bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Features of the Enhancements in Electron Density at Low Latitudes
Authors: Liu Libo , Ding Zonghua , Le Huijun , Chen Yiding , Zhang Hui , Wu Jian , Li Guozhu , Wan Weixing 
Published: February 2020

AbstractIn this study, we present some new features of the enhancements of electron density in the ionospheric F region at low latitudes. The peak parameters of the ionosphere were recorded by Sanya (109.6°E, 18.3°N) ionosonde and electron density profiles analyzed were measured by the Qujing (103.8°E, 25.6°N) incoherent scatter radar. The peak electron density of the F2 layer (NmF2) is found to be enhanced in the afternoon and sunset hours. Common features in the cases demonstrate that the NmF2 increases at low latitudes are characterized by a descent of the peak height (hmF2). Meanwhile, the electron density at Qujing shows an increase at the bottom of the ionosphere and a depression at topside altitudes. It is consistent with those of the ionosonde measurements at Sanya, for both the daytime and nighttime enhancements. Cross correlation analyses reveal a lag of NmF2 to hmF2 in the cases. After taking time shifts some events of the enhancements in NmF2 are still associated with a downwelling hmF2, confirming the processes which drive a lower hmF2 and a convergence of plasma flux may possibly bring about a rise in NmF2.
Structural Controls on Rupture Extent of Recent Sumatran Fault Zone Earthquakes, Indonesia
Authors: Salman Rino , Lindsey Eric O. , Feng Lujia , Bradley Kyle , Wei Shengji , Wang Teng , Daryono Mudrik R. , Hill Emma M. 
Published: February 2020

AbstractWe present geodetically derived coseismic slip models for four Mw~6 strike‐slip earthquakes that struck the mainland island of Sumatra, Indonesia, between 2007 and 2016. Three of these earthquakes ruptured segments of the Sumatran Fault Zone: the 2007 Mw6.3 and 6.4 Lake Singkarak doublet, and the 2009 Mw6.6 Dikit event. The fourth earthquake, the 2016 Mw6.6 Pidie Jaya event, ruptured an unmapped active fault in a region of historically low seismicity near the northern coast of Aceh. Our results suggest that (1) the estimated rupture extents of the 2007 Lake Singkarak doublet and 2009 Dikit event were limited by geological structures such as step overs that define segment boundaries, (2) the 2016 Pidie Jaya event did not produce surface rupture despite the fact that it produced large shallow slip of more than 2.5 m, and (3) the remaining seismic gaps on the Sumatran Fault Zone are primarily located between the equator and northern Sumatra. We strongly recommend that seismic hazard assessment for densely populated areas in Sumatra include threats not only from the Sumatran Fault Zone but also from additional potentially active faults outside of the main Sumatran Fault Zone.
Are the Stress Drops of Small Earthquakes Good Predictors of the Stress Drops of Moderate‐to‐Large Earthquakes?
Authors: Hardebeck Jeanne L. 
Published: February 2020

AbstractThe stress drops of small earthquakes often exhibit spatial patterns of variability. If moderate and large earthquakes follow the same spatial patterns, the stress drops of possible future damaging earthquakes could be better predicted by considering the stress drops of nearby small events. Better stress drop predictability could reduce ground‐motion uncertainty in probabilistic seismic hazard assessment and earthquake early warning. I find that for an internally consistent stress drop catalog ofM1.8–3.1 events in Southern California, the stress drops of the bigger earthquakes are predictable from the nearby smaller events. However, this catalog only weakly spatially correlates with another catalog ofM3.0–5.8 earthquakes and is spatially uncorrelated with five other stress drop catalogs ofM≥ 3.4 earthquakes. For Southern California eventsM5.5–7.5, stress drops compiled from the literature are weakly spatially correlated with the stress drops of theM1.8–3.1 events, although the correlations are not statistically significant. The lack of strong spatial correlation may be due to actual differences in the controlling factors of stress drop, for example, dynamic weakening in moderate‐to‐large earthquakes. Alternatively, a stronger spatial correlation may exist that is obscured by methodological heterogeneity and large errors in the stress drop estimates. Either way, the stress drops of small earthquakes do not appear to be good predictors of the stress drops of nearby moderate‐to‐large earthquakes, at least for current techniques of stress drop estimation. If these results are representative, small‐earthquake stress drops are not currently useful for substantially reducing uncertainty in probabilistic seismic hazard assessment and earthquake early warning.
Large‐Scale Geographical Variations and Climatic Controls on Crown Architecture Traits
Authors: Su Yanjun , Hu Tianyu , Wang Yongcai , Li Yumei , Dai Jingyu , Liu Hongyan , Jin Shichao , Ma Qin , Wu Jin , Liu Lingli , Fang Jingyun , Guo Qinghua 
Published: February 2020

AbstractCrown architecture is a critical component for a tree to interact with the ambient environment and to compete with neighbors. However, little is known regarding how climate variability may shape crown architecture traits across large geographical extents and whether crown architecture traits have coordinated variations with trunk and leaf traits to climate gradients. Here we used Quercus mongolica trees as an example, used the cutting‐edge terrestrial laser scanning technique to accurately characterize their crown architecture traits, and explored their variabilities along with environmental variability across large climate gradients in northern China. Our results showed that there are significant spatial variations in trunk, crown, and leaf traits even for the same genetic group across large environmental gradients. Tree height and leaf size had tight covariations with precipitation (|R|> 0.8, p < 0.01). We also observed coordinated variations among crown architecture traits related to canopy shape (e.g., primary branch insertion angle, chord length ratio), trunk traits (e.g., tree height), leaf traits (e.g., specific leaf area), and climate variability, highlighting there are likely fundamental evolutionary strategies regulating these covariations. With a projected drier and hotter climate scenario in this region, our results further suggest trees are expected to transit from a “tree shape” to a “shrub shape,” with large ecological and ecophysiological impacts on this region.
Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype
Authors: Sarn Nicholas , Jaini Ritika , Thacker Stetson , Lee Hyunpil , Dutta Ranjan , Eng Charis 
Published: February 2020

AbstractGermline mutations in PTEN account for ~10% of cases of autism spectrum disorder (ASD) with coincident macrocephaly. To explore the importance of nuclear PTEN in the development of ASD and macrocephaly, we previously generated a mouse model with predominantly cytoplasmic localization of Pten (Ptenm3m4/m3m4).Cytoplasmic predominant Pten localization results in a phenotype of extreme macrocephaly and autistic-like traits. Transcriptomic analysis of the Ptenm3m4/m3m4 cortex found upregulated gene pathways related to myeloid cell activation, myeloid cell migration, and phagocytosis. These transcriptomic findings were used to direct in vitro assays on Pten wild-type and Ptenm3m4/m3m4 microglia. We found increased Iba1 and C1q expression with enhanced phagocytic capacity in Ptenm3m4/m3m4 microglia, indicating microglial activation. Moreover, through a series of neuron-microglia co-culture experiments, we found Ptenm3m4/m3m4 microglia are more efficient at synaptic pruning compared with wild-type controls. In addition, we found evidence for neuron-microglia cross-talk, where Ptenm3m4/m3m4 neurons elicit enhanced pruning from innately activated microglia. Subsequent in vivo studies validated our in vitro findings. We observed a concurrent decline in the expression of Pten and synaptic markers in the Ptenm3m4/m3m4 cortex. At ~3 weeks of age, with a 50% drop in Pten expression compared with wild-type levels, we observed enhanced activation of microglia in the Ptenm3m4/m3m4 brain. Collectively, our data provide evidence that dysregulated Pten in microglia has an etiological role in microglial activation, phagocytosis, and synaptic pruning, creating avenues for future studies on the importance of PTEN in maintaining microglia homeostasis.
Detection of pancreatic ductal adenocarcinoma with galectin-9 serum levels
Authors: Seifert Adrian M. , Reiche Charlotte , Heiduk Max , Tannert Anna , Meinecke Ann-Christin , Baier Stephanie , von Renesse Janusz , Kahlert Christoph , Distler Marius , Welsch Thilo , Reissfelder Christoph , Aust Daniela E. , Miller George , Weitz Jürgen , Seifert Lena 
Published: February 2020

AbstractPancreatic ductal adenocarcinoma (PDAC) responds poorly to checkpoint blockade, such as anti-CTLA-4 and anti-PD-1. Galectin-9, a β-galactoside-binding lectin, promotes immune suppression through T-cell inhibition, and programming of tolerogenic macrophages. Of all cancers tested, PDAC showed the highest expression of LGALS9 (galectin-9) mRNA. We analyzed formalin-fixed and paraffin-embedded specimens from 83 patients with PDAC stained for galectin-9. Using flow cytometry, we determined galectin-9 expression on immune cells from tumor and matched blood samples from 12 patients with resectable PDAC. Furthermore, we analyzed galectin-9 serum levels by enzyme-linked immunosorbent assay using serum samples from 70 patients with PDAC, from 36 individuals with benign pancreatic disease, and from 28 healthy controls. Galectin-9 was highly expressed in human PDAC compared with normal pancreas and present on both tumor and immune cells. Tumor-infiltrating immune cells, especially CD3+ T cells, showed upregulation of galectin-9 compared with immune cells from matched blood. Blood γδ T cells from PDAC patients had higher galectin-9 expression than γδ T cells from healthy individuals. Galectin-9 polarized macrophages toward a protumoral M2 phenotype leading to suppressed T-cell cytokine secretion. Furthermore, serum concentration of galectin-9 was able to discriminate PDAC from benign pancreatic disease and healthy individuals, and was prognostic for stage IV patients. Galectin-9 is a new biomarker for the detection of PDAC.
Dysregulation of the miR-148a–GLUT1 axis promotes the progression and chemoresistance of human intrahepatic cholangiocarcinoma
Authors: Tiemin Pei , Peng Xiao , Qingfu lang , Yan Wang , Junlin Xue , Zhefeng He , Ming Zhao , Desen Liang , Qinghui Meng 
Published: February 2020

AbstractIntrahepatic cholangiocarcinoma (iCCA) is a highly fatal malignant cancer worldwide. Elucidating the underlying molecular mechanism of iCCA progression is critical for the identification of new therapeutic targets. The present study explored the role of the miR-148a–GLUT1 axis in the progression of iCCA. The expression of GLUT1 was detected by using immunohistochemistry, western blot assays, and real-time polymerase chain reaction. The effects of GLUT1 on cell proliferation, invasion, and chemoresistance were investigated both in vitro and in vivo. A luciferase reporter assay was used to explore the effect of miR-148a on GLUT1 expression. GLUT1 was overexpressed in iCCA tissues. GLUT1 overexpression was associated with shorter overall and disease-free survival. Knockdown of GLUT1 reduced, while overexpression of GLUT1 promoted, the proliferation, motility, and invasiveness of iCCA cells in vitro and in vivo. Silencing GLUT1 significantly sensitized iCCA cells to gemcitabine in vitro and in vivo. GLUT1 was directly regulated by miR-148a, whose downregulation was associated with the proliferation, migration, and invasion of iCCA cells. WZB117, a GLUT1 inhibitor, inhibited tumor growth in an iCCA patient-derived xenograft model. These results indicate that downregulation of miR-148a levels results in GLUT1 overexpression in iCCA, leading to iCCA progression and gemcitabine resistance.
Comparative genomics: Dominant coral-bacterium Endozoicomonas acroporae metabolizes dimethylsulfoniopropionate (DMSP)
Authors: Tandon Kshitij , Lu Chih-Ying , Chiang Pei-Wen , Wada Naohisa , Yang Shan-Hua , Chan Ya-Fan , Chen Ping-Yun , Chang Hsiao-Yu , Chiou Yu-Jing , Chou Ming-Shean , Chen Wen-Ming , Tang Sen-Lin 
Published: February 2020

Abstract
Dominant coral-associated Endozoicomonas bacteria species are hypothesized to play a role in the coral sulfur cycle by metabolizing dimethylsulfoniopropionate (DMSP) into dimethylsulfide (DMS); however, no sequenced genome to date harbors genes for this process. In this study, we assembled high-quality (&gt;95% complete) draft genomes of strains of the recently added species Endozoicomonas acroporae (Acr-14T, Acr-1, and Acr-5) isolated from the coral Acropora sp. and performed a comparative genomic analysis on the genus Endozoicomonas. We identified DMSP CoA-transferase/lyase—a dddD gene homolog in all sequenced genomes of E. acroporae strains—and functionally characterized bacteria capable of metabolizing DMSP into DMS via the DddD cleavage pathway using RT-qPCR and gas chromatography (GC). Furthermore, we demonstrated that E. acroporae strains can use DMSP as a carbon source and have genes arranged in an operon-like manner to link DMSP metabolism to the central carbon cycle. This study confirms the role of Endozoicomonas in the coral sulfur cycle.
Long-living and highly efficient bio-hybrid light-emitting diodes with zero-thermal-quenching biophosphors
Authors: Espasa Anna , Lang Martina , Aguiño Carmen F. , Sanchez-deAlcazar Daniel , Fernández-Blázquez Juan P. , Sonnewald Uwe , Cortajarena Aitziber L. , Coto Pedro B. , Costa Rubén D. 
Published: February 2020

AbstractBio-hybrid light-emitting diodes (Bio-HLEDs) based on color down-converting filters with fluorescent proteins (FPs) have achieved moderate efficiencies (50 lm/W) and stabilities (300 h) due to both thermal- and photo-degradation. Here, we present a significant enhancement in efficiency (~130 lm/W) and stability (>150 days) using a zero-thermal-quenching bio-phosphor design. This is achieved shielding the FP surface with a hydrophilic polymer allowing their homogenous integration into the network of a light-guiding and hydrophobic host polymer. We rationalize how the control of the mechanical and optical features of this bio-phosphor is paramount towards highly stable and efficient Bio-HLEDs, regardless of the operation conditions. This is validated by the relationships between the stiffness of the FP-polymer phosphor and the maximum temperature reached under device operation as well as the transmittance of the filters and device efficiency.
A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England
Authors: Chalitsios Christos V. , Shaw Dominick E. , McKeever Tricia M. 
Published: February 2020

AbstractExposure to oral corticosteroids (OCS) is associated with an increased risk of osteoporosis and fragility fractures. Guidelines suggest bisphosphonate (BP) therapy as the first-line treatment of glucocorticoid-induced osteoporosis (GIOP). This population study used publicly available data, including prescription annual cost analysis and monthly practice-level data. Our aim was to examine the prescribing of OCS and BP at practice level and investigate reasons for variation using a mixed-effect negative binomial regression analysis. There was a rise in OCS and BP prescriptions of 55% and 1200% from 1998 to 2018, respectively. Of the 6586 included practices, the median (IQR) of OCS and BP prescriptions were 120.8 (84.8–160.4) and 107.7 (73.8–147.4) per 1000 patients, respectively. Asthma and chronic obstructive pulmonary disease (COPD) were significantly associated with OCS use (p < 0.0001), but only COPD was associated with BP use (p < 0.0001). Higher OCS prescribing rates were associated with higher BP prescribing rates (5th to 1st quintile—IRR = 1.99; 95% CI: 1.88–2.10). Practice list size, deprivation and advanced age were all associated with both drugs (p < 0.0001). In conclusion, although OCS use is positively associated with BP prescription, variation among practices and CCGs exists. The variation in prescribing suggests there is still a need to improve GIOP prevention.
Quantum coherence and state conversion: theory and experiment
Authors: Wu Kang-Da , Theurer Thomas , Xiang Guo-Yong , Li Chuan-Feng , Guo Guang-Can , Plenio Martin B. , Streltsov Alexander 
Published: February 2020

AbstractThe resource theory of coherence studies the operational value of superpositions in quantum technologies. A key question in this theory concerns the efficiency of manipulation and interconversion of the resource. Here, we solve this question completely for qubit states by determining the optimal probabilities for mixed-state conversions via stochastic incoherent operations. Extending the discussion to distributed scenarios, we introduce and address the task of assisted incoherent state conversion, where the process is enhanced by making use of correlations with a second party. Building on these results, we demonstrate experimentally that the optimal state-conversion probabilities can be achieved in a linear optics setup. This paves the way towards real world applications of coherence transformations in current quantum technologies.
Combined lithotripsy of mechanical clamping and electrohydraulics in facilitating endoscopic management of refractory residual biliary calculi after surgery
Authors: Wen Xu-dong , Ren Li-na , Wang Tao , Wang Xiao-juan , Navarro-Alvarez Nalu , Li Liang-ping , Liu Wei-hui 
Published: February 2020

AbstractAlthough postoperative cholangioscopy (POC) guided electrohydraulic lithotripsy (EHL) is considered to be a conventional technique for residual biliary calculi, its efficacy still needs to be improved to fit in the managemet of refractory calculi. This study evaluated the efficacy and safety of combined lithotripsy of mechanical clamping and electrohydraulics in fragmentation and removal of refractory calculi. Totally, 281 patients, who suffered from residual biliary calculi after hepatectomy and underwnet POC from August 2016 to June 2018 were involved. The first 128 patients were subjected to conventional EHL, and later consective 153 to combined lithotripsyof mechanical clamping and EHL. Perioperative data, technical information, treatment outcomes and follow-up results were collected. Clinical characteristics were statistically comparable (P > 0.05). The overall POC interventional sessions (2.0 ± 0.65 vs. 2.9 ± 1.21 sessions), average operating time (99.1 ± 34.88 vs. 128.6 ± 72.87 minutes), incidence of intraoperative hemobilia (4.58% vs. 10.93%), cholangitis (6.54% vs. 14.06%), postoperative complications (10.45% vs. 21.87%), T-tube retaining time after first POC (20.7 ± 5.35 vs. 28.1 ± 8.28 days), and treatment costs ($2375 ± 661.72 vs. $3456.7 ± 638.07) were significantly lower in the combined lithotripsy group than those in the EHL group (P < 0.05). There were no differences between the two groups in calculi recurrence at half-a year, or one year follow-up. In conclusion, combined lithotripsy of mechanical clamping and electrohydraulics can safely and effectively benefit postoperative patients along with refractory residual biliary calculi.
Composite diagnostic criteria are problematic for linking potentially distinct populations: the case of frailty
Authors: Chao Yi-Sheng , Wu Chao-Jung , Wu Hsing-Chien , Hsu Hui-Ting , Tsao Lien-Cheng , Cheng Yen-Po , Lai Yi-Chun , Chen Wei-Chih 
Published: February 2020

AbstractComposite diagnostic criteria are common in frailty research. We worry distinct populations may be linked to each other due to complicated criteria. We aim to investigate whether distinct populations might be considered similar based on frailty diagnostic criteria. The Functional Domains Model for frailty diagnosis included four domains: physical, nutritive, cognitive and sensory functioning. Health and Retirement Study participants with two or more deficiencies in the domains were diagnosed frail. The survival distributions were analyzed using discrete-time survival analysis. The distributions of the demographic characteristics and survival across the groups diagnosed with frailty were significantly different (p < 0.05). A deficiency in cognitive functioning was associated with the worst survival pattern compared with a deficiency in the other domains (adjusted p < 0.05). The associations of the domains with mortality were cumulative without interactions. Cognitive functioning had the largest effect size for mortality prediction (Odds ratios, OR = 2.37), larger than that of frailty status (OR = 1.92). The frailty diagnostic criteria may take distinct populations as equal and potentially assign irrelevant interventions to individuals without corresponding conditions. We think it necessary to review the adequacy of composite diagnostic criteria in frailty diagnosis.
SLIM: Simultaneous Logic-in-Memory Computing Exploiting Bilayer Analog OxRAM Devices
Authors: Kingra Sandeep Kaur , Parmar Vivek , Chang Che-Chia , Hudec Boris , Hou Tuo-Hung , Suri Manan 
Published: February 2020

Abstractvon Neumann architecture based computers isolate computation and storage (i.e. data is shuttled between computation blocks (processor) and memory blocks). The to-and-fro movement of data leads to a fundamental limitation of modern computers, known as the Memory wall. Logic in-Memory (LIM)/In-Memory Computing (IMC) approaches aim to address this bottleneck by directly computing inside memory units thereby eliminating energy-intensive and time-consuming data movement. Several recent works in literature, propose realization of logic function(s) directly using arrays of emerging resistive memory devices (example- memristors, RRAM/ReRAM, PCM, CBRAM, OxRAM, STT-MRAM etc.), rather than using conventional transistors for computing. The logic/embedded-side of digital systems (like processors, micro-controllers) can greatly benefit from such LIM realizations. However, the pure storage-side of digital systems (example SSDs, enterprise storage etc.) will not benefit much from such LIM approaches as when memory arrays are used for logic they lose their core functionality of storage. Thus, there is the need for an approach complementary to existing LIM techniques, that’s more beneficial for the storage-side of digital systems; one that gives compute capability to memory arrays not at the cost of their existing stored states. Fundamentally, this would require memory nanodevice arrays that are capable of storing and computing simultaneously. In this paper, we propose a novel ‘Simultaneous Logic in-Memory’ (SLIM) methodology which is complementary to existing LIM approaches in literature. Through extensive experiments we demonstrate novel SLIM bitcells (1T-1R/2T-1R) comprising non-filamentary bilayer analog OxRAM devices with NMOS transistors. Proposed bitcells are capable of implementing both Memory and Logic operations simultaneously. Detailed programming scheme, array level implementation, and controller architecture are also proposed. Furthermore, to study the impact of proposed SLIM approach for real-world implementations, we performed analysis for two applications: (i) Sobel Edge Detection, and (ii) Binary Neural Network- Multi layer Perceptron (BNN-MLP). By performing all computations in SLIM bitcell array, huge Energy Delay Product (EDP) savings of ≈75× for 1T-1R (≈40× for 2T-1R) SLIM bitcell were observed for edge-detection application while EDP savings of ≈3.5× for 1T-1R (≈1.6× for 2T-1R) SLIM bitcell were observed for BNN-MLP application respectively, in comparison to conventional computing. EDP savings owing to reduction in data transfer between CPU ↔ memory is observed to be ≈780× (for both SLIM bitcells).