bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents
Authors: Tomar Vartika , Kumar Neeraj , Tomar Ravi , Sood Damini , Dhiman Neerupma , Dass Sujata K. , Prakash Satya , Madan Jitender , Chandra Ramesh 
Published: December 2019

AbstractIn present investigation, an attempt was undertaken to modify the C-9 position of noscapine (Nos), an opium alkaloid to yield 9 -hydroxy methyl and 9 -carbaldehyde oxime analogues for augmenting anticancer potential. The synthesis of 9-hydroxy methyl analogue of Nos was carried out by Blanc reaction and 9-carbaldehyde oxime was engineered by oxime formation method and characterized using FT-IR, 1H NMR, 13C NMR, mass spectroscopy, and so on techniques. In silico docking techniques informed that 9-hydroxy methyl and 9-carbaldehyde oxime analogues of Nos had higher binding energy score as compared to Nos. The IC50 of Nos was estimated to be 46.8 µM signficantly (P < 0.05) higher than 8.2 µM of 9-carbaldehyde oxime and 4.6 µM of 9-hydroxy methyl analogue of Nos in U87, human glioblastoma cells. Moreover, there was significant (P < 0.05) difference between the IC50 of 9-carbaldehyde oxime and 9-hydroxy methyl analogue of Nos. Consistent to in vitro cytotoxicity data, 9-hydroxy methyl analogue of Nos induced significantly (P < 0.05) higher degree of apoptosis of 84.6% in U87 cells as compared to 78.5% and 64.3% demonstrated by 9-carbaldehyde oxime and Nos, respectively. Thus the higher therapeutic efficacy of 9-hydroxy methyl analogue of Nos may be credited to higher solubility and inhibitory constant (K).
Interpretation of detections of volcanic activity at Ioto Island obtained from in situ seismometers and remote hydrophones of the International Monitoring System
Authors: Matsumoto Hiroyuki , Zampolli Mario , Haralabus Georgios , Stanley Jerry , Mattila James , Meral Özel Nurcan 
Published: December 2019

AbstractIn-situ seismic observations identified that volcanic activity of Ioto (formerly Iwojima), a volcanic island offshore Japan, increased in early September 2018. Observations of discolored nearshore waters and a splash reported by a local flyover provided evidence for a connection between undersea eruptions and recorded seismic activity. However there remain uncertainties as to when the undersea eruption series commenced and how much of the in-situ seismic activity recorded on the island was associated with volcanic earthquakes versus undersea eruptions. During this period, a large number of underwater acoustic (hydroacoustic) signals were recorded by the Comprehensive Nuclear-Test-Ban Treaty (CTBT) International Monitoring System (IMS) hydroacoustic station HA11, at Wake Island (U.S. Territory), in the northwestern Pacific Ocean with signals with directions of arrival consistent with sources located at Ioto. The analysis presented here interprets signal features of the remote hydroacoustic recordings provided by HA11 in order to attempt to distinguish between volcanic earthquake signals and undersea eruption signals originating from Ioto. Histograms of hydroacoustic events interpreted as originating from Ioto correlate well with the in-situ seismic observations at Ioto in the early stage of volcanic activity. The results presented suggest that around 75% of the signals detected at HA11 with directions of arrival consistent with Ioto as their origin could be associated with undersea eruptions, supporting the conclusion that the IMS hydroacoustic stations can contribute to volcanic event remote monitoring.
Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation
Authors: Sugimoto Jun , Schust Danny J. , Kinjo Tadatsugu , Aoki Yoichi , Jinno Yoshihiro , Kudo Yoshiki 
Published: December 2019

AbstractWe previously identified suppressyn (SUPYN), a placental protein that negatively regulates the cell fusion essential for trophoblast syncytialization via binding to the trophoblast receptor for syncytin-1, ASCT2, and hypothesized that SUPYN may thereby regulate cell-cell fusion in the placenta. Here, we redefine in vivo SUPYN localization using specific monoclonal antibodies in a rare early placental sample, showing SUPYN localization in villous and extravillous trophoblast subtypes, the decidua and even in placental debris in the maternal vasculature. In human trophoblast cell lines, we show SUPYN alters ASCT2 glycosylation within the secretory pathway and that this binding is associated with inhibition of cell fusion. Using newly-optimized trophoblast isolation protocols that allow tracking of ex vivo cell fusion, we present transcription and translation dynamics of fusion-related proteins over 96 hours in culture and the effects of changes in ambient oxygen levels on these processes. We report converse syncytin-1 and SUPYN transcriptional and translational responses to surrounding oxygen concentrations that suggest both are important in the effects of hypoxia and hyperoxia on placental syncytialization. Our results suggest that SUPYN’s anti-fusogenic properties may be exerted at several sites in the maternal body and its dysregulation may be associated with diseases of abnormal placentation.
Pectic Oligosaccharides from Cranberry Prevent Quiescence and Persistence in the Uropathogenic Escherichia coli CFT073
Authors: Sun Jiadong , Deering Robert W. , Peng Zhiyuan , Najia Laila , Khoo Christina , Cohen Paul S. , Seeram Navindra P. , Rowley David C. 
Published: December 2019

AbstractUrinary tract infections (UTIs) caused by Escherichia coli create a large burden on healthcare and frequently lead to recurrent infections. Part of the success of E. coli as an uropathogenic bacterium can be attributed to its ability to form quiescent intracellular reservoirs in bladder cells and its persistence after antibiotic treatment. Cranberry juice and related products have been used for the prevention of UTIs with varying degrees of success. In this study, a group of cranberry pectic oligosaccharides (cPOS) were found to both inhibit quiescence and reduce the population of persister cells formed by the uropathogenic strain, CFT073. This is the first report detailing constituents of cranberry with the ability to modulate these important physiological aspects of uropathogenic E. coli. Further studies investigating cranberry should be keen to include oligosaccharides as part of the ‘active’ cocktail of chemical compounds.
Treatment evaluation to improve preventing mother to child transmission among women with syphilis
Authors: Gong Tian , Shao Yan , Liu Juning , Wu Qianlan , Xu Rong , Sun Li , Peng Xiaoju 
Published: December 2019

AbstractThe aim of this study was to evaluate the effectiveness of preventing mother to child syphilis transmission to improve pregnancy outcomes. We performed a retrospective analysis of municipal databases of mother-to-child syphilis transmission. Pregnant women with syphilis were included. Group specific pregnancy outcomes were analyzed according to treatment. A total of 28 pregnant women were diagnosed with syphilis in 2012; 321 were diagnosed with syphilis in 2018. A prevalence of 0.14% was observed amongst pregnant women in Suzhou city from 2012–2018. Primary treatments included benzathine penicillin, ceftriaxone sodium or erythromycin when patients were allergic to Benzathine penicillin. The treatment coverage was 81.57%, and only 52.86% of pregnant women were adequately treated. Adverse pregnant outcomes were higher amongst untreated women. Expanding early screening coverage and promoting treatment were key to improving pregnancy outcomes amongst women with syphilis.
Encoding kirigami bi-materials to morph on target in response to temperature
Authors: Liu Lu , Qiao Chuan , An Haichao , Pasini Damiano 
Published: December 2019

AbstractShape morphing in response to an environmental stimulus, such as temperature, light, and chemical cues, is currently pursued in synthetic analogs for manifold applications in engineering, architecture, and beyond. Existing strategies mostly resort to active, namely smart or field responsive, materials, which undergo a change of their physical properties when subjected to an external stimulus. Their ability for shape morphing is intrinsic to the atomic/molecular structure as well as the mechanochemical interactions of their constituents. Programming shape changes with active materials require manipulation of their composition through chemical synthesis. Here, we demonstrate that a pair of off-the-shelf passive solids, such as wood and silicone rubber, can be topologically arranged in a kirigami bi-material to shape-morph on target in response to a temperature stimulus. A coherent framework is introduced to enable the optimal orchestration of bi-material units that can engage temperature to collectively deploy into a geometrically rich set of periodic and aperiodic shapes that can shape-match a predefined target. The results highlight reversible morphing by mechanics and geometry, thus contributing to relax the dependence of current strategies on material chemistry and fabrication.
Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice
Authors: Wang Sheng , Jiang Wei , Ouyang Ting , Shen Xiu-Yin , Wang Fen , Qu Yu-hua , Zhang Min , Luo Tao , Wang Hua-Qiao 
Published: December 2019

AbstractAlzheimer’s disease (AD) is a complex disorder influenced by both genetic and environmental components and has become a major public health issue throughout the world. Oxidative stress and inflammation play important roles in the evolution of those major pathological symptoms. Jatrorrhizine (JAT), a main component of a traditional Chinese herbal, coptidis rhizome, has been shown to have neuroprotective effects and we previously showed that it is also able to clear oxygen free radicals and reduce inflammatory responses. In this study, we demonstrated that JAT administration could alleviate the learning and memory deficits in AD. Furthermore, we also found that JAT treatment reduced the levels of Aβ plaques in the cortex and hippocampus of APP/PS1 double-transgenic mice. Other studies suggest that there are gut microbiome alterations in AD. In order to explore the underlying mechanisms between gut microbiota and AD, DNA sequencing for 16s rDNA V3-V4 was performed in fecal samples from APP/PS1 transgenic mice and C57BL/6 wild-type (WT) mice. Our results indicated that APP/PS1 mice showed less Operational Taxonomic Units (OTUs) abundance in gut microbiota than WT mice and with different composition. Furthermore, JAT treatment enriched OTUs abundance and alpha diversity in APP/PS1 mice compared to WT mice. High dose of JAT treatment altered the abundance of some specific gut microbiota such as the most predominant phylum Firmicutes and Bacteroidetes in APP/PS1 mice. In conclusion, APP/PS1 mice display gut dysbiosis, and JAT treatment not only improved the memory deficits, but also regulated the abundance of the microbiota. This may provide a therapeutic way to balance the gut dysbiosis in AD patients.
Oblique Electrostatic Inkjet-Deposited TiO2 Electron Transport Layers for Efficient Planar Perovskite Solar Cells
Authors: Shahiduzzaman Md. , Sakuma Toshiharu , Kaneko Tetsuya , Tomita Koji , Isomura Masao , Taima Tetsuya , Umezu Shinjiro , Iwamori Satoru 
Published: December 2019

AbstractIn this study, a new, simple, and novel oblique electrostatic inkjet (OEI) technique is developed to deposit a titanium oxide (TiO2) compact layer (CL) on fluorine-doped tin oxide (FTO) substrate without the need for a vacuum environment for the first time. The TiO2 is used as electron transport layers (ETL) in planar perovskite solar cells (PSCs). This bottom-up OEI technique enables the control of the surface morphology and thickness of the TiO2 CL by simply manipulating the coating time. The OEI-fabricated TiO2 is characterized tested and the results are compared with that of TiO2 CLs produced by spin-coating and spray pyrolysis. The OEI-deposited TiO2 CL exhibits satisfactory surface coverage and smooth morphology, conducive for the ETLs in PSCs. The power-conversion efficiencies of PSCs with OEI-deposited TiO2 CL as the ETL were as high as 13.19%. Therefore, the present study provides an important advance in the effort to develop simple, low-cost, and easily scaled-up techniques. OEI may be a new candidate for depositing TiO2 CL ETLs for highly efficient planar PSCs, thus potentially contributing to future mass production.
Cyanidioschyzon merolae aurora kinase phosphorylates evolutionarily conserved sites on its target to regulate mitochondrial division
Authors: Kato Shoichi , Okamura Erika , Matsunaga Tomoko M. , Nakayama Minami , Kawanishi Yuki , Ichinose Takako , Iwane Atsuko H. , Sakamoto Takuya , Imoto Yuuta , Ohnuma Mio , Nomura Yuko , Nakagami Hirofumi , Kuroiwa Haruko , Kuroiwa Tsuneyoshi , Matsunaga Sachihiro 
Published: December 2019

AbstractThe mitochondrion is an organelle that was derived from an endosymbiosis. Although regulation of mitochondrial growth by the host cell is necessary for the maintenance of mitochondria, it is unclear how this regulatory mechanism was acquired. To address this, we studied the primitive unicellular red alga Cyanidioschyzon merolae, which has the simplest eukaryotic genome and a single mitochondrion. Here we show that the C. merolae Aurora kinase ortholog CmAUR regulates mitochondrial division through phosphorylation of mitochondrial division ring components. One of the components, the Drp1 ortholog CmDnm1, has at least four sites phosphorylated by CmAUR. Depletion of the phosphorylation site conserved among eukaryotes induced defects such as mitochondrial distribution on one side of the cell. Taken together with the observation that human Aurora kinase phosphorylates Drp1 in vitro, we suggest that the phosphoregulation is conserved from the simplest eukaryotes to mammals, and was acquired at the primitive stage of endosymbiosis.
Development of a topical tissue cross-linking solution using sodium hydroxymethylglycinate (SMG): viscosity effect
Authors: Mehta Jaya , Takaoka Anna , Zyablitskaya Mariya , Nagasaki Takayuki , Paik David C. 
Published: December 2019

Abstract
Hyperviscosity agents are commonly used in ophthalmic formulations for improving corneal drug penetration by increasing tissue contact time. One such viscosity agent is hydroxypropyl methylcellulose (HPMC). HPMC has been used in riboflavin solutions for photochemical UVA cross-linking (CXL). Sodium hydroxymethylglycinate (SMG) is a small molecule formaldehyde releaser that can function as a therapeutic tissue cross-linker for corneal and scleral applications. The present study was undertaken in order to study formulation factors using HPMC and SMG that could positively influence the cross-linking effect in these ocular tissues. Formulations containing 10 mM SMG and 100 mM sodium bicarbonate were prepared with varying HPMC concentrations from 0 to 4.4%. Their cross-linking effects on porcine and rabbit eyes were measured using differential scanning calorimetry (DSC), expressed as the change/difference in melting temperature (ΔTm) compared with the control. SMG in 4.4% HPMC solution resulted in ΔTm of 6.3 ± 1.21, while other concentration showed no differences in Tm shift on porcine cornea. In ex vivo rabbit cornea, there was a trend toward an increasing cross-linking effect with higher viscosity albeit mild differences. While a significant Tm shift was observed in porcine and rabbit sclera, there was no difference in effect of cross-linking between four HPMC concentrations. Increasing the HPMC concentration does not negatively affect the cross-linking efficacy attributed by SMG and could still be a positive cross-linking enhancer by virtue of increasing tissue contact time in a dynamic biological system. This information will be useful for planning further animal and human studies.
Output open‐circuit voltage control method with resistor–capacitor–diode dummy load branch for SSAS
Authors: Jin Shanshan , Zhang Donglai , Wang Chao , Wang Zicai , Zhang Hua , Zhu Hongyu 
Published: December 2019

The current output type space solar array simulator (SSAS) is an important test equipment for a spacecraft power supply to achieve high dynamic output response performance and meet the power current high precision requirements of the power conditioning unit (PCU). However, the current output type SSAS cannot produce a stable open circuit voltage when the output terminal is completely disconnected from the load. Therefore, it is impossible to reliably test the PCU with different architectures. In this study, the open circuit voltage control output problem is analysed, and a parallel resistor–capacitor–diode (RCD) dummy load branch in the SSAS output port is proposed to ensure that the SSAS outputs high‐precision open circuit voltage values and provides stable series switching performance without adversely affecting the shunt switching performance. The proposed solution yielded excellent experimental results for a 1 kW hardware power SSAS platform. The open circuit voltage control accuracy is 0.5%, and the series switching test and shunt switching test yielded stable performances with a high dynamic response that quickly converges to the target working points at 1.25 kHz switching frequency, indicating that the PCU can be reliably tested regardless of whether a series architecture or a shunt architecture is used.
La myopathie liée à PYROXD1: Caractérisation clinique, histologique, et génétique
Authors: Lornage Xavière , Romero Norma B. , Laporte Jocelyn , Böhm Johann 
Published: December 2019

Des mutations récessives dans le gène PYROXD1 ont été récemment décrites chez des patients présentant un tableau de myopathie congénitale ou de dystrophie musculaire des ceintures [1-4]. PYROXD1 (PYRidine nucleotide-disulfide OXidoreductase Domain-containing protein 1) est une protéine exprimée de manière ubiquitaire que l’on retrouve dans le cytosol et les noyaux des fibres musculaires squelettiques. La fonction précise de PYROXD1 est peu connue et des analyses de complémentation dans la levure suggèrent qu’il s’agit d’une oxido-réductase capable de prévenir les effets du stress oxydatif [3]. La diminution de l’expression de PYROXD1 est létale lors du développement chez la drosophile, et elle altère la prolifération, la migration, et la différentiation des myoblastes murins.
Cet article vise à résumer brièvement les caractéristiques cliniques, histologiques, et génétiques de la myopathie liée à PYROXD1 afin d’éclairer le mécanisme pathophysiologique de la maladie et d’analyser la corrélation entre génotype et phénotype.
Méthode automatisée d’analyse d’images appliquée à la dermatomyosite
Authors: Periou Baptiste , Amer Yasmine Baba , Authier François Jérôme 
Published: December 2019

L’analyse histologique du tissu musculaire est un élément déterminant pour le diagnostic et la compréhension physiopathologique des myopathies. Le développement d’outils numériques et informatiques permet des analyses d’images quantifiées à grande échelle applicable aux biopsies musculaires.
L’analyse d’images automatisée permet de déterminer la taille de l’ensemble des myofibres sur un échantillon de muscle et d’évaluer l’atrophie myocytaire. Le codage couleur selon la taille permet de visualiser directement la topographie de l’atrophie myocytaire. Cette approche morphométrique appliquée à la dermatomyosite permettra une meilleure stratification des patients.
Gherasim Luca-son double, son dé-z’écroué
Authors: Tigirlas Luminitza Claudepierre 
Published: December 2019

Titubant sur les mâts de l’imaginaire, Levée d’Écrou, prose poétique épistolaire de Gherasim Luca (1913–1994), narre la déliaison subjective dans un navire naufragé du lien social qui ne ferait pas nœud du fantasme pour le personnage. De manière joycienne, le corps de l’Anonyme & l’Inconnu lucaldien n’est rien d’autre que le Réel, l’essorage du « linge mouillé ». Le narrateur suggère un dialogue dans son style dé-monologique où l’aventure des mots maintient en boucle le Je, autrifié en occurrence. C’est un rite qui prend une fonction conjuratoire contre le danger de se rendre : « pire que fou - faux ». Le thaumaturge, Saint Gherasim le Kephalonite combat avec le Démon sonore tapi dans le Poète-Luca ayant choisi « un nom et un égarement». Fallait-il que l’etranjuif rompt la filiation de Locker, ce nom-lacune du père déifié et défié puisque non échappé à la guerre ? D’entendre le poème proféré L’autre Mister Smith conduit vers un questionnement : Gherasim Luca insiste-t-il de libérer sensuellement le son, de vaquer dans l’o-râl(e) de l’ironie mélancolique afin de s’extraire au nouage R.S.I. et assouvir son exigence de transmutation radicale ?
Therapie der renalen Anämie
Authors: Krüger Thilo 
Published: December 2019

ZUSAMMENFASSUNGDie renale Anämie gehört zu den wesentlichen Begleiterkrankungen von Patienten mit fortgeschrittener Nierenerkrankung. Somit sind die Diagnose und Therapie eine wesentliche Aufgabe des Nephrologen. Seit Zulassung von Epoetin hat sich dieses Feld enorm verbreitert und ist deutlich komplexer geworden. Dieser Artikel beschreibt pathophysiologische Zusammenhänge sowie die aktuellen Empfehlungen zur Therapie mittels Epoetin. Orale Antagonisten der HIF-Ph (Hypoxia-Inducible-Factor Prolylhydroxylase), auch HIF-Stabilisatoren genannt, können eine weitere wesentliche Neuerung in der Therapie der renalen Anämie darstellen. Diese neue, noch in Erprobung befindliche Substanzklasse wird im vorliegenden Beitrag ebenfalls vorgestellt und es wird über die bisherigen Erkenntnisse berichtet.
Aktueller Forschungsstand zur HIV-PrEP: HIV-Prävention und Verbreitung anderer STI
Authors: Bremer Viviane , Koppe Uwe , Marcus Ulrich , Jansen Klaus 
Published: December 2019

Zusammenfassung
Einleitung Eine Infektion mit HIV kann durch die Einnahme einer HIV-Prä-Expositions-Prophylaxe (PrEP) wirksam verhindert werden. Die Einnahme einer PrEP schützt allerdings nicht vor anderen sexuell übertragbaren Infektionen (STI).
Forschungsziele Ziel des vorliegenden Forschungsüberblicks ist die Beantwortung von zwei Fragenkomplexen: 1. Wie verbreitet ist die PrEP, und wie wirkt sie sich auf die HIV-Prävalenz aus? 2. Kommt es im Zuge der PrEP-Einnahme durch möglicherweise vermehrt kondomlosen Sex zu einem epidemiologisch relevanten Anstieg von anderen STI?
Methoden Es wurden eine Literaturrecherche zu Studien zu PrEP, HIV und anderen STI durchgeführt und Meldedaten aus den USA, Großbritannien und Australien sowie eigene Daten aus Deutschland analysiert.
Ergebnisse Sowohl aus den bisher publizierten Daten aus dem Ausland als auch den eigenen Daten aus Deutschland geht hervor, dass sich die PrEP als wirksame HIV-Prophylaxe v. a. unter MSM verbreitet. Gleichzeitig zeigen die Daten, dass es innerhalb der letzten Jahre zu einem starken Anstieg von STI-Diagnosen gekommen ist. Dieser ist jedoch bereits vor der Einführung der PrEP zu beobachten gewesen und geht wahrscheinlich sowohl auf einen Anstieg von kondomlosem Analsex unter MSM als auch auf vermehrte niedrigschwellige Testangebote zurück. Ein kausaler Einfluss der PrEP ist bislang nicht belegt.
Schlussfolgerung Die Prävention anderer STI muss verbessert werden. Verbesserte STI-Testung und Anbindung von PrEP-Nutzer*innen an das medizinische Versorgungssystem bieten die Möglichkeit, den Anstieg von STI wirksam zu begrenzen. Daher ist es wichtig, dass den PrEP-Nutzer*innen – aber nicht nur diesen – regelmäßige kostenlose STI-Tests inklusive Beratung zur Verfügung stehen, wie vom Terminservice- und Versorgungsgesetz (TSVG) seit der zweiten Jahreshälfte 2019 vorgesehen.