bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravenous thrombolysis for large vessel or distal occlusions presenting with mild stroke severity
Authors: Tsivgoulis G. , Goyal N. , Katsanos A. H. , Malhotra K. , Ishfaq M. F. , Pandhi A. , Frohler M. T. , Spiotta A. M. , Anadani M. , Psychogios M. , Maus V. , Siddiqui A. , Waqas M. , Schellinger P. D. , Groen M. , Krogias C. , Richter D. , Saqqur M. , Garcia‐Bermejo P. , Mokin M. , Leker R. , Cohen J. E. , Magoufis G. , Psychogios K. , Lioutas V. A. , Van Nostrand M. , Sharma V. K. , Paciaroni M. , Rentzos A. , Shoirah H. , Mocco J. , Nickele C. , Mitsias P. D. , Inoa V. , Hoit D. , Elijovich L. , Arthur A. S. , Alexandrov A. V. 
Published: March 2020

Background and purposeWe investigated the effectiveness of intravenous thrombolysis (IVT) in acute ischaemic stroke (AIS) patients with large vessel or distal occlusions and mild neurological deficits, defined as National Institutes of Health Stroke Scale scores < 6 points.MethodsThe primary efficacy outcome was 3‐month functional independence (FI) [modified Rankin Scale (mRS) scores 0–2] that was compared between patients with and without IVT treatment. Other efficacy outcomes of interest included 3‐month favorable functional outcome (mRS scores 0–1) and mRS score distribution at discharge and at 3 months. The safety outcomes comprised all‐cause 3‐month mortality, symptomatic intracranial hemorrhage (ICH), asymptomatic ICH and severe systemic bleeding.ResultsWe evaluated 336 AIS patients with large vessel or distal occlusions and mild stroke severity (mean age 63 ± 15 years, 45% women). Patients treated with IVT (n = 162) had higher FI (85.6% vs. 74.8%, P = 0.027) with lower mRS scores at hospital discharge (P = 0.034) compared with the remaining patients. No differences were detected in any of the safety outcomes including symptomatic ICH, asymptomatic ICH, severe systemic bleeding and 3‐month mortality. IVT was associated with higher likelihood of 3‐month FI [odds ratio (OR), 2.19; 95% confidence intervals (CI), 1.09–4.42], 3‐month favorable functional outcome (OR, 1.99; 95% CI, 1.10–3.57), functional improvement at discharge [common OR (per 1‐point decrease in mRS score), 2.94; 95% CI, 1.67–5.26)] and at 3 months (common OR, 1.72; 95% CI, 1.06–2.86) on multivariable logistic regression models adjusting for potential confounders, including mechanical thrombectomy.ConclusionsIntravenous thrombolysis is independently associated with higher odds of improved discharge and 3‐month functional outcomes in AIS patients with large vessel or distal occlusions and mild stroke severity. IVT appears not to increase the risk of systemic or symptomatic intracranial bleeding.
Improving sustainable yield estimates for tropical reef fisheries
Authors: McClanahan Timothy R. , Azali Maxwell Kodia 
Published: March 2020

AbstractFishing sustainably is a fundamental problem in tropical regions where diverse fisheries and scarce fisheries information challenges efforts to make reliable estimates and associated policies. To improve evaluations and decisions, we compared the predictions of six surplus production models calibrated using various permutations of fisheries‐dependent data with a benchmark model. The benchmark model was built from fisheries‐independent estimates of r and K, tested against rates of change in Kenyan reef fisheries and found to be accurate. Comparisons with the benchmark model were made with fisheries‐dependent equilibrium and non‐equilibrium models, fixing or not fixing r and K, pooled versus site averaged solutions, and rising, falling, and pooled fishing effort over time. Evaluations indicate high variability in MMSY predictions and notable overestimates of MMSY (~75%) and effort (~210%) for Fox and Schaefer equilibrium models. Non‐equilibrium models had high failure rates (~25%) but successful fits performed better and indicated smaller overestimates (16%) for site‐level evaluations. The Pella–Tomlinson model was most accurate (MMSY = 5.6 ± 0.60 (SD) tonnes/km2/year) and best‐fit r‐K relationships also aligned well with ecoregional data on K and short‐term yields. Future efforts are advised to pool site data, use conservative recruitment values (z = 0.8), and collect data across times of both rising and falling effort. Recommended methods and subsequent adjustments of the benchmark model should improve local and ecoregional scale MMSYs. The benchmark model was calibrated to estimate MMSY in fished seascapes, but to conserve species with slower life histories, we suggest modifications to limit MMSYs to between 1.8 and 3.2 tonnes/km2/year.
Monitoring tropical forests under a functional perspective with satellite‐based vegetation optical depth
Authors: Vaglio Laurin Gaia , Vittucci Cristina , Tramontana Gianluca , Ferrazzoli Paolo , Guerriero Leila , Papale Dario 
Published: March 2020

AbstractMonitoring ecosystem functions in forests is a priority in a climate change scenario, as climate‐induced events may initially alter the functions more than slow‐changing attributes, such as biomass. The ecosystem functional properties (EFPs) are quantities that characterize key ecosystem processes. They can be derived by point observations of gas and energy exchanges between the ecosystems and the atmosphere that are collected globally at FLUXNET flux tower sites and upscaled at ecosystem level. The properties here considered describe the ability of ecosystems to optimize the use of resources for carbon uptake. They represent functional forest information, are dependent on environmental drivers, linked to leaf traits and forest structure, and influenced by climate change effects. The ability of vegetation optical depth (VOD) to provide forest functional information is investigated using 2011–2014 satellite data collected by the Soil Moisture and Ocean Salinity mission and using the EFPs as reference dataset. Tropical forests in Africa and South America were analyzed, also according to ecological homogeneous units. VOD jointly with water deficit information explained 93% and 87% of the yearly variability in both flux upscaled maximum gross primary productivity and light use efficiency functional properties, in Africa and South America forests respectively. Maps of the retrieved properties evidenced changes in forest functional responses linked to anomalous climate‐induced events during the study period. The findings indicate that VOD can support the flux upscaling process in the tropical range, affected by high uncertainty, and the detection of forest anomalous functional responses. Preliminary temporal analysis of VOD and EFP signals showed fine‐grained variability in periodicity, in signal dephasing, and in the strength of the relationships. In selected drier forest types, these satellite data could also support the monitoring of functional dynamics.
Hybrid organic‐inorganic Cu(II) iminoisonicotine@TiO2@Fe3O4 heterostructure as efficient catalyst for cross‐couplings
Authors: Adam Mohamed Shaker S. , Ullah Farman , Makhlouf Mohamed M. 
Published: March 2020

AbstractTwo novel mononuclear copper (II) complex catalysts were synthesized from a new tridentate iminoisonicotine ligand (HL) by coordination with Cu(II) ion, with (CuL@TiO2@Fe3O4) and without (CuL) immobilization on TiO2‐coated nanoparticles of Fe3O4. The ester moiety on the back of the ligand was utilized for immobilization on nanoparticles of Fe3O4. Both ligand and CuL complex were fully characterized by using alternative spectral techniques (nuclear magnetic resonance, infrared, ultraviolet‐visible and mass spectroscopy, and elemental analyses). Different analytical techniques were used to identify the structural feature and morphology of the immobilized copper catalyst (CuL@TiO2@Fe3O4) shell‐shell‐core system. The structural analysis revealed that the catalyst system is composed of both agglomerated nanospheres and deformed nanorods. Both copper catalysts, immobilized CuL@TiO2@Fe3O4 and un‐immobilized CuL were studied in heterogeneous and homogeneous catalysis, respectively, for Suzuki‐Miyaura (C–C) and Buchwald‐Hartwig (C–N) cross‐coupling reactions of various heteroaryl halides. Both catalysts showed good catalytic potential under the controlled optimal reaction conditions. In contrast to the homogeneous catalyst (CuL), the heterogeneous catalyst (CuL@TiO2@Fe3O4) showed slightly better catalytic performance. The characteristic obtains supported the catalytic potential of the current samples. Reusability/recycling of both catalysts was also investigated in C–C cross‐coupling reactions. It was found that the homogeneous catalyst (CuL) could be only recycled up to three times, whereas the heterogeneous one (CuL@TiO2@Fe3O4) could be reused up to seven times with good efficiency.
Characterization of Aquimarina hainanensis isolated from diseased mud crab Scylla serrata larvae in a hatchery
Authors: Midorikawa Yuki , Shimizu Tomohito , Sanda Tetsuya , Hamasaki Katsuyuki , Dan Shigeki , Lal Mohammad Tamrin Bin Mohamad , Kato Goshi , Sano Motohiko 
Published: March 2020

AbstractMass mortality due to necrosis signs occurred in hatchery‐reared zoea stage larvae of the mud crab Scylla serrata in Okinawa, Japan, and a causative bacterium was isolated. In this study, we identified and characterized the bacterium by genome analysis, biochemical properties and pathogenicity. The bacterium was a Gram‐negative, non‐motile, long rod, forming yellow colonies on a marine agar plate. It grew at 20–33°C (not at 37°C) and degraded chitin and gelatin. Phylogenetic analysis of the 16S rRNA gene sequence identified the bacterium as Aquimarina hainanensis. Genome sequence data obtained from Illumina MiSeq generated 29 contigs with 3.56 Mbp in total length and a G + C content of 32.5%. The predicted 16 chitinase genes, as putative virulence factors, had certain homologies with those of genus Aquimarina. Experimental infection with the bacterium conducted on larvae of four crustacean species, brine shrimp Artemia franciscana, freshwater shrimp Caridina multidentata, swimming crab Portunus trituberculatus and mud crab S. serrata, revealed that this bacterium was highly virulent to these species. The present study suggests that the bacterium caused mass mortality in mud crab seed production was A. hainanensis and can be widely pathogenic to crustaceans.
Experimental energy‐exergy performance and kinetics analyses of compact dual‐mode heat pump drying of food chips
Authors: Singh Akhilesh , Sarkar Jahar , Sahoo Rashmi Rekha 
Published: March 2020

AbstractBatch‐type heat pump dryer operating in both closed and open‐cycle modes with improved tray design is developed to investigate the energetic and exergetic performances, and drying kinetics of banana and potato chips. Effects of drying time on various performances and drying kinetic parameters are presented. Coefficient of performance of heat pump as well as whole system is higher for open‐cycle mode. Higher specific moisture extraction rate is obtained as 1.248 kg/kWh for closed cycle drying of banana chips. Drying efficiency is also found higher for the closed cycle. The specific energy consumption is lower (0.8 kWh/kg) in closed system drying for banana. Total exergy destruction is found higher for the closed system. Mass transfer coefficient and moisture diffusivity are better for the closed system. On the basis of studied performance parameters, the closed system drying is found better than the open system drying in humid and hot ambient conditions.Practical ApplicationsThis study develops a heat pump dryer (HPD) operated with both closed and open‐cycle modes, which can control the air recirculation to provide optimum main drying parameters to get the best drying performance. The novelty of this study is twofold: controlling of air recirculation to get optimum condition and improved design of trays in drying cabinet for best possible air distribution to get maximum SMER (the obtained SMER value is more than the reported SMER values of other developed prototypes available in the literature). The results have been evaluated to provide better information about the benefits of varying air recirculation in the HPD system. Drying kinetic has also been determined experimentally, which will be helpful for modeling potato and banana drying. This study will help to develop commercial HPD operated in closed/open mode depending on environmental conditions for food chips drying.
A UNIFIED PRESENTATION OF COMPETITION ANALYSIS IN TWO‐SIDED MARKETS
Authors: Pontual Ribeiro Eduardo , Golovanova Svetlana 
Published: March 2020

AbstractThe goal of this paper is to present quantitative tools to manage competition policy analysis in two‐sided platforms, based on a common framework for transaction and non‐transaction platforms. We explore tools for relevant market definition [Critical Loss Analysis and a small but significant non‐transitory increase in price (SSNIP) test], unilateral effects indicators [Upward Pricing Pressure (UPP) and Gross Upward Pricing Pressure Index (GUPPI)] and tests for exclusionary practices. We review dispersed results in the literature and fill the gaps where appropriate. We highlight the required changes from the usual one‐sided market framework and tools. While discussions of antitrust tools can be found in specialized forums devoted to advances in competition policy analysis, we organize the material in an integrated framework.
Relationship‐Based Selective Participation of Secondary Respondents in a German Multi‐Actor Panel Study
Authors: Hünteler Bettina , Wetzel Martin 
Published: March 2020

AbstractObjectiveThis study investigates the extent to which participation of secondary respondents (SRs), here mothers, in a multi‐actor study is cross‐sectionally and longitudinally biased regarding relationship characteristics with the primary respondent (PR) of the same study.BackgroundFamily research emphasizes the importance of analyzing family relations over time and from the perspectives of several family members. Following the leverage‐salience theory, selective (re‐)participation of PRs and SRs might bias a sample toward certain relationship characteristics, in particular over
time.MethodFor 8,579 PRs of the German Family Panel Study (
www.pairfam.de/en/), it is analyzed whether or not their mothers as SRs participated in Wave 2 and 4. A latent class analysis identifies relationship types based on the PR's evaluation of “intergenerational solidarity and conflict”. Their influence on the respondents' probability of (re‐)participation is examined using simultaneously estimated linear probability models.ResultsEach of the four identified relationship types exhibited a particular but constant pattern of SR survey participation. This resulted in an overrepresentation of structurally and functionally closer relationships at each observation. This bias is mostly based on the PR's selectively given consent to interview her/his SR and to a smaller extent on the selective (re‐)participation of the SR or
PR themselves.ConclusionSR data are selective, but the degree of selectivity remains rather stable over time. We discuss these findings with respect to both data users and future data collectors.
The Strategic Practice of “Fiesta” in a Latino Protestant Church: Religious Racialization and the Performance of Ethnic Identity
Authors: Ramos Aida I. , Martí Gerardo , Mulder Mark T. 
Published: March 2020

AbstractFounded and led by a U.S.‐born white pastor, Amor Poderoso is a nondenominational, evangelical megachurch in El Paso, Texas, almost entirely composed of Mexican‐Americans, recent Mexican immigrants, and current Mexican citizens. Ethnographic fieldwork from 2014 to 2017, supplemented with interviews with pastors, worship leaders, and attendees, reveal that much of congregational life orients around intentionally showcasing “Mexican” culture through sounds, images, and artifacts that appropriate an array of idealized ethnic references (e.g., food, dress, mannerisms, clichés) from Northern Mexico. Ongoing ethnic displays do not originate spontaneously or impromptu from membership but rather serve as a form of tactical authenticity derived from U.S. racial schemas mobilized by congregational leaders as a distinctive religious resource. Weekly worship services featuring dialect‐inflected Spanish preaching and singing project ethnic signals that elicit connections to both a common ancestral heritage and a common religious identity. In short, church leaders at this southern border Latino church deliberately deploy sounds, images, and artifacts to assert racialized performances of being “Mexican” for distinctly religious purposes, especially evangelization. In the process, the distinctive practices of religious racialization effectively structure church members’ ethnic and religious identities around racial tropes to buttress a cogent corporate identity for enacting institutionalized evangelical narratives and legitimating charismatic authority.
Learning in the workplace: Use of informal feedback cues in doctor‐patient communication
Authors: Sehlbach Carolin , Teunissen Pim W. , Driessen Erik W. , Mitchell Sharon , Rohde Gernot G. U. , Smeenk Frank W. J. M. , Govaerts Marjan J. B. 
Published: March 2020

AbstractObjectivesWe expect physicians to be lifelong learners. Participation in clinical practice is an important potential source of that learning. To support physicians in this process, a better understanding of how they learn in clinical practice is necessary. This study investigates how physicians recognise and use informal feedback from interactions with patients in outpatient settings as learning cues to adjust their communication behaviours in daily practice.MethodsTo understand physicians’ use of informal feedback, we combined non‐participant observations with semi‐structured interviews. We enrolled 10 respiratory physicians and observed 100 physician‐patient interactions at two teaching hospitals in the Netherlands. Data collection and analysis were performed iteratively according to the principles of constructivist grounded theory.ResultsFollowing stages of open, axial and selective coding, we were able to conceptualise how physicians use cues to reflect on and adjust their communication. In addition to vast variations within and across patient encounters, we observed recurring adjustments in physicians’ communication behaviours in response to specific informal feedback cues. Physicians recognised and used these cues to self‐monitor communication performance. They had established ‘communication repertoires’ based on multiple patient interactions, which many saw as learning opportunities contributing to the development of expertise. Our findings, however, show differences in physicians’ individual levels of sensitivity in recognising and using learning opportunities in daily practice, which were further influenced by contextual, personal and interpersonal factors. Whereas some described themselves as having little inclination to change, others used critical incidents to fine‐tune their communication repertoires, and yet others constantly reshaped them, seeking learning opportunities in their daily work.ConclusionsThere is large variation in how physicians use learning cues from daily practice. To enhance learning in and from daily practice, we propose turning workplace learning into a collaborative effort with the aim of increasing awareness and the use of informal performance‐relevant feedback.
A case of area postrema syndrome associated with sick sinus syndrome in an elderly patient with neuromyelitis optica spectrum disorder: Case report
Authors: Komaki Ryouhei , Chihara Norio , Hara Atsushi , Fujisawa Satoshi , Muramae Naokazu , Nakasone Kazutaka , Ueda Takehiro , Sekiguchi Kenji , Matsumoto Riki 
Published: March 2020

AbstractWe described an elderly man with neuromyelitis optica spectrum disorder (NMOSD) causing sick sinus syndrome (SSS) following intractable hiccups caused by area postrema syndrome (APS). He had multiple cardiovascular risk factors including coronary angina, diabetes mellitus, hyperlipidemia, and smoking history. His SSS resolved following the disappearance of the hiccups. Clinicians should be aware that severe bradyarrhythmia could be associated with APS, especially in NMOSD patients.
An update on the implications of cyclin D1 in melanomas
Authors: González‐Ruiz Lucia , González‐Moles Miguel Ángel , González‐Ruiz Isabel , Ruiz‐Ávila Isabel , Ayén Ángela , Ramos‐García Pablo 
Published: March 2020

AbstractCyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation. Despite the demonstrated importance of CCND1/cyclin D1 as a central oncogene in several types of human tumors, its knowledge in melanoma is still limited. This review examines data published on upregulation of the CCND1 gene and cyclin D1 protein in the melanoma setting, focusing on the pathways and molecular mechanisms involved in the activation of the gene and on the clinical and therapeutic implications.
Correlation of testicular artery Doppler velocimetry with kinetics and morphologic characteristics of epididymal sperm in dogs
Authors: Trautwein Luiz Guilherme Corsi , Souza Anne Kemmer , Cardoso Guilherme Schiess , da Costa Flaiban Karina Keller Marques , de Oliveira Dearo Antonio Cezar , Martins Maria Isabel Mello 
Published: March 2020

AbstractSperm quality can be affected by a reduction in testicular blood flow, which can be measured by Doppler ultrasonography. The aim of this study was to correlate the Doppler velocimetry of the testicular artery with kinetics of the epididymal spermatozoa in dogs. Twenty‐two dogs (44 testicles) were evaluated by Doppler ultrasonography in five regions of the testicular artery before orchiectomy. Spermatozoa were recovered by the epididymal tail compression technique and analysed for kinetics on a computer‐assisted semen analysis (CASA system). Morphology (modified Karras) and sperm membrane integrity were analysed by eosin–nigrosine staining. Data were analysed by Pearson's correlation test (p < .01). The mean total motility was 69.0% ± 17.7, progressive motility was 43.7% ± 14.7, average path velocity (VAP) was 127.0 µm/s ± 20.7, curvilinear velocity (VCL) was 221.0 µm/s ± 31.1, and sperm velocity index (SVI) was 389.9 ± 56.1. There were positive correlations between the peak systolic velocity (PSV) in the proximal supratesticular region with the SVI (r = .529), VCL (r = .555) and VAP (r = .473), and a negative correlation with the percentage of slow spermatozoa (r = −.463). The results suggest that the testicular artery blood flow velocity can positively affect the speed of spermatozoa movement. For the first time, we have correlated sperm kinetics with the Doppler evaluation of the testicular artery in dogs.