bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior chest wall in SAPHO syndrome: magnetic resonance imaging findings
Authors: Yu Meiyan , Cao Yihan , Li Junqiu , Zhang Yanan , Ye Yuqian , Wang Lun , Huang Ziwei , Lu Xinyu , Li Chen , Huo Jianwei 
Published: September 2020

Abstract
Background
The anterior chest wall (ACW) involvement is characteristic of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, yet little research has focused on its magnetic resonance imaging (MRI) findings.

Purpose
To characterize the MRI features of the ACW in patients with SAPHO syndrome.

Methods
Seventy-one patients with SAPHO syndrome and ACW involvement evidenced by bone scintigraphy were recruited in this cross-sectional study. The ACW region was scanned using sagittal, axial, and oblique coronal Dixon T2-weighted sequences and axial Dixon T1-weighted sequences. The characteristics of both active inflammatory and chronic structural lesions were evaluated.

Results
The ACW lesions exhibited an asymmetrical distribution and a predilection for the sternocostoclavicular region (93.0%). Notably, 91.5% of the patients had lesions in the area of the anterior first ribs. Bone marrow edema (BME) was observed in 63 (88.7%) patients, which mainly affected the sternocostal joints (87.3%) and the manubrium sterni (84.5%). All of the BMEs were distributed under the articular surface or the bone cortex, consistent with the distribution of the ligaments and joint capsules. Synovitis was detected in 64 (90.1%) patients, with a predilection for the sternoclavicular joints (76.1%). A soft tissue mass or infiltration was found in all the patients who had bone marrow edema. Thirteen (18.3%) patients showed venous stenosis. Structural changes included bone bridge formation (80.3%), hyperostosis (43.7%), and fat infiltration (39.4%). Four common patterns of involvement were observed: the first rib area, the sternoclavicular area, the sternal angle area, and the areas of the second to sixth sternocostal joints.

Conclusion
The ACW lesions of SAPHO syndrome demonstrated a triad of enthesitis, synovitis, and osteitis, suggesting complex interactions among the ligaments, synovium, and bones in the region. The inflammatory changes in the first rib area were highlighted in SAPHO syndrome.
Loss-of-function maternal-effect mutations of PADI6 are associated with familial and sporadic Beckwith-Wiedemann syndrome with multi-locus imprinting disturbance
Authors: Cubellis Maria Vittoria , Pignata Laura , Verma Ankit , Sparago Angela , Del Prete Rosita , Monticelli Maria , Calzari Luciano , Antona Vincenzo , Melis Daniela , Tenconi Romano , Russo Silvia , Cerrato Flavia , Riccio Andrea 
Published: September 2020

AbstractBackgroundPADI6 is a component of the subcortical maternal complex, a group of proteins that is abundantly expressed in the oocyte cytoplasm, but is required for the correct development of early embryo. Maternal-effect variants of the subcortical maternal complex proteins are associated with heterogeneous diseases, including female infertility, hydatidiform mole, and imprinting disorders with multi-locus imprinting disturbance. While the involvement ofPADI6in infertility is well demonstrated, its role in imprinting disorders is less well established.ResultsWe have identified by whole-exome sequencing analysis four cases of Beckwith-Wiedemann syndrome with multi-locus imprinting disturbance whose mothers are carriers ofPADI6variants. In silico analysis indicates that these variants result in loss of function, and segregation analysis suggests they act as either recessive or dominant-negative maternal-effect mutations. Genome-wide methylation analysis revealed heterogeneous and extensively altered methylation profiles of imprinted loci in the patients, including two affected sisters, but not in their healthy siblings.ConclusionOur results firmly establish the role ofPADI6in imprinting disorders. We report loss-of-function maternal-effect variants ofPADI6that are associated with heterogeneous multi-locus imprinting disturbances in the progeny. The rare finding of two siblings affected by Beckwith-Wiedemann syndrome suggests that in some cases, familial recurrence risk of these variants may be high. However, the heterogeneous phenotypes of the other pedigrees suggest that altered oocytePADI6function results in stochastic maintenance of methylation imprinting with unpredictable consequences on early embryo health.
A study on dynamic aspects variability in the SOLAR educational software ecosystem
Authors: F. Coutinho Emanuel , I. M. Bezerra Carla 
Published: September 2020

AbstractA Software Ecosystem (SECO) refers to a collection of software products with some degree of symbiotic relationship. SOLAR is a Virtual Learning Environment (VLE) that enables the publication of courses and interaction with them among its various users. In this context, SOLAR SECO emerges, where diverse situations of software evolution and maintenance are part of its development process. The aim of this paper is to discuss the dynamic variability of SOLAR educational software ecosystem and software modeling. As an example, dynamic variability aspects of the feature model of SOLAR VLE discussion forum functionality were discussed, one of the most widely used services within SOLAR SECO. As a major conclusion of this work, we identified that the use of the contextual feature diagram allows the study of the dynamic aspects of a system, even more supported by tools to support automatic measurement collection.
Re-calculating the cost of coccidiosis in chickens
Authors: Blake Damer P. , Knox Jolene , Dehaeck Ben , Huntington Ben , Rathinam Thilak , Ravipati Venu , Ayoade Simeon , Gilbert Will , Adebambo Ayotunde O. , Jatau Isa Danladi , Raman Muthusamy , Parker Daniel , Rushton Jonathan , Tomley Fiona M. 
Published: September 2020

AbstractCoccidiosis, caused by Eimeria species parasites, has long been recognised as an economically significant disease of chickens. As the global chicken population continues to grow, and its contribution to food security intensifies, it is increasingly important to assess the impact of diseases that compromise chicken productivity and welfare. In 1999, Williams published one of the most comprehensive estimates for the cost of coccidiosis in chickens, featuring a compartmentalised model for the costs of prophylaxis, treatment and losses, indicating a total cost in excess of £38 million in the United Kingdom (UK) in 1995. In the 25 years since this analysis the global chicken population has doubled and systems of chicken meat and egg production have advanced through improved nutrition, husbandry and selective breeding of chickens, and wider use of anticoccidial vaccines. Using data from industry representatives including veterinarians, farmers, production and health experts, we have updated the Williams model and estimate that coccidiosis in chickens cost the UK £99.2 million in 2016 (range £73.0–£125.5 million). Applying the model to data from Brazil, Egypt, Guatemala, India, New Zealand, Nigeria and the United States resulted in estimates that, when extrapolated by geographical region, indicate a global cost of ~ £10.4 billion at 2016 prices (£7.7–£13.0 billion), equivalent to £0.16/chicken produced. Understanding the economic costs of livestock diseases can be advantageous, providing baselines to evaluate the impact of different husbandry systems and interventions. The updated cost of coccidiosis in chickens will inform debates on the value of chemoprophylaxis and development of novel anticoccidial vaccines.
Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit
Authors: Timsit Jean-François , Baleine Julien , Bernard Louis , Calvino-Gunther Silvia , Darmon Michael , Dellamonica Jean , Desruennes Eric , Leone Marc , Lepape Alain , Leroy Olivier , Lucet Jean-Christophe , Merchaoui Zied , Mimoz Olivier , Misset Benoit , Parienti Jean-Jacques , Quenot Jean-Pierre , Roch Antoine , Schmidt Matthieu , Slama Michel , Souweine Bertrand , Zahar Jean-Ralph , Zingg Walter , Bodet-Contentin Laetitia , Maxime Virginie 
Published: September 2020

AbstractThe French Society of Intensive Care Medicine (SRLF), jointly with the French-Speaking Group of Paediatric Emergency Rooms and Intensive Care Units (GFRUP) and the French-Speaking Association of Paediatric Surgical Intensivists (ADARPEF), worked out guidelines for the management of central venous catheters (CVC), arterial catheters and dialysis catheters in intensive care unit. For adult patients: Using GRADE methodology, 36 recommendations for an improved catheter management were produced by the 22 experts. Recommendations regarding catheter-related infections’ prevention included the preferential use of subclavian central vein (GRADE 1), a one-step skin disinfection(GRADE 1) using 2% chlorhexidine (CHG)-alcohol (GRADE 1), and the implementation of a quality of care improvement program. Antiseptic- or antibiotic-impregnated CVC should likely not be used (GRADE 2, for children and adults). Catheter dressings should likely not be changed before the 7th day, except when the dressing gets detached, soiled or impregnated with blood (GRADE 2− adults). CHG dressings should likely be used (GRADE 2+). For adults and children, ultrasound guidance should be used to reduce mechanical complications in case of internal jugular access (GRADE 1), subclavian access (Grade 2) and femoral venous, arterial radial and femoral access (Expert opinion). For children, an ultrasound-guided supraclavicular approach of the brachiocephalic vein was recommended to reduce the number of attempts for cannulation and mechanical complications. Based on scarce publications on diagnostic and therapeutic strategies and on their experience (expert opinion), the panel proposed definitions, and therapeutic strategies.
SEIR epidemic model for COVID-19 transmission by Caputo derivative of fractional order
Authors: Rezapour Shahram , Mohammadi Hakimeh , Samei Mohammad Esmael 
Published: September 2020

AbstractWe provide a SEIR epidemic model for the spread of COVID-19 using the Caputo fractional derivative. The feasibility region of the system and equilibrium points are calculated and the stability of the equilibrium points is investigated. We prove the existence of a unique solution for the model by using fixed point theory. Using the fractional Euler method, we get an approximate solution to the model. To predict the transmission of COVID-19 in Iran and in the world, we provide a numerical simulation based on real data.
Long non-coding RNA MIR4300HG polymorphisms are associated with postoperative nausea and vomiting: a genome-wide association study
Authors: Sugino Shigekazu , Konno Daisuke , Kawai Yosuke , Nagasaki Masao , Endo Yasuhiro , Hayase Tomo , Yamazaki-Higuchi Misako , Kumeta Yukihiro , Tachibana Shunsuke , Saito Katsuhiko , Suzuki Jun , Kido Kanta , Kurosawa Nahoko , Namiki Akiyoshi , Yamauchi Masanori 
Published: September 2020

Abstract
Background
Genetic factors such as single-nucleotide polymorphisms (SNPs) play a key role in the development of postoperative nausea and vomiting (PONV). However, previous findings are not widely applicable to different populations because of population-specific genetic variation. We developed a Japanese-specific DNA microarray for high-throughput genotyping. The aim of the current study was to identify SNPs associated with PONV on a genome-wide scale using this microarray in a sample of Japanese surgical patients.

Methods
Associations between 659,636 SNPs and the incidence of PONV 24 h after surgery in a limited sample of 24 female patients were assessed using the microarray. After imputation of genotypes at 24,330,529 SNPs, 78 SNPs were found to be associated with the incidence of PONV. We chose 4 of the 78 SNPs to focus on by in silico functional annotation. Finally, we genotyped these 4 candidate SNPs in 255 patients using real-time PCR to verify association with the incidence of PONV.

Results
The T > C variant of rs11232965 in the long non-coding RNA MIR4300HG was significantly associated with reduced incidence of PONV among genotypes and between alleles (p = 0.01 and 0.007).

Conclusions
We identified a novel SNP (rs11232965) in the long non-coding RNA MIR4300HG that is associated with PONV. The rs11232965-SNP variant (T > C) is protective against the incidence of PONV.

Trial registration
This study was registered at the UMIN Clinical Trials Registry (Identifier: UMIN000022903, date of registration: June 27, 2016, retrospectively registered.
Incidence and predictors of loss to follow-up among HIV-positive adults in northwest Ethiopia: a retrospective cohort study
Authors: Birhanu Molla Yigzaw , Leshargie Cheru Tesema , Alebel Animut , Wagnew Fasil , Siferih Melkamu , Gebre Tsige , Kibret Getiye Dejenu 
Published: September 2020

Abstract
Background
Despite the rapid expansion of antiretroviral therapy services, ‘loss to follow-up’ is a significant public health concern globally. Loss to follow-up of individuals from ART has a countless negative impact on the treatment outcomes. There is, however, limited information about the incidence and predictors of loss to follow-up in our study area. Thus, this study aimed to determine the incidence rate and predictors of loss to follow-up among adult HIV patients on ART.

Methods
A retrospective cohort study was undertaken using 484 HIV patients between January 30, 2008, and January 26, 2018, at Debre Markos Referral Hospital. All eligible HIV patients who fulfilled the inclusion criteria were included in this study. Data were entered into Epi-data Version 4.2 and analyzed using STATATM Version 14.0 software. The Nelson-Aalen cumulative hazard estimator was used to estimate the hazard rate of loss to follow-up, and the log-rank test was used to compare the survival curve between different categorical variables. Both bivariable and multivariable Cox-proportional hazard regression models were fitted to identify predictors of LTFU.

Results
Among a cohort of 484 HIV patients at Debre Markos Referral Hospital, 84 (17.36%) were loss their ART follow-up. The overall incidence rate of loss to follow-up was 3.7 (95% CI 3.0, 5.0) per 100 adult-years. The total LTFU free time of the participants was 2294.8 person-years. In multivariable Cox-regression analysis, WHO stage IV (AHR 2.8; 95% CI 1.2, 6.2), having no cell phone (AHR 1.9; 95% CI 1.1, 3.4), and rural residence (AHR 0.6; 95% CI 0.37, 0.99) were significant predictors of loss to follow-up.

Conclusion
The incidence of loss to ART follow-up in this study was low. Having no cell phone and WHO clinical stage IV were causative predictors, and rural residence was the only protective factor of loss to follow-up. Therefore, available intervention modalities should be strengthened to mitigate loss to follow-up by addressing the identified risk factors.
When Ignorance Is Not Bliss: An Empirical Analysis of Subtier Supply Network Structure on Firm Risk
Authors: Wang Yixin (Iris) , Li Jun , Wu Di (Andrew) , Anupindi Ravi 
Published: September 2020

Using a multitier mapping of supply-chain relationships constructed from granular global, firm-to-firm supplier–customer linkages data, we quantify the degree of financial risk propagation from the supply network beyond firms’ direct supply-chain connections and isolate structural network properties serving as significant moderators of risk propagation. We first document a baseline fact: a significant proportion of tier-2 suppliers are shared by tier-1 suppliers. We then construct two simple metrics to capture the degree of tier-2 sharing and disentangle its effect from tier-2 suppliers’ own risks. We show that the focal firms’ risk levels are significantly related to the proportion of shared tier-2 suppliers in their supply network, and the effect becomes monotonically stronger as their tier-2 suppliers become more highly shared. Finally, we uncover causal relationships behind these associations using a new source of exogenous, idiosyncratic risk events in an event study setting. We show that, as tier-2 suppliers are impacted by these events, focal firms experience negative abnormal returns, the magnitude of which is significantly larger when the impacted tier-2 suppliers are more heavily shared. Overall, our study uncovers the subtier network structure as an important risk source for the focal firm, with the degree of tier-2 sharing as the main moderator. Our results also provide the microfoundation for a common structure in idiosyncratic risks and suggest the importance of incorporating the effect of subtier supply network structure in the portfolio-optimization process. This paper was accepted by Vishal Gaur, operations management.
Use of bromelain in cutaneous wound healing in streptozocin-induced diabetic rats: an experimental model
Authors: Fathi Amene Nikgoftar , Sakhaie Mohammad Hassan , Babaei Sepehr , Babaei Soroush , Slimabad Fateme , Babaei Saeid 
Published: September 2020

Objective:To assess the effect of bromelain on different aspects of the wound healing process in type 1 diabetic rats.Method:In this study, 112 streptozocin-diabetic (type 1) male Wistar rats were euthanised; 28 each on days three, five, seven and 15, after a wound incision had been made. To estimate changes in a number of different cellular and tissue elements, histological sections were provided from all wound areas and stained with haematoxylin and eosin. Some 1.056mm2of total wound area from all specimens were evaluated, by assessment of 4200 microscope photos provided from all histological sections, by stereological methods. A biomechanical test of each wound area was performed with an extensometer to evaluate the work-up to maximum force and maximum stress of the healed wound on day 15.Results:In the experimental groups, bromleain caused significant wound contraction and reduced granulation tissue formation by day 7 (p=0.003); increased neovasculars (new small vessels that appear in the wound area during wound healing) on days three, five and seven (p=0.001); significantly increased fibroblasts on day five but decreased by day seven (p=0.002); and significantly decreased macrophage numbers and epithelium thickness on all days of study (p=0.005). Wound strength significantly increased in experimental groups by day 15.Conclusion:Bromelain has a wide range of therapeutic benefits, but in most studies the mode of its action is not properly understood. It has been proved that bromelain has no major side effects, even after prolonged use. According to the results of this study, bromelain can be used as an effective health supplement to promote and accelerate wound healing indices, reduce inflammation and improve biomechanical parameters in diabetic wounds.
Designing high-performance nighttime thermoradiative systems for harvesting energy from outer space
Authors: Zhang Xin , Du Jianying , Chen Jincan , Ang Lay Kee , Ang Yee Sin 
Published: September 2020

Energy harvesting using thermoradiative systems has been extensively explored in recent years as a novel strategy for further reducing our energy footprint. However, the nighttime application, thermodynamic limit, and optimal design of such a system remain largely unaddressed so far. Here we propose an improved nighttime thermoradiative system (NTS) for electrical power generation by optically coupling Earth’s surface with outer space. Our theoretical model predicts that the NTS operating with Earth (deep space) at 300 K (3 K) yields a maximum power density of

12.3

W
m

−
2

with an efficiency limit of 18.5%, which is potentially more advantageous than previous nighttime energy harvesting systems, such as a nighttime thermoelectric generator. We find that optimizing the thickness of the active layer, enhancing thermal infrared emission, and employing a silver backreflector for photon recycling are crucially important in improving system performance. This Letter provides new insights for the optimal designs of NTSs and paves the way toward practical nighttime power generation.
Megahertz-rate OH planar laser-induced fluorescence imaging in a rotating detonation combustor
Authors: Hsu Paul S. , Slipchenko Mikhail N. , Jiang Naibo , Fugger Christopher A. , Webb Austin M. , Athmanathan Venkat , Meyer Terrence R. , Roy Sukesh 
Published: September 2020

Megahertz-rate hydroxyl radical planar laser-induced fluorescence (OH-PLIF) was demonstrated in a hydrogen/air rotating detonation combustor for the first time, to the best of our knowledge. A custom injection-seeded optical parametric oscillator (OPO) pumped by the 355 nm output of a high-energy burst-mode laser produced narrowband pulses near 284 nm for OH excitation. The system generated sequences of more than 150 ultraviolet pulses with 400 µJ/pulse at 1 MHz and 150 µJ/pulse at 2 MHz. The order of magnitude improvement in the repetition rate over prior OH-PLIF measurements and in the number of pulses over previous megahertz burst-mode OPOs enables spatiotemporal analysis of complex detonation combustion dynamics.
Extrinsic optical activity in all-dielectric terahertz metamaterial
Authors: Yang Shijun , Li Yanfeng , Chen Xieyu , Yang Quanlong , Han Jiaguang , Zhang Weili 
Published: September 2020

Chiral metamaterials have attracted wide interest because strong optical activity at designed frequencies could be achieved beyond that in natural materials. Here we propose an all-dielectric metamaterial with strong extrinsic circular dichroism and circular birefringence by periodically arranging symmetry-broken dielectric Mie resonators at terahertz frequencies. The strong interaction between the electric and magnetic resonances from circularly polarized incident waves dominates the performance of the all-dielectric metamaterial, which exhibits a 60% circular dichroism in transmission and a polarization rotation angle of 60° at maximum, respectively. Additionally, the spectral range of the circular dichroism with preserved amplitude can be adjusted continuously in the frequency range from 0.67–0.79 THz by tuning the tilt angle of the incident wave. Our findings will be of great potential in polarization control applications such as asymmetric transmission, optical isolation, and on-chip chiral manipulation.
Efficient, sub-4-cycle, 1-µm-pumped optical parametric amplifier at 10  µm based on BaGa4S7
Authors: Heiner Zsuzsanna , Petrov Valentin , Mero Mark 
Published: September 2020

We report on a microjoule-scale mid-infrared optical parametric amplifier (OPA) based on the recently developed wide-bandgap orthorhombic crystal,

B
a
G

a

4

S

7

(BGS) and directly compare its performance to that of

L
i
G
a

S

2

(LGS) in the same OPA setup. The source is based on a single OPA stage amplifying supercontinuum seed pulses with a quantum efficiency of 29% at an idler wavelength of 10 µm, featuring nominally carrier-envelope phase-stable pulses. As a result of pumping the OPA directly at 1 µm, the overall conversion efficiency far exceeds that of traditional schemes based on OPAs followed by difference frequency generation. Chirp compensation using bulk germanium resulted in 126 fs pulses covering the 7.6–11.5 µm spectral range. BGS holds great promise for power scaling due to its availability in larger single-crystal sizes than LGS.