bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender-Difference in the Association Between Anthropometric Parameters and the Risk Factors of Cardiovascular Diseases in Rural Chinese People: The Handan Eye Study
Authors: Liu Juping , Hao Jie , Cao Kai , Zhang Ye , Liang Yuanbo , Li Sizhen , Peng Xiaoxia , Li Xiaorong , Wang Ningli 
Published: June 2020

Abstract
Background

Body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), waist/hip/height ratio (WHHR), sagittal abdominal diameter (SAD), and SAD/height ratio (SADHR) are all anthropometric tools used to categorize obesity status. This study aimed to determine associations between different anthropometric indices and the risk of cardiovascular disease (CVD) in Chinese rural areas.
Methods

The Handan Eye Study is a population-based, longitudinal study. In total, 6830 participants, aged 30 years or older, participated in the baseline study (HES-1). Among them, 5394 subjects of the 6323 survivors (follow-up rate: 85.3%) took part in the 6-year follow-up study (HES-2). As a new anthropometric parameter, SAD was added into HES-2. Meanwhile total cholesterol, high-density lipoprotein protein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and other biochemical data were recorded. This cross-sectional study analyzed these anthropometric obesity indices and correlations with CVD. Prevalence of metabolic syndrome (MS) was used as the indicator of CVD.
Results

Among the 5394 patients in this study, multivariate analysis revealed higher BMI and WC in women compared to men (24.61 vs. 23.66, p < 0.0001). SAD, WHR, and WHHR showed a smaller correlation to CVD risk factors when compared with other anthropometric parameters. WC and SADHR were more effective predictors of CVD and MS. In men, BMI exhibited a greater proportionality to high-TG (0.693) and hypertension (0.593) and SADHR showed a correlation to low-HDL (0.561) as well as high-glucose (0.664). WC and SADHR were the most effective diagnostic parameters in women.
Conclusions

Within a rural Chinese population, women were observed to be comparatively more overweight than men. SADHR and BMI serve as effective indicators of CVD and MS in men, whereas SADHR and WC are more effective indicators of CVD and MS in women. Age and gender affect anthropometric obesity indices and correlations with CVD.
Robot-Assisted Retroperitoneal Lymphadenectomy In A Patient With Type I Papillary Renal Cancer Recurrence After Five Years Of Follow-Up: A Case Report.
Authors: SALHI Yazan AL , FUSCHI Andrea , VELOTTI Gennaro , CAPONE Lorenzo , AVERSA Sara , NUNZIO Cosimo DE , PETROZZA Vincenzo , CARBONE Antonio , Pastore Antonio Luigi 
Published: June 2020

Abstract
INTRODUCTION: Papillary renal cell carcinoma is a rare cancer and is the second most frequent histologic type among all renal cell carcinoma, accounting for up to 15%. Patients with type 1 PRCC are diagnosed at a lower stage and present a lower nuclear grade compared to type 2.CASE PRESENTATION: A 72-year-old man underwent a right radical nephrectomy 7 years ago for a 10 cm mesorenal mass with a final histopathological diagnosis of a papillary renal cell carcinoma type 1 pT2a with negative surgical margins.Five years after the surgery, computed tomography (CT) scan imaging showed the presence of multiple masses suspicious for node recurrences disease localized in the renal lodge, in the inter-aorto-caval space, at the iliac vessel bifurcation and right common iliac vessels. Patient underwent a robotic retroperitoneal lymphadenectomy. The operative time was 114 min, estimated blood loss 200 ml; length of hospital stay 4 days. The abdominal drainage was removed at first post-operative day. No perioperative complications. The removed lesions confirmed on histopathological examination the recurrence of type I papillary renal cancer at: renal lodge, inter-aorto-caval space, iliac bifurcation, common iliac lymph nodes. No further recurrences on surveillance imaging 24 months after his procedure.DISCUSSION AND CONCLUSION: We present the first description of minimally invasive surgical excision for a papillary type I renal cancer nodal recurrence and renal fossa recurrence.Our present study shows that patients treated with surgical excision for isolated RPLN recurrences may afford select patient durable cancer control.The robotic approach can be offered as an effective modality of treatment in this rare case of type I papillary renal cancer metastases.The extent of resection, as well as the optimal integration of surgery and systemic therapy, remain to be determined in this setting.
The Relationship Between Different Types of Caries and Periodontal Disease Severity in Middle-Aged and Elderly People: Findings from the 4th National Oral Health Survey of China
Authors: Yu Lixia , WANG Xing , FENG Xi Ping , TAI Bao Jun , HU De Yu , WANG Bo , WANG Chun Xiao , ZHENG Shu Guo , LIU Xue Nan , RONG Wen Sheng , WANG Wei Jian , SI Yan , Lin Huan Cai 
Published: June 2020

Abstract
Background: To explore the relationship between different types of caries and periodontal disease severity in middle-aged and elderly people in China. Methods: The study population consisted of 4,387 middle-aged and 3,225 elderly subjects. Caries was divided into three types: type A, crown caries; type B, lesions involving both the crown and root, which represents mixed type; and type C, root caries. These three types together represent the overall caries situation, which we call type ABC. Caries was quantitated by decayed and filled teeth (DFT index). Periodontitis was evaluated by clinical attachment loss.Results: Middle-aged people with periodontitis had a significant association with DFT of type ABC (OR: 1.09, 95% CI: 1.06‐1.11), type A (OR: 1.05, 95% CI: 1.02‐1.08), type B (OR: 1.20, 95% CI: 1.16-1.28) and type C (OR: 1.36, 95% CI: 1.15-1.60). Elderly people with periodontitis had a significant association with DFT of type ABC (OR: 1.05, 95% CI: 1.03-1.07), type B (OR: 1.07, 95% CI: 1.05-1.10) and type C (OR: 1.30, 95% CI: 1.19-1.42)，but not with type A.Conclusions: Different types of caries in middle-aged people, the overall caries and caries types involving the root surface in elderly people were significantly associated with periodontal disease severity.
Evaluation of Efficacy and Safety of Percutaneous Transforaminal Endoscopic Surgery (PTES) for Surgical Treatment of Calcified Lumbar Disc Herniation: A Retrospective Cohort Study of 101 Patients
Authors: Wang Hao , Zhou Tianyao , Gu Yutong , Yan Zuoqin 
Published: June 2020

Abstract
Purpose: Percutaneous transforaminal endoscopy has been widely used to treat lumbar disc herniation, but the steep learning curve and difficulties in removing the calcified disc hinders the application of conventional endoscopy in treating calcified lumbar disc herniation. In 2017, we first reported Percutaneous Transforaminal Endoscopic Surgery (PTES) as an easy-to-learn posterolateral transforaminal endoscopic technique to decompress the nerve root for lumbar disc herniation. We used our PTES technique to remove the calcified lumbar disc herniation and the purpose of this study is to evaluate the safety and efficacy of this technique.Methods: Forty-six patients with calcified lumbar disc herniation (CLDH) and fifty-five patients with uncalcified lumbar disc herniation (ULDH) underwent PTES surgery to decompress the nerve root. Visual analogue scale was collected before the surgery, immediately, one week, one month, two months, three months, six months, 12 months and 24 months after surgery. The outcomes of MacNab classification were collected 24 months after surgery. Intra- and Post-operative complications were also recorded.Results: For CLDH patients, the VAS score was 9 (5-10) before operation, and then dropped to 2 (1-4) after surgery. VAS score continually decreased to 0 (0-3) at 24 months after surgery. 95.65% of CLDH patients showed excellent or good outcomes. ULDH group showed similar MacNab classification (94.55%) and VAS changing curve. The therapeutic effect of PTES in treating calcified lumbar disc herniation was as good as that in treating uncalcified patients.Conclusion: PTES is an effective and safe method to treat calcified lumbar disc herniation.
A MiRNA-based Signature is Associated With Tumor Mutational Burden in Colon Adenocarcinoma
Authors: xue Weijie , Wang Yixiu , Gong Zhiqi , Yang Chenyu , Xie Yuwei , Guan Chunyang , Wei Chuqing , Niu Zhaojian , Zhu Chengzhan 
Published: June 2020

Abstract
Background:Tumor mutation burden (TMB) has become an independent biomarker for predicting the response of Immune checkpoint inhibitors.MiRNA plays an important role in cancer-related immune regulation but the relationship between expression of miRNA and TMB is unclear in colon adenocarcinoma (COAD).Method:The transcriptome profiling data, clinical data, mutation annotation data and miRNA expression profiles for cases with COAD were downloaded from TCGA database, and then COAD samples were randomly divided into training set and test set. The differential expression miRNAs of high and low TMB group in training set was obtained as a signature by the least absolute shrinkage and selection operator (LASSO) logistic regression, and it was verified in test set. UsingLASSO method, principal component analysis (PCA) and ROC to verify the credibility of signature.In addition, the correlation betweenthemiRNA-based signature and immune checkpoints was performed.In the end, enrichment analysis of the miRNAs in signature was performed to explore the biological function.Results:18 differential expression miRNAswere obtainedaccording to LASSO method. According to LASSO method, principal component analysis (PCA) and ROC, we found that the credibility of signature, and the signature can discriminate the high and low TMB level. Furthermore, the results of correlation between the 18-miRNA-based signature and immune checkpoints showed that the miRNA-based model has a strong positive correlation with TMB, weak positive correlation with CTLA4 and CD274 (PD-L1). However, there is no correlation between the model and SNCA (PD-1).Finally, enrichment analysis of the 18miRNAs demonstrated that the 18 miRNAs were involved in process of immunity and cancer pathways.Conclusion:We established a novel miRNA-based signature integrating expression of miRNAs and TMB levels. The 18-miRNA-based signature can effectively predict and discriminate the TMB levels in COAD, and provides apotential guide of ICIs treatment.
Teaching And Learning In A Time Of Corona: A Social Work Experience
Authors: Berger Roni 
Published: June 2020

Abstract
Preliminary results of a qualitative study of the lived experience of teaching and learning during the Covid-19 pandemic are presented. An instructor, a program director and five doctoral students in different stages of their coursework and dissertation proposal development, wrote a reflective journal. Participants varied in their levels of familiarity with technology-assisted education, personal backgrounds and circumstances including work, family and caring for sick relatives responsibilities. Participants’ journals documenting their reactions, struggles and coping since the abrupt move of the university from face to face to online classes were content analyzed. The analysis was co-conducted by all participants to identify themes and generate understanding of the experience. Two main themes emerged from the analysis: A developmental process of participants’ reactions, perceptions and meaning making of the experience and factors that shaped it. Lessons learned are discussed and recommendations for professional education and directions for future research are suggested.
Texture Analysis in the Evaluation of Covid-19 Pneumonia in Chest X-Ray Images: a Proof of Concept Study
Authors: Cavallo Armando Ugo , Troisi Jacopo , Forcina Marco , Mari Piervalerio , Forte Valerio , Sperandio Massimiliano , Pagano Sergio , Cavallo Pierpaolo , Floris Roberto , Garaci Francesco 
Published: June 2020

Abstract
Objectives: One of the most challenging aspects related to Covid-19 is to establish the presence of infection in early phase of the disease. Recently Artificial Intelligence systems for the diagnosis of Covid-19 related pneumonia on Chest X ray (CXR) or chest CT have been tested with variable, but not negligible, accuracy. Texture analysis might be an additional tool for the evaluation of CXR in patients with clinical suspicion of Covid-19 related pneumonia.Methods: CXR images were accessed from a publicly available repository (https://www.kaggle.com/tawsifurrahman/covid19-radiography-database). Lung areas were manually segmented using a polygonal regions of interest (ROI) covering both lung areas, using MaZda, a freely available software for texture analysis. A total of 308 features per ROI was extracted. One hundred-ten Covid-19 CXR images were selected for the final analysisResults: Six models, namely NB, GLM, DL, GBT, ANN and PLS-DA were selected and ensembled. According to Youden’s index, the Covid-19 Ensemble Machine Learning (EML)-Score showing the highest AUCROC (0.971±0.015) was 132.57. Assuming this cut-off the EML model performance was estimated evaluating both true and false positive/negative, resulting in 91.8% accuracy with 93% sensitivity and 90% specificity. Moving the cut-off value to -100, although the accuracy resulted lower (90.6%), the EML showed 100% sensitivity, with 80% specificityConclusion: Texture analysis of CXR images and machine learning algorithms may help in differentiating patients with Covid-19 pneumonia. Despite several limitations, this study can lay ground for future researches in this field and help developing more rapid and accurate screening tools for these patients.
Coronavirus Disease (COVID-19) and the Liver: A comprehensive systematic review and meta-analysis
Authors: Kumar-M Praveen , Mishra Shubhra , Jha Daya Krishna , Shukla Jayendra , Choudhury Arup , Mohindra Ritin , Mandavdhare Harshal S , Dutta Usha , Sharma Vishal 
Published: June 2020

Abstract
Background: Liver function derangements have been reported in coronavirus disease (COVID-19) but reported rates are variable. Methods: We searched Pubmed and Embase with terms COVID and SARS-COV-2 from December 1, 2019 till April 5, 2020. We estimated overall prevalence, stratified prevalence based on severity, estimated risk ratio (RR) and estimated standardized mean difference (SMD) of liver function parameters in severe as compared to nonsevere COVID. Random effect method utilizing inverse variance approach was used for pooling the data. Results: In all, 128 studies were included. The most frequent abnormalities were hypoalbuminemia [61.27% (48.24 - 72.87)], elevations of gamma-glutamyl transferase (GGT) [27.94%(18.22 -40.27)], alanine aminotransferase (ALT) [23.28%(19.92 - 27.01)] and aspartate aminotransferase (AST) [23.41%(18.84 - 28.70)]. Further the relative risk of these abnormalities was higher in the patients with severe COVID-19 when compared to non-severe disease [Hypoalbuminemia - 2.65(1.38 - 5.07); GGT - 2.31(1.6 - 3.33); ALT - 1.76(1.44 - 2.15); AST 2.30(1.82 - 2.90)]. The SMD of hypoalbuminemia, GGT, ALT and AST elevation in severe as compared to nonsevere were -1.05(-1.27 - -0.83), 0.76(0.40 - 1.12), 0.42(0.27 - 0.56) and 0.69 (0.52 - 0.86) respectively. The pooled prevalence and RR of chronic liver disease as a comorbidity was 2.64% (1.73- 4) and 1.69(1.05-2.73) respectively. Conclusion: The most frequent abnormality in liver functions was hypoalbuminemia followed by derangements in gamma-glutamyl transferase and aminotransferases and these abnormalities were more frequent in severe disease. The systematic review was, however, limited by heterogeneity in definitions of severity and liver function derangements.
PCDHB17P/miR-145-3p/MELK/NF-κB Feedback Loop Promotes Metastasis and Angiogenesis of Breast Cancer​
Authors: Zhu Li , Zhang Yanjun , Wang Bin , Yang Li , Zheng Yiqiong , Sun Linde , Tian Lin , Wang Jian-Dong , Chen Tao 
Published: June 2020

Abstract
Background: Breast cancer is one of the most common life-threatening cancers, mainly due to its aggressiveness and metastasis. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) participate in the development and progression of breast cancer. Nevertheless, the function and expression level of lncRNAs in breast cancer are still not fully understood.Methods: TCGA data was utilized to screen out lncRNAs dysregulated in breast cancer. The expression level of genes were analyzed and measured by RT-qPCR. The effects of PCDHB17P in breast cancer were determined in vitro and in vivo. Bioinformatics analysis was applied to predict the target between genes in breast cancer and verified via luciferase reporter assays, RNA Immunoprecipitation (RIP) and Chromatin immunoprecipitation (ChIP).Results: LncRNA PCDHB17P was up-expressed in human breast cancer tissues and cell lines. Knockdown of PCDHB17P remarkably suppressed migration and invasion as well as tube formation ability of breast cancer cells. MiR-145-3p was significantly decree ased in breast cancer samples, which was negatively correlated to the expression of PCDHB17P. In addition, we identified MELK was a direct target gene of miR-145-3p, which was higher expressed in breast cancer tissues than that in adjacent normal tissues. Mechanistic investigation indicated that PCDHB17P acted as a cancer-promoting competing endogenous RNA (ceRNA) by binding miR-145-3p and upregulating MELK. Interestingly, MELK could in turn increase the promoter activity and expression of PCDHB17P via NF-κB, thus forming a positive feedback loop that drives the metastasis and angiogenesis of breast cancer.Conclusions: Our research demonstrated that the constitutive activation of PCDHB17P/miR-145-3p/MELK /NF-κB feedback loop promotes the metastasis and angiogenesis of breast cancer, suggested that this lncRNA might be a promising prognostic biomarker and therapeutic target for breast cancer.
Cumulative live birth rate and cost-effectiveness analysis between GnRH-antagonist protocol and multiple minimal ovarian stimulation in poor responder
Authors: Liu Yuan , Wu Yu 
Published: June 2020

Abstract
Background

The overall cumulative live birth rate (CLBR) of poor ovary responders (POR) is extremely low. Minimal ovarian stimulation (MOS) suggested a relative realistic solution in ART for POR. Our study aimed to investigate whether multiple MOS strategy results in higher CLBR compared to GnRH antagonist protocol and the cost-effectiveness analysis in POR.
Methods

This retrospective study involved 699 patients (1058 cycles) who fulfilled the Bologna criteria in one center performed from 2010–2018. Specifically, 325 women (325 cycles) were treated with one time conventional GnRH antagonist ovarian stimulation (GnRH-antagonist). Another 374 patients (733 cycles) were treated with multiple minimal ovarian stimulations (MOS) including natural cycles. CLBR and cost-effectiveness analysis were performed comparing these two groups of women.
Results

GnRH- antagonist leads to more oocytes retrieved, more fertilized oocytes and more viable embryos compared to first MOS (p < 0.001) and the cumulative corresponding ones in multiple MOS (p < 0.001). For the first IVF cycle, GnRH- antagonist results in higher CLBR than MOS (12.92% versus 4.54%, Adjusted OR 2.606; 95%CI 1.386, 4.899, p = 0.003). However, GnRH-antagonist induces comparable CLBR with multiple MOS (12.92% versus 7.92%, Adjusted OR 1.702; 95%CI 0.971, 2.982, p = 0.063), but absolutely shorter time to live birth (9 (8, 10.75) months versus 11 (9, 14) months, p = 0.014) and similar financial expenditure compared to repeated MOS (20838 (17953, 23422) ¥ versus 21261.5 (15892.5, 35140.25) ¥, p = 0.13).
Conclusion

Both MOS and GnRH-antagonist provide low chance of live birth for poor responders. GnRH antagonist protocol is a sound choice for POR with comparable CLBR, shorter time to live birth and similar financial expenditure.
Impact of Racism and Discrimination on The Physical and Mental Health Among Aboriginal and Torres Strait Islander Peoples Living in Australia: A Protocol For A Scoping Review
Authors: Kairuz Camila A , Casanelia Lisa M , Bennett-Brook Keziah , Coombes Julieann , Yadav Uday Narayan 
Published: June 2020

Abstract
Background: Racism is increasingly recognised internationally as a key factor contributing to health disparities. A comprehensive body of strong research from international authors has reported negative associations between racism and health outcomes. In Australia, although the literature is more limited, available findings follow global trends. Australia has an identified health gap between Aboriginal and Torres Strait Islander peoples and non-Indigenous Australians, and despite efforts to bridge this gap, health inequities continue to exist. This scoping review aims to assess, analyse and synthesise the relationship between racism and discrimination on the physical and mental health of Aboriginal and Torres Strait Islander peoples living in Australia.Method: This is the study protocol for a scoping review. A systematic search will be conducted using five electronic databases: PubMed, CINAHL, Embase, Web of Science and the Australia’s National Institute for Aboriginal and Torres Strait Islander Health Research. The database search will include studies published between 2000 and 2020. Reference lists of the included articles will be searched. Outcome measures will include physical and mental health components including chronic conditions, depression and anxiety, psychological distress, social and emotional difficulties, suicide and health-related outcomes such as wellbeing and life satisfaction. Duplications will be removed, and titles and abstracts will be reviewed to select studies. Full-text screening of preselected studies will be performed by four reviewers independently, to select studies according to inclusion criteria. Included studies will be appraised for quality using appropriate tools tailored for each study design. Data will be extracted, and study findings and characteristics synthesised in a narrative summary. Discussion: Our scoping review will synthesise the evidence on the impacts of racism and discrimination in relation to the physical and mental health of Aboriginal and Torres Strait Islander peoples living in Australia. These findings could guide future health interventions by addressing the exposure of racism and racial discrimination in order to reduce health disparity. It is anticipated the findings to be of interest to policymakers, researchers, Aboriginal and Torres Strait Islander communities and community health organisations and other stakeholders interested in optimising public health interventions for and in partnership with Aboriginal and Strait Torres Islander communities of Australia. Systematic review registration: The protocol for this review has been registered on the International prospective register of systematic reviews (PROSPERO), and a registration number has not been provided yet.