bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiplexed therapeutic drug monitoring of antipsychotics in dried plasma spots by LC‐MS/MS
Authors: Ruggiero Carla , Ramirez Stefania , Ramazzotti Eric , Mancini Rita , Muratori Roberto , Raggi Maria Augusta , Conti Matteo 
Published: February 2020

AbstractIn this work, a convenient method for the therapeutic monitoring of seven common antipsychotic drugs in “dried plasma spot” samples has been developed. It is based on the liquid chromatography tandem mass spectrometry technique, operating in multiple reaction monitoring mode, and a straightforward procedure for the simultaneous extraction of all antipsychotics in a single step, with high extraction yield. The method was fully validated with proper accuracy, precision, selectivity and sensitivity, for all the drugs. Limits of quantification were 0.12, 1.09, 1.46, 1.47, 5.70, 1.32, 1.33 µg/L for haloperidol, aripiprazole, olanzapine, quetiapine, clozapine, risperidone, and paliperidone, respectively. Accuracy, intra‐ and interday precision values were <10% for all drugs at all concentration levels examined. The method was tested in the analysis of 30 plasma samples from real patients for each drug. The proposed analytical approach, by combining practical and logistical advantages of microsampling with liquid chromatography tandem mass spectrometry analytical performance, could offer an ideal strategy for accurate and timely therapeutic drug monitoring of antipsychotic drugs in most clinical settings, even in remote centers and/or in out‐patient settings, bringing so many potential improvements in psychiatric patient care.
Understanding the evolution of China's tourism industry performance: An internal–external framework
Authors: Wei Min , Peng Qian , Chen Ming‐Hsiang , Su Ching‐Hui (Joan) 
Published: February 2020

AbstractThis study traces the evolution of China's tourism industry performance. It uses an internal–external framework to evaluate external factors from the macroperspective and microperspective and examines internal factors through a supply and demand standard. We apply a variable coefficient system to optimize the index system and produce a measurement model consisting of 14 indicators, weighing the significance of each indicator via information entropy. Findings from the empirical analysis indicate that substitution and complementary indicators influence the evolution of the tourism industry, suggesting that the synergy effect of various factors should be investigated as the tourism industry continues to mature.
Usefulness of the Contrast‐Enhanced Ultrasound Liver Imaging Reporting and Data System in Diagnosing Focal Liver Lesions by Inexperienced Radiologists
Authors: Wang Jia‐Yu , Feng Shao‐Yang , Xu Jian‐Wei , Li Jun , Chu Liang , Cui Xin‐Wu , Dietrich Christoph F. 
Published: February 2020

ObjectivesTo evaluate the usefulness of the contrast‐enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI‐RADS) in diagnosing focal liver lesions (FLLs) by inexperienced radiologists.MethodsImages and clinical data from 258 patients at risk for hepatocellular carcinoma who underwent CEUS were collected retrospectively. Two trained inexperienced radiologists and 2 experienced radiologists reviewed all CEUS clips. Each inexperienced radiologist assigned a CEUS LI‐RADS category for each observation and labeled it benign or malignant independently. Each experienced radiologist labeled each lesion malignant or benign independently using a conventional diagnostic method. Interobserver agreement of CEUS LI‐RADS was analyzed by the κ test. The overall diagnostic accuracy of the LI‐RADS category and conventional diagnosis was described by the sensitivity, specificity, positive predictive value, and negative predictive value. All test results were considered significant at P < .05.ResultsA κ value of 0.774 indicated that the CEUS LI‐RADS algorithm resulted in substantial consistency between the inexperienced radiologists. For the diagnosis of hepatocellular carcinoma, the sensitivity, specificity, positive predictive value, and negative predictive value were improved significantly in inexperienced radiologists using the CEUS LI‐RADS compared to conventional methods. The overall diagnostic accuracy of the experienced radiologists was almost equal to that of CEUS LI‐RADS categories assigned by the inexperienced radiologists.ConclusionsThe CEUS LI‐RADS algorithm can not only obtain substantial consistency among inexperienced radiologists but also have excellent diagnostic efficacy in the differentiation of benign from malignant FLLs compared to conventional methods. As a comprehensive algorithm, the CEUS LI‐RADS can act as a guide for trainees in learning how to diagnose FLLs.
Readability of Patient‐Reported Outcome Measures for Head and Neck Oncology
Authors: Lee Saangyoung E. , Farzal Zainab , Ebert Charles S. , Zanation Adam M. 
Published: February 2020

Objectives/HypothesisPatient‐reported outcome measures (PROMs) are communication tools to help patients convey their disease experience to medical providers and guide management decisions. However, the utility of healthcare outcome measures is dependent on patient literacy and readability of PROMs. If written for a more advanced literacy level, they can misestimate symptoms and add significant barriers to care, especially in the underserved. However, readability of head and neck (H&N) oncology PROMs has not been assessed. The aim of this study was to evaluate the readability of H&N oncology PROMs to assess whether they meet recommended readability levels.Study DesignBibliometric review.MethodsThree readability measures: Gunning Fog, Simple Measure of Gobbledygook, and FORCAST were used to evaluate the readability level of commonly used H&N PROMs. PROMs with sixth grade readability level or lower were considered to meet the recommendations of health literacy experts.ResultsEight H&N oncology PROMs were reviewed. None of H&N PROMs met health literacy experts' and National Institutes of Health recommended reading levels. Gunning Fog consistently estimated easiest readability and FORCAST the most difficult.ConclusionsPROMs are important clinical tools that drive patient‐centric care in H&N oncology. All H&N PROMs are written above recommended reading levels and do not meet suggested standards. Future PROMs should be written with easier readability to accurately convey patients' H&N oncology disease experiences.Level of Evidence4 Laryngoscope, 2020
Solvent‐Free Generation of Foamed Microcapillary Films with a Dual Network of Interconnected Pores and Internal Channels
Authors: Zhao Jianxiang , Xu Zhongbin , Zheng Suxia , Liu Cong , Liu Junfeng , Pei Hao 
Published: February 2020

AbstractA dual‐pore network is favored in applications such as tissue engineering scaffolds. In this paper, foamed microcapillary films (FMCFs) are prepared based on a poly(lactic acid)/poly(butylene succinate) blend using melt extrusion and batch foaming with supercritical carbon dioxide. Such films are characterized by multiple hollow microcapillaries (diameter of 100–360 µm) connected with cells (size of 3–194 µm, open‐cell content of over 80%) within the scaffold. By plugging the ends of the MCF before foaming, the formation of a solid skin layer is successfully avoided. Furthermore, the diameter of the microcapillaries of an FMCF can be adjusted using the designed foaming strategy. The effects of the foaming condition on the FMCF foaming behavior are also investigated. When other conditions are fixed, the foaming behavior changes dramatically when the foaming temperature changes within the range of 120–123 °C.
Olfactory priming on consumer categorization, recall, and choice
Authors: De Luca Ramona , Botelho Delane 
Published: February 2020

AbstractConsumer choices are mostly regulated by pleasurable experiences that arise outside of the individuals' awareness in response to sensory attributes. This research examines the unconscious mechanism underlying consumers' behavior in response to odors applying the priming approach. Five experiments show that individuals' responses to odors involve two mechanisms, one affective (affective priming) and one associative (semantic priming) that impact consumers' categorization, recall, and choice. We found that when individuals perceive an odor as pleasant, their memory for odor‐congruent brand logos (Experiment 1), and categorization of odor‐congruent visual objects (Experiment 2) is improved. Unpleasant odors, instead, improve the categorization of odor‐congruent visual objects only when they are made salient (Experiments 3 and 4). A pleasant odor diffused in the environment also drives consumers toward odor‐congruent choices (Experiment 5), providing evidence that the incidental exposure to odors may induce affective and semantic associations with unrelated objects and behaviors. We also demonstrate that olfactory cues might be more effective than other modality (visual) stimuli to drive consumer responses. An implication for marketing is that odors employed in retail settings not only may induce an experience of pleasure but also promote specific consumer responses, such as categorization, recall, and choice.
Magnetorheological Elastomer Composites: The Influence of Iron Particle Distribution on the Surface Morphology
Authors: Samal Sneha , Kolinova Marcela , Blanco Ignazio , Poggetto Giovanni Dal , Catauro Michelina 
Published: February 2020

AbstractIron particles ranging from 50 to 150 µm are incorporated in an elastomer matrix to obtain magnetorheological elastomer (MRE) composites, aiming to investigate their effects on the surface morphology. The isotropic and anisotropic distribution of fillers are estimated in MRE composites. A simulation analysis is carried out to predict the particle distribution in MRE composites, and a correlation between the experimental observation and simulation analysis is established. The volume fraction of 30 vol% is chosen as the optimal quantity for the filler amount in elastomer composite.
New Proposed Method for the Analysis of Biomaterials in Foot Insoles
Authors: Braun Barbu Cristian , Drugă Corneliu Nicolae , Şerban Ionel , Necula Necula 
Published: February 2020

AbstractIn this paper, a stage of a research activity in the orthopedic field for testing modern materials composing foot insoles at different tasks, such as simulating walking, running, orthostatic position, or sitting, is described. This stage concerns the testing of five samples of materials taken from five patterns of inlets, subject to a degradation process, over different time periods. The degradation process consists of subjecting the immersed samples to a 15–20% saline solution at static loads of about 400 N. The salinity percentage is established so that the solution obtained is similar to that of sweat, which occurs especially in the warm season while wearing the shoes. The exposure to degradation times is established at 3 and 7 days, respectively. The main aspects are the degree of compaction and the degree of deformation of the samples, as a result of maintaining different times in degradation conditions.
AFM Studies of Chitosan, Gold‐Chitosan, and Silver‐Chitosan Films Morphology
Authors: Rubina Margarita , Elmanovich Igor , Vasil'kov Alexander 
Published: February 2020

AbstractAtomic force microscopy is used in this work as a primary tool for investigating chitosan‐based films morphology. Chitosan films casted from chitosan solutions in acetic acid of various concentrations, as well as gold‐ and silver‐containing chitosan films, are studied. Chitosan films are revealed to be composed of globular‐like structures with 20–80 nm lateral sizes. At a higher chitosan concentration, a tendency is observed for these globular‐like structures to be organized in fibril‐like “strands.” The presence of metal does not seem to affect the general structure of chitosan‐based films.
Composite Material Cracks Detection Using a Self‐Interference Long Period Grating Fiber Sensor
Authors: Savastru Dan , Baschir Laurentiu , Miclos Sorin , Savastru Roxana , Lancranjan Ion 
Published: February 2020

AbstractThe purpose of this paper is to present a new method of detecting cracks that appear in the polymer matrix of a smart composite material using a self‐interference long period grating (SILPG) fiber sensor setup. Strain and torsion deformations of the polymer matrix induced by the cracks effects on SILPG are exploited for crack detection. Different other features of the crack mechanism that induce a change in the SILPG status and response are identified. The response of SILPG fiber sensor under host composite material host crack action is investigated and simulated for defining the functional limits of the composite material. SILPG fiber sensor is considered as embedded in polymer matrix of composite material. SILPG is operated as the signal source of the smart composite material feedback loop.
Polymer Optical Fibers for Sensing
Authors: Cennamo Nunzio , Zeni Luigi 
Published: February 2020

AbstractSensing techniques based on optical fibers are used in numerous key fields. For example, optical fiber sensors are exploited in medical diagnostics, environmental monitoring, physical parameters detection, industrial applications, food safety, and security. In fact, optical fiber sensors are used for their numerous capabilities, as for example when in the detection fast, portable, low‐cost, small size, and/or rugged sensor systems are needed. In general, the optical fiber for sensing applications can be a glass one, a specialty one, or a polymer one. Polymer optical fibers (POFs) are especially advantageous due to their excellent flexibility, easy manipulation, large diameter, resilience, and the fact that plastic is able to withstand smaller bend radii than glass. These POF sensors, intrinsic and extrinsic, combined with different kinds of receptors can be directly connected to an online platform by interface software, allowing storing, analyzing, and displaying the sensor's data, to realize low‐cost biochemical sensors for several applications. In this work, two plasmonic POF sensors, one intrinsic and another one extrinsic, that can be used in biochemical applications are described.
Spectroscopic, Thermal Analysis and Bioactivity Study of New Ferrous Citrate Based Materials Prepared by Sol–Gel Method
Authors: Ciprioti Stefano Vecchio , Naviglio Daniele , Gallo Monica , Barrino Federico , Catauro Michelina 
Published: February 2020

AbstractThe aim of this work is the development of a system able to release ferrous ions in a controlled manner. An interesting alternative to a systemic therapy can be the use of controlled drug release for medical applications. Starting from iron powder and citric acid, ferrous citrate (Fe(II)C) is synthesized by a redox reaction between these two. The confirmation that only Fe(II)C is obtained by redox reaction is shown from Fourier transform infrared spectroscopy (FTIR), 1,10‐phenanthroline and sodium thiocyanate colorimetric experiments. Fe(II)C is embedded within a SiO2 matrix in different weight percentage by means of a sol–gel route. The presence of Fe(II)C in the silica matrix is confirmed by FTIR spectroscopy and thermogravimetry assays. Furthermore, these two techniques are used to investigate the thermal behavior of the above‐mentioned sol–gel materials. The bioactivity test carried out by soaking the synthesized complex delivery systems in a simulated body fluid shows that the biological properties of the silica matrix are not modified by the presence of Fe(II)C.
Validation of a Numerical Fluid Flow Analysis for a Helicopter Tail Rotor Blade Using a Subsonic Wind Tunnel
Authors: Voicu Andrei Daniel , Hadăr Anton , Vlăsceanu Daniel 
Published: February 2020

AbstractIn the study of the aerodynamic load applied by the air on the rotating helicopter blade, it is important to know that the values obtained from the numerical analysis are as close to reality as possible, within an acceptable limit. Therefore, in order to realize and obtain a pertinent result from a structural analysis, based on pressure loads obtained from the airflow surrounding the blade, it is important that the fluid flow results are certified by comparison with experimental result. In order to achieve this purpose, the tail rotor blade of the Romanian Air Force IAR330 helicopter has been modeled using Ansys Workbench and by using Fluid Flow, the values of the pressures on the main blade surfaces have been determined. The experimental values of the aerodynamic pressure have been determined using a 1:1 scale model of the blade, placed in the subsonic aerodynamic wind tunnel at INCAS Bucharest.
Thermo‐Mechanical Investigation on an Automotive Engine Encapsulation System Made of Fiberglass Reinforced Polyamide PA6 GF30 Material
Authors: Caputo Francesco , Lamanna Giuseppe , De Luca Alessandro , Armentani Enrico 
Published: February 2020

AbstractThis paper deals with technological solutions of innovative engine encapsulation systems for automotive. The aim of this device is to insulate acoustically and thermally the engine from the environment, in order to keep its temperature higher for more hours after it has been switched off. If the engine is subsequently started within this interval, the higher temperature involving the lubricating oil will allow reducing its viscosity, resulting in a lower level of energy dissipation due to friction losses, a lower fuel consumption and, consequently, a lower CO2 emission level. In this paper, a finite element model is carried out in order to investigate on the thermo‐mechanical behavior of the proposed engine encapsulation system.
Design of a Bamboo Treadmill Bicycle Main Frame
Authors: Perfetto Donato , Lamanna Giuseppe , Sepe Raffaele , De Luca Alessandro 
Published: February 2020

AbstractIn the present work, a preliminary design of an eco‐sustainable bamboo electric treadmill bike is carried out. It is a new means of transport with zero environmental impact that also allows to overcome the main disadvantage of the indoor training. Bamboo, as an eco‐friendly material, has great potential as construction material for bike frames because it represents an alternative for more traditional materials such as steel, aluminum, and composite. A finite element model of the designed prototype is developed and then validated using Abaqus commercial code following the UNI EN 14764 static standard. Numerical analyses show good structural behavior of the designed frame in compliance with the regulations.
BMI‐Based Coupling Agent to Improve Adhesion in Self‐Healing Composites
Authors: Iacono Stefania Dello , Amendola Eugenio , Martone Alfonso 
Published: February 2020

AbstractRecently, the availability of thermo‐reversible epoxies is interesting for research and industry due to its implication in the implementation of the next generation of advanced materials. However, fiber‐reinforced composites made with self‐healing epoxies have lower performances than commercial products. Therefore, the availability of a suitable treatment to improve the adhesion between fiber and matrix will compensate the lack of performances experienced in thermo‐reversible composites. Here, a route for decorating dry commercial preform with bismaleimide (BMI) is presented in order to promote the adhesion between matrix and reinforcement. The grafting of BMI on the glass support is measured by means of contact angle. The interfacial strength between fiber and resin is measured by micro‐droplet pull‐out test. The BMI‐based coupling agent leads to a 92% increase in interfacial strength for a self‐healing system.
LncRNA NEAT1/miR‐185‐5p/IGF2 axis regulates the invasion and migration of colon cancer
Authors: Zhuang Shu‐tong , Cai Yan‐juan , Liu Hong‐peng , Qin Ying , Wen Jian‐feng 
Published: February 2020

AbstractBackgroundLong noncoding RNAs (lncRNA) are important in the growth and metastasis of colon cancer. The objective of this study was to describe the potential role of lncRNA NEAT1 in the progression of colon cancer.MethodsQuantitative real‐time polymerase chain reaction was used for detecting NEAT1, miR‐185‐5p, and IGF2 in colon cancer cells and tissues. The potential diagnostic value of NEAT1 in colon cancer was analyzed with the receiver operating characteristic curve. Kaplan–Meier method was applied for evaluating the association between NEAT1 expression and the overall survival of osteosarcoma patients, whereas Transwell assay was introduced to examine the potential invasion and migration of colon cancer cells. In addition, the binding of NEAT1/IGF2 to miR‐185‐5p was confirmed by RNA pull‐down and RNA‐binding protein immunoprecipitation assays and dual‐luciferase reporter gene assay. Finally, rescue experiments were conducted to confirm the role of NEAT1/miR‐185‐5p/IGF2 axis in colon cancer.ResultsColon cancer patients with low NEAT1 expression presented with longer overall survival than those with high expression. The migration and invasion of colon cancer cells were considerably promoted by overexpressed NEAT1. Both NEAT1 and IGF2 bound to miR‐185‐5p.ConclusionNEAT1 upregulate IGF2 expression through absorbing miR‐185‐5p to enhances the migration and invasion of colon cancer cells.
MicroRNA‐150 serves as a diagnostic biomarker and is involved in the inflammatory pathogenesis of Parkinson's disease
Authors: Li Haiting , Yu Ling , Li Min , Chen Xiaohui , Tian Qun , Jiang Yanyan , Li Nan 
Published: February 2020

AbstractBackgroundDysregulation of microRNAs (miRNAs) has been reported to be involved in the neuroinflammatory pathogenesis of PD. This study aimed to investigate the serum expression of microRNA‐150 (miR‐150) in Parkinson's disease (PD) patients and further uncover the regulatory effect of miR‐150 on neuroinflammation.MethodsQuantitative Real‐Time PCR was used to measure the expression of miR‐150. A receiver operating characteristic curve was applied to evaluate the diagnostic value of miR‐150. The effect of miR‐150 on neuroinflammation was analyzed by examining its correlation with proinflammatory cytokines and gain‐of‐function experiments in microglia treated with LPS.ResultsSerum miR‐150 expression was downregulated in PD patients compared with the healthy controls, and served as a candidate diagnostic biomarker for the screening of PD cases. Negative correlation was found between miR‐150 levels and the levels of procytokines in PD patients. By the treatment of LPS, microglia BV2 cells had a reduced expression of miR‐150, and the enhanced neuroinflammatory responses were inhibited by the overexpression of miR‐150. AKT3 was verified as a target of miR‐150 in BV2 cells.ConclusionAll the data of this study revealed that the decreased serum miR‐150 serves as a potential diagnostic biomarker. The methods to increase miR‐150 expression may have a beneficial effect in PD via suppressing the neuroinflammation by targeting AKT3.