bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factores de riesgo para diabetes gestacional en población obstétrica en tres instituciones de Medellín, Colombia. Estudio de casos y controles
Authors: Campo-Campo María Nazareth , Posada-Estrada Guadalupe , Betancur-Bermúdez Laura Catalina , Jaramillo-Quiceno Diana Milena 
Published: December 2019

Objetivo: evaluar los factores de riesgo (FR) para diabetes mellitus gestacional en una población obstétrica en Colombia.Materiales y métodos: estudio de casos y controles retrospectivo. Población de mujeres gestantes atendidas en tres clínicas privadas de alta complejidad que atienden población del régimen contributivo de la ciudad de Medellín, en el periodo de junio de 2005 a mayo de 2007. Se excluyeron pacientes con diabetes pregestacional. Se definió como caso: pacientes gestantes o en posparto inmediato con diagnóstico de DMG. Los controles: pacientes en posparto sin DMG. Tamaño muestral: 215 casos y 430 controles. Con base en un OR estimado de 2,3. Relación 2 controles:1 caso, con proporción de exposición entre los controles de 7%, confianza de 95%, poder 80%.Resultados: se incluyeron 244 casos (36,6%) y 423 controles (63,4%). Se encontró asociación estadística con el antecedente personal de DMG (OR = 16,6; IC 95%: 4,9-55,7), el antecedente de macrosomía (OR = 7,3; IC 95%: 3,6-15,1), la edad ≥ 25 años (OR = 5,5; IC 95%: 3,6-8,5), multiparidad (OR = 2,6; IC 95%: 1,8-3,8), el IMC previo a la gestación ≥ 25 kg/m² (OR = 3,1; IC 95%: 2,2-4,4) e IMC al inicio del segundo trimestre ≥ 25 kg/m² (OR = 3,5; IC 95%: 2,1-5,7).Conclusión: además de los factores de riesgo re portados en la literatura, se encontró la macrosomía, la multiparidad, y la obesidad pregestacional y ges tacional como factores independientes para DMG.
Prevalencia del desorden de deseo sexual hipoactivo en mujeres Colombianas y factores asociados
Authors: Raigosa-Londoño Germán , Echeverri-Ramírez Martha Cecilia 
Published: December 2019

Objetivo: medir la prevalencia del desorden de deseo sexual hipoactivo (DDSH) en una muestra de mujeres sexualmente activas con edades entre 15 y 59 años en Colombia, y explorar posibles factores asociados.Materiales y métodos: estudio de corte transversal. Se incluyeron mujeres colombianas entre 15 y 59 años, con vida sexualmente activa. Estas mujeres no son una muestra clínica sino de grupos de mujeres entrevistados de la población general. Criterios de exclusión: analfabetismo y enfermedad sistémica. El tamaño muestral mínimo estimado fue de 369 mujeres, para una prevalencia de 35% con un error máximo de 5% y con 95% de confianza. Muestreo por conveniencia. El cuestionario Female Sexual Function Index (FSFI), validado previamente al español, fue administrado a 567 mujeres sexual-mente activas en varios grupos focales. Se usó un valor de corte de 5 en la escala del deseo para definir DDSH. Se evaluaron además edad, nivel educativo, nivel socioecónomico, estado marital, cohabitación, sentimientos de depresión, uso de drogas antidepresivas, ciclo menstrual, número de hijos y método anticonceptivo. Se calculó la frecuencia relativa en las variables. Para evaluar la asociación entre las variables y la presencia del desorden de deseo sexual hipoactivo se utilizó la razón de Odds (OR) y su respectivo intervalo de confianza.Resultados: en el grupo de estudio 101 de 497 mujeres tuvieron un puntaje menor de 5 para una prevalencia de desorden de deseo sexual hipoactivo de 20,3%. Las variables asociadas fueron: bajo nivel educativo (OR = 2,77; IC 95%: 1,1-6,5), número de hijos (OR = 3; IC 95%: 1,8-5,1), edad mayor de 50 (OR = 3,19; IC 95%: 1-9,4), falta de cercanía emocional con la pareja (OR = 5; IC 95%: 3-8,3), sentimientos de depresión (OR = 1,9; IC 95%: 1,2-2,9) y el uso de antidepresivos (OR = 5; IC 95%: 3-8,3).Conclusiones: un importante porcentaje de la población en Colombia presenta puntajes bajos en el FSFI, sugestivos de desorden de deseo sexual hipoactivo.
Misoprostol intravaginal administrado ambulatoriamente para inducción selectiva del trabajo de parto en pacientes con embarazo a término. Estudio de cohorte
Authors: Moreno-Escallón Bernardo 
Published: December 2019

Objetivos: analizar la respuesta a una dosis intravaginal de misoprostol administrada ambulatoriamente en pacientes embarazadas a término y de bajo riesgo, con deseos de una inducción selectiva del trabajo de parto.Materiales y métodos: cohorte descriptiva realizada en 373 pacientes con embarazos de 38 o más semanas, de bajo riesgo y sin una indicación médica específica, con el deseo de la paciente de finalizar su embarazo quienes recibieron una dosis inicial de 50 mcg de misoprostol intravaginal en forma ambulatoria. Se tomaron los tiempos entre la colocación del misoprostol, la iniciación del trabajo de parto, la hora de hospitalización y del parto. El trabajo de parto fue monitorizado y se evaluó la actividad uterina para detectar polisistolia o hiperestimulación uterina y estado fetal. Se evaluó el tipo de parto, el recién nacido, la necesidad de traslado a la unidad de neonatología y complicaciones maternas.Resultados: se obtuvo respuesta exitosa con dosis única de misoprostol de 50 mcg en 308 pacientes (85,3%). La tasa total de éxito teniendo en cuenta todas las dosis de 50 mcg fue del 98,9%. El 88,3% presentó su parto dentro de las primeras 24 horas de haber sido inducidas. El 91,7% de los casos fueron partos vaginales (74,8% eutócicos y 16,9% instrumentados), y el porcentaje de cesárea fue del 8,3%. El 97,3% de los RN tuvieron un puntaje de Apgar de 7 o más al minuto, y el 100% de 8 o más a los 5 minutos. No hubo complicaciones maternas.Conclusiones: el uso ambulatorio del misoprostol surge como alternativa para la inducción del trabajo del parto por su efectividad y seguridad. Aunque este no es un estudio controlado, los resultados señalan un beneficio importante del misoprostol ambulatorio, que convendría confirmar con estudios aleatorizados.
Genome-wide systematic characterization of HAK/KUP/KT gene family and their expression profiles during plant growth and in response to low K+ stress in Saccharum
Authors: Feng Xiaomin , Wang Yongjun , Zhang Nannan , Wu Zilin , Zeng Qiaoying , Wu Jiayun , Wu Xiaobin , Wang Lei , Zhang Jisen , Qi Yongwen 
Published: December 2019

Abstract
Background: Plant genomes contain large number of HAK/KUP/KT transporters, and they play important roles in potassium uptake and translocation, osmotic potential regulation, salt tolerance, root morphogenesis and plant development. Potassium deficiency in soil of sugarcane main planting area is serious. However, the HAK/KUP/KT gene family remains to be characterized in sugarcane (Saccharum). Results: In this study, 30 HAK/KUP/KT genes were identified from Saccharum spontaneum. Phylogenetics, duplication events, gene structure and expression pattern were analyzed. Phylogenetic analysis of HAK/KUP/KT genes from 15 representative plants showed that this gene family were divided into four groups (clade I-IV). Both ancient whole-genome duplication (WGD) and recent gene duplication contributed to the expansion of HAK/KUP/KT gene family. Nonsynonymous to synonymous substitution ratio (Ka/Ks) analysis showed that purifying selection was the main force to drive the evolution of HAK/KUP/KT genes. The divergence time of HAK/KUP/KT gene family was estimated to range from 134.8 to 233.7 Mya based on Ks analysis, suggesting that it is an ancient gene family in plants. Gene structure analysis showed that HAK/KUP/KT genes was accompanied by intron gain/loss in the process of evolution. RNA-seq data analysis demonstrated that HAK/KUP/KT genes from clade II and III mainly displayed constitutive expression in various tissues, while most genes from clade I and IV had no or very low expression in the tested tissues at different developmental stages. SsHAK1 and SsHAK21 displayed upregulated expression in response to low K+ stress. Yeast functional complementation analysis suggested that SsHAK1 and SsHAK21 could rescue K+ uptake ability in the yeast mutant. Conclusions: This study provided insight into the gene evolutionary history of HAK/KUP/KT genes. HAK7/9/18 were mainly expressed in the high photosynthetic zone and mature zone of stem. Moreover HAK7/9/18/25 were regulated by sunlight. SsHAK1 and SsHAK21 played important role in mediating potassium acquisition under limited K+ supply. Our results provide valuable information and key candidate genes for further study on the function of HAK/KUP/KT genes in Saccharum. Keywords: Saccharum, HAK/KUP/KT, evolution, gene expression, low K+ stress
Towards a progression of health literacy skills: Establishing the HLS-Q12 cutoff scores
Authors: Guttersrud Øystein , Le Christopher , Pettersen Kjell Sverre , Helseth Sølvi , Finbråten Hanne Søberg 
Published: December 2019

Abstract
Background The self-reported European Health Literacy Survey Questionnaire (HLS-EU-Q47) is a widely used measure for population health literacy. Based on confirmatory factor analyses and Rasch modelling, the short form HLS-Q12 was developed to meet the Rasch unidimensional measurement model expectations. After its publication, there was a worldwide call to identify HLS-Q12 cutoff scores and establish clearly delineated standards regarding the skills assessed. This study therefore aims to identify the HLS-Q12 scores associated with statistically distinct levels of proficiency and to construct a proficiency scale that may indicate what individuals typically know and can do at increasingly sophisticated levels of health literacy. Methods We applied the unidimensional Rasch measurement model for polytomous items to responses from 900 randomly sampled individuals and 388 individuals with type 2 diabetes. Using Rasch based item calibration, we constructed a proficiency scale by locating the ordered item thresholds along the scale. By applying Wright’s method for the maximum number of strata, we determined the cutoff scores for significantly different levels. By directly referring to item content that people who achieved the cutoff scores viewed as ‘easy’, we suggested what these gradually more advanced levels of health literacy might mean in terms of item content. Results Analysing the population sample, we identified statistically distinct levels of health literacy at the empirically identified cutoff scores 27, 33 and 39. We confirmed them by analysing the responses from individuals with diabetes. Using item calibration, the resulting HLS-Q12 proficiency scale expresses typical knowledge and skills at these three statistically distinct levels. The scale’s cumulative nature indicates what it may mean qualitatively to move from low to high health literacy. Conclusions By identifying levels of health literacy, we may initiate the improvement of current models of health literacy. Determining how to adapt information to patients’ health literacy level is a possible clinical outcome. A substantial methodological outcome is the inevitability of Rasch modelling in measurement. We found that Wright’s method identified rating scale cutoff scores consistently across independent samples. To reveal sources of potential biases, threats to validity and imprecision of benchmarks, replication of our study in other contexts is required
Risk of multi-drug resistant Campylobacter spp. and residual antimicrobials at poultry farms and live bird markets in Bangladesh
Authors: Neogi Sucharit Basu , Islam Md. Mehedul , Islam SK Shaheenur , Akhter A.H.M. Taslima , Sikder Md. Mahmudul Hasan , Yamasaki Shinji , Kabir S. M. Lutful 
Published: December 2019

Abstract
Background: Understanding potential risks of multi-drug resistant (MDR) pathogens from the booming poultry sector is a crucial public health concern. Campylobacter spp. are among the most important zoonotic pathogens associated with MDR infections in poultry and human. This study systematically examined potential risks and associated socio-environmental factors of MDR Campylobacter spp. in poultry farms and live bird markets (LBMs) of Bangladesh. Methods: Microbial culture and PCR-based methods were applied to examine the occurrence and MDR patterns of Campylobacter spp. at hatcheries (n = 33), broiler farms (n = 122) and LBMs (n = 69). Antimicrobial residues in broiler meat and liver samples (n = 50) were detected by advanced chromatographic techniques. A questionnaire based cross-sectional survey was conducted on socio-environmental factors. Results: In poultry farms, Campylobacter spp. was primarily found in broiler cloacal swab (21/49, 43%), followed by drinking water (8/24, 33%), and meat (8/28, 29%) samples of broilers. Remarkably, in live bird markets, Campylobacter spp. was detected in higher prevalence in broiler meat (14/26, 54%), which could have an association with bacterial contamination in drinking water (11/21, 52%) and floor (9/21, 43%). Representative isolates (n = 71) were differentiated into two species: Campylobacter jejuni (66%) and Campylobacter coli (34%). Majority of C. jejuni (33/47, 70%) and C. coli (14/24, 58%) strains were observed to be MDR, showing resistance to amoxycilin, tetracycline and erythromycin, and additionally ciprofloxacin, norfloxacin, streptomycin, and azithromycin. Residual antimicrobials, including oxytetracycline, ciprofloxacin and enrofloxacin, were detected in majority of broiler liver (79%) and meat (62%) samples. Alarmingly, 33% and 19% of the liver and meat samples, respectively, contained residual antimicrobial concentration above acceptable limit. Inadequate personal and environmental hygiene, unscrupulously use of antimicrobials, improper waste disposal, and lack of health surveillance and quarantine facilities of diseased birds were distinguishable risk factors, with local diversity and compound influences on MDR pathogens. Conclusion: Potential contamination sources and anthropogenic risk factors associated with the alarming occurrence of MDR Campylobacter, noted in this study, would aid in developing interventions to minimize the increasing risks of poultry-associated MDR pathogens under ‘One Health’ banner that includes poultry, human and environment perspectives.
Patients’ Satisfaction with Clinical Laboratory Services in Public Hospitals in Ethiopia
Authors: Hailu Hiwot Amare , Lule Adinew Desale , Yalew Anteneh , Alaba Habtamu Asrat , Kebede Sisay , Dejene Daniel , Gebremicheal Hiwot Abebe , Gashu Andargachew , Yenealem Dereje , Ejigu Birhan Moges , Woldeamanuele Nebiyou Yemanebrhane , Desalegn Daniel Melese , Gurmessa Ashebir , Mohammed Awad , Getu Zekaryas , Ayana Gonfa , Anbessa Adisu Kebede , Abate Ebba 
Published: December 2019

Abstract
Background: Knowing customers’ level of satisfaction is relevant to improve and provide quality health care services. In the clinical laboratory, monitoring customers’ satisfaction is an important indicator of the quality management system and required by international laboratory standards. However, in Ethiopia, there has not been baseline data about the satisfaction level of patients’ with laboratory services at the national level. The aim of this national level survey was to assess patients’ satisfaction level with laboratory services at public hospitals in Ethiopia. Methods: A national survey was conducted using an institutional based cross-sectional study design was employed from 01 to 30 November 2017. A total of 2,399 patients were selected randomly from 60 public hospitals. Data was collected using structured questionnaire, entered in Epi Info and analyzed with SPSS software. Multiple logistic regression model was fitted to identify predictors of patients’ satisfaction with laboratory services. A p-value of less than 0.05 was taken as statistically significant. Result: Overall, 78.6% of the patients were satisfied with the clinical laboratory services. Patients were dissatisfied with cleanness of latrine (47%), long waiting time (30%), clear and understandable advisory service during specimen collection (26%), adequacy of waiting area (25%), easy accessibility of laboratory (19%) and latrine location (20%), availability of requested service (18%), unfair payment of service (17%) and missing of result (12%). The educational status (P = 0.032), and distance (P = 0.000) were significantly associated with client overall satisfaction level. Conclusion: Most laboratory patients’ were satisfied with the service provided by public hospital laboratories in public hospitals in Ethiopia. However, patients’ were dissatisfied with the accessibility of sites, adequacy of waiting area, cleanness of latrine, long TAT, communication, missing of results, availability of requested service and cost of service. Therefore, responsible bodies in each level should act on the identified gaps and improve the need of patients in each hospital laboratory. In addition, all hospital laboratories should conduct a satisfaction survey and meet the needs of laboratory patients. Keywords: patient satisfaction, hospital, laboratory service, national survey
Nurses’ knowledge of pressure ulcer and its associated factors at Hawassa University Comprehensive Specialized Hospital Hawassa, Ethiopia, 2018.
Authors: Muhammed Ezedin Molla , Bifftu Berhanu Boru , Temachu Yemataw Zewdu , Walle Tarkie Abebe 
Published: December 2019

Abstract
Background: Pressure ulcer is largely avoidable, but its prevalence rate increased more than 80% in a thirteen years study. Nurses have a great position to advance best practices towards the prevention of pressure ulcers. Therefore they should be knowledgeable of the signs and symptoms of pressure ulcers, and preventive strategies to reduce its incidence, but there is limited evidence on nurses’ knowledge and its associated factors to prevent pressure ulcer in Ethiopia.
Objectives: The study aimed to assess nurses' knowledge and associated factors towards pressure ulcer prevention at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia, 2018.
Methods: A hospital-based cross-sectional study was conducted from March 25 – April 23/ 2018. A total of 356 nurses were selected by stratification with a simple random sampling technique. Pretested structured questionnaire with closed and open-ended questions was used to collect data. Frequency distribution and percentage were computed to describe each variable. Bivariate and multivariable logistic regression with a 95% confidence interval was also carried out to see the effect of each independent variable on the dependent variable and declared statistical significant association with P< 0.05.
Result: The mean knowledge score of nurses was 25.22 out of 41 item questions. Fifty-two point five percent of nurses score above the mean. Males [AOR=0.44, 95% CI (0.26 – 0.73)], working a maximum of eight hours [AOR= 3.57, 95% CI (1.48 – 8.61), not having training [(AOR= 2.31, 95% CI (1.14 – 4.61)], Low salary [AOR= 3.47, 95% CI (1.03 – 11.67)] were significantly associated with inadequate knowledge.
Conclusion: Generally a nurse's knowledge of pressure ulcer was inadequate. Being female, working less than or equal to eight hours, not having the training and low working salary are contributors to a low level of knowledge for pressure ulcer.
Keywords: Knowledge, Nurses, Pressure Ulcer Prevention
Association between Severe Unaddressed Dental Needs and Developmental Health at School Entry in Canada: A Cross-Sectional Study
Authors: Janus Magdalena , Reid-Westoby Caroline , Lee Catherine , Brownell Marni , Maguire Jonathon L. 
Published: December 2019

Abstract
Background
Dental problems are the most prevalent chronic disease worldwide, with up to half of all kindergarten children having tooth decay. However, there is a lack of evidence of whether unaddressed dental needs (UDNs) are associated with children’s developmental health, a concept reflecting holistic child development - encompassing physical, emotional, and cognitive development. The objective of the current study was to evaluate the relationship between UDNs and developmental health among kindergarten children using the Early Development Instrument (EDI).
Methods
We examined associations between teacher reported UDNs and developmental vulnerability on the EDI. Children were included in the study if they were enrolled in kindergarten in publicly-funded schools in Canada between 2010 and 2015, had been in the classroom for at least one month, and had no more than 25% of missing items on the questionnaire.
Results
Among 576,264 children who met inclusion criteria (95.4% of eligible children), 2,465 (0.4%) were identified as having UDNs by their teachers. Children with UDNs had 4.58 to 8.27 times higher odds of being vulnerable on any of the five developmental domains (physical health and well-being, social competence, emotional maturity, language and cognitive development, communication skills and general knowledge), compared to children without UDNs.
Conclusion
In this study, teacher-reported UDNs were associated with developmental vulnerability in kindergarten children. Teacher reported unmet dental needs in kindergarten children may be a proxy for poor developmental health at school entry, and thus a marker for supporting both children’s oral health and early developmental needs.
How does a targeted active labour market program impact on the well-being of the unemployed? A Concept Mapping study on Barcelona “Employment in the Neighbourhoods”
Authors: Puig-Barrachina Vanessa , Malmusi Davide , Artazcoz Lucía , Bartoll Xavier , Clotet Eva , Cortés-Franch Imma , Ventura Lorena , Daban Ferran , Díez Èlia , Borrell Carme 
Published: December 2019

Abstract
Background: In 12 neighbourhoods of Barcelona (Spain), an innovative tailor-made Active Labour Market Program called “Employment in the neighbourhoods” was implemented to get people from deprived, high-unemployment neighbourhoods back to work. This study aimed to describe the effects of the program on participants’ quality of life, as well as the mechanisms underlying these effects, according to their own perception and the perception of technical staff by who are assisted.
Methods: We used Concept Mapping, a mixed methods approach that combines qualitative and quantitative analysis to develop a conceptual map of perceptions of program’s participants and technical staff about changes in the participants’ quality of life. Data collection occurred within the generation and structuring steps where participants brainstorm answers to the focus question, and then rate and sort the responses. To compute maps, we used Concept Systems Incorporated software which conducted two main forms of analysis, a multidimensional scaling analysis followed by hierarchical cluster analysis.
Results: Study participants report several positive effects on mental health and emotional wellbeing, including self-esteem and empowerment. The mechanisms identified were strengthened social networks, skills acquisition and emotional coaching and personalized technical assistance. We also identified some negative impacts, mainly related to the labour market situation. We observed marked gender differences in the discourses of program participants.
Conclusions: The results obtained have allowed us to identify different perceived effects and mechanisms by which the “Employment in the Neighbourhoods” Active Labour Market Programme can influence the quality of life of participants from the most deprived areas of Barcelona.