bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Low‐Cost Durable Na‐FeCl2 Battery with Ultrahigh Rate Capability
Authors: Zhan Xiaowen , Bowden Mark E. , Lu Xiaochuan , Bonnett Jeffery F. , Lemmon Teresa , Reed David M. , Sprenkle Vincent L. , Li Guosheng 
Published: January 2020

AbstractNa‐based batteries have long been regarded as an inexpensive, sustainable candidate for large‐scale stationary energy storage applications. Unfortunately, the market penetration of conventional Na‐NiCl2 batteries is approaching its limit for several reasons, including limited rate capability and high Ni cost. Herein, a Na‐FeCl2 battery operating at 190 °C is reported that allows a capacity output of 116 mAh g−1 at an extremely high current density of 33.3 mA cm−2 (≈0.6C). The superior rate performance is rooted in the intrinsically fast kinetics of the Fe/Fe2+ redox reaction. Furthermore, it is demonstrated that a small amount of Ni additive (10 mol%) effectively mitigates capacity fading of the Fe/NaCl cathode caused by Fe particle pulverization during long‐term cycling. The modified Fe/Ni cathode exhibits excellent cycling stability, maintaining a discharge energy density of over 295 Wh kg−1 for 200 cycles at 10 mA cm−2 (≈C/5).
KPTN gene homozygous variant‐related syndrome in the northeast of Brazil: A case report
Authors: Lucena Pedro H. , Armani‐Franceschi Giulia , Bispo‐Torres Ana Cecília , Bandeira Igor D. , Lucena Mariana F. G. , Maldonado Igor , Veiga Marielza F. , Miguel Diego , Lucena Rita 
Published: January 2020

AbstractAlteration of the KPTN gene, responsible for the coding of kaptin (a protein involved in actin cytoskeletal dynamics), causes a syndrome characterized by macrocephaly, neurodevelopmental delay and epileptic seizures. We report the first Brazilian case of KPTN gene variation, previously described in nine subjects from four interlinked families from an Amish community in Ohio, two Estonian siblings and a 9‐year‐old boy from Kansas City. We report a case of KPTN‐related syndrome in a 5‐year‐old child which presented macrocephaly, muscular hypotonia, and global development delay. The neurological examination revealed below‐expected performance in coordination and balance tests, dyspraxia, and hand‐mouth synkinesia. Expressive language was characterized by phono‐articulatory imprecision, abundance of phonological processes and morphosyntactic immaturity. Neuropsychological assessment revealed intellectual disability with impairment of verbal and executive functions. Exome sequencing was performed. Analysis revealed a homozygous 2‐nucleotide duplication c.597_598dup p.(Ser200Ilefs*55) in the KPTN gene, which is predicted to lead to a translational frameshift and formation of a premature stop codon. The phenotypic profile is similar to the cases described in the other families. Presence of macrocephaly and delayed development indicate the possibility of KPTN gene variation. Genetic testing should be carried out at an early stage in order to reach a timely diagnosis.
Two unrelated families with variable expression of Fraser syndrome due to the same pathogenic variant in the FRAS1 gene
Authors: Midro Alina T. , Stasiewicz‐Jarocka Beata , Borys Jan , Hubert Ewa , Skotnicka Bożena , Hassmann‐Poznańska Elżbieta , Sierpińska Teresa , Panasiuk Barbara , Schanze Denny , Zenker Martin 
Published: January 2020

AbstractWe report on two unrelated families of Polish origin with variable expression of Fraser syndrome (FS; MIM#219000) due to homozygosity for the same pathogenic variant, c.6963_6964dup, of FRAS1. In one family, the disorder presented with perinatal and prenatal lethality. One affected female from family 2 who was followed‐up for 32 years, represented a relatively favorable long‐term outcome. She displayed the typical craniofacial dysmorphism, including right cryptophthalmos, cutaneous syndactyly, abnormalities of the stomathognatic system, bilateral atresia of the external ear canals resulting in conductive hearing loss, and malformations of the larynx, spleen, kidney, and genitourinary tract. Her intellectual capacities were normal. Our observations illustrate that expression and severity of FS, even when caused by the same pathogenic variant, may be quite different ranging from a lethal disorder to a condition with multiple physical malformations but normal psychomotor development. In addition, we propose that the FRAS1 c.6963_6964dup variant may be a founder mutation in the Polish population. Therefore, it would be reasonable to test specifically for this variant first in any FS1 patient of Polish ancestry.
Self‐Aggregation of Oligomethylene‐Tethered Diketopyrrolopyrrole Dimers
Authors: Lin Xu , Okazawa Yusuke , Tani Yuki , Ouchi Hayato , Nakayama Ken‐ichi , Yagai Shiki 
Published: January 2020

AbstractTwo diketopyrrolopyrrole dimers with different oligomethylene tether length showed distinct aggregation behaviours, leading to a significant difference in the degree of phase separation upon mixing with PC61BM. Despite almost same optical properties, their blend films with PC61BM exhibited distinct power conversion efficiency in bulk‐heterojunction solar cells as a result of difference in phase separation.
CHIT1 at Diagnosis Reflects Long‐Term Multiple Sclerosis Disease Activity
Authors: Oldoni Emanuela , Smets Ide , Mallants Klara , Vandebergh Marijne , Van Horebeek Lies , Poesen Koen , Dupont Patrick , Dubois Bénédicte , Goris An 
Published: January 2020

ObjectiveEvidence for a role of microglia in the pathogenesis of multiple sclerosis (MS) is growing. We investigated association of microglial markers at time of diagnostic lumbar puncture (LP) with different aspects of disease activity (relapses, disability, magnetic resonance imaging parameters) up to 6 years later in a cohort of 143 patients.MethodsIn cerebrospinal fluid (CSF), we measured 3 macrophage and microglia‐related proteins, chitotriosidase (CHIT1), chitinase‐3–like protein 1 (CHI3L1 or YKL‐40), and soluble triggering receptor expressed on myeloid cells 2 (sTREM2), as well as a marker of neuronal damage, neurofilament light chain (NfL), using enzyme‐linked immunosorbent assay and electrochemiluminescence. We investigated the same microglia‐related markers in publicly available RNA expression data from postmortem brain tissue.ResultsCHIT1 levels at diagnostic LP correlated with 2 aspects of long‐term disease activity after correction for multiple testing. First, CHIT1 increased with reduced tissue integrity in lesions at a median 3 years later (p = 9.6E‐04). Second, CHIT1 reflected disease severity at a median 5 years later (p = 1.2E‐04). Together with known clinical covariates, CHIT1 levels explained 12% and 27% of variance in these 2 measures, respectively, and were able to distinguish slow and fast disability progression (area under the curve = 85%). CHIT1 was the best discriminator of chronic active versus chronic inactive lesions and the only marker correlated with NfL (r = 0.3, p = 0.0019). Associations with disease activity were, however, independent of NfL.InterpretationCHIT1 CSF levels measured during the diagnostic LP reflect microglial activation early on in MS and can be considered a valuable prognostic biomarker for future disease activity. ANN NEUROL 2020;87:633–645
Thioguanosine Conversion Enables mRNA‐Lifetime Evaluation by RNA Sequencing Using Double Metabolic Labeling (TUC‐seq DUAL)
Authors: Gasser Catherina , Delazer Isabel , Neuner Eva , Pascher Katharina , Brillet Karl , Klotz Sarah , Trixl Lukas , Himmelstoß Maximilian , Ennifar Eric , Rieder Dietmar , Lusser Alexandra , Micura Ronald 
Published: January 2020

AbstractTemporal information about cellular RNA populations is essential to understand the functional roles of RNA. We have developed the hydrazine/NH4Cl/OsO4‐based conversion of 6‐thioguanosine (6sG) into A′, where A′ constitutes a 6‐hydrazino purine derivative. A′ retains the Watson–Crick base‐pair mode and is efficiently decoded as adenosine in primer extension assays and in RNA sequencing. Because 6sG is applicable to metabolic labeling of freshly synthesized RNA and because the conversion chemistry is fully compatible with the conversion of the frequently used metabolic label 4‐thiouridine (4sU) into C, the combination of both modified nucleosides in dual‐labeling setups enables high accuracy measurements of RNA decay. This approach, termed TUC‐seq DUAL, uses the two modified nucleosides in subsequent pulses and their simultaneous detection, enabling mRNA‐lifetime evaluation with unprecedented precision.
Iron(II)‐Catalyzed Biomimetic Aerobic Oxidation of Alcohols
Authors: Guðmundsson Arnar , Schlipköter Kim Elisabeth , Bäckvall Jan‐E. 
Published: January 2020

AbstractWe report the first FeII‐catalyzed biomimetic aerobic oxidation of alcohols. The principle of this oxidation, which involves several electron‐transfer steps, is reminiscent of biological oxidation in the respiratory chain. The electron transfer from the alcohol to molecular oxygen occurs with the aid of three coupled catalytic redox systems, leading to a low‐energy pathway. An iron transfer‐hydrogenation complex was utilized as a substrate‐selective dehydrogenation catalyst, along with an electron‐rich quinone and an oxygen‐activating Co(salen)‐type complex as electron‐transfer mediators. Various primary and secondary alcohols were oxidized in air to the corresponding aldehydes or ketones with this method in good to excellent yields.
Lymphedema and Lymphovenous Bypass: Perioperative Nursing Implications
Authors: Whitnell Lori A. 
Published: January 2020

ABSTRACTLymphedema—the accumulation of fluid in tissues, usually in the upper and lower extremities—often results from lymph node dissection or radiation and can cause painful and debilitating swelling that may interfere with a patient's daily living activities and quality of life. The goal of treatment for lymphedema is to reduce the volume of fluid in the affected area. Lymphedema is staged according to presenting characteristics, and interventions may be surgical or nonsurgical, such as complex decongestive therapy. Lymphovenous bypass is a surgical procedure performed for the management of lymphedema and involves rerouting microvascular channels to allow for the drainage of fluid that has accumulated in the lymphatic tissue of the upper or lower extremities. It requires supermicrosurgery techniques because of the small size of the vessels being anastomosed. Perioperative nursing implications for lymphovenous bypass include OR preparation and providing emotional support for patients living with lymphedema.
A Qualitative Exploratory Study of Norwegian OR Nurses’ Patient Positioning Priorities
Authors: Brooker Kathrine Johnsen , Vikan Magnhild , Thyli Bente 
Published: January 2020

ABSTRACTThe purpose of patient positioning is to provide optimal surgical site exposure for surgical team members and prevent negative patient outcomes. This study explores perioperative nurses’ experiences when positioning patients for surgery. We collected data using focus group interviews of 17 OR nurses in Norway and used qualitative content analysis to analyze the data. The study findings showed that perioperative nurses emphasized their most important priorities as concepts that can be categorized into three themes: leading and coordinating patient positioning, ensuring patient safety, and promoting efficient use of OR nurses’ expertise. The study findings also identify a need to define formal responsibilities in patient positioning and processes for determining positioning outcomes. Perioperative leaders should verify OR nurse competence for patient positioning to help ensure continuity and safety in complex patient pathways.
Clinical Issues—February 2020
Authors: Anderson Mary Alice 
Published: January 2020

THIS MONTH
Environmental cleaning requirements for methicillin‐resistant

Staphylococcus aureus

Key words: environmental cleaning, enhanced cleaning, methicillin‐resistant Staphylococcus aureus (MRSA), personal protective equipment (PPE), high‐touch surfaces.
Isolation technique for cancer cells
Key words: isolation technique, seeding, cancer cells, sterile field, resection.
Teamwork and patient safety culture
Key words: patient safety culture, human factors, nontechnical skills (NTS), teamwork, communication.
Personal glasses and changing side shields
Key words: glasses, side shield, eyewear, personal protective equipment (PPE), goggles.
Multiscale thermal study of virgin and aged polyphenylene sulfide reinforced by glass fiber
Authors: Zuo Peiyuan , Tcharkhtchi Abbas , Fitoussi Joseph , Shirinbayan Mohammadali , Bakir Farid 
Published: January 2020

AbstractIn this study, virgin and thermal aged PPS samples were prepared and tested using different techniques such as thermogravimetric analysis (TGA), coupled TGA–Fourier transform infrared spectroscopy (FTIR), and FTIR as well as optical microscopy. Some interesting research results can be summarized as follows: TGA results prove the PPS composite samples aged at 180 and 200°C have been degraded obviously during the aging period in oven. Moreover, accelerated aging leads to the degradation of PPS composite with the observation of increased thermal oxidation layer from outside to inside. There is a plateau standing at about 350 μm for the thermal oxidation layer at oxidation temperature of 200°C. Some thermal decomposition models are applied to clarify the degradation kinetics of PPS composite. According to the activation energy value, it appears degradation more easily at the beginning of the heating process in the atmosphere of oxygen than that of nitrogen. Moreover, the related products of PPS composites during pyrolysis are fully discussed with the combined analysis of TGA–FTIR techniques.
Carbon fiber‐embedded bacterial cellulose/polyaniline nanocomposite with tailored for microbial fuel cells electrode
Authors: Trindade Elizabeth C. A. , Antônio Regina V. , Brandes Ricardo , de Souza Letícia , Neto Gabriel , Vargas Vanessa M. M. , Carminatti Claudimir A. , de Oliveira Souza Recouvreux Derce 
Published: January 2020

AbstractMicrobial fuel cells (MFC) are of great interest for new sources of renewable energies from the waste of biomass and debris. This work aimed was to develop an anode electrode of the carbon fiber‐embedded of bacterial cellulose/polyaniline (CF/BC/PANI) nanocomposite for MFC applications. For this purpose, carbon fiber was wrapped onto bacterial cellulose (BC) fibers network during the BC synthesis. The CF/BC/PANI was obtained by polyaniline polymerization on the BC nanofibers as a scaffold. To characterize the electrode, scanning electron microscopy, Fourier‐transform infrared spectroscopy, X‐ray diffraction, and thermogravimetric analysis analysis were carried out. The electrical conductivity was determined by measuring the resistivity. MFC using the CF/BC/PANI electrode was monitored and the maximum current density generated was 0.009 mA/cm2. The results obtained from the CF/BC/PANI demonstrate great potential for the use as an MFC electrode, as well as a microenvironment favorable to a microbial biofilm formation.
Output feedback control for an underactuated benchmark system with bounded torques
Authors: Wu Xianqing , Xu Kexin , Ma Miao , Ke Liuting 
Published: January 2020

AbstractIn this paper, we consider the stabilization of the translational oscillator with a rotational actuator (TORA) system. Existing control methods for the TORA system are developed on the basis of the assumptions that full state feedback is available, and the actuator can supply control torques with any bounded amplitudes or system parameters are exactly known. In order to relax these assumptions, an amplitude‐saturated output feedback controller is proposed for the TORA system. Compared with existing control methods, the proposed method exhibits four remarkable features: free of plant parameters, bounded amplitude, output feedback, and unwinding behavior prevention. Specifically, the passivity of the TORA system is analyzed first. Then, a constructive energy‐like function is introduced and a corresponding amplitude‐saturated output feedback control law for the TORA system is proposed on the basis of the constructed energy‐like function. Lyapunov‐based analysis and LaSalle's invariance principle are used to prove the boundedness and convergence of the closed‐loop signals. Finally, numerical simulations with comparisons to previous reported methods are implemented to demonstrate the superior performance of the proposed method.
Study of trivalent samarium ion embedded lithium‐based borate glass for high‐density optical memory devices
Authors: Rao Narasimsetti Srinivasa , Rajesh Megala , Prasad Kumcham , Reddy Gutturu Rajasekhara , Raju B. Deva Prasad , Dhanapandian S. 
Published: January 2020

AbstractSm3+ ions doped strontium lithium lead borate glasses (SLLB:Sm) were prepared using a conventional melt‐quenching technique. The glasses were analyzed using X‐ray diffractometry and Fourier transform infrared spectroscopy, optical absorption, fluorescence spectral analysis, and fluorescence lifetime decay. The Judd–Ofelt (J–O) parameters and radiative parameters of the SLLB:Sm10 glass (1.0 mol% Sm3+ ion‐doped glass) were calculated using J–O theory. From the emission spectra, among all the synthesized glass, SLLB:Sm10 glass had the highest emission intensity for 4G5/2→6H11/2 transition (610 nm). Emission parameters, such as stimulated emission cross‐section and optical gain bandwidth, were calculated. For all concentrations of Sm3+ ions, the decay profile showed an exponential nature and decreased when the Sm3+ ion concentration was increased due to a concentration quenching effect. This result suggests that the synthesized SLLB:Sm10 glass could be used for application in high‐density optical memory devices.
Discriminative detection of mercury (II) and hydrazine using a dual‐function fluorescent probe
Authors: Wu Xiaoming , Li Yanan , Yang Shaoxiang , Tian Hongyu , Sun Baoguo 
Published: January 2020

AbstractA dual‐function fluorescent probe (Probe 1) was developed for discriminative detection of Hg2+ and N2H4. Probe 1 could discriminatively detect Hg2+ and N2H4 through two different reaction sites, with the mechanism for Probe 1 for Hg2+ depending on a desulfurization reaction and for N2H4 depending on the Schiff‐base reaction. N2H4 had minimal effect on Hg2+ detection in dimethyl sulfoxide (DMSO)/H2O solution, but Hg2+ could interfere with N2H4 detection in DMSO/buffer solution. Different concentrations of Hg2+ and N2H4 resulted in different blue shades of Probe 1 test strips, and the shade of blue was different with the same concentration of Hg2+ or N2H4, as observed under ultraviolet light at 365 nm wavelength.
Rapid profiling of cantharidin analogs in Mylabris phalerata Pallas by ultra‐performance liquid chromatography–quadrupole time‐of‐flight–tandem mass spectrometry
Authors: Zeng Yaobo , Guo Yanlei , Zhang Yi , Wang Xianying , Jiang Yao , Yang Dajian 
Published: January 2020

AbstractWe evaluated the protective effect and toxicity of extracts from Mylabris phalerata Pallas by measuring the activated partial thromboplastin time, prothrombin time, venous thrombosis and acute toxicity in rats. Results showed the petroleum ether and water fractions of M. phalerata inhibited thrombosis but hardly prolonged the activated partial thromboplastin time and prothrombin time in rats. The trichloromethane fraction had obvious toxicity with an LD50 of 0.2 g/kg in vivo, and contained many cantharidin analogs (CAs) by ultra‐performance liquid chromatography–quadrupole ion trap–tandem mass spectrometry (UPLC–QTRAP–MS/MS). CAs are the major potential bioactivity constituent in M. phalerata. An effective and reliable UPLC–QTRAP–MS/MS method was successfully developed to separate and identify CAs. The fragmentation patterns of five purified compounds were applied to elucidate the structure of their analogs. Thirty‐four CAs were characterized or tentatively identified, eight of which are proposed to be novel compounds (13–17, 20, 21, 23), and their fragmentation patterns were investigated for the first time. Most importantly, a rapid and reliable UPLC–MS method was developed to identify the CAs of M. phalerata. This method has contributed to the discovery of most of these unknown analogs or their metabolites in M. phalerata effectively and quickly, and does not rely on limited chemical structural diversity libraries.
Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer‐like behavioral and neuropathological changes in CD‐1 mice
Authors: Wang Fang , Zhang Zhe‐Zhe , Cao Lei , Yang Qi‐Gang , Lu Qing‐Fang , Chen Gui‐Hai 
Published: January 2020

AbstractIntroductionInfections could contribute to Alzheimer's disease (AD) neuropathology in human. However, experimental evidence for a causal relationship between infections during the prenatal phase and the onset of AD is lacking.MethodsCD‐1 mothers were intraperitoneally received lipopolysaccharide (LPS) with two doses (25 and 50 μg/kg) or normal saline every day during gestational days 15–17. A battery of behavioral tasks was used to assess the species‐typical behavior, sensorimotor capacity, anxiety, locomotor activity, recognition memory, and spatial learning and memory in 1‐, 6‐, 12‐, 18‐, and 22‐month‐old offspring mice. An immunohistochemical technology was performed to detect neuropathological indicators consisting of amyloid‐β (Aβ), phosphorylated tau (p‐tau), and glial fibrillary acidic protein (GFAP) in the hippocampus.ResultsCompared to the same‐aged controls, LPS‐treated offspring had similar behavioral abilities and the levels of Aβ42, p‐tau, and GFAP at 1 and 6 months old. From 12 months onward, LPS‐treated offspring gradually showed decreased species‐typical behavior, sensorimotor ability, locomotor activity, recognition memory, and spatial learning and memory, and increased anxieties and the levels of Aβ42, p‐tau, and GFAP relative to the same‐aged controls. Moreover, this damage effect (especially cognitive decline) persistently progressed onwards. The changes in these neuropathological indicators significantly correlated with impaired spatial learning and memory.ConclusionsPrenatal exposure to low doses of LPS caused AD‐related features including behavioral and neuropathological changes from midlife to senectitude.