bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic controller tuning using a zeroth-order optimization algorithm
Authors: Zalkind Daniel S. , Dall'Anese Emiliano , Pao Lucy Y. 
Published: November 2020

Abstract. We develop an automated controller tuning procedure for wind turbines that uses the results of nonlinear, aeroelastic simulations to arrive at an optimal solution.
Using a zeroth-order optimization algorithm, simulations using controllers with randomly generated parameters are used to estimate the gradient and converge to an optimal set of those parameters.
We use kriging to visualize the design space and estimate the uncertainty, providing a level of confidence in the result. The procedure is applied to three problems in wind turbine control.
First, the below-rated torque control is optimized for power capture.
Next, the parameters of a proportional–integral blade pitch controller are optimized to minimize structural loads with a constraint on the maximum generator speed; the procedure is tested on rotors from 40 to 400 m in diameter and compared with the results of a grid search optimization.
Finally, we present an algorithm that uses a series of parameter optimizations to tune the lookup table for the minimum pitch setting of the above-rated pitch controller, considering peak loads and power capture.
Using experience gained from the applications, we present a generalized design procedure and guidelines for implementing similar automated controller tuning tasks.
Génesis y evolución de la categoría realidad histórica en Ignacio Ellacuría
Authors: Brito Marcela 
Published: November 2020

The main objective of this work is to present a evolutionary proposal of Ignacio Ellacuría's thought from a strictly metaphysical perspective. For this, the exhibition will be held in three fundamental moments: youth (1951-1962), approach to Zubirian philosophy and maturity project (1962-1974) and historical reality as a moment of maturity (1975-1989). In each of them a discussion is held around the fundamental problems that mark the development of Ellacuría's complex thought, in order to arrive at his proposal of the civilizational change that marked the reflections of the last years of his life and understand, of fraud, how his thinking has a novel and current character in our national and planetary conjuncture.
Revista de Ciencias Sociales y Humanidades No. 155, 2020: 17-46
Diagnostic performance of 18F-DCFPyL positron emission tomography/computed tomography for biochemically recurrent prostate cancer and change-of-management analysis
Authors: Chaussé Guillaume , Ben-Ezra Noah , Stoopler Michelle , Levett Jeremy Y. , Niazi Tamim , Anidjar Maurice , Abikhzer Gad , Probst Stephan 
Published: November 2020

Introduction: Conventional imaging (CI) performs poorly to identify sites of disease in biochemically recurrent prostate cancer. 68Ga-PSMA-11 positron emission tomography/ computed tomography (PET/CT) is most studied but has a very short half-life. This study reports the diagnostic performance of the novel prostate-specific membrane antigen (PSMA) radiotracer 18F-DCFPyL using real-life data, and tumor board simulation to estimate the impact of 18F-DCFPyL PET on patient management.
Methods: Ninety-three 18F-DCFPyL PET/CT scans performed for patients previously treated for prostate cancer with a rising prostate-specific antigen (PSA) were retrospectively compared to contemporary CI, and clinical, imaging and PSA followups. A chart review was performed to document prior imaging, pathology results, serial serum PSA measurements, and other pertinent clinical data. Clinical utility of 18F-DCFPyL PET was measured using a simulated tumor board formed by three physicians with extensive prostate cancer experience deciding on management with and without knowledge of PET/CT results.
Results: At median PSA 2.27 (interquartile range [IQR] 5.27], 82% of 18F-DCFPyL PET/CT demonstrated at least one site of disease: non-regional lymph nodes (37% of scans), regional lymph node metastases (28%), local recurrence (27%), bone metastases (20%), with higher PET positivity at higher PSA. Compared to 18F-DCFPyL PET/CT, CI showed overall poor performance, with accuracy below 20% for all extent of disease. PET/CT changed management in 44% of cases. The most frequent scenario was a radical change from initiating androgen deprivation therapy (ADT) to stereotactic body radiotherapy (SBRT) of oligo-lesional disease. In univariate and multivariate analysis, no patient characteristic could predict change of management by PET/CT results.
Conclusions: 18F-DCFPyL significantly outperforms CI in recurring prostate cancer and is likely to impact management.
The development and efficacy of an interdisciplinary chronic pelvic pain program
Authors: Katz Laura , Fransson Adria , Patterson Lisa 
Published: November 2020

Introduction: Chronic pelvic pain (CPP) is a significant issue, and approximately 14% of women experience CPP once in their lifetime. While interdisciplinary pain management is considered the gold standard of treatment, few programs offer this type of treatment in Canada. The aims of this paper were to: 1) describe the development of an interdisciplinary CPP program; and 2) demonstrate changes in patient-related outcomes after attending an interdisciplinary CPP program.
Methods: Referrals were received from community urologists and obstetricians/gynecologists, and pain physicians at the Michael G. DeGroote Pain Clinic. Patients attended an orientation session, completed an interdisciplinary assessment, and if appropriate attended an eight-day interdisciplinary CPP program. Each day consisted of group-based pelvic floor physiotherapy, psycho-education, goal-setting, cognitive behavioral therapy, and mindfulness. Psychometric questionnaires were completed pre- and post-program by patients, and paired sample t-tests were used to evaluate the changes in patient-related outcomes after attending the program.
Results: Thirty-seven female patients completed the program, and results demonstrate that the CPP program was associated with significant improvements in impact of pelvic pain on quality of life, readiness for change, and pain-related self-efficacy, as well as decreases in pain catastrophizing and fear of pain/re-injury.
Conclusions: CPP is a complex condition that requires interdisciplinary management and care. The results of this study demonstrate the short-term benefits of an interdisciplinary CPP program and highlight the unique needs of women with CPP and implicate multiple factors for programming and treatment.
Intracranial Air Embolism after Inferior Alveolar Nerve Block: A Case Report
Authors: Gillespie Megan , Gunsolly Chad 
Published: November 2020

Introduction: The number of nontraumatic dental pain emergency department (ED) visits continues to substantially rise in frequency every year. While there are several methods for treating dental pain, an inferior alveolar nerve block (IANB) is a non-narcotic alternative that provides instantaneous relief of severe pain.

Case Report: A 59-year-old male presented to the ED from a dentist’s office for evaluation of a right-sided headache with an associated episode of palpitations and near syncope that developed while receiving an inferior alveolar nerve block. Computed tomography of the patient’s head revealed multiple small foci of air in the right temporalis muscle and in the intracranial venous drainage system. Given the patient’s history of dental procedure, the intravascular introduction of air and local anesthetic was suspected.

Conclusion: Inferior alveolar nerve block procedures can have complications, including hematoma formation, trismus, facial palsy, needle breakage, and in this case, intravascular injection and cerebral air embolism. To perform a successful IANB, it is critical for providers to be familiar with anatomical landmarks and to consistently perform aspiration to confirm that needle placement is not intravascular.
Gender distribution beyond coarse measurements
Authors: Duarte Melina , Kochanska Adrianna , Nustad Torill 
Published: November 2020

UiT The Arctic University of Norway has built a strong tradition of promoting gender balance within the institution. After decades of research and systematic measures, the university has increased the share of women in professor positions from 9% in 2000 to almost 40% in 2020. Today, UiT leads the national ranking in that category, being the university with highest representation of women in professor positions among the comprehensive Higher Education institutions in Norway. While this is a great achievement for the institution, Prestige Project calls, in this report, for a cautious interpretation of these results. While almost 40% of women hold professor positions at the university level, great disparities remain within and across knowledge fields and disciplines. A more nuanced view on the data shows that as of January 2020, 82% of the professor positions in the STEM fields at UiT were still held by men (NT and IVT Faculties combined). In addition, the overrepresentation of women in the fields commonly associated with female activities such as social sciences, care, and education have inflated the overall results for the better.
This report argues that the measurements of proportion of women and men in professor positions at the university level is a limited tool for a meaningful monitoring of gender balance in these positions at the university. This is because this metric does not allow for the monitoring of disparities within and across the different fields of knowledge and disciplines constituting the broad educational and research portfolio of the institution, neither for evaluating the effects of interventions at the units’ level. These limitations show that there is a need for more precise indicators for enabling the monitoring and evaluation of significant progress/deterioration in gender balance. In this perspective, a more precise metric can better serve as guidance for the generation of effective and more gender-aware management practices at the institution. Prestige Project proposes in this report an alternative metric that intends to better respond to this need: the scatterplot for gender balance in professor positions at UiT.
Anti-Streptococcus mutans and anti-biofilm activities of dextranase and its encapsulation in alginate beads for application in toothpaste
Authors: Juntarachot Nucharee , Sirilun Sasithorn , Kantachote Duangporn , Sittiprapaporn Phakkharawat , Tongpong Piyachat , Peerajan Sartjin , Chaiyasut Chaiyavat 
Published: November 2020

Background
The accumulation of plaque causes oral diseases. Dental plaque is formed on teeth surfaces by oral bacterial pathogens, particularly Streptococcus mutans, in the oral cavity. Dextranase is one of the enzymes involved in antiplaque accumulation as it can prevent dental caries by the degradation of dextran, which is a component of plaque biofilm. This led to the idea of creating toothpaste containing dextranase for preventing oral diseases. However, the dextranase enzyme must be stable in the product; therefore, encapsulation is an attractive way to increase the stability of this enzyme.

Methods
The activity of food-grade fungal dextranase was measured on the basis of increasing ratio of reducing sugar concentration, determined by the reaction with 3, 5-dinitrosalicylic acid reagent. The efficiency of the dextranase enzyme was investigated based on its minimal inhibitory concentration (MIC) against biofilm formation by S. mutans ATCC 25175. Box-Behnken design (BBD) was used to study the three factors affecting encapsulation: pH, calcium chloride concentration, and sodium alginate concentration. Encapsulation efficiency (% EE) and the activity of dextranase enzyme trapped in alginate beads were determined. Then, the encapsulated dextranase in alginate beads was added to toothpaste base, and the stability of the enzyme was examined. Finally, sensory test and safety evaluation of toothpaste containing encapsulated dextranase were done.

Results
The highest activity of the dextranase enzyme was 4401.71 unit/g at a pH of 6 and 37 °C. The dextranase at its MIC (4.5 unit/g) showed strong inhibition against the growth of S. mutans. This enzyme at 1/2 MIC also showed a remarkable decrease in biofilm formation by S. mutans. The most effective condition of dextranase encapsulation was at a pH of 7, 20% w/v calcium chloride and 0.85% w/v sodium alginate. Toothpaste containing encapsulated dextranase alginate beads produced under suitable condition was stable after 3 months of storage, while the sensory test of the product was accepted at level 3 (like slightly), and it was safe.

Conclusion
This research achieved an alternative health product for oral care by formulating toothpaste with dextranase encapsulated in effective alginate beads to act against cariogenic bacteria, like S. mutants, by preventing dental plaque.
Predicting disease occurrence of cabbage Verticillium wilt in monoculture using species distribution modeling
Authors: Ikeda Kentaro , Osawa Takeshi 
Published: November 2020

BackgroundAlthough integrated pest management (IPM) is essential for conservation agriculture, this method can be inadequate for severely infected fields. The ability to predict the potential occurrence of severe infestation of soil-borne disease would enable farmers to adopt suitable methods for high-risk areas, such as soil disinfestation, and apply other options for lower risk areas. Recently, researchers have used species distribution modeling (SDM) to predict the occurrence of target plant and animal species based on various environmental variables. In this study, we applied this technique to predict and map the occurrence probability of a soil-borne disease, Verticillium wilt, using cabbage as a case study.MethodsA disease survey assessing the distribution of Verticillium wilt in cabbage fields in Tsumagoi village (central Honshu, Japan) was conducted two or three times annually from 1997 to 2013. Road density, elevation and topographic wetness index (TWI) were selected as explanatory variables for disease occurrence potential. A model of occurrence probability of Verticillium wilt was constructed using the MaxEnt software for SDM analysis. As the disease survey was mainly conducted in an agricultural area, the area was weighted as “Bias Grid” and area except for the agricultural area was set as background.ResultsGrids with disease occurrence showed a high degree of coincidence with those with a high probability occurrence. The highest contribution to the prediction of disease occurrence was the variableroad densityat 97.1%, followed byTWIat 2.3%, andelevationat 0.5%. The highest permutation importance wasroad densityat 93.0%, followed byTWIat 7.0%, while the variableelevationat 0.0%. This method of predicting disease probability occurrence can help with disease monitoring in areas with high probability occurrence and inform farmers about the selection of control measures.
Perception among Future Healthcare Providers about Treatment and Management of ALS
Authors: Iqbal Muhammad Zahid , Khan Salah-Ud-Din , Saad Eldowaik Mohamed Salah , Iqbal Muhammad Shahid 
Published: November 2020

Objective: The objective of the study was to determine the perception of future healthcare providers regarding Amyotrophic Lateral Sclerosis (ALS) in a private medical university.
Methods: A cross-sectional study was conducted using a convenience sampling method. A self-developed and pre-validated tool was used to collect data from students studying in three health care faculties of a university in Malaysia. The Statistical Package for Social Science (SPSS) Version 24.0 was used to analyze the data.
Results: A total of 268 healthcare students from three faculties (medical, pharmacy and dental) participated in the current study More female students 183 (68.3%) participated than the male students 85 (31.7%) in current study.
Conclusion: Overall appropriate perception was observed among the studied future healthcare providers. The present study concluded that pharmacy students had more positive perception regarding ALS than the rest of the participants.
Identification of a 1,274‐bp promoter of a Musa acuminata L. aquaporin gene (MaPIP1;1) which confers salinity stress inducibility in transgenic Arabidopsis
Authors: Song Shun , Ma Funing , Huang Dongmei , Wu Bin , Ma Chaozhi , Li Jingyang , Li Yujia , Wei Qing , Sun Qiurong , Wang Wenquan , Xu Yi 
Published: November 2020

AbstractSalt stress will seriously influence alt stress in banana (Musa L.) induces MaPIP1;1, which enhances the salt resistance of transgenic Arabidopsis. The promoter pMaPIP1;1, located 13,62 bp upstream of the transcriptional start site, was isolated from the banana genome, and four pMaPIP1;1::GUS fusion constructs namely M‐P1, M‐P2, M‐P3, and M‐P4 were used to transform into Arabidopsis. In this work, in order to functionally verify the promoter responds to high salt stress, we used NaCl treatment for simulating salt terms. NaCl treatment is responded to by four transformants. M‐P2 (−1,274 bp to −1) showed the highest transcriptional activity among all transgenic Arabidopsis transformants. This area of the promoter endows high glucuronidase (GUS) enzyme activity according to NaCl treatment. These results will help us understand the transcriptional regulatory of MaPIP1;1, and promoter fragment M‐P2 will be an ideal candidate for overexpression of salt response genes to increase plant resistance.
Efficacy of direct hemoperfusion for the removal of phenobarbital through blood concentration analysis
Authors: Mizushima Shohei , Hirose Yousuke , Yuzawa Hiroko , Kimura Tomonori , Oguchi Moe , Morito Tomohiro , Sadahiro Tomohito 
Published: November 2020

AimPhenobarbital overdose can cause coma and even death. The consciousness disturbance is often prolonged due to its long half‐life. In this study, we investigated the efficacy of direct hemoperfusion (DHP) for the removal of phenobarbital by measuring the blood levels of phenobarbital.MethodsStudy subjects included five patients with phenobarbital poisoning who were transferred to our hospital. Direct hemoperfusion was carried out in three of the five patients (six times in total), and the elimination rate was calculated by measuring the blood levels before and after DHP. Furthermore, the disappearance rate of phenobarbital without DHP was calculated in all five patients (seven times in total) for comparison with the elimination rate.ResultsThe elimination rate of phenobarbital with DHP was significantly higher than the disappearance rate without DHP．ConclusionThis study suggests that early introduction of DHP should be considered as a treatment option for phenobarbital poisoning.
Network Fingerprint of Stimulation‐Induced Speech Impairment in Essential Tremor
Authors: Petry‐Schmelzer Jan Niklas , Jergas Hannah , Thies Tabea , Steffen Julia K. , Reker Paul , Dafsari Haidar S. , Mücke Doris , Fink Gereon R. , Visser‐Vandewalle Veerle , Dembek Till A. , Barbe Michael T. 
Published: November 2020

ObjectiveThis study was undertaken to gain insights into structural networks associated with stimulation‐induced dysarthria (SID) and to predict stimulation‐induced worsening of intelligibility in essential tremor patients with bilateral thalamic deep brain stimulation (DBS).MethodsMonopolar reviews were conducted in 14 essential tremor patients. Testing included determination of SID thresholds, intelligibility ratings, and a fast syllable repetition task. Volumes of tissue activated (VTAs) were calculated to identify discriminative fibers for stimulation‐induced worsening of intelligibility in a structural connectome. The resulting fiber‐based atlas structure was then validated in a leave‐one‐out design.ResultsFibers determined as discriminative for stimulation‐induced worsening of intelligibility were mainly connected to the ipsilateral precentral gyrus as well as to both cerebellar hemispheres and the ipsilateral brain stem. In the thalamic area, they ran laterally to the thalamus and posteromedially to the subthalamic nucleus, in close proximity, mainly anterolaterally, to fibers beneficial for tremor control as published by Al‐Fatly et al in 2019. The overlap of the respective clinical stimulation setting's VTAs with these fibers explained 62.4% (p < 0.001) of the variance of stimulation‐induced change in intelligibility in a leave‐one‐out analysis.InterpretationThis study demonstrates that SID in essential tremor patients is associated with both motor cortex and cerebellar connectivity. Furthermore, the identified fiber‐based atlas structure might contribute to future postoperative programming strategies to achieve optimal tremor control without speech impairment in essential tremor patients with thalamic DBS. ANN NEUROL 2021;89:315–326
Observation of the Reaction Intermediates of Methanol Dehydrogenation by Cationic Vanadium Clusters
Authors: Hou Gao‐Lei , Faragó Endre , Buzsáki Dániel , Nyulászi László , Höltzl Tibor , Janssens Ewald 
Published: November 2020

AbstractA mass spectrometric study of the reactions of vanadium cationic clusters with methanol in a low‐pressure collision cell is reported. For comparison, the reaction of methanol with cobalt cationic clusters was studied. For vanadium, the main reaction products are fully dehydrogenated species, and partial dehydrogenation and non‐dehydrogenation species are observed as minors, for which the relative intensities increase with cluster size and also at low cluster source temperature cooled by liquid nitrogen; no dehydrogenation products were observed for cobalt clusters. Quantum chemical calculations explored the reaction pathways and revealed that the fully dehydrogenation products of the reaction between Vn+ and methanol are Vn(C)(O)+, in which C and O are separated owing to the high oxophilicity of vanadium. The partial dehydrogenation and non‐dehydrogenation species were verified to be reaction intermediates along the reaction pathway, and their most probable structures were proposed.
Highly Efficient and Selective N‐Formylation of Amines with CO2 and H2 Catalyzed by Porous Organometallic Polymers
Authors: Shen Yajing , Zheng Qingshu , Chen Zhe‐Ning , Wen Daheng , Clark James H. , Xu Xin , Tu Tao 
Published: November 2020

AbstractThe valorization of carbon dioxide (CO2) to fine chemicals is one of the most promising approaches for CO2 capture and utilization. Herein we demonstrated a series of porous organometallic polymers could be employed as highly efficient and recyclable catalysts for this purpose. Synergetic effects of specific surface area, iridium content, and CO2 adsorption capability are crucial to achieve excellent selectivity and yields towards N‐formylation of diverse amines with CO2 and H2 under mild reaction conditions even at 20 ppm catalyst loading. Density functional theory calculations revealed not only a redox‐neutral catalytic pathway but also a new plausible mechanism with the incorporation of the key intermediate formic acid via a proton‐relay process. Remarkably, a record turnover number (TON=1.58×106) was achieved in the synthesis of N,N‐dimethylformamide (DMF), and the solid catalysts can be reused up to 12 runs, highlighting their practical potential in industry.