bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrophobic Modification of Microenvironment of Highly Dispersed Co3O4 Nanoparticles for the Catalytic Selective Oxidation of Ethylbenzene
Authors: Zhao Li , Shi Song , Liu Meng , Chen Chen , Zhu Guozhi , Gao Jin , Xu Jie 
Published: October 2019

AbstractMicroenvironments in enzymes play crucial roles in controlling the activities of active centers. Here, hexagonal mesoporous silicas (HMS) with hydrophobic microenvironment was used to mimic the enzymes on the hydrocarbon oxidation with cobalt oxides incorporated as active sites. The variation of the structure and surface properties of the materials with phenyl group incorporation and the state of the supported cobalt oxides were carefully studied. It showed that cobalt oxides presented as Co3O4 distributed evenly among the support, and the catalytic microenvironment was modified by the neighboring phenyl groups to be hydrophobic. This novel catalyst showed enhancement in the adsorption of ethylbenzene and in turn promoted the catalytic conversion than the hydrophilic one. 55.1 % conversion of ethylbenzene and 86.1 % selectivity for acetophenone could be obtained at 393 K for 6 h under 1.0 MPa of O2 with free solvent. Hydrophobic microenvironment of pore surface was considered as an important factor for the better catalytic activity.
Early Main Group Metal Catalysts for Imine Hydrosilylation
Authors: Elsen Holger , Fischer Christian , Knüpfer Christian , Escalona Ana , Harder Sjoerd 
Published: October 2019

AbstractThe efficient catalytic reduction of imines with phenylsilane is achieved by using the potassium, calcium and strontium based catalysts [(DMAT)K (THF)]∞, (DMAT)2Ca⋅(THF)2 and (DMAT)2Sr⋅(THF)2 (DMAT=2‐dimethylamino‐α‐trimethylsilylbenzyl). Eight different aldimines and the ketimine Ph2C=NPh could be successfully reduced by PhSiH3 at temperatures between 25–60 °C with catalyst loadings down to 2.5 mol %. Also, simple amides like KN(SiMe3)2 or Ae[N(SiMe3)2]2 (Ae=Ca, Sr, Ba) catalyze this reaction. Activities increase with metal size. For most substrates the activity increases along the row K<Ca<Sr<Ba. Fastest conversion was found for imines with alkyl substituents at N and aryl rings at C, for example, PhC(H)=NtBu, while tBuC(H)=NtBu or PhC(H)=NPh react much slower. Reasonable functional group tolerance is observed. The proposed metal hydride mechanism is supported by stoichiometric reactions using a catalyst model system, isolation of intermediates and DFT calculations.
Amphoteric Homotropic Allosteric Association between a Hexakis‐Urea Receptor and Dihydrogen Phosphate
Authors: Kondo Seiya , Masuda Junya , Komiyama Tomoki , Yasuda Nobuhiro , Takaya Hikaru , Yamanaka Masamichi 
Published: October 2019

AbstractConformationally flexible hexakis‐urea 1 was synthesized efficiently by condensing hexakis(aminomethyl)benzene with 4‐nitrophenyl‐(3,5‐di‐tert‐butylphenyl)carbamate. The hexakis‐urea 1 is unexpectedly soluble in organic solvents of low polarity due to intramolecular hydrogen bonding. The hexakis‐urea 1 recognizes chloride, bromide, and acetate in a 1:2 host‐guest ratio and in a positive allosteric manner in CDCl3. The ability of 1 to recognize dihydrogen phosphate is a unique outcome, and the structure of the associated complex, which contains four dihydrogen phosphate ions, was clarified by single‐crystal X‐ray structural analysis. However, in solution, a complex with three dihydrogen phosphate ions was identified. The dihydrogen phosphate association in CDCl3 proceeds in an amphoteric allosteric manner; in a positive allosteric manner (K1<K2) in the first step and a negative allosteric manner (K2>K3) in the subsequent step.
Verification of the coupled‐momentum method with Womersley's Deformable Wall analytical solution
Authors: Filonova Vasilina , Arthurs Christopher J. , Vignon‐Clementel Irene E. , Figueroa C. Alberto 
Published: October 2019

AbstractIn this paper, we perform a verification study of the Coupled‐Momentum Method (CMM), a 3D fluid‐structure interaction (FSI) model which uses a thin linear elastic membrane and linear kinematics to describe the mechanical behavior of the vessel wall. The verification of this model is done using Womersley's deformable wall analytical solution for pulsatile flow in a semi‐infinite cylindrical vessel. This solution is, under certain premises, the analytical solution of the CMM and can thus be used for model verification. For the numerical solution, we employ an impedance boundary condition to define a reflection‐free outflow boundary condition and thus mimic the physics of the analytical solution, which is defined on a semi‐infinite domain. We first provide a rigorous derivation of Womersley's deformable wall theory via scale analysis. We then illustrate different characteristics of the analytical solution such as space‐time wave periodicity and attenuation. Finally, we present the verification tests comparing the CMM with Womersley's theory.
Designing a QTL Mapping Study for Implementation in the Realized Collaborative Cross Genetic Reference Population
Authors: Soller Morris , Abu‐Toamih Atamni Hanifa J. , Binenbaum Ilona , Chatziioannou Aristotelis , Iraqi Fuad A. 
Published: October 2019

AbstractThe Collaborative Cross (CC) mouse resource is a next‐generation mouse genetic reference population (GRP) designed for high‐resolution mapping of quantitative trait loci (QTL) of large effect affecting complex traits during health and disease. The CC resource consists of a set of 72 recombinant inbred lines (RILs) generated by reciprocal crossing of five classical and three wild‐derived mouse founder strains. Complex traits are controlled by variations within multiple genes and environmental factors, and their mutual interactions. These traits are observed at multiple levels of the animals’ systems, including metabolism, body weight, immune profile, and susceptibility or resistance to the development and progress of infectious or chronic diseases. Herein, we present general guidelines for design of QTL mapping experiments using the CC resource—along with full step‐by‐step protocols and methods that were implemented in our lab for the phenotypic and genotypic characterization of the different CC lines—for mapping the genes underlying host response to infectious and chronic diseases. © 2019 by John Wiley & Sons, Inc.Basic Protocol 1: CC lines for whole body mass index (BMI)Basic Protocol 2: A detailed assessment of the power to detect effect sizes based on the number of lines used, and the number of replicates per lineBasic Protocol 3: Obtaining power for QTL with given target effect by interpolating in Table 1 of Keele et al. (2019)
Four‐ and Five‐Coordinate Titanium(IV) Complexes Supported by the dpp‐bian Ligand in ROP of L‐Lactide
Authors: Morozov Alexander G. , Martemyanova Tatyana V. , Dodonov Vladimir A. , Kazarina Olga V. , Fedushkin Igor L. 
Published: October 2019

AbstractInvited for the cover of this issue is Dr. Alexander Morozov from the G.A. Razuvaev Institute of Organometallic Chemistry of the Russian Academy of Sciences, Nizhny Novgorod, Russian Federation. The cover image shows two basketball players representing the bis(amide) and the radical anionic ligands, with different modes of binding to the Ti metal.
Diagnostic and interventional implications of telemedicine in Alzheimer's disease and mild cognitive impairment: A literature review
Authors: Costanzo Maria Cristina , Arcidiacono Chiara , Rodolico Alessandro , Panebianco Mariangela , Aguglia Eugenio , Signorelli Maria Salvina 
Published: October 2019

IntroductionWorldwide, life expectancy, and aging‐related disorders as mild cognitive impairment (MCI) and Alzheimer disease (AD) are increasing, having a rising impact on patients' quality of life and caregivers' distress. Telemedicine offers many possibilities, such as remote diagnosing and monitoring of patients.ObjectiveThe purpose of this study is to provide a narrative synthesis of the literature about the implementation of telemedicine for diagnosis, treatment, and follow‐up of patients with AD and MCI and their caregivers.MethodsA systematic literature review was conducted on MEDLINE, EMBASE, and the Cochrane Library databases up to September 2018. MCI or AD diagnoses were the conditions of interest. We excluded other dementias.ResultsFifty‐six articles met inclusion criteria. We identified two main categories: diagnosis group (DG) and follow‐up/interventional group (FIG). Fifteen articles suggested how to make a remote or earlier diagnosis: four were case‐control accuracy studies, nine were paired comparative accuracy studies, and two were prospective single‐arm accuracy studies. Among these, four focused on MCI, six on AD, and five on both. Forty one focused on supporting patients during the stages of the disease (28 articles), patient's caregivers (nine articles), or both (four articles).ConclusionsThe rising use of telemedicine could actively improve AD and MCI patients' lives, reduce caregivers' burden, and facilitate an early diagnosis if patients live in remote places. However, as some studies report, it is relevant to take into account the emotional impact of telemedicine on patients and not only on the effectiveness.
The infraclavicular pedicled flap in head and neck reconstruction: applications and outcomes
Authors: Alain Charles , Fortier Pierre‐Hugues , Belzile Mathieu 
Published: October 2019

AbstractBackgroundAn infraclavicular pedicled flap (ICPF) was recently described in the literature. This anatomical region is attractive for the restoration of head and neck oncological defects. This paper is a review of our experience with this versatile flap.MethodsA retrospective study was conducted by reviewing the records of all the patients operated in a tertiary‐care center between August 2013 and January 2019 whose surgery involved an ICPF.ResultsForty‐four patients received an ICPF for various indications, including large vessel coverage in neck/parotid recontouring (34.1%), postlaryngectomy reconstruction (34.1%), and fistula closure (25.0%). All flaps survived. Thirteen patients experienced a postoperative complication (29.5%), six of whom (13.9%) required a repeat procedure under general anesthesia.ConclusionICPF is suitable for several indications and is a useful adjunctive tool in head and neck reconstruction. It proved to have a high survival rate, with complication rates similar to other regional flaps.
Employee well‐being attribution and job change intentions: The moderating effect of task idiosyncratic deals
Authors: Lee Byron Y. , Kim Tae‐Yeol , Gong Yaping , Zheng Xiaoming , Liu Xin 
Published: October 2019

AbstractWe developed and tested a research model in which employee well‐being human resource (HR) attribution differentially influences the intention to change jobs across organizations (i.e., external job change intention) versus that within the same organization (i.e., internal job change intention). Furthermore, we posited that task idiosyncratic deals (I‐deals) moderated the relationships between employee well‐being HR attribution and external and internal job change intentions. Results indicated that employee well‐being HR attribution was negatively related to external job change intention, but positively related to internal job change intention. Further, task I‐deals significantly moderated the relationships between employee well‐being HR attribution and external and internal job change intention. Specifically, employee well‐being HR attribution played a less important role in reducing external job change intention when task I‐deals were high rather than low. On the other hand, high task I‐deals significantly strengthened the positive relationship between employee well‐being HR attribution and internal job change intention. Our study extends the careers literature by differentiating the impact of employee well‐being HR attribution on job change intentions within an organization compared with that across organizations and the important role of supervisors in enhancing or mitigating these effects.
Multiple sparse priors technique with optimized patches for brain source localization
Authors: Jatoi Munsif Ali , Kamel Nidal , López José D. 
Published: October 2019

AbstractLocalizing brain neural activity using electroencephalography (EEG) neuroimaging technique is getting increasing response from neuroscience researchers and medical community. It is due to the fact that brain source localization has a variety of applications for diagnoses of various brain disorders. This problem is ill‐posed in nature because an infinite number of source configurations can produce the same potential at the head surface. Recently, a new technique that is based on Bayesian framework, called the multiple sparse priors (MSP), was proposed as a solution to this problem. The MSP develops the solution for source localization using the current densities associated with dipoles in terms of prior source covariance matrix and sensor covariance matrix, respectively. Then, it uses the maximization of the cost function of the free energy under the assumption of a fixed number of hyperparameters or patches in order to obtain the elements of prior source covariance matrix. This research work aims to further enhance the maximization process of MSP with regard to the free energy by considering a variable number of patches. This will lead to a better estimation of brain sources in terms of localization errors. The performance of the modified MSP with a variable number of patches is compared with the original MSP using simulated and real‐time EEG data. The results show a significant improvement in terms of localization errors.
Detection of pulmonary micronodules in computed tomography images and false positive reduction using 3D convolutional neural networks
Authors: Gupta Anindya , Saar Tonis , Martens Olev , Le Moullec Yannick , Sintorn Ida‐Maria 
Published: October 2019

AbstractManual detection of small uncalcified pulmonary nodules (diameter <4 mm) in thoracic computed tomography (CT) scans is a tedious and error‐prone task. Automatic detection of disperse micronodules is, thus, highly desirable for improved characterization of the fatal and incurable occupational pulmonary diseases. Here, we present a novel computer‐assisted detection (CAD) scheme specifically dedicated to detect micronodules. The proposed scheme consists of a candidate‐screening module and a false positive (FP) reduction module. The candidate‐screening module is initiated by a lung segmentation algorithm and is followed by a combination of 2D/3D features‐based thresholding parameters to identify plausible micronodules. The FP reduction module employs a 3D convolutional neural network (CNN) to classify each identified candidate. It automatically encodes the discriminative representations by exploiting the volumetric information of each candidate. A set of 872 micro‐nodules in 598 CT scans marked by at least two radiologists are extracted from the Lung Image Database Consortium and Image Database Resource Initiative to test our CAD scheme. The CAD scheme achieves a detection sensitivity of 86.7% (756/872) with only 8 FPs/scan and an AUC of 0.98. Our proposed CAD scheme efficiently identifies micronodules in thoracic scans with only a small number of FPs. Our experimental results provide evidence that the automatically generated features by the 3D CNN are highly discriminant, thus making it a well‐suited FP reduction module of a CAD scheme.
Bladder tissue characterization using probe‐based Raman spectroscopy: Evaluation of tissue heterogeneity and influence on the model prediction
Authors: Cordero Eliana , Rüger Jan , Marti Dominik , Mondol Abdullah S. , Hasselager Thomas , Mogensen Karin , Hermann Gregers G. , Popp Jürgen , Schie Iwan W. 
Published: October 2019

AbstractExisting approaches for early‐stage bladder tumor diagnosis largely depend on invasive and time‐consuming procedures, resulting in hospitalization, bleeding, bladder perforation, infection and other health risks for the patient. The reduction of current risk factors, while maintaining or even improving the diagnostic precision, is an underlying factor in clinical instrumentation research. For example, for clinic surveillance of patients with a history of noninvasive bladder tumors real‐time tumor diagnosis can enable immediate laser‐based removal of tumors using flexible cystoscopes in the outpatient clinic. Therefore, novel diagnostic modalities are required that can provide real‐time in vivo tumor diagnosis. Raman spectroscopy provides biochemical information of tissue samples ex vivo and in vivo and without the need for complicated sample preparation and staining procedures. For the past decade there has been a rise in applications to diagnose and characterize early cancer in different organs, such as in head and neck, colon and stomach, but also different pathologies, for example, inflammation and atherosclerotic plaques. Bladder pathology has also been studied but only with little attention to aspects that can influence the diagnosis, such as tissue heterogeneity, data preprocessing and model development. The present study presents a clinical investigative study on bladder biopsies to characterize the tumor grading ex vivo, using a compact fiber probe‐based imaging Raman system, as a crucial step towards in vivo Raman endoscopy. Furthermore, this study presents an evaluation of the tissue heterogeneity of highly fluorescent bladder tissues, and the multivariate statistical analysis for discrimination between nontumor tissue, and low‐ and high‐grade tumor.
Bioengineering strategies for bone and cartilage tissue regeneration using growth factors and stem cells
Authors: Qasim Muhammad , Chae Dong Sik , Lee Nae Yoon 
Published: October 2019

AbstractBone and cartilage tissue engineering is an integrative approach that is inspired by the phenomena associated with wound healing. In this respect, growth factors have emerged as important moieties for the control and regulation of this process. Growth factors act as mediators and control the important physiological functions of bone regeneration. Herein, we discuss the importance of growth factors in bone and cartilage tissue engineering, their loading and delivery strategies, release kinetics, and their integration with biomaterials and stem cells to heal bone fractures. We also highlighted the role of growth factors in the determination of the bone tissue microenvironment based on the reciprocal signaling with cells and biomaterial scaffolds on which future bone and cartilage tissue engineering technologies and medical devices will be based upon.
Effects of crocin in reducing DNA damage, inflammation, and oxidative stress in multiple sclerosis patients: A double‐blind, randomized, and placebo‐controlled trial
Authors: Ghiasian Masoud , Khamisabadi Forough , Kheiripour Nejat , Karami Manouchehr , Haddadi Rasool , Ghaleiha Ali , Taghvaei Babak , Oliaie Seyed Sajad , Salehi Mohammadjavad , Samadi Pouria , Ranjbar Akram 
Published: October 2019

AbstractMultiple sclerosis (MS) is an autoimmune disease in which the immune system attacks the nerve cells, resulting in neurological disorders. Oxidative stress, free radicals, and neuritis have important roles in MS pathogenesis. Here, we aim to evaluate the effect of crocin on inflammatory markers, oxidative damage, and deoxyribonucleic acid (DNA) damage in the blood of patients with MS. A total of 40 patients were divided into two groups, drug and placebo‐treated groups, using random assignment. Participants of the intervention and control groups received two crocin capsules or placebo per day for 28 days, respectively. Findings revealed a significant decrease in the level of important pathogenic factors in MS, including lipid peroxidation, DNA damage, tumor necrosis factor‐alpha, and interleukin 17 as well as a significant increase in the total antioxidant capacity in the serum of patients treated with crocin compared with the placebo group. Our results suggest the beneficial and therapeutic effects of crocin in MS.
Evaluate performance of the Abbott chemiluminescent microparticle immunoassay assay for detection of syphilis infection in Chinese blood donors
Authors: Fu Ping , Devare Sushil , Liu Jian‐fang , Lv Xiao‐ting , Yin Peng , Wu Bing‐ting , Ke Ling , Liu Yu , Shan Hua 
Published: October 2019

AbstractBackground and ObjectivesTo prevent Treponema Pallidum (TP) transmission from blood transfusion, enzyme‐linked immunosorbent assay (EIA) for anti‐TP has been widely used in routine blood donation screening in China for many years. The aim of this study was to evaluate the performance of the Abbott CMIA assay for detection of anti‐TP in Chinese blood donors.Materials and methodsA total of 2420 plasma samples, already routinely screened for anti‐TP by two different EIAs, from four blood Centers were tested for anti‐TP by Abbott CMIA. Subsequently, all samples with positive results by one or both EIAs and/or by Abbott CMIA were subjected to confirmatory testing (CT) using recombinant immunoblot assay (RIBA) or Treponema Pallidum particle agglutination assay (TPPA). TP infection was defined by a RIBA or TPPA positive.ResultsCompared with two EIAs strategy, Abbott CMIA showed a relatively best sensitivity as 98.80% (95% CI: 97.44%‐100.16%) and a relatively best specificity as 99.58% (95% CI: 99.30%‐99.85%), yielding the best consistency (99.49%) between anti‐TP CT results with the highest κ value of .98.ConclusionThis is the first study to evaluate the performance of the Abbott CMIA assays for detection of syphilis in Chinese blood donors. Our results suggested that CMIA performed better than both EIAs, and implementation of CMIA replacing two different EIA reagents might help to further reduce the risk of transfusion‐transmitted TP infection, decrease unnecessary blood waste and loss of blood donors.
Oxidative stress enhances the immune response to oxidatively modified catalase enzyme in patients with Graves’ disease
Authors: Gargouri Bochra , Mseddi Malek , Mnif Fatma , Abid Mohamed , Attia Hamadi , Lassoued Saloua 
Published: October 2019

AbstractBackgroundOxidative stress is associated with several autoimmune disorders and oxidative modification of proteins that may result in autoimmune response. This study aims to evaluate the catalase (CAT) activity and the autoimmune response against the native CAT and the oxidatively modified enzyme in patients with Graves' disease (GD) and healthy controls in a comparative way.MethodsThe CAT activity was evaluated via spectrophotometric method. Using enzyme‐linked immunosorbent assay, the reactivities of autoantibody toward native, malondialdehyde (MDA) and hydrogen peroxide (H2O2) modified CAT were evaluated in plasmas of patients and controls.ResultsReduced CAT activity was found in patients compared with controls (P < .05). It was proved that levels of IgG antibodies against MDA‐modified CAT were higher than against unmodified ones (P < .001). No changes were found for the reactivities to H2O2‐modified CAT. Positive correlation was found between the reactivity to MDA‐modified CAT and the triiodothyronine level (P < .001,r = .6).ConclusionOur findings incriminate the MDA in the autoantibodies reactivity to oxidatively modified CAT leading to a disturbed oxidative profile and/or the progression of GD pathology.