bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turning machinability of alloyed ductile iron compared to forged EN 1.7131 steel
Authors: Tanabi Hamed , Rafighi Mohammad 
Published: December 2020

Abstract
Recently, many applications have used austempered ductile iron due to its high hardness, strength, toughness, and wear resistance. These superior properties make austempered ductile iron an alternative material to forged steels. However, machining of austempered ductile iron is challenging because of its high hardness and strength. In this study, machining operations were performed on the alloyed ductile iron workpiece to investigate the machinability of the material prior to the austempering process. This experimental study was carried out on EN 1.7131 alloy steel and alloyed ductile iron using single point carbide inserts under dry cutting conditions. A constant feed of 0.1 mm × rev-1, constant depth of cut of 1 mm, and variable cutting speeds were selected as input parameters, whereas tool life is considered as a response parameter. The tool life tests were accomplished considering flank wear as tool life criterion according to ISO 3685. The results of this study indicated that although the machinability of ductile iron is 88 % of the normalized forged EN 1.7131 steel for a 60 minutes’ tool life, identical tool life was observed for both materials at 96 m × min-1cutting speeds.
Sistem Pengukuran Volume Cairan Pada Tangki Pembuburan Kertas
Authors: Desmira  , Aribowo Didik , Pramana Rozeff 
Published: December 2020

Pada proses pembuburan kertas merupakan suatu proses penghancuran lembaran menjadi buburan. Penelitian ini bertujuan 1) Mengetahui proses sensor dalam pembuburan kertas di Paper Machine (PM) dibagian rewinder. 2) Mengetahui hasil kekentalan pada pembuburan kertas dengan sensor yang disetting nilai Set-pointnya. 3) Menganalisa hasil penggunaan sensor yang digunakan pada proses pembuburan kertas di Paper Machine (PM) dibagian rewinder. Adapun intruksi-intruksi yang diberikan pada mesin agar bekerja dalam proses pembuburan kertas yang disebut sebagai system logic control pada DCS untuk memberikan perintah dan mengeksekusi mesin dan actuator bekerja. Metode pembahasan digunakan yaitu research and development . Hasil yang diperoleh me-nyesuaikan kekentalan pada proses pembuburan kertas dengan set point 4% sehingga kertas yang dibentuk akan sesuai dengan apa yang diinginkan dan menghasilkan kertas yang baik, melalui alat berupa consistency transmitter yang dipasang di tangki tempat buburan kertas. Dari hasil penelitian dapat disimpulkan jika nilai set point kurang dari 4% maka hasil akan kurang baik sedangkan dengan set point yaitu 4% maka hasil akan baik.
Evaluation of knowledge, attitude and practice towards corona virus disease 2019 (COVID-19) among second year medical students in post lockdown period: A quick online questionnaire based study
Authors: Baheti Ashishkumar , Chimurkar Leena , Varma Sushilkumar 
Published: December 2020

Background: The year 2019–2020 has seen a worldwide pandemic resulting from corona virus disease 2019 (COVID‑19), which can result in illnesses ranging from the common cold to severe acute respiratory syndrome (SARS). Hence, this global health crisis of COVID‑19 pandemic offers a unique opportunity to evaluate knowledge, attitude, and practice among medical students.
Methods: This prospective, web‑based, cross‑sectional study was conducted among 100
undergraduate medical students after obtaining informed consent during first week of August 2020 using a 37-items structured questionnaire based on the Ministry of Health and Family welfare course materials and was distributed using Google forms. All the tests were performed at a significance level of 5%.
Results: Overall, the study participants’ knowledge regarding COVID‑19 was satisfactory they have positive attitude and they followed healthy preventive practices also. There was no significant difference found among male and females in knowledge and practice however attitude score was affected by gender.
Conclusions: Most medical students had satisfactory knowledge levels, and discrepancies in the perceptions of COVID‑19, thus, with adequate training and counseling undergraduate medical students via structured teaching program, most medical students can act as a potential reservoir to fill the gaps in health‑care services in the hour of need.
Keywords: COVID-19, Knowledge, attitude, Practice, Medical students, questionnaire
Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated <i>E. coli</i> asparaginase in children with acute lymphocytic leukemia
Authors: Khalil Alaeddin , Würthwein Gudrun , Golitsch Jana , Hempel Georg , Fobker Manfred , Gerss Joachim , Möricke Anja , Zimmermann Martin , Smisek Petr , Zucchetti Massimo , Nath Christa , Attarbaschi Andishe , Von Stackelberg Arend , Gökbuget Nicola , Rizzari Carmelo , Conter Valentino , Schrappe Martin , Boos Joachim , Lanvers-Kaminsky Claudia 
Published: December 2020

Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. We evaluated the prevalence of antibodies against PEG among patients with acute lymphoblastic leukemia (ALL) prior to and/or immediately after their first dose of pegylated E.coli asparaginase (PEG-ASNase). Serum samples of 701 children, 673 with primary ALL, 28 with relapsed ALL, and 188 adults with primary ALL were analyzed for anti-PEG IgG and IgM. Measurements in 58 healthy infants served as reference to define cut-points for antibody-positive and -negative samples. Anti-PEG antibodies were detected in ALL patients prior the first PEG-ASNase with a prevalence of 13.9% (anti-PEG IgG) and 29.1% (anti-PEG IgM). After administration of PEG-ASNase the prevalence of anti-PEG antibodies decreased to 4.2% for anti-PEG IgG and to 4.5% for anti-PEG IgM. Pre-existing anti-PEG antibodies did not inhibit PEG-ASNase activity but significantly reduced PEGASNase activity levels in a concentration dependent manner. Although pre-existing anti-PEG antibodies did not boost, pre-existing anti-PEG IgG were significantly associated with firstexposure hypersensitivity reactions (CTCAE grade 2) (p<0.01; Fisher’s exact test). Two of 4 patients with pre-existing anti-PEG IgG and first-exposure hypersensitivity reactions were not switched to Erwinia ASNase and continued on PEG-ASNase with sufficient activities (≥100U/L).
Pre-existing anti-PEG antibodies were detected in a considerable proportion of patients with ALL, did not inhibit PEG-ASNase activity but were associated with lower serum PEGASNase activity levels. Patients with pre-existing antibodies may show mild to moderate signs of hypersensitivity reaction after their first PEG-ASNase, which may be successfully addressed by re-challenge.
Socioeconomic impact of migraine in Italy: Results of a national survey
Authors: Nica Mihaela , Colombo Delia , Ravasio Roberto , Rognoni Carla 
Published: December 2020

Background: Literature data indicate that migraine has a stronger impact on both healthcare consumption and quality of life (QoL) in women.
Objectives: The objective of this article is to evaluate out-of-pocket (OoP) costs, productivity losses and cost of informal care of migraine in Italy, with a special focus on the detection of potential differences between male and female subjects.
Methods: A cross-sectional study was conducted. Data were collected via a web-based survey platform, which included a socioeconomic questionnaire (five sections: clinical history; occupational status; informal assistance; visits, exams and treatments; and loss of productivity) and two questionnaires on QoL (EuroQol 5D 5L and Migraine-Specific Questionnaire, MSQ).
Results: Six hundred and seven participants took part in the survey (average age of 42 years; female 70%). The duration of the attack (4-72 hours) was significantly much longer in women than in men (71% vs. 49%; p < 0.001). Seventy per cent of the sample reported to be employed. Lower income was associated with women (p < 0.001). Men received more informal assistance days than women (5.2 vs. 3.9 days; p = 0.007). The quarterly cost including OoP costs, informal assistance and lost productivity averaged €1,088 and was higher for men compared to women (€1,515 vs. €908; p < 0.001). The MSQ reported a significantly worse QoL for women.
Conclusion: The results seemed to prove that migraine is a gender disease. Moreover, a potentially unequal access to informal assistance and healthcare resources not covered by the Italian National Health Service is highlighted for women because of their lower average income and purchasing power compared to men.
FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration
Authors: Ge Jun , Wang Yingjie , Yan Qi , Wu Cenhao , Yu Hao , Yang Huilin , Zou Jun 
Published: December 2020

BackgroundIntervertebral disk (IVD) degeneration is the most common cause of lower back pain. Inhibiting inflammation is a key strategy for delaying IVD degeneration. Tacrolimus (FK506) is a potent immunosuppressive agent that is also beneficial to chondrocytes via alleviating inflammation. However, the potential function of FK506 in IVD and the underlying mechanisms remain unknown. The current study is aim at exploring the underlying mechanism of FK506 in preventing IVD degeneration.MethodsCell morphology was imaged using an optical microscope. mRNA levels of nucleus pulposus (NP) matrix components were determined by qRT-PCR, and protein expression NP matrix components was assessed by western blotting. A rat caudal IVD degeneration model was established to test for FK506 in vivo.ResultsFK506 improved the morphology of NP cells and the cell function at both the mRNA and protein level. FK506 could attenuate NP degeneration induced by IL-1β. Furthermore, FK506 exerted its function via TGFβ/Smad3 activation instead of through calcineurin inhibition. Inhibition of the TGF-β pathway prevented the protective effect of FK506 on IVD degeneration. In an in vivo study, FK506 injection reversed the development of rat caudal IVD degeneration influenced by Smad3.ConclusionOur current study demonstrates the positive effect of FK506 on delaying the degeneration of IVD via the TGFβ/Smad3 pathway.
Prevalence and Prognostic Significance of Frailty in Gerontal Inpatients With Pre-clinical Heart Failure: A Subgroup Analysis of a Prospective Observational Cohort Study in China
Authors: Zheng Pei-Pei , Yao Si-Min , Shi Jing , Wan Yu-Hao , Guo Di , Cui Ling-Ling , Sun Ning , Wang Hua , Yang Jie-Fu 
Published: December 2020

Objective: To evaluate the prognostic value of frailty in gerontal pre-clinical heart failure (stage B heart failure, SBHF) inpatients.Background: The association between frailty and SBHF remains unknown.Methods: We conducted a subgroup analysis of a prospective observational cohort study on frailty. The previous study recruited 1,000 elderly inpatients who were consecutively admitted to a tertiary referral hospital in Beijing, China, from September 2018 to February 2019. The outcomes were all-cause death or readmission at 1-year follow-up. SBHF was diagnosed for asymptomatic cardiac structural or functional abnormalities. Frailty was assessed using the Comprehensive Geriatric Assessment-Frailty Index (CGA-FI).Results: Overall, 531 inpatients aged ≥65 years were deemed to have SBHF and followed up for 1 year. Of them, 34.5% exhibited frailty. During the follow-up period, all-cause death or readmission occurred in 157 (29.5%) participants. Of these participants, 36.6% (67/183) and 25.9% (90/348) belonged to the frail and non-frail groups, respectively (χ2 = 6.655, P = 0.010). Frailty, defined by the CGA-FI, rather than Fried frailty phenotype, could independently predict 1-year all-cause death or readmission (hazard ratio, 1.56; 95% confidence interval, 1.03–2.35; P = 0.034) and was more suitable for predicting all-cause death or readmission than N-terminal pro-B-type natriuretic peptide in female SBHF inpatients aged 80 years or over(AUCCGA−FI vs. AUCNT−proBNP 0.654 vs. 0.575, P = 0.017).Conclusions: Frailty is highly prevalent even among SBHF inpatients aged ≥65 years. The CGA-FI can independently predict 1-year all-cause death or readmission, rather than Fried frailty phenotype. Frailty in gerontal SBHF inpatients deserves more attention.Clinical Trial registration: ChiCTR1800017204; date of registration: 07/18/2018.
Mineralogy of Nickel and Cobalt Minerals in Xiarihamu Nickel–Cobalt Deposit, East Kunlun Orogen, China
Authors: Han Yixiao , Liu Yunhua , Li Wenyuan 
Published: December 2020

Located in the East Kunlun Orogen, China, the Xiarihamu magmatic nickel–cobalt sulfide deposit is the country’s second largest deposit of this type. It was formed in special early Paleozoic with low copper grade (0.14 wt%) compared with other deposits of the same type. The mineralogy of nickel and cobalt minerals, which are direct carriers of these elements, can clearly reflect their behavior in the process of mineralization; however, such information for this deposit remains unreported. In the present study, we use an electron microscope and electron probe microanalyzer to delineate and analyze many nickel and cobalt minerals such as maucherite, nickeline, cobaltite, violarite, gersdorffite, parkerite, and arsenohauchecornite in various rocks and ores. With the increase in crustal material contamination, it can reach arsenide saturation locally in sulfide melt, then a separate Ni-rich arsenide (bismuth) melt exsolves somewhere. This melt will crystallize into nickeline, parkerite, arsenohauchecornite, and maucherite first. Second, most of nickel and cobalt tend to enter cobaltite and pentlandite phases, rather than existing in chalcopyrite and pyrrhotite phases as isomorphism during sufficient fractional crystallization of sulfide melt, which gathered nickel and cobalt elements widely. Also, more than one magma might result in the superposition of ore-forming elements. Later, the ore-forming elements redistribute limitedly through a hydrothermal process. The metallogenic mechanism model of nickel and cobalt established in the present study not only explains the process of nickel–cobalt mineralization in Xiarihamu but also can be applied to similar deposits and has a wide universal replicability.
Implementation of Ion Exchange Processes for Carbon Dioxide Mineralization Using Industrial Waste Streams
Authors: Bustillos Steven , Alturki Abdulaziz , Prentice Dale , La Plante Erika Callagon , Rogers Mitchell , Keller Mark , Ragipani Raghavendra , Wang Bu , Sant Gaurav , Simonetti Dante A. 
Published: December 2020

Sequestration of CO2 within stable mineral carbonates (e.g., CaCO3) represents an attractive emission reduction strategy because it offers a leakage-free alternative to geological storage of CO2 in an environmentally benign form. However, the pH of aqueous streams equilibrated with gaseous streams containing CO2 (pH &lt; 4) are typically lower than that which is required for carbonate precipitation (pH &gt; 8). Traditionally, alkalinity is provided by a stoichiometric reagent (e.g., NaOH) which renders these processes environmentally hazardous and economically unfeasible. This work investigates the use of regenerable ion-exchange materials to induce alkalinity in CO2-saturated aqueous solutions such that the pH shift required for mineralization occurs without the need for stoichiometric reagents. Na+-H+ exchange isotherms (at [H+] = 10−8–10−1 M) and rates were measured for 13X and 4A zeolites and TP-207 and TP-260 organic exchange resins in batch equilibrium and fixed-bed exchange experiments, respectively. At solutions equilibrated with CO2 at 1.0 atm (pH = 3.9), H+ exchange capacities for the materials were similar (1.7–2.4 mmol H+/g material) and resulted in pH increases from 3.9 to greater than 8.0. Multi-component mixtures using Ca2+ and Mg2+ cations (at 10−3–10−1 M) in CO2-saturated water were used to probe competitive ion exchange. The presence of divalent cations in solution inhibited H+ exchange, reducing capacities to as low as 0.2 mmol H+/g for both resins and zeolites. Dynamic H+ exchange capacities in fixed-bed ion exchange columns were similar to equilibrium values for resins (∼1.5 mmol/g) and zeolites (∼0.8 mmol/g) using inlet solutions that were equilibrated with gaseous streams of CO2 at 1.0 atm. However, exchange kinetics were limited by intraparticle diffusion as indicated by the increased rate parameters with increasing inlet flow rates (20–160 cm3 min−1). Experimental calcite precipitation from mixing the alkaline CO32−-rich water solution obtained from the ion-exchange column with a simulated liquid waste stream solution achieved thermodynamic maximum yields. The results from these studies indicate that ion exchange processes can be used as an alternative to the addition of stoichiometric bases to induce alkalinity for the precipitation of CaCO3, thereby opening a pathway toward sustainable and economic mineralization processes.
Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species
Authors: Zelek Wioleta M. , Morgan B. Paul 
Published: December 2020

Better understanding of roles of complement in pathology has fuelled an explosion of interest in complement-targeted therapeutics. The C5-blocking monoclonal antibody (mAb) eculizumab, the first of the new wave of complement blocking drugs, was FDA approved for treatment of Paroxysmal Nocturnal Hemoglobinuria in 2007; its expansion into other diseases has been slow and remains restricted to rare and ultra-rare diseases such as atypical hemolytic uremic syndrome. The success of eculizumab has provoked other Pharma to follow this well-trodden track and made C5 blockade the busiest area of complement drug development. C5 blockade inhibits generation of C5a and C5b, the former an anaphylatoxin, the latter the nidus for formation of the pro-inflammatory membrane attack complex. In order to use anti-complement drugs in common complement-driven diseases, more affordable and equally effective therapeutics are needed. To address this, we explored complement inhibition downstream of C5. Novel blocking mAbs targeting C7 and/or the C5b-7 complex were generated, identified using high throughput functional assays and specificity confirmed by immunochemical assays and surface plasmon resonance (SPR). Selected mAbs were tested in rodents to characterize pharmacokinetics, and therapeutic capacity. Administration of a mouse C7-selective mAb to wildtype mice, or a human C7 specific mAb to C7-deficient mice reconstituted with human C7, completely inhibited serum lytic activity for &gt;48 h. The C5b-7 complex selective mAb 2H2, most active in rat serum, efficiently inhibited serum lytic activityin vivofor over a week from a single low dose (10 mg/kg); this mAb effectively blocked disease and protected muscle endplates from destruction in a rat myasthenia model. Targeting C7 and C7-containing terminal pathway intermediates is an innovative therapeutic approach, allowing lower drug dose and lower product cost, that will facilitate the expansion of complement therapeutics to common diseases.
KLHL5 Is a Prognostic-Related Biomarker and Correlated With Immune Infiltrates in Gastric Cancer
Authors: Wu Qiulin , Yin Guobing , Lei Jinwei , Tian Jiao , Lan Ailin , Liu Shengchun 
Published: December 2020

Background: KLHL5 (Kelch Like Family Member 5) is differentially expressed in gastric cancer, but its correlation with prognosis and functioning mechanism in gastric cancer remain unclear.Methods: The Oncomine database and TIMER were employed to appraise the KLHL5 expression in a variety of cancers. The correlation between KLHL5 expression and patient prognosis was extracted from the Kaplan–Meier plotter, GEPIA, and PrognoScan database. Then the relationship between KLHL5 expression and inflammatory infiltrate profiles was inquired by TIMER. Finally, GEPIA and TIMER were explored for the correlative significance between KLHL5 expression and immune cell–related marker sets.Results: KLHL5 was found to be differentially expressed and correlated with clinical outcomes in several types of cancers in the TCGA database. Especially, KLHL5 mRNA expression was upregulated and correlated with poorer overall survival and progression-free survival in gastric cancer. Moreover, elevated KLHL5 expression was significantly related with patient node stage, infiltration level, and expression of multiple immune marker sets.Conclusions: These results implicate that KLHL5 expression is closely linked with patient clinical outcomes and the microenvironmental infiltration level in different neoplasms. This indicates that KLHL5 is a modulator in infiltrate recruitment, shaping the landscape of immune cell infiltration. Thus, it represents an eligible prognostic predictor for gastric malignancy.
Changes in Prefrontal Cortical Activity During Walking and Cognitive Functions Among Patients With Parkinson's Disease
Authors: Ranchet Maud , Hoang Isabelle , Cheminon Maxime , Derollepot Romain , Devos Hannes , Perrey Stephane , Luauté Jacques , Danaila Teodor , Paire-Ficout Laurence 
Published: December 2020

Background: Walking becomes more and more degraded as Parkinson's Disease (PD) progresses. Previous research examined factors contributing to this deterioration. Among them, changes in brain cortical activity during walking have been less studied in this clinical population.Objectives: This study aimed to: (1) investigate changes in dorsolateral prefrontal cortex (DLPFC) activation during usual walking and dual-task walking conditions in patients with PD; (2) examine the association between cortical activity and behavioral/cognitive outcomes; and (3) explore which factors best predict increased activation of the DLPFC during usual walking.Methods: Eighteen patients with early stage PD and 18 controls performed 4 conditions: (1) standing while subtracting, (2) usual walking, (3) walking while counting forward, and (4) walking while subtracting. Cortical activity in DLPFC, assessed by changes in oxy-hemoglobin (ΔHbO2) and deoxy-hemoglobin (ΔHbR), was measured using functional near infrared spectroscopy (fNIRS). Gait performance was recorded using wearables sensors. Cognition was also assessed using neuropsychological tests, including the Trail Making Test (TMT).Results: DLPFC activity was higher in patients compared to controls during both usual walking and walking while subtracting conditions. Patients had impaired walking performance compared to controls only during walking while subtracting task. Moderate-to-strong correlations between ΔHbO2 and coefficients of variation of all gait parameters were found for usual walking and during walking while counting forward conditions. Part-B of TMT predicted 21% of the variance of ΔHbO2 during usual walking after adjustment for group status.Conclusions: The increased DLPFC activity in patients during usual walking suggests a potential compensation for executive deficits. Understanding changes in DLPFC activity during walking may have implications for rehabilitation of gait in patients with PD.