bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combinatorial Synthesis of Novel 9R-Acyloxyquinine Derivatives as Insecticidal Agents
Authors: Che Zhiping , Yang Jinming , Sun Di , Tian Yuee , Liu Shengming , Lin Xiaomin , Jiang Jia , Chen Genqiang 
Published: January 2020

Background:
It is one of the effective ways for pesticide innovation to develop new
insecticides from natural products as lead compounds. Quinine, the main alkaloid in the bark of
cinchona tree as well as in plants in the same genus, is recognized as a safe and potent botanical
insecticide to many insects. The structural modification of quinine into 9R-acyloxyquinine
derivatives is a potential approach for the development of novel insecticides, which showed more
toxicity than quinine. However, there are no reports on the insecticidal activity of 9Racyloxyquinine
derivatives to control Mythimna separata.

Methods:
Endeavor to discover biorational natural products-based insecticides, 20 novel 9Racyloxyquinine
derivatives were prepared and assessed for their insecticidal activity against M.
separata in vivo by the leaf-dipping method at 1 mg/mL.

Results:
Among all the compounds, especially derivatives 5i, 5k and 5t exhibited the best
insecticidal activity with final mortality rates of 50.0%, 57.1%, and 53.6%, respectively.

Conclusion:
Overall, a free 9-hydroxyl group is not a prerequisite for insecticidal activity and C9-
substitution is well tolerated; modification of out-ring double-bond is acceptable, and
hydrogenation of double-bond enhances insecticidal activity; Quinine ring is essential and open of
it is not acceptable. These preliminary results will pave the way for further modification of quinine
in the development of potential new insecticides.
Exploiting XG Boost for Predicting Enhancer-promoter Interactions
Authors: Yu Xiaojuan , Zhou Jianguo , Zhao Mingming , Yi Chao , Duan Qing , Zhou Wei , Li Jin 
Published: January 2020

Background:
Gene expression and disease control are regulated by the interaction
between distal enhancers and proximal promoters, and the study of enhancer promoter interactions
(EPIs) provides insight into the genetic basis of diseases.

Objective:
Although the recent emergence of high-throughput sequencing methods have a
deepened understanding of EPIs, accurate prediction of EPIs still limitations.

Methods:
We have implemented a XGBoost-based approach and introduced two sets of features
(epigenomic and sequence) to predict the interactions between enhancers and promoters in
different cell lines.

Results:
Extensive experimental results show that XGBoost effectively predicts EPIs across three
cell lines, especially when using epigenomic and sequence features.

Conclusion:
XGBoost outperforms other methods, such as random forest, Adadboost, GBDT, and
TargetFinder.
Hepatitis E Genotype 1 Outbreak in Jharkhand, India: A Descriptive Analysis
Authors: Mehta Neelam , Gupta Minakshi , Mishra Minakshi , Singh Santosh Kumar 
Published: January 2020

Introduction:
A waterborne outbreak of hepatitis E virus occurred in the Jamshedpur city
of Jharkhand from March 2018 to October 2018. The aim of the present study is to study the hepatitis
E virus outbreak clinically, serologically and etiologically.

Methods:
Five hundred and eighty-four clinically and biochemically documented cases were
screened for the hepatotropic viral markers (HepatitisA, B, C, and E) by the ELISA. Demographic
data such as gender, age, clinical diagnosis, location, outcome and time of admission were extracted
from the online hospital management system. Water samples from the affected area were tested for
HEV RNA detection. Genotyping of HEV virus was carried out by sequencing and phylogenetic
analysis.

Results:
Hepatitis E genotype 1 was confirmed as the major etiological agent in this outbreak due to
the faecal contamination of drinking water supply while establishing illegal water connections.
Mixed infection of HEV-HAV (5.31%) or HEV-HBV (0.91%) was also detected in the present
series of acute viral hepatitis.

Conclusions:
The study highlights the importance of screening for both enterically transmitted hepatotropic
viral markers as well as the parenterally transmitted hepatotropic viral markers during the
outbreaks of acute viral hepatitis.
An Explainatory Study on Cooperative Investment Risk of Joint Venture Companies from an Economics of Organization Perspective
Authors: Dai Hao , Zhang Chaoqi , Yang Xiaojing 
Published: January 2020

Background:
Joint investment has increasingly become a popular investment method
for venture capitalists. From the two traditional perspectives of investors and start-ups, research on
Joint Venture Capital in the past 40 years has achieved rich results. Most recent literature is based
on research from the perspective of organisational economics, which further advances the vertical
development of research on Joint Venture Capital.

Objective:
The objective of this paper is to review research topics and core literature on Joint Venture
Capital from the perspective of organisational economics, and through introducing the model
of venture capitalists' ‘bounded rationality’ and evolutionary game in the joint investment risk
analysis. This paper distinguishes the influence of the game model on the formation of joint investment.
Finally, it reaches a conclusion and suggests a direction for future research.

Methods:
This paper finds and reviews literature on joint venture capital and dynamic game model
of joint investment risk that is collated to reduce the actual risk assumed by each investor. Additionally,
the paper summarises research topics and progress from the perspective of organisational
economics to identify possible research directions for the future.

Results:
Based on the evolutionary game method for analysis of the model of joint investment, the
following conclusion is drawn: the greater the heterogeneity of the participating entities, the smaller
the unit conflict cost benefit and the greater the probability of successful joint venture investment.
The joint investment operation mechanism will also be maintained on a long-term and stable
manner.

Conclusion:
From the perspective of organisational economics, the latest research on Joint Venture
Capital has extensively absorbed new research results of relevant disciplines. Joint Venture Capital
activities can be understood from a broader perspective and with new insights, which reflect complex
and dynamic interaction and correlative dependence on network members. To establish a more
successful joint investment model, the paper introduces a relatively novel evolutionary game method
for analysis of the joint investment model.
Synthesis, Characterization and Evaluation of Antioxidant and Antimicrobial activity of Spirochromones Derivatives
Authors: Shinde Achut R. , Muley Dyanoba B. 
Published: January 2020

Background:
Plethora of literature reported hitherto, depicts impending biological activities
for spirochromones. This fact encouraged us for the exploration of the synthesis of new
substituted spirochromones and their evaluation of their bioactivities.

Objective:
To synthesize different substituted spirochromones derivatives from a spirochromones salt
using (R)-pyroglutamic acid as catalyst and their evaluation for antimicrobial and antioxidant activities.

Methods:
Herein, Aldol cascade method was used for the syntheses of spirochromone derivatives
from its salt. A mild protocol is developed for the syntheses of spirochromones derivatives by using
(R)-pyroglutamic acid as catalyst. Further, the derivatives and its precursor salt were screened
for antimicrobial and antioxidant activity. The antioxidant potentials of the synthesized compounds
were checked by DPPH and hydroxyl free radical scavenging assay. Consequently, in vitro antimicrobial
activities were performed by well diffusion assay against gram negative bacterium (E.
coli) and gram positive bacterium (S. aureus).

Results:
In the present work, 10 synthesized derivatives are obtained in harmonious yield from a
precursor spirochromones salt using (R)-pyroglutamic acid as catalyst. Amongst the studied compounds,
6a depicted maximum antimicrobial activity against the screened microorganisms along
with maximum antioxidant activity. Albeit, the synthesized motifs showed moderate to good antioxidant
and antimicrobial activities.

Conclusion:
A mild protocol was developed for the synthesis of spirochromone derivatives from
their precursor spirochromones salt by using (R)-pyroglutamic acid as catalyst, which showed
moderate to good antimicrobial and antioxidant activity.
O retrato em ruínas e o corpo que nos olha
Authors: Serra Filomena 
Published: January 2020

Este artigo discute a pintura Olympia de Édouard Manet e a cópia pintada por Guilherme de Santa-Rita, apresentada na exposição da Academia de Belas-Artes, inaugurada em 18 de Março de 1911, entendendo que esse trabalho deve ocupar um lugar significativo na historiografia da arte em Portugal, sobretudo para a história do modernismo português nas artes plásticas. O artigo destaca a recepção dessa cópia apresentada naquela exposição, precisamente no dia anterior à Exposição Livre de 1911.
A Olympia de Santa-Rita, hoje lamentavelmente esquecida, questionou a pintura e o género do retrato em Portugal, a sua relação com o corpo logo no início do século, quando não toda a hipocrisia de uma sociedade. Relembrá-la é fundamental para a história da arte do retrato em Portugal.
Теплопроводность твердых растворов Cu-=SUB=-2-=/SUB=-ZnGe-=SUB=-1-x-=/SUB=-Sn-=SUB=-x-=/SUB=-Se-=SUB=-4-=/SUB=-
Authors: Боднарь И.В. 
Published: January 2020

Abstract Cu_2ZnGeSe_4 and Cu_2ZnSnSe_4 and Cu_2ZnGe_1 –_ x Sn_ x Se_4-alloy crystals are grown by the Bridgman method (vertical variant). The composition and structure of the crystals are determined. It is established that both the initial compounds and their alloys crystalize with the formation of tetragonal structure. The unit-cell parameters a and c of the crystals are calculated, and the dependences of these parameters on the composition of the alloys are constructed. It is shown that, under variations in the composition parameter x , the parameters a and c vary in accordance with Vegard’s law. The thermal conductivity of the Cu_2ZnGeSe_4 and Cu_2ZnSnSe_4 compounds and Cu_2ZnGe_1 –_ x Sn_ x Se_4 alloys is measured in the temperature range 300–600 K. It is found that the thermal conductivity varies with x , with a minimum for the medium composition.
Nilai Antioksidan dan Spf dari Kombinasi Minyak Biji Wijen (Sesamum indicum L.) dan Minyak Biji Bunga Matahari (Helianthus annuus L.)
Authors: Susanti Yanthy , Purba Anny Victor , Rahmat Deni 
Published: January 2020

Minyak wijen dan minyak biji bunga matahari yang mengandung Vitamin E dan β-Karoten dilaporkan memiliki aktivitas antioksidan dan tabir surya. Penelitian aktivitas tabir surya pada minyak wijen memberi hasil nilai SPF sebesar 1,77. Tujuan penelitian ini adalah untuk mendapatkan kombinasi minyak wijen dan minyak biji bunga matahari yang memiliki aktivitas antioksidan dan nilai SPF yang optimal. Metode yang digunakan untuk mengukur aktivitas antioksidan dengan metode peredaman radikal bebas, nilai SPF diperoleh dengan menghitung harga AUC kurva hubungan antara panjang gelombang dengan serapan yang dihasilkan. Hasil penelitian menunjukkan minyak wijen memiliki aktivitas antioksidan (IC50) sebesar 267 µg/mL dan nilai SPF sebesar 1,46 pada konsentrasi 125µg/mL, minyak biji bunga matahari memiliki aktivitas antioksidan (IC50) sebesar 88,37 µg/mL dan nilai SPF 1,14 pada konsentrasi 125µg/mL, kombinasi kedua minyak memiliki aktivitas antioksidan sebesar (IC50) sebesar 118,04 µg/mL dan nilai SPF 1,78 pada konsentrasi 125µg/mL.
Urban sediment in infiltration wells: A lesson from the northern area of greater Yogyakarta city
Authors: Suprayogi Slamet , Sudarmadji Sudarmadji , Malawani Muhammad Ngainul 
Published: January 2020

The development of housing in Yogyakarta eventually led to increased levels of runoff. To mitigate runoff increases, infiltration wells were constructed in a specific network. The northern part of Yogyakarta is now facing urbanization, and there are many housing blocks that are being constructed complete with the runoff drainage system. This study aims to reveal the role of the infiltration wells network about runoff and its effectiveness concerning the sediment load in the urban area. The drainage networks in the research area function as a watershed, but not with a single outlet. The runoff flow was spreading through the drainage system and did not accumulate on the single outlet. It can be seen that some infiltration wells supposed as a well, which is a place of accumulation of runoff and sediment. Most of the infiltration wells have been filled with sediment up to over a quarter, or even more than half, of their carrying volume. Granulometry measurement shows that the percentage of clay, loam, sand, and gravel in each well tend to differ for every sample. The differences between filled wells and their sediment grain depend on the location of those wells. Maintenance of the wells is required, such as sediment dredging, to rejuvenate them and improve their efficiency.
A Evolução da Análise de Sinais Biomédicos no Auxílio ao Diagnóstico Clínico
Authors: Leite Argentina , Pereira Luís Torres , Ricardo Sandra 
Published: January 2020

Resumo A análise de sinais biomédicos desempenha, atualmente, um papel fundamental no auxílio ao diagnóstico clínico. Os avanços científicos multiplicam-se a um ritmo frenético numa sociedade cada vez mais consciente e desejosa de soluções para os problemas de saúde. Este trabalho pretende dar uma perspetiva histórica dos avanços no estudo dos sinais biomédicos e refletir a sua importância na sociedade.Palavras-chave: Sinais Biomédicos; diagnóstico clínico; avanços Abstract Currently the biomedical signal analysis plays a fundamental role in helping clinical diagnosis. Scientific advances multiply at a frenetic pace in a society that is increasingly aware of and desirous of solutions to health problems. The need for constant updating of the means of clinical diagnosis is necessary to meet the demands of the world today. This work intends to give a historical perspective of advances in the biomedical signal study and to reflect its importance in society. Keywords: Biomedical Signal analysis, clinical diagnosis, scientific advances
Soil Science: from Babylon to the Present
Authors: Oliveira Manuel 
Published: January 2020

ResumoO solo é um material com características e comportamento únicos na interface das esferas biológica, hidrológica, litológica e atmosférica do nosso planeta e tem um papel vital no bem-estar humano. A história do solo tem seguido a par do uso do solo para crescer plantas, a história da agricultura desde as antigas civilizações até aos nossos dias. Até ao século 19, não houve experimentação e validação de teorias e não existiu verdadeira ciência. A ciência do solo nasceu há cerca de 150 anos com o trabalho realizado por cientistas Ingleses, Alemães, Dinamarqueses e, sobretudo, Russos. A meados do século 20, sob pressão das actividades humanas sobre o ambiente, a ciência do solo ultrapassou a sua base de conhecimento aplicada à agricultura e agronomia para abraçar temas sobre a terra e o ambiente. Nasceu o conceito de segurança do solo e este tratado no seu papel de proporcionar serviços ambientais e usado para quantificar os recursos edáficos agregando contribuições de pedologistas, economistas, sociólogos e políticos no processo de tomadas de decisões sobre o solo.Palavras-Chave: Evolução de Solo, História, CiênciaAbstractSoil is a material with unique features and behavior at the interface between the biologic, hydrologic, lithologic, and atmospheric spheres of our planet that plays a vital role in human welfare. The history of soil has been in step with the history of the use of soils to grow plants, a history of agriculture from earlier civilizations to our days. Until the 19th century, no experimentation and testing of theories were conducted and there was no real science. Soil science was born about 150 years ago with the works of English, German, Danish and, above all, Russian scientists. In mid-20th century, under pressure of human activities upon the environment, soil science out grew its base knowledge applied to agriculture and agronomy to play an ever-increased role of land and environmental issues. It was born the concept of soil security and soil was understood in its role of delivering ecosystem services and used to quantify the soil resource aggregating contributions of soil scientists, economists, social scientists and policy makers for decision- making process about soil. Keywords: Soil Evolution, History, Science Resumo
EL CRECIMIENTO URBANO Y SU INFLUENCIA EN LOS CAUDALES DE CRECIDA: UN CASO DE ESTUDIO EN UNA CUENCA URBANA EN LOS ANDES ECUATORIANOS
Authors: Oñate-Valdivieso Fernando , Oñate-Paladines Arianna 
Published: January 2020

El notable crecimiento urbano que han experimentado varias ciudades en el Ecuador en los últimos años ha provocado cambios en el uso de suelo de las cuencas hidrográficas de las que ellas forman parte. Desde el punto de vista hidrológico el cambio de uso del suelo se ve reflejado en el cambio de la respuesta de una cuenca hidrográfica a eventos extremos de precipitación. En el presente estudio se realiza un análisis multitemporal (1976- 2010) del crecimiento urbano de la ciudad de Loja, capital de la provincia ecuatoriana del mismo nombre, determinándose el crecimiento experimentado por la ciudad y la variación del uso de suelo en la cuenca del río Zamora durante el período considerando. Para la evaluación de los caudales de crecida, según las diferentes etapas de crecimiento urbano, se implementó un modelo hidrológico de evento. El análisis multitemporal del crecimiento urbano, la obtención de parámetros hidrológicos y la presentación de resultados se realizó aplicando Sistemas de Información Geográfica. Los resultados permiten demostrar la relación directa entre el crecimiento del área urbana y el incremento de la magnitud de los caudales de crecida.
Trajetórias escolares no Ensino Médio Integrado: uma análise da atribuição de sentidos de jovens estudantes por meio da história oral temática | School trajectories in integrated High School Education: An analysis of the attribution of meanings of young students through thematic oral history
Authors: Zimmermann Tânia Regina , Socorro Anselmo Silva 
Published: January 2020

Este artigo se insere na problemática dos desafios atuais do Ensino Médio brasileiro no que concerne à relação distanciada de muitos jovens frente à escola, marcada por tensão e altos índices de desistência dos estudantes. Nesta pesquisa entrevistamos 11 estudantes do Ensino Médio Integrado do Instituto Federal do Mato Grosso do Sul - Coxim, dos quais 4 foram selecionados para este artigo. A instituição foi selecionada por apresentar boa infraestrutura, docentes com alto nível de escolaridade e, em contraponto, altos índices de desistência escolar. O objetivo do estudo foi conhecer as trajetórias escolares dos jovens estudantes, bem como analisar os sentidos atribuídos à experiência escolar no Ensino Médio Integrado da instituição. As narrativas foram analisadas de forma descritiva, com base na metodologia da História Oral Temática, através da qual se estabeleceu um diálogo entre as falas dos estudantes e os interlocutores teóricos. Entre os estudantes desistentes, pôde-se observar a dificuldade de conciliação entre escola e trabalho, o desejo da independência financeira, a timidez e o excesso de reprovações. Também se observou trajetórias de êxito de estudantes ligados a iniciativas de ensino diferenciadas, embora com o reconhecimento do cansaço gerado pelas atividades escolares. Os resultados sinalizam a necessidade de ouvir e reconhecer as particularidades dos estudantes do Ensino Médio.
CHALLENGES TO THE AGRICULTURAL DEVELOPMENT POLICY WITHIN A SUBSISTENCE SOCIETY : AN ANALYSIS OF THE “REVOLUTIONARY AGRICULTURAL POLICY” IN SOUTH WESTERN SUMBA
Authors: Waskitojati Damar , Kameo Daniel , Wiloso Pamerdi G 
Published: January 2020

Employing a qualitative approach, this study attempts a critical investigation into the Kebijakan Revolusi Pertanian, ie. The Revolutionary Agricultural Policy, as it was developed by the Regional Government of South-western Sumba. During the years 2014-2019 it aimed to raise the agricultural economy, and thereby overcome the problem of poverty. The data for this research was procured through personal observation and deep interviews with sources such as key informants within the regional environment. These were reinforced with a number of planning documents and executive programs which comprise a secondary resource. The analysis of the Policy is done taking into account the relevant political, economic, technological and social aspects (PETS analysis), as well the innovations occurring during the course of this Policy. This study will demonstrate that the Policy has been, at least till now, incapable of having a significant impact on the agricultural economy, or the efforts to overcome poverty. The causes of this failure is the antagonism between the characteristics of the subsistence society found there and the weak institutional application of the policies employed.
ACCELERATE NON-ENGLISH LECTURERS’ MASTERY OF ENGLISH THROUGH CONTENT-BASED INSTRUCTION
Authors: Dilo Asna Usman 
Published: January 2020

The articles aims of discussing about using content based approach in accelerating non-English lecturers’ mastery of English. Out of three main types of Content-Based Instruction, this study uses the theme-based language instruction to accelerate the non-English lecturers’ mastery of English. Therefore, the question was asked; can the content based approach accelerate the non-English lecturers’ mastery of English. This study was an action research study, where pre-test and posttest were administered to obtain the data, in addition to observation and literature study. The study is conducted in two cycles; each cycle consists of 5 meetings. The indicator of the study is that the study is completed when 75% of the lecturers were able to reach at least 75 points in the test. The pretest reveals that the average lecturers’ score is 63.50 and following the treatment using this approach at the end of the second cycle, the average lecturers’ mastery is 80.2%. Therefore, it is concluded that content-based instruction can accelerate the non-English lecturers’ mastery of English.
Stimulating Flexible Citizenship: The Impact of Dutch and Indian Migration Policies on the Lives of Highly Skilled Indian Migrants in the Netherlands
Authors: Kirk Katherine , Bal Ellen 
Published: January 2020

Abstract
This paper explores the relationship between migration and integration policies in the Netherlands, diaspora policies in India, and the transnational practices of Indian highly skilled migrants to the Netherlands. We employ anthropological transnational migration theories (e.g., Ong 1999; Levitt and Jaworsky 2007) to frame the dynamic interaction between a sending and a receiving country on the lives of migrants. This paper makes a unique contribution to migration literature by exploring the policies of both sending and receiving country in relation to ethnographic data on migrants. The international battle for brains has motivated states like the Netherlands and India to design flexible migration and citizenship policies for socially and economically desirable migrants. Flexible citizenship policies in the Netherlands are primarily concerned with individual and corporate rights and privileges, whereas Indian diaspora policies have been established around the premise of national identity.