bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute redistribution of regional left ventricular work by cardiac resynchronization therapy determines long-term remodelling
Authors: Duchenne Jürgen , Aalen John M , Cvijic Marta , Larsen Camilla K , Galli Elena , Bézy Stéphanie , Beela Ahmed S , Ünlü Serkan , Pagourelias Efstathios D , Winter Stefan , Hopp Einar , Kongsgård Erik , Donal Erwan , Fehske Wolfgang , Smiseth Otto A , Voigt Jens-Uwe 
Published: January 2020

Abstract

Aims
Investigating the acute impact of cardiac resynchronization therapy (CRT) on regional myocardial work distribution in the left ventricle (LV) and to which extent it is related to long-term reverse remodelling.

Methods and results
One hundred and thirty heart failure patients, referred for CRT implantation, were recruited in our prospective multicentre study. Regional myocardial work was calculated from non-invasive segmental stress–strain loop area before and immediately after CRT. The magnitude of volumetric reverse remodelling was determined from the change in LV end-systolic volume, 11 ± 2 months after implantation. CRT caused acute redistribution of myocardial work across the LV, with an increase in septal work, and decrease in LV lateral wall work (all P &lt; 0.05). Amongst all LV walls, the acute change in work in the septum and lateral wall of the four-chamber view correlated best and significantly with volumetric reverse remodelling (r = 0.62, P &lt; 0.0001), with largest change seen in patients with most volumetric reverse remodelling. In multivariate linear regression analysis, including conventional parameters, such as pre-implant QRS morphology and duration, LV ejection fraction, ischaemic origin of cardiomyopathy, and the redistribution of work across the septal and lateral walls, the latter appeared as the strongest determinant of volumetric reverse remodelling after CRT (model R2 = 0.414, P &lt; 0.0001).

Conclusion
The acute redistribution of regional myocardial work between the septal and lateral wall of the LV is an important determinant of reverse remodelling after CRT implantation. Our data suggest that the treatment of the loading imbalance should, therefore, be the main aim of CRT.
The robotic thymectomy via the subxiphoid approach: technique and early outcomes
Authors: Kang Chang Hyun , Na Kwon Joong , Song Jae Won , Bae So Young , Park Samina , Park In Kyu , Kim Young Tae 
Published: January 2020

OBJECTIVES
Robotic thymectomy via the subxiphoid approach (RTX) is a recently introduced surgical approach. This study aimed to report on the surgical technique and early outcomes of RTX in our institute.

METHODS
RTX was performed using the 3-arm technique in the da Vinci robotic surgical system. The camera was inserted into a subxiphoid port, and 2 robotic arms were inserted in bilateral intercostal ports. A complete dissection of both cervical poles up to the thyroid gland was conducted, and bilateral phrenic nerves were identified in all cases. Radical combined resection of adjacent organs, including the lung, pericardium, phrenic nerve and the innominate vein, was performed if necessary. The resected specimen could be retrieved through the subxiphoid port site.

RESULTS
A total of 110 patients underwent RTX in our institute from October 2016 to August 2019. Thymoma was the most common diagnosis (60.9%), and the mean size of the tumours was 4.9 ± 2.4 cm. Combined resection was performed in the lung (n = 9, 8.1%), pericardium (n = 6, 5.5%) and innominate vein (n = 5, 4.5%). There were 2 minor postoperative complications (1.8%), and the mean length of hospital stay was 2.2 ± 1.4 days. For the cumulative sum curve analysis of the learning curve using operative time, 50 cases were necessary to gain proficiency.

CONCLUSIONS
RTX was a safe and feasible surgical approach, even in advanced thymic epithelial tumours. It should be considered one of the valuable surgical options in minimally invasive thymectomy.
Indication and prognostic significance of programmed ventricular stimulation in asymptomatic patients with Brugada syndrome
Authors: Asada Saori , Morita Hiroshi , Watanabe Atsuyuki , Nakagawa Koji , Nagase Satoshi , Miyamoto Masakazu , Morimoto Yoshimasa , Kawada Satoshi , Nishii Nobuhiro , Ito Hiroshi 
Published: January 2020

Abstract

Aims
To establish the indication for programmed ventricular stimulation (PVS) for asymptomatic patients with Brugada syndrome (BrS), we evaluated the prognostic significance of PVS based on abnormal electrocardiogram (ECG) markers.

Methods and results
One hundred and twenty-five asymptomatic patients with BrS were included. We performed PVS at two sites of the right ventricle with up to three extrastimuli [two pacing cycle lengths and minimum coupling interval (MCI) of 180 ms]. We followed the patients for 133 months and evaluated ventricular fibrillation (VF) events. Fragmented QRS (fQRS) and Tpeak-Tend (Tpe) interval were evaluated as ECG markers for identifying high-risk patients. Fragmented QRS and long Tpe interval (≥100 ms) were observed in 66 and 37 patients, respectively. Ventricular fibrillation was induced by PVS in 60 patients. During follow-up, 10 patients experienced VF events. Fragmented QRS, long Tpe interval, and PVS-induced VF with an MCI of 180 ms or up to two extrastimuli were associated with future VF events (fQRS: P = 0.015, Tpe ≥ 100 ms: P = 0.038, VF induction: P &lt; 0.001). However, PVS-induced VF with an MCI of 200 ms was less specific (P = 0.049). The frequencies of ventricular tachyarrhythmia events during follow-up were 0%/year with no ECG markers and 0.1%/year with no VF induction. The existence of two ECG factors with induced VF was strongly associated with future VF events (event rate: 4.4%/year, P &lt; 0.001), and the existence of one ECG factor with induced VF was also associated (event rate: 1.3%/year, P = 0.011).

Conclusion
We propose PVS with a strict protocol for asymptomatic patients with fQRS and/or long Tpe interval to identify high-risk patients.
Prognosis of incidental left bundle branch block
Authors: Zegard Abbasin , Okafor Osita , de Bono Joseph , Steeds Richard , Hudsmith Lucy , Stegemann Berthold , Jani Ayman , Marshall Howard , Holloway Ben , Leyva Francisco 
Published: January 2020

Abstract

Aims
Incidental left bundle branch block (iLBBB) is a frequent cause for cardiology referrals. In such instances, there is uncertainty as to its prognosis. We sought to determine the utility of cardiovascular magnetic resonance (CMR) in the risk stratification of patients with iLBBB.

Methods and results
Clinical events were collected in patients with iLBBB who had CMR. Controls had no cardiac symptoms or cardiac disease, a normal CMR scan and electrocardiogram. Amongst patients with iLBBB [n = 193, aged 62.7 ± 12.6 years (mean ± SD)], 110/193 (56.9%) had an abnormal phenotype (iLBBBCMR+) and 83/110 (43.0%) had a normal phenotype (iLBBBCMR−). Over 3.75 years (median; inter-quartile range: 2.7–5.5), iLBBBCMR+ had a higher total mortality [adjusted hazard ratio (aHR) 6.49, 95% confidence interval (CI) 1.91–22.0] and total mortality or major adverse cardiac events (MACEs; aHR 9.15, 95% CI 2.56–32.6) than controls (n = 107). In contrast, iLBBBCMR− had a similar risk of total mortality compared with controls, but total mortality or MACEs was higher (aHR 4.24, 95% CI 1.17–15.4; P = 0.028). Amongst iLBBB patients, both myocardial fibrosis (aHR 5.15, 95% CI 1.53–17.4) and left ventricular ejection fraction (LVEF)  ≤ 50% (aHR 3.88, 95% CI 1.67–9.06) predicted total mortality. Myocardial fibrosis plus LVEF ≤50% was associated with the highest risk of total mortality (aHR: 9.87, 95% CI 2.99–32.6) and total mortality or MACEs (aHR 3.98, 95% CI 1.73–9.11).

Conclusions
Outcomes in iLBBBCMR+ were poor whereas survival in iLBBBCMR− was comparable with controls. Myocardial fibrosis and LVEF &lt;50% had an additive effect on the risk of clinical outcomes. A CMR scan is pivotal in risk-stratifying patients with iLBBB.
Lifetime employment histories and their relationship with 10-year health trajectories in later life: evidence from England
Authors: Di Gessa Giorgio , Corna Laurie , Price Debora , Glaser Karen 
Published: January 2020

AbstractBackgroundEmployment histories influence health. However, most studies have so far investigated cross-sectional associations between employment histories and health, failing to recognize health as a dynamic process in later life.MethodsWe use Waves 3–8 of the English Longitudinal Study of Ageing, including retrospective information on respondents’ employment activities. We used dynamic hamming distances to summarize lifetime employment histories up to state pension age (64 for men and 59 for women). Multilevel growth curve models were then used to estimate the influence of lifetime employment histories on later life health trajectories over a 10-year period using quality of life (QoL), somatic health, and depression.ResultsNet of selection effect and a host of contemporaneous material and social resources, men who exited early started off with poorer health than those with continuous attachment to the labour market but had a very similar health profile by the end of the 10-year period considered. Among women, better somatic health and higher QoL were observed among those who had employment breaks for family care, and this health advantage was maintained over time. Lifetime employment histories are not related to depression for either men or women.ConclusionOverall, differences in health by employment histories level off only among men who left earlier and those continuously employed. Flexible arrangements for men in poor health who benefit from leaving the labour market early and supporting women who wish to take breaks for family care may help reduce health inequalities in later life.
Seasonal dynamics ofChironomus transvaalensispopulations and the microbial community composition of their egg masses
Authors: Sela Rotem , Halpern Malka 
Published: January 2020

ABSTRACTChironomids (Diptera; Chironomidae) are the most abundant insects in freshwater environments and are considered natural reservoirs of Vibrio cholerae. We monitored the annual dynamics of chironomid populations along with their microbiota in order to better understand host–microbiota interactions. Chironomus transvaalensis populations peaked biannually in August and May–June. The composition of the endogenous bacterial communities of their egg masses clustered in two groups according to the sampling periods August–November and May–July. Nevertheless, a core bacterial community (43%) was present in all egg-mass samples. The most abundant phyla were: Proteobacteria, Firmicutes, Cyanobacteria and Bacteroidetes. The abundance of several genera (e.g. Rheinheimera and Pseudomonas) was positively correlated with C. transvaalensis population dynamics, while a predator–prey interaction was observed between the relative abundance of Vibrio OTUs and C. transvaalensis population size. Chironomids are known to tolerate toxic and stress conditions, and our results demonstrated that bacterial genera that may protect the insect under these conditions are present in the egg masses. After hatching, the first larval meal is the gelatinous matrix that surrounds the eggs. This meal contains a probiotic consortium that may protect the larva during its metamorphosis. The results provide important insights into the host–microbe interactions of chironomids.
Investigating the role of ERAD on antibody processing in glycoengineeredSaccharomyces cerevisiae
Authors: Piirainen Mari A , Frey Alexander D 
Published: January 2020

ABSTRACTN-glycosylation plays an important role in the endoplasmic reticulum quality control (ERQC). N-glycan biosynthesis pathways have been engineered in yeasts and fungi to enable the production of therapeutic glycoproteins with human-compatible N-glycosylation, and some glycoengineering approaches alter the synthesis of the lipid-linked oligosaccharide (LLO). Because the effects of LLO engineering on ERQC are currently unknown, we characterized intracellular processing of IgG in glycoengineered Δalg3 Δalg11 Saccharomyces cerevisiae strain and analyzed how altered LLO structures affect endoplasmic reticulum-associated degradation (ERAD). Intracellular IgG light and heavy chain molecules expressed in Δalg3 Δalg11 strain are ERAD substrates and targeted to ERAD independently of Yos9p and Htm1p, whereas in the presence of ALG3 ERAD targeting is dependent on Yos9p but does not require Htm1p. Blocking of ERAD accumulated ER and post-Golgi forms of IgG and increased glycosylation of matα secretion signal but did not improve IgG secretion. Our results show ERAD targeting of a heterologous glycoprotein in yeast, and suggest that proteins in the ER can be targeted to ERAD via other mechanisms than the Htm1p-Yos9p-dependent route when the LLO biosynthesis is altered.
A Longitudinal Study of Retirement Transition and Advance Directive Completion
Authors: Koss Catheryn S 
Published: January 2020

Abstract

Background and Objectives
Advance directives (AD) help to ensure patients’ wishes are honored and contribute to improved end-of-life care. According to normative life course theory, retirement is a significant role change that signals a transition into the third age and its socially prescribed activities. This study tested whether transitioning from work to retirement prompted AD completion.

Research Design and Methods
The sample included Health and Retirement Study participants who, in 2012, had no ADs and were not completely retired (N = 919). Three waves of data were analyzed using multinomial logistic regression to test associations between retirement transition and advance directive completion.

Results
By 2014, 21% had completed ADs and another 17% completed them by 2016. Those who completely retired between 2012 and 2014 were almost twice as likely to complete ADs between 2014 and 2016. Graduated increase in level of retirement between 2012 and 2014 was associated with higher odds of new AD possession in 2016, but did not reach statistical significance at p &lt; .05.

Discussion and Implications
The period following retirement may be an optimal time to encourage patients and clients who have not already done so to complete advance directives.
Noise-based ballistic wave passive seismic monitoring – Part 2: surface waves
Authors: Mordret Aurélien , Courbis Roméo , Brenguier Florent , Chmiel Małgorzata , Garambois Stéphane , Mao Shujuan , Boué Pierre , Campman Xander , Lecocq Thomas , Van der Veen Wim , Hollis Dan 
Published: January 2020

SUMMARYWe develop a new method to monitor and locate seismic velocity changes in the subsurface using seismic noise interferometry. Contrary to most ambient noise monitoring techniques, we use the ballistic Rayleigh waves computed from 30 d records on a dense nodal array located above the Groningen gas field (the Netherlands), instead of their coda waves. We infer the daily relative phase velocity dispersion changes as a function of frequency and propagation distance with a cross-wavelet transform processing. Assuming a 1-D velocity change within the medium, the induced ballistic Rayleigh wave phase shift exhibits a linear trend as a function of the propagation distance. Measuring this trend for the fundamental mode and the first overtone of the Rayleigh waves for frequencies between 0.5 and 1.1 Hz enables us to invert for shear wave daily velocity changes in the first 1.5 km of the subsurface. The observed deep velocity changes (±1.5 per cent) are difficult to interpret given the environmental factors information available. Most of the observed shallow changes seem associated with effective pressure variations. We observe a reduction of shear wave velocity (–0.2 per cent) at the time of a large rain event accompanied by a strong decrease in atmospheric pressure loading, followed by a migration at depth of the velocity decrease. Combined with P-wave velocity changes observations from a companion paper, we interpret the changes as caused by the diffusion of effective pressure variations at depth. As a new method, noise-based ballistic wave passive monitoring could be used on several dynamic (hydro-)geological targets and in particular, it could be used to estimate hydrological parameters such as the hydraulic conductivity and diffusivity.
Did the Flores backarc thrust rupture offshore during the 2018 Lombok earthquake sequence in Indonesia?
Authors: Yang Xiaodong , Singh Satish C , Tripathi Anand 
Published: January 2020

SUMMARYThe Flores thrust forms the west segment (∼450 km) of a very active, ∼E–W striking, ∼800-km-long backarc thrust along the east Sunda Arc. In 2018, a deadly earthquake sequence composed of ~110 M4+ events rattled the Indonesian island of Lombok near the Flores thrust and caused tremendous damage on the island, however what is the nature of rupturing during this earthquake sequence remains unknown. Here, using a total of 2120 km of high-resolution seismic profiles covering ∼300 km of the Flores thrust off Bali, Lombok and Sumbawa, in addition to earthquake data and InSAR measurements, we investigated the active thrusting during this earthquake sequence. Our seismic interpretation and structural mapping show that offshore north of Lombok and Bali, the remarkable Flores thrust is essentially blind, deforming the seabed by folds, not faults. The Lombok earthquakes were all shallow thrust events with depth &lt;40 km and occurred within ∼35 km north of the Rinjani volcano beneath the Lombok Island and its northern extremity. The InSAR measurements suggested that the most of the crustal deformation caused by these earthquakes occurred the north the and northeast of the island. The maximum vertical deformation was ∼36 cm near the northwest margin of the island, caused by the 5th August Mw 6.9 event. These observations combined with the presence of blind thrusts off Lombok suggest that the offshore portion of Flores thrust did not rupture during the 2018 Lombok earthquake sequence; the most coseismic slip must have occurred along a deep-rooted, north-verging basal fault and a range of imbricate thrusts beneath the north of the island, not along the buried thrusts offshore. Despite being blind off Lombok and Bali, the Flores thrust can still pose tsunami threats to the adjacent population centres by rupturing the seafloor during future large earthquakes (M &gt; 7) that occur directly on the offshore blind thrusts, not beneath the island like the Lombok sequence. The proximity of the Rinjani volcano and thrust earthquakes suggests a possible role of volcanic activity (e.g. magmatic fluids and gas migration, stress change induced by pressurized magma chamber) in inducing the Lombok earthquakes.
A rapid four-dimensional resistivity data inversion method using temporal segmentation
Authors: Liu Bin , Pang Yonghao , Mao Deqiang , Wang Jing , Liu Zhengyu , Wang Ning , Liu Shenhua , Zhang Xinxin 
Published: January 2020

SUMMARY4-D electrical resistivity tomography (ERT), an important geophysical method, is widely used to observe dynamic processes within static subsurface structures. However, because data acquisition and inversion consume large amounts of time, rapid changes that occur in the medium during a single acquisition cycle are difficult to detect in a timely manner via 4-D inversion. To address this issue, a scheme is proposed in this paper for restructuring continuously measured data sets and performing GPU-parallelized inversion. In this scheme, multiple reference time points are selected in an acquisition cycle, which allows all of the acquired data to be sequentially utilized in a 4-D inversion. In addition, the response of the 4-D inversion to changes in the medium has been enhanced by increasing the weight of new data being added dynamically to the inversion process. To improve the reliability of the inversion, our scheme uses actively varied time-regularization coefficients, which are adjusted according to the range of the changes in model resistivity; this range is predicted by taking the ratio between the independent inversion of the current data set and historical 4-D inversion model. Numerical simulations and experiments show that this new 4-D inversion method is able to locate and depict rapid changes in medium resistivity with a high level of accuracy.
Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder
Authors: Chen Chun-An , Pal Rituraj , Yin Jiani , Tao Huifang , Amawi Abdallah , Sabo Aniko , Bainbridge Matthew N , Gibbs Richard A , Zoghbi Huda Y , Schaaf Christian P 
Published: January 2020

Abstract
Autism spectrum disorders are associated with some degree of developmental regression in up to 30% of all cases. Rarely, however, is the regression so extreme that a developmentally advanced young child would lose almost all ability to communicate and interact with her surroundings. We applied trio whole exome sequencing to a young woman who experienced extreme developmental regression starting at 2.5 years of age and identified compound heterozygous nonsense mutations in TMPRSS9, which encodes for polyserase-1, a transmembrane serine protease of poorly understood physiological function. Using semiquantitative polymerase chain reaction, we showed that Tmprss9 is expressed in various mouse tissues, including the brain. To study the consequences of TMPRSS9 loss of function on the mammalian brain, we generated a knockout mouse model. Through a battery of behavioral assays, we found that Tmprss9−/− mice showed decreased social interest and social recognition. We observed a borderline recognition memory deficit by novel object recognition in aged Tmprss9−/− female mice, but not in aged Tmprss9−/− male mice or younger adult Tmprss9−/− mice in both sexes. This study provides evidence to suggest that loss of function variants in TMPRSS9 are related to an autism spectrum disorder. However, the identification of more individuals with similar phenotypes and TMPRSS9 loss of function variants is required to establish a robust gene–disease relationship.