bluuebunny/crossref_metadata_2025_split huggingface dataset:
The state of artificial intelligence-based FDA-approved medical devices and algorithms: an online database
Authors: Benjamens Stan , Dhunnoo Pranavsingh , Meskó Bertalan 
Published: September 2020

AbstractAt the beginning of the artificial intelligence (AI)/machine learning (ML) era, the expectations are high, and experts foresee that AI/ML shows potential for diagnosing, managing and treating a wide variety of medical conditions. However, the obstacles for implementation of AI/ML in daily clinical practice are numerous, especially regarding the regulation of these technologies. Therefore, we provide an insight into the currently available AI/ML-based medical devices and algorithms that have been approved by the US Food & Drugs Administration (FDA). We aimed to raise awareness of the importance of regulatory bodies, clearly stating whether a medical device is AI/ML based or not. Cross-checking and validating all approvals, we identified 64 AI/ML based, FDA approved medical devices and algorithms. Out of those, only 29 (45%) mentioned any AI/ML-related expressions in the official FDA announcement. The majority (85.9%) was approved by the FDA with a 510(k) clearance, while 8 (12.5%) received de novo pathway clearance and one (1.6%) premarket approval (PMA) clearance. Most of these technologies, notably 30 (46.9%), 16 (25.0%), and 10 (15.6%) were developed for the fields of Radiology, Cardiology and Internal Medicine/General Practice respectively. We have launched the first comprehensive and open access database of strictly AI/ML-based medical technologies that have been approved by the FDA. The database will be constantly updated.
Pre-pro is a fast pre-processor for single-particle cryo-EM by enhancing 2D classification
Authors: Chung Szu-Chi , Lin Hsin-Hung , Niu Po-Yao , Huang Shih-Hsin , Tu I-Ping , Chang Wei-Hau 
Published: September 2020

Abstract2D classification plays a pivotal role in analyzing single particle cryo-electron microscopy images. Here, we introduce a simple and loss-less pre-processor that incorporates a fast dimension-reduction (2SDR) de-noiser to enhance 2D classification. By implementing this 2SDR pre-processor prior to a representative classification algorithm like RELION and ISAC, we compare the performances with and without the pre-processor. Tests on multiple cryo-EM experimental datasets show the pre-processor can make classification faster, improve yield of good particles and increase the number of class-average images to generate better initial models. Testing on the nanodisc-embedded TRPV1 dataset with high heterogeneity using a 3D reconstruction workflow with an initial model from class-average images highlights the pre-processor improves the final resolution to 2.82 Å, close to 0.9 Nyquist. Those findings and analyses suggest the 2SDR pre-processor, of minimal cost, is widely applicable for boosting 2D classification, while its generalization to accommodate neural network de-noisers is envisioned.
Quantification of amyloid fibril polymorphism by nano-morphometry reveals the individuality of filament assembly
Authors: Aubrey Liam D. , Blakeman Ben J. F. , Lutter Liisa , Serpell Christopher J. , Tuite Mick F. , Serpell Louise C. , Xue Wei-Feng 
Published: September 2020

AbstractAmyloid fibrils are highly polymorphic structures formed by many different proteins. They provide biological function but also abnormally accumulate in numerous human diseases. The physicochemical principles of amyloid polymorphism are not understood due to lack of structural insights at the single-fibril level. To identify and classify different fibril polymorphs and to quantify the level of heterogeneity is essential to decipher the precise links between amyloid structures and their functional and disease associated properties such as toxicity, strains, propagation and spreading. Employing gentle, force-distance curve-based AFM, we produce detailed images, from which the 3D reconstruction of individual filaments in heterogeneous amyloid samples is achieved. Distinctive fibril polymorphs are then classified by hierarchical clustering, and sample heterogeneity is objectively quantified. These data demonstrate the polymorphic nature of fibril populations, provide important information regarding the energy landscape of amyloid self-assembly, and offer quantitative insights into the structural basis of polymorphism in amyloid populations.
Silylium ion mediated 2+2 cycloaddition leads to 4+2 Diels-Alder reaction products
Authors: Wang Heng-Ding , Fan Hong-Jun 
Published: September 2020

AbstractThe mechanism of silver(I) and copper(I) catalyzed cycloaddition between 1,2-diazines and siloxy alkynes remains controversial. Here we explore the mechanism of this reaction with density functional theory. Our calculations show that the reaction takes place through a metal (Ag+, Cu+) catalyzed [2+2] cycloaddition pathway and the migration of a silylium ion [triisopropylsilyl ion (TIPS+)] further controls the reconstruction of four-member ring to give the final product. The lower barrier of this silylium ion mediated [2+2] cycloaddition mechanism (SMC) indicates that well-controlled [2+2] cycloaddition can obtain some poorly-accessible IEDDA (inverse-electron demand Diels-Alder reaction) products. Strong interaction of d10metals (Ag+, Cu+) and alkenes activates the high acidity silylium ion (TIPS+) in situ. This п-acid (Ag+, Cu+) and hard acid (TIPS+) exchange scheme will be instructive in silylium ion chemistry. Our calculations not only provide a scheme to design IEDDA catalysts but also imply a concise way to synthesise 1,2-dinitrogen substituted cyclooctatetraenes (1,2-NCOTs).
Therapeutic potential of Liuwei Dihuang pill against KDM7A and Wnt/β-catenin signaling pathway in diabetic nephropathy-related osteoporosis
Authors: Liu Ming Ming , Dong Rui , Hua Zhen , Lv Nan Ning , Ma Yong , Huang Gui Cheng , Cheng Jian , Xu Hai Yan 
Published: September 2020

Abstract
The effects of Liuwei Dihuang pill (LWDH) on diabetic nephropathy-related osteoporosis (DNOP) are unclear. The present study aimed to evaluate the effects of LWDH on KDM7A and Wnt/β-catenin signaling pathway in DNOP rats and the high glucose-induced MC3T3-E1 cells. A DNOP model was prepared by streptozotocin in 9-week-old male Sprague-Dawley (SD) rats to evaluate the effects of LWDH. The cell viability and differentiation capacity of high glucose-induced MC3T3-E1 cells were determined by CCK-8 assay, Alizarin Red staining, and alkaline phosphatase (ALP) staining, respectively. Furthermore, the expressions of KDM7A and Wnt1/β-catenin pathway-related proteins were determined by Western blot analysis. Treatment of DNOP rats with LWDH could significantly ameliorate the general state, degradation of renal function, and renal pathological changes. LWDH decreased the levels of TNF-α, IL-6, IL-8, IL-1β, ALP, and TRAP, and increased the calcium, phosphorus in serum, as well as decreased the level of the calcium and phosphorus in the urine. Besides, LWDH significantly improved bone mineral density (BMD), bone volume (BV), and the bone microstructure of DNOP rats. Moreover, LWDH increased the levels of the elastic modulus, ultimate load, and bending strength in the femurs. In MC3T3-E1 cells, serum-containing LWDH significantly increases in cell viability and osteoblastic differentiation capability. The expression of α-SMA, vimentin, KDM7A, Wnt1 and β-catenin were significantly down-regulated, and the E-cadherin, H3K9-Me2, H3K27-Me2, BMP-4, BMP-7, Runx2, osteocalcin, and Col1a1 were significantly up-regulated with LWDH treatment. The present study shows that LWDH has a therapeutic effect on DNOP, in part, through down-regulation of KDM7A and Wnt/β-catenin pathway.
The Relationship Between Psychological Processes and Indices of Well-Being Among Adults With Hearing Loss
Authors: Whicker John J. , Ong Clarissa W. , Muñoz Karen , Twohig Michael P. 
Published: September 2020

Purpose
The purpose of this study was to explore the role of psychological processes (i.e., internalized shame, self-efficacy, psychological inflexibility) regarding hearing loss in the well-being of adults who have hearing loss.

Method
This study used a cross-sectional survey design. Two hundred sixty-four surveys were submitted for analysis. Data were collected using a survey posted to online social media support, in audiology clinics across the country, and through national organizations supporting individuals who have hearing loss. Regressions were used to determine whether internalized shame, self-efficacy, or psychological inflexibility held any predictive value over subjects' well-being.

Results
Shame, self-efficacy, and psychological inflexibility significantly predicted different aspects of well-being.

Conclusion
Audiologists should consider the role of internalized thoughts and emotions regarding patients' hearing loss on how patients understand and manage their hearing health.
Formation of a tiny flux rope in the center of an active region driven by magnetic flux emergence, convergence, and cancellation
Authors: Zheng Ruisheng , Chen Yao , Wang Bing , Song Hongqiang , Cao Wenda 
Published: September 2020

Aims. Flux ropes are generally believed to be core structures of solar eruptions that are significant for the space weather, but their formation mechanism remains intensely debated. We report on the formation of a tiny flux rope beneath clusters of active region loops on 2018 August 24.
Methods. Combining the high-quality multiwavelength observations from multiple instruments, we studied the event in detail in the photosphere, chromosphere, and corona.
Results. In the source region, the continual emergence of two positive polarities (P1 and P2) that appeared as two pores (A and B) is unambiguous. Interestingly, P2 and Pore B slowly approached P1 and Pore A, implying a magnetic flux convergence. During the emergence and convergence, P1 and P2 successively interacted with a minor negative polarity (N3) that emerged, which led to a continuous magnetic flux cancellation. As a result, the overlying loops became much sheared and finally evolved into a tiny twisted flux rope that was evidenced by a transient inverse S-shaped sigmoid, the twisted filament threads with blueshift and redshift signatures, and a hot channel.
Conclusions. All the results show that the formation of the tiny flux rope in the center of the active region was closely associated with the continuous magnetic flux emergence, convergence, and cancellation in the photosphere. Hence, we suggest that the magnetic flux emergence, convergence, and cancellation are crucial for the formation of the tiny flux rope.
Alkohol zur Vermeidung alkoholbezogener Störungen bei chirurgischen Patienten
Authors: Stuppe Markus , Facklam Jochen , Schumacher Detlef 
Published: September 2020

ZusammenfassungEin erheblicher Teil der Patienten mit einer alkoholbezogenen Störung verschweigt oder bagatellisiert aus Scham bei einer Aufnahme ins Krankenhaus einen erhöhten Alkoholkonsum. Wenn ein Patient explizit nicht vom Alkohol entziehen will und ohne Ersatz oder fortgesetzter Alkoholzufuhr ein Alkoholentzugssyndrom droht – kann dann neben der üblichen medikamentösen Behandlung der medizinische Einsatz von i. v. und oralem Alkohol sinnvoll sein? Welche Alternativen gibt es? Der Beitrag geht den Fragen in einer Literaturrecherche nach.
Synthetic Approaches to Non-Tropane, Bridged, Azapolycyclic Ring Systems Containing Seven-Membered Carbocycles
Authors: Griffith Daniel R. , Shoemaker Aaron H. 
Published: September 2020

AbstractThis Short Review highlights various synthetic approaches to bridged azabicyclic ring systems containing seven-membered carbocyclic rings. Such ring systems are common to a number of biologically active natural products. The seven-membered ring in such systems is generally formed in one of four ways: 1) cyclization of an acyclic precursor; 2) ring expansion or rearrangement of a different ring size; 3) cycloaddition; and 4) use of a synthetic building block with the seven-membered ring already present. Representative examples of each approach from both total synthesis and methodological studies are discussed, with an emphasis on work publishedin the last twenty years.1	Introduction2	Cyclization Reactions3	Ring Expansions and Rearrangements4	Cycloadditions5	Strategies Involving Seven-Membered Ring Building Blocks6	Conclusion
Challenges in the Transition of Care Process for Patients with Dravet and Lennox–Gastaut Syndromes
Authors: Karakas Cemal , Schultz Rebecca J. , Gavvala Jay R. 
Published: September 2020

AbstractEpileptic encephalopathies such as Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS) present unique challenges in the transition of care not only for the providers but also for the patients and families. Some of these challenges include the complexity of disease process, differences in medication management between children and adults, high incidence of comorbidities such as psychosocial issues, a lack of structured transition process from pediatric to adult care, and the lack of parental knowledge and reluctance to transition to an adult provider. Improving transition readiness and transfer of care are essential to long-term management and continuity of care. Studies show that patients/families who possess transition readiness skills have better health outcomes. Furthermore, participation in a structured transition intervention has been shown to improve transition readiness and utilization of ambulatory care in the adult setting. Reported benefits of implementation of transition planning include increased self-esteem, improved health literacy, fewer emergency room visits, decreased hospitalizations and comorbidities, and fewer school absences. Nevertheless, there is a lack of evidenced-based, family/patient-centered transition model of care. This review's primary goal is to provide an overview of challenges in the transition of care and recommendations for an ideal transition for patients with DS and LGS.
Labor Induction at 39 Weeks Compared with Expectant Management in Low-Risk Parous Women
Authors: Wagner Stephen M. , Sandoval Grecio , Grobman William A. , Bailit Jennifer L. , Wapner Ronald J. , Varner Michael W. , Thorp John M. , Prasad Mona , Tita Alan T. N. , Saade George R. , Sorokin Yoram , Rouse Dwight J. , Tolosa Jorge E. ,   for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network
Published: September 2020

Objective Our objective was to compare outcomes among low-risk parous women who underwent elective labor induction at 39 weeks versus expectant management.
Study Design This is a secondary analysis of an observational cohort of 115,502 mother–infant dyads who delivered at 25 hospitals between 2008 and 2011. The inclusion criteria for this analysis were low-risk parous women with nonanomalous singletons with at least one prior vaginal delivery after 20 weeks, who delivered at ≥390/7 weeks. Women who electively induced between 390/7 and 396/7 weeks were compared with women who expectantly managed ≥390/7 weeks. The primary outcome for this analysis was cesarean delivery. Secondary outcomes were composites of maternal adverse outcome and neonatal adverse outcome. Multivariable logistic regression was used to estimate adjusted odds ratios (aOR).
Results Of 20,822 women who met inclusion criteria, 2,648 (12.7%) were electively induced at 39 weeks. Cesarean delivery was lower among women who underwent elective induction at 39 weeks than those who did not (2.4 vs. 4.6%, adjusted odds ratio [aOR]: 0.70, 95% confidence interval [CI]: 0.53–0.92). The frequency of the composite maternal adverse outcome was significantly lower for the elective induction cohort as well (1.6 vs. 3.1%, aOR: 0.66, 95% CI: 0.47–0.93). The composite neonatal adverse outcome was not significantly different between the two groups (0.3 vs. 0.6%; aOR: 0.60, 95% CI: 0.29–1.23).
Conclusion In low-risk parous women, elective induction of labor at 39 weeks was associated with decreased odds of cesarean delivery and maternal morbidity, without an increase in neonatal adverse outcomes.
Key Points
Landau quantized dynamics and spectrum of the diced lattice
Authors: Horing N J M 
Published: September 2020

Abstract
In this work the role of magnetic Landau quantization in the dynamics and spectrum of diced lattice charge carriers is studied in terms of the associated pseudospin 1 Green’s function. The equations of motion for the 9 matrix elements of this Green’s function are formulated in position/frequency representation and are solved explicitly in terms of a closed form integral representation involving only elementary functions. The latter is subsequently expanded in a Laguerre eigenfunction series whose frequency poles identify the discretized energy spectrum for the Landau-quantized diced lattice as

ϵ

n

=
±

2

(

2
n
+
1

)

α

2

e
B

(

α

2

is the characteristic speed for the diced lattice) which differs significantly from the nonrelativistic linear dependence of ϵ

n
on B, and is similar to the corresponding

B

−

dependence of other Dirac materials (graphene, group VI dichalcogenides).
Comparison between thermophysical and tribological properties of two engine lubricant additives: electrochemically exfoliated graphene and molybdenum disulfide nanoplatelets
Authors: Guimarey María J G , Abdelkader Amor M , Comuñas María J P , Alvarez-Lorenzo Carmen , Thomas Ben , Fernández Josefa , Hadfield Mark 
Published: September 2020

Abstract
Recently graphene and other 2D materials were suggested as nano additives to enhance the performance of nanolubricants and reducing friction and wear-related failures in moving mechanical parts. Nevertheless, to our knowledge there are no previous studies on electrochemical exfoliated nanomaterials as lubricant additives. In this work, engine oil-based nanolubricants were developed via two-steps method using two different 2D nanomaterials: a carbon-based nano additive, graphene nanoplatelets (GNP) and a sulphide nanomaterial, molybdenum disulfide (MoS2) nanoplatelets (MSNP). The influence of these nano additives on the thermophysical properties of the nanolubricants, such as viscosity index, density and wettability, was investigated. The unique features of the electrochemical exfoliated GNP and MSNP allow the formulation of nanolubricant with unusual thermophysical properties. Both the viscosity and density of the nanolubricants decreased by increasing the nanoplatelets loading. The effect of the nano additives loading and temperature on the tribological properties of nanolubricants was investigated using two different test configurations: reciprocating ball-on-plate and rotational ball-on-three-pins. The tribological specimens were analysed by scanning electron microscopy (SEM) and 3D profiler in order to evaluate the wear. The results showed significant improvement in the antifriction and anti-wear properties, for the 2D-materials-based nanolubricants as compared with the engine oil, using different contact conditions. For the reciprocal friction tests, maximum friction and worn area reductions of 20% and 22% were achieved for the concentrations of 0.10 wt% and 0.20 wt% GNP, respectively. Besides, the best anti-wear performance was found for the nanolubricant containing 0.05 wt% MSNP in rotational configuration test, with reductions of 42% and 60% in the scar width and depth, respectively, with respect to the engine oil.
Controllable synthesis of Fe3O4-based magneto-dielectric ternary nanocomposites and their enhanced microwave absorption properties
Authors: Liu Juncen , Yang Zhihong , Li Meng , Yang Lieji , Xue Tong , Xu Guoyue 
Published: September 2020

Abstract
In order to overcome the drawbacks of Fe3O4 composite samples and greatly increase their performance in microwave absorption, magnetic Fe3O4 spindles coated with dielectric SnO2 nanorods and MnO2 nanoflakes have been successfully synthesized by a four-step simple hydrothermal route. This rationally designed magneto-dielectric ternary nanocomposite will introduce multiple reflection and conductive losses caused by its special multilayer structure and the effective complementarity of dielectric loss and magnetic loss. Therefore, its absorbing performance can be greatly improved. It is notable that the as-prepared Fe3O4@SnO2@MnO2 nanocomposites show a minimum reflection loss value of −50.40 dB at 17.92 GHz at a thickness of 3.9 mm and the absorption bandwidth ranges from 3.62 to 12.08 GHz. The as-prepared Fe3O4@SnO2@MnO2 ternary nanocomposite is expected to be a potential candidate for high-performance microwave-absorbing materials with intensive electromagnetic wave absorption and wide effective absorbing bandwidth.
CT-based attenuation correction of whole-body radiotherapy treatment positioning devices in PET/MRI hybrid imaging
Authors: Taeubert Leticia , Berker Yannick , Beuthien-Baumann Bettina , Hoffmann Aswin L , Troost Esther G C , Kachelrieß Marc , Gillmann Clarissa 
Published: September 2020

Abstract

Objective.To implement computed tomography (CT)-based attenuation maps of radiotherapy (RT) positioning hardware and radiofrequency (RF) coils to enable hybrid positron emission tomography/magnetic resonance imaging (PET/MRI)-based RT treatment planning. Materials and Methods. The RT positioning hardware consisted of a flat RT table overlay, coil holders for abdominal scans, coil holders for head and neck scans and an MRI compatible hip and leg immobilization device. CT images of each hardware element were acquired on a CT scanner. Based on the CT images, attenuation maps of the devices were created. Validation measurements were performed on a PET/MR scanner using a 68Ge phantom (48 MBq, 10 min scan time). Scans with each device in treatment position were performed. Then, reference scans containing only the phantom were taken. The scans were reconstructed online (at the PET/MRI scanner) and offline (via e7tools on a PC) using identical reconstruction parameters. Average reconstructed activity concentrations of the device and reference scans were compared. Results. The device attenuation maps were successfully implemented. The RT positioning devices caused an average decrease of reconstructed PET activity concentration in the range between −8.3 ± 2.1% (mean ± SD) (head and neck coil holder with coils) to −1.0 ± 0.5% (abdominal coil holder). With attenuation correction taking into account RT hardware, these values were reduced to −2.0 ± 1.2% and −0.6 ± 0.5%, respectively. The results of the offline and online reconstructions were nearly identical, with a difference of up to 0.2%. Conclusion. The decrease in reconstructed activity concentration caused by the RT positioning devices is clinically relevant and can successfully be corrected using CT-based attenuation maps. Both the offline and online reconstruction methods are viable options.
Fast-ion velocity-space tomography using slowing-down regularization in EAST plasmas with co- and counter-current neutral beam injection
Authors: Madsen B , Huang J , Salewski M , Järleblad H , Hansen P C , Stagner L , Su J , Chang J F , Fu J , Wang J F , Liang L Z , Zhong G Q , Li Y Y , Lyu B , Liu H Q , Zang Q , Luo Z P , Nocente M , Moseev D , Fan T S , Zhang Y M , Yang D , Sun J Q , Liao L Y 
Published: September 2020

Abstract
We demonstrate 2D reconstructions of the fast-ion velocity distribution from two-view fast-ion D-alpha (FIDA) measurements at the EAST tokamak. By expressing the distribution in a basis relying on the fast-ion slowing-down process in fusion plasmas, the smoothness and velocity-space resolution of reconstructions are improved. We reconstruct distributions of fast ions born from simultaneous co- and counter-current neutral beam injection and detect the expected distinct change in fast-ion birth pitch when comparing discharges utilizing different neutral beam injectors. For purely co-current injection, we find a good agreement between TRANSP-predicted and reconstructed fast-ion densities, pressures and current densities for energies above 20 keV. We furthermore illustrate the improvement of the reconstructed high-energy range (> 40 keV) of the distribution by combining FIDA with neutron emission spectroscopy measurements with the compact single-plate EJ301 scintillator.