bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two PVTOLs cooperative slung‐load transport control based on passivity
Authors: Cariño Escobar Jossué , Lozano Rogelio , Bonilla Estrada Moisés 
Published: November 2019

AbstractThis work addresses the problem of two unmanned aerial vehicles (UAVs) transporting a slung‐load on a plane. The vehicles presented are a simplified version of the classical planar vertical take‐off and landing (PVTOL). The proposed solution implements a decentralized control scheme based on the concept of passivity where there is no explicit communication between agents. This is accomplished by taking advantage of the physical connection between the agents and the load. In contrast with similar control algorithms based on force control, like impedance filters, the objective is to drive the system into a state of minimal energy. In addition to this, the presented control strategy differs from other passivity based methods, like an interconnection and damping assignment passivity‐based control, in that the method can also be used to accommodate more complex control strategies that do not necessarily depend on the energy of the system.
Self‐Powered Sensor Based on Bionic Antennae Arrays and Triboelectric Nanogenerator for Identifying Noncontact Motions
Authors: Wang Fan , Ren Zewei , Nie Jinhui , Tian Jingwen , Ding Yafei , Chen Xiangyu 
Published: November 2019

AbstractThe sensor devices based on triboelectric nanogenerator (TENG) have been proved to have both high sensitivity and good self‐powered capability. Inspired by the cockroach antennae, a bionic‐antennae‐array (BAA) sensor based on the working principle of TENG is proposed for identifying the noncontact motions and a data processing module is specially designed for outputting electrostatic signal to the microcontroller unit (MCU). Based on the amplifying effect of antennae array, the detected maximum distance by this BAA sensor can reach 180 mm with a displacement resolution of 1 mm and maximum sensitivity of about 5.6 V mm−1 (at approaching angle of 90°). The influences of several critical factors, such as approaching angle, motion velocity, and target materials, to the performance of this BAA sensor are systematically studied. Meanwhile, the BAA sensor is integrated with proximity switch, intelligent robot, and mobile vehicles for realizing the function of motion alarming and obstacle detecting. The high sensitivity and the easy fabrication process of this TENG‐based BAA sensor show great application potentials in the field of industrial robotics, human–machine interactions, artificial intelligence, etc.
Multi‐Functional Controllable Memory Devices Applied for 3D Integration Based on a Single Niobium Oxide Layer
Authors: Chen Ao , Ma Guokun , Zhang Ziqi , Lin Chih‐Yang , Lin Chun‐Chu , Chang Ting‐Chang , Tao Li , Wang Hao 
Published: November 2019

AbstractTo achieve the highest integration density, a one‐selector one‐resistor (1S1R) structure is essential because of its smallest feature size in crossbar arrays. However, the complexity of structure and poor stability of the 1S1R property has seriously hampered its development. A multi‐functional controllable device with simple Pt/NbOx/TiN structure is fabricated and exhibits excellent 1S1R characteristics and threshold switching properties, which is suitable for integration due to the reduced leakage current. Meanwhile, two modes of 1S1R characteristics are found and discussed in detail, which is beneficial to understand the degeneration of 1S1R property. Furthermore, finite element analysis is utilized to analyze and provide further support for the multi‐behaviors. A multi‐functional device is demonstrated and the multi‐behavior mechanisms are explained, which is helpful to promote the application of 3D storage technology.
An overview of health issues and development in a large clinical cohort of children with Angelman syndrome
Authors: Bindels‐de Heus Karen G. C. B. , Mous Sabine E. , ten Hooven‐Radstaake Maartje , van Iperen‐Kolk Bianca M. , Navis Cindy , Rietman André B. , ten Hoopen Leontine W. , Brooks Alice S. ,   ENCORE Expertise Center for AS, Elgersma Ype , Moll Henriëtte A. , de Wit Marie‐Claire Y. 
Published: November 2019

AbstractThis study presents a broad overview of health issues and psychomotor development of 100 children with Angelman syndrome (AS), seen at the ENCORE Expertise Center for AS in Rotterdam, the Netherlands. We aimed to further delineate the phenotype of AS, to evaluate the association of the phenotype with genotype and other determinants such as epilepsy and to get insight in possible targets for intervention. We confirmed the presence of a more severe phenotype in the 15q11.2‐q13 deletion subtype. Novel findings were an association of (early onset of) epilepsy with a negative effect on development, a high occurrence of nonconvulsive status epilepticus, a high rate of crouch gait in the older children with risk of deterioration of mobility, a relatively low occurrence of microcephaly, a higher mean weight for height in all genetic subtypes with a significant higher mean in the nondeletion children, and a high occurrence of hyperphagia across all genetic subtypes. Natural history data are needed to design future trials. With this large clinical cohort with structured prospective and multidisciplinary follow‐up, we provide unbiased data on AS to support further intervention studies to optimize outcome and quality of life of children with AS and their family.
Delayed appearance of 3‐methylglutaconic aciduria in neonates with early onset metabolic cardiomyopathies: A potential pitfall for the diagnosis
Authors: Baban Anwar , Adorisio Rachele , Corica Bernadette , Rizzo Cristiano , Calì Federica , Semeraro Michela , Taurisano Roberta , Magliozzi Monia , Carrozzo Rosalba , Parisi Francesco , Dallapiccola Bruno , Vaz Frédéric M. , Drago Fabrizio , Dionisi‐Vici Carlo 
Published: November 2019

AbstractInfantile onset cardiomyopathies are highly heterogeneous with several phenocopies compared with adult cardiomyopathies. Multidisciplinary management is essential in determining the underlying etiology in children's cardiomyopathy. Elevated urinary excretion of 3‐methylglutaconic acid (3‐MGA) is a useful tool in identifying the etiology in some metabolic cardiomyopathy. Here, we report the delayed appearance of 3‐MGA‐uria, between 6 and 18 months in three patients (out of 100 childhood onset cardiomyopathy) with neonatal onset cardiomyopathy, secondary to TMEM70 mutations and TAZ mutations (Barth syndrome), in whom extensive metabolic investigations, performed in the first weeks of life, did not display 3‐MGA‐uria. Serial retrospective evaluations showed full characteristic features of TMEM70 and TAZ mutations (Barth syndrome) in these three patients, including a clearly abnormal monolysocardiolipin/cardiolipin ratio in the two Barth syndrome patients. Serially repeated metabolic investigations finally discovered the 3‐MGA‐uria biomarker in all three patients between the age of 6 and 18 months. Our observation provides novel insights into the temporal appearance of 3‐MGA‐uria in TMEM70 and TAZ mutations (Barth syndrome) and focus the importance of multidisciplinary management and careful evaluation of family history and red flag signs for phenocopies in infantile onset cardiomyopathies.
A Supramolecular Trap to Increase the Antibacterial Activity of Colistin
Authors: Liao Fang‐Hsuean , Wu Te‐Haw , Yao Chun‐Nien , Kuo Shu‐Chen , Su Chun‐Jen , Jeng U‐Ser , Lin Shu‐Yi 
Published: November 2019

AbstractA strong interaction between colistin, a last‐resort antibiotic of the polymyxin family, and free lipopolysaccharide (LPS, also referred to as endotoxin), released from the Gram‐negative bacterial (GNB) outer membrane (OM), has been identified that can decrease the antibacterial efficacy of colistin, potentially increasing the dose of this antibiotic required for treatment. The competition between LPS in the GNB OM and free LPS for the interaction with colistin was prevented by using a supramolecular trap to capture free LPS. The supramolecular trap, fabricated from a subnanometer gold nanosheet with methyl motifs (SAuM), blocks lipid A, preventing the interaction between lipid A and colistin. This can minimize endotoxemia and maximize the antibacterial efficacy of colistin, enabling colistin to be used at lower doses. Thus, the potential crisis of colistin resistance could be avoided.
Molekül‐induzierte Radikalbildung – eine Neubewertung
Authors: Sandhiya Lakshmanan , Jangra Harish , Zipse Hendrik 
Published: November 2019

AbstractRadikalkettenreaktionen werden normalerweise durch die thermische oder photochemische Aktivierung von Radikalinitiatoren, durch die photochemische Aktivierung der Substrate selbst oder durch gezielte Redoxprozesse eingeleitet. Woher Radikale in der Abwesenheit dieser Initiierungsstrategien kommen, ist oft wenig bekannt und wird daher auf das Vorhandensein unbekannter Verunreinigungen zurückgeführt. In dieser Situation bieten sich Molekül‐induzierte Radikalbildungs (MIRF)‐Reaktionen als wohldefinierte alternative Initiierungsmechanismen an. In ihrer allgemeinsten Definition reagieren in MIRF‐Reaktionen zwei geschlossenschalige Moleküle unter Bildung eines Radikalpaars oder Diradikals. Der genaue Charakter dieses Prozesses hängt von den σ‐ oder π‐Bindungen ab, die an der MIRF‐Reaktion beteiligt sind, und dieser Kurzaufsatz konzentriert sich besonders auf Reaktionen, in denen zwei σ‐Bindungen in zwei Radikale und ein geschlossenschaliges Produkt umgewandelt werden.
Stimuli‐Responsive Biomolecule‐Based Hydrogels and Their Applications
Authors: Vázquez‐González Margarita , Willner Itamar 
Published: November 2019

AbstractThis Review presents polysaccharides, oligosaccharides, nucleic acids, peptides, and proteins as functional stimuli‐responsive polymer scaffolds that yield hydrogels with controlled stiffness. Different physical or chemical triggers can be used to structurally reconfigure the crosslinking units and control the stiffness of the hydrogels. The integration of stimuli‐responsive supramolecular complexes and stimuli‐responsive biomolecular units as crosslinkers leads to hybrid hydrogels undergoing reversible triggered transitions across different stiffness states. Different applications of stimuli‐responsive biomolecule‐based hydrogels are discussed. The assembly of stimuli‐responsive biomolecule‐based hydrogel films on surfaces and their applications are discussed. The coating of drug‐loaded nanoparticles with stimuli‐responsive hydrogels for controlled drug release is also presented.
Isocyanurate transformation induced healing of isocyanurate–oxazolidone polymers
Authors: Zhang Lisha , Lin Jiajun , Sodano Henry A. 
Published: November 2019

ABSTRACTIsocyanurate–oxazolidone (ISOX) polymers have been reported as a novel, intrinsically self‐healable thermoset, and their healing mechanism under the effect of nucleophiles, such as tertiary amines and pyridines during polymerization, is thoroughly investigated in this study. This work provides evidence that the healing behavior of the polymers results part from the transformation of isocyanurate to oxazolidone on the fracture surfaces of the ISOX polymers at elevated temperatures. The isocyanurate transformation is characterized by chemical composition of the ISOX polymers before and after a predetermined healing procedure, through a combination characterization of Fourier transform infrared spectroscopy and carbon nuclear magnetic resonance spectroscopy. From the chemical composition of the ISOX polymers, an increased oxazolidone fraction is observed after the healing event, which verifies the hypothesized healing mechanism. By correlating the change in oxazolidone fraction in the polymers during the healing event, with the corresponding healing performance of the polymers, healing efficiencies of the polymers are shown to be inversely proportional to the ratio of oxazolidone to isocyanurate in the polymers. The transformation to oxazolidone is also shown to be dependent on two variables, nucleophilicity of the polymerization catalyst and duration of the postcure. The isocyanate and epoxide polymerization mechanism in the presence of nucleophiles is also investigated to explain the effect of the catalyst nucleophilicity on the chemical composition as well as the healing performance of the ISOX polymers. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48698.
Data‐driven adaptive terminal sliding mode control with prescribed performance
Authors: Hou Mingdong , Wang Yinsong 
Published: November 2019

AbstractWe propose a novel data‐driven model‐free adaptive terminal sliding mode control (SMC) for a class of discrete nonlinear systems with perturbations in which tracking error constraints are taken into account in improving tracking accuracy. The goal of this design is that the tracking error trajectory is maintained within the prescribed convergence region which is defined by the performance function, while the disturbances exist. In explaining the advantage of this proposed control scheme, at first, by theoretical calculation, it is proved theoretically that the quasi‐sliding mode can be achieved in a limited time under the specified tracking performance. Furthermore, comparative investigation results are given to validate the effectiveness of the proposed control scheme. Simulation results show that the proposed strategy is superior to model‐free adaptive control, model‐free adaptive terminal SMC, and data‐driven adaptive SMC with prescribed performance control algorithms in terms of tracking accuracy and response speed, which demonstrates the efficiency of the proposed scheme.
Robust asset allocation with conditional value at risk using the forward search
Authors: Grossi Luigi , Laurini Fabrizio 
Published: November 2019

AbstractThe well‐known Markowitz approach to portfolio allocation, based on expected returns and their covariance, seems to provide questionable results in financial management. One motivation for the pitfall is that financial returns have heavier than Gaussian tails, so the covariance of returns, used in the Markowitz model as a measure of portfolio risk, is likely to provide a loose quantification of the effective risk. Additionally, the Markowitz approach is very sensitive to small changes in either the expected returns or their correlation, often leading to irrelevant portfolio allocations. More recent allocation techniques are based on alternative risk measures, such as value at risk (VaR) and conditional VaR (CVaR), which are believed to be more accurate measures of risk for fat‐tailed distributions. Nevertheless, both VaR and CVaR estimates can be influenced by the presence of extreme returns. In this paper, we discuss sensitivity to the presence of extreme returns and outliers when optimizing the allocation, under the constraint of keeping CVaR to a minimum. A robust and efficient approach, based on the forward search, is suggested. A Monte Carlo simulation study shows the advantages of the proposed approach, which outperforms both robust and nonrobust alternatives under a variety of specifications. The performance of the method is also thoroughly evaluated with an application to a set of US stocks.
Identifying high‐density regions of pests within an orchard
Authors: He Fei , Jeske Daniel R. , Grafton‐Cardwell Elizabeth 
Published: November 2019

AbstractThis paper proposes a statistical method for identifying high‐density regions of pests, so‐called hot spots, within an orchard. Our method uses scanning windows to search for clusters of high counts within the sampled data. The proposed method enables a localized alternative for treatment that could be faster, less costly, and more environmentally friendly. R code that implements the hot spot identification method is provided as online supplementary material. The method is illustrated through simulated examples and a real data on counts of cottony cushion scales from an orchard.
Change process in systemic therapy: A qualitative investigation
Authors: Dourdouma Anna , Gelo Omar Carlo Gioacchino , Moertl Kathrin 
Published: November 2019

AbstractThis study addresses the process of therapeutic change in individuals who received systemic therapy. This study is an exploratory qualitative study based on the client's perceptions and therapeutic experiences. The sample included 10 clients who had completed their therapy with systemic therapists. The method used for the collection of the data was semi‐structured interviews (Change Interview; Elliott, Slatick, & Urman, 2001). The interviews were analysed using grounded theory analysis. The results showed that both specific and common factors in therapy function in a co‐occurring mode, hence suggesting a synergy effect between common factors and specific techniques or therapist factors in psychotherapy. The core category ‘experience of therapeutic change, within the secure frame of therapy, is a process of deconstructing and reconstructing the house you live in: Yourself’ emerged based on self‐exploration and self‐discovery and is then discussed in a theoretical constructivist framework. Implications for research on the issue of the process of therapeutic change are discussed.
Brassica rapa Polysaccharides Ameliorate CCl4‐Induced Acute Liver Injury in Mice through Inhibiting Inflammatory Apoptotic Response and Oxidative Stress
Authors: Li Qiuyue , Yang Hailing , Wang Wenxiang , Li Ning , Zou Xuemei , Li Yangxin , Fan Gang , Zhang Yi , Kuang Tingting 
Published: November 2019

AbstractBrassica rapa L., also called NIUMA, is used empirically in Tibetan medicine for its antioxidant, anti‐inflammatory and antiradiation activities. This study explored the hepatoprotective effects of B. rapa polysaccharides (BRPs) on acute liver injury induced by carbon tetrachloride (CCl4) in mice and the underlying mechanisms. Mice were treated with CCl4 after the oral administration of BRPs (55, 110 and 220 mg/kg) or bifendate (100 mg/kg) for 7 days. Blood and liver samples of mice were collected for analysis after 24 h. The ALP, ALT and AST levels and the biological activities of SOD, MDA and GSH−Px were measured. Histopathological changes in the liver were determined through hematoxylin and eosin staining. Moreover, TNF‐α, IL‐1β and IL‐6 expression levels were detected by commercial reagent kits. Finally, Western blot analysis was used to check the relative expression levels of caspase‐3, p‐JAK2 and p‐STAT3. The BRP pre‐treatment significantly decreased the enzymatic activities of ALT, ALP and AST in the serum, markedly increased the activities of SOD and GSH−Px in the liver and reduced the MDA concentration in the liver. BRPs alleviated hepatocyte injury and markedly inhibited the expression of TNF‐α, IL‐1β and IL‐6, also downregulating the CCl4‐induced hepatic tissue expression of caspase‐3. Furthermore, BRPs inhibited the JAK2/STAT3 signaling pathway in a dose‐dependent manner in the liver. This study demonstrated that BRPs exert hepatoprotective effect against the CCl4‐induced liver injury via modulating the apoptotic and inflammatory responses and downregulating the JAK2/STAT3 signaling pathway. Therefore, B. rapa could be considered a hepatoprotective medicine.
What resources do students need in a competency‐based online business communication program? A Westminster College case study
Authors: Seifert Christine , Newbold Curtis , Chapman Richard 
Published: November 2019

AbstractThe authors argue in this paper that self‐directed learning is a primary competency for hybrid and online business communication students in competency‐based programs. The results of a small case study of students in two professional, project‐based and competency‐based online graduate programs reveal an incongruent profile: While students tended toward high enthusiasm and aptitude for self‐directed learning, they chose learning resources that did not promote high levels of self‐direction. Student resistance to self‐direction suggests faculty in competency‐based programs must re‐think pedagogical approaches as well as the kinds of resources business and professional communication faculty provide for students and encourage them to use.
Chemical Reporters for Exploring Microbiology and Microbiota Mechanisms
Authors: Zhang Zhenrun J. , Wang Yen‐Chih , Yang Xinglin , Hang Howard C. 
Published: November 2019

AbstractThe advances made in bioorthogonal chemistry and the development of chemical reporters have afforded new strategies to explore the targets and functions of specific metabolites in biology. These metabolite chemical reporters have been applied to diverse classes of bacteria including Gram‐negative, Gram‐positive, mycobacteria, and more complex microbiota communities. Herein we summarize the development and application of metabolite chemical reporters to study fundamental pathways in bacteria as well as microbiota mechanisms in health and disease.
Percutaneous paraspinal access to the azygos vein to create a neo‐vena cava
Authors: Sorensen Matthew W. , Bauser‐Heaton Holly , Petit Christopher J. 
Published: November 2019

AbstractWe present the case of a child with congenital heart disease repaired in infancy with diffuse central venous occlusions resulting in central venous insufficiency, superior vena cava (SVC) syndrome, and intracranial bleeds. He presented to the catheterization laboratory for multiple transcatheter interventions to recanalize central venous channels which were unsuccessful by conventional methods. Therefore, extravascular venous channels were created to decompress his upper body by creation of a neo‐SVC and his lower body with a neo‐azygos vein to the neo‐SVC. The latter procedure required direct percutaneous access from a paraspinal approach in order to obtain continuity with the azygos vein. At latest follow‐up the patient is clinically well and asymptomatic.
Retracted: Adaptive control for a hypersonic vehicle based on evolutionary algorithm and convex optimization
Authors: Xu Xiaodong , Li Hongkai 
Published: November 2019

SummaryThe dynamic model of hypersonic vehicle is nonlinear in nature because of time conditions and probabilities of occurrences. The dynamic model differs from the real‐time model because of the uncertainties and degradation of performances. Moreover, an effective feedback system is used to transform the matched and unmatched possibilities and certainties. To solve these issues and develop an efficient model in hypersonic system, this proposed model utilizes an evolutionary algorithm, along with convex optimization. In this, the control system tracks the inputs and controls by using dynamic convex control system (DCCS). During the process of DCCS, the input matrix gain is adapted with the algorithm and adaptive elements with saturation factors that are handled with ultimate boundaries based on the results of the existing work. The tracking error and the utilization dead zone errors are rectified at the most using the proposed model. Finally, the numerical real‐time simulations are performed, and the effectiveness of the proposed model is demonstrated.
Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2H)‐ones as Potent Antitumor Agents
Authors: Bian Mengyao , Ma Lei , Wu Min , Wu Liexin , Gao Hui , Yi Wei , Zhang Chao , Zhou Zhi 
Published: November 2019

AbstractBy virtue of an efficient rhodium(III)‐catalyzed redox‐neutral C−H activation/ring‐opening of a strained ring/[4+2] annulation cascade of N‐methoxybenzamides with propargyl cycloalkanols, diverse 3‐acyl isoquinolin‐1(2H)‐ones were directly obtained in good yields and with excellent functional group compatibility. Additionally, their antitumor activities against various human cancer cells including HepG2, A549, MCF‐7 and SH‐SY5Y were evaluated and the action mechanism of the selected compound was also investigated in vitro. The results revealed that these products possessed a potent efficacy, by inhibiting proliferation and inducing apoptosis in a time‐dependent and dose‐dependent manner, suggesting that such compounds can serve as promising candidates for anti lung cancer drug discovery.