bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of 2D-fluoroscopy-based iliosacral screw osteosynthesis: results of a retrospective monocentric study
Authors: Rommens Pol Maria , Nolte Eva Mareike , Hopf Johannes , Wagner Daniel , Hofmann Alexander , Hessmann Martin 
Published: April 2020

Abstract
Introduction
Iliosacral screw osteosynthesis is a well-accepted procedure for stabilization of sacral fractures and iliosacral (fracture) dislocations.

Materials and Methods
In this monocentric study, safety and efficacy of conventional 2D-fluoroscopic-guided iliosacral screw insertion were evaluated.

Results
During a 10-year period (2005–2014), 98 patients between the age of 18 and 65 years received 207 iliosacral screws in 101 procedures. Average patient age was 43.2 years. There were 46 Type B and 40 Type C injuries in the AO/OTA classification, nine patients had a fragility fracture of the pelvis. In three patients, primary radiological data were missing. The indication for surgical treatment was a sacral fracture in 97 patients, a pure iliosacral dislocation in 37 patients and a fracture-dislocation in 31 patients. 70 procedures were performed with the patient in supine position, 31 with the patient in prone position. Surgery was done in a minimal-invasive technique in 76 patients, in 22 patients an open reduction was necessary before screw insertion. 81 patients received a unilateral, 17 patients a bilateral screw osteosynthesis. 199 screws were inserted in S1, only eight screws in S2. 65 patients received two screws unilaterally, ten patients two screws bilaterally. There were no vascular or neurologic complications. During in-hospital stay, there were seven complications, which needed 12 operative revisions: three wound infections, two hematomas, one screw malalignment and one early screw loosening. In 28 patients with 56 iliosacral screws, a pelvic CT-scan was performed during follow-up. A penetration of a cortical layer was diagnosed in 20 of these screws. All penetrations were seen in double screw osteosynthesis of S1. In none of the patients, complaints could be explained by the malalignment of these screws. Five operative revisions were performed during follow-up: two for screw loosening, two for fracture healing problems and one for screw malalignment. Metal removal was performed in 39 patients with 75 screws. 2D-fluoroscopic-guided iliosacral screw osteosynthesis is a safe and efficient procedure in clinical practice.

Discussion
A thorough preoperative evaluation of the morphology of the upper sacrum and careful operative procedure are indispensable. Fluoroscopic views in AP, lateral, inlet and outlet must allow recognition of all anatomical landmarks. The indication for double screw osteosynthesis in S1 should be taken with caution. Screw malalignments do not inevitably correlate with complaints.
The Bacillus anthracis class Ib ribonucleotide reductase subunit NrdF intrinsically selects manganese over iron
Authors: Grāve Kristīne , Griese Julia J. , Berggren Gustav , Bennett Matthew D. , Högbom Martin 
Published: April 2020

Abstract
Correct protein metallation in the complex mixture of the cell is a prerequisite for metalloprotein function. While some metals, such as Cu, are commonly chaperoned, specificity towards metals earlier in the Irving–Williams series is achieved through other means, the determinants of which are poorly understood. The dimetal carboxylate family of proteins provides an intriguing example, as different proteins, while sharing a common fold and the same 4-carboxylate 2-histidine coordination sphere, are known to require either a Fe/Fe, Mn/Fe or Mn/Mn cofactor for function. We previously showed that the R2lox proteins from this family spontaneously assemble the heterodinuclear Mn/Fe cofactor. Here we show that the class Ib ribonucleotide reductase R2 protein from Bacillus anthracis spontaneously assembles a Mn/Mn cofactor in vitro, under both aerobic and anoxic conditions, when the metal-free protein is subjected to incubation with MnII and FeII in equal concentrations. This observation provides an example of a protein scaffold intrinsically predisposed to defy the Irving–Williams series and supports the assumption that the Mn/Mn cofactor is the biologically relevant cofactor in vivo. Substitution of a second coordination sphere residue changes the spontaneous metallation of the protein to predominantly form a heterodinuclear Mn/Fe cofactor under aerobic conditions and a Mn/Mn metal center under anoxic conditions. Together, the results describe the intrinsic metal specificity of class Ib RNR and provide insight into control mechanisms for protein metallation.

Graphical Abstract
Towards a human-centred participatory approach to child social care recordkeeping
Authors: Shepherd Elizabeth , Hoyle Victoria , Lomas Elizabeth , Flinn Andrew , Sexton Anna 
Published: April 2020

AbstractIn 2019, there were over 75,000 children and young people in out-of-home care in England and Wales. Recent estimates suggest that up to half a million British people were in state or voluntary care as children, around 1% of the adult population. While individual experiences vary enormously by time and place, care-experienced people share in common the intensive documentation of their lives by social workers, educators, health professionals and associated practitioners. A complex, fragmented legislative and regulatory framework governs the creation and use of these records at the national level. Under UK law, a ‘care file’ must be retained for at least 75 years, so that a substantial legacy of care data is held across the public, voluntary and private sectors. MIRRA: Memory—Identity—Rights in Records—Access, a participatory research project co-produced with care leavers, investigated recordkeeping practices in child social care from multiple perspectives. Interviews, focus groups and workshops with stakeholders identified critical failings in the creation, use, management and access to care records, which do not account for the needs and capabilities of multiple stakeholders. These failings have a direct impact on the well-being and health of care-experienced people throughout their lives. MIRRA researchers developed a human-centred participatory recordkeeping approach to child social care, which this article describes. The approach combines the participatory continuum model (Rolan in Arch Sci 17(3):195–225. https://doi.org/10.1007/s10502-016-9267-7, 2017) and the capabilities approach to social work, rooting child social care recordkeeping in information rights principles. The article makes a contribution to the literature that discusses archival science within a human rights and ethics framework and reflects on trauma-informed practice for information professionals. It also provides guidance on practice improvements for child social care recording.
Flotillin membrane domains in cancer
Authors: Gauthier-Rouvière Cécile , Bodin Stéphane , Comunale Franck , Planchon Damien 
Published: April 2020

AbstractFlotillins 1 and 2 are two ubiquitous, highly conserved homologous proteins that assemble to form heterotetramers at the cytoplasmic face of the plasma membrane in cholesterol- and sphingolipid-enriched domains. Flotillin heterotetramers can assemble into large oligomers to form molecular scaffolds that regulate the clustering of at the plasma membrane and activity of several receptors. Moreover, flotillins are upregulated in many invasive carcinomas and also in sarcoma, and this is associated with poor prognosis and metastasis formation. When upregulated, flotillins promote plasma membrane invagination and induce an endocytic pathway that allows the targeting of cargo proteins in the late endosomal compartment in which flotillins accumulate. These late endosomes are not degradative, and participate in the recycling and secretion of protein cargos. The cargos of this Upregulated Flotillin–Induced Trafficking (UFIT) pathway include molecules involved in signaling, adhesion, and extracellular matrix remodeling, thus favoring the acquisition of an invasive cellular behavior leading to metastasis formation. Thus, flotillin presence from the plasma membrane to the late endosomal compartment influences the activity, and even modifies the trafficking and fate of key protein cargos, favoring the development of diseases, for instance tumors. This review summarizes the current knowledge on flotillins and their role in cancer development focusing on their function in cellular membrane remodeling and vesicular trafficking regulation.
Biofilms grown in aquatic microcosms affect mercury and selenium accumulation in Daphnia
Authors: Issa Semona , Ciesielski Tomasz Maciej , Mikkelsen Øyvind , Einum Sigurd , Jaspers Veerle L. B. 
Published: April 2020

AbstractExperiments examining mercury (Hg) toxicity in Daphnia are usually conducted in highly standardized conditions that prevent the formation of biofilm. Although such standardization has many advantages, extrapolation of results to natural conditions and inference of ecological effects is challenging. This is especially true since biofilms can accumulate metals/metalloids and play a key role in their transfer to higher trophic level organisms. In this study, we experimentally tested the effects of spontaneously appearing biofilm in Daphnia cultures on accumulation of Hg and its natural antagonist selenium (Se) in Daphnia magna. We added Hg (in the form of mercury (II) chloride) at two concentrations (0.2 µg/L and 2 µg/L) to experimental microcosms and measured the uptake of Hg and Se by D. magna in the presence and absence of biofilm. To test for consistent and replicable results, we ran two identical experimental sets one week apart. Biofilm presence significantly reduced the accumulation of Hg, while increasing the tissue Se content in D. magna, and these findings were reproducible across experimental sets. These findings indicate that highly standardized tests may not be adequate to predict the bioaccumulation and potential toxicity of metals/metalloids under natural conditions.
Model checking boot code from AWS data centers
Authors: Cook Byron , Khazem Kareem , Kroening Daniel , Tasiran Serdar , Tautschnig Michael , Tuttle Mark R. 
Published: April 2020

AbstractThis paper describes our experience with symbolic model checking in an industrial setting. We have proved that the initial boot code running in data centers at Amazon Web Services is memory safe, an essential step in establishing the security of any data center. Standard static analysis tools cannot be easily used on boot code without modification owing to issues not commonly found in higher-level code, including memory-mapped device interfaces, byte-level memory access, and linker scripts. This paper describes automated solutions to these issues and their implementation in the C Bounded Model Checker (CBMC). CBMC is now the first source-level static analysis tool to extract the memory layout described in a linker script for use in its analysis.
Evaluation of Water Quality Parameters in Marshes Zone Southern of Iraq Based on Remote Sensing and GIS Techniques
Authors: Hasab Hashim Ali , Jawad Hussain A. , Dibs Hayder , Hussain Hussain Musa , Al-Ansari Nadhir 
Published: April 2020

AbstractAl-Hawizeh Marsh is considered a major marsh in the south of Iraq with a longitude of 47° 32″–47° 45″ and latitude of 31° 30″–31° 42″, length of 80 km and width of 30 km, while the depth is from 1.5 to 4 m. It has a significant impact on the ecosystem and provides habitat for several types of living creatures. The surface water and the agricultural lands surrounding this marsh suffered from high level degrees of salinity. In the last decades, radical deterioration of water quality in this marsh happened because of the post-war-related events and several human activities. Landsat-8 data was used to predict and evaluate the spatial variation and map distributions of the salinity, SO4 and CaCO3 within Al-Hawizeh Marsh during the two seasons in the year 2017 based on the development of salinity and minerals mathematical equations. The evaluated values for salinity, SO4 and CaCO3 are found to be minimal in winter and maximum in autumn. The values of correlation coefficient (R2) between the real data and the equation results for the salinity, SO4 and CaCO3 during the two seasons are 0.95, 0.96 and 0.92, respectively.
Social Inequalities in Student Employment and the Local Labour Market
Authors: Jacob Marita , Gerth Maria , Weiss Felix 
Published: April 2020

AbstractThis article examines class-specific employment patterns among students in Germany, taking into account how different local labour market conditions affect the quantity and quality of jobs available to students. We argue that the availability of jobs affects social inequalities in student employment. In particular, we expect a stronger correlation between, on the one hand, the rate and quality of student employment and, on the other hand, students’ socioeconomic background in towns with a large pool of student labour, due to more competition for (good) jobs. Analysing data from German student surveys, we find that employment rates do not differ by social class background, but there are differences in the quality of their employment in terms of the fit between the job and the field of study. While we find that local labour market conditions affect student employment at a general level, in contrast to our expectation, tighter labour market conditions seem to involve little or no disadvantage for students from less privileged social backgrounds.
Characterization of lithological zones of the Isanlu sheet 225, North Central Nigeria, using aerogeophysical datasets
Authors: Akinsunmade Akinniyi , Nguyen Dinh Chau , Wojas Anna , Tomecka-Suchoń Sylwia 
Published: April 2020

AbstractGridded aeromagnetic and aeroradiometric datasets of Isanlu sheet 225 were processed and interpreted in order to map the geological structures and characteristic lithology, as well as potential mineral ore zones in the area. Recorded aeromagnetic data were reduced to the magnetic equator before filtering operations which enhanced the magnetic anomalies. Analytic signal map was created, and subsequently a model was generated along a selected profile for better interpretation of the subsurface materials. On the aeroradiometric data were performed both enhancement and statistical operations. The lithological zones were identified. They are metasedimentary rocks, migmatites and igneous rocks occupying varying proportions within the entire area. Some potential radioactive or precious metal ore zones were also localized. A major structure interpreted in the study area trends in the SE–NW direction. Other surface structures were also delineated and general orientation was evaluated. This information may serve as a valuable database for further prospective research and mineral exploration in the region.
Improved delineation of CT virtual bronchoscopy by ultrahigh-resolution CT: comparison among different reconstruction parameters
Authors: Adachi Takuya , Machida Haruhiko , Nishikawa Makiko , Arai Takahiro , Kariyasu Toshiya , Koyanagi Masamichi , Yokoyama Kenichi 
Published: April 2020

Abstract
Purpose
We compared the maximal recognizable bronchial bifurcation order (MRBBO) in CT virtual bronchoscopy (CTVB) using ultrahigh-resolution CT (UHRCT) and different reconstruction parameters.

Materials and methods
We enrolled 38 patients undergoing noncontrast chest CT by UHRCT and reconstructed CTVB utilizing 3 different combinations of reconstruction parameters, as classified into Group A (matrix size, 512; slice thickness, 1.0 mm), Group B (matrix size, 512; slice thickness, 0.5 mm), and Group C (matrix size, 1024; slice thickness, 0.25 mm). In right S1, left S1 + 2, and both S3 and S10, two reviewers counted the number of consecutively identified bronchial bifurcations to compare MRBBO among these groups using Kruskal–Wallis test.

Results
In these segments, MRBBO increased from Group A to C. MRBBO was significantly higher in Group C than in both Groups A and B in all the segments except left S10 (P < 0.05 for all). In left S10, it was significantly higher in Group C than in Group A (P < 0.05) but comparable between Groups B and C (P = 0.122).

Conclusions
MRBBO is higher in CTVB by UHRCT utilizing 1024-matrix size and 0.25-mm thickness than parameters currently recommended for CTVB (matrix size, 512; slice thickness, 0.5–1.0 mm).
Mobilisierung des Rechts: Organisierte Interessen und Verfassungsbeschwerden vor dem Bundesverfassungsgericht
Authors: Thierse Stefan 
Published: April 2020

ZusammenfassungVerfassungsbeschwerden werden nicht nur von Einzelpersonen erhoben, sondern auch von Unternehmen, Verbänden oder zivilgesellschaftlichen Interessengruppen. Gleichwohl sind die politischen Implikationen des Verfahrens von der Politikwissenschaft bisher kaum gewürdigt worden. Dies ist umso bemerkenswerter, als sogar die Rechtswissenschaft der Verfassungsbeschwerde eine Mobilisierungs- und Partizipationsfunktion zuerkennt. Vor diesem Hintergrund wirft der vorliegende Beitrag die folgende Frage auf: Unter welchen Bedingungen erreichen organisierte Interessen mithilfe einer Verfassungsbeschwerde eine breite Mobilisierung für ihre Anliegen? Eine Fuzzy-set-Analyse von 35 Verfassungsbeschwerden vor dem Bundesverfassungsgericht identifiziert zwei kausale Konfigurationen für das Phänomen verfassungsrechtlicher Mobilisierungsstrategien. Bei allen Unterschieden teilen diese Verfassungsbeschwerden den Umstand, dass sie von Mitgliederorganisationen erhoben werden, die in Karlsruhe Gesetze und Regierungsakte anfechten.
Medical Students’ Acquaintance with Core Concepts, Institutions and Guidelines on Good Scientific Practice: A Pre- and Post-questionnaire Survey
Authors: Fuerholzer Katharina , Schochow Maximilian , Peter Richard , Steger Florian 
Published: April 2020

AbstractGerman medical students are not sufficiently introduced to the ethical principles and pitfalls of scientific work. Therefore, a compulsory course on good scientific practice (GSP) has been developed and implemented into the curriculum of medical students, with the goal to foster scientific integrity and prevent scientific misconduct. Students’ knowledge and attitudes towards GSP were evaluated by a pre-post-teaching questionnaire survey (n = 239). Most participants initially had startling knowledge gaps in the field. Moreover, they were not acquainted with core institutions on GSP, the office of ombudsperson and the nationally binding guidelines on GSP. The pre-post-teaching comparison showed statistically significant improvement in all areas tested; moreover, after the course participants confided more trust in GSP institutions. Applying ethical rules into practice can be challenging; therefore, students need to learn to work independently with guidelines on GSP and should be introduced to institutions providing further guidance. As our study has shown, students are very willing to pursue a scientific career based on integrity and honesty, however, they lack the knowledge how to do so. In light of our results, we therefore recommend to integrate courses on GSP already at an early time into the mandatory curriculum of medical students.
Human Brain Atlases in Stroke Management
Authors: Nowinski Wieslaw L. 
Published: April 2020

AbstractStroke is a leading cause of death and a major cause of permanent disability. Its management is demanding because of variety of protocols, imaging modalities, pulse sequences, hemodynamic maps, criteria for treatment, and time constraints to promptly evaluate and treat. To cope with some of these issues, we propose novel, patented solutions in stroke management by employing multiple brain atlases for diagnosis, treatment, and prediction. Numerous and diverse CT and MRI scans are used: ARIC cohort, ischemic and hemorrhagic stroke CT cases, MRI cases with multiple pulse sequences, and 128 stroke CT patients, each with 170 variables and one year follow-up. The method employs brain atlases of anatomy, blood supply territories, and probabilistic stroke atlas. It rapidly maps an atlas to scan and provides atlas-assisted scan processing. Atlas-to-scan mapping is application-dependent and handles three types of regions of interest (ROIs): atlas-defined ROIs, atlas-quantified ROIs, and ROIs creating an atlas. An ROI is defined by atlas-guided anatomy or scan-derived pathology. The atlas defines ROI or quantifies it. A brain atlas potential has been illustrated in four atlas-assisted applications for stroke occurrence prediction and screening, rapid and automatic stroke diagnosis in emergency room, quantitative decision support in thrombolysis in ischemic stroke, and stroke outcome prediction and treatment assessment. The use of brain atlases in stroke has many potential advantages, including rapid processing, automated and robust handling, wide range of applications, and quantitative assessment. Further work is needed to enhance the developed prototypes, clinically validate proposed solutions, and introduce them to clinical practice.
The therapeutic landscape of advanced melanoma
Authors: Richtig Erika 
Published: April 2020

SummaryThe therapeutic landscape of advanced and metastatic melanoma has changed dramatically in the last ten years. Targeted therapies as well as checkpoint inhibitors and oncolytic viruses have launched a broad revolution within this field. First presented at ASCO 2011, changes in melanoma treatment giving “light at the end of the tunnel” have also changed the treatment of many other tumor entities. So oncologists all over the world can offer their patients these treatment options with higher efficacy than we ever had. But despite all optimism we are still losing about half of our patients with metastatic melanoma along the way. In this short review the therapeutic landscape of advanced melanoma is described.
Homologous repair deficiencies and current insights in clinical evaluation of PARP inhibitors in prostate cancer
Authors: Marhold Maximilian , Topakian Thaïs 
Published: April 2020

SummaryHomologous repair deficiency is a clinically relevant molecular aberration in prostate cancer. The goal of this short review is to summarize the study landscape of treatments targeting these aberrations through discussion of the most relevant clinical trials. Due to its shortness, this review does not claim to be exhaustive and a major focus is being laid on PARP inhibitors in clinical development for prostate cancer.
Adjuvant and neoadjuvant treatment of melanoma
Authors: Koelblinger Peter 
Published: April 2020

SummaryFor years, interferon alpha was the sole option in the adjuvant treatment of patients with completely resected melanoma with lymph node metastases and a high risk of disease recurrence, albeit being associated with a relatively low efficacy combined with significant toxicities. After the advent of immunotherapy and targeted therapy in locally advanced or metastatic melanoma at the beginning of the last decade, these therapeutic approaches have meanwhile also shown superior efficacy compared to previously used treatments or observation in the context of adjuvant therapy. Hence, adjuvant targeted or anti-PD1-antibody-based immunotherapy was incorporated into routine clinical practice to reduce the risk of tumor recurrence in affected patients in early 2018. Moreover, modern melanoma therapies are increasingly being investigated in a neoadjuvant setting in analogy to other solid malignancies. Considering the promising results reported so far, neoadjuvant immunotherapy might potentially become the treatment of choice in high-risk melanoma patients with macrometastatic disease in the near future.