bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Brief Analysis on the Application and Influence of Financial Derivatives in Chinese Enterprises
Authors: Yuan Shuoji 
Published: December 2020

<p>This article is aimed to study the influence and the role of enterprise development of financial derivatives in China. At the same time, combining with the characteristics of Chinese enterprises, the article analyzed the present situation of the development of domestic financial derivatives market in China and the existing defects; the conclusion summarizes the enterprise using the measures and methods of the financial derivatives, right use of financial derivatives for China’s enterprise to provide the corresponding measures. Finally, the analysis shows that the correct use of financial derivatives can play a great role in the development and management of enterprises.</p>
O Emaranhado de Fios dos Relatos de Infância: o Gênero Autobiográfico em Recuerdos de Niñez y Mocedad de Miguel de Unamuno
Authors: OLIVEIRA NETO WALTER PINTO DE , LOBATO ANDREA TERESA MARTINS 
Published: December 2020

RESUMORecuerdos de niñez y mocedad (1908) é uma obra autobiográfica do escritor Miguel de Unamuno (1864 – 1936), na qual o autor narra diversas experiências da infância e adolescência. Nela, Unamuno aborda algumas lembranças que, por se manterem longe na distância e no tempo, confundem-se em fios emaranhados entre o real e o fictício. Para analisar o relato de infância do modernista espanhol, valemo-nos de estudiosos do gênero autobiográfico e psicanalistas como Braunstein (2008). Assim sendo, o estudo buscou analisar e encontrar traços do gênero autobiográfico na obra do intelectual, da mesma maneira que os recursos linguísticos para encobrir as camadas nebulosas da memória. Tendo por base estes preceitos, a partir da metodologia bibliográfica de cunho qualitativo, explicaremos como as recordações de Don Miguel, em Recuerdos de niñez y mocedad, são descritas vários anos após a infância ter se tornado, somente, “pontos que estão contidos em enormes espaços vazios”.Palavras-chave: Autobiografia. Infância. Unamuno. The threads' tangle of childhood relationships: the autobiographical gender in Recuerdos de niñez y mocedad by Miguel de UnamunoABSTRACT Recuerdos de niñez y mocedad (1908) is an autobiographical work by the writer Miguel de Unamuno (1864 – 1936), in which the author describes various experiences of childhood and adolescence. In it, Unamuno addresses some memories that, being far away in time and distance, get confused in tangled threads between the real and the fictional. To analyze the childhood report of the Spanish modernist, we will use autobiographical scholars and psychoanalysts such as Braunstein (2008). Therefore, the study sought to analyze and find traces of the autobiographical genre in the intellectual's work, as well as the linguistic resources to cover the foggy layers of memory. Based on these precepts, from the qualitative bibliographical methodology, we will explain how the memories of Don Miguel, in Recuerdos de niñez y mocedad, are described several years after childhood only became “points that are contained in huge empty spaces”.Keywords: Autobiography; Childhood; Unamuno.
Increasing Access to Buprenorphine in Safety-Net Primary Care Clinics: The New York City Buprenorphine Nurse Care Manager Initiative
Authors: Kaplan-Dobbs Marissa , Kattan Jessica A. , Tuazon Ellenie , Jimenez Christian , Saleh Sabina , Kunins Hillary V. 
Published: December 2020

The Buprenorphine Nurse Care Manager Initiative (BNCMI) sought to increase access to opioid use disorder treatment in underserved New York City populations by expanding buprenorphine treatment capacity in safety-net primary care clinics. During 2016 to 2020, BNCMI added 116 new buprenorphine providers across 27 BNCMI clinics, and 1212 patients were enrolled; most patients identified as Latinx or Hispanic and were Medicaid beneficiaries. BNCMI increased access to buprenorphine, reached underserved populations, and is part of the New York City Health Department’s multipronged approach to reducing opioid overdose deaths.
De Aristóteles a las políticas públicas de la felicidad en el Perú. Disquisiciones desde un estudio en dos estratos sociales
Authors: Ibáñez Franklin , Mateu Pedro , Zuñiga Javier , Vásquez Enrique 
Published: December 2020

En las últimas décadas la felicidad se ha convertido en un tema importante para diversas disciplinas y, desde allí, ha comenzado una reflexión por su posible aplicación a las políticas públicas. Un equipo interdisciplinario de investigadores ha recogido las ideas más comunes relacionadas con la felicidad en el Perú a partir de entrevistas a los jefes de hogar de los distritos más pobres y más ricos del país. El presente texto examinará tales resultados a partir de la teoría de Aristóteles, a fin de brindar fundamentos teóricos para posibles políticas públicas. La teoría clásica aristotélica es eudemonista permite distinguir entre concepciones más superficiales y profundas de la felicidad. Se concluye que políticas asociadas a la felicidad promueven una vida humana plena que comprende acceso a la salud, la educación, el empleo y la promoción de la solidaridad ciudadana. Se desmitifica también la idea de que los pobres sólo necesitan o desean dinero para ser felices.
Patient Characteristics Predict Patency of Early-Cannulation Arteriovenous Grafts
Authors: Kingsmore David , Stevenson Karen , Richarz Sabine , Isaak Andrej , Jackson Andrew , Kasthuri Ram , Thomson Peter 
Published: December 2020

Abstract
There is a new emphasis on tailoring appropriate vascular access for hemodialysis to patients and their life-plans, but there is little known about the optimal use of newer devices such as early-cannulation arteriovenous grafts (ecAVG), with studies utilising them in a wide variety of situations. The aim of this study was to determine if the outcome of ecAVG can be predicted by patient characteristics known pre-operatively. This retrospective analysis of 278 consecutive ecAVG with minimum one-year follow-up correlated functional patency with demographic data, renal history, renal replacement and vascular access history.

On univariate analysis, aetiology of renal disease, indication for an ecAVG, the number of previous tunnelled central venous catheters (TCVC) prior to insertion of an ecAVG, peripheral vascular disease, and BMI were significant associates with functional patency. On multivariate analysis the number of previous TCVC, the presence of peripheral vascular disease and indication were independently associated with outcome after allowing for age, sex and BMI.

When selecting for vascular access, understanding the clinical circumstances such as indication and previous vascular access can identify patients with differing outcomes. Importantly strategies that result in TCVC exposure have an independent and cumulative association with decreasing long-term patency for subsequent ecAVG. As such, TCVC exposure is best avoided or minimised particularly when ecAVG can be considered.
Propensity-score-matched Evaluation of Psychological Stress and Hair Cortisol among People Living with HIV in China
Authors: Chen Xu , Zeng Cheng-Bo , Liu Shuai-Feng , Li Xiao-Ming , Qiao Shan , Lv Ri-Ying , Shen Zhi-Yong 
Published: December 2020

Abstract
To compare the psychological stress level and hair cortisol level of people living with HIV (PLWH) with those without HIV. A total of 220 subjects were initially enrolled in the study, including 20 subjects living without HIV and 200 PLWH. Psychological stress level, including quality of life, anxiety, perceived stress and mental resilience, was self-reported in both groups with related scales. The cortisol in hair were extracted and assessed by LC-APCI-MS/MS method. Propensity score matching analysis was performed to balance the baseline covariates of the two groups, whereas the difference in psychological stress level and hair cortisol level between the two groups were compared. Furthermore, the associations between psychological stress level and cortisol level were examined. Two comparison groups were matched by 1:3 propensity score matching, which yield 20 subjects living without HIV and 60 PLWH. Ultimately, in regarding to the psychological stress, the levels of the anxiety, perceived stress and mental resilience were higher among PLWH than those living without HIV, but the people without HIV showed higher quality of life. The hair cortisol level in PLWH was higher than those living without HIV. However, there were no significant associations between psychological stress level and cortisol level. The PLWH showed higher level of psychological stress and cortisol than those without HIV. No relationship was seen between psychological stress level and cortisol level in PLWH.
Prediction of Unsuccessful Endometrial Ablation: Random Forest vs Logistic Regression
Authors: Stevens Kelly Yvonne Roger , Lagaert Liesbet , Bakkes Tom , Gelderblom Malou Evi , Houterman Saskia , Gijsen Tanja , Schoot Benedictus 
Published: December 2020

Abstract
Background: Five percent of premenopausal women experience abnormal uterine bleeding. Endometrial ablation (EA) is one of the treatment options for this common problem. However, this technique shows a decrease in patient satisfaction and treatment efficacy on the long term Study objective: To develop a prediction model to predict surgical re-intervention (for example re-ablation or hysterectomy) within two years after EA by using Machine Learning (ML). The performance of the developed prediction model was compared with a previously published multivariate logistic regression model (LR). Design: This retrospective cohort study, with a minimal follow up time of two years, included 446 pre-menopausal women (18+) that underwent an EA for complaints of heavy menstrual bleeding. The performance of the ML- and the LR model was compared using the area under the Receiving Operating Characteristic (ROC) curve. Results: We found out that the ML model (AUC of 0.65 (95% CI 0.56-0.74)) is not superior compared to the LR model (AUC of 0.71 (95% CI 0.64-0.78)) in predicting the outcome of surgical re-intervention within two years after EA. Conclusion: Although Machine Learning techniques are gaining popularity in development of clinical prediction tools, this study shows that ML is not necessarily superior to the traditional statistical LR techniques. The performance of a prediction model is influenced by the sample size, the number of features of a dataset, hyperparameter tuning and the linearity of associations. Both techniques should be considered when developing a clinical prediction model.
Optical scatterings in layered systems
Authors: Liu Chang-Ting , Chiu Chih-Wei , Lin Chiun-Yan , Lin Ming-Fa 
Published: December 2020

Abstract
Optical properties, reflectance, absorbance and transmittance spectra, are fully investigated for the layered structures through the development of theoretical framework. The transverse dielectric function, which characterizes the dynamic charge screenings, can cover all the intralayer and interlayer atomic interactions under the electro-magnetic wave perturbation. By the continuous reflection and transmission scatterings at two surfaces, their analytic formulas are established from the vertical valence-state transitions and the boundary conditions. They are also suitable for finite-width bulk materials. Most important, this study is fully combined with the generalized tight-binding model with all the intrinsic interactions and external field.
Bibliometric Analysis of Literature on Acute Respiratory Distress Syndrome Treatments Published Between 2000 and 2019
Authors: Wang Zong-Yu , Zhou Zhi-Chao , Zheng Jie , Cong Zhu-Kai , Zhu Xi 
Published: December 2020

Abstract
Background: Acute respiratory distress syndrome (ARDS) is a common and extensively researched condition, and treatment modalities are continuously being developed and improved. Although the literature on ARDS treatment is vast, there have not been any bibliographic analyses examining trends in this area. We aimed to systematically evaluate the literature on ARDS treatments published between 2000 and 2019, from the perspective of bibliometrics.Methods: Literature retrieval was performed in PubMed and in the Web of Science Core Collection, and analyzed for publication and temporal trends. CiteSpace was used to perform co-occurrence analysis for institutions, and reference co-citation analysis for research topics. Burst keyword detection was used to predict future areas of research interest in the field.Results: A total of 13,933 articles were retrieved. The journal Critical Care Medicine published the largest number of articles (956, 6.86%). The University of Toronto was affiliated with the most publications (574, 4.28%) and had the highest degree of betweenness centrality, indicating extensive inter-institution collaboration. The papers on ARDS treatment published between 2000 and 2019 were grouped into 10 major clusters, 3 of which indicated recent activity (“acute lung injury,” “long-term outcome” and “extracorporeal membrane oxygenation”). Fifteen burst keywords/terms were identified, including extracorporeal membrane oxygenation, meta-analysis and oxidative stress.Conclusions: On the basis of the literature published in the preceding 20 years, the exploration of ARDS treatment is an ongoing concern. Extracorporeal membrane oxygenation was an active focus of research in this field. It and oxidative stress are likely to become major topics of research interest in the near future. Meta-analysis will be a popular method in analyzing the efficacy of ARDS treatments.
Setting-Up A Cross-Border Action-Research Project to Control Malaria in Remote Areas of the Amazon: Describing the Birth and Milestones of A Complex International Project (Malakit)
Authors: Galindo Muriel Suzanne , Lambert Yann , Mutricy Louise , Garancher Laure , Miller Jane Bordalo , Gomes José Hermenegildo , Sanna Alice , Peterka Cassio , Hilderal Hélène , Cairo Hedley , Hiwat Helene , Nacher Mathieu , Suárez-Mutis Martha Cecilia , Vreden Stephen , Douine Maylis 
Published: December 2020

Abstract
Background: In French Guiana, gold miners working illegally represents a major reservoir of malaria. This mobile population, mainly of Brazilian descent, enters the French Guianese forest from neighboring countries, Suriname and Brazil. A complex and innovative intervention was piloted in cooperation with the three involved countries to control malaria in this specific population. The principle was to provide participants through health workers called “facilitators” with a self-diagnosis and self-treatment kit along with adequate training and material to rapidly manage an episode of malaria symptoms on their own, when they find themselves isolated from health care services. Method: We describe here the design, development, content of the intervention and players’ organization of this multi-country project, the opportunities and constraints encountered, and the lessons learnt at this stage. Results: We chose not to implement a usual “Test and Treat” approach within the community mainly for regulatory reasons. The content of medical messages tend to balance the tension between thoroughness, accuracy and efficacy. The wide range of tools developed through a participatory approach was intended to cope with the challenges of the literacy level of the target population. Despite the difficulties encountered due to language, regulation differences and distance between partners, cooperation was fruitful, due to the complementary of stakeholders, their involvement at all important stages and regular face-to-face meetings. Discussion and conclusion: This experience shows the feasibility of an ambitious project of action-research in a border malaria context, involving several countries and with a mobile and undocumented population. It reveals some factors of success which may be transferable in analogous settings.
The Possible Role of Interleukin-6 as a Regulator of Insulin Sensitivity in Patients With Neuromyelitis Optica Spectrum Disorder
Authors: Maghbooli Zhila , Moghadasi Abdorreza Naser , Rezaeimanesh Nasim , Omidifar Abolfazl , Varzandi Tarlan , Sahraian Mohammad Ali 
Published: December 2020

Abstract
Background: The aquaporin 4- Immunoglobulin G (AQP4-IgG) is the disease-specific autoantibody that has a significant role in the pathogenesis of Neuromyelitis optica spectrum disorder (NMOSD). Circulating AQP4-IgG induces pro-inflammatory cytokines and may also trigger downstream signaling pathways leading to metabolic dysregulation.Methods: We aimed to determine the risk association of hyperinsulinemia in NMOSD patients with seropositive AQP4-IgG and the serum levels of interleukin (IL)-6 and IL-17 compared with the control group.Serum levels of metabolic (Insulin, Fasting Blood Sugar (FBS), lipid profile) and inflammatory (IL-6 and IL-17) markers were assessed in 56 NMOSD patients and 100 controls.Results: Hyperinsulinemia was more prevalent in NMOSD patients independent of age, gender and body mass index (BMI) (48.2% vs. 26%, p=0.005). After adjusting age, sex and BMI, there was significant association between lower insulin sensitivity (IS) and NMOSD risk (95% CI: Beta=0.73, 0.62 to 0.86, p=0.0001).The correlation between the duration of disease and circulating levels of insulin and FBS in NMOSD patients was not significant (P>0.05). Circulating levels of IL-6 and IL-17 were higher in NMOSD patients, and only IL-6 had an effect modifier for the association between lower insulin sensitivity and NMOSD risk. Conclusions: Our data suggests that inflammatory pathogenesis of NMOSD leads to hyperinsulinemia and increases the risk of insulin resistance.
Decreased endometrial thickness between HCG day and embryo transfer day improves the pregnancy rate of IVF/ICSI cycles
Authors: Wang Miao , Deng Huali , Wang Xinglin , Zhang Lihong , Wang Fang , Ye Hong 
Published: December 2020

Abstract
Background

Previous studies have suggested that pregnancy outcome and endometrial thickness before embryo transfer are closely related. However, we found that endometrial thickness changed even within a few days between HCG day and embryo transfer day. There have been few studies on the relationship between endometrial thickness change (ETC) and pregnancy outcomes. The aim of this study was to assess whether the ETC from HCG trigger day to embryo transfer day affects pregnancy outcomes of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.
Methods

This was a retrospective single-center cohort study. In total, 9773 IVF/ICSI embryo transfer cycles involving the long protocol at Chongqing Reproductive and Genetics Institute from January 1st, 2016, to December 30th, 2019, were included. The 9773 cycles were divided into 2 groups based on whether the endometrial thickness decreased from HCG day to embryo transfer day, and clinical pregnancy rates (CPRs) and ongoing pregnancy rates (OPRs) were compared. Logistic regression was used to determine whether an ETC was an independent risk factor for CPR or OPR.
Results

The CPR and OPR of the decreased endometrial thickness group were higher than those of the non-decreased endometrial thickness group (62.65% and 52.6% vs. 60.56% and 50.18%) (p = 0.041 vs. 0.027). The endometrial thickness change was an independent risk factor for CPR (OR = 0.920, P = 0.003, 95% confidence interval 0.870–0.972) and OPR (OR = 0.907, P = 0.000, 95% confidence interval 0.859–0.958)
Conclusions

A proper decrease in endometrial thickness from HCG trigger day to embryo transfer day in IVF/ICSI cycles increases the CPR and OPR.
Peruvoside is a new Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways
Authors: Lai Yi-Hua , Chang Hsiu-Hui , Chen Huei-Wen , Chang Gee-Chen , Chen Jeremy JW 
Published: December 2020

Abstract
Background

The tyrosine kinase Src plays an essential role in the progression of many cancers and is involved in several signalling pathways regulated by EGFR. To improve the efficacy of lung cancer treatments, this study aimed to identify novel compounds that can disrupt the Src-EGFR interaction to inhibit lung cancer progression and are less dependent on the EGFR mutation status than other compounds.
Methods

We used Src pY419 ELISA as the drug-screening platform to screen a compound library of more than 400 plant active ingredients and identified peruvoside as a candidate Src-EGFR crosstalk inhibitor. Human Non-small cell lung cancer cell lines (A549, PC9, PC9/gef, H3255 and H1975) with different EGFR statuses were used to perform cell cytotoxicity and proliferation assays after peruvoside or dasatinib treatment. Src and Src-related protein expression was evaluated by western blotting in peruvoside-treated A549, H3255 and H1975 cells. The effects of peruvoside on cancer cell function were assessed in A549 cells. The synergistic effects of gefitinib and peruvoside were assessed by CI-isobologram analysis in gefitinib-resistant cell lines. The efficacy of peruvoside in vivo was determined using nude mice subjected to compound or vehicle treatments.
Results

Peruvoside significantly suppressed the phosphorylation of Src, EGFR, and STAT3 in a dose- and time-dependent manner and somewhat suppressed their protein expression. Cell function assays revealed that peruvoside also inhibited the proliferation, invasion, migration, and colony formation of lung cancer cells in vitro and tumour growth in vivo. Furthermore, peruvoside sensitised gefitinib-resistant tumour cells (A549, PC9/gef and H1975) to gefitinib treatment, indicating that it may exert synergistic effects when used in combination with established therapeutic agents. Our data also demonstrated that the inhibitory effects of peruvoside on lung cancer progression might be attributed to its ability to regulate multiple proteins, including Src, PI3K, JNK, Paxillin, p130cas, and EGFR.
Conclusions

Our findings suggest that peruvoside suppresses Non-small cell lung cancer malignancy by downregulating multiple Src-related pathways and may help develop new anticancer drugs and therapeutic strategies for lung cancer in the future.