bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes After Transcatheter Aortic Valve Replacement in Cancer Survivors with Prior Chest Radiation Therapy: A Systematic Review and Meta-Analysis
Authors: Zafar Meer Rabeel , Mustafa Syed Farrukh , Miller Timothy W , Alkhawlani Talal , Sharma Umesh C 
Published: June 2020

Abstract
Background : Cancer survivors with prior chest radiation therapy (C-XRT) frequently present with aortic stenosis (AS) as the first manifestation of radiation-induced heart disease. They are considered high-risk for surgical valve replacement. Transcatheter aortic valve replacement (TAVR) is as an attractive option for this patient population but the outcomes are not well established in major clinical trials. The authors performed a systemic review and meta-analysis of clinical studies for the outcomes after TAVR in cancer survivors with prior C-XRT. Methods: Online databases were searched from inception to April 2020 for studies evaluating the outcomes of TAVR in patients with and without C-XRT. We analyzed the pooled estimates (with their 95% confidence intervals) of the odds ratio (OR) for the all-cause mortality at 30-day and 1-year follow-ups, 4-point safety outcomes (stroke, major bleed, access-related vascular complications and need for a pacemaker), a 2-point efficacy outcome (mean aortic valve gradient and left ventricular ejection fraction) and worsening of congestive heart failure (CHF). Four studies were included following 2054 patients with and without prior C-XRT exposure (164 patients and 1890 patients respectively). Results: The C-XRT group had similar 30-day mortality compared to the control group (OR 1.29, 95% CI 0.64 to 2.58, p=0.48). The 1-year mortality was higher in the C-XRT group (OR 1.97, CI 1.15 to 3.39, p=0.01). Apart from higher congestive heart failure (CHF) exacerbation in the C-XRT group (OR 2.03, CI 1.36 to 3.04, p=0.0006), TAVR resulted in similar safety and efficacy outcomes in both groups. Conclusion: TAVR in the C-XRT group has similar 30-day mortality, safety, and efficacy outcomes compared to the control group; however, they have higher 1-year mortality and CHF exacerbation. Including an oncologist to the cardiology team who considers cancer stage in the decision-making process and applying additional preoperative scores such as frailty indices may refine the risk assessment for these patients. The quality of analyzed data is modest, warranting randomized trials to assess the true benefits of TAVR in these patients.
A new educational method before total knee arthroplasty to be applied in developing countries: a randomized controlled trial
Authors: Andrade Marco Antonio Percope de , Silva Guilherme Moreira Abreu e , Campos Tulio Vinicius Oliveira , Barbosa David Guen Kasuya , Leite Danilo Silva , Rezende Marcus Vinicius Teodoro , Magalhães Tauam Filipe Galo , Santos Felipe Maciel 
Published: June 2020

Abstract
Background

In developing countries, the illiteracy index is high in public hospitals. We describe a method in which patients are instructed before total knee arthroplasty (TKA) in a differentiated way without the necessity of reading any self-orientation.
Methods

To improve patient education before TKA we developed a multidisciplinary method in which an orthopedic surgeon, a nurse and a physiotherapist give the patients a differentiated orientation with specific lectures regarding the pre, intra and post-operative issues in a prospective case-control study of 79 consecutive patients undergoing primary TKA. Twenty-nine patients received the standard verbal education (control group) and 38 patients received the differentiated education (intervention group). The patients were evaluated during at least six months.
Results

After a 6-month follow-up period, SF-36 and WOMAC forms, VAS and range of motion improved significantly in both groups. ROM was better in the intervention group (mean and SD − 106.9 ± 5.7 versus 92.5 ± 12.1 degrees, p = 0.02). Moreover, walk ability (more than 400 meters) was improved in the intervention group compared with control group (97.4% versus 72.4%, p = 0.003). In the intervention and control groups, respectively, 10.5% and 31% of patients reported the need of some walking device (p = 0.03).
Conclusions

A differentiated educational program with a multidisciplinary team had a positive impact on functional outcomes, improving ROM and walk ability of patients undergoing TKA in a short-term evaluation.
Treatment Of Ruptured Tiny Intracranial Aneurysms By Electrocoagulation With Guidewire Manipulation:12 Cases Report
Authors: Xia Lixia , Hao Zhongfei , Wang Hongjun , Feng Yan , Zhan Yongxuan , Chen Minghui , Xie Peng , Li Qingbin , Li Ruiyan , Liu Yang , Wang Feng , Fang Yuequn , Li Youxiang , Li Yongli 
Published: June 2020

Abstract
Background: Ruptured tiny intracranial aneurysm (RTIA) is particularly rare seen. Treatment of RTIA is more difficult and not under control.Methods: We hereby present twelve rare cases of RTIA that were diagnosed based on DSA. These patients were found due to spontaneous or traumatic SAH, 11 of whom were treated only by electrocoagulation, and one of whom was treated by stent-assisted coiling and electrocoagulation.Results: There were eight patients with aneurysms located in posterior circulation and four patients with aneurysms located in anterior circulation. 11 patients were cured only by electrocoagulation merely: ten patient’ RTIA disappeared completely and immediately and another patient’s RTIA was thrombosed two months later. The twelfth patient was carried out stent-assisted coiling and electrocoagulation. The twelve patients’ average follow-up time was 12.5 months and the outcomes were all surprisingly excellent. No revascularization of aneurysm was found. Conclusions: Electrocoagulation with guidewire manipulation is a suitable method to treat RTIA. While large-scale studies with long-term follow-up are required to validate these promising results.
Perceptions in a Cohort of Women Exposed to Intimate Partner Violence (IPV)
Authors: Leuenberger Laura , McCall-Hosenfeld Jennifer , Lehman Erik 
Published: June 2020

Abstract
BackgroundAlmost one-half of American women will experience intimate partner violence (IPV), defined as physical, sexual, or psychological harm by a current or former partner. IPV is associated with an increased risk of homicide, with firearms as the most commonly used weapon. We designed this study to better understand the impact of interpersonal trauma exposure and demographic factors on firearm perceptions among a cohort of IPV-exposed women. Methods267 women in central Pennsylvania with exposure to IPV were surveyed about perceptions of gun access, safety, and gun presence in the home. Trauma variables included IPV type, IPV recency, unwanted sexual exposure, and adverse childhood experiences (ACEs). Multivariable analyses examined each of the three firearm perception questions controlling for trauma exposures and demographics. ResultsEase of firearm acquisition: Women who reported physical IPV (aOR2.40, 95%CI 1.20,4.81), women who reported past year unwanted sexual exposure (aOR4.01, 95% CI 1.00,16.03), and women of ages 47-54 (aOR3.57 95%CI 1.49,8.55) reported that guns were easy to acquire, compared to women ages 19-34. Perceived safety in the proximity of a gun: Women with the highest ACE score were less likely to feel safe with a gun nearby (aOR0.41, 95%CI 0.21,0.84). Rural women (aOR4.13, 95%CI 1.55,11.01), and women ages 35-46 had increased odds (aOR2.88, 95%CI 1.35,6.12) of reporting that guns made them feel safer. Odds of guns in the home: Women who were divorced or separated (aOR0.22, 95%CI 0.09,0.54) and women were widowed or single (aOR0.22, 95%CI 0.07,0.68) had lower odds of having a gun in the home, compared to married women. Rural women had higher odds of living in a home with a gun (aOR3.30, 95%CI 1.04,10.49). There was no significant effect of the trauma variables on the odds of having a gun at home. ConclusionsTrauma exposures, including physical IPV and past-year unwanted sexual exposure, were associated with women’s perceptions that it was easier to acquire guns in their community. Women with more severe childhood trauma felt less safe around firearms, but trauma exposures did not predict gun ownership. Instead, demographics of being married and rural residence were associated with gun ownership.
Prevalence of Enterobius Vermicularis Infections and Associated Risk Factors Among Schoolchildren in Nakhon Si Thammarat, Thailand
Authors: Laoraksawong Pokkamol , Pansuwan Pimyada , Krongchon Supakrit , Pongpanitanont Pongphan , Janwan Penchom 
Published: June 2020

Abstract
Objective: Enterobius vermicularis infection is an important public health problem worldwide, especially among schoolchildren in tropical and subtropical countries. The prevalence of E. vermicularis infections varies in each region of Thailand, but its status remains unknown among children who live in rural areas of southern region. This study aimed to evaluate the current prevalence of E. vermicularis infections and to identify the risk factors for infection among schoolchildren who live in rural communities in Nakhon Si Thammarat, Southern Thailand.Results: The overall prevalence of E. vermicularis infections was 5.79% (23 of 397). According to the multivariate analysis, the following were found to be risk factors associated with E. vermicularis infections (P < 0.05): male sex (AOR = 4.03, 95%CI 1.22-13.29), age group 3-6 years (AOR = 4.85, 95%CI 1.51-15.59), those having mother’s education level of primary school (AOR = 11.22, 95%CI 1.75-71.77), those having older sibling(s) (AOR = 6.25, 95%CI 1.83-21.26), those having younger sibling(s) (AOR = 6.24, 95%CI 2.00-19.44), those sometimes washing hands after using toilet (AOR = 5.25, 95%CI 1.24-22.21), those keeping fingernail long (AOR = 29.97, 95%CI 6.16-145.85), and those sucking their finger (AOR = 3.59, 95%CI 1.21-10.66).
Comparing the Effect of Face-to-Face with Phone Counselling Based on Cognitive-Behavioral Therapy on Vasomotor Symptoms in Postmenopausal Women: A Randomized Controlled Trial
Authors: Joola Nasim Sadeghi , Afshari Pourandokht , Jefreh Maryam Gholamzadeh , Tadayon Mitra , Haghighizadeh Mohammad Hossein 
Published: June 2020

Abstract
Background: Hot flash and night sweat (HF/NS) are the most common complication in menopause that affects the quality of life of women. The present study was conducted with the aim of comparing the effectiveness of the phone with face-to-face counseling based on cognitive-behavioral therapy for vasomotor symptoms of postmenopausal women.Methods: The present study was a randomized clinical trial. In this study, 40 eligible postmenopausal women were randomly assigned to one of face-to-face or phone counseling methods using the block randomization. Six counseling sessions were weekly held for each person and women requested to record their hot flashes and night sweat in a diary. Data were analyzed using chi-square, ANCOVA, and independent t-test.Results: Thirty- six women completed the study. Women in two groups showed a significant improvement in the frequency, severity, and duration of hot flashes and the frequency and severity of night sweats after the intervention (P <0.001). Weekly means of hot flashes and night sweats, decreased after the intervention in both groups (face-to-face group: HF frequency from 31.92±7.98 to 18.83±7.35, HF severity from 2.24±0.28 to 1.21±0.23, HF duration from 4.22±1.17 min to 2.79±0.91min, NS frequency from 2.34±0.31 to 1.21±0.24 and NS severity from 1.70±0.34 to 1.03±0.29 and also in phone counseling group: HF frequency from 33.32±7.77 to 19.53±7.7, HF severity from 2.23±0.24 to 1.20±0.18, HF duration from 4.29±1.23 min to 2.68±0.95min, NS frequency from 2.33±0.31 to 1.14±0.16 and NS severity from 1.59±0.34 to 1.01±0.30). There was no significant difference between groups after the intervention in terms of HF frequency, severity, and duration, as well as NS frequency, and severity (p>0.05). Conclusion: Based on the results of this study, using of face-to-face and phone counseling methods based on cognitive-behavioral therapy had a similar effect on the reducing of frequency, severity and duration of hot flashes as well as the frequency and severity of night sweats. Using phone counseling in women who have difficulty to attend the clinic is recommended.Trial registration number: IRCT20180918041065N1 Website: https://www.irct.ir/login
Genome mining and UHPLC-MS/MS illuminate the specificity of secondary metabolite synthetic gene clusters in Bacillus subtilis NCD-2
Authors: Su Zhenhe , Chen Xiuye , Liu Xiaomeng , Guo Qinggang , Li Shezeng , Lu Xiuyun , Zhang Xiaoyun , Wang PeiPei , Dong Lihong , Zhao Weisong , Ma Ping 
Published: June 2020

Abstract
Background
Bacillus subtilisstrain NCD-2 is anexcellent biocontrol agent against plant soil-borne diseases and shows broad-spectrum antifungal activities. This study aimed to explore all the secondary metabolite synthetic gene clusters and related bioactive compounds in NCD-2. An integrative approach, which coupled genome mining with structural identification technologies using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry (UHPLC-MS/MS), was conducted to interpret the chemical origins of the significant biological activities in NCD-2.
Results
Genome mining revealed that NCD-2 contained nine gene clustershaving predicted functionsinvolving secondary metabolites with bioactive abilities. They encoded six known products-fengycin, surfactin, bacillaene, subtilosin, bacillibactin, and bacilysin-as well as three unknown products.Interestingly, the synthetic gene clusters for surfactin and fengycin showed 83% and 92% amino acid sequence similarity levels with the corresponding productsin Bacillus velezensisstrain FZB42. A further comparison of gene clusters encoding fengycin and surfactinrevealed that strain NCD-2 had lost thefenC and fenDgenes in the fengycinbiosynthetic operon, and that the surfactin synthetic enzyme-related gene srfAB was divided into two parts.Abioinformatics analysis showed that fenEAmay function as fenCD in synthesizing fengycinand that the structure of thisfengycin synthetic gene clusteris likely unique to NCD-2.Five kinds of fengycin,with 26 homologs, and surfactin,with 4 homologs,were detectedfrom strain NCD-2, which indicated the non-typical and unique nature of this fengycin biosynthetic gene cluster.To the best of our knowledge, this is the first report of a non-typical gene cluster related to fengycin synthesis.
Conclusions
The data provide the genetic characteristics of secondary metabolite synthetic gene clusters for fengycinand surfactin in B. subtilis NCD-2, including the unique synthetic mechanism for fengycin, and suggest that bioactive secondary metabolites explain the biological activities of NCD-2.
Lived experiences of Tuberculosis patients and their implications for early Tuberculosis case identification and management in Pastoralist community setting: A Qualitative study in Borena Zone, Oromia Region of Ethiopia
Authors: Adlo Abebe Megerso , Deyessa Negusie , Jarso Godana , Worku Alemayehu 
Published: June 2020

Abstract
Background: Ethiopia has highly diversified population with notable socioeconomic and cultural differences. Regardless of the differences, short course directly observed treatment is uniformly applied all over the country. Evidences are scarce on how well does this uniform approach fits with the pastoral community setting. The purpose of this study was to explore lived experiences of TB patients in the pastoral community under the uniform approach, and their implications to early case identification and management.Method: Qualitative method with phenomenological study design was undertaken to explore lived experiences of TB patients. Patients from all levels of health care (hospital, health center and health post) were included. Experience of both drug susceptible and drug resistant TB patients were documented. Twenty one patients, who consented to in the study, were selected by a convenient sampling method. In-depth interview was conducted using semi-structured interview guide and the interview ended subsequent to information saturation. The interview was audio recorded; and field notes were also taken. Data analysis was done concurrently with the data collection using word processor designed for qualitative text analysis. Inductive Thematic analysis was undertaken to identify key themes.Results: Twenty one patients (eight from hospitals, nine from health centers and four from health posts) were interviewed. Three of the eight hospital patients were on drug resistant tuberculosis (TB) treatment. Sixty two codes, five code categories and three themes emerged from the interviews. The three themes were health system, stigma and discrimination, and socioeconomic problem related experiences. Inaccessibility to health facilities due to scattered settlement and mobility, delay in care seeking TB symptoms, low index of suspecting TB by care providers, fear of stigma and indirect treatment related costs were some of the codes identified.Conclusion: TB patients in the pastoral setting were experiencing multifaceted challenges with the current application of ‘one-size-fits-all’ approach which implied hampered timely case identification and compromised patient management. Therefore, designing context appropriate intervention approach is required to ensure unprejudiced services.
The effect of sevoflurane anesthesia for dental procedure on neurodevelopment in children: a prospective, equivalence, controlled trial
Authors: Zhou Pinping , Zhang Chao , Huang Guijin , Hu Yuan , Ma Wenzhu , Yu Cong 
Published: June 2020

Abstract
Background

Dental procedures under general anesthesia (DGA) was found to improve the oral health-related quality of children's life. However, some parents and pediatricians expressed concern about the neurotoxicity of general anesthesia. The purpose of this trial was to investigate whether DGA in children has an adverse effect on neurodevelopment.
Methods

In this prospective, assessor-masked, controlled, equivalence trial, we recruited 340 children younger than 7 years who were undergoing caries treatment between Feb 1, 2019, and Aug 31, 2019, without factors affecting neurodevelopment. They received either sevoflurane-based general anesthesia or awake-local anesthesia. The Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition Chinese version was used to evaluate the neurodevelopment of children at six months after surgery, and the Full-Scale IQ (FSIQ) was selected as the primary outcome. Predefine the 95% CI of a difference in means within five (1/3 SD) as the equivalence margin.
Results

The outcome data were obtained from 129 children in the general anesthesia group and 144 in the local anesthesia group. The median length of general anesthesia was 130 min (IQR 110–160). There was equivalence in means of FSIQ score between the general anesthesia group and the local anesthesia group (local minus general anesthesia 0.46, 95% CI -2.35 to 1.61). There was no significant difference in FSIQ scores between different age groups and different anesthesia durations. Just the mother's education could affect the primary outcome.
Conclusions

In this trial, prolonged DGA with a sevoflurane-only anesthetic in preschool children, does not adversely affect neurodevelopment at six months after surgery compared with awake-local anesthesia.
Trial registration:

Chinese Clinical Trial Registry, ChiCTR1800015216. Registered Mar 15 2018, http://www.chictr.org.cn/showproj.aspx?proj=24830.
Assessment of nicotine dependence among tobacco users visiting outreach programs in Dharan, Nepal: a cross-sectional study
Authors: Subedi Krishna , Shrestha Ashish , Bhagat Tarakant 
Published: June 2020

Abstract
Background
Nicotine is a highly addictive substance present in tobacco. This study was conducted to assess the prevalence of tobacco use and compare the nicotine dependence among smokers and smokeless tobacco users visiting dental outreach programs of B.P. Koirala Institute of Health Sciences -Dharan, Nepal.
Methods
A cross sectional study was conducted from June 2018 to April 2019. A total of 726 people were selected from participants of dental outreach programs of 6 districts using convenience sampling technique. The data collection was done using semi-structured questionnaire through face to face interview by a single researcher. History of tobacco use and level of nicotine dependency was measured using Nepali translated and validated form of Fagerström Test for Nicotine Dependence for smoking and smokeless. The mean age of the tobacco users was 39.55 ± 15.57 (Range = 19–82 years). Descriptive statistics including the mean, median, percentage, standard deviations and interquartile range were computed. Chi-square test, Fisher’s exact test and odds ratio were calculated where needed.
Results
The overall prevalence of any tobacco use, smoking form, smokeless and both form was found to be 32.8%, 14.9%, 14.3% and 3.6% respectively. Nicotine dependence (moderate and severe) was found in 80% of smokeless tobacco users and 48% of smokers. Among the smokeless tobacco users nicotine dependency was found to be more with female gender (Odds ratio = 4.98, 95%CI = 1.41–17.69, p = 0.01), increase in duration of tobacco use with every 10 years, low socioeconomic status (Odds ratio = 2.75, 95%CI = 1.02–7.40, p = 0.04), married, not using alcohol. Among smokers nicotine dependency was found to be significantly higher with more than 30 years of duration (Odds ratio = 3.35, 95% CI = 1.42–7.92, p = 0.005).
Conclusions
The study concluded that prevalence of tobacco consumption and nicotine dependence was high among the people visiting dental outreach programs. This study incorporated both smoking and smokeless tobacco users. It is high time to develop a policy to control tobacco use along with creating tobacco cessation centers. Tobacco control program are basically focusing on smoking. However, it is very necessary to incorporate in policy level to control smokeless tobacco along with smoking. Tobacco cessation centers will obviously help to quit tobacco among the tobacco users.
Patients with obesity use of activity monitors when attending a weight-loss programme—a qualitative study
Authors: Følling Ingrid Sørdal , Oldervoll Line , Hilmarsen Christina , Ersfjord Ellen M I 
Published: June 2020

Abstract
Background: Obesity is a major health concern in western countries. In Norway, patients with obesity can attend weight-loss programmes, which focus on changes in dietary and physical activity habits. Use of self-monitoring is advocated when changing dietary and physical activity habits for adults with obesity. This study aimed to explore the experiences of patients with obesity who used activity monitors while attending a weight-loss program.Methods: Patients with body mass index (BMI) > 35 kg/m2 with weight related comorbidities or a BMI > 40 kg/m2 referred to an intermittent weight-loss programme were recruited into this study. They were introduced to one of three different activity monitors, Fitbit ZipTM, Mio FuseTM, or Mio SliceTM. Semi-structured interviews were performed with patients six months into the weight-loss programme. Thematic analysis was applied when analysing the data.Results: Of the 29 informants (aged 21 to 66 years) interviewed, 59% were female. Their experience with activity monitors was related to their adherence to the weight-loss programme. Two main themes emerged from the informants stories: 1. “Activity monitors visualize proof of effort or failure to change health habits”. 2. “Activity monitors act as a positive or negative enforcer when incorporating change”.Conclusions: Using activity monitors either strengthens or undermines patients’ attempts to change health habits when attending a weight-loss program. Our findings suggest a need for more individualized weight-loss programmes for patients with obesity.Trial Registration: The study was registered in ClinicalTrials.gov on July 7 2016, with the registration number NCT02826122 and URL: https://clinicaltrials.gov/ct2/show/NCT02826122?term=NCT02826122&draw=2&rank=1.