bluuebunny/crossref_metadata_2025_split huggingface dataset:
The demand for elderly care services and anticipated living arrangements among the oldest-old in China based on the Andersen model
Authors: Zeng Yanbing , Que Shuang , Lin Chenxi , Fang Ya 
Published: July 2020

Abstract
Background: In China, the issues arising from an aging population are becoming increasingly serious, so research on elderly health has become a topic of discussion. However, few studies have focused on the oldest-old with regards to their existing demand for elderly care services and anticipated living arrangements. Methods: The data of 4738 participants aged ≥80 years were extracted from the Chinese Longitudinal Health Longevity Survey (CLHLS) carried out in 2014. Using the Andersen model as the analysis framework, a multiple logistic regression was used to analyze the relationship between anticipated use of social services and intended residence and influencing factors. Odds ratios (ORs) were calculated to indicate the relationship between the influencing factors and the dependent variables.Results: From the descriptive analysis results, it is found that oldest-old showed high anticipated needs for care services, such as home visits (83.5%), health education (76.4%). And there exists a huge imbalance between supply and demand for aged care services. Moreover, living with children is still the most important way of providing for the oldest-old (44.4% in urban, 55.6% in rural). The multivariate regression results showed that the demand for elderly care services and anticipated living arrangements among the oldest-old in China are influenced by predisposing factors, enabling factors, and need factors (P<0.05). The oldest-old who are older, without housing property rights, childless, and ADL-restricted are more tend to live in long-term care institutions (ORs>1, P<0.05). Conclusions: The most vital needs of the oldest-old are home visits, health education, and spiritual comfort. There is a huge imbalance between supply and demand. Moreover, living with children is still the most important way of providing for the oldest-old. Demand for elderly care services and anticipated living arrangements are influenced by predisposing, enabling and need factors. Although the family plays an essential role in the healthcare of the oldest-old, the traditional pension model no longer meets the multi-level and diversified healthcare service needs of the oldest-old due to the rapidly aging Chinese population, which requires countermeasures from policy makers.
Expression of Spindle and Kinetochore-related Complex Subunit 3 is Associate With the Progression and Prognosis of Hepatocellular Carcinoma and Pancreatic Adenocarcinoma
Authors: Su Kuiwei , Huang Yu , Xie Shufang , Yang Chen , Ru Guoqing , He Xianglei , Chen Wanyuan , Pan Hongying , Cheng Gang , Wang Shibing 
Published: July 2020

Abstract
Background

Several studies have shown that Spindle and Kinetochore-related Complex Subunit 3 (SKA3) is closely related to the diagnosis and prognosis of various cancers. SKA3 plays a vital role in mitosis, but the mechanism underlying its action in tumors has not been fully elucidated.
Methods

Two separate microarrays of pancreatic adenocarcinoma (PAAD) and hepatocellular carcinoma (HCC) samples were downloaded from the Gene Expression Omnibus (GEO) and analyzed using R software. Tissues from 203 HCC and 321 PAAD patients were used for tissue microarray (TMA) construction and immunohistochemical staining for scoring. Kaplan-Meier estimators were used to determine their clinical relevance. Finally, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomics (KEGG) were used for analyzed rich pathways of SKA3 to understand gene function further.
Results

Contrary to the results obtained from the GEO database, HCC and PAAD tumor tissues exhibited significantly lower expression of SKA3 compared to the adjacent tissues (P < 0.001). The size of HCC tumor and Edmondson grade were statistically correlated with SKA3 expression (P < 0.05). No correlation was observed between the levels of SKA3 expression and vascular invasion, metastasis, or lymphatic infiltration in HCC patients. Moreover, factors related to decreases of SKA3 in PAAD could similarly not be found. Kaplan-Meier survival curves indicated that SKA3 upregulation in HCC was significantly associated with better prognosis (P = 0.016). In contrast, low levels of SKA3 were related to poor prognosis of PAAD patients (P = 0.026). Enrichment analysis of GO and KEGG pathways showed that SKA3 gene was closely related to cell cycle pathways.
Conclusions

The results of the present study indicate that SKA3 expression can serve as a diagnostic and prognostic biomarker for HCC and PAAD. However, there is a need to conduct further studies to verify these findings, especially the prognostic role of SKA3 in PAAD.
Association of cardiometabolic multimorbidity pattern with dietary factors among adults in South Korea
Authors: Jeong Dawoon , Kim Jieun , Lee Hansongyi , Kim Do-Yeon , Lim Hyunjung 
Published: July 2020

Abstract
Backgrounds

Globally, cardiometabolic multimorbidity pattern (CMP) is a complexed chronic health status which shorter the life expectancy compared with single disease in adults. We aimed to identify multimorbidity patterns in Korean adults to clarify the associations between dietary factors and CMP.

Methods

Nationally representative data for 9,011 Korean adults aged 19-64 years are obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) from 2013-2015. Multimorbidity patterns for CMP, inflammatory disease, cancer and other disease pattern were identified by exploratory factor analysis. Dietary factors including food, nutrient intake and diet habits were evaluated. Multivariable-adjusted logistic regression models examined the associations between dietary factors and CMP.

Results

More than half of the multimorbidity pattern was CMP (n=4,907, 54.5%); CMP subjects were more likely to be older, male, less educated, lower income, laborers, smokers, and high-risk consumers of alcohol than those of non-CMP subjects. A higher intake of calcium (OR= 0.809, 95% CI= 0.691-0.945), potassium (OR= 0.838, 95% CI= 0.704-0.998), and fruits (OR= 0.841, 95% CI= 0.736-0.960) were inversely associated with the prevalence of CMP while the consumption of irregular meals (OR=1.164, 95% CI= 1.034-1.312) and skipping breakfast (OR=1.279, 95% CI= 1.078-1.518) were associated with a 16% and 28% higher likelihood of CMP, respectively.

Conclusions

CMP accounts for more than half of the multimorbidity patterns in Korean population, and lower intake of calcium, potassium, fruits, and skipping meals might have strong associations with CMP.
Metabonomics Study on the Effect of Traditional Chinese Medicines Feed Addition on Growth Performance and Serum Metabolic Profile of Juvenile Chinese Softshell Turtle (Pelodiscus Sinensis Wiegmann) using UPLC–Triple /TOF–MS Analysis
Authors: Xiao Mingsong , Bao Fangyin , Wang Yuliang , Liu Huabin , He Jixiang 
Published: July 2020

Abstract
Background：Traditional Chinese medicines (TCMs) had been proven to stimulate digestion, promote growth, boost immune response, and reduce inflammatory potential in aquaculture, but its action mechanism was still lack of holistic interpretation. Results: The UPLC-Triple-TOF-MS/MS based platform was developed to investigate the serum metabolic profile associated with the growth performance and immunity in Pelodiscus sinensis fed with the diet added with TCMs feeding additive. The final weight and specific growth rate of TG2 groups was significantly the highest (p ˂ 0.05), and the feed conversion ratio of TG2 groups was significantly the lowest (p ˂ 0.05) compared to the CG group. In the metabolomics assay, a total of 795 (VIP > 1) out of 3089 variable ions were significantly different between the TG2 group and CG group. 43 potential biomarkers between TG2 and CG groups were finally screened out on the basis of VIP > 1 and p < 0.05. Based on the analysis of MetPA, eleven potential biomarkers and six involved metabolic pathways were significantly regulated with treatment of TCMs. Phenylalanine, tyrosine and tryptophan biosynthesis and Arginine and proline metabolism were the two most heavily affected pathways (Impact >0.2), while Tyrosine metabolism, Cysteine and methionine metabolism and Arginine biosynthesis were relatively lightly affected pathways. Conclusions：The dietary supplementation nineteen TCMs as feed additives could influence the growth performance of the healthy juvenile P. sinensis, and the optimal dose of TCMs for juvenile turtles was 2% TCMs. The UPLC-Triple-TOF-MS based metabonomics may be a useful tool for elucidating the efficacy and mechanism of complex TCM prescriptions.
HMGB1/TNFR1/NF-κB Axis in Prostate cancer: Clinical and Biological Correlation
Authors: Jung Ae Ryang , Kim Ga Eun , Kim Mee Young , Ha U-Syn , Hong Sung-Hoo , Lee Ji Youl , Kim Sae Woong , Park Yong Hyun 
Published: July 2020

Abstract
Background

High mobility group box 1 protein (HMGB1) is known to be associated with progression, metastasis, and poor prognosis of several solid tumors, but the role of HMGB1 in prostate cancer (PCa) has remained unclear. Thus, we aimed to evaluate the clinical significance and the biological mechanism of HMGB1 in PCa.
Methods

To explore the clinical significance of HMGB1 in PCa, we performed IHC analyses using paraffin-embedded tissues from patients with low-, intermediate-, and high-risk PCa and from patients with BPH. Biological role and mechanism of HMGB1 in PCa were analyzed using cell viability, cell cycle, Western blot analyses, proteome profiler antibody array, and co-immunoprecipitation assay.
Results

We showed that increases in the expression of HMGB1 correlated with an increased risk of aggressive PCa, and high expression of HMGB1 was associated with poor biochemical recurrence-free survival in a Korean cohort. The inhibition of HMGB1 expression significantly reduced cell proliferation and increased cell cycle arrest in the sub-G0 phase. It also inhibited the invasive capacity of PCa cells in vitro. The above processes were mediated through the binding with TNFR1, leading to tumor progression by activation of the NF-κB signaling pathway.
Conclusions

We identified that HMGB1 is a critical factor in the development and progression of PCa by regulating the HMGB1/TNFR1/NF-κB signaling pathway. HMGB1/TNFR1 could serve as a novel therapeutic target for improving PCa therapy.
Corticosteroid Therapy of Patients in ICU with Coronavirus Disease 2019(COVID-19): A Single-center, Retrospective, Observational study
Authors: Ruan Zhengshang , Wei Ming , Xuan Si , Qian Aihua , Liu Lijun , Xu Bin , Xu Jing , Jiang Jinjun , Ren Rongrong , Zheng Junhua 
Published: July 2020

Abstract
Background

In December 2019, Coronavirus Disease 2019(COVID-19)occurred in Wuhan, China. The disease is a rapidly spreading to the world. Corticosteroid therapy is used among critically ill patients with COVID-19, but value of corticosteroid therapy is uncertain.
Objective

To investigate the association of corticosteroid therapy on intubation rates.
Methods

This was a retrospective, single-center, observational study performed in ICU at Jin Yin-tan hospital, Wu Han, China. 102 patients with COVID-19 admitted to ICU from 2019.12.31 to 2020.03.31 were selected as the research objects. The clinical data were collected to analyze the general characteristics, clinical symptoms, blood test and corticosteroid therapy. The intubation rate between corticosteroid therapy and non-corticosteroid therapy was compared.
Results

Baseline characteristics of patients between corticosteroid therapy and non-corticosteroid therapy were similar.(p > 0.05). We found that there was no significant difference of intubation rate between corticosteroid therapy and non-corticosteroid(P = 0.575), but there was a significant difference in noninvasive ventilation time between the two groups(P = 0.02).
Conclusion

Corticosteroid therapy cannot reduce intubation rate in ICU patients with COVID-19.
Comparative Analysis of Mycobacterium Tuberculosis-Specific Antigens and T-Cell Mitogen-Stimulated Interferon Gamma Production in Hemodialysis Patients and Healthy Individuals
Authors: Park Heechul , Kim Ye Na , Park Sung-Bae , Kim Junseong , Lim Jaewon , Kim Jungho , Park Ji Young , Kim Sunghyun 
Published: July 2020

Abstract
Background: The incidence of Tuberculosis (TB) is higher in patients undergoing chronic hemodialysis than in the general population; further, both the incidence and development of active TB from latent TB infection (LTBI) are considerably higher in patients undergoing hemodialysis than in any other group. The QuantiFERON-TB Gold In-Tube (QFT-GIT) assay is one of the most commonly used interferon gamma (IFN-γ) release assays (IGRAs) currently. We aim to know T-cell function of hemodialysis patients and the possible QFT false negatives.Methods: In order to analyze the MTB-specific antigen-stimulated IFN-γ release in patients on hemodialysis, the QFT-GIT test was used in this study. A total of 84 hemodialysis patients and 52 healthy subjects were enrolled from Kosin University Gospel Hospital and Catholic University of Pusan, Busan, Republic of Korea; their whole blood samples were collected and used for the present study.Results: The positivity results of the IGRAs in hemodialysis patients and normal subjects were 34/84 (40.4%) and 4/52 (7.6%), respectively. The median value of MTB-specific antigen-stimulated IFN-γ in hemodialysis patients with LTBI and non-LTBI status in hemodialysis patients, healthy individuals were 1.85 IU/mL (4.44ng/mL) and 0.028 IU/mL (0.067 ng/mL) and 0.255 IU/mL (0.612 ng/mL) respectively. In addition, Of the 34 LTBI status in hemodialysis patients, 14 (41.2%) had T-cell mitogen-stimulated IFN-γ levels of 10 or less, and 20 (58.8%) had 10 or more T-cell mitogen-stimulated IFN-γ. Moreover, Of the 49 non-LTBI status in hemodialysis patients, 19 (38.8%) and 30 (61.2%) respectively. On the other hand, there was no low level of T-cell mitogen-stimulated IFN-γ in the healthy individuals.Conclusion: This reveals that T-cell function in hemodialysis patients was reduced as compared to the healthy individuals. Therefore, the cut-off value should be adjusted for the active TB high-risk group when using IGRA tests. The clinical manifestations of TB in patients on hemodialysis are quite non-specific, making timely diagnosis difficult, and delaying the initiation of curative treatment, delay being a major determinant of outcome.
Distribuição dos profissionais de contabilidade nas microrregiões brasileiras: uma análise econométrica-espacial
Authors: Aparecida dos Santos Zenatta Francine , Boschetti Adamczyk Willian 
Published: July 2020

Objetivo: Identificar os fatores socioeconômicos que influenciam a distribuição espacial dos profissionais de contabilidade nas microrregiões brasileiras.
Metodologia: Utiliza-se os microdados da Relação Anual de Informações Sociais (RAIS) de 2016, dados socioeconômicos do IBGE para produto per capita, densidade demográfica, número de empresas e organizações atuantes e o Índice de Desenvolvimento Humano Municipal de 2016 estimado pela FIRJAN. Os métodos quantitativos empregados para investigar o relacionamento entre as variáveis incluem métodos de análise exploratória espacial, como os testes de correlação espacial I de Moran. Aplica-se técnicas de regressão múltipla e regressão espacial, considerando como variável explicada a proporção de profissionais contábeis por microrregiões brasileiras.
Resultados: Os resultados obtidos apontam o IDHM como a variável mais explicativa para a presença de profissionais de contabilidade, além do número de estabelecimentos atuantes em uma região. Assim, a distribuição de profissionais contábeis é heterogênea em consequência da dependência espacial das variáveis.
Contribuições do Estudo: Incorpora os efeitos de dependência espacial a fim de identificar a contribuição individual de cada fator socioeconômico para a localização dos profissionais de contabilidade.
Comportamento das despesas orçamentárias durante o período eleitoral: uma análise em painel de dados nos municípios brasileiros
Authors: Crispim da Silva Gilberto , Alberton Luiz , Ferreira Celma Duque , Lopes Jorge Expedito de Gusmão 
Published: July 2020

Objetivo: A partir da lente de ciclo orçamentário político (COP), investigou-se o comportamento das despesas empenhadas, dos gastos com investimentos e captação de empréstimos em período eleitoral, nos municípios brasileiros com população igual ou superior a 50 mil habitantes, no período de 2000-2016, compreendendo 353 clusters e 6001 observações. Investigou-se também se esses municípios cumprem as exigências legais sobre o uso de recursos orçamentários em ano de eleição. O estudo foi motivado pela falta de consenso na literatura sobre o tema em questão.
Metodologia: Foram construídas quatro hipóteses de pesquisa para auxiliar na consecução dos objetivos propostos. Os dados foram coletados dos sites do IBGE, STE e STN. Os dados foram analisados por meio do método de dados em painel balanceado, agrupados por municípios e região, com aplicação de regressão tobit e testes de robustez de Hausman, Breusch-Pagan Lagrange e F de Chow. Esse método abrangeu intervalos de confiança em 99%, 77%, 79% e 84% de explicação de comportamento entre as variáveis.
Resultado: Os resultados apontam que não houve mudanças das despesas empenhadas antes, durante e após período eleitoral, independente de igualdades partidárias e eleições em dois turnos, diferente do resultado de alguns estudos. Já quanto aos gastos com investimentos e captação de empréstimos em período eleitoral, o estudo sugere aumento médio em 9% e 68% respectivamente, e isso é mais intenso quando há igualdade partidária entre governos municipais e estaduais, principalmente em processo de reeleição. Quanto ao cumprimento das exigências legais sobre uso de recursos orçamentários em ano eleitoral, o estudo indica que os governos locais não cumprem as exigências normativas.
Contribuições do estudo: Contribui para a literatura específica, porque apresenta resultados robustos sobre a falta de consenso existente no tema em questão, com também para futuras pesquisas envolvendo municípios com menor população e comparação entre regiões e países.
Transparência da prestação de contas dos gastos públicos nos governos municipais: um estudo de caso no Estado de Goiás
Authors: Ferreira Celma Duque , Crispim da Silva Gilberto , Rosa Fabricia Silva da , Luiz Alberton  
Published: July 2020

Objetivo: Identificar os municípios goianos que cumprem os dispositivos legais da Lei de Responsabilidade Fiscal (LRF), quanto a transparência das prestações de contas da gestão pública no período de janeiro de 2010 a dezembro de 2018.
Metodologia: Com características descritivas, o estudo realizou consultas em sites das prefeituras, Tribunais de Contas da União (TCU), Estados e Secretaria do Tesouro Nacional (STN). A coleta de dados foi realizada por meio de check-list construído com base nos dispositivos legais atuais, e correios eletrônicos aos responsáveis pela publicidade de cada município quando não encontrado os dados. O instrumento de análise utilizado foi a estatística descritiva, coeficiente de correlação de Pearson e Spearman e Qui-Quadrado (associação de Pearson).
Resultados: Concluiu-se que não há uniformidade da informações entre os municípios, apesar de transcorrido dezoito anos de promulgação da LRF; os municípios goianos cumprem parcialmente as exigências legais; há municípios que não possuem site próprio e não disponibilizam link de acesso ao portal da transparência em suas homepages; há municípios que não publicam os instrumentos de planejamento orçamentários (PPA, LDO e LOA), bem como a prestação de contas da realização da receita e execução das despesas orçamentárias. Em alguns casos, foi encontrado dificuldades na identificação do link no portal da transparência em suas homepages, e assim optou-se ao envio de e-mail aos responsáveis indagando sobre os resultados.
Contribuições: O estudo contribui para a gestão do governo do Estado de Goiás, motivo pelo qual financiou a pesquisa por meio da Fundação de Amparo à Pesquisa do Estado de Goiás (FAPEG); para a literatura específica, porque apresenta estudo empírico sobre regulações com mais de dezoito anos de vigência e fomenta discussão para futuras pesquisas.
Estratégias para a economia de impostos: o Caso da Udi Bolos
Authors: Borges Sabrina Rafaela Pereira , Soares Larissa Ribeiro 
Published: July 2020

Objetivo: O caso da Udi Bolos discute sobre o planejamento tributário e o melhor regime de tributação a ser adotado por uma empresa de pequeno porte.
Metodologia: Este caso utiliza conteúdos tributários e apresenta discussões sobre a evasão e elisão fiscal, evidenciando elementos de um dilema ético-contábil vivenciado por muitos negócios familiares.
Resultados: O empresário da Udi Bolo Sr. Marcelo em busca de diminuir os seus custos recebe duas opiniões divergentes de dois contadores: agir dentro da legalidade fiscal ou sonegar. Após uma análise cuidadosa, o proprietário percebeu que é possível com um bom planejamento tributário obter economias para o negócio dentro da legalidade.
Contribuições do Estudo: O presente caso estimula a reflexão crítica dos discentes sobre os regimes tributários com o intuito de reduzir a carga tributária paga por empresas, sendo útil para a aprendizagem de conceitos em disciplinas associadas à tributária e análise de custos. Além disso, são realizadas reflexões éticas sobre o papel do contador diante do fornecimento de informações e manipulação de dados econômico-financeiros.
Transparent public management under the law of fiscal responsibility: an analysis in the municipalities of the CRAJUBAR region in the period from 2012 to 2015
Authors: Antonio Rafael Valério de Oliveira  , Bruno Rodrigues Cabral  , Milton Jarbas Rodrigues Chagas  
Published: July 2020

Purpose: This study aimed to verify on the websites of the municipalities of Crato, Juazeiro do Norte and Barbalha (CRAJUBAR), whether information about public management was in compliance with the Fiscal Responsibility Law, Supplementary Law 131/2009 and Decree No. 7185/2010.
Methodology: Descriptive study with qualitative approach. The municipalities of the CRAJUBAR Region, located in southern Ceará, were analyzed. The data used for the analysis of this survey refer to the period from 2012 to 2015 concerning the fiscal management transparency instruments of LRF (Fiscal Responsibility Law) No. 101/2000 as well as January 2017 concerning Supplementary Law 131/2009 and Decree No. 7.185/ 2010. Data was collected through the electronic portals of each city office. Excel 2013 spreadsheet was used as a support tool to analyze the collected data.
Results: It was found that local managers of the surveyed municipalities do not fully comply with the publication in electronic media of the instruments relating to the fiscal management transparency, as regards the disclosure of detailed information in real time.
Contributions of the Study: The non-compliance with the analyzed legislation was found, entailing a verification of efficiency in the application of the legislation under analysis. Transparency disclosure is key in the management process. The study addresses the debate on public resource transparency in the Fiscal Responsibility Law and Supplementary Law 131/2009, in addition to presenting the discussion on resource management in municipalities in the State of Ceará.