bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantenphysik in der Schule – Was benötigen Lehrkräfte? Ergebnisse einer Delphi-Studie
Authors: Weber Kim-Alessandro , Friege Gunnar , Scholz Rüdiger 
Published: October 2020

ZusammenfassungDas Themengebiet Quantenphysik gilt als gleichermaßen bedeutend wie herausfordernd für den Physikunterricht in der Schule. Die Erzeugung einer empirischen Basis für die Konstruktion von Leitlinien für eine im besonderen Maße adressatenspezifische Lehrerfortbildung zum Thema Quantenphysik ist Gegenstand dieses Beitrags.Die Didaktische Rekonstruktion zur Erarbeitung von Leitlinien für Lehrerfortbildungen leitet die vorgestellte Untersuchung. Basis der Rekonstruktion bilden die Analyse von bestehenden Konzepten zum Quantenphysikunterricht in der Schule und die empirische Erhebung von Sichtweisen der Lehrenden auf diese. Der Fokus liegt in diesem Beitrag auf der Erhebung und Auswertung der Sichtweisen von Lehrenden. Zu diesem Zweck wurde eine iterative Kommunikationstechnik zur Erhebung und Quantifizierung von Expertenmeinungen verwendet, die Delphi-Methode, welche in der fachdidaktischen Forschung etabliert ist.Als Ergebnis der Didaktischen Rekonstruktion werden sechs Leitlinien vorgestellt, die Dozenten bei der Planung und Durchführung der Fortbildung unterstützen. Die Leitlinien implizieren eine Fortbildung, die den Weg von der klassischen zur Quantenphysik beschreitet und dabei Schlüsselexperimente in das Zentrum stellt.
EuGMS 2019 Congress report: evidence-based medicine in geriatrics
Authors: Hope Suzy V. , Koutsouri Anastasia , Nguyen Sylvain , Piotrowicz Karolina , Petrovic Mirko , Gasowski Jerzy 
Published: October 2020

AbstractThe 2019 EuGMS Congress “Evidence-Based Medicine in Geriatrics” was held in Krakow, Poland, and attended by over 1600 participants from 64 different countries. A summary and reflection on the congress was presented in the Closing Ceremony by European Academy for Medicine of Aging graduates, and summarised in this article. Keynote lectures, ‘state of the art’ sessions and symposia presented the evidence relating to different age-related conditions, their prevention, management and treatments. Hot topic areas included frailty and multimorbidity, and evidence-based attempts to address these conditions at different life stages. The field of geriatrics represents unique challenges for evidence-based medicine practice. There is much research going on. Clear leadership is needed to facilitate consensus agreements on standard definitions, methods and relevant outcomes, in collaboration with older people themselves, to maximise the opportunities and benefits of doing this research, and benefiting our patients and society at large.
Ion-Exchange Modeling of Monovalent Alkali Cation Adsorption on Montmorillonite
Authors: Li Yayu W. , Schulthess Cristian P. 
Published: October 2020

AbstractIon-exchange modeling is one of the most widely used methods to predict ion adsorption data on clay minerals. The model parameters (e.g. number of adsorption sites and the cation adsorption capacity of each site) are optimized normally by curve fitting experimental data, which does not definitively identify the local environment of the adsorption sites. A new approach for constructing an ion-exchange model was pursued, whereby some of the parameters needed were obtained independently, resulting in fewer parameters being based on data-curve fitting. Specifically, a reversed modeling approach was taken in which the number of types of sites used by the model was based on a previous first-principles Density Functional Theory study, and the relative distribution of these sites was based on the clay’s chemical composition. To simplify the ion-exchange reactions involved, montmorillonite was Na-saturated to produce a well-controlled Na-montmorillonite (NaMnt) adsorbent. Ion adsorption data on NaMnt were collected from batch experiments over a wide range of pH, Cs+ concentrations, and in the presence of coexisting cations. Ion-exchange models were developed and optimized to predict these cation adsorption data on NaMnt. The maximum amount of adsorption of monovalent cations on NaMnt was obtained from the plateau of the adsorption envelope data at high pH. The remaining equilibrium constants (pK) were optimized by curve fitting the edges of the adsorption envelope data. The resultant three-site ion-exchange model was able to predict the retention of Li+, Na+, K+, and Cs+ very well as a function of pH. The model was then tested on adsorption envelopes of various combinations of these cations, and on Cs+ adsorption isotherms at three different pH values. The pK values were constant for all assays. The interlayer spacing of NaMnt was also analyzed to investigate its relation with cation adsorption strength. An X-ray diffraction study of the samples showed that the measured d001 values for these cations were consistent with their adsorption pK values. The Cs+ cation showed a strong ability to collapse the interlayer region of montmorillonite. In the presence of multiple competing cations, the broadening and presence of multiple d001 XRD peaks suggested that the cations in the interlayers may be segregated.
Does Industry Timing Ability of Hedge Funds Predict Their Future Performance, Survival, and Fund Flows?
Authors: Bali Turan G. , Brown Stephen J. , Caglayan Mustafa O. , Celiker Umut 
Published: October 2020

AbstractThis paper investigates hedge funds’ ability to time industry-specific returns and shows that funds’ timing ability in the manufacturing industry improves their future performance, probability of survival, and ability to attract more capital. The results indicate that the best industry-timing hedge funds in the manufacturing sector have the highest return exposure to earnings surprises. This, together with persistently sticky earnings surprises, transparent information environment in regards to earnings releases, and large post-earnings-announcement drift in the manufacturing industry, explain to a great extent why best-timing hedge funds can generate significantly larger future returns compared to worst-timing hedge funds.
Recurrence rates in stable bipolar disorder patients after drug discontinuation v. drug maintenance: a systematic review and meta-analysis
Authors: Kishi Taro , Matsuda Yuki , Sakuma Kenji , Okuya Makoto , Mishima Kazuo , Iwata Nakao 
Published: October 2020

AbstractBackgroundThis random-effects model meta-analysis of double-blind, randomized placebo-controlled trials compared recurrence rates in bipolar disorder (BD) patients between antipsychotic/mood stabilizer discontinuation and maintenance groups.MethodsWe conducted systematic literature search of Embase, PubMed, and CENTRAL databases without language restriction from inception until 22 May 2020. Independent investigators assessed studies and extracted data. We calculated risk ratios (RRs) and numbers needed to benefit or harm (NNTB/NNTH). Primary outcome was the recurrence rate of any mood episode at 6 months. Secondary outcomes were recurrence rates of depressive episodes and manic/hypomanic/mixed episodes and all-cause discontinuation at 6 months. We also investigated these outcomes at 1, 3, 9, 12, 18, and 24 months.ResultsWe identified 22 studies (n = 5462) receiving aripiprazole, asenapine, divalproex, long-acting injectable (LAI)-aripiprazole, LAI-risperidone, lamotrigine, lithium, olanzapine, paliperidone, or quetiapine. Mean study duration was 64.50 ± 69.35 weeks. The maintenance group demonstrated lower recurrence rates of any mood episode, depressive episodes, and manic/hypomanic/mixed episodes as well as reduced all-cause discontinuation at every observational point. The RRs (95% confidence interval, NNTB/NNTH) of recurrence rate at 6 months were 0.61 (0.54–0.70, 5) for any mood episode, 0.72 (0.60–0.87, 13) for depressive episodes, and 0.45 (0.36–0.57, 6) for manic/hypomanic/mixed episodes. The RR for all-cause discontinuation at 6 months was 0.71 (0.61–0.82, 6).ConclusionsMaintaining drug treatment during clinically stable BD prevented recurrence for up to 24 months. Discontinuation of medications for ⩾1 month significantly increased recurrence risk. However, 47.3% of patients who discontinued drugs for 6 months did not experience recurrence.
A replication study of JTC bias, genetic liability for psychosis and delusional ideation
Authors: Henquet Cécile , van Os Jim , Pries Lotta K. , Rauschenberg Christian , Delespaul Philippe , Kenis Gunter , Luykx Jurjen J. , Lin Bochao D. , Richards Alexander L. , Akdede Berna , Binbay Tolga , Altınyazar Vesile , Yalınçetin Berna , Gümüş-Akay Güvem , Cihan Burçin , Soygür Haldun , Ulaş Halis , Cankurtaran Eylem S. , Kaymak Semra U. , Mihaljevic Marina M. , Petrovic Sanja S. , Mirjanic Tijana , Bernardo Miguel , Mezquida Gisela , Amoretti Silvia , Bobes Julio , Saiz Pilar A. , García-Portilla Maria P. , Sanjuan Julio , Aguilar Eduardo J. , Santos Jose L. , Jiménez-López Estela , Arrojo Manuel , Carracedo Angel , López Gonzalo , González-Peñas Javier , Parellada Mara , Maric Nadja P. , Atbaşoğlu Cem , Ucok Alp , Alptekin Köksal , Saka Meram C. , Arango Celso , O'Donovan Michael , Rutten Bart P.F. , Gülöksüz Sinan 
Published: October 2020

AbstractBackgroundThis study attempted to replicate whether a bias in probabilistic reasoning, or ‘jumping to conclusions’(JTC) bias is associated with being a sibling of a patient with schizophrenia spectrum disorder; and if so, whether this association is contingent on subthreshold delusional ideation.MethodsData were derived from the EUGEI project, a 25-centre, 15-country effort to study psychosis spectrum disorder. The current analyses included 1261 patients with schizophrenia spectrum disorder, 1282 siblings of patients and 1525 healthy comparison subjects, recruited in Spain (five centres), Turkey (three centres) and Serbia (one centre). The beads task was used to assess JTC bias. Lifetime experience of delusional ideation and hallucinatory experiences was assessed using the Community Assessment of Psychic Experiences. General cognitive abilities were taken into account in the analyses.ResultsJTC bias was positively associated not only with patient status but also with sibling status [adjusted relative risk (aRR) ratio : 4.23 CI 95% 3.46–5.17 for siblings and aRR: 5.07 CI 95% 4.13–6.23 for patients]. The association between JTC bias and sibling status was stronger in those with higher levels of delusional ideation (aRR interaction in siblings: 3.77 CI 95% 1.67–8.51, and in patients: 2.15 CI 95% 0.94–4.92). The association between JTC bias and sibling status was not stronger in those with higher levels of hallucinatory experiences.ConclusionsThese findings replicate earlier findings that JTC bias is associated with familial liability for psychosis and that this is contingent on the degree of delusional ideation but not hallucinations.
Exploring the efficacy of music in palliative care: A scoping review
Authors: Nyashanu Mathew , Ikhile Deborah , Pfende Farai 
Published: October 2020

AbstractObjectiveThere is an increasing recognition of the significance of music as a complementary therapy in palliative care. Limited studies exist on how music is used as a coping mechanism by palliative care patients. Therefore, the purpose of this scoping review was to explore the efficacy of music interventions for palliative care.MethodWe conducted a literature search between June and November 2019 in the Cumulative Index of Nursing and Allied Health Literature (CINAHL), British Nursing Index (BNI), and PubMed, which includes MEDLINE. The search identified eight articles which met the inclusion and exclusion criteria.ResultsUsing thematic analysis, six themes were synthesied to show how music contributes to palliative care. The six themes include Pain management; Relaxation; Happiness and hope; Anxiety and depression management; Enhanced spirituality; and Improved quality of life. These themes reflect the psychological and emotional benefits palliative care patients derive from music therapies.Significance of resultsMusic therapy can be an effective psychosocial approach when managing palliative symptoms through its therapeutic effects on physical, psychological, emotional, and spiritual well-being.
Examples of Anglican Ritualism in Victorian South Africa: Towards an Understanding of Local Developments and Practice
Authors: Bethke Andrew-John 
Published: October 2020

AbstractThis article examines South Africa’s contribution to the spread of Anglican ritualism in the mid-nineteenth century and seeks to add a South African voice to the growing contemporary scholarship in this area. It begins by examining the role of South Africa’s first Anglican bishop in fostering a climate conducive to ritualism. This is followed by an examination of some of the early developments which were considered ‘popish’ by colonist congregations. The second part of the study focuses on two examples of advanced ritualist parishes paying attention to ‘signs’ of medievalist revivals and the confident manner in which ritualism was discussed. The author finds that after an initial period of fairly robust antagonism towards ritualism by colonists, a general movement towards ritualist practices began to emerge. The sources consulted for this article include letters, newspaper and periodical articles, archival material and a couple of unpublished theses.
Projections of Mountain Snowpack Loss for Wolverine Denning Elevations in the Rocky Mountains
Authors: Barsugli Joseph J. , Ray Andrea J. , Livneh Ben , Dewes Candida F. , Heldmyer Aaron , Rangwala Imtiaz , Guinotte John M. , Torbit Stephen 
Published: October 2020

AbstractFuture reduction in mountain snowpack due to anthropogenic climate change poses a threat to many snow‐adapted species worldwide. Mountain topography exerts a strong control on snowpack not only due to elevation but also through the effect of slope and aspect on the surface energy balance. We develop high‐resolution projections of snowpack in order to provide improved, physically based estimates of the spatial distribution of future snowpack to inform species conservation efforts for the wolverine (Gulo gulo) in two study areas in the Rocky Mountains: one in Montana with known den sites and one in Colorado with recent wolverine activity and potential for reintroduction. Here we assess springtime snowpack loss in actual and potential denning areas under five future climate scenarios for the mid‐21st century. Snowpack in April and May is likely to persist into the mid‐21st century in the upper half of current denning elevations in all but the warmest future climate scenario, while large declines are projected for the lower half of the denning elevations. We gain new insight into the influence of topographical aspect on future snowpack and quantify the potential for enhanced snow persistence on north and east facing slopes under future scenarios that is only revealed in simulations where terrain slopes are resolved.
Influential Climate Teleconnections for Spatiotemporal Precipitation Variability in the Lancang‐Mekong River Basin From 1952 to 2015
Authors: Irannezhad Masoud , Liu Junguo , Chen Deliang 
Published: October 2020

AbstractThe Lancang‐Mekong River Basin (LMRB) in Mainland Southeast Asia is home to ~70 million people, mostly living in poverty and typically working in primary freshwater‐related sectors, particularly agriculture and fishery. Understanding the mechanisms of the historical variability in precipitation (as the crucial water source) plays a key role in regional sustainable development throughout the LMRB. Herein, the spatiotemporal variability in interannual and intra‐annual precipitation over the LMRB was analyzed using the Global Precipitation Climatology Centre (GPCC) data for the period 1952–2015. The empirical orthogonal function (EOF) and wavelet transform coherence methods were utilized to investigate the relationships of such historical variations in annual (water year: November–October), dry season (November–May), and wet season (June–October) precipitation with 13 different climate teleconnections (eight large‐scale oceanic‐atmospheric circulation patterns and five summer monsoons). On the basin scale, only a significant (p < 0.05) wetting trend in the dry season precipitation (DSP) was uncovered. Spatially, significant wetting (drying) trends in annual precipitation detected over the northeastern (most western) parts of the Mekong River Basin during the water years 1952–2015, largely contributed by the substantial increases (decreases) in historical wet season precipitation. The most important precipitation pattern (EOF1) was identified as a strong (relatively weak) positive center in the eastern (southwestern) Mekong River Basin accompanying by a significantly high (relatively low) positive value for the first EOF mode of the dry season precipitation (wet season precipitation). Precipitation variability in the LMRB was significantly associated with the South Asian Summer Monsoon Index, Southern Oscillation Index, and Indian Summer Monsoon Index.
Quantifying and Numerically Representing Recharge and Flow Components in a Karstified Carbonate Aquifer
Authors: Schuler P. , Duran L. , Johnston P. , Gill L. 
Published: October 2020

AbstractKarstified carbonate aquifers are highly heterogeneous systems characterized by multiple recharge, flow, and discharge components. The quantification of the relative contribution of these components, as well as their numerical representation, remains a challenge. This paper identifies three recharge components in the time and frequency domain. While the analysis in the time domain follows traditional approaches, the analysis of the power spectrum allows frequencies associated with specific spectral coefficients and noise types to be distinguished more objectively. The analysis follows the presented hypothesis that the different frequency‐noise components are the result of aquifer heterogeneity transforming the random rainfall input into a sequence of non‐Gaussian signals. The distinct signals are then numerically represented in the context of a semidistributed pipe network model in order to simulate recharge, flow, and discharge of an Irish karst catchment more realistically. By linking the power spectra of the modeled recharge components with the spectra of the spring discharge, the information usually gained by classical performance indicators is significantly widened. The modeled spring discharge is well matched in the time and frequency domain, yet the different recharge dynamics explain the signal of the aquifer outlet in different noise domains across the spectrum. This study demonstrates the conjunctive use of frequency analysis in conceptualization of a hydrological system together with modeling and evaluation.
Assessing and Managing Large‐Scale Geochemical Impacts From Groundwater Replenishment With Highly Treated Reclaimed Wastewater
Authors: Sun Jing , Donn Michael J. , Gerber Philippe , Higginson Simon , Siade Adam J. , Schafer David , Seibert Simone , Prommer Henning 
Published: October 2020

AbstractReuse of wastewater through a combination of advanced wastewater treatment (AWT) and managed aquifer recharge (MAR) is an important water management option. As an integral part of any AWT‐MAR system, the geochemical compatibility of the recharged water with the targeted aquifer must be assessed to avoid groundwater quality deterioration. Although short‐term field experiments may uncover potentially concerning sediment‐water disequilibria, an advanced analysis is often required to understand the long‐term geochemical impacts of large‐scale MAR. Here, we develop and apply a pragmatic approach to upscale and verify the previously derived local‐scale geochemical understanding to the spatial and temporal scale required for assessing and managing large‐scale and long‐term impacts resulting from the recharge of AWT‐processed water. We use Australia's largest MAR scheme, in which aerobic, purified water is injected into deep, anaerobic, pyritic aquifers as an illustrative example. In this case, the local‐scale understanding was derived from a comprehensive field trial and the interpretation of the data through a trial‐scale high‐resolution reactive transport model (RTM). Based on (i) the trial‐scale RTM, (ii) new data from the early phase of the full‐scale MAR, and (iii) downscaling of an existing, regional‐scale flow model, we developed an upscaled RTM to assess two critical issues for the large‐scale groundwater replenishment of Perth deep aquifers, that is, the sustainability of native pH buffering processes and the dynamics of fluoride release and attenuation. In a final step we illustrate how the upscaled RTM can be applied to assess how changes in the AWT affect long‐term groundwater pH changes.
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
Authors: Jo Myungjin , Lee Shinrye , Jeon Yu-Mi , Kim Seyeon , Kwon Younghwi , Kim Hyung-Jun 
Published: October 2020

AbstractTAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-binding protein involved in the regulation of RNA processing. The accumulation of TDP-43 aggregates in the central nervous system is a common feature of many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and limbic predominant age-related TDP-43 encephalopathy (LATE). Accumulating evidence suggests that prion-like spreading of aberrant protein aggregates composed of tau, amyloid-β, and α-synuclein is involved in the progression of neurodegenerative diseases such as AD and PD. Similar to those of prion-like proteins, pathological aggregates of TDP-43 can be transferred from cell-to-cell in a seed-dependent and self-templating manner. Here, we review clinical and experimental studies supporting the prion-like spreading of misfolded TDP-43 and discuss the molecular mechanisms underlying the propagation of these pathological aggregated proteins. The idea that misfolded TDP-43 spreads in a prion-like manner between cells may guide novel therapeutic strategies for TDP-43-associated neurodegenerative diseases.