bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective evaluation of systemic and/or topical pilocarpine treatment for canine neurogenic dry eye: 11 cases
Authors: Wegg Michaela L. 
Published: December 2019

AbstractObjectiveTo assess the response to topical and/or systemic pilocarpine in dogs with neurogenic dry eye.MethodMedical records of dogs diagnosed with dry eye between 2015 and 2018 were reviewed. Cases were excluded if STT values were decreased bilaterally, if dogs were lost to follow‐up, or if surgical measures (parotid duct transposition) were undertaken within thirty days of presentation. Dogs were on treatment with topical pilocarpine (0.1%, every 6 hours) and/or oral pilocarpine (starting dose 2%, one drop per 10 kg every twelve hours).ResultsEleven cases were included in the study, seven females and four males with mean age of 10 years. Seven cases had xeromycteria, two cases had facial nerve paralysis, and one case had Horner's syndrome. Seven cases (63.6%) had successful outcome following pilocarpine treatment, return to normal STT (15‐25mm/minute), in an average of 24 ± 5.1 days. Of these cases, five had both systemic and topical treatment, one had just topical treatment, and one had just systemic treatment. The average time to normal tear production on treatment with topical pilocarpine ± systemic was 23 days (range 9‐48 days). The number of systemic drops until a positive response varied between individuals from 0.8drops/10kg to 7drops/10kg.ConclusionPilocarpine treatment (topical ± systemic) is an effective therapy for unilateral dry eye disease in cases suspected to be neurogenic in origin. Most cases responded within 30 days. Side effects included topical irritation to the ophthalmic solution and systemic effects from oral pilocarpine, such as diarrhea and regurgitation.
Biocompatibility of allogenic canine fascia lata: In vitro evaluation and small case series
Authors: El‐Taliawi Omar G. , Taguchi Takashi , Dong Fanglong , Battig Jean , Griffon Dominique J. 
Published: December 2019

AbstractObjectiveTo evaluate the biocompatibility of canine fascia lata (FL) in vitro and after FL allograft implantation in dogs with clinical disease.Study designIn vitro experiment and small case series.Sample populationSix dogs treated with allogenic freeze‐dried FL.MethodsFibroblasts were cultured on disks of FL, polypropylene mesh (PM; negative control), and porcine small intestinal submucosa (SIS; positive control). Constructs were compared at 3, 7, and 14 days for water content, DNA amounts, scanning electron microscopy, and histology.Records of dogs treated with FL allografts with follow‐up examination were reviewed for signalment, indication for surgery, surgical procedure, and outcomes. All owners were invited to complete a standardized questionnaire for long‐term follow‐up.ResultsWater content was greater in FL and SIS than in PM (P= .03). Fascia lata constructs contained more DNA compared with PM constructs at days 7 and 14 (P < .05), whereas SIS constructs did not differ from FL or PM. Fibroblasts appeared spherical and distributed throughout FL constructs, whereas they appeared stellate and remained on the surface of SIS and PM. Fascia lata allografts were implanted in six dogs with surgical conditions. No incisional complications were noted. All dogs had good to excellent long‐term outcomes, except one that experienced recurrence of a perineal hernia 2 years after repair.ConclusionIn vitro, canine FL allowed attachment and proliferation of fibroblasts throughout layers of the graft. Canine allogenic FL was clinically well tolerated in this small population of dogs.Clinical significanceAllogenic FL is biocompatible and can be considered an alternative to SIS for soft tissue augmentation in dogs.
Stress management in obesity during a thermal spa residential programme (ObesiStress): protocol for a randomised controlled trial study
Authors: Dutheil Frédéric , Chaplais Elodie , Vilmant Audrey , Courteix Daniel , Duche Pascale , Abergel Armand , Pfabigan Daniela M , Han Shihui , Mobdillon Laurie , Vallet Guillaume T , Mermillod Martial , Boudet Gil , Obert Philippe , Izem Omar , Miolanne-Debouit Magalie , Farigon Nicolas , Pereira Bruno , Boirie Yves 
Published: December 2019

IntroductionStress and obesity are two public health issues. The relationship between obesity and stress is biological through the actions of stress on the major hormones that regulate appetite (leptin and ghrelin). Many spa resorts in France specialise in the treatment of obesity, but no thermal spa currently proposes a specific programme to manage stress in obesity. The ObesiStress protocol has been designed to offer a new residential stress management programme. This thermal spa treatment of obesity implements stress management strategies as suggested by international recommendations.Methods and analysis140 overweight or obese participants with a Body Mass Index of >25 kg/m2and aged over 18 years will be recruited. Participants will be randomised into two groups: a control group of usual practice (restrictive diet, physical activity and thermal spa treatment) and an intervention group with stress management in addition to the usual practice. In the present protocol, parameters will be measured on five occasions (at inclusion, at the beginning of the spa (day 0), at the end of the spa (day 21), and at 6 and 12 months). The study will assess the participants’ heart rate variability, cardiac remodelling and function, electrodermal activity, blood markers, anthropometric profile, body composition, psychology and quality of life via the use of questionnaires and bone parameters.Ethics and disseminationThe ObesiStress protocol complies with the ethics guidelines for Clinical Research and has been approved by the ethics committee (CPP Sud-Est VI, Clermont-Ferrand - ANSM: 2016-A01774-47). This study aimed to highlight the efficacy of a 21-day thermal spa residential programme of stress management in obesity through objective measurements of well-being and cardiovascular morbidity. Results will be disseminated during several research conferences and articles published in peer-reviewed journals.Trial registration numberNCT03578757.
Efficacy of periacetabular osteotomy followed by progressive resistance training compared to progressive resistance training as non-surgical treatment in patients with hip dysplasia (PreserveHip) – a protocol for a randomised controlled trial
Authors: Reimer Lisa Cecilie Urup , Jakobsen Stig Storgaard , Mortensen Louise , Dalgas Ulrik , Jacobsen Julie Sandell , Soballe Kjeld , Bere Tone , Madsen Jan Erik , Nordsletten Lars , Risberg May Arna , Mechlenburg Inger 
Published: December 2019

IntroductionPeriacetabular osteotomy (PAO) is an established treatment for adolescent and adult patients with hip dysplasia. However, the efficacy of PAO has not been tested against another surgical intervention or conservative treatment in a randomised controlled trial before. We suggest that progressive resistance training (PRT) could be an alternative to PAO. The primary aim of this trial is therefore to examine the efficacy of PAO followed by 4 months of usual care followed by 8 months of PRT compared to 12 months of solely PRT in patients with hip dysplasia eligible for PAO in terms of patient-reported pain measured by The Copenhagen Hip and Groin Outcome Score (HAGOS).Methods and analysisThis trial is a single-blinded multicentre randomised controlled clinical trial, where patients with hip dysplasia, who are eligible for PAO, will be randomised to either PAO followed by usual care and PRT or PRT only. Primary outcome is patient-reported pain, measured on the subscale pain on the HAGOS questionnaire 12 months after initiation of PAO or PRT. The key secondary outcomes are the other subscales of the HAGOS, adverse and serious adverse events, usage of painkillers (yes/no) and type of analgesics. Based on the sample size calculation, the trial needs to include 96 patients.Ethics and disseminationThe trial is approved by the Central Denmark Region Committee on Biomedical Research Ethics (Journal No 1-10-72-234-18) and by the Danish Data Protection Agency (Journal No 1-16-02-120-19). The trial is also approved by The Regional Committee for Medical and Health Research Ethics, Region South-East Norway (Ref. 2018/1603). All results from this trial will be published in international peer-reviewed scientific journals regardless of whether the results are positive, negative or inconclusive.Trial registration numberNCT03941171
The Choice and Partnership Approach to community mental health and addictions services: a realist-informed scoping review protocol
Authors: Campbell Leslie Anne , Clark Sharon E , Ayn Caitlyn , Chorney Jill , Emberly Debbie , MacDonald Julie , MacKenzie Adrian , Marsh Daniel , Peacock Kylie , Wozney Lori 
Published: December 2019

IntroductionEarly identification and appropriate treatment of child and adolescent mental health disorders can often be hampered by patchwork services with poorly planned or unclear pathways. The Choice and Partnership Approach (CAPA) is an evidence-based transformational model of community (community-based or outpatient) mental health and addictions services for children and adolescents that aims to better match services to needs and to improve timely access to care. CAPA has been variably implemented across jurisdictions but has not been comprehensively evaluated for its impact on system and client outcomes. Our research question is, ‘To what degree does CAPA work, for whom and under what circumstances?’. The purpose of this review is twofold: (1) to gain an understanding of the extent and outcomes of the implementation of CAPA in community mental health and addictions services; and (2) to identify the role of context as it influences the implementation of CAPA and resulting client and system outcomes.Methods and analysisWe will conduct a realist-informed scoping review of the literature related to CAPA in either child and adolescent or adult community mental health and addictions services. Relevant studies, reports and documentation will be identified by searching the following online databases: MEDLINE, Embase, CINAHL, PsycINFO, Academic Search Premier, ERIC, Web of Science, Cochrane, Dissertations Abstracts, NCBI Bookshelf, PubMed Central and the Canadian Health Research Collection. The search strategy was developed by a health sciences library scientist and informed by a multidisciplinary team comprising methodological and content knowledge experts. The search will gather evidence from multiple online databases of peer-reviewed literature and grey literature repositories. All articles will be independently assessed for inclusion by pairs of reviewers. The key themes derived from a thematic analysis of extracted data will be presented in a narrative overview.Ethics and disseminationResearch ethics review is not required for this scoping review. The results will be disseminated through meetings with stakeholders (including clients and families, clinicians and decision-makers), conference presentations and peer-reviewed publication. The results of this review will inform an overarching programme of research, policy and quality indicator development to ultimately improve mental health and addictions care and subsequent mental health outcomes for children and adolescents.
Health-related quality of life in patients with diabetic foot ulceration: study protocol for adaptation and validation of patient-reported outcome measurements (PROMs) in Dutch-speaking patients
Authors: Rezaie Wahid , Lusendi Flora , Doggen Kris , Matricali Giovanni , Nobels Frank 
Published: December 2019

IntroductionDiabetic foot ulceration (DFU) is a common late-stage complication of diabetes with a large impact on health status and quality of life. Patient-reported outcome measures (PROMs) provide a standardised method of obtaining patients’ views on their well-being. The DFU Scale Short Form (DFS-SF) is a validated disease-specific PROM for measuring health-related quality of life among DFU patients. The Lower Extremity Functional Scale (LEFS) is another PROM that can be used to measure physical functioning in patients with lower extremity disorders. The LEFS is not yet validated for DFU. Both instruments are not validated in the Dutch language. The purpose of this study is to culturally adapt and validate the DFS-SF and LEFS questionnaires for Belgian Dutch-speaking patients with DFU.Methods and analysisThis study will be conducted as a monocentre observational cohort study in DFU patients presenting at a hospital-based multidisciplinary diabetic foot clinic. Data will be collected from the medical electronic files and from DFS-SF, LEFS and five-level EuroQol five-dimension questionnaires that will be presented to the patients at defined time points. Reproducibility, internal consistency, floor and ceiling effects, construct validity and responsiveness will be assessed for the DFS-SF and LEFS.Ethics and disseminationThe study protocol has been approved by the Medical Ethics Committee of Onze-Lieve-Vrouw Hospital (Aalst, Belgium). The results of the study will be disseminated through peer-reviewed publications and conference presentations.
Pulse wave velocity and short-term outcome in patients requiring intravascular volume expansion: a pilot study
Authors: Milan Alberto , Maldari Pietrantonio , Iannaccone Andrea , Leone Dario , Avenatti Eleonora , Molino Paola , Livigni Sergio , Veglio Franco , Aprà Franco 
Published: December 2019

BackgroundFluid therapy has a pivotal role in the management of acutely ill patients. However, whether or not a patient can tolerate additional intravascular volume is controversial and optimal strategy is unknown. Carotid femoral pulse wave velocity (cfPWV) evaluates arterial stiffness.ObjectiveTo determine whether cfPWV can predict the ability of patients to tolerate clinically indicated acute fluid expansion.Methods50 consecutive patients requiring intravascular volume expansion were prospectively recruited in intensive care units. All subjects underwent transthoracic echocardiography, pulmonary ultrasound assessment, and a cfPWV study (S. Giovanni Bosco Hospital in Turin, Italy, between 2015 and 2016) at baseline and after 24 hours. Acute outcomes were registered at 24 hours (“soft” end points) and 30 days ('hard' end points: death, acute myocardial infarction, stroke, occurrence of atrial fibrillation, need for dialysis) after initial fluid therapy. Multivariate logistic regression was used to assess association of the initial cfPWV with outcomes.ResultscfPWV was significantly higher (10.6±3.6 vs 7.4±2.2 m/s, P<0.0001) in subjects who met the prespecified combined endpoints (hard or soft) than in those who did not. After adjustment for confounding factors, initial cfPWV was significantly and independently associated with the occurrence of hard events (OR=2.8 (95% CI 1.36 to 5.97), P=0.005; area under the receiver operating characteristic curve 84%). cfPWV of <9 m/s had a negative predictive value of 93%, excluding hard events associated with fluid expansion.ConclusioncfPWV appears to reflect the ability of the patient to tolerate an intravascular fluid expansion when clinically indicated. Increased cfPWV could help to identify subjects at greater risk of developing signs and symptoms of fluid overload.
To bed or not to bed: the sleep question?
Authors: Brown Chris , Abdelrahman Tarig , Lewis Wyn , Pollitt John , Egan, Richard ,   the members of the Welsh Surgical Research Initiative, Abdulal Sabria , Ahmed Jake , Ahmad Adnan , Allen Nicola , Ansell James , Arnaudov Stefan , Barnett Rachael , Beamish Andrew , Bosanquet David , Chan David , Chandler Susan , Dewi Madlen , Dwalesena Sam , Gardner Andrew , Gonzi Gianluca , Harries Rhiannon , Hopkins Luke , Hopkins Michael , James Osian , Jawad Ali , Jones Dylan , Jones Huw , Jones Rod , Luton Oliver , Marusza Christopher , Measuria Harshul , Mehta Samir , Pearce Jack , Petralia Tito , Powell Arfon , Powell-Chandler Anna , Reeves Nicola , Selwyn David , Seymour Zoe , Ved Ronak 
Published: December 2019

AbstractBackgroundSleep deprivation and fatigue from long-shift work impacts doctors’ personal safety, inhibits cognitive performance and risks clinical error. The aim of this study was to assess the sleep quality of surgical trainees participating in European Working Time Directive-compliant training rotations within a UK deanery.MethodsA trainee cohort numbering 38 (21 core, 17 higher surgical trainees, 29 men and 9 women, median age 31 (25–44 years)) completed a sleep diary over 30 days using the Sleep Time (Azumio) smartphone application and triangulated with on-call rosters to identify shift patterns. The primary outcome measure was sleep quality related to rostered clinical duties.ResultsConsecutive 1152 individual sleep episodes were recorded. The median time asleep (hours:min) was 6:29 (5:27–7:19); the median sleep efficiency was 86% (80%–93%); the median light sleep (hours:min) was 2:50 (1:50–3:49); and the median rapid eye movement (REM) sleep (hours:min) was 3:20 (2:37–4:07). Significant adverse sleep profiles were observed in trainees undertaking emergency on-call duty when compared with elective (non-on-call) duty; the median time asleep (hours:min) 5:49 vs 6:43 (p&lt;0.001); the median sleep efficiency was 85% vs 87% (p&lt;0.001); the median light sleep (hours:min) was 2:16 vs 2:58 (p&lt;0.001); and REM sleep (hours:min) was 2:57 vs 3:27 (p&lt;0.001). Recovery of sleep duration, efficiency and quality necessitated five full days of time.ConclusionSurgical emergency on-call duty adversely influences sleep quality. Proper consideration of fail-safe rota design, prioritising sleep hygiene, recovery and well-being, allied to robust patient safety and quality of care should be made a priority.
Changing perceptions: a multicentre survey of final-year medical students’ and junior doctors’ perceptions of diabetes and endocrinology
Authors: Puttanna Amar , Byrne Megan L , Eyre-Brook Susannah N , Madhra Mayuri , Nwokolo Munachiso , Mitchell Anna 
Published: December 2019

AbstractPurpose of the studyThe National Health Service is experiencing a recruitment crisis across many medical specialties. Diabetes and endocrinology (D&E) is failing to fill training posts with only 77%, 83% and 73% of posts filled overall in 2016, 2017 and 2018, respectively.Study designWe surveyed 316 final-year medical students and undifferentiated trainees (from foundation programme doctors to core medical trainees), across the South Thames, Northern and West Midlands deaneries in England to gain an understanding of perceptions of the specialty.Results9% of respondents were considering a career in D&E. Factors such as ‘being the medical registrar’ (27%), being a ‘non-procedural specialty’ (23%) and ‘looking after majority of general medical admissions’ (22%) were cited as the most common reasons why D&E is an unattractive career choice. 51% reported inadequate exposure to D&E. Factors that made respondents more likely to want to pursue a career in D&E included having undertaken a placement in the specialty and having exposure to outpatient clinics. Methods to improve awareness and uptake, such as increased teaching and clinical exposure, and the opportunity to attend taster events were frequently highlighted.ConclusionsThe results from this survey, the first of its kind on perceptions of D&E as a career pathway, reveal a worrying lack of interest in, and exposure to, D&E among current final-year medical students and undifferentiated trainees. These issues must be addressed in order to improve D&E recruitment rates.
Inspiring the next generation of surgeons
Authors: Khan Shujhat 
Published: December 2019

AbstractThe shortage of applicants looking to enter surgical specialties is well documented. Indeed, there are a number of reasons for this ranging from potential flaws within the training pathway to a lack of both financial and social support in what is undoubtedly a stressful career pathway. However, it is important that we discuss these shortcomings and exploit such opportunities to make surgery a more attractive prospect. These changes include adapting student’s experience while still at medical school through changes to the medical curriculum and surgical rotations. In addition, it is important to assess what factors applicants prioritise when applying for specialty training, and addressing the gender divide within surgery so as to remove barriers for progression in surgical training. Similarly, by encouraging research within surgery, it improves treatment options for patients as well as motivating those more academically inclined to pursue this specialty. This can produce more proficient surgeons and improve the competitiveness of training posts within remote regions in the UK. Ultimately, these changes will likely translate to more satisfied trainees and improved patient care.
Single-spin asymmetries in $$p^\uparrow p \rightarrow J/\psi +X$$ within a TMD approach: role of the color octet mechanism
Authors: D’Alesio Umberto , Murgia Francesco , Pisano Cristian , Rajesh Sangem 
Published: December 2019

AbstractWe calculate the transverse single-spin asymmetry (SSA) for $$J/\psi $$J/ψ production in proton-proton collisions, within non-relativistic QCD, employing the transverse momentum dependent, generalized parton model, which includes both spin and intrinsic motion effects. In particular, we study the role of the color octet mechanism in accessing the gluon Sivers function. In doing that, we also show, within this approach, how the singularities coming from color octet terms in the low-$$P_T$$PT region can be handled, leading to finite cross sections. Predictions for both unpolarized cross sections and SSAs are given and compared against PHENIX data. Estimates for LHCb in the fixed target mode are also presented.
Musicoterapia no processo de reabilitação de pacientes com amputação
Authors: Smith Maristela Pires da Cruz , Alves Vera Lucia Rodrigues 
Published: December 2019

A visão de totalidade do homem - homem como ser social - sugere que as ações reabilitadoras, aplicadas a pacientes acometidos por síndromes que os incapacitam fisicamente - como amputações de membros do corpo - mostram-se eficazes resultando numa melhora, e mais rápida readaptação do sujeito, a novas formas de ‘estar no mundo’, mesmo vivenciando um estigma social de “pessoa diferente”. No estudo em questão trabalhou-se com os pressupostos epistemológicos da Psicologia Social Crítica, que foram demonstrados por meio de técnicas da Musicoterapia, pois se esperava que a prática de sessões de musicoterapia poderia facilitar a expressão da música interna dos sujeitos, conteúdo este narrado por meio de palavras, que foram transformadas em palavras cantadas e, posteriormente, em canções compostas. A participação dos envolvidos no trabalho clínico foi conjunta, isto é, entre pesquisadores e cada um dos 5 pacientes participantes, atendidos individualmente, já que se tratou de uma pesquisa-ação-participativa. As análises de discurso das narrativas de histórias de vida, foram feitas com base nas categorias que fundamentam a Psicologia Social Crítica. Os registros foram feitos a partir de observações do comportamento sonoro-musical dos pacientes, aplicando-se o “Modelo de Registro de Reações Sonoro-Rítmico-Musicais, Corpóreo-Vocais e Comportamentais”, tanto para o registro objetivo, quanto para as interpretações musicais subjetivas, tendo como referência teórica principal a ‘identidade como metamorfose’.