bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, Predictors, and Disease Activity of Sacroiliitis Among Patients with Crohn’s Disease
Authors: Levine Irving , Malik Fardina , Castillo Gabriel , Jaros Brian , Alaia Erin , Ream Justin , Scher Jose U , Hudesman David , Axelrad Jordan 
Published: August 2020

AbstractBackgroundSacroiliitis is an inflammatory arthritis of the sacroiliac joints and is associated with inflammatory bowel disease (IBD). Yet, sacroiliitis often goes undiagnosed in IBD, and the clinical association between IBD disease activity and sacroiliitis is not well established. Patients with Crohn’s disease (CD) often receive magnetic resonance enterography (MRE) to assess disease activity, affording clinicians the opportunity to evaluate for the presence of sacroiliitis. We aimed to identify the prevalence and disease characteristics associated with sacroiliitis in CD patients undergoing MRE.MethodsAll CD patients undergoing MRE for any indication between 2014 and 2018 at an IBD referral center were identified. The MREs were reviewed for the presence of sacroiliitis based on bone marrow edema (BME) and structural lesions. We analyzed demographics, IBD characteristics, clinical and endoscopic disease activity, and management between CD patients with and without sacroiliitis.ResultsTwo hundred fifty-eight patients with CD underwent MRE during the study period. Overall, 17% of patients had MR evidence of sacroiliitis, of whom 73% demonstrated bone marrow edema. Female gender, back pain, and later age of CD diagnosis were associated with sacroiliitis (P = 0.05, P &lt; 0.001, P = 0.04, respectively). Disease location and CD therapy were not associated with sacroiliitis on MRE. Clinical, endoscopic, and radiographic disease activity were not associated with sacroiliitis on MRE.ConclusionSacroiliitis is a common comorbid condition in CD. With limited clinical clues and disease characteristics to suggest sacroiliitis, physicians may utilize MRE to identify sacroiliitis, especially in CD patients with back pain.
Clinical Features, Replication Competence, and Innate Immune Responses of Human Adenovirus Type 7 Infection
Authors: Chen Qigao , Liu Jun , Liang Weiwen , Chen Yi , Dou Min , Liu Zhongmin , Chen Yuan , Zheng Zhongli , Zhu Bing , Lin Yongping 
Published: August 2020

AbstractBackgroundEpidemiologic reports suggest that the most severe or fatal adenoviral disease in children might be associated with human adenovirus (HAdV) type 7. However, the pathogenesis of HAdV-7–induced severe disease remains poorly understood.MethodsHAdV-3 and HAdV-7 replication kinetics and the host response to infection were compared using ex vivo human lung tissue cultures. Furthermore, cytokine and chemokine levels and the presence of adenovirus DNA in the serum of hospitalized children infected with HAdV-7 (n = 65) or HAdV-3 (n = 48) were measured (using a multiplex immunoassay and Taqman real-time polymerase chain reaction, respectively).ResultsAmong 471 HAdV-positive specimens, HAdV-3 or HAdV-7 was the most prevalent genotype during 2014–2016 or 2018, respectively. The incidence of severe pneumonia was higher in HAdV-7–infected than in HAdV-3–infected individuals (30.1% vs 4.5%, respectively). HAdV-7 replicated more efficiently than HAdV-3 ex vivo. Interferon-induced protein 10, interleukin 6, and monocyte chemoattractant protein 1 levels were significantly higher in HAdV-7–infected than in HAdV-3–infected children. Adenovirus DNA was detected in serum samples from 40% and 4.2% of HAdV-7– and HAdV-3–infected children, respectively. Furthermore, viremia was strongly associated with severe clinical presentations.ConclusionsThe pathogenesis of HAdV-7–induced severe disease was probably associated with high replication competence and hyperinflammatory responses. The detection of adenovirus DNA in blood may be useful in assessing risk for severe disease.
Phylogenomics of the Leaf-Footed Bug Subfamily Coreinae (Hemiptera: Coreidae)
Authors: Forthman Michael , Miller Christine W , Kimball Rebecca T 
Published: August 2020

AbstractBaits targeting invertebrate ultraconserved elements (UCEs) are becoming more common for phylogenetic studies. Recent studies have shown that invertebrate UCEs typically encode proteins—and thus, are functionally different from more conserved vertebrate UCEs—and can resolve deep divergences (e.g., superorder to family ranks). However, whether invertebrate UCE baits have the power to robustly resolve relationships at shallower phylogenetic scales has been generally limited to investigations within the Coleoptera and Hymenoptera; thus, there are many invertebrate UCE baits that remain to be tested at shallower levels (i.e., tribes and congeners). Here, we assessed the ability of a recently designed Hemiptera UCE bait set to reconstruct more recent phylogenetic relationships in the largest leaf-footed bug subfamily, the Coreinae (Hemiptera: Coreidae), using a taxon-rich sample representing 21 of the 32 coreine tribes. Many well-supported, novel relationships were congruent in maximum likelihood and summary coalescent analyses. We also found evidence for the para- and polyphyly of several tribes and genera of Coreinae, as well as the subfamilies Coreinae and Meropachyinae. Our study, along with other recent UCE studies, provides evidence that UCEs can produce robust and novel phylogenetic hypotheses at various scales in invertebrates.
Bias at warp speed: how AI may contribute to the disparities gap in the time of COVID-19
Authors: Röösli Eliane , Rice Brian , Hernandez-Boussard Tina 
Published: August 2020

Abstract
The COVID-19 pandemic is presenting a disproportionate impact on minorities in terms of infection rate, hospitalizations, and mortality. Many believe artificial intelligence (AI) is a solution to guide clinical decision-making for this novel disease, resulting in the rapid dissemination of underdeveloped and potentially biased models, which may exacerbate the disparities gap. We believe there is an urgent need to enforce the systematic use of reporting standards and develop regulatory frameworks for a shared COVID-19 data source to address the challenges of bias in AI during this pandemic. There is hope that AI can help guide treatment decisions within this crisis; yet given the pervasiveness of biases, a failure to proactively develop comprehensive mitigation strategies during the COVID-19 pandemic risks exacerbating existing health disparities.
Comprehensive Analyses of the Complete Mitochondrial Genome of Figulus binodulus (Coleoptera: Lucanidae)
Authors: Lee Jungmo , Park Jonghyun , Xi Hong , Park Jongsun 
Published: August 2020

Abstract
Figulus binodulus Waterhouse is a small stag beetle distributed in East Asia. We determined the first mitochondrial genome of F. binodulus of which is 16,261-bp long including 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNAs, and a single large noncoding region of 1,717 bp. Gene order of F. binodulus is identical to the ancestral insect mitochondrial gene order as in most other stag beetle species. All of 22 tRNAs could be shaped into typical clover-leaf structure except trnSer1. Comparative analyses of 21 Lucanidae mitochondrial genomes was conducted in aspect of their length and AT-GC ratio. Nucleotide diversities analyses provide that cox1 and cox2 in Lucanidae are less diverse than those of Scarabaeoidea. Fifty simple sequence repeats (SSRs) were identified on F. binodulus mitochondrial genome. Comparative analysis of SSRs among five mitochondrial genomes displayed similar trend along with SSR types. Figulus binodulus was sister to all other available family Lucanidae species in the phylogenetic tree.
Genetic and morphological variation of Oxymycterus (Rodentia: Sigmodontinae) in the Brazilian Atlantic Forest
Authors: Peçanha Willian Thomaz , Quintela Fernando Marques , Althoff Sergio Luiz , Oliveira João Alves , Gonçalves Pablo Rodrigues , Jung Diego Marques Henriques , Christoff Alexandre Uarth , Gonçalves Gislene Lopes , Freitas Thales Renato Ochotorena 
Published: August 2020

Abstract
We present a new assessment of the genetic and morphological variation within Oxymycterus quaestor Thomas, 1903, which currently includes the junior synonyms O. judex Thomas, 1909 and O. misionalis Sanborn, 1931. We integrate distinct lines of evidence, including variation of mitochondrial (Cytochrome b [Cytb]) and nuclear (intron 7 of beta fibrinogen gene [Fgb]) sequences, and the assessment of skull quantitative traits based on geometric morphometrics, throughout the Atlantic Forest of Southeastern-Southern Brazil, Argentina, and Paraguay. Phylogenetic relationships based on Cytb indicate that O. quaestor is structured in four well-supported clades (lineages A–D), one of them (lineage C) including topotypes of a previously associated nominal form (O. judex). However, these Cytb lineages exhibit lower levels of differentiation based on the Fgb locus, and are not recovered in the genealogies of this nuclear marker, representing a case of mitonuclear discordance. The Cytb lineages also broadly overlapped in the morphospace both in skull shape and size, which sustain the current wider concept of O. quaestor as one single young species (0.947 Myr) that is recently expanding, and ultimately branching out, in the Atlantic Forest.
Change in Pain Status and Subsequent Opioid and Marijuana Use Among Long-Term Adult Survivors of Childhood Cancer
Authors: Huang I-Chan , Alberts Nicole M , Buckley Merrion G , Li Zhenghong , Ehrhardt Matthew J , Brinkman Tara M , Allen Jennifer , Krull Kevin R , Klosky James L , Greene William L , Srivastava D Kumar , Robison Leslie L , Hudson Melissa M , Anghelescu Doralina L 
Published: August 2020

Abstract
We evaluated pain status change and associations with subsequent opioid/marijuana use among 1208 adult survivors of childhood cancer. Pain status and opioid/marijuana were self-reported at baseline and follow-up evaluation (mean interval = 4.2 years). Over time, 18.7% of survivors endorsed persistent/increasing significant pain; 4.8% and 9.0% reported having used opioids and marijuana at follow-up. Persistent/increased (vs none/decreased) pain, persistent/increased (vs none/decreased) anxiety, and lack of health insurance increased odds of subsequent opioid use by 7.69-fold (95% confidence interval [CI] = 3.71 to 15.95), 2.55-fold (95% CI = 1.04 to 6.24), and 2.50-fold (95% CI = 1.07 to 5.82), respectively. Persistent/increased (vs none/decreased) depression increased odds of subsequent marijuana use by 2.64-fold (95% CI = 1.10 to 6.33).
Expression Profiling of Primary and Recurrent Glioblastomas Reveals a Reduced Level of Pentraxin 3 in Recurrent Glioblastomas
Authors: Petterson Stine Asferg , Sørensen Mia Dahl , Kristensen Bjarne Winther 
Published: August 2020

Abstract
Glioblastomas (GBM) are highly infiltrative tumors and despite intensive treatment tumor recurrence is inevitable. The immune microenvironment in recurrent GBM is poorly characterized, but it is potentially influenced by therapeutic interventions with surgery, radiotherapy, and chemotherapy. The aim of this study was to obtain a deeper insight in the immune microenvironment in primary and recurrent GBM. Primary and recurrent glioblastoma samples from 18 patients were identified and expression profiling of 770 myeloid innate immune-related markers was performed. Leukemia inhibitory factor and pentraxin 3 were expressed at lower levels in recurrent tumors. Using in silico data and immunohistochemical staining, this was validated for pentraxin 3. Both high leukemia inhibitory factor and pentraxin 3 expression appeared to be associated with shorter survival in primary and recurrent GBM using in silico data. In primary GBM, gene set analysis also showed higher expression of genes involved in metabolism, extracellular matrix remodeling and complement activation, whereas genes involved in T cell activation and checkpoint signaling were expressed at higher levels in recurrent GBM. The reduced level of pentraxin 3 in recurrent glioblastomas and the gene set analysis results suggest an altered microenvironment in recurrent GBM that might be more active.
Impact of Rebel Group Ideology on Wartime Sexual Violence
Authors: Sarwari Mehwish 
Published: August 2020

Abstract
Does rebel group ideology influence variation in wartime sexual violence? While existing studies have explored country-level and conflict-specific factors to explain wartime sexual violence, it is important to recognize that rebels vary in their characteristics and sexual violence behavior. Specifically, rebel groups differ in their values regarding gender equality. I argue that the ideological preferences held by rebels and their foreign supporters can influence sexual violence during armed conflict. Particularly, I make the claim that rebels influenced by a leftist ideology are less likely to commit wartime sexual violence, whereas religious groups, Islamist and non-Islamist, are more likely to perpetrate such violence. Using a statistical analysis to explore the effects of ideology of rebel groups on sexual violence during the period of 1989–2008, I find that leftist rebels commit lower levels of wartime sexual violence. Furthermore, findings reveal that leftist organizations that receive support from leftist third parties are less likely to perpetrate sexual violence. Religious rebels who receive support from conservative supporters, on the other hand, are more likely to commit sexual violence.
Economic Crises and Terrorism: Analyzing Competing Economic Pressures on Terrorism in Russia
Authors: Omelicheva Mariya , Webb Clayton 
Published: August 2020

AbstractThe prevailing academic consensus holds that economic hardship does not motivate terrorism. We argue that this academic consensus is misguided because it assumes a single causal pathway connecting the economy to terrorism. In addition, most tests rely on national-level macroeconomic measures of economic performance that are not well suited to capturing individual-level decision-making processes that motivate people to engage in political violence. We argue that shifts in economic performance have heterogeneous effects on terrorist activity. The suffering caused by economic hardship energizes pre-existing grievances and generates feelings of anger and resentment toward the government, making affected individuals susceptible to violent radicalization. Economic crises also increase opportunities for terrorist recruitment by weakening institutions for coping with the consequences of sharp economic downturns. On the other hand, the economic losses caused by crises reduce the resources available to terrorist groups. These competing pressures are difficult to observe at the national level and are not equally reflected in all measures of economic performance. We test these arguments using a novel dataset of terrorist attacks and terrorist crimes in the Russian federal subjects between 2008 and 2016. We find evidence to support opportunity- and resource-based arguments for terrorism. These findings suggest a need to rethink the academic consensus on terrorism and a need to problematize the theoretical and empirical approaches that brought us to the prevailing consensus.
Olive Schreiner, Marie Corelli and the Anxieties of Female Authorship
Authors: Gill Clare 
Published: August 2020

Abstract
This article explores the competing models of gendered authorship emerging from Marie Corelli’s multiple print encounters with Olive Schreiner. Where Schreiner is cast by Corelli as the modish darling of a snobbish literary intelligentsia, who is beloved by critics and ignored by readers, Corelli herself emerges from her writings about Schreiner as the democratic author par excellence, a writer for the people rather than the press. In spite of the clear common ground that bridged their experience as celebrity authors, Corelli, in her writings about Schreiner, sought only to elucidate the ideological and artistic gulf that she identified as existing between them. As this essay will show, Corelli’s public resistance to Schreiner was a strike not only against an unfair male literary system of which she perceived Schreiner to be an arbitrary beneficiary, but also a rejection of the rhetoric of literary value that emerged in Britain during the fin de siècle. What Corelli failed to understand was that to be a woman writer at this time, however successful, was to occupy an ambiguous position within dominant, masculinist discourses of artistic distinction. A fuller exploration of Schreiner and Corelli’s positions within and experiences of the late-Victorian literary marketplace not only reveals the frailty of Correlli’s oppositional construction in real terms, but also signals the extent to which it was their shared status as women writers that was the key determinant shaping their respective experiences of professional authorship.
Investigation of the Sterility of Diluent in Prefilled Syringes Used for Vaccine Reconstitution at Department of Defense Recruit Training Sites
Authors: Chao Chien-Chung , Zhang Zhiwen , Belinskaya Tatyana , Jiang Le , Morrison Brian J , Rivera Jose Garcia , Chen Hua-Wei , Ching Wei-Mei 
Published: August 2020

Abstract

Introduction
Measles, mumps, and rubella (MMR) and varicella (VAR) vaccines are the two vaccines administered in large recruit training sites (RTS) that require a single-use syringe to be prefilled with the diluent (ie water) before vaccine reconstitution. Since there are no preservatives in either MMR or VAR vaccines, it is critical to maintain the diluent sterile to ensure the sterility of the reconstituted vaccine. The Department of Defense/Defense Health Agency has instructions on reconstitution of lyophilized vaccines and guidelines for their storage. Vaccine manufacturers provide instructions on how to properly store the diluent. However, there is no clear guidance or standard operating procedures regarding the best practice for preparation and storage of the syringes prefilled with diluent. Various RTS across all four services have their respective routines to best fit their vaccination requirements. Currently, there are no available data on the sterility status of the diluent prepared using these various routines before they are used to reconstitute vaccines.

Materials and Methods
We investigated the sterility of the diluent (ie water) in prefilled syringes prepared using routines practiced at various RTS. Diluent was drawn up into single syringes and was kept under various conditions (4 °C or room temperature for overnight up to 24 hours) used by various RTS. At indicated time, diluent was injected into sterile vials and the sterility of the diluent was determined by monitoring the presence/growth of bacteria (including aerobic bacteria, mycoplasma, and an obligate intracellular bacterium, Coxiella burnetii), fungi, and viruses for up to 21 days after inoculation into proper and specific culture media. Both traditional cell culture and molecular assays were used to demonstrate the presence or absence of contamination that may compromise the sterility of the diluent.

Results
Our results demonstrate that the diluent, after being drawn up to fill the syringe, maintains sterility after storage for overnight up to 24 hours at room temperature or 4 °C with or without recapping the syringes, suggesting that current vaccine reconstitution routines practiced at large military RTS are safe.

Conclusions
Our results demonstrate that in spite of variations in current practices used in various RTS, the diluent in the prefilled syringe tested from each site maintains its sterility and was determined to be safe for use in military health system-wide vaccine reconstitution.
The Importance of Validating Sleep Behavior Models for Fatigue Management Software in Military Aviation
Authors: Paul Michel A , Hursh Steven R , Love Ryan J 
Published: August 2020

Abstract

Introduction
The propensity for air mobility missions to exhaust aircrews is strongly dependent on operational tempo. Most flying is performed during periods of low to moderate operational tempo, but a major flight safety risk can emerge when operational tempo becomes very high. This risk can be managed by software tools that contain fatigue and sleep behavior modeling, but optimization/validation of the model using the specific target population is required to ensure that the modeled predictions are accurate. The goal of the study was to validate the sleep behavior model settings for a fatigue modeling tool that is used within the RCAF, the Fatigue Avoidance Scheduling Tool, taking into account the organizational requirements for pre- and postflight routines, especially within the Air Mobility force.

Materials and methods
Four Royal Canadian Air Force Air Mobility Squadrons from Canadian Forces Base Trenton took part in this trial over a 3-month period (May 3 to August 21, 2016). All 22 missions of the trial included long-range transmeridian flights. All members of the participating aircrew wore wrist actigraphs to measure their sleep. We compared cognitive effectiveness modeling scenarios (preharmonization) based on the SAFTE-FAST sleep behavior model with its default settings against cognitive effectiveness modeling scenarios based on actigraphically-measured sleep. The measured sleep was then harmonized against the predicted sleep to optimize accuracy of the sleep behavior algorithm. During the harmonization process, the “Autosleep” prediction settings were optimized to match the actigraphically-measured sleep timings.

Results
Prior to the harmonization effort, the sleep behavior algorithm overpredicted the sleep obtained by CAF Aircrews. The most significant adjustment to the sleep behavior model was the increase in commute time to account for briefing, flight planning, debriefing, and postflight activities. Following harmonization, the sleep behavior model provided nearly perfect estimates of overall fatigue risk against missions modeled with actigraphically-measured sleep. For both measured and predicted sleep, most of the time in flight was in a low-fatigue, high-cognitive effectiveness state (90%–95% cognitive effectiveness).

Conclusions
Current Fatigue Risk Management Systems require accurate fatigue and sleep behavior modeling, which can only be achieved by studying specific target populations to determine their culture of work/rest routines, and optimizing sleep behavior model settings accordingly.
Subcutaneous Perforation of Recurrent Gastric Fistula After Abdominoplasty with Scar Revision
Authors: DeSoucy Erik S , Nelson Vincente S 
Published: August 2020

AbstractThis case represents an unusual, and previously unreported, complication of delayed leakage of gastric contents into the subcutaneous tissues 2 years after division of a gastrostomy tube tract during abdominoplasty. Our patient required urgent exploration for contamination control and closure of the fistula and recovered fully. Persistent gastrocutaneous fistula is uncommon in adults and even less common is recannulization of a fistula track after initial closure. A thorough review of operative history and comparison to previous imaging were crucial for appropriate diagnosis and operative planning. Formal closure of gastrostomy tube sites during scar revision and abdominoplasty may help prevent the complication of delayed gastrostomy tube tract rupture into the subcutaneous tissues.