bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine-Mapping Complex Inversion Breakpoints and Investigating Somatic Pairing in theAnopheles gambiaeSpecies Complex Using Proximity-Ligation Sequencing
Authors: Corbett-Detig Russell B , Said Iskander , Calzetta Maria , Genetti Max , McBroome Jakob , Maurer Nicholas W , Petrarca Vincenzo , della Torre Alessandra , Besansky Nora J 
Published: October 2019

AbstractIn this work, Corbett-Detig et al. use proximity-ligation sequencing (Hi-C) of several Anopheles gambiae and A. coluzzii inversionbearing individuals to detect and map inversion breakpoints. They show that inversion breakpoints can be mapped precisely...Chromosomal inversions are fundamental drivers of genome evolution. In the main Afrotropical malaria vector species, belonging to the Anopheles gambiae species complex, inversions play an important role in local adaptation and have a rich history of cytological study. Despite the importance and ubiquity of some chromosomal inversions across the species complex, inversion breakpoints are often challenging to map molecularly due to the presence of large repetitive regions. Here, we develop an approach that uses Hi-C sequencing data to molecularly fine-map the breakpoints of inversions. We demonstrate that this approach is robust and likely to be widely applicable for both identification and fine-mapping inversion breakpoints in species whose inversions have heretofore been challenging to characterize. We apply our method to interrogate the previously unknown inversion breakpoints of 2Rbc and 2Rd in An. coluzzii. We found that inversion breakpoints occur in large repetitive regions, and, strikingly, among three inversions analyzed, two breakpoints appear to be reused in two separate inversions. These breakpoint-adjacent regions are strongly enriched for the presence of a 30 bp satellite repeat sequence. Because low frequency inversion breakpoints are not correlated with genomic regions containing this satellite, we suggest that interrupting this particular repeat may result in arrangements with higher relative fitness. Additionally, we use heterozygous individuals to quantitatively investigate the impacts of somatic pairing in the regions immediately surrounding inversion breakpoints. Finally, we discuss important considerations for possible applications of this approach for inversion breakpoint identification in a range of organisms.
The EORTC QLQ-C30 Summary Score as Prognostic Factor for Survival of Patients with Cancer in the “Real-World”: Results from the Population-Based PROFILES Registry
Authors: Husson Olga , de Rooij Belle H. , Kieffer Jacobien , Oerlemans Simone , Mols Floortje , Aaronson Neil K. , van der Graaf Winette T.A. , van de Poll-Franse Lonneke V. 
Published: October 2019

Abstract

Background
Health-related quality of life (HRQoL) has been shown to be a prognostic factor for cancer survival in randomized clinical trials and observational “real-world” cohort studies; however, it remains unclear which HRQoL domains are the best prognosticators. The primary aims of this population-based, observational study were to (a) investigate the association between the novel European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core30 (QLQ-C30) summary score and all-cause mortality, adjusting for the more traditional sociodemographic and clinical prognostic factors; and (b) compare the prognostic value of the QLQ-C30 summary score with the global quality of life (QoL) and physical functioning scales of the QLQ-C30.

Materials and Methods
Between 2008 and 2015, patients with cancer (12 tumor types) were invited to participate in PROFILES disease-specific registry studies (response rate, 69%). In this secondary analysis of 6,895 patients, multivariate Cox proportional hazard regression models were used to investigate the association between the QLQ-C30 scores and all-cause mortality.

Results
In the overall Cox regression model including sociodemographic and clinical variables, the QLQ-C30 summary score was associated significantly with all-cause mortality (hazard ratio [HR], 0.77; 99% confidence interval [CI], 0.71–0.82). In stratified analyses, significant associations between the summary score and all-cause mortality were observed for colon, rectal, and prostate cancer, non-Hodgkin lymphoma, chronic lymphocytic leukemia, and multiple myeloma. The QLQ-C30 summary score had a stronger association with all-cause mortality than the global QoL scale (HR, 0.82; 99% CI, 0.77–0.86) or the physical functioning scale (HR, 0.81; 95% CI, 0.77–0.85).

Conclusion
In a real-world setting, the QLQ-C30 summary score has a strong prognostic value for overall survival for a number of populations of patients with cancer above and beyond that provided by clinical and sociodemographic variables. The QLQ-C30 summary score appears to have more prognostic value than the global QoL, physical functioning, or any other scale within the QLQ-C30.
El QUADRIVIUM Y LA CATEDRAL GÓTICA
Authors: Teruel Cinta Lluis 
Published: October 2019

Los promotores de las catedrales idealizaban en los fundamentos del quadrivium el orden gótico. El Capítulo catedral tenía un conocimiento de la ciencia matemática especulativo, derivado de las fuentes patrísticas y los enciclopedistas latinos neoplatónicos. La síntesis de estas fuentes, con una métrica de base aritmética y geométrica que se despliega como un gran ábaco, la geometria fabrorum del constructor medieval, permite construir las catedrales góticas. Se plantea la relación entre la teoría de la proporción de los codex existentes en el Archivo Capitular de Tortosa y la de la fábrica gótica.
The Reception of the Engravings of Gottfried Bernhard Göz’s Marian Series in the Monumental Painting of the Lviv Circle in the 18th Century
Authors: Dzik Janina 
Published: October 2019

The Polish version of the article was published in Roczniki Humanistyczne vol. 63, issue 4 (2015).
The graphic series dedicated to the Mother of God, defined as Sub tuum praesidium confugimus, by Gottfried Bernhard Göz (1708–1774) was an inspiration for the monumental painting of the Rococo period in Poland in the times of the Saxon kings. The series of engravings with a devotional character made with the stipple engraving technique presents 12 signed Marian scenes: the Immaculate Conception of the Blessed Virgin Mary, Mary’s Birth, the Presentation of Mary, Mary and Joseph’s Matrimony, the Annunciation, the Visitation, the Purification, the images of Our Lady of Sorrows, and the Assumption. Other scenes are connected with Mary’s patronage – as the Queen of the Rosary—and her intercession. The prints, as researchers of Göz’s work assume, prove his mature style that was shaped in the years 1737–1740, when he formed a publishing “company” together with the Klauber brothers, Joseph Sebastian and Johann Baptist. He used the motifs occurring in the series many times e.g. on the vault of the nave in the Dominican nuns’ St Stefan Church in Habsthal (1748; Upper Swabia), in the sketch and painting for the Cistercian monastery in Birnau (1748–1750). These motifs were also found in Bavarian Marian shrines, e.g. Frauenchiemsee, Maria Mitleid Kapelle and Mater Dolorosa Kapelle with paintings by Balthasar Furtner (1761) and in a church in Niederaschau and Kleinmariazell (1763–1765). References to the series may also be found in the area of Slovenia, i.e. on the vault of Grajska Kapela in Novo Celje (1758–1763).
The prints were known to the circle of Lviv artists active in the 18th century and they were used as models for numerous figural compositions. First of all the Lviv painter Stanisław Stroiński (1719–1802) used them for the decorations, among others, of the interior of the Franciscan Marian sanctuary in Leżajsk, in the Franciscan Holy Spirit Church in Krystynopol (1756–1759 (now Chervonohrad in Ukraine), and in the decoration of St Anne’s Chapel in the Holy Trinity Benedictine Church in Przemyśl. The series of prints was also used by the painter Gabriel Sławiński in the decoration of the chancel in St Lawrence Parish Church in the village of Żółkiewka and on the vault of the post-Pauline St Louis Church in Włodawa.
The engravings are a significant model for Polish painting because of their style, technique and original approach to the conventional religious theme.
Ludomir Sleńdziński’s Trips to Italy 1923–1925
Authors: Nowakowska-Sito Katarzyna 
Published: October 2019

The Polish version of the article was published in Roczniki Humanistyczne vol. 60, issue 4 (2012).
Ludomir Sleńdziński was the main representative of classicism in Polish art in the period between the two World Wars. The article discusses his two trips to Italy in 1922/24 and 1924/25. They have not been yet researched in the context of the origin and character of his work, albeit impulses coming from Italy were thought to have been an important catalyst for the birth of the so-called “return to order.”
Sleńdziński was Dmitry Kardovsky’s student at the Academy of Fine Arts in Sankt Petersburg, and it was in his class that he acquired a worship of the old masters and a perfect command of his trade, first of all perfect drawing skills. Apart from the Sankt Petersburg school, classicist trends came to Polish art from Paris where they were first noticed in the circles connected with the Museion magazine (1911-1913) and among artists belonging to the Polish colony, such as Henryk Kuna, Edward Wittig and Eugeniusz Żak.
In the article, I reconstruct Sleńdziński’s tour of Italy, and I remind about the exhibition of Polish modern art that he staged in 1925 as part of the 3rd Roman Biennale. His personal contact with old and modern Italian art became an important moment in his artistic formation, stimulating his departure from academic towards modern classicism, in which the artist starts playing a game with the present day and with tradition, consciously using stylistic elements that belong to different epochs.
In conclusion it must be said that Ludomir’s trips inclined him to introduce many new solutions (sometimes surprisingly close to works by well-known Italian artists of similar outlook) and determined the final shape of his mature work.
INNOVATION IN ENTREPRENEURSHIP EDUCATION THROUGH COMPETITION BASED LEARNING ROLE: STUDENTS’ PERSPECTIVE ON THE ENHANCEMENT OF SOFT SKILLS
Authors: Abushakra Ahmad , Firdouse Rahman Khan M. , Abdul Wahhab Rasha , Al Maqbali Hilal 
Published: October 2019

Purpose: The objective of the study is to critically analyze the impact of entrepreneurial competitions on the soft skills of Omani students.
Design/methodology/approach: Purposive sampling methodology was adopted to perform the study. A sample of 125 students was selected among the 450 students from various Higher Education Institutions (HEIs) who participated in the entrepreneurship competition. The questionnaire was distributed two times to the students before and after the competition and 110 fully completed questionnaires only were taken into the research study. Using SPSS, statistical tests like non-parametric chi-square test, t-paired sample test, and Kolmogorov-Smirnov test were carried out the results were interpreted.
Findings: The findings of the empirical study suggest that competitions have a positive impact on the students’ soft skills and their mindset after participating in the competitions. The study also confirmed that competition is an encouraging affair that makes the students learn new skills and new developments in the business fields. Further, the study also confirmed that competition makes it easy to explore the labor market in the area of requirements.
Research limitations/Implications: HEIs should motivate and encourage students to participate in various entrepreneurial competitions inducing a spirit of entrepreneurship among the young students to enhance their soft skills for self-sufficiency and to identify the potentialities vested within them.
Social implications: The study suggests that to improve the entrepreneurial mindsets of young students, and universities. Originality/Value Only a very few have examined the role of entrepreneurship education in developing soft skills through competition-based learning in Oman. Our study includes selected students from HEIs of Oman the study can further be extended to all the HEIs across Oman.
El fascismo en la pantalla: Vincere (Italia, Bellochio, 2009)
Authors: Marzorati Zulema , Pombo Mercedes 
Published: October 2019

Vincere constituye una mirada oblicua sobrela Italia fascista, una película realizada a partir de la figura de Ida Dalser, amante de Benito Mussolini y madre de su primogénito Benito Albino, nacido en 1915. Tanto Ida como su hijo no figuran generalmente en los libros que recrean los acontecimientos que hacen al fascismo histórico.
Bellocchio los visibiliza mostrando sus vidas trágicas, encerrados hasta su muerte en hospitales psiquiátricos para evitar el conocimiento de una relación extramatrimonial que limitaría al Duce su carrera hacia el poder.
El film constituye una parábola biográfica a través de la cual se explora las marcas y huellas que relacionan la trayectoria individual de Dalser con los orígenes, consolidación y caída del fascismo. Y como todo cine histórico, reconstruye hechos del pasado para abordar el presente de Italia resignificado.
Arte y Transformación social. El aporte de artistas (circenses) en el diseño de políticas culturales urbanas
Authors: Infantino Julieta 
Published: October 2019

En el marco de una diversificación y pluralización del campo de las políticas culturales, desde los años 1990 aunque con mayor intensidad en los 2000 en el contexto Latinoamericano, comienza a desarrollarse un área de propuestas, acciones y políticas culturales que postulan al arte como estrategia para la transformación social. Dicha área se gestó, en gran medida, desde propuestas de colectivos artísticos y experiencias comunitarias que fueron resignificando el “rol social” del arte y las potencialidades del mismo para desarrollar políticas culturales inclusivas. Desde las mismas se propone luchar contra la segregación urbana, la estigmatización de grupos vulnerables y la desigualdad de oportunidades de acceso y participación en la cultura y las artes en el marco de un paradigma de democracia participativa que aboga por la ampliación de derechos (culturales).
En este trabajo propongo analizar el rol de artistas (circenses) –conformados ahora en organizaciones de la sociedad civil y devenidos en activistas, diseñadores/gestores/trabajadores culturales–, en la proposición crítica de alternativas ante paradigmas que han caracterizado a las políticas culturales. Estos paradigmas han instalado, entre otros aspectos, a la cultura como “recurso” para luchar contra los efectos indeseados del neoliberalismo promoviendo la gestión del riesgo social atribuido frecuentemente a los jóvenes pobres urbanos. La intención es analizar opciones que se enfrentan a esta retórica de control de las poblaciones afectadas por el desarrollo neoliberal a través del arte y la cultura y que pregonan el diseño de estrategias redistributivas, ancladas en un paradigma de derechos, que disputen inequidades y garanticen igualdad en el acceso, participación y producción cultural urbana.
ЗОЛОТО-СУЛЬФИДНО-КВАРЦЕВОЕ МЕСТОРОЖДЕНИЕ БАРСУЧИЙ (СЕВЕРО-ВОСТОЧНАЯ ТУВА): МИНЕРАЛОГО-ГЕОХИМИЧЕСКИЕ ОСОБЕННОСТИ И УСЛОВИЯ ОБРАЗОВАНИЯ
Authors: Кужугет Ренат Васильевич , Прокопьев Илья Романович , Редина Анна Андреевна , Анкушева Наталья Николаевна 
Published: October 2019

Золоторудные объекты в скарнах широко распространены в геологических структурах Восточной Тувы, но их промышленная оценка сопряжена со значительными трудностями из-за слабой изученности их минералого-геохимических особенностей. Актуальность исследования обусловлена необходимостью расшифровки генезиса и условий образования золоторудных объектов, локализованных в скарнах. Цель: установление минералого-геохимических особенностей и условий формирования руд месторождения Барсучий в Северо-Восточной Туве. Методы: полевые исследования, детальные минералогические исследования с изучением рудной минерализации в полированных шлифах (аншлифах) с помощью сканирующего электронного микроскопа Tescan Vega 3 sbu с ЭДС Oxford Instruments X-act. Условия формирования минеральных ассоциаций определялись термобарогеохимическими методами. Результаты. Установлено, что золоторудная минерализация на месторождении Барсучий является постскарновой и имеет гидротермальный генезис, образуя прожилково-вкрапленное и прожилковое оруденение штокверкового типа в диоритах, контактовых (роговики, скарны) и гидротермально-метасоматических породах. Околорудные процессы на месторождении выражены в березитизации и лиственитизации кварцевых диоритов, скарнов и карбонатных пород. Отложение самородного золота происходило в две стадии. По составу продуктивных минеральных ассоциаций Барсучий отвечает золото-пирротин-пирит-халькопиритовому типу с калаверитом AuTe2, петцитом Ag3AuTe2, гесситом Ag2Te и минералами ряда теллуровисмутит-теллурантимон. Рудоотложение золота на месторождении происходило из водных растворов с хлоридами Na и K, содержащих CO2 и CH4, с солёностью 1,7−10,5 мас. % NaCl-экв. при изменении окислительно-восстановительного потенциала среды при вариациях f S2, f Se2, f Te2 и снижении температуры рудоносного флюида (первая продуктивная стадия – 360–280 °С, вторая – 320–240 °С). По минералого-геохимическим особенностям месторождение Барсучий относится к малосульфидной золото-сульфидно-кварцевой формации и близко к месторождениям золото-висмутового геохимического типа.
Predictors of clinical outcomes after cardiac resynchronization therapy in patients ≥75 years of age: a retrospective cohort study
Authors: Champ-Rigot Laure , Cornille Anne-Laure , Ollitrault Pierre , Pellissier Arnaud , Chequel Mathieu , Legallois Damien , Milliez Paul 
Published: October 2019

Abstract
Background: Cardiac resynchronization therapy has been shown to benefit selected patients with heart failure and reduced ejection fraction. Older patients have been underrepresented in randomized trials. This study was conducted to determine whether predictive factors for cardiac resynchronization therapy outcomes differ in patients older and younger than 75 years of age.
Methods: Consecutive patients who received a cardiac resynchronization device cardiac resynchronization therapy between 2013 and 2016 in our center were retrospectively included in this cohort study. The primary endpoint was cardiac resynchronization therapy effectiveness, which was defined as survival for one year with both no heart failure hospitalization and improvement by one or more NYHA class. The secondary endpoints were mortality, complications, and device therapies.
Results: Among the 243 patients included, 102 were ≥75 years old. Cardiac resynchronization therapy effectiveness was observed in 70 patients (50%) <75 years old and in 48 patients (47%) ≥75 years old (p=0.69). NYHA class ≥III (OR=6.02; CI95% [1.33-18.77], p=0.002) was a predictive factor for cardiac resynchronization therapy effectiveness only in the ≥75-year-old group, while atrial fibrillation was independently negatively associated with the primary endpoint in the <75-year-old group (OR=0.28; CI95% [0.13-0.62], p=0.001). The one-year mortality rate was 14%, with no difference between age groups. Rescue cardiac resynchronization therapy and atrial fibrillation were independent predictive factors for mortality in both age groups. Eighty-two complications occurred in 45 patients (19%), with no difference between groups. Defibrillator use and QRS duration were independent predictive factors for complications in both age groups. There was no difference between groups considering device therapies.
Conclusion: At one year, cardiac resynchronization therapy response is not compromised by patient age. In older patients, highly symptomatic individuals with NYHA class ≥III have better outcomes after cardiac resynchronization therapy.
Effect of yoga on sleep quality and insomnia in women with sleep problems: a systematic review and meta-analysis
Authors: Wang Weili , Chen Kuang-Huei , Pan Ying-Chieh , Yang Szu-Nian , Chan Yuan-Yu 
Published: October 2019

Abstract
Objectives

To examine the effectiveness and safety of yoga for women with sleep problems by performing a systematic review and meta-analysis.Methods

Medline/PubMed, Clincalkey, ScienceDirect, Embase, PsycINFO, and the Cochrane Library were searched throughout the month of June 2019. Randomized controlled trials comparing yoga groups with control groups in women with sleep problems were included. Two reviewers independently evaluated risk of bias by using the risk of bias tool suggested by the Cochrane Collaboration for programming and conducting systematic reviews and meta-analyses. The main outcome measure was sleep qualityor the severity of insomnia, which was measured using subjective instruments, such as the Pittsburgh Sleep Quality Index (PSQI), Insomnia severity index (ISI), or objective instruments, such as polysomnography, actigraphy, and safety of the intervention. For each outcome, standardized mean difference (SMD) and 95% confidence intervals (CIs) were determined.Results

Nineteen studies including 1832 participants were included in this systematic review. Meta-analyses revealed positive effects of yoga using PSQI or ISI scores in 16 randomized control trials (RCTs) compared with the control group in improving sleep quality in women, PSQI (SMD = −0.54; 95% CI = −0.89 to −0.19 ; P = 0.003). However, three RCTs revealed no effects of yoga compared with the control group in reducing the severity of insomnia in women using ISI (SMD = −0.13; 95% CI = −0.74 to 0.48; P = 0.69). Seven RCTs revealed no evidence for effects of yoga compared with the control group in improving sleep quality for women with breast cancer using PSQI (SMD = −0.15 ; 95% CI = −0.31 to 0.01; P = 0.5). Four RCTs revealed no evidence for the effects of yoga compared with the control group in improving the sleep quality for peri-or postmenopausal women using PSQI (SMD = −0.31; 95% CI = −0.95 to 0.33; P = 0.34).Yoga was not associated with serious adverse events.Discussion

This systematic review and meta-analysis found that yoga intervention in some groups of women was beneficial in managing sleep problems. Despite certain disadvantages in methodology in the included studies, yoga may be recommended as a complementary therapy to women.