bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytokine Storm in COVID-19 in Diabetic Patients: A Review
Authors: Mazumder Arpita , Roy Nilanjan 
Published: November 2020

COVID-19, a global pandemic has created a worldwide disaster since its first outbreak in December 2019 in Wuhan, China. Studies based in China have reported that people with diabetes and infected with COVID-19 showed higher hospital admission rates, serious pneumonia development, and higher mortality rates. SARS-CoV-2 can increase the metabolism of glucose by fueling immune cell overproduction - a phenomenon known as a 'cytokine storm'. Glucose metabolism is said to contribute to diverse COVID-19 outcomes. In this study, we are overviewing the linkage among SARS-CoV-2, diabetes, and cytokine storm for a better understanding of aggravating health conditions in diabetic patients due to this SARS-CoV-2 virus. In conclusion, this review will contribute to understanding complications that is rising among diabetic patients due to SARS-CoV-2 induced cytokine storm.
Bangladesh Journal of Infectious Diseases, October 2020;7(suppl_2):S46-S49
Spider diversity of Kerala University Campus, Thiruvananthapuram, Kerala, India
Authors: Asima A. , Prasad G. , Sudhikumar A.V. 
Published: November 2020

A study of spider diversity of Kerala University Campus, conducted for a period of four months revealed a total of 116 species of spiders belonging to 20 families. Among the families, Salticidae was found as the most common family and among the species Hersilia savignyi and Hippasa agelenoides were found as the most common species. Plexipus petersi, Plexipus pykulli, Xysticus minutes and Tibellus elongates were also noted as the commonly found spider species.
Identification of redgram resistant genotypes and morphological bases of resistance to pod fly, Melanagromyza obtusa (Malloch)
Authors: Kavitha Zadda , Vijayaraghavan C. 
Published: November 2020

Screening of 49 redgram genotypes conducted to identify pod fly resistant genotypes and morphological basis of resistance to pod fly revealed consistently resistance reaction of ICP 8864 (mean PSI 3.0) and VRG–59-1(mean PSI 3.3) to redgram pod fly. Pod length of various redgram germplasm ranged between 3.55 and 4.84 cm. Pod width ranged from 0.64 to 1.28 cm. Pod wall thickness ranged from 0.21 to 0.43 mm. Trichome density ranged between 302 and 375 per 9 mm2. Redgram pod width was the important morphological factor that influenced the redgram pod fly seed damage to a tune of 34.2 per cent. Pod length and width were positively correlated with the redgram pod fly seed damage while pod wall thickness and trichome density were negatively correlated. However, relationship between pod width and seed damage only was found to be significantly positive and rest of the morphological factors were not significant.
Moringa oleifera Alkaloids Inhibited PC3 Cells Growth and Migration Through the COX-2 Mediated Wnt/β-Catenin Signaling Pathway
Authors: Xie Jing , Luo Feng-xian , Shi Chong-ying , Jiang Wei-wei , Qian Ying-yan , Yang Ming-rong , Song Shuang , Dai Tian-yi , Peng Lei , Gao Xiao-yu , Tao Liang , Tian Yang , Sheng Jun 
Published: November 2020

Moringa oleifera Lam. (M. oleifera) is valuable plant distributed in many tropical and subtropical countries. It has a number of medicinal uses and is highly nutritious. M. oleifera has been shown to inhibit tumor cell growth, but this effect has not been demonstrated on prostate cancer cells. In this study, we evaluated the inhibitory effect of M. oleifera alkaloids (MOA) on proliferation and migration of PC3 human prostate cancer cells in vitro and in vivo. Furthermore, we elucidated the mechanism of these effects. The results showed that MOA inhibited proliferation of PC3 cells and induced apoptosis and cell cycle arrest. Furthermore, MOA suppressed PC3 cell migration and inhibited the expression of matrix metalloproteinases (MMP)-9. In addition, MOA significantly downregulated the expression of cyclooxygenase 2 (COX-2), β-catenin, phosphorylated glycogen synthase 3β, and vascular endothelial growth factor, and suppressed production of prostaglandin E2 (PGE2). Furthermore, FH535 (β-catenin inhibitor) and MOA reversed PGE2-induced PC3 cell proliferation and migration, and the effects of MOA and FH535 were not additive. In vivo experiments showed that MOA (150 mg/kg) significantly inhibited growth of xenograft tumors in mice, and significantly reduced the protein expression levels of COX-2 and β-catenin in tumor tissues. These results indicate that MOA inhibits the proliferation and migration, and induces apoptosis and cell cycle arrest of PC3 cells. Additionally, MOA inhibits the proliferation and migration of PC3 cells through suppression of the COX-2 mediated Wnt/β-catenin signaling pathway.
Pharmacoeconomic Evaluation of Cancer Biosimilars Worldwide: A Systematic Review
Authors: Huang Hui-Yao , Liu Cheng-Cheng , Yu Yue , Wang Le , Wu Da-Wei , Guo Lan-Wei , Wang Shu-Hang , Fang Hong , Bai Ying , Fang Yuan , Fan Qi , Sun Chao , Wu Ying , Shi Ju-Fang , Ma Fei , Tang Yu , Dai Min , Li Ning 
Published: November 2020

Background and Purpose: The availability of oncology biosimilars is deemed as a fundamental strategy to achieve sustainable health care. However, there is scarce systematic evidence on economic effectiveness of cancer biosimilars. We aimed to synthesize evidence from pharmacoeconomic evaluation of oncology biosimilars globally, provide essential data and methodological reference for involved stakeholders.Materials and Methods: This systematic review was conducted in PubMed, embase, the Cochrane library, CRD, ISPOR and NICE utill December 31, 2019. Information on basic characteristics, evaluation methodology and results were extracted. Quality of included studies was assessed using the Consolidated Health Economic Evaluation Reporting Standards Checklist.Results: For 17 studies identified (13 from Europe and four from United States), the overall quality was generally acceptable. A total of seven biological molecules involved with filgrastim, EPOETIN α, and trastuzumab leading the three. The mostly common evaluation perspective was payer, but the time horizon varied greatly. There were ten studies which adopted cost minimization analysis to evaluate efficiency while seven studies adopted budget impact analysis to address affordability, with cost ratio and cost saving being its corresponding primary endpoint. Although the comparability of included studies was limited and specific results were largely affected by uptake and price discount rates of the oncology biosimilar, the comprehensive results consistently favored its promotion.Conclusion: Globally, the economic evaluation of cancer biosimilars is in its initial phase. However, limited evidence from developed countries consistently supported both cost-effectiveness of efficiency and affordability of oncology biosimilars, while they were largely affected by uptake and price discount rate.
Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer
Authors: Huang Jia-Rong , Wang Sheng-Te , Wei Meng-Ning , Liu Kun , Fu Jing-Wen , Xing Zi-Hao , Shi Zhi 
Published: November 2020

Colorectal cancer is one of the most common and lethal cancers in the world. An important causative factor of colorectal cancer is ulcerative colitis. In this study, we investigated the therapeutic effects of piperlongumine (PL) on the dextran sulfate sodium (DSS)-induced acute colitis and azoxymethane (AOM)/DSS-induced colorectal cancer mouse models. Our results showed that PL could inhibit the inflammation of DSS-induced mouse colitis and reduce the number of large neoplasms (diameter &gt;2 mm) of AOM/DSS-induced mouse colorectal cancer by downregulation of proinflammatory cytokines cyclooxygenase-2 and interleukin-6 and epithelial-mesenchymal transition-related factors, β-catenin, and snail expressions, but fail to improve the colitis symptoms and to decrease the incidence of colonic neoplasms and the number of small neoplasms (diameter &lt;2 mm). These data suggested that PL might be an effective agent in treating colitis and colorectal cancer.
Safety and Efficacy of Adjunctive Therapy With Artesunate in the Treatment of Severe Malaria: A Systematic Review and Meta-Analysis
Authors: Zou Yuanyuan , Tuo Fei , Zhang Zhiqi , Guo Jiawen , Yuan Yueming , Zhang Hongying , Xu Zhiyong , Pan Ziyi , Tang Yexiao , Deng Changsheng , Julie Nadia , Wu Wanting , Guo Wenfeng , Li Changqing , Huang Xinan , Xu Qin , Song Jianping , Wang Qi 
Published: November 2020

Objective: The purpose of this meta-analysis of longitudinal studies is to determine the safety and efficacy of artesunate combined with other forms of adjunctive therapies for severe malaria.Methods: Following the PRISMA guidelines, we searched multiple databases with the search terms “artesunate” and “adjunctive therapy” and “severe malaria” in July 2020. If the search showed a randomized controlled trial, the study was included in this meta-analysis. The random-effects model was used to calculate the combined incidence rate and relative risk or risk difference.Results: This meta-analysis included nine longitudinal studies with 724 participants. We found that the mortality rates in the artesunate monotherapy group and the artesunate + adjuvant therapy group are similar (RD = −0.02, 95% confidence interval: −0.06–0.02). The incidence of adverse reactions in the artesunate monotherapy group and the artesunate + adjuvant therapy group was also similar.Conclusion: No significant differences in safety and efficacy were observed between the artesunate monotherapy group and the artesunate + adjuvant therapy group. Higher quality and rigorously designed randomized controlled studies are needed to validate our findings.
Por um Novo Renascimento: Leonardo da Vinci como símbolo da cultura humanista e técnico-científica
Authors: Marramao Giacomo , Aranovich Patricia 
Published: November 2020

Aula magna na XVIII International Philosophy Olympiad, em Roma, no dia 16 de maio de 2019. Essa aula foi pronunciada diante de jovens filósofos provenientes de oitenta países.
Tradução para o português de Patrícia Aranovich.
In-Vitro study of the Anticoagulant Property of Terminalia Catappa (Talisay) Leaf Extract Using Gallus Gallus (Chicken) Blood
Authors: Borela Vandon T. , Balunsat Klim Angelo L. , Briones Alyssa Juliana L. , Briones Patricia Nicole P. 
Published: November 2020

Prothrombin time is a test used to help detect and diagnose a bleeding disorder or excessive clotting disorder. It is important to know the prothrombin time because it checks to see if five different blood clotting factors are present. Lack of Vitamin K and having Liver problems are one of the factors that can decrease the prothrombin time of the blood. This research aims to investigate the potential ability of the Terminalia catappa (Talisay) leaf extract to increases prothrombin time of chicken’s blood. The research methods used by the researchers is experimental. A research design where the results are being observed and determined when the independent variable took effect on the dependent variable. . The materials used are ethanol, calcium chloride, leaves and chicken blood. The method that was used in the study is in-vitro, a process that is performed in a test tube, or elsewhere outside a living organism. The 0.5 ml plasma sample was separated into four tubes and the first group of plasma was tested first to determine the initial prothrombin time while the other three groups with the different volumes of plant extract (0.2, 0.4, 0.6 mg/ml) was added separately. The tubes were tilted at about 45° until the permanent clots was obtained. These are recorded as the prothrombin time. The research showed that the Terminalia Catappa leaf extract is effective on increasing the normal prothrombin time of the blood.
Athletic Trainers' Job Tasks and Status During the COVID-19 Pandemic: A Preliminary Analysis
Authors: Winkelmann Zachary K. , Games Kenneth E. 
Published: November 2020

Context
In December 2019, severe acute respiratory syndrome coronavirus 2, also known as the novel coronavirus disease 2019 (COVID-19), became a global public health crisis. Government officials in the United States subsequently responded by issuing lockdown orders that closed schools, terminated sports, and resulted in many people transitioning to working from home, immediately affecting the ability of athletic trainers (ATs) to practice clinically.

Objective
To describe the job status, job duties, telemedicine use, and resiliency of ATs during the COVID-19 pandemic.

Design
Cross-sectional study.

Setting
Mixed-methods survey.

Patients or Other Participants
A total of 611 ATs (age = 32 ± 13 years).

Main Outcome Measure(s)
The survey consisted of 6 demographic questions, a job status assessment (3 questions, 1 open-ended prompt), a telemedicine use assessment (5 questions, 2 open-ended prompts), and the 6-item Brief Resilience Scale. Qualitative analyses were completed using Text iQ technology and descriptive statistics, and cross-tabulations were conducted using follow-up χ2 comparisons of resiliency with job setting and telemedicine use.

Results
Most ATs continued to work in some capacity throughout the COVID-19 pandemic and expressed optimism about the likelihood that their job status and setting would return. However, participants shared financial and mental health concerns because of reduced pay, stress, and uncertainty about the future. We also identified versatility within the profession, as ATs were serving in new roles related to COVID-19 or adopting telemedicine (n = 251, 41.1%). Athletic trainers were implementing all domains of clinical practice using telemedicine, yet most did not consult legal counsel on or have formal training in the delivery method before implementation. Finally, most ATs exhibited normal resilience that was not affected by job setting (χ2 = 26.901, P = .68) or the use of virtual health care (χ2 = 2.597, P = .27).

Conclusions
The COVID-19 pandemic has affected ATs' jobs, and in many cases, the ATs have demonstrated adaptability and value in assuming various roles in the larger health care system.
Indigenous Peoples, Poverty and the Role of Social Workers
Authors: Suradi Suradi , Nulhaqim Soni Akmad , Mulyana Nandang , Suharto Edi 
Published: November 2020

Indigenous peoples were placed as second-class citizens, that have fallen behind in all aspects of life than any other citizen. In fact, indigenous people in any country has gained international legal protection through 'the United Nations Declaration the Right of Indigenous People' since 2007. In the entity, within the indigenous peoples, including women and children. The form of response to the declaration, each country develop policies in the form of regulation and followed by action programs targeting indigenous peoples. It has been over 10 years of the declaration proclaimed, but the indigenous peoples still face a lot of problems in the social, cultural, economic, political, legal, land and natural resources; not even the women and their children. This situation requires the presence of a social work profession, in which the role of professional help to acquire rights, improve the quality of life and well-being of indigenous peoples.
Keywords: indigenous peoples, poverty, social worker.
THE EFFECTS OF MUSIC INTERVENTION ON WOMEN’S ANXIETY BEFORE AND AFTER CESAREAN DELIVERY: A Randomized Controlled Trial
Authors: Denney Jeff M , Blackburn Karen L. , Bleach Courtney C. , Martinez Anibal R. , Bromley Philips Jennifer , Lanier Kristi , Dean Laura , Mertz Heather 
Published: November 2020

ABSTRACT:Objective: To assess effect of perioperative music intervention on maternal anxiety levels, physiologic metrics, and medication use for anxiety, nausea and pain during and after scheduled cesarean section. Methods: Women assigned to music intervention group were compared against controls. Physiologic metrics, medication requirements, and STAI scores were assessed for all participants. Results: 50 women were enrolled, assigned to either music intervention (n=25) or control (n=25) and analyzed. Physiologic metrics were similar between groups. Antiemetic, anxiolytic, and analgesic medication use intraoperatively and postoperatively were not significantly different. State and Trait scores by the STAI did not vary significantly by intervention (p=0.09). STAI scores before and after procedure demonstrated the least change for the intervention group (r=0.6) when compared to controls (r=0.2; p<0.05).Conclusion: Contrary to studies with formal music therapy, our data do not support use of patient-selected music as an intervention to reduce maternal anxiety or need for analgesics, anxiolytics, or antiemetics with scheduled cesarean section.
The Future of Hospital Sound: Transforming Healthcare Through Sound Experience
Authors: Sen Yoko Kamitani , Sen Avery 
Published: November 2020

Several years ago, a classically trained electronic musician got sick and spent many hours in hospitals. Being a musician, sensitive to sound, she was disturbed by the noise around her: people talking and screaming, doors getting slammed, phones and pagers ringing non-stop, overhead speakers announcing emergencies… and the cacophony of alarms beeping in the dissonance of tritones. Since then, she and her husband (co-author and innovation policy researcher) have embarked on a mission to transform sound experience in hospitals, in collaboration with Johns Hopkins Sibley Memorial Hospital, Stanford Medicine X, TEDMED, and medical device companies. When we listen to people talking about sound, their stories are always more than about sound; they reveal what it means to be a human during the most vulnerable times of their lives. In this article, we explore noise as a symptom of culture, how sound reveals the importance of caring for caregivers, the future of auditory alarm design, and the aesthetic realm in palliative care. These perspectives result from a human-centric (rather than technology-centric) approach to innovation, and how transforming the sound of healthcare means focusing on people and their experiences.
Can Rhythmic Sensory Stimulation Decrease Cognitive Decline in Alzheimer's Disease?: A Clinical Case Study
Authors: Clements-Cortes Amy , Bartel Lee , Ahonen Heidi , Freedman Morris , Evans Michael , Tang-Wai David 
Published: November 2020

Background/Objectives: To present Rhythmic Sensory Stimulation (RSS) as a potential new treatment of Alzheimer’s disease (AD).Design: Longitudinal case study over a three year period.Setting: RSS was provided both in a long-term care/research facility and in-home.Participant: One 92 year old female with AD.Intervention: Treatments consisted of RSS resulting in gamma frequency entrainment, provided by two different treatment devices over three years.Measurements: Quantitative and qualitative measures were used including: MMSE, SLUMS, interviews, observation notes and a participant question sheet.Results: MMSE scores since diagnosis three years earlier, as well as cognition, clarity, and awareness were reported by the case’s husband to have remained unchanged.Conclusion: Although further research is warranted, this case suggests that RSS has potential to help maintain cognition in AD.
Truth, Nature, and Sellars's Myth of the Given
Authors: Cahoone Lawrence 
Published: November 2020

ABSTRACT
When a philosopher and a dog play Frisbee, do they cognize the same Frisbee? Is Fido subject to the “myth of the given”? The questions are not silly, for as Marjorie Grene quipped, “Epistemology is a branch of ethology.” What follows accepts what is usually called a “correspondence” theory of truth and a “realist” account of human knowledge. Nothing new, but what will be distinctive is that it seeks to exploit an unusual naturalism deriving from the American philosophical tradition. It will particularly address the epistemic relation of sensing to knowing. A currently widespread view among those who object to realism can be traced to Wilfrid Sellars's 1956 critique of the “myth of the given.” Sellars argued that the normative “order of reasons” in which beliefs are adjudicated is discontinuous with the causal order of sensation or perception, so the former cannot be grounded in the latter. My claim will be that Sellars was half wrong, and the wrong half can be addressed by contemporary cognitive science and anthropology. The permission to employ the latter is granted by a special version of naturalism, “ordinal naturalism,” formed from the American philosophical tradition.
Restoration of old Auckland Customhouse
Authors: Boardman P. R. 
Published: November 2020

This building was built in 1890 and designed by Thomas Mahoney, who, with his father William, was also responsible for the Auckland City Art Gallery.
It was occupied until the early 1970’s by several government departments in addition to the Customs Department and this explains the cellular construction. There are three reasonably distinct areas on each floor.
Oplegging van bestuurlijke boetes aan overheden door de privacytoezichthouder
Authors: Duijkersloot Ton 
Published: November 2020

Oplegging van bestuurlijke boetes aan overheden door de privacytoezichthouder
In deze bijdrage staat centraal de oplegging van bestuurlijk boetes aan overheden, in het bijzonder door de privacytoezichthouder: welke mogelijkheden en beperkingen kent het Nederlands recht hiervoor in algemene zin, welke mogelijkheden en beperkingen golden en gelden in het bijzonder voor de Nederlandse privacytoezichthouder en in hoeverre heeft deze toezichthouder in het recente en verdere verleden boetes aan overheden opgelegd.
Komt het zwijgrecht alleen toe aan formele bestuurders?
Authors: Stijnen Rogier 
Published: November 2020

Komt het zwijgrecht alleen toe aan formele bestuurders? ABRvS 28 augustus 2019, ECLI:NL:RVS:2019:2952 (zwijgrecht)
In de voorliggende zaak, waarin een boete is opgelegd vanwege het niet in overeenstemming met het werkplan op een veilige wijze verwijderen van asbest, meende de onderneming dat aan haar voorman de cautie had moeten worden gegeven omdat hij leiding gaf aan de werkzaamheden. De Afdeling houdt echter vast aan haar rechtspraak dat het zwijgrecht van een rechtspersoon uitsluitend toekomt aan haar bestuurders. Mocht de voorman zelf worden beboet als feitelijk leidinggever of als normadressaat, dan zouden zijn verklaringen alleen uitgesloten hoeven te worden van het bewijs tegen hem.
Respect, Inherent Value, Subjects-of-a-Life Some. Reflections on the Key Concepts of Tom Regan’s Animal Ethics
Authors: Allegri Francesco 
Published: November 2020

This article reconstructs the theoretical premises of Tom Regan’s animal ethics, the American philosopher recently disappeared who has given a fundamental contribution to this area of practical ethics, by developing a theory of rights based on the extension to all subjects-of-a-life of Kantian notions such as inherent value and respect. Regan’s theory still remains the most rigorous foundation of an animal ethics alternative to the utilitarian approach of Peter Singer, but it is not without unresolved problems or not entirely satisfactory solutions. To remedy some of them, in the final part the author tries to insert into the Reganian theoretical framework elements of gradualism.