bluuebunny/crossref_metadata_2025_split huggingface dataset:
Custom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids
Authors: Tong Janelle , Alonso-Caneiro David , Yoshioka Nayuta , Kalloniatis Michael , Zangerl Barbara 
Published: October 2020

AbstractWe aimed to evaluate methods of extracting optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer (GCIPL) thickness measurements over retinal locations corresponding to standard visual field (VF) test grids. A custom algorithm was developed to automatically extract GCIPL thickness measurements from locations corresponding to Humphrey Field Analyser 10-2 and 30-2 test grids over Goldmann II, III and V stimulus sizes from a healthy cohort of 478 participants. Differences between GCIPL thickness measurements based on VF test grids (VF-based paradigms) and the 8 × 8 grid, as per instrument review software, were analyzed, as were impacts of fovea to optic disc tilt and areas over which GCIPL thickness measurements were extracted. Significant differences between the VF-based paradigms and the 8 × 8 grid were observed at up to 55% of locations across the macula, with the greatest deviations at the fovea (median 25.5 μm, 95% CI 25.24–25.72 μm, P < .0001). While significant correlations with fovea to optic disc tilt were noted at up to 33% of locations distributed 6°–8° from the foveal center, there were no marked differences in GCIPL thickness measurements between VF-based paradigms using different stimulus sizes. As such, standard high-density OCT measurement paradigms do not adequately reflect GCIPL measurements at retinal locations tested with standard VF patterns, with the central macular region contributing most to the observed differences and with further correction required for fovea to optic disc tilt. Spatial direction of GCIPL thickness measurements will improve future comparisons of structure and function, thereby improving methods designed to detect pathology affecting the inner retina.
Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels
Authors: Zhang Qianqian , Cai Zexi , Lhomme Marie , Sahana Goutam , Lesnik Philippe , Guerin Maryse , Fredholm Merete , Karlskov-Mortensen Peter 
Published: October 2020

AbstractDyslipidemia is the primary cause of cardiovascular disease, which is a serious human health problem in large parts of the world. Therefore, it is important to understand the genetic and molecular mechanisms that regulate blood levels of cholesterol and other lipids. Discovery of genetic elements in the regulatory machinery is often based on genome wide associations studies (GWAS) focused on end-point phenotypes such as total cholesterol level or a disease diagnosis. In the present study, we add endophenotypes, such as serum levels of intermediate metabolites in the cholesterol synthesis pathways, to a GWAS analysis and use the pig as an animal model. We do this to increase statistical power and to facilitate biological interpretation of results. Although the study population was limited to ~ 300 individuals, we identify two genome-wide significant associations and ten suggestive associations. Furthermore, we identify 28 tentative associations to loci previously associated with blood lipids or dyslipidemia associated diseases. The associations with endophenotypes may inspire future studies that can dissect the biological mechanisms underlying these previously identified associations and add a new level of understanding to previously identified associations.
Diamond step-index nanowaveguide to structure light efficiently in near and deep ultraviolet regimes
Authors: Mahmood Nasir , Mehmood Muhammad Qasim , Tahir Farooq Ahmad 
Published: October 2020

AbstractTwo-dimensional metamaterials, consisting of an array of ultrathin building blocks, offer a versatile and compact platform for tailoring the properties of the electromagnetic waves. Such flat metasurfaces provide a unique solution to circumvent the limitations imposed by their three-dimensional counterparts. Albeit several successful demonstrations of metasurfaces have been presented in the visible, infrared, and terahertz regimes, etc., there is hardly any demonstration for ultraviolet wavelengths due to the unavailability of the appropriate lossless materials. Here, we present diamond as an ultra-low loss material for the near and deep ultraviolet (UV) light and engineer diamond step-index nanowaveguides (DSINs) to achieve full control over the phase and amplitude of the incident wave. A comprehensive analytical solution of step-index nanowaveguides (supported by the numerical study) is provided to describe the underlying mechanism of such controlled wavefront shaping. Due to the ultra-low loss nature of diamond in near and deep UV regimes, our DSINs and metasurfaces designed (from them) exhibit a decent efficiency of ≈ 84% over the entire spectrum of interest. To verify this high efficiency and absolute control over wavefront, we have designed polarization-insensitive meta-holograms through optimized DSINs for operational wavelength λ = 250 nm.
Erwartungen an eine Volltextdatenbank für Abschlussarbeiten aus den Therapiewissenschaften – Eine Online-Befragung
Authors: Griefahn Annika , Lüken Nele , Möller Dirk , Zalpour Christoff 
Published: October 2020

Zusammenfassung
Hintergrund Das Bundesministerium für Bildung und Forschung (BMBF) initiierte 2016 die Open-Access-Initiative. Open Access bedeutet, Wissen online kostenlos freizugänglich zu machen. Dieser Anspruch setzt eine Digitalisierung voraus, die hochschulübergreifend professionelles Wissen öffentlich macht. Dazu passt die Etablierung einer entsprechenden Online-Datenbank.
Ziel Mithilfe einer Online-Befragung die Erwartungen potentieller Nutzer an eine Volltextdatenbank zu untersuchen. Mittels eines Fragebogens sollen Nutzerverhalten, Bedürfnisse, Notwendigkeiten erforscht sowie Ideen, Anregungen, persönliche Einschätzungen und mögliche Vor- und Nachteile erfasst werden.
Methode Durchführung einer Online-Befragung mit 20 Fragen, welche in vier Abschnitte eingeteilt wurden. Geschlossene Fragen wurden deskriptiv ausgewertet, offene Fragen wurden mit der Kernsatzmethode nach Leithäuser und Volmerg (1988) ausgewertet.
Ergebnisse Insgesamt 84,87 % der 337 Befragten zeigten Interesse an einer Volltextdatenbank für Abschlussarbeiten aus den Therapiewissenschaften. Wünsche der Befragten konnten in den Anforderungskatalog für die zu entwickelnde Volltextdatenbank aufgenommen werden. 67,95 % der Befragten würden sich ein Profil in einer Volltextdatenbank anlegen. Die Vorstellung, eine Abschlussarbeit in einem Videoporträt anzulegen, wurde hingegen von 36,50 % als nicht nützlich bewertet.
Schlussfolgerung Anhand der Online-Befragung konnten die Rechercheaktivität und die Wünsche an eine Volltextdatenbank abgefragt werden. Die Nutzerakzeptanz kann erst zu einem späteren Zeitpunkt hinreichend bewertet werden, mithilfe einer Evaluationsstudie.
Synthesis and Crystal Engineering of Rubrene and Its Derivatives
Authors: Douglas Christopher J. , Clapham Margaret L. , Murphy Emma C. 
Published: October 2020

AbstractRubrene (5,6,11,12-tetraphenyltetracene) is a polyacene material that has been well studied throughout its nearly one-hundred year history. Originally found fascinating for its luminescent properties, it has emerged at the forefront for organic electronics due to its particularly high charge carrier mobility for an organic crystal. Despite great interest and its explosion in the literature over the past two decades, the commercial synthesis of rubrene has remained relatively unchanged since its initial discovery in 1926. Several recent studies have reported alternate routes to the rubrene structure with substitutions on the peripheral­ aromatic rings and tetracene core. Substituting in this manner has the potential to improve upon rubrene’s electronic properties. We review the various routes to rubrene and its derivatives and provide a brief overview of the solid-state library available for study. The information gained by comparing the solid-state properties between derivatives offers insight into unpredictable crystallization and polymorphism – complicated issues – which have hindered research into materials applications­ of rubrene. We hope that these insights inspire work in application­-driven synthetic chemistry for future rubrene derivatives.1	Introduction2	Synthesis2.1	Traditional Rubrene Synthesis2.1.1	Recent Applications2.2	Multi-Step Synthesis2.2.1	Historical Routes2.2.2	Diels–Alder Approaches2.2.3	Cross-Coupling Approaches2.2.4	Comparative Synthesis of Perfluororubrene3	Crystal Engineering4	Conclusions and Outlook
Recent Progress towards Organocatalyzed Asymmetric (Hetero)Arene Formation
Authors: Zhu Tingshun , Xu Ke , Wang Ziyuan 
Published: October 2020

AbstractOwing to the importance of arene moieties in organic chemistry, methods for arene construction attract great attention. Besides the traditional substitution strategy from pre-existing arenes, the straightforward formation of arene cores can also provide significant shortcuts towards a wide array of target molecules with different substitution patterns. Among direct arene formation reactions, applying environmentally benign organocatalysis to access arene moieties continues to attract increasing attention. This short review provides a brief summary of recent progress on organocatalyzed de novo (hetero)arene formation and applications in enantioselective synthesis.1 Introduction2 Arene Formation with Non-Covalent Organocatalysts2.1 Arene Formation with Acid Organocatalysts2.2 Arene Formation with Base Organocatalysts2.3 Arene Formation with Hydrogen-Bonding Organocatalysts3 Arene Formation with Covalent Organocatalysts3.1 Arene Formation with Lewis Base Organocatalysts3.1.1 Arene Formation with Secondary Amine Organocatalysts3.1.2 Arene Formation with Tertiary Amine, Tertiary Phosphine and Sulfide Organocatalysts3.1.3 Arene Formation with N-Heterocyclic Carbene Organocatalysts3.2 Arene Formation with Lewis Acid Organocatalysts4 Conclusion
Posterior Tibial Slope Increases Anterior Cruciate Ligament Stress in Bi-Cruciate Retaining Total Knee Arthroplasty: In Vivo Kinematic Analysis
Authors: Klemt Christian , Bounajem Georges , Tirumala Venkatsaiakhil , Xiong Liang , Oganesyan Ruben , Kwon Young-Min 
Published: October 2020

AbstractThe study design involved here is experimental in nature. The resection of the anterior cruciate ligament (ACL) during conventional total knee arthroplasty (TKA) has been considered a potential factor leading to abnormal in vivo knee kinematics. Bi-cruciate retaining (BCR) TKA designs allow the preservation of the ACL with the potential to restore native knee kinematics. This study aimed to investigate the effect of posterior tibial slope (PTS) on stress experienced by the ACL during weight bearing sit-to-stand (STS) and single-leg deep lunge. The ACL elongation patterns were measured in 30 unilateral BCR TKA patients during weight-bearing STS and single-leg deep lunge using a validated dual fluoroscopic tracking technique. The minimum normalized stress within the anteromedial (AM) and posterolateral (PL) bundle of the ACL during weight-bearing STS and single-leg deep lunge was found at a PTS of 3.7 degrees. The maximum AM and PL bundle stresses were observed at a PTS of 8.5 and 9.3 degrees, respectively during STS and at 8.4, and 9.1 degrees, respectively during single-leg deep lunge. There was a significant positive correlation between PTS and stress observed within the AM and PL bundle of the ACL during weight-bearing STS (R
2 = 0.37; p < 0.01; R2
= 0.36; p = 0.01) and single-leg deep lunge (R
2 = 0.42; p < 0.01; R
2 = 0.40; p < 0.01). The study demonstrates that PTS of operated BCR TKA knees has a significant impact on the stress experienced by the preserved ACL during weight-bearing STS and single-leg deep lunge. This suggests that avoiding excessive PTS may be one of the surgical implant alignment factors to consider during surgery to minimize increased loading of the preserved ACL.
Short-Term Outcomes Are Comparable between Robotic-Arm Assisted and Traditional Total Knee Arthroplasty
Authors: Grosso Matthew J. , Li William T. , Hozack William J. , Sherman Matthew , Parvizi Javad , Courtney P. Maxwell 
Published: October 2020

AbstractRobotic-arm assisted total knee arthroplasty (rTKA) was developed to provide for increased accuracy of component placement compared with conventional manual TKA (mTKA). Whether or not rTKA is cost-effective in a bundled payment model has yet to be addressed. The purpose of this comparative study was to evaluate the short-term clinical outcomes of rTKA and mTKA. We retrospectively reviewed a series of 4,086 consecutive primary TKA performed by one of five surgeons across six different hospitals at our institution from January 2016 to December 2018. Outcomes for rTKA cases (n = 581) and mTKA cases (n = 3,505) were compared using unmatched multivariate analysis and a matched cohort. We analyzed 90-day outcomes, episode-of-care claims data, and short form (SF-12) outcome scores to 2 years postoperatively. In matched bivariate analysis, there was no difference in episode-of-care costs, postacute care costs, complications, 90-day readmission rates, emergency department/urgent care visits, reoperations, and mortality between rTKA and mTKA patients (p > 0.05). Matched patients undergoing rTKA did have a shorter hospital length of stay (1.46 vs. 1.80 days, p < 0.001) and decreased rates of discharge to rehabilitation facilities (5.5 vs. 14.8%, p < 0.001). SF-12 scores were clinically similar. Multivariate analysis demonstrated no differences in any 90-day outcome. We conclude that patients undergoing rTKA have comparable costs, 90-day outcomes, and clinically similar improvements in functional outcome scores compared with mTKA patients. Further study is needed to determine whether rTKA will result in improved implant survivorship and long-term functional outcomes (Level of evidence III).
Preoperative Condition of the Patellofemoral Joint Does Not Negatively Impact Surgical Outcomes of Lateral Unicompartmental Knee Arthroplasty in the Short Term
Authors: Fujita Masahiro , Hiranaka Takafumi , Kamenaga Tomoyuki , Tsubosaka Masanori , Nakano Naoki , Hayashi Shinya , Kuroda Ryosuke , Matsumoto Tomoyuki 
Published: October 2020

AbstractThe relationship between patellofemoral joint (PFJ) degeneration and clinical outcomes following lateral unicompartmental knee arthroplasty (UKA) has not been well described thus far. This study aimed to investigate the relationship between the preoperative PFJ condition and postoperative outcomes and the changes in lower-limb and PFJ alignment after lateral UKA. This was a retrospective study including 54 patients (mean age 72.9 years) who underwent lateral UKA for isolated lateral knee osteoarthritis at our institution between March 2013 and January 2019. The Oxford Knee Score (OKS), the Knee Society Score-Knee (KSSK), and Knee Society Score-Function (KSSF), the degree of degeneration, tilting angle and lateral shift of the PFJ, and the hip-knee-ankle angle (HKA) were evaluated pre- and postoperatively. The average follow-up period was 2.8 (range 1–6.1) years. There was a significant improvement in the OKS, KSSK, and KSSF after lateral UKA. Preoperative degeneration of the PFJ did not correlate with the recovery of clinical scores. The degeneration, tilting angle, and lateral shift of the PFJ did not significantly progress following lateral UKA. The HKA was improved after lateral UKA, and there was no correlation between the HKA change and PFJ condition. Postoperative severe valgus knee alignment was associated with a greater tilting angle. Preoperative degeneration of the PFJ did not have a negative impact on postoperative outcomes, and no short-term changes in the degeneration, tilting angle, and lateral shift of the PFJ were observed. Correction of knee-joint alignment did not have a negative impact on the condition of the PFJ.
Knee Arthrofibrosis following Tibial Plateau Fracture Treated with Arthroscopic Lysis of Adhesions with Manipulation
Authors: Middleton Austin H. , Perlewitz Madeline A. , Edelstein Adam I. , Vetter Carole S. 
Published: October 2020

AbstractPosttraumatic arthrofibrosis is a common problem encountered in the orthopaedic setting for which there is no agreement on the optimal management strategy. The literature does not optimally describe the efficacy of arthroscopic lysis of adhesions for arthrofibrosis following tibial plateau fracture. The purpose of this study is to quantify the efficacy of arthroscopic lysis of adhesions with manipulation for the treatment of arthrofibrosis of the knee in patients who previously underwent surgical management of tibial plateau fracture. All patients who underwent arthroscopic lysis of adhesions from a single surgeon since 1999 were retrospectively reviewed. Clinical outcomes were evaluated by flexion, extension, and range of motion (ROM) preoperatively, intraoperatively, and postoperatively at intervals of 1, 4, 8, and 12 weeks, and any additional long-term follow-up. A total of 28 patients who had developed arthrofibrosis following surgical management of a tibial plateau fracture and failed nonsurgical management of knee stiffness were included in this study. There were significant improvements in total ROM following intervention at all time points compared with preoperative values (p < 0.001), with mean improvements of 59.3 degrees intraoperatively, 32.9 degrees (1 week), 37.1 degrees (4 weeks), 41.5 degrees (8 weeks), and 47.6 degrees (12 weeks). There were significant improvements in degrees of knee flexion following intervention at all time points compared with preoperative values (p < 0.001), with mean improvements of 50.8 degrees intraoperatively, 27.3 degrees (1 week), 36.0 degrees (4 weeks), 38.3 degrees (8 weeks), and 43.9 degrees (12 weeks). There were significant increases in degrees of knee extension intraoperatively (8.5 degrees) and at 1 week postoperatively (5.9 degrees) compared with preoperative values (p <0.01). At 12 weeks postoperatively, those who had previously undergone external fixation had significantly greater increases in ROM (p = 0.048). Arthroscopic lysis of adhesions for knee arthrofibrosis following surgical management of tibial plateau fracture significantly improves knee ROM.
What Are the Factors Affecting Total Sleep Time During Video Polysomnography in Infants?
Authors: Paul Grace R. , Hayes Don , Tumin Dmitry , Gulati Ish , Jadcherla Sudarshan , Splaingard Mark L. 
Published: October 2020

Objective The aim of the study is to investigate factors affecting total sleep time (TST) during infant polysomnography (PSG) and assess if <4 hours of TST is sufficient for accurate interpretation.
Study Design Overall, 242 PSGs performed in 194 infants <6 months of chronological age between March 2013 and December 2015 were reviewed to identify factors that affect TST, including age of infant, location and timing of study, presence of medical complexity, and presence of nasal tubes. A continuum of apnea-hypopnea index (AHI) in relation to TST was reviewed. Data were examined in infants who had TST <4 hours and low AHI.
Results Greater TST (p < 0.001) was noted among infants during nocturnal PSGs, at older chronological and post-menstrual ages, and without medical complexity. The presence of nasogastric/impedance probes reduced TST (p = 0.002). Elevated AHIs were identified even in PSGs with TST <4 hours. Short TST may have affected interpretation and delayed initial management in one infant without any inadvertent complications.
Conclusion Clinical factors such as PMA and medical complexity, and potentially modifiable factors such as time of day and location of study appeared to affect TST during infant PSGs. TST < 4 hours can be sufficient to identify high AHI allowing physician interpretation.
Key Points
Balancing the ideals of public participation
Authors: Sjögren Maria 
Published: October 2020

Abstract
Local authorities in western societies increasingly initiate public participation processes despite criticism of these methods. To understand this development calls for in-depth studies of how the goals and values of public participation are articulated in practice. This paper analyzes the discursive legitimation strategies deployed by civil servants in twelve planning meetings for a participatory process aimed at mitigating violence in a Swedish suburb. The study draws on previous research on discursive legitimation, and presents the context-specific strategies of authorization, de-legitimation, cosmology and addressing of values. The analysis highlights that a core discursive tension in this practice arises from its need to seek mandate in the municipal structure, while the value discourses used to legitimize public participation build on a break from traditional bureaucracy. The study contributes to the broader literature on discursive legitimation in contemporary political contexts, with detailed empirical accounts of how a disputed practice is legitimized in interaction.
Epistemic modals in academic English
Authors: Carrió-Pastor María Luisa 
Published: October 2020

Abstract
The hypothesis of this paper is that writers who belong to
different specific fields of knowledge use dissimilar epistemic modals in academic
English. The first specific objective is to identify and contrast the epistemic
modals used in engineering, medicine and linguistics research papers and the second
is to classify the phraseological patterns associated with epistemic modals in these
specific settings. The method was based on a corpus-based approach and, for this
purpose, fifty academic papers in English belonging to the field of engineering,
fifty more from the domain of linguistics and another fifty from medical academic
journals were compiled. The results showed that there were differences in the
epistemic modals used and in the phraseological units composed in engineering,
medicine and linguistics research papers. Finally, conclusions were drawn.
Liquid–liquid phase separation driven compartmentalization of reactive nucleoplasm
Authors: Laghmach Rabia , Potoyan Davit A 
Published: October 2020

Abstract
The nucleus of eukaryotic cells harbors active and out of equilibrium environments conducive to diverse gene regulatory processes. On a molecular scale, gene regulatory processes take place within hierarchically compartmentalized sub-nuclear bodies. While the impact of nuclear structure on gene regulation is widely appreciated, it has remained much less clear whether and how gene regulation is impacting nuclear order itself. Recently, the liquid–liquid phase separation emerged as a fundamental mechanism driving the formation of biomolecular condensates, including membrane-less organelles, chromatin territories, and transcriptional domains. The transience and environmental sensitivity of biomolecular condensation are strongly suggestive of kinetic gene-regulatory control of phase separation. To better understand kinetic aspects controlling biomolecular phase-separation, we have constructed a minimalist model of the reactive nucleoplasm. The model is based on the Cahn–Hilliard formulation of ternary protein–RNA–nucleoplasm components coupled to non-equilibrium and spatially dependent gene expression. We find a broad range of kinetic regimes through an extensive set of simulations where the interplay of phase separation and reactive timescales can generate heterogeneous multi-modal gene expression patterns. Furthermore, the significance of this finding is that heterogeneity of gene expression is linked directly with the heterogeneity of length-scales in phase-separated condensates.