bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?
Authors: Crigna Adriana Torres , Samec Marek , Koklesova Lenka , Liskova Alena , Giordano Frank A. , Kubatka Peter , Golubnitschaja Olga 
Published: October 2020

AbstractInterest in the use of cell-free nucleic acids (CFNAs) as clinical non-invasive biomarker panels for prediction and prevention of multiple diseases has greatly increased over the last decade. Indeed, circulating CFNAs are attributable to many physiological and pathological processes such as imbalanced stress conditions, physical activities, extensive apoptosis of different origin, systemic hypoxic-ischemic events and tumour progression, amongst others. This article highlights the involvement of circulating CFNAs in local and systemic processes dealing with the question, whether specific patterns of CFNAs in blood, their detection, quantity and quality (such as their methylation status) might be instrumental to predict a disease development/progression and could be further utilised for accompanying diagnostics, targeted prevention, creation of individualised therapy algorithms, therapy monitoring and prognosis. Presented considerations conform with principles of 3P medicine and serve for improving individual outcomes and cost efficacy of medical services provided to the population.
Effects of FGFR inhibitors TKI258, BGJ398 and AZD4547 on breast cancer cells in 2D, 3D and tissue explant cultures
Authors: Kähkönen T. E. , Toriseva M. , Petruk N. , Virta A.-R. , Maher A. , Eigéliené N. , Kaivola J. , Boström P. , Koskivuo I. , Nees M. , Tuomela J. M. , Ivaska K. K. , Härkönen P. L. 
Published: October 2020

Abstract
Purpose
Fibroblast growth factor receptors (FGFR) and pathways are important players in breast cancer (BC) development. They are commonly altered, and BCs exhibiting FGFR gene amplification are currently being studied for drug development. Here, we aimed to compare the effects of three FGFR inhibitors (FGFRis), i.e., non-selective TKI258 and selective BGJ398 and AZD4547, on different BC-derived cell lines (BCCs) and primary tissues.

Methods
The human BCCs MCF-7 and MDA-MB-231(SA) (wild-type FGFR) and MFM223 (amplified FGFR1 and FGFR2) were analyzed for FGFR expression using qRT-PCR, and the effects of FGFRis on FGFR signaling by Western blotting. The effects of FGFRis on proliferation, viability, migration and invasion of BCCs were assessed in 2D cultures using live-cell imaging, and in 3D cultures using phenotypic analysis of organoids. To study radio-sensitization, FGFRi treatment was combined with irradiation. Patient-derived BC samples were treated with FGFRis in explant cultures and immunostained for Ki67 and cleaved caspase 3.

Results
We found that all FGFRis tested decreased the growth and viability of BC cells in 2D and 3D cultures. BGJ398 and AZD4547 were found to be potent at low concentrations in FGFR-amplified MFM233 cells, whereas higher concentrations were required in non-amplified MCF7 and MDA-MB-231(SA) cells. TKI258 inhibited the migration and invasion, whereas BGJ398 and AZD4547 only inhibited the invasion of MDA-MB-231(SA) cells. FGFRi treatment of MCF7 and MFM223 cells enhanced the inhibitory effect of radiotherapy, but this effect was not observed in MDA-MB-231(SA) cells. FGFRi-treated primary BC explants with moderate FGFR levels showed a tendency towards decreased proliferation and increased apoptosis.

Conclusions
Our results indicate that, besides targeting FGFR-amplified BCs with selective FGFRis, also BCs without FGFR amplification/activation may benefit from FGFRi-treatment. Combination with other treatment modalities, such as radiotherapy, may allow the use of FGFRis at relatively low concentrations and, thereby, contribute to better BC treatment outcomes.
Employment’s Role in Enabling and Constraining Marriage in the Middle East and North Africa
Authors: Krafft Caroline , Assaad Ragui 
Published: October 2020

Abstract
We investigate the role of employment in enabling and constraining marriage for young men and women in Egypt, Jordan, and Tunisia. Survival analysis methods for age at marriage are applied to comparable labor market panel surveys from Egypt (2012), Jordan (2010), and Tunisia (2014), which include detailed labor market histories. For men, employment and especially high-quality employment are associated with more rapid transitions to marriage. For women, past—but not contemporaneous—employment statuses are associated with more rapid transitions to marriage. After addressing endogeneity using residual-inclusion methods for the case of public sector employment (a type of high-quality employment), we find that such employment significantly accelerates marriage for men in Egypt and women in Egypt and Tunisia. The potential of high-quality employment to accelerate marriage may make queuing in unemployment while seeking high-quality employment a worthwhile strategy.
More self-organization, more control—or even both? Inverse transparency as a digital leadership concept
Authors: Gierlich-Joas Maren , Hess Thomas , Neuburger Rahild 
Published: October 2020

AbstractDigital innovations drive an organization’s digital transformation. While numerous studies focus on digital product and service innovation, digital process innovation and novel business models, management and leadership concepts are primarily investigated as enabling framing conditions in previous contributions. However, management and leadership concepts have changed dramatically in the digital era. The rise of digital technologies has led to companies acquiring large amounts of data. Moreover, novel technical solutions facilitate the analysis and processing of this data, leading to an increase in organizational transparency. Traditional leadership theories fail to explain the influence of digitalization and increasing transparency of leadership. In a digitized world, managers often face a trade-off when using data for management purposes. On the one hand, transparency leads to decreasing information asymmetries, allowing managers to monitor employees’ actions at low cost. On the other hand, employees demand self-organization and empowerment. In this context, new forms of control and employee engagement need to be designed. With our conceptual paper, we aim to provide a solution to the challenges of using transparency in leadership in a mutually beneficial way for managers and employees by introducing the concept of “inverse transparency.” We develop the concept building on the existing literature on transparency and leadership. We see inverse transparency as the basis for a new type of digital innovation, which we introduce as digital leadership innovation. Thus, we enhance current research on leadership approaches and digital innovation and create a theoretical basis for further research.
DFT-Guided Design and Fabrication of Carbon-Nitride-Based Materials for Energy Storage Devices: A Review
Authors: Adekoya David , Qian Shangshu , Gu Xingxing , Wen William , Li Dongsheng , Ma Jianmin , Zhang Shanqing 
Published: October 2020

AbstractCarbon nitrides (including CN, C2N, C3N, C3N4, C4N, and C5N) are a unique family of nitrogen-rich carbon materials with multiple beneficial properties in crystalline structures, morphologies, and electronic configurations. In this review, we provide a comprehensive review on these materials properties, theoretical advantages, the synthesis and modification strategies of different carbon nitride-based materials (CNBMs) and their application in existing and emerging rechargeable battery systems, such as lithium-ion batteries, sodium and potassium-ion batteries, lithium sulfur batteries, lithium oxygen batteries, lithium metal batteries, zinc-ion batteries, and solid-state batteries. The central theme of this review is to apply the theoretical and computational design to guide the experimental synthesis of CNBMs for energy storage, i.e., facilitate the application of first-principle studies and density functional theory for electrode material design, synthesis, and characterization of different CNBMs for the aforementioned rechargeable batteries. At last, we conclude with the challenges, and prospects of CNBMs, and propose future perspectives and strategies for further advancement of CNBMs for rechargeable batteries.
Russia’s Critical Infrastructure Policy: What do we Know About it?
Authors: Pursiainen Christer 
Published: October 2020

AbstractThe article is an analytical state-of-the-art review of the Russian Federation’s critical infrastructure policy, starting from the 1990s but zooming in on the current situation. The article discusses what does critical infrastructure mean in the Russian context. It explores the country’s threat scenarios in this field, and asks what part is played by cyber security threats in this context. Further, the article elaborates the issue whether Russia’s policy is focused on critical infrastructure protection, or has the country adopted the more recent concept of resilience that puts emphasis on adaptive measures and recovery. Finally, it is considered who are the actors in Russian critical infrastructure policy and, in particular, how does Russia deal with the fact that the respective infrastructure operators even in Russia usually are not directly state-owned entities, but private companies.
The Arab Spring and the International Defense Market
Authors: Klomp Jeroen 
Published: October 2020

AbstractThe aim of this study is to analyze the impact of the political violence during the Arab Spring on the stock market return of international defense firms. The direction of this impact is not directly straightforward as the civil unrests influence the expectations of investors in two opposite ways. On the one hand, investors might expect that when the peaceful demonstrations were turned into violent events, the Arab governments involved will start acquiring more military-strategic goods to repress the protests or send a strong signal of power to ensure their stay in office. However, on the other hand, when the popular protests escalated, investors, perhaps, became more concerned about the possible imposition of international military sanctions against the Arab Spring countries to restore peace and protect human rights. The main empirical findings of a dynamic panel model clearly confirm this pattern and point out that when the Arab Spring originated, the abnormal return of international defense stocks starts to rise immediately. However, in the course of time, the concerns of the introduction of arms embargoes become stronger and eventually start to dominate, causing the abnormal return to fall again, while the idiosyncratic risk began to fall due to enhanced diversification. It turns out that firm-specific factors can explain a substantial part of the effect found. For instance, the reaction of investors to the Arab Spring is significantly larger for firms that produce predominantly military goods.
Disability, violence, and mental health among Somali refugee women in a humanitarian setting
Authors: Hossain Mazeda , Pearson Rachel , McAlpine Alys , Bacchus Loraine , Muuo Sheru W. , Muthuri Stella K , Spangaro Jo , Kuper Hannah , Franchi Giorgia , Pla Cordero Ricardo , Cornish-Spencer Sarah , Hess Tim , Bangha Martin , Izugbara Chimaraoke 
Published: October 2020

Abstract

Background
There is limited evidence on the relationship between disability, experiences of gender-based violence (GBV), and mental health among refugee women in humanitarian contexts.

Methods
A cross-sectional analysis was conducted of baseline data (n = 209) collected from women enrolled in a cohort study of refugee women accessing GBV response services in the Dadaab refugee camps in Kenya. Women were surveyed about GBV experiences (past 12 months, before the last 12 months, before arriving in the refugee camps), functional disability status, and mental health (anxiety, depression, post-traumatic stress), and we explored the inter-relationship of these factors.

Results
Among women accessing GBV response services, 44% reported a disability. A higher proportion of women with a disability (69%) reported a past-year experience of physical intimate partner violence and/or physical or sexual non-partner violence, compared to women without a disability (54%). A higher proportion of women with a disability (32%) experienced non-partner physical or sexual violence before arriving in the camp compared to women without a disability (16%). Disability was associated with higher scores for depression (1.93, 95% confidence interval (CI) 0.54–3.33), PTSD (2.26, 95% CI 0.03–4.49), and anxiety (1.54, 95% CI 0.13–2.95) after adjusting for age, length of encampment, partner status, number of children, and GBV indicators.

Conclusions
A large proportion of refugee women seeking GBV response services have disabilities, and refugee women with a disability are at high risk of poor mental health. This research highlights the need for mental health and disability screening within GBV response programming.
A survey of preparedness against coronavirus disease 2019 (COVID-19) in hospitals in Tokyo, Japan, with healthcare personnel with COVID-19 and in-facility transmission
Authors: Tagashira Yasuaki , Takamatsu Akane , Hasegawa Shinya , Uenoyama Yuki , Honda Hitoshi 
Published: October 2020

AbstractA questionnaire was distributed to hospitals in Tokyo (N = 38) regarding their preparedness against and in-facility transmission of coronavirus disease 2019 (COVID-19). As of May 31, 2020, 284 HCP had contracted COVID-19, and in-facility COVID-19 transmission occurred at 13 hospitals, negatively impacting hospital functions and patient care.
United by History: Government Appropriation of Everyday Nationalism During Vladimir Putin’s Third Term
Authors: McGlynn Jade 
Published: October 2020

AbstractDuring Vladimir Putin’s third presidential term, the Russian government and media’s rhetorical embrace of illiberalism, patriotism, and chauvinism was accompanied and partly facilitated by the invocation of historical precedent and “correct” historical understanding. Politicians stressed the importance of a shared historical memory to Russian national identity, rendering the interpretation of history a question of patriotism. The government and state-supportive media then used “patriotic” historical memories to legitimize government policies. Through framing analysis of three significant episodes—namely, the Ukraine Crisis, imposition of sanctions, and Russian intervention in Syria—I outline how the government and state-supportive media conflated these events with supposed historical precedents. This conflation made “patriotic” (or government-approved) history an everyday topic of discussion, but it also confused supporting government policy with celebrating historical triumph (or condemning historical tragedy). In this way, the government co-opted the emotional power of the history they invoked for the purposes of legitimizing their policies. This was compounded by the government and state-supportive media using and citing images and descriptions of ordinary people performing their patriotism in a manner that simultaneously demonstrated awareness of Russian history and support for the government.
Use of stable isotopes in the evaluation of fish trophic guilds from a tropical hypersaline lagoon
Authors: Franco Marcos A. L. , Santos Alejandra F. G. N. , Gomes Abílio S. , de Almeida Marcelo G. , de Rezende Carlos E. 
Published: October 2020

AbstractEnvironmental factors, size-related isotopic changes of the most abundant species and isotopic niche overlap were investigated using stable isotopes in order to evaluate spatial changes of fish trophic guilds in the Araruama Lagoon. Based on 440 muscle samples, 17 fish species were grouped into five trophic guilds. Mean salinity was above 40 at both sites sampled and a significant spatial difference was observed. The highest δ13C mean value was observed for an omnivorous species, whereas the lowest carbon signatures were found for the three fish species belonging to the planktivorous guild. Analysis of the carbon signature of fish species in lower trophic levels showed influence of salinity variation, whilst size appeared to play a role for others. A narrow δ15N difference was observed, but the piscivorous fish species showed the highest δ15N values. The Standard Ellipses Analysis (SEA) detected spatial differences and varying degrees of isotopic niche overlap among trophic guilds, but the percentages of most overlaps (<60%) suggest that, to some extent, the guilds had a unique isotopic niche space. These results are in agreement with data previously reported for the Araruama Lagoon, that found the same prey items with varying relative importance among the most abundant species. Further studies are necessary to understand how the interaction between salinity and other factors, such as migration patterns, changes in prey availability, changes in contribution of primary sources and changes in baseline isotopic signatures could affect the stable isotope signatures shown here.
Stress responses of the green microalga, Dunaliella salina to PEG-induced drought
Authors: Tafvizi Fatemeh , Hosseini Tafreshi Seyed Ali , Toluei Zeinab , Toghyani Mohammad Amin 
Published: October 2020

AbstractDrought stress was evaluated with polyethylene glycol 6000 (PEG 6000) treatment in Dunaliella salina, a microalga known for its great ability to withstand salinities of more than 30%. The aim was to explore the acclimation mechanisms used by the microalga to regulate its growth and physiology during coping with drought stress. The microalga was subjected to culture mediums containing 2 and 5% PEG for 25 days and was compared with a control culture medium. Significant decrease in growth parameters such as specific growth rate, biomass and number of divisions per day was demonstrated in PEG-treated algae. During PEG treatment, chlorophylls slightly increased, while β-carotene and total protein were not affected. Osmolytes, as well as carbohydrates, were found to be significantly higher in PEG-treated algae than in control. Increased catalase and ascorbate peroxidase activities were proportionally related to PEG concentrations in the cultures. The PEG-treated cells accumulated a considerable amount of hydrogen peroxide and malondialdehyde, especially at higher PEG concentrations. Electrolyte leakage increased, regardless of the PEG concentrations applied, while DNA fragmentation was not observed after 25 days of treating with PEG. It was concluded that Dunaliella cells could respond to the drought stress, probably by using a higher accumulation of a range of osmolytes and also more stimulation of the antioxidant enzymatic system.
How nonshared environmental factors come to correlate with heredity
Authors: Beam Christopher R. , Pezzoli Patrizia , Mendle Jane , Burt S. Alexandra , Neale Michael C. , Boker Steven M. , Keel Pamela K. , Klump Kelly L. 
Published: October 2020

AbstractConventional longitudinal behavioral genetic models estimate the relative contribution of genetic and environmental factors to stability and change of traits and behaviors. Longitudinal models rarely explain the processes that generate observed differences between genetically and socially related individuals. We propose that exchanges between individuals and their environments (i.e., phenotype–environment effects) can explain the emergence of observed differences over time. Phenotype–environment models, however, would require violation of the independence assumption of standard behavioral genetic models; that is, uncorrelated genetic and environmental factors. We review how specification of phenotype–environment effects contributes to understanding observed changes in genetic variability over time and longitudinal correlations among nonshared environmental factors. We then provide an example using 30 days of positive and negative affect scores from an all-female sample of twins. Results demonstrate that the phenotype–environment effects explain how heritability estimates fluctuate as well as how nonshared environmental factors persist over time. We discuss possible mechanisms underlying change in gene–environment correlation over time, the advantages and challenges of including gene–environment correlation in longitudinal twin models, and recommendations for future research.
Meal and snack patterns of 7–13-year-old schoolchildren in southern Brazil
Authors: Cezimbra Vanessa Guimarães , Assis Maria Alice Altenburg de , de Oliveira Marina Tissot , Pereira Luciana Jeremias , Vieira Francilene Gracieli Kunradi , Di Pietro Patrícia Faria , Roberto Denise Miguel Teixeira , Geraldo Ana Paula Gines , Soar Claudia , Rockenbach Gabriele , Hansen Fernanda , Hinnig Patrícia de Fragas 
Published: October 2020

AbstractObjective:The aim of the current study was to identify and describe the meal and snack patterns (breakfast, mid-morning snack, lunch, mid-afternoon snack, dinner and evening snack) of public schoolchildren.Design:Cross-sectional study. Information on the previous day’s food intake was obtained through the Web-CAAFE (Food Intake and Physical Activity of Schoolchildren), an interactive questionnaire, which divides daily food consumption into three meals (breakfast, lunch and dinner) and three snacks (mid-morning, mid-afternoon and evening). Each meal contains thirty-one food items and the schoolchildren clicked on the food items consumed in each meal. Factor analysis was used to identify meal and snack patterns. The descriptions of the dietary patterns (DP) were based on food items with factor loads ≥ 0·30 that were considered representative of each DP.Setting:Schoolchildren, Florianopolis, Brazil.Participants:Children (n 1074) aged 7–13 years.Results:Lunch was the most consumed meal (96·0 %), followed by dinner (86·4 %), breakfast (85·3 %) and mid-afternoon snack (81·7 %). Four DP were identified for breakfast, mid-morning snack, lunch, dinner and evening snack, and three for mid-afternoon snack. Breakfast, lunch and dinner patterns included traditional Brazilian foods. DP consisting of fast foods and sugary beverages were also observed, mainly for the evening snack.Conclusions:The results of the current study provide important information regarding the meal and snack patterns of schoolchildren to guide the development of nutrition interventions in public health.
ONE-LEVEL DENSITY OF LOW-LYING ZEROS OF QUADRATIC HECKE L-FUNCTIONS OF IMAGINARY QUADRATIC NUMBER FIELDS
Authors: GAO PENG , ZHAO LIANGYI 
Published: October 2020

AbstractIn this paper, we prove a one level density result for the low-lying zeros of quadratic Hecke L-functions of imaginary quadratic number fields of class number 1. As a corollary, we deduce, essentially, that at least

$(19-\cot (1/4))/16 = 94.27\ldots \%$
of the L-functions under consideration do not vanish at 1/2.