bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hierarchies of quantum chemical descriptors induced by statistical analyses of domain occupation number operators
Authors: Acke Guillaume , De Baerdemacker Stijn , Martín Pendás Ángel , Bultinck Patrick 
Published: December 2019

AbstractAs approximations to the wave functions governing quantum chemical systems become more and more complex, it is becoming increasingly important to devise descriptors that help understand the practical results of those approximations by condensing information in insightful ways. Quantum chemical descriptors that are able to capture the statistical signatures of quantum chemical interactions provide such conceptual building blocks. Central to an understanding of these descriptors is the concept of a “domain occupation number operator,” which allows the so‐called “real space” and Hilbert space partitionings to be treated on the same footing. Many of the existing descriptors can be expressed as the (central) densities and density cumulants associated with the domain operators. These densities can be obtained by successive differentiation of generating functions, effectively structuring domain associated densities into hierarchies. Not only do the resulting hierarchies indicate how many of the previously reported descriptors are related, they also show which areas have not yet been explored.This article is categorized under:Electronic Structure Theory > Ab Initio Electronic Structure Methods
Detection of spills related to natural gas production
Authors: Wickline Joseph , Hopkinson Leslie 
Published: December 2019

AbstractAcute spills related to natural gas production are rare but pose a threat to water resources. This work evaluated the use of an event detection system (EDS) to identify spills related to Marcellus Shale development. An EDS was applied to water quality data from natural channels impacted by three known and one simulated spill of various oil and gas byproducts (spill volumes: 7.9–23.8 m3). Events were detected in the week following the spills for two of the known spills, but false alarms reduced confidence in detection. Events detected for the third spill were attributed to sensor malfunction. The simulated spill was not detected. Results highlight the difficulty in identifying acute events and support the need for the development of monitoring strategies.Practitioner points

Event detection systems were utilized to identify spills related to natural gas production.

Spills of production fluid, drilling mud, and flowback fluid were considered.

Spills were not detected using the event detection system, supporting the need for the development of monitoring strategies.
Let’s play on Facebook: using sentiment analysis and social media metrics to measure the success of YouTube gamers’ post types
Authors: Poecze Flora , Ebster Claus , Strauss Christine 
Published: December 2019

AbstractThis paper discusses the analysis results of successful self-marketing techniques on Facebook pages in the cases of three YouTube gamers: PewDiePie, Markiplier, and Kwebbelkop. The research focus was to identify significant differences in terms of the gamers’ user-generated Facebook metrics and commentary sentiments. Analysis of variance (ANOVA) andk-nearest neighbor sentiment analysis were employed as core research methods. ANOVA of the classified post categories revealed that photos tended to show significantly more user-generated interactions than other post types, while, on the other hand, re-posted YouTube videos gained significantly fewer numbers in the retrieved metrics than other content types.K-nearest neighbor sentiment analysis pointed out underlying follower negativity in cases where user-generated activity was relatively low, thereby improving the understanding of the opinion of the masses previously hidden behind metrics such as the number of likes, comments, and shares. The paper at hand highlights the methodological design of the study as well as a detailed discussion of key findings and their implications, and future work. The results per se indicate the need to utilize natural language processing techniques to optimize brand communication on social media and highlight the importance of considering machine learning sentiment analysis techniques for a better understanding of consumer feedback.
Efficacy and safety of migalastat in a Japanese population: a subgroup analysis of the ATTRACT study
Authors: Narita Ichiei , Ohashi Toya , Sakai Norio , Hamazaki Takashi , Skuban Nina , Castelli Jeffrey P. , Lagast Hjalmar , Barth Jay A. 
Published: December 2019

Abstract
Background
Fabry disease is a progressive X-linked lysosomal disorder. In this subgroup analysis of the global phase III ATTRACT study, the efficacy and safety of oral migalastat, a pharmacologic chaperone, were investigated in Japanese patients with Fabry disease.

Methods
Patients were randomly assigned to receive migalastat (150 mg every other day) or to continue biweekly enzyme replacement therapy infusions (ERT; agalsidase alfa 0.2 mg/kg or agalsidase beta 1.0 mg/kg) for 18 months followed by a 12-month open-label extension during which all patients received migalastat. End points included glomerular filtration rate (estimated and measured), left ventricular mass index (LVMi), composite clinical outcomes, leukocyte alpha-galactosidase A activity, plasma globotriaosylsphingosine (lyso-Gb3), and safety.

Results
Data from 7 Japanese patients (migalastat, 5; ERT, 2), mean age 55 years, with high disease burden, were analyzed. All patients in the migalastat group completed the open-label comparison and extension periods. At 18 months, efficacy in the Japanese patient population was similar to that in the overall ATTRACT population. Migalastat treatment increased leukocyte alpha-galactosidase A activity, stabilized renal function, and decreased LVMi. Plasma lyso-Gb3 levels remained low and stable. Additionally, the long-term extension study showed that efficacy of migalastat was maintained for up to 48 months. Migalastat was safe and well tolerated in the Japanese patients, as in the overall ATTRACT population.

Conclusion
Migalastat can be used to treat Japanese patients with Fabry disease with GLA mutations amenable to migalastat according to the dosage and administration approved in other countries.

Trial registration numbers
ClinicalTrials.gov, NCT01218659 and NCT02194985.
Clinical pharmacological study of dotinurad administered to male and female elderly or young subjects
Authors: Nakatani Hiroshi , Fushimi Masahiko , Sasaki Tomomitsu , Okui Daisuke , Ohashi Tetsuo 
Published: December 2019

Abstract
Background
Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of dotinurad were evaluated in healthy subjects.

Methods
An open-label study of a single oral administration of dotinurad 1 mg was conducted in elderly (≥ 65 years) Japanese males and females, and young (20–35 years) males and females (six patients each).

Results
Following a single-dose administration of dotinurad, the change in dotinurad plasma concentration showed a similar profile across groups. Regarding the PK parameters, there was no significant difference between elderly and young subjects. On comparing males and females, significant differences were observed in some parameters in elderly subjects. However, these differences in some parameters could not be detected by adjust for body weight. When PD parameters in elderly and young subjects were compared, significant differences were observed in some parameters in male subjects. On comparing males and females, significant differences were observed in some parameters in young subjects; however, the percent change in serum uric acid concentration decreased over time was relatively close for both groups. There were no clinically relevant safety problems.

Conclusion
Age and gender had no clinically meaningful effect on the PK, PD, and safety of dotinurad.

Clinical trials
ClinicalTrials.gov identifier: NCT02344875.
SEOM clinical guidelines in hereditary breast and ovarian cancer (2019)
Authors:   the SEOM Hereditary Cancer Working Group, González-Santiago S. , Ramón y Cajal T. , Aguirre E. , Alés-Martínez J. E. , Andrés R. , Balmaña J. , Graña B. , Herrero A. , Llort G. , González-del-Alba A. 
Published: December 2019

AbstractMutations inBRCA1andBRCA2high penetrance genes account for most hereditary breast and ovarian cancer, although other new high-moderate penetrance genes included in multigene panels have increased the genetic diagnosis of hereditary breast and ovarian cancer families by 50%. Multigene cancer panels provide new challenges related to increased frequency of variants of uncertain significance, new gene-specific cancer risk assessments, and clinical recommendations for carriers of mutations of new genes. Although clinical criteria for genetic testing continue to be largely based on personal and family history with around a 10% detection rate, broader criteria are being applied with a lower threshold for detecting mutations when there are therapeutic implications for patients with breast or ovarian cancer. In this regard, new models of genetic counselling and testing are being implemented following the registration of PARP inhibitors for individuals who display BRCA mutations. Massive sequencing techniques in tumor tissue is also driving a paradigm shift in genetic testing and potential identification of germline mutations. In this paper, we review the current clinical criteria for genetic testing, as well as surveillance recommendations in healthy carriers, risk reduction surgical options, and new treatment strategies in breast cancer gene-mutated carriers.
Managing large distributed dynamic graphs for smart city network applications
Authors: Voloch Nadav , Voloch - Bloch Noa , Zadok Yair 
Published: December 2019

AbstractSmart cities and traffic applications can be modelled by dynamic graphs for which vertices or edges can be added, removed or change their properties. In the smart city or traffic monitoring problem, we wish to detect if a city dynamic graph maintains a certain local or global property. Monitoring city large dynamic graphs, is even more complicated. To treat the monitoring problem efficiently we divide a large city graph into sub-graphs. In the distributed monitoring problem we would like to define some local conditions for which the global city graph G maintains a certain property. Furthermore, we would like to detect if a local city change in a sub-graph affect a global graph property. Here we show that turning the graph into a non-trivial one by handling directed graphs, weighted graphs, graphs with nodes that contain different attributes or combinations of these aspects, can be integrated in known urban environment applications. These implementations are demonstrated here in two types of network applications: traffic network application and on-line social network smart city applications. We exemplify these two problems, show their experimental results and characterize efficient monitoring algorithms that can handle them.
The time varying network of urban space uses in Milan
Authors: Bernini Alba , Toure Amadou Lamine , Casagrandi Renato 
Published: December 2019

AbstractIn a metropolis, people movements design intricate patterns that change on very short temporal scales. Population mobility obviously is not random, but driven by the land uses of the city. Such an urban ecosystem can interestingly be explored by integrating the spatial analysis of land uses (through ecological indicators commonly used to characterize natural environments) with the temporal analysis of human mobility (reconstructed from anonymized mobile phone data). Considering the city of Milan (Italy) as a case study, here we aimed to identify the complex relations occurring between the land-use composition of its neighborhoods and the spatio-temporal patterns of occupation made by citizens. We generated two spatially explicit networks, one static and the other temporal, based on the analysis of land uses and mobile phone data, respectively. The comparison between the results of community detection performed on both networks revealed that neighborhoods that are similar in terms of land-use composition are not necessarily characterized by analogous temporal fluctuations of human activities. In particular, the historical concentric urban structure of Milan is still under play. Our big data driven approach to characterize urban diversity provides outcomes that could be important (i) to better understand how and when urban spaces are actually used, and (ii) to allow policy makers improving strategic development plans that account for the needs of metropolis-like permanently changing cities.
Access to Information, Higher Education, and Reputational Risk: Insights from a Case Study
Authors: Lamoureux Patrick 
Published: December 2019

AbstractAccess to information and freedom of information (ATI/FOI) requests are an increasingly utilized means of generating data in the social sciences. An impressive multi-disciplinary and international literature has emerged which mobilizes ATI/FOI requests in research on policing, national security, and imprisonment. Absent from this growing literature is work which deploys ATI/FOI requests in research on higher education institutions (HEIs). In this article I examine the use of ATI/FOI requests as a methodological tool for producing data on HEIs. I highlight the data-generating opportunities that this tool offers higher education researchers and provide a first-hand account of how ATI/FOI requests can be mobilized in higher education research. I argue that despite the value of ATI/FOI requests for producing data on academic institutions, the information management practices of HEIs limit the effectiveness of ATI/FOI in ways that I detail drawing on my experience using information requests to scrutinize the quality assurance of undergraduate degree programs in Ontario. I suggest that in an age of rankings and league tables HEIs are likely to prioritize the protection of their reputation over the right of access. In conclusion I consider the implications of the article’s findings for higher education researchers and ATI/FOI users.
The one text in the many: separate and composite readings of an Early Chinese historical manuscript
Authors: Krijgsman Rens , Vogt Paul Nicholas 
Published: December 2019

AbstractThe manuscript carrying the titleZhuangwang ji Cheng莊王既成, from the Shanghai Museum corpus of bamboo slips, bears two related anecdotes concerning the early Chinese monarch King Zhuang of Chu. In this article, we translate both stories and offer interpretations of them both as individual texts and as a composite narrative, situating both readings in a context of intertextual references based on shared cultural memory. Approaching the anecdotes together, we argue, generates an additional layer of meaning, yielding both a deep sense of dramatic irony and a critique of the value of foreknowledge – and, by extension, of the explanatory value of historiography. In detailing how this layer of meaning is generated, we explore the range of reading experiences and approaches to understanding the past enabled by combining separate but related textual units, a prevalent mode of composition and consumption in the manuscript culture of Warring States China.
OP28 Patient Involvement at AQuAS: Experiences And Reflections For Future
Authors: Masana Lina , Garcia Emmanuel Gimenez , Espallargues Mireia 
Published: December 2019

IntroductionAQuAS is gradually incorporating patient involvement in health technology assessment (HTA). We present two experiences conducted during 2018 and the different methods and approaches used. The aim is to reflect on learnings from those experiences to improve ways for increasing patient involvement with HTA at AQuAS.MethodsWe conducted two experiences using different quantitative and qualitative techniques (mix-methods approach). The first, a focus group discussion regarding the use of 3D-technologies for maxillofacial reconstruction with a selection of hospital patients that received maxillofacial reconstruction, which included the use of a quality-of-life retrospective self-assessment tool. The second, a sequence of email correspondence regarding cataract surgery technology (femtosecond laser-assisted cataract surgery (FLACS), in the context of an EUnetHTA Joint Assessment) with a patients’ association representative, to learn their opinion regarding the use of laser technology.ResultsMain learnings were: (1) patients and associations have different levels of knowledge and expertise to consider when planning an HTA; (2) sharing experience and knowledge among peers (i.e. focus group) proved to have a positive impact on patients and worked as a resource for some to improve knowledge on their condition; (3) critiques were received regarding a specific Patient Reported Experience template for HTA patient involvement (iv) quality of life retrospective self-assessment tool provided unexpected positive and negative results.ConclusionsRecent patient involvement in HTA at AQuAS proved to be useful to complement HTA reports. We believe that patients’ experiences and opinions can help decision-making regarding the use, disinvestment or incorporation of health technologies, contribute to the improvement of tools and survey accuracy and improve doctor-patient communication. Their involvement might be beneficial for them to gain more knowledge, share experiences, reflect on their health situation and improve communication with the professionals that treat them. Future patient-involvement in HTA is needed, e.g. considering the social perspective in economic evaluations or including patients in recommendation consensus panels.
OP38 Implementing Social Innovations: From Evidence-Based To Theory-Driven
Authors: Zechmeister-Koss Ingrid , Goodyear Melinda , Paul Jean , Bauer Annette 
Published: December 2019

IntroductionFor the last decades, health technology assessment has been strongly promoted in order to provide evidence-based rather than eminence-based healthcare. However, when it comes to implementing interventions that are based on processes and behavior rather than products, importing evidence-based interventions is likely to fail because it ignores the strong influence of contextual factors. In a recently started research project, an alternative approach is tested.MethodsThe project aims at improving identification and support of children who have parents with a mental illness in an Austrian region (Tyrol). A theory- and stakeholder-driven approach has been designed in order to co-develop, implement and evaluate practice approaches for improving the situation for children. The former addresses the questions whether, how and why suggested practices may work and the later brings together evidence and practice to develop interventions that are feasible and take the regional context and service settings into account.ResultsBased on evidence from various sources (literature, international and local stakeholder interviews), theories that describe the key mechanisms of action to influence outcomes for children have been developed. A regional and interdisciplinary group of practitioners and people with lived experience has been established to facilitate the development of the theory of change and practice approaches for the region and local service settings. The final practice model is then monitored in the respective organizations with implementation support from the research team.ConclusionsTheory-driven and co-designed-based approaches are a feasible alternative to ‘off-the-shelf’ evidence-based practices for supporting decision makers in implementing complex interventions. However, they require a broad variety of skills within the research team as well as willingness to accept uncertainties of the final outcomes produced, which can also be of risk to funders. The ongoing project will demonstrate whether the developed practices will be implemented successfully and result in benefits for the affected children.
OP39 Adapting HTA To Suit Emerging Needs - An Australian Experience
Authors: Warner Mary 
Published: December 2019

IntroductionAustralia has a well-developed HTA system for approving, funding and disinvesting in medical services, but how does it cope when it assesses new or existing services when health system frameworks, policy and legislation do not keep pace? This presentation will present a number of case studies where HTA methods have adapted to suit emerging health needs of the Australian community.MethodsAustralia's HTA system has been adapted over recent years to allow it to perform HTA on novel services that do not fit into its standard HTA pathway to public funding. There has also been an increasing number of assessments where HTA has been unusually sponsored by the funder to assess priority health care needs.ResultsMore Medicare funding for addiction and sexual health consultation services are an example of a novel HTA which led to more public funding for these services. Limited evidence for these services was available and there was difficulty in demonstrating that increased public funding would lead to better outcomes for patients. A range of techniques, such as examining real world data and stakeholder views were partnered with HTA to assess these services. Currently, HTA is being utilised to assess a novel medical treatment known as the anti-CD19 chimeric antigen receptor T cell (CAR-T) therapeutic process. This is a complex, non-standard HTA which encompasses aspects of the Australian hospital funding system, Medicare and the Pharmaceutical Benefits Scheme and requires an adapted HTA process to assess evidence across a range of funder systems.ConclusionsAustralia's well established HTA system has adapted to become more agile to suit emerging health care needs for a range of interest groups, the government, sponsors and consumers. Consultation with stakeholders and the community have assisted in developing and refining these new processes.