bluuebunny/crossref_metadata_2025_split huggingface dataset:
An excess radio signal in the Abell 4038 cluster
Authors: Chan Man Ho , Lee Chak Man 
Published: September 2020

ABSTRACT
In the past decade, various instruments, such as the Large Area Telescope (LAT) on the Fermi Gamma Ray Space Telescope, the Alpha Magnetic Spectrometer (AMS) and the Dark Matter Particle Explorer(DAMPE), have been used to detect the signals of annihilating dark matter in our Galaxy. Although some excesses of gamma rays, antiprotons and electrons/positrons have been reported and are claimed to be dark matter signals, the uncertainties of the contributions of Galactic pulsars are still too large to confirm the claims. In this paper, we report on a possible radio signal of annihilating dark matter manifested in the archival radio continuum spectral data of the Abell 4038 cluster. By assuming a thermal annihilation cross-section and comparing the dark matter annihilation model with the null hypothesis (cosmic ray emission without dark matter annihilation), we obtain very large test statistic (TS) values, TS &gt; 45, for four popular annihilation channels, which correspond to more than 6σ statistical preference. This reveals a possible potential signal of annihilating dark matter. In particular, our results are also consistent with the recent claims of dark matter mass, m ≈ 30–50 GeV, annihilating via the $\rm b\bar{b}$ quark channel with the thermal annihilation cross-section. However, at this time, we cannot exclude the possibility that a better background cosmic ray model could explain the spectral data without recourse to dark matter annihilations.
On the partial eruption of a bifurcated solar filament structure
Authors: Monga Aabha , Sharma Rahul , Liu Jiajia , Cid Consuelo , Uddin Wahab , Chandra Ramesh , Erdélyi Robertus 
Published: September 2020

ABSTRACT
The partial eruption of a filament channel with bifurcated substructures is investigated using data sets obtained from both ground-based and space-borne facilities. Small-scale flux reconnection/cancellation events in the region triggered the pile-up of ambient magnetic field, observed as bright extreme ultraviolet (EUV) loops in close proximity to the filament channel. This led to the formation of a V-shaped cusp structure at the site of interaction between the coalesced EUV loops and the filament channel, with the presence of distinct plasmoid structures and associated bidirectional flows. Analysis of imaging data from SDO/AIA further suggests vertical splitting of the filament structure into two substructures. The perturbed upper branch of the filament structure rose up and erupted with the onset of an energetic GOES M1.4 flare at 04:30 ut on 2015 January 28. The estimated twist number and squashing factor obtained from non-linear force free-field extrapolation of the magnetic field data support the vertical split in the filament structure with high twist in the upper substructure. The loss in equilibrium of the upper branch due to torus instability implies that this is a potential triggering mechanism for the observed partial eruption.
A quantitative demonstration that stellar feedback locally regulates galaxy growth
Authors: Zaragoza-Cardiel Javier , Fritz Jacopo , Aretxaga Itziar , Mayya Yalia D , Rosa-González Daniel , Beckman John E , Bruzual Gustavo , Charlot Stephane 
Published: September 2020

ABSTRACT
We have applied stellar population synthesis to 500-pc-sized regions in a sample of 102 galaxy discs observed with the MUSE spectrograph. We derived the star formation history and analyse specifically the ‘recent’ ($20\,\rm {Myr}$) and ‘past’ ($570\,\rm {Myr}$) age bins. Using a star formation self-regulator model, we can derive local mass-loading factors, η for specific regions, and find that this factor depends on the local stellar mass surface density, Σ*, in agreement with the predictions form hydrodynamical simulations including supernova feedback. We integrate the local η–Σ* relation using the stellar mass surface density profiles from the Spitzer Survey of Stellar Structure in Galaxies (S4G) to derive global mass-loading factors, ηG, as a function of stellar mass, M*. The ηG–M* relation found is in very good agreement with hydrodynamical cosmological zoom-in galaxy simulations. The method developed here offers a powerful way of testing different implementations of stellar feedback, to check on how realistic are their predictions.
A Truncated Singleton NLR Causes Hybrid Necrosis inArabidopsis thaliana
Authors: Barragan Ana Cristina , Collenberg Maximilian , Wang Jinge , Lee Rachelle R Q , Cher Wei Yuan , Rabanal Fernando A , Ashkenazy Haim , Weigel Detlef , Chae Eunyoung 
Published: September 2020

AbstractHybrid necrosis in plants arises from conflict between divergent alleles of immunity genes contributed by different parents, resulting in autoimmunity. We investigate a severe hybrid necrosis case in Arabidopsis thaliana, where the hybrid does not develop past the cotyledon stage and dies 3 weeks after sowing. Massive transcriptional changes take place in the hybrid, including the upregulation of most NLR (nucleotide-binding site leucine-rich repeat) disease-resistance genes. This is due to an incompatible interaction between the singleton TIR-NLR gene DANGEROUS MIX 10 (DM10), which was recently relocated from a larger NLR cluster, and an unlinked locus, DANGEROUS MIX 11 (DM11). There are multiple DM10 allelic variants in the global A. thaliana population, several of which have premature stop codons. One of these, which has a truncated LRR–PL (leucine-rich repeat [LRR]–post-LRR) region, corresponds to the DM10 risk allele. The DM10 locus and the adjacent genomic region in the risk allele carriers are highly differentiated from those in the nonrisk carriers in the global A. thaliana population, suggesting that this allele became geographically widespread only relatively recently. The DM11 risk allele is much rarer and found only in two accessions from southwestern Spain—a region from which the DM10 risk haplotype is absent—indicating that the ranges of DM10 and DM11 risk alleles may be nonoverlapping.
Chromosome-Scale Genome Assemblies of Aphids Reveal Extensively Rearranged Autosomes and Long-Term Conservation of the X Chromosome
Authors: Mathers Thomas C , Wouters Roland H M , Mugford Sam T , Swarbreck David , van Oosterhout Cock , Hogenhout Saskia A 
Published: September 2020

AbstractChromosome rearrangements are arguably the most dramatic type of mutations, often leading to rapid evolution and speciation. However, chromosome dynamics have only been studied at the sequence level in a small number of model systems. In insects, Diptera and Lepidoptera have conserved genome structure at the scale of whole chromosomes or chromosome arms. Whether this reflects the diversity of insect genome evolution is questionable given that many species exhibit rapid karyotype evolution. Here, we investigate chromosome evolution in aphids—an important group of hemipteran plant pests—using newly generated chromosome-scale genome assemblies of the green peach aphid (Myzus persicae) and the pea aphid (Acyrthosiphon pisum), and a previously published assembly of the corn-leaf aphid (Rhopalosiphum maidis). We find that aphid autosomes have undergone dramatic reorganization over the last 30 My, to the extent that chromosome homology cannot be determined between aphids from the tribes Macrosiphini (Myzus persicae and Acyrthosiphon pisum) and Aphidini (Rhopalosiphum maidis). In contrast, gene content of the aphid sex (X) chromosome remained unchanged despite rapid sequence evolution, low gene expression, and high transposable element load. To test whether rapid evolution of genome structure is a hallmark of Hemiptera, we compared our aphid assemblies with chromosome-scale assemblies of two blood-feeding Hemiptera (Rhodnius prolixus and Triatoma rubrofasciata). Despite being more diverged, the blood-feeding hemipterans have conserved synteny. The exceptional rate of structural evolution of aphid autosomes renders them an important emerging model system for studying the role of large-scale genome rearrangements in evolution.
Unscrambling the oocyte and the egg: clarifying terminology of the female gamete in mammals
Authors: Duncan Francesca E , Schindler Karen , Schultz Richard M , Blengini Cecilia S , Stein Paula , Stricker Stephen A , Wessel Gary M , Williams Carmen J 
Published: September 2020

Abstract
Most reproductive biologists who study female gametes will agree with the 16th century anatomist William Harvey’s doctrine: ‘Ex Ovo Omnia’. This phrase, which literally translates to ‘everything from the egg’, recognizes the centrality of the egg in animal development. Eggs are most impressive cells, capable of supporting development of an entirely new organism following fertilization or parthenogenetic activation. Not so uniformly embraced in the field of reproductive biology is the nomenclature used to refer to the female germ cell. What is an oocyte? What is an egg? Are these terms the same, different, interchangeable? Here we provide functional definitions of the oocyte and egg, and how they can be used in the context of mammalian gamete biology and beyond.
Cheiro-oral-pedal syndrome as the presenting symptom of brainstem cavernous malformation: a case report
Authors: Anamnart Chumpol , Piyapittayanan Siriwan 
Published: September 2020

ABSTRACT
The rare cheiro-oral-pedal syndrome (COPS) is characterized by sensory disturbances around the corner of the mouth, and in the hand and foot of the same side. The causative lesion is located in the thalamocortical projections, thalamus or brainstem and is usually due to ischemic or hemorrhagic stroke. We report a case of a patient with brain stem cavernous malformations presented as pure COPS with additional sensory disturbance in the thorax. We report this case to raise awareness of these very rare syndromes and demonstrate that mildly presenting symptoms can be caused by an underlying devastating condition.
High Thoracic Erector Spinae Plane Block for Arthroscopic Shoulder Surgery: A Randomized Prospective Double-Blind Study
Authors: Ciftci Bahadir , Ekinci Mursel , Gölboyu Birzat Emre , Kapukaya Furkan , Atalay Yunus Oktay , Kuyucu Ersin , Demiraran Yavuz 
Published: September 2020

Abstract

Objective
Moderate to severe pain may occur following arthroscopic shoulder surgery. An erector spinae plane block (ESPB) may be used for painful conditions of the shoulder. The primary hypothesis of this trial is that ultrasound-guided ESPB would provide effective analgesia by reducing opioid consumption. The secondary hypothesis is that ESPB would result in low pain scores and reduce the use of rescue analgesia.

Design
Randomized prospective double-blind study.

Setting
Academic university hospital.

Subjects
Sixty patients aged between 18 and 65 years designated as American Society of Anesthesiologists (ASA) class I or II who underwent unilateral arthroscopic shoulder surgery under general anesthesia were included in the study.

Methods
Patients were equally divided into two groups—either the ESPB group (n=30) or the sham block group (n=30). ESPB was performed with 30 mL 0.25% bupivacaine at the T2 level in the ESPB group and sham block with 30 mL saline at the T2 level in the sham block group. Twenty minutes before the end of the operation, 100 mg tramadol was administered intravenously to the patients. Intravenous ibuprofen 400 mg 3 × 1 was ordered for the patients during the postoperative period. A patient control analgesia device including a dose of 10 µg/mL fentanyl was connected to the patients.

Results
There were no statistical differences between groups in terms of demographical data. Postoperative fentanyl consumption was significantly lower in the ESPB group than in the sham block group (96.66 µg ±105.57 µg and 230 µg ±247.17 µg, respectively) (P=0.009). The need for rescue analgesia was significantly lower in the ESPB group than in the sham block group (26.66 mg ±35.43 mg and 48.5 mg ±35.45 mg, respectively) (P=0.020). Overall, the visual analog scale scores were significantly lower in the ESPB group than in the sham block group.

Conclusions
ESPB may provide effective analgesia treatment following arthroscopic shoulder surgery.
ACTsmart: Guided Smartphone-Delivered Acceptance and Commitment Therapy for Chronic Pain—A Pilot Trial
Authors: Gentili Charlotte , Zetterqvist Vendela , Rickardsson Jenny , Holmström Linda , Simons Laura E , Wicksell Rikard K 
Published: September 2020

Abstract

Background
Acceptance and commitment therapy (ACT) is a behavioral health intervention with strong empirical support for chronic pain but, to date, widespread dissemination is limited. Digital solutions improve access to care and can be integrated into patients’ everyday lives.

Objective
ACTsmart, a guided smartphone-delivered ACT intervention, was developed to improve the accessibility of an evidence-based behavioral treatment for chronic pain. In the present study, we evaluated the preliminary efficacy of ACTsmart in adults with chronic pain.

Methods
The study was an open-label pilot trial. The treatment lasted for 8 weeks, and participants completed all outcome measures at pretreatment and posttreatment and at 3-, 6-, and 12-month follow-ups, with weekly assessments of selected measures during treatment. The primary outcome was pain interference. The secondary outcomes were psychological flexibility, values, insomnia, anxiety, depressive symptoms, health-related quality of life, and pain intensity. All outcomes were analyzed using linear mixed-effects models.

Results
The sample consisted of 34 adults (88% women) with long-standing chronic pain (M=20.4 years, SD=11.7). Compliance to treatment was high, and at the end of treatment, we observed a significant improvement in the primary outcome of pain interference (d = –1.01). All secondary outcomes significantly improved from pretreatment to posttreatment with small to large effect sizes. Improvements were maintained throughout 12 months of follow-up.

Conclusion
The results of this pilot study provide preliminary support for ACTsmart as an accessible and effective behavioral health treatment for adults with chronic pain and warrant a randomized controlled trial to further evaluate the efficacy of the intervention.
Dialectical Pain Management: Feasibility of a Hybrid Third-Wave Cognitive Behavioral Therapy Approach for Adults Receiving Opioids for Chronic Pain
Authors: Barrett Deborah , Brintz Carrie E , Zaski Amanda M , Edlund Mark J 
Published: September 2020

Abstract

Objectives
This study evaluated the feasibility, acceptability, and potential effectiveness of a hybrid skills-based group intervention, dialectical pain management (DPM), for adults with chronic pain who are receiving long-term opioid therapy. DPM adapts dialectical behavior therapy, a rigorous psychotherapeutic approach to emotion dysregulation, to treat disorders of physiological dysregulation.

Methods
Individuals with chronic pain (N = 17) participated in one of two 8-week DPM intervention cohorts. At pre-test and post-test, participants completed quantitative self-report assessments measuring pain intensity and interference, depressive symptoms, pain acceptance, beliefs about pain medications, and global rating of change. Within 2 weeks after the intervention, participants completed qualitative interviews to assess participant satisfaction and obtain feedback about specific intervention components.

Results
Of the 17 enrolled, 15 participants completed the group with 12 (70%) attending six or more sessions. Participants reported high satisfaction with the intervention. Preliminary findings suggested a significant increase in pain acceptance and a significant reduction in depressive symptoms. Participants also reported an improved relationship with their pain conditions and increased flexibility in responding to pain and applying coping skills. Several participants showed a reduction in opioid dosage over the course of the intervention.

Discussion
Findings support that DPM is a feasible and well-received intervention for individuals with chronic pain. Additional research with a control group is needed to further determine the intervention’s efficacy and impact.
Towards developing diagnostic criteria for early knee osteoarthritis: data from the CHECK study
Authors: Runhaar J , Kloppenburg M , Boers M , Bijlsma J W J , Bierma-Zeinstra S M A ,   and the CREDO expert group
Published: September 2020

Abstract

Objectives
There is a general consensus that a shift in focus towards early diagnosis and treatment of knee OA is warranted. However, there are no validated and widely accepted diagnostic criteria for early knee OA available. The current study aimed to take the first steps towards developing diagnostic criteria for early knee OA.

Methods
Data of 761 individuals with 1185 symptomatic knees at baseline were selected from the CHECK study. For CHECK, individuals with pain/stiffness of the knee, aged 45–65 years, who had no prior consultation or a first consultation with the general practitioner for these symptoms in the past 6 months were recruited and followed for 10 years. A group of 36 experts (17 general practitioners and 19 secondary care physicians) evaluated the medical records in pairs to diagnose the presence of clinically relevant knee OA 5–10 years after enrolment. A backward selection methods was used to create predictive models based on pre-defined baseline factors from history taking, physical examination, radiography and blood testing, using the experts’ diagnoses as gold standard outcome.

Results
Prevalence of clinically relevant knee OA during follow-up was 37%. Created models contained 7–11 baseline factors and obtained an area under the curve between 0.746 (0.002) and 0.764 (0.002).

Conclusion
The obtained diagnostic models for early knee OA had ‘fair’ predictive ability in individuals presenting with knee pain in primary care. Further modelling and validation of the identified predictive factors is required to obtain clinically feasible and relevant diagnostic criteria for early knee OA.
INDOOR RADON MEASUREMENTS FOR THE SOUTH AFRICAN WEST COAST PENINSULA
Authors: le Roux Rikus , Bezuidenhout Jacques , Smit Hennie 
Published: September 2020

Abstract
Granite commonly contains high concentrations of uranium, with consequent high exhalation of radon. The geology of the West Coast peninsula of South Africa is dominated by granite, and a recent article predicted potentially high indoor radon concentrations in this region’s two largest towns, Vredenburg and Saldanha. This research aimed to measure indoor radon levels in these towns. Measurements were first done for a minimum of 3 d during warmer months, with houses typically being more ventilated. Thirty-four homes in Vredenburg and 27 in Saldanha were measured, and the average indoor radon determined to be 40 and 58 Bq m−3, respectively. The measurements were then repeated during the colder months, and an increase in average radon concentration of 173 Bq m−3 for Saldanha and 153 Bq m−3 for Vredenburg was found. The granite geology and lifestyle of occupants during the colder months seem to contribute towards elevated levels of indoor radon concentrations.
ESTABLISHING LOCAL AND NATIONAL DIAGNOSTIC AND INTERVENTIONAL CARDIOLOGY AND RADIOLOGY REFERENCE LEVELS IN A SMALL EUROPEAN STATE: THE CASE OF MALTA
Authors: Pace Eric , Cortis Kelvin , Debono Joseph , Grech Marvin , Caruana Carmel J 
Published: September 2020

Abstract
European Directive 2013/59/EURATOM requires the establishment and use of diagnostic reference levels (DRLs) for diagnostic and interventional procedures. The purpose of this study was to establish local DRLs for a major tertiary public hospital. As the hospital is the only such hospital in Malta, the same data collected for setting local DRLs can also be used for setting national DRLs, making local DRLs de facto national DRLs. A retrospective survey of cumulative kerma-area product (KAP) and fluoroscopy time data from the cardiac catheterisation laboratory and interventional radiology suites was carried out. The effect of system upgrades on cumulative KAP was also assessed. Local DRLs were set for common cardiology and interventional radiology procedures. All DRLs compare favourably with those in European literature. A Philips Allura Clarity upgrade to the cardiac catheterisation laboratories led to significant reductions in cumulative KAP (p ≪  0.05) for most procedures.
The evening light environment in hospitals can be designed to produce less disruptive effects on the circadian system and improve sleep
Authors: Vethe Daniel , Scott Jan , Engstrøm Morten , Salvesen Øyvind , Sand Trond , Olsen Alexander , Morken Gunnar , Heglum Hanne S , Kjørstad Kaia , Faaland Patrick M , Vestergaard Cecilie L , Langsrud Knut , Kallestad Håvard 
Published: September 2020

AbstractStudy ObjectivesBlue-depleted lighting reduces the disruptive effects of evening artificial light on the circadian system in laboratory experiments, but this has not yet been shown in naturalistic settings. The aim of the current study was to test the effects of residing in an evening blue-depleted light environment on melatonin levels, sleep, neurocognitive arousal, sleepiness, and potential side effects.MethodsThe study was undertaken in a new psychiatric hospital unit where dynamic light sources were installed. All light sources in all rooms were blue-depleted in one half of the unit between 06:30 pm and 07:00 am (melanopic lux range: 7–21, melanopic equivalent daylight illuminance [M-EDI] range: 6–19, photopic lux range: 55–124), whereas the other had standard lighting (melanopic lux range: 30–70, M-EDI range: 27–63, photopic lux range: 64–136), but was otherwise identical. A total of 12 healthy adults resided for 5 days in each light environment (LE) in a randomized cross-over trial.ResultsMelatonin levels were less suppressed in the blue-depleted LE (15%) compared with the normal LE (45%; p = 0.011). Dim light melatonin onset was phase-advanced more (1:20 h) after residing in the blue-depleted LE than after the normal LE (0:46 h; p = 0.008). Total sleep time was 8.1 min longer (p = 0.032), rapid eye movement sleep 13.9 min longer (p &lt; 0.001), and neurocognitive arousal was lower (p = 0.042) in the blue-depleted LE. There were no significant differences in subjective sleepiness (p = 0.16) or side effects (p = 0.09).ConclusionsIt is possible to create an evening LE that has an impact on the circadian system and sleep without serious side effects. This demonstrates the feasibility and potential benefits of designing buildings or hospital units according to chronobiological principles and provide a basis for studies in both nonclinical and clinical populations.
41st Annual North American Meeting of the Society for Medical Decision Making; October 21, 2019; Portland, Oregon. Keynote Address: The More Who Die, the Less We Care: Confronting the Deadly Arithmetic of Compassion
Authors: Slovic Paul 
Published: September 2020

(Abstracted from MDM Policy Pract 2020;5(1):2381468320914310. doi: 10.1177/2381468320914310)
Dr Slovic, a psychologist at the University of Oregon, has devoted his research career to this topic. He is a member of the National Academy of Arts and Sciences.