bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYFRA 21-1 in patients with suspected cancer: evaluation of an optimal cutoff to assess the diagnostic efficacy and prognostic value
Authors: Garcia-Valdecasas Gayo Sonsoles , Ruiz-Alvarez Maria Jesus , Gonzalez-Gay Daniel , Ramos-Corral Raquel , Marquez-Lietor Eva , Del Amo Nazaret , Plata Maria del Carmen , Guillén-Santos Raquel , Arribas Ignacio , Cava-Valenciano Fernando 
Published: October 2020

Abstract

Objectives
Chosen cutoff for cytokeratin 19 fragment antigen (CYFRA 21-1) as a tumor biomarker considerably influences its diagnostic and prognostic usefulness. The aim of the present study is to determine an optimal cutoff value for diagnostic validity of CYFRA 21-1 by Lumipulse
® technology in patients with suspected cancer and also to determine if CYFRA 21-1 levels provide prognostic value.

Methods
A consecutive 284 patients suggestive of malignant disease from six hospitals of Madrid were enrolled in a retrospective design. Optimal CYFRA 21-1 cutoff value was obtained by receiver operating characteristic curve and Youden test. The diagnostic validity was evaluated according to sensitivity, specificity, predictive values and likelihood ratios. The prognostic value of CYFRA 21-1 was checked using multiple logistic regression. Thirty-two diagnostic cancers were confirmed.

Results
The most optimal cutoff was 3.15 ng/mL. This cutoff showed a better specificity 93.63% (95% confidence interval [CI], 89.66–96.16), positive predictive value 60.98% (95% CI, 44.54–75.38) and positive likelihood ratio 12.65 (95% CI, 7.64–20.95) than the cutoff recommended by Fujirebio® (1.8 ng/mL) (specificity: 73.71% [95% CI, 67.72–78.95], positive predictive value: 29.79% [95% CI, 21.02–40.23] and positive likelihood ratio 3.43 [95% CI, 2.71–4.35]), improving the current diagnostic accuracy. In multivariate analysis, elevated levels of CYFRA 21-1 (>3.15 ng/mL) was confirmed as an unfavorable prognostic factor.

Conclusions
The best cutoff for CYFRA 21-1 obtained was 3.15 ng/mL in patients with suspected cancer. This new cutoff decreases the false positive rate and improves the diagnostic efficacy of CYFRA 21-1 as a tumor marker as well as its association with death events.
Jerusalem Mamluk Regional Building Style as Demonstrated at Maqām al-Nabī Mūsā
Authors: Daʿadli Tawfiq 
Published: October 2020

Abstract
Maqām al-Nabī Mūsā, situated just off the route connecting Jerusalem to Jericho and to Amman further to the east, was a meeting place for thousands of pilgrims that gathered around the shrine during the mawsim (festival). Sultans, clerks, muftis, and wealthy families, who sought the saint’s blessing, put efforts into building facilities for those pilgrims. The earliest products of those donations, still identifiable on the ground, are the mausoleum built by the order of Sultan Baybars (r. 1260–1277) in the early days of the Mamluk era and the manāra (minaret) and the riwāq (open arcade) added by the order of Sultan al-Ashraf Qāytbāy (r. 1468–1496) toward the end of that era. Both building phases bear the imprint of local masons who were active in building Mamluk Jerusalem. Those masons developed their own regional style that differed from that of their counterparts in major Mamluk centers like Damascus and Cairo. A concomitant theme in this article is thus regional styles in architecture.
Some Remarks on Ibn Taymiyyaʼs Acquaintance with Imāmī Shīʿism in light of his Minhāj al-sunna al-nabawiyya
Authors: Vilozny Roy 
Published: October 2020

Abstract

Minhāj al-sunna al-nabawiyya fī naqḍ kalām al-shīʿa al-qadariyya is Ibn Taymiyyaʼs (d. 728/1328) famed voluminous response to Minhāj al-karāma fī maʿrifat al-imāma, a significantly shorter treatise by his Imāmī contemporary, al-ʿAllāma al-Ḥillī (d. 726/1325). Focusing on parts of Minhāj al-sunna in which Ibn Taymiyyaʼs perception of Imāmī Shīʿism comes to the fore, this article sets out to evaluate to what extent his criticism of this manifestation of Islam was founded. Despite the obvious polemical nature of this work, I argue that the juxtaposition of Ibn Taymiyyaʼs portrayal of Imāmī Shīʿism in Minhāj al-sunna with both the information in Imāmī Shīʿī sources until his time and current academic research on Shīʿism reveals that he had a comprehensive acquaintance with a variety of Shīʿī tenets and historical developments. This observation is particularly interesting and important in view of al-Ḥillīʼs alleged dismissive reaction to Ibn Taymiyyaʼs counterwork and the general contemptuous attitude toward Minhāj al-sunna in Imāmī scholarly circles.
Buffered vector error-correction models: an application to the U.S. Treasury bond rates
Authors: Lu Renjie , Yu Philip L. H. 
Published: October 2020

Abstract
This paper extends the buffered autoregressive model to the buffered vector error-correction model (VECM). Least squares estimation and a reduced-rank estimation are discussed, and the consistency of the estimators on the delay parameter and threshold parameters is derived. We also propose a supWald test for the presence of buffer-type threshold effect. Under the null hypothesis of no threshold, the supWald test statistic converges to a function of Gaussian process. A bootstrap method is proposed to obtain the p-value for the supWald test. We investigate the effectiveness of our methods by simulation studies. We apply our model to study the monthly Federal bond rates of United States. We find the evidences of buffering regimes and the asymmetric error-correction effect.
Severe early onset obesity and hypopituitarism in a child with a novel SIM1 gene mutation
Authors: Gonsalves Rob , Aleck Kirk , Newbern Dorothee , Shaibi Gabriel , Kapadia Chirag , Oatman Oliver 
Published: October 2020

Summary
Single-minded homolog 1 (SIM1) is a transcription factor that plays a role in the development of both the hypothalamus and pituitary. SIM1 gene mutations are known to cause obesity in humans, and chromosomal deletions encompassing SIM1 and other genes necessary for pituitary development can cause a Prader–Willi-like syndrome with obesity and hypopituitarism. There have been no reported cases of hypopituitarism linked to a single SIM1 mutation. A 21-month-old male presented to endocrinology clinic with excessive weight gain and severe obesity. History was also notable for excessive drinking and urination. Endocrine workup revealed central hypothyroidism, partial diabetes insipidus, and central adrenal insufficiency. Genetic evaluation revealed a novel mutation in the SIM1 gene. No other genetic abnormalities to account for his obesity and hypopituitarism were identified. While we cannot definitively state this mutation is pathogenic, it is notable that SIM1 plays a role in the development of all three of the patient’s affected hormone axes. He is now 6 years old and remains on treatment for his pituitary hormone deficiencies and continues to exhibit excessive weight gain despite lifestyle interventions.

Learning points:

Mutations in SIM1 are a well-recognized cause of monogenic human obesity, and there have been case reports of Prader–Willi-like syndrome and hypopituitarism in patients with chromosomal deletions that contain the SIM1 gene.

SIM1 is expressed during the development of the hypothalamus, specifically in neuroendocrine lineages that give rise to the hormones oxytocin, arginine vasopressin, thyrotropin-releasing hormone, corticotropin-releasing hormone, and somatostatin.

Pituitary testing should be considered in patients with severe obesity and a known genetic abnormality affecting the SIM1 gene, particularly in the pediatric population.
Successful medical management of insulinoma with diazoxide for 27 years
Authors: Warren Annabelle M , Topliss Duncan J , Hamblin Peter Shane 
Published: October 2020

Summary
Despite improvements in localisation techniques and surgical advances, some patients with insulinoma will not be cured by surgery or may not be suitable for surgery. Medical management with diazoxide is an option for such cases. This case report details 27 years of successful management of insulinoma using diazoxide. It has been effective and safe, with only minor adverse effects.

Learning points:

Long term diazoxide use can be a safe, effective option for insulinoma when it cannot be localised or removed surgically.

Common adverse effects include peripheral oedema, hyperuricaemia, and hirsutism.

68Ga-NOTA-exendin-4 PET/CT scan should be considered for insulinoma localisation when other modalities have been unhelpful.
Determination of organochlorine pesticides in water using GC combined with dispersive solid-phase extraction with single-walled carbon nanotubes
Authors: Sun Peng , Cui Yanhong , Yan Rui , Lian Yongfu 
Published: October 2020

SummaryIn this study, single-walled carbon nanotubes (SWNTs) were used to determine organochlorine pesticides (chlorothalonil and pentachloronitrobenzene) in water using dispersive solid-phase extraction (DSPE), followed by gas chromatography (GC). The optimal adsorption conditions were determined by analyzing the effect of adsorbent dosage, adsorption time, eluent type and volume, and elution time. Under the optimal conditions, a good linearity was obtained at concentrations from 10 to 400 μg L−1 with correlation coefficients ranging from 0.9991 to 0.9986. The limits of detection (LOD) for the two organochlorine pesticides were 0.025 and 0.049 μg L−1, and the limits of quantification (LOQ) were 0.080 and 0.156 μg L−1, respectively. The accuracy of the proposed method was evaluated by measuring the recovery of the spiked samples, which ranged from 82.5% to 110.5% at spiking levels of 0.5–10 μg L−1 with relative standard deviations lower than 5.6% (n = 6). This method was successfully applied to determine the target analytes in canal water, drinking water, and water taken from the inlets and outlets of a wastewater treatment plant. The results demonstrate that the developed method has great potential for determining the two organochlorine pesticides in water samples.
Everything Done with a Pure Intention is Perfect Love. Elements of Discernment of the Spirits in Santa Teresa de Jesús
Authors: De Rycke Filip 
Published: October 2020

Saint Teresa of Ávila intrinsically connects discernment of the spirits with her principal theme of inner prayer. The main constituents of her doctrine of prayer (obedience, humility, charity, detachment) also represent key motifs in her view on discernment. From this perspective, Santa Teresa’s sparse assertions can be integrated into a coherent doctrine on discernment of the spirits, founded in her deep religious experience. Discernment emerges as the core of Christian life and the genuine way in which the Divine Friend gives light for choices that make human persons grow in virtues and in inner freedom.
Duszpasterskie rozeznawanie wspólnotowe: od rozeznawania wspólnotowego do wspólnoty rozeznającej
Authors: Cygański Arkadiusz 
Published: October 2020

Artykuł przedstawia duszpasterski aspekt rozeznawania wspólnotowego inspirowanego zasadami Towarzystwa Jezusowego. Prezentuje podstawowe założenia tego procesu i opisuje jego dialogiczny przebieg. Wskazuje na potrzebę rozeznawania i interpretacji znaków czasów. Rozeznawanie potraktowane jako metoda duszpasterska pomaga uwrażliwić wspólnotę kościelną na wolę Bożą i doświadczenia ludzi, aby dokonać ewangelicznej rewizji życia oraz rozpoznać i zrealizować zamysł Boży wobec wspólnoty.
Sağlık Müdürlüğü Çalışanlarının İş Doyumu ve Tükenmişlik Durumunun Değerlendirilmesi
Authors: ÇAKIR Mustafa , AKALAN Ahmet , YILMAZ Nuray 
Published: October 2020

Bu çalışmada sağlık müdürlüğü çalışanlarının iş
doyumu ve tükenmişlik durumlarının değerlendirilmesi amaçlanmaktadır. Araştırma
tanımlayıcı tipte bir çalışma olup, 219 kişiyle yürütülmüştür. Araştırmada
anket formu kullanılmıştır.
İstatistiksel analizde, tanımlayıcı bulgular kısmında kategorik değişkenler
sayı, yüzde ve sürekli değişkenler ise ortalama ± standart sapma ve ortanca (en
büyük, en küçük değer) ile sunulmuştur. Tüm analizlerde istatistiksel olarak
anlamlılık düzeyi p&lt;0,05 olarak alınmıştır. Çalışmada katılımcıların %63,5’i
kadın; %24,7’si 36-40 yaş grubunda, %22,8’i 41-45 yaş grubunda; %76,3’ü evli;
%61,6’sı üniversite mezunu; %36,2’sinin çalışma süresi 21 yıl ve üzeri;
%21’inin kronik hastalığı olduğu; %30,6’sı sigara içtiğini belirtmiştir.
Çalışanların %30,4’ü işyerine toplu taşıma ile gittiğini; %28,1’i tatile
gitmediğini ve %32,1’i sosyal etkinliklere katılmadığını ifade etmiştir. Araştırmada
katılımcıların tükenmişlik alt boyutundan aldıkları puanlar: duygusal tükenme
puanı ortalaması 11,7±7,7, duyarsızlaşma puanı ortalaması 3,2±3,7, kişisel
başarı puanı ortalaması 20,2±6,2; iş doyumu alt boyutundan aldıkları puanlar:
içsel doyum puan ortalaması 3,6±0,6, dışsal doyum puan ortalaması 3,3±0,8,
genel doyum puan ortalaması 3,5±0,6 olarak saptanmıştır. Duygusal tükenme ile
içsel doyum, dışsal doyum ve genel doyum arasında negatif yönde güçlü bir
ilişki (r:-0,555;-0,526;-0,571) olduğu; duyarsızlaşma ile içsel doyum, dışsal
doyum ve genel doyum arasında negatif yönde orta düzeyde bir ilişki
(r:-0,488;-0,440;-0,489) olduğu; kişisel başarı ile içsel doyum ve genel doyum
arasında pozitif yönde orta düzeyde bir ilişki (r:0,374;0,322), dışsal duyum
ile ise pozitif yönde düşük düzeyde ilişki (r:0,222) olduğu tespit edilmiştir. İş
doyumunun tükenmişlik durumu üzerine önemli etkileri olduğu görülmektedir. İş
doyumunu artırmaya yönelik çalışmaların yapılması önerilmektedir.
Frecuencia y factores asociados al consumo de alcohol, cigarrillo y sustancias psicoactivas, en estudiantes de una Universidad Pública en Colombia
Authors: González-Ospina Alejandra , Rodríguez-Restrepo Andrea , Grajales-Román María Mercedes , Espinosa-Chirivi Yeraldyn , Martínez-Gómez Marta L. , Agudelo-Suárez Andrés A. 
Published: October 2020

Introducción: establecer sistemas de apoyo social a la población universitaria hace necesario su caracterización en salud, estilos de vida y prácticas de riesgo.
Objetivo: determinar la frecuencia y los factores asociados al consumo de sustancias psicoactivas, alcohol y cigarrillo en estudiantes de pregrado de la Facultad de Odontología (Universidad de Antioquia).
Métodos: estudio mixto: (1) estudio descriptivo transversal con 162 participantes (54,3% mujeres) mediante encuesta y análisis uni/bivariado, calculando frecuencias y pruebas Chi cuadrado. (2) Estudio cualitativo mediante 6 grupos focales, análisis narrativo de contenido y triangulación de resultados. Se garantizaron los principios éticos para la investigación en salud.
Resultados: el 30% manifestó embriagarse en los últimos 30 días (mayor proporción en hombres: 40% y p<0,05). La edad mediana de inicio de consumo de alcohol fue de 15,0 años (Rango Intercuartílico RIC 14,0-16,0). La frecuencia de consumo de cigarrillo actual fue 11% y la experiencia (actual/pasada) fue 15%, en ambos casos mayor en hombres. El consumo de sustancias psicoactivas en el último año fue de 22% y la edad mediana de inicio del consumo fue de 16,0 años (RIC 15,0-18,5) (más temprana en hombres). El análisis cualitativo develó categorías relacionadas al consumo: 1) estado anímico, 2) carga académica, 3) utilización del tiempo libre, 4) relaciones interpersonales, 5) condiciones relacionadas con apreciaciones y experiencias previas frente al consumo propio y de personas de su alrededor.
Conclusiones: se encontraron factores asociados al consumo de alcohol, cigarrillo y sustancias psicoactivas que deben considerarse para el diseño de programas de promoción y prevención.
Libropueblo / Herriliburu: El proyecto editorial de Ramiro Pinilla y José Javier Rapha Bilbao (1977-1986)
Authors: Feijoo Morote Javier 
Published: October 2020

Libropueblo/Herriliburu fue una editorial vizcaína fundada por Ramiro Pinilla y José Javier Rapha Bilbao que se desarrolló en los años de la transición española (1977-1986) y que supuso un intento revolucionario por remover los cimientos de la industria editorial. Ambos autores quisieron abanderar la fórmula «del escritor directamente al lector» y propiciar la incardinación de la figura del escritor en la dinámica de los movimientos políticos y sociales de España. El proyecto conllevó la ejecución de todos los pasos de la cadena de producción editorial, así como una política de libros a precio de costo que eliminaba el porcentaje de beneficio para el autor. La realidad cultural y artística de la transición española corre paralela a la génesis, evolución y decadencia final de la editorial, que permite explicar, asimismo, las particularidades de la carrera literaria de Ramiro Pinilla y su posterior evolución como narrador.
https://doi.org/10.17398/2660-7301.41.75
KAJIAN STRATEGIS BISNIS SYARIAH DI INDONESIA
Authors: Nugraha Aryan Eka Prastya , Murniawati Indri , Riyanto Riyanto 
Published: October 2020

Penelitian ini bertujuan untuk mengkaji dengan pendekatan strategis mengenai prospek pengembangan bisnis di Indonesia. Metode penelitian ini yaitu Literature review papers (LRPs) dengan pendekatan empiris yang berarti sintesis dari yang sudah diketahui dalam hal ini data sekunder dari bisnis syariah di Indonesia. Hasil penelitian ini yaitu kajian strategis pada penelitian ini tentunya menjawab beberapa hal yaitu dari aspek formulasi strategi untuk mengembangkan sektor bisnis syariah dengan cara perencanaannya tentu harus mengikuti ketentuan umum, namun tidak meninggalkan prinsip syariah dengan menyediakan pelayanan kepada pelanggan dengan jujur, adil, ihsan dan amanah. Pada implementasi strategi harus bersinergi dengan formulasi yang disusun dengan sinergi pemerintah dan lembaga terkait agar geliat bisnis syariah terus mampu didorong untuk berkembang. Pada tata kelola sistem yang dibangun oleh bisnis perlu adanya proses pemantauan dan pengendalian dari pengelola agar terus sesuai dengan tujuan diciptakannya unit usaha yang pada akhirnya di aspek evaluasi masih memegang teguh prinsip syariah dengan tidak mengorbankan kualitas.
Keywords: strategis, bisnis, syariah
Arte e psicanálise no tratamento da psicose
Authors: Messias Caio Leal 
Published: October 2020

Em 1982 o escritor, psicanalista e dramaturgo belga Henry Bauchau Bauchau dá uma série de conferências sobre Arte e Psicanálise na Universidade Paris VII. Seu livro L’enfant bleu conta a história de Orion, jovem psicótico que, com o auxílio da psicanalista Véronique, descobre na arte uma forma de lidar com seus sintomas. Foi revelado depois que o artista Lionel, um antigo paciente, inspirou o livro. Há proximidades entre o trabalho de Véronique/Baucahu e o da psiquiatra Nise da Silveira no Brasil dos anos 1940. Nos dois casos, teme-se os efeitos iatrogênicos do modelo asilar e da camisa de força química. Busca-se, então, uma forma alternativa de “cura”, um tratamento pela palavra e pela arte, onde importa mais o “cuidado de si”, o fortalecimento do “eu” e o encontrar um lugar no mundo do que a busca de uma “normalidade absoluta”. Este artigo explora proximidades e diferenças entre as duas propostas.
EVALUASI HIDROLIS PADA JARINGAN DISTRIBUSI PDAM TIRTA JATI KABUPATEN CIREBON SISTEM CIBODAS
Authors: Fakhirah Syanocty Putri Farah , Sururi Mohammad Rangga , Sutadian Arief Dhany 
Published: October 2020

Tingginya angka kehilangan air pada Sistem Penyediaan Air Minum (SPAM) menjadi penyebab utama terhambatnya pemenuhan kebutuhan air minum masyarakat. Wilayah studi adalah Sistem Cibodas yang dikelola oleh PDAM Tirta Jati. Wilayah studi tercatat angka kehilangan air tertinggi di sub sistem jaringan distribusi sebesar 62,67% dari debit air yang diproduksi dalam satu bulan. Studi ini memiliki tujuan untuk melakukan evaluasi hidrolis pada jaringan perpipaan Sistem Cibodas dan mengidentifikasi faktor apa saja penyebab kehilangan air. Evaluasi yang dilakukan meliputi evaluasi kuantitas air dari proses produksi, evaluasi pola pemakaian air, evaluasi kehilangan air, dan evaluasi hidrolis jaringan distribusi pada sub sistem SPAM eksisting. Simulasi hidrolis jaringan dilakukan dengan menggunakan software EPANET 2.0 dari Environmental Protection Agency (EPA). Hasil evaluasi menunjukkan penyebab utama tingginya angka air tak berekening di Sistem Cibodas adalah kebocoran pipa dengan persentase kehilangan air sebanyak 17,58% pada jaringan pipa distribusi. Dari evaluasi hidrolis jaringan eksisting terlihat sebanyak 95,86% nodes memiliki tekanan lebih dari 8 atm, 1,06% links memiliki headloss lebih dari 5 m/km, dan sebanyak 74,46% links memiliki kecepatan aliran di bawah kriteria desain. Kata kunci: EPANET 2.0, jaringan distribusi, kebocoran pipa, kehilangan air, ketersediaan air. The high rate of water loss is the main problem in fulfilling the community's need for drinking water. The study area is the Cibodas System which is managed by the PDAM Tirta Jati. In the study area the highest rate of water loss was found in the sub system of distribution network and the percentage of water losses was 62.67% of the water produced in one month. This study aims to evaluate a hydraulic condition of the Cibodas System pipeline and identify the factors that cause water loss. The evaluation were included : (a) quantity of water production; (b) demand patterns; (c) quantity of water losses; and (d) hydraulic simulation of the existing distribution network. The hydraulic simulation process was carried out using EPANET 2.0 from Environmental Protection Agency (EPA). The result shows, the high number of non-revenue water in Cibodas System is mainly caused by pipe leakages with a percentage of 17.58% in distribution pipes. From the hydraulic evaluation of the existing network, it shows that 95.86% nodes had pressures of more than 8 atm, 1.06% links had headloss more than 5 m/ km, and 74.46% links had flow velocities below the design criteria. Keywords: Distribution network, EPANET 2.0, pipe leakage, water losses, water production.