bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can PET/CT detect recurrence in post-operative colorectal carcinoma patients with elevated CEA level?
Authors: Ragheb Samar R. , Sharara Sherine M. 
Published: March 2020

Abstract
Background
PET is considered to be the most sensitive and specific modality for the detection of recurrent colorectal cancer. This study is to assess the role of F18-FDG PET/CT in post-operative assessment in a patient with colorectal cancer with elevated CEA level to rule out local recurrence and/or metastasis and hence guiding the clinician to the proper management strategy.

Results
This study was performed on 45 patients who underwent surgical resection of the colon and/or rectal cancer; they were referred for PET/CT assessment at least 3 months after surgical resection. F18-FDG PET/CT sensitivity and specificity in detecting the recurrence and/or metastasis were 96.9 % and 83.3%, respectively. The positive predictive value was 94.2% while the negative predictive value was 90%.

Conclusion
For post-operative detection of loco-regional recurrence and metastasis in patients with colorectal cancer and elevated CEA level, 18F-FDG PET/CT can be considered as an efficient diagnostic imaging tool due to its high sensitivity and specificity which extensively affect further management.
SlicerDMRI: Diffusion MRI and Tractography Research Software for Brain Cancer Surgery Planning and Visualization
Authors: Zhang Fan , Noh Thomas , Juvekar Parikshit , Frisken Sarah F. , Rigolo Laura , Norton Isaiah , Kapur Tina , Pujol Sonia , Wells William , Yarmarkovich Alex , Kindlmann Gordon , Wassermann Demian , San Jose Estepar Raul , Rathi Yogesh , Kikinis Ron , Johnson Hans J. , Westin Carl-Fredrik , Pieper Steve , Golby Alexandra J. , O’Donnell Lauren J. 
Published: March 2020

PURPOSE We present SlicerDMRI, an open-source software suite that enables research using diffusion magnetic resonance imaging (dMRI), the only modality that can map the white matter connections of the living human brain. SlicerDMRI enables analysis and visualization of dMRI data and is aimed at the needs of clinical research users. SlicerDMRI is built upon and deeply integrated with 3D Slicer, a National Institutes of Health–supported open-source platform for medical image informatics, image processing, and three-dimensional visualization. Integration with 3D Slicer provides many features of interest to cancer researchers, such as real-time integration with neuronavigation equipment, intraoperative imaging modalities, and multimodal data fusion. One key application of SlicerDMRI is in neurosurgery research, where brain mapping using dMRI can provide patient-specific maps of critical brain connections as well as insight into the tissue microstructure that surrounds brain tumors. PATIENTS AND METHODS In this article, we focus on a demonstration of SlicerDMRI as an informatics tool to enable end-to-end dMRI analyses in two retrospective imaging data sets from patients with high-grade glioma. Analyses demonstrated here include conventional diffusion tensor analysis, advanced multifiber tractography, automated identification of critical fiber tracts, and integration of multimodal imagery with dMRI. RESULTS We illustrate the ability of SlicerDMRI to perform both conventional and advanced dMRI analyses as well as to enable multimodal image analysis and visualization. We provide an overview of the clinical rationale for each analysis along with pointers to the SlicerDMRI tools used in each. CONCLUSION SlicerDMRI provides open-source and clinician-accessible research software tools for dMRI analysis. SlicerDMRI is available for easy automated installation through the 3D Slicer Extension Manager.
Circulating Tumor DNA Predicts the Response and Prognosis in Patients With Early Breast Cancer Receiving Neoadjuvant Chemotherapy
Authors: Li Shunying , Lai Hongna , Liu Jieqiong , Liu Yujie , Jin Liang , Li Yudong , Liu Fengtao , Gong Yuhua , Guan Yanfang , Yi Xin , Shi Qianfeng , Cai Zijie , Li Qian , Li Ying , Zhu Mengdi , Wang Jingru , Yang Yaping , Wei Wei , Yin Dong , Song Erwei , Liu Qiang 
Published: March 2020

PURPOSE Many patients with breast cancer still relapse after curative treatment. How to identify the ones with high relapse risk remains a critical problem. Circulating tumor DNA (ctDNA) has recently become a promising marker to monitor tumor burden. Whether ctDNA can be used to predict the response and prognosis in patients with breast cancer receiving neoadjuvant chemotherapy (NAC) is unknown. Our study aimed to evaluate the clinical value of the presence and dynamic change of ctDNA to predict the tumor response and prognosis in patients with breast cancer treated with NAC. MATERIALS AND METHODS Fifty-two patients with early breast cancer who underwent NAC were prospectively enrolled. Serial plasma samples before, during, and after NAC and paired tumor biopsies were harvested and subjected to deep targeted sequencing using a large next-generation sequencing panel that covers 1,021 cancer-related genes. RESULTS Positive baseline ctDNA was detected in 21 of 44 patients before NAC. Most patients with positive ctDNA had one or more mutations confirmed in paired primary tumor. The ctDNA level after 2 cycles of NAC was predictive of local tumor response after all cycles of NAC (area under the curve, 0.81; 95% CI, 0.61 to 1.00). ctDNA tracking during NAC outperformed imaging in predicting the overall response to NAC. More importantly, positive baseline ctDNA is significantly associated with worse disease-free survival ( P = .011) and overall survival ( P = .004) in patients with early breast cancer, especially in estrogen receptor–negative patients. CONCLUSION Our study demonstrated that ctDNA can be used to predict tumor response to NAC and prognosis in early breast cancer, providing information to tailor an individual’s therapeutic regimen.
Genetic Variation atPPP1R3BIncreases Hepatic CT Attenuation and Interacts With Prandial Status on Plasma Glucose
Authors: Seidelin Anne-Sofie , Nordestgaard Børge Grønne , Tybjærg-Hansen Anne , Stender Stefan 
Published: March 2020

AbstractContextA common genetic variant near PPP1R3B (rs4841132G &gt; A) has been associated with increased hepatic computed tomography (CT) attenuation and with plasma levels of glucose and liver enzymes.ObjectiveTo elucidate the association of rs4841132 with hepatic CT attenuation, and to test if synergistic effects modify the association of the variant with plasma glucose and liver enzymes.DesignPopulation-based cohort study.Setting and ParticipantsThe Copenhagen City Heart Study and the Copenhagen General Population Study combined, totaling 107 192 individuals from the Danish general population. Hepatic CT scans were available in 6445 individuals.Main Outcome MeasuresHepatic CT attenuation and plasma levels of glucose and liver enzymes.ResultsThe rs4841132 A-allele (rs4841132-A) was associated with higher hepatic CT attenuation (P = 5 × 10−6). The probability of carrying rs4841132-A increased with higher hepatic CT attenuation in the range above 65 Hounsfield units, but remained constant at the range below (P = 4 × 10−8 for nonlinearity). Rs4841132-A was associated with up to 0.17 mmol/L higher plasma glucose in fasting individuals, but with up to 0.17 mmol/L lower glucose in postprandial individuals (P = 6 × 10−5 for interaction between rs4841132 and time since last meal on plasma glucose). Finally, rs4841132-A was associated with up to 2 U/L higher plasma alanine transaminase (P = 3 × 10−6). This association was not modified by adiposity, alcohol intake, or steatogenic genetic risk.ConclusionsRs4841132-A associates with higher hepatic CT attenuation in a distinctly nonlinear manner, and its association with plasma glucose depends on prandial status. The overall association pattern supports that rs4841132-A promotes hepatic glycogen synthesis postprandially.
“The Desire to Banish Any Constraint in Clothing”
Authors: Van Cleave Kendra 
Published: March 2020

AbstractLed by Jean-Jacques Rousseau, Enlightenment concerns about the negative consequences of luxury and artifice, as well as clothing's physical and moral effects, meant that by the late eighteenth century naturalism, simplicity, comfort, health, and morality had become the bywords of dress. In the newly invented French fashion press, editors adopted philosophes' arguments to resolve potential conflicts between consumption and Enlightenment ideas. However, they did so primarily with Ottoman-inspired French fashions rather than with the English styles that have thus far been the primary scholarly concern. Turquerie—Turkish-focused Orientalism—allowed the creators of these magazines to connect fashion to Enlightenment principles while reinforcing consumption through more subtle promotions of luxury; moreover, unlike the democratically linked English-inspired styles that followed, turquerie did not challenge France's autocratic monarchy.Dans la seconde moitié du dix-huitième siècle, le mouvement des Lumières a eu des effets considérables sur la culture française, notamment sur l'habillement et l'apparence. Soulevées par le philosophe Jean-Jacques Rousseau, les préoccupations des Lumières au sujet des méfaits du luxe et de l'artifice, ainsi que les conséquences physiques et morales du port du vêtement, ont fait du naturalisme, de la simplicité, du confort, de la santé et de la moralité les maîtres mots du vêtement à la fin du dix-huitième siècle. Dans la presse de mode française, nouvellement créée, les éditeurs adoptèrent les arguments des philosophes afin de résoudre les conflits potentiels entre la consommation et les idées des Lumières. Cependant, ils le firent principalement à travers la promotion des modes françaises d'inspiration ottomane, plutôt qu'avec les styles anglais qui jusque-là ont fait l'objet de nombreuses études. La turquerie—l'orientalisme turc—permit en effet aux éditeurs des journaux de réconcilier la mode avec les principes des Lumières tout en renforçant l'incitation à la consommation via la promotion du luxe par des moyens plus subtils. Contrairement aux styles d'inspiration anglaise liés à la démocratie qui s'en suivirent, la turquerie ne remettait pas en cause la monarchie autocratique française.
Dressing the Eiffel Tower
Authors: Stempniak Kasia 
Published: March 2020

Abstract
The construction of the Eiffel Tower for the 1889 Universal Exposition sparked “Eiffelomania,” a craze for objects imprinted with the likeness of the tower. This mania reverberated in the fashion world, with journals touting the latest fabrics, colors, and styles named “Eiffel.” But the tower's association with fashion went beyond the materiality of clothing. Careful examination of news reports and fashion chronicles from the fin de siècle period reveals that the tower was frequently cast in sartorial terms. In describing the tower's manner of “dressing,” its “clothing” and “outfits,” these discourses brought to the fore the shared theoretical bonds between fashion and architecture. This article traces the reception of the Eiffel Tower in fin de siècle Paris and argues that the sartorial imagery associated with the tower conceptualizes architecture as a form of fashion.
La construction de la Tour Eiffel à l'occasion de l'Exposition universelle de 1889 a déclenché l' « Eiffelomanie », un engouement pour toute une série d'objets réalisés à l'effigie de la Tour Eiffel. Cette obsession a eu des échos jusque dans le monde de la mode grâce aux journaux de mode qui promouvaient des étoffes, des couleurs, et des styles à la « Eiffel ». Mais l'association de la Tour Eiffel et de la mode ne s'est pas limitée à la matérialité des vêtements. Une analyse attentive des chroniques de mode démontre que la Tour Eiffel était souvent évoquée à travers des termes empruntés au lexique vestimentaire. En décrivant « l'habillement » de la Tour Eiffel, ses « robes » ou ses « toilettes », ces discours mettaient en évidence les liens théoriques que partagaient la mode et l'architecture. Cet article s'intéresse à la réception que la Tour Eiffel a eue dans le Paris fin-de-siècle, et soutient l'idée selon laquelle le champ lexical vestimentaire associé à la Tour Eiffel conceptualisait l'architecture comme une forme de la mode.
Diagnostic efficacy of contrast-enhanced ultrasound for breast lesions of different sizes: a comparative study with magnetic resonance imaging
Authors: Li Chunxiao , Yao Minghua , Shao Sihui , Li Xin , Li Gang , Wu Rong 
Published: March 2020

Objective:
This study aimed to compare the diagnostic performance of contrast-enhanced ultrasound (CEUS), MRI, and the combined use of the two modalities for differentiating breast lesions of different sizes.

Methods:
A total of 406 patients with 406 solid breast masses detected by conventional ultrasound underwent both CEUS and MRI scans. Histological results were used as reference standards. The lesions were categorized into three groups according to size (Group 1, ≤ 20 mm; Group 2, &gt; 20 mm, Group 3: total lesions). Sensitivity, specificity, accuracy, and receiver operating characteristic (ROC) curve analysis were used to assess the diagnostic performance of these imaging methods for breast lesions.

Results:
There were 194 benign and 212 malignant breast lesions according to the histological diagnosis. Compared with MRI, CEUS demonstrated similar sensitivity in detecting breast cancer (p = 1.0000 for all) in all the three groups. With regard to specificity, accuracy, and the area under the ROC curve (Az) values, MRI showed a better performance than that shown by CEUS (p ＜0.05 for all), and the combination of the two modalities improved the diagnostic performance of CEUS alone significantly (p ＜0.05 for all) in all the three groups. However, the diagnostic specificity and accuracy of the combined method was not superior to that of MRI alone except for Group 2.

Conclusion:
CEUS demonstrated good sensitivity in detecting breast cancer, and the combined use with MRI can optimize the diagnostic specificity and accuracy in breast cancer prediction.

Advances in knowledge:
Few studies have compared the diagnostic efficacy of CEUS and MRI, and this study is the first attempt to seek out the diagnostic values for breast lesions of variable sizes (lesions with ≤20 mm and &gt;20 mm).
Demonstration of carpet cloaking by an anisotropic zero refractive index medium
Authors: Bor Emre , Gorkem Yasa Utku , Kurt Hamza , Turduev Mırbek 
Published: March 2020

In this Letter, we numerically and experimentally demonstrate the carpet cloaking effect by a rectangular lattice two-dimensional photonic crystal (PC) exhibiting a semi-Dirac cone (SDC) dispersion phenomenon. The proposed SDC PC with an anisotropic zero refractive index medium operates as an optical carpet cloak for a perfect electric conductor surface bump. The experimental verification of the cloak is realized at microwave frequencies at around 12.1 GHz via dielectric rods. A good agreement between experimental measurements and numerical calculations is observed. Finally, features such as rendering larger objects invisible are possible with the proposed idea.
So, who is responsible? A framing analysis of newspaper coverage of electoral violence in Zimbabwe
Authors: Munoriyarwa Allen 
Published: March 2020

Abstract
This study examines how the 2008 election violence was framed in three mainstream Zimbabwean weekly newspapers – The Sunday Mail, The Independent and The Zimbabwean. It was noted that four frames – the victim, justice and human rights, trivialization and attribution of responsibility frames dominated the coverage of electoral violence in these three newspapers. The dominance of the trivializing frame in The Sunday Mail privileged the ruling party’s (Zimbabwe African National Union Patriotic Front; ZANU PF) interpretation of electoral violence as inconsequential to the electoral process. Simultaneously, the prevalence of the victim, justice and human rights frames in The Independent and The Zimbabwean newspapers signifies the private media’s obsession with ZANU PF’s alleged electoral malpractices and situates these alleged transgressions within a broad global social justice and human rights trajectory to cultivate the West’s sympathy with the ‘victimised’ opposition.
TORNAR-SE CIENTISTA: NARRATIVAS DE MULHERES PESQUISADORAS NO CONTINENTE ANTÁRTICO
Authors: R. Almeida Maria Rozana , Costa Ribeiro Paula Regina , Machado Vilaça Maria Teresa 
Published: March 2020

O presente artigo tem, como foco, analisar as dificuldades e os obstáculos encontrados nas narrativas de mulheres cientistas, em um ambiente inóspito, de difícil acesso e majoritariamente masculino, como o Continente Antártico. Por meio de entrevistas semiestruturadas, o estudo busca dar visibilidade às narrativas de três pesquisadoras coordenadoras e de cinco pesquisadoras alunas, com experiências em embarques, estação e/ou acampamentos, nas quais é possível perceber que, nas relações de gênero, a partir de uma materialidade biológica, discursos são construídos, em função de atributos ditos masculinos ou femininos. Tais discursos indicam as atividades que podem ou não ser executadas por mulheres cientistas, emergindo, nos enunciados, aspectos que configuram discriminações, preconceitos velados como cuidados, o “funil” maternidade e o modo “feminino” de fazer ciência.PALAVRAS-CHAVE: Relações de gênero. Antártica. Ciência.
A Study on Fatigue Behaviors of Concrete under Uniaxial Compression: Testing, Analysis, and Simulation
Authors: Fan Ziyuan , Sun Yongming 
Published: March 2020

Abstract
The fatigue damage of concrete is an important reason for cracking and failure. To comprehensively study fatigue behaviors of concrete under uniaxial compression, cylindrical specimens with two different strength levels were made for cyclic loading tests. The evolution of fatigue process was detected via sensors, strain gages, and an X-ray computed tomography (CT) scanner. Parameters of fatigue life, deformation, internal cracks, and strength under different stress levels are analyzed based on measurements. The stress-cyclic number (S-N) equation is also given. Then, the fatigue damage parameter D is used to evaluate the status of damage. Additionally, a finite element modeling approach is developed based on the CT images to simulate the evolution of fatigue cracks within concrete specimens. With results of both macroscopic and microscopic analysis, the fatigue failure mechanism of concrete is expounded. The analysis results of this paper can provide a basis for the safety assessment for concrete structures.
Pasireotide for acromegaly: long-term outcomes from an extension to the Phase III PAOLA study
Authors: Colao Annamaria , Bronstein Marcello D , Brue Thierry , De Marinis Laura , Fleseriu Maria , Guitelman Mirtha , Raverot Gerald , Shimon Ilan , Fleck Jürgen , Gupta Pritam , Pedroncelli Alberto M , Gadelha Mônica R 
Published: March 2020

Objective
In the Phase III PAOLA study (clinicaltrials.gov: NCT01137682), enrolled patients had uncontrolled acromegaly despite ≥6 months of octreotide/lanreotide treatment before study start. More patients achieved biochemical control with long-acting pasireotide versus continued treatment with octreotide/lanreotide (active control) at month 6. The current work assessed the extent of comorbidities at baseline and outcomes during a long-term extension.

Design/methods
Patients receiving pasireotide 40 or 60 mg at core study end could continue on the same dose in an extension phase if biochemically controlled or receive pasireotide 60 mg if uncontrolled. Uncontrolled patients on active control were switched to pasireotide 40 mg, with the dose increased at week 16 of the extension if still uncontrolled (crossover group). Efficacy and safety are reported to 304 weeks (~5.8 years) for patients randomized to pasireotide (core + extension), and 268 weeks for patients in the crossover group (extension only).

Results
Almost half (49.5%; 98/198) of patients had ≥3 comorbidities at core baseline. During the extension, 173 patients received pasireotide. Pasireotide effectively and consistently reduced GH and IGF-I levels for up to 5.8 years’ treatment; 37.0% of patients achieved GH <1.0 µg/L and normal IGF-I at some point during the core or extension. Improvements were observed in key symptoms. The long-term safety profile was similar to that in the core study; 23/173 patients discontinued treatment because of adverse events.

Conclusions
In this patient population with a high burden of comorbid illness, pasireotide was well tolerated and efficacious, providing prolonged maintenance of biochemical control and improving symptoms.
Anchor Away – A Fast, Reliable and Reversible Technique To Inhibit Proteins inDrosophila melanogaster
Authors: Bosch Pablo Sanchez , Pepperl Julia , Basler Konrad 
Published: March 2020

AbstractSeveral techniques have been developed to study specific gene function in loss-of-function situations. In Drosophila melanogaster, RNAi and the generation of mutant clones are widely used. However, both techniques have the limitation that there is a significant time lag before gene function is abolished. Given the relatively rapid development of Drosophila, such perdurance is a serious impediment to study gene function. Here we describe the adaptation of the anchor-away technique for use in Drosophila. Anchor-away was originally developed in yeast to quickly and efficiently abrogate the function of nuclear proteins by sequestering - anchoring - them away in a different cellular compartment. The required components are present in the cells, and the system is triggered by the addition of rapamycin, resulting in a rapid generation of a loss-of-function situation. We provide here proof of principle for the system by producing loss-of-function situations for two nuclear proteins – Pygopus and Brinker. The system allows to study the requirement of any protein during any time window, and at the same time circumvents difficulties, such as off-target effects or variable phenotypes, which are inherent in other techniques, for example RNAi.
Aglomeraciones industriales locales vis-à-vis redes competitivas globales: nociones marshallianas de zonas económicas, innovación y desarrollo territorial
Authors: Ugalde Hernández Oscar 
Published: March 2020

Innovación es una contribución importante que las áreas industriales (clusters) hacen en relación al desarrollo territorial. Esta revisión literaria post-Marshalliana analiza la noción de innovación, y explica su evolución en el contexto de las teorías recientes, que abordan los clusters, y el desarrollo territorial.
Desde 1990, y hasta las contribuciones teóricas más recientes, éste estudio analiza la innovación, particularmente en relación a los clusters, y cómo pueden contribuir al desarrollo y la competitividad de las de los territorios y los países. El modelo de Diamante de Porter y sus extensiones teóricas, enfocadas en demanda y determinantes de factores y de mercado, son catalizadores intelectuales de la noción de innovación en relación al desarrollo territorial. Sin embargo, éste estudio denota que su ambigüedad y su flexibilidad ha hecho que escritores franceses post-Porterianos consideren que espacialidad y relacionalidad a través de redes, sectores e industrias, son esenciales para generar innovación y la creación de conocimiento, y su respectiva difusión. Además, los enfoques de Economía Política, tales como los modelos de innovación de las hélices y el análisis semiótico inspirado en Marxismo, han estimulado el uso de innovación como un factor de cambio, el cual influencia los territorios y las naciones.
Conforme la innovación se incorporar en los modelos estudiados, su contribución se hace cada vez más evidente. El común denominador entre todas las teorías post-Marshallianas es el papel cambiante y crucial que innovación juega como catalizador de competitividad y desarrollo en las zonas francas, y a nivel territorial, nacional y global.