bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraperitoneal versus retromuscular mesh placement for open incisional hernias: an analysis of the Americas Hernia Society Quality Collaborative
Authors: Fafaj A , Petro C C , Tastaldi L , Alkhatib H , AlMarzooqi R , Olson M A , Stewart T G , Prabhu A , Krpata D , Rosen M J 
Published: March 2020

Abstract

Background
Incisional hernia repair with mesh improves long-term outcomes, but the ideal mesh position remains unclear. This study compared intraperitoneal versus retromuscular or preperitoneal sublay (RPS) mesh positions for open incisional hernia repairs.

Methods
All patients who had elective open incisional hernia repairs were identified retrospectively in the Americas Hernia Society Quality Collaborative database. The primary outcome was the rate of 30-day surgical-site infection (SSI). Other outcomes of interest included 30-day surgical-site occurrences requiring procedural intervention (SSOPI), hernia-related quality-of-life survey (HerQLes) scores and long-term recurrence. A logistic model was used to generate propensity scores for mesh position using several clinically relevant co-variables. Regression models adjusting for propensity score and baseline characteristics were developed to assess the effect of mesh placement.

Results
A total of 4211 patients were included in the study population: 587 had intraperitoneal mesh and 3624 had RPS mesh. Analysis with propensity score adjustment provided no evidence for differences in SSOPI (odds ratio (OR) 0·79, 95 per cent c.i. 0·49 to 1·26) and SSI (OR 0·91, 0·50 to 1·67) rates or HerQLes scores at 30 days (OR 1·20, 0·79 to 1·82), or recurrence rates (hazard ratio 1·28, 0·90 to 1·82).

Conclusion
Mesh position had no effect on short- or long-term outcomes, including SSOPI and SSI rates, HerQLes scores and long-term recurrence rates.
Automated Java exceptions explanation using natural language generation techniques
Authors: Assiri Fatmah Yousef , Elazhary Hanan 
Published: March 2020

AbstractA common problem encountered by novice programmers and students taking introductory programming courses is how to understand exception messages and how to locate the corresponding errors. Such messages are typically too difficult for them to interpret without seeking help from colleagues or through online forums. Tackling this problem can help speed up their learning curves and hence increase their productivity. This paper proposes using natural language generation (NLG) techniques and the Rhetorical Structure Theory, which specifies how text spans are related and aggregated, to convert Java exception messages into readable and understandable natural language (NL) statements. An additional advantage is the possibility of adding more information and explanations that help students understand different exception types, their causes, and how they can be avoided. As a proof of concept, we developed Java Exceptions in the NL (JENL) tool to process Java exceptions using NLG techniques. Empirical evaluation has shown extreme satisfaction among Java programming subjects (including student novice programmers) with the capabilities of JENL as well as its usability.
Influence of Hydration on the Structure and Interactions of Ethaline Deep‐Eutectic Solvent: A Spectroscopic and Computational Study
Authors: Kalhor Payam , Zheng Yan‐Zhen , Ashraf Hamad , Cao Bobo , Yu Zhi‐Wu 
Published: March 2020

AbstractDeep‐eutectic solvents (DESs) are regarded as alternative green solvents to ionic liquids. In this work we report the structural properties and hydrogen bonding (H‐bonding) interactions of an aqueous DES system. The used DES, ethaline (ETH), is composed of choline chloride and ethylene glycol (EG) in 1 : 2 molar ratio. The investigations were carried out by FTIR spectroscopy combined with quantum chemical calculations. Excess spectroscopy and two‐dimensional correlation spectroscopy (2D‐COS) were used to explore the data in detail. The results showed that, upon mixing, ETH transforms to EG dimers and trimers and D2O clusters transform to various ETH‐D2O complexes. Theoretical calculations show that water molecules insert between the anion and cation of ETH, break the strong doubly ionic Cl−…H−OCh+ H‐bond, share charges of the ions and form H‐bond with them, thus modulate the interaction properties of ETH. This study deepens our molecular‐level understanding of the system and would shed light on its applications.
Impact of dominance effects on autotetraploid genomic prediction
Authors: Amadeu Rodrigo R. , Ferrão Luis Felipe V. , Oliveira Ivone de Bem , Benevenuto Juliana , Endelman Jeffrey B. , Munoz Patricio R. 
Published: March 2020

AbstractMany commercially important plants are autopolyploid. As a result of the multiple chromosome sets in their genomes, higher orders of allele interactions can occur, implying different degrees of dominance. In contrast with diploids, dominance effects can be heritable in polyploids, potentially having a higher impact on the prediction of genetic values. In this study, we investigated the role of additive and dominance effects in the prediction of genotypic values for complex traits in autotetraploid species in the context of genomic selection. As autotetraploid model species, we used data from breeding populations of blueberry (Vaccinium spp., n = 1804) and potato (Solanum tuberosum L., n = 560), assessing genetic parameters and prediction ability of five and two horticultural traits, respectively. Using a Bayesian framework, the genotypic effects were estimated based on (i) realized additive and digenic dominance relationship matrices, and (ii) all markers included as explanatory variables under ridge regression and Bayes B approaches. When included, dominance effects explained part of the estimated genetic variance and resulted in better goodness‐of‐fit values. However, their predictive ability was similar to the predictability obtained with additive models. Although we have considered only autotetraploid species in this study, many of the ideas and results should be of more general interest, with applications in species with higher ploidy level.
Leakage rate analysis with imperfect channel state information for cooperative nonorthogonal multiple access networks
Authors: Ozduran Volkan 
Published: March 2020

SummaryThis paper investigates the imperfect channel state information that is caused by the channel estimation error and feedback delay effects on the leakage rate analysis for the cooperative nonorthogonal multiple access networks. The investigation considers a dual hop one‐/two‐way nonorthogonal multiple access‐based information exchange process with the aid of half‐/full‐duplex untrustworthy wireless relaying network for the leakage rate analysis. The channel estimation error causes system coding gain losses while the feedback delay does not have any effect on the users' outage performance at untrustworthy relay terminal in low signal‐to‐noise ratio regimes. Conversely, the channel estimation error effects become negligible while the feedback delay causes system coding gain losses on the users' outage performance at untrustworthy relay terminal in high signal‐to‐noise ratio. Results also reveal that the untrustworthy relay terminal, which is under the effect of the channel estimation error and feedback delay, is being active between
and
‐
dB. Beyond
‐
dB, the untrustworthy relay terminal becomes out of order and saturates. The Monte Carlo–based simulation results are in agreement with the analytical and asymptotic derivations.
Climate change‐induced migration patterns and extinction risks of Theaceae species in China
Authors: Zhang Yinbo , Meng Qingxin , Wang Yuzhuo , Zhang Xiaolong , Wang Wei 
Published: March 2020

AbstractTheaceae, an economically important angiosperm family, is widely distributed in tropical and subtropical forests in Asia. In China, Theaceae has particularly high abundances and endemism, comprising ~75% of the total genera and ~46% of the total species worldwide. Therefore, predicting the response of Theaceae species to climate change is vital. In this study, we collected distribution data for 200 wild Theaceae species in China, and predicted their distribution patterns under current and future climactic conditions by species distribution modeling (SDM). We revealed that Theaceae species richness is highest in southeastern China and on Hainan Island, reaching its highest value (137 species) in Fujian Province. According to the IUCN Red List criteria for assessing species threat levels under two dispersal assumptions (no dispersal and full dispersal), we evaluated the conservation status of all Theaceae species by calculating loss of suitable habitat under future climate scenarios. We predicted that nine additional species will become threatened due to climate change in the future; one species will be classified as critically endangered (CR), two as endangered (EN), and six as vulnerable (VU). Given their extinction risks associated with climate change, we recommended that these species be added to the Red List. Our investigation of migration patterns revealed regional differences in the number of emigrant, immigrant, and persistent species, indicating the need for targeted conservation strategies. Regions containing numerous emigrants are concentrated in Northern Taiwan and coastal regions of Zhejiang and Fujian provinces, while regions containing numerous immigrants include central Sichuan Province, the southeastern Tibet Autonomous Region, southwest Yunnan Province, northwest Sichuan Province, and the junction of Guangxi and Hunan provinces. Lastly, regions containing persistent species are widely distributed in southern China. Importantly, regions with high species turnover are located on the northern border of the entire Theaceae species distribution ranges owing to upwards migration; these regions are considered most sensitive to climate change and conservation planning should therefore be prioritized here. This study will contribute valuable information for reducing the negative impacts of climate change on Theaceae species, which will ultimately improve biodiversity conservation efficiency.
Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients
Authors: Crnko Sandra , Printezi Markella I. , Jansen Tijn P.J. , Leiteris Laurynas , van der Meer Manon G. , Schutte Hilde , van Faassen Martijn , du Pré Bastiaan C. , de Jonge Nicolaas , Asselbergs Folkert W. , Gaillard Carlo A.J.M. , Kemperman Hans , Doevendans Pieter A. , Sluijter Joost P.G. , van Laake Linda W. 
Published: March 2020

AbstractAimSoluble suppression of tumorigenicity‐2 (sST2) is a strong prognostic biomarker in heart failure. The emerging understanding of circadian biology in cardiovascular disease may lead to novel applications in prognosis and diagnosis and may provide insight into mechanistic aspects of the disease–biomarker interaction. So far, it is unknown whether sST2 exhibits a diurnal rhythm. Repeated measurements of sST2 may aid in clinical decision making. The goal of this study was to investigate whether sST2 exhibits diurnal variation in patients with heart failure with reduced ejection fraction (HFrEF) and in control subjects, thereby enhancing its diagnostic and prognostic values.Methods and resultsThe study comprised 32 subjects: 16 HFrEF patients and 16 controls. Blood was collected at seven subsequent time points during a 24 h time period. sST2, N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), melatonin, and cortisol were measured from serum. Peak values of sST2 clustered at daytime (modal value: 5 p.m.) in 87.6% of all subjects (81.3% of patients, P = 0.021; 93.8% of controls, P = 0.001), and minimum concentrations at night‐time (modal value: 5 a.m.) in 84.4% (87.5% of patients, P = 0.004 81.3% of controls, P = 0.021). A cosinor analysis of mean normalized sST2 values revealed significant cosine shaped 24 h oscillations of patients (P = 0.026) and controls (P = 0.037). NT‐proBNP in contrast did not show a diurnal rhythm, while melatonin and cortisol patterns were intact in all subjects.ConclusionssST2 exhibits a diurnal rhythm with lower values in the morning than in the late afternoon. This new insight could lead to refinement of its diagnostic and prognostic values through specified and consistent sampling times with repeated measurements. For example, by measuring sST2 during the afternoon, when levels are at their highest, false negatives on prognosis prediction could be avoided.
Transthoracic echocardiography‐guided left bundle branch pacing without fluoroscopic guidance: A case report
Authors: Tan Kunyue , Deng Xiaoqi , Wang Shuzhen , Liu Chunxia , Zhao Ruohan , Xiong Feng 
Published: March 2020

AbstractThis case study demonstrates the feasibility of pacing the left bundle branch and atrial septum under transthoracic echocardiography (TTE) without fluoroscopic guidance. This technique could be useful to guide pacemaker implantation in some patients, especially pregnant women.
The Ramsey numbers of two sets of cycles
Authors: Wang Longqin , Chen Yaojun 
Published: March 2020

AbstractFor two given sets and of cycles, the Ramsey number is the smallest integer such that for any graph on vertices, either contains a cycle from or contains a cycle from . In this paper, we determine all Ramsey numbers , which confirms a conjecture due to Hansson, and extends the well‐known Ramsey numbers for two cycles.
A retrospect on antimicrobial potential of thiazole scaffold
Authors: Mishra Isha , Mishra Raghav , Mujwar Somdutt , Chandra Phool , Sachan Neetu 
Published: March 2020

AbstractDue to its appreciable diversity in biological actions, thiazole and its substituted components, a significant class of heterocyclic compounds has developed as an influential scaffold in the field of chemical sciences. The variability of thiazole core has been expressed through the effective instigation of its anticancer (Dasatinib, Tiazofurin), antiretroviral (Ritonavir, Brecanavir), antimicrobial (Sulfathiazole, Ravuconazole) and anti‐inflammatory (Fenclozic acid, Meloxicam) derivatives. This reasonable diversity in the physiological reaction pattern led many scientists to refine and develop new structural alternatives with much more efficient pharmacological action. This review is crucial for previous studies and projects to survey the antimicrobial activity of thiazole and thiazole related compounds to the mid of 2019.
Design, synthesis, and biological evaluation of sorafenib derivatives containing indole (ketone) semicarbazide analogs as antitumor agents
Authors: Li Wen , Qi Ya‐Yun , Wang Yuan‐Yuan , Gan Yi‐Yuan , Shao Li‐Hui , Zhang Li‐Qiong , Tang Zhen‐Hua , Zhu Mei , Tang Si‐Yu , Wang Zhen‐Chao , Ouyang Gui‐Ping 
Published: March 2020

AbstractA series of new sorafenib derivatives was designed and synthesized. The antiproliferative activity of the synthesized compounds against human lung cancer cell (A549), human pancreatic cancer cell (PC‐3), human leukemia cell (K562), and human hepatoma cell (SMMC‐7721) was evaluated by MTT assay. The results revealed that several compounds displayed more significant antitumor activities than commercial anticancer agent sorafenib against SMMC‐7721. In addition, compounds 7a, 7g, 7l, 7m, and 7p represented obvious growth inhibition with IC50 values of 1‐9 μM against four cancer cell lines, demonstrating more predominant activities against cancer cells as compared to sorafenib. Furthermore, some structure‐activity relationships have also been established. Compounds containing indole and benzene ring substituted by halogen showed better activity than sorafenib. Wound healing assay suggested that cells would be targeted on their migratory capacity by 7g, potentially affecting the migration activity of these tumors. The effects of A549 and PC‐3 cell apoptosis induced by compound 7g were significantly increased compared with sorafenib. Importantly, the result of western blot assay showed that 7g inhibited cell growth by suppressing the activity of EGFR, especially the expression of p‐EGFR (Tyr1068).
Potential utilities of mask‐wearing and instant hand hygiene for fighting SARS‐CoV‐2
Authors: Ma Qing‐Xia , Shan Hu , Zhang Hong‐Liang , Li Gui‐Mei , Yang Rui‐Mei , Chen Ji‐Ming 
Published: March 2020

AbstractThe surge of patients in the pandemic of COVID‐19 caused by the novel coronavirus SARS‐CoV‐2 may overwhelm the medical systems of many countries. Mask‐wearing and handwashing can slow the spread of the virus, but currently, masks are in shortage in many countries, and timely handwashing is often impossible. In this study, the efficacy of three types of masks and instant hand wiping was evaluated using the avian influenza virus to mock the coronavirus. Virus quantification was performed using real‐time reverse transcription‐polymerase chain reaction. Previous studies on mask‐wearing were reviewed. The results showed that instant hand wiping using a wet towel soaked in water containing 1.00% soap powder, 0.05% active chlorine, or 0.25% active chlorine from sodium hypochlorite removed 98.36%, 96.62%, and 99.98% of the virus from hands, respectively. N95 masks, medical masks, and homemade masks made of four‐layer kitchen paper and one‐layer cloth could block 99.98%, 97.14%, and 95.15% of the virus in aerosols. Medical mask‐wearing which was supported by many studies was opposed by other studies possibly due to erroneous judgment. With these data, we propose the approach of mask‐wearing plus instant hand hygiene (MIH) to slow the exponential spread of the virus. This MIH approach has been supported by the experiences of seven countries in fighting against COVID‐19. Collectively, a simple approach to slow the exponential spread of SARS‐CoV‐2 was proposed with the support of experiments, literature review, and control experiences.
Nontrauma fracture increases risk for respiratory disease among adults with cerebral palsy
Authors: Whitney Daniel G. 
Published: March 2020

AbstractIndividuals with cerebral palsy (CP) manifest skeletal fragility problems early in life and are vulnerable to nontrauma fracture (NTFx), which may exacerbate the risk of respiratory disease (RD)– the main cause of premature mortality for this population. The purpose of this study was to determine if adults with CP had a greater 12‐month risk of RD post‐NTFx compared to adults without CP. Data from 2011 to 2017 were leveraged from Optum Clinformatics Data Mart; a claims database from a single private payer in the United States diagnostic codes were used to identify adults (≥18 years) with and without CP, NTFx, incident RD, and pre‐NTFx cardiometabolic diseases. Cox proportional hazards regression models were used to compare 12‐month RD incidence following NTFx with adjustment for sociodemographics and cardiometabolic diseases. Mean age (SD) at baseline was 57.5 (18.4) for adults with CP (n = 646) and 61.8 (19.7) for adults without CP (n = 321,482). During the follow‐up, 172 adults with CP (26.6%) and 73 937 adults without CP (23.0%) developed RD. Adults with CP had higher 12‐month post‐NTFx RD incidence compared to adults without CP (hazard ratio [HR] = 1.20; 95% confidence interval [CI] = 1.03‐1.37). When stratified by the RD subtype, adults with CP had a higher incidence of pneumonia (HR = 2.15; 95% CI = 1.56‐2.95), interstitial/pleura disease (HR = 2.13; 95% CI = 1.53‐2.96), and other RD (eg, respiratory failure; HR = 2.33; 95% CI = 1.82‐2.98), but not acute respiratory infection (HR = 0.93; 95% CI = 0.75‐1.15) or chronic obstructive pulmonary disease (HR = 1.15; 95% CI = 0.86‐1.53). Among privately insured adults with CP, NTFx is associated with greater risk of RD among adults with vs without CP.
Neoadjuvant radiation improves margin‐negative resection rates in extremity sarcoma but not survival
Authors: Shelby Rita D. , Suarez‐Kelly Lorena P. , Yu Peter Y. , Hughes Tasha M. , Ethun Cecilia G. , Tran Thuy B. , Poultsides George , King David M. , Bedi Meena , Mogal Harveshp , Clarke Callisia , Tseng Jennifer , Roggin Kevin K. , Chouliaras Konstantinos , Votanopoulos Konstantinos , Krasnick Bradley A. , Fields Ryan C. , Pollock Raphael E. , Howard J. Harrison , Cardona Kenneth , Grignol Valerie 
Published: March 2020

AbstractBackground and ObjectivesRadiation improves limb salvage in extremity sarcomas. Timing of radiation therapy remains under investigation. We sought to evaluate the effects of neoadjuvant radiation (NAR) on surgery and survival of patients with extremity sarcomas.Materials and MethodsA multi‐institutional database was used to identify patients with extremity sarcomas undergoing surgical resection from 2000‐2016. Patients were categorized by treatment strategy: surgery alone, adjuvant radiation (AR), or NAR. Survival, recurrence, limb salvage, and surgical margin status was analyzed.ResultsA total of 1483 patients were identified. Most patients receiving radiotherapy had high‐grade tumors (82% NAR vs 81% AR vs 60% surgery;P < .001). The radiotherapy groups had more limb‐sparing operations (98% AR vs 94% NAR vs 87% surgery;P < .001). NAR resulted in negative margin resections (90% NAR vs 79% surgery vs 75% AR;P < .0001). There were fewer local recurrences in the radiation groups (14% NAR vs 17% AR vs 27% surgery;P = .001). There was no difference in overall or recurrence‐free survival between the three groups (OS,P = .132; RFS,P = .227).ConclusionIn this large study, radiotherapy improved limb salvage rates and decreased local recurrences. Receipt of NAR achieves more margin‐negative resections however this did not improve local recurrence or survival rates over.
Long‐term effects of ivacaftor on nonpulmonary outcomes in individuals with cystic fibrosis, heterozygous for a S1251N mutation
Authors: Burghard M (Marcella) , Berkers G (Gitte) , Ghijsen S (Sophie) , Hollander‐Kraaijeveld FM (Francis) , de Winter‐de Groot KM (Karin) , van der Ent CK (Kors) , Heijerman HGM (Harry) , Takken T (Tim) , Hulzebos HJ (Erik) 
Published: March 2020

AbstractObjectivesTo describe the long‐term effects of ivacaftor (Kalydeco®) in individuals with cystic fibrosis (CF) on body mass index (BMI), body composition (BC), pulmonary function (PF), resting energy expenditure (REE), and exercise capacity (EC) after ≥12 months of treatment.Working HypothesisBMI, lean and fat mass, PF, and EC will increase and REE will decrease after treatment.Study DesignObservational study.MethodologySeven individuals with CF (mean age 15.4 ± 5.8 years) heterozygous for S1251N mutation, starting with ivacaftor, were included. Paired t tests were performed to assess the effects of ivacaftor. Height and weight were used to calculate BMI and BMI Z‐scores. Dual‐energy X‐ray absorptiometry was used to assess BC. Spirometry and body plethysmography were used to assess PF. Indirect calorimetry was used to measure REE and cardiopulmonary exercise testing (CPET) was used to measure oxygen uptake (VO2peak), peak work rate (Wpeak), and other CPET variables.ResultsAfter a median of 15 (interquartile range: 13‐16) months of treatment, BMI increased significantly (P = .03), but not BMI Z‐score (P = .23) or BC. Significant improvements were found for several PF variables, especially measures of hyperinflation (P = .02). Absolute VO2peak (P = .01), VO2peak related to body weight (P = .00), and oxygen cost of work (P = .01) decreased. Absolute Wpeak (P = .59) and Wpeak related to body weight (P = .31) remained stable.ConclusionsThe results showed that long‐term treatment of ivacaftor is associated with improvement of BMI and PF, but not of BC and REE. Oxygen uptake reduced after treatment, which may be due to a decrease in work of breathing.