bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective observational study investigating the factors associated with right heart failure in patients with primary acute pulmonary embolism and deep vein thrombosis
Authors: Kobayashi Satoshi , Muto Makoto , Yabe Hitoshi , Imao Masashi , Okada Yukinori 
Published: March 2020

AbstractBackgroundThe relationship between the risk of right heart failure in primary acute pulmonary embolism after embolization and the residual thrombus sites in the pelvis and lower limbs is not clear.MethodsThis single‐center retrospective observational study examined the results of contrast‐enhanced computed tomography and venous ultrasonography of patients with primary acute PE and DVT. We assessed the association between the occurrence of right heart failure and age; gender; pulmonary thrombosis distribution; most proximal site of deep vein thrombosis in the soleal vein, inferior vena cava (IVC), or common iliac vein (CIV); DVT distribution; and malignancy using univariate and multivariate logistic regression.ResultsIn all, 77 of 165 patients were male (mean age: 65.1 ± 13.7 years). Right heart failure occurred in 53 patients (32.1%). Multivariate analysis revealed that the odds ratio (OR) for right heart failure was significantly lower in patients with the most proximal site of DVT in the IVC/CIV (OR = 0.07, 95% confidence interval [CI] 0.01‐0.62, P = .017), while it was significantly higher in females (OR = 2.51, 95% CI 1.05‐6.01, P = .039), and in patients who exhibited the presence of bilateral venous thrombosis (OR = 3.89, 95% CI 1.60‐9.48, P = .003).ConclusionA significant factor involved in PE without right heart failure was the most proximal site of DVT in the IVC/CIV, and significant risk factors associated with PE with right heart failure were more prevalent in females and in patients who exhibited the presence of bilateral venous thrombosis.
Malignant fibrous histiocytoma of bone: A survival analysis from the National Cancer Database
Authors: Malik Azeem T. , Baek Jae , Alexander John H. , Voskuil Ryan T. , Khan Safdar N. , Scharschmidt Thomas J. 
Published: March 2020

AbstractBackground and ObjectivesMalignant fibrous histiocytoma (MFH) of bone, now known as undifferentiated pleomorphic sarcoma of bone, is a rare neoplasm that accounts for less than 2% of all primary malignant bone tumors. The objective of the current study was to evaluate prognosis and survival for MFH of bone.MethodsThe 2004 to 2016 National Cancer Database was queried to identify patients with a primary MFH of bone. Kaplan‐Meier survival and Cox regression analyses were used to analyze overall survival and risk factors associated with overall mortality.ResultsThe overall 5‐year and 10‐year survival rates were 38.3% and 30.5%, respectively. Increasing stage and metastatic disease at presentation were associated with poor overall survival (P < .001). Patients aged 18 to 50 years (hazard ratio [HR], 0.51), 51 to 75 years (HR, 0.61), and those undergoing surgery (HR, 0.39) had improved survival. Having Medicare insurance (HR, 1.48), residing in a low educated area (HR, 2.56), and positive surgical margins (HR, 1.80) were associated with poor survival.ConclusionsThe overall prognosis of MFH of bone is poor with a reported 5‐year survival rate of 38.3%. Undergoing surgery and younger age were associated with a better prognosis. Older age, having Medicare insurance, and positive surgical margins were predictors of mortality.
Correlation of hyperpolarized 13C‐MRI data with tissue extract measurements
Authors: Lee Casey Y. , Lau Justin Y. C. , Geraghty Benjamin J. , Chen Albert P. , Gu Yi‐Ping , Cunningham Charles H. 
Published: March 2020

Hyperpolarized (HP)
MRI provides the means to monitor lactate metabolism noninvasively in tumours. Since
‐lactate signal levels obtained from HP
imaging depend on multiple factors, such as the rate of
substrate delivery via the vasculature, the expression level of monocarboxylate transporters (MCTs) and lactate dehydrogenase (LDH), and the local lactate pool size, the interpretation of HP
metabolic images remains challenging. In this study, ex vivo tissue extract measurements (i.e., NMR isotopomer analysis, western blot analysis) derived from an MDA‐MB‐231 xenograft model in nude rats were used to test for correlations between the in vivo
data and the ex vivo measures. The lactate‐to‐pyruvate ratio from HP
MRI was strongly correlated with [1‐
]lactate concentration measured from the extracts using NMR (R = 0.69, p
0.05), as well as negatively correlated with tumour wet weight (R =
0.60, p
0.05). In this tumour model, both MCT1 and MCT4 expressions were positively correlated with wet weight (
= 0.78 and 0.93, respectively, p
0.01). Lactate pool size and the lactate‐to‐pyruvate ratio were not significantly correlated.
From Amherst (Massachusetts, USA) to Padua (Italy) and back again: Louis A. Carpino's scientifically productive journey
Authors: Toniolo Claudio , Moretto Alessandro , Formaggio Fernando , Broxterman Quirinus B. , Crisma Marco 
Published: March 2020

AbstractIn this work, we studied and discussed a relevant aspect of peptide science, strictly related to the scientific production of Prof. Louis A. Carpino who passed away in early 2019. Specifically, we carried out a statistical survey on the significant 3D‐structural parameters (bond lengths, bond angles, and torsion angles) of the currently extensively used 9‐fluorenylmethyloxycarbonyl (Fmoc) α‐amino protecting group introduced by Carpino in peptide synthesis. In this compilation, we considered all 131 X‐ray diffraction structures available in the literature on amino acid / linear peptide derivatives and Fmoc‐labeled amines. Both Fmoc secondary and tertiary urethane functionalities were examined and separately analyzed.
Comparative Proteomic Analyses of the Liver in D‐Galactosamine‐Sensitized Mice Treated with Different Toll‐Like Receptor Agonists
Authors: Hao Jun , Qi Tingting , Zhu Xiaoying , Chen Jinjun 
Published: March 2020

AbstractAcute liver failure (ALF) is a severe consequence of abrupt hepatocyte injury and has lethal outcomes. Three toll‐like receptor agonists, including polyinosinic‐polycytidylic acid (poly(I:C)), lipopolysaccharide (LPS), and cytosine‐phosphate‐guanine (CpG) DNA, cause acute and severe hepatitis, respectively, in D‐galactosamine (D‐GalN)‐sensitized mice. However, the molecular differences among three ALF models (LPS/D‐GalN, poly(I:C)/D‐GalN, and CpG DNA/D‐GalN), are unclear. Here, tandem mass tag based quantitative proteomic analyses of three ALF mouse models are performed. 52 common differentially expressed proteins (DEPs) are identified, in three ALF groups, compared to the control. Gene ontology analyses show that among the common DEPs, ten proteins are involved in immune system process, and 39 proteins in metabolic process. Among 80,195, and 23 specifically‐expressed proteins in poly(I:C)/D‐GalN, LPS/D‐GalN, and CpG DNA/D‐GalN groups, LPS/D‐GalN‐specific proteins are mostly distributed in the endoplasmic reticulum and more enriched in metabolic pathways, whereas poly (I:C)/D‐GalN‐specific proteins are mainly in the membrane and CpG DNA/D‐GalN‐specific proteins are related to the ribosome structural composition. In conclusion, the common and specific DEPs in three ALF mouse models at molecular level are identified; and determined a close‐to‐complete reference map of mouse liver proteins which will be useful for clinical diagnosis and treatment of liver failure in humans.
Role of concurrent chemoradiotherapy and stereotactic body radiation treatment for palliation of previously untreated head and neck cancers
Authors: Vengaloor Thomas Toms , Packianathan Satyaseelan , Ahmed Hiba Zarah , Joseph Sanjay , Bhanat Eldrin , Mundra Eswar K , Kuruvilla Teessa Perekattu , Vijayakumar Srinivasan 
Published: March 2020

AbstractPalliative concurrent chemoradiotherapy has not been well evaluated for patients who are not a candidate for definitive treatment. Even though stereotactic radiotherapy has established a role in the re‐irradiation of recurrent head and neck tumors, its role is not established as a possible primary treatment modality for patients who are not eligible for curative treatment. This article reviews the available literature on the role of chemoradiotherapy and stereotactic radiation for palliation of previously untreated head and neck cancers.
Docetaxel‐resistant prostate cancer cells become sensitive to gemcitabine due to the upregulation of ABCB1
Authors: Seo Ho Kyung , Lee Sang‐Jin , Kwon Whi‐An , Jeong Kyung‐Chae 
Published: March 2020

AbstractBackgroundDocetaxel is the preferred chemotherapeutic agent for hormone‐refractory prostate cancer (PC) patients. However, patients eventually develop docetaxel resistance, and no effective treatment options are available for them.ObjectiveWe aimed to establish docetaxel resistance in castration‐resistant prostate cancer (CRPC) cell lines (DU145/TXR, PC‐3/TXR, and CWR22/TXR) and characterized transcriptional changes upon acquiring resistance to the docetaxel.MethodsHuman PC cells (DU145, PC‐3, CWR22) and all docetaxel‐resistant cells were maintained in Roswell Park Memorial Institute Medium (RPMI) 1640 media supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin. ABCB1 was detected by using both parental and docetaxel‐resistant CRPCs prepared for flow cytometry. For the evaluation of tumor‐suppressive effects under each chemotherapeutic agent, subcutaneous xenografts of DU145 or DU145/TXR were implanted at the mouse flank.ResultsThe P‐glycoprotein‐encoding gene ABCB1 was distinctively upregulated in the resistant cells, and its overexpression played an essential role in docetaxel resistance in CRPC. When tested for the cytotoxicity of gemcitabine, another option for chemotherapy, the docetaxel‐resistant cells were shown to become sensitive to the drug, implying additional phenotypic transformation in the docetaxel‐resistant cells. Studies using xenograft animal models demonstrated that the growth of tumors composed of both docetaxel‐sensitive and docetaxel‐resistant cells was deterred most profoundly when docetaxel and gemcitabine were administered together.ConclusionThis study suggests that when a drug develops therapeutic resistance, sensitivity tests could be another option, ultimately providing insight into a novel alternative clinical strategy.
On the Problem of Multiple Minima on the S2 Excited Potential Energy Surface of Benzene: A Restricted Active Space Self Consistent Field Study
Authors: Varras Panayiotis C. , Gritzapis Panagiotis S. , Siskos Michael G. 
Published: March 2020

AbstractApplication of the Restricted Active Space Self‐Consistent Field Theory on the S2 excited state potential energy surface of benzene shows the existence of three minima. Of these, the first one is planar with a D6h molecular point group, while the other two have a boat type structure with an approximate C2v symmetry. All three minima have a biradicaloid structure and constitute potential candidates for new photochemical pathways on the S2 surface. A common S2/S1 Conical Intersection, which is accessible from all three S2 minima has been found which decays to the S1 potential energy surface (PES) giving benzene S1 minimum as the only photoproduct.
Efficient Synthesis, Antibacterial, Antifungal, Antioxidant and Cytotoxicity Study of 2‐(2‐Hydrazineyl)thiazole Derivatives
Authors: Adole Vishnu A. , More Rahul A. , Jagdale Bapu S. , Pawar Thansing B. , Chobe Santosh S. 
Published: March 2020

AbstractIn the present investigation, an alluring green PEG‐400 mediated one‐pot synthesis of novel 2‐(2‐hydrazinyl)thiazole derivatives from 1,2,6,7‐tetrahydro‐8H‐indeno[5,4‐b]furan‐8‐one has been unveiled via a novel synthetic pathway. The application of PEG in organic reactions as a reaction media is one of the fantastic tools of green chemistry as reactions can be carried out under generous conditions limiting environmental peril and chemical waste. PEG‐400 is recognized as a low‐cost, non‐flammable, environmentally benign, recyclable, and richly available green solvent. A series of novel 2‐(2‐hydrazineyl)thiazole derivatives have been synthesized in good to excellent yield by using the green capability of PEG‐400 solvent. These newly synthesized compounds were tested for their antimicrobial and antioxidant activities. The results revealed that these compounds show good activities compared with the standard. Additionally, all the synthesized compounds exhibit negligible cytotoxicity as compared to the positive control. The structures of all novel compounds reported herein are established using FT‐IR, 1H NMR, 13C NMR, D2O exchange experiment and HRMS techniques.
Influence of Anion on Physical and Electronic Property of Imidazolium Ionic Liquids: Role of Weak Interactions
Authors: Panja Sumit K. 
Published: March 2020

AbstractIn present work, role of weak interactions on physical property of newly synthesized 2,4‐Dinitrophenolate (DNP) anion‐based imidazolium room temperature ionic liquids (RTILs) has been investigated for understanding effect of small structural change in anion. Aromatic and aliphatic H‐bonding interaction do not play significant role on physical properties of these RTILs. But weak π‐π stacking interaction plays an important role to determine the physical properties of these RTILs. The DNP anion shows unique characteristic intramolecular charge transfer (ICT) process due to presence of its quinoid structure in solution. Quinoid structure of DNP anion in these RTILs does not allow to form strong intermolecular ion‐pair cluster through π‐π stacking interaction. As intermolecular interactions are very less, DNP based RTILs are liquids at room temperature. Tuning electronic and physical properties of these yellow coloured DNP based RTILs are raised only from DNP anion.
Synthesis of New Aza‐ and Thia‐Crown Ether Based Amino Acids
Authors: Schneider Tobias , Brüssow Nico , Yuvanc Alev , Budisa Nediljko 
Published: March 2020

AbstractCrown ethers have been known since the middle of the 20th century as metal chelating agents with numerous applications. For example, amino acids functionalized with crown ethers have been used to create artificial ion channels. However, only a few of those crown amino acids are known, all of which contain exclusively oxygen as heteroatoms in the crown ether moiety. Alternative structures may be desirable to explore new biological or pharmaceutical applications. Hence, we aim to expand the scope of available crown ether amino acids ‐ in particular those with heteroatoms other than oxygen. Herein we describe the synthesis of three previously unknown amino acids bearing a crown ether moiety. We use two distinct synthetic routes to avoid the use of hazardous reagents. Two of these three amino acids bear sulfur atoms in the crown ether, while the third contains a nitrogen atom.
Diurnal variation of salivary cortisol in captive African elephants (Loxodonta africana) under routine management conditions and in relation to a translocation event
Authors: Hambrecht Susan , Oerke Ann‐Kathrin , Heistermann Michael , Dierkes Paul Wilhelm 
Published: March 2020

AbstractThe present study assessed the diurnal variation in salivary cortisol in captive African elephants during routine management (baseline) and in relation to a potential stressor (translocation) to evaluate to what extent acute stress may affect diurnal cortisol patterns. Under baseline conditions, we collected morning and afternoon saliva samples of 10 animals (three zoos) on different days in two study periods (n = 3–10 per animal, daytime and period). Under stress conditions, we sampled the transported cow (newcomer) and the two cows of the destination zoo before and after the transport in the morning and afternoon (n = 3–9 per animal, daytime and transport phase), as well as after the first introduction of the newcomer to the bull (n = 1 per animal). Cortisol was measured in unextracted samples by enzyme immunoassay. Under baseline conditions, we observed the expected diurnal variation with higher cortisol levels in the morning than in the afternoon. Under stress conditions, neither a significant difference between pre‐ and posttransport, nor between morning and afternoon levels was found. The percentage difference between morning and afternoon cortisol after the transport, however, was remarkably lower than before the transport in the newcomer potentially indicating a stress response to familiarization. Saliva samples taken immediately after the introduction of the newcomer to the bull revealed a marked cortisol increase. Our findings indicate that stressors may disturb the diurnal cortisol rhythm. Furthermore, provided that samples can be collected promptly, salivary cortisol is a useful minimally invasive measure of physiological stress in the African elephant.
NLO massive event-shape differential and cumulative distributions
Authors: Lepenik Christopher , Mateu Vicent 
Published: March 2020

Abstract
We provide a general method to effectively compute differential and cumulative event-shape distributions to O(αs) precision for massive quarks produced primarily at an e+e− collider. In particular, we show that at this order, due to the screening of collinear singularities by the quark mass, for all event shapes linearly sensitive to soft dynamics, there appear only two distributions at threshold: a Dirac delta function and a plus distribution. Furthermore, we show that the coefficient of the latter is universal for any infra-red and collinear safe event shape, and provide an analytic expression for it. Likewise, we compute a general formula for the coefficient of the Dirac delta function, which depends only on the event-shape measurement function in the soft limit. Finally, we present an efficient algorithm to compute the differential and cumulative distributions, which does not rely on Monte Carlo methods, therefore achieving a priory arbitrary precision even in the extreme dijet region. We implement this algorithm in a numeric code and show that it agrees with analytic results on the distribution for 2-jettiness, heavy jet mass and a massive generalization of C-parameter.
Erratum to: Hearing preservation in children with electric-acoustic stimulation after cochlear implantation
Authors: Rader T. , Bohnert A. , Matthias C. , Koutsimpelas D. , Kainz M-A. , Strieth S. 
Published: March 2020

The article Hearing preservation in children with electric-acoustic stimulation after cochlear implantation—Outcome after electrode insertion with minimal insertion trauma, written by T. Rader, A. Bohnert, C. Matthias, D. Koutsimpelas, M‑A. Kainz, S. Strieth was originally published electronically
Accidental perforations during root canal treatment: an 8-year nationwide perspective on healthcare malpractice claims
Authors: Vehkalahti Miira M. , Swanljung Outi 
Published: March 2020

Abstract
Objectives
To assess occurrence and its variation over time of serious accidental perforations during endodontic treatment and the fate of perforated teeth by tooth type and characteristics of patients and dentists.

Materials and methods
Data, based on patient documents on healthcare malpractice claims, comprised all endodontic injuries (n = 970) verified by the Patient Insurance Centre in Finland in 2002–2006 and 2011–2013. Two specialists in endodontics scrutinized the documents. Accidental perforations were recorded by location (tooth type, chamber/canals) and dichotomized as avoidable (could have been avoided by following good clinical practice) or unavoidable (normal treatment-related risks). Fate of perforation cases was recorded as treatment discontinued, root canal(s) filled, or tooth extracted. Background information included patients’ and dentists’ sex and age and the service sector. Statistical evaluation used Chi-square tests.

Results
Serious accidental perforations comprised 29% of all verified injuries. Most perforations were judged as avoidable: 93% in patients aged below 35 years, 87% when located in the pulp chamber or in molars (84%); 70% of all perforations and 75% of those in molars resulted in tooth extraction. The overall rate of serious accidental perforations was 17.6 cases per 100,000 endodontic patients per year.

Conclusions
The rate of serious accidental perforations increased over time. The majority was in molars and resulted in tooth extraction.

Clinical relevance
Accidental perforations comprise almost a third of serious injuries during root canal treatment. However, four of five perforations could be avoided by following good clinical practice. Therefore, training is needed before adopting new working equipment and methods.
Analyse von Tilgerkonfigurationen mit trockenen Reibungselementen
Authors: Aramendiz Jimmy , Fidlin Alexander 
Published: March 2020

Zusammenfassung Die Ergreifung von Maßnahmen zur Schwingungsreduktion ist eine im Maschinenbau wichtige Aufgabe, da unerwünschte Vibrationen zu Systemstörungen führen können. Insbesondere bei Leichtbausystemen wird die natürlich vorhandene interne Dämpfung des Systems reduziert und neue, innovative, energieeffiziente Dämpfungsalternativen sind erforderlich. Die vorliegende Arbeit beschäftigt sich mit zwei Systemen: der trockene Lock-Up Dämpfer und der vorgespannte trockene Reibungstilger. Diese Systeme basieren auf trockener Reibung und nutzen die Haft-Gleit-Eigenschaften aus, um Schwingungen im System zu reduzieren. Die Bewegungsgleichung dieser Systeme, sowie numerische Parameterstudien und analytische Lösungen via Mittelwertbildungsverfahren werden vorgestellt. Anschließend werden die Dämpfungsmechanismen in transienten Simulationen verglichen.
Extent of neck dissection for patients with clinical N1 oral cancer
Authors: Kakei Yasumasa , Komatsu Hirokazu , Minamikawa Tsutomu , Hasegawa Takumi , Teshima Masanori , Shinomiya Hirotaka , Otsuki Naoki , Nibu Ken-ichi , Akashi Masaya 
Published: March 2020

Abstract
Background
No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis.

Patients
Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I–V neck dissection as the initial treatment.

Results
None of the 100 patients had pathological lymph-node metastasis (pLN) to level V. pLN to level IV was observed in two patients with tongue cancer in whom clinical lymph-node metastasis was preoperatively observed at level II.

Conclusions
Level V may be excluded in the neck dissection for patients with N1 oral cancers. Level IV dissection should be considered in the patient with tongue cancer and clinical lymph-node metastasis at level II.