bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of core-based exercise in people with scoliosis: A systematic review and meta-analysis
Authors: Li Xin , Shen Jie , Liang Juping , Zhou Xuan , Yang Yuqi , Wang Dexuan , Wang Shanshan , Wang Lixia , Wang Hong , Du Qing 
Published: December 2020

Objective: To systematically assess the effectiveness of core-based exercise for correcting a spinal deformity and improving quality of life in people with scoliosis. Data sources: The PubMed, Embase, Cochrane Library, Cumulative Index of Nursing and Allied Health Literature (CINAHL), and Web of Science databases were searched from inception up to September 30, 2020. Methods: Clinical controlled trials were eligible if they compared the effectiveness of core-based exercise to other nonsurgical interventions in people with scoliosis. The revised Cochrane risk of bias assessment tool for randomized trials and the methodological index for non-randomized studies scale were used to assess the risk of bias. The outcomes included the Cobb angle, the angle of trunk rotation and quality of life. RevMan 5.3 was used, and intergroup differences were determined by calculating mean differences (MD) and 95% confidence intervals (CIs). Results: After screening 1348 studies, nine studies with 325 participants met the inclusion criteria. The exercise group had significantly lower Cobb angles (MD = −2.08, 95% CI: −3.89 to −0.28, P = 0.02) and significantly better quality of life as measured by the Scoliosis Research Society-22 questionnaire (MD = 0.25, 95% CI: 0.02 to 0.49, P = 0.03) than the control groups. However, no significant difference was observed regarding the angle of trunk rotation between groups (MD = −0.69, 95% CI: −2.61 to 1.22, P = 0.48). Furthermore, no serious adverse events were reported. The overall quality of evidence ranged from low to very low. Conclusion: Core-based exercise may have a beneficial role in reducing the Cobb angle and improving quality of life in people with scoliosis in the short term. PROSPERO registration number: CRD42020160509 (Available at http://www.crd.york.ac.uk/prospero/ )
Rehabilitation following rotator cuff repair: A nested qualitative study exploring the perceptions and experiences of participants in a randomised controlled trial
Authors: Stephens Gareth , Littlewood Chris , Foster Nadine E , Dikomitis Lisa 
Published: December 2020

Objective: To investigate acceptability, barriers to adherence with the interventions, and which outcome measures best reflect the participants’ rehabilitation goals in a pilot and feasibility randomised controlled trial evaluating early patient-directed rehabilitation and standard rehabilitation, including sling immobilisation for four weeks, following surgical repair of the rotator cuff of the shoulder. Design: Nested qualitative study. Setting: Five English National Health Service Hospitals. Subjects: Nineteen patient participants who had undergone surgical repair of the rotator cuff and 10 healthcare practitioners involved in the trial. Method: Individual semi-structured interviews. Data were analysed thematically. Results: Four themes: (1) Preconceptions of early mobilisation; many participants were motivated to enter the trial for the opportunity of removing their sling and getting moving early. (2) Sling use and movement restrictions; for some, sling use for four weeks was unacceptable and contributed to their pain, rather than relieving it. (3) Tensions associated with early mobilisation; clinical tensions regarding early mobilisation and the perceived risk to the surgical repair were apparent. (4) Processes of running the trial; participants found the trial processes to be largely appropriate and acceptable, but withholding the results of the post-operative research ultrasound scan was contentious. Conclusion: Trial processes were largely acceptable, except for withholding results of the ultrasound scan. For some participants, use of the shoulder sling for a prolonged period after surgery was a reported barrier to standard rehabilitation whereas the concept of early mobilisation contributed tension for some healthcare practitioners due to concern about the effect on the surgical repair.
Effect of combined home-based, overground robotic-assisted gait training and usual physiotherapy on clinical functional outcomes in people with chronic stroke: A randomized controlled trial
Authors: Wright Amy , Stone Keeron , Martinelli Louis , Fryer Simon , Smith Grace , Lambrick Danielle , Stoner Lee , Jobson Simon , Faulkner James 
Published: December 2020

Objectives: To assess the effect of a home-based over-ground robotic-assisted gait training program using the AlterG Bionic Leg orthosis on clinical functional outcomes in people with chronic stroke. Design: Randomized controlled trial. Setting: Home. Participants: Thirty-four ambulatory chronic stroke patients who recieve usual physiotherapy. Intervention: Usual physiotherapy plus either (1)10-week over-ground robotic-assisted gait training program ( n = 16), using the device for ⩾30 minutes per day, or (2) control group ( n = 18), 30 minutes of physical activity per day. Measurements: The primary outcome was the Six-Minute Walk Test. Secondary outcomes included: Timed-Up-and-Go, Functional Ambulation Categories, Dynamic Gait Index and Berg Balance Scale. Physical activity and sedentary time were assessed using accelerometry. All measurements were completed at baseline, 10 and 22 weeks after baseline. Results: Significant increases in walking distance were observed for the Six-Minute Walk Test between baseline and 10 weeks for over-ground robotic-assisted gait training (135 ± 81 m vs 158 ± 93 m, respectively; P ⩽ 0.001) but not for control (122 ± 92 m vs 119 ± 84 m, respectively). Findings were similar for Functional Ambulation Categories, Dynamic Gait Index and Berg Balance Scale (all P ⩽ 0.01). For over-ground robotic-assisted gait training, there were increases in time spent stepping, number of steps taken, number of sit-to-stand transitions, and reductions in time spent sitting/supine between baseline and 10 weeks (all P < 0.05). The differences observed in all of the aforementioned outcome measures were maintained at 22 weeks, 12 weeks after completing the intervention (all P > 0.05). Conclusion: Over-ground robotic-assisted gait training combined with physiotherapy in chronic stroke patients led to significant improvements in clinical functional outcomes and physical activity compared to the control group. Improvements were maintained at 22 weeks.
Bing-Neel syndrome: A case reports
Authors: Demircioğlu Sinan , Oltulu Pembe , Emlik Ganime D , Tekinalp Atakan , Çeneli Özcan 
Published: December 2020

Introduction Bing-Neel syndrome (BNS) is a rare complication of of Waldenström macroglobulinemia (WM) identified by involvement of central nervous system (CNS) lymphoplasmacytic cells. Case report We present a patient who was diagnosed with Bing-Neel syndrome four years after the diagnosis of Waldenström macroglobulinemia. Management & outcome The patient was admitted with neurological symptoms. There were lesions associated with WM involvement on brain imaging. The diagnosis was made by brain biopsy. High dose methotrexate treatment was given. Discussion CNS infiltrating agents such as fludarabine, methotrexate and cytarabine are often used in BNS treatment. Ibrutinib, which is a new bruton tyrosine kinase inhibitor, has recently started to be used in BNS treatment, as it has been shown to be effective and penetrate the CNS.
5,10-methylenetetrahydrofolate reductase C677T gene polymorphism and peripheral arterial disease: A meta-analysis
Authors: Liu Fanyun , Du Jun , Nie Menglin , Fu Jian , Sun Jianming 
Published: December 2020

Introduction Peripheral arterial disease is one common vascular disease most caused by atherosclerosis. As with stroke and coronary heart disease, peripheral arterial disease is one clinical type of atherosclerotic cardiovascular disease with many unmeasured environmental and genetic components. MTHFR C677T polymorphism is associated with the increased risk of ischemic stroke and coronary heart disease. MTHFR C677T polymorphism is associated with decreasing enzyme activity and increasing homocysteine levels. Meta-analysis of studies had demonstrated an association between elevated plasma homocysteine levels and peripheral arterial disease. Elevated plasma homocysteine level is closely related to MTHFR C677T polymorphism. Recent studies had clarified the relationship of MTHFR C677T polymorphism and peripheral arterial disease. So we performed a meta-analysis to investigate the association between MTHFR C677T polymorphism and peripheral arterial disease. Materials and methods We searched the database PubMed, Embase, and Cochrane Library for all English-language articles related to peripheral arterial disease and MTHFR C677T through 30 June 2020. Analysis results were shown by forest plot. Publication bias was estimated using funnel plot. Results A total of 15 studies comprising 1929 patients with peripheral arterial disease and 2952 healthy controls were included in the meta-analysis. Significant associations between MTHFR C677T genetic polymorphism and peripheral arterial disease were found (OR = 1.31, 95% CI: 1.09–1.58, P <0.01). But there was no significant association (poor OR = 1.11, 95% CI: 0.98–1.26, P =0.11) between the T allele carrier and peripheral arterial disease. Conclusion Our meta-analysis suggested that MTHFR C677T genetic polymorphism TT genotype may be associated with increased peripheral arterial disease risk. But further studies with large sample sizes are needed to confirm our findings.
Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19
Authors: Argañaraz Gustavo A. , Palmeira Julys da Fonseca , Argañaraz Enrique R. 
Published: December 2020

AbstractThe rapid ability of SARS-CoV-2 to spread among humans, along with the clinical complications of coronavirus disease 2019—COVID-19, have represented a significant challenge to the health management systems worldwide. The acute inflammation and coagulation abnormalities appear as the main causes for thousands of deaths worldwide. The intense inflammatory response could be involved with the formation of thrombi. For instance, the presence of uncleaved large multimers of von Willebrand (vWF), due to low ADAMTS13 activity in plasma could be explained by the inhibitory action of pro-inflammatory molecules such as IL-1β and C reactive protein. In addition, the damage to endothelial cells after viral infection and/or activation of endothelium by pro-inflammatory cytokines, such as IL-1β, IL-6, IFN-γ, IL-8, and TNF-α induces platelets and monocyte aggregation in the vascular wall and expression of tissue factor (TF). The TF expression may culminate in the formation of thrombi, and activation of cascade by the extrinsic pathway by association with factor VII. In this scenario, the phosphatidylserine—PtdSer exposure on the outer leaflet of the cell membrane as consequence of viral infection emerges as another possible underlying mechanism to acute immune inflammatory response and activation of coagulation cascade. The PtdSer exposure may be an important mechanism related to ADAM17—mediated ACE2, TNF-α, EGFR and IL-6R shedding, and the activation of TF on the surface of infected endothelial cells. In this review, we address the underlying mechanisms involved in the pathophysiology of inflammation and coagulation abnormalities. Moreover, we introduce key biochemical and pathophysiological concepts that support the possible participation of PtdSer exposure on the outer side of the SARS-CoV-2 infected cells membrane, in the pathophysiology of COVID-19.
Pain as clinical manifestations of COVID-19 infection and its management in the pandemic era: a literature review
Authors: Widyadharma I. Putu Eka , Sari Ni Nyoman Shinta Prasista , Pradnyaswari Kadek Enny , Yuwana Kadek Tresna , Adikarya I. Putu Gede Danika , Tertia Clarissa , Wijayanti I. A. Sri , Indrayani I. A. Sri , Utami Desak Ketut Indrasari 
Published: December 2020

AbstractCoronavirus disease 2019 (COVID-19) is a current global pandemic. The case number has increased since December 31, 2019. It has been reported that COVID-19 patients have been giving pain complaints, one of which is muscular pain. Other types of pain that have also been reported by COVID-19 patients are joint pain, stomach pain, and testicular pain. Neuropathic pain is the rarest case among others. COVID-19 mechanisms in the nerve and musculoskeletal damage are believed to be caused by the expression and distribution of angiotensin-converting enzyme 2 (ACE-2). Patients with pain, especially neuropathic pain, normally do not respond well to various therapies, and experience psychiatric disorders such as depression, which leads to a decrease in the patient’s quality of life. Important considerations for health professionals in terms of pain management during this pandemic include ensuring treatment continuity, painkillers, utilization of telemedicine, biopsychosocial management approach, and modifying therapy needs to reduce the risks of COVID-19 complications.
ЭКОЛОГО-ХИМИЧЕСКАЯ ОЦЕНКА РОДНИКОВ ГОРОДСКИХ И СЕЛЬСКИХ ПОСЕЛЕНИЙ НЕЧЕРНОЗЕМЬЯ РФ ПО ДАННЫМ МОНИТОРИНГА (БРЯНСКАЯ ОБЛАСТЬ, 2012–2020 ГГ.)
Authors: Soboleva Olga Alexandrovna , Anishchenko Lidiya Nikolaevna , Shchetinskaya Olga Stefanovna , Dolganova Marina Vladimirovna , Demichov Vladimir Tichonovach 
Published: December 2020

Гидрохимические мониторинговые исследования обобщают результаты информационной базы эколого-химической оценки родников городских и сельских поселений Нечерноземья РФ (в пределах староосвоенного региона Брянской области) на основе восьмилетних изысканий. Комплексные научные работы по ведению и обновлению экомониторинговой базы родников городских и сельских поселений Брянской области реализуются с 2012 года для разработки и реализации программ их оптимизации. За период ведения мониторинговых наблюдений для информационной базы закартированы 248 родников с сопутствующими эколого-аналитическими данными состояния вод: 64 – на территории городских поселений, 182 – на территории сельских поселений. Каждый из отобранных образцов воды был проанализирован по 13 показателям эколого-аналитического качества по аттестованным методикам.Мониторинговые исследования показали, что основные загрязняющие компоненты родниковых вод поселений Брянской области – нитрат-ионы, соли кальция и магния, общее содержание железа. За период наблюдений зарегистрировано значительное изменение химического состава родниковых вод в сторону повышения содержания загрязняющих компонентов на территории малых урбоэкосистем в Брянской области. Основные причины изменения качества вод – антропогенный фактор, падение уровня подземных вод, сброс в водные объекты загрязненных промышленных и коммунальных стоков, интенсивное использование земель в сельскохозяйственном производстве. Рекомендовано ведение постоянного мониторинга гидрохимических показателей городских родников, особенно по химически значимым индикаторным показателям: содержанию нитрат-ионов, общей жёсткости, содержанию железа общего. Результаты данной статьи будут использованы для дополнения мониторинговой базы, реализуемой в Атласе родников Брянской области.
ИЗМЕНЧИВОСТЬ МОРФОЛОГИЧЕСКОЙ СТРУКТУРЫ РАСТЕНИЙ В ЦЕНОПОПУЛЯЦИЯХ TULIPA BIEBERSTEINIANA SCHULT. ET SCHULT. (LILIACEAE) В УСЛОВИЯХ КАЛМЫКИИ
Authors: Anzhaev Nikolay Olegovizh , Borlykov Savr Hongorovyzh , Ovadykova Zhanna Vasilevna , Lidzhieva Nina Tserenovna 
Published: December 2020

В статье приведены данные по изучению изменчивости морфологической структуры растений в популяциях Tulipa biеbersteiniana Schult. et Schult. (Liliaceae), произраставщих в пределах двух крупных геоморфологических структур Республики Калмыкия – Прикаспийской низменности и Долине Маныча. В Долине Маныча видовая популяция № 1 произрастала в составе разнотравно-злакового (Poaceae-Mixteherbosa) сообщества и ценопопуляцию № 2 в составе разнотравно-типчаково-полынкового (Artemisia austriaca-Festuca valesiaca-Mixteherbosa) сообщества, произрастающих на лугово-каштановых почвах. В Прикаспийской низменности видовая популяция № 3 входила в состав эфемерово-луковичномятликового (Poa bulbosa-Ephemerosa) сообщества; ценопопуляцию № 4 в состав эфемерово-луковичномятликово-лерхополынное (Artemisia lercheana-Poa bulbosa-Ephemerosa) сообщества, которые произрастают бурых пустынно-степных солонцеватых почвах.Растения из ценопопуляций T. biеbersteiniana, произрастающих в Долине Маныча, имели большие значения признаков, чем ценопопуляции с Прикаспийской низменности. В ценопопуляциях T. biеbersteiniana наибольшее значение всех признаков растений отмечали в 2017 году, наименьшее – в 2016 году, что свидетельствует о более благоприятных для роста и развития растений погодных условиях в этот год.В ценопопуляциях T. biеbersteiniana девять морфологических признаков, характеризующих вегетативную и генеративную сферу растений варьрировали в 2016 на высоком и среднем уровнях изменчивости, в 2017 году – преимущественно на высоком уровне изменчивости.
Kompetencje miękkie tłumacza w ujęciu interdyscyplinarnym
Authors: Kruk-Junger Katarzyna 
Published: December 2020

Soft Skills in Translation: An Interdisciplinary Approach
The article reviews the topic of soft skills in Translation Studies, to compare it with the research regarding this issue in other disciplines. An analysis of the competences required by the work market with the tools “borrowed” from Social Sciences helps to demonstrate the discrepancies between the proposals of T.S. regarding translator’s skills and the theories offered by other branches of knowledge, and, perhaps more importantly, the opinions about the desired qualifications professed by the potential employers.
Semantic fluency including task switching predicts academic success in medical school
Authors: Kaufmann Sabrina , Glass Änne , Kropp Peter , Müller-Hilke Brigitte 
Published: December 2020

ObjectivesThe future state treaty on the admission of students to German medical schools calls for a variety of selection criteria among which at least two are required to be independent of school leaving grades. Against this background, the present study investigated achievement motivation and executive functions as predictors of academic success in medical school.Material and methodsSecond year medical students were assessed for executive functioning by using the Tower of London Test (ToL), a German version of the Controlled Oral Word Association Test (COWAT), the Trail Making Test (TMT-A) and for motivation by using the Achievement Motivation Inventory (AMI). Academic success was evaluated twofold, i) whether the first state exam (M1) was passed at the earliest possible, after completion of the second year and ii) via the grades obtained.Results81 out of 226 students enrolled participated in our study. Passing the M1 was best explained by semantic fluency including task switching. Moreover, academically successful students achieved significantly higher levels in the AMI-facets "compensatory effort" and "engagement". All students scored above average in the TMT-A and average in the ToL.ConclusionAlternating semantic fluency—requiring simultaneously inhibition, updating and task shifting—turned out highly predictive of academic success in medical school. Moreover, higher levels in "compensatory effort" and “engagement” suggested that both, increased energy expenditure as response to fear of failure and elevated readiness to exert effort also impacted positively on success.
Alfabetização e a inclusão das crianças com TDAH: Os desafios e as possibilidades / Literacy and inclusion of children with ADHD: The challenges and possibilities
Authors: Vasconcelos Jaine De Souza Lima , Felizardo João Everaldo Alves 
Published: December 2020

Resumo: Este trabalho tem o objetivo de apresentar o transtorno de crianças com TDAH, e assim, apontar caminhos que norteia a inclusão na sala de aula, buscando e analisando entender os fatores que impedem de incluí-lo no ambiente e a razão de tanto despreparo dos professores. Com isso, buscando entender a resistência familiar e da sociedade em incluir essas crianças no ambiente escolar e no meio social. Busca-se descobrir os avanços da inclusão de crianças com TDAH, estudando as leis e os avanços mediados pela educação em oferecer um espaço digno e equilibrado aos pacientes deste transtorno que está muito presente na atualidade. Mesmo que seja pequenos números nas escolas, educadores têm receio e não sabem lidar com esse transtorno. A metodologia que foi utilizada nesse trabalho tem como real objetivo descobrir avanços de inclusão de aluno com esse transtorno e oferecer um ambiente escolar acolhedor e confortável faz toda diferença para que a criança possa assim, sentir-se protegida e confortável para se desenvolver melhor. Este artigo apresenta o que é o transtorno, sua evolução nas leis, bem como mostrar as angústias e falta de profissionais capacitados no meio escolar para atender com equidade esses alunos.
La importancia de Darstellung der antiken Rhetorik en la configuración de la perspectiva retórico-lingüística del joven Nietzsche (1872-1873)
Authors: Fava Fernando 
Published: December 2020

Entre los años 1869 y 1873, la preocupación de Nietzsche comienza a centrarse en las cuestiones relativas al lenguaje y al conocimiento de forma creciente. Luego de experimentar y ensayar con distintas teorías del lenguaje, Nietzsche adopta el abordaje retórico-lingüístico a partir del año 1872. En efecto, el filósofo alemán primero desarrolla la postura retórica-lingüística en el apunte de clases titulado Descripción de la retórica antigua (Darstellung der antiken Rhetorik - 1872), y un año más tarde, en el célebre texto póstumo Sobre verdad y mentira en sentido extramoral (Wahrheit und Lüge im aussermoralischen Sinne -1873). No obstante, son escasos los trabajos académicos que se ocupan exhaustivamente del análisis de Descripción de la retórica antigua y, dentro de este grupo de estudios, son más escasos aun los que se basan en la edición crítica de Colli-Montinari. En este contexto, el objeto del presente trabajo se circunscribe al estudio histórico-genético de la perspectiva retórico-lingüística del joven Nietzsche desarrollada en Descripción de la retórica antigua, a fin de mostrar la importancia que la consideración de este escrito tiene para la comprensión de la concepción tropológica del lenguaje del filósofo alemán durante ese período de tiempo.