bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Muscle Strength Training on Muscle Mass Gain and Hypertrophy in Older Adults With Osteoarthritis: A Systematic Review and Meta‐Analysis
Authors: Liao Chun‐De , Chen Hung‐Chou , Kuo Yu‐Chi , Tsauo Jau‐Yih , Huang Shih‐Wei , Liou Tsan‐Hon 
Published: October 2019

ObjectiveTo investigate the effect of muscle strength exercise training (MSET) on lean mass (LM) gain and muscle hypertrophy in older patients with lower extremity osteoarthritis (OA).MethodsA comprehensive search of online databases was performed on April 20, 2019. Randomized controlled trials (RCTs) that reported the effects of MSET on LM, muscle thickness, and cross‐sectional area (CSA) in older patients with OA were identified. A risk of bias assessment and meta‐analysis were performed for the included RCTs.ResultsWe included 19 RCTs with a median Physiotherapy Evidence Database score of 6 of 10 (range 3–7). In total, data from 1,195 patients (65% women, 85% with knee OA) with a mean age of 62.1 years (range 40–86 years) were analyzed. MSET resulted in significantly higher LM gain (standardized mean difference [SMD] 0.49 [95% confidence interval (95% CI) 0.28, 0.71], P < 0.00001) than did the nonexercise controls. Meta‐analysis results revealed significantly positive effects of MSET on muscle thickness (SMD 0.82 [95% CI 0.20, 1.43], P = 0.009) and CSA (SMD 0.80 [95% CI 0.25, 1.35], P = 0.004) compared with nonexercise controls. No significant effects in favor of MSET were observed for any muscle outcome compared with exercise controls. Five RCTs reported nonsevere adverse events in response to MSET, whereas no RCTs reported severe events.ConclusionMSET is effective in increasing LM and muscle size in older adults with OA. Clinicians should incorporate MSET into their management of patients at risk of low muscle mass to maximize health status, particularly for older individuals with OA.
Metal‐Free Three‐Component Selenopheno[2,3‐b]indole Formation through Double C−H Selenylation with Selenium Powder
Authors: Ni Penghui , Tan Jing , Zhao Wenqi , Huang Huawen , Deng Guo‐Jun 
Published: October 2019

AbstractA facile metal‐free entry to novel selenopheno[2,3‐b]indole motif is described. The three‐component assembly of indoles, aromatic ketones, and selenium powder is enabled by the IBr‐promoted highly selective double C–H selenylation/annulation. This protocol provides a novel access to a diverse variety of selenopheno[2,3‐b]indoles with good efficacy and broad functional group compatibility.magnified image
2‐Methyltetrahydrofuran (2‐MeTHF): A Green Solvent for Pd−NHC‐Catalyzed Amide and Ester Suzuki‐Miyaura Cross‐Coupling by N−C/O−C Cleavage
Authors: Lei Peng , Ling Yun , An Jie , Nolan Steven P. , Szostak Michal 
Published: October 2019

AbstractThe palladium‐NHC‐catalyzed (NHC=N‐heterocyclic carbene) Suzuki‐Miyaura cross‐coupling of amides and esters via highly chemoselective N−C(O) and O−C(O) cleavage with aryl boronic acids using green, sustainable and eco‐friendly 2‐methyltetrahydrofuran (2‐MeTHF) is reported. A variety of amides and aryl esters were coupled with aryl boronic acids in high to excellent yields. This method employs commercially‐available, air‐ and moisture‐stable Pd(II) −NHC precatalysts. Crucially, the use of 2‐MeTHF leads to the highest TON reported to date in amide N−C(O) bond cross‐coupling. This operationally‐simple protocol was utilized in the synthesis a bioactive ketone intermediate, emphasizing the potential of 2‐MeTHF as a green solvent in unconventional amide bond disconnection. Given the tremendous importance of amide bond cross‐coupling strategies and the drive to maintain full sustainability in cross‐coupling processes, we expect that the synthetic method will be of broad interest.magnified image
Mometasone absorption in cultured airway epithelium
Authors: Nguyen Tuong T. , Soma Paul S. , Mascenik Teresa , Lewis Catherine A. , Lee Rhianna E. , Thorp Brian D. , Zanation Adam M. , Ebert Charles S. , Senior Brent A. , Randell Scott H. , Ehrmann Brandie M. , Kimple Adam J. 
Published: October 2019

BackgroundTopical mometasone is frequently used as an intranasal spray, on drug‐eluting stents, and compounded by specialty pharmacies as a sinus rinse. A typical sinus rinse contains 1.2 mg of mometasone dissolved in 240 mL of buffered saline and is flushed through the sinonasal cavity. The mometasone irrigation rapidly flows to the contralateral sinonasal cavity or the nasopharynx with a contact time on the order of 5 to 10 seconds. However, no information is available on the absorption rate of topical mometasone on the sinonasal surface.MethodsTo determine the absorption characteristics of mometasone, we harvested nasal epithelium from 2 healthy donors and differentiated them into a mature ciliated epithelium on Millicell membranes. We applied mometasone to the apical surface for various time intervals and then rinsed off non‐absorbed mometasone with phosphate‐buffered saline. Millicell membranes with the adherent epithelial cells were then harvested and stored in guanidine hydrochloride for quantification using high‐performance liquid chromatography–mass spectrometry.ResultsFifty percent of the maximal absorption occurred after an average of 38 minutes after application, and maximal absorption occurred after an average of 114 minutes.ConclusionOur data provide an estimate for rates of absorption of mometasone applied to the sinonasal cavity and suggest that the absorption rates poorly match contact time during saline lavage.
Imaging Cell‐Matrix Adhesions and Collective Migration of Living Cells by Electrochemiluminescence Microscopy
Authors: Ding Hao , Guo Weiliang , Su Bin 
Published: October 2019

AbstractCell‐matrix adhesions play essential roles in a variety of biological processes. Herein, we report a label‐free method to map cell‐matrix adhesions of single living cells on an electrode surface by electrochemiluminescence (ECL). An indium tin oxide electrode modified with a silica nanochannel membrane was used as the substrate electrode, at which the ECL generation from freely diffusing luminophores provided a distinct visual contrast between adhesion sites and noncontacted domains, thus selectively revealing the former in a label‐free manner. With this methodology, we studied the spatial distribution, as well as dynamic variation, of cell‐matrix adhesions and the adhesion strength at the subcellular level. Cell‐matrix adhesions of an advancing cell sheet were finally imaged to study the movement of cells in collective migration. A statistical analysis suggests that cells on the far side of leading edge also have the propensity to migrate and do not act as just passive followers.
Finely Controlled Circularly Polarized Luminescence of a Mechano‐Responsive Supramolecular Polymer
Authors: Lee Seonae , Kim Ka Young , Jung Sung Ho , Lee Ji Ha , Yamada Mihoko , Sethy Ramarani , Kawai Tsuyoshi , Jung Jong Hwa 
Published: October 2019

AbstractFinely controlled circularly polarized luminescence (CPL) supramolecular polymerization based on a tetraphenylethene core with four l‐ or d‐alanine branch side chains (l‐1 and d‐1) in the solution state is presented, resulting from the tuning of mechanical stimulus. Weak, green emissions of l‐1 and d‐1 in tetrahydrofuran (THF) were converted into strong blue emissions by tuning the mechanical stimulus. The strong blue emissions were caused by an aggregation‐induced emission (AIE) effect during the formation of a supramolecular polymer. Lag time in the supramolecular polymerization was drastically reduced by the mechanical stimulus, which was indicative of the acceleration of the supramolecular polymerization. A significant enhancement of circular dichroism (CD) and CPL signals of l‐1 and d‐1 was observed by tuning the rotational speed of the mechanical stimulus, implying that the chiral supramolecular polymerization was accelerated by the mechanical stimulus.
Carbon‐Nanoplated CoS@TiO2 Nanofibrous Membrane: An Interface‐Engineered Heterojunction for High‐Efficiency Electrocatalytic Nitrogen Reduction
Authors: Liu Yi‐Tao , Chen Xingxing , Yu Jianyong , Ding Bin 
Published: October 2019

AbstractDeveloping noble‐metal‐free electrocatalysts is important to industrially viable ammonia synthesis through the nitrogen reduction reaction (NRR). However, the present transition‐metal electrocatalysts still suffer from low activity and Faradaic efficiency due to poor interfacial reaction kinetics. Herein, an interface‐engineered heterojunction, composed of CoS nanosheets anchored on a TiO2 nanofibrous membrane, is developed. The TiO2 nanofibrous membrane can uniformly confine the CoS nanosheets against agglomeration, and contribute substantially to the NRR performance. The intimate coupling between CoS and TiO2 enables easy charge transfer, resulting in fast reaction kinetics at the heterointerface. The conductivity and structural integrity of the heterojunction are further enhanced by carbon nanoplating. The resulting C@CoS@TiO2 electrocatalyst achieves a high ammonia yield (8.09×10−10 mol s−1 cm−2) and Faradaic efficiency (28.6 %), as well as long‐term durability.
Slow Dynamics of the Spin‐Crossover Process in an Apparent High‐Spin Mononuclear FeII Complex
Authors: Ye Yi Shan , Chen Xiu Qin , De Cai You , Fei Bin , Dechambenoit Pierre , Rouzières Mathieu , Mathonière Corine , Clérac Rodolphe , Bao Xin 
Published: October 2019

AbstractA mononuclear FeII complex that shows a high‐spin (S=2) paramagnetic behavior at all temperatures (with standard temperature‐scan rates, ≈1 K min−1) has, in fact, a low‐spin (S=0) ground state below 100 K. This low‐spin state is not easily accessible due to the extremely slow dynamics of the spin‐crossover process—a full relaxation from the metastable high‐spin state to the low‐spin ground state takes more than 5 h below 80 K. Bidirectional photo‐switching of the FeII state is achieved reproducibly by two selective irradiations (at 530–590 and 830–850 nm). The slow dynamics of the spin‐crossover and the strong structural cooperativity result in a remarkably wide 95‐K hysteresis loop induced by both temperature and selected light stimuli.
Catalytic Enantioselective Cyclopropenation of Internal Alkynes: Access to Difluoromethylated Three‐Membered Carbocycles
Authors: Zhang Zhi‐Qi , Zheng Meng‐Meng , Xue Xiao‐Song , Marek Ilan , Zhang Fa‐Guang , Ma Jun‐An 
Published: October 2019

AbstractHerein we described an efficient RhII‐catalyzed enantioselective cyclopropenation reaction of internal alkynes with a masked difluorodiazoethane reagent (PhSO2CF2CHN2, Ps‐DFA). This asymmetric transformation offers efficient access to a broad range of enantioenriched difluoromethylated cyclopropenes (40 examples, up to 99 % yield, 97 % ee). The synthetic utility of obtained strained carbocycles is demonstrated by subsequent stereodefined processes, including cross‐couplings, hydrogenation, Diels–Alder reaction, and Pauson–Khand reaction.
Investigation on the kinetics of cure reaction of acrylonitrile–butadiene rubber (NBR)/polyvinyl chloride (PVC)/graphene nanocomposite using various models
Authors: Barghamadi Mohammad , Ghoreishy Mir Hamid Reza , Karrabi Mohammad , Mohammadian‐Gezaz Somayyeh 
Published: October 2019

ABSTRACTThis research work is devoted to the study of the kinetics of the cure reaction of rubber nanocomposites based on the blend of acrylonitrile–butadiene rubber/poly(vinyl chloride) (NBR/PVC) (70/30) reinforced by graphene. Two series of nanocomposites were prepared using two grades of NBR [33 and 45% of acrylonitrile (ACN)] with a general‐purpose PVC. In each series, three graphene contents including 1, 2, and 3 phr were chosen in conjunction with neat polymer blend. The cure behaviors of the samples were quantified using rubber process analyzer and differential scanning calorimeter. The experimentally measured degree‐of‐cure and rate‐of‐cure were fitted to five different kinetic equations including Isayev, modified Isayev, Kamal and Ryan, autocatalytic, and model‐free approach. The parameters of these models were calculated. The accuracy of each model was checked by comparison of the predicted degree‐of‐cure and rate‐of‐cure with their corresponding experimental values. It is shown that by increasing the graphene content at constant ACN content, the activation energy is reduced while the rate‐of‐cure is increased. On the other hand, the activation energy is increased with increasing the ACN content at constant graphene content. Moreover, the results showed that Isayev model could not predict the curing behavior as accurate as of the other models due to the complex interaction between polymer with curing system and graphene. In addition, the analysis of the computed activation energy using the model‐free approached suggested that an advanced equation needs to be employed for the description of this parameter for rubber‐based nanocomposites. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48632.
Acaciain peptidase: The first South American pollen peptidase potentially involved in respiratory allergy
Authors: Barcia Cristina , Coelho Ana Sofia , Barberis Sonia , Veríssimo Paula 
Published: October 2019

AbstractAcacia caven (Mol.) Molina pollen causes pollinosis in South America. The aim of this work was to isolate, purify, and characterize the proteolytic enzymes of A. caven pollen, and study their influence on allergy. A series of chromatographic steps were applied to purify the proteolytic extract of A. caven pollen. The purified fraction was partially characterized, and then it was assayed on airway bioactive peptides (substance P, vasoactive intestinal peptide, and bradykinin), and peptide degradation was visualized by direct protein sequencing. The cellular detachment of an airway‐derived epithelial cell line (A‐549) was measured by methylene blue binding assay. The degradation of proteins from intercellular junctions (occludin, claudin, and E‐cadherin) was visualized by Western blot. A 75‐kDa peptidase, named acaciain peptidase, was purified and classified as a serine peptidase. Acaciain peptidase degraded bioactive peptides involved in the maintenance and recovery of the bronchomotor tone; it caused cellular detachment of A‐549 cell line, and degradation of intercellular junction proteins. Acaciain peptidase can alter the integrity of the epithelium barrier, causing cell permeability, increasing the allergic sensitization and exacerbating the overall bronchoconstrictive effect detected in asthmatic lungs. This novel serine peptidase constitutes a relevant therapeutic target in the treatment of allergic disorders.
Three‐Sodium Ion Activity of a Hollow Spherical Na3V2(PO4)2F3 Cathode: Demonstrating High Capacity and Stability
Authors: Mukherjee Ayan , Sharabani Tali , Perelshtein Ilana , Noked Malachi 
Published: October 2019

AbstractNa3V2(PO4)2F3 (NVPF) is a promising cathode material for sodium ion batteries, owing to its high voltage and promising cycling profile. Nevertheless, most previous reports demonstrated only approximately 100 mAh g−1 at limited operating voltage. Using a solvothermal synthesis route, we synthesized the NVPF cathode with a controlled architecture and spherical morphology. We used this electrode as the cathode for a sodium‐ion battery and managed to intercalate/deintercalate the third Na+ ion from the structure, demonstrating a high specific capacity (197 mAh g−1). Long‐term stability challenges of these electrodes under a wide potential regime are also presented here in.
Designer biocatalysts for direct incorporation of exogenous galactose into globotriose
Authors: Long Lingfeng , Azadi Parastoo , Chen Rachel 
Published: October 2019

AbstractGalactose is ubiquitous. The synthesis of galactose‐containing oligosaccharides using Leloir galactosyltransferase requires uridine diphosphate (UDP)‐galactose as the precursor. Of all UDP‐galactose synthesis pathways developed for in vitro synthesis, the salvage pathway represents the simplest route. In this study, for the first time, we designed and constructed an Escherichia coli strain to use salvage pathway for UDP‐galactose synthesis, demonstrating effective and direct incorporation of exogenous galactose into globotriose (Gb3). Successful establishment of salvage pathway enabled a complete delineation of carbon and energy source. Consequently, the designed biocatalyst was able to achieve high yield synthesis from galactose (0.95 moles of Gb3/moles galactose consumed) and a high product titer (2 g/L) in shaker flask within 24 hr. Elimination of limitation in acceptor sugar via homologous overexpression of LacY, the transporter for lactose, further improved the synthesis, raising Gb3 titer to 6 g/L in 24 hr and 7.5 g/L in 48 hr. The design principles successfully demonstrated in this study could be broadly applied for synthesis of other galactose‐containing oligosaccharides. This study also illustrates a valid strategy to overcome limitation in the transport of acceptor sugar. As lactose is one of the most important basal structures, the significant improvement in synthesis through its enhanced transport could be emulated in numerous other lactose‐based oligosaccharides.
Pharmacokinetic study of eight bioactive components following oral administration of Zhiqiao Gancao decoction and observation of its clinical efficacy
Authors: Shen Xiaofeng , Li Ling , Ma Qihan , Chen Hua , Wang Jiangping , Lv Lei , Li Yuwei 
Published: October 2019

AbstractZhiqiao Gancao (ZQGC) decoction is widely used in China due to its therapeutic effect on lumbar disc herniation (LDH). In this study, we compared the clinical therapeutic effects among oral ZQGC decoction treatment, bed rest, and oral anti‐inflammatory drug celecoxib treatment using visual analog scale, Oswestry Disability Index, and MacNab scores. The results showed that ZQGC decoction can significantly improve the symptoms of patients with LDH. A selective, sensitive, and rapid ultra‐performance liquid chromatography–tandem mass spectrometry method was developed and validated for the determination of eight bioactive components in rat plasma. The plasma samples were extracted by simple protein precipitation with methanol. The protonated analytes were quantitated simultaneously in positive and negative ion modes by multiple reaction monitoring with a mass spectrometer. The calibration curve of eight components in plasma showed good linearity (r > .996) and the extraction recovery was 81.19% ± 2.15% − 100.39 ± 3.36 (relative standard deviation: 1.21%–10.70%). The accuracy of all the lower limit of quantitation values was quantified within 80%–120%, and the precision was less than 15%. This validated method was successfully applied to the pharmacokinetics study in rat plasma after ZQGC decoction oral treatment. Our research can provide experimental basis for the rational clinical application of ZQGC decoction in the treatment of LDH.
Intranasal delivery of SDF‐1α‐preconditioned bone marrow mesenchymal cells improves remyelination in the cuprizone‐induced mouse model of multiple sclerosis
Authors: Beigi Boroujeni Fatemeh , Pasbakhsh Parichehr , Mortezaee Keywan , Pirhajati Vahid , Alizadeh Rafieh , Aryanpour Roya , Madadi Soheila , Ragerdi Kashani Iraj 
Published: October 2019

AbstractMultiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that leads to disability in middle‐aged individuals. High rates of apoptosis and inappropriate homing are limitations for the application of stem cells in cell therapy. Preconditioning of bone marrow mesenchymal stem cells (BMSCs) with stromal cell‐derived factor 1α (SDF‐1α), also called C‐X‐C motif chemokine 12 (CXCL12), is an approach for improving the functional features of the cells. The aim of this study was to investigate the therapeutic efficacy of intranasal delivery of SDF‐1α preconditioned BMSCs in the cuprizone‐induced chronically demyelinated mice model. BMSCs were isolated, cultured, and preconditioned with SDF‐1α. Then, intranasal delivery of the preconditioned cells was performed in the C57BL/6 mice receiving cuprizone for 12 weeks. Animals were killed at 30 days after cell delivery. SDF‐1α preconditioning increased C‐X‐C chemokine receptor type 4 (CXCR4) expression on the surface of BMSCs, improved survival of the cells, and decreased their apoptosis in vitro. SDF‐1α preconditioning also improved CXCL12 level within the brain, and enhanced spatial learning and memory (assessed by Morris water maze [MWM]), and myelination (assessed by Luxol fast blue [LFB] and transmission electron microscopy [TEM]). In addition, preconditioning of BMSCs with SDF‐1α reduced the protein expressions of glial fibrillary acidic protein and ionized calcium‐binding adapter molecule (Iba‐1) and increased the expressions of oligodendrocyte lineage transcription factor‐2 (Olig‐2) and adenomatous polyposis coli (APC), evaluated by immunofluorescence. The results showed the efficacy of intranasal delivery of SDF‐1α‐preconditioned BMSCs for improving remyelination in the cuprizone model of MS.
Sorafenib for relapsed FLT3‐ITD‐positive acute myeloid leukemia postallogeneic stem cell transplantation presenting as leukemia cutis
Authors: Brodie Rachel , Langabeer Stephen E. , Quinn John , McMenamin Máirín E. , Hayden Patrick J. 
Published: October 2019

AbstractRelapse of FLT3‐mutated acute myeloid leukemia (AML) following allogeneic stem cell transplantation is associated with poor survival. The clinical utility of sorafenib monotherapy in this setting is described in a patient presenting as leukemia cutis.
Synergistic Promotion of the Electrochemical Reduction of Nitrogen to Ammonia by Phosphorus and Potassium
Authors: Zhang Qikun , Liu Baoliang , Yu Liping , Bei Yiling , Tang Bo 
Published: October 2019

AbstractIn the process of electrochemical ammonia synthesis using an aqueous solution as the electrolyte, most protons will preferentially compete for electrons for hydrogen generation. Herein, the carbon cloth loaded with Nano‐Fe was used as the cathode, and a K3PO4 solution was used as the electrolyte. The electrochemical reduction of N2 to NH3 was investigated. It was found that the K3PO4 electrolyte had an obvious promotion effect on the ammonia synthesis efficiency compared with other electrolytes. It was confirmed that phosphorus and potassium had a synergistic effect on the ammonia synthesis efficiency. K+ can effectively prevent H+ from adsorbing to the active site of a catalyst surface, thus inhibiting the formation of hydrogen. The solubility of the phosphate solution for N2 is better than that of other aqueous electrolyte solutions, thus effectively improving the ammonia production efficiency. The highest ammonia yield was 79.0±5×10−11 mol ⋅ s−1 ⋅ cm−2, and the faraday efficiency reached 16.68 %. These results provide an effective way to improve the conversion yield of electrochemical ammonia synthesis in water systems.
Three‐Dimensional Hierarchical Porous Carbon/Graphitic Carbon Nitride Composites for Efficient Photocatalytic Hydrogen Production
Authors: Wang Chenlu , Liu Guigao , Song Kai , Wang Xinqian , Wang Hang , Zhao Naiqin , He Fang 
Published: October 2019

AbstractDeveloping low‐cost, wide‐source, and nontoxicity photocatalysts is highly desirable for application in efficient solar energy conversion. In this work, a series of nanosheet‐assembled three‐dimensional (3D) hierarchical porous carbon/graphitic carbon nitride (3D C/g‐C3N4) composites have been successfully synthesized as efficient photocatalysts for hydrogen production. The optimal 3D C/g‐C3N4 shows the largest H2 evolution rate of 1610 μmol h−1 g−1, which is nearly seven times that of bulk g‐C3N4. Such remarkably improved photocatalytic performance is mainly attributed to that: i) the 3D carbon effectively prevents nanosheets from agglomeration as well as serves as high speed channels for electron transport; ii) the interconnected porous network is favorable for the multiple reflections and utilization of light; and iii) the interfacial interaction between g‐C3N4 and 3D carbon is beneficial to the charge separation and transfer.