bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theoretical and numerical analysis and design of stiffened steel plate shear walls having unequal subpanels
Authors: Ahmadnejad Farzaneh , Gholhaki Majid , Rezayfar Omid 
Published: January 2020

SummaryFollowing the adequate seismic behavior, the steel plate shear walls have gained popularity among the designers worldwide, and many buildings have been designed employing such walls as their lateral load‐carrying system. Despite the fact that the steel shear walls using unstiffened thin plates outnumber the ones benefitting from stiffeners, it should be kept in mind that application of stiffeners prevents the buckling induced by lateral loads such earthquake or wind. On the other hand, the stiffeners enhance the stiffness and shear strength of the plate. Accordingly, this paper deals with an analytical and numerical investigation into the steel plates stiffened by unequaled vertical and horizontal stiffeners. The results obtained for the analyses led to the development of the analytical relations to compute the shear strength, stiffness, and displacement. To validate the proposed relations, analytical outputs were compared with those obtained from the numerical investigation indicating great accuracy of the proposed analytical relations. Moreover, in this paper, the design process of the stiffened steel plate shear walls has been presented based on the interaction between the plate and frame. The results indicate the addition of stiffeners to the steel plate, improves its shear strength by 6 to 15%.
New technique for automatic sonographic measurement of change in head–perineum distance and angle of progression during active phase of second stage of labor
Authors: Angeli L. , Conversano F. , Dall'Asta A. , Volpe N. , Simone M. , Di Pasquo E. , Pignatelli D. , Schera G. B. L. , Di Paola M. , Ricciardi P. , Ferretti A. , Frusca T. , Casciaro S. , Ghi T. 
Published: January 2020

ABSTRACTObjectiveTo evaluate the performance of a new ultrasound technique for the automatic assessment of the change in head–perineum distance (delta‐HPD) and angle of progression (delta‐AoP) during the active phase of the second stage of labor.MethodsThis was a prospective observational cohort study including singleton term pregnancies with fetuses in cephalic presentation during the active phase of the second stage of labor. In each patient, two videoclips of 10 s each were acquired transperineally, one in the axial and one in the sagittal plane, between rest and the acme of an expulsive effort, in order to measure HPD and AoP, respectively. The videoclips were processed offline and the difference between the acme of the pushing effort and rest in HPD (delta‐HPD) and AoP (delta‐AoP) was calculated, first manually by an experienced sonographer and then using a new automatic technique. The reliability of the automatic algorithm was evaluated by comparing the automatic measurements with those obtained manually, which was considered as the reference gold standard.ResultsOverall, 27 women were included. A significant correlation was observed between the measurements obtained by the automatic and the manual methods for both delta‐HPD (intraclass correlation coefficient (ICC) = 0.97) and delta‐AoP (ICC = 0.99). The high accuracy provided by the automatic algorithm was confirmed by the high values of the coefficient of determination (r2 = 0.98 for both delta‐HPD and delta‐AoP) and the low residual errors (root mean square error = 1.2 mm for delta‐HPD and 1.5° for delta‐AoP). A Bland–Altman analysis showed a mean difference of 0.52 mm (limits of agreement, −1.58 to 2.62 mm) for delta‐HPD (P = 0.034) and 0.35° (limits of agreement, −2.54 to 3.09°) for delta‐AoP (P = 0.39) between the manual and automatic measurements.ConclusionsThe automatic assessment of delta‐AoP and delta‐HPD during maternal pushing efforts is feasible. The automatic measurement of delta‐AoP appears to be reliable when compared with the gold standard manual measurement by an experienced operator. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd.
On design, modelling, and analysis of a 10‐MW medium‐speed drivetrain for offshore wind turbines
Authors: Wang Shuaishuai , Nejad Amir R. , Moan Torgeir 
Published: January 2020

AbstractThe design of a medium‐speed drivetrain for the Technical University of Denmark (DTU) 10‐MW reference offshore wind turbine is presented. A four‐point support drivetrain layout that is equipped with a gearbox with two planetary stages and one parallel stage is proposed. Then, the drivetrain components are designed based on design loads and criteria that are recommended in relevant international standards. Finally, an optimized drivetrain model is obtained via an iterative design process that minimizes the weight and volume. A high‐fidelity numerical model is established via the multibody system approach. Then, the developed drivetrain model is compared with the simplified model that was proposed by DTU, and the two models agree well. In addition, a drivetrain resonance evaluation is conducted based on the Campbell diagrams and the modal energy distribution. Detailed parameters for the drivetrain design and dynamic modelling are provided to support the reproduction of the drivetrain model. A decoupled approach, which consists of global aero‐hydro‐servo‐elastic analysis and local drivetrain analysis, is used to determine the drivetrain dynamic response. The 20‐year fatigue damages of gears and bearings are calculated based on the stress or load duration distributions, the Palmgren‐Miner linear accumulative damage hypothesis, and long‐term environmental condition distributions. Then, an inspection priority map is established based on the failure ranking of the drivetrain components, which supports drivetrain inspection and maintenance assessment and further model optimization. The detailed modelling of the baseline drivetrain model provides a basis for benchmark studies and support for future research on multimegawatt offshore wind turbines.
Metabolic regulation of neurodifferentiation in the adult brain
Authors: Maffezzini Camilla , Calvo-Garrido Javier , Wredenberg Anna , Freyer Christoph 
Published: January 2020

AbstractUnderstanding the mechanisms behind neurodifferentiation in adults will be an important milestone in our quest to identify treatment strategies for cognitive disorders observed during our natural ageing or disease. It is now clear that the maturation of neural stem cells to neurones, fully integrated into neuronal circuits requires a complete remodelling of cellular metabolism, including switching the cellular energy source. Mitochondria are central for this transition and are increasingly seen as the regulatory hub in defining neural stem cell fate and neurodevelopment. This review explores our current knowledge of metabolism during adult neurodifferentiation.
q-Independence of the Jimbo–Drinfeld Quantization
Authors: Giselsson Olof 
Published: January 2020

AbstractLet$${\mathrm {G}}$$Gbe a connected semi-simple compact Lie group and for$$0<q<1$$0<q<1, let$$({\mathbb {C}}[\mathrm {G]_q},\varDelta _q)$$(C[G]q,Δq)be the Jimbo–Drinfeldq-deformation of$${\mathrm {G}}$$G. We show that the$$C^*$$C∗-completions of$$\mathrm {C}[\mathrm {G]_q}$$C[G]qare isomorphic for all values ofq. Moreover, these isomorphisms are equivariant with respect to the right-actions of the maximal torus.
Risk Factors for Occult Lymph Node Metastasis in Peripheral Non‐Small Cell Lung Cancer with Invasive Component Size 3 cm or Less
Authors: Moon Youngkyu , Choi Si Young , Park Jae Kil , Lee Kyo Young 
Published: January 2020

AbstractBackgroundIn the seventh edition TNM staging system for lung cancer, a high maximum standardized uptake value (SUVmax) on positron emission tomography was regarded as a risk factor for occult lymph node metastasis in clinical T1N0 non‐small cell lung cancer (NSCLC). However, in the eighth edition TNM classification, tumors are classified according to the size of the invasive component only, and those with invasive component size ≤3 cm are diagnosed as stage T1. The aim of this study was to reassess the risk factors for occult lymph node metastasis under the eighth edition TNM classification for lung cancer.MethodsFrom 2010 to 2017, 553 patients with clinical N0 peripheral NSCLC with invasive component size ≤3 cm underwent anatomical lobectomy with systematic lymph node dissection. We analyzed these cases retrospectively to identify risk factors for postoperative nodal upstaging.ResultsAmong 553 study patients, 54 (9.8%) had nodal upstaging after surgery. In multivariate analysis adopting the eighth edition TNM classification for lung cancer, serum carcinoembryonic antigen (CEA) level (hazard ratio [HR] = 1.113, p = 0.002), invasive component size (HR = 2.398, p = 0.004), visceral pleural invasion (HR = 2.901, p = 0.005), and lymphatic invasion (HR = 9.336, p < 0.001) were significant risk factors for nodal upstaging, but SUVmax was not.ConclusionSUVmax is not a predictor of nodal upstaging in clinical N0 peripheral NSCLC with invasive component size ≤3 cm under the eighth edition TNM classification for lung cancer. Significant risk factors of occult lymph node metastasis are serum CEA level, tumor invasive component size, visceral pleural invasion, and lymphatic invasion.
Clinical burden of severe respiratory syncytial virus infection during the first 2 years of life in children born between 2000 and 2011 in Scotland
Authors: Thwaites Richard , Buchan Scot , Fullarton John , Morris Carole , Grubb ElizaBeth , Rodgers-Gray Barry , Coutts Jonathan 
Published: January 2020

AbstractNational data from Scotland (all births from 2000 to 2011) were used to estimate the burden associated with respiratory syncytial virus hospitalisation (RSVH) during the first 2 years of life. RSVHs were identified using the International Classification of Diseases 10th Revision codes. Of 623,770 children, 13,362 (2.1%) had ≥ 1 RSVH by 2 years, with the overall rate being 27.2/1000 (16,946 total RSVHs). Median age at first RSVH was 137 days (interquartile range [IQR] 62–264), with 84.3% of admissions occurring by 1 year. Median length of stay was 2 (IQR 1–4) days and intensive care unit (ICU) admission was required by 4.3% (727) for a median 5 (IQR 2–8) days. RSVHs accounted for 6.9% (5089/73,525) of ICU bed days and 6.2% (64,395/1,033,121) of overall bed days (5370/year). RSVHs represented 8.5% (14,243/168,205) of all admissions between October and March and 14.2% (8470/59,535) between December and January. RSVH incidence ranged from 1.7 to 2.5%/year over the study period. Preterms (RSVH incidence 5.2%), and those with congenital heart disease (10.5%), congenital lung disease (11.2%), Down syndrome (14.8%), cerebral palsy (15.5%), cystic fibrosis (12.6%), and neuromuscular disorders (17.0%) were at increased risk of RSVH.Conclusions: RSV causes a substantial burden on Scottish paediatric services during the winter months.What is known:• Respiratory syncytial virus (RSV) is a leading cause of childhood hospitalisation.What is new:• This 12-year study is the first to estimate the burden of RSV hospitalisation (RSVH) in Scotland and included all live births from 2000 to 2011 and followed > 600,000 children until 2 years old.• The overall RSVH rate was 27.2/1000 children, with 2.1% being hospitalised ≥ 1 times.• RSVHs accounted for 6.2% of all inpatient bed days, which rose to 14.2% during the peak months of the RSV season (December–January), equating to over 1400 hospitalisations and nearly 5500 bed days each year.
Portal hypertensive gastropathy is associated with iron deficiency anemia
Authors: Simbrunner Benedikt , Beer Andrea , Wöran Katharina , Schmitz Fabian , Primas Christian , Wewalka Marlene , Pinter Matthias , Dolak Werner , Scheiner Bernhard , Puespoek Andreas , Trauner Michael , Oberhuber Georg , Mandorfer Mattias , Reiberger Thomas 
Published: January 2020

Summary
Background and aims
Portal hypertensive gastropathy (PHG) is common in patients with cirrhosis and may cause bleeding. This study systematically explored the independent impact of patient characteristics, portal hypertension and hepatic dysfunction on PHG severity and associated anemia.

Methods
Patients with cirrhosis undergoing endoscopy were included in this retrospective analysis and PHG was endoscopically graded as absent, mild or severe. Clinical and laboratory parameters and hepatic venous pressure gradient (HVPG) were assessed with respect to an association with severity of PHG.

Results
A total of 110 patients (mean age: 57 years, 69% male) with mostly alcoholic liver disease (49%) or viral hepatitis (30%) were included: 15 (13.6%) patients had no PHG, 59 (53.6%) had mild PHG, and 36 (32.7%) had severe PHG. Severe PHG was significantly associated with male sex (83.3% vs. 62.2% in no or mild PHG; p = 0.024) and higher Child-Turcotte-Pugh (CTP) stage (CTP-C: 38.9% vs. 27.0% in no or mild PHG; p = 0.030), while MELD was similar (p = 0.253). Patients with severe PHG had significantly lower hemoglobin values (11.2 ± 0.4 g/dL vs. 12.4 ± 0.2 g/dL; p = 0.008) and a higher prevalence of iron-deficiency anemia (IDA: 48.5% vs. 26.9%; p = 0.032). Interestingly, HVPG was not significantly higher in severe PHG (median 20 mm Hg) vs. mild PHG (19 mm Hg) and no PHG (18 mm Hg; p = 0.252). On multivariate analysis, CTP score (odds ratio, OR: 1.25, 95% confidence interval, CI 1.02–1.53; p = 0.033) was independently associated with severe PHG, while only a trend towards an independent association with IDA was observed (OR: 2.28, 95% CI 0.91–5.72; p = 0.078).

Conclusion
The CTP score but not HVPG or MELD were risk factors for severe PHG. Importantly, anemia and especially IDA are significantly more common in patients with severe PHG.
Mechanistic evaluation of long-term in-stent restenosis based on models of tissue damage and growth
Authors: He Ran , Zhao Liguo , Silberschmidt Vadim V. , Liu Yang 
Published: January 2020

AbstractDevelopment and application of advanced mechanical models of soft tissues and their growth represent one of the main directions in modern mechanics of solids. Such models are increasingly used to deal with complex biomedical problems. Prediction of in-stent restenosis for patients treated with coronary stents remains a highly challenging task. Using a finite element method, this paper presents a mechanistic approach to evaluate the development of in-stent restenosis in an artery following stent implantation. Hyperelastic models with damage, verified with experimental results, are used to describe the level of tissue damage in arterial layers and plaque caused by such intervention. A tissue-growth model, associated with vessel damage, is adopted to describe the growth behaviour of a media layer after stent implantation. Narrowing of lumen diameter with time is used to quantify the development of in-stent restenosis in the vessel after stenting. It is demonstrated that stent designs and materials strongly affect the stenting-induced damage in the media layer and the subsequent development of in-stent restenosis. The larger the artery expansion achieved during balloon inflation, the higher the damage introduced to the media layer, leading to an increased level of in-stent restenosis. In addition, the development of in-stent restenosis is directly correlated with the artery expansion during the stent deployment. The correlation is further used to predict the effect of a complex clinical procedure, such as stent overlapping, on the level of in-stent restenosis developed after percutaneous coronary intervention.
Truthmaker Semantics for Relevant Logic
Authors: Jago Mark 
Published: January 2020

AbstractI develop and defend a truthmaker semantics for the relevant logic R. The approach begins with a simple philosophical idea and develops it in various directions, so as to build a technically adequate relevant semantics. The central philosophical idea is that truths are true in virtue of specific states. Developing the idea formally results in a semantics on which truthmakers are relevant to what they make true. A very natural notion of conditionality is added, giving us relevant implication. I then investigate ways to add conjunction, disjunction, and negation; and I discuss how to justify contraposition and excluded middle within a truthmaker semantics.
Linking collision, slab break-off and subduction polarity reversal in the evolution of the Central Indian Tectonic Zone
Authors: Deshmukh Tanzil , Prabhakar N. 
Published: January 2020

AbstractThe Central Indian Tectonic Zone demarcates the zone of amalgamation between the North Indian Craton and the South Indian Craton. Presently, the major controversies in the existing tectonic models of the Central Indian Tectonic Zone revolve around the direction of subduction and the precise timing of accretion between the North Indian Craton and the South Indian Craton. A new model for the tectonic evolution of the Central Indian Tectonic Zone is postulated in this contribution, based on recent geological and geophysical evidence, combined with previously documented tectonic configurations. The present study employs the slab break-off hypothesis and subsequent polarity reversal to explain the tectonic processes involved in the evolution of the Central Indian Tectonic Zone. We propose that the subduction initiated (c. 2.5 Ga) in a S-directed system producing island-arc sequences on the South Indian Craton. The southward subduction regime culminated with slab break-off underneath the South Indian Craton betweenc. 1.65 Ga and 1.55 Ga, which subsequently induced subduction polarity reversal and set the course for N-directed subduction (<1.55 Ga). The final closure along the Central Indian Tectonic Zone is governed by the collisional regime during the Sausar Orogeny (1.0–0.9 Ga).
Unequal benefits – diverging attitudes? Analysing the effects of an unequal expansion of childcare provision on attitudes towards maternal employment across 18 European countries
Authors: Neimanns Erik 
Published: January 2020

AbstractChildcare policies have become an important element of social investment reforms, but in most countries access to childcare has remained socially unequal. Some studies have suggested that a trend towards more gender egalitarian work–family attitudes has facilitated the expansion of childcare provision. Yet, we know little about the repercussions of an unequal expansion of childcare provision on public attitudes towards the work–family nexus. Building on multilevel models of 18 European countries and two waves of the International Social Survey Programme, this analysis examines the effects of an unequal childcare expansion on attitudes towards maternal employment. The results reveal that individuals with lower income remain more skeptical of maternal employment when childcare provision is highly unequal. The unequally distributed benefits of an expansion of childcare provision contribute to a divergence of attitudes across socio-economic groups, which might create a more difficult political terrain for the implementation of expansive social investment reforms.
Rain fade slope model for terrestrial microwave links
Authors: Chebil Jalel , Islam Md. Rafiqul , Zyoud Al-Hareth , Habaebi Mohamed Hadi , Dao Hassan 
Published: January 2020

AbstractThe dynamic characteristic of rain fade slope is one important factor in determining the availability of a communication system, and it is very useful in the design of fade countermeasures. In the literature, many models were proposed for rain fade slope for earth-to-satellite links. However, there are no models available for rain fade point to point terrestrial microwave links. This paper proposes a new model for the estimation of rain fade slope statistics for terrestrial microwave links in tropical regions. First, the ITU-R model for rain fade slope for earth-to-satellite link was compared with the corresponding statistics obtained from rain attenuation data measured from three terrestrial links in Malaysia. It is found that the expression of its distribution and its standard deviation should be modified. This leads to the derivation of the proposed rain fade slope model based on the statistics of one link. Then, it is tested using the remaining data and its results were very close to the measured statistics for all attenuation levels higher than 1 dB. Moreover, the model was validated using the chi-square goodness-of-fit test.
The Impact of Nonbreaking Waves on Wind‐Driven Ocean Surface Turbulence
Authors: Savelyev I. B. , Buckley M. P. , Haus B. K. 
Published: January 2020

AbstractA comprehensive study on the properties of upper ocean turbulence and its response to a variety of wind and wave forcing conditions was conducted at the Surge Structure Atmosphere INteraction (SUSTAIN) facility, University of Miami, RSMAS. The dimensions of SUSTAIN wind‐wave‐current tunnel are 18 m long, 6 m wide, and 2 m high, uniquely allowing for freely forming turbulence unconstrained by side walls. The grid of input parameters covered a range of wave steepness (ak: 0–0.27) within each investigated wind speed (U10: 2–20 m/s), allowing for the isolation of wave effects on the turbulence driven by both wind and waves. The response of turbulence to each pair of wind‐wave parameters was measured in steady‐state conditions (after 20+ min of settling time) by a suite of nonintrusive turbulence visualization techniques, located at 10 m fetch. These included 3‐D visualization of water tracing dye entrainment by turbulence, underwater particle image velocimetry, and passive and active thermal imagery resolving surface skin temperature and velocity fluctuations. The resulting data set includes both qualitative 3‐D view of subsurface turbulent structures and precise quantitative turbulent kinetic energy (TKE) measurements mapped out in response to the grid of input parameters. In lower winds, TKE was found to grow substantially in response to increasing wave steepness, in line with the expected effect of increasing wave forcing. However, in higher winds the effect of increasing wave steepness on TKE was found to be negative. It is hypothesized to be due to the rise of airflow separation, effectively sheltering much of the water surface from turbulence production by wind friction.
Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration
Authors: Pool Fran M. , Kiel Christina , Serrano Luis , Luthert Philip J. 
Published: January 2020

AbstractAge-related macular degeneration (AMD) is one of the commonest causes of sight loss in the elderly population and to date there is no intervention that slows or prevents early AMD disease progressing to blinding neovascularization or geographic atrophy. AMD is a complex disease and factors proposed to contribute to the development and progression of disease include aging, genetics, epigenetics, oxidative stress, pro-inflammatory state, and life-style factors such as smoking, alcohol, and high fat diet. Here, we generate a knowledge repository of pathways and protein–protein interaction (PPI) networks likely to be implicated in AMD pathogenesis, such as complement activation, lipid trafficking and metabolism, vitamin A cycle, oxidative stress, proteostasis, bioenergetics, autophagy/mitophagy, extracellular matrix (ECM) turnover, and choroidal vascular dropout. Two disctinct clusters ermerged from the networks for parainflamation and ECM homeostasis, which may represent two different disease modules underlying AMD pathology. Our analyses also suggest that the disease manifests primarily in RPE/choroid and less in neural retina. The use of standardized syntax when generating maps of these biological processes (SBGN standard) and networks (PSI standard) enables visualization of complex information in graphical programs such as CellDesigner and Cytoscape and enhances reusability and extension of data. The ability to focus onto subnetworks, multiple visualizations and simulation options will enable the AMD research community to computationally model subnetworks or to test experimentally new hypotheses arising from connectivities in the AMD pathway map.