bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Prehospital Arterial Hypercapnia in Acute Heart Failure and Admission to Acute Care Units : A Retrospective Cohort Study
Authors: Fabre Mathias , Fehlmann Christophe A. , Gartner Birgit , Zimmermann-Ivoll Catherine G. , Rey Florian , Sarasin François , Suppan Laurent 
Published: May 2020

Abstract
Background: Acute Heart Failure (AHF) is a common condition that often manifests by acute respiratory distress and requires urgent medical evaluation and treatment. Arterial hypercapnia is common in AHF. It has been associated with a higher rate of intubation and non-invasive ventilation in the Emergency Room (ER), but its prognostic value has never been studied in the prehospital setting. Methods: A retrospective study was performed on the charts of all patients taken care of by a physician-staffed prehospital mobile unit between June 2016 and September 2019 in Geneva. After approval by the ethics committee, charts were screened to identify all adult patients with a diagnosis of AHF. The main predictor was prehospital hypercapnia. The primary outcome was admission rate in an acute care unit (ACU, composite of intensive care or high-dependency units). Secondary outcomes were ER length of stay (LOS), orientation from ER (intensive care unit, high-dependency unit, general ward, discharge home), intubation rate at 24 hours, hospital LOS and hospital mortality. Results: A total of 104 patients with a diagnosis of AHF were included. Hypercapnia was found in 59 (57%) patients and vital signs were more severely altered in this group. The overall ACU admission rate was 47%, with a statistically significant difference between hypercapnic and non-hypercapnic patients (58% vs 33% respectively, p=0.014). ER LOS was shorter in hypercapnic patients (5.5 hours vs 8.9 hours, p=0.008). Conclusions: There is a significant association between prehospital arterial hypercapnia and acute care unit admission in AHF patients. Trial Registration:This study was approved on 20.08.2019 by the institutional ethics committee of Geneva, Switzerland (Project ID 2019-01559)
The Effects of Corticosteroids on the Respiratory Microbiome: A Systematic Review
Authors: Hartmann Julia Evelyn , Albrich Werner C. , Dmitrijeva Marija , Kahlert Christian R. 
Published: May 2020

Abstract
Background: Since its discovery, the respiratory microbiome has been implicated in the pathogenesis of multiple pulmonary diseases. Even though corticosteroid treatments are widely prescribed for pulmonary diseases, their effects on the respiratory microbiome are still poorly understood. This systematic review summarises the current understanding of the effects of corticosteroids on the microbiome of the airways. The primary outcomes of interest were changes in the diversity, composition and total burden of the respiratory microbiome as assessed by culture-independent molecular methods.Results: According to the PRISMA guidelines, Embase, Medline, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases were systematically searched for all observational or randomised-controlled studies comparing the microbiome parameters of patients receiving corticosteroids to those of controls. Only five studies out of 1943 identified reports could be included: two on patients with asthma, two on patients with chronic obstructive pulmonary disease and one on patients with chronic rhinosinusitis. The studies were highly heterogeneous with regards to the methods used and the populations investigated. Microbiome diversity increased with corticosteroids at least transiently in 3 studies and decreased in one study. The effects of corticosteroids on the composition of the respiratory microbiome were significant but without a clear shared direction. A significant increase in microbial burden after corticosteroids was seen in one study. Conclusions: Data on the effect of corticosteroids on the respiratory microbiome are still limited, with considerable heterogeneity between studies. However, available data suggest that corticosteroid treatment may have significant effects on the composition and possibly the diversity of the respiratory microbiome.
High Incidence of Implant Failure Happened Using Anterior-posterior Screws for the Fixation of Tibial Posterior Pilon Fracture.
Authors: Wang Hao , Zheng Huayong , Lv Dongdong , Li Lianhua , Zhang Jianzheng , Sun Tiansheng 
Published: May 2020

Abstract
Objective：To explore the mechanism of posterior pilon fracture with different proportion of the medial malleolus involved and evaluate clinical outcomes of anterior-posterior screws fixation.Methods: Patients admitted to our hospital with diagnosis of tibial posterior Pilon fracture were identified from January 2014 to January 2018. Mechanism from medical history, proportion of the medial malleolus involved (not involved/partial involved /total involved) from axial CT sacn were recorded to figure out the mechanism . Burwell—Charnley radiographic criteria of reduction, American orthopaedic Foot＆Ankle society ankle-hindfoot scale at 12 month follow-up were recorded to evaluate the curative effect of anterior-posterior screws fixation.Result: Sixty-nine patients were identified in this retrospective study. 43 males and 26 females were included, with mean age 46.9 years old（range, 21-76 years）. Mechanism of the 8 cases with fracture line do not involve midial malleolus but accompanied with die-punch fragment included 4 ground level fall, 2 fall off stairs, 1 sport injury, 1 fall from bike. Mechanism of the 52 cases with midial malleolus partial involved included 14 motor vehicle accident, 14 fall off stairs, 5 sport injury, 3 fall from bike and 16 fall from height. Mechanism of the 9 cases with medial malleolus totally involved included 6 falling from height, 2 falling of stairs and 1 motor vehicle accident. Five patients were treated with the fixation of Anterior-Posterior screws, fracture line of four cases do not involve midial malleolus and the rest one partial involved. The Burwell—Charnley radiographic criteria of reduction were fair in 4 and poor in one on the post-operation X-ray. Three of them got implant failure. The AOFAS ankle-hindfoot scale 12-month post-operation for the rest two patients were 78 and 72.Conclusion: There is a high risk of implant failure using A-P screws for the treatment of posterior pilon fracture. The mechanism of posterior fracture involve medial malleolus is mainly vertical force .
Double-Hoist Dynamics and Oscillation Control of a Quadcopter Carrying a Swinging and Twisting Load
Authors: Zhu Kuo , Huang Jie , Zhang Yifan 
Published: May 2020

Abstract
Quadcopters can serve as aerial cranes that are able to suspend large-size loads below the fuselage for material-handling services. Double-hoist mechanisms help quadcopter to transport bulky loads effectively. However, double-hoist mechanisms exhibit strong coupling effect among the quadcopter’s attitude, load swing, and load twisting. Different from the single-hoist mechanisms, no effects have been directed at quadcopter slung loads with double-hoist mechanisms. A novel nonlinear dynamics model of a quadcopter carrying a distributed-mass load by double-hoist mechanisms is given in this paper. This explicit model captures the coupling between the quadcopter and load motion. Then a novel control method is proposed to reduce the swing and twisting of the load simultaneously. The simulation results illustrate that the control method succeeds in limiting the unwanted oscillations of quadcopter attitudes, load swing and twisting.
A Novel Force Oscillations Reduction Method Based on Nonlinear Tracking Differentiator for Robotic Contact Transition Process
Authors: Li Xiang-Fei , Zhao Huan , Ding Han 
Published: May 2020

Abstract
Impedance control is an effective force tracking approach for robotic contact operation tasks such as grinding/polishing, deburring, assembly and dexterous hand manipulations, etc. Within the impedance control framework, when the robot begins to contact with the environment, however, force oscillations may occur even if the optimal approach velocity is adopted, which may increase the settling time of the system, result in serious damage to the parts, and even make the otherwise stable controller unstable. To this end, based on nonlinear tracking differentiator (NTD) strategy, a novel force oscillations reduction method for robotic contact tasks is proposed in this article. To the best of our knowledge, this is the first time that NTD is used to reduce the force oscillations. The performance of the proposed method is evaluated by simulations and experiments, and the results demonstrate that the proposed method can effectively reduce the force oscillations, which provides a simple and useful solution for practical applications.
Concordance in Detecting Amyloid Positivity Between 18F-florbetaben and 18F-flutemetamol Amyloid PET Using Quantitative and Qualitative Assessments
Authors: Cho Soo Hyun , Choe Yeong Sim , Kim Young Ju , Lee Byungju , Kim Hee Jin , Jang Hyemin , Kim Jun Pyo , Jung Young Hee , Kim Soo-Jong , Kim Byeong C. , Farrar Gill , Na Duk L. , Moon Seung Hwan , Seo Sang Won 
Published: May 2020

Abstract
Background In the present study, the discrepancy in detecting amyloid beta (Aβ) positivity between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM) positron emission tomography (PET) was quantitatively and qualitatively assessed.Methods Paired FBB and FMM PET images were obtained on separate days from 107 participants. Three experts visually quantified the scans as positive or negative for Aβ deposition. Quantitative assessment was performed using global cortical standardized uptake value ratio (SUVR) with the whole cerebellum (WC) as a reference region.Results Inter-rater agreement was excellent for FBB (Fleiss k = 0.86) and FMM (Fleiss k = 0.78). The concordance rates between FBB and FMM were 94.4% (101/107) for visual assessment and 98.1% (105/107) for SUVR cut-off categorisation. Both FBB and FMM showed high agreement rates between visual assessment and SUVR positive or negative categorisation (93.5% in FBB and 91.2% in FMM). When the two ligands were compared based on SUVR cut-off categorisation as standard of truth, although not statistically significant, the false-positive rate (visual assessment-positive, SUVR-negative) was higher in FMM (9.1%) than in FBB (1.8%) (P = 0.13). In those cases, assessing uptakes in the lateral temporal cortex was often more problematic than in other regions in visual analysis, especially near the border with the occipital lobe.Conclusion Our findings suggested that both FBB and FMM had excellent agreement when used to quantitatively and qualitatively evaluate Aβ deposits, thus, combining amyloid PET data associated with the use of different ligands from multi-centers can be useful in future research.
Inflammation as a Driver of Vulvar Squamous Cell Carcinoma Progression.
Authors: Fatalska Agnieszka , Rusetska Natalia , Bakuła-Zalewska Elwira , Kowalik Artur , Zięba Sebastian , Wroblewska Agnieszka , Zalewski Kamil , Goryca Krzysztof , Domański Dominik , Kowalewska Magdalena 
Published: May 2020

Abstract
Background A knowledge on the biology of squamous cell vulvar carcinoma (VSCC) is limited. We aimed to identify protein markers of VSCC tumors stratifying patients by progression risk. Early stage VSCC tumors from patients who progressed (progVSCC) and from those who were disease-free (d-fVSCC) during follow-up, along with normal vulvar tissues were examined by mass spectrometry-based proteomics.Results In progVSCC vs d-fVSCC tumors, the immune response was the most over-represented Gene Ontology category for the identified DEPs. Interestingly, pathway profiling suggested bacterial infections to be linked to aggressive VSCC phenotypes. Differentially expressed proteins (DEPs) were verified in solid tissues and blood samples of patients with VSCC tumors and vulvar premalignant lesions. High Mobility Group AT-Hook 2 (HMGA2) and Proteinase 3 (PRTN3) were revealed as protein markers predicting VSCC progression.Conclusions HMGA2 and PRTN3 abundances are associated with aggressive VSCC phenotype, and hold promise as markers for patient stratification. It appears that vulvovaginal microflora disturbances trigger inflammatory response contributing to cancer progression.
Web Educativa 2.0
Authors: De la Torre Anibal 
Published: May 2020

Paralelamente al comienzo de la incorporación de las TICs a las prácticas educativas, se ha debatido bastante sobre las competencias tecnológicas que los docentes debían adquirir en sus diferentes procesos formativos. Sobre todo por ser necesarias determinadas destrezas en el uso y, sobre todo, en la generación de recursos para la Web.En los últimos meses estamos asistiendo a una amplia extensión del concepto de Web 2.0, cuya principal característica podría ser la sustitución del concepto de Web de lectura, por el de lectura-escritura. Multitud de herramientas están ayudando a que, los procesos productivos de información que se desarrollan en torno a la Red, se puedan poner en marcha sin casi ningún tipo de conocimiento técnico, y sin un excesivo gasto de tiempo. Por ello, poner en marcha actos educativos en torno a Internet (Web educativa 2.0), resulta hoy en día una tarea mucho más fácil desde el punto de vista de los recursos lógicos necesarios, con lo que podemos hacer prevalecer nuestro perfil docente sobre roles más cercanos al mundo de la Informática.AbstractParallelly to the beginning of the incorporation of the Technologies to the educative practice, many different opinions have arised on the technological skills that teachers have to acquire in their different learning processes. Above all, some determined skills are required in the use and, especially, in the production of resources for the Web.In the last months, we are attending a wide extension of the concept of Web 2,0, whose main characteristic could be the substitution of the concept of read Web, for the one of read-write Web. Multitude of tools are helping to, set the productive processes of information that are developed around the Web in motion; without the need of almost any technical knowledge, and without an excessive cost of time. For that reason, to start up educative acts around the Internet (Educative Web 2.0), is nowadays a much easier easy task from the point of view of necessary logical resources, with which we can make our educational profile prevail over rolls nearer the world of Computer science.
Elementos para el diseño de entornos educativos virtuales con base en el desarrollo de habilidades
Authors: Barroso Ramos Carlos 
Published: May 2020

El artículo presenta de manera sucinta el fundamento teórico, la estrategia seguida y los resultados obtenidos en un ejercicio de análisis efectuado para identificar el conjunto de habilidades cognitivas, que pueden ser reforzadas con el uso adecuado de cinco medios educativos basados en las Tecnologías de la Información y Comunicación (TIC). Para dicho análisis se consideró un contexto de aprendizaje específico, las características particulares de cada recurso y las condiciones en que fueron utilizados. Su intención última es aportar elementos de apoyo para la selección de medios en la integración de entornos educativos virtuales. AbstractThis article shows a general approach at conceptual fundaments, strategy and results obtains, about an analysis in relation with the development of cognitive skills among students that used five technological and didactic resources. The analysis strategy involves at specific educational environment, the own technical characteristics of resources and the way they were used. The proposal of this work is to offer specific and practical orientations to media selection that integrate educational virtual spaces.
Los medios de comunicación y la familia, ¿Un matrimonio de conveniencia?
Authors: Marín Díaz Verónica , Latorre Medina Mª José 
Published: May 2020

La relación entre los diferentes miembros de una misma familia, se ha visto siempre determinada por aquellas que mantiene con los diferentes medios de comunicación que les rodean. Hoy cuando los mass media viven a sus anchas en los hogares se hace necesario determinar el grado de relación entre la familia y estos, y si esa “relación afectiva” puede considerarse beneficiosa o no para ambas partes.AbstractThe relationship between the different members of a same family, it has been seen always determined by those that maintains with the different media that you surround. Today mass mean live to its broad in households is made necessary to determine the degree of relationship between the family and these, and if that "affective relationship" can be considered beneficial or not for both parts.
Aplicación del modelo b-learning en la asignatura “Modelos y Simulación” de las carreras de Sistemas de la FACENA- UNNE
Authors: Mariño Sonia Itatí , López María Victoria 
Published: May 2020

En este trabajo se describe una experiencia de b-learning desarrollada en la asignatura “Modelos y Simulación” de la FACENA-UNNE en el año 2005, y los resultados obtenidos de un relevamiento de datos aplicado en el aula, tendiente a conocer las posibilidades de acceso de los estudiantes a las TICs, para determinar el medio más conveniente para la distribución de material interactivo.AbstractThis article describes a b-learning experience developed at “Modelos y Simulación” subject of FACENA - Universidad Nacional del Nordeste (Corrientes, Argentina) in 2005 year. Also, the obtained results of a survey data applied in the classroom are included. It was applied to know the TICs access possibilities of the students, in order to determine the most advisable media for the distribution of interactive material.
La incidencia de las TICs en el fortalecimiento de hábitos y competencias para el estudio
Authors: Barroso Ramos Carlos 
Published: May 2020

Este artículo presenta los resultados de la investigación evaluativa realizada para determinar en qué medida la utilización de los medios soportados por las Tecnologías de la Información y Comunicación, fortalecieron el desarrollo de competencias para el estudio en los alumnos participantes en el Programa de Maestría en Administración y Desarrollo de la Educación, implementado en el Campus Virtual del Instituto Politécnico Nacional; y en consecuencia, conocer si se cumplieron las expectativas institucionales al respecto.AbstractThis article shows the results from the research made to determine how the means generated by Communication and Information Technologies, which were used during the Master Degree in Management and Education Development Program at the Instituto Politécnico Nacional Virtual Campus, reinforced the competences development among students; and to know if the institutional purposes were achieved.
Edutec en Latinoamérica
Authors: Dorrego Elena 
Published: May 2020

Este artículo describe la presencia de la Asociación Edutec en Latinoamérica, su colaboración con entidades e instituciones de distintos países latinoamericanos, así como la participación y organización en eventos internacionales. Se han revisado diferentes documentos impresos y digitales, así como testimonios, en los cuales se encuentra registrada, de manera dispersa, la historia de EDUTEC. AbstractThis article describes the presence of the Edutec Asociation in Latin America, the colaboration with organizations and intitutions of the several Latino American countries and the participation and organization of internacional events. For that, it has reviewed several printed and digital documents, the same way as testimonies which include the history of Edutec Asociation.
Preferencias en el uso de Internet, Televisión, Videoconsolas y Teléfonos móviles entre los menores de las Islas Baleares
Authors: Mut-Amengual Tomeu , Morey López Mercé 
Published: May 2020

El artículo que se presenta a continuación se basa en un estudio desarrollado por parte del grupo de investigación “Educación y ciudadanía” de la Universidad de las Islas Baleares sobre equipamientos y uso de las Tecnologías de la Información y la Comunicación entre los menores de las Islas Baleares con edades comprendidas entre los 6 y los 14 años. En el presente documento presentamos resultados parciales de la investigación, centrados en la penetración y uso de Internet frente a otros medios de comunicación e información y/o dispositivos de ocio, concretamente: la televisión, el móvil y la videoconsola. AbstractThe article that follows it is based on a study on equipment and use of Information Technologies and Communication among children of the Balearic Islands aged between 6 and 14 years developed by the research group "Education and Citizenship” adscript to the University of the Balearic Islands. In this paper we present partial results of a wider investigation, focuseed on the penetration and use of the Internet compared to other media and information and entertainment devices, including: television, mobile and video games.
Sistemas tutores inteligentes orientados a la enseñanza para la comprensión
Authors: Cataldi Zulma , Lage Fernando J. 
Published: May 2020

Un sistema tutor inteligente actúa como un tutor particular del estudiante, por lo que debe poseer libertad para actuar de acuerdo a las necesidades del estudiante. Por ese motivo se busca diseñar un sistema adaptable de acuerdo a los conocimientos previos y a la capacidad de evolución de cada estudiante y las concepciones epistemológicas que subyacen en las prácticas de enseñanza. Abstract An intelligent tutorial system acts like a particular tutor of the student, because it must own freedom to act according to the needs of the student. By that reason one looks for to design an adaptable system according to the previous knowledge and to the capacity of evolution of each student and the epistemological conceptions that underlie in the education practices.
Foros de discusión: un estudio de su aplicación en cursos de física universitaria
Authors: Aveleyra Ema , Chiabrando Laura 
Published: May 2020

Se estudian y categorizan las funciones de los foros de discusión en cursos de física básica con modalidad b-learning. Desde una perspectiva de investigación-acción, las preguntas que orientaron el estudio son: cómo fue utilizada esta vía de comunicación por estudiantes y docentes, y cómo se incorporó en estrategias de enseñanza. El análisis se realizó a partir de planificaciones, registros de los foros y entrevistas realizadas a estudiantes y docentes.AbstractThe features of discussion forums, in courses of basic physics with blended learning, are studied and categorized. From an action-research perspective, the questions guiding the study are: how this way of communication was used by students and teachers, and how it was joined to teaching strategies. The analysis was carried out from lesson planning, records of the forums and interviews with students and teachers.
Evolución del modelo docente: efectos de la incorporación del uso de una plataforma virtual, vídeos educativos y CD interactivos
Authors: Guzmán Parra Vanesa 
Published: May 2020

En este artículo se describen las conclusiones que se han obtenido en la evolución de las experiencias docentes realizadas en tres asignaturas diferentes relacionadas con la Organización de Empresas aplicándose y evaluándose tres modelos diferentes de docencia, experiencias que esperamos sirva de reflexión sobre cómo mejorar el proceso enseñanza-aprendizaje.El objetivo del último modelo puesto en práctica es aplicar una metodología de trabajo que complemente la formación presencial que reciben los alumnos, y demostrar por una parte que el uso de las nuevas tecnologías como elemento adicional de la enseñanza presencial puede mejorar el nivel de aprendizaje y la motivación de los alumnos. AbstractThis paper describes the results from an educational research which aim has been an experimental implementation of a several teaching models in three different subjetcs. The experience has revealed that innovations introduced in the didactic resources and methods, and in the evaluation system have allowed to advance towards a better educational model.The aim of the last model is applying a methodology in order to complement the traditional teaching model and to demonstrate that ICT are an important tool of the process of teaching-learning.