bluuebunny/crossref_metadata_2025_split huggingface dataset:
State Laws and Regulations Addressing Nurse-Initiated Protocols and Use of Nurse-Initiated Protocols in Emergency Departments: A Cross-Sectional Survey Study
Authors: Castner Jessica , Boris Lenore 
Published: September 2020

Introduction State regulations may impede the use of nurse-initiated protocols to begin life-saving treatments when patients arrive to the emergency department. In crowding and small-scale disaster events, this could translate to life and death practice differences. Nevertheless, research demonstrates nurses do utilize nurse-initiated protocols despite legal prohibitions. The purpose of this study was to explore the relationship of the state regulatory environment as expressed in nurse practice acts and interpretive statements prohibiting the use of nurse-initiated protocols with hospital use of nurse-initiated protocols in emergency departments. Methods A cross-sectional approach was used with a nationwide survey. The independent variable categorized the location of the hospital in states that have a protocol prohibition. Outcomes included protocols for blood laboratory tests, X-rays, over-the-counter medication, and electrocardiograms. A second analysis was completed with New York State alone because this state has the strongest language prohibiting nurse-initiated protocols. Results A total of 350 participants returned surveys from 48 states and the District of Columbia. A hospital was more likely to have policies supporting nurse-initiated protocols if they were not in a state with the scope of practice prohibitions. Four categories emerged such as advantages, approval, prohibition, and conditions under which the protocols can be used. Prohibitive language was associated with less protocol use for emergency care. Conclusion State scope of practice inconsistencies create misalignment with emergency nurse education and training, which may impede timely care and contribute to inequalities and inefficiencies in emergency care. In addition, prohibitive language places practicing nurses responding to emergencies in crowded work environments at risk.
A three-miRNA panel in serum as a noninvasive biomarker for colorectal cancer detection
Authors: Peng Xiqi , Wang Jingyao , Zhang Chunduo , Liu Kaihao , Zhao Liwen , Chen Xuan , Huang Guocheng , Lai Yongqing 
Published: September 2020

Background: Circulating miRNAs have been proved to be promising biomarkers for disease detection in recent years. The present study aimed at exploring available serum miRNA biomarkers for the detection of colorectal cancer. Methods: A three-phase study was performed to select and validate candidate miRNAs with significant dysregulation in colorectal cancer using quantitative reverse transcription-polymerase chain reaction. This study recruited 137 colorectal cancer patients and 145 healthy controls. The diagnostic values of miRNAs were evaluated by receiver operating characteristic analysis. Bioinformatics analyses were utilized to predict target genes of miRNAs, and to conduct functional annotation and enrichment. Results: miR-30e-3p, miR-31-5p, miR-34b-3p and miR-146a-5p, miR-148a-3p and miR-192-5p were significantly dysregulated in colorectal cancer serum when compared with healthy controls. The panel composed of miR-30e-3p, miR-146a-5p, and miR-148a-3p exhibited strong diagnostic ability. The area under the receiver operating characteristic curve of the three-miRNA panel was 0.883, with a sensitivity of 0.800 and specificity of 0.787. Conclusion: The present study identified a three-miRNA panel in serum with a strong diagnostic ability of colorectal cancer, which may be able to serve as a novel noninvasive biomarker for colorectal cancer detection.
From Research to Practice: Is Rethinking Architectural Education the Remedy?
Authors: Tvedebrink Tenna Doktor Olsen , Jelić Andrea 
Published: September 2020

Objectives: Our aim is to investigate how a new master studies course “Architecture, Health, and Well-being” (AHW) supports development of students’ skills in understanding and assessing health-related research as well as applying research-based knowledge through unfolding of user perspectives in their design projects. Background: With the growing focus on health-related research in Danish design practice, knowing how to translate research findings into research-informed design strategies becomes a preferable, if not (yet) a critical, skill. This calls for architecture educations to reconsider their graduate profiles and teaching curricula, thereby addressing research-to-practice gap. Method: Based on design project hand-ins, we evaluate whether students participating in the AHW course demonstrate greater sensibility toward user experiences and research-based design (RBD) in their master thesis projects, compared to students attending a more traditional architectural tectonic track. Evaluation relates to the use of scientific literature and theoretical frameworks on topics like “healing architecture” and applied user-oriented methods (interviews, personas, demographics). Results: Our explorative analysis indicates that students have the skills to make a detailed user analysis when it comes to well-defined user groups in a highly specialized building (e.g., hospice patients and staff). The extent to which health-related research and user perspectives are applied in the design process seems to be primarily driven by thematic focus of the project (welfare buildings in contrast to housing). Conclusion: Despite the challenges in teaching students to assess and apply academic literature, a RBD paradigm in architectural education can help bridge emerging research knowledge with design skills and professional competencies.
Evaluating the Relationship Between Olfactory Function and Loneliness in Community-Dwelling Individuals: A Cross-sectional Study
Authors: Desiato Vincent M. , Soler Zachary M. , Nguyen Shaun A. , Salvador Craig , Hill Jonathan B. , Lamira Jensine , Rowan Nicholas R. , Yoo Frederick , Little Ryan E. , Matthews Lois J. , Dubno Judy R. , Schlosser Rodney J. 
Published: September 2020

Background Olfactory dysfunction (OD) has been reported to impact social interactions. However, the relationship between OD and loneliness has received little attention. The purpose of this study was to determine the association between OD and loneliness, controlling for patient factors. Methods Subjects without otolaryngic complaints were enrolled and olfactory function was assessed using: Sniffin’ Sticks test to measure threshold, discrimination and identification (TDI), Questionnaire of Olfactory Disorders Negative Statements (QOD-NS) and 9 – item Olfactory-Visual Analogue Scale (VAS). Loneliness was assessed using the De Jong Gierveld (DJG) and University of California Los Angeles (UCLA) loneliness scales. Bivariate analysis was performed followed by regression analysis, controlling for confounders. Results In total, 221 subjects were included with a mean age of 50.5 years (range 20 to 93), 133 (60.2%) females and 161 (72.9%) white. Mean TDI score was 29.3 (7.0) and 49.5% of the cohort was dysosmic. Using DJG, 36.4% of the cohort were classified as lonely, whereas 35.0% were lonely using UCLA. Olfactory measures were significantly associated with DJG, including TDI (β = −0.03, p = 0.050), olfactory discrimination (β = −0.111, p = 0.005), QOD-NS (β = 0.058, p < 0.001) and olfactory-VAS (β = 0.032, p < 0.001). UCLA scores were significantly associated with QOD-NS (PR 1.061 [CI 1.018–1.107], p = 0.005) and olfactory-VAS scores (PR 1.027, [CI 1.007–1.049], p = 0.009). After controlling for confounders, the association between DJG and olfactory discrimination, as well as DJG and olfactory-VAS remained significant. Conclusions In this community-based sample of older adults, both OD and loneliness were common. Those subjects with worse olfactory function were more likely to report loneliness. Further research is necessary to establish causality, as well as explore the role of depression.
Long-Term Survivorship and Clinical Outcomes of Osteochondral Autologous Transplantation for Steroid-Induced Osteonecrosis of the Knee
Authors: Nishitani Kohei , Nakagawa Yasuaki , Kobayashi Masahiko , Nakamura Shinichiro , Mukai Shogo , Kuriyama Shinichi , Matsuda Shuichi 
Published: September 2020

Objective Treatments for steroid-induced osteonecrosis of the knee remains challenging, and there has not been sufficient evidence to support joint preservation surgery. This study evaluated long-term outcomes of osteochondral autologous transplantation (OAT) for steroid-induced osteonecrosis of the knee. Design This retrospective case series included patients who underwent OAT for steroid-induced osteonecrosis of the knee from 1998 to 2008. The survivorship and need for secondary surgery were evaluated, and the clinical outcome was evaluated with the International Knee Documentation Committee (IKDC) subjective score. Preoperative and final Kellgren-Lawrence (KL) grade of the femorotibial and patellofemoral joints were individually evaluated. Results Fourteen knees of 10 patients whose mean age was 32.5 (95%CI 26.4-38.6) years were included and followed for 14.0 (12.4-15.7) years. The mean lesion size of 6.9 (5.3-8.5) cm2 was repaired using 4 median (minimum 2, maximum 5) osteochondral plugs. No revision surgeries were performed for transplanted osteochondral plugs. The IKDC subjective score improved from 32.9 (24.5-41.3) to 74.2 (61.9-88.5) ( P < 0.001). Knee flexion was improved at the final follow-up, and Seiza sitting was finally possible in 9 knees in 7 patients. Although the osteoarthritic change did not progress in femorotibial joint, patellofemoral joint showed early osteoarthritic changes at the final follow-up (mean KL grade: 0.8 [0.5-1.1]). Conclusions Prosthetic joint replacement was successfully avoided for at least the first decade by OAT in young patients with steroid-induced osteonecrosis of the knee. The progression of KL grade of the patellofemoral joint is of concern.
Performance on the mini-mental state exam and the Montreal cognitive assessment in a sample of old age psychiatric patients
Authors: Korsnes Maria Stylianou 
Published: September 2020

Objective: This study assesses to what extent the Mini-Mental State Exam and the Montreal Cognitive Assessment scores may predict the presence of dementia in a sample of typical old age psychiatric patients who may or may not have temporally or permanently reduced cognitive abilities. Methods: A total of 141 inpatients completed the Mini-Mental State Exam and the Montreal Cognitive Assessment at arrival. All patients were subsequently diagnosed during their stay at the age-psychiatric unit. Receiver operating characteristics and analysis of variance were used to compare the results of the two tests for different patient groups. Results: The Montreal Cognitive Assessment is slightly more sensitive and specific than the Mini-Mental State Exam for dementia prediction. Age, sex, and education only account for approximately 2% of the variance in both tests. Patients with more than one diagnosis across the diagnostic groups included in this study (dementia, psychoses, affective disorder, and depression) performed significantly poorer on both tests than patients with a single diagnosis. Conclusions: Both tests are efficient in detecting cognitive impairment, but neither test can effectively exclude other reasons for low test results in our sample of elderly psychiatric patients. The sensitivity for ruling out dementia is 27 points for the Mini-Mental State Exam and 23 points for the Montreal Cognitive Assessment in the current patient sample.
Evidence-Based Education: The (Not So Simple) Case of French-Speaking Belgium
Authors: Dachet Dylan , Baye Ariane 
Published: September 2020

Purpose: Taking the case of educational reform in French-speaking Belgium (the Pact for Educational Excellence), this article aims to describe the process of integrating evidence-based education (EBE) into an educational reform within a country where the influence of qualitative research is important. Design/Approach/Methods: A narrative case study was conducted to analyze and understand the stages of the ongoing educational reform process and the successive involvements of our research center in the work of this reform. Inspired by the paradigm of EBE, we initiated both the consultation processes intended to set the direction of educational decisions and programs. Findings: According to Slavin (2017, 2019), providing educator-friendly reviews, making available a broad range of proven education programs, and providing resources to help schools to implement proven programs are levers for implementing evidence-based reform within an educational system. This article shows that one of the three levers is fully met. For the other two, work being done on EBE in the U.S. and the UK in particular can save us time. Originality/Value: This article highlights concrete actions that will ensure the gradual establishment and acceptance by political and educational actors of an evidence-based reform.
Rare earth mineral diversity controlled by REE pattern shapes
Authors: Anenburg Michael 
Published: September 2020

AbstractThe line connecting rare earth elements (REE) in chondrite-normalised plots can be represented by a smooth polynomial function using λ shape coefficients as described by O'Neill (2016). In this study, computationally generated λ combinations are used to construct artificial chondrite-normalised REE patterns that encompass most REE patterns likely to occur in natural materials. The dominant REE per pattern is identified, which would lead to its inclusion in a hypothetical mineral suffix, had this mineral contained essential REE. Furthermore, negative Ce and Y anomalies, common in natural minerals, are considered in the modelled REE patterns to investigate the effect of their exclusion on the relative abundance of the remainder REE. The dominant REE in a mineral results from distinct pattern shapes requiring specific fractionation processes, thus providing information on its genesis. Minerals dominated by heavy lanthanides are rare or non-existent, even though the present analysis shows that REE patterns dominated by Gd, Dy, Er and Yb are geologically plausible. This discrepancy is caused by the inclusion of Y, which dominates heavy REE budgets, in mineral name suffixes. The focus on Y obscures heavy lanthanide mineral diversity and can lead to various fractionation processes to be overlooked. Samarium dominant minerals are known, even though deemed unlikely by the computational model, suggesting additional fractionation processes that are not well described by λ shape coefficients. Positive Eu anomalies only need to be moderate in minerals depleted in the light REE for Eu to be the dominant REE, thus identifying candidate rocks in which the first Eu dominant mineral might be found. Here, I present an online tool, called ALambdaR that allows interactive control of λ shape coefficients and visualisation of resulting REE patterns.
Amino acid depletion triggered by ʟ-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death
Authors: Soncini Debora , Minetto Paola , Martinuzzi Claudia , Becherini Pamela , Fenu Valeria , Guolo Fabio , Todoerti Katia , Calice Giovanni , Contini Paola , Miglino Maurizio , Rivoli Giulia , Aquino Sara , Dominietto Alida , Cagnetta Antonia , Passalacqua Mario , Bruzzone Santina , Nencioni Alessio , Zucchetti Massimo , Ceruti Tommaso , Neri Antonino , Lemoli Roberto M. , Cea Michele 
Published: September 2020

Abstract
Metabolic reprogramming is emerging as a cancer vulnerability that could be therapeutically exploitable using different approaches, including amino acid depletion for those tumors that rely on exogenous amino acids for their maintenance. ʟ-Asparaginase (ASNase) has contributed to a significant improvement in acute lymphoblastic leukemia outcomes; however, toxicity and resistance limit its clinical use in other tumors. Here, we report that, in multiple myeloma (MM) cells, the DNA methylation status is significantly associated with reduced expression of ASNase-related gene signatures, thus suggesting ASNase sensitivity for this tumor. Therefore, we tested the effects of ASNase purified from Erwinia chrysanthemi (Erw-ASNase), combined with the next-generation proteasome inhibitor (PI) carfilzomib. We observed an impressive synergistic effect on MM cells, whereas normal peripheral blood mononuclear cells were not affected. Importantly, this effect was associated with increased reactive oxygen species (ROS) generation, compounded mitochondrial damage, and Nrf2 upregulation, regardless of the c-Myc oncogenic-specific program. Furthermore, the cotreatment resulted in genomic instability and DNA repair mechanism impairment via increased mitochondrial oxidative stress, which further enhanced its antitumor activity. Interestingly, carfilzomib-resistant cells were found to be highly dependent on amino acid starvation, as reflected by their higher sensitivity to Erw-ASNase treatment compared with isogenic cells. Overall, by affecting several cellular programs, Erw-ASNase makes MM cells more vulnerable to carfilzomib, providing proof of concept for clinical use of this combination as a novel strategy to enhance PI sensitivity in MM patients.
A Novel Ni-Free Zr-Based Bulk Metallic Glass with High Glass Forming Ability, Corrosion Resistance and Thermal Stability
Authors: Luo Yu , Jiang Yidong , Zhang Pei , Wang Xin , Ke Haibo , Zhang Pengcheng 
Published: September 2020

AbstractZr-based Bulk metallic glasses exhibit incredible corrosion resistance and glass forming ability, however, these properties need further enhancement to meet the practical use. In this study, Zr63Fe2.5Cu23Al11.5, a new type of Zr-based bulk metallic glass was fabricated. Potentiodynamic polarization techniques were used to measure the corrosion resistance of this alloy. Furthermore, crystallization behavior and kinetics of Zr63Fe2.5Cu23Al11.5 bulk metallic glass were investigated by using differential scanning calorimetry of non-isothermal model. Kissinger and Ozawa methods were used for calculating activation energies of crystallization and the mechanism of crystallization was analyzed by Johnson-Mehl-Avrami-Kolmogorow methods. The results suggest that this specified metallic glass system possesses a relatively high thermal stability and glass forming ability. Moreover, the crystallization procedure is mainly dominated by nucleation with an increasing rate. The study demonstrates that the slight composition adjustment of Zr–Fe–Cu–Al system bulk metallic glass can make a considerable contribution to higher glass forming and thermal stability as well as corrosion resistance.
Color change and termite resistance of fast-growing tropical woods treated with kesambi (Schleichera oleosa) smoke
Authors: Hadi Yusuf Sudo , Massijaya Muh Yusram , Nandika Dodi , Arsyad Wa Ode Muliastuty , Abdillah Imam Busyra , Setiono Loedy , Amin Yahya 
Published: September 2020

AbstractSmoke treatment can be used to enhance wood resistance to subterranean termite attack. In this study, kesambi (Schleichera oleosa) wood was pyrolyzed to produce charcoal. The smoke produced as a by-product of pyrolysis was used to treat sengon (Falcataria moluccana), jabon (Anthocephalus cadamba), mangium (Acacia mangium), and pine (Pinus merkusii) wood samples for 1, 2, or 3 weeks. Following the smoke treatment, the wood specimens were exposed to subterranean termites (Coptotermes curvignathusHolmgren) according to the Indonesian standard 7207-2014 in a laboratory. The color change caused by smoke treatment was observed, and chemical analysis of smoke was also done. The results showed that chemical compounds of kesambi smoke predominantly consisted of acetic acid, phenol, ketones, amines, and benzene. The color of smoked wood became darker, less yellow, and a little redder, while a longer smoking period produced a darker color which was more resistant to termite attack. Smoke treatment enhanced the resistance of wood to subterranean termite attack, and the resistance levels were not significantly different based on the duration of the smoke treatment.
Pilea umbrosa ameliorate CCl4 induced hepatic injuries by regulating endoplasmic reticulum stress, pro-inflammatory and fibrosis genes in rat
Authors: Naz Irum , Khan Muhammad Rashid , Zai Jawaid Ahmed , Batool Riffat , Zahra Zartash , Tahir Aemin 
Published: September 2020

Abstract
Background
Pilea umbrosa (Urticaceae) is used by local communities (district Abbotabad) for liver disorders, as anticancer, in rheumatism and in skin disorders.

Methods
Methanol extract of P. umbrosa (PUM) was investigated for the presence of polyphenolic constituents by HPLC-DAD analysis. PUM (150 mg/kg and 300 mg/kg) was administered on alternate days for eight weeks in rats exposed with carbon tetrachloride (CCl4). Serum analysis was performed for liver function tests while in liver tissues level of antioxidant enzymes and biochemical markers were also studied. In addition, semi quantitative estimation of antioxidant genes, endoplasmic reticulum (ER) induced stress markers, pro-inflammatory cytokines and fibrosis related genes were carried out on liver tissues by RT-PCR analysis. Liver tissues were also studied for histopathological injuries.

Results
Level of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), peroxidase (POD) and glutathione (GSH) decreased (p < 0.05) whereas level of thiobarbituric acid reactive substance (TBARS), H2O2 and nitrite increased in liver tissues of CCl4 treated rat. Likewise increase in the level of serum markers; alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and total bilirubin was observed. Moreover, CCl4 caused many fold increase in expression of ER stress markers; glucose regulated protein (GRP-78), x-box binding protein1-total (XBP-1 t), x-box binding protein1-unspliced (XBP-1 u) and x-box binding protein1-spliced (XBP-1 s). The level of inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) was aggregated whereas suppressed the level of antioxidant enzymes; γ-glutamylcysteine ligase (GCLC), protein disulfide isomerase (PDI) and nuclear erythroid 2 p45-related factor 2 (Nrf-2). Additionally, level of fibrosis markers; transforming growth factor-β (TGF-β), Smad-3 and collagen type 1 (Col1-α) increased with CCl4 induced liver toxicity. Histopathological scrutiny depicted damaged liver cells, neutrophils infiltration and dilated sinusoids in CCl4 intoxicated rats. PUM was enriched with rutin, catechin, caffeic acid and apigenin as evidenced by HPLC analysis. Simultaneous administration of PUM and CCl4 in rats retrieved the normal expression of these markers and prevented hepatic injuries.

Conclusion
Collectively these results suggest that PUM constituted of strong antioxidant chemicals and could be a potential therapeutic agent for stress related liver disorders.