bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Content Analysis of Cancer‐Related Changes in Perceptions of Self, Relationships, and Health Among LGBTQI+ Cancer Survivors Across the Life Course: Findings From OUT: The National Cancer Survey
Authors: Waters Austin R. , Jones Shaun R. , Uppalapati Manuela , Gududuru Akshay , Bono Madeline H. , Hecht Hillary K. , Scout N. F. N. , Kent Erin E. 
Published: December 2024

ABSTRACTBackgroundThe LGBTQI+ population makes up at least 7.6% of the US population. LGBTQI+ populations are at increased risk of experiencing LGBTQI+‐related discrimination and cis‐heteronormativity in healthcare leading to poorer health outcomes throughout the cancer care continuum. We aimed to explore LGBTQI+ cancer survivors' perspectives of how cancer has changed their perceptions of self and relationships using data from OUT: The National Cancer Survey.MethodsWe conducted an inductive qualitative content analysis of responses to four open‐ended questions from OUT: The National Cancer Survey. Data were collected from September 2020 to April 2021. Eligible participants were 18 years of age or older at time of survey, had been previously diagnosed with cancer, identified as LGBTQI+, and currently lived in the US. Open‐ended survey questions asked about the impact of cancer on LGBTQI+ cancer survivors' perceptions of self and relationships. To maximize inter‐rater reliability, 20% of the survey responses were double coded. Chi‐squared tests assessed differences in changes across the life‐course.ResultsOf the participants in the OUT survey (N = 2382), 86.9% (N = 2069) provided responses to at least one of the four open‐ended questions. The content analysis sample participants were primarily aged 40–59 (39.3%) and 60–79 (49.4%), gay (54.7%), cisgender men (59.4), White (89.7%), and not on active treatment (77.4%). A total of 5179 codes were applied to the 2069 responses. A total of 5 overarching categories and 18 sub‐categories were identified. Themes included: (1) changes in perceptions of self; (2) changes to relationships; (3) changes to health and (4) LGBTQI+ specific unmet needs. The most commonly reported categories were changes in perceptions of self (77%, n = 1593) and changes to health (47%, n = 972). Most cancer‐related changes were more frequently reported by young adult survivors.ConclusionsThis content analysis illuminates the unique challenges that the LGBTQI+ population faces while navigating through the cancer care continuum.
Morpholine Anchored Fluorogenic Toolkit: Unveiled Disease Allied Protein Fibrillation in Lysosomal Compartment of Live‐Cell and Drosophila Models
Authors: P. Kavyashree , Wilson Harry , Silswal Akshay , Mishra Lopamudra , Bhattacharya Debapriya , Mishra Monalisa , Koner Apurba Lal 
Published: December 2024

AbstractThe aberrant accumulation of cytotoxic protein aggregates is a hallmark of various neurodegenerative and non‐neurodegenerative ailments, necessitating the development of sensitive and selective tools for their detection. Herein, we report a series of morpholine‐anchored fluorescent probes, denoted as SC‐nmor (n = 2, 4, 6), designed for facile visualization of protein aggregates. These probes display notable changes in their photophysical properties upon binding with protein aggregates, owing to their high sensitivity to the fibrillar microenvironment. Specifically, the SC‐4mor probe demonstrates strong selectivity for aggregated insulin proteins over native insulin, accompanied by a significant enhancement in fluorescence lifetime. Live‐cell imaging reveals an exclusive localization at the lysosomal compartment. This feature enables the visualization of lysosomal accumulated protein fibrils induced with pepstatin A. Additionally, in vivo assessments on genetically mutated and dietary‐modified Drosophila melanogaster, representing neurodegenerative and non‐neurodegenerative disease models, demonstrate staining of protein aggregates. The enhanced emission from the eye lobes of Aβ‐mutated and HSD brain samples, suggesting that SC‐4mor can exhibit adequate retention in the brain with minimal biological toxicity. SC‐4mor also shows its capability to cross the blood–brain barrier in mice model. Consequently, SC‐4mor emerges as a promising marker for detecting and monitoring neurotoxic protein fibrillation in live cells and animal models, offering potential insights into the pathogenesis and progression of protein aggregation.
Localized Microrobotic Delivery of Enzyme‐Responsive Hydrogel‐Immobilized Therapeutics to Suppress Triple‐Negative Breast Cancer
Authors: Tian Mingzhen , Keshavarz Meysam , Demircali Ali Anil , Han Bing , Yang Guang‐Zhong 
Published: December 2024

AbstractTriple‐negative breast cancer (TNBC), characterized by its aggressive metastatic propensity and lack of effective targeted therapeutic options, poses a major challenge in oncological management. A proof‐of‐concept neoadjuvant strategy aimed at inhibiting TNBC tumor growth and mitigating metastasis through a localized delivery of chemotherapeutics is reported in this paper. This approach addresses the limitations in payload capacity and stimuli responsiveness commonly associated with microrobotics in oncology. A hydrogel‐based system is developed for the immobilization of chemotherapeutic agents, subsequently encapsulated within magnetically responsive microrobots. This design leverages external magnetic fields to facilitate the precise navigation and localization of the therapeutic agents directly to the tumor site. The efficacy of this approach is demonstrated in an animal model, in which a significant 14‐fold reduction in tumor size and suppression of metastasis to critical organs such as the liver and lungs are observed. Crucially, the drug release mechanism is engineered to be responsive to the tumor microenvironment and is regulated by the overexpression of the enzymatic activity of matrix metalloproteinases (MMP2 and MMP9) in TNBC tumors, triggering the degradation of the hydrogel matrix, leading to controlled release of the immobilized therapeutic drug. This ensures that the therapeutic action is localized, reducing systemic toxicity and enhancing treatment efficacy. These findings suggest that this neoadjuvant approach holds promise for broader applications in other cancer types.
Zwitterion Interlocked Diarylethene Molecules Order, Unconnected Diarylethene Molecules Disorder
Authors: Wi Youngjae , Kang Dong‐Gue , Ko Hyeyoon , Oh Mintaek , Jang Junhwa , Rim Minwoo , Lee Kyung Min , Godman Nicholas P. , McConney Michael E. , Jeong Kwang‐Un 
Published: December 2024

AbstractA diarylethene‐based zwitterionic molecule (DZM) is newly synthesized for the development of smart films exhibiting reversible color change and switchable ionic conductivity in response to external light stimuli. This dual molecular building block is constructed through zwitterionic interlocking and strong phase separation between the dendron‐shaped aliphatic tails and the diarylethene head. Uniaxial shear coating and molecular self‐assembly result in anisotropically oriented nanostructures, which are further solidified through photopolymerization. In the absence of zwitterionic interlocking, DZM fails to form ordered structures and remains disordered. The anisotropically oriented nanostructures of DZM exhibit polarization‐dependent photochromic properties despite the inherent low anisotropy of a single diarylethene chromophore. Structural analysis reveals that the zwitterion‐interlocked molecular building block self‐assemble into nanocolumns that align uniaxially during the shear coating process. Alternating ultraviolet and visible light reversibly switches the ionic conductivity of the DZM thin film and a change in color is observed due to the photoisomerization of the diarylethene chromophore. Utilizing the polarization‐dependent photochromic properties, light‐sensitive smart thin films are demonstrated with potential applications in anti‐counterfeiting labels and sensors.
A Corrected Score Function Framework for Modelling Circadian Gene Expression
Authors: Gorczyca Michael T. , McDonald Tavish M. , Sefas Justice D. 
Published: December 2024

ABSTRACTMany biological processes display oscillatory behaviour based on an approximately 24 h internal timing system specific to each individual. One process of particular interest is gene expression, for which several circadian transcriptomic studies have identified associations between gene expression during a 24 h period and an individual's health. A challenge with analysing data from these studies is that each individual's internal timing system is offset relative to the 24 h day‐night cycle, where day–night cycle time is recorded for each collected sample. Laboratory procedures can accurately determine each individual's offset and determine the internal time of sample collection. However, these laboratory procedures are labour‐intensive and expensive. In this paper, we propose a corrected score function framework to obtain a regression model of gene expression given internal time when the offset of each individual is too burdensome to determine. A feature of this framework is that it does not require the probability distribution generating offsets to be symmetric with a mean of zero. Simulation studies validate the use of this corrected score function framework for cosinor regression, which is prevalent in circadian transcriptomic studies. Illustrations with data from three circadian transcriptomic studies further demonstrate that the proposed framework consistently mitigates bias relative to using a score function that does not account for this offset.
Enhancing concrete sustainability with spent diatomaceous earth from the wine industry: Long‐term experimental and statistical analysis
Authors: Magalhães Leandro J. R. , Ferreira Débora Macanjo , Ramos‐Gavilán Ana Belén 
Published: December 2024

AbstractSpent diatomaceous earth, a by‐product of wine filtration, holds significant promise for use in concrete mixtures due to its pozzolanic properties, which enhance concrete performance. This research explores the application of spent calcined diatomaceous earth (SCDE), heat‐treated at 700°C to remove organic content, as a partial substitute for cement or sand in concrete. The high silica content of SCDE contributes to the formation of additional calcium silicate hydrates during the hydration process, leading to improvements in mechanical strength over time. The study includes a preliminary analysis of cement replacements ranging from 5% to 10% and sand replacements from 2.5% to 15%, assessing their effects on workability, density, water absorption, and compressive strength at 7 and 28 days. The testing program focuses on three key compositions: the reference concrete and optimal mixtures with 10% cement and 5% sand replacements. Compressive strength tests are conducted at 7, 28, 90, 180, and 360 days. The results, validated through ANOVA, demonstrate the influence of SCDE on concrete strength over time, with distinctive behavior patterns identified for different mixtures. The strength of concrete with replacements correlates with the reference strength, with a multiplicative factor that varies from 7 to 90 days and then. When SCDE replaces cement, the factor is less than one before 28 days due to the slow pozzolanic reaction, whereas for sand replacement, it always exceeds one because of the initial filler effect. After 90 days, the strength multiplicative factors are 1.13 for cement replacement and 1.30 for sand replacement, demonstrating the potential of SCDE for sustainable concrete manufacturing and its positive long‐term impact on mechanical performance.
Tax, Trade, and Investment for Green Transition
Authors: Tandon Suranjali 
Published: December 2024

AbstractThe carbon border adjustment levy by the EU is meant to address the issue of carbon leakage as a result of high carbon prices. The levy will come into effect in 2026 and therefore will impact trade with developing countries. The imposition of the levy will raise the costs to trade and have adverse economic consequences. This paper explores the implication that the Carbon Border Adjustment Mechanism (CBAM) will have for developing countries and whether the levy works against the principle of common but differentiated responsibility enshrined in the Paris Agreement. At the same time, the international corporate tax reform limits the possibility for countries to offer tax incentives, which means if developing countries are to transition to green energy they would have to do so without the possibility of offering these incentives. Developing countries thus find themselves in a bind while making their low carbon transition. This paper covers the two aspects of a green transition.
Introduction to Part II
Authors: Chaisse Julien 
Published: December 2024

AbstractThe interconnected nature of the global economy ensures that there are no clear boundaries between the realms of tax, trade, and investment law. Instead, every nation state confronts a bewildering mix of policy choices across these regulatory areas as well as various constraints on the ability to achieve national policy priorities. Every cross-border business or investment decision accordingly involves navigating a web of overlapping regulatory regimes characterized as much by conflict as coordination.
GC–MS, 1H and 13C NMR, and physiochemical properties of oils of Dacryodes Edulis and Persea Americana
Authors: Eze J. C. , Nwadibia P. C. , Anyaogu D. I. , Abugu H. O. , Ejikeme P. M. 
Published: December 2024

AbstractA comparative investigation was carried out on the seed oils of P. americana and D. edulis for their physiochemical properties and spectroscopic properties. Oils were extracted from the respective powdered seeds using Soxhlet extraction technique giving 18.63% and 45.49% yields for P. americana and D. edulis, respectively. The seed oils were subjected to physiochemical analysis using standard protocols as prescribed by the American Oil Chemist Society (AOCS) and the American Society for Testing and Materials (ASTM). The fatty acid content was determined using Gas Chromatography, Proton (1H) and Carbon-13 (13C) Nuclear Magnetic Resonance spectroscopy. The results indicates that linoleic acid is the most unsaturated fatty acid, while stearic acid is the most saturated fatty acid in both oils. Unsaturated fatty acid peaks for olefinic H were observed at 5.34 and 5.31 ppm for P. americana and at 5.43 and 5.32 ppm for D. edulis oils in 1H-NMR. For 13C-NMR, the presence of C with triple bond attached to an alkyl group was observed at 85 ppm for the P. americana, while similar peak was observed for D. edulis at 128.21 to 130.1 ppm. The chemical characterization of the oils gave iodine values of 51.86 mgI2/g for P. americana oil and 48.72 mgI2/g for D. edulis oil. Similarly, acid values of 3.45 mg KOH/kg and 5.76 mg KOH/kg were obtained for P. americana and D. edulis seed oils respectively. The physiochemical and spectroscopic results obtained showed that P. americana and D. edulis seed oils have the potential for use in a number of industrial applications.
Telemedicine in the Digital Era: Navigating the International Legal Landscape to Expand Global Healthcare Access
Authors: Qizi Yusupova Faringiz Uktam 
Published: December 2024

Abstract
The global healthcare landscape faces mounting challenges, from resource constraints and rural healthcare access in Uzbekistan, to aging populations and rising chronic disease rates in Europe. Amidst these, the digital transformation in healthcare and the study of international legal aspects governing telemedicine services have emerged as crucial priorities. This article examines the international legal framework for telemedicine, analyzing key documents of the United Nations (UN), World Health Organization (WHO), International Telecommunication Union (ITU), and various regional bodies. It highlights the absence of a universal agreement that comprehensively addresses telemedicine regulation and data protection issues. The article explores national regulatory efforts and identifies gaps in the current fragmented approach. Recommendations include establishing a dedicated subsidiary body under the UN Committee on Economic, Social and Cultural Rights (CESCR) to oversee telemedicine-related matters and codifying scattered norms into a coherent framework. Strengthening the international legal basis for telemedicine can help expand access to vital healthcare services and improve global health outcomes.
Print media and egalitarianism in 1960s Eswatini: Izwi lama Swazi and the columnist ‘Kadebona’
Authors: Cabrita Joel 
Published: December 2024

AbstractFrom 1950 to 1963, a columnist named ‘Kadebona’ (The Experienced One) published regular pieces in Izwi lama Swazi (The Voice of the Swazi), the vernacular newspaper of the British protectorate of Swaziland (now named Eswatini). Although lacking definitive evidence, it is probable that Kadebona was John J. Nquku, a leading political figure of colonial Eswatini. Kadebona’s 300-plus columns positioned themselves as meeting places for the embryonic Swati nation. In contrast to the closed-door discussions of those in power, Kadebona’s columns styled themselves as transparent platforms for a give-and-take debate among emaSwati (as residents of Eswatini were called). Kadebona not only ‘spoke’ via his columns; he also expected replies on the part of the nation. His column was a space available to all, ‘where the rich and the poor, and where leaders and their followers, all meet’. In a period of debate over the future of the independent Swati nation, Kadebona’s columns encouraged all emaSwati to shape their country, and allowed all perspectives audibility via the column and ‘Letters to the Editor’. At the same time, however, there were distinct limits to the egalitarian public summoned through these articles. While Kadebona encouraged all emaSwati regardless of rank or class to speak up, he was far less welcoming towards other voices, including women and youths. This article provides an introduction to these fraught columns, a small sample of which are presented here, both in their isiZulu original and in English translation (siSwati – the language spoken by emaSwati – had no authorized written form well into the 1960s; instead, the South African isiZulu was used for written communication). In what follows, I provide Izwi lama Swazi’s history, discuss the emergence of Kadebona as a columnist in the 1950s, and comment on some of his key concerns.
Ideals of equations for elements in a free group and Stallings folding
Authors: Ascari Dario 
Published: December 2024

Abstract
Let

$H\le F$

be two finitely generated free groups. Given

$g\in F$

, we study the ideal

$\mathfrak I_g$

of equations for g with coefficients in H, i.e. the elements

$w(x)\in H*\langle x\rangle$

such that

$w(g)=1$

in F. The ideal

$\mathfrak I_g$

is a normal subgroup of

$H*\langle x\rangle$

, and it’s possible to algorithmically compute a finite normal generating set for

$\mathfrak I_g$

; we give a description of one such algorithm, based on Stallings folding operations. We provide an algorithm to find an equation in w(x)\in

$\mathfrak I_g$

with minimum degree, i.e. such that its cyclic reduction contains the minimum possible number of occurrences of x and x−1; this answers a question of A. Rosenmann and E. Ventura. More generally, we show how to algorithmically compute the set Dg of all integers d such that

$\mathfrak I_g$

contains equations of degree d; we show that Dg coincides, up to a finite set, with either

$\mathbb N$

or

$2\mathbb N$

. Finally, we provide examples to illustrate the techniques introduced in this paper. We discuss the case where

${\text{rank}}(H)=1$

. We prove that both kinds of sets Dg can actually occur. We show that the equations of minimum possible degree aren’t in general enough to generate the whole ideal

$\mathfrak I_g$

as a normal subgroup.
Does the Orthodox tradition have anything to contribute to analytic theology?
Authors: Cuneo Terence 
Published: December 2024

Abstract
A prominent challenge to analytic theology charges that its methodology leads to idolatry. This article explores a response to this challenge that draws upon the Eastern Orthodox apophatic tradition. Apophatic approaches, which emphasize how little we can truthfully say or know about God, are not exclusive to Orthodox Christianity. But these views take a unique form within the tradition insofar as they accord a prominent role to the distinction between God’s essence and God’s energies. The divine essence is what it is to be God, what God is as such, what God is at God’s core. In contrast, the divine energies are properties, modes, or activities of God not included in the divine essence but intimately related to it. Proponents of the distinction have claimed that it can help theorists to navigate the Christian tradition’s cataphatic and apophatic commitments, which don’t always sit comfortably together. This article argues that there are ways of crafting the essence/energy distinction that can also help to address the ‘Idolatry Argument’ against analytic theology.
Hope in a paranoid place? Critique, utopianism and prefigurative policy reform
Authors: Hewer Rebecca , Collier Ben 
Published: December 2024

Abstract
We are living through cruel and frightening times. How should a progressive policy studies respond? Critique undoubtedly plays a role: the task of exposing the structural conditions, political interests and power asymmetries that lie beneath the ‘prosaic surface’ of policy is an urgent one. But are these primarily deconstructive efforts enough? Can they lead us out of this quagmire, alone? In this article, we argue that something additional – something more generative and hopeful – is also required. In response, we introduce ‘critical utopian policy analysis’ (CUPA) a methodological elaboration of critical policy analysis (CPA) designed to support its use in both deconstructive and reconstructive policy efforts. This approach builds on the theoretical offerings of critical policy analysis, utopianism and prefiguration, to posit a methodological embrace of critique, imagination, enactment and play. It seeks to mobilise a complex nexus of affect – including heartbreak and hope – to motivate and support a range of intellectual undertakings and emancipatory politics.
A six-year epidemiological study of selected zoonotic abortifacient agents in ovine and caprine foetuses in Türkiye
Authors: Şevik Murat 
Published: December 2024

Abstract
Abortion is one of the major threats to the livestock industry, and it also poses significant threats to public health since some of the abortifacient agents are considered zoonotic. Chlamydia abortus (C. abortus), Coxiella burnetii (C. burnetii), Listeria monocytogenes (L. monocytogenes), and Cache Valley virus (CVV) are recognized as important zoonotic and abortifacient agents of reproductive failure in small ruminants. This study determined the prevalence of these agents in ovine and caprine foetuses in Türkiye. A total of 1 226 foetuses were collected from the sheep (n = 1 144) and goats (n = 82) from different flocks between 2012 and 2017. Molecular detection methods were used to detect C. abortus, C. burnetii, and L. monocytogenes DNA and CVV RNA in aborted foetuses. In this study, C. abortus was the most prevalent abortifacient agent among the investigated ovine (264/1144) and caprine (12/82) foetuses, followed by C. burnetii with a frequency of 2.8% (32/1144) and 8.5% (7/82) in ovine and caprine foetuses, respectively. L. monocytogenes DNA was detected in 28 (2.4%) and 2 (2.4%) of the ovine and caprine foetuses, respectively. However, CVV RNA was not detected. Although the predominant mixed infection was C. abortus and C. burnetii, mixed infection of C. abortus and L. monocytogenes, and C. burnetii and L. monocytogenes were also found. The information presented in this study contributes to the understanding of the roles of C. abortus, C. burnetii, L. monocytogenes, and CVV in abortions in small ruminants, and could be beneficial for developing more effective control strategies.