bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic mapping of Schisandra chinensis lignans and their metabolites in rats using a metabolomic approach based on HPLC with quadrupole time‐of‐flight MS/MS spectrometry
Authors: Wang Jiaye , Jiang Bin , Shan Yingying , Wang Xiaoli , Lv Xi , Mohamed Jihan , Li He , Wang Chunmei , Chen Jianguang , Sun Jinghui 
Published: October 2019

AbstractSchisandra chinensis lignans are the main active components of the traditional Chinese medicine Schisandra chinensis in East Asia. At present, there are more and more medicines and health foods in which the total S. chinensis lignans extracts are considered as the main active components, but little research has been done on the active components of S. chinensis lignans in the blood and main target organs. In this study, the components of S. chinensis lignans in the blood, liver and brain tissues of rats at different time points after the intragastrical administration of S. chinensis lignans were determined by a metabolomic method based on high‐performance liquid chromatography with quadrupole time‐of‐flight tandem mass spectrometry spectrometry. Twelve Schisandra chinensis lignans and 15 metabolites in the blood, liver, and brain of rats were identified. The results showed that the main metabolic ways of S. chinensis lignans in rats were hydroxylation, demethylation, and demethylation‐hydroxylation, and some of them might undergo demethylation, dehydrogenation, epoxidation, and elimination reaction. The time‐dose characteristics of S. chinensis lignans and their metabolites in the blood and target organs were analyzed, which may be helpful to elucidate the active substances that really exert the pharmacodynamic effects of S. chinensis lignans in organisms.
Does Operator Experience and the Q‐Box Diameter Affect the Repeatability of Liver Stiffness Measurements Obtained by 2‐Dimensional Shear Wave Elastography?
Authors: Wang Huipeng , Zheng Pengchao , Sang Liang , Wang Xuemei 
Published: October 2019

ObjectivesThe purpose of this research was to evaluate whether operator experience and the quantitative analysis system (Q‐Box; SuperSonic Imagine, Aix‐en‐Provence, France) diameter affect the repeatability of liver stiffness measurements.MethodsWe enrolled 417 outpatients. All measurements were performed by 2 operators, including an expert and a novice. Each patient was continuously measured 3 times by the 2 operators. The Q‐Box diameter was adjusted to 10, 20, and 30 mm each time, and the mean elasticity values were recorded. Intraobserver repeatability was evaluated by the intraclass correlation coefficient (ICC). Interobserver repeatability was evaluated by the ICC, coefficient of variation (CV), and Bland‐Altman plots.ResultsThe study group included 241 male and 176 female patients. The expert operator had higher ICCs than the novice operator at each Q‐Box diameter. The overall interobserver agreement was excellent, and the results showed that compared to other groups, the ICC was the lowest and the CV was the largest for the 30‐mm‐diameter group. The ICC and CV values were similar between the 10‐ and 20 mm‐diameter groups. The Bland‐Altman plots showed that the mean difference was –0.2 kPa for the 10‐, 20‐, and 30 mm‐diameter groups. However, the limits of agreement were the largest in the 30‐mm‐diameter group and were similar between the 10‐ and 20‐mm‐diameter groups.ConclusionsThe repeatability of liver stiffness measurements is affected not only by experience but also by the Q‐Box diameter.
Whole exome sequencing reveals novel CEP104 mutations in a Chinese patient with Joubert syndrome
Authors: Luo Minna , Cao Li , Cao Zongfu , Ma Siyu , Shen Yue , Yang Di , Lu Chao , Lin Zaisheng , Liu Zhimin , Yu Yufei , Cai Ruikun , Chen Cuixia , Gao Huafang , Wang Xueyan , Cao Muqing , Ma Xu 
Published: October 2019

AbstractBackgroundJoubert syndrome (JS, OMIM: 213300) is a recessive developmental disorder characterized by cerebellar vermis hypoplasia and a distinctive mid‐hindbrain malformation called the “molar tooth sign” on axial magnetic resonance imaging. To date, more than 35 ciliary genes have been identified as the causative genes of JS.MethodsWhole exome sequencing was performed to detect the causative gene mutations in a Chinese patient with JS followed by Sanger sequencing. RT‐PCR and Sanger sequencing were used to confirm the abnormal transcript of centrosomal protein 104 (CEP104, OMIM: 616690).ResultsWe identified two novel heterozygous mutations of CEP104 in the proband, which were c.2364+1G>A and c.414delC (p.Asn138Lysfs*11) (GenBank: NM_014704.3) and consistent with the autosomal recessive inheritance mode.ConclusionOur study reported the fourth case of JS patients with CEP104 mutations, which expands the mutation spectrum of CEP104 and elucidates the clinical heterogeneity of JS.
Design of ultra‐wideband antenna with high‐selectivity band notches using fragment‐type etch pattern
Authors: Du Yijun , Wu Xiaopo , Sidén Johan , Wang Gang 
Published: October 2019

AbstractBy specifying objective functions defining the two bands to be notched with high roll‐off criteria (ROCs), optimization searching for the best fragment‐type etch pattern on ultra‐wideband (UWB) antenna is implemented by using multi‐objective optimization. The optimization with too many objective functions requires special treatment to improve the searching efficiency. In this design, two slits are preset on appropriate positions on different sides of the UWB radiator to constrain the decision space for etch pattern searching and yield two initial notched bands to speed up the optimization. For demonstration, a UWB patch antenna is designed with dual‐band notches of ROC = 0.63 at WiMAX band and ROC = 0.65 at WLAN band. Both the simulation and measurement results indicate that there is significant improvement of the selectivity of the dual‐band notches.
Investigating Nonlethal Age Estimation in a Lentic Brook Trout Population
Authors: Taylor Timothy N. , Cross Benjamin K. , Moore Barry C. 
Published: October 2019

Abstract
Routine lethal sampling on small, conservation, or threatened populations may be unsustainable. Therefore, determining if alternative, nonlethal structures can provide accurate age data is important. We evaluated nonlethal structures (scales and pectoral fin rays) in conjunction with otoliths collected from lentic Brook Trout Salvelinus fontinalis in Washington State. We used age-bias plots, percent agreement, and coefficient of variation to determine how scale or fin ray age estimates compared with otolith estimates, which had been validated in a previous study. Prior experience with aging specific structure types was the primary variable affecting age agreement with validated otolith-determined age among three age readers. In general, fin rays and scales did not consistently reflect otolith age. Between-structure coefficient of variation was 17.8–19.1% for scales and fin rays, and between-structure percent agreement (within 1 year) was 80–82%. Individual percent agreement within 1 year was highest (92% and 86% for fin rays and scales, respectively) and coefficient of variation was lowest (9.0% and 14.8%, respectively) for the most experienced reader. Agreement of age estimates between readers improved with experience aging specific structures. Our study suggests that otolith data remains the preferred option.
Is radiotherapy required in first‐line treatment of stage I diffuse anaplastic Wilms tumor? A report of SIOP‐RTSG, AIEOP, JWiTS, and UKCCSG
Authors: Fajardo Raquel Dávila , van den Heuvel‐Eibrink Marry M. , van Tinteren Harm , Spreafico Filippo , Acha Thomas , Bergeron Christophe , de Camargo Beatriz , Oldenburger Foppe , Rübe Christian , Oue Takaharu , Vokuhl Christian , de Krijger Ronald R. , Vujanic Gordan , Sebire Neil , Coulomb‐L'Hermine Aurore , Collini Paola , Gandola Lorenza , Pritchard‐Jones Kathy , Graf Norbert , Janssens Geert O. , van Grotel Martine 
Published: October 2019

AbstractBackgroundAs a significant proportion of relapses occurred in the tumor bed or abdomen on patients with the fifth National Wilms Tumor Study stage I anaplastic Wilms tumor (WT), flank radiotherapy was added for stage I anaplastic WT in the subsequent study of the Children's Oncology Group (AREN0321). Preliminary results revealed reduction of relapse rate and improved survival. In cases treated with preoperative chemotherapy, such as in International Society of Pediatric Oncology (SIOP), the value of radiotherapy has never been studied. The aim of this observational study is to describe the pattern of recurrence and survival of patients with stage I diffuse anaplastic WT (DAWT) after induction chemotherapy.MethodsRetrospective data analysis of the pattern of relapse and survival of all patients with stage I DAWT were included in recent SIOP, L'Associazone Italiana Ematologica Oncologia Pediatrica (AIEOP), Japan Wilms Tumor Study Group (JWiTS), United Kingdom Children's Cancer Study Group (UKCCSG) renal tumor registries. Postoperative treatment consisted of actinomycin D, vincristine, and doxorubicin for 28 weeks without local irradiation.ResultsOne hundred nine cases with stage I DAWT were identified, of which 95 cases received preoperative chemotherapy. Of these, seven patients underwent preoperative true‐cut biopsy. Sixteen of the 95 patients relapsed (17%), six locally, four at distant site, and six combined, and all treated according to SIOP 2001 relapse protocol, which resulted in a 5‐year overall survival of 93%.ConclusionDespite 13% locoregional relapse rate, an excellent rescue rate was achieved after salvage treatment, in patients with stage I DAWT whose first‐line treatment comprised three‐drug chemotherapy (including doxorubicin), without flank irradiation. Therefore, we continue not to advocate the use of radiotherapy in first‐line treatment after preoperative chemotherapy in stage I DAWT in the next SIOP protocol.
Clinical decisions following implementation of asparaginase activity monitoring in pediatric patients with acute lymphoblastic leukemia: Experience from a single‐center study
Authors: Nadeem Komail , Colantonio David , Kircanski Ida , Naqvi Ahmed , Hitzler Johann , Whitlock James A. , Dupuis L. Lee 
Published: October 2019

AbstractWe undertook this retrospective study to describe decisions made following asparaginase activity monitoring implementation at our center. Clinically apparent reactions (CARs) and asparaginase activity monitoring costs were described. Patients with acute lymphoblastic leukemia, aged <18 years who received asparaginase between April 2016 and September 2017, were included. Decisions made following receipt of asparaginase activity results were categorized as continuation, modification, premedication, or discontinuation. We included 129 patients (median age: 5.33 years) receiving 565 asparaginase doses. CARs were observed following 25 asparaginase doses (19/361 [5.3%] pegaspargase). A total of 224 asparaginase activity levels were ordered in 88 patients. Following receipt of 190 asparaginase activity results, asparaginase therapy was continued, modified, or premedicated in 188 (98.9%), 1 (0.005%), and 1 (0.005%) cases, respectively. Inadequate asparaginase activity was observed in three patients receiving Erwinia asparaginase. Asparaginase activity monitoring allowed patients with pegaspargase‐associated CAR and adequate activity to continue therapy unchanged and was cost neutral.
Graphitic carbon nitride (g‐C3N4) reinforced polymer nanocomposite systems—A review
Authors: Gaddam Sashivinay Kumar , Pothu Ramyakrishna , Boddula Rajender 
Published: October 2019

AbstractResearch on polymer matrix‐enhancement using a carbon nanomaterial as the high‐potential filler has attracted considerable attention to meet the increasing demand for advanced polymer composites which show promising applications in a wide variety of fields. Graphitic carbon nitride (g‐C3N4) is the most stable allotrope of carbon nitrides and its inherent electron‐rich properties, basic surface functionalities, and hydrogen bond motifs make it a potential candidate in catalysis and in other fields. This article reviews a new application of graphitic carbon nitride (g‐C3N4) as a reinforcement material into polymer composites. It focuses on the enhancement of tribological, thermomechanical, self‐healing, anticorrosion, and flame‐retardant properties hybrid composite materials via the incorporation of g‐C3N4 filler. The leading purpose of this review is to stress the significance of g‐C3N4 as a reinforcement material in polymer composites.
Keeping the human in the data scientist: Shaping human‐centered data science education
Authors: Anderson Theresa Dirndorfer , Parker Nicola 
Published: October 2019

ABSTRACTHuman‐centered approaches are still relatively novel for data science practice, where data‐driven analytics are often framed as ways to supersede human judgments. This poster presents core design principles devised by the authors to build a data science curriculum foregrounding ethics and valuing creative human capacities alongside strong data analytic skills. The curriculum design transforms human‐centered principles into practice. The poster visually illustrates the trajectory of these principles in relation to three specific graduate attributes, using a selection of deep dives into the learning design. To illustrate the specific power information theory and practice has to shape data science training, the poster uses evocative quotes from information science theorists and displays how their work significantly influenced the overall philosophy of the program, student activities and assessments. Using ‘gamestorming’ techniques during the poster session, the audience is invited to contribute further insights about ways to nurture the deeply human capacities of the data scientists we train.
Connective power of the twitter networks: Discovering the reverse agenda‐setting effects of hashtag activism through topic modeling
Authors: Chong Miyoung 
Published: October 2019

ABSTRACTThe extensive application of social media by the public may signify that the public can play a role in establishing the news media agenda. By rethinking the traditional agenda‐setting theory, the purpose of this study is to investigate whether the public agenda of hashtag activism affected the traditional news media reports about the case of the Alton Sterling shooting. By applying topic modeling and qualitative content analysis, this study examined the agenda of the #AltonSterling Twitter network and concludes that reverse agenda‐setting effects were identified within the one‐day frame between the agendas of the #AltonSterling Twitter network and The New York Times based on high correspondence.
Identification of citation and cited texts for fine‐grained citation content analysis
Authors: Ou Shiyan , Kim Hyonil 
Published: October 2019

ABSTRACTCitation content Analysis is very useful to reveal the nature of citations among scientific papers. However, most of previous studies had been done only from the side of citing papers and ignored the side of cited papers. We proposed a similarity‐based unsupervised citation text identification method and a ranking‐based supervised cited text identification method. Based on the identified citation and cited texts, we performed a fine‐grained citation analysis and found there was a difference in the cited texts between the citing papers in different disciplines.
A survey of data science programs and courses in the iSchools
Authors: Wang Yi‐Yu , Lin Chi‐Shiou 
Published: October 2019

ABSTRACTIn this poster, we examined the current data science programs and courses in the 102 iSchools members. The result shows that the program distribution was unequal by region, and the courses offered by iSchools concentrated on data analysis skills. Research data management, which concerns data management throughout research life cycle and data curation, constituted less than 10% of the courses.
Research on the impact evaluation of academic journals based on altmetrics and citation indicators
Authors: Zhao Rongying , Wang Xu , Liu Zhuozhu , Qi Yongkang , Zhang Zhaoyang , Chang Ruru 
Published: October 2019

ABSTRACTTaking international LIS journals as an example, combining 8 traditional citation indicators and 10 altmetrics indicators, we use the method of multi‐indicator fusion to construct a comprehensive evaluation model of journal impact based on traditional citation indicators and altmetrics indicators. Through normalization processing, correlation analysis, reliability analysis, validity analysis, factor analysis, the paper evaluates the academic impact (FA), societal impact (FS) of LIS journals respectively. We get the following conclusion: (1) We get the 2‐dimensional evaluation results and according to LIS journals impacts, we divide the roles into four categories: “Prestige journals”, “Star journals”, “Common journals” and “Expert journals”. (2) It is found that 8 traditional citation indicators based on JCR, present strong positive correlations, and the indicators are highly consistent overall and internally. (3) There are moderate or high positive correlations among 10 altmetrics based on Altmetrics Explorer, and there are also significant consistency among the indicators as a whole and internally. (4) The correlation coefficient between FA and FS is 0.566, with a moderate positive correlation. It indicates that the evaluation of LIS journals' societal impact based on altmetrics indicators has a useful supplement to the evaluation of academic impact based on citation.
ReTracker: Actively and automatically matching retraction metadata in zotero
Authors: Cheng Yi‐Yun , Parulian Nikolaus , Hsiao Tzu‐Kun , Dinh Ly , Sarol Janina , Schneider Jodi 
Published: October 2019

ABSTRACTRetraction removes seriously flawed papers from the scientific literature. However, even papers retracted for scientific fraud continue to be cited and used as valid after their retraction. Retracted papers are inadequately identified on publisher pages and in scholarly databases, and scholars' personal libraries frequently contain retracted papers. To address this, we are developing a tool called ReTracker (https://github.com/nikolausn/ReTrackers) that automatically checks a user's Zotero library for retracted articles, and adds retraction status as a new metadata field directly in the library. In this paper, we present the current version of ReTracker, which automatically flags retracted articles from PubMed. We describe how we have iteratively improved ReTracker's matching performance through its initial two versions. Our tests show that the current version of ReTracker is able to flag retracted articles from PubMed with high precision and recall, and to distinguish retracted articles from articles about retraction. In its current state, ReTracker can actively and automatically bring retraction metadata into Zotero, and in future work we will test its usability with scholars.
Implications of the embodied, enactive mind on theorizing about information experience
Authors: Hoyte Pamela 
Published: October 2019

ABSTRACTInformation Experience is a recent and growing concept in Information Science that is proposed as a holistic approach to explicitly examine the human experience of information interactions, including an individual's perceptual, cognitive and embodied experience. Valuable to this discussion is setting out a suitable philosophical position about the conception of the mind. This paper proposes that the concepts of embodied cognition and the non‐representational, enactive mind are necessary conceptions of mind for an adequate theoretical account of Information Experience. Furthering this discussion, the concept of information as an enactive cognitive phenomenon is explored, as constructed by the individual, embodied by their experience and contextually situated. These conceptions will provide a foundation for further development of the emerging field of information experience, and prove thought provoking for the Information Science field generally in the development of new approaches to the ways we use and share information in our communities and the future technologies we build for this.
Objectives & key results for active knowledge sharing in IT consulting enterprises: A feasibility study
Authors: Klanwaree Natthakan , Choemprayong Songphan 
Published: October 2019

ABSTRACTObjectives and Key Results (OKRs) have been utilized by numerous leading global enterprises for performance evaluation from a holistic perspective. Nonetheless, the applicability of OKRs for knowledge sharing has been rarely discussed. This paper aims to investigate the feasibility of the adoption of OKRs for active knowledge sharing in IT consulting organizations. As a case study, this project was conducted at an IT consulting organization in Bangkok, Thailand among thirty‐three participants involved in a training session. Some of these participants volunteered to develop their team's OKRs. All participants were interviewed regarding the possibility of adopting OKRs for knowledge sharing based on Technology Acceptance Model (TAM). In general, participants tended to have positive perceptions regarding usefulness, ease of use, trust, and intention to use with some concerns surrounding compatibility with staff who lack creative and leadership personalities. The current study has shed some light on how OKRs may be adopted to support knowledge sharing within organizations.
One of a kind: The tail of citizen science volunteers
Authors: Lee Lo , Darch Peter 
Published: October 2019

ABSTRACTOnline citizen science projects recruit members of the public (volunteers) to contribute to scientific research. Many projects involve volunteers donating processing capacity on their computers to process datasets. Retaining and motivating volunteers is a critical challenge. Existing studies of volunteers identify categories of volunteers, describing the main motivations and contributions of these categories. Based on case studies comprising surveys (n = 2031) and interviews (n = 39) with volunteers in two projects, Einstein@Home and Cosmology@Home, we identify volunteers who do not fit easily into these categories. These volunteers exhibit non‐typical motivations (e.g., getting acknowledgements in scientific publications, and accumulating Gridcoin) or non‐typical contributions (e.g., successfully proposing new lines of work or projects, and conducting and presenting studies of subgroups of volunteers to teams running projects). These volunteers make vital contributions to projects. However, measures taken by project teams based on prior studies of volunteers may be ineffective in retaining and motivating these non‐typical volunteers.
Effects of motivation and tool features on online photo‐sharing behavior
Authors: Cho Hyerim , Smith Josh , Lee Jin Ha 
Published: October 2019

ABSTRACTSharing photos online has become one of the most popular information sharing behaviors in recent years. Due to the plethora of online photo‐sharing websites, applications, and other tools available, we share visual information easily, and quickly. In order to improve our current understanding of photo‐sharing behaviors and identify the exhaustive list of online photo‐sharing motivations, we analyzed 4,555 photos shared online. Seventeen interviewers interviewed 92 participants overall. Twenty photo‐sharing motivations were identified in this study, including To share memory, To disseminate information, For amusement (humor, fun), To show off, and To appreciate beauty/cuteness.