bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Optimal Precursor of El Niño in the GFDL CM2p1 Model
Authors: Yang Zeyun , Fang Xianghui , Mu Mu 
Published: March 2020

AbstractBy applying the principal component analysis‐based particle swarm optimization algorithm, the conditional nonlinear optimal perturbation is firstly calculated in the Geophysical Fluid Dynamics Laboratory Climate Model version 2p1 (GFDL CM2p1) to identify the optimal precursor (OPR) of El Niño. Specifically, through optimizing the initial perturbation, the OPRs that have the largest nonlinear evolution (i.e., mature state of El Niño) for two reference states are obtained, which are then confirmed according to the validation test. The results indicate that both OPRs show positive sea surface temperature perturbation in the west (2°N–2°S, 135.5–165.5°E). For the subsurface component, they exhibit positive subsurface temperature perturbation (STP) in the whole mixed layer of the west and negative STP in the upper layer of the east (i.e., 0‐ to 85‐m depth, 2°N–2°S, 79.5–109.5°W). Further analyses of the evolution of the sea surface temperature perturbation, STP, and surface wind perturbation suggest that the development of the OPRs in the model is consistent with the recognized mechanism for El Niño‐Southern Oscillation development, that is, through the Bjerknes positive feedback. The results indicate that the model can realistically capture the dominant processes for El Niño development, and the principal component analysis‐based particle swarm optimization algorithm is a practical solution for calculating the conditional nonlinear optimal perturbation in a complicated numerical model such as the GFDL CM2p1. They both shed a light on guiding the realistic observing systems.
Calibration of the Falcon Solid‐state Energetic Electron Detector (SEED)
Authors: Cress R. , Maldonado C. A. , Coulter M. , Haak K. , Balthazor R. L. , McHarg M. G. , Barton D. , Greene K. , Lindstrom C. D. 
Published: March 2020

AbstractThe Falcon Solid‐state Energetic Electron Detector (FalconSEED) is an energetic charged particle sensor that has been developed and tested at the United States Air Force Academy in an effort to monitor electron flux across the energy range of 14 to 145 keV in geosynchronous orbit. This sensor has been developed to complement ongoing efforts by the Air Force Research Laboratory to advance a comprehensive space environment sensor suite, Compact Environmental Anomaly Sensor (CEASE3), for anomaly resolution. In addition, FalconSEED is intended to demonstrate the ability to operate a radiation sensor based on predominantly commercial off the shelf components in the geosynchronous environment. This paper describes the design, development, and calibration of FalconSEED. The electron energy spectrum of interest for the FalconSEED sensor is 14 to 145 keV, and is intended to supplement data acquired from the CEASE3 instrument for anomaly resolution. The calibrations at the Space Atmospheric Research Center at the United States Air Force Academy and Kirtland Air Force Base were used to first establish the conversion between histogram bin number and deposited energy in the sensor, and second have been used to determine the geometric factor as a function of energy. The FalconSEED will be integrated as a science payload on the Space Test Program Satellite‐6 which also includes the first flight of the CEASE3 instrument and is scheduled to launch in 2021.
Cenozoic Exhumation of the Qilian Shan in the Northeastern Tibetan Plateau: Evidence From Low‐Temperature Thermochronology
Authors: Wang Weitao , Zheng Dewen , Li Chaopeng , Wang Ying , Zhang Zhuqi , Pang Jianzhang , Wang Yang , Yu Jingxing , Wang Yizhou , Zheng Wenjun , Zhang Huiping , Zhang Peizhen 
Published: March 2020

AbstractThe growth of the Tibetan Plateau is related to the Cenozoic India‐Eurasia plate collision; however, its growth and evolution to its present margins remain matters of debate. The Qilian Shan, which is located along the northeastern margin of the Tibetan Plateau, plays a central role in understanding the outward growth of the plateau. In this paper, we present new low‐temperature thermochronologic data from the hanging wall of the Huangcheng‐Shuangta fault (HSF) and the Lenglongling west region in the eastern part of the Qilian Shan. Cooling ages and thermal history modeling show increased exhumation rates at ~15 Ma along the HSF and ~5 Ma in the Lenglongling west region. We suggest that the middle Miocene beginning of rapid exhumation reflects the expansion of the larger Qilian Shan driven by thrust fault systems. The fast Pliocene exhumation may have been related to left‐lateral motion on the Haiyuan fault during the late stage of orogenic development. Post‐Miocene episodes of rapid exhumation in the eastern Qilian Shan are similar to those in other regions on the northeastern margin of the Tibetan Plateau, suggesting that middle to late Miocene initiation or acceleration of crustal shortening occurred along this margin.
Detrital Thermochronology Reveals Major Middle Miocene Exhumation of the Eastern Flank ofthe Andes That Predates the PampeanFlat Slab (33°–33.5°S)
Authors: Lossada A. C. , Hoke G. D. , Giambiagi L. B. , Fitzgerald P. G. , Mescua J. F. , Suriano J. , Aguilar A. 
Published: March 2020

AbstractThe Cordón del Plata and Cordón del Portillo (32.6°–33.8°S) are the portions of the Frontal Cordillera that straddle the transition zone between the Pampean flat‐slab subduction segment to the north and the normal subduction segment to the south. A complete understanding of how the Frontal Cordillera developed is necessary in order to evaluate different tectonic models for the Andes along with their relation to subduction dynamics and contractional upper‐crustal deformation. Detrital apatite fission track thermochronology of modern river sediments that drain the eastern and western slopes of the Cordón del Plata and the northern Cordón del Portillo provides constraints on regional exhumation histories. AFT data from each catchment typically contain multiple age peaks, but all have a prominent 15.3–17 Ma age peak. One catchment, the Las Tunas River has a unimodal distribution at 17.0 ± 1.1 Ma, with a confined track length distribution indicative of rapid cooling at that time. These results, combined with provenance analysis in the adjacent Cacheuta Basin, indicate significant early to middle Miocene (~16 Ma) exhumation in the Cordón del Plata and the northern sector of the Cordón del Portillo. Exhumation related to rock uplift occurred prior to the ~11 Ma onset of a flat slab geometry at these latitudes, but immediately after the main east vergent contractional event in the adjacent Principal Cordillera. Such Frontal Cordillera exhumation fits in an eastward, youngest to the foreland sequence of deformation of the different morphostructural Andean units at ~33°–34°S, arguing against the recently proposed west vergent orogenic system at these latitudes.
Dynamic Pore‐Scale Dissolution by CO2‐Saturated Brine in Carbonates: Impact of Homogeneous Versus Fractured Versus Vuggy Pore Structure
Authors: Yang Yongfei , Li Yingwen , Yao Jun , Iglauer Stefan , Luquot Linda , Zhang Kai , Sun Hai , Zhang Lei , Song Wenhui , Wang Zhiyu 
Published: March 2020

AbstractLimestone pore structure strongly influences dissolution and associated reactive transport. These effects are critical in limestone diagenesis and but also in engineering operations such as carbon capture and storage (CCS). However, detailed studies on how CO2‐enriched (acidic) brine changes this pore structure at relevant reservoir storage conditions are very limited. Thus, to provide further quantitative information and more fundamental understanding about these key processes, we studied the dissolution patterns of a homogeneous, a fractured, and a vuggy limestone when flooded with CO2‐saturated brine at representative storage conditions. The pore structured of these limestones showed drastically different responses to the acidic brine flood. As such, preferential channels surrounded by branched channels were formed in the homogeneous sample, while fractures became the main flow path in the fractured sample. In contrast, only one dominant channel formed in the vuggy sample, which resulted in a sharp permeability increase. These dissolution patterns reflect the associated Damköhler number, which significantly lower in the homogeneous, representing uniform dissolution. However, after injecting sufficient reactive fluid (1,000 PV), this uniform dissolution pattern transformed into a single preferential channel growth. Moreover, we conclude that increasing complexity of the pore geometry leads to more nonuniform dissolution. These dissolution patterns indicate the effect of initial pore structure on preferential channel growth and reaction transport. Our work provides key fundamental data for further quantifying limestone dissolution patterns in CCS, indicating that the CO2 injection may cause the reactivation of geological faults and damage around wellbore, thus aids in the implementation of industrial‐scale CCS.
Subannual Streamflow Responses to Rainfall and Snowmelt Inputs in Snow‐Dominated Watersheds of the Western United States
Authors: Hammond John C. , Kampf Stephanie K. 
Published: March 2020

AbstractStreamflow generation in mountain watersheds is strongly influenced by snow accumulation and melt, and multiple studies have found that snow loss leads to earlier snowmelt timing and declines in annual streamflow. However, hydrologic responses to snow loss are heterogeneous, and not all areas experience streamflow declines. This research examines whether streamflow generation is different for rainfall versus snowmelt inputs. We compiled a sample of 57 small U.S. Geological Survey watersheds in the western United States containing a Natural Resource Conservation Service Snow Telemetry site and having ratios of mean annual peak snow water equivalent to precipitation ratios >0.25. Daily streamflow was separated into quickflow and baseflow using a digital filter, and quickflow was then divided into quickflow response intervals using thresholds in quickflow slope. Each quickflow response interval was categorized by its fraction of input from snowmelt. Most sites exhibited two streamflow generation peaks each year, with one peak in the winter when runoff efficiency is greatest, and the second in the spring during peak snowmelt input. On average, study watersheds were dominated by snowmelt inputs (70%), and snowmelt and mixed inputs usually generated greater streamflow than rainfall because of higher inputs and longer durations. However, rainfall produced high streamflow generation in winter, when watersheds have their highest runoff efficiency (81%) across all input types. We demonstrate that while snowmelt is important for streamflow generation due to high input over long periods, increases in rain and mixed input during wet winter periods can countervail tendencies for reduced streamflow with declining snowpacks.
Toward the Acoustic Detection of Two‐Phase Flow Patterns and Helmholtz Resonators in Englacial Drainage Systems
Authors: Podolskiy Evgeny A. 
Published: March 2020

AbstractPassive acoustic monitoring has revolutionized the characterization of industrial processes and the acoustic wavefield in various environments. However, cryospheric acoustic phenomena remain largely unknown, especially at medium and small scales. Furthermore, the englacial drainage system is poorly documented, even though it is fundamental for understanding water routing through the glacier body. Here I present the first‐of‐its‐kind in situ records of periodic or sustained acoustic signals generated by water drainage through crevasses at the calving front of a glacier, in this case a Greenlandic tidewater glacier. The generative mechanisms of gurgling and bubbling noise are explained as flow‐induced sounds that are excited by intermittent air‐water two‐phase flow and Helmholtz resonance, respectively. This paper demonstrates that there is the tremendous potential to study near‐surface glacier systems using acoustic methods and detect different flow patterns in englacial conduits from their acoustic signatures, both of which can significantly advance our understanding of glaciological processes.
The prognostic significance of immune microenvironment in breast ductal carcinoma in situ
Authors: Toss Michael S. , Abidi Asima , Lesche Dorothea , Joseph Chitra , Mahale Sakshi , Saunders Hugo , Kader Tanjina , Miligy Islam M. , Green Andrew R. , Gorringe Kylie L. , Rakha Emad A. 
Published: March 2020

AbstractBackgroundThe role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS.MethodsA well characterised DCIS cohort (n = 700) with long-term follow-up comprising pure DCIS (n = 508) and DCIS mixed with invasive carcinoma (IBC;n = 192) were stained immunohistochemically for CD20, CD3, CD4, CD8, FOXP3, PD1 and PDL1. Copy number variation and TP53 mutation status were assessed in a subset of cases (n = 58).ResultsCD3+ lymphocytes were the predominant cell subtype in the pure DCIS cohort, while FOXP3 showed the lowest levels. PDL1 expression was mainly seen in the stromal TILs. Higher abundance of TILs subtypes was associated with higher tumour grade, hormone receptor negativity and HER2 positivity. Mutant TP53 variants were associated with higher levels of stromal CD3+, CD4+ and FOXP3+ cells. DCIS coexisting with invasive carcinoma harboured denser stromal infiltrates of all immune cells and checkpoint proteins apart from CD4+ cells. Stromal PD1 was the most differentially expressed protein between DCIS and invasive carcinoma (Z = 5.8,p < 0.0001). Dense TILs, stromal FOXP3 and PDL1 were poor prognostic factors for DCIS recurrence, while dense TILs were independently associated with poor outcome for all recurrences (HR = 7.0;p = 0.024), and invasive recurrence (HR = 2.1;p = 0.029).ConclusionsImmunosuppressive proteins are potential markers for high risk DCIS and disease progression. Different stromal and intratumoural lymphocyte composition between pure DCIS, DCIS associated with IBC and invasive carcinoma play a potential role in their prognostic significance and related to the underlying genomic instability. Assessment of overall TILs provides a promising tool for evaluation of the DCIS immune microenvironment.
In silico mining and functional analysis of AP2/ERF gene in Withania somnifera
Authors: Tripathi Sandhya , Srivastava Yashdeep , Sangwan Rajender Singh , Sangwan Neelam Singh 
Published: March 2020

AbstractWithania somnifera owing to its strong and remarkable stress tolerance property is a reliable candidate for the determination of genes involved in mechanism of adaption/tolerance of various stress conditions. 187 AP2/ERF gene related transcripts (GRTs) were identified during comprehensive search in W. somnifera transcriptome repertoire. Major hits in homology search were observed from the model plant Arabidopsis and members of Solanaceae family. Cloning, expression analysis of the gene and genetic transient transformation with the gene (WsAP2) were performed to predict its functional role in planta. Enhanced expression of some of the pathway genes for terpenoid biosynthesis was observed in transformed tissues in comparison to the control tissues. It is speculated that WsAP2 gene crucially regulates the expression of GGPPS gene in addition to the regulation of other important genes of terpenoid pathway via induction of expression of other genes such as HMGR, CAS, DXS and DXR. To the best of our knowledge, this is the first report representing detailed study of AP2/ERF gene family in W. somnifera. It is also suggested from the study that gene might have role in eliciting responses to combat stress and attribute the strong stress tolerant property associated with the plant.
Performance Differences of Hexavalent Chromium Adsorbents Caused by Graphene Oxide Drying Process
Authors: Lee JinHyeong , Kim Hee-Gon , Lee Jung-Hyun , Cho So-Hye , Jung Kyung-Won , Lee Seung Yong , Choi Jae-Woo 
Published: March 2020

AbstractIn this study, the influence of drying conditions on amine (−NH3) functionalization of graphene oxide (GO) was evaluated, and the hexavalent chromium (Cr(VI)) adsorption efficiency of the prepared materials was compared. 3-[2-(2-aminoehtylamino) ethylamino]propyl-trimethoxysilane (3N) was used for amine functionalization. The synthesized materials were analyzed by SEM, BET, TGA, XPS, and EA. TGA results showed that the solution-GO (SGO) was functionalized by more 3N molecules than freeze-dried GO (FDGO) and oven-dried GO (ODGO). Additionally, XPS analysis also showed that the ratio of N/C and Si/C was relatively high in SGO than FDGO and ODGO. The maximum adsorption capacity of SGO, FDGO, and ODGO for Cr(VI) was 258.48, 212.46, and 173.45 mg g−1, respectively. These results indicate that it is better to use SGO without drying processes for efficient amine functionalization and Cr(VI) removal. However, when the drying process is required, freeze-drying is better than oven-drying.
CircRNA_0058063 functions as a ceRNA in bladder cancer progression via targeting miR-486-3p/FOXP4 axis
Authors: Liang Haote , Huang Hang , Li Yeping , Lu Yongyong , Ye Tingyu 
Published: March 2020

Abstract
Emerging evidence has uncovered critical regulatory roles of circular RNAs (circRNAs) function as dynamic scaffolding molecules in tumorigenesis and progression. However, the aberrant expression and clinical significance of hsa_circ_0058063 (circRNA_0058063) in bladder cancer (BC) remain poorly understood. circRNA expression was analyzed via a microarray in cancerous tissue and non-carcinoma tissues. Luciferase reporter assays and RNA immunoprecipitation (RIP) were both conducted to uncover the function of circRNA_0058063 in BC. circRNA_0058063 was overexpressed in BC tissues compared with adjacent normal tissues. Knockdown of circRNA_0058063 dramatically decreased cell proliferation and invasion, and promoted apoptosis in 5637 and BIU-87 cell lines. Furthermore, mechanistic investigations showed that circRNA_0058063 and FOXP4 could directly bind to miR-486-3p, demonstrating that circRNA_0058063 regulated FOXP4 expression by competitively binding to miR-486-3p. Taken together, circRNA_0058063 functions by sponging miR-486-3p in BC progression, which could act as a new biomarker and further developed to be a therapeutic target in BC.
The Adaptation to Mandarin-Accented English by Older, Hearing-Impaired Listeners Following Brief Exposure to the Accent
Authors: Hau Jutta A. , Holt Colleen M. , Finch Sue , Dowell Richard C. 
Published: March 2020

Purpose
The language processing of Mandarin-accented English (MAE) by older hearing-impaired (OHI), older normally hearing (NH), and younger NH listeners was explored. We examined whether OHI adults have more difficulty than NH listeners in recognizing and adapting to MAE speech productions after receiving brief training with the accent.

Method
Talker-independent adaptation was evaluated in an exposure training study design. Listeners were trained either by four MAE talkers or four Australian English talkers (control group) before listening to sentences presented by a novel MAE talker. Speech recognition for both the training sentences and the experimental sentences were compared between listener groups and between the training accents.

Results
Listeners in all three groups (OHI, older NH, younger NH) who had been trained by the MAE talkers showed higher odds of speech recognition than listeners trained by the Australian English talkers. The OHI listeners adapted to MAE to the same degree as the NH groups despite returning lower overall odds of recognizing MAE speech.

Conclusions
Older listeners with mild-to-moderate hearing loss were able to benefit as much from brief exposure to MAE as did the NH groups. This encouraging result suggests that OHI listeners have access to and can exploit the information present in a relatively brief sample of accented speech and generalize their learning to a novel MAE talker.
Vowel Acoustics and Speech Intelligibility in Young Adults With Down Syndrome
Authors: Carl Micalle , Kent Raymond D. , Levy Erika S. , Whalen D. H. 
Published: March 2020

Purpose
Speech production deficits and reduced intelligibility are frequently noted in individuals with Down syndrome (DS) and are attributed to a combination of several factors. This study reports acoustic data on vowel production in young adults with DS and relates these findings to perceptual analysis of speech intelligibility.

Method
Participants were eight young adults with DS as well as eight age- and gender-matched typically developing (TD) controls. Several different acoustic measures of vowel centralization and variability were applied to tokens of corner vowels (/ɑ/, /æ/, /i/, /u/) produced in common English words. Intelligibility was assessed for single-word productions of speakers with DS, by means of transcriptions from 14 adult listeners.

Results
Group differentiation was found for some, but not all, of the acoustic measures. Low vowels were more acoustically centralized and variable in speakers with DS than TD controls. Acoustic findings were associated with overall intelligibility scores. Vowel formant dispersion was the most sensitive measure in distinguishing DS and TD formant data.

Conclusion
Corner vowels are differentially affected in speakers with DS. The acoustic characterization of vowel production and its association with speech intelligibility scores within the DS group support the conclusion of motor control deficits in the overall speech impairment. Implications are discussed for effective treatment planning.
Lexical Repetition Properties of Caregiver Speech and Language Development in Children With Cochlear Implants
Authors: Wang Yuanyuan , Jung Jongmin , Bergeson Tonya R. , Houston Derek M. 
Published: March 2020

Purpose
Early language input plays an important role in child language and cognitive development (e.g., Gilkerson et al., 2018; Hart & Risley, 1995). In this study, we examined the effects of child's hearing status on lexical repetition properties of speech produced by their caregivers with normal hearing (NH). In addition, we investigated the relationship between maternal lexical repetition properties and later language skills in English-learning infants with cochlear implants (CIs).

Method
In a free-play session, 17 mothers and their prelingually deaf infants who received CIs before 2 years of age (CI group) were recorded at two post-CI intervals: 3 and 6 months postactivation; 18 hearing experience–matched infants with NH and their mothers and 14 chronological age–matched infants with NH group and their mothers were matched to the CI group. Maternal speech was transcribed from the recordings, and measures of maternal lexical repetition were obtained. Standardized language assessments were administered on children with CIs approximately two years after CI activation.

Results
The findings indicated that measures of lexical repetition were similar among the three groups of mothers, regardless of the hearing status of their infants. In addition, lexical repetition measures were correlated with later language skills in infants with CIs.

Conclusions
Infants with CIs receive the language input that contains similar lexical repetition properties as that in the speech received by their peers with NH, which is likely to play an important role in child speech processing and language development. These findings provide the knowledge for professionals to coach parents to implement specific language intervention strategies to support language development in infants with hearing loss.

Supplemental Material

https://doi.org/10.23641/asha.11936322