bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transferencia tecnológica para la producción limpia en la minería de materiales aluviales en La Guajira, Colombia
Authors: Polo Bornachera Kevin , López Juvinao Danny Daniel , Henríquez Jaramillo Alfonso 
Published: April 2020

Objetivo: Analizar la transferencia tecnológica para la producción limpia en la minería de materiales aluviales en La Guajira, Colombia. Metodología: La investigación fue de tipo descriptiva, con diseño no experimental, transeccional y de campo. La población estuvo conformada por tres empresas: Agregados Río Negro, Valores y Contratos S.A. “Valorcon S.A.” y La Macuira Inversiones y Construcciones S.A, que conforman el sector de la minería de materiales aluviales en La Guajira. Para la recolección de datos se utilizó como técnica la encuesta, empleándose como instrumento dirigido a los informantes, con preguntas cerradas y cinco alternativas de respuesta, constituido por 49 ítems. Se aplicó la validez de criterio con expertos, luego se realizó el cálculo de la confiabilidad a través del coeficiente Alfa de Cronbach, obteniéndose un valor de 0,90. Resultados: Se encontró que la mayor parte de la población realiza la transferencia directamente con el proveedor de la tecnología, es decir solo intervienen un receptor y quien provee, la población estudiada a veces asiste a ferias y congresos para obtener información sobre nuevas tecnologías, y entre las barreras se destaca que gran parte de la población no utiliza tecnologías adecuadas para la producción limpia. Conclusiones: La transferencia de tecnología en las empresas estudiadas estuvo enmarcada por las carencias de tecnologías que propicien una producción limpia, el factor competitivo de la tecnología y aumento de la calidad de los proyectos.
Expression of growth factors and tyrosine kinase receptors in the primary tumor and tumor thrombus cells in patients with renal cell carcinoma
Authors: Volkova M. I. , Olshanskaya A. S. , Tsimafeyeu I. V. , Vashakmadze N. L. , Khochenkova Yu. A. , Solomko E. Sh. , Ashuba S. A. , Khochenkov D. A. , Matveev V. B. 
Published: April 2020

Objective: to assess the expression and prognostic value of vascular endothelial growth factor A (VEGF-A), fibroblast growth factor 2 (FGF-2) and their receptors VEGFR-1, -2; FGFR-1, -2, as well as platelet-derived growth factor receptors (PDGFR-α, PDGFR-β) in paired samples of primary tumors and tumor thrombi in renal cell carcinoma (RCC).Materials and methods. Expression of VEGF-A, FGF-2, VEGFR-1, -2; FGFR-1, -2; PDGFR-α, -β was studied in paired surgical samples of primary tumors and tumor thrombi in 25 patients with clear cell RCC pT3a–T4N0–1M0–1 and tumor venous thrombosis by immunohistochemical assay using the appropriate Abcam/Santa Cruz Biotech antibodies from the immunohistochemical staining kit Invitrogen. Expression levels were evaluated by a semi-quantitative method (H-score). The analysis of the correlation between expression levels of VEGF-A, FGF-2, VEGFR-1, -2; FGFR-1, -2; PDGFR-α, -β and RCC characteristics, as well as evaluation of their influence on the outcome of RCC were performed.Results. VEGF-A, FGF-2, as well as VEGFR-1, -2; FGFR-1, -2; PDGFR-α, -β were expressed in the cytoplasm and on the membrane of the primary tumor and tumor thrombus cells in RCC patients. Tumor thrombus cells were characterized by lower expression of VEGFR-1, VEGFR-2, PDGFR-α (p <0.05 for all) and tendency to lower expression of VEGF-A (p = 0.060), FGF-2 (p = 0.046), FGFR-1 (p = 0.077) and FGFR-2 (p = 0.090) compared with primary tumor cells. RCC Furman grade correlated with the expression levels of VEGFR-1 (p = 0.035) and FGFR-1 (p = 0.022) in the primary tumor cells, tumor invasion into venous wall correlated with the expression levels of VEGFR-1 (p = 0.023) and FGFR-2 (p = 0.005) on the thrombus cells. VEGFR-2 overexpression in the primary tumor cells was associated with significant decrease of overall survival (OS) rate (p = 0.011). There was a tendency to OS deterioration in cases with overexpression of VEGFR-2 (p = 0.093) and VEGF-A (p = 0.095) in the tumor thrombus cells. One-year OS in patients with ³2 identified risk factors was 27.3 %, <2 risk factors – 87.5 % (p = 0.004).Conclusion. Tumor thrombus cells in RCC patients expressed VEGF-A, FGF-2, VEGFR-1, -2; FGFR-1, -2; PDGFR-α, -β less active than the cells of the primary tumor. Overexpression of growth factors and tyrosine kinases correlated with RCC Furman grade and tumor venous wall invasion. Overexpression of VEGFR-2 in both primary tumor and thrombus cells in combination with hypoexpression of VEGF-A in the thrombus negatively influenced on OS.
Oncological results of neoadjuvant chemohormonal therapy in patients with high and very high-risk prostate cancer
Authors: Berkut M. V. , Artemjeva A. S. , Reva S. A. , Tolmachev S. S. , Petrov S. B. , Nosov A. K. 
Published: April 2020

TolsotogoSt., Saint Petersburg 197022, RussiaBackground.Prostate cancer (PCa) of a high and very high risk is a potentially fatal disease that requires an active multimodal approach, including the use of neoadjuvant drug treatment. As option for this treatment is neoadjuvant chemohormonal therapy (NCHT) followed by radical prostatectomy (RPE). However, data on the oncological results of treatment of such patients are still limited and the role of neoadjuvant therapy in the treatment of high and very high-risk PCa remains not fully understood.Objective:toassesstheoncologicalresultsoftreatmentpatientswithlocalizedandlocallyadvancedPCaofhighandveryhighriskafterNCHT.Materials and methods.This was a prospective randomized study: patients with PCa of high and very high-risk groups (prostate specific antigen levels (PSA) >20 ng/ml and/or Gleason score³8and/or clinical stage >T2c) were treated with RPE only (group RPE; n = 35) or NCHT followed by RPE (NCHT/RPE group; n = 36). The neoadjuvant course included the intravenous administration of docetaxel once every 21 days (75 mg/m2 up to 6 cycles) and the antagonist of the gonadotropin releasing hormone degarelix according to the standard scheme (6 subcutaneous injections every 28 days). After a follow-up examination evaluating the result of the neoadjuvant regimen, patients underwent RPE with extanded lymphadenectomy.Results.A mean follow-up was 37.08 ± 20.46 months. A statistically significant reduction of prostate specific antigen >50 % post-chemohormonal therapy was observed in all 36 cases. Lower postoperative stage was noticed in 38.5 % in NCHT/RPE group compared with 2.7 % in RPE group. Similarly, positive surgical margin rate was higher in group without neoadjuvant therapy – 40 and 25 % (RPE group). Cancerspecific survival was 97.2 % in NCHT/RPE group and 87.56 % in the RP group (p = 0.037), cancer specific survival rate – 91.4 % and97.2 % respectively (log-rank test p = 0.22). At the same time, no statistically significant differences were obtained in 3-year recurrence free survival between groups: 38.8 % in NCHT/RPE group versus 43.6 % in the RPE group (log-rank test p = 0.36).Conclusion.Conducting NCHT before RPE is a safe and effective strategy in patients with PCa of high and very high risk groups and could improve oncological results.
Early complications of radical cystectomy with various types of urine diversion: prognostic factors analysis
Authors: Musayev T. N. 
Published: April 2020

Objective: to analyze factors predicting complications in a series of radical cystectomies (RCs) performed for bladder cancer over a 10-year period at the National Center of Oncology (Baku).Materials and methods. From July 2008 to December 2017 we retrospectively selected 257 consecutive cases of RC with pelvic lymphadenectomy and various options of urine diversion for bladder malignant neoplasms. Information on preoperative prognostic factors, including demographic parameters, as well as general patient health parameters, tumor characteristics and factors concerning the operation was obtained from medical records. We analyzed perioperative factors using monovariant logistic regression, where the endpoints were development of any complication (I–V degrees according to Clavien–Dindo classification), as well as severe complication (III–V grades) within 30-days after RC were considered the endpoints. After the missing data on preoperative bacteriological urinalysis were multiply imputed, a multivariate logistic regression has been performed with odds ratio (OR) calculation.Results. During the 30-day period, complications were registered in 111 (43.2 %) patients, severe complications – in 48 (18.7 %). Multivariate analysis revealed the following independent predictors of any postoperative complications after RC: local cT4 tumor extension (OR 4.52; p = 0.002), age (OR 1.87; p = 0.017), positive bacteriological urine analysis (OR 2.16; p = 0.032) and number of performed RCs (OR 0.89; p = 0.038). Severe postoperative complications were associated with positive urine culture (OR 4.05; p = 0.002) and age (OR 2.44; p = 0.013).Conclusion. Our study revealed the following independent factors, which were significantly associated with the risk of any complication or severe complication after RC: local cT4 tumor extension, age, positive urine bacteriological analysis before the intervention and a small number of surgeries or positive urine culture and age, respectively.
Anogenital Warts Prevalence and Associated Risk Factors among MSM Population in Surakarta, Indonesia
Authors: Soenardi Ancella , Fiqri Ahmad , Trisnarizki Leonardo , Kariosentono Harijono , Probandari Ari Natalia , Mawardi Prasetyadi , Redhono Dhani , Ellistasari Endra Yustin 
Published: April 2020

To know anogenital warts prevalence and its correlation with HIV infection in men who have sex with men (MSM) population in Surakarta, Indonesia. To identify risk factors associated with anogenital warts among MSM population in Surakarta, Indonesia.
This cross-sectional study collects data from MSM population in Surakarta, Indonesia. Patients are MSM who joined monthly mobile clinic held by the health government of Surakarta and those who attend the Voluntary Consultation and Testing Clinic of Dr. Moewardi General Hospital. Risk factors were asked using questionnaire. Physical examination was used to diagnose anogenital warts, and took blood samples for HIV screening.
From 190 subjects, 25 (13.1%) had anogenital warts, and 17 (8.9%) are HIV positive. Anogenital warts increase the odds of having HIV infection by 5.18 times. Risk factors that contribute to anogenital warts include age 25-34 years old (OR= 3,729) and a history of drug abuse (OR= 7.184).
This research only uses simple physical examination to diagnose anogenital warts, and the small study subjects may not be representative of general MSM population in Indonesia.
Age 25-34 years old and history of drug abuse are substantial risk factors for anogenital warts. Having anogenital warts infection increases the odds of acquiring HIV. This study highlights the importance of STD screening especially in high-risk population such as MSM, which currently is still neglected by the Health Department of Indonesia.
Long-term results of tonsillectomy in professional opera singers: a pilot study
Authors: Clarós Pedro , Sobolewska Aleksandra , Pujol María Del Carmen , Clarós-Pujol Astrid , Clarós Andrés 
Published: April 2020

<p class="abstract"><strong>Background:</strong> The primary goal of this study was to evaluate the long-term influence of tonsillectomy on the quality of life and voice performance of opera singers. Survey study which was reviewing the long-term effects of tonsillectomy. </p><p class="abstract"><strong>Methods:</strong> Retrospective review of patients’ records and surveys in which patients have answered the questions about the influence of tonsillectomy on their voice. A total group of 30 singers was included in the study. They answered the questions about the indications for surgery, symptoms, and changes in their voice after surgery. The study group consisted of 19 women and 11 men. Mean age was 18.53 years old at the moment of surgery. The group included eleven sopranos, six mezzos, two contraltos, four tenors, five baritones, and one bass singer. </p><p class="abstract"><strong>Results:</strong> A most common indication for tonsillectomy in opera singers was recurrent tonsillitis and was present in over 83% of cases. After surgery, the voice performance was better in 60% of cases, breathing improved in 50% of cases, voice emission was higher in 53% of cases. Over 80% of singers would recommend that surgery to another opera singer.</p><p class="abstract"><strong>Conclusions:</strong> Singers evaluated long-term influence of tonsillectomy as positive. Over 80% admitted improved effect on emission and the function of voice.</p>
Expression of proliferation markers in laryngeal squamous cell carcinoma: an association with clinico-pathological factors and treatment outcomes
Authors: Iype Elizabeth Mathew , Balakrishna Rajan , Subhadradevi Lakshmi , Thulaseedharan Jissa Vinoda , Veerabadhran Bharath , Kattoran Jayasree 
Published: April 2020

<p class="abstract"><strong>Background:</strong> The study was done with the objective to study the expression of epidermal growth factor receptor (EGFR), cyclin D1 and Ki-67 in laryngeal squamous cell carcinoma and to assess the correlation of all three proliferation markers with various clinic-pathological parameters, the treatment outcomes as well as survival.</p><p class="abstract"><strong>Methods:</strong> We prospectively evaluated the surgical specimens of 72 laryngeal squamous cell carcinoma (LSCC) patients, treated with primary surgery and post-operative adjuvant therapy. Tumor tissue samples were analysed for the expression of EGFR, cyclin D1 and Ki-67 markers and analysis were done by immune-histochemistry and western blot test. </p><p class="abstract"><strong>Results:</strong> EGFR showed significant expression in 67.6% and was insignificant in 31.9% patients in our analysis of 72 tumor samples. Cyclin D1 showed intense expression in 43%, and was insignificant in 57% patients. Ki-67 was intensely expressed in 43% patients. There was no correlation between expression of these markers with age, T-stage and N-stage. However, all the three markers showed significantly intense expression in tumours with extra capsular disease as well as perineural invasion (PNI) both of which are features of invasiveness of the tumor.</p><p class="abstract"><strong>Conclusions:</strong> Estimation of biomarkers such as EGFR, cyclin Dl, and Ki-67 could be beneficial in predicting tumor aggressiveness, prognosis and survival in LSCC patients. Thus, all the three proliferation markers can be categorized as markers of invasiveness. Combination of proliferation markers-EGFR, cyclin D1 and Ki-67 is useful pre-operatively in planning surgical strategies so as to decide a more radical approach for the resection of the primary as well as neck dissection.</p>
Occurrence of deviated nasal septum in terms of angles and its relation with sinus disease in patients of chronic rhinosinusitis: a computed tomography scan study
Authors: Sonone Jayant K. , Garg Deepika , Solanke Poonam S. 
Published: April 2020

<p class="abstract"><strong>Background:</strong> The intention of this study was to evaluate angles of nasal septal deviation by measuring angle of nasal septal deviation on computerized tomography of the para nasal sinuses (CT PNS) and to study the effect of increasing septal angle on chronic sinusitis. No other study in the literature has measured exact angle of septal deviation in terms of degrees.</p><p class="abstract"><strong>Methods:</strong> A prospective cross-sectional observational study was carried out from September 2015 to August 2017 and 57 patients with diagnosis of having chronic sinusitis, were evaluated with CT PNS (coronal and axial views). </p><p class="abstract"><strong>Results:</strong> Most patients of chronic rhinosinusitis had septal deviation in grade III, followed by grade II, then grade I.</p><p class="abstract"><strong>Conclusions:</strong> This study concludes that higher the angle of septal deviation, higher the incidence of CRS and vice versa.</p><p> </p>
Introduction of a new key step in lateral approach thyroidectomy: a randomised prospective study on thirty patients
Authors: Phookan Jyotirmoy , Gupta Shilpi 
Published: April 2020

<p class="abstract"><strong>Background:</strong> The school of Bilroth in Vienna started modern thyroid surgeries in 1860s.<sup>1</sup> Thyroidectomy was associated with high mortality, recurrent laryngeal nerve injuries and tetany. One and a half century down the timeline, complications still occur. Although, in experienced hands, the thyroid surgeries performed today are associated with minimal mortality and morbidity. Lateral approach thyroidectomy is a commonly practiced approach with fewer complications. We carried out a study to assess the efficacy, safety and advantages of lateral approach thyroidectomy with a new key step.</p><p class="abstract"><strong>Methods:</strong> A prospective study was performed on thirty patients undergoing conventional open thyroidectomy from January to July 2019 at a tertiary care hospital in north east India. All patients underwent open thyroidectomy via lateral approach in which identifying superior belly of omohyoid was considered a key step of surgery. Basic demographic data, preoperative diagnosis, operative time, blood loss, need for transection of strap muscles and complications were recorded. </p><p class="abstract"><strong>Results:</strong> There were no intra-operative complications, without the need to cut strap muscles or sacrifice superior belly of omohyoid in any case. Voice change was seen in one case, improved after steroid administration. One case developed tetany after total thyroidectomy managed with calcium supplements.</p><p class="abstract"><strong>Conclusions:</strong> Results suggested that lateral approach of thyroidectomy is a quick and safe technique where identification of superior belly of omohyoid considered as our key step, enabled easy delivery of superior pole of thyroid and facilitates easy identification and preservation of vital structures; thus, causing least morbid sequelae.</p>
Evaluation of pectoralis major myocutaneous flap at tertiary care hospital: retrospective study of 60 cases
Authors: Parmar Bhagirathsinh D. , Jha Sushil , Sinha Vikas , Meshram Sonal , Dave Gavendra P. , Rajpurohit Bhagwansingh 
Published: April 2020

<p class="abstract"><strong>Background:</strong> Reconstruction following advanced oral cancer is a formidable task in developing country, with poor infrastructure and heavy chunk of advanced stage (T3-T4) oral malignancy. Options available for reconstructions are regional pedicle flaps and microvascular free flaps. Pedicle flaps particularly the pectoralis major myocutaneous (PMMC) flap have an easy learning curve for most of surgeons. Pectoralis major myocutaneous flap is regarded as the workhorse for reconstruction in many head and neck surgeries.</p><p class="abstract"><strong>Methods:</strong> A study was undertaken on patients of soft tissue defects of head and neck region after resection of tumor of oral cavity (squamous cell carcinoma). Total 60 patients, who were managed in ENT department, Sir T hospital, Bhavnagar from 2016-19 were included in this study. </p><p class="abstract"><strong>Results:</strong> Gingivo-buccal complex was the most common site observed for oral malignancy and majority of patients were in TNM stage-I, II, III in this study. Apart from total flap necrosis observed in 1 patient, in rest all the patients PMMC flap very well survived with some major/minor, flap related and unrelated complications.</p><p class="abstract"><strong>Conclusions:</strong> The PMMC flap is effective in reconstruction of defect after excision of oral cavity cancers in developing country with heavy chunk of oral cavity cancer patients. In spite of several minor flap related and flap unrelated complications, PMMC flap survival rate is high and total flap necrosis rate is very low.</p>
Laryngeal diphtheria: still a problem
Authors: Ali Mohamed Riyas , Devi Taorem Medhabati , Meher Ravi , Passey Jai Chand , Singh Ishwar , Shereen Fathima 
Published: April 2020

<p class="abstract"><strong>Background:</strong> Globally diphtheria has been showing a declining trend due to effective childhood vaccination programmes. However, inadequate healthcare delivery systems and other social factors have led to diphtheria re-emerging and remaining endemic in many regions of the world. Securing airway by emergency tracheostomy plays a pivotal role in the management of laryngeal diphtheria in addition to antitoxin.</p><p class="abstract"><strong>Methods:</strong> This was a retrospective study conducted in Department of ENT, Maulana Azad Medical College from January 2015 to December 2018. The study included cases of diphtheria with stridor or impending airway obstruction. The information collected included age, gender, socioeconomic status and immunization status. The month of presentation was noted to establish the seasonal trend of the infection. </p><p class="abstract"><strong>Results:</strong> Maximum number of cases was in the age group of 3 to 9 years (62.3% of total cases). Male children predominated over female children with overall sex ratio of 3:1. Most of the cases presenting to us were partially immunized (51.8%) or unimmunized (44.6%). The maximum number of cases was reported in the month of August to November (96 out of 122 cases). Emergency tracheostomy was done in 86.9% (106 out of 122 cases).</p><p class="abstract"><strong>Conclusions:</strong> Diphtheria still continues to be a major public health issue in India. Early recognition and treatment are necessary to prevent morbidities and mortalities. Tracheostomy is a speedy and efficient lifesaving procedure in the management of laryngeal diphtheria.</p><p class="abstract"> </p>
Comparative study between over underlay with classical underlay techniques of tympanoplasty
Authors: Basavaraj Prashanth Kudure , Anandappa Manjunatha H. , Prabhakaran Veena , Sharma Nishtha , Karkala Shreyas 
Published: April 2020

<p class="abstract"><strong>Background:</strong> The objective of the study was to compare the over underlay tympanoplasty technique with classical underlay tympanoplasty in terms of hearing impairment, graft acceptance and complications.</p><p class="abstract"><strong>Methods:</strong> 60 patients of chronic otitis media, mucosal, inactive, aged between 16-60 years who presented to ENT OPD with small, medium, large and subtotal perforations having mild to moderate conductive hearing loss were included in the study. After taking informed consent, patients were randomly divided into 2 groups containing 30 patients each. In group A, graft was placed medial to the handle of malleus and medial to the annulus (underlay technique), while in group B, graft was placed lateral to the handle of malleus and medial to the annulus (over underlay technique). Both groups were reviewed after 6 months. Pre-operative and post-operative air bone gap were compared. Surgery was considered successful based on post-operative graft uptake, hearing improvement and maintenance of middle ear space. </p><p class="abstract"><strong>Results:</strong> In group A, re-perforation was seen in 8 cases (26.7%) whereas only 3 cases (10%) in group B had re-perforation. Medialization was noted among 4 patients in group A (13.3%), and was absent in group B. Lateralization was absent in both the groups. Post-operative hearing threshold in group A was 6.2±4.56 dB and in group B was 11.45±7.38 dB.</p><p class="abstract"><strong>Conclusions:</strong> Over underlay tympanoplasty is a safer technique as compared to classical underlay, showing lower rates of re-perforation or medialization and a significant improvement in hearing. Hence over-underlay is an effective method, having higher success rates.</p>