bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual Approach for Treatment of Primary Intestinal Lymphangiectasia in Children: Single-center Experience and Systemic Review
Authors: Kwon Yiyoung , Kim Mi Jin , Kim Eun Sil , Choe Yon Ho 
Published: September 2020

Abstract
Background: Intestinal lymphangiectasia is a rare disease. Thus, prospective studies are impossible, and therapy is still controversial. Several medicines are suggested for treatment but there are no existing indications for drug choice and treatment guidelines. We experienced seven patients with primary intestinal lymphangiectasia who showed clinical improvement with different treatments. Aim: We aimed to introduce the action mechanism of each drug and treatment overview in a single-center experience and a systemic review of second-line therapy for primary intestinal lymphangiectasia.Method: Children under 18 years old diagnosed with intestinal lymphangiectasia from June 2000 to June 2020 were included in the study. Capsule endoscopy, MR lymphangiography, or whole-body MRI for investigating the extent of abnormal lymphatic vessels in addition to endoscopy and biopsy were conducted. The individual treatment approaches depended upon the lymphangiectasis locations involved.Results: Only one patient showed a response to dietary therapy. One patient was successfully cured after two therapeutic lymphatic embolization. Octreotide was tried for two patients who had extensive lymphangiectasis. Lymphangiectasis recurred when octreotide was used for three months in one patient, and there was no effect in the other patient. Sirolimus was tried for four patients. Two of them had abnormal lymphatic lesions only in the intestine, and the others had extensive lymphangiectasis. The former group showed clinical improvement after 3 – 4 months of sirolimus treatment, whereas the latter group showed clinical improvement only after one month of sirolimus treatment.Conclusion: Intervention is a potential therapeutic option for patients with focal abnormal lymphatic lesions. Octreotide is not an optimal choice for patients with extensive lymphangiectasis. Sirolimus is an effective and safe drug and can be the first drug of choice for patients with extensive lymphangiectasis.
Comparison Between Cemented and Uncemented Hemiarthroplasty in Patients With Femoral Neck Fractures: A Systematic Review and Meta-analysis
Authors: Tang Xiu Mei , Wang Duan , Liu Ying , Chen Jia Li , Li Pei Fang , Zhou Zong Ke , Ning Ning 
Published: September 2020

Abstract
BackgroundWe performed an updated systematic review and meta-analysis to compare the outcomes of CHA and UCHA in patients with FNFs.MethodsWe searched 6 English databases (Cochrane Library, ScienceDirect, PubMed, Embase, Medline, and Web of Science) and 4 Chinese databases (CNKI, VIP, Wang Fang, and Sino Med) in July 2020. The quality of each study was assessed according to the Cochrane handbook of systematic reviews. Data were pooled as risk ratios (RRs) and weighted mean differences (WMDs) with 95% confidence intervals (95% CIs). We used the random-effects model despite the heterogeneity among the studies. Data regarding baseline characteristics, hip function, complications both prosthetic-related and common, and operative outcomes are reported. ResultsA total of 24 RCTs based on 22 trials involving 3119 patients (CHA, 1575; UCHA, 1544) were included. Patients in CHA group show better hip function with HHS within 6 weeks (WMD=9.097, 95% CI, 3.034-15.161; P<0.003), 3 months (WMD=3.347, 95% CI, 1.478-5.216; P<0.001), 12 months (WMD=2.183, 95% CI, 0.161-4.205; P=0.034). The pooled results show that CHA had lower rates of refracture (RR=0.227, 95% CI, 0.135-0.381; P<0.0001), subsidence or loosening (RR=0.295, 95% CI, 0.112,0.778; P<0.014) and revision (RR=0.468, 95% CI, 0.279-0.786; P=0.004). Furthermore, CHA group tend to have lower pain(VAS score) (WMD=-0.568, 95% CI, -0.897 to -0.239; P=0.001), lower rate of pressure injury(RR=0.432, 95% CI, 0.221-0.846; P=0.014) and mortality at 1 year after surgery(RR=0.852, 95% CI, 0.727-0.998; P=0.047). UCHA showed a shorter operative duration(WMD=8.739, 95% CI, 6.354-11.124; P<0.0001).ConclusionsThis meta-analysis demonstrates that CHA has better hip function, lower rates of refracture, subsidence or loosening, revision, pressure ulcer, pain and one-year mortality than UCHA, while UCHA has shorter operative duration.
Population Transcriptomes Reveal the Interspecific Adaptive Genetic Differentiation of Liriodendron by Landscape Genetics
Authors: Shen Yufang , Xia Hui , Tu Zhonghua , Zong Yaxian , Yang Lichun , Li Huogen 
Published: September 2020

Abstract
Background: Adaptive genetic differentiation is a hotspot in the research of speciation mechanisms in evolutionary biology. Genomic resources are important for detecting ecological adaptive evolution of non-model plants. Using RNA-seq for non-model plants is a good approach to obtain their genomic resources. The combination of population transcriptome resources and environmental data can provide insights into the genetic mechanism of adaptive genetic differentiation.Results: Based on the population transcriptome data, we investigated the spatial distribution of genetic variations in Liriodendron to detect relationships between ecological factors and genetic differentiation. Environmental data and genetic variations from 17 populations were integrated to detect the population structure, adaptive genes and key environmental factors that shape the population genetic structure by landscape genetic approach. Here, we identified 16592 high-quality single nucleotide polymorphisms (SNPs). The population structure analysis results showed that 17 populations were divided into three groups: L. tulipifera, eastern group and western group of L. chinense. Redundancy analysis and latent factor mixed model analysis suggested that precipitation seasonality, precipitation in the driest quarter, diurnal temperature, and solar radiation in May were closely associated with the adaptive genetic differentiation of Liriodendron. Ecological niche differentiation analysis implied significant ecological niche divergence between L. chinense and L. tulipifera habitats. In total, 858 environment-related loci were identified, which were associated with 464 genes. Pathway enrichment analysis revealed that these genes were significantly enriched in multiple biological pathways. Related studies confirmed that these biological pathways play vital roles in plant growth, development, stress, immune response and photosynthesis.Conclusions: Our research provided empirical evidence that environmental factors may play a key role in driving adaptive genetic differentiation of species. Furthermore, the combination of population transcriptome resources and environmental datasets provides new insights into the study of adaptive genetic differentiation of species.
Development of a Simple Method to Measure Static Body Weight Distribution in Neurologically Normal Small Breed Dogs
Authors: Linder Jessica E , Thomovsky Stephanie , Bowditch Jessica , Lind Mallory , Kazmierczak Kristine A , Breur Gert J , Lewis Melissa J 
Published: September 2020

Abstract
Background: Objective outcome measures capable of tracking different aspects of functional recovery in dogs with acute intervertebral disc herniation are needed to optimize physical rehabilitation protocols. Normal, pre-injury distribution of body weight in this population is unknown. The aims of this study were to quantify static weight distribution (SWD) using digital scales and to establish the feasibility of different scale methods in neurologically normal, chondrodystrophic small breed dogs predisposed to intervertebral disc herniation. Results: Twenty-five healthy dogs were enrolled with a mean age of 4.6 years (SD 2.7) and a mean total body weight of 11.5 kg (SD 3.6). SWD for the thoracic and pelvic limbs and between individual limbs was acquired in triplicate and expressed as a percentage of total body weight using commercially available digital scales in four combinations: two bathroom, two kitchen (with thoracic and pelvic limbs combined), four bathroom and four kitchen (with limbs measured individually). SWD was also obtained using a pressure sensing walkway for comparison to scale data. Feasibility for each method was determined and coefficients of variation were used to calculate inter-trial variability. Mean SWD values were compared between methods using an ANOVA. The two bathroom scales method had the highest feasibility and lowest inter-trial variability and resulted in mean thoracic and pelvic limb SWD of 63% (SD 3%) and 37% (SD 3%), respectively. Thoracic limb mean SWD was higher for the PSW compared to any of the scale methods (p<0.0001). Conclusions: SWD in a population of healthy chondrodystrophic dogs was simple to obtain using inexpensive and readily available digital scales. This study generated SWD data for subsequent comparison to dogs recovering from acute intervertebral disc herniation.
The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China
Authors: Huang Xiaoli , Chen Jichang , Zeng Dingyuan , Lin Zhong , Herbert Carly , Cottrell Lesley , Liu Liu , Ash Arlene , Wang Bo 
Published: September 2020

Abstract
Background: Studies suggest that exposure to ambient air pollution during pregnancy may be associated with increased risks of birth defects (BDs), but conclusions have been inconsistent. This study describes the ethnic distribution of major BDs and examines the relationship between air pollution and BDs among different ethnic groups in Liuzhou city, China.Methods: Surveillance data of infants born in 114 registered hospitals in Liuzhou in 2019 were analyzed to determine the epidemiology of BDs across five major ethnic groups. Concentrations of six air pollutants (PM2.5, PM10, SO2, CO, NO2, O3) were obtained from the Liuzhou Environmental Protection Bureau. Logistic regression was used to examine the associations between ambient air exposure and risk of BDs.Results: Among 32,549 infants, 635 infants had BDs, yielding a prevalence of 19.5 per 1000 perinatal infants. Dong ethnic group had the highest prevalence of BDs (2.59%), followed by Yao (2.57%), Miao (2.35%), Zhuang (2.07%), Han (1.75%). Relative to the Han ethnic group, Zhuang, Miao, Yao and Dong groups had lower risks of congenital heart disease, polydactyly, and hypospadias. The Zhuang ethnic group had higher risks of severe thalassemia, cleft lip and/or palate, and syndactyls. Our analysis of the correlation between air pollution and BDs showed that BDs were positively correlated with air pollutants PM10 (aORs =1.14; 95% CI:1.12-2.43 for per 10ug/mg3 increment) and CO (aORs =1.36; 95% CI:1.14-2.48 for every 1mg /m3 increment) in second month of pregnancy, and were associated with PM10 (aORs =1.51; 95% CI:1.13-2.03) and CO (aORs =1.75; 95%CI:1.02-3.61) in the third month of pregnancy. SO2 also had a significant association with BDs in the second month of the pregnancy (aORs =1.31; 95% CI:1.20-3.22) and third month of pregnancy (aORs =1.75; 95% CI:1.02-3.61). However, no signiﬁcant association was found between birth defects and O3, PM2.5 and NO2 (P > 0.05). Conclusion: This study provided a comprehensive description of ethnic differences in BDs in Southwest China, and broadens the evidence of association between air pollution exposure during gestation and BDs.
The effectiveness of a mobile phone education-based on self-efficacy and DASH diet among patient with high blood pressure: a randomized controlled trial
Authors: Darabi Zahra , Araban Marzieh , Azizi Amir Abbas , Angali Kambiz Ahmadi , Borazjani Fatemeh 
Published: September 2020

Abstract
Background: Hypertension HTN is a global public health problem with an increasing incidence worldwide. On one hand the imperative role of self-efficacy in controlling of chronic disease has been reported; on the other hand, dietary approach to stop hypertension (DASH) diet reported as one of most appropriate dietary approaches for controlling HTN. Here in present study we aimed to investigate the efficiency of mobile app for improving self-efficacy on adherence of DASH diet in HTN patients. Methods: the present randomized controlled trial conducted on 88 patients with hypertension who referring to public health care centers between Novomber2019 to March 2020. The subjects were randomly assigned to receive mobile app for DASH-related recommendation +usual care; or control group to follow their habitual diets and given usual health care in public health care centers for twelve weeks. Self-efficacy, SBP and DBP, body mass index, physical activity and dietary intakes were assessed at the baseline and the end of trial. The ANCOVA was used to show the differences between the two groups and adjusting for baseline and covariates. Results: Results showed that whilst there were no significant differences in DBP and SBP at the baseline, but intervention lead to significant decrease in both SBP and DBP. Results from self-efficacy showed that baseline values were not significantly different between two groups; however, all five components improved significantly at the end of trial. Conclusion: Here we showed that using mobile apps for educating DASH diet and improving self-efficacy lead to better control of BP among patients whilst their self-efficacy improved simultaneously.Trial registration: Iran Clinical Trials Registry: IRCT20190930044933N1.Date of registration:31.10.2019URL of trial registry record: https://www.irct.ir/trial/42612
Spatial Distribution and Associated Factors of Institutional Delivery Among Reproductive-Age Women (15-49 Years) in Ethiopia: The Case of Ethiopian Demographic and Health Survey 2016 Data
Authors: Sisay Daniel , Muche Temesgen , Ali Helen 
Published: September 2020

Abstract
Background: Globally, there were an estimated 289,000 maternal deaths in 2013, yielding Maternal Mortality Rate (MMR) of 210 maternal deaths per 100,000 live births. Still, now maternal mortality in Ethiopia is the highest in the world.Methods: This study is a secondary data analysis of the 2016 EDHS. A total of 7590 women who gave birth in the last 5 years preceding the survey were included in the analysis was carried out by using Geographic information system and clusters with high and low hotspots with institutional delivery were identified using Sat Scan spatial statistical analysis. A multilevel multivariable mixed-effect logistic regression was used to identify factors associated with institutional delivery.Result: In this study, 33.25% of women who gave birth in the last 5 years preceding the survey were delivered at the health institution. The finding also indicated that the spatial distribution of institutional delivery was non-random in the country. At the individual level, the riches (AOR=2.18,95%CI:1.39-3.41), higher education(AOR=3.89,95%CI:1.51-10.01), four and above the number of antenatal care visits (AOR=6.57,95%CI:4.83-8.94) and parity more than two children(AOR=0.48,95%CI:0.34-0.68), and at the community level, higher education (AOR=1.70,95%CI:1.22-2.36), urban residence (AOR=5.30, 95%CI:3.10-9.06), were variables that had achieved statically significant association for utilization of institutional deliveryConclusions: This study identified a spatial cluster of institutional delivery of Somali and Afar region have low utilization rates and Addis Ababa and Tigray regions have the highest utilization rate. The significant associated factors of institution delivery were Individual factor of woman antenatal care visit, Household wealth index, Maternal education, Parity, and Community factor of Region, Place of residence, and Educational status, Therefore, to maximize health facility delivery in Ethiopia, the predictors of institutional delivery identified in this study should be given more attention by governmental and non-governmental stakeholders
Leaf Transcriptome Analysis of Medicago Ruthenica, Revealing Its Response and Adaptive Strategy to Drought Stress and Rehydration
Authors: Wu Rina , Xu Bo , Shi Fengling 
Published: September 2020

Abstract
Background: Recently, drought stress has brought tremendous loss on the production of agriculture and animal husbandry. In realistic production, plants are often in cyclic wet-dry environment. Therefore, the factors that affect the final yield of plants in adversity including the resistance and tolerance to drought and the ability of plants to resume from the previous damage after rehydration. So it’s necessary for us to study the response and adaptive strategies of plants to drought and rehydration. Generally, the yield of herbage with strong resistance is relatively low. However, Medicago ruthenica(L.)cv.Zhilixing has the advantages of strong resistance and high yield concurrently. This made it can be used for raising livestock, natural grassland improvement, as a good parent for breeding and a new and high quality resource of stress resistance genes. Now, there are still many problems need to be solved when compared with other important legume forages. Therefore, we analyzed the changes of Medicago ruthenica(L.)cv.Zhilixing on transcription level under drought stress and rehydration, explored its phased response strategies.Results: We obtained 191 DEGs in drought stress, and the three treatments has 43 DEGs in common. Galactose metabolism, Starch and sucrose metabolism, Arginine and proline metabolism, TCA cycle, Photosynthesis-antenna proteins, were involved in the adaptation of Medicago ruthenica to 9 days of drought stress. The regulation of Arginine and proline metabolism, Cysteine and methionine metabolism, Photosynthesis-antenna proteins, Ascorbate and aldarate metabolism were conducive to the resistance of Medicago ruthenica to severe drought stress. The regulation of Starch and sucrose metabolism, Flavonoid biosynthesis, Valine, leucine and isoleucine degradation, Circadian rhythm-plant was beneficial to the post drought recovery of Medicago ruthenica.Conclusions: We preliminarily analyzed the adaptation mechanism of the plant under different drought and rehydration conditions. Medicago ruthenica(L.)cv.Zhilixing adopts different strategies to adapt to different degrees of drought stress and rehydration. The research discovered the genes that can be used as candidate genes to improve stress resistance and drought adaptability of plants. Our transcriptome data dramatically enriches the resources of stress resistance genes. It can provide theoretical support for further adaptation mechanism research of the plant under different drought and rehydration conditions.
Association between single nucleotide polymorphisms in CDKAL1 and HHEX and type 2 diabetes in Chinese Population
Authors: Li Chuanyin , Shen Keyu , Yang Man , Yang Ying , Tao Wenyu , He Siqi , Shi Li , Yao Yufeng , Li Yiping 
Published: September 2020

Abstract
Background: Type 2 diabetes mellitus (T2DM) has a high global prevalence, and the interaction of environmental factors and genetic factors may contribute to the risk of T2DM. We aimed to investigate the association between T2DM and the single nucleotide polymorphisms (SNPs) in genes associated with insulin secretion is necessary. Methods: T2DM (1169) and nondiabetic (NDM) (1277) subjects were enrolled and the eight SNPs in CDKAL1 and HHEX associated with insulin secretion were genotyped in a Chinese population.Results: Our result revealed that four SNPs (rs4712524, rs10946398, rs7754840 in CDKAL1 and rs5015480 in HHEX) showed significantly different genotype frequencies in the T2DM and NDM groups (P<0.00625). The G allele of rs4712524(P=0.004, OR=1.184; 95%CI: 1.057-1.327) , C allele of rs10946398(P<0.001, OR=1.247; 95%CI: 1.112-1.398) and C allele of rs775480 in CDKAL1 (P<0.001, OR=1.229; 95%CI: 1.096-1.387) functioned as risk allele in incidence of T2DM. The C allele of rs5015480 in HHEX (P<0.001, OR=1.295; 95%CI: 1.124-1.493) was risk factor for the development of T2DM. The haplotype analysis revealed that rs4712524-rs10946398-rs7754840-rs9460546GCCG (P=0.001, OR=1.210; 95%CI: 1.076-1.360) was associated with a greater risk of T2DM development. Moreover, The HHEX rs1111875-rs5015480 haplotype analysis with D’>0.9 showed that rs1111875-rs5015480CC was associated with development of T2DM(P=2.63×10-5, OR=1.364; 95%CI:1.180-1.576). In the inheritance models analysis, the best fit inheritance model for rs4712524, rs10946398, and rs7754840 in CDKAL1 and rs5015480 in HHEX were all log-additive. Conclusion: Our results revealed that genetic variations in CDKAL1 and HHEX were associated with T2DM susceptibility in a Chinese population.
Violence Against Women and Perceived Health: An Observational Survey of Consultants in Family Planning Centers in the Paris, France, Region.
Authors: Ahogbehossou Yélian , Roland Noémie , Hatem Ghada , Yacini Leila , Feldmann Laure , Saurel-Cubizolles Marie-Josèphe , Bardou Marc 
Published: September 2020

Abstract
Background. Suffering violence has both short- and long-term negative effects on women’s health. We set out to study the relationship between socio-demographic characteristics of women attending three Family Planning Centers (FPCs) in France and the violence they experienced and to the association between women’s perception of their health status and their exposure to violence. Methods. We conducted an observational survey of clinical practice from December 2018 to February 2019 at three FPCs in Seine-Saint-Denis (Ile-de-France). All women patients aged 18 years or older were eligible. We solicited data on social characteristics, precariousness, and suffering violence. We measured health status on a 10-point scales for six different symptoms.Results. Of the 274 women who participated, 28% had experienced violence. This percentage was higher among women living in socially precarious situations compared to the not or slightly precarious (39.3% vs 15.8%, respectively). Experiencing violence was significantly associated with being between 25 and 44 years old, being in a temporary or irregular administrative situation, being unemployed or seeking a job, and being in a precarious to very precarious situation. The proportion of women reporting domestic violence was more than twice as high in those consulting in FPC-1 (42%) than in FPC-2 (20%) or FPC-3 (16.2%). Regardless of age, history of violence was significantly associated with poor sleep, poor diet, low morale, and poor health in general for all FPCs and all levels of precariousness. Conclusion. Our study reveals that reports of violence against women increased with migratory status and precariousness, unemployment or job-seeking, and a poorer state perception of one’s own health in a population drawn from three Family Planning Centers in Seine-Saint-Denis. It also suggests a structure specifically dedicated to the management of women victim of violence that FPC-1, may be perceived more attractive by women exposed to domestic violence. The study was retrospectively registered: ClinicalTrials.gov Identifier: NCT04304469