bluuebunny/crossref_metadata_2025_split huggingface dataset:
Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1
Authors: Zhang Kai , Yang Chun , Chang Lijia , Sakamoto Akemi , Suzuki Toru , Fujita Yuko , Qu Youge , Wang Siming , Pu Yaoyu , Tan Yunfei , Wang Xingming , Ishima Tamaki , Shirayama Yukihiko , Hatano Masahiko , Tanaka Kenji F. , Hashimoto Kenji 
Published: February 2020

AbstractIn rodent models of depression, (R)-ketamine has greater potency and longer-lasting antidepressant effects than (S)-ketamine; however, the precise molecular mechanisms underlying the antidepressant actions of (R)-ketamine remain unknown. Using RNA-sequencing analysis, we identified novel molecular targets that contribute to the different antidepressant effects of the two enantiomers. Either (R)-ketamine (10 mg/kg) or (S)-ketamine (10 mg/kg) was administered to susceptible mice after chronic social defeat stress (CSDS). RNA-sequencing analysis of prefrontal cortex (PFC) and subsequent GSEA (gene set enrichment analysis) revealed that transforming growth factor (TGF)-β signaling might contribute to the different antidepressant effects of the two enantiomers. (R)-ketamine, but not (S)-ketamine, ameliorated the reduced expressions of Tgfb1 and its receptors (Tgfbr1 and Tgfbr2) in the PFC and hippocampus of CSDS susceptible mice. Either pharmacological inhibitors (i.e., RepSox and SB431542) or neutralizing antibody of TGF-β1 blocked the antidepressant effects of (R)-ketamine in CSDS susceptible mice. Moreover, depletion of microglia by the colony-stimulating factor 1 receptor (CSF1R) inhibitor PLX3397 blocked the antidepressant effects of (R)-ketamine in CSDS susceptible mice. Similar to (R)-ketamine, the recombinant TGF-β1 elicited rapid and long-lasting antidepressant effects in animal models of depression. Our data implicate a novel microglial TGF-β1-dependent mechanism underlying the antidepressant effects of (R)-ketamine in rodents with depression-like phenotype. Moreover, TGF-β1 and its receptor agonists would likely constitute a novel rapid-acting and sustained antidepressant in humans.
Intermittent cafeteria diet identifies fecal microbiome changes as a predictor of spatial recognition memory impairment in female rats
Authors: Leigh Sarah-Jane , Kaakoush Nadeem O. , Bertoldo Michael J. , Westbrook R. Frederick , Morris Margaret J. 
Published: February 2020

AbstractExcessive consumption of diets high in saturated fat and sugar impairs short-term spatial recognition memory in both humans and rodents. Several studies have identified associations between the observed behavioral phenotype and diet-induced changes in adiposity, hippocampal gene expression of inflammatory and blood–brain barrier-related markers, and gut microbiome composition. However, the causal role of such variables in producing cognitive impairments remains unclear. As intermittent cafeteria diet access produces an intermediate phenotype, we contrasted continuous and intermittent diet access to identify specific changes in hippocampal gene expression and microbial species that underlie the cognitive impairment observed in rats fed continuous cafeteria diet. Female adult rats were fed either regular chow, continuous cafeteria diet, or intermittent cafeteria diet cycles (4 days regular chow and 3 days cafeteria) for 7 weeks (12 rats per group). Any cafeteria diet exposure affected metabolic health, hippocampal gene expression, and gut microbiota, but only continuous access impaired short-term spatial recognition memory. Multiple regression identified an operational taxonomic unit, from species Muribaculum intestinale, as a significant predictor of performance in the novel place recognition task. Thus, contrasting intermittent and continuous cafeteria diet exposure allowed us to identify specific changes in microbial species abundance and growth as potential underlying mechanisms relevant to diet-induced cognitive impairment.
Theory of Noise-Scaled Stability Bounds and Entanglement Rate Maximization in the Quantum Internet
Authors: Gyongyosi Laszlo , Imre Sandor 
Published: February 2020

AbstractCrucial problems of the quantum Internet are the derivation of stability properties of quantum repeaters and theory of entanglement rate maximization in an entangled network structure. The stability property of a quantum repeater entails that all incoming density matrices can be swapped with a target density matrix. The strong stability of a quantum repeater implies stable entanglement swapping with the boundness of stored density matrices in the quantum memory and the boundness of delays. Here, a theoretical framework of noise-scaled stability analysis and entanglement rate maximization is conceived for the quantum Internet. We define the term of entanglement swapping set that models the status of quantum memory of a quantum repeater with the stored density matrices. We determine the optimal entanglement swapping method that maximizes the entanglement rate of the quantum repeaters at the different entanglement swapping sets as function of the noise of the local memory and local operations. We prove the stability properties for non-complete entanglement swapping sets, complete entanglement swapping sets and perfect entanglement swapping sets. We prove the entanglement rates for the different entanglement swapping sets and noise levels. The results can be applied to the experimental quantum Internet.
DNA repair gene expression is associated with differential prognosis between HPV16 and HPV18 positive cervical cancer patients following radiation therapy
Authors: Sample Klarke M. 
Published: February 2020

AbstractCervical cancers are almost always induced by HPV infections, of which HPV16 and HPV18 are predominant. Cancers associated with these strains are induced through DNA repair factors and have a differential response to radiation therapy. Hence this study focuses on finding DNA repair gene expression differences in HPV16 and HPV18 positive cervical cancers after radiation therapy. A higher number of somatic mutations were observed in HPV16 positive cervical tumours for patients that were disease free when compared to those who recurred/progressed. Moreover, hierarchal clustering of RNAseq data from The Cancer Genome Atlas was conducted to identify groups of DNA repair genes associated with a differential prognosis for cervical cancer following postoperative radiation therapy. TP53BP1, MCM9 (at higher than mean levels), POLR2F and SIRT6 (at lower than mean levels), were associated with an increase in patients experiencing cervical cancer recurrence/progression following postoperative radiation therapy when HPV18 positive, but not HPV16 positive. The expression patterns of these genes provide an explanation for the higher rate of postoperative radiation therapy resistance associated with HPV18 positive cervical cancer patients. Therefore, HPV18 positive cervical tumours may be more likely retain a greater non-homologous end joining and homologous recombination pathway activity, which could dampen the effect of postoperative radiation therapy. Moreover, greater susceptibility to postoperative radiation therapy could be caused by the reliance of cervical cancer cells upon the single-strand annealing and nucleotide excision pathways for repair of DNA damage.
In vitro replicative fitness of early Transmitted founder HIV-1 variants and sensitivity to Interferon alpha
Authors: Ashokkumar Manickam , Sonawane Aanand , Sperk Maike , Tripathy Srikanth P. , Neogi Ujjwal , Hanna Luke Elizabeth 
Published: February 2020

AbstractType I interferons, particularly interferon-alpha (IFN-α), play a vital role in the host's anti-viral defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the IFN-α response for its replication, spread, and pathogenic function. In this study, we attempted to determine IFN-α susceptibility and productivity of infectious transmitted/founder (TF) (n = 8) and non-transmitted (NT) viruses (n = 8) derived from HIV-1 infected infants. Independent experiments were carried out to determine IFN-α resistance, replication fitness, and viral productivity in CD4+T cells over a short period.In vitrostudies showed that TF viruses were resistant to IFN-α during the very near moment of transmission, but in the subsequent time points, they became susceptible to IFN-α. We did not observe much difference in replicative fitness of the TF viruses in cultures treated with and without IFN-α, but the difference was significant in the case of NT viruses obtained from the same individual. Despite increased susceptibility to IFN-α, NT viruses produced more viral particles than TF viruses. Similar results were also obtained in cultures treated with maraviroc (MVC). The study identified unique characteristics of TF viruses thus prompting further investigation into virus-host interaction occurring during the early stages of HIV infection.
Physical Layer Security in Multimode Fiber Optical Networks
Authors: Rothe Stefan , Koukourakis Nektarios , Radner Hannes , Lonnstrom Andrew , Jorswieck Eduard , Czarske Jürgen W. 
Published: February 2020

AbstractThe light propagation through a multimode fiber is used to increase information security during data transmission without the need for cryptographic approaches. The use of an inverse precoding method in a multimode fiber-optic communication network is based on mode-dependent losses on the physical layer. This leads to an asymmetry between legitimate (Bob) and illegitimate (Eve) recipients of messages, resulting in significant SNR advantage for Bob. In combination with dynamic mode channel changes, there are defined hurdles for Eve to reconstruct a sent message even in a worst-case scenario in which she knows the channel completely. This is the first time that physical layer security has been investigated in a fiber optical network based on measured transmission matrices. The results show that messages can be sent securely using traditional communication techniques. The technology introduced is a step towards the development of cyber physical systems with increased security.
A facile chemical synthesis of CuxNi(1−x)Fe2O4 nanoparticles as a nonprecious ferrite material for electrocatalytic oxidation of acetaldehyde
Authors: Khalaf Mai M. , Abd El-Lateef Hany M. , Alnajjar Ahmed O. , Mohamed Ibrahim M. A. 
Published: February 2020

AbstractIn the present work, Cu-doped nickel ferrite (CuxNi(1−x)Fe2O4) nanoparticles (CuNFNPs) were chemically fabricated by adding citric acid as a capping agent followed by combustion and calcination for acetaldehyde oxidation reaction (AOR) in KOH electrolytes. The as-prepared CuNFNPs were studied in terms of Fourier-transform infrared spectroscopy (FT-IR), Transmission electron microscopy (TEM), Field emission scanning electron microscope (FE-SEM), Energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD) and Brunauer-Emmett-Teller (BET) specific surface area analyses. The morphology of CuNFNPs has sponges-structure containing irregular pores. Additionally, XRD analysis indicated that the prepared CuNFNPs have a cubic-crystals ferrite without the existence of impurities and the crystal size around 20.2 nm. The electrooxidation of acetaldehyde by the presented CuNFNPs was investigated using cyclic voltammetry (CV), chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS) in −OH media. Furthermore, the effects of −OH and acetaldehyde on the electrocatalytic performance were studied with and without Cu-doping in addition to EIS and CA studies which confirm the high-performance of CuNFNPs as an electrocatalyst for AOR.
Giant thermal expansion of a two-dimensional supramolecular network triggered by alkyl chain motion
Authors: Scherb Sebastian , Hinaut Antoine , Pawlak Rémy , Vilhena J. G. , Liu Yi , Freund Sara , Liu Zhao , Feng Xinliang , Müllen Klaus , Glatzel Thilo , Narita Akimitsu , Meyer Ernst 
Published: February 2020

AbstractThermal expansion, the response in shape, area or volume of a solid with heat, is usually large in molecular materials compared to their inorganic counterparts. Resulting from the intrinsic molecule flexibility, conformational changes or variable intermolecular interactions, the exact interplay between these mechanisms is however poorly understood down to the molecular level. Here, we investigate the structural variations of a two-dimensional supramolecular network on Au(111) consisting of shape persistent polyphenylene molecules equipped with peripheral dodecyl chains. By comparing high-resolution scanning probe microscopy and molecular dynamics simulations obtained at 5 and 300 K, we determine the thermal expansion coefficient of the assembly of 980 ± 110 × 10−6 K−1, twice larger than other molecular systems hitherto reported in the literature, and two orders of magnitude larger than conventional materials. This giant positive expansion originates from the increased mobility of the dodecyl chains with temperature that determine the intermolecular interactions and the network spacing.
Obesity and adiposity: the culprit of dietary protein efficacy
Authors: El-Mallah Carla , Obeid Omar 
Published: February 2020

AbstractObesity and increased body adiposity have been alarmingly increasing over the past decades and have been linked to a rise in food intake. Many dietary restrictive approaches aiming at reducing weight have resulted in contradictory results. Additionally, some policies to reduce sugar or fat intake were not able to decrease the surge of obesity. This suggests that food intake is controlled by a physiological mechanism and that any behavioural change only leads to a short-term success. Several hypotheses have been postulated, and many of them have been rejected due to some limitations and exceptions. The present review aims at presenting a new theory behind the regulation of energy intake, therefore providing an eye-opening field for energy balance and a potential strategy for obesity management.
Erst Rheuma, dann Osteoporose – aktuelle Empfehlungen aus sport- und bewegungstherapeutischer Sicht
Authors: Dreher Matthias , Liebscher Robert , Schwarting Andreas 
Published: February 2020

ZusammenfassungDie gesundheitlich positiven Wirkungsweisen von körperlicher Aktivität und körperlichem Training sind für viele Erkrankungsbilder wissenschaftlich weitestgehend belegt. Auch bei entzündlich-rheumatischen Erkrankungen und der Osteoporose wird von positiven Effekten auf das Krankheitsbild und deren potenziellen Komorbiditäten durch die Sport- und Bewegungstherapie ausgegangen. Ihre Wirkungsweisen werden in dieser Übersichtsarbeit näher betrachtet.Auf Basis einer Literaturrecherche wurden randomisierte kontrollierte Studien (RCT), nicht-RCT-Studien, systematische Übersichtsarbeiten und Empfehlungen von Fachgesellschaften einbezogen.Die Ausbildung einer Osteoporose ist eine häufig auftretende Komorbidität der medikamentösen Therapie bei entzündlich-rheumatischen Erkrankungsbildern. Dies wird durch das Manifestationsalter der entzündlich-rheumatischen Erkrankungen und den Bewegungsmangel bei bereits Erkrankten unterstützt. Körperliche Aktivität und Training zeigen eine positive Wirkung, sowohl auf entzündlich-rheumatische Erkrankungsbilder als auch auf das Erkrankungsbild der Osteoporose und darüber hinaus auf deren Komorbiditäten. Zudem existieren auf Basis der Bewegungs- und Trainingsempfehlungen des American College of Sports Medicine (ACSM) und der American Heart Association (AHA) Ansatzpunkte, die durch die European League Against Rheumatism (EULAR) adaptiert wurden, um Intensität, Dauer und Umfänge in der Prävention und Rehabilitation zu steuern.Die Steigerung der körperlichen Aktivität und das regelmäßige körperliche Training sollten grundlegende additive Bestandteile der Therapie bei entzündlich-rheumatischen Erkrankungen und der Osteoporose sein. In einzelnen Subaspekten ist die Studienlage sehr heterogen, vor allem bei entzündlich-rheumatischen Erkrankungen. Hierzu bedarf es weiterer Forschung.
Wo sich Wissenschaft und Praxis treffen: anwendungsorientierte Forschung in Bewegungstherapie und Gesundheitssport – eine Einführung
Authors: Schaller Andrea , Peters Stefan 
Published: February 2020

ZusammenfassungDer vorliegende Beitrag dient als Einführung der Reihe „Wo sich Wissenschaft und Praxis treffen“. In diesem Rahmen werden künftig in regelmäßigen Abständen die Grundlagen wissenschaftlicher Methoden für Praktiker und Nachwuchswissenschaftler erläutert. Auf diese Weise soll für wesentliche Aspekte des wissenschaftlichen Arbeitens sensibilisiert werden und die Zusammenarbeit von Wissenschaft und Praxis in der anwendungsorientierten Forschung verbessert werden. Im ersten Beitrag werden die Relevanz von Evaluationen in der bewegungsbezogenen Praxis und im Rahmen dessen der Stellenwert der Theorie und der Forschungsfrage sowie mögliche empirische Studientypen vorgestellt.
Stress und Erschöpfung – Die Leistung optimieren mit Āyurveda
Authors: Nagersheth Kalyani 
Published: February 2020

SummaryErschöpfungszustände sind mit ayurvedischer Medizin sehr gut behandelbar. An erster Stelle stehen Lebensstilinterventionen auf Basis der jeweiligen Konstitution. Eine Tagesroutine, die Entspannung und Ausgleich integriert, z.B. mit Atemübungen und Sport, konstitutionsgerechte Ernährung, Kräuter, die Stresssymptome reduzieren sowie äußerliche Anwendungen wie Öleinreibungen lassen Körper und Psyche wieder zur Ruhe kommen. Ayurveda beinhaltet zudem ethische Grundsätze, die für Psychohygiene sorgen sowie der mentalen Gesundheit und Stabilität dienen. Darin geht es v.a. um Achtsamkeit mit sich selbst und anderen.Anhand eines Falls aus der Praxis werden das mögliche Vorgehen und die möglichen Erfolge skizziert.
Keratitis solaris – Prävention, Diagnostik und Therapie der UV-bedingten Augenerkrankung
Authors: Brandl Michaela 
Published: February 2020

ZUSAMMENFASSUNGUV-Strahlung ist ein großes Risiko für Augenschäden. Die Erkrankung Keratitis solaris, auch bekannt als „Schneeblindheit“ oder Keratitis photoelectrica, wird in diesem Beitrag vorgestellt. Sie lässt sich behandeln, kann jedoch starke Schmerzen verursachen und Erkrankte durch eingeschränkte Sicht in gefährliche Situationen bringen. Fester Bestandteil jeder Tour sollte deshalb eine geeignete Sonnenbrille sein, die auch weitere UV-bedingte Augenerkrankungen verhindern kann.
POLKA – ein Modellvorhaben zur Prävention in stationären Pflegeeinrichtungen
Authors: Polka Autorenteam 
Published: February 2020

ZusammenfassungDie Gesetzeslage zur Prävention in Pflegeeinrichtungen ist eindeutig, aber sehr komplex. Die anwenderorientierte Umsetzung zur Stärkung gesundheitsförderlicher Ressourcen in Pflegeeinrichtungen ist mehrdimensional.Leistungsträger sind zum trägerübergreifenden Handeln aufgefordert. Zudem müssen Leistungsträger aus verschiedenen Sektoren – auch in der Finanzierung – interagieren (z. B. die Pflegeversicherung mit den Bereichen Prävention und Betriebliches Gesundheitsmanagement der Krankenversicherung). Leistungserbringer / Pflegeeinrichtungen müssen die Bereitschaft entwickeln, trotz bestehender hoher Anforderungen in der Pflege, innovative Interventionen mitzutragen, zu entwickeln, zu erproben und zu integrieren. Das ist nur in einem partizipativen Ansatz möglich.Die Zielgruppe der Pflegebedürftigen ist heterogen – auch innerhalb des gleichen Pflegegrades. Letztlich müssen im Setting Pflegeeinrichtung mehrere Zielgruppen berücksichtigt werden: Pflegefachkräfte (einschließlich der Pflegedienstleitungen und Heimleitungen), Pflegebedürftige, Angehörige der Pflegebedürftigen. Zu einer vollumfänglichen Gesundheitsförderung sollten zudem auch kommunale Rahmenbedingungen sowie die Pflegeausbildung berücksichtigt werden. Zudem sind qualitätssichernde Strukturen, Prozesse und Ergebnisse zur Optimierung in einem Qualitätsmanagement-System abzubilden, um Prävention als ein Leitmotiv der Pflegeeinrichtung mit Leben zu füllen.In der Umsetzung des § 5 SGB XI gibt es derzeit einige punktuelle Ansätze, Konzepte und Projekte. Das in diesem Artikel vorgestellte Modellvorhaben beansprucht einem mehrdimensionalen Zugang zum Thema. Der Artikel vermittelt interessierten Lesern, wie das Modellvorhaben in der einjährigen Vorlaufphase entwickelt wurde und konzeptionell geplant ist. Erste Planungsschritte und Vorhabensbeschreibungen werden vorgestellt.
Studyability als Ziel des Gesundheitsmanagements für Studierende
Authors: Huber Gerhard , Kellner Mona 
Published: February 2020

ZusammenfassungVerschiedene epidemiologische Befragungen erhoben in den letzten Jahren Daten zum Gesundheitszustand der Studierenden in der Bundesrepublik. Obgleich die Ergebnisse eine vergleichsweise gesunde Statusgruppe vermuten lassen, wird bei genauerer Betrachtung deutlich, dass auch unter den Studierenden verschieden vulnerable Gruppen sind, für die die Konzeption eines maßgeschneiderten Gesundheitsmanagements notwendig ist. Diese Konzeption orientiert sich dabei am House of Workability [1]. Im Rahmen eines Forschungsprojektes wird dieses Modell als Basis für die Weiterentwicklung eines „House of Studyability“ genutzt. Dieses Vorgehen hat Vorteile sowohl für die Strukturierung der bisherigen Interventionen als auch für die Identifikation fehlender Gesundheitsförderungsansätze.
Dietary pattern of sugar canne cutters in a city of the northwest of Sao Paulo
Authors: Piacentin Alfredo Bosquero , Nogueira Heitor Vieira , Pedigoni Henrique Garcia , Guardia Renan Cenize , Filho Durval Ribas 
Published: February 2020

ABSTRACT
Background: Sugar cane used for alcohol production is a very important economic activity in rural areas of Sao Paulo state. There is still a population of workers that are essential for cutting the plants. Therefore, the investigation of their eating habits, and the quantification of nutrient intake might help the government to develop public health and nutrition intervention programs.
Methods: This was a descriptive, observational, and transversal study. The instrument used on the study was the 24-hour dietary recall applied to 71 sugar cane cutters, which was fulfilled by the researchers at the farm. Everything ingested by the workers was registered and split into portions, in every meal. Subsequently, the food ingested was analyzed as to quantities and compared to the traditional Brazilian feeding pyramid.
Results: Eleven percent of the workers had 6 daily meals, prevailing 4 to 5 meals a day. Regarding the food groups, the number of portions (mean ± SD) were: bread, rice, pasta and potato, 8±2; fruits 1±1,2; vegetables 1,33±; beans 3,6±1,6; meat and eggs 4,3±1,8; milk cheese and yogurt 0,92±0,9; sugar and sweets 0,64±1,16; oil and fat 0,79±0,51
Conclusions: Based on the present data, it was possible to conclude that rural workers that work on sugar cane crops have an inadequate dietary patter with reduced food variety, consisting basically of bread, rice, beans and cattle meat.
Cereais integrais na alimentação infantil
Authors: de Almeida Carlos Alberto Nogueira , Fernandes Geórgia de Castro 
Published: February 2020

RESUMOO presente artigo discute os conceitos básicos a respeito dos cereais integrais e descreve os benefícios à saúde reconhecidos pela ciência associados ao seu consumo. Apresenta também informações sobre fontes dietéticas, rotulagem e teor de cereais integrais nos alimentos.
A importância do porcionamento na alimentação balanceada
Authors: de Almeida Carlos Alberto Nogueira , Fernandes Geórgia de Castro 
Published: February 2020

RESUMOO artigo discute a importância da utilização do conceito de porções para a obtenção de uma alimentação saudável, incluindo informação básicas sobre os guias alimentares e sua aplicação para o planejamento de cardápios.