bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life in burning mouth syndrome – a case-control study
Authors: Jedel Elizabeth , Elfström Magnus L. , Hägglin Catharina 
Published: August 2020

Abstract

Objectives
The cardinal symptom of burning mouth syndrome (BMS) is long-lasting pain and comprehensive health-related quality of life (HRQL) assessments may estimate how well patients with BMS live in relation to their health issues. The aims of the study were to explore general and BMS-specific HRQL based on an HRQL model and to compare HRQL in patients with BMS and age-matched controls.

Methods
For this case-control study 56 female patients with BMS and 56 female controls completed the following: A general questionnaire with Global items for life satisfaction, general health and oral health; General Population-Clinical Outcomes in Routine Evaluation (GP-CORE); Hospital Anxiety and Depression Scale (HADS); and Oral Health Impact Profile-14 (OHIP-14). Patients with BMS completed additional questionnaires which included BMS-problem severity, a global item for ratings of overall severity perceptions measured by visual analog scale (VAS); and BMS-modified Multidimensional Pain Inventory-Swedish version (MPI-S). BMS-modified MPI-S includes the three subscales Pain severity, Interference and Social support.

Results
Patients with BMS scored worse on all global items, GP-CORE, HADS and OHIP-14 compared to controls and the differences were large. Patients with severe BMS problems, as defined by a median split on BMS-problem severity, scored worse on the BMS-modified MPI-S subscale Pain severity and the difference was large.

Conclusions
We found clearly impaired general HRQL in patients with BMS compared to controls. For specific HRQL, the severity of pain was worse among patients with higher overall BMS-problem severity. The HRQL model with global ratings together with physical, psychological and social concepts has capacity to increase comparability and validity of studies, however further evaluations of the measures are needed.
The HRQL model may be used over time to increase the understanding of different HRQL aspects and their internal relationships. In clinical settings, with an increased knowledge of one´s own distinctive quality of life abilities and restrictions, the patients with BMS can be guided and supported to manage their long-lasting pain. The HRQL model may be an aid toward bridging distinctions between general and oral health to further encourage collaboration between medicine and odontology.
Editorial
Authors: Nunes João Fernando Igansi 
Published: August 2020

A Extensão é a ação de interação entre universidade e sociedade, existe e opera na Cultura dos grupos da qual participa e decorre. Amalgamadas, extensão e cultura desenvolvem-se, transformam-se e ganham novos sentidos. Pela heterogeneidade dos seus atores, com impacto direto na qualificação cidadã, crítica, saudável e criativa, a Cultura atende a missão da universidade: conhecimento aplicado, em amplitude do saber fazer, na transversalidade das suas dimensões acadêmicas integralizadas. Considerando a universidade como parte inseparável da sociedade, e vice-versa, torna-se difícil, ou provavelmente impossível, desenvolver a tríade Ensino, Pesquisa e Extensão sem pautar a Cultura como um elemento constitutivo, integrado e fundamental para a formação do sujeito. Estas dimensões, que são complementares, estão para além das disciplinas. Cada uma delas é um sistema em expansão articulado e comprometido com o contexto no qual agem, no qual funcionam, como verdadeira metáfora da chave com o cadeado. O compartilhamento entre "mundos" permite a criação de outros "mundos" e, consequentemente, compreensões de suas realidades em estado contínuo de transformação. Como uma criança que aprende a perspectiva e passa a perceber o espaço pelo seu escalonamento, desde cedo, também escalona o tempo por entre sua prática e modifica seus processos, velocidades e sonhos. A experiência, assim, produz significado pela cultura e possibilita construir formas de ser, de expressar, de pensar e de decidir, à vista disso, por um ou outro caminho. Nela se potencializa a permanência dos valores humanos e/ou os seus esvaecimentos, ambos pautados pela pluralidade dos perfis dos seus inter-atores (professores, técnicos, alunos, comunidade externa) e de suas emergências: viver e ser feliz com a sua vida e a vida do outro.
Microglial mTOR is Neuronal Protective and Antiepileptogenic in the Pilocarpine Model of Temporal Lobe Epilepsy
Authors: Zhao Xiao-Feng , Liao Yuan , Alam Mahabub Maraj , Mathur Ramkumar , Feustel Paul , Mazurkiewicz Joseph E. , Adamo Matthew A. , Zhu Xinjun C. , Huang Yunfei 
Published: August 2020

Excessive activation of mammalian target of rapamycin (mTOR) signaling is epileptogenic in genetic epilepsy. However, the exact role of microglial mTOR in acquired epilepsy remains to be clarified. In the present study, we found that mTOR is strongly activated in microglia following excitatory injury elicited by status epilepticus. To determine the role of microglial mTOR signaling in excitatory injury and epileptogenesis, we generated mice with restrictive deletion of mTOR in microglia. Both male and female mice were used in the present study. We found that mTOR-deficient microglia lost their typical proliferative and inflammatory responses to excitatory injury, whereas the proliferation of astrocytes was preserved. In addition, mTOR-deficient microglia did not effectively engulf injured/dying neurons. More importantly, microglial mTOR-deficient mice displayed increased neuronal loss and developed more severe spontaneous seizures. These findings suggest that microglial mTOR plays a protective role in mitigating neuronal loss and attenuating epileptogenesis in the excitatory injury model of epilepsy.SIGNIFICANCE STATEMENTThe mammalian target of rapamycin (mTOR) pathway is strongly implicated in epilepsy. However, the effect of mTOR inhibitors in preclinical models of acquired epilepsy is inconsistent. The broad presence of mTOR signaling in various brain cells could prevent mTOR inhibitors from achieving a net therapeutic effect. This conundrum has spurred further investigation of the cell type-specific effects of mTOR signaling in the CNS. We found that activation of microglial mTOR is antiepileptogenic. Thus, microglial mTOR activation represents a novel antiepileptogenic route that appears to parallel the proepileptogenic route of neuronal mTOR activation. This may explain why the net effect of mTOR inhibitors is paradoxical in the acquired models of epilepsy. Our findings could better guide the use of mTOR inhibitors in preventing acquired epilepsy.
Stress Impairs Intentional Memory Control through Altered Theta Oscillations in Lateral Parietal Cortex
Authors: Quaedflieg C.W.E.M. , Schneider T.R. , Daume J. , Engel A.K. , Schwabe L. 
Published: August 2020

Accumulating evidence suggests that forgetting is not necessarily a passive process but that we can, to some extent, actively control what we remember and what we forget. Although this intentional control of memory has potentially far-reaching implications, the factors that influence our capacity to intentionally control our memory are largely unknown. Here, we tested whether acute stress may disrupt the intentional control of memory and, if so, through which neural mechanism. We exposed healthy men and women to a stress (n= 27) or control (n= 26) procedure before they aimed repeatedly to retrieve some previously learned cue-target pairs and to actively suppress others. While control participants showed reduced memory for suppressed compared with baseline pairs in a subsequent memory test, this suppression-induced forgetting was completely abolished after stress. Using magnetoencephalography (MEG), we show that the reduced ability to suppress memories after stress is associated with altered theta activity in the inferior temporal cortex when the control process (retrieval or suppression) is triggered and in the lateral parietal cortex when control is exerted, with the latter being directly correlated with the stress hormone cortisol. Moreover, the suppression-induced forgetting was linked to altered connectivity between the hippocampus and right dorsolateral prefrontal cortex (PFC), which in turn was negatively correlated to stress-induced cortisol increases. These findings provide novel insights into conditions under which our capacity to actively control our memory breaks down and may have considerable implications for stress-related psychopathologies, such as posttraumatic stress disorder (PTSD), that are characterized by unwanted memories of distressing events.SIGNIFICANCE STATEMENTIt is typically assumed that forgetting is a passive process that can hardly be controlled. There is, however, evidence that we may actively control, to some extent, what we remember and what we forget. This intentional memory control has considerable implications for mental disorders in which patients suffer from unwanted (e.g., traumatic) memories. Here, we demonstrate that the capacity to intentionally control our memory breaks down after stress. Using magnetoencephalography (MEG), we show that this stress-induced memory control deficit is linked to altered activity in the lateral parietal cortex and the connectivity between the hippocampus and right prefrontal cortex (PFC). These findings provide novel insights into conditions under which memory control fails and are highly relevant in the context of stress-related psychopathologies.
PERANCANGAN ILUSTRASI BUKU CERITA RAKYAT ASAL MULA TERBENTUKNYA DAERAH GUNUNGPATI KOTA SEMARANG SEBAGAI MEDIA PENYAMPAI PESAN MORAL BAGI GENERASI MUDA
Authors: Majid Maghfur Imam Abdul , Syakir Syakir , Mujiyono Mujiyono 
Published: August 2020

Kota Semarang memiliki warisan budaya kekayaan sastra. Salah satunya adalah cerita rakyat yang menceritakan asal usul daerah Gunungpati. Namun masih banyak orang yang tidak mengenal adanya cerita rakyat tersebut. Padahal di dalam sejarah cerita rakyat Gunungpati memiliki potensi dan kandungan nilai budaya yang tinggi. Jika hal ini dibiarkan begitu saja maka lama-kelamaan punah. Perlu adanya suatu media yang dapat memperkenalkan, mengabadikan dan menyampaikan pesan-pesan yang terkandung dalam cerita rakyat Gunungpati melalui visualisasi yang lebih menarik, modern dan imajinatif. Penulis merepresentasikan cerita rakyat ke dalam pembuatan sebuah ilustrasi buku. Proses pembuatan ilustrasi buku menggunakan perpaduan teknik manual dan digital. Bahan yang digunakan penulis dalam proses pembuatan karya ilustrasi berupa kertas jenis aquarel 200 gsm dengan pendekatan secara realistis. Visualisasi berupa penerjemahan narasi dan teks menjadi ilustrasi yang banyak menggambarkan beberapa figur, hewan, tokoh dan atribut Jawa dengan setting tempo dahulu dengan cat air secara transparan dan plakat. Penulis telah menghasilkan 13 karya ilustrasi berukuran A2. Serta hasil akhir berupa dummy buku ilustrasi Cerita Rakyat dengan jumlah 30 halaman. Melalui perancangan ini diharapkan dapat menjadi media penyampai pesan moral yang terkandung dalam cerita rakyat Gunungpati serta menjadi sebuah sumber edukasi visual yang menarik, sehingga mampu menarik minat khususnya generasi muda untuk lebih peka dan menghargai serta melestarikan warisan budaya setempat dari para pendahulu.
Human Trafficking and Migrant Workers: Analysis of Indonesian Migrant Workers Protection in Overseas
Authors: Mahardika Angga Putra , Wicaksono Sonny Saptoajie 
Published: August 2020

The problems in this research are concerning to the regulations on the legal protection of illegal Indonesian migrant workers abroad who are victims of trafficking in persons already comprehensive, and the forms, mechanisms and procedures for legal protection of illegal Indonesian migrant workers abroad who are victims of trafficking in persons in BP3TKI Central Java already comprehensive?This thesis research uses a qualitative approach with a juridical-empirical method. The results of research and discussion show that based on Law Number 18 of 2017 concerning the Protection of Indonesian Migrant Workers Overseas (PMI Law), the protection provided to victims of human criminal acts includes legal, social and economic protection. Whereas Law Number 21 of 2007 concerning Eradication of the Criminal Act of Trafficking in Persons (Huma Trafficking Act) grants the right to victims of human trafficking, among others, restitution, rehabilitation and repatriation. The most important form of legal protection for Indonesian migrant workers who are victims of trafficking in persons by Central Java BP3TKI is the repatriation of victims. In addition, the BP3TKI also conducts law enforcement against the perpetrators who are suspected of committing criminal acts of people. In conducting protection efforts, the Central Java BP3TKI collaborates with various parties such as the local police, BNP2TKI, and representatives of the Indonesian state in the placement country.
PERMASALAHAN KRONOLOGIS PRASASTI PUPUS
Authors: Wibowo Aditya Krisna , Rahayu Andriyati 
Published: August 2020

<p>The Pupus inscription, which was made of metal, has suffered from a lot of corrosion, especially in the area where the date was inscribed, which has cast doubt on its actual chronology. When we are dealing with an ancient inscription, such lack of chronological clarity can cause historical uncertainty. The purpose of this study was to ascertain the chronology of the Pupus inscription. This study used the comparative method. The data in<br />this study consisted of the Pupus inscriptions as primary data and other inscriptions from two specific eras: i.e. the Kadiri period and Kayuwangi-Balitung period, as secondary or comparative data. The results show that the Pupus inscription was issued during the Dyah Balitung period, i.e. in 822 Śaka, but was copied in the 10th century A.D. or during the Kadiri era.</p>
A határon átnyúló tanulmányi célú ingázás mint az intergenerációs társadalmi mobilitás eszköze
Authors: Horváth Veronika 
Published: August 2020

A cikk a Nyugat-Dunántúlról Ausztriába irányuló tanulmányi célú ingázást vizsgálja. Első fele a diákok határon átívelő mobilitásának elterjedtségét és főbb jellemzőit mutatja be a 2011. évi Népszámlálás és a 2016. évi Mikrocenzus adatai alapján, majd – gyermeküket osztrák nevelési-oktatási intézménybe járató szülők körében készített interjúk eredményeire támaszkodva – a határátlépéssel járó tanulási célú ingázás okainak, céljainak, illetve előnyeinek és hátrányainak ismertetése következik.
A leíró statisztikai elemzés eredményei azt mutatják, hogy Magyarországról a munkavállalási céllal ingázók népes csoportja mellett jelentős számú eltartott gyermek is átjár Ausztriába tanulni. A diákok határátlépéssel járó ingázása az ország más részein is jelentős, ugyanakkor az Ausztriába irányuló oktatási célú mobilitás ezektől lényegesen eltérő jelenség: a szülőkkel készült interjúk rámutatnak arra, hogy az intergenerációs társadalmi mobilitás egyik lehetséges csatornájának tekinthető. A szülők – saját elhatározásukból – már egészen fiatal korban ausztriai óvodába, általános vagy középiskolába íratják gyermeküket, jellemzően a nyelvtanulás és a későbbi munkavállalás reményében. E döntés mögött a szülőknek az a törekvése áll, hogy gyermekeiknek az iskoláztatás révén minél jobb esélyeket kínáljanak az életben való boldogulásra, számukra kedvezőbb lehetőségeket rejtő jövőt biztosítsanak. Az ausztriai taníttatás tehát távlati döntésnek számít. Összességében azonban úgy látszik, hogy a határ közelében élő családoknak csak töredéke dönt az osztrák iskoláztatás mellett. Ez a döntés részben a család anyagi helyzetének és társadalmi kapcsolatainak, részben pedig az ingázással töltött idő, és a tömegközlekedéshez való hozzáférés függvénye. Akik viszont külföldön iskoláztatják gyermeküket, elkötelezettek az iskolai képzés Ausztriában történő befejezése, valamint gyermekük későbbi külföldi munkavállalása mellett.
Városkép és építészetszociológia : Gondolatok Elisabeth Lichtenberger munkásságáról
Authors: Tamáska Máté 
Published: August 2020

Tanulmányomban az osztrák városföldrajz 2017-ben elhunyt, nemzetközileg is elismert kiváló tudósának, Elisabeth Lichtenbergernek néhány építészetszociológiai szempontból releváns alaptézisét mutatom be. Elemzésemben mindenekelőtt arra keresem a választ, miben sajátos Lichtenberger térfelfogása, miért tekinthetjük őt az elmúlt két-három évtizedben német nyelvterületen formálódó építészetszociológiai gondolkodás egyik előfutárának. Ehhez empirikus városkutatásait mutatom be, azokat a gondolatokat, amelyek az építészet társadalminak nevezhető leírását és értelmezését adhatják, mint például a házformák tipológiája, a politikai-társadalmi rendszerek városideálja vagy a változásdinamika.
A tanulmány zárásaként öt pontban foglalom össze Lichtenberger munkásságának építészeti tanulságait, melyek: (1) az építészeti (házfelmérési) módszertan alkalmazható a társadalomtudományban; (2) az építészeti és a társadalmi tér együttjárása sajátos mintázatot mutat; (3) a retrospektív eljárás a művészettörténetileg kevésbé értékes, de szociológiailag annál relevánsabb építészeti emlékekre irányíthatja a figyelmet; (4) a városkép örökölt építészeti elemei erősen determinálják a településkép és a társadalom mindenkori alakulását; (5) az idő rétegei a városképekben igen változatos formában és a társadalmi értékrend által meghatározott módon jelennek meg.
results of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer. Comparative efficiency of hypofractionation and classical fractionation schedules
Authors: Abdujapparov A. S. , Tkachev S. I. , Aliev V. A. , Romanov D. S. , Madyarov J. M. , Glebovskaya V. V. 
Published: August 2020

Objective: comparison of the effectiveness of the results of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer using classical and hypofractionated schedule of radiation therapy.Materials and methods. This study is based on a retrospective analysis of a database of patients with locally advanced rectal cancer (T3C–D, positive circumferential resection margin or T4) who underwent a prolonged course of neoadjuvant chemoradiotherapy followed by surgery. The patients were divided into two groups: the first (main) group, 71 patients who received a course of chemoradiotherapy in hypofractionation schedule as part of neoadjuvant treatment (4 Gy × 40 Gy, 3 fractions per week) in combination with chemotherapy with capecitabine 1650 mg / m2 in two doses on weekdays. The second group (control group) included 79 patients who treated with long-course chemoradiotherapy in the classic fractionation mode (2 Gy × 50–58 Gy, 5 fractions per week) in combination with chemotherapy with capecitabine 1650 mg / m2 in two doses on weekdays. In the preoperative period, along with chemoradiotherapy, 4–8 courses of the systemic chemotherapy in the CapOx mode was used. The primary endpoint of this study was pathological complete response. Secondary endpoints included the seve rity of early radiation and hematological toxicity, the incidence of local recurrence, distant metastases, overall and disease-free survival. Results. The study included 150 patients. The overall frequency of acute radiation toxicity of grade III–IV was 5.6 % in the main group and 8.9 % in the control group (p = 0.658), from them hematological toxicity – 2.82 % and 7.6 %, respectively (p = 0.350), skin and pelvic organ toxicity – 2.82 % and 1.3 %, respectively (p = 0.926). Complete pathological response of III degree in the groups achieved 22.5 % and 19 %, respectively (p = 0.593), grade IV – 18.3 % and 15.2 %, respectively (p = 0.829). In the main and control groups, 4.2 % and 3.8 % of local recurrence were registered, respectively (p = 0.954; hazard ratio (HR) 1.05; 95 % confidence interval (CI) 0.21–5.22). The median time of disease-free survival was 39.4 months. The three-year disease-free survival in the main group was 73.2 % and in the control group 64.6 %, respectively (p = 0.353; HR 0.79; 95 % CI 0.42–1.35). The three-year overall survival in the main and control groups were 84.5 % and 82.3 %, respectively (p = 0.743; HR 0.87; 95 % CI 0.39–1.92). Conclusions. The hypofractionation schedule can be considered as an alternative and not inferior to the standard dose fractionation regimen in a prolonged course of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer.
Revised Badenian (middle Miocene) depositional systems of the Austrian Vienna Basin based on a new sequence stratigraphic framework
Authors: Siedl Wolfgang , Strauss Philipp , Sachsenhofer Reinhard F. , Harzhauser Mathias , Kuffner Thomas , Kranner Matthias 
Published: August 2020

Abstract
This paper presents a revised sequence stratigraphy for the lower, middle and upper Badenian depositional systems of the Austrian Vienna Basin based on the integration of 3D seismic surveys and well data. The study area in the central and northern part of the Austrian Vienna Basin is covered with 3D seismic data. According to a new sequence stratigraphic framework established in the southern part of the Vienna Basin, the Badenian is subdivided into three 3rd order depositional sequences. For each sequence, paleogeographic maps are created, representing coeval depositional systems within a chronostrati-graphic interval. Lower Badenian sediments of the 1st sequence (Ba1) represent fillings of the pre-Badenian sub-basins with a major change of sediment transport direction. The early stage of the 1st sequence is dominated by subaerial braided river deposits which use two pronounced canyon systems (Mistelbach Canyon and Reinthal Canyon) on the northwestern margin of the Vienna Basin as a bypass zone towards the marine depositional system of the North Alpine-Carpathian Foredeep. The late stage of the 1st sequence reflects the change from subaerial to marine depositional environments with main sediment influx from the west, creating two major eastwards prograding delta systems (Zistersdorf Delta and Mühlberg Delta). Depositional systems of the middle Badenian 2nd sequence (Ba2) reflect the interplay between ongoing extensional fault tectonics and major sea-level changes. Lower Badenian paleo-highs in the northern part are drowned during the 3rd sequence (Ba3), thus the Mühlberg Delta and the Zistersdorf Delta merge into one delta system. During the Ba3 the drowning of the Spannberg Ridge initiates a clockwise rotation of the Zistersdorf Delta. Thus, the former Zistersdorf Delta transforms into the Matzen Delta covering the Spannberg Ridge. Together with the Mühlberg Delta, they represent the last full marine depositional system of the eastward prograding paleo-Danube Delta in the Austrian Vienna Basin.
Bol E-Tümlenmiş Modüllere ve E-Yükseltilebilir Modüllere Torsiyon-Teorik Bir Yaklaşım
Authors: SÖZEN Esra 
Published: August 2020

Bu çalışmada bol τ_e-tümlenmiş ve τ_e-yükseltilebilir modülleri tanımlıyoruz ve bu yapıların temel özelliklerini araştırıyoruz. Ayrıca τ_e-tümlenmiş, bol τ_e-tümlenmiş ve τ_e-yükseltilebilir modüller arasındaki ikili ilişkileri belirtiyoruz. Bu çalışmada bol τ_e-tümlenmiş ve τ_e-yükseltilebilir modülleri tanımlıyoruz ve bu yapıların temel özelliklerini araştırıyoruz. Ayrıca τ_e-tümlenmiş, bol τ_e-tümlenmiş ve τ_e-yükseltilebilir modüller arasındaki ikili ilişkileri belirtiyoruz. Bu çalışmada bol τ_e-tümlenmiş ve τ_e-yükseltilebilir modülleri tanımlıyoruz ve bu yapıların temel özelliklerini araştırıyoruz. Ayrıca τ_e-tümlenmiş, bol τ_e-tümlenmiş ve τ_e-yükseltilebilir modüller arasındaki ikili ilişkileri belirtiyoruz.