bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective use of dupilumab for eosinophilic gastritis concomitant with severe asthma
Authors: Takeshige Tomohito , Koyama Ryo , Motomura Hiroaki , Okajima Akifumi , Nishioki Toshihiko , Watanabe Junko , Yae Toshifumi , Kido Kenji , Takahashi Kazuhisa 
Published: December 2024

Abstract
Background
Eosinophilic gastrointestinal diseases (EGIDs) are chronic immune-mediated inflammatory disorders characterized by gastrointestinal symptoms and eosinophilic inflammation in specific regions of the gastrointestinal tract. “Eosinophilic gastritis” (EoG) refers to the condition in which the stomach is involved. In patients with EoG, approved treatment options are restricted despite the high mortality associated with the condition. Dupilumab is a human monoclonal antibody directed against the interleukin (IL)-4 receptor α subunit and inhibits the signaling pathways of both IL-4 and IL-13. The real-world data on the effectiveness of dupilumab for EoG are limited. We present the case of a patient with EoG and accompanying severe asthma who demonstrated improvement with dupilumab administration.

Case presentation
A 35-year-old woman who had been treated for asthma complained of worsening intermittent upper abdominal pain. Her dyspnea aggravated and she was admitted to our hospital for asthma exacerbation. Despite the improvement in her asthma symptoms with systemic corticosteroids, her abdominal pain persisted. Upper gastrointestinal endoscopic mucosal biopsy revealed eosinophilic cell infiltration; therefore, the patient was diagnosed with EoG. Dupilumab administration was initiated for asthma, while improvement of secondary EoG was expected. Following dupilumab administration, both EoG and asthma symptoms, disease control, laboratory findings, endoscopic findings, and pathological findings improved. No adverse events have been reported after the dupilumab treatment.

Conclusion
This case report supports that dupilumab could be an effective treatment option for EoG and accompanying severe asthma.
Factor structures and psychometric properties of three brief versions of the difficulties in emotion regulation scale in the Korean population
Authors: Kim Gyumyoung , Yim Minkyung , Bae Hayoung , Hur Ji-Won 
Published: December 2024

Abstract
Background
This study examined the latent factor structures and psychometric properties of three brief versions of the Difficulties in Emotion Regulation Scale (DERS)—DERS-SF, DERS-18, and DERS-16—across large-scale samples of the Korean population.

Methods
Participants from two independent community samples (N = 862 and N = 1,242) completed an online self-report survey, including brief versions of the DERS and associated measures. Confirmatory factor analyses were employed to examine the latent factor structures of the brief versions of the DERS with comparable models. The internal consistency, concurrent validity, and convergent validity of the brief versions of the DERS were also assessed.

Results
The findings revealed that the bifactor models of the DERS-SF and DERS-18, excluding the Awareness subscale, showed superior fit indices for latent factor structure and favorable reliability. By contrast, the DERS-16 exhibited inadequate fit. Scores from the DERS-SF and DERS-18 demonstrated significant associations with indicators of psychological distress, supporting their convergent validity. The Awareness subscale showed lower internal consistency and distinctive correlation patterns with clinical outcomes.

Conclusions
These findings highlight the robustness of the DERS-SF and DERS-18 as parsimonious and efficient measures of emotion dysregulation with fewer items than the original version. Furthermore, this study provides additional support for excluding the Awareness subscale when using the brief versions of the DERS.
Glacial lakes inventory and susceptibility assessment in the Alsek River Basin, Yukon, Canada
Authors: Kroczek Tomáš , Vilímek Vít 
Published: December 2024

Abstract
Background
This study investigates glacial lake outburst floods (GLOFs) within the Alsek River Basin, Yukon, Canada, a region experiencing accelerated glacier retreat due to climate change. The formation and expansion of glacial lakes pose significant hazards to geomorphological and ecological systems, even in the absence of human infrastructure. Despite extensive research in other glaciated regions such as the Himalayas and Andes, the Canadian Cordillera remains understudied. This research aims to inventory glacial lakes and assess their susceptibility to GLOFs using remote sensing techniques and two distinct methodologies.

Results
A total of 590 glacial lakes were identified, with 57 in direct or indirect contact with glaciers, warranting a detailed susceptibility assessment. The study applied the glacier-focused methodology of Wang et al. (Mt Res Dev 31(2):122 (2011). https://doi.org/10.1659/mrd-journal-d-10-00059.1) and the lakespecific dynamics approach of Khadka et al. (Front Earth Sci 8(January):1–16 (2021). https://doi.org/10.3389/feart.2020.601288). Key findings include: High-Hazard Lakes: Lakes 22, 23, 133, 134, and 275 were consistently identified as high-hazard due to factors such as large glacier inputs, steep moraine dams, and rapid expansion rates. GLOF Events: Four GLOF events were confirmed between 2017 and 2019, with the most significant reducing Lake 21's area by over 80%. Comparative Analysis: The integration of both methodologies provided a comprehensive understanding, revealing complementary insights into glacier-driven and lake-specific GLOF triggers.

Conclusion
The results underscore the critical role of glacier retreat and lake dynamics in driving GLOF hazards in the Alsek
River Basin. The study highlights the importance of combining multiple assessment methodologies for robust hazard evaluation. Given the dynamic nature of glacial lakes and ongoing climate change, continuous monitoring and proactive hazard management strategies are essential to mitigate potential geomorphological and ecological impacts. This research contributes to the broader understanding of GLOFs in North America and underscores the need for similar assessments in other understudied glaciated regions.
A study for the genotoxicity assessment of substances containing probiotic candidates in the in vitro TK6 cell micronucleus test: Influence of low pH conditions and antibiotic supplementation on the test results
Authors: Fujiishi Yohei , Ohyama Wakako , Okada Emiko 
Published: December 2024

Abstract
Background
When assessing the genotoxicity of substances containing probiotic candidates, such as lactic acid-producing bacteria, using the in vitro micronucleus test (MNT), bacterial growth in the test medium may reduce the pH of the medium. The low medium pH is known to induce cytotoxicity and false-positive results. In the TK6 cell system, it is difficult to completely remove the bacteria from the medium by washing post-treatment, leading to bacterial growth during the recovery period in the short-term treatment. In the present study, the low pH range yielding false positives in the TK6 cell MNT was investigated using media supplemented with acetic, lactic, or formic acids, which are non-genotoxic bacterial metabolites. Additionally, to suppress the bacterial growth during the recovery period using antibiotics, i.e., penicillin/streptomycin (P/S), gentamicin sulfate (GM), and amphotericin B (AP), the maximum applicable concentrations of them that did not affect TK6 cell growth or micronucleus induction were determined. Then, we conducted an MNT using a substance containing live lactic acid-producing bacteria to verify the effectiveness of the antibiotics.

Results
Acetic, lactic, and formic acids induced micronuclei in TK6 cells (false positive) at an initial pH of ≤ 6.2 and ≤ 6.0 in 3 h treatment with and without S9 mix, respectively, and of ≤ 6.7 in the continuous treatment. Media supplemented with P/S, GM, and AP did not affect TK6 cell growth or micronucleated cell frequencies in the negative and positive controls ≤ 400 unit/mL-400 µg/mL, ≤ 250, and ≤ 20 µg/mL, respectively. In an MNT with fermented milk containing live lactic acid-producing bacteria, supplementation with P/S or GM to media for the recovery cultures suppressed the bacterial growth, decreasing pH, and cytotoxicity.

Conclusion
This study revealed the low pH ranges yielding false positives in the TK6 cell MNT under short-term and continuous treatment conditions. These values will serve as references for interpreting the biological relevance of results. Under short-term treatment, optimal antibiotic supplementation in recovery cultures suppressed bacterial growth in the test substance and prevented the decrease in pH that could yield false positives. This approach might be useful for evaluating the genotoxicity of test substances containing probiotic candidates using the MNT.
Family history at the crossroads: reflections on past, present, and future challenges
Authors: Reher David Sven 
Published: December 2024

AbstractThis paper contains the reflections of the author on the state of family history within the constellation of History and the Social Sciences. The first part of the paper presents a brief outline of how the discipline was founded and the elements in play that contributed to its enormous initial success, especially visible during the last three decades of the twentieth century. In recent years, however, there is some indication that research output on family history has been in decline and, more important, appears to have lost a significant part of the luster it once had. In the second part of this paper the author looks at the importance of promoting a past–present dialogue on the family and the way both historians and social scientists understand it. Ways of strengthening interactions between family history and family studies are discussed, as is the crucial importance for the discipline of the data revolution currently underway that for the first time offers massive information about families around the world over the past six decades. The author argues that both historians and social scientists have much to say about family life during this relatively recent past, albeit from very different perspectives. Studying family change constitutes a key challenge for the field. We discuss different ways of approaching this issue in the recent past, as well as the advisability of looking at the concept of family systems more closely. In societies or regions where earlier more historical data exist (normally in the more developed world), it may also be possible to link existing historical results to those from the census microdata era in order to provide a new, long-term perspective on family life spanning two centuries or even more. For social scientists and family historians alike, understanding the key dimensions of change and their implications for society constitute a crucial challenge for the discipline.
Stroboscopy evaluation of vocal folds lesions with pre and post phono surgery
Authors: Eldemerdash Ahmed Mohamed , Behiery Essam Abd Elwanees , Rashad Asmaa El-Dessouky , Elghazali Mohamed Elshahat Abdoh , Eldemerdash Ashraf Ali 
Published: December 2024

Abstract
Background
Video laryngostroboscopy (VLS) is the most used method to visualize vocal fold vibration and mucosal wave assessment. It is used to evaluate the pliability of the vocal fold mucosa and is an indication of the health and function of the mucosal tissue and deeper layers. The aim of this work was to study the role of VLS in the evaluation of vocal fold lesions for deciding the best management plan and achieving the best post-operative voice results.

Methods
This prospective observational study was carried out on 70 patients aged more than 12 years, both sexes, with vocal fold (VF) lesions namely benign vocal fold lesions. Minimal associated pathological lesions (MAPLS) include VF nodules, VF polyps, and VF cysts.

Results
There was no significant difference between the micro flap, excision, and truncation technique regarding any of the post-procedure VLS assessments of the patients with bilateral VF nodules and unilateral VF polyp (p > 0.05). There was no significant difference between the micro flap technique, excision technique, or marsupialization technique regarding any of the Post-procedure VLS assessments of the patients with unilateral VF cysts (p > 0.05).

Conclusions
VLS provides a better guide for the phono surgeon to delineate the plane of dissection micro laryngeal surgery (MLS) which helps him in preserving the functional mucosa of the VF. This helps in achieving good voice quality and outcome after surgery. No significant difference between different surgical techniques used for their excision.
Amitriptyline–perphenazine therapy for persistent idiopathic facial pain: translational perspectives from a retrospective study
Authors: Marchesini Maurizio , Topi Giulia , Bonezzi Cesare , Demartini Laura 
Published: December 2024

Abstract
Background
Persistent idiopathic facial pain (PIFP) can be challenging, both in its diagnosis, which appears to be purely exclusionary, and in its treatment, which currently lacks a gold standard. Amitriptyline is considered a first-line therapy, although not always effective. Recent insights into the role of dopamine in facial pain suggest that a novel therapeutic approach could target the dopamine system.

Methods
This study aimed to retrospectively evaluate the efficacy of treatment with amitriptyline–perphenazine association in patients with severe PIFP. Thirty-one patients were given a regimen dose of amitriptyline–perphenazine at dosages ranging between 10/2 and 20/4 mg and were then retrospectively analyzed. We evaluated the following outcomes, referred to the last week prior to follow-up visits: NRS score for pain intensity (minimum, maximum, and average), the number of attacks, and SF-36 questionnaire for quality of life. Comparisons were made between pre- and post-treatment.

Results
Thirty-one patients over 35 were screened. At baseline, average NRS was 5 ± 0.93 (CI 95%: 4.6–5.3), and the median number of breakthrough episodes over last week was 5 ± 1.57 (CI 95%: 4–6) with a maximum NRS = 9 ± 0.89 (CI 95%: 8–9). After treatment, average NRS was 4.1 ± 0.93 (CI 95%: 3.8–4.5; p < 0.001), maximum NRS was 6.1 ± 1.60 (CI 95%: 5.5–6.6), and the median number of attacks was 4 ± 0.99 (IC 95%: 3–4) (p < 0.001). Regarding SF-36 questionnaire, the most improved parameters were quality of life related to pain (25.89 ± 12.48 vs 31.19 ± 13.44; p < 0.001) and physical function (69.56 ± 17.84 vs 84.17 ± 20.99; p < 0.001).

Conclusion
Despite limitations, the pain scores, the frequency of the attacks, and quality of life were found to be significantly improved after treatment. Although results are not broad based given the small sample size, the combination of amitriptyline and perphenazine may be an effective and well-tolerated treatment in patients with PIFP. It is abundantly clear that dopaminergic pathways play a key role in pain modulation, yet the underlying mechanisms have not been fully understood, requiring further investigation.
Abemaciclib Plus Fulvestrant in Advanced Breast Cancer After Progression on CDK4/6 Inhibition: Results From the Phase III postMONARCH Trial
Authors: Kalinsky Kevin , Bianchini Giampaolo , Hamilton Erika , Graff Stephanie L. , Park Kyong Hwa , Jeselsohn Rinath , Demirci Umut , Martin Miguel , Layman Rachel M. , Hurvitz Sara A. , Sammons Sarah , Kaufman Peter A. , Muñoz Montserrat , Lai Jiun-I , Knoderer Holly , Sandoval Cynthia , Chawla Aarti R. , Nguyen Bastien , Zhou Yanhong , Ravenberg Elizabeth , Litchfield Lacey M. , Smyth Lillian , Wander Seth A. 
Published: December 2024

PURPOSE
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy (ET) are the standard first-line treatment for hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) advanced breast cancer (ABC); however, disease progression occurs in almost all patients and additional treatment options are needed. Herein, we report outcomes of the postMONARCH trial investigating a switch in ET with/without CDK4/6 inhibition with abemaciclib after disease progression on CDK4/6i.

METHODS
This double-blind, randomized phase III study enrolled patients with disease progression on previous CDK4/6i plus aromatase inhibitor as initial therapy for advanced disease or recurrence on/after adjuvant CDK4/6i + ET. Patients were randomly assigned (1:1) to abemaciclib + fulvestrant or placebo + fulvestrant. The primary end point was investigator-assessed progression-free survival (PFS). Secondary end points included PFS by blinded independent central review, objective response rate (ORR), and safety.

RESULTS

This study randomly assigned 368 patients (abemaciclib + fulvestrant, n = 182 placebo + fulvestrant, n = 186). At the primary analysis (258 events), the hazard ratio (HR) was 0.73 (95% CI, 0.57 to 0.95; nominal
P
= .017), with median PFS 6.0 (95% CI, 5.6 to 8.6) versus 5.3 (95% CI, 3.7 to 5.6) months and 6-month PFS rates of 50% and 37% in the abemaciclib + fulvestrant and placebo + fulvestrant arms, respectively. These results were supported by BICR-assessed PFS (HR, 0.55 [95% CI, 0.39 to 0.77]; nominal
P
< .001). A consistent treatment effect was seen across major clinical and genomic subgroups, including with/without
ESR1
or
PIK3CA
mutations. Among patients with measurable disease, investigator-assessed ORR was improved with abemaciclib + fulvestrant versus placebo + fulvestrant (17%
v
7%; nominal
P
= .015). No new safety signals were observed, with findings consistent with the known safety profile of abemaciclib.

CONCLUSION
Abemaciclib + fulvestrant significantly improved PFS after disease progression on previous CDK4/6i + ET in patients with HR+, HER2– ABC, offering an additional targeted therapy option for these patients.
Ecological Utopia and Dystopia in Chinese Science Fiction
Authors: Wang Ban 
Published: December 2024

Abstract
Crossing the binary of utopia and dystopia, this article reads Hao Jingfang's (1984–) novel Vagabonds as a critical ecotopia. I explore configurations of social worlds and eschew the politics of purity by highlighting the complexities of building a utopia while navigating entangled complicity and ambiguity between utopia and dystopia. The Mars Republic in the novel represents an ecotopia built through advanced technologies, where Martians adapt to the arid environment in contrast with the environmentally degraded earth. The novel portrays encounters, shocks, and mutual critiques between two planets. In general, the novel articulates the multicultural and multiracialism on Mars and the coming-of-age narrative of young Martians. Their self-realization rests on the assumption that humans must engage with and appropriate from nature while changing their inner nature.
Homozygous phytosterolemia and a literature review: A case report
Authors: Jiang Chun-Xin , Yang Guang , Shi Lian-Ping , Su Peng-Yu 
Published: December 2024

BACKGROUND
Phytosterolemia, also known as sitosterolemia, is a rare autosomal recessive disease characterized by elevated plasma plant sterol levels and xanthomata, which is easily misdiagnosed as familial hypercholesterolemia. Patients with homozygous phytosterolemia often have severe clinical manifestations, with xanthomata in childhood and premature atherosclerosis. Our patient had a milder clinical phenotype.
CASE SUMMARY
This report describes a patient with homozygous phytosterolemia who presented with only elevated cholesterol and low-density lipoprotein cholesterol (LDL-C) without xanthomata, arteriosclerosis, or hematological abnormalities. Homozygous mutation of ABCG5 which encodes an ATP-binding cassette transporter, was detected by whole exome sequencing and diagnosed as phytosterolemia. Measurement of the patient’s plasma plant sterol levels detected significant elevations in stigmasterol, rapeseed oil-derived plant sterol, and β-glutaminol levels. Ezetimibe was started and a low plant sterol diet was recommended. The patient’s blood lipid profile was reexamined one month later and showed significant decreases in total cholesterol and LDL-C levels. Phytosterolemia has similar clinical features as familial hypercholesterolemia, is highly susceptible to misdiagnosis, and has a very low incidence, and therefore clinicians need to consider a genetic diagnosis of a definitively hyperlipidemic disorder when statin drugs fail to lower lipid levels.
CONCLUSION
Phytosterolemia is easily misdiagnosed as familial hypercholesterolaemia and can be treated by dietary modification and cholesterol absorption inhibitors to lower blood lipids.
The Cuban state enterprise in its labyrinth: Conceptualisations, measures, and changes to be made
Authors: Rosales Humberto Blanco 
Published: December 2024

Abstract
The work assesses this economic actor in the programmatic documents of the last three Party Congresses. It starts with some data that characterise the Cuban entrepreneurial system at the end of 2023. After this, it very briefly looks at the document Economic and Social Guidelines of the Party and the Revolution (hereafter, Guidelines) that came out of the VI Party Congress, the foundational document of the so-called process of updating the Cuban economic model.
The next two sections open with a balance of the contributions and limitations of the Conceptualization of the Cuban Economic and Social Model of Socialist Development (hereafter Conceptualization) related to state-owned enterprises. Subsequently, other documents related to the ‘implementation’ of the Conceptualization are discussed. Finally it includes some ideas, the result of collective work, for transforming the management and the performance of this economic actor, in the midst of a critical situation that requires increasing the country’s entrepreneurial capacity, stabilising the macroeconomy, and embarking on the necessary and difficult path towards a productive reconstruction.