bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood–Brain Barrier Integrity
Authors: Bai Ying , Zhang Yuan , Han Bing , Yang Li , Chen Xufeng , Huang Rongrong , Wu Fangfang , Chao Jie , Liu Pei , Hu Gang , Zhang John H. , Yao Honghong 
Published: September 2020

Circular RNAs (circRNAs) are highly expressed in the CNS and regulate physiological and pathophysiological processes. However, the potential role of circRNAs in stroke remains largely unknown. Here, we show that the circRNA DLGAP4 (circDLGAP4) functions as an endogenous microRNA-143 (miR-143) sponge to inhibit miR-143 activity, resulting in the inhibition of homologous to the E6-AP C-terminal domain E3 ubiquitin protein ligase 1 expression. circDLGAP4 levels were significantly decreased in the plasma of acute ischemic stroke patients (13 females and 13 males) and in a mouse stroke model. Upregulation of circDLGAP4 expression significantly attenuated neurological deficits and decreased infarct areas and blood–brain barrier damage in the transient middle cerebral artery occlusion mouse stroke model. Endothelial-mesenchymal transition contributes to blood–brain barrier disruption and circDLGAP4 overexpression significantly inhibited endothelial-mesenchymal transition by regulating tight junction protein and mesenchymal cell marker expression. Together, the results of our study are illustrative of the involvement of circDLGAP4 and its coupling mechanism in cerebral ischemia, providing translational evidence that circDLGAP4 serves as a novel therapeutic target for acute cerebrovascular protection.SIGNIFICANCE STATEMENTCircular RNAs (circRNAs) are involved in the regulation of physiological and pathophysiological processes. However, whether circRNAs are involved in ischemic injury, particularly cerebrovascular disorders, remains largely unknown. Here, we demonstrate a critical role for circular RNA DLGAP4 (circDLGAP4), a novel circular RNA originally identified as a sponge for microRNA-143 (miR-143), in ischemic stroke outcomes. Overexpression of circDLGAP4 significantly attenuated neurological deficits and decreased infarct areas and blood–brain barrier damage in the transient middle cerebral artery occlusion mouse stroke model. To our knowledge, this is the first report describing the efficacy of circRNA injection in an ischemic stroke model. Our investigation suggests that circDLGAP4 may serve as a novel therapeutic target for acute ischemic injury.
Clinical and genetic characteristics of Dutch children with central congenital hypothyroidism, early detected by neonatal screening
Authors: Naafs J C , Verkerk P H , Fliers E , van Trotsenburg A S P , Zwaveling-Soonawala N 
Published: September 2020

Objective
To evaluate clinical characteristics of patients with central congenital hypothyroidism (CH), detected in the Dutch neonatal screening program. This included patients with isolated central CH but the majority have multiple pituitary hormone deficiencies (MPHD).

Design
Nationwide, cross-sectional study.

Methods
Data was collected on clinical characteristics, endocrine tests and neuroimaging of central CH patients, detected by the Dutch neonatal screening and born between 1 January 1995 and 1 January 2015. Height and pubertal status were assessed during a study visit. Isolated central CH patients without a confirmed genetic diagnosis were offered genetic (re-)testing.

Results
During the 20-year period 154 central CH patients were detected (incidence of permanent central CH 1:25 642). After excluding deceased (15), severe syndromic (7) and transient patients (6), 92 of 126 eligible patients were included (57 MPHD; 79% male). Sixty-one patients (50 MPHD) had been hospitalized before screening results were reported, but central CH was diagnosed on clinical grounds in only three of them (5%). MRI abnormalities consistent with pituitary stalk interruption syndrome were seen in 50 (93%) MPHD patients. Among isolated central CH patients, 27 (84%) had an IGSF1, TBL1X or IRS4 gene variant (53, 16 and 16%, respectively).

Conclusion
Many patients with central CH have neonatal health problems, especially MPHD patients. Despite hospital admission of two-thirds of patients, almost none were diagnosed clinically, but only after the notification of an abnormal screening result was received. This indicates that central CH, especially if isolated, is an easily missed clinical diagnosis.
Quo vadis Rorschach-teszt? A Rorschach-próba múltja, jelene, krízisei, megújulása és jövője
Authors: Császár-Nagy Noémi 
Published: September 2020

Célkitűzés: A tanulmány a Rorschach projektív személyiségvizsgáló eljárás történeti nyomvonalán haladva a teszt fejlődésének, kríziseinek és megújulásának fázisait teszi követhetővé.Módszertan: Alapvető forrásmunkák, monográfiák, történeti és szakirodalmi tanulmányokon alapuló gyűjtés adatainak rendezése, történeti és fejlődési korszakokra tagolása.Eredmények: A teszt szakmatörténeti fejlődési útját hat szakaszra tagolva ismertetjük az ötlettől a megvalósulásig: történések Hermann Rorschach haláláig (1. szakasz); a teszt sorsa a Rorschach halála utáni évtizedben (1923-1936) (2. szakasz); a teszt súlypontjának átkerülése az USA-ba (3. szakasz); a második világháborútól a hetvenes évekig terjedő időszak (1941-1970), a teszt fénykora és alkonya (4. szakasz); a teszt újjászületése, a szintézisteremtő John Exner munkássága (5. szakasz), valamint: támadások tüzében és az új R-PAS teszt születése (6. szakasz).Következtetések: A fejlődési út a teszt keletkezésétől kezdve mindmáig konfliktushordozó. A kauzális gondolkodás fegyelme, a tesztológia pszichometrikus követelményei, valamint az életszerű közelítés, a viselkedés átfogó és intuitív értelmezési módja közt feszülő, megújuló ellentéteket tárja fel. A konfliktus kezelésének történeti jellegzetessége a hegeli „megszüntetve megőrzés" (Aufheben), a régibe ágyazódó, megújuló módszertanok születése. Ezt tükrözi a Rorschach-teszt története is.Objective: This study makes the phases of the test's development, crises and renewal traceable by means of the historical trajectory of the Rorschach Projective Personality Examination Procedure.Methodology: An analysis of data collected from essential sources, including monographs as well as historical and literary studies, broken down into the historical periods of the test's development.Results: The historical trajectory of the test is described in six phases: From the idea to its realisation - the events prior to Hermann Rorschach's death (Phase 1); The fate of the test in the decade after Rorschach's death (1923-36) (Phase 2); The shift in focus to the United States (Phase 3); The period from World War II to the 1970s (1941-1970), The golden age and decline of the test (Phase 4); The rebirth of the test and the work of the synthesiser John Exner (Phase 5); and The test under attack and the birth of the new R-PAS test (Phase 6).Conclusions: The test's path of development, from its genesis up to the present day, has been marked by conflict. This reveals the tense and on-going contradictions between the discipline of causal thinking, the psychometric requirements of testing and a realistic, comprehensive and intuitive approach to interpreting behaviour. A historical feature of conflict management in Hegelian terms is 'sublation ' (Aufheben), or the renewal of methodologies that are embedded in the past. This is also reflected in the history of the Rorschach test.
Az észlelt társas támogatás összefüggéseinek vizsgálati lehetőségei a PRISM-D rajzteszt segítségével kórházi kezelés alatt álló súlyos betegek körében
Authors: Sándor Zita , Látos Melinda , Csabai Márta 
Published: September 2020

Absztrakt:
Bevezetés: Kórházi betegek körében a betegség okozta változások
miatt a társas kapcsolatok átrendeződhetnek, erősödhetnek, de akár gyengülhetnek
is. Ezen változások mérése, a szubjektíve megélt társas támogatás mértékének,
elérhetőségének vagy akár az észlelt izolációnak a kimutatása fontos feladat,
ugyanis ezen dimenziók összefüggnek a gyógyulási mutatókkal.
Célkitűzés: A kutatás célja annak bemutatása, hogy az
általunk fejlesztett PRISM-D rajzteszt hogyan alkalmazható az észlelt társas
támogatás mérésére. További célkitűzés a teszten mért társas támogatás
mutatóinak és a depresszió-, valamint a szorongásszint közötti kapcsolatnak a
vizsgálata súlyos betegek esetében. Módszer: 194 súlyos,
kórházi kezelés alatt álló beteg (daganatos, műtéti beavatkozást igénylő
gyomor-bél rendszeri betegségben és krónikus veseelégtelenségben szenvedő
betegek) esetében a PRISM-D rajzteszt, a STAI- és BDI-tesztek felvétele kórházi
osztályokon. Eredmények: A vizsgálati személyek többsége
megjelenítette a rajzteszten a társas támogatást (95,7%), jelentős hányaduk több
körrel (64,0%) és nagyobbnak, mint a betegséget szimbolizáló kör (71,2%). Azok a
személyek, akik nem jelenítettek meg egyetlen társas támogató személyt sem,
szignifikánsan magasabb szorongásszintet éltek meg (STAI-S: p = 0,040, df = 181;
STAI-T: p = 0,005, df = 153). A térbeli elhelyezkedést tekintve azok a betegek,
akik az Ént és a betegséget szimbolizáló kör közé helyezték el a társas
támogatást, alacsonyabb szintű szorongást és depresszív tüneteket éltek meg,
mint akik a betegséget rajzolták közelebb, a társas támogatást távolabb (STAI-S:
p = 0,016, df = 91; BDI: p = 0,027, df = 142). Következtetés:
Eredményeink szerint a PRISM-D rajzteszt alkalmas az észlelt társas támogatás
vizsgálatára, az Énhez és a betegséghez viszonyított szubjektív jelentőségének
és észlelt közelségének mérésére, továbbá az észlelt szociális izoláció
detektálására. Gyors, egyszerű mérőeszközként nagymértékben segítheti kórházi
osztályokon a szűrést és a terápiás munkát. Orv Hetil. 2020; 161(39):
1688–1696.
Fikih Mangrove: Formulasi Fikih Lingkungan Pesisir Perspektif Eko-Syariah
Authors: Mufid Moh. 
Published: September 2020

Abstract: This article is a study of mangrove management in eco-sharia perspective. Conservation efforts in the coastal areas must be constructed based on religious values â€‹â€‹so that it is expected to create a collective attitude of environmental awareness among coastal communities. Eco-sharia as an approach can provide a new paradigm related to the preservation of the coastal environment with anthropo-cosmic insights. The concept of eco-ecology and ecosystem can also provide a comprehensive understanding in the effort to support the existence of coastal environment jurisprudence. Normatively, the perspective of Islamic jurisprudence on mangroves preservation can be built through an in-depth understanding of Islamic recommendations in rehabilitating mangrove habitats in coastal area; Procedure of mangrove land conversion based on consideration of principle of benefit; Thus, it is urged that local governments to issue regulations to manage mangrove preservation in a sustainable manner.
Abstrak: Artikel ini merupakan kajian pengelolaan mangrove dalam perspektif eko-syariah. Upaya pelestarian di wilayah pesisir harus dikonstruksi berbasis nilai-nilai religius sehingga diharapkan mampu melahirkan sikap kesadaran lingkungan secara kolektif di kalangan masyarakat pesisir. Eko-syariah sebagai suatu pendekatan dapat memberikan paradigma baru terkait pelestarian lingkungan pesisir dengan wawasan antropokosmis. Konsep ekoteologi dan ekosofi juga dapat memberikan pemahaman yang komprehensif dalam upaya mendukung eksistensi fikih lingkungan pesisir. Secara normatif, fikih mangrove dapat dibangun melalui pemahaman secara mendalam tentang anjuran Islam dalam merehabilitasi habitat mangrove di pesisir; prosedur alih fungsi lahan mangrove berdasarkan pertimbangan asas manfaat-mafsadat; keniscayaan pemerintah daerah menerbitkan regulasi untuk mengatur pengelolaan mangrove secara berkelanjutan.
Hegemoni Sosial dan Politik Identitas Putra Daerah Jambi
Authors: Ulum Bahrul , Jannah St. Raudhatul , Arifullah Mohd. 
Published: September 2020

Abstract: The article describes social hegemony and political domination of local people identity in Jambi. As elsewhere in Indonesia, Jambi is composed of locals and migrants. There is apparent hegemonic contestation between locals and migrants in Jambi. Migrants seems well-fit in Jambi and play significant role in urban context. In contrast, with exception of people of Kerinci and Malayu Jambi, locals seems to be marginalized especially people from Anak Dalam tribe who still hold on their primordial tradition. In political realm, locality and primordial sentiments still play major role during regional political election. The structure and use of politics of identity in Jambi is manifested by the occurrence of conflict of interest and sectoral ego which employs three main power instruments; bureaucracy, religion ad law.
Abstrak: Artikel ini menggambarkan hegemoni sosial dan dominasi politik identitas putra daerah di Provinsi Jambi. Masyarakat Jambi terdiri dari warga pribumi dan pendatang. Hegemoni di masyarakat Jambi antara penduduk pribumi dan pendatang, secara kasat mata, kalangan pendatang tidak mengalami masalah sosial, penduduk pendatang justru memainkan peran penting di pusat-pusat perkotaan, sementara kebanyakan penduduk pribumi, kecuali Suku Kerinci dan Suku Melayu Jambi, menempati posisi yang agak termarjinalkan, terutama Suku Anak Dalam yang masih terlihat enggan untuk mengakomodir kemajuan dalam kehidupan mereka yang lestari. Dalam dimensi politik, isu kedaerahan ataupun sentimen primordialisme dalam kehidupan masyarakat Jambi sangat kentara. Bangunan pola operasionalisasi politik identitas dapat ditemukan pada berbagai realitas yang terjadi pada masyarakat Jambi yang ditunjukkan dari banyaknya benturan kepentingan (conflic of interest) dan fenomena ego sektoral dengan menggunakan tiga instrumen kuasa utama, yaitu (a) kuasa pemerintahan; (b) kuasa agama; (c) kuasa hukum.
Peraturan Daerah Bermuatan Syariat Islam Ditinjau Dari Prinsip Demokrasi Konstitusional
Authors: Fuqoha Fuqoha 
Published: September 2020

Abstrak: Dalam penyelenggaraan pemerintahan daerah, perlu aturan hukum sebagai landasan dalam melaksanakan segala urusan pemerintahan daerah. Bentuk pengaturan dalam pemerintahan daerah ialah peraturan daerah. Konsepsi demokrasi memberikan kewenangan pada setiap daerah untuk membentuk dan memberlakukan peraturan daerah sesuai dengan nilai-nilai kearifan lokal. Di antara nilai-nilai kearifan lokal dalam muatan peraturan daerah adalah syariat Islam. Tujuan dibentuknya peraturan daerah di antaranya adalah untuk memelihara ketertiban hukum (rechtsorde) sesuai dengan cita atau kekhasan masyarakat daerah. Ditinjau dari prinsip demokrasi konstitusional, peraturan daerah bermuatan syariat Islam merupakan hak bagi setiap daerah dan masyarakat daerah sesuai dengan kesepakatan masyarakat (resultante) selama tidak bertentangan dengan konstitusi. Muatan syariat Islam dalam peraturan daerah dibatasi oleh konstitusi dalam prinsip demokrasi konstitusional. Kebebasan dalam memberikan muatan dalam suatu peraturan daerah, menunjukkan konsep demokrasi yang dianut bangsa Indonesia terlaksana sesuai dengan ketetapan pada konstitusi, sehingga pemberlakuan peraturan daerah bermuatan syariat Islam merupakan cita demokrasi dan bukan merupakan ancaman bagi demokrasi.
Kata Kunci: Peraturan Daerah, syariat Islam, demokrasi konstitusional
TahqÃ®q al-ManÃ¢th dalam Pembaruan Hukum Kewarisan Islam di Indonesia
Authors: Darmawan Darmawan 
Published: September 2020

Abstract: TahqÃ®q al-manÃ¢th is a process and effort to find law in Islamic lega tradition. It consists of three phases: (1) istinbÃ¢t min al-nushÃ»sh, extracting law from textual sources using literal interpretation, (2) idrÃ¢k al-wÃ¢qi', full comprehension of real legal cases by employing all necessary disciplines, and (3) tanzÃ®l al-ahkÃ¢m â€˜alÃ¢ al-wÃ¢qi', a step to apply law to cases using maqÃ¢shid as analytical instrument. Formulation of re-actualization of Islamic inheritance law in Indonesia is conducted by takhyir, which electively select appropriate legal opinion for implementation, talfiq, which is combining opinions of various schools of law, and takyif, which is adaptation and accommodation of external aspects that includes consideration to local custom in the formation of re-actualization of Islamic inheritance law in Indonesia.
Key words: TahqÃ®q al-manÃ¢th, re-actualization, Islamic inheritance law
Tanggung Gugat Pejabat Pembuat Akta Tanah Atas Keterlambatan Pendaftaran Akta Pemberian Hak Tanggungan Secara Online di Kantor Pertanahan
Authors: Zakiyyah Fatimah 
Published: September 2020

Jurnal berjudul Analisis Tanggung Gugat Pejabat Pembuat Akta Tanah Atas Keterlambatan Pendaftaran Akta Pemberian Hak Tanggungan Secara Online Di Kantor Pertanahan, dengan permasalahan yaitu ratio decidendi hakim yang menolak permohonan kasasi pemohon dalam putusan Mahkamah Agung Nomor 1563 K/Pdt/2010 tersebut dan akibat hukum bagi kreditor atas keterlambatan pendaftaran APHT oleh PPAT secara online ke Kantor Pertanahan untuk terbitnya sertipikat hak tanggungan, diperoleh suatu kesimpulan bahwa: Ratio decidendi putusan Mahkamah Agung Nomor 1563 K/PDT/2010, yang menolak dalil-dalil penggugat (Wati Rachmawati dan Herizal Febriansyah) mengenai cacat hukum APHT karena PPAT mengirimkan berkas APHT lebih dari 7 (tujuh) hari setelah berkas ditandatangani bertentangan dengan ketentuan pasal 13 UUHT. Namun Mahkamah Agung dalam putusannya menolak dalil-dalil kasasi dari Wati Rachmawati dan Herizal Febriansyah dengan pertimbangan pemohon kasasi tidak dapat membuktikan dalil-dalilnya, yang berarti bahwa jika pemohon kasasi dapat membuktikan keterlambatan pengiriman berkas dalam APHT, maka gugatan dikabulkan, karena yang dibebani pembuktian bukan Wati Rachmawati dan Herizal Febriansyah, melainkan PPAT yang membuat APHT
PPAT yang terlambat mengirimkan akta pemberian hak tanggungan dapat dikatakan melakukan perbuatan melanggar hukum yakni melanggar ketentuan pasal 62 PP Nomor 37 Tahun 1998, namun terhadap keterlambatan tersebut apabila Rachmawati dapat membuktikan dirinya menderita kerugian, namun jika tidak dapat membuktikan, maka PPAT tidak dapat dimintakan pertanggungan gugat berupa ganti kerugian atas dasar telah melakukan perbuatan melawan hukum sebagaimana Pasal 1365 KUH Perdata, karena unsur adanya kerugian dan hubungan kausal antara perbuatan dengan kerugian yang timbul tidak terpenuhi
Dualisme Penerapan Hukum Bagi Pelaku Kekerasan Seksual Terhadap Anak di Provinsi Aceh
Authors: Amarina habibi  
Published: September 2020

Act Number 35, 2014 on Child Protection (UUPA) and Qanun (provincial law) Aceh Number 6, 2014 regarding Qanun Jinayat has given rise to legal dualism. Both laws and regulations govern the same case in the jurisdiction of Aceh, so that it can cause problems in its enforcement. This research applies primary, secondary and tertiary legal sources. This research uses the statue approach. Library research data are then analyzed from secondary and tertiary legal sourcesby using deductive method.The research shows that the enforcement of absolute power at the judicial institutions relating the trial of the sexual offence towards children cases in Aceh, the Public Court, which is granted its power under the UUPA,is privilege compared to Syar’iyah Court, which is having its power from Qanun Jinayat. The reasons for this are as following: a) the punisment in the UUPA is more serious and cumulative, while in Qanun Jinayat is more lenient and alternative; b) UUPA regulates specific things regarding child cases, while Qanun Jinayat is general; c) the enforcement of UUPA together with its changes is still facing hurdles, and there is also the enactment of Qanun Jinayat; d) there are problems in regards with lack of facilities of the detentions and budget during the process of the cases and there is an absent of the cooperation between correctional center for the convicted under the Qanun Jinayat; e) judges in the Public Court mostly already have certificates in dealing with child case compared to Syar’iyah Court. This research found that the later court judges have not had any certificate yet. The enforcement of punishment towards the perpetrators in Aceh mostly tried under the UUPA compared to using Qanun Jinayat as it provides more justice for victims.
Introduction pages
Authors: SESTRAS Radu E. 
Published: September 2020

Notulae Botanicae Horti Agrobotanici Cluj-Napoca (NBHA), Issue 3, Volume 48, 2020: The papers published in this issue Vol 48 No 3 (2020) represent new exciting researches in different topics of life science, respectively in plant science, horticulture, agronomy and crop science. Among the interesting articles we invite you to find news about iconography of domesticated sunflower; Plants used as medicinal in Güémez, Tamaulipas, north-eastern Mexico; Variation in Nigella sativa quality and its standardization via instrumental analysis – a study based on geographical origin; Pharmacological and ADMET-based pharmacokinetic properties of Syzygium samarangense var. parviflorum leaf extract in in vitro, in vivo and in silico models; The genotypic response towards haploid induction in Turkish onion (Allium cepa L.) germplasm; The role of light in the adaptation of Thymus praecox for diverse habitat conditions etc. The new Impact Factor communicated by ISI Clarivate, June 29, 2020, is IF 2019 = 1.168 (position 149 of 234 journals, Q3 in Plant Sciences). New metrics in Scopus – Elsevier (June 22, 2020): CiteScore 1.40 (#43/84 in Horticulture); SJR 0.35 - Q2, #41/90 in Horticulture (SJR Scimago Journal).
Nadir Bir Konjenital Anomali, Frontal Ensefalosel: Vaka Sunumu
Authors: ONAT Taylan , BAŞER Emre , KARA Mustafa , YALVAÇ Ethem Serdar , DEMİR ÇALTEKİN Melike , AYDOĞAN KIRMIZI Demet 
Published: September 2020

Ensefalosel, nöral tüp defektlerinin bir
varyantıdır. Yüzey ektoderminin nöral ektodermden gebeliğin 4. haftasında
yetersiz ayrılması, ensefalosellerin oluştuğu temel mekanizmadır. İnsidansı
canlı doğumlarda 1-3/1000’dir. Ensefalosellerin sınıflandırılması lezyon
bölgesine göre yapılmaktadır ve yapılan epidemiyolojik çalışmalar ensefalosel
tiplerinin görülme oranlarının ırklar ve
coğrafi bölgeler arasında farklılık olduğunu göstermiştir. Frontal ensefalosel
batı ülkelerinde daha az sıklıkla görülen anterior ensefaloselin nadir görülen
bir örneğidir. Frontal ensefalosel yaşamla bağdaşabilen bir ensefalosel türü
olmasına rağmen ek anomali varlığında gebelik terminasyonu da aile ile beraber
değerlendirilmesi gereken bir konudur. Yirmi altı yaşında ve ilk gebeliği olan
hastanın gebeliğinin 18. haftasında frontal ensefalosel tanısı konuldu. Yapılan
ultrasonografik değerlendirmede ek anomali görülmeyen hastanın doğumu,
gebeliğinin 386/7. haftasında sezaryen ile gerçekleştirildi.
Teaching is Not Always Easy: Mexican Pre-service English Teachers’ Beliefs on Teaching and Learning
Authors: Villarreal Ballesteros Ana Cecilia , Olave Moreno Irlanda , Flores Delgado Lizette Drusila 
Published: September 2020

One of the main goals of language teacher education programs is to prepare professionals who can respond to the growing demands of society for quality instruction. However, we often find that training in current theories and methods has limited impact on pre-service teachers’ long established beliefs and ultimately on their practice. The purpose of this qualitative interpretative study is to explore the conceptual metaphors (Lakoff and Johnson, 2008) used by pre-service teachers when writing their teaching philosophy as a way of unveiling their underlying cognitive mappings. We propose that making future teachers aware of the entrenched metaphors they use to talk about teaching and learning might be a first step in changing their observable behavior. The results of this study show that in spite of exposure to current theories on teaching and learning, pre-service teachers tend to keep outdated theories. This work in conjunction with other strategies will help teacher trainers to foster integration of current ideas about teaching and learning in their students and to recognize their role in improving language education.