bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology
Authors: Szweda Marta , Rychlik Andrzej , Babińska Izabella , Pomianowski Andrzej 
Published: May 2020

Abstract
In canine and feline populations, the number of neoplasm cases continues to increase around the world. Attempts are being made in centres of research to identify new biomarkers that speed up and improve the quality of oncological diagnostics and therapy in human and animal tumour patients. Cyclooxygenase-2 (COX-2) is a promising biomarker with increasing relevance to human oncology, but as yet with less application in veterinary oncology. The expression of COX-2 increases significantly during pathological processes involving inflammation, pain or fever. It is also overexpressed in humans presenting various types of tumours and in selected types of tumours in animals, particularly in dogs. This article discusses the expression of COX-2 in canine and feline tumours, the importance of COX-2 as a biomarker with diagnostic, therapeutic, prognostic and predictive relevance in oncology, and the clinical significance of inhibiting COX-2 overexpression in tumours.
Parasitological monitoring of European bison (Bison bonasus) from three forests of north-eastern Poland between 2014 and 2016
Authors: Krzysiak Michał K. , Demiaszkiewicz Aleksander W. , Larska Magdalena , Tomana Jarosław , Anusz Krzysztof 
Published: May 2020

Abstract

Introduction
Common parasites of the European bison include gastro-intestinal and pulmonary nematodes, liver flukes (Fasciola hepatica), tapeworms, and protozoa of the genus Coccidia. This study compared the extensiveness and intensities of European bison parasitic invasions in three north-eastern Polish forests in different seasons and queried the role of parasitological monitoring in sanitary and hygienic control of feeding places.

Material and Methods
Faecal samples were collected in the Białowieża, Knyszyńska, and Borecka Forests between 2014 and 2016, as were some from an area neighbouring the Białowieża Forest outside the Natura 2000 protected area. Parasites were detected in individual samples with the flotation, decanting and Baermann methods.

Results
The eggs of Trichostrongylidae, Aonchotheca sp., Nematodirus sp., Strongyloides spp., Trichuris sp., Moniezia spp., and Fasciola hepatica; the larvae of Dictyocaulus viviparus; and the oocytes of Eimeria spp. were identified. Significant variation in invasion intensity and diversity was seen by origin and season. The relationships were assessed first by univariable tests and next multivariately, when origin and season emerged as the major risk factors for exposure to most of the parasites.

Conclusion
The differences in the level of parasitic infection between the forests did not have implications for its sufficiency to cause clinical symptoms. However, the associations and risk factors found enable the necessary preventive measures to be taken to protect the E. bison from exposure or decrease the risks. Additionally, parasitological monitoring is appropriate as the method of sanitary and hygienic control of European bison winter feeding places. Threats to public health through adventitious invasions by zoonotic factors such as F. hepatica have been identified.
Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway
Authors: Luo Yi-Ran , Zhou Shu-Ting , Yang Liang , Liu Yuan-Ping , Jiang Sheng-Yao , Dawuli Yeliboli , Hou Yi-Xuan , Zhou Tian-Xing , Yang Zhi-Biao 
Published: May 2020

Abstract

Introduction
Porcine epidemic diarrhoea virus (PEDV) infection causes watery diarrhoea, vomiting, anorexia, and weight loss, especially among neonatal piglets, inflicting on them morbidity and mortality potentially reaching 90%–100%. Despite it being known that certain mammalian cell phases are arrested by PEDV, the mechanisms have not been elucidated, and PEDV pathogenesis is poorly understood. This study determined the effect of an epidemic PEDV strain on cell cycle progression.

Material and Methods
We observed the effect of the PEDV SHpd/2012 strain on an infected Vero cell cycle through flow cytometry and Western blot, investigating the interrelationships of cell-cycle arrest, the DNA damage–signalling pathway caused by PEDV and the phosphorylation levels of the key molecules Chk.2 and H2A.X involved upstream and downstream in this pathway.

Results
PEDV induced Vero cell-cycle arrest at the G1/G0 phase. The phosphorylation levels of Chk.2 and H2A.X increased with the prolongation of PEDV infection, and no significant cell-cycle arrest was observed after treatment with ATM or Chk.2 inhibitors. The proliferation of PEDV was also inhibited by treatment with ATM or Chk.2 inhibitors.

Conclusion
PEDV-induced cell-cycle arrest is associated with activation of DNA damage–signalling pathways. Our findings elucidate the molecular basis of PEDV replication and provide evidence to support further evaluation of PEDV pathogenesis.
Negation Polarizes Agreement Dynamics During Sentence Comprehension
Authors: Huette Stephanie 
Published: May 2020

Abstract
In a forced-choice mouse-tracking paradigm, true and false statements (ranging from very true, to ambiguous, to very false) were tested in both affirmative and negated forms. Replicating prior research, mouse trajectories reveal subtle differences in a continuum of true to false statements. However, negation modifies this process, particularly for very true statements (i.e. Bread is not made from sand). The mouse trajectories were more curved with negated sentences, with end-points of the continuum of truth (very true and very false statements) having the greatest area under the curve. The proposed explanation is the pragmatic meaning of a negated statement such as “Gummie bears are not alive” is infelicitous, whereas a true statement “People live on Earth” is felicitous. This study reveals the online dynamics of processing these statements and possible confusion, particularly when very true statements contain a negation.
The Typology of Travels in Pristina in Relation to Purpose, Time and Distance
Authors: Humolli Fitim , Çinaj Nevila , Kelmendi Naim 
Published: May 2020

Abstract
Similar to most cities in Europe/the world, Kosovo also faces the problem of urban mobility, which is characterised by congestion. The most concerning problems are: waste of time, money, energy consumption, environmental problems and others. They arise due to the imbalanced state of using urban mobility in Pristina (Prishtinë), while eco-travels are minor. In order to reduce these problems, this paper aimed to examine the current situation of urban mobility in Pristina by analysing the mobility indicators of cars, trains, buses, bicycles and walking, in relation to purpose, distance and time. The research methodology was the direct survey method conducted with the citizens of Pristina and daily immigrants over a week. The results of the survey showed that 44% of the participants used cars for travelling, while other transportation alternatives (soft and eco-transport) were limited and problematic. In the absence of institutional practices for collecting periodic data, the results of this study will not only contribute in filling the information gap, but also will properly address the needs for transportation planning in Pristina and design objectives for a multimodal transportation strategy in this city to lessen the negative impacts of the aforementioned problems and increase travel facilities.
An Analysis of the Culinary Tourism Experience between Gender Groups in Iran
Authors: Movahed Ali , Ghasemi Moslem , Gholamalifard Nasrin 
Published: May 2020

Abstract
The purpose of this study is to investigate the role of culinary tourism experience between gender groups in Iranian culinary education tours. The research sample was randomly selected from 50 foreign tourists who participated in Persian Food Torus Institute’s culinary tours during four months. Kim et al. (2012) model of Memorable Tourism Experiences (MTEs) is used to design the research questionnaire and data. The results show that there is a significant difference in women’s desire for enjoyment, sense of freedom, power and refreshment rather than men. But in terms of novelty, local culture, meaningfulness, and knowledge gained for both men and women, it was no difference.
Spatial-Temporal Dynamics Land Use/Land Cover Change and Flood Hazard Mapping in the Upstream Citarum Watershed, West Java, Indonesia
Authors: Yulianto Fajar , Suwarsono  , Nugroho Udhi Catur , Nugroho Nunung Puji , Sunarmodo Wismu , Khomarudin Muhammad Rokhis 
Published: May 2020

Abstract
This study presents the information on the dynamics of changes in land use/land cover (LULC) spatially and temporally related to the causes of flooding in the study area. The dynamics of LULC changes have been derived based on the classification of Landsat imagery for the period between 1990 and 2016. Terrain surface classification (TSC) was proposed as a micro-landform classification approach in this study to create flood hazard assessment and mapping that was produced based on the integration of TSC with a probability map for flood inundation, and flood depth information derived from field observation. TSC as the micro-landform classification approach was derived from SRTM30 DEM data. Multi-temporal Sentinel-1 data were used to construct a pattern of historical inundation or past flooding in the study area and also to produce the flood probability map. The results of the study indicate that the proposed flood hazard mapping (FHM) from the TSC as a micro-landform classification approach has the same pattern with the results of the integration of historical inundation or previous floods, as well as field investigations in the study area. This research will remain an important benchmark for planners, policymakers and researchers regarding spatial planning in the study area. In addition, the results can provide important input for sustainable land use plans and strategies for mitigating flood hazards.
Significance of nuclear factor - kappa beta activation on prostate needle biopsy samples in the evaluation of Gleason score 6 prostatic carcinoma indolence
Authors: Zupancic Marko , Pospihalj Boris , Cerovic Snezana , Gazic Barbara , Drev Primoz , Hocevar Marko , Perhavec Andraz 
Published: May 2020

Abstract

Background
The goal of our study was to find out whether the immunohistochemical expression of nuclear factor-kappa beta (NF-κB) p65 in biopsy samples with Gleason score 3 + 3 = 6 (GS 6) can be a negative predictive factor for Prostate cancer (PCa) indolence.

Patients and methods
Study was conducted on a retrospective cohort of 123 PCa patients with initial total PSA ≤ 10 ng/ml, number of needle biopsy specimens ≥ 8, GS 6 on biopsy and T1/T2 estimated clinical stage who underwent laparoscopic radical prostatectomy and whose archived formalin-fixed and paraffin-embedded (FFPE) prostate needle biopsy specimens were used for additional immunohistochemistry staining for detection of NF-κB p65. Both cytoplasmic and nuclear NF-κB p65 expression in biopsy cores with PCa were correlated with postoperative pathological stage, positive surgical margins, GS and biochemical progression of disease.

Results
After follow-up of 66 months, biochemical progression (PSA ≥ 0.2 ng/ml) occurred in 6 (5.1%) patients, 3 (50%) with GS 6 and 3 (50%) with GS 7 after radical prostatectomy. Both cytoplasmic and nuclear NF-κB p65 expressions were not significantly associated with pathological stage, positive surgical margin and postoperative GS. Patients with positive cytoplasmic NF-kB reaction had significantly more frequent biochemical progression than those with negative cytoplasmic NF-kB reaction with PSA 0.2 ng/ml as cutoff point (p = 0.015) and a trend towards more biochemical progression with PSA ≥ 0.05 ng/ml as cutoff point (p = 0.068).

Conclusions
Cytoplasmic expression of NF-κB is associated with more biochemical progression and might be an independent prognostic factor for recurrence-free survival (RFS), but further studies including larger patient cohorts are needed to confirm these initial results.
Multi-objectives Optimal Scheduling in Smart Energy Hub System with Electrical and Thermal Responsive Loads
Authors: Chamandoust Heydar , Derakhshan Ghasem , Hakimi Seyed Mehdi , Bahramara Salah 
Published: May 2020

Abstract
In this study, multi-objective optimal scheduling of smart energy Hub system (SEHS) in the day ahead is proposed. A SEHS is comprising of interconnected energy hybrid system infrastructures such as electrical, thermal, wind, solar, natural gas and other fuels to supply many types of electrical and thermal loads in a two-way communication platform. All objectives in this paper, are minimized and consist of 1) operation cost and emission polluting in generation side, 2) loss of energy supply probability (LESP) in demand side, and 3) deviation of electrical and thermal loads with the optimal level of electrical and thermal profile in the day ahead. The third objective to flatten electrical and thermal demand profile using Demand Side Management (DSM) by the optimal shifting of electrical and thermal shiftable loads (SLs) is proposed. Also, stochastic modelling of renewable energy sources (RESs) and electrical and thermal loads by Monte Carlo technique is modelled. Using GAMS optimization software, proposed approach by ε -constraint method for obtaining to non-dominated Pareto solutions of objectives is implemented. Moreover, by the decision-making method, the best solution of non-dominated Pareto solutions is selected. Finally, two case studies and sensitivity analysis in case studies for confirmation of the proposed approach are analysed.
Do We Care about Going Green? Measuring the Effect of Green Environmental Awareness, Green Product Value and Environmental Attitude on Green Culture. An Insight from Nigeria
Authors: Ogiemwonyi Osarodion , Harun Amran Bin , Alam Mohammad Nurul , Othman Bestoon Abdulmaged 
Published: May 2020

Abstract
As the environment continues to aggravate, it has become a purposeful public concern in developed countries and has recently stirred developing countries to join the green movement. Hence, this study examines green environmental awareness, green product value and environmental attitude by applying the measurement of effects on green culture. The study applied a quantitative research approach where a cross-sectional survey designed with 267 respondents’ green consumer who lived in the urban area of Abuja and employed partial least squares structural equation modelling (PLS-SEM) using SmartPLS3 to examine the developed path model. The results indicated that all constructs were empirically supported showing significant impact on green culture while examining direct relationships. The resulting (Q2) value is larger than zero (0) in the path model, this specifies that exogenous constructs have a good index for predictive relevance on the endogenous construct being investigated. Among the construct, awareness is the most important predictor and green product value tends to show a modest impact on environmental attitude. The study suggests that policymakers should place emphasis on environmental values to boost environmental awareness among young consumers in the process of making purchases. Specifically, environmental attitude was found to have full mediation on the relationship between green product value and green culture. However, no mediation occurs in the relationship between environmental awareness and green culture. The study concluded that awareness regarding going green activism in Nigeria among young consumers is still a matter of concern despite its impact and therefore, practitioners and collaborators in the green industry need to apply aggressive efforts to achieve this pathway, to ensure the design and implementation of effective policies that will promote going green and enhance the green circular economy.
Geography of research on post-socialist cities: a bibliometric approach
Authors: Bajerski Artur 
Published: May 2020

AbstractThe main aim of the article is to investigate the spatial structure of international research on post-socialist cities. The analysis is based on data derived from the Scopus database (2001–2018) and includes issues such as the publication dynamics, structure of authors (with regard to cities and countries), main publishing ‘channels’, as well as networks in ‘producing’ knowledge on post-socialist cities. The analyses conducted primarily lead to a general conclusion about the high spatial concentration of these studies in the scientific centres of Central and Eastern Europe. On a more detailed dimension, however, analyses show a significant diversity in both the publication channels used by researchers and the co-citation networks. On this basis, a conclusion is made about the occurrence of the problem of introversions in research on post-socialist cities on an international scale, which is a broader concept than the Anglo-American dominance discussed for at least two decades.
Kehidupan Manusia Modern Awal di Indonesia: Sebuah Sintesa Awal
Authors: Simanjuntak Truman 
Published: May 2020

Abstract. The Life of Early Modern Human in Indonesia: A Preliminary Synthesis. The Late Pleistocene period or, in broader sense, the second half of the Upper Pleistocene, was in general related to the emergence and development of Early Modern Human (EMH) in Indonesia. Archaeological evidences have more or less confirmed their existence - with records of their unique behavior - within the period. In spite of the still obscure date of their initial occupation, the available radiometry dating reveals that this early Homo sapiens had inhabited Indonesia, and Southeast Asia in general, at least since ca. 45 kya up to the end of the Ice Age. Some of the most prominent behavior phenomena, which distinct modern human to early men's behavior who inhabited Indonesia since millions of years previously, are: (I) exploitation of wider geographical area within the archipelago; (2) change of activity orientation from open-air areas to natural niches, such as caves and rock shelters; (3) development of lithic technology that produced flake tools, replacing the chopper/chopping tool groups; and (4) more advanced and diverse systems of subsistence with more varied animals to hunt. The entire phenomena of behavior are the main focus of this paper. Abstrak. Rentang waktu Plestosen Akhir atau paruh kedua Plestosen Atas pada umumnya merupakan periode yang mengait dengan kemunculan dan perkembangan Manusia Modern Awal (MMA) di Indonesia. Bukti-bukti arkeologi sedikit banyaknya telah meyakinkan keberadaannya, berikut rekaman perilakunya yang khas, dalam periode tersebut. Terlepas dari pertanggalan kolonisasi awal yang belum diketahui pasti dari manusia modern awal ini, pertanggalan radiometri yang tersedia menampakkan bahwa mereka telah menghuni Indonesia, dan Asia Tenggara pada umumnya, paling tidak sejak sekitar 45 ribu tahun lalu hingga akhir kala Plestosen.Beberapa fenomena perilaku yang paling menonjol, yang membedakannya dari perilaku manusia purba yang mendiami Indonesia sejak jutaan tahun sebelumnya, adalah: (1) ekploitasi geografi yang semakin luas di kepulauan; (2) perubahan lokasi hunian dari bentang alam terbuka ke relung-relung alam seperti gua dan ceruk; (3) pengembangan teknologi litik yang menghasilkan alat-alat serpih menggantikan alat-alat yang tergolong kelompok kapak perimbas/penetak; dan (4) sistem mata pencaharian yang lebih maju dan beragam dengan eksploitasi lingkungan (flora dan fauna) yang lebih bervariasi. Keseluruhan fenomena perilaku tersebut akan menjadi pokok bahasan tulisan ini.
The Role of Bhima at Candi Sukuh: As Represented by a Number of Reliefs
Authors: Santiko Hariani 
Published: May 2020

Abstract. Bhima figure is represented in a number of reliefs at the complex of Candi Sukuh. It is found in the Bhimaswarga episodes depicted on the wall of Kyai Sukuh temple, a small temple in front of the main temple of Sukuh. A fragment of the same story is also depicted in a Kala-mrga arch. A fragment of the Sudamala illustrating Bhima s attacks on a demon, is depicted on a slab of stone, and another unidentified reliefs of Bhima scattered in the courtyard of Sukuh. From the comparative study of the artefactual data with the textual data, I presume that Bhima was worshipped as a mediator between god Siwa and men who wanted to get their final release (moksa). Bhima s role as the saviour of men is found in the story of Bhimaswarga. In the final episode of Bhimaswarga-reliefs, Bhima is given a bottle of amrta by Siwa. Abstrak. Peranan Bhima di Candi Sukuh. Tokoh Bhima digambarkan dalam sejumlah relief di Kompleks Percandian Sukuh. Tokoh ini dijumpai pada episode-episode ceritera Bhimaswarga yang dipahatkan pada dinding Candi Kyai Sukuh, yaitu sebuah kuil kecil di muka kuil utama Candi Sukuh. Fragmen dari cerita yang sama juga ditemukan di gerbang Kala-mrga. Selain itu, ditemukan pula fragmen ceritera Sudamala yang menggambarkan Bhima menyerang tokoh iblis di sebuah papan batu, sedangkan sejumlah relief Bhima lainnya yang belum dikenali asal ceriteranya ditemukan tersebar di halaman Kompleks Percandian Sukuh. Berdasarkan studi banding antara data artefaktual dan data tekstual penulis meyakini bahwa tokoh Bhima dipuja sebagai perantara antara Dewa Siwa dan orang-orang yang ingin mencapai pelepasan akhir (moksa). Peranan Bhima sebagai penyelamat manusia dapat dijumpai pada ceritera Bhimaswarga. Pada relief yang mengambarkan episode terakhir Bhimaswarga, tokoh Bhima digambarkan sedang diberi sebotol amrta oleh Siwa.
Necessary conditions for quasi-singular controls in the stochastic optimal control problem with delayed argument
Authors: Мансимов Камиль Байрамали{ }оглы , Масталиев Рашад Октай{ }оглы 
Published: May 2020

Рассмотрена задача оптимального управления, математические модели которых задаются нелинейными стохастическими дифференциальными уравнениями Ито с запаздывающим аргументом и диффузными компонентами, позволяющими учитывать действующие на систему случайные возмущения непрерывной природы.
В предположении выпуклости области допустимого управления получено линеаризованное необходимое условие оптимальности. Исследован квазиособый случай. Описаны общие необходимые условия оптимальности квазиособых управлений. Рассмотрены частные случаи.