bluuebunny/crossref_metadata_2025_split huggingface dataset:
The importance of human capital and the human organization management in a crisis situation
Authors: Lazarov Alexandru-Sebastian 
Published: August 2020

Abstract
The main attributes of an organizations are characterized as open and dynamic social systems, able to develop individually. In essence, an organization is a social system with human capacity, beyond the means of production, essential to the formation, operation and development of an organization. Interactions between people and the connections between them are important in achieving the goal of the organization. The objectives of the organization must coincide with the goals of the organization’s leadership and meet the needs of those involved in the production system, so the level of connection between human capital and resources is essential. Human capital is the most important factor for the organization, it represents the accumulation of professional skills, combined with the creativity and initiative of each person, together generating essential resources to the organization and producing services and materials meant to generate profit. Each organization invests in forming and developing the human capital in order to create specialists in the industrial branches that the organization develops. Satisfaction with the basic needs of employees is an essential factor in the organization’s development. If this is not the case, the human capital can be destabilized slightly and can cause the state of crisis. Defeating human primordial needs can lead to an increase in the state of crisis of the organization, thus being able to evolve until the collapse of the organization.
Human capital, in the event of a crisis, regardless of its nature, is the most important factor. The human factor decides how the crisis will be perceived and the means used to end the crisis.Knowing the human capital, the needs and especially the abilities of each employee can help the organization overcome a crisis moment easily and can solve an emergency without involving all the factors at its disposal.
Performance – Based Budgeting – an option or a necessity
Authors: Manta Andreea-Mariana 
Published: August 2020

Abstract
The paper aims to present the concept of Performance – Based Budgeting and its importance for the economic development of a country. Performance – Based Budgeting is applied since decades ago in countries like Sweden or USA, whilst the others may learn from the good practices examples offered by the two. The present research highlights the advantages of implementing this concept, the suitable ways for implementing it, the obstacles that are often encountered and important recommendations for improving its use. The research was based on the literature review of the publications and the official data available in the studied field. The results of the paper contributes to implementing Performance – Based Budgeting in Romania but also to improving its implementation in other countries. Therefore, the paper offers solutions to stimulate a sustainable economic development of a country. The conclusion will reveal if Performance-Based Budgeting is an option among other concepts or a strong necessity for nowadays economic challenges.
Influence of concurrent capecitabine based chemoradiotherapy with bevacizumab on the survival rate, late toxicity and health-related quality of life in locally advanced rectal cancer: a prospective phase II CRAB trial
Authors: Velenik Vaneja , Zadnik Vesna , Omejc Mirko , Grosek Jan , Tuta Mojca 
Published: August 2020

Abstract

Background
Few studies reported early results on efficacy, toxicity of combined modality treatment for locally advanced rectal cancer (LARC) by adding bevacizumab to preoperative chemoradiotherapy, but long-term data on survival, and late complications are lacking. Further, none of the studies reported on the assessment of quality of life (QOL).

Patients and methods
After more than 5 years of follow-up, we updated the results of our previous phase II trial in 61 patients with LARC treated with neoadjuvant capecitabine, radiotherapy and bevacizumab (CRAB study) before surgery and adjuvant chemotherapy. Secondary endpoints of updated analysis were local control (LC), disease free (DFS) and overall survival (OS), late toxicity and longitudinal health related QOL (before starting the treatment and one year after the treatment) with questionnaire EORTC QLQ-C30 and EORTC QLQ-CR38.

Results
Median follow-up was 67 months. During the follow-up period, 16 patients (26.7%) died. The 5-year OS, DFS and LC rate were 72.2%, 70% and 92.4%. Patients with pathological positive nodes or pathological T3–4 tumors had significantly worse survival than patients with pathological negative nodes or T0–2 tumors. Nine patients (14.8%) developed grade 33 late complications of combined modality treatment, first event 12 months and last 87 months after operation (median time 48 months). Based on EORTC QLQ-C30 scores one year after treatment there were no significant changes in global QOL and three symptoms (pain, insomnia and diarrhea), but physical and social functioning significantly decreased. Based on QLQ-CR38 scores body image scores significantly increase, problems with weight loss significantly decrease, but sexual dysfunction in men and chemotherapy side effects significantly increase.

Conclusions
Patients with LARC and high risk factors, such as positive pathological lymph nodes and high pathological T stage, deserve more aggressive treatment in the light of improving long-term survival results. Patients after multimodality treatment should be given greater attention to the regulation of individual aspects of quality of life and the occurrence of late side effects.
Key Metallurgical Parameters of Fe-Ni Production During 1984–1997 and 2007–2017 at the Ferronickel Smelter in Drenas
Authors: Bajraktari-Gashi Zarife , Zabeli Muharrem , Halilaj Behram 
Published: August 2020

Abstract
During 1984–1997, the ferronickel plant in Drenas used iron-nickel ore from the mines of the Republic of Kosovo: Glavica and Çikatove (Dushkaje and Suke) mines. However, during the years 2007–2017, when the plant started operating from the cessation of production, which was from 1998 to 2007, some types of iron-nickel ores from different countries began to be used, starting from iron-nickel ores from Kosovo, iron-nickel ores from Albania, ores from Indonesia, ores from the Philippines, ores from Guatemala, ores from Turkey and ores from Macedonia. The ore composition, however, is mainly oxide-laterite ore. Iron-nickel ores in the plant are characterised by high moisture content, a very important factor influencing the process of scraping the charge in rotary kilns and presenting in general. Among the iron-nickel ore used in the ferronickel plant, the ores from Albania are characterised due to their low moisture content when compared with the other ores as well as the high content of iron oxides, which affect the temperature rise inside the furnaces, as the iron ores play an important role in the pre-casting process in rotary kilns.
Metabolomic biomarkers of polycystic ovary syndrome related-obesity: a review of the literature
Authors: Vonica Camelia Larisa , Farcas Anca Daniela , Roman Gabriela , Muresan Andrada Alina , Fodor Adriana , Cernea Simona , Georgescu Carmen Emanuela 
Published: August 2020

Abstract

Background and objectives: Polycystic ovary syndrome (PCOS) displays a phenotype-dependent cardio-metabolic risk. By performing a systematic search of the literature, we aimed to summarize metabolomic signatures associated with obesity in PCOS women.

Data sources and study eligibility criteria: We conducted a comprehensive search including: Embase, PubMed, and Web of Science until 31st of May 2019. We used the terms: metabolomics and polycystic ovary syndrome. We excluded the following papers: animal studies, studies that included only lean PCOS women, reviews, meta-analyses, results of interventional studies, those that did not apply metabolomic techniques.

Results: The lipid signature in obese women with PCOS showed increased levels of free fatty acids (carnitine, adipic acid, linoleic acid, oleic acid) and lower levels of lysophosphatidylcholines and glycerolphosphocholine compared with non-obese PCOS women. Regarding carbohydrate metabolism, a decrease in citric and lactic acid levels characterized obese PCOS women. Decreased lactic acid in obese PCOS women suggests augmented insulin stimulated glucose muscle use in lean, but not in obese women. Considering amino acid metabolomic markers, valine, glycine, serine, threonine, isoleucine and lysine were higher in obese PCOS women. Patients with visceral obesity presented a diminished uptake of essential amino acids, BCAA, leucine and serine in the skeletal muscle. α-ketoglutarate was significantly higher in obese women with PCOS in comparison with lean women with PCOS, distinguishing these 2 subgroups of PCOS with high ‘predictive accuracy’.

Limitations: Overall, a small number of studies have focused on the impact of obesity on the metabolic fingerprints of PCOS women. There is need for properly controlled, high-quality studies.

Conclusions: There is compelling evidence of significant alterations in carbohydrate, lipid, and amino acid metabolism in women with PCOS and obesity. Metabolomics may identify new metabolic pathways involved in PCOS and improve our understanding of the complex relation between PCOS and obesity in order to personalize PCOS therapy.
Characterization of antibiotic resistance integrons harbored by Romanian Escherichia coli uropathogenic strains
Authors: Oprea Mihaela , Militaru Madalina Cornelia , Ciontea Adriana Simona , Cristea Daniela , Cristea Violeta , Usein Codruta Romanita 
Published: August 2020

Abstract
Because little is known about the integrons which constitute an important means of spreading resistance in bacteria circulating in Romania, this study aimed to detect antibiotic resistance gene cassettes embedded in integrons in a convenient collection of 60 ciprofloxacin-resistant Escherichia coli isolates of various phylogroups, associated with community-acquired urinary tract infections. Characterization of the integrons was accomplished by PCR, restriction fragment length polymorphism typing, and DNA sequencing of each identified type. More than half of the tested E. coli strains were positive for integrons of class 1 (31 strains) or 2 (1 strain). These strains derived more frequently from phylogenetic groups A (15 of 21 strains), B1 (10 of 14 strains), and F (3 of 4 strains), respectively. While 20 strains carried class 1 integrons which could be assigned to nine types, eleven strains carried integrons that lacked the 3’-end conserved segment. The attempts made to characterize the gene cassettes located within the variable region of the various integrons identified in this study revealed the presence of genes encoding resistance to trimethoprim, aminoglycosides, beta-lactams or chloramphenicol. The evidence of transferable resistance determinants already established in the autochthonous E. coli strains highlights the need for improved control of resistance-carrying bacteria.
Comparative Evaluation of RNAlater Solution and Snap Frozen Methods for Gene Expression Studies in Different Tissues
Authors: Ozkan Huseyin , Kerman Enes 
Published: August 2020

Abstract

Introduction: Freezing of tissues with liquid nitrogen is the most common method in studies performed at the RNA level. However, the use of RNA stabilization solutions has become a popular alternative method. The aim of this study is to investigate the effectiveness of RNAlater on RNA stabilization in different tissues.

Material and Methods: In this study, RNA were isolated from the lung, heart, liver and skeletal muscle tissues of rats that were frozen with liquid nitrogen (snap frozen, SF group) or stored in RNAlater solution (RL group), and the changes in concentration, purity, reference genes expression, and fold-change levels between groups were analyzed.

Results: In the RL group, the concentration of RNA isolated from the liver tissues was higher (P<0.05), whereas the A260/280 ratio was lower in the heart and liver tissues (P<0.05). PPIA and SRP72 genes were found to have lower Ct values in the heart tissues of rats in the RL group (P<0.05 and P<0.001, respectively) than the SF group. Expression levels of PPIA, ACTB, and SRP72 genes across the tissues were found to be different between the groups (P<0.05). The gene expression level examined in terms of fold-change was significantly different in the RL group (upregulated up to 4 folds and downregulated about 0.5 fold) (P< 0.05).

Conclusions: The results showed that RNAlater can maintain the RNA integrity and can also change the results of gene expression because it does not inhibit biological activity. The snap freezing method is more reliable because gene expression is more stable in tissues frozen with liquid nitrogen.
Carbapenemase Producing Enterobacterales in Romania: Investigating the Origins
Authors: Molnár Szabolcs , Vas Krisztina Eszter , Székely Edit 
Published: August 2020

Abstract
Carbapenemase-producing Enterobacterales (CPE) have emerged and spread in Romania since 2010. According to the reports of the EuSPACE (European survey of carbapenemase-producing Enterobacteriaceae) the epidemio-logical stage of the CPE expansion in Romania has shifted from sporadic occurrence in 2013 directly to inter-regional spread in 2014-2015. In this study we aimed to provide data from the timeframe when the dissemination of the carbapenemase genes in Romania began, by retrospectively analyzing CPE strains in a tertiary care university hospital. During the period of November 2012 – October 2013 we found 107 CPE (8.78%) out of 1219 non-duplicate Enterobacterales strains. 26 isolates of various Enterobacterales species carried blaNDM-1, 83 Klebsiella pneumoniae strains were positive for blaOXA-48-like and 2 of these co-harboured blaNDM-1. The increased incidence of OXA-48 producing K. pneumoniae was linked to a two-peaked hospital outbreak during February and May 2013. The percentage of 24.3% of NDM-1 producers was alarming due to the diversity of involved species and the higher resistance levels to carbapenems compared with blaOXA-48-like gene carriers. Plasmid replicon typing revealed a great diversity of plasmids in NDM-1-positive strains, belonging to incompatibility groups A/C, FII, FIIk, HI2, L and M. The strong connection between certain plasmid groups and host species suggests that the transfer of broad host-range plasmids through conjugation does not play the main role in the successful spread of blaNDM-1 among Enterobacterales species.
Caracterización y análisis del aprovechamiento de residuos vegetales generados en la central de abastos Merca-Neiva
Authors: Valderrama Lopez Christian Felipe , Férnandez Montealegre Adriana María , Duque Andrade Yineth 
Published: August 2020

La falta de gestión y educación ambiental dentro de las centrales de abastos de frutas y verduras en ciudades intermedias de Colombia, está generando volúmenes de residuos innecesarios que terminan dispuestos en rellenos sanitarios, desaprovechando su potencial de recuperación y reciclaje. El propósito de esta investigación fue determinar los factores que ocasionan los problemas en la separación y disposición de residuos, a partir de un estudio de caso dentro del establecimiento comercial de expendio de frutas y verduras más grande de la ciudad de Neiva – Colombia con un área de 80.049 m2. Para su desarrollo se determinó la periodicidad y frecuencia de recolección y transporte de los residuos a diario, se realizó una caracterización de estos y se aplicó una herramienta de recolección a 107 establecimientos. Se encontró un problema cultural, un 72% de la comunidad comerciante envejecida, un 54% de residuos orgánicos desaprovechados, 42% de otros residuos recuperables.
Revisión de la seguridad vial en la Av. 3E entre las calles 2N y 6N en la ciudad de Cúcuta para medir los riesgos a los que están expuestos los usuarios
Authors: Vega-Ortega Carolina , Medina-Gómez Daniela , Duarte Dairon 
Published: August 2020

La seguridad vial se considera hoy en día como un problema de gran importancia de salud pública en todo el mundo, ya que se ha obtenido un alto índice de accidentalidad y así mismo un alto índice de mortalidad, encaminados por la irresponsabilidad y la falta de cultura ciudadana en conductores y peatones. Por lo tanto, el presente artículo busca identificar y analizar el estado de la seguridad vial en un tramo de vía en la ciudad de Cúcuta Norte de Santander, ya que en esta zona han ocurrido muchos accidentes, esto se hace con el fin de cuantificar los riesgos a los que están expuestos los usuarios que a diario transitan esta vía. Para esta investigación, se maneja un enfoque cualitativo donde se recoge la información a partir de una encuesta virtual con una población de estudio de sesenta y cinco(65) personas que viven o frecuentan la av. 3e entre las calles 2n y 6n en la ciudad de Cúcuta Norte de Santander, para así determinar el grado de cultura ciudadana y otros aspectos, los resultados obtenidos hacen énfasis a que las personas de mayor edad son las que más están expuestas a los accidentes de tránsito, por tal razón se deben hacer capacitaciones he inculcar desde niños la cultura ciudadana con respecto a la seguridad vial.
ANALISIS PENGALURAN DALAM DRAMA I TOLOK KARYA RAHMAN ARGE
Authors: Hira Tauhid 
Published: August 2020

ABSTRAKDrama I Tolok mengisahkan tentang seorang pahlawan bagi rakyat miskin di tanah Makassar. I Tolok merupakan seorang perampok untuk rakyat miskin. Ia merampok orang-orang kaya yang hartanya berlebihan untuk diberikan kepada orang miskin dan tidak pernah meminta imbalan apa pun sehingga ia dikenal sebagai pahlawan bagi orang miskin. Penelitian terhadap drama I Tolok karya Rahman Arge akan difokuskan pada unsur pengaluran. Pengaluran sebagai salah satu unsur instrinstik dijadikan fokus penelitian pada drama tersebut karena rangkaian alur dan kompleksitas peristiwanya yang sangat menarik untuk dikaji lebih dalam. Selain itu, pembentukan dan alur cerita dalam naskah drama I Tolok juga sangat memengaruhi terhadap kedalaman karakter tokoh-tokoh dalam cerita. Setelah melakukan analisis dengan menggunakan pendekatan struktural terhadap pengaluran dalam drama I Tolok karya Rahman Arge menunjukkan bahwa jenis alur dalam drama I Tolok adalah alur sirkuler. Peristiwa-peristiwanya ditampilkan secara tidak berurutan dari awal cerita, tengah dan akhir cerita dan tema drama I Tolok karya Rahman Arge adalah setiap perbuatan dan tingkah laku manusia pasti memiliki resiko. Kata Kunci : Drama, I Tolok, Pengaluran, Alur Sirkuler, Tema
PENERAPAN AREA TRAFFIC CONTROL SYSTEM SEBAGAI IMPLEMENTASI TRANSPORTASI BERKELANJUTAN DI KOTA TEGAL
Authors: Rusmandani Pipit , Setiawan Riandy Sholeh 
Published: August 2020

Abstract The position of Tegal City in the North Coast Line (Pantura) of Central Java is very strategic, because it is the Hinterland for the surrounding area. This requires good conditions of roads and intersections. In this study, an attempt was made to apply coordinated signalized intersections, using the Area Traffic Control System, for 4 selected intersections. There are 3 alternatives proposed, namely Alternative I, which uses the Area Traffic Control System, Alternative II, which is autonomous control of intersections, and Alternative III, which does not need to coordinate the intersection. By using the Analytical Hierarchy Process method, respondents' support for Alternative I is 61.01%, for Alternative II is 27.19%, and for Alternative III is 12.12%. Keywords: intersection, signalized intersection, coordinated intersections, Area Traffic Control System Abstrak Posisi Kota Tegal yang berada di Jalur Pantai Utara (Pantura) Jawa Tengah sangat strategis, karena merupakan Hinterland bagi daerah di sekitarnya. Hal ini membutuhkan kondisi ruas jalan dan simpang yang baik. Pada studi ini dicoba untuk menerapkan simpang-simpang bersinyal yang terkoordinasi, dengan menggunakan Area Traffic Control System, pada 4 simpang yang dipilih. Terdapat 3 alternatif yang diusulkan, yaitu Alternatif I, yaitu menggunakan Area Traffic Control System, Alternatif II, yaitu pengendalian persimpangan secara otonom, dan Alternatif III, yaitu tidak perlu ada pengendalian persimpangan. Dengan menggunakan metode Analytical Hierarchy Process didapat dukungan responden untuk Alternatif I sebesar 61,01%, untuk Alternatif II sebesar 27,19%, dan untuk Alternatif III sebesar 12,16%. Kata-kata kunci: simpang, simpang bersinyal, pengendalian simpang, Area Traffic Control System
KINERJA MANAJEMEN LALU LINTAS BARU DI KAWASAN LOSARI KOTA MAKASSAR
Authors: Bau Qadriathi Dg , Ali Ichsan , Reski Nurul Tri Ayu 
Published: August 2020

Abstract The problem of urban traffic congestion is the main thing that always gets attention because congestion has a negative impact on the economy, the environment, and vehicle drivers. Makassar City is one of the cities experiencing traffic congestion on several existing roads, including roads in the Losari Area. Various efforts have been made by the government to reduce traffic congestion in the area, but optimum results have not been obtained. In 2019, a change in the direction of traffic movement in the Losari area was done by implementing a traffic management called the New Traffic Management. Through this new scheme, changes are made in the direction of movement of traffic on Jalan Penghibur, Jalan Haji Bau, and Jalan Lamadukelleng. This study aims to analyze the performance of the New Traffic Management towards improving traffic conditions in the Losari Area. The results of this study indicate that the application of New Traffic Management in the Losari Area has succeeded in improving traffic conditions in the area. Through this new traffic management scheme, the three road sections observed have service level A. Keywords: traffic congestion, traffic management, service level Abstrak Masalah kemacetan lalu lintas di perkotaan merupakan hal utama yang selalu mendapat perhatian karena kemacetan menimbulkan dampak negatif terhadap ekonomi, lingkungan, dan pengemudi kendaraan. Kota Makassar merupakan salah satu kota yang mengalami kemacetan lalu lintas di beberapa ruas jalan yang ada, termasuk jalan-jalan di kawasan Losari. Berbagai upaya telah dilakukan oleh pemerintah untuk mengurangi kemacetan lalu lintas di kawasan tersebut, tetapi belum diperoleh hasil yang optimum. Pada tahun 2019, dilakukan perubahan arah pergerakan lalu lintas di kawasan Losari dengan menerapkan suatu manajemen lalu lintas yang dinamakan Manajemen Lalu Lintas Baru atau New Traffic Management. Melalui skema yang baru ini dilakukan perubahan arah pergerakan lalu lintas di Jalan Penghibur, Jalan Haji Bau, dan Jalan Lamadu-kelleng. Penelitian ini bertujuan menganalisis kinerja Manajemen Lalu Lintas Baru ini terhadap perbaikan kondisi lalu lintas di kawasan Losari. Hasil studi ini menunjukkan bahwa penerapan Manajemen Lalu Lintas Baru di kawasan Losari berhasil memperbaiki kondisi lalu lintas di kawasan tersebut. Melalui skema manajemen lalu lintas yang baru ini, ketiga ruas jalan yang diamati mempunyai tingkat pelayanan A. Kata-kata kunci: kemacetan lalu lintas, manajemen lalu lintas, tingkat pelayanan