bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fault frequency band segmentation and domain adaptation with fault simulated signal for fault diagnosis of rolling element bearings
Authors: Park Jongmin , Yoo Jinoh , Kim Taehyung , Kim Minjung , Park Jonghyuk , Ha Jong Moon , Youn Byeng D 
Published: December 2024

Abstract
Rolling element bearings are vital components in rotating machinery, and ensuring their reliable operation through robust fault diagnosis is crucial in industrial settings. Deep-learning-based methods have shown promise due to their high accuracy, but they often face challenges in data acquisition and domain shifts between training and inference datasets. Existing approaches have attempted to address these issues through signal generation using simulation models, deep learning techniques, and domain adaptation under partial label scenarios. However, generated signals often lack plausibility or physical fidelity, and partial domain adaptation approaches frequently fail to incorporate fault-related knowledge. This paper proposes a novel method combining fault frequency band segmentation domain adaptation (FBSDA) with fault-added and uncertainty-aware signal simulation. To address the scarcity of fault-labeled signals, the proposed simulation method accounts for uncertainties in the signal acquisition environment by leveraging statistical cyclo-stationary modeling of fault bearings. By adding simulated fault signals to normal signals that contain system characteristic information, the generated signals more accurately reflect real-site environments and physical principles. Additionally, the FBSDA method, a domain adaptation approach focusing on segmenting fault-related information within the fault frequency band, is introduced. To enhance the focus on the fault frequency band, FBSDA employs a fault frequency segmentation module and a loss function inspired by image segmentation techniques. This method effectively reduces the domain gap between source and target domains and simultaneously captures fault information common to both simulated and real signals. The proposed method is validated through two case studies using different testbed datasets under various operating conditions. The results demonstrate the superior performance of our approach in handling domain shifts and different levels of partial labels, outperforming existing signal generation and domain adaptation methods. The proposed method also has a practical value in that the target bearing system can be diagnosed using physical knowledge even in the absence of fault signals that are difficult to obtain.
First detection of Bemisia tabaci (Hemiptera: Aleyrodidae) MED in Oklahoma and development of a high-resolution melting assay for MEAM1 and MED discrimination
Authors: Krause-Sakate Renate , Gomes Ruschel Rafaela , Ochoa-Corona Francisco , Andreason Sharon A , de Marchi Bruno Rossito , Ribeiro-Junior Marcos Roberto , Nascimento Daniele Maria , Trujillo Reese , Smith Hugh A , Hutton Samuel F , Wallace Sara 
Published: December 2024

Abstract
The sweetpotato whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), is a polyphagous pest recognized as composed of several cryptic or sibling species. The Middle East-Asia Minor 1 (MEAM1) and the Mediterranean (MED) putative species are invasive and destructive worldwide. The MEAM1 is established throughout the United States, while MED is documented in 27 states. This study determines the status of MED in Oklahoma and develops and validates a high-resolution melting (HRM) assay for discrimination of MEAM1 and MED. In August–October 2022, whiteflies were collected from different host plants in Stillwater, Oklahoma, and identified as species based on analysis of a diagnostic fragment of the mitochondrial cytochrome oxidase I (mtCOI) gene. MED was found in mixed infestations with MEAM1 on both sweetpotato in a greenhouse and cucumber in the field. Other cryptic species were not detected. Sequencing followed by phylogenetic analysis indicated that the MED specimens belonged to the Q2 mitotype. Additionally, the secondary endosymbionts in captured and progeny whiteflies were identified. For rapid discrimination of MEAM1 and MED species, an HRM assay using a single set of primer pairs targeting the mtCOI gene was developed. Species discrimination was tested in 2 laboratories using MEAM1 and MED Q2 mitotype genomic DNA, and a synthetic plasmid containing the MED Q1 mitotype mtCOI fragment. The HRM assay was validated to discriminate MEAM1 from MED Q1 and Q2 mitotypes. This is the first report of B. tabaci MED in Oklahoma and reinforces the need for continued monitoring of this insect species complex.
Hidden invaders: intraspecific cryptic invasion and hybridization of Dolichoderus thoracicus (Hymenoptera: Formicidae) in Taiwan
Authors: Hsu Feng-Chuan , Chen Joanne Tzu-Chia , Yamada Aiki , Hsiao Yun , Ho Chuan-Kai , Lin Chung-Chi , Oguri Emiko , Tseng Shu-Ping 
Published: December 2024

Abstract
Biological invasions pose substantial threats to global biodiversity, agriculture, and ecological stability. Among these, intraspecific cryptic invasions, characterized by the spread of nonnative genotypes within a species, present unique challenges for detection and management. Despite the well-documented influence of invasive ants on ecosystems, instances of intraspecific cryptic ant invasions have rarely been documented. This study focused on the black cocoa ant, Dolichoderus thoracicus (Smith 1860), which has been increasingly reported as a pest in Taiwan over the past decade. In this study, we utilized a genome-wide approach employing multiplexed inter-simple sequence repeats genotyping by sequencing to identify single nucleotide polymorphisms across the D. thoracicus populations, elucidating the variations in the genetic population structure of the species in Taiwan. Our findings confirmed the occurrence of intraspecific cryptic invasions, demonstrating the coexistence of native and nonnative lineages, along with potential hybridization events between them. This study underscores the critical role of comprehensive genetic analysis in uncovering the complex dynamics of species invasions.
Telling Meaningful Stories About Climate Change and Public Law
Authors: Fisher Elizabeth 
Published: December 2024

Abstract
Current scholarly discourse is dominated by stories about the role of strategic litigation as a mechanism for forcing public action in relation to climate change. While such stories are satisfying, they are not necessarily meaningful because they narrow the intellectual field of vision. By using an essay by Ursula Le Guin on narrative forms, I show that other more meaningful narratives are possible to tell. Narratives that encompass a bigger picture and, in so doing, draw attention to how public law is a resource for the institutional and reasoning capacity required for responding to the polycentric and multivalent nature of climate change. Such capacity does not provide a ‘solution’ to climate change but does underscore the need to foster legal and scholarly expertise and imagination in relation to climate change and public law.
Bolivia’s resistance to modification and commodification of seeds: challenges in aligning domestic situation with its international position
Authors: Ghimire Saurav , Van der Borght Kim , Frison Christine 
Published: December 2024

Abstract
Based on the concept of vivir bien, Bolivia has developed laws resisting modification and commodification of genetic resources. It has played an important role in international forums in promotion of these ideas and has been contributing to international law-making for farmers’ rights. From the perspective of farmers’ rights to seeds, this article examines Bolivia’s Plant Variety Protection (PVP) legislation and the cultivation of genetically modified soybean, the crop most frequently protected under PVP. This article argues that, while Bolivia has laws discouraging the modification and commodification of seeds and has been internationally resisting the same in favour of farmers’ rights, domestically the soybean farmers cannot exercise their minimally recognized rights of saving seeds under the PVP law. This article shows that mere exception to save seeds is not adequate to retain farmers’ ownership over the seeds, particularly in industrial farming. Therefore, the seed suppliers can exercise more rights than granted by law, ultimately securing the repeated purchase of seeds even from the smallholders. Besides, this article shows how the agro-industrial sector has influenced the government and has successfully accommodated their interest in the broader political objectives of food sovereignty and farmers’ rights. This article ultimately proposes that enabling smallholders soybean farmers to exercise their legally recognized right to save and repeatedly use their own seeds could be one of the means to protect them from the agricultural exclusion currently happening in the soybean sector in Bolivia.
Patent quality matters
Authors: Baldus Oliver 
Published: December 2024

Abstract
Patent quality can be determined reliably based on three distinct quality objectives, namely legal framework (legal quality), prior art (substantial quality) and market potential (economic quality). The legal quality of a patent is given by compliance with all legal requirements of the underlying legal framework. The substantial quality of a patent is given by the likelihood that a patent will not be invalidated based on prior art. The economic quality of a patent is given by the market potential of the subject matter protected by the patent.
Effects of elicitors on plant host selection by adult Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)
Authors: Butcher Alexander , Rondon Silvia I , Lee Jana , Paul Ryan 
Published: December 2024

Abstract
The Colorado Potato Beetle, Leptinotarsa decemlineata Say, is the principal defoliator of potato crops globally. It is well known for its propensity to rapidly develop resistance. Thus, new control options which are resilient to the pest’s resistance capabilities are a critical need. The use of chemical ecology in integrated pest management (IPM) programs has been proposed as a means to delay resistance. Elicitors are chemical growth regulators that activate plant defenses. These plant defenses provide numerous opportunities to integrate chemical ecology into IPM programs, including changes to a plants volatile profile. In this laboratory study, we provide evidence that elicitors which mimic jasmonic acid (JA) and salicylic acid (SA) can be used to attract or repel L. decemlineata respectively. Adult beetles are highly attracted to potato plants sprayed with the JA mimicking elicitor Blush 2X, while plants sprayed with SA mimicking elicitor, Actigard 50WG, appear to be repellent. Additionally, residency time on plants sprayed with Actigard 50WG was significantly shorter than with control plants. The potential use of elicitors within IPM program is discussed.
Association of plasma branched-chain amino acid levels with colorectal cancer risk in a nested case–control study
Authors: Hisada Izumi , Yamaji Taiki , Sawada Norie , Inoue Manami , Tsugane Shoichiro , Iwasaki Motoki ,   Japan Public Health Center-Based Prospective Study Group
Published: December 2024

Abstract

Background
Intake of branched-chain amino acids (BCAA) has been suggested to have a prophylactic effect against carcinogenesis in colorectal cancer (CRC). However, the possible effect of plasma BCAA concentration has not been fully evaluated.

Methods
We conducted a prospective case–control study within a cohort of four public health center areas for which blood sample and questionnaire data from a 5-year follow-up survey were available. We identified 360 newly diagnosed CRC cases during the follow-up period and selected two matched controls for each case. We estimated odds ratio (OR) and 95% confidence intervals (CI) for CRC using conditional logistic regression models adjusted for potential confounding factors.

Results
Increased plasma concentrations of BCAAs were not inversely associated with CRC risk after adjustment for potential confounders. Compared with the lowest quartile, ORs in the highest quartile of leucine, isoleucine, valine, and total BCAA were 0.74 (95% CI, 0.49–1.12), 0.85 (0.56–1.29), 0.75 (0.50–1.13), and 0.70 (0.47–1.05), respectively. After excluding cases diagnosed within the first 6 years of follow-up, total BCAA and leucine were significantly related to a decreased risk of CRC, with ORs in the highest quartile of total BCAA and leucine of 0.58 (0.35–0.96) and 0.56 (0.33–0.93), respectively.

Conclusions
We found no statistically significant inverse association between plasma BCAA concentrations and CRC risk in overall analyses, whereas on 6-year exclusion, total BCAA and leucine were associated with decreased CRC risk. Plasma BCAA concentrations may play a prophylactic role in colorectal carcinogenesis, and further investigation is warranted.
Patronage Networks, Personal Ties, and Political Selection: Evidence from a New Group of Subnational Officials in China
Authors: Si Ruichao , Xu Gang 
Published: December 2024

ABSTRACT
The current literature has paid much attention to the political selection of China’s subnational party secretaries and government executives (e.g., provincial governors). However, the party’s rule of collective leadership dictates that it is the Chinese Communist Party Provincial Standing Committee (PPSC), a group of officials with substantial power over local affairs, that collectively rules the province. How the members of PPSC are selected and promoted remains surprisingly understudied. This article fills this gap by examining how various types of personal connections with senior leaders can account for their career advancements. Empirical results show that they are more likely to be promoted if the provincial party secretary who once promoted them to the PPSC members later becomes a national leader. Further evidence indicates that this promotion-based patronage network fosters loyalty of junior officials to senior ones. Finally, we show that such patronage may also jeopardize the clients’ political careers during purges. (JEL D72, H77, P27)
Acceptability of an organ inventory for cancer screening across gender identity and intersex status
Authors: Moseson Heidi , Ragosta Sachiko , Gómez Anu Manchikanti , Corman Jae , Zussman Jay , Lesser-Lee Bori , Reese Sydney , Carter-Bolick India Rose , Obedin-Maliver Juno 
Published: December 2024

Abstract

Objectives
To evaluate the acceptability and performance of an organ inventory as an alternative to asking about gender and/or sex assigned at birth in cancer screening.

Methods
We fielded an online, self-administered survey to a convenience sample of English- or Spanish-speaking transgender and gender-diverse (TGD), intersex, and cisgender people (≥15 years) in the United States. The survey contained an organ inventory developed with community input and questions regarding acceptability. The primary outcome was organ inventory acceptability by the 4-item Acceptability of Intervention Measure (AIM). Additional outcomes included inter-method screening agreement between the organ inventory, gender, and sex assigned at birth.

Results
In 2022, 333 eligible individuals completed the survey: 44.4% cisgender, 34.2% TGD, and 14.1% intersex. Overall, participants rated the organ inventory as acceptable (median AIM score = 18/20, IQR: 16-20). Most of them found it easy to understand (73%) and comfortable to complete (65%). Cancer screening eligibility varied based on the method used; relying solely on gender or sex data would have missed some eligible participants that the organ inventory identified.

Conclusions
Using an organ inventory as an alternative to gender- or sex-based screening questions was acceptable and has implications for addressing cancer screening disparities.
Improving real-world evaluation of patient- and physician-reported tolerability: niraparib for recurrent ovarian cancer (NiQoLe)
Authors: Joly Florence , Bazan Fernando , Garbay Decoopman Delphine , Ouldbey Yaelle , Follana Philippe , Champeaux-Orange Élise , Legouffe Eric , Brachet Pierre-Emmanuel , Spaeth Dominique , Combe Pierre , Hardy-Bessard Anne-Claire , Selle Frédéric , Grenier Julien , Lebreton Coriolan , Derbel Olfa , Bonnet Elise , Fournel Pierre , Fernandez Diez Yolanda , Delecroix Valérie , Emambux Sheik , Alexandre Jérôme , Grellety Thomas , Mille Dominique , Orfeuvre Hubert , Favier Catherine , Le Roux Delphine , Mouret-Reynier Marie-Ange , Quesada Stanislas , Kurtz Jean-Emmanuel 
Published: December 2024

Abstract

Background
Maintenance niraparib at an individualized starting dose (ISD) is established in platinum-sensitive recurrent ovarian cancer (PSROC). However, patients’ perspectives on the burden of prolonged maintenance therapy have not been reported in prospective trials or routine practice.

Methods
In the real-life multicenter NiQoLe study, patients with PSROC received ISD maintenance niraparib. The primary objective was to describe physician-reported adverse events (AEs) leading to treatment modification during the first 3 months. Secondary endpoints included patient-reported outcomes (symptomatic AEs using PRO-CTCAE, self-reported fatigue and impact on daily activities/function using FACT-F) collected remotely weekly using a specifically designed electronic device.

Results
Most (80%) of 139 treated patients (median age 70 years) began niraparib at 200 mg/day. Median treatment duration was 5.7 (range 0.2–21.4) months. During the first 3 months, 86 patients (62%) required treatment modification (median 27 days to modification). Physician-reported grade ≥3 niraparib-related AEs occurred in 34 patients (24%); 68 patients (49%) had treatment modification for AEs, predominantly thrombocytopenia. The most frequent patient-reported AEs (PRO-CTCAE) were fatigue, insomnia, constipation, and dry mouth. Self-reported AEs were severe in 66% of patients. At baseline, 33% of patients reported severe fatigue (FACT-F), which generally persisted during niraparib. Physicians systematically underestimated major patient-reported symptoms.

Conclusions
In routine practice, dose modification was often required during the first 3 months despite individualized dosing. Physicians underestimated the burden of fatigue and symptomatic AEs. Digital self-reporting of AEs is feasible, provides patient-centered information complementing physician-reported AEs, and allows fuller appreciation of toxicity in real-world studies.

Clinical trial information
NCT03752216
Assessment of adherence to the Infectious Diseases Society of America guidelines for treating suspected meningitis in adults: a retrospective observational study
Authors: Mohialdin Dina , Abu-Farha Rana , ALkhawaldeh Rama , Al-Ashwal Fahmi Y , Abu Hammour Khawla 
Published: December 2024

Abstract

Objectives
This study aimed to assess physicians’ adherence to the Infectious Diseases Society of America (IDSA) guidelines in managing and treating adult patients (≥ 18 years old) admitted with suspected cases of meningitis and to investigate any associations between guideline adherence and hospital length of stay (LOS) as well as all-cause mortality among these patients.

Methods
This retrospective observational study was conducted at a tertiary care hospital in Jordan, focussing on adult patients admitted with suspected meningitis between 1 January 2019 and 30 September 2022. The study aimed to assess the appropriateness of antibiotic prescriptions before culture results according to IDSA guidelines and calculate the overall adherence rate. Additionally, the study observed hospital LOS and all-cause mortality among the enrolled patients.

Key findings
Of the enrolled adult patients (n = 118), 14.4% (n = 17) were diagnosed with bacterial meningitis. Notably, only five patients (4.2%) were treated appropriately, adhering entirely to the IDSA guidelines, whereas the remaining 95.8% (n = 113) showed various forms of non-adherence to these recommendations. The highest adherence to IDSA recommendations was observed in performing cerebrospinal fluid culture (100%), whereas the lowest adherence was noted in selecting appropriate doses and durations for the empiric antibiotics (n = 18, 26.5% and n = 21, 30.9%, respectively). No significant associations were found between adherence to IDSA treatment guidelines and hospital LOS (P = .100) or all-cause mortality (P = .332) among these patients.

Conclusion
This study revealed low overall adherence to IDSA guidelines among adult patients. Key areas for improvement in management include promptly selecting appropriate empiric antibiotics with correct dosing and duration to mitigate adverse effects and prevent bacterial resistance.
Decoding the power of saponins in ferroptosis regulation and disease intervention: a review
Authors: Ouyang Min , Wu Jianhua , Hu Xizhuo , Liu Changfu , Zhou Dan 
Published: December 2024

Abstract

Objectives
This review endeavors to elucidate the complex interplay underlying diseases associated with ferroptosis and to delineate the multifaceted mechanisms by which triterpenoid and steroidal saponins modulate this form of cell death.

Methods
A meticulous examination of the literature was undertaken, drawing from an array of databases including Web of Science, PubMed, and Wiley Library, with a focus on the keywords “ferroptosis,” “saponin,” “cancer,” “inflammation,” “natural products,” and “signaling pathways.”

Key findings
Ferroptosis represents a distinctive mode of cell death that holds considerable promise for the development of innovative therapeutic strategies targeting a wide range of diseases, especially cancer and inflammatory disorders. This review reveals the nuanced interactions between saponins and critical signaling pathways, including system Xc−-GSH-GPX4, Nrf2, p53, and mTOR. These interactions highlight the dual capacity of saponins to modulate ferroptosis, thereby offering fresh perspectives for therapeutic intervention.

Conclusions
The insights garnered from this review significantly advance our comprehension of the dynamic relationship between saponins and ferroptosis. By shedding light on these mechanisms, this work sets the stage for leveraging these insights in the creation of pioneering approaches to disease treatment, marking a significant stride in the evolution of therapeutic modalities.
Robustness, model checking, and hierarchical models
Authors: Cabral Rafael , Bolin David , Rue Håvard 
Published: December 2024

Abstract
Model checking is essential to evaluate the adequacy of statistical models and the validity of inferences drawn from them. Particularly, hierarchical models such as latent Gaussian models (LGMs) pose unique challenges as it is difficult to check assumptions on the latent parameters. Diagnostic statistics are often used to quantify the degree to which a model fit deviates from the observed data. We construct diagnostic statistics by (a) defining an alternative model with relaxed assumptions and (b) deriving the diagnostic statistic most sensitive to discrepancies induced by this alternative model. We also promote a workflow for model criticism that combines model checking with subsequent robustness analysis. As a result, we obtain a general recipe to check assumptions in hierarchical models and the impact of these assumptions on the results. We demonstrate the ideas by assessing the latent Gaussianity assumption, a crucial but often overlooked assumption in LGMs. We illustrate the methods via examples utilizing Stan and provide functions for easy usage of the methods for general models fitted through R-INLA.