bluuebunny/crossref_metadata_2025_split huggingface dataset:
General and reproductive health among women after an episode of severe maternal morbidity: Results from the COMMAG study
Authors: Ferreira Elton C. , Costa Maria L. , Pacagnella Rodolfo C. , Silveira Carla , Andreucci Carla B. , Zanardi Dulce M. , Santos Juliana P. , Angelini Carina R. , Souza Renato T. , Parpinelli Mary A. , Sousa Maria H. , Cecatti Jose G. 
Published: April 2020

AbstractObjectiveTo assess general and reproductive health in women after severe maternal morbidity (SMM).MethodsA retrospective cohort study was performed at a tertiary maternity hospital. Women with SMM criteria who delivered during 2008–2012 were included in the SMM group. The control group included a random sample of women without SMM delivering in the same year of cases. Both groups were compared regarding sociodemographic/obstetric characteristics, general and reproductive health, using χ2, Yates χ2, Fisher exact, and Mann‐Whitney tests.ResultsThere were 315 women in the SMM group and 323 women in the control group. The SMM group was older and had a history of more medical conditions (hypertension, diabetes, obesity), cesarean deliveries, preterm births, and perinatal deaths. Breastfeeding was negatively affected in these women, as was fertility. The SMM group had a non‐significant trend of fewer children after index pregnancy, had new complications in subsequent pregnancies, and required specialized medical care, besides higher risk of death.ConclusionWomen experiencing SMM are at higher risk of general and reproductive health problems after pregnancy, including risk of death. Therefore, their surveillance and follow‐up should continue beyond 42 days postpartum, highlighting the importance of more specialized health care.
Introduction to the special section: The development of infant mental health home visiting in Michigan state government
Authors: Tableman Betty , Ludtke Mary 
Published: April 2020

ABSTRACTThis issue of the Infant Mental Health Journal presents the first papers from a tripartite evaluation study of state‐sponsored infant mental health home visiting program in Michigan, United States. This series of studies has been led by Kate Rosenblum PhD and Maria Muzik MD, Department of Psychiatry, the University of Michigan and faculty from the Michigan Collaborative for Infant Mental Health Research for the State of Michigan, Department of Health and Human Services, Mental Health Services for Children, to fulfill the requirements of state legislation (State of Michigan Act No. 291, Public Acts of 2013) that required that all home visiting programs meet certain requirements to be established as an evidence‐based practice. In this introduction, we provide a historical context for the delivery of infant mental health home visiting through the community mental health system in the state of Michigan.
Is deflation costly after all? The perils of erroneous historical classifications
Authors: Kaufmann Daniel 
Published: April 2020

SummaryI estimate average economic activity during periods of inflation and deflation while accounting for measurement errors in 19th century prices. These measurement errors lead to underestimation (overestimation) of economic activity during periods of inflation (deflation). By exploiting multiple deflation indicators, it is possible to recover the true relationship; the shortfall of US industrial production growth during periods of deflation ranges from −4.5 pp to −7.6 pp, instead of −2 pp. I also find a negative relationship between deflation and real activity in the UK. I then examine the cross‐country variation in the estimates for eleven countries. The patterns are consistent with stronger biases for countries with more serious measurement errors in prices.
Spatial autocorrelation analysis on two‐dimensional images of Mueller matrix for diagnosis and differentiation of cervical precancer
Authors: Zaffar Mohammad , Pradhan Asima 
Published: April 2020

AbstractThe spatial autocorrelation and correlation map of amplitude and phase anisotropy along with depolarization parameter from the stroma of uterine cervix utilizing their Mueller matrix (MM) images have been reported for early diagnosis of cervical cancer and differentiation of precancerous stages. The comparative results of the evaluation of the spatial autocorrelation over MM images of optically anisotropic collagen structures from normal and various grades of cervical precancer reflect significant alterations which are correlated with the pathological changes. The spatially varying polarizance from different region of anisotropic stromal region gets correlated within a given spatial lag during the precancerous changes. The diattenuation governing elements M12, M13 and M14 clearly discriminate normal and various grades of precancerous cervical tissue through their autocorrelation profile and correlation map. Evaluation of autocorrelation of spatially varying linear birefringence and linear‐45 birefringence characterized by MM elements M34 and M43 and M24 and M42 are not found to differ between the precancer grades, indicating that these changes may be arising from highly directional collagen network while the changes displayed by MM elements M23 and M32 faithfully represent that the chirality of the stromal region is compromised as the cervical cancer evolves and only one type of nature dominates.
FAK Promotes Early Osteoprogenitor Cell Proliferation by Enhancing mTORC1 Signaling
Authors: Qi Shuqun , Sun Xiumei , Choi Han Kyoung , Yao Jinfeng , Wang Li , Wu Guomin , He Yun , Pan Jian , Guan Jun-Lin , Liu Fei 
Published: April 2020

ABSTRACT
Focal adhesion kinase (FAK) has important functions in bone homeostasis but its role in early osteoprogenitor cells is unknown. We show herein that mice lacking FAK in Dermo1-expressing cells exhibited low bone mass and decreased osteoblast number. Mechanistically, FAK-deficient early osteoprogenitor cells had decreased proliferation and significantly reduced mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling, a central regulator of cell growth and proliferation. Furthermore, our data showed that the pharmacological inhibition of FAK kinase-dependent function alone was sufficient to decrease the proliferation and compromise the mineralization of early osteoprogenitor cells. In contrast to the Fak deletion in early osteoprogenitor cells, FAK loss in Col3.6 Cre-targeted osteoblasts did not cause bone loss, and Fak deletion in osteoblasts did not affect proliferation, differentiation, and mTORC1 signaling but increased the level of active proline-rich tyrosine kinase 2 (PYK2), which belongs to the same non–receptor tyrosine kinase family as FAK. Importantly, mTORC1 signaling in bone marrow stromal cells (BMSCs) was reduced if FAK kinase was inhibited at the early osteogenic differentiation stage. In contrast, mTORC1 signaling in BMSCs was not affected if FAK kinase was inhibited at a later osteogenic differentiation stage, in which, however, the concomitant inhibition of both FAK kinase and PYK2 kinase reduced mTORC1 signaling. In summary, our data suggest that FAK promotes early osteoprogenitor cell proliferation by enhancing mTORC1 signaling via its kinase-dependent function and the loss of FAK in osteoblasts can be compensated by the upregulated active PYK2. © 2020 American Society for Bone and Mineral Research.
Abstract

Schematic model of the differential roles of FAK in the cells of osteoblast lineage. The model depicts the mechanisms of FAK action at three distinct stages of osteoblast lineage in which the roles of FAK have been addressed by genetic and pharmacological approaches as well as the respective Cre transgenes used to target Fak, including Dermo1-Cre (this study), Osterix-Cre,(10)Col3.6-Cre (this study), and Col2.3-Cre.(9) Red ↔ indicates that the loss of FAK in osteoblasts can be compensated by the upregulated active PYK2.
Complete active space analysis of a reaction pathway: Investigation of the oxygen–oxygen bond formation
Authors: Han Ruocheng , Luber Sandra 
Published: April 2020

AbstractWater nucleophilic attack is an important step in water oxidation reactions, which have been widely studied using density functional theory (DFT). Nevertheless, a single‐determinant DFT picture may be insufficient for a deeper insight into the process, in particular during the oxygen–oxygen bond formation. In this work, we use complete active space self‐consistent field calculations and describe an approach for a complete active space analysis along a reaction pathway. This is applied to the water nucleophilic attack at a Ru‐based catalyst, which has successfully been used for efficient water oxidation and in silico design of new water oxidation catalysts recently.
Synthesis of dehydroepiandrosterone by co‐immobilization of keto reductase and glucose dehydrogenase
Authors: Zhang Junliang , Pu Tian , Xu Ying , Huang Junhai , Chen Daijie , Shao Lei 
Published: April 2020

AbstractBACKGROUNDDehydroepiandrosterone (DHEA), a steroid hormone drug and a precursor of other steroid hormone drugs, is industrially important. We aimed to establish the co‐immobilization of keto reductase and glucose dehydrogenase by a crosslinked enzyme aggregate (co‐CLEA) and to determine whether co‐CLEAs can improve DHEA yield compared with crude enzymes.RESULTSHeterologous expression plasmids containing genes coding for keto reductase or glucose dehydrogenase were constructed. The size of each of these proteins was determined using SDS‐PAGE and purification on a nickel column. After optimizing the expression conditions for these two enzymes, the co‐CLEAs were prepared with 80% acetone as a precipitant and 0.005% glutaraldehyde as a crosslinking agent. Compared with the crude enzyme solutions, the co‐CLEAs showed better thermal stability and pH stability. After six cycles of use, the co‐CLEAs still showed 70% (keto reductase) and 46% (glucose dehydrogenase) of their initial activities. After four reaction cycles, the accumulated production of DHEA using the co‐CLEAs reached 183 g L–1.CONCLUSIONSThis research provides a possible strategy for the production of clinically useful DHEA through co‐immobilization. © 2020 Society of Chemical Industry
Arc‐disjoint strong spanning subdigraphs of semicomplete compositions
Authors: Bang‐Jensen Jørgen , Gutin Gregory , Yeo Anders 
Published: April 2020

AbstractA strong arc decomposition of a digraph is a decomposition of its arc set into two disjoint subsets and such that both of the spanning subdigraphs and are strong. Let be a digraph with vertices and let be digraphs such that has vertices . Then the composition is a digraph with vertex set and arc set
We obtain a characterization of digraph compositions which have a strong arc decomposition when is a semicomplete digraph and each is an arbitrary digraph. Our characterization generalizes a characterization by Bang‐Jensen and Yeo (2003) of semicomplete digraphs with a strong arc decomposition and solves an open problem by Sun, Gutin, and Ai (2019) on strong arc decompositions of digraph compositions in which is semicomplete and each is arbitrary. Our proofs are constructive and imply the existence of a polynomial algorithm for constructing a strong arc decomposition of a digraph , with semicomplete, whenever such a decomposition exists.
Topologically 4‐chromatic graphs and signatures of odd cycles
Authors: Simons Gord , Tardif Claude , Wehlau David 
Published: April 2020

AbstractWe investigate group‐theoretic “signatures” of odd cycles of a graph, and their connections to topological obstructions to 3‐colourability. In the case of signatures derived from free groups, we prove that the existence of an odd cycle with trivial signature is equivalent to having the coindex of the hom‐complex at least 2 (which implies that the chromatic number is at least 4). In the case of signatures derived from elementary abelian 2‐groups we prove that the existence of an odd cycle with trivial signature is a sufficient condition for having the index of the hom‐complex at least 2 (which again implies that the chromatic number is at least 4).
Hospital‐acquired rotavirus acute gastroenteritis in 10 consecutive seasons in Umbria (Italy)
Authors: Camilloni Barbara , Alunno Anna , Nunzi Emilia , Sarnari Laura , Ianiro Giovanni , Monini Marina 
Published: April 2020

AbstractGroup A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in young (aged <5 years) children. Several studies showed that RVA is one of the main cause of nosocomial gastroenteritis in hospitalized pediatric population worldwide, with an incidence ranging from 8 to 33 cases per 100 hospitalized children. Nosocomial infections, in which AGE symptoms develop at least 2 days after admission, may severely affect children already admitted to hospital for other causes. This study aimed to define the trends of the RVA genotypes through statistical analysis of the data obtained by the rotavirus surveillance in Umbria in 10 consecutive seasons, from 2007‐2008 to 2016‐2017, with update information on hospital‐acquired RVA AGE. During RVA gastroenteritis surveillance in Umbria (Italy) in 2007 to 2017, a total of 741 RVA positive faecal samples were collected from children hospitalized with AGE, and RVA strains were genotyped following standard EuroRotaNet protocols. Of the 741 analyzed samples, 75 (10%) were reported to be hospital‐acquired. Comparing the distributions of the RVA genotypes circulating in the community or associated with nosocomial infections, we observed a different distribution of genotypes circulating inside the hospital wards, with respect to those observed in the community except in 2010 to 2011, 2011 to 2012, and 2012 to 2013 when G1P[8], G4P[8] and the novel strain G12P[8] caused a large community‐ and hospital‐acquired outbreak. Of the 741 analyzed samples, 75 (10%) were reported to be hospital‐acquired. Comparing the distributions of the RVA genotypes circulating in the community or associated with nosocomial infections, we observed a different distribution of genotypes circulating inside the hospital wards, with respect to those observed in the community except in 2010 to 2011, 2011 to 2012, and 2012 to 2013 when G1P[8], G4P[8], and the novel strain G12P[8] caused a large community‐ and hospital‐acquired outbreak. The information from this study will be useful to implement guidelines for preventing nosocomial RVA AGE, which should include an improved management of the hospitalized patients and an increase in vaccination coverage.
Determination of potential biotin interference on accuracy of results of serologic assays for various viral hepatitis markers
Authors: Kodani Maja , Poe Amanda , Drobeniuc Jan , Mixson‐Hayden Tonya 
Published: April 2020

AbstractBiotin taken orally can interfere with some diagnostic immunoassays, including those for thyroid hormones, ferritin, and markers of infectious disease. Assays affected are ones that use streptavidin‐biotin in their design. The goal of our study was to examine the effect of biotin concentrations of up to 1200 ng/mL on three serological assays performed on VITROS 3600 system, Immunoglobulin M (IgM) antibodies to hepatitis A virus (anti‐HAV), total anti‐HAV, and IgM antibodies to hepatitis B virus core antigen (anti‐HBc), by spiking serum samples with variable amounts of biotin. No false‐negative results were generated with either concentration of biotin for total anti‐HAV (65/65). Likewise, biotin caused no false‐positive IgM anti‐HAV results (59/59) with either concentration of biotin; however, 6.7% false negativity was found for IgM anti‐HAV when samples were spiked with 1200 ng/mL of biotin. Conversely, 100% false positivity (30/30) was produced by biotin interference in total anti‐HAV negative specimens with both concentrations of biotin. False negativity rate was 87.5% in IgM anti‐HBc positive samples when biotin levels were at 1200 ng/mL. These data show that individuals taking biotin‐containing supplements may test false‐positive in some serologic assays using streptavidin‐biotin chemistries. Further studies are warranted to determine the extent of biotin interference resulting in false‐positive and negative results and their impact, if any, on surveillance and diagnostic settings.
The passion bug: How and when do leaders inspire work passion?
Authors: Ho Violet T. , Astakhova Marina N. 
Published: April 2020

SummaryDrawing from signaling theory, we propose a work passion transfer model where leaders' passion is transmitted to employees through the former's leadership style and is contingent on employees' perceived importance of performance to self‐esteem (IPSE). Data from 201 supervisor–employee dyads from the health‐care industry show that leaders' harmonious passion led to employees' harmonious passion through charismatic leadership, whereas contingent reward leadership accounted for the transfer of obsessive passion; IPSE did not play a moderating role for either form of passion. Results from a supplementary study further reveal that the link between leadership and employee passion operated through employees' perception of leader passion and that employees' IPSE accentuated for the relationship between perceived leader obsessive passion and employees' obsessive passion. This study advances research in work passion, leadership, and signaling theory and provides important implications for managerial practice.
Expression of alarmins in a murine rotator cuff tendinopathy model
Authors: Zhang Ying , Deng Xiang‐Hua , Lebaschi Amir H. , Wada Susumu , Carballo Camila B. , Croen Brett , Ying Liang , Rodeo Scott A. 
Published: April 2020

AbstractThe aim of this study was to investigate the presence of alarmins in a novel murine rotator cuff tendinopathy model. Alarmins have been described as essential early activators of an immune response to tissue damage. Subacromial impingement was induced in both shoulders of 37 male C57Bl/6 mice by placement of a small metal clip in the subacromial space. Animals were allocated to different time points up to 6 weeks. The morphology and cellularity of the supraspinatus tendon were evaluated by hematoxylin‐eosin staining, alcian blue, and picrosirius red. The expression and localization of alarmins interleukin‐33 (IL‐33), c (HMGB1), hypoxia‐inducible factor‐1 subunit α (HIF1α), and S100A9 were evaluated by immunohistochemical staining and quantitative polymerase chain reaction. The percentage of positively stained cells with HMGB1 and IL‐33 was significantly increased in the impingement group at 1w, 4w, and 6w. HIF1α staining was higher in the impingement group at 1w and 6w compared with the control group. HMGB1 gene expression was higher in the 5d impingement group and 6w impingement group. The gene expression of HIF1α was upregulated at all‐time points in the impingement group (5d, 2w, 4w, and 6w). The expression of the S100A9 gene was also upregulated in the 5d impingement group. This is the first study to demonstrate the involvement of alarmins in the early phase of tendinopathy using a reproducible animal model. Alarmins may play an important role in the early phases of the development of tendinopathy They may represent potential therapeutic targets for treatment of tendinopathy.
Evaluation of mental health training for community pharmacy staff members and consumers
Authors: Shams Sara , Hattingh Hendrika Laetitia 
Published: April 2020

AbstractBackgroundCommunity pharmacy staff in rural and remote areas need to have the skills to recognise mental health signs and symptoms, provide support and appropriate advice.AimsTo evaluate the impact of Mental Health First Aid (MHFA) training through collaborative sessions attended by pharmacy staff and community members.MethodsPharmacy staff, alongside members of the local farming community, attended collaborative MHFA training in four Queensland towns. This study evaluated the training through pre‐ and post‐training questionnaires and email feedback following practice application of skills.ResultsThirty‐two pharmacy staff and 14 community members participated in both pre‐ and post‐ questionnaires; 10 males and 36 females varying in age between 18 and 65 with the majority (26, 72.2%) aged 30–49 years. Participants’ understanding of the need to ask a person directly about suicide changed significantly through the training. The pre‐and post‐course surveys demonstrated a difference in knowledge of both the consumers and pharmacy staff members. Community members’ perception about how pharmacy staff can assist with mental health issues changed significantly and pharmacy staff reported an increase in confidence to approach consumers regarding their mental health. Qualitative feedback from consumers and pharmacy staff 8–12 weeks following the training was positive.ConclusionPharmacy staff members are well placed to provide mental health support to farming communities. A collaborative mental health training approach in rural and remote areas that involved pharmacy staff and local community members showed improved knowledge, skills and collaboration between staff and consumers. This approach could easily be adapted to other contexts.
Climate control on stacked paleosols in the Pleistocene of the Po Basin (northern Italy)
Authors: Bruno Luigi , Marchi Michela , Bertolini Ilaria , Gottardi Guido , Amorosi Alessandro 
Published: April 2020

ABSTRACTPaleosols are recurrent features in alluvial successions and provide information about past sedimentary dynamics and climate change. Through sedimentological analysis on six sediment cores, the mud‐dominated succession beneath the medieval ‘Two Towers’ of Bologna was investigated down to 100 m depth. A succession of weakly developed paleosols (Inceptisols) was identified. Four paleosols (P1, P2, P3 and PH) were radiocarbon‐dated to 40–10 cal ka bp. Organic matter and CaCO3 determinations indicate low groundwater levels during soil development, which spanned periods < 5 ka. The development and burial of soils, which occurred synchronously in the Bologna region and in other sectors of the Po Plain, are interpreted to reflect climatic and eustatic variations. Climatic oscillations, at the scale of the Bond cycles, controlled soil development and burial during Marine Isotope Stage (MIS) 3 (P1 and P2). Rapid sea‐level oscillations probably induced soil development at the MIS 3/2 transition (P3) and favored burial of PH after 10 ka bp. Weakly developed paleosols in alluvial successions can provide clues to millennial‐scale climatic and environmental variations. In particular, the paleosol‐bearing succession of the Po Plain represents an unprecedent record of environmental changes across the Late Pleistocene (MIS 3 and 2) in the Mediterranean region.
Raman spectroscopic analysis and imaging in two cases of benign cementoma: Comparison with dental and bone tissues
Authors: Chappard Daniel , Guillaume Bernard , Teman Gil , Kün‐Darbois Jean‐Daniel 
Published: April 2020

AbstractBenign cementoma is a rare tumor of the jaws whose origin is still debating. The tumor may derive from the dental cementum or the bone surrounding the socket. We have studied the profiles of enamel, dentine, and cementum from normal teeth and alveolar and cortical bone of the mandible. Raman spectroscopy was used to compare the spectra of these tissues embedded in poly(methylmethacrylate) from 300 to 3,100 cm−1. The degree of mineralization, carbonate‐to‐phosphate ratio, and crystallinity were derived. Tissue hydration was determined by measuring the ratio of the 813 cm−1 band of methacrylate to the 960 cm−1 band of phosphate. Raman spectroscopic imaging was obtained on large tissue areas with a bandwidth from 500 to 1,620 cm−1. Maps of the different peak ratio were obtained to analyze the mineral and organic phases (crystallinity, carbonate‐to‐phosphate, degree of mineralization) together with tissue hydration. Cementomas appeared highly heterogeneous, and their matrix possessed histological and spectroscopic characteristics that resemble highly calcified woven bone with a poor organization of the hydroxyapatite crystals.