bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dominant Terms in the Freshwater and Heat Budgets of the Subpolar North Atlantic Ocean and Nordic Seas From 1992 to 2015
Authors: Tesdal Jan‐Erik , Haine Thomas W. N. 
Published: October 2020

AbstractThe Arctic and subarctic oceans exhibit distinct decadal variations in freshwater and heat content. We describe freshwater and heat budgets with the ECCOv4 reanalysis product and compare budget variability and mechanisms within the subpolar North Atlantic Ocean, Nordic Seas, and Labrador Sea from 1992 to 2015. For all regions, changes in freshwater content are largely anticorrelated with changes in heat content. Since 1995, the subpolar North Atlantic Ocean has undergone a decade of warming and salinification followed by ongoing cooling and freshening. The recent increase in freshwater content and the reduction in heat in the subpolar North Atlantic can largely be attributed to anomalous circulation of mean salinity and temperature, respectively. Interannual variability in heat and freshwater mostly corresponds to boundary fluxes from the subtropics. Meanwhile, the Nordic Seas have undergone an overall warming and salinification from the mid‐1990s to 2015. Salinification is primarily driven by reduced sea ice flux through Fram Strait, while warming is due to changes in both sea surface heating and advective flux. In the last 5 years, Labrador Sea freshwater convergence remained unchanged, as increased inflow via the Baffin Island Current is balanced by increased outflow via the Labrador Current. Hence, the observed freshening of the Arctic Ocean is expected to be an increasingly important source of future freshwater increases in the subpolar North Atlantic. This stands in contrast to variability in freshwater flux from the subtropical North Atlantic, which is associated with variability in the Atlantic Meridional Overturning Circulation.
Development of a Correlated Fe‐Mn Crust Stratigraphy Using Pb and Nd Isotopes and Its Application to Paleoceanographic Reconstruction in the Atlantic
Authors: Josso P. , Horstwood M. S. A. , Millar I. L. , Pashley V. , Lusty P. A. J. , Murton B. 
Published: October 2020

AbstractEight ferromanganese crust samples spanning the complete depth range of Tropic Seamount in the northeast Atlantic were analyzed for Pb and Nd isotopes to reconstruct water mass origin and mixing over the last 75 Ma. Pb isotopes were determined by laser ablation multicollector inductively coupled plasma mass spectrometer (LA‐MC‐ICP‐MS), which enables the rapid production of large, high spatial resolution data sets. This makes it possible to precisely correlate stratigraphy between different samples, compare contemporaneous layers, and create a composite record given the abundance of hiatuses in crusts. Pb and Nd isotope data show the influence of various oceanic and continental end‐members in the northeast Atlantic Ocean. This reflects its evolution from a restricted, isolated basins in the Late Cretaceous with influxes from the Tethys Ocean, to an increasingly well‐mixed, large‐scale basin, with a dominant Southern Ocean signature until the Miocene. Less radiogenic Nd isotope signatures suggest Labrador Sea Water influenced the northeast Atlantic basin as early as 17–15 Ma, flowing through a northern route such as the Charlie‐Gibbs Fracture Zone. Pb and Nd isotopes highlight the increasing influence of Saharan eolian dust input about 7 Ma, imparting a less radiogenic excursion to the binary mixing between North Atlantic water masses and riverine discharge from West and Central Africa. This highlights the influence of eolian dust input on the open ocean Pb and Nd budget and supports an early stage of North African aridification in the Late Miocene. This signature is overprinted about 3 Ma to the present by a strong North Atlantic Deep Water signature following the onset of Northern Hemisphere glaciation.
Benchmarking Forecasting Models for Space Weather Drivers
Authors: Licata Richard J. , Tobiska W. Kent , Mehta Piyush M. 
Published: October 2020

AbstractSpace weather indices are commonly used to drive operational forecasts of various geospace systems, including the thermosphere for mass density and satellite drag. The drivers serve as proxies for various processes that cause energy flow and deposition in the geospace system. Forecasts of neutral mass density are a major uncertainty in operational orbit prediction and collision avoidance for objects in low Earth orbit (LEO). For the strongly driven system, accuracy of space weather driver forecasts is crucial for operations. The High Accuracy Satellite Drag Model (HASDM) currently employed by the U.S. Air Force in an operational environment is driven by four solar and two geomagnetic proxies. Space Environment Technologies (SET) is contracted by the space command to provide forecasts for the drivers. This work performs a comprehensive assessment for the performance of the driver forecast models. The goal is to provide a benchmark for future improvements of the forecast models. Using an archived data set spanning 6 years and 15,000 forecasts across Solar Cycle 24, we quantify the temporal statistics of the model performance.
Wildland fire as an atmospheric source of viable microbial aerosols and biological ice nucleating particles
Authors: Moore Rachel A , Bomar Chelsey , Kobziar Leda N , Christner Brent C 
Published: October 2020

Abstract
The environmental sources of microbial aerosols and processes by which they are emitted into the atmosphere are not well characterized. In this study we analyzed microbial cells and biological ice nucleating particles (INPs) in smoke emitted from eight prescribed wildland fires in North Florida. When compared to air sampled prior to ignition, samples of the air–smoke mixtures contained fivefold higher concentrations of microbial cells (6.7 ± 1.3 × 104 cells m−3) and biological INPs (2.4 ± 0.91 × 103 INPs m−3 active at temperatures ≥ −15 °C), and these data significantly positively correlated with PM10. Various bacteria could be cultured from the smoke samples, and the nearest neighbors of many of the isolates are plant epi- and endophytes, suggesting vegetation was a source. Controlled laboratory combustion experiments indicated that smoke emitted from dead vegetation contained significantly higher numbers of cells, INPs, and culturable bacteria relative to the green shrubs tested. Microbial viability of smoke aerosols based on formazan production and epifluorescent microscopy revealed no significant difference in the viable fraction (~80%) when compared to samples of ambient air. From these data, we estimate each fire aerosolized an average of 7 ± 4 × 109 cells and 2 ± 1 × 108 biological INPs per m2 burned and conclude that emissions from wildland fire are sources of viable microbial aerosols to the atmosphere.
Future climate change vulnerability of endemic island mammals
Authors: Leclerc Camille , Courchamp Franck , Bellard Céline 
Published: October 2020

AbstractDespite their high vulnerability, insular ecosystems have been largely ignored in climate change assessments, and when they are investigated, studies tend to focus on exposure to threats instead of vulnerability. The present study examines climate change vulnerability of islands, focusing on endemic mammals and by 2050 (RCPs 6.0 and 8.5), using trait-based and quantitative-vulnerability frameworks that take into account exposure, sensitivity, and adaptive capacity. Our results suggest that all islands and archipelagos show a certain level of vulnerability to future climate change, that is typically more important in Pacific Ocean ones. Among the drivers of vulnerability to climate change, exposure was rarely the main one and did not explain the pattern of vulnerability. In addition, endemic mammals with long generation lengths and high dietary specializations are predicted to be the most vulnerable to climate change. Our findings highlight the importance of exploring islands vulnerability to identify the highest climate change impacts and to avoid the extinction of unique biodiversity.
Stabilizing hidden room-temperature ferroelectricity via a metastable atomic distortion pattern
Authors: Kim Jeong Rae , Jang Jinhyuk , Go Kyoung-June , Park Se Young , Roh Chang Jae , Bonini John , Kim Jinkwon , Lee Han Gyeol , Rabe Karin M. , Lee Jong Seok , Choi Si-Young , Noh Tae Won , Lee Daesu 
Published: October 2020

AbstractNonequilibrium atomic structures can host exotic and technologically relevant properties in otherwise conventional materials. Oxygen octahedral rotation forms a fundamental atomic distortion in perovskite oxides, but only a few patterns are predominantly present at equilibrium. This has restricted the range of possible properties and functions of perovskite oxides, necessitating the utilization of nonequilibrium patterns of octahedral rotation. Here, we report that a designed metastable pattern of octahedral rotation leads to robust room-temperature ferroelectricity in CaTiO3, which is otherwise nonpolar down to 0 K. Guided by density-functional theory, we selectively stabilize the metastable pattern, distinct from the equilibrium pattern and cooperative with ferroelectricity, in heteroepitaxial films of CaTiO3. Atomic-scale imaging combined with deep neural network analysis confirms a close correlation between the metastable pattern and ferroelectricity. This work reveals a hidden but functional pattern of oxygen octahedral rotation and opens avenues for designing multifunctional materials.
Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation
Authors: Koike Yuhki , Li Bo , Ganji Niloofar , Zhu Haitao , Miyake Hiromu , Chen Yong , Lee Carol , Janssen Lok Maarten , Zozaya Carlos , Lau Ethan , Lee Dorothy , Chusilp Sinobol , Zhang Zhen , Yamoto Masaya , Wu Richard Y. , Inoue Mikihiro , Uchida Keiichi , Kusunoki Masato , Delgado-Olguin Paul , Mertens Luc , Daneman Alan , Eaton Simon , Sherman Philip M. , Pierro Agostino 
Published: October 2020

AbstractNecrotizing enterocolitis (NEC) is a devastating disease of premature infants with high mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal inflammation and ischemia, as well derangements in intestinal microcirculation. Remote ischemic conditioning (RIC) has emerged as a promising tool in protecting distant organs against ischemia-induced damage. However, the effectiveness of RIC against NEC is unknown. To address this gap, we aimed to determine the efficacy and mechanism of action of RIC in experimental NEC. NEC was induced in mouse pups between postnatal day (P) 5 and 9. RIC was applied through intermittent occlusion of hind limb blood flow. RIC, when administered in the early stages of disease progression, decreases intestinal injury and prolongs survival. The mechanism of action of RIC involves increasing intestinal perfusion through vasodilation mediated by nitric oxide and hydrogen sulfide. RIC is a viable and non-invasive treatment strategy for NEC.
Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
Authors: Glavier Marie , Puvanendran Dhenesh , Salvador Dimitri , Decossas Marion , Phan Gilles , Garnier Cyril , Frezza Elisa , Cece Quentin , Schoehn Guy , Picard Martin , Taveau Jean-Christophe , Daury Laetitia , Broutin Isabelle , Lambert Olivier 
Published: October 2020

AbstractThe tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Crystal structures of MexB and of its Escherichia coli homolog AcrB had revealed asymmetric trimers depicting a directional drug pathway by a conformational interconversion (from Loose and Tight binding pockets to Open gate (LTO) for drug exit). It remains unclear how MexB acquires its LTO form. Here by performing functional and cryo-EM structural investigations of MexB at various stages of the assembly process, we unveil that MexB inserted in lipid membrane is not set for active transport because it displays an inactive LTC form with a Closed exit gate. In the tripartite complex, OprM and MexA form a corset-like platform that converts MexB into the active form. Our findings shed new light on the resistance nodulation cell division (RND) cognate partners which act as allosteric factors eliciting the functional drug extrusion.
Preoperative magnetic resonance imaging use and oncologic outcomes in premenopausal breast cancer patients
Authors: Zeng Zexian , Amin Amanda , Roy Ankita , Pulliam Natalie E. , Karavites Lindsey C. , Espino Sasa , Helenowski Irene , Li Xiaoyu , Luo Yuan , Khan Seema A. 
Published: October 2020

AbstractBreast magnetic resonance imaging (MRI) delineates disease extent sensitively in newly diagnosed breast cancer patients, but improved cancer outcomes are uncertain. Young women, for whom mammography is less sensitive, are expected to benefit from MRI-based resection. We identified 512 women aged ≤50 years, undergoing breast-conserving treatment (BCT: tumor-free resection margins and radiotherapy) during 2006–2013 through Northwestern Medicine database queries; 64.5% received preoperative MRI and 35.5% did not. Tumor and treatment parameters were similar between groups. We estimated the adjusted hazard ratios (aHR) for local and distant recurrences (LR and DR), using multivariable regression models, accounting for important therapeutic and prognostic parameters. LR rate with MRI use was 7.9 vs. 8.2% without MRI, aHR = 1.03 (95% CI 0.53–1.99). DR rate was 6.4 vs. 6.6%, aHR = 0.89 (95% CI 0.43–1.84). In 119 women aged ≤40, results were similar to LR aHR = 1.82 (95% CI 0.43–7.76) and DR aHR = 0.93 (95% CI 0.26–3.34). Sensitivity analyses showed similar results. The use of preoperative MRI in women aged ≤50 years should be reconsidered until there is proof of benefit.
A database for risk assessment and comparative genomic analysis of foodborne Vibrio parahaemolyticus in China
Authors: Pang Rui , Li Yanping , Chen Moutong , Zeng Haiyan , Lei Tao , Zhang Junhui , Ding Yu , Wang Juan , Wu Shi , Ye Qinghua , Zhang Jumei , Wu Qingping 
Published: October 2020

AbstractVibrio parahaemolyticus is a major foodborne pathogen worldwide. The increasing number of cases of V. parahaemolyticus infections in China indicates an urgent need to evaluate the prevalence and genetic diversity of this pathogenic bacterium. In this paper, we introduce the Foodborne Vibrio parahaemolyticus genome database (FVPGD), the first scientific database of foodborne V. parahaemolyticus distribution and genomic data in China, based on our previous investigations of V. parahaemolyticus contamination in different kinds of food samples across China from 2011 to 2016. The dataset includes records of 2,499 food samples and 643 V. parahaemolyticus strains from supermarkets and marketplaces distributed over 39 cities in China; 268 whole-genome sequences have been deposited in this database. A spatial view on the risk situations of V. parahaemolyticus contamination in different food types is provided. Additionally, the database provides a functional interface of sequence BLAST, core genome multilocus sequence typing, and phylogenetic analysis. The database will become a powerful tool for risk assessment and outbreak investigations of foodborne pathogens in China.
Cu and Zn isotope ratio variations in plasma for survival prediction in hematological malignancy cases
Authors: Hastuti Agustina A. M. B. , Costas-Rodríguez Marta , Matsunaga Akihiro , Ichinose Takayuki , Hagiwara Shotaro , Shimura Mari , Vanhaecke Frank 
Published: October 2020

AbstractWe have examined potential changes in the isotopic compositions of Fe, Cu and Zn (using multi-collector inductively coupled plasma-mass spectrometry) and the corresponding concentrations (using inductively coupled plasma-atomic emission spectrometry) in plasma from hematological malignancy (HM) patients and assessed their prognostic capability. Together with clinical laboratory test values, data were examined in view of a 5-years survival prediction. Plasma Cu and Zn isotope ratios and their concentrations were significantly different in HM patients compared to matched controls (P < 0.05). Both δ65Cu and δ66Zn values showed significant mortality hazard ratios (HRs) in HM. The group of patients with decreased δ65Cu and increased δ66Zn values showed significantly poorer survival from the early phase (HR 3.9; P = 0.001), forming a unique cohort not identified based on laboratory test values. Well-known prognostic factors for HM, such as the creatinine level, and anemia-related values were highly correlated with the δ66Zn value (P < 0.05). Time-dependent ROC curves based on the δ65Cu or δ66Zn value were similar to that based on the creatinine concentration (a well-known prognostic factor in HM), indicating that δ65Cu or δ66Zn values are useful for prognosis of HM. Variations in stable isotope ratios of essential mineral elements have thus been shown to reflect alterations in their homeostasis due to physiological changes in malignancies with higher sensitivity than concentrations do.
Nutrient consumption-dependent association of a glucagon-like peptide-1 receptor gene polymorphism with insulin secretion
Authors: Nishiya Yuki , Daimon Makoto , Mizushiri Satoru , Murakami Hiroshi , Tanabe Jutaro , Matsuhashi Yuki , Yanagimachi Miyuki , Tokuda Itoyo , Sawada Kaori , Ihara Kazushige 
Published: October 2020

AbstractSince type 2 diabetes (DM) is a life-style related disease, life-style should be considered when association between genetic factors and DM are examined. However, most studies did not examine genetic associations in consideration with lifestyle. Glucagon-like peptide-1 (GLP-1) receptor (GLP1R) mediates the insulinotropic action of GLP-1 in β-cells. We here examined the association while taking into consideration of interactions between the gene polymorphism and various nutrient factors. Participants from the population-based Iwaki study of Japanese subjects held in 2014–2017 with information on nutritional intake evaluated by self-administered dietary history questionnaire, and GLP1R genotype (rs3765467: A/G), were included (n = 1,560). Although not significant, insulin secretion indices assessed by homeostasis model assessment of β-cell function (HOMA-β) in subjects with the GG genotype tended to be lower than in those with the AA+AG genotypes in most groups stratified into tertiles based on daily nutrient consumptions (high, middle, and low). Stratification also showed that the GG genotype was a significant risk for decreased insulin secretion (HOMA-β ≤ 30) even after adjustment for multiple factors (age, body mass index, alcohol consumption), but only in the highest tertiles of energy, protein and carbohydrate consumption in men [odds ratios (95% confidence interval) 3.95 (1.03–15.1), 15.83 (1.58–158.9), and 4.23 (1.10–11.2), respectively]. A polymorphism of the GLP1R gene was associated with decreased insulin secretion in a nutrient consumption-dependent manner in Japanese men, indicating an interaction between GLP1R and nutritional factors in the pathophysiology of DM.
Simple analytical method for determining electrical resistivity and sheet resistance using the van der Pauw procedure
Authors: Oliveira F. S. , Cipriano R. B. , da Silva F. T. , Romão E. C. , dos Santos C. A. M. 
Published: October 2020

AbstractThis work reports an analytical method for determining electrical resistivity (ρ) and sheet resistance (RS) of isotropic conductors. The method is compared with previous numerical solutions and available experimental data showing a universal behavior for isotropic conductors. An approximated solution is also reported allowing one to easily determine ρ and RS for samples either with regular or arbitrary shapes.
Auditory local–global temporal processing: evidence for perceptual reorganization with musical expertise
Authors: Susini Patrick , Jiaouan Sarah Jibodh , Brunet Elena , Houix Olivier , Ponsot Emmanuel 
Published: October 2020

AbstractThe way the visual system processes different scales of spatial information has been widely studied, highlighting the dominant role of global over local processing. Recent studies addressing how the auditory system deals with local–global temporal information suggest a comparable processing scheme, but little is known about how this organization is modulated by long-term musical training, in particular regarding musical sequences. Here, we investigate how non-musicians and expert musicians detect local and global pitch changes in short hierarchical tone sequences structured across temporally-segregated triplets made of musical intervals (local scale) forming a melodic contour (global scale) varying either in one direction (monotonic) or both (non-monotonic). Our data reveal a clearly distinct organization between both groups. Non-musicians show global advantage (enhanced performance to detect global over local modifications) and global-to-local interference effects (interference of global over local processing) only for monotonic sequences, while musicians exhibit the reversed pattern for non-monotonic sequences. These results suggest that the local–global processing scheme depends on the complexity of the melodic contour, and that long-term musical training induces a prominent perceptual reorganization that reshapes its initial global dominance to favour local information processing. This latter result supports the theory of “analytic” processing acquisition in musicians.
Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury
Authors: Evans Stephen J. , Roberts Aled E. L. , Morris Andrew Conway , Simpson A. John , Harris Llinos G. , Mack Dietrich , Jenkins Rowena E. , Wilkinson Thomas S. 
Published: October 2020

AbstractMethicillin-resistantStaphylococcus aureus(MRSA) is an important cause of ventilator-associated pneumonia (VAP). Patients with VAP have poorly functioning neutrophils, related to increased levels of the complement fragment C5a. The antibiotic linezolid has been useful in controlling MRSA-related VAP infections; however clinical benefit does not always correlate with antimicrobial effect, suggesting the possibility of immunomodulatory properties. Here the effects of linezolid on healthy and dysfunctional neutrophils (modelled by C5a-induced injury) was investigated. Functional assays (killing, phagocytosis, transmigration, and respiratory burst) were used to assess the effects of pre-, co- and post-incubating linezolid (0.4–40 mg/L) with healthy neutrophils relative to those with C5a-induced injury. C5a decreased neutrophil killing, and phagocytosis of MRSA. Furthermore, C5a significantly decreased neutrophil transmigration to IL-8, but did not affect respiratory burst. Co-incubation of linezolid significantly improved killing of MRSA by dysfunctional neutrophils, which was supported by concomitant increases in phagocytosis. Conversely linezolid impaired killing responses in healthy neutrophils. Pre- or post-incubation of linezolid prior or following C5a induced injury had no effect on neutrophil function. This study suggests that linezolid has immunomodulatory properties that protect human neutrophils from injury and provides insight into its mode of action beyond a basic antibiotic.