bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die Hamburger Parkinson-Tagesklinik: Ein neues Behandlungskonzept an der Grenze zwischen stationärer und ambulanter Versorgung
Authors: Fründt Odette , Veliqi Ermir , Schönwald Beate , Sychla Polina , Gerloff Christian , Buhmann Carsten 
Published: April 2020

Zusammenfassung
Hintergrund Für Patienten mit komplexem Parkinson-Syndrom (PS), die einer durchgreifenden Umstellung von Medikation, Pumpeneinstellung oder Tiefer Hirnstimulation bedürfen, ist die ambulante Behandlung oft aufgrund limitierter zeitlicher und / oder fachlicher Ressourcen nicht ausreichend, die stationäre Versorgung bei fehlender Alltagsbelastung im Klinikalltag jedoch ebenfalls nicht adäquat. Das Modell der Hamburger Parkinson-Tagesklinik (PTK) wurde entwickelt und etabliert, um diese Versorgungslücke zu schließen.
Methode Hier beschreiben wir das neue und umfassende, individuelle und interdisziplinäre Behandlungskonzept der PTK. Die Veränderungen von motorischen und nichtmotorischen Symptomen nach drei Wochen und fünf Behandlungstagen in der PTK werden anhand objektiver Skalen präsentiert, und die subjektive Bewertung der Behandlung verschiedener Einzelaspekte (Konzept, Therapeuten, individueller Nutzen etc.) wird durch die Patienten dargestellt.
Ergebnisse Von den 334 Patienten mit PS (im Alter von 36 bis 87 Jahren mit Hoehn- und Yahr-Werten zwischen 1,0 und 4,5), die innerhalb eines Zeitraums von 32 Monaten in der PTK behandelt und evaluiert wurden, erhielten 309 Patienten die Diagnose eines idiopathischen Parkinson-Syndroms (IPS). Die Behandlung in der PTK führte zu einer Verbesserung der Motorik (MDS-UPDRS III; p < 0,05) und aller untersuchten nichtmotorischen Scores (BDI-II, MoCA, PDNMS, PDSS-2, KPPS, QUIP, PDQ-39; p < 0,05) und erzielte somit eine Verbesserung von Akinesie, Tremor, Dyskinesie, Kognition, Schlaf, Schmerzen, Impulskontrollstörungen und Lebensqualität. Auf einer 6-Punkte-Likert-Skala mit Schulnoten von 1 („sehr gut“) bis 6 („ungenügend“) bewerteten die Patienten ihre Behandlung in der PTK als positiv mit Noten von 1,3 bis 2,4 („sehr gut“ bis „gut“) je Kategorie sowie mit einer Gesamtnote von 1,5 („gut“).
Schlussfolgerungen Patienten mit fortgeschrittenem und / oder komplexem Parkinson-Syndrom profitieren vom Konzept der PTK, das eine Lücke zwischen stationärer und ambulanter Versorgung schließt.
Influenza – Krankheitslast und Impfprävention bei Kindern und Jugendlichen
Authors: Rose Markus A. 
Published: April 2020

ZUSAMMENFASSUNGInfluenza-ähnliche Atemwegsinfektionen sind eine weltweite bevölkerungsmedizinische Herausforderung. Die Vielfalt viraler Erreger lässt sich nicht klinisch unterscheiden, aber die Grippeschutzimpfung ist ein wichtiges Präventionsinstrument. Neben dem akut febrilen Krankheitsbild mit Myalgie, Zephalgie und Atembeschwerden müssen nicht-respiratorische Komplikationen (Influenza-assoziierte Myopathie, ZNS- oder kardiale Beteiligung) berücksichtigt werden. Aufgrund ständiger viral-genetischer Veränderungen und fehlendem Langzeitschutz bedarf es alljährlich neuer Influenzavakzine mit wissenschaftlichen und logistischen Herausforderungen. Die von Jahr zu Jahr unterschiedliche Schutzwirkung und teils auch Verträglichkeit jeweiliger Grippeimpfstoffe machen Impfkampagnen anspruchsvoll. Diese Übersicht stellt Krankheitslast, Wirksamkeit und Anwendungssicherheit zugelassener Influenzavakzine dar. Individuen mit allergischer Hühnerei-Sensibilisierung können unter Praxisbedingungen ohne zusätzliche Vorsichtsmaßnahmen grippegeimpft werden. Zukünftige Vakzine werden durch rekombinante oder Zellkultur-basierte Herstellungsverfahren besser verfügbar und möglicherweise noch wirksamer sein.
The importance of colonoscopy bowel preparation for the detection of colorectal lesions and colorectal cancer prevention
Authors: Sharma Prateek , Burke Carol A. , Johnson David A. , Cash Brooks D. 
Published: April 2020

Abstract
Background and study aims Colonoscopy for colorectal cancer (CRC) screening has reduced CRC incidence and mortality and improved prognosis. Optimal bowel preparation and high-quality endoscopic technique facilitate early CRC detection.This review provides a narrative on the clinical importance of bowel preparation for colonoscopy and highlights available bowel preparations.
Methods A PubMed search was conducted through June 2019 to identify studies evaluating clinical outcomes, efficacy, safety, and tolerability associated with bowel preparation for CRC screening-related colonoscopy.
Results Selecting the optimal bowel preparation regimen is based on considerations of efficacy, safety, and tolerability, in conjunction with individual patient characteristics and preferences. Available bowel preparations include high-volume (4 L) and low-volume (2 L and 1 L), polyethylene glycol (PEG) solutions, sodium sulfate, sodium picosulfate/magnesium oxide plus anhydrous citric acid, sodium phosphate tablets, and the over-the-counter preparations magnesium citrate and PEG-3350. These preparations may be administered as a single dose on the same day or evening before, or as two doses administered the same day or evening before/morning of colonoscopy. Ingesting at least half the bowel preparation on the day of colonoscopy (split-dosing) is associated with higher adequate bowel preparation quality versus evening-before dosing (odds ratio [OR], 2.5; 95 % confidence interval [CI], 1.9−3.4).
Conclusions High-quality bowel preparation is integral for optimal CRC screening/surveillance by colonoscopy. Over the last 30 years, patients and providers have gained more options for bowel preparation, including low-volume agents with enhanced tolerability and cleansing quality that are equivalent to 4 L preparations. Split-dosing is preferred for achieving a high-quality preparation.
Multicenter randomized trial of endoscopic papillary large balloon dilation without sphincterotomy versus endoscopic sphincterotomy for removal of bile duct stones: MARVELOUS trial
Authors: Kogure Hirofumi , Kawahata Shuhei , Mukai Tsuyoshi , Doi Shinpei , Iwashita Takuji , Ban Tesshin , Ito Yukiko , Kawakami Hiroshi , Hayashi Tsuyoshi , Sasahira Naoki , Kubota Kensuke , Togawa Osamu , Kato Hironari , Okabe Yoshinobu , Matsubara Saburo , Yagioka Hiroshi , Saito Tomotaka , Nakai Yousuke , Isayama Hiroyuki 
Published: April 2020

Abstract
Background Endoscopic papillary large balloon dilation (EPLBD) has been increasingly used for the management of large common bile duct (CBD) stones. Although EPLBD is often preceded by endoscopic sphincterotomy (EST), EPLBD alone without EST has been increasingly reported as an alternative to EST for large CBD stones.
Methods This multicenter randomized trial was conducted at 19 Japanese institutions to compare the efficacy and safety of EPLBD alone versus EST for the removal of large (≥ 10 mm) CBD stones. The primary end point was complete stone removal in a single session. The secondary end points included: overall complete stone removal, lithotripsy use, procedure time, adverse events, and cost.
Results 171 patients with large CBD stones were included in the analysis. The rate of single-session complete stone removal was significantly higher in the EPLBD-alone group than in the EST group (90.7 % vs. 78.8 %; P = 0.04). Lithotripsy use was significantly less frequent in the EPLBD group than in the EST group (30.2 % vs. 48.2 %; P = 0.02). The rates of early adverse events were comparable between the two groups: rates of overall adverse events were 9.3 % vs. 9.4 % and of pancreatitis were 4.7 % vs. 5.9 % in the EPLBD and EST groups, respectively. The procedure costs were $1442 vs. $1661 in the EPLBD and EST groups, respectively (P = 0.12).
Conclusion EPLBD without EST for the endoscopic treatment of large CBD stones achieved a significantly higher rate of complete stone removal in a single session compared with EST, without increasing adverse events.
Performance of the microINR Point-of-Care System: A Multicenter Clinical Trial
Authors: Refaai Majed A. , Shah Vinay , Fernando Ronald 
Published: April 2020

Abstract
Introduction There are limited publications about the microINR point-of-care (POC) system (iLine Microsystems). The current microINR POC system was compared with the ACL TOP 500 laboratory analyzer (Instrumentation Laboratory) and with the CoaguChek XS POC system (Roche Diagnostics).
Methods This study was performed at three United States medical centers. Sixty-eight nonanticoagulated normal donors and 245 warfarin anticoagulated patients were included. Testing was performed in duplicate using capillary blood samples for the POC systems and venous blood samples for the laboratory testing. Accuracy and imprecision were assessed.
Results Comparing microINR to ACL revealed a correlation coefficient (r) of 0.973, a slope of 1.00 (95% confidence interval [CI], 0.97–1.03), and an intercept of 0.08 (95% CI, 0.04–0.15). When compared with the CoaguChek XS, r was 0.977 with a slope of 0.92 (95% CI, 0.89–0.94) and an intercept of 0.15 (95% CI, 0.08–0.19). Predicted bias values at international normalized ratio (INR) 2.0, 3.5, and 4.5 were ≤ 5% against both references. Agreement with ACL was 97, 95, and 100% for the INR ranges of < 2.0 ± 0.40, 2.0 to 4.5 ± 20%, and ≥ 4.5 ± 25%, respectively. Agreement for the combined INR ranges was 96% against ACL and > 96% against the CoaguChek XS. The coefficient of variation of the microINR was 5.03% for INR < 2.0 and 4.68% for the therapeutic INR range 2.0 to 3.5.
Conclusion The microINR results demonstrate adequate imprecision and accuracy to both ACL and CoaguChek XS. This indicates that monitoring INR by this microINR POC system is reliable and acceptable for the management of warfarin therapy.
Cost Implications of Varying the Surgical Setting and Anesthesia Type for De Quervain Release Surgery
Authors: Stephens Andrew R. , Yu Ziji , Presson Angela P. , Tyser Andrew R. , Kazmers Nikolas H. 
Published: April 2020

Abstract
Background First extensor compartment release is a common surgical procedure that represents a financial burden to the health care system.
Questions/Purposes Study questions included (1) whether surgical encounter costs differ based upon surgical setting (operating room [OR] vs. procedure room [PR]) or (2) based upon anesthesia choice (local only, Bier's block [BB], monitored anesthesia care [MAC], or general [GA]) for De Quervain release (DQR).
Patients and Methods Consecutive adult patients undergoing isolated unilateral DQR at a single academic medical center were identified retrospectively by Current Procedural Terminology code (25000). Using our institution's information technology value tools, we calculated total direct costs for each surgical encounter. Costs were adjusted to January 2016 dollars using the Consumer Price Index, normalized using each participant's surgical encounter cost divided by the median cost in the PR group, then compared across each group using Kruskal–Wallis and Nemenyi's post hoc pair-wise tests. Multivariable gamma regression analysis with a log link was performed to identify factors associated with surgical costs. QuickDASH (disabilities of the arm, shoulder, and the hand) scores were compared using a t-test at final follow-up.
Results Among 58 included patients, 29% (17/58) were treated in the PR and 71% (41/58) in the OR. Compared with local only in the PR, all other groups were significantly more costly. Multivariable gamma regression indicated that use of OR/BB, OR/MAC, or OR/GA independently led to 211, 222, and 357% greater surgical costs as compared with the PR with local only while controlling for provider and patient age. Furthermore, QuickDASH scores were similar between PR and OR groups at final follow-up.
Conclusion Performing DQR in the PR setting under local only anesthesia yields greater value than the OR, as patient-reported outcomes are similar despite significantly lower surgical costs. Level of Evidence This is a Level III, cost analysis study.
Extracorporeal Cardiopulmonary Resuscitation in Acute Fulminant Myocarditis: A Case Report and Review of the Literature
Authors: Rodriguez-Coronado Jesus Andres , Saldivar-Martinez Jesus Arturo , Gomez-Gutierrez Rene Daniel , Quezada-Valenzuela Guillermo , Contreras-Cepeda Maria Veronica , Sanchez-Cortes Ramon Gerardo , Paz-Gonzalez Miguel A. , Castillo-Treviño Mario Alberto , Villarreal Enrique G. 
Published: April 2020

AbstractFulminant myocarditis is a life-threatening fast progressive condition. We present a 7-year-old female patient admitted with a diagnosis of acute myocarditis with a rapidly progressive cardiac dysfunction despite conventional vasoactive and inotropic treatment. The patient presented with ventricular fibrillation and subsequent cardiac arrest. Cardiopulmonary resuscitation (CPR) was performed during 105 minutes before extracorporeal membrane oxygenation (ECMO) cannulation was performed. Effective hemodynamic function was obtained, and ECMO was weaned after 7 days, without neurological complications. There are not established extracorporeal cardiopulmonary resuscitation (eCPR) treatment criteria, and some international guidelines consider up to 100 minutes of “low flow” phase as a time limit to start the support. Some mortality risk factors for ECMO treatment mortality are female gender, renal failure, and arrhythmias. Pre-ECMO good prognostic factors are high levels of pH and blood lactate.
The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children
Authors: Uğur Cüneyt , Madenci Hasan , Kurku Hüseyin , Neşelioğlu Salim 
Published: April 2020

Abstract
Objective The aim of this study was to determine the role of thiol/disulfide homeostasis (TDH) parameters which are new oxidative stress markers for the diagnosis of acute appendicitis (AA) in children with abdominal pain complaints.
Methods A total of 40 patients with AA and 45 patients with abdominal pain were included in this study. Two groups were compared in terms of age, gender, white blood cell count, neutrophil-to-lymphocyte ratio, C-reactive protein (CRP), appendix diameter, and TDH parameters (native and total thiol levels, native thiol/total thiol ratio [antioxidant parameters] and disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio [oxidant parameters]).
Results Compared with the abdominal pain group, it was found that disulfide level, disulfide/native thiol, and disulfide/total thiol ratios (p < 0.001 for all) in patients with AA were significantly higher and their native thiol level (p = 0.02) and native thiol/total thiol ratio (p < 0.001) were significantly lower. There was no significant difference between the two groups in terms of total thiol level. There was no significant difference between the perforated and nonperforated groups in patients with AA in terms of TDH parameters. In addition, the CRP level was higher in the perforated group than the nonperforated group.
Conclusion To our knowledge, the present study is a first in the literature in which TDH parameters were used in children with AA compared with the abdominal pain group. We thought that these parameters may be useful as new biomarkers supporting AA diagnosis in children.
Glutaric Aciduria Type 1: A Case Report and Review of Literature
Authors: Sanju Sidaraddi , Tullu Milind S. , Seshadri Nithya , Agrawal Mukesh 
Published: April 2020

AbstractAn 8-month-old male infant patient was referred to our institution (from elsewhere) with a history of fever, convulsions, dystonic posturing, altered sensorium, and loss of motor and mental milestones since past 1 month. Upon admission to our institution, a neuroimaging (magnetic resonance imaging of the brain) revealed frontoparietal atrophy, “bat-wing appearance,” and basal ganglia changes. Carnitine and acylcarnitine profile revealed low total carnitine, very low free carnitine, and low free/acylcarnitine ratio, with normal levels of plasma amino acids. Urine gas chromatography mass spectrometry showed an elevated level of ketones (3-hydroxybutyric acid and acetoacetate) and glutaric acid with the presence of 3-hydroxyglutaric acid, suggestive of glutaric aciduria type 1. Diet modification and pharmacotherapy with riboflavin and carnitine arrested the neurological deterioration in the patient.
Requesting here-and-now actions with two imperative formats in Korean
interaction
Authors: Kim Stephanie Hyeri , Kim Mary Shin 
Published: April 2020

Abstract
This chapter analyzes two Korean imperative formats, the
-e/a imperative and the imperative formed with the
auxiliary verb po‑ ‘see’ (referred to as the plain imperative and the pwa imperative, respectively), focusing on the requests of
here-and-now actions. Pwa imperatives are selected when the
nominated action is a step that advances the larger course of action in
progress and anticipates a next action, although the outcome of the
nominated action is only provisionally determined. Plain imperatives, on the
other hand, are deployed when no further actions are suggested as part of
the nominated action. The paper challenges the previous explanations based on social
distance or politeness by showing that the selection of the imperatives hinges on a particular
‘situation design’, that is, whether the nominated action is connected to
the larger action trajectory.
Linguistic structures emerging in the synchronization of a Pilates
class
Authors: Keevallik Leelo 
Published: April 2020

Abstract
This chapter targets grammar in the interactive process
between a Pilates teacher and the exercising students, an activity context
in which instruction and compliance can be designed to merge in time. It
shows how linguistic structure, such as counts, formula, and phrases,
emerges step-by-step sensitively to the others’ currently moving bodies. At
the same time, the situation-designed structures direct the students through
the partially known moves. In contrast to formal theories that consider
grammar as a device for coherent expression of propositions, this study
argues that grammatical structure emerges through recurrent use in a
specific activity context. The video-recorded data is in Estonian.
Multimodal mechanisms for mobilizing students to give pre-structured
responses in French L2 classroom interaction
Authors: Chazal Kirby 
Published: April 2020

Abstract
This study examines interactions in French L2 university
classroom discourse from a multimodal conversation analytic (CA)
perspective. In these interactions, a teacher mobilizes students to respond,
then evaluates and subsequently reveals their responses on digital slides as
a ratification of correct responses. As the co-participants build a joint
interactional history with this task, the teacher becomes increasingly more
reliant on embodied orientations toward the computer displaying the slides,
thereby helping to both manage and transition between sequences of
interaction. The findings provide insights into how the multimodal
management of pedagogical artifacts, such as digital slides, can work to
mobilize, evaluate and create interactional space for students to respond in
teacher-led interaction.
Excellent electronic transport in heterostructures of graphene and monoisotopic boron-nitride grown at atmospheric pressure
Authors: Sonntag J , Li J , Plaud A , Loiseau A , Barjon J , Edgar J H , Stampfer C 
Published: April 2020

Abstract
Hexagonal boron nitride (BN), one of the very few layered insulators, plays a crucial role in 2D materials research. In particular, BN grown with a high pressure technique has proven to be an excellent substrate material for graphene and related 2D materials, but at the same time very hard to replace. Here we report on a method of growth at atmospheric pressure as a true alternative for producing BN for high quality graphene/BN heterostructures. The process is not only more scalable, but also allows to grow isotopically purified BN crystals. We employ Raman spectroscopy, cathodoluminescence, and electronic transport measurements to show the high-quality of such monoisotopic BN and its potential for graphene-based heterostructures. The excellent electronic performance of our heterostructures is demonstrated by well developed fractional quantum Hall states, ballistic transport over distances around 10 µm at low temperatures and electron-phonon scattering limited transport at room temperature.
Instrument suite cost optimisation in a science megaproject
Authors: Bentley Phillip M 
Published: April 2020

Abstract
This article presents a cost optimisation study of neutron scattering instrumentation at the European Spallation Source (ESS) in Lund, Sweden. This is done by focusing on the main cost drivers for almost half of the instrument hardware—optics and shielding —and trading detailed cost functions against beam transmission functions in a multi-dimensional, yet simple, parameter space. A cost saving of almost 30% is identified. The method is demonstrated in a worked example on a mature instrument design, and there are no reductions in performance. The proposed solution is shown to correspond to a Nash equilibrium of simultaneous shielding and optics strategies, versus the baseline which is trapped by working through sequential strategies. Finally, this cost analysis is bench-marked against, and found to be in agreement with, the costs of operational facilities of a similar class.
Atomic resolution enabled STEM imaging of nanocrystals at cryogenic temperature
Authors: Tyukalova Elizaveta , Duchamp Martial 
Published: April 2020

Abstract
In this study, we address the problem of electron-beam induced damage on two energy-related materials: LiNi0.5Mn1.5O4 used as a cathode material for lithium-ion batteries and ZnCo1.8Ni0.2O4 used as a catalyst for oxygen evolution reaction. Both materials were found to transform from the spinel into the rocksalt phase while being imaged by high-resolution scanning transmission electron microscopy (HR-STEM) at room temperature. To mitigate the degradation, we found HR-STEM characterization at cryogenic temperature delays the critical electron dose for structural modification. We determined the native phase of materials to be spinel while the other phases observed by HR-STEM were induced by the electron-beam. From a careful analysis of the experimental data and a detailed understanding of the different degradation processes induced by an energetic electron beam, we conclude that radiolysis is the mechanism responsible for the degradation in LiNi0.5Mn1.5O4 and ZnCo1.8Ni0.2O4 nanoparticles.
Overview of cell motility-based sickle cell disease diagnostic system in shearing digital holographic microscopy
Authors: O’Connor Timothy , Anand Arun , Andemariam Biree , Javidi Bahram 
Published: April 2020

Abstract
We overview a previously reported low-cost, compact, and 3D-printed shearing interferometer system for automated diagnosis of sickle cell disease based on red blood cell (RBC) bio-physical parameters and membrane fluctuations measured via digital holographic microscopy. The portable quantitative phase microscope is used to distinguish between healthy RBCs and those affected by sickle cell disease. Video holograms of RBCs are recorded, then each video hologram frame is computationally reconstructed to retrieve the time-varying phase profile of the cell distribution under study. The dynamic behavior of the cells is captured by creating a spatio-temporal data cube from which features regarding membrane fluctuations are extracted. Furthermore, the Optical Flow algorithm was used to capture lateral motility information of the cells. The motility-based features are combined with physical, morphology-based cell features and inputted into a random forest classifier which outputs the health state of the cell. Classification is performed with high accuracy at both the cell level and patient level.