bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boundary conditions and localization on AdS. Part II. General analysis
Authors: David Justin R. , Gava Edi , Gupta Rajesh Kumar , Narain Kumar 
Published: February 2020

Abstract
We develop the method of Green’s function to evaluate the one loop determinants that arise in localization of supersymmetric field theories on AdS spaces. The theories we study have at least $$ \mathcal{N} $$
N
= 2 supersymmetry and normalisable boundary conditions are consistent with supersymmetry. We then show that under general assumptions the variation of the one loop determinant with respect to the localizing background reduces to a total derivative. Therefore it receives contributions only from the origin of AdS and from asymptotic infinity. From expanding both the Greens function and the quadratic operators at the origin of AdS and asymptotic infinity, we show that the variation of the one loop determinant is proportional to an integer. Furthermore, we show that this integer is an index of a first order differential operator. We demonstrate that these assumptions are valid for Chern-Simons theories coupled to chiral multiplets on AdS2 × S1. Finally we use our results to show that U(Nc) Chern-Simons theory at level k coupled to Nf chiral multiplets and Nf anti-chiral multiplets in the fundamental obeys level-rank duality on AdS2 × S1.
A Killing vector treatment of multiboundary wormholes
Authors: Caceres Elena , Kundu Arnab , Patra Ayan K. , Shashi Sanjit 
Published: February 2020

Abstract
The two-sided BTZ black hole has been instrumental in elucidating several aspects of AdS/CFT. Similarly, multiboundary wormholes provide a useful and rich arena in which probing questions of quantum gravity can be posed and explored. In this work, we find the explicit forms of the Killing vectors needed to construct three-boundary wormholes, with and without rotation, as quotients of AdS3. We ensure that our method captures the full moduli space of such wormholes and elaborate on the generalization of our procedure to more exotic multiboundary spaces, including higher genus.
Evidenz der Kompressionstherapie unter besonderer Berücksichtigung der medizinischen adaptiven Kompressionssysteme
Authors: Dissemond Joachim , Kröger Knut , Stücker Markus 
Published: February 2020

ZusammenfassungDie Kompressionstherapie ist seit mehreren Jahrzehnten eine nebenwirkungsarme Basis für die konservative Behandlung der Patienten mit phlebologischen und lymphologischen Krankheitsbildern. Für die praktische Umsetzung dieser Kompressionstherapie stehen viele verschiedene Materialien mit teilweise systemspezifischen Vor- und Nachteilen zur Verfügung. Eine in Deutschland noch recht neue Behandlungsoption sind medizinische adaptive Kompressionssysteme (MAK). Neben den sehr guten praktischen Erfahrungen im klinischen Alltag zeigt sich auch bei der Zusammenstellung der wissenschaftlichen Evidenz der Kompressionstherapie, dass insbesondere für die Behandlung von Patienten mit Venenerkrankungen die wissenschaftliche Datenlage deutlich besser als für viele andere medizinische Bereiche ist. Wichtig hierbei ist es zu beachten, dass die Kompressionstherapie zuverlässig einen adäquaten Kompressionsdruck gewährleisten muss. Dies vorausgesetzt, ist auf der Basis der aktuell zur Verfügung stehenden Daten davon auszugehen, dass die klinische Effektivität der unterschiedlichen Kompressionssysteme vergleichbar gut ist. Auch für MAK sind diese Aspekte mittlerweile wissenschaftlich gut überprüft worden, sodass diese Analogieschlüsse gezogen werden können. Somit können Therapeuten heute zwischen verschiedenen, sehr effektiven Therapieoptionen wählen und bei der Auswahl individuelle Faktoren, Wünsche der Patienten, aber auch ökonomische Aspekte berücksichtigen.
Do regional self-employment rates converge in the UK? Empirical evidence using club-clustering algorithm
Authors: Saridakis George , Mendoza González Miguel A. , Hand Chris , Muñoz Torres Rebeca I. 
Published: February 2020

AbstractThis paper examines the dynamics of self-employment rates overall and by gender across the UK during the period 2004–2016. Specifically, using the panel convergence methodology suggested by Phillips and Sul (Econometrica 75:1771–1855, 2007) we investigate whether self-employment rates can be characterised by a process where all regions tend to the same equilibrium (global or full convergence) or, if not, whether there are one or more clusters of regions with the same equilibrium (convergence clubs). We find that there is no global regional convergence in total and gender-specific self-employment rates. However, two convergence clubs of regions with lower self-employment rates are found along with a group of non-convergent regions which have higher self-employment rates and somewhat higher rates of growth in self-employment. We also show that gender differences in convergence patterns across UK exist.
Prostaglandin E2 in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8+ T cells
Authors: Gierlich Philipp , Lex Veronika , Technau Antje , Keupp Anne , Morper Lorenz , Glunz Amelie , Sennholz Hanno , Rachor Johannes , Sauer Sascha , Marcu Ana , Grigoleit Götz Ulrich , Wölfl Matthias , Schlegel Paul G. , Eyrich Matthias 
Published: February 2020

AbstractMature dendritic cells (DCs) represent cellular adjuvants for optimal antigen presentation in cancer vaccines. Recently, a combination of prostaglandin E2(PGE2) with Toll-like receptor agonists (TLR-P) was proposed as a new standard to generate superior cytokine-producing DCs with high migratory capacity. Here, we compare TLR-P DCs with conventional DCs matured only with the proinflammatory cytokines TNFα and IL-1ß (CDCs), focussing on the interaction of resulting DCs with CD8+T-cells. TLR-P matured DCs showed elevated expression of activation markers such as CD80 and CD83 compared to CDCs, together with a significantly higher migration capacity. Secretion of IL-6, IL-8, IL-10, and IL-12 was highest after 16 h in TLR-P DCs, and only TLR-P DCs secreted active IL-12p70. TLR-P DCs as well as CDCs successfully primed multifunctional CD8+T-cells from naïve precursors specific for the peptide antigens Melan-A, NLGN4X, and PTP with comparable priming efficacy and T-cell receptor avidity. CD8+T-cells primed by TLR-P DCs showed significantly elevated expression of the integrin VLA-4 and a trend for higher T-cell numbers after expansion. In contrast, TLR-P DCs displayed a substantially reduced capability to cross-present CMVpp65 protein antigen to pp65-specific T cells, an effect that was dose-dependent on PGE2during DC maturation and reproducible with several responder T-cell lines. In conclusion, TLR-P matured DCs might be optimal presenters of antigens not requiring processing such as short peptides. However, PGE2seems less favorable for maturation of DCs intended to process and cross-present more complex vaccine antigens such as lysates, proteins or long peptides.
What is the outcome of the open IPOM versus sublay technique in the treatment of larger incisional hernias?: A propensity score-matched comparison of 9091 patients from the Herniamed Registry
Authors: Köckerling F. , Lammers B. , Weyhe D. , Reinpold W. , Zarras K. , Adolf D. , Riediger H. , Krüger C. M. 
Published: February 2020

Abstract
Introduction
In an Expert Consensus guided by systematic review, the panel agreed that for open elective incisional hernia repair, sublay mesh location is preferred, but open intraperitoneal onlay mesh (IPOM) may be useful in certain settings. This analysis of data from the Herniamed Registry aimed to compare the outcomes of open IPOM and sublay technique.

Methods
Propensity score matching of 9091 patients with elective incisional hernia repair and with defect width ≥ 4 cm was performed. The following matching variables were selected: age, gender, risk factors, ASA score, preoperative pain, defect size, and defect localization.

Results
For the 1977 patients with open IPOM repair and 7114 patients with sublay repair, n = 1938 (98%) pairs were formed. No differences were seen between the two groups with regard to the intraoperative, postoperative and general complications, complication-related reoperations and recurrences. But significant disadvantages were identified for the open IPOM repair in respect of pain on exertion (17.1% vs. 13.7%; p = 0.007), pain at rest (10.4% vs. 8.3%; p = 0.040) and chronic pain requiring treatment (8.8% vs. 5.8%; p < 0.001), in addition to rates of 3.8%, 1.1% and 1.1%, respectively, occurring in both matched patients. No relationship with tacker mesh fixation was identified. There are only very few reports in the literature with comparable findings.

Conclusion
Compared with sublay repair, open IPOM repair appears to pose a higher risk of chronic pain. This finding concords with the Expert Consensus recommending that incisional hernia should preferably be repaired using the sublay technique.
Beyond empathy: a qualitative exploration of arts and humanities in pre-professional (baccalaureate) health education
Authors: Costa Marcela , Kangasjarvi Emilia , Charise Andrea 
Published: February 2020

AbstractFor nearly four decades, researchers have explored the integration of arts and humanities content into health professions education (HPE). However, enduring controversies regarding the purpose, efficacy, and implementation of humanities initiatives suggest that thetimingandcontextof trainees’ exposure to such content is a key, but seldom considered, factor. To better understand the affordances of introducing humanities-based health curriculum prior to the HPE admissions gateway, we conducted a qualitative instrumental case study with participants from Canada’s first Health Humanities baccalaureate program. Fully anonymized transcripts from semi-structured interviews (n = 11) and focus groups (n = 14) underwent an open-coding procedure for thematic narrative analysis to reveal three major temporal domains of described experience (i.e.,prior to, during, andfollowingtheir participation in a 12-week semester-long “Introduction to Health Humanities” course). Our findings demonstrate that perceptions of arts- and humanities content in health education are generated well in advance of HPE admission. Among other findings, we define a new concept—epistemological multicompetence—to describe participants’ emergent capability to toggle between (and advocate for the role of) multiple disciplines, arts and humanities particularly, in health-related teaching and learning at the pre-professional level. Improved coordination of baccalaureate and HPE curricula may therefore enhance the development of capabilities associated with arts and humanities, including: epistemological multicompetence, aesthetic sensibility, and other sought-after qualities in HPE candidates. In conclusion, attending to the pre-professional admissions gateway presents a new, capabilities-driven approach to enhancing both the implementation and critical understanding of arts and humanities’ purpose, role, and effects across the “life course” of health professions education.
Retrospective review of the activity and safety of apatinib and anlotinib in patients with advanced osteosarcoma and soft tissue sarcoma
Authors: Tian Zhichao , Liu Huimin , Zhang Fan , Li Liangyu , Du Xinhui , Li Chao , Yang Jinpo , Wang Jiaqiang 
Published: February 2020

SummaryBackground Previous studies have demonstrated the efficacy of apatinib and anlotinib for the treatment of sarcomas. However, more clinical data and evidence are needed to support clinical treatment selection and study design. Here, we evaluated the effectiveness and safety of these two drugs for the treatment of sarcomas. Methods We retrospectively reviewed the data of 110 patients with advanced osteosarcoma (n = 32) or soft tissue sarcoma (STS, n = 78) who received oral apatinib or anlotinib therapy during May 2016–February 2019 at two centers. Patients were divided into the apatinib and anlotinib groups. Results Among osteosarcoma patients, the objective response rates (ORRs) for the apatinib and anlotinib groups were 15.79% (3/19) and 7.69% (1/13), respectively. The disease control rates (DCRs) were 63.16% (12/19) and 30.77% (4/13), and the median progression-free survival (m-PFS) was 4.67 ± 3.01 and 2.67 ± 1.60 months, respectively. Among STS patients, ORRs for the apatinib and anlotinib groups were 12.24% (6/49) and 13.79% (4/29), respectively. The DCRs were 59.18% (29/49) and 55.17% (16/29), and m-PFS was 7.82 ± 6.90 and 6.03 ± 4.50 months, respectively. Regarding adverse events (AEs), apatinib was associated with a higher incidence of hair hypopigmentation and pneumothorax, while anlotinib was associated with a higher incidence of pharyngalgia or hoarseness. Conclusion Both apatinib and anlotinib were effective for the treatment of sarcomas. However, the effectiveness of the two drugs and associated AEs varied based on the histological type of sarcoma. These differences may be due to their different sensitivities to targets such as RET, warranting further study.
Zum Gesundheitsverhalten älterer Beschäftigter – inwieweit stimmen Selbsteinschätzung und Realität überein?
Authors: Borchart Daniela , Hasselhorn Hans Martin , du Prel Jean-Baptist 
Published: February 2020

Zusammenfassung
Ziel der Studie
Ältere Beschäftigte sind eine besondere Zielgruppe für die Betriebliche Gesundheitsförderung. Eine realistische Einschätzung des eigenen Gesundheitsverhaltens (EGVh) ist wesentlich für die adäquate Anpassung des Gesundheitsverhaltens (GVh) bei Bedarf. Die EGVh kann nach Sozial- und Gesundheitsaspekten variieren. Daher wird untersucht, wie GVh-Faktoren auf die EGVh älterer Beschäftigter nach soziodemografischen Aspekten und der körperlichen Gesundheit (kGes) wirken.

Methodik
Analysiert wurden die Daten von 3347 älteren Beschäftigten der repräsentativen lidA-Studie 2018. Die EGVh wurde mit der Aussage „Ich tue genug für meine Gesundheit“ erfasst. Als GVh-Faktoren wurden die körperliche Aktivität (kA), der BMI und das Rauchverhalten untersucht. Mit hierarchischen logistischen Regressionen wurde der Einfluss der GVh-Faktoren auf die EGVh kontrolliert für Geschlecht, Alter, Bildung und kGes analysiert. Um das Zusammenspiel der unabhängigen Variablen hinsichtlich der EGVh genauer zu untersuchen, wurde zudem auf Interaktionen getestet.

Ergebnisse
Gesündere Verhaltensweisen sind positiv mit der Zustimmung, genug für die eigene Gesundheit zu tun assoziiert. Allerdings zeigten die gefundenen Interaktionen für bestimmte Personengruppen abweichende Ergebnisse. So stimmen übergewichtige Raucher gegenüber normalgewichtigen mit einer höheren Chance der Aussage zu, genug für die eigene Gesundheit zu tun. Bei Nichtaktiven stieg die Zustimmungschance mit abnehmendem Bildungsniveau.

Schlussfolgerung
Die Identifizierung von Personengruppen, die ihre GVh weniger zutreffend einschätzen als andere, kann helfen, das Angebot an Präventionsmaßnahmen bedürfnisspezifischer zu gestalten. Das Zusammenspiel der Einflussfaktoren auf die EGVh gilt es zukünftig noch genauer zu untersuchen.
Integrating site-specific environmental impact assessment in supplier selection: exemplary application to steel procurement
Authors: Schiessl Andreas , Müller Richard , Volk Rebekka , Zimmer Konrad , Breun Patrick , Schultmann Frank 
Published: February 2020

AbstractIn times of fast-growing stakeholder interest in sustainability, the ecological and social perspective of industrial companies and its products is gaining increasing importance. In particular, the emission of greenhouse gases (GHG) in the automotive industry has come to the forefront of public and governmental attention. The transport sector accounts for 27% of all European GHG emissions and constitutes the largest emitter of CO2e (CO2 equivalents) among all energy demanding technologies. Due to increasingly efficient combustion engines and technology innovation towards e-mobility, the emissions from car manufacturing gain in importance. So far little focus has been laid upon the emissions created throughout the production process in automotive supply chains from a purchasing perspective. The purchasing of raw material from environmentally efficient suppliers can constitute a possibility to significantly reduce CO2e emissions in automotive supply chains and thus contribute to the two degrees global warming goal. Supplier selection decisions, which cover approximately 75% of the value adding process of a car, are today mainly cost and quality-driven. In order to integrate CO2e as decision criterion for supplier selections, site-specific and comparable data on CO2e emissions from the upstream supply chain is necessary, but currently lacking. To estimate CO2e emissions of steel suppliers’ production sites, a model has been developed to estimate manufacturing processes on a site-specific level without the necessity of confidential primary data. The model is applied on 22 integrated steel mills in EU-15. The results, which can be transferred and used for various products and industries, e.g. the construction industry, demonstrate the partially large disparities of manufacturing efficiency regarding CO2e emissions among steel manufacturers due to different levels of process integration and internal process know-how. A range between 1879 and 2990 (kg CO2e/t crude steel) has been revealed. Finally, the estimated data on CO2e performance of suppliers is applied in a case study of supplier selection of a German automobile manufacturer in order to simulate environmental as well as economic effects.
Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study
Authors: Zhang Min , Li Guangdi , Shang Jia , Pan Chen , Zhang Minxiang , Yin Zhibiao , Xie Qing , Peng Yanzhong , Mao Qing , Xiao Xinqiang , Jiang Yongfang , Luo Kaizhong , Xu Yun , Ding Hai , Fan Wenzhou , Diego Vidaurre , Pourkarim Mahmoud Reza , De Clercq Erik , Wang Guiqiang , Gong Guozhong 
Published: February 2020

Abstract
Background
As an important anti-HBV drug, pegylated interferon α (PegIFNα) offers promising clinical efficacy, but biomarkers that accurately forecast treatment responses are yet to be elucidated. Here, we evaluated whether HBV RNA could act as an early monitor of pegylated interferon responses.

Methods
We analyzed a phase 3, multicenter, randomized cohort of 727 HBeAg-positive non-cirrhotic patients receiving a 48-week treatment of PegIFNα-2a or PegIFNα-2b and a 24-week treatment-free follow-up. Serum levels of HBV RNA, HBV DNA, HBeAg, and HBsAg were measured at weeks 0, 12, 24, 48, and 72.

Results
HBeAg seroconversion and HBsAg loss at week 72 were observed in 217 (29.8%) and 21 (2.9%) patients, respectively. During the 48-week treatment, HBV RNA decreased more rapidly than HBV DNA and HBsAg, but HBV RNA and HBeAg shared similar dynamics with positive correlations. Multivariate regression analyses consistently revealed the significance of HBV RNA at weeks 0, 12, 24, and 48 to monitor HBeAg seroconversion but not HBsAg loss. Although baseline HBV RNA only showed a modest AUC performance, HBV RNA with a significant increase of AUC at week 12 outperformed other HBV biomarkers to forecast HBeAg seroconversion (p value < 0.05). HBV RNA ≤ 1000 copies/mL was an optimized cutoff at week 12 that offered better prediction than other HBV biomarkers. This optimized cutoff plus patient age, HBV genotype B, and HBeAg offered a strong estimation of HBeAg seroconversion (accuracy 95.2%, true negative rate 99.8%).

Conclusion
HBV RNA at week 12 is an effective monitor of HBeAg seroconversion in HBeAg-positive patients treated with pegylated interferons.
Core, intertwined, and ecosystem-specific clusters in platform ecosystems: analyzing similarities in the digital transformation of the automotive, blockchain, financial, insurance and IIoT industry
Authors: Riasanow Tobias , Jäntgen Lea , Hermes Sebastian , Böhm Markus , Krcmar Helmut 
Published: February 2020

AbstractDigital transformation is continuously changing ecosystems, which also forces established companies to re-evaluate their value proposition. However, only transformations of single ecosystems have been studied. Therefore, this work targets to examine the similarities of digital transformation in five platform ecosystems: automotive, blockchain, financial, insurance, and IIoT. For our analysis, we combine the strengths of conceptual modeling using e3 value with a cluster analysis based on text mining to identify similarities in the respective ecosystems. As a result, we identified 15 clusters. Cluster 01 is the core cluster, containing the roles of organizations from all five ecosystems. Cluster 02–05 are intertwined, as they include roles from at least two ecosystems. Clusters 06–15 are ecosystem-specific that only include roles found in one ecosystem. Scholars and practitioners can use these clusters when analyzing or building a new platform ecosystem, or transforming a traditional ecosystem towards a platform ecosystem.
Lower Tithonian and lower Berriasian brachiopods from the Márévár Limestone Formation, Zengővárkony (Mecsek Mountains Hungary), and remarks on their palaeoenvironment
Authors: Bujtor László , Albrecht Richárd , Maróti Dávid , Miklósy Ákos 
Published: February 2020

AbstractA new collection provided some brachiopods assigned to Lacunosella hoheneggeri, Pygope diphya and P. janitor from the lower Tithonian (Micracanthoceras ponti Zone) and lower Berriasian (Calpionella Zone), and from the limestone succession at Zengővárkony, Mecsek Mountains, Hungary. This is the first taxonomic description and photographic documentation of these fossils. We provide reliable documentation of pygopid brachiopods from the Mecsek Mountains, known since 1880, but previously not described. For the moment, three pygopid brachiopod species are reliably reported from the Mecsek Mountains: Pygope diphya, P. janitor and Pygites diphyioides. The Lacunosella hoheneggeri described herein is the first record of Berriasian rhynchonellide brachiopods from the Mecsek Mountains. The lower Berriasian brachiopods may belong to a normal palaeoenvironment, with the usual size distribution.
Toxizität der Tabakpflanze (Giftpflanze des Jahres 2009)
Authors: Kloft A.-L. , Zulauf N. , Oremek G. M. 
Published: February 2020

ZusammenfassungDie Gattungen Nicotiana tabacum und Nicotiana rustica der Tabakpflanze sind von großer wirtschaftlicher Bedeutung. Aus ihnen wird Tabak hergestellt, der mit Alkohol zur weltweit am häufigsten konsumierten Genussdroge zählt. Aufgrund seiner Legalität wird die Toxizität trotz steigender Warnung und Aufklärung immer noch unterschätzt. Die Toxizität der Tabakpflanze ist vor allem auf das Alkaloid Nikotin zurückzuführen. Dass es selten zu einer Vergiftung durch die reine Pflanze kommt, liegt daran, dass sie optisch kaum zum Verzehr anregt. Häufiger dagegen ist eine Vergiftung durch z. B. verschluckte Zigarettenstummel, die vor allem für Kinder sehr gefährlich sein kann. Eine weitere Gefahr der Vergiftung entsteht bei der Tabakernte. Nikotin wird auch über die Haut aufgenommen und kann so zu der Green Tobacco Sickness bei Tabakplantagenarbeitern führen. Im Ernstfall existiert kein Antidot. Aktivkohle sollte so schnell wie möglich gegeben werden, um die Resorption zu vermindern. Ansonsten muss das Nikotin mit einer Magenwäsche aus dem Körper gefiltert werden. Präventiv sollten deshalb verstärkt auf die Gefahren des Tabaks aufmerksam gemacht werden.