bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory estimation and position correction for hopping robot navigation using monocular camera
Authors: Kovacs Gabor , Kunii Yasuharu , Maeda Takao , Hashimoto Hideki 
Published: June 2020

AbstractIn this paper, a navigation and environment mapping method is presented for small exploration robots that use hopping motion. While previous research about hopping rovers mostly focuses on mobility and mechanical design, the motivation for the proposed method is to provide a fully autonomous navigation system using only a monocular camera. The method accurately estimates the hopping distance and reconstruct the 3D environment using Structure from Motion, proving that a monocular system is not only feasible, but accurate and robust at the same time. The relative scale problem of the reconstructed scene and trajectory is solved by the known gravity and parabolic motion constraints. After each hop, the error in landing position is corrected by a modified Iterative Closest Point algorithm with non-overlapping part elimination. The environmental point cloud is projected onto a 2D image, that is used to find the most suitable landing position for the next hop using protrusion based obstacle detection, and navigate the robot towards the goal direction. Both virtual environment simulations and real experiments confirm the feasibility and highlight the advantages of the presented method.
A modified surgical approach for hard and soft tissue reconstruction of severe periimplantitis defects: laser-assisted periimplant defect regeneration (LAPIDER)
Authors: Noelken Robert , Al-Nawas Bilal 
Published: June 2020

AbstractBackgroundThe main problem in periimplantitis is often the combination of severe periimplant bone loss with a contaminated implant surface and an insufficient soft tissue situation. Classic surgical concepts with crestal access to the bony defect and debridement of the surface most often lead to partial defect regeneration and a soft tissue recession. An incision directly above the pathologic bony lesion is contrary to general surgical treatment rules.AimTo overcome this problem, a new surgical concept was developed which allows to clean the implant surface, reconstruct the bony defect, and improve soft tissue height and thickness without cutting the papilla complex. This publication presents the innovative regenerative treatment approach for severe periimplantitis defects.Material and methodsAfter diagnosis and non-surgical pre-treatment of a severe periimplantitis lesion, the following treatment protocol was applied: horizontal mucosal incision 5 mm apical to marginal mucosa, supraperiosteal preparation in apical direction, cutting through periosteum at the level of the implant apex, subperiosteal coronal flap elevation, exploration and cleaning of the periimplant defect, thorough debridement of the implant surface with the Er:YAG laser, subperiosteal grafting with connective tissue, grafting of the bony defect with autogenous bone chips from the mandibular ramus, and bilayered suturing of periosteum and mucosa. Implant survival, marginal bone levels, periimplant probing depths, recession, and facial mucosa thickness (PIROP ultrasonic measurement) were evaluated in a pilot case at 1-year follow-up examination.ResultsInter-proximal, oral, and buccal marginal bone levels increased significantly to the level of the implant shoulder from pre-operative to 1-year follow-up examination. No signs of suppuration or periimplant infection were present. Probing depths and recession decreased significantly, while the facial mucosa thickness improved from pre-operative to final examination.ConclusionsMarginal bone levels and soft tissue improvement suggest feasibility for the regeneration of severe periimplant hard and soft tissue deficiencies by this new treatment approach. With the use of this concept, the simultaneous implant surface cleansing and improvement of hard and soft tissue seem to be possible and unfavorable postoperative exposition of titanium surface might be prevented. Comparative studies are planned to quantify the effects of this new surgical protocol.
Patient perceived barriers to exercise and their clinical associations in difficult asthma
Authors: Freeman Anna T. , Hill David , Newell Colin , Moyses Helen , Azim Adnan , Knight Deborah , Presland Laura , Harvey Matthew , Haitchi Hans Michael , Watson Alastair , Staples Karl J. , Kurukulaaratchy Ramesh J. , Wilkinson Tom M. A. 
Published: June 2020

Abstract
Background
Exercise is recommended in guidelines for asthma management and has beneficial effects on symptom control, inflammation and lung function in patients with sub-optimally controlled asthma. Despite this, physical activity levels in patients with difficult asthma are often impaired. Understanding the barriers to exercise in people with difficult asthma is crucial for increasing their activity, and in implementing successful, disease modifying, and holistic approaches to improve their health.

Methods
62 Patients within the WATCH Difficult Asthma Cohort (Southampton, UK) completed an Exercise Therapy Burden Questionnaire (ETBQ). The results were analyzed with contemporaneous asthma-related data to determine relationships between perceived exercise barriers and asthma and comorbidity characteristics

Results
Patients were reflective of a difficult asthma cohort, 66% were female, and 63% were atopic. They had a high BMI (median [inter-quartile range]) of 29.3 [25.5–36.2], age of 53.5 [38.75, 65.25], impaired spirometry with FEV1 73% predicted [59.5, 86.6%] and FEV/FVC ratio of 72 [56.5, 78.0] and poor symptom control, as defined by an Asthma Control Questionnaire (ACQ6) result of 2.4 [1.28, 3.2]. A high perceived barriers to exercise score was significantly correlated with increased asthma symptoms (r = 0.452, p < 0.0001), anxiety (r = 0.375, p = 0.005) and depression (r = 0.363, p = 0.008), poor quality of life (r = 0.345, p = 0.015) and number of rescue oral steroid courses in the past 12 months (r = 0.257, p = 0.048). Lung function, blood eosinophil count, FeNO, Njimegen and SNOT22 scores, BMI and hospitalisations in the previous year were not related to exercise perceptions.

Conclusion
In difficult asthma, perceived barriers to exercise are related to symptom burden and psychological morbidity. Therefore, exercise interventions combined with psychological input such as CBT to restructure thought processes around these perceived barriers may be useful in facilitating adoption of exercise.
Recent advances in polymeric drug delivery systems
Authors: Sung Yong Kiel , Kim Sung Wan 
Published: June 2020

Abstract
Background
Polymeric drug delivery systems have been achieved great development in the last two decades. Polymeric drug delivery has defined as a formulation or a device that enables the introduction of a therapeutic substance into the body. Biodegradable and bio-reducible polymers make the magic possible choice for lot of new drug delivery systems. The future prospects of the research for practical applications has required for the development in the field.

Main body
Natural polymers such as arginine, chitosan, dextrin, polysaccharides, poly (glycolic acid), poly (lactic acid), and hyaluronic acid have been treated for polymeric drug delivery systems. Synthetic polymers such as poly (2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide)s, poly(ethylenimine)s, dendritic polymers, biodegradable and bio-absorbable polymers have been also discussed for polymeric drug delivery. Targeting polymeric drug delivery, biomimetic and bio-related polymeric systems, and drug-free macromolecular therapeutics have also treated for polymeric drug delivery. In polymeric gene delivery systems, virial vectors and non-virial vectors for gene delivery have briefly analyzed. The systems of non-virial vectors for gene delivery are polyethylenimine derivatives, polyethylenimine copolymers, and polyethylenimine conjugated bio-reducible polymers, and the systems of virial vectors are DNA conjugates and RNA conjugates for gene delivery.

Conclusion
The development of polymeric drug delivery systems that have based on natural and synthetic polymers are rapidly emerging to pharmaceutical fields. The fruitful progresses have made in the application of biocompatible and bio-related copolymers and dendrimers to cancer treatment, including their use as delivery systems for potent anticancer drugs. Combining perspectives from the synthetic and biological fields will provide a new paradigm for the design of polymeric drug and gene delivery systems.
The effect of tranexamic acid in patients with TBI: a systematic review and meta-analysis of randomized controlled trials
Authors: Du Chao-nan , Liu Bo-xue , Ma Qing-fang , Yang Ming-fei 
Published: June 2020

AbstractTo conduct a systematic review and meta-analysis and evaluate the effect of tranexamic acid in patients with traumatic brain injury. PubMed, EMBASE, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched to identify randomized controlled trials and evaluate the effect of tranexamic acid in traumatic brain injury patients. The primary outcome was mortality. Two reviewers extracted the data independently. The random effect meta-analysis was used to estimate the aggregate effect size of 95% confidence intervals. Six randomized controlled trials investigating tranexamic acid versus placebo and 30073 patients were included. Compared with placebo, tranexamic acid decreased the mortality (RR = 0.92; 95% CI, 0.87–0.96; p < 0.001) and growth of hemorrhagic mass (RR = 0.78; 95% CI, 0.61–0.99; p = 0.04). However, tranexamic acid could not decrease disability or independent, neurosurgery, vascular embolism, and stroke. Current evidence suggested that compared with placebo, tranexamic acid could reduce mortality and growth of hemorrhagic mass. This finding indicated that patients with traumatic brain injury should be treated with tranexamic acid.
Gesture during math instruction specifically benefits learners with high visuospatial working memory capacity
Authors: Aldugom Mary , Fenn Kimberly , Cook Susan Wagner 
Published: June 2020

AbstractBackgroundCharacteristics of both teachers and learners influence mathematical learning. For example, when teachers use hand gestures to support instruction, students learn more than others who learn the same concept with only speech, and students with higher working memory capacity (WMC) learn more rapidly than those with lower WMC. One hypothesis for the effect of gesture on math learning is that gestures provide a signal to learners that can reduce demand on working memory resources during learning. However, it is not known what sort of working memory resources support learning with gesture. Gestures are motoric; they co-occur with verbal language and they are perceived visually.MethodsIn two studies, we investigated the relationship between mathematical learning with or without gesture and individual variation in verbal, visuospatial, and kinesthetic WMC. Students observed a videotaped lesson in a novel mathematical system that either included instruction with both speech and gesture (Study 1) or instruction with only speech (Study 2). After instruction, students solved novel problems in the instructed system and transfer problems in a related system. Finally, students completed verbal, visuospatial, and kinesthetic working memory assessments.ResultsThere was a positive relationship between visuospatial WMC and math learning when gesture was present, but no relationship between visuospatial WMC and math learning when gesture was absent. Rather, when gesture was absent, there was a relationship between verbal WMC and math learning.ConclusionProviding gesture during instruction appears to change the cognitive resources recruited when learning a novel math task.
Effect of prey density of meloidogyne incognita on the predation efficiency of the predator, fictor composticola (nematoda: diplogasteridae)
Authors: Sidhu Harjot Singh , Kanwar Rambir Singh 
Published: June 2020

AbstractPredatory nematodes are important as they fed upon several prey nematode species. The diplogasterid predators are characterized by distinguished alterations in feeding apparatus. The diplogasterid predator, Fictor composticola, feeds on different categories of nematodes like microbivorous, mycophagous, and plant-parasitic nematodes. This study was undertaken under in-vitro conditions, in 1% water-agar plates, and in pots under screen house. In lab. study, 250, 500, 1000, 2000 freshly hatched juveniles of Meloidogyne incognita, and 2 females and 2 males of F. composticola were released in each plate. Observations on prey consumed were recorded after 24 and 48 hrs. of deliverance. Prey consumption of F. composticola boosted as the number of prey increased from 250 to 2000 per plate. At prey density of 500 per plate, maximum per cent consumption was observed and minimum at prey density 2000 per plate. Maximum predation found at a prey population density of 2000 individuals and minimum in 250 individuals per plate. This finding led to the conclusion of increased contacts between prey and predator at higher densities. In the pot experiment, plant height and shoot weight were reduced significantly over untreated control at 500 J2 and above. Root weight increased at 500 and 1000 levels, though it was similar to the control at 2000 level due to poor root development at this level. The number of galls and egg masses of M. incognita and final population of predator increased with increasing inoculum level of M. incognita.
Effect of intercropping on the parasitoids, Encarsia spp. and Trichogramma spp. in cotton fields, India
Authors: Devi Suman , Ram Pala , Rolania Krishna 
Published: June 2020

AbstractIntercropping in cotton is of great significance, which helps to reduce the population of insect pests by attracting natural enemies to the field and helping to get stabilized yield and high profit advantage. The study was conducted with 4 intercrops, viz., sesame,Sesamum indicumL.; pigeonpea,Cajanus cajanL.; pearl millet,Pennisetum glaucumL.; and sorghum,Sorghum bicolorL. in an experimental area during 2016 and 2017 autumn season. The objective was to study the population of parasitoids influenced by the intercrops in cotton. This is a triangular relationship between the host, parasitoids, and environment. AsEncarsiaspp. (Hymenoptera: Aphelinidae) andTrichogrammaspp. (Hymenoptera: Trichogrammatidae) are the main parasitoids of insect pests of cotton, thus the study was undertaken on these parasitoids. The results revealed that the highest parasitization of whitefly,Bemisia tabaci(Gennadius) pupae byEncarsiaspp., was recorded in cotton-pigeonpea 1:1 (33.22%), which was at par with cotton-pigeonpea 2:1 (32.16%), whereas the second highest one was in cotton-sesame 1:1 (27.33%), while the lowest parasitization was recorded in the control (16.16%). On the activity ofTrichogrammaspp., the significant highest percent was recorded in cotton-sesame 1:1 (10.93%), while no activity was recorded in cotton-pigeonpea, cotton-sorghum, cotton-pearl millet, and control treatments.
Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases
Authors: dos Reis Neto Edgard Torres , Kakehasi Adriana Maria , de Medeiros Pinheiro Marcelo , Ferreira Gilda Aparecida , Marques Cláudia Diniz Lopes , da Mota Licia Maria Henrique , dos Santos Paiva Eduardo , Pileggi Gecilmara Cristina Salviato , Sato Emília Inoue , Reis Ana Paula Monteiro Gomides , Xavier Ricardo Machado , Provenza José Roberto 
Published: June 2020

AbstractHydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in the treatment of rheumatic diseases and have recently become the focus of attention because of the ongoing COVID-19 pandemic. Rheumatologists have been using antimalarials to manage patients with chronic immune-mediated inflammatory rheumatic diseases for decades. It is an appropriate time to review their immunomodulatory and anti-inflammatory mechanisms impact on disease activity and survival of systemic lupus erythematosus patient, including antiplatelet effect, metabolic and lipid benefits. We also discuss possible adverse effects, adding a practical and comprehensive approach to monitoring rheumatic patients during treatment with these drugs.
The effect of patellar facet angle on patellofemoral alignment and arthritis progression in posterior-stabilized total knee arthroplasty without patellar resurfacing
Authors: Kim Chang-Wan , Lee Chang-Rack , Huh Tae-Yung 
Published: June 2020

Abstract
Background
The purpose of this study was to evaluate the effect of patellar facet angle on pre- and postoperative patellofemoral alignment and the progress of arthritis of the patellofemoral joint in posterior-stabilized total knee arthroplasty (PS TKA) without patellar resurfacing.

Methods
Patients who had a PS TKA for a varus osteoarthritic knee who were followed up for more than 2 years were included in this study. The radiologic and clinical outcomes were compared between 72 knees (group A) whose patellar facet angle was greater than 126° (> 126°) and 32 knees (group B) whose patellar facet angle was smaller than or equal to 126° (≤ 126°). For the radiologic assessment, the Kellgren-Lawrence grade, mechanical femorotibial angle, Insall-Salvati ratio, patellar tilt angle, patellar displacement and the osteosclerosis of the patellar ridge were evaluated. The range of motion (ROM) and patient-reported outcomes (the Knee Society knee score, the Knee Society function score, the Feller patellar score, and the Kujala patellofemoral score) were used for the clinical assessment.

Results
The preoperative patellar tilt angle was 9.8° (standard deviation [SD] 5.5) and 14.6° (SD 4.1) in group A and group B, respectively, a significant difference (p < 0.001). Other preoperative radiologic parameters and preoperative patient-reported outcomes and ROM showed no significant difference between the two groups (all parameters (p > 0.05). At the last-follow-up, 22 knees (30.6%) showed progression of osteosclerosis of the patellar ridge in group A and 13 knees (40.6%) showed progression of osteosclerosis in group B (p = 0.371). The postoperative radiologic and clinical outcomes showed no significant difference between the two groups (all parameters, p > 0.05).

Conclusions
Although a narrow patellar facet angle was related to an increase of lateral tilting of the patella, it showed no impact on the preoperative clinical assessment. The radiologic and clinical outcomes evaluated after the PS TKA showed no statistical difference according to the patellar shape. Although the patellar shape evaluated by the patellar facet angle can partially affect the preoperative patellofemoral alignment, this study result indicated insignificant clinical relevance of the patellar shape in the PS TKA.
Breast cancer imaging features as a predictor of the hormonal receptor status, HER2neu expression and molecular subtype
Authors: Algazzar Maged Abdelfattah Ali , Elsayed Elsayed El-Mekkawy , Alhanafy Alshimaa Mahmoud , Mousa Waleed Abdelfattah 
Published: June 2020

Abstract
Background
Determination of the hormonal receptor (HR) status, HER2neu expression, and the molecular subtype has valuable diagnostic, therapeutic, and prognostic implications for breast cancer as breast cancer stratification during the last two decades has become dependent upon the underlying biology. The aim of this study is to assess the correlation between imaging features of breast cancer and the HR status, HER2neu expression, and the molecular subtype. Sixty breast cancer patients underwent breast ultrasound, mammography, and MRI evaluation. Pathological evaluation using immunohistochemistry and FISH was used to detect the HR status, HER2/neu expression, and the molecular subtype. Those findings were then correlated with the radiologic data.

Results
HR-positive tumors were associated with posterior acoustic shadowing (34/44, 77.3%; p = 0.004). Hormonal-negative tumors presenting as masses were more likely circumscribed on US and MRI compared to hormonal positive mass tumors (6/14, 42.9% vs 3/36, 7.7%; p = 0.003 on US and 6/13, 46.3% vs 3/36, 8.3%; P = 0.007 on MRI) and had malignant DCE kinetics with washout curves compared to the hormonal positive group (10/16, 62.5% vs 4/44, 9.1%; P < 0.001). HER2neu-positive tumors were significantly associated with calcifications and multifocality on mammography compared to HER2neu-negative group (9/13, 69% vs 12/34, 25.5%; P = 0.007) and (7/13, 53% vs 3/47, 6%; P < 0.001). TNBC and HER2neu-enriched were associated with washout kinetic curve pattern (57.1% and 66.7%, respectively). TNBCs were associated with circumscribed margins on US and MRI (6/9, 66.7%; P < 0.001).

Conclusion
Microcalcifications, margins, posterior acoustic features, and malignant washout kinetics strongly correlate with the hormonal receptor status, HER2neu status, and molecular subtype of breast cancer. These findings may suggest the molecular subtype of breast cancer and further expand the role of imaging.
Closed versus conventional IV catheter in performing coronary CT Angiography
Authors: Harraz Mohamed M. , Abouissa Ahmed H. , Kamr Wael H. 
Published: June 2020

Abstract
Background
The purpose of this study was to compare the performance of a closed IV catheter system (CICS) with conventional IV catheters for IV contrast infusion in terms of contrast enhancement and associated complications during coronary CT angiography.
It is a retrospective study of 54 patients for whom a follow-up CCTA was requested were included for this study. Those patients had previous experience with the insertion of a 18 g conventional IV catheter which allows a flow rate of ≥ 6 ml/s and the complications during injection were registered. Patients were informed that a new IV catheter (The BD Nexiva™ Diffusics™ Closed IV Catheter System 22 g while still meeting a high flow rate > 6 m/s) will be used for their examination. We analyzed mean vascular attenuations in the ascending aorta, left main coronary artery, left ventricular (LV) cavity, and descending aorta (DA). Their feedback was collected regarding pain and the number of trials for catheter insertion. In addition, the access site was evaluated for any complication e.g. perforation, contrast extravasation or contamination.

Result
All patients were very satisfied with the new cannula. The catheter was inserted from the first trials. No one has perforation or extravasation. Mean vascular attenuations of the left main coronary artery, LV cavity, and DA were significantly higher during the use 0f the BD Nexiva™ Diffusics™ Closed IV Catheter System (all P ≤ 0.001).

Conclusion
Although the CICS has a small lumen, it allows a high flow rate; therefore, IV access required for CCTA can be secured with higher vascular attenuation and fewer complications. It is encouraged to use the CIVC system for CT angiographic studies, in particular CCTA.