bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fusicoccin: A Chemical Modulator for 14-3-3 Proteins
Authors: Ohkanda Junko 
Published: October 2020

Abstract
Diterpene glucoside fusicoccin A (FC-A) is a phytotoxic fungal metabolite that stabilizes the interactions between 14-3-3 protein and phosphorylated ligand protein. 14-3-3-mediated protein binding is central to the regulation of the serine/threonine kinase signaling pathway in all eukaryotic cells and is essential for controlling numerous biological processes. Thus, fusicoccins could serve as a robust platform for developing new chemical probes and pharmaceuticals. This review describes recent progress toward understanding the biosynthetic pathways of fusicoccins and the rational design of 14-3-3 inhibitors and stabilizers, as well as their antitumor activities.
Effect of energy drink consumption on baroreceptor sensitivity in young normal weight and overweight/obese males
Authors: Majeed Farrukh , Yar Talay , Alsunni Ahmed A , AlHawaj Ali F , AlRahim Ahmed A 
Published: October 2020

Objectives: There is lack of evidence exploring sympathetic effect by baroreceptor sensitivity in obese consuming energy drink. The purpose of this study was to investigate the acute effect of energy drink on individuals baroreceptor sensitivity in young healthy normal weight and overweight/obese males.
Methods: This cross-sectional study was performed in the Department of Physiology, Imam Abdulrahman Bin Faisal University, Kingdom of Saudi Arabia. After getting ethical approval, 25 male participants were recruited by convenient sampling and informed consent was obtained. Participants were grouped into normal weight and overweight/obese on basis of body mass index. Finger arterial blood pressure was recorded with Finometer® at baseline, 30min and 60 minutes in the post-energy drink period and baroreceptor sensitivity was calculated. As data was not normally distributed it was log transformed.
Results: The baseline baroreceptor sensitivity was lower (P<0.05) in overweight/obese compared to normal weight participants. Baroreceptor sensitivity reduced significantly (P<0.05) at 60 minutes after energy drink consumption in the whole cohort of both normal weight and overweight/obese. Baroreceptor sensitivity remained lower in overweight/obese compared to normal weight at 60min but the difference was not significant.
Conclusion: Consumption of energy drink acutely reduced baroreceptor sensitivity in both normal weight and obese young healthy males with an earlier onset of effect in overweight/obese indicating enhanced sympathetic activity. Energy drinks consumption could place the obese in a more vulnerable state to hypertension and arrhythmia.
doi: https://doi.org/10.12669/pjms.36.7.2419
How to cite this:Majeed F, Yar T, Alsunni AA, AlHawaj AF, AlRahim AA. Effect of energy drink consumption on baroreceptor sensitivity in young normal weight and overweight/obese males. Pak J Med Sci. 2020;36(7):1590-1595. doi: https://doi.org/10.12669/pjms.36.7.2419
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Lane’s Algorithm Revisited
Authors: Goycoolea Marcos , Lamas Patricio , Pagnoncelli Bernardo K. , Piazza Adriana 
Published: October 2020

In 1964, Kenneth Lane proposed an algorithm to optimize the production schedule of a single-metal, single-processor open pit mine. For this, he proposed a policy based on varying, over time, the so-called “cutoff grade”—or grade threshold used to determine if extracted material should be ore (processed material) or waste (thrown away). Lane’s algorithm had a profound impact on the mining industry. However, though it has been used in multiple commercial software systems and has traditionally been taught to every aspiring mining engineer, it is widely considered a heuristic, and little is known regarding the quality of the solutions it produces. In this paper, we formally study Lane’s problem. We show that Lane’s algorithm can be viewed as an approximate dynamic programming scheme and that Lane’s optimality conditions can be formally derived in two different ways: by considering a variant of the problem where the future value function is linearly approximated or by deriving the optimality conditions of a continuous-time version of the problem. We further show that Lane’s algorithm can naturally be extended to this continuous-time version of the problem and that when this algorithm converges, it converges to an optimal solution. Finally, through a reformulation, we show that Lane’s original problem can be solved using convex mixed-integer programming. Though hypothetical counterexamples can be constructed, computational experiments prove that Lane’s algorithm can produce the optimal solution in every real-world data set tested, thereby lending solid support for its practical application. This paper was accepted by Chung Piaw Teo, optimization.
Tree Cover Number and Maximum Semidefinite Nullity of Some Graph Classes
Authors: Domagalski Rachel , Narayan Sivaram 
Published: October 2020

Let $G$ be a graph with a vertex set $V$ and an edge set $E$ consisting of unordered pairs of vertices. The tree cover number of $G$, denoted $\tau(G)$, is the minimum number of vertex disjoint simple trees occurring as induced subgraphs of $G$ that cover all the vertices of $G$. In this paper, the tree cover number of a line graph $\tau(L(G))$ is shown to be equal to the path number $\pi(G)$ of $G$. Also, the tree cover numbers of shadow graphs, corona and Cartesian product of two graphs are found.
The graph parameter $\tau(G)$ is related to another graph parameter $M_+(G)$, called the maximum semidefinite nullity of $G$. Suppose $S_+(G,\mathbb{R})$ denotes the collection of positive semidefinite real symmetric matrices associated with a given graph $G$. Then $M_+(G)$ is the maximum nullity among all matrices in $S_+(G,\mathbb{R})$. It has been conjectured that $\tau(G)\leq M_+(G)$. The conjecture is shown to be true for graph classes considered in this work.
Reconfigurable terahertz switch using flexible L-shaped metamaterial
Authors: Lu Fangyuan , Ou Huiliang , Lin Yu-Sheng 
Published: October 2020

The design of a reconfigurable terahertz (THz) switch by using flexible L-shaped metamaterial (FLM), which is composed of dual-layer L-shaped metamaterials on polydimethylsiloxane substrate, which has three resonances at 0.57, 1.05, and 1.52 THz, is presented. By stretching the FLM along the

x

-axis direction, the transmission intensity is increased gradually at the transverse electric mode (TE) and reduced at the transverse magnetic (TM) mode, respectively. Reversely, by stretching the FLM along the

y

-axis direction, the transmission intensity is reduced gradually at the TE mode and increased at the TM mode, respectively. These electromagnetic responses of FLM provide the optical-logic behaviors with programmable characteristics by stretching FLM at different polarized light. It indicates that the proposed FLM could be used for the dual/triple-band switching, polarization switching, and programmable switching applications.
A Pedagogical Approach to Integrative Neuromuscular Training to Improve Motor Competence in Children: A Randomized Controlled Trail
Authors: Font-Lladó Raquel , López-Ros Víctor , Montalvo Alicia M. , Sinclair Graham , Prats-Puig Anna , Fort-Vanmeerhaeghe Azahara 
Published: October 2020

ABSTRACT
Font-Lladó, R, López-Ros, V, Montalvo, AM, Sinclair, G, Prats Puig, A, and Fort-Vanmeerhaeghe, A. A pedagogical approach to integrative neuromuscular training to improve motor competence in children: a RCT. J Strength Cond Res 34(11): 3078–3085, 2020—To assess the effectiveness of a pedagogical approach to an integrative neuromuscular training (INT) program as a warm-up in physical education (PE) lessons in healthy children: (a) to improve the level of motor competence (MC) and (b) to master fundamental motor skills (FMS) patterns, considering the baseline MC level and the time spent when performing different motor tasks. One hundred ninety students (7.43 ± 0.32 years; 52% girls) were included in this randomized controlled trail and grouped up according to MC basal levels (L1-L4). Motor competence and FMS patterns (CAMSA protocol) were assessed before and after the intervention in a group-based INT warm-up (n = 97) and a group-based conventional warm-up (n = 93). The INT program improved MC (p < 0.001; d = 0.71) and FMS (p < 0.001, d = 0.52). The independent predictors of MC change were: baseline MC level (β = −196; p < 0.012), time spent to perform the task (β = −0.235 p < 0.003), and participation in the INT program (β = 0.201; p < 0.005), explaining 71% of its variability. The INT warm-up shows correlations between improvements in MC in relation to time reduction (L1 p = 0.016, d, L2 p = 0.001, and L4 = 0.001) and FMS patterns (L1 p < 0.001, L2 p < 0.003, L3 p < 0.005, and L4 < 0.001) Moreover, only L3, it showed correlation between changes in time and FMS mastery (p = 0.001). Our results showed that a pedagogical approach to an INT program developed as a warm-up in primary school PE lessons can improve MC and FMS patterns in all subjects, independent of the initial MC level. More interestingly, only in L3, the improvement in MC can be explained by the balance in time required to perform the task and the level of improvement in FMS patterns.
Relação entre Cinismo e Expectativa de Trapaça na Vida Acadêmica e Profissional
Authors: Nasu Vitor Hideo , Afonso Luis Eduardo 
Published: October 2020

Objetivo: Analisar a relação entre o cinismo e a expectativa de trapaça nas vidas acadêmica e profissional de estudantes de cursos de pós-graduação lato sensu da área contábil.
Método: Empregaram-se questionários eletrônicos e in loco, com participação total de 92 alunos. O questionário estava dividido em três partes: (i) informações sociodemográficas do participante; (ii) questões para mensurar o construto de cinismo, mensurado de duas formas e denominado de CIN1 e CIN2; e (iii) questões sobre o comportamento e expectativa de trapaça na vida acadêmica e profissional dos participantes.
Resultados: Os testes iniciais indicaram que o nível de cinismo dos participantes é similar quando analisados por sexo, área em que trabalham e formação acadêmica. Os modelos de regressão logística binária indicaram que há relação positiva entre o cinismo e a expectativa de trapaça, tanto na vida acadêmica como na profissional.
Contribuição: Contribui-se com a discussão, ainda escassa, sobre o traço de cinismo no contexto de contabilidade brasileiro, fornecem-se evidências de que há relação positiva entre o cinismo na vida acadêmica, mas também na vida profissional, e alerta-se para o cinismo dos indivíduos para que políticas e códigos de conduta sejam adotados a fim de reduzir a trapaça em decorrência do cinismo.
Proses Pengambilan Keputusan Nasabah Bank Syariah Dalam Memilih Produk Pembiayaan Kepemilikian Rumah (Studi Kasus Nasabah Bank Muammalat KCI Darmo Surabaya)
Authors: Putra Bima Kurnia , Hasib Fatin Fadhilah 
Published: October 2020

The purpose of this research is to find out the decision making process of the customer of Muamalat Bank in choosing mortgage product. The process comprises problem recognition, information search, evaluation of alternatives, product choice, and the outcomes.A qualitative approach is applied in this research with the descriptive case study method. The collection of data uses purposive sampling to determine the key informant and uses snowballing sampling to determine the informants. The key informant in this research is an employee of Muamalat Bank. Meanwhile the infomants consist of four customers of Muamalat Bank. Two of them take murabahah contract and the rest takes musyarakah mutanaqisah contract. The collection of data is conducted through several steps including comprehensive exploration, focus exploration, and confirmation step. The data analysis in this research uses domain, taxonomic and componential analysis.The result of this research shows that both the murabahah and musyarakah mutanaqisah customers had already passed through five steps in decision making process comprises problem recognition, information search, evaluation of alternatives, product choice, and outcomes. The difference between two of them is revealed in the problem recognition and the product choice. The customer choose the mortgage contract based on some features.
Pengaruh Motivasi Terhadap Komitmen Organisasional Pada Guru Madrasah Ibtidaiyah Islamiyah Kota Madiun
Authors: Yudha Elit Prambara , Hasib Fatin Fadhilah 
Published: October 2020

This study aimed to investigate the effect of motivation to organizational commitment of teacher. This research uses questionaire as the primary data and the samples are 67 teachers and candidates of MI Islamiyah Madiun.this research uses quantitative approach with multiple linear regression as the analysis method.Based on the findings, it obtained multiple linear regression equation : Y = -0,460 + 0,666X1 + 0,473X2. The result reveals that motivation affect positively and significantly to the organizational commitment of teachers in Madrasah Ibtidaiyah Islamiyah Madiun. It is known from the calculated F vakue of 105,532 with a significance level (probability) of 0,000. Value of the variable t test Motivator and Hygiene partial effect on organizational commitment of teacher in MI Islamiyah Madiun significance level <0,05.MI Islamiyah should maintenance motivation of teachers, especially to endure the motivator factors and improve the hygiene factors to achieve organizational commitment of teachers in MI Islamiyah Madiun.
Faktor Yang Mempengaruhi Petani Bawang Merah Tidak Memilih Pembiayaan Pada Bank Syariah di Nganjuk
Authors: Pratiwi Anantika Hanum , Prasetyo Ari 
Published: October 2020

This research purposes to determine the factors that affect onion farmers not choose financing in Sharia Banking in Nganjuk. Right now, in Sharia Banking showed rapid development but not matched by the number of customers, especially financing customers the onion farmers in Nganjuk.This research uses a quantitative approach using exploratory factor analysis. Population characteristics of this research are the onion farmers in the Ngrami village and Sukomoro Subdistrict. The number of samples during the preliminary test by conducting a written interview on 10 respondents and to the main test required 100 respondents also. The sampling technique used is purposive sampling. Results of this research showed that there are four factors affected onion farmers not to choose financing in Sharia Banking in Nganjuk. Four those factors as a result of reduction of processing factor analysis. The four factors are named with the recommendations of other factors, another competitor, locations, and popularity. Suggestion for Sharia Bank are to socialize, provide products financing in the form of seasonal for farmers, by proactive services to potential customers, and services through a car arround in a place easily accessible public. Factors that are formed in this research also can be used to further research for influence the other variables, the decision did not choose to become sharia banking customers as a whole, not only on financing customers. In addition to further research the SUbject of research is expected to wider scope.
Pengaruh Bauran Pemasaran Terhadap Niat Menjadi Mitra Perspektif Islam Pada BMT Beringharjo Cabang Madiun
Authors: Tyas Mega Ayuning , Prasetyo Ari 
Published: October 2020

This study aims to analyze The Effect of Marketing Mix Towards Intention become Partner on Perspective of Islam at The Branch Office of BMT Beringharjo in Madiun. The tests carried out using multiple linear regression method, where the endogenous variable (Y) is a intention become partners and exogenous variables (X) is the marketing mix that is identified with product (X1), price (X2), place/distribution channel (X3), promotion (X4), people (X5), process (X6), physical evidence (X7), promise (X8), and patience (X9). In this study added two variables in the marketing mix of services in accordance with Islamic values that promise and patience.This study uses a quantitative approach. The characteristics of the population in this studi is a partner at The Branch Office of BMT Beringharjo in Madiun are actively engaged in transactions in 2014 and live in Madiun. Total sample of the respondents is 100 (one hundred). These samples were selected using nonprobability sampling with purposive sampling method with particular consideration.The results of this study indicate that simultaneous and partially, marketing mix variables consisting of product, price, place/distribution channel, promotion, people, process, physical evidence, promise, and patience shown the effect to intention become a partner on perspective of Islam at the branch office of BMT Beringharjo in Madiun. Variable place/distribution channel is the most dominant variable to the intention become partners on perspective of Islam at the branch office of BMT Beringharjo in Madiun.Suggestion for the branch office of BMT Beringharjo in Madiun should increase promotional activity to be more diverse so it can attract attention to prospective partners or partners who have joined, socialize product from BMT Beringharjo more clearly and detail, especially the difference with the product from conventional bank, and make a direct sales pitch way more exciting and creative by adding facilities and infrastructure in the promotion or by making a series of interesting activities and carried out in the crowd with direct sales activities.
Risk factors for discontinuation of exclusive breast feeding within 1-month: A retrospective cohort study
Authors: Yasuda Shun , Fukuda Toma , Toba Naoya , Kamo Norihito , Imaizumi Karin , Yokochi Midori , Okawara Tomoko , Takano Seiko , Yoshida Hideko , Kobayashi Nobuko , Kudo Shingo , Miyazaki Kyohei , Hosoya Mamiko , Sato Kenichi , Takano Kei , Kanno Aya , Murata Tsuyoshi , Kyozuka Hyo , Yamaguchi Akiko , Ito Fumihiro , Oda Shinichiro , Momoi Nobuo , Hosoya Mitsuaki , Fujimori Keiya 
Published: October 2020

Abstract
Background: While breastfeeding provides both optimal nutrition for infants and health benefits for the mother, many women either do not breastfeed or terminate breastfeeding earlier than recommended. The aim of this analysis was to identify factors associated with early discontinuation of breastfeeding in Japanese women.Methods: This study utilized medical records from the Iwase General Hospital in Fukushima Prefecture, Japan to assess cessation of breastfeeding by the 1-month postpartum appointment. Demographic, medical, and family predictors among 734 women who had initiated breastfeeding during their delivery hospital stay were examined, and multiple logistic regression was used to determine significant predictors of early cessation of exclusive breastfeeding.Results: In a bivariate analysis, it was observed that women who were primipara, unmarried, smoked before pregnancy, were exposed to secondhand smoke, employed, and/or had asthma were more likely to discontinue exclusive breastfeeding. Infant factors associated with discontinuation were lower birthweight, earlier gestational age, neonatal intensive care unit admission, treatment for jaundice, or lower weight gain. In multivariable analysis, primiparity, smoking before pregnancy, maternal employment and neonatal jaundice therapy remained associated with discontinuation of breastfeeding.Conclusions: Several maternal factors are associated with discontinuation of exclusive breastfeeding. In particular, women who smoke before pregnancy may need to be targeted for additional support for breastfeeding.
Vitamin C ameliorates tetrahydrocannabinol-induced spermatotoxicity in-vitro
Authors: Alagbonsi Abdullateef Isiaka , Olayaki Luqman Aribidesi 
Published: October 2020

Abstract
Background: We investigated the in-vitro effects of vitamin C on delta-9-tetrahydrocannabinol (THC) -induced reduction in spermatozoa motility and kinematics. Methods: Six rats were used for the study. Semen from each of the 6 rats was randomly divided into 6 groups such that each rat’s semen was in all of the groups. Groups I-III received placebo, THC (1 mM), and vitamin C (5 mM) respectively. Group IV was pretreated with cannabinoid receptors’ blockers (CBs-) 1 and 2, followed by THC. Groups V and VI received THC and vitamin C, but group VI was additionally pre-treated with CBs-. Results: The spermatozoa progressive motility, average path velocity (VAP), curvilinear velocity (VCL), straight-line velocity (VSL), amplitude of lateral head (ALH) and beat cross frequency (BCF) were reduced by THC (6.08±1.16%; 5.64±0.82 µm/s; 6.96±0.74 µm/s; 2.75±0.23 µm/s; 0.31±0.02 µm; and 0.78±0.08 Hz respectively) but increased by vitamin C (51.20±1.32 %; 17.90±0.21 µm/s; 25.11±0.96 µm/s; 8.80±0.27 µm/s; 0.75±0.01 µm; and 3.15±0.03 Hz respectively) when compared to control (39.72±0.38 %; 13.70±0.29 µm/s; 18.04±0.58 µm/s; 7.54±0.34 µm/s; 0.65±0.02 µm; and 2.79±0.01 Hz respectively). Vitamin C inhibited the THC-induced reduction in these parameters (37.36±0.73 %; 10.98±0.45 µm/s; 13.58±0.30 µm/s; 7.11±0.22 µm/s; 0.58±0.01 µm; and 2.60±0.01 Hz respectively) in the absence of CBs- 1 and 2, and even caused additional increases in progressive motility (49.54±1.01 %), VAP (15.70±0.38 µm/s) and VCL (22.53±0.29 µm/s) above the control levels with CBs-.Conclusion: Vitamin C ameliorates the THC-induced reduction in spermatozoa motility in-vitro by modulation of their kinematics.