bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-TUBE: dielectric waveguide cable for high-speed communication
Authors: Song Ha Il , Lee Joon-Yeong , Won Hyosup , Kim Chang-Ahn , Jin Huxian , Eu Jake , Park Jinho , Bae Hyeon-Min 
Published: October 2020

AbstractThe demand for advanced interconnects to satisfy market requirements on bandwidth, cost, and power is ever increasing with the expansion of data centers. An interconnect called E-TUBE is presented as a cost-and-power-efficient all-electrical-domain wideband waveguide solution for high-speed high-volume short-reach communication links. The E-TUBE achieves an unprecedented level of throughput-distance product, bending radius, and channel density without requiring complex manufacturing process. The E-TUBE link demonstrates nearly 25 GHz bandwidth at a carrier frequency of 70 GHz and exhibits a frequency-independent insertion loss of 5 dB/m with a frequency-independent group delay of 4 ns/m. Such loss and delay characteristics independent of frequency enabled broadband data transmission over extended reach compared to conventional waveguide links. The E-TUBE link transmits 25 Gbps NRZ data over 3 m distance using a 70 GHz RF CMOS transceiver IC, which is the state-of-the-art throughput-reach product. This new interconnect is expected to overcome the limitations of existing electrical and optical interconnects and to replace them in high throughput links, including but not limited to, 100/400 Gbps board-to-board communications.
Spatio-temporal distribution and acoustic characterization of haddock (Melanogrammus aeglefinus, Gadidae) calls in the Arctic fjord Kongsfjorden (Svalbard Islands)
Authors: Buscaino G. , Picciulin M. , Canale D. E. , Papale E. , Ceraulo M. , Grammauta R. , Mazzola S. 
Published: October 2020

AbstractIn this study we analysed the acoustic properties and presence of haddock calls in the Arctic fjord Kongsfjorden (79° N–12° E, Svalbard Islands, Norway) in one year. Data were collected with three autonomous acoustic recorders located in the inner, middle, and outer parts of the fjord. The fjord is characterized by a gradient of oceanographic conditions from the inner to the outer part, reflecting changes from Arctic to Atlantic waters. Haddock sounds were more abundant in the outer fjord than in the middle fjord, whereas they were absent at the inner site. Mainly at the open-water site, the call abundance exhibited strong periodicity and a correlation with the cycles of neap tide (15 days) in August, with a clear diel cycle (24 h) in September and October. This result suggests that in this extreme environment with 24 h of light during summer, haddock regulate their acoustic activity according to the main available oscillating external physical driver, such as tide during the polar summer, while when the alternation of light/dark starts, they shift the periodicity of their calls to a diel cycle. Calls were recorded outside the spawning period (from July to October), and their characteristics indicated non-reproductive communicative contests. By using a detailed sound analysis based on previous laboratory studies for the first time, we suggest that the monitored population contains mainly juveniles (44% compared to 41% females and only approximately 15% mature males), showing the predominance of females in the middle fjord and juveniles at the open-water site.
Cerebrospinal fluid neopterin as a biomarker of neuroinflammatory diseases
Authors: Molero-Luis Marta , Casas-Alba Didac , Orellana Gabriela , Ormazabal Aida , Sierra Cristina , Oliva Clara , Valls Anna , Velasco Jesus , Launes Cristian , Cuadras Daniel , Pérez-Dueñas Belén , Jordan Iolanda , Cambra Francisco J. , Ortigoza-Escobar Juan D. , Muñoz-Almagro Carmen , Garcia-Cazorla Angels , Armangué Thais , Artuch Rafael 
Published: October 2020

AbstractThe elevation of neopterin in cerebrospinal fluid (CSF) has been reported in several neuroinflammatory disorders. However, it is not expected that neopterin alone can discriminate among different neuroinflammatory etiologies. We conducted an observational retrospective and case–control study to analyze the CSF biomarkers neopterin, total proteins, and leukocytes in a large cohort of pediatric patients with neuroinflammatory disorders. CSF samples from 277 subjects were included and classified into four groups: Viral meningoencephalitis, bacterial meningitis, acquired immune-mediated disorders, and patients with no-immune diseases (control group). CSF neopterin was analyzed with high-performance liquid chromatography. Microbiological diagnosis included bacterial CSF cultures and several specific real-time polymerase chain reactions. Molecular testing for multiple respiratory pathogens was also included. Antibodies against neuronal and glial proteins were tested. Canonical discriminant analysis of the three biomarkers was conducted to establish the best discriminant functions for the classification of the different clinical groups. Model validation was done by biomarker analyses in a new cohort of 95 pediatric patients. CSF neopterin displayed the highest values in the viral and bacterial infection groups. By applying canonical discriminant analysis, it was possible to classify the patients into the different groups. Validation analyses displayed good results for neuropediatric patients with no-immune diseases and for viral meningitis patients, followed by the other groups. This study provides initial evidence of a more efficient approach to promote the timely classification of patients with viral and bacterial infections and acquired autoimmune disorders. Through canonical equations, we have validated a new tool that aids in the early and differential diagnosis of these neuroinflammatory conditions.
Affinity enrichment of extracellular vesicles from plasma reveals mRNA changes associated with acute ischemic stroke
Authors: Wijerathne Harshani , Witek Malgorzata A. , Jackson Joshua M. , Brown Virginia , Hupert Mateusz L. , Herrera Kristina , Kramer Cameron , Davidow Abigail E. , Li Yan , Baird Alison E. , Murphy Michael C. , Soper Steven A. 
Published: October 2020

AbstractCurrently there is no in vitro diagnostic test for acute ischemic stroke (AIS), yet rapid diagnosis is crucial for effective thrombolytic treatment. We previously demonstrated the utility of CD8(+) T-cells’ mRNA expression for AIS detection; however extracellular vesicles (EVs) were not evaluated as a source of mRNA for AIS testing. We now report a microfluidic device for the rapid and efficient affinity-enrichment of CD8(+) EVs and subsequent EV’s mRNA analysis using droplet digital PCR (ddPCR). The microfluidic device contains a dense array of micropillars modified with anti-CD8α monoclonal antibodies that enriched 158 ± 10 nm sized EVs at 4.3 ± 2.1 × 109 particles/100 µL of plasma. Analysis of mRNA from CD8(+) EVs and their parental T-cells revealed correlation in the expression for AIS-specific genes in both cell lines and healthy donors. In a blinded study, 80% test positivity for AIS patients and controls was revealed with a total analysis time of 3.7 h.
LncRNA HOTAIR modulates hepatitis B virus transcription and replication by enhancing SP1 transcription factor
Authors: Ren Fang , Ren Ji-Hua , Song Chun-Li , Tan Ming , Yu Hai-Bo , Zhou Yu-Jiao , Qin Yi-Ping , Cheng Sheng-Tao , Zhang Yuan , Huang Ai-Long , Chen Juan , Yang Xiao 
Published: October 2020

Abstract
Hepatitis B virus (HBV) infection remains a global public health problem. Nearly 257 million people worldwide have been infected with HBV, resulting in 887,000 people dying of cirrhosis or liver cancer caused by chronic hepatitis B (CHB) annually. Therefore, identification of new targets against HBV is urgently needed. Long noncoding RNAs (LncRNAs) have gained widespread attention in recent years due to their function in cancer, inflammation and other diseases. Notably, a growing number of lncRNAs have been found to play a role in HBV development. In the present study, we first identified a famous lncRNA, HOTAIR, which was significantly up-regulated in HBV-infected cells and PBMCs from CHB patients. Furthermore, we evaluated the clinical relevance of HOTAIR in 20 CHB patients and found that higher levels of HOTAIR expression were associated with higher ALT/AST levels and were positively correlated with HBsAg and HBV DNA levels. In addition, functional analysis showed that HOTAIR promoted HBV transcription and replication by elevating the activities of HBV promoters via modulation of the levels of cccDNA-bound SP1. In conclusion, our study reveals that HOTAIR expression is correlated with the clinicopathological and physiological characteristics of HBV. Thus, HOTAIR may serve as a novel HBV diagnostic and therapeutic biomarker based on its ability to facilitate HBV transcription and replication.
Quantitative Videofluoroscopic Analysis of Swallowing Physiology and Function in Individuals With Chronic Obstructive Pulmonary Disease
Authors: Mancopes Renata , Peladeau-Pigeon Melanie , Barrett Emily , Guran Andrea , Smaoui Sana , Pasqualoto Adriane Schmidt , Steele Catriona M. 
Published: October 2020

Purpose
Dysphagia is a serious extra pulmonary manifestation of chronic obstructive pulmonary disease (COPD). However, the nature of abnormalities in swallowing physiology in COPD has yet to be clearly established. We explored the frequency of swallowing measures outside the healthy reference range in adults with COPD.

Method

Participants were 28 adults aged 41–79 years (18 men, 20 women) with stable COPD. Disease severity was classified as GOLD (Global Initiative For Chronic Obstructive Lung Disease) Stages 1 (4%), 2 (25%), 3 (53%), and 4 (18%). Participants underwent a videofluoroscopy and swallowed 20% w/v thin barium in, followed by 20% w/v mildly, moderately, and extremely thick barium prepared with a xanthan gum thickener. Blinded duplicate ratings of swallowing safety, efficiency, kinematics, and timing were performed according to the ASPEKT method (Analysis of Swallowing Physiology: Events, Kinematics and Timing). Comparison data for healthy adults aged < 60 years were extracted from an existing data set. Chi-square and Fisher's exact tests compared the frequencies of measures falling < 1
SD
/ > 1
SD
from mean reference values (or < the first or > the third quartile for skewed parameters).

Results

Participants with COPD did not display greater frequencies of penetration–aspiration, but they were significantly more likely (
p
< .05) to display incomplete laryngeal vestibule closure (LVC), longer time-to-LVC, and shorter LVC duration. They also displayed significantly higher frequencies of short upper esophageal sphincter opening, reduced pharyngeal constriction, and pharyngeal residue.

Conclusion
This analysis reveals differences in swallowing physiology in patients with stable COPD characterized by impaired safety related to the mechanism, timing, and duration of LVC and by impaired swallowing efficiency with increased pharyngeal residue related to poor pharyngeal constriction.
Evolution of spheroidal dust in electrically active sub-stellar atmospheres
Authors: Stark C. R. , Diver D. A. 
Published: October 2020

Context. Understanding the source of sub-stellar polarimetric observations in the optical and near-infrared is key to characterizing sub-stellar objects and developing potential diagnostics for determining properties of their atmospheres. Differential scattering from a population of aligned, non-spherical dust grains is a potential source of polarization that could be used to determine geometric properties of the dust clouds.
Aims. This paper addresses the problem of the spheroidal growth of dust grains in electrically activated sub-stellar atmospheres. It presents the novel application of a mechanism whereby non-spherical, elongated dust grains can be grown via plasma deposition as a consequence of the surface electric field effects of charged dust grains.
Methods. We numerically solve the differential equations governing the spheroidal growth of charged dust grains via plasma deposition as a result of surface electric field effects in order to determine how the dust eccentricity and the dust particle eccentricity distribution function evolve with time. From these results, we determine the effect of spheroidal dust on the observed linear polarization.
Results. Numerical solutions show that e ≈ 0.94 defines a watershed eccentricity, where the eccentricity of grains with an initial eccentricity less than (greater than) this value decreases (increases) and spherical (spheroidal) growth occurs. This produces a characteristic bimodal eccentricity distribution function yielding a fractional change in the observed linear polarization of up to ≈0.1 corresponding to dust grains of maximal eccentricity at wavelengths of ≈1 μm, consistent with the near infrared observational window. Order of magnitude calculations indicate that a population of aligned, spheroidal dust grains can produce degrees of polarization P ≈ 𝒪(10−2 − 1%) consistent with observed polarization signatures.
Conclusions. The results presented here are relevant to the growth of non-spherical, irregularly shaped dust grains of general geometry where non-uniform surface electric field effects of charged dust grains are significant. The model described in this paper may also be applicable to polarization from galactic dust and dust growth in magnetically confined plasmas.
The molecular mass function of the local Universe
Authors: Andreani P. , Miyamoto Y. , Kaneko H. , Boselli A. , Tatematsu K. , Sorai K. , Vio R. 
Published: October 2020

Aims.We construct the molecular mass function using the bivariateK-band-mass function (BMF) of theHerschelReference Survey (HRS), which is a volume-limited sample that has already been widely studied at the entire electromagnetic spectrum.Methods.The molecular mass function was derived from theK-band and the gas mass cumulative distribution using a copula method, which is described in detail in our previous papers.Results.The H2mass is relatively strongly correlated with theK-band luminosity because of the tight relation between the stellar mass and the molecular gas mass within the sample with a scatter, which is likely due to those galaxies which have lost their molecular content because of environmental effects or because of a larger gas consumption due to past star formation processes. The derived H2MF samples the molecular mass range from ∼4 × 106M⊙to ∼1010 M⊙, and when compared with theoretical models, it agrees well with the theoretical predictions at the lower end of the mass values; whereas at masses larger than 1010 M⊙, the HRS sample may miss galaxies with a large content of molecular hydrogen and the outcomes are not conclusive. The value of the local density of the molecular gas mass inferred from our analysis is ∼1.5 × 107 M⊙Mpc−3, and it is compared with the results at larger redshifts, confirming the lack of strong evolution for the molecular mass density betweenz= 0 andz= 4.Conclusions.This is the first molecular mass function that has been derived on a complete sample in the local Universe, which can be used as a reliable calibration at redshiftz= 0 for models aiming to predict the evolution of the molecular mass density.
SP_Ace v1.4 and the new GCOG library for deriving stellar parameters and elemental abundances
Authors: Boeche C. , Vallenari A. , Lucatello S. 
Published: October 2020

Context. Ongoing and future massive spectroscopic surveys will collect very large numbers (106–107) of stellar spectra that need to be analyzed. Highly automated software is needed to derive stellar parameters and chemical abundances from these spectra.
Aims. We present the new version of SP_Ace (Stellar Parameters And Chemical abundances Estimator) a code that derives stellar parameters and elemental abundance from stellar spectra. The new version covers a larger spectral resolution interval (R = 2000−40 000) and its new library covers bluer wavelengths (4800–6860 Å).
Methods. SP_Ace relies on the General-Curve-Of-Growth (GCOG) library based on 6700 absorption lines whose oscillator strengths were calibrated astrophysically. We developed the calibration method and applied it to all the lines. From the new line list obtained we build the GCOG library, adopting an improved method to correct for the opacity of the neighboring lines. We implemented a new line profile for the code SP_Ace that better reproduces that of synthetic spectra. This new version of SP_Ace and the GCOG library has been tested on synthetic and real spectra to establish the accuracy and precision of the derived stellar parameters.
Results. SP_Ace can derive the stellar parameters Teff, log g, [M/H], and chemical abundances with satisfactory results; the accuracy depends on the spectral features that determine the quality, such as spectral resolution, signal-to-noise ratio, and wavelength coverage. Systematic errors were identified and quantified where possible. The source code is publicly available.
Satellite observation of the dust trail of a major bolide event over the Bering Sea on December 18, 2018
Authors: Borovička J. , Setvák M. , Roesli H. , Kerkmann J. K. 
Published: October 2020

Context.One of the most energetic bolide events in recent decades was detected by the US Government sensors (USGS) over remote areas of the Bering Sea on December 18, 2018, 23:48 UT. No ground-based optical observations exist.Aims.Using the satellite imagery of the dust trail left behind by the bolide, we tried to reconstruct the bolide trajectory. In combination with the bolide speed reported by the USGS, we computed the pre-atmospheric orbit. Observations in various spectral bands from 0.4 to 13.3μm enabled us to study the dust properties.Methods.Images of the dust trail and its shadow obtained from various angles by the Multi-angle Imaging SpectroRadiometer (MISR) on board the Terra polar satellite and geostationary satellites Himawari-8 and Geostationary Operational Environmental Satellite 17 (GOES-17) were used. The initial position and orientation of the trail was varied, and its projections into the geoid coordinate grid were computed and compared with real data. Trail motion due to atmospheric wind was taken into account. Radiances and reflectances of selected parts of the dust trail were taken from the Moderate-resolution Imaging Spectroradiometer (MODIS) on board Terra. Reflectance spectra were compared with asteroid spectra.Results.The bolide radiant was found to be 13° ± 9° from that reported by the USGS, at azimuth 130° (from south to west) and zenith distance 14°. The bolide position was confirmed, including the height of maximum dust deposition around 25 km. The incoming asteroid had to be quite strong to maintain a high speed down to this height. The speed of 32 km s−1, reported by the USGS, was found to be plausible. The orbit had a high inclination of about 50° and a perihelion distance between 0.95–1 AU. The semimajor axis could not be restricted well but was most probably between 1–3 AU. The dust reflectance was much lower in the blue than in the red, consistent with the material of A- or L-type asteroid. The absorption at 11μm confirms the presence of crystalline silicates in the dust.
Drop Foot Secondary to a Peroneal Intraneural Ganglion Connected to the Superior Tibiofibular Joint: A Case Report
Authors: Kıbıcı Kenan , Erok Berrin , Onat Akın 
Published: October 2020

AbstractPeroneal neuropathy is the most frequent mononeuropathy of the lower extremity. Intraneural ganglion cysts (INGCs) are among rare causes of peroneal nerve palsy. According to the articular (synovial) theory, the articular branch plays the key role in the pathogenesis. Patients present with pain around the fibular head and neck, motor weakness resulting in foot drop and paresthesia in the anterolateral calf and foot. Ultrasonography (US) and MRI are both useful in the diagnosis, but MRI is the best imaging modality in the demonstration of the articular connection and the relation of the cyst with adjacent structures, even without special neurography sequences. We present a 32-year-old male patient referred to our neurosurgery clinic with suspicion of lumbar radiculopathy. He presented with right foot drop which began 3 weeks prior. On examination, there was 90% loss in the ankle dorsiflexion and finger extension. Ankle eversion was also weakened. There was no low back or posterolateral thigh pain to suggest L5 radiculopathy and sciatic neuropathy. Following negative lumbar spine MRI, peripheral neuropathy was concerned. Electrodiagnostic evaluations findings were consistent with acute/subacute common peroneal nerve (CPN) axonal neuropathy. Subsequent MRI of knee showed a homogeneous, thin-walled tubular cystic lesion, extending along the course of the CPN and its articular branch. Full recovery of the neuropathy was achieved with early diagnosis and decompression via microsurgical epineurotomy. The diagnosis of INGC was confirmed by histopathologic examination. INGCs, although rare, should also be considered in the differential diagnosis of peripheral mononeuropathies.
Pseudoobstrucción colónica aguda (Sindrome de Ogilvie) posterior a una nefrectomía radical: Reporte de caso
Authors: Gentili Georgina , Colella María Florencia , Deluca Agustín , Pérez Pablo Leonardo , Rossi Pablo Cesar , Damia Omar Pablo Alejandro , Laplumé Ezequiel Elizalde , Sarno Patricio Lucio 
Published: October 2020

ResumenEl Sindrome de Ogilvie se caracteriza por una dilatación masiva del colon y una clínica sugestiva de obstrucción intestinal mecánica, sin causa orgánica. Presentamos un caso de dilatación aguda idiopática del colon secundaria a una cirugía abdominal.El objetivo de este reporte fue la descripción de una patología urológica inusual que puede pasarse por alto o tratarse como un íleo adinámico y, la revisión de la literatura relacionada con la definición, factores de riesgos, etiología, fisiopatología y el tratamiento de la misma.Paciente masculino de 61 años con antecedente de nefrectomía radical izquierda por tumor renal que, a las 48hs del alta hospitalaria, consultó por presentar distensión abdominal aguda. Se solicitó una radiografía abdominal y una tomografía computada que evidenciaba importante dilatación intestinal y un diámetro cecal mayor a 12cm.Se practicó una laparotomía exploradora de urgencia constatándose dilatación colónica del colon transverso y ascendente con un cambio de diámetro a nivel del ángulo esplénico, sin causa osbtructiva. Finalmente, se realizó colostomía en asa.A los 6 meses de seguimiento, la videocolonoscopía no mostró lesiones endoluminales concluyendo en un Sindrome de Ogilvie secundario a la nefrectomía. Finalmente, se efectuó reconstrucción del tránsito con buena evolución posterior.En nuestro caso, el Sindrome de Ogilvie fue una complicación postoperatoria y como fallaron las terapias conservadoras iniciales instauradas, este reporte provee una modalidad de tratamiento alternativo. Si se reconoce temprano y se trata adecuadamente, la pseudoobstrucción se resolverá en la mayoría de los pacientes y la tasa de mortalidad posterior será menor.