bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of prophylactic selective arterial embolization for renal angiomyolipomas: identifying predictors of 50% volume reduction
Authors: Hongyo Hidenari , Higashihara Hiroki , Osuga Keigo , Kashiwagi Eiji , Kosai Shinya , Nagai Keisuke , Tanaka Kaishu , Ono Yusuke , Ujike Takeshi , Uemura Motohide , Imamura Ryoichi , Nonomura Norio , Tomiyama Noriyuki 
Published: November 2020

Abstract
Background
Transcatheter arterial embolization (TAE) has been widely performed for renal angiomyolipomas (AMLs) as prophylaxis or emergency treatment. On the other hand, mammalian target of rapamycin (mTOR) inhibitors have recently been used for tuberous sclerosis (TSC)-related AMLs, and no comparison between the effectiveness of mTOR inhibitors versus prophylactic selective TAE has yet been performed.
Therefore, the purpose of this study was to evaluate the efficacy of TAE for AML tumor volume reduction and predictors of tumor volume decrease over 50%, with reference to the EXIST-2 trial.

Methods
A total of 44 patients who underwent 48 prophylactic embolization procedures for 50 AMLs in a single institution between 2004 and 2018 were included. Indications for TAE of AMLs were tumor size ≥4 cm or aneurysm ≥5 mm in diameter on contrast-enhanced computed tomography (CECT). Microspheres, ethanol, and micro-coils were used as embolic agents. The percentage volume reduction from before TAE to the minimum volume during follow-up after TAE was calculated, and predictors for 50% volume reduction were identified by univariate and multivariate binary logistic regression analyses.

Results
The technical success rate was 100% (50 of 50). No severe acute complications related to the procedure were encountered. Tumor volume reduction of ≥50% was observed in 35/50 AMLs. There was a significant difference in the rate of tumor volume reduction of 50% between the presence and absence of an aneurysm ≥5 mm and between tumor diameter ≥ 70 mm and < 70 mm on univariate analysis. On multivariate analysis, tumor diameter < 70 mm was the only independent predictor of significant tumor volume reduction after TAE.

Conclusion
Prophylactic selective TAE for AMLs has good tumor-reduction effects, especially for AMLs with tumor diameter < 70 mm.
Spray Characterization of Aerosol Delivery Systems for Use in Stored Product Facilities
Authors: Asuncion Fei Xyza B. , Brabec Daniel L. , Casada Mark E. , Maghirang Ronaldo G. , Arthur Frank H. , Campbell James F. , Zhu Kun Yan , Martin Daniel E. 
Published: November 2020

HighlightsHandheld sprayers generated larger droplets and wider droplet size distributions than compressed gas sprayers.Sprayers with higher pressure and nozzles with wider spray angle produced smaller droplets.Droplet size distribution influenced spray coverage, mass concentration, deposition, and sprayer efficacy.The handheld sprayers had less spray coverage and efficiency than the compressed gas sprayers.The deposition at different locations was influenced by the volume of the space, aerosol dosage, and spray time.Abstract. Aerosol insecticides, including pyrethrins, can be used as methyl bromide replacements to control stored product insects inside flour mills and rice mills. The effectiveness of aerosol application for insect control requires knowing the spray characteristics of the equipment to be used and understanding factors that influence the effectiveness of insecticide application. The objectives of this study, as part of efforts to optimize aerosol applications, were to evaluate the characteristics of six aerosol delivery systems (two handheld sprayers and compressed gas sprayer systems fitted with two types of manifolds and two types of nozzles), estimate the dispersion and deposition of aerosol in a simulated stored product facility, and determine how the dispersion and deposition are affected by the characteristics of the sprayers. Results showed that the spray systems differed significantly in spray characteristics. The compressed gas sprayers generated significantly smaller droplets, more uniform droplet size distribution, and better spray coverage than the handheld sprayers. The ellipsoidal nozzle produced significantly smaller droplets than the circular nozzle. While the type of manifold had no significant effect on deposition, higher aerosol dosage and spray time resulted in significantly higher deposition. Results of this study will be used to improve spray techniques for stored product insect control, to validate computational fluid dynamics modeling of aerosol application, and to improve testing methods in large-scale spray testing inside commercial facilities. Keywords: APS spectrometer, Droplet size distribution, HELOS KR-Vario, Mass deposition, Spray characteristics, Spray nozzles.
Program-controlled single soliton microcomb source
Authors: Wang Xinyu , Xie Peng , Wang Weiqiang , Wang Yang , Lu Zhizhou , Wang Leiran , Chu Sai T. , Little Brent E. , Zhao Wei , Zhang Wenfu 
Published: November 2020

Soliton microcombs (SMCs) are spontaneously formed in a coherently pumped high-quality microresonator, which provides a new tool for use as an on-chip frequency comb for applications of high-precision metrology and spectroscopy. However, generation of SMCs seriously relies on advanced experimental techniques from professional scientists. Here, we experimentally demonstrate a program-controlled single SMC source where the intracavity thermal effect is timely balanced using an auxiliary laser during single SMC generation. The microcomb power is adopted as the criteria for microcomb states discrimination and a forward and backward thermal tuning technique is employed for the deterministic single SMC generation. Further, based on a closed-loop control system, the repetition rate stability of the SMC source improved more than 20 times and the pump frequency can be continuously tuned by simply changing the operation temperature. The reliability of the SMC source is verified by consecutive 200 generation trials and maintaining over 10 h. We believe the proposed SMC source will have significant promising influences in future SMC-based application development.
Time to treatment disruption in children with HIV-1 randomized to initial antiretroviral therapy with protease inhibitors versus non-nucleoside reverse transcriptase inhibitors
Authors: Yin Dwight E. , Ludema Christina , Cole Stephen R. , Golin Carol E. , Miller William C. , Warshaw Meredith G. , McKinney Ross E. ,   on behalf of the PENPACT-1 (PENTA 9 / PACTG 390) Study Team
Published: November 2020

Background
Choice of initial antiretroviral therapy regimen may help children with HIV maintain optimal, continuous therapy. We assessed treatment-naïve children for differences in time to treatment disruption across randomly-assigned protease inhibitor versus non-nucleoside reverse transcriptase inhibitor-based initial antiretroviral therapy.

Methods
We performed a secondary analysis of a multicenter phase 2/3, randomized, open-label trial in Europe, North and South America from 2002 to 2009. Children aged 31 days to <18 years, who were living with HIV-1 and treatment-naive, were randomized to antiretroviral therapy with two nucleoside reverse transcriptase inhibitors plus a protease inhibitor or non-nucleoside reverse transcriptase inhibitor. Time to first documented treatment disruption to any component of antiretroviral therapy, derived from treatment records and adherence questionnaires, was analyzed using Kaplan-Meier estimators and Cox proportional hazards models.

Results
The modified intention-to-treat analysis included 263 participants. Seventy-two percent (n = 190) of participants experienced at least one treatment disruption during study. At 4 years, treatment disruption probabilities were 70% (protease inhibitor) vs. 63% (non-nucleoside reverse transcriptase inhibitor). The unadjusted hazard ratio (HR) for treatment disruptions comparing protease inhibitor vs. non-nucleoside reverse transcriptase inhibitor-based regimens was 1.19, 95% confidence interval [CI] 0.88–1.61 (adjusted HR 1.24, 95% CI 0.91–1.68). By study end, treatment disruption probabilities converged (protease inhibitor 81%, non-nucleoside reverse transcriptase inhibitor 84%) with unadjusted HR 1.11, 95% CI 0.84–1.48 (adjusted HR 1.13, 95% CI 0.84–1.50). Reported reasons for treatment disruptions suggested that participants on protease inhibitors experienced greater tolerability problems.

Conclusions
Children had similar time to treatment disruption for initial protease inhibitor and non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy, despite greater reported tolerability problems with protease inhibitor regimens. Initial pediatric antiretroviral therapy with either a protease inhibitor or non-nucleoside reverse transcriptase inhibitor may be acceptable for maintaining optimal, continuous therapy.
Exploring the Transition to Eudaimonic Tourism: A Case Study of Bali
Authors: Simandjuntak Djisman , Desfiandi Alvin , Lukas Erica , Setiawati Isti , Sabrina Nakita , Makalew Stanley 
Published: November 2020

<p>Growing population with rising income, advances in information and transportation technologies, preventive medicine, moderated nationalism that translate into less restrictive border measures against people flows have combined to fuel a durable progressive growth in tourism, domestic and international. As tourism grows, carrying capacity is stretched or even overstretched in some places and industries. The overcrowding of a destination in the latter’s life cycle is familiar to popular tourist sites. Energy consumption, CO2 emission, non-degradable and toxic wastes, biodiversity loss and loss of cultural diversity add to the downside of growing tourism. We doubt the inclusivity and sustainability of the current dominant design of tourism in developing economies such as Indonesia. A shift toward more eudaimonic tourism is needed. The innovative elements of eudaimonia include geographical treasure, biodiversity, and local deep culture. Indonesia is well endowed with peculiar geographical resources which in turn result in rich biodiversity. A long history of migration has also accumulated Indonesia’s cultural diversity. Bali offers an imperfect road to eudaimonic tourism as will be discussed as evidence that the shift away from exclusive and unsustainable tourism to a more inclusive and sustainable one is a realistic option.</p><p><strong> </strong></p><p><strong>Keywords:</strong> eudaimonic; tourism; inclusivity; sustainability<strong></strong></p>
Cellular Angiofibroma Presenting as a Subepithelial Rectal Mass
Authors: Bloom Jennifer , Jordan Eric , Baratta Vanessa M. , Zhang Xuchen , Saha Atin , Yavorek George , Kurbatov Vadim 
Published: November 2020

ABSTRACT
A very rare case of cellular angiofibroma arising from the rectum in a 62-year-old man with a normal colonoscopy 2 years earlier is reported. To our knowledge, this is the first such case reported in the literature. The tumor was transanally excised with clear margins, and the patient had no postoperative complications. It is key to accurately differentiate this lesion from other subepithelial rectal tumors and more aggressive genital soft tissue tumors because clinical management varies. We performed a review of clinical records and pathology as well as an extensive literature review.
The Spectrum of Gastrointestinal Symptoms in Patients With Coronavirus Disease-19: Predictors, Relationship With Disease Severity, and Outcome
Authors: Ghoshal Uday C. , Ghoshal Ujjala , Mathur Akash , Singh Ratender K. , Nath Alok , Garg Atul , Singh Dharamveer , Singh Sanjay , Singh Jasmeet , Pandey Ankita , Rai Sushmita , Vasanth Shruthi , Dhiman Radha Krishan 
Published: November 2020

INTRODUCTION:
We prospectively studied the frequency, spectrum, and predictors of gastrointestinal (GI) symptoms among patients with coronavirus disease-19 (COVID-19) and the relationship between GI symptoms and the severity and outcome.

METHODS:
Consecutive patients with COVID-19, diagnosed in a university hospital referral laboratory in northern India, were evaluated for clinical manifestations including GI symptoms, their predictors, and the relationship between the presence of these symptoms, disease severity, and outcome on univariate and multivariate analyses.

RESULTS:
Of 16,317 subjects tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in their oropharyngeal and nasopharyngeal swabs during April–May 2020, 252 (1.5%) were positive. Of them, 208 (82.5%) were asymptomatic; of the 44 symptomatic patients, 18 (40.9%) had non-GI symptoms, 15 (34.1%) had a combination of GI and non-GI symptoms, and 11 (25.0%) had GI symptoms only. Thirty-three had mild-to-moderate disease, 8 severe, and 5 critical. Five patients (1.98%) died. On multivariate analysis, the factors associated with the presence of GI symptoms included the absence of contact history and presence of non-GI symptoms and comorbid illnesses. Patients with GI synptoms more often had severe, critical illness and fatal outcome than those without GI symptoms.

DISCUSSION:
Eighty-two percent of patients with COVID-19 were asymptomatic, and 10.3% had GI symptoms; severe and fatal disease occurred only in 5% and 2%, respectively. The presence of GI symptoms was associated with a severe illness and fatal outcome on multivariate analysis. Independent predictors of GI symptoms included the absence of contact history, presence of non-GI symptoms, and comorbid illnesses.

JOURNAL/cltg/04.03/01720094-202012000-00003/inline-graphic1/v/2023-10-30T213551Z/r/image-tiff
El estatus de arte del CG-art desde un modo de existencia de tipo-natural
Authors: Arriagada Beltrán Leonardo Salvador 
Published: November 2020

La introducción de las redes generativas antagónicas en el mundo del arte ha revitalizado la clásica pregunta: ¿puede una máquina crear arte? Estos algoritmos requieren una mínima intervención humana para funcionar, por lo que sus creaciones se consideran CG-art. En esta clase particular de arte los computadores no son una herramienta al servicio humano, sino un agente creativo autónomo. Por otro lado, estudios cognitivos recientes han demostrado que las personas son escépticas ante la idea de que una máquina pueda crear arte. Este artículo tiene como objetivo mostrar que el CG-art no puede excluirse arbitrariamente del dominio artístico. Para ello se utiliza la distinción hecha por Dickie entre teorías del arte de tipo natural y cultural. Luego, utilizando el concepto función de estatus de Searle, se propone considerar al arte como un fenómeno independiente del lenguaje. Complementando ambos enfoques sostengo que, la teoría idónea para explicar el fenómeno del CG-art es del tipo natural. Esto implica que la sociedad no puede negar el carácter de arte a estas creaciones algorítmicas. Así, la idea de que las máquinas pueden crear arte es fortalecida.
Palabras clave: CG-art, teoría de arte, filosofía social, Searle, función de estatus
Effectiveness of a Hungarian peer education handwashing programme in primary and secondary schools
Authors: Molnár ZS. , Varga L. , Gyenes G. , Lehotsky Á. , Gradvohl E. , Lukács Á.J. , Füzi R.A. , Gézsi A. , Falus A. , Feith H.J. 
Published: November 2020

AbstractPurposeProper handwashing helps prevent the spread of communicable diseases. The aim of our study was to analyse and compare children's knowledge and skills in hand hygiene before and after school interventions in order to evaluate the effectiveness of our peer education programme.Materials/methodsIn our longitudinal study, short- and long-term changes in the knowledge, hand-washing skills and health behaviour of 224 lower, upper and secondary school students were assessed. Our measurements were performed with a self-administered, anonymous questionnaire and the Semmelweis Scanner.ResultsAs a result of the intervention, the proportion of correct answers increased significantly both in the short term and in the long run compared to the input measurements, but age differences did not disappear for most variables. There is a difference in the process of learning theoretical knowledge and practical skills. Areas not used for handwashing in the paediatric population are different from those described for adults in the literature. There was no significant difference between the mean scores of the right and left hands.ConclusionsThere was a significant positive change in both theory and practice of handwashing. In education, emphasis should also be put on long-term retention of theoretical knowledge in age-specific health promotion programmes within the paediatric population.
Kyrgyz Libraries Community – Co-Operation for Development: New Challenges and New Approaches
Authors: Battalova Sania 
Published: November 2020

“Kyrgyz Libraries Information Consortium”, one of the largest library associations in the country, celebrates its 10th anniversary. The Consortium was established in 2002 and through membership, it comprises more than 400 libraries within Kyrgyzstan, including the National Library, the State Patent and Technical Library, the Library of the Academy of Science, and many other academic and regional libraries. The Consortium’s creation was an answer to the challenges the country faced: lack of information, very low level of technological development, no budget for collection development, lack of cooperation and collaboration between libraries in the country as well as with the international library community.
The history and development of the Consortium, the Consortium mission, its goals, its main initiatives and the strategic directions to be taken are presented in the article. The importance of library development and how libraries in developed countries established strong and effective organizations are reviewed and analyzed here. This paper also presents the challenges and approaches that must be taken for future development of libraries in Kyrgyzstan.
Agricultural and Food E-Resources Usage at the University of the West Indies (UWI) Mona Campus
Authors: Harris Sasekea Yoneka 
Published: November 2020

An analysis of selected agricultural and food e-resources at UWI Mona Campus indicate only a small percentage of students and lecturers are utilizing these.
These statistics are alarming for a number of reasons, namely: (a) the high cost of these e-resources; (b) the value in e-resources as posited by authors; (c) the reality that e-resources are a feature of the Web 2.0 age in which we currently reside; (d) and quality reviewers’ and accreditation board members’ expectations of universities to provide e-resources. If it is that e-resources are so valuable and are a feature of the Web 2.0 era and yet they are being underutilized, this has clear implications for research throughput in respect of such matters as: term papers, lectures and publications in agricultural and food sciences. Additionally, the low usage threatens the viability of continuing the provision of these e-resources at UWI. Using the UWI Mona Campus population this paper seeks to provide an understanding of the reasons for the current usage patterns; the implications for collection management as well as for research throughput; and the ways in which greater usage can be encouraged.
RYAN D. GILES AND STEVEN WAGSCHAL, EDS. Beyond Sight. Engaging the Senses in Iberian Literatures and Cultures, 1200-1700. Toronto: University of Toronto Press, 2018. x + 343 pp.
Authors: Perea-Rodríguez Óscar 
Published: November 2020

Review of Beyond Sight. Engaging the Senses in Iberian Literatures and Cultures, 1200-1700 by RYAN D. GILES AND STEVEN WAGSCHAL, EDS.
An in-vitro medical device material biocompatibility study using primary cell cultures of rat osteoblasts
Authors: Shaama Fiayaz , Wilson Ann , Stoute Valerie 
Published: November 2020

<p class="abstract"><strong>Background:</strong> We questioned if simple chemical methods could be applied as a possible biocompatibility test for biomaterials.</p><p class="abstract"><strong>Methods:</strong> In a qualitative experiment, osteoblasts cells harvested from newly born (3-5) day old sprague-dawley rats were cultivated in growth medium in a controlled environment in the presence of titanium (Ti) (American Elements®), cobalt-chromium (Co-Cr) (Nobilium®), bio-activated rattan wood, orthopaedic bone cement (CEMEX®), implant fixtures (Astra TDC), and resorbable suture material (Poly-Gly-Lac) (VICRYL®). Sample aliquots were withdrawn periodically over 16 days. One and two-dimensional polyacrylamide gel electrophoresis (PAGE) as well as isoelectric focusing (IEF) produced spots that were subjected to enzyme digestion and molecular weight determination. In a follow-up quantitative experiment, the same samples, except for those containing CEMEX and VICRYL, were prepared. The alkaline phosphatase (ALP) activity was monitored continuously using the colorimetric Stanbio® kits. The ALP activities at days 2, 4, 8, 12, and 16, designated as a longitudinal variable, TIME, were analysed, using SPSS V.22, as a mixed ANOVA model with TIME as a repeated measure and the material type as an independent factor.</p><p class="abstract"><strong>Results:</strong> The IEF and second dimension PAGE produced an additional spot for Ti at pH(I) of 5-6. This was identified as IQUB_RAT IQ, a ubiquitin-like domain, molecular weight 2.6 kDa. This method was able to find finite differences in osteoblast activity after initial exposure to a foreign body. Both the ALP activity changes from one day to the next for all materials and the TIME-material type interaction effects were significant (p=0.000).</p><p class="abstract"><strong>Conclusions:</strong> This technique is suitable for use with human cell lines or clones. Experiments like these reduce the need for animal testing. </p>
Floraciones de cianobacterias en Colombia: estado del conocimiento y necesidades de investigación ante el cambio global
Authors: Salomón Samia , Rivera-Rondón Carlos A. , Zapata Ángela María 
Published: November 2020

Las floraciones de cianobacterias pueden causar problemas en la calidad del agua por su rápido crecimiento y abundancia. Además de generar biomasa en exceso, causan cambios físicos, químicos y biológicos en el ecosistema. Asimismo, las cianobacterias producen neurotoxinas, hepatotoxinas y dermatotoxinas, entre otras. Los problemas asociados con las floraciones de cianobacterias han aumentado en las últimas décadas y, en consonancia, se ha incrementado a nivel global el número de investigaciones sobre las floraciones tóxicas y su efecto en los ecosistemas y la salud humana; hoy muchos países cuentan con protocolos para su manejo. Los principales factores del cambio climático global asociados con una mayor presencia y duración de las floraciones de cianobacterias son el incremento de temperatura, la eutrofización, las alteraciones hidrológicas, el aumento en la estabilidad física de la columna de agua y los cambios en las redes tróficas. En Colombia la eutrofización y el aumento en la temperatura del agua son problemas crecientes y, a pesar de ello, no existe un registro al respecto ni normas estatales que permitan reportar los casos, hacer seguimiento e implementar medidas de control y manejo. En esta revisión se presenta el estado actual del conocimiento sobre dichas floraciones en el país y las expectativas ante el cambio climático global.