bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intention to Use Long Acting and Permanent Contraceptive Methods and Associated Factors in Health Institutions of Aksum Town, North Ethiopia
Authors: Syum Hailay , Kahsay Gizienesh , Huluf Teklehaymanot , Beyene Berhe , Gerensea Hadgu , Gidey Gebreamlak , Desta Haftom , Abay Mebrahtu , Nuguse Haben , Haile Kebede 
Published: November 2019

Abstract
Objective: In Ethiopia, the majority of married women practice predominantly short-acting contraceptive methods. Therefore this study aims to assess intention to use LAPMs and its determinants among short-acting users in Health Institutions of Aksum Town, North Ethiopia. Results: Prevalence of intention to use LAPMs was 52.1% (95% CI: 47.4-57.0). Good knowledge on LAPMs [AOR=2.15; 95% CI (1.29,3.56)], positive attitude towards LAPMs [AOR=3.41; 95% CI (1.99,5.85)], 18-24 years of age [AOR=3.18; 95% CI (1.30,7.79)], being primary school in educational level [AOR=0.34; 95% CI (0.14,0.78)], decision on the number of children jointly with partner [AOR=2.05; 95% CI (1.01,4.18)], having more than two children [AOR=10.67; 95% CI (1.29,88.31)], and no [AOR=10.21; 95% CI (3.10,33.58)] and one [AOR=4.70; 95% CI (1.68,13.13)] extra number of children desired were factors significantly associated with having intention to use LAPMs compared to their counterparts. The intention to use LAPMs was low. Therefore, appropriate information, education and communication strategies must be designed to raise awareness and change the negative attitude of the community on LAPMs. Keywords: LAPMs, intention to use, factors, Axum, Ethiopia
Incidence Trend of Breast Cancer in Women of Eastern Mediterranean Region countries from 1998 to 2019: A Systematic Review and Meta-Analysis
Authors: Zahedi Razieh , Vardanjani Hossein Molavi , Baneshi Mohammad Reza , Haghdoost Ali Akbar , Afshar Reza Malekpour , Sarabi Roghayeh Ershad , Tavakoli Ftemeh , zolala farzaneh 
Published: November 2019

Abstract
Background This study was conducted to provide evidence on the current status of breast cancer and its incidence trend in Eastern Mediterranean Region during 1998-2019. Also, this study aimed to investigate the association between the incidence of breast cancer and Human Development Index and some factors related to this index, including total fertility rate, and obesity, using a meta-analysis. Method Data on incidence of breast cancer were collected from various sources, including PubMed, Embase, Web of Science, and WHO, from 1998 to 2019 using systematic review and meta-analysis. Pooled age standardized rate was calculated based on study duration and quality of data using a subgroup analysis and random effect meta-analysis. Results A total of 80 studies (545 data points) were analyzed. Pooled age standardized rate of breast cancer for Eastern Mediterranean Region was 37.1 per 100 000 person-year (95% confidence interval [CI], 34.5, 39.8) during 2011-2019. age standardized rate of breast cancer had an upward trend in Eastern Mediterranean Region from 2005 to 2019. However, the increasing trend was found to be slightly different in various regions based on quality of data. Moreover, pooled age standardized rate had a significant association with Human Development Index [-89.2 (95% CI, -119.8, -58.7)] and obesity [1.2 (95% CI, 0.9, 1.5)]. Conclusion Pooled age standardized rate of breast cancer in Eastern Mediterranean Region was lower than the global average. Also, the age standardized rate value and its incremental trend have been higher in countries with high-quality data than in other countries of this region in recent years. Data quality or physiological factors, such as increase in obesity rates, could be the reasons for this incremental trend.
A pilot trial on lithium disilicate partial crowns using a novel prosthodontic Functional Index for Teeth (FIT)
Authors: Cagidiaco Edoardo Ferrari , Grandini Simone , Goracci Cecilia , Joda Tim 
Published: November 2019

Abstract
Background Lithium disilicate is now a well accepted material for indirect restorations. The aim of this trial was to evaluate two lithium disilicate systems using a novel prosthodontic Functional Index for Teeth (FIT).Methods Partial adhesive crowns on natural abutment posterior teeth were made on sixty patients (clinicaltrial.gov # NCT 01835821). Patients were divided into two groups: Group 1 e.max press (Ivoclar), Group 2 LiSi press (GC Co.). The restorations were followed-up for 3 years. The FIT is composed of seven variables (Interproximal, Occlusion, Design, Mucosa, Bone, Biology and Margins), each of them to be evaluated using a 0-1-2 scoring scheme. The Mann-Whitney ‘U’ test was applied. The level of significance was set at p<0,05.Results Survival rate was 100%, without any biological or technical complication. No statistically significant difference emerged between the two groups in any of the assessed variables (p>0.05).Conclusions The results showed that it is possible to evaluate the clinical performance of partial crowns using FIT. The FIT proved to be an effective tool to foresee the possible risk of failures and to monitor the performance of the restorations at each recall. The two lithium dislocate materials showed same results after 3 years of clinical service.
Musculoskeletal Symptoms among Radiologists in Saudi Arabia: A Multi-Center Cross-Sectional Study
Authors: Shammari Malak Al , Hassan Ali , Dandan Omran Al , Gadeeb Mohammed Al , Bubshait Dalal 
Published: November 2019

Abstract
Background : Musculoskeletal symptoms account for the majority of work-related illnesses resulting in a significant economic burden on society. Computer users are subject to unique repetitive strains that predispose them to musculoskeletal symptoms. In the digitalized field of radiology, radiologists spend long hours interpreting medical images on computers. This study aimed to determine the prevalence of musculoskeletal symptoms among radiologists in Saudi Arabia and their contributing factors.
Methods : An online survey was sent to radiologists in all hospitals (academic, public and private) in the major cities of the Eastern Province of Saudi Arabia covering demographic characteristics, workload (e.g. the time spent at a computer workstation), and workstation environments including the number of monitors as well as the adjustability of the height of the workstation and the viewing distance. This survey of 263 radiologists was conducted in April 2019. It included an evaluation of musculoskeletal symptoms using the Nordic Musculoskeletal Questionnaire. The study outcome was the presence of disabling musculoskeletal symptoms in any body region, which restricted the performance of normal activities in the last 12 months. Results were analyzed descriptively using a Chi-square test and logistic regression analysis to estimate the odd ratio of experiencing disabling musculoskeletal symptoms in the last 12 months.
Results : The survey was completed by 198 participants (111 men and 87 women) with a response rate of 75.3%. Most participants (71.2%) were aged below 40 years. A multivariate logistic regression analysis revealed being a female radiologist (OR = 2.7; 95% CI: 1.2–6.5), aged 30–39 years (OR = 4.1; 95% CI: 1.1–15.3), and predominantly reviewing computed tomography (CT) images (OR = 4.1; 95% CI: 1.4–12.3) or ultrasound scans (OR = 5.9; 95% CI: 1.4–25.3) were associated with higher prevalence of disabling musculoskeletal symptoms, compared to those aged below 30 years and those who reviewed various imaging modalities, respectively.
Conclusions : Musculoskeletal symptoms are common among radiologists with lower back and neck pain being the most frequent complaints. Being a female radiologist, aged 30–39 years, and reviewing CT or ultrasound scans were associated with higher rates of disabling musculoskeletal symptoms.
Effect of Calcium on the Interaction of Acinetobacter baumannii with Human Respiratory Epithelial Cells
Authors: Chen Yi , Shao Tingjun , Fang Sanhua , Pan Ping , Jiang Jiahui , Cheng Tongtong , Wan Haitong , Yu Daojun 
Published: November 2019

Abstract
Background: Investigating the factors that influence Acinetobacter baumannii(Ab) adhesion/invasion of host cells is important to understand its pathogenicity. Metal cations have been shown to play an important role in regulating the biofilm formation and increasing the virulence of Ab; however, the effect of calcium on host-bacterial interaction has yet to be clarified. Here, the dynamic process of the interaction between Ab and human respiratory epithelial cells and the effect of calcium on host-bacterial interaction were explored using microscopic imaging, quantitative PCR and real time cellular analysis (RTCA).
Results: The concentration of calcium, multiplicity of infection and co-culture time were all demonstrated to have effects on host-bacterial interaction. A unique "double peak" phenomenon changed to a sharp "single peak" phenomenon during the process of Ab infection under the effect of calcium was observed in the time-dependent cell response profiles. Moreover, calcium can increase Ab adhesion/invasion of epithelial cells by regulating the expression of Ab-related genes (ompA, bfmRS, abaI).
Conclusions: Effective control of calcium concentrations can provide new approaches for the prevention and treatment of multi-drug resistant Ab.
Developing a High-Performance Liquid Chromatography Fast and Accurate Method for Quantification of Silibinin
Authors: Bakhshi Faezeh , Molavi Ommoleila , Rashidi Mohammad Reza , Shayanfar Ali , Amini Hassan 
Published: November 2019

Abstract
Objective : Silibinin is an antioxidant agent and is shown to have anticancer effects in different cancers including lung, breast, colorectal, liver, prostate, and kidney. There are challenges in the clinical use of silibinin. The main limitation is low solubility, poor oral absorption, and extensive hepatic metabolism. We aim to develop a High-Performance Liquid Chromatography (HPLC) sensitive method for quantification of silibinin in aqueous samples to quantify its concentration in new formulations. A reverse-phase high-performance liquid chromatography (RP-HPLC) composed of C18 column as stationary phase and the mixture of methanol (90%) and water (10%) as mobile phase. The developed method was validated based on the established guidelines. Results : The retention time for silibinin was seen in 2.97 minute after injection. The calibration curve was drawn and the established method demonstrated a linear ranged from 10 to 100 µg/ml, with a correlation coefficient of 0.996. The sensitivity of the developed method was 10 µg/ml. The accuracy calculated in the range of 88-105.9% and the precision (as relative standard deviation) was between 2.7-10.9%. These results demonstrate that the developed method can be a fast and accurate method for quantification of silibinin in aqueous samples.
Overweight and Obesity among children under five in Ethiopia: Further Analysis of 2016 National Demographic Health Survey: A Case Control Study
Authors: Weldearegay Haftom Gebrehiwot , Gebrehiwot Tesfay Gebregzabher , Abrha Mulugeta Woldu , Mulugeta Afework 
Published: November 2019

Abstract
Objective

The objective of this study was to assess the determinants of overweight and obesity among children under five years in Ethiopia.

Results

Data from a total of 672 (224 cases and 448 controls) under five years of age children were included in the study. Urban residence (AOR = 2.63, 95% CI: 1.29, 5.34), boys (AOR = 1.56, 95% CI: 1.10, 2.22) and age of the child less than six months (AOR=3.40, 95%CI: 2.05, 5.64) were the determinants for being childhood overweight and obesity.
Prevalence and risk factors of active trachoma among rural preschool children in Wadla district, Northern Ethiopia
Authors: Kassaw Mesfin Wudu , Abebe Ayele Mamo , Tegegne Kirubel Dagnaw , Getu Mikiyas Amare , Bihonegn Woldemichael Tadesse 
Published: November 2019

Abstract
Background፡Trachoma is the neglected eye problem and the primary cause of preventable corneal blindness. In endemic areas, an initial infection can occur in early childhood, and when there is recurrence, it progresses to scarring and blindness. In the past certain decades, trachoma eliminated from developed countries through enhancements of hygiene and sanitation under immense commitments of the governments but still a problem of developing countries. Studies and reports also indicated that the Amhara region had the highest prevalence of trachoma of the other regions in Ethiopia. Thus, the aim of this study was to asse{Birlie, 2016 #48}ss prevalence and risk factors of active trachoma among rural preschool children in Wadla district, Amhara region, north Wollo zone, northern Ethiopia. Methods: Although the sample size was 583, a total of 596 children were screened for signs of active trachoma because of the sampling procedure nature, cluster sampling technique. Wadla district was had 150 rural villages, which were similar in topography and socio-demographic status. Of these villages, 30 were selected randomly as sites of data collection. An interview on the socio-demographic status with heads of households was held by health informatics professionals. The interview questioners were prepared through reviewing the literature and pretested in Meket Woreda. Eye examination was performed by integrated Eye care workers who were trained for one month for the purpose of trachoma screening. They were also involved in two national trachoma surveys as trachoma sign graders for Carter center-Ethiopia. Results - The prevalence of active trachoma among rural pre-school children in Wadla district was 130 (21.8%). On logistic regression, poor economic status (AOR (95% CI), (3.8 (1.3-11.4), being in 37- 48 months old (AOR (95% CI), (4.2 (1.5-12.0), lived in thatched house roof (AOR (95%CI), (4.4 (1.4-13.6), presence of fly in nearby home (AOR (95% CI), 4.6 (2.1-9.9), once weekly face washing frequency (AOR (95% CI), 8.6 (2.5-29.3), unwashed child’s face for longer than a week (AOR (95% CI), 10.6 (2.9-37.7), not using soap while washing children’s hand (AOR (95% CI), 4.5 (1.8-11.3), and absence of latrine (AOR (95% CI), 5.1 (2.0-12.9) were had association with active trachoma
An alarming rise of non-albicans Candida species and uncommon yeasts in the clinical samples; a combination of various molecular techniques for identification of etiologic agents
Authors: Taei Mohireh , Chadeganipour Mostafa , Mohammadi Rasoul 
Published: November 2019

Abstract
Objective: Yeasts are unicellular microorganisms may cause systemic infection in immunocompromised patients. The aim of this study was to identify yeast strains isolated from clinical specimens using molecular techniques.
Results: A total of 202 yeast strains isolated from 341 clinical samples between February 2017 and May 2019. All clinical isolates were identified using phenotypic and molecular tests including PCR-RFLP, duplex-PCR, multiplex-PCR, and PCR-sequencing. The most yeast fungal isolates were obtained from urine (66.8%), nail (9.4%), skin lesion (7.9%), bronchoalveolar lavage (5.9%), and blood (3.9%). One hundred and twenty-one Candida species were identified as non- albicans versus 76 Candida albicans. Trichosporon asahii, and Pichia terricola were uncommon non- Candida yeasts isolated from urine samples. For the first time, we isolated P. terricola as etiological agent of urinary tract infection in a pregnant female. Since Candida species show different levels of resistance to antifungal agents, precise identification of clinical isolates is critical for better treatment of infection.
High-throughput sequencing analysis of intestinal flora changes in elderly hemodialysis CKD patients
Authors: liu yan , Hu Jianguang , Zhong Xiaoshi , Yan Jing , Zhou Daoyuan , Qin Danping , Xiao Xiao , Zheng Yuanyuan 
Published: November 2019

Abstract
Background Chronic kidney disease (CKD) disease affects gut flora by causing dysbiosis and lead to systemic inflammatory conditions. Here, we provide intestinal flora changes of CKD patients undertook different hemodialysis therapy.Methods Patients were recruited during 2017-2019 and divided into healthy control group (CT), CKD non-dialysis group (CKD), hemodialysis group (HD) and peritoneal dialysis group (PD). Intestinal flora genome 16S rDNA sequencing and further bio-informatic analysis were performed.Results Decreased diversity and altered communities of intestinal flora in PD patients, in which microbial diversity was positive correlated with the albumin level were observed. A total of 20 intestinal flora phyla were detected in 166 fecal samples, divided into 3 dominant intestinal types including Bacteroides-dominant gut type, Firmicutes-dominant type and Proteobacteria-dominant gut type. Further analyses found 198 genera, the abundance of 86 genera were significantly different. Butyrate-producing taxa as Faecalibacterium in genera level and Bifidobacteriaceae and Prevotellaceae in family level were dominant genus in CT, CKD, and HD groups, while urease containing-, indole- and p-cresol-forming taxa as Escherichia in genera and Enterobacteriaceae , Enterococcaceae in family level was dominated genus in PD group. Number of differential expressed genes in KEGG enrichment pathways were significantly different in PD group in carbohydrate metabolism, amino acid metabolism, energy metabolism, translation, and membrane transport.Conclusion Our results suggest peritoneal dialysis therapy could result in reduced diversity and altered microbial communities, with reduced probiotic butyrate-producing taxa and increased urease containing-, indole- and p-cresol-forming taxa. The disordered intestinal flora can seriously affect the nutrition level in CKD patients with PD therapy.
Global Competence of Medical Students: An Assessment Scale and Preliminary Investigation in China
Authors: Shi Yue , Du Huakang , Feng Yunying , Cao Yihan , Zhang Haiyang , Ding Yingjing , Zhao Yi , Zhang Lihan , Li Peifan , Cai Sicheng , Li Tong , Cui Naiqian , Wu Haojie , Zhao Jun 
Published: November 2019

Abstract
Background: The importance of global competence has been acknowledged in medical care as well as medical education. However, the existing definition of global competence and the survey tools used to assess global competence are not fully applicable to medical students. This study developed and validated a questionnaire assessing the global competence of medical students and preliminarily explored the underlying factors influencing the global competence of Chinese medical students in eight-year programs.
Methods: A questionnaire (Global Competence Assessment Scale for Medical Students, MS-GCAS) was developed following a systematic process, and a cross-sectional multicenter survey was conducted among 10 medical schools in China. A total of 1062 completed questionnaires were analyzed.
Results: The analysis revealed a four-factor scale consistent with the proposed structure according to the definition of global competence. The validity estimates of the four subscales were mostly satisfactory. School education, duration of overseas exchange programs and willingness to work abroad were found to have significant correlations with global competence.
Conclusions: The MS-GCAS is valid and reliable for the assessment of the global competence of medical students in China. Medical schools should take further steps to promote medical students’ global competence.
Pharmacists’ knowledge attitude and practice regarding the dispensing of antibiotics without prescription in Tanzania: an explorative cross-sectional study
Authors: Poyongo Baraka P , Sangeda Raphael Zozimus 
Published: November 2019

Abstract

Background:
Inappropriate use of antibiotics has been reported to contribute to the emergence and increase of antimicrobial resistance (AMR) in the world. Enforcing the dispensing of antibiotics with prescription is a way to promote the rational use of antibiotics and preventing the development and spread of AMR. The pharmacist has the responsibility to supervise the dispensing of antibiotics in pharmacies and ensure its rational use. This study assessed pharmacists’ knowledge, attitude and practice regarding the dispensing of antibiotics without prescription in Tanzania.
Methods:
An online semi-structured questionnaire was designed, tested and shared with licensed pharmacists in Tanzania through an invitation link sent in their official WhatsApp groups. An SMS alternative was used contact list from the Pharmacy Council to administer the questionnaire, to pharmacist not subscribed on WhatsApp. Study data were collected and managed using REDCap electronic data capture tools hosted at Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. Data were then downloaded and exported into Statistical Package for Social Sciences (SPSS) version 20 for data analysis; Chi-square test was used to test association for categorical data, where a p-value of less than 0.05 was considered statistically significant.
Results:
More than 75% of pharmacists had excellent knowledge about the legal requirements for dispensing antibiotics and of the AMR challenge. Of the interviewed pharmacists, seventy-four percent admitted to dispensing antibiotics without prescription in their daily practice. Notably, 85.7% of pharmacists with high education were more likely to dispense without prescription compared to 69.9% among bachelor holders (p-value = 0.028). The main reasons for administering antibiotics without prescription were the profitability nature of pharmacy business, a failure of the patient to get a prescription and lack of stringent regulatory authorities. Penicillins, macrolides and fluoroquinolones were the classes of antibiotics mostly dispensed without a prescription.
Conclusion:
Even though pharmacists seem knowledgeable about AMR, they still dispense antibiotics without prescription in Tanzania. The regulatory authorities should make regular inspections in pharmacies to detect this malpractice. The community should be trained on the importance of taking laboratory tests before getting medications for their sickness by a qualified medical practitioner.