bluuebunny/crossref_metadata_2025_split huggingface dataset:
Four genetic loci control compact plant size with yellow pear‐shaped fruit in ornamental tomato (Solanum lycopersicum L.)
Authors: Safaei Meysam , Olfati Jamal‐Ali , Hamidoghli Yousef , Rabiei Babak , Yamamoto Eiji , Shirasawa Kenta 
Published: April 2020

AbstractTomato is an attractive fruiting vegetable crop that can be used as an ornamental plant. Agronomical traits have been subjected to extensive genetic dissection to enhance vegetable breeding programs. By contrast, there are few genetic studies of ornamental traits for the development of ornamental tomato varieties. To investigate genetic loci linked to desired ornamental traits, we performed genetic analyses using an intraspecific mapping population that segregated for fruit color (yellow or red), fruit shape (round or pear), and plant height (high or compact). A genetic map was constructed with 965 single nucleotide polymorphisms (SNPs) and 33 simple sequence repeat markers. Subsequent linkage analysis using quantitative locus analysis and genome‐wide association study detected four genetic loci for the three selected traits, all of which were located near the reported genes. We performed KASP—kompetitive allele‐specific PCR—to develop SNP markers that were tightly linked to the four loci. Highly accurate genotyping data were obtained from the four SNPs across 187 F2 plants, which enabled us to select two lines with homozygous alleles for compact plant size and yellow pear‐shaped fruits. These newly developed SNP markers and genetic strategies could be used to accelerate breeding programs for ornamental tomato plants.
Finitary shadows of compact subgroups of $$S(\omega )$$
Authors: Majcher-Iwanow B. 
Published: April 2020

AbstractLet LF be the lattice of all subgroups of the group $$SF(\omega )$$SF(ω) of all finitary permutations of the set of natural numbers. We consider subgroups of $$SF(\omega )$$SF(ω) of the form $$C\cap SF(\omega )$$C∩SF(ω), where C is a compact subgroup of the group of all permutations. In particular, we study their distribution among elements of LF. We measure this using natural relations of orthogonality and almost containedness. We also study complexity of the corresponding families of compact subgroups of $$S(\omega )$$S(ω).
A note on the periodic $$L_2$$-discrepancy of Korobov’s p-sets
Authors: Dick Josef , Hinrichs Aicke , Pillichshammer Friedrich 
Published: April 2020

AbstractWe study the periodic $$L_2$$L2-discrepancy of point sets in the d-dimensional torus. This discrepancy is intimately connected with the root-mean-square $$L_2$$L2-discrepancy of shifted point sets, with the notion of diaphony, and with the worst-case error of cubature formulas for the integration of periodic functions in Sobolev spaces of mixed smoothness. In discrepancy theory, many results are based on averaging arguments. In order to make such results relevant for applications, one requires explicit constructions of point sets with “average” discrepancy. In our main result, we study Korobov’s p-sets and show that this point sets have periodic $$L_2$$L2-discrepancy of average order. This result is related to an open question of Novak and Woźniakowski.
The antimycotic effect of ellagitannins from raspberry (Rubus idaeus L.) on Alternaria alternata ŁOCK 0409
Authors: Klewicka Elżbieta , Sójka Michał , Ścieszka Sylwia , Klewicki Robert , Milczarek Agnieszka , Lipińska Lidia , Kołodziejczyk Krzysztof 
Published: April 2020

AbstractAlternaria spp. fungi, characterized by a high tolerance to unfavorable environmental conditions, are one of the threats for foods of plant origin. The increasing incidence of diseases caused by a demanding lifestyle, and a higher social awareness of the role of a diet in maintaining health and good condition, results in the dynamically growing demand for natural protective measures that would be safe for consumers. Ellagitannins, i.e. a group of bio-active polyphenols, may constitute an alternative for chemical preservatives. Studies demonstrated that the raspberry (Rubus idaeus L.) ellagitannin formula limited the growth of Alternaria alternata 0409. The minimal inhibitory concentration (MIC) was determined (0.156 mg/ml), along with the minimal fungicidal concentration (MFC) (0.312 mg/ml). The fungistatic (FA) activity and the ratio of linear growth (T) were also determined for the ellagitannin formula. A strong antimycotic activity of ellagitannins was demonstrated at the formula level of 0.1 mg/ml. Unfortunately, the activity was not maintained over time and after 9 days it was only 16.0%. For the ellagitannin formula, concentrations of 0.312 mg/ml (MFC) and 0.5 mg/ml (below the MFC value), a complete arrest of growth of Alternaria alternata 0409 was observed, and it was maintained for 9 days. The antimycotic activity of the ellagitannin formula was also confirmed in food environment, with cottage cheese and cherry tomatoes used as the matrix. Results confirmed that ellagitannins from raspberry (Rubus idaeus L.) could be successfully used as a natural food preservative.
Differential neural processing of unpleasant sensory stimulation in patients with major depression
Authors: Malejko Kathrin , Brown Rebecca C. , Plener Paul L. , Bonenberger Martina , Graf Heiko , Abler Birgit 
Published: April 2020

AbstractAn altered processing of negative salient stimuli has been suggested to play a central role in the pathophysiology of major depression (MD). Besides negative affective and social stimuli, physical pain as a subtype of negative sensory stimulation has been investigated in this context. However, the few neuroimaging studies on unpleasant sensory stimulation or pain processing in MD report heterogeneous findings. Here, we investigated 47 young females, 22 with MD and 25 healthy controls (HC) using fMRI (3.0 T). Four levels of increasingly unpleasant electrical stimulation were applied. Ratings of stimulus intensity were assessed by a visual analogue scale. fMRI-data were analyzed using a 2 × 4 ANOVA. Behavioral results revealed no group differences regarding accuracy of unpleasant stimulation level ratings and sensitivity to stimulation. Regarding neural activation related to increasing levels of unpleasant stimulation, we observed increasing activation of brain regions related to the pain and salient stimulus processing corresponding to increasingly unpleasant stimulation in controls. This modulation was significantly smaller in MD compared to controls, particularly in the dorsal anterior cingulate cortex, the somatosensory cortex, and the posterior insula. Overall, brain regions associated with the processing of unpleasant sensory stimulation, but also associated with the salience network, were highly reactive but less modulated in female patients with MD. These results support and extent findings on altered processing of salience and of negative sensory stimuli even of a non-painful quality in female patients with MD.
Olaparib and temozolomide in desmoplastic small round cell tumors: a promising combination in vitro and in vivo
Authors: van Erp Anke E. M. , van Houdt Laurens , Hillebrandt-Roeffen Melissa H. S. , van Bree Niek F. H. N. , Flucke Uta E. , Mentzel Thomas , Shipley Janet , Desar Ingrid M. E. , Fleuren Emmy D. G. , Versleijen-Jonkers Yvonne M. H. , van der Graaf Winette T. A. 
Published: April 2020

Abstract
Purpose
Desmoplastic small round cell tumors (DSRCTs) are highly malignant and very rare soft tissue sarcomas with a high unmet need for new therapeutic options. Therefore, we examined poly(ADP-ribose) polymerase 1 (PARP1) and Schlafen-11 (SLFN11) expression in DSRCT tumor tissue and the combination of PARP inhibitor olaparib with the alkylating agent temozolomide (TMZ) in a preclinical DSRCT model.

Methods
PARP1 and SLFN11 have been described as predictive biomarkers for response to PARP inhibition. Expression of PARP1 and SLFN11 was assessed in 16 and 12 DSRCT tumor tissue samples, respectively. Effects of single-agent olaparib, and olaparib and TMZ combination treatment were examined using the preclinical JN-DSRCT-1 model. In vitro, single-agent and combination treatment effects on cell viability, the cell cycle, DNA damage and apoptosis were examined. Olaparib and TMZ combination treatment was also assessed in vivo.

Results
PARP1 and SLFN11 expression was observed in 100% and 92% of DSRCT tumor tissues, respectively. Olaparib treatment reduced cell viability and cell migration in a dose-dependent manner in vitro. Drug synergy between olaparib and TMZ was observed in vitro and in vivo. Combination treatment led to a cell-cycle arrest and induction of DNA damage and apoptosis, even when combined at low dosages.

Conclusion
We show high PARP1 and SLFN11 expression in DSRCT tumor material and antitumor effects following olaparib and TMZ combination treatment in a preclinical DSRCT model. This suggests that olaparib and TMZ combination treatment could be a potential treatment option for DSRCTs.
Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger’s Versus Healthy Controls: A Cross-Sectional Analysis
Authors: Del Valle Rubido Marta , Hollander Eric , McCracken James T. , Shic Frederick , Noeldeke Jana , Boak Lauren , Khwaja Omar , Sadikhov Shamil , Fontoura Paulo , Umbricht Daniel 
Published: April 2020

AbstractBiomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p = 0.0001–0.037) and pupillometry (various tasks, p = 0.017–0.05). Impaired olfaction was more common in the ASD sample versus HC (p = 0.018). Our preliminary results suggest the potential use for stratification and response sub-analyses outcome-prediction of specific eye-tracking tasks, pupillometry and olfaction tests in ASD trials
Strategic CSR in Asymmetric Cournot Duopoly
Authors: Planer-Friedrich Lisa , Sahm Marco 
Published: April 2020

AbstractWe examine the strategic use of corporate social responsibility (CSR) in Cournot competition between two firms that differ in their marginal costs of production. The level of CSR determines the weight a firm puts on consumer surplus in its objective function before it decides upon supply. We show that the more efficient firm chooses a higher CSR level, reinforcing its dominant position. If there are sufficiently large fixed costs of CSR, only the more efficient firm will engage in CSR.
Estimation of energy flow and environmental impacts of quinoa cultivation through life cycle assessment methodology
Authors: Lotfalian Dehkordi Amin , Forootan Marziye 
Published: April 2020

AbstractQuinoa is an adaptable plant that is rich in terms of nutritional properties. Currently, the promotion and cultivation of quinoa are expanding in Iran. The present study aimed to investigate the energy consumption of quinoa grain production and its environmental impacts through life cycle assessment. In this regard, in order to evaluate the environmental and energy indices, required data were collected from quinoa farmers in Isfahan. The high energy ratio (ER > 1) and positive net energy show that quinoa cultivation is efficient. Based on the results, irrigation water and nitrate fertilizer were identified as the major contributors to energy consumption. Based on the normalization method, the highest and lowest environmental impacts during the production process were related to the indices of marine aquatic ecotoxicity and ozone layer depletion, respectively. Results showed that in the global warming potential impact, 354 kg CO2eq. were emitted per production of 1 tonne of quinoa grain. Diesel fuel and nitrogen fertilizer had a significant effect on most environmental impacts. Proper management of chemical fertilizers and agricultural machinery are key factors for sustainable cultivation of quinoa.
The implications of non-anatomical positioning of a meniscus prosthesis on predicted human knee joint biomechanics
Authors: Naghibi Hamid , Janssen Dennis , van den Boogaard Ton , van Tienen Tony , Verdonschot Nico 
Published: April 2020

AbstractDespite all the efforts to optimize the meniscus prosthesis system (geometry, material, and fixation type), the success of the prosthesis in clinical practice will depend on surgical factors such as intra-operative positioning of the prosthesis. In this study, the aim was therefore to assess the implications of positional changes of the medial meniscus prosthesis for knee biomechanics. A detailed validated finite element (FE) model of human intact and meniscal implanted knees was developed based on a series of in vitro experiments. Different non-anatomical prosthesis positions were applied in the FE model, and the biomechanical response during the gait stance phase compared with an anatomically positioned prosthesis, as well as meniscectomized and also the intact knee model. The results showed that an anatomical positioning of the medial meniscus prosthesis could better recover the intact knee biomechanics, while a non-anatomical positioning of the prosthesis to a limited extent alters the knee kinematics and articular contact pressure and increases the implantation failure risk. The outcomes indicate that a medial or anterior positioning of the meniscus prosthesis may be more forgiving than a posteriorly or laterally positioned prosthesis. The outcome of this study may provide a better insight into the possible consequences of meniscus prosthesis positioning errors for the patient and the prosthesis functionality.
A novel palpation–based method for tumor nodule quantification in soft tissue—computational framework and experimental validation
Authors: Palacio-Torralba Javier , Reuben Robert L. , Chen Yuhang 
Published: April 2020

AbstractVariation in mechanical properties is a useful marker for cancer in soft tissue and has been used in clinical diagnosis for centuries. However, to develop such methods as instrumented palpation, there remain challenges in using the mechanical response during palpation to quantify tumor load. This study proposes a computational framework of identification and quantification of cancerous nodules in soft tissue without a priori knowledge of its geometry, size, and depth. The methodology, using prostate tissue as an exemplar, is based on instrumented palpation performed at positions with various indentation depths over the surface of the relevant structure (in this case, the prostate gland). The profile of force feedback results is then compared with the benchmark in silico models to estimate the size and depth of the cancerous nodule. The methodology is first demonstrated using computational models and then validated using tissue-mimicking gelatin phantoms, where the depth and volume of the tumor nodule is estimated with good accuracy. The proposed framework is capable of quantifying a tumor nodule in soft tissue without a priori information about its geometry, thus presenting great promise in clinical palpation diagnosis for a wide variety of solid tumors including breast and prostate cancer.
Changes in the network of tourist trails in the border zones of the Czech Republic after entering the Schengen area
Authors: Kołodziejczyk Krzysztof 
Published: April 2020

AbstractAmong the factors influencing tourist trail network development are political issues, including the presence of state borders, the possibility of crossing them and the accessibility of border zones. In the article, it was decided to look at changes in the offer of tourist trails (hiking and cycling) along the entire border of the Czech Republic after the extension of the Schengen area (within this area, crossing the border is possible anywhere, and not only at official border crossings). It should be emphasized here that the borders of the Czech Republic over most of their length run through mountainous areas and, apart from political factors, natural features should have a major impact on the development of tourist routes. In order to determine the coherence of the current network of trails on both sides of the Czech Republic state border, modern tourist maps have been analyzed, determining the number of places where it is possible to cross the state border with the help of a marked tourist trail. Based on that, two indicators were introduced to determine the degree of openness with all neighboring countries as regards the opportunity to cross on a tourist trail. Changes in the historical situation, a comparison of the accessibility of the border area before entering the Schengen area and 2019, were analyzed for two study areas using archival maps. Over a decade after the extension of the Schengen area, the number of places where tourist trails of neighboring countries approach the border has clearly increased. Crossing is more often made possible using hiking trails than cycling routes (trails of the first type cross the border every 7.91 km, while the latter every 13.3 km), but considering the speed of movement, it can be assessed that the openness for cyclists is higher than for hikers. Moreover, in many places there is still significant potential for further integration of tourist trail networks as trails created in one country often do not have a continuation on the other side of the border.
The Procedureless Elipse Gastric Balloon Program: Multicenter
Experience in 1770 Consecutive Patients
Authors: Ienca R. , Al Jarallah Mohammed , Caballero Adelardo , Giardiello Cristiano , Rosa Michele , Kolmer Sébastien , Sebbag Hugues , Hansoulle Julie , Quartararo Giovanni , Zouaghi Sophie Al Samman , Juneja Girish , Murcia Sébastien , Turro Roman , Pagan Alberto , Badiuddin Faruq , Dargent Jérôme , Urbain Pierre , Paveliu Stefan , di Cola Rita Schiano , Selvaggio Corrado , Al Kuwari Mohammed 
Published: April 2020

Abstract
Purpose
The Elipse balloon is a novel, non-endoscopic option for weight
loss. It is swallowed and filled with fluid. After 4 months, the balloon
self-empties and is excreted naturally. Aim of the study was to evaluate safety
and efficacy of Elipse balloon in a large, multicenter, population.

Materials and Methods
Data from 1770 consecutive Elipse balloon patients was analyzed.
Data included weight loss, metabolic parameters, ease of placement, device
performance, and complications.

Results
Baseline patient characteristics were mean age
38.8 ± 12, mean weight
94.6 ± 18.9 kg, and mean BMI
34.4 ± 5.3 kg/m2.
Triglycerides were 145.1 ± 62.8 mg/dL, LDL
cholesterol was 133.1 ± 48.1 mg/dL, and HbA1c was
5.1 ± 1.1%. Four-month results were WL
13.5 ± 5.8 kg, %EWL
67.0 ± 64.1, BMI reduction 4.9 ± 2.0,
and %TBWL 14.2 ± 5.0. All metabolic parameters improved.
99.9% of patients were able to swallow the device with 35.9% requiring stylet
assistance. Eleven (0.6%) empty balloons were vomited after residence. Fifty-two
(2.9%) patients had intolerance requiring balloon removal. Eleven (0.6%)
balloons deflated early. There were three small bowel obstructions requiring
laparoscopic surgery. All three occurred in 2016 from an earlier design of the
balloon. Four (0.02%) spontaneous hyperinflations occurred. There was one
(0.06%) case each of esophagitis, pancreatitis, gastric dilation, gastric outlet
obstruction, delayed intestinal balloon transit, and gastric perforation
(repaired laparoscopically).

Conclusion
The Elipse™ Balloon demonstrated an excellent safety profile.
The balloon also exhibited remarkable efficacy with 14.2% TBWL and improvement
across all metabolic parameters.
Long-term cervical cancer survivors on disability pension: a subgroup in need of attention from health care providers
Authors: Dahl Alv A. , Bentzen Anne Gry , Fosså Sophie D. , Hess Siri Lothe , Steen Rita , Kiserud Cecilie E. 
Published: April 2020

Abstract
Purpose
Survivors of cervical cancer have an increased risk for permanently reduced work ability qualifying for disability pension (DP). Few studies describe the social and health situation of long-term survivors of cervical cancer (LSCCs) on DP as a subgroup among LSCCs. The purpose was to investigate the socio-demographic and health status of LSCCs holding DP in a population-based cohort using LSCCs holding paid work as reference.

Methods
Altogether, 354 LSCCs under 67 years (age of retirement pension in Norway) at survey participated in this study. They responded to a mailed questionnaire containing social, health, and clinical issues.

Results
Among LSCCs 24% held DP at a median of 11 years (range 6–15) after diagnosis versus 12% in the general female population. Compared to LSCCs in paid work, those on DP had significantly higher mean age at survey, short education, more comorbid somatic diseases, poorer self-rated health, higher level of neurotoxic side effects, more chronic fatigue, and higher mean levels of anxiety and depression. Increased age, presence of musculo-skeletal diseases, and increased levels of depression and pain remained significantly associated with DP in multivariate analysis.

Conclusions
One in four LSCCs held DP which was twice the rate of the general female population. Several somatic and psychological conditions amenable to treatment were significantly associated with holding DP.

Implications for Cancer Survivors
LSCCs holding DP should check their health regularly since conditions that can be treated are common, and health care providers should be aware of this opportunity.
Simulation-based assessment of data center waste heat utilization using aquifer thermal energy storage of a university campus
Authors: Dvorak Vojtech , Zavrel Vojtech , Torrens Galdiz J. I. , Hensen Jan L. M. 
Published: April 2020

AbstractThe global energy consumption of data centers (DCs) has experienced exponential growth over the last decade, that is expected to continue in the near future. Reasonable utilization of DC waste heat, which is dissipated during the computational process, can potentially be an effective solution to mitigate the environmental impact. However, the practical implementation of waste heat utilization in the DC environment is a very challenging task. The possible benefits of waste heat utilization are uncertain and difficult to quantify with the methods that are common in practice. This paper introduces a feasibility study in which dynamic simulation tools were used to predict the energy performance of a university campus resulting from the integration of a proposed DC system with an existing aquifer thermal energy storage (ATES). The presented study utilizes building energy simulation (BES) to evaluate uncertainty of the waste heat potential associated to various thermal management strategies of the proposed DC. Further in the feasibility study, the carbon footprint of the integrated approach is assessed for both the current and future situation based on measured data from the existing university campus and its district ATES system.