bluuebunny/crossref_metadata_2025_split huggingface dataset:
Care challenges in older general hospital patients
Authors: Hendlmeier Ingrid , Bickel Horst , Heßler-Kaufmann Johannes Baltasar , Schäufele Martina 
Published: October 2019

Abstract

Background
Older general hospital patients, particularly those with cognitive impairment, frequently experience adverse events and other care complications during their stay. As these findings have so far been based on small and selected patient samples, the aim of the present study was to provide reliable data on a) the prevalence of adverse care issues (summarized under the term care challenges) in older general hospital patients and on b) associated patient-related risk factors (e.g. cognitive impairment).

Methods
A cross-sectional representative study comprising 1469 patients aged ≥65 years from 33 randomly selected general hospitals in southern Germany (GHoSt). Data collection included the use of different data sources, e.g. structured interviews with responsible nursing staff concerning care challenges and procedures for determining the patients’ cognitive status.

Results
Care challenges were statistically significantly (p < 0.001) more often reported for patients with dementia and/or delirium (87.5%) and mild cognitive impairment (47.9%) compared to cognitively unimpaired patients (24.6%). Adjusted odds ratios suggested cognitive impairment, impaired activities of daily living, receiving long-term care and unplanned admission as significant patient-related risk factors for care challenges. Furthermore, the occurrence of such issues was associated with the application of physical restraints, support from relatives, prescription of psycholeptics and specialist consultations.

Conclusion
The findings suggest a strong impact of different degrees of cognitive impairment on challenges in care. The results might help to design appropriate training programs for hospital staff and other interventions to prevent or reduce critical situations.
Optimal dividends with partial information and stopping of a degenerate reflecting diffusion
Authors: De Angelis Tiziano 
Published: October 2019

Abstract
We study the optimal dividend problem for a firm’s manager who has partial information on the profitability of the firm. The problem is formulated as one of singular stochastic control with partial information on the drift of the underlying process and with absorption. In the Markovian formulation, we have a two-dimensional degenerate diffusion whose first component is singularly controlled. Moreover, the process is absorbed when its first component hits zero. The free boundary problem (FBP) associated to the value function of the control problem is challenging from the analytical point of view due to the interplay of degeneracy and absorption. We find a probabilistic way to show that the value function of the dividend problem is a smooth solution of the FBP and to construct an optimal dividend strategy. Our approach establishes a new link between multidimensional singular stochastic control problems with absorption and problems of optimal stopping with ‘creation’. One key feature of the stopping problem is that creation occurs at a state-dependent rate of the ‘local time’ of an auxiliary two-dimensional reflecting diffusion.
Assessment of microplastic pollution: occurrence and characterisation in Vesijärvi lake and Pikku Vesijärvi pond, Finland
Authors: Scopetani Costanza , Chelazzi David , Cincinelli Alessandra , Esterhuizen-Londt Maranda 
Published: October 2019

Abstract
In the last few years, several studies have investigated microplastics (MPs) in marine ecosystems, but data monitoring and assessing the occurrence in freshwater environments are still scarce. The present study aims to investigate the occurrence, distribution, and chemical composition of MP pollution in Vesijärvi lake and Pikku Vesijärvi pond close to the city of Lahti (Finland) in winter. Sediment, snow, and ice core samples were collected near the shore of these two aquatic systems. MPs were analysed and identified by a non-destructive method using Fourier transform infrared spectroscopy (FTIR) 2D imaging. The mean concentrations of MPs detected in sediment, snow, and ice samples were 395.5 ± 90.7 MPs/kg, 117.1 ± 18.4 MPs/L, and 7.8 ± 1.2 MPs/L, respectively. FTIR results showed the predominant abundance of microplastics, such as polyamides (up to 53.3%), polyethylene and polypropylene (up to 17.1%), and natural fragments such as cellulose (up to 45.8%) and wool (up 18.8%) in the same size range. The potential release of MPs arising from stormwaters and sport and recreational activities was evidenced.
International Evidence on the Determinants of Domestic Sovereign Debt Bank Holdings
Authors: Chronopoulos Dimitris K. , Dotsis George , Milonas Nikolaos T. 
Published: October 2019

Abstract
In this paper, we examine the determinants of bank holdings of domestic sovereign debt with a panel dataset of 295 banks in 35 countries between 2002 and 2013. The findings indicate that the structure of bank ownership (domestic, foreign, or government ownership), the quality of governance, and the level of financial development of the countries in which banks operate all determine the level of home bias. Specifically, we find that domestic banks tend to hold more domestic sovereign debt relative to their foreign counterparts. We also provide evidence that home bias is even stronger when the domestic bank is controlled by its government. Moreover, home bias increases when government bonds are more risky, home governments are less effective, and when banking systems are less financially developed. Overall, we find that banks’ home bias in holding sovereign debt is an international phenomenon that is determined by both bank- and country-specific factors.
Gravitational Energy in Newtonian Gravity: A Response to Dewar and Weatherall
Authors: Duerr Patrick M. , Read James 
Published: October 2019

Abstract
The paper investigates the status of gravitational energy in Newtonian Gravity (NG), developing upon recent work by Dewar and Weatherall. The latter suggest that gravitational energy is a gauge quantity. This is potentially misleading: its gauge status crucially depends on the spacetime setting one adopts. In line with Møller-Nielsen’s plea for a motivational approach to symmetries, we supplement Dewar and Weatherall’s work by discussing gravitational energy–stress in Newtonian spacetime, Galilean spacetime, Maxwell-Huygens spacetime, and Newton–Cartan Theory (NCT). Although we ultimately concur with Dewar and Weatherall that the notion of gravitational energy is problematic in NCT, our analysis goes beyond their work. The absence of an explicit definition of gravitational energy–stress in NCT somewhat detracts from the force of Dewar and Weatherall’s argument. We fill this gap by examining the supposed gauge status of prima facie plausible candidates—NCT analogues of gravitational energy–stress pseudotensors, the Komar mass, and the Bel-Robinson tensor. Our paper further strengthens Dewar and Weatherall’s results. In addition, it sheds more light upon the subtle link between sufficiently rich inertial structure and the definability of gravitational energy in NG.
Responsible Innovation for Life: Five Challenges Agriculture Offers for Responsible Innovation in Agriculture and Food, and the Necessity of an Ethics of Innovation
Authors: Gremmen Bart , Blok Vincent , Bovenkerk Bernice 
Published: October 2019

Abstract
In this special issue we will investigate, from the perspective of agricultural ethics (e.g. animal welfare, agricultural and food ethics, environmental ethics etc.) the potential to develop a Responsible Research and Innovation (RRI) approach to agriculture, and the limitations to such an enterprise. RRI is an emerging field in the European research and innovation (R&I) policy context that aims to balance economic, socio-cultural and environmental aspects in innovation processes. Because technological innovations can contribute significantly to the solution of societal challenges like climate change or food security, but can also have negative societal consequences, it is assumed that social and ethical aspects should be considered during the R&I process. For this reason, the emerging concept of RRI calls for ethical reflection on the nature, scope and applicability of responsibility and innovation in innovation practices in general, and the way social–ethical issues can be applied and addressed in agriculture.
Network-based piecewise linear regression for QSAR modelling
Authors: Cardoso-Silva Jonathan , Papageorgiou Lazaros G. , Tsoka Sophia 
Published: October 2019

Abstract
Quantitative Structure-Activity Relationship (QSAR) models are critical in various areas of drug discovery, for example in lead optimisation and virtual screening. Recently, the need for models that are not only predictive but also interpretable has been highlighted. In this paper, a new methodology is proposed to build interpretable QSAR models by combining elements of network analysis and piecewise linear regression. The algorithm presented, modSAR, splits data using a two-step procedure. First, compounds associated with a common target are represented as a network in terms of their structural similarity, revealing modules of similar chemical properties. Second, each module is subdivided into subsets (regions), each of which is modelled by an independent linear equation. Comparative analysis of QSAR models across five data sets of protein inhibitors obtained from ChEMBL is reported and it is shown that modSAR offers similar predictive accuracy to popular algorithms, such as Random Forest and Support Vector Machine. Moreover, we show that models built by modSAR are interpretatable, capable of evaluating the applicability domain of the compounds and serve well tasks such as virtual screening and the development of new drug leads.
Nano-mechanical Properties and Pore-Scale Characterization of Different Rank Coals
Authors: Zhang Yihuai , Lebedev Maxim , Smith Gregory , Jing Yu , Busch Andreas , Iglauer Stefan 
Published: October 2019

ABSTRACT
Characterization of coal micro-structure and the associated rock mechanical properties are of key importance for coal seam exploration, coal bed methane development, enhanced coal bed methane production and CO2 storage in deep coal seams. Considerable knowledge exists about coal chemical properties, but less is known about the nanoscale to the micro-scale structure of coals and how they change with coal strength across coal ranks. Thus, in this study, 3D X-ray micro-computed tomography (with a voxel size of 3.43 µm) and nano-indentation tests were conducted on coal samples of different ranks from peat to anthracite. The micro-structure of peats showed a well-developed pore system with meso- and micro-pores. The meso-pores essentially disappear with increasing rank, whereas the micro-pores persist and then increase past the bituminous rank. The micro-fracture system develops past the peat stage and by sub-bituminous ranks and changes into larger and mature fracture systems at higher ranks. The nano-indentation modulus showed the increasing trend from low- to high-rank coal with a perfect linear relationship with vitrinite reflectance and is highly correlated with carbon content as expected.
TrendNets: mapping emerging research trends from dynamic co-word networks via sparse representation
Authors: Katsurai Marie , Ono Shunsuke 
Published: October 2019

Abstract
Mapping the knowledge structure from word co-occurrences in a collection of academic papers has been widely used to provide insight into the topic evolution in an arbitrary research field. In a traditional approach, the paper collection is first divided into temporal subsets, and then a co-word network is independently depicted in a 2D map to characterize each period’s trend. To effectively map emerging research trends from such a time-series of co-word networks, this paper presents TrendNets, a novel visualization methodology that highlights the rapid changes in edge weights over time. Specifically, we formulated a new convex optimization framework that decomposes the matrix constructed from dynamic co-word networks into a smooth part and a sparse part: the former represents stationary research topics, while the latter corresponds to bursty research topics. Simulation results on synthetic data demonstrated that our matrix decomposition approach achieved the best burst detection performance over four baseline methods. In experiments conducted using papers published in the past 16 years at three conferences in different fields, we showed the effectiveness of TrendNets compared to the traditional co-word representation. We have made our codes available on the Web to encourage scientific mapping in all research fields.
Return to Sport after Coracoid Bone Block Transfer for Shoulder Instability: A Systematic Review
Authors: Nadeem Ibrahim M. , Vancolen Seline , Horner Nolan S. , Bedi Asheesh , Alolabi Bashar , Khan Moin 
Published: October 2019

Background Shoulder dislocations can be devastating for an athlete. Coracoid bone block transfer is often used for the treatment of recurrent shoulder instability. Questions/Purposes The primary purpose of this study was to determine the rate and mean time of return to sport in athletes after a coracoid bone block transfer at the pre-operative level of competition, a lower level, or a different level. We also sought to determine how return to sport rates after a coracoid bone block procedure compared with rates after several comparator interventions. Finally, we looked to determine the post-operative clinical outcomes and complications reported after a coracoid bone block procedure. Methods We systematically searched three databases (PubMed, Embase, and MEDLINE) for studies reporting return to sport after a coracoid bone block procedure. Results A total of 52 studies (with levels of evidence ranging from II to IV) evaluating 2953 shoulders in 2888 patients were included in this systematic review. The mean rate of return to sport at any level was 88.4% (2291 of 2592 patients). However, the rate of return to the pre-operative level was 70.3% (1387 of 1974 patients). The mean time to return to sport was 5.38 months (range 21 days to 36 months). The rate of return to sport was higher after the Latarjet procedure, as compared with Bankart repair (87.0% and 75.8%, respectively). All studies showed improvements in clinical outcome measures after coracoid bone block intervention. The cumulative complication rate was found to be 6.46% (158 of 2446 patients). Conclusion Coracoid bone block transfer allows for a high rate of return to sport, although the rate of return to sport at athletes’ pre-operative level is lower. The rate of return to sport after Latarjet procedure is higher in comparison with Bankart repair. Additionally, coracoid bone block transfer is associated with improvements in a number of clinical outcome measures. Common post-operative complications include non-union between bone block and glenoid, hematoma, and infection.
Effects of soil nutrient availability and ozone on container-grown Japanese larch seedlings and role of soil microbes
Authors: Agathokleous Evgenios , Kitao Mitsutoshi , Komatsu Masabumi , Tamai Yutaka , Saito Hideyuki , Harayama Hisanori , Uemura Akira , Tobita Hiroyuki , Koike Takayoshi 
Published: October 2019

AbstractThe interactive effects of ozone, soil nutrient availability and root microorganisms on physiological, growth, and productivity traits were studied for the first time for Japanese larch (Larix kaempferi) seedlings grown in containers over a growing season, using a free air ozone-concentration enrichment exposure system. High nutrient availability altered leaf and root nutrient dynamics and enhanced plant growth; however, it also enhanced seedling susceptibility to damping-off disease compared to low nutrient availability. Negative effects of elevated ozone, as compared with ambient ozone, on leaf gas exchange and plant stem form were neither offset nor exacerbated by soil nutrient availability and root colonizers. Such negative effects suggest that elevated ozone may have implications for ecological health even when plant vigor is limited by factors other than ozone. Inoculation of roots with ectomycorrhizae had negligible influence on the effects of either soil nutrient availability or ozone. However, this lack of effect may be upon impeded formation of complete mycorrhizal root tips due to factors other than the manipulated variables. B and Na appeared to have an important role in stress responses, so further studies to examine their link with physiological mechanisms as a function of time. This study provides an important perspective for designing forestry practices to enhance seedling health.
Immunohistochemical Characterization of Reactive Epithelial Changes in Odontogenic Keratocysts
Authors: Cserni Dorottya , Zombori Tamás , Stájer Anette , Rimovszki Annamária , Cserni Gábor , Baráth Zoltán 
Published: October 2019

Abstract
Odontogenic keratocysts (OKCs) have a diagnostic thin epithelial lining characterised by a linear epithelial connective tissue interface generally lacking inflammatory changes, basal palisading of the nuclei and a wavy parakeratotic layer on the surface. This typical epithelium may convert to a thicker non-keratinizing one with rete pegs and a relatively flat surface after operative decompression. The aim was to characterize this type of epithelial change by immunohistochemistry for bcl2, keratin17, 10 and 19. Eleven out of 33 archived OKCs demonstrated an altered epithelium related to previous biopsy, decompressing drainage or inflammation. The typical basal bcl2 staining was lost in 10/11 cases; transepithelial CK17 was lost or markedly reduced in 9/11 cases. CK10 displayed a segmental upper layer staining in OKCs, and its loss or partial loss in the altered epithelium did not differ from negative areas of OKCs. CK19 displayed various staining patterns in the altered epithelium from lost to maintained in a patchy transepithelial distribution, the latter of which did not differ from the typical OKC staining pattern. Three of four non-keratinizing epithelial linings with basal palisading displayed immunostaining reminiscent of typical OKC epithelium. The lack of a typical epithelium is not sufficient to exclude the diagnosis of OKC if the sampling is not generous (e.g. biopsy), and the presence of non-keratinizing epithelium with basal palisading and an immunophenotype characteristic of OKC (basal bcl2, patchy or diffuse CK17 and upper layer CK10 positivity) may be consistent with the OKC diagnosis even in the absence of typical epithelial lining.
Generation of mode 2 internal waves by the interaction of mode 1 waves with topography
Authors: Liu Zihua , Grimshaw Roger , Johnson Edward 
Published: October 2019

Oceanic internal waves can be decomposed into an infinite set of modes, and the dominant internal mode 1 waves have been extensively investigated. Although mode 2 waves have been observed, they have not received comparable attention, especially the generation mechanisms. In this work, we examine the generation of mode 2 internal waves by the interaction of mode 1 waves with topography. We use a coupled linear long-wave theory with mode coupling through topography, combined with evolution using a Korteweg–de Vries model, to predict the mode 2 wave amplitude, in an ideal three-layer fluid model, in a smooth density stratification and in two realistic oceanic settings. We find that the mode 2 wave amplitude is usually much smaller than the incident mode 1 wave amplitude and is quite sensitive to the pycnocline thickness, topographic slope and background stratification.
Mean dynamics and transition to turbulence in oscillatory channel flow
Authors: Ebadi Alireza , White Christopher M. , Pond Ian , Dubief Yves 
Published: October 2019

The mean dynamics in oscillatory channel flow is examined to investigate the dynamical mechanisms underlying the transition to turbulence in oscillatory wall-bounded flow. The analyses employ direct numerical simulation data acquired at three Stokes Reynolds numbers: $Re_{s}=648$, 801 and 1009, where the lower $Re_{s}$ flow is transitional over the entire cycle and the two higher $Re_{s}$ flows exhibit flow characteristics similar to steady turbulent wall-bounded flow during part of the cycle. The flow evolution over a half-period of oscillation for all three $Re_{s}$ is as follows: near-wall streamwise velocity streaks develop during the early accelerating portion of the cycle; then at some later point in the cycle that depends on $Re_{s}$, the near-wall streaks breakdown (demarking the onset of the nonlinear development stage), and the near-wall Reynolds stress grows explosively; the Reynolds stress remains elevated for part of the cycle before diminishing (yet remaining finite) during the late decelerating portion of the cycle. This process is then repeated indefinitely. The present findings demonstrate that transition to turbulence occurs when the nonlinear development stage begins during the accelerating portion of the cycle. This crucially leads to the diminishing importance of the centreline momentum source, the emergence of a locally accelerating/decelerating internal layer centred about the edge of the Stokes layer and the wall-normal rearrangement of the mean forces prior to the start of the decelerating portion of the cycle. The rearrangement of mean forces culminates in a four layer structure in the mean balance of forces. This is significant on a number of accounts since empirical and theoretical evidence suggests that the formation of a four layer structure is an important characteristic of a self-similar hierarchal structure that underlies logarithmic dependence of the mean velocity profile in steady turbulent wall-bounded flows (Klewicki et al., J. Fluid Mech., vol. 638, 2009, pp. 73–93). When the nonlinear development stage begins during the decelerating portion of the cycle (i.e. at $Re_{s}=648$), a four layer structure is not observed in the mean balance of forces and the flow remains weakly transitional over the entire cycle.
Experimental investigation of the wave-induced motion of and force distribution along a flexible stem
Authors: Jacobsen Niels G. , Bakker Wout , Uijttewaal Wim S. J. , Uittenbogaard Rob 
Published: October 2019

The work presents an experimental investigation into the motion of and hydrodynamic forces along a single flexible stem in regular waves. The experiment covers a large range in relevant non-dimensional parameters: the drag-to-stiffness ratio $CaL\in [0.003,3.8]$, the inertia-to-stiffness ratio $CaL/KC\in [4\times 10^{-5},14.8]$, the Keulegan–Carpenter number $KC\in [3.8,145]$ and the Reynolds number $Re\in [230,2900]$. The two first parameters relate to the response of the stem in waves and thus account for material properties, while the two last parameters are relevant for hydrodynamic forces on the stem. The displacement of the stem was captured with a digital video camera and the displacement along the stem was captured for every 2.5 mm at 25 Hz. This unique laboratory data set allowed for the following analyses: (i) Determination of the relevant non-dimensional parameter to predict the stem motion and shape. (ii) A direct comparison between the measured force for mimics of two lengths (0.15 m and 0.30 m) illustrating the force reduction potential for flexible mimics. (iii) Direct evaluation of the average force coefficients $C_{D}$ (drag) and $C_{M}$ (inertia) for the flexible stems. (iv) The distributed external hydrodynamic loading and the internal shear forces were estimated from the laboratory experiments. The distribution of the shear force helped to understand the breakage mechanisms of flexible stems. (v) A linkage between phase lags and internal shear forces was suggested. The data set is considered valuable as validation material for numerical models of stem motion in waves.