bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture Treatment Compensated the Altered Functional Connectivity in the Pain Modulation System on Primary Dysmenorrhea: A Pilot Study
Authors: Tu Cheng-Hao , Lee Yu-Chen , Chen Ying-Yu , Chen Chun-Ming , Lu Wen-Chi , Chen Yi-Hung , Yang Su-Tso 
Published: November 2020

Abstract
BackgroundPrimary dysmenorrhea (PDM) is the most commonly encountered gynecological problem in reproductive-age women. We previously reported altered functional connectivity between periaqueductal gray matter and other pain-related brain regions in women with PDM, indicating a maladaptation in the descending pain modulation system. Clinically, acupuncture has been suggested as an effective treatment of PDM. Previous animal studies revealed that acupuncture on specific acupoint can produced analgesic effect via descending pain modulation system. In the present study, we used resting-state functional magnetic resonance imaging to investigate possible changes in descending pain modulation after acupuncture treatment in women with PDM. MethodsThirty-four right-handed adult women with PDM participated in this randomized, single-blinded, sham-controlled study. Each patient was randomly allocated to an 8-week verum or sham acupuncture intervention on the bilateral acupoint Sanyinjiao (SP6). Resting-state functional magnetic resonance imaging was conducted before, during, and after the intervention session to measure the spontaneous activity in brain. The functional connectivity maps between periaqueductal gray matter and other pain-related brain regions were generated to reveal the status of descending pain modulation systems.ResultsAfter 8 weeks, both groups reported decreased menstrual pain. However, the patterns of functional connectivity changes in descending pain modulation system were different after the verum or sham intervention. The effect of the verum acupuncture intervention may be underpinned by compensatory and/or resilience changes in descending pain modulation systems, whereas that of the sham acupuncture intervention may be underpinned by cognitive reappraisal of painConclusionsThe dissimilar pattern of the FC alterations after the verum and sham acupuncture indicating that different brain mechanisms may be responsible for the menstrual pain relief in verum or sham acupuncture intervention. These results may contribute to the discussion of whether acupuncture treatment induces therapeutic physiological alterations or its benefit is attributable to the placebo effect.
How Design Can Impact the Performance of a Healthcare Application, Affect Users’ Decisions and Contribute to Patient’s Well-Being: A Scoping Review Protocol.
Authors: Souza Jose George Dias de , Bublitz Frederico M. , Scherer Daniel 
Published: November 2020

Abstract
Background: Pregnancy is an important phase in a woman's life, the gestational period however is accompanied by fears and apprehension, especially for women who are experiencing this phase for the first time. Prenatal care is essential to prevent diseases and reduce risk for pregnant women, thus enabling healthy development for the baby. Nowadays many women find it difficult to make an adequate prenatal care, for the most varied reasons. Taking into account that the world is increasingly connected to the internet, it is important to understand, analyzing a set of health applications, which are the best decisions from the design point of view, usability to become a useful application for pregnant women, another relevant point is to understand how the architecture of these solutions were designed to be scalable. Thus, a well-defined systematic review is needed to identify the impacts of architectural, design and performance decisions on health applications, reducing risks and minimizing human errors.Methods/Design: This study will follow a well-defined methodological structure. The methodology is separated into the following sections: Research question identification; Extraction of relevant studies; Selection criteria; Charting the data; Collating, summarizing, and reporting the results. The research question aims to analyze the approaches used to build health applications aiming at design decisions, architecture and the impacts that are generated for the end user. The researchers will use the following electronic databases for data extraction: PubMed (Medline); IEEE Xplore Digital Library; ACM Digital Library; Web of Science; and Scopus Document Search. The search for research will consist of a set of terms and keywords.Discussion: This work has the interest of presenting a model, a standard, a guide for creating a health software interface, always aiming at the quality of the interface, the user experience and the possible gain with the performance of the application, considering that users will have more security to make decisions.Systematic review registration: Submitted on October 11, 2020 Open Science Framework.
The Impact of Personal Values and Justifications on Academic Cheating for Business vs. Non-Business Students
Authors: Parks-Leduc Laura , Guay Russell P. , Mulligan Leigh 
Published: November 2020

Abstract
In this study we examine college cheating behaviors of business students compared to non-business students, and investigate possible antecedents to cheating in an effort to better understand why and when students cheat. We specifically examine power values; we find that they are positively related to academic cheating in our sample, and that choice of major (business or non-business) partially mediates the relationship between power values and cheating. We also consider the extent to which students are able to provide justifications for their cheating, and find that business students are more likely to justify (rationalize) their cheating behaviors. Finally, we update the literature in terms of the ways students cheat. We assess newer forms of academic cheating, as increased accessibility to information via the Internet and smartphones may have changed the ways (and ease with which) students cheat – a particularly relevant topic currently, as many classes have moved online during the COVID-19 pandemic. In our study, cheating was especially prevalent when taking quizzes or tests (or completing homework) online. We found that only 10% of participants reported never engaging in any of the cheating behaviors we examined.
Cardiac Arrests after Eating Raw Grass Carp Gall Bladders: A Case Report
Authors: Han Jiayan , Sun Yan , Zhuo Luo , Chen Dongmei , Li Fan , Huang Shouqiu , Chen Xiaobing , Wang Yanli , Luo Jiye , Li Xiaoming 
Published: November 2020

Abstract
BACKGROUND: Cases of poisoning by eating raw fish gallbladder occur mainly in Asia. These cases have been reported mainly with acute liver and kidney damage. We found that the ingestion of carp gallbladder also caused myocardial damage and lead to frequent cardiac arrest in patients with subclinical long QT interval syndrome. Patient concerns: We report a 57-year-old woman with an unexplained Long QT syndrome history who developed arrhythmia sudden death two times following ingestion of raw fish gall bladder.Fish bile poisoning, toxic hepatitis, acute renal failure, cardiac arrest, postoperative cardiopulmonary resuscitation, long QT syndrome were diagnosed. As in this case, myocardial injury caused by fish bile poisoning further leads to cardiac arrest related to LQTS.The patient underwent continued renal replacement therapy (CRRT) and other supportive treatments to manage symptoms, promote detoxing, protect liver and myocardium in our hospital. Then she completed a cardiac pacemaker placement in local hospital.Her liver enzymes profile returned to normal after 18 days, and kidney injury index returned to normal after more than one month. On follow up after three months, her renal as well as the liver parameters were found normal and she never attack malignant arrhythmia again.Conclusion: Eating fish bile can lead to MODS, not merely to liver and kidney damage. Some of the LQTS patients usually have no clinical symptoms. Clinicians should be aware of changes in low-risk LQTS patients when something special happens to them.
WITHDRAWN: Associations of ultrasound-based inflammation patterns with peripheral innate lymphoid cell populations, serum cytokine/chemokines, and treatment response to methotrexate in rheumatoid arthritis and spondyloarthritis
Authors: Kato Manami , Ikeda Kei , Sugiyama Takahiro , Tanaka Shigeru , Iida Kazuma , Suga Kensuke , Nishimura Nozomi , Mimura Norihiro , Kasuya Tadamichi , Kumagai Takashi , Furuya Hiroki , Iwamoto Taro , Iwata Arifumi , Furuta Shunsuke , Suto Akira , Suzuki Kotaro , Kawakami Eiryo , Nakajima Hiroshi 
Published: November 2020

Abstract
Background: We aimed to clarify the associations of musculoskeletal inflammation patterns with peripheral blood innate lymphoid cell (ILC) populations, serum cytokine/chemokines, and treatment response to methotrexate in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).Methods: We enrolled patients with either RA or SpA who had peripheral symptoms and performed comprehensive ultrasound to evaluate power Doppler signals for synovitis (52 joint regions), tenosynovitis (20 tendons), and enthesitis (44 sites). We performed clustering analysis using unsupervised random forest based on the multi-axis ultrasound information and classified the patients into groups. We identified and counted ILC1-3 populations in the peripheral blood by flow cytometry and also measured the serum levels of 20 cytokine/chemokines. We also determined the American College of Rheumatology 20% improvement (ACR20) response at 3 months in 38 patients who initiated treatment with methotrexate after baseline assessment. Results: We enrolled a total of 100 patients with RA (n=66) or SpA (n=34). Synovitis was more prevalent and severer in RA than in SpA, whereas tenosynovitis and enthesitis were comparable between RA and SpA. Patients were classified into two groups which represented synovitis-dominant and synovitis-nondominant inflammation patterns, respectively. While peripheral ILC counts were not significantly different between RA and SpA, they were significantly higher in the synovitis-nondominant group than in the synovitis-dominant group (ILC1-3 p=0.0007, p=0.0061, p=0.0002, respectively). On the other hand, clustering of patients based on serum cytokine/chemokines did not clearly correspond either to clinical diagnoses or to synovitis-dominant/nondominant patterns. The synovitis-nondominant pattern was the factor that predicted no clinical response to methotrexate most significantly (p=0.0065).Conclusions: Ultrasound-detected musculoskeletal inflammation is clustered into synovitis-dominant and nondominant patterns. These patterns are associated with peripheral ILC counts and could predict treatment response to methotrexate. These data suggest that ultrasound-based inflammation patterns can be utilized to establish more individualized treatment for both RA and SpA. Trial registration: The study has been registered in UMIN Clinical Trial Registry (UMIN ID: 000033797, date of registration: 18th of August, 2018).
Effects of magnesium biotinate supplementation on serum insulin, glucose, and lipid parameters along with liver protein levels of intermediary metabolism in rats
Authors: Sahin Kazim , Orhan Cemal , Kucuk Osman , Erten Fusun , Tuzcu Mehmet , Sahin Nurhan , Ojalvo Sara Perez , Komorowski James Richard 
Published: November 2020

Abstract
Background: The objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related genes in rats. Methods: Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet supplemented with either d-biotin at 0.01, 1 or 100 mg/kg BW or magnesium biotinate at 0.01, 1, or 100 mg/kg BW. Results: Serum total cholesterol and triglyceride decreased with biotin by both sources (P < 0.05). Concentrations were lower with magnesium biotinate when comparing the 1 mg/kg dose groups (P < 0.05). Serum, liver, and brain biotin, and liver cyclic guanosine monophosphate (cGMP) concentrations were greater when rats were treated with magnesium biotinate versus d-biotin, particularly when comparing the 1 mg/kg and 100 mg/kg dose groups (P < 0.05). Both forms of biotin decreased the liver SREBP‐1c and FAS and increased AMPK-α1, ACC-1, ACC-2, PCC, and MCC levels (P < 0.05). The magnitudes of responses were more emphasized with magnesium biotinate. Conclusions: Magnesium biotinate, compared with a commercial d-biotin, is more effective in reducing serum lipid concentrations and in regulating gene levels of intermediary metabolism-related biomarkers.
Public Trust in Healthcare System and Its Correlates during the COVID-19 Epidemic in Iran
Authors: Vardanjani Hossein Molavi , Imanieh Mohammad-Hadi , Hassani Amir-Hossein , Bagheri-Lankarani Kamran 
Published: November 2020

Abstract
Background: Public trust in the healthcare system is a critical necessity of management in public health crises such as the COVID-19 pandemic. To rapidly assess the public trust in the healthcare system during the COVID-19 epidemic and its correlates in Iran.Methods: A cross-sectional rapid assessment was conducted in Iran during the COVID-19 epidemic in the country. A probability proportional to size multistage random sampling was applied. Sampling was done in 15 provinces. We collected data on public perceived fear, public trust in health system and socio-demographics. Ordinary least square regression modeling was applied to identify correlates of public trust.Results: A total of 5250 adults (response rate: 76%) were participated in the study. Mean of reported trust scores was 50.3±22.8, and of fear scores was 72.0±17.8. Being male (p=0.006), higher levels of education (p<0.001) and socio-economic status (p<0.001), and higher fear scores (p<0.001) were independently correlated with trust in healthcare system. Conclusion: At the time of the COVID-19 epidemic in Iran, public trust in healthcare system is low. A dynamic public epidemic communication with appropriate strategies to communicate with higher social classes is urgent in Iran. Rapid assessments to identify appropriate strategies are needed. These results might be generalizable to the other similar countries during the COVID-19 pandemic.
Analysis of IgM, IgA, and IgG Isotype Antibodies Directed Against SARS‑CoV‑2 Spike Glycoprotein and ORF8 in the Course of COVID‑19.
Authors: Meinberger Denise , Koch Manuel , Roth Annika , Hermes Gabriele , Stemler Jannik , Cornely Oliver A. , Streichert Thomas , Klatt Andreas R. 
Published: November 2020

Abstract
Immunoassays are a standard diagnostic tool assessing immunity in severe acute respiratory syndrome coronavirus type 2 (SARS‑CoV‑2) infection. However, immunoassays do not provide information about contaminating antigens or cross‑reaction and might exhibit inaccurate high sensitivity and low specificity. We aimed to gain insight into the serological immune response of SARS‑CoV‑2 patients by immunoblot analysis. We analyzed serum immunoglobulins IgM, ‑A, and ‑G directed against SARS‑CoV‑2 proteins by immunoblot analysis from 12 infected patients. We determined IgG isotype antibodies by commercially available ELISA, and assessed clinical parameters of inflammation status, kidney, and liver injury. We found evidence for antibody cross‑reactivity, which calls into question a reliable assessment of serum samples tested negative for anti‑SARS‑CoV‑2 antibodies by immunoassays. Nevertheless, for the detection of IgG anti‑SARS‑CoV‑2 antibodies, our data suggest that the use of the spike glycoprotein in immunoassays should be sufficient to identify positive patients. Using a combination of the spike glycoprotein and the open reading frame 8 protein could prove to be the best for the detection of patients positive for anti‑SARS‑CoV‑2 IgM antibodies. We found that the antibody response alone is not decisive for the course of the disease but the inflammation parameters are promising indicators.
Management of chlamydia and gonorrhoea infections diagnosed in primary care using a centralised nurse-led telephone-based service: mixed methods evaluation
Authors: Horwood Jeremy , Brangan Emer , Manley Petra , Horner Paddy , Muir Peter , North Paul , MacLeod John 
Published: November 2020

Abstract
Background: Up to 18% of genital Chlamydia infections and 9% of Gonorrhoea infections in England are diagnosed in Primary Care. Evidence suggests that a substantial proportion of these cases are not managed appropriately in line with national guidelines. With the increase in sexually transmitted infections and the emergence of antimicrobial resistance, their timely and appropriate treatment is a priority. We investigated feasibility and acceptability of extending the National Chlamydia Screening Programme’s centralised, nurse-led, telephone management (NLTM) as an option for management of all cases of chlamydia and gonorrhoea diagnosed in Primary Care. Methods: Randomised feasibility trial in 11 practices in Bristol with nested qualitative study. In intervention practices patients and health care providers (HCPs) had the option of choosing NLTM or usual care for all patients tested for Chlamydia and Gonorrhoea. In control practices patients received usual care.Results: 1154 Chlamydia/gonorrhoea tests took place during the 6-month study, with a chlamydia positivity rate of 2.6% and gonorrhoea positivity rate of 0.8%. The NLTM managed 335 patients. Interviews were conducted with sixteen HCPs (11 GPs, 5 nurses) and 12 patients (8 female). HCPs were positive about the NLTM, welcomed the partner notification service, though requested more timely feedback on the management of their patients. Explaining the NLTM to patients didn’t negatively impact on consultations. Patients found the NLTM acceptable, more convenient and provided greater anonymity than usual care. Patients appreciated getting a text message regarding a negative result and valued talking to a sexual health specialist about positive results.Conclusion: Extension of this established NLTM intervention to a greater proportion of patients was both feasible and acceptable to both patients and HCP, could provide a better service for patients, whilst decreasing primacy care workload. The study provides evidence to support the wider implementation of this NLTM approach to managing chlamydia and gonorrhoea diagnosed in primary care.
Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
Authors: Mutoji Kazadi Nadine , Sun Mingxia , Nash Amanda , Puri Sudan , Hascall Vincent , Coulson-Thomas Vivien J 
Published: November 2020

Abstract
Background: Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-established anti-inflammatory molecule, is present within the glial scar. In the present study we investigated the role of TSG-6 within the glial scar. Methods: TSG-6 null and littermate control mice were subjected to penetrating brain injuries (2 mm puncture wound to the frontal cortex), after which both the injury site and remaining injured hemisphere were analyzed. The presence of activated astrocytes, inflammatory markers and glial scar components was evaluated by real-time PCR and immunofluorescence. Results: Our findings show that mice lacking TSG-6 present a more severe inflammatory response after injury, which was correlated with an enlarged area of astrogliosis beyond the injury site. Conclusion: Our data provides evidence that TSG-6 has an anti-inflammatory role within the glial scar.
Prevalence and associated factors of undernutrition among pregnant women visiting ANC clinics in Silte zone, southern Ethiopia
Authors: Muze Mohammed , Yesse Mubarek , Kedir Shemsu , Mustefa Abdilmejid 
Published: November 2020

Abstract
Background: Maternal undernutrition is highly prevalent in underdeveloped countries. Hence, this study was intended to determine the prevalence and associated factors of undernutrition among pregnant women visiting ANC clinics in Silte Zone..Method: Facility-based cross-sectional study was conducted from July to January 2019. Systematic random sampling technique was used to select 422 study participants from 11 randomly selected health facilities. Data was collected by using a structured-interviewer administered questionnaire. Mid upper arm circumference (MUAC) was measured by standard non stretchable MUAC tape. Data was entered into a computer using Epi data 3.1 and edited, cleaned, and analyzed using SPSS version 20. Both bivariate and multiple logistic regression analyses were employed to identify factors associated with maternal undernutrition.Result: In this study, the overall prevalence of undernutrition among study subjects was 21.8%. Age greater than 31 years of women (AOR=0.15; 95% CI: 0.03, 0.93), Birth intervals > 2 years (AOR= 0.18; 95% CI: 0.04, 0.76), good nutritional knowledge (AOR=0.34; 95% CI: 0.17, 0.67), and having no dietary change as a result of current pregnancy AOR=6.02; 95% CI: 2.99, 12.14) were significantly associated with undernutrition.Conclusions: The prevalence of undernutrition among pregnant women was 21.8 %. Current estimate is lower than previously reported in the study area but higher than reported in developed country. Age of women, Birth intervals, and Dietary change as a result of current pregnancy and Nutrition knowledge were important risk factors/ predictors of undernutrition (MUAC < 23 cm). Interventions targeting maternal nutrition education and child spacing with giving special emphasis to adolescent pregnant women are recommended.