bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher Education Reconsidered: Beyond the Pandemic and Possibilities for New Knowledge Architectures
Authors: Osman Ruksana 
Published: November 2020

ABSTRACT
The COVID-19 pandemic is reshaping all dimensions of life as we know it, including higher education. The pandemic has forced the global academy to question what it means to be a university, to reconsider its role in society and its relationship with other social actors. Concomitantly, it has provided the academy with a moment to pause, to reflect, and to propose new imaginaries, against a rapidly changing technological landscape, in a world where new challenges emerge daily, and which, like the coronavirus, force change into unchartered waters. This article proposes shifts in six areas which, coupled with strong, empathetic visionary leadership, advance new considerations for the knowledge project of the academy to prosper.
Prácticas de equidad y calidad en la Universidad Veracruzana, Campus Poza Rica
Authors: Villalobos López Marilú , Barrales Villegas Adoración , Dajer Torres Regina 
Published: November 2020

A pesar de los avances que la humanidad ha tenido en diferentes esferas, todavía no se ha logrado garantizar de manera universal los derechos humanos o brindar calidad de vida a toda la humanidad. Un aspecto que se vuelve clave es la equidad y, cuando la ausencia de equidad se presenta en una institución educativa, se ve afectada también su calidad. Por tal motivo, el presente escrito muestra resultados obtenidos de una investigación sobre Equidad y Calidad como parte del Proyecto Europeo ORACLE 2019 (Observatorio Regional de Calidad de la Equidad de la Educación Superior en Latinoamérica), realizada en la Universidad Veracruzana en su Región Poza Rica – Tuxpan. Para este informe, se presentan específicamente los resultados obtenidos en la Facultad de Arquitectura. Dicha investigación pretendía conocer las prácticas de equidad y calidad que se observan en dicha institución desde la perspectiva del personal docente y de los estudiantes.
La prescripción de las infracciones en el Derecho Administrativo Sancionador peruano
Authors: Ayvar Ayvar Ricardo , Borda Gianella Waldo 
Published: November 2020

La prescripción es una figura jurídica de especial relevancia para el Derecho Administrativo Sancionador debido a que permite limitar el ius puniendi del Estado frente al administrado, quien precisa de seguridad jurídica para desarrollar sus actividades.Aunque la norma general aplicable es la Ley del Procedimiento Administrativo General, también es preciso evaluar la incidencia de las normas específicas respecto de la prescripción.El autor inicia este análisis definiendo la naturaleza jurídica y tipología de la prescripción para, posteriormente, emitir un juicio crítico respecto de su tratamiento según las normas generales y específicas.Finalmente, expone la aplicabilidad de sus circunstancias especiales: interrupción y suspensión.
Tindak Pidana Perdagangan Satwa Liar Dilindungi yang Berimplikasi Tindak Pidana Pencucian Uang
Authors: Sutra Ferna Lukmia 
Published: November 2020

Satwa liar dilindungi merupakan sumber daya alam hayati yang perlu dijaga. Namun potensi sumber daya alam Indonesia mulai terganggu karena praktek perdagangan satwa liar dilindungi pada berbagai macam modus. Peningkatan kejahatan tersebut terjadi karena faktor ekonomi, lemahnya penegakkan hukum, permintaan pasar yang tinggi, dan pelaku memiliki jaringan nasional dan internasional. Regulasi terkait perdagangan satwa liar dilindungi yakni Undang-Undang Konservasi Sumber Daya alam Hayati dan Ekosistemnya nampakanya belum mengakomodasi subjek pelaku korporasi dan efek jera. Lembaga penegak hukum perlu mengggunakan berbagai peraturan yang ada salah satunya menggunakan instrumen pencucian uang. Penelitian hukum ini membahas perdagangan satwa liar dilindungi sebagai tindak pidana asal dalam tindak pidana pencucian uang dan pertanggungjawaban pelaku perdagangan satwa liar dilindungi berimplikasi tindak pidana pencucian uang dengan metode pendekatan perundang-undangan dan pendekatan konseptual. Berdasarkan pembahasan dapat diketahui bahwa beberapa praktek perdagangan satwa dilindungi sulit terdeteksi, salah satunya karena hasil tindak pidana telah masuk pada legal market. Hal ini menunjukkan pentingnya instrumen hukum untuk menjerat subjek pelaku yang memproses pencucian uang. Hasil dari penelitian dapat disimpulkan bahwa Undang-Undang Konservasi Sumber Daya alam Hayati dan Ekosistemnya dapat memenuhi syarat sebagai tindak pidana asal di dalam tindak pidana pencucian uang. Pertanggungjawaban pelaku perdagangan satwa liar dilindungi dapat berimplikasi pada tindak pidana pencucian uang, sehingga Undang-Undang Pencegahan dan Pemberantasan Tindak Pidana Pencucian Uang dapat menjadi instrumen hukum untuk memberantas kejahatan ini.
Penerapan Konsep A.B.L.E. Pada Ruang Terapi Anak Berkebutuhan Khusus Cerebral Palsy
Authors: Handoyo Andreas Dwiputro , Liritantri Widyanesti , Pramesi Mutiara Dhya Ulhaq , Meirissa Allicia Sandra 
Published: November 2020

<p class="Abstract"><em>Cerebral Palsy is a condition characterized by poor muscle control, stiffness, paralysis, to other nerve disorders. These children are at the highest level of priority among children with special needs. Helping children with Cerebral Palsy can be realized through the design of a special therapy centre for children with Cerebral Palsy. The design of this therapy centre will be specified in the design concept of the play therapy room because in this case, the playground works as well as therapeutic method for children. This study was conducted using qualitative descriptive analytical methods in Risantya facility which applies play as a therapeutic approach. The observation focused on the activities of the children in the playground. It was found that four factors play an important role in the therapy area. A.B.L.E. has meaning, namely A for Attractive Colours, B for Bump, Bruise, and Pain-Free, L for Low Physical Effort, and E for Engaged positively with movement. The concept is described to therapy centre, especially in the play therapy room, where this concept aims to provide a sense of ease, safety, and comfort to children when doing activities.</em></p>
Development and Validation of an Immune Microenvironment Based Prognostic Signature and Signal Pathways in Prostate Cancer
Authors: Zhao Qi , Cheng Yingying , Ren Yujie , Li Xianfa , Xiong Ying 
Published: November 2020

Abstract
BackgroundThe study of the PCa immune microenvironment has brought new opportunities for the clinical diagnosis and treatment of PCa, but the current study has failed to obtain satisfactory results. We aim to develop a generalized, individualized immune prognostic signature that can improve the survival rate of patients.MethodsWe collected a total of 591 sample data from the TCGA and GEO cohorts, and evaluated the abundance and distribution of immune cell members in the mixed cell population in the gene expression matrix by CIBERSORT, ESTIMATE, ssGSEA, and other methods. Calculate the TMB value of the mutant gene to evaluate the reliability of PCa for immunotherapy. Besides, the genes related to the immune microenvironment and mutation load of PCa are obtained, and the target genes are obtained by the intersection with the immune-related genes in the ImmPort database. And perform pan-cancer analysis of the target gene to evaluate the immunological commonality and biological pathways in a variety of cancers. Finally, a Western blot experiment was used to explore the mechanism of the target gene in PCa immune microenvironment.ResultsWe found that M0, M2, and Mast cell sresting differed significantly between prostate cancer and normal tissue and that patients with low plasma cell abundance were more likely to develop lymph node metastasis. LTF, as a core gene, is closely related to changes in the immune microenvironment of PCa, and its low expression in tumors promotes primary immune deficiency, cancer development, and enrichment in the JAK/STAT signaling pathway. Cell experiments found that LTF overexpression reduces tumor-derived GM-CSF secretion by inhibiting JAK/STAT pathway, achieving the purpose of regulating tumor immune microenvironment and inhibiting PCa cell proliferation and migration.ConclusionsThe proposed clinical-immune signature and core gene is the most promising biomarkers for improving the overall survival rate of PCa. It has been verified that overexpression of LTF reduces the secretion of tumor-derived GM-CSF by inhibiting the JAK/STAT pathway.
Intravenous fracture of a peripheral&nbsp;cannula at the dorsum of the hand;&nbsp;in a patient who used&nbsp;walking aids after surgery
Authors: Karunathilaka Chandana , Pinto Narendra , V.P. Wijesundara , N.N.N. Madushanka 
Published: November 2020

Abstract
In orthopedic patients peripheral intra venous (IV) cannulation is a common procedure for various clinical purposes. After the surgery most of the patient uses walking aids (walking frame, crutches) for mobilization. The dorsum of the hand or wrist is one of the most common place for the peripheral IV cannulation. When patients holding weight bearing devices, there is a potential of bending the catheter part of the cannula. Repeated bending can result in fatigue fracture of the cannula. To avoid these, it is advisable to place the peripheral venous cannulas at places away from wrist joint which will prevent the catheter bending and fracture of it. This is an very important point to be consider when placing cannulas in orthopedic surgical patients.
Biomaterials and oxygen join forces to shape the immune response and boost SARS-CoV-2 vaccines
Authors: Colombani Thibault , Eggermont Loek , Rogers Zachary , McKay Lindsay , Avena Laura , Johnson Rebecca , Storm Nadia , Griffiths Anthony , Bencherif Sidi 
Published: November 2020

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an unprecedented global health crisis, resulting in a critical need for effective vaccines that generate protective antibodies. Protein subunit vaccines represent a promising approach but often lack the immunogenicity required for strong immune stimulation. To overcome this challenge, we first demonstrate that advanced biomaterials boost effectiveness of SARS-CoV-2 protein subunit vaccines. Additionally, we report that oxygen is a powerful immunological co-adjuvant, a game-changer in the field for unlocking the full potential of vaccines. Mice immunized with oxygen-generating cryogel vaccines exhibited a robust and balanced Th1 and Th2 immune response, leading to sustained and high titer production of neutralizing antibodies against SARS-CoV-2. Our data indicate that this platform is a revolutionary technology with the potential to reinforce any vaccine.
Cuttlebone Fillers for Topical Hemorrhage and Wound Healing: In Vitro Insights and a Suppository Model
Authors: Palaveniene Alisa 
Published: November 2020

Abstract
BackgroundWhile the treatment of numerous anorectal disorders remains challenging, this paper aims to add an impact and suggests a product prototype with marine-derived non-toxic cuttlebone fillers for clinical use. MethodsElemental composition, hemostatic and antibacterial potential of cuttlebone fillers were tested in vitro while comparing with a number of clotting powders. Witepsol-based suppositories with lidocaine hydrochloride and cuttlebone fillers were further developed. ResultsCuttlebone microparticles (CB-1) and modified alkali-treated cuttlebone microparticles (CB-2) were analyzed in terms of hemostatic efficiency and as fillers for rectal suppositories for the first time (Fig. 1). Bioinorganic elements of cuttlebone, such as iron, zinc, copper, calcium and magnesium were found to be supportive for wound healing. Modified, chitosan-enriched cuttlebone filler showed decrease in clotting time by 20%. Cuttlebone fillers demonstrated no antimicrobial activity against S. aureus and P. aeruginosa. Suppositories with cuttlebone fillers have demonstrated favorable characteristics, such as melting point in a 36.0–37.0 °C temperature range, dissolution time no longer than 30 min and gradual release of the anesthetic drug. ConclusionBased on the primal, though essential to conduct in vitro test results, application of cuttlebone fillers could open a new page in the development of successful naturally-based hemostatic and wound healing products.
Leiomyosarcoma with Isolated Metastasis to the Extraocular Muscle: A Case Report involving Whole-Exome Sequencing
Authors: Lee Kyoung Yul , Yoo Yung Ju 
Published: November 2020

Abstract
Background: Whole-genome sequencing analysis of leiomyosarcoma of the orbit, a rare condition, has seldom been reported. Here, we describe a case of metastatic orbital leiomyosarcoma, which was confirmed before the diagnosis of the primary tumor.Case presentation: A 71-year-old man presented with total ptosis of the right eyelid. Limitations of supraduction and infraduction of the right eye were present, resulting in left hypotropia at the primary gaze. Enhanced magnetic resonance imaging of the right orbit revealed an extraconal, peripherally enhancing mass arising from the superior rectus muscle. The diagnosis of leiomyosarcoma was confirmed by histopathologic examination. Next-generation sequencing revealed the absence of mutations such as TP53, RB1, and ATRX, which were previously detected in leiomyosarcoma. Conclusions: This case indicates that in patients with ocular movement limitation and ptosis, an orbital mass on the external ocular muscle should be considered, along with the possibility of metastatic lesions. Systemic examination and excisional biopsy should be performed.
Evaluating the implementation of a pragmatic person-centered communication tool in the nursing home via the RE-AIM framework.
Authors: Abbott Katherine , Heppner Alexandra , Hicks Nytasia , Hermesch Abigail , VanHaitsma Kimberly 
Published: November 2020

Abstract
Background: Person-centered care (PCC) is a philosophy that recognizes “knowing the person” and honoring individual preferences. The purpose of this study was to evaluate the implementation of a novel PCC communication tool in nursing homes (NH). The tool is based on an assessment of NH resident likes and dislikes via the Preferences for Everyday Living Inventory (PELI), which is an evidenced-based, validated instrument used to enhance the delivery of PCC. The Preferences for Activity and Leisure (PAL) Card was developed to communicate residents’ preferences for leisure and activities across care team members. Methods: Providers were recruited to utilize the recreation and leisure items from the PELI to assess resident important preferences and create PAL Cards for 15-20 residents. Providers collected data aligned with the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, Maintenance). Results: Reach and Adoption: A total of n=43 providers registered and n=26 (60%) providers completed the project. Ownership of participating providers included 54% not for profit, 46% for profit, and 8% government owned with an average star rating of 3.7 (SD 1.1) and a range of 1-5. Effectiveness and Implementation: Participants attempted n=424 PAL Cards and completed n=406. The average acceptability of the intervention measure (AIM) was 4.7 (SD 0.4), intervention appropriateness measure (IAM) was 4.5 (SD 0.5), and feasibility of intervention measure (FIM) was 4.6 (SD 0.5). Maintenance: Providers were able to complete 82% of PAL Card placement over the course of 5 months with few cards going missing (<2%). Conclusion: The majority of providers were successful in implementing PAL Cards for residents and reported the intervention as highly acceptable, appropriate, and feasible. The pragmatic PAL Card intervention can assist nursing home providers in meeting PCC regulations and contribute to building relationships between residents, family, and staff.
Emergence of an Adaptive Movement from a Subjective Inference about Resource Distribution
Authors: Sakiyama Tomoko 
Published: November 2020

Abstract
Background: In animal foraging, the optimal search strategy in an unknown environment varies according to the context. When food is distributed sparsely and randomly, super-diffusive walks outperform normal-diffusive walks. However, super-diffusive walks are no longer advantageous when random walkers forage in a resource-rich environment. It is not currently clear whether a relationship exists between an agent’s use of local information to make subjective inferences about global food distribution and an optimal random walk strategy. Methods: Therefore, I investigated how flexible exploration is achieved if an agent alters its directional rule based on local resource distribution. In the proposed model, the agent, a Brownian-like walker, estimates global resource distribution using local resource patterns and makes a decision by altering its rules. Results: I showed that the agent behaved like a non-Brownian walker and the model adaptively switched between diffusive properties depending on the resource density. This led to a more effective resource-searching performance compared with that of a simple random-walk model. Conclusion: These results demonstrate a process of optimal searching dependent on context.
Whole-Genome Resequencing using Next-Generation and Nanopore Sequencing for Molecular Characterization of T-DNA Integration in Transgenic Poplar 741
Authors: Chen Xinghao , Dong Yan , Huang Yali , Fan Jianmin , Yang Minsheng , Zhang Jun 
Published: November 2020

Abstract
BackgroundWith the rapid development of transgenic technology, transgenic plants have been planted all over the world, and transgenic forest trees have also been commercialized. At the same time, the potential threat of transgenic plants to human health and the natural environment has aroused widespread concern. Therefore, safety assessments before field release and commercial planting of transgenic plants are necessary. By determining the copy number and integration sites of T-DNA in transgenic plants, the safety of transgenic plants at the genomic level can be assessed.ResultsIn this study, we performed genome resequencing of Pb29, a transgenic high-resistance poplar 741 line that has been commercialized, using next-generation and Nanopore sequencing. The results revealed that there are two T-DNA insertion sites, located at 9,283,905–9,283,937 bp on chromosome 3 (Chr03) and 10,868,777–10,868,803 bp on Chr10. The accuracy of the T-DNA insertion locations and directions was verified using polymerase chain reaction amplification. Through sequence alignment, different degrees of base deletions were detected on the T-DNA left and right border sequences, and in the flanking sequences of the insertion sites. An unknown fragment was inserted between the Chr03 insertion site and the right flanking sequence, but the Pb29 genome did not undergo chromosomal rearrangement. It is worth noting that we did not detect the API gene in the Pb29 genome, indicating that Pb29 is a transgenic line containing only the BtCry1AC gene. On Chr03, the insertion of T-DNA disrupted a gene encoding TAF12 protein, but the transcriptional abundance of this gene did not change significantly in the leaves of Pb29. Additionally, except for the gene located closest to the T-DNA integration site, the expression levels of four other neighboring genes did not change significantly in the leaves of Pb29. ConclusionsThis study provides important molecular information for safety assessments and management of transgenic poplar 741. Our findings also provide a theoretical basis for safety assessments of other transgenic poplar.
Haematological findings in 158 dairy cows with toxic mastitis with a focus on the leukogram
Authors: Braun Ueli , Gerspach Christian , Riond Barbara , Oschlies Carina , Corti Sabrina , Bleul Ulrich 
Published: November 2020

Abstract
Background: Acute toxic mastitis is characterised by typical clinical findings and changes in the leukogram. The goal of our study was to compare the leukogram of 158 cows with toxic mastitis and 168 clinically healthy cows. The cows were examined clinically and underwent haematological and biochemical examination of blood and bacteriological culture of milk samples. Results: All cows with toxic mastitis were ill and had a poor appetite or anorexia, and 34 cows (21.5%) were recumbent. A single quarter was affected in 119 cows (75.3%), two quarters in 37 cows (23.4%) and three quarters in two cows (1.3%). Bacteriological culture showed gram-negative pathogens in 100 cows (63.3%), gram-positive in 15 (9.5%) and yeast in 4 (2.5%). The median total leukocyte count of ill cows was 4,300 cells/µl, which was significantly lower than 8,000 cells/µl in controls. With the exception of band neutrophils and metamyelocytes, the counts of all components of the leukogram were lower in ill cows compared with controls. Significantly more cows with toxic mastitis had leukopenia (60.1 vs. 4.1%) or leukocytosis (10.1 vs. 3.0%) than controls. Ill cows had significantly lower segmented neutrophil counts than controls (860 vs. 2,598 cells/µl), and 69.5 and 17.3%, respectively, had counts below the reference interval. Ill cows had increased band (77.3%) and metamyelocyte (25.0%) counts compared with control cows (0.6 and 0%, respectively). In ill cows, eosinopenia occurred in 66.4% (controls, 1.8%), monocytopenia in 40.6% (controls, 4.2%) and lymphopenia in 60.2% (controls, 1.8%). Twenty-one ill cows (16.4%) had a regenerative and 57 (44.5%) had a degenerative left shift. The median neutrophil-to-lymphocyte ratio was 0.97 in ill cows and 0.63 in controls. Toxic changes in neutrophils including cytoplasmic basophilia and vacuolisation were seen in 101 (91.8%) of 110 blood smears of ill cows.Conclusions: Acute toxic mastitis results in severe changes in the leukogram particularly leukopenia, lymphopenia and degenerative left shift. The leukogram has significant diagnostic value and may aid in the modification of treatment when needed.
Impact of Hospitalist Care Model on Patient Outcomes in Acute Medical Unit
Authors: Kim Hyun Jeong , Kim Jinhyun , Ohn Jung Hun , Kim Nak-Hyun 
Published: November 2020

Abstract
BACKGROUND: The present study aimed to assess a newly introduced, hospitalist-run, acute medical unit (AMU) model in Korea. The AMU in our institution started in October 2015. Four hospitalists managed patients with acute medical needs that were admitted through the emergency department (ED). STUDY DESIGN: We conducted a retrospective cohort study of all medical inpatients admitted through the ED from June 1, 2016 to May 31, 2017, at a tertiary care hospital. We evaluated 6391 patients whether the hospitalist care in the AMU improved patient outcomes compared to standard non-hospitalist care. METHODS: We created multivariate analysis models to compare the clinical outcomes of patients cared for by hospitalists with the outcomes of patients cared for by non-hospitalists. RESULTS: In the adjusted models, compared to the non-hospitalist group, the AMU hospitalist group had a lower in-hospital mortality (OR: 0.46, P <0.001), a lower intensive care unit (ICU) admission rate (OR: 0.39, P <0 .001), a shorter hospital length of stay (coefficient: -1.349, SE: 0.217; P <0.001), and a shorter ED waiting time (coefficient: -3.021, SE: 0.256; P <0.001). There were no significant differences in the 10-day or 30-day re-admission rates (P = 0.493, P = 0.201; respectively). CONCLUSIONS: The AMU hospitalist care model was associated with reductions in in-hospital mortality, ICU admission rate, length of hospital stay, and ED waiting time. These findings suggested that this AMU hospitalist care model might be adaptable to other healthcare systems to improve care for patients with acute medical needs.