bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shaping caustics into propagation-invariant light
Authors: Zannotti Alessandro , Denz Cornelia , Alonso Miguel A. , Dennis Mark R. 
Published: July 2020

AbstractStructured light has revolutionized optical particle manipulation, nano-scaled material processing, and high-resolution imaging. In particular, propagation-invariant light fields such as Bessel, Airy, or Mathieu beams show high robustness and have a self-healing nature. To generalize such beneficial features, these light fields can be understood in terms of caustics. However, only simple caustics have found applications in material processing, optical trapping, or cell microscopy. Thus, these technologies would greatly benefit from methods to engineer arbitrary intensity shapes well beyond the standard families of caustics. We introduce a general approach to arbitrarily shape propagation-invariant beams by smart beam design based on caustics. We develop two complementary methods, and demonstrate various propagation-invariant beams experimentally, ranging from simple geometric shapes to complex image configurations such as words. Our approach generalizes caustic light from the currently known small subset to a complete set of tailored propagation-invariant caustics with intensities concentrated around any desired curve.
Molecular hydrogen in minerals as a clue to interpret ∂D variations in the mantle
Authors: Moine B. N. , Bolfan-Casanova N. , Radu I. B. , Ionov D. A. , Costin G. , Korsakov A. V. , Golovin A. V. , Oleinikov O. B. , Deloule E. , Cottin J. Y. 
Published: July 2020

AbstractTrace amounts of water dissolved in minerals affect density, viscosity and melting behaviour of the Earth’s mantle and play an important role in global tectonics, magmatism and volatile cycle. Water concentrations and the ratios of hydrogen isotopes in the mantle give insight into these processes, as well as into the origin of terrestrial water. Here we show the presence of molecular H2 in minerals (omphacites) from eclogites from the Kaapvaal and Siberian cratons. These omphacites contain both high amounts of H2 (70 to 460 wt. ppm) and OH. Furthermore, their ∂D values increase with dehydration, suggesting a positive H isotope fractionation factor between minerals and H2–bearing fluid, contrary to what is expected in case of isotopic exchange between minerals and H2O-fluids. The possibility of incorporation of large quantities of H as H2 in nominally anhydrous minerals implies that the storage capacity of H in the mantle may have been underestimated, and sheds new light on H isotope variations in mantle magmas and minerals.
3D genome organization contributes to genome instability at fragile sites
Authors: Sarni Dan , Sasaki Takayo , Irony Tur-Sinai Michal , Miron Karin , Rivera-Mulia Juan Carlos , Magnuson Brian , Ljungman Mats , Gilbert David M. , Kerem Batsheva 
Published: July 2020

AbstractCommon fragile sites (CFSs) are regions susceptible to replication stress and are hotspots for chromosomal instability in cancer. Several features were suggested to underlie CFS instability, however, these features are prevalent across the genome. Therefore, the molecular mechanisms underlying CFS instability remain unclear. Here, we explore the transcriptional profile and DNA replication timing (RT) under mild replication stress in the context of the 3D genome organization. The results reveal a fragility signature, comprised of a TAD boundary overlapping a highly transcribed large gene with APH-induced RT-delay. This signature enables precise mapping of core fragility regions in known CFSs and identification of novel fragile sites. CFS stability may be compromised by incomplete DNA replication and repair in TAD boundaries core fragility regions leading to genomic instability. The identified fragility signature will allow for a more comprehensive mapping of CFSs and pave the way for investigating mechanisms promoting genomic instability in cancer.
Carbon nanotube porin diffusion in mixed composition supported lipid bilayers
Authors: Sullivan Kylee , Zhang Yuliang , Lopez Joseph , Lowe Mary , Noy Aleksandr 
Published: July 2020

AbstractCarbon nanotube porins (CNTPs), short pieces of carbon nanotubes capable of self-inserting into a lipid bilayer, represent a simplified model of biological membrane channels. We have used high-speed atomic force microscopy (HS-AFM) and all-atom molecular dynamics (MD) simulations to study the behavior of CNTPs in a mixed lipid membrane consisting of DOPC lipid with a variable percentage of DMPC lipid added to it. HS-AFM data reveal that the CNTPs undergo diffusive motion in the bilayer plane. Motion trajectories extracted from the HS-AFM movies indicate that CNTPs exhibit diffusion coefficient values broadly similar to values reported for membrane proteins in supported lipid bilayers. The data also indicate that increasing the percentage of DMPC leads to a marked slowing of CNTP diffusion. MD simulations reveal a CNTP-lipid assembly that diffuses in the membrane and show trends that are consistent with the experimental observations.
Routing space exploration for scalable routing in the quantum Internet
Authors: Gyongyosi Laszlo , Imre Sandor 
Published: July 2020

AbstractThe entangled network structure of the quantum Internet formulates a high complexity routing space that is hard to explore. Scalable routing is a routing method that can determine an optimal routing at particular subnetwork conditions in the quantum Internet to perform a high-performance and low-complexity routing in the entangled structure. Here, we define a method for routing space exploration and scalable routing in the quantum Internet. We prove that scalable routing allows a compact and efficient routing in the entangled networks of the quantum Internet.
Fluctuation relations and fitness landscapes of growing cell populations
Authors: Genthon Arthur , Lacoste David 
Published: July 2020

AbstractWe construct a pathwise formulation of a growing population of cells, based on two different samplings of lineages within the population, namely the forward and backward samplings. We show that a general symmetry relation, called fluctuation relation relates these two samplings, independently of the model used to generate divisions and growth in the cell population. These relations lead to estimators of the population growth rate, which can be very efficient as we demonstrate by an analysis of a set of mother machine data. These fluctuation relations lead to general and important inequalities between the mean number of divisions and the doubling time of the population. We also study the fitness landscape, a concept based on the two samplings mentioned above, which quantifies the correlations between a phenotypic trait of interest and the number of divisions. We obtain explicit results when the trait is the age or the size, for age and size-controlled models.
Polymorphic phase transition in liquid and supercritical carbon dioxide
Authors: Pipich Vitaliy , Schwahn Dietmar 
Published: July 2020

AbstractWe present experiments on molecular density fluctuations in liquid and supercritical (SC) CO2 using small-angle neutron scattering. Thermal density fluctuations in SC-CO2 determine susceptibility and correlation length identifying the Widom line at their maxima. Droplet formation occurs at the gas–liquid line and between 20 and 60 bar above the Widom line, the corresponding borderline identified as the Frenkel line. The droplets start to form spheres of constant radius of ≈ 45 Å and transform into rods and globules at higher pressure. Droplet formation represents a liquid–liquid (polymorphic) phase transition of the same composition but different density, whose difference defines its order parameter. Polymorphism in CO2 is a new observation stimulating interesting discussions on the topics of gas-like to liquid-like transition in SC fluids and polymorphism since CO2 represents a “simple” van der Waals liquid in contrast to water, which is the most widely studied liquid showing polymorphism in its supercooled state.
Evaluating the accuracy of hand models obtained from two 3D scanning techniques
Authors: Yu Fang , Zeng Lei , Pan Ding , Sui Xinlei , Tang Juyu 
Published: July 2020

AbstractThe aim of this study was to identify an efficient approach for 3D imaging of hand. The 3D photographs of hand were taken with Gemini structured-light scanning system (SL scanning) and CT scanning. The 3D photographs, average time of scanning and reconstruction were compared between these two indirect techniques. The reliability, reproducibility and accuracy were evaluated in these two indirect techniques and the direct measurement (DM). Statistical differences in the measurements were assessed by 99% probability, with clinical significance at > 0.5 mm. The Gemini structured-light scanning system established a complete and smooth 3D hand photograph with shorter scanning and reconstruction time. Reproducibility of CT scanning and SL scanning methods was better (P < 0.01, both) than the DM, but did not differ significantly from each other (P = 0.462). Of the 19 (31.58%) measurements obtained, 6 showed significant differences (P < 0.01). Significant differences were observed more often for circumference dimensions (5/9, 55.56%) than for length dimensions (1/10, 10%). Mean absolute error (AE) of the 10 subjects was very low for 3D CT (0.29 ± 0.10 mm) and SL scanning (0.30 ± 0.11 mm). Absolute percentage error (APE) was 4.69 ± 2.33% and 4.88 ± 2.22% for 3D CT and SL scanning, respectively. AE for the PIP circumference between the 3rd finger (0.58 mm) and 4th finger (0.53 mm) scan was > 0.5 mm, indicating significant difference between DM and CT scanning at the level of 99% probability. In this study, the Gemini structured-light scanning system not only successfully established a complete and smooth 3D hand photograph, but also shortened the scanning and reconstruction time. Compared to the DM, measurements obtained using the two indirect techniques did not show any statistically or clinically insignificant difference in the values of the remaining 17 of 19 measurements (89.47%). Therefore, either of the two alternative techniques could be used instead of the direct measurement method.
Low energy irradiation of narrow-range UV-LED prevents osteosarcopenia associated with vitamin D deficiency in senescence-accelerated mouse prone 6
Authors: Makida Kazuya , Nishida Yoshihiro , Morita Daigo , Ochiai Satoshi , Higuchi Yoshitoshi , Seki Taisuke , Ikuta Kunihiro , Ishiguro Naoki 
Published: July 2020

AbstractDeficiency of vitamin D is an important cause of osteosarcopenia. The purpose of this study is to examine the effects of low energy narrow-range UV-LED on osteosarcopenia in animal models of senescence-accelerated mouse prone 6 (SAMP6). Preliminary experiments specified the minimum irradiance intensity and dose efficacy for vitamin D production (316 nm, 0.16 mW/cm2, 1,000 J/m2). we set a total of 4 groups (n = 8 per group); vitamin D-repletion without UV irradiation (Vit.D+UV−), vitamin D-repletion with UV irradiation (Vit.D+UV +), vitamin D-deficiency without UV irradiation, (Vit.D−UV−), and vitamin D-deficiency with UV irradiation (Vit.D−UV +). Serum levels of 25(OH)D at 28 and 36 weeks of age were increased in Vit.D−UV+ group as compared with Vit.D−UV− group. Trabecular bone mineral density on micro-CT was higher in Vit.D−UV+ group than in Vit.D−UV− group at 36 weeks of age. In the histological assay, fewer osteoclasts were observed in Vit.D−UV+ group than in Vit.D−UV− group. Grip strength and muscle mass were higher in Vit.D−UV+ group than in Vit.D−UV− group at 36 weeks of age. Signs of severe damage induced by UV irradiation was not found in skin histology. Low energy narrow-range UV irradiation may improve osteosarcopenia associated with vitamin D deficiency in SAMP6.
Structure equation model and neural network analyses to predict coronary artery lesions in Kawasaki disease: a single-centre retrospective study
Authors: Azuma Junji , Yamamoto Takehisa , Nitta Motoaki , Hasegawa Yasuhiro , Kijima Eri , Shimotsuji Tsunesuke , Mizoguchi Yoshimi 
Published: July 2020

AbstractA new method to predict coronary artery lesions (CALs) in Kawasaki disease (KD) was developed using a mean structure equation model (SEM) and neural networks (Nnet). There were 314 admitted children with KD who met at least four of the six diagnostic criteria for KD. We defined CALs as the presence of a maximum z score of ≥ 3.0. The SEM using age, sex, intravenous immunoglobulin resistance, number of steroid pulse therapy sessions, C-reactive protein level, and urinary β2-microglobulin (u-β2MG/Cr) values revealed a perfect fit based on the root mean square error of approximation with an R2 value of 1.000 and the excellent discrimination of CALs with a sample score (SS) of 2.0 for a latent variable. The Nnet analysis enabled us to predict CALs with a sensitivity, specificity and c-index of 73%, 99% and 0.86, respectively. This good and simple statistical model that uses common parameters in clinical medicine is useful in deciding the appropriate therapy to prevent CALs in Japanese KD patients.
Cryogenic sequenced layering for the 3D reconstruction of biological objects
Authors: Nikolenko Vladimir Nikolaevich , Terpilovsky Alexey Anatolyevich , Kuzmin Alexey Leonidovich , Lukashkina Regina Alekseevna , Strizhkov Alexey Evgenievich , Suslov Andrei Vladimirovich , Kochurova Ekaterina Vladimirovna , Gavrushova Liliya Vladimirovna , Sinelnikov Mikhail Yegorovich 
Published: July 2020

AbstractThree-dimensional (3D) visualization is applied throughout many specialities, prompting an important breakthrough in accessibility and modeling of data. Experimental rendering and computerized reconstruction of objects has influenced many scientific achievements, facilitating one of the greatest advancements in medical education since the first illustrated anatomy book changed specialist training forever. Modern medicine relies on detailed, high quality virtual models for educational, experimental and clinical purposes. Almost all current virtual visualization methods rely on object slicing producing serial sections, which can then be digitalized or analyzed manually. The tendency to computerize serial sections roots from convenience, accessibility, decent visualization quality and automation capabilities. Drawbacks of serial section imaging is tissue damage occurring within each consequent sectioning. To utilize the important aspects of real-life object reconstruction, and maintain integrity of biological structures, we suggest a novel method of low-temperature layering of objects for digitization and computerized virtual reconstruction. Here we show the process of consequent imaging of each novel layer of a biological object, which provides a computer with high quality data for virtual reconstruction and creation of a multidimensional real-life model. Our method prevents tissue deformation and biodegradation due to specific methods used in preparation of the biological object. The resulting images can be applied in surgical training, medical education and numerous scientific fields for realistic reconstruction of biological objects.
Eye alignment changes caused by sustained GDNF treatment of an extraocular muscle in infant non-human primates
Authors: Fleuriet Jérome , Willoughby Christy L. , Kueppers Rachel B. , Mustari Michael J. , McLoon Linda K. 
Published: July 2020

AbstractThe ability of sustained treatment of a single extraocular muscle with glial cell line-derived neurotrophic factor (GDNF) to produce a strabismus in infant non-human primates was tested. Six infant non-human primates received a pellet containing GDNF, releasing 2 µg/day for 90 days, on one medial rectus muscle. Eye alignment was assessed up to 6 months. Five of the six animals showed a slow decrease in eye misalignment from the significant exotropia present at birth, ending with approximately 10° of exotropia. Controls became orthotropic. Misalignment averaged 8° three months after treatment ended. After sustained GDNF treatment, few changes were seen in mean myofiber cross-sectional areas compared to age-matched naïve controls. Neuromuscular junction number was unaltered in the medial rectus muscles, but were significantly reduced in the untreated lateral recti. Neuromuscular junctions on slow fibers became multiply innervated after this sustained GDNF treatment. Pitx2-positive cells significantly decreased in treated and contralateral medial rectus muscles. Our study suggests that balanced GDNF signaling plays a role in normal development and maintenance of orthotropia. Sustained GDNF treatment of one medial rectus muscle resulted in a measurable misalignment largely maintained 3 months after treatment ended. Structural changes suggest mechanisms for producing an imbalance in muscle function.
Nano-scale depth-varying recrystallization of oblique Ar+ sputtered Si(111) layers
Authors: Gupta Divya , Umapathy G. R. , Singhal Rahul , Ojha Sunil , Aggarwal Sanjeev 
Published: July 2020

AbstractSilicon, the workhorse of semiconductor industry, is being exploited for various functional applications in numerous fields of nanotechnology. In this paper, we report the fabrication of depth controllable amorphous silicon (a-Si) layers under 80 keV Ar+ ion sputtering at off-normal ion incidences of 30°, 40° and 50° and crystallization of these amorphous Si(111) layers under thermal annealing. We find that the irradiated samples were not fully amorphized even for the lowest oblique incidence of 30°. Sputtering at off-normal incidences induces depth controllable surface amorphization in Si(111). Annealing at temperature of 1,073 K is characterized by formation of depth-varying buried amorphous layer due to defect recrystallization and damage recovery. Some remnant tensile stress has been observed for recrystallized samples even for lowest oblique incidence. The correlation of amorphization and stress due to sputtering induced by oblique incidence has been discussed systematically. The possible mechanism of recrystallization is discussed in terms of vacancies produced in sputtering dominated regime and their migration during annealing treatment. Our results reveal that with appropriate selection of oblique ion beam sputtering parameters, depth controllable surface amorphization and recrystallization may be fine-tuned to achieve co-existing amorphous and crystalline phases, playing a crucial role in fabrication of substrates for IC industry.
Effect of generation rate on transient photoconductivity of semi-insulating 4H-SiC
Authors: Suproniuk Marek , Wierzbowski Mariusz , Paziewski Piotr 
Published: July 2020

AbstractThe effect of generation rate on transient photoconductivity of semi-insulating (SI) 4H-SiC is discussed. The rate of generation of electron–hole pairs is dependent on the number of photons incident on the sample material and its absorption and reflection coefficients. The number of photons and their energy is dependent on the radiation power and wavelength of the light source illuminating the material. The results of research, obtained with a specialized simulator, present the influence of changes in the filling of individual defect centres’ levels on changes in conductivity of the test material observed after switching on the photoexcitation. For the purpose of simulations, presented is a versatile model of semiconductor material. It encompasses six point defects that appear in SI 4H-SiC materials the most often. Those defect centres correspond to Z1/2 recombination centre, deep electron and deep hole traps, nitrogen-related shallow donors of two kinds and a boron-related shallow acceptor. The simulation results can be used to design and determine properties of photoconductive switches.
Speech-Language Pathology Management for Adults With COVID-19 in the Acute Hospital Setting: Initial Recommendations to Guide Clinical Practice
Authors: Namasivayam-MacDonald Ashwini M. , Riquelme Luis F. 
Published: July 2020

Purpose
This document outlines initial recommendations for speech-language pathology management of adult patients with COVID-19 in the acute hospital setting.

Method
The authors initially developed these recommendations by adapting those developed for physical therapists working with patients with COVID-19 by Thomas et al. (2020). The recommendations then underwent review by 14 speech-language pathologists and rehabilitation-focused academics representing seven countries (Belgium, Brazil, Canada, Ireland, Japan, New Zealand, the United States). The authors consolidated and reviewed the feedback in order to decide what should be included or modified. Applicability to a global audience was intended throughout the document.

Results
The authors had 100% agreement on the elements of the recommendations that needed to be changed/modified or added. The final document includes recommendations for speech-language pathology workforce planning and preparation, caseload management, service delivery and documentation, as well as recommendations for the selection of appropriate personal protective equipment and augmentative and alternative communication equipment in the acute care hospital setting.

Conclusions
Speech-language pathologists play a critical role in the assessment, management, and treatment of patients with COVID-19. Several important considerations need to be made in order to meet the needs of this unique patient population. As more is learned about the impact of the virus on swallowing and communication, the role of the speech-language pathologist on interdisciplinary care teams will remain paramount.
Tonal Language Speakers Are Better Able to Segregate Competing Speech According to Talker Sex Differences
Authors: Zhang Juan , Wang Xing , Wang Ning-yu , Fu Xin , Gan Tian , Galvin John J. , Willis Shelby , Xu Kevin , Thomas Mathew , Fu Qian-Jie 
Published: July 2020

Purpose
The aim of this study was to compare release from masking (RM) between Mandarin-speaking and English-speaking listeners with normal hearing for competing speech when target–masker sex cues, spatial cues, or both were available.

Method
Speech recognition thresholds (SRTs) for competing speech were measured in 21 Mandarin-speaking and 15 English-speaking adults with normal hearing using a modified coordinate response measure task. SRTs were measured for target sentences produced by a male talker in the presence of two masker talkers (different male talkers or female talkers). The target sentence was always presented directly in front of the listener, and the maskers were either colocated with the target or were spatially separated from the target (+90°, −90°). Stimuli were presented via headphones and were virtually spatialized using head-related transfer functions. Three masker conditions were used to measure RM relative to the baseline condition: (a) talker sex cues, (b) spatial cues, or (c) combined talker sex and spatial cues.

Results
The results showed large amounts of RM according to talker sex and/or spatial cues. There was no significant difference in SRTs between Chinese and English listeners for the baseline condition, where no talker sex or spatial cues were available. Furthermore, there was no significant difference in RM between Chinese and English listeners when spatial cues were available. However, RM was significantly larger for Chinese listeners when talker sex cues or combined talker sex and spatial cues were available.

Conclusion
Listeners who speak a tonal language such as Mandarin Chinese may be able to take greater advantage of talker sex cues than listeners who do not speak a tonal language.