bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sitting/lying time is associated with waist‐to‐hip increase but not with body weight increase or blood cardiovascular risk factors changes in adult women living in social vulnerability: A 2‐year longitudinal study
Authors: Vieira Nathalia F. L. , Bueno Nassib B. , Silva Sirley M. , Lins Isabela L. , Albuquerque Fabiana C. , Macêna Mateus L. , Silva‐Júnior André E. , Pureza Isabele M. , Clemente Ana G. , Florêncio Telma T. 
Published: December 2019

AbstractObjectiveThe present study aimed to determine whether physical activity and energy intake are associated with the anthropometric and blood cardiovascular risk factors alterations in women living in social vulnerability for a period of 2 years.MethodsThe study was carried out with women residing in the outskirts of Maceió‐AL, aged between 19 and 45 years. We characterized the socioeconomic and biochemical profile (glucose, insulin, and blood lipids) at the beginning and at the end of the study. Anthropometric evaluation was performed in three moments: at the beginning, and after 1 and 2 years of follow‐up. Energy expenditure, measured by doubly labeled water, physical activity, measured by 7‐day triaxial accelerometry, and energy intake, measured by 3‐day 24‐hour food recall, were collected at baseline.ResultsAfter 2 years, 34 women were completely assessed, with a mean age of 33.7 years. Women spent around 16 hours of the day sitting/lying down. There was an increase in body weight (from 64.61 ± 11.69 to 66.37 ± 13.26 kg, P < .01), which was not associated with any of the predictors. There was also an increase in waist/hip ratio (WHR) (from 0.84 ± 0.07 to 0.87 ± 0.05, P < .01), which was positively associated with the amount of sitting/lying time per day. There were no significant alterations in blood cardiovascular risk factors.ConclusionEnergy intake did not predict anthropometrical changes. Sitting/lying time was associated with an increase in WHR, but not in body weight or blood cardiovascular risk factors in low‐income women.
In vivo formation of spherical and rod lead nanoparticles in root cells of water velvet (Azolla pinnata)
Authors: Chumpol Jiraporn , Siri Sineenat 
Published: December 2019

AbstractSeveral plant species survive in the metal‐contaminated environment by minimization of detrimental effects of metal exposure and cellular accumulation, but little is known about their capability to transform the uptake metal ions into nanoparticles, especially in nonspherical shapes. This work firstly reported the in vivo formation of spherical and rod‐shaped lead nanoparticles (PbNPs) from the uptake lead ions in root cells of water velvet (Azolla pinnata). The energy‐dispersive X‐ray fluorescence analysis revealed the high level of lead (67.21 ± 0.70%) and the modulated levels of sulfur, potassium, and calcium in the treated roots. Fourier‐transform infrared spectroscopy spectral analysis suggested the changes of biochemical constituents in Pb‐treated roots, including carbohydrates, organic compounds, proteins, and nucleic acids. Transmission electron microscope (TEM) images revealed the formation of spherical, short rod, and long rod PbNPs dominantly in epidermal, cortical, and vascular cells in the plant roots, respectively. The analyses of energy‐dispersive X‐ray spectroscopy, high‐resolution TEM, and selected area diffraction TEM indicated the body‐centered tetragonal lattice of lead oxide nanoparticles (PbONPs) in the root cells.
3D Printing of Electrochemical Energy Storage Devices: A Review of Printing Techniques and Electrode/Electrolyte Architectures
Authors: Cheng Meng , Deivanayagam Ramasubramonian , Shahbazian‐Yassar Reza 
Published: December 2019

AbstractRecently, the fabrication of electrochemical energy storage (EES) devices via three‐dimensional (3D) printing has drawn considerable interest due to the enhanced electrochemical performances that arise from well‐designed EES device architectures as compared to the conventionally fabricated ones. This work summarizes the developments in electrochemical devices fabricated by 3D printing techniques. We have categorized this review based on the architectural design of 3D printed EES devices: interdigitated structures, 3D scaffolds, and fibers. The printing techniques, processes, printing materials, advantages, and disadvantages of 3D printed architectures are systematically discussed in this review. Enhanced power density and energy density values were obtained using interdigitated structures and 3D scaffolds, in comparison with the conventional planar structure. The reasons for better electrochemical performances can be attributed to the presence of higher loading active materials, larger footprint area, and shorter ion transport route. The 3D printing techniques have also enabled the EES devices to be fabricated into lightweight, flexible fibers, and to be integrated into wearable electronics. At the end, the challenges and outlooks on the fabrication of 3D structured EES devices are outlined.
Application of a kNN‐based similarity method to biopharmaceutical manufacturing
Authors: Ren Jun , Zhou Roland , Farrow Michael , Peiris Ramila , Alosi Tim , Guenard Rob , Romero‐Torres Saly 
Published: December 2019

AbstractMachine learning‐based similarity analysis is commonly found in many artificial intelligence applications like the one utilized in e‐commerce and digital marketing. In this study, a kNN‐based (k‐nearest neighbors) similarity method is proposed for rapid biopharmaceutical process diagnosis and process performance monitoring. Our proposed application measures the spatial distance between batches, identifies the most similar historical batches, and ranks them in order of similarity. The proposed method considers the similarity in both multivariate and univariate feature spaces and measures batch deviations to a benchmarking batch. The feasibility and effectiveness of the proposed method are tested on a drug manufacturing process at Biogen.
Preemptive Anti–Stress Response Effects of Oxycodone Versus Sufentanil for Patients Undergoing Cardiac Valve Replacement—A Randomized Controlled Trial
Authors: Zhang Jian , Tu Qing , Gan Jianhui , Miao Shuai , Zhou Ying , Li Qiang , Zheng Chuandong 
Published: December 2019

AbstractPatients undergoing cardiac valve replacement may experience cardiovascular adverse events during the preoperative period before anesthesia. The study was to compare the preemptive anti–stress response effects of oxycodone versus sufentanil for patients undergoing cardiac valve replacement. Ninety‐four patients were enrolled and assigned to group Oxy, group Suf and group NS. Patients in group Oxy were administrated with oxycodone 0.1 mg/kg, group Suf received sufentanil 0.1 μg/kg and group NS were given equivalent volume of normal saline. The primary outcomes included serum levels of cortisol, norepinephrine, and adrenaline. The secondary outcomes involved bispectral index value and the observer's assessment of awareness/sedation grade, levels of mean arterial pressure, heart rate, and the adverse reactions. Compared to group NS, the serum levels of cortisol at T1 to T5 (P < .05), and levels of norepinephrine and adrenaline at T3 to T5 (P < .05) in group Oxy and Suf were lower. The bispectral index value and observer's assessment of awareness/sedation grade T1 to T2 (P < .05) in group Suf were lower than those in group Oxy and NS. Compared with group NS, the levels of mean arterial pressure and heart rate in group Oxy and Suf at T3 to T5 (P < .05) were lower. The incidence of coughing was significantly higher in group Suf (23.3%), but not in group NS (6.7%), than that in group Oxy (3.3%). The preemptive analgesia of oxycodone may be used to inhibit the stress response, without leading to excessive sedation and respiratory depression, which may also help to stabilize hemodynamics during preoperative period.
Unveiling RNA‐Binding Properties of Verapamil and Preparation of New Derivatives as Inhibitors of HIV‐1 Tat‐TAR Interaction
Authors: Martin Céline , De Piccoli Serena , Gaysinski Marc , Becquart Cécile , Azoulay Stéphane , Di Giorgio Audrey , Duca Maria 
Published: December 2019

AbstractTargeting RNA using small molecules is now established as a very promising strategy for many therapeutic applications since coding and non‐coding RNAs bear a pivotal role both in viral and bacterial infections as well as in diseases such as cancer. Here, we focused on HIV‐1 TAR RNA as a promising target for the development of new anti‐HIV therapies but also as an ideal model to validate the discovery of original RNA ligands. First, we performed an initial screening of a library of compounds against TAR that led to the discovery of verapamil, a marketed calcium‐channel blocker, as a promising chemical structure for the development of new RNA ligands. The synthesis of a series of analogs of verapamil led to promising structure activity relationships and to the discovery of a conjugate between verapamil and an indole fragment, as an efficient and selective TAR binder able to inhibit Tat/TAR interaction with an IC50 of 18.8 μM. This work supports the potential of library screening for the discovery of original and selective RNA ligands and illustrates how existing drugs directed against protein targets still need to be studied for RNA binding as a promising strategy in the field of RNA targeting by small molecules.
An area‐efficient, large time‐constant log‐domain filter for low‐frequency applications
Authors: G. Hanumantha Rao , S. Rekha 
Published: December 2019

SummaryThis paper proposes a simple technique to increase the time constant of a log‐domain filter. By using the proposed technique, the capacitor value can be reduced considerably; hence, overall area of the circuit can be reduced. A second‐order log‐domain low‐pass filter (LPF) is implemented in UMC 65‐nm complementary metal‐oxide semiconductor (CMOS) technology to validate the proposed technique. It occupies an area as low as 0.005 mm2 and operates with a 0.5‐V supply. For a cutoff frequency of 100 Hz, the filter consumes a power of 4 nW. By adjusting the bias current, the cutoff frequency can be linearly tuned from 10 to 500 Hz. The filter has the figure of merit (FoM) of 0.68×10−13 J, which is on par with many designs listed in the literature. The filter uses the lowest capacitance/pole (0.92 pF) among the similar designs given in the literature, which shows that the present design is area efficient.
Front Cover: Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity (J. Biophotonics 12/2019)
Authors: Salajkova Sarka , Sramek Michal , Malinak David , Havel Filip , Musilek Kamil , Benkova Marketa , Soukup Ondrej , Vasicova Pavla , Prchal Lukas , Dolezal Rafael , Hodny Zdenek , Bartek Jiri , Zarska Monika , Kuca Kamil 
Published: December 2019

Cationic gold nanorods stabilized by quaternary ammonium salts (QAS) are a promising tool for photothermal destruction of cancer cells. However, cytotoxicity of the alkanethiol‐QAS limits their medical applications. A novel design of cationic surfactant composed of the quaternary ammonium group and ethylene glycol chain significantly reduces the compound cytotoxicity in the free state while allowing the preparation of stable nanorods with high cellular uptake and lysosomal localization.Further details can be found in the article by Sarka Salajkova, Michal Sramek, David Malinak, et al. (e201900024).
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Inside Cover: Three‐dimensional intravital imaging in bone research (J. Biophotonics 12/2019)
Authors: Liu Yuhao , Yuan Quan , Zhang Shiwen 
Published: December 2019

This review is aimed at interpreting development and advantages of intravital imaging as an emerging invaluable methodology and summarizing related representative discoveries in bone physiologies and pathologies. It also indicates current limitations, further refinement, and extended application of intravital imaging in bone research.Further details can be found in the article by Yuhao Liu, Quan Yuan, and Shiwen Zhanget (e201960075).
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Dissolution of collagen fibers from tannery solid wastes in salt aqueous solutions: Hofmeister series evaluation
Authors: Zhang Luan , Li Zhijie , Xiao Yuelong , Liu Zhijing , Pei Ying , Wang Guozhen , Tang Keyong 
Published: December 2019

AbstractBACKGROUNDCollagen fibers from tannery solid wastes were treated with aqueous solutions of inorganic salts. The effect of the inorganic salts on the dissolution of collagen fibers and degradation of collagen were investigated. Tests of reduced viscosity and sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS‐PAGE) were applied to evaluate the degree of degradation during the dissolution process. The specific ionic effects of the Hofmeister series on the dissolution of collagen fibers in salt aqueous solutions were demonstrated.RESULTSAccording to all the results, the dissolution abilities of inorganic salts were in the order of Br− > Cl− > SCN− > CH3COO− > H2PO4− > CO32− as well as Na+ > Mg2+ > Ca2+ > NH4+ > K+ > Li+. The results indicated that NaBr aqueous solution could have potential ability as a solvent to dissolve collagen fibers without excessive degradation of collagen.CONCLUSIONSNaBr aqueous solution could have potential ability as a solvent to dissolve collagen fibers without excessive degradation of collagen. By analyzing the results of the reduced viscosity tests, SDS‐PAGE and amino analysis, proper dissolution conditions were evaluated with the conditions of NaBr aqueous solution concentration of 1 mol L−1, contacting time of 4 h and temperature of 60 °C. From amino analysis and in situ optical microscopy observation, a possible process of collagen fiber dissolution in NaBr solution was demonstrated. This work provides a method for treating and recycling tannery solid wastes with some information for the investigation of collagen‐based materials. © 2019 Society of Chemical Industry
Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study
Authors: Hosoi Takahiro , Ozone Sachiko , Hamano Jun 
Published: December 2019

AbstractBackgroundThe prediction of short‐term survival is important for noncancer patients and their families. Although a markedly reduced oral intake by cancer patients suggests a poor prognosis, the survival times of noncancer patients after its onset remain unclear. We herein investigated the time from a marked reduction in oral intake to death in noncancer patients as well as factors associated with their subsequent survival.MethodsWe conducted a retrospective medical record review of noncancer patients who died in our hospital between April 2017 and April 2018. We recorded the day when oral intake markedly decreased and the date of death. We extracted data on age, gender, the Charlson Comorbidities Index, mean daily fluid volume, laboratory test results, and vital signs converted to the Shock Index (SI). We used Cox's proportional hazards models to assess relationships between these factors and survival times after the onset of a markedly reduced oral intake.ResultsWe analyzed data from 44 noncancer patients. The median time from the onset of a markedly reduced oral intake to death was 16.5 days. Based on Cox's proportional hazards models, only SI ≧ 1.0 at the onset of a markedly reduced oral intake correlated with survival times (hazard ratio: 5.89, 95% confidence interval (CI): 1.71‐20.1, P = .005).ConclusionNoncancer patients died a median of 16.5 days after the onset of a markedly reduced oral intake, and SI ≧1.0 correlated with subsequent survival times. These results will provide novel insights into the prognosis of noncancer patients at the end of life.
Synthesis, reactions, and spectral characterization of some new biologically active compounds derived from thieno[2,3‐c]pyrazole‐5‐carboxamide
Authors: Saber Ahmed F. , Zaki Remon M. , Kamal El‐Dean Adel M. , Radwan Shaban M. 
Published: December 2019

AbstractThe starting compound 4‐amino‐3‐methyl‐1‐phenyl‐1H‐thieno[2,3‐c]pyrazole‐5‐carboxamide (1), that has been previously synthesized according to the literature procedure, underwent a reaction with the anhydride of phthalic acid either in AcOH or DMF to give isoindolinylpyrazole‐5‐carboxamide 3 and pyrazolothienopyrimidoisoindoledione 4, respectively. Also, it was subjected to react with diethylmalonate followed by hydrazinolysis by hydrazine hydrate to yield the pyrazolothienopyrimidinyl acetohydrazide 5. The carbohydrazide derivative 5 was used as a key intermediate for the preparation of other new heterocyclic systems containing pyrazolylacetyl pyrazolothienopyrimidines and pyrazolothieno‐pyrimidotriazepine compounds 6–11. The structures of these new heterocycles have been characterized by using analytical and spectroscopic analyses (IR, 1H‐NMR, 13C‐NMR and MS). Some derivatives of the synthesized compounds exhibited remarkable antibacterial and antifungal activities against many bacterial and fungal strains.
A simple route to morpholine derivatives via copper‐acetylide addition to carbodiimide in the presence of oxiranes
Authors: Samzadeh‐Kermani Alireza 
Published: December 2019

AbstractA novel catalytic multicomponent reaction for the synthesis of morpholine derivatives has been reported. The reactions involve terminal alkynes, carbodiimides, and oxiranes using [Cu (CH3CN)4]PF6, tBuOLi, and TBPAc in anhydrous NMP. Aryl and heteroaromatic terminal alkynes were tolerated. Carbodiimides could be symmetrical and unsymmetrical substrates with aryl or alkyl substituents. The reaction exhibited a good regioselectivity when unsymmetrical carbodiimides were employed.
Highlights on the synthesis of novel phenothiazine‐based azines scaffold as antioxidant agents
Authors: Hamama Wafaa S. , Gouda Moustafa A. , Kamal El‐din Hadwah A. , Zoorob Hanafi H. 
Published: December 2019

AbstractAzines derivatives of phenothiazines were synthetically constructed from one‐pot multicomponent reactions of 1‐(4a,10a‐dihydro‐10H‐phenothiazin‐2‐yl)ethan‐1‐one with various reagents. The obtained novel target compounds were evaluated as antioxidant agents using ABTS+• scavenging assay. Antioxidant results revealed that the incorporation of azines to phenothiazine ring system enhanced the activity. In addition, compound 18 prevent the damage of DNA due to the formation of bleomycin‐iron complex more than the standard compound.
Effect of postoperative steroids on clinical outcomes and radiographic findings of horizontal alveolar ridge augmentation: A retrospective study
Authors: Golob Deeb Janina , Farris Emily , Reichert Amy , Carrico Caroline K. , Deeb George R. 
Published: December 2019

AbstractBackgroundThe purpose of the study was to investigate if the prescription of oral postoperative steroids has an effect on clinical outcomes of horizontal ridge augmentation including implant placement and characteristics of the grafted bone.MethodsA retrospective chart review of 73 horizontal ridge augmentation cases was completed to assess the clinical outcomes, 53 of those cases were further assessed radiographically. Information was gathered regarding surgical technique, grafting materials, postoperative healing, medications used postoperatively, bone growth, and density changes as quantified on a cone‐beam computed tomography (CBCT) scan. Statistical analysis was completed to identify whether the use of postoperative oral steroids altered outcomes.ResultsSteroids were used postoperatively following various horizontal ridge augmentation procedures. The use of tenting screws and resorbable membranes with a combination of osseous allograft and xenograft was used in 73 cases, 53 of which had preoperative and postoperative CBCT scans. Graft exposure occurred in five of the cases (9%), with the majority (n = 4) among those with postoperative steroids, but this was not statistically significant (P‐value = 0.6510). Use of steroids was also not significantly associated with the number of courses of antibiotics (P‐value > 0.05), but it was significantly associated with increased number of postoperative visits (P‐value < 0.05). Among the subset for radiographic analysis (n = 53), there were significant clinical and radiographic dimensional changes in alveolar ridge width with an average horizontal bone gain of 3.6 mm. There were no statistically significant differences found in radiographic linear bone gain or clinical outcomes with the addition of steroids. A marginally statistically significant in the density of grafted bone was found with the addition of steroids (P‐value > 0.05).ConclusionThe prescription of postoperative steroids did not make a significant difference in clinical outcomes, success of implant placement or on radiographic assessment of grafted sites following horizontal alveolar ridge augmentation.
Surgical treatment of otosclerosis leading to changes in postural control and quality of life
Authors: Alessandrini Marco , Viziano Andrea , Roselli Lucrezia , Micarelli Alessandro 
Published: December 2019

ObjectiveEvaluating postural function in patients with otosclerosis by assessing otoneurological function and balance‐related quality of life before and 6 weeks after surgical treatment. Correlations between and clinical features were investigated.MethodsThirty‐three patients affected by otosclerosis underwent otoneurological examination, video Head Impulse Test (vHIT), and static posturography before and after stapedotomy. Quality of life and dizziness‐related handicap were screened by means of validated questionnaires. Correlation analysis was performed in order to discover possible relations with audiological pre‐ and postoperative parameters.ResultsA significant improvement in posturographic parameters was found. Correlation analysis yielded a negative correlation between preoperative bone conduction auditory threshold and both vHIT scores and postural performance improvement, evaluated by spectral analysis. Moreover, a positive correlation was also found between improvements in posturographic scores and quality‐of‐life questionnaires.ConclusionThe study results demonstrated an improvement in postural function and self‐reported measures in a cohort of patients with otosclerosis 6 weeks after stapedotomy. The inverse correlation with preoperative auditory levels may reflect lesser chance for balance restoration in cases with worse sensorineural function. Possible implications for daily activities and overall quality of life were suggested by improved self‐report questionnaire results.Level of Evidence4 Laryngoscope, 130:2448–2454, 2020