bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified Endoscopic Dacryocystorhinostomy Using the Middle Uncinate Process Approach
Authors: Yang Jing , Cao Zhiwei , Gu Zhaowei 
Published: April 2020

Purpose:
Endoscopic dacryocystorhinostomy (EDCR) is advantageous in that it avoids facial scar formation, does not damage the medial canthus ligament, and recovers quickly. The main purpose of EDCR is to establish a fistula large enough to completely expose the lacrimal sac and avoid complications. Accurate location of lacrimal sac and complete opening of lacrimal sac are the keys to successful operation. However, due to the individual differences in the size of the lacrimal sac and the anatomical structure of the nasal cavity, it is difficult to determine the location of the lacrimal sac during the operation. Most patients need to place dilatation tubes after operation, which may lead to some defects. To explore the clinical effects of modified dacryocystorhinostomy using nasal endoscopy through the middle uncinate process approach for the treatment of chronic dacryocystitis and nasolacrimal duct obstruction.

Methods:
Sixty-nine patients (71 eyes) with chronic dacryocystitis and nasolacrimal duct obstruction underwent modified dacryocystorhinostomy using nasal endoscopy. Modified methods included changes in surgical approach, incision of the anterior wall of the lacrimal sac, and treatment of adherent mucosa.

Results:
In all 71 eyes, no serious complications occurred. The anatomical success rate was 93.0% (66/71) and the symptomatic success rate was 97.2% (69/71). None of the patients underwent conversion to an open method.

Conclusion:
Modified dacryocystorhinostomy using nasal endoscopy is advantageous in terms of shorter operation time, accurate dacryocystorhinostomy location, less bleeding, relatively simple operation, no requirement for dilation tube insertion, and better effects than conventional dacryocystorhinostomy using nasal endoscopy. Modified dacryocystorhinostomy is a safer and more effective method to treat chronic dacryocystitis-nasolacrimal duct obstruction.
A 26-Year-Old Woman With Diplopia and Nystagmus
Authors: Anderson William J. , Sharma Aseem , Guzman Miguel A. , Chung Sophia M. 
Published: April 2020

Abstract:
A 26-year-old woman presented for a routine contact lens evaluation but was found to have a subtle right sixth nerve paresis and adducting nystagmus of the left eye. She reported horizontal diplopia on far right gaze as well as subjective right-sided weakness and poor balance for 1 year. Brain and spinal MRI revealed multiple cystic lesions with variable enhancement throughout the posterior fossa and cervical spinal cord. These MRI findings were highly suspicious for an infectious central nervous system process, such as neurocysticercosis; however, primary or metastatic tumors were also important considerations. Tumor location and imaging characteristics were most helpful in differentiating among these etiologies. A brain biopsy ultimately established the diagnosis of a rosette-forming glioneuronal tumor.
Optic Neuropathy in Charcot–Marie–Tooth Disease
Authors: Hamedani Ali G. , Wilson James A. , Avery Robert A. , Scherer Steven S. 
Published: April 2020

Background:
Charcot–Marie–Tooth disease Type 2A (CMT2A) presents with optic atrophy in a subset of patients, but the prevalence and severity of optic nerve involvement in relation to other CMT subtypes has not been explored.

Methods:
Patients with genetically confirmed CMT2A (n = 5), CMT1A (n = 9) and CMTX1 (n = 10) underwent high- and low-contrast acuity testing using Sloan letter charts, and circumpapillary retinal nerve fiber layer (RNFL) and macular total retinal, RNFL, and ganglion cell layer/inner plexiform layer thickness was measured using spectral domain optical coherence tomography (OCT). We used age- and gender-adjusted linear regression to compare contrast acuity and retinal thickness between CMT groups.

Results:
One of 5 patients with CMT2A had optic nerve atrophy (binocular high-contrast acuity equivalent 20/160, mean circumpapillary RNFL 47.5 μm). The other patients with CMT2A had normal high- and low-contrast acuity and retinal thickness, and there were no significant differences between patients with CMT2A, CMT1A, and CMTX1.

Conclusions:
Optic atrophy occurs in some patients with CMT2A, but in others, there is no discernible optic nerve involvement. This suggests that optic neuropathy is specific to certain MFN2 mutations in CMT2A and that low-contrast acuity or OCT is of limited value as a disease-wide biomarker.
Human olfactory communication: current challenges and future prospects
Authors: Roberts S. Craig , Havlíček Jan , Schaal Benoist 
Published: April 2020

Although anthropologists frequently report the centrality of odours in the daily lives and cultural beliefs of many small-scale communities, Western scholars have historically considered the sense of smell as minimally involved in human communication. Here, we suggest that the origin and persistence of this latter view might be a consequence of the fact that most research is conducted on participants from Western societies who, collectively, were ratherold(adults),deodorizedanddesensitized(ODD) to various aspects of olfactory perception. The view is rapidly changing, however, and this themed issue provides a timely overview of the current state-of-the-art on human chemocommunication. Based on evolutionary models of communication, the papers cover both general mechanisms of odour production by ‘senders’ and odour perception by ‘receivers’. Focus on specific functional contexts includes reciprocal impact of odours between infants and mothers, the role of odour in mate choice and how odours communicate emotion and disease. Finally, a position paper outlines pitfalls and opportunities for the future, against the context of the replication crisis in psychology. We believe a more nuanced view of human chemical communication is within our grasp if we can continue to develop inter-disciplinary insights and expand research activities beyond ODD people.This article is part of the Theo Murphy meeting issue ‘Olfactory communication in humans’.
Decoding the social volatilome by tracking rapid context-dependent odour change
Authors: Roberts S. Craig , Misztal Pawel K. , Langford Ben 
Published: April 2020

Odours can have a significant influence on the outcome of social interactions. However, we have yet to characterize the chemical signature of any specific social cue in human body odour, and we know little about how changes in social context influence odour chemistry. Here, we argue that adoption of emerging analytical techniques from other disciplines, such as atmospheric chemistry, might become game-changing tools in this endeavour. First, we describe the use of online chemical ionization time-of-flight mass spectrometry to sensitively measure many hundreds of gas-phase volatile organic compounds in real time. By analysing ambient air emanating from undisturbed individuals or groups, the technique enables a continuous recording of an instantaneous odour change in response to external stimuli and changing social context. This has considerable advantages over the traditional approach of periodic sampling for analysis by gas chromatography. We also discuss multivariate statistical approaches, such as positive matrix factorization, that can effectively sift through this complex datastream to identify linked groups of compounds that probably underpin functional chemosignals. In combination, these innovations offer new avenues for addressing outstanding questions concerning olfactory communication in humans and other species, as well as in related fields using odour, such as biometrics and disease diagnostics.This article is part of the Theo Murphy meeting issue ‘Olfactory communication in humans’.
Major histocompatibility complex-associated odour preferences and human mate choice: near and far horizons
Authors: Havlíček Jan , Winternitz Jamie , Roberts S. Craig 
Published: April 2020

The major histocompatibility complex (MHC) is a core part of the adaptive immune system. As in other vertebrate taxa, it may also affect human chemical communication via odour-based mate preferences, with greater attraction towards MHC-dissimilar partners. However, despite some well-known findings, the available evidence is equivocal and made complicated by varied approaches to quantifying human mate choice. To address this, we here conduct comprehensive meta-analyses focusing on studies assessing: (i) genomic mate selection, (ii) relationship satisfaction, (iii) odour preference, and (iv) all studies combined. Analysis of genomic studies reveals no association between MHC-dissimilarity and mate choice in actual couples; however, MHC effects appear to be independent of the genomic background. The effect of MHC-dissimilarity on relationship satisfaction was not significant, and we found evidence for publication bias in studies on this area. There was also no significant association between MHC-dissimilarity and odour preferences. Finally, combining effect sizes from all genomic, relationship satisfaction, odour preference and previous mate choice studies into an overall estimate showed no overall significant effect of MHC-similarity on human mate selection. Based on these findings, we make a set of recommendations for future studies, focusing both on aspects that should be implemented immediately and those that lurk on the far horizon. We need larger samples with greater geographical and cultural diversity that control for genome-wide similarity. We also need more focus on mechanisms of MHC-associated odour preferences and on MHC-associated pregnancy loss.
This article is part of the Theo Murphy meeting issue ‘Olfactory communication in humans’.
Interdisciplinary challenges for elucidating human olfactory attractiveness
Authors: Ferdenzi Camille , Richard Ortegón Stéphane , Delplanque Sylvain , Baldovini Nicolas , Bensafi Moustafa 
Published: April 2020

Many species use chemicals to communicate. In humans, there is increasing evidence that chemicals conveyed by the body are extremely important in interpersonal relationships. However, many aspects of chemical communication remain to be explored to fully understand this function in humans. The aim of this article is to identify relevant challenges in this field, with a focus on human attractiveness in the context of reproduction, and to put forward roadmaps for future studies that will hopefully extend to a wider range of social interactions. The first challenge consists in not being limited to body (mal)odours from the axilla. Preliminary data on how the odour of the face and head is perceived are presented. Second, there is a crucial need to increase our knowledge of the chemical bases of human chemical communication. Third, cross-cultural approaches must not be overlooked, because they have a major input in understanding the universal and culture-specific aspects of chemical communication. Fourth, the influence of specific cultural practices such as contraceptive and fragrance use is likely to be prominent and, therefore, needs to be well described. The fifth and last challenge for research projects in this field is the integration of different disciplines such as behavioural sciences, social sciences, neurosciences and microbiology.
This article is part of the Theo Murphy meeting issue ‘Olfactory communication in humans’.
People expressing olfactory and visual cues of disease are less liked
Authors: Sarolidou Georgia , Axelsson John , Kimball Bruce A. , Sundelin Tina , Regenbogen Christina , Lundström Johan N. , Lekander Mats , Olsson Mats J. 
Published: April 2020

For humans, like other social animals, behaviour acts as a first line of defence against pathogens. A key component is the ability to detect subtle perceptual cues of sick conspecifics. The present study assessed the effects of endotoxin-induced olfactory and visual sickness cues on liking, as well as potential involved mechanisms. Seventy-seven participants were exposed to sick and healthy facial pictures and body odours from the same individual in a 2 × 2 factorial design while disgust-related facial electromyography (EMG) was recorded. Following exposure, participants rated their liking of the person presented. In another session, participants also answered questionnaires on perceived vulnerability to disease, disgust sensitivity and health anxiety. Lower ratings of liking were linked to both facial and body odour disease cues as main effects. Disgust, as measured by EMG, did not seem to be the mediating mechanism, but participants who perceived themselves as more prone to disgust, and as more vulnerable to disease, liked presented persons less irrespectively of their health status. Concluding, olfactory and visual sickness cues that appear already a few hours after the experimental induction of systemic inflammation have implications for human sociality and may as such be a part of a behavioural defence against disease.
This article is part of the Theo Murphy meeting issue ‘Olfactory communication in humans’.
Limitations in odour simulation may originate from differential sensory embodiment
Authors: Arshamian Artin , Manko Patricia , Majid Asifa 
Published: April 2020

Across diverse lineages, animals communicate using chemosignals, but only humans communicateaboutchemical signals. Many studies have observed that compared with other sensory modalities, communication about smells is relatively rare and not always reliable. Recent cross-cultural studies, on the other hand, suggest some communities are more olfactorily oriented than previously supposed. Nevertheless, across the globe a general trend emerges where olfactory communication is relatively hard. We suggest here that this is in part because olfactory representations are different in kind: they have a low degree of embodiment, and are not easily expressed as primitives, thereby limiting the mental manipulations that can be performed with them. New exploratory data from Dutch children (9–12 year-olds) and adults support that mental imagery from olfaction is weak in comparison with vision and audition, and critically this is not affected by language development. Specifically, while visual and auditory imagery becomes more vivid with age, olfactory imagery shows no such development. This is consistent with the idea that olfactory representations are different in kind from representations from the other senses.This article is part of the Theo Murphy meeting issue ‘Olfactory communication in humans’.
Use of Physician Global Assessment (PGA) in Systemic lupus erythematosus: a systematic review of its psychometric properties
Authors: Chessa Elisabetta , Piga Matteo , Floris Alberto , Devilliers Hervé , Cauli Alberto , Arnaud Laurent 
Published: April 2020

ABSTRACTBackgroundPhysician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician’s judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA.MethodsThis SLR was conducted by two independent reviewers in accordance with the PRISMA statement. All articles published until the 1st of July 2019 in Pubmed were screened with no limitation about years of publication, language or patients’ age. Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1.ResultsThe literature search identified 91 studies. Face validity was reported in all the articles retrieved, in which the PGA was used alone or as part of composite indices (SRI, SFI, LLDAS, DORIS remission criteria). Content validity was reported in 89 studies. Construct validity was demonstrated by a good correlation (r≥0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarkers levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. A good responsiveness for PGA was shown in 8 studies. A high variability in scales was found, causing a wide range of reliability (ICC=0.67-0.98).ConclusionPGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring.
Piloting Forensic Tele-Mental Health Evaluations of Asylum Seekers
Authors: Green Aliza S. , Ruchman Samuel G. , Katz Craig L. , Singer Elizabeth K. 
Published: April 2020

AbstractProblemForensic mental health evaluations can provide critical evidence in the legal cases of individuals seeking asylum and other forms of protected immigration status. While the number of academically affiliated medical human rights programs has increased in recent years, there is still substantial unmet need for pro bono evaluations throughout the United States, especially for individuals in detention.ApproachThe Mount Sinai Human Rights Program launched its pilot Remote Evaluation Network in September 2019, with the aim to coordinate forensic mental health evaluations by telephone or video call for individuals who are unable to access in-person services. The authors recruited mental health clinicians from across the country, trained them in best practices in conducting forensic evaluations using telehealth platforms, and coordinated pro bono mental health evaluations of individuals seeking immigration relief. Remote forensic services have been a particularly relevant solution in the context of the COVID-19 pandemic.OutcomesThe Remote Evaluation Network consists of seventeen active evaluators. From December 2019 to April 2020, the pilot program has coordinated fifteen forensic evaluations of individuals seeking asylum and other forms of protected immigration status in six different states. All clinicians participated in a training module on best practices in conducting forensic evaluations by telephone; respondents to optional pre-and-post-module surveys reported an increase in comfort level with conducting telephonic evaluations after participating in the module.Next StepsWe will formally evaluate this pilot program’s services by assessing the quality of medico-legal affidavits from telephonic evaluations, tracking legal outcomes and qualitative feedback from attorneys, and investigating the acceptability of telephonic mental health evaluations among legal professionals. Future directions include expansion to new geographies, including individuals affected by the Migrant Protection Protocols or “Remain in Mexico” program.
Disentangling fine-scale effects of environment on malaria detection and infection to design risk-based disease surveillance systems in changing landscapes
Authors: Fornace Kimberly M , Reyes Ralph A , Macalinao Maria Lourdes M , Bareng Alison Paolo N , Luchavez Jennifer S , Hafalla Julius Clemence R , Espino Fe Esperanza J , Drakeley Chris J 
Published: April 2020

AbstractLandscape changes have complex effects on malaria transmission, disrupting social and ecological systems determining the spatial distribution of risk. Within Southeast Asia, forested landscapes are associated with both increased malaria transmission and reduced healthcare access. Here, we adapt an ecological modelling framework to identify how local environmental factors influence the spatial distributions of malaria infections, diagnostic sensitivity and detection probabilities in the Philippines. Using convenience sampling of health facility attendees and Bayesian latent process models, we demonstrate how risk-based surveillance incorporating forest data increases the probability of detecting malaria foci over three-fold and enables estimation of underlying distributions of malaria infections. We show the sensitivity of routine diagnostics varies spatially, with the decreased sensitivity in closed canopy forest areas limiting the utility of passive reporting to identify spatial patterns of transmission. By adjusting for diagnostic sensitivity and targeting spatial coverage of health systems, we develop a model approach for how to use landscape data within disease surveillance systems. Together, this illustrates the essential role of environmental data in designing risk-based surveillance to provide an operationally feasible and cost-effective method to characterise malaria transmission while accounting for imperfect detection.
Exploring health in the UK Biobank: associations with sociodemographic characteristics, psychosocial factors, lifestyle and environmental exposures
Authors: Mutz Julian , Roscoe Charlotte J. , Lewis Cathryn M. 
Published: April 2020

AbstractA greater understanding of factors associated with good health may help increase longevity and healthy life expectancy. Here we report associations between multiple health indicators and sociodemographic (age, sex, ethnicity, education, income and deprivation), psychosocial (loneliness and social isolation), lifestyle (smoking, alcohol intake, sleep, BMI, physical activity and stair climbing) and environmental (air pollution, noise and greenspace) factors, using data from 307,378 UK Biobank participants. Low income, being male, neighbourhood deprivation, loneliness, social isolation, short or long sleep duration, low or high BMI and smoking was associated with poor health. Walking, vigorous-intensity physical activity and more frequent alcohol intake was associated with good health. There was some evidence that airborne pollutants (PM2.5, PM10, and NO2) and noise (Lden) were associated with poor health, though findings were inconsistent in adjusted models. Our findings highlight the multifactorial nature of health, the importance of non-medical factors, such as loneliness, healthy lifestyle behaviours and weight management, and the need to examine efforts to improve health outcomes of individuals with low income.
Analysis of the mitigation strategies for COVID-19: from mathematical modelling perspective
Authors: Kassa S. M. , Njagarah H.J.B. , Terefe Y. A. 
Published: April 2020

AbstractIn this article, a mathematical model for the transmission of COVID-19 disease is formulated and analysed. It is shown that the model exhibits a backward bifurcation at ℛ0 = 1 when recovered individuals do not develop a permanent immunity for the disease. In the absence of reinfection, it is proved that the model is without backward bifurcation and the disease free equilibrium is globally asymptotically stable for ℛ0 < 1. By using available data, the model is validated and parameter values are estimated. The sensitivity of the value of ℛ0 to changes in any of the parameter values involved in its formula is analysed. Moreover, various mitigation strategies are investigated using the proposed model and it is observed that the asymptomatic infectious group of individuals may play the major role in the re-emergence of the disease in the future. Therefore, it is recommended that in the absence of vaccination, countries need to develop capacities to detect and isolate at least 30% of the asymptomatic infectious group of individuals while treating in isolation at least 50% of symptomatic patients to control the disease.