but entropy profiles are too flat versus observations for intermediate-mass haloes, with Score ≈ 200–400 keV cm2. simba’s [Fe/H] profile matches observations in the core but overenriches larger radii. We demonstrate that Simba’s bipolar jet AGN feedback is most responsible for increasingly evacuating lower-mass haloes, but the profile comparisons suggest this may be too drastic in the inner regions.
Structural and mechanistic insights into the CRISPR inhibition of AcrIF7
Authors: Kim Iktae , Koo Jasung , An So Young , Hong Suji , Ka Donghyun , Kim Eun-Hee , Bae Euiyoung , Suh Jeong-Yong 
Published: August 2020

Abstract
The CRISPR–Cas system provides adaptive immunity for bacteria and archaea to combat invading phages and plasmids. Phages evolved anti-CRISPR (Acr) proteins to neutralize the host CRISPR–Cas immune system as a counter-defense mechanism. AcrIF7 in Pseudomonas aeruginosa prophages strongly inhibits the type I-F CRISPR–Cas system. Here, we determined the solution structure of AcrIF7 and identified its target, Cas8f of the Csy complex. AcrIF7 adopts a novel β1β2α1α2β3 fold and interacts with the target DNA binding site of Cas8f. Notably, AcrIF7 competes with AcrIF2 for the same binding interface on Cas8f without common structural motifs. AcrIF7 binding to Cas8f is driven mainly by electrostatic interactions that require position-specific surface charges. Our findings suggest that Acrs of divergent origin may have acquired specificity to a common target through convergent evolution of their surface charge configurations.
Does dietary potassium intake associate with hyperkalemia in patients with chronic kidney disease?
Authors: Ramos Christiane I , González-Ortiz Ailema , Espinosa-Cuevas Angeles , Avesani Carla M , Carrero Juan Jesus , Cuppari Lilian 
Published: August 2020

Abstract

Background
Dietary potassium restriction is a strategy to control hyperkalemia in chronic kidney disease (CKD). However, hyperkalemia may result from a combination of clinical conditions. This study aimed to investigate whether dietary potassium or the intake of certain food groups associate with serum potassium in the face of other risk factors.

Methods
We performed a cross-sectional analysis including a nondialysis-dependent CKD (NDD-CKD) cohort and a hemodialysis (HD) cohort. Dietary potassium intake was assessed by 3-day food records. Underreporters with energy intake lower than resting energy expenditure were excluded. Hyperkalemia was defined as serum potassium &gt;5.0 mEq/L.

Results
The NDD-CKD cohort included 95 patients {median age 67 [interquartile range (IQR) 55–73] years, 32% with diabetes mellitus (DM), median estimated glomerular filtration rate 23 [IQR 18–29] mL/min/1.73 m2} and the HD cohort included 117 patients [median age 39 (IQR 18–67) years, 50% with DM]. In NDD-CKD, patients with hyperkalemia (36.8%) exhibited lower serum bicarbonate and a tendency for higher serum creatinine, a higher proportion of DM and the use of renin–angiotensin–aldosterone system blockers, but lower use of sodium bicarbonate supplements. No association was found between serum and dietary potassium (r = 0.01; P = 0.98) or selected food groups. Conditions associated with hyperkalemia in multivariable analysis were DM {odds ratio [OR] 3.55 [95% confidence interval (CI) 1.07–11.72]} and metabolic acidosis [OR 4.35 (95% CI 1.37–13.78)]. In HD, patients with hyperkalemia (50.5%) exhibited higher serum creatinine and blood urea nitrogen and lower malnutrition inflammation score and a tendency for higher dialysis vintage and body mass index. No association was found between serum and potassium intake (r = −0.06, P = 0.46) or food groups. DM [OR 4.22 (95% CI 1.31–13.6)] and serum creatinine [OR 1.50 (95% CI 1.24–1.81)] were predictors of hyperkalemia in multivariable analyses.

Conclusions
Dietary potassium was not associated with serum potassium or hyperkalemia in either NDD-CKD or HD patients. Before restricting dietary potassium, the patient’s intake of potassium should be carefully evaluated and other potential clinical factors related to serum potassium balance should be considered in the management of hyperkalemia in CKD.
A single-cell transcriptome atlas of the aging human and macaque retina
Authors: Yi Wenyang , Lu Yufeng , Zhong Suijuan , Zhang Mei , Sun Le , Dong Hao , Wang Mengdi , Wei Min , Xie Haohuan , Qu Hongqiang , Peng Rongmei , Hong Jing , Yao Ziqin , Tong Yunyun , Wang Wei , Ma Qiang , Liu Zeyuan , Ma Yuqian , Li Shouzhen , Yin Chonghai , Liu Jianwei , Ma Chao , Wang Xiaoqun , Wu Qian , Xue Tian 
Published: August 2020

Abstract
The human retina is a complex neural tissue that detects light and sends visual information to the brain. However, the molecular and cellular processes that underlie aging primate retina remain unclear. Here, we provide a comprehensive transcriptomic atlas based on 119,520 single cells of the foveal and peripheral retina of humans and macaques covering different ages. The molecular features of retinal cells differed between the two species, suggesting the distinct regional and species specializations of the human and macaque retinae. In addition, human retinal aging occurred in a region- and cell-type- specific manner. Aging of human retina exhibited a foveal to peripheral gradient. MYO9A− rods and a horizontal cell subtype were greatly reduced in aging retina, indicating their vulnerability to aging. Moreover, we generated a dataset showing the cell-type- and region- specific gene expression associated with 55 types of human retinal disease, which provides a foundation to understand the molecular and cellular mechanisms underlying human retinal diseases. Together, these datasets are valuable for understanding the molecular characteristics of primate retina, as well as the molecular regulation of aging progression and related diseases.
Separating singular moduli and the primitive element problem
Authors: Bilu Yuri , Faye Bernadette , Zhu Huilin 
Published: August 2020

Abstract
We prove that ${|x-y|\ge 800X^{-4}}$, where $x$ and $y$ are distinct singular moduli of discriminants not exceeding $X$. We apply this result to the ‘primitive element problem’ for two singular moduli. In a previous article, Faye and Riffaut show that the number field ${{\mathbb{Q}}}(x,y)$, generated by two distinct singular moduli $x$ and $y$, is generated by ${x-y}$ and, with some exceptions, by ${x+y}$ as well. In this article we fix a rational number ${\alpha \ne 0,\pm 1}$ and show that the field ${{\mathbb{Q}}}(x,y)$ is generated by ${x+\alpha y}$, with a few exceptions occurring when $x$ and $y$ generate the same quadratic field over ${{\mathbb{Q}}}$. Together with the above-mentioned result of Faye and Riffaut, this generalizes a theorem due to Allombert et al. (2015) about solutions of linear equations in singular moduli.
Sleep–wake regulation in preterm and term infants
Authors: Georgoulas Anastasis , Jones Laura , Laudiano-Dray Maria Pureza , Meek Judith , Fabrizi Lorenzo , Whitehead Kimberley 
Published: August 2020

AbstractStudy ObjectivesIn adults, wakefulness can be markedly prolonged at the expense of sleep, e.g. to stay vigilant in the presence of a stressor. These extra-long wake bouts result in a heavy-tailed distribution (highly right-skewed) of wake but not sleep durations. In infants, the relative importance of wakefulness and sleep are reversed, as sleep is necessary for brain maturation. Here, we tested whether these developmental pressures are associated with the unique regulation of sleep–wake states.MethodsIn 175 infants of 28–40 weeks postmenstrual age (PMA), we monitored sleep–wake states using electroencephalography and behavior. We constructed survival models of sleep–wake bout durations and the effect of PMA and other factors, including stress (salivary cortisol), and examined whether sleep is resilient to nociceptive perturbations (a clinically necessary heel lance).ResultsWake durations followed a heavy-tailed distribution as in adults and lengthened with PMA and stress. However, differently from adults, active sleep durations also had a heavy-tailed distribution, and with PMA, these shortened and became vulnerable to nociception-associated awakenings.ConclusionsSleep bouts are differently regulated in infants, with especially long active sleep durations that could consolidate this state’s maturational functions. Curtailment of sleep by stress and nociception may be disadvantageous, especially for preterm infants given the limited value of wakefulness at this age. This could be addressed by environmental interventions in the future.
Preparing for a Joint Commission Survey: An Innovative Approach to Learning
Authors: Campbell Rebeka Watson , Leger J. Michael 
Published: August 2020

Abstract
Graduate nurses report feeling unprepared for accreditation site visits, including the promotion of a safe, functional, supportive environment to preserve safety and quality through the provision of care, treatment, and services for patients. To address this gap, an academic health system’s department of quality and a school of nursing collaborated on a three-phase capstone course for senior-level BSN students. The course included simulation training for all students; volunteers performed Environment of Care rounds and patient care record audits in the hospital setting. Nineteen students, who performed 74 rounds and 193 audits, reported feeling more knowledgeable during site visits.
Redesigning Nursing Education to Build Healthier Communities: An Innovative Cross-Sector Collaboration
Authors: Swan Beth Ann , Hilden Peggy , West Nikki , Chan Garrett , Shaffer Kathryn , Berg Judith G. , Dickow Mary , Jones Deloras 
Published: August 2020

Abstract
Today’s health care environment requires registered nurses to be prepared for an array of practice settings, providing care outside the hospital and directly in the community. There is increasing focus on wellness, prevention, access to care, and mental health services for an aging and more diverse population. To improve alignment of education with increasingly complex needs, donor-advised funding supported four prelicensure nursing schools to transform their curricula. Selected schools were guided through a curriculum redesign process emphasizing community and continuum of care. This innovation was consistent with meeting challenges to realize the Institute of Medicine’s 2011 Future of Nursing recommendations.
Population Health Beyond the Classroom: An Innovative Approach to Educating Baccalaureate Nursing Students
Authors: Ruiz Diana 
Published: August 2020

Abstract
An increasingly diverse population warrants an innovative and transformational educational approach to prepare the baccalaureate nurse to practice and lead. This article describes an innovation for teaching population health to meet complex community health needs and provide interprofessional collaborative opportunities and diverse leadership experiences. Course revision for clinical and didactic courses included the incorporation of cross-sector and interdisciplinary collaboration in the community, along with a strong emphasis on social determinants of health.
Ophthalmic manifestations and management of common and rare autoimmune syndromes
Authors: Seol Young , Lee Roxanne , Bielory Brett P. 
Published: August 2020

Purpose of review
This article reviews the ocular findings in patients with a myriad of autoimmune syndromes. This review will provide guidance and heighten awareness for the allergist or eye care provider to pay heed to the manifestations and treatments of autoimmune syndromes.

Recent findings
Autoimmune syndromes can present with varied manifestations on the ocular surface known to potentially cause significant visual morbidity. In particular, sterile corneal ulcers are the most devastating and common finding in uncontrolled autoimmune disease. Ophthalmic manifestations of autoimmune syndromes have been reported individually; however, herein we present a comprehensive review of typical and atypical syndromes that may present with sterile corneal ulceration.

Summary
Autoimmune inflammatory syndromes are known to be associated with ocular surface inflammatory processes ranging from bothersome dry eye syndromes to vision-threatening sterile corneal ulceration. It is important to pay heed to the clinical presentation of common and uncommon presentations of the syndromes in the eye. We propose best practice for management of ocular surface disease in these clinical entities.
Hymenoptera venom-induced anaphylaxis and hereditary alpha-tryptasemia
Authors: O’Connell Michael P. , Lyons Jonathan J. 
Published: August 2020

Purpose of reviewTo discuss the association between the common dominantly inherited genetic trait hereditary alpha-tryptasemia (HαT) and hymenoptera venom-induced anaphylaxis (HVA).Recent findingsElevated BST has been correlated with more severe systemic anaphylaxis in humans in a number of settings – most notably in HVA. Clonal mast cell disease, in particular, systemic mastocytosis, is frequently associated with elevated BST, and is a major risk factor for severe HVA. However, clonal mast cell diseases are believed to be rare, whereas HVA is relatively more common. HαT affects an estimated 3–5% of Western populations and is the common cause for elevated BST in these individuals. An association between HαT and severe HVA, as well as clonal mast cell disease has recently been demonstrated wherein this trait modifies reaction severity in venom allergic individuals. A mechanism underlying this association has been proposed through the identification of naturally occurring heterotetrameric tryptases and characterization of their unique physical attributes.SummaryHere we discuss the long-standing association between elevated BST and HVA severity, how HαT fits into this landscape, and review the clinical and mechanistic evidence that supports HαT as a modifier of HVA.
Advances in allergen immunotherapy for asthma
Authors: Agache Ioana , Laculiceanu Alexandru , Cojanu Catalina , Spanu Daniela , Rogozea Liliana 
Published: August 2020

Purpose of review
Allergen immunotherapy (AIT) is a well-known disease-modifying intervention for allergic diseases. Its benefit in allergic asthma, ranging from prevention to facilitating asthma control, is yet to be clarified.

Recent findings
In 2017, following several well-designed randomised controlled trials (RCTs) with house-dust mites (HDM) sublingual (SLIT) tablets in asthma, global initiative for asthma (GINA) guidelines highlighted the need to treat the allergic component of asthma. In 2019, the European Academy of Allergy and Clinical Immunology published the first comprehensive guidelines for HDM AIT in allergic asthma, formulating separate recommendations for subcutaneous, SLIT drops, and SLIT tablets. Significant steps were undertaken in understanding the mechanisms of allergic asthma, facilitating the stratified approach for selecting responders and in translating the immune-modulation effect in achieving long-term control of the chronic inflammation in asthma.

Summary
Currently existing guidelines recommend AIT as a therapeutic option in controlled or partially controlled HDM allergic asthma. Limited data are available for pollen, molds and pets, as well as for the severe allergic asthma population. The challenge for the future research will be to clarify the subendotypes of allergic asthma responding to AIT, the mechanisms facilitating its’ preventive and disease-modifying effect, the optimal duration of the treatment, and route of administration.