bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Conversation on the Royal Exchange Theatre, Manchester
Authors: Clements Rachel , Frankcom Sarah 
Published: December 2020

Sarah Frankcom worked at the Royal Exchange Theatre in Manchester between 2000 and 2019, and was the venue’s first sole Artistic Director from 2014. In this interview conducted in summer 2019, she discusses her time at the theatre and what she has learned from leading a major cultural organization and working with it. She reflects on a number of her own productions at this institution, including Hamlet, The Skriker, Our Town, and Death of a Salesman, and discusses the way the theatre world has changed since the beginning of her career as she looks forward to being the director of LAMDA. Rachel Clements lectures on theatre at the University of Manchester. She has published on playwrights Caryl Churchill and Martin Crimp, among others, and has edited Methuen student editions of Lucy Prebble’s Enron and Joe Penhall’s Blue/Orange. She is Book Reviews editor of NTQ.
Low-dose steroid-induced bradyarrhythmias and treatment refractory hypokalaemia: a case report
Authors: Ghosh Arindam , Annigeri Saba , Nair Anupama 
Published: December 2020

AbstractCorticosteroid therapy has become an important modality of treatment for diseases in which rapid control of immunoinflammatory processes is required. However, one of the serious, but less known adverse effect of this therapy is cardiac arrhythmias. This includes both tachyarrhythmias and bradyarrhythmias. Corticosteroid use may also be associated with electrolyte imbalances like hypokalaemia by its mineralocorticoid activity. Those side effects are mainly seen with high-dose intravenous methyl-prednisolone or oral pulse dose prednisolone therapy. Here we report our experience in a child with warm idiopathic autoimmune haemolytic anaemia who developed sinus bradyarrhythmias and treatment refractory hypokalaemia during low-dose steroid therapy with reduction in heart rate by 60% of baseline.
Aripiprazole Lauroxil Dosing Regimens: Understanding Dosage Strengths and Injection Intervals
Authors: Sommi Roger W. , Rege Bhaskar , Wehr Angela , Faldu Sejal , Du Yangchun , Weiden Peter J. 
Published: December 2020

AbstractAripiprazole lauroxil (AL) is a long-acting atypical antipsychotic approved for the treatment of schizophrenia in adults. AL has five regimen options that offer three different injection intervals using four different dosage strengths. The relationship between dosage strength (milligram injected), injection interval (time between injection visits), and expected steady-state plasma aripiprazole concentrations may not be readily apparent. This article illustrates the relationship by providing visual scenarios of steady-state plasma aripiprazole concentrations for the five AL regimens. The efficacy of AL was originally demonstrated in a pivotal study of two AL regimens (approved as 441 mg monthly and 882 mg monthly). The three additional regimens (662 mg monthly, 882 mg every 6 weeks, and 1064 mg every 2 months) were approved based on pharmacokinetic bridging studies and population pharmacokinetic models. For this paper, expected steady-state concentrations for each AL regimen were derived from the published population pharmacokinetic models and compared using median values and ranges. The five labeled AL regimens differ in dosage strength and injection interval; however, model-simulated concentrations illustrate that each regimen produces steady-state plasma aripiprazole concentrations within the upper and lower bounds associated with known efficacy for AL 441 mg and 882 mg administered monthly. This visual presentation of the relationship between dosage strength of the AL injection, the interval between successive injections, and steady-state aripiprazole plasma concentrations may demonstrate for clinicians how dosage strength and injection interval can be considered in selecting the AL regimen option that best fits the clinical circumstances of the individual patient.
Stigma and functional neurological disorder: a research agenda targeting the clinical encounter
Authors: MacDuffie Katherine E. , Grubbs Lindsey , Best Tammyjo , LaRoche Suzette , Mildon Bridget , Myers Lorna , Stafford Elizabeth , Rommelfanger Karen S. 
Published: December 2020

AbstractStigma against patients with functional neurological disorder (FND) presents obstacles to diagnosis, treatment, and research. The lack of biomarkers and the potential for symptoms to be misunderstood, invalidated, or dismissed can leave patients, families, and healthcare professionals at a loss. Stigma exacerbates suffering and unmet needs of patients and families, and can result in poor clinical management and prolonged, repetitive use of healthcare resources. Our current understanding of stigma in FND comes from surveys documenting frustration experienced by providers and distressing healthcare interactions experienced by patients. However, little is known about the origins of FND stigma, its prevalence across different healthcare contexts, its impact on patient health outcomes, and optimal methods for reduction. In this paper, we set forth a research agenda directed at better understanding the prevalence and context of stigma, clarifying its impact on patients and providers, and promoting best practices for stigma reduction.
Does body mass index predict response to intravenous ketamine treatment in adults with major depressive and bipolar disorder? Results from the Canadian Rapid Treatment Center of Excellence
Authors: Lipsitz Orly , McIntyre Roger S. , Rodrigues Nelson B. , Lee Yena , Gill Hartej , Subramaniapillai Mehala , Kratiuk Kevin , Nasri Flora , Mansur Rodrigo B. , Rosenblat Joshua D. 
Published: December 2020

AbstractBackgroundHigher body mass index (BMI) has been found to predict greater antidepressant response to intravenous (IV) ketamine treatment. We evaluated the association between BMI and response to repeat-dose IV ketamine in patients with treatment-resistant depression (TRD).MethodsAdults (N = 230) with TRD received four infusions of IV ketamine at a community-based clinic. Changes in symptoms of depression (ie, Quick Inventory for Depressive Symptomatology-Self-Report 16; QIDS-SR16), suicidal ideation (SI; ie, QIDS-SR16 SI item), anxiety (ie, Generalized Anxiety Disorder-7 Scale), anhedonic severity (ie, Snaith–Hamilton Pleasure Scale), and functioning (ie, Sheehan Disability Scale) following infusions were evaluated. Participants were stratified by BMI as normal (18.0-24.9 kg/m2; n = 72), overweight (25-29.9 kg/m2; n = 76), obese I (30-34.9 kg/m2; n = 47), or obese II (≥35.0 kg/m2; n = 35).ResultsSimilar antidepressant effects with repeat-dose ketamine were reported between BMI groups (P = .261). In addition, categorical partial response (P = .149), response (P = .526), and remission (P = .232) rates were similar between the four BMI groups.ConclusionsThe findings are limited by the observational, open-label design of this retrospective analysis. Pretreatment BMI did not predict response to IV ketamine, which was effective regardless of BMI.
Treason and Loyalty to the Royal Court: The Kan Narrative in Nineteenth- and Early-Twentieth-Century Khmer Chronicle Manuscripts
Authors: THUN THEARA 
Published: December 2020

AbstractThe Kan narrative presents a series of events that are believed, by many Cambodians today including top leaders, to be the historical contestation for kingship between a commoner named Kan and members of the royal family during the early sixteenth century. Discussing the contents, the formats, the epistemology, and key figures bound up in the Kan narrative, this article provides insights on its contextual origins and reception as well as the texts that recount it. Rather than a proven historical episode, the narrative was effectively re-constructed by two groups of chronicle writers during the early 1900s in order to promote ideas about ‘treason’ and ‘loyalty’ to the throne. Uncovering the contextual origins and reception of the narrative not only allows us to understand the process whereby a long-held body of local scholarship lying outside the scholarly practice of ‘history’ in the present-day sense was used to shape collective knowledge, but also to see its profound impact on colonial and post-independence collective memory and culture.
A SPHERICAL VERSION OF THE KOWALSKI–SŁODKOWSKI THEOREM AND ITS APPLICATIONS
Authors: OI SHIHO 
Published: December 2020

AbstractLi et al. [‘Weak 2-local isometries on uniform algebras and Lipschitz algebras’, Publ. Mat.63 (2019), 241–264] generalized the Kowalski–Słodkowski theorem by establishing the following spherical variant: let A be a unital complex Banach algebra and let

$\Delta : A \to \mathbb {C}$
be a mapping satisfying the following properties: (a)
$\Delta $
is 1-homogeneous (that is,

$\Delta (\lambda x)=\lambda \Delta (x)$
for all

$x \in A$
,

$\lambda \in \mathbb C$
);
(b)
$\Delta (x)-\Delta (y) \in \mathbb {T}\sigma (x-y), \quad x,y \in A$
.
Then

$\Delta $
is linear and there exists

$\lambda _{0} \in \mathbb {T}$
such that

$\lambda _{0}\Delta $
is multiplicative. In this note we prove that if (a) is relaxed to

$\Delta (0)=0$
, then

$\Delta $
is complex-linear or conjugate-linear and

$\overline {\Delta (\mathbf {1})}\Delta $
is multiplicative. We extend the Kowalski–Słodkowski theorem as a conclusion. As a corollary, we prove that every 2-local map in the set of all surjective isometries (without assuming linearity) on a certain function space is in fact a surjective isometry. This gives an affirmative answer to a problem on 2-local isometries posed by Molnár [‘On 2-local *-automorphisms and 2-local isometries of B(H)', J. Math. Anal. Appl.479(1) (2019), 569–580] and also in a private communication between Molnár and O. Hatori, 2018.
European Forum for Primary Care: Position Paper for Primary Care Mental Health
Authors: Smit Dineke , Hill Lisa , Walton Ian , Kendall Sally , de Lepeleire Jan 
Published: December 2020

Abstract
There is a need for a paradigm shift across mental health in primary care to improve the lives of millions of Europeans. To contribute to this paradigm shift, the European Forum for Primary Care (EFPC-MH) working group for Mental Health, produced a Position Paper for Primary Care Mental Health outlining 14 themes that needed prioritizing. These themes were developed and discussed interactively during the EFPC conferences between 2012 and 2019. The Position Paper on Mental Health gives direction to the necessary improvements over the next ten years. The themes vary from preferable healthcare model to the social determinants highlighting issues such as inequalities. The Statement of Mental Health in Primary Care will be established in cooperation with fellow organizations.
Empowering families facing end-stage nonmalignant chronic diseases with a holistic, transdisciplinary, community-based intervention: 3 months outcome of the Life Rainbow Program
Authors: Law Man-Chi , Lau Bobo Hi-Po , Kwok Anna Y. Y. , Lee Judy S. H. , Lui Rain N. Y. , Liu K. H. , Leung Pamela P. Y. , Chan Cecilia L. W. 
Published: December 2020

AbstractObjectivesFamilies facing end-stage nonmalignant chronic diseases (NMCDs) are presented with similar symptom burdens and need for psycho-social–spiritual support as their counterparts with advanced cancers. However, NMCD patients tend to face more variable disease trajectories, and thus may require different anticipatory supports, delivered in familiar environments. The Life Rainbow Programme (LRP) provides holistic, transdisciplinary, community-based end-of-life care for patients with NMCDs and their caregivers. This paper reports on the 3-month outcomes using a single-group, pre–post comparison.MethodPatients with end-stage NMCDs were screened for eligibility by a medical team before being referred to the LRP. Patients were assessed at baseline (T0), 1 month (T1), and 3 months (T2) using the Integrated Palliative Outcome Scale (IPOS). Their hospital use in the previous month was also measured by presentations at accident and emergency services, admissions to intensive care units, and number of hospital bed-days. Caregivers were assessed at T0 and T2 using the Chinese version of the Modified Caregiver Strain Index, and self-reported health, psychological, spiritual, and overall well-being. Over-time changes in outcomes for patients, and caregivers, were tested using paired-samplet-tests, Wilcoxon-signed rank tests, and chi-square tests.ResultsSeventy-four patients and 36 caregivers participated in this research study. Patients reported significant improvements in all IPOS domains at both 1 and 3 months [ranging from Cohen'sd= 0.495 (nausea) to 1.793 (depression and information needs fulfilled)]. Average hospital bed-days in the previous month fell from 3.50 to 1.68, comparing baseline and 1 month (p< 0.05). At 3 months, caregiver strain was significantly reduced (r= 0.332), while spiritual well-being was enhanced (r= 0.333).SignificanceAfter receiving 3 month's LRP services, patients with end-stage NMCDs and their caregivers experienced significant improvements in the quality of life and well-being, and their hospital bed-days were reduced.
Save Our Senior Noncitizens: Extending Old Age Assistance to Immigrants in the United States, 1935–71
Authors: Fox Cybelle 
Published: December 2020

AbstractWhen do states grant social rights to noncitizens? I explore this question by examining the extension of Old Age Assistance (OAA) to noncitizens after the passage of the 1935 Social Security Act. While the act contained no alienage-based restrictions, states were permitted to bar noncitizens from means-tested programs. In 1939, 31 states had alienage restrictions for OAA. By 1971, when the Supreme Court declared state-level alienage restrictions unconstitutional, only eight states still did. States with more Mexicans and Asians were slower to repeal restriction, however. Using in-depth case studies of New York, California, and Texas, I demonstrate the importance of federal and state institutional arrangements and immigrant political power for the extension of social rights to noncitizens. I also show that to secure access to OAA, immigrant advocates adapted their strategies to match the institutional and political context.
Remembering John C. Loehlin: ‘Our Field Has Lost a Lion’/Twin Research Reviews: Cognitive Skills and Social Mobility, Risk of Arachnoid Hemorrhage, Heritability of Dental Traits, and Twin-to-Twin Transfusion Syndrome/Media Reports: Identical Twins With Different Health Histories, Twins Born 97 Days Apart, Retiring Twin Tennis Players,TikTokTwins and Twin Reality Stars
Authors: Segal Nancy L. 
Published: December 2020

AbstractJohn C. Loehlin, professor of psychology at the University of Texas, at Austin, passed away on August 9, 2020. John was 94 years of age. He will be remembered for his seminal contributions that have furthered the field of twin research in so many ways. An overview of his career is presented, with fond memories from his son and several colleagues. This tribute is followed by reviews of twin research on cognitive skills and social mobility, risk of subarachnoid hemorrhage, heritability of selected dental traits and twin-to-twin transfusion syndrome. Finally, twin-related topics of human interest include identical twins with different health histories, twins born 97 days apart, retiring twin tennis players,TikToktwins and twin reality stars.
Variation and Reactivity of Organic Matter in the Surface Sediments of the Changjiang Estuary and Its Adjacent East China Sea
Authors: Chen Yan , Hu Chun , Yang Gui‐Peng , Gao Xian‐Chi , Zhou Li‐Min 
Published: December 2020

AbstractThe Changjiang Estuary and its adjacent sea make up a highly dynamic ecosystem where the processes influencing the sources and degradation of organic matter (OM) in sediments are still not well understood. In this study, we analyzed the total organic carbon (TOC), total nitrogen (TN), stable carbon isotope (δ13C), and total hydrolysable amino acids (THAA) to investigate the distribution and degradation of sedimentary organic matter (SOM). TOC and TN contents ranged from 0.13% to 0.93% and 0.03% to 0.15%, respectively, with elevated values occurring in the muddy areas near the estuary. The δ13C of SOM became increasingly enriched from inshore (−23.5‰) to offshore (−20.5‰), and the TOC/TN molar ratios (C/N ratios) decreased from 8.16 to 5.84, indicating increasing contributions of marine OM. As the labile fraction of bulk OM, THAA concentrations ranged from 1.36 to 11.76 μmol/g and the distribution of THAA was influenced by terrestrial inputs along with the complex hydrography. The δ13C values and C/N ratios indicated that the SOM in the study area was mainly from marine and terrestrial origins (soil derived). The relatively low degradation index (DI) of SOM (mean: −0.57 ± 0.36) indicated that the OM had already undergone extensive degradation. Consistent with previous findings, our results indicated that the degraded OM was adsorbed by fine‐grained particles and selectively transported southward along the coast. The fresh SOM in the sandy area was mainly from in situ production. Additionally, diatoms appeared to be the primary source of the fresh OM buried in the sediments of the study area.
Does Satellite Chlorophyll‐a Respond to Southernmost Patagonian Dust? A Multi‐year, Event‐Based Approach
Authors: Cosentino N. J. , Ruiz‐Etcheverry L. A. , Bia G. L. , Simonella L. E. , Coppo R. , Torre G. , Saraceno M. , Tur V. M. , Gaiero D. M. 
Published: December 2020

AbstractMineral aerosols may affect global climate indirectly by enhancing net primary productivity (NPP) upon deposition to the oceans and associated atmosphere‐to‐ocean CO2 flux. This mechanism is hypothesized to have contributed significantly to the last interglacial‐to‐glacial climatic transition. However, the dust‐NPP connection remains contentious for the present‐day climate system. We analyze the impact of southernmost Patagonian dust emissions on southwestern Atlantic Ocean continental shelf and proximal open ocean satellite chlorophyll‐a concentration. We use the first decadal time series of surface dust mass flux in southern Patagonia, along with in situ visibility data, to model dust emission, transport, and deposition to the ocean. We then perform a dust event‐based analysis of chlorophyll‐a time series, using a novel approach by which time series are corrected for post‐depositional particle advection due to ocean currents. Finally, we performed chemical analysis of iron in dust samples, a key micronutrient limiting phytoplankton biomass in high‐nutrient, low‐chlorophyll oceans such as offshore of the 200‐m isobath off Patagonia. We find no compelling evidence for an influence of dust as an enhancer of phytoplankton biomass either on shelf or proximal open ocean waters of the southwestern Atlantic Ocean. For open ocean waters this is consistent with a lack of source‐inherited bioavailable iron in dust samples. Future case studies addressing similar questions should concentrate on dust sources with identified high contents of bioavailable iron, particularly in the Southern Hemisphere where atmospheric processing of iron is weak.
Rifting of Collapsed Orogens: Successive Incision of Continental Crust in the Proximal Margin Offshore Norway
Authors: Osmundsen Per Terje , Péron‐Pinvidic Gwenn , Bunkholt Halvor 
Published: December 2020

AbstractStructures related to orogenic “collapse” may provide an important template for reactivation during later rifting. In the proximal rifted margin offshore Norway, the tectono‐sedimentary template related to collapse of the Caledonian mountain belt became widely eroded but inherited metamorphic core complexes and detachment faults evolved further in Late Paleozoic and Earliest Mesozoic time and became associated with very significant crustal thinning. The earliest rifting mode was dominated by structures that mimic the Devonian post‐Caledonian template and comprised a suite of Late Paleozoic to Early Triassic metamorphic core complexes, detachment faults, and supradetachment basins. The deep structure indicates necking of brittle over remnant ductile crust, and we document how the main decoupling level utilized by the earliest rifting structures were cut by a suite of steeper, more deeply incising set of seaward‐ and landward‐dipping Triassic faults. The latter exploited deep shear zones related to the previous intracrustal necking, enabling changes in polarity over short distances. The change from a core complex mode of extension to one involving more deeply incising faults took place prior to deposition of the Late Triassic‐Early Jurassic interrift succession and pre‐dated the main phase of lithospheric‐scale necking associated with Jurassic‐Cretaceous extension. The latter phase of large‐magnitude faulting commenced with reactivation of seaward‐dipping, deeply incised faults inherited from early rifting as well as structures related to the phase of Devonian post‐orogenic transtension. The current study demonstrates that great structural complexity and significant magnitudes of extension may be present in proximal margins, in particular those developed along collapsed orogens.
Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance
Authors: Krook Melanie A. , Reeser Julie W. , Ernst Gabrielle , Barker Hannah , Wilberding Max , Li Gary , Chen Hui-Zi , Roychowdhury Sameek 
Published: December 2020

AbstractFibroblast growth factor receptors (FGFRs) are aberrantly activated through single-nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human cancers, although this frequency increases to 10–30% in urothelial carcinoma and intrahepatic cholangiocarcinoma. We begin this review by highlighting the diversity ofFGFRgenomic alterations identified in human cancers and the current challenges associated with the development of clinical-grade molecular diagnostic tests to accurately detect these alterations in the tissue and blood of patients. The past decade has seen significant advancements in the development of FGFR-targeted therapies, which include selective, non-selective and covalent small-molecule inhibitors, as well as monoclonal antibodies against the receptors. We describe the expanding landscape of anti-FGFR therapies that are being assessed in early phase and randomised controlled clinical trials, such as erdafitinib and pemigatinib, which are approved by the Food and Drug Administration for the treatment ofFGFR3-mutated urothelial carcinoma andFGFR2-fusion cholangiocarcinoma, respectively. However, despite initial sensitivity to FGFR inhibition, acquired drug resistance leading to cancer progression develops in most patients. This phenomenon underscores the need to clearly delineate tumour-intrinsic and tumour-extrinsic mechanisms of resistance to facilitate the development of second-generation FGFR inhibitors and novel treatment strategies beyond progression on targeted therapy.