bluuebunny/crossref_metadata_2025_split huggingface dataset:
High flow nasal oxygen therapy to avoid intubation in SARS-CoV-2 pneumonia: A multicenter retrospective study
Authors: Bonnet Nicolas , Martin Olivier , Boubaya Marouane , Levy Vincent , Ebstein Nathan , Karoubi Philippe , Lambiotte Yacine Tandjaoui , Meersch Guillaume Van Der , Oziel johanna , Soulie Marie , Ghalayini Mohamed , Winchenne Anais , Zahar Jean Ralph , Ahmed Passem , Gaudry Stéphane , Cohen Yves 
Published: October 2020

Abstract
Background:. The efficacy of high flow nasal canula oxygen therapy (HFNO) to prevent invasive mechanical ventilation (IMV) is not well established in severe coronavirus disease 2019 (COVID-19). The aim of this study was to compare the risk of intubation between two strategies of oxygenation (conventional oxygenation and HFNO) in critically ill COVID 19 patientsMethods: This was a multicenter retrospective case series witch took place in two intensive care units (ICU) of tertiary hospitals in the Paris region from March 11, to May 3, 2020. We enrolled consecutive patients hospitalized for COVID-19 and acute respiratory failure (ARF) who did not receive IMV at ICU admission. The primary outcome was the rate of IMV after ICU admission. Secondary outcomes were death at day 28 and day 60, length of ICU stay, ventilator-free days and number of patients with ventilator-free days >14 days. Data from the HFNO group were compared with those from the standard oxygen therapy (SOT) group.ResultsAmong 138 patients who met the inclusion criteria, 62 (45%) were treated with SOT alone, and 76 (55%) with HFNO. In HFNO group, 39/76 (51%) patients were intubated and 46/62 (74%) in SOT group. After using a standard logistic regression on the original sample, HFNO was associated with significantly lower rate IMV (OR [IC-95%] 0.37 [0.18 – 0.76] p = 0.007). After propensity score application, HFNO was still associated with a lower rate of intubation (OR [IC-95%] 0.31 [0.14-0.66] p = 0.002). Length of ICU stay and mortality at day 28 and day 60 did not significantly differ between HFNO and SOT groups after propensity score application. In a univariate analysis, ventilator-free days at days 28 was higher in HNFO group (21 days vs 10 days, p=0.005). The number of patients with ventilator free-days >14 days was higher in HFNO group after propensity score application (66% vs 39%; OR 3.91[1.91-7.99], p=0.0002).ConclusionsHigh flow nasal canula oxygen for ARF due to COVID-19 reduces the need for intubation.
Oryza sativa ObgC1 acts as a signaling hub that regulates DNA replication and ribosome biogenesis in chloroplast nucleoids
Authors: Chen Ji , Wang Li , Jin Xiaowan , Wan Jian , Zhang Lang , Je Byoung Il , Zhao Ke , Kong Fanlei , Huang Jin , Tian Mengliang 
Published: October 2020

Abstract
Background: The Spo0B-associated GTP-binding protein (Obg) GTPase, has diverse and important functions in bacteria, including morphological development, DNA replication and ribosome maturation. Homologs of the Bacillus subtilis Obg have been also found in chloroplast of Oryza sativa , but their primary roles remain unknown. Results: We clarify that OsObgC1 is a unique functional homolog of AtObgC. The mutant obgc1-d1 exhibited hypersensitivity to the DNA replication inhibitor hydroxyurea. Quantitative PCR results showed that the ratio of chloroplast DNA to nuclear DNA in the mutants was higher than that of the wild-type plants. After DAPI staining, OsObgC1 mutants showed abnormal nucleoid architectures. The specific punctate staining pattern of OsObgC1-GFP signal suggests that this protein localizes to the chloroplast nucleoids. Furthermore, loss-of-function mutation in OsObgC1 led to a severe suppression of protein biosynthesis by affecting plastid rRNA processing. It was also demonstrated through rRNA profiling that plastid rRNA processing was decreased in obgc1 -d mutants, which resulted in impaired ribosome biogenesis. The sucrose density gradient profiles revealed a defective chloroplast ribosome maturation of obgc 1-d1 mutants. Conclusion: Our findings here indicate that the OsObgC1 retains the evolutionarily biological conserved roles of prokaryotic Obg, which acts as a signaling hub that regulates DNA replication and ribosome biogenesis in chloroplast nucleoids.
Prognostic Prediction Models for Patients with Low Back Pain: Systematic Review Protocol
Authors: Silva Fernanda Gonçalves , Costa Leonardo Oliveira Pena , Hancock Mark J , Palomo Gabriele Alves , Costa Luciola da Cunha Menezes , Silva Tatiane da 
Published: October 2020

Abstract
Background: The prognosis of acute low back pain is generally favourable in terms of pain and disability; however, outcomes vary substantially between individual patients. Clinical prediction models help in estimating the likelihood of an outcome at a certain time point. There are existing clinical prediction models focused on prognosis for patients with low back pain. To date, there is only one previous systematic review summarising the discrimination of validated clinical prediction models to identify the prognosis in patients with low back pain of less than 3 months duration. The aim of this systematic review is to identify existing developed and/or validated clinical prediction models on prognosis of patients with low back pain of less than 3 months duration, and to summarise their performance in terms of discrimination and calibration. Methods: MEDLINE, Embase and CINAHL databases will be searched, from the inception of these databases until January 2020. Eligibility criteria will be: (1) prognostic model development studies with or without external validation, or prognostic external validation studies with or without model updating; (2) with adults aged 18 or over, with ‘recent onset’ low back pain (i.e. less than 3 months duration), with or without leg pain; (3) outcomes of pain, disability, sick leave or days absent from work or return to work status, and self-reported recovery; and (4) study with a follow-up of at least 12 weeks duration. The risk of bias of the included studies will be assessed by the Prediction model Risk Of Bias ASsessment Tool, and the overall quality of evidence will be rated using the Hierarchy of Evidence for Clinical Prediction Rules. Discussion: This systematic review will identify, appraise, and summarize evidence on the performance of existing prediction models for prognosis of low back pain, and may help clinicians to choose the best option of prediction model to better inform patients about their likely prognosis. Systematic review registration: PROSPERO reference number CRD42020160988
Development of A Mechanical Setup With Sensors to Determine Interfacial Phenomena Between Supersonic Steam Jet and Water
Authors: Khan Afrasyab , Sanaullah Khairuddin , Konstantinovich Spiridonov Evgeny , Fedorovna Darya Khabarova , Rigit Andrew Ragai Henry , Ullah Atta 
Published: October 2020

Abstract
A specially configured mechanical setup with sensors which was designed to record minimal and increased fluctuations in temperature as evidence of Kelvin–Helmholtz (KH) instabilities by means of LM35 sensors and data acquisition. The generation and spread of KH instabilities in steam and water was accomplished first time by following temperature profiles around the steam’s jet interface with the surrounding water. The supersonic steam was driven into the water in a vessel by means of a specially designed supersonic nozzle at pressure changing from 1.5 to 3.0 bars. Whereas, the temperature of the water in the cylindrical column varied from 30 o C to 60 o C with a change of 5 o C each time when the measurements were performed. The acquisition setup was able to record temperatures across the steam jet in the vessel at a rate of 1 ms, and it could also provide the temperature readings within the vessel. Axial and radial temperature profiles being obtained from 6 temperature sensors positioned along the steam jet, revealed the instabilities being occurred across the interface among the steam and the water, the instabilities spread along the axis towards the vessel wall. However, these instabilities were influenced considerably due to the variation in water temperature in the column, along with change in steam’s pressure. Also, instabilities were affected as well due to the change in viscosity of water owing to change in its temperature.
A Vehicular Electronic Image Stabilization System Based on A Gasoline Model Car Platform
Authors: Zhang Ning , Yang Yuan , Wu Jian-Hua , Zhao Zi-Qian , Yin Guo-Dong 
Published: October 2020

Abstract
The image sequence captured by the vehicular camera vibrates due to the vehicle vibration or harsh road conditions. It greatly affects the subsequent image processing. As a video processing technology, electronic image stabilization (EIS) can solve this problem effectively. In this paper, a gasoline model car platform is established, which has rich vibration characteristics. Besides, high unevenness roads are selected to make the vibration problem more prominent. Considering vehicle demand, feature point detection and matching algorithm is applied to match images in the process of establishing EIS. In addition, the algorithm of eliminating mismatched feature points and the adaptive Kalman filter (AKF) is improved to make them more suitable for vehicle application. The experimental results show that the EIS developed in this paper meets the real-time requirements and can work normally in harsh road conditions. Since the platform and working scenarios are more extreme than the normal conditions, the EIS developed in this paper has high portability in the environment perception system of smart car.
Risk Evaluation on Security Personnel Managing Illegal Detainees In A Makeshift Covid-19 Low Risk Quarantine and Treatment Center
Authors: Rahman Anita Abd , Moideen Mohd Arshil , Anuar Erlendawati Mohd , Mahabot Fuad Ridha , Mustapha Wan Mohd Harith Wan , Rusli Mohammad Farhan 
Published: October 2020

Abstract
Background: The COVID-19 pandemic situation in Malaysia has resulted in a whole country approach where a newly built makeshift low risk Covid-19 treatment centre was chosen to house all COVID-19 positive illegal immigrants. In view of the desperate situation the detained illegal immigrants were in as the risks of them behaving aggressively, taking hostage, running away and escaping from the treatment centre were high this is the first time ever other governmental, non-governmental and security agencies worked alongside healthcare personnel in a biological hazard treatment centre while the clinical management was of no different than any other clinical setup in the country. This paper entails risk evaluation that needs to be considered to all the security personnel working in this centre as there was no precedent of similar situation in the country.Methodology: This is a semi-quantitative and integrated type of hazard identification, risk assessment and risk control (HIRARC) approach where it incorporates risk rating and severity rating to cover four elements, which are people, property, environment, and reputation. Total scores range from 1 to 25 and was further categorized into low, medium and high risk in a color-coded representation. The assessment was done for two weeks from 27th May 2020 till 11th June 2020.Result & Discussion: Four types of occupational and security hazards identified were physical, biological, psychological and ergonomics hazards. this evaluation serves as a good planning tool in optimizing the risk mitigation measures among security personnel working in a biological hazardous environment. Physical hazards with possible violence and riot scored the highest risk while ergonomic issues had the lowest rating. Appropriate control measures to mitigate all the potential risks were appropriately implemented through a solid multi-agencies’ collaborative effort.Conclusion: The mapping combination of existing hazard, risk rating and control was able to facilitate organization to prioritise future planning. With the fluidity of the COVID-19 pandemic, periodical evaluation is recommended to meet dynamic changes such as demands for frontliner manpower strength, the number of existing detainee patients in ward and the evolution of the COVID-19 infection itself in order to maintain safety and security for all.
Sustained Remission After Haploidentical Bone Marrow Transplantation in a Child With Refractory Systemic Juvenile Idiopathic Arthritis
Authors: Morelle Guillaume , Castelle Martin , Pinto Graziella , Breton Sylvain , Bendavid Matthieu , Boussard Charlotte , Mouy Richard , Bader-Meunier Brigitte , Semeraro Michaela , Faye Albert , Cavazzana Marina , Neven Bénédicte , Blanche Stéphane , Quartier Pierre , Moshous Despina 
Published: October 2020

Abstract
Background: Some patients with systemic juvenile idiopathic arthritis (SJIA) and severe, refractory disease achieved remission through intensive immunosuppressive treatment followed by autologous hematopoietic stem cell transplantation (HSCT). However, disease relapsed in most cases. More recently selected SJIA patients received allogenic HSCT from a HLA-identical sibling or a HLA matched unrelated donor. While most transplanted patients achieved sustained SJIA remission off-treatment, the procedure-related morbidity was high.Case report: A girl presented SJIA since the age of 15 months with a severe disease course. She was refractory to the combination of methotrexate and steroids to anti-interleukin (IL)-1, then anti-IL-6, tumor necrosis factor alpha inhibitors, and thalidomide. Therefore, allogenic HSCT was considered. In the absence of any possible HLA matched donor, a multidisciplinary team carefully assessed risks and benefits of a transplant procedure with an alternative donor. Given the high disease burden and important treatment-related toxicity the indication for a haploidentical HSCT from her mother was validated. The patient received a T replete bone marrow graft at the age of 3.7 years. Conditioning regimen contained Rituximab, Alemtuzumab, Busulfan, and Fludarabine. Cyclophosphamide at D+3 and +4 post HSCT was used for graft-versus-host-disease prophylaxis, followed by Cyclosporin A and Mycophenolate Mofetil. Post HSCT complications included severe infections, grade 3 intestinal graft-versus-host-disease, autoimmune thyroiditis, and immune thrombocytopenia. Three years after HSCT, the child is alive and well, notwithstanding persistent hypothyroidy requiring substitution. Immune thrombocytopenia had resolved. Most importantly, SJIA was in complete remission, off immunosuppressive drugs.Conclusion: Allogenic HSCT may be a therapeutic option, even with a HLA haplo-identical alternative donor, in patients with inflammatory diseases such as SJIA. Despite increased experience with this treatment, the risk of life-threatening complications restrains its indication to selected patients with severe, refractory disease.
Comparison of Postoperative Complications Between Robotic and Laparoscopic Rectal Cancer Surgery
Authors: bo Tang , lei xiong , ai junhua , huang zhixiang , shi jun , li taiyuan 
Published: October 2020

Abstract
Objective: Robotic and laparoscopic surgery for rectal cancer have been applied in clinic for decades, nevertheless, which surgical approach has a lower rate of postoperative complications is still inconclusive. Therefore, the aim of this meta-analysis is to compare the postoperative complications between robotic and laparoscopic rectal cancer surgery based on randomized controlled trials.Methods: Randomized controlled trials (until May 2020) which compared robotic and laparoscopic rectal cancer surgery were searched through PubMed, EMbase, Cochrane library, CNKI, Wan Fang databases and CBM. Data regarding sample size, clinical and demographic characteristics, overall postoperative complications, and the incidence of anastomotic leakage、incision infection、bleeding、 ileus、respiratory complications、 urinary complications、unscheduled reoperation 、perioperative mortality were extracted. The results were analyzed using RevMan v5.3.Results: Seven randomized controlled trials which included 507 robotic and 516 laparoscopic rectal cancer surgery cases were included. Meta-analysis showed that the overall postoperative complications [Z=1.1，OR=1.18，95% CI (0.88-1.57), P=0.27], anastomotic leakage [Z=0.96, OR=1.27, 95% CI (0.78-2.08), P=0.34], incision infection [Z=0.18, OR=1.05, 95% CI (0.61-1.79), P=0.86], bleeding [Z=0.19, OR=0.89, 95% CI (0.27-2.97), P=0.0.85], ileus [Z=1.47, OR=0.66, 95% CI (0.38-1.15), P=0.14], respiratory complications [Z=0.84, OR=0.64, 95% CI (0.22-1.82), P=0.40], urinary complications [Z=0.66, OR=1.22, 95% CI (0.67-2.22),P=0.51], unscheduled reoperation [Z=0.14, OR=0.91, 95% CI (0.26-3.20), P=0.89], perioperative mortality [Z=0.28, OR=0.79, 95% CI (0.15-4.12), P=0.78] were similar between robotic and laparoscopic rectal surgery.Conclusion: Robotic surgery for rectal cancer was comparable to laparoscopic surgery with respect to postoperative complications.
Expectations and Needs of Socially Disadvantaged Patients for Navigational Support of Primary Health Care Services
Authors: Piemeu Carine Sandrine Ngo Bikoko , Loignon Christine , Dionne Émilie , Paré-Plante Andrée-Anne , Haggerty Jeannie , Breton Mylaine 
Published: October 2020

Abstract
Background: Primary healthcare is the main entry to the health care system for most of the population, even for specialized care. In 2014, it was estimated that about 25% of the population in Quebec (Canada) did not have a regular primary healthcare provider. In 2017, after the introduction of a centralized waiting list to enroll unattached patients with a family doctor, nearly 540,000 patients, many of whom were socially disadvantaged, remained on the list. Socially disadvantaged patients often have more health problems, more complex care needs, and more difficult to accommodate life situations (e.g. two or more jobs, no work accommodation, care responsibilities, low income, lack of social network). They can also lack the skills needed to navigate a constantly evolving and complex healthcare system and, consequently, misuse the system. To overcome this problem, a partnership of health system managers, family physician leaders, community agents, and researchers designed, implemented, and evaluated a navigational support initiative. This study aimed to describe and understand the expectations and needs of socially disadvantaged patients towards navigational support interventions to improve their access to healthcare. Methods: A descriptive qualitative study rooted in an international multi-site participatory study (IMPACT) was conducted with socially disadvantaged patients. Semi-structured individual face-to-face and telephone interviews were conducted with patients recruited at universal public primary health care clinics in Montérégie, some of whom received the evaluated navigational service. A thematic analysis was performed using NVivo 11 software. Results: Sixteen patients living in socially deprived contexts were recruited. Three main expectations of patients for navigational support were identified: communication expectations (support to understand providers and to be understood by them, provision of communication tips, and help to improve communication between providers); relational expectations (emotional or psychosocial support); and pragmatic expectations (information on available community resources, information about the clinic, tips and tools for medical appointments, and physical support to navigate the health care system).Conclusions: Our study contributes to the literature by identifying the many expectations socially disadvantaged patients have related to navigational services. This information can be used for navigational intervention design.
Prevalence of Overweight, Obesity and Metabolic Abnormalities Among 12-15 Year Age Group in an Urban City in Sri-Lanka
Authors: Kiridana Vasana , Karunaratne Ruchira , Ranasinghe Jagath Chaminda , Munasinghe Thilini Surenika , Karunadasa Umeshi Ishanthika , Vidanapathirana Gihani Udeshika , Abeygoonaratne Sameera Prabhath , Perera Madhawa , Bogahapitiya Anuradha , Jayathilaka Geethanjalee , Udupihilla Jeewani , Tennakoon Sampath , Abeysekera Chandra 
Published: October 2020

Abstract
ObjectivesTo determine the prevalence of childhood overweight, obesity and metabolic abnormalities among children aged 12-15 years within the schools in Kandy Municipality area, Sri Lanka. DesignCross- sectional observational study.SettingRandomly selected schools in Kandy municipality areaMethodsThe anthropometric measurements of 1766 school children were taken and those who were overweight or obese were recruited for further evaluation of metabolic abnormalities.ResultsThere were 1053 (59.62%) boys and 713 (40.37%) girls of whom 258 (14.60%) were overweight or obese (7.81% overweight and 6.79% obese). This included 106 girls of whom, 64 were overweight and 42 were obese and 152 boys of whom, 74 and 78 were overweight and obese respectively. Central obesity was seen in 16.93% and 5.01% of them had normal body mass index. Eighty-five children out of the 258 with body mass index > 85th percentile reported for further evaluation and the prevalence of metabolic syndrome among them was 11.67% (5 girls and 5 boys). When borderline and abnormal levels of lipids were taken together, more than 50% of overweight and obese children were found to have dyslipidaemia. Elevated Alanine Amino Transaminase and Aspartate Amino Transaminase levels were reported in 33 (38.82%) and 7 (8.24%) respectively. Evidence of fatty liver was present in 34.69% based on abdominal ultra sound scan findings.ConclusionWhile prevalence rates of overweight, obesity and metabolic syndrome are comparable with other urban settings in the country as well as neighbouring countries in Asia, the study highlights the detection of lipid abnormalities suggestive of familial hyperlipidaemia which warrants further evaluation. NAFLD is also identified as a significant comorbidity. Central obesity is underestimated by British standards.
Effects of Short-Term Methionine and Cysteine Restriction and Enrichment With Polyunsaturated Fatty Acids on Oral Glucose Tolerance, Plasma Amino Acids, Fatty Acids, Lactate and Pyruvate: Results From a Pilot Study
Authors: Olsen Thomas , Øvrebø Bente , Turner Cheryl , Bastani Nasser , Refsum Helga , Vinknes Kathrine 
Published: October 2020

Abstract
ObjectiveIn this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cyslow+PUFA, n = 7) or with high contents of methionine, cysteine and SFA (Met/Cyshigh+SFA, n = 7). The objective was to describe the short-term responses in the oral glucose tolerance, amino acid profile, total fatty acid profile, pyruvate and lactate following a Met/Cyslow+PUFA diet vs. Met/Cyshigh+SFA.ResultsThe diet groups consisted of five women and two men, aged 20-38 years. After the 7-d intervention median pre- and post-oral glucose tolerance test (OGTT) glucose concentrations were 5 mmol/L and 4 mmol/L respectively, in the Met/Cyslow+PUFA group. In the Met/Cyshigh+SFA group median pre- and post-OGTT glucose concentrations were 4.8 mmol/L and 4.65 mmol/L after the 7-d intervention. The response in the amino acid profile were similar in both groups during the intervention with the exception of serine. Fatty acids decreased from baseline to day 7 in both groups. Plasma lactate and pyruvate were similar for both groups with an increase to day 3 before approaching baseline values at day 7.Trial registrationClinicalTrials.gov: NCT02647970, registration date: 6 January 2016