bluuebunny/crossref_metadata_2025_split huggingface dataset:
P061 Perianal Involvement in Crohn's Disease: Are There Always Two Sides to Every Coin?
Authors: Magalhaes Rui , Xavier Sofia , Dias de Castro Francisca , Moreira Maria João , Cotter José 
Published: December 2019

BACKGROUND:
Crohn's disease (CD) is complicated with perianal disease in 21-23% of patients. Presence of perianal disease has been associated with a disabling course of CD and dreadful impact on quality of life. We aim to identify if perianal disease has negative implication on CD remission rates, after one-year infliximab therapy course.

METHODS:
Cohort, retrospective, single center study, including consecutive CD patients on Infliximab perfusion. Patients were followed one year, since the beginning of biological therapy. Co-variables were chosen bearing in mind clinical relevance and literature evidence. We split our outcome variable into clinical remission; analytical remission; endoscopic remission and deep remission (including all three mentioned before). The correlation towards the outcome variable was assessed with univariate and multivariate analysis, and a survival assessment, using SPSS – P value < 0.05 was considered statistically significant.

RESULTS:
We assessed 74 patients with CD, of whom 41 (55,4%) were female, with a mean age of 36 years old, all Caucasian. From our cohort, 36.5% of the patients presented perianal disease at diagnosis. After one year of treatment course, we documented 31.5% of deep remission, 47.2% endoscopic remissions, 55.4% analytical remission and 70.3% of clinical remission. Sixty-six patients (89.2%) presented any type of initial response to the treatment, from whom, 20 presented disease relapses (clinical or/and analytical or/and endoscopic). Patients with perianal disease, on the first year of Infliximab therapy, have a higher probability of disease relapse, displaying statistically significant difference on Kaplan-Meyer curves (Breslow P-value 0.043). Several variables had statistical significance towards the outcomes on the univariate analysis (age at diagnosis; disease behavior at diagnosis; smoking; hospital admission; days of hospital stay; corticoid cycle; biological naïve patients; blood infliximab levels; calprotectin, protein c reactive, erythrocyte sedimentation rate levels before and after one year of follow up). Adjusting for confoundment, patients with perianal disease have an odd 7.6 times higher of achieving endoscopic remission (P-value 0.038) and 17 times higher of achieving clinical remission (P-value 0.019) with infliximab therapy.

CONCLUSION(S):
In CD patients on infliximab therapy, perianal disease involvement is associated with higher endoscopic, analytical and clinical remission rates, after one year follow up. However, they are more prone to disease relapse, in the first year of biological therapeutic.
P095 The Very Interesting Small Bowel Lesions of Cronkhite-Canada Syndrome
Authors: Tanaka Akihito , Kanmura Shuji , Yutsudo Kazuki , Komaki Yuga , Iwaya Hiromichi , Arima Shiho , Sasaki Fumisato , Tanoue Shiroh , Hashimoto Shinichi , Ido Akio 
Published: December 2019

BACKGROUND:
Cronkhite-Canada syndrome (CCS) is a non-hereditary disease characterized by the presence of gastrointestinal polyposis and skin symptoms such as hair loss, nail plate atrophy, and skin pigmentation. Approximately 50% of cases of CCS also have small bowel lesions. However, there have been few image reports of the small intestine lesions.

METHODS:
We examined the findings of small intestine capsule endoscopy (CE) in 3 cases of CCS in our hospital.

RESULTS:
Case 1 was of a 64-year-old male whose chief complaint was diarrhea, abnormal taste, and weight loss. He had diarrhea for 2 months and aware of finger pigmentation and nail atrophy. Esophagogastroduodenoscopy (EGD) revealed a collection of reddish polyps that expanded in the stomach and duodenum, and colonoscopy (CS) revealed glossy reddish bumps in the colon. CE showed diffuse reddish, edematous mucosa and villi enlargement in the entire small bowel. From these characteristic endoscopic and skin findings, he was diagnosed with CCS and was started on prednisolone (PSL) treatment. The treatment response was good, and there was no relapse. Case 2 was of a 65-year old female whose chief complaint was skin pigmentation. She had been aware of pigmentation on her back, palms, and upper arms, and loss of fingernails for the last 6 years with repeated disappearances and exacerbations. Furthermore, erosive gastritis and gastric hyperplastic polyps had been detected 4 years ago, and she was followed-up for these symptoms. Gradually, she became aware of nausea and loose stools, which prompted her to visit our hospital. EGD and CS revealed multiple reddish polyps predominantly in the gastric antrum, villous atrophy and reddish polyps in the terminal ileum, and scattered reddish polyps in the entire colon. Mucosal biopsies revealed glandular dilation, mucosal edema, and inflammatory cell infiltration. CE showed diffuse mulberry ridges and villi atrophy throughout the small bowel. She was diagnosed with CCS based on characteristic clinical and endoscopic findings, and was started on steroid treatment. There was no relapse. Case 3 was of a 75-year old male whose chief complaint was diarrhea and hair loss. EGD and CS revealed multiple polyps in the stomach, duodenum, and colon. CE showed reddish edematous mucosa and villi mixed with atrophy and swelling in the small bowel. Of note were that these findings were found in the jejunum. He was diagnosed with CCS and started on PSL and immunomodulator. Four years later, the characteristic findings disappeared in the CE.

CONCLUSION(S):
All patients had lesions in the entire small bowel, but there they were not associated with clinical findings or steroid response. The mucosa of the small intestine were more likely to have various findings as the period from onset to diagnosis became longer.
P100 Using Data Aggregation to Determine Thematic Knowledge Transfer and Lasting Performance Change in Multiple Continuing Education Activities on IBD
Authors: Faler Whitney , Perez Jan , Tordoff Sharon , Salinas Greg , Gross Tara 
Published: December 2019

BACKGROUND:
Often, implications of the effect of CME is difficult to determine due to reliance on single data points of pre-post knowledge questions. Using aggregation methodology, we were able to thematically combine the assessments of 3 similar educational activities to determine the immediate and lasting effect of education on IBD practice.

METHODS:
Surveys were designed based on learning objectives of 3 accredited CME activities on IBD. Outcomes measurements were taken directly before and after the activities, as well as 3-months after activity completion. This 3-month follow-up sample was matched at the same time to a control sample of clinicians who did not participate in the education.

RESULTS:
Based on the themes of the pre-post questions, we were able to aggregate the scores of the three activities and determine overall changes in understanding key risk factors, establishing appropriate goals, choice of guideline-based therapy, and knowledge of clinical trials. Compared to pre-activity, learners had significant improvements in each of these areas, showing effectiveness of the education. Hodge’s g effect sizes were run on all pre-post data to better compare the effect of education across themes. The most robust effects were seen in recognizing risk factors (g = 0.75) and clinical trial results (g = 0.71) while more modest effects were seen in establishing goals of treatment (g = 0.40) and selecting treatment (g = 0.59). Some of this modest effect seen in establishing goals can be attributed to a high baseline level of knowledge (a pre-score of 70.8%). However, looking at the scores of learners compared to a control group of similar clinicians that did not attend the education, robust effects can be seen even 30 days after the activity. Assessment of risk had an effect of 0.67 while establishing goals (g = 0.81) and treatment choice (g = 0.85) had even higher effects.

CONCLUSION(S):
Aggregating the outcomes of multiple educational activities allows us to understand effect by theme, providing opportunities to inform key stakeholders of the value of educational interventions. Further it allows educators opportunities to understand the continuing need of the community that has not attended these activities, and focus future interventions on improving areas where they are needed most.
Aspectos psicosociales en el proceso de inclusión educativa durante la infancia intermedia
Authors: Campa Álvarez Reyna de los Ángeles , Contreras Cázarez Carlos René 
Published: December 2019

El objetivo principal del presente trabajo es analizar los aspectos psicosociales: actitudes, cultura de la diversidad y práctica docente; para determinar su relación en el proceso de inclusión educativa en las escuelas primarias públicas del Estado de Sonora, México. Se empleó una metodología cuantitativa de tipo descriptivo- correlacional, se aplicó el cuestionario- escala sobre la integración e inclusión de personas con necesidades educativas y diversas (Gento, 2007), a una muestra de 285 profesores de educación primaria del Estado de Sonora, México. Para el análisis de datos se utilizó el programa estadístico SPSS, versión 21, y el programa EQS versión 6.1, obteniendo datos de fiabilidad, descriptivos, correlaciones y el modelo estructural. Los resultados indican que el modelo planteado en su conjunto predice un 64% la inclusión educativa. Se puede concluir que las actitudes se relacionan recíprocamente con la cultura, afectando significativamente a la práctica docente; siendo elementos claves en el proceso de inclusión educativa.
Transmission of Cleruchic Land: A Model to Describe the Procedure
Authors: Schubert Paul 
Published: December 2019

Abstract
The first rulers of the Ptolemaic dynasty granted cleruchic land to their soldiers. The process by which this category of land was transmitted from one holder to the next was strictly controlled. The precise procedure of transfer can be reconstructed on the basis of documents dating from the Ptolemaic and Roman period. An attempt is made here to provide a synthetic model for this procedure, and to highlight the difference between the Ptolemaic and Roman periods.
Tourism tensions and sociolinguistic change
Authors: Jaworski Adam 
Published: December 2019

AbstractThe articles in the present special issue,Tourism spaces at the nexus of language and materiality, are commented on through the lens of “sociolinguistic change” (Coupland 2014), and four pairs of relations:modernity and tradition;de- and re-centering of languages;elite and mass tourism;profit and prejudice. Brief concluding remarks touch on the relationship between the symbolic and material aspects of language.
Distributed control of networked systems with coupling constraints
Authors: Liu Zonglin , Stursberg Olaf 
Published: December 2019

Abstract
This paper proposes algorithms for the distributed solution of control problems for networked systems with coupling constraints. This type of problem is practically relevant, e. g., for subsystems which share common resources, or need to go through a bottleneck, while considering non-convex state constraints. Centralized solution schemes, which typically first cast the non-convexities into mixed-integer formulations that are then solved by mixed-integer programming, suffer from high computational complexity for larger numbers of subsystems. The distributed solution proposed in this paper decomposes the centralized problem into a set of small subproblems to be solved in parallel. By iterating over the subproblems and exchanging information either among all subsystems, or within subsets selected by a coordinator, locally optimal solutions of the global problem are determined. The paper shows for two instances of distributed algorithms that feasibility as well as continuous cost reduction over the iterations up to termination can be guaranteed, while the solutions times are considerably shorter than for the centralized problem. These properties are illustrated for a multi-vehicle motion problem.
New Ways of Being Church: The Promise of Fresh Expressions
Authors: Martin Robert K. 
Published: December 2019

Abstract
In 2006, British Anglicans and Methodists organized an evangelical initiative called Fresh Expressions to start experimental faith communities. The target population was people who are not involved in church. Over the past 13 years, Fresh Expressions has expanded to almost every continent as a movement that holds together traditional, inherited church practices with entrepreneurial experimentation. It has been lauded as an incarnational approach to mission and it has been criticized for colluding with the worst of contemporary culture. This essay explores the historical development of Fresh Expressions, its unique integral approach to ecclesiology, and its potential for ecclesial renewal and reform.
Tripsazea, a Novel Trihybrid of Zea mays, Tripsacum dactyloides, and Zea
perennis
Authors: Yan Xu , Cheng Mingjun , Li Yingzheng , Wu Zizhou , Li Yang , Li Xiaofeng , He Ruyu , Yang Chunyan , Zhao Yanli , Li Huaxiong , Wen Xiaodong , Zhang Ping , Sam Ebenezer , Rong Tingzhao , He Jianmei , Tang Qilin 
Published: December 2019

Abstract
A trispecific hybrid, MTP (hereafter called tripsazea), was developed from intergeneric crosses involving tetraploid Zea mays (2n = 4x = 40, genome: MMMM), tetraploid Tripsacum dactyloides (2n = 4x = 72, TTTT), and tetraploid Z. perennis (2n = 4x = 40, PPPP). On crossing maize-Tripsacum (2n = 4x = 56, MMTT) with Z. perennis, 37 progenies with varying chromosome numbers (36-74) were obtained, and a special one (i.e., tripsazea) possessing 2n = 74 chromosomes was generated. Tripsazea is perennial and expresses phenotypic characteristics affected by its progenitor parent. Flow cytometry analysis of tripsazea and its parents showed that tripsazea underwent DNA sequence elimination during allohexaploidization. Of all the chromosomes in diakinesis I, 18.42% participated in heterogenetic pairing, including 16.43% between the M- and P-genomes, 1.59% between the M- and T-genomes, and 0.39% in T- and P-genome pairing. Tripsazea is male sterile and partly female fertile. In comparison with previously synthesized trihybrids containing maize, Tripsacum and teosinte, tripsazea has a higher chromosome number, higher seed setting rate, and vegetative propagation ability of stand and stem. However, few trihybrids possess these valuable traits at the same time. The potential of tripsazea is discussed with respect to the deployment of the genetic bridge for maize improvement and forage breeding.
Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification
Authors: Smith Keriayn N , Miller Sarah C , Varani Gabriele , Calabrese J Mauro , Magnuson Terry 
Published: December 2019

Abstract
Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is strongly dependent on identifying determinants of cell identity. Long noncoding RNAs (lncRNAs) have been shown to regulate cellular plasticity, including pluripotency establishment and maintenance, differentiation and development, yet broad phenotypic analysis and the mechanistic basis of their function remains lacking. As components of molecular condensates, lncRNAs interact with almost all classes of cellular biomolecules, including proteins, DNA, mRNAs, and microRNAs. With functions ranging from controlling alternative splicing of mRNAs, to providing scaffolding upon which chromatin modifiers are assembled, it is clear that at least a subset of lncRNAs are far from the transcriptional noise they were once deemed. This review highlights the diversity of lncRNA interactions in the context of cell fate specification, and provides examples of each type of interaction in relevant developmental contexts. Also highlighted are experimental and computational approaches to study lncRNAs.
Miopatías autoinmunes: revisión de diagnóstico y manejo
Authors: Bertorini Tulio , Meza Kelly , Chunga Natalia 
Published: December 2019

Las miopatías inflamatorias idiopáticas (MII) son un grupo de enfermedades autoinmunes crónicas que afectan principalmente a los músculos proximales. Los tipos más comunes son dermatomiositis (DM), polimiositis (PM), miopatía autoinmune necrotizante y miositis por cuerpos de inclusión. Se identifican de forma única por su presentación clínica que consiste en manifestaciones musculares y extramusculares, sus alteraciones miopáticas en el electromiograma y la elevación de las enzimas musculares. Sin embargo, la biopsia muscular sigue siendo el gold estándar para el diagnóstico. Estos trastornos son potencialmente tratables con un diagnóstico adecuado. Los objetivos del tratamiento son eliminar la inflamación, restaurar el rendimiento muscular, reducir la morbilidad y mejorar la calidad de vida. Esta revisión tiene como objetivo proporcionar un enfoque de diagnóstico básico a los pacientes con sospecha de MMI a través de sus principales hallazgos clínicos, de laboratorio e histopatológicos.
Miasis oral nosocomial en una unidad de cuidados intensivos
Authors: Gutierrez Alejandro 
Published: December 2019

Presentamos un caso de miasis nosocomial ocurrido en un hospital peruano, cuyo agente etiológico identificado fue Cochliomyia hominivorax, en un paciente de 82 años que estuvo internado en una unidad de cuidados intensivos por insuficiencia respiratoria aguda tipo I, y sepsis por absceso hepático, el cual fue sometido a intubación para brindarle respiración mecánica asistida. Al tercer día de ingreso a UCI se observó presencia de múltiples larvas maduras de tercer estadio en cavidad oral. El tratamiento consistió en la extracción manual de las larvas y terapia de ivermectina a razón de 0,2 miligramos por kilogramo de peso con respuesta favorable. Al mes de ser diagnosticado de miasis el paciente fallece por complicaciones de sepsis hepática y neumonía.
Stability of Nuclear Reactor: Point Model Analysis
Authors: Bučys K. , Švitra D. 
Published: December 2019

A point model of a nuclear reactor with delay in feedback line “ower – reactivity” estimating the influence of six groups of delayed neutrons is presented and investigated by means of linear and nonlinear analysis methods. The results of numerical experiments and the comparison of them to the asymptotic solution of differential equations are presented as well.
Lie Group Analysis of Natural Convection Heat and Mass Transfer in an Inclined Surface
Authors: Sivasankaran S. , Bhuvaneswari M. , Kandaswamy P. , Ramasami E. K. 
Published: December 2019

Natural convection heat transfer fluid flow past an inclined semiinfinite surface in the presence of solute concentration is investigated by Lie group analysis. The governing partial differential equations are reduced to a system of ordinary differential equations by the translation and scaling symmetries. An exact solution is obtained for translation symmetry and numerical solutions for scaling symmetry. It is found that the velocity increases and temperature and concentration of the fluid decrease with an increase in the thermal and solutal Grashof numbers. The velocity and concentration of the fluid decrease and temperature increases with increase in the Schmidt number.
Non–β-Lactam Antibiotic Hypersensitivity Reactions
Authors: Grinlington Lisa , Choo Sharon , Cranswick Noel , Gwee Amanda 
Published: December 2019

OBJECTIVES:
Antibiotics are among the most common prescriptions in children, and non–β-lactam antibiotics (NBLAs) account for almost half of those prescribed in Australian pediatric hospitals. Despite this, data on NBLA hypersensitivity in children are limited. This study describes reported hypersensitivity reactions to NBLAs in children and the results of allergy evaluation.

METHODS:
Children with a suspected NBLA allergy who had skin testing and/or an intravenous or oral challenge test (OCT) between May 2011 and June 2018 were included. Patients were excluded if they were &gt;18 years old or did not complete the allergy evaluation for any reason other than allergic reaction.

RESULTS:
Over the 7-year study period, 141 children had 150 allergy evaluations of 15 different NBLAs. The median time from the initial reported reaction to allergy evaluation was 1.9 (range 0.1–14.9) years. Overall, 27 of the 150 (18.0%) challenge tests to NBLAs had positive results, with the rate of positive OCT results being highest for trimethoprim-sulfamethoxazole (15 of 46; 32.6%) and macrolides (8 of 77; 10.4%). Although 4 children reported initial anaphylactic reactions, no patients had severe symptoms on rechallenge or required adrenaline. Of the challenges that had positive results, the majority of children (23 of 27; 85.2%) had symptoms on repeat challenge similar to those that were initially reported.

CONCLUSIONS:
Overall, 8 of 10 children with NBLA allergy could be delabeled. On average, patients waited 1.9 years to be rechallenged. Timely access to allergy evaluation to delabel these patients is needed to preserve first-line antibiotics.
USE OF BACTERIA IN CANCER THERAPY (REVIEW)
Authors: Darmov I. V. , Kibirev Ya. A. , Marakulin I. V. , Yanov S. N. 
Published: December 2019

Bacterial drugs for the treatment of malignant tumors have been discovered more than a hundred years ago, but their use in clinical practice has been very limited. In the past decade, there has been a revival of interest in the development of bacterial-based cancer biotherapies, which is associated with advances in genetic engineering and in depth knowledge of the mechanisms of the infectious process and immunity. The purpose of this review is to examine the current state and prospects for the development and use of drugs based on live bacterium, intended for the treatment of malignant tumors. The review presents evaluation data on experimental models of the antitumor potential of various species and strains of bacteria; the most significant results of clinical trials of bacterial antitumor agents; current trends in the design of bacterial strains for targeted drug delivery to the tumor. It is concluded that development of bacterial drugs for cancer therapy is a perspective branch of experimental oncology.
State evolution and conception of the right to education as a fundamental right
Authors: Silva Maria Magalhaes , Alves Dora Resende 
Published: December 2019

The right to education as a fundamental right has followed the evolution of the democratic State and it can be found both at the level of the internal law of the States, in the constitutional texts and in international law. It appears in the Constitution of the Portuguese Republic of 1976, inserted in the economic, social and cultural rights and is consecrated in the European Union. Always as a value associated with the rule of law and democracy.Through a methodology with literature revision of portuguese national legal texts and of the EU law it is possible to analyze the progress achieved historically towards the impletation of the education as a fundamental right.
Keywords: education; fundamental right; European Union.