bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Konsep Integrasi Ilmu Dalam Islam
Authors: Binti Khalid Ainor Syuhadah , Putri Intan Delsa 
Published: September 2020

Abstract: Article with the title ‘Analysis of the Concept of Integration of Science in Islam’, it discusses describing and analyzing concepts between sciences in Islam. Science we will describe later, is a system of meaning of reality and truth, based on revelation supported by reason and intuition. The method used in this study uses the method or literature study (library research). Literature study can be interpreted as an activity relating to the method of collecting library data, reading and recording and processing research materials. With nadzar and fikr processes, ratios will be able to articulate, make propositions, express opinions, argue, make analogies, make decisions, and draw conclusions. In the Islamic worldview, science is closely related to faith, ‘aql, qalb, and taqwa. Not only is knowledge systematically gathered, but knowledge is also an understanding. Where to calculate the haq Of course you will not argue with the haq. However, over time, hegemony and colonialism caused Muslims to replace and apply the concept of Western knowledge that is blindly. This attitude certainly causes confusion. So, trying to develop and develop the concept of science in the Qur'an can be made the basis for formulating the basis of knowledge in Islam.
Keywords: Integration of knowledge, worldview, and scientific methods.

Abstrak: Artikel dengan judul ‘Analisis Konsep Integrasi Ilmu dalam Islam’, ini bertujuan memaparkan dan menganalisis konsep intergrasi ilmu dalam Islam. Ilmu sebagaimana akan kita uraikan nanti, merupakan system pemaknaan akan realitas dan kebenaran, bersumber pada wahyu yang didukung oleh rasio dan intuisi. Metode yang digunakan dalam kajian ini menggunakan metode atau pendekatan kepustakaan (library research). Studi pustaka dapat diartikan sebagai serangkaian kegiatan yang berkenaan dengan metode pengumpulan data pustaka, membaca dan mencatat serta mengolah bahan penelitian. Dengan proses nadzar dan fikr, rasio akan dapat berartikulasi, menyusun proposisi, menyatakan pendapat, berargumentasi, membuat analogi, membuat keputusan, serta menarik kesimpulan. Dalam worldview Islam, ilmu berkaitan erat dengan iman, ‘aql, qalb, dan taqwa. Tidak hanya merupakan satu pengetahuan yang terhimpun secara sistematis, tetapi ilmu juga merupakan suatu metodologi. Dimana metodologi yang haq tentu tidak akan bertentangan dengan yang haq. Namun seiring berjalannya waktu, hegemoni dan kolonialisme menyebabkan umat Islam cenderung meniru dan mengadopsi konsep ilmu pengetahuan Barat secara membabi buta. Sikap ini tentu saja menyebabkan kebingungan (confusition) yang berlanjut pada hilangnya identitas. Maka, upaya menggali dan mengembangkan konsep ilmu dalam al-Qur‘an dapat dijadikan landasan bagi upaya merumuskan kerangka integrasi ilmu pengetahuan dalam Islam.
Kata kunci: Integrasi ilmu, worldview, metode keilmuan.
The Effectiveness of Problem-Based Learning in Improving Students’ Writing Descriptive Text in Vocational School
Authors: Amalia Rindi Dwi , Rusfandi Rusfandi 
Published: September 2020

One of the problems in teaching English to students in vocational high schools is how to make the students more active, creative, and critical. An alternative teaching method that can be used by teachers is Problem-Based Learning (PBL). The objective of this study is to investigate whether the use of PBL provides a significant effect on the students’ writing descriptive text. This study used a quasi-experimental design which was conducted at a vocational school in Malang. The participants of this study were class X Office Administration 1 as the experimental group consisting of 23 students and class X Office Administration 3 as the control group consisting of 23 students. The researcher gave pre-test and post-test and compared the participants’ writing scores in the control and experimental groups by using an independent sample t-test. The result of the post-test indicates that the students in the experimental group achieved a higher mean score than those in the control group on writing descriptive text. The statistical analysis reports that there was a significant difference in scores between the two groups (t = 6.99, p < 0.05). This finding indicates that PBL can be an effective method for teachers in teaching writing descriptive text.
Efek kepemilikan institusional, kinerja perusahaan, kualitas audit terhadap luas pengungkapan CSR perusahaan pertambangan
Authors: Setyawan Bagus , Apriyanto Gaguk , Firdiansjah Achmad 
Published: September 2020

Jenis dari penelitian ini adalah penelitian asosiatif kausal. Penelitian ini meneliti hubungan yang bersifat sebab akibat. Penelitian ini termasuk ke dalam penelitian kuantitatif karena mengacu pada perhitungan berupa angka. Sumber data penelitian ini adalah data sekunder yang diperoleh secara historis dari laporan tahunan, laporan keuangan, dan laporan keberlanjutan yang disajikan perusahaan pada tahun 2017-2018 yang telah go public dan terdaftar di Bursa Efek Indonesia. Dalam penelitian ini sampel yang diambil sesuai dengan kriteria yang digunakan dalam purposive sampling yang terdaftar selama tahun yang diteliti. Berdasarkan hasil yang didapatkan dengan menggunakan analisis kuantitatif, maka Hasil statistik deskriptif menunjukkan bahwa nilai rata-rata tata kepemilikan instistusional sebesar 55,92%. Hal ini menunjukkan bahwa kepemilikan instisuional sudah cukup efektif dalam memonitor aktivitas manajemen. Kinerja perusahaan yang diproksikan dengan ROA, memiliki rata-rata sebesar 5,91%. Hal ini menunjukkan bahwa perusahaan mampu menghasilkan keuntungan pada pada tahun 2017 dan 2018. Kualitas audit memiliki rata-rata sebesar 0,25, hal ini menunjukkan bahwa sebagian besar perusahaan diaudit bukan dari KAP Big 4. Pengungkapan (corporate social resposibility) CSR sebesar 71,35%, hal ini menunjukkan bahwa perusahaan mampu mengeluarkan biaya untuk kegiatan pembangunan ekonomi, sosial dan lingkungan.

Kata Kunci : Kepemilikan Institusional, Kinerja Perusahaan, Luas Pengungkapan CSR, Kualitas Audit
Application of Two-Channel Principle in Measuring Devices to Compensate for Disturbing Influences of Unknown Physical Nature
Authors: Nesterov V. N. , Li A. R. 
Published: September 2020

The article notes the advantages of the method of constructing absolutely invariant measuring transducers for working in conditions with disturbing influences. However, this method is not universal. Its limitations are due to the impossibility of "symmetric" transmission of all disturbing influences into parallel measuring channels. A broader interpretation of the two-channel principle is proposed to overcome these limitations. The aim of the study was to substantiate and implement a method for constructing quasi-invariant measuring transducers and systems that retain their metrological characteristics under external disturbances of unknown physical nature.The theory that develops the two-channel principle to a full-fledged technological method is presented in the article. The theory includes the necessary and sufficient conditions for physical feasibility this method. Two fundamental tasks have been solved in the work. The first task is to identify signs that reflect the essence of the technological method in to specific cases and the second is to implement a methodology that allows these signs to be effectively applied in practice.In the examples, a complex of technologies is defined for groups of elements of quasi-invariant transducers that provide compensation of the influencing factors acting on them with acceptable accuracy.There are significant advantages in discussed method. It gives hope for acceptable measurement results under conditions when character and even physical principle of influencing a priori are unknown.
Response of wheat DREB transcription factor to drought stress based on DNA methylation
Authors: Zhu Yanqiu , Wang Huihui , Jia Wenjing , Wei Xiaoyan , Duan Zhikun , Qi Qianting , Jiang Lina , Zhou Yanqing , Duan Hongying 
Published: September 2020

Abstract
Background: The growth and development of wheat are seriously influenced by drought stress, and the research on drought resistance mechanism of wheat is very important. Dehydration responsive element binding protein (DREB) plays an important role in the response of plant to drought stress, but epigenetic regulation for gene expression of DREB transcription factor is less studied, especially the regulatory role of DNA methylation has not been reported.Results: In this research, DREB2, DREB6 and Wdreb2 were cloned from wheat, their CDS sequences were composed of 732 bp, 837 bp or 1035 bp, respectively, and one 712 bp intron was found in DREB6. Although AP2/EREBP domain of DREB2, DREB6 and Wdreb2 had 73.25% identity, they belong to different types of DREB transcription factor, and the expression of Wdreb2 was significantly higher, yet was the lowest in DREB2. Under drought stress, the expression of DREB2, DREB6 and Wdreb2 could be induced, but had different trends along with the increase of stress time, and their expression had tissue specificity, was obviously higher in leaf. Promoter of DREB2, DREB6 and Wdreb2 in leaf was further studied, some elements related to adverse stress were found, and the promoter of DREB2 and Wdreb2 was slightly methylated, but DREB6 promoter was moderately methylated. Compared with the control, the level of promoter methylation in DREB2 and DREB6 decreased as stressed for 2 h, then increased along with the increase of stress time, which was opposite in Wdreb2 promoter, the status of promoter methylation in DREB2, DREB6 and Wdreb2 also had significant change under drought stress. Further analysis showed that promoter methylation of DREB6 and Wdreb2 was negatively correlated with their expression, especially was significant in Wdreb2. Conclusions: DREB2, DREB6 and Wdreb2 might function differently in response to drought stress, and promoter methylation had more significant effects on gene expression of Wdreb2 and DREB6.
Evaluation of duplicated reference genes for quantitative real-time PCR analysis in genome unknown hexaploid oat (Avena sativa&nbsp;L.)
Authors: Yang Zheng , Wang Kai , Aziz Usman , Zhao Cuizhu , Zhang Meng 
Published: September 2020

Abstract
Background: Oat (Avena sativa L.), a hexaploid crop with unknown genome, has valuable nutritional, medicinal and pharmaceutical uses. However, no suitable RGs (reference genes) for qPCR (quantitative real-time PCR) has been documented for oat yet. Single-copy gene is often selected as RG, which is challengeable or impactable in unexplored polyploids.Results: In this study, eleven candidate RGs, including four duplicated genes, were selected from oat transcriptome. The stability and the optimal combination of these candidate RGs were assessed in 18 oat samples by using four statistical algorithms including the ΔCt method, geNorm, NormFinder and BestKeeper. The most stable RGs for “all samples”, “shoots and roots of seedlings”, “developing seeds” and “developing endosperms” were EIF4A (Eukaryotic initiation factor 4A-3), UBC21 (Ubiquitin-Conjugating Enzyme 21), EP (Expressed protein) and EIF4A respectively. Among these RGs, UBC21 was a four-copy duplicated gene. The reliability was validated by the expression patterns of four various genes normalized to the most and the least stable RGs in different sample sets.Conclusions: Results provide a proof of concept that the duplicated RG is feasible for qPCR in polyploids. To our knowledge, this study is the first systematic research on the optimal RGs for accurate qPCR normalization of gene expression in different organs and tissues of oat.
Disparities In Cervical Cancer Screening Participation In Iran: A Cross-sectional Analysis of the 2016 Nationwide STEPS Survey
Authors: Amin Rozhin , Kolahi Ali-Asghar , Jahanmehr Nader , Abadi Ali-Reza , Sohrabi Mohammad-Reza 
Published: September 2020

Abstract
Background: One of the most important concerns in every healthcare system is the elimination of disparities in health service utilization and achievement of health equity. This study aims to investigate the disparities in cervical cancer screening participation in Iran.Methods: A cross-sectional study was conducted using data from the National Non-Communicable Risk Factors Survey in 2016 (STEPs 2016). Data on cervical cancer screening in addition to demographic and socio-economic factors from 15975 women aged 18 and above were analyzed. The distribution of surveyed women with regard to cervical cancer screening practice was described. Chi Square and logistic regression were used to assess the association of demographic and socio-economic factors with cervical cancer screening participation. Results: Overall, 52.1% of women aged 30-59 years, had undergone cervical cancer screening at least once in their lifetime. Participation rate in cervical cancer screening programs varied between provinces; ranging from 7.6% in Sistan and Baluchestan to 61.2% in Isfahan. Single marital status, illiteracy, being employed, and having no insurance coverage were associated with lower participation. Age and area of residence were insignificant predictors for participating in cervical cancer screening program. Analysis of the cervical cancer uptake rates across the socio-economic levels revealed that the service is less utilised by high income groups. Conclusions: Equity and participation in cervical cancer screening in Iran requires improvement. For this to be achieved, new policies shall have a stronger emphasis on the lowest and the highest socio-economic population groups, while current strategies have mostly affected the people with middle socio-economic status.
Peptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage
Authors: Hou Xuewen , Yuan Zijun , Wang Xuan , Cheng Rui , Zhou Xiaoguang , Qiu Jie 
Published: September 2020

Abstract
Hypoxic-ischemic brain injury (HIBD) causes neonatal death and serious neurological disability; however, there are currently no promising therapies for it excepting cooling. Therefore, in this study, we used peptidome analysis to identify differentially expressed peptides in cerebrospinal fluid (CSF) of neonates with HIBD or controls, which may give a foundation for finding new promising drugs of neonatal HIBD. CSF samples were collected from neonates with HIBD (n=4) or controls (n=4). ITRAQ LC-MS/MS was used to identify differentially expressed peptides between two groups. A total of 35 differentially expressed peptides from 25 precursor proteins were identified. The 2671.5Da peptide (HSQFIGYPITLFVEKER), one of the down-regulated peptides in neonatal HIBD, is a fragment of heat shock protein 90-alpha (HSP90α/HSP90AA1). Results of bioinformatics analysis showed that HSP90α/HSP90AA1 was located in the protein-protein interaction (PPI) network hub and was involved in the NOD-LIKE receptor (NLR) signaling pathway. This peptide, we named it HIBDAP (Hypoxic-Ischemic Brain Damage Associated Peptide), is a hydrophilic peptide with high stability and has a long half-life of 3.5h in mammalian reticulocytes. It was demonstrated that TAT-HIBDAP could successfully enter PC12 cells and further into the nucleus. After HIBDAP pretreatment and 6 hours of OGD treatment, low concentrations of HIBDAP increased the survival rate of cells, except 40μM had a toxic effect. Safe concentrations of HIBDAP reduced pyroptosis of PC12 cells under OGD, except 20μM had no effect, by suppressing expressions of NLRP3, ASC and Caspase-1 except NLRP1. The results of our study identified the characterization and expression profiles of peptides in CSF of neonatal HIBD. Several meaningful peptides such as HIBDAP may play significant roles in neonatal HIBD and provide new therapeutic targets for neonatal HIBD.
Complete genome analysis of a virulent Vibrio scophthalmi strain VSc190401 isolated from diseased marine fish half-smooth tongue sole, Cynoglossus semilaevis
Authors: zhang zheng , Yu Yong-xiang , Wang Yin-geng , Liu Xiao , Wang Lifang , Zhang Hao , Liao Mei-jie , Li Bin 
Published: September 2020

Abstract
Background: Vibrio scophthalmi is an opportunistic bacterial pathogen, which is widely distributed in the marine environment. Earlier studies have suggested that it is a normal microorganism in the turbot gut. However, recent studies have confirmed that this bacterial strain can cause diseases in many different marine animals. Therefore, it is necessary to investigate its whole genome for better understanding its physiological and pathogenic mechanisms.Results: In the present study, we obtained a pathogenic strain of V. scophthalmi from diseased half-smooth tongue sole (Cynoglossus semilaevis) and sequenced its whole genome. Its genome contained two circular chromosomes and two plasmids with a total size of 3,541,838 bp, which harbored 3,185 coding genes. Among these genes, 2,648, 2,298, and 1,915 genes could be found through annotation information in COG, Blast2GO, and KEGG databases, respectively. Moreover, 10 genomic islands were predicted to exist in the chromosome I through IslandViewer online system. Comparison analysis in VFDB and PHI databases showed that this strain had 334 potential virulence-related genes and 518 pathogen-host interaction-related genes. Although it contained genes related to four secretion systems of T1SS, T2SS, T4SS, and T6SS, there was only one complete T2SS secretion system. Based on CARD database blast results, 180 drug resistance genes belonging to 27 antibiotic resistance categories were found in the whole genome of such strain. However, there were many differences between the phenotype and genotype of drug resistance. Conclusions: Based on the whole genome analysis, the pathogenic V. scophthalmi strain contained many types of genes related to pathogenicity and drug resistance. Moreover, it showed inconsistency between phenotype and genotype on drug resistance. These results suggested that the physiological mechanism seemed to be complex.
Uncovering&nbsp;fungal community composition in natural habitat of Ophiocordyceps sinensis&nbsp;using high-throughput sequencing and culture-dependent&nbsp;approaches
Authors: Zhang Chuanbo , Ren Chao-Hui , Wang Yan-Li , Wang Qi-Qi , Wang Yun-Sheng , Weng Qing-Bei 
Published: September 2020

Abstract
Background: The fungal communities inhabiting natural Ophiocordyceps sinensis play critical ecological roles in alpine meadow ecosystem, contribute to infect host insect, influence the occurrence of O. sinensis, and are repertoire of potential novel metabolites discovery. However, a comprehensive understanding of fungal communities of O. sinensis remain elusive. Therefore, the present study aimed to unravel fungal communities of natural O. sinensis using combination of high-throughput sequencing and culture-dependent approaches. Results: A total of 280,519 high-quality sequences, belonging to 5 fungal phyla, 15 classes, 41 orders, 79 families, 112 genera, and 352 putative operational taxonomic units (OTUs) were obtained from natural O. sinensis using high-throughput sequencing. Among of which, 43 genera were identified in external mycelial cortices, Ophiocordyceps, Sebacinia, Archaeorhizomyces were predominant genera with the abundance of 95.86%, 1.14%, 0.85%, respectively. A total of 66 genera were identified from soil microhabitat, Inocybe, Archaeorhizomyces, unclassified Thelephoraceae, Tomentella, Thelephora, Sebacina, unclassified Ascomycota, unclassified Fungi were predominant genera with an average abundance of 53.32%, 8.69%, 8.12%, 8.12%, 7.21%, 4.6%, 3.08% and 3.05%, respectively. The fungal communities in external mycelial cortices were significantly distinct from the soil microhabitat. Meanwhile, seven types of culture media were used to isolate culturable fungi at 16°C, resulted in 77 fungal strains isolated by rDNA ITS sequence analysis, belonging to 33 genera, including Ophiocordyceps, Trichoderma, Cytospora, Truncatella, Dactylonectria, Isaria, Cephalosporium, Fusarium, Cosmospora and Paecilomyces, etc.. Among all culturable fungi, Mortierella and Trichoderma were predominant genera. Conclusions: The significantly differences and overlap in fungal community structure between two approaches highlight that the integration of high-throughput sequencing and culture-dependent approaches would generate more information. Our result reveal a comprehensive understanding of fungal community structure of natural O. sinensis, provide new insight into O. sinensis associated fungi, and support that microbiota of natural O. sinensis is an untapped source for novel bioactive metabolites discovery.
SAGA-CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity
Authors: Nuno-Cabanes Carme , Garcia-Molinero Varinia , Martín-Expósito Manuel , Gas Maria-Eugenia , Oliete-Calvo Paula , Garcia-Oliver Encar , Iglesia-Vaya María De la , Rodriguez-Navarro Susana 
Published: September 2020

Abstract
Background: Histone H2B deubiquitination is performed by numerous deubiquitinases in eukaryotic cells including Ubp8, the catalytic subunit of the tetrameric deubiquitination module (DUBm: Ubp8; Sus1; Sgf11; Sgf73) of the Spt-Ada-Gcn5 acetyltransferase (SAGA). Ubp8 is linked to the rest of SAGA through Sgf73 and is activated by the adaptors Sus1 and Sgf11. It is unknown if DUBm/Ubp8 might also work in a SAGA-independent manner. Results: Here we report that a tetrameric DUBm is assembled independently of the SAGA-CORE components SPT7, ADA1 and SPT20. In the absence of SPT7, i.e. independent of the SAGA complex, Ubp8 and Sus1 are poorly recruited to SAGA-dependent genes and to chromatin. Notably, cells lacking Spt7 or Ada1, but not Spt20, show lower levels of nuclear Ubp8 than wild type cells, suggesting a possible role for SAGA-CORE subunits in Ubp8 localization. Last, deletion of SPT7 leads to defects in Ubp8 deubiquitinase activity in in vivo and in vitroassays. Conclusions: Collectively, our studies show that the DUBm tetrameric structure can form without a complete intact SAGA-CORE complex and that it includes full length Sgf73. However, subunits of this SAGA-CORE influence DUBm association with chromatin, its localization and its activity.