bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term monitoring of dynamic changes in plasma EBV DNA for improved prognosis prediction of nasopharyngeal carcinoma
Authors: Li Wanxia , Chen Jing , Liang Bijun , Li Zonghua , Li Junzheng , Yuan Xiaofei , Wu Shuting , Zeng Fangfang , Peng Xinyu , Li Yanfei , Lu Juan , Zhao Feipeng , Liu Xiong 
Published: December 2020

AbstractBackgroundThis study was performed to investigate whether long‐term monitoring of dynamic changes in plasma Epstein‐Barr virus (EBV) DNA could improve prognosis prediction of nasopharyngeal carcinoma (NPC).Materials and methodsAbout 1077 nonmetastatic NPC patients were recruited to retrospectively analyze the prognostic value of plasma EBV DNA load pretreatment and 3, 12, 24, and 36 months posttreatment. We also examined the prognostic value of dynamic changes in plasma EBV DNA at various time points.ResultsPatients with plasma EBV DNA load above optimal pre‐ and posttreatment cut‐offs had significantly worse five‐year progression‐free survival, distant metastasis‐free survival, locoregional relapse‐free survival, and overall survival (OS) at all‐time points, excluding only OS at 36 months posttreatment due to limited mortalities. Patients with persistently undetectable plasma EBV DNA at the first four time points had the best prognosis, followed by those with positive detection pretreatment and consistently negative detection posttreatment, those with negative detection pretreatment and positive detection at one time point posttreatment, and those with positive detection pretreatment and at one time point posttreatment, whereas patients with positive detection at ≥2 time points posttreatment had the worst prognosis. Cox proportional hazard models identified the dynamic change pattern as an independent prognostic factor, and receiver operating characteristic curve analysis demonstrated that the dynamic change at four time point was more valuable than any single time point for predicting disease progression, distant metastasis, locoregional relapse, and mortality.ConclusionsDynamic changes in plasma EBV DNA pre‐ and posttreatment could predict the long‐term survival outcome and provide accurate risk stratification in NPC.
An exploration of ending psychotherapy: The experiences of volunteer counsellors
Authors: Ling Lydia Success , Stathopoulou C. Haroula 
Published: December 2020

AbstractBackground/aimsLiterature suggests that the ending phase of therapy can be difficult and challenging for counsellors. Despite this, there is limited research in this area and no study has specifically looked at the experiences of volunteer counsellors. This is the first study to explore the experiences and challenges of volunteer counsellors and the impact of ending therapeutic relationships.Method/designA verbatim account of semi‐structured interview data was analysed using thematic analysis. The participants were six volunteer counsellors working in a mental health charity.FindingsThree main themes were identified during the analysis—length of therapy, impact of organisational structure and strategies for managing challenges.DiscussionThe counsellors perceived the fixed number of eight sessions as insufficient to address the presenting issues and problematic with regard to managing endings. The organisational structure (most likely influenced by the commissioning contracts) had a particular impact on these experiences. Endings were generally experienced as challenging; however, some of the participants perceived the time‐limited therapy as helpful in working with less difficult and complex issues.Clinical implicationsThe study highlighted the need for an ongoing consideration of the impact of inflexible regulations/structure by counselling organisations and funding bodies in order to empower and enable these clinicians to practice and manage endings effectively. There is need for therapeutic settings to consider flexibility of therapy length and allow volunteer counsellors to offer their services with some degree of autonomy. Services could think of creative ways of offering interventions based on clients’ needs and complexity of presenting problems.
Premedication of hemin for eradication therapy of Helicobacter pylori in patients with porphyria
Authors: Takata Tadayuki , Kokudo Yohei , Morishita Asahiro , Kume Kodai , Yachida Tatsuo , Kamada Masaki , Kobara Hideki , Deguchi Kazushi , Touge Tetsuo , Masugata Hisashi , Masaki Tsutomu 
Published: December 2020

AbstractEradication therapy of Helicobacter pylori may be safe if hemin has been intravenously administered in advance, even in patients with a history of recurrent acute porphyria attack.
Adsorption Mechanism of Bentonite with Dispersed Chitosan for Cadmium Ions
Authors: Huang Chengdu , Huang Yongchun , Xie Tenghui , Yu Wanguo , Ai Shuo 
Published: December 2020

AbstractChitosan was dispersed on bentonite for the preparation of a Cd2+ adsorbent. The adsorption process followed a Freundlich isotherm, and the experimental adsorption capacity was determined. For understanding the adsorption mechanism, the pristine and Cd‐doped adsorbents were analyzed by Fourier transform infrared and X‐ray photoelectron spectroscopy. A red shift of the band corresponding to amino groups was observed, while the Cd 3d binding energy declined. Furthermore, density functional theory calculation results indicated that Cd2+ bonded with amino and hydroxyl groups in chitosan. The zeta potential of the adsorbent was lower than that of the support bentonite, improving the electrostatic affinity for Cd2+. The synergy between electrostatic and coordination interactions contributed to the adsorption capacity.
Quality relevant fault detection of batch process via statistical pattern and regression coefficient
Authors: He Fei , Zhao Yanbo 
Published: December 2020

AbstractCompared with the normal process, the statistical values or the relationships between process variables and the quality that represent process situations would change in an abnormal batch. A novel method named quality relevant fault detection based on statistical pattern and regression coefficients (SPRC) is proposed for the batch process. Firstly, the statistical patterns of the process data, such as mean value and SD, are computed to quantify process characteristics. The regression model is built via linear methods, such as multiple linear regression, least absolute shrinkage and selection operator, to describe the linear relationship. The mutual information between the quality and the process parameters is used to characterize the nonlinear relationship. In this way, statistical patterns and regression coefficients which express batch information constitute the two‐way matrix. Then, the matrix is dimensionally reduced by related method, such as principal component analysis. The relationships hidden in batch process could be sought by SPRC. Finally, two cases, penicillin fermentation and steel hot rolling, are used to validate the feasibility and advantages of the proposed method.
Mortality in hospitalized patients with cancer and coronavirus disease 2019: A systematic review and meta‐analysis of cohort studies
Authors: Desai Aakash , Gupta Rohit , Advani Shailesh , Ouellette Lara , Kuderer Nicole M. , Lyman Gary H. , Li Ang 
Published: December 2020

BackgroundHeterogeneous evidence exists on the effect of coronavirus disease 2019 (COVID‐19) on the clinical outcomes of patients with cancer.MethodsA systematic review was performed using the Medline, Embase, and CENTRAL databases and the World Health Organization Novel Coronavirus website to identify studies that reported mortality and characteristics of patients with cancer who were diagnosed with COVID‐19. The primary study outcome was mortality, defined as all‐cause mortality or in‐hospital mortality within 30 days of initial COVID‐19 diagnosis. The pooled proportion of mortality was estimated using a random‐effects model, and study‐level moderators of heterogeneity were assessed through subgroup analysis and metaregression.ResultsAmong 2922 patients from 13 primarily inpatient studies of individuals with COVID‐19 and cancer, the pooled 30‐day mortality rate was 30% (95% CI, 25%‐35%). The overall pooled 30‐day mortality rate among 624 patients from 5 studies that included a mixture of inpatient and outpatient populations was 15% (95% CI, 9%‐22%). Among the hospitalized studies, the heterogeneity (I2 statistic) of the meta‐analysis remained high (I2, 82%). Cancer subtype (hematologic vs solid), older age, male sex, and recent active cancer therapy each partially explained the heterogeneity of mortality reporting. In multivariable metaregression, male sex, along with an interaction between the median patient age and recent active cancer therapy, explained most of the between‐study heterogeneity (R2, 96%).ConclusionsPooled mortality estimates for hospitalized patients with cancer and COVID‐19 remain high at 30%, with significant heterogeneity across studies. Dedicated community‐based studies are needed in the future to help assess overall COVID‐19 mortality among the broader population of patients with cancer.
Linear time algorithm for computing min‐max movement of sink‐based mobile sensors for line barrier coverage
Authors: Zou Wenjie , Guo Longkun , Huang Peihuang , Lin Geng , Mei Hengquan 
Published: December 2020

AbstractWitnessing broad energy‐critical applications of barrier coverage in mobile and wireless sensor networks, emerging practical applications have recently brought a new barrier coverage model which uses sink‐based mobile sensors for covering a given barrier with the aim of prolonging the lifespan of the coverage. In the model, a set of sink stations were distributed on the plane in which each sink can emit mobile sensors with an identical radius. The task is to cover a given line barrier with the emitted mobile sensors, aiming to minimize the maximum movement of the sensors so as to prolong the shortest lifespan among the sensors in coverage. In this paper, we first devise an algorithm for optimally solving the problem based on the properties of the structures called movement parity and tangent equilibrium points between the sinks. Then based on a more sophisticated geometric property of optimum solutions, we improve the runtime to a linear runtime O(k) which attains the possibly optimum runtime of the problem for k being the number of sinks. At last, numerical experiments are carried out to demonstrate the practical performance gain of our algorithms against baselines in literature.
On the Effect of the Various Assumptions and Approximations used in Molecular Simulations on the Properties of Bio‐Molecular Systems: Overview and Perspective on Issues
Authors: van Gunsteren Wilfred F. , Daura Xavier , Fuchs Patrick F. J. , Hansen Niels , Horta Bruno A. C. , Hünenberger Philippe H. , Mark Alan E. , Pechlaner Maria , Riniker Sereina , Oostenbrink Chris 
Published: December 2020

AbstractComputer simulations of molecular systems enable structure‐energy‐function relationships of molecular processes to be described at the sub‐atomic, atomic, supra‐atomic or supra‐molecular level and plays an increasingly important role in chemistry, biology and physics. To interpret the results of such simulations appropriately, the degree of uncertainty and potential errors affecting the calculated properties must be considered. Uncertainty and errors arise from (1) assumptions underlying the molecular model, force field and simulation algorithms, (2) approximations implicit in the interatomic interaction function (force field), or when integrating the equations of motion, (3) the chosen values of the parameters that determine the accuracy of the approximations used, and (4) the nature of the system and the property of interest. In this overview, advantages and shortcomings of assumptions and approximations commonly used when simulating bio‐molecular systems are considered. What the developers of bio‐molecular force fields and simulation software can do to facilitate and broaden research involving bio‐molecular simulations is also discussed.
Immunological response of human leucocytes after exposure to lipopolysaccharides from Porphyromonas gingivalis
Authors: Alizadehgharib Sara , Östberg Anna‐Karin , Dahlstrand Rudin Agnes , Dahlgren Ulf , Christenson Karin 
Published: December 2020

AbstractPorphyromonas gingivalis (P. gingivalis) is a gram‐negative bacterium and an important etiologic agent of periodontitis. P. gingivalis releases outer membrane vesicles containing lipopolysaccharides (LPS), which can penetrate periodontal tissues. Once in the periodontal tissues and in contact with immune cells, it may participate in the destructive innate host response associated with the disease. The exact mechanism of P. gingivalis LPS in the disease process is not clear, but it is known to affect a variety of immune responses.ObjectivesTo investigate how LPS from P. gingivalis affect neutrophil extracellular trap (NET) formation, cell death and production of cytokines from human neutrophils and peripheral mononuclear blood mononuclear cells (PBMCs).Materials and methodsIsolated neutrophils and PBMCs were cultured with LPS from P. gingivalis or Escherichia coli (E. coli) (control). The NET formation was measured using Sytox green stain. Cell death of neutrophils and PBMCs was analyzed using flow cytometry or Sytox green stain. Cytokine production was measured using enzyme‐linked immunosorbent assay (ELISA) kit or Bio‐Plex assay.ResultsExposure to LPS from P. gingivalis and E. coli caused significantly lower cell death in neutrophils. NETs were formed after exposure to the two different LPS. In PBMCs, exposure to P. gingivalis and E. coli LPS caused increased levels of IL‐1β and IL‐6 compared to unstimulated controls. Increased cell death in PBMCs after exposure to LPS from E. coli in comparison to LPS from P. gingivalis and unstimulated controls was also observed.ConclusionsLPS from P. gingivalis has the ability to affect both human neutrophils and PBMCs with regard to cytokine production, cell death and production of NETs. LPS from P. gingivalis could be involved in the pathogenesis of periodontitis, and our results may contribute information regarding possible markers for diagnosis and targets for treatment of periodontal disease.
Being sustainable: The three‐way interactive effects of CSR, green human resource management, and responsible leadership on employee green behavior and task performance
Authors: He Jie , Morrison Alastair M. , Zhang Hao 
Published: December 2020

AbstractThe main goal of this research was to analyze the three‐way interactive effects of corporate social responsibility (CSR), green human resource management (GHRM), and responsible leadership on employee green behavior and task performance. Social cognition theory was adopted to explore the context‐behavior‐performance framework. The research hypotheses were tested using data from a survey of 261 Millennial employees in five‐star hotels in China. The results indicated that the three‐way interactive effect of CSR, GHRM, and responsible leadership on employee green behavior and performance was significant and positive. In addition, green behavior played a mediation role in this relationship after controlling the effect of organizational identity. This suggests that behavioral improvements are a better predictor of performance than perceptions of organizational identity. The analysis enriches the context‐behavior‐performance framework literature and highlights that organizations can enhance sustainability by implementing CSR, GHRM, and responsible leadership.
Electrifying Sustainability on Transition Metal‐Free Modes: An Eco‐Friendly Approach for the Formation of C−N Bonds
Authors: Dagar Neha , Sen Partha Pratim , Roy Sudipta Raha 
Published: December 2020

AbstractEmbracing sustainable green methodologies and techniques in chemical transformations has always been in the limelight to the synthetic community. Electrosynthesis has emerged as a powerful, sustainable synthetic tool for molecular synthesis exploiting inexpensive electricity in place of sacrificial chemical oxidizing/reducing reagents. Herein, recent advances in the incorporation of transition metal‐free redox mediators in electrosynthesis for the construction of C−N bonds are outlined. Furthermore, conjugation of this strategy with flow catalysis allows easy scale up of the synthesis of molecular assembly. This comprehensive Review provides an overview of metal‐free mediated electro‐construction of C−N bonds, focusing on the reaction mechanisms involved and its synthetic applications.
OMIP 072: A 15‐color panel for immunophenotypic identification, quantification, and characterization of leukemic stem cells in children with acute myeloid leukemia
Authors: Petersen Marianne A. , Bill Marie , Rosenberg Carina A. 
Published: December 2020

AbstractThis panel was designed to identify, quantify and phenotypically characterize putative leukemic stem cells (LSCs) in bone marrow (BM) samples from individual pediatric patients diagnosed with acute myeloid leukemia (AML). Based on an aberrant expression on immunophenotypically defined hematopoietic stem cells (HSCs), several antigens have been proposed as LSC markers in AML research, using healthy adult BM samples as reference material. Generally, these antigens have been evaluated individually in smaller panels (e.g. 8‐color panels). This necessitates several tubes to characterize the LSC phenotype and compromises the ability to evaluate LSC heterogeneity. The present 15‐color OMIP incorporates nine suggested LSC markers to comprehensively capture LSC immunophenotypes and to explore heterogenic marker‐patterns within LSC populations in a single tube. Importantly, this single tube approach requires less input material, which is essential when sampling BM aspirates from pediatric patients where sample volumes often are sparse. As knowledge on normal expression levels of the included LSC markers in HSCs from hematologically healthy children are a prerequisite for labelling a phenotype as abnormal, we have evaluated the applicability of the panel on cryopreserved mononuclear cells (MNCs) isolated from BM samples from pediatric patients without hematological disorders as well as pediatric AML patients. The panel is optimized for cryopreserved BM MNCs, but could in principle, be utilized for LSC detection in any biological material containing human hematopoietic cells.
Sensory processing and cortisol at age 4 years: Procedural pain‐related stress in children born very preterm
Authors: McLean Mia A. , Niknafs Nikoo , Scoten Olivia C. , Chau Cecil M. Y. , MacKay Margot , Weinberg Joanne , Synnes Anne , Miller Steven P. , Grunau Ruth E. 
Published: December 2020

AbstractChildren born preterm display altered sensory processing, which may manifest as hyper‐ and/or hypo‐sensitivity to sensory information. In this vulnerable population, exposure to neonatal pain‐related stress is associated with altered stress regulation, as indexed by alterations in cortisol levels. It is unknown whether sensory processing behaviors are also affected by early life adversity, and whether dysregulated cortisol is related to sensory processing problems in preterm children. We examined relationships between neonatal pain‐related stress, sensory processing profiles and cortisol levels at age 4 years, and whether pathways were sex‐specific. In a longitudinal prospective cohort study, N = 146 infants born 24–32 weeks gestational age were recruited from BC Women's Hospital, Vancouver, BC, Canada; neonatal factors were collected from daily chart review. At age 4 years, saliva to assay cortisol was collected three times across cognitive assessment (pre‐test, during, end) and parents completed the Short Sensory Profile questionnaire. Using generalized linear modeling, independent of other neonatal factors, higher number of invasive procedures (pain/stress) was associated with more sensory processing problems (total, hypo‐ and hyper‐sensitivity) for girls only. After accounting for neonatal factors, greater cortisol output across the assessment was associated with more total sensory processing problems in girls only, and hypersensitivity to sensory input in both boys and girls. Findings suggest that in children born very preterm, how a child responds to sensory input and cortisol reactivity to stress are related but may have different precursors. Girls may be somewhat more susceptible to neonatal pain‐related stress exposure in relation to sensory processing at preschool age.
Kinetic and structural changes during gasification of cashew nut shell char particles
Authors: Nguyen Hong Nam , Khuong Duy Anh , Vu Thi Thu Ha , Mai Thi Nga , Tsubota Toshiki , Tran Van Bay , Blin Joel , Van De Steene Laurent 
Published: December 2020

AbstractCashew Nut Shell (CNS), an abundant waste from the cashew nut production, could become a promising material for gasification. Nevertheless, engineering data regarding this technology is still small and fragmented. In this study, the evolution of the char textural properties during gasification, as well as the effect of operating conditions on char gasification kinetics were extensively investigated and quantified. The textural properties of cashew nut shell char changed significantly following different pathways between CO2 and H2O gasification. Micropores and mesopores were well developed along with the conversion in the case of H2O gasification instead of only micropores in the case of CO2 gasification. Regarding char gasification kinetics, an increase of the temperature from 800 to 1000°C enhanced five times the conversion rate under an H2O atmosphere and 15 times under a CO2 atmosphere. The conversion rate increased two times when the concentration of reacting gases changed from 20 to 60 vol % for both atmospheres. Similarities in terms of gasification kinetics between CNS chars and wood chip chars were found in this range of operating conditions.
Phosphate bed as energy storage materials for augmentation of conventional solar still productivity
Authors: Attia Mohammed El Hadi , Driss Zied , Kabeel Abd Elnaby , Afzal Asif , Manokar A. Muthu , Sathyamurthy Ravishankar 
Published: December 2020

AbstractIn this experimental work, the phosphate bed was used to augment a Conventional Solar Still (CSS) yield. The CSS was manufactured and operated under the climatic condition of El Oued, Algeria. To evaluate the phosphate as energy storage materials in the CSS, a 10 mm thick phosphate bed was made at the distiller's bottom. The phosphate bed is considered energy storage materials with good thermal conductivity. This material acts as an energy source in the basin after sunset and at times when the intensity of solar radiation decreases. The investigational outcome confirmed that the CSS's daily output contains a phosphate bed is higher than CSS production. Daily production with phosphate bed is equal to 3.55 kg/m2, while its value is recorded at 3.04 kg/m2 for the CSS. The use of phosphate bed increases daily production by 16.8% compared to the CSS. Besides, the daily energy efficiency is 31% for the CSS with phosphate bed as storage materials and 24.6% for the CSS.