bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS VAKSIN POLIVALEN UNTUK PENGENDALIAN VIBRIOSIS PADA KERAPU TIKUS (Cromileptes altivelis)
Authors: Nitimulyo Kamiso Handoyo , Isnansetyo Alim , Triyanto Triyanto , Murdjani Muhammad , Sholichah Lili 
Published: October 2019

The objective of this research was to know the effectiveness of polyvalen Vibrio vaccine to control vibriosis in humpback grouper (Cromileptes altivelis). The effectiveness of vaccine was evaluated by the survival rate (SR), relative percent survival (RPS), mean time to death (MTD) as well as growth rate of vaccinated fish. This research consisted of 4 treatments (control, injection, immersion, and oral vaccinations) in quadruplicates. Injection vaccination was conducted by intraperitoneal injection of polyvalen vaccine at 107 cells/fish. Immersion vaccination was done by immersing the fishes at 107 cells/ml for 30 minutes. Oral administration of vaccine was also carried out at 107 cells/fish. One week after the first vaccination, second vaccination (booster) was carried out at the same dosage and by the same administration. One week after the second vaccination, fishes were challenged with 3.16x104 cells/fish of Vibrio ordalii 3J by intraperitoneal injection, and reared for 20 days post infection. Results indicated that polyvalen Vibrio vaccine increased SR (P<0.01) up to 100%. Vaccination was also able to delay MTD of fishes. However, the vaccination was not influence the growth rate of fish.
POSSÍVEL RELAÇÃO ENTRE CANDIDÍASE ORAL E CANDIDEMIA EM PACIENTES HOSPITALIZADOS
Authors: Nogueira de Paula Barros Jackeline 
Published: October 2019

RESUMO Candidíase oral é uma doença oportunista frequentemente encontrada em pacientes imunocomprometidos ecandidemia é considerada uma complicação sistêmica, queconfigura como preocupação entre a comunidade científica, principalmente devido as altas taxas de morbimortalidade em pacientes críticos hospitalizados. Assim, o objetivo desse estudo é apresentar, por meio de revisão de literatura narrativa, a possível relação entre candidíase oral e candidemia, na tentativa de contribuição para:o diagnóstico precoce,abordagem terapêutica mais adequada e elaboração de políticas públicas de prevenção mais eficazes, visando melhorar sobrevida e qualidade de vida dos pacientes. Palavras-Chave: Candidíase oral, Candidemia, Unidade Terapia Intensiva. ABSTRACT Oral candidiasis is a common opportunistic disease found in immunocompromised patients and candidemia is considered a systemic complication, which is a concern among the scientific community, mainly due to the high rates of morbidity and mortality in critically ill hospitalized patients. Thus, the objective of this study is to present, through a narrative review of literature, the possible relationship between oral candidiasis and candidemia, in an attempt to contribute to: an earlier diagnosis, more appropriate therapeutic approach and in addition to the elaboration of more effective public prevention policies to improve survival and quality of life of patients. Keywords: Oral candidiasis, Candidemia, Intensive Care Unit
EXTRAÇÃO DE PRÉ-MOLARES - RELATO DE CASO
Authors: Raposo de Assis Martins Victor 
Published: October 2019

Em determinados casos na área da ortodontia é preciso indicar os procedimentos de extração para que se consiga um bom resultado clínico no final do tratamento. O objetivo do presente trabalho é relatar um caso clínico onde o paciente possuía maloclusão classe I de Angle com biprotrusão que teve como parte do tratamento a extração de 4 pré-molares (dentes 14,24,34,44) e mostrar os ótimos resultados com tais procedimentos. O tratamento teve a duração de 4 anos, com um resultado e estabilidade bastante satisfatórios. Descritores: extrações, ortodontia, pré-molares ABSTRACT In certain cases in the area of orthodontics it is necessary to indicate the extraction procedures in order to obtain a good clinical result at the end of the treatment. The objective of the present study was to report a clinical case where the patient had Angle class I malocclusion with biprotrusion that had as part of the treatment the extraction of 4 premolars (teeth 14,24,34,44) and show the excellent results with procedures. The treatment lasted 4 years, with a satisfactory result and stability. Keywords: extractions, orthodontics, premolars
GESTÃO PÚBLICA NA ODONTOLOGIA COM O ADVENTO DO PROGRAMA BRASIL SORRIDENTE
Authors: Spezzia Sérgio 
Published: October 2019

ResumoA instituição no ano de 2004 da nova Política Nacional de Saúde Bucal, intitulada Programa Brasil Sorridente (PBS), trouxe consigo inovação e mudou o quadro odontológico na área de saúde. O objetivo deste artigo foi averiguar a performance da gestão pública odontológica e do PBS no desempenho da assistência à saúde pública odontológica. O PBS trouxe consigo um impacto significativo para alavancar a saúde bucal no Brasil, uma vez que até então não havia pelo governo federal, adoção de medidas satisfatórias para o setor. Os repasses de verba destinados ao custeio da saúde bucal da União para os municípios aumentaram. Constatou-se melhora significativa nos serviços prestados, relacionados a assistência à saúde pública odontológica com a implementação do PBS, comparando-se com a realidade apresentada anteriormente e levando-se em consideração o repasse de verbas escasso de antes.Palavras-chave: Gestão em Saúde. Sistema Único de Saúde. Iniquidade Social. Saúde Bucal. AbstractInstitution in 2004 of the National Oral Health Policy, the Brazilian Smiling Program, brought with it innovation and changed the odontological framework in the health area. The objective of this article was to investigate the performance of public dental management and the Brazilian Smiling Program in the performance of dental public health care. PBS brought with it a significant impact to leverage oral health in Brazil, since until then the federal government had not adopted satisfactory measures for the sector. The onlending of funds destined to the cost of oral health of the Union to the municipalities increased. There was a significant improvement in the services provided, related to dental public health assistance with the implementation of PBS, comparing with the reality presented previously and taking into account the transfer of scarce funds from before.Keywords: Health Management. Unified Health System. Social Inequity. Oral Health.
IMPLICAÇÕES ODONTOLÓGICAS DO BULLYING NA ADOLESCÊNCIA
Authors: Spezzia Sérgio 
Published: October 2019

Resumo Bullying consta de transgressão que envolve muito comumente adolescentes, principalmente em suas escolas, o que impacta desfavoravelmente no funcionamento social, qualidade de vida e no bem estar desses indivíduos. Nessa situação oriunda de desigualdade de poder, desnecessariamente, empreende-se comportamento persistente, dotado de agressividade, visando ocasionar prejuízo moral ou de caráter físico. Existem situações clínicas em que a estética mostra-se prejudicada na saúde bucal, o que pode desencadear ocorrência do bullying. O objetivo da presente pesquisa foi por intermédio de um estudo de revisão bibliográfica investigar como as manifestações clínicas provenientes da saúde bucal repercutem na ocorrência de bullying na adolescência. Comumente repercutem, causando bullying situações que apresentam estética prejudicada ou pobre, tais como: má oclusão; apinhamento dental com overjet e overbite; dentes restaurados com aparência estética ruim ou com cor diferenciada visíveis em região anterior da boca; hipoplasia do esmalte, incluindo outros defeitos ou anomalias que podem ocasionar alteração da cor do esmalte e estética prejudicada; presença de múltiplas lesões de cárie visíveis, comprometendo a aparência física do jovem, dentre outros. Concluiu-se que o papel desempenhado pelo cirurgião dentista é fundamental para a elaboração de um plano de tratamento odontológico adequado com diagnóstico e prognóstico voltados para resolução dos problemas dentários que afligem a estética bucal dos adolescentes vitimados pelo bullying. Palavras-chave: Bullying. Adolescente. Comportamento do Adolescente. Saúde Bucal. Qualidade de Vida. Keywords: Bullying. Adolescent. Adolescent Behavior. Oral Health. Quality of Life.
O EMPREGO DAS RADIOGRAFIAS DIGITAIS EM ODONTOLOGIA
Authors: Spezzia Sérgio 
Published: October 2019

Resumo A técnica radiográfica digital configura uma técnica rápida, simples, segura e objetiva. Dispõem-se de sistemas digitais diretos intrabucais e extrabucais para uso, que empregam dois tipos de receptores, são eles: sensor charge coupled device (CCD) e a placa de fósforo fotoativada ou fotoestimulável, Phosphor Storage Plates (PSP). Existem três métodos para obtenção de radiografias digitais, o método direto, o semi-direto e o indireto, híbrido ou digitalizado. O objetivo deste artigo foi averiguar como procede a utilização das radiografias digitais na prática odontológica. Existem algumas vantagens e algumas desvantagens em optar-se por utilizar radiografias digitais ou convencionais. Concluiu-se que a utilização das radiografias digitais na prática odontológica pode promover alguns benefícios, tanto para os profissionais como para os pacientes por se tratar de uma técnica de rápida execução e que é capaz de racionalizar recursos a nível de custo-efetividade. Palavras-chave: Radiologia. Radiografia Dentária. Diagnóstico. Raios X. Abstract The digital radiographic technique sets up a fast, simple, safe and objective technique. There are direct intraoral and extraoral digital systems for use, which use two types of receivers: sensor charge coupled device (CCD) and photo-activated or photo-stimulating phosphor plate, Phosphor Storage Plates (PSP). There are three methods for obtaining digital radiography, the direct method, the semi-direct method and the indirect method, the hybrid method or the digital method. The purpose of this article was to investigate the use of digital radiographs in dental practice. There are some advantages and some disadvantages in choosing to use digital or conventional radiographs. It was concluded that the use of digital radiographs in dental practice can promote some benefits, both for professionals and patients because it is a fast-performing technique that is capable of rationalizing resources in terms of cost-effectiveness. Keywords: Radiology. Radiography, Dental. Diagnosis. X-Rays.
TRATAMENTO ORTO-CIRÚRGICO DE PACIENTE CLASSE II ESQUELÉTICA: RELATO DE CASO
Authors: Cristina Sartoretto Suelen 
Published: October 2019

RESUMO: A abordagem orto-cirúrgica em pacientes que apresentam Deformidade Dentofacial do tipo Classe II (DDFII) é mandatória para a obtenção de resultados satisfatórios à nível de função, estética e qualidade respiratória. A cirurgia ortognática permite a manipulação em amplitude dos ossos gnáticos como avanço mandibular e impacção maxilar, movimentos normalmente realizados em pacientes portadores de discrepância severa do tipo Classe II. O objetivo do presente trabalho é apresentar um relato de caso clínico de um paciente submetido a cirurgia ortognática para correção de DDFII com importante ganho no que se refere à estética facial, além dos ganhos funcionais, devido à harmonia entre o terço inferior com o restante da face. Palavras-chave: Cirurgia ortognática; Avanço mandibular; Ortodontia. ABSTRACT: The orthosurgical approach in patients with Class II malloclusion is mandatory to obtain satisfactory results in terms of function, aesthetics and respiratory quality. Orthognathic surgery allows manipulation of the gnatic bones such as mandibular advancement and maxillary impaction, movements normally performed in patients with severe Class II discrepancy. The aim of this study is to present a case report of a patient who underwent orthognathic surgery to correct DDFII with significant gains in facial aesthetics, as well as functional gains, due to the harmony between the lower third and the rest of the face. Key words: Ortognatic surgery; Mandibular advancement; Orthodontics
Economic Consequences of Risk Disclosures: Evidence from Crowdfunding
Authors: Madsen Joshua M. , McMullin Jeff L. 
Published: October 2019

ABSTRACT
On September 20, 2012, the rewards-based crowdfunding platform Kickstarter.com added a “risks and challenges” section to all project pages. While the section header became a mandatory part of the platform, discussion of risks within that section is voluntary and unverified, making this setting particularly useful for identifying the effects of disclosure on both crowdfunders and entrepreneurs. Consistent with increased salience of risks, we find that backer support for high-risk projects decreases after the introduction of this section, but that lengthier risk disclosures mitigate this decrease in backer support. Further analysis reveals that creators who provide lengthier risk disclosures also increase other non-risk disclosures, and that these non-risk disclosures are primarily responsible for the increased backer support. Collectively, we provide evidence that the introduction of a voluntary and unverified risk disclosure reduced information asymmetry within this unregulated market.
JEL Classifications: M41; G24; L15; R12; D03.
Would an Audit Judgment Rule Improve Audit Committee Oversight and Audit Quality?
Authors: Kang Yoon Ju , Piercey M. David 
Published: October 2019

SUMMARY
The current regulatory environment encourages auditors to engage in “defensive auditing.” That is, auditors must show that they complied with widely accepted standard procedures in order to reduce their exposure to PCAOB inspectors and courts. This could discourage innovation in auditing, since new and innovative procedures are not standard practice. A new stream of research examines a proposed change to legal rules that would protect auditors from being second-guessed, even when they make non-standard judgments, provided that they are made rigorously and in good faith. This proposed “Audit Judgment Rule” (“AJR”) could potentially improve audit quality by encouraging innovation. We review two studies that examine the effects of such an AJR on the judgments of audit committee members and auditors. Results of these studies suggest that an AJR may have unintended consequences, reducing audit innovation and audit quality. We discuss implications for implementing an AJR, including directions for future research.
Muscle Oxygen Supply and Use in Type 1 Diabetes, From Ambient Air to the Mitochondrial Respiratory Chain: Is There a Limiting Step?
Authors: Heyman Elsa , Daussin Frédéric , Wieczorek Valerie , Caiazzo Robert , Matran Régis , Berthon Phanélie , Aucouturier Julien , Berthoin Serge , Descatoire Aurélien , Leclair Erwan , Marais Gaëlle , Combes Adrien , Fontaine Pierre , Tagougui Sémah 
Published: October 2019

OBJECTIVE
Long before clinical complications of type 1 diabetes (T1D) develop, oxygen supply and use can be altered during activities of daily life. We examined in patients with uncomplicated T1D all steps of the oxygen pathway, from the lungs to the mitochondria, using an integrative ex vivo (muscle biopsies) and in vivo (during exercise) approach.

RESEARCH DESIGN AND METHODS
We compared 16 adults with T1D with 16 strictly matched healthy control subjects. We assessed lung diffusion capacity for carbon monoxide and nitric oxide, exercise-induced changes in arterial O2 content (SaO2, PaO2, hemoglobin), muscle blood volume, and O2 extraction (via near-infrared spectroscopy). We analyzed blood samples for metabolic and hormonal vasoactive moieties and factors that are able to shift the O2-hemoglobin dissociation curve. Mitochondrial oxidative capacities were assessed in permeabilized vastus lateralis muscle fibers.

RESULTS
Lung diffusion capacity and arterial O2 transport were normal in patients with T1D. However, those patients displayed blunted exercise-induced increases in muscle blood volume, despite higher serum insulin, and in O2 extraction, despite higher erythrocyte 2,3-diphosphoglycerate. Although complex I– and complex II–supported mitochondrial respirations were unaltered, complex IV capacity (relative to complex I capacity) was impaired in patients with T1D, and this was even more apparent in those with long-standing diabetes and high HbA1c. O2max was lower in patients with T1D than in the control subjects.

CONCLUSIONS
Early defects in microvascular delivery of blood to skeletal muscle and in complex IV capacity in the mitochondrial respiratory chain may negatively impact aerobic fitness. These findings are clinically relevant considering the main role of skeletal muscle oxidation in whole-body glucose disposal.
Phenolic compounds of Iris adriatica and their antimycobacterial effects
Authors: Ochensberger Sandra , Alperth Fabian , Mitić Božena , Kunert Olaf , Mayer Stefanie , Mourão Maria Ferreira , Turek Ivana , Luca Simon Vlad , Skalicka-Woźniak Krystyna , Maleš Željan , Hruševar Dario , Duka Ivan , Bucar Franz 
Published: October 2019

Abstract
Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc2 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L−1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone, responsible for the resistance-modulatory activity of this plant.
Antiproliferative and genotoxic potential of xanthen-3-one derivatives
Authors: Veljović Elma , Špirtović-Halilović Selma , Muratović Samija , Osmanović Amar , Haverić Sanin , Haverić Anja , Hadžić Maida , Salihović Mirsada , Malenica Maja , Šapčanin Aida , Završnik Davorka 
Published: October 2019

Abstract
Twelve previously synthesized, biologically active 2,6,7-trihydroxyxanthen-3-one derivatives were evaluated in vitro for antiproliferative activity. Compounds were screened against HeLa, SW620, HepG2 and A549 tumor cell lines. Compound with the trifluormethyl group on C-4’ position of the phenyl ring showed the best inhibitory activity towards HeLa and A549 tumor cells with IC
50 of 0.7 and 4.1 µmol L−1, resp. Compound with chlorine and fluorine substituents on aryl ring showed the best antiproliferative activity against SW620 with IC
50 of 4.1 µmol L–1 and against HepG2 tumor cell line with IC
50 of 4.2 µmol L–1. Analyses of cytotoxic and genotoxic potential of the trifluormethyl derivative were performed with cytokinesis-block micronucleus cytome assay in human lymphocyte culture and revealed no genotoxic and cytotoxic effects. The most potent compounds were subjected to molecular docking simulations in order to analyse bindings to molecular targets and, at the same time, further support the results of experimental cytotoxic tests. Docking studies showed sites of importance in forming hydrogen bonds of the most potent compounds with targets of interest.
Antithrombotic activity of flavonoids and polyphenols rich plant species
Authors: Bojić Mirza , Maleš Željan , Antolić Andrea , Babić Ivana , Tomičić Maja 
Published: October 2019

Abstract
Cardiovascular diseases represent one of the most notable health problems of the modern civilization. Stroke and heart attack often lead to lethal outcome; essential problem underneath being thrombus formation. Prophylactic approaches include acetylsalicylic acid and clopidogrel therapy on the level of primary hemostasis, i.e., primary clot formation. In the last five years, in the USA, health care expenses related to cardiovascular diseases have increased 50 %, to over 350 billion dollars. Thus, application of plant species and medicinal plants rich in polyphenols in prevention of thrombus formation are of interest. This is supported by the fact that the number of publications on antiaggregatory effect of polyphenols has doubled in the last decade. In this review we focus on antiaggregatory effect of most abundant polyphenols – flavonoids, the effect of plant extracts rich in polyphenols (propolis, species Salvia sp., Calamintha nepeta L., Lavandula angustifolia Mill., Melissa officinalis L, Mentha x piperita L., Ocimum basilicum L., Origanum vulgare L., Rosmarinus officinalis L.) on platelet aggregation, association of chemical composition and antioxidant properties with the observed biological effect, and possible clinical significance of the published results.
Nutrition – facts and myths
Authors: Verbanac Donatella , Maleš Željan , Barišić Karmela 
Published: October 2019

Abstract
Taking responsibility for your life, among other factors, means also considering what to eat and which nutrition pattern to follow. Everyone needs to think about what they put on the plate and which ingredients should be avoided. Food, as such, will never be a drug or medication, like a painkilling tablet relieving pain in a short amount of time, for example. However, proper nutrition is our ally in the prevention of diseases, maintaining balance in our body and our mind. By following the main principles of a healthy diet, the physiological homeostasis can be managed, as well as faster recovery from disease achieved.
This review is aimed at summarizing basic principles of nutrition recommendations and at empowering stakeholders (pharmacists, medical biochemists, physicians) to be able to communicate to their patients and customers healthy and sustainable nutrition choices through the personalized advice.
Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs
Authors: Torić Jelena , Marković Ana Karković , Brala Cvijeta Jakobušić , Barbarić Monika 
Published: October 2019

Abstract
Cancer presents one of the leading causes of death in the world. Current treatment includes the administration of one or more anticancer drugs, commonly known as chemotherapy. The biggest issue concerning the chemotherapeutics is their toxicity on normal cells and persisting side effects. One approach to the issue is chemoprevention and the other one is the discovery of more effective drugs or drug combinations, including combinations with polyphenols. Olive oil polyphenols (OOPs), especially hydroxytyrosol (HTyr), tyrosol (Tyr) and their derivatives oleuropein (Ole), oleacein and oleocanthal (Oc) express anticancer activity on different cancer models. Recent studies report that phenolic extract of virgin olive oil may be more effective than the individual phenolic compounds. Also, there is a growing body of evidence about the combined treatment of OOPs with various anticancer drugs, such as cisplatin, tamoxifen, doxorubicin and others. These novel approaches may present an advanced strategy in the prevention and treatment of cancer.
In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery
Authors: Dukovski Bisera Jurišić , Bračko Ana , Šare Marija , Pepić Ivan , Lovrić Jasmina 
Published: October 2019

Abstract
Oil-in-water nanoemulsions (NEs) represent one of the formulation approaches to improve eye-related bio-availability of lipophilic drugs. The potential of cationic NEs is pronounced due to the electrostatic interaction of positively charged droplets with negatively charged mucins present in the tear film, providing prolonged formulation residence at the ocular surface. The aim of this study was to develop a cationic ophthalmic NE with cationic lipid stearylamine (SA) as a carrier of a positive charge. The addition of a nonionic surfactant provided the dual electro-steric stabilization of NEs and enabled tuning of SA concentration to achieve an optimal balance between its interaction with mucins and biocompatibility. Physicochemical characterization, stability profile, in vitro mucoadhesion study and biocompatibility study employing 3D HCE-T cell-based model of corneal epithelium pointed out the NE with 0.05 % (m/m) SA as the leading formulation. Minimizing SA content while retaining droplet/mucin interactions is of great importance for efficacy and safety of future ophthalmic drug products.