bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adiponectin as a sepsis biomarker in dogs: Diagnostic and prognostic value
Authors: Torrente Carlos , Manzanilla Edgar G. , Bosch Luis , Villaverde Cecilia , Pastor Josep , Ruiz de Gopegui Rafael , Tvarijonaviciute Asta 
Published: June 2020

AbstractBackgroundAdiponectin (ADPN) is an adipocytokine with insulin‐sensitizing, vascular‐protective, and anti‐inflammatory properties for which concentration changes occur in response to inflammation. Little is known about the regulation of ADPN and the impact of this adipocytokine in septic dogs.ObjectiveWe aimed to assess the diagnostic and prognostic value of ADPN vs other traditional acute‐phase proteins (APPs), such as albumin (ALB), haptoglobin (HPT), fibrinogen (FBG), ferritin (FRT), and C‐reactive protein (CRP) in dogs with naturally acquired sepsis.MethodsThis prospective observational study included 20 dogs with sepsis, 27 with low‐grade systemic inflammation (LGSI), and 18 clinically healthy dogs as controls. For method analyses, plasma samples were obtained from all dogs on admission and then every 24‐48 hours until discharge or death in the septic group.ResultsSeptic dogs had lower ADPN (2.4 ± 0.46 vs 4.5 ± 0.41mg/L, P < .001) dand ALB (17 ± 1 vs 22 ± 0.8g/L, P = .002), and tended to have higher CRP (87 ± 4.8 vs 73 ± 4.1mg/L, P < .079) concentrations than dogs with LGSI on admission. Only ADPN and ALB were able to successfully discriminate animals with LGSI from those presenting with sepsis with areas under the curve (AUCs) for the receiver operating characteristic (ROC) curves of 0.811 and 0.789, respectively. In the septic group, ADPN concentration did not differ between survivors and non‐survivors, either on admission or at discharge or death.ConclusionsAlthough plasma ADPN can be used as a reliable negative APP in dogs with sepsis, further studies are warranted to confirm the usefulness of this biomarker in terms of disease progression and recovery.
Demonstration of a Compliant Microspring Array as a Thermal Interface Material for Pluggable Optoelectronic Transceiver Modules
Authors: Cui Jin , Pan Liang , Weibel Justin A. 
Published: June 2020

Abstract
Pluggable optoelectronic transceiver modules are widely used in the fiber-optic communication infrastructure. It is essential to mitigate thermal contact resistance between the high-power optical module and its riding heat sink in order to maintain the required operation temperature. The pluggable nature of the modules requires dry contact thermal interfaces that permit repeated insertion–disconnect cycles under low compression pressures (∼10 to 100 kPa). Conventional wet thermal interface materials (TIM), such as greases, or those that require high compression pressures, are not suitable for pluggable operation. Here, we demonstrate the use of compliant microstructured TIM to enhance the thermal contact conductance between an optical module and its riding heat sink under a low compression pressure (20 kPa). The metallized and polymer-coated structures are able to accommodate the surface nonflatness and microscale roughness of the mating surface while maintaining a high effective thermal conductance across the thickness. This dry contact TIM is demonstrated to maintain reliable thermal performance after 100 plug-in and plug-out cycles while under compression.
Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study
Authors: Knight Marian , Bunch Kathryn , Vousden Nicola , Morris Edward , Simpson Nigel , Gale Chris , O’Brien Patrick , Quigley Maria , Brocklehurst Peter , Kurinczuk Jennifer J 
Published: June 2020

AbstractObjectivesTo describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants.DesignProspective national population based cohort study using the UK Obstetric Surveillance System (UKOSS).SettingAll 194 obstetric units in the UK.Participants427 pregnant women admitted to hospital with confirmed SARS-CoV-2 infection between 1 March 2020 and 14 April 2020.Main outcome measuresIncidence of maternal hospital admission and infant infection. Rates of maternal death, level 3 critical care unit admission, fetal loss, caesarean birth, preterm birth, stillbirth, early neonatal death, and neonatal unit admission.ResultsThe estimated incidence of admission to hospital with confirmed SARS-CoV-2 infection in pregnancy was 4.9 (95% confidence interval 4.5 to 5.4) per 1000 maternities. 233 (56%) pregnant women admitted to hospital with SARS-CoV-2 infection in pregnancy were from black or other ethnic minority groups, 281 (69%) were overweight or obese, 175 (41%) were aged 35 or over, and 145 (34%) had pre-existing comorbidities. 266 (62%) women gave birth or had a pregnancy loss; 196 (73%) gave birth at term. Forty one (10%) women admitted to hospital needed respiratory support, and five (1%) women died. Twelve (5%) of 265 infants tested positive for SARS-CoV-2 RNA, six of them within the first 12 hours after birth.ConclusionsMost pregnant women admitted to hospital with SARS-CoV-2 infection were in the late second or third trimester, supporting guidance for continued social distancing measures in later pregnancy. Most had good outcomes, and transmission of SARS-CoV-2 to infants was uncommon. The high proportion of women from black or minority ethnic groups admitted with infection needs urgent investigation and explanation.Study registrationISRCTN 40092247.
Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study
Authors: Blotière Pierre-Olivier , Miranda Sara , Weill Alain , Mikaeloff Yann , Peyre Hugo , Ramus Franck , Mahmoud Zureik , Coste Joël , Dray-Spira Rosemary 
Published: June 2020

ObjectivesTo assess the association between prenatal exposure to monotherapy with the antiepileptic drugs (AEDs) most commonly used during pregnancy and the risk of various neurodevelopmental outcomes compared with lamotrigine.DesignNationwide population-based cohort study.SettingFrench national healthcare databases.ParticipantsChildren born alive between 2011 and 2014 and prenatally exposed to AED monotherapy.Primary and secondary outcome measuresOutcomes included neurodevelopmental disorders (NDD), defined by International Classification of Diseases, 10th Revision codes F70-F98—pervasive developmental disorders (PDD, F84) and mental retardation (MR, F70-F79) were studied separately—and visits to speech therapists. The reference group comprised children prenatally exposed to lamotrigine. Children were followed until outcome, loss to follow-up, death or 31 December 2016. We performed inverse probability of treatment weighting analyses using the propensity score, which included maternal and infant characteristics. Hazard ratios (HRs) were calculated using Cox models.ResultsThe cohort comprised 9034 children, 2916 of which were exposed to lamotrigine, 1627 to pregabalin, 1246 to clonazepam, 991 to valproic acid (VPA), 621 to levetiracetam, 502 to carbamazepine, 477 to topiramate, 378 to gabapentin and 143 to oxcarbazepine. None of these AEDs, except VPA, was associated with an increased risk of any of the four neurodevelopmental outcomes investigated. Exposure to VPA was associated with increased risks of NDDs (HR=2.7, 95% CI (1.8 to 4.0)), PDD (HR=4.4 (2.1 to 9.3)), MR (HR=3.1 (1.5 to 6.2)) and visits to speech therapists (HR=1.5 (1.1 to 1.9)), with a dose-response relationship.ConclusionsNo increased risk of any of the neurodevelopmental outcomes investigated in this study was observed with prenatal exposure to levetiracetam, pregabalin, oxcarbazepine, topiramate, gabapentin, clonazepam or carbamazepine, compared with lamotrigine. However, this study corroborates the well-known association between maternal use of VPA during pregnancy and the risk of neurodevelopmental disorders in the offspring. Longer follow-up is necessary to confirm these findings.
Reducing the number of unnecessary biopsies of US-BI-RADS 4a lesions through a deep learning method for residents-in-training: a cross-sectional study
Authors: Zhao Chenyang , Xiao Mengsu , Liu He , Wang Ming , Wang Hongyan , Zhang Jing , Jiang Yuxin , Zhu Qingli 
Published: June 2020

ObjectiveThe aim of the study is to explore the potential value of S-Detect for residents-in-training, a computer-assisted diagnosis system based on deep learning (DL) algorithm.MethodsThe study was designed as a cross-sectional study. Routine breast ultrasound examinations were conducted by an experienced radiologist. The ultrasonic images of the lesions were retrospectively assessed by five residents-in-training according to the Breast Imaging Report and Data System (BI-RADS) lexicon, and a dichotomic classification of the lesions was provided by S-Detect. The diagnostic performances of S-Detect and the five residents were measured and compared using the pathological results as the gold standard. The category 4a lesions assessed by the residents were downgraded to possibly benign as classified by S-Detect. The diagnostic performance of the integrated results was compared with the original results of the residents.ParticipantsA total of 195 focal breast lesions were consecutively enrolled, including 82 malignant lesions and 113 benign lesions.ResultsS-Detect presented higher specificity (77.88%) and area under the curve (AUC) (0.82) than the residents (specificity: 19.47%–48.67%, AUC: 0.62–0.74). A total of 24, 31, 38, 32 and 42 identified as BI-RADS 4a lesions by residents 1, 2, 3, 4 and 5 were downgraded to possibly benign lesions by S-Detect, respectively. Among these downgraded lesions, 24, 28, 35, 30 and 40 lesions were proven to be pathologically benign, respectively. After combining the residents' results with the results of the software in category 4a lesions, the specificity and AUC of the five residents significantly improved (specificity: 46.02%–76.11%, AUC: 0.71–0.85, p<0.001). The intraclass correlation coefficient of the five residents also increased after integration (from 0.480 to 0.643).ConclusionsWith the help of the DL software, the specificity, overall diagnostic performance and interobserver agreement of the residents greatly improved. The software can be used as adjunctive tool for residents-in-training, downgrading 4a lesions to possibly benign and reducing unnecessary biopsies.
Quality of maternal and newborn care in limited-resource settings: a facility-based cross-sectional study in Burkina Faso and Côte d’Ivoire
Authors: Millogo Tieba , Agbre-Yace Marie Laurette , Kourouma Raissa K , Yaméogo W Maurice E , Tano-Kamelan Akoua , Sissoko Fatou Bintou , Koné-Coulibaly Aminata Soltié , Thorson Anna , Kouanda Seni 
Published: June 2020

ObjectiveTo assess and compare the quality of intrapartum and immediate postpartum care across levels of healthcare in Burkina Faso and Côte d’Ivoire using validated process indicators.DesignHealth facility-based cross-sectional study with direct observation of healthcare workers’ practices while caring for mother–newborn pairs during intrapartum and immediate postpartum periods.SettingPrimary healthcare facilities and their corresponding referral hospitals in the Central-North region in Burkina Faso and the Agneby-Tiassa-Mé region in Côte d’Ivoire.ParticipantsHealthcare providers who care for mother–newborn pairs during intrapartum and immediate postpartum periods, the labouring women and their newborns after childbirth.Main outcome measure(s)Adherence to essential best practices (EBPs) at four pause points in each birth event and the overall quality score based on the level of adherence to the set of EBPs observed for a selected pause point.ResultsA total of 532 and 627 labouring women were included in Burkina Faso and Côte d’Ivoire, respectively. Overall, the compliance with EBPs was insufficient at all the four pause points, even though it varied widely from one EBP to another. The adherence was very low with respect to hand hygiene practices: the care provider wore sterile gloves for vaginal examination in only 7.96% cases (95% CI 5.66% to 11.06%) in Burkina Faso and the care provider washed hands before examination in 6.71% cases (95% CI 3.94% to 11.20%) in Côte d’Ivoire. The adherence was very high with respect to thermal management of newborns in both countries (>90%). The overall mean quality scores were consistently higher in referral hospitals in Burkina Faso at all pause points excluding immediate post partum.ConclusionsWomen delivering in healthcare facilities do not always receive proven EBPs needed to prevent poor childbirth outcomes. There is a need for quality improvement interventions.
Shifting, overlapping and expanding use of “precision oncology” terminology: a retrospective literature analysis
Authors: Tran Audrey , Klossner Quiana , Crain Tyler , Prasad Vinay 
Published: June 2020

ImportanceThe terms “personalized oncology” and “precision oncology” have increased in usage and have generated considerable traction in terms of public attention and research funding. To our knowledge, no prior study has as thoroughly documented the use of the “precision oncology” terminology over the last decade.ObjectiveTo determine how the use of the terms “personalized oncology” and “precision oncology” have changed over time.DesignA retrospective literature analysis using two databases (PubMed and Scopus) over 10 years was performed. Manuscripts using either term “personalized oncology” or “precision oncology” were collected. Manuscripts published in 2011, 2013, 2015, 2017 and through 30 June 2019 were pulled for text analysis. Common reasons for exclusion were if the search term appeared in the institution name only, the search term appeared only in keyword or publication title, or the search term was used to justify the relevance or application of research with no clear definition.SettingManuscripts published and catalogued in PubMed or Scopus.ResultsIn our study, we analysed 399 unique manuscripts published over the last decade. Over time, the terminology has shifted from “personalized oncology” to “precision oncology”. Targeted therapy, molecular biomarker-guided tumour profiling and next generation sequencing (ie, “omics-guided tumor profiling”) are the three most common definitions of the term. While these definitions are somewhat overlapping in concept, over the decade we observed an increase in the number of distinct interpretations of “precision oncology”, ranging from structural biology to clinical practice.Conclusions and relevanceWe have observed that the phrase “precision oncology” is shifting, overlapping and expanding in definition. This all-encompassing approach to defining “precision oncology” ironically renders the term imprecise. Our analysis highlights the inherent challenges in defining novel movements in medicine.
Health and financial burden of adverse childhood experiences in England and Wales: a combined primary data study of five surveys
Authors: Hughes Karen , Ford Kat , Kadel Rajendra , Sharp Catherine A , Bellis Mark A 
Published: June 2020

ObjectiveTo estimate the health and financial burden of adverse childhood experiences (ACEs) in England and Wales.DesignThe study combined data from five randomly stratified cross-sectional ACE studies. Population attributable fractions (PAFs) were calculated for major health risks and causes of ill health and applied to disability adjusted life years (DALYs), with financial costs estimated using a modified human capital method.SettingHouseholds in England and Wales.Participants15 285 residents aged 18–69.Outcome measuresThe outcome measures were PAFs for single (1 ACE) and multiple (2–3 and ≥4 ACEs) ACE exposure categories for four health risks (smoking, alcohol use, drug use, high body mass index) and nine causes of ill health (cancer, type 2 diabetes, heart disease, respiratory disease, stroke, violence, anxiety, depression, other mental illness); and annual estimated DALYs and financial costs attributable to ACEs.ResultsCumulative relationships were found between ACEs and risks of all outcomes. For health risks, PAFs for ACEs were highest for drug use (Wales 58.8%, England 52.6%), although ACE-attributable smoking had the highest estimated costs (England and Wales, £7.8 billion). For causes of ill health, PAFs for ACEs were highest for violence (Wales 48.9%, England 43.4%) and mental illness (ranging from 29.1% for anxiety in England to 49.7% for other mental illness in Wales). The greatest ACE-attributable costs were for mental illness (anxiety, depression and other mental illness; England and Wales, £11.2 billion) and cancer (£7.9 billion). Across all outcomes, the total annual ACE-attributable cost was estimated at £42.8 billion. The majority of costs related to exposures to multiple rather than a single ACE (ranging from 71.9% for high body mass index to 98.3% for cancer).ConclusionsACEs impose a substantial societal burden in England and Wales. Policies and practices that prevent ACEs, build resilience and develop trauma-informed services are needed to reduce burden of disease and avoidable service use and financial costs across health and other sectors.
Does delaying discharge from intensive care until after tracheostomy removal affect 30-day mortality? Propensity score matched cohort study
Authors: Vollam Sarah , Harrison David A , Young J Duncan , Watkinson Peter J 
Published: June 2020

ObjectiveTo investigate the short-term mortality effect of discharge from an intensive care unit (ICU) with a tracheostomy in place in comparison to delaying discharge until after tracheostomy removal.DesignA propensity score matched cohort study using data from the TracMan study.SettingSeventy-two UK ICUs taking part in the TracMan study, a randomised controlled trial comparing early tracheostomy (within 4 days of critical care admission) with deferred tracheostomy (after 10 days if still indicated).Participants622 patients who underwent a tracheostomy while in the TracMan study between November 2004 and November 2008. 144 patients left ICU with a tracheostomy. 999 days of observation from 294 patients were included in the control pool.InterventionsWe matched patients discharged with a tracheostomy in place 1:1 with patients who remained in an ICU until either their tracheostomy was removed or they died with the tracheostomy in place. Propensity models were developed according to discharge destination, accounting for likely confounding factors.Primary outcome measureThe primary outcome was 30-day mortality from the matching day. For the ‘discharged with a tracheostomy’ group, this was death within 30 days after the discharge day. For the ‘remained in ICU’ group, this was death within 30 days after the matched day.Results22 (15.3%) patients who left ICU with a tracheostomy died within 30 days compared with 26 (18.1%) who remained in ICU (relative risk 0.98, 95% CI 0.43 to 2.23).ConclusionKeeping patients on an ICU to provide tracheostomy care was not found to affect mortality. Tracheostomy presence may indicate a higher risk of mortality due to underlying diseases and conditions rather than posing a risk in itself.The TracMan trial was registered on the ISRCTN database (ISRCTN28588190).
Prevalence of progressive multifocal leukoencephalopathy (PML) in adults and children with systemic lupus erythematosus
Authors: Kapoor Teja , Mahadeshwar Pooja , Hui-Yuen Joyce , Quinnies Kayla , Tatonetti Nicholas , Gartshteyn Yevgeniya , Guo Cathy , Geraldino-Pardilla Laura , Askanase Anca D 
Published: June 2020

ObjectiveTo define the risk of progressive multifocal leukoencephalopathy (PML) in SLE.MethodsThis is a retrospective observational study to evaluate PML cases in patients with SLE admitted to two large academic hospitals. Using electronic medical record (EMR) data, International Classification of Diseases (ICD) codes identified PML cases among patients with SLE, rheumatoid arthritis (RA) (controls), had renal transplant and with HIV. Medication exposure was reviewed.ResultsA total of 5409 Columbia University Medical Center (CUMC) patients and 2046 Northwell Health patients were identified using one ICD code for SLE. Of 7455 patients, three had an ICD code for PML. On EMR review, however, PML was substantiated in only one fatal SLE case with significant immunosuppressant use and severe lymphopenia (<0.5 cells x 109/L); one patient was evaluated for PML but cerebrospinal fluid (CSF) was negative for JC virus and improved with treatment of central nervous system (CNS) lupus. EMR data were very limited for the third patient and diagnosis could not be confirmed. None of the 13 342 patients with RA ICD codes had PML. Of the 5409 patients with an SLE ICD code at CUMC, 212 also had a renal transplant ICD code, and 83 had concomitant HIV/AIDS. Based on inpatient pharmacy records of 5409 hospitalised patients at CUMC, 59.2% were treated with steroids, and 16.09% with immunosuppressants (7.76% mycophenolate, 3.42% cyclophosphamide, 2.88% azathioprine and 2.03% rituximab). No patients with paediatric SLE (pSLE) (n=538) had PML. The combined prevalence of PML in hospitalised patients with SLE at the two hospitals was 13–27/100 000 patients.ConclusionAmong 7455 adult patients with SLE ICD codes, there were two PML cases, with only one confirmed case associated with severe lymphopenia and immunosuppressants, corresponding to a prevalence of 13–27 per 100 000 patients. No PML cases in pSLE were found. A high index of suspicion in patients with SLE and CNS manifestations is required for the prompt diagnosis of PML.
Addendum to: Emerging patterns of New Physics with and without Lepton Flavour Universal contributions
Authors: Algueró Marcel , Capdevila Bernat , Crivellin Andreas , Descotes-Genon Sébastien , Masjuan Pere , Matias Joaquim , Novoa-Brunet Martín , Virto Javier 
Published: June 2020

AbstractThis paper is an addendum to Ref. Eur. Phys. J. C79 (2019) no. 8, 714 that supersedes all results (Tables and Figures) in that paper after including the new data on the $$B\rightarrow K^*\mu \mu $$B→K∗μμ angular distribution released in 2020 by the LHCb collaboration. The new results confirm all the conclusions in Eur. Phys. J. C79 (2019) no. 8, 714, exhibiting an increase in the coherence and significance of the hypotheses and confirming the existence of a puzzle.