bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Patient-Centered Asthma Management Communication Intervention for Rural Latino Children: Protocol for a Waiting-List Randomized Controlled Trial
Authors: Dawson Robin M , Heiney Sue P , Messias DeAnne Hilfinger , Ownby Dennis 
Published: September 2020

Background
Rural Latino children with asthma suffer high rates of uncontrolled asthma symptoms, emergency department visits, and repeat hospitalizations. This vulnerable population must negotiate micro- and macrolevel challenges that impact asthma management, including language barriers, primary care access, parental time off from work, insurance coverage, distance from specialty sites, and documentation status. There are few proven interventions that address asthma management embedded within this unique context.

Objective
Using a bio-ecological approach, we will determine the feasibility of a patient-centered collaborative program between rural Latino children with asthma and their families, school-based nursing programs, and primary care providers, facilitated by the use of a smartphone-based mobile app with a Spanish-language interface. We hypothesize that improving communication through a collaborative, patient-centered intervention will improve asthma management, empower the patient and family, decrease outcome disparities, and decrease direct and indirect costs.

Methods
The specific aims of this study include the following: (1) Aim 1: produce and validate a Spanish translation of an existing asthma management app and evaluate its usability with Latino parents of children with asthma, (2) Aim 2: develop and evaluate a triadic, patient-centered asthma intervention preliminary protocol, facilitated by the bilingual mobile app validated in Aim 1, and (3) Aim 3: investigate the feasibility of the patient-centered asthma intervention from Aim 2 using a waiting-list randomized controlled trial (RCT) to investigate the effects of the intervention on school days missed and medication adherence.

Results
Mobile app translation, initial usability testing, and app software refinement were completed in 2019. Analysis is in progress. Preliminary protocol testing is underway; we anticipate that the waiting-list RCT, using the refined protocol developed in Aim 2, will commence in fall 2020.

Conclusions
Tailored, technology-based solutions have the potential to successfully address issues affecting asthma management, including communication barriers, accessibility issues, medication adherence, and suboptimal technological interventions.

Trial Registration
ClinicalTrials.gov NCT04633018; https://www.clinicaltrials.gov/ct2/show/NCT04633018

International Registered Report Identifier (IRRID)
DERR1-10.2196/18977
Threats of Bots and Other Bad Actors to Data Quality Following Research Participant Recruitment Through Social Media: Cross-Sectional Questionnaire
Authors: Pozzar Rachel , Hammer Marilyn J , Underhill-Blazey Meghan , Wright Alexi A , Tulsky James A , Hong Fangxin , Gundersen Daniel A , Berry Donna L 
Published: September 2020

Background
Recruitment of health research participants through social media is becoming more common. In the United States, 80% of adults use at least one social media platform. Social media platforms may allow researchers to reach potential participants efficiently. However, online research methods may be associated with unique threats to sample validity and data integrity. Limited research has described issues of data quality and authenticity associated with the recruitment of health research participants through social media, and sources of low-quality and fraudulent data in this context are poorly understood.

Objective
The goal of the research was to describe and explain threats to sample validity and data integrity following recruitment of health research participants through social media and summarize recommended strategies to mitigate these threats. Our experience designing and implementing a research study using social media recruitment and online data collection serves as a case study.

Methods
Using published strategies to preserve data integrity, we recruited participants to complete an online survey through the social media platforms Twitter and Facebook. Participants were to receive $15 upon survey completion. Prior to manually issuing remuneration, we reviewed completed surveys for indicators of fraudulent or low-quality data. Indicators attributable to respondent error were labeled suspicious, while those suggesting misrepresentation were labeled fraudulent. We planned to remove cases with 1 fraudulent indicator or at least 3 suspicious indicators.

Results
Within 7 hours of survey activation, we received 271 completed surveys. We classified 94.5% (256/271) of cases as fraudulent and 5.5% (15/271) as suspicious. In total, 86.7% (235/271) provided inconsistent responses to verifiable items and 16.2% (44/271) exhibited evidence of bot automation. Of the fraudulent cases, 53.9% (138/256) provided a duplicate or unusual response to one or more open-ended items and 52.0% (133/256) exhibited evidence of inattention.

Conclusions
Research findings from several disciplines suggest studies in which research participants are recruited through social media are susceptible to data quality issues. Opportunistic individuals who use virtual private servers to fraudulently complete research surveys for profit may contribute to low-quality data. Strategies to preserve data integrity following research participant recruitment through social media are limited. Development and testing of novel strategies to prevent and detect fraud is a research priority.
ANALISIS KELAYAKAN KOPERASI UNIT DESA DI DAERAH ISTIMEWA YOGYAKARTA
Authors: Siregar Abi Pratiwa , Jamhari Jamhari 
Published: September 2020

This research aims to (1) determine the financial performance of village unit cooperative/Koperausi Unit Desa (KUD) in Yogyakarta Special Region (2) determine the affecting factors of profit/selisih hasil usaha (SHU) (3) determine the institutional performance of village unit cooperative in Yogyakarta Special Region. The basic method used for this stufy is descriptive snalysis. The data used are the primary and secondary data. Data primary obtained through the interview whiledata secondary obtained through KUD’s annual report from 2011 untul 2012/ sampling method is purposive sampling, based on the highest profit value in each KUD in regency or city inYogyakarta Special region in 2012, any KUD in each regency or city taken 4 people respondents, 3 people of board organizer, and 1 inspector of each KUD. Method of analysis used financial rationanalysis to determine financial performance of village unit cooperation in Yogyakarta Special Region, multiple regression analysis to determine the affecting factors of profit and analysis efforts to determine tye institutional performance of village unit cooperative in Yogyakarta Special Region. The result showed that financial performance of village unit cooperative in Yogyakarta Special Region still low. The significant factors for affecting profit are business volume, dummy USP, dummy RMU, dummy electricity, and the number of members own capital, outside capital, total assets, dummy waserda, anda dummy saprotan are not significant factor for affecting profit. KUD in Yogyakarta Special Region having well-institution performance.
Falta de Competencia y Sobrecarga Laboral como Estresores en Prácticas Clínicas Intrahospitalarias
Authors: Morales-Herrera Edith , Amigo-Rojas Claudio , Bustamante-Ubilla Miguel 
Published: September 2020

Este trabajo estudia la falta de competencia y sobrecarga laboral como estresores en prácticas clínicas intrahospitalarias de enfermería. Se aplicó una metodología cuantitativa por medio del cuestionario bilingüe Kezkak, el cual considera nueve dimensiones de estrés. Se realizó un piloteo del instrumento con docentes para verificar entendimiento y comprensión del mismo. Los estudiantes fueron contactados vía on-line lográndose una cobertura de 89,6%. Se pudo concluir que los estudiantes de enfermería presentaron estrés durante las prácticas clínicas intrahospitalarias preferentemente al inicio. Dentro de los principales factores de estrés destacan la falta de competencia y sobrecarga de trabajo de los estudiantes de enfermería en sus periodos de prácticas clínicas en los servicios de Medicina y Cirugía.
How do security and benefits instill trustworthiness of a digital local currency?
Authors: Ključnikov Aleksandr , Civelek Mehmet , Polách Jiří , Mikoláš Zdeněk , Banot Michal 
Published: September 2020

Research background: The existence of new technologies and increase in the extensive usage of the internet by individuals, forces governments, local authorities and practitioners to create alternative payment methods such as digital currencies. However, some of the individuals are concerned about trusting these currencies since they negatively perceive their security. Moreover, some people with low income have the willingness to use these currencies in case of receiving some financial benefits. In this regard, security and benefits have been used as tools to increase the trustworthiness of digital currencies.
Purpose of the article: The goal of this study is to investigate and to examine the influences of security and benefits of a local digital currency on potential users? trust in this currency. This paper also considers the age and work experience of prospective users and investigate these variables? effects on stated relationships.
Methods: This paper is based on a case study that includes 413 respondents who are workers of a large company in Cieszyn Silesia region of the Czech Republic. A questionnaire survey was employed by researchers to determine the perceptions of potential local currency users. Binary logistic regression analyses were performed to examine the relationships between selected variables. Calculations were made using SPSS Statistics software.
Findings & Value added: The results of this paper confirm the positive influences of security and provided benefits on the trust of a digital currency. Regarding characteristics of potential users, perceptions of younger and less experienced users regarding the security and financial benefits are more positive to trust this currency comparing to older and more experienced respondents. Trade freedom of a country, long term orientation and individualistic characteristics of potential users might be reasons for the positive relation-ships between security, benefits and trust in a local digital currency. On the other hand, the income of prospective users, new technology curiosity, and experience of users might be mounting pieces of evidence to explain the differences in the perceptions of potential users regarding security, benefits and trust to a local digital currency. This paper also proposes some policy implementations to users, practitioners, local authorities and governments to make them cope with the security and trust issues of these currencies.
Progress and trends in pediatric hematopoietic cell transplantation in Central-East European countries
Authors: Czyżewski Krzysztof , Sedláček Petr , Štěrba Jaroslav , Bilic Ernest , Roganović Jelena , Krivan Gergely , Rascon Jelena , Colita Anca , Jazbec Janez , Švec Peter , Serhii Pavlyk , Lysytsia Oleksandr , Wachowiak Jacek , Styczyński Jan 
Published: September 2020

AbstractHematopoietic cell transplantation (HCT) is widely used as a treatment for acquired and congenital disorders. In recent years, a significant increase in transplant activity around the world has been observed, especially in Eastern European countries. This article aimed to assess progress and trends in pediatric HCT in Central-Eastern European countries between 2013 and 2018. Transplant activity survey in 2013 and 2018 in nine Central-Eastern European countries (Czech Republic, Croatia, Hungary, Lithuania, Poland, Romania, Slovakia, Slovenia, and Ukraine) was performed. The highest transplant rates in total were found in the Czech Republic and Hungary. When calculated per 10 million of the pediatric population, a 25.9% increase in the number of allo-HCT was observed with the highest in Croatia, Romania, Lithuania, and Poland; and a 12.2% increase in the number of auto-HCT was observed with the highest in Slovenia, Slovakia, Romania, Poland, Ukraine, and Croatia. We have shown, over the years 2013 and 2018, in some countries of Central-Eastern Europe that there was a significant increase in transplant activity, especially in those with the lower rates. This increase was observed mainly in centers already existing in 2013, especially in the allo-HCT setting. The rise of activity was significantly less influenced by the creation of new transplant centers or the increase in the number of pediatric transplant beds. In conclusion, our analysis indicates that in the Czech Republic, Hungary, Lithuania, and Slovenia, the actual infrastructure and the number of HCTs cover the needs, whereas in other countries, especially in Romania and Ukraine, the number of HCT needs to be increased.
Feasibility of up-front autologous stem cell transplantation for high risk diffuse large B-cell lymphoma – non-randomized analysis of 58 consecutive patients
Authors: Armatys Anna , Wieczorkiewicz-Kabut Agata , Kata Dariusz , Woźniczka Krzysztof , Kopińska Anna , Koclęga Anna , Spałek Adrianna , Helbig Grzegorz 
Published: September 2020

AbstractIntroductionHigh-dose chemotherapy supported by autologous stem cell transplantation (ASCT) continues to be a standard of care for relapsed diffuse large B-cell lymphoma (DLBCL) and may be considered as a frontline consolidation for a proportion of patients with high-risk features.AimWe evaluated the feasibility and safety of ASCT for high-risk DLBCL who are in first complete remission after standard treatment with chemotherapy ± rituximab.Material and methodsA retrospective analysis of 58 patients (36 males and 22 females) receiving up-front ASCT between 1996 and 2018 for remission consolidation.ResultsOf the diagnosed, fifty patients were in clinical stage ≥ III. Forty-two (72%) of transplanted patients had age-adjusted IPI ≥ 2. The “B” symptoms were present in 34 patients. The conditioning consisted of cyclophosphamide, carmustine, etoposide (CBV) in 32 patients, carmustine, cytarabine, etoposide, melphalan (BEAM) in 18, and 8 patients received bendamustine, cytarabine, etoposide, melphalan (BeEAM). The transplant-related mortality was 0% at day +30 and +100 after ASCT. Median overall survival (OS) was 4.2 years whereas progression-free survival (PFS) reached 3.0 years. The estimated 5-year OS and PFS were found to be 66% and 64%, respectively. The presence of “B” symptoms remained significance in multivariate analysis (HR 4.17 [95% CI: 1.19–14.5];p= 0.02). No grade 3 or 4 non-hematological adverse events were observed.ConclusionsUp-front ASCT was found to be a safe and feasible procedure with long-term remission in approximately 70% of patients.
An immunohistochemical study on the presence of nitric oxide synthase isoforms (nNOS, iNOS, eNOS) in the spinal cord and nodose ganglion of rats receiving ionising gamma radiation to their liver
Authors: Yılmaz Osman , Soygüder Zafer , Keleş Ömer Faruk , Yaman Turan , Yener Zabit , Uyar Ahmet , Çakır Tahir 
Published: September 2020

Abstract

Introduction
This study determined the presence of nitric oxide synthesis isoforms (nNOS, iNOS, and eNOS) in thoracic spinal cord segments and nodose ganglia of rats with gamma-irradiated livers.

Material and Methods
Male rats (n = 32) were divided into equal groups A, B, C, and D. In group A, the controls, no radiation was applied, while groups B, C, and D received 10 Gy of ionising gamma radiation. The rats of group B were euthanized at the end of the first day (d1), those of group C on the second day (d2), and those of group D on the third day (d3). The liver, spinal cord segments, and nodose ganglion tissues were dissected and fixed, and the liver sections were examined histopathologically. The other tissues were observed through a light microscope.

Results
Regeneration occurred at the end of d3 in hepatocytes which were radiation-damaged at the end of d1 and d2. On d1, some nNOS-positive staining was found in the neuronal cells of laminae I–III of the spinal cord and in neurons of the nodose ganglion, and on d3, some staining was observed in lamina X of the spinal cord, while none of note was in the nodose ganglion. Dense iNOS-positive staining was seen on d1 in the ependymal cells of the spinal cord and in the glial cells of the nodose ganglion, and on d3, there was still considerable iNOS staining in both tissues. There was clear eNOS-positive staining in the capillary endothelial cells of the spinal cord and light diffuse cytoplasmic staining in the neurons of the nodose ganglion on d1, and on d3, intense eNOS-positive staining was visible in several endothelial cells of the spinal cord, while light nuclear staining was recognised in the neurons of the nodose ganglion.

Conclusion
The nNOS, iNOS, and eNOS isoforms are activated in the spinal cord and nodose ganglion of rats after ionising radiation insult to the liver.
Colistin resistance of non-pathogenic strains of Escherichia coli occurring as natural intestinal flora in broiler chickens treated and not treated with colistin sulphate
Authors: Majewski Michał , Łukomska Anna , Wilczyński Jarosław , Wystalska Danuta , Racewicz Przemysław , Nowacka-Woszuk Joanna , Pszczola Marcin , Anusz Krzysztof 
Published: September 2020

Abstract

Introduction
A significant threat to public health is presented by antibiotic-resistant strains of bacteria, selective pressure on which results from antibiotic use. Colistin is an antibiotic commonly used in veterinary medicine, but also one of last resort in human medicine. Since the 2015 discovery in China of the mcr-1 gene encoding colistin resistance in Enterobacteriaceae, other countries have noted its presence. This study was to find the mcr-1 gene prevalence in E. coli isolated from poultry slaughtered in Poland.

Material and Methods
Cloacal swabs were taken from December 2017 to October 2018 from broiler chickens in three regions. The samples (n = 158) were grouped as flocks treated with colistin sulphate (n = 87) and those not treated (n = 71). Resistance to antimicrobials commonly used in poultry was evaluated by minimum inhibitory concentration. The presence of the mcr-1 gene was confirmed by PCR.

Results
Isolates containing the mcr-1 gene were yielded by 11.27% of the samples from not treated flocks and 19.54% of those from treated flocks, but no statistically significant difference in the prevalence of the gene was seen between the groups.

Conclusion
The results clearly preclude intensification of selective pressure for colistin resistance due to colistin sulphate treatment because they show that the avian gastrointestinal tract was already inhabited by colistin-resistant E. coli by the time the chickens came to the poultry house.
An effective intervention can contribute to enhancing social integration while reducing perceived stress in children
Authors: Carro Natalia , D'Adamo Paola , Lozada Mariana 
Published: September 2020

Introduction. This investigation evaluates whether an intervention involving mindfulness-based practices, socio-affective activities, and socio-cognitive instances can foster prosocial attitudes and positive social relationships, and reduce perceived stress in children. Method. The study was conducted with 44 children (20 girls and 24 boys) aged between 6 and 8 (M= 7.25 years, SD= 0.43), and followed a quasi experimental wait list design with two measurement time points (pre and post intervention). We analyzed relative changes in social integration, universal altruism and perceived stress levels. Results. Our results revealed that children who participated in the intervention showed an enhancement in social integration and universal altruism tests, and a decrease in the perceived stress indices. That is, children chose more peers as playmates and rejected fewer of them, while evidencing more prosocial attitudes. Discussion and Conclusion. Our findings suggest that this kind of intervention can contribute to fostering social integration and prosociality while promoting children’s health and wellbeing from an early age.
Understanding adolescents’ moral stance on examination malpractice through the lenses of parenting styles, test anxiety, and their academic self-efficacy
Authors: Nwosu Kingsley Chinaza , Nwasor Victor Chekume , Onyebuchi Geoffrey C. , Nwanguma Victor C 
Published: September 2020

Introduction. The increasing complex nature of academic dishonesty demands that empirical models are built to explain the psychosocial and motivational variables involved in the way examination malpractice is morally viewed by adolescents. This has been underexplored in Nigeria over the years given that available studies have not utilized designs that could give comprehensive understanding of pathways through which moral views of adolescents on examination malpractice could be predicted. Method. This study developed an empirical model using path analysis to explain the direct and indirect effects of parenting styles, test anxiety, academic self-efficacy on adolescents’ moral stance on examination malpractice scenarios. The multivariate predictor correlational research design was adopted. Dimensions of the parenting styles served as exogeneous variables while test anxiety, self-efficacy and moral stance on examination malpractice served as endogeneous variables with test anxiety and self-efficay serving as mediators. The sample size was made up of 741 senior seconday school students, classs one (SS1) from 15 secondary schools located in southeast geopolitical zone of Nigeria. Results. Findings showed, among others, that the final hypothesized model fit the data satisfactorily and that permissive parenting style and test anxiety significantly and positively predicted adolescents’ amoral stance on examination malpractice while authoritative parenting negatively predicted their amoral stance on examination malpractice. Permissive parenting style had both direct and indirect significant effects on adolescents’ moral stance on examination malpractice. Discussion and Conclusion. Discussion was based on the findings resulting to the conclusión that inappropriate parenting style and problematic psychological dispositions are factors that could influence the moral views of adolescents. For appropriate intervention to be mounted for students, there is the need to incorporate how adolescents are trained by their parents.
Can Oppositely Charged Polyelectrolyte Stars Form a Gel? A Simulational Study
Authors: Tagliabue Andrea , Landsgesell Jonas , Mella Massimo , Holm Christian 
Published: September 2020

We present a Langevin molecular dynamics study of an equimolar mixture ofmonodispersed oppositely charged di-block four-armed polyelectrolyte stars. We usean implicit solvent coarse-grained representation of the polyelectrolyte stars and variedthe length of the terminal charged blocks that reside on each arm. By varying thepolymer concentration we computed P-V diagrams and determined the free-swellingequilibrium concentration with respect to a pure water reservoir as a function of thecharged block length. We investigate various structural properties of the resultingequilibrium structures, like the number of ionic bonds, dangling arms, isolated stars,and cluster sizes. The ionic bonds feature a broad distribution of the number of armsinvolved and also display a distribution of net charges peaked around the neutral ionicbond. Our main result is that for charged block length equal to 4 and 5 ionized beadsthe resulting macro-aggregate spans the box and forms a network phase. Furthermore,we investigated the dynamics of ionic bonds, and computed their lifetimes and turing dynamics. The bonds are weak enough to allow a network restructuring underthermal fluctuations but are still strong enough to yield a stable gel phase.