bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-life insights on menstrual cycles and ovulation using big data
Authors: Soumpasis I , Grace B , Johnson S 
Published: February 2020

Abstract

STUDY QUESTION
What variations underlie the menstrual cycle length and ovulation day of women trying to conceive?

SUMMARY ANSWER
Big data from a connected ovulation test revealed the extent of variation in menstrual cycle length and ovulation day in women trying to conceive.

WHAT IS KNOWN ALREADY
Timing intercourse to coincide with the fertile period of a woman maximises the chances of conception. The day of ovulation varies on an inter- and intra-individual level.

STUDY DESIGN, SIZE, DURATION
A total of 32 595 women who had purchased a connected ovulation test system contributed 75 981 cycles for analysis. Day of ovulation was determined from the fertility test results. The connected home ovulation test system enables users to identify their fertile phase. The app benefits users by enabling them to understand their personal fertility information. During each menstrual cycle, users input their perceived cycle length into an accessory application, and data on hormone levels from the tests are uploaded to the application and stored in an anonymised cloud database. This study compared users’ perceived cycle characteristics with actual cycle characteristics. The perceived and actual cycle length information was analysed to provide population ranges.

PARTICIPANTS/MATERIALS, SETTING, METHODS
This study analysed data from the at-home use of a commercially available connected home ovulation test by women across the USA and UK.

MAIN RESULTS AND THE ROLE OF CHANCE
Overall, 25.3% of users selected a 28-day cycle as their perceived cycle length; however, only 12.4% of users actually had a 28-day cycle. Most women (87%) had actual menstrual cycle lengths between 23 and 35 days, with a normal distribution centred on day 28, and over half of the users (52%) had cycles that varied by 5 days or more. There was a 10-day spread of observed ovulation days for a 28-day cycle, with the most common day of ovulation being Day 15. Similar variation was observed for all cycle lengths examined. For users who conducted a test on every day requested by the app, a luteinising hormone (LH) surge was detected in 97.9% of cycles.

LIMITATIONS, REASONS FOR CAUTION
Data were from a self-selected population of women who were prepared to purchase a commercially available product to aid conception and so may not fully represent the wider population. No corresponding demographic data were collected with the cycle information.

WIDER IMPLICATIONS OF THE FINDINGS
Using big data has provided more personalised insights into women’s fertility; this could enable women trying to conceive to better time intercourse, increasing the likelihood of conception.

STUDY FUNDING/COMPETING INTERESTS
The study was funded by SPD Development Company Ltd (Bedford, UK), a fully owned subsidiary of SPD Swiss Precision Diagnostics GmbH (Geneva, Switzerland). I.S., B.G. and S.J. are employees of the SPD Development Company Ltd.
V-REP-based navigation of automated wheeled robot between obstacles using PSO-tuned feedforward neural network
Authors: Pandey Anish , Panwar Vikas Singh , Hasan Md Ehtesham , Parhi Dayal R 
Published: February 2020

Abstract
This paper describes the navigation of an automated Pioneer P3-DX wheeled robot between obstacles using particle swarm optimization (PSO) algorithm tuned feedforward neural network (FNN). This PSO algorithm minimizes the mean square error between the actual and predicted values of the FNN. In this work, 2 separate DC motors and 16 ultrasonic sensors have been used for making differential drive steering angle and for collecting the distance from obstacles, respectively. The proposed without tuned FNN and PSO-tuned FNN receives obstacle's distance as inputs form ultrasonic sensors and control the steering angle of a differential drive of automated Pioneer P3-DX wheeled robot as output. We have compared the results between without tuned FNN and PSO-tuned FNN, and it has been found that PSO-tuned FNN gives a better trajectory and takes less distance to reach the target. Virtual Robot Experimentation Platform software has been used to design the real-time simulation results. A comparative study between without tuned FNN and PSO-tuned FNN verifies the effectiveness of PSO-tuned FNN for automated Pioneer P3-DX wheeled robot navigation. Also, we have compared this winner PSO-tuned FNN to the previously developed PSO-optimized Fuzzy Logic Controller navigational technique to show the authenticity and real-time implementation of PSO-tuned FNN.
Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results from standardin vitrogenotoxicity assays
Authors: Pfuhler Stefan , Pirow Ralph , Downs Thomas R , Haase Andrea , Hewitt Nicola , Luch Andreas , Merkel Marion , Petrick Claudia , Said André , Schäfer-Korting Monika , Reisinger Kerstin 
Published: February 2020

AbstractAs part of the safety assessment process, all industrial sectors employ genotoxicity test batteries, starting with well-established in vitro assays. However, these batteries have limited predictive capacity for the in vivo situation, which may result in unnecessary follow-up in vivo testing or the loss of promising substances where animal tests are prohibited or not desired. To address this, a project involving regulators, academia and industry was established to develop and validate in vitro human skin-based genotoxicity assays for topically exposed substances, such as cosmetics ingredients. Here, we describe the validation of the 3D reconstructed skin (RS) Comet assay. In this multicenter study, chemicals were applied topically three times to the skin over 48 h. Isolated keratinocytes and fibroblasts were transferred to slides before electrophoresis and the resulting comet formation was recorded as % tail DNA. Before decoding, results of the validation exercise for 32 substances were evaluated by an independent statistician. There was a high predictive capacity of this assay when compared to in vivo outcomes, with a sensitivity of 77 (80)%, a specificity of 88 (97)% and an overall accuracy of 83 (92)%. The numbers reflect the calls of the performing laboratories in the coded phase, whereas those in parenthesis reflect calls according to the agreed evaluation criteria. Intra- and inter-laboratory reproducibility was also very good, with a concordance of 93 and 88%, respectively. These results generated with the Phenion® Full-Thickness skin model demonstrate its suitability for this assay, with reproducibly low background DNA damage and sufficient metabolic capacity to activate pro-mutagens. The validation outcome supports the use of the RS Comet assay to follow up positive results from standard in vitro genotoxicity assays when the expected route of exposure is dermal. Based on the available data, the assay was accepted recently into the OECD test guideline development program.
A rare coexistence of Behcet’s disease and Graves’ thyrotoxicosis in a young man: a case report
Authors: Joshi Hareesh , Shahriar Imran , Sharma Poonam , Sagi Satyanarayana V , Oyibo Samson O 
Published: February 2020

Abstract
Behcet’s disease is a recurrent systemic vasculitic disorder. It manifests most commonly in the form of skin lesions, oral and genital ulcers and uveitis. Graves’ thyrotoxicosis is an autoimmune disorder characterized by excessive production of thyroid hormones. We present a case of a 41-year-old male of Turkish descent who had symptoms of arthralgia, rash, palpitations and weight loss. Bloods tests showed raised inflammatory markers and biochemical evidence of severe autoimmune thyrotoxicosis. The patient was HLA-B51-negative, and pathergy test was inconclusive. A diagnosis of Behcet’s disease was made on constellation of clinical symptoms. The patient was treated with carbimazole and prednisolone followed by azathioprine. The coexistence of Behcet’s disease and Graves’ disease in the same patient is very rare. Further studies are required to determine if there is a pathological association between these two conditions.
Famotidine induced hypomagnesemia leading to hypocalcemia
Authors: Essrani Rajesh , Mehershahi Shehriyar , Ravi Shri Jai Kirshan , Essrani Rajesh Kumar , Sudhakaran Anuraj , Hossain Muhammad , Yang Tsu Jung , Mehmood Asif 
Published: February 2020

Abstract
Fifty-five-year-old female with a past medical history of gastroesophageal reflux disease was admitted to hospital due to increased confusion, and muscle cramps for last 15 days. She was taking famotidine 20 mg twice a day for the last 2 years. She was alert and oriented to person and place only. She had dry skin, positive Chvostek’s and Trousseau’s sign. Blood work showed 141 mmol/L of sodium, 0.7 mg/dl of creatinine, 5.7 mg/dl of calcium, 0.55 mg/dl of magnesium, low PTH but normal parathyroid related peptide PTHrP, vitamin D (25) and vitamin D (1.25). She was discharged home on electrolyte supplements. She was readmitted with very low calcium and magnesium. Extensive workup including 24 h of urine calcium and magnesium was unimpressive. She was treated with IV therapy and discharged to follow up with nephrology in the clinic, and famotidine was discontinued on second discharge. Her calcium and magnesium levels remained normal, and in a few weeks later, oral electrolyte supplements were discontinued.
Response to anti-PD1 immunotherapy in patients with metastatic cutaneous sarcoma: case reports and literature review
Authors: Vieira Aline Cristini , Megid Thais Baccili Cury , Melo Raissa , Muniz David , Salgues Alessandra Corte Real , Barbosa Felipe Galiza , Munhoz Rodrigo Ramella , Feher Olavo 
Published: February 2020

Abstract
Dermal sarcomas represent a group or rare malignancies of mesenchymal origin. Although surgical excision with wide margins can be curative, in the advanced/metastatic setting, treatment options are limited and the benefit from anthracycline-based chemotherapy or targeted agents is usually short-lived. Tumor mutational burden and PD-L1 expression scores can be used as predictive biomarker for response to immunotherapy in some metastatic cancers. The role of immune-checkpoint blockade for sarcoma patients remains investigational. Here we present three cases of dermal sarcomas with high TMB and PD-L1 expression and responses to anti-PD1 agents in two of them.
Autonomy, Integrity, and Values in Public Administration: A Dilemma and a Case
Authors: Seibel Wolfgang 
Published: February 2020

Abstract
This article addresses a classic problem of public administration, which is the quest for institutional integrity in the presence of bureaucratic autonomy. It does so in combination with a history of ideas account of the subject with a case study of derailed autonomy at the expense of institutional integrity It does so in combination with a history of ideas account of the subject with a case study of derailed autonomy at the expense of institutional integrity with particularly serious consequences in the form of human casualties. Referring to literature on public values and moral hazard under the condition of bureaucratic discretion, the article argues that harmonizing bureaucratic autonomy and institutional integrity requires commitment to public values that prioritize the protection of basic individual rights over temptations of pragmatic decision making. It is, therefore, a plea for linking traditional lines of thoughts on public administration with a more fine-grained assessment of the ambivalence of governmental agencies as both guardians of, and a menace to, rule-of-law-based protection of civic values.
Phase transition and geometrical thermodynamics of energy-dependent dilatonic BTZ black holes with power-law electrodynamics
Authors: Dehghani M , Badpa M 
Published: February 2020

Abstract
The coupled scalar, electromagnetic, and gravitational field equations of Einstein–dilaton gravity theory have been solved in a three-dimensional energy-dependent spacetime and in the presence of power-law nonlinear electrodynamics. The scalar potential is written as the linear combination of two exponential functions, and two families of three-dimensional dilatonic black hole solutions have been introduced which indicate the impacts of rainbow functions on the spacetime geometry. Through consideration of curvature scalars, it has been found that the asymptotic behavior of the solutions is neither flat nor anti-de Sitter. It has been illustrated that, with a suitable choice of parameters, the solutions can produce the two-horizon, extreme and naked singularity black holes. By calculating the black hole charge, mass, entropy, temperature, and electric potential, it has been proved that they fulfill the standard form of the first law of black hole thermodynamics. The thermodynamic stability of the black holes has been analyzed by utilizing the canonical and grand canonical ensembles and noting the signature of the black hole heat capacity and Gibbs free energy of the black holes. The points of type-1, type-2, and Hawking–Page phase transitions and the ranges at which the black holes are locally or globally stable have been determined. The geometrical thermodynamics of the black holes has been studied by use of different thermodynamic metrics, and the results of different approaches have been compared.
Waring’s Problem for Rational Functions in One Variable
Authors: Im Bo-Hae , Larsen Michael 
Published: February 2020

Abstract
Let $f\in{\mathbb{Q}}(x)$ be a non-constant rational function. We consider ‘Waring’s problem for $f(x)$,’ i.e., whether every element of ${\mathbb{Q}}$ can be written as a bounded sum of elements of $\{f(a)\mid a\in{\mathbb{Q}}\}$. For rational functions of degree $2$, we give necessary and sufficient conditions. For higher degrees, we prove that every polynomial of odd degree and every odd Laurent polynomial satisfies Waring’s problem. We also consider the ‘easier Waring’s problem’: whether every element of ${\mathbb{Q}}$ can be represented as a bounded sum of elements of $\{\pm f(a)\mid a\in{\mathbb{Q}}\}$.
Case Report: Optical Coherence Tomography Angiography of Idiopathic Foveal Hypoplasia and Its Correlation With Visual Acuity
Authors: Lypka Karin Rose , Rodman Julie , Starman Kelsey , Woods Albert David , Bi Hua 
Published: February 2020

SIGNIFICANCE
Foveal hypoplasia is described clinically by the absence of a foveal pit and subsequent reduction in visual acuity. Optical coherence tomography angiography provides precise segmentation of the retinal vascular supply demonstrating the vascular perfusion in affected patients. Preservation of perfusion is linked to visual acuity and function.

PURPOSE
This case report describes a patient with foveal hypoplasia and preservation of visual acuity with preserved retinal capillary density of the superficial and deep capillary plexuses on optical coherence tomography angiography. In addition, the diagnostic findings of foveal hypoplasia as seen on optical coherence tomography angiography will be described.

CASE REPORT
A 25-year-old Caucasian female with history of foveal hypoplasia presented to the clinic for evaluation. She had no other visual, ocular, or systemic complaints. Her ocular history included Duane syndrome, accommodative insufficiency, and traumatic brain injury. Her medical history included cardiac ablation secondary to supraventricular tachycardia, gall bladder removal, maxillary sinus cyst, and a history of migraines. Best-corrected visual acuity was 20/15 in the right and left eyes. Funduscopic examination was unremarkable. Spectral domain optical coherence tomography revealed absence of the anatomical foveal pit with normal inner retinal morphology. Optical coherence tomography angiography confirmed a decreased foveal avascular zone; however, a vascular density analysis showed normal perfusion to the inner retinal plexuses.

CONCLUSIONS
Optical coherence tomography angiography is a rapid, noninvasive imaging modality that provides excellent insight into the microvasculature supply to the retina and choroid. As such, it allows for an in-depth analysis into the pathophysiology behind certain conditions such as foveal hypoplasia.
Case Report: Glaucoma-associated Peripapillary Retinoschisis with Corresponding Lamina Cribrosa Defect
Authors: Roberts Justin D. , Hunter Amanda , Mega Joseph , Cesaro Thomas , Greenberg Paul B. 
Published: February 2020

SIGNIFICANCE
Peripapillary retinoschisis is associated with primary and secondary glaucoma. It is important that clinicians are familiar with the presentation and management of peripapillary retinoschisis to understand its effects on the patient's glaucoma and to avoid unnecessary referral when the macula is not involved.

PURPOSE
We present a case of peripapillary retinoschisis found incidentally on routine optical coherence tomographic (OCT) surveillance of primary open-angle glaucoma.

CASE REPORT
A 70-year-old man presented for his annual diabetic eye examination. Surveillance with OCT revealed a splitting of the inner peripapillary retina corresponding to a previously noted notch in the right optic nerve. Further imaging of the right eye using enhanced depth imaging OCT revealed a defect in the lamina cribrosa that may have contributed to the formation and persistence of peripapillary retinoschisis. Retinal nerve fiber layer analysis showed a 5-year history of progressive temporal and inferotemporal thickening in the right eye. The patient was managed conservatively with instruction on regular Amsler grid testing.

CONCLUSIONS
As seen in this case, peripapillary retinoschisis typically alters retinal nerve fiber layer thickness on OCT and can be mistakenly attributed to glaucomatous change. Glaucoma-associated peripapillary retinoschisis is usually not vision threatening and can be managed conservatively; in rare cases of progression to macular involvement, patients should be referred to a retina specialist.
Using Anterior Segment Optical Coherence Tomography to Assess Angle Anatomy in Patients with Neurofibromatosis Type 1
Authors: Duru Zeynep , Altunel Orhan 
Published: February 2020

SIGNIFICANCE
Lisch nodules have been identified in more than 90% of patients 16 years or older with neurofibromatosis type 1 (NF1). According to our hypothesis, the presence of Lisch nodules in patients with NF1 might affect the anterior chamber angle (ACA) parameters.

PURPOSE
The aim of this study was to evaluate the anterior segment angle parameters using anterior segment optical coherence tomography in patients with NF1.

METHODS
A total of 42 eyes from 21 patients with NF1 (study group) and 42 eyes from 21 age- and sex-matched healthy individuals (control group) were included in this study. Angle opening distance at 500 (AOD500) and 750 μm (AOD750) anterior to the scleral spur, ACA, and iris thickness (IT) values were measured in the temporal (T) and nasal (N) quadrants using anterior segment optical coherence tomography.

RESULTS
The mean AOD500 and AOD750 values in both quadrants were significantly lower in the study group compared with the control group (T-AOD500: 548 ± 151 vs. 761 ± 288 [P < .001], T-AOD750: 705 ± 175 vs. 921 ± 334 [P < .001], N-AOD500: 599 ± 223 vs. 777 ± 292 [P = .002], and N-AOD750: 756 ± 268 vs. 948 ± 303 [P = .003], respectively). The mean ACA values in both quadrants were significantly narrower in the study group compared with the control group (T-ACA: 29.52 ± 6.36 vs. 40.83 ± 8.90 [P < .001] and N-ACA: 30.05 ± 7.11 vs. 41.29 ± 8.68 [P < .001], respectively). The IT values in both quadrants were significantly thicker compared with the control group (T-IT500: 406 ± 78 vs. 355 ± 59 [P = .001], T-IT750: 453 ± 103 vs. 362 ± 100 [P < .001], N-IT500: 416 ± 93 vs. 353 ± 54 [P < .001], and N-IT750: 437 ± 91 vs. 370 ± 95 [P = .002], respectively).

CONCLUSIONS
We have revealed lower angle opening distance values in individuals with NF1 than in the healthy ones, as well as significantly narrower ACA values and significantly thicker IT values.
Design of water harvesting towers and projections for water collection from fog and condensation
Authors: Bhushan Bharat 
Published: February 2020

Fresh water sustains human life and is vital for human health. It is estimated that about 800 million people worldwide lack basic access to drinking water. About 2.2 billion people (nearly one-third of the global population) do not have access to a safe water supply, free of contamination. Also, over 2 billion people live in countries experiencing high water stress. Current supply of fresh water needs to be supplemented to meet future needs. Living nature has evolved species which can survive in the most arid regions of the world by water collection from fog and condensation in the night. Before the collected water evaporates, species have mechanisms to transport water for storage or consumption. These species possess unique chemistry and structures on or within the body for collection and transport of water. In this paper, an overview of arid desert conditions, water sources and plants and animals, lessons from nature for water harvesting, and water harvesting data from fog and condensation are presented. Consumer, emergency and defence applications are discussed and various designs of water harvesting towers and projections for water collection are presented.
This article is part of the theme issue ‘Bioinspired materials and surfaces for green science and technology (part 3)’
Clustering and self-organization in small-scale natural and artificial systems
Authors: Bormashenko Edward , Fedorets Alexander A. , Frenkel Mark , Dombrovsky Leonid A. , Nosonovsky Michael 
Published: February 2020

Physical properties of clusters, i.e. systems composed of a ‘small’ number of particles, are qualitatively different from those of infinite systems. The general approach to the problem of clustering is suggested. Clusters, as they are seen in the graphs theory, are discussed. Various physical mechanisms of clustering are reviewed. Dimensional properties of clusters are addressed. The dimensionality of clusters governs to a great extent their properties. Weakly and strongly coupled clusters are discussed. Hydrodynamic and capillary interactions giving rise to clusters formation are surveyed. Levitating droplet clusters, turbulent clusters and droplet clusters responsible for the breath-figures self-assembly are considered. Entropy factors influencing clustering are considered. Clustering in biological systems results in non-equilibrium multi-scale assembly, where at each scale, self-driven components come together by consuming energy in order to form the hierarchical structure.
This article is part of the theme issue ‘Bioinspired materials and surfaces for green science and technology (part 3)’.