bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory medium and circulatory anatomy constrain size evolution in marine macrofauna
Authors: Heim Noel A. , Bakshi Saket H. , Buu Loc , Chen Stephanie , Heh Shannon , Jain Ashli , Noll Christopher , Patkar Ameya , Rizk Noah , Sundararajan Sriram , Villante Isabella , Knope Matthew L. , Payne Jonathan L. 
Published: May 2020

AbstractThe typical marine animal has increased in biovolume by more than two orders of magnitude since the beginning of the Cambrian, but the causes of this trend remain unknown. We test the hypothesis that the efficiency of intra-organism oxygen delivery is a major constraint on body-size evolution in marine animals. To test this hypothesis, we compiled a dataset comprising 13,723 marine animal genera spanning the Phanerozoic. We coded each genus according to its respiratory medium, circulatory anatomy, and feeding mode. In extant genera, we find that respiratory medium and circulatory anatomy explain more of the difference in size than feeding modes. Likewise, we find that most of the Phanerozoic increase in mean biovolume is accounted for by size increase in taxa that accomplish oxygen delivery through closed circulatory systems. During the Cambrian, water-breathing animals with closed circulatory systems were smaller, on average, than contemporaries with open circulatory systems. However, genera with closed circulatory systems superseded in size genera with open circulatory systems by the Middle Ordovician, as part of their Phanerozoic-long trend of increasing size. In a regression analysis, respiratory and circulatory anatomy explain far more size variation in the living fauna than do feeding modes, even after accounting for taxonomic affinity at the class level. These findings suggest that ecological and environmental drivers of the Phanerozoic increase in the mean size of marine animals operated within strong, anatomically determined constraints.
Option-Based Estimation of the Price of Coskewness and Cokurtosis Risk
Authors: Christoffersen Peter , Fournier Mathieu , Jacobs Kris , Karoui Mehdi 
Published: May 2020

AbstractWe show that the prices of risk for factors that are nonlinear in the market return can be obtained using index option prices. The price of coskewness risk corresponds to the market variance risk premium, and the price of cokurtosis risk corresponds to the market skewness risk premium. Option-based estimates of the prices of risk lead to reasonable values of the associated risk premia. An analysis of factor models with coskewness risk indicates that the new estimates of the price of risk improve the models’ performance compared with regression-based estimates.
Second language learning of phonological alternations with and without orthographic input: Evidence from the acquisition of a German-like voicing alternation
Authors: Barrios Shannon L. , Hayes-Harb Rachel 
Published: May 2020

AbstractWhile a growing body of research investigates the influence of orthographic input on the acquisition of second language (L2) segmental contrasts, few studies have examined its influence on the acquisition of L2 phonological processes. Hayes-Harb, Brown, and Smith (2018) showed that exposure to words’ written forms caused native English speakers to misremember the voicing of final obstruents in German-like words exemplifying voicing neutralization. However, they did not examine participants’ acquisition of the final devoicing process. To address this gap, we conducted two experiments wherein native English speakers (assigned to Orthography or No Orthography groups) learned German-like words in suffixed and unsuffixed forms, and later completed a picture naming test. Experiment 1 investigated learners’ knowledge of the surface voicing of obstruents in both final and nonfinal position, and revealed that while all participants produced underlyingly voiced obstruents as voiceless more often in final than nonfinal position, the difference was only significant for No Orthography participants. Experiment 2 investigated participants’ ability to apply the devoicing process to new words, and provided no evidence of generalization. Together these findings shed light on the acquisition of final devoicing by naïve adult learners, as well as the influence of orthographic input in the acquisition of a phonological alternation.
Tipo de antipsicótico y correlatos de la interrupción del tratamiento de antipsicóticos en el tratamiento ambulatorio de la esquizofrenia
Authors: María Haro Joseph , Novick Diego , Belger Mark , Jones Peter B. ,   Junta Consultiva SOHO
Published: May 2020

ResumenSe analizó el mantenimiento de la medicación antipsicótica y los factores que influyen en él utilizando datos del estudio SOHO, un gran estudio observacional de la evolucion del tratamiento de antipsicóticos para la esquizofrenia en Europa. Se analizó a un total de 7.186 pacientes adultos en el entorno ambulatorio en los que se inició o cambió la medicación antipsicótica y a quienes se prescribió sólo un antipsicótico después de la vísita de linea de base. El mantenimiento de la medicación a los 12 meses variaba con el tipo de antipsicótico prescrito, siendo más alto con la clozapina (79,5%) y la olanzapina (77%) y más bajo con la quetiapina (51,4%) y la amisulprida (58,2%). El análisis de regresión logística mύltiple demostró que el tipo de antipsicótico prescrito en la línea de base era el predictor más importante del mantenimiento de la medicación. La dependencia de alcohol, el consumo de estabilizadores del estado de ánimo, el ingreso obligatorio o la detención en los 6 meses anteriores, la mayor gravedad clínica y el cambio de la medicación antipsicótica debido a falta de eficacia en la línea de base predecían una frecuencia mayor de interrupción de la medicación en los 12 meses posteriores. Por contraste, el mantenimiento de la medicación era más alto entre los pacientes que no habían recibido ningύn tratamiento en la línea de base, eran activos socialmente o habían perdido la líbido en la linea de base. Los hallazgos de este estudio se deben interpretar conservadoramente a causa de su diseño observacional no distribuido al azar. © 2005 Elsevier SAS. Todos los derechos reservados.
Spatial Distribution of Heterochromatin Bodies in the Nuclei of Triatoma infestans (Klug)
Authors: Imperador Carlos Henrique L. , Bardella Vanessa B. , dos Anjos Eli Heber M. , Rodrigues Vera L.C.C. , Cabral-de-Mello Diogo C. , Mello Maria Luiza S. 
Published: May 2020

AbstractConstitutive heterochromatin typically exhibits low gene density and is commonly found adjacent or close to the nuclear periphery, in contrast to transcriptionally active genes concentrated in the innermost nuclear region. In Triatoma infestans cells, conspicuous constitutive heterochromatin forms deeply stained structures named chromocenters. However, to the best of our knowledge, no information exists regarding whether these chromocenters acquire a precise topology in the cell nuclei or whether their 18S rDNA, which is important for ribosome function, faces the nuclear center preferentially. In this work, the spatial distribution of fluorescent Feulgen-stained chromocenters and the distribution of their 18S rDNA was analyzed in Malpighian tubule cells of T. infestans using confocal microscopy. The chromocenters were shown to be spatially positioned relatively close to the nuclear periphery, though not adjacent to it. The variable distance between the chromocenters and the nuclear periphery suggests mobility of these bodies within the cell nuclei. The distribution of 18S rDNA at the edge of the chromocenters was not found to face the nuclear interior exclusively. Because the genome regions containing 18S rDNA in the chromocenters also face the nuclear periphery, the proximity of the chromocenters to this nuclear region is not assumed to be associated with overall gene silencing.
Microanalysis of Fish Ovarian Follicular Atresia: A Possible Synergic Action of Somatic and Immune Cells
Authors: Mokhtar Doaa M. , Hussein Marwa M. 
Published: May 2020

AbstractThe present study describes in detail the morphological characteristics of the process of ovarian follicular atresia in Redbelly tilapia (Coptodon zillii) during the nonbreeding season using light and electron microscopy and immunohistochemistry. The follicular regression process was initiated with shrinkage and disintegration of the nuclear membrane of oocytes resulting in dispersing of chromatin within the ooplasm, followed by marked hyperplasia and hypertrophy of follicular and granulosa cells, which exhibited a strong phagocytic activity to engulf the liquefied yolk particles. Rodlet cells and granulocytes were recorded on the follicular wall and invaded the regressed follicles. Rodlet cells expressed a strong immunoreactivity to matrix metalloperoxidase (MMP-9) and α-smooth muscle actin, while neutrophils expressed a strong reactivity to Myeloperoxidase-3 (MPO). In the advanced stage of follicular atresia, the yolk was almost phagocytized and resorbed and the regressed follicle lost its integrity and appeared to be formed of a cellular mass of phagocytic cells. Transmission electron microscopy revealed the presence of neutrophils, eosinophils, and dendritic cells within the atretic follicle in between these phagocytic cells. Moreover, numerous lysosomes, granules, and phagosomes were observed within the cytoplasm of both phagocytic cells and granulocytes. Telocytes were also demonstrated within the highly thickened richly vascularized theca layer during the late stages of follicular atresia. Immunohistochemical staining for caspase-3 established the participation of apoptosis in the advanced stages of follicular regression. Immune cells, rodlet cells, and telocytes in combination with follicular cells play an essential role in follicular atresia. In conclusion, the present study provides a new evidence on the role of both somatic and immune cells in the phenomenon of ovarian follicular atresia in Redbelly tilapia (Coptodon zillii) during the nonbreeding season.
Making visible, rendering obscure: reading the plastic crisis through contemporary artistic visual representations
Authors: Chertkovskaya Ekaterina , Holmberg Karl , Petersén Moa , Stripple Johannes , Ullström Sara 
Published: May 2020

Non-technical summaryModern society without plastics is difficult to imagine. Yet the global plastic system is linked to a multitude of problems of a scope that is hard to grasp and address. In short, we are facing a plastic crisis. This article explores the role of art in stimulating critical reflection about plastics and analyses how it contributes to making the plastic crisis increasingly visible. Plastic-related artworks mostly focus on ocean pollution and do not pay due attention to other aspects of the plastic crisis. At the same time, they creatively communicate clear and emotionally charged messages. Art has the potential to play an important role in coming to grips with the plastic crisis if it succeeds in adopting a broader understanding of the problem.
Ameliorating soil acidity–reduced growth of rigid ryegrass (Lolium rigidum) in wheat
Authors: Borger Catherine P. D. , Azam Gaus , Gazey Chris , van Burgel Andrew , Scanlan Craig A. 
Published: May 2020

AbstractEstimates indicate that 30% of land surface globally is affected by soil acidity, influencing agricultural production. Application of lime increases soil pH and improves crop growth. We tested the hypothesis that liming will reduce rigid ryegrass (Lolium rigidum Gaudin) growth by improving the competitive ability of the crop. Experiments at Merredin and Wongan Hills in Western Australia indicated that application of lime in previous years reduced L. rigidum density, biomass, and seed production in wheat (Triticum aestivum L.) crops in 2018. At Merredin, L. rigidum seed production in 2018 was reduced from 9,390 to 2,820 seeds m−2, and wheat tiller number and yield was increased, following lime application of 0 to 6,000 kg ha−1 in 2016. At Wongan Hills, lime application of 4,000 kg ha−1 in 1994 reduced seed production in the 2018 wheat crop from 4,708 to 1,610 seeds m−2, and application of 3,000 kg ha−1 of lime in 2014 reduced seed production from 3,959 to 921 seeds m−2 in 2018. Again, lime increased wheat tiller number, but not yield. A screen house experiment (in controlled conditions) indicated that lime application increased the initial growth of both L. rigidum and wheat seedlings. This supports the conclusion that reduced L. rigidum growth and seed production in the field resulted from increased competitive ability of the crop, rather than any direct and detrimental impact of lime on L. rigidum growth. Incorporation of lime reduced initial emergence of L. rigidum in controlled conditions, with L. rigidum seeds at a uniform depth, and in the field experiments in situations of high weed density, with seeds buried by the incorporation process. Nationally, the revenue loss from residual L. rigidum in crop is A$93 million per year. The current research confirms that application of lime will increase the competitive ability of crops growing in regions with acidic soils.
Glufosinate enhances the activity of protoporphyrinogen oxidase inhibitors
Authors: Takano Hudson K , Beffa Roland , Preston Christopher , Westra Philip , Dayan Franck E 
Published: May 2020

AbstractGlufosinate inhibits glutamine synthetase (GS), a key enzyme for amino acid metabolism and photorespiration. Protoporphyrinogen oxidase (PPO) inhibitors block chlorophyll biosynthesis and cause protoporphyrin accumulation, a highly photodynamic intermediate. Both herbicides ultimately lead to plant death by a massive accumulation of reactive oxygen species (ROS) through different mechanisms. We investigated a potential synergistic effect by the mixture of the two herbicide mechanisms of action (MoAs). The tank mix between a low rate of glufosinate (280 g ai ha−1) with an ultra-low dose of saflufenacil (1 g ha−1) provided enhanced herbicidal activity compared with the products applied individually on Palmer amaranth (Amaranthus palmeriS. Watson). The synergism between the two herbicides was also confirmed by isobole analysis and field trials. The herbicide combination provided high levels of efficacy when applied at low temperature and low humidity. Mechanistically, glufosinate caused a transient accumulation of glutamate, the building block for chlorophyll biosynthesis. Consequently, inhibition of both GS and PPO resulted in greater accumulation of protoporphyrin and ROS, forming the physiological basis for the synergism between glufosinate and PPO inhibitors. While the synergy between the two herbicide MoAs provided excellent efficacy on weeds, it caused low injury to PPO-resistant waterhemp [Amaranthus tuberculatus(Moq.) Sauer] and high injury to both glufosinate-resistant and glufosinate-susceptible soybean [Glycine max(L.) Merr.]. Glufosinate enhances the activity of PPO inhibitors through glutamate and protoporphyrin accumulation, leading to increased levels of ROS and lipid peroxidation. The synergism between the two herbicide MoAs can help to overcome environmental effects limiting the efficacy of glufosinate. Future research is needed to optimize the uses for this herbicidal composition across different cropping systems.
How Thermochemical Piles Can (Periodically) Generate Plumes at Their Edges
Authors: Heyn Björn H. , Conrad Clinton P. , Trønnes Reidar G. 
Published: May 2020

AbstractDeep‐rooted mantle plumes are thought to originate from the margins of the Large Low Shear Velocity Provinces (LLSVPs) at the base of the mantle. Visible in seismic tomography, the LLSVPs are usually interpreted to be intrinsically dense thermochemical piles in numerical models. Although piles deflect lateral mantle flow upward at their edges, the mechanism for localized plume formation is still not well understood. In this study, we develop numerical models that show plumes rising from the margin of a dense thermochemical pile, temporarily increasing its local thickness until material at the pile top cools and the pile starts to collapse back toward the core‐mantle boundary (CMB). This causes dense pile material to spread laterally along the CMB, locally thickening the lower thermal boundary layer on the CMB next to the pile, and initiating a new plume. The resulting plume cycle is reflected in both the thickness and lateral motion of the local pile margin within a few hundred km of the pile edge, while the overall thickness of the pile is not affected. The period of plume generation is mainly controlled by the rate at which slab material is transported to the CMB, and thus depends on the plate velocity and the sinking rate of slabs in the lower mantle. A pile collapse, with plumes forming along the edges of the pile's radially extending corner, may, for example, explain the observed clustering of Large Igneous Provinces (LIPs) in the southeastern corner of the African LLSVP around 95–155 Ma.
A Granular Physics‐Based View of Fault Friction Experiments
Authors: Ferdowsi Behrooz , Rubin Allan M. 
Published: May 2020

AbstractRate‐ and state‐dependent friction (RSF) equations are commonly used to describe the time‐dependent frictional response of fault gouge to perturbations in sliding velocity. Among the better‐known versions are the Aging and Slip laws for the evolution of state. Although the Slip law is more successful, neither can predict all the robust features of lab data. RSF laws are also empirical, and their micromechanical origin is a matter of much debate. Here we use a granular physics‐based model to explore the extent to which RSF behavior, as observed in rock and gouge friction experiments, can be explained by the response of a granular gouge layer with time‐independent properties at the contact scale. We examine slip histories for which abundant lab data are available and find that the granular model (1) mimics the Slip law for those loading protocols where the Slip law accurately models laboratory data (velocity‐step and slide‐hold tests) and (2) deviates from the Slip law under conditions where the Slip law fails to match laboratory data (the reslide portions of slide‐hold‐slide tests), in the proper sense to better match those data. The simulations also indicate that state is sometimes decoupled from porosity in a way that is inconsistent with traditional interpretations of “state” in RSF. Finally, if the “granular temperature” of the gouge is suitably normalized by the confining pressure, it produces an estimate of the direct velocity effect (the RSF parameter a) that is consistent with our simulations and in the ballpark of lab data.
Near‐Future pCO2 During the Hot Miocene Climatic Optimum
Authors: Steinthorsdottir M. , Jardine P. E. , Rember W. C. 
Published: May 2020

AbstractTo improve future predictions of anthropogenic climate change, a better understanding of the relationship between global temperature and atmospheric concentrations of CO2 (pCO2), or climate sensitivity, is urgently required. Analyzing proxy data from climate change episodes in the past is necessary to achieve this goal, with certain geologic periods, such as the Miocene climatic optimum (MCO), a transient period of global warming with global temperatures up to ~7°C higher than today, increasingly viewed as good analogues to future climate under present emission scenarios. However, a problem remains that climate models cannot reproduce MCO temperatures with less than ~800 ppm pCO2, while most previously published proxies record pCO2 < 450 ppm. Here, we reconstructed MCO pCO2 with a multitaxon fossil leaf database from the well‐dated MCO Lagerstätte deposits of Clarkia, Idaho, USA, using four current methods of pCO2 reconstructions. The methods are principally based on either stomatal densities, carbon isotopes, or a combination of both—thus offering independent results. The total of six reconstructions mostly record pCO2 of ~450–550 ppm. Although slightly higher than previously reconstructed pCO2, the discrepancy with the ~800 ppm required by climate models remains. We conclude that climate sensitivity was heightened during MCO, indicating that highly elevated temperatures can occur at relatively moderate pCO2. Ever higher climate sensitivity with rising temperatures should be very seriously considered in future predictions of climate change.
SOX9 interacts with FOXC1 to activate MYC and regulate CDK7 inhibitor sensitivity in triple-negative breast cancer
Authors: Tang Lin , Jin Juan , Xu Kun , Wang Xin , Tang Jinhai , Guan Xiaoxiang 
Published: May 2020

AbstractTriple-negative breast cancer (TNBC) is particularly sensitive to cyclin-dependent kinase 7 inhibitor, THZ1, compared to hormone receptor (HR)+ breast cancer, but our data found that different TNBC cell lines had a wide range of IC50 values of THZ1, suggesting a possible heterogeneity in sensitivity to THZ1 in TNBC. To seek potential biomarkers of THZ1 sensitivity, we re-analyzed the mRNAs profile in breast cancer cells treated with THZ1 from the previous study and demonstrated that elevated expression of SOX9 was significantly associated with the sensitivity of THZ1 in TNBC. We also verified that SOX9 expression promoted cell proliferation, migration, stemness, and predicted poor prognosis. Moreover, based on the tissue array of 278 patients and over 900 samples from TCGA data, we found that SOX9 expression was significantly higher in TNBC than HR+ breast cancers. Furthermore, ChIP-sequencing indicated that SOX9 binding to enhancer near transcription factor FOXC1, was remarkably inhibited by THZ1. And we also demonstrated that SOX9 and FOXC1 interacted with each other, which might co-operate and co-regulate the MYC signaling pathway in TNBC. Mechanistically, SOX9 may sensitize TNBC cells to THZ1, in a FOXC1-related manner, suggesting that SOX9 could be as a predictive factor of THZ1.
Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations
Authors: Reay William R. , Cairns Murray J. 
Published: May 2020

AbstractThe complex aetiology of schizophrenia is postulated to share components with other psychiatric disorders. We investigated pleiotropy amongst the common variant genomics of schizophrenia and seven other psychiatric disorders using a multimarker association test. Transcriptomic imputation was then leveraged to investigate the functional significance of variation mapped to these genes, prioritising several interesting functional candidates. Gene-based analysis of common variation revealed 67 schizophrenia-associated genes shared with other psychiatric phenotypes, including bipolar disorder, major depressive disorder, ADHD and autism-spectrum disorder. In addition, we uncovered 78 genes significantly enriched with common variant associations for schizophrenia that were not linked to any of these seven disorders (P > 0.05). Multivariable gene-set association suggested that common variation enrichment within biologically constrained genes observed for schizophrenia also occurs across several psychiatric phenotypes. Pairwise meta-analysis of schizophrenia and each psychiatric phenotype was implemented and identified 330 significantly associated genes (PMeta < 2.7 × 10−6) that were only nominally associated with each disorder individually (P < 0.05). These analyses consolidate the overlap between the genomic architecture of schizophrenia and other psychiatric disorders, uncovering several candidate pleiotropic genes which warrant further investigation.