bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact Of Implementation Of A Breech Clinic In A Tertiary Hospital
Authors: Derisbourg Sara , Costa Elena , De Luca Laura , Amirgholami Soraya , Kamdem Valery Bogne , Vercoutere An , Alexander Sophie , Zhang Wei Hong , Buekens Pierre , Englert Yvon , Pintiaux Axelle , Daelemans Caroline 
Published: March 2020

Abstract
BACKGROUND Breech presentations concern three to five percent of singleton pregnancies at term. In order to support eligible women in their choice of mode of delivery, a dedicated breech clinic with a care pathway was developed in December 2015 at the ‘Hôpital Universitaire Erasme’. The primary objective of this study is to compare the vaginal delivery rates before and after the implementation of the breech clinic. The secondary objective is to compare the early neonatal outcomes before and after the breech clinic was introduced. METHOD This is a monocentric retrospective and prospective study. The inclusion criteria were term (from 37 weeks) singleton fetus and breech presentation at delivery. The exclusion criteria were suspected intrauterine growth restriction, severe fetal malformations and intrauterine fetal demise. We used a composite outcome as an indicator of neonatal morbi-mortality. RESULTS After the introduction of the breech clinic, we observed a significant increase in planned vaginal delivery from 7.4% (12/162) to 53.04% (61/115) (OR: 13.5; 95%CI: 6.7-27.04). The effective vaginal breech delivery rate (planned and unplanned) significantly increased from 4.3% (7/162) pre-implementation of breech clinic to 43.5% (50/115) post-implementation (OR: 17.0; 95%CI: 7.3-39.6). CONCLUSION The implementation of a breech clinic has led to an increase in vaginal deliveries for breech babies.
Cancer Development and Mortality Differences in Patients with Glomerulonephritis after Renal Biopsy: A Single Center Retrospective Cohort Study
Authors: Ryu Hyunjin , Kim Kipyo , Ryu Jiwon , Son Hyung-Eun , Ryu Ji-Young , Kim Sejoong , Na Ki Young , Chae Dong Wan , Chin Ho Jun 
Published: March 2020

Abstract
Background: The association between glomerulonephritis (GN) and cancer has been well known for decades. However, studies evaluating long-term de novo cancer development in patients with GN are limited. This study aimed to evaluate the incidence of cancer development among patients with renal biopsy-proven GN during post-biopsy follow-up and the differences in outcomes according to cancer occurrence. Methods: We conducted a retrospective cohort study of adult patients who underwent renal biopsy at Seoul National Bundang Hospital between 2003 and 2017. After excluding 671 patients who are inappropriate for the analysis, 929 patients were included in the analysis. Data on baseline clinical characteristics, renal biopsy results, and types and doses of immunosuppressant agents used during follow-up were collected from electronic medical records. The incidence of cancer was censored on the date when the first cancer was diagnosed. We evaluated rates of mortality and end-stage renal disease (ESRD) development during follow-up. Results: During a mean follow-up period of 52.4 (range: 1.0–166.7) months, 49 subjects (5.3%) developed de novo cancer. A comparison of clinical characteristics between subjects who did and did not develop cancer revealed that cancer patients were older and had higher comorbidities and immunosuppressant use. Overall, patients with GN had an elevated standardized incidence ratio (SIR) of 7.17 (95% confidence interval (CI): 5.3–9.51) relative to the general population. In particular, the SIR was significantly higher in GNs such as membranous nephropathy (MN), IgA nephropathy, lupus nephritis, and focal segmental glomerulosclerosis. Multivariable Cox proportional hazard model adjusted for confounding variables revealed that patients with a pathologic diagnosis of MN had an increased risk of cancer development, with a hazard ratio of 2.6 [95% CI: 1.32–5.30]. Patients with MN who developed cancer had a significantly higher risk of mortality (hazard ratio: 5.95; 95% CI: 1.36–26.09, P=0.018) than those without cancer, but there was a non-significant difference in ESRD development. Conclusions: Patients with GN without concurrent cancer, particularly those with MN, have significantly higher risks of cancer development and subsequent mortality and should remain aware of the potential development of malignancy during follow-up.
Effect of silver diammine fluoride on micro-ecology of plaque from extensive caries of primary teeth - in vitro study
Authors: Liu Baoying , LIU Jin , ZHANG Di , YANG Zhi lei , FENG Ya ping , WANG Meng 
Published: March 2020

Abstract
Background

The mechanism of action of silver diammine fluoride (SDF) on plaque micro-ecology is seldom studied. This study investigated micro-ecological changes in dental plaque on extensive caries of deciduous teeth after topical SDF treatment.

Methods

Deciduous teeth with extensive caries freshly removed from school children were collected in clinic. Unstimulated saliva collection and initial plaque sampling were done before tooth extraction, then each caries was topically treated with 38% SDF in vitro. After intervention, each tooth was stored respectively in artificial saliva at 37°C. Repeated plaque collections were done at 24 hours and 1 week post-intervention. Post-intervention micro-ecological changes including microbial diversity, microbial metabolism function as well as species correlations were analyzed and compared after pyrosequencing of the DNA from the plaque sample using Illumina MiSeq platform.

Results

After SDF application, microbial diversity decreased (p>0.05), although not statistically significant. Microbial community composition post-intervention was noticeably different from that of supragingival and pre-intervention plaque as well as saliva. At 1 week post-intervention, the relative content of Pseudomonas , Fusobacterium and Pseudoramibacter was noticeably higher than before, while most of the other bacteria was noticeably reduced, although not statistically significant (P>0.05). The inter-microbial associations became more complex, much more positive associations among survived bacteria were observed than negative ones. COG function classification diagram showed carbohydrate transportation and metabolic functions in the plaque were significantly reduced at 24 hours and 1 week post-intervention.

Conclusions

SDF has extensive antimicrobial effect on dental plaque, which may reduce carbohydrate metabolism in dental plaque and help promote new balance of the plaque flora.
Learning curve of digital intraoral scanning – an in vivo study
Authors: Róth Ivett , Czigola Alexandra , Joós-Kovács Gellért Levente , Dalos Magdolna , Hermann Péter , Borbély Judit 
Published: March 2020

Abstract
Background The spread of digital technology in dentistry poses new challenges and goals for dentists. It is important to involve new methods and devices in university education. The aim of the present in vivo study was to determine the learning curve of IOS described by (1) scanning time and (2) image number (count of images made by intraoral scanner during scanning process).Methods Ten dental students of Semmelweis University took part in the study. Dental students took digital study impressions using 3Shape Trios 3® (Copenhagen, Denmark) IOS device. Each student took 10 digital impressions on volunteers (for standardization the first and the last patients was the same for each student). The inclusion criteria of patients were full dentition (except missing third molar) and no prosthetic- restorative treatment. Digital impression taking was preceded by a lecture consisting of two parts: education and training. For standardization, the scanning device was calibrated before impression taking, followed by the registration of patient data. Digital impressions were taken of the upper and lower arches, and the bite was recorded according to the manufacturer's instructions. Total scanning time and image number of intraoral scanning were recorded.Results The difference of scanning time between the first and the tenth digital impressions was significant (p=0.007). The average scanning time of first impressions was 23min 9sec, for tenth impressions it was 15min 28sec. The difference between scanning time of the first and the tenth impressions was 7min 41sec. The average image number of the first impressions was 1964.5, for the tenth impressions it was 1468.6. The difference between number of images of the first and the tenth impressions was 495,9. The curve of image number show decreasing tendency first, then has a trough around the sixth measurement, and rises.Conclusion The learning curve of IOS can be described with scanning time and image number of digital impression. Scanning time decreases as result of practice. Shorter scanning times are accompanied by poorer coverage quality, the operator has to correct by adding extra images represented by the curve of image numbers which turning into increasing tendency after the sixth measurement.Trial registration: The permission for this study was given by the University Ethics Committee of Semmelweis University (SE TUKEB number: 61/2016).
Molecular characterization of the viral structural protein genes of 2018 dengue virus serotype 1 epidemic in Yunnan, Southwest China
Authors: Lan Qingping , Shu Yun , Li Linhao , Shan Xiyun , Ma Dehong , Li Tingting , Wang Xiaodan , Pan Yue , Chen Junying , Zhang Juan , Liu Pinghua , Sun Qiangming 
Published: March 2020

Abstract
Background There was a dengue virus serotype 1 (DENV-1) epidemic from October to December in 2018 in Xishuangbanna, Yunnan, southwest China, neighboring Myanmar, Laos and Vietnam. And the molecular characterization, evolution and potential source of DENV from Xishuangbanna were investigate. Methods C (capsid)/prM(premembrane)/E (envelope) genes of DNEV isolated from 87 serum samples obtained from local patients were amplified and sequenced, then evaluated using mutation, phylogenetic and homologous recombination analyses and secondary structure prediction. Results Phylogenetic analysis show that all the DENV strains from Xishuangbanna can grouped in two branch of DENV-1. Out of 52, 50 of isolates were grouped in branch one, and were most similar to Fujian (DQ193572) and Singapore 2016(MF314188) strains. The other two isolates have the closest relationship to Myanmar 2017 (MG679801) . When compared with DENV-1SS (standard strain), we found the amino acid residue of E155 was mutation from T to S,which may related to the virulence of virus and no obvious homologous recombination signals. Secondary structure prediction showed that some changes were found in the helical of MN123849 and MN123854 strains and few changes observed in disordered region. Conclusions This study revealed the molecular characterization of structural genes of xishuangbanna, 2018 epidemic strain, providing a reference for molecular epidemiology, infection, pathogenicity and vaccine development .
CONSIDERAÇÕES SOBRE AS SUBJETIVIDADES, OS INTERSTÍCIOS E O CAPITALISMO.
Authors: Leite Leonardo Perdigão 
Published: March 2020

O presente trabalho consiste em uma revisão bibliográfica acerca do tema da subjetividade, entendida como uma negociação entre os elementos humanos, não humanos e os ambientes. Desta forma, o objetivo é mostrar como a produção da subjetividade passa pelo o que Debaise (2013) chama de dinâmica da infecção, ou seja, que há uma negociação entre as diversas partes envolvidas e que é necessário que haja interesse nas interações entre esses elementos. Por esse viés, o indivíduo e sua interioridade não são os principais responsáveis na produção de subjetividade. Os atores não humanos e o espaço passam a ter papel fundamental na produção das subjetividades e são parte constituinte dos sujeitos, levando-os a desenvolver certas atividades, gostos e emoções. Faz-se necessário reforçar que a dinâmica é dada a partir dos encontros e das trocas ocorridas entre os diversos elementos que entram em relação. Ademais, são tecidas considerações sobre a importância da produção de subjetividade para a manutenção do sistema capitalista de produção.
Performance of retention soil filters for the reduction of hygienically-relevant microorganisms in combined sewage overflow and treated wastewater
Authors: Zacharias N. , Essert S. M. , Brunsch A. F. , Christoffels E. , Kistemann T. , Schreiber C. 
Published: March 2020

Abstract
Environmental quality standards for surface waters have been significantly expanded through recent amendments to German regulations. Limit values are only established for applicable regulations if the water is indicated for certain uses, e.g. abstraction of irrigation water. Nevertheless, surface water bodies are often used for hygiene-sensitive purposes. In the course of climate change, stronger precipitation events will occur, which may lead to more frequent loading and discharge of combined sewer overflow (CSO) into surface water bodies. Retention soil filters (RSFs) are attracting attention as an extensive treatment technology for CSO and additional wastewater treatment. This study examined large-scale RSFs for CSO treatment, as well as the effectiveness of RSFs as a fourth purification stage. An RSF test facility was established at a municipal wastewater treatment plant (WWTP), consisting three semi-technical RSFs that were fed exclusively with treated water from the WWTP. The reduction of microorganisms mostly occurred within the first centimeters of the RSFs. For most hygienic-microbiological parameters, a 1–2 log unit reduction could be detected in addition to the reduction within the WWTP. Antibiotic-resistant bacteria were reduced to the same extent. Investigation of the large-scale RSFs showed that a flow rate reduced by half corresponded to better reduction performances.
Visitor Analysis on Effectiveness of Photographs towards Quality of Life: A case study of the Royal Museum Kuala Lumpur
Authors: Zubir Zahari , Isip Prince Favis , Ahamad Nurul Alia , Hussain Nor Hayati 
Published: March 2020

This research investigates the effectiveness of photographs in enhancing, creating attachment and appreciation towards memories of historical events which took place in the former National Palace of Kuala Lumpur. The purpose of this research is to study the effectiveness of the use of photographs for the appreciation of the museum from the visitors' perspective. The research findings provide recommendations to museum curators and administrators for better decision making on the utilization and display of photographs in the Royal Museum and other museums in general.Keywords: Royal Museum Kuala Lumpur; photographs; appreciation; effectiveness.eISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
Selecting Evidence-Based Content for Inclusion in Self-Management Apps for Pressure Injuries in Individuals With Spinal Cord Injury: Participatory Design Study
Authors: Fiordelli Maddalena , Zanini Claudia , Amann Julia , Scheel-Sailer Anke , Brach Mirjam , Stucki Gerold , Rubinelli Sara 
Published: March 2020

BackgroundTechnological solutions, particularly mobile health (mHealth), have been shown to be potentially viable approaches for sustaining individuals’ self-management of chronic health conditions. Theory-based interventions are more successful, as evidence-based information is an essential prerequisite for appropriate self-management. However, several reviews have shown that many existing mobile apps fail to be either theoretically grounded or based on evidence. Although some authors have attempted to address these two issues by focusing on the design and development processes of apps, concrete efforts to systematically select evidence-based content are scant.ObjectiveThe objective of this study was to present a procedure for the participatory identification of evidence-based content to ground the development of a self-management app.MethodsTo illustrate the procedure, we focused on the prevention and management of pressure injuries (PIs) in individuals with spinal cord injury (SCI). The procedure involves the following three steps: (1) identification of existing evidence through review and synthesis of existing recommendations on the prevention and self-management of PIs in SCI; (2) a consensus meeting with experts from the field of SCI and individuals with SCI to select the recommendations that are relevant and applicable to community-dwelling individuals in their daily lives; and (3) consolidation of the results of the study.ResultsIn this case study, at the end of the three-step procedure, the content for an mHealth intervention was selected in the form of 98 recommendations.ConclusionsThis study describes a procedure for the participatory identification and selection of disease-specific evidence and professional best practices to inform self-management interventions. This procedure might be especially useful in cases of complex chronic health conditions, as every recommendation in these cases needs to be evaluated and considered in light of all other self-management requirements. Hence, the agreement of experts and affected individuals is essential to ensure the selection of evidence-based content that is considered to be relevant and applicable.
Development and Performance of a Web-Based Tool to Adjust Urine Toxicology Testing Frequency: Retrospective Study
Authors: Chapman Kenneth B , Pas Martijn M , Abrar Diana , Day Wesley , Vissers Kris C , van Helmond Noud 
Published: March 2020

BackgroundSeveral pain management guidelines recommend regular urine drug testing (UDT) in patients who are being treated with chronic opioid analgesic therapy (COAT) to monitor compliance and improve safety. Guidelines also recommend more frequent testing in patients who are at high risk of adverse events related to COAT; however, there is no consensus on how to identify high-risk patients or on the testing frequency that should be used. Using previously described clinical risk factors for UDT results that are inconsistent with the prescribed COAT, we developed a web-based tool to adjust drug testing frequency in patients treated with COAT.ObjectiveThe objective of this study was to evaluate a risk stratification tool, the UDT Randomizer, to adjust UDT frequency in patients treated with COAT.MethodsPatients were stratified using an algorithm based on readily available clinical risk factors into categories of presumed low, moderate, high, and high+ risk of presenting with UDT results inconsistent with the prescribed COAT. The algorithm was integrated in a website to facilitate adoption across practice sites. To test the performance of this algorithm, we performed a retrospective analysis of patients treated with COAT between June 2016 and June 2017. The primary outcome was compliance with the prescribed COAT as defined by UDT results consistent with the prescribed COAT.Results979 drug tests (867 UDT, 88.6%; 112 oral fluid testing, 11.4%) were performed in 320 patients. An inconsistent drug test result was registered in 76/979 tests (7.8%). The incidences of inconsistent test results across the risk tool categories were 7/160 (4.4%) in the low risk category, 32/349 (9.2%) in the moderate risk category, 28/338 (8.3%) in the high risk category, and 9/132 (6.8%) in the high+ risk category. Generalized estimating equation analysis demonstrated that the moderate risk (odds ratio (OR) 2.1, 95% CI 0.9-5.0; P=.10), high risk (OR 2.0, 95% CI 0.8-5.0; P=.14), and high risk+ (OR 2.0, 95% CI 0.7-5.6; P=.20) categories were associated with a nonsignificantly increased risk of inconsistency vs the low risk category.ConclusionsThe developed tool stratified patients during individual visits into risk categories of presenting with drug testing results inconsistent with the prescribed COAT; the higher risk categories showed nonsignificantly higher risk compared to the low risk category. Further development of the tool with additional risk factors in a larger cohort may further clarify and enhance its performance.
A User-Friendly, Web-Based Integrative Tool (ESurv) for Survival Analysis: Development and Validation Study
Authors: Pak Kyoungjune , Oh Sae-Ock , Goh Tae Sik , Heo Hye Jin , Han Myoung-Eun , Jeong Dae Cheon , Lee Chi-Seung , Sun Hokeun , Kang Junho , Choi Suji , Lee Soohwan , Kwon Eun Jung , Kang Ji Wan , Kim Yun Hak 
Published: March 2020

Background
Prognostic genes or gene signatures have been widely used to predict patient survival and aid in making decisions pertaining to therapeutic actions. Although some web-based survival analysis tools have been developed, they have several limitations.

Objective
Taking these limitations into account, we developed ESurv (Easy, Effective, and Excellent Survival analysis tool), a web-based tool that can perform advanced survival analyses using user-derived data or data from The Cancer Genome Atlas (TCGA). Users can conduct univariate analyses and grouped variable selections using multiomics data from TCGA.

Methods
We used R to code survival analyses based on multiomics data from TCGA. To perform these analyses, we excluded patients and genes that had insufficient information. Clinical variables were classified as 0 and 1 when there were two categories (for example, chemotherapy: no or yes), and dummy variables were used where features had 3 or more outcomes (for example, with respect to laterality: right, left, or bilateral).

Results
Through univariate analyses, ESurv can identify the prognostic significance for single genes using the survival curve (median or optimal cutoff), area under the curve (AUC) with C statistics, and receiver operating characteristics (ROC). Users can obtain prognostic variable signatures based on multiomics data from clinical variables or grouped variable selections (lasso, elastic net regularization, and network-regularized high-dimensional Cox-regression) and select the same outputs as above. In addition, users can create custom gene signatures for specific cancers using various genes of interest. One of the most important functions of ESurv is that users can perform all survival analyses using their own data.

Conclusions
Using advanced statistical techniques suitable for high-dimensional data, including genetic data, and integrated survival analysis, ESurv overcomes the limitations of previous web-based tools and will help biomedical researchers easily perform complex survival analyses.