bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applicability of logistic regression with sum-to-zero constraint parameterization in risk assessment for parotid malignancy
Authors: Cayetano Shari Messinger , Lo Kaming , Fundakowski Christopher , Sargi Zoukaa 
Published: November 2019

Abstract
Background Investigative interest is often to determine how results from a diagnostic tool change the patient’s risk of disease with respect to the overall(naïve) risk at clinical presentation. Logistic regression is popular for data analysis for this type of investigation. However, standard approach, which uses reference cell coding, may not be informative in this setting. This is because this approach compares the risk between two distinct groups.Methods We considered weighted and unweighted approaches to model parameterization using deviation from means coding for assessing the risk of parotid malignancy, comparing patients with indeterminate fine-needle aspiration biopsy(FNAB) results with the general(naïve) risk among all presenting patients. Results from deviation from means coding and standard reference cell coding were compared.Results Unweighted coding estimates a two-fold increase in the odds of malignancy with an indeterminate FNAB result compared to the naïve odds at clinical presentation (Odds ratio(OR): 1.97 [95% Confidence Interval(CI): 1.34–2.90], P=0.0006). The weighted approach estimates increased risk (OR: 2.38 [95% CI: 1.45 – 3.89], P=0.0006), more accurately representing the naïve risk at presentation based on the direction of sample imbalance in the study. Using standard reference cell coding, an indeterminate result has a higher risk compared to a negative result, but this does not inform us about the risk with respect to that inherent at clinical presentation.Conclusions Depending on the investigative interest, it is important to adopt the appropriate coding methodology when logistic regression is applied. In addition, a weighted approach should be considered to account for sample imbalance.
Development and validation of a UPLC-MS method for determination of atazanavir sulfate by the “analytical quality by design” approach
Authors: Saha Chandni , Gupta N. Vishal , Chandan R. S. 
Published: November 2019

Abstract
A UPLC-MS method for the estimation of atazanavir sulfate was developed using the “analytical quality by design” approach. The critical chromatographic quality attributes identified were retention time, theoretical plates and peak tailing. The critical method parameters established were percent of organic modifier, flow rate and injection volume. Optimization performed using Box-Behnken Design (BBD) established 10 % organic modifier, 0.4 mL min−1 flow rate and 6-µL injection volume as the optimum method conditions. Atazanavir sulfate eluted at 5.19 min without any interference. Method validation followed international guidelines. The method has proven linearity in the range of 10–90 µg mL−1. Recovery was between 100.2–101.0 % and precision within the accepted limits (RSD 0.2–0.7 %). LOD and LOQ were 2.68 and 8.14 µg mL−1, resp. Stress testing stability studies showed atazanavir sulfate to degrade under acidic and basic conditions. The suggested technique is simple, rapid and sustainable. It is, therefore, suggested for routine analysis of atazanavir sulfate.
Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and dry-coated tablets
Authors: Vlachou Marilena , Geraniou Efthymia , Siamidi Angeliki 
Published: November 2019

Abstract
Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release. With this in view, we aimed at achieving furosemide’s longer gastric retention and waste minimization by preparing matrix and compression coated tablets incorporating different grades of Eudragit® and poly(ethylene oxide) (PEO), polyvinylpyrrolidone (PVP) and lactose monohydrate. Dissolution profiles of the new formulations were compared with that of the main stream drug Lasix®, 40 mg tablets. The results indicate that the use of Eudragit® in conjunction with either PVP or lactose monohydrate led to a slower release rate in the intestinal fluids compared to Lasix®. Moreover, furosemide release in the intestinal pH from matrix tablets and compression coated tablets was not noticeably different. Formulations incorporating PEO led to sustained release, in intestinal fluids, which depended on the molecular weight of PEO.
TLC-densitometric analysis of allantoin in Symphytum officinale L. roots
Authors: Kimel Katarzyna , Zienkiewicz Magdalena , Sparzak-Stefanowska Barbara , Krauze-Baranowska Mirosława 
Published: November 2019

Abstract
A TLC-densitometric method for determination of allantoin in Symphytum officinale root was developed. Densitometric quantification of allantoin was carried out on TLC Si60 plates with butanol-50 % methanol/formic acid, 66.5:33.2:0.3 (V/V/V) as developing solvent, at a wavelength of 190 nm. The method was preliminarily validated in terms of specificity, linearity, precision, limit of detection, limit of quantification, recovery and robustness. The results of TLC quantification were compared with HPLC analysis carried out on a HILIC Luna NH2 100A column, with mobile phase consisting of acetonitrile/water 80:20 (V/V) and UV detection at 190 and 210 nm. Allantoin content was determined in two herbal products and it varied from 0.94 to 2.09 %, depending on the producer, and was in agreement with literature reports.
Identification of Study Sites for Placement of Sediment Traps in Vegetated Buffer Strips
Authors: Pöppl Ronald , Aydin Elena 
Published: November 2019

Abstract
The aim of this contribution was to outline the decision procedure for selecting potential sites suitable for installing sediment traps in vegetation buffer strips in the Fugnitz catchment, Austria. The selection procedure consisted of GIS data processing where the contributing areas of specific sites were specified according to the selected criteria (i.e. slope above 2°, vegetation strip in between agriculturally used land and river network, contributing area of at least 300 m2). Available landuse maps were updated with formerly not-digitized structures potentially influencing connectivity (e.g. ephemeral streams and road ditches) which were mapped in the field. From 31 pre-defined sites 15 were selected, taking into account as additional selection criteria the slope angle, soil erodibility and size of the contributing area. Two sites were selected for further investigations – i.e. installation of the sediment traps in vegetation filter strips collecting event-based sediment yields from adjacent arable fields. We conclude that GIS analysis has shown to be useful for the first step-delineation of potential sites of interest on the catchment scale. However, field-based surveys have been shown to be inevitable to obtain on-site information on vegetation characteristics and fine-scale topographic and management information.
Impact Assessment of Vegetation Growth on Soil Erosion of a Landfill Cover Surface
Authors: Shaikh Janarul , Yamsani Sudheer Kumar , Bora Manash Jyoti , Sekharan Sreedeep , Rakesh Ravi Ranjan , Mungale Atharva , Bordoloi Sanandam 
Published: November 2019

Abstract
Soil erosion is a very common phenomenon encountered at many sloped earthen geotechnical structures. For instance, the surface soil of an inclined landfill cover system undergoes the erosion due to various adverse atmospheric variants. This is one of the major causes for performance failure in the cover system. However, previous researchers have rarely conducted the study for field assessment of soil erosion in high rainfall tropical regions such as northeast India. The literature advocates the utilization of vegetation for erosion management. This study investigated the impact of vegetation growth on soil erosion of a cover surface layer under both natural and controlled artificial rainfall. The soil erosion was monitored by collecting the soil loss due to rainfall. Vegetation growth was evaluated based on photographic image analyses. The study clearly indicates that the vegetation growth can contribute to reduction of soil erosion from the landfill cover surface.
Movement of the Suspended Flow in the Open Irrigation Channels
Authors: Arifjanov Aybek , Fatxulloev Alisher , Kaletová Tatiana 
Published: November 2019

Abstract
The article deals with the issues of turbulent movement of a suspended flow in open channels. Differential equations of a suspended flow were used with considering the interaction of the fluid and solid particles. The solution of equations for steady flow was obtained by a numerical method. Field data measured in irrigation channels in Tashkent and Parkent were used to estimate the velocity distribution over the depth of the stream. Developed method for calculating the formation of velocity field in statically and dynamically stable channels considered the turbulent characteristics and the presence of suspended sediments in the stream. The possibilities of practical application of the above-mentioned differential equations to the solution of the problem of a suspended solids flow's forming a velocity field were discussed. The developed analytical formulas make it possible to determine the value of flow parameters. The result is a new generalization of the mathematical model of the velocity field formation regularity at different flow saturations with a suspension. On its basis, the method is developed for calculating the parameters of the weighing process and transport of suspended particles in open channels.
Prediction of Sewing Thread Consumption for Over-Edge Stitches Class 500 Using Geometrical and Multi-Linear Regression Models
Authors: Sarah Malek , Adolphe Dominique C. , Boubaker Jaouachi 
Published: November 2019

Abstract
Rapid and precise methods (geometrical and statistical), which aim to predict the amount of sewing thread needed to sew a garment using different over-edge stitches of class 500 (501, 503, 504, 505, 512, 514, 515, and 516), have been provided. Using a geometrical method of different over-edge stitch shapes, sewing consumption value was determined to avoid the unused stocks for each stitch type. The prediction of the sewing thread consumption relative to each investigated over-edge stitch was proposed as a function of the studied input parameters, such as material thickness, stitch density, yarn diameter, and seam width (distance between the needle and the cutter and the distance between two needles). To improve the established models using a geometrical method, a statistical method based on multi-linear regression was studied. Geometrical and statistical results were discussed, and the coefficient R2 value was determined to evaluate the accuracy of the tested methods. By comparing the estimated thread consumption with the experimental ones, we concluded that the geometrical method is more accurate than the statistical method regarding the range of R2 (from 97.00 to 98.78%), which encourages industrialists to use geometrical models to predict thread consumption.
All studied parameters contributing to the sewing thread consumption behavior were investigated and analyzed in the experimental design of interest. It was concluded that the most important parameter affecting thread consumption is the stitch density. The material thickness and the seam width (B1) have a little impact on thread consumption values. However, the seam thread diameter has a neglected effect on thread consumption.
Real Estate Entrepreneurial Training and Education in Tertiary Institution: An Antidote to Unemployment
Authors: Anih Paul C. , Nissi Chicheta F. , Akpan Uduakobong E. 
Published: November 2019

Abstract
Real estate entrepreneurship training and education in tertiary institutions can be a source of remedy to unemployment in Nigeria. World Bank (2019) reveals that Nigeria unemployment rate was 6.03 % in the year 2018 and the country ranked 83rd with high unemployment. The aim of the research is to examine the perception and responses of undergraduates of Estate Management and Valuation on entrepreneurship training and education for professional competence. The University of Uyo was studied and particularly Estate Management undergraduates during the academic years of 2014/2015–2018/2019. The method of the research was a descriptive study. Data were obtained from the mean scores of the class assessments (CAs) and the examination scores (ESs) administered to the students on selected courses related to entrepreneurial education. The students’ performance was used as an indicator for their willingness to adhere to entrepreneurial education in Real Estate Management and Valuation. The National Universities Commission grading scale was adopted (A = 70–100; B = 60–69; C = 50–59; D = 45–49; E = 40–44; F = 0–39). The finding shows that the score for all the courses was above 50 %. The entrepreneurial study was 62 %, which was “B” grade of National Universities Commission scale. The study, therefore, concludes that the students of estate management were willing to adhere to entrepreneurial training and education from their scores. The study recommends the provision of adequate learning environment, qualified teaching staff and provision of technical resources.
Go to the city: urban invasions of four pipistrelle bat species in eastern Slovakia
Authors: Nusová Gréta , Uhrin Marcel , Kaňuch Peter 
Published: November 2019

Abstract
Until now, late summer or autumn invasions into inhabited building have been regarded as phenomenon typical for the common pipistrelle, pipistrellus pipistrellus, exclusively. During the investigation of this phenomenon in the city of Košice (eastern Slovakia), we discovered that it was not always entirely specific for this species. During the period 2016–2018, we recorded 3 events out of 35 invasions, where small groups of common pipistrelles that invaded into inhabited buildings were also accompanied by individuals of two con-generic bat species, pipistrellus pygmaeus and pipistrellus kuhlii. Cryptic species p. pipistrellus and p. pygmaeus were determined by genetic test. In addition, in 2019, we recorded the first winter occurrence of another pipistrelle species, pipistrellus nathusii, in this urban environment. We conclude that areas of frequent invasive behaviour of p. pipistrellus may be sometimes associated with concomitant occurrence of other related species that share common thermal or foraging niche and such behaviour could be evidence of their urbanisation tendencies.
Thrombocytopenia and Coronary Artery Disease, the Existing Dilemmas
Authors: Davarashvili Ilia , Hasin Tal , Asher Elad 
Published: November 2019

Abstract

Background: Platelets play a pivotal role in the pathogenesis of acute coronary syndrome (ACS) and acute or chronic complications following percutaneous coronary intervention (PCI) as well. Platelet inhibition is a cornerstone treatment in the management of these patients. Thrombocytopenia in patients with ACS is uncommon. Idiopathic thrombocytopenic purpura (ITP) is a rare phenomenon; nevertheless, some case series presenting concomitant ACS and ITP have been described in the literature. The safety of antiplatelet therapy and PCI in patients who have ACS and thrombocytopenia is limited.

Case summary: We present a case of a 60-year-old patient with ITP who was admitted with unstable angina pectoris. On admission, the platelet count was 23 × 109/L. Coronary CT angiography revealed severe stenosis in the mid portion of RCA. After one-week treatment with high-dose Prednisolone, the platelet count recovered, and coronary catheterization was performed. Successful PCI to the RCA with drug-eluting stent was performed. The patient was discharged on dual antiplatelet therapy.

Conclusion: The case suggests that PCI is a suitable treatment for ITP patients with ACS. Hemostasis is the major concern in managing these patients. The treatment strategy may be based on platelet function rather than platelet count alone. Further analysis of antiplatelet therapies as mono or dual therapy are needed.
A Guitaring Technique with 035 Wire and Perforated Coronary Balloon for Thrombolysis in the Treatment of Acute Deep Vein Thrombosis
Authors: Arokiaraj Mark Christopher 
Published: November 2019

Abstract
A patient who underwent thrombolysis and inferior vena cava filter implantation for acute deep vein thrombosis treatment nine years before, presented with deep vein thrombosis on the other limb. The venous angiogram showed deep vein thrombosis in the ilio-femoral vessels. Through left femoral vein puncture, a 6F right Judkins diagnostic catheter was advanced up to the proximal iliac veins, and further advancement was not possible. Hence, a 035 hydrophilic wire was advanced, and through a guitaring technique, the clots were disrupted at the mid-thigh level. Through a 014 coronary wire, a punctured coronary balloon was placed at the distal mid-thigh level, and intravascular thrombolysis was performed for 12 hours, followed by removal of the balloon and the right coronary Judkins catheters. The leg swelling reduced in the first day, and subsequently, the patient was followed up for 7 months with anticoagulation and good resolution of the symptoms.
Sign System Studies and Modern Socio-Anthropomorphism
Authors: Sukhoverkhov Anton Vladimirovich 
Published: November 2019

Abstract
The article examines the individual and social, practical, and theoretical presumptions (“idols” and “beliefs”) that constitute the conscious and unconscious re-construction of the social reality and reality of different conventional sign systems that represent and are represented by society. It is shown that in everyday life and in theoretical studies, we quite often analyze sign systems as if they were autonomous and empirically “given” realities. The work explains how this “natural belief” originated and developed. It is argued that conventional sign systems cannot be reduced to the reality of material “sign vehicles” because in society, sign systems are both subjective and objective, internal and external, and process and object.
Landscape evolution in the area of Kazimierski Landscape Park
Authors: Sobczyński Daniel , Karsznia Izabela 
Published: November 2019

Abstract
The presented research concerning the landscape evolution of the area of the Kazimierski Landscape Park assumed the analysis of landscape changes that took place in the western part of the Nałęczów Plateau in eastern Poland as a result of increased anthropopressure. To achieve this goal, the diverse data was employed: archives of the “Archeological Survey of Poland” obtained from the National Heritage Board of Poland, the registry data from the 16th century made available as part of the “Atlas Fontium” project elaborated by the Institute of History of the Polish Academy of Sciences, old map of the Western Galicia from 1808, a tactical map of the Military Geographical Institute in Warsaw from 1937, and the “Topographic Objects Database” (BDOT10k) obtained from the Head Office of Geodesy and Cartography. Based on the analysed data, maps presenting the development of the settlement network from the moment of permanent settlement of the area up to the present state and maps showing the changes in land use in the Kazimierski Landscape Park over the last centuries have been designed.
The results of historical and geographical analyses carried out as part of the research were compared with the results of geomorphological research conducted in the studied area. Verification of the obtained results allowed to determine the scope in which man influenced the evolution of the landscape of the analysed area, including its diversification depending on the historical period and the type of the economy. The process of georeferencing the map of Western Galicia elaborated by colonel A.M. von Heldensfeld from 1808 and the tactical map 1:100,000 of Military Geographical Institute from 1937 covering the research area (14,974 ha) was carried out in the ArcGIS Desktop software. The calibration process was evaluated in the Map Analyst program which makes it possible to analyze the distortions of old maps. Then, vectorization of selected terrain coverage classes and visualization of spatial data were conducted. This way, the land use maps were analyzed in terms of environmental changes that occurred over the past centuries by identifying the areas with the largest development changes. The obtained results were compared with the database of historical objects created for the purposes of this research, based on data provided by the National Heritage Board of Poland and the Institute of History of the Polish Academy of Sciences in order to determine the development trends of the settlement network in the region. The additional statistical analysis made it possible to determine the trend of changes and to interpret the distribution of areas threatened by the occurrence of mass movements with the analyzed anthropogenic determinants.
Association of Human Parvovirus B19 Infection with Development and Clinical Course of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
Authors: Rasa-Dzelzkalēja Santa , Čapenko Svetlana , Krūmiņa Angelika , Lin Yung-Cheng , Murovska Modra 
Published: November 2019

Abstract
Our aim was to estimate the presence of B19V infection markers, the level of cytokines and time period since the appearance of infection in association with ME/CFS clinical symptoms. In 200 ME/CFS patients and 104 control group individuals the presence of B19V-specific IgG/IgM class antibodies, B19V NS1 gene sequence, mRNA expression, viral load and level of cytokines were determined. B19V-specific IgG-antibodies were found in 70% of ME/CFS patients and 67.4% of controls, IgM-antibodies in 8% of patients and in none of controls, B19V genomic sequences in 29% of patients and 3.8% of controls. 58.6% of positive patients had active and 41.4% had latent/persistent B19V infection. B19V NS1 gene expression was detected in 43% of patients. B19V load varied from < 0.2 copies to median 38.2 copies/µg of DNA. According to the antibody pattern, 36% of patients had a recent, and 43% had sustained B19V infection. Patients with the B19V genomic sequence and NS1 specific antibodies significantly more often had lymphadenopathy and multi-joint pain. Onset of the symptoms corresponded to time of appearance of B19V infection. IL-10 and TNF-levels were higher in patients with elevated B19V load. B19V genome 1 was identified in Latvian ME/CFS patients. The results indicated that at least in some cases B19V infection plays an important role in ME/CFS development