bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Minimally Invasive Endoscopic Technique for Fascia Lata Graft Acquisition and Fascial Reapproximation
Authors: Skoch Jesse , Avila Mauricio J , Fennell Vernard S , Martirosyan Nikolay L , Baaj Ali A , Lemole Gerald M 
Published: July 2020

Abstract

BACKGROUND
Fascia lata remains a popular and robust graft to repair osteodural defects in endoscopic neurosurgery. Classically, this graft is obtained via a large incision in the thigh that is prone to pain and muscle herniation after surgery.

OBJECTIVE
To present a novel technique for harvesting fat and fascia lata graft and reapproximating the edges via an endoscopic approach through the thigh using an “outside-in” technique to prevent muscle herniation.

METHODS
Initially our technique was performed in cadavers and includes the following: small 2 cm incision in the lateral thigh to accommodate the endoscope, use of blunt dissection and endoscopic tools to obtain the graft, and reapproximation of the fascia via an outside-in technique using conventional sutures with endoscopic visualization to retrieve the sutures beneath the skin and tie them. We then applied the technique to a patient undergoing transsphenoidal tumor resection.

RESULTS
This technique was trialed in 3 cadaver specimens (6 limbs) and was used successfully in a patient with excellent cosmetic results seen in follow-up.

CONCLUSION
Endoscopic retrieval of fascia lata is feasible via a very small incision. Reapproximation of the cut fascial edges to minimize muscle herniation can quickly and easily be performed with an outside-in technique detailed here. Additional case series may help to solidify the endoscopic retrieval as a preferred technique for fascia lata graft.
Microsurgical Resection of Cervical Intradural Juxtamedullary Solitary Fibrous Tumor: 2-Dimensional Operative Video
Authors: Perrini Paolo , Di Carlo Davide Tiziano , Montemurro Nicola , Benedetto Nicola , Ortenzi Valerio , Naccarato Antonio Giuseppe 
Published: July 2020

Abstract
Solitary fibrous tumors (SFTs) are uncommon mesenchymal lesions originally described as pleura-based neoplasms. Intradural juxtamedullary SFTs are rare, hard, and scarcely vascularized and generally present a conspicuous extramedullary exophytic component without dural attachment and nerve root involvement. Gross-total resection is the mainstay of treatment, although the absence of an arachnoidal plane and the firm adherence to the spinal cord make resection challenging.
We describe the case of a 74-yr-old female patient presenting with a history of progressive spastic tetraparesis due to a cervical juxtamedullary SFT. The patient was not able to walk and magnetic resonance imaging (MRI) of the cervical spine demonstrated a possible intramedullary lesion at C2-C3 with homogeneous enhancement after gadolinium injection. Given the progressive nature of symptoms, the patient elected to have surgical resection of the tumor. The patient underwent C2-C3 laminoplasty and tumor resection under neurophysiologic monitoring. The tumor presented extremely hard without dural attachment or nerve root involvement and was progressively debulked using microsurgical techniques and ultrasonic aspirator. The identification of a plane between the mass and the spinal cord white matter allowed for a gross total resection. Permanent pathological analysis eventually demonstrated SFT. The patient's neurological condition was unchanged postoperatively. MRI performed 2 mo after the operation demonstrated gross total resection of the lesion. At the 6-mo follow-up visit, the patient was able to walk with assistance.
The patient signed the Institutional Consent Form to undergo the surgical procedure and to allow the use of her images and videos for any type of medical publications.
Development and Validation of the AdT-Physio Scale: A Tool to Assess Adherence and Perception of Physical Therapist Intervention in Patients With Cystic Fibrosis
Authors: del Corral Tamara , La Touche Roy , Cebrià i Iranzo Maria Àngels , Olmos Ricardo , Blanco-Royano Fernando , López-de-Uralde-Villanueva Ibai 
Published: July 2020

Abstract

Objective
The purpose of this study was to develop a scale to measure patient adherence to physical therapist intervention and to report psychometric properties in patients with cystic fibrosis (CF).

Methods
This observational, multicenter, qualitative, and cross-sectional study was divided into 2 phases: development of scale items (content validity) and assessment of psychometric properties (construct validity, reliability, and convergent/discriminant validity). Recruited were 121 patients with CF (aged ≥16 years). Sociodemographic characteristics, lung function testing, Coping with Stress Self-Efficacy, brief Coping Orientation to Problems Experienced inventory, and the scale of Adherence to Treatment of Physiotherapy (AdT-Physio) scale were evaluated.

Results
The final version of the AdT-Physio scale consists of 15 items distributed across 2 subscales: compliance and beliefs about treatment/therapist. The scale showed high internal consistency (Cronbach α = .897; 95% CI = 0.868–0.922) and subscales above 0.800. The 2-factor confirmatory factor analysis model fitted the data reasonably well: χ2 (76) = 111.96, comparative fit index = 0.982, Tucker-Lewis index = 0.978, root mean square error of approximation = 0.063, 95% CI = 0.036 to 0.086, and weighted root mean square residual = 0.720. No floor or ceiling effects were identified. There was a positive, significant, and moderate-low magnitude correlation with the total Coping Orientation to Problems Experienced inventory (r = .360) and Coping with Stress Self-Efficacy subscale efficacy expectations scores (r = .304). For discriminant validity, there was a positive, significant, and moderate correlation between the total and the age of the patients (r = .354).

Conclusions
The AdT-Physio scale is psychometrically valid and reliable for use in the clinic for the assessment of adherence to physical therapy in patients with CF.

Impact
Ultimately, the authors propose this documentary instrument to assess the evaluation of the therapeutic alliance in a valid and objective manner. The AdT-Physio scale provides us with a greater degree of understanding of the problems behind noncompliance with treatment to advance person-centered decisions in physical therapy and thereby enhance the effectiveness of care.
Why Does Equity Capital Flow out of High Tobin’s $\boldsymbol{q}$ Industries?
Authors: Lee Dong Wook , Shin Hyun-Han , Stulz René M 
Published: July 2020

AbstractHigh Tobin’s $q$ industries receive more funding from capital markets than low Tobin’s $q$ industries from 1971 to 1996. Since then, the opposite is true. The key to understanding this shift is that large firms, for which $q$ is more a proxy for rents than investment opportunities, have become more important within industries. For these firms, repurchases but not capital expenditures increase in the cross-section with $q$, so that $q$ explains the variation of repurchases more than of capital expenditures. Consequently, equity capital flows out of high $q$ industries because for these industries stock repurchases are high and issuances are low.
Becoming the North Karelia Project: The Shaping of an Iconic Community Health Intervention in Finland (1970–1977)
Authors: Jauho Mikko 
Published: July 2020

Summary
The article describes the shaping of an iconic public health intervention, the North Karelia Project (NKP) in Finland in the 1970s. NKP is widely hailed as a landmark project, contributing significantly to the development of the community approach to chronic disease prevention. This approach targets comprehensively a specified health problem in a circumscribed area among the whole population, not only high-risk individuals. Based on published and archival material as well as interviews with a few key actors, the article shows how two interlinked tensions shaped the project: the first between rigorous scientific inquiry and politically motivated practical healthcare development in a disadvantaged area and the second between a broad community approach and a focus on individualised health behaviour. These tensions played out in the planning, funding and administrative structure of NKP, were the key source of criticism of it and have affected the possibilities to evaluate its results.
Making Meaning without a Maker: Secular Consciousness through Narrative and Cultural Practice
Authors: Smith Jesse M , Halligan Caitlin L 
Published: July 2020

AbstractDrawing on fieldwork and in-depth interviews, this study examines the ways affirmatively secular individuals construct moral frameworks, navigate hardship, and create meaningful selves. Based on an inductive, thematic analysis of the data, we show that secular individuals’ identities and interpretations of everyday experience and important life events are made meaningful through personal narratives and shared social spaces where cultural values are practiced, imbuing secular worldviews with a sense of legitimacy. Through participants’ responses to questions of “ultimate concern” including life’s purpose, and the meaning of happiness, hardship, and death, we argue that a sense of otherness, appeals to normative values, and the reframing of existential questions in secular terms plays an essential role in the lives of a segment of the growing, increasingly diverse nonreligious community. Our findings have implications for scholars of secularity, including the role of ambiguity in secular beliefs and the importance of narrative in worldview formation.
COVID-19 Pandemic-Related Practices and Policies Affecting the Continuity of Behavioral Health Care Among Children With Diabetes
Authors: Clary Lauren , Wang Christine , Byrne Meghan E , Monaghan Maureen 
Published: July 2020

Abstract
COVID-19 has led to substantial challenges in continuing to deliver behavioral health care to all patients, including children with chronic diseases. In the case of diabetes, maintaining strong connections among children, their families, and their care team is essential to promote and sustain daily adherence to a complex medical regimen. The purpose of this paper is to describe COVID-19 pandemic-related practices and policies affecting the continuity of behavioral health care among children with diabetes. Challenges and opportunities were encountered at the provider, patient, and family levels throughout the rapid transition period from in-person to online care to ensure continuity of services. Institutional, regional, and national policies that impacted the care team’s capacity to respond swiftly to patients’ changing needs were counterbalanced by those related to standards of care, education and training, and resource constraints. At the policy level, COVID-19 re-exposed a number of long-standing and complicated issues about professional licensure among behavioral health providers at the local and state levels and national long-distance practice restrictions during times of crisis. Issues of insurance reimbursement and regulations intended to protect the public may need to adapt and evolve as the practice of behavioral medicine increasingly takes place remotely, online, and over great distances. The sudden transition to telehealth instigated by COVID-19, in addition to the increasing recognition of the benefits of telehealth to favorably affect the reach and impact of traditional behavioral medicine services, offers an unprecedented opportunity to reimagine the medical home and continuity of care for children with diabetes.
X The Seventeenth Century: Part II
Authors: Baker William , Netzley Ryan , Airey Jennifer 
Published: July 2020

Abstract
This chapter has five sections: 1. General; 2. Poetry Excluding Dryden; 3. Restoration Drama Excluding Dryden; 4. Dryden; 5. Poetry and Prose. Section 1 is by William Baker; section 2 is by Ryan Netzley and is divided into six parts: (a) Marvell; (b) Traherne; (c) Vaughan; (d) Cowley; (e) Herrick; (f) Metaphysical and Religious Poets; sections 3 and 4 are by Jennifer Airey; section 5 is by William Baker and is divided into five parts: (a) Hobbes; (b) Locke; (c) Bunyan; (d) Aubrey, Walton, and Bishop Tillotson; (e) Rochester.
LUNG ULTRASOUND FINDINGS IN MEXICAN PATIENTS WITH SARS COV2 INFECTION
Authors: Fernández Luis Fernando Paredes , Martínez Iván Ilescas 
Published: July 2020

ABSTRACTIn late December 2019, a new disease reported at the time by an unknown pathogen was reported, which was later found to be a new variant of coronavirus, now called SARS-CoV2. This new disease had a very rapid global spread, causing multiple deaths in a short time, and which led to putting the entire world on health alert. In patients who have this disease, they present bilateral opacities in frosted multilobar glass with peripheral distribution. Some authors have suggested the use of ultrasound at the point of care for its early recognition.In this study, we evaluated the findings of lung ultrasound in 25 patients admitted to the General Hospital Dr. Enrique Cabrera, Mexico, with a diagnosis confirmed by RT-PCR of SARS CoV2. This small retrospective study suggests that artifacts like glass rockets with or without the Birolleau variant (White lung), confluent B-lines, thick irregular pleural lines, and variable size (subpleural) consolidations are typical findings of lung ultrasound in patients with COVID-19 pneumonia. The presence of these findings is useful when evaluating patients with suspected COVID-19. In resource-limited and austere settings where chest radiography, CT, and RT-PCR are not available or the response time is long, lung ultrasound performed by trained personnel can be an aid in the diagnosis of COVID-19.
High Rate of SARS-CoV-2 Transmission due to Choir Practice in France at the Beginning of the COVID-19 Pandemic
Authors: Charlotte Nathalie 
Published: July 2020

AbstractBackgroundThere has been little focus on the individual risk of acquiring COVID-19 related to choir practice.MethodsWe report the case of a high transmission rate of SARS-CoV-2 linked to an indoor choir rehearsal in France in March 2020 at the beginning of the COVID-19 pandemic.ResultsA total of 27 participants, including 25 male singers, a conductor and an accompanist attended a choir practice on March 12, 2020. The practice was indoor and took place in a non-ventilated space of 45 m2. No choir member reported having been symptomatic for COVID-19 between March 2 and March 12.The mean age of the participants was 66.9 (range 35-86) years. 70% of the participants (19 of 27) were diagnosed with COVID-19 from 1 to 12 days after the rehearsal with a median of 5.1 days. 36% of the cases needed a hospitalization (7/19), and 21% (4/19) were admitted to an ICU. The index cases were possibly multiple.DiscussionThe choir practice was planned in March 2020 at a period when the number of new cases of COVID-19 began to grow exponentially in France because SARS-CoV-2 was actively circulating. The secondary attack rate (70%) was much higher than it is described within households (10-20%) and among close contacts made outside households (0-5%). Singing might have contributed to enhance SARS-CoV-2 person-to-person transmission through emission of droplets and aerosolization in a closed non ventilated space with a relative high number of people including multiple pre-symptomatic suspected index cases.ConclusionIndoor choir practice should be suspended during SARS-CoV-2 outbreaks. Further studies are necessary to test the spread of the virus by the act of singing. As the benefits of the barrier measures and social distancing are known to be effective in terms of a reduction in the incidence of the COVID-19, experts’ recommendations concerning the resuming of choir practice are necessary.
Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium
Authors: Truong Thérèse , Lesueur Fabienne , Sugier Pierre-Emmanuel , Guibon Julie , Xhaard Constance , Karimi Mojgan , Kulkarni Om , Lucotte Elise , Bacq-Daian Delphine , Boland-Auge Anne , Mulot Claire , Laurent-Puig Pierre , Schvartz Claire , Guizard Anne-Valérie , Ren Yan , Adjadj Elisabeth , Rachédi Frédérique , Borson-Chazot Francoise , Ortiz Rosa Maria , Lence-Anta Juan J. , Pereda Celia M. , Comiskey Daniel F. , He Huiling , Liyanarachchi Sandya , de la Chapelle Albert , Elisei Rosella , Gemignani Federica , Thomsen Hauke , Forsti Asta , Herzig Anthony F. , Leutenegger Anne-Louise , Rubino Carole , Ostroumova Evgenia , Kesminiene Ausrele , Boutron-Ruault Marie-Christine , Deleuze Jean-François , Guénel Pascal , de Vathaire Florent 
Published: July 2020

AbstractIncidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. Here, we conducted a genome-wide association study (GWAS) involving 1,554 cases/1,973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from the EPITHYR consortium. Our results confirmed the association with the known DTC susceptibility loci at 2q35, 8p12, 9q22.33 and 14q13.3 in the European ancestry population and suggested two novel signals at 1p31.3 (rs334729) and 16q23.2 (rs16950982), which were associated with TSH levels in previous GWAS. We additionally replicated an association with 5p15.33 reported previously in Chinese and European populations. Except at 1p31.3, all associations were in the same direction in the population of Oceanian ancestry. The frequencies of risk alleles at 2q35, 5p15.33 and 16q23.2 were significantly higher in Oceanians than in Europeans and may explain part of the highest DTC incidence observed in Oceanians.
Interplay of IL6 and CRIM1 on thiopurine-induced neutropenia in leukemic patients with wild-type NUDT15 and TPMT
Authors: Kim Hyery , You Seungwon , Park Yoomi , Choi Jung Yoon , Ma Youngeun , Hong Kyung Tak , Koh Kyung-Nam , Yun Sunmin , Lee Kye Hwa , Shin Hee Young , Lee Suehyun , Yoo Keon Hee , Im Ho Joon , Kang Hyoung Jin , Kim Ju Han 
Published: July 2020

AbstractBackgroundNUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity. Despite recent discovery of homozygous CRIM1 effect on thiopurine toxicity, many patients with wild-type NUDT15, TPMT, and CRIM1 still suffer from thiopurine toxicity, and therapeutic failure and relapse of acute lymphoblastic leukemia (ALL).MethodsNovel PGx interactions associated with thiopurine toxicity in 320 pediatric ALL patients were investigated using whole-exome sequencing technology for the last-cycle 6-Mercaptopurine dose intensity percentage (DIP) tolerated by pediatric ALL patients.ResultsIL6 rs13306435 carriers (N=19) exhibited significantly lower DIP (48.0±27.3%) than non-carriers (N=209, 69.9±29.0%; p=0.0016 and 0.0028 by t-test and multiple linear regression, respectively). Of the 19 carriers, seven with both heterozygous IL6 rs13306435 and CRIM1 rs3821169 showed significantly decreased DIP (24.7±8.9%) than those with IL6 (N=12, 61.6±25.1%) or CRIM1 (N=94, 68.1±28.4%) variant only. Both IL6 and CRIM1 variants showed marked inter-ethnic variability. Significant interplay between IL6 and CRIM1 in thiopurine toxicity was suggested. GVB (Gene-wise Variant Burden)-based four-gene-interplay model showed the best odds ratio (8.06) and potential population impact (i.e., relative risk (5.73), population attributable fraction (58%), number needed to treat (3.67) and number needed to genotype (12.50)).ConclusionsInterplay of IL6 rs13306435 and CRIM1 rs3821169 was suggested as independent and/or additive genetic determinant of thiopurine toxicity beyond NUDT15 and TPMT in pediatric ALL.
TESTING INFORMED SIR BASED EPIDEMIOLOGICAL MODEL FOR COVID-19 IN LUXEMBOURG
Authors: Sauter Thomas , Pacheco Maria Pires 
Published: July 2020

ABSTRACTThe interpretation of the number of COVID-19 cases and deaths in a country or region is strongly dependent on the number of performed tests. We developed a novel SIR based epidemiological model (SIVRT) which allows the country-specific integration of testing information and other available data. The model thereby enables a dynamic inspection of the pandemic and allows estimating key figures, like the number of overall detected and undetected COVID-19 cases and the infection fatality rate. As proof of concept, the novel SIVRT model was used to simulate the first phase of the pandemic in Luxembourg. An overall number of infections of 13.000 and an infection fatality rate of 1,3% was estimated, which is in concordance with data from population-wide testing. Furthermore based on the data as of end of May 2020 and assuming a partial deconfinement, an increase of cases is predicted from mid of July 2020 on. This is consistent with the current observed rise and shows the predictive potential of the novel SIVRT model.
Prospective Observational Study of Screening Asymptomatic Healthcare Workers for SARS-CoV-2 at a Canadian Tertiary Care Center
Authors: Kumar Deepali , Ferreira Victor H. , Chruscinski Andrzej , Kulasingam Vathany , Pugh Trevor J. , Dus Tamara , Wouters Brad , Oza Amit , Ierullo Matthew , Ku Terrance , Majchrzak-Kita Beata , Humar Sonika T. , Bahinskaya Ilona , Pinzon Natalia , Zhang Jianhua , Heisler Lawrence E. , Krzyzanowski Paul M. , Lam Bernard , Lungu Ilinca M. , Manase Dorin , Pace Krista M. , Mashouri Pouria , Brudno Michael , Garrels Michael , Mazzulli Tony , Cybulsky Myron , Humar Atul 
Published: July 2020

ABSTRACTWe screened three separate cohorts of healthcare workers for SARS-CoV-2 via nasopharyngeal swab PCR. A seroprevalence analysis using multiple assays was performed in a subgroup. The asymptomatic health care worker cohorts had a combined swap positivity rate of 29/5776 (0.50%, 95%CI 0.32-0.75) compared to the symptomatic cohort rate of 54/1597 (3.4%) (ratio of symptomatic to asymptomatic 6.8:1). Sequencing demonstrated several variants. The seroprevalence (n=996) was 1.4-3.4% depending on assay. Protein microarray analysis showed differing SARS-CoV-2 protein reactivities and helped define likely true positives vs. suspected false positives. Routine screening of asymptomatic health care workers helps identify a significant proportion of infections.
The Role of Mathematical Model in Curbing COVID-19 in Nigeria
Authors: Madubueze Chinwendu E. , Akabuike Nkiru M. , Dachollom Sambo 
Published: July 2020

AbstractThe role of mathematical models in controlling infectious diseases cannot be overemphasized. COVID-19 is a viral disease that is caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) which has no approved vaccine. The available control measures are non-pharmacological interventions like wearing face masks, social distancing, and lockdown which are being advocated for by the WHO. This work assesses the impact of non-pharmaceutical control measures (social distancing and use of face-masks) and mass testing on the spread of COVID-19 in Nigeria. A community-based transmission model for COVID-19 in Nigeria is formulated with observing social distancing, wearing face masks in public and mass testing. The model is parameterized using Nigeria data on COVID-19 in Nigeria. The basic reproduction number is found to be less than unity(R0< 1) when the compliance with intervention measures is moderate (50% ≤α<70%) and the testing rate per day is moderate (0.5 ≤σ2< 0.7) or when the liance with intervention measures is strict (α≥ 70%) and the testing rate per day is poor (σ2= 0.3). This implies that Nigeria will be able to halt the spread of COVID-19 under these two conditions. However, it will be easier to enforce strict compliance with intervention measures in the presence of poor testing rate due to the limited availability of testing facilities and manpower in Nigeria. Hence, this study advocates that Nigerian governments (Federal and States) should aim at achieving a testing rate of at least 0.3 per day while ensuring that all the citizens strictly comply with wearing face masks and observing social distancing in public.