bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Ponticulus Ethmoidalis: A Newly Appreciated Anatomic Landmark in Endoscopic Sinus Surgery
Authors: Bolger William E. , Ishii Masaru , Solaiyappan Meiyappan , Zinreich S. James 
Published: December 2019

Introduction: Ethmoid sinus anatomy is so variable it has been referred to as a “labyrinth.” Accordingly, this provides a challenge for surgeons performing ethmoidectomy. Identifying consistent anatomic features or landmarks within the ethmoid sinus can aid surgeons performing sinus surgery. The goal of this investigation was to determine if subtle anatomic features are consistently present within the retrobullar recess and could potentially serve as a reliable landmark for surgeons performing ethmoid surgery. Materials and Methods: Ethmoid sinus anatomy was studied in 60 sinonasal complexes through several methods including gross anatomic dissection, endoscopic dissection and 3-D CT stereoscopic imaging. Results: Review of gross sagittal sinonasal specimens revealed that the retrobullar recess was present in all specimens and a tissue bridge was noted emanating from the basal lamella deep within the retrobullar recess in 23/24 gross sagittal specimens; in 1/24 specimens it was quite small or difficult to appreciate. In the radiographic analysis, the tissue bridge was noted in 17/18, in 1/18 it was not appreciated. In the endoscopic dissections it was noted in 17/18, in 1/18 it was small or not appreciated. Conclusion: The small tissue bridge, or ponticulus within the retrobulbar recess was seen in nearly all ethmoid sinuses studied leading us to venture that could be used in surgery to orient surgical dissection through the basal lamella into the posterior ethmoid region.
Comparison of homeless clinic attenders with and without psychotic illness
Authors: Nielssen Olav , Jones Naidene , Foung Hayden , Nielssen Amelia , Staples Lauren , Large Matthew 
Published: December 2019

Aim: To compare the characteristics of clinic attenders in inner city homeless hostels with and without a diagnosed psychotic illness. Method: A cross-sectional study of homeless people attending psychiatric clinics in three inner city homeless hostels over a period of 8 years. The demographic characteristics, comorbid conditions, pathway to homelessness and pattern of homelessness of clinic attenders with a diagnosis of psychosis were compared with those who were not known to have psychotic illness. Results: 2389 homeless people attended one or more of the clinics in the 8 years of the study, of whom 1222 (51.2%) had a diagnosed psychotic illness, mostly schizophrenia. Those with psychosis were less likely to have been married (23.2% vs 45.5%), were less likely to have worked for more than a year (47.4% vs 74%) and were more likely to have been discharged from hospital to homelessness, to receive the Disability Support Pension (72.2% vs 38.3%), or be under financial management orders (12.0% vs 2.6%). Homeless people with psychosis were also more likely to have been homeless for more than a year, sleep in the open, and were less likely to have a current substance use disorder, problem gambling or a history of early life or recent trauma. A high proportion of those with psychosis (29.5%) had been released from prison to homelessness and a surprising number (22%) reported the loss of public housing tenancy. Conclusion: The results demonstrate the homeless with psychotic illness are particularly disabled and disadvantaged, often have multiple comorbid conditions, and many have been unable to maintain public housing tenancy. The inability of many of the homeless mentally ill to maintain public housing tenancy suggests the need for more supported housing to help the chronically homeless with psychotic illness maintain tenancy.
Influence of participation in multiple school-based health promotion programmes on students’ health
Authors: Kang EunKyo , Yun Young Ho 
Published: December 2019

Objective: The objective of this study was to investigate the impact of experiencing diverse, multi-dimensional health promotion programmes in school on students’ self-reported health status. Design: Cross-sectional design. Methods: We surveyed 2,568 students from 15 middle schools and 15 high schools in Korea between August 2014 and January 2015. Self-reported information related to health status, attendance at physical, social, mental or spiritual health promotion programmes, and socio-demographics was collected and analysed. Results: Male students, students aged 15 and below, and students living in rural areas were more satisfied with their health status. Regardless of programme type, the number of health promotion programmes attended correlated positively with better overall health status ( p < .001–.032). Attending physical health promotion programmes was significantly associated with physical, mental, spiritual and overall health (adjusted odds ratio [aOR] = 1.28–1.40). Attending mental health programmes was significantly related to all aspects of health status (aOR = 1.49–2.17), and participating in social health programmes was significantly related to all aspects of health status except physical and social health (aOR = 1.36–1.67). Participation in spiritual health programmes was related to spiritual and overall health (aOR = 1.33, 1.58). In hierarchical regression analyses, health promotion programme attendance was independently associated with subjective health status after controlling for differences between schools. Conclusion: Participation in health promotion programmes was found to be related not only to the targeted health status but also to other aspects of subjective health.
Medicaid Capitation Payments by State
Authors: Hsia David C. 
Published: December 2019

Congress has repeatedly proposed changing Medicaid from an entitlement to a block grant. Each state would receive a fixed amount instead of a Federal payment influenced by state decisions on eligibility, coverage, and pricing. This paper uses existing data series to simulate redistributing the annual $353 billion Federal payment among Medicaid’s 56 state (and territorial) programs. Capitation by general population would shift $52 billion, mainly from large Northeastern and West Coast states to large Southern and Mountain states. Capitation by population below the Federal Poverty Line (FPL) would shift $60 billion in a similar pattern. Policymakers should understand likely state-to-state effects when considering Medicaid legislation. States could then prepare for possible changes in their Federal payment for Medicaid.
Clinical features and their effect on outcomes of patients with triple negative breast cancer with or without lymph node involvement
Authors: Sobočan Monika , Turk Maja , Čater Pija , Sikošek Nina Čas , Crnobrnja Bojana , Takač Iztok , Arko Darja 
Published: December 2019

Objective Clinical and pathological characteristics of triple negative breast cancer (TNBC) treatment are required for escalation or de-escalation of treatment because of a lack of druggable targets. This study aimed to identify the factors affecting the risk of disease recurrence and disease-related death in patients with TNBC. Methods Patients with TNBC who were treated at the University Medical Centre Maribor between January 2010 and December 2017 were studied. Clinical and pathological data were analyzed using multivariate analysis and non-parametric tests. Subgroup analysis was performed to examine additional factors that affect 5-year overall survival (OS) and recurrence-free survival. Results Multivariate analysis showed that tumor size and the lymph node ratio (LNR) were significant risks in our population. Better discrimination of patients at risk of a shorter recurrence-free survival and OS was achieved by using the LNR. Only lymphovascular invasion was significant for predicting 5-year OS. Conclusion For risk-based decision-making systems, the LNR is useful for discriminating between high- and low-risk patients with TNBC.
Identification of differentially expressed genes between the colon and ileum of patients with inflammatory bowel disease by gene co-expression analysis
Authors: Zhang Yuting , Shen Bo , Zhuge Liya , Xie Yong 
Published: December 2019

Objective We aimed to identify differentially expressed genes (DEG) in patients with inflammatory bowel disease (IBD). Methods RNA-seq data were obtained from the Array Express database. DEG were identified using the edgeR package. A co-expression network was constructed and key modules with the highest correlation with IBD inflammatory sites were identified for analysis. The Cytoscape MCODE plugin was used to identify key sub-modules of the protein–protein interaction (PPI) network. The genes in the sub-modules were considered hub genes, and functional enrichment analysis was performed. Furthermore, we constructed a drug–gene interaction network. Finally, we visualized the hub gene expression pattern between the colon and ileum of IBD using the ggpubr package and analyzed it using the Wilcoxon test. Results DEG were identified between the colon and ileum of IBD patients. Based on the co-expression network, the green module had the highest correlation with IBD inflammatory sites. In total, 379 DEG in the green module were identified for the PPI network. Nineteen hub genes were differentially expressed between the colon and ileum. The drug–gene network identified these hub genes as potential drug targets. Conclusion Nineteen DEG were identified between the colon and ileum of IBD patients.
“It’s Sexual Assault. It’s Barbaric”: Strip Searching in Women’s Prisons as State-Inflicted Sexual Assault
Authors: Hutchison Jessica 
Published: December 2019

Rationale:In the era of the #MeToo movement, sexual assault has emerged from the shadows to become a dominant topic of public and scholarly conversation. Yet women in prison have largely been left out of these conversations, particularly as it relates to their experiences of being strip searched.Method:Five cisgender women were interviewed about their experiences being strip searched while imprisoned in Canada.Findings:Findings demonstrate that strip searching is a form of sexual assault. Women were unable to say “no” to being strip searched due to power imbalances and fear of serious consequences. Experiences of prior sexual victimization made being strip searched particularly harmful.Discussion:This study shows that structural violence occurring behind prison walls is a replication of structural violence occurring in the community. That strip-searching policies and practices are developed and implemented by the state necessarily means it is state-inflicted sexual assault. I theorize that strip searching is not understood as sexual assault because imprisoned women are relegated to a class of subhumanness for which humane treatment is not required.Implications:Implications for reducing the harms of strip searching are discussed, aimed at moving toward the abolishment of strip searching as a practice in women’s prisons.
Has the Global Financial Crisis Changed the Market Response to Credit Ratings? Evidence from an Emerging Market
Authors: Krishnan Kaveri , Basu Sankarshan , Thampy Ashok 
Published: December 2019

This article analyses the differential market response to credit rating revisions in the pre- and post-global financial crisis (GFC) period using data from India. By reviewing the stock price reaction to the announcement of long-term rating changes during the period 1996–2015, the study finds evidence that the stock price reacted less to rating announcements after the GFC of 2008. However, the difference in the cumulative abnormal returns before the GFC and after the GFC is not statistically significant. JEL codes: G240, G010, G140
Pomalidomide desensitization for hypersensitivity: A case report
Authors: Park Jiyeon J , Huang Esther , Monteleone Catherine A , Kane Michael P , Cooper Dennis L 
Published: December 2019

Introduction Pomalidomide is an immunomodulating agent that is used to treat relapsed and/or refractory multiple myeloma. Although the incidence of hypersensitivity with pomalidomide is not well documented, the most common type of hypersensitivity involves a cutaneous reaction. Previous reports have successfully utilized a desensitization protocol in patients who developed hypersensitivity to pomalidomide. Here we describe a case of a patient who developed urticaria on pomalidomide and successfully underwent a desensitization using the previously reported method in a case report. Case report A 68-year-old woman with relapsed multiple myeloma and no known drug allergies developed urticaria a day after taking the first dose of pomalidomide. Management and Outcome The patient underwent a 10-step desensitization process in the medical intensive care unit without any reported adverse events. The following day in the medical intensive care unit, the patient was able to tolerate a full dose of pomalidomide with no further reactions and was discharged with instructions to take a full dose of pomalidomide daily for 21 days out of a 28-day cycle. The patient was followed up in the outpatient clinic and noted no further reactions from pomalidomide at the three-month visit. Discussion The 10-step desensitization protocol with pomalidomide was well tolerated in the patient with hypersensitivity to pomalidomide. Whether this approach would work in patients with more severe reactions such as anaphylaxis and angioedema is still unknown.
Measurement of the leak rate of masks used for anticancer drug handling using a mask fitting tester
Authors: Sato Junya , Yamawaki Yuki , Ito Masako , Endo Megumi , Tanaka Rei , Shino Michihiro 
Published: December 2019

Background Exposure to inhalation of anticancer drugs is frequent in anticancer drug handling. Using an activated carbon mask with the ability to remove particulates and vapors of anticancer drugs may be effective. Mask fitting performance is important, because low fitting performance leads to inhalation via bypassing the mask filter (leak). This study evaluated the leak rate of multiple-shaped masks. Methods Activated carbon and nonactivated carbon masks of the pleated-type (like surgical mask) and cup-type were used. Four pharmacists wore the masks and a fitting tester was employed. The particle reduction rate of particles in ambient air was calculated using: particle count (outside - inside)/outside × 100 (%). Leak rate was calculated as the difference in the particle reduction rate due to the presence or the absence of a seal in the mask surroundings. Results Reduction rates of the pleated-type nonactivated carbon mask and the pleated-type activated carbon mask were 14.8% and 34.8% (mean). These values significantly increased to 85.6% and 83.3% upon sealing the mask surroundings. Particle reduction rates of the cup-type nonactivated carbon mask and activated carbon mask were 99.3% and 33.6%. When mask surroundings were sealed, these values were 99.6% and 39.2%. Leak rates of pleated-type nonactivated carbon mask, pleated-type activated carbon mask, cup-type nonactivated carbon mask, and cup-type activated carbon mask were 70.8%, 48.5%, 0.3%, and 5.6%, respectively. Conclusion A difference was found in the leak rate between masks used in anticancer drug handling. Based on the low leak rate, the cup-type activated carbon mask was thought to be effective.
Evaluation of aqueous humor and serum cortistatin levels in diabetic patients with and without diabetic retinopathy
Authors: Balbaba Mehmet , Ulaş Fatih , Erdağ Murat , Yıldırım Hakan , Çeliker Ülkü , Aydın Süleyman 
Published: December 2019

Purpose: To evaluate the aqueous humor and serum cortistatin levels in diabetic patients with and without diabetic retinopathy and its relationship with various metabolic markers that have been reported to be associated with diabetes mellitus. Methods: The current study included 20 diabetes mellitus patients with diabetic retinopathy, 20 diabetes mellitus patients without diabetic retinopathy, and 20 healthy control subjects with the same sex and age characteristics. Aqueous humor and serum cortistatin, fasting blood glucose, hemoglobinA1c, 25-hydroxyvitamin D levels, blood lipid profiles, and body mass index were measured in all subjects. Results: In diabetic patients with and without diabetic retinopathy and in healthy control subjects, the mean aqueous humor cortistatin levels were 25.55 ± 2.03, 27.71 ± 2.01, and 32.76 ± 3.43 ng/mL, respectively. Likewise, the mean serum cortistatin levels were 6.16 ± 1.08, 6.57 ± 1.00, and 7.56 ± 1.51 ng/mL, respectively. Aqueous humor cortistatin levels were decreased in diabetic patients with and without diabetic retinopathy when compared to healthy controls ( p < 0.001). Although aqueous humor cortistatin levels tended to be reduced in diabetic patients with diabetic retinopathy, the difference was not statistically significant between diabetic patients with and without diabetic retinopathy ( p = 0.147). Serum cortistatin levels were not statistically significant between diabetic patients with and without diabetic retinopathy and healthy control subjects ( p = 0.166). Body mass index, fasting blood glucose, and hemoglobinA1c levels were significantly different between the groups ( p < 0.05 for all parameters tested). Conclusion: Aqueous humor cortistatin levels were decreased in diabetic patients with and without diabetic retinopathy. The results suggest that a local decrease in the amount of cortistatin may play a role in the pathogenesis of diabetic retinopathy.
Cooking Online With a Chef: Health Professionals’ Evaluation of a Live Culinary Coaching Module
Authors: Polak Rani , Finkelstein Adi , Paganoni Sabrina , Welch Rob , Silver Julie K 
Published: December 2019

Introduction: Cooking Online With a Chef (COWC) is a live, telemedicine module delivered by a health coach chef to participants who log in from their home kitchen. Our purpose is to identify health professionals’ perceptions on its educational value and to determine feasibility for clinical practice. Method: Sixty-four health care professionals participated in a 75-minute COWC module as active participants during a live remote Continuing Medical Education (CME) program that includes five 75-minute telemedicine sessions. Post-program questionnaire elicited feedback on the module educational value and relevance to clinical practice through Likert-type scale and open-ended questions. This report presents descriptive analysis of the Likert-type scale questions and thematic qualitative analysis of the open-ended question. Results: Seventy percent of health care professional participants rated the quality of the COWC module as either very good or excellent, and 73% rated its relevance to clinical practice as very good or excellent. Open-ended question feedback showed appreciation of the learning experience with specific suggestions about how to improve participants’ preparation for the module. Conclusions: The COWC telemedicine module was well received by self-selected health care professionals. Future studies are being planned to determine the efficacy of the module on patients’ nutrition.
A phase II study of the efficacy and safety of the MET inhibitor capmatinib (INC280) in patients with advanced hepatocellular carcinoma
Authors: Qin Shukui , Chan Stephen Lam , Sukeepaisarnjaroen Wattana , Han Guohong , Choo Su Pin , Sriuranpong Virote , Pan Hongming , Yau Thomas , Guo Yabing , Chen Minshan , Ren Zhenggang , Xu Jianming , Yen Chia-Jui , Lin Zhong-Zhe , Manenti Luigi , Gu Yi , Sun Yongjian , Tiedt Ralph , Hao Lu , Song Wenjie , Tanwandee Tawesak 
Published: December 2019

Background: The objectives of this phase II study were to determine the clinical activity of the MET tyrosine kinase inhibitor capmatinib (INC280) in patients with MET-dysregulated advanced hepatocellular carcinoma (HCC) and to assess the safety, pharmacokinetics, and correlation of biomarkers with the response. Methods: This phase II, open-label, single-arm study evaluated twice daily (BID) oral capmatinib in a dose-determining stage, utilizing a Bayesian Logistic Regression Model (BLRM) subject to Escalation with Overdose Control criteria, safety, pharmacokinetics, and pharmacodynamic information to determine a recommended dose for expansion (RDE) evaluating efficacy in patients with MET-dysregulated HCC. Results: A total of 38 patients received treatment. In the dose-determining stage, patients received capmatinib 300 mg BID capsules ( n = 8), and in the expansion, patients received 600 mg BID capsules ( n = 28) or 400 mg BID tablets ( n = 2) based on the BLRM and other relevant clinical data. No predefined qualifying adverse events (AEs) were observed during the first 28 days of treatment, and the RDE was 600 mg BID capsules (equivalent pharmacokinetics to 400 mg BID tablets). The most common any causality AEs were nausea (42%), vomiting (37%), and diarrhea (34%). In the expansion stage, in a subgroup of 10 patients with MET-high HCC, the overall response rate was 30%, including 1 durable complete response (>600 days) and 2 partial responses [1 durable (>600 days)]. Conclusions: Single agent capmatinib at the RDE is tolerable with a manageable safety profile. Antitumor activity was seen in a subset of patients with MET-dysregulated (MET-high) HCC. Trial registration: ClinicalTrials.gov: NCT01737827. https://clinicaltrials.gov/ct2/show/NCT01737827
An RB-1 loss of function gene signature as a tool to predict response to neoadjuvant chemotherapy plus anti-HER2 agents: a substudy of the NeoALTTO trial (BIG 1-06)
Authors: Risi Emanuela , Biagioni Chiara , Benelli Matteo , Migliaccio Ilenia , McCartney Amelia , Bonechi Martina , Guarducci Cristina , Hilbers Florentine , Di Cosimo Serena , Huober Jens , Romagnoli Dario , Boccalini Giulia , Vitale Stefania , Sotiriou Christos , Biganzoli Laura , Di Leo Angelo , Malorni Luca 
Published: December 2019

Background: Chemotherapy added to anti-HER2 agents (H) is the treatment of choice in patients with HER2+ early breast cancer. However, HER2+ tumours are clinically and biologically heterogeneous, and treatment response varies significantly by hormone receptor (HR) status and molecular subtype. Predictive biomarkers are needed in this context. This study assessed whether an RB-1 loss of function gene signature (RBsig) is predictive of response to neoadjuvant chemotherapy in combination with trastuzumab, lapatinib or both, within the NeoALTTO trial. Methods: We collected RNA-sequencing data from pretreatment biopsies derived from the NeoALTTO trial. RBsig expression was computed retrospectively and correlated with pathological complete response (pCR) using receiver-operating characteristic (ROC) curves. The RBsig was dichotomised as High/Low in correspondence to the 25th percentile. Reported p values resulted from Fisher’s exact test. Results: Of 455 NeoALTTO patients, 244 were eligible for this substudy (HR+ n = 129; HR− n = 115). Overall, pCR rate was significantly higher in patients with RBsig High tumours than those with RBsig Low (35% versus 18% respectively; p = 0.01). The area under the ROC curve (AUC) was 0.60 (95% CI 0.52–0.67). A remarkably low pCR rate of 11% was seen in HR+/RBsig Low patients versus 28% in HR+/RBsig High. Conclusions: These results indicate RBsig may add valuable information to HER2 and HR expression, which may in turn inform treatment choices. HR+/HER2+/RBsig Low breast cancers exhibited the poorest pathological response following chemotherapy plus H. Accordingly, in such patients, endocrine therapy in combination with H and, possibly, a CDK4/6 inhibitor, may potentially prove to be a more effective treatment.