bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between the accuracy of Montreal Cognitive Assessment and Mini-Mental State Examination in the detection of mild cognitive impairment
Authors: Aminisani Nayyereh , alimi Rasoul , Javadpour Ali , Asghari-Jafarabadi Mohhamad , Jourian Mozhgan , Stephens Chris , Shamshirgaran Morteza 
Published: January 2021

Abstract
Introduction:Ageing can cause major changes in the central nervous system of the body, resulting in cognitive decline and associated disorders. Therefore, there is a growing need for an effective cognitive screening method to enhance the diagnosis of mild cognitive impairments and to prevent occurring dementia and Alzheimer's Disease (AD). Our study aimed to compare the accuracy of MMSE (Mini-Mental State Examination) and MoCA (Montreal Cognitive Assessment) while evaluating the independent and interaction effects of age and educational level on these screening tools in a healthy sample.Method: The data for the current study was based on the registration phase of the study during 2016-2018 in Neyshabour Longitudinal Study on Ageing (NeLSA). Both the MoCA and MMSE tests were used to assess cognitive decline among 3326 participants aged 50-94 years of old. The ROC curve analysis and the predictive values were performed to evaluate the diagnostic accuracy of MMSE to discriminate Mild Cognitive Impairment (MCI) from the cognitively healthy adult basis of MoCA scores as a gold test. A two-way ANCOVA was run to examine the effect of Age and Education level on MoCA and MMSE score, while controlling for a gender effect. Data were analyzed using MedCalc Statistical Software version 13.0.6 (MedCalc Software bvba, Ostend, Belgium; http://www.medcalc.org; 2014). Results: The chi-square test shows that MoCA ((72% and 90%) significantly (p-value<0.001() classified more persons as cognitively impaired than the MMSE (45.1%), respectively; using a cutoff score of 24 on the MMSE, 23 and 26 on the MoCA. The cut-off point of below 25 yielded the highest Youden J index for the MMSE in discrimination between MCI and healthy basis of MOCA<23 with an AUC of 0.9 (95% CI: 0.89-0.91) and MOCA<26 with an AUC of 0.87 (95% CI: 0.86-0.89). A two-way ANCOVA results show that the effect of education variable on the MMSE and MoCA score is more important than the age variable.Discussion: Although the cut-off scores give a clear indication of the sensitivity and specificity, they are unable to monitor the impact of confounders, which increase the risk of incorrect classification. Taken together, these findings demonstrate the use of demographically adjusted MoCA and MMSE scores that could provide clinicians with a more reliable estimation of the severity of cognitive impairment, thus increasing the instrument's clinical usefulness.
Risk Factors of Uterine Contraction After Ureteroscopy in Pregnant Women With Renal Colic
Authors: Li Chunjing , Li Jierong , Zhou Yanfen , Guo Mingjuan , Zhang Shilin , Liu Guoqing 
Published: January 2021

Abstract
Background: Ureteroscopy is widely applied in pregnant women with renal colic, but such patients are easy to experience uterine contraction after ureteroscopy, There are many factors which may result to uterine contraction, this study aims to explore the risk factors of uterine contraction triggered by ureteroscopy in pregnant women with renal colic. Methods: 101 pregnant women were retrospectively analyzed, all patients were hospitalized because of severe renal colic. All patients received ureteroscopy during which double J catheters were inserted into ureters for drainage. Patients received medical treatment individually according to their condition and the uterine contractions were detected by EHG within 12 hours after operation. Patients were classified as group A (uterine contraction, n=46) and group B (no uterine contraction, n=55) according to the presence or absence of continuously regular uterine contraction. Clinical characteristics were collected for further analysis, including history of deliveries, anesthesia methods, application of phloroglucinol or not, surgical time, Oxygen inhalation or not, pain relief or not after surgery, systemic inflammatory response syndrome(SIRS) occurred or not. A binary logistic regression analysis model was established to explore whether such clinical characteristics were relevant to uterine contraction after ureteroscopy. Results: The incidence of continuously regular uterine contraction occurred within 12 hours after ureteroscopy in pregnant women was 45.54%, and the presence of uterine contraction was related to the following factors(P<0.05): history of deliveries(primipara versus multipara)(OR=6.593, 95%CI 2.231-19.490), surgical time(each quarter additional)(OR=2.385, 95%CI 1.342-4.238), application of phloroglucinol(yes versus not)(OR=6.959, 95%CI 1.416-34.194), pain relief after surgery(yes versus not)(OR=6.707, 95%CI 1.978-22.738), SIRS occurred after surgery(yes versus not)(OR=0.099, 95%CI 0.014-0.713). Conclusion: Continuously regular uterine contraction is easy to occur within 12 hours after ureteroscopy in pregnant women. SIRS occurred after surgery is a risk factor for uterine contraction; on the contrary, no history of childbirth, shorter surgical time, application of phloroglucinol, pain relief after surgery are protective factors.
Evaluation of Anticoagulation Outcome among Patients Taking Warfarin: A Single-Center Experience, Northwest Ethiopia
Authors: Liyew Zelalem , tadesse abilo , Bekele Nebiyu , Tsegaye Tewodros 
Published: January 2021

Abstract
BackgroundWarfarin is a widely used oral anticoagulant in clinical practice. It is used to prevent arterial emboli in patients with atrial fibrillation, or prevent and treat venous thromboembolism. The efficacy and safety of warfarin depends on maintaining the INR within the therapeutic range. The proportion of time spent in the therapeutic INR range (TTR) is used to evaluate quality of anticoagulation control.MethodsA hospital-based cross sectional study was conducted between November 1, 2019 and October 31, 2020 at Cardiac and Hematology Clinic, University of Gondar hospital. A consecutive sampling method was used to recruit 338 study subjects. Proportion of time spent in the therapeutic range (TTR) was calculated using the Rosendaal’s linear interpolation method. TTR ≥65% was described as ‘optimal’ International Normalized Ratio (INR) control. The Data were entered into EPI Info version 4.4.1 and transported to SPSS version 20 for analysis. Logistic regression analysis was used to identify associated factors with optimal anticoagulation outcome (TTR ≥65%). P-values <0.05 were used to declare significant association.ResultA total of 338 study subjects were included in the study. The mean age of patients was 49 years. The majority of study participants attended formal education (79%) and were urban dwellers (57%). Atrial fibrillation was the commonest indication for warfarin therapy. One-third (33%) of study subjects achieved the desired INRs (INR=2.0-3.0), while about one-tenth (13%) of patients attained optimal INR control (TTR≥65%). There were no significant association of socio-demographic characteristics including age, gender, educational level and monthly income with optimal INR control (TTR ≥65%). Likewise, clinical characteristics including dose of warfarin, warfarin adherence, frequency of INR determination, other concomitant drug intake, co-existing comorbidities, consumption of green leafy vegetables and alcohol intake didn’t show significant association with optimal INR control (TTR≥65%).ConclusionInstitution-based validated protocol might be required to overcome the poor TTR level. ‘Anticoagulation (INR) clinic’ would be required to ‘scale-up’ INR control.
Association of HLA-DR&nbsp;Alleles With Pulmonary Cystic Fibrosis
Authors: asef alireza , Ghaffaripour Hossein Ali , Jamaati hamidreza , Varahram Mohammad , Adcock Ian , Mortaz Esmaeil 
Published: January 2021

Abstract
Background: Cystic fibrosis (CF) is the most common lethal autosomal recessive disease in white Caucasians. It affects many organs including the lung, pancreas, and liver. Whilst CF is a monogenic disease, several studies revealed a complex relationship between genotype and clinical phenotype of diseases. Objective of study: We examined the expression of HLA class II alleles among Iranian CF patients in relation to disease-related bacterial infection. Materials and methods: This study was conducted on 50 CF patients (27 males, 23 females aged 15.5±6.5 years) hospitalized in the Masih Daneshvari hospital in Tehran, Iran and 50 healthy age- and gender-matched control subjects. 5ml whole blood was harvested and after isolation of genomic DNA, HLA-DRB1 subtypes were determined by Single Specific Primer Polymerase Chain Reaction (SSP-PCR) methods. Results: HLA-DRB1*10 was less frequent than HLA-DRB1*04 and HLA-DRB1*11 but none reached significance. 16 CF patients with high serum IgE levels (430.25 ± 219.7 IU/ml) and 27 CF patients positive for Pseudomonas aeruginosa colonization were most closely associated with the HLA-DRB1*04 allele. 31 CF patients had candida Albicans colonization which was most closely associated with HLA-DRB1*11. 3 CF patients had allergic bronchopulmonary aspergillosis (ABPA) and two were diabetic. Discussion: The DR4 and DR11 serotypes that recognize the HLA-DRB1*04 and HLA-DRB1*11 gene products respectively, are not significantly enriched in the Iranian CF population. Further research should be conducted on DR4 and DR11 in CF patients to understand their possible role in infection and IgE expression.Trial registration: The study was approved by Ethical committee of Masih Daneshvari Hospital IR.SBMU.NRITLD.1395.234
Development of Species/Genus specific Primers for Identification of Three Trichoderma Species and for Detection of Trichoderma Genus
Authors: Zhou You , Wang Jun , Yang Laying , Guo Lijia , He Shuting , Zhou Wei , Huang Junsheng 
Published: January 2021

Abstract
Trichoderma is a widely used bio-control agent, and has excellent ability to antagonize plant pathogens and promoting plant growth. It has been successfully used to control various plant diseases. The premise of using Trichoderma is accurate identification of it. In this study, four sets of species/genus-specific primers were designed based on the translation elongation factor 1-alpha (tef1) gene and internal transcribed spacer (ITS) region, in order to identify Trichoderma harzianum, T. koningiopsis, and T.virens, and detect the genus of Trichoderma. Here, the rapid, simple, and reliable PCR methods were development using the species-specific primers EHarF2/EHarR2, EKoisF/EKoisR, and EVireF/EVireR to produce 253 bp (tef1 gene), 255 bp (tef1 gene), and 263 bp (tef1 gene) DNA bands to identify T. harzianum, T. koningiopsis, and T. virens, respectively. The genus-specific primers ITricF/ITricR produces a single DNA band in the range of 103–113 bp (ITS region) to distinguish Trichoderma from other genera fungi, and the size of the band is related to the species of Trichoderma. In addition, ITricF/ITricR could use for real-time PCR amplification for detection the quantity of Trichoderma spp..
Sliding Mode Variable Impedance Control for 4RRR Redundantly Actuated Parallel Robot
Authors: Fan Ya-Nan , He Guang-Ping , Liang Xu , Su Ting-Ting , Zhang Jie 
Published: January 2021

Abstract
The workspace of parallel robot is limited, and the distribution characteristics of kinematics and force maneuverability are complex in the workspace. In addition, there are often operational singularities. The redundant actuation technology can not only overcome singularity problem of force maneuverability of parallel mechanism, but also eliminate the clearance of the mechanism, dynamically adjust the operating stiffness, realize the optimized operation of energy consumption, etc. In this paper, with the goal of realizing dexterous dynamic output control, the variable impedance control technology of redundantly actuated parallel robot based on operation space is studied. Compared with the traditional invariable impedance control, the variable impedance control can adapt to the change of unknown environment by time-varying controlling parameters, which provides the possibility to realize the polishing of complex curved surfaces and thin-walled parts, assembly task and improves the performance of the system and the machining quality of the parts. In order to avoid the influence of unmodeled errors and external interferences on the system, based on the sliding mode control (SMC) strategy, the variable impedance control (VIC) in the operating space of 4RRR redundantly actuated parallel robot (4RAPR) is proposed. The robust stability of the closed-loop system is analyzed and verified by Matlab programming simulation.
Raman spectroscopic quantification of tetrahedral boron in synthetic aluminum-rich tourmaline
Authors: Kutzschbach Martin , Wunder Bernd , Wannhoff Iris , Wilke Franziska D.H. , Couffignal Frédéric , Rocholl Alexander 
Published: January 2021

Abstract
The Raman spectra of five [4]B-bearing tourmalines of different composition synthesized at 700 °C/4.0 GPa (including first-time synthesis of Na-Li-[4]B-tourmaline, Ca-Li-[4]B-tourmaline, and Ca-bearing ☐-[4]B-tourmaline) reveal a strong correlation between the tetrahedral boron content and the summed relative intensity of all OH-stretching bands between 3300–3430 cm–1. The band shift to low wavenumbers is explained by strong O3-H···O5 hydrogen bridge bonding. Applying the regression equation to natural [4]B-bearing tourmaline from the Koralpe (Austria) reproduces the EMPA-derived value perfectly [EMPA: 0.67(12) [4]B pfu vs. Raman: 0.66(13) [4]B pfu]. This demonstrates that Raman spectroscopy provides a fast and easy-to-use tool for the quantification of tetrahedral boron in tourma-line. The knowledge of the amount of tetrahedral boron in tourmaline has important implications for the better understanding and modeling of B-isotope fractionation between tourmaline and fluid/melt, widely used as a tracer of mass transfer processes.
Histone Demethylase KDM4A Inhibition Represses Neuroinflammation and Improves Functional Recovery in Ischemic Stroke
Authors: Liu Yanfei , Zhao Liang , Zhang Jianzhong , Lv Liquan , Han Kaiwei , Huang Chengguang , Xu Zheng 
Published: January 2021

Background:
Epigenetic regulation concerning histone lysine methylation and demethylation play a
crucial role in cerebral ischemic injury. Dysregulation of histone methylation modifiers has been identified in
cerebral ischemia. However, the function and the underlying mechanisms of histone demethylase KDM4A on
neuroinflammation and functional recovery in ischemic stroke remains unclear.

Methods:
In the present study, the rat model of transient middle cerebral artery occlusion (MCAO) was established,
and the expression level of KDM4A was assessed in brain tissues. KDM4A inhibition was carried out
by intrathecal injection with Lv-shKDM4A, and then pro-inflammatory cytokines and neurological functional
tests were assessed.

Results:
We demonstrated that rats subjected to MCAO showed a markedly increased expression of KDM4A,
pro-inflammatory cytokines IL-1β and TNF-α, and vascular endothelial growth factor (VEGF), whereas KDM4A
inhibition repressed the expression of IL-1β, TNF-α and VEGF both in MCAO and oxygen-glucose deprivation
(OGD) models. Furthermore, KDM4A inhibition showed a marked improvement in spatial learning and
sensorimotor function, as suggested by mNSS and foot-fault test, respectively. Mechanistically, KDM4A inhibition
repressed NF-κB signaling activation in microglia as indicated by decreased expression and nuclear translocation
of p65 in vitro and in vivo. The effects of KDM4A overexpression on exacerbating neuroinflammation
was inhibited by additional treatment of NF-κB inhibitor (JSH-23).

Conclusion::
The current results demonstrated KDM4A inhibition improves functional recovery in ischemic
stroke by repressing NF-κB activation and subsequent neuroinflammation.
Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergistic Therapy
Authors: Ding Qiongjie , Liu Yiwei , Shi Chuncheng , Xiao Jifei , Dai Wei , Liu Dong , Chen Haoyuan , Li Baohong , Liu Jianqiang 
Published: January 2021

Background:
Metal-organic frameworks (MOFs) possess adjustable aperture, high load
capacities, tailorable structures, and excellent biocompatibilities for their use as drug delivery carries
in cancer therapy. Until now, Zr-MOFs, in particular, combine optimal stability towards hydrolysis
and post synthetic modification with low toxicity, and are widely studied for their excellentbiological
performance.

Introduction:
This review comprises the exploration of Zr-MOFs as drug delivery devices (DDSs)
with a focus on various new methods, including chemotherapy (CT), photodynamic therapy (PDT),
photothermal therapy (PTT), sonodynamic therapy (SDT), radiotherapy, immunotherapy, gene therapy
and related combined therapies, which all generate reactive oxygen species (ROS) to achieve high
efficiency of tumor therapy.

Conclusion:
We described and summarized these pertinent examples of the therapeutic mechanisms
and highlighted the antitumor effects of their biological application both in vitro and in vivo. The perspectives
on their future applications and the analogous challenge of the Zr-MOFs materials are given.
Systematic Analysis and Review of Magnetic Resonance Imaging (MRI) Reconstruction Techniques
Authors: Kumar Penta Anil , Gunasundari Ramalingam , Aarthi Ramalingam 
Published: January 2021

Background:
Magnetic Resonance Imaging (MRI) plays an important role in the field
of medical diagnostic imaging as it poses non-invasive acquisition and high soft-tissue contrast.
However, a huge time is needed for the MRI scanning process that results in motion artifacts, degrades
image quality, misinterprets the data, and may cause discomfort to the patient. Thus, the
main goal of MRI research is to accelerate data acquisition processing without affecting the quality
of the image.

Introduction:
This paper presents a survey based on distinct conventional MRI reconstruction
methodologies. In addition, a novel MRI reconstruction strategy is proposed based on weighted
Compressive Sensing (CS), Penalty-aided minimization function, and Meta-heuristic optimization
technique.

Methods:
An illustrative analysis is done concerning adapted methods, datasets used, execution tools, performance
measures, and values of evaluation metrics. Moreover, the issues of existing methods and the research gaps considering
conventional MRI reconstruction schemes are elaborated to obtain improved contribution for devising significant MRI
reconstruction techniques.

Results:
The proposed method will reduce conventional aliasing artifact problems, may attain lower
Mean Square Error (MSE), higher Peak Signal-to-Noise Ratio (PSNR), and Structural SIMilarity
(SSIM) index.

Conclusion:
The issues of existing methods and the research gaps considering conventional MRI
reconstruction schemes are elaborated to devising an improved significant MRI reconstruction technique.
THE EFFECT OF TEAM WORK, LEADERSHIP STYLE, AND ORGANIZATIONAL CULTURE ON NURSE PERFORMANCE WITH ORGANIZATIONAL COMMITMENTS AS MEDIATION VARIABLES IN HOSPITAL TYPE B IN JAKARTA
Authors: Wahyuningsih Sri Ari , Thoyib Armanu , - Rofiaty , Sabil Ananda 
Published: January 2021

ABSTRACT This study aims to analyze the influence of team work, leadership style and organizational culture on nurse performance with organizational commitment as a mediating variable. The research unit is nurses at Type B hospitals in Jakarta. The population is 1362 nurses. Methods of collecting data using surveys. The research instrument used a questionnaire. Questionnaires were distributed to 523 respondents. Data analysis method uses Structural Equation Modeling-Partial Least Square SEM-PLS). The results of the study prove that teamwork has a positive effect on nurse performance. Teamwork does not affect organizational commitment. Organizational culture has a positive effect on nurse performance. Organizational culture has a positive effect on organizational commitment. Leadership style does not affect nurse performance. Leadership style does not affect organizational commitment. Organizational commitment has a positive effect on nurse performance. Organizational commitment cannot play a role in mediating the influence of teamwork on nurse performance. Organizational commitment can play a role in mediating the influence of organizational culture on nurse performance. Organizational commitment cannot play a role in mediating the influence of leadership style on nurse performance.Â Keywords: Teamwork, Organizational Culture, Leadership Style, Organizational Commitment, Nurse Performance.
FACTORS AFFECTING VOLUNTARY DISCLOSURE WITH CORPORATE GOVERNANCE AS MODERATING VARIABLES
Authors: Widayawati Eny , Dzulkirom Moch , Darmawan Ari 
Published: January 2021

ABSTRACTPurpose â€” The purpose of this research is to analyze and prove the influence of independent variables that are proxied by profitability, liquidity, firm size on voluntary disclosure, and moderated by corporate governance variables.Design/methodology/approach â€” The object of the research is the companies listed on the IDX from 2012 through 2016. This research uses a purposive sampling method involving 45 annual company reports and uses multiple regression and MRA (Moderated Regression Analysis) as a data analysis tool.Findings â€” The results of this research indicate that there is a significant positive effect between liquidity, firm size on voluntary disclosure, there is a significant negative effect between profitability and voluntary disclosure, and corporate governance moderates the relationship between profitability, liquidity, firm size, and voluntary disclosure.Practical Implications â€”Â Companies with high liquidity supported by good corporate governance will reduce voluntary disclosures due to the existence of independent commissioners whose positions are still less influential with the board of commissioners and board of directors, in the other hand, companies with low profitability supported by good corporate governance encourage managers to disclose company information more broadly to convince all stakeholders concerned.Originality/value â€” Keywords Profitability, Liquidity, Company size, Corporate governance, Voluntary disclosure.Paper Type Research Paper (secondary data)