bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-Dimensional Projection-Based Embedded Discrete-Fracture Model for Compositional Simulation of Fractured Reservoirs
Authors: Olorode Olufemi , Wang Bin , Rashid Harun Ur 
Published: June 2020

Summary
Most unconventional oil and gas reservoirs are known to have several natural fractures in different orientations, which are consistent with the prevailing stresses when they were created. The accurate and efficient modeling of natural and hydraulic fractures presents a significant computational challenge. In this work, we show the limitations of the embedded discrete-fracture model (EDFM) and present the first 3D projection-based EDFM (pEDFM) algorithm and compositional simulation studies with realistic fracture networks in a fully 3D space.
The simulation results from this work indicate that the pEDFM presented can model realistic fractured unconventional reservoirs accurately and efficiently. To validate the model, we present some simplistic fracture cases that can be meshed and modeled easily using explicit-fracture modeling in commercial-reservoir simulators. From the cases studied, we observe that using progressively finer grids near the hydraulic-fracture surfaces helps to improve model accuracy because this allows us to capture the sharp pressure drops expected near these fracture surfaces. The simulation results show that, unlike EDFM, the robust pEDFM algorithm presented here is accurate even at the low fracture-conductivity values expected in many of these ubiquitous natural fractures.
In this paper, we present the first full 3D compositional modeling with pEDFM. We demonstrate that our model can accurately and efficiently model multiply fractured horizontal wells in unconventional reservoirs, which have complex networks of thousands of fractures at various orientations.
Efficacy and clinical predictors of response to rTMS treatment in pharmacoresistant obsessive-compulsive disorder (OCD): A retrospective study
Authors: Rostami Reza , Kazemi Reza , Jabbari Arezoo , Madani Azam , Rostami Hosseinreza , Taherpour Mohammad Amin , Molavi Parviz , Jaafari Nematollah , Kuo Min-Fang , Vicario Carmelo M. , Nitsche Michael A. , Salehinejad Mohammad Ali 
Published: June 2020

Abstract
Background: Application of repetitive transcranial magnetic stimulation (rTMS) for treating obsessive-compulsive disorder (OCD) has been promising and approved by the Food and Drug Administration in 2018, but effects differ between patients. Knowledge about clinical predictors of rTMS response may help to increase clinical efficacy but is not available so far. Methods: In a retrospective study, we investigated the efficacy of rTMS over the dorsolateral prefrontal cortex (DLPFC) or supplementary motor area (SMA) in 65 pharmaco-resistant OCD outpatients recruited for rTMS treatment from July 2015 to May 2017. Patients received either SMA rTMS (n = 38) or bilateral DLPFC rTMS (n = 27) in case of reporting higher affective and depressive symptoms in addition to the primary OCD symptoms. OCD symptoms and depression/anxiety states were measured at baseline (before the 1st session) and after the 20th session of rTMS. Additionally, we performed a binary logistic regression analysis on the demographic and clinical variables based on the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) 3-factor and 2-factor models and individual items to investigate potential predictors of rTMS response. Results: Patients’ scores in Y-BOCS and Beck anxiety/depression inventories were significantly decreased following rTMS treatment. 46.2% of all patients responded to rTMS, based on the criterion of at least a 30% reduction in Y-BOCS scores. There was no significant difference between response rates of patients in DLPFC and SMA groups. No significant demographic predictors of rTMS efficacy were identified. The factors “Obsession severity”, “resistance” and “disturbance” and the “Interference due to obsessions” and “resistance against compulsions” items of the Y-BOCS significantly predicted response to rTMS. Conclusions: In patients with less intrusive/interfering thoughts, and low scores in the “obsession severity”, “disturbance”, and “resistance factors, rTMS might have superior effects. Identification of clinical and non-clinical predictors of response is relevant to personalize and adapt rTMS protocols in pharmaco-resistant OCD patients. Interpretation of rTMS efficacy should be done with caution due to the lack of a sham intervention condition.
Comparative cytological and transcriptome analysis reveals high pollen fertility and upregulation of environmentally sensitive genic male sterility genes in neo-tetraploid rice
Authors: Wu Jinwen , Chen Yuanmou , Lin Hong , Chen Yang , Yu Hang , Lu Zijun , Li Xiang , Zhou Hai , Chen Zhixiong , Liu Xiangdong 
Published: June 2020

Abstract
Background: Autotetraploid rice is a useful germplasm for polyploid rice breeding; however, low seed setting is a major hindrance for the utilization of autotetraploid rice. Our previous study demonstrated that neo-tetraploid rice have great yield potential, which is thought to be one effective way to overcome the low fertility of autotetraploid rice. However, there is little known about the cause of high pollen fertility in neo-tetraploid rice. Here, we employed cytology and RNA-seq to study the molecular genetic mechanism of high pollen fertility in neo-tetraploid rice. Results: Cytological observations indicate that H1 displayed high pollen fertility (95.62%), lower percentage of pollen mother cells（PMCs）abnormalities, and stable chromosome configurations during the pollen development process compared with its two parents. RNA-seq analysis detected 440 differentially expressed genes (DEGs) in neo-tetraploid rice compared with its two parents. Of these DEGs, 193 were annotated as pollen fertility-related genes, and 129 (~66.8%) exhibited significant upregulation in neo-tetraploid rice compared with its two parents, including nine cloned genes ( TMS9-1 , TMS5 etc.) that were validated by qRT-PCR and had been demonstrated to be pollen fertility-related genes. We further selected TMS9-1 and TMS5 as the candidate gene and analysed its pollen fertility in neo-tetraploid rice using the CRISPR/Cas9 technique. Significant variations have been detected in pollen fertility value, pollen development process and expression level in H1 and its knock out lines. Conclusion: Our finding provides strong evidence for the regulatory mechanisms of neo-tetraploid rice, and upregulation of pollen fertility-related genes should be associated with high fertility. Moreover, knockout of environmentally sensitive genic male sterility genes in the present study provides the new useful germplasm for polyploidy rice breeding.
Clinical characteristics and time trends of hospitalized methadone exposures s in the United States based on the Toxicology Investigators Consortium (ToxIC) Case Registry: 2010-2017
Authors: Mehrpour Omid , Hoyte Christopher , Amirabadizadeh Alireza , Brent Jeffrey 
Published: June 2020

Abstract
Background: Methadone is well known for its long duration of action and propensity for mortality after an overdose. The present research was aimed at evaluating the clinical manifestations and time trends of methadone exposure in patients in US hospitals.Methods: We queried the American College of Medical Toxicology's Toxicology Investigators Consortium case registry for all cases of methadone exposure between January 1, 2010, and December 31, 2017. The collected information included demographic features, clinical presentations, therapeutic interventions, poisoning type (acute, chronic, or acute on chronic), and the reason(s) for exposure. Descriptive data and relative frequencies were used to investigate the participants' characteristics. Our data analysis was performed using SPSS version 19 and Prism software. The trends and clinical manifestations of methadone poisoning over the time period of the study were specifically investigated.Results: Nine hundred and seventy-three patients who met our inclusion criteria, with a mean age of 41.9 ± 16.6 years (range: 11 months-78 years) were analyzed. Five hundred eighty-two (60.2%) were male. The highest rate of methadone poisoning was observed in 2013. There was an increasing rate of methadone exposures in 2010–2013, followed by a decline in 2014–2017. The most common clinical manifestations in methadone-poisoned patients were coma (48.6%) and respiratory depression (33.6%). The in-hospital mortality rate of methadone poisoning was 1.4%.Conclusion: ToxIC Registry data showed that inpatient methadone exposures enhanced from 2010 to 2013, after which a reduction occurred in the years 2014 to 2017.
Health-related quality of life in women with polycystic ovary syndrome attending to a tertiary hospital in Southeastern Spain: a case-control study.
Authors: Sánchez-Ferrer María L , Adoamnei Evdochia , Prieto-Sánchez María T , Mendiola Jaime , Corbalán-Biyang Shiana , Moñino-García Miriam , Palomar-Rodríguez Joaquín A , Torres-Cantero Alberto M 
Published: June 2020

Abstract
Background: Polycystic ovary syndrome (PCOS) is a chronic condition with symptoms affecting many women at reproductive age and evaluating their health-related quality of Life (HRQoL) is an important issue. Moreover, differences in the HRQoL between women with different PCOS phenotypes have never been analyzed. Therefore, the aim of our study was to compare the HRQoL between women with PCOS -and its phenotypes- and controls attending to a tertiary hospital. Methods: A group of 117 women with PCOS and 153 controls were studied between 2014 and 2016. Controls were women without PCOS attending the gynecological outpatient clinic for routine examinations. Cases were women attending the same setting and diagnosed with PCOS. PCOS diagnose was performed following the Rotterdam Criteria and women were further classified by anovulatory or ovulatory phenotypic subtype. Women underwent physical and gynecological exams and completed health questionnaires including the Short Form-12v2. Eight scales and two component summary scores [Physical (PCS) and Mental (MCS), respectively] were calculated. Bivariate and multivariate analyses were performed to assess differences in HRQoL between women with PCOS and controls. Results: All women with PCOS and anovulatory PCOS presented lower score in PCS compared to controls [mean (95%CI): 53.7 (52.5-54.9) and 52.9 (51.5-54.4) vs. 55.8 (54.8-56.8); p-values<0.01], as well as lower scores for five out of the eight scales (p-values < 0.05) after adjusting by age, body mass index, infertility, educational level and current occupation. No significant differences were observed for the MCS between women with or without PCOS or its phenotypic subtypes. Conclusions: HRQoL was significantly decreased in adult women with PCOS and its anovulatory phenotype compared to controls attending the outpatient clinic of a tertiary hospital. These results may have implications for the clinical practice and suggest the need for specific interventions in women with PCOS.
Landslide Susceptibility Mapping using Statistical Methods in Uatzau Catchment Area, Northwestern Ethiopia
Authors: Wubalem Azemeraw 
Published: June 2020

Abstract
Abstract
Uatzau basin in northwestern Ethiopia is one of the most landslide-prone regions, which characterized by frequent high landslide occurrences causing damages in farmlands, non-cultivated lands, properties, and loss of life. Preparing a Landslide susceptibility mapping is imperative to manage the landslide hazard and reduce damages of properties and loss of lives. GIS-based frequency ratio, information value, and certainty factor methods were applied. The landslide inventory map was prepared from detailed fieldwork and Google Earth imagery interpretation. Thus, 514 landslides were mapped, and out of which 359 (70%) of landslides were randomly selected keeping their spatial distribution to build landslide susceptibility models, while the remaining 155 (30%) of the landslides were used to model validation. In this study, six factors, including lithology, land use/cover, distance to stream, slope gradient, slope aspect, and slope curvature were evaluated. The effects of the landslide factor of slope instability were determined by comparing with landslide inventory raster using the GIS environment. The landslide susceptibility maps of the Uatzau area were categorized into very low, low, moderate, high and very high susceptibility classes. The landslide susceptibility maps of the three models validated by the ROC curve. The results for the area under the curve (AUC) are 88.83% for the frequency ratio model, 87.03% for certainty factor, and 84.83% of information value models, which are indicating very good accuracy in the identification of landslide susceptibility zones of a region. From these resulted maps, it is possible to recommend, the statistical methods (Frequency Ratio, Information Value, and Certainty Factor Methods) are adequate to landslide susceptibility mapping. The landslide susceptibility maps can be used for regional land use planning and landslide hazard mitigation purposes.
Keywords: landslide; susceptibility; Geographic Information System (GIS); certainty factor; frequency ratio; information value; Ethiopia.
Shape Reserved Stereo Matching with Segment-based Cost Aggregation and Dual-path Refinement
Authors: Huang Chih-Shuan , Huang Ya-Han , Chan Din-Yuen , Yang Jar-Ferr 
Published: June 2020

Abstract
Stereo matching is one of the most important topics in computer vision and aims at generating precise depth maps for various smart applications. The major challenge of stereo matching is to suppress inevitable errors occurring in smooth, occluded and discontinuous regions. In this paper, we propose a robust stereo matching system, which is based on segment-based superpixels, to design adaptive matching computation and dual-path refinement. After the selection of matching costs, we suggest the segment-based adaptive support weights for cost aggregation, instead of color similarity and spatial proximity, to achieve precise depth estimation. Then, the proposed dual-path depth refinement, which refers the texture features in a cross-based support region, corrects the inaccurate disparities to successively refine the depth maps with shape reserving. Specially for left-most and right most regions, the segment-based refinement can greatly improve the mismatched disparity holes. The experimental results show that the proposed system achieves higher accurate depth maps than the conventional stereo matching methods.
Agreement between Original and Rasch-Approved Neck Disability Index
Authors: LU ZE , MacDermid Joy C. , Nazari Goris 
Published: June 2020

Abstract
Background: Given the high prevalence of neck pain, the neck disability index (NDI) has been used to evaluate patient status and treatment outcomes. Modified versions were proposed as solutions to measurement deficits in the NDI. However, the original 10-item NDI was scored out of 50 and is still the most frequently administered version. Examining the extent of agreement between traditional and Rasch-based versions using Bland-Altman (B&A) plots will inform our understanding of score differences that might rise from using different versions. Therefore, the objective of current study was to describe the extent of agreement between different versions of NDI.Methods: The current study was a secondary data analysis. The study data was compiled from two prospectively collected data sources. We performed a comprehensive literature search to identify Rasch approved NDI within four databases including Embase, Medline, PubMed, and Google Scholar. Alternate forms and scorings were compared to each other and to the standard NDI. We graphed B&A plots and calculated the mean difference and the 95% limits of agreement (LoA; ±1.96 times the standard deviation).Results: Two Rasch approved alternative versions (8 vs 5 items) were identified from 303 screened publications. We analyzed data from 201 (43 males and 158 females) patients attending community clinics for neck pain. We found that the mean difference was approximately 10% of the total score between the 10-item and 5-item (-4.6 points), whereas the 10-item versus 8-item and 8-item versus 5-item had smaller mean differences (-2.3 points). The B&A plots displayed wider 95% LoA for the agreement between 10-item and 8-item (LoA: -12.0, 7.4) and 5-item (LoA: -14.9, 5.8) compared with the LoA for the 8-item and 5-item (LoA: -7.8, 3.3). Conclusion: Two Rasch-based NDI solutions (8 vs 5 items) which differ in number of items and conceptual construction are available to provide interval level scoring. They both provide scores that are substantially different from the ordinal NDI, which does not provide interval level scoring. Smaller differences between the two Rasch solutions exist and may relate to the items included. Due to the size and unpredictable nature of the bias between measures, they should not be used interchangeably.
The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis
Authors: Maddahi Niloofarsadat , Yarizadeh Habib , Aghamir SeyedMohammad Kazem , Alizadeh Shahab , Yekaninejad MirSaeed , Mirzaei Khadijeh 
Published: June 2020

Abstract
Objective

Inflammation plays a leading role in the pathogenesis of nephrolithiasis. The association of the dietary inflammatory index (DII) with urinary lithogenic factors is unclear. This study aimed to evaluate the relation of DII to urinary risk factors of kidney stones formation.

Results

Of 264 participants, 61.4% (n= 162), 72% (n=190), 74.6% (n=197), 68.6% (n=181), and 80.3% (n=212) had hyperoxaluria, hypercreatininuria, hypercalciuria, hyperuricosuria, hypocitraturia, respectively. There was a significant increasing trajectory in urinary calcium, uric acid, and creatinine as well as a decreasing trend in urinary citrate across tertiles of DII score (all P=≤0.001). After multivariate adjustment for energy intake, age, physical activity and body mass index, high DII scores were associated with elevated odds of having hypercreatininuria (OR=2.80, 95%CI: 1.10-7.12, P trend =0.04), hypercalciuria (OR=7.44, 95%CI: 2.62-21.14, P trend ≤0.001), hyperuricosuria (OR=2.22, 95%CI: 1.001-4.95, P trend =0.05), and hypocitraturia (OR=5.84, 95%CI: 2.14-15.91, P trend ≤0.001). No association was identified between DII and hyperoxaluria.
Enhanced pyruvate metabolism in plastids by overexpression of putative plastidial pyruvate transporter in Phaeodactylum tricornutum
Authors: Seo Seungbeom , Kim Joon , Lee Jun-Woo , Nam Onyou , Chang Kwang Suk , Jin EonSeon 
Published: June 2020

Abstract
Background: The development of microalgal strains for enhanced biomass and biofuel production has received increased attention. Moreover, strain development via metabolic engineering for commercial production is being considered as the most efficient strategy. Pyruvate is an essential metabolite in the cells and plays an essential role in amino acid biosynthesis and de novo fatty acid biosynthesis in plastids. Although pyruvate can be a valuable target for metabolic engineering, its transporters have rarely been studied in microalgae. In this study, we aimed to identify the plastidial pyruvate transporter of Phaeodactylum tricornutum and utilize it for strain development.Results: We identified putative pyruvate transporter localized in the plastid membrane of Phaeodactylum tricornutum. Transformants overexpressing the pyruvate transporter were generated to increase the influx of pyruvate into plastids. Overexpression of a plastidial pyruvate transporter in P. tricornutum resulted in enhanced biomass (13.6% to 21.9%), lipid contents (11% to 30%), and growth (3.3% to 8.0%) compared to those of wild type during one-stage cultivation. Conclusion: To regulate the pyruvate influx and its metabolism in plastids, we generated transformants overexpressing the putative plastidial pyruvate transporter in P. tricornutum. They showed that its overexpression for compartmentalizing pyruvate in plastids could be an attractive strategy for the effective production of biomass and lipids with better growth, via enhanced pyruvate metabolism in plastids.
Quantitative analysis of differentially expressed proteins in psoriasis vulgaris using tandem mass tags and parallel reaction monitoring
Authors: Li Yu , Lin Peng , Wang Siyao , Li shuang , Wang Rui , Yang Lin , Wang Hongmei 
Published: June 2020

Abstract
Background: psoriasis vulgaris (PV) is a chronic autoimmune inflammatory disease with epidermal hyperkeratosis and parakeratosis. Methods: the study was to elucidate the pathogenesis of PV by quantitative proteomic analysis of skin lesion biopsies of PV and healthy tissues with tandem mass tags (TMTs) coupled with liquid chromatography–mass spectrometry (LC-MS)/MS. Results: a total of 4562 differentially expressed proteins (DEPs) between PV lesional tissues (n = 11) and healthy tissues (n = 11) were identified, of which 299 were upregulated and 206 were downregulated using |fold change| > 1.3 as the cutoff threshold. The Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that the DEPs were mainly enriched in the activation of immune cells (drug metabolism pathway, NOD-like pathway, and IL-17 pathway), cell proliferation (ribosomal pathway, DNA replication pathway, and base replication pathway), metabolism-related pathways (fatty acid biosynthesis and metabolism, PPAR pathway, glycerophospholipid metabolism, and cortisol synthesis and breakdown), and glandular secretion (saliva secretion, gastric acid secretion, and pancreatic fluid secretion). Thirteen DEPs that were relatively highly expressed in the drug metabolism pathway were validated with parallel reaction monitoring (PRM), of which MPO, TYMP, IMPDH2, GSTM4, and ALDH3A1 were highly expressed in PV, whereas CES1, MAOB, MGST1, and GSTT1 were less expressed in PV. Conclusions: These findings confirmed that these proteins participate in the drug metabolism-other enzyme pathways and play crucial roles in the activation and proliferation of immune cells in the pathogenesis of PV.
Hospital Incident Command Groups' Performance During Major Incident Simulations: A Prospective Observational Study.
Authors: Murphy Jason Patrick , Kurland Lisa , Rådestad Monica , Rüter Anders 
Published: June 2020

Abstract
Background Hospital incident command groups’ (HICG) performance may have a profound impact on hospital response to major incidents. Previous research has assessed hospital incident command group capacity as opposed to performance and factors associated to performance. The objective was to assess associations between decision-making and staff procedure skills of the hospital incident command group.Methods This was a prospective observational study using performance indicators to assess hospital incident command groups’ decision-making and performance. A total of six hospitals in Stockholm, Sweden, with their respective HICGs participated. Associations between decision-making skills and staff procedure skills during major incident simulations were assessed using measurable performance indicators Results Decision-making skills are correlated to staff procedure skills and overall HICG performance. Proactive decision-making skills had significantly lower means than reactive decision-making skills and are significantly correlated to staff procedure skills.Conclusion There is a significant correlation between decision-making skills and staff procedural skills. Hospital incident command groups’ proactive decision-making abilities tended to be less developed than reactive decision-making abilities. These proactive decision-making skills may be a predictive factor for overall hospital incident command group performance. A lack of proactive decision-making ability may hamper efforts to mitigate the effects of a major incident.