bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitators and Barriers to Implementation of Childhood Tuberculosis Control Program in Bangladesh: a Mixed-methods Study From BRAC Urban DOTS Centres in Dhaka
Authors: Pantha Sandesh , Aguinaldo Ma. Jennylyn , Bari S.M. Hasan-ul , Chowdhury Sayantan , Dendup Ugyen , Gupta Rajat Das , Sutradhar Ipsita , Bari Rahamatul , Sarker Malabika 
Published: August 2020

Abstract

BackgroundWorld Health Organisation (WHO) estimates childhood tuberculosis (tb) in high burden countries to be at least 10-15% of all cases. Despite intensive efforts on the childhood tb control program in Bangladesh, case detection rates stand below 5%. This study investigated the implementation pathway of childhood tb in Bangladesh. The study aims to identify the factors that enable and hinder the diagnosis and treatment of childhood tb in Bangladesh.MethodsAn exploratory-explanatory mixed-methods study was carried out in eight (top four and bottom four based on new case identification) urban DOTS (Directly Observed Treatment, Short-course) centres of the BRAC tb program in Dhaka Metropolitan City, Bangladesh. The study was conducted between September and December 2017. The knowledge, attitude, and practice (KAP) assessment on diagnosis and treatment of childhood tb were conducted among 111 Shasthya Shebika (SS), frontline health care workers engaged in the tb program. Field workers (n=32) and mothers of tb patients (n=4) participated in In-Depth Interviews. Key Informant Interviews (n=9) were conducted with program managers of BRAC and other key stakeholders involved in implementing the tuberculosis program in Bangladesh. ResultsThe survey showed a low level of knowledge on routes of transmission. The knowledge score was significantly associated with the recall of the components of training (p=0.02). Government stewardship, the presence of specific guidelines, capacity building of health workers, knowledge of frontline health workers were identified as key facilitators for the diagnosis and treatment of childhood tuberculosis. Major constraints identified included the presence of stigma, delays in seeking care, lack of diagnostic facilities, and poor engagement of private practitioners in the national tuberculosis program.ConclusionA triad of strategies including capacity building of frontline health care workers, use of recent technological advances in diagnosis, and continuous monitoring of the suspected or identified cases in the field have resulted in increased case notification of childhood tb in Bangladesh over the past few years. Frequent turnover and change of key positions in National Tuberculosis Program (NTP) and absenteeism of paediatricians in government hospitals were important barriers to implementation of childhood tb program.
Effects of Dietary Tongmai Granule Residue Supplementation on Growth Performance,&nbsp;Nutrient Digestibility,&nbsp;Blood Biochemical Parameters&nbsp;and Rumen Fermentation&nbsp;in&nbsp;Sheep
Authors: Zhang Pei , Sun Shiwen , Cheng Wenge , Abdallah Abedin , Sun Zewei , Zhong Qingzhen 
Published: August 2020

Abstract
The purpose of this study was to investigate the effects of Tongmai granule residue (TGR) on the growth performance, apparent nutrient digestibility, blood biochemical parameters, and rumen fermentation in Doper x Small Tail Han hybrid sheep. Twenty-four healthy female lambs (6–7 months of age; 29.64 ± 1.80 kg initial body weight) were randomly divided into 3 groups and fed for 75 days. The control group was fed a commercial concentrate and the other groups were fed diets supplemented with 10% and 15% TGR respectively. Dietary 15% TGR supplementation decreased average daily gain, apparent digestibility of neutral detergent fiber, but increased the feed conversion ratio, apparent digestibility of crude fat and organic matter in lambs (P < 0.05). The 10% TGR group significantly increased the apparent digestibility of organic matter (P < 0.05). Dietary supplementation of 10% and 15% TGR significantly increased serum high density lipoprotein cholesterol (HDL-C) content on day 15, IgG content on day 30, and IgA content on day 60 of the feeding period (P < 0.05). Dietary supplementation of 15% TGR significantly increased the content of IgA on the 30th day (P < 0.05), and significantly decreased blood urea nitrogen (BUN) on the 30th day (P < 0.05) of the feeding period. TGR at 15% significantly decreased the contents of acetic acid, propionic acid, butyric acid, and total volatile fatty acids (TVFA) in the rumen (P < 0.05), and significantly increased the pH, NH3-N concentration, and acetic acid: propionic acid ratio (P < 0.05). The results suggest that, the addition of TGR to diet can improve the apparent digestibility of crude fat and organic matter, and improve the anti-atherosclerosis ability and immune function of Doper x Small Tail Han hybrid female lambs. The dietary addition of 10% TGR yielded the best feeding effect in this experiment.
Assessing the Relationship Between Life Events and Internet Addiction Disorder Among Adolescents and College Students: A Protocol for Systematic Review and Meta-analysis
Authors: Wang Jun , Peng Wei , Hao Qinghong , Qiu Mimi , Chen Yalin , Tu Yang , Wang Yang , Zhu Tianmin 
Published: August 2020

Abstract
Background The increasing number of adolescents and college students who overuse the Internet is a global problem, brought a series of physical and mental harm to them. Systematic and standardized clinical treatment plan has not yet been formed, early intervention of its influencing factors, However, may help to reduce the symptoms of over-dependence to a certain extent. In this study, we will synthesize the present studies to evaluate the relationship and the mediating factors between life events and internet addiction disorder among adolescents and college students. Methods From inception to 25 March 2020, and contains the following databases: China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), China Science and Technology Journal Database (VIP), Wan Fang Data, PubMed, Embase, The Cochrane Library, and Web of Science, MEDLINE. All observational studies will be included. No restriction on gender, race, or nation. Two reviewers (JW and YT) will independently conduct study selection, data extraction, and study quality assessment, any discrepancies will be settled by a third author (WP). Study quality will be assessed by the Newcastle-Ottawa Scale. The main outcome is several scales include YDQ, CIAS-R, IAT, ASLEC, LES and other high-quality scales on IAD and life events. We will use Review Manager 5.3 software to assess bias risk and data synthesis of each study.DiscussionThe findings of this study may provide a helpful reference for the intervention of Internet addiction disorder among adolescents and college students.Systematic review registrationCRD42020177316
Electromagnetic-Guided Versus Endoscopic Placement of Nasoenteral Feeding Tubes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Wei Yaping , Jin Zheng , Zhu Ying , Hu Wei 
Published: August 2020

Abstract
Objectives: Current evidence supporting the utility of electromagnetic (EM)-guided method as the preferred technique for nasoenteral feeding tube placement is limited. We conducted a meta-analysis to compare the performance of EM-guided versus endoscopic placement.Methods: We searched several databases for all randomized controlled trials evaluating the EM-guided vs. endoscopic placement of nasoenteral feeding tubes up to 28 July 2020. Primary outcome was procedure success rate. Secondary outcomes included reinsertion rate, number of attempts, placement-related complications, tube-related complications, insertion time, total procedure time, patient discomfort, recommendation scores, length of hospital stay, mortality, and total costs. Results: Four trials involving 536 patients were qualified for the final analysis. There was no difference between the two groups in procedure success rate (RR 0.97; 95% CI: 0.91-1.03), reinsertion rate (RR 0.84; 95% CI: 0.59-1.20), number of attempts (WMD -0.23; 95% CI: -0.99-0.53), placement-related complications (RR 0.78; 95% CI: 0.41-1.49), tube-related complications (RR 1.08; 95% CI: 0.82-1.44), total procedure time (WMD -18.09; 95% CI: -38.66-2.47), length of hospital stay (WMD 1.57; 95% CI: -0.33-3.47), ICU mortality (RR 0.80; 95% CI: 0.50-1.29), in-hospital mortality (RR 0.87; 95% CI: 0.59-1.28), and total costs (SMD -1.80; 95% CI: -3.96-0.36). The EM group was associated with longer insertion time (WMD 4.3; 95% CI: 0.2-8.39), higher patient discomfort level (WMD 1.28; 95% CI: 0.46-2.1), and higher recommendation scores (WMD 1.67; 95% CI: 0.24-3.10).Conclusions: EM-guided placement showed similar efficacy, safety and cost-effectiveness when compared with endoscopic placement of nasoenteral feeding tubes.
Multiple population structure of the giant eel Anguilla marmorata in Thua Thien Hue, Vietnam base on COI sequences
Authors: Linh Nguyen Quang , Huyen Kieu Thi 
Published: August 2020

Abstract
The giant mottled eel Anguilla marmorata is a species of great economic, ecological, and conservative values in the Southeast Asian region. The research aims to conservation and evaluation of the genetic diversity of A. marmorata populations living in Thua Thien Hue (TTH), Vietnam. The sequencing of the barcode region of the cytochrome c oxidase subunit 1 gene was carried out for 48 individuals of A. marmorata elvers, which were collected from five different ecosystem regions. The sequences were analyzed using various genetic, phylogenetic, and population analyses to assess their variability. A total of 20 polymorphic sites and 17 haplotypes were identified. Extremely low fixation (Fst = -0.073 – 0.003; < 0.05) was found for A. marmorata populations in the region. The populations showed signs of recent populations’ expansion, besides negative Tajima’s D test, Fu’s Fs, Fu and Li’s D* and F* test values. The genetic evolution of eel occurs in a randomized pattern over a large population, with the likelihood of rare alleles appearing in the population. In TTH (Viet Nam) territories, we indicated the five areas for conservation units with moderate eels’ populations’ diversity.
A Multicenter Validation Study of the Deep Learning-based Early Warning Score for Predicting in-hospital Cardiac Arrest in Patients Admitted to General Wards
Authors: Lee Yeon Joo , Cho Kyung-Jae , Kwon Oyeon , Park Hyunho , Lee Yeha , Kwon Joon-Myoung , Park Jinsik , Kim Jung Soo , Lee Man-Jong , Kim Ah Jin , Ko Ryoung-Eun , Jeon Kyeongman , Jo You Hwan 
Published: August 2020

Abstract
Background: The recently developed deep learning (DL)-based early warning score (DEWS) has shown a potential in predicting deteriorating patients. We aimed to validate DEWS in multiple centers and compare the prediction, alarming and timeliness performance with those of the modified early warning score (MEWS) to identify patients at risk for in-hospital cardiac arrest (IHCA).Methods: This retrospective cohort study included adult patients admitted to the general wards of five hospitals during a 12-month period. We validated DEWS internally at two hospitals and externally at the other three hospitals. The occurrence of IHCA within 24 hours of vital sign observation was the outcome of interest. We used the area under the receiver operating characteristic curve (AUROC) as the main performance metric.Results: The study population consisted of 173,368 patients (224 IHCAs). The predictive performance of DEWS was superior to that of MEWS in both the internal (AUROC: 0.860 vs. 0.754, respectively) and external (AUROC: 0.905 vs. 0.785, respectively) validation cohorts. At the same specificity, DEWS had a higher sensitivity than MEWS, and at the same sensitivity, DEWS had a lower mean alarm count than MEWS, with nearly half of the alarm rate in MEWS. Additionally, DEWS was able to predict more IHCA patients in the 24 to 0.5 hours before the outcome.Conclusion: Our study showed that DEWS was superior to MEWS in the three key aspects (IHCA predictive, alarming, and timeliness performance). This study demonstrates the potential of DEWS as an effective, efficient screening tool in rapid response systems (RRSs) to identify high-risk patients.
CPAP Use in Covid-19 Patients: A Retrospective Observational Study in the Emergency Department.
Authors: Capsoni Nicolo , Privitera Daniele , Mazzone Annamaria , Airoldi Chiara , Angaroni Laura , Forni Elisa , Pierotti Federico , Rocca Eugenia , Bergamaschi Marta , Albertini Valentina , Molin Alberto Dal , Vincenti Fabrizio , Bellone Andrea 
Published: August 2020

Abstract
BackgroundDuring COVID-19 outbreak, with the increasing number of patients presenting with acute respiratory failure (ARF), a large use of non-invasive positive pressure ventilation (NIPPV) was done in the Emergency Departments (EDs) and medical wards despite the lack of recommendations. We aimed to assess the use of continuous positive airway pressure (CPAP) in the ED. The primary endpoint was the rate of CPAP failure and the need of endotracheal intubation (ETI). Secondary endpoints were in-hospital mortality and intensive care unit (ICU) and in-hospital length of stay. Study design and MethodsA retrospective observational study enrolling adult patients admitted to the ED of Niguarda Hospital, Milan, Italy, with ARF due to COVID-19 pneumonia from March 18th to April 18th 2020, was conducted. Only patients who strictly followed a local CPAP protocol were enrolled. ResultsA total of 52 patients were included in this study. 38 patients (73%) were judged eligible for ETI. 18 (34.6%) were intubated. 16 (30.8%) patients died: 7 (38.9%) and 9 (26.5%) in the ETI and non-ETI group respectively. The median hospital length of stay was different in ETI and non-ETI patients: 26 days [IQR 16-37] vs 15 days [IQR 9-17] (p=0.005). The median invasive mechanical ventilation time was 11 days [IQR 7-21] with an ICU length of stay of 14.5 days [IQR 10-28]. During the CPAP trial, variations between ETI and non-ETI patients over time were found for positive end-expiratory pressure (PEEP) (p=0.003) and respiratory rate (RR) (p=0.059).ConclusionsA short closed monitored CPAP trial could be considered for ARF due to COVID-19 pneumonia before considering ETI. A progressive PEEP titration should target patient’s SpO2 improvement and RR reduction. More studies are needed to evaluate the efficacy and predictors of failure of CPAP and NIPPV in patients with ARF due to COVID-19 pneumonia.
Fitbit data show poor correlation with measures of activity and sleep among hospitalized general medicine patients
Authors: Wu Robert Clark , Patel Vikas , Moosa Sabreena , Langer Laura , MacMillan Thomas E. , Cavalcanti Rodrigo B. , Cram Peter , Gunaratne Keith , Bayley Mark 
Published: August 2020

Abstract
BackgroundWearable devices such as Fitbits may provide important insights about hospitalized patients that include data on low activity and poor sleep. Monitoring this information could spur interventions to improve mobility and sleep which may reduce the adverse effects associated with hospitalization. However, there is a lack of studies assessing the accuracy of wearables in hospitalized medical patients. The purpose of our study was to determine the accuracy of Fitbit heart rate, sleep and physical activity in hospitalized medical patients.MethodsWe conducted a prospective cohort feasibility study enrolling 50 medical inpatients at two hospitals providing them with a Fitbit Charge. Our main measures were Fitbit heart rate, sleep and activity data as well as nurse recorded heart rates, patient reported sleep, and nurse assessments of activity.ResultsOf the 50 patients who consented to the study, 47 patients wore the devices. Comparing pairs of heart rate data from Fitbit and nurse recorded vital signs for the same minute, there were 261 pairs available for comparison. The mean difference was 0.45 bpm (SD: 13.0, Pearson correlation: 0.68 P<0.001) and the 95% limits of agreement were -25 to 26 bpm. The association between the patient-reported sleep score and Fitbit total sleep duration was 0.19 (P=0.24) and between the self-reported hours of sleep and Fitbit total sleep duration was 0.21 (P=0.21). The correlation between nurse-recorded activity and Fitbit daily steps was 0.06 (P=0.52). ConclusionsFitbit heart rates correlated well with nurse-recorded heart rate but did not correlate well with nurse assessments of activity nor with patient self-assessment of sleep. This study highlights limitations of the accuracy of current wearable wrist-worn device algorithms in activity and sleep detection in patients in hospital. The findings call into question the validity of Fitbits for assessment of patient activity and sleep in the hospital setting and suggest that they should not be routinely used without further validation.Trial RegistrationClinicalTrials.gov NCT03646435
WITHDRAWN: Early Post-partum Glucose Intolerance, Metabolic Syndrome and Gestational Diabetes Mellitus Determinants After Assisted Conception: A Prospective Cohort Study
Authors: Kouhkan Azam , Hosseini Roya , Baradaran Hamid Reza , Arabipoor Arezoo , Cheraghi Rezvaneh , Moini Ashraf , Malekzadeh Farideh , Khamseh Mohammad E. 
Published: August 2020

Abstract
Background: This study aimed to determine the prevalence of postpartum metabolic syndrome (MetS), glucose intolerance and other determinants, 6-12 weeks postpartum in women with assisted reproduction technology conception gestational diabetes mellitus diagnosis (ART-GDM) compared to women with spontaneous conception and GDM diagnosis (SC-GDM).Methods: In this prospective cohort study, two groups consisted of 62 ART-GDM and 64 SC-GDM singleton pregnant women were followed 6-12 weeks after delivery for postpartum MetS. Fasting glucose, 75-g 2-h OGTT and lipid profile were assessed. Waist and hip circumference, and systolic and diastolic blood pressures (BP) were measured at post- partum. Clinical, para clinical and obstetric data were recorded from registry offices. The prevalence of MetS and glucose intolerance were determined. Predictors of Mets and glucose intolerance were determined by logistic regression. Results: The prevalence of postpartum MetS was 20.8% in ART-GDM women and 10.9% in SC-GDM, P=0.123). Mean postpartum BMI and systolic BP were significantly higher in the ART-GDM group (P=0.016 and P=0.027, respectively). Adverse pregnancy outcomes were significantly higher in the ART-GDM group. Postpartum glucose intolerance prevalence did not vary significantly between the groups. Family history of diabetes was a predictive factor for postpartum MetS and glucose intolerance 6-12 weeks after delivery.Conclusions: Early postpartum MetS and glucose intolerance prevalence after assisted conception did not vary significantly; however, postpartum BMI and systolic BP were significantly higher in the ART-GDM group. Lifestyle modification program and long-term health care of ART women with GDM diagnosis can be recommended. Further studies with larger sample size and longer follow-up are necessary to verify our findings.
Maternal Factors of Newborn Low Birthweight in Malaria Endemic Settings of Nanoro, Rural Burkina Faso
Authors: Lingani Moussa , Zango Henri S. , Valéa Innocent , Valia Daniel , Sanou Maïmouna , Samandoulougou Sékou O. , Robert Annie , Tinto Halidou , Dramaix Michèle , Donnen Philippe 
Published: August 2020

Abstract
Background. In sub-Saharan Africa, the intermittent preventive treatment of malaria in pregnancy with sulphadoxine pyrimethamine (IPTp-SP) strategy is recommended to limit malaria consequences on birth outcomes. Ten year after IPTp-SP was adopted in Burkina Faso, we assessed the magnitude of low birthweight (LBW) and its maternal factors in Nanoro.Methods. A secondary analysis of data from a cross-sectional study was carried out in women who gave birth at Nanoro peripheral health centers using a binary multivariate logistic regression. Maternal socio-demographic factors, gyneco-obstetrical history and relevant medical characteristics were evaluated to identify associated factors. A p-value less than 0.05 was considered statistically significant.Results. Of 291 delivery records examined, 14 % of women received three or more doses of SP while 80% used bed nets the night before their admission for delivery. Malaria was detected in 36.1% and anemia in 52.9% of women. The average neonate birthweight was 2933 g and 12 % of them were born with a low birthweight. After multivariate analysis, first delivery (OR = 8.84, [95% CI: 3.72-21.01]), and being multiparous with history of stillbirth (OR = 5.03, [95% CI: 1.54-16.40]) were significantly associated with an increased risk of LBW.Conclusion. LBW is still prevalent in rural Nanoro and the uptake of three or more doses of SP for the IPTp was low. In addition, to improving the coverage of IPTp-SP to improve birthweight, an extension of the target of antenatal care to other known causes of LBW including curable sexually transmitted infections may be necessary.
Novel role of AGT gene in aplastic anaemia among paediatric patients based on gene expression profiling
Authors: Adhikari Sarmistha , MANDAL PARAMITA 
Published: August 2020

Abstract
ObjectivesSevere aplastic anemia is characterized by a hypocellular bone marrow and peripheral cytopenia. Mesenchymal stem cells (MSCs) play a crucial role in haematopoietic stem cells (HSCs) development and the microenvironment suitable for haematopoiesis. Investigation of the therapeutic targets by paediatric patient-specific gene expression analysis of the MSCs can be important for diagnosis.MethodsThe study was based on freely available miRNA and host gene expression in NCBI GEO dataset. Microarray based gene expression profiles (GSE33812) of MSCs for five paediatric aplastic anaemia patients and healthy controls were generated using Agilent-014850 platform and the data was downloaded from the database.ResultsMSCs gene expression profiling distinguished between healthy controls, children with aplastic anemia. Angioteninogen (AGT) gene involved in ERK1/ERK2 cascade, cyotokine secretion, metabolic processes was strongly down-regulated among all the patients with aplastic anemia. Emerging role of various transcription factors binding to this gene was identified as a new avenue of therapeutic application.ConclusionsAs a potential diagnostic tool, patient-specific gene expression profiling of MSCs made it possible to make the difficult diagnosis of most patients with aplastic anemia.
Clinical Manifestations of Covid-19 Disease; Exploring the Experiences of Infected Health-Care Providers.
Authors: Toulabi Tahereh , Veiskramian Atefeh , Azadi Abas , Heydari Heshmatolah 
Published: August 2020

Abstract
Background: Covid-19 is a novel disease with many unknown clinical and managemental dimensions. To effectively diagnose, control, and treat the disease, it is required to divulge its clinical symptoms and their qualities. On the other hand, no one can better interpret the clinical symptoms than the caregivers infected by the disease. So, the aim of this study was to exploring the experiences of infected health-care providers about clinical manifestations of Covid-19 disease.Methods: The present qualitative research was conducted using the conventional content analysis method in Iran from March to Jun 2020. Participants in this study included infected health care providers with Covid-19, who were selected based on purposeful sampling method. The data was collected by 18 phone call interviews and analyzed according Lundman and Graneheim approach.Results: Qualitative data analysis revealed 10 categories including respiratory disorders, fever and chills, body pain, fatigue, headache, skin disorders, gastrointestinal disorders, taste and olfactory disturbances, insomnia and also stress and anxiety.Conclusion: Patients with Covid-19 may experience specific or non-specific disorders. It is necessary to consider people with non-specific manifestations as suspicious cases and screen them with proper diagnostic tests. This can help to identify true positive patients and provide them with more effective health cares, and prevent further spread of the disease by isolating suspected individuals.Trial registration number: Not applicable