bluuebunny/crossref_metadata_2025_split huggingface dataset:
R-MPV Followed by High-dose Chemotherapy With Thiotepa-based and Autologous Stem Cell Transplantation for Newly Diagnosed Primary Central Nervous System Lymphoma: A Single-center Experience
Authors: Lee Ji Yun , Paik Jin Ho , Suh Koung Jin , Kim Ji-Won , Kim Se Hyun , Kim Jin Won , Kim Yu Jung , Lee Keun-Wook , Kim Jee Hyun , Bang Soo-Mee , Lee Jong-Seok , Lee Jeong-Ok 
Published: October 2020

Abstract
BackgroundHigh-dose chemotherapy followed by autologous stem-cell transplantation (HDC–ASCT) as a consolidation treatment is a promising approach in eligible patients with newly diagnosed primary central nervous system lymphoma (PCNSL). This study sought to assess the safety and efficacy of initial methotrexate-based chemotherapy followed by consolidation HDC-ASCT with a thiotepa-based conditioning regimen in patients with newly diagnosed PCNSL. MethodsIn this retrospective analysis, 22 patients with newly diagnosed PCNSL received chemotherapy with rituximab, methotrexate, procarbazine, and vincristine (R-MPV). Those who showed a complete or partial response subsequently received consolidation HDC-ASCT with a thiotepa-based conditioning regimen and no radiotherapy. ResultsCharacteristics of the PCNSL patients included a median age of 57 years (range: 49–67 years), Eastern Cooperative Oncology Group performance status of grade 2 or more in 9.1%, elevated lactate dehydrogenase level in 26.3%, and involvement of multiple lesions in 72.1%. About 82% of patients received six cycles of induction chemotherapy, which was well-tolerated with excellent disease control. The rate of confirmed/or unconfirmed complete response increased from 45.5% in the interim to 81.8% before HDC-ASCT. With a median follow-up of 19.6 months (range: 7.5–56.5 months), the 2-year progression-free survival and overall survival estimates were 84% and 88%, respectively. There were no treatment-related deaths. Grade 3 toxicity was recorded in 90.9% after HDC-ASCT, and the most common grade 3 adverse event was febrile neutropenia without sepsis. ConclusionsThe discussed treatment approach appears feasible in patients with newly diagnosed PCNSL, yielding encouraging results.
Ultrahigh water permeation with high multivalent metal ions rejection rate through graphene oxide membranes
Authors: Dai Fangfang , Zhou Feng , Chen Junlang , Liang Shanshan , Chen Liang , Fang Haiping 
Published: October 2020

Abstract
Graphene oxide (GO) membranes show exceptional molecular permeation properties and have gained tremendous attention in the area of wastewater treatment. However, they still suffer from some limitations, such as low water permeance when the ion rejection rate is at a satisfactory level and unstable performance. Here, we develop a sort of GO membrane that exhibits ultrahigh water permeance up to 75.2 L m−2 h−1 bar−1 while still maintaining a high rejection rate of 99.9% for multivalent metal ions. Importantly, of all state-of-the-art nanofiltration membranes, this is the most permeable membrane with a satisfactory level of rejection rate for multivalent ions. Furthermore, the GO membrane has outstanding stability over long-time operation. Our work provides a simple way to fabricate GO membranes with outstanding water purification performance.
Spinon Fermi surface spin liquid in a triangular lattice antiferromagnet NaYbSe2
Authors: Dai Peng-Ling , Zhang Gaoning , Xie Yaofeng , Duan Chunruo , Gao Yonghao , Zhu Zihao , Feng Erxi , Huang Chien-Lung , Cao Huibo , Podlesnyak A. , Granroth Garrett , Everett S. , Neuefeind Joerg , Voneshen David , Wang Shun , Tan Guotai , Morosan Emilia , Wang Xia , Shu Lei , Chen Gang , Guo Yanfeng , Lu Xingye , Dai Pengcheng 
Published: October 2020

Abstract
Triangular lattice of rare-earth ions with interacting effective spin-1/2 local moments is an ideal platform to explore the physics of quantum spin liquids (QSLs) in the presence of strong spin-orbit coupling, crystal electric ﬁelds, and geometrical frustration. The Yb delafossites, NaYbCh2 (Ch=O, S, Se) with Yb ions forming a perfect triangular lattice, have been suggested to be candidates for QSLs. Previous thermodynamics, nuclear magnetic resonance, and powder sample neutron scattering measurements on NaYbCh2 have supported the suggestion of the QSL ground states. The key signature of a QSL, the spin excitation continuum, arising from the spin quantum number fractionalization, has not been observed. Here we perform both elastic and inelastic neutron scattering measurements as well as detailed thermodynamic measurements on high-quality single crystalline NaYbSe2 samples to conﬁrm the absence of long-range magnetic order down to 40 mK, and further reveal a clear signature of magnetic excitation continuum extending from 0.1 to 2.5 meV. By comparing the structure of our magnetic excitation spectra with the theoretical expectation from the spinon continuum, we conclude that the ground state of NaYbSe2 is a QSL with a spinon Fermi surface.
Tumor Mutation Burden: A Predictive Biomarker for Gastric Cancer Immunotherapy
Authors: Xiang Renshen , Fu Tao 
Published: October 2020

Abstract
Background: Few studies have focused on the underlying relationship between the prognosis of tumor mutation burden (TMB) and immune cell infiltration in gastric cancer (GC). This study aims to explore the relationship among TMB and various components in tumor microenvironment (TME). Methods: The transcription profiles and somatic mutation data of 375 tumor and 32 normal samples were obtained from TCGA. The specific mutation information was summarized and visualized with waterfall chart, then number of TMB per million bases of each GC sample was calculated. Immune/stromal scores and tumor purity were calculated by the ‘ESTIMATE’ package, and the fractions of 22 immune cells in each sample were evaluated by CIBERSORT algorithm. Finally, Lass regression analysis was utilized to generate a prognostic scoring signature with TCGA cohort as the training set, while GES84437 cohort as the validation set. Results: Higher TMB indicated favorable overall survival (OS, P = 0.043)，better disease specific survival (P = 0.029), and longer progression free interval (P = 0.004). TMB was positively correlated with MSI and tumor purity, while negatively associated with immune/stromal scores. Moreover, TMBhigh group has lower T cells CD4 memory resting (P < 0.001) and T cells regulatory (P < 0.001), and more T cells CD4 memory activated (P < 0.001) and T cells follicular helper (P = 0.009). More importanly, the infiltration of dendritic cells activated predicted a worse OS, while T cells CD4 memory activated and T cells follicular helper meant a better OS. Finally, a nomogram combined TMB-related signature with clinicopathologic variables can successfully predict the OS with high accuracy and efficiency.Conclusion: TMB can effectively reveal the immune infiltration status in TME of GC, and might serve as a prognostic classifier for individualized treatment of clinical decision-making.
Molecular Characterization of Cytidine Monophospho-N-Acetylneuraminic Acid Hydroxylase (CMAH) Gene and Frequency of Blood Types in Stray Cats of İzmir, Turkey
Authors: Can Hüseyin , Alak Sedef Erkunt , Köseoğlu Ahmet Efe , Şahar Umut , Bostanbaş Berna , Baydarlı Serdar , Döşkaya Mert , ÜN Cemal 
Published: October 2020

Abstract
Cytidine monophospho-n-acetylneuraminic acid hydroxylase (CMAH) gene associated with blood groups in cats encodes CMAH enzyme that converts Neu5Ac to Neu5Gc. Although variations in CMAH gene of pedigree cats have been revealed, the presence/lack of them in non-pedigree stray cats is unknown. Therefore, the present study aimed to investigate the variations in CMAH gene and the quantity of Neu5Ac and Neu5Gc on erythrocytes of non-pedigree stray cats (n:12) living in İzmir, Turkey. Meanwhile, these 12 cats were typed using the mitochondrial DNA control region. Also, the frequency of blood types was determined in 76 stray cats including 12 cats that were used for CMAH and Neu5A/Neu5Gc analysis. In total, 14 SNPs were detected in 5’UTR as well as in exon 2, 4, 9, 10, 11 and 12 of CMAH gene. Among these SNPs, -495C>T in 5’UTR was detected for the first time as heterozygous in type A and AB cats, and homozygous and heterozygous in type B cats. The remaining 13 that have been detected in previous studies were also found as homozygous or heterozygous. Homozygous form (T/T) of the -495C>T polymorphism was found among only type B cats. Among the polymorphisms previously determined in the literature, homozygous form of the -371C>T polymorphism was found among only type B cats whereas heterozygous form (A/C) of the 327A>C polymorphism was detected in only type AB cats. Both Neu5Gc and Neu5Ac were detected in type A and AB cats. In type B cats, only Neu5Ac was detected. Among two type AB cats, the level of Neu5Ac was found higher in cat carrying heterozygous form (T/C) of 1392T>C. Mitotypes A, A6, D, E and 1 were detected among stray cats analysed for the characterisation of CMAH gene. The prevalence of type B cats (67.1%) was higher than others. As a result, the presence of a new SNP as well as previous SNPs indicates that more variations can be found in stray cats with a more comprehensive study in the future. Also, the high prevalence of type B cats demonstrates the high risk of neonatal isoerythrolysis among stray cats living in İzmir, Turkey.
Design and Evaluation of the I-SCAN Faculty POCUS Program
Authors: Janjigian Michael , Dembitzer Anne , Srisarajivakul-Kl Caroline , Hardower Khemraj , Cooke Deborah , Zabar Sondra , Sauthoff Harald 
Published: October 2020

Abstract
IntroductionPoint-of-care ultrasound (POCUS) is becoming widely adopted with increasing accessibility of courses. Little is known about the optimal design of the introductory course or longitudinal training programs that are critical to success.AimTo evaluate the effectiveness of a comprehensive hospitalist POCUS training programSettingFour hospitals at an academic medical center.Program DescriptionThe program consisted of a 2-day introductory course and a longitudinal phase comprising clinical POCUS practice, clip uploading with online feedback, hands-on teaching, and monthly ultrasound conferences. Assessments were performed immediately before and after the 2-day course and after one year.Program EvaluationKnowledge increased from baseline to post 2-day (median score 58% and 85%, respectively, p<0.001) and decreased slightly at one year (median score 81%, p=0.012). After the 2-day introductory course, the median score for hands-on image acquisition skills, the principal metric of learner success, was 75%. After one year, scores were similar (median score 74%). Confidence increased from baseline to post 2-day (1.5 to 3.1 on a 4 point Likert scale from Not at all confident (1) to Very confident (4), p<0.001), and remained unchanged after one year (2.73). Course elements correlating with a passing score on the final hands-on test included number of clip uploads (r=0.85, p,0.001), attendance at hands-on sessions (r=0.7, p=0.001), and attendance at monthly conferences (r=0.50, p=0.03).DiscussionThe I-ScaN POCUS training program increased hospitalist knowledge, skill and confidence with maintained skill and confidence after one year. Uploading clips and attending hands-on teaching sessions were most correlative with learner success.
Increasing uptake of colon cancer screening in a medically underserved population with the addition of blood-based testing
Authors: Ioannou Stephanie , Sutherland Kyle , Sussman Daniel A. , Deshpande Amar R. 
Published: October 2020

Abstract
Adherence to colorectal cancer screening is suboptimal, particularly in medically underserved populations. We report here on our assessment of the impact of offering a blood-based screening test on screening rates in a health fair setting. Patients attending student-run health fairs who met colon cancer screening guideline eligibility criteria received a recommendation to attend that screening station. Patients were offered recommended accepted screening methods, and if they declined they were offered blood-based testing. Screening rates, test outcomes, and the rate of follow up completion of colonoscopy were measured and compared with historic screening outcomes. Of 1401 screening eligible patients, 640 (45.7%) attended the colon cancer screening station, of whom 460 were eligible for assessment. Amongst these, none selected colonoscopy, 30 (6.5%) selected FIT, and 430 (93.5%) selected blood-based testing. Only 2 patients returned the FIT. For the blood test, 88 were positive, and 20 of these received a follow up colonoscopy. Based on this assessment, blood-based testing is an effective method to increase screening rates in medically underserved populations, though efforts to further improve access to follow up colonoscopy are necessary.
Comparative Transcriptomics Provides Insight Into Rind Color Polymorphism in Watermelon
Authors: Liu Dongming , Yang Huihui , Sun Dongling , Zhang Minjuan , Dou Junling , Yang Sen , Zhu Huayu , Hu Jianbin , Sun Shouru , Yang Luming 
Published: October 2020

Abstract
BackgroundAs an important agronomic trait affecting breeding and consumption choice, rind color of watermelon [Citrullus lanatus (Thunb.) Matsum. and Nakai] receives considerable attention from breeders. Although rind color occupies an important place in watermelon breeding work, the underlying molecular mechanism governing this complex trait has still not been determined. ResultsIn the present study, chlorophyll and carotenoid contents were hypothesized to be the main factors determining rind color. Clearly different structures and numbers of chloroplasts and grana lamellae were found among materials with different rind colors. To study the genes involved in the coloration process of the yellow, dark green, light green, and light green-gray rinds, 84,516 unigenes were obtained from the rind transcriptome. Through DEGs screening and pathway analysis of chlorophyll and carotenoid mechanism, the genes with abnormal expression levels were identified. Then, the nucleotide sequences and expression levels of the putative genes responsible for different rind colors were studied.ConclusionsThis study provides a comprehensive insight on the factors affecting rind coloration and investigated expression levels of the critical genes concerning pigment metabolism in watermelon. These results would help to analyze the molecular mechanisms of rind coloration regulation and development of the related organelles.
Genome wide analysis of kinesin gene family in Citrullus lanatus reveals an essential role in early fruit development
Authors: Tian Shujuan , Jiang Jiao , Xu Guo-qi , Wang Tan , Liu Qiyan , Chen Xiner , Liu Man , Yuan Li 
Published: October 2020

Abstract
BackgroundKinesin (KIN) as a motor protein is a versatile nano-machine and involved in diverse essential processes in plant growth and development. However, the kinesin gene family has not been identified in watermelon, a valued and nutritious fruit, and yet their functions has not been characterized. Especially, their involvement in early fruit development, which directly determines the size, shape, yield and quality of the watermelon fruit, remains unclear.ResultsIn this study, we performed a whole-genome search and comprehensive analysis in C. lanatus. In total, 48 kinesins were identified and categorized into 10 kinesin subfamilies groups based on phylogenetic analysis. Their uneven distribution on 11 chromosomes was revealed by chromosomal distribution analysis. Conserved motif analysis showed that the ATP-binding motif of kinesins was conserved within all subfamilies, but not the microtubule-binding motif. 10 segmental duplication pairs genes were detected by the syntenic and phylogenetic approaches, which explains the expansion of the kinesin gene family in C. lanatus genome. Moreover, 5 ClKINs genes are specifically and abundantly expressed in early fruit developmental stages according to comprehensive expression profile analysis, indicating their critical regulatory roles during early fruit development. Our current data also demonstrated that the majority of kinesin genes were responsive to plant hormones, implying their involvement in the signaling pathways of plant hormones.ConclusionsThis study is the first comprehensive analysis of the kinesin gene family in watermelon, which establishes a foundation for further functional investigation of C. lanatus kinesin genes and provides novel insights into their biological functions. In addition, these results will provide a useful resource for further selecting an artificial regulator of fruit development in C. lanatus.
Analysis of Mental Health Status and Influencing Factors of Overseas Chinese in Laos
Authors: Li Yanfang , Tao Qin , Zhou Xiaoyu , Zhang Kan 
Published: October 2020

Abstract
Background: To provide a reference for foreign aid workers by identifying the mental health status of Overseas Chinese resident in Laos and the influencing factors. Methods :Convenience sampling method was used to select the 414 Overseas Chinese in Laos from April 10 to May 10 in 2020. The mental health status was assessed by using PHQ-9 and GAD-7 scales, and the influencing factors were analyzed. Results :The prevalence of anxiety and depression among overseas Chinese in Laos was 28.5% and 36.2%. Factors influencing anxiety and depression included family members' attitudes towards their departure abroad, financial aid subsidies, living standards in Laos, and Laotian food. Conclusion :Degrees of anxiety and depressive were varying among Overseas Chinese in Laos. Depression was highly correlated with anxiety, and the influencing factors of anxiety and depression were different. Foreign aid workers should pay attention to the mental health of the Overseas Chinese in Laos and the influencing factors.
Causes of Preterm and Low Birth Weight Neonatal Mortality in a Rural Community in Kenya: Evidence From Verbal and Social Autopsy
Authors: Olack Beatrice , Santos Nicole , Inziani Mary , Moshi Vincent , Oyoo Polycarp , Nalwa Grace , Ouma Linet , Otare Christopher , Walker Dilys , Otieno Phelgona Apondi 
Published: October 2020

Abstract
BackgroundUnder-five mortality in Kenya has declined over the past two decades. However, the reduction in the neonatal mortality rate has remained stagnant. In a country with weak civil registration and vital statistics systems, there is an evident gap in documentation of mortality and its causes among low birth weight (LBW) and preterm neonates. We aimed to establish causes of neonatal LBW and preterm mortality in Migori County, among participants of the PTBI-K (Preterm Birth Initiative-Kenya) study.MethodsThis was a cross sectional study whereby Verbal and social autopsy (VASA) interviews were conducted with caregivers of deceased LBW and preterm neonates delivered within selected 17 health facilities in Migori County, Kenya. The probable cause of death was assigned using the WHO International Classification of Diseases (ICD-10). ResultsBetween January 2017 to December 2018, 3175 babies were born preterm or LBW, and 162 (5.1%) died in the first 28 days of life in 17 participating health facilities in the PTBI-K project. VASA was conducted among 88 (53.7%) neonatal deaths. Almost half (38, 43.2%) of the deaths occurred within the first 24 hours of life. Birth asphyxia (45.5%), neonatal sepsis (26.1%), respiratory distress syndrome (12.5%) and hypothermia (11.0%) were the leading causes of death. In the early neonatal period, majority (54.3%) of the neonates succumbed to asphyxia while in the late neonatal period majority (66.7%) succumbed to sepsis. Delay in seeking medical care was reported for 4 (5.8%) of the neonatal deaths. ConclusionDeaths among LBW and preterm neonates occur early in life due to preventable causes. This calls for enhanced intrapartum and immediate postpartum care interventions targeting asphyxia, sepsis, respiratory distress syndrome and hypothermia.
Risk Factors for Workplace Encounters with Weapons by Hospital Employees
Authors: Blando James , Paul Chalsie , Szklo-Coxe Mariana 
Published: October 2020

Abstract
Background:Healthcare workers are at a high risk of experiencing workplace violence and associated injuries, and the presence of weapons in a healthcare setting increases the potential severity of injuries and consequences of violence. The specific aim of this study was to determine which organizational factors were associated with frequent weapons confiscation in a healthcare facility and to identify potential effective interventions. This study investigated the hypothesis that hospital-related factors impact the frequency of weapons confiscation.Methods:A cross-sectional survey was administered on-line to hospital security directors and assessed the associations of organizational factors with the frequency of weapons confiscation.Results: It was found that hospitals with metal detectors were more than 5 times as likely to frequently confiscate weapons, suggesting this intervention is effective. It was also found that hospitals with psychiatric units were more likely to have frequent confiscation of weapons, likely due to the standard procedure of searching patients before admission to the psychiatric unit. Several factors thought to be potentially related, such as perception of risk and state violent crime rates, were not associated with weapons confiscation risk. Conclusion: This data suggests that searching patients and using metal detectors are important tools in the prevention of weapons entering a healthcare setting. This reduction would likely enhance safety and reduce injury from workplace violence.
Common Mental Disorders in Mothers of Children Attending Out-patient Malnutrition Clinics in Rural North-western Nigeria: A Cross-sectional Study
Authors: Abdullahi Aminu Taura , Farouk Zubaida Ladan , Imam Abdulazeez 
Published: October 2020

Abstract
BackgroundChildren with uncomplicated severe acute malnutrition are managed routinely within out-patient malnutrition treatment programs. These programs do not offer maternal mental health support services, despite maternal mental health playing a significant role in the nutritional status of children. Additionally, the burden of maternal Common Mental Disorders (CMDs) is poorly described among mothers of children attending these programs. This study thus determined the burden and risk factors for maternal CMDs among children attending out-patient malnutrition clinics in rural North-western Nigeria.MethodsWe conducted a cross-sectional study among 204 mothers of children with severe acute malnutrition who attending eight out-patient malnutrition clinics in Jigawa, North-western Nigeria. We used the World Health Organization Self-Reporting Questionnaire-20 (WHO SRQ-20) screening tool, a recognised and validated proxy measure for CMDs to identify mothers with CMDs. The prevalence of maternal CMDs was determined by identifying the proportion of mothers with SRQ scores of ≥8. Risk factors for CMD were determined using multivariable logistic regression. ResultsMaternal CMD prevalence in children attending these facilities was high at 40.7%. Non-receipt of oral polio vaccine (OPV) (AOR 6.23, 95%CI 1.85 to 20.92) increased the odds for CMD. While spousal age above 40 (AOR 0.95, 95%CI 0.90 to 0.99) and long years spent married (AOR 0.92, 95%CI 0.85 to 0.98) decreased the odds for CMD. ConclusionsOur findings indicate maternal CMD burden is high in out-patient malnutrition clinics in North-western Nigeria. Maternal mental health services would need to be integrated into the community management of acute malnutrition programs to provide more holistic care, and possibly improve long-term outcomes after discharge from these programs