bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the Dynamic Compensation Method of the Shock Wave's Evaluation Pressure Sensor
Authors: Wang Wei 
Published: September 2020

Abstract
Due to the steep and changing fast rising edge of explosion shock wave signal, it asks for good dynamic characteristic of sensor and test system. As far as the development of the sensor level, they are difficult to achieve dynamic characteristic requirement of approximate distortionless transmission, so cause a large dynamic error in the actual test. This paper, aiming at providing theoretical support for technology guarantee and service of the shock wave testing system of national shooting range, conducts a research on the method of dynamic characteristic compensation of pressure sensor facing the power evaluation of the blast shock wave. The research proposes and studies the filter design method of dynamic compensation of pressure sensor based on PFQPSO (the progressive function quantum-behaved particle swarm optimization) algorithm, which belongs to inverse modeling. The dynamic compensation can be realized without knowing the model of sensor, so the extra error caused by dynamic modeling of sensors can be avoided. using 8510 series sensor can be used with lower natural frequency and lower measurement range from Endevco Company, this research has had experiment and modeling on the dynamic characteristics of shock tubes as well as design of dynamic compensation filter. Based on the analysis and confirmation, this study illustrates the possibility and effectiveness of this method.
Symptomatology of Coronavirus Disease 2019 (COVID-19) - Lessons from a meta-analysis across 13 countries
Authors: Gamakaranage Champika Saman Kumara , Hettiarachchi Dineshani , Ediriweera Dileepa , Jayasinghe Saroj 
Published: September 2020

Abstract
Background: COVID-19 pandemic has resulted in varying clinical manifestations and mortality rates. There is no consensus on the symptomatology that would guide researchers and clinicians. Objective: The objective was to identify symptoms and their frequencies of COVID-19 with a meta-analysis of studies from several countries. Data sources: A systematic review using PubMed and Google Scholar data sources and reference tracing were used to identify 7176 articles. Eligibility criteria: Suitable articles were selected manually with selection criteria and 14 original articles included in meta-analysis. Data abstraction and analysis: PRISMA guidelines, used for data abstraction and a table was generated by feeding it with numbers and proportions of each symptom described. A meta-analysis was carried out using random effect models on each symptom separately across the studies and their prevalence rates and 95% confident intervals were calculated.Results: Selected 14 studies, either cross-sectional or cohort studies are analyzed. There were 2,660 confirmed cases of COVID-19. The majority were from China (n=2,439, 91.7%) and remainder from the Netherlands, Italy, Korea and India and one article from Europe. There was a total of 32 symptoms identified from the meta-analysis and additional 7 symptoms were identified from reference searching. The most common symptoms were (prevalence >50%): fever (79.56%, 95% CI: 72.17-86.09%), malaise (63.3%, 95% CI: 53.1 – 73.0%), cough (56.7. %, 95% CI: 48.6 - 64.6 %) and cold (55.6%, 95% CI: 45.2 – 65.7%). Symptoms of intermediate incidence (5-49%) were; anosmia, sneezing, ocular pain, fatigue, sputum production, arthralgia, tachypnea, palpitation, headache, chest tightness, shortness of breath, chills, myalgia, sore throat, anorexia, weakness, diarrhea, rhinorrhea, dizziness, nausea, altered level of consciousness, vomiting and abdominal pain. Rare symptoms (<5%): tonsil swelling, haemoptysis, conjunctival injection, lymphadenopathy and rash. Conclusion and implications of key findings: We found (25/32, from meta-analysis) symptoms to be present in =>5% of cases which could be considered as “typical” symptoms of COVID-19. The list of symptoms we identified is different from those documents released by the WHO, CDC, NHS, Chinese CDC, Institute Pasteur and Mayo Clinic. The compiled list would be useful for future researchers to document a comprehensive picture of the illness.
Expectant management of pneumothorax in intubated COVID 19 positive patients: A case series
Authors: Elder Colby , Bawa Sheina , Anderson Douglas , Atkinson Stephen , Etzel Joshua , Moritz Troy 
Published: September 2020

Abstract
Background: There is an increasing amount of literature describing the pathogenesis of coronavirus disease 2019 (COVID-19) pneumonia and its associated complications. Historically, a small pneumothorax has been shown to be successfully treated without chest tube insertion, but this management has yet to be proven in COVID-19 pneumonia patients. In addition, pneumothorax in an intubated patient with high positive end-expiratory pressure (PEEP) provides additional uncertainty with pursuing non-operative management. Case Presentation: In this series we report four cases of patients with respiratory distress who tested positive for COVID-19 via nasopharyngeal swab and developed ventilator-induced pneumothoraces which were successfully managed with observation alone.Conclusions: Management of patients with COVID-19 pneumonia on positive pressure ventilation who develop small stable pneumothoraces can be safely observed without chest tube insertion.
In Vitro, Evaluation of Anticancer and Anti-dermatophytes Activities of Some Egyptian Medicinal Plants&nbsp;
Authors: El-Bondkly Esraa Ahmed Mohamed , El-Gendy Mervat Morsy , El-Bondkly Aya Ahmed Mohamed , El-Shenawy Fareed Shawky , El-Bondkly Alaa Ahmed Mohamed 
Published: September 2020

Abstract
In this investigation three ancient Egyptian medical plants; Plantago albicans L., Thymelaea hirsuta (L.) Endl. and Urginea maritima (L.) were chosen to explore their biochemical properties, anticancer and antimycotic activities against clinical dermatophytes. Growing of Trichophyton soudanense, Trichophyton erinacei, Microsporum audouinii, Microsporum gypseum, Microsporum gallinae, Microsporum ferrogenium, Microsporum cookie, Microsporum racemosum, Microsporum persicolor and Microsporum canis were totally inhibited by the 100 µg/mL of P. albicans methanolic extract. Whereas the growth of T. soudanense, T. erinacei, Trichophyton rubrum, Trichophyton tonsurance and Trichophyton mentagrophytes and Epidermophyton floccosum were 100% inhibited by the methanolic extract of T. hirsiuta at 100 µg/mL concentration, however its acetone extract was more active against Microsporum species. The highest fungi toxicity against all dermatophytic fungi was detected in both methanol and acetone extract of U. maritima at a concentration ranged between 50 to 100 µg/mL. Methanolic extract of P. albicans inhibited the viability of HCT-116, HepG-2, MCF-7 and HeLa cell lines by (41%, 40%, 80% and 81%); (30%, 20%, 66% and 70%); (19%, 0%, 49% and 57%); (5%, 0%, 35% and 45%) and (0%, 0%, 21% and 40%) at 25, 50, 100, 200 and 300 µg/mL, respectively. Moreover, the cells death after treatment with the same concentrations of T. hirsuta methanol extract were (10%, 20%, 23% and 60%); (16%, 40%, 58% and 80%); (40%, 50%, 80% and 100%); (51%, 65%, 100% and 100%) and (49%, 82%, 100% and 100%) in HCT-116, HepG-2, MCF-7 and HeLa cells, respectively. Viability of HCT-116, MCF-7 and HepG-2 cell lines was totally suppressed with 100 µg/mL whereas the HeLa cell growth was reduced to 10% and totally killed at 100 and 200 µg/mL, respectively of U. maritima methanolic extract. All data approve the significance of Egyptian ethnomedical plants as potent source of diverse bioactive pharmaceutical metabolites.
Texture indices of 4′-[methyl-11C]-thiothymidine uptake predict p16 status in patients with newly diagnosed oropharyngeal squamous cell carcinoma: Comparison with 18F-FDG uptake
Authors: Ihara-Nishishita Ayumi , Norikane Takashi , Mitamura Katsuya , Yamamoto Yuka , Fujimoto Kengo , Takami Yasukage , Ibuki Emi , Kudomi Nobuyuki , Hoshikawa Hiroshi , Toyohara Jun , Nishiyama Yoshihiro 
Published: September 2020

Abstract
Background: In oropharyngeal squamous cell carcinoma (OPSCC), human papillomavirus (HPV)/p16 status is important as a prognostic biomarker. Purpose: We evaluated the relationship between 4¢-[methyl-11C]thiothymidine (11C-4DST) and 18F-FDG PET texture indices and p16 status in patients with newly diagnosed OPSCC. Methods: We retrospectively reviewed the collected data of 256 consecutive, previously untreated patients with primary head and neck tumors enrolled between November 2011 and October 2019. Complete data on both 11C-4DST and 18F-FDG PET/CT studies before therapy, patients with OPSCC, and p16 status were available for 34 patients. Six of them were excluded because they did not exhibit sufficient 11C-4DST and/or 18F-FDG tumor uptake to perform textural analysis. Finally, 28 patients with newly diagnosed OPSCC were investigated. The maximum standardized uptake value (SUVmax) and 6 texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low-gray-level-zone emphasis, and high-gray-level-zone emphasis) were derived from PET images. The presence of p16 expression in tumor specimens was examined by immunohistochemistry and compared with the PET parameters. Results: Using 11C-4DST, the expression of p16 was associated with a higher homogeneity (P = 0.012), lower short-run emphasis (P = 0.005), higher long-run emphasis (P = 0.009), and lower high-gray-level-zone emphasis (P = 0.042) values. There was no significant difference between 18F-FDG PET parameters and p16 status. Conclusion: Texture indices of the primary tumor on 11C-4DST PET, but not 18F-FDG PET, may be of value in predicting the condition’s p16 status in patients with newly diagnosed OPSCC.
Investigation of The Optimal Surgical Approach to Brucella Lumbar Spondylitis Treatment: A Comparative Study
Authors: Jia Chenguang , Gao Jianguo , Li Zhuo , Dong Zhaoliang , Yao Liming , Wang Lianbo , Yao Xiaowei 
Published: September 2020

Abstract
Background: The optimal surgical approach in treating lumbar brucellosis (LBS) has not been determined. This study aims to compare the surgical efficacy of anterior approach and combined posterior and anterior approach in treating LBS.Method: A retrospectively cohort study included LBS patients undergoing lumber surgery in the Department of Orthopedics, Department of Orthopedics, Hebei Province from June 2012 to June 2016. According surgical approach, patients were divided into two groups; patients with one-stage anterior approach were classified into group A, and the rest of patients with combined posterior and anterior approach were group B. The operative time, intraoperative blood loss and, hospitalization stay were recorded to compare the surgical risk of two groups. In terms of treatment efficacy, visual analogue scale (VAS), bone graft fusion, erythrocyte sedimentation rate (ESR) and Oswestry disability index (ODI) were assessed and compared before and after surgery.Results: Eight-nine patients with LBS were included into the study. Fifty cases were males, and 39 patients were female. The mean age of this cohort was 61.9 ± 12 years, ranging from 23 to 78 years. Forty-nine patients were divided into group A, undergoing anterior debridement and bone graft fusion. Forty patients underwent posterior fixation combined with anterior approach (group B). The operation time of group A was 30 minutes shorter than that of group B. Group A had less intraoperative blood loss (800 vs. 900 ml; P <0.001). Hospital stay was four days shorter in group A. At the last follow-up, all patients were in good condition with ASIA Level E and ESR returned to normal. The bone fusion rate of Bridwell bone was 89.29% (45/49) and 80.00% (38/40) of group A and group B, respectively. In terms of surgical efficacy, there was no significant difference in VAS score between the two groups before and after operation (P > 0.05). Conclusions: One-stage anterior approach and combine posterior-anterior approach had no significant difference in terms of clinical efficacy. Individualized surgical treatment should be suggested in patients with complicated LBS and ineffective therapeutic treatment. Trial registration: This study has been retrospectively registered in local ethical Institution Review Board(No:[2020]068).
Prognostic and Predictive Values of the Autophagy Signature in Colon Cancer
Authors: Xu Qian , Guo Yugang , Fang Jintao , Zhou Jiawei , Ma Guohui , Heng You 
Published: September 2020

Abstract
Background: In the clinical decision-making among patients with colon cancer (COAD), making an accurate prognosis of the patients plays a central role. The effects of autophagy on the clinical outcomes of cancer, including COAD, have been widely reported in numerous studies. Here, weaim to build a novel autophagy-associated, risk-stratification scoring system to predict the overall survival(OS)of patients with COAD. Methods: In this study, the candidate autophagy-related prognostic genes correlated with the survival of COAD patients from The Cancer Genome Atlas (TCGA) public RNA microarray and clinical data sets were selected as training data set. A cohort of 67 patients from TCGA and a cohort of 124 patients from GEO were used for the external validation. The autophagy-related mRNAs(ARGs) were analyzed by multivariate Cox regression analyses. Spearman correlation analysis were used to construct autophagy-related mRNAs and lncRNAs coexpression network. Results: 6 autophagy-related mRNAs and 14 lncRNAs with prognostic value were extracted for constructing two novel autophagy-related RNAs signatures, respectively. Univariate and multivariate Cox regression analyses were then demonstrated that the two signature could act as independent prognostic predictor for OS. Additionally, a prognostic nomogram incorporating the clinicopathological characteristics(patient’s age, tumor stage) and autophagy-related lncRNA risk score was constructed to predict the OS, which was used in the training and validation sets (5-year C-index: 0.826 and 0.895, respectively), demonstrating better discrimination ability and clinical net benefit than the risk score model. Further gene set enrichment analysis revealed that autophagy-associated lncRNAs were significantly enriched in cancer-related pathways.Conclusions: The identified autophagy-related mRNAs and lncRNAs signature had important clinical implications in prognosis prediction and the user-friendly nomogram may offer an extra insight for individualized therapy of COAD.
Effectivity of Near-Peer Teaching in Training of Basic Surgical Skills – A Randomized Controlled Trial
Authors: Pintér Zsolt , Kardos Dániel , Varga Péter , Kopjár Eszter , Kovács Anna , Than Péter , Rendeki Szilárd , Czopf László , Füzesi Zsuzsanna , Schlégl Ádám Tibor 
Published: September 2020

Abstract
BackgroundNear-peer teaching (NPT) is a special way of teaching where the tutor is one or more academic years ahead of the person being tutored. The literature agrees on the benefits of the method, but there are only a few publications examining its effectiveness using objective methods. The aim of our study was to examine the effectiveness of NPT in the training of basic surgical skills.MethodsWe included 60 volunteer students who participated in a 24-hour basic surgical skills course. Based on the results of a pre-course test, we randomly divided the students into six equal groups. All groups completed the same curriculum, with three groups being assisted by a NPT tutor. After the course, they completed the same test as at the beginning. The exams were recorded on anonymized videos and were blindly evaluated. The students’ satisfaction was monitored using a self-administered online anonymous questionnaire. Statistical analysis was performed using the Mann-Whitney and Wilcoxon tests.ResultsOverall, student performance improved with completion of the course (from 119.86 to 153.55 points, p<0.01). In groups where a NPT tutor assisted, students achieved a significantly better score (37.20 vs. 30.18 points, p=0.036). The difference was prominent in surgical knotting tasks (14.73 vs. 9.30 points improvement, p<0.01). In cases of suturing (15.90 vs. 15.46 points) and laparoscopy (7.00 vs. 4.98 points), the presence of the NPT tutor did not significantly affect development. Based on student feedback, although students positively assessed the presence of NPT, it did not significantly improve students’ overall satisfaction.ConclusionsOverall, the use of NPT had a positive impact on student development. An outstanding difference was observed in connection with knotting techniques. The teaching of knot tying requires a high degree of personalized attention, which can be better realized with the assistance of a NPT tutor.
Factors Associated with Ocular Surface Epithelial Damage in Patients with Primary Sjögren's syndrome
Authors: Kim Ji Eun , Kim Na Rae , Chin Hee Seung , Seo Kyoung Yul , Kim Tae Im , Jung Ji Won 
Published: September 2020

Abstract
Background: The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren's syndrome (pSS).Methods: A total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5M were performed, and the Ocular Surface Disease Index was determined. Results: In a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 for and β = 0.040, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049).Conclusions: Ocular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function.
Meta-analysis of Pulmonary Artery Denervation for Treatment of Pulmonary Hypertension
Authors: Zuo Wanyun , Xiao Yunbin , Xie Yonghui , Liu Na , Liu Qiming 
Published: September 2020

Abstract
Objective: Pulmonary artery denervation (PADN) can reduce sympathetic nervous system (SNS) activity in patients with pulmonary hypertension (PH), reduce pulmonary artery pressure (PAP) in PH patients, and improve the quality of life in PH patients. We conducted a systematic meta-analysis of the effectiveness of PADN in the treatment of PH patients. Methods: All public clinical trials investigating the effects of PADN on PH. Outcomes were average pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), cardiac output (CO), right ventricular (RV) Tei index, 6-minute walk distance (6MWD), and New York Heart Association (NYHA) cardiac function grading. Results: A total of eight clinical studies including 213 PH patients with PADN were included. Meta-analysis showed that after PADN, mPAP (MD -12.51, 95% CI -17.74 to -7.27, P＜0.00001) (mmHg) and PVR (MD = -5.17, 95% CI -7.70 to -2.65, P <0.0001) (wood unit) decreased significantly, CO (MD 0.59, 95% CI 0.32 to 0.86, P＜0.0001) (L/min) and 6MWD (MD 107.75, 95% CI 65.64 to 149.86, P ＜0.00001) (meter) increased significantly, and RV Tei index (MD -0.05, 95% CI -0.28 to 0.17, P = 0.63) did not change significantly. And after PADN, the proportion of NYHA cardiac function grading (RR = 0.23, 95% CI 0.14 to 0.37, P <0.00001) III and IV decreased significantly.Conclusion: This meta-analysis supports PADN as a potential new treatment for PH. Further high-quality randomized controlled studies are needed.
Relationship Between Vitamin D Receptor Gene polymorphisms (BsmI, TaqI, ApaI, and FokI) and Calcium Intake on Bone Mass in Young Japanese Women
Authors: Sakamoto Yuri , Oono Fumi , Iida Kaoruko , Wang Pao-Li , Tachi Yoichi 
Published: September 2020

Abstract
Background: The increasing prevalence of low bone mass in young women in Japan has emerged as a serious health issue in recent years. Therefore, the aim of the present study was to reevaluate the relationship between genetic and dietary factors, as well as its influence on bone mass in young Japanese women, with particular emphasis on vitamin D receptor (VDR) gene polymorphisms and calcium intake. Methods: A total of 499 Japanese women aged 20–24 years were enrolled in the study. The bone mass of the calcaneus was assessed using the quantitative ultrasound method and expressed as the osteo sono-assessment index (OSI). VDR gene polymorphisms (BsmI, TaqI, ApaI, and FokI) were analyzed using DNA extracted from saliva. Calcium intake was assessed using the Food Frequency Questionnaire based on food groups (FFQg) and adjusted with respect to the energy intake. Participants were divided into two groups based on the median calcium intake (250 mg/1,000 kcal). Results: Consequently, bone mass was significantly different among the BsmI genotypes and Taq I genotypes after adjusting the body mass index (BMI) (p = 0.030 and 0.019, respectively). In addition, the BsmI AA and Apa I GT genotypes showed significant differences in bone mass between the calcium-intake groups, low OSI in the low-calcium intake group and high OSI in the high-calcium intake group, respectively, even after adjusting for covariates (p = 0.020 and 0.038, respectively). Conclusions: These findings would prove instrumental in developing a logical approach towards preventing bone loss in young Japanese women.