bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vasohibin-1 mediated tubulin detyrosination selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk
Authors: de Oliveira Marta Bastos , Katja Meier , Baptiste Coxam , Ilse Geudens , Simone Jung , Anna Szymborska , Holger Gerhardt 
Published: April 2020

ABSTRACTPrevious studies have shown that Vasohibin-1 (Vash-1) is stimulated by VEGFs in endothelial cells and that its overexpression interferes with angiogenesisin vivo. Recently, Vasohibin-1 was found to mediate tubulin detyrosination, a post-translational modification that is implicated in many cell functions, such as cell division. Here we used the zebrafish embryo to investigate the cellular and subcellular mechanisms of Vash-1 on endothelial microtubules during formation of the trunk vasculature. We show that microtubules within venous-derived secondary sprouts are strongly and selectively detyrosinated in comparison with other endothelial cells, and that this difference is lost uponvash-1knockdown. Vasohibin-1 depletion in zebrafish specifically affected secondary sprouting from the posterior cardinal vein, increasing both the number of sprouts and endothelial cell divisions. We show that altering secondary sprout numbers and structure uponvash-1depletion leads to a failure in the development and specification of lymphatic vessels of the zebrafish trunk.SUMMARYVasohibin-1 mediated detyrosination of endothelial microtubules is selectively required for adequate behaviour of venous secondary sprouting and subsequent formation of functional lymphatics in the zebrafish trunk.
The EccDNA Replicon: A Heritable, Extranuclear Vehicle That Enables Gene Amplification and Glyphosate Resistance in Amaranthus palmeri
Authors: Molin William T. , Yaguchi Allison , Blenner Mark , Saski Christopher A. 
Published: April 2020

Abstract
Gene copy number variation is a predominant mechanism used by organisms to respond to selective pressures from the environment. This often results in unbalanced structural variations that perpetuate as adaptations to sustain life. However, the underlying mechanisms that give rise to gene proliferation are poorly understood. Here, we show a unique result of genomic plasticity in Amaranthus palmeri: a massive, ~400-kb extrachromosomal circular DNA (eccDNA) that harbors the 5-ENOYLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE (EPSPS) gene and 58 other genes whose encoded functions traverse detoxification, replication, recombination, transposition, tethering, and transport. Gene expression analysis under glyphosate stress showed transcription of 41 of these 59 genes, with high expression of EPSPS, as well as genes coding for aminotransferases, zinc finger proteins, and several uncharacterized proteins. The genomic architecture of the eccDNA replicon is composed of a complex arrangement of repeat sequences and mobile genetic elements interspersed among arrays of clustered palindromes that may be crucial for stability, DNA duplication and tethering, and/or a means of nuclear integration of the adjacent and intervening sequences. Comparative analysis of orthologous genes in grain amaranth (Amaranthus hypochondriacus) and waterhemp (Amaranthus tuberculatus) suggests that higher order chromatin interactions contribute to the genomic origins of the A. palmeri eccDNA replicon structure.
Assessing resilience against floods with a system dynamics approach: a comparative study of two models
Authors: Feofilovs Maksims , Romagnoli Francesco , Gotangco Charlotte Kendra , Josol Jairus Carmela , Jardeleza Jean Meir Perez , Litam Joseph Emanuel , Campos Joaquin Ignacio , Abenojar Katrina 
Published: April 2020

Purpose
This paper aims to present the concepts of two different ways of generating a dynamic structure of the urban system to further allow in understanding specific urban behavior facing against flood and further evaluate the potential effect of specific resilience strategies aiming to decrease the exposure and vulnerability of the system.

Design/methodology/approach
Two system dynamics model structures are presented in form of Casual Loop Diagrams.

Findings
The main differences among the tow approaches are the time horizon and the approach that regulates the assessment of the resilience through a dynamic composite indicator: the first model refers to baseline at initial simulation time; the second model is focused on the ratio service supply to demand.

Research limitations/implications
Within the approach, the purpose is to properly and efficiently evaluate the effect of different Flood Risk Management strategies, i.e. prevention, defence, mitigation, preparation and recovery for consistent and resilient flood governance plans with different type of resilience scenarios.

Originality/value
The need for such tool is underlined by a lack on the assessment of urban resilience to flood as whole, considering the physical and social dimensions and the complex interaction among their main components. There are several assessment tools based on an indicator approach that have been proposed to meet this need. Nevertheless, indicator-based approach has the limitation to exclude the complexity of the system and its systemic interaction in terms of feedbacks’ effects among the identified components or variables selected for the system description. This peculiarity can be provided by System Dynamics modeling.
Supervisor support, work engagement and turnover intentions: evidence from Indian call centres
Authors: Pattnaik Subash Chandra , Panda Narendra 
Published: April 2020

PurposeThis paper aims to examine the relationship between supervisor support, work engagement and turnover intentions with work engagement playing the role of a mediator.Design/methodology/approachData from 386 Indian call centre employees through questionnaire survey was collected. A variety of statistical tools such as confirmatory factor analysis, Sobel test and descriptive statistics were used for examining the relationship.FindingsFrom this study, it was found that work engagement partially mediates the relationship between supervisor support and turnover intentions confirming well with the model hypothesized for the study.Originality/valueBoth employee turnover and disengagement levels in call centres keep on increasing, but very little research has been conducted so far on the linkage between supervisor support, work engagement and turnover intentions. Whatever little research has been conducted so far does not take supervisor support as a one-dimensional construct, thus obscuring its impact on work engagement and turnover intentions. That too, the findings about the relationship between work engagement and turnover intentions are mixed, thus calling for further studies. Moreover, the majority of the studies so far have come from Western contexts. The relationship is yet to be fully understood in the emerging Asian business context.
The influence of multi-stakeholder platforms on farmers' innovation and rural development in emerging economies: a systematic literature review
Authors: Barzola Iza Carlos L , Dentoni Domenico , Omta Onno S.W.F. 
Published: April 2020

PurposeDespite the increasing interest on multi-stakeholder platforms (MSPs) as novel organizational forms addressing grand challenges surrounding agri-food systems, the literature on how MSPs influence farmers' innovation remains scattered across sub-disciplines and geographies and, overall, of limited help for informing managerial and policy action and reflection.Design/methodology/approachTo address this gap, this systematic literature review (SRL) provides an overview on what MSPs are and how they influence farmers' innovation in emerging economies.FindingsThe selected sample included n = 44 publications in 2004–2018, focussing for 70% on Africa, with minor shares in Latin America and Asia, and with a strong theoretical and methodological segmentation across five sub-disciplines (agribusiness management, agricultural economics, agricultural innovation systems, agricultural research for development and public policy and governance). Overall, this SRL leads to three findings. First, a key distinctive organizational feature of MSPs relative to other novel organizational forms in emerging economies entails the presence of a virtual and/or physical interface spanning across multiple heterogeneous stakeholders. Second, in relation to their impact pathways towards farmers' innovation, MSPs tend to achieve different intermediary outcomes and levels of innovation depending on their organizational goals and activities.Research limitations/implicationsThese findings also reveal four key limitations of the extant MSP literature – namely, disciplinary silos thinking, linear thinking, limited focus on the role of informal institutions and little emphasis on power dynamics – which could inform managers and policy makers on how MSPs could influence farmers; innovation.Originality/valueThis study offers a SLR with the goal of providing practitioners and academics with first, a holistic view of the available research on the impact of MSPs on farmers innovation, and second, propose an impact pathway framework to understand how and under which circumstances MSPs support farmers' innovation given their functioning, structure and the governance mechanisms of MSPs.
Dealing with the visibility created by accounting numbers – A case study of cost accounting translation in a transitional economy
Authors: Albu Catalin Nicolae , Albu Nadia , Guinea Flavius Andrei , Tsamenyi Mathew 
Published: April 2020

PurposeThis paper investigates the process of translating a costing tool into operational use in the context of a transitional (post-communist) economy, where local institutions challenge the rationality of western methods.Design/methodology/approachBy mobilizing Actor–Network Theory, in particular Callon's four moments of translation, and by drawing data from an interventionist research, the paper focuses on the process of change instilled by the implementation of a costing tool in 20 Romanian construction companies.FindingsThe costing system is initially problematized as a tool for rational decision making. However, the visibility over the accounting figures generated by the costing tool instilled new roles for the cost system to manage internal and external interdependencies. First, two costing datasets were created, one for decision making and one for tax purposes, to manage the relationship with the state taxation authorities. Second, since the costing tool generated visibility over the field practices as well, engineers convinced management to drop the decision-making set of costs. The costing tool ultimately only became used for tax optimization, an originally unintended use, reflecting its translation process.Research limitations/implicationsBy taking an interventionist approach, the paper contributes to theorizing accounting in transitional economies by bringing their economic idiosyncrasies into the analysis.Practical implicationsThe results inform managers about the intended and unintended consequences of management accounting tools and about actors' role in shaping their use.Originality/valueOur research responds to recent calls to study how organizations configure their control systems in a rapidly changing environment and what is the role of management accounting in these arrangements.
Social Media use and value creation in the digital landscape: a dynamic-capabilities perspective
Authors: Garrido-Moreno Aurora , García-Morales Víctor , King Stephen , Lockett Nigel 
Published: April 2020

PurposeAlthough Social Media use has become all-pervasive, previous research has failed to explain how to use Social Media tools strategically to create business value in today's increasingly digital landscapes. Adopting a dynamic capabilities perspective, this paper empirically examines the specific process through which Social Media use translates into better performance and the capabilities involved in this process.Design/methodology/approachA research model is proposed that includes both antecedents and consequences of Social Media use. Existing research was examined to derive the research hypotheses, which were tested using SEM methodology on a sample of 212 hotels.FindingsThe results show that Social Media use does not exert significant direct impact on organizational performance. Rather, the findings confirm the mediating role played by Social CRM and Customer Engagement capabilities in the value creation process.Practical implicationsThe results demonstrate how Social Media tools should be implemented and managed to generate business value in hotels. Implications yield interesting insights for hotel managersOriginality/valueThis study is a first attempt to analyze empirically the real impact of digital media technologies, particularly Social Media use, drawing on the dynamic capabilities perspective and focusing on service firms (hotels). Including the variable “Organizational Readiness” as a basic prerequisite to benefit from Social Media use enhances the study's novelty and contribution.
Subcutaneous granuloma annulare on the heel: A case report and review of the Japanese published work
Authors: Endo Yukie , Sekiguchi Akiko , Motegi Sei‐ichiro , Ishikawa Osamu 
Published: April 2020

AbstractSubcutaneous granuloma annulare is a rare variant of granuloma annulare. It mostly presents as painless subcutaneous nodule(s) with or without annular lesions on the lower legs and scalp of children. We herein report a case of a 5‐year‐old Japanese girl with subcutaneous granuloma annulare on the right heel. The lesions improved in 15 months without any therapy. We also review 85 reported cases of subcutaneous granuloma annulare between 1 and 85 years of age in the Japanese published work. The most susceptible age was 5 years and below; however, a small peak occurred from the 40s to 60s. Subcutaneous granuloma annulare was more frequent in females (male : female ratio, 6:11). Sixty‐five cases (76.4%) had multiple lesions; the average number of lesions was 4.8 ± 5.8. The most affected site was the lower legs (28 cases), followed by the dorsum of the foot (21 cases) and scalp (17 cases). The heel was an unusual location; only two cases of sole subcutaneous granuloma annulare have been reported. Twenty‐one cases revealed a classical dermal change along with a subcutaneous change. Patients with classical dermal lesions were younger (P < 0.0001) and had a smaller number of lesions (P < 0.05) than those without the lesions. The lesion(s) resolved in 24 of the 44 untreated cases within 1 week to 19 months. Refractory or recurrent lesion(s) were seen in four of 21 treated cases and in four of 44 untreated cases. Because subcutaneous granuloma annulare lesions often resolve spontaneously without treatment, invasive treatments should be avoided.
Complex biotic interactions mediated by shrubs: Revisiting the stress‐gradient hypothesis and consequences for tree seedling survival
Authors: Guignabert Arthur , Augusto Laurent , Gonzalez Maya , Chipeaux Christophe , Delerue Florian 
Published: April 2020

Abstract

Using nurse shrubs to improve tree seedling establishment in stressed environments is a common practice in forestry. Recent refinements of the stress‐gradient hypothesis suggest that positive nurse effects occur under intermediate stress and decline in the harshest conditions. Additionally, indirect facilitation (e.g. protection from herbivory) is expected in low‐stressed/productive systems according to the initial stress‐gradient hypothesis. However, there have been fewer investigations into the use of nurse shrubs to decrease herbivore impacts in stressed systems compared with the role of nurses in stress alleviation. This raises the need to clarify conditions in which the use of nurse shrubs would be most appropriate.

We conducted a field experiment in the sand dune forest of southwest France characterized by severe summer water shortages and the presence of different types of wild herbivores. In 2015 and 2016, Pinus pinaster seedlings were planted under shrubs Arbutus unedo or in shrub‐removed locations, in fenced/unfenced areas. Survival, cause of mortality and water stress were monitored for 1 year after plantation.

Summer drought was the main cause of mortality. Water stress increased in both years as summer progressed. We found direct facilitation only in July 2016 at intermediate water stress, due to a decrease in vapour pressure deficit under shrubs. These positive effects declined in late summer when stress was at a maximum. Rodent damage occurred under shrubs in spring whereas ungulate browsing was observed in open areas in autumn/winter. Overall seedling survival was equivalent under or outside shrubs during the first year, but was better under shrubs in the second one.

Synthesis and applications. Our results partially validate the refinement of the stress‐gradient hypothesis, with a decline of positive interactions in the most water‐stressed conditions. This draws attention to the difficulty of using shrubs as nurses to improve tree regeneration in the most xeric systems. In addition, we show that indirect associational effects, both positive and negative, could be as important as abiotic stress alleviation in a stressful ecosystem, and using shrubs to facilitate seedling survival could be efficient depending on the type of herbivore involved. This highlights the fact that considering plant–plant interactions can help in the design of management options, providing that up‐to‐date ecological theories are considered and that the different biotic and abiotic constraints are accurately evaluated.
The Postcapitalist Transition: Policy Implications for the Left
Authors: Mason Paul 
Published: April 2020

AbstractThe postcapitalism thesis asserts that open source and collaborative non‐profit organisations represent a new, non‐market sector in which the profit motive and monetary exchange no longer drive economic activity; in Marxist political economy terms, they are a new means for suppressing the law of value. Information technology has produced four systemic dysfunctions, limiting capitalism’s ability to function as a complex adaptive system: the zero marginal cost effect, the tendency to delink work from wages, positive network effects, and information asymmetries. In response, in addition to the traditional remedies of social democracy for a stagnant neoliberal economic model, left parties must adopt a programme of transition: aggressively breaking up technological monopolies; promoting universal basic income and basic service solutions; outlawing rent‐seeking business models; and promoting data democracy.
Effects of entomopathogenic fungi on growth and nutrition in wheat grown on two calcareous soils: Influence of the fungus application method
Authors: González‐Guzmán Adrián , Sacristán Daniel , Quesada‐Moraga Enrique , Torrent José , del Campillo María Carmen , Sánchez‐Rodríguez Antonio Rafael 
Published: April 2020

AbstractEntomopathogenic fungi (EF) have so far aroused little interest as plant growth promoters or nutritional enhancers while protecting the plant against insect pests and mites. In this work, we examined the performance of Triticum durum and Triticum aestivum plants pot‐grown on two unsterilized Zn‐poor calcareous Vertisols and inoculated with Beauveria bassiana or Metarhizium brunneum by application to soil or seed dressing. The effects of fungal inoculation were found to depend on crop species, soil type, sampling time and fungus application method. While the height of the control plants tended to be significantly greater than the height of inoculated plants at early and intermediate growth stages, the trend changed at more advanced plant stage of development, 56 days after sowing (DAS). This was supported by the significant increase in aerial dry matter (ADM) in T. aestivum plants treated with B. bassiana by seed dressing (17.4%) or with M. brunneum with soil application and seed dressing (20.6 and 26.9%, respectively) 69 DAS. In T. durum, at harvest, seed dressing with B. bassiana or M. brunneum had an overall positive but not significant effect on ADM or grain yield, whereas direct application to the soil slightly decreased grain yield (6.6 and 5.5%, respectively) and ADM (5.3 and 6.1%, respectively). In T. aestivum, none of the fungus–application method combinations affected yield at harvest significantly. Fungal inoculation had little influence on nutrient uptake, whereas application to soil increased Mn uptake and grain Mn concentration in T. durum. Zinc uptake was significantly increased only in T. aestivum grown on the soil with the lowest Zn content treated with M. brunneum. Grain Zn concentration tended to be inversely related to grain yield. These results support seed dressing with EF as a promising green technology for sustainable crop protection and production with no adverse effects on plant performance.
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro‐inflammatory cytokines
Authors: Shang Dongsheng , Sun Danlin , Shi Chunyan , Xu Jun , Shen Mingxiang , Hu Xing , Liu Hanqing , Tu Zhigang 
Published: April 2020

AbstractIt is well established that inflammation in the body promotes organism aging, and recent studies have attributed a similar effect to senescent cells. Considering that certain pro‐inflammatory cytokines can induce cellular senescence, systematically evaluating the effects of pro‐inflammatory cytokines in cellular senescence is an important and urgent scientific problem, especially given the ongoing surge in aging human populations. Treating IMR90 cells and HUVECs with pro‐inflammatory cytokines identified six factors able to efficiently induce cellular senescence. Of these senescence‐inducing cytokines, the activity of five (namely IL‐1β, IL‐13, MCP‐2, MIP‐3α, and SDF‐1α) was significantly inhibited by treatment with cetuximab (an antibody targeting epidermal growth factor receptor [EGFR]), gefitinib (a small molecule inhibitor of EGFR), and EGFR knockdown. In addition, treatment with one of the senescence‐inducing cytokines, SDF‐1α, significantly increased the phosphorylation levels of EGFR, as well as Erk1/2. These results suggested that pro‐inflammatory cytokines induce cellular senescence by activating EGFR signaling. Next, we found that EGF treatment could also induce cellular senescence of IMR90 cells and HUVECs. Mechanically, EGF induced cellular senescence via excessive activation of Ras and the Ras‐BRaf‐Erk1/2 signaling axis. Moreover, EGFR activation induced IMR90 cells to secrete certain senescence‐associated secretory phenotype factors (IL‐8 and MMP‐3). In summary, we report that certain pro‐inflammatory cytokines induce cellular senescence through activation of the EGFR‐Ras signaling pathway. Our study thus offers new insight into a long‐ignored mechanism by which EGFR could regulate cellular senescence and suggests that growth signals themselves may catalyze aging under certain conditions.
Integration of whole‐genome DNA methylation data with RNA sequencing data to identify markers for bull fertility
Authors: Gross Nicole , Peñagaricano Francisco , Khatib Hasan 
Published: April 2020

SummaryPredicting bull fertility prior to breeding is a current challenge for the dairy industry. The use of molecular biomarkers has been previously assessed. However, the integration of this information has not been performed to extract biologically relevant markers. The goal of this study was to integrate DNA methylation data with previously published RNA‐sequencing results in order to identify candidate markers for sire fertility. A total of 1765 differentially methylated cytosines were found between high‐ and low‐fertility sires. Ten genes associated with 11 differentially methylated cytosines were found in a previous study of gene expression between high‐ and low‐fertility sires. Additionally, two of these genes code for proteins found exclusively in bull seminal plasma. Collectively, our results reveal 10 genes that could be used in the future as a panel for predicting bull fertility.