bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Structure and Magnetic Properties of Mn2Tb2 Tetranuclear Complex with p‐tert‐Butylthiacalix[4]arene
Authors: Aldoshin Sergey M. , Antipin Igor S. , Kniazeva Mariya V. , Korchagin Denis V. , Morgunov Roman B. , Ovsyannikov Alexander S. , Palii Andrey V. , Sanina Nataliya A. , Shilov Gennadiy V. , Solovieva Svetlana E. 
Published: February 2020

AbstractA new tert‐buthylthiacalix[4]arene‐based tetranuclear 3d‐4f metal complex with the Mn2Tb2 core has been synthesized and its molecular and crystal structures have been studied by X‐ray diffraction. The complex geometry is similar to that of the earlier synthesized tert‐buthylthiacalix[4]arene‐based M2Ln2 complexes with M=Mn(II), Co(II), and Ln=Gd, Pr, Eu, but unlike those systems, it exhibits intricated cooperative low‐temperature magnetic properties arising from the presence of intercluster interactions. At T<8.5 K the complex shows weak spin‐canted ferromagnetism and field induced metamagnetic phase transition. The paramagnetic behavior observed at temperatures higher than 8.5 K is similar to that previously reported for the Mn2Gd2 complex, this being indicative of the existence of competitive ferro‐ and antiferromagnetic intracluster interactions.
Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet‐like particles
Authors: Chee Eunice , Nandi Seema , Nellenbach Kimberly , Mihalko Emily , Snider Douglas B. , Morrill Landon , Bond Andrew , Sproul Erin , Sollinger Jennifer , Cruse Glenn , Hoffman Maureane , Brown Ashley C. 
Published: February 2020

AbstractPlatelets crucially facilitate wound healing but can become depleted in traumatic injury or chronic wounds. Previously, our group developed injectable platelet‐like particles (PLPs) comprised of highly deformable, ultralow crosslinked pNIPAm microgels (ULCs) coupled to fibrin binding antibodies to treat post‐trauma bleeding. PLP fibrin‐binding facilitates homing to sites of injury, promotes clot formation, and, due to high particle deformability, induces clot retraction. Clot retraction augments healing by increasing clot stability, enhancing clot stiffness, and promoting cell migration into the wound bed. Because post‐traumatic healing is often complicated by infection, the objective of these studies was to develop antimicrobial nanosilver microgel composite PLPs to augment hemostasis, fight infection, and promote healing post‐trauma. A key goal was to maintain particle deformability following silver incorporation to preserve PLP‐mediated clot retraction. Clot retraction, antimicrobial activity, hemostasis after trauma, and healing after injury were evaluated via confocal microscopy, colony‐forming unit assays, a murine liver trauma model, and a murine full‐thickness injury model in the absence or presence of infection, respectively. We found that nanosilver incorporation does not affect base PLP performance while bestowing significant antimicrobial activity and enhancing infected wound healing outcomes. Therefore, Ag‐PLPs have great promise for treating hemorrhage and improving healing following trauma.
A novel optical probe based on d‐penicillamine‐functionalized graphene quantum dots: Preparation and application as signal amplification element to minoring of ions in human biofluid
Authors: Pashazadeh‐Panahi Paria , Hasanzadeh Mohammad , Eivazzadeh‐Keihan Reza 
Published: February 2020

AbstractIn this study, d‐penicillamine‐functionalized graphene quantum dots (DPA‐GQD) has been synthesized, which significantly increases the fluorescence intensity of GQD. We used this simple fluorescent probe for metal ions detection in human plasma samples. Designed DPA‐GQD respond to Hg2+, Cu2+, Au2+, Ag+, Co2+, Zn2+, and Pb2+ with high sensitivity. The fluorescence intensity of this probe decreased significantly in the presence of metal ions such as, Hg2+, Cu2+, Au2+, Ag+, Co2+, Zn2+, and Pb2+. In this work, a promising probe for ions monitoring was introduced. Moreover, DPA‐GQD probe has been tested in plasma samples. The functionalized DPA‐GQDs exhibits great promise as an alternative to previous fluorescent probes for bio‐labeling, sensing, and other biomedical applications in aqueous solution.
Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2
Authors: Liu Zhixin , Xiao Xiao , Wei Xiuli , Li Jian , Yang Jing , Tan Huabing , Zhu Jianyong , Zhang Qiwei , Wu Jianguo , Liu Long 
Published: February 2020

AbstractFrom the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS‐CoV) and Middle East respiratory syndrome coronavirus (MERS‐CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths, respectively. Currently, a novel coronavirus (SARS‐CoV‐2), which has become the cause of the outbreak of Coronavirus Disease 2019 (COVID‐19), was discovered. Until 18 February 2020, there were 72 533 confirmed COVID‐19 cases (including 10 644 severe cases) and 1872 deaths in China. SARS‐CoV‐2 is spreading among the public and causing substantial burden due to its human‐to‐human transmission. However, the intermediate host of SARS‐CoV‐2 is still unclear. Finding the possible intermediate host of SARS‐CoV‐2 is imperative to prevent further spread of the epidemic. In this study, we used systematic comparison and analysis to predict the interaction between the receptor‐binding domain (RBD) of coronavirus spike protein and the host receptor, angiotensin‐converting enzyme 2 (ACE2). The interaction between the key amino acids of S protein RBD and ACE2 indicated that, other than pangolins and snakes, as previously suggested, turtles (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis) may act as the potential intermediate hosts transmitting SARS‐CoV‐2 to humans.
Salivary biomarkers in the context of gingival inflammation in children with cystic fibrosis
Authors: Yucel Zeynep Pinar Keles , Silbereisen Angelika , Emingil Gulnur , Tokgoz Yavuz , Kose Timur , Sorsa Timo , Tsilingaridis Georgios , Bostanci Nagihan 
Published: February 2020

AbstractBackgroundCystic fibrosis (CF) is a life‐threatening chronic inflammatory disease in children due to respiratory complications. Saliva could serve as a reservoir of bacterial colonization and potentially reflect systemic inflammation. This study investigated whether salivary triggering receptor expressed on myeloid cells 1 (TREM‐1), peptidoglycan recognition protein 1 (PGLYRP1), interleukin (IL)‐1β, and calprotectin are associated with CF or reflect concomitant gingival inflammation.MethodsTen CF (aged 3 to 12 years) and 10 systemically healthy (SH) age‐ and sex‐matched children (C) were enrolled in the study. Individuals with CF underwent routine laboratory determinations. Probing depth, gingival index (GI), plaque index (PI), and bleeding on probing (BOP) were recorded on fully erupted teeth and saliva samples collected. Salivary TREM‐1, PGLYRP1, IL‐1β, and calprotectin were analyzed by enzyme‐linked immunosorbent assay.ResultsChildren with CF had significantly higher BOP scores (P = 0.001) and calprotectin levels (P = 0.017) compared with the C group. TREM‐1, PGLYRP1, and IL‐1β could not distinguish between CF and SH but showed positive correlation with GI, PI, and BOP in both groups. Calprotectin levels positively correlated with procalcitonin (P = 0.014), thrombocyte counts (P = 0.001), mean platelet volume (P = 0.030), and with PGLYRP1 (P = 0.019) and IL‐1β (P = 0.013) in CF children. Receiver operating characteristic curve analysis for calprotectin (CFvsC) showed an area under the curve of 0.79 (95% CI 0.58 to 0.99, P = 0.034).ConclusionsCF children presented with higher gingival inflammation scores and salivary calprotectin levels, that correlated with systemic inflammatory markers. Salivary calprotectin levels were not associated with periodontal parameters. Hence, preliminary data demonstrate that salivary calprotectin might have a chairside diagnostic potential for CF in children.
Effects of Wild Pig Disturbance on Forest Vegetation and Soils
Authors: Gray Steven M. , Roloff Gary J. , Kramer Daniel B. , Etter Dwayne R. , Vercauteren Kurt C. , Montgomery Robert A. 
Published: February 2020

ABSTRACTIn North America, wild pigs (Sus scrofa; feral pigs, feral swine, wild boars) are a widespread exotic species capable of creating large‐scale biotic and abiotic landscape perturbations. Quantification of wild pig environmental effects has been particularly problematic in northern climates, where they occur only recently as localized populations at low densities. Between 2016 and 2017, we assessed short‐term (within ~2 yrs of disturbance) effects of a low‐density wild pig population on forest features in the central Lower Peninsula of Michigan, USA. We identified 16 8‐ha sites using global positioning system locations from 7 radio‐collared wild pigs for sampling. Within each site, we conducted fine‐scale assessments at 81 plots and quantified potential disturbance by wild pigs. We defined disturbance as exposure of overturned soil, often resulting from rooting behavior by wild pigs. We quantified ground cover of plants within paired 1‐m2 frames at each plot, determined effects to tree regeneration using point‐centered quarter sampling, and collected soil cores from each plot. We observed less percent ground cover of native herbaceous plants and lower species diversity, particularly for plants with a coefficient of conservatism ≥5, in plots disturbed by wild pigs. We did not observe an increase in colonization of exotic plants following disturbance, though the observed prevalence of exotic plants was low. Wild pigs did not select for tree species when rooting, and we did not detect any differences in regeneration of light‐ and heavy‐seeded tree species between disturbed or undisturbed plots. Magnesium and ammonium content in soils were lower in disturbed plots, suggesting soil disturbance accelerated leaching of macronutrients, potentially altering nitrogen transformation. Our study suggested that disturbances by wild pigs, even at low densities, alters short‐term native herbaceous plant diversity and soil chemistry. Thus, small‐scale exclusion of wild pigs from vulnerable and rare plant communities may be warranted. © 2020 The Wildlife Society.
Process mining and industrial applications: A systematic literature review
Authors: Corallo Angelo , Lazoi Mariangela , Striani Fabrizio 
Published: February 2020

AbstractCurrently, the process mining aims at an automatic extraction of process knowledge from the event logs recorded by information systems, and, therefore, by using these techniques, it becomes possible to grasp the complex nature of industrial processes. In fact, most of the industrial processes change over time, and through the process mining techniques, it is possible to analyse these processes as if they were in a steady state. Starting to this concept, in this paper, we provide a systematic literature review that analyses the applications of process mining techniques in relation to the industrial context in order to highlight the importance of these new techniques in this scenario. To do the systematic literature review, we use the Tranfield approach (2003), and we identify the most interesting papers in the sector under analysis. After that, an in‐depth analysis of the selected papers was carried out.
Implementation of a “real‐world” learning health system: Results from the evaluation of the Connected Health Cities programme
Authors: Steels Stephanie , Ainsworth John , van Staa Tjeerd P. 
Published: February 2020

AbstractBackgroundThe “learning health system” has been proposed to deliver better outcomes for patients and communities by analyzing routinely captured health information and feeding back results to clinical staff. This approach has been piloted in the Connected Health Cities (CHC) programme in four regions in the North of England. This paper presents the results of the evaluation of this program conducted between February and December 2018.MethodsFifty nine semistructured interviews were completed with a mix of CHC programme staff and external partners who had contributed to the delivery of the CHC programme. Interviews were audio recorded and transcribed verbatim. This also included the review of project documentation including project reports and minutes of project group meetings, in addition to a short online survey that was completed by 31 members of CHC programme staff. Data were analyzed thematically.ResultsTwo overarching themes emerged through the thematic analysis of participant interview: (a) challenges in the implementation of learning health system pathways, and (b) benefits to the CHC approach for both staff and patients. In particular, time constraints in delivering an ambitious program of work, data quality, and accessibility, as well as the long‐term sustainability of the CHC programme were noted as key challenges in implementing a LHS at scale.ConclusionsThe findings from this evaluation provide valuable insight into creating learning health system at scale, including the potential benefits and likely challenges.
The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
Authors: Chen Ting‐Yun , Li Xiaoyun , Hung Ching‐Hsia , Bahudhanapati Harinath , Tan Jiangning , Kass Daniel J. , Zhang Yingze 
Published: February 2020

AbstractBackgroundRelaxin/relaxin family peptide receptor 1 (RXFP1) signaling is important for both normal physiology and disease. Strong preclinical evidence supports relaxin as a potent antifibrotic molecule. However, relaxin‐based therapy failed in clinical trial in patients with systemic sclerosis. We and others have discovered that aberrant expression of RXFP1 may contribute to the abnormal relaxin/RXFP1 signaling in different diseases. Reduced RXFP1 expression and alternative splicing transcripts with potential functional consequences have been observed in fibrotic tissues. A relative decrease in RXFP1 expression in fibrotic tissues—specifically lung and skin—may explain a potential insensitivity to relaxin. In addition, receptor dimerization also plays important roles in relaxin/RXFP1 signaling.MethodsThis review describes the tissue specific expression, characteristics of the splicing variants, and homo/heterodimerization of RXFP1 in both normal physiological function and human diseases. We discuss the potential implications of these molecular features for developing therapeutics to restore relaxin/RXFP1 signaling and to harness relaxin's potential antifibrotic effects.ResultsRelaxin/RXFP1 signaling is important in both normal physiology and in human diseases. Reduced expression of RXFP1 in fibrotic lung and skin tissues surrenders both relaxin/RXFP1 signaling and their responsiveness to exogenous relaxin treatments. Alternative splicing and receptor dimerization are also important in regulating relaxin/RXFP1 signaling.ConclusionsUnderstanding the molecular mechanisms that drive aberrant expression of RXFP1 in disease and the functional roles of alternative splicing and receptor dimerization will provide insight into therapeutic targets that may restore the relaxin responsiveness of fibrotic tissues.
Dual‐failure restorability analysis of span‐restorable meta‐mesh networks
Authors: Castillo Andres , Nakashima‐Paniagua Tetsuhei , Doucette John 
Published: February 2020

AbstractThe span‐restorable meta‐mesh model was previously designed as a cutting‐edge technique that enhanced the spare capacity efficiency in low average nodal degree networks. In this technique, lightpaths that fully traverse chains of degree‐2 nodes are provided with a logical express bypass span allowing a distinction between the internal and external working flow capacity that transit the chain. In the event of span failure, lightpaths which would normally traverse the chain in its entirety are allowed to fail back to its anchor nodes such that only the intrachain flow requires allocation of spare capacity. Previous work on the meta‐mesh design considered only single failure restorability. The work herein analyzes dual span failure situations by developing two new integer linear programming models. The first model provides the minimum total cost of designing a meta‐mesh network capable of withstanding dual span failure scenarios. The second model offers a maximization of the dual failure restorability by minimizing the number of nonrestored working capacities with a given limit of total spare capacity investment. Experiments are performed on six master test‐case networks of various topologies and scales.
Oral care quality—Do humanity aspects matter? Nursing staff's and older people's perceptions
Authors: Andersson Maria , Wilde‐Larsson Bodil , Persenius Mona 
Published: February 2020

AbstractAim(a) To describe and compare perceptions of humanity aspects of oral care quality in relation to nursing staff in short‐term care units and intensive care units and older people in short‐term care units and their person‐related conditions; and (b) to compare humanity aspects of oral care quality perceptions between nursing staff and older people in short‐term care units.DesignCross‐sectional study. Self‐reported questionnaire and clinical assessments.MethodsNursing staff (N = 417) and older people (N = 74) completed the modified Quality of Care from a Patient Perspective instrument and person‐related items. Older people's oral health status was clinically assessed using the Revised Oral Assessment Guide. Data were analysed using descriptive and analytic statistics. The data were collected from 2013–2016.ResultsNursing staff's perceptions of humanity aspects of oral care quality were related to gender, work role and care environment. Older people's perceptions of humanity aspects of oral care quality were related to self‐reported physical health. Nursing staff in short‐term care units perceived the subjective importance of humanity aspects of oral care quality higher compared with older people in short‐term care units.
High‐Resolution Three‐Dimensional Photonic Scan‐Derived Equations Improve Body Surface Area Prediction in Diverse Populations
Authors: Ashby‐Thompson Maxine , Ji Ying , Wang Jack , Yu Wen , Thornton John C. , Wolper Carla , Weil Richard , Chambers Earle C. , Laferrère Blandine , Pi‐Sunyer F. Xavier , Gallagher Dympna 
Published: February 2020

ObjectiveEquations for predicting body surface area (BSA) produce flawed estimates, especially for individuals with obesity. This study aimed to compare BSA measured by a three‐dimensional photonic scanner (3DPS) with BSA predicted by six commonly cited prediction equations and to develop new prediction equations if warranted.MethodsThe 3DPS was validated against manual measurements by breadth caliper for body thicknesses measured at three anatomical sites on a mannequin. BSA was derived from 3DPS whole‐body scans of 67 males and 201 females, aged 18 to 83 years, with BMI between 17.8 and 77.8 kg/m2 and varied races/ethnicities.ResultsWidth and depth measurements by 3DPS and caliper were within 1%, except for hip, with an error of 1.8%. BSA3DPS differed from BSA predicted by each equation (P < 0.05), except for males by DuBois and DuBois (P = 0.60), Tikuisis (P = 0.27), and Yu (P = 0.45) and for females by Tikuisis (P = 0.70). The combined and sex‐specific equations obtained by regressing ln(BSA) on ln(weight in kilograms [W]) and ln(height in meters [H]) are as follows (R2 and SEE correspond to ln[BSA]): combined, BSA3DPS = 0.03216 × W0.4904 × H0.3769, R2 = 0.982, SEE = 0.021; males, BSA3DPS = 0.01624 × W0.4725 × H0.5231; and females, BSA3DPS = 0.01522 × W0.4921 × H0.5231, R2 = 0.986, SEE = 0.019.ConclusionsNew height and weight BSA equations improve BSA estimation in individuals with BMI ≥ 40 and in African Americans, Hispanic Americans, and Asian Americans.
Simulation and Visual Tester Verification of Solid Propellant Slurry Vacuum Plate Casting
Authors: Yue Wu , Zhuo Li , Rong Lu 
Published: February 2020

AbstractUsing an improved Carreau constitutive model, a numerical simulation of the casting process of a type of solid propellant slurry vacuum plate casting was carried out using the Flow3D software. Through the flow process in the orifice flow channel and the combustion chamber, the flow velocity of the slurry passing through the plate flow channel was quantitatively analyzed, and the viscosity, shear rate, and leveling characteristics of the slurry in the combustion chamber were qualitatively analyzed and predicted. The pouring time, pouring quality, and flow state predicted by the numerical simulation were verified using a visual tester consisting of a vacuum plate casting system in which a pouring experiment was carried out. Studies have shown that HTPB three‐component propellant slurry is a typical yielding pseudoplastic fluid. When the slurry flows through the flower plate and the airfoil, the fluid shear rate reaches its maximum value and the viscosity of the slurry decreases. The visual pouring platform was built and the experiment was controlled according to the numerically‐calculated parameters, ensuring the same casting speed. The comparison between the predicted casting quality and the one obtained in the verification test resulted in an error less than 10 %. Moreover, the error between the simulated casting completion time and the process verification test result was also no more than 10 %. Last, the flow state of the slurry during the simulation was consistent with the one during the experimental test. The overall leveling of the slurry in the combustion chamber was adequate and no relatively large holes and flaws developed during the pouring process.
Pharmacological characterization of a novel, potent, selective, and orally active fatty acid amide hydrolase inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide] in rats: Potential for the treatment of inflammatory pain
Authors: Endo Toshiya , Takeuchi Takashi , Maehara Shunsuke 
Published: February 2020

AbstractRecently, we identified a novel fatty acid amide hydrolase (FAAH) inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide]. The aim of the present study is to characterize the pharmacological profile of PKM‐833 in vitro and in vivo. PKM‐833 showed potent inhibitory activities against human and rat FAAH with IC50 values of 8.8 and 10 nmol/L, respectively, 200‐fold more selectivity against other 137 molecular targets, and irreversible mode of action. In pharmacokinetic and pharmacodynamic studies, PKM‐833 showed excellent brain penetration and good oral bioavailability, and elevated anandamide (AEA) concentrations in the rat brain. These data indicate that PKM‐833 is a potent, selective, orally active, and brain‐penetrable FAAH inhibitor. In behavioral studies using rat models, PKM‐833 significantly attenuated formalin‐induced pain responses (3 mg/kg) and improved mechanical allodynia in complete freund's adjuvant (CFA)‐induced inflammatory pain (0.3‐3 mg/kg). On the other hand, PKM‐833 did not show the analgesic effects against mechanical allodynia in chronic constriction injury (CCI)‐induced neuropathic pain up to 30 mg/kg. Regarding side effects, PKM‐833 had no significant effects on catalepsy and motor coordination up to 30 mg/kg. These results indicate that PKM‐833 is a useful pharmacological agent that can be used to investigate the role of FAAH and may have therapeutic potential for the treatment of inflammatory pain without undesirable side effects.