bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of laboratory haemoconcentration measures with filling pressures obtained via pulmonary arterial pressure sensors in ambulatory heart failure patients
Authors: Almufleh Aws , Desai Akshay S. , Fay Renaud , Ferreira Joao Pedro , Buckley Leo F. , Mehra Mandeep R. , Rossignol Patrick , Zannad Faiez 
Published: April 2020

AimsLaboratory measures of haemoconcentration correlate with invasive haemodynamics and clinical outcomes in hospitalized heart failure (HF) patients. We aimed to determine the association between haemoconcentration and haemodynamic measures in ambulatory HF patients with implantable pulmonary arterial pressure (PAP) sensors.Methods and resultsWe reviewed ambulatory HF patients (n = 23) managed at the Brigham and Women's Hospital with implantable PAP sensors (CardioMEMS™, Abbott, Atlanta, GA, USA) who had sufficient data for serial haemodynamic–haemoconcentration correlation. The primary measures of interest were the absolute changes in haemoglobin and diastolic PAP at follow‐up compared to baseline values (obtained at implantation). In 23 patients (median age 64 years, 57% with HF with preserved ejection fraction), 518 paired laboratory–haemodynamic measurements were evaluated. At a median follow‐up of 27 (interquartile range 13–42) months, 17 (74%) patients had at least one hospitalization (59 total hospitalizations including 30 HF hospitalizations). For the population as a whole, diastolic PAP was negatively correlated with haemoglobin level (r = −0.09, P = 0.053). This negative correlation was more apparent when changes in haemoglobin and diastolic PAP were evaluated at the time of HF hospitalization compared to baseline values (r = −0.40, P = 0.029). The mean rise in diastolic PAP of 3.6 mmHg at HF hospitalization corresponded to a numerical decline of 0.6 g/dL in haemoglobin (P = 0.20).ConclusionChange in haemoglobin was correlated with change in diastolic PAP in ambulatory HF patients, especially at the time of HF hospitalization. These findings support the potential for investigation into the role of ambulatory monitoring of haemoglobin as an inexpensive, non‐invasive tool to guide de‐congestion strategies and potentially prevent HF hospitalizations.
Prolonged culture in aerobic environments alters Escherichia coli H2 production capacity
Authors: Rochman Nash D. , Raciti David , Takaesu Felipe , Sun Sean X. 
Published: April 2020

AbstractGrowing interest in renewable energy continues to motivate new work on microbial biohydrogen production and in particular utilizing Escherichia coli a well‐studied, facultative anaerobe. Here we characterize, for the first time the H2 production rate and capacity, of E coli isolates from the 50 000th generation of the Long‐Term Evolution Experiment. Under these reaction conditions, peak production rates near or above 5 mL per hour for 100 mL of LB media was established for the ancestral strains and batch efficiencies between 0.15 and 0.22 mL H2 produced per 1 mL lysogeny broth (LB) media were achieved. All 11 isolates studied, which had been aerobically cultured in minimal media since 1988, exhibited a decreased H2 production rate or capacity with many strains unable to grow under anaerobic conditions at all. The genomes of these strains have been sequenced and a preliminary analysis of the correlations between genotype and phenotype shows that mutations in gene ydjO are exclusively observed in the two isolates which produce H2, potentially suggesting a role for this gene in the maintenance of wild type metabolic pathways in the context of diverse mutational backgrounds. These results provide hints towards uncovering new genetic targets for the pursuit of bacterial strains with increased capacity for H2 production as well as a case study in speciation and the control of phenotypic switching.
Chromatographic analyses and unambiguous identification of atranol‐like secondary metabolites in oakmoss absolute
Authors: Chittiboyina Amar G. , Wang Mei , Avonto Cristina , Parcher Jon F. , Khan Ikhlas A. 
Published: April 2020

AbstractOakmoss is a commercially significant natural extract used in exotic perfumes, cosmetics, and other personal care products. Unfortunately, oakmoss absolutes and oils also contain atranol and chloroatranols, well‐known potent skin sensitizers, and hence, their levels in personal care products are regulated. To address the presence of these metabolites and unravel the similar metabolites in the oakmoss absolute, two independent analytical methods were developed. As a proof of concept, one commercial absolute oakmoss was analyzed with complementary, orthogonal LC/MS, GC/MS methods and further confirmed with MS2 experiments. Sixteen secondary metabolites, including atranols, were identified by both GC and LC analyses. Many of the identified components appear to be the precursors of the atranols or process artifacts. One atranol analog, in particular, isopropyl haematommate, was investigated extensively with electron ionization mass spectrometry to show that fragmentation spectra can be applied for the unambiguous identification of related compounds. An intriguing fragmentation pattern was observed for a typical α‐hydroxybenzoate, involving sequential loss of alkene, alkanol, water, or carbon monoxide. A similar fragmentation pattern has been observed with ESI; however, the loss of CO2 was dominant, while the loss of CO was most commonly observed with the EI system independent of substituents on the aromatic ring. The identification of these metabolites was further confirmed with pure standards. Even though many of these unique secondary metabolites are structurally similar to atranols, their skin sensitization potential is unknown; hence, the developed methods can serve as an effective tool to assess the overall quality of various oakmoss‐based products.
Impaired orthostatic heart rate recovery is associated with smaller thalamic volume: Results from The Irish Longitudinal Study on Aging (TILDA)
Authors: De Looze Céline , Williamson Wilby , Hirst Rebecca , O'Connor John , Knight Silvin , McCrory Cathal , Carey Daniel , Kenny Rose‐Anne 
Published: April 2020

AbstractThe thalamus is a central hub of the autonomic network and thalamic volume has been associated with high‐risk phenotypes for sudden cardiac death. Heart rate response to physiological stressors (e.g., standing) and the associated recovery patterns provide reliable indicators of both autonomic function and cardiovascular risk. Here we examine if thalamic volume may be a risk marker for impaired heart rate recovery in response to orthostatic challenge. The Irish Longitudinal Study on Aging involves a nationally representative sample of older individuals aged ≥50 years. Multimodal brain magnetic resonance imaging and orthostatic heart rate recovery were available for a cross‐sectional sample of 430 participants. Multivariable regression and linear mixed‐effects models were adjusted for head size, age, sex, education, body mass index, blood pressure, history of cardiovascular diseases and events, cardiovascular medication, diabetes mellitus, smoking, alcohol intake, timed up‐and‐go (a measure of physical frailty), physical exercise and depression. Smaller thalamic volume was associated with slower heart rate recovery (−1.4 bpm per 1 cm3 thalamic volume, 95% CI −2.01 to −0.82; p < .001). In multivariable analysis, participants with smaller thalamic volumes had a mean heart rate recovery −2.7 bpm slower than participants with larger thalamic volumes (95% CI −3.89 to −1.61; p < .001). Covariates associated with smaller thalamic volume included age, history of diabetes, and heavy alcohol consumption. Thalamic volume may be an indicator of the structural integrity of the central autonomic network. It may be a clinical biomarker for stratification of individuals at risk of autonomic dysfunction, cardiovascular events, and sudden cardiac death.
Effect of tongue‐strengthening exercises on tongue strength and swallowing‐related parameters in chronic radiation‐associated dysphagia
Authors: Van den Steen Leen , Baudelet Margot , Tomassen Peter , Bonte Katrien , De Bodt Marc , Van Nuffelen Gwen 
Published: April 2020

AbstractBackgroundRadiation‐associated dysphagia (RAD) is highly prevalent in head and neck cancer (HNC) patients, with insufficient tongue strength (TS) as a characteristic of this disabling complication. The effects of tongue‐strengthening exercises (TSE) on TS, swallowing, and quality of life (QoL) have not been studied in this population.MethodsA prospective phase 2 study using an 8 weeks during TSE protocol was carried out in 15 patients with chronic RAD. Outcome parameters were maximal isometric pressure (MIP), TS during swallowing (Pswal), swallowing function, and QoL. All parameters were evaluated at baseline, after 4 and 8 weeks of training, and 4 weeks after the last training session.ResultsMIP increased significantly, without detraining effects. Pswal did not increase significantly, but relevant effect sizes were measured. Swallowing function ameliorated, but did not result in increased functional oral intake, self‐reported outcome or QoL.ConclusionTSE in patients with RAD results in increased strength and swallowing function.
Access to a regular medical provider among head and neck cancer survivors
Authors: Massa Sean T. , Pipkorn Patrik , Jackson Ryan S. , Zevallos Jose P. , Mazul Angela L. 
Published: April 2020

AbstractBackgroundPatients with head and neck cancer (HNC) are at risk for limited healthcare access.MethodsIndividuals reporting a history of cancer were identified from the Medical Expenditure Panel Survey, an annual assessment of the nation's health. Access to care variables were compared between “HNC” and “other cancer” using multivariable methods and stratified by age 65.ResultsFrom 1998 to 2015, 420 patients with HNC and 14 468 with other cancers completed the survey. Among patients with HNC, 10.4% (95% confidence interval [CI] 5.0‐15.9) lacked a regular provider, compared to 6.1% (95% CI 5.5‐6.6) of other cancer survivors. Ten percent of HNC survivors lacked a regular provider and 14.6% report barriers to needed care. For those 65 years and older, HNC was associated with lacking a regular provider (adjusted odds ratio 2.58, 95% CI 1.15‐5.80).ConclusionHNC was associated with lack of a regular care provider after age 65, which may result in substandard survivorship care.
Metal‐Surface Interactions and Surface Heterogeneity in ‘Well‐Defined’ Silica‐Supported Alkene Metathesis Catalysts: Evidences and Consequences
Authors: Pucino Margherita , Liao Wei‐Chih , Chan Ka Wing , Lam Erwin , Schowner Roman , Zhizhko Pavel A. , Buchmeiser Michael R. , Copéret Christophe 
Published: April 2020

AbstractHere we present our observations on a peculiar kinetic behavior observed at low catalyst loadings for the metathesis of internal olefins on a highly active silica‐supported tungsten oxo alkylidene prepared through surface organometallic chemistry (SOMC). The observed kinetic profile is comprised of two consecutive regimes, which support the presence of two different active sites on the surface of such catalysts. We propose that the more active site is operational in the beginning of the reaction but deactivates very fast, and the second one initiates over time due to the presence of ethylene formed subsequently under the reaction conditions. A combination of spectroscopic techniques and computations was used to identify the possible nature of these sites. Solid‐state NMR, EXAFS and DFT calculations are consistent with the esence of two distinct surface species that likely originate from the occurrence of slightly different local environments on the surface, that is, metal sites with a different number of nearby siloxane bridges. This data highlights the effects that may arise from the amorphous nature of the supports like silica and the difficulties to obtain truly single‐site catalysts – one of the ultimate goals of SOMC.
Generalized differential quadrature analysis of unsteady three‐dimensional MHD radiating dissipative Casson fluid conveying tiny particles
Authors: Thumma Thirupathi , Wakif  Abderrahim , Animasaun Isaac Lare 
Published: April 2020

AbstractIt is worth remarking that little is known about generalized differential quadrature analysis of three‐dimensional flow of non‐Newtonian Casson fluid in the presence of Lorentz force, thermal radiation, haphazard motion of tiny particles, thermomigration of these tiny particles due to temperature gradient, heat source, significant conversion of kinetic energy into internal energy, first‐order chemical reaction, convectively heated horizontal wall, and zero nanoparticles mass flux at the stretching surface. The revised form of Buongiorno's nanofluid model accounted for significant influences of Brownian motion and thermophoresis. The similarity solution was complemented with a powerful collocation procedure based on the generalized differential quadrature method and Newton–Raphson iterative scheme to achieve accuracy and convergent outcomes. The numerical effects disclose that the Casson nanofluid parameter slows down the axial velocities in both directions. Also, the unsteadiness parameter tends to decline generally the temperature throughout the medium and decrease particularly the concentration profile away from the stretching surface. These examinations are applicable in the field of biomechanics, polymer processing, and for characterizing the cement slurries.
Mixed convection flow of a Maxwell nanofluid with Hall and ion‐slip impacts employing the spectral relaxation method
Authors: Ibrahim Wubshet , Anbessa Temesgen 
Published: April 2020

AbstractThis article investigates the Hall and ion‐slip impacts on the mixed convection flow of a Maxwell nanofluid over an expanding surface in a permeable medium. The impacts of Brownian movement and thermophoresis parameters, Soret, Dufour, viscous dissipation, chemical reaction, and suction parameters, are, moreover, considered. Using the similitude changes, the partial differential equations with regard to the momentum, energy, and concentration equations are transformed to an arrangement of nonlinear ordinary differential equations, which are handled numerically utilizing a spectral relaxation method (SRM). The impacts of noteworthy physical parameters on the velocities, thermal, and concentration distributions are investigated graphically. Moreover, the numerical values of skin‐friction coefficients, local Nusselt number, and Sherwood number for different values of the mixed convection parameter Deborah number Hall parameter ion‐slip parameter Dufour number (Du), and Soret number are computed and tabulated. It is discovered that ascent in Deborah number reduces both the stream and transverse velocity profiles, while the inverse pattern is seen with augmentation in the mixed convection parameter. In addition, inverse patterns of the stream and transverse velocity profiles are seen with expansion in magnetic, Hall, and ion‐slip parameters. Besides this, the temperature and concentration disseminations decline with augmentation in Dufour number and chemical reaction parameters, respectively. It is likewise seen that both the skin‐friction coefficients lessen with expansion in Deborah number, and they ascend with upgrade in blended convection and ion‐slip parameters, while the opposite condition is noticed with augmentation in Hall parameter. Furthermore, the reverse trends of local Nusselt and Sherwood numbers are discovered with expansion in the Dufour and Soret numbers.
Drug‐induced tics: An observational postmarketing study
Authors: Touafchia Davy , Montastruc François , Lapeyre‐Mestre Maryse , Rousseau Vanessa , Chebane Leila , Revet Alexis 
Published: April 2020

AbstractObjectivesWhile drug‐induced tics have been described, in particular with neuroleptics, psychostimulants, or anti‐epileptics, the strength and the direction of these associations are still debated. The aim of this study was to investigate the association between tics and drug exposure through a two‐step analysis in two pharmacovigilance databases.MethodsWe first performed a descriptive clinical analysis of cases registered in the French pharmacovigilance database (FPVD) from January 1985 to December 2018. We then performed a disproportionality analysis in VigiBase®, the WHO pharmacovigilance database, from January 1967 to June 2019, through the calculation of reporting odds ratio (ROR).ResultsThe drugs most frequently associated with tics in the FPVD were methylphenidate, lamotrigine, montelukast, tramadol, mirtazapine, venlafaxine, aripiprazole, and risperidone. In VigiBase®, we found a significant ROR with methylphenidate (ROR 37.54, 95% confidence interval [CI] 34.81–40.48), montelukast (ROR 12.18, 95% CI 10.29–14.41), aripiprazole (ROR 7.40, 95% CI 6.35–8.62), risperidone (ROR 4.40, 95% CI 3.72–5.21), and venlafaxine (ROR 1.52, 95% CI 1.14–2.03).ConclusionThis postmarketing study confirmed a potential harmful association with methylphenidate (the highest association, as expected), aripiprazole, risperidone, lamotrigine, and venlafaxine and, interestingly, found a strong signal with montelukast, which, to our knowledge, had never been published before.
The association between interleukin‐8 levels and the development of withdrawal symptoms during methamphetamine abstinence
Authors: Feng Liang , He Weilei , Lin Shasha , Ruan Yiting , Yuan Chengxiang , Qiu Huihua , Ren Wenwei , He Jincai 
Published: April 2020

AbstractObjectiveWithdrawal symptoms are common during methamphetamine (METH) abstinence. This study aimed to explore the association between serum interleukins and withdrawal symptoms during METH abstinence.MethodsThis study recruited 120 METH users, and 94 of them completed the 2‐week follow‐up. Serum interleukin‐1β, 6,8,10 were tested at admission. Withdrawal symptoms were assessed by the Methamphetamine Withdrawal Questionnaire (MAWQ).ResultsSerum IL‐8 levels were positively correlated with MAWQ scores at the 2‐week endpoint (r = .257, p = .013). The variation of the MAWQ scores during the 2‐week follow‐up was negatively correlated with serum IL‐8 levels at admission (r = −.249, p = .026). Serum IL‐8 levels remained associated with the severity of METH withdrawal symptoms (β = .363, p = .023), after adjusting for potential confounders.LimitationsThis study did not include normal controls. Most patients were male and cigarette smokers. Patients were only followed up for 2 weeks, and their toxicology data were not collected. Interleukins were only measured at admission, and were tested in serum, not in the cerebrospinal fluid.ConclusionsOur study demonstrated that higher serum IL‐8 levels may predict more severe withdrawal symptoms at 2 weeks after METH abstinence.
Conjunctive use of groundwater and surface water for paddy rice irrigation in Sanjiang plain, North‐East China*
Authors: Liu Jing , Chen Haorui 
Published: April 2020

AbstractMost of the paddy rice in the Sanjiang Plain is irrigated with groundwater. In recent years the water requirement has been increasing with the rapid spread of paddy fields, while the groundwater table is constantly falling. In order to maintain the sustainable development of water resources in the long term, comprehensive measures, including conjunctive use of surface and groundwater and water‐saving practices, should be jointly applied. To investigate these comprehensive measures, a study on the conjunctive use of groundwater and surface water for paddy rice irrigation has been ongoing since 2014. This paper presents water management scenarios based on the study by adopting various water‐saving irrigation technologies and measures, volume of reused water, and application of groundwater and surface water. A semi‐distributed water balance model was developed to simulate the water cycle at irrigation district level in order to analyse water productivity and groundwater dynamic response to various scenarios. Based on this study, reasonable water use modes under different hydrological years are proposed. These modes show how and when to use groundwater, surface water and return flow. Groundwater and surface water should be conjunctively used with groundwater as the main source for irrigation, surface water as an auxiliary source and reused water as a supplementary source. © 2020 John Wiley & Sons, Ltd.
Grayscale representation of infrared microscopy images by extended multiplicative signal correction for registration with histological images
Authors: Trukhan Stanislau , Tafintseva Valeria , Tøndel Kristin , Großerueschkamp Frederik , Mosig Axel , Kovalev Vassili , Gerwert Klaus , Kohler Achim 
Published: April 2020

AbstractFourier‐transform infrared (FTIR) microspectroscopy is rounding the corner to become a label‐free routine method for cancer diagnosis. In order to build infrared‐spectral based classifiers, infrared images need to be registered with Hematoxylin and Eosin (H&E) stained histological images. While FTIR images have a deep spectral domain with thousands of channels carrying chemical and scatter information, the H&E images have only three color channels for each pixel and carry mainly morphological information. Therefore, image representations of infrared images are needed that match the morphological information in H&E images. In this paper, we propose a novel approach for representation of FTIR images based on extended multiplicative signal correction highlighting morphological features that showed to correlate well with morphological information in H&E images. Based on the obtained representations, we developed a strategy for global‐to‐local image registration for FTIR images and H&E stained histological images of parallel tissue sections.
lncRNA Neat1 Stimulates Osteoclastogenesis Via Sponging miR-7
Authors: Zhang Yan , Chen Xiao-Feng , Li Jing , He Fang , Li Xu , Guo Yan 
Published: April 2020

ABSTRACT
Increasing evidence uncover the essential role of long noncoding RNA (lncRNAs) in bone metabolism and the association of lncRNA with genetic risk of osteoporosis. However, whether lncRNA nuclear paraspeckle assembly transcript 1 (Neat1) is involved remains largely unknown. In the present study, we found that Neat1 is induced by osteoclastic differentiation stimuli. Knockdown of Neat1 attenuates osteoclast formation whereas overexpression of Neat1 accelerates osteoclast formation. In vivo evidence showed that enhanced Neat1 expression stimulates osteoclastogenesis and reduces bone mass in mice. Mechanically, Neat1 competitively binds with microRNA 7 (miR-7) and blocks its function for regulating protein tyrosine kinase 2 (PTK2). Intergenic SNP rs12789028 acts as allele-specific long-range enhancer for NEAT1 via chromatin interactions. We establish for the first time that Neat1 plays an essential role in osteoclast differentiation, and provide genetic mechanism underlying the association of NEAT1 locus with osteoporosis risk. These results enrich the current knowledge of NEAT1 function, and uncover the potential of NEAT1 as a therapeutic target for osteoporosis. © 2020 American Society for Bone and Mineral Research.