bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abivertinib in patients with T790M‐positive advanced NSCLC and its subsequent treatment with osimertinib
Authors: Wang Hanping , Pan Ruili , Zhang Xiaotong , Si Xiaoyan , Wang Mengzhao , Zhang Li 
Published: January 2020

AbstractBackgroundAbivertinib is a novel oral, third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that overcomes T790M‐induced resistance in non‐small cell lung cancer (NSCLC) patients. Here, we report the results of a complete and detailed clinical data of patients treated with abivertinib at our hospital in a phase I dose escalation/expansion study of abivertinib.MethodsNSCLC patients with the EGFR T790M mutation were orally administered abivertinib (150–300 mg) twice daily for cycles of 28 continuous days and tumor response was assessed. Further data regarding subsequent treatment protocols and survival were collected.ResultsA total of 28 NSCLC patients were included. Of the 24 assessable patients, 12 (50%) achieved a partial response (PR), and six (25%) achieved stable disease (SD). Median progression‐free survival (PFS) was 5.9 months (95% confidence interval (CI): 3.259–8.541) and median overall survival (OS) was 17.9 months (95% CI: 11.36–24.5). For salvage therapy in 15 (53.6%) patients after abivertinib, the median PFS following osimertinib treatment was 12 months. The median total treatment duration for the two third‐generation EGFR TKIs was 15.9 months (95% CI: 12.5–19.3). The most frequent abivertinib‐associated adverse effects were elevated hepatic transaminases (10/28, 35.7%) and diarrhea (10/28, 35.7%).ConclusionsAbivertinib is a unique novel third‐generation EGFR TKI with good tolerance and efficacy in EGFR T790M(+) NSCLC patients. For patients with progressive disease after treatment with abivertinib, osimertinib could be an option for subsequent therapy but further studies are required.Key points
Abivertinib is a novel third‐generation EGFR TKI targeting the EGFR T790M mutation
Abivertinib is well tolerated and efficacious in T790M‐positive patients
Abivertinib has a unique structure, efficacy, and resistance mechanism compared with osimertinib
Osimertinib treatment after AC0010 showed a good response
The PalaeoEnvironments and ARchaeological Landscapes (PEARL) project: Recent findings from Neolithic sites in Northern Oman
Authors: Parton Ash , Bretzke Knut 
Published: January 2020

The PalaeoEnvironments and ARchaeological Landscapes (PEARL) research project is a joint German–British project with the principal objective of developing a framework of past human occupation and landscape change in south‐eastern Arabia. Fieldwork during 2018 and 2019 involved the systematic survey and excavation of sites in the Rustaq and Ibri regions of Northern Oman, with the aim of establishing the nature and timing of human occupation and landscape change during the Early Holocene period (c. 10,000–7,000 years BP). Further to the findings previously reported, results from recent excavations of the site Hayy al‐Sarh in Rustaq revealed the presence of animal remains, stone and shell beads and stone structures, indicating a large Neolithic settlement with burial areas. In addition, preliminary excavations at a rock shelter site near Ibri have revealed stratified archaeological remains, including a Fasad‐type assemblage. Future fieldwork will further develop archaeological and palaeoenvironmental records to help build a framework for studying cultural and natural developments in Northern Oman.
Development of a computerized adaptive substance use disorder scale for screening and measurement: the CAT‐SUD
Authors: Gibbons Robert D. , Alegria Margarita , Markle Sheri , Fuentes Larimar , Zhang Liting , Carmona Rodrigo , Collazos Francisco , Wang Ye , Baca‐García Enrique 
Published: January 2020

AbstractBackground and aimsThe focus of this paper is on the improvement of substance use disorder (SUD) screening and measurement. Using a multi‐dimensional item response theory model, the bifactor model, we provide a psychometric harmonization between SUD, depression, anxiety, trauma, social isolation, functional impairment and risk‐taking behavior symptom domains, providing a more balanced view of SUD. The aims are to (1) develop the item‐bank, (2) calibrate the item‐bank using a bifactor model that includes a primary dimension and symptom‐specific subdomains, (3) administer using computerized adaptive testing (CAT) and (4) validate the CAT‐SUD in Spanish and English in the United States and Spain.DesignItem bank construction, item calibration phase, CAT‐SUD validation phase.SettingPrimary care, community clinics, emergency departments and patient‐to‐patient referrals in Spain (Barcelona and Madrid) and the United States (Boston and Los Angeles).Participants/casesCalibration phase: the CAT‐SUD was developed via simulation from complete item responses in 513 participants. Validation phase: 297 participants received the Composite International Diagnostic Interview (CIDI) and the CAT‐SUD.MeasurementsA total of 252 items from five subdomains: (1) SUD, (2) psychological disorders, (3) risky behavior, (4) functional impairment and (5) social support. CAT‐SUD scale scores and CIDI SUD diagnosis.FindingsCalibration: the bifactor model provided excellent fit to the multi‐dimensional item bank; 168 items had high loadings (> 0.4 with the majority > 0.6) on the primary SUD dimension. Using an average of 11 items (four to 26), which represents a 94% reduction in respondent burden (average administration time of approximately 2 minutes), we found a correlation of 0.91 with the 168‐item scale (precision of 5 points on a 100‐point scale). Validation: strong agreement was found between the primary CAT‐SUD dimension estimate and the results of a structured clinical interview. There was a 20‐fold increase in the likelihood of a CIDI SUD diagnosis across the range of the CAT‐SUD (AUC = 0.85).ConclusionsWe have developed a new approach for the screening and measurement of SUD and related severity based on multi‐dimensional item response theory. The bifactor model harmonized information from mental health, trauma, social support and traditional SUD items to provide a more complete characterization of SUD. The CAT‐SUD is highly predictive of a current SUD diagnosis based on a structured clinical interview, and may be predictive of the development of SUD in the future.
Impact of opioid dose escalation on the development of substance use disorders, accidents, self‐inflicted injuries, opioid overdoses and alcohol and non‐opioid drug‐related overdoses: a retrospective cohort study
Authors: Hayes Corey J. , Krebs Erin E. , Hudson Teresa , Brown Joshua , Li Chenghui , Martin Bradley C. 
Published: January 2020

AbstractAimTo understand the potential harmful effects of dose escalation among patients with chronic, non‐cancer pain (CNCP) on chronic opioid therapy.DesignRetrospective cohort study.SettingUnited States Veterans Healthcare Administration.ParticipantsVeterans with CNCP and on chronic opioid therapy were identified using data from fiscal years 2008–15. The Veteran sample was approximately 90% male and 70% white.MeasurementsDose escalators [increase of > 20% average morphine milligram equivalent (MME) daily dose] were compared with dose maintainers (change of ±20% average MME daily dose). A composite measure of subsequent substance use disorders (SUDs: opioid, non‐opioid and alcohol use disorders) and opioid‐related adverse outcomes (AOs: accidents resulting in wounds/injuries, opioid‐related and alcohol and non‐opioid medication‐related accidents and overdoses, self‐inflicted injuries) as well as the individual SUDs and AOs was examined. The primary analyses were conducted among a 1 : 1 matched sample of escalators and maintainers matched on propensity score and index date. Propensity scores were generated using demographic characteristics, medical comorbidities, medication and health‐care utilization characteristics. Subgroup analyses were conducted by quartile of the propensity score. Sensitivity analyses were conducted using adjusted logistic regression, logistic regression using stabilized inverse probability of treatment weighting (SIPTW) and instrumental variable (IV) models using geographic variation in opioid dose escalation as the IV.FindingsThere were 32 420 maintainers and 20 767 escalators resulting in 19 358 (93.2%) matched pairs. Composite AOs [odds ratio (OR) = 1.31, 95% confidence interval (CI) = 1.23, 1.40], composite SUDs (OR = 1.31, 95% CI = 1.22, 1.41) and individual SUD and AO subtypes were higher among dose escalators, except for opioid‐related accidents and overdoses and violence‐related injuries. Subgroup analyses within the propensity score quartiles found similar results. Sensitivity analyses with the adjusted and SIPTW logistic regressions found similar results to the primary analyses for all outcomes except for opioid‐related accidents and overdoses, which were found to be significantly higher among escalators. Sensitivity analyses with IV models provided mixed results with SUDs and the individual types of AOs.ConclusionEscalating the opioid dose for those with chronic, non‐cancer pain is associated with increased risks of substance use disorder and opioid‐related adverse outcomes.
Dieulafoy lesion in a Hartmann stump
Authors: Gundogan Ersin , Karabulut Ertugrul , Ersan Veysel , Kayaalp Cuneyt 
Published: January 2020

AbstractA 70‐year‐old man underwent laparoscopic anterior resection for sigmoid carcinoma, and on postoperative day 4, he required an emergency Hartmann procedure for bowel ischemia and anastomotic leakage. Five days after the emergency procedure, there was a massive hemorrhage through the anus that appeared in the abdominal drain. During exploration, the origin of the bleeding could not be found, and the rectal stump was closed over a urinary Foley catheter (with an inflated balloon) with the help of a purse‐string suture. In the intensive care unit, massive hematochezia continued. Emergency transanal colonoscopy to the Hartmann stump found the rectum full of clotted blood. Active pulsatile arterial bleeding of a rectal Dieulafoy lesion was detected. After endoscopic hemostasis efforts failed, bleeding was stopped successfully by transanal suturing. The patient was discharged without any other problems, and no recurrent bleeding occurred during the 18‐month follow‐up. Here, we report a rectal Dieulafoy lesion in a Hartmann stump for the first time.
Key considerations and challenges in the application of social‐network research for environmental decision making
Authors: Guerrero A. M. , Barnes M. , Bodin Ö. , Chadès I. , Davis K. J. , Iftekhar M. S. , Morgans C. , Wilson K. A. 
Published: January 2020

AbstractAttempts to better understand the social context in which conservation and environmental decisions are made has led to increased interest in human social networks. To improve the use of social‐network analysis in conservation, we reviewed recent studies in the literature in which such methods were applied. In our review, we looked for problems in research design and analysis that limit the utility of network analysis. Nineteen of 55 articles published from January 2016 to June 2019 exhibited at least 1 of the following problems: application of analytical methods inadequate or sensitive to incomplete network data; application of statistical approaches that ignore dependency in the network; or lack of connection between the theoretical base, research question, and choice of analytical techniques. By drawing attention to these specific areas of concern and highlighting research frontiers and challenges, including causality, network dynamics, and new approaches, we responded to calls for increasing the rigorous application of social science in conservation.
Analytics for Cross‐Border E‐Commerce: Inventory Risk Management of an Online Fashion Retailer
Authors: Shi Ye , Wang Ting , Alwan Layth C. 
Published: January 2020

ABSTRACTProblem statement: We present a data‐driven analytics study of a Chinese fashion retailer. The retailer fulfills cross‐border orders using online platforms, but faces inventory problems in its overseas warehouses, owing to operational complexities, such as extensive product offerings, high demand risks, and tax risks in cross‐border trade. Traditional approaches (e.g., model‐driven approaches) often fail to provide effective solutions. Therefore, this study proposes a new data‐driven approach to manage inventory in overseas warehouses.Methodology: A two‐stage predictive analytics approach is implemented, as follows: (i) all items are classified into one of two classes, where ‐items are profitable to store in overseas warehouses, but ‐items are not; (ii) the demand levels of SKUs of ‐items are predicted. In the subsequent prescriptive analytics, models are proposed for optimizing inventory decisions related to ‐items. These include a deterministic model that uses the predicted demand as the true demand, and a stochastic model that treats the true demand as a random variable.Results: (i) Using a variety of machine learning techniques in the predictive analytics phase, we find the random forest outperforms other methods. (ii) The deterministic model can be solved as a linear program, and the stochastic model with maximum entropy distributions can be solved using Karush–Kuhn–Tucker conditions. (iii) An application of our results shows that the predictive classification reduces costs (an average cost reduction of up to 20%) by avoid shipping unprofitable items to overseas warehouses. Furthermore, the stochastic model provides near‐optimal solutions (the smallest performance loss is just 0.00%).
Selection for psychosocial treatment for youth at clinical high risk for psychosis based on the North American Prodrome Longitudinal Study individualized risk calculator
Authors: Worthington Michelle A. , Miklowitz David J. , O'Brien Mary , Addington Jean , Bearden Carrie E. , Cadenhead Kristin S. , Cornblatt Barbara A. , Mathalon Daniel H. , McGlashan Thomas H. , Perkins Diana O. , Seidman Larry J. , Tsuang Ming T. , Walker Elaine F. , Woods Scott W. , Cannon Tyrone D. 
Published: January 2020

AbstractAimRecent findings suggest that family‐focused therapy (FFT) is effective for individuals at clinical high‐risk for psychosis (CHR‐P). As outcomes of CHR‐P individuals are quite varied, certain psychosocial interventions may be differentially effective in subgroups. The present study examined change in positive symptoms for CHR‐P individuals at different levels of predicted risk for conversion to psychosis who received either FFT, a brief form of family education termed enhanced care (EC) or treatment as usual.MethodsParticipants were drawn from the North American Prodromal Longitudinal Study (NAPLS2). A subset of NAPLS2 participants completed a randomized study involving FFT or EC. The present study includes participants from the FFT‐CHR sub‐study and non‐randomized NAPLS2 participants. Predicted risk of conversion was calculated using the Individualized Risk Calculator for Psychosis. Robust linear regressions evaluated whether the association between predicted risk of conversion and positive symptom change differed across intervention groups.ResultsA total of 94 participants from the FFT‐CHR sub‐study (FFT‐CHR n = 50, EC n = 44) and 401 non‐randomized NAPLS2 participants were included in this study. There was a treatment group by predicted risk of conversion interaction that predicted positive symptom improvement: higher risk individuals improved more with FFT‐CHR than EC or the non‐randomized NAPLS group, whereas lower‐risk individuals did not differ in positive symptom improvement across treatment groups (FFT‐CHR vs EC: P = .03, β = 20.27; FFT‐CHR vs NAPLS2: P < .001, β = 28.40).ConclusionsIntensive treatments such as FFT‐CHR may be most appropriate for individuals at the highest levels of clinical risk for psychosis.
Translation and preliminary validation of an ageism scale for dental students in Brazil (ASDS‐Braz)
Authors: Rucker Ryan , Barlow Patrick B. , Bertolini Fernandes dos Santos Mateus , Carrera Malhao Eduarda , Kossioni Anastassia , Marchini Leonardo 
Published: January 2020

AbstractBackground and ObjectiveAgeism is a major barrier for age‐appropriate care. The aim of this study was to translate and perform a preliminary validation of an ageism scale for dental students (ASDS) in Brazil (ASDS‐Braz).MethodsThe 27‐item original ageism scale was translated from English into Brazilian Portuguese. A panel of five Brazilian dental educators revised the scale to establish content validity. The translated version was completed by 156 dental students in the Federal University of Pelotas in Brazil. Principal component analysis, internal consistency reliability and discriminant validity were estimated.ResultsAll items in the Brazilian Portuguese version received a content validity index score ≥0.80 indicating that they were relevant to the topic. The principal component analysis produced a 12‐item scale with three components that accounted for 51% of the overall variance. The first component contained six items associated with a negative view of older adults; the second component contained three items dealing with the complexity of providing care for older adults; and the third component contained three items associated with a positive view of older people. Discriminant validity did not show any differences related to demographic factors, the semester of studies and history of living with older people.ConclusionsThe preliminary validation of the ASDS‐Braz produced a 12‐item scale with three components with acceptable validity and reliability. Future research in a larger, multi‐institutional sample is now warranted.
Temporary vocal cord paralysis following hemodialysis catheter placement
Authors: Murt Ahmet , Dincer Mevlut T. , Karaca Cebrail , Trabulus Sinan , Altiparmak Mehmet R. , Seyahi Nurhan 
Published: January 2020

AbstractWe report a case of temporary right vocal cord paralysis manifesting as hoarseness after hemodialysis, beginning several hours after placement of a non‐cuffed hemodialysis catheter into the right internal jugular vein using prilocaine local anesthesia. Diagnosis of right vocal cord paralysis was confirmed by laryngoscopy. Hoarseness completely resolved that same day, and subsequent laryngoscopy showed normal vocal cord movement, suggesting that the most likely cause of the initial vocal cord paralysis was diffusion of the local anesthetic agent injected during catheter insertion.
Flexible and Assembled Bordering Practices for Mexicans travelling to Canada
Authors: Villegas Paloma E. 
Published: January 2020

AbstractThis article examines a temporary residence visa (TRV) requirement for Mexicans travelling to Canada 2009–2016. The policy was implemented to control the travel of Mexican refugee claimants to Canada, with the explanation that they were making “bogus” claims. Drawing on a critical discourse analysis of news sources, parliamentary debates, and policy documents, I argue that the TRV and subsequent policies and practices enacted during the 2009–2016 period illustrate bordering practices as flexible and assembled, regulating entry and access to secure immigration status. I analyse how bordering practices operated through the enactment of policy, the circulation of anti‐immigrant/anti‐Mexican discourses, and economic arguments about the cost of lifting the TRV. They were also affected by U.S.‐Canada relationships, particularly after the 2016 U.S. election.
Current approach to eating disorders: a clinical update
Authors: Hay Phillipa 
Published: January 2020

AbstractThis article presents current diagnostic conceptualisations of eating disorders, including new disorders such as binge eating disorder (BED) and avoidant/restrictive food intake disorder (ARFID). This is followed by contemporary findings in the epidemiology of eating disorders, their broad sociodemographic distribution and the increases in community prevalence. Advances and the current status of evidence‐based treatment and outcomes for the main eating disorders, anorexia nervosa, bulimia nervosa and BED are discussed with focus on first‐line psychological therapies. Deficits in knowledge and directions for further research are highlighted, particularly with regard to treatments for BED and ARFID, how to improve treatment engagement and the management of osteopenia.
Higher rates of carbapenem‐related seizures in older hospitalised adults
Authors: Neo Han‐Yee , Tan Keng‐Teng , Caroline Caroline , Wei‐Han Ng David , Pei‐Ying Ho Esther , Lim Jun‐Pei , Hsien‐Xiong Lee Raphael , Choon‐Kiat Tan Nigel , Chien‐Boon Lye David , Ding Yew‐Yoong 
Published: January 2020

AbstractClinical experience suggests higher occurrence of carbapenem‐associated seizures in the elderly than what is reported in the available literature (range between 0.2% and 0.7%). An audit of 1345 patients with age 60 years or older, who received imipenem, ertapenem or meropenem during their acute hospitalisation found 32 (2.4%) subjects developed seizures. Subjects with more than one central nervous system disorders were 11.6 times more likely to develop seizures (odds ratio 11.61, P < 0.001) and subjects with prior history of seizures is associated with four times greater risks (odds ratio 4.02, P = 0.005). Physicians should exercise caution when prescribing carbapenems in elderly, especially those with known epilepsy and a high number of intracranial pathologies.
Preparation of placental tissue transplants and their application in skin wound healing and chosen skin bullous diseases ‐ Stevens‐Johnson syndrome and toxic epidermal necrolysis treatment
Authors: Klama‐Baryła Agnieszka , Rojczyk Ewa , Kitala Diana , Łabuś Wojciech , Smętek Wojciech , Wilemska‐Kucharzewska Katarzyna , Kucharzewski Marek 
Published: January 2020

AbstractUnique properties of amniotic membrane make it a promising source for tissue engineering and a clinically useful alternative for patients suffering from chronic wounds including, for example, ulcers, burns, ocular surface damages and wounds occurring in the course of bullous diseases like stevens‐johnson syndrome and toxic epidermal necrolysis. Its use has many advantages over standard wound care, as it contains pluripotent cells, nutrients, anti‐fibrotic and anti‐inflammatory cytokines, growth factors and extracellular matrix (ECM) proteins. Placental tissues can be prepared as a medical component, an advanced therapy medicinal product or a tissue graft. In addition to basic preparation procedures such as washing, rinsing, cutting, drying and sterilisation, there are many optional steps such as perforation, crosslinking and decellularisation. Finally, transplants should be properly stored—in cryopreserved or dehydrated form. In recent years, many studies including basic science and clinical trials have proven the potential to expand the use of amniotic membrane and amnion‐derived cells to the fields of orthopaedics, dentistry, surgery, urology, vascular tissue engineering and even oncology. In this review, we discuss the role of placental tissues in skin wound healing and in the treatment of various diseases, with particular emphasis on bullous diseases. We also describe some patented procedures for placental tissue grafts preparation.