bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Treatment Strategies for Malignant Gliomas
Authors: Avgeropoulos Nicholas G. , Batchelor Tracy T. 
Published: February 2020

AbstractAlthough survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT-11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligonucleotides, gene therapy, and angiogenesis inhibitors, are also being evaluated in clinical trials. Delivery strategies have been developed to overcome challenges presented by the blood-brain barrier. These noteworthy treatments, alone or in combination, may ultimately prolong survival and enhance quality of life in this group of patients.
Cancers in Children Infected With the Human Immunodeficiency Virus
Authors: Mueller Brigitta U. 
Published: February 2020

Abstract
The AIDS epidemic continues unabated in Africa, Asia, and South America, and since patients survive longer, the number of chronically immunocompromised individuals is increasing in Europe and the United States. The number of children with HIV infection who will ultimately develop a malignancy is not known. Currently, tumors represent about 2% of the AIDS-defining events in children in the United States, but the incidence might be different in developing countries. The most common tumors in HIV-infected children are non-Hodgkin's lymphoma, smooth muscle tumors (leiomyosarcomas), and Kaposi's sarcoma (only in Africa). This article provides an overview of epidemiology and clinical and pathological presentations, as well as preliminary data regarding treatment options in children with HIV-associated malignancies.
Chronic Lymphocytic Leukemia
Authors: Kalil Nelson , Cheson Bruce D. 
Published: February 2020

AbstractThe diagnosis and management of chronic lymphocytic leukemia (CLL) is reviewed, including the basic aspects of epidemiology, molecular biology, and cytogenetics with clinical relevance. The importance of immunophenotype in the differential diagnosis of other lymphoproliferative disorders related to CLL, staging, prognostic factors, promising new drugs, and approaches is summarized.
T-Cell Immunodeficiency Following Cytotoxic Antineoplastic Therapy: A Review
Authors: Mackall Crystal L. 
Published: February 2020

AbstractAlthough cancer itself is immunosuppressive, cytotoxic antineoplastic therapy is the primary contributor to the clinical immunodeficiency observed in cancer patients. The immunodeficiency induced by cytotoxic antineoplastic therapy is primarily related to T-cell depletion, with CD4 depletion generally more severe than CD8 depletion. Myeloablative therapy, dose-intensive alkylating agents, purine nucleoside analogs, and corticosteroids substantially increase the risk of therapy-induced immunosuppression. Restoration of T-cell populations following cytotoxic antineoplastic therapy is a complex process. Efficient recovery of CD4+ T cell populations requires thymic-dependent pathways which undergo an age-dependent decline resulting in prolonged CD4+ T-cell depletion in adults following T-cell-depleting therapy. Total CD8+ T-cell numbers recover in both children and adults relatively quickly post-therapy; however, CD8+ subset disruptions often remain for a prolonged period. The clinical management of patients with therapy-induced T-cell depletion involves the maintenance of a high index of suspicion for opportunistic pathogens, irradiation of blood products, prophylaxis for viral infections, and reimmunization in selected clinical circumstances. Future research avenues include efforts to rapidly rebuild immunity following cytotoxic antineoplastic therapy so that immune-based therapies may be utilized immediately following cytotoxic therapy to target minimal residual neoplastic disease.
Single-Agent Paclitaxel in the Treatment of Advanced Non-Small Cell Lung Cancer
Authors: Socinski Mark A. 
Published: February 2020

Abstract
Paclitaxel was the first identified member of a new class of anticancer drugs known as the taxanes. This compound has significant single-agent activity against a number of solid tumors including nonsmall cell lung cancer (NSCLC). In the first-line setting, single-agent paclitaxel has been studied on a number of different schedules and dose levels. Initial studies were done on the 24-h infusion schedule with doses of 200-250 mg/m2. Response rates were 21%-24%. Median survival ranged from six to nine months with one-year survival rates of 38%-42%. The major toxicity of this infusion schedule was myelosuppression, mainly neutropenia. Subsequent single-agent studies employed shorter infusion durations (three hours), with doses ranging from 175-225 mg/m2. The cumulative experience of the 3-h infusion schedule shows an overall response rate of 28.5% with median survival of 6-11 months and a one-year survival of 37.5%. Similar results were obtained in the one study examining the 1-h infusion schedule with doses ranging from 135-200 mg/m2. The major toxicities of the shorter infusion schedule include neutropenia, neuropathy, and myalgia/arthralgia syndrome. Weekly administration of paclitaxel also showed significant activity in advanced, metastatic NSCLC. Overall response rates have ranged from 30%-56% in the phase I/II setting with one-year survival rates of 42%-53%. A recently completed phase III trial comparing single-agent paclitaxel at 200 mg/m2 over three hours every three weeks to best supportive care (BSC) in advanced or metastatic NSCLC has shown a survival advantage for the single-agent paclitaxel arm (median survival 6.8 months for paclitaxel versus 4.8 months for BSC, p = 0.045). An ongoing phase III trial is comparing single-agent paclitaxel to the combination of carboplatin and paclitaxel (CALGB 9730) in advanced, metastatic NSCLC. Paclitaxel has also been studied in the second-line setting. Infusion schedules have ranged from 1 h, 24 h and 96 h on an every-three-week schedule. Weekly paclitaxel has also been evaluated in the second-line setting. Although the overall experience is limited, response rates have ranged from 0%-38%. The overall role of single-agent paclitaxel in prolonging survival and improving quality of life remains uncertain in this setting.
The cumulative experience of single-agent paclitaxel in advanced, metastatic NSCLC suggests that it is a highly active cytotoxic agent in this setting. The consistent finding of a 35%-40% one-year survival rate is notable. The major toxicities include neutropenia, neuropathy, and myalgia/arthralgia syndrome. Given the overall activity and impact on survival along with an acceptable toxicity profile, single-agent paclitaxel warrants comparison to other active agents and combination regimens in advanced, metastatic NSCLC.
The Comparison of Measurements of the Wrist, Hand and Finger Parameters Between Female and Male
Authors: YOLDAŞ Atila , DEMİR Mehmet , ÇALIŞGAN Elisa , ATAY Emre , GEÇGİL Esin , ÇİÇEK Mustafa , ERTEKİN Tolga , DOĞANER Adem 
Published: February 2020

Objectives: The purpose of this
study was to compare measurements of the wrist, hand
and finger parameters between female and male.Methods:
This randomized trial included 318 healthy participants (n:210 female, n:108 male) aged 25 to 72
years as
a result of examination participated in the study. Tape measure, digital caliper with 0.01 sensitivity used in
the study were obtained at Kahramanmaraş Sütçü
Imam University, Faculty of Medicine, Department
of Anatomy. The measurements taken from
the participants were right and left
wristh circumference, breadth and length,
palm breadth, length and fingers length.Result:
Regarding the scores between female and male, no
statistically significant difference was found between the female and male in
terms of age and body mass index (BMI) parameters (p&gt;0.05). In the
comparison analysis results of the measurements of wrist, hand and finger
parameters in female and male, statistically significant difference was found
in wrist circumference, breadth, length, palm breadth and length, fingers
length. The
points of all parameters of female were significantly lower than male
(p&lt;0.05).

Conclusion:
As
a result of the study, statistically significant
difference was found between female and male in terms of right and left wrist,
hand and finger parameters.
Simulation Model of the Cutting Speed Stabilization System for CNC Metal-Cutting Machine Tools
Authors: Ivanov V. M. 
Published: February 2020

In this paper a simulation model of cutting speed stabilization for numerical control machines was developed. The mode of cutting speed stabilization allows solving a number of technological problems, including the increase in machining productivity and the quality of the part surface, the increase in durability of the cutting tool.Access to the functions of the basic software of CNC systems is limited. Taking this into account, this paper considers the functional and algorithmic features of the power parameter stabilization systems, as the basis for the further development of intelligent algorithmic support and software. The existing guidance on cutting conditions is based on empirical dependencies, the use of which for direct application in algorithms for the cutting process automatic control is difficult, since these dependencies determine the predicted, not the current, parameters. The non-stationary model was adopted as the basic structure of the process of shaping parts, the main non-stationary model parameters are determined by the three-dimensional kinematics of the universal machine. The generalized approach to the power parameter systems and the synthesis of the regulators of their main circuits made it possible to identify the simplest version of the structures based on the use of the regulators with parametric feedback. The functional model contains the main components of the CNC system: an interpolator, servo drives of feeds and main motion, as well as additional cycle and analysis modules. The high-speed processing of end surfaces and the conditions for the implementation of cyclic control tasks are considered. The simulation results confirming the performance of functional algorithms and the possibility of their use in intelligent CNC systems are presented.
PRODUKSI OLAHAN BUNGA ROSELLA (HIBISCUS SABDARIFFA) DI DESA BALONGBENDO KABUPATEN SIDOARJO
Authors: Rohmah Martina Kurnia , Ambari Yani , Wahyuni Khurin In 
Published: February 2020

Keberadaan Rosella belum dimanfaatkan secara optimal padahal tanaman ini memiliki manfaat yang sangat luas dalam bidang pangan dan kesehatan melalui berbagai produk olahan (diversifikasi) karena minimnya pengetahuan dan ketrampilan masyarakat khususny dalam hal pengolahan. Tujuan program ini adalah memberikan pengetahuan, bimbingan, serta pendampingan dalam memanfaatkan bunga rosella menjadi berbagai produk olahan sehingga memiliki nilai ekonomis guna meningkatkan kesejahteraan masyarakat Desa Balongbendo. Metode pelaksanaan yang dilakukan dalam program ini adalah penyuluhan, penanaman tanaman Rosella, pelatihan pembuatan produk olahan bunga rosella, pelatihan pengemasan dan pemasaran produk bunga rosella, serta pendampingan pada pameran produk olahan di Kabupaten Sidoarjo. Hasil dari kegiatan ini adalah: (1) Meningkatnya pengetahuan mitra tentang manfaat, budidaya tanaman, dan diversifikasi produk olahan Rosella (2) Meningkatnya keterampilan mitra dalam mengolah bunga Rosella dengan berbagai produk, (3) Terciptanya produk-produk olahan bunga rosella yang telah dipasarkan dalam bentuk Teh Rosella, Sirup Rosella dan Es Krim Rosella (4) Meningkatnya daya saing msyarakat Desa Balongbendo se-kebupaten Sidoarjo.Kata kunci—Produk Rosella, Teh Rosella, Sirup Rosella, Es Krim Rosella Abstract The existence of Rosella has not been optimally utilized even though this plant has very broad benefits in the field of food and health through a variety of processed products (diversification) because of the lack of knowledge and skills of the community specifically in terms of processing. The purpose of this program is to provide knowledge, guidance, and assistance in utilizing roselle flowers into various processed products so that they have economic value in order to improve the welfare of the people of Balongbendo Village. The method of implementation carried out in this program are: counseling, planting Rosella plants, training in making processed Rosella flower products, training in packaging and marketing of rosella flower products, and assisting at the exhibition of processed products in Sidoarjo Regency. The results of this activity are: (1) Increased knowledge of partners about the benefits, cultivation of plants, and diversification of processed Rosella products (2) Increased partner's skills in processing Rosella flowers with various products, (3) Creation of processed rosella flower products that have been marketed in the form of Rosella Tea, Rosella Syrup and Rosella Ice Cream (4) Increasing the competitiveness of Balongbendo Villages throughout the Sidoarjo Regency.Keywords—Rosella Products, Rosella Tea, Rosella Syrup, Rosella Ice Cream
PASAR DESA DIGITAL BERBASIS WEB SEBAGAI MEDIA PROMOSI BAGI UMKM
Authors: Samodra Joko , Pahlevi Andreas Syah , Hermanto Yon Ade Lose 
Published: February 2020

Permasalahan yang dimiliki pelaku Usaha Kecil Mikro dan Menengah (UMKM) di desa Tunjungtirto kecamatan Singosari Kabupaten Malang yaitu masih menjalankan usahanya dengan sistem tradisional, belum memiliki media promosi dan pemasaran serta belum memiliki ketrampilan yang memadai dalam menggunakan media berbasis web. Tujuan kegiatan ini agar para pelaku usaha memiliki media promosi dan pemasaran yang efektif bagi peningkatan penjualan produknya. Metode pendekatannya adalah pelatihan dan pendampingan dengan konten pembuatan platform ecommerce pasar desa digital berbasis web, fungsi dan fitur media berbasis web, dan memberikan bekal ketrampilan yang memadai tentang cara menggunakan medianya. Hasil pengembangan dan evaluasi kegiatan dapat disimpulkan bahwa terdapat peningkatan pengetahuan dan ketrampilan dalam hal pembuatan, pemanfaatan media berbasis web dengan indikator telah terwujudnya media online dan sekaligus diuji coba untuk kegiatan promosi dan pemasaran produk mereka.Kata kunci—Pasar Desa, Digital, Media Promosi, UMKM Abstract Problems that are owned by Micro and Medium Enterprises (SMEs) in the village of Tunjungtirto, Singosari sub-district, Malang Regency, are still running their business with traditional systems, do not have promotion and marketing media and do not yet have adequate skills in using web-based media. The purpose of this activity is for businesses to have effective promotional and marketing media to increase sales of their products. The approach method is training and mentoring with the content of making web-based digital village market ecommerce platforms, web-based media functions and features, and providing adequate skills on how to use the media. The results of the development and evaluation of activities can be concluded that there is an increase in knowledge and skills in terms of making, using web-based media with indicators that online media have been realized and at the same time being tested for promotional activities and marketing of their products.Keywords—Village Market, Digital, Media Promotion, SMEs
PEMBUATAN MEDIA PEMBELAJARAN BERBASIS POWERPOINT DAN PEMANFAATAN APLIKASI ANDROID UNTUK GURU BAHASA ARAB
Authors: Nurhidayati Nurhidayati , Asrori Imam , Ahsanuddin Mohammad , Dariyadi M. Wahib 
Published: February 2020

Dari segi sarana dan prasarana, 109 MTs di Kabupaten Bojonegoro sudah memiliki sarana-prasarana yang memadai, di beberapa madrasah fasilitas Internet juga telah tersedia, namun dalam penggunaanya belum optimal. Para guru masih sangat jarang yang memanfaatkan komputer itu untuk tujuan peningkatan pembelajaran apalagi menggunakan media pembelajaran berbasis Powerpoint dengan berbagai aplikasinya ,pengabdian ini dilakukan untuk meningkatkan pengetahuan dan meningkatkan keterampilan guru-guru bahasa Arab MTs di Bojonegoro tentang konsep media pembelajaran berbasis powerpoint, materi yang dikembangkan adalah media pembelajaran bahasa Arab dan pembuatan video pembelajaran melalui android, metode yang digunakan adalah pelatihan dan pendampingan. Hasil pelatihan ini menunjukkan bahwa keterampilan para guru cukup meningkat dengan indikator bahwa produk luaran pelatihan telah memenuhi standar media yang menarik serta berpotensi dapat mempercepat pencapaian kompetensi siswa dalam pembelajaran bahasa arab.Kata kunci— Media Pembelajaran, Pembelajaran inovatif, Bahasa Arab, Powerpoint AbstractIn terms of facilities and infrastructure, 109 MTs in Bojonegoro already have adequate infrastructure, in some madrasah Internet facilities are also available, but the use is not optimal yet. Teachers are still very rarely using the computer for the purpose of improving learning especially using Powerpoint-based learning media with a variety of applications, this dedication is done to increase knowledge and improve the skills of Arabic MTs teachers in Bojonegoro about the concept of powerpoint-based learning media, the material developed is a medium for learning Arabic and making learning videos through Android, the method used is training and mentoring. The results of this training show that the skills of teachers have improved considerably with indicators that the training output products have met attractive media standards and can potentially accelerate the achievement of student competencies in learning Arabic.Keywords—Learning Media, Innovative Learning, Arabic, Powerpoint
PENINGKATAN MUTU PRODUK UKM MELALUI SERTIFIKASI JAMINAN PRODUK HALAL
Authors: Istanti Lulu Nurul , Pratikto Heri , Agustina Yuli , Churiyah Madziatul , Basuki Andi 
Published: February 2020

Kegiatan Pengabdian ini bertujuan untuk meningkatkan mutu produk melalui sertifikasi jaminan produk halal dengan memberikan pengetahuan, pemahaman dan pendampingan tentang pentingnya sertifikasi halal pada pelaku Usaha Kecil Menengah (UKM) di Kabupaten Trenggalek. Sesuai edaran LPPOM MUI bahwasannya di tahun 2019 seluruh produk yang berkaitan dengan makan dan minum harus memiliki sertifikasi halal. Hal ini menjadi salah satu tantangan bagi para pelaku UKM dalam memahami tentang arti pentingnya memiliki sertifikasi halal terhadap produk yang dimiliki. Diharapkan dengan adanya kegiatan ini akan menambah wawasan dan pengalaman yang dapat meningkatkan produktivitas dan daya saing bagi pelaku UKM. Kegiatan penyuluhan dilakukan melalui tahapan sosialisasi sampai pendampingan pendaftaran sertifikasi jaminan produk halal secara online pada 150 pelaku UKM yang bergerak di bidang kuliner, restoran, café maupun hotel. Penyuluhan Proses Sertifikasi Jaminan Produk Halal Usaha Kecil Menengah (UKM) yang telah dilakukan dapat dilihat dari antusiasme keikutsertaan UKM Kabupaten Trenggalek dan Peningkatan Pengetahuan dan kesadaran masyarakat serta pengembangan SDM bagi pelaku UKM di Kabupaten Trenggalek terkait jaminan produk halal.Kata kunci—Penyuluhan, Sertifikasi Jaminan Produk Halal, UKM, Kabupaten Trenggalek. AbstractThis Community Service activity aims to improve product quality through halal product assurance certification by providing knowledge, understanding and assistance on the importance of halal certification for Small and Medium Enterprises (SMEs) in Trenggalek Regency. According to the LPPOM MUI circular, in 2019 all products related to food and drink must have halal certification. This has become one of the challenges for SMEs in understanding the importance of having halal certification for their products. It is expected that this activity will add insight and experience that can increase productivity and competitiveness for SMEs. Counseling activities carried out through the stages of socialization to the assistance of online halal product assurance certification registration on 150 SMEs actors engaged in culinary, restaurants, cafes and hotels. Counseling of the Process of Certification of Halal Assurance for Small and Medium Enterprises (SMEs) that has been carried out can be seen from the enthusiasm of SME participation in Trenggalek Regency and the Increased Knowledge and public awareness and HR development for SMEs in Trenggalek Regency related to halal product guarantee.Keywords—Counseling, Halal Product Guarantee Certification, UKM, Trenggalek Regency
Pelatihan Manajemen dan Pembukuan Dasar Bagi IKM Sanan Kota Malang
Authors: Winarno Agung , Agustina Yuli , Wijijayanti Trisetia , Churiyah Madziatul , Subagyo Subagyo 
Published: February 2020

Tujuan dari kegiatan pelatihan manajemen dan pembukuan dasar di IKM Sanan Kota Malang ini adalah memberikan wawasan, pengetahuan, dan pendampingan bagi para pelaku usaha kripik tempe untuk membuat pembukuan sederhana sehingga mampu membuat pembukuan sendiri agar tertib dalam melakukan pencatatan keuangannya sehingga dapat terukur pengeluaran, pemasukannya dan keuntungan yang diperoleh serta dapat mengetahui perkembangan usahanya. Metode yang dilakukan adalah melalui sosialisasi, kegiatan pelatihan dan pendampingan kepada para pelaku usaha sampai dengan pelaku usaha mempraktekkan langsung pembukuannya secara riil. Hasil yang diperoleh dari kegiatan pelatihan ini adalah dapat meningkatkan pengetahuan dan keterampilan wirausaha di dalam membuat pembukuan sedehana sehingga meningkatkan motivasi di dalam bekerja. pelatihan pembukuan sederhana mendapat respon yang positif dan pelaku usaha mendapatkan pengetahuan dan keterampilan mengenai wawasan baru dalam menjalankan usahanya melalui pembukuan/pencatatan keuangan sederhana yang mudah diaplikasikan. Impikasinya adalah melalui pelatihan pembukuan sederhana pelaku usaha IKM Sanan Kota Malang mampu memahami cara berwirausaha yang baik melalui pencatatan keuangan. Kata kunci— IKM Sanan, Malang, Manajemen, Pelatihan, Pembukuan Dasar. Abstract The purpose of basic management and accounting training activities at SMEs Sanan Malang is to provide insights, knowledge and assistance for tempe chip business practitioners to make simple bookkeeping so as to be able to make their own bookkeeping in order to conduct financial records so that measurable expenses can be measured, the income and profits obtained and can find out the development of the business. The method used is through socialization, training activities and mentoring to business actors up to business practitioners directly practicing bookkeeping in real terms. The results obtained from this training activity are able to increase entrepreneur's knowledge and skills in making simple bookkeeping so as to increase motivation in working. simple bookkeeping training gets a positive response and businesses get knowledge and skills about new insights in running their business through simple financial accounting / records that are easily applied. The dream is through simple accounting training for SMEs Sanan Malang entrepreneurs able to understand good ways of entrepreneurship through financial records. Keywords— IKM Sanan, Malang, Management, Training, Basic Acoounting