bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of novel 8-formyl-7-hydroxy-4-methylcoumarin derivatives
Authors: ÇELİK ONAR Hülya , ERDOĞAN Didem 
Published: February 2020

This study was initiated by 7-hydroxy-4-methylcoumarin 1 synthesis according to the Peckmann reaction with resorcinol and ethylacetoacetate. This compound was converted into 8-formyl-7-hydroxy -4-methylcoumarin 2 compound by the Duff reaction. This aldehyde obtained was reacted with 6-amino-1,4-benzodioxane and 2-amino benzamide, which have their specific biological activities, to synthesize the original two novel compounds. While 3 (7-Hydroxy-4-methyl-8-[(2,3-dihidro-1,4-benzodioxin-6-yl)iminomethyl]-2H-1-benzopiran-2-on) is obtained as a coumarin schiff base, ring closure was observed at 4 (2-(2’-Hydoxy-5-methyl coumarin-1-yl)-2,3-dihidro quinazoline-4(1H)-on). Our compounds are thought to exhibit biological activity. Their structures were identified by IR, 1H NMR, 13C NMR , MS analysis.
Determination of Cytotoxic effect and Expression analyses of Apoptotic and Autophagic related genes in Thymoquinone-treated Colon Cancer Cells
Authors: TOKAY Esra 
Published: February 2020

Thymoquinone
(Tq; 2-isopropyl-5-methyl-1,4 benzoquinone) is the main ingredient present in
the volatile oil of Nigella sativa
(black seed). Recently, it has been reported that, Tq was inhibited cell
proliferation of many cancer cell lines including ovarian, lung, breast, osteosarcoma,
pancreatic, fibrosarcoma, lung cancer, squamous cell carcinoma and myeloblastic
leukemias. In this study, the anticancer effect
of Tq was investigated in human Colon Cancer Cells (HT-29) with MTT assay.
Positive control was achieved with 5-fluorouracil (5-FU). Also, the invasion
capability of HT-29 cellls was determined in presence of Tq and 5-FU with
scratch analyses. In addition, the autophagic and apoptotic effect of Tq were
investigated by qRT-PCR method to find out the pathway of anti-proliferative
effect in Tq-treated HT-29 cells. As a result, Tq was inhibited the cell
proliferation of HT-29 cells in time dependent manner, with 118 µM for 24 h and 84 µM for 48 h, respectively. A
concentration of 150 µM of Tq was able to significantly reduced the
invasiveness of HT-29 cells about ̴8
fold compared with not treated cells at 6h. ATG-12, ATG-7 and LC3-II were
significantly downregulated in presence of Tq. Conversaly, the expression of all of the
autophagy genes were downregulated in presence of 5-FU. Moreover, pro-apoptotic
gene Bax was significiantly upregulated nearly 15 fold whereas the expressions
of Bcl-2 and Bcl-XL (pro-survival genes) were decreased in presence of Tq. On
the other hand, in 5-FU treated HT-29 cells, the expression of Bax, Bcl-2 and Bcl-XL genes and
autophagy related genes were significantly downregulated.
Role of boron mineral size on thermal, microstructural and mechanical characteristic of IPP
Authors: SOYKAN Uğur 
Published: February 2020

This study paves to way to investigate the fundamental
characteristics including the crystalline melting temperature, percent crystallinity,
crystal structure, unit cell parameters, crystal size, mechanical behaviour,
ultimate strength, Modulus and impact strength in the IPP based composites
formed by blending of IPP with the varying content levels (5, 10, 15, 20 and
30%) of ulexites having different particle sizes (45 and 75µm). The
characterizations of the prepared IPP
based composites containing ulexite were performed by means of conventional
measurement methods such as Differential Scanning Calorimeter (DSC), X-ray
diffractions and several mechanical tests. The obtained results depicted that
the content and particle size of boron mineral presenting in IPP based
composites had significant effects on the crucial properties of IPP. Namely,
the crystalline melting temperature of IPP increased initially (165.46°C to
168.54°C) when adding 5% of 45µm ulexite into IPP and then, dramatic decrease
was observed with the content increment. The addition of 75µm ulexite into to
IPP matrix led to consistent decreasing of crystalline melting temperatures of
IPP domains. Furthermore, a and b unit cell dimensions of monoclinic
structures initially showed the expansions, but then contracted consistently
with the increasing of ulexite content. The serious decrement in c unit cell
parameter was observed with the increasing of ulexite content for the both
particle sizes.Moreover, the remarkable reinforcements were achieved in the
ultimate strengths, Young's Modulus and impact strength of the IPP based
composites. The maximum improvements in mechanical properties were obtained
with the composites containing 5% of 45µm ulexite and mainly 15% of 75µm
ulexite. These developments presumably were caused from advance in the
alignments and orientations of the IPP chains in the matrix due to presence of
ulexite particles.
KOMUNIKASI VIRTUAL GAME ONLINE DEFENCE OF THE ANCIENT–DOTA 2 PADA KOMUNITAS RAZER GAMING DEPOK VIRTUAL COMMUNICATION IN THE DEFENCE OF THE ANCIENT–DOTA 2 ONLINE GAME AT THE RAZER GAMING DEPOK COMMUNITY
Authors: Teguhta Teguhta , Dunan Amri 
Published: February 2020

Abstract In the era of the industrial revolution 4.0, virtual communication tends to be preferred over face-to-face communication among teenagers. Virtual communication is usually carried out in virtual communities that share a hobby like online game players.interviews and observations method were used on data collection. Data presentation, categorization, and data reduction are carried out at the data analysis stage. Data triangulation is done to conclude. The findings of this study are the virtual communication all channels patterns apply in Depok Razer Gaming Community. Virtual communication often used about the selection of strategies in the online game Dota 2.Keywords: virtual communication, online game Abstrak Kalangan remaja cenderung lebih menyukai komunikasi virtual dibandingkan dengan komunikasi tatap muka pada era revolusi industri 4.0 saat ini. Komunitas virtual yang memiliki kesamaan hobi seperti para pemain game online biasanya melakukan komunikasi virtual. Tujuan penelitian ini untuk mengidentifikasi pola komunikasi virtual dalam game online Defence of the Ancient–Dota 2 dalam Komunitas Razer Gaming Depok. Penelitian ini menggunakan. pendekatan deskriptif kualitatif . Pengumpulan data di lapangan menggunakan metode wawancara dan pengamatan. Pada tahapan analisis data peneliti melakukan penyajian data, pengkategorisasian, dan reduksi data. Peneliti melakukan triangulasi data yang ada untuk penarikan kesimpulan. Penelitian ini menemukan bahwa pola komunikasi virtual yang berlangsung di Komunitas Razer Gaming Depok adalah pola komunikasi semua saluran (all channel). Komunikasi virtual sering membahas tentang pemilihan strategi dalam game online Dota 2. Kata Kunci : komunikasi virtual, game online
Prolapso de trompa uterina: reporte de casos y revisión de la literatura
Authors: Niño-Hernández Lucía Mercedes , Redondo-Bermúdez César , Redondo de Oro Katherine , Marrugo-Grace Olivia , Arteta-Acosta Cindy , Alcalá-Cerra Gabriel 
Published: February 2020

Objetivo: el prolapso de la trompa uterina constituye una complicación quirúrgica poco frecuente y habitualmente ocurre de manera secundaria a la histerectomía vaginal. Dicha patología constituye un reto diagnóstico dado el espectro de lesiones benignas y malignas a nivel del cuello uterino. El presente reporte de casos tiene como objetivo revisar la literatura respecto a la etiología, el diagnóstico y el tratamiento de la entidad.Materiales y métodos: se presentan tres casos de prolapso de trompa uterina, así como una revisión de la literatura, a través de una búsqueda electrónica en las bases de datos Medline vía PubMed, Hinari, SciELO y EMBASE, para recopilar información publicada, tanto en inglés como en español, de los últimos 5 años.Conclusión: el prolapso de trompa uterina poshisterectomía, ya sea vaginal o abdominal, es una complicación quirúrgica anómala. El diagnóstico definitivo se realiza por medio del estudio histopatológico, al evidenciar tejido tubárico asociado a un infiltrado inflamatorio. Para su tratamiento, diferentes técnicas quirúrgicas han sido propuestas con el objetivo de resecar, ya sea parcial o totalmente, la trompa prolapsada con reparo de la apertura vaginal.
Software complex for assessment and rehabilitation of motor disorders in patients with ischemic stroke
Authors: Tolmachev I. V. , Alifirova V. M. , Kаzakov S. D. , Koroleva E. S. 
Published: February 2020

Objective. Development of a specialized software complex that creates a controlled virtual environment as well as to capture and calculate the movement data in the process of rehabilitation.Materials and methods. To evaluate the impact of visual stimuli created using the augmented reality system on the motor function, a software was developed that visualizes data via augmented reality glasses and processes data obtained from motion capture sensors. The study was conducted at the Department of Neurology and Neurosurgery and the Department of Medical and Biological Cybernetics of Siberian State Medical University in 2018–2019. The sample included 59 patients with acute ischemic cerebral stroke in the middle cerebral artery. The course of motor rehabilitation using augmented reality technology was ten days. The duration of one training session was 60 minutes.Results. Motor neurorehabilitation of patients with paresis of the upper extremities using augmented reality makes it possible to improve motor skills. Analysis of the accuracy of movements showed a significant increase in the value of the spectral criterion with an increase in the number of trainings, which indicates a decrease in the number of unnecessary movements during the main task. A significant increase in the number of completed movements with each subsequent training was revealed. This indicates a rise in the speed of the task over the course of rehabilitation, as well as reduction of the rest period between the attempts performed during one training session.Conclusion. The developed specialized software recreates a controlled virtual environment with the ability to register the parameters of human movement. The method was used for rehabilitation of motor disorders in patients with ischemic stroke of the brain and paresis of the upper extremities. The results of the study revealed a significant increase in the accuracy of movements, and a rise in endurance, which indicates the effectiveness of the approach in motor neurorehabilitation.
Incidence rate of anxiety and personality disorders and their interrelationship in senior-year students of the medical university
Authors: Ukraintsev I. I. , Schastnyy E. D. , Bokhan N. A. 
Published: February 2020

Objective: to study the incidence rate of personality and anxiety disorders and their interrelationship in seniors of the medical university.Materials and methods. The screening study for detection of personality and anxiety disorders using the Generalized Anxiety Disorder-7 (GAD-7) and Standardized Assessment of Personality – Abbreviated Scale (SAPAS) scales included 104 senior-year students of the medical university. In the studied sample, males (n = 46; 44.2%) and females (n = 58; 55.8%) (p < 0.05) were equally represented, the average age of men was 23 (23; 25) years, women – 23 (23; 23) years. Statistical processing was performed using the Pearson’s χ2 test, Mann–Whitney U test to compare independent samples, and the Spearman correlation analysis (r) with a preliminary estimate of the normal distribution.Results. The data on the statistically significant differences in the level of anxiety and personality disorders depending on gender and age were obtained. Using the GAD-7 scale, the presence of moderate and average level of anxiety in male students was revealed in 26.1%, in female students – in 48.3% (ð = 0.001). The use of SAPAS scale revealed statistically insignificant differences in the studied groups: in males – 4 (4; 6) points, in the group of female students – 4 (3; 5) points (ð = 0.2).Conclusion. A logistic regression model was obtained that predicted the highest likelihood of development of anxiety disorders.
Amino acids and acylcarnitines as potential metabolomic markers of schizophrenia: new approaches to diagnostics and therapy
Authors: Mednova I. A. , Serebrov V. Yu. , Baikov A. N. , Bohan N. A. , Ivanova S. A. 
Published: February 2020

Background. Schizophrenia is a socially significant mental illness with insufficiently studied etiology and pathogenesis. A number of hypotheses of schizophrenia pathogenesis (dopamine, glutamate, kinurenin and serotonin hypotheses) bring together the fact that amino acids are precursors or intermediate metabolic products of these metabolites. Amino acids and their metabolites play an important role as significant substrates and regulators in many metabolic pathways.The aim of this review is to analyze the literature data on the studies of amino acids and acylcarnitines in patients with schizophrenia.Methods. A literature search was conducted using PubMed databases for articles published in English and covering the period from the first articles on this topic, dated 1977 to April 2019. Combinations of the following keywords were used to search for “schizophrenia”, “antipsychotics” and “amino acids”, “acylcarnitines”, “metabolomics”.Results. The review summarizes the data on the content of amino acids and acylcarnitines in the peripheral blood of schizophrenia patients and their dynamics in the course of pharmacotherapy with antipsychotic drugs. The potential of determining amino acids as biomarkers of therapeutic response and side effects, as well as their use in the treatment of patients with schizophrenia, are considered.Conclusion. Further investigation of the spectrum of amino acids and their metabolites with the using of mass spectrometric methods of metabolic analysis can lead to the discovery of new therapeutic targets and strategies, assess their role in the pathophysiology of schizophrenia, identify mechanisms that ensure the development of antipsychotic antipsychotics, and drug-induced side effects antipsychotics, in particular, metabolic syndrome.
Educação & Formação Journal: balance of scientific production (2016-2018)
Authors: Fialho Lia Machado Fiuza , Sousa Francisca Genifer Andrade de , Nascimento Karla Angélica Silva do 
Published: February 2020

The objective is to analyze the scientific production published by the Educação & Formação Journal between 2016-2018, identifying the main educational thematic categories discussed in this triennium. State of art research was used, methodologically supported by categorical analysis of the disseminated articles, considering their title, keywords and abstracts. 101 products were identified, which culminated in five main thematic categories: “Teacher Training”, “History of Education”, “Educational Policy”, “Inclusive Education” and “Technology and Digital Culture”. These were mostly discussed through qualitative research, such as literature review and case study, using literature review, interviews and document analysis. The discussions pointed out that the literature published by Educação & Formação focuses on the subfield teacher training, as proposed by the focus and scope of the journal, making it a reference in this field. The published literature highlights the qualification of teachers of basic education and the gaps regarding the qualification of higher education teachers.
Development and external validation of an online clinical prediction model for augmented renal clearance in adult mixed critically ill patients: the ARC predictor
Authors: Gijsen Matthias , Huang Chao-yuan , Flechet Marine , Daele Ruth Van , Declercq Peter , Debaveye Yves , Meersseman Philippe , Meyfroidt Geert , Wauters Joost , Spriet Isabel 
Published: February 2020

Abstract
Background

Augmented renal clearance (ARC) might lead to subtherapeutic plasma levels of drugs with predominant renal clearance. Early identification of ARC remains challenging for the intensive care unit (ICU) physician. We developed and validated the ARC predictor, a clinical prediction model for ARC on the next day during ICU stay, and made it available via an online calculator. Its predictive performance was compared with that of two existing models for ARC.

Methods

A large multicenter database including medical, surgical and cardiac surgery ICU patients (n = 33258 ICU days) from three Belgian tertiary care academic hospitals was used for the development of the prediction model. Development was based on clinical information available during ICU stay. We assessed performance by measuring discrimination, calibration and net benefit. The final model was externally validated (n = 10259 ICU days) in a single-center population.

Results

ARC was found on 19.6% of all ICU days in the development cohort. Six clinical variables were retained in the ARC predictor: day from ICU admission, age, sex, serum creatinine, trauma and cardiac surgery. External validation confirmed good performance with an area under the curve of 0.88 (95% CI 0.87 – 0.88), and a sensitivity and specificity of 84.1 (95% CI 82.5 – 85.7) and 76.3 (95% CI 75.4 – 77.2) at the default threshold probability of 0.2, respectively.

Conclusion

ARC on the next day can be predicted with good performance during ICU stay, using routinely collected clinical information that is readily available at bedside. The ARC predictor is available at www.arcpredictor.com .
Increased Expression Together with the Gene Regulation Network of NEIL3 Predicts Poor Prognosis and Correlates with Immune Infiltrates in Hepatocellular Carcinoma
Authors: Hu Bo , Yang Xiao-Bo , Sang Xinting 
Published: February 2020

Abstract
Background: Abnormal Nei endonuclease VIII-like 3 (NEIL3)expression is associated with carcinogenesis.
Methods: We used sequencing data from the Cancer Genome Atlas database, analyzed NEIL3 expression, gene regulation networks and the correlation with immune infiltrates in hepatocellular carcinoma (HCC). Clinicopathologic characteristics associated with overall survival in TCGA patients using Cox regression and the Kaplan-Meier method. Gene Set Enrichment Analysis was performed using TCGA data set. LinkedOmics was used to identify differential gene expression with NEIL3 and to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. Gene enrichment analysis examined target networks of kinases and transcription factors.Correlations between NEIL3 expression and cancer immune infiltrates and immune gene markers were analyzed by TIMER and GEPIA.
Results: We found that overexpressed NEIL3 predicted poor prognosis. Functional network analysis suggested that NEIL3 regulates the DNA replication and cell cycle signaling via pathways involving several cancer-related kinases and E2F Transcription Factor 1.NEIL3 was also found to be associated with the infiltration of several immune cells.
Conclusions: Our results demonstrate that data mining efficiently reveals information about NEIL3 expression, potential regulatory networks and the relationship with immune infiltration in HCC, laying a foundation for further study of the role of NEIL3 in carcinogenesis.
Plasma APRIL as a Potential Biomarker in the Diagnosis of Obstructive Sleep Apnea
Authors: Wen Wan-Wan , Sun Hai-Li , Yang Yun-Xiao , Jia Yi-Fan , Huang Meng-Ling , Du Yun-Hui , Qin Yan-Wen , Fang Fang , Zhang Ming , Wei Yong-Xiang 
Published: February 2020

Abstract
Background: Obstructive sleep apnea (OSA) is the most common type of sleep breathing disorder and is characterized by chronic intermittent hypoxia, which could cause inflammation and NF-KB-dependent inflammatory pathways activation. Circulating APRIL might play an important role in promoting inflammation and NF-KB-dependent inflammatory pathways activation. We explored the role of APRIL as a potential mechanism of inflammation in OSA patients. Methods: After detailed sleep evaluated, venous blood and demographic data were collected from 155 subjects with varying severity of OSA and 52 control subjects. Plasma levels of APRIL were measured by human Magnetic Luminex assay. Results: Plasma APRIL levels were significantly higher in OSA subjects compared with control subjects. Categorization of the OSA subjects into mild, moderate, and severe OSA subgroups showed that plasma levels of APRIL increased with severity. After adjusting confounding factors, found that increased plasma APRIL levels were conferred a higher odds ratio (OR) of OSA. Moreover, plasma APRIL levels were positively associated with the apnea-hypopnea index. Furthermore, plasma APRIL showed higher discriminatory accuracy in predicting the presence of OSA. Conclusions:Plasma APRIL levels were significantly associated with the occurrence of OSA and its severity. APRIL could be a plasma biomarker with a positive diagnostic value for inflammation and NF-KB–dependent inflammatory pathways activation in subjects with OSA.
Cemented versus uncemented arthroplasty for the management of femoral neck fractures in the elderly
Authors: Li Lang , Yang Xiaodong , Jiang Jun , Yang Lei , Xing Fei , Tang Xueyang 
Published: February 2020

Abstract
Background Hemiarthroplasty and total hip arthroplasty (TKA) are commonly used to treat unstable femoral neck fractures in older patients. However, there is no consensus on the use of cement during hemiarthroplasty and TKA. Previous reviews on this subject included small number of studies and lacked evidence grading of outcomes. In this study, we aimed to compare the outcomes of cemented and uncemented arthroplasty for the treatment of femoral neck fractures in older patients. Methods A meta-analysis was conducted according to the guidelines of the Cochrane Collaboration using online databases (Pubmed, Cochrane Central Register of Controlled Trials, and Ovid). The quality of the included studies was assessed using the Cochrane Collaboration tool and Newcastle-Ottawa Scale. Prospective cohort studies and randomized controlled trials (RCT) of cemented arthroplasty versus uncemented arthroplasty for treatment of femoral neck fractures were analyzed using Review Manager (version 5.2) software. Results Sixteen studies were included in the meta-analysis. Cemented arthroplasty was found to be superior to uncemented arthroplasty with respect to reoperation rate, complications related to prosthesis, residual pain, and operation time. There were no significant between-group differences with respect to local and general complications, duration of hospital stay, hip function, and mortality. Conclusion Compared with cemented arthroplasty, uncemented arthroplasty was associated with a greater risk of complications related to prosthesis, reoperation rate, residual pain, and longer operation time. However, the results of this meta-analysis should be interpreted cautiously owing to some limitations. Further studies are required to provide more robust evidence.