bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced caregiving quality measured during the strange situation procedure increases child’s autonomic nervous system stress response
Authors: Köhler-Dauner Franziska , Roder Eva , Krause Sabrina , Buchheim Anna , Gündel Harald , Fegert Jörg M. , Ziegenhain Ute , Waller Christiane 
Published: October 2019

Abstract

Background
Dysfunctional maternal behavior has been shown to lead to disturbances in infant’s regulatory capacities and alterations in vagal reactivity. We aim to investigate the autonomic nervous system (ANS) response of the child during the strange situation procedure (SSP) in relation to the quality of maternal behavior.

Methods
Twelve month after birth, 163 mother–child-dyads were investigated during the SSP. Heart rate (HR) and both, the parasympathetic branch (PNS) via the respiratory sinus arrhythmia (RSA) and the sympathetic branch (SNS) via the left ventricular ejection time (LVET) of the ANS were continuously determined during the SSP using electrocardiogram (ECG) and impedance cardiogram (ICG) measures. Maternal behavior was assessed by using the AMBIANCE measure.

Results
The ANS response in infants of mothers with disruptive behavior compared to infants of non-disruptive mothers was significantly altered during the SSP: HR increased especially when infants of disruptive mothers were alone with the stranger (F (1, 161) = 4.15, p = .04) with a significant vagal withdrawal when being in contact with the stranger despite of presence of the mother (F (1, 161) = 5.11, p = .03) and a significant increase in vagal tone during final reunion (F (1, 161) = 3.76, p = .05). HR increase was mainly based on a decrease in LVET (F (1, 161) = 4.08, p = .05) with a maximum infant’s HR when the stranger came into the room instead of the mother.

Conclusion
Both, SNS and PNS branches of the child are significantly altered in terms of an ANS imbalance, especially during contract to a stranger, in relation to dysfunctional maternal behavior. Our findings suggest the importance of supporting high quality caregiving that enables the infant to adapt adequately to stressful interpersonal situations which is likely to promote later health.
Stable transmission of complex chromosomal rearrangements involving chromosome 1q derived from constitutional chromoanagenesis
Authors: Gudipati Mary A. , Waters Elizabeth , Greene Carol , Goel Nidhi , Hoppman Nicole L. , Pitel Beth A. , Webley Matthew R. , Zou Ying 
Published: October 2019

Abstract

Background
Chromoanagenesis events encompassing chromoanasynthesis, chromoplexy, and chromothripsis are described in cancers and can result in highly complex chromosomal rearrangements derived from ‘all-at-once’ catastrophic cellular events. The complexity of these rearrangements and the original descriptions in cancer cells initially led to the assumption that it was an acquired anomaly. While rare, these phenomena involving chromosome 1 have been reported a few individuals in a constitutional setting.

Case presentation
Here, we describe a newborn baby who was initially referred for cytogenetic testing for multiple congenital anomalies including cystic encephalomalacia, patent ductus arteriosus, inguinal hernia, and bilateral undescended testicles. Chromosome analysis was performed and revealed a derivative chromosome 1 with an 1q24-q31 segment inserted into 1q42.13 resulting in gain of 1q24-q31. Whole genome SNP microarray analysis showed a complex pattern of copy number variants with four gains and one loss involving 1q24-q31. Mate pair next-generation sequencing analysis revealed 18 chromosome breakpoints, six gains along an 1q24-q31 segment, one deletion of 1q31.3 segment and one deletion of 1q42.13 segment, which is strongly evocative of a chromoanasynthesis event for developing this complex rearrangement. Parental chromosome analyses were performed and showed the same derivative chromosome 1 in the mother.

Conclusions
To our knowledge, our case is the first case with familial constitutional chromoanagenesis involving chromosome 1q24-q42. This report emphasizes the value of performing microarray and mate pair next-generation sequencing analysis for individuals with germline abnormal or complex chromosome rearrangements.
Contaminating reactivity of a monoclonal CCAAT/Enhancer Binding Protein β antibody in differentiating myoblasts
Authors: AlSudais Hamood , Wiper-Bergeron Nadine 
Published: October 2019

AbstractObjectiveCCAAT/Enhancer Binding proteins (C/EBPs) are transcription factors involved in the regulation of a variety of cellular processes. We used the Abcam Recombinant Anti-C/EBP beta antibody (E299) to detect C/EBPβ expression during myogenesis. Though the antibody is monoclonal, and the immunogen used is highly specific to C/EBPβ, we identified an intense band at 23 kDa on western blot that did not correspond to any of the known isoforms of C/EBPβ, or family members predicted to cross-react. Absent in myoblast cells overexpressing C/EBPβ, the band was present when C/EBPβ was knocked down, confirming specificity for a protein other than C/EBPβ. The objective of this work was to identify the contaminating reactivity.ResultsWe performed immunoprecipitation followed by mass spectrometry to identified myosin light chain 4 (MYL4) as the unknown band, suggesting that the Abcam monoclonal antibody directed against C/EBPβ is not pure, but contains a contaminating antibody against MYL4. Caution should be used when working in cells lines that express MYL4 to not confound the detection of MYL4 with that of C/EBPβ isoforms.
Overweight and obesity among children under five in Ethiopia: further analysis of 2016 national demographic health survey: a case control study
Authors: Weldearegay Haftom Gebrehiwot , Gebrehiwot Tesfay Gebregzabher , Abrha Mulugeta Woldu , Mulugeta Afework 
Published: October 2019

Abstract

Objective
The objective of this study was to assess the determinants of overweight and obesity among children under 5 years in Ethiopia.

Results
Data from a total of 672 (224 cases and 448 controls) under 5 years of age children were included in the study. Urban residence (AOR = 2.63, 95% CI 1.29, 5.34), boys (AOR = 1.56, 95% CI 1.10, 2.22) and age of the child less than 6 months (AOR = 3.40, 95% CI 2.05, 5.64) were the determinants for being childhood overweight and obesity.
Stochastic modeling and analysis of vapor cloud explosions domino effects in chemical plants
Authors: Sierra Diego , Montecchi Leonardo , Mura Ivan 
Published: October 2019

Abstract
Because of the substances they process and the conditions of operation, chemical plants are systems prone to the occurrence of undesirable and potentially dangerous events. Major accidents may occur when a triggering event produces a cascading accident that propagates to other units, a scenario known as domino effect. Assessing the probability of experiencing a domino effect and estimating the magnitude of its consequences is a complex task, as it depends on the nature of the substances being processed, the operating conditions, the failure proneness of equipment units, the execution of preventive maintenance activities, and of course the plant layout. In this work, we propose a stochastic modeling methodology to perform a probabilistic analysis of the likelihood of domino effects caused by propagating vapor cloud explosions. Our methodology combines mathematical models of the physical characteristics of the explosion, with stochastic state-based models representing the actual propagation among equipment units and the effect of maintenance activities. Altogether, the models allow predicting the likelihood of major events occurrence and the associated costs. A case study is analyzed, where various layouts of atmospheric gasoline tanks are assessed in terms of the predicted consequences of domino effects occurrence. The results of the analyses show that our approach can provide precious insights to support decision-making for safety and cost management.
Impact of artificial intelligence on radiology: a EuroAIM survey among members of the European Society of Radiology
Authors:   European Society of Radiology (ESR)
Published: October 2019

Abstract
We report the results of a survey conducted among ESR members in November and December 2018, asking for expectations about artificial intelligence (AI) in 5–10 years. Of 24,000 ESR members contacted, 675 (2.8%) completed the survey, 454 males (67%), 555 (82%) working at academic/public hospitals. AI impact was mostly expected (≥ 30% of responders) on breast, oncologic, thoracic, and neuro imaging, mainly involving mammography, computed tomography, and magnetic resonance. Responders foresee AI impact on: job opportunities (375/675, 56%), 218/375 (58%) expecting increase, 157/375 (42%) reduction; reporting workload (504/675, 75%), 256/504 (51%) expecting reduction, 248/504 (49%) increase; radiologist’s profile, becoming more clinical (364/675, 54%) and more subspecialised (283/675, 42%). For 374/675 responders (55%) AI-only reports would be not accepted by patients, for 79/675 (12%) accepted, for 222/675 (33%) it is too early to answer. For 275/675 responders (41%) AI will make the radiologist-patient relation more interactive, for 140/675 (21%) more impersonal, for 259/675 (38%) unchanged. If AI allows time saving, radiologists should interact more with clinicians (437/675, 65%) and/or patients (322/675, 48%). For all responders, involvement in AI-projects is welcome, with different roles: supervision (434/675, 64%), task definition (359/675, 53%), image labelling (197/675, 29%). Of 675 responders, 321 (48%) do not currently use AI, 138 (20%) use AI, 205 (30%) are planning to do it. According to 277/675 responders (41%), radiologists will take responsibility for AI outcome, while 277/675 (41%) suggest shared responsibility with other professionals. To summarise, responders showed a general favourable attitude towards AI.
Epigenetic heterogeneity in cancer
Authors: Guo Mingzhou , Peng Yaojun , Gao Aiai , Du Chen , Herman James G. 
Published: October 2019

Abstract
Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor genotype variations among tumors within different patients are known as interpatient heterogeneity, and variability among multiple tumors of the same type arising in the same patient is referred to as intra-patient heterogeneity. Subpopulations of cancer cells with distinct phenotypic and molecular features within a tumor are called intratumor heterogeneity (ITH). Since Nowell proposed the clonal evolution of tumor cell populations in 1976, tumor heterogeneity, especially ITH, was actively studied. Research has focused on the genetic basis of cancer, particularly mutational activation of oncogenes or inactivation of tumor-suppressor genes (TSGs). The phenomenon of ITH is commonly explained by Darwinian-like clonal evolution of a single tumor. Despite the monoclonal origin of most cancers, new clones arise during tumor progression due to the continuous acquisition of mutations. It is clear that disruption of the "epigenetic machinery" plays an important role in cancer development. Aberrant epigenetic changes occur more frequently than gene mutations in human cancers. The epigenome is at the intersection of the environment and genome. Epigenetic dysregulation occurs in the earliest stage of cancer. The current trend of epigenetic therapy is to use epigenetic drugs to reverse and/or delay future resistance to cancer therapies. A majority of cancer therapies fail to achieve durable responses, which is often attributed to ITH. Epigenetic therapy may reverse drug resistance in heterogeneous cancer. Complete understanding of genetic and epigenetic heterogeneity may assist in designing combinations of targeted therapies based on molecular information extracted from individual tumors.
Fabrication of transparent composites for non-invasive Surface Enhanced Raman Scattering (SERS) analysis of modern art works
Authors: Alyami Abeer , Mirabile Antonio , Iacopino Daniela 
Published: October 2019

Abstract
Surface Enhanced Raman Scattering (SERS) has become an invaluable tool for the identification of colorants in artworks, due to its enhanced sensitivity and ability to quench fluorescence interference compared to Raman spectroscopy. However, the application of SERS to artwork analysis is still limited by its inherent invasiveness and the need for extraction procedures. In this work non-invasive transparent SERS probes were fabricated by self-assembly of Ag nanoparticles into glass and PDMS surfaces and used for identification of dye content in artistic drawings. SERS measurements were performed directly on the selected analytical surfaces by laser back illumination through the SERS probe. The non-invasiveness of fabricated probes was tested by optical microscopy. It was found that Ag nanoparticle/glass probes left no Ag nanoparticle residue after four consecutive depositions on sacrificial surfaces, whereas Ag nanoparticle/PDMS composites could be deposited and subsequently peeled off the analytical surfaces leaving no contamination traces. The high conformability, flexibility and transparency of Ag nanoparticle/PDMS composites enabled good adhesion to the surface of analyzed artistic drawings and therefore the generation of in situ SERS spectra from artistic drawings. The use of this method allowed identification of main dye components in real artworks comprising a red BIC ballpoint drawing and a Japanese woodblock print.
Context-aware rule learning from smartphone data: survey, challenges and future directions
Authors: Sarker Iqbal H. 
Published: October 2019

AbstractSmartphones are considered as one of the most essential and highly personal devices of individuals in our current world. Due to the popularity of context-aware technology and recent developments in smartphones, these devices can collect and process raw contextual data about users’ surrounding environment and their corresponding behavioral activities with their phones. Thus,smartphone data analyticsand building data-drivencontext-aware systemshave gained wide attention from both academia and industry in recent days. In order to build intelligent context-aware applications on smartphones, effectively learning a set ofcontext-aware rulesfrom smartphone data is the key. This requires advanced data analytical techniques with high precision andintelligent decision makingstrategies based on contexts. In comparison to traditional approaches,machine learningbased techniques provide more effective and efficient results for smartphone data analytics and corresponding context-aware rule learning. Thus, this article first makes asurveyon previous work in the area of contextual smartphone data analytics and then presents a discussion ofchallengesandfuture directionsfor effectively learning context-aware rules from smartphone data, in order to build rule-based automated and intelligent systems.
A novel low voltage ride through strategy for cascaded power electronic transformer
Authors: Han Jiexiang , Kong Xiangping , Li Peng , Zhang Zhe , Yin Xianggen 
Published: October 2019

Abstract
In view of the operating characteristics for voltage sags of AC side of the power electronic transformer(PET), a low-voltage ride through(LVRT) strategy adapted to bidirectional power exchange of PET is proposed for the purposes of maintaining the system stability, assisting the system voltage recovery and protecting PET safety. During the asymmetric voltage sag, the negative sequence current of PET is eliminated to ensure the symmetry of the injected current. According to the degree of positive sequence voltage sag, the reactive current injection is provided to assist in voltage recovery. According to the PET active power condition before the voltage sag, the level and direction of which are maintained as far as possible without exceeding the limit, for which the disturbance to the AC and DC grids is reduced. Finally, the effectiveness of the proposed LVRT strategy is verified by simulation model.
"Za Krakowską Bramę rzadko się człowiek wypuszczał…"
Authors: Kubiszyn Marta 
Published: October 2019

"One Would Rarely Venture behind the Krakowska Gate…": Imaginary Boundaries of the Jewish District in Lublin in Memories of Pre‑war Inhabitants
Up until the World War II, Jews played an important role in the history of Lublin. At least since the 16th century, Jews had lived in the segregated district of Podzamcze, called the “Jewish Town”. Although they started to inhabit the Old Town in 1862 and eventually lived in all parts of Lublin by the interwar period, the former boundaries between the “Jewish” and “Christian” parts of the city remained strongly imprinted in social memory, affecting everyday existence. This article analyses the imaginary boundaries that delineated the “Jewish” district of Lublin in the pre‑World War II period. Drawing on oral testimonies of Christian residents of the city recorded in years 1998‑2005 and archival materials such as articles from local papers, documents of communal institutions, and photos from the 1920s and 1930s, the opposing categories of “ours” and “theirs” have been used to describe social relations in urban space. The author of the article argues that the persistence of segregation in shared memory is expressed not only in visual forms, but it also has sound, smell and taste dimensions.
Preliminary report of clinical experience with metal-on-highly-crosslinked-polyethylene hip resurfacing
Authors: Treacy Ronan B. C. , Holland James P. , Daniel Joseph , Ziaee Hena , McMinn Derek J. W. 
Published: October 2019

Objectives Modern metal-on-metal (MoM) hip resurfacing arthroplasty (HRA), while achieving good results with well-orientated, well-designed components in ideal patients, is contraindicated in women, men with head size under 50 mm, or metal hypersensitivity. These patients currently have no access to the benefits of HRA. Highly crosslinked polyethylene (XLPE) has demonstrated clinical success in total hip arthroplasty (THA) and, when used in HRA, potentially reduces metal ion-related sequelae. We report the early performance of HRA using a direct-to-bone cementless mono-bloc XLPE component coupled with a cobalt-chrome femoral head, in the patient group for whom HRA is currently contraindicated. Methods This is a cross-sectional, observational assessment of 88 consecutive metal-on-XLPE HRAs performed in 84 patients between 2015 and 2018 in three centres (three surgeons, including the designer surgeon). Mean follow-up is 1.6 years (0.7 to 3.9). Mean age at operation was 56 years (sd 11; 21 to 82), and 73% of implantations were in female patients. All patients were individually counselled, and a detailed informed consent was obtained prior to operation. Primary resurfacing was carried out in 85 hips, and three cases involved revision of previous MoM HRA. Clinical, radiological, and Oxford Hip Score (OHS) assessments were studied, along with implant survival. Results There was no loss to follow-up and no actual or impending revision or reoperation. Median OHS increased from 24 (interquartile range (IQR) 20 to 28) preoperatively to 48 (IQR 46 to 48) at the latest follow-up (48 being the best possible score). Radiographs showed one patient had a head-neck junction lucency. No other radiolucency, osteolysis, component migration, or femoral neck thinning was noted. Conclusion The results in this small consecutive cohort suggest that metal-on-monobloc-XLPE HRA is successful in the short term and merits further investigation as a conservative alternative to the current accepted standard of stemmed THA. However, we would stress that survival data with longer-term follow-up are needed prior to widespread adoption. Cite this article: R. B. C. Treacy, J. P. Holland, J. Daniel, H. Ziaee, D. J. W. McMinn. Preliminary report of clinical experience with metal-on-highly-crosslinked-polyethylene hip resurfacing. Bone Joint Res 2019;8:443–450. DOI: 10.1302/2046-3758.810.BJR-2019-0060.R1
Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion
Authors: Coelho-Lima Jose , Mohammed Ashfaq , Cormack Suzanne , Jones Samuel , Ali Adnan , Panahi Pedram , Barter Matt , Bagnall Alan , Ali Simi , Young David , Spyridopoulos Ioakim 
Published: October 2019

Abstract

BACKGROUND
Failed myocardial reperfusion occurs in approximately 50% of patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI). It manifests as microvascular obstruction (MVO) on cardiac magnetic resonance (CMR) imaging. Although prognostically important, MVO is not routinely screened for. Our aim was to investigate the kinetics of circulating short noncoding ribonucleic acids [microRNAs (miRNAs)] following PPCI and their association with MVO in STEMI patients.

METHODS
Screening of 2083 miRNAs in plasma from STEMI patients with (n = 6) and without (n = 6) MVO was performed by next-generation sequencing. Two candidate miRNAs were selected and quantified at 13 time points within 3 h postreperfusion in 20 STEMI patients by reverse transcription and quantitative PCR. Subsequently, these 2 miRNAs were measured in a “validation” STEMI cohort (n = 50) that had CMR imaging performed at baseline and 3 months post-PPCI to evaluate their association with MVO.

RESULTS
miR-1 and miR-133b were rapidly released following PPCI in a monophasic or biphasic pattern. Both miRNAs were enriched in circulating microparticles. A second miR-1 peak (90–180 min postreperfusion) seemed to be associated with a higher index of microvascular resistance. In addition, miR-1 and miR-133b levels at 90 min post-PPCI were approximately 3-fold (P = 0.001) and 4.4-fold (P = 0.008) higher in patients with MVO, respectively. Finally, miR-1 was significantly increased in a subgroup of patients with worse left ventricular (LV) functional recovery 3 months post-PPCI.

CONCLUSIONS
miR-1 and miR-133b levels increase within 3 h of PPCI. They are positively associated with MVO and worse LV functional recovery post-PPCI.
A Novel Online Calculator Based on Serum Biomarkers to Detect Hepatocellular Carcinoma among Patients with Hepatitis B
Authors: Yang Tian , Xing Hao , Wang Guoqiang , Wang Nianyue , Liu Miaoxia , Yan Cunling , Li Huijun , Wei Lianhua , Li Shunjun , Fan Zhuping , Shi Ming , Chen Wei , Cai Shangli , Pawlik Timothy M , Soh Andrew , Beshiri Agim , Lau Wan Yee , Wu Mengchao , Zheng Yijie , Shen Feng 
Published: October 2019

Abstract

BACKGROUND
Early detection of hepatocellular carcinoma (HCC) among hepatitis B virus (HBV)-infected patients remains a challenge, especially in China. We sought to create an online calculator of serum biomarkers to detect HCC among patients with chronic hepatitis B (CHB).

METHODS
Participants with HBV-HCC, CHB, HBV-related liver cirrhosis (HBV-LC), benign hepatic tumors, and healthy controls (HCs) were recruited at 11 Chinese hospitals. Potential serum HCC biomarkers, protein induced by vitamin K absence or antagonist-II (PIVKA-II), α-fetoprotein (AFP), lens culinaris agglutinin A-reactive fraction of AFP (AFP-L3) and α-L-fucosidase (AFU) were evaluated in the pilot cohort. The calculator was built in the training cohort via logistic regression model and validated in the validation cohort.

RESULTS
In the pilot study, PIVKA-II and AFP showed better diagnostic sensitivity and specificity compared with AFP-L3 and AFU and were chosen for further study. A combination of PIVKA-II and AFP demonstrated better diagnostic accuracy in differentiating patients with HBV-HCC from patients with CHB or HBV-LC than AFP or PIVKA-II alone [area under the curve (AUC), 0.922 (95% CI, 0.908–0.935), sensitivity 88.3% and specificity 85.1% for the training cohort; 0.902 (95% CI, 0.875–0.929), 87.8%, and 81.0%, respectively, for the validation cohort]. The nomogram including AFP, PIVKA-II, age, and sex performed well in predicting HBV-HCC with good calibration and discrimination [AUC, 0.941 (95% CI, 0.929–0.952)] and was validated in the validation cohort [AUC, 0.931 (95% CI, 0.909–0.953)].

CONCLUSIONS
Our results demonstrated that a web-based calculator including age, sex, AFP, and PIVKA-II accurately predicted the presence of HCC in patients with CHB.

ClinicalTrials.gov Identifier
NCT03047603