bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating the potential effects of COVID-19 pandemic on food commodity prices and nutrition security in Nepal
Authors: Singh Samrat , Nourozi Sara , Acharya Laxman , Thapa Sridhar 
Published: October 2020

Abstract
The objective of the paper is to analyse changes in food commodity prices and estimate the potential effects of food price change on nutrition security in Nepal in the context of COVID-19 contagion control measures. It presents a comparative intra-country observational study design looking at events before and during the pandemic (after implementation of contagion control measures). The study design includes three districts, enabling comparison between diverse agro-ecological zones and geographical contexts. The methodology consists of primary data collection, modelling and quantitative analysis. The analysis is based on actual school meal food baskets which represent culturally and nutritionally optimised food baskets, developed by the local community and notional typical household food baskets. End May/early June 2020 is the ‘Post-COVID-19’ reference point, the same time period in 2019 i.e. June 2019 is the ‘Pre-COVID-19’ reference point. The study finds a substantial increase in food commodity prices across food groups and districts with marked inter-district variation. For school meal basket, all micronutrients show large average declines ranging from 9⋅5 % for zinc to 11 % for vitamin-A. For household food baskets on average, vitamin-A reduced 37 % followed by iron at 19 %, reduction in zinc is low due to the high zinc content in whole grain cereals. COVID-19 control measures are likely to have contributed to substantial price inflation over the reference period with potentially damaging effects on nutrition security in Nepal with serious implications for vulnerable populations.
A dual-tube sampling technique for snowpack studies
Authors: Dallmayr Remi , Freitag Johannes , Hörhold Maria , Laepple Thomas , Lemburg Johannes , Della-Lunga Damiano , Wilhelms Frank 
Published: October 2020

AbstractThe validity of any glaciological paleo proxy used to interpret climate records is based on the level of understanding of their transfer from the atmosphere into the ice sheet and their recording in the snowpack. Large spatial noise in snow properties is observed, as the wind constantly redistributes the deposited snow at the surface routed by the local topography. To increase the signal-to-noise ratio and getting a representative estimate of snow properties with respect to the high spatial variability, a large number of snow profiles is needed. However, the classical way of obtaining profiles via snow-pits is time and energy-consuming, and thus unfavourable for large surface sampling programs. In response, we present a dual-tube technique to sample the upper metre of the snowpack at a variable depth resolution with high efficiency. The developed device is robust and avoids contact with the samples by exhibiting two tubes attached alongside each other in order to (1) contain the snow core sample and (2) to access the bottom of the sample, respectively. We demonstrate the performance of the technique through two case studies in East Antarctica where we analysed the variability of water isotopes at a 100 m and 5 km spatial scales.
A multiproxy record of sedimentation, pedogenesis, and environmental history in the north of West Siberia during the late Pleistocene based on the Belaya Gora section
Authors: Sheinkman Vladimir , Sedov Sergey , Shumilovskikh Lyudmila S. , Bezrukova Elena , Dobrynin Dmitriy , Timireva Svetlana , Rusakov Alexey , Maksimov Fedor 
Published: October 2020

AbstractRecent revision of the Pleistocene glaciation boundaries in northern Eurasia has encouraged the search for nonglacial geological records of the environmental history of northern West Siberia. We studied an alluvial paleosol-sedimentary sequence of the high terrace of the Vakh River (middle Ob basin) to extract the indicators of environmental change since Marine Oxygen Isotope Stage (MIS) 6. Two levels of the buried paleosols are attributed to MIS 5 and MIS 3, as evidenced by U/Th and radiocarbon dates. Palynological and pedogenetic characteristics of the lower pedocomplex recorded the climate fluctuations during MIS 5, from thePicea-Larixtaiga environment during MIS 5e to the establishment of the tundra-steppe environment due to the cooling of MIS 5d or MIS 5b and partial recovery of boreal forests withPiceaandPinusin MIS 5c or MIS 5a. The upper paleosol level shows signs of cryogenic hydromorphic pedogenesis corresponding to the tundra landscape, with permafrost during MIS 3. Boulders incorporated in a laminated alluvial deposit between the paleosols are dropstones brought from the Enisei valley by ice rafting during the cold MIS 4. An abundance of eolian morphostructures on quartz grains from the sediments that overly the upper paleosol suggests a cold, dry, and windy environment during the MIS 2 cryochron.
Mechanisms linking the human gut microbiome to prophylactic and treatment strategies for COVID-19
Authors: Walton Gemma E. , Gibson Glenn R. , Hunter Kirsty A. 
Published: October 2020

AbstractThe recent COVID-19 pandemic has altered the face of biology, social interaction and public health worldwide. It has had a destructive effect upon millions of people and is approaching a devastating one million fatalities. Emerging evidence has suggested a link between the infection and gut microbiome status. This is one of the several factors that may contribute towards severity of infection. Given the fact that the gut is heavily linked to immunity, inflammatory status and the ability to challenge pathogens, it is worthwhile to consider dietary intervention of the gut microbiota as means of potentially challenging the viral outcome. In this context, probiotics and prebiotics have been used to mitigate similar respiratory infections. Here, we summarise links between the gut microbiome and COVID-19 infection, as well as propose mechanisms whereby probiotic and prebiotic interventions may act.
Genetic characterization and divergence studies of maize (Zea maysL.) lines developed from landraces indigenous to North Eastern Hill Region (NEHR) of India
Authors: Naveenkumar K. L. , Sen Devyani , Vashum Shimreiso , Sanjenbam Miranda 
Published: October 2020

AbstractThe current study focused on characterization of the underlying genetic divergence in inbred lines developed from local landraces of North Eastern Hill Region of India – a designated Asiatic maize diversity centre – following six generations of inbreeding. Substantial genetic differentiation was indicated based on very high to moderateFstvalues for 22 of the 38 simple sequence repeat markers studied. STRUCTURE analysis partitioned the subset into two distinct and one admixture subgroup (Populations I, II and III respectively) accompanied by a significant reduction in heterozygosity. Population II was further subdivided into subpopulations Pop-M9 and Pop-T9. Nei's pairwise genetic distance and populationFstvalues indicated that Populations I and II were more divergent with neighbour joining clustering analysis clearly defining landraces originating from the states of Tripura (Population II) and Sikkim (Population I) as most divergent. Principal coordinates analysis could explain 31.26% of the variation present in the subgroups wherein Population I was more variable. Analysis of molecular variance andFstcoefficients (P< 0.001) indicated 17% population structuring with 55% variation detected for individuals within populations. These results combined with the presence of phenotypic variability in the subgroups for yield traits supported by results of a preliminary partial diallel analysis strongly suggest the existence of distinct heterotic groups. Divergence studies are crucial for exploiting heterosis, and the current study would go a long way to help establish a germplasm base for developing varieties with improved agronomic performance and surer commercial prospects no reports of which are available thus far.
Searching for low-mass companions around white dwarfs and subdwarfs from Kepler field
Authors: Krzesinski Jurek , Blokesz Adam 
Published: October 2020

AbstractKnowing the late stages of the stellar evolution is crucial for understanding the fate of planets around subdwarfs and white dwarfs. Simulations by (Staff et al.2016) show, that exoplanets engulfed in the extending stellar envelope will quickly spiral down onto the parent star. Therefore, we do not expect to find planets on close by orbits to the subdwarfs (Blokesz et al.2019) or white dwarfs. However, the recent observation of planetary debris around WD 1145+017 white dwarf suggests, there might exists planets farther away from these stars. Using binarograms, O-C diagrams and Fourier transform for the Kepler space telescope data, we investigate a problem of missing planets around white dwarfs in binary systems, single white dwarfs and subdwarfs type B. The last ones, being the only stars which (due to the lack of hydrogen) go directly to the white dwarf cooling track after their red giant phase.
The chemical structure of the hot pulsating DB white dwarf KIC 08626021 from asteroseismology
Authors: Charpinet S. , Brassard P. , Giammichele N. , Fontaine Gilles 
Published: October 2020

AbstractGiammichele et al. (2018) proposed a full determination, largely independent of evolution calculations, of the chemical composition and stratification inside the hot pulsating DB white dwarf KIC 08626021. However, Timmes et al. (2018) pointed out that neglecting the effects of neutrino cooling, such as in the static models used in Giammichele et al. study, could impact significantly the derived seismic solution and compromise conclusions drawn upon it. Here we present a reanalysis of KIC 08626021, using improved static models which now incorporate more realistic luminosity profiles that reflect the still significant energy losses induced by neutrino emission mechanisms in hot DB white dwarfs. We show that this effect has only a limited impact on the derived seismic model properties and, more importantly, that all the conclusions brought by Giammichele et al. (2018) remain entirely valid.
Realistic models of Globular Clusters with white dwarfs, neutron stars and black holes using GPU supercomputer
Authors: Kayastha Bhusan , Wang Long , Berczik Peter , Pang Xiaoying , Arca Sedda Manuel , Kamlah Albrecht , Spurzem Rainer 
Published: October 2020

AbstractWe present some results from the DRAGON simulations, a set of four direct N-body simulations of globular clusters (GCs) with a million stars and five percent initial (primordial) binaries. These simulations were undertaken with the NBODY6++GPU code, which allowed us to follow dynamical and stellar evolution of individual stars and binaries, formation and evolution of white dwarfs, neutron stars, and black holes, and the effect of a galactic tidal field. The simulations are the largest existing models of a realistic globular cluster over its full lifetime of 12 billion years. In particular we will show here an investigation of the population of binaries including compact objects (such as white dwarfs - cataclysmic variables and merging black hole binaries in the model as counterparts of LIGO/Virgo sources); their distribution in the cluster and evolution with time.
Neutral helium line profiles through the simulation of local interactions
Authors: Tremblay Patrick , Beauchamp Alain , Bergeron Pierre 
Published: October 2020

AbstractFor the past 25 years, we have been considering the Stark effect for neutral helium lines in DB white dwarfs using the standard Stark broadening theory in both the impact regime (in the center of the lines) and the quasi-static regime (in the wings) for the electrons, while neglecting the effect of ions in motion. Although this is probably a good approximation based on previous theoretical work, the transition between the two regimes for the electrons and the contribution of the ions very near the core might be poorly represented. To better represent these particularities, we report here the results of a new series of simulations that treat the local dynamics and interactions of both electrons and ions around a neutral helium atom. From these simulations, we produce new improved line profiles, which we compare with our previous analytical results.
Statistics of white dwarf properties in intermediate polars
Authors: Suleimanov Valery F. , Doroshenko Victor A. , Werner Klaus 
Published: October 2020

AbstractMany intermediate polars are hard X-ray sources. The theory of their hard X-ray radiation is well developed and allows us to determine white dwarf masse in this kind of cataclysmic variables. Here we present the results of determination the masses of 35 white dwarfs in the intermediate polars observed by observatories NuSTAR (10 sources) and Swift/BAT (25 sources). The corresponding mass accrerion rates and the luminosity function were also derived due to accurate distance to the sources well known now after Gaia DR2.
Double degenerate candidates in the open cluster NGC 6633
Authors: Barnett Joseph W. , Williams Kurtis A. 
Published: October 2020

AbstractThe study of white dwarfs, the end stage of stellar evolution for more than 95% of stars, is critical to bettering our understanding of the late stages of the lives of low mass stars. In particular, the post main sequence evolution of binary star systems is complex, and the identification and analysis of double degenerate systems is a crucial step in constraining models of binary star systems. Binary white dwarfs in open star clusters are particularly useful because cluster parameters such as distance, metal content, and total system age are more tightly constrained than for field double degenerates. Here we use the precision astrometry from the Gaia Data Release 2 catalog to study two other white dwarfs which were identified as candidate double degenerates in the field of the open star cluster NGC 6633. One of the two objects, LAWDS 4, is found to have astrometric properties fully consistent with that of the cluster. In such a case, the object is significantly overluminous for a single white dwarf, strongly indicating binarity. The second candidate binary, LAWDS 7, appears to be inconsistent with cluster membership, though a more thorough analysis is necessary to properly quantify the probability. At present we are proceeding to model the photometric and spectroscopic data for both objects as if they were cluster member double degenerates. Results of this latter analysis are forthcoming. Our results will add crucial data to the study of binary star evolution in open star clusters.
Evolution and asteroseismology of ultra-massive DA white dwarfs
Authors: De Gerónimo F. C. , Córsico A. H. , Camisassa M. E. , Althaus L. G. 
Published: October 2020

AbstractUltra-massive (⩾M⊙) oxygen/neon (ONe) core white dwarfs (WDs) are the result of the evolution of isolated progenitor stars with masses above 6−M⊙. It is expected that hydrogen-rich (DA) ultra-massive WDs harbor crystallized cores at the typical temperatures of the ZZ Ceti instability strip. These stars offer a unique opportunity to study the processes of crystallization and to infer their core chemical composition. We present a study of the evolution and asteroseismology of ultra-massive DA WDs. We found that all pulsating WDs known to date with M⩾1.1M⊙ should have more than 80% of their mass crystallized, if a ONe-core is assumed. Finally, we present a complete asteroseismological analysis to the well known ZZ Ceti BPM 37093 and a preliminary analysis to GD 518 and SDSS J0840+5222.
What can ISM and non-photospheric highly ionised lines in white dwarf spectra reveal about the β CMa tunnel?
Authors: Finch Nicolle L. , Preval S. P. , Barstow M. A. , Casewell S. L. , Ayres T. , Welsh B. , Bainbridge M. , Reindl N. 
Published: October 2020

AbstractWhite dwarfs are useful objects with which to study the local interstellar medium (ISM). High ionisation state absorption features that cannot be attributed to the photosphere or the ISM have been observed along the line-of-sight to a number of white dwarf stars. Suggested origins of these lines include ionisation from past supernovae, stellar winds, circumstellar disks, photoionisation from nearby hot stars or also from the white dwarf itself. In this study we consider the origin of these non-photospheric highly ionised lines in two stars towards a rarefied region of the galaxy known as the extended β CMa Tunnel. We present preliminary results from our analysis of the first of these two stars.
A Bayesian analysis of white dwarfs in open clusters observed with Gaia
Authors: Jeffery Elizabeth J. , von Hippel Ted , Robinson Elliot , van Dyk David , Stenning David 
Published: October 2020

AbstractWe analyze individual white dwarfs in open clusters observed by Gaia. In particular, we determine ages when different model ingredients are used. We also explore fundamental properties of the white dwarfs, including temperature and mass, when using different filter combinations. Such tests are important to understanding any systematic effects when applying similar techniques to field stars.
Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth
Authors: Yao Nan , Wang Chen-Ran , Liu Ming-Qun , Li Ying-Jie , Chen Wei-Min , Li Zheng-Qiu , Qi Qi , Lu Jin-Jian , Fan Chun-Lin , Chen Min-Feng , Qi Ming , Li Xiao-Bo , Hong Jian , Zhang Dong-Mei , Ye Wen-Cai 
Published: October 2020

AbstractEpidermal growth factor receptor (EGFR) activation plays a pivotal role in EGFR-driven non-small cell lung cancer (NSCLC) and is considered as a key target of molecular targeted therapy. EGFR tyrosine kinase inhibitors (TKIs) have been canonically used in NSCLC treatment. However, prevalent innate and acquired resistances and EGFR kinase-independent pro-survival properties limit the clinical efficacy of EGFR TKIs. Therefore, the discovery of novel EGFR degraders is a promising approach towards improving therapeutic efficacy and overcoming drug resistance. Here, we identified a 23-hydroxybetulinic acid derivative, namely DPBA, as a novel EGFR small-molecule ligand. It exerted potent in vitro and in vivo anticancer activity in both EGFR wild type and mutant NSCLC by degrading EGFR. Mechanistic studies disclosed that DPBA binds to the EGFR extracellular domain at sites differing from those of EGF and EGFR. DPBA did not induce EGFR dimerization, phosphorylation, and ubiquitination, but it significantly promoted EGFR degradation and repressed downstream survival pathways. Further analyses showed that DPBA induced clathrin-independent EGFR endocytosis mediated by flotillin-dependent lipid rafts and unaffected by EGFR TKIs. Activation of the early and late endosome markers rab5 and rab7 but not the recycling endosome marker rab11 was involved in DPBA-induced EGFR lysosomal degradation. The present study offers a new EGFR ligand for EGFR pharmacological degradation and proposes it as a potential treatment for EGFR-positive NSCLC, particularly NSCLC with innate or acquired EGFR TKI resistance. DPBA can also serve as a chemical probe in the studies on EGFR trafficking and degradation.
Optotracing for selective fluorescence-based detection, visualization and quantification of live S. aureus in real-time
Authors: Butina Karen , Tomac Ana , Choong Ferdinand X. , Shirani Hamid , Nilsson K. Peter R. , Löffler Susanne , Richter-Dahlfors Agneta 
Published: October 2020

AbstractMethods for bacterial detection are needed to advance the infection research and diagnostics. Based on conformation-sensitive fluorescent tracer molecules, optotracing was recently established for dynamic detection and visualization of structural amyloids and polysaccharides in the biofilm matrix of gram-negative bacteria. Here, we extend the use of optotracing for detection of gram-positive bacteria, focussing on the clinically relevant opportunistic human pathogen Staphylococcus aureus. We identify a donor-acceptor-donor-type optotracer, whose binding-induced fluorescence enables real-time detection, quantification, and visualization of S. aureus in monoculture and when mixed with gram-negative Salmonella Enteritidis. An algorithm-based automated high-throughput screen of 1920 S. aureus transposon mutants recognized the cell envelope as the binding target, which was corroborated by super-resolution microscopy of bacterial cells and spectroscopic analysis of purified cell wall components. The binding event was essentially governed by hydrophobic interactions, which permitted custom-designed tuning of the binding selectivity towards S. aureus versus Enterococcus faecalis by appropriate selection of buffer conditions. Collectively this work demonstrates optotracing as an enabling technology relevant for any field of basic and applied research, where visualization and detection of S. aureus is needed.
Identification of 4-carboxyglutamate residue sites based on position based statistical feature and multiple classification
Authors: Shah Asghar Ali , Khan Yaser Daanial 
Published: October 2020

AbstractGlutamic acid is an alpha-amino acid used by all living beings in protein biosynthesis. One of the important glutamic acid modifications is post-translationally modified 4-carboxyglutamate. It has a significant role in blood coagulation. 4-carboxyglumates are required for the binding of calcium ions. On the contrary, this modification can also cause different diseases such as bone resorption, osteoporosis, papilloma, and plaque atherosclerosis. Considering its importance, it is necessary to predict the occurrence of glutamic acid carboxylation in amino acid stretches. As there is no computational based prediction model available to identify 4-carboxyglutamate modification, this study is, therefore, designed to predict 4-carboxyglutamate sites with a less computational cost. A machine learning model is devised with a Multilayered Perceptron (MLP) classifier using Chou’s 5-step rule. It may help in learning statistical moments and based on this learning, the prediction is to be made accurately either it is 4-carboxyglutamate residue site or detected residue site having no 4-carboxyglutamate. Prediction accuracy of the proposed model is 94% using an independent set test, while obtained prediction accuracy is 99% by self-consistency tests.
Phylogenetic inference enables reconstruction of a long-overlooked outbreak of almond leaf scorch disease (Xylella fastidiosa) in Europe
Authors: Moralejo Eduardo , Gomila Margarita , Montesinos Marina , Borràs David , Pascual Aura , Nieto Alicia , Adrover Francesc , Gost Pere A. , Seguí Guillem , Busquets Antonio , Jurado-Rivera José A. , Quetglas Bàrbara , García Juan de Dios , Beidas Omar , Juan Andreu , Velasco-Amo María P. , Landa Blanca B. , Olmo Diego 
Published: October 2020

AbstractThe recent introductions of the bacterium Xylella fastidiosa (Xf) into Europe are linked to the international plant trade. However, both how and when these entries occurred remains poorly understood. Here, we show how almond scorch leaf disease, which affects ~79% of almond trees in Majorca (Spain) and was previously attributed to fungal pathogens, was in fact triggered by the introduction of Xf around 1993 and subsequently spread to grapevines (Pierceʼs disease). We reconstructed the progression of almond leaf scorch disease by using broad phylogenetic evidence supported by epidemiological data. Bayesian phylogenetic inference predicted that both Xf subspecies found in Majorca, fastidiosa ST1 (95% highest posterior density, HPD: 1990–1997) and multiplex ST81 (95% HPD: 1991–1998), shared their most recent common ancestors with Californian Xf populations associated with almonds and grapevines. Consistent with this chronology, Xf-DNA infections were identified in tree rings dating to 1998. Our findings uncover a previously unknown scenario in Europe and reveal how Pierce’s disease reached the continent.