bluuebunny/crossref_metadata_2025_split huggingface dataset:
New treatments for canvas consolidation and conservation
Authors: Böhme Nadine , Anders Manfred , Reichelt Tobias , Schuhmann Katharina , Bridarolli Alexandra , Chevalier Aurelia 
Published: February 2020

Abstract
The aim of this study was to develop new, sustainable treatments for the consolidation and conservation of canvas of modern and contemporary art. Because of the diversity of painting types, two product groups which have polar and nonpolar character were developed. The treatment should be applicable to the back side of the canvas. The deacidification agents are sub-µm-particles of calcium carbonate or magnesium oxide which are dispersed in water or heptane. The polar components are hydroxyethyl methyl cellulose and nanocrystalline cellulose which are biopolymers derived from renewable raw materials. The nonpolar products were obtained by the silylation of the raw materials and allow the solubility in nonpolar solvents as heptane. Each product was applied to highly degraded, acidic model cotton canvas as well as canvas from real paintings. The application of these products showed a good increase of breaking force at a low increase of the mass of the canvas and also had only slight optical changes of the canvas. The deacidification of canvasses is a good preventive measure and can protect canvasses from future damage by acidity. The deacidification agents showed an increase of pH from acidic to alkaline after the treatment and a deposition of an alkaline reserve.
A conceptual framework for teaching computational thinking in personalized OERs
Authors: Moon Jewoong , Do Jaewoo , Lee Daeyeoul , Choi Gi Woong 
Published: February 2020

AbstractInterests towards teaching programming skills have risen recently in the realm of computing education. Learning how to program not only enables learners to develop computing applications, but it can also enhance learners’ computational thinking (CT) practice. CT refers to learners’ ability to approach ill-structured tasks systematically based on algorithmic thinking in computing. Along with growing academic interests towards CT in recent studies, researchers have emphasized the role of teaching programming in facilitating learners’ problem-solving skills. Emerging OERs have expanded learners’ opportunities to engage in hands-on programming exercises; yet a challenge still remains as to how learners’ programming exercises can be tailored to accommodate individual differences in terms of learners’ digital literacy skills. There is still a lack of in-depth discussions on how to support learners’ personalized learning experiences during programming exercises associated with CT. This study hence proposes a conceptual framework that seeks to consider how to promotelearners’ personalized learning experiences and enhance their CT skills in OERs. Through extensive reviewing of literature, this study provides several implications for further research.
“I was seen by a radiologist, but unfortunately I can’t remember the name and I still have questions. What should I do?” Radiologists should give thoughts to improve service professionalism and patient esteem
Authors: Gutzeit Andreas , Fischmann Arne , Forstner Rosemarie , Goette Romana , Herzog Bernhard , Kurtz Claudia , Hebler Chantal , Ladinger Andrea , Froehlich Johannes M , Blautzik Janusch , Kolokythas Orpheus , Matoori Simon , Kos Sebastian , Reischauer Carolin , Schefer Hubert , Dubsky Peter , Gampenrieder Simon Peter , Hergan Klaus , Gaissmaier Wolfgang , Koh Dow-Mu , Meissnitzer Matthias 
Published: February 2020

Abstract
Background
The aim of the study is to investigate how well patients remember the radiologist’s name after a radiological examination, and whether giving the patient a business card improves the patient’s perception of the radiologist’s professionalism and esteem.

Methods
In this prospective and randomized two-centre study, a total of 141 patients with BI-RADS 1 and 2 scores were included. After screening examination comprising mammography and ultrasound by a radiologist, 71 patients received a business card (group 1), while 70 received no business card (group 2). Following the examination, patients were questioned about their experiences.

Results
The patients in group 1 could remember the name of the radiologist in 85% of cases. The patients in group 2, in contrast, could only remember the name in 7% of cases (p < 0.001). 90% of the patients in group 1 believed it was very important that they are able to contact the radiologist at a later time, whereas only 76% of patients in group 2 felt that this was a very important service (p < 0.025). A total of 87% of the patients in group 1 indicated that they would contact the radiologist if they had any questions whereas 73% of the patients in group 2 would like to contact the radiologist but were not able to do so, because they could not remember the name (p < 0.001).
All questions were analysed with a Cochran-Mantel-Haenszel (CMH) test that took study centre as stratification into account. In some cases, two categories were collapsed to avoid zero cell counts.

Conclusions
Using business cards significantly increased the recall of the radiologist’s name and could be an important tool in improving the relationships between patients and radiologists and enhancing service professionalism.

Trial registration
We have a general approval from our ethics committee. The patients have given their consent to this study.
Improved genetic distance-based spatial deployment can effectively minimize inbreeding in seed orchard
Authors: Yang Boning , Sun Haihong , Qi Jiandong , Niu Shihui , El-Kassaby Yousry A. , Li Wei 
Published: February 2020

Abstract
Background
Inbreeding in seed orchards is expected to increase with the advancement of breeding cycles, which results in the delivery of crops with suboptimal genetic gain, reduced genetic diversity, and lower seed set. Here, a genetic distance-dependent method for clonal spatial deployment in seed orchards was developed and demonstrated, which reduced the inbreeding levels. The method’s main evaluation parameter of inbreeding is the genetic distance among individuals and the deployment method used an improved adaptive parallel genetic algorithm (IAPGA) based on Python language. Using inbreeding-prone Chinese Mongolian pine breeding population material originating from a single natural population, the proposed method was compared to a traditional orchard design and a distance-based design; namely, complete randomized block (RCB) and optimum neighborhood (ONA) designs, respectively.

Results
With the advancement of selective breeding cycles, group separation among orchard related individuals is expected to increase. Based on the genetic distance among individuals, the IAPGA design was superior in significantly reducing the inbreeding level as compared to the two existing designs, confirming its suitability to advanced-generation orchards where relatedness among parents is common. In the 1st, 2nd, and mixed generations clonal deployment schemes, the IAPGA design produced lower inbreeding with 87.22%, 81.49%, and 87.23% of RCB, and 92.78%, 91.30%, and 91.67% of ONA designs, respectively.

Conclusions
The IAPGA clonal deployment proposed in this study has the obvious advantage of controlling inbreeding, and it is expected to be used in clonal deployment in seed orchards on a large-scale. Further studies are needed to focus on the actual states of pollen dispersal and mating in seed orchards, and more assumptions should be taken into account for the optimized deployment method.
Successful management of an infant with hypertensive heart failure associated with Wilms’ tumor: a case report
Authors: Miura Hiroko , Kawana Shin , Sugino Shigekazu , Kikuchi Chika , Yamauchi Masanori 
Published: February 2020

Abstract
Background
Wilms’ tumor with hyperreninemia may result in critical cardiovascular decompensation. We report a case of severe hypertensive heart failure followed by tumor resection in a 3-month-old infant with Wilms’ tumor.

Case presentation
A 3-month-old girl was admitted to the intensive care unit for Wilms’ tumor with hypertension and hypoxia. Her systolic blood pressure was 110 mmHg, and her SpO2 was 92%. She presented with severe hypertensive heart failure and received mechanical ventilation and antihypertensive therapy for hypertension and heart failure. An alpha 2-adrenergic receptor agonist was used for sedation as part of her antihypertensive therapy. On hospital day 16, nephrectomy with tumor resection was performed under general anesthesia. Her systolic blood pressure did not vary more than 20 mmHg during surgery due to appropriate preoperative management. Hemodynamic collapse did not occur.

Conclusions
The highlight of this case report is the successful management of an infant with Wilms’ tumor, particularly with respect to preoperative hemodynamic control and sedation.
A clinical nomogram for the prediction of early mortality in elderly patients initiating dialysis for end-stage renal disease
Authors: Yoshida Masaki , Otsuka Masanori , Watanabe Yoshikazu , Harigai Takako , Sakurai Noriyuki , Kobatake Keiko , Yoshida Hiroaki , Kobayashi Satsuki , Matsumoto Takayuki , Sakamoto Tatsuhiko , Ueki Kazue 
Published: February 2020

Abstract
Background
The number of elderly patients (> 80 years of age) with end-stage renal disease is rapidly increasing. The initiation of dialysis extends the duration of survival; however, the rate of early mortality, that which occurs within the first few months after the initiation of dialysis, is reportedly higher than the rate of late mortality.

Methods
We retrospectively studied a cohort of 300 patients, aged 80 years or older, in whom dialysis was initiated between January 1, 2010, and December 31, 2017, at TOHO Hospital (Gunma, Japan). The rate of early mortality was assessed using the Kaplan-Meier method, and the equivalence of survival curves was tested using log-rank tests. The univariate and multivariate analyses were performed using the Cox proportional hazards model. To evaluate nomogram performance, we assessed both the discrimination and calibration of these models. Two hundred bootstrap resamples were used for internal validation of the accuracy estimates to reduce overfit bias and to determine 95% confidence intervals.

Results
The nomogram was built using the following nine predictors: serum albumin grams per deciliter (hazard ratio [HR] 0.63, p < 0.001), congestive heart failure (HR 1.81, p = 0.004), chronic obstructive pulmonary disease (HR 2.47, p = 0.014), peripheral vascular disease (HR 2.03, p = 0.019), hemiplegia (HR 2.06, p = 0.001), malignant tumors (no metastasis; HR 2.00, p < 0.001), metastatic malignant tumors (HR 4.67, p = 0.006), cardiovascular disease (HR 1.59, p = 0.002), bone fractures due to falls within 1 year (HR 1.85, p = 0.011), and Karnofsky Performance Status (HR 0.98, p < 0.001).

Conclusions
We developed and validated a nomogram that predicts early mortality in elderly patients at the initiation of dialysis for end-stage renal disease. The nomogram may help nephrologists make a shared decision with patients and families regarding the initiation of dialysis.
Detection of airway protective level of the cough reflex in acute stroke patients
Authors: Belal Ehab Shaker , Selim Samah , Aboul fotouh Alshaimaa M. , Mohammad Asmaa 
Published: February 2020

Abstract
Background
The most common respiratory complications in cerebrovascular strokes were respiratory infection, pulmonary edema, acute lung injury (ALI) acute respiratory distress syndrome (ARDS) and pulmonary embolism (PE). The inhalation cough challenge facilitates the quantification of cough.

Objectives
To detect the level of cough reflex that is enough to protect against respiratory infection in stroke patients, and to identify predictors of post-stroke respiratory infection.

Patients and methods
One hundred and one of cerebrovascular stroke patients were assessed in the first week of symptoms by National Institutes of Health Stroke Scale (NIHSS) Arabic version, Mann Assessment of Swallowing Ability (MASA), cough challenge test, cough flow meter, and A2DS2 score. Then, follow up after 1 week.

Results
Post-stroke respiratory infection was higher in older patients and those who were not working. Respiratory infection was significantly associated with high A2DS2 and NIHSS score (p value < 0.001). A highly significant increase in the levels of the inflammatory markers was detected in patients with a respiratory infection. Eighty percent of stroke patients with no cough developed a respiratory infection. The Mann total scores and the peak cough flow were lower in patients who had a respiratory infection.

Conclusion
Preserved cough reflex is essential in preventing aspirations and consequent respiratory infections.
Recurrent priapism in the setting of cannabis use
Authors: Montgomery Sebastian , Sirju Kristal , Bear Joseph , Ganti Latha , Shivdat John 
Published: February 2020

AbstractPriapism (persistent and painful erection of the penis) is a notable urological emergency, with over 90% of those remaining erect for 24 h losing sexual function. Drug-induced priapism is common in the adult population, with intracavernosal injectables for erectile dysfunction topping the list. A variety of illicit drugs associated with priapism have been described; however, we are not aware of any other case reports showing cannabis alone as the inciting factor. Here, we present a case of a healthy 32-year-old African American man with a history of stuttering (recurrent) priapism secondary to mild cannabis substance use without comorbid substance use, licit or illicit.
Value of ambroxol in the treatment of asthmatic bronchitis
Authors: Du Xiaoxia , Zhao Chengyan , Liu Shiqing , Su Shufen 
Published: February 2020

Objective: To investigate the clinical effect of ambroxol in the treatment of asthmatic bronchitis.
Methods: One hundred and twenty patients with asthmatic bronchitis who were admitted to our hospital from June 2017 to August 2018 were selected as the research subjects and divided into a control group and an observation group according to random number table method, 60 in each group. The control group was treated with conventional treatment, while the observation group was treated with ambroxol in addition to conventional treatment. The therapeutic effect, disappearance time of symptoms and signs and the recovery of pulmonary function were compared between the two groups.
Results: The total effective rate of the observation group was 96.7%, and that of the control group was 73.3%. The control effect of the observation group was significantly better than that of the control group, showing a significant difference (P<0.05). The disappearance time of symptoms of the observation group was shorter than that of the control group, and the recovery of pulmonary function was better; the differences were statistically significant (P<0.05).
Conclusion: For asthmatic bronchitis patients, addition of ambroxol to conventional treatment can improve the therapeutic effect, shorten the disappearance time of clinical signs and symptoms, and promote the recovery of patients, which is worth clinical application.
doi: https://doi.org/10.12669/pjms.36.3.1607
How to cite this:Du X, Zhao C, Liu S, Su S. Value of ambroxol in the treatment of asthmatic bronchitis. Pak J Med Sci. 2020;36(3):501-504. doi: https://doi.org/10.12669/pjms.36.3.1607
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Assessment of attitudes of patients with psychiatric disorders regarding electroconvulsive therapy as a treatment option
Authors: Khan Ghaazaan , Nazar Zahid , Ul-Haq Mian Mukhtiar , Hussain Mian Iftikhar 
Published: February 2020

Objective: To assess the attitudes of psychiatric patients towards electroconvulsive therapy (ECT) as a treatment modality.
Methods: This descriptive cross-sectional study was conducted from 1st January, 2017 to 15th April, 2018 in Department of Psychiatry, MTI, Lady Reading Hospital, Peshawar. It comprised of total 154 patients, having previous experience with electroconvulsive therapy (ECT) who were selected through a non-probability consecutive sampling. Their attitude was assessed by their responses to 15 questions on a Likert Scale, each question scoring 01-05 with a summed up cut-off score of 45 points. Score over 45 points is considered positive and below 45 as negative while those scoring exactly 45 points were considered as having Ambivalent attitude towards ECT.
Results: Of all, 73% patients revealed positive and 27% negative attitude towards ECT. Mean age of the sample was 35 years. Out of all patients, 67.5% were males & 32.5% females, 73% were married & 27% unmarried, 47% were illiterate & 53% variably educated, 43% were employed while 57% were unemployed.
Conclusion: A significant majority of the patients accepted ECT as an effective treatment modality. However, to make the procedure more acceptable, it may be made more effective and safe to the expectations of the patients and medical professionals for better outcomes.
doi: https://doi.org/10.12669/pjms.36.3.1637
How to cite this:Khan G, Nazar Z, Ul-Haq MM, Hussain MI. Assessment of attitudes of patients with psychiatric disorders regarding electroconvulsive therapy as a treatment option. Pak J Med Sci. 2020;36(3):565-568. doi: https://doi.org/10.12669/pjms.36.3.1637
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Role of surgical modality and timing of surgery as clinical outcome predictors following acute subdural hematoma evacuation
Authors: Altaf Imran , Shams Shahzad , Vohra Anjum Habib 
Published: February 2020

Background & Objective: A Craniotomy (CO) or decompressive craniectomy (DC) are the two main surgical procedures employed for evacuation of acute traumatic subdural hematoma (ASDH). However, the optimal surgical procedure remains controversial. The beneficial effect of early surgical evacuation of acute subdural hematoma in improving outcome also remains unclear. Our objective was to study the role of these two parameters in determining the outcome in patients undergoing surgical evacuation of acute traumatic subdural hematoma.
Methods: A retrospective analysis of 58 patients presenting with acute traumatic subdural hematoma and with presenting Glasgow Coma Scale (GCS) ≤ 8 that had been operated in Lahore General Hospital between June 2014 and July 2015 was performed. The demographic data, preoperative GCS, type of surgical procedure performed and timing of surgery were analysed.
Results: Forty (69%) patients underwent CO, and eighteen (31%) patients underwent DC. The CO and DC groups showed no difference in the demographic data and preoperative GCS. Six patients survived in the craniotomy group, while none survived in the decompressive craniectomy group (p=0.083). The relationship of timing of surgery with survival in the craniotomy group was found not to be clinically significant (p=0.87).
Conclusion: In this study craniotomy was associated with a better outcome as compared to decompressive craniectomy, however, the difference did not reach statistical significance. Early surgery was also found not to be associated with an improved outcome.
doi: https://doi.org/10.12669/pjms.36.3.1771
How to cite this:Altaf I, Shams S, Vohra AH. Role of surgical modality and timing of surgery as clinical outcome predictors following acute subdural hematoma evacuation. Pak J Med Sci. 2020;36(3):412-415. doi: https://doi.org/10.12669/pjms.36.3.1771
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The deep(er) roots of Eukaryotes and Akaryotes
Authors: Harish Ajith , Morrison David 
Published: February 2020

Background: Locating the root node of the “tree of life” (ToL) is one of the hardest problems in phylogenetics. The root-node or the universal common ancestor (UCA) divides descendants into organismal domains. Two notable variants of the two-domains ToL (2D-ToL) have gained support recently. One 2D-ToL posits that eukaryotes (organisms with nuclei) and akaryotes (organisms without nuclei) are sister clades that diverged from the UCA and that Asgard archaea are sister to other archaea, whereas the other proposes that eukaryotes emerged within archaea and places Asgard archaea sister to eukaryotes. Williams et al. (Nature Ecol. Evol. 4: 138–147; 2020) re-evaluated the data and methods that support the competing two-domains proposals and concluded that eukaryotes are the closest relatives of Asgard archaea. Critique: We argue that important aspects of estimating evolutionary relatedness and assessing phylogenetic signal in empirical data were overlooked. We focus on phylogenetic character reconstructions necessary to describe the UCA or its closest descendants in the absence of reliable fossils. It is well known that different character types present different perspectives on evolutionary history that relate to different phylogenetic depths. Which 2D-ToL is better supported depends on which kind of molecular features – protein-domains or their component amino acids – are better for resolving common ancestors at the roots of clades. In practice, this involves reconstructing character compositions of the ancestral nodes all the way back to the UCA. We believe the criticisms of 2D-ToL focus on superficial aspects of the data and reflects common misunderstandings of phylogenetic reconstructions using protein domains (folds). Clarifications: Models of protein domain evolution support more reliable phylogenetic reconstructions. In contrast, even the best available amino acid substitution models fail to resolve the archaeal radiation, despite employing thousands of genes. Therefore, the primary domains Eukaryotes and Akaryotes are better supported in a 2D-ToL.
Punishing the individual or the group for norm violation
Authors: El Zein Marwa , Seikus Chloe , De-Wit Lee , Bahrami Bahador 
Published: February 2020

Background: It has recently been proposed that a key motivation for joining groups is the protection from consequences of negative behaviours, such as norm violations. Here we empirically test this claim by investigating whether cooperative decisions and the punishment of associated fairness-based norm violations are different in individuals vs. collectives in economic games. Methods: In the ultimatum game, participants made or received offers that they could reject at a cost to their outcome, a form of social punishment. In the dictator game with third-party punishment, participants made offers to a receiver while being observed by a punisher, or could themselves punish unfair offers. Results: Participants made lower offers when making their decision as part of a group as compared to alone. This difference correlated with participants’ overall mean offers: those who were generally less generous were even less so in a group, suggesting that the collective structure was compatible with their intention. Participants were slower when punishing vs not punishing an unfair offer. Importantly here, they were slower when deciding whether to punish or not to punish groups as compared to individuals, only when the offer concerned them directly in second party punishment. Participants thus take more time to punish others, and to make their mind on whether to punish or not when facing a group of proposers. Conclusions: Together, these results show that people behave differently in a group, both in their willingness to share with others and in their punishment of norm violations. This could be explained by the fact that being in a collective structure allows to share responsibility with others, thereby protecting from negative consequences of norm violations.