bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectives on Glucocorticoid treatment of COVID-19: a systematic review
Authors: Cordeiro Leonardo P. , Linhares Eduarda O.N.N. , Nogueira Fernanda G.O. , Lima Daniel JM Medeiros 
Published: November 2020

Abstract
Coronavirus disease 2019 (COVID-19) is an on-going pandemic, this viral pneumonia can lead to a severe acute respiratory syndrome (SARS). Until the commercialization of a vaccine, pharmacological treatment still represents a great strategy to fight the disease. Glucocorticoids (GC) were widely used in the past coronavirus pandemics and it’s been also used against the SARS-CoV-2. The aim of this study was to review the articles available about the use of GC in patients with COVID-19. In this systematic review randomized or nonrandomized clinical trials and retrospective or prospective controlled longitudinal studies were accepted. Participants could be of any clinical status, geographic location, age and sex. Studies in English, Portuguese and Spanish published since 2019 were included. The focuses of greatest interest were related to length of stay, changes in the radiological profile, viremia and mortality. The research was done electronically on the Pubmed database with the following terms: “corticosteroids”, “glucocorticoids”, “dexamethasone”, “methylprednisolone”, “COVID-19”, “Sars- CoV-2”, “ADRS”. We identified 6,332 publications and at the end 14 were used since they met all inclusion criteria. All of them are retrospective observational studies. These studies included only patients infected with SARS-CoV-2 confirmed by RT-PCR, involving 2,713 participants. The results showed great heterogeneity in their designs and results, which precludes a reliable conclusion on the use of GCs in the treatment of COVID-19.
Prevalence and factors associated with sexual violence among rural women aged&nbsp;15-49 years in Uganda: evidence from the Uganda demographic and health survey 2016
Authors: Kawuki Joseph , Sserwanja Quraish , Mukunya David , Sepenu Abigail Sitsope , Musaba Milton 
Published: November 2020

Abstract
Background and Aim: Sexual violence is a serious global health problem with short and long-term physical, mental, and reproductive adverse-effects. We aimed to determine the prevalence and factors associated with sexual violence among rural women of reproductive age in Uganda.Methods: We used the Uganda Demographic and Health Survey (UDHS) 2016 data for 5,259 rural women aged 15 to 49 years. Multi-stage stratified sampling was used to select respondents, and data were collected using validated questionnaires. We used multivariable logistic regression to determine factors associated with sexual violence. All analyses we carried out in SPSS (version 25). Results: The overall prevalence of sexual violence was 24.3% (95% CI: 23.4-25.7), while that among pregnant women was 22.2% (95% CI: 19.1-25.6). Women of primary education had higher odds of sexual violence compared to those of tertiary education (AOR=3.01, 95% CI: 1.17-7.72), and those from the Western region compared to those in the Northern region (AORs=2.01, 95% CI: 1.41-2.87). Women of poorer wealth quintile also had higher odds of sexual violence compared to those of the richest quintile (AOR=2.06, 95% CI: 1.02-4.17). Higher odds of sexual violence were also found among women who justified beating (AOR=1.42, 95% CI: 1.12-1.79), those who were not involved in healthcare decision-making (AOR=1.38, 95% CI: 1.01-1.91), and those whose husbands often got drunk (AOR=2.07, 95% CI: 1.30-3.31), compared to their counterparts.Conclusions: The prevalence of sexual violence among rural women in Uganda was high and associated with factors such as education level, region, wealth index, justified beating, healthcare decision making, and husband drunk frequency. Thus, there is a need for improving livelihoods and income of rural women, promotion of girl-child education as well as strengthening protective laws and policies to curb this public health issue.
Assessment of compliance between a local “patients transportation protocol” and the latest European Consensus Recommendations for pediatric and neonatal retrieval in a COVID-19 context
Authors: Dubois Cecile , Ruetsch Valerie , Barreault Simon , Ollier Vincent , Jourdain Gilles 
Published: November 2020

Abstract
As the COVID-19 pandemic evolves in Europe, safe transport of critically ill children challenged our retrieval team. In early July, recommendations for the transport of suspected or confirmed COVID-19 patients were published. Our study aimed to assess, retrospectively, if the recommendations were followed by our team. From the start of the current COVID-19 pandemic, our team developed transport procedures to protect health-care workers and to minimize nosocomial spread. The European Society of Pediatric Neonatal Intensive Care recommendations were made of a bunch of 17 elements. We extracted from our database all transports of suspected or confirmed COVID-19 from 1st of March to 31th of May and compared for each transports the agreement with the 17 recommendations. Out of the 31 children that met the inclusion criteria, 29 were transported by our unit. Five recommendations were not applicable and therefore not discussed. Of the 12 recommendations remaining, 3 were not endorsed by our team: regarding the parental presence during retrieval, wearing a surgical mask for patient and the use of a dedicated pathway at arrival.﻿Conclusion: Most of the European recommendations were fully endorsed by our local retrieval team, but we have to improve our attitude in some aspects.
Computationally approached inhibition potential of Tinospora Cordifolia towards COVID-19 targets
Authors: Jena Sushovan , Munusami Punnagai , MM Balamurali , Chanda Kaushik 
Published: November 2020

Abstract
The recent emergence of novel coronavirus (SARS-CoV-2) has been a major threat to human society, as the challenge of finding a suitable drug or vaccine is not met till date. With increasing morbidity and mortality, the need for novel drug candidates is under great demand. The investigations are progressing towards COVID-19 therapeutics and among the various strategies employed, the use of repurposed drugs is competing along with novel drug inventions [1]. Based on the therapeutic significance, the chemical constituents from the extract of Tinospora Cordifolia belonging to various classes like alkaloids, lignans, steroids and terpenoids will be investigated as potential drug candidates for COVID-19. The inhibition potential of the proposed compounds against viral spike protein and human receptor ACE2 were evaluated by computational molecular modeling (Auto dock), along with their ADME/T properties. Prior to docking, the initial geometry of the compounds were optimized by Density functional theory (DFT) method employing B3LYP hybrid functional and 6-311++G (d,p) basis set. The results of molecular docking and ADME/T studies have revealed 6 constituents as potential drug candidates that can inhibit the binding of SARS-CoV-2 spike protein with the human receptor ACE2 protein. The narrowed down list of constituents from Tinospora Cordifolia have paved way for further tuning their ability to inhibit COVID-19 by modifying the chemical structures and by employing computational geometry optimization and docking methods.
Prevalence and Associated Factors of Intimate Partner Violence (IPV) against Women in Bangladesh amid COVID-19 Pandemic
Authors: Rayhan Istihak , Akter Khaleda 
Published: November 2020

Abstract
Background: The study attempted to explore the prevalence and associated factors of Intimate Partner Violence (IPV) in Bangladesh amid the COVID-19 pandemic. IPV is a complete violation of women's human rights and a dominant chronic global public health problem. Methods: The target population of the study was Bangladeshi married women, aged between 16 to 49 years, and lived with an intimate partner. Data were collected from Dhaka city with eight other districts of Bangladesh, and among 605 married women response rate was 84.30%. WHO multi-country study tools for screening domestic violence were used to screen emotional, physical, and sexual violence. Results: The study found the prevalence of IPV about 45.29%, where emotionally abused 44.12%, physically 15.29%, sexually 10.59%, and either physically or sexually 19.22%. Adjusted with marital duration, residence, women’s level of education, husband’s age, and monthly family income, multivariate logistic regression results revealed that comparatively older women, employed, non-Muslims and women with educated husband were less likely to experience violence, while arranged marriage, family income reduction amid the pandemic and husbands’ pandemic induced depression or anxiety caused more likely to commit violence. Limitations: Self-reported cross-sectional study has some methodological limitations, and the present study is not free from them. Conclusions: The study contributes to the existing literature by highlighting the associated factors of IPV amid the COVID-19 pandemic, which will help to make preventive policy.
Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity
Authors: Taheri Ehsaneh , Hosseini Saeed , Qorbani Mostafa , Mirmiran Parvin 
Published: November 2020

Abstract
Background: Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.Methods: Forty women with body mass index (BMI) = 18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range, and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and circulating levels of leptin and vaspin were measured.Results: The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had the higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. The serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, the serum levels of leptin had positive correlation with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06), positively.Conclusion: It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher concentrations of leptin and vaspin in the NWO group were associated with glycemic profile.
Attendants’ experience with the Personalized citizen assistance for social participation (APIC)
Authors: Gagnon Karine , Levasseur Mélanie 
Published: November 2020

Abstract
Background: To promote healthy aging, the social participation needs of older adults must be better met. Previous studies have shown the benefits of the Personalized citizen assistance for social participation (APIC), but few explored its influence on attendants. This study explored the assistance experience of attendants in providing the APIC to older adults with disabilities. Methods: A qualitative design inspired by a phenomenological approach was used with six female attendants who participated in individual interviews. Results: The APIC attendants felt useful, developed meaningful relationships with their older adults, and improved their self-knowledge. Attendants had the opportunity to reflect on their lives and self-aging. They contributed to older adults’ functional independence, motivation, and participation in social activities. Attendants encountered challenges related to withdrawn behavior in older adults, such as refusing to participate in activities. Conclusions: Considering the identified benefits of the APIC for attendants, further studies should explore personalized assistance to preserve older adults’ health.
Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
Authors: Liu Wenhui , La A La Teng Zhu , Evans Alexander , Gao Shengtao , Yu Zhongtang , Bu Dengpan , Ma Lu 
Published: November 2020

Abstract
Background: There is increasing research interest in using short-chain fatty acids (SCFAs) including butyrate as potential alternatives to antibiotic growth promoters in animal production. This study was conducted to evaluate the effects of supplementation of sodium butyrate (SB) in liquid feeds (milk, milk replacer, and the mixture of both) on the growth performance, rumen fermentation, and serum antioxidant capacity and immunoglobins in dairy calves before weaning. Forty healthy female Holstein calves (4-day-old, 40 ± 5 kg of body weight) were housed in individual hutches and randomly allocated to 1 of 4 treatment groups (n = 10 per group) using the RAND function in Excel. The control group was fed no SB (SB0), while the other three groups were supplemented with 15 (SB15), 30 (SB30), or 45 (SB45) g per day of SB mixed into liquid feeds offered. The calves were initially fed milk only (days 2 to 20), then a mixture of milk and milk replacer (days 21 to 23), and finally milk replacer only (days 24 to 60).Results: The SB supplementation enhanced growth and improved feed conversion into body weight gain compared with the SB0 group，and the average daily gain increased quadratically with increasing SB supplementation. No significant effect on rumen pH; concentrations of NH3-N, individual and total VFAs; or acetate: propionate (A:P) ratio was found during the whole experimental period. Serum glutathione peroxidase activity increased linearly with the increased SB supplementation, while the serum concentration of maleic dialdehyde linearly decreased. Serum concentrations of immunoglobulin A, immunoglobulin G, or immunoglobulin M were not affected by the SB supplementation during the whole experimental period. Conclusions: Under the conditions of this study, SB supplementation improved growth performance and antioxidant function in pre-weaned dairy calves. We recommended 45 g per day as the optimal level of SB supplementation mixed into liquid feeds (milk or milk replacer) to improve the growth and antioxidant function of dairy calves before weaning.
The emerging COVID-19 research: dynamic and regularly updated science maps and analyses
Authors: Andersen Njål , Bramness Jørgen Gustav , Lund Ingunn Olea 
Published: November 2020

Abstract
Background: The COVID-19 pandemic is a global public health emergency and experts emphasize the need for rapid and a high degree of communication and interaction between all parties, in order for critical research to be implemented. We introduce a resource (website) that provides bibliometric analysis showing the current content and structure of the published literature. As new research is published daily, the analysis is regularly updated to show the status as the research field develops and matures.Methods: Two bibliometric methods were employed, the first is a key-word co-occurrence analysis, based on published work available from PubMed. The second is a bibliometric coupling analysis, based on articles available through Scopus. The results are presented as clustered network graphs; available as interactive network graphs through the webpage.Results: For research as of March 23rd, keyword co-occurrence analysis showed that research was organized in 4 topic clusters: “Health and pandemic management”, “The disease and its pathophysiology”, “Clinical epidemiology of the disease” and “Treatment of the disease”. Coupling analyses resulted in 4 clusters on literature that relates to “Overview of the new virus”, “Clinical medicine”, “On the virus” and “Reproduction rate and spread”.Conclusions: We introduced a dynamic resource that will give a wide readership an overview of how the structure of the COVID-19 literature is developing. To illustrate what this can look like, we showed the structure as it stands three months after the virus was identified; the structure is likely to change as we progress to later stages of this pandemic.
Retrospective cohort study of nanoparticle albumin-bound paclitaxel plus ramucirumab versus paclitaxel plus ramucirumab as second-line treatment in patients with advanced gastric cancer
Authors: Okunaka Mashiro , Kotani Daisuke , Demachi Ken , Kawazoe Akihito , Yoshino Takayuki , Kawasaki Toshikatsu , Shitara Kohei 
Published: November 2020

Abstract
Background: Nanoparticle albumin-bound paclitaxel (nab-PTX) has shown non-inferiority to paclitaxel (PTX) as second-line therapy for advanced gastric cancer (AGC) with fewer infusion-related reactions. The efficacy and safety of nab-PTX plus ramucirumab (RAM) was reported in a phase II trial; however, there is no randomized trial comparing this regimen with PTX plus RAM in patients with AGC. This retrospective study aimed to investigate the efficacy and safety of nab-PTX plus RAM versus PTX plus RAM in patients with AGC.Methods: This study included patients with AGC who received nab-PTX plus RAM from September 2017 to January 2019 or PTX plus RAM from June 2015 to August 2017 as second-line chemotherapy in our hospital.Results: A total of 113 and 138 patients who received nab-PTX plus RAM and PTX plus RAM, respectively, were analyzed. Median progression-free survival (PFS) was 3.9 months (95% confidence interval [CI]: 3.4–4.3) in the nab-PTX plus RAM group and 3.9 months (95% CI: 3.1–4.7) in the PTX plus RAM group (hazard ratio [HR]: 1.08; 95% CI: 0.83–1.40; P = 0.573). Median overall survival (OS) was 10.9 months (95% CI: 9.3–12.7) in the nab-PTX plus RAM group and 10.3 months (95% CI: 8.5–12.0) in the PTX plus RAM group (hazard ratio: 0.82; 95% CI: 0.61–1.10; P = 0.188). In patients with moderate/massive ascites, favorable outcomes for progression-free survival were observed in the nab-PTX plus RAM group compared with the PTX plus RAM group. Although anemia and fatigue (any grade) were more frequent in the nab-PTX plus RAM group, discontinuation of study treatment was not increased in the nab-PTX plus RAM group. There was no occurrence of hypersensitivity reaction in the nab-PTX plus RAM group, while two patients (1.4%) experienced grade 3 hypersensitivity reactions in the PTX plus RAM group.Conclusions: The combination of nab-PTX plus RAM showed a similar efficacy and safety profile to PTX plus RAM as second-line treatment for patients with AGC.
A gene-based risk score model for predicting recurrence-free survival in patients with hepatocellular carcinoma
Authors: WANG WENHUA , WANG LINGCHEN , XIE XINSHENG , YAN YEHONG , LI YUE , LU QUQIN 
Published: November 2020

Abstract
BackgroundHepatocellular carcinoma (HCC) remains the most frequent liver cancer, accounting for approximately 90% of primary liver cancers worldwide. The recurrence-free survival (RFS) of HCC patients is a critical factor in devising a personal treatment plan. Thus, it is necessary to accurately forecast the prognosis of HCC patients in clinical practice.MethodsUsing The Cancer Genome Atlas (TCGA) dataset, we identified genes associated with RFS. A robust likelihood-based survival modeling approach was used to select the best genes for the prognostic model. Then, the GSE76427 dataset was used to evaluate the prognostic model’s effectiveness.ResultsWe identified 1331 differentially expressed genes associated with RFS. Seven of these genes were selected to generate the prognostic model. The validation in both the TCGA cohort and GEO cohort demonstrated that the 7-gene prognostic model can predict the RFS of HCC patients. Meanwhile, the results of the multivariate Cox regression analysis showed that the 7-gene risk score model could function as an independent prognostic factor. In addition, according to the time-dependent ROC curve, the 7-gene risk score model performed better in predicting the RFS of the training set and the external validation dataset than the classical TNM staging and BCLC. Furthermore, these seven genes were found to be related to the occurrence and development of liver cancer by exploring three other databases.ConclusionOur study identified a seven-gene signature for HCC RFS prediction that can be used as a novel and convenient prognostic tool. These seven genes might be potential target genes for metabolic therapy and the treatment of HCC.
Altered expression profile of BAFF receptors on peripheral blood B lymphocytes in Graves’ Disease
Authors: Wang Xin , Huang Jinhui , Zhang Aixia , Fang Chen , Ma Qi , Jiang Penjun 
Published: November 2020

Abstract
Background: B lymphocyte activating factor (BAFF) is a growth factor regulating B lymphocytes survival and maturation. Serum BAFF levels were elevated in patients affected with autoimmune thyroid diseases (AITD), including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). The aim of this study is to investigate the association of expression of BAFF receptors on the peripheral blood B lymphocytes in addition to serum BAFF concentrations in patients affected with GD.Methods: Fifty-two GD patients, 39 Hashimoto’s thyroiditis (HT) patients and 23 healthy controls (HC) were recruited in this study. Serum BAFF levels and its receptors expression, including BAFF receptor 3 (BR3) and transmembrane activator and calcium-modulating and cyclophilin ligand interactor (TACI), in AITD patients were compared to those in HC. In 10 patients with Graves’ orbitopathy (GO) receiving steroids therapy, effects of steroids on serum BAFF levels and expression of BR3 and TACI were observed.Results: Serum BAFF levels were significantly elevated from 0.93 ± 0.24 ng/ml in HC to 1.18 ± 0.33 ng/ml in GD ( P =0.0027) and 1.02 ± 0.24 ng/ml in HT ( P =0.0331). BR3 expression on peripheral B lymphocytes were elevated in GD (mean MFI: 4.52 ± 2.06 in GD vs 3.00 ± 0.87 in HC, P =0.0015), while TACI expression on peripheral B lymphocytes were decreased in GD without significance (mean MFI: 7.96 ± 4.06 in GD vs 9.10 ± 3.37 in HC, P =0.1285). Expression of BR3 and TACI was not changed significantly in HT patients. Steroids significantly suppressed serum BAFF concentrations (from 1.18 ± 0.27 ng/ml to 0.97 ± 0.10 ng/ml, P =0.0364) and BR3 expression in GO patients (mean MFI from 6.26 ± 4.91 to 4.05 ± 1.58, P =0.0083). Conclusions: Altered expression of BAFF and its receptor may mediate the autoimmunity in GD. Restoring the normal expression profile of receptors for BAFF could be a new strategy to treat GD.