bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myocardial Injury in Post Mortem Biopsies of Patients with COVID-19
Authors: Hartmann Camila , Miggiolaro Anna Flavia dos Santos , Junior Jarbas da Silva Motta , Carstens Lucas Baena , De Paula Caroline Busatta Vaz , Nunes Larissa Hermann de Souza , Marques Gustavo Lenci , Moura Lidia Zytinsky , Neto Jose Rocha Faria , de Noronha Lucia , Baena Cristina Pellegrino 
Published: July 2020

Abstract
Background: Myocardial injury is significantly and independently associated with mortality in COVID-19 patients. However, the pathogenesis of myocardial injury in COVID-19 is still not clear, and cardiac involvement by SARS-CoV-2 remains a major challenge worldwide.Aim: This histopathological and immunohistochemical study seeks to clarify the pathogenesis of myocardial injury in COVID-19.Methods: Postmortem minimally invasive autopsies were performed in two patients who died from COVID-19, and the myocardium samples were compared to a control patient. Immunohistochemistry (IHC) staining was performed using monoclonal antibodies against the following targets: caspase-1, ICAM-1, TNF-α, IL-4, IL-6, CD163, TGF-β, MMP-9, type 1 and type 3 collagen.Results: The histopathological analysis showed severe pericellular interstitial edema surrounding each of the cardiomyocytes. The IHC analysis showed increased expression of caspase-1, ICAM-1, IL-4, IL-6, CD163, MMP-9 and type 3 collagen in the COVID-19 patients compared to the control. On the other hand, no difference from the control was observed in expression of TNF-α, TGF-β and type 1 collagen. ﻿Conclusion: Our findings point to a pathogenesis related with pyroptosis leading to endothelial disfunction. The subsequent inflammation with associated interstitial edema could explain the myocardial disfunction and arrythmias in COVID-19 patients. The presence of Th2 response, MMP-9 and type-3 collagen suggests progression to myocardial fibrosis in the long term.
Do work ability and well-being matter for return to work? Cut-off points for the Work Ability Index and Life Satisfaction Questionnaire among women with long-term musculoskeletal pain
Authors: Rashid Mamunur , Heiden Marina , Nilsson Annika , Kristofferzon Marja-leena 
Published: July 2020

Abstract
Background
To determine whether work ability and well-being predict return to work (RTW) among women with long-term neck/shoulder and/or back pain at 1-year follow-up, and to assess the ability of the Work Ability Index (WAI) and Life Satisfaction Questionnaire (LiSat-11) to discriminate between those who did RTW and those who did not RTW (NRTW).
Methods
A survey was sent to 600 women receiving sick leave (SL) benefits from the Swedish Social Insurance Agency. In total, 208 women responded at baseline, and 141 at a 1-year follow-up. To identify whether work ability and well-being predicted RTW, multiple logistic regression analyses were performed with and without adjustment for type of work and pain intensity. To assess the discriminative ability of the WAI and LiSat-11 for women who did RTW and those who did NRTW, receiver operating characteristic curves were fitted.
Results
Work ability predicted RTW, and the results remained significant after adjusting for type of work and pain intensity (OR 1.12, 95% CI: 1.04–1.22). Well-being was not significant. The WAI at baseline adequately discriminated between RTW and NRTW after one year (AUC 0.78, 95% CI: 0.70–0.86), but the LiSat-11 did not.
Conclusions
Our results indicate that work ability is an important factor for RTW among women on SL for long-term neck/shoulder and/or back pain. The findings also indicate that the WAI, but not the LiSat-11, is able to discriminate between RTW and NRTW in the population under study. The WAI may be used to identify women at risk of NRTW.
Establishment of a Model for Predicting the Recurrence of Recurrent Acute Pancreatitis in A Short Period of Time
Authors: Yang Bo , Li Peiyun , Liu Honglan , Bai Xuesong , Yu Yijun 
Published: August 2020

Abstract
Background Little is known about what factors affect recurrence of recurrent acute pancreatitis (RAP) in a short-term. We performed a retrospective study of patients with RAP, and used non-invasive and quantitative biomarkers to establish a predictive model, so as to provide a basis for effectively predicting and preventing recurrence of RAP. MethodsWe performed a retrospective study of 261 RAP patients admitted to Dazhou Central Hospital from January 2008 through December 2018. The short-term group (n=138) and the long-term group (n=123) were compared. Eight clinical patient characteristics and past medical history were collected from admission records. The prediction model was developed by independent risk factors，and the model to predict the effects were confirmed by the area under the ROC cure．ResultsThe study found that β2-microglobulin (β2-MG) (OR, 0.534; 95% CI, 0.329 to 0.866) and C-reactive protein (CRP) (OR, 1.01; 95% CI, 1.002 to 1.017) were the independent predictors of short-term recurrence. Based on these Independent risk factors，a predicted model for short-term recurrence in RAP patients was constructed．The model was L=β2-MG -0.016BCRP. The AUC for model was 0.651 and the optimal cut-off value was 0.7414, with a sensitivity of 65.9%and a specificity of 63.4%.ConclusionsA new biomarker-based model for predicting risk of short-term recurrence in patients with RAP was satisfactorily developed. The model utilizing β2-MG and CRP may assist physicians in patient education and decision-making when preventing from recurrent attacks with RAP.
Laparoscopic Versus Open Feeding Jejunostomy Insertion in Oesophagogastric Cancer
Authors: Mastoridis Sotiris , Bracalente Giada , Hanganu Bianca , Neccia Michela , Giuliani Antonio , Gillies Richard , Marshall Robert , Maynard Nicholas , Sgromo Bruno 
Published: July 2020

Abstract
Background

Jejunal feeding is an invaluable method by which to improve the nutritional status of patients undergoing neoadjuvant and surgical treatment of oesophageal malignancies. However, the insertion of a feeding jejunostomy can cause significant postoperative morbidity. The aim of this study is to compare the outcomes of patients undergoing placement of feeding jejunostomy by conventional laparotomy with an alternative laparoscopic approach.
Methods

A retrospective review of data prospectively collected at the Oxford Oesophagogastric Centre between August 2017 and July 2019 was performed including consecutive patients undergoing feeding jejunostomy insertion.
Results

In the study period, 157 patients underwent jejunostomy insertion in the context of oesophageal cancer therapy, 126 (80%) by open technique and 31 (20%) laparoscopic. Pre-operative demographic and nutritional characteristics were broadly similar between groups. In the early postoperative period jejunostomy-associated complications were noted in 54 cases (34.4%) and were significantly more common among those undergoing open as compared with laparoscopic insertion (38.1% vs 19.3%, P = 0.049). Furthermore, major complications were more common among those undergoing open insertion, whether as a stand-alone procedure or in conjunction with laparoscopic staging (n = 11/71), as compared with insertion at the time of oesophagectomy (n = 3/86, P = 0.011).
Conclusions

This report represents the largest to our knowledge single-centre comparison of open versus laparoscopic jejunostomy insertion in patients undergoing oesophagectomy in the treatment of gastroesophageal malignancy. We conclude that the laparoscopic jejunostomy insertion technique described represents a safe and effective approach to enteral access which may offer superior outcomes to conventional open procedures.
Association between breakfast skipping and metabolic outcomes with sex, age, and work status stratification
Authors: Heo Jun , Choi Won-Jun , Ham Seunghon , Kang Seong-Kyu , Lee Wanhyung 
Published: July 2020

Abstract
Background
The association between breakfast skipping and abnormal metabolic outcome remains controversial. Large study with stratified data is needed.
Objective
The aim of the current study was to investigate the relationship between abnormal metabolic outcomes and breakfast skipping with sex, age, and work status stratification.
Methods
We used data from the Korea National Health and Nutrition Examination Surveys from 2013–2018. A total of 21,193 (9,022 men and 12,171 women) participants were included in the final analysis. The risk of the increased total number of metabolic outcomes linked to breakfast skipping was estimated using the Poisson regression analysis with sex, work status, and age stratification.
Results
A total of 11,952 (56.4%) participants consumed breakfast regularly. The prevalence of abnormal metabolic outcomes was higher among those with irregular breakfast consumption habits. In the irregular breakfast eating group, young men in the working population demonstrated a higher risk of metabolic syndrome after adjustment (odds ratio, 1.15; 95% confidence interval, 1.06–1.25). We found a similar association among middle-aged men in the working population (odds ratio, 1.11; 95% confidence interval, 1.05–1.19).
Conclusions
The risk of abnormal metabolic outcomes was significant in young men in the working population. Further studies are required to understand the association between specific working conditions (working hours or shift working) and breakfast intake status and the risk of metabolic outcomes
Corrosion Behavior and Failure Mechanism of Rock Bolt(Cable) in Underground Coal Mine
Authors: Wang Qiong , Ren Aiwu , Yin Songyang , Li Mengyi 
Published: July 2020

Abstract
Premature failure of rock bolt (cable) due to stress corrosion cracking (SCC) is a phenomenon that has reported to occur in underground environments. In this study, the corrosion behavior and failure mechanism of rock bolt (cable) samples obtained from underground coal mine were examined and discussed. Macroscopic observation and weight loss test were carried out for the corrosion characteristics of the bolts without failure. It is found the corrosion form is uniform corrosion for the bolts with short service time (S-1, S-2). But for the bolts with longer service time (S-3, S-4 and S-5), experience different degrees of pitting corrosion and the number of corrosion spots on the surface of the sample increases with increase of the service time. The corrosion amount of different parts of the bolts shows the rule of bolt head > bolt end > free section, and the corrosion amount increases year by year with the service time, but the corrosion growth rate is fast in the early stage and slows down in the later stage. At the same time, the failure mechanism of the failure sample S-6, which has been in service for 6 years, was analyzed with macro and micro methods. The results show that S-6 have been in O, Cl and S surrounding rock environment for a long time, resulting serious pitting corrosion and spalling of the surface material of the steel strand, which reduces the outer diameter of the rock cable and its bearing capacity, finally leads to the instantaneous SCC fracture of the sample S-6.
Delirium in older patients undergoing aortic valve replacement Incidence, predictors, and cognitive prognosis
Authors: Humbert Marc , Büla Christophe J , Müller Olivier , Krief Hélène , Monney Pierre 
Published: July 2020

Abstract
Background: To determine delirium incidence, predictors, and relationship with cognitive performance at 3-month follow-up in older patients undergoing aortic valve replacement (AVR).Methods: Patients (N=93) aged 70 years and older, undergoing transcatheter (TAVR, N=66) or surgical (SAVR, N=27) aortic valve replacement in an academic medical center were enrolled in this prospective cohort study. Delirium was assessed using the Confusion Assessment Method (CAM) on postoperative days 1, 2, 3, and 7. Data on patients’ socio-demographics, functional status (including instrumental activities of daily living (IADL), and surgical risk scores (including Society of Thoracic Surgeons (STS) risk score), were collected at baseline. Cognitive status was assessed with the Mini-Mental Status Exam (MMSE) and the Clock Drawing Test (CDT) at baseline and 3 months after AVR.Results: Delirium occurred in 21 (22.6%) patients, within the first three postoperative days in 95% (20/21) of the cases. Delirium incidence was lower in TAVR (13/66=20%) than SAVR (8/27=30%) patients, but this difference was not statistically significant (p=.298). Patients with delirium had lower baseline cognitive performance (median MMSE score 27.0±3.0 vs 28.0±3.0, p=.029), lower performance in IADL (7.0 vs 8.0, p=.038), and higher STS risk scores (4.7±2.7 vs 2.9±2.3, p=.020). In multivariate analyses, patients with intermediate (score>3 to ≤8) and high (score>8) STS scores had 4.3 (95%CI 1.2-15.1, p=.025) and 16.5 (95%CI 2.0-138.2, p=.010), respectively, higher odds of incident delirium compared to patients with low (score≤3) STS scores. At 3-month follow-up (N=77), patients with delirium still had lower MMSE score (27.0±8.0 vs 28.0±2.0, p=.007) but this difference did not remain significant once adjusting for baseline MMSE (β-coefficient 1.11, 95%CI [-3.03-0.80], p=.248).Conclusions: Delirium occurred in about one in five older patients undergoing AVR, almost essentially within the first three postoperative days. Beside cognitive performance, STS score could enhance the identification of high-risk older patients to better target preventative interventions.
Incidental Retroaortic Innominate Vein in a Patient with Acute Aortic Dissection
Authors: Sasaki Hideki , Harada Takashi , Ishitoya Hiroshi , Sasaki Osamu 
Published: July 2020

Abstract
BackgroundRetroaortic innominate vein is a rare anomaly. It has been reported in patients with congenital anomalies such as Tetralogy of Fallot or right aortic arch. However, isolated retroaortic innominate vein is quite rare.Case presentationA 63-year-old man was transferred to our institution because of Stanford type A acute aortic dissection. Incidentally, we noticed that the left innominate vein coursed under the aortic arch and was directed into the superior vena cava on computed tomography. We performed emergent hemiarch replacement. ConclusionsAttention must be paid to the cannulation site for venous uptake and the method of myocardial protection.
High-Expression of ROCK1 Modulates the Apoptosis of Lens Epithelial Cells in Age-Related Cataracts by Targeting p53 Gene
Authors: Hu Shanshan , Su Dongmei , Sun Lei , Wang Zhongying , Guan Lina , Liu Shanhe , Zhao Baowen , Liu Yong , Shi Cuige , Yu Jianbo , Ma Xu 
Published: July 2020

Abstract
Background: Age-related cataract (ARC) is a serious visual impairment disease, and its pathogenesis is unclear. This article aims to investigate the role of ROCK1 in the apoptosis of lens epithelial cells (LECs) in age-related cataracts. Methods: We collect anterior capsule samples from normal people, patients with age-related cataracts, young mice and naturally aging cataract mice. The Oxidative stress-induced apoptosis model was constructed by cultivating HLE-B3 cells with H2O2. MTT, Hoechst 33342, and TUNEL assay were performed to explore proliferation and apoptosis. HE assay was used to observe cell morphology. The gene and protein expression were assessed by quantitative real-time PCR, western blot, and immunohistochemical staining.Result: The results from the clinic and mice experiments showed that the numbers of lens epithelial cells from cataract individuals were less than the control individuals. In vitro, the apoptotic cells were increased in lens epithelial cells under H2O2 treatment. The ROCK1 protein level increased in the lens epithelial cells from age-related cataract patients and the old mice, respectively. Meanwhile, the up-regulation of the ROCK1 gene was associated with H2O2-induced HLE-B3 cells apoptosis. MTT and apoptosis assay showed ROCK1 was necessary in mediating H2O2-induced lens epithelial cells apoptosis through ROCK1 over-expression and knockdown experiment, respectively. Further investigation showed that p53 protein levels had been increased during ROCK1-mediated apoptosis in response to H2O2. Besides, ROCK1 phosphorylated p53 at ser15 to up-regulate its protein level. Conclusions: This study established the novel association of ROCK1/p53 signaling with lens epithelial cells apoptosis and age-related cataract genesis.
Development of a 38K Single Nucleotide Polymorphism Array and Application in Henomic Selection for Resistance Against Vibrio harveyi in Chinese Tongue sole, Cynoglossus Semilaevis
Authors: Lu Sheng , Zhou Qian , Chen Yadong , Liu Yang , Li Yangzhen , Wang Lei , Yang Yingming , Chen Songlin 
Published: August 2020

Abstract
Background: In recent years, the disease outbreak caused by Vibrio harveyi upset the booming development of the Chinese tongue sole (Cynoglossus semilaevis) farming industry. Genomic selection (GS) is a powerful method to improve the traits of interest, which has been proved in livestock and some fishes. Besides, the single nucleotide polymorphism (SNP) array is an efficient genotyping platform that can be used for genetic studies. To improve V. harveyi resistance in C. semilaevis, we firstly constructed a reference group of 1,572 individuals and investigated accuracies of four genomic methods (genomic best linear unbiased prediction (GBLUP), weighted GBLUP, BayesB, and BayesC) at predicting the genomic estimated breeding value (GEBV) using five-fold cross-validation and SNPs varying from 0.5 k to 500 k. Then, an SNP array was developed using the Affymetrix Axiom technology, and its accuracy in genotyping was evaluated by comparing SNPs generated by the array and by the re-sequencing technology. Finally, we selected 44 candidates as the parents of 23 families of C. semilaevis to evaluate the feasibility of the SNP array for GS.Results: all genomic methods outperformed the pedigree-based BLUP (ABLUP) when at least 50 k SNPs used for prediction, of which GBLUP resulted in better estimation than ABLUP when more than 1 k SNPs used. A 38 k SNP array, “Solechip No.1”, was developed with an average of 10.5 kb inter-spacing between two adjacent SNPs. The SNPs generated by the array and by the re-sequencing reached an average consistency of 94.8 %, of which 79.3 % of loci had a more than 90 % of the consistency. The survival rates of these 23 offspring families had a correlation of 0.706 with the family GEBVs (mid-parental GEBVs), and the average survival rate of the top five families in GEBVs (79.1 %) is higher than the bottom five families (58.1 %).Conclusion: GS is an efficient method to improve the V. harveyi resistance in C. semilaevis, and the SNP array “Solechip No.1” is a convenient and reliable tool for the Chinses tongue sole selective breeding practice.
Duodenal Perforation Caused Septic Shock: a Rare Case Combined With Coronavirus Disease 2019
Authors: Guo Huanhuan , Hu Jing , Li Yunxiang , Xiang Wei , Gan Quan 
Published: July 2020

Abstract
Background: Duodenal perforation is one of the rarer causes of acute abdomen in pregnancy, which is especially easy to be overlooked during the outbreak of 2019 novel coronavirus (2019-nCoV) after delivery.Case presentation: Here, we report a case of duodenal perforation-induced septic shock with coronavirus disease 2019 (COVID-19), and the patient underwent emergency laparotomy after reporting to the hospital management department under strict protection. Her recovery in postoperative period in Medical Intensive Care Unit (MICU) was uneventful and she was transferred to a designated hospital for treatment of COVID-19 5 days later.Conclusions: The establishment of emergency green channel for maternal health care, and timely and comprehensive multidisciplinary cooperation during the epidemic period, strengthen the standardized management of high-risk pregnancy, and better guarantee the safety of mothers and infants.
Hypophosphataemia in Critically Ill Adults and Children – A Systematic Review
Authors: Blaser Annika Reintam , Gunst Jan , Ichai Carole , Casaer Michael , Benstoem Carina , Besch Guillaume , Dauger Stephane , Fruhwald Sonja M , Hiesmayr Michael , Joannes-Boyau Olivier , Malbrain Manu LNG , Perez Maria-Helena , Schaller Stefan J , Man Angelique de , Starkopf Joel , Tamme Kadri , Wernerman Jan , Berger Mette M 
Published: July 2020

Abstract
Background: Phosphate is the main intracellular anion essential for numerous biological processes. Symptoms of hypophosphataemia are non-specific, yet potentially life-threatening. This systematic review process was initiated to gain a global insight into hypophosphataemia, associated morbidity and treatments. Methods: A systematic review was conducted (PROSPERO CRD42020163191). Nine clinically relevant questions were generated, seven for adult and two for paediatric critically ill patients, and prevalence of hypophosphataemia was assessed in both of these groups. We identified trials through systematic searches of Medline, EMBASE, Scopus, Cochrane Central Register of Controlled Trials, CINAHL, and Web of Science. Quality assessment was performed using the Cochrane risk of bias tool for randomized controlled trials and the Newcastle-Ottawa Scale for observational studies.Results: For all research questions, we identified 2727 titles in total, assessed 399 full texts, and retained 82 full texts for evidence synthesis, with 20 of them identified for several research questions. Only 3 randomized controlled trials were identified with two of them published only in abstract form, as well as 28 prospective and 31 retrospective studies, and 20 case reports. Relevant risk of bias regarding selection and comparability was identified for most of the studies. No meta-analysis could be performed. The prevalence of hypophosphataemia varied substantially in critically ill adults and children, but no study assessed consecutive admissions to intensive care.In both critically ill adults and children, several studies report that hypophosphataemia is associated with worse outcome (prolonged length of stay and the need for respiratory support, and higher mortality). However, there was insufficient evidence regarding the optimal threshold upon which hypophosphataemia becomes critical and requires treatment. We found no studies regarding the optimal frequency of phosphate measurements, and regarding the time window to correct hypophosphataemia. In adults, nutrient restriction on top of phosphate repletion in patients with refeeding syndrome may improve survival, although evidence is weak. Conclusion: Evidence on the definition, outcome and treatment of clinically relevant hypophosphataemia in critically ill adults and children is scarce and does not allow answering clinically relevant questions. High quality clinical research is crucial for the development of respective guidelines.