bluuebunny/crossref_metadata_2025_split huggingface dataset:
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway
Authors: Sun Xiaohong , Huang Kaipeng , Haiming Xiao , Lin Zeyuan , Yang Yan , Zhang Meng , Liu Peiqing , Huang Heqing 
Published: June 2020

Abstract
Hyperglycemia-induced renal epithelial-to-mesenchymal transition (EMT) is a key pathological factor in diabetic renal tubulointerstitial fibrosis (RIF). Our previous studies have shown that connexin 43 (Cx43) activation attenuated the development of diabetic renal fibrosis. However, whether Cx43 regulates the EMT of renal tubular epithelial cells (TECs) and the pathological process of RIF under the diabetic conditions remains to be elucidated. In the present study, we identified that Cx43 protein expression was down-regulated in the kidney tissues of db/db mice as well as in high glucose (HG)-induced NRK-52E cells. Overexpression of Cx43 improved renal function in db/db spontaneous diabetic model mice, increased SIRT1 levels, decreased hypoxia-inducible factor (HIF)-1α expression, and reduced production of EMT markers and extracellular matrix (ECM) components. Additionally, Cx43 overexpression inhibited the EMT process and reduced the expression of ECM components such as fibronectin (FN), Collagen I, and Collagen IV in HG-induced NRK-52E cells, whereas Cx43 deficiency had the opposite effects. Mechanistically, Cx43 in a carboxyl-terminal signal transduction-dependent manner could up-regulate SIRT1 expression and enhance SIRT1-dependent deacetylation of HIF-1α to reduce HIF-1α activity, which eventually ameliorated renal EMT and diabetic RIF. Our study indicates the essential role of Cx43 in regulating renal EMT and diabetic RIF via regulating the SIRT1-HIF-1α signaling pathway and provides an experimental basis for Cx43 as a potential target for diabetic nephropathy (DN).
Energy dependent morphology of the pulsar wind nebula HESS J1825-137 withFermi-LAT
Authors: Principe G. , Mitchell A. M. W. , Caroff S. , Hinton J. A. , Parsons R. D. , Funk S. 
Published: June 2020

Aims.Taking advantage of more than 11 years ofFermi-LAT data, we perform a new and deep analysis of the pulsar wind nebula (PWN) HESS J1825-137. Combining this analysis with recent H.E.S.S. results we investigate and constrain the particle transport mechanisms at work inside the source as well as the system evolution.Methods.The PWN is studied using 11.6 years ofFermi-LAT data between 1 GeV and 1 TeV. In particular, we present the results of the spectral analysis and the first energy-resolved morphological study of the PWN HESS J1825-137 at GeV energies, which provide new insights into theγ-ray characteristics of the nebula.Results.An optimised analysis of the source returns an extended emission region larger than 2°, corresponding to an intrinsic size of about 150 pc, making HESS J1825-137 the most extendedγ-ray PWN currently known. The nebula presents a strong energy dependent morphology within the GeV range, moving from a radius of ∼1.4° below 10 GeV to a radius of ∼0.8° above 100 GeV, with a shift in the centroid location.Conclusions.Thanks to the large extension and peculiar energy-dependent morphology, it is possible to constrain the particle transport mechanisms inside the PWN HESS J1825-137. Using the variation of the source extension and position, as well as the constraints on the particle transport mechanisms, we present a scheme for the possible evolution of the system. Finally, we provide an estimate of the electron energy density and we discuss its nature in the PWN and TeV halo-like scenario.
Hospitalization Duration Following Uncomplicated Cesarean Delivery: Predictors, Facility Variation, and Outcomes
Authors: Federspiel Jerome J. , Suresh Sunitha C. , Darwin Kristin C. , Szymanski Linda M. 
Published: June 2020

Objectives This study was designed to: (1) characterize stay duration following cesarean delivery, (2) ascertain whether facility variation exists, and (3) determine whether shorter stays are associated with rates of readmission or costs.
Study Design The 2017 Nationwide Readmissions Database was used to identify uncomplicated cesarean deliveries. Hierarchical logistic regression was used to assess for facility variation in percentage of patients discharged within 2 days. Similar models were used to assess for associations between probability of readmission within 30 days and facility-level rates of discharge within 2 days.
Results In total, 456,312 patients from 1,535 hospitals were included. The median facility discharged 46.8% of patients within 2 days, with the 25th percentile of hospitals 23.7% and the 75th percentile 71.2%. In adjusted regression, there was significant facility heterogeneity (p < 0.0001). The overall readmission rate was 1.7%, and proportion of patients discharged within 2 days of cesarean delivery was not associated with readmission probability (adjusted relative risk: 1.02, confidence interval: 0.90–1.16), but was associated with lower inpatient costs (adjusted incremental cost: $111, confidence interval: −181 to −41).
Conclusion Unexplained facility variation in percentage of patients discharged within 2 days of cesarean delivery was not associated with differences in readmissions.
Key Points
Risk Factors for Mortality in Acute Aortic Dissection Type A: A Centre Experience Over 15 Years
Authors: Salem Mohamed , Friedrich Christine , Thiem Alexander , Huenges Katharina , Puehler Thomas , Cremer Jochen , Haneya Assad 
Published: June 2020

Abstract
Introduction Acute aortic dissection Type A (AADA) is still associated with a high mortality rate and frequent postoperative complications. This study was designed to evaluate the risk factors for mortality in AADA patients.
Patients and Methods This retrospective analysis included 344 consecutive patients who underwent surgery for AADA in moderate hypothermic circulatory arrest (20–24°C nasopharyngeal) between 2001 and 2016.
Results The 30-day mortality rate was 18%. Nonsurvivors were significantly older (65.7 ± 12.0 years vs. 62.0 ± 12.5 years; p = 0.034) with significantly higher Euro-score II [15.4% (6.6; 23.0) vs. 4.63% (2.78; 9.88); p < 0.001)]. Intraoperatively, survivors had statistically shorter cardiopulmonary bypass times [163 (134; 206) vs. 198 min (150; 245); p = 0.001]. However, the hypothermic circulatory arrest time was similar between both groups. Postoperatively, the incidence of acute kidney injury (AKI) (55.9 vs. 15.2%; p < 0.001), stroke (27.9 vs. 12.1%; p = 0.002) and sepsis (18.0 vs. 2.1%; p < 0.001) were significantly higher among nonsurvivors. The multi-variable logistic regression confirmed that older age, previous cardiac surgery, preoperative cardiopulmonary resuscitation (CPR), blood transfusion and postoperative acute kidney injury (AKI) were independent risk factors for mortality.
Conclusion Our analysis suggested that the reason for mortality was multifactorial, especially age, previous cardiac surgery, CPR, transfusion, as well as postoperative AKI were considered risk factors for mortality.
What Is the Best Method to Achieve Safe and Precise Stent-Graft Deployment in Patients Undergoing TEVAR?
Authors: Gottardi Roman , Berger Tim , Voetsch Andreas , Winkler Andreas , Krombholz-Reindl Philipp , Farkouh Andre , Kondov Stoyan , Rylski Bartosz , Sodian Ralf , Czerny Martin 
Published: June 2020

AbstractThoracic endovascular aortic repair (TEVAR) for aortic pathologies requires sufficient landing zone of ideally more than 25 mm for safe anchoring of the stent-graft and prevention of endoleaks. In the aortic arch and at the thoracoabdominal transition, landing zone length is usually limited by the offspring of the major aortic side-branches. Exact deployment of the stent-graft to effectively use the whole length of the landing zone and to prevent occlusion of one of the side-branches is key to successful TEVAR. There are numerous techniques described to lower blood pressure and to reduce or eliminate aortic impulse to facilitate exact deployment of stent-grafts including pharmacologic blood pressure lowering, adenosine-induced asystole, inflow occlusion, and rapid pacing. Aim of this review was to assess the current literature to identify which of the techniques is best suited to prevent displacement and allow for precise placement of the stent-graft and safe balloon-molding.
Implementation of Perioperative Point-of-Care Platelet Function Analyses Reduces Transfusion Requirements in Cardiac Surgery: A Retrospective Cohort Study
Authors: Wang Lihui , Valencia Oswaldo , Phillips Simon , Sharma Vivek 
Published: June 2020

Abstract
Background Platelet dysfunction is a common cause of bleeding, perioperative blood transfusion, and surgical re-exploration in cardiac surgical patients. We evaluated the effect of incorporating a platelet function analyzer utilizing impedance aggregometry (Multiplate, Roche, Munich, Germany) into our local transfusion algorithm on the rate of platelet transfusion and postoperative blood loss in patients undergoing coronary artery bypass grafting (CABG) surgery.
Methods Data were collected on patients undergoing CABG surgery from January 2015 to April 2017. Patients who underwent surgery before and after introduction of this algorithm were classified into prealgorithm and postalgorithm groups, respectively. The primary outcome was the rate of platelet transfusion before and after implementation of the Multiplate-based transfusion algorithm. Secondary outcomes included transfusion rate of packed red blood cells, postoperative blood loss at 12 and 24 hours, length of stay in the intensive care unit, and the hospital and mortality.
Results A total of 726 patients were included in this analysis with 360 and 366 patients in the pre- and postalgorithm groups, respectively. Transfusion rates of platelets (p = 0.01) and packed red blood cells (p = 0.0004) were significantly lower following introduction of the algorithm in patients (n = 257) who had insufficient time to withhold antiplatelet agents. Receiver operating characteristic curves defined optimal cutoff points of arachidonic acid and adenosine diphosphate assays on the Multiplate to predict future platelet transfusion were 23AU and 43AU, respectively.
Conclusions The introduction of a Multiplate-based platelet transfusion algorithm showed a statistically significant reduction in the administration of platelets to patients undergoing urgent CABG surgery.
Cementless Tritanium Baseplate Total Knee Arthroplasty: Survivorship and Outcomes at 5-Year Minimum Follow-Up
Authors: Tarazi John M. , Salem Hytham S. , Ehiorobo Joseph O. , Sodhi Nipun , Mont Michael A. , Harwin Steven F. 
Published: June 2020

Abstract
Background Newer generation cementless total knee arthroplasty (TKA) designs have provided stronger osteointegration between the implant and bone. Despite excellent survivorship and outcomes with cemented TKAs, areas of concern within the bone–cement interface remain a concern and necessitate studies on alternative constructs. This study assesses: (1) implant survivorship; (2) clinical outcomes; and (3) complications with radiographic outcomes at a 5-year minimum follow-up of cementless highly porous titanium-coated baseplates in TKAs.
Methods Part of this study has been reported. We retrospectively reviewed a prospectively collected database at a single high-volume institution between July 1, 2013 and June 30, 2014 for patients who underwent a primary TKA using cementless highly porous titanium-coated baseplate implants. Patients were evaluated clinically at postoperative follow-up visits at a minimum of 5 years. To calculate the survivorship, Kaplan–Meier analysis was performed to determine all-cause, aseptic, and septic implant survivorship at each final follow-up for all patients.
Results A total of 228 TKAs were performed and followed for a minimum of 5 years (range, 5–6 years). As of the latest follow-up, one case of septic loosening of the patellar button and one case of patellar dislodgment secondary to physical manipulation were recorded and revised. Overall, the cohort displayed implant survivorship of 99.5% at 5-year minimum follow-up. Improvements were seen in both Knee Society pain and function scores and were 37 points (range, 17–60 points) and 28 points (range, 15–47 points), respectively. The mean improvement in flexion was 17.8 (range, –20 to 40 degrees) and mean improvement in extension was –5.5 (range, –30 to 5 degrees).
Discussion Cementless TKAs serve as strong alternative choice to cemented TKAs. Although cemented fixation is commonly known as the gold standard, results of this study confirm the findings of previous investigations on the survivorship of cementless TKA implants. Therefore, patients who undergo primary TKA with a cementless tritanium baseplate can expect excellent clinical outcomes at a 5-year minimum follow-up.
Successful Management of an Infant with Atypical Presentation of Alveolar Capillary Dysplasia with Misalignment of the Pulmonary Veins
Authors: Neuhäuser Christoph Armin , Kreymborg Karsten Grosse , Müller Carsten , Khalil Markus , Jux Christian , Galambos Csaba , Schranz Dietmar 
Published: June 2020

AbstractA newborn infant patient presented with persistent pulmonary hypertension. For right ventricular decompression, the ductus arteriosus was kept open by prostaglandin E1 infusion and was stented at the age of 4 weeks during heart catheterization. The child was weaned from mechanical ventilation, since pulmonary functions were adequate. A small atrial septal defect was identified and closed in cardiac catheterization laboratory to decrease preductal hypoxemia. Diagnostic workup led to the diagnosis of alveolar capillary dysplasia with misalignment of the pulmonary veins. Suprasystemic pulmonary arterial hypertension with persisting nitric oxide dependency remained the leading symptoms. The child underwent bilateral lung transplantation at the age of 28 months. He is well at the age of 44 months.
Knowledge transfer into sport practice: An empirical user analysis of a sport science website
Authors: Sperlich Billy , Wicker Pamela 
Published: June 2020

AbstractTransferring scientific knowledge to applied practitioners presents a challenge in sport science. Knowledge transfer, conceptualized as knowledge reuse and knowledge contribution, has mainly been studied in the context of specific topics, projects, or organizations. The purposes of this study were to investigate the determinants of knowledge transfer from a publicly available website to its users and to cluster users into different groups based on their level of knowledge transfer. The website www.sportsandscience.de is dedicated to translating evidence‐based knowledge that is regularly generated in scientific studies into short and digestible information through e.g. videos and blogs, and provides opportunities for knowledge reuse and contribution. A theoretical model of knowledge transfer in organizations which was adapted to this context guided the study. Data from an online survey of registered website users were employed for the empirical analysis. The regression analyses showed that knowledge reuse is positively affected by ease of knowledge access and negatively by age. Knowledge reuse, job experience, and male gender have a significant positive effect on knowledge contribution. The findings suggest that the theoretical model is generally applicable to this context, but also highlight differences to the original organizational setting. Cluster analysis yielded three clusters: Frequent users, occasional users, and frequent contributors. Analyses of variances revealed significant differences among clusters regarding computer self‐efficacy, job experience, gender, age, employment, interested sports, and conditional skills, but not concerning education and formal qualifications. Implications for improving knowledge transfer of such a website are provided.
Deconstructing effective non-Hermitian dynamics in quadratic bosonic Hamiltonians
Authors: Flynn Vincent P , Cobanera Emilio , Viola Lorenza 
Published: June 2020

Abstract
Unlike their fermionic counterparts, the dynamics of Hermitian quadratic bosonic Hamiltonians are governed by a generally non-Hermitian Bogoliubov-de Gennes effective Hamiltonian. This underlying non-Hermiticity gives rise to a dynamically stable regime, whereby all observables undergo bounded evolution in time, and a dynamically unstable one, whereby evolution is unbounded for at least some observables. We show that stability-to-instability transitions may be classified in terms of a suitably generalized

P
T

symmetry, which can be broken when diagonalizability is lost at exceptional points in parameter space, but also when degenerate real eigenvalues split off the real axis while the system remains diagonalizable. By leveraging tools from Krein stability theory in indefinite inner-product spaces, we introduce an indicator of stability phase transitions, which naturally extends the notion of phase rigidity from non-Hermitian quantum mechanics to the bosonic setting. As a paradigmatic example, we fully characterize the stability phase diagram of a bosonic analogue to the Kitaev–Majorana chain under a wide class of boundary conditions. In particular, we establish a connection between phase-dependent transport properties and the onset of instability, and argue that stable regions in parameter space become of measure zero in the thermodynamic limit. Our analysis also reveals that boundary conditions that support Majorana zero modes in the fermionic Kitaev chain are precisely the same that support stability in the bosonic chain.
The dynamics of cooperation in asymmetric sub-populations
Authors: Guo H , Li X , Hu K , Dai X , Jia D , Boccaletti S , Perc M , Wang Z 
Published: June 2020

Abstract
Sacrificing personal benefits for a common good is at odds with the fundamental principle of Darwinian evolution: if only the fittest survives, then there should be no place for cooperation. But cooperative behavior actually abounds, and constitutes one of the most persistent and fascinating puzzles of nature. One solution to this puzzle is network reciprocity, where the collective dynamics of cooperators affords them protection against invading defectors. Commonly, however, such a competition does not unfold in isolation. Populations are often divided into sub-populations, with different evolutionary rules describing the interactions between them. Here we propose and study a paradigmatic model that captures the essence of this setup. Specifically, if two players belong to the same sub-population, they play the prisoner’s dilemma game. If not, they play either the harmony game, the snowdrift game, the stag-hunt game, or the prisoner’s dilemma game. Due to such an asymmetry in the interactions across sub-populations, a fascinating evolutionary dynamics sets up that greatly expands the survivability of cooperators. For instance, when the harmony game applies, cyclic dominance spontaneously emerges, wherein cooperators in one sub-population become predators of defectors in the other sub-population. One also may observe self-organized segregation, wherein both sub-populations maintain a mixed state of cooperators and defectors. As a general rule, we show that the lower the dilemma strength between sub-populations, the more abundant the cooperative strategy in the entire population. Results are confirmed by means of Monte Carlo simulations with pair approximation method, which reveals a rich plethora of novel and generally valid paths to cooperation.
Nanosized Iron Oxyhydroxide: Properties, Application, Preparation
Authors: Abuzarova Kamila , Korchuganova Olena 
Published: June 2020

Abstract
Nanoparticles are increasingly in demand in such rapidly developing types of human activity as microelectronics, catalysis, biosensors, etc. The mild neutralization process is desirable to obtain a high-quality product due to forming a great amount of nucleation centers. The advantage of carbamide application is its capability to dissolve in the reaction volume without interacting with it, and evenly distribute in volume, slowly hydrolyzing with ammonium ions formation. At the same time, a very mild neutralization regime is realized without local pH value excess. Method of iron oxyhydroxide obtaining by carbamide precipitation is illustrated below. The aim of investigation was to obtain nanoscale precipitate, to study the properties of the obtained material and to describe the precipitation process. The study of the iron (III) oxyhydroxide precipitation kinetics from the iron (III) sulphate solution, and a mathematical model of the process are presented in the article. A mathematical model of the precipitation process allows to take into account the influence of the substances concentration and the process temperature to the rate of precipitate production. The precipitate was characterized by X-ray and DTA analysis, as well as by Raman spectroscopy and scanning electron microscopy methods.
Supercapacitors as elements increasing the efficiency of photovoltaic installation
Authors: Rogowski Sz , Sibński M , Kolczyńska A , Kluba A 
Published: June 2020

Abstract
The main purpose of the research is to check an influence of supercapacitors as the elements increasing the efficiency of short-period energy storage in photovoltaic installations. Their task will be to substitute the batteries or enhance their performance as the energy bank. For the model storage setup consisting of six supercapacitors, the work charge-discharge characteristics were determined. Additionally, an influence of storage time on the amount of charge accumulated inside the battery was tested. Then the examined setup was coupled with a conventional PV module by the charge regulator system and tested in laboratory and under real operating conditions. Obtained results proved that the use of supercapacitors as buffer elements in energy storage system of photovoltaic installation can significantly increase operation lifetime and reliability.
Application of the local antimagic total labeling of graphs to optimise scheduling system for an expatriate assignment
Authors: Utami W , Wijaya K , Slamin  
Published: June 2020

Abstract
An expatriate assignment at the branch company in other country must be optimised due to the short term duty. Accuracy calculation is needed to optimise the expatriate assignment including its scheduling system. There are many ways and methods to optimise the scheduling system. One of the methods is making use of graph theory instruments such as local antimagic total labeling. The local antimagic total labeling of a graph is a map from the set of vertices and edges of the graph to the set of positive integers from 1 to the number of vertices and edges such that the weight of two adjacent vertices are different. The vertex weight is calculated by adding the labels of the vertex and all edges incident to it. In this paper, this labeling is applied to optimise the scheduling system for the expatriate assignment. This system can be modelled by a graph where the assignments are represented by vertices and connection between the assignments are represented by edges. The represented graph is then labelled by the local antimagic total labeling in order to obtain the minimum number of different vertex weights. The such number is equivalent to the optimal time allocated for the expatriate assignment.