bluuebunny/crossref_metadata_2025_split huggingface dataset:
New observations in Central Italy of groundwater responses to the worldwide seismicity
Authors: Barberio Marino Domenico , Gori Francesca , Barbieri Maurizio , Billi Andrea , Caracausi Antonio , De Luca Gaetano , Franchini Stefania , Petitta Marco , Doglioni Carlo 
Published: October 2020

AbstractChemical and physical responses of groundwater to seismicity have been documented for thousands of years. Among the waves produced by earthquakes, Rayleigh waves can spread to great distances and produce hydrogeological perturbations in response to their passage. In this work, the groundwater level, which was continuously recorded in a monitoring well in Central Italy between July 2014 and December 2019, exhibited evident responses to dynamic crustal stress. In detail, 18 sharp variations of the groundwater level due to worldwide Mw ≥ 6.5 earthquakes were observed. Apart from earthquakes that occurred in Papua New Guinea and those with a hypocentral depth > 150 km, all far away Mw ≥ 7.6 earthquakes produced impulsive oscillations of groundwater. As the earthquake magnitude decreased, only some earthquakes with 6.5 ≤ Mw < 7.6 caused groundwater level perturbations, depending on the data acquisition frequency and epicentral distance from the monitoring well. A clear correlation between earthquake distance and magnitude in hydrogeological responses was found. Our results shed light on the hydrosensitivity of the study site and on the characteristics of fractured aquifer systems. Detecting the water table variations induced by distant earthquakes is another step towards a correct identification of (preseismic) hydrogeological changes due to near-field seismicity.
Novel strategy of remote magnetic navigation-guided ablation for ventricular arrhythmias from right ventricle outflow tract
Authors: Xie Yun , Liu Ao , Jin Qi , Zhang Ning , Jia Kangni , Lin Changjian , Ling Tianyou , Chen Kang , Pan Wenqi , Wu Liqun 
Published: October 2020

AbstractThe optimized strategy to further increase the success rate of ablation for ventricular arrhythmias (VAs) from the right ventricular outflow tract (RVOT) is challenging. Recent studies have shown that the pulmonary sinus cusp (PSC) region may be the origin of certain RVOT VAs. We evaluated the efficacy of preferential ablation below the pulmonary valve (PV) and alternated radiofrequency delivery in the PSC using remote magnetic navigation (RMN). Sixty-five (65) consecutive patients experiencing VAs with RVOT-like appearance were included in this study. Mapping and ablation were preferentially performed below the PV. Ablation in the PSC would only be attempted when intensified ablation below the PV could not eliminate VAs. Finally, if ablation in the RVOT region failed, the aortic sinus cusp (ASC) would be mapped. Sixty-one (61) of 65 (93.8%) patients achieved procedural success. Except 7 cases of which the VAs were ablated in the ASC, the rest 54 VAs were thought to be originate from the RVOT region. Fifty (50) of 54 VAs were successfully ablated below the PV, and in the presence of a local special signal in the bipolar electrogram a more aggressive ablation was required. Subsequent ablation in the PSC with assistance of the RMN system achieved success in the remaining 4 patients. No complications occurred in this study. Our strategy of using RMN-guided ablation below the PV for VAs of RVOT origin was proved to be effective. PSC mapping and ablation using a magnetic catheter may provide the optimal strategy for treating these types of arrhythmias.
Effects of energy metabolism on the mechanical properties of breast cancer cells
Authors: Yubero Marina. L. , Kosaka Priscila M. , San Paulo Álvaro , Malumbres Marcos , Calleja Montserrat , Tamayo Javier 
Published: October 2020

AbstractTumorigenesis induces actin cortex remodeling, which makes cancerous cells softer. Cell deformability is largely determined by myosin-driven cortical tension and actin fiber architecture at the cell cortex. However, it is still unclear what the weight of each contribution is, and how these contributions change during cancer development. Moreover, little attention has been paid to the effect of energy metabolism on this phenomenon and its reprogramming in cancer. Here, we perform precise two-dimensional mechanical phenotyping based on power-law rheology to unveil the contributions of myosin II, actin fiber architecture and energy metabolism to the deformability of healthy (MCF-10A), noninvasive cancerous (MCF-7), and metastatic (MDA-MB-231) human breast epithelial cells. Contrary to the perception that the actin cortex is a passive structure that provides mechanical resistance to the cell, we find that this is only true when the actin cortex is activated by metabolic processes. The results show marked differences in the nature of the active processes that build up cell stiffness, namely that healthy cells use ATP-driven actin polymerization whereas metastatic cells use myosin II activity. Noninvasive cancerous cells exhibit an anomalous behavior, as their stiffness is not as affected by the lack of nutrients and ATP, suggesting that energy metabolism reprogramming is used to sustain active processes at the actin cortex.
Micro-RNA 122 and micro-RNA 96 affected human osteosarcoma biological behavior and associated with prognosis of patients with osteosarcoma
Authors: Liu Bin , Yao Shuqiang , Zhou Jiping 
Published: October 2020

AbstractOsteosarcoma (OS) is the most common bone malignancy in both children and adolescents. In the present study, we aimed to explore the association of miRNA-122 and miRNA-96 expression with the clinical characteristics and prognosis of patients with osteosarcoma. The expression of miRNA-122 and miRNA-96 in human osteosarcoma cell lines and tissues were detected in the present study. Reverse transcriptase-PCR (RT-PCR) was used to determine the expression levels of miRNA-122 and miRNA-96 in 68 human OS samples. We found that MiRNA-122 and miRNA-96 were widely up-regulated in osteosarcoma, gastric cancer and pancreatic cancer. In HOS, Saos-2 and U2OS osteosarcoma cells, miRNA-122 and miRNA-96 were up-regulated significantly, while down-regulated in MG-63 cells. After further investigation, we found that miRNA-122 and miRNA-96 concentrations were significantly higher in the tumor tissues than those in the normal tissues (P&lt;0.01). Moreover, the cell proliferation of LV-miRNA-122-RNAi and LV-miRNA-96-RNAi transfected SaOS2 was significantly decreased compared with the LV- miRNA-122-RNAi-CN and LV- miRNA-96-RNAi group. After adjusting for competing risk factors, we found combined high miRNA-122 and miRNA-96 expression was identified as independent predictor of overall survival.
The Relation of Articulatory and Vocal Auditory–Motor Control in Typical Speakers
Authors: Lester-Smith Rosemary A. , Daliri Ayoub , Enos Nicole , Abur Defne , Lupiani Ashling A. , Letcher Sophia , Stepp Cara E. 
Published: October 2020

Purpose

The purpose of this study was to explore the relationship between feedback and feedforward control of articulation and voice by measuring reflexive and adaptive responses to first formant (
F
1
) and fundamental frequency (
f
o
) perturbations. In addition, perception of
F
1
and
f
o
perturbation was estimated using passive (listening) and active (speaking) just noticeable difference paradigms to assess the relation of auditory acuity to reflexive and adaptive responses.

Method

Twenty healthy women produced single words and sustained vowels while the
F
1
or
f
o
of their auditory feedback was suddenly and unpredictably perturbed to assess reflexive responses or gradually and predictably perturbed to assess adaptive responses.

Results

Typical speakers' reflexive responses to sudden perturbation of
F
1
were related to their adaptive responses to gradual perturbation of
F
1
. Specifically, speakers with larger reflexive responses to sudden perturbation of
F
1
had larger adaptive responses to gradual perturbation of
F
1
. Furthermore, their reflexive responses to sudden perturbation of
F
1
were associated with their passive auditory acuity to
F
1
such that speakers with better auditory acuity to
F
1
produced larger reflexive responses to sudden perturbations of
F
1
. Typical speakers' adaptive responses to gradual perturbation of
F
1
were not associated with their auditory acuity to
F
1
. Speakers' reflexive and adaptive responses to perturbation of
f
o
were not related, nor were their responses related to either measure of auditory acuity to
f
o
.

Conclusion
These findings indicate that there may be disparate feedback and feedforward control mechanisms for articulatory and vocal error correction based on auditory feedback.
Diagnostic génétique et physiologique de la face sur téléradiographie de profil par forme mathématisée : un quadrilatère
Authors: Benoît Roland 
Published: October 2020

Dans cet article, nous proposons une analyse sagittale, mathématisée de la face et du crâne, selon un procédé géométrique : un quadrilatère.
Ce quadrilatère présente un principe d’économie naturelle dans sa construction (la description de l’analyse a été décrite dans un article publié en 2018, dans la Revue d’ODF[3]).
Il permet d’établir pour chaque patient un diagnostic et de proposer des objectifs de coordination pour les structures squelettiques, musculaires et dentaires, en vue d’obtenir une meilleure efficacité des fonctions de mastication, de respiration et d’expressivité.
Cette analyse est appliquée à trois types de typologies différentes…
Cette analyse basée sur des données génétiques permet de coordonner structures et fonctions.
Kortisolkonzentration bei Deutsch-Holstein-Kühen vor, während und nach der Klauenbehandlung im Durchtreibestand – Eignung verschiedener Matrizes
Authors: Heinrich Maria , Müller Hendrik , Fieseler Helena , Steiner Adrian , Gottschalk Jutta , Einspanier Almuth , Spilke Joachim , Mielenz Norbert , Palme Rupert , Baumgartner Walter , Möbius Gerd , Starke Alexander 
Published: October 2020

ZusammenfassungZiel Überprüfung, ob sich die Änderung der Kortisolkonzentration im Blut (KoB) von Milchkühen während eines akuten Stressreizes durch die Kortisolkonzentration im Speichel (KoS), in der Tränenflüssigkeit (KoTr) und in der Milch (KoM) und die Kortisolmetabolitenkonzentration im Kot (KoK) nachvollziehen lässt.Material und Methoden Bei 10 gesunden Deutsch-Holstein-Kühen diente eine simulierte Klauenbehandlung (sKB) im Durchtreibestand als Modell für eine akute Stresssituation. KoB, KoS, KoTr, KoM sowie KoK wurden einmal täglich über 10 Tage gemessen. Bei der an Tag 4 durchgeführten sKB wurden die KoB und KoTr (Minute 0, 15, 25, 30, 40, 50, 60, 80) und die KoK (Minute 480, 540, 600, 660) bestimmt.Ergebnisse Während der sKB stiegen die KoB und KoTr (Maximum zu Minute 60) und fielen anschließend ab. Nach der sKB kam es zu einem Anstieg der KoK (Maximum zu Minute 660). Während der sKB korrelierten KoB und KoTr sowie KoK und KoTr signifikant und KoK und KoB tendenziell. Im gesamten Verlauf der sKB (Area under the Curve [AUC], Minute 0–80) zeigten KoB und KoTr eine signifikante Korrelation (p = 0,04). Die KoB fiel von Tag 1 zu Tag 4 signifikant ab (p < 0,01). An Tag 5 waren KoB (p = 0,03) und KoK (p < 0,01) signifikant höher. Der Verlauf der KoS und KoTr (Tag 1–10) spiegelte den KoB-Verlauf gut wider. Der Verlauf der KoK wies Parallelen, der von KoM einige Unterschiede zum Verlauf der KoB auf. Deutlich positive Korrelationen ergaben sich für den Zeitraum Tag 1–10 im Vergleich von KoB und KoS (p = 0,002) sowie von KoB und KoTr (p = 0,002).Schlussfolgerungen und klinische Relevanz Die Gewinnung von Tränenflüssigkeit und Speichel stellt bei der Bestimmung der Kortisolkonzentration eine Alternative zur invasiven Blutentnahme dar. Ein ruhiger Umgang mit den Kühen führt zu einer geringeren Stressreaktion und kann somit das Tierwohl verbessern.
Stoma Closure Improves Head Circumference Growth in Very Preterm Infants after Necrotizing Enterocolitis
Authors: Honoré Karina Dyrvig , Johansen Malene Nygaard , Rasmussen Lars , Zachariassen Gitte 
Published: October 2020

Abstract
Introduction Very preterm infants (VPIs) surgically treated for necrotizing enterocolitis (NEC) are at risk of growth retardation. The aim of this study was to demonstrate and compare growth during the first 6 years of life in VPIs with stoma after NEC surgery with VPIs without NEC surgery.
Materials and Methods We included all VPIs surgically treated due to NEC at the Odense University Hospital from August 1, 2004, to July 31, 2008. Outcome on growth was compared with a group of VPIs without NEC. The VPIs with NEC were identified searching the local database using the International Classification of Diseases, 10th Revision diagnosis of NEC (DP77.9). Data on growth were collected from medical files and if not present, the parents reported the data.
Results Nineteen VPIs, surgically treated due to NEC, survived to 6 years of age. Median gestational age was 283/7 weeks (245/7–313/7). Median age at NEC surgery and stoma formation was 2.3 weeks (0.1–6.3) and median age at stoma closure was 2.5 months corrected age (CA) (postmenstrual age 36 weeks to CA 6.7 months). Compared with the non-NEC group, VPIs with NEC and stoma demonstrated poor growth, especially in head circumference (HC) with no increase in growth velocity before the time of stoma closure between 2.5- and 3-month CAs.
Conclusion Our findings demonstrate poor growth in VPIs after NEC surgery and improved HC growth after stoma closure.
Frequently Asked Questions about Thrombosis during COVID-19 Pandemic
Authors: Golemi Lolita , Hanson Peter , Tafur Alfonso 
Published: October 2020

AbstractThe coronavirus disease 2019 (COVID-19) pandemic and the “shelter-in-place” orders have placed a significant strain on patients and providers. We believe that patient education is crucial during these times, so together with their health care providers, the patients can make the best decisions in regard to their health. Anchored on a patient-perspective, we summarize frequently asked questions illustrating a growing thrombosis concern.
Pathology and Pathogenesis of Adenomyosis
Authors: Antero Maria Facadio , Ayhan Ayse , Segars James , Shih Ie-Ming 
Published: October 2020

AbstractAdenomyosis represents a unique pathophysiological condition in which normal-appearing endometrial mucosa resides within myometrium and is thus protected from menstrual shedding. The resulting ectopic presence of endometrial tissue composed of glands and stroma is thought to affect normal contractile function and peristalsis of uterine smooth muscle, causing menometrorrhagia, infertility, and adverse obstetric outcomes. Since the first description of adenomyosis more than 150 years ago, pathologists have studied this lesion by examining tissue specimens, and have proposed multiple explanations to account for its pathogenesis. However, as compared with endometriosis, progress of adenomyosis research has been, at best, incremental mainly due to the lack of standardized protocols in sampling tissue and a lack of consensus diagnostic criteria in pathology practice. Despite these limitations, recent advances in revealing the detailed anatomy and biology of eutopic endometrium offer an unprecedented opportunity to study this common but relatively understudied disorder. Here, we briefly summarize the pathological aspects of adenomyosis from an historical background, and discuss conventional morphology and recent tissue-based molecular studies with a special emphasis on elucidating its tissue of origin from a pathologist's perspective. We also discuss unmet needs in pathology studies that would be important for advancing adenomyosis research.
Global diversity of microbial communities in marine sediment
Authors: Hoshino Tatsuhiko , Doi Hideyuki , Uramoto Go-Ichiro , Wörmer Lars , Adhikari Rishi R. , Xiao Nan , Morono Yuki , D’Hondt Steven , Hinrichs Kai-Uwe , Inagaki Fumio 
Published: October 2020

SignificanceMarine sediment covers 70% of Earth’s surface and harbors as much biomass as seawater. However, the global taxonomic diversity of marine sedimentary communities, and the spatial distribution of that diversity remain unclear. We investigated microbial composition from 40 globally distributed sampling locations, spanning sediment depths of 0.1 to 678 m. Statistical analysis reveals that oxygen presence or absence and organic carbon concentration are key environmental factors for defining taxonomic composition and diversity of marine sedimentary communities. Global marine sedimentary taxonomic richness predicted by species–area relationship models is 7.85 × 103to 6.10 × 105for Archaea and 3.28 × 104to 2.46 × 106for Bacteria as amplicon sequence variants, which is comparable to the richness in seawater and that in topsoil.
Revealing mechanisms of mating plug function under sexual selection
Authors: Stockley Paula , Franco Catarina , Claydon Amy J. , Davidson Amanda , Hammond Dean E. , Brownridge Philip J. , Hurst Jane L. , Beynon Robert J. 
Published: October 2020

SignificancePromiscuous mating by females leads to competition between males for fertilization success. When fertilization is internal, this means that rival males’ sperm must compete within the female reproductive tract to reach the eggs. Males of diverse species deposit a mating plug during copulation, which is hypothesized to assist in the race for fertilization following multiple mating. Here, we tested this by using stable isotope labeling to discriminate the ejaculates of competing male voles in direct competition. This revealed that the mating plug simultaneously inhibits the sperm of rival males while promoting transport of a male’s own sperm, both of which are beneficial in the competition for fertilizations.
Changing nutrient cycling in Lake Baikal, the world’s oldest lake
Authors: Swann George E. A. , Panizzo Virginia N. , Piccolroaz Sebastiano , Pashley Vanessa , Horstwood Matthew S. A. , Roberts Sarah , Vologina Elena , Piotrowska Natalia , Sturm Michael , Zhdanov Andre , Granin Nikolay , Norman Charlotte , McGowan Suzanne , Mackay Anson W. 
Published: October 2020

Significance
Lake Baikal (Siberia) is the world’s oldest and deepest lake and a UNESCO World Heritage Site. Containing an exceptionally high level of biodiversity and endemism, in addition to a fifth of global freshwater not stored in ice sheets, the lake has been cited by UNESCO as the “most outstanding example of a freshwater ecosystem.” Using geochemical and climate data, we demonstrate that rates of nutrient supply to the lake’s photic zone have risen to unprecedented levels in the last 2,000 y through the 20th and 21st centuries. Linked to increases in wind speed enhancing deep ventilation, we show that these changes are capable of altering lake primary production and community dynamics, including the balance between endemic and cosmopolitan species.
Frequency doubling in a pendulum
Authors: Reinhold S , Ziese M 
Published: October 2020

Abstract
A smartphone is used as a pendulum bob to simultaneously measure the angular velocity and the acceleration of a pendulum. The data show a frequency doubling in the radial acceleration component compared with the angular velocity and the azimuthal acceleration component. This is mainly due to the centrifugal force and is an illustration of frequency doubling in a simple mechanical system. This experiment might be used in first year university physics courses to teach frequency analysis and frequency doubling in a home laboratory.
Adaptive spectral decompositions for inverse medium problems
Authors: Baffet Daniel H , Grote Marcus J , Tang Jet Hoe 
Published: October 2020

Abstract
Inverse medium problems involve the reconstruction of a spatially varying unknown medium from available observations by exploring a restricted search space of possible solutions. Standard grid-based representations are very general but all too often computationally prohibitive due to the high dimension of the search space. Adaptive spectral decompositions instead expand the unknown medium in a basis of eigenfunctions of a judicious elliptic operator, which depends itself on the medium. Here the AS decomposition is combined with a standard inexact Newton-type method for the solution of time-harmonic scattering problems governed by the Helmholtz equation. By repeatedly adapting both the eigenfunction basis and its dimension, the resulting adaptive spectral inversion (ASI) method substantially reduces the dimension of the search space during the nonlinear optimization. Rigorous estimates of the AS decomposition are proved for a general piecewise constant medium. Numerical results illustrate the accuracy and efficiency of the ASI method for time-harmonic inverse scattering problems, including a salt dome model from geophysics.
Fabrication and characterization of micro electromagnetic linear actuators
Authors: Zhi Chao , Qu Mingshan , Wang Yue , Li Yanjun , Xie Jin , Feng Wei , Tang Bin 
Published: October 2020

Abstract
This paper on the reports design, fabrication and position monitoring of a micro electromagnetic linear actuator. The actuator consists of stator, slider, guide, sensors and affiliated jigs. Actuation is achieved through ampere force between two phase micro-coils (copper) on the stator and permanent magnets (thick NdFeB film) on the slider. During the slider’s movement in the guide slot, tunnelling magneto-resistance (TMR) sensors are utilized to sense the magnetic field to realize position monitoring. TMR is chosen because it owns advantages of small size, large sensitivity and easy integration with micro devices. Purpose of this research is to report the micro fabrication of thick magnet films and testify the possibility of using TMR as position monitoring sensors. Actuators are fabricated by micro-electro-mechanical system process (stator and guide) and precise machining (slider and jigs). Surface magnetic field generated by the slider, driving characteristics of the actuator as well as the position monitoring capabilities of TMR elements are simulated and experimented, respectively. The slider attains 60 mm s−1 speed by sinusoidal input signal at 300 Hz frequency and 0.2 A current magnitude. Actuation bandwidth is between 300 Hz and 500 Hz at open loop condition. The maximum position monitoring error in present work is 2.2% with 101 μm value for 4.5 mm stroke.
Numerical simulation of an atmospheric pressure plasma jet with coaxial shielding gas
Authors: Lin Peng , Zhang Jiao , Nguyen Tam , Donnelly Vincent M , Economou Demetre J 
Published: October 2020

Abstract
A two-dimensional (r, z) numerical simulation of the discharge characteristics of an atmospheric pressure plasma jet (APPJ), with coaxial shielding gas, was performed. The helium working gas flowed in a central capillary tube, engulfing a needle electrode powered by 13.7 MHz radio frequency sinusoidal voltage. The N2 shielding gas flowed in the annular space of a coaxial tube. These gases emerged, in laminar flow, in a 78%N2-21%O2-1%Ar dry air ambient. The characteristics of the APPJ with shielding gas were compared to those of the APPJ without shielding gas. The nitrogen shielding gas hindered the diffusion of oxygen and argon from the ambient air into the helium jet. With the shielding gas present, more nitrogen penetrated into the helium core, causing a shorter plasma ‘plume’. The flow rates of the working and shielding gas, critically affected the gas temperature, and in turn the discharge characteristics. For a He flow of 2 standard liters per minute (slm), switching on the nitrogen shielding gas flow (at 4.5 slm) reduced the on-axis O2 and Ar mole fractions from

3.9
×

10

−
4

to

6.8
×

10

−
5

and from

1.9
×

10

−
5

to

3.3
×

10

−
6

, respectively, at an axial distance of 3 mm downstream of the nozzle. The radial profiles of the mole fractions of the ambient gases were monotonically and strongly decreasing towards the system axis, for short axial distances from the nozzle (∼1 mm), but became progressively flatter at longer distances from the nozzle (3 mm and 5 mm). Simulation predictions captured the salient features of experimental data of ambient species mole fractions in the plasma jet, and the 706 nm optical emission intensity profiles of the He 33S excited state.