bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using a pharmacogenetic clinical decision support system to improve psychopharmacotherapy dosing in patients with affective disorders
Authors: Zastrozhin Michael , Skryabin Valentin , Sorokin Alexander , Buzik Oleg , Bedina Inessa , Grishina Elena , Ryzhikova Kristina , Shipitsyn Valery , Bryun Evgeny , Sychev Dmitry 
Published: September 2020

Abstract

Objectives
Although pharmacogenetic tests provide the information on a genotype and the predicted phenotype, these tests do not themselves provide the interpretation of data for a physician. Currently, there are approximately two dozen pharmacogenomic clinical decision support systems (CDSSs) used in psychiatry. Implementation of the CDSSs forming the recommendations on drug and dose selection according to the results of pharmacogenetic testing is an urgent task. Fulfillment of this task will allow increasing the efficacy of therapy and decreasing the risk of undesirable side effects.

Methods
The study included 118 male patients (48 in the main group and 70 in the control group) with affective disorders and comorbid alcohol use disorder. To evaluate the efficacy and safety of therapy, several international psychometric scales and rating scales to measure side effects were used. Genotyping was performed using the real-time polymerase chain reaction with allele-specific hybridization. Pharmacogenetic testing results were interpreted using free software PGX2 (LLE Medicine, Russian Federation, Biomedical Cluster of Skolkovo, Moscow Innovative Cluster; www.pgx2.com).

Results
The statistically significant differences across the scores on psychometric scales were revealed. For instance, the total score on the Hamilton Rating Scale for Depression by day 9 was 9.0 [8.0; 10.0] for the main group and 11.0 [10.0; 12.0] (p<0.001) for the control group and by day 16 it was 4.0 [2.0; 6.0] for the main group and 14.0 [13.0; 14.0] (p<0.001) for the control group. The UKU Side-Effect Rating Scale (UKU) also revealed a statistically significant difference. The total score on the UKU scale by day 9 was 4.0 [4.0; 5.0] for the main group and 5.0 [5.0; 6.0] (p<0.001) for the control group and by day 16 this difference grew significantly: 3.0 [0.0; 4.2] for the main group and 9.0 [7.0; 11.0] (p<0.001) for the control group.

Conclusions
Pharmacogenetic-guided personalization of the drug dose in patients with affective disorders and comorbid alcohol use disorder can reduce the risk of undesirable side effects and pharmacoresistance. It allows recommending the use of pharmacogenetic CDSSs for optimizing drug dosage.
Methyl jasmonate delays the latency to anoxic convulsions by normalizing the brain levels of oxidative stress biomarkers and serum corticosterone contents in mice with repeated anoxic stress
Authors: Adelaja Abayomi Ololade , Oluwole Oluwafemi Gabriel , Aluko Oritoke Modupe. , Umukoro Solomon 
Published: September 2020

Abstract

Objectives
Repeated exposure to anoxic stress damages the brain through cortisol-mediated increases in oxidative stress and cellular-antioxidants depletion. Thus, compounds with antioxidant property might confer protection against anoxic stress-induced brain injuries. In this study, we further examined the protective effect of methyl jasmonate (MJ), a potent anti-stress agent against anoxic stress-induced convulsions in mice.

Methods
Thirty-six male Swiss mice randomized into six groups (n=6) were given MJ (25, 50 and 100 mg/kg, i.p.) or vehicle (10 mL/kg, i.p.) 30 min before 15 min daily exposure to anoxic stress for 7 days. The latency(s) to anoxic convulsion was recorded on day 7. The blood glucose and serum corticosterone levels were measured afterwards. The brains were also processed for the determination of malondialdehyde, nitrite, and glutathione levels.

Results
Methyl jasmonate (MJ) delayed the latency to anoxic convulsion and reduced the blood glucose and serum corticosterone levels. The increased malondialdehyde and nitrite contents accompanied by decreased glutathione concentrations in mice with anoxic stress were significantly attenuated by MJ.

Conclusions
These findings further showed that MJ possesses anti-stress property via mechanisms relating to the reduction of serum contents of corticosterone and normalization of brain biomarker levels of oxidative stress in mice with anoxic stress.
Instanton bundles on two Fano threefolds of index 1
Authors: Casnati Gianfranco , Genc Ozhan 
Published: September 2020

Abstract
We deal with instanton bundles on the product

ℙ
1

×

ℙ
2

{\mathbb{P}^{1}\times\mathbb{P}^{2}}

and the blow up of

ℙ
3

{\mathbb{P}^{3}}

along a line.
We give an explicit construction leading to instanton bundles.
Moreover, we also show that they correspond to smooth points of a unique irreducible component of their moduli space.
Smart DRA for beam width and orientation control
Authors: Yaduvanshi Rajveer S. , Gupta Richa , Katiyar Saurabh 
Published: September 2020

Abstract
Smartdielectric resonator antenna (DRA) having beam control mechanism is anew area to be explored by antenna researchers. Proposed new geometry DRA has low loss, design flexibility, high efficiency, compact size and desired radiated beam control. Developing beam control in new geometry DRAs is investigated for the first time in this letter. Unique technique for beam control and beam width control is proposed using pit top and mount top DRA. Gain is controlled from 5.0 to 9.98 dBi and beam is controlled from ±30° to ±70° in broadside radiation pattern. U shape pit DRA has maximum directive gain of 9.98 dBi and efficiency 98% at 5.8 GHz frequency. Measured and simulated results of radiation pattern and reflection coefficient are found to be in close proximity. Hardware of U shape pit top DRA, mount top DRA, left side arc top DRA, right side arc shape top DRA is developed and investigated. Mobile and cellular communication network need wide coverage, hence large beam width is required. Narrowing of beam width at higher order mode is also achieved.
Phage-display reveals interaction of lipocalin allergen Can f 1 with a peptide resembling the antigen binding region of a human γδT-cell receptor
Authors: Habeler Matthias , Redl Bernhard 
Published: September 2020

Abstract
Although some progress has been achieved in understanding certain aspects of the allergenic mechanism of animal lipocalins, they still remain largely enigmatic. One possibility to unravel this property is to investigate their interaction with components of the immune system. Since these components are highly complex we intended to use a high-throughput technology for this purpose. Therefore, we used phage-display of a random peptide library for panning against the dog allergen Can f 1. By this method we identified a Can f 1 binding peptide corresponding to the antigen-binding site of a putative γδT-cell receptor. Additional biochemical investigations confirmed this interaction.
Establishing content for a digital educational support group for new adolescent mothers in the Dominican Republic: a user-centered design approach
Authors: Stonbraker Samantha , Haight Elizabeth , Soriano Leidy , Guijosa Linda , Davison Eliza , Bushley Diane , Messina Luz , Halpern Mina 
Published: September 2020

Abstract

Background
As digital interventions to improve health become widespread globally, it is critical to include target end-users in their design. This can help ensure interventions are maximally beneficial among intended populations.

Objectives
To generate the content of a digital educational support group, administered through WhatsApp, for new adolescent mothers and establish participants’ cellular access and WhatsApp use.

Participants
Adolescent mothers with new babies.

Methods
We completed a two-phase user-centered design process. In phase I design sessions, participants discussed their postpartum experiences and completed an activity to elucidate their health and wellbeing information needs. In phase II sessions, participants individually identified which health information topics were important to them, then all topics were prioritized as a group. Phase II participants also completed a brief survey on cell phone access and WhatsApp use.

Results
Phase I included 24 participants, 21 of whom completed phase II. Priority health and wellbeing information topics in the postpartum period were identified as: child growth and development, understanding your baby, common childhood illnesses, breastfeeding, childhood nutrition, family planning, and self-care. Of phase II participants, 45% had cellular phone access and none had a data plan. Cellular service was inconsistently obtained with data packages or Wi-Fi. 30% of participants had no experience using WhatsApp.

Conclusions
Participants identified numerous health information needs, which will serve as the content for our planned digital support group and provides valuable insight for health care providers globally. Less than half of participants had consistent cellular phone access, and none had reliable access to cellular service.
The role of e-health in improving control and management of COVID 19 outbreak: current perspectives
Authors: Al-Ruzzieh Majeda A , Ayaad Omar , Qaddumi Bayan 
Published: September 2020

Abstract
E-health could play an important role in the global response to Coronavirus disease 2019 (COVID-19). This paper aims to outline the roles of using e-health in the control and management of COVID-19 based on current perspectives. Many databases and health organizations were searched. The results indicated that there are significant roles of e-health in strengthening the efforts to control and manage this COVID-19 pandemic through improving safe coordination and communication, affording an alternative for education and training, analyzing the data, and providing safe care. Further studies are recommended to evaluate the role of e-health in the control and management of COVID-19.
Human papillomavirus vaccine series follow-through: comparison of four clinics in an academic medical center
Authors: McRea Abigail , Moore Brittney , Morris Hannah , Cortright Lindsay , Buckman Cierra , Tumin Dmitry , Baker K. Drew 
Published: September 2020

Abstract

Objective
The Centers for Disease Control & Prevention (CDC) recommends that the human papillomavirus (HPV) vaccine series be initiated at ages 11–12 years, but many children never follow-through with the series. By examining differences in clinic-specific vaccine series follow-through rates across four clinics, we aimed to identify best practices related to communication around the vaccine and pathways to follow-through.

Methods
We used the electronic medical record (EMR) to retrospectively analyze HPV vaccine follow-through at four clinic settings. We limited the sample to children ages 11–17 who received a dose of the vaccine series at any of the clinics between January 2015 and June 2018. The primary outcome was follow-through of the HPV vaccine series within 18 months of initiation.

Results
A total of 3,813 patients were included in this study, 29% of which followed through with the HPV vaccine series. There was significant variability of vaccine follow-through among the clinics (p<0.001), with the Med/Peds clinic having the highest rate of follow-through (32%). After adjusting for confounding variables, multivariable analysis found that Med/Peds and Family Medicine had higher odds of HPV vaccine series follow-through than the Pediatrics clinic.

Conclusions
We found that the likelihood of vaccine series follow-through was highest when the series was started in the Med/Peds and Family Medicine clinics, compared to Pediatrics and Adolescent Medicine. These results suggest that further qualitative research is needed to understand what communication strategies are most effective at facilitating HPV vaccine uptake among adolescents, and how the most effective strategies can be shared among clinics.
Two-stage receiver operating-characteristic curve estimator for cohort studies
Authors: Díaz-Coto Susana , Corral-Blanco Norberto Octavio , Martínez-Camblor Pablo 
Published: September 2020

AbstractThe receiver operating-characteristic (ROC) curve is a graphical statistical tool routinely used for studying the classification accuracy in both, diagnostic and prognosis problems. Given the different nature of these situations, ROC curve estimation has been separately considered for binary (diagnostic) and time-to-event (prognosis) outcomes, even for data coming from the same study design. In this work, the authors propose a two-stage ROC curve estimator which allows to link both contexts through a general prediction model (first-stage) and the empirical cumulative estimator of the distribution function (second-stage) of the considered test (marker) on the total population. The so-called two-stage Mixed-Subject (sMS) approach proves its behavior on both, large-samples (theoretically) and finite-samples (via Monte Carlo simulations). Besides, a useful asymptotic distribution for the concomitant area under the curve is also computed. Results show the ability of the proposed estimator to fit non-standard situations by considering flexible predictive models. Two real-world examples, one with binary and one with time-dependent outcomes, help us to a better understanding of the proposed methodology on usual practical circumstances. The R code used for the practical implementation of the proposed methodology and its documentation is provided as supplementary material.
Development of thermal model for estimation of core temperature of batteries
Authors: Surya Sumukh , Bhesaniya Amit , Gogate Aditya , Ankur Raghav , Patil Vineeth 
Published: September 2020

AbstractCore temperature (Tc) estimation plays an important in role in establishing an effective thermal management system of a battery. In the present work, Tc of a lead acid (Pb) battery was estimated using a Kalman filter, based on a thermal model of the battery using convection resistances and capacitances. The governing equations based on measured surface temperature (Ts) and ambient temperature (Tamb) were derived. Since Tc cannot be measured directly, estimation technique was used to predict the same using measured Ts and Tamb. Five test cases for which the profiles of Tc versus time were available were analyzed. It was found that the errors in the predictions varied from 0.25 °C to 3.5 °C., depending on the nature of Tc profiles, with minimum errors when Tc has slow variations with time.
Improved stability of steerable sheath access by femoro-femoral crossover wire in branched stent graft repair of complex thoraco-abdominal aortic aneurysms
Authors: Töpel Ingolf , Betz Thomas , Steinbauer Markus , Uhl Christian 
Published: September 2020

Abstract

Purpose
The purpose of this study was to describe a technique to catheterize antegrade branches of a branched aortic endograft by using a steerable sheath stabilized by a through-and-through wire via a femoral access.

Technique
After implantation of a branched endovascular graft, a steerable 8.5 F sheath is advanced from the femoral access. After placing the sheath proximal to the branches, a 0.014″ through-and-through wire is established to the contralateral femoral access which is held under slight traction after the curved tip of the sheath is brought into the 180° position. Then catheterization, wire exchange and deployment of the bridging stent is done in standard fashion.

Conclusion
The use of a through-and-through wire with a steerable sheath for retrograde femoral access adds stability and precision to this technique. It has the potential to reduce the risk of preoperative stroke in complex aortic endovascular repair by avoiding upper extremity access.
The Inaugural Bible: Presidential Rhetoric and the Politics of Scripture
Authors: von Ehrenkrook Jason 
Published: September 2020

AbstractThis article examines the reception of Scripture in presidential inaugurations, considering both the Bible as a material object within the oath of office ceremony and the Bible as a source of rhetoric within the inaugural address. Data from select presidential archives are also included in this study, especially letters from citizens, which offer a useful glimpse into the public impact of scriptural rhetoric. The broad chronological parameters of the data, which encompass 58 inauguration ceremonies from George Washington to Donald Trump, permit analysis of the varied functions of Scripture within the inaugural ceremony alongside consideration of larger diachronic trends. Analysis of this data underscores the capacity of the Bible to operate as a useful and remarkably flexible political tool that infuses this important transition of power with an aura of sanctity and divine authority. Appropriation of this ancient text functions to sacralize modern political speech, to fan the flames of American patriotism, to reinforce and enhance executive power, to facilitate efforts to persuade the public on a wide range of political agendas, and to furnish a language that justifies a variety of domestic and global policies. The inaugural Bible thus demonstrates the extent to which Scripture remains inextricably woven into the tapestry of American political discourse.
Effect of Sudarshan Kriya Yoga (SKY) on daytime and situational sleep propensity in novice practitioners: a prospective cohort study
Authors: Chaudhari Kaustubh S. , Chaudhari Saurabh S. , Rankhambe Harshali B. , Kochupillai Vinod , Tiwari Rakesh R. 
Published: September 2020

AbstractObjectivesHectic, late-night lifestyle has reduced 90 min sleep in 20% adults resulting in insomnia and excessive daytime sleepiness (EDS). We assess the scope of Sudarshan Kriya Yoga (SKY), a 4-component, breathing process in reducing EDS, generally and situationally.MethodsThis is a prospective, controlled study involving randomized subjects without any sleep-wake cycle anomalies and prior experience in SKY. Subjects (n=52) performed 30 min of SKY for 6 days/week for 8 weeks, while controls (n=53) performed sitting activity and Suryanamaskar for 4-weeks each. Epworth Sleepiness Scale (ESS) was used to measure EDS at 0, 4, and 8 weeks.ResultsSKY group showed significant ESS score improvements between 0–4 weeks and 4–8 weeks of 1.22 (p=0.0001) and 1.66 (p=0.001) respectively. Controls however failed to improve with score differences of 0.02 (p=0.892) and 0.02 (p=0.8212) respectively. SKY group showed significant ESS score improvement over controls at 4-weeks (difference=1.74; p=0.013) and 8-weeks (difference eight; p=0.0001). Improvement was most for obese people and those sitting in a halted car.ConclusionsImprovement in subjects’ nighttime sleep and daytime wakefulness in SKY practitioners can be attributed to polyvagal theory. Increased heart rate variability (HRV) alterations and sympathetic hyperarousal in chronic insomnia; and cholinergic and GABAergic dysregulation in anxiety disorders are countered by regulated vagal nerve stimulation post SKY. Our study establishes effectivity of SKY in reducing EDS (total and situational), provides a clinical correlation for prior polysomnographic evidence and paves way for larger trials directed towards SKY prescriptions for insomnia.
Geo-information system of tuberculosis spread based on inversion and prediction
Authors: Kabanikhin Sergey , Krivorotko Olga , Takuadina Aliya , Andornaya Darya , Zhang Shuhua 
Published: September 2020

Abstract
The monitoring, analysis and prediction of epidemic spread in the region require the construction of mathematical model, big data processing and visualization because the amount of population and the size of the region could be huge. One of the important steps is refinement of mathematical model, i.e. determination of initial data and coefficients of system of differential equations of epidemiologic processes using additional information. We analyze numerical method for solving inverse problem of epidemiology based on genetic algorithm and traditional optimization approach. Our algorithms are applied to analysis and prediction of epidemic situation in regions of Russian Federation, Republic of Kazakhstan and People’s Republic of China. Due to a great amount of data we use a special software ”Digital Earth” for visualization of epidemic.
Numerically statistical investigation of the partly super-exponential growth rate in the COVID-19 pandemic (throughout the world)
Authors: Lotova Galiya Z. , Mikhailov Guennady A. 
Published: September 2020

Abstract
A number of particles in a multiplying medium under rather general conditions is asymptotically exponential with respect to time t with the parameter λ, i.e., with the index of power

λ
⁢
t

{\lambda t}

. If the medium is random, then the parameter λ is the random variable. To estimate the temporal asymptotics of the mean particles number (via the medium realizations), it is possible to average the exponential function via the corresponding distribution. Assuming that this distribution is Gaussian, the super-exponential estimate of the mean particle number could be obtained and expressed by the exponent with the index of power

t
⁢
E
⁢
λ

+

t
2

⁢
D
⁢

λ
2

{t{\rm E}\lambda+t^{2}{\rm D}\frac{\lambda}{2}}

. The application of this new formula to investigation of the COVID-19 pandemic is performed.
Global and local optimization in identification of parabolic systems
Authors: Krivorotko Olga , Kabanikhin Sergey , Zhang Shuhua , Kashtanova Victoriya 
Published: September 2020

Abstract
The problem of identification of coefficients and initial conditions for a boundary value problem for parabolic equations that reduces to a minimization problem of a misfit function is investigated.
Firstly, the tensor train decomposition approach is presented as a global convergence algorithm.
The idea of the proposed method is to extract the tensor structure of the optimized functional and use it for multidimensional optimization problems.
Secondly, for the refinement of the unknown parameters, three local optimization approaches are implemented and compared: Nelder–Mead simplex method, gradient method of minimum errors, adaptive gradient method.
For gradient methods, the evident formula for the continuous gradient of the misfit function is obtained.
The identification problem for the diffusive logistic mathematical model which can be applied to social sciences (online social networks), economy (spatial Solow model) and epidemiology (coronavirus COVID-19, HIV, etc.) is considered.
The numerical results for information propagation in online social network are presented and discussed.
Screening for imprinting disorders in 58 patients with clinically diagnosed idiopathic short stature
Authors: Kawashima Sayaka , Yagi Hiroko , Hirano Yasuhiro , Toki Machiko , Izumi Kei , Dateki Sumito , Namba Noriyuki , Kamimaki Tsutomu , Muroya Koji , Tanaka Toshiaki , Fukami Maki , Kagami Masayo 
Published: September 2020

Abstract

Objectives
Imprinted genes have important roles for normal growth and development. Imprinting disorders (IDs) such as Silver-Russell syndrome and Temple syndrome are rare diseases that typically cause short children born small for gestational age (SGA). However, some patients with short stature (SS) caused by IDs were born non-SGA. To date, the contribution of IDs to idiopathic short stature (ISS) has been poorly investigated. The aim of this study was to clarify the contribution of IDs to ISS.

Methods
We conducted methylation analysis for 10 differentially methylated regions using pyrosequencing to detect known IDs in 58 patients (31 male and 27 female children, height standard deviation score −4.2 to −2.0) carrying a clinical diagnosis of ISS.

Results
We identified no patient with IDs among these patients with ISS.

Conclusions
These results indicate that IDs are rare in patients having ISS, and that imprinted genes affect fetal growth more than postnatal growth. Because patients with IDs born non-SGA usually have clinical features characteristic of each ID, in addition to SS, the patients with ISS as a clinical diagnosis may not be associated with IDs.
It is unlikely that cases clinically diagnosed with ISS are caused by IDs leading to growth failure.