bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ligustrazine inhibits the proliferation and migration of ovarian cancer cells via regulating miR-211
Authors: Zhang Hairong , Ding Shichao , Xia Lei 
Published: November 2020

Abstract
Ovarian cancer (OC) is a commonly diagnosed female cancer. Ligustrazine (LSZ), a natural compound, has been reported to exert anti-cancer activity, although the mechanisms underlying the anti-cancer effects are not clear. The present study investigated the impact of LSZ on cell proliferation and migration by regulating microRNA-211 (miR-211) expression using the human ovarian cancer SK-OV-3 and OVCAR-3 cell lines. OC cells were treated with 0, 0.5, 1, and 2 mM LSZ, and quantitative real-time PCR was utilized to measure miR-211 levels in SK-OV-3 and OVCAR-3 cells with different treatment. Moreover, to further confirm the roles of miR-211 in LSZ induced anti-tumor effects, miR-211 expression was inhibited by transfection of miR-211 inhibitors in SK-OV-3 cells. Cell proliferation of transfected cells was evaluated using the CCK-8 and colony formation assay. The scratch assay was employed to assess cell migration and transwell assay was performed for evaluating the cell invasion. Protein levels of epithelial–mesenchymal transition (EMT) markers were determined by Western blotting. We found that LSZ inhibited the viability, proliferation, migration and invasion ability of SK-OV-3 and OVCAR-3 cells in a dose-dependent manner; moreover, LSZ could significantly increase the expression of miR-211 in both SK-OV-3 and OVCAR-3, and knockdown of miR-211 in SK-OV-3 cells partially abrogated the anti-tumor behavior of LSZ by promoting the viability, proliferation, migration, invasion and EMT of SK-OV-3 cells. Thus, we found that LSZ can inhibit the proliferation and migration of OC cells via regulating miR-211. Our study suggests that LSZ might be a potential and effective treatment for OC.
Regulation of circGOLPH3 and its binding protein CBX7 on the proliferation and apoptosis of prostate cancer cells
Authors: Gong Lifeng , Tang Yu , Jiang Li , Tang Wei , Luo Shengjun 
Published: November 2020

Abstract
To clarify the mechanism of circGOLPH3 regulation on prostate cancer cells, we performed an overexpression and interference circGOLPH3 assay in prostate cancer cells PC-3 and then evaluated cellular viability, proliferation, cell cycle, and apoptosis of prostate cancer cells by MTT, CCK8, Edu stain, TUNEL stain, and flow cytometry. Binding proteins of CircGOLPH3 were identified by RNA pull-down, mass spectrometry, and RNA-binding protein immunoprecipitation (RIP) assays. The expressions of CircGOLPH3 and CBX7 were measured by qRT-PCR. The results showed that after overexpression of circGOLPH3, the proliferative capacity and the viability of PC-3cells were significantly improved, whereas apoptosis was inhibited. CircGOLPH3 could bind to the CBX7 protein that was highly expressed in the PC-3 cell. Additionally, a functional test on CBX7 showed that the CBX7 overexpression notably improved the proliferative capacity and the viability of PC-3 cells and decreased cellular apoptosis, which was consistent with the effects of circGOLPH3. The validated the present study that circGOLPH3 and its binding protein CBX7 can promote prostate cancer cell proliferation and inhibit apoptosis.
Iron stores at birth in a full-term normal birth weight birth cohort with a low level of inflammation
Authors: Zhang Joy Y. , Wang Jing , Lu Qinsheng , Tan Meizhen , Wei Ru , Lash Gendie E. 
Published: November 2020

AbstractIron stores at birth are essential to meet iron needs during the first 4–6 months of life. The present study aimed to investigate iron stores in normal birth weight, healthy, term neonates. Umbilical cord blood samples were collected from apparently normal singleton vaginal deliveries (n=854). Subjects were screened and excluded if C-reactive protein (CRP) &gt; 5 mg/l or α1-acid glycoprotein (AGP) &gt; 1 g/l, preterm (&lt;37 complete weeks), term &lt; 2500g or term &gt; 4000g. In total, 762 samples were included in the study. Serum ferritin, soluble transferrin receptor (sTfR), hepcidin, and erythropoietin (EPO) were measured in umbilical cord blood samples; total body iron (TBI) (mg/kg) was calculated using sTfR and ferritin concentrations. A total of 19.8% newborns were iron deficient (ferritin 35 μg/l) and an additional 46.6% had insufficient iron stores (ferritin &lt; 76 μg/l). There was a positive association between serum ferritin and sTfR, hepcidin, and EPO. Gestational age was positively associated with ferritin, sTfR, EPO, and hepcidin. In conclusion, we demonstrate a high prevalence of insufficient iron stores in a Chinese birth cohort. The value of cord sTfR and TBI in the assessment of iron status in the newborn is questionable, and reference ranges need to be established.
Evaluation of small unmanned aerial system highway volume and speed‐sensing applications
Authors: Ryan Alyssa , Ai Chengbo , Knodler Michael , Fitzpatrick Cole 
Published: November 2020

AbstractSmall unmanned aerial systems (sUAS) have been utilised in the transportation industry in recent years to decrease the cost of projects and tasks while increasing safety. This is due to their ability to capture aerial images with reduced effort and time. Recently, these devices have begun to be used for traffic monitoring, given their ability to capture video above a roadway. Combined with object‐tracking techniques, vehicle data such as speeds, volumes, and trajectories could be extracted, providing an opportunity to revolutionize traffic data collection techniques. There exists a need to improve upon origin–destination volume and speed data collection procedures through the development of a low‐cost methodology to capture detailed data that would allow for more accurate analysis. This study evaluates a methodology and measures the accuracy of volume and speed data collected through sUAS aerial imagery using object tracking techniques. Using the developed methodology, vehicle volumes were tracked at 93% accuracy, and vehicle speeds were recorded with a 6.6% relative error. While future improvements could be made on this methodology as technology advances, this study reveals a low‐cost solution to collect vehicle data which could improve the efficiency of transportation studies, and in turn, improve safety.
Multiparametrische quantitative Magnetresonanztomografie bei Lebererkrankungen
Authors: Haimerl Michael , Stroszczynski Christian , Senk Karin 
Published: November 2020

ZusammenfassungDie MRT wird routinemäßig bei Patienten mit einer Erkrankung der Leber zum Ausschluss oder zur Verlaufskontrolle einer strukturellen Parenchymveränderung eingesetzt. Durch spezielle MRT-Sequenzen und -Techniken lassen sich Eigenschaften der Leber bezüglich Funktion, Fibrosestadium, Fett- und Eisengehalt quantifizieren. Die MRT hilft sowohl bei der ersten Diagnostik eines Krankheitsbildes als auch bei der Überprüfung des Therapieansprechens.
Risk of a post-colonoscopy colorectal cancer diagnosis in patients with inflammatory bowel disease: a population-based cohort study
Authors: Schønfeldt Troelsen Frederikke , Sørensen Henrik Toft , Pedersen Lars , Erichsen Rune 
Published: November 2020

AbstractBackground Post-colonoscopy colorectal cancers (PCCRCs) may account for up to 50 % of all colorectal cancers (CRCs) diagnosed in patients with inflammatory bowel disease (IBD). This may reflect a high colonoscopy frequency; however, evidence remains limited.Methods We conducted a cohort study of IBD and non-IBD patients undergoing colonoscopy. We calculated cumulative incidence proportions (CIPs) of PCCRC at 7–36 months after first-time and subsequent colonoscopies. We also computed crude and adjusted hazard ratios (HRs) of PCCRC, comparing IBD with non-IBD patients undergoing first-time and subsequent colonoscopies. Separate analyses were conducted for consecutive colonoscopies. We calculated 3-year rates of PCCRC to estimate the proportion of IBD and non-IBD CRC patients experiencing PCCRC.Results We observed 138 and 1909 PCCRCs among 34 688 IBD and 358 217 non-IBD patients who underwent colonoscopy. The CIP of PCCRC after first-time colonoscopy was 0.21 % (95 % confidence interval [CI] 0.17 %–0.27 %) for IBD patients and 0.37 % (95 %CI 0.35 %–0.39 %) for non-IBD patients. The adjusted HR of PCCRC after a first-time colonoscopy was 0.96 (95 %CI 0.75–1.22) and the adjusted HRs after subsequent colonoscopies had point estimates around 1.0. The 3-year PCCRC rate was 24.3 % (95 %CI 20.4 %–28.7 %) for IBD and 7.5 % (95 %CI 7.2 %–7.8 %) for non-IBD patients.Conclusions Although PCCRCs accounted for a substantial proportion of all IBD-related CRCs, IBD patients had a low CIP of PCCRC. The elevated 3-year PCCRC rates may, among other factors, stem from the increased colonoscopy frequency in IBD patients.
Far Lateral Approach for Disconnection of Craniocervical Junction Dural Arteriovenous Fistula Presented with Myelopathy and Hydrocephalus
Authors: Lam Siu Kei Samuel , Chu Sai Lok , Yuen Shing Chau , Yam Kwong Yui 
Published: November 2020

AbstractWe report a case of craniocervical junction dural arteriovenous fistula (dAVF) presented with myelopathy and normal pressure hydrocephalus, and was treated with hybrid approach of embolization and surgical disconnection. A 68-year-old gentleman presented with 1 year history of unsteady gait and sphincter disturbance. Magnetic resonance imaging (MRI) showed abnormally enlarged and tortuous vessels over right cerebellomedullary cistern. Digital subtraction angiogram (DSA) showed Cognard's type-V dAVF at craniocervical junction. Catheter embolization was performed via external carotid artery and finally surgical disconnection was done with far lateral approach (Fig. 1). Postoperative DSA showed no more arteriovenous shunting (Fig. 2). Clinically the patient improved after a course of rehabilitation. Dural AVF at craniocervical junction is rare and its clinical presentation can be highly variable from subarachnoid hemorrhage to brainstem dysfunction. Identification of the exact fistula site is essential in surgical planning. Surgery is effective and safe to achieve complete obliteration and good clinical outcome.1
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The link to the video can be found at: https://youtu.be/xI48stSlWpY.
Nebulization of High-Dose Poractant Alfa in Newborn Piglets on Nasal Continuous Positive Airway Pressure Yields Therapeutic Lung Doses of Phospholipids
Authors: Nord Anders , Bianco Federico , Salomone Fabrizio , Ricci Francesca , Schlun Martin , Linner Rikard , Cunha-Goncalves Doris 
Published: November 2020

Objective It is not known how much surfactant must be nebulized to reach a lung dose of phospholipids equivalent to that obtained by the instillation of 200 mg/kg of surfactant. We aimed to assess the feasibility of nebulizing a high-dose of poractant alfa with the eFlow-Neos investigational vibrating-membrane nebulizer in newborn piglets on nasal continuous positive airway pressure (nCPAP) and to determine whether this intervention would yield therapeutic lung doses of phospholipids.
Study Design Twelve 1-day-old piglets on nCPAP received 600 mg/kg of poractant alfa admixed with technetium-99m via nebulization. Six piglets receiving 200 mg/kg of instilled synthetic surfactant served as controls. Lung deposition (percentage of the nominal dose) was determined by gamma scintigraphy, and the phospholipids' lung dose was calculated.
Results The lung dose of phospholipids (mean ± standard deviation [SD]) was 138 ± 96 mg/kg with nebulization, and 172 ± 24 mg/kg with instillation (p = 0.42). Nebulization took 58 ± 12 minutes. The arterial partial pressure of carbon dioxide increased from 6.7 ± 1.1 to 7.2 ± 1.1 kPa during nebulization (p = 0.04). Cerebral oximetry remained stable, and there was no hemodynamic instability.
Conclusion Nebulization was well tolerated, and the mean lung dose of phospholipids was above 100 mg/kg, that is, not different from the instillation group. These experimental findings suggest that it may be feasible to reach therapeutic lung doses of phospholipids by surfactant nebulization during nCPAP.
Key Points
A strong-field approach with realistic wave functions to the above-threshold ionization of Ba+
Authors: Böning B , Abele P , Paufler W , Fritzsche S 
Published: November 2020

Abstract
We study the above-threshold ionization of atoms in intense circularly polarized laser pulses. In order to compute photoelectron energy spectra, we apply the strong-field approximation with different models for the initial state wave function. Specifically, we compare the spectra for singly ionized Barium (Ba+) using hydrogenic wave functions and realistic one-particle wave functions obtained by multiconfiguration Dirac–Hartree–Fock computations, respectively. As a particular example, we discuss the dependence of the photoelectron spectra on the magnetic quantum number m of the initial state and we reproduce the well known m-selectivity in strong-field ionization. Here, we show that the photoelectron spectra exhibit noticeable differences for the two models of the initial state and that the m-selectivity is enhanced when realistic wave functions are used. We conclude that the description of strong-field processes within the strong-field approximation will benefit from a realistic description of the initial atomic state.
Dependency of the structure of a water layer sandwiched by silicon carbide on shear speed and temperature
Authors: Lin Bin , Wei Chibin , Wang Anying , Zou Hongbo , Zhang Xiaofeng , Sui Tianyi , Yan Shuai 
Published: November 2020

Abstract
As a third-generation semiconductor, silicon carbide power devices are expected to be superior to those made of silicon because of their high voltage resistance, low loss, and high efficiency. So understanding the technology for polishing wafers of silicon carbide is important, which includes studying the structure of the liquid on the surface of silicon carbide. Using molecular dynamics based on Lennard-Jones field, the structure of a water film contained within two silicon carbide (〈001〉 and 〈110〉) walls was analyzed, and found that layers of water appear and change depending on the distance between the two walls. When a double-layer water structure forms, it is affected by the temperature and shear velocity. The conclusion is that when the temperature increases or the shear velocity increases, the double-layer water structure easily transforms into a single-layer water structure, and the pressure between the two solid surfaces gradually falls and may even become negative. This phenomenon significantly depends on the distance between the two silicon carbide walls.
Influence of the active TaN/ZrO
x
/Ni memristor layer oxygen content on forming and resistive switching behavior
Authors: Voronkovskii V A , Aliev V S , Gerasimova A K , Perevalov T V , Prosvirin I P , Islamov D R 
Published: November 2020

Abstract
The influence of oxygen content in active zirconium oxide layers on the electrophysical properties of TaN/ZrO
x
/Ni memristors is investigated. The [O]/[Zr] atomic ratio (x) in the oxide layers was varied in the range from 1.56 to 2.0 by changing the partial oxygen pressure during their deposition by ion-beam sputtering deposition. The ZrO
x
film compositions were analyzed using x-ray photoelectron spectroscopy and density functional theory simulations. The multiple resistive switching phenomenon in TaN/ZrO
x
/Ni memristors was found to occur in a certain range of x ≥ 1.78. With the x value decreasing in the oxide layers, the forming voltage of memristors decreased. Furthermore, at the lower edge of x values the switchable range, they no longer required forming. At the same time, as the x value decreased, the memory window (I
ON/I
OFF ratio) also decreased from 5 to 1 order of magnitude due to an increase in the memristor conductivity in the high resistance state. In order to identify the underlying conduction mechanism of TaN/ZrO
x
/Ni memristors, their current–voltage curves in low and high resistance states were analyzed in the temperature range from 250 to 400 K for the samples with x = 1.78 (forming-free) and 1.97 (which required forming). It was found that, for both samples, the conductivity in the low-resistance state is characterized by the trap-free space-charge-limited current (SCLC) model, whereas the conductivity in the high-resistance state is characterized by the trap-mediated SCLC model. The possible origins of structural defects involved in the memristor conductivity and resistive switching are discussed based on the obtained results.
Rearch on the Development Strategy of Qinghai Clean Energy Demonstration Province
Authors: Li Nan , Zhang Haining , Wang Xingnan , Yan Qingyou , Zhu Jingyao , Qin Guangyu 
Published: November 2020

Abstract
With the new round of power system reform and the in-depth advancement of “Internet +” smart energy, the Qinghai Provincial Government has issued a series of related policies and studies on the major requirements of General Secretary Xi Jinping to “make Qinghai an important national new energy industry base”. The development strategy of Qinghai Province’s clean energy demonstration province has become a top priority. This article combines China’s new energy consumption kinetic energy, new models and new forms of energy industry development, summarizes the five bottlenecks in the development of Qinghai’s energy sector based on the actual situation in Qinghai Province, and explores the new energy consumption mechanism of Qinghai Province from four aspects combined with examples. It also puts forward five suggestions on energy policies that promote the development of new energy consumption models and new business forms in Qinghai.
Analysis of the Effect of an AC Three-phase Fault on the Commutation Failure of DC Transmission System
Authors: Yun Yuxin , Li Xing , Zhao Xiaoxiao 
Published: November 2020

Abstract
In AC/DC interconnected systems, the commutation failure of the DC system caused by the AC-side fault is one of the common faults of the inverter. According to the actual engineering parameters, a detailed model of ±660kV Yindong DC transmission project was built using PSCAD/EMTDC simulation tools, and at the same time, an equivalent model of Shandong power grid on the inverter side was also established using physical equivalence-based equivalent methods. On this basis, a simulation analysis was made on the operation of the Yindong DC system when there was a three-phase symmetrical fault in the AC system, providing a reliable reference for the safe and stable operation of the Yindong DC transmission system and other HVDC transmission projects.
Design of DAC for Fluxgate Based on PWM Rectifier
Authors: Li Yunyun , Zhang Yiming , Zhang Chenhao , Wang Xuhong 
Published: November 2020

Abstract
High temperature fluxgate sensor is one of the main sensors in rotary steering logging, which can obtain bit dip information by measuring geomagnetic direction. The use of Digital Analog Converter (DAC) to achieve a closed loop of the fluxgate can effectively improve the measurement accuracy, but the existing DAC chip cannot work in a high temperature environment underground. In order to solve this problem, a design scheme of PWM DAC is proposed. According to the performance index of DAC and the requirements of fluxgate application scenarios, the design points of PWM DAC are discussed, and the circuit implementation scheme is given. Secondly, based on the scheme, a 10 bit PWM DAC with 1 ms adjustment time and 0.5 LSB maximum output ripple is designed, which has passed the simulation and physical verification.
An Optimized Bat Algorithm Combining Local Search and Global Search
Authors: Li Chunting , Lian Zigang , Zhang Tipeng 
Published: November 2020

Abstract
This paper proposes an optimized Bat algorithm combining local search and global search to solve the problem of low accuracy of bat algorithm and easy to fall into local optimum in the later stage. The optimized Bat algorithm enhance the diversity of bat algorithm, improve the search accuracy and convergence speed of bat algorithm, And by solving a variety of different types of functions, it is proved that the optimized bat algorithm that combines local search and global search proposed in this paper is feasible.
Linear Instability Analysis of an Electrified Viscoelastic Liquid Sheet in Compressible Ambient Gas
Authors: Liu Yuxin , Gong Cuicui 
Published: November 2020

Abstract
The linear instability analysis of an electrified viscoelastic liquid sheet exposed to a compressible ambient gas in the presence of a transverse electric field is theoretically investigated. The dispersion relations for the sinuous and varicose mode are obtained. The combined effects of Mach number and Euler number on the instability of the liquid sheet are checked. Our results demonstrate that there is a critical Mach number, below which the growth rate increases and above which the growth rate decreases with the increase of the Mach number. A larger Euler number leads to a smaller critical Mach number. The maximum growth rate nearly stays constant for Mach number that is smaller than the critical Mach number at large Euler numbers. Besides, the electric field enhances the instability of charged electrified liquid sheets, and the maximum growth rate is a linear increasing function of the Euler number. Furthermore, the compressibility of the gas flow will weaken the effect of the electric field on the instability of liquid sheets.
Effect of Prefabricated Layer Structure on Properties of CZTS Thin Films and Solar Cells
Authors: Hao Wenbin , Li Jinze , Li Wei , Zhao Jiansheng , Chen Jianfeng 
Published: November 2020

Abstract
Cu2ZnSnS4 (CZTS) thin films based on single-layer and double-layer prefabricated layer structure were prepared on substrates by two-step method. The influence of prefabricated layer structure on the surface morphology, element composition and photoelectric properties of CZTS thin film was studied. The crystal structure, surface morphology and composition of the films were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), respectively. The experimental results showed that the CZTS thin film with double-layer prefabricated structure had larger grain size, better crystallization and uniform distribution of film components than the CZTS thin film with single-layer prefabricated structure. The conversion efficiency of CZTS solar cells based on the double-layer prefabricated structure increased from 0.25% of the single-layer prefabricated structure to 3.05%. Therefore, the double-layer prefabricated structure CZTS thin film was more suitable as the absorption layer of CZTS thin film solar cells.
Comprehensive Benefit Analysis of Distributed Power Grid Connection
Authors: Yang Changhui , Du Yu 
Published: November 2020

Abstract
Distributed generation can not only improve the utilization level of energy, but also bring huge economic and environmental benefits, which is conducive to the sustainable development of economy and society [1]. With the expansion of distributed generation scale and the implementation of market-oriented trading pilot, it is necessary to accurately evaluate and analyze the economic and environmental benefits of distributed generation, so it is necessary to establish an accurate evaluation model to guide grid companies and government departments to better develop and utilize distributed generation technology. As a whole, the connection between distributed generation and large power grid is helpful to save investment, reduce energy loss and give full play to their respective advantages. From the perspective of distributed generation project, it is helpful for investors to construct cost, invest reasonably and quote accurately. The benefits of distributed generation access to power grid mainly include reducing line loss, reducing power construction cost, reducing electricity price, delaying the construction of distribution and transmission cost, and improving environment and climate.