bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of physical development and state of health in ART-conceived children with retinopathy of prematurity: a population, one-time study
Authors: Plaksina Anna N. , Kovtun Olga P. , Stepanova Elena A. , Dugina Elena A. , Makutina Valeriya A. , Sinotova Svetlana L. , Limanovskaya Oksana V. 
Published: July 2020

Background. Assisted reproductive technology (ART) poses an increased risk for preterm birth. Women with high body mass index, who opted for ART, have the elevated levels of the insulin-like growth factor 1 (IGF-1) which is involved in the development of pathologic vasoproliferation in retinopathy of prematurity (ROP). Children with ROP are at increased risk for co-morbid pathology.Objective. The study aims at evaluating physical development and state of health in ART-conceived children with ROP.Methods. This is a population, one-time study to evaluate physical development and state of health in children with ROP. Statistical analysis was carried out using the SPSS v. 14.0 software package, and included determination of normality (Shapiro-Wilk test), descriptive statistics (М — mean value, σ — standard deviation of the mean), and non-parametric methods (Mann-Whitney U-test, Z-test of a proportion).Results. The anthropometric characteristics of infants with ROP did not differ from those in spontaneously conceived babies. Children with ROP born to mothers with high BMI had lower anthropometric parameters (p < 0.001) and required longer dynamic follow-up while being diagnosed as “risk group for ROP”. A significantly higher number (a total of 65) of nosologies has been revealed in the ART-conceived infants. Statistically significant predominant diagnoses (p = 0.0047) included dwarfism and obesity despite the absence of anthropometric differences at birth (p = 0.123).Conclusion. The ART-conceived infants with ROP at birth do not differ in their physical development from infants in the general population, however, on prospective follow-up the former developed dwarfism and obesity significantly more often. Children born to mothers with high BMI have significantly lower parameters of weight and height, and require longer follow-up period while being diagnosed with ROP. The ART-conceived infants with ROP have co-morbid pathology significantly more often than children with ROP in the control group.
Pneumonia with negative chest radiography in early childhood: is it a real phenomenon or diagnostic error?
Authors: Tsarkova Sofya A. , Abdullaev Alexander N. , Surovceva Darya A. , Pomazkina Anna V. 
Published: July 2020

Background. The existence of community-acquired pneumonia with negative chest radiography (CAPNR) as a clinical phenomenon remains disputable until now. This phenomenon is deemed to occur in subjects with dehydration, neutropenia, diminished immune response. In case of CAPNR the possibility of diagnostic error and ensuing irrational use of antimicrobial drugs is fairly high.Objective. The study aimed at establishing the validity of diagnosis of pneumonia with negative chest radiography in children, using a comparative evaluation of clinical and laboratory criteria amid positive and negative results of radiological diagnosis of pneumonia.Methods. A one-time study was conducted which included analysis of medical documents selected by continuous sampling method, and comparison of children with CAPNR versus children with radiologically confirmed pneumonia. The comparison was based on analysis of medical histories, clinical pictures and results of paraclinical investigations.Results. A total of 35 medical histories have been analyzed (mean age of patients – 1.7 ± 0.2 years), of which 17 children were assigned to group 1 (CAPNR group) and 18 children to group 2 (pneumonia with positive radiography). Most clinical and laboratory signs in early childhood were similar for children with CAPNR and children with radiologically confirmed pneumonia. Veritable differences in terms of respiratory symptoms have been found for children with CAPNR, namely, expiratory dyspnea in 35.29% of children with CAPNR versus none in the comparator group (p < 0.05), respiratory rate (RR) — 33 ± 7.2/min versus 28 ± 7.3/ min in the comparator group (p < 0.05), and auscultatory findings showing predominantly diminished breath sounds on the right-hand side. Complete blood count showed differences in granulocyte counts — 70 ± 12.6% in the CAPNR group versus 62.9 ± 16.8% in the comparator group (p < 0.05). A combination of the majority of classical symptoms of community-acquired pneumonia has been rarely observed in either group (5.9% and 11.1%, respectively).Conclusion. Particular features of the CAPNR did not allow us to speak out with confidence in favor or against the diagnosis of community-acquired pneumonia (CAP) in patient groups. The conduct of prospective studies looking into the etiology of pneumonia, using radiologic and ultrasound diagnosis and analyzing clinical and laboratory particulars of CAP would be a worthwhile undertaking. Without radiographic identification of infiltrative changes the diagnosis of CAP remains problematic.
Case report: a child with cystic fibrosis and phenylketonuria
Authors: Vakhlova Irina V. , Kazachina Anastasia D. , Beglyanina Olga A. 
Published: July 2020

Background. In the international clinical practice there have been occasional reports of phenylketonuria (PKU) and cystic fibrosis (CF) found simultaneously in the same patient. Both PKU and CF are the inherited disorders characterized by autosomal recessive type of inheritance. Currently the combination of two or more inherited disorders in one patient is considered to be a clinical rarity.Case description. This is a clinical case of two genetic disorders, CF and PKU, combined in a 5-year old patient who had been followed up since birth. Owing to implementation of neonatal screening for inherited and congenital diseases into clinical practice, during the first month of life the infant was diagnosed with CF (diagnostically significant elevation of immunoreactive trypsin [IRT] at the initial [163.2 ng/mL] and repeat testing on day 21 of life [138.7 ng/mL]) and PKU (phenylalanine [PA] level 15.9 mg/dL). Both disorders have been confirmed by genetic tests, i.e., homozygous DelF508 mutation was found in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and P281L mutation in the phenylalanine hydroxylase (PAH) gene was also present in homozygous state. Child’s parents strictly adhered to dietary and treatment recommendations. By the age of 5 years the child developed symptoms of neurological disorder and disorder of the respiratory system, cognitive impairment and delay in speech development, subclinical epileptiform activity with high risk of epilepsy, and chronic inflammation of the respiratory tract.Conclusion. This case report demonstrates the important role of neonatal screening in early diagnosis and timely start of therapy, and underscores the importance of continuous medication in such genetic disorders as CF and PKU. On the whole, such approach brings about a relative preservation of functioning of the most affected organs and systems. By the age of 5 years the child does not form bronchiectases, shows no signs of chronic hypoxia, nutritional deficiency or pronounced neurologic deficit, and is at low risk for the development of autism spectrum disorder. At the same time, the larger scale and longer-term observations are required in order to make the unequivocal conclusions about the prognosis of these diseases under conditions of modern-day medical follow-up.
Glulam columns made of European beech timber: compressive strength and stiffness parallel to the grain, buckling resistance and adaptation of the effective-length method according to Eurocode 5
Authors: Ehrhart Thomas , Steiger René , Palma Pedro , Gehri Ernst , Frangi Andrea 
Published: July 2020

AbstractThis article presents experimental and numerical investigations on the buckling behaviour of glulam columns made of European beech (Fagus sylvatica L.) timber and a design proposal. First, the compressive strength parallel to the grain ($$\textit{f}_{\mathrm{c,0}}$$

f

c
,
0

) and the modulus of elasticity parallel to the grain ($$\textit{E}_{\mathrm{c,0}}$$

E

c
,
0

) were experimentally determined in tests on stocky columns (slenderness ratio $$\lambda = 12.5$$

λ
=
12.5

) of strength classes GL 40h, GL 48h, and GL 55h. Subsequent experimental buckling tests on slender columns with buckling lengths of 2.40 m ($$\lambda = 41.5$$

λ
=
41.5

) and 3.60 m ($$\lambda = 62.3$$

λ
=
62.3

) allowed investigating the buckling behaviour and quantifying the influence of the buckling length on the buckling resistance. Applicability of the effective-length method, which is the design method for columns in Eurocode 5 (EN 1995-1-1: Design of timber structures - Part 1-1: General - Common rules and rules for buildings. European Committee for Standardization, Brussels, 2010), was evaluated and a proposal for input parameters valid for columns made of European beech glulam is made. Numerical simulations revealed buckling resistances very close to the experimental results, confirming the proposed critical relative slenderness ratio $$\lambda _{\mathrm{rel,0}} = 0.25$$

λ

rel
,
0

=
0.25

and the fitted straightness factor $$\beta _{\mathrm{c}} = 0.25$$

β
c

=
0.25

. In addition, the numerical simulations allowed for an extension of the scope of the investigations.
Novel Models Predict Postsurgical Recurrence and Overall Survival for Patients with Hepatitis B Virus-Related Solitary Hepatocellular Carcinoma ≤10 cm and Without Portal Venous Tumor Thrombus
Authors: Wang Xiao-Hui , Liao Bing , Hu Wen-Jie , Tu Cai-Xue , Xiang Cai-Ling , Hao Sheng-Hua , Mao Xian-Hai , Qiu Xiao-Ming , Yang Xiao-Jun , Yue Xiao , Kuang Ming , Peng Bao-Gang , Li Shao-Qiang 
Published: July 2020

Abstract

Background
The predictive model of postsurgical recurrence for solitary early hepatocellular carcinoma (SE-HCC) is not well established. The aim of this study was to develop a novel model for prediction of postsurgical recurrence and survival for patients with hepatitis B virus (HBV)-related SE-HCC ≤10 cm.

Patients and Methods
Data from 1,081 patients with HBV-related SE-HCC ≤10 cm who underwent curative liver resection from 2003 to 2016 in our center were collected retrospectively and randomly divided into the derivation cohort (n = 811) and the internal validation cohort (n = 270). Eight hundred twenty-three patients selected from another four tertiary hospitals served as the external validation cohort. Postsurgical recurrence-free survival (RFS) and overall survival (OS) predictive nomograms were generated. The discriminatory accuracies of the nomograms were compared with six conventional hepatocellular carcinoma (HCC) staging systems.

Results
Tumor size, differentiation, microscopic vascular invasion, preoperative α-fetoprotein, neutrophil-to-lymphocyte ratio, albumin-to-bilirubin ratio, and blood transfusion were identified as the risk factors associated with RFS and OS. RFS and OS predictive nomograms based on these seven variables were generated. The C-index was 0.83 (95% confidence interval [CI], 0.79–0.87) for the RFS-nomogram and 0.87 (95% CI, 0.83–0.91) for the OS-nomogram. Calibration curves showed good agreement between actual observation and nomogram prediction. Both C-indices of the two nomograms were substantially higher than those of the six conventional HCC staging systems (0.54–0.74 for RFS; 0.58–0.76 for OS) and those of HCC nomograms reported in literature.

Conclusion
The novel nomograms were shown to be accurate at predicting postoperative recurrence and OS for patients with HBV-related SE-HCC ≤10 cm after curative liver resection.
The Canadian Health Clock and health calculators
Authors: Choi Bernard C. K. , Manuel Douglas G. 
Published: July 2020

Abstract
Setting
This paper documents a participatory process of Health Portfolio staff in the design of a clock, and announces the 2020 Canadian Health Clock, with links to numerous online health calculators. The clock is part of the Health Portfolio’s celebration activities in 2019 of “100 Years of Health”, as the Department of Health was established in Canada in 1919.

Intervention
The intervention was the development of a clock on the Government of Canada website with linkage to calculators as a health promotion tool. The clock was built on the concept of the 2004 Chronic Disease Clock, which shows the number of deaths so far today, and so far this year. The clock was developed using a consultative approach, following a review of the original clock.

Outcomes
The 2020 clock incorporates new data visualization concepts. New features, facilitated by improved technology, include: expansion to all causes of death; blinking red dots to enhance visual impact; and three clock versions (analogue, featuring a moving circle; digital, table format; and graphical, bar chart format). The clock also provides links to a number of health calculators, to allow people to seek personalized information to improve their health.

Implications
The online health clock and health calculators are good examples of innovation in health risk communication tools for effective knowledge translation and dissemination. They inform people about health statistics (clock) and their health (calculators). The clock engages people in the context of the Canadian population, whereas the calculators provide personalized information about improving an individual’s future health.
Six Major Historical Earthquakes in the Seoul Metropolitan Area during the Joseon Dynasty (1392–1910)
Authors: Park Seongjun , Baek Inho , Hong Tae-Kyung 
Published: July 2020

ABSTRACTEarthquake records in the historical literature provide valuable information on the seismic hazard potentials for long recurrence times. The Seoul metropolitan area is the center of the economy and infrastructure in South Korea. Six major earthquakes that occurred around the Seoul metropolitan area during the Joseon dynasty in 1392–1910 are analyzed using a probabilistic joint inversion method based on seismic damage records and earthquake-felt reports. The inversion yields sets of event locations and magnitudes with probabilities. The joint inversion method is validated with synthetic and instrumentally observed data sets. The historical earthquakes are found to be located around the Seoul metropolitan area. The magnitudes of the earthquakes range from ML 5.3 to 6.8 at the peak probabilistic locations. These historical earthquakes suggest considerable seismic hazard potentials in the Seoul metropolitan area.
Automatic Extraction of Permanent Ground Offset from Near-Field Accelerograms: Algorithm, Validation, and Application to the 2004 Parkfield Earthquake
Authors: Inbal Asaf , Ziv Alon 
Published: July 2020

ABSTRACTPermanent ground offsets, constituting a prime dataset for constraining final fault-slip distributions, may not be recovered straightforwardly by double integration of near-field accelerograms due to tilt and other distorting effects. Clearly, if a way could be found to recover permanent ground offsets from acceleration records, then static datasets would be enlarged, and thus the resolution of fault-slip inversions would be enhanced. Here, we introduce a new approach for extracting permanent offsets from near-field strong-motion accelerograms. The main advantage of the new approach with respect to previous ones is that it corrects for source time functions of any level of complexity. Its main novelty is the addition of a constraint on the slope of the ground velocity spectra at long periods. We validated the new scheme using collocated accelerograms and Global Navigation Satellite Systems (GNSS) records of the 2011 Mw 9 Tohoku-Oki earthquake. We find a good agreement between accelerogram-based and GNSS-based ground offsets over a range of 0.1–5 m. To improve the spatial coverage of permanent ground offsets associated with the 2004 Parkfield earthquake, near-field accelerograms were baseline corrected using the new scheme. Static slip inversion of the combined GNSS-based and accelerogram-based ground displacements indicates appreciable seismic moment release south of the epicenter, about 5 km into the Cholame section of the San Andreas fault. We conclude that the strong shaking observed to the south of the epicenter is directly related to the slip in that area and is not the result of local amplification.
Conditional Ground-Motion Model for Damaging Characteristics of Near-Fault Ground Motions Based on Instantaneous Power
Authors: Zengin Esra , Abrahamson Norman 
Published: July 2020

ABSTRACTThe velocity pulse in near-fault ground motions has been used as a key characteristic of damaging ground motions. Characterization of the velocity pulse involves three parameters: presence of the pulse, period of the pulse, and amplitude of the pulse. The basic concept behind the velocity pulse is that a large amount of seismic energy is packed into a short time, leading to larger demands on the structure. An intensity measure for near-fault ground motions, which is a direct measure of the amount of energy arriving in short time, called instantaneous power (IP (T1)), is defined as the maximum power of the bandpass-filtered velocity time series measured over a time interval of 0.5T1, in which T1 is the fundamental period of the structure. The records are bandpass filtered in the period band (0.2T1−3T1) to remove the frequencies that are not expected to excite the structure. Zengin and Abrahamson (2020) showed that the drift is better correlated with the IP (T1) than with the velocity pulse parameters for records scaled to the same spectral acceleration at T1. A conditional ground-motion model (GMM) for the IP is developed based on the 5%-damped spectral acceleration at T1, the earthquake magnitude, and the rupture distance. This conditional GMM can be used for record selection for near-fault ground motions that captures the key features of velocity pulses and can lead to a better representation of the median and variability of the maximum interstory drift. The conditional GMM can also be used in a vector hazard analysis for spectral acceleration (T1) and IP (T1) that can be used for more accurate estimation of drift hazard and seismic risk.
Evaluación del desempeño de un amortiguador de masa sintonizado no lineal mediante simulaciones híbridas en tiempo real
Authors: Riascos-González Carlos Andrés , Thomson Peter , Dyke Shirley 
Published: July 2020

Introducción: En este artículo se describe la simulación híbrida en tiempo real (RTHS) de un amortiguador no lineal de masa sintonizado (NTMD) y se comparan los resultados con los obtenidos de ensayos experimentales convencionales de una estructura a cortante, de un piso, con el NTMD.
Objetivo: El objetivo de este artículo es valuar la efectividad de una RTHS para estimar el desempeño de un NTMD.
Metodología: La metodología consistió de las siguientes tres etapas: identificación de la estructura principal, diseño del NTMD y evaluación experimental del sistema estructura-NTMD. Para la tercera etapa, se utilizaron RTHS y ensayos sobre mesa vibratoria.
Resultados: Los resultados de los ensayos en mesa vibratoria demostraron que el NTMD redujo el 77% y 63% de las aceleraciones pico y RMS de la estructura principal, con respecto a la estructura sin control. Los valores de estas reducciones obtenidos con RTHS fueron 73% y 63%, respectivamente. Los índices de precisión del sistema de transferencia correspondieron a una amplitud generalizada de 1.01 y un retraso de 2 ms.
Conclusiones: el NTMD, con una razón de masas del 10%, alcanzó reducciones superiores al 60% de la respuesta estructural. La RTHS y el ensayo de mesa vibratoria demostraron que el sistema estructura-NTMD tuvo solo un pico en la respuesta en frecuencia. El ruido en la retroalimentación de la RTHS aumentó el grado de amortiguamiento de la estructura controlada. Finalmente, los resultados experimentales demostraron que la RTHS es una técnica que predice efectivamente la aceleración RMS del sistema estructura-NTMD y puede sobreestimar ligeramente su aceleración pico.
Exoesqueleto para rehabilitación de miembro inferior con dos grados de libertad orientado a pacientes con accidentes cerebrovasculares
Authors: Tibaduiza-Burgos Diego Alexander , Aya Parra Pedro Antonio , Anaya Vejar Maribel 
Published: July 2020

Introducción: Un exoesqueleto puede ser entendido como una estructura mecatrónica que puede ser acoplada a una extremidad de manera externa y que permite el desarrollo de los movimientos en las diferentes articulaciones de esta misma. Estos movimientos son desarrollados con el apoyo de actuadores que son quienes definen los grados de libertad de este tipo de dispositivos. Dada su versatilidad, estos pueden llegar a ser una herramienta útil en la asistencia de trabajos de rehabilitación de miembros superior e inferior humanos y en algunos casos por ejemplo ayudar a pacientes con parálisis en sus miembros en el desarrollo de actividades tan complejas como la marcha humana. Aunque hay algunos desarrollos importantes en esta área, esta sigue en fase de investigación y muchos de los desarrollos aún no están disponibles o no son asequibles para su uso masivo en países como Colombia y en general América Latina.
Objetivo: Este trabajo presenta el desarrollo de un exoesqueleto activo, el cual fue diseñado para ayudar en la rehabilitación de pacientes que han tenido algún tipo de secuela como consecuencia de un accidente cerebro vascular (ACV), también conocido como Ictus.
Metodología: Se incluye dentro del artículo, información sobre el modelado del sistema, el diseño, control y la construcción del dispositivo exoesquelético así como el desarrollo de unas pruebas preliminares orientadas a mostrar su uso en el desarrollo de pruebas de repetición en el plano sagital
Resultados: Como resultado se cuenta con un prototipo funcional que ya fue validado con pruebas de laboratorio y que permite monitorizar los movimientos de las articulaciones en un proceso de terapia en miembro inferior basada en ejercicios de repetición.
Conclusiones: El sistema desarrollado presenta algunas facilidades que pueden ser útiles en la rehabilitación de pacientes con ictus, entre ellas se tienen las siguientes: desarrollo de un sistema automatizado de monitorización de rehabilitación, diseño mecánico y estructura ajustable a diferentes tipos de pacientes, modelado del sistema y desarrollo de sistema de control automático, así como facilidad de uso de interfaz desarrollada en Labview.
Estudio sedimentológico en la cuenca de la quebrada La Floresta en los municipios de Pailitas y Tamalameque, departamento del Cesar, Colombia
Authors: Manco Jaraba Dino Carmelo , Rudas Muñoz Antonio , Rojas Martínez Elías Ernesto 
Published: July 2020

Introducción: La quebrada La Floresta se localiza entre los municipios de Pailitas y Tamalameque, cuenta con una extensión de 13.500 hectáreas, donde se realizaron estudios granulométricos, humedad y estimación de volumen de sedimentos aportados por la cuenca mediante el modelo EROSUP-U.
Objetivo: Cuantificar el aporte sedimentológico de la quebrada La Floresta y clasificar tipos de suelo basado en AASTHO y USC.
Metodología: Se recolectaron 84 muestras, cada 10 mts y 15 mts, siguiendo la metodología propuesta por la Comisión Federal de Electricidad de México.
Resultados: La estimación volumétrica, aplicando la ecuación universal de perdida de suelo (EUPS), establece que el aporte sedimentológico de la quebrada es de 4.944.679.344,77 m3/año; el suelo se clasificó en cuatro (4) grupos (A-1-a, A-1-b, A-2-4, A-2-6), el más representativo es el A-1-a con un 84.52% de las muestras analizadas.
Conclusiones: La quebrada La Floresta cuenta con una amplia variabilidad granulométrica de sedimentos, siendo de mayor proporción las grava, arena gruesa y arena fina, con o sin material fino bien graduado, con predominio de gravas y un aporte sedimentológico de 4.944.679.344,77 m3/año.