bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical impact of cardiovascular disease on patients with bronchiectasis
Authors: Chen Shanshan , Qiu Aimin , Tao Zhang , Zhang Hailin 
Published: April 2020

Abstract
Background
Patients with bronchiectasis have a higher cardiovascular risk than their matched controls. However, the effect of cardiovascular (CV) disease on bronchiectasis remains unclear. Thus, we aimed to investigate the clinical impacts of cardiovascular disease on adult patients with bronchiectasis.

Methods
The study cohort comprised 603 consecutive inpatients diagnosed with bronchiectasis in the Affiliated Yancheng Hospital of Southeast University Medical College (Jiangsu, China) from January 2014 to December 2017. Symptoms, bacterial cultures, blood biochemical indicator levels, and chest high-resolution computed tomography scans were assessed during their initial hospitalization for bronchiectasis. Three hundred and thirty five subjects finished 1 year follow-up after their hospital discharge.

Results
Three hundred thirty five patients had at least one bronchiectasis exacerbation during the 1-year follow-up period. Patients with CV comorbidities were more likely to present with symptoms of wheezing (65.3%) and had a higher levels of brain natriuretic peptide (P < 0.001) and D-dimer (P < 0.001) than those without CV comorbidities. Independent risk factors associated with bronchiectasis exacerbations were the presence of comorbidities of cardiovascular diseases (odds ratio [OR] 2.503, 95% confidence interval [CI] 1.298–4.823; P = 0.006), the isolation of Pseudomonas aeruginosa (OR 2.076, 95% CI 1.100–3.919; P = 0.024), and extension to more than two lobes (OR 2.485, 95% CI 1.195–5.168; P = 0.015).

Conclusion
The existence of cardiovascular disease was independently associated with increased bronchiectasis exacerbation.
Determinants of traditional medicine utilization for children: a parental level study in Tole District, Oromia, Ethiopia
Authors: Hailu Fekensa , Cherie Amsale , Gebreyohannis Tigistu , Hailu Reta 
Published: April 2020

Abstract
Background
In Ethiopia, about 80% of the population use traditional medicine (TM) due to the cultural acceptability of healers and local pharmacopeias, the relatively low cost of traditional medicine, and the difficulty of accessing modern health facilities. This study was aimed at assessing traditional medicine utilization and its determinants among parents of the children employing a case study of the Tole District of South West of Oromia, Ethiopia.

Methods
A community-based cross-sectional data were collected from 267 parents who have children less than 18 years old. The respondents were selected through a systematic random sampling technique. Both descriptive and exploratory techniques were used to analyze the data. The exploratory logistic regression analysis was carried out to identify factors determining the use of traditional medicine (TM).

Results
We found out that 85.9% of parents used TM for their children. Herbal medicine 73 (34.4%), massage 55 (25.9%), and religious/prayer therapy 25 (11.8%) were the major therapies used by parents for their children. In the study area, the rate of parental TM utuilization for their children was determined by monthly income [OR: 0.25(0.08, 0.78)], cultural belief [OR: 3.01(1.16, 7.83)], religious belief [OR = 3.17(1.26, 7.93)], and duration of illness [OR = 3.11(1.07, 9.02)].

Conclusion
Traditional medicine use is highly prevalent that its contribution to the public health is significant as some could not access to and afford modern health services in the area. Therefore, health professionals should advise parents side-by-side procuring modern health services. In light of this, further research will be needed on the safety and efficacy of TM for wider application.
IL-33, diet-induced obesity, and pulmonary responses to ozone
Authors: Kasahara David I. , Shore Stephanie A. 
Published: April 2020

Abstract
Background
Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesity-related changes in the response to ozone in mice with diet-induced obesity.

Methods
Male wildtype C57BL/6 mice and mice deficient in ST2, the IL-33 receptor, were placed on chow or high fat diets for 12 weeks from weaning. Because the microbiome has been implicated in obesity-related changes in the pulmonary response to ozone, mice were either housed with other mice of the same genotype (same housed) or with mice of the opposite genotype (cohoused). Cohousing transfers the gut microbiome from one mouse to its cagemates.

Results
Diet-induced increases in body mass were not affected by ST2 deficiency or cohousing. In same housed mice, ST2 deficiency reduced ozone-induced airway hyperresponsiveness and neutrophil recruitment in chow-fed but not HFD-fed mice even though ST2 deficiency reduced bronchoalveolar lavage IL-5 in both diet groups. In chow-fed mice, cohousing abolished ST2-related reductions in ozone-induced airway hyperresponsiveness and neutrophil recruitment, but in HFD-fed mice, no effect of cohousing on these responses to ozone was observed. In chow-fed mice, ST2 deficiency and cohousing caused changes in the gut microbiome. High fat diet-feeding caused marked changes in the gut microbiome and overrode both ST2-related and cohousing-related differences in the gut microbiome observed in chow-fed mice.

Conclusion
Our data indicate a role for IL-33 in pulmonary responses to ozone in chow-fed but not high fat diet-fed mice and are consistent with the hypothesis that these diet-related differences in the role of IL-33 are the result of changes in the gut microbiome.
Bone tissue and mineral metabolism in hereditary endocrine tumors: clinical manifestations and genetic bases
Authors: Maraghelli Davide , Giusti Francesca , Marini Francesca , Brandi Maria Luisa 
Published: April 2020

AbstractInherited endocrine tumors are neoplasms of endocrine cells, transmitted via autosomal dominant germinal mutations. They present in two different forms: non-syndromic (patient has a single affected endocrine organ during his/her lifetime) or syndromic forms (multiple tumors in endocrine and non-endocrine organs during his/her lifetime).In addition to their common tumoral manifestations, many of these diseases present clinical affection of bone tissues and/or mineral metabolism, both as secondary complications of primary tumors and as primary defects due to genetic mutation. To date, few studies have documented these bone complications, and there are no systematic reviews in this area.We present a revision of medical literature about skeletal and mineral metabolism affections in inherited endocrine tumor syndromes, and studies, in cells and animal models, investigating the direct role of some genes, whose mutations are responsible for the development of endocrine tumors, in the regulation of bone and mineral metabolism.
A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma
Authors: Guo Chunmei , Gao Chao , Zhao Dongting , Li Jiahui , Wang Jinxia , Sun Xujuan , Liu Qinlong , Hao Lihong , Greenaway Frederick T. , Tian Yuxiang , Liu Shuqing , Sun Ming-Zhong 
Published: April 2020

Abstract
Background
Tumor metastasis is one of the main causes of the high mortality of hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) is a strong transcriptional repressor, associated with the development and progression of tumors. However, the exact role and underlying mechanism of ETV6 in HCC remain unclear.

Methods
Western blotting, quantitative real-time PCR and immunohistochemistry were used to detect the expression levels of ETV6, CRKL (v-crk sarcoma virus CT10 oncogene homologue (avian)-like) and miR-429 in HCC tissues and cells; Transwell chamber and F-actin cytoskeleton staining assay to examine the effects of ETV6 and CRKL deregulation on the migration, invasion and cytoskeleton of HCC cells; Co-immunoprecipitation assay to determine the interaction between CRKL and ETV6; Chromatin immunoprecipitation assay to investigate the interaction between ETV6 and miR-429.

Results
We established a novel ETV6-miR-429-CRKL regulatory circuitry contributes to HCC metastasis. ETV6 and CRKL were frequently increased, while miR-429 was downregulated in both hepatocarcinoma tissues and hepatocarcinoma cells. Moreover, ETV6 upregulation was positively correlated with CRKL upregulation, and two negative correlations were also established for ETV6 and CRKL upregulation with miR-429 downregulation in both hepatocarcinoma patients’ tumorous tissues and hepatocarcinoma cells. Functional investigations revealed that overexpression and knockdown of ETV6 was remarkably effective in promoting and suppressing HCC cell migration, invasion, cytoskeleton F-actin expression and arrangement, whereas, CRKL overexpression exhibited similar effects to the overexpression of ETV6. Mechanistically, ETV6 negatively regulates miR-429 expression by directly binding to the promoter region of miR-429; miR-429 negatively regulates CRKL expression by selectively targeting CRKL-3′-UTR; ETV6 directly binds to CRKL and positively regulates its expression, which in turn CRKL positively regulates ETV6 expression.

Conclusions
Our data demonstrated that ETV6 promotes migration and invasion of HCC cells by directly binding to promoter region of miR-429 via modulating CRKL expression. The newly identified ETV6-miR-429-CRKL regulatory circuitry contributes to the aggressiveness of HCC, which provides new clues for fundamental research on diagnosis and treatment parameters for HCC.
Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis
Authors: Bausch Kathrin , Aghlmandi Soheila , Sutter Sarah Ursula , Stamm Linda Maria , Ewald Hannah , Appenzeller-Herzog Christian , Roth Jan Adam , Widmer Andreas F. , Seifert Hans-Helge 
Published: April 2020

Abstract
Background
The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic prophylaxis and rising antimicrobial resistance rates. The objective of this systematic review and meta-analysis is to compare the impact of different antimicrobial prophylaxis schemes versus placebo on the prevention of postoperative UTI and asymptomatic bacteriuria.

Methods
We designed and registered a study protocol for a systematic review and meta-analysis of randomized controlled trials and non-randomized (e.g. cohort, case-control) studies examining any form of antibiotic prophylaxis in patients with transurethral resection of bladder tumours. Literature searches will be conducted in several electronic databases (from inception onwards), including MEDLINE (Ovid), EMBASE (Ovid), and the Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching conference abstracts. The primary outcome will be postoperative urinary tract infections. The secondary outcome will be asymptomatic bacteriuria. Two reviewers will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using appropriate tools (e.g. Risk of Bias 2.0 tool and Newcastle-Ottawa Scale). If feasible, we will conduct random-effects meta-analysis of outcome data. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g. study design, publication year, the setting of the study, and antibiotics regimen).
We will also search, identify, and discuss potential risk factors for urinary tract infections following transurethral resection of bladder tumours. This may serve as basis for a scoping review.

Discussion
In times of rising antimicrobial resistance rates, sound evidence on the necessity of antibiotic prophylaxis is essential for implementation into guideline recommendations and for decision-making in clinical practice.

Systematic review registration
PROSPERO, CRD42019131733
Cyclical helping hands: seasonal tailwinds differentially affect migrating Oriental Storks (Ciconia boyciana) travel speed
Authors: Fan Shujuan , Zhao Qingshan , Li Hongbin , Zhu Baoguang , Dong Shubin , Xie Yanbo , Cao Lei , Fox Anthony David 
Published: April 2020

Abstract
Background
The Oriental Stork (Ciconia boyciana) breeds in southeastern Siberia and parts of northeast China, and winters mainly in southeast China. Although the autumn migration pattern of Oriental Storks has been previously described, differences between spring and autumn migration travel speed in relation to wind assistance were unknown.

Methods
Using GPS/GSM transmitters, we tracked the full migrations of 18 Oriental Storks during 2015‒2018 to compare differences in autumn and spring migration patterns, and combined the satellite telemetry data with the National Center for Environmental Prediction Reanalysis data to explain the relationship between 850 mbar wind vectors and seasonal differences in travel speed.

Results
Differences in tailwinds contributed to significant differences in daily average Oriental Storks travel speed in spring (258.11 ± 64.8 km/day) compared to autumn (172.23 ± 49.7 km/day, p < 0.001). Storks stopped significantly more often in autumn than spring (1.78 ± 1.1 versus 1.06 ± 0.9, p < 0.05), but stopover duration (15.52 ± 12.4 versus 16.30 ± 15.1 days, respectively, p = 0.3) did not differ significantly. Tailwinds at 850 mbar pressure level (extracted from the National Center of Environmental Prediction Reanalysis data archive) significantly affected daily flying speed during spring and autumn migration. Tailwind conditions in spring (mean 4.40 ± 5.6 m/s) were always more favourable than in autumn when they received no net benefit (0.48 ± 5.6 m/s, p < 0.001). Despite mean spring migration duration being less than autumn (27.52 ± 15.9 versus 32.77 ± 13.4 days, p = 0.17), large individual variation meant that this duration did not differ significantly from each other.

Conclusions
For long distance migratory soaring birds (such as storks), relative duration of spring and autumn migration likely relates to the interaction between imperative for earliest arrival to breeding grounds and seasonal meteorological conditions experienced en route.
Wild bee distribution near forested landscapes is dependent on successional state
Authors: Odanaka Katherine A. , Rehan Sandra M. 
Published: April 2020

Abstract
Background
Forested landscapes are valuable sources of ecosystem services especially in areas dedicated to intense agricultural activities. Distance from forest margin is known to influence the wild bee community in the landscape surrounding forested patches. Yet little is known regarding how bee communities distribute themselves in landscapes that exhibit different forest successional states.

Methods
We examined how land use type and distance from the forest edge affect the abundance and richness of the wild bee community across four forest successional states. Bees were collected in sites representing four stages of forest succession and analyzed using generalized linear mixed models with negative binomial distributions.

Results
Wild bee diversity is reduced in forested environments that maintain dense stands of trees and high canopy cover. Additionally, distance from the forest edge was an important factor determining wild bee distribution in successional stages adjacent to forest edges. Furthermore, we found that bees maintain high specificity for distinct successional states and distances.

Conclusions
Our results demonstrate how different successional stages can harbor different bee species and highlight the ability of microhabitats to act as reservoirs of bee diversity in and around forest margins. Furthermore, we found that maximizing successional patchiness across forested landscapes increases the amount of available habitat that can support a diverse suite of bees with different nesting biologies and behaviors.
Non-iterative image reconstruction from sparse magnetic resonance imaging radial data without priors
Authors: Zeng Gengsheng L. , DiBella Edward V. 
Published: April 2020

AbstractThe state-of-the-art approaches for image reconstruction using under-sampled k-space data are compressed sensing based. They are iterative algorithms that optimize objective functions with spatial and/or temporal constraints. This paper proposes a non-iterative algorithm to estimate the un-measured data and then to reconstruct the image with the efficient filtered backprojection algorithm. The feasibility of the proposed method is demonstrated with a patient magnetic resonance imaging study. The proposed method is also compared with the state-of-the-art iterative compressed-sensing image reconstruction method using the total-variation optimization norm.
Multiple risk factors affecting childhood psychosocial dysfunction in primary school Egyptian children
Authors: Soliman Eman S. , Mahdy Rehab S. , Fouad Heba A. , Abbas R. A. , Fayed Amel 
Published: April 2020

Abstract
Background
Childhood psychosocial dysfunction (CPD) is an important cause of morbidity among children, and its frequency in primary care is growing. The information about its prevalence and risk factors is weak in many developing countries. The study aims to determine the prevalence of psychosocial problems among primary school children and identify the risk factors associated with childhood psychosocial dysfunction.

Results
A cross-sectional study was conducted on 368 primary school children aged 6–12 years. About (19.0%) of the studied sample had probable CPD according to Strengths and Difficulties Questionnaire (SDQ). CPD was statistically associated with older age group, male sex, and low social class.
The association between biological and medical risk factors of the studied group and CPD showed statistical significant relations between CPD and low body weight (n = 35, 50.7%), maternal history of problems with pregnancy (n = 26, 66.47%), history of receiving medications during pregnancy (n = 13, 86.7%), abnormal general condition of baby at birth (n = 57, 16.2%), family history of mental disorders (n = 2, 100%), medical history of congenital diseases (n = 9, 90%), acute medical disorders (n = 29, 90.6%), chronic diseases, receiving medications (n = 22, 91.7%), and exposure to trauma (n = 27, 84.4%).
Also, The association between psychosocial risk factors and CPD revealed high statistical significant relation between CPD among the studied children and presence of family problems (n = 33, 62.3%), living with single parent (n = 15, 71.4%), parent(s) death (n = 12, 63.2%), major changes in the family (n = 39, 79.6%), parent(s) smoking status (n = 22, 51.2%), and parent(s) addiction (n = 4, 100%).
Moreover, there was statistical significant relation between CPD among the studied children and poor academic achievement (n = 19, 27.5%), problems with teachers (n = 25, 33.3%), problems with peers (n = 22, 51.2%), and exposure to violence (n = 56, 22.4%).

Conclusions
Psychosocial dysfunction is common among Egyptian school children. It is associated with many risk factors. Hence, mental health services should be incorporated into primary health care facilities and school health program. Also, training of family physicians and primary health care providers is crucial.
Molecular phylogenetic analysis of Pulmonata (Mollusca:
Gastropoda) on the basis of Histone-3 gene
Authors: Ayyagari Vijaya Sai , Sreerama Krupanidhi 
Published: April 2020

Abstract
Background
In the present study, phylogenetic relationships within
Heterobranchia in particular to Pulmonata were evaluated by means of Histone-3
(H3) gene sequence information. H3 gene is a slow evolving marker and is useful
in resolving the deep level relationships. This is the first study to report the
phylogeny of Pulmonata with more number of representatives from the group on the
basis of H3 gene.

Results
The major groups within Heterobranchia viz. Lower Heterobranchia,
Opisthobranchia, and Pulmonata were non-monophyletic. A few of the pulmonate
groups’ viz. Planorbidae, Lymnaeidae, Siphonariidae, Veronicellidae, and
Stylommatophora were recovered as monophyletic. The concepts of Eupulmonata and
Geophila were not observed in the present study.

Conclusions
The present study was undertaken with an objective to study the
phylogeny of Pulmonata reconstructed on the basis of H3 gene and its ability to
resolve the deeper divergences in Pulmonata. However, the resolution at the
deeper nodes is limited. There is a good resolution at the level of genera. In
the future, inclusion of more number of taxa with increased sequence length of
H3 marker may yield resolved topologies that may shed more insights into the
phylogeny of Pulmonata.
Extending the vulnerability–stress model of mental disorders: three-dimensional NPSR1 × environment × coping interaction study in anxiety
Authors: Schiele Miriam A. , Herzog Katharina , Kollert Leonie , Schartner Christoph , Leehr Elisabeth J. , Böhnlein Joscha , Repple Jonathan , Rosenkranz Karoline , Lonsdorf Tina B. , Dannlowski Udo , Zwanzger Peter , Reif Andreas , Pauli Paul , Deckert Jürgen , Domschke Katharina 
Published: April 2020

BackgroundThe general understanding of the ‘vulnerability–stress model’ of mental disorders neglects the modifying impact of resilience-increasing factors such as coping ability.AimsProbing a conceptual framework integrating both adverse events and coping factors in an extended ‘vulnerability–stress–coping model’ of mental disorders, the effects of functional neuropeptide S receptor gene (NPSR1) variation (G), early adversity (E) and coping factors (C) on anxiety were addressed in a three-dimensional G × E × C model.MethodIn two independent samples of healthy probands (discovery: n = 1403; replication: n = 630), the interaction of NPSR1 rs324981, childhood trauma (Childhood Trauma Questionnaire, CTQ) and general self-efficacy as a measure of coping ability (General Self-Efficacy Scale, GSE) on trait anxiety (State-Trait Anxiety Inventory) was investigated via hierarchical multiple regression analyses.ResultsIn both samples, trait anxiety differed as a function of NPSR1 genotype, CTQ and GSE score (discovery: β = 0.129, P = 3.938 × 10−8; replication: β = 0.102, P = 0.020). In A allele carriers, the relationship between childhood trauma and anxiety was moderated by general self-efficacy: higher self-efficacy and childhood trauma resulted in low anxiety scores, and lower self-efficacy and childhood trauma in higher anxiety levels. In turn, TT homozygotes displayed increased anxiety as a function of childhood adversity unaffected by general self-efficacy.ConclusionsFunctional NPSR1 variation and childhood trauma are suggested as prime moderators in the vulnerability–stress model of anxiety, further modified by the protective effect of self-efficacy. This G × E × C approach – introducing coping as an additional dimension further shaping a G × E risk constellation, thus suggesting a three-dimensional ‘vulnerability–stress–coping model’ of mental disorders – might inform targeted preventive or therapeutic interventions strengthening coping ability to promote resilient functioning.