bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hazardous alcohol consumption among older adults: A comprehensive and multi-national analysis of predictive factors in 13,351 individuals
Authors: Listabarth Stephan , Vyssoki Benjamin , Waldhoer Thomas , Gmeiner Andrea , Vyssoki Sandra , Wippel Andreas , Blüml Victor , Gruber Maria , König Daniel 
Published: December 2020

Abstract

Background
Older adults exhibit heightened vulnerability for alcohol-related health impairments. Increases in the proportion of older adults within the European Union’s total population and prevalence rates of alcohol use disorders in this age group are being observed. This large scale international study was conducted to identify those older adults with an increased risk to engage in hazardous drinking behaviour.

Methods
Socio-demographic, socio-economic, personality characteristics (Big Five Inventory, BFI-10), and alcohol consumption patterns of 13,351 individuals from 12 different European countries, collected by the Survey of Health, Aging, and Retirement in Europe, were analyzed using regression models.

Results
Age, nationality, years of education, as well as personality traits, were significantly associated with alcohol intake. For males, extraversion predicted increased alcohol intake (RR = 1.11, CI = 1.07–1.16), whereas conscientiousness (RR = 0.93, CI = 0.89–0.97), and agreeableness (RR = 0.94, CI = 0.90–0.99), were associated with a reduction. For females, openness to new experiences (RR = 1.11, CI = 1.04–1.18) predicted increased alcohol intake. Concerning excessive drinking, personality traits, nationality, and age-predicted consumption patterns for both sexes: Extraversion was identified as a risk factor for excessive drinking (OR = 1.15; CI = 1.09–1.21), whereas conscientiousness was identified as a protective factor (OR = 0.87; CI = 0.823–0.93).

Conclusion
Hazardous alcohol consumption in the elderly was associated with specific personality characteristics. Preventative measures, crucial in reducing deleterious health consequences, should focus on translating the knowledge of the association of certain personality traits and alcohol consumption into improved prevention and treatment.
ПОЛИСЕМИЯ, КОНТЕКСТ И ТРАНСЛЯЦИЯ СМЫСЛОВ
Authors: Vorkachev Sergey Grigorievich , Vorkacheva Elena Aleksandrovna 
Published: December 2020

Цель. Исследование явления полисемии и контекста как средства идентификации смысла речевого употребления многозначных единиц языка.Материалы и методы. Анализ представлений о многозначности и контексте в работах по лингвистике и обобщение результатов опубликованных авторами статьи работ по лексической семантике и лингвоконцептологии.Результаты. Устанавливается, что контекст обладает различной степенью «разрешающей способности» и может быть «сильным» – достаточным для однозначного опознания какого-то одного из значений многозначной единицы и «слабым» – недостаточным для такого опознания. «Асимметричный дуализм языкового знака» реализуется в речи в «сильных» контекстах как синкретизм, а в «слабых» контекстах – как амфиболия. Языковая полисемия единиц языка обычно снимается в контекстах их речевого употребления, однако иногда эта многозначность сохраняется, что свидетельствует о небрежности отправителя речи либо о его стремлении намеренно ввести в заблуждение своего партнера по коммуникации. Понятие разрешающей силы контекста успешно используется для диагностирования «сильных» и «слабых» контекстов речевого употребления как лексических, так и грамматических единиц в испанском, английском и русском языках.Заключение. В модели перевода, основанной на теории закономерных соответствий, выбор вариантных соответствий определяется речевым контекстом и в значительной мере зависит от лингвокультурной компетенции переводчика.
Vortex random fiber laser with controllable orbital angular momentum mode
Authors: Ma Xiaoya , Ye Jun , Zhang Yang , Xu Jiangming , Wu Jian , Yao Tianfu , Leng Jinyong , Zhou Pu 
Published: December 2020

In this paper, we propose and experimentally demonstrate a vortex random fiber laser (RFL) with a controllable orbital angular momentum (OAM) mode. The topological charge of the vortex RFL can range from

−
50

t
o

50

with nearly watt-level output power. A triangular toroidal interferometer is constructed to verify the spiral phase structure of the generated vortex random laser with a special coherence property. Vortex RFLs with fractional topological charge are also performed in this work. As the first demonstration of a vortex RFL with a controllable OAM mode (to the best of our knowledge), this work may not only offer a valuable reference on temporal modulation of a vortex beam and optical field control of an RFL but also provide a potential vortex laser source for applications in imaging, sensing, and communication.
Ascertaining breast cancer patient experiences through a journey map: A qualitative study protocol
Authors: Ciria-Suarez Laura , Jiménez-Fonseca Paula , Palacín-Lois María , Antoñanzas-Basa Mónica , Férnández-Montes Ana , Manzano-Fernández Aranzazu , Castelo Beatriz , Asensio-Martínez Elena , Hernando-Polo Susana , Calderon Caterina 
Published: December 2020

Background
The current cancer care system must be improved if we are to have in-depth knowledge about breast cancer patients’ experiences throughout all the stages of their disease.

Aim
This study seeks to describe breast cancer patients’ experience over the course of the various stages of illness by means of a journey model.

Methods
This is a qualitative descriptive study. Individual, semi-structured interviews will be administered to women with breast cancer and breast cancer survivors. Patients will be recruited from nine large hospitals in Spain and intentional sampling will be used. Data will be collected by means of a semi-structured interview that was elaborated with the help of medical oncologists, nurses, and psycho-oncologists. Data will be processed adopting a thematic analysis approach.

Discussion
The outcomes of this study will afford new insights into breast cancer patients’ experiences, providing guidance to improve the care given to these individuals. This protocol aims to describe the journey of patients with breast cancer through the healthcare system to establish baseline data that will serve as the basis for the development and implementation of a patient-centered, evidence-based clinical pathway.
Análise da qualidade da água subterrânea
Authors: Laureano Josilena de Jesus , Mendonça Alan Gomes , Lopes Daíse da Silva , Sousa Lindolaine Machado de , Lima Tiago de Oliveira , Rosa Ana Lúcia Denardin da , Bastos Wanderley Rodrigues , Nascimento Elisabete Lourdes do 
Published: December 2020

Este trabalho teve por objetivo avaliar a qualidade da água subterrânea do aquífero livre na microbacia do igarapé Nazaré (Ji-Paraná-RO), por meio de análises físico-químicas e microbiológicas. Foram realizadas 4 coletas de amostras de água em 15 poços rasos nos meses de (março, junho, setembro e dezembro de 2019). Os parâmetros condutividade elétrica, temperatura e o pH foram determinadas in loco por meio de sonda multiparâmetros. A turbidez e os sólidos totais dissolvidos foram determinados no laboratório com sondas especificas. O oxigênio dissolvido foi determinado pelo método titulométrico, a alcalinidade total foi obtida por titulação potenciométrica. As análises dos nutrientes foram realizadas por métodos espectrofotométricos, e as análises microbiológicas realizadas conforme o método de membrana filtrante em meio cromogênico. De acordo com os Valores Máximos Permitidos estabelecidos pela Portaria de Consolidação n° 5/2017 do Ministério da Saúde e com a Resolução do Conselho Nacional do Meio Ambiente CONAMA n° 396/2008, estiveram em desconformidade com tais legislações os coliformes totais, Escherichia coli, pH, turbidez e o nitrato. A análise de componentes principais não evidenciou diferença entre os períodos avaliados. Os resultados indicaram que a água dos poços encontra-se fora do padrão de potabilidade permitido para o consumo, podendo apresentar riscos à saúde humana.
Culture Club: Experiences of running a journal club for continuing professional development in higher education
Authors: Turner Jim Christopher , Mason Amanda , Harrison Roger , Varga-Atkins Tunde 
Published: December 2020

This article discusses the experiences of a journal club established to enable staff from different higher education (HE) institutions and roles to develop their knowledge and understanding around a shared interest in the areas of internationalisation and educational technology. Journal clubs have been used, mainly within the field of medicine and healthcare, to facilitate group learning. The club enabled the group to navigate a complex terrain of literature, develop a focus for reading and identifying a potential area for research and collaboration. Members of the journal club experienced several benefits from participation which are discussed together with the challenges of sustaining engagement over time. The article concludes with highlighting ways in which journal clubs can provide a fruitful form of continuing professional development in higher education, particularly in complex subject areas that traverse numerous roles and domains and makes recommendations for those considering establishing a journal club for similar purposes.
Design, Fabrication, and Performance Analysis of Intelligent Mesoscale Capacitive Accelerometer for Vibration Measurement
Authors: Gomathi K. , Sakthivel R. , Joseph John Marshal S. , Pratheep V. G. 
Published: December 2020

Abstract
This paper portrays an accelerometer as a motion sensor used to measure acceleration, vibration, and tilt angles which plays a vital role in the constructional field, inertial measurements, automotive safety system, biomedical, and yet other safety applications. A small packaged accelerometer can be made larger in size by acquiring an external power source or battery. The designed micro-accelerometer is fabricated using clean room technology, which is not quite cost effective, and even the silicon base is replaced by steel because of steel’s high yield strength and low cost to fabricate a mesoscale accelerometer. Design parameters are optimized by a Decision Tree Algorithm where the optimized dimensions are used to model the mesoscale accelerometer in INTELLISUITE 8.6 software. A Wire-cut discharger is used for the fabrication of mechanical elements of an accelerometer with a spring steel foil to reduce fabrication cost. Finally, the fabricated accelerometer with a mesoscale was made to undergo experimentation with a hammer drill and compared with simulation results to evaluate its performance in a harsh construction environment. 0.576 (μm/g) of mechanical sensitivity and 0.629 (pF/g) of electrical sensitivity is achieved.
Does meniscal release confer similar clinical benefits to meniscal tear treatment when compared to meniscectomy?
Authors: Garland Ben 
Published: December 2020

PICO question
In adult dogs with naturally occurring medial meniscal tears concurrent to cranial cruciate ligament disease does meniscal release confer the same benefits in lameness resolution as meniscectomy?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
A single prospective cross-sectional study was reviewed, that fulfilled the criteria
Strength of evidence
None
Outcomes reported
Meniscal release, meniscectomy (partial, hemi- or complete), or the two combined performed for concurrent medial meniscal pathology at time of surgery for naturally occurring cranial cruciate ligament (CCL) rupture resulted in an acceptable long-term outcome. Difference in outcome between the techniques was not reported
Conclusion
There is no evidence that meniscal release provides an equal or superior treatment option for medial meniscal injury treated at the time of surgery for CCL rupture when compared to meniscectomy. The study critically reviewed performed meniscal release via radial transection through the meniscotibial ligament, and therefore does not represent mid-body abaxial radial release. Neither is this summary appropriate for considering prophylactic meniscal release of the normal meniscus. In addition, the surgical treatments for cranial cruciate ligament rupture were either ‘Tightrope’ or tibial plateau levelling osteotomy (TPLO) procedures. Further studies are required to compare clinical outcome between meniscal release or meniscectomy for treatment of concurrent meniscal tears

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
PENERAPAN ANALISIS FAKTOR REDUCTION DALAM DETERMINASI IMPLEMENTASI STANDAR AKUNTANSI KEUANGAN ENTITAS MIKRO KECIL DAN MENENGAH (SAK EMKM)
Authors: Hidayanti Anna Apriana , Agus Khazin Fauzi  , Baiq Desthania Prathama  
Published: December 2020

The current research was carried out to investigate the correlation of educational background, perceived usefulness, perceived ease of use, socialization and quality of human resources with (SAK-EMKM) Implementation by reducing variables to several factors using the factor analysis method. Data collection in this study with a questionnaire given to the owner of the by Micro, Small and Medium Enterprises (MSMB) in Mataram city and 40 UMKM samples were obtained using purposive sampling technique, factor analysis aim to reduce the dimensionality of a set of data and clearly designed with the objective to identify certain unobservable factors from the observed variables. The results of this study were formed into two factors: 1st factor is these factors are termed the perception of the owner of the by Micro, Small and Medium Enterprises (MSMB) formed from the perception and variables using SAK EMKM perception then against SAK-EMKM implementation has a positive effect. 2nd factor is these factor was human resources factors formed from the educational background variable and the quality of human resources variable and against SAK-EMKM implementation has positive correlation.
Literatura e leitura literária: agentes transformadores de vidas em uma comunidade atendida pelo Centro de Referência de Assistência Social
Authors: Cardoso de Faria e Custódio Raquel , Pereira Villela Ana Paula 
Published: December 2020

O presente artigo apresenta os resultados da ação extensionista “Círculos de Leitura e Centro de Referência de Assistência Social– transformação e literatura”, realizada em 2019 e promovida pelo Instituto Federal Catarinense – Campus São Bento do Sul com o intuito de colocar em prática uma das principais missões que o Instituto Federal Catarinense possui, que é promover a cultura, em nosso caso o gosto pela literatura, dentro da comunidade em que está inserido. O projeto atendeu jovens entre 10 e 13 anos, assistidos pelo Centro de Referência de Assistência Social, em encontros quinzenais visando estimular a leitura literária. Mesmo possuindo enfoque prático, toda a ação foi realizada a partir de embasamentos teóricos que estimulassem a comunicação e novas estratégias de leitura, assim como auxiliassem as crianças e os adolescentes a lançarem mão da literatura como uma possibilidade de autoconhecimento. A partir das estratégias aplicadas para desenvolver o hábito de leitura literária, observou-se, no decorrer dos encontros, um envolvimento maior dos participantes e um aprimoramento nas leituras e nas interpretações, além da ampliação da visão e do conhecimento de mundo, manifestados nas atividades propostas.
Cardiac complications and pertaining mortality rate in COVID-19 patients; a systematic review and meta-analysis
Authors: Toloui Amirmohammad , Moshrefiaraghi Donya , Neishaboori Arian Madani , Safari Saeed , Yousefifard Mahmoud , Aghajani Mohammad Haji 
Published: December 2020

Abstract
Background

Raising knowledge over cardiac complications and managing them can play a key role in their recovery. In this study, we aim to investigate the evidence regarding the prevalence of cardiac complications and the resulting mortality rate in COVID-19 patients.
Results

The initial search resulted in 853 records, from which 40 articles were included. Overall analysis showed the prevalence of acute cardiac injury, heart failure and cardiac arrest were 19.46% (95% CI: 18.23–20.72), 19.07% (95% CI: 15.38–23.04) and 3.44% (95% CI: 3.08–3.82), respectively. Moreover, abnormal serum troponin level was observed in 22.86% (95% CI: 21.19–24.56) of the COVID-19 patients. Further analysis revealed that the overall odds of mortality is 14.24 [odds ratio (OR) = 14.24; 95% CI: 8.67–23.38] times higher, when patients develop acute cardiac injury. The pooled odds ratio of mortality when the analysis was limited to abnormal serum troponin level was 19.03 (OR = 19.03; 95% CI: 11.85–30.56).
Conclusion

Acute cardiac injury and abnormal serum troponin level were the most prevalent cardiac complications/abnormalities in COVID-19 patients. The importance of cardiac complications becomes crucial due to the higher mortality rate among patients with these complications. Thus, troponin screenings and cardiac evaluations are recommended to be performed in routine patient assessments.
Socio-cultural challenges in the implementation of COVID-19 public health measures: Results from a qualitative study in Punjab, Pakistan
Authors: Zakar Rubeena , Yousaf Farhan , Zakar Muhammad , Fischer Florian 
Published: December 2020

Abstract
Background: Informed public health measures are crucial to curb the COVID-19 pandemic. The socio-cultural context is important to understand the success or failure of implementing public health measures. This study explores the social and behavioral response to COVID-19 and unveils challenges in the implementation of related public health measures in Pakistan. Methods: Within this qualitative study, we conducted 34 telephonic/online in-depth interviews with youths, adults, old-age people, and healthcare professionals in the Punjab province of Pakistan. Framework analysis was used for data analysis. Results: People’s poor understanding about COVID-19 and the need for preventive measures were the major challenge in implementation of public health preventive strategies. Study participants reported that the lockdown strategy increased poverty and unemployment. People’s poor living conditions and living environment compelled them to not follow social distancing and restricting themselves to homes. Additionally, an underdeveloped healthcare system was one of the major challenges for Pakistan. False and misleading information about the disease had significant consequences for the COVID control program. In Pakistan, the culture of denial related to the epidemiology of COVID-19 were important challenges within the implementation of public health preventive measures. Conclusions: It is extremely important that public health experts and social scientists work together to understand the contextual socio-cultural factors which shape behaviors associated with the spread of a pandemic. This knowledge is needed in order to design and implement preventive strategies that could effectively work in the local context.
Two Target Genes Based Multiple Cross Displacement Amplification Combined with Lateral Flow Biosensor for the Detection of Mycobacrterium Tuberculosis Complex
Authors: Huang Junfei , Xiao Ziyu , Yang Xinggui , Chen Xu , Wang Xiaojuan , Chen Yijiang , Zheng Wenlin , Chen Wei , Chen Huijuan , Li Shijun 
Published: December 2020

Abstract
Background: Mycobacterium tuberculosis complex (MTBC) causes tuberculosis (TB), which is a global public health problem that seriously endangers public health. Hence, development of a new and rapid method to detect MTBC is of great significance for prevention and treatment of TB. Results: In this study, a multiple cross displacement amplification combined with nanoparticle-based lateral flow biosensor (MCDA-LFB) was developed to simultaneously detect two target genes (IS6110 and mpb64) of MTBC. One suit of specific multiple cross displacement amplification (MCDA) primers, which was designed for IS6110 and mpb64 gene, respectively, was validated through using the genomic DNA extracted from reference strain H37Rv. The MCDA products were analyzed using real-time turbidity curve, colorimetric indicator (Malachite Green, MG) and LFB. The conditions of amplification temperature and time were optimized and the established MCDA-LFB method was applied to detect the sputum specimens and MTBC strains from clinical samples. The results show that two sets of MCDA primers for the IS6110 and mpb64 genes have detected MTBC validly. The MCDA reaction conditions were optimized at 67 °C for 35 min. The limit of detection of MCDA assay based on IS6110 and mpb64 genes was 100 fg of genomic DNA template per reaction. The specificity of MCDA-LFB detection was 100%, and no cross-reactions for non-MTBC strains detection. The positive rate of MCDA-LFB for the detection of MTBC strains was equal to that of semi-nested automatic real-time PCR (Xpert MTB/RIF), and had a higher positive rate than acid-fast staining (AFS) when used for the detection of sputum samples. The whole procedure of MCDA-LFB, including genomic template preparation, MCDA reaction and products analysis, was completed with 70 min.Conclusion: The simplicity, rapidity, sensitivity and reliability of the MCDA-LFB based on IS6110 and mpb64 gene of MTBC developed in this study make it potentially significant for the prevention and treatment of TB.
Identification of SARS-CoV2 Main Protease Coldspots Suitable for Drug Targeting
Authors: Krishnamoorthy Navaneethakrishnan , Fakhro Khalid 
Published: December 2020

Abstract
Most attempts to target the novel coronavirus SARS-CoV2 are focusing on the main protease (Mpro) 1-9. However, >19,000 missense mutations in the Mpro have already been reported 10. The mutations encompassing 282 amino acid positions and these “hotspots” might change the Mpro structure and activity, potentially rendering novel antivirals and vaccines ineffective. Here we identified 24 mutational “coldspots” that have resisted mutation since the virus was first detected. We compared the structure-function relationship of these coldspots with several SARS-CoV2 Mpro X-ray crystal structures. We found that three coldspot residues (Leu141, Phe185 and Gln192) help to form the active site, while six (Gly2, Arg4, Tyr126, Lys137, Leu141 and Leu286) contribute to dimer formation that is required for Mpro activity. The surface of the dimer interface is more resistant to mutations compared to the active site. Interestingly, 16 coldspots are found in conserved patterns when compared with other coronaviruses. Importantly, several conserved coldpots are available on the surface of the active site and at the dimer interface for targeting. The identification and short list of these coldspots offers a new perspective to target the SARS-CoV2 Mpro while avoiding mutation-based drug resistance.