bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, characterization, and investigation of the anti-inflammatory effect of 2,3-disubstituted quinazoline-4(1H)-one
Authors: Ghodge Bhimrao , Kshirsagar Ajay , Navghare Vijay 
Published: August 2020

Abstract
Background
Quinazolin-4(1H)-one nucleus has attracted the attention of medicinal chemists due to their clinical uses. Modification of quinazolinone ring for the development of pharmaceutical and clinical compound for its anti-inflammatory potential.

Results
In vitro anti-inflammatory activity of the synthesized compounds was performed by using egg albumin protein denaturation assay, while in vivo anti-inflammatory activity was performed by using carrageenan-induced rat paw edema and cotton pellet-induced granuloma pouch model.
In the present study, we synthesized a new series of 2,3-disubstituted quinazolin-4(1H)-one derivatives and evaluated their in vivo, in vitro anti-inflammatory effect. Their chemical structures are confirmed by FTIR, 1HNMR, and mass spectrum. Among all the synthesized compounds, G1 and G3 exhibit the significant anti-inflammatory activity by inhibiting release of inflammatory mediators like prostaglandin, histamine, and serotonin. in both in vivo and in vitro models as compared to compound G2.

Conclusion
These synthesized compounds showed anti-inflammatory activity by inhibiting prostaglandins and COX enzymes. So, all test compounds may be used for both inflammation as well as inflammation-induced cancer therapy. Future various screening method related with inflammation and inflammation-induced cancer needs to be evaluated pre-clinically and clinically.
Normal active range of motion of lower extremity joints of the healthy young adults in Cairo, Egypt
Authors: Abu El Kasem Shimaa T. , Aly Sobhy M. , Kamel Ehab M. , Hussein Hisham M. 
Published: August 2020

AbstractBackgroundRange of motion (ROM) can be considered as one of the most commonly measured variables in musculoskeletal health care. When interpreting ROM, a common method is to compare obtained ROM values to normative data. So the current study aimed to establish (1) normative active ROM (AROM) values for lower extremity joints in young Egyptian adults, (2) compare the AROM between dominant and non-dominant lower extremity joints, and (3) compare between the values of AROM of lower extremity joints in both genders.ResultsPairedt-test demonstrated that there was statistical but not a clinical difference between the dominant and non-dominant ROM values of the lower extremity joints. Unpairedt-test revealed that there was statistical but not a clinical difference between male and female ROM values of lower extremity joints.ConclusionsThis study summarized normative data of Egyptian young adults; there were statistical but not a clinical difference between dominant and none dominant lower extremity joints in AROM and between males and females.
Increased Body Mass Index Is Associated With A Nondilutional Reduction in Antimüllerian Hormone
Authors: Jaswa Eleni Greenwood , Rios Julie S , Cedars Marcelle I , Santoro Nanette F , Pavone Mary Ellen G , Legro Richard S , Huddleston Heather G 
Published: August 2020

Abstract

Context
Controversy exists regarding if and how body mass index (BMI) impacts antimüllerian hormone (AMH) in women with and without polycystic ovary syndrome (PCOS). Understanding the BMI-AMH relationship has critical implications for clinical interpretation of laboratory values and could illuminate underlying ovarian physiology.

Objective
To test the hypotheses that (1) BMI is associated with reduced AMH in PCOS and ovulatory controls (OVAs) and (2) the reduction in AMH is not accounted for by dilutional effects.

Design/Setting
Multicenter cohort.

Participants
Women aged 25 to 40 years from 2 clinical populations: 640 with PCOS, 921 women as OVAs.

Main Outcome Measures
Ovarian reserve indices: AMH, antral follicle count (AFC), and AMH to AFC ratio (AMH/AFC) as a marker of per-follicle AMH production.

Results
In both cohorts, increasing BMI and waist circumference were associated with reductions in AMH and AMH/AFC, after adjusting for age, race, smoking, and site in multivariate regression models. Increasing BMI was associated with reduced AFC in PCOS but not OVAs. Body surface area (BSA), which unlike BMI is strongly proportional to plasma volume, was added to investigate a potential dilutive effect of body size on AMH concentrations. After controlling for BSA, BMI retained independent associations with AMH in both cohorts; BSA no longer associated with AMH.

Conclusions
In an adjusted analysis, BMI, but not BSA, was associated with reduced AMH; these data do not support a role for hemodilution in mediating the relationship between increased body size and reduced AMH. Decreased AMH production by the follicle unit may be responsible for reduced AMH with increasing BMI.
The association between carotid calcium on dental panoramic radiographs and coronary calcium score on chest computerized tomography
Authors: Carasso Shemy , Porat Ben Amy Dalit , Issawy Mariana , Kusniec Fabio , Ghanim Diab , Sudarsky Doron , Elbaz-Greener Gabby , Kinany Wadi , Shmuel Chen , Abu El-Naaj Imad , Kachel Erez , Amir Offer 
Published: August 2020

Objectives: Coronary artery calcium measured by CT predicts future coronary events. Similarly, carotid artery calcium on dental panoramic radiographs has been associated with increased cardiovascular events. Pre-procedural assessment of candidates for valve replacement in our institution includes panoramic radiographs and chest tomography. We aimed to assess the association of carotid calcium on panoramic radiographs with coronary artery calcium on chest tomography. Methods: Paired pre-procedural panoramic radiographs and chest tomography scans were done in 177 consecutive patients between October 2016 and October 2017. Carotid calcium was quantified using NIH’s ImageJ. Coronary artery calcium was quantified by the Agatston score using Philips Intellispace portal, v. 8.0.1.20640. Results: Carotid calcium maximal intensity, area and perimeter were higher among patients with high coronary artery calcium. Non-zero carotid calcium was found in half of patients with high coronary artery calcium, doubling prevalence of low coronary artery calcium. Conclusion: Carotid calcium identified in panoramic radiographs was associated with high coronary artery calcium. Awareness of carotid calcium recognized by dental practitioners in low-cost, low radiation and commonly done panoramic radiographs may be useful to identify patients at risk of coronary disease with potential future cardiovascular events.
Communicative Culture of Teachers and Parents As a Condition for the Upbringing of Freedom in Children's Behavior
Authors: Arnautova E. , Vorob'eva I. , Rychagova Elena 
Published: August 2020

This article emphasizes the correlation between the communicative culture of adults (teachers and parents) and cultivation of freedom in preschool children’s behavior. The first part of the article is devoted to the pedagogical approaches to development of preschool children's communicative ways of speech communication. Among the methods of dialogical speech development there are communicative games, verbal didactic games with pair interaction and problematic situations. The communicative content of these games is realized through the child's implementation of certain game rules, which are perceived as rules of communication. This part discovers the effectiveness of playing out communicative situations as a method to master children’s culture of communication with their peers. The relations of full-fledged communication and cooperation require a significant renewal of children's life organization in kindergarten, and conditions for free communication, without any instructions, for the emancipation of the child's and the adult's personalities.
The article shows the possibilities of children’s artistic activity for their dialogical communication with peers and teacher. It considers the features of organizing creative artistic activities when children create their own product (drawing, modeling, application, DIY) and wonder the opinion of other people – adults and children. This discussion differs from everyday dialogue in its content, since it has an artistic focus on the perception of art and creative activity. It is shown that communication during joint creativity of children arises due to an objective situation and a desire of children to cooperate, co-creation and empathy.
The final part of the article is related to the content of experimental work to support the communicative culture of teachers and parents as the first transmitters of healthy communication experience to children. It examines domestic and foreign communication models that are most effective in working with teachers and parents of preschool children. The important elements of communication are explained accompanied by examples. Such support includes not only the level of verbal communication, but also a certain type of contact between an adult and a child: emotional, motional, gaming.
Metode Biblioterapi Islam Untuk Pengembangan Karakter Tanggung Jawab Pada Mahasiswa
Authors: Shofiah Vivik 
Published: August 2020

AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh metode biblioterapi Islam dalam meningkatkan karakter tanggung jawab pada mahasiswa. Subjek dalam penelitian ini berjumlah 11 mahasiswa fakultas psikologi UIN Sultan Syarif Kasim Riau yang terbagi menjadi enam (6) mahasiswa menjadi kelompok eksperimen dan lima (5) mahasiswa menjadi kelompok kontrol. Penelitian ini menggunakan desain nonequivalent control group design. Data penelitian diperoleh dengan menggunakan skala karakter tanggung jawab dan di analisis dengan menghitung rerata gain skor kelompok eksperimen dan kelompok kontrol. Berdasarkan uji hiptesis diperoleh hasil bahwa rerata gain skor pada kelompok eksperimen (-7,14) lebih tinggi dibanding dengan kelompok kontrol (-0,58). Artinya metode biblioterapi islam berpengaruh terhadap pengembangan karakter tanggung jawab pada mahasiswa. Kata Kunci : biblioterapi islam, karakter, tanggung jawab.
Studi Eksplorasi Keberfungsian Full Day School Bagi Orangtua dan Anak pada SDIT Muhammadiyah 019 Bangkinang Kampar
Authors: Ratnani Indah Puji , Unthe Ricca Angreini 
Published: August 2020

ABSTRAKSekolah full day menjadi sesuatu yang menarik perhatian masyarakat, terutama bagi orangtua. Sistem full day school menawarkan berbagai macam keuntungan bagi orangtua yang bekerja namun tetap menginginkan anak mendapatkan pendidikan maksimal. Kenyataanya, tidak semua anak merasakan dampak positif dan kenyamanan dari sistem full day yang diberlakukan tersebut. Penelitian ini bertujuan untuk mengetahui keberfungsian Full Day School Bagi Orangtua dan Anak Pada SDIT Muhammadiyah 019 Bangkinang Kampar yang memiliki kelas Tahfiz sebagai program unggulan. Penelitian ini adalah penelitian kualitatif deskriptif dengan reduksi data, penyajian data dan penarikan kesimpulan. Data diperoleh dari hasil wawancara, observasi dan dokumentasi. Responden dalam penelitian ini adalah satu orang kepala sekolah, tiga orang guru, dua puluh wali murid dan dua puluh lima siswa kelas tahfiz. Hasil penelitian menunjukkan bahwa anak dan orang tua sama-sama merasakan manfaat dari full day school. Anak merasakan perasaan senang dan bahagia. Orang tua merasakan perubahan akhlak dan prestasi akademik anak semakin baik setelah mengikuti full day school. Keyword : Full day School, Orangtua, anak, SD IT
Mucosa-Associated Microbiota in Barrett's Esophagus, Dysplasia, and Esophageal Adenocarcinoma Differ Similarly Compared With Healthy Controls
Authors: Peter Shajan , Pendergraft Amanda , VanDerPol William , Wilcox C. Mel , Kyanam Kabir Baig Kondal R. , Morrow Casey , Izard Jacques , Mannon Peter J. 
Published: August 2020

INTRODUCTION:
Alterations in the composition of the human gut microbiome and its metabolites have been linked to gut epithelial neoplasia. We hypothesized that differences in mucosa-adherent Barrett's microbiota could link to risk factors, providing risk of progression to neoplasia.

Methods:
Paired biopsies from both diseased and nonaffected esophagus (as well as gastric cardia and gastric juice for comparison) from patients with intestinal metaplasia (n = 10), low grade dysplasia (n = 10), high grade dysplasia (n = 10), esophageal adenocarcinoma (n = 12), and controls (n = 10) were processed for mucosa-associated bacteria and analyzed by 16S ribosomal ribonucleic acid V4 gene DNA sequencing. Taxa composition was tested using a generalized linear model based on the negative binomial distribution and the log link functions of the R Bioconductor package edgeR.

Results:
The microbe composition of paired samples (disease vs nondisease) comparing normal esophagus with intestinal metaplasia, low grade dysplasia, high grade dysplasia, and adenocarcinoma showed significant decreases in the phylum Planctomycetes and the archaean phylum Crenarchaeota (P < 0.05, false discovery rate corrected) in diseased tissue compared with healthy controls and intrasample controls (gastric juice and unaffected mucosa). Genera Siphonobacter, Balneola, Nitrosopumilus, and Planctomyces were significantly decreased (P < 0.05, false discovery rate corrected), representing <10% of the entire genus community. These changes were unaffected by age, tobacco use, or sex for Crenarcha.

DISCUSSSION:
There are similar significant changes in bacterial genera in Barrett's esophageal mucosa, dysplasia, and adenocarcinoma compared with controls and intrapatient unaffected esophagus. Further work will establish the biologic plausibility of these specific microbes' contributions to protection from or induction of esophageal epithelial dysplasia.
Experience with cladribine tablets for highly active multiple sclerosis in everyday clinical practice
Authors: Petrov S. V. , Boyko O. V. , Boyko A. N. 
Published: August 2020

Cladribine tablets are a new drug for the immune reconstitution therapy of highly active multiple sclerosis (HAMS). After discussing the characteristics of action of the drug in clinical trials, the authors give their own experience of its use in the Moscow Multiple Sclerosis Center.Objective: to assess their own experience with cladribine tablets in the treatment of HAMS patients in everyday clinical practice.Patients and methods: In 2018–2020, a total of 14 patients with HAMS and an average exacerbation frequency of 2.42 per year (34 exacerbations) received a full cycle of cladribine therapy. The patients independently purchased the drug for individual indications. Prior to starting therapy and every subsequent 6 months, all the patients underwent contrast-enhanced magnetic resonance imaging (MRI) of the brain, cervical and thoracic spine, and chest X-ray, Expanded Disability Status Scale (EDSS) scoring, clinical blood analysis, lymphocyte subpopulation estimation, biochemical blood analysis. The levels of leukocytes, lymphocytes, and lymphocyte subpopulations were estimated after one- and two-year cladribine tablet therapy cycles.Results and discussion. During a two-year cladribine tablet therapy cycle, there were only 2 exacerbations (0.1 per year); the EDSS values stabilized, while they slightly decreased; according to MRI, the number of foci declined substantially from 78 (an average of 3.12 per image) before treatment to 6 (an average of 0.2 per image) after 2 years of treatment. No serious adverse events were recorded in patients taking cladribine tablets. By the end of the first year of treatment, the level of lymphocytes returned to normal in all the patients. The similar picture was noted after the second cycle of therapy. More than two-thirds of patients showed a decline in CD19+ B lymphocytes. An anti-B-cell effect was recorded even in patients who had normal absolute lymphocyte counts, as shown by clinical blood analysis. The findings demonstrated the efficacy and safety of cladribine tablets in patients with HAMS.Conclusion. Cladribine tablets are a highly effective treatment for HAMS.
FAKTOR SOCIAL EKONOMI DAN PERSEPSI PENGRAJIN TEMPE DALAM PENGGUNAAN BAHAN BAKU KEDELA (STUDI KASUS DI SENTRA INDUSTRY TEMPE SANAN )
Authors: Yudiono Kukuk , Cahyono Edi Dwi 
Published: August 2020

Tujuan dari penelitian ini adalah untuk: (1) Menganalisis faktor sosial ekonomi yang memengaruhi keputusan pengrajin tempe dalam menggunakan kedelai impor sebagai bahan baku tempe; (2) Mendeskripsikan persepsi pengrajin tempe terhadap jenis kedelai yang digunakan sebagai bahan baku tempe. Metode penelitian dalam penentuan lokasi dilakukan dengan purposive (sengaja) yaitu di sentra industri tempe Sanan, kota Malang. Penentuan responden menggunakan metode sensus dengan jumlah sampel 36 responden. Metode pengumpulan data melalui wawancara, observasi dan dokumentasi. Metode analisis data untuk menjawab tujuan dari penelitian ini adalah analisis regresi berganda dan analisis deskriptif. Hasil penelitian menunjukkan bahwa faktor sosial ekonomi meliputi hasil produksi, harga kedelai, jumlah tenaga kerja dan kwalitas kedelai secara simultan berpengaruh terhadap keputusan pengrajin tempe dalam menggunakan kedelai impor yang ditunjukkan dengan nilai F hitung > F tabel, dimana diperoleh hasil sebesar 79,795 dengan nilai signifikansi (0,000). Analisis regresi berganda faktor sosial ekonomi yang sangat berpengaruh terhadap keputusan pengrajin tempe dalam membuat tempe memiliki nilai koefisien nyata dan signifikansi yang diperoleh 0,000. Persepsi pengrajin tempe terhadap kontinuitas produk dan harga dari jenis kedelai yang digunakan bahwa kedelai impor memberikan pemahaman bahwa pengrajin tempe sangat mudah mendapatkan informasi mengenai pasokan kedelai impor dan harga yang sedang berlaku. Semua pengrajin menggunakan bahan baku kedelai impor berdasarkan persepsi bahwa kedelai impor: a) bijinya besar, b) tempenya lebih mengembang, c) ketersediaan continue, d) harga lebih murah, e) bijinya seragam dan lebih bersih, f) warna cerah, dan mudah mendapatkan informasi baik dari paguyuban atau koperasi.
PENGARUH PERTUMBUHAN KREDIT, EFISIENSI OPERASIONAL, DAN KECUKUPAN MODAL TERHADAP PROFITABILITAS PADA LEMBAGA PERKREDITAN DESA (LPD) DI KECAMATAN BANJARANGKAN, KLUNGKUNG, BALI
Authors: Sukariani Ni Nyoman Ayu Dewi , Ustriyana I Nyoman Gede , Dewi Ida Ayu Listia 
Published: August 2020

Pengembangan Lembaga Perkreditan Desa (LPD) dalam mendukung pembangunan nasional salah satunya adalah melalui LPD Kecamatan Banjarangkan, Klungkung, Bali. Dalam rangka mempertahankan dan meningkatkan kontinuitasnya, LPD juga memerlukan kinerja keuangan yang handal. Hal itu sejalan dengan prinsip keuangan berkelanjutan yang menekankan upaya agar laba usaha atau profitabilitas dapat ditingkatkan.Penelitian ini dilakukan untuk mengetahui pengaruh pertumbuhan kredit (LDR), efisiensi operasional (BOPO), dan kecukupan modal (CAR) terhadap profitabilitas (ROA) LPD di tahun 2015-2017. Teknik penentuan sampel dalam penelitian ini dilakukan secara sensus, dan diperoleh 20 LPD. Teknik analisis yang digunakan adalah analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa pertumbuhan kredit berpengaruh positif dan signifikan terhadap profitabilitas, efisiensi operasional berpengaruh negatif dan signifikan terhadap profitabilitas, dan kecukupan modal berpengaruh negatif dan signifikan terhadap profitabilitas LPD di Kecamatan Banjarangkan, Klungkung Bali periode 2015-2017.
PERANAN PROGRAM SERTIFIKAT UTZ TERHADAP PENINGKATAN PRODUKSI DAN PENDAPATAN PETANI KAKAO DI KABUPATEN JEMBRANA PROVINSI BALI
Authors: Ginting Windi Arihta , Ambarawati Gusti Agung Ayu , Dewi Ida Ayu Listia 
Published: August 2020

Indonesia merupakan penghasil kakao ketiga di dunia. Komoditi kakao Indonesia sangat berpotensi untuk dikembangkan dari segi kuantitas namun dari segi kualitas dinilai masih rendah untuk pasar dunia terutama Eropa. Salah satu program yang dapat mendorong produksi dan kualitas kakao adalah melalui sertifikasi pertanian berkelanjutan yaitu UTZ Certified. Salah satu pemegang sertifikat UTZ di Indonesia adalah Koperasi Kerta Semana Samaniya di Kabupaten Jembrana. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan produksi dan pendapatan usahatani kakao bersertifikat UTZ dan yang tidak mengikuti program sertifikat UTZ di Kabupaten Jembrana, mengidentifikasikan alasan petani kakao mengikuti program sertifikasi UTZ. Analisis data yang digunakan adalah menghitung pendapatan usahatani, uji beda (uji-t) dan analisis deskriptif kualitatif. Hasil penelitian menunjukkan rata-rata produktivitas usahatani kakao bersertifikat UTZ sebanyak 173,20 kg/ha dan non sertifikat sebanyak 211,88 kg/ha, yang menunjukkan bahwa produksi kakao bersertifikat UTZ lebih rendah sebesar 22,3% dibandingkan dengan non sertifikat. Pendapatan Usahatani bersertifikat UTZ lebih tinggi 45,17% yaitu sebesar Rp 4.887.639/ha/tahun dibandingkan dengan petani non sertifikat yang hanya memperoleh Rp 2.676.833/ha/tahun. Usahatani kakao bersertifikat UTZ memiliki R/C sebesar 3,3 sedangkan petani kakao non sertifikat UTZ sebesar 1,9. Hal ini menunjukkan bahwa usahatani kakao bersertifikat lebih menguntungkan dibandingkan dengan usahatani kakao non sertifikat. Tiga alasan utama petani mengikuti program sertifikasi UTZ adalah adanya sosialisasi pengenalan program sertifikasi, mendapatkan harga jual yang tinggi.Kata Kunci: Pendapatan Petani, Usahatani Kakao, UTZ Certified
Perceived relevance of tasks in organic chemistry by preservice chemistry teachers
Authors: Hermanns Jolanda 
Published: August 2020

Abstract
In this article the development, use and evaluation of tasks in organic chemistry is discussed. These tasks are designed following the concept of school-related content knowledge. In this study the perceived relevance of these new tasks by preservice chemistry teachers was evaluated. Of special interest was the question how new tasks should be designed to be perceived as relevant; are some features of the tasks more suitable than others? To answer all research questions a mixed methods study was conducted. To understand the students’ rating of the new tasks by using questionnaires, in addition focus group interviews were conducted. The suitability of these new tasks for use in written exams was also evaluated. The results show that the students perceived the tasks as relevant for their future profession if they included contents of the school curriculum, realistic situations and were personalized. They perceived the new tasks also as relevant for practicing skills in communication and explanations.
Exploring fullerenes and nanotubes in the classroom
Authors: Velentzas Athanasios , Stavrou Dimitris 
Published: August 2020

Abstract
Informing citizens about scientific issues in our highly technological world is of major importance. Toward this end, a teaching/learning sequence (TLS) focused on the nanostructures of carbon was developed and implemented in a class of secondary school students. This topic was chosen because, on the one hand, fullerenes and nanotubes are already used in a wide range of applications, and there are impressive promises for their future uses. On the other hand, from an educational point of view, students could be introduced to the important idea that some of the interesting properties at the nanoscale level are related to the structure of matter. During the development of the TLS, the fact that students would be studying extremely small-sized particles invisible to the naked eye was taken into consideration. Because of this, models and analogies were chosen as the main teaching tools to be used. In the present work, the TLS and some findings from the first implementation in the classroom are presented and discussed.