bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equatorial Circulation in the Western Indian Ocean During Onset of the 2018 Summer Monsoon and Links to the Bay of Bengal
Authors: Todd Robert E. 
Published: February 2020

AbstractCross‐equator transects occupied by an underwater glider and a research vessel in the western Indian Ocean captured the evolution of equatorial circulation during onset of the boreal summer monsoon in 2018. At the end of the winter monsoon in March, surface currents were westward, while the equatorial undercurrent carried salty Arabian Sea High‐Salinity Water eastward. As winds transitioned from westward to eastward during April, an eastward near‐surface Wyrtki Jet developed, while the equatorial undercurrent weakened, vanishing by May. A first‐mode baroclinic Kelvin wave propagated through the survey region after westward winds relaxed. However, the vertical structure of the evolving circulation was inconsistent with the first baroclinic mode, suggesting the influence of higher modes in setting observed vertical structure. The strong equatorial undercurrent at the end of the winter monsoon allowed high‐salinity waters from the western equatorial Indian Ocean to reach the southern Bay of Bengal in summer 2018.
Comparative genome-centric analysis reveals seasonal variation in the function of coral reef microbiomes
Authors: Glasl Bettina , Robbins Steven , Frade Pedro R , Marangon Emma , Laffy Patrick W , Bourne David G , Webster Nicole S 
Published: March 2020

Abstract
Microbially mediated processes contribute to coral reef resilience yet, despite extensive characterisation of microbial community variation following environmental perturbation, the effect on microbiome function is poorly understood. We undertook metagenomic sequencing of sponge, macroalgae and seawater microbiomes from a macroalgae-dominated inshore coral reef to define their functional potential and evaluate seasonal shifts in microbially mediated processes. In total, 125 high-quality metagenome-assembled genomes were reconstructed, spanning 15 bacterial and 3 archaeal phyla. Multivariate analysis of the genomes relative abundance revealed changes in the functional potential of reef microbiomes in relation to seasonal environmental fluctuations (e.g. macroalgae biomass, temperature). For example, a shift from Alphaproteobacteria to Bacteroidota-dominated seawater microbiomes occurred during summer, resulting in an increased genomic potential to degrade macroalgal-derived polysaccharides. An 85% reduction of Chloroflexota was observed in the sponge microbiome during summer, with potential consequences for nutrition, waste product removal, and detoxification in the sponge holobiont. A shift in the Firmicutes:Bacteroidota ratio was detected on macroalgae over summer with potential implications for polysaccharide degradation in macroalgal microbiomes. These results highlight that seasonal shifts in the dominant microbial taxa alter the functional repertoire of host-associated and seawater microbiomes, and highlight how environmental perturbation can affect microbially mediated processes in coral reef ecosystems.
Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration
Authors: Li Rui , Li Duo-hui , Zhang Hong-yu , Wang Jian , Li Xiao-kun , Xiao Jian 
Published: March 2020

AbstractPeripheral nerve injury (PNI), one of the most common concerns following trauma, can result in a significant loss of sensory or motor function. Restoration of the injured nerves requires a complex cellular and molecular response to rebuild the functional axons so that they can accurately connect with their original targets. However, there is no optimized therapy for complete recovery after PNI. Supplementation with exogenous growth factors (GFs) is an emerging and versatile therapeutic strategy for promoting nerve regeneration and functional recovery. GFs activate the downstream targets of various signaling cascades through binding with their corresponding receptors to exert their multiple effects on neurorestoration and tissue regeneration. However, the simple administration of GFs is insufficient for reconstructing PNI due to their short half‑life and rapid deactivation in body fluids. To overcome these shortcomings, several nerve conduits derived from biological tissue or synthetic materials have been developed. Their good biocompatibility and biofunctionality made them a suitable vehicle for the delivery of multiple GFs to support peripheral nerve regeneration. After repairing nerve defects, the controlled release of GFs from the conduit structures is able to continuously improve axonal regeneration and functional outcome. Thus, therapies with growth factor (GF) delivery systems have received increasing attention in recent years. Here, we mainly review the therapeutic capacity of GFs and their incorporation into nerve guides for repairing PNI. In addition, the possible receptors and signaling mechanisms of the GF family exerting their biological effects are also emphasized.
Tumor-educated B cells promote renal cancer metastasis via inducing the IL-1β/HIF-2α/Notch1 signals
Authors: Li Saiyang , Huang Chi , Hu Guanghui , Ma Junjie , Chen Yonghui , Zhang Jin , Huang Yiran , Zheng Junhua , Xue Wei , Xu Yunfei , Zhai Wei 
Published: March 2020

AbstractWhile B cells in the tumor microenvironment (TME) might play important roles in cancer progression, their impacts on the renal cell carcinoma (RCC) metastasis remained unclear, which drew our attention to further explore. We found that RCC tissues could recruit more B cells than the surrounding normal renal tissues from human clinical RCC samples. Wound healing assay, transwell assay and 3D invasion assays demonstrated that recruited B cells, also known as tumor-educated B cells (TEB), could significantly increase the RCC cell migration and invasion. In addition, in vivo data from xenograft RCC mouse model also confirmed that TEB could enhance RCC cell invasive and metastatic capability. Mechanism dissection revealed that TEB activated IL-1β/HIF-2α signals in RCC cells that could induce the downstream Notch1 signaling pathway. The above results demonstrated the key roles of TEB within renal cancer associated tumor microenvironment were metastasis-promotor and might help us to develop the potential therapies via targeting these newly identified IL-1β/HIF-2α/Notch1 signals in RCC progression.
Resveratrol alleviates obesity-induced skeletal muscle inflammation via decreasing M1 macrophage polarization and increasing the regulatory T cell population
Authors: Shabani Maryam , Sadeghi Asie , Hosseini Hossein , Teimouri Maryam , Babaei Khorzoughi Reyhaneh , Pasalar Parvin , Meshkani Reza 
Published: March 2020

AbstractResveratrol was reported to inhibit inflammatory responses; however, the role of this polyphenol in obesity-induced skeletal muscle inflammation remains unknown. Mice fed a high fat diet (HFD) were treated with resveratrol for 16 weeks. Resveratrol treatment decreased macrophage infiltration into skeletal muscle of HFD-fed mice. Resveratrol also led to the polarization of macrophages to the M2 direction, as well as decreasing the expression of a number of M1 pro-inflammatory cytokines [tumor necrosis factor α (TNF-α), interleukin 1 β (IL-1β) and interleukin 6 (IL-6)]. In addition, increased infiltration of regulatory T cells (Treg cells) was found following resveratrol treatment in skeletal muscle of mice. Decreased intramyocellular lipid deposition was associated with reduced expression levels of toll-like receptors 2 (TLR2) and TLR4 in resveratrol treated mice. We also found that diminished inflammation in skeletal muscle following resveratrol treatment was accompanied by increasing phosphorylation of 5’-adenosine monophosphate-activated protein kinase (AMPK) and decreasing phosphorylation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK). Taken together, these findings suggest that resveratrol ameliorates inflammation in skeletal muscle of HFD-induced model of obesity. Therefore, resveratrol might represent a potential treatment for attenuation of inflammation in skeletal muscle tissue.
Emotion Perception in Hadza Hunter-Gatherers
Authors: Gendron Maria , Hoemann Katie , Crittenden Alyssa N. , Mangola Shani Msafiri , Ruark Gregory A. , Barrett Lisa Feldman 
Published: March 2020

AbstractIt has long been claimed that certain configurations of facial movements are universally recognized as emotional expressions because they evolved to signal emotional information in situations that posed fitness challenges for our hunting and gathering hominin ancestors. Experiments from the last decade have called this particular evolutionary hypothesis into doubt by studying emotion perception in a wider sample of small-scale societies with discovery-based research methods. We replicate these newer findings in the Hadza of Northern Tanzania; the Hadza are semi-nomadic hunters and gatherers who live in tight-knit social units and collect wild foods for a large portion of their diet, making them a particularly relevant population for testing evolutionary hypotheses about emotion. Across two studies, we found little evidence of universal emotion perception. Rather, our findings are consistent with the hypothesis that people infer emotional meaning in facial movements using emotion knowledge embrained by cultural learning.
The response relevance of visual stimuli modulates the P3 component and the underlying sensorimotor network
Authors: Asanowicz Dariusz , Gociewicz Krzysztof , Koculak Marcin , Finc Karolina , Bonna Kamil , Cleeremans Axel , Binder Marek 
Published: March 2020

AbstractThe functional meaning and neural basis of the P3b component of ERPs are still under debate. One of the main issues is whether P3b reflects only stimulus-related processes (stimulus evaluation hypothesis) or response-related processes as well (stimulus-response or S-R link activation hypothesis). Here, we conducted an EEG experiment examining whether P3b may indeed reflect an S-R link activation, followed by an fMRI experiment in which we explored the brain areas and functional connectivity possibly constituting the neural basis of these sensorimotor links. In both experiments, two successive visual stimuli, S1 and S2, were presented with a 1 sec interval, and responses were defined either by S1 or S2, while participants responded only after S2 onset. The obtained EEG results suggest that P3b may be interpreted in terms of the S-R link activation account, although further studies are needed to disentangle P3-related activity from overlapping anticipatory activity. The obtained fMRI results showed that processing of the relevant S1 involved activation of a distributed postero-anterior sensorimotor network, and increased strength of functional connectivity within this network. This network may underlie activation of the S-R links, thus possibly also the P3b component, forming a bridging step between sensory encoding and response execution.
Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
Authors: Mendham Amy E. , Larsen Steen , George Cindy , Adams Kevin , Hauksson Jon , Olsson Tommy , Fortuin-de Smidt Melony C. , Nono Nankam Pamela A. , Hakim Olah , Goff Louise M. , Pheiffer Carmen , Goedecke Julia H. 
Published: March 2020

AbstractWe assessed differences in mitochondrial function in gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise training; and examined depot-specific associations with body fat distribution and insulin sensitivity (SI). Obese, black South African women (n = 45) were randomized into exercise (n = 23) or control (n = 22) groups. Exercise group completed 12-weeks of aerobic and resistance training (n = 20), while the control group (n = 15) continued usual behaviours. Mitochondrial function (high-resolution respirometry and fluorometry) in gSAT and aSAT, SI (frequently sampled intravenous glucose tolerance test), body composition (dual-energy X-ray absorptiometry), and ectopic fat (MRI) were assessed pre- and post-intervention. At baseline, gSAT had higher mitochondrial respiratory capacity and hydrogen peroxide (H2O2) production than aSAT (p < 0.05). Higher gSAT respiration was associated with higher gynoid fat (p < 0.05). Higher gSAT H2O2 production and lower aSAT mitochondrial respiration were independently associated with lower SI (p < 0.05). In response to training, SI improved and gynoid fat decreased (p < 0.05), while H2O2 production reduced in both depots, and mtDNA decreased in gSAT (p < 0.05). Mitochondrial respiration increased in aSAT and correlated with a decrease in body fat and an increase in soleus and hepatic fat content (p < 0.05). This study highlights the importance of understanding the differences in mitochondrial function in multiple SAT depots when investigating the pathophysiology of insulin resistance and associated risk factors such as body fat distribution and ectopic lipid deposition. Furthermore, we highlight the benefits of exercise training in stimulating positive adaptations in mitochondrial function in gluteal and abdominal SAT depots.
Kibi Plateau: A stable-coherent tectonic unit in the active Japanese Islands
Authors: Sonehara Takafumi , Yagi Koshi , Takeshita Hiroyuki , Aoki Kazumasa , Aoki Shogo , Otofuji Yo-ichiro , Itaya Tetsumaru 
Published: March 2020

AbstractThe Kibi Plateau in the active Japanese Islands consists of mainly Permian to Cretaceous rocks that have been deeply weathered into a red soil, comprising a peneplain with U-shaped valley. Systematic geological analyses of the Eocene fluvial deposits revealed the paleo-rivers that existed in the eastern Asian continent and streamed out to the paleo-Pacific Ocean. Each paleo-river is traced in a flow line shape without any significant vertical and horizontal displacement. The Eocene shallow marine sediments in a possible coastal region have no relevant inclination. These geological data strongly suggest that the Kibi Plateau has been a stable-coherent tectonic unit since the Eocene through the opening of the Japan Sea and the associated quick rotation of SW Japan in the Middle Miocene. The Kibi Plateau region with a thick crust over 30 km existed as a stable eastern segment of the Asian continent in the Eocene. The Kibi Plateau tectonic unit drifted to the south without any destruction due to the peripheral successive tectonic events such as the Philippine Sea plate subduction and the reactivation of Median Tectonic Line. No subduction related arc volcanism since the Eocene has also influenced to preserve the stable tectonic unit.
Introduced non-native mangroves express better growth performance than co-occurring native mangroves
Authors: Fazlioglu Fatih , Chen Luzhen 
Published: March 2020

AbstractMangroves are salt-tolerant woody species occurring in tropical/subtropical coastal habitats. Plantation of fast-growing non-native mangrove species has been used as a tool for mangrove restoration/reforestation in several countries. However, the fast-growth ability can make recently introduced species invasive as they can possibly replace co-occurring native mangroves through expressing higher growth performance and phenotypic plasticity. Therefore, quantifying growth differences between native versus non-native mangrove species is important for forest ecology and management. In this meta-analysis, we compared the growth performance of non-native and native mangrove species pairs by analysing all available results in the literature (33 studies). We found that non-native mangrove species performed better than co-occurring native mangrove species in their introduced regions (Log response ratio = 0.51 ± 0.05) and they also expressed higher trait plasticity. Therefore, these species can be potentially invasive owing to their greater competitive advantage. However, the growth difference was diminished at higher latitudes where native mangrove species seem to perform as well as non-native mangrove species do. This is the first meta-analysis on the growth response of mangroves and it has consequential management implications. We suggest that planting of non-native mangrove species should be avoided and their spread should be monitored.
Identification of serum biomarkers for active pulmonary tuberculosis using a targeted metabolomics approach
Authors: Cho Yonggeun , Park Youngmok , Sim Bora , Kim Jungho , Lee Hyejon , Cho Sang-Nae , Kang Young Ae , Lee Sang-Guk 
Published: March 2020

AbstractAlthough tuberculosis (TB) is a severe health problem worldwide, the current diagnostic methods are far from optimal. Metabolomics is increasingly being used in the study of infectious diseases. We performed metabolome profiling to identify potential biomarkers in patients with active TB. Serum samples from 21 patients with active pulmonary TB, 20 subjects with latent TB infection (LTBI), and 28 healthy controls were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) followed by multivariate and univariate analyses. Metabolic profiles indicated higher serum levels of glutamate, sulfoxy methionine, and aspartate and lower serum levels of glutamine, methionine, and asparagine in active TB patients than in LTBI subjects or healthy controls. The ratios between metabolically related partners (glutamate/glutamine, sulfoxy methionine/methionine, and aspartate/asparagine) were also elevated in the active TB group. There was no significant difference in the serum concentration of these metabolites according to the disease extent or risk of relapse in active TB patients. Novel serum biomarkers such as glutamate, sulfoxy methionine, aspartate, glutamine, methionine, and asparagine are potentially useful for adjunctive, rapid, and noninvasive pulmonary TB diagnosis.
Does resistance training have an effect on levels of ferritin and atherogenic lipids in postmenopausal women? – A pilot trial
Authors: Ward Liam J. , Hammar Mats , Lindh-Åstrand Lotta , Berin Emilia , Lindblom Hanna , Rubér Marie , Spetz Holm Anna-Clara , Li Wei 
Published: March 2020

AbstractThe objective of this study was to determine if 15 weeks of resistance training (RT) can alter the levels of blood lipids, body iron status, and oxidative stress in postmenopausal women with vasomotor symptoms. Postmenopausal women enrolled in a randomised controlled trial were allocated to either a sedentary control group (n = 29) or a RT group (n = 26). Blood samples were taken at week-0 and week-15 for all participants. Blood lipids and iron status were measured via routine clinical analyses. Immunoassays were used to measure oxidative stress markers. The RT group, with good compliance, was associated with significant reductions in ferritin, total cholesterol, low-density lipoprotein, and non-high-density lipoprotein cholesterol. Moreover, ferritin was positively correlated with atherogenic lipids while negatively correlated with high-density lipoprotein in RT women. This occurred without alterations in serum iron, transferrin, transferrin-saturation, C-reactive protein and oxidative stress markers. No differences were found in control women. This study suggests that RT in postmenopausal women both reduces levels of ferritin and counteracts atherogenic lipid profiles independent of an apparent oxidative mechanism. RT may be a beneficial intervention in postmenopausal women via an interaction between ferritin and lipids; however, further investigation in a larger cohort is essential.
Monomineralic anorthosites in layered intrusions are indicators of the magma chamber replenishment by plagioclase-only-saturated melts
Authors: Latypov Rais , Chistyakova Sofya , Costin Gelu , Namur Olivier , Barnes Steve , Kruger Willem 
Published: March 2020

AbstractThe formation of some Earth’s monomineralic igneous rocks appears to be prohibited by constraints imposed by liquidus phase-equilibria on evolution of mantle-derived magmas. Yet, these rocks exist as stratiform layers in many mafic-ultramafic intrusions. One conspicuous example is monomineralic anorthosites in the Bushveld Complex that occur as stratiform layers up to hundreds of kilometres in length. Such monomineralic anorthosites appear to require parental melts saturated in plagioclase only but where and how to produce these melts remains a contentious issue. Here we argue that they are likely sourced from deep-seated magma reservoirs. In response to pressure reduction, these ascending melts become first superheated and then saturated in plagioclase after stalling and cooling in shallow-level chambers. Adcumulus growth of plagioclase from such melts at the chamber floor results in the formation of monomineralic anorthosites. We propose that stratiform layers of monomineralic anorthosites in layered intrusions are products of the chamber replenishment by melts whose saturation in plagioclase as a single liquidus phase is triggered by their transcrustal ascent towards the Earth’s surface.
Interactions of impulsivity, general executive functions, and specific inhibitory control explain symptoms of social-networks-use disorder: An experimental study
Authors: Wegmann Elisa , Müller Silke M. , Turel Ofir , Brand Matthias 
Published: March 2020

AbstractWhile the use of social media and online-communication applications has become an integral part of everyday life, some individuals suffer from an excessive, uncontrolled use of social media despite experiencing negative consequences. In accordance with neuropsychological models of addiction, we assume the tendency of a social-networks-use disorder to be related to an interplay of predisposing personality traits (e.g., impulsivity), and reductions in cognitive functions (e.g., executive functions, inhibitory control). The current study makes first strides towards examining this interplay. In addition to a newly developed social-networks-specific auditory Go-NoGo paradigm, other neuropsychological paradigms were used. Impulsivity and social-networks-use-disorder symptoms were assessed by standardized questionnaires. The results show that the symptom severity of a social-networks-use disorder is mainly associated with attentional impulsivity. General executive functions and specific inhibitory control of social-networks-related cues have no direct effect on symptom severity. However, moderated regression analyses emphasize that increased symptom severity is associated with higher attentional impulsivity, especially if there are additionally reductions in executive functions or specific inhibitory control. The results complement previous findings and inform future research on social-networks-use disorder. The findings support the applicability of theoretical models of addictive behaviors to the social-networks-use disorder and point to social-networks-related specificities regarding attention-related facets.