bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel self-assembling peptide for hemostasis during endoscopic submucosal dissection: a randomized controlled trial
Authors: Subramaniam Sharmila , Kandiah Kesavan , Chedgy Fergus , Fogg Carole , Thayalasekaran Sreedhari , Alkandari Asma , Baker-Moffatt Michelle , Dash Joanne , Lyons-Amos Mark , Longcroft-Wheaton Gaius , Brown James , Bhandari Pradeep 
Published: July 2020

Abstract
Background Endoscopic submucosal dissection (ESD) is associated with a risk of bleeding. Bleeding is usually treated with diathermy, although this does carry a risk of mucosal thermal injury. Purastat is a topical hemostat that may be effective in controlling bleeding during ESD, thereby reducing the use of heat therapy. The aim of this study was to assess the reduction in heat therapy used in the interventional group (Purastat) compared with the control group. The secondary aims were to compare the procedure length, time for hemostasis, delayed bleeding rate, adverse events, and wound healing between the groups.
Methods This was a single-center randomized controlled trial of 101 patients undergoing ESD. Participants were randomized to a control group where diathermy was used to control bleeding or an interventional group where Purastat could be used. Follow-up endoscopy was performed at 4 weeks to assess wound healing.
Results There was a significant reduction in the use of heat therapy for intraprocedural hemostasis in the interventional group compared with controls (49.3 % vs. 99.6 %, P < 0.001). There were no significant differences in the procedure length, time for hemostasis, and delayed bleeding rate between the groups. Complete wound healing at 4 weeks was noted in 48.8 % of patients in the interventional group compared with 25.0 % of controls (P = 0.02).
Conclusions This study has demonstrated that Purastat is an effective hemostat that can reduce the need for heat therapy for bleeding during ESD. It may also have a role in improving post-resection wound healing.
Prevalence and Impact of Coagulation Dysfunction in COVID-19 in China: A Meta-Analysis
Authors: Jin Shanen , Jin Yiyang , Xu Bai , Hong Jun , Yang Xianghong 
Published: July 2020

Abstract
Background The aim of this meta-analysis is to assess the prevalence of coagulation dysfunction in Chinese COVID-19 patients and to determine the association of coagulopathy with the severity and prognosis of COVID-19.
Methods A meta-analysis of the prevalence of different abnormal coagulation indicators in COVID-19 patients in China was performed. The difference of coagulation indicators and the incidence of DIC were compared between severe cases and nonsevere cases as well as nonsurvivors and survivors, respectively.
Results A total of 22 Chinese studies involving 4,889 confirmed COVID-19 inpatients were included. The average D-dimer value of COVID-19 patients is 0.67 µg/mL (95% confidence interval [CI]: 0.56–0.78), and 29.3% (95% CI: 20.1–38.5%) of patients showed elevated D-dimer values. Severe patients had significantly higher D-dimer levels and prolonged prothrombin time (PT) compared with nonsevere patients. Nonsurvivors had significantly higher D-dimer levels, prolonged PT, and decreased platelet count compared with survivors. In total, 6.2% (95% CI: 2.6–9.9%) COVID-19 patients were complicated by disseminated intravascular coagulation (DIC), in which the log risk ratio in nonsurvivors was 3.267 (95% CI: 2.191–4.342, Z = 5.95, p < 0.05) compared with that in survivors.
Conclusion The prevalence of coagulopathy in Chinese COVID-19 inpatients is high, and both the abnormal coagulation indicators and DIC are closely associated with the severity and poor prognosis of these COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Closely monitoring of coagulation indicators and application of appropriate anticoagulation may improve the prognosis of COVID-19 inpatients in China.
Developing social and civic competence in secondary education through the implementation and evaluation of teaching units and educational environments
Authors: Fuentes-Moreno Concepcion , Sabariego-Puig Marta , Ambros-Pallarés Alba 
Published: July 2020

AbstractRecent international research in social science teaching highlights difficulties adolescents face when constructing social and citizenship awareness, and their own identity. To shed more light on this process, the present study is framed in the context of social science classrooms, and more specifically around how social and civic competence is developed via particular teaching methodologies and specific learning environments in Spain. The focus is on the analysis of democratic citizenship, as it is commonly accepted in the theoretical and epistemological bases of social sciences that citizenship education is one of the aims of the educational system. The objective of this study is to evaluate the effects of implementing two teaching units on the development of social and civic competence among 110 students in five secondary and high schools in Catalonia. A qualitative observational method is used to identify, describe and analyze the implementation and effects of both teaching units on a hermeneutic-interpretative basis. An ethnographic perspective is used to obtain accounts of education professionals and students. In addition, 19 field notes are analyzed using QSRNVIVO 12 software on two dimensions: citizenship and classroom climate. There are two main findings: first, regarding the formative value of both sequences regarding democratic, active and critical citizenship; the second, regarding the importance of the classroom environment created for this purpose by designing ad hoc learning spaces using active methodologies to contribute to the development of active and responsible citizenship. The conclusions highlight two important issues. The subject of History in secondary education should be vindicated as a key instrument to build democratic awareness, based on the skills of active and critical citizenship. Furthermore, there is a relationship between the development of critical and active citizenship and the creation of learning environments that foster reflection, analysis, interpretation and dialog. The implications of this study pose an important challenge for the study of social sciences. Initial teacher training methodology and syllabi should be reviewed, the importance of the Humanities in our society should be defended, and classrooms and schools should be democratized to promote active participation in citizenship education.
The gain-of-function allele
bamA

E470K

bypasses the essential requirement for BamD in β-barrel outer membrane protein assembly
Authors: Hart Elizabeth M. , Gupta Meera , Wühr Martin , Silhavy Thomas J. 
Published: July 2020

Significance
The assembly of β-barrel outer membrane proteins (OMPs) is broadly conserved in diderm bacteria as well as in mitochondria and chloroplasts. The β-barrel assembly machine (BAM), which assembles OMPs into the outer membrane of gram-negative microbes, contains two essential proteins, BamA and BamD. Here we identify a genetic background in which BamD is nonessential, indicating that BamD does not function in OMP catalysis, but rather plays a regulatory role in OMP assembly. BamD is not conserved in the complexes that assemble OMPs in chloroplasts and mitochondria, likely because these organelles, unlike bacteria, inhabit a carefully controlled cytoplasmic environment.
Vibrational properties of 1D- and 3D polynuclear spin crossover Fe(II) urea-triazoles polymer chains and quantification of intrachain cooperativity
Authors: Wolny Juliusz A , Hochdörffer Tim , Sadashivaiah Sakshath , Auerbach Hendrik , Jenni Kevin , Scherthan Lena , Li Ai-Min , von Malotki Christian , Wille Hans-Christian , Rentschler Eva , Schünemann Volker 
Published: July 2020

Abstract
The vibrational dynamics of the iron centres in 1D and 3D spin crossover Fe(II) 4-alkyl-urea triazole chains have been investigated by synchrotron based nuclear inelastic scattering. For the 1D system, the partial density of phonon states has been modelled with density functional theory methods. Furthermore, spin dependent iron ligand distances and vibrational modes were obtained. The previously introduced intramolecular cooperativity parameter H
coop (Rackwitz et al, Phys. Chem. Chem. Phys. 2013, 15, 15450) has been determined to −31 kJ mol−1 for [Fe(n-Prtrzu)3(tosylate)2] and to +27 kJ mol−1 for [Fe(n-Prtrzu)3(BF4)2]. The change of sign in H
coop is in line with the incomplete and gradual character of the spin transition for the former as well as with the sharp transition for the latter reported previously (Rentschler and von Malotki, Inorg. Chem., Act. 2008, 361, 3646). This effect can be ascribed to the networks of intramolecular interactions in the second coordination sphere of the polymer chains, depending on the spin state of the iron centres. In addition, we observe a decreased coupling and coherence when comparing the system which displays a sharp spin transition to the system with an incomplete soft transition by analyzing molecular modes involving a movement of the iron centres.
A GPU-accelerated fully 3D OSEM image reconstruction for a high-resolution small animal PET scanner using dual-ended readout detectors
Authors: Zeng Tianyi , Gao Juan , Gao Dongfang , Kuang Zhonghua , Sang Ziru , Wang Xiaohui , Hu Lingzhi , Chen Qun , Chu Xu , Liang Dong , Liu Xin , Yang Yongfeng , Zheng Hairong , Hu Zhanli 
Published: July 2020

Abstract
In this work, a GPU-accelerated fully 3D ordered-subset expectation maximization (OSEM) image reconstruction with point spread function (PSF) modeling was developed for a small animal PET scanner with a long axial field of view (FOV). Dual-ended readout detectors that provided high depth of interaction (DOI) resolution were used for the small animal PET scanner to simultaneously achieve uniform high spatial resolution and high sensitivity. First, we developed a novel sinogram generation method, in which the dimension of the sinogram was determined first and then an event was assigned to a few neighboring sinogram elements by using weights that are inversely proportional to the distance from the measured line of response (LOR) to the LOR of the sinogram elements. System geometric symmetry, precomputation of LOR-driven ray-tracing and texture memory were applied to accelerate the GPU-based reconstruction. We developed a spatially variant PSF model where the PSF parameters were obtained by using point source images measured at 18 positions in the FOV and a spatial invariant PSF model where the PSF parameters were obtained by using only one image measured at the center FOV. The performance of the image reconstruction method was evaluated by using simulated phantom data as well as phantom and in-vivo mouse data acquired on the scanner. The results showed that the proposed reconstruction method provided better spatial resolution, a higher contrast recovery coefficient and lower noise than the OSEM reconstruction and was more than 1000 times faster than the CPU-based reconstruction. The spatially variant PSF model did not result in any spatial resolution improvement compared to the spatial invariant PSF model, and thus, the latter that is much easier to implement in image reconstruction and can be used in a small animal PET scanner using detectors with very high DOI resolution. A whole body 18F-FDG mouse image with high resolution and a high contrast to noise ratio was obtained by using the proposed reconstruction method.
Magnetic control over the zitterbewegung of exciton–polaritons
Authors: Sedov E S , Sedova I E , Arakelian S M , Kavokin A V 
Published: July 2020

Abstract
The effect of the zitterbewegung consisting in trembling of trajectory of propagating particles may, in principle, be found in a variety of physical systems characterized by split kinetic energy dispersion branches. However, in a majority of material systems the effect is too weak to be observable. Specially designed semiconductor heterostructures representing optical microcavities with embedded quantum wells allow observing the zitterbewegung of exciton–polaritons that are optical cavity modes strongly hybridized with excitons in quantum wells. Here we show that external magnetic fields applied in the plane of the microcavity amplify this effect and allow for tuning the amplitude and the period of oscillations of polariton trajectories, thus being a convenient tool of control. These results pave the way towards realization of ballistic polariton transistors based on the spin–orbit effect, conceptually similar to Datta-and-Das transistors.
Physical properties of bulk, defective, 2D and 0D metal halide perovskite semiconductors from a symmetry perspective
Authors: Quarti Claudio , Katan Claudine , Even Jacky 
Published: July 2020

Abstract
Metal halide perovskite-based nanostructures, nanosheets and nanoparticles at the forefront, show attractive optoelectronic properties, suitable for photovoltaics and light emission applications. Achieving a sounded understanding of these basic electronic and optical properties represents therefore a crucial step for the full technological exploitation of this class of semiconductors. The rapidly expanding chemical engineering and their unusual structural diversity is fascinating but also challenging for a rational description on par with those well-known for conventional semiconductors. In this sense, group theory-based symmetry analyses offer a general and rigorous approach to understand the properties of various bulk perovskites and perovskite-based nanostructures. In this work, we review the electronic and optical response of metal halide perovskite semiconductors using symmetry analysis from group theory, recalling the main results for the prototypical cubic Pm-3m lattice of AMX3 bulk perovskites (where A is cation, M metal and X halide), then extending the analysis to three cases of technological interest: AMX3 nanoparticles, A4MX6 isolated octahedra, A2MX4 layered systems, and recently introduced deficient halide perovskites (d-HP). On the basis of symmetry arguments, we will stress analogies and differences in the electronic and optical properties of these materials, as induced by the spatial confinement and dimensionality. Meanwhile, we will take advantage of this analysis to discuss recent results and debates from the literature, as the energetics of dark/bright states in the band-edge exciton fine structure of perovskite nanoparticles and nanosheets. From the present work, we also anticipate that the band-edge exciton fine structure of d-HP does not present optically dark states, in striking contrast to AMX3 nanoparticles and layered perovskites, a fact that can have important consequences on the photophysics of these novel perovskitoids.
A practitioner behaviour change intervention for deprescribing in the hospital setting
Authors: Scott Sion , May Helen , Patel Martyn , Wright David J , Bhattacharya Debi 
Published: July 2020

Abstract

Background
hospital deprescribing trials have demonstrated marginal increases in deprescribing activity that are not sustained beyond the trial period. The hospital deprescribing implementation framework (hDIF) links barriers and enablers of deprescribing in hospital with 44 potential intervention components. This study aimed to support geriatricians and pharmacists to select and characterise hDIF components according to affordability, practicability, effectiveness, acceptability, safety and equity (APEASE) to design a deprescribing intervention in the English hospital setting.

Methods
we convened a modified Nominal Group Technique with a panel of nine geriatricians and pharmacists representing five English hospitals. Panel members selected and characterised intervention components from the hDIF based on the APEASE criteria. We set a consensus threshold of 80% agreement per APEASE criterion in order for the intervention component to be included.

Results
the panel selected five intervention components supporting engagement with deprescribing: an organisational action plan to prioritise deprescribing, two training activities to address pharmacists’ beliefs about negative deprescribing consequences, restructuring pharmacists’ working patterns to facilitate their contribution to deprescribing decisions, and sharing experiences of successfully engaging patients/family in deprescribing conversations to support others to do the same. A sixth component was selected to sustain engagement with deprescribing through measuring and sharing deprescribing activity achieved between teams.

Conclusions
deprescribing interventions targeting geriatricians’ and pharmacists’ behaviour in the English hospital context should include the six characterised components. A component to sustain deprescribing activity is a notable omission from previously reported deprescribing interventions and may explain their failure to maintain efficacy beyond the short-term trial period.
Substantial intraspecific genome size variation in golden-brown algae and its phenotypic consequences
Authors: Čertnerová Dora , Škaloud Pavel 
Published: July 2020

AbstractBackground and AimsWhile nuclear DNA content variation and its phenotypic consequences have been well described for animals, vascular plants and macroalgae, much less about this topic is known regarding unicellular algae and protists in general. The dearth of data is especially pronounced when it comes to intraspecific genome size variation. This study attempts to investigate the extent of intraspecific variability in genome size and its adaptive consequences in a microalgal species.MethodsPropidium iodide flow cytometry was used to estimate the absolute genome size of 131 strains (isolates) of the golden-brown alga Synura petersenii (Chrysophyceae, Stramenopiles), identified by identical internal transcribed spacer (ITS) rDNA barcodes. Cell size, growth rate and genomic GC content were further assessed on a sub-set of strains. Geographic location of 67 sampling sites across the Northern hemisphere was used to extract climatic database data and to evaluate the ecogeographical distribution of genome size diversity.Key ResultsGenome size ranged continuously from 0.97 to 2.02 pg of DNA across the investigated strains. The genome size was positively associated with cell size and negatively associated with growth rate. Bioclim variables were not correlated with genome size variation. No clear trends in the geographical distribution of strains of a particular genome size were detected, and strains of different genome size occasionally coexisted at the same locality. Genomic GC content was significantly associated only with genome size via a quadratic relationship.ConclusionsGenome size variability in S. petersenii was probably triggered by an evolutionary mechanism operating via gradual changes in genome size accompanied by changes in genomic GC content, such as, for example, proliferation of transposable elements. The variation was reflected in cell size and relative growth rate, possibly with adaptive consequences.
Avian Extinctions in an Isolated Tropical Wet-Forest Preserve, Ecuador
Authors: Leck Charles F. 
Published: July 2020

Abstract
The avifauna of a small forest island in lowland Ecuador was surveyed to detect recent extinctions. The 87-ha national forest, at Rio Palenque, has had serious declines in bird species numbers, even within the relatively short period of 1973-78. Among the 170 species of forest-dwelling birds, I found no recent records for 19 species, 25 had been last noted in 1975, and 15 presently have precariously low populations. Attributes of the species that had local extinctions included, in order of importance, large body size (predatory habits), general rarity (specialization), or declining populations throughout their range. Illegal hunting was related to the loss of two species at the preserve. The importance of large refuges is reaffirmed by this study.
Annual Productivity and Its Measurement in a Multi-Brooded Passerine, the Eastern Bluebird
Authors: Pinkowski Benedict C. 
Published: July 2020

Abstract
Breeding and demographic parameters are examined for 434 Eastern Bluebirds (Sialia sialis) attempting 324 nests in southeastern Michigan during 1968-1977. Nesting birds spent an average of 10.4 weeks (63.9% of a 16.2-week season) in the study area. Only 154 (35.5%) of the nesting birds remained for entire breeding seasons; these season-long residents averaged 2.14 nests/season and had a higher success rate (68.4%) and presumably greater productivity (5.6 young · pair−1 · season −1) than other birds because site fidelity depends on nesting success.
Although two seasonal peaks for egg-laying were observed, only 75 of 357 birds (21.0%) successfully raised two broods. Evidence is presented to suggest that birds observed for only part of a season initiated nests at the same rate while in and not in the study area, so that an average annual productivity value of 5.0 young · pair−1 · season −1 is calculated for all nesting birds from the observed success rate (57.1%) and mean length of stay in the area. Estimated average productivity of yearlings (4.3 young · pair−1 · season −1) was lower than that of adults (5.7 young · pair−1 · season −1) although nesting success rates were similar in the two age groups.
Diet and Breeding Seasonality among a Population of Sharp-Tailed Munias, Lonchura striata, in Malaysia
Authors: Avery Michael L. 
Published: July 2020

Abstract
From April 1975 through March 1977, the food habits and breeding seasonality of a population of Sharp-tailed Munias (Lonchura striata) were studied in northwestern peninsular Malaysia. The abundance of munias on the study area varied in accordance with the 6-month rice-growing cycle there. The population peaked in March and September when juvenile birds were most numerous and when rice was most plentiful. Field observations and stomach analyses showed that the munias ate rice and the green filamentous alga, Spirogyra, almost exclusively. The primary periods of algae eating occurred in January and June-August, coinciding with the munias' two peak periods of reproductive activity, as determined by gonadal examination. Apparently munias on the study area ate Spirogyra as a source of protein to enable them to become physiologically ready for breeding, much as othe tropical bird species eat insects. Thus, unlike other species, Sharp-tailed Munias' breeding seasonality is determined by manmade cycles of rice cultivation rather than by natural cycles of rain and insect abundance.
Movements of Adult and Juvenile Bananaquits within a Morph-Ratio Cline
Authors: Wunderle Joseph M. 
Published: July 2020

Abstract
Adult and juvenile Bananaquits (Coereba flaveola) were captured and banded at nine different sites in southern Grenada in August-October 1976, 1977, and 1978. The proportion of black morphs decreased to seaward on Point Saline. The morph-ratio cline was steeper for adults than for juveniles, because juveniles move greater distances than postbreeding adults. Home-range sizes of adults are larger during the dry season than in the wet season, which under some circumstances can bring about temporal changes in the steepness of a cline.