bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of imaging-based measurement techniques for free surface flows involving sediment transport and morphological changes
Authors: Soares-Frazão Sandra 
Published: June 2020

Abstract
In order to validate the numerical methods aimed at the simulation of fast transient flows involving sediment transport and morphological changes, data are required. However, field data are scarce, or, if existing, are often inaccurate or incomplete, due to the difficulty of taking reliable measurements in such difficult flow conditions. Laboratory experiments constitute a good alternative to obtain validation data for numerical models. When performing simplified experiments, a limited number of well-identified flow features can be highlighted if appropriate measurements are taken. Advances in experimental techniques in the last decades have significantly enlarged the field of possible data acquisition, especially thanks to the development of non-intrusive techniques such as digital imagery. Non-intrusive techniques are of paramount importance when considering sediment transport because a measurement device interacting with the flow would also modify the observed morphological features. In this paper, several imaging-based techniques are presented for water-level and bed evolution measurements. The key features and advantages are discussed but also the drawbacks of those techniques. The discussion is illustrated by different examples that have resulted in data sets commonly used by scientists all over the world to test their numerical simulation tools.
Study of bursting events and effect of hole-size on turbulent bursts triggered by the fluid and mid-channel bar interaction
Authors: Amir Khan Md. , Sharma Nayan 
Published: June 2020

Abstract
Turbulent structures of flow around the mid-channel braid bar have not been adequately investigated so far. Of late, the intrinsic fluvial hydraulics associated with the formation of braided rivers interspersed with sand bars have been vital topics of research. In this paper, the findings yielded from a research foray on the aforementioned underlying processes are presented. For obtaining the requisite experimental data, the three-dimensional flow velocity components are measured with the help of acoustic Doppler velocimetry (ADV) and these velocity data are analyzed using quadrant bursting techniques. The flow characteristics are greatly affected by the presence of a mid-channel bar. The depth-averaged contours of turbulent parameters are analyzed in the present study. Herein, the hole size concept is adopted for separating the bursting events. The effect of hole size on the quadrant events is also studied. The experiments are performed for different submergence ratios. A new parameter, Bursting Index (BI), is proposed in this research to reflect a quantitative measure of the turbulent bursting effect on streambed elevation changes. The parameter BI is the ratio of the odd event occurrence probability to the even event occurrence probability. The high values of correlation coefficients signify that the BI is profoundly influenced by streambed elevation changes, which makes it an ideal parameter for analyzing scour and deposition phenomena in real-life water management projects. The prime focus on performing the experiments has been to analyze the impact of bar height on flow structure in the vicinity of the mid-channel bar.
The Radiological Evaluation of Posterior Superior Alveolar Artery by Using CBCT
Authors: Karslioglu Hazal , Çitir Mesude , Gunduz Kaan , Kasap Pelin 
Published: June 2020

Background:
Evaluation of the maxillary sinus anatomy prior to sinus lift procedures is
important to avoid surgical complications due to the close anatomical relationship between the posterior
maxillary region and the maxillary sinüs.

Introduction:
In order to avoid traumatizing the posterior superior alveolar artery and to prevent perioperative
bleeding, locating the exact position of the artery is imperative before the surgical procedures.

Methods:
150 CBCT scans were evaluated. The distance from the inferior border of the PSAA to
the alveolar crest (the vertical line from the artery to the crest) and floor of the maxillary sinus, the
distance from PSAA to medial sinus wall, nasal septum, zygomatic arch, position, the distance
from the floor of maxillary üs to the alveolar crest and diameter of the PSAA were assessed. Locations
of the artery were classified.

Results:
The artery diameters were mostly ≥ 1 mm. The artery was mostly intraosseous (59.7%),
21.7% was superficial and only 18.7% was intra-sinuscular.

Conclusion:
The location of PSAA is intraosseous in most patients. The artery diameters were
mostly ≥ 1 mm and we can say that increasing the size also increases the risk of complications.
Synthesis and In Silico Studies of C-4 Substituted Coumarin Analogues as Anticancer Agents
Authors: Dandriyal Jyoti , Kaur Kamalpreet , Jaitak Vikas 
Published: June 2020

Background:
Coumarin is a fused ring system and possesses the enormous capability of
targeting various receptors participating in the cancer pathway. Coumarin and its derivatives were
found to exhibit very rare toxicity and other side effects. It has been found its immense anticancer
potential depends on the nature of the group present and its pattern of substitution on the basic nucleus.

Objectives:
Synthesis of C-4 substituted coumarin derivatives and to study their molecular interactions
with ERα for the anticancer activity for Breast Cancer.

Methods:
C-4 substituted coumarins analogues (1-10) have been synthesized using conventional
heating and microwave irradiation. Using Schrodinger software, molecular modeling studies were
carried out and ADME properties of the compounds were predicted.

Results:
All the synthesized compounds have shown better G-Score (-6.87 to -8.43 kcal/mol) as
compared to the standard drug tamoxifen (-5.28kcal/mol) and auraptene (-3.89kcal/mol). Molecular
docking suggests that all compounds fit in the active site of protein as they have the same hydrophobic
pocket as standard drug tamoxifen, and have an acceptable range of ADME properties.

Conclusion:
Microwave-assisted synthesis showed better results as compared to conventional heating.
In silico studies revealed that all the compounds befit in the active site of the protein. ADME
properties showed that all compounds are in allowable limits for human oral absorption. In the future,
there is a possibility of in vitro and in vivo studies of the synthesized compounds.
Online Conversation Monitoring to Understand the Opioid Epidemic: Epidemiological Surveillance Study
Authors: Black Joshua C , Margolin Zachary R , Olson Richard A , Dart Richard C 
Published: June 2020

BackgroundBetween 2016 and 2017, the national mortality rate involving opioids continued its escalation; opioid deaths rose from 42,249 to 47,600, bringing the public health crisis to a new height. Considering that 69% of adults in the United States use online social media sites, a resource that builds a more complete understanding of prescription drug misuse and abuse could supplement traditional surveillance instruments. The Food and Drug Administration has identified 5 key risks and consequences of opioid drugs—misuse, abuse, addiction, overdose, and death. Identifying posts that discuss these key risks could lead to novel information that is not typically captured by traditional surveillance systems.ObjectiveThe goal of this study was to describe the trends of online posts (frequency over time) involving abuse, misuse, addiction, overdose, and death in the United States and to describe the types of websites that host these discussions. Internet posts that mentioned fentanyl, hydrocodone, oxycodone, or oxymorphone were examined.MethodsPosts that did not refer to personal experiences were removed, after which 3.1 million posts remained. A stratified sample of 61,000 was selected. Unstructured data were classified into 5 key risks by manually coding for key outcomes of misuse, abuse, addiction, overdose, and death. Sampling probabilities of the coded posts were used to estimate the total post volume for each key risk.ResultsAddiction and misuse were the two most commonly discussed key risks for hydrocodone, oxycodone, and oxymorphone. For fentanyl, overdose and death were the most discussed key risks. Fentanyl had the highest estimated number of misuse-, overdose-, and death-related mentions (41,808, 42,659, and 94,169, respectively). Oxycodone had the highest estimated number of abuse- and addiction-related mentions (3548 and 12,679, respectively). The estimated volume of online posts for fentanyl increased by more than 10-fold in late 2017 and 2018. The odds of discussing fentanyl overdose (odds ratios [OR] 4.32, 95% CI 2.43-7.66) and death (OR 5.05, 95% CI 3.10-8.21) were higher for social media, while the odds of discussing fentanyl abuse (OR 0.10, 95% CI 0.04-0.22) and addiction (OR 0.24, 95% CI 0.15-0.38) were higher for blogs and forums.ConclusionsOf the 5 FDA-defined key risks, fentanyl overdose and death has dominated discussion in recent years, while discussion of oxycodone, hydrocodone, and oxymorphone has decreased. As drug-related deaths continue to increase, an understanding of the motivations, circumstances, and consequences of drug abuse would assist in developing policy responses. Furthermore, content was notably different based on media origin, and studies that exclusively use either social media sites (such as Twitter) or blogs and forums could miss important content. This study sets out sustainable, ongoing methodology for surveilling internet postings regarding these drugs.
Localización de empresas usando lógica difusa: Estrategia para su posicionamiento
Authors: Flores Romero Martha Beatriz , Guerrero Dávalos Cuauhtémoc , González Santoyo Federico 
Published: June 2020

<p>Esta investigación, consiste en determinar la ubicación óptima en la certeza e incertidumbre de una empresa dedicada a la producción de derivados del aguacate en el Estado de Michoacán, para ello toma en consideración factores objetivos y subjetivos. En este estudio se usará como base la metodología propuesta por Brown y Gibsosn (1972)- (B y G), la misma es presentada en teoría clásica, además se hace el análisis en un ambiente de incertidumbre usando lógica difusa, este enfoque no se ha reportado en la literatura especializada para el tratamiento de la metodología de referencia. Para la obtención de información (datos) se incorpora a la metodología de (B y G) apoyada por un panel de 5 expertos. Los resultados obtenidos usando lógica difusa, son eficientes y eficaces, se obtiene la ubicación óptima en la comunidad de San Juan Nuevo Parangaricutiro. De lo anterior se tiene que la aplicación de (ByG) usando números borrosos triangulares (NBT) en el estudio de localización de empresas, en el estudio se obtiene información no proporcionada de origen que es muy valiosa para fortalecer la toma de decisiones y diseño e implantación de planes estratégicos de desarrollo empresarial.<strong></strong></p>
A SWOT ANALYSIS OF ONLINE ROOM RESERVATION IN HOTEL SECTORS. (A CASE STUDY IN BALI HSOVEREIGN HOTEL)
Authors: Sanjaya I Wayan Kiki , Arianty A.A. Ayu Suwi , Suwintari I Gusti Ayu Eka , Dewi I Gusti Ayu Melistyari 
Published: June 2020

The present study discusses a SWOT analysis of online reservation applied in HSovereign Hotel, Tuban, Bali. The hotel expects to obtain the easier and faster services in room reservation in hotel sectors by using internet media through online process (e-commerce). However, there are several challenges occur in practice as seen in HSovereign Hotel. As a result, the quality of thereservationservices is considered bad, not professional, and ultimately gives impact upon consumers’ satisfaction. Therefore, the problem that will be observed in the present study is how the advantages, disadvantages, opportunities and threats of e-commerce usage in HSovereign Hotel can be identified. A descriptive-qualitative research is the type of the present study. The data of the present studywere obtained from observation, interview, and documentation in order to find out the advantages, disadvantages, opportunities and threats of online reservation in H Sovereign Hotel. Furthermore, the theories used in the present study are: hotel, reservation, room online reservation, definition of e-commerce, and room occupancy rate. The data were presented in both analytical descriptive and narrative, and also supported by presenting tables, maps, and figures. Based on the result of analysis, the advantages of e-commerce usage in online reservation services which attracted more residents to come is the effectiveness of online reservation system in H Sovereign Hotel. On contrary, the disadvantages of online reservation relies on its dependency oninternet connection and server system in H Sovereign Hotel. The opportunity can be identified from using online reservation is it could be a media promotion which enables consumers to reserve in the last minute, and the threats found are cancellations ensue and fake bookings that extremely threaten information system of room reservation in H Sovereign Hotel.
Efek Larvasida Fraksi Etil Asetat Daun Bangun-bangun (Plectranthus amboinicus) terhadap Mortalitas Larva Aedes aegypti
Authors: Sogandi Sogandi , Gunarto Fadhli 
Published: June 2020

Abstract. Mosquitoes are insects that can transmit diseases to humans through their bites. Dengue haemorrhagic fever is one of the diseases that could be transmitted by Aedes aegypti mosquito. The use of insecticides to control the occurrence of dengue haemorrhagic fever builds resistance of the mosquito towards the chemical substance. Therefore, natural larvicide was used as an alternative to chemical insecticides. This research was conducted to study the effectiveness of larvicides from the ethyl acetate fraction of Bangun-bangun leaves (Plectranthus amboinicus) in killing the Aedes aegypti larvae and to identify the active larvicide compounds. This laboratory experiment research tested six extract concentrations (0.0; 1.0; 1.8; 3.2; 5.6; 10.0%) in three replications. Observations were administered for 48 hours to count the number of the dead Aedes aegypti instar III larvae obtained from the Entomology Laboratory of the Faculty of Veterinary, IPB. The results showed that the larvae mortality increased as the extract concentration increased. The percentage of Aedes aegypti killed reached 96% at an extract concentration of 10%. Meanwhile, the probit analysis showed that LC50 was found at a concentration of 5.56%. The identification of active compounds using GCMS revealed that the larvicidal compounds in ethyl acetate fraction were the ones from an organic acid group which were, stearic acid, and palmitic acid.
Keywords: Aedes aegypti, identification, larvacidal, mortality

Abstrak. Nyamuk merupakan serangga yang dapat menularkan penyakit melalui gigitannya. Salah satu penyakit yang ditularkan adalah demam berdarah dengue yang dibawa oleh nyamuk Aedes aegypti. Pengendalian demam berdarah dengue menggunakan insektisida berbahan kimia dapat menyebabkan resisten nyamuk terhadap insektisida meningkat, oleh karena itu larvasida alami diharapkan dapat menjadi alternatif pengganti insektisida kimia. Tujuan dari penelitian ini adalah mengetahui afektifitas larvasida dari fraksi etil asetat daun Bangun-bangun (Plectranthus amboinicus) terhadap mortalitas larva Aedes aegypti dan mengidentifikasi jenis senyawa aktif yang berperan sebagai larvasida. Penelitian ini merupakan eksperimen laboratorium dengan enam konsentrasi ekstrak (0,0; 1,0; 1,8; 3,2; 5,6; 10,0%) dan tiga kali ulangan. Pengamatan dilakukan selama 48 jam terhadap jumlah kematian larva Aedes aegypti instar III yang diperoleh dari Laboratorium Entomologi Fakultas Kedokteran Hewan, IPB. Hasil penelitian menunjukkan bahwa kematian larva meningkat seiring dengan meningkatnya konsentrasi ekstrak. Kematian Aedes aegypti mencapai 96% pada konsentrasi ekstrak 10% dan hasil analisa probit menunjukkan LC50 terdapat pada konsentrasi 5,56%. Identifikasi senyawa aktif menggunakan GCMS menunjukkan bahwa senyawa yang bersifat larvasida dalam fraksi etil asetat ini adalah senyawa dari golongan asam organik yaitu, asam stearate, dan asam palmitat.
Kata Kunci: Aedes aegypti, identifikasi, larvasida, mortalitas
Fibrin coating of polymer vascular graft does not reduce its thromboresistance
Authors: Velikanova E. A. , Glushkova T. V. , Akentyeva T. N. , Matveeva V. G. , Khanova M. Yu. , Krivkina E. O. , Kudryavtseva Yu. A. , Antonova L. V. 
Published: June 2020

Aim. To evaluate biocompatibility along with adhesion and aggregation of platelets on the surface of uncoated and fibrin-coated poly(3-hydroxybutyrate- co-3-hydroxyvalerate)/poly(ε-caprolactone) (PHBV/PCL) small-diameter vascular grafts.Materials and Methods. 4 mm diameter grafts were fabricated by electrospinning from PHBV/ PCL (1:2) blend dissolved in 1,1,1,3,3,3-hexafluoro- 2-propanol. Inner wall of the grafts was produced using co-electrospinning of the polymer blend and collagen type I (5 mg/mL) from two different syringes. Fibrinogen was obtained from the blood of healthy donors by a cryoprecipitation procedure. Sterile polymer scaffolds were impregnated into a fibrinogen solution and immersed in a thrombin/calcium chloride blend for polymerization. To assess the biocompatibility of the grafts, primary human coronary artery endothelial cells were seeded on the luminal surface and counted under a fluorescence microscope after nuclear staining. Hemocompatibility was tested by incubation of the grafts with human platelet-rich plasma. Platelet aggregation was assessed using a platelet aggregation analyser. Surface morphology, platelet adhesion and activation were evaluated by scanning electron microscopy.Results. Fibrin coating promoted cell adhesion and proliferation and improved the graft biocompatibility as evidenced by a higher number of endothelial cells. Fibrin coating did not increase platelet aggregation, adhesion, and activation and therefore did not reduce the thromboresistance of vascular graft.Conclusion. The fibrin modification of polymer grafts from PHBV/PCL blend and collagen type I improves the surface biocompatibility and does not reduce its thromboresistance.
Annual personalised calculator for prognostication after ST-segment elevation myocardial infarction
Authors: Barbarich V. B. , Lozhkina N. G. , Tolmacheva A. A. , Hasanova M. H. , Stafeeva E. A. , Mukaramov I. , Parhomenko O. M. , Kuimov A. D. , Voskobojnikov Ju. E. 
Published: June 2020

Aim. To create a calculator for the annual personalised risk assessment of adverse cardiovascular events in patients after acute ST-segment elevation myocardial infarction (STEMI).Materials and Methods. Here we performed a prospective data analysis of 1,000 patients diagnosed with STEMI during 2017 and 2018 and admitted to Regional Vascular Center. For evaluating the risk of adverse cardiovascular events after STEMI, we applied the GRACE scale. After 1 year of follow-up, the predicted outcomes were compared with the actual outcomes. We then created a personalised calculator of unfavorable outcome by using logistic regression.Results. The calculator included six indicators that significantly correlated with outcomes and poorly correlated with each other: left ventricular ejection fraction (LVEF) < 40%, anterior STEMI, tachycardia upon admission, fasting blood glucose, high-sensitive C-reactive protein (CRP), and patient age.Conclusion. We found a high reliability of our calculator for the annual personalised prognosis of adverse outcome in patients after STEMI.
Age-related hypogonadism and cardiovascular disease risk
Authors: Lebedeva N. B. , Gofman V. V. 
Published: June 2020

Aim. To study the relationship between age-related androgen deficiency and the level of cardiovascular risk in healthy middle-aged men.Materials and Methods. We enrolled 200 men of 44-55 (median 48.44, interquartile range 45.02- 52.50) years who underwent a routine medical examination, having additionally measured age-related androgen deficiency.Results. A decrease in total testosterone of < 12.1 nmol/L indicative of age-related hypogonadism was detected in 98 (49.0%) men. In 42 (42.8%) men, a decrease in total testosterone was accompanied by loss of libido and erectile dysfunction. Relatively high prevalence of lipid metabolism disorders and subclinical atherosclerosis was diagnosed in men without established cardiovascular disease. Analysis according to the SCORE scale showed a predominance of patients with moderately increased risk, with only a small number of high-risk patients. Notably, all high-risk cases were identified in the age-related hypogonadism group. The distribution of cardiovascular risk score significantly differed in groups with and without age-related androgen deficiency.Conclusion. We demonstrate a relatively high prevalence of age-related testosterone deficiency, which is also associated with increased cardiovascular risk, among healthy middle-aged men.
Epidemiology and treatment of perforated duodenal ulcer in Kemerovo Region
Authors: Podoluzhnyi V. I. , Startsev A. B. , Radionov I. A. 
Published: June 2020

Aim.To estimate the frequency of ulcerative bleeding, pyloric stenosis, need for pyloroplasty and the justification of vagotomy for perforated duodenal ulcer.Materials and Methods.We analyzed the surgical treatment of patients with perforated duodenal ulcer admitted to Podgorbunskiy Regional Clinical Emergency Hospital during 1999-2019.Results.In 2018, the number of surgical interventions due to perforated duodenal ulcer decreased by 56.4% in comparison with 1998. In 8.6% and 2.1% of patients, perforated duodenal ulcer was combined with pyloric stenosis and bleeding, respectively, requiring Judd pyloroplasty (diamond- shaped transverse excision) or gastroduodenotomy followed by Heineke-Mikulicz pyloroplasty (transversely closed longitudinal incision across the pylorus) and vagotomy. Distal gastric resection by Billroth’s operation II was required in 2.8% of patients. Repeated admission of patients with duodenal ulcer complications has been observed after isolated suturing of perforated duodenal ulcer.Conclusion.Over the last 20 years, the amount of surgical interventions because of perforated duodenal ulcer in Kemerovo Region decreased more than twofold. In > 10% patients, pyloric stenosis and bleeding require a gastric drainage. In > 8% patients, perforated duodenal ulcer is combined with pyloric stenosis; in these cases, Heineke-Mikulicz pyloroplasty may be a treatment of choice. In > 2% patients, perforated duodenal ulcer is combined with ulcerative bleeding requiring excision of the ulcer and optional distal gastric resection. Pyloroplasty may be combined with vagotomy to normalise the proteolytic activity of gastric acid.