bluuebunny/crossref_metadata_2025_split huggingface dataset:
Will Climate Endowment Affect the Improvement of Agricultural Production Efficiency? Evidence From Cities in Zhejiang Province, China
Authors: Hu Yihang , Zhang Junbiao , Zeng Yangmei , Li Jie 
Published: December 2024

ABSTRACTClimate change poses constraints on nature‐based agricultural productivity, necessitating an understanding of urban agriculture's performance across varying climatic conditions. This study examines the impacts of temperature, precipitation, and evapotranspiration production potential on agricultural production efficiency using a pooled OLS model. The results show that there is a spatial pattern of alternating high and low agricultural production efficiency units, and in urban areas where agricultural production efficiency values hover around 0.5, there still exists significant potential for improvement. Through regression analysis, results show that the production potential of precipitation has a significantly positive impact on improving agricultural production efficiency. However, the effects of temperature production potential, evapotranspiration production potential, and insolation on agricultural production efficiency are either not significant or exhibit poor stability. The results of the heterogeneity test show that the effect of precipitation production potential on enhancing agricultural production efficiency varies between cities in northeastern and southwestern Zhejiang, with only a few cities experiencing significant benefits. Furthermore, the innovation of this study resides in its comprehensive application of management science, climatology, geography, and other interdisciplinary approaches to deeply explore the influences of different climatic resource endowments on agricultural production efficiency from a spatial perspective. This interdisciplinary research approach provides fresh insights into how urban agriculture can be optimized under complex and ever‐changing climatic conditions.
Tough and Stretchable Zwitterionic Eutectogels via Copolymerization‐Induced Phase Separation in a Targeted Deep Eutectic Solvent
Authors: Wang Rui , Gao Yifeng , Yu Kaixuan , Xu Ziqian , Ma Xiaofeng , Wu Linlin , Dou Qiang , Cui Sheng 
Published: December 2024

AbstractDeep eutectic solvent (DES)‐based eutectogels show significant promise for flexible sensors due to their high ionic conductivity, non‐volatility, biocompatibility, and cost‐effectiveness. However, achieving tough and stretchable eutectogels is challenging, as the highly polar DES tends to screen noncovalent bonds, such as hydrogen and ionic bonds, between polymer chains, limiting their mechanical strength. In this work, this issue is addressed by leveraging the limited solubility of zwitterionic polymers in a specific DES to induce phase separation, promoting dipole–dipole interactions between polymer chains. These interactions improve energy dissipation under mechanical stress, allowing the creation of tough and stretchable P(MAA‐co‐VIPS)/TBAC‐EG eutectogels through a copolymerization‐induced phase separation approach. Methacrylic acid (MAA) and sulfobetaine vinylimidazole (VIPS) are copolymerized within a tetrabutylammonium chloride‐ethylene glycol (TBAC‐EG) DES, resulting in a bicontinuous network. The bicontinuous structure consists of a PVIPS‐rich phase that enhances toughness via dipole–dipole interactions, and a PMAA solvent‐rich phase that enables high stretchability. The resulting eutectogel demonstrates excellent mechanical properties, including a strength of 1.76 MPa, toughness of 16.61 MJ m⁻3, and remarkable stretchability of 1293%, along with self‐recovery, self‐healing, and shape‐memory capabilities. The zwitterionic polymer‐specific DES design opens up broad application potential for these eutectogels in diverse fields.
Efficiency Criteria for Multicost Variational Models Driven by H‐Type I Functionals
Authors: Treanţă Savin , Bibic Anca‐Oana , Bibic Simona‐Mihaela 
Published: December 2024

ABSTRACTThis paper investigates a family of multicost variational models driven by H‐type I functionals. Concretely, under H‐type I assumptions of the involved functionals, we state and prove necessary and sufficient criteria of efficiency for a feasible point in the considered class of controlled variational models.MSC 2020 Classification: 49K20, 58E17, 58E25, 90C30
Clinical profiles in autism spectrum disorder: Enhancing diagnosis, treatment, and overall health outcomes
Authors: Machado Cruz Tielle 
Published: December 2024

AbstractBackgroundAutism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant challenges in communication, behavior, and social interaction. The prevalence of ASD is rising, with current estimates indicating that it affects 1 in 36 children in the United States. Traditional diagnostic methods often fail to capture the full complexity of ASD, leading to incomplete treatment approaches. This study aimed to enhance diagnostic and therapeutic approaches to ASD by identifying and categorizing 10 clinical profiles using precision medicine.MethodsThis study presents a new stratification model for ASD that classifies individuals based on prevalent comorbidities and underlying biological mechanisms. The model is based on a synthesis of existing literature, clinical observations, and expert insights. Data were collected from detailed clinical evaluations, patient histories, and laboratory tests, and the model was refined through iterative analysis. It integrates findings from genetic, neurological, and psychiatric research to develop a comprehensive approach for diagnosing and treating ASD‐related comorbidities.ResultsThe study proposes 10 clinical profiles of ASD: syndromic, gastrointestinal, metabolic, mitochondrial, endocrine, bioaccumulative, infectious, immunological, inflammatory, and Neurological. Each profile is associated with specific symptoms and comorbidities influenced by genetic, environmental, and biological factors.ConclusionsThe stratification model proposed in this study enhances the diagnosis and treatment of ASD by recognizing its heterogeneity. By identifying specific clinical profiles, healthcare providers can develop personalized and integrated therapeutic strategies to improve the overall health outcomes of individuals with ASD.
MiR‐766‐3p Inhibit the Proliferation, Stemness, and Cell Cycle of Pancreatic Cancer Cells Through the MAPK/ERK Signaling Pathway
Authors: Quan Zhipeng , Yin Ziwei , Huang Yuelin , Huang Xuemei , Huang Hao , Mo Qingrong , Gong Jianhua , Liu Lingyun , Zhou Yi , Yu Yaqun 
Published: December 2024

ABSTRACTBackgroundAs a commonly identified cancer in clinics, pancreatic cancer (PC) has poor prognostic outcomes. This work focused on clarifying the association between MIR‐766‐3P expression and PC development and progression, as well as the possible role as a biomarker in PC.MethodsMIR‐766‐3P expression within the human PC cells and samples was measured through miRNA RT‐PCR. The gene levels regulated by MIR‐766‐3P were analyzed through western blot (WB) and qRT‐PCR. To analyze whether MIR‐766‐3P was of certain significance in in vitro and in vivo PC cell proliferation, stemness, and cell cycle progression, the gain/loss‐of‐function assays were performed. Bioinformatics, RNA sequencing (RNA‐seq), and luciferase reporter assay were conducted for exploring regulatory role of MIR‐766‐3P/MAPK1/MAPK/ERK signal axis in PC.ResultIn comparison with the normal controls, MIR‐766‐3P expression markedly decreased the tissues and cells of PC. Furthermore, MIR‐766‐3P could remarkably inhibit the proliferation, stemness, cell cycle progression, and development of PC. The analyses using RNA‐seq, and dual‐luciferase examination showed that MIR‐766‐3P could directly target mitogen‐activated protein kinase 1 (MAPK1). According to Gene Ontology (GO) as well as Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, MIR‐766‐3P could affect PC malignant phenotype by MAPK1 and the regulation of the MAPK/ERK‐related pathway.ConclusionMIR‐766‐3P has a certain impact on PC malignant phenotype through combining with MAPK1 while regulating MAPK/ERK‐related pathway in vitro and in vivo.
Quality improvement for parenteral nutrition in hospital: Applying a gap analysis to an electronic health record to review parenteral nutrition processing
Authors: Kulyk Andrea , Dahmer Jolayne , Gramlich Leah 
Published: December 2024

AbstractBackgroundIn light of the complex and high‐risk nature of parenteral nutrition (PN), reviewing PN processing steps is essential to minimize patient harm. The main steps include ordering, verification, compounding, and administration. Electronic health records (EHRs) have become increasingly utilized and can play a critical role in enhancing the safety of PN processin. Epic EHR is used throughout all PN processing steps within our health system. There is limited literature on health system quality improvement initiatives in PN processing.MethodsWe reviewed the steps of PN processing in our health region and applied a gap analysis to assess Epic's functionality in PN processing. This gap analysis aimed to identify opportunities to enhance PN safety.ResultsEpic applies 32 of 40 functions that enhance PN safety. We selected three functions to prioritize adding into future EHR iterations; these include (1) bidirectional automatic interfacing between the automated compounding device and EHR reflecting real‐time updates on product availability/shortages, (2) automatically transmitting a pharmacist‐modified PN order back to the prescriber for approval, and (3) adding additional clinical decision support tools, one of which is incorporating a 3‐in‐1 qualification calculator and the second is requiring prescriber justification for using compounded formulations over multichamber bags. Additional opportunities for improving safety in PN processing were identified and added to the gap analysis.ConclusionUsing a gap analysis is a simple process to review a health system's EHR to identify opportunities to enhance patient care.
Reduced Order Modelling of Fully Coupled Electro‐Mechanical Systems Through Invariant Manifolds With Applications to Microstructures
Authors: Frangi Attilio , Colombo Alessio , Vizzaccaro Alessandra , Touzé Cyril 
Published: December 2024

ABSTRACTThis article presents the first application of the direct parametrisation method for invariant manifolds to a fully coupled multiphysics problem involving the nonlinear vibrations of deformable structures subjected to an electrostatic field. The formulation proposed is intended for model order reduction of electrostatically actuated resonating Micro‐Electro‐Mechanical Systems (MEMS). The continuous problem is first rewritten in a manner that can be directly handled by the parametrisation method, which relies upon automated asymptotic expansions. A new mixed fully Lagrangian formulation is thus proposed, which contains only explicit polynomial nonlinearities, which is then discretised in the framework of finite element procedures. Validation is performed on the classical parallel plate configuration, where different formulations using either the general framework or an approximation of the electrostatic field due to the geometric configuration selected are compared. Reduced‐order models along these formulations are also compared to full‐order simulations operated with a time integration approach. Numerical results show a remarkable performance both in terms of accuracy and the wealth of nonlinear effects that can be accounted for. In particular, the transition from hardening to softening behaviour of the primary resonance while increasing the constant voltage component of the electric actuation is recovered. Secondary resonances leading to superharmonic and parametric resonances are also investigated with the reduced‐order model.
Multivariate Optimization for the Production of OSA‐Starch Microcapsules Containing Clove and White Thyme Essential Oils: Antifungal Potential Against Penicillium digitatum
Authors: de Souza Estefania Júlia Dierings , dos Santos Felipe Nardo , Kringel Dianini Hüttner , de Souza Jaqueline Ferreira , Bueno Danielle Tapia , Leitzke Amanda Fonseca , Fajardo André Ricardo , Gandra Eliezer Avila , de Pereira Claudio Martin Pereira , Dias Alvaro Renato Guerra , Zavareze Elessandra da Rosa 
Published: December 2024

ABSTRACTThe objective of this study was to optimize the conditions for the production of microcapsules based on OSA‐starch and clove (CEO) and white thyme (WTEO) essential oils (EOs) obtained by electrospraying. The antifungal activity against the fungus Penicillium digitatum was assessed using both the well diffusion method and volatile release action. The microcapsules were characterized by morphology, loading capacity (LC) presence of functional groups (FTIR), and thermal properties (TGA). Spherical microcapsules were formed in all treatments evaluated, with an average diameter ranging from 0.803 to 1.500 μm. The morphology of the materials was not affected by the variation of the solution parameters (ethanol: 20% and 30%, OSA‐starch: 40% and 50%, CEO and WTEO, and EO concentration: 0.2% and 0.4%). The LC ranged from 30.6% to 97.9%, and TGA and FTIR analyses for all treatments confirmed the interaction of EOs with OSA‐starch. Microcapsules from OSA‐starch with CEO showed greater efficiency in reducing the mycelial growth of P. digitatum through the release of volatiles. These results serve as a basis for future studies to evaluate the technological applicability of these capsules in a food matrix or packaging material for controlling the fungal growth of P. digitatum.
A Two‐Center Study of a Prognostic Model Related to Acute Kidney Injury After Allogeneic Hematopoietic Stem Cell Transplantation in Children: Development of a New Predictive Dynamic Nomogram
Authors: Chen Zhiwei , Jia Wanyu , Guo Caili , Wu Yanwen , Liu Jian , Song Chunlan 
Published: December 2024

ABSTRACTObjectivesThe purpose of this study was to develop a straightforward, easy‐to‐use online dynamic nomogram for the identification of children who are at high risk of developing acute kidney injury (AKI) after allogeneic hematopoietic stem cell transplantation (allo‐HSCT).MethodsThis was a two‐center study in which 242 children in Henan Provincial Children's Hospital composed the training cohort, and 115 children in the First Affiliated Hospital of Zhengzhou University composed the validation cohort. Kaplan–Meier survival analysis was used to compare survival between children with nonacute kidney injury (NAKI) and children with AKI. Multivariate logistic regression analysis was used to identify risk factors for AKI in children who underwent HSCT. The selected variables were utilized to construct nomograms, which were validated via the concordance index (C‐index), decision curve analysis, calibration curve analysis, and receiver operating characteristic (ROC) curve analysis.ResultsCumulative survival was significantly lower in children with AKI than in children without kidney injury (p < 0.01). Eight variables were included in the nomogram: hepatic veno‐occlusive disease (HVOD), graft‐versus‐host disease (GVHD), ferritin, C‐reactive protein (CRP), Cytomegalovirus infection (CMV), thrombotic microangiopathy (TMA), human leukocyte antigen (HLA), and nephrotoxic drugs. The nomogram calibration curves in the training and validation cohorts were highly comparable to the standard curves. The areas under the curve (AUCs) of the prediction model were 0.963 and 0.910 in the training cohort and validation cohort, respectively. The decision curve analysis (DCA) revealed that the model had a significant clinical benefit.ConclusionsThe occurrence of AKI affects the prognosis of children who undergo HSCT. We developed a dynamic online nomogram for predicting AKI in children who underwent allo‐HSCT on the basis of eight variables. The predictive value and clinical benefit of the nomogram model were acceptable.
Screening and Impact of Neuropathic Pain in Young Individuals With Sickle Cell Disease
Authors: Adly Amira , Mohammed Maha , Aboata Ahmed , Wassif Ghada , Nassef Marwa , Makkeyah Sara 
Published: December 2024

AbstractObjectiveTo assess the frequency of neuropathic pain (NP) and its impact in young patients with sickle cell disease (SCD).MethodsWe used the ID‐Pain (ID‐P) questionnaire and a bedside clinical sensory testing (CST) as screening tools for NP and performed sensory nerve conduction study (SNCS) for all the participants. The impact of pain was assessed using Patient‐Reported Outcomes Measurement Information System (PROMIS) questionnaires and Pediatric Quality of Life Inventory (PedsQL) SCD module.ResultsThe mean age was 12.4 years. The ID‐P questionnaire revealed that 20.5% of patients likely had NP, while 10 (34%) of the participants had abnormal CST, and only two patients (4.5%) had abnormal SNCS. On the PROMIS pain scores, the mean pain intensity score was 7.9 ± 2.0. Pain interference was the most affected domain in both patients and parent proxy reports (mean ± SD T‐score 63.4 ± 6.6 and 65.2 ± 6.6, respectively) which was worse than other domains including pain quality—sensory and affective, and pain behavior (median T‐scores of 47.8, 63.0, and 56.2, respectively). The mean global health‐related quality of life (HRQoL) score of the children was 50.3 ± 12.1 indicating poor quality of life.ConclusionWe report the utility of simple tools like ID‐P questionnaire and CST for screening of NP in young individuals with SCD.
Unveiling the subconscious: How sexual dreams reflect and intensify mental problems
Authors: Egom Emmanuel Eroume A. , Mbah Teko Blaise , Ebango Suzanne Adolphine Soppi , Lema Bernadette Sandrine 
Published: December 2024

AbstractBackgroundSexual dreams represent a largely underexplored domain of human experience, particularly concerning their prevalence, frequency, and potential relationship with mental health conditions. Understanding this interplay may provide insights into the psychological and physiological effects of dream content.AimsTo investigate the prevalence, frequency, and impact of sexual dreams among individuals with and without mental health diagnoses and to evaluate the associations between sexual dream frequency, post‐dream symptoms, and mental health status.Materials & MethodsThe SLEEP Study surveyed 301 female‐identifying adults in the United States using an online questionnaire. The questionnaire assessed the frequency and content of sexual dreams, as well as post‐dream symptoms such as anxiety, increased heart rate, and muscle tension. Logistic regression and Pearson correlation analyses were conducted to examine relationships between sexual dream frequency, mental health diagnoses, and post‐dream symptoms.Results99.67% of participants reported experiencing sexual dreams, with 45.2% identifying them as frequent. A significant association was observed between frequent sexual dreams and mental health diagnoses (OR = 1.83, p = 0.018). While post‐dream symptoms such as anxiety and physical tension were common, their correlations with mental health treatment were weak and not statistically significant (p = 0.061).DiscussionThe findings suggest that frequent sexual dreams may serve as a psychological stress indicator, particularly in individuals with mental health conditions. However, the weak correlation between post‐dream symptoms and mental health treatment highlights the need for further investigation into the mechanisms underlying these associations.ConclusionFrequent sexual dreams could provide valuable insights into psychological stress and mental health. Incorporating dream patterns into mental health assessments may enhance clinical understanding and interventions. Further research involving diverse populations and experimental methodologies is required to these relationships and their broader implications.
Adaptive Phase‐Locked E‐Skin for Sports Physiology and Medicine
Authors: Zeng Qiankun , Shi Guoyue , Tang Jing , Zhang Min 
Published: December 2024

AbstractThe pursuit of creating materials that replicate the flexibility, stability, and advanced perceptual capabilities of human skin, attributes honed through natural evolution, represents a long‐term objective in pioneering fields such as electronic skin (e‐skin) research. However, conventional e‐skin often struggles with stability and functionality in harsh sports environments, resulting in the degradation of the intimate interface over time. Inspired by the innate biphasic structure of human subcutaneous tissue, an adaptive phase‐locked e‐skin (APLE) is presented, designed to seamlessly conform to dynamic sports environments, offering robust applications in sports physiology and medical contexts without malfunctioning. The APLE allows one to laminate onto the skin with consistent homeostasis, providing a foundation for advancing data‐driven sports physiology and creating personalized sports plans. Additionally, APLE offers immediate on‐site medical treatment for common sports injuries, including hemostasis and sutureless wound closure. Ultimately, the reported multifunctional e‐skin can provide significant value in managing sport‐related burdens through digital and people‐centered physiology monitoring, along with real‐time sport healthcare.
Optical Evidence of Interfacial Strain‐Induced Ferroelectric Tuning and Enhancement in CuInP2S6 via Ferroelectric Substrate
Authors: Hou Xinyi , Kong Fanyi , Tong Yunhao , Li Haoran , Dai Jianxun , Li Yongjiang , Huang Huolin , Sun Changsen , Gao Junfeng , Pan Lujun , Li Dawei 
Published: December 2024

AbstractThe precise domain control in ferroelectric CuInP2S6 (CIPS) remains challenging. A promising approach is by interfacing CIPS with the ferroelectric layer, but interface‐driven ferroelectricity tunning mechanism remains unclear. Here, the demonstration of interfacial strain‐induced ferroelectric tuning and enhancement in CIPS via ferroelectric substrate is reported by photoluminescence (PL) spectroscopy, combined with piezoresponse force microscopy (PFM) and density functional theory (DFT) calculations. PFM studies show that thin CIPS flakes form the same domain as that of ferroelectric PbZr0.52Ti0.48O3 (PZT) and P(VDF‐TrFE) films, suggesting enhanced polar alignment in CIPS via ferroelectric substrate. PL analyses show that a significant redshift occurs for PL emission of CIPS on ferroelectric substrate compared with that on conventional substrate, revealing interface tensile strain‐induced lattice change in CIPS, as further confirmed by DFT calculation. By analyzing PL spectra of monolayer MoS2 on CIPS/PZT, the polarization of CIPS is evidenced to be anti‐aligned with that of ferroelectric substrate. In situ, temperature‐dependent PL studies show that thin CIPS on ferroelectric substrate exhibits enhanced Curie temperature of higher than 200 °C. This study not only provides an effective material strategy to engineer the ferroelectric properties of CIPS but also offers a simple optical method to reveal interface‐driven ferroelectricity modulation mechanism in CIPS.