bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability Analysis of Alternating Group Graphs and Split-Stars
Authors: Gu Mei-Mei , Hao Rong-Xia , Chang Jou-Ming 
Published: June 2020

AbstractGiven a connected graph $G$ and a positive integer $\ell $, the $\ell $-extra (resp. $\ell $-component) edge connectivity of $G$, denoted by $\lambda ^{(\ell )}(G)$ (resp. $\lambda _{\ell }(G)$), is the minimum number of edges whose removal from $G$ results in a disconnected graph so that every component has more than $\ell $ vertices (resp. so that it contains at least $\ell $ components). This naturally generalizes the classical edge connectivity of graphs defined in term of the minimum edge cut. In this paper, we proposed a general approach to derive component (resp. extra) edge connectivity for a connected graph $G$. For a connected graph $G$, let $S$ be a vertex subset of $G$ for $G\in \{\Gamma _{n}(\Delta ),AG_n,S_n^2\}$ such that $|S|=s\leq |V(G)|/2$, $G[S]$ is connected and $|E(S,G-S)|=\min \limits _{U\subseteq V(G)}\{|E(U, G-U)|: |U|=s, G[U]\ \textrm{is connected}\ \}$, then we prove that $\lambda ^{(s-1)}(G)=|E(S,G-S)|$ and $\lambda _{s+1}(G)=|E(S,G-S)|+|E(G[S])|$ for $s=3,4,5$. By exploring the reliability analysis of $AG_n$ and $S_n^2$ based on extra (component) edge faults, we obtain the following results: (i) $\lambda _3(AG_n)-1=\lambda ^{(1)}(AG_n)=4n-10$, $\lambda _4(AG_n)-3=\lambda ^{(2)}(AG_n)=6n-18$ and $\lambda _5(AG_n)-4=\lambda ^{(3)}(AG_n)=8n-24$; (ii) $\lambda _3(S_n^2)-1=\lambda ^{(1)}(S_n^2)=4n-8$, $\lambda _4(S_n^2)-3=\lambda ^{(2)}(S_n^2)=6n-15$ and $\lambda _5(S_n^2)-4=\lambda ^{(3)}(S_n^2)=8n-20$. This general approach maybe applied to many diverse networks.
Rethinking the Ethnography of Communication's Conception of Value in the Context of Globalization
Authors: Boromisza-Habashi David , Fang Yaqiong 
Published: June 2020

AbstractAs a key approach to the study of language and social interaction within the field of communication, the ethnography of communication (EC) posits that speech communities value communication resources for their functions in the process of competent use. We argue that this conception of value creates theoretical blind spots for other types of value that derive from other processes besides competent use, such as the exchange and acquisition of communication resources. Drawing on recent anthropological scholarship and our own cross-cultural comparative case study of United States and Chinese students' accounts of learning Anglo-American public speaking, we claim that, from an ethnographic perspective, a communication resource has value insofar as speakers interpret it as an object of desire due to its function as a means to other valued entities or focal values in the context of relevant social processes.
Screening for cardiovascular disease risk using traditional risk factor assessment or coronary artery calcium scoring: the ROBINSCA trial
Authors: van der Aalst Carlijn M , Denissen Sabine J A M , Vonder Marleen , Gratama Jan Willem C , Adriaansen Henk J , Kuijpers Dirkjan , Vliegenthart Rozemarijn , van Lennep Jeanine E Roeters , van der Harst Pim , Braam Richard L , van Dijkman Paul R M , van Bruggen Rykel , Oudkerk Matthijs , de Koning Harry J 
Published: June 2020

Abstract

Aims
Screening for a high cardiovascular disease (CVD) risk followed by preventive treatment can potentially reduce coronary heart disease-related morbidity and mortality. ROBINSCA (Risk Or Benefit IN Screening for CArdiovascular disease) is a population-based randomized controlled screening trial that investigates the effectiveness of CVD screening in asymptomatic participants using the Systematic COronary Risk Evaluation (SCORE) model or coronary artery calcium (CAC) scoring. This study describes the distributions in risk and treatment in the ROBINSCA trial.

Methods and results
Individuals at expected elevated CVD risk were randomized into screening arm A (n = 14 478; SCORE, 10-year fatal and non-fatal risk); or screening arm B (n = 14 450; CAC scoring). Preventive treatment was largely advised according to current Dutch guidelines. Risk and treatment differences between the screening arms were analysed. A total of 12 185 participants (84.2%) in arm A and 12 950 (89.6%) in arm B were screened. In total, 48.7% were women, and median age was 62 (interquartile range 10) years. SCORE screening identified 45.1% at low risk (SCORE &lt; 10%), 26.5% at intermediate risk (SCORE 10–20%), and 28.4% at high risk (SCORE ≥ 20%). According to CAC screening, 76.0% were at low risk (Agatston &lt; 100), 15.1% at high risk (Agatston 100–399), and 8.9% at very high risk (Agatston ≥ 400). CAC scoring significantly reduced the number of individuals indicated for preventive treatment compared to SCORE (relative reduction women: 37.2%; men: 28.8%).

Conclusion
We showed that compared to risk stratification based on SCORE, CAC scoring classified significantly fewer men and women at increased risk, and less preventive treatment was indicated.

Trial registration number
NTR6471.
On Theorizing International Organizations Law: Editors’ Introduction
Authors: Klabbers Jan , Sinclair Guy Fiti 
Published: June 2020

Abstract
This short article introduces a symposium on the intellectual history of international organizations law, which focuses on the contributions of six international lawyers: Henry G. (Hein) Schermers, Clarence Wilfred Jenks, Paul Reuter, Louis Sohn, Georges Abi-Saab and Hans Kelsen.
Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy
Authors: Viereck Janika , Bührke Anne , Foinquinos Ariana , Chatterjee Shambhabi , Kleeberger Jan A , Xiao Ke , Janssen-Peters Heike , Batkai Sandor , Ramanujam Deepak , Kraft Theresia , Cebotari Serghei , Gueler Faikah , Beyer Andreas M , Schmitz Jessica , Bräsen Jan H , Schmitto Jan D , Gyöngyösi Mariann , Löser Alexandra , Hirt Marc N , Eschenhagen Thomas , Engelhardt Stefan , Bär Christian , Thum Thomas 
Published: June 2020

Abstract

Aims
Pathological cardiac remodelling and subsequent heart failure represents an unmet clinical need. Long non-coding RNAs (lncRNAs) are emerging as crucial molecular orchestrators of disease processes, including that of heart diseases. Here, we report on the powerful therapeutic potential of the conserved lncRNA H19 in the treatment of pathological cardiac hypertrophy.

Method and results
Pressure overload-induced left ventricular cardiac remodelling revealed an up-regulation of H19 in the early phase but strong sustained repression upon reaching the decompensated phase of heart failure. The translational potential of H19 is highlighted by its repression in a large animal (pig) model of left ventricular hypertrophy, in diseased human heart samples, in human stem cell-derived cardiomyocytes and in human engineered heart tissue in response to afterload enhancement. Pressure overload-induced cardiac hypertrophy in H19 knock-out mice was aggravated compared to wild-type mice. In contrast, vector-based, cardiomyocyte-directed gene therapy using murine and human H19 strongly attenuated heart failure even when cardiac hypertrophy was already established. Mechanistically, using microarray, gene set enrichment analyses and Chromatin ImmunoPrecipitation DNA-Sequencing, we identified a link between H19 and pro-hypertrophic nuclear factor of activated T cells (NFAT) signalling. H19 physically interacts with the polycomb repressive complex 2 to suppress H3K27 tri-methylation of the anti-hypertrophic Tescalcin locus which in turn leads to reduced NFAT expression and activity.

Conclusion
H19 is highly conserved and down-regulated in failing hearts from mice, pigs and humans. H19 gene therapy prevents and reverses experimental pressure-overload-induced heart failure. H19 acts as an anti-hypertrophic lncRNA and represents a promising therapeutic target to combat pathological cardiac remodelling.
Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance
Authors: Li Qing-Hai , Wang Ying-Zhao , Tu Jian , Liu Chu-Wei , Yuan Yu-Jie , Lin Run , He Wei-Ling , Cai Shi-Rong , He Yu-Long , Ye Jin-Ning 
Published: June 2020

AbstractCetuximab and panitumumab, as the highly effective antibodies targeting epidermal growth factor receptor (EGFR), have clinical activity in the patients with metastatic colorectal cancer (mCRC). These agents have good curative efficacy, but drug resistance also exists at the same time. The effects of KRAS, NRAS, and BRAF mutations and HER2 amplification on the treatment of refractory mCRC have been elucidated and the corresponding countermeasures have been put forward. However, the changes in EGFR and its ligands, the mutations or amplifications of PIK3CA, PTEN, TP53, MET, HER3, IRS2, FGFR1, and MAP2K1, the overexpression of insulin growth factor-1, the low expression of Bcl-2-interacting mediator of cell death, mismatch repair-deficient, and epigenetic instability may also lead to drug resistance in mCRC. Although the emergence of drug resistance has genetic or epigenetic heterogeneity, most of these molecular changes relating to it are focused on the key signaling pathways, such as the RAS/RAF/mitogen-activated protein kinase or phosphatidylinositol 3-kinase/Akt/mammalian target of the rapamycin pathway. Accordingly, numerous efforts to target these signaling pathways and develop the novel therapeutic regimens have been carried out. Herein, we have reviewed the underlying mechanisms of the resistance to anti-EGFR therapy and the possible implications in clinical practice.
State Power and ‘Everyday Criminality’ in the German Democratic Republic, 1961–1989
Authors: Millington Richard 
Published: June 2020

Abstract
Friedrich Engels claimed that the removal of the perceived causes of crime in a society—capitalist economic and societal conditions—would automatically lead to the eradication of crime. This did not prove to be the case in the German Democratic Republic (GDR), where instances of everyday criminality such as theft, robbery and assault never fell below 100,000 per annum throughout the period of the state’s existence, from 1949 to 1989. This article examines the ruling Socialist Unity Party’s (SED) perceptions of the causes of everyday criminality in the GDR. It shows that the SED concluded that crime persisted because citizens’ ‘socialist sense of legal right and wrong’ (sozialistisches Rechtsbewußtsein) was underdeveloped. The regime measured this by the extent to which citizens supported and participated in socialist society. Thus, crime could be eliminated by co-opting as many citizens as possible into the Party’s political project. The SED’s ideological tunnel vision on the causes of everyday criminality meant that it dismissed hints about the real causes of crime, such as poor supply and living conditions, identified by its analysts. Its failure to address these issues meant that citizens continued to break the law. Thus, the Party’s exercise of power contributed to the creation of limits to that power. Moreover, analysis of opinion polls on GDR citizens’ attitudes to criminality shows that they accepted crime as a part of everyday life.
The Importance of a Filament-like Structure in Aerial Dispersal and the Rarefaction Effect of Air Molecules on a Nanoscale Fiber: Detailed Physics in Spiders’ Ballooning
Authors: Cho Moonsung , Koref Iván Santibáñez 
Published: June 2020

SynopsisMany flying insects utilize a membranous structure for flight, which is known as a “wing.” However, some spiders use silk fibers for their aerial dispersal. It is well known that spiders can disperse over hundreds of kilometers and rise several kilometers above the ground in this way. However, little is known about the ballooning mechanisms of spiders, owing to the lack of quantitative data. Recently, Cho et al. discovered previously unknown information on the types and physical properties of spiders’ ballooning silks. According to the data, a crab spider weighing 20 mg spins 50–60 ballooning silks simultaneously, which are about 200 nm thick and 3.22 m long for their flight. Based on these physical dimensions of ballooning silks, the significance of these filament-like structures is explained by a theoretical analysis reviewing the fluid-dynamics of an anisotropic particle (like a filament or a high-slender body). (1) The filament-like structure is materially efficient geometry to produce (or harvest, in the case of passive flight) fluid-dynamic force in a low Reynolds number flow regime. (2) Multiple nanoscale fibers are the result of the physical characteristics of a thin fiber, the drag of which is proportional to its length but not to its diameter. Because of this nonlinear characteristic of a fiber, spinning multiple thin ballooning fibers is, for spiders, a better way to produce drag forces than spinning a single thick spider silk, because spiders can maximize their drag on the ballooning fibers using the same amount of silk dope. (3) The mean thickness of fibers, 200 nm, is constrained by the mechanical strength of the ballooning fibers and the rarefaction effect of air molecules on a nanoscale fiber, because the slip condition on a fiber could predominate if the thickness of the fiber becomes thinner than 100 nm.
Invariants of a General Branched Cover of P1
Authors: Bujokas Gabriel , Patel Anand 
Published: June 2020

Abstract
We investigate the resolution of a general branched cover $\alpha \colon C \to \mathbf{P}^1$ in its relative canonical embedding $C \subset \mathbf{P} E$. We conjecture that the syzygy bundles appearing in the resolution are balanced for a general cover, provided that the genus is sufficiently large compared to the degree. We prove this for the Casnati–Ekedahl bundle, or bundle of quadrics $F$—the 1st bundle appearing in the resolution of the ideal of the relative canonical embedding. Furthermore, we prove the conjecture for all syzygy bundles in the resolution when the genus satisfies $g = 1 \mod d$.
On the Statistical Testing Methods for Single Laboratory Validation of Qualitative Microbiological Assays with a Paired Design
Authors: Wang Shizhen S 
Published: June 2020

Abstract

Background
There are several statistical methods for detecting a difference of detection rates between alternative and reference qualitative microbiological assays in a single laboratory validation study with a paired design.

Objective
We compared performance of eight methods including McNemar’s test, sign test, Wilcoxon signed-rank test, paired t-test, and the regression methods based on conditional logistic (CLOGIT), mixed effects complementary log-log (MCLOGLOG), mixed effects logistic (MLOGIT) models, and a linear mixed effects model (LMM).

Methods
We first compared the minimum detectable difference in the proportion of detections between the alternative and reference detection methods among these statistical methods for a varied number of test portions. We then compared power and type 1 error rates of these methods using simulated data.

Results
The MCLOGLOG and MLOGIT models had the lowest minimum detectable difference, followed by the LMM and paired t-test. The MCLOGLOG and MLOGIT models had the highest average power but were anticonservative when correlation between the pairs of outcome values of the alternative and reference methods was high. The LMM and paired t-test had mostly the highest average power when the correlation was low and the second highest average power when the correlation was high. Type 1 error rates of these last two methods approached the nominal value of significance level when the number of test portions was moderately large (n &gt; 20).

Highlights
The LMM and paired t-test are better choices than other competing methods, and we provide an example using real data.
Should Denmark and Sweden Join the Banking Union?
Authors: Hougaard Jensen Svend E , Schoenmaker Dirk 
Published: June 2020

Abstract
An important policy discussion on joining the banking union is currently taking place in Denmark and Sweden. In this article we review the pros and cons of joining. The main rationale for joining the banking union is the importance of cross-border banking in the EU internal market. Reviewing the banking systems, we find that banks in Denmark and Sweden have the same cross-border characteristics as those in the euro area countries, suggesting a similar rationale for joining the banking union. Moreover, both countries have large banks which may be too big to save at country level, but not at the banking union level. Nevertheless, there are some governance concerns. While euro area countries have an automatic and full say in all banking union arrangements, the non-euro area countries (the ‘out’ countries) lack certain formal powers in ultimate decision-making; however, we find that this may be less of a problem in practice. If necessary, the ‘out’ countries would have the ‘nuclear option’ of leaving the banking union.
Systematic Review and STARD Scoring of Renal Cell Carcinoma Circulating Diagnostic Biomarker Manuscripts
Authors: Iafolla Marco A J , Picardo Sarah , Aung Kyaw , Hansen Aaron R 
Published: June 2020

Abstract

Background
No validated molecular biomarkers exist to help guide diagnosis of renal cell carcinoma (RCC) patients. We seek to evaluate the quality of published RCC circulating diagnostic biomarker manuscripts using the Standards for Reporting of Diagnostic Accuracy Studies (STARD) guidelines.

Methods
The phrase “(renal cell carcinoma OR renal cancer OR kidney cancer OR kidney carcinoma) AND circulating AND (biomarkers OR cell free DNA OR tumor DNA OR methylated cell free DNA OR methylated tumor DNA)” was searched in Embase, MEDLINE, and PubMed in March 2018. Relevant manuscripts were scored using 41 STARD subcriteria for a maximal score of 26 points. All tests of statistical significance were 2 sided.

Results
The search identified 535 publications: 27 manuscripts of primary research were analyzed. The median STARD score was 11.5 (range = 7-16.75). All manuscripts had appropriate abstracts, introductions, and distribution of alternative diagnoses. None of the manuscripts stated how indeterminant data were handled or if adverse events occurred from performing the index test or reference standard. Statistically significantly higher STARD scores were present in manuscripts reporting receiver operator characteristic curves (P &lt; .001), larger sample sizes (P = .007), and after release of the original STARD statement (P = .005).

Conclusions
Most RCC circulating diagnostic biomarker manuscripts poorly adhere to the STARD guidelines. Future studies adhering to STARD guidelines may address this unmet need.
Logic fluidity: How frontline professionals use institutional logics in their day-to-day work
Authors: ten Dam Eline M , Waardenburg Maikel 
Published: June 2020

AbstractThis article aims to gain a better understanding on micro processes of how frontline professionals use institutional logics in their day-to-day work. It contributes to the growing literature on the dynamics between institutions and the professional frontline. To further develop this field of study, a conceptual framework is presented that integrates institutional logics, vocabularies of practice, and narratives as central concepts. By adopting a composite narrative approach and identifying vocabularies of practice, the article interprets how frontline professionals make use of different logics to make sense of a new principle introduced in their professional field. Findings are based on a case study of professional patient collaboration in healthcare. The article composes five narratives that act as vehicles through which healthcare professionals use five logics: a medical professional logic, managerial logic, commercial logic, consultation logic, and patient-centeredness logic. It argues that frontline professionals use vocabularies of practice to assemble narratives that help them to navigate between a plurality of logics. It further shows that professionals move fluently from one narrative to another, critiquing the ideas of adherence to a dominant logic and conflict solving. The article finalizes with a discussion that advocates for a process studies perspective and a stronger focus on micro processes in research on professional performance in the context of institutional plurality.
Modelling time variations of root diameter and elongation rate as related to assimilate supply and demand
Authors: Pagès Loïc , Bernert Marie , Pagès Guillaume 
Published: June 2020

Abstract
In a given root system, individual roots usually exhibit a rather homogeneous tip structure although highly different diameters and growth patterns, and this diversity is of prime importance in the definition of the whole root system architecture and foraging characteristics. In order to represent and predict this diversity, we built a simple and generic model at root tip level combining structural and functional knowledge on root elongation. The tip diameter, reflecting meristem size, is used as a driving variable of elongation. It varies, in response to the fluctuations of photo-assimilate availability, between two limits (minimal and maximal diameter). The elongation rate is assumed to be dependent on the transient value of the diameter. Elongation stops when the tip reaches the minimal diameter. The model could satisfactorily reproduce patterns of root elongation and tip diameter changes observed in various species at different scales. Although continuous, the model could generate divergent root classes as classically observed within populations of lateral roots. This model should help interpret the large plasticity of root elongation patterns which can be obtained in response to different combinations of endogenous and exogenous factors. The parameters could be used in phenotyping the root system.
The radio-loud narrow-line Seyfert 1 galaxy 1H 0323+342 in a galaxy merger
Authors: Doi Akihiro , Kino Motoki , Kawakatu Nozomu , Hada Kazuhiro 
Published: June 2020

ABSTRACT
The supermassive black holes (SMBHs) of narrow-line Seyfert 1 galaxies (NLS1s) are at the lower end of the mass function of active galactic nuclei (AGNs) and reside preferentially in late-type host galaxies with pseudobulges, which are thought to be formed by internal secular evolution. On the other hand, the population of radio-loud NLS1s presents a challenge for the relativistic jet paradigm, which states that powerful radio jets are associated exclusively with very high mass SMBHs in elliptical hosts, which are built up through galaxy mergers. We investigated distorted radio structures associated with the nearest gamma-ray-emitting, radio-loud NLS1, 1H 0323+342. This provides supporting evidence for the merger hypothesis based on past optical/near-infrared observations of its host galaxy. The anomalous radio morphology consists of two different structures: the inner curved structure of the currently active jet and an outer linear structure of low-brightness relics. Such coexistence might be indicative of the stage of an established black hole binary with precession before the black holes coalesce in the galaxy merger process. 1H 0323+342 and other radio-loud NLS1s under galaxy interactions may be extreme objects on the evolutionary path from radio-quiet NLS1s to normal Seyfert galaxies with larger SMBHs in classical bulges through mergers and merger-induced jet phases.