bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Atorvastatin on ADMA Level and Erectile Function in patients with Vasculogenic Erectile Dysfunction
Authors: Emam A , Abdallah M , Khalil M 
Published: May 2020

Abstract

Background
Erectile dysfunction (ED), the inability to achieve and/or maintain an erection sufficient to permit satisfactory intercourse, is a highly prevalent disease whose aetiology is mostly vasculogenic. It is associated with subclinical coronary artery disease (CAD) and is nowadays considered a marker of future cardiovascular events. The higher prevalence of ED in patients with cardiovascular risk factors(CVRF) reflects the underlying endothelial dysfunction.
ADMA is a naturally occurring amino acid that exists as a result of proteolysis of methylated proteins. Several factors, such as oxidative stress and increased levels of low-density lipoproteins (LDLs), are responsible for induced production of ADMA in endothelial cells.
In our study, atorvastatin administration resulted in a significant decrease in ADMA levels and improvement of erectile function

Aim
To demonstratethe effect of Atorvastatin on ADMA level and erectile function in patients with normal or high LDL level vasculogenic erectile dysfunction.

Patients and Methods
The study will include 30 patients aged 30-60 years old with vasculogenic erectile dysfunction.The patients will be collected from The Andrology Outpatient Clinic – Ain-Shams University Hospitals.

Results
Among the study group 10 subjects showed moderate elevation of plasma ADMA (33.3%), 10 subjects with high level (33.3%) and 10 subjects with normal level (33.3%), while in control group only 5 subjects had high ADMA level, one subjects with moderate elevation and 24 subjects had normal level (80%)
There was high significant reduction in both ADMA and LDL level after atorvastatin treatment and significant improvement in IIEF score, However no significant change in Testosterone level
CONCLUSIONS
We demonstrated that short-term treatment with atorvastatin has great influence on plasma ADMA levels with marked improvement in lipid profile (LDL) and erectile function in both normolipidemic and dyslipidenic patients.
Pathological Role of Biofilm in Fungal Rhinosinusitis
Authors: Ezzat W F , Askoura A M , Elshazly A N , Falah H Y 
Published: May 2020

Abstract

Background
The first case of fungal sinusitis was reported in 1885. This fungal disease occurred rarely until the past decade, when a worldwide increase in its incidence occurred. Till one decade back bacteria was implicated as pathogen in most form of chronic rhinosinusitis (CRS). Fungi were thought to be responsible for few specific forms, sine 1999, when ponikau and associates claimed that fungi were responsible for nearly all cases of CRS. Their study demonstrated the presence of fungi & eosinophils from nose & paranasal sinuses from ∼96 % cases of CRS.

Aim of the Work
The aim of the work was to detect the presence of fungal biofilm, in patients with fungal sinusitis trying to find its role in recurrence of fungal sinus infection, resistance to medical treatment and occurrence of intra orbital and intracranial complications.

Patients and Methods
The study consisted of 20 different cases of fungal sinusitis controlled by 10 cases of non fungal sinusitis. Control cases were divided into 5 cases of chronic sinusitis with nasal polyposis and 5 cases of deviated septum with no evidence of sinusitis undergoing nasal surgery.

Results
Using statistical analysis, there was evidence of pressure of fungal biofilm in different cases of fungal sinusitis whether primary or recurrent, also whether invasive or non invasive. Comparing cases with controls, There was statistically significant difference between them as regard Biofilm (p-value: &lt; 0.001) with incidence reaching (70 %) in cases while (0%) in controls. By applying risk analysis for biofilm, we used relative risk (p value = 0.0001) which is statistically significant indicating higher risk of positive biofilm in cases of fungal sinusitis, also by Using odds ratio (p value= 0.0002) which is statistically significant indicating higher risk of positive biofilm in cases of fungal sinusitis.

Conclusion
The study showed the presence of fungal biofilm in different cases of fungal siunsitis whether primary or recurrent, also whether invasive or non invasive.
Early versus delayed oral feeding post total laryngectomy and relation to trachea-oesophageal fistula formation
Authors: Elibiary H A , Aboelezz T A , Mady O M , Keshk A O T 
Published: May 2020

Abstract

Background
total laryngectomy is the most common procedure in treatment of advanced laryngeal malignant tumors. Total laryngectomy although an important and reliable method of management, still carries a lot of short term and long term complications. One of the common complications is the pharyngocutaneous fistula. Being a major risk factor of longer hospital stay, morbidity and wound infection. Pharyngocutaneous fistula is studied carefully concerning causes, risk factors and management. Oral feeding and voice rehabilitation are two valuable outcomes for the patient. Both could be disturbed by occurrence of pharyngocutaneous fistula. Oral feeding usually starts by the seventh to tenth day postoperative to allow adequate time for pharyngeal closure as believed by many surgeons for decades. Recent studies including our study discuss the possibility of early oral feeding versus conventional delayed feeding and its advantages regarding hospital stay and incidence of fistula.

Aim
The aim of this study is to points out the rate of pharyngocutaneous fistulae incidence after total laryngectomy in two different groups of patients depending on timing of post-operative oral feeding. Oral feeding usually starts after 7-10 days of surgery to allow for complete healing and closure of pharyngeal repair.

Methodology
A meta-analysis study is done to assess the feasibility and the possibility of early oral feeding after total laryngectomy versus delayed oral feeding. The outcome is the occurrence of pharyngocutaneous fistula in each group.

Results
In all included studies the incidence of pharyngocutaneous fistula was 168/1374 (12.23%) in early feeding group versus 69/570 (12.11%) in the delayed feeding group. The statistical difference was insignificant P &gt; 0.05

Conclusion
Early oral feeding after total laryngectomy during the first 72 hours post-operative is a safe clinical practice and results in shorter hospital stay.
Effectiveness of Hypoglossal Nerve Stimulation in the Treatment of Obstructive Sleep Apnea (Meta-analytic Study)
Authors: Mahmoud M , Mohamed A , Mohamed A , Nasr H 
Published: May 2020

Abstract

Background
Obstructive sleep apnea (OSA) is a serious, potentially life-threatening disorder. There are many treatment modalities are being used, but none of them gained consensus. Continuous positive airway pressure considered the most widely accepted treatment of OSA but very poor adherence limits its effectiveness, thus was the need for alternative therapy of high compliance and effective for long term.

Aim of the Work
To perform a meta-analysis of the available studies included outcomes of hypoglossal nerve stimulation to evaluate its effectiveness as a choice of treatment of obstructive sleep apnea.

Patients and Methods
The study included published medical articles that evaluated the efficacy of hypoglossal nerve stimulation as treatment of obstructive sleep apnea with outcomes for primary outcome measures apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and for secondary outcome measures Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ) before and after implantation.

Results
Eight prospective studies with 329 patients were included in this met analysis. At 12 months, statistical analysis demonstrated significant reductions in AHI, ODI with standardized mean difference of -1.3940 (95% CI: -1.7745 to -1.0136; P = 0.0042), -0.9188 (95% CI: -1.3040 to -0.5337; p = 0.0002) respectively, and -not significant- reduction in ESS, FOSQ with standardized mean difference of -1.0365 (95% CI: -1.1889 to -0.8841; p = 0.2290), 1.0545 (95% CI: 0.8867 to 1.2223; p = 0.4922), respectively. Similar were observed at 6 months.

Conclusion
Hypoglossal nerve stimulation results in significant improvement of primary outcome measures of OSA with significant reduction of apnea episodes. It could be considered as an effective -but still of high cost- alternative for OSA patients. Further studies comparing HNS to other therapies are needed.
Acoustic Change Complex (ACC) using Speech and Non-Speech Stimuli in Normal Hearing Children
Authors: Elkholy W A , Hassan D M , Shafik N A , Eltoukhy Y E K 
Published: May 2020

Abstract

Background
Cortical auditory evoked potentials (CAEPs) are brain responses evoked by sound and are processed in or near the auditory cortex. ACC is a cortical auditory evoked potential (P1-N1-P2) elicited by a change within an ongoing sound stimulus.

Objective
To reach the best stimuli that can elicit ACC and act as an objective tool for assessment of cortical auditory discrimination in normal hearing children.

Patients and Methods
The present study was originally designed to standardize ACC evoked response in 41 children aged from 2 to 10 years. The mean age in our study group was 6.2 years with no significant difference between males and females. Stimuli used in this study were specifically designed to be used by AEP equipment that is capable of uploading short duration stimuli (500 msec.), thus can be used in a regular AEP lab. ACC was elicited by three groups of stimuli. Gap-in-tones stimuli represent temporal change (6, 10, 30 and 50 msec. gap introduced to 1000 Hz tone separately), frequency pairs stimuli represent frequency change (2%, 4%, 10% and 25% change from base freq. 1000 Hz) and vowel pairs stimuli represent spectral change (/i-u/, /u-i/, /i-a/. /a-i/, /u-a/, /a-u/). ACC response parameters were compared when using the different stimuli as regards percent detectability, morphology, latency and amplitude.

Results
Gap-in-tones at 6 msec. and 4% frequency change could elicit ACC response in 100% of subjects. For spectral change, /u-i/ was the highest in eliciting ACC (78%) followed by /i-u/ (68.2%) then /a-i/ (58.5%). ACC had the same morphology of the onset response in the majority of subjects, with longer latency and smaller amplitude. ACC amplitude is a better indicator of cortical discrimination compared to latency because it is consistently affected by magnitude of change.

Conclusion
ACC is a good electrophysiological tool for cortical auditory discrimination for temporal, frequency and spectral change.
Comparison between The Diagnostic Performance of Positron Emission Tomography and Diffusion-Weighted MRI in Detecting Recurrence of Head and Neck Squamous Cell Carcinoma during Post Treatment Follow-up
Authors: Talaat M A , Hakim E K , Taha M S , Rabie T M , Askoura A M , Youssef B G 
Published: May 2020

Abstract

Background
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. (16) Despite aggressive combined-modality treatment regimens, there remains a high percentage (15-50%) of locoregional recurrences.(7) This problem make the clinician to rely on the functional imaging modalities such as Diffusion weighted MRI and Positron Emission Tomography to detect recurrence.

Objective
To perform a meta-analytical study on the comparison between the diagnostic role of DW/MRI and PET/CT scan in detecting recurrence of HNSCC during post-treatment follow-up.

Methods
This meta-analysis was conducted from 1/1/ 1998 to 31/3/2018 . Literature search on PubMed and Google scholar was done to identify randomised controlled trials and comparative studies either prospective or retrospective. MedCalc ver. 18.2 (MedCalc, Ostend, Belgium) was used for data analysis.

Results
Of the eight articles included, The meta-analysis was based on a total of 199 patients. All of them used DW/MRI and 186 of them used PET/CT. Comparative study between the two groups regarding sensitivity, specificity and accuracy revealed; highly significant difference in sensitivity in favor of PET/CT (p &lt; 0.009), significant increase in specificity in favor of DW/MRI (p = 0.048) and no significant difference in accuracy between the two group.

Conclusion
PET/CT scan was found to be more sensitive than DW/MRI while DW/MRI was found to be more specific than PET/CT. Yet both have the same degree of accuracy.
Intracorporeal Suturing of MESH and Peritoneum during TAPP as Substituting for Tackers
Authors: Sabry A A , Ahmed D H , Mohammed O Z A 
Published: May 2020

Abstract

Background
groin hernia repair is considered to be one of the most commonly performed operations by general surgeons however; there is no “gold standard” operation for treatment of inguinal hernias. The optimal surgical approach must be selected individually for the patient, taking into account patient age, hernia size, unilaterality or bilaterality, primary or recurrent status, and type of anesthesia, occupation, and leisure activities.

Aim of the Work
is to compare the outcome results of the laparoscopic total extraperitoneal TEP hernia repair with mesh or the transabdominal preperitoneal repair (TAPP) with mesh to those of open repair with mesh.

Patients and Methods
this is a prospective study conducted on those who are diagnosed to have inguinal hernia (direct, indirect). 40 cases with direct, indirect, unilateral or bilateral inguinal hernia and will be divided into two groups:

Group A
20 cases fixation a mesh with Tackers

. Group B
20 cases fixation a mesh with intracorporeal sutures. The study will be Conducted at Ain Shams University hospitals (El-Demerdash) and other authorized hospitals under supervision of thesis supervisors.

Results
smoking appears to be a risk factor for hernia development since almost 55% of the study group A and 65% of the study group B were smokers, obesity also appears to be a risk factor since BMI was about 30.20± 7.82 among group A and 32.05 ± 5.98 among group B. This is in contrast to age which seems not to be as strongly related.

Conclusion
we found the rate of postoperative early and late complications comparable in both groups. But in the LAP group we were able to discharge them from the hospital faster than the OPEN group, they also resumed full activity early.
Radiofrequency Ablation of the Great Saphenous Vein versus Conventional Surgery in Treatment of Venous Ulcers
Authors: Elazazy H H , Rizk M A , Elsehly M S M 
Published: May 2020

Abstract

Background
Chronic venous disease (CVD) is the most common venous disorder. It is caused by venous hypertension due to either reflux, outflow obstruction or both.

Aim of the Work
To analyze the benefit of Radiofrequency ablation of the great saphenous vein versus conventional surgery in healing of venous ulcers.

Patients and Methods
This randomized controlled clinical trial was conducted in the vascular surgery unit at the study was conducted at Ain Shams University Hospitals and Nasser institute hospital in Cairo under supervision of thesis supervisors with Follow up at 2, 4 and 6 months. The study included 40 patients (20 patient for EVLA & 20 patient for conventional Surgery) suffering from primary varicose veins with venous ulcer. Our range of age was 18-51 years.

Results
The present trial confirmed that both surgery and RFA are highly efficacious. Both resulted in significant decrease in venous ulcer size and improvements in the objective severity of venous disease.

Conclusion
RFA is less time consuming than stripping as regard operation time. As regard hospital stay RFA was done as one day surgery cases as they were done under local anesthesia, in stripping group almost patients discharged on the next day as they had been done under spinal anesthesia.
Round Block Technique Versus Reduction Mammoplasty in Treatment of Early Breast Cancer
Authors: Abdelrahman S A , Reda A A , Guirguis S M , Abdelmoaty K F , Abdelhakim S E 
Published: May 2020

Abstract

Background
Early breast cancer can be defined as the presence of a mobile tumor within the breast with or without associated mobile enlarged lymph nodes, and represents the vast majority of patients who present now with breast cancer. Breast-conserving treatment (BCT) has become the standard treatment in early-stage breast cancer; Its goal is to provide a treatment as effective as mastectomy, with the added benefit of a preserved breast.

Aims
The aim of the study is the comparison between Round block technique and Reduction mammoplasty in management of early breast cancer.

Methodology
This is a prospective controlled clinical study which included 30 patients, who were admitted to Ain Shams University Hospitals, with a diagnosis of early breast cancer T1 or T2, N0 or N1, M0. Patients were subdivided into 2 groups: Group I: This group is composed of 15 patients with early breast cancer (T1 or T2, N0 or N1, MO) underwent\Round block rechnique. Group II: This group is composed of 15 patients with early breast cancer (T1 or T2, N0 or N1, MO) underwent Reduction mammoplasty.

Results
In our study, there was no significant statistical difference between the two groups regarding: patients age, our patients were younger in comparable to other studies as we reported average age 47(30-62 years) and 43 (30-64 years). Family history, as 2(40%) and 1(30%) in first degree family members. Side of the lesion (mass), was in right breast in (53.3%) and (60%) in group (I) (Round block group) and group(II) (Reduction mammoplasty group), respectively. There was a significant difference, between the two groups as regard: Intraoperative blood loss, intraoperative time, hospital stay, postoperative complication and cosmetic outcome

Conclusion
Oncoplastic surgery gives a new tool for the treatment of breast cancer as much larger volume of breast tissue can be excised, and wider surgical margins can be achieved especially for larger tumors with better cosmetic outcome, in which a standard resection can lead to poor cosmetic results and tumor-involved surgical margins. Patients with early breast cancer with medium size breast with no major ptosis that are candidate for Round block technique and reduction mammoplasty, round block technique is better for them as there is less morbidity, less complications so no delay in radiotherapy, better cosmesis, mostly doesn’t need contralateral breast surgery for symmetrization and Reduction mammoplasty needs more surgeon’s experience.
Longevity and infection free survival of permicath
Authors: Abdelsalam H , Mohamed M I , Helal M A 
Published: May 2020

Abstract

Background
A hemodialysis catheter is a small biocompatible tube made of soft flexible material. It is inserted into a patient’s target vein to provide vascular access for hemodialysis. As important as catheter placing and handling guide-lines to prevent infection reporting standards are equally important, as they are the tools to enable us to evaluate our work attitudes, how much are we sticking to the guide-lines, how are we managing our resources, and are we aware of the resources we have or not.

Aim of the Work
to figure the outcome and infection rate related to tunneled-cuffed catheters in patients with ESRD needing dialysis who were submitted to tunneled cuffed catheter placement during the period from May 2017 to April 2018.

Patients and Methods
This retrospective descriptive study was conducted in 35 TTCs patients in the Vascular Surgery department ASU Hospital. Target population included patients of ESRD who were submitted for tunneled cuffed dialysis catheter placement in the Vascular Surgery department ASU Hospital in the period from May 2017 to April 2018.

Results
A total of 35 TCCs were inserted in end-stage renal disease patients for hemodialysis. Total number of catheter days was 6343 days. The primary unassisted patency rates at 6 months and 1 year were 51.4% and 11.4% respectively. Of the 35 cases 19 (54.28% of the total population) reported infection episode. 5 (26.3% of the infected population) TCCs were removed due to a severe episode of BSI, of the removed TCCs 2 (10.5% of the infected population) were died. The TCC bacteraemia rate was 2.186 per 1000 catheter days. The total number of the removed TCCs was 14 (40% of the total population). The reasons for removal were non-patency, infection, and completion of therapy with percentage of 22, 8%, 14.3%, and 2, 9% respectively.

Conclusion
Tunnelled cuffed haemodialysis catheters are vital line of treatment in patients requiring long term haemodialysis especially elderly population with weak vasculature or consumed peripheral accesses in which it is considered an access of choice.
Assessment of Port Site Complication in Laparoscopic Abdominal Surgery
Authors: Gad K H , Elhefny A M M , Gerges W B , Sebaie M S A 
Published: May 2020

Abstract

Background
Rapid expansion in the volume and complexities of laparoscopic surgeries has been accompanied by complications, many of which can be directly attributed to abdominal access with laparoscopic trocars including visceral injury, vascular injuries, air embolism, subcutaneous emphysema, port site infections, incisional hernia and metastasis occurred post operatively.

Objectives
This study aimed to detect the different port site complications encountered in laparoscopic abdominal surgery in terms of incidence and management.

Patients and Methods
This study was conducted in the surgical operating theatre of Ain-Shams University Hospitals (Demerdash and Ain Shams University Specialized Hospital), Cairo, Egypt, from January 2018 till July 2018.

Results
In this study complications occurred in 37 cases out of the 400 cases (Study subjects). The incidence of port site complications in our study was 9.25%. Vessel injury occurred in 19 out of the 400 cases with incidence 4.75%. Port site infection occurred in 11 out of the 400 cases with incidence 2.75%. Visceral injury occurred in 4 out of the 400 cases with incidence 1%. Port site hernia occurred in 3 out of the 400 case with incidence 0.75%.

Conclusion
Study incorporated 400 subjects operated for different indications laparoscopically and patients developing any kind of complications were recorded and analyzed. The results showed 3(0.75%) port site hernias, 11(2.75%) port site infections,19 (4.75%) vessel injury, 4 (1%) visceral injury and no port site metastasis was detected.