bluuebunny/crossref_metadata_2025_split huggingface dataset:
From low remission to hope: the efficacy of targeted therapies in NUP98-R positive pediatric acute myeloid leukemia
Authors: Xiong Run-Ji , Tang Hong-Xia , Yin Tian-Tian , Pan Hui-Yi , Jin Run-Ming 
Published: February 2025

Abstract

Background
Treating pediatric acute myeloid leukemia (AML) with NUP98 rearrangement (NUP98-R) is challenging. Standard chemotherapy results in low remission rates. This study aimed to evaluate different induction regimens and explore alternative therapies to improve outcomes.

Methods
This retrospective study included 111 pediatric patients with AML treated at our institution from March 2012 to March 2023. Patients were classified into two groups: NUP98-R-positive (n = 10) and NUP98-R-negative (n = 101). We compared their clinical characteristics, treatment responses, and prognoses. Additionally, we presented three cases of NUP98-R-positive patients to elaborate on the role of targeted therapies during induction in treatment outcomes and prognosis.

Results
Patients with NUP98-R fusion genes had a complete remission (CR) rate of 20% after the first induction, which was significantly lower than the 64.3% reported in those without NUP98-R fusion genes (P < 0.05). The 3-year event-free survival (EFS) rate was also lower, with only 30% for NUP98-R patients and 55.3% for non-NUP98-R patients (P < 0.05). The prognosis of NUP98-R patients improved with targeted therapies during induction. For example, Patient 1 achieved CR with FLT3 and BCL-2 inhibitors plus conventional chemotherapy. Patient 2, who was treated with a CDK6 inhibitor, a BCL-2 inhibitor, azacitidine, and an FLT3 inhibitor, also achieved CR and underwent successful stem cell transplantation. Conversely, Patient 3, who received only standard chemotherapy, did not achieve remission and died from a severe infection.

Conclusions
This study demonstrated that using targeted drugs for the induction in NUP98-R pediatric AML improved treatment outcomes. BCL-2, FLT3, and CDK6 inhibitors available at our institution are promising options for this phase of treatment.

Graphical abstract
Fine Classification of Vegetation Under Complex Surface Cover Conditions with Hyperspectral and High-Spatial Resolution: A Case Study of the Xisha Area, Chongming District, Shanghai
Authors: Zheng Bo , Shi Yishao , Wang Qian , Zheng Jianwen , Lu Jue 
Published: February 2025

Abstract
Since both diversity and similarity exist among different vegetation types and since differences and similarities are reflected mainly in geometric morphology and in physical and chemical characteristics, the feedback signals of remote sensors can exhibit both similarities and differences. In vegetation remote sensing, the phenomenon of foreign bodies within the same spectrum is likely to occur. The complex mixed environment of land and water, which is a combination of cultivated land, wetland, woodland, and grassland areas, leads to the occurrence of such problems. In this case, relying on data with a high spatial resolution or high spectral resolution alone cannot effectively improve the accuracy of vegetation classification. Both hyperspectral and high spatial resolutions (H2, with both nanometre spectral resolution and submeter spatial resolution) can ensure that both morphological and spectral characteristics are considered when improving vegetation classification accuracy. In this paper, the Xisha wetland in Chongming and the surrounding cultivated land and forestland areas comprise the experimental area. H2 images with both high spatial and high spectral resolutions were collected using an unmanned aerial vehicle platform. Forty-five plant cover types (and 10 non-vegetation features) were classified according to the spectral features of ground objects. The overall classification accuracy reached 97.86%, and the kappa coefficient reached 0.9725.
Experiences of stigmatization and its impacts among individuals living with hereditary diseases and family members in Portugal: an exploratory study
Authors: Valentim Joana , Paneque Milena , Mendes Álvaro 
Published: February 2025

Abstract
Stigma is defined as the perception of an undesirable attribute that leads to discrimination against individuals and groups. Stigmatisation is often triggered due to visible physical or cognitive differences. Although the literature consistently highlights the (fear of) stigmatisation as a significant concern among individuals living with hereditary conditions, no studies in Portugal have specifically provided evidence on this issue. This study aims to address this gap by examining the experiences and impact of stigma on individuals and families affected by hereditary diseases in Portugal. After receiving ethics approval, a total of 216 participants, including affected individuals, asymptomatic carriers and family members from families with a range of hereditary conditions, were recruited through patient support associations. Participants completed an online questionnaire via Limesurvey. Data were analysed through Exploratory Factor Analysis (EFA), median comparison tests, and thematic analysis. Of the participants, 78.7% were women, 55.6% had a university degree, and 20.4% were aged between 42 and 47 years. Findings indicate that stigma impacts individuals across various domains, including social interactions, institutional settings, the workplace, and healthcare. EFA identified a bi-factorial model of stigma, comprising Stigma Experiences and Perceived Support subscales, and the overall scale demonstrated high internal consistency (α = .879). Women and younger participants reported higher levels of stigma. Religiosity and humor emerged as key coping strategies. This study is the first in Portugal to assess stigma among individuals living with hereditary conditions. Our findings contributed to validating a measurement instrument, identified sociodemographic variations, and examined the psychosocial dimensions of stigma among affected patients. These findings highlight the need for comprehensive strategies to address and mitigate stigma, improve support systems, and enhance the well-being and healthcare experiences of individuals and families impacted by hereditary diseases.
Ultrasound-guided small-bore chest drain placement: a retrospective analysis of feasibility, safety and clinical implications in internal medicine ward
Authors: Boccatonda Andrea , Tallarico Viola , Venerato Stefano , Serra Carla , Vicari Susanna 
Published: February 2025

Abstract

Purpose
Massive and complex pleural effusions represent a frequent challenge for internists, particularly when patients present with significant symptoms and the hospital setting lacks dedicated thoracic surgery or interventional pneumology services.

Methods
This retrospective study evaluates the effectiveness and feasibility of ultrasound-guided small-bore chest drain placement performed by internal medicine physicians with interventional ultrasound experience. We analyze procedural success rates, complication profiles, and subsequent clinical management in a cohort of patients managed in a single internal medicine ultrasound ward.

Results
In our series of ten patients, ultrasound-guided drain placement was successful in all cases. No immediate major complications were encountered, and subsequent complications were minimal and manageable.

Conclusion
Ultrasound-guided small-bore chest drain placement is a feasible, safe, and effective alternative to surgical chest tube insertion in selected patients in internal medicine wards, potentially avoiding the need for hospitalization or transfer to specialized thoracic surgery services.
Patient Safety Events Among People from Ethnic Minority Backgrounds: A Retrospective Medical Record Review of Australian Cancer Services
Authors: Chauhan Ashfaq , Joseph Kathryn , Chin Melvin , Pitcher Meron , Wilson Carlene , Manias Elizabeth , Ozavci Guncag , Gan Hui , Newman Bronwyn , Walpola Ramesh Lahiru , Seale Holly , Walsan Ramya , Harrison Reema 
Published: February 2025

Abstract

Objectives
People from ethnic minority backgrounds are exposed to greater risk of patient safety events (such as healthcare-acquired infections and medication errors) occurring in their healthcare. However, evidence of the type and frequency of patient safety events occurring in cancer care among patients from ethnic minority background is lacking. This study sought to address this evidence gap.

Design
A two-stage retrospective medical record review was conducted at four cancer services in two Australian states. Eligible medical records at each service that were identified as belonging to ethnic minority patients were reviewed by two clinician researchers in stage one, followed by authentication of extracted data by a site-specific cancer clinician in stage two. Descriptive statistics were used to report the frequency and type of safety events. Chi-square and independent sample T-tests were used to examine the association between safety events and patient socio-cultural indicators.

Results
A total of 628 patient records were included. Of the 628 patient records, 212 (33.75%) documented at least one safety event. A total of 410 safety events were documented in the 212 patient records. Medication-related safety events were most commonly documented (121/410, 29.5%), followed by clinical process/procedure-related safety events (76/410, 18.5%) and patient accidents (60/410, 14.6%). The occurrence of a safety event was associated with patient records that documented ‘no interpreter was required’.

Conclusion
Patient safety events in cancer care occur frequently among patients from ethnic minority backgrounds. Unsafe cancer care for this population is associated with inadequate use of interpreters, lack of shared understanding and expectations of care processes linked to cultural and linguistic barriers. Approaches to enhance engagement are required.
Diagnostica medico nucleare del carcinoma midollare tiroideo
Authors: Giovanella Luca 
Published: February 2025

Sommario
Il carcinoma midollare della tiroide (CMT) è un tumore maligno derivato dalle cellule C parafollicolari della tiroide. Può presentarsi in forme sporadiche o ereditarie e la chirurgia rappresenta la cura primaria. L’esame ecografico e, in casi selezionati, le procedure di imaging anatomico vengono adottate per stadiare la malattia prima dell’intervento chirurgico primario, mentre diverse procedure di imaging anatomico/morfologico e funzionale/molecolare possono essere adottate per rilevare la malattia persistente/ricorrente. I radiofarmaci emettitori di positroni, tra cui fluoro-18 fluorodesossiglucosio (18F-FDG), fluoro-18 diidrossifenilalanina (18F-FDOPA) e analoghi della somatostatina marcati con gallio-68 (68Ga-SSA) si sono dimostrati utili per rilevare recidive/metastasi del CMT. La presente review illustra i principali radiofarmaci per imaging a positroni impiegati nei pazienti affetti da CMT e fornisce indicazioni pratiche per un razionale utilizzo clinico.
Selective Gold Recovery with Electrochemically Assisted Aqueous Reduction
Authors: Herrala Reima , Yliniemi Kirsi , Vapaavuori Jaana , Lundström Mari 
Published: February 2025

Abstract
The recovery of valuable and rare metals from complex feeds has become increasingly important to realize more circular hydrometallurgical processes. Electrochemical methods are an attractive option as they typically do not require chemical addition; however, competing reactions may lead to low current efficiencies. Therefore, targeted methods like electrodeposition-redox replacement (EDRR) and more recently electrochemically assisted aqueous reduction (EAR) have been developed. This work studies for the first time the impact of oxidants (Cu, Fe), passive base metals (Ni, Zn, Al) and precious metals (Pd, Pt, Ag)—commonly found in hydrometallurgical process streams—on gold recovery through EAR. The study is carried out with synthetic solutions simulating chloride leachates, where the impact of each metal impurity is first studied individually and then from a combined solution. High oxidant concentrations are observed to be detrimental for process efficiency, but the electrochemical pulse parameters can be adjusted to compensate. Finally, electrochemical quartz crystal microbalance analysis and deposit characterization reveals high selectivity for gold recovery from a combined multimetal solution.

Graphical Abstract
Vom Glauben zur Radikalisierung: Eine empirische Analyse des Zusammenspiels von Radikalisierungsanfälligkeit, religiösem Fundamentalismus und der Akzeptanz von Gesetzesverstößen und Gewalt
Authors: Küchler Armin C. D. , Öztürk Cemal , Kurtenbach Sebastian , Pickel Susanne 
Published: February 2025

Zusammenfassung
Die Komplexität der Gründe für Radikalisierung und deren Einfluss auf die Neigung zur Rechtsverletzung und Gewaltausübung sind von bedeutender Tragweite für gesellschaftliche Gefüge sowohl in Deutschland, Europa als auch global. Dieser Beitrag analysiert den Einfluss von religiösem Fundamentalismus auf radikale Handlungsabsicht und untersucht dabei die Rolle von drei ausgewählten Risikofaktoren: Diskriminierungserfahrungen, Autoritarismus und Demokratiemisstrauen, die zu einem Index der Anfälligkeit für Radikalisierung zusammengefasst werden. Anhand einer empirischen Auswertung einer Umfrage unter Muslimen in Deutschland wird untersucht, ob eine Korrelation zwischen religiösem Fundamentalismus, der Anfälligkeit für Radikalisierung und radikaler Handlungsabsicht selbst besteht. Die Ergebnisse einer Mediationsanalyse legen nahe, dass Anzeichen für Radikalisierungsanfälligkeit ernst genommen werden sollten, da sie sich sowohl direkt als auch indirekt über eine gesteigerte Empfänglichkeit für religiösen Fundamentalismus auf die Akzeptanz von Rechtsverstößen und Gewalt auswirken können.
Towards Shaping Integrated Circular Economy Approaches in Animal Breeding Supply Chains by Mainstreaming Microalgae Utilization
Authors: Giakoumatos Stephanos D. V. , Tsoulfas Giannis T. 
Published: February 2025

Abstract
This paper presents a comprehensive literature review and analysis of sustainable biomass exploitation strategies, focusing on agro-waste residues and animal excreta. The research explores potential microalgal cultivation and utilization as a promising, low-energy alternative biomass source. While many production pathways are technologically feasible, their commercial viability under current market conditions is limited. The study aims to highlight sustainable water and biomass treatment methods and identify potential obstacles preventing agro-entrepreneurs from adopting integrated, viable algal-derived biomass exploitation. These strategies could contribute to greenhouse gas (GHG) mitigation, aligning with UN targets and EU legislation for a sustainable future. An extensive literature review was carried out over relative algae exploitation issues. A synthesis of techniques, innovative technologies and strategies were recorded so as to aim minimized mass and energy flux towards sustainable pathways. The proposed solutions, including soft water reclamation and novel biomass production, utilize well-established techniques and significant operational parameters for smart circular biomass flows. These approaches are interrelated to agribusiness and contribute to replenishing carbon and nitrogen surface pools, enabling better emission control and overall energy savings. The study emphasizes the potential for synergies in organized activities, such as co-locating cattle farms, greenhouses, and biogas plants to produce sustainable energy and create agri-biomass-based clusters with remarkable operational autonomy. The findings suggest that there are various areas of biomass exploitation which are quite promising in terms of embracing circular economy approaches and mitigating negative impacts in the agribusiness industry.
Effects of physical soil and water conservation structures and slope gradients on selected soil properties in Ijara watershed, Nonno district, West Shewa, Ethiopia
Authors: Debisa Alemayehu , Regasa Tena , Mammo Siraj 
Published: February 2025

Abstract
Effective watershed development and management contribute significantly to the sustainable development goals by promoting sustainable livelihoods, bolstering resilience, and safeguarding natural resources. Implementing watersheds using physical soil and water conservation (PSWC) measures is one of the mechanisms employed to halt soil erosion and associated nutrient loss. However, no empirical study has been conducted to examine the effects of Physical Soil and Water Conservation (PSWC) structures and varying slope gradients on selected soil properties in the Ijara watershed, located in the Nonno district of Oromia, Ethiopia. Hence, this study was carried out to assess the influences of PSWC structure and slope gradients on selected soil physicochemical parameters in the study watershed. The research employed a Randomized Complete Block Design technique to collect soil data. A total of 18 composite soil samples were collected from the top 20 cm of soil depth in farmland with and without PSWC structures across three landscape positions. The General Linear Model(GLM) was applied to test the influence of environmental factors on soil physicochemical properties, using the SPSS computer program software version 25. The results showed that sand particles, clay particles, Moisture, Total Nitrogen(TN), Cation Exchangeable Capacity (CEC), Soil Organic Matter, and Soil Organic Carbon, Exchangeable Calcium and Potassium were significantly varied across various watershed management practices (p < 0.05) due to the conservation practice. Bulk Density(BD), Moisture Content, Electro Conductivity, CEC, TN, and Exchangeable P and M showed a significant (p < 0.05) variation related across slope gradients. Except for sand particles and bulk density (BD), the mean values of all analyzed soil properties increased from the upper to the lower slope. The study results have revealed that implementing PSWC measures in the farmland significantly improved most of the physicochemical parameters of the soil compared to the farmland without PSWC measures. In the study area, the stone bund structures of the watershed reduced soil erosion problems and had desirable effects on soil physicochemical properties, improving the land’s productive capacity. Responsible bodies are expected to provide technical support, training, and follow-ups for farmers in the study area to manage the watershed better.
Macroscopic quantum tunnelling of a Bose-Einstein condensate in a Cubic-Plus-Quadratic Well
Authors: Liu Rui-Bin , Liu Mingyang , Zhang Shizhong 
Published: February 2025

Abstract
We study the macroscopic quantum tunnelling of an interacting Bose-Einstein condensate in a cubic-plus-quadratic well that was approximately realized in recent experiment. We utilise the Gross-Pitaevskii equation and Wentzel-Kramers-Brillouin (WKB) method to investigate the effect of the inter-atomic interactions on the tunnelling rate of a quasi-bound condensate. We find that the existence of repulsive interaction enhances the quantum tunnelling of a trapped Bose-Einstein condensate.
Climate change projections and hydrological modelling to predict the streamflow in Berach-Banas catchment, Rajasthan
Authors: Pareta Kuldeep , Dashora Yogita 
Published: February 2025

Abstract
This study investigates the impact of climate change on streamflow dynamics in the Berach-Banas catchment of Rajasthan through climate projections and hydrological modeling. This study employs the MIKE Hydro River and NAM (Nedbor-Afstromings Model) Rainfall-Runoff modules, integrating data from 14-meteorological stations and two streamflow stations (Chittorgarh and Bigod) for period 2000–2022. Climate projections are derived from the CMIP6 (Coupled Model Intercomparison Project Phase 6) under the SSP2-4.5 (Shared Socioeconomic Pathways) scenario for the period 1951–2100. Sixteen downscaled Global Climate Models (GCMs) from various institutes are utilized to simulate future conditions for 2030, 2050, and 2090. The hydrological model incorporates ten water storage structures and delineates the catchments into 13 sub-catchments. The calibration period (2011–2015) demonstrated strong model performance at Chittorgarh (R2 = 0.92 with a water balance error (WBL) of 1.41%) and Bigod (R2 = 0.95, WBL of 0.99%). Similarly, the validation period (2017–2022) exhibited good performance at Chittorgarh (R2 = 0.91, WBL = 1.64%) and Bigod (R2 = 0.94, WBL = 1.13%). Sensitivity analysis identified CQOF (overland flow runoff coefficient), CK1,2 (time constants for routing overland flow), and Lmax (maximum water content in root zone storage) as critical parameters, consistent with findings from previous studies on Indian river basins. The climate change impact analysis indicated a consistent increase in streamflow rates for 2030, 2050, and 2090 compared to 2022, likely driven by rising temperatures and changes in precipitation patterns. The projected increase in streamflow rates underscore potential future challenges for water management, highlighting the need for effective adaptation strategies. The novelty of the study lies in its comprehensive integration of future climate scenarios with hydrological modeling, offering valuable insights for sustainable water resource planning in the region. The results highlight the substantial hydrological changes anticipated in the coming decades, enhancing the overall understanding of climate change impacts on water systems.
Predictive authoring for Brazilian Portuguese augmentative and alternative communication
Authors: Pereira Jayr , Nogueira Rodrigo , Zanchettin Cleber , Fidalgo Robson 
Published: February 2025

AbstractIndividuals with complex communication needs often rely on augmentative and alternative communication (AAC) systems to have conversations and communicate their wants. Such systems allow message authoring by arranging pictograms in sequence. However, the difficulty of finding the desired item to complete a sentence can increase as the user’s vocabulary increases. This paper proposes using BERTimbau, a Brazilian Portuguese version of Bidirectional Encoder Representations from Transformers (BERT), for pictogram prediction in AAC systems. To fine-tune BERTimbau, we constructed an AAC corpus for Brazilian Portuguese to use as a training corpus. We tested different approaches to representing a pictogram for prediction: as a word (using pictogram captions), as a concept (using a dictionary definition), and as a set of synonyms (using related terms). We also evaluated the usage of images for pictogram prediction. The results demonstrate that using embeddings computed from the pictograms’ caption, synonyms, or definitions have a similar performance. Using synonyms leads to lower perplexity, but using captions leads to the highest accuracies. This paper provides insight into how to represent a pictogram for prediction using a BERT-like model and the potential of using images for pictogram prediction.