bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender Differences in Anger Among Hospital Medical Staff Exposed to Patients with COVID-19 in a German Tertiary Center
Authors: Wesemann Ulrich , Hadjamu Nino , Wakili Reza , Willmund Gerd , Vogel Judith , Rassaf Tienush , Siebermair Johannes 
Published: August 2020

Abstract
Occupational exposure to patients with COVID-19 is a stress factor. The aim of this study was to assess gender differences in anger among medical hospital staff. N = 78 hospital employees completed State-Trait Inventory-2. Female personnel showed higher scores in the main “trait anger” scale and its subscale “anger temperament”, while “anger control-out” was significant lower. More specific training for female hospital staff could achieve health-related equality. Focusing on anger as a leading indicator could lead to better prevention and self-monitoring.
NOB1 Assumes Signifying Capacity in Lung Cancer Diagnosis.
Authors: Yang Jun , Zhong Hua , Yang Qinghui , Yu Jian , Jin Cailing , Li Xiaorui 
Published: August 2020

Abstract
Background: NIN1/RPN12 binding protein 1 homolog (NOB1) gene was reported to play a key role in the oncogenesis and prognosis of carcinomas. The aim of the present study was to investigate the expression of NOB1 and its clinical significance in lung cancer, and further explore the diagnostic value of NOB1 in lung cancer patients.Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression of NOB1 in 97 lung cancer patients and 55 healthy controls. The associations of NOB1 mRNA expression with clinicopathological factors of lung cancer patients were analyzed by Chi-square test. The receiver operating characteristics (ROC) curve was used to evaluate the diagnostic value of NOB1 in lung cancer.Results: The expression levels of NOB1 mRNA in lung cancer samples were significantly up-regulated compared with healthy controls (P<0.001). And the NOB1 expression was significant correlated with differentiation (P=0.005) and invasion depth (P=0.008). No associations were found between NOB1 expression and other factors (All P>0.05). ROC curve revealed that the area under ROC curve (AUC) was 0.885, with a sensitivity of 76.3% and a specificity of 89.1%. And the cutoff value of NOB1 was 2.225.Conclusion: NOB1 is a sensitive and specific diagnostic marker for lung cancer, and provide a new therapeutic target for lung cancer treatment.
Design of Running Training Assistance System Based on Blockchain And Wireless Sensor Technology
Authors: Ma Fuxing 
Published: August 2020

Abstract
Running exercise can increase the basal metabolic rate and increase the time of aerobic exercise. It is a healthy and effective exercise method. Based on the current needs of the general public for running auxiliary training, this article combines wireless sensing and blockchain technology in the design scheme, and designs and implements a running training auxiliary technology. First, obtain the user's gait information and other related parameters in the process through the wireless sensor network, and optimize the calculation gait in different states through the noise processing algorithm. Then, use the blockchain technology to design a data transmission and storage plan for the protection and analysis of the user's personal privacy data. This technology builds a new type of sports training assistance system for the masses of modern society and contributes to the masses' physical exercise.
HAMP: A Knowledge-base of Antimicrobial Peptides from Human Microbiome
Authors: Mulpuru Viswajit , Semwal Rahul , Varadwaj Pritish Kumar , Mishra Nidhi 
Published: August 2020

Background:
Antimicrobial peptides (AMPs) can defend the hosts against various
pathogens and are found in almost every life form from microorganisms to humans. As the rapid
increase of drug-resistant strains in recent years is presenting a serious challenge to healthcare,
antimicrobial peptides (AMPs) can revolutionize the antimicrobial development against the drugresistant
microbes.

Objective:
The objective was to encourage the study on the human microbiome towards the
inhibition of drug-resistant bacteria by the development of a database containing antimicrobial
peptides from the human microbiome.

Methods:
This database is an outcome of an extended analysis of human metagenome, involving
the prediction of coding regions, extraction of peptides, prediction of antimicrobial peptides, and
modeling their structure utilizing different in silico tools. Furthermore, an intelligent hash
function-based query engine was designed to validate the novelty of specific candidate peptide
over the reported Knowledge-base.

Result and Discussion:
This Knowledge-base currently focuses on antimicrobial peptide
sequences (AMPs) predicted from the human microbiome along with their 3D structures modeled
using various modeling and molecular dynamics approaches. It includes a total of 1087 unique
AMPs from various body sites, with 454 AMPs from the oral cavity, 180 AMPs from the
gastrointestinal tract, 42 AMPs from the skin, 12 AMPs from the airway, 6 AMPs from the
urogenital tract and 393 AMPs from undefined body locations. A scoring matrix has been
generated based on the similarity scores of the sequences that have been incorporated into the
Knowledge-base. Furthermore, a Jmol applet is included in the website to help users visualize the
3D structures.

Conclusion:
The information and functions of the Knowledge-base can offer great help in finding
novel antimicrobial drugs, especially towards finding inhibitors for drug-resistant bacteria. The
HAMP is freely available at https://bioserver.iiita.ac.in/amp/index.html.
Recent Patents for Space Docking Mechanism
Authors: Dai Ye , Gao Yu-Fei , Wen Wan-Jian 
Published: August 2020

Background:
Space docking technology and space docking mechanism are indispensable
parts of modern complex spacecraft and important means to expand satellite functions in the future.
However, there is still some technology to be broken through in the research of their buffer and locking,
so that the docking mechanism can be better used in the future.

Objectives:
Through the introduction and discussion of the characteristics of space docking mechanism patents in recent
years, some valuable conclusions are summarized, and the future research and development of space docking mechanism
are prospected.

Methods:
This paper studied the patents of various docking mechanism, and summarized the patents and research
progress of docking mechanism in space.

Results:
With the development of space industry, docking mechanism has become more and more important. So the
docking mechanism are needed to achieve the replenishment for long-term spacecraft in orbit, personnel exchange,
spacecraft maintenance, and so on.

Conclusion:
By elaborating on the structural characteristics of the docking mechanism, the importance
of the docking mechanism is consulted for investigation. Through the comparison of these patents, it is
concluded that weak impact docking mechanism and electromagnetic docking mechanism are the main
development trends of docking institutions in the future.
My Diabetes Coach, a Mobile App–Based Interactive Conversational Agent to Support Type 2 Diabetes Self-Management: Randomized Effectiveness-Implementation Trial
Authors: Gong Enying , Baptista Shaira , Russell Anthony , Scuffham Paul , Riddell Michaela , Speight Jane , Bird Dominique , Williams Emily , Lotfaliany Mojtaba , Oldenburg Brian 
Published: August 2020

Background
Delivering self-management support to people with type 2 diabetes mellitus is essential to reduce the health system burden and to empower people with the skills, knowledge, and confidence needed to take an active role in managing their own health.

Objective
This study aims to evaluate the adoption, use, and effectiveness of the My Diabetes Coach (MDC) program, an app-based interactive embodied conversational agent, Laura, designed to support diabetes self-management in the home setting over 12 months.

Methods
This randomized controlled trial evaluated both the implementation and effectiveness of the MDC program. Adults with type 2 diabetes in Australia were recruited and randomized to the intervention arm (MDC) or the control arm (usual care). Program use was tracked over 12 months. Coprimary outcomes included changes in glycated hemoglobin (HbA1c) and health-related quality of life (HRQoL). Data were assessed at baseline and at 6 and 12 months, and analyzed using linear mixed-effects regression models.

Results
A total of 187 adults with type 2 diabetes (mean 57 years, SD 10 years; 41.7% women) were recruited and randomly allocated to the intervention (n=93) and control (n=94) arms. MDC program users (92/93 participants) completed 1942 chats with Laura, averaging 243 min (SD 212) per person over 12 months. Compared with baseline, the mean estimated HbA1c decreased in both arms at 12 months (intervention: 0.33% and control: 0.20%), but the net differences between the two arms in change of HbA1c (−0.04%, 95% CI −0.45 to 0.36; P=.83) was not statistically significant. At 12 months, HRQoL utility scores improved in the intervention arm, compared with the control arm (between-arm difference: 0.04, 95% CI 0.00 to 0.07; P=.04).

Conclusions
The MDC program was successfully adopted and used by individuals with type 2 diabetes and significantly improved the users’ HRQoL. These findings suggest the potential for wider implementation of technology-enabled conversation-based programs for supporting diabetes self-management. Future studies should focus on strategies to maintain program usage and HbA1c improvement.

Trial Registration
Australia New Zealand Clinical Trials Registry (ACTRN) 12614001229662; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12614001229662
CELASTROL NANOEMULGEL FORMULATION AND IN VITRO PENETRATION TEST
Authors: ABDULLAH NUR ALAM , JUFRI MAHDI , MUNIM ABDUL , SAPUTRI FADLINA CHANY 
Published: August 2020

Objective: To obtain formulations of Celastrol (Cst) nanoemulgel via transdermal route. Celastrol is classified in BCS 4 class as an anti-inflammatory drug. These routes are considered to reduce the risk of Celastrol side effects and have the same characteristics as skin morphology.
Methods: Celastrol nanoemulgel was prepared by a high-pressure homogenizer (HPH) technique. To find the optimum nanoemulsion area by using the Chemix 7.00 ternary phase program. Celastrol nanoemulgel was evaluated by measuring the particle size, PDI, morphology, zeta potential, stability tests and in vitro using Franz diffusion cell
Results: Results showed the ideal formula based on the ternary phase diagram using chemix 7.00 is oil: smix: water (5:45:50), with particle size 89.9±5 nm, PDI 0.1, and zeta-21 mV. The morphological shape is quite spherical ≤ 100±5 nm. The pH value of this formula is 4.5, which compatible with the pH of the skin. The highest recovery rate of Celastrol and encapsulation efficiency (EE) were formulas 3 μg/ml and 5 μg/ml, with EE 91.70% and 94.54%, respectively. In vitro test results showed that the formula 3 μg/ml and 5 μg/ml give better penetration results than the formula 2.5 μg/ml. Thus, Celastrol nanoemulgel formula has good potential to be developed as a transdermal anti-inflammatory drug.
Conclusion: Transdermal nanoemulgel containing Celastrol has been successfully developed with particle size ≤ 200±2 nm.
PROTECTIVE ROLE OF BERBERINE IN AMELIORATING DIABETIC COMPLICATIONS IN STREPTOZOTOCIN-HIGH FAT DIET MODEL IN EXPERIMENTAL ANIMALS
Authors: BANDAWANE DEEPTI D. , MOOLIYA SHRUTI B. , JADHAV SHAILAJA B. 
Published: August 2020

Objective: Diabetes mellitus is a serious, complex metabolic disorder and growing health threat disease in the world. Berberine, one of the main constituent in Rhizoma coptidis is widely used in the treatment of diabetes. Potential of berberine in the management of diabetic complications, namely diabetic nephropathy and cardiomyopathy, is however, not yet explored. The present study was, therefore, undertaken to explore the potential of berberine for the management of diabetic nephropathy and diabetic cardiomyopathy in high-fat diet (HFD) and low dose streptozotocin (STZ) induced diabetes in rats.
Methods: Rats were fed a high-fat diet for 4 w followed by a single intraperitoneal dose of streptozotocin (35 mg/kg). Animals were divided in five groups. Berberine was given orally in two different dose levels (75 mg/kg and 150 mg/kg) for 28 d. Metformin (100 mg/kg) was used as a standard antidiabetic drug. At the end of the study, parameters evaluated includes glycemic profile, lipid profile, left ventricular indices, urinary protein, serum creatinine, blood urea nitrogen and cardiac antioxidants. Histopathology of kidney and pancreas was carried out.
Results: Berberine treated groups showed a significant decrease in fasting blood glucose, glycosylated Hb, creatinine, blood urea nitrogen and urinary total proteins, whereas there was a significant improvement in serum insulin, liver glycogen, skeletal muscle glycogen and cardiac antioxidant enzymes.
Conclusion: Present study indicated that berberine shows a protective role in diabetes-associated renal and cardiovascular complications.
COMPARATIVE STUDY OF LIPID PROFILE IN PATIENTS OF NON-DIABETIC CHRONIC KIDNEY DISEASE IN RELATION TO ITS SEVERITY
Authors: BEHERA BIBHU PRASAD 
Published: August 2020

Objective: Chronic Kidney Disease (CKD) is a silent epidemic of the 21st century. Cardiovascular disease (CVD) is a major cause of morbidity and mortality among patients with CKD. This study aims to evaluate the type of dyslipidemia in CKD patients and correlates with the severity of renal dysfunction in CKD patients.
Methods: The observational study was conducted in the Department of General Medicine, PRM MCH, Baripada between May 2018 and January 2019. 262 patients of CKD above 15 y of age, satisfying the inclusion and exclusion criteria were included in the study.
Results: Out of 262 patients, 64.50% (169) were male and 35.50% (93) were females with M: F of 1.8:1. The age range was from 20 to 95. The average age of the patients in the study was 56.66+12.22 y. 45.04 % (118) of the patients were between 46 and 60 y of age. 68.70% of the patients had dyslipidemia. The comparison between lipid profiles of cases and controls showed a significant increase in total cholesterol, triglyceride, LDL and decrease in HDL.
Conclusion: The prevalence of dyslipidemia in non-diabetic CKD is high. A high degree of abnormality is found in HDL with disease progression, which is statistically significant. Therefore, maintenance of desired lipid levels either through diet or early initiation of lipid-lowering drugs can be helpful in decreasing the risk of cardiovascular complications in CKD patients.
PRESCRIPTION PATTERN AND USAGE OF ANTIMICROBIAL AGENTS FOR TREATING DIABETIC FOOT INFECTIONS AT TERTIARY CARE CENTRE
Authors: RAJESH DASARAJU , ADVAITHA M. V. , HOLLA RAJENDRA 
Published: August 2020

Objective: Due to the uncertainty about optimal antibiotic treatment, and probably substantial variation in practice, the present study was carried out to determine the bacterial profiles of infected diabetic foot ulcers (DFUs) and also to analyze the prescribing pattern of antibiotics used.
Methods: A prospective observational study was carried out in the department of General surgery at a tertiary care teaching hospital, Mangalore. Demographic details and treatment data of 78 patients were collected in a specially designed Proforma, and the data were analyzed using Microsoft Excel.
Results: According to Meggit-Wagner's classification, patients admitted with DFUs predominantly belonged to WAGNER 1 category (36%), followed by WAGNER 4 (26%) and WAGNER 2 (22%) categories. Out of 66 culture-positive specimens, 21 (31.8%) had monomicrobial flora, and 45 (68.2%) had polymicrobial flora. A total of 148 organisms were obtained from the specimens. The most common isolates were Staphylococcus aureus (22.3%) and Pseudomonas aeruginosa (17.5%). Ceftriaxone was the most commonly prescribed empirical antibiotic (29%), followed by linezolid (20%), piperacillin-tazobactam (20%), amoxicillin-clavulanic acid (13%), cefoperazone-sulbactam (11%). After the culture and sensitivity (C/S) results, antimicrobials were changed in 74.61% of patients in the preference of Linezolid (51%), Amikacin (27%), Levofloxacin (19%), Ciprofloxacin (17%), Piperacillin-tazobactam (13%), Cefixime (15%), Ceftriaxone (11%) among others. Clindamycin and metronidazole were used to cover anaerobic microorganisms.
Conclusion: Most of the microorganisms isolated from DFUs were resistant to many types of antibiotics. Gram-positive organisms were largely sensitive to linezolid and vancomycin, while Gram-negative organisms to amikacin and imipenem. Local treatment of wounds is essential.
Graphic instinct: the account of graphic instinct: the account of rhetorical action and its instinctive roots in Peirce’s classification of practical sciences
Authors: Topa Alessandro 
Published: August 2020

Em um artigo intimamente relacionado a este, mostramos que o estudo mais maduro de Peirce sobre a retórica especulativa, em Ideas, Stray or Stolen, about Scientific Writing (1904), nos convida a refletir e apreender o fenômeno da retórica em sua totalidade. Seguindo pistas aristotélicas, Peirce – implicitamente – diferencia três aspectos categoriais da ação retórica, diferenciando entre (i) sua potencialidade [δύναμις] e perfeição [ἐντελέχεια] como uma faculdade instintiva de tornar signos eficazes em uma utópica arte universal, (ii) sua atualidade como um discurso prático normativo historicamente eficaz e que molda a prática retórica [τέχνη], referida como retórica comum; e (iii) sua formalidade, articulada pela investigação puramente teórica [θεωρία] das condições necessárias da eficiência dos signos em geral, intitulada Retórica Especulativa. Assim como nosso modo de ser com os outros em um mundo comum de compartilhamento de propósitos, a retórica, tanto para Aristóteles quanto para Peirce, constitui uma forma semiótica do summum bonum, cujo cultivo é essencial para o crescimento da razoabilidade concreta em qualquer comunidade política e na civilização como um todo. No presente artigo, começamos reconstruindo o relato da retórica de Peirce, no quadro de sua classificação das ciências práticas (Seção 2.1), e depois mostramos como esse relato da retórica como uma faculdade enraizada no “Instinto Gráfico” confirma a análise que apresentamos no trabalho anterior (Seções 2.2-2.3). Na seção final, tentaremos esboçar em que sentido a importância de conceber a retórica como uma δύναμις com uma ἐντελέχεια específica, ou “potencialidade-ideia” do aperfeiçoamento do desenvolvimento, pode nos ajudar a apreciar o papel histórico emancipatório que Peirce atribui às Ciências Normativas (Seção 3).
COVID 19 - Perceptions of a Primary Health Network in Australia
Authors: Nankervis Richard , Alexander Heather , Briggs David , Turner Catherine , Martin Amanda , Baillie John , Rigby Kevin 
Published: August 2020

The Covid-19 pandemic is still current but has been particularly well addressed, so far, in the Australian context. This article presents an analysis of management practice to describe the experience of one Primary Health Network (PHN) and its approach and response to the pandemic within its geographical region in accordance with Federal government directives. The PHN is a large geographic area that includes the Central Coast, just north of the Sydney basin, the Newcastle and Hunter Valley region and the Northwest/New England region that extends from Tamworth to the Queensland Border.
The article describes the PHN function within its primary healthcare role (PHC) in respect to responding to national initiatives to address and reduce the impact Of the Covid-19 event. The article recounts the Federal Governments directive described through the ‘National Cabinet’ and the Federal Health Department and the PHN response to those directives and initiatives. The article also recounts the actual cases of Covid-19 over the period of the epidemic.
The article describes the governance, leadership, and management initiatives. The article then describes the PHN approach to evaluation of its approach from the perspective of general practice and other PHC providers as well as providing perspectives from governance, management, and staff. The evaluation process identified significant impacts on providers and strong support for the continuation of telehealth measures. There were positive responses to the PHN activity and as a strong sense of trusted information, ongoing education, and general engagement.
O Brasil na crise das ilhas Chincha: a atuação diplomática de Francisco de Varnhagen (1864-1866)
Authors: Ribas Miranda José Augusto 
Published: August 2020

Este artigo analisa a atuação do diplomata brasileiro Francisco Adolfo de Varnhagen durante a crise das ilhas Chincha, que colocou Espanha contra Peru, Chile, Equador e Bolívia entre os anos de 1864 e 1866. A atuação de Varnhagen demonstra o posicionamento dúbio da chancelaria brasileira ante a conflitos entre vizinhos sul-americanos e potências europeias, ilustrando as inseguranças da política externa brasileira entre a Europa e a América. Varnhagen contrariou as disposições essencialmente neutras do Itamaraty, soltando notas de apoio aos vizinhos sul-americanos, e foi repreendido por isso. O artigo lança mão de extensa documentação diplomática brasileira e fornece novas perspectivas para entender este conflito importante na historiografia peruana, chilena e espanhola.
Palavras Chave: Diplomacia, América do Sul, Varnhagen, Política Externa.
Influencia de ENOS en la hidrometeorología de la Cuenca Alta del Río Neuquén
Authors: Groch Damián , Cogliati Marisa Gloria , Finessi Florencia Gisella 
Published: August 2020

La interacción océano-atmósfera actúa como forzante de los sistemas hidrológicos en diferentes escalas temporales, siendo El Niño-Oscilación Sur (ENOS) uno de ellos. Este trabajo presenta el análisis de variables hidrometeorológicas y su asociación con el Índice Oceánico del Niño (ONI), representativo de ENOS, en la Cuenca Alta del Río Neuquén para el período 2000-2014. Se ha detectado una débil correlación (r de 0,35). La precipitación, la temperatura, el caudal, el Equivalente de Agua en Nieve y el Área Cubierta de Nieve (ACN) presentaron una débil asociación con el ONI, con un coeficiente de correlación medio de 0,35 y un nivel de significación del 5% en la Cuenca Alta del Río Neuquén (CARN) para el período 2000-2014. El ACN presentó una correlación muy débil, entre -0,07 para El Niño y 0,14 para La Niña, mientras que las correlaciones entre el caudal y el ONI fueron de 0,51 para la totalidad del período y 0,31 para las fases de El Niño al 5% de significación, sin ser significativas para períodos de La Niña