bluuebunny/crossref_metadata_2025_split huggingface dataset:
BİR EĞİTİM VE ARAŞTIRMA HASTANESİ'NDE 65 YAŞ VE ÜZERİ ALT GASTROİNTESTİNAL SİSTEM ENDOSKOPİK BULGULARIN DEĞERLENDİRİLMESİ
Authors: ÜSTÜNDAĞ ÖCAL Nursel , YAMAN Sevda , YANIK Serdar 
Published: November 2019

ÖZET

Amaç:
Bu çalışmada amaç, bir eğitim araştırma
Hastanesi’nde 65 yaş ve üzeri alt gastrointestinal sistem endoskopik
bulgularının retrospektif olarak incelenmesi amaçlanmıştır.

Gereç
ve Yöntem: Kesitsel
tanımlayıcı nitelikte olan çalışma, İç Anadolu Bölgesinde Bir Üniversitenin Tıp Fakültesi Gastroenteroloji,
İç Hastalıkları ve Genel Cerrahi bilim dallarına 01.01.2015 ile 02.05.2018
tarihleri arasında başvuran hastalar üzerinde yapıldı. Alt gastrointestinal
sistem endoskopisi uygulanan hastaların tamamının (155 hasta) patoloji sonuçları retrospektif olarak
incelendi.

Bulgular: Çalışmada
toplam 155 olgu değerlendirildi. Olguların 56’sını (%36.53) kadınlar, 99’unu
(%63.87) erkekler oluşturdu. Hastaların biyopsi sonuçları içerisinde en sık 82
(%52.90) olguda adenomlar , en düşük 9 (%5.80) olguda kolit tespit edildi.

Sonuçlar: Tüm dünyada ve ülkemizde yaşlı nüfus
popülasyonu artmaktadır. Artan yaşlı popülasyonda ileri yaşla birlikte
kolorektal kanser görülme sıklığıda artmaktadır. Yaşlı popülasyonda kolorektal
kanser taramalarının düzenli bir şekilde yapılması ve bireylere bu konuda
farkındalığı arttırıcı çalışmaların yapılması yararlı olacaktır.

Anahtar
Kelimeler: Yaşlı;
Kolorektal Kanserler; kolonoskopi

EVALUATION OF LOWER GASTROINTESTINAL SYSTEM ENDOSCOPIC FINDINGS AGED 65 YEARS AND OVER IN A TRAINING AND RESEARCH HOSPITAL

ABSTRACT

Objective: The purpose of this study was to retrospectively investigate the endoscopic findings of the gastrointestinal system at 65 years of age and above at an educational research hospital.Methods: The study, which is a cross-sectional descriptive study, was performed on the patients who applied to a University in Central Anatolia Region Faculty of Medicine between the dates of 01.01.2015 and 02.05.2018 for the branches of Gastroenterology, Internal Medicine and General Surgery. Pathologic results of all patients undergoing lower gastrointestinal endoscopy (155 patients) were retrospectively reviewed.Results: A total of 155 cases were evaluated in the study. Of the cases, 56 (36.53%) were women and 99 (63.87%) were men. Among the biopsy results of the patients, 82 (52.90%) were the most common adenomas and the lowest 9 (5.80%) were colitis.Conclusion: The population of the elderly population is increasing all over the world and in our country. In the aging population, the incidence of colorectal cancer increases with older age. It would be beneficial to carry out regular screening of colorectal cancer in the elderly population and to make individuals aware of this issue.

Keywords: Elderly; Colorectal
Cancer; Colonoscopy
Improvement of the Upstream Project Valuation in Consideration of Abandonment Expenditure ABEX Uncertainties
Authors: Abu Bakar Azureen Alya , M Jais Mashitah 
Published: November 2019

Abstract
This study intends to propose parameter adjustment for economic evaluation in considering abandonment expenditures (ABEX) during front end loading (FEL) of discovered petroleum resources. In maturing a petroleum field development, abandonment and decommissioning of wells and facilities requires consideration during FEL. FEL, long adopted by prominent E&P players worldwide is used to support capital investment decision-making where value i.e. expected monetary wealth is measured and evaluated by Discounted Cash Flow (DCF) analysis. However, the DCF approach is outdated and flawed where it does not capture fluctuation well. This study reviews ABEX of sub-commercial contingent resources or shelved projects and economic evaluation method used in the author’s organization and their parameters, identifying relevant and applicable adjustments that could be made associated to ABEX. Combining the revised ABEX with a modified economic model, a proposed set of categorical adjustments to is produced. The results show that the ABEX of the previously sub-commercial projects yield a more competitive number with revised semi-detailed estimates and different escalation and inflation approaches. Additionally, a standardized assumption for abandonment year before cessation of production is recommended to provide a more realistic evaluation of when ABEX is actually required to incur. These, in turn, improves the Net Present Value (NPV) of the projects tested as well as their viability and rank towards being sanctioned for development.
Potential of Offshore Structure as Artificial Reefs in Shallow Tropical Water
Authors: Zawawi Noor Amila , Liew M.S.. S. , Shawn Lim Eu , Alaloul Wesam Salah , Toloue Iraj , Mohd Mohd Hairil , Rahman Mohd Asamudin , Nazri Muhammad Nadzrin , Tan Chun-Hong , Mohamad Yuzwan , Lim Chuin-Siew , Mustapa Baharim , Shaari Hasrizal , Hii Yii-Siang , Akbar Ali M Nasahie , Thiyauddin M Izzat , Abdul Karim Marcella 
Published: November 2019

Abstract
Reefing of Oil and Gas structure has become as one of the emerging options for decommissioning of an O&G Structure offshore and requires expert input beyond engineering such as biomarine and environmental sciences. This paper will present the interdisciplinary collaborative effort by industries with academia in Malaysia in developing a reef viability index as the first high level screening to assess the suitability of decommissioning using the reefing option in the region. The results of the reef viability index formulation to identify an offshore area that potential to be used for Rigs-to-Reefs (RTR) program in the South China Sea. The integration of data collection, numerical modelling and Geographic Information System (GIS) aims to review the relationship of coral reefs spawning ground, diversity and planula larvae in the colonization process which to produce a reefing area map. Coral connectivity and spawning behaviour were investigated to reveal the potential source of coral seedling as well as the number of coral larvae based on different taxa released during the spawning seasons. A spatial reef viability index was developed based on seven parameters, i.e. coral larval density, pelagic larval duration, sea currents, temperature, chlorophyll-a, depth, and substrate availability. Hydrodynamic model was developed to emulate the pattern of larval scattering. Based on the simulation and rankings, there were 95 (21%) sites that are most likely for in-situ reefing while the remaining 358 (79%) sites were probably suitable for ex-situ reefing or decommissioning. Validation of the viability index was done using Remotely Operated Vehicle (ROV) media footage assessment.
Decommissioning Cost Reduction by Effective Planning of Decommissioning Projects Using Facility Removal Date as a Reference Point
Authors: Tung Aaron , Otto Claus 
Published: November 2019

Abstract
This paper reviews the existing planning process for decommissioning projects on the United Kingdom Continental Shelf (UKCS) and explores an alternative approach of planning decommissioning activities with reference to ‘Facility Removal Date’ rather than with reference to ‘Cessation of Production Date’.
This alternative approach aims to enable a more effective planning of decommissioning activities in a high oil price and limited supply chain capacity environment to achieve cost reduction by:
Improve Supply Chain Impact on Decommissioning Projects Provide Better Opportunities for Aggregation of Scope Promote Development of the Supply Chain
This alternative planning approach offers a way for project engineers to plan decommissioning activities by using a new point of reference which offers a clearer distinction that separates well plugging and abandonment and facility’s removal operations in decommissioning projects. This alternative approach involves putting ‘Facility Removal Date’ as the main starting point of reference when planning decommissioning activities. This is an emergent insight from research investigating development of stakeholder-oriented critical paths, which was carried out using a mixed-method methodology incorporating
Case Studies on Decommissioning Projects in the UKCS Semi-structured Interviews with Industry Representatives in the UKCS
This alternative approach demonstrates the importance of the supply chain as a stakeholder in the UKCS decommissioning landscape. This paper will discuss the anticipated increase in demand and decommissioning activities in the UKCS and how it will correspond to an increasing supply chain influence and subsequent impacts on decommissioning projects. It will also show the effect of changing well plugging and abandonment strategies over the years on the change in significance of the ‘Cessation of Production Date’ and ‘Facility Removal Date’.
This paper will discuss the emergent insights discovered when using ‘Facility Removal Date’ during the development of the critical paths. It will then further discuss how using ‘facility removal date’ in decommissioning planning can enable a more effective scheduling of activities, reduce uncertainty for the supply chain, and promote aggregation of scope, leading to cost reduction in decommissioning. The discussions will be further supported by qualitative data obtained from semi-structured interviews used for the development of the stakeholder-oriented critical paths.
Bismuth Abandonment Plugs: The Possibilities are Endless
Authors: Fulks Jeff , Carragher Paul , Prapoo Hema 
Published: November 2019

Abstract
Well abandonment is often not thought of as a crucial part of a well’s life. As such, traditional methods of abandoning a well utilizing cement and bridge plugs are still common practice among most operators throughout the world. Although resins have been utilized by some as an alternative, there have not been any major new developments in well abandonment materials for nearly 100 years. Although each of these materials have their benefits, there are also limitations to their sealing capabilities. Bridge plugs lack a high expansion ratio required in some wells and rely on elastomers to seal, limiting their ability to seal in damaged tubing or open hole environments. Due to the unique properties of bismuth, plugs can be achieved with an expansion ratio of 3:1 and take the shape of the environment they are being set in. Cement is porous and lacks the ability to block gasses from migrating through it while bismuth has no porosity, making it an ideal material for stoping gas migration. Resins must be squeezed into an area and can take days to fully cure before a seal is created as opposed to bismuth which flows in a a well via gravity and solidifies to create a seal in a few hours. This paper will demonstrate a new way to create gas tight seals during well abandonment, overcoming the limitations of traditional methods and reducing the operator’s liability and potential environmental impact after decommissioning has been completed.
Identification of Significant Climatic Risk Factors and Machine Learning Models in Dengue Outbreak Prediction
Authors: Nejad Felestin Yavari , Varathan Kasturi Dewi 
Published: November 2019

Abstract
Background:
Dengue fever is a widespread viral disease and one of the world’s major pandemic vector-borne infections, causing serious hazard to humanity. The World Health Organisation (WHO) reported that the incidence of dengue fever has increased dramatically across the world in recent decades. WHO currently estimates an annual incidence of 50–100 million dengue infections worldwide. To date, no tested vaccine or treatment is available to stop or prevent dengue fever. Thus, the importance of predicting dengue outbreaks is significant. The current issue that should be addressed in dengue outbreak prediction is accuracy. A limited number of studies have conducted an in-depth analysis of climate factors in dengue outbreak prediction.

Methods:
The most important climatic factors that contribute to dengue outbreaks were identified in the current work. These factors were used as input parameters for machine learning models. The models were then tested and evaluated on the basis of four-years data (January 2010 to December 2013) collected in Malaysia.

Results:
This research has two major contributions. A new risk factor, called the TempeRain Factor (TRF), was identified and used as an input parameter for the model of dengue outbreak prediction. Moreover, TRF was applied to demonstrate its strong impact on dengue outbreaks. Experimental results showed that the Bayes Network model with the new meteorological risk factor identified in this study increased accuracy to 92.35% and reduced the root-mean-square error to 0.26 for predicting dengue outbreaks.
Ellagic acid produces neuroprotection against LPS-induced dopamine neurotoxicity via the inhibition of microglial NLRP3 inflammasome activation
Authors: He Xue-mei , Yang Qiu-yu , He Jing-yi , Sheng Shuo , Li Jing-jie , Li Dai-di , Wang Guo-qing , Zhang Feng 
Published: November 2019

Abstract
Background: Neuroinflammation plays a crucial role in the pathological process of Parkinson's disease (PD). Nod-like receptor protein 3 (NLRP3) inflammasome was highly located in microglia and involved in the process of neuroinflammation. Activation of NLRP3 inflammasome has been confirmed to contribute to the progression of PD. Thus, inhibition of NLRP3 inflammasomes activation could be an important breakthrough point in PD drug therapy. Ellagic acid (EA) is a natural polyphenol that has been widely found in soft fruits, nuts and other plant tissues with various anti-inflammatory and anti-oxidant properties. However, the mechanisms underlying EA-mediated anti-inflammatory and neuroprotection have not been fully elucidated.﻿Methods: In this study, lipopolysaccharide (LPS)-induced rat dopamine (DA) neuronal damage model was performed to determine the effects of EA on the protection of DA neurons. Furthermore, DA neuron MN9D cell line and microglia BV-2 cell line were employed to explore whether EA-mediated neuroprotection was through an NLRP3-dependent mechanism.Results: EA ameliorated LPS-induced DA neuronal loss in rat substantia nigra. Furtherly, inhibition of microglial NLRP3 inflammasome signaling activation was involved in EA-generated neuroprotection, as evidenced by the following observations. First, EA reduced NLRP3 inflammasome signaling activation in microglia and the subsequent pro-inflammatory cytokines excretion. In addition, EA-mediated anti-neuroinflammation and further DA neuroprotection from LPS-induced neurotoxicity was not shown upon microglial NLRP3 siRNA treatment. Conclusions: This study demonstrated EA has a profound effect on protecting DA neurons against LPS-induced neurotoxicity via the suppression of microglial NLRP3 inflammasome signaling activation.
Social reintegration service after fistula repair and its challenges in North Gondar, Ethiopia: Women’s perspectives: A qualitative study
Authors: Bashah Debrework Tesgera , Worku Abebaw Gebeyehu , Mengistu Mezgebu Yitayal , Azale Telake 
Published: November 2019

Abstract
Back ground: Following a fistula repair, there is a need to rehabilitate and reintegrate women into society. Existing interventions are not well documented or not sufficient to maintain victims’ life and in most cases the issue of reintegration depends up on treatment success. Data on how reintegration has fulfilled women’s needs is sparse. Therefore, the aim of this study was to explore the needs and challenges of women on post obstetric fistula repair.
Method: A qualitative, phenomenological approach was used through in-depth interviews to explore women`s perspectives on reintegration service. Respondents were selected by purposive and snow ball sampling until data saturation was reached. Women were interviewed at least one year after they obtained surgical correction. Open code version 4.03 and thematic analysis was used to analyze the data.
Result: Twelve women after fistula repair were interviewed at different settings; their median age at interview was 27(range 24- 45). Five were fully continent and six claimed to have either stress or urge incontinence. Repair sessions ranged between 1-5surgeries with an average period of 6.25 years after treatment. The meaning attached to reintegration slightly differed between those women who regained continence and those with unsuccessful repair. Surgical correction, resource support and restoration of social health were found to be the most important aspects of the service. Financial difficulty, lack of counseling on fertility needs, lack of individual centered services and residual leaks were commonly reported challenges.
Conclusion: Effective reintegration services should meet women’s needs to the level of their anticipation. Challenges inherent in post repair reintegration require appropriate measures to mitigate dependency, loneliness and the recurrence of fistula.
Potential of improving full vaccination status of children in Niamey, Niger; a randomized cluster survey
Authors: Kunieda Mika , Jimba Masamine , Shibanuma Akira , Manzo Mahamane Laouali 
Published: November 2019

Abstract
Background and Objectives: Economically-disadvantaged Sub-Saharan African children are not fully protected from vaccine-preventable diseases. Maternal education is a promoting factor associated with child vaccination. However, both socio-economic status and maternal education factors are not easily modifiable. This study aimed to identify factors associated with full vaccination status of children in Niamey, Niger.　Methods: A cross-sectional, multi-stage randomized cluster survey was conducted in Niamey’s five health districts. Data on vaccination coverage and socio-economic household characteristics were collected. Logistic regression analysis was conducted with data on 445 pairs of mothers and their children aged 12-23 months.Results: Of 445 children, 38% were fully vaccinated. Mothers who were satisfied with their health worker’s attitude and had correct vaccination calendar knowledge (AOR 5.32, 95% CI 2.05-13.82) were more likely to have fully vaccinated children. Mothers who had completed secondary school (AOR 2.04, 95% CI 1.17-3.55) were also associated with fully vaccinated children. Conclusions: Low coverage of full vaccination could be improved through modifiable factors in resource-limited settings such as Niger. Communication interventions may be effective, including improving mothers’ knowledge about vaccination timing and intervals between appointments. Health workers’ attitudes should also be improved with better interpersonal communication with the mothers.
The effect of remuneration schedule on data completion and retention in the Pregnancy Eating Attributes Study (PEAS)
Authors: Terry Ndeah , Lipsky Leah M. , Siega-Riz Anna Maria , Liu Aiyi , Nansel Tonja R. 
Published: November 2019

Abstract
Background: Maximizing data completion and study retention is essential in population research. There is scant research to inform how remuneration schedules and data collection modality influence participant data completion and retention.

Purpose: We examined the effect of remuneration schedule and data collection modality on data completion and retention in the Pregnancy Eating Attributes Study (PEAS) cohort.

Methods: Participants (n=458) completed self-administered surveys and diet recalls online and attended six study visits. Initially, remuneration was a prespecified amount per visit (lump sum). The remuneration schedule was changed mid-study to be based on the number of forms completed (pro-rated). Survey data collection modality was changed to in-person at the 1-year postpartum visit. Remuneration schedule as a predictor of withdrawal by visit was modeled using

Poisson regression; differences in retention at 1-year postpartum were examined by t-test. Differences in survey and diet record completion were determined by t-test, analysis of covariance, and logistic regression.

Results: There was no significant difference in the time to withdrawal and no interaction of visit with remuneration schedule on withdrawal. Survey and diet recall completion were significantly lower under prorated remuneration at the first visit but did not significantly differ at subsequent visits. Survey completion at 1-year postpartum was significantly higher for in-person versus online completion.

Conclusions: Findings suggest that remuneration schedule and data collection modality can impact completion of self-reported assessments. Further research is needed to understand how remuneration and data collection practices intersect with diverse populations to influence data completion and retention.
Study on the effect of hydrogen sulfide on oxidative stress in renal tubular epithelial cells injured by hypoxia-reoxygenation
Authors: Li Di , Xia Tianyu , Liu Wenli , Li Guangyuan , Zhang Xiaolin , Tan Zhicheng 
Published: November 2019

Abstract
Background: The present study was designed to determine whether exogenous hydrogen sulfide (H 2 S) inhibits oxidative stress in renal tubular epithelial cells under hypoxia-reoxygenation injury. Material and Methods: NRK-52E cells were divided into 4 group, which were Sham group, HR group, NaHS group and DPI group. Using western blotting to detect the protein expression of NOX2 and NOX4 in the process of hypoxia-reoxygenation. Using real-time quantitative PCR to detect the NOX2 and NOX4 mRNA expression in hypoxia-reoxygenation. The fluorescent probe DCFH-DA was used to detect the content of ROS (reactive oxygen species) in cells. The activity of NADPH oxidase was detected by enzyme-linked immunosorbent assay (ELISA). Results: The protein and mRNA expression of NOX2 and NOX4 were significantly increased in the process of hypoxia-reoxygenation, but decreased with NaHS intervention. ROS content and NADPH oxidase activity were all increased in hypoxia-reoxygenation, but decreased after NaHS intervention. Conclusions: H 2 S can reduce ROS production by inhibiting NOX4 and NOX2 during oxidative stress, and also directly inhibits NADPH oxidase activity.
Antiproliferative and Apoptotic Properties of Andrographolide Against Human Colon Cancer DLD1 Cell Line
Authors: Khan Imran , Mahfooz Sadaf , Ansari Irfan A. 
Published: November 2019

Background:
In recent years, natural products have received great attention for cancer prevention
owing to their various health benefits, noticeable lack of toxicity and side effects, and the limitations
of chemotherapeutic agents. Andrographolide, a labdane diterpenoid is a principal bioactive
constituent of Andrographis paniculata Nees, exhibits significant anticancer activity.

Objective:
The efficacy of andrographolide on colon cancer cells is yet to be elucidated completely.
Therefore, we investigated the anticancer efficiency of andrographolide in colon cancer DLD1 cell
line.

Methods:
Antiproliferative activity of andrographolide on DLD1 cells was evaluated by MTT assay,
LDH release assay, morphological analysis and colony formation assay. Induction of apoptosis was
determined by DAPI staining, Annexin V-FITC staining assay, and caspase-3 activation assay. Role of
andrographolide induced cellular reactive oxygen species (ROS) and its association with apoptosis
induction in DLD1 cells was elucidated by DCFDA dye. Synergistic ability of andrographolide with 5-
fluorouracil (5-FU) and paclitaxel (PTX) was evaluated by MTT assay.

Results:
Results of the present study indicated that andrographolide declined cell viability of DLD1
cells in a concentration and time-dependent manner. Andrographolide induced apoptosis via nuclear
condensation, phosphatidylserine externalization and caspase-3 activation. It also augmented cellular
ROS levels which were in turn associated with apoptosis induction in DLD1 cells. Moreover, andrographolide
displayed synergistic activity with 5-FU and PTX against DLD1 cells.

Conclusion:
The present study showed that andrographolide demonstrated antiproliferative and apoptotic
properties, moreover it also displayed synergistic effect with chemotherapeutic drugs in colon
cancer DLD1 cells.