bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRUKTUR UKURAN DAN PARAMETER POPULASI HIU MONYET (Alopias superciliosus Lowe, 1839) DI PERAIRAN SAMUDERA HINDIA SELATAN JAWA
Authors: Chodrijah Umi , Prihatiningsih Prihatiningsih , Panggabean Anthony Sisco , Herlisman Herlisman 
Published: March 2020

Alopias superciliosus atau Bigeye Thresher Shark atau hiu monyet merupakan spesies yang bermigrasi sangat tinggi, bersifat oseanik dan hampir selalu ditemukan di laut tropis dan beriklim sedang. Spesies ini memiliki fekunditas yang rendah dan tingkat kenaikan populasi yang sangat rendah dibandingkan dengan hiu “Thresher” lainnya. Spesies ini sangat rentan terhadap eksploitasi penangkapan baik sebagai target maupun hasil tangkapan sampingan. Penelitian dilakukan pada bulan Mei 2015 sampai November 2016 di tempat pendaratan Pelabuhan Perikanan Samudera Cilacap. Penelitian ini bertujuan untuk mendapatkan struktur ukuran dan parameter populasi sebagai landasan untuk mengetahui status stok pada tingkat pemanfaatan terkini. Metode penelitian yang digunakan melalui pengamatan dan pengumpulan data oleh enumerator. Hiu monyet sebanyak 1437 individu merupakan hasil tangkapan pancing rawai yang tertangkap di Samudera Hindia Selatan Jawa. Hasil penelitian menunjukkan bahwa struktur ukuran hiu monyet (Alopias superciliosus) di perairan Samudera Hindia Selatan Jawa yang didaratkan di Cilacap berkisar antara 50-240 cm FL dengan modus berkisar antara ukuran 150 cmFL. Hubungan panjang berat hiu monyet jantan menunjukkan pertumbuhan bersifat isometrik (b=3) sedangkan hiu monyet betina bersifat allometrik positif (b>3). Perbandingan jenis kelamin hiu monyet jantan dan betina mendekati seimbang (0,97 : 1). Persamaan kurva pertumbuhan Von Bertalanffy untuk hiu monyet sebagai 𝐿(𝑡) = 270(1−𝑒^(−0,2(𝑡+0,01665)). Parameter mortalitas untuk hiu monyet, meliputi laju kematian total (Z), laju kematian alamiah (M) dan laju kematian karena penangkapan (F), masing-masing sebesar 0,85/tahun, 0,35/tahun dan 0,50/tahun. Laju eksploitasi (E) hiu monyet sebesar 0,59/tahun. Dengan demikian tingkat pemanfaatan hiu monyet sudah pada tingkat over fishing.
ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function
Authors: Matsuda Jun , Maier Mirela , Aoudjit Lamine , Baldwin Cindy , Takano Tomoko 
Published: March 2020

Significance Statement
Dysregulation of Cdc42 and other members of the Rho family of small GTPases in podocytes contributes to the pathogenesis of proteinuria. However, the upstream regulatory mechanisms for Cdc42 activity in podocytes are largely unknown. The authors identified ARHGEF7 (commonly known as β-PIX) as a predominant guanine nucleotide exchange factor and activator of Cdc42 in podocytes. They also demonstrated that β-PIX is required for the maintenance of podocyte architecture and glomerular function via Cdc42 and its downstream effects on Yes-associated protein (YAP) activity. Elucidating the precise details of how numerous regulatory proteins maintain the delicate balance of Rho GTPases in podocytes will be essential in understanding the pathogenesis of proteinuric glomerular diseases and identifying therapeutic targets.

Background
Previous studies showed that Cdc42, a member of the prototypical Rho family of small GTPases and a regulator of the actin cytoskeleton, is critical for the normal development and health of podocytes. However, upstream regulatory mechanisms for Cdc42 activity in podocytes are largely unknown.

Methods
We used a proximity-based ligation assay, BioID, to identify guanine nucleotide exchange factors that activate Cdc42 in immortalized human podocytes. We generated podocyte-specific ARHGEF7 (commonly known as β-PIX) knockout mice by crossing β-PIX floxed mice with Podocin-Cre mice. Using shRNA, we established cultured mouse podocytes with β-PIX knockdown and their controls.

Results
We identified β-PIX as a predominant guanine nucleotide exchange factor that interacts with Cdc42 in human podocytes. Podocyte-specific β-PIX knockout mice developed progressive proteinuria and kidney failure with global or segmental glomerulosclerosis in adulthood. Glomerular podocyte density gradually decreased in podocyte-specific β-PIX knockout mice, indicating podocyte loss. Compared with controls, glomeruli from podocyte-specific β-PIX knockout mice and cultured mouse podocytes with β-PIX knockdown exhibited significant reduction in Cdc42 activity. Loss of β-PIX promoted podocyte apoptosis, which was mediated by the reduced activity of the prosurvival transcriptional regulator Yes-associated protein.

Conclusions
These findings indicate that β-PIX is required for the maintenance of podocyte architecture and glomerular function via Cdc42 and its downstream Yes-associated protein activities. This appears to be the first evidence that a Rho–guanine nucleotide exchange factor plays a critical role in podocytes.
Comparative assessment of the short-term and long-term results of traditional and original ways of terminoterminal pancreatojejunostomy at a subtotal resection of a head of a pancreas
Authors: Propp A. R. , Degovtsov E. N. , Nikulina S. A. 
Published: March 2020

Aim. Compare the short-term and long-term results of the traditional and original methods of terminoterminal pancreaticojejunostomy with subtotal resection of the pancreatic head.Materials and methods. The results of subtotal resection of the pancreatic head in 20 patients with chronic pancreatitis with pancreatic duct obstruction at the level of the head are analyzed. In 10 cases at the final stage of the operation, the traditional terminoterminal pancreaticojejunostomy was performed, in 10 – in the original way.Results. Biliary tract decompression was performed in 65% of patients. The average duration of operation from original terminoterminal pancreaticojejunostomy operation was 170 min. [165; 180], intraoperative blood loss – 210 ml [200; 240], the average duration of postoperative hospital stay – 16 days [14; 17]; there were no mortality. After 5 years, in all patients who underwent the original terminoterminal pancreaticojejunostomy, the expressiveness of pain according to the developed ten-point scale was <4 points. Frequency for the first time diagnosed diabetes was 50–60%. The need for enzyme drugs was noted in 37.5–40% of cases. The frequency of complications requiring repeated surgical interventions is 12%, persistent disability – 50%. The quality of life indicators for Medical Outcome Study Short Form-36 and European Organisation for Research and Treatment of Cancer quality of life questionnaire – C30 exceeded those of the traditional method of completing the surgery by 3.9–8.4% and 9.3–16.7%.Conclusion. The original way of a single-row terminoterminal pancreaticojejunostomy with subtotal resection of the pancreatic head allows to reduce averages operative time and postoperative hospital stay. The risk of hemorrhagic complications from the resected pancreatic head does not decrease (10%). After 5 years, an insignificant advantage of the original method of terminoterminal pancreaticojejunostomy compared with the traditional one was noted. The incidence of permanent disability was 15% less, the quality of life indicators for the Medical Outcome Study Short Form-36 and European Organisation for Research and Treatment of Cancer quality of life questionnaire – C30 were better.
New in the problem gallstone bowel obstruction
Authors: Mamchich V. I. , Bondarenko N. D. , Chaika M. A. 
Published: March 2020

Aim. To identify the frequency of gallstone ileus based on the surgical experience of the Kiev region in patients with acute calculous cholecystitis and acute intestinal obstruction. To evaluate the capabilities of the gallstone ileus diagnosis algorithm for correct topical diagnosis before surgery.Materials and methods. For 2004–2018, 13713 patients with acute cholecystitis and 3609 patients with acute intestinal obstruction were hospitalized. In 0.64% of cases, gallstone ileus was diagnosed in patients with acute calculous cholecystitis, in 0.41% in choledocholithiasis, and in 2.4% in its complex forms. In 0.73% gallstone ileus was detected during operations for acute intestinal obstruction and in 1.12% for its obstructive form.Results. A total of 25 patients with gallstone intestinal obstruction underwent surgery. In the topical diagnosis of gallstone intestinal obstruction, X-ray contrast methods dominate. During surgical procedure, only with pyloroduodenal variants of obstruction, cholecystectomy is performed simultaneously with the elimination of obstruction. In other situations, cholecystectomy is performed after 3–8 months. Of the 25 patients, 4 patients died due to ascending cholangitis, peritonitis due to bile leakage, and severe co-morbidities.Conclusion. The use of the algorithm of advanced diagnostic methods allows you to receive a diagnosis in most patients. The most valuable in topical diagnostics are contrast methods. New in gallstone ileus is the migration of gallstone after endoscopic papillosphincterotomy with mechanical lithotripsy for choledocholithiasis, especially with its complex forms. In our opinion, all types of gallstone ileus can be combined into Bartolin-Bouveret syndrome, which first described this variant of mechanical intestinal obstruction.
Endoscopic hemostasis with self-expanding nitinol stents (literature review)
Authors: Anisimov A. Y. , Loginov A. V. , Ibragimov R. A. , Anisimov A. A. 
Published: March 2020

Aim. A critical analysis of modern scientific publications on the application in complex treatment program of patients with acute bleeding from esophageal varices endoscopic hemostasis with self-expanding nitinol Danish stents.Methods. Literature data are presented on the results of treating patients at the height of esophageal bleeding or with a high risk of recurrence by installing self-expanding nitinol Danish stents.Results. The advantages of Danish stent include low trauma; good tolerance; physiological saliva drainage and the possibility of receiving fluid and food through the mouth; repeated endoscopic examination of the esophagus and stomach after the introduction of the stent; reducing the risk of aspiration pneumonia; the impossibility of removal or displacement by the patient in a state of excitement. The disadvantages of self-expanding nitinol Danish stents, in addition to the risk of migration from the esophagus to the stomach with loss of its plugging function, include the limitation of the therapeutic effect only to varicose veins of the esophagus, the development of small erosions or ulcers on the mucous membrane of the esophagus after stent removal.Conclusion. The extent to which endoscopic hemostasis with self-expanding nitinol Danish stents will take a strong place in the treatment of patients with variceal bleeding is not clear. In the recommendations of the Baveno VI Consensus the method is considered as an attractive alternative to Sengstaken–Blackmore balloon tamponade, however, the need for confirmation of the initial clinical results by further comparative randomized controlled trials is indicated.
TEVHİD-İ TEDRİSAT KANUNUNUN AMAÇ GERÇEKLEŞTİRME BAŞARISINA DAİR BİR İNCELEME
Authors: AKGÜNDÜZ Hasan 
Published: March 2020

Bu
makalede, Tevhid-i Tedrisat Kanunu ile başlayan ve yüzyılını doldurma eşiğinde
bulunan Cumhuriyetin Eğitim Devrimi, amaç gerçekleştirme başarısı bakımından
literatür ve belgeler desteğinde kuramsal/tarihsel bakış yöntemiyle irdelenmiş
ve değerlendirilmiştir. Vaki değerlendirme sonucu konu hakkında erişilen kritik
bulgular; hukuki referansı Tevhid-i Tedrisat Kanunu, kök değerleri ise Millilik
ve Laiklik olan eğitim devriminin, gelinen durum itibariyle farklı sosyal hayat
alanlarına hitap eden cumhuriyet devrimleri arasında amaç gerçekleştirme
başarısı en sınırlı kalan devrimsel girişim olduğu, bahse konu neticenin beşeri
fenomenlerde tarih bilinci eşliğinde öznel nadas yöntemiyle sağlanan
gelenek-yenilik kutupsal sinerjisi üzerinden dikey mutasyon-aşkınlık-devrimsel
büyüme kanuniyetine aykırı bir yola girilmiş olması, bu meyanda millilik ve
laiklik değerlerinin sürecin başında buharlaşmasıyla oluşan tepkisel iklimde
baskılanmış köklerin toprak altında vahşileşerek toprak üstü oluşumları bloke
etmiş olması, kökten beslenerek kökleri üzerinde büyüyemediği için hırpalanmış
durumdaki formal sistemin mevcudiyet eksikliğinde ise gelenekçi teist
fırsatçıların millilik, pragmatist-ateist fırsatçıların da laiklik damarını
istismar ederek gölge sistem halinde devreye girmesiyle ilişkili olduğudur.
Gerçekten de hem yaşam enerjisi tükenmiş gölge medrese-tekke modelinin hala itibar
görmesi ve halktan güç devşirmeye devam eden korsan yıkıcı gidişatı, hem de
anlam paralizasyonuyla malül aynı tepkisel iklimde diğer rövanşist fırsatçılara
yönelen teveccüh, insanların formal sistemle tinsel meşruiyetten yoksun
mesafeli ilişkisi ve doğanın boşluk kaldırmaması nedeniyle insan/eğitim
tefecilerinin merdiven altı korsan çözümlerine tepkisel akışından öte bir anlam
ifade etmemektedir.&nbsp;
Targeted High-Resolution Structure from Motion Observations over the Mw 6.4 and 7.1 Ruptures of the Ridgecrest Earthquake Sequence
Authors: Donnellan Andrea , Lyzenga Gregory , Ansar Adnan , Goulet Christine , Wang Jun , Pierce Marlon 
Published: March 2020

AbstractWe carried out six targeted structure from motion surveys using small uninhabited aerial systems over the Mw 6.4 and 7.1 ruptures of the Ridgecrest earthquake sequence in the first three months after the events. The surveys cover approximately 500 × 500 m areas just south of Highway 178 with an average ground sample distance of 1.5 cm. The first survey took place five days after the Mw 6.4 foreshock on 9 July 2019. The final survey took place on 27 September 2019. The time between surveys increased over time, with the first five surveys taking place in the first month after the earthquake. Comparison of imagery from before and after the Mw 7.1 earthquake shows variation in slip on the main rupture and a small amount of distributed slip across the scene. Cracks can be observed and mapped in the high-resolution imagery, which show en echelon cracking, fault splays, and a northeast-striking conjugate fault at the Mw 7.1 rupture south of Highway 178 and near the dirt road. Initial postseismic results show little fault afterslip, but possible subsidence in the first 7–10 days after the earthquake, followed by uplift.
Seismological Observatory Software: 30 Yr of SEISAN
Authors: Havskov Jens , Voss Peter H. , Ottemöller Lars 
Published: March 2020

AbstractThe SEISAN software package for processing of earthquake data has been in use for 30 yr. SEISAN is a collection of programs that help to carry out tasks from the basic processing at a seismological observatory to more advanced seismological research. During its history, the software has been adopted to different hardware and operating systems. However, the core of the software with a folder- and files-based database and event-based processing has remained stable. The main focus in the design and development of the software has been the efficiency in data processing for the user. The software comes with manual, tutorial, and training exercises. This together with regular training activities has made SEISAN a useful tool for many observatories around the world.
ECG signals filtering and analysis using the Compact Genetic Algorithm Based on Abstract Data Types in GPU/CUDA
Authors: Maciel 1 A. , Vieira 2 R. V. 
Published: March 2020

This paper presents the process of adaptive filtering of cardiovascular disease signals from the processing and cleaning of ECG signals developed by the Compact Genetic Algorithm Based on Abstract Data Types (CGAADT), implemented in MATLAB using GPU/CUDA architecture from the examples of the base of MIT-BIH data. The results show that CGAADT can improve the filtering, cleaning, detection and diagnosis of arrhythmias using a single algorithm (CGAADT) in the adoption of a representation for the population with fixed size of chromosomes, pre-established by fragmentation of the GPU base when implemented in high performance systems, aiming to improve the health systems offered to patients with cardiovascular problems.
Rough Approximation Operators in a Topological Ring
Authors: OĞUZ Gülay 
Published: March 2020

The goal of this article is to examine
the concept of topological ring from the perspective of the rough set theory
and to introduce the approximation
operators in a topological ring with respect to its ideal. Moreover, the
definitions of lower topological rough subring and upper topological rough
subring are presented. After that, the notion of topological rough ring is
described and some related properties are studied.
Le phénotypage de l’efficacité alimentaire et de ses composantes, une nécessité pour accroître l’efficience des productions animales
Authors: PHOCAS F. , AGABRIEL J. , DUPONT-NIVET M. , GEURDEN J. , MÉDALE F. , MIGNON-GRASTEAU S. , GILBERT H. , DOURMAD J.Y. 
Published: March 2020

Dans un contexte de demande croissante en protéines animales, l’élevage de précision et la sélection animale doivent viser à accroître la compétitivité des systèmes de production et à réduire leur impact environnemental. Les animaux doivent être plus efficaces pour transformer leur ration (réduire l’ingéré tout en maintenant une production stable), en acceptant des ressources alimentaires variées (protéines ou fibres) et en minimisant leurs rejets (totaux ou leurs composantes N et P, GES). Toutefois, l’efficacité alimentaire est un phénotype complexe qui doit être phénotypé finement pour comprendre les processus biologiques sous-jacents avant d’identifier les leviers d’action pour l’améliorer (efficacité digestive vs métabolique ; efficacité énergétique vs protéique). Ce phénotypage doit être réalisé en conditions variées tant sur le plan du génotype, du niveau alimentaire que de la composition de la ration (teneur en fibres, en acides aminés). Il s’agit aussi d’envisager une approche prédictive de l’ingéré et de l’efficacité alimentaire basée sur des paramètres peu coûteux et faciles à mesurer (croissance, bio-marqueurs…) dans le cadre d’un élevage de précision ou de programmes de sélection génétique, car le phénotypage à large échelle de l’ingéré reste coûteux et parfois difficile à mettre en oeuvre. Pour évaluer l’efficience globale des systèmes de productions animales, il s’agit de considérer les réponses des animaux pour des génotypes et des régimes alimentaires contrastés en termes d’efficacité alimentaire et de rejets en quantité et en qualité (GES, N, P), mais aussi de robustesse des animaux (comportement alimentaire, activité générale, santé).
Implementation of Procedure-Specific Opioid Guidelines
Authors: Wyles Cody C. , Hevesi Mario , Ubl Daniel S. , Habermann Elizabeth B. , Gazelka Halena M. , Trousdale Robert T. , Turner Norman S. , Pagnano Mark W. , Mabry Tad M. 
Published: March 2020

Background:
Evidence-based, procedure-specific guidelines for prescribing opioids are urgently needed to optimize pain relief while minimizing excessive opioid prescribing and potential opioid diversion in our communities. A multidisciplinary panel at our institution recently developed procedure-specific guidelines for discharge opioid prescriptions for common orthopaedic surgical procedures. The purpose of this study was to evaluate postoperative opioid prescription quantities, variability, and 30-day refill rates before and after implementation of the guidelines.

Methods:
This retrospective cohort study was conducted at a single academic institution from December 2016 to March 2018. Guidelines were implemented on August 1, 2017, with a recommended maximum opioid prescription quantity for 14 common orthopaedic procedures. Patients who underwent these 14 procedures during the period of December 2016 to May 2017 made up the pre-guideline cohort (n = 2,223), and patients who underwent these procedures from October 2017 to March 2018 made up the post-guideline cohort (n = 2,300). Opioid prescription quantities were reported as oral morphine equivalents (OME), with medians and interquartile ranges (IQRs). Four levels were established for recommended prescription maximums, ranging from 100 to 400 OME.

Results:
In the pre-guideline cohort, the median amount of prescribed opioids across all procedures was 600 OME (IQR, 390 to 863 OME), which decreased by 38% in the post-guideline period, to a median of 375 OME (IQR, 239 to 400 OME) in the post-guideline cohort (p < 0.001). The 30-day refill rate did not change significantly, from a rate of 24% in the pre-guideline cohort to 25% in the post-guideline cohort (p = 0.43). Multivariable analysis demonstrated that guideline implementation was the factor most strongly associated with prescriptions exceeding guideline maximums (odds ratio [OR] = 9.9; p < 0.001). Age groups of <80 years (OR = 2.0 to 2.4; p < 0.001) and males (OR = 1.2; p = 0.025) were also shown to have higher odds of exceeding guideline maximums.

Conclusions:
Procedure-specific guidelines are capable of substantially decreasing opioid prescription amounts and variability. Furthermore, the absence of change in refill rates suggests that pain control remains similar to pre-guideline prescribing practices. Evidence-based guidelines are a readily employable solution that can drive rapid change in practice and enhance the ability of orthopaedic surgeons to provide responsible pain management.
New, Minimally Invasive, Anteromedial-Distal Approach for Plate Osteosynthesis of Distal-Third Humeral Shaft Fractures
Authors: Cañada-Oya Hermenegildo , Cañada-Oya Sabina , Zarzuela-Jiménez Cristina , Delgado-Martinez Alberto D. 
Published: March 2020

Background:
Fractures of the distal third of the humeral shaft remain a challenge today. Plate osteosynthesis is the most commonly used method of treatment. Current minimally invasive plate osteosynthesis (MIPO) techniques applied to the distal part of the humerus have shown a high risk of radial nerve injury, and they are unable to adequately fix distal-most fractures. Our hypothesis was that using a new MIPO approach, distal humeral shaft fractures can be safely fixed. The aim of this study was to develop this new anteromedial-distal MIPO approach.

Methods:
We conducted a laboratory descriptive study using 16 arms from adult human specimens. A new anteromedial-distal MIPO approach, starting distally through a small window in the pronator teres muscle, was developed. A premolded plate was introduced in the anterior side of the medial epicondylar area, through the anterior face of the humerus, up to the proximal part of the humeral shaft. Several anatomical parameters were measured on dissection to define the distances of the plate and screws to the neurovascular structures that could be at risk.

Results:
The radial nerve was not at risk because of its pathway through the posterior and lateral aspects of the arm. The mean distance from the most distal border of the medial epicondyle to the proximal border of the coronoid fossa was 3.36 cm (95% confidence interval [CI], 3.23 to 3.50 cm). At least 3 screws could be inserted in all specimens in this area and up to 5 when the fixation area was extended 2 cm proximally. The mean width of the medial epicondylar area was 2.19 cm (95% CI, 2.03 to 2.33 cm), space enough for the distal fixation of the plate. The ulnar nerve was at risk only from the tip of the most distal screw (mean distance of 2.50 mm; 95% CI, 1.60 to 3.40 mm) in specimens with a very narrow medial epicondylar area.

Conclusions:
This approach provides adequate fixation for distal humeral shaft fractures, but proper clinical studies must be undertaken.

Clinical Relevance:
This new approach avoids the risk of radial nerve injury.