bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatotoxicity and Liver-Related Mortality in Women of Childbearing Potential Living With Human Immunodeficiency Virus and High CD4 Cell Counts Initiating Efavirenz-Containing Regimens
Authors: Bhattacharya Debika , Gupta Amita , Tierney Camlin , Huang Sharon , Peters Marion G , Chipato Tsungai , Martinson Frances , Mohtashemi Neaka , Dula Dingase , George Kathy , Chaktoura Nahida , Klingman Karin L , Gnanashanmugam Devasena , Currier Judith S , Fowler Mary G 
Published: March 2020

Abstract

Background
Severe hepatotoxicity in people with human immunodeficiency virus (HIV) receiving efavirenz (EFV) has been reported. We assessed the incidence and risk factors of hepatotoxicity in women of childbearing age initiating EFV-containing regimens.

Methods
In the Promoting Maternal and Infant Survival Everywhere (PROMISE) trial, ART-naive pregnant women with HIV and CD4 count ≥ 350 cells/μL and alanine aminotransferase ≤ 2.5 the upper limit of normal were randomized during the antepartum and postpartum periods to antiretroviral therapy (ART) strategies to assess HIV vertical transmission, safety, and maternal disease progression. Hepatotoxicity was defined per the Division of AIDS Toxicity Tables. Cox proportional hazards models were constructed with covariates including participant characteristics, ART regimens, and timing of EFV initiation.

Results
Among 3576 women, 2435 (68%) initiated EFV at a median 121.1 weeks post delivery. After EFV initiation, 2.5% (61/2435) had severe (grade 3 or higher) hepatotoxicity with an incidence of 2.3 (95% confidence interval [CI], 2.0–2.6) per 100 person-years. Events occurred between 1 and 132 weeks postpartum. Of those with severe hepatotoxicity, 8.2% (5/61) were symptomatic, and 3.3% (2/61) of those with severe hepatotoxicity died from EFV-related hepatotoxicity, 1 of whom was symptomatic. The incidence of liver-related mortality was 0.07 (95% CI, .06–.08) per 100 person-years. In multivariable analysis, older age was associated with severe hepatotoxicity (adjusted hazard ratio per 5 years, 1.35 [95% CI, 1.06–1.70]).

Conclusions
Severe hepatotoxicity after EFV initiation occurred in 2.5% of women and liver-related mortality occurred in 3% of those with severe hepatotoxicity. The occurrence of fatal events underscores the need for safer treatments for women of childbearing age.
Reoperative, transapical off-pump neochordae implantation for recurrent degenerative mitral regurgitation resulting from a newly ruptured native chord
Authors: Drasutiene Agne , Chitwood W Randolph , Rucinskas Kestutis , Aidietis Audrius 
Published: March 2020

Abstract
Transapical mitral valve repair with NeoChord implantation is effective and safe to replace ruptured chordae due to degenerative disease. Redo transapical neochordae implantation has never been reported in the literature. We present a case report of a 53-year-old man who underwent a reoperative neochord implantation for recurrent severe mitral regurgitation, resulting from degenerative disease progression with a new native chordal rupture. We report the midterm durability of reoperative Neochord repair.
Weekly variations of viruses and heterotrophic nanoflagellates and their potential impact on bacterioplankton in shallow waters of the central Red Sea
Authors: Sabbagh Eman I , Huete-Stauffer Tamara M , Calleja Maria L l , Silva Luis , Viegas Miguel , Morán Xosé Anxelu G 
Published: March 2020

ABSTRACTBacterioplankton play a pivotal role in marine ecosystems. However, their temporal dynamics and underlying control mechanisms are poorly understood in tropical regions such as the Red Sea. Here, we assessed the impact of bottom-up (resource availability) and top-down (viruses and heterotrophic nanoflagellates) controls on bacterioplankton abundances by weekly sampling a coastal central Red Sea site in 2017. We monitored microbial abundances by flow cytometry together with a set of environmental variables including temperature, salinity, dissolved organic and inorganic nutrients and chlorophyll a. We distinguished five groups of heterotrophic bacteria depending on their physiological properties relative nucleic acid content, membrane integrity and cell-specific respiratory activity, two groups of Synechococcus cyanobacteria and three groups of viruses. Viruses controlled heterotrophic bacteria for most of the year, as supported by a negative correlation between their respective abundances and a positive one between bacterial mortality rates and mean viral abundances. On the contrary, heterotrophic nanoflagellates abundance covaried with that of heterotrophic bacteria. Heterotrophic nanoflagellates showed preference for larger bacteria from both the high and low nucleic acid content groups. Our results demonstrate that top-down control is fundamental in keeping heterotrophic bacterioplankton abundances low (&lt; 5 × 10 5 cells mL−1) in Red Sea coastal waters.
Distinct Trajectories of Individual Physical Performance Measures Across 9 Years in 60- to 70-Year-Old Adults
Authors: Hoekstra Trynke , Rojer Anna Galina Maria , van Schoor Natasja M , Maier Andrea Britta , Pijnappels Mirjam 
Published: March 2020

Abstract

Background
Physical performance is an important factor for successful aging. This study aimed to identify distinct trajectories of multiple physical performance measures over 9 years in individuals aged 60–70 years and to evaluate their characteristics and the overlap between measures.

Methods
Four physical performance measures were assessed in 440 participants of the Longitudinal Aging Study Amsterdam: tandem stand, gait speed, chair stand, and handgrip strength. Gender-specific latent class models were conducted to obtain distinct trajectories and their degree of overlap.

Results
Mean age at baseline was 67.9 (SD 1.7) years for males and 68.0 (SD 1.7) years for females. The optimal number of trajectories differed across measures. For tandem stand, no distinct trajectories were found (all 179 males, 198 females). For gait speed, three trajectories were identified, dependent on baseline speed: high-stable (47 males, 27 females), intermediate-stable (132 males, 130 females), and low-declining performance (6 males, 48 females). Two trajectories were identified for the chair stand: a stable (168 males, 150 females) and declining trajectory (10 males, 38 females). For handgrip strength, three declining trajectories were identified differing in baseline performance: high (55 males, 75 females), intermediate (111 males, 118 females), and low (17 males, 10 females). Overall, 11.9% of males and 5.7% of females were classified in similar trajectories across measures.

Conclusions
Trajectories of physical performance were heterogeneous, but showed similar patterns for males and females. Little overlap between measures was shown, suggesting different mechanisms for decline. This study emphasizes the use of multiple domains to assess physical performance.
Kinematics and deformation of the southern Red Sea region from GPS observations
Authors: Viltres Renier , Jónsson Sigurjón , Ruch Joël , Doubre Cécile , Reilinger Robert , Floyd Michael , Ogubazghi Ghebrebrhan 
Published: March 2020

SUMMARY
The present-day tectonics of the southern Red Sea region is complicated by the presence of the overlapping Afar and southern Red Sea rifts as well as the uncertain kinematics and extent of the Danakil block in between. Here we combine up to 16 yr of GPS observations and show that the coherent rotation of the Danakil block is well described by a Danakil-Nubia Euler pole at 16.36°N, 39.96°E with a rotation rate of 2.83 deg Myr–1. The kinematic block modeling also indicates that the Danakil block is significantly smaller than previously suggested, extending only to Hanish-Zukur Islands (∼13.8°N) with the area to the south of the islands being a part of the Arabian Plate. In addition, the GPS velocity field reveals a wide inter-rifting deformation zone across the northern Danakil-Afar rift with ∼5.6 mm yr–1 of east–west opening across Gulf of Zula in Eritrea. Together the results redefine some of the plate boundaries in the region and show how the extension in the southern Red Sea gradually moves over to the Danakil-Afar rift.
Knockin mouse model of the human CFL2 p.A35T mutation results in a unique splicing defect and severe myopathy phenotype
Authors: Rosen Samantha M , Joshi Mugdha , Hitt Talia , Beggs Alan H , Agrawal Pankaj B 
Published: March 2020

Abstract
Cofilin-2 is an actin-binding protein that is predominantly expressed in skeletal and cardiac muscles and belongs to the AC group of proteins, which includes cofilin-1 and destrin. In humans, cofilin-2 (CFL2) mutations have been associated with congenital myopathies that include nemaline and myofibrillar myopathy. To understand the pathogenicity of the human CFL2 mutation, p.A35T, that first linked cofilin-2 with the human disease, we created a knock-in mouse model. The Cfl2A35T/A35T (KI) mice were indistinguishable from their wild-type littermates at birth, but they rapidly worsened and died by postnatal day 9. The phenotypic, histopathologic and molecular findings mimicked the constitutive Cfl2-knockout (KO) mice described previously, including sarcomeric disruption and actin accumulations in skeletal muscles and negligible amounts of cofilin-2 protein. In addition, KI mice demonstrated a marked reduction in Cfl2 mRNA levels in various tissues including skeletal muscles. Further investigation revealed evidence of alternative splicing with the presence of two alternate transcripts of smaller size. These alternate transcripts were expressed at very low levels in the wild-type mice and were significantly upregulated in the mutant mice, indicating that pre-translational splicing defects may be a critical component of the disease mechanism associated with the mutation. Evidence of reduced expression of the full-length CFL2 transcript was also observed in the muscle biopsy sample of the patient with p.A35T mutation.
A critical review of symbiosis approaches in the context of Industry 4.0☆
Authors: Scafà Martina , Marconi Marco , Germani Michele 
Published: March 2020

Abstract
The implementation of symbiosis approaches is recognized as an effective industrial strategy towards the optimization of resource exploitation and the improvement of collaboration in the context of Industry 4.0. An industrial system can be considered as a complex environment in which material, energy, machine, and human resources should cooperate towards the improvement of efficiency and the creation of value. According to this vision, the paper presents a detailed literature review about the existing symbiosis approaches: (i) industrial symbiosis models, which mainly aim at the sharing of resources among different companies, and (ii) human symbiosis, which focuses on how to effectively strengthen the synergy among humans and machines. Strengths, weaknesses and correlations among the most common symbiosis approaches are analysed and classified. Finally, the existing symbiosis models are related with the pillars of the Industry 4.0 paradigm, in order to understand what should be the future directions of research in the context of collaborative manufacturing.
Datana drexelii (Lepidoptera: Notododontidae) Occurrence and Larval Survival on Highbush Blueberry Cultivars
Authors: Baranowski Alex K , Alm Steven R , Preisser Evan L 
Published: March 2020

Abstract
Plant genotype influences plant suitability to herbivores; domesticated plants selected for properties such as high fruit yield may be particularly vulnerable to herbivory. Cultivated strains of highbush blueberry, Vaccinium corymbosum L. can be high-quality hosts for larvae of the gregariously feeding notodontid Datana drexelii (Hy. Edwards). We conducted an experiment assessing D. drexelii larval survival and pupal weight when fed foliage from five blueberry cultivars: ‘Bluecrop’, ‘Bluetta’, ‘Blueray’, ‘Lateblue’, and ‘Jersey’. We complemented this experimental work with repeated bush-level surveys of a managed blueberry patch for naturally occurring D. drexelii larval clusters. Larval survival and pupal weight were significantly higher on ‘Lateblue’ foliage than from the ‘Bluecrop’, ‘Bluetta’, and ‘Jersey’ cultivars. The blueberry patch surveys found more D. drexelii larval clusters on ‘Bluehaven’, ‘Collins’, and ‘Darrow’ bushes than on the cultivars ‘Earliblue’ and ‘Jersey’. The low D. drexelii occurrence and performance on the ‘Jersey’ cultivar suggests that this variety may be appropriate for areas where this pest is common; conversely, their high occurrence on ‘Bluehaven’ ‘Collins’, and ‘Darrow’ suggests that these cultivars may be particularly vulnerable. Cultivar-level variation in herbivore vulnerability highlights how understanding plant–pest interactions can help manage agricultural species.
Outcome Assessment in Epidemiological Studies of Low-Dose Radiation Exposure and Cancer Risks: Sources, Level of Ascertainment, and Misclassification
Authors: Linet Martha S , Schubauer-Berigan Mary K , Berrington de González Amy 
Published: March 2020

AbstractBackgroundOutcome assessment problems and errors that could lead to biased risk estimates in low-dose radiation epidemiological studies of cancer risks have not been systematically evaluated.MethodsIncidence or mortality risks for all cancers or all solid cancers combined and for leukemia were examined in 26 studies published in 2006–2017 involving low-dose (mean dose ≤100 mGy) radiation from environmental, medical, or occupational sources. We evaluated the impact of loss to follow-up, under- or overascertainment, outcome misclassification, and changing classifications occurring similarly or differentially across radiation dose levels.ResultsLoss to follow-up was not reported in 62% of studies, but when reported it was generally small. Only one study critically evaluated the completeness of the sources of vital status. Underascertainment of cancers (“false negatives”) was a potential shortcoming for cohorts that could not be linked with high-quality population-based registries, particularly during early years of exposure in five studies, in two lacking complete residential history, and in one with substantial emigration. False positives may have occurred as a result of cancer ascertainment from self- or next-of-kin report in three studies or from enhanced medical surveillance of exposed patients that could lead to detection bias (eg, reporting precancer lesions as physician-diagnosed cancer) in one study. Most pediatric but few adult leukemia studies used expert hematopathology review or current classifications. Only a few studies recoded solid cancers to the latest International Classification of Diseases or International Classification of Diseases for Oncology codes. These outcome assessment shortcomings were generally nondifferential in relation to radiation exposure level except possibly in four studies.ConclusionThe majority of studies lacked information to enable comprehensive evaluation of all major sources of outcome assessment errors, although reported data suggested that the outcome assessment limitations generally had little effect on risk or biased estimates towards the null except possibly in four studies.
Precedent in the WTO: Retrospective Reflections for a Prospective Dispute Settlement Mechanism
Authors: de Andrade Mariana Clara 
Published: March 2020

Abstract
Several factors triggered the legitimacy crisis which paralysed the WTO Appellate Body in December 2019. This article focuses on one of them: the criticism expressed by the United States that the ‘Appellate Body claims its reports are entitled to be treated as precedent’. This work describes the origins of the problem and examines the issue of the precedential value of adopted reports within the WTO dispute settlement. It argues that the problem cannot be addressed through textual attempts to better define the value of precedent, as some have suggested, but can be alleviated through the practice of adjudicators. Moreover, it argues that the criticisms regarding the precedential value of past reports is due to the inherent hierarchy ensuing from the existence of an appeals organ. Therefore, the demise of the Appellate Body may weaken the precedential value of past adopted reports.
White Devils, Satanic Jews: The Nation of Islam From Fard to Farrakhan
Authors: Norwood Stephen H , Pollack Eunice G 
Published: March 2020

Abstract
This article explores how the American white far right—including the Christian Front, Christian Mobilizers, and Gerald L. K. Smith—helped shape the Nation of Islam’s (NOI) antisemitism during the 1930s and 1940s. It also examines the strong influence of Harlem’s pro-Axis Black Fuehrers on the NOI during World War II. Nation of Islam and white far-right propaganda were remarkably similar. Both embraced the Protocols of the Learned Elders of Zion, denied or minimized the Holocaust, and were virulently anti-Zionist. After elaborating on the context within which the Nation of Islam created its ideology, the article explores how the NOI, which originally identified whites, Christians and Jews as devils, adopted an almost singular emphasis on Jews as agents of Satan, the Star of David replacing the cross as the symbol of iniquity. Jews were not victims, but Blacks’ major victimizers; never slaves, but dominant enslavers; not progressives, but those who impeded Blacks’ advance. Instead of giving the world Hebrew Scripture, they converted it into the “Poison Book,” from the beginning crafting a “dirty religion,” which blessed the subjugation of black people, and denied God’s promise to the “Real Children of Israel.” These “imposter Jews” concealed that the Hebrew Bible was a prophecy about “the so-called Negroes of America”—the true “Chosen of God”—who would be in bondage for 400 years, strangers in a strange land.
Collision between molecular clouds – I. The effect of the cloud virial ratio in head-on collisions
Authors: Tanvir Tabassum S , Dale James E 
Published: March 2020

ABSTRACT
In a series of papers, we investigate the effect of collisions between turbulent molecular clouds on their structure, evolution, and star formation activity. In this paper, we look into the role of the clouds’ initial virial ratios. Three different scenarios were examined: both clouds initially bound, one cloud bound and one unbound, and both clouds initially unbound. Models in which one or both clouds are bound generate filamentary structures aligned along the collision axis and discernible in position–position and position–velocity space. If neither cloud is bound, no filaments result. Unlike in previous simulations of collisions between smooth clouds, owing to the substructure created in the clouds by turbulence before the collisions, dissipation of kinetic energy by the collision is very inefficient and in none of our simulations is sufficient bulk kinetic energy lost to render the clouds bound. Simulations where both clouds are bound created twice as much stellar mass than the bound–unbound model, and both these scenarios produced much more stellar mass than the simulation in which both clouds are unbound. Each simulation was also compared with a control run in which the clouds do not collide. We find the bound–bound collision increases the overall star formation efficiency by a factor of approximately two relative to the control, but that the bound–unbound collision produces a much smaller increase, and the collision has very little effect on the unbound–unbound cloud collision.
Urgent Treatment for Symptomatic Carotid Stenosis: The Pittsburgh Revascularization and Treatment Emergently After Stroke (PIRATES) Protocol
Authors: Jankowitz Brian T , Tonetti Daniel A , Kenmuir Cynthia , Rao Rahul , Ares William J , Zussman Benjamin , Brown Merritt W , Stone Jeremy G , Gardner Paul A , Friedlander Robert M , Gross Bradley A , Jadhav Ashutosh P , Jovin Tudor G 
Published: March 2020

Abstract

BACKGROUND
Patients with symptomatic carotid stenosis remain at high risk of early recurrent stroke without revascularization. This risk must be balanced against a higher rate of periprocedural complications associated with early revascularization.

OBJECTIVE
To analyze prospectively recorded data from an institutional protocol that standardized the urgent (<48 h) treatment of patients presenting with symptomatic carotid stenosis and underwent either carotid stenting (CAS) or carotid endarterectomy (CEA).

METHODS
All patients presenting over 28 mo to a comprehensive stroke center with symptomatic carotid stenosis within 48 h of index event were screened for inclusion. All patients were given dual-antiplatelet therapy. If there was clinical equipoise between CEA and CAS, patients underwent angiography and subsequently revascularization if digital subtraction angiography demonstrated ≥50% stenosis. The primary outcome was a composite of stroke or death within 30 d.

RESULTS
This study included 178 patients with a diagnosis of recently symptomatic carotid stenosis; 120 patients (67%) met the criteria. A total of 59 patients underwent CEA and 61 patients underwent CAS. There were not significant differences in the primary outcome; 3 patients (5.1%) in the CEA arm and 3 patients (4.9%) in the CAS arm met the primary outcome.

CONCLUSION
In this prospective analysis, urgent revascularization for symptomatic carotid stenosis can be done with equivalently low rates of stroke or death, regardless of revascularization strategy.
A Novel Foraminoplasty Technique for Posterolateral Percutaneous Transforaminal Endoscopic Lumbar Surgery
Authors: Liu Xinchun , Peng Yunfei 
Published: March 2020

Abstract

BACKGROUND
In posterolateral percutaneous transforaminal endoscopic lumbar surgery, foraminoplasty is currently performed by resecting part of the superior articular process together with surrounding soft tissues. This procedure remains technically demanding. An ideal foraminoplasty technique should be safe, easy, efficient, and controllable and should minimize X-ray exposure.

OBJECTIVE
To introduce a novel foraminoplasty technique that is designed in an attempt to obtain the ideal state.

METHODS
The technique is introduced step by step by case illustration. Briefly, the technique is based on the addition of a novel instrument, named a “Foraminoplasty Working Tube,” to the commercialized spinal endoscope system. Through the foraminoplasty working tube, the foraminoplasty procedure can be performed under either reduced X-ray guidance or direct endoscopic view.

RESULTS
The technique allows the surgeon to perform an accurate resection of the superior articular process by easily adjusting the foraminoplasty working tube to the target area. To a great extent, the volume of the bone resected is predictable and controllable and just meets the demands of the operation without excessive resection of the superior articular process.

CONCLUSION
The present technique would potentially be a safer, easier, and more efficient foraminoplasty technique.