bluuebunny/crossref_metadata_2025_split huggingface dataset:
A natriuretic peptide from Arabidopsis thaliana (AtPNP-A) can modulate catalase 2 activity
Authors: Turek Ilona , Wheeler Janet , Bartels Sebastian , Szczurek Jolanta , Wang Yu Hua , Taylor Phil , Gehring Chris , Irving Helen 
Published: November 2020

AbstractAnalogues of vertebrate natriuretic peptides (NPs) present in plants, termed plant natriuretic peptides (PNPs), comprise a novel class of hormones that systemically affect salt and water balance and responses to plant pathogens. Several lines of evidence indicate that Arabidopsis thaliana PNP (AtPNP-A) affects cellular redox homeostasis, which is also typical for the signaling of its vertebrate analogues, but the molecular mechanism(s) of this effect remains elusive. Here we report identification of catalase 2 (CAT2), an antioxidant enzyme, as an interactor of AtPNP-A. The full-length AtPNP-A recombinant protein and the biologically active fragment of AtPNP-A bind specifically to CAT2 in surface plasmon resonance (SPR) analyses, while a biologically inactive scrambled peptide does not. In vivo bimolecular fluorescence complementation (BiFC) showed that CAT2 interacts with AtPNP-A in chloroplasts. Furthermore, CAT2 activity is lower in homozygous atpnp-a knockdown compared with wild type plants, and atpnp-a knockdown plants phenocopy CAT2-deficient plants in their sensitivity to elevated H2O2, which is consistent with a direct modulatory effect of the PNP on the activity of CAT2 and hence H2O2 homeostasis. Our work underlines the critical role of AtPNP-A in modulating the activity of CAT2 and highlights a mechanism of fine-tuning plant responses to adverse conditions by PNPs.
Artificial whole genome duplication in paleopolyploid sturgeons yields highest documented chromosome number in vertebrates
Authors: Lebeda Ievgen , Ráb Petr , Majtánová Zuzana , Flajšhans Martin 
Published: November 2020

AbstractCritically endangered sturgeons, having undergone three whole genome duplication events, represent an exceptional example of ploidy plasticity in vertebrates. Three extant ploidy groups, combined with autopolyploidization, interspecific hybridization and the fertility of hybrids are important issues in sturgeon conservation and aquaculture. Here we demonstrate that the sturgeon genome can undergo numerous alterations of ploidy without severe physiological consequences, producing progeny with a range of ploidy levels and extremely high chromosome numbers. Artificial suppression of the first mitotic division alone, or in combination with suppression of the second meiotic division of functionally tetraploid zygotes (4n, C-value = 4.15) of Siberian sturgeon Acipenser baerii and Russian sturgeon A. gueldenstaedtii resulted in progeny of various ploidy levels—diploid/hexaploid (2n/6n) mosaics, hexaploid, octoploid juveniles (8n), and dodecaploid (12n) larvae. Counts between 477 to 520 chromosomes in octoploid juveniles of both sturgeons confirmed the modal chromosome numbers of parental species had been doubled. This exceeds the highest previously documented chromosome count among vertebrates 2n ~ 446 in the cyprinid fish Ptychobarbus dipogon.
Better continuity of care improves the quality of end-of-life care among elderly patients with end-stage renal disease
Authors: Chen Annie Y. , Chen Bradley , Kuo Chin-Chi 
Published: November 2020

AbstractContinuity of care (COC) has been emphasized in research on terminal cancer patients to increase the quality of end-of-life care; however, limited research has been conducted on end-stage renal disease patients. We applied a retrospective cohort design on 29,095 elderly patients with end-stage renal disease who died between 2005 and 2013. These patients were identified from the National Health Insurance Research Database of Taiwan. The provider Continuity of Care Index (COCI) and site COCI were calculated on the basis of outpatient visits during the 6–12 months before death. We discovered that increases in the provider COCI were significantly associated with reductions in health expenditures after adjusting for confounders, especially in inpatient and emergency departments, where the treatment intensity is high. Higher provider and site COC were also associated with lower utilization of acute care and invasive treatments in the last month before death. Provider COC had a greater effect on end-of-life care expenditures than site COC did, which indicated significant care coordination gaps within the same facility. Our findings support the recommendation of prioritizing the continuity of end-of-life care, especially provider continuity, for patients with end-stage renal disease.
Identifying potential biomarkers related to pre-term delivery by proteomic analysis of amniotic fluid
Authors: Hong Subeen , Lee Ji Eun , Kim Yu Mi , Park Yehyon , Choi Ji-Woong , Park Kyo Hoon 
Published: November 2020

AbstractWe sought to identify biomarkers in the amniotic fluid (AF) and specific signaling pathways related to spontaneous preterm delivery (SPTD, < 34 weeks) in women with preterm labor (PTL) without intra-uterine infection/inflammation (IUI). This was a retrospective cohort study of a total of 139 PTL women with singleton gestation (24 + 0 to 32 + 6 weeks) who underwent amniocentesis and who displayed no evidence of IUI. A nested case–control was conducted using pooled AF samples (n = 20) analyzed via label-free liquid chromatography-tandem mass spectrometry. In the total cohort, an ELISA validation study was performed for seven candidate proteins of interest. Proteomic analysis identified 77 differentially expressed proteins (DEPs, P < 0.05) in the AF from SPTD cases compared to term delivery controls. ELISA validation confirmed that women who had an SPTD before 34 weeks had significantly independently lower levels of VEGFR-1 and higher levels of lipocalin-2 and the Fc fragment of IgG binding protein in the AF. Five principle pathways associated with the 77 DEPs were identified, including glycolysis, gluconeogenesis, and iron homeostasis. The proteomic analysis data of AFs from women with PTL identified several novel biomarkers and specific protein pathways related to SPTD in the absence of IUI.
Transitions from One Electronic Health Record to Another: Challenges, Pitfalls, and Recommendations
Authors: Huang Chunya , Koppel Ross , McGreevey John D. , Craven Catherine K. , Schreiber Richard 
Published: November 2020

Abstract
Objective We address the challenges of transitioning from one electronic health record (EHR) to another—a near ubiquitous phenomenon in health care. We offer mitigating strategies to reduce unintended consequences, maximize patient safety, and enhance health care delivery.
Methods We searched PubMed and other sources to identify articles describing EHR-to-EHR transitions. We combined these references with the authors' extensive experience to construct a conceptual schema and to offer recommendations to facilitate transitions.
Results Our PubMed query retrieved 1,351 citations: 43 were relevant for full paper review and 18 met the inclusion criterion of focus on EHR-to-EHR transitions. An additional PubMed search yielded 1,014 citations, for which we reviewed 74 full papers and included 5. We supplemented with additional citations for a total of 70 cited. We distinguished 10 domains in the literature that overlap yet present unique and salient opportunities for successful transitions and for problem mitigation.
Discussion There is scant literature concerning EHR-to-EHR transitions. Identified challenges include financial burdens, personnel resources, patient safety threats from limited access to legacy records, data integrity during migration, cybersecurity, and semantic interoperability. Transition teams must overcome inadequate human infrastructure, technical challenges, security gaps, unrealistic providers' expectations, workflow changes, and insufficient training and support—all factors affecting potential clinician burnout.
Conclusion EHR transitions are remarkably expensive, laborious, personnel devouring, and time consuming. The paucity of references in comparison to the topic's salience reinforces the necessity for this type of review and analysis. Prudent planning may streamline EHR transitions and reduce expenses. Mitigating strategies, such as preservation of legacy data, managing expectations, and hiring short-term specialty consultants can overcome some of the greatest hurdles. A new medical subject headings (MeSH) term for EHR transitions would facilitate further research on this topic.
Subcategorization frame identification for learner English
Authors: Huang Yan , Murakami Akira , Alexopoulou Theodora , Korhonen Anna 
Published: November 2020

Abstract
As large-scale learner corpora become increasingly available, it is vital that natural language processing (NLP)
technology is developed to provide rich linguistic annotations necessary for second language (L2) research. We present a system for
automatically analyzing subcategorization frames (SCFs) for learner English. SCFs link lexis with morphosyntax, shedding light on the
interplay between lexical and structural information in learner language. Meanwhile, SCFs are crucial to the study of a wide range of
phenomena including individual verbs, verb classes and varying syntactic structures. To illustrate the usefulness of our system for learner
corpus research and second language acquisition (SLA), we investigate how L2 learners diversify their use of SCFs in text and how this
diversity changes with L2 proficiency.
Optimizing the electric field strength in multiple targets for multichannel transcranial electric stimulation
Authors: Saturnino Guilherme B , Madsen Kristoffer H , Thielscher Axel 
Published: November 2020

Abstract

Objective. Most approaches to optimize the electric field pattern generated by multichannel transcranial electric stimulation (TES) require the definition of a preferred direction of the electric field in the target region(s). However, this requires knowledge about how the neural effects depend on the field direction, which is not always available. Thus, it can be preferential to optimize the field strength in the target(s), irrespective of the field direction. However, this results in a more complex optimization problem. Approach. We introduce and validate a novel optimization algorithm that maximizes focality while controlling the electric field strength in the target to maintain a defined value. It obeys the safety constraints, allows limiting the number of active electrodes and allows also for multi-target optimization. Main results. The optimization algorithm outperformed naïve search approaches in both quality of the solution and computational efficiency. Using the amygdala as test case, we show that it allows for reaching a reasonable trade-off between focality and field strength in the target. In contrast, simply maximizing the field strength in the target results in far more extended fields. In addition, by maintaining the pre-defined field strengths in the targets, the new algorithm allows for a balanced stimulation of two or more regions. Significance. The novel algorithm can be used to automatically obtain individualized, optimal montages for targeting regions without the need to define preferential directions. It will automatically select the field direction that achieves the desired field strength in the target(s) with the most focal stimulation pattern.
Sensitivity analysis of factors influencing pillar stability in the deep stope of underground salt mine
Authors: Qin X S , Cao H , Guo L J 
Published: November 2020

Abstract
The orebody and the surrounding rock of underground salt mine are generally divided into soft rock or extremely soft rock. In these mines, the strip room pillar method is primarily used. Continuous pillars with a certain width are left between every two mining strips. These pillars are used to provide support to the overlying surrounding rock. However, the stability of the pillars restricts the stope structural parameters of the mining method. Thus, it is important to first determine the main factors that affect pillar stability and analyze the influence level of these factors. Using a deep mining underground salt mine as an example, the characteristics of pillar instability and the pillar load are analyzed. The safety factor of the pillar refers to the ratio of pillar strength to pillar load, which can be used to quantitatively evaluate pillar stability. Based on the formula of pillar stress and the empirical formula of pillar strength, the formula of the pillar safety factor is deduced. Based on this formula, the primary factors affecting pillar stability are comprehensively analyzed. Moreover, the sensitivities of these factors are compared and analyzed based on the orthogonal range theory. According to the calculation results of the range, the factors influencing pillar stability in the underground salt mine are the mining depth and uniaxial compressive strength of ore, which are the most significant factors, followed by the height and width of pillars, and then the room width and unit weight of the overlying strata, which have relatively small influence. The safety factor of the pillar is positively correlated with the pillar width and uniaxial compressive strength but negatively correlated with the mining depth, pillar height, room width, and the unit weight of the overlying strata. The specific reasons of each factor affecting the safety coefficient are analyzed in detail. The changing trend of the pillar safety factor with various influencing factors can provide an important basis for the optimal design of stope structural parameters and the determination of support scheme.
Cause Analysis and Treatment Measures of Tunnel Diseases in Complex Geological Structure with Gypsum-bearing Rock Layers
Authors: Song Chaoye , He Weiguo , Wang Hanchen , Wu Weihao 
Published: November 2020

Abstract
The length of NL Tunnel in North China is 23.4 km. The ballast bed of the tunnel is a heavy-haul and double-block, ballast-less track. After being completed and opened to traffic, serious diseases such as concrete corrosion, cracking of the lining, deformation of the side wall, and uplift of the track bed were observed. The cumulative length of the disease-carrying tunnel, ~1.4 km, negatively affects the safety of motorists. On-site investigation, theoretical analysis, experimental testing, and numerical calculations, revealed that tunnel diseases result from various factors. That is, owing to the complex geological structure, changes in the volume and quality of groundwater in the gypsum-bearing rock layer were accompanied by special low-temperature sulfate corrosion, rare differential expansion, and significant water-sensitive softening with rheological characteristics. These phenomena eventually resulted in tunnel diseases. Through stability analysis and field practice, an effective set of measures was adopted. These measures included a support structure system combined with near-circular cross sections and buffer layers, a new type of drainage system with special rock layers from inside to outside, and lining structural materials with low-temperature sulfate resistance.
A rock self-supporting high conductivity acid fracturing technique in a deep carbonate reservoir
Authors: Baoping Lu , Zhou Jun , Jiang Tingxue , Ding Shidong , Zhou Linbo , Deng Dawei , Zhou Jian 
Published: November 2020

Abstract
As carbonate reservoirs in deeper strata continue to develop, reservoir closure stress has significantly increased, where conventional acid fracturing technology cannot maintain acid-etched fracture conductivity and single well production rates are decreasing more quickly. This study proposes a rock self-supporting, highly conductive acid fracturing technique, where the shielding materials cover a portion of the primary hydraulic fracture surface to block the acid rock reaction. After acid injection, the unetched part will be a bearing surface, which serves as a large area and self-supporting high strength rock. This technique fundamentally changes the existing point support pattern of acid-etched fractures. Experimental results demonstrate that when the closed stress is <50 MPa, the self-supporting conductivity is 42% higher than the conventionally acid etched fractures. At 90 MPa closed stress, it can still maintain high support strength, which is more than eight times that of a conventional acid etched fracture. The equilibrium relationship between the fracture conductivity and rock support strength was determined using finite element stress simulation and fluid mechanics simulation. The results demonstrate that using a small cylindrical area, dislocation support, and multi-point support is conducive to the dispersion of high closure stress; moreover, the concentrated stress intensity of supporting rock can be reduced by 3–12 MPa. With decrease in supporting area, the stress intensity of the supporting rock is higher. Considering the compressive strength of the rock, the supporting area is >25%. When the rock is in the form of a dislocation support, the fluid disperses in the larger void channels, thus effectively maintaining fracture conductivity. The self-supporting acid fracturing technique is useful for increasing the utility of acid fracturing stimulation in deep and ultra-deep wells.
Failure Mechanisms and Mitigation Measures of the G1006 Electricity Pylon Landslide in the Dam Area of the Jinping I Hydropower Station
Authors: Yang Y X , Luo G , Duan Y Y , Zhang C Z , Zhang Y G , Lei Q 
Published: November 2020

Abstract
On the 29th and 30th of August 2012, more than 100 geological disasters occurred near the dam area of Jinping I Hydropower Station, Xichang, China due to local intense rainstorm. The upper part of the left valley slope, which is 500 m upstream of the dam, failed and slid, exposing the C-pile of the G1006 electricity pylon and threatening the entire power transmission lines. Therefore, ensuring the stability of the residual rock masses in the rear of the main scarp and the safety of the G1006 electricity pylon became a primary emergency task. Field geological survey, topographic mapping, and the instability mechanism study of the G1006 electricity pylon landslide were conducted. Results revealed that the G1006 electricity pylon landslide (here after represented as the G1006 EPL) occurred in the middle block cut by two faults, and the rock masses had inferior mechanical properties. Intense unloading effects and frequent microseism events during the dam construction relaxed the rock mass structural planes and reduced the geotechnical parameters. Under the influence of intense rainfall, the failure mechanisms of the slope were a combination of slope surface effect from rainfall and lateral erosion and undercutting of the slope toe by high flooding. The residual rock masses and landslide deposits around the pylon foundation were unstable under natural conditions and during the rainstorm. To prevent the continuous damage and exposure of C-pile foundation and ensure the stability of pylon foundation, the mitigation measure of “retaining piles + platform + retaining wall” was arranged. Moreover, a check dam was added to stabilize the slope toe and prevent the landslide deposits, which are the starting material source of debris flow that threatens the safety of the arch dam.
Grouting Reinforcement Technology of Weak Fractured Rock Mass in Subway Open-cut Station
Authors: Liu Quanwei , Tian Jiawei , Liu Yankai , Jiang Qichen , Wang Meng , Liu Linsheng , Liu Rentai 
Published: November 2020

Abstract
In the process of subway open-cut station construction, excavation deformation seriously threatens the safety of municipal pipelines and buildings. To ensure the effectiveness of grouting reinforcement, drilling exploration and pressure water test were conducted on the basis of the grouting reinforcement project of the excavation of an open-pit station in Qingdao metro, the permeability coefficient and crack characteristics were studied, and the equivalent crack width was calculated on the basis of cubic law. To determine the injectability index of grout and realize the optimal selection of grouting materials, the statistical distribution law of the equivalent crack width was analyzed on the basis of the Pareto distribution, and an effective method of grout selection was proposed. The PQT curve in the grouting process was analyzed by flow dimension theory to realize the dynamic adjustment of the grouting process. Finally, the grouting reinforcement effect was evaluated on the basis of the core sample and borehole TV. Results show that if the permeability coefficient is subject to Pareto distribution with parameters tmin and k, then the distribution curve of the permeability coefficient in the logarithmic coordinate is a straight line; the equivalent crack width obtained on the basis of the cubic law is also subject to the Pareto distribution with parameters bmin and 3k. Therefore, the equivalent crack width distribution curve can be obtained to provide a basis for the grout selection.
Study on the Method of Constructing Engineering Geological Three-dimensional Model of Hydrate Area in South China Sea Based on ArcGIS
Authors: Yang J P , Shi Y H , Chen M , He J , Chen K H , Hou J M 
Published: November 2020

Abstract
The trial production of marine natural gas hydrates (NGH) in China is gradually increasing, attracting concerns on related environmental issues. The entire regional conditions of engineering geological environment must be investigated thoroughly before NGH production. These conditions should be defined, among others, in terms of seabed topography, stratigraphic structure, soil types, physical and mechanical characteristics, hazardous geological factors and distributions, and hydrodynamic characteristics, which provide a variety of geological spatial information and can be obtained from different sources. Due to the high cost and low efficiency of deep-sea engineering geological drilling, only few stations can be deployed. Hence, not enough data are available for the construction three-dimensional (3D) geological models. This study considered the data of only a few drilling stations and compared them with well logging and 3D seismic data. First, the engineering geological standard strata were established. Second, we interpreted and exported the stratigraphic (based on virtual boreholes) and spatial information (in terms of X, Y, and Z) of existent geological structures in GeoFrame. Finally, using several technical modules of ArcGIS (i.e., ArcMap, ArcScene, ArcCatalog), we constructed a spatial database and a comprehensively intuitive 3D visualization data management platform for engineering geological environmental surveys and evaluations in the hydrate area. By clicking any element included in the platform, the correspondent data or results can be looked over: this efficient and continuous systematic database can be used to support the future production of NGH in the area.
DEM simulation of the complete triaxial test of sandstone
Authors: Li Lei , Huang Jun Guang , Li Wei Ke , Jiang Ming Jing 
Published: November 2020

Abstract
Complete triaxial tests considering residual strength are of great significance in analyses of the mechanical properties of rock in deep-rock engineering. In this paper, the complete triaxial test of Berea sandstone was quantitatively simulated using the discrete element method. The macro- and micromechanical properties of Berea sandstone were analyzed, and the following conclusions were obtained: (1) As the confining pressure increases, the peak and residual strengths of the sample increases, the stress–strain curves gradually change from softening to hardening, and the volume curves gradually change from dilatancy to shrinkage. (2) When the confining pressure is low, bond failure between particles mainly occurs under the state of tensile stress. As the confining pressure increases, compressive state failure gradually exceeds tensile state failure. (3) Under different confining pressures, the energy dissipated by friction between particles is far greater than other forms of energy dissipation and the energy dissipated by rolling between particles is always greater than the energy dissipated by twisting.