bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study of Dose Painting with IMRT Guided by Perfusion-weighted Magnetic Resonance Imaging for Brain Metastases
Authors: Hou Chuanke , Gong Guanzhong , Wang Lizhen , Su Ya , Lu Jie , Yin Yong 
Published: December 2020

Abstract
Purpose: To investigate dose escalation for brain metastases (BM) subvolumes with low cerebral blood flow (CBF) using dose-painting technology based on MR 3D arterial spin labeling (3D-ASL) images.Methods: A total of 50 patients with single BM were selected for this study. CT and MR simulation images, including contrast-enhanced T1-weighted (T1W) images and CBF images, were obtained. The gross tumor volume (GTV) was determined by fusion of contrast-enhanced CT and T1W images, and this volume was divided into high- and low-perfusion areas according to the difference in CBF. Sub-volume with less than 25% of the maximum CBF was defined as hypoxic region GTVH which was settled for dose escalation. The planning target volume (PTV) and PTVH were calculated from the GTV and the GTVH, respectively. The PTVN was calculated by subtracting the PTVH from the PTV. Plan 1 was defined as the conventional plan with a prescription dose of 60 Gy for the PTV. Plan 2 and Plan 3, respectively, escalated the prescription dose for the PTVH to 72 Gy with and without the maximum dose constrained based on Plan 1. Dosimetric indices were compared among the three plans.Results: On average, the GTV volume was 34.53 cm3, and the GTVH volume was 16.95 cm3, accounting for 49.09% of the GTV. Compared to Plan 1, the D2%, D98% and Dmean values of the PTVH escalated by 20.50%, 19.32%, and 19.60%, respectively, in Plan 2 and by 24.05%, 6.77%, and 17.00%, respectively, in Plan 3 (all P<0.05). The doses administered in Plans 2 and 3 were 73.67±0.34 Gy and 72.37±0.61 Gy, respectively (both P<0.05). In Plans 2 and 3, respectively, the conformity index of PTVH was increased by 45.45% and 63.64%; meanwhile, the homogeneity index was sacrificed, increasing from 0.04 to 0.05 and 0.11 (all P<0.05). Plan 2 achieved better values of D98% and Dmean, as well as a smaller increase in the homogeneity index, than Plan 3. The doses received by organs at risk (OARs) did not significantly differ between the conventional plans and the boost plans (all P >0.05).Conclusions: Targeted dose escalation guided by the 3D-ASL-based CBF differences in BM effectively escalated the dose delivered to low-CBF subvolumes without increasing the dose to OARs.
Phyto-Facilitated Bimetallic ZnFe2O4 Nanoparticles via Boswellia carteri: Synthesis, Characterization, and Anti-Cancer Activity
Authors: Imraish Amer , Al-Hunaiti Afnan , Abu-Thiab Tuqa , Ibrahim Abed Al-Qader , Hwaitat Eman , Omar Asma 
Published: December 2020

Background:
The growing dissatisfaction with the available traditional chemotherapeutic agents has
enhanced the need to develop new methods for obtaining materials with more effective and safe anti-cancer
properties. Over the past few years, the usage of metallic nanoparticles has been a target for researchers of
different scientific and commercial fields due to their tiny sizes, environment-friendly properties, and a wide
range of applications. To overcome the obstacles of traditional physical and chemical methods for the synthesis
of such nanoparticles, a new, less expensive, and eco-friendly method has been adopted using natural existing
organisms as a reducing agent to mediate the synthesis of the desired metallic nanoparticles from their
precursors, a process called green biosynthesis of nanoparticles.

Objective:
In the present study, zinc-iron bimetallic nanoparticles (ZnFe2O4) were synthesized via an aqueous
extract of Boswellia carteri resin mixed with zinc acetate and iron chloride precursors, and they were tested for
their anticancer activity.

Methods:
Various analytic methods were applied for the characterization of the phyto synthesized ZnFe2O4, and
they were tested for their anticancer activity against MDA-MB-231, K562, MCF-7 cancer cell lines, and normal
fibroblasts.

Results:
Our results demonstrate the synthesis of cubic structured bimetallic nanoparticles ZnFe2O4 with an
average diameter of 10.54 nm. MTT cytotoxicity assay demonstrates that our phyto-synthesized ZnFe2O4
nanoparticles exhibited a selective and potent anticancer activity against K562 and MDA-MB-231 cell lines with
IC50 values 4.53 μM and 4.19 μM, respectively.

Conclusion:
In conclusion, our biosynthesized ZnFe2O4 nanoparticles show a promising, environmentally
friendly, and low coast chemotherapeutic approach against selective cancers with a predicted low adverse side
effect toward normal cells. Further, in vivo, advanced animal research should be done to execute their
applicability in living organisms.
El archivo como obra total. Amancio Williams y la construcción de su memoria
Authors: Müller Luis 
Published: December 2020

<p class="p1">El Archivo Amancio Williams constituye un extraordinario recurso para la investigación, imprescindible para todo aquél que pretenda interpretar al arquitecto y su obra. A lo largo de toda su vida profesional, Amancio Williams reunió una formidable cantidad de información en dibujos, borradores, planos, documentos, cartas y otros materiales que representan la totalidad de su trabajo. La reciente donación del archivo completo al Canadian Centre for Architecture (CCA) abre nuevas perspectivas para ampliar y difundir su legado.<span class="Apple-converted-space"> </span></p>
Aspects Regarding the Online Modular Education System Compared with the Classical Onsite System
Authors: Bogdan Maria , Bucur Bogdan 
Published: December 2020

Abstract
In according with the situation created by the pandemics of the world [4,6,7,8,9,10], the Covid-19 viruses were affected the all fields of activity from the all domains, like as: industrial domains, tourism, commercial, even of the educational system at all levels [1,2]. In this context our university, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, it had to move from the classical educational system to approach of the new online modular system. This forced adaptation presents a lots of problems, especially of the all specializations within the Faculty of Engineering and Information Technology, where there are practical activities that involve laboratories with practical execution they cannot be performed by the online system. After an experience gained of almost 4 months of online activity, more several negative aspects are configured to be analyzed in order to find constructive solutions for optimizing the online educational system [1]. The present paper proposes to identification of a questionnaire addressed for the students as well as to the teachers from the Faculty of Engineering and Information Technology of UMFST “G.E.Palade” of Tg.Mures. Following the analysis of the all results of the questionnaire, the deficiencies of the problems raised by the technical disciplines that require phisicals practical applications in laboratory classes will be identified, respectively new directions for the development of modular online education will be identified representing the only alternative of the onsite classic education in this situation.
Effects of Long-Term Feeding of Treated Rapeseed Meal on Growth Performance, Blood Mineral Profile and Fatty Acid Composition of Back Fat in Pigs
Authors: Bujňák L. , Naď P. , Skalická M. , Marcinčák S. 
Published: December 2020

Abstract
This experiment was conducted to evaluate the effects of replacing soybean meal (SBM) with treated rape-seed meal (tRSM) on the growth performance, blood mineral levels and fatty acid composition of back fat in growing-finishing pigs. A total of 12 crossbred pigs (Slovakian White × Landrace) with an initial live weight of 40.82 ± 2.69 kg were divided into two dietary treatments. The experimental period lasted 84 days; 38 days in the growing period and 46 days in the finishing period. The dietary treatments were as follows: control, a SBM-based diet (growing and finishing), and experimental, a treated RSM-based diet (growing and finishing). The rapeseed meal was treated with a product that neutralizes the negative physiological effects of anti-nutritive glucosinolates contained in rapeseed products for livestock feeding. Our analysis showed minor, no significant negative effects of tRSM on live weight, average daily gain and feed conversion ratio. Replacing SBM with tRSM had no significant effects on the proportion of the total saturated, monounsaturated and polyunsaturated fatty acids of back fat samples, as well as concentrations of analysed serum minerals except zinc level. In conclusion, the inclusion of 25 % and 18 % of treated RSM in growing and finishing pig diets had no negative effects on the growth performance, blood mineral profile or fatty acid composition of back fat.
ADAPTATION OF DESIGNS FOR TEXTILE PRODUCTS INSPIRED FROM MADHUBANI PAINTING
Authors: Gupta Mohini , Gangwar Swati 
Published: December 2020

Madhubani art of the Bihar state has been undergoing transition where its application in original composition has been declined owing to social and economic changes now-a-days. There is need to explore possibilities for the conservation of this art form viz other artistic media for future generations. The reason for using traditional motifs in textiles is to keep our designs or motifs alive. The Indian folk arts with painting play important role in creating new designs. Escalating demands of consumers requires modification in the fashion industry with respect to design, colour, style and technique. So in an effort to add another dimension in the application of Madhubani designs on textiles, the present study was planned. The effort was targeted towards finding the possibility of applying Madhubani designs on textile articles utilizing the hand painting. Madhubani motifs/designs were adapted for center design and border design. Total thirty six motifs / designs were developed keeping in mind their suitability for articles like cushion cover, folder and table cloth. Developed design sheets were subjected to visual evaluation for selection of one best design in each category by the panel of thirty respondents to find out the suitability of the developed designs for hand painting. Finally three articles were prepared by using selected designs and these prepared articles were highly appreciated by the respondents.
„Bildung“ (Herder) und „Cultur“ (Adelung) im Vergleich
Authors: Laudin Gérard 
Published: December 2020

“Bildung” and “Kultur” are among the key terms of the German Enlightenment, and appear in various hierarchical forms in the late 18th century. In Adelung’s Versuch einer Geschichte der Cultur des menschlichen Geschlechts (1782), which partly draws on Herder’s Auch eine Philosophie der Geschichte zur Bildung der Menschheit (1774), the term Cultur refers to a social phenomenon that subsumes “refinement” (Verfeinerung), “Enlightenment” (Aufklärung) and “abilities” (Fähigkeiten). Adelung’s concept of culture is tightly linked to his interpretation of human history, which differs both from that of the largely politically oriented universal histories of his time, and from that of the anthropologically based “philosophies of history” (Iselin, Herder, Kant). For Adelung, culture is produced by “crowds in confined spaces” and thus appears as a quantitative phenomenon, as opposed to the qualitative elements such as power (Kraft) and fermentation (Gärung) that determine the course of history in Herder’s philosophy of history of 1774. Cultur emerges from a balance that comes about when the material and non-material components of a given culture are “in the most exact proportion” to each other. The idea of the “Maximum” formulated in Herder’s Ideen zur Philosophie der Geschichte der Menschheit (1784), which is described as “a climax” that every nation reaches in its own way, appears to be developed critically as a counterpart to Adelung’s concept of balance.
Maria Parrino, Alessandro Scarsella, Michela Vanon Alliata, M. (eds). Mary Shelley’s Frankenstein, 1818-2018
Authors: Canani Marco 
Published: December 2020

Review of Parrino, M.; Scarsella, A.; Vanon Alliata, M. (eds) (2020). Mary Shelley’s Frankenstein, 1818-2018. Newcastle upon Tyne: Cambridge Scholars Publishing, 256 pp.
Absceso de la glándula de bartolino
Authors: Delgado Fabiana 
Published: December 2020

Las glándulas de Bartolino, también conocidas como glándulas vestibulares mayores, son responsables de un gran número enfermedades ginecológicas de la vulva.; Los quistes y abscesos de la glándula de Bartolino pueden presentarse con síntomas diferentes y el manejo quirúrgico requerido debe ser marsupialización y no incisión y drenaje. Aunque se demostró que el procedimiento de incisión y drenaje es relativamente rápido y fácil de realizar y que la tasa de curación es rápida entre los pacientes que reciben este tipo de técnica quirúrgica, sin embargo se ha demostrado que la tendencia de recurrencias ha aumentado. Objetivo: realizar una revisión bibliográfica actualizada sobre el tema y su mejor manejo. Fuente de Datos: se realizó una búsqueda bibliográfica sistemática en la base de datos PubMed, Hinari y google académico desde el año 1985 al año 2020. Conclusiones: El mejor nivel de atención para las mujeres con quistes o abscesos de la glándula de Bartolino nunca podría lograrse sin la colaboración interprofesional.
Electro Optical Terahertz Pulse Reflectometry—A Fast and Highly Accurate Non-Destructive Fault Isolation Technique for 3D Flip Chip Packages
Authors: Barbeau Stephane , Alton Jesse , Igarashi Martin 
Published: December 2020

Abstract
Electro Optical Terahertz Pulse Reflectometry (EOTPR), a terahertz based Time Domain Reflectometry (TDR) technique, has been evaluated on Flip Chip (FC) and 3D packages. The reduced size and complexity of these new generations of advanced IC products necessitate non-destructive techniques with increased fault isolation accuracy. The minimum accuracy achievable with conventional TDR is approximately 1000μm. Here, we show that EOTPR is able to differentiate all of the critical features in a 3D FC package, such as μC4 and Through Silicon Via (TSV), and is capable of producing distance-to-defect accuracy of less than 20μm, a significant improvement over conventional microwave based TDR techniques.
Trojan Scanner: Detecting Hardware Trojans with Rapid SEM Imaging Combined with Image Processing and Machine Learning
Authors: Vashistha Nidish , Lu Hangwei , Shi Qihang , Rahman M Tanjidur , Shen Haoting , Woodard Damon L , Asadizanjani Navid , Tehranipoor Mark 
Published: December 2020

Abstract
Hardware Trojans are malicious changes to the design of integrated circuits (ICs) at different stages of the design and fabrication processes. Different approaches have been developed to detect Trojans namely non-destructive (electrical tests like run-time monitoring, functional and structural tests) and destructive (full chip reverse engineering). However, these methods cannot detect all types of Trojans and they suffer from a number of disadvantages such as slow speed of detection and lack of confidence in detecting all types of Trojans. Majority of hardware Trojans implemented in an IC will leave a footprint at the doping (active) layer. In this paper, we introduce a new version of our previously developed “Trojan Scanner” [1] framework for the untrusted foundry threat model, where a trusted GDSII layout (golden layout) is available. Advanced computer vision algorithms in combination with the supervised machine-learning model are used to classify different features of the golden layout and SEM images from an IC under authentication, as a unique descriptor for each type of gates. These descriptors are compared with each other to detect any subtle changes on the active region, which can raise the flag for the existence of a potential hardware Trojan. The descriptors can differentiate variation due to fabrication process, defects, and common SEM image distortions to rule out the possibility of false detection. Our results demonstrate that Trojan Scanner is more reliable than electrical testing and faster than full chip reverse engineering. Trojan Scanner does not rely on the functionality of the circuit rather focuses on the real physical structure to detect malicious changes inserted by the untrusted foundry.
In-House Transistors’ Layer Reverse Engineering Characterization of a 45nm SoC
Authors: Courbon Dr. Franck 
Published: December 2020

Abstract
Reverse engineering typically requires expensive equipment, skilled technicians, time, a cross section of the component to be sliced out, and a dedicated reconstruction software. In this paper, we present a low-cost alternative, combining fast frontside sample preparation, electron microscopy imaging, similar standard cell recognition, as well as within and between die Standard Cell Statistical Analysis (SCSA). We develop the process to access the transistor’s drain/source area; image the full surface; develop a robust pattern recognition tool and analyze the standard cell size, local / global location and occurrences number. We present the inner workings of each step and results on 45–65nm FCBGA devices enabling to locate specific areas (core registers, hardware accelerator, and so on) within a die, and find similarities between dies. We particularly point out the importance of such design information extraction for local fault injection and hardware assurance. The primary goal is to analyze how much integrated circuit design information can be retrieved with minimal costs and without outsourcing.
DEVLET OKULLARI VE ÖZEL OKULLARDAKİ MÜZİK EĞİTİMİ UYGULAMALARINA İLİŞKİN BİR DEĞERLENDİRME
Authors: GÜL Gülnihal , KALE Merve Nur 
Published: December 2020

Bu araştırmada devlet okulu ve özel okullarda müzik. Araştırmanın çalışma grubunu kolay ulaşılabilir örneklem yöntemiyle belirlenmiş 10 müzik öğretmeni oluşturmaktadır. Çalışma grubuna açık uçlu 7 sorudan oluşan görüşme formu ve 4 soruluk demografik bilgi formu uygulanmıştır. Görüşmeler sonucunda elde edilen verilerin çözümlenmesinde betimsel analiz tekniğinden yararlanılmıştır. Bu çalışmadan elde edilen bulgular doğrultusunda devlet okullarında görev yapan müzik öğretmenlerinin ders yüklerinin az olduğu; özel okullarda görev yapan öğretmenlerin ise yoğun bir ders yükü ve iş yükü ile stres altında çalıştıkları, anaokulundan liseye kadar tüm kademelerde müzik derslerini gerçekleştirdikleri tespit edilmiştir. Ayrıca özel okul öğretmenlerin çalıştıkları kurumların fiziki ve maddi koşullarının yeterli olduğu yönünde; devlet okullarında görev yapan öğretmenlerin ise çalıştıkları kurumların fiziki ve maddi koşullarının yeterli olmadığı yönünde görüş bildirdikleri belirlenmiştir.Bu makale için 30-06-2021 tarihinde bir düzeltme yayınlandı. https://dergipark.org.tr/tr/pub/ejmd/issue/63535/963363
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS REALISTIC MATHEMATICS EDUCATION MENGGUNAKAN APLIKASI MACROMEDIA FLASH PADA MATERI SPLDV
Authors: Susanti Yuni , Friansah Drajat , Elly S As 
Published: December 2020

Penelitian ini bertujuan mengembangkan media pembelajaran matematika berbasis realistic mathematics education yang valid dan praktis menggunakan aplikasi macromedia flash pada materi sistem persamaan linier dua variabel di kelas VIII SMP Negeri 01 Lubuklinggau dan mengetahui karakteristik media pembelajaran macromedia flash yang dikembangkan. Penelitian ini menggunakan model ADDIE yang terdiri dari 5 tahap yaitu: Analyze, Design, Development, Implementation, dan Evaluation. Berdasarkan hasil validasi oleh tiga ahli yaitu: ahli bahasa, ahli materi dua validator, dan ahli media pembelajaran macromedia flashÂ memenuhi kriteria valid dengan rata-rata skor 4,14. Sedangkan hasil analisis penilaian angket kepraktisan diperoleh bahwa media pembelajaran macromedia flash memenuhi kriteria praktis dengan rata-rata skor 4,08. Karakteristik yang dihasilkan dalam pengembangan media pembelajaran macromedia flash adalah materi sesuai kompetensi yang ingin dicapai, konsep materi yang disajikan benar dan berfokus pada keterkaitan antar disiplin, terdapat petunjuk yang jelas, terdapat apersepsi, alur pembelajaran jelas, terdapat pertanyaan masalah untuk diselesaikan siswa, kesimpulan setiap sub materi, latihan dan pembahasannya, serta soal evaluasi, penyelidikan autentik dan interaktif, bersifat mandiri dan menghasilkan karya dan memamerkannya, navigasi mudah, urutan terkendali, bahasa mudah dipahami siswa, gambar, animasi, teks, dan warna tersaji secara serasi dan harmonis, dan berkolaborasi.
Food Safety on the Farm: Good Agricultural Practices and Good Handling Practices – Packing Operation Sanitation
Authors: Lepper Jesscia A. , Sreedharan Aswathy , Goodrich Schneider Renée , Schneider Keith R. 
Published: December 2020

Good agricultural practices (GAPs) and good handling practices (GHPs) encompass the general procedures that growers, packers and processors of fresh fruits and vegetables should follow to ensure the safety of their product. GAPs usually deal with preharvest practices (i.e., in the field), while GHPs cover postharvest practices, including packing, storage and shipping. This factsheet covers GAPs relating to packing operation sanitation. There are seven other Florida Cooperative Extension factsheets in the ‘Food Safety on the Farm’ series that focus on specific aspects of the GAPs program and how they relate to Florida crops and practices.
Under the new Food Safety Modernization Act (FSMA), GAPs are a foundation of the Produce Safety Rule (PSR). Other than for round tomatoes in Florida (T-GAPs regulation), GAPs have mainly been a voluntary program. Additionally the PSR mandates all non-exempt operations to follow these new FSMA federal guidelines (6), but all exempt commodities and for those producers exporting to foreign countries, GAPs may still be required. Both the mandatory PSR and GAPs aim to reduce the foodborne illness burden associated with produce.
Türkiye’de “Tele Çalışma” Üzerine Sosyolojik Bir Değerlendirme: Gölge Çalışanlar
Authors: GÖNÜLLÜ Canan 
Published: December 2020

Gelişen teknoloji ve dönüşen dünya ile birlikte çalışma şartları ve koşullarında da çeşitli değişiklikler göze çarpmaktadır. Üretim ilişki ve biçimlerinin değişmesi, tarihsel süreç içinde çalışmanın niteliğini değiştirirken, bilişim teknolojilerinde ve üretim araçlarında meydana gelen değişim ve dönüşümler de klasik çalışma yöntem ve biçimleri üzerinde birtakım etkilere ve değişimlere sebep olmuştur ve olmaya devam etmektedir.
Günümüz bilgi toplumlarında, üretimin kas gücünün ötesine geçmesiyle birlikte tele-çalışma adı verilen çalışma biçimi de gündeme gelmiştir ve görülme sıklığı giderek artmaktadır. Çalışanların zaman ve mekândan bağımsız olarak çalışmasına imkân veren bu anlayış, toplumsal birtakım tartışmaları da beraberinde getirmektedir.
Bu çalışmada yaygınlığı giderek artmakta olan çalışma biçimlerinden tele çalışmanın, çalışanlar üzerindeki etkileri çok yönlü olarak incelenmiştir. Bu çalışma biçiminin bireysel ve toplumsal yansımaları sosyolojik bir perspektifle ele alınmıştır. Nitel olarak tasarlanan bu çalışmada, tele çalışma biçimiyle çalışma yaşantısında yer alan kişilerle derinlemesine mülakatlar yapılmıştır. Görüşülenlerin seçilmesi amaçlı örnekleme biçimlerinden olan kartopu örneklemesi ile gerçekleştirilmiştir. Verilerin çözümlenmesi için içerik analizi tekniğinden faydalanılmıştır. Çalışma sonundaki bulgular, bu yeni çalışma biçiminin toplumda kabul görmesinin, sürece yayılması gerektiği ile paralellik göstermektedir. Ayrıca bu çalışma biçiminde sosyal bir varlık olarak insanın sosyal yönünün, çalışan olarak dikkate alınması gerektiği sonucuna ulaşılmıştır.