bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the orbital evolution of 2020 AV2, the first asteroid ever observed to go around the Sun inside the orbit of Venus
Authors: de la Fuente Marcos C , de la Fuente Marcos R 
Published: February 2020

ABSTRACT
The innermost section of the Solar system has not been extensively studied because minor bodies moving inside Earth’s orbit tend to spend most of their sidereal orbital periods at very low solar elongation, well away from the areas more frequently observed by programs searching for near-Earth objects. The survey carried out from the Zwicky Transient Facility (ZTF) is the first one that has been able to detect multiple asteroids well detached from the direct gravitational perturbation of the Earth–Moon system. ZTF discoveries include 2019 AQ3 and 2019 LF6, two Atiras with the shortest periods among known asteroids. Here, we perform an assessment of the orbital evolution of 2020 AV2, an Atira found by ZTF with a similarly short period but following a path contained entirely within the orbit of Venus. This property makes it the first known member of the elusive Vatira population. Genuine Vatiras, those long-term dynamically stable, are thought to be subjected to the so-called von Zeipel–Lidov–Kozai oscillation that protects them against close encounters with both Mercury and Venus. However, 2020 AV2 appears to be a former Atira that entered the Vatira orbital domain relatively recently. It displays an anticoupled oscillation of the values of eccentricity and inclination, but the value of the argument of perihelion may circulate. Simulations show that 2020 AV2 might reach a 3:2 resonant orbit with Venus in the future, activating the von Zeipel–Lidov–Kozai mechanism, which in turn opens the possibility to the existence of a long-term stable population of Vatiras trapped in this configuration.
xGASS: passive discs do not host unexpectedly large reservoirs of cold atomic hydrogen
Authors: Cortese L , Catinella B , Cook R H W , Janowiecki S 
Published: February 2020

ABSTRACT
We use the extended GALEX Arecibo SDSS Survey (xGASS) to quantify the relationship between atomic hydrogen (H i) reservoir and current star formation rate (SFR) for central disc galaxies. This is primarily motivated by recent claims for the existence, in this sample, of a large population of passive discs harbouring H i reservoirs as large as those observed in main-sequence galaxies. Across the stellar mass range 109 &lt; M*/M⊙ &lt; 1011, we practically find no passive (≳2σ below the star forming main sequence) disc galaxies with H i reservoirs comparable to those typical of star-forming systems. Even including H i non-detections at their upper limits, passive discs typically have ≥0.5 dex less H i than their active counterparts. We show that previous claims are due to the use of aperture-corrected SFR estimates from the MPA/JHU SDSS DR7 catalogue, which do not provide a fair representation of the global SFR of H i-rich galaxies with extended star-forming discs. Our findings confirm that the bulk of the passive disc population in the local Universe is H i-poor. These also imply that the reduction of star formation, even in central disc galaxies, has to be accompanied by a reduction in their H i reservoir.
The apparent anticorrelation between the mass opacity of interstellar dust and the surface density of interstellar gas
Authors: Priestley F D , Whitworth A P 
Published: February 2020

ABSTRACT
Recent analyses of Herschel observations suggest that in nearby disc galaxies the dust mass opacity at $500 \, {\rm \mu m}$, κ500, decreases with increasing gas surface density, ΣISM. This apparent anticorrelation between κ500 and ΣISM is opposite to the behaviour expected from theoretical dust evolution models; in such models, dust in denser, cooler regions (i.e. regions of increased ΣISM) tends to grow and therefore to have increased κ500. We show, using a toy model, that the presence of a range of dust temperatures along the line of sight can lead to spuriously low estimated values of κ500. If in regions of higher ΣISM the range of dust temperatures extends to lower values (as seems likely), the magnitude of this effect may be sufficient to explain the apparent anticorrelation between κ500 and ΣISM. Therefore there may not be any need for spatial variation in the intrinsic dust properties that run counter to theoretical expectations.
Functional analysis reveals G/U pairs critical for replication and trafficking of an infectious non-coding viroid RNA
Authors: Wu Jian , Zhou Cuiji , Li James , Li Chun , Tao Xiaorong , Leontis Neocles B , Zirbel Craig L , Bisaro David M , Ding Biao 
Published: February 2020

Abstract
While G/U pairs are present in many RNAs, the lack of molecular studies to characterize the roles of multiple G/U pairs within a single RNA limits our understanding of their biological significance. From known RNA 3D structures, we observed that the probability a G/U will form a Watson–Crick (WC) base pair depends on sequence context. We analyzed 17 G/U pairs in the 359-nucleotide genome of Potato spindle tuber viroid (PSTVd), a circular non-coding RNA that replicates and spreads systemically in host plants. Most putative G/U base pairs were experimentally supported by selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE). Deep sequencing PSTVd genomes from plants inoculated with a cloned master sequence revealed naturally occurring variants, and showed that G/U pairs are maintained to the same extent as canonical WC base pairs. Comprehensive mutational analysis demonstrated that nearly all G/U pairs are critical for replication and/or systemic spread. Two selected G/U pairs were found to be required for PSTVd entry into, but not for exit from, the host vascular system. This study identifies critical roles for G/U pairs in the survival of an infectious RNA, and increases understanding of structure-based regulation of replication and trafficking of pathogen and cellular RNAs.
The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition
Authors: Furukawa Takanori , Scheven Mareike Thea , Misslinger Matthias , Zhao Can , Hoefgen Sandra , Gsaller Fabio , Lau Jeffrey , Jöchl Christoph , Donaldson Ian , Valiante Vito , Brakhage Axel A , Bromley Michael J , Haas Hubertus , Hortschansky Peter 
Published: February 2020

Abstract
To sustain iron homeostasis, microorganisms have evolved fine-tuned mechanisms for uptake, storage and detoxification of the essential metal iron. In the human pathogen Aspergillus fumigatus, the fungal-specific bZIP-type transcription factor HapX coordinates adaption to both iron starvation and iron excess and is thereby crucial for virulence. Previous studies indicated that a HapX homodimer interacts with the CCAAT-binding complex (CBC) to cooperatively bind bipartite DNA motifs; however, the mode of HapX-DNA recognition had not been resolved. Here, combination of in vivo (genetics and ChIP-seq), in vitro (surface plasmon resonance) and phylogenetic analyses identified an astonishing plasticity of CBC:HapX:DNA interaction. DNA motifs recognized by the CBC:HapX protein complex comprise a bipartite DNA binding site 5′-CSAATN12RWT-3′ and an additional 5′-TKAN-3′ motif positioned 11–23 bp downstream of the CCAAT motif, i.e. occasionally overlapping the 3′-end of the bipartite binding site. Phylogenetic comparison taking advantage of 20 resolved Aspergillus species genomes revealed that DNA recognition by the CBC:HapX complex shows promoter-specific cross-species conservation rather than regulon-specific conservation. Moreover, we show that CBC:HapX interaction is absolutely required for all known functions of HapX. The plasticity of the CBC:HapX:DNA interaction permits fine tuning of CBC:HapX binding specificities that could support adaptation of pathogens to their host niches.
Functional effects of variation in transcription factor binding highlight long-range gene regulation by epromoters
Authors: Mitchelmore Joanna , Grinberg Nastasiya F , Wallace Chris , Spivakov Mikhail 
Published: February 2020

Abstract
Identifying DNA cis-regulatory modules (CRMs) that control the expression of specific genes is crucial for deciphering the logic of transcriptional control. Natural genetic variation can point to the possible gene regulatory function of specific sequences through their allelic associations with gene expression. However, comprehensive identification of causal regulatory sequences in brute-force association testing without incorporating prior knowledge is challenging due to limited statistical power and effects of linkage disequilibrium. Sequence variants affecting transcription factor (TF) binding at CRMs have a strong potential to influence gene regulatory function, which provides a motivation for prioritizing such variants in association testing. Here, we generate an atlas of CRMs showing predicted allelic variation in TF binding affinity in human lymphoblastoid cell lines and test their association with the expression of their putative target genes inferred from Promoter Capture Hi-C and immediate linear proximity. We reveal &gt;1300 CRM TF-binding variants associated with target gene expression, the majority of them undetected with standard association testing. A large proportion of CRMs showing associations with the expression of genes they contact in 3D localize to the promoter regions of other genes, supporting the notion of ‘epromoters’: dual-action CRMs with promoter and distal enhancer activity.
Splitting aptamers and nucleic acid enzymes for the development of advanced biosensors
Authors: Debiais Mégane , Lelievre Amandine , Smietana Michael , Müller Sabine 
Published: February 2020

AbstractIn analogy to split-protein systems, which rely on the appropriate fragmentation of protein domains, split aptamers made of two or more short nucleic acid strands have emerged as novel tools in biosensor set-ups. The concept relies on dissecting an aptamer into a series of two or more independent fragments, able to assemble in the presence of a specific target. The stability of the assembled structure can further be enhanced by functionalities that upon folding would lead to covalent end-joining of the fragments. To date, only a few aptamers have been split successfully, and application of split aptamers in biosensing approaches remains as promising as it is challenging. Further improving the stability of split aptamer target complexes and with that the sensitivity as well as efficient working modes are important tasks. Here we review functional nucleic acid assemblies that are derived from aptamers and ribozymes/DNAzymes. We focus on the thrombin, the adenosine/ATP and the cocaine split aptamers as the three most studied DNA split systems and on split DNAzyme assemblies. Furthermore, we extend the subject into split light up RNA aptamers used as mimics of the green fluorescent protein (GFP), and split ribozymes.
Long-term activity of Comet C/2007 N3 (Lulin) as monitored by the SLT at the Lulin Observatory
Authors: Lin Zhong-Yi 
Published: February 2020

Abstract
The green comet C/2007 N3 (Lulin) is a new Oort cloud comet that has a retrograde orbit (inclination of $178^{\circ }$). It reached its perihelion on 2009 January 10, and its closest distance to Earth was 0.411 astronomical units (au) on February 24. Soon after its discovery on 2007 July 11, the coma activity of Comet Lulin was monitored closely by an Super Light Telescope 41 cm telescope until 2009 April. After long-term monitoring of Comet Lulin, the dust production rate [A(θ)fρ] was estimated. An unexpected increase in the ${A(0)f\rho}$ near the perigee appears to indicate an opposition effect. By investigating the surface brightness profiles, dust-to-gas ratios, and magnitudes, we ruled out the influences of gas and ion contamination and the outburst phenomenon. We discovered the anti-tail in late December 2008 but were unsure of the composition. We found that this abnormal tail lasted for a considerable time because of the effect of the orbital geometry. We also found that the jet activity coincided with the peak ${A(\theta)f\rho}$ values, and this clue helped us realize what was happening in the dust coma of Comet Lulin.
Fair Trade and the Political Economy of Brandy Smuggling in Early Eighteenth-Century Britain*
Authors: Smith David Chan 
Published: February 2020

Abstract
Thomas Ellis, merchant of London, never expected he would be prosecuted for participating in one of the largest commercial frauds of his time. So when the Customs seized his brandy in 1731 he fought back. His case would influence parliamentary decision-making and reveal the extensive involvement of merchants in illicit trade. Ellis’s argument that he was merely a ‘fair trader’ also illuminates the moral debate over smuggling during the period as governments sought to legitimize and enforce their trading rules and tariffs. Pressured by competition from professional smugglers and the revenue demands of the state, merchants responded by developing their own rules by which they could fairly compete. Ellis’s story, and the ‘Flemish scheme’ it exposed, thereby shed light on the moral economy of early modern capitalism, the history of smuggling, and the dynamic of market ordering by increasingly assertive states.
Recommended psychological crisis intervention response to the 2019 novel coronavirus pneumonia outbreak in China: a model of West China Hospital
Authors: Zhang Jun , Wu Weili , Zhao Xin , Zhang Wei 
Published: February 2020

Abstract
The novel coronavirus pneumonia (COVID-19) epidemic has brought serious social psychological impact to the Chinese people, especially those quarantined and thus with limited access to face-to-face communication and traditional social psychological interventions. To better deal with the urgent psychological problems of people involved in the COVID-19 epidemic, we developed a new psychological crisis intervention model by utilizing internet technology. This new model, one of West China Hospital, integrates physicians, psychiatrists, psychologists and social workers into Internet platforms to carry out psychological intervention to patients, their families and medical staff. We hope this model will make a sound basis for developing a more comprehensive psychological crisis intervention response system that is applicable for urgent social and psychological problems.
Exploring the Duration of Police–Citizen Encounters
Authors: Dai Mengyan , Hu Xiaochen 
Published: February 2020

Abstract
Modern policing policy and practices emphasize the philosophy of community-oriented policing and the principles of procedural justice to improve police–community relations. Using this theoretical framework, this study examines the duration of police–citizen encounters involving domestic and non-domestic conflicts. A sample of 262 encounters from the systematic social observations in Cincinnati was analysed. The multivariate models show that officers spent less time interacting with the citizens in the lower social class and spent more time on the encounters involving assaults. Community policing specialists spent more time interacting with citizens. Considering citizens’ voice is also associated with longer duration. Policy implications of these findings are discussed.
Lepton-flavor-violating decays of the SM-like Higgs boson $h\rightarrow e_ie_j$, and $e_i \rightarrow e_j\, \gamma $ in a flipped 3-3-1 model
Authors: Hong T T , Hung H T , Phuong H H , Phuong L T T , Hue L T 
Published: February 2020

Abstract
In the framework of the flipped 3-3-1 model introduced recently [R. M. Fonseca and M. Hirsch, J. High Energy Phys. 1608, 003 (2016)], the lepton-flavor-violating (LFV) decay $\mu \rightarrow 3e$ was predicted to have a large branching ratio (Br) close to the recent experimental limit. We will show that the Br of LFV decays of the standard-model-like (SM-like) Higgs boson decays (LFVHD) Br$(h\rightarrow e_ae_b)$ may also be large. Namely, Br$(h\rightarrow \mu\tau,e\tau)$ can reach values of $\mathcal{O}(10^{-4}){-}\mathcal{O}(10^{-5})$, which will reach the upcoming experimental sensitivities. On the other hand, for LFV decays of charged leptons (cLFV) $(e_b\rightarrow e_a\gamma)$, the branching ratios are well below experimental bounds.
Differences in growth and physiological and metabolic responses among Canadian native and hybrid willows (Salix spp.) under salinity stress
Authors: Huang Xinyi , Soolanayakanahally Raju Y , Guy Robert D , Shunmugam Arun S K , Mansfield Shawn D 
Published: February 2020

AbstractGlobally, soil salinization is becoming increasingly prevalent, due to local hydrogeologic phenomena, climate change and anthropogenic activities. This has significantly curtailed current world food production and limits future production potential. In the prairie region of North America, sulfate salts, rather than sodium chloride, are often the predominant cause of soil degradation. In order to amend soil quality, revegetate salt-affected sites and recover economic loss associated with soil salinization, the establishment of short-rotation coppice plantations with willows (Salix spp.) has been suggested as a possible solution. To screen for the best candidates for such an application, 20 hybrid and 16 native willow genotypes were treated with three different salt conditions for 3 months. The treatments were designed to reflect the salt composition and concentrations on North American prairies. Under moderate salinity treatment (7 dS m−1), hybrid willows had better growth, as they established quickly while managing salt transport and mineral nutrition balance. However, native willows showed higher potential for long-term survival under severe salinity treatment (14 dS m−1), showing a lower sodium:potassium ratio in roots and better photosynthetic performance. Two native willow genotypes with high osmotic and salinity tolerance indices, specifically LAR-10 and MJW-9, are expected to show superior potential for remediating salt-affected sites. In addition, we observed significantly higher sulfate/sulfur concentrations in both leaf and root tissues in response to the severe salinity treatment, shedding light on the effect of sulfate salinity on sulfate uptake, and potentially sulfur metabolism in plants.
The PalERF109 transcription factor positively regulates salt tolerance via PalHKT1;2 in Populus alba var. pyramidalis
Authors: Chen Ningning , Tong Shaofei , Tang Hu , Zhang Zhiyang , Liu Bao , Lou Shangling , Liu Jianquan , Liu Huanhuan , Ma Tao , Jiang Yuanzhong 
Published: February 2020

Abstract
Salinity restricts the growth of trees to varying extents, but the regulatory mechanisms involved in their varying salt tolerance are largely unknown. In an effort to elucidate these mechanisms, we identified a total of 99 genes in the Ethylene Responsive Factor (ERF) family of transcription factors and examined their expression patterns under salt stress in Populus alba var. pyramidalis. We found that a B4 group gene, PalERF109, was rapidly induced by salt treatment and preferentially expressed in stems and petioles, where it is probably involved in transport of ions and water in xylem. Overexpression of PalERF109 enhanced the salt tolerance of the poplar, and further analysis showed that it directly upregulated a high-affinity K+transporter (HKT) gene, PalHKT1;2. The results clearly indicate that PalERF109 enhances salt tolerance at least partially through direct activation of PalHKT1;2 and extends understanding of the roles of ERF genes in tree stress responses.
Rethinking success, integrity, and culture in research (part 1) — A multi-actor qualitative study on success in science
Authors: Bonn Noémie Aubert , Pinxten Wim 
Published: February 2020

ABSTRACTBackgroundSuccess shapes the life and careers of scientists. But success in science is difficult to define, let alone to translate in indicators that can be used for assessment. In the past few years, several groups expressed their dissatisfaction with the indicators currently used for assessing researchers. But given the lack of agreement on what should constitute success in science, most propositions remain unanswered. This paper aims to complement our understanding of success in science and to document areas of tension and conflict in research assessments.MethodsWe conducted semi-structured interviews and focus groups with policy makers, funders, institution leaders, editors or publishers, research integrity office members, research integrity community members, laboratory technicians, researchers, research students, and former-researchers who changed career to inquire on the topics of success, integrity, and responsibilities in science. We used the Flemish biomedical landscape as a baseline to be able to grasp the views of interacting and complementary actors in a system setting.ResultsGiven the breadth of our results, we divided our findings in a two-paper series, with the current paper focusing on what defines and determines success in science. Respondents depicted success as a multi-factorial, context-dependent, and mutable factor. Success appeared to be an interaction between characteristics from the researcher (Who), research outputs (What), processes (How), and luck. Interviewees noted that current research assessments overvalued outputs but largely ignored the processes deemed essential for research quality and integrity. Interviewees sustained that we need a diversity of indicators to allow a balanced and diverse view of success; that assessments should not blindly depend on metrics but also value human input; that we must value quality over quantity; and that any indicators used must be transparent, robust, and valid.ConclusionsThe objective of research assessments may be to encourage good researchers, to benefit society, or simply to advance science. Yet we show that current assessments fall short on each of these objectives. Open and transparent inter-actor dialogue is needed to understand what research assessments aim for and how they can best achieve their objective.Trial Registrationosf.io/33v3m
Clinical Characteristics of 2019 Novel Infected Coronavirus Pneumonia: A Systemic Review and Meta-analysis
Authors: Qian Kai , Deng Yi , Tai Yong-Hang , Peng Jun , Peng Hao , Jiang Li-Hong 
Published: February 2020

ABSTRACTBackgroundA novel pneumonia associated with the 2019 coronavirus infected pneumonia (NCIP) suddenly broke out in Wuhan, China in December 2019. 37287 confirmed cases and 813 death case in China (Until 8th/Feb/2019) have been reported in just fortnight. Although this risky pneumonia with high infection rates and high mortality rates need to be resolved immediately, major gaps in our knowledge of clinical characters of it were still not be established. The aim of this study is to summaries and analysis the clinical characteristics of 2019-nCoV pneumonia.MethodsLiteratures have been systematically performed a search on PubMed, Embase, Web of Science, GreyNet International, and The Cochrane Library from inception up to February 8, 2020. The Newcastle-Ottawa Scale was used to assess quality, and publication bias was analyzed by Egger’s test. In the single-arm meta-analysis, A fix-effects model was used to obtain a pooled incidence rate. We conducted subgroup analysis according to geographic region and research scale.ResultsA total of nine studies including 356 patients were included in this study, the mean age was 52.4 years and 221 (62.1%) were male. The pooled incidences rate of symptoms as follows: pharyngalgia (12.2%, 95% CI: 0.087-0.167), diarrhea (9.2%, 95% CI: 0.062-0.133) and headache (8.9%, 95% CI: 0.063-0.125). Meanwhile, 5.7% (95% CI: 0.027-0.114) of patients were found without any symptoms although they were diagnosed by RT-PCR. In the terms of CT imaging examination, the most of patients showed bilateral mottling or ground-glass opacity, 8.6% (95% CI: 0.048-0.148) of patients with crazy-paving pattern, and 11.5% (95% CI: 0.064-0.197) of patients without obvious CT imaging presentations. The pooled incidence of mortality was 8.9% (95% CI: 0.062-0.126).ConclusionsTo our knowledge, this is the first evidence-based medicine research to further elaborate the clinical characteristics of NCIP, which is beneficial to the next step of prevention and treatment.