bluuebunny/crossref_metadata_2025_split huggingface dataset:
A SYSTEM APPROACH TO ASSESSING THE EFFECTIVENESS OF REGIONAL INNOVATION SYSTEMS IN THE CONCEPT OF STATISTICAL SUSTAINABILITY
Authors: Rashitovich Safiullin Marat , Valentinovich Chekhlomin Sergey , Vladimirovna Aksyanova Anna 
Published: December 2019

Purpose: The paper deals with the assessment and analysis of regional innovation systems. It is noted that the quantitative criterion of innovation effectiveness as the degree of influence of resources spent on obtaining the target result is practically not used in the analysis of the development of regional economic systems.
Methodology: The issues of quantitative measurement of the effectiveness, performance, and sustainability of the regional innovation system development are considered. According to the methodology proposed by the authors based on an assessment of the materiality and sustainability of statistical relationships between factor and result indicators of innovation activity, a multidimensional statistical analysis concerning the development of the Russian Federation regions by the level of innovative activity was carried out.
Result: The principle of division of the space formed by innovative activity features according to their functional significance in the system is formulated. A method of identifying sustainable relationships between elements of a regional innovation system within the process approach concept has been tested. Special groups of factors that have a statistically significant effect on innovation activity are identified. Methods for calculating effectiveness and performance indexes in categories of statistical variation are proposed. The differentiation of regions by the innovative development determinants is revealed. The conclusions about the feasibility of applying the presented methodology for a reliable assessment of the effectiveness of regional innovation system development are made.
Applications: This research can be used for universities, teachers, and students.
Novelty/Originality: In this research, the model of A system approach to assessing the effectiveness of regional innovation systems in the concept of statistical sustainability is presented in a comprehensive and complete manner.
TEGAS DESA TRADITION: MANIFESTATION OF LOCAL CULTURAL WISDOM OF AGRARIAN COMMUNITY IN NGASEM SRAGEN INDONESIA
Authors: Yuliani Saputri Ardian , Saddhono Kundharu , Sulaksono Djoko 
Published: December 2019

Purpose of the study: Tegas Desa tradition has been performed by the people of Ngasem Village for generations and is the heritage of the ancestors whose values ​​are still upheld. This study aims to describe the Tegas Desa tradition of Ngasem village agrarian community, identify Tegas Desa tradition as local cultural wisdom, describe ubarampe or offerings needed in performing the tradition, and explain the procession of the Tegas Desa tradition.
Methodology: This study is a qualitative descriptive study with an ethnographic approach. The data were sourced from the informants including the caretaker, village officials, and villagers. The data used were in the form of texts from interviews with informants, videos, photographs, relevant studies, and relevant books. The data were collected through observation, in-depth interviews, and document studies.
Main Findings: The results show that Tegas Desa tradition is a manifestation of gratitude for the rice yields of the agrarian community in Ngasem Village. The Ngasem Village community still believes in Javanese customs and culture whose values ​​are still upheld. Ubarampe or offerings use a lot of different types of foods. There are some differences or reductions in the implementation of the present tradition and the past.
Applications of this study: The implications of the study can be social capital in preserving a culture that can be used as a reinforcement of the nation's character through mutual cooperation, unity, and harmony among citizens. Tegas Desa tradition can be used as a local asset to get the support of the local government to preserve cultural heritage as a form of local cultural wisdom of the agrarian community.
Novelty/Originality of this study: There is no or has not been any study that discusses Tegas Desa tradition carried out by the agrarian community of Ngasem Village.
Geraghty Contractions in Ordered Uniform Spaces
Authors: Öztürk Vildan 
Published: December 2019

Banach
contraction principle is first and most
essential result in the fixed point theory. There are many generalisations of
this principle in the literature. One of them is Geraghty contraction. In this
work, Geraghty type contraction was defined via E-distance and common fixed
point theorems were proved for two mappings satisfying Geraghty type
contraction in ordered uniform spaces. Also, some results of these theorems were
obtained.
ANALISA PERFORMA TURBIN ANGIN SUMBU HORISONTAL BERSUDU AIRFOIL MELALUI VARIASI JUMLAH SUDU
Authors: Jhon Wabang A , Jufra Abanat D.J , Edwin Hattu 
Published: December 2019

Indonesia is an area that has the potential for sufficient wind resources to be utilized for kinetic energy into other energy such as mechanical energy and electrical energy through its generators (generators). The way to utilize wind kinetic energy into other energy is through a device called a wind turbine. Wind turbines have been around since ancient times, and are called airfoil angled wind turbines. This airfoil wind turbine is designed only for areas with average wind speeds above 6m / s. While in Indonesia not all regions have the same wind speed. In certain seasons, the average wind speed is below 6 m / s. This has become a major problem in regions that have average wind speeds below 6 m / s. Seeing this condition, there is a need for scientific research to obtain wind turbines that can be used in areas with average wind speeds below 5m / s. For this reason, the research I want to do is get a wind turbine that can be used as a power plant in areas that have wind speeds below 6m / s. This research was conducted on the basis of scientific theory in fluid mechanics regarding the sweeping area of wind turbines and the performance of variations in the number of blades in the wind. In addition, the research in several scientific journals was used as the basis of this research
This research method is an experimental method, in the form of testing a wind turbine axis prototype horizontal and airfoil axis. The details of the research activity are the design and manufacture of laboratory scale horizontal airfoil axis turbines. Next, testing with a fan as a source of wind. The fan used has three variations of speed, all of which are used to determine the lowest average wind speed that can be applied. The results of the research are where wind turbines with the greatest torque and power and the Coefficient of Performance (CP) with the highest value will be used as a result to be applied to the community. Based on experimental data, it can be concluded that the greatest torque and power occur in turbines with 4 blades with details at speed 1, the largest torque and power are 0.201 Nm and 4.5 W; at speed 2, the biggest torque and power are 0.25 Nm and 7.21 W; at speed 3, the biggest torque and power are 0.28 Nm and 8.35 W
Keywords: wind turbine, airfoil, nozzle, diffuser
OPTIMASI PARAMETER PEMESINAN WIRE ELECTRIC DISCHARGE MACHINING BAJA PERKAKAS SKD 11 MENGGUNAKAN METODE TAGUCHI
Authors: Okik Aris Setiawan , Dwi Djumhariyanto , Santoso Mulyadi 
Published: December 2019

EDM wire is one of the non-conventional machinings that is currently widely used in the manufacturing industry because it can process workpieces with hard material and also produces excellent dimensional accuracy. This research was carried out with variable current, voltage and wire speed processes. While the response variable is the material removal rate and cutting width (kerf), this study aims to determine the effect of each factor on each response as well as on the combined response and to find the right combination of parameters to produce optimal response values. The results of the study stated that the current strong factor contributed 89.84% and the wire speed factor was 8.26% against the cutting width response (kerf). The current strong element contributes 87.88% to the material removal rate response. As for the combined response, the influential factor was wire speed with a contribution of 92.79%. The optimal combination of parameters in the combined response is 7 amperes, 5 volts and 10 m / s wire speed. The conclusion of this study informs that the smaller the current strength, the better the value of the cutting width, while the more significant the current force will result in a higher removal rate material. The factor that influences the combined response is wire speed, where the increase in the value of the wire speed increases the amount of the Gray Relational Grade from the combined response.
Keywords: Wire EDM, SKD 11 Steel, Taguchi, Optimization
A New Mechanistic Model To Predict Boosting Pressure of Electrical Submersible Pumps Under High-Viscosity Fluid Flow with Validations by Experimental Data
Authors: Zhu Jianjun , Zhu Haiwen , Cao Guangqiang , Zhang Jiecheng , Peng Jianlin , Banjar Hattan , Zhang Hong-Quan 
Published: December 2019

Summary
As the second most widely used artificial-lift method in petroleum production (and first in accumulative production), electrical submersible pumps (ESPs) increase flow rates by converting kinetic energy to hydraulic pressure. ESPs are routinely characterized with water flow, and water performance curves are provided by the manufacturers (catalog curves) for designing ESP-based artificial-lift systems. However, the properties of hydrocarbon fluids are very different from those of water, especially the dynamic viscosities, which can significantly alter the ESP performance. Most of the existing methods to estimate ESP boosting pressure under high-viscosity fluid flow involve a strong empirical nature, and are derived by correlating experimental/field data with correction factors (e.g., Hydraulic Institute Standards 1955). A universally valid mechanistic model to calculate the ESP boosting pressure under viscous fluid flow is not yet available. In this paper, a new mechanistic model accounting for the viscosity effect of working fluids on ESP hydraulic performance is proposed, and it is validated with a large database collected from different types of ESPs.
The new model starts from the Euler equations for characterizing centrifugal pumps, and introduces a conceptual best-match flow rate QBM, at which the outlet flow direction of the impeller matches the designed flow direction. The mismatch of velocity triangles, resulting from the varying liquid-flow rates, is used to derive the recirculation losses. Other head losses caused by flow-direction change, friction, leakage flow, and other factors. are incorporated into the new model as well. QBM is obtained by matching the predicted H-Q performance curve of an ESP with the catalog curves. Once QBM is determined, the ESP hydraulic head under viscous-fluid-flow conditions can be calculated.
The specific speed (NS) of the studied ESPs in this paper ranges from 1,600 to 3,448, including one radial-type ESP and two mixed-type designs. The model-predicted ESP boosting pressure with water flow is found to match the catalog curves well if QBM is properly tuned. With high-viscosity fluid presence, the model predictions of ESP boosting pressure also agree well with the corresponding experimental data. For most calculation results within medium to high flow rates, the model prediction error is less than 15%. Unlike the empirical correlations that take experimental data points as inputs, the mechanistic model in this study does not require entering any experimental data, but can predict ESP boosting pressure under viscous fluid flow with a reasonable accuracy.
A Tangent-Line Approach for Effective Density Used in Ideal Mixing Rule: Part I—Prediction of Density for Heavy-Oil/Bitumen Associated Systems
Authors: Chen Zehua , Yang Daoyong 
Published: December 2019

SummaryAccurate prediction of density of an oil/gas mixture by using the ideal mixing (IM) rule is a great challenge, and its progress is still far from satisfactory. The method proposed by Standing and Katz (1942) for determining methane and ethane apparent densities is limited to only black oils and volatile oils. The methods recently proposed by Saryazdi (2012) and Saryazdi et al. (2013) to determine effective densities of methane through n-heptane (C1 through n-C7) and CO2 have shown some success, respectively, though limitations remain and the extent of their applications is still constrained. In this study, we developed a tangent-line approach for the effective density of C1 through n-C8, CO2, N2, toluene, cyclohexane, and dimethyl ether (DME). This method is more general and flexible than the extrapolation method proposed by Saryazdi (2012). A comprehensive database is established to first develop new correlations with one set of data and then compare them with the other. We successfully extended using the IM rule with effective density (IM-E) to condensate/bitumen systems, solvent/bitumen fraction systems, and solvent/bitumen systems with substantial extraction [i.e., emergence of a solvent-rich liquid phase (denoted as the L1 phase)] by properly treating the densities of condensate, bitumen fractions, extracts, and residues. This study focuses on heavy-oil/bitumen-associated systems, and the observed patterns and trends for different systems will be presented and explained in Part II of this study (Chen and Yang 2020).
An outbreak of norovirus-related acute gastroenteritis associated with delivery food in Guangzhou, southern China
Authors: Lu Ying , Ma Mengmeng , Wang Hui , Wang Dahu , Chen Chun , Jing Qinlong , Geng Jinmei , Li Tiegang , Zhang Zhoubin , Yang Zhicong 
Published: December 2019

Abstract
Background
A large number of students at a school located in Guangzhou city developed a sudden onset of symptoms of diarrhea and vomiting. In order to control the outbreak, an epidemiological investigation was conducted to determine the causative agent, sources, role of transmission and risk factors of the infections.
Methods
The study population consisted of probable cases and confirmed cases. An active search was conducted for cases among all students, teachers and other staff members. A case control study was carried out using online standardised questionnaires. Data were obtained regarding demographic characteristics, gastrointestinal symptoms, personal hygiene habits, history of contact with a person with diarrhea and/or vomiting and dining place in the past 3 days. Rectal swabs or stool samples of the cases, food handlers and environmental smear swab samples were collected to detect potential intestinal viruses and bacteria. Odds ratios (ORs) and 95% confidence intervals were calculated.
Results
A total of 157 individuals fit the definition of a probable case, including 46 with laboratory-confirmed norovirus infection between March 8 and March 22, 2018. The proportion of the students who had eaten delivery food three days before the onset of disease in the case group was 2.69 times that in the control group (95% CI: 1.88-3.85 ). Intake of take-out food three days before, exposure to similar cases 72 hours before onset and case in the same dormitory were risk factors. A total of 20 rectal swab samples from students, 10 rectal swabs from food handlers and 2 environmental swab samples of out-campus restaurant were tested positive for norovirus (G Ⅱ , genogroup Ⅱ strain ).
Conclusions
The outbreak of norovirus infectious diarrhea was determined. Food handling practices carries potential risk of acute gastroenteritis outbreaks due to a lack of surveillance and supervision. More attention should be paid to the monitoring and supervision of food handlers to reduce the incidence of norovirus-related acute gastroenteritis associated with delivery food.
Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure
Authors: Siebel Christian , Würthwein Gudrun , Lanvers-Kaminsky Claudia , André Nicolas , Berthold Frank , Castelli Ilaria , Chastagner Pascal , Doz François , English Martin , Escherich Gabriele , Frühwald Michael C. , Graf Norbert , Groll Andreas , Ruggiero Antonio , Hempel Georg , Boos Joachim 
Published: December 2019

Abstract
Background:
Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as treatment strategies vary and do not follow a clear pharmacological rationale. Standardisation of dosing strategies in particular for infants and younger children is required but is hampered by scarcely defined exposure-response relationships. The aim is to provide a rational dosing concept allowing for a reduction of variability in systemic therapy intensity and subsequently unforeseen side effects.
Methods:
Doxorubicin plasma concentrations in paediatric cancer patients were simulated for different treatment schedules using a population pharmacokinetic model which considers age-dependent differences in doxorubicin clearance. Overall drug exposure and peak concentrations were assessed. Simulation results were used to support a three round Delphi consensus procedure with the aim to clarify the pharmacological goals of doxorubicin dosing in young children. A group of 28 experts representing paediatric trial groups and clinical centres were invited to participate in this process.
Results:
Pharmacokinetic simulations illustrated the substantial differences in therapy intensity associated with current dosing strategies. Consensus among the panel members was obtained on a standardised a priori dose adaptation that individualises doxorubicin doses based on age and body surface area targeting uniform drug exposure across children treated with the same protocol. Further, a reduction of peak concentrations in very young children by prolonged infusion was recommended.
Conclusions:
An approach to standardise current dose modification schemes in young children is proposed. The consented concept takes individual pharmacokinetic characteristics into account and involves adaptation of both the dose and the infusion duration potentially improving the safety of doxorubicin administration.
Changes in serum albumin and other nutritional markers when using sucroferric oxyhydroxide as phosphorus binder among hemodialysis patients: a historical cohort study
Authors: Kalantar-Zadeh Kamyar , Ficociello Linda H , Parameswaran Vidhya , Athienites Nicolaos V. , Mullon Claudy , Kossmann Robert J. , Coyne Daniel W. 
Published: December 2019

Abstract
Background Elevated serum phosphorus concentrations are common among maintenance hemodialysis patients. Protein is a major source of dietary phosphate, but restriction of protein intake can result in hypoalbuminemia and protein-energy wasting. We hypothesized that sucroferric oxyhydroxide (SO), a potent phosphate binder with a low pill burden, may reduce serum phosphorus levels in hemodialysis patients with hypoalbuminemia without adversely impacting albumin levels or dietary intake of protein.Methods We retrospectively examined de-identified data from 79 adult, in-center hemodialysis patients with baseline hypoalbuminemia (≤ 3.5 g/dL) switched to SO as part of routine clinical care for at least 1 year. Temporal changes (3-month intervals from baseline through Q4) in phosphate binder pill burden, serum phosphorous levels, nutritional markers, and equilibrated Kt/V were analyzed. Data from a matched reference group of non-hypoalbuminemic patients ( N = 79) switched to SO were also examined.Results SO therapy was associated with a mean reduction of 45.7% and 45.1% in daily phosphate binder pill burden, and a mean reduction of 0.4 mg/dL and 0.51 mg/dL in serum phosphorus levels for the hypoalbuminemic and non-hypoalbuminemic patients, respectively. Hypoalbuminemic patients demonstrated significant increases in mean serum albumin levels from 3.50 mg/dL at baseline to 3.69, 3.74, 3.70, and 3.69 mg/dL during Q1 through Q4, respectively ( P < 0.0001), whereas serum albumin levels remained unchanged in the non-hypoalbuminemic group.Conclusions Both hypoalbuminemic and non-hypoalbuminemic patients switching to SO exhibited significant reductions in serum phosphorus concentrations and daily phosphate binder pill burden. Among hypoalbuminemic patients, the initiation of SO therapy was also associated with increases in serum albumin, suggesting therapy may have allowed patients to increase their dietary intake of protein.
Multiple chronic conditions and associated health care expenses in US adults with cancer: A 2010-2015 Medical Expenditure Panel Survey study
Authors: Davis-Ajami Mary Lynn , Lu Zhiqiang K , Wu Jun 
Published: December 2019

Abstract
Background: Cancer increases the risk of developing one or more chronic conditions, yet little research describes the associations between health care costs, utilization patterns, and chronic conditions in adults with cancer. The objective of this study was to examine the treated prevalence of chronic conditions and the association between chronic conditions and health care expenses in US adults with cancer. Methods: This retrospective observational study used US Medical Expenditure Panel Survey (MEPS) Household Component (2010-2015) data sampling adults diagnosed with cancer and one or more of 18 select chronic conditions. The measures used were treated prevalence of chronic conditions, and total and chronic condition-specific health expenses (per-person, per-year). Generalized linear models assessed chronic condition-specific expenses in adults with cancer vs. without cancer and the association of chronic conditions on total health expenses in adults with cancer, respectively, by controlling for demographic and health characteristics. Accounting for the complex survey design in MEPS, all data analyses and statistical procedures applied longitudinal weights for national estimates. Results: Among 3,657 eligible adults with cancer, 83.9% (n = 3,040; representing 16 million US individuals per-year) had at least one chronic condition, and 29.7% reported four or more conditions. Among those with cancer, hypertension (59.7%), hyperlipidemia (53.6%), arthritis (25.6%), diabetes (22.2%), and coronary artery disease (18.2%) were the five most prevalent chronic conditions. Chronic conditions accounted for 30% of total health expenses. Total health expenses were $6,388 higher for those with chronic conditions vs. those without (p<0.001). Health expenses associated with chronic conditions increased by 34% in adults with cancer vs. those without cancer after adjustment. Conclusions: In US adults with cancer, the treated prevalence of common chronic conditions was high and health expenses associated with chronic conditions were higher than those without cancer. A holistic treatment plan is needed to improve cost outcomes.