bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of chronic kidney disease in 29 893 patients undergoing transcatheter or surgical aortic valve replacement from the German Aortic Valve Registry
Authors: Mas-Peiro Silvia , Faerber Gloria , Bon Dimitra , Herrmann Eva , Bauer Timm , Bleiziffer Sabine , Bekeredjian Raffi , Böning Andreas , Frerker Christian , Beckmann Andreas , Möllmann Helge , Vasa-Nicotera Mariuca , Ensminger Stephan , Hamm Christian W , Beyersdorf Friedhelm , Fichtlscherer Stephan , Walther Thomas ,   for the GARY-Executive Board, Beyersdorf Friedhelm , Hamm Christian W , Cremer Jochen , Kuck Karl-Heinz , Ince Hüseyin , Andresen Dietrich , Mohr Friedrich W , Sack Stefan , Walther Thomas , Ensminger Stephan , Haude Michael , Linke Axel , M—llmann Helge , Wahlers Thorsten , Welz Armin , Beckmann Andreas , Papoutsis Konstantinos 
Published: November 2020

Abstract

OBJECTIVES
Chronic kidney disease (CKD) is a key risk factor in patients undergoing transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR). We analysed the impact of estimated glomerular filtration rate (eGFR) and CKD stages on their mid-term survival.

METHODS
Data from 29 893 patients enrolled in the German Aortic Valve registry from January 2011 to December 2015 receiving TAVI (n = 12 834) or SAVR (n = 17 059) at 88 sites were included. The impact of renal impairment, as measured by eGFR and CKD stages, was investigated. The primary end-point was 1-year cumulative all-cause mortality.

RESULTS
Higher CKD stages were significantly associated to lower in-hospital, 30-day- and 1-year survival rates. Both TAVI- and SAVR-treated patients in CKD 3a, 3b, 4 and 5 stages showed significant and gradually increasing HR values for 1-year all-cause mortality. The same trend persisted in multivariable analysis, although HR values for CKD 3a and 5 did not reach significance in TAVI patients, whereas CKD 4 + 5 did not reach statistical significance in SAVR. Likewise, eGFR as a continuous variable was a significant predictor for 1-year mortality, with the best cut-off points being 47.4 ml/min/1.73 m2 for TAVI and 59.8 ml/min/1.73 m2 for SAVR. Significant 8.6% and 9.0% increases in 1-year mortality were observed for every 5-ml reduction in eGFR for TAVI and SAVR, respectively.

CONCLUSIONS
CKD ≥3b and CKD ≥3a are the independent major risk factors for mortality in patients undergoing TAVI and SAVR, respectively. In the overall population of patients with severe aortic stenosis, an appropriate stratification based on CKD substage may contribute to a better selection of patients suitable for such therapies.
Brugada syndrome and syncope: a practical approach for diagnosis and treatment
Authors: Mascia Giuseppe , Bona Roberta Della , Ameri Pietro , Canepa Marco , Porto Italo , Parati Gianfranco , Crotti Lia , Brignole Michele 
Published: November 2020

AbstractSyncope in patients with Brugada electrocardiogram pattern may represent a conundrum in the decision algorithm because incidental benign forms, especially neurally mediated syncope, are very frequent in this syndrome similarly to the general population. Arrhythmic syncope in Brugada syndrome typically results from a self-terminating sustained ventricular tachycardia or paroxysmal ventricular fibrillation, potentially leading to sudden cardiac death. Distinguishing syncope due to malignant arrhythmias from a benign form is often difficult unless an electrocardiogram is recorded during the episode. We performed a review of the existing literature and propose a practical approach for diagnosis and treatment of the patients with Brugada syndrome and syncope.
Present GPS velocity field along 1999 Izmit rupture zone: evidence for continuing afterslip 20 yr after the earthquake
Authors: Özarpacı Seda , Doğan Uğur , Ergintav Semih , Çakır Ziyadin , Özdemir Alpay , Floyd Michael , Reilinger Robert 
Published: November 2020

SUMMARYIn order to better assess earthquake hazards, it is vital to have a better understanding of the spatial and temporal characteristics of fault creep that occur on ruptured faults during the period following major earthquakes. Towards this end, we use new far-field GPS velocities from continuous stations (extending ∼50–70 km from the fault) and updated near-fault GPS survey observations, with high temporal and spatial density, to constrain active deformation along the Mw7.4, 1999 Izmit, Turkey Earthquake fault. We interpret and model deformation as resulting from post-seismic afterslip on the coseismic fault. In the broadest sense, our results demonstrate that logarithmically decaying post-seismic afterslip continues at a significant level 20 yr following 1999 Earthquake. Elastic models indicate substantially shallower apparent locking depths at present than prior to the 1999 Earthquake, consistent with continuing afterslip on the coseismic fault at depth. High-density, near-fault GPS observations indicate shallow creep on the upper 1–2 km of the coseismic fault, with variable rates, the highest and most clearly defined of which reach ∼12 mm yr−1 (10–15 mm yr−1, 95 per cent c.i.) near the epicentre between 2014–2016. This amounts to ∼half the long-term slip deficit rate.
Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome
Authors: Testoni Giorgia , Olmeda Bárbara , Duran Jordi , López-Rodríguez Elena , Aguilera Mònica , Hernández-Álvarez María Isabel , Prats Neus , Pérez-Gil Jesús , Guinovart Joan J 
Published: November 2020

AbstractThe glycogenin knockout mouse is a model of Glycogen Storage Disease type XV. These animals show high perinatal mortality (90%) due to respiratory failure. The lungs of glycogenin-deficient embryos and P0 mice have a lower glycogen content than that of wild-type counterparts. Embryonic lungs were found to have decreased levels of mature surfactant proteins SP-B and SP-C, together with incomplete processing of precursors. Furthermore, non-surviving pups showed collapsed sacculi, which may be linked to a significantly reduced amount of surfactant proteins. A similar pattern was observed in glycogen synthase1-deficient mice, which are devoid of glycogen in the lungs and are also affected by high perinatal mortality due to atelectasis.These results indicate that glycogen availability is a key factor for the burst of surfactant production required to ensure correct lung expansion at the establishment of air breathing. Our findings confirm that glycogen deficiency in lungs can cause respiratory distress syndrome and suggest that mutations in glycogenin and glycogen synthase 1 genes may underlie cases of idiopathic neonatal death.
Sharp Hardy Space Estimates for Multipliers
Authors: Grafakos Loukas , Park Bae Jun 
Published: November 2020

Abstract
We provide an improvement of Calderón and Torchinsky’s version [ 5] of the Hörmander multiplier theorem on Hardy spaces $H^p$ ($0&lt;p&lt;\infty $), substituting the Sobolev space $L_s^2(A_0)$ by the Lorentz–Sobolev space $L_s^{\tau ^{(s,p)},\min (1,p) }(A_0)$, where $\tau ^{(s,p)} =\frac{n}{s-(n/\min{(1,p)}-n)}$ and $A_0$ is the annulus $\{\xi \in{\mathbb{R}}^n:\,\, 1/2&lt;|\xi |&lt;2\}$. Our theorem also extends that of Grafakos and Slavíková [ 10] to the range $0 &lt; p \leqslant 1$. Our result is sharp in the sense that the preceding Lorentz–Sobolev space cannot be replaced by a larger Lorentz–Sobolev space $L^{r,q}_s(A_0)$ with $r&lt; \tau ^{(s,p)} $ or $q&gt;\min (1,p)$.
Practice- and individual-level antibiotic prescribing associated with antibiotic treatment non-response in respiratory tract infections: a national retrospective observational study
Authors: Peng Zhuoxin , Hayen Andrew , Liu Bette 
Published: November 2020

Abstract

Objectives
Antibiotic overuse results in adverse clinical outcomes. This study quantified the independent contributions of practice- and individual patient-level antibiotic prescribing to antibiotic treatment non-response in respiratory tract infections (RTIs) in primary care.

Methods
RTI episodes with antibiotic prescribed in 2018 were extracted from an Australian national general practice database. Practices were classified into tertiles by total antibiotic prescriptions per patient and ratios of broad- to narrow-spectrum antibiotic prescriptions. The association between practice- and individual patient-level antibiotic prescribing in the previous year and antibiotic treatment non-response (defined as prescription of a different antibiotic) ≤30 days after the initial RTI episode was quantified using generalized estimating equations.

Results
Of 84 597 RTI episodes with antibiotics prescribed in 558 practices, 5570 (6.6%) episodes of treatment non-response were identified. Patients with high individual-level antibiotic prescribing (≥4 prescriptions/year) had an increased risk of treatment non-response (versus no prescriptions/year: OR = 1.64, 95% CI = 1.52–1.77). At the practice level, there was no significant association between total antibiotic prescriptions per patient and treatment non-response (high versus low: OR = 0.99, 95% CI = 0.92–1.06). RTI episodes in practices with high broad- to narrow-spectrum antibiotic ratios had an increased risk of treatment non-response (versus low-ratio practices: OR = 1.14, 95% CI = 1.05–1.23); this association was only observed among patients with &lt;4 antibiotic prescriptions/year.

Conclusions
The general practice-level broad- to narrow-spectrum antibiotic ratio was a predictor of RTI antibiotic treatment non-response in patients with lower individual-level antibiotic use. The measure of practice-level antibiotic prescribing could potentially guide the improvement of antibiotic treatment.
Dietary replacement of fish meal by defatted and fermented soybean meals with taurine supplementation for pompano fish: effects on growth performance, nutrient digestibility, and biological parameters in a long-term feeding period
Authors: Nguyen Hung Phuc , Do Thinh Van , Tran Hau Duc 
Published: November 2020

Abstract
A 16-wk growth trial was conducted to examine the effects of dietary replacement of fish meal by defatted soybean meal (SBM) and fermented soybean meal (FSBM) with taurine supplementation on growth performance, nutrient apparent digestibility coefficient (ADC) and biological parameters of pompano fish. The FSBM was produced by fermenting SBM with Lactobacillus spp. Seven isonitrogenous and isoenergetic diets were formulated to replace 35% or 50% of fish meal by SBM or FSBM with taurine supplementation. The diets are denoted as follows: FM, SBM35, SBM35T, FSBM35T, SBM50, SBM50T, and FSBM50T. The FM (the basal diet) contained fish meal as a main source of dietary protein. Taurine was supplemented to SBM35T, FSBM35T, SBM50T, and FSBM50T at the level of 15 g/kg diet. Pompano juveniles with an initial body weight (BW) of 80 g reared in floating net cages were fed the experimental diets twice daily for 16 wk. Results showed that the final BW, weight gain, and feed conversion ratio of fish fed SBM35 and SBM50 were significantly lower than those of fish fed FM (P &lt; 0.05), indicating that the replacement of fish meal by SBM at the rate of 35% in the diet is excessive for pompano. Supplementation of taurine to the SBM-included diets significantly increased growth performance and feed utilization (P &lt; 0.05); however, these diets did not restore the performance back to a level equivalent to that of fish offered the basal diet. Meanwhile, fish fed FSBM35T had comparable growth and feed performances to those fed FM. Hematocrit values, total biliary bile acid levels, whole body lipid contents, and tissue taurine concentrations of fish fed SBM35 and SBM50 were the lowest among the treatments, but these parameters were improved by taurine supplementation and FSBM inclusion in the diet. Taurine supplementation increased lipid ADC, and SBM fermentation slightly enhanced both lipid and protein ADCs of the fish. These findings suggest that the combination of FSBM and taurine supplementation is an effective way to improve growth performance, nutrient digestibility, and biological parameters, and that FSBM with taurine supplementation can replace 35% of fish meal in pompano diets without any negative effects on growth and feed performances in a long-term feeding period.
Effect of wavy wall strut fuel injector on shock wave development and mixing enhancement of fuel and air for a scramjet combustor
Authors: Kummitha Obula Reddy , Pandey K M 
Published: November 2020

Abstract
The shear mixing and streamline vortices are the notable parameters to influence the air–fuel mixing in hypersonic flows. The shock wave development and Mach number significantly influence the shear mixing phenomenon. Hence, this research introduced an unconventional strut and tested its performance for the generation of shock waves at different flow conditions (M = 2,4,6). The Reynolds-averaged Navier–Stokes equations are solved to evaluate the performance of the new strut. Both the DLR scramjet strut injector and wavy wall strut injector are assessed for the shear mixing development. Turbulence for the association of shock waves, mixing layer, and the boundary layer has been modeled with the SST k-ω model. The variation in shock development and its interactions are investigated further with an increase in Mach number. The scramjet flow structure differentiation found the increased number of oblique shock waves with the wavy wall strut fuel injector. It increases the turbulence level with increased streamline vortices, turbulent intensity, and turbulent kinetic energy. The shock wave generation analysis at different Mach numbers (M = 2,4,6) found fewer interactions between the shock wave and shear layer with increased Mach number. From the examination of shock wave generation and its interaction with the shear layer and analysis of turbulent parameters, it is found that the wavy wall strut has an appreciable effect on shock-induced blend augmentation of fuel and air.
Alternative tactics in male African ground squirrels: the impact of variable rainfall on condition and physiology
Authors: O’Brien Kelsey A , Waterman Jane M , Bennett Nigel C 
Published: November 2020

Abstract
Alternative reproductive tactics occur when conspecifics of the same sex use different behavioral processes to maximize reproductive success. Resource availability can have significant impacts on the proximate factors impacting the success and persistence of alternative tactics, such as an individual’s physiology, immunity, and body condition. Male Cape ground squirrels (Xerus inauris) display two alternative tactics, with some mature males dispersing from their natal groups and joining bands of nonrelated males (band males), whereas others do not disperse and remain philopatric in their natal groups past sexual maturation (natal males). Despite differences in metabolism, home ranges, and behavior, there is no difference in reproductive success between the two tactics, allowing us to test if rainfall (as a measure of primary productivity) influences body condition and physiological indices in tactics when fitness is equal. Over a period of 6 years, rainfall was positively related to body condition (mass–spine length residuals) in band males (N = 76), but not in natal males (N = 75). When we followed 18 males prior to and after dispersal, we also found a positive relationship between body condition and age following dispersal, but not prior to dispersal, and natal males maintained a better body condition in low rainfall years. During 2 years of low rainfall, band males (N = 39) had higher total ectoparasite abundance, and white blood cell differentials, implying they are less able to tolerate parasitic infection than natal males (N = 31). We found no difference in bacterial growth inhibition between tactics, suggesting that band and natal males both are equally resistant to parasites. The poorer body condition of band males during lower rainfall suggests they are less tolerant to parasites in these years. Dispersal during years of low rainfall thus may increase the costs to body condition and parasite infection, but the reproductive benefit of overlapping with more females may contribute to maintaining equal fitness between tactics.
Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium
Authors: Peres Lauren C , Bethea Traci N , Camacho Tareq F , Bandera Elisa V , Beeghly-Fadiel Alicia , Chyn Deanna L , Harris Holly R , Joslin Charlotte E , Moorman Patricia G , Myers Evan , Ochs-Balcom Heather M , Rosenow Will , Setiawan V Wendy , Wu Anna H , Rosenberg Lynn , Schildkraut Joellen M 
Published: November 2020

Abstract

Background
The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women.

Methods
We used data from 4 case-control studies and 3 case-control studies nested within prospective cohorts in the Ovarian Cancer in Women of African Ancestry Consortium to estimate race-specific associations of 10 known or suspected EOC risk factors using logistic regression. Using the Bruzzi method, race-specific population attributable risks (PAR) were estimated for each risk factor individually and collectively, including groupings of exposures (reproductive factors and modifiable factors). All statistical tests were 2-sided.

Results
Among 3244 White EOC cases and 9638 controls and 1052 AA EOC cases and 2410 controls, AA women had a statistically significantly higher PAR (false discovery rate [FDR] P &lt; .001) for first-degree family history of breast cancer (PAR = 10.1%, 95% confidence interval [CI] = 6.5% to 13.7%) compared with White women (PAR = 2.6%, 95% CI = 0.8% to 4.4%). After multiple test correction, AA women had a higher PAR than White women when evaluating all risk factors collectively (PAR = 61.6%, 95% CI = 48.6% to 71.3% vs PAR = 43.0%, 95% CI = 32.8% to 51.4%, respectively; FDR P = .06) and for modifiable exposures, including body mass index, oral contraceptives, aspirin, and body powder (PAR = 36.0%, 95% CI = 21.0% to 48.8% vs PAR = 13.8%, 95% CI = 4.5% to 21.8%, respectively; FDR P = .04).

Conclusions
Collectively, the selected risk factors accounted for slightly more of the risk among AA than White women, and interventions to reduce EOC incidence that are focused on multiple modifiable risk factors may be slightly more beneficial to AA women than White women at risk for EOC.
Effects of desiccation of seeds in nine species with morphophysiological dormancy on germination and embryo growth
Authors: Copete Miguel A , Herranz José M , Herranz Raquel , Copete Elena , Ferrandis Pablo 
Published: November 2020

Abstract

Aims
In species with morphophysiological seed dormancy (MPD), little is known about the effects of desiccation of imbibed seeds on embryo growth and germination. We studied seed responses to dehydration in nine species with different levels of MPD.

Methods
For each species, a control test was conducted by keeping seeds permanently hydrated and exposed to the optimal stratification–incubation sequence to promote embryo growth. Simultaneously, tests were run in which seed stratification was interrupted for 1 month by desiccation at room temperature.

Important Findings
In Clematis vitalba and Ribes alpinum, with nondeep simple MPD, desiccation affected neither embryo growth nor seed viability, but the desiccation led to a decrease of germinative ability in R. alpinum by 16%. The seeds of Narcissus pseudonarcissus subsp. munozii-garmendiae, with deep simple epicotyl MPD, tolerated desiccation in different embryo growth stages, but their germinative ability decreased slightly. The response of species with complex levels of MPD to desiccation was more variable: Delphinium fissum subsp. sordidum, with intermediate complex MPD, and Anthriscus sylvestris and Meum athamanticum, both with deep complex MPD, tolerated desiccation. In contrast, Ribes uva-crispa with nondeep complex MPD, Lonicera pyrenaica with intermediate complex MPD and Chaerophyllum aureum with deep complex MPD, had diminished germination ability by desiccation. Although seeds of the species with simple levels of MPD tolerated desiccation, those of some species with complex levels were also highly tolerant. Thus, desiccation did not induce secondary dormancy in late embryo growth stages. The desiccation tolerance of imbibed seeds of most of the nine species may show their adaptability to climate change in the Mediterranean region.
Predicting morbidity in older travellers during a short-term stay in the tropics: the ELDEST study
Authors: Vlot Jessica A , Vive Marissa G D , Brockhoff Henricus J , van Genderen Pieter J J , Trompenaars Marie-Christine E , van Steenbergen James E , Visser Leonardus G 
Published: November 2020

Abstract

Background
Older persons may suffer more from travel-related health problems because of ageing and underlying chronic disorders. Knowledge on who is more likely to have these health problems helps to tailor travel health advice more specifically. This study aimed to determine predictors of travel-related morbidity in older travellers by assessing their pre-travel characteristics and performance using physical and cognitive functioning tests.

Methods
Multicentre prospective cohort study among older travellers (≥60 years) who consulted one of the participating Dutch travel clinics. Handgrip strength and cognitive performance were measured pre-travel. Participants completed questionnaires before departure and 1 and 4 weeks after return. A diary recorded health complaints during travel until 2-week post-travel.

Results
In total, 477 travellers completed the study (follow-up rate of 97%). Participants’ median age was 66 years. The most visited regions were South-East Asia (34%) and South Asia (14%). Median travel duration was 19 days. Polypharmacy (≥5 medications per day) was not uncommon (16%). The median Charlson Comorbidity Index (CCI) score was 0. Self-reported travel-related infectious diseases concerned primarily respiratory tract infections (21%) and gastroenteritis (10%) whereas non-infectious complaints were injuries (13%), peripheral edema (12%) and dehydration (3%). Medical assistance was sought by 18%, mostly post-travel from their general practitioner (87%). Self-reported physical and mental health-related quality of life significantly improved during and after travel. Predictors for an increased risk of travel-related morbidity were higher CCI score, more travel experience, longer travel duration, higher number of daily medications, visiting northern Africa or South-East and East Asia, and phone and social media use.

Conclusion
Older Dutch travellers are generally fit, well-prepared and suffer not only from common infectious health problems, but also from injuries. Travel improved their self-perceived health. The predictors could be used to identify the more at-risk older traveller and to decrease travel-related morbidity by optimizing pre-travel advice.
The Nuremberg Trial in Megillat Esther
Authors: Ron Zvi 
Published: November 2020

Abstract
There is a very popular teaching in Orthodox circles1 that the small letters found in the writing of the names of the sons of Haman in Megillat Esther are a reference to the year of the Nuremberg trials and the ten Nazis hanged at that time. In this article we will explore where this teaching originated, what it is based on, and what its message is understood to be.