bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rising public piety and the status of women in Indonesia two decades after reformasi
Authors: Afrianty Dina 
Published: November 2019

AbstractIndonesian women were at the forefront of activism during the turbulent period prior toreformasiand were a part of the leadership that demanded democratic change. Two decades after Indonesia embarked on democratic reforms, the country continues to face challenges on socio-religious and political fronts. Both the rise of political Islam and the increased presence of religion and faith in the public sphere are among the key features of Indonesia's consolidating democracy. This development has reinvigorated the discourse on citizenship and rights and also the historical debate over the relationship between religion and the state. Bearing this in mind, this paper looks at the narrative of women's rights and women's status in the public domain and public policy in Indonesia. It is evident, especially in the past decade, that much of the public conversation within the religious framework is increasingly centred on women's traditional social roles. This fact has motivated this study. Several norms and ideas that are relied on are based on cultural and faith-based interpretations - of gender. Therefore, this paper specifically examines examples of the ways in which social, legal, and political trends in this context affect progress with respect to gender equality and gender policy. I argue that these trends are attempts to subject women to conservative religious doctrines and to confine them to traditional gender roles. The article discusses how these developments should be seen in the context of the democratic transition in Indonesia.
Decadal‐Scale Aquifer Dynamics and Structural Complexities at a Municipal Wellfield Revealed by 25 Years of InSAR and Recent Groundwater Temperature Observations
Authors: Grapenthin Ronni , Kelley Shari , Person Mark , Folsom Matthew 
Published: November 2019

AbstractOver the past 35 years the Buckman wellfield near Santa Fe, New Mexico, experienced production well drawdowns in excess of 180 m, resulting in ground subsidence and surface cracks. Increased reliance on surface water diversions since 2011 has reduced pumping and yielded water level recovery. To characterize the impact of wellfield management decisions on the aquifer system, we reconstruct the surface deformation history through the European Remote Sensing Satellite, Advanced Land Observing Satellite, and Sentinel‐1 Interferometric Synthetic Aperture Radar (InSAR) time series analysis during episodes of drawdown (1993–2000), recovery (2007–2010), and modern management (2015–2018) in discontinuous observations over a 25‐year period. The observed deformation generally reflects changes in hydraulic head. However, at times during the wellfield recovery, the deformation signal is complex, with patterns of uplift and subsidence suggesting a compartmentalized aquifer system. Recent records of locally high geothermal gradients and an overall warming of the system (~0.5°C during the water level recovery) obtained from repeat temperature measurements between 2013 and 2018 constrain a conceptual model of convective heat transfer that requires a vertical permeable zone near an observed fault. To reproduce observed temperature patterns at monitoring wells, high basal heat flow and convective cooling associated with downward flow of water from cool shallow aquifers during the drawdown period is necessary. The fault, however, appears to die out southward or may be locally permeable, as conceptual cross‐sectional hydrologic modeling reproduces the surface deformation without such a structure. Our work demonstrates the importance of incorporating well‐constrained stratigraphy and structure when modeling near‐surface deformation induced by, for instance, groundwater production.
Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression
Authors: Hu Linyi , Sun Yin , Luo Jie , He Xiang , Ye Meihua , Li Gonghui , Zhang Yong , Bai Jian , Zhang Dahong , Chang Chawnshang 
Published: November 2019

AbstractProstate cancer (PCa) is the second leading cause of cancer death in men in America, and there are no curative options for metastatic castration-resistant prostate cancer (mCRPC). Docetaxel (DTX) has been used as a standard chemotherapy for the mCRPC. However, resistance to DTX is a significant clinical problem as half of patients fail to respond to therapy. The TR4 nuclear receptor has been reported to play an important role in PCa progression, however, its linkage to the DTX resistance remains unclear. Here we found that TR4 was upregulated after DTX chemotherapy in the mCRPC cells and patients, and TR4 expression is correlated with DTX sensitivity with a higher level conferring chemo-resistance. Targeting TR4 with an antagonist bexarotene (Bex, a derivative of retinoid) suppressed the TR4 transactivation with increased DTX chemo-sensitivity. Mechanism dissection studies revealed that TR4 might alter the DTX chemo-sensitivity via modulating the TR4/lincRNA-p21/HIF-1α/VEGF-A signaling. Together, these results suggest that targeting this newly identified TR4/lincRNA-p21/HIF-1α/VEGF-A signaling with Bex, an FDA-approved drug, may increase the DTX chemo-sensitivity to better suppress the mCRPC progression.
Correction: Single-cell genomics shedding light on marine Thaumarchaeota diversification
Authors: Luo Haiwei , Tolar Bradley B , Swan Brandon K , Zhang Chuanlun L , Stepanauskas Ramunas , Moran Mary Ann , Hollibaugh James T 
Published: November 2019

Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Rethinking calcium profiles around single channels: the exponential and periodic calcium nanodomains
Authors: Mironov Sergej L. 
Published: November 2019

AbstractMany fundamental calcium-dependent physiological processes are triggered by high local calcium levels that are established around the sites of calcium entry into the cell (channels). They are dubbed as calcium nanodomains but their exact profiles are still elusive. The concept of calcium nanodomains stems from a linear model of calcium diffusion and is only valid when calcium increases are smaller than the concentration of cytoplasmic buffers. Recent data indicates that much higher calcium levels cause buffer saturation. Therefore, I sought explicit solutions of a nonlinear reaction-diffusion model and found a dichotomous solution. For small fluxes, the steady state calcium profile is quasi-exponential, and when calcium exceeds buffer concentration a spatial periodicity appears. Analytical results are supported by Monte-Carlo simulations. I also imaged 1D- and radial calcium distributions around single α-synuclein channels in cell-free conditions. Measured Ca profiles are consistent with theoretical predictions. I propose that the periodic calcium patterns may well arise under certain conditions and their specific functional role has to be established.
New bioresorbable wraps based on oxidized polyvinyl alcohol and leukocyte-fibrin-platelet membrane to support peripheral nerve neurorrhaphy: preclinical comparison versus NeuraWrap
Authors: Stocco Elena , Barbon Silvia , Macchi Veronica , Tiengo Cesare , Petrelli Lucia , Rambaldo Anna , Borean Alessio , Capelli Stefano , Filippi Andrea , Romanato Filippo , Parnigotto Pier Paolo , Grandi Claudio , De Caro Raffaele , Porzionato Andrea 
Published: November 2019

AbstractNerve wrapping improves neurorrhaphy outcomes in case of peripheral nerve injuries (PNIs). The aim of this preclinical study was to assess the efficacy of two novel biodegradable wraps made of a synthetic 1% oxidized polyvinyl alcohol (OxPVA) and a natural leukocyte-fibrin-platelet membrane (LFPm) versus the commercial product NeuraWrap. After rats sciatic nerve transection and neurorrhaphy, the wraps were implanted and compared for functional outcome, by sciatic function index assessment; structural characteristics, by histological/immunohistochemical analysis; ultrastructural features, by transmission electron microscopy. Moreover, a morphometric study was also performed and collagen distribution was observed by Second Harmonic Generation microscopy. After 12 weeks from implantation, all wraps assured nerve function recovery; no scar tissue/neuromas were visible at dissection. LFPm wraps were completely resorbed, while residues of OxPVA and NeuraWrap were observed. In all groups, biocompatibility was confirmed by the absence of significant inflammatory infiltrate. According to histological/immunohistochemical analysis and morphometric findings, OxPVA and LFPm wraps were both effective in preserving nerve integrity. These results assess that bioengineered OxPVA and LFPm wraps successfully guarantee favorable lesion recovery after PNI/neurorrhaphy and, in future, may be considered an interesting alternative to the commercial NeuraWrap.
Prognostic effects of clinical and CT imaging features on critically ill patients with interstitial lung disease hospitalized in respiratory intensive care unit
Authors: Shi Shenyun , Xiao Yonglong , Qiu Xiaohua , Li Yan , Qiu Yuying , Zhou Kefeng , Cai Hourong 
Published: November 2019

AbstractThe study aimed to evaluate the clinical and imaging features of critically ill patients with interstitial lung disease (ILD) treated in respiratory intensive care unit (RICU) and assess the prognostic effects of these factors. A total of 160 severe ILD patients admitted to the RICU were finally enrolled in this study. The clinical, imaging and follow-up data of them were studied retrospectively. The in-hospital mortality and total mortality were 43.1% and 63.8% respectively. By multivariate cox regression analysis, shock (OR = 2.39, P = 0.004), pulmonary fibrosis on CT (OR = 2.85, P = 0.002) and non-invasive ventilation (OR = 1.86, P = 0.037) were harmful factors to survivals of critically ill patients with ILD. In contrast, oxygenation index (OR = 0.99, P = 0.028), conventional oxygen therapy (OR = 0.59, P = 0.048) and β-lactam antibiotics use (OR = 0.51, P = 0.004) were protective factors. There is significant difference of survivals between patients with and without fibrosing ILD on CT (Log-rank, p = 0.001). The prognosis of critically ill patients with ILD was poor. Shock, respiratory failure and fibrosing signs on chest CT affected the prognosis. Chest CT was considered as a valuable tool to indicate the prognosis.
The Effect of Symbol Background Color on the Speed of Locating Targets by Adults Without Disabilities: Implications for Augmentative and Alternative Communication Display Design
Authors: Thistle Jennifer J. 
Published: November 2019

Purpose
Previous research with children with and without disabilities has demonstrated that visual–perceptual factors can influence the speech of locating a target on an array. Adults without disabilities often facilitate the learning and use of a child's augmentative and alternative communication system. The current research examined how the presence of symbol background color influenced the speed with which adults without disabilities located target line drawings in 2 studies.

Method
Both studies used a between-subjects design. In the 1st study, 30 adults (ages 18–29 years) located targets in a 16-symbol array. In the 2nd study, 30 adults (ages 18–34 years) located targets in a 60-symbol array. There were 3 conditions in each study: symbol background color, symbol background white with a black border, and symbol background white with a color border.

Results
In the 1st study, reaction times across groups were not significantly different. In the 2nd study, participants in the symbol background color condition were significantly faster than participants in the other conditions, and participants in the symbol background white with black border were significantly slower than participants in the other conditions.

Conclusion
Communication partners may benefit from the presence of background color, especially when supporting children using displays with many symbols.
High-resolution spectropolarimetric observations of the temporal evolution of magnetic fields in photospheric bright points
Authors: Keys P. H. , Reid A. , Mathioudakis M. , Shelyag S. , Henriques V. M. J. , Hewitt R. L. , Del Moro D. , Jafarzadeh S. , Jess D. B. , Stangalini M. 
Published: November 2019

Context.Magnetic bright points (MBPs) are dynamic, small-scale magnetic elements often found with field strengths of the order of a kilogauss within intergranular lanes in the photosphere.Aims.Here we study the evolution of various physical properties inferred from inverting high-resolution full Stokes spectropolarimetry data obtained from ground-based observations of the quiet Sun at disc centre.Methods.Using automated feature-tracking algorithms, we studied 300 MBPs and analysed their temporal evolution as they evolved to kilogauss field strengths. These properties were inferred using both the NICOLE and SIR Stokes inversion codes. We employ similar techniques to study radiative magnetohydrodynamical simulations for comparison with our observations.Results.Evidence was found for fast (∼30−100 s) amplification of magnetic field strength (by a factor of 2 on average) in MBPs during their evolution in our observations. Similar evidence for the amplification of fields is seen in our simulated data.Conclusions.Several reasons for the amplifications were established, namely, strong downflows preceding the amplification (convective collapse), compression due to granular expansion and mergers with neighbouring MBPs. Similar amplification of the fields and interpretations were found in our simulations, as well as amplification due to vorticity. Such a fast amplification will have implications for a wide array of topics related to small-scale fields in the lower atmosphere, particularly with regard to propagating wave phenomena in MBPs.
Skaphoidpseudarthrosen – wenn das Kahnbein nicht heilen will
Authors: Oeckenpöhler Simon , Ueberberg Johanna , Raschke Michael J. , Langer Martin F. 
Published: November 2019

ZusammenfassungKahnbeinbrüche sind die häufigsten knöchernen Läsionen des Karpus. Da sie nicht selten wenig klinische Symptome hervorrufen, werden diese Frakturen bei unzureichender Diagnostik häufig übersehen und mangelhaft therapiert. Deshalb ist bei klinischem Verdacht ein Frakturausschluss mittels Schichtbildgebung obligat. Anhand der CT kann der Bruch des Kahnbeins nach Krimmer und Herbert klassifiziert und davon abhängig die Therapie festgelegt werden. Da auch die Durchblutung des Kahnbeins recht fragil ist, kommt es in bis zu 37% der konservativen Therapien mittels Ruhigstellung bei „stabilen“ Typ A Verletzungen zur Ausbildung einer Pseudarthrose. Selbst operativ stabilisierte Typ B Verletzungen haben ein Pseudarthroserisiko von bis zu 10%. Es werden straffe Pseudarthrosen von instabilen Pseudarthrosen unterschieden. Erstere lassen sich oft minimalinvasiv mit perkutaner Schraubenosteosynthese therapieren, letztere müssen meist offen mit Interposition eines Spongiosatransplantes oder eines (vaskularisierten) Knochenspanes versorgt werden, um diese zur Ausheilung zu bringen. Zuvor muss hier die Stellung mittels Dünnschicht-CT und die Vitalität der Fragmente mittels Kontrastmittel-MRT detektiert werden. Unversorgte Skaphoidpseudarthrosen führen zur Instabilität des karpalen Gefüges und über einen karpalen Kollaps häufig zur Handgelenksarthrose.
Die schlecht heilende proximale Tibiafraktur – Infektion, Malunion, Delayed Union, Nonunion – was nun?
Authors: Schoof Benjamin , Hissnauer Tim-Nicolas , Klatte Till Orla , Frosch Karl-Heinz 
Published: November 2019

ZusammenfassungDie Fraktur der proximalen Tibia mit und ohne Gelenkbeteiligung ist eine schwere und komplikationsträchtige Verletzung. Sie stellt Patienten und Behandler aufgrund der operativen Anforderungen und individuellen Behandlung vor eine herausfordernde Aufgabe. Im folgenden Artikel werden Risiken und Komplikationen dargestellt sowie mögliche Behandlungspfade aufgezeigt.
Intraoperatives Neuromonitoring in der Wirbelsäulenchirurgie
Authors: Shiban Ehab , Ille Sebastian , Meyer Bernhard 
Published: November 2019

ZusammenfassungDas intraoperative Neuromonitoring (IONM) findet abgesehen von seiner Anwendung bei der Resektion von supratentoriellen Raumforderungen auch Anwendung in der Wirbelsäulenchirurgie. Hier muss einerseits zwischen verschiedenen Indikationen für den Einsatz des IONM, sowie den einzelnen IONM-Modalitäten unterschieden werden. Diese werden teilweise kontrovers diskutiert. Im folgenden Artikel sollen sowohl die Indikationen wie auch die Modalitäten des IONM in der Wirbelsäulenchirurgie beschrieben und basierend auf der aktuellen Evidenz diskutiert werden.
Atypically Located Osteoid Osteoma: Characteristics and Therapeutic Success After Image-Guided Thermal Ablation
Authors: Seemann Ricarda Johanna , Märdian Sven , Schwabe Philipp , Streitparth Florian 
Published: November 2019

Purpose While ostoeid osteomas (OO) are typically located in long tubular bones, OO occurring elsewhere are referred to as “atypical”. Aim of our study was to review the characteristics of atypically located OO, course of symptoms and therapy, as well as clinical outcome, safety, and patient satisfaction of radiofrequency ablation (RFA).
Materials and methods In the period from 04/01 to 07/13, 33 patients were treated using thermal ablation (RFA or laser), partly with low temperature and short duration technique. Clinical records were analyzed. Additionally, 23 patients were interviewed via telephone. Primary endpoints were technical success, clinical success (recurrence rates), and adverse events. Secondary endpoints were course of symptoms and therapy as well as patient satisfaction.
Results Mean follow-up was 22.1 ± 21.5 months. Average patient age was 31.7 ± 16.3 years. Localization: Most atypical OO (61 %) were located in the lower extremity, followed by axial skeleton (26 %) and upper extremity (13 %). Pain anamnesis: 74 % of patients stated that their pain occured predominantly at night and responded to NSAID, as typical for OO. Diagnostics: Patients consulted on average 4 different doctors and in 52 % patients, ≥ 3 different radiologic imaging techniques where used before the diagnosis “OO” was made. Outcome: Technical success of thermal ablation was 100 %. Primary clinical success was 91 %. Patient satisfaction was 100 %. No major complications occurred.
Conclusion In ¼ of cases, atypical OO did not show the typical pain characteristics of OO. Image-guided thermal ablation is a promising and safe therapy also for patients with atypical OO.
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Citation Format
Kenntnisse von deutschsprachigen Urologen zur Häufigkeit der Assoziation des Peniskarzinoms mit dem Humanen Papillomavirus – Survey-Ergebnisse der European PROspective Penile Cancer Study (E-PROPS)
Authors: Lebentrau Steffen , Wolff Ingmar , Hempel Marie Christine , Haccius Marlene , Kluth Luis A. , Pycha Armin , Brookman-May Sabine , Schneider Till Rasmus , Hermanns Thomas , Distler Florian A. , Boegemann Martin , Kübler Hubert , Shariat Shahrokh F. , Burger Maximilian , May Matthias 
Published: November 2019

Zusammenfassung
Hintergrund Gemäß einer aktuellen Metaanalyse zeigt in Europa jeder zweite Patient mit einem Peniskarzinom (PeK) eine Assoziation mit dem Humanen Papillomavirus (HPV). Es liegen keine Daten darüber vor, inwieweit UrologInnen die Häufigkeit dieser viralen Karzinogenese kennen.
Methoden Es wurde ein 14-Items umfassender deutschsprachiger Survey erstellt und in Q3/2018 einmalig an UrologInnen von 45 Kliniken in Deutschland (n = 34), Österreich (n = 8), der Schweiz (n = 2) und Italien/Südtirol (n = 1) verschickt. Insgesamt waren nach vorher definiertem Qualitätsstandard 557 Fragebögen auswertbar (mediane Rücklaufquote 85,7 %). In dem Survey wurde u. a. nach der Häufigkeit HPV-assoziierter PeK in Europa gefragt und 4 Antwortmöglichkeiten vorgegeben: (A)-„< 25 %“, (B)-„25 – 50 %“, (C)-„> 50 – 75 %“, (D)-„kein Wissen über die Häufigkeit des Zusammenhangs“. Es wurde in der Auswertung eine Toleranz von 50 % akzeptiert, sodass B und C (25 – 75 %) als korrekte Antworten gewertet wurden. Mittels eines Bootstrap-korrigierten multivariaten logistischen Regressionsmodells wurden Kriterien identifiziert, die unabhängig eine richtige Antwort der Befragten vorhersagten.
Ergebnisse Die Kategorien A – D wurden von 19,2 % (n = 107), 48,8 % (n = 272), 12,9 % (n = 72) bzw. 19 % (n = 106) als Antwort gewählt, sodass der Endpunkt von 61,8 % (n = 344) der UrologInnen erreicht wurde (B + C). Die selbstständige Durchführung der Chemotherapie durch die Urologische Klinik (OR 1,55; p[Bootstrap] = 0,036) und die Anzahl der urologischen Klinikbetten (OR 1,02; p[Bootstrap] = 0,025) waren die einzigen Studienkriterien, die signifikant das richtige Ergebnis prädizierten. Der Status einer Universitätsklinik (p = 0,143), eine leitende Position der UrologInnen (p = 0,375) bzw. die jährliche Anzahl behandelter PeK-Patienten (p = 0,571) blieben hingegen ohne signifikanten Einfluss auf den Endpunkt.
Schlussfolgerung Unsere Studienergebnisse zeigen, dass sich deutschsprachige Klinik-UrologInnen der Häufigkeit einer gegenwärtigen HPV-Assoziation des PeK nur unzureichend bewusst sind.
Spontaneous Remission of Sick Sinus Syndrome in a Fetus with Pulmonary Stenosis Regurgitation
Authors: Kajiwara Kazuhiro , Ishikawa Satoru , Mori Takuma , Samura Osamu , Okamoto Aikou 
Published: November 2019

Objective Here, we report a case of fetal sick sinus syndrome (SSS) caused by pulmonary stenosis regurgitation (PSR) that spontaneously resolved during pregnancy.
Case Report A 29-year-old woman was referred to our hospital at 21 weeks of gestation for persistent fetal bradycardia. Fetal echocardiography revealed PSR and ventricular septal defect (VSD). The ventricular rate was 60 to 70 beats/minute with 1:1 atrioventricular conduction. Thus, congenital SSS owing to PSR was suspected. During pregnancy, fetal SSS spontaneously resolved at 28 weeks of gestation despite persistent PSR. The ventricular rate was increased to approximately 120 beats/minute with regular rhythm. A 2,390-g male neonate was delivered via Caesarean section at 38 weeks of gestation. Consequently, detailed echocardiography revealed PSR and VSD without SSS.
Conclusion Although fetal PSR can cause fetal SSS owing to immaturity at an earlier gestational age, SSS might be spontaneously resolved by fetal heart development as pregnancy progresses.
Dynamic Weight-bearing Magnetic Resonance in the Clinical Diagnosis of Internal Temporomandibular Joint Disorders
Authors: Giannini Silvana , Chiogna Giorgio , Balzano Rosario Francesco , Guglielmi Giuseppe 
Published: November 2019

AbstractTemporomandibular joint (TMJ) disorders can be painful and cause functional limitations and bone changes. Deeper clinical knowledge of the pathologies related to the TMJ has always been hindered by the difficult identification of the causes that limit its movement. Weight-bearing magnetic resonance imaging (WBMRI) can reproduce the articular movement in orthostasis and allows the evaluation of joint movement. WBMRI, compared with other procedures such as double-type condylography and real-time dynamic ultrasound, helps to better identify tissue characteristics of the articular glenoid-condylar surfaces, articular space, disk position on both the open and closed mouth, and the locoregional musculotendinous area. WBMRI also identifies the true position of the articular disk in orthostasis, emphasizing the different joint positions compared with the study carried out in a clinostatic (supine) position.