bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Point-of-Care for INR Testing Compared to Standard Laboratory Methods at a Tertiary Care Hospital in Saudi Arabia
Authors: Bhat Manzoor , Abuzied Yacoub , Fagih Zahra , Wani Tariq , Gawan Ismael , Andalay El Mae , AlSheef Mohammed 
Published: August 2020

ABSTRACT

Introduction
Regular testing of the international normalized ratio (INR) is essential for people taking vitamin K antagonists as part of anticoagulation therapy. This study was undertaken to ascertain the efficacy of point-of-care testing (POCT)-INR versus conventional core laboratory testing in terms of result adequacy, waiting-time reduction, and patient satisfaction enhancement at the thrombosis clinic of the outpatient Medical Specialties Department in King Fahad Medical City, Saudi Arabia.

Methods
The study was conducted prospectively for 6 months (from June 2017 to December 2017) on 182 eligible participants out of 250 entitled patients who were attending the thrombosis clinic for warfarin dose adjustment and who fulfilled all the prerequisites for performing dual testing by fingerstick at the clinic and venipuncture by the core laboratory. The data-capturing template created on Microsoft Excel recorded turnaround times (TATs), clinical concordance of INR result variables by POCT, and laboratory methods. Individual patient experience was recorded to gauge satisfaction rate, and all the data were analyzed statistically.

Results
Of 182 patients included in the study, overall good concord was observed between POCT whole blood and laboratory plasma INR results with median bias of 0.07 and 92.3% agreement using acceptability criteria for clinical concordance of Clinical Laboratory Standards Institute (CLSI) 14-A and International Standards Organization (ISO) 17593-2007, respectively. Marked improvement in terms of patient's time spent at the clinic was noted, with substantial reduction from 180 to ∼30 minutes (p < 0.001). Survey questionnaire responses indicated that POCT of INR was highly convenient and enhanced patient experience in terms of shorter wait time, minimal invasive procedures, and immediate result availability (p < 0.001). Predominantly, participants (75.4%) endorsed and expressed a strong preference for the POCT procedure over conventional laboratory testing.

Conclusions
Whole blood INR testing for warfarin dose adjustment with validated POCT devices is adequately comparable to the core laboratory results. It also simplifies workflow steps at the thrombosis clinic, enhancing patient experience and convenience via the immediate availability of results, a less invasive procedure, and a marked reduction in waiting time. However, caution is needed with regard to higher INR results (≥4.7), which call for core laboratory confirmation.
Pengaruh Terapi Musik Dangdut Terhadap Tingkat Depresi Pada Orang Dengan Skizofrenia Di RSJD Dr. Arif Zainudin Surakarta
Authors: Kartina Irna , Kurniawan Adit , Sartikasari Febriana , Mustikarani Innez Karunia 
Published: August 2020

Schizophrenia is one of mental disorder which has negative effect on human brain and its cognitive function, perception, emotional, and behavior. In Indonesia the schizophrenia lead to the big number , almost touch 70% in population of people with mental illness. This study will investigate the impact of Dangdut Music Therapy among them, which were hospitalized in RSJD dr.Arif Zainudin Surakarta. This study used quantitative method with pre-experiment (without control )approach with pre-posttest applied, with total sampling 11 people with schizophrenia. The therapy were given in 4 time of intervention. Finding of this study was there were significant dissimilarity between pre-test and post test mean, P Value was 0.000. In conclusion, the Dangdut Music Therapy could be used as an alternative to treat depression on people with schizophrenia.
Keywords : Dangdut Music Therapy, Schizophrenia, Music Therapy, Depression.
Family Characteristics as Predictors of Youth Livelihood Outcomes in Kenya
Authors: Njuguna Christine W , Ngige Lucy W 
Published: August 2020

The purpose of the study was to investigate the effect of family characteristics on youth livelihood outcomes (YLO) in Kenya. A survey was conducted on a random sample of 201 respondents aged between 18 to 35 years who were selected from a list of members of registered self-help youth groups. Data was gathered through a questionnaire and analysed by the se of the Statistical Package for the Social Sciences (SPSS). Youth livelihood outcomes occurred along a continuum of three levels, namely: survival, security and growth livelihood levels. Results revealed that 52% of the respondents attained survival livelihood level, 18% attained the security level, and 30% attained the growth level of youth livelihood outcomes. Research findings indicated that family characteristics improved prediction power of youth livelihoods outcomes by 72.1% (R2 = 0.721; Log-Likelihood Ratio (χ2 = 203.18; d.f = 12; p = 0.000). The significant predictors of youth livelihood outcomes were the aggregate family income (β=1.00, p=0.000), paternal education (β = 1.60, p = 0.016), parental support (β = 1.93, p = 0.047), number of dependents (β = 0.02, p = 0.001), and aggregate family assets (β = 1.00, p = 0.019). However, family expenditure (χ2 = 2.37; d.f. = 2; p > 0.05) and maternal education (χ2 = 9.72; d.f. = 3; p > 0.05) had no statistically significant relationship with youth livelihood outcomes. These results implied that that youth from middle-income families, whose fathers had acquired higher levels of education, and whose families had fewer dependents, had accumulated family assets and whose parents supported their livelihood strategies attained higher levels of youth livelihood outcomes compared to their counterparts who were less privileged on similar family characteristics. The outcomes of this study may be used to develop appropriate family and youth-focused interventions to enhance youth livelihood outcomes.
Medullary thyroid carcinoma: consensus on diagnostic, management and treatment.
Authors: Morales Martín G , Rodríguez Padilla Á , Escoresca Suárez I 
Published: August 2020

Resumen

El carcinoma medular de tiroides es la tercera patología maligna tiroidea más frecuente. Tiene su origen en las células parafoliculares productoras de calcitonina y presenta una elevada prevalencia de enfermedad avanzada al diagnóstico. Puede presentarse de forma esporádica o familiar, con un 75% y 25% respectivamente: el screening genético del oncogen RET permite distinguir las dos formas.

La calcitonina es el marcador sérico específico y es el factor pronóstico más importante en la supervivencia y progresión de la enfermedad.

Aproximadamente el 30% de los pacientes con carcinoma medular presentan metástasis al diagnóstico. La identificación temprana de los portadores del oncogen RET y la tiroidectomía precoz es el tratamiento definitivo. La evaluación de los casos debe llevarse a cabo por un equipo multidiciplinar, siendo necesario la individualización de los fármacos y seguimiento de cada paciente.
Follow-up of differentiated thyroid cancer after surgery
Authors: Romero Lluch AR , Dueñas Disotuar S , Navarro González E 
Published: August 2020

Resumen

El carcinoma diferenciado de tiroides es una enfermedad cuya prevalencia va en aumento. Tras la cirugía, los pacientes van a requerir un seguimiento a largo plazo que debe ser personalizado en base al tipo de tumor, riesgo de recurrencia y respuesta al tratamiento. Realizar esquemas adecuados de seguimiento tiene una doble finalidad. En primer lugar, evitaremos un exceso de visitas y pruebas complementarias en pacientes que no se benefician de las mismas, optimizando así los recursos sanitarios y reduciendo el impacto emocional sobre la persona. Por otro lado, aquellos casos con enfermedad activa o con alto riesgo de recurrencia precisarán una vigilancia mucho más estrecha con pruebas complementarias frecuentes y secuenciales. En el presente artículo realizaremos una revisión pormenorizada del riesgo de mortalidad y de persistencia o recurrencia del cáncer diferenciado de tiroides, así como de las posibles respuestas al tratamiento (estratificación dinámica de riesgo) para finalmente establecer protocolos de seguimiento adaptados a cada situación clínica, con las mejores herramientas disponibles y buscando siempre el beneficio del paciente.
Is the intraoperative (PHT) determination still useful today?
Authors: Martínez Santos C , Martin Callejon G , Lucena Navarro F , Gándara Adán N 
Published: August 2020

Resumen

La determinación rápida intraoperatoria de hormona paratiroidea (PTHio) contribuyó a la transición de la exploración bilateral (EB) a la paratiroidectomia selectiva (PS) en la cirugía del hiperparatiroidismo primario (HPTP) esporádico para los casos con pruebas funcional y anatómica concordantes por su alta probabilidad de adenoma único. De esta forma, tras la exéresis dirigida de la glándula patológica con técnicas mínimamente invasivas, era posible detectar aquellos pocos casos en los que había más glándulas hiperfuncionantes (que requerirían una EB) y finalizar la cirugía en el resto.

Sin embargo, tras años de experiencia con la PTHio (con tiempos de respuesta largos en muchos centros) y la aparición de nuevas pruebas de localización preoperatoria más seguras como el CT-4D o el SPECT-CT, muchos cirujanos endocrinos realizan PS sin apoyo de PTHio precisamente cuando la posibilidad de tener localizado el adenoma único es muy alta.

Las indicaciones actuales de la PTHio se han reducido por tanto y han cambiado, siendo útil en casos en los que tradicionalmente no se usaba. Hoy por hoy, se recomienda en aquellos en los que hay más probabilidades de enfermedad multiglandular esporádica y se quiere realizar una PS en vez de una EB (p.e. si solo se dispone de una prueba de imagen positiva, las pruebas preoperatorias no son concordantes o en HPTP leve o normocalcémico) y en reintervenciones.
Jerusalém na perspectiva neotestamentária de Mateus
Authors: Nobre José Aguiar , Rufino Chaybom Anttone 
Published: August 2020

Jerusalém é a cidade da morada de Deus. É o arquétipo de toda cidade, cuja vocação universal à santidade se exterioriza. Isso já é evidente, de forma clara e objetiva pela sua própria história. Cidade que o rei Davi, segundo o coração de Deus, conquistou sem derramar sangue. É a cidade paradigmática em que o próprio Deus quis ser o seu Rei celeste. Contudo, aos poucos os seus interesses de poder vão se obscurecendo ante a grande luz do Salvador. Diante disso, indaga-se: face a uma cultura de morte, como lhe despertar para captar a Luz da Estrela (Mt 2,1-12)? Metodologicamente, trata-se de uma pesquisa bibliográfica. Cujo objetivo é reforçar que a Jerusalém celeste deve ser o sonho a ser buscado, preservado. Sabe-se que Jerusalém, quando não mais manifestou a sua verdadeira vocação, passou a ser vista como local de morte e oposição ao plano de Deus. Na conjuntura urbana hodierna, percebe-se que há também uma realidade de morte e violências desveladas que precisam ser banidas. A cidade que recebe os profetas enviados, cujas vozes foram silenciadas e as vidas ceifadas que precisa voltar a ser a morada de Deus nos seus filhos todos. Para tanto, os resultados esperados circunscrevem-se à fuga de toda forma de farisaísmo, casuística e legalismos que são sempre desprovidos de misericórdia. Na cidade celeste deverá favorecer a vida digna que brota da prática e regra de justiça inerente ao ser do discipulado. Sabe-se que sem justiça não há paz. Onde imperam os projetos de anti-vida, não há espaço para a verdade do Evangelho. Verdade que reivindicará sempre a sua efetivação.
A Study of Surgical Intervention in Fractures of Post-polio Residual Paralytic Lower Limb, Challenges Encountered, and Outcome Analysis
Authors: Raju Sivakumar , Singhi Prahalad Kumar , Thangamani Vinoth , Muthu Chidambaram 
Published: August 2020

ABSTRACT

Introduction
India is now a polio-free nation, but a huge load of ambulatory polio survivors present with challenging deformities and fractures to the present generation of orthopedic surgeons. These fractures are more challenging, because of the paralyzed, contracted shaft of femur fracture tissues, and inappropriate muscle forces, causing deformities. Also hypoplastic, osteoporotic, and less vascularized bone will influence the reduction maneuver, implant selection, fracture healing, and final outcome. We assess the outcome of surgical management of femoral and tibial fractures in the post-polio residual paralytic limb and the challenges encountered.

Materials and methods
Out of 22 cases with 23 fractures analyzed, 2 cases were lost to follow-up and hence excluded and the remaining 20 patients were analyzed. Pre-injury deformity, range of movement, mode of ambulation (Vignos scoring), mode of injury, surgical technique, rehabilitation, and outcomes were assessed.

Results
Minimum follow-up duration was 30 months; union was achieved by 18–24 weeks. We had one delayed union and one nonunion, which were managed with bone grafting. None of our patients had infection. A total of 16 patients regained their prefracture mobility; 4 patients developed hand to knee gait due to further weakness of the quadriceps muscle.

Conclusion
In our series, femur was the most commonly fractured bone among the post-polio residual paralytic limbs. Fractures don't heel as readily as in normal bone. Conservative treatment has guarded prognosis. Decision of surgical treatment will be challenging. Pre-injury state, surgical planning, technique, and implant choice will be key factors with appropriate rehabilitation to have a satisfactory outcome.
How to cite this article
Raju S, Singhi PK, Thangamani V, et al. A Study of Surgical intervention in Fractures of Post-polio Residual Paralytic Lower Limb, Challenges Encountered, and Outcome Analysis. J Orth Joint Surg 2020;2(1):10–16.
Avascular Necrosis of Metacarpal Head in an Amateur Volleyball Player: A Case Report
Authors: Raju Sivakumar , Singhi Prahalad Kumar , Somashekar Venkatappa , Kumar Raghava 
Published: August 2020

ABSTRACTAvascular necrosis of the metacarpal head is very rare compared to that of femoral head, talus, or scaphoid. Mauclaire disease also known as Dietrich's disease is a rare condition that refers to osteonecrosis of the metacarpal head. It can be multifactorial, usually associated with systemic lupus erythematosus (SLE), steroid use, or trauma. We present a case of 13-year-old boy, an amateur volleyball player presented with pain and swelling of the right index finger for 3 months. Initial X-rays were normal but subsequent X-rays revealed a mild flattening of the second metacarpal head; blood investigations were normal. The MRI revealed osteonecrosis with mild flattening of the second metacarpal head with synovial effusion. The patient was misdiagnosed as tuberculosis of the metacarpal head before presenting to us. The patient was treated conservatively with good functional outcome. Though several cases of Dietrich's disease have been reported in the literature but none in a volleyball player, just to stress that repeated microtrauma could also be an etiological factor and a rare differential diagnosis in patients with the painful metacarpophalangeal (MCP) joint. Most of the patients can be managed conservatively with good functional outcome. Curettage and bone grafting, transfer of metatarsal head, osteotomies, arthroplasty (excision or prosthesis), or arthrodesis have been described as various surgical means of treatment.How to cite this article:Singhi PK, Raju S, Somashekar V,et al. Avascular Necrosis of Metacarpal Head in an Amateur Volleyball Player: A Case Report. J Orth Joint Surg 2020;2(1):46–48.
Sustainable Irrigation through Renovation of Pond: A Case Study on Change of Crop Production, Irrigation, Cropping Pattern and Cropping Intensity Level in Sub Himalayan Terai Region of India
Authors: Das Ganesh , Saha Sankar , Rahman F. H. , Sarkar Surajit , Biswas Sujan , Hembram Sandip , Barman Prashanta , Sultana Samima , Roy Bikash , Ganguly Bablu 
Published: August 2020

Terai region of West Bengal fall under high rainfall region but 90% rainfall occurs in kharif season and drought observed during rabi season. NICRA project started in the Cooch Behar District during 2011. The project area and plan of work were selected on the basis of participatory rural appraisal method. The experimental trial was conducted from 2011 to 2019. The objective of the experiment was to development of sustainable irrigation system through renovation of pond and its impact on crop production. It was found from the study that pond renovation has potential impact on increasing crop yield, cropping intensity, copping system and area of irrigation.
The Use of Anticoagulants and Antiplatelet Agents among Outpatients in Alkharj
Authors: Ahmed Nehad J. 
Published: August 2020

Background: Thromboembolic diseases are a leading cause of mortality and morbidity worldwide. Anticoagulants and antiplatelet medications are important therapies in the prevention and treatment of cerebrovascular and cardiovascular diseases. There is a limited data about the prescribing of these medications.
Aim: This study aims to describe the pattern of anticoagulants and antiplatelet agents use among outpatients in Alkharj.
Methodology: This is a retrospective study that includes the electronic prescriptions among outpatients in a public hospital in Alkharj
Results: Aspirin was the most commonly prescribed agent (61.73%) followed by clopidogrel (18.60%) and enoxaparin (69%). Aspirin and clopidogrel was the most commonly prescribed combination (77.27%). Antiplatelet agents and anticoagulants result in improve several benefits but also could result in severe adverse effects and several drug interactions.
Conclusion: The prescribers should ensure that benefit of Antiplatelet and anticoagulant outweigh the bleeding risk before prescribing these medications. It is important also to implement educational interventions to improve their use.
Calretinin immunoreactivity in adrenal glands of developing, adult and ageing Sprague‐Dawley rats
Authors: Afework Mekbeb , Burnstock Geoffrey 
Published: July 2002

AbstractLocalization of calretinin immunoreactivity in the rat adrenal gland was studied using immunohistochemical methods. Calretinin‐immunoreactive adrenal chromaffin cells and nerve fibres were found at all of the ages examined from embryonic day 16 up to 2‐yr‐old. Immunoreactive chromaffin cells showed a decrease in number with increasing age, and in the adult and ageing rats they were found among the adrenaline‐storing chromaffin cells. Calretinin immunofluorescence was also observed in a few ganglion cells of the adult and ageing rats, and in most of the cortical cells at embryonic day 16. The density of immunoreactive nerve fibres in the gland showed a progressive increase with age to a peak by day 4 after birth and then a gradual decrease afterwards; they became associated mainly with some of the ganglion cells in the adult rat. As revealed by double labelling of calretinin immunoreactivity in adrenal sections from the adult rat with NADPH‐diaphorase histochemistry, no co‐localization existed between calretinin and NADPH‐diaphorase; however, a small number of neuronal cell bodies which contained nitric oxide synthase were found heavily surrounded with calretinin‐immunoreactive nerve fibres. In ageing rats, an increased density of calretinin‐immunoreactive nerve fibres was seen associated largely with the chromaffin cells.We conclude from this study that calretinin is found in the rat adrenal gland; the high degree of variability in its expression with age suggests that calretinin may be concerned with age‐related activities in the gland.
Amisulpride in dysthymia: results of a naturalistic study in general practice
Authors: Paes de Sousa M 
Published: July 2002

SummaryA naturalistic study was conducted in general practice in Portugal on the efficacy and tolerance of low doses of amisulpride in the treatment of dysthymia. A total of 109 patients received low doses (50 – 100 mg) of amisulpride for four weeks. A global evaluation showed good or very good efficacy and tolerance in more than 80% of the patients. The social disability observed at baseline was significantly improved after the four-week treatment period. Few adverse events were observed and only four patients dropped out due to side effects. Our results suggest that low doses of amisulpride might be a safe and effective treatment for dysthymia in clinical practice.
Couplings of Polarization with Interfacial Deep Trap and Schottky Interface Controlled Ferroelectric Memristive Switching
Authors: Chen Aiping , Zhang Wenrui , Dedon Liv R. , Chen Di , Khatkhatay Fauzia , MacManus‐Driscoll Judith L. , Wang Haiyan , Yarotski Dmitry , Chen Jun , Gao Xingsun , Martin Lane W. , Roelofs Andreas , Jia Quanxi 
Published: August 2020

AbstractMemristors with excellent scalability have the potential to revolutionize not only the field of information storage but also neuromorphic computing. Conventional metal oxides are widely used as resistive switching materials in memristors. Interface‐type memristors based on ferroelectric materials are emerging as alternatives in the development of high‐performance memory devices. A clear understanding of the switching mechanisms in this type of memristors, however, is still in its early stages. By comparing the bipolar switching in different systems, it is found that the switchable diode effect in ferroelectric memristors is controlled by polarization modulated Schottky barrier height and polarization coupled interfacial deep states trapping/detrapping. Using semiconductor theories with consideration of polarization effects, a phenomenological theory is developed to explain the current–voltage behavior at the metal/ferroelectric interface. These findings reveal the critical role of the interaction among polarization charges, interfacial defects, and Schottky interface in controlling ferroelectric resistive switching and offer the guidance to design ferroelectric memristors with enhanced performance.
Thermally Insulating Nanocellulose‐Based Materials
Authors: Apostolopoulou‐Kalkavoura Varvara , Munier Pierre , Bergström Lennart 
Published: August 2020

AbstractThermally insulating materials based on renewable nanomaterials such as nanocellulose could reduce the energy consumption and the environmental impact of the building sector. Recent reports of superinsulating cellulose nanomaterial (CNM)‐based aerogels and foams with significantly better heat transport properties than the commercially dominating materials, such as expanded polystyrene, polyurethane foams, and glass wool, have resulted in a rapidly increasing research activity. Herein, the fundamental basis of thermal conductivity of porous materials is described, and the anisotropic heat transfer properties of CNMs and films with aligned CNMs and the processing and structure of novel CNM‐based aerogels and foams with low thermal conductivities are presented and discussed. The extraordinarily low thermal conductivity of anisotropic porous architectures and multicomponent approaches are highlighted and related to the contributions of the Knudsen effect and phonon scattering.