bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Approaches and Management of Subacute Sclerosing Panencephalitis in Children
Authors: Hidayah Nurul , Wijaya Andreas Budi 
Published: October 2020

Abstract: Subacute Sclerosing Panencephalitis (SSPE) is a progressive neurodegenerative disease that attacks the central nervous system, especially in the population of children and early adolescents, due to persistent measles virus infection. The incidence of SSPE is quite rare, and data shows that in developing countries it is still quite high compared to developed countries. Diagnosis is based on clinical, supporting examinations such as EEG, as well as increased antibodies against measles virus in serum and cerebrospinal fluid. Symptoms can include changes in behavior, myoclonus, memory problems, and persistent pyramidal or extrapyramidal movements. Management to date has not provided satisfactory results and is individualized. Most SSPE patients experience a progressive and gradual course, leading to death within 1-3 years. The challenge of SSPE in children is the approach to diagnosis and management. Until now, the approach to treating SSPE in children is still based on the pathophysiological mechanisms from several existing research studies. That why therapy guidelines for children with SSPE are still varied. This paper aims to discuss the topic of SSPE in children with a major focus on diagnostic and therapeutic approaches based on the latest scientific evidence. Keywords: Subacute Sclerosing Panencephalitis (SSPE), children, diagnosis, therapy
Identifikasi dan Deskripsi Tanaman Umbi-Umbian Pengganti Karbohidrat di Kabupaten Trenggalek
Authors: Latifah Evy , Prahardini PER 
Published: October 2020

<p>The programs to increased food diversification through policies to accelerate diversification of food consumption based on local resources as a substitute for rice. The tubers that have been widely used by the community are cassava, sweet potato and potato. However, there are still many other yam plants that have not been maximally utilized and developed<strong>. </strong>Thus it is necessary to carry out research aimed at knowing the identification and description of tuber crops, especially in several sub-districts in Trenggalek Regency. The determination of the research area was carried out by using purposive sampling method by coordinating with the Trenggalek Regency Agriculture Office, then to obtain data on the potential area of tubers was carried out by sampling using the snowball sampling method. From the results of the study, it is known that Munjungan sub-district is one of the districts that has the most land area (154.80 km2) compared to other sub-districts in Trenggalek Regency so that it is able to produce the production of several tuber commodities including uwi, gembili, gadung, suweg and bentoel so it needs development for this tubers in the region.<strong></strong></p>
The Effect of Organizational Culture, Leadership Style, and Trust to Organizational Commitments of LP3I Polytechnic Jakarta Lectures
Authors: Hamonangan Ismail Dingot , Asmawi Moch. , Widodo Suparno Eko 
Published: October 2020

The purpose of this study is to obtain valid and reliable empirical data, facts and information about the influence of organizational culture, leadership style, and trust to the organizational commitment of the LP3I Polytechnic Lecturers in Jakarta. This study makes the use of associative quantitative approach and path analysis technique. The population in this study were all permanent lecturers at the LP3I Polytechnic Jakarta with 215 people in total. The sampling method was using simple random sampling upon all permanent lecturers at the LP3I Polytechnic Jakarta who were actively working in 2017. The sample was taken using the Slovin formula and the sample size therefore was 145 lecturers. The research data was filtered through questionnaires. The results of the study concluded that there was a positive direct effect of Organizational Culture to the Organizational Commitment, there was a positive direct effect of Leadership Style to Organizational Commitment, there was a positive direct influence Trust to Organizational Commitment, there was a positive direct influence Organizational Culture to Trust, there was a positive direct influence Leadership Style to Trust , there was a positive influence of Organizational Culture, Leadership Style and trust simultaneously to Organizational Commitment and there was a positive influence of Organizational Culture and Leadership Style simultaneously to the trustworthiness of the LP3I Polytechnic Lecturers in Jakarta. This finding implied that, should you want to increase the Commitment of LP3I Polytechnic Jakarta Lecturers to the organization, it can be done through the increase of Organizational Culture, Leadership and Trust Style in a systematic and planned manner.
Cement-In-Cement All-Polyethylene Tibial Revision
Authors: Gausden Elizabeth B. , Sierra Rafael J. 
Published: October 2020

Case:
Debonding of the tibial component of total knee arthroplasty is a known complication that is typically treated with revision surgery, most commonly revision to a metal-backed tibial component with or without stems. Here, we present 3 cases of tibial component debonding revised to all-polyethylene tibial components with a cement-in-cement technique.

Conclusion:
In instances of tibial component debonding, if specific criteria are met, revising to an all-polyethylene tibia with retention of the primary cement mantle is an alternative to revision surgery with cement extraction and implantation of a modular metal-backed tibia.
The Veiled Women Self-Adjusment
Authors: Kusumawati Sofia Panca , Hazim Hazim 
Published: October 2020

This research aims to find out forms of self-adjustment and factors which underlie the using of veil (cadar). This research uses qualitative method. The research informants in this study are three adult women who are domiciled in Sidoarjo. Determination of the research informants is done by using random sampling. Then, structured interview method is used to collect the data in this research. The result of this research shows that three of informants can perform self-adjustment positively. The positive forms of self-adjustment are be able to face problems directly, be able to solve the problems, be able to do substance (looking for a replacement), be able to understand self-potential, be able to apply learning experience, and be able to act realistic attitude. All of these are supported by the changes of personality and attitude from three informants who grow up more mature and wiser in facing their problems.
Pi-starvation induced transcriptional changes in barley revealed by a comprehensive RNA-Seq and degradome analyses
Authors: Sega Pawel , Kruszka Katarzyna , Bielewicz Dawid , Karlowski Wojciech , Nuc Przemyslaw , Szweykowska-Kulinska Zofia , Pacak Andrzej 
Published: September 2020

Abstract
Background: Small RNAs (sRNAs) are 20–30 nt regulatory elements which are responsible for plant development regulation and participate in many plant stress responses. Insufficient inorganic phosphate (Pi) concentration triggers plant responses to balance the internal Pi level. Results: In this study, we describe Pi-starvation-responsive small RNAs and transcriptome changes in barley (Hordeum vulgare L.) using Next-Generation Sequencing (NGS) RNA-Seq data derived from three different types of NGS libraries: (i) small RNAs, (ii) degraded RNAs, and (iii) functional mRNAs. We find that differentially and significantly expressed miRNAs (DEMs, p-value < 0.05) are represented by 162 (44.88 % of total differentially expressed small RNAs) molecules in shoot and 138 (7.14 %) in root; mainly various miR399 and miR827 isomiRs. The remaining small RNAs (i.e., those without perfect match to reference sequences deposited in miRBase) are considered as differentially expressed other sRNAs (DESs, p-value Bonferroni correction < 0.05). In roots, a more abundant and diverse set of other sRNAs (DESs, 1796 unique sequences, 0.13 % from total unique reads obtained under low-Pi) contributes more to the compensation of low-Pi stress than that in shoots (DESs, 199 unique sequences, 0.01 %). More than 80 % of differentially expressed other sRNAs are up-regulated in both organs. Additionally, in barley shoots, up-regulation of small RNAs is accompanied by strong induction of two nucleases (S1/P1 endonuclease and 3’-5’ exonuclease). This suggests that most small RNAs may be generated upon endonucleolytic cleavage to increase the internal Pi pool. Transcriptomic profiling of Pi-starved barley shoots identifies 98 differentially expressed genes (DEGs). A majority of the DEGs possess characteristic Pi-responsive cis-regulatory elements (P1BS and/or PHO element), located mostly in the proximal promoter regions. GO analysis shows that the discovered DEGs primarily alter plant defense, plant stress response, nutrient mobilization, or pathways involved in the gathering and recycling of phosphorus from organic pools.Conclusions: Our results provide comprehensive data to demonstrate complex responses at the RNA level in barley to maintain Pi homeostasis and indicate that barley adapts to Pi-starvation through elicitation of RNA degradation. Novel P-responsive genes were selected as putative candidates to overcome low-Pi stress in barley plants.
Deficiencies in the formation and regulation of anther cuticle and tryphine contribute to male sterility in cotton PGMS line
Authors: Zhang Meng , Liu Ji , Ma Qiang , Qin Yuan , Wang Hantao , Chen Pengyun , Ma Liang , Fu Xiaokang , Zhu Longfu , Wei Hengling , Yu Shuxun 
Published: September 2020

Abstract
Background: Male sterility is a simple and efficient pollination control system that is widely exploited in hybrid breeding. In upland cotton, CCRI9106, a photosensitive genetic male sterile (PGMS) mutant isolated from CCRI040029, was reported of great advantages to cotton heterosis. However, little information concerning the male sterility of CCRI9106 is known. Here, comparative transcriptome analysis of CCRI9106 (the mutant, MT) and CCRI040029 (the wild type, WT) anthers in Anyang (long-day, male sterile condition to CCRI9106) was performed to reveal the potential male sterile mechanism of CCRI9106.Results: Light and electron microscopy revealed that the male sterility phenotype of MT was mainly attributed to irregularly exine, lacking tryphine and immature anther cuticle. Based on the cytological characteristics of MT anthers, anther RNA libraries (18 in total) of tetrad (TTP), late uninucleate (LUNP) and binucleate (BNP) stages in MT and WT were constructed for transcriptomic analysis, therefore revealing a total of 870,4 differentially expressed genes (DEGs). By performing gene expression pattern analysis and protein-protein interaction (PPI) networks construction, we found down-regulation of DEGs, which enriched by the lipid biosynthetic process and the synthesis pathways of several types of secondary metabolites such as terpenoids, flavonoids and steroids, may crucial to the male sterility phenotype of MT, and resulting in the defects of anther cuticle and tryphine, even the irregularly exine. Furthermore, several lipid-related genes together with ABA-related genes and MYB transcription factors were identified as hub genes via weighted gene co-expression network analysis (WGCNA). Additionally, the ABA content of MT anthers was reduced across all stages when compared with WT anthers. At last, genes related to the formation of anther cuticle and tryphine could activated in MT under short-day condition.Conclusions: We propose that the down-regulation of genes related to the assembly of anther cuticle and tryphine may lead to the male sterile phenotype of MT, and MYB transcription factors together with ABA played key regulatory roles in these processes. The conversion of fertility in different photoperiods may closely relate to the functional expression of these genes. These findings contribute to elucidate the mechanism of male sterility in upland cotton.
­The effects of clinical decision support system for prescribing medication on patient outcomes and physician practice performance: a systematic review and meta-analysis
Authors: Moghadam Sharare Taheri , Sadoughi Farahnaz , Velayati Farnia , Ehsanzadeh Seyedjafar , Poursharif Shayan 
Published: September 2020

Abstract
Background: The clinical decision support systems (CDSSs) for prescribing is one of the technologies aimed at improving physician practice performance and patient outcomes by reducing medication prescription errors. This study, thus, was conducted to investigate the effect of various CDSSs on physician practice performance and patient outcomes.Methods: This systematic review was conducted by searching in PubMed, EMBASE, Web of Science, Scopus, and Cochrane Library from 2005 to 2019. Two researchers independently evaluated the studies. Any discrepancies over the eligibility of the studies between the two researchers were then resolved by consulting a third researcher. Finally, we extracted data from the articles. Then, we conducted a meta-analysis based on medication subgroups, CDSS type subgroups, and outcome categories. Also, we presented a narrative form of the findings. In the meantime, we applied random-effects model to estimate the effects of CDSS on patient outcomes and physician practice performance with 95% confidence interval. Q statistics and I2 were then used to measure heterogeneity.Results: Based on the inclusion criteria, 45 studies were considered eligible for the analysis in this review. The CDSS for prescribing medications/COPE were used for various diseases such as cardiovascular diseases, hypertension, diabetes, gastrointestinal and respiratory diseases, AIDS, appendicitis, kidney disease, malaria, high blood potassium, and mental diseases. Meanwhile, other cases such as the concurrent prescription of multiple drugs for patients and its effects on the above-mentioned outcomes were evaluated. The analysis shows that in some cases the application of CDSS provides positive effects on patient outcomes and physician practice performance (std diff in means = 0.114, 95% CI: 0.090 to 0.138). Also, it was statistically significant for outcome groups such as those showing improved outcomes on physician practice performance and patient outcome or both. However, no significant difference was observed between some other cases and conventional methods. We think that this could be due to the disease type, the quantity, and the type of CDSS requirements that influenced the comparison. Overall, all types of CDSSs have positive effects on outcomes including combinational types and other types that only cause messages when appropriate and necessary.Conclusions: Our findings suggest that positive effects of the CDSS can be attributed to factors such as user-friendliness, compliance with clinical guidelines, patient and physician cooperation, integration of electronic health records, CDSS and pharmaceutical systems, consideration of the views of physicians in assessing the importance of CDSS alerts, and the real-time alerts in the prescription.
The use of pre-operative Virtual Reality to reduce anxiety in women undergoing gynecological surgeries: a prospective cohort study
Authors: Chan Jason Ju In , Yeam Cheng Teng , Kee Hwei Min , Tan Chin Wen , Sultana Rehena , Sia Alex Tiong Heng , SNG Ban Leong 
Published: September 2020

Abstract
Background: Pre-operative anxiety is common and is associated with negative surgical outcomes. Virtual reality (VR) is a promising new technology that offers opportunities to modulate patient experience and cognition and has been shown to be associated with lower levels of anxiety. In this study, we investigated changes in pre-operative anxiety levels before and after using VR in patients undergoing minor gynecological surgery. Methods: Patients who underwent elective minor gynecological surgeries in KK Women’s and Children’s hospital, Singapore were recruited. The VR intervention consisted of 10-minute exposure via a headset loaded with sceneries, background meditation music and breathing exercises. For the primary outcome of pre-operative anxiety, patients were assessed at pre- and post-intervention using the Hospital Anxiety and Depression Scale (HADS). Secondary outcomes of self-reported satisfaction scores and EurQol 5-dimension 3-level (EQ-5D-3L) were also collected. Results: Data analysis from 108 patients revealed that HADS anxiety scores were significantly reduced from 7.2 ± 3.3 pre-intervention to 4.6 ± 3.0 post-intervention (p<0.0001). Furthermore, HADS depression scores were significantly reduced from 4.7 ± 3.3 pre-intervention to 2.9 ± 2.5 post-intervention (p<0.0001). Eighty-two percent of the patients self-reported VR intervention as ‘Good’ or ‘Excellent’. EQ-5D-3L showed significant changes in dimensions of ‘usual activities’ (p=0.025), ‘pain/discomfort’ (p=0.008) and ‘anxiety/ depression’ (p<0.0001). Conclusions: For patients undergoing minor gynecological procedures, the VR intervention brought about a significant reduction in pre-operative anxiety. This finding may be clinically important to benefit patients with high pre-operative anxiety without the use of anxiolytics. Trial registration: This study was registered on clinicaltrials.gov registry (NCT03685422) on 26 Sep 2018.
The emerging COVID-19 research: dynamic and regularly updated science maps and analyses
Authors: Andersen Njål , Bramness Jørgen Gustav , Lund Ingunn Olea 
Published: September 2020

Abstract
Background: The COVID-19 pandemic is a global public health emergency and experts emphasize the need for rapid and a high degree of communication and interaction between all parties, in order for critical research to be implemented. We introduce a resource (website) that provides bibliometric analysis showing the current content and structure of the published literature. As new research is published daily, the analysis is regularly updated to show the status as the research field develops and matures. Methods: Two bibliometric methods were employed, the first is a key-word co-occurrence analysis, based on published work available from PubMed. The second is a bibliometric coupling analysis, based on articles available through Scopus. The results are presented as clustered network graphs; available as interactive network graphs through the webpage. Results: For research as of March 23rd, keyword co-occurrence analysis showed that research was organized in 4 topic clusters: “Health and pandemic management”, “The disease and its pathophysiology”, “Clinical epidemiology of the disease” and “Treatment of the disease”. Coupling analyses resulted in 4 clusters on literature that relates to “Overview of the new virus”, “Clinical medicine”, “On the virus” and “Reproduction rate and spread”. Conclusions: We introduced a dynamic resource that will give a wide readership an overview of how the structure of the COVID-19 literature is developing. To illustrate what this can look like, we showed the structure as it stands three months after the virus was identified; the structure is likely to change as we progress to later stages of this pandemic.
Evaluation of sensitivity and specificity of CanPatrolTM technology for detection of circulating tumor cells in patients with non-small cell lung cancer
Authors: Li Jingyao , Liao Yi , Ran Yaling , Wang Guiyu , Wu Wei , Qiu Yang , Liu Jie , Wen Ningyu , Jing Tao , Wang Haidong , Zhang Shixin 
Published: September 2020

Abstract
Background: The early diagnosis of non-small cell lung cancer is of great significance to the prognosis of patients. However, traditional histopathology and imaging screening have certain limitations. Therefore, new diagnostical methods are urgently needed for the current clinical diagnosis. In this study we evaluated the sensitivity and specificity of CanPatrolTM technology for the detection of circulating tumor cells in patients with non-small cell lung cancer (NSCLC). Methods: CTCs in the peripheral blood of 98 patients with NSCLC and 38 patients with benign pulmonary diseases were collected by the latest typing of CanPatrolTM detection technology. A 3-year follow-up was performed to observe their recurrence and metastasis. Kruskal-Wallis test was used to compare multiple groups of data, Mann-Whitney U test was used to compare data between the two groups, and ROC curve analysis was used to obtain the critical value. The COX risk regression and Kaplan-Meier survival analysis were performed in the 63 NSCLC patients who were effectively followed up. Results: The epithelial, epithelial-mesenchymal, and total CTCs were significantly higher in NSCLC patients than that in patients with benign lung disease (P < 0.001). The mesenchymal CTCs of NSCLC patients was slightly higher than that of benign lung diseases (P = 0.013). The AUC of the ROC curve of the total CTCs was 0.837 (95% CI: 0.76-0.914), and the cut-off value corresponding to the most approximate index was 0.5 CTCs/5 ml, at which point the sensitivity was 81.6% and the specificity was 86.8%. COX regression analysis revealed that the clinical stage was correlated with patient survival (P = 0.006), while gender, age, and smoking were not (P > 0.05). After excluding the confounders of staging, surgery, and chemotherapy, Kaplan-Meier survival analysis showed that patients in stage IIIA with CTCs ≥ 0.5 had significantly lower DFS than those with CTCs < 0.5 (P = 0.022). Conclusions: CTC positive can well predict the recurrence of NSCLC patients. CanPatrolTM technology has good sensitivity and specificity in detecting CTCs in peripheral blood of NSCLC patients and has a certain value for clinical prognosis evaluation.
Clinical characteristics and manifestations in older patients with COVID-19
Authors: Wei Chenchen , Liu Ya , Liu Yapeng , Zhang Kai , Su Dezhen , Zhong Ming , Meng Xiao 
Published: September 2020

Abstract
Background: To investigate the clinical characteristics and manifestations of older patients with coronavirus disease 2019 (COVID-19).Methods: In this retrospective study, 566 patients with confirmed COVID-19 were enrolled and the clinical characteristics, laboratory findings, complications and outcome data were collected and analyzed.Results: Among the 566 patients (median age, 61.5 years) with COVID-19, 267 (47.2%) patients were male and 307 (54.2%) were elderly. Compared with younger patients, older patients had more underlying comorbidities and laboratory abnormalities. A higher rate of acute respiratory distress syndrome (ARDS), acute cardiac injury and heart failure was observed in the older group as compared with younger and middle-aged groups, particularly those oldest-old patients (>75 years) had more multi-organ damage. Older patients with COVID-19 were more likely to suffer from acute cardiac injury in cases with preexistenting cardiovascular diseases, while there was no difference among the three groups when patients had no history of cardiovascular diseases. Older patients present more severe with the mortality of 18.6%, which was higher than that in younger and middle-aged patients (P<0.05). Multivariable analysis showed that age, lymphopenia, ARDS, acute cardiac injury, heart failure and skeletal muscle injury were associated with death in older patients, while glucocorticoids may be harmful.Conclusions: Older patients, especially the oldest-old patients were more likely to exhibit significant systemic inflammation, pulmonary and extrapulmonary organ damage and a higher mortality. Advanced age, lymphopenia, ARDS, acute cardiac injury, heart failure and skeletal muscle injury were independent predictors of death in older patients with COVID-19 and glucocorticoids should be carefully administered in older patients.