bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently
Authors: Gadi Ihsan , Fatima Sameen , Elwakiel Ahmed , Nazir Sumra , Mohanad Al-Dabet Moh’d , Rana Rajiv , Bock Fabian , Manoharan Jayakumar , Gupta Dheerendra , Biemann Ronald , Nieswandt Bernhard , Braun-Dullaeus Ruediger , Besler Christian , Scholz Markus , Geffers Robert , Griffin John H. , Esmon Charles T. , Kohli Shrey , Isermann Berend , Shahzad Khurrum 
Published: December 2020

Rationale:
While thrombin is the key protease in thrombus formation, other coagulation proteases, such as fXa (factor Xa) or aPC (activated protein C), independently modulate intracellular signaling via partially distinct receptors.

Objectives:
To study the differential effects of fXa or fIIa (factor IIa) inhibition on gene expression and inflammation in myocardial ischemia-reperfusion injury.

Methods and Results:

Mice were treated with a direct fIIa inhibitor (fIIai) or direct fXa inhibitor (fXai) at doses that induced comparable anticoagulant effects ex vivo and in vivo (tail-bleeding assay and FeCl
3
-induced thrombosis). Myocardial ischemia-reperfusion injury was induced via left anterior descending ligation. We determined infarct size and in vivo aPC generation, analyzed gene expression by RNA sequencing, and performed immunoblotting and ELISA. The signaling-only 3K3A-aPC variant and inhibitory antibodies that blocked all or only the anticoagulant function of aPC were used to determine the role of aPC. Doses of fIIai and fXai that induced comparable anticoagulant effects resulted in a comparable reduction in infarct size. However, unbiased gene expression analyses revealed marked differences, including pathways related to sterile inflammation and inflammasome regulation. fXai but not fIIai inhibited sterile inflammation by reducing the expression of proinflammatory cytokines (IL [interleukin]-1β, IL-6, and TNFα [tumor necrosis factor alpha]), as well as NF-κB (nuclear factor kappa B) and inflammasome activation. This anti-inflammatory effect was associated with reduced myocardial fibrosis 28 days post–myocardial ischemia-reperfusion injury. Mechanistically, in vivo aPC generation was higher with fXai than with fIIai. Inhibition of the anticoagulant and signaling properties of aPC abolished the anti-inflammatory effect associated with fXai, while inhibiting only the anticoagulant function of aPC had no effect. Combining 3K3A-aPC with fIIai reduced the inflammatory response, mimicking the fXai-associated effect.

Conclusions:
We showed that specific inhibition of coagulation via direct oral anticoagulants had differential effects on gene expression and inflammation, despite comparable anticoagulant effects and infarct sizes. Targeting individual coagulation proteases induces specific cellular responses unrelated to their anticoagulant effect.
A New Basis for Judicial Review in Iraq
Authors: Mahmood Oday Talal 
Published: December 2020

Abstract
Article 2 of the Iraqi Constitution of 2005, which states that Iraq is a modern Islamic constitutional democracy, contains a ‘repugnancy clause’, prohibiting enactment of any law contrary to Islam’s settled rulings, principles of democracy, and rights guaranteed in the Constitution. This clause allows the Constitutional Court to invalidate laws that violate the Constitution. Currently, the Iraqi Federal Supreme Court’s method for determining whether a particular law is repugnant to the Constitution and Islamic settled rulings as per Article 2 is inconsistent and arbitrary. Here the core question is: What is the best way to successfully implement the Iraqi Constitution’s Repugnancy Clause? We propose an approach focusing on maqāṣid, the classical Islamic concept meaning Sharīʿah’s intent, purpose, or objectives that will also fulfil the other purposes of Article 2 to ensure that the law is consistent with the principles of democracy and the principles of human rights.
Louis XIII, Richard I, and the Duchess of Devonshire: Nineteenth-Century Jews in Fancy Dress Costume
Authors: Klein Michele 
Published: December 2020

Abstract
In the nineteenth century, fancy dress activities and their material record formed part of the mise-en-scène of the Jewish elite’s self-fashioning. Family photographs and press reports of Jews in costume cast new light on the visualization of wealthy Jews. These Jews actively participated in the fancy dress culture of the elites, a popular form of cultural expression that was deemed a powerful way to convey social messages. In the British Empire, Europe, and North America, affluent Jews negotiated their feelings of solidarity and difference among non-Jews. They explored and articulated their self-image and group identity by appropriating others’ history and culture in public and private dressing-up amusements. Fancy dress, this article argues, enabled Jews to question who they wanted to be and communicate their desires to their Jewish and non-Jewish peers.
Electoral Violence in Zanzibar: Drivers and Early Warning Mechanisms
Authors: Makulilo Alexander Boniface 
Published: December 2020

Abstract
Elections are an integral part of any democracy. They serve as a mechanism for legitimising a political system – its succession of government and leaders – for linking political institutions with voters, and for holding the elected government and leaders accountable to the electorate. Yet, due to the combative nature of competition for political power in high-stake contexts, elections may lead to violence. Usually this happens if key stakeholders anticipate the proceedings will not be free and fair, while those seeking to retain or gain political power show no qualms about resorting to extraordinary measures such as using force in order to win. Sometimes there exist underlying causes of electoral violence such as exclusion, inequality, or a history of ethnic tensions. Zanzibar, a semi-autonomous group of islands off the mainland coast of the United Republic of Tanzania, exhibits such a case whereby almost every one of its general elections has been marred with violence. Today, as the concern escalates over threats of immanent physical combat related to elections in so-called ‘advanced’ democracies, it is illuminating to revisit the drivers of electoral violence in Zanzibar, and to reconsider the efficacy of its early warning mechanisms, since the inception of Zanzibar’s multiparty politics in 1992.
From Madrasas to Organised Iftar Culture: Current Trends of Islamisation in Tanzania
Authors: Ng’atigwa Francis Xavier 
Published: December 2020

Abstract
In this study of current trends in the socio-religious life of Muslim communities in major urban centres and cities of Tanzania – Morogoro, Mwanza, and Dar es Salaam – ‘Islamisation’ denotes the strategies and activities that have been key to the spreading practice of Islam over the past three decades (1985-2015). In this period, Islam has embraced new approaches to social, political and economic change. This can be seen reflected in tangible ways as an institutionalized awakening of Islam consolidates faith, unifies sects, and promotes Qur’anic and hadith teachings in everyday life during this the post-Ujamaa era of Tanzania’s history.
The Urbanonimia of Ukraine in the Context of Decommunization
Authors: Demska Orysia , Levchuk Pavlo 
Published: December 2020

The Urbanonimia of Ukraine in the Context of DecommunizationThis article concerns the changing situation regarding toponyms in Ukraine, from the country’s regaining of independence to the present day. The article identifies two waves of decommunization. The first occured between the regaining independence in 1991 and 1995. The second wave began with the Revolution of Dignity in 2013–2014 and continues to this day. In the second part of the article, toponyms connected with Poland are presented and the reasons behind their creation are explained. Toponimia miejska na Ukrainie w kontekście dekomunizacjiArtykuł traktuje o sytuacji w zakresie zmian toponimów na Ukrainie od czasu odzyskania niepodległości do dnia dzisiejszego. Autorzy wyróżniają dwie fale dekomunizacji, pierwszą od odzyskania przez Ukrainę niepodległości w 1991 roku do 1995 roku. Druga fala rozpoczęła się wraz z rewolucją godności w latach 2013-2014 i trwa do dziś. W drugiej części artykułu przedstawiono toponimy związane z Polską, a także uzasadnienie ich powstania.
The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Authors: Malhi Gin S , Bell Erica , Bassett Darryl , Boyce Philip , Bryant Richard , Hazell Philip , Hopwood Malcolm , Lyndon Bill , Mulder Roger , Porter Richard , Singh Ajeet B , Murray Greg 
Published: December 2020

Objectives: To provide advice and guidance regarding the management of mood disorders, derived from scientific evidence and supplemented by expert clinical consensus to formulate s that maximise clinical utility. Methods: Articles and information sourced from search engines including PubMed, EMBASE, MEDLINE, PsycINFO and Google Scholar were supplemented by literature known to the mood disorders committee (e.g. books, book chapters and government reports) and from published depression and bipolar disorder guidelines. Relevant information was appraised and discussed in detail by members of the mood disorders committee, with a view to formulating and developing consensus-based recommendations and clinical guidance. The guidelines were subjected to rigorous consultation and external review involving: expert and clinical advisors, key stakeholders, professional bodies and specialist groups with interest in mood disorders. Results: The Royal Australian and New Zealand College of Psychiatrists mood disorders clinical practice guidelines 2020 (MDcpg2020) provide up-to-date guidance regarding the management of mood disorders that is informed by evidence and clinical experience. The guideline is intended for clinical use by psychiatrists, psychologists, primary care physicians and others with an interest in mental health care. Conclusion: The MDcpg2020 builds on the previous 2015 guidelines and maintains its joint focus on both depressive and bipolar disorders. It provides up-to-date recommendations and guidance within an evidence-based framework, supplemented by expert clinical consensus. Mood disorders committee: Gin S Malhi (Chair), Erica Bell, Darryl Bassett, Philip Boyce, Richard Bryant, Philip Hazell, Malcolm Hopwood, Bill Lyndon, Roger Mulder, Richard Porter, Ajeet B Singh and Greg Murray.
#ENT: Otolaryngology Residency Programs Create Social Media Platforms to Connect With Applicants During COVID-19 Pandemic
Authors: DeAtkine Andrew B. , Grayson Jessica W. , Singh Nikhi P. , Nocera Alexander P. , Rais-Bahrami Soroush , Greene Benjamin J. 
Published: December 2020

Objective: To determine which otolaryngology residency programs have social media platforms and to review which programs are utilizing platforms to advertise virtual open houses and virtual subinternships for residency applicants. Study Design: Cross-sectional study. Setting: The study was conducted online by reviewing all accredited otolaryngology residency programs in the United States participating in the Electronic Residency Application Service. Methods: Otolaryngology residency programs were reviewed for social media presence on Instagram, Twitter, and Facebook. Social media posts were evaluated for virtual open houses and virtual subinternships. Residency websites and the Visiting Student Application Service were evaluated for the presence of virtual subinternships. All data were collected between September 5, 2020, and September 9, 2020. This study did not require approval from the University of Alabama at Birmingham Institutional Review Board for Human Use. Results: Among 118 otolaryngology residency programs, 74 (62.7%) participate on Instagram, 52 (44.1%) participate on Twitter, and 44 (37.3%) participate on Facebook. Fifty-one Instagram accounts, 20 Twitter accounts, and 4 Facebook accounts have been created during 2020. Forty-two (36%), 30 (25.4%), and 15 (13%) programs are promoting virtual open houses on Instagram, Twitter, and Facebook, respectively. Two programs on the Visiting Student Application Service offered virtual subinternships. Seven residency program websites offered virtual subinternships. Nine, 6, and 1 program offered virtual subinternships on Instagram, Twitter, and Facebook, respectively. Conclusion: This study demonstrates that social media presence on Instagram and Twitter among otolaryngology residency programs has substantially grown in 2020 at a higher rate compared to previous years. These data suggest that otolaryngology residency programs are finding new ways to reach out to applicants amid an unprecedented type of application cycle due to the challenges presented by COVID-19. Many programs are advertising virtual open houses via social media platforms to connect with applicants, and a few programs are offering virtual subinternships to replace traditional subinternships.
Results of reconstructive interventions in patients with ischemic cardiomyopathy
Authors: Shipulin Vladimir M , Pryakhin Andrey S , Andreev Sergey L , Shipulin Vladimir V , Kozlov Boris N 
Published: December 2020

Background Effective treatment of patients with ischemic cardiomyopathy is one of the most difficult issues in contemporary cardiac surgery. The aim of this study was to evaluate the long-term effectiveness of reconstructive interventions on the left ventricle during chronic heart failure in patients with ischemic cardiomyopathy. Methods Between March 2013 and December 2017, 178 patients underwent surgical treatment for ischemic cardiomyopathy. Isolated coronary artery bypass grafting was compared with coronary artery bypass grafting with left ventricular reconstruction, using propensity score matching analysis. The primary endpoints of the study were hospital mortality and long-term survival. Results After propensity score matching, 29 pairs of patients were compared. The 30-day hospital mortality was comparable (6.8% versus 6.8%, p = 0.952), the average follow-up was 37.4 ± 12.6 months, with no statistically significant difference in mortality from all causes ( p = 0.352). After coronary artery bypass in combination with left ventricular reconstruction, patients showed a statistically significant decrease in clinical and functional indicators of chronic heart failure compared to those who had coronary artery bypass grafting alone, in terms of peak oxygen consumption (15.3 versus 13.5 mL·kg−1·min−1, p = 0.043) and N-terminal pro-brain natriuretic peptide concentrations (298.6 versus 461.1 pg·mL−1, p = 0.032). Conclusions Compared to isolated coronary artery bypass, coronary artery bypass in combination with left ventricular reconstruction for the treatment of ischemic cardiomyopathy leads to a significant decrease in the clinical and functional parameters of chronic heart failure in the long-term postoperative period.
The role, impact, and support of informal caregivers in the delivery of palliative care for patients with advanced cancer: A multi-country qualitative study
Authors: Adejoh Samuel Ojima , Boele Florien , Akeju David , Dandadzi Adlight , Nabirye Elizabeth , Namisango Eve , Namukwaya Elizabeth , Ebenso Bassey , Nkhoma Kennedy , Allsop Matthew J 
Published: December 2020

Background: Cancer is increasing in its prevalence in sub-Saharan Africa. Informal caregivers are key to supporting engagement and interaction with palliative care services, but limited literature on their role impedes development of supportive interventions. Aim: We aimed to understand the role, impact, and support of informal caregivers of patients with advanced cancer when interacting with palliative care services in Nigeria, Uganda, and Zimbabwe. Design: Secondary analysis of qualitative interview transcripts. The dataset was assessed for fit and relevance and framework approach was used. Setting/participants: Interview transcripts of informal caregivers included participants aged over 18 years of age recruited from palliative care services across participating countries. Results: A total of 48 transcripts were analyzed. Mean age was 37 (range 19–75) with equal numbers of men and women. Five themes emerged from the data: (1) caregivers are coordinators of emotional, practical, and health service matters; (2) caregiving comes at a personal social and financial cost; (3) practical and emotional support received and required; (4) experience of interacting and liaising with palliative care services; and (5) barriers and recommendations relating to the involvement of palliative care. Conclusions: The role of informal caregivers is multi-faceted, with participants reporting taking care of the majority of medical, physical, financial, and emotional needs of the care recipient, often in the face of sacrifices relating to employment, finances, and their own health and social life. Efforts to develop comprehensive cancer control plans in sub-Saharan Africa must take account of the increasing evidence of informal caregiver needs.
Assessing Functioning across Common Mental Disorders in Psychiatric Emergency Patients: Results from the WHODAS-2
Authors: Hoehne A. , Giguère C.-E. , Herba C. M. , Labelle R. 
Published: December 2020

Objective: Assessing global functioning in psychiatric emergency settings is important for clinicians to estimate severity of mental disorders, devise a treatment plan, and assess the evolution of their patients’ progression over time. The World Health Organization Disability Assessment Schedule-2.0 (WHODAS-2) measures psychological, social, and professional functioning and is recommended as a standardized instrument of choice for use in psychiatric settings. Yet, studies investigating disability profiles of mental disorders using the WHODAS-2 are scarce, and psychometric properties have not been evaluated in a psychiatric emergency context. We describe and compare WHODAS-2 (12-item version) scores across mental disorders (anxiety, mood, psychotic, personality, and substance abuse) in adults admitted to psychiatric emergency. Methods: Data from the Signature Bank were used. Participants admitted to psychiatric emergency completed the WHODAS-2 at admission ( n = 1,125). Mental disorders were evaluated by psychiatrists, and WHODAS-2 scores were compared across groups. Psychometric properties were evaluated using confirmatory factor analysis (CFA). Results: Higher mean WHODAS-2 scores were reported by those with anxiety, mood, and personality disorders ( P < 0.001) compared to other psychopathologies. The measure showed good internal consistency (global score α = 0.88; domain subscores α = 0.59 to 0.85) and acceptable goodness of fit indices in CFA confirming the original structure of WHODAS-2. Conclusions: Findings from this large-scale study could assist clinicians in interpreting WHODAS-2 scores in psychiatric populations and provide a more detailed portrait of disability profiles associated with different clinical diagnoses.
Adjunctive Garcinia mangostana Linn. (Mangosteen) Pericarp for Schizophrenia: A 24-Week Double-blind, Randomized, Placebo Controlled Efficacy Trial: Péricarpe d’appoint Garcinia mangostana Linn (mangoustan) pour la schizophrénie : un essai d’efficacité de 24 semaines, à double insu, randomisé et contrôlé par placebo
Authors: Turner Alyna , Baker Andrea , Dean Olivia M. , Walker Adam J. , Dodd Seetal , Cotton Susan M. , Scott James G. , Kavanagh Bianca E. , Ashton Melanie M. , Brown Ellie , McGrath John J. , Berk Michael 
Published: December 2020

Objectives: Garcinia mangostana Linn. (“mangosteen”) pericarp contains bioactive compounds that may target biological pathways implicated in schizophrenia. We conducted a double-blind randomized placebo-controlled trial evaluating the efficacy of adjunctive mangosteen pericarp, compared to placebo, in the treatment of schizophrenia. Methods: People diagnosed with schizophrenia or schizoaffective disorder ( Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition), recruited across 2 sites (Brisbane and Victoria, Australia), were randomized to receive 24 weeks of adjunctive mangosteen pericarp (1,000 mg/day) or matched placebo. The primary outcome measure was the Positive and Negative Symptom Scale total score. Secondary outcomes included positive and negative symptoms, general psychopathology, clinical global severity and improvement, participant reported overall improvement, depressive symptoms, functioning, quality of life, and safety data at 24 and 28 weeks (4 weeks postdiscontinuation). Data were collected from July 2016 to February 2019. Results: Baseline assessments were conducted on 148 people (mangosteen = 74, placebo = 74); data analyses were conducted on 136 (92%) participants with postbaseline data. The treatment group had significantly higher symptom severity compared to placebo, and both groups significantly improved on all symptom, functioning, and quality of life measures over time. No between-group differences were found for the rate of change between baseline and 24 or 28 weeks. Conclusion: Despite promising preclinical and clinical work, our results do not support mangosteen pericarp extract as an adjunctive treatment for schizophrenia or schizoaffective disorder.
Subjective Outcome Evaluation of a Positive Youth Development Program in Mainland China
Authors: Zhu Xiaoqin , Shek Daniel T. L. 
Published: December 2020

Objectives: This study validated a 36-item Subjective Outcome Evaluation Scale (SOES) and examined the effectiveness of a positive youth development (PYD) program entitled “Tin Ka Ping Positive Adolescent Training through Holistic Social Programs” (TKP P.A.T.H.S. Project) and implemented in mainland China in the 2016–2017 and 2017–2018 academic years. Methods: We collected data from 20,480 students from 30 secondary schools in mainland China on their views toward program quality, implementer quality, and program benefits based on the SOES. Results: The SOES possessed good factorial, convergent, discriminant, and concurrent validities as well as internal consistency. Besides, the student respondents were generally satisfied with the program quality, implementer quality, and program benefits. Consistent with our hypothesis, junior grade students had more positive perceptions than did senior grade students. Conclusion: Utilizing the client satisfaction approach, this study validated the SOES and highlighted the value of PYD programs exemplified by the TKP P.A.T.H.S. Program in a non-Western context.
Preparation for Future Care Needs in Middle-Aged and Older Adults: What Promotes Feeling of Preparedness?
Authors: Yun Stacy W. , Greenberg Jeff , Maxfield Molly 
Published: December 2020

Objective: To examine whether demographic, dementia-related, and control-related variables predict preparation for future care needs (PFCN) in a sample of middle-aged and older adults. PFCN is defined in this study as a self-perceived sense of preparedness for one’s own future care needs, including general awareness of future care needs, gathering relevant information, decision-making about care preferences, concrete planning, and non-avoidance of care planning. Methods: Participants ( N = 122; age 40 to 88 years: M = 65.83, SD = 9.80) completed self-report measures in an in-person study. Hierarchical multiple regression was calculated to predict PFCN. Results: Being female, having more positive dementia attitudes, higher attribution to powerful others for health condition(s), and more completed end-of-life (EOL) planning significantly predicted greater PFCN. Conclusion: Findings indicate a positive relationship between objective (completed EOL planning items) and subjective (PFCN) components of planning, thus highlighting the importance of taking concrete steps in EOL planning to yield greater feelings of preparedness, which has been associated with positive psychological outcomes.