bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Digital Marketing Terhadap Peningkatan Kinerja dan impelementasi Artificial Intelligence (study kasus: PT.Akadia Digital Media)
Authors: Hidayat Ahmad Ridho , Ulum Miftahul , Irianti Nana Novia 
Published: December 2024

Berkembangnya teknologi dalam dunia bisnis berdampak pada perkembangan bisnis, baik dalam pemasaran secara digital maupun penggunaan kecerdasan buatan (AI), penggunaan teknologi yang maksimal akan berimbas pada peningkatan efisiensi dan efektifitas pada perusahaan. Penelitian ini dilatarbelakangi bagaimana pengaruh digital marketing terhadap peningkatan kinerja di PT.Akadia Digital Media. Kecerdasan Buatan yang dalam bahasa Inggris disebut Artificial Intelligence (AI) adalah salah satu konsep teknologi informasi dari cabang ilmu komputer dalam meniru kecerdasan manusia. Marketing Artificial Intelligence (AIM) adalah gagasan yang menggabungkan kecerdasan buatan (AI) dengan strategi pemasaran untuk meningkatkan efektivitas, akurasi, dan efisiensi pemasaran secara keseluruhan. Dengan mengintegrasikan AI ke dalam strategi pemasaran, AIM dapat menawarkan berbagai keuntungan bagi perusahaan. Tujuan penalitian ini melihat pengaruh digital marketing terhadap peningkatan kinerja. Mengunakan metode kualitatif metode regersi dinamis Partial Adjustment Model (PAM) dan analisis dinamis dengan model penyesuaian parsial Nerlove dan metode kedua menggunakan metode Systematic Literature Review (SLR). Penelitian menganalisis pengaruh digital marketing terhadap peningkatan kinerja dan peran Artificial Intelligence dalam industri media. AI dapat digunakan untuk memahami audiens target, membuat konten pemasaran lebih relevan, dan membantu memahami perilaku dan preferensi konsumen dengan data dan analisis. Penelitian ini bertujuan untuk menentukan bagaimana AI akan membentuk masa depan pemasaran yang lebih cerdas, efisien, dan efektif.
Anteseden dan Konsekuensi Kinerja Pegawai Pengadilan Tata Usaha Negara Gorontalo
Authors: Suja’i Ahmad , Fikri Amir , Sultan Zulkifli 
Published: December 2024

Tujuan penelitian ini adalah untuk menguji pengaruh disiplin dan kompetensi terhadap kinerja pegawai dengan motivasi sebagai variabel intervening. Metode penelitian ini adalah penelitian kuantitatif. Pengumpulan data dilakukan melalui kuesioner yang disebarkan kepada pegawai Pengadilan Tata Usaha Negara Gorontalo yang berjumlah 33 responden. Pengambilan sampel dalam penelitian ini menggunakan teknik sampel jenuh. Data yang diperoleh kemudian diolah dengan menggunakan alat bantu SmartPLS. Berdasarkan hasil uji penelitian yang dilakukan menunjukkan bahwa variabel disiplin berpengaruh positif dan signifikan terhadap kinerja pegawai, variabel disiplin berpengaruh positif dan signifikan terhadap motivasi, variabel kompetensi berpengaruh positif dan tidak signifikan terhadap kinerja pegawai, variablel kompetensi berpengaruh positif dan signifikan terhadap motivasi, variabel motivasi berpengaruh positif dan tidak signifikan terhadap kinerja pegawai, variabel motivasi tidak mampu memediasi antara disiplin terhadap kinerja pegawai, variabel motivasi tidak mampu memediasi antara kompetensi terhadap kinerja pegawai.
The Associations Between Functional Mobility, Dynamic Stability and Back Pain in Women After Caesarean Section Surgery
Authors: Žalienė Laura , Arup Irina 
Published: December 2024

Background. Lower back pain is more common in women who have undergone cesarean section surgery than in women whose childbirth was natural. The quality of life is better, and the level of disability is lower in women who have given birth naturally than those who have undergone cesarean section surgery.
The aim. To assess the relationship between women after cesarean section surgery for back pain, functional mobility, and dynamic.
Material and methods. Functional mobility, questionnaire survey, tests of dynamic trunk stability and static endurance, mathematical descriptive statistics.
Results. According to a questionnaire survey, the largest number of women after cesarean section surgery are tormented by lumbar spine pains (58 percent). As many as 6.1 percent of women feel unbearable pain. Half (n=6) of the women in the study had good functional mobility after cesarean section surgery, four were satisfactory and only two were unsatisfactory. Half (n=6) of the women in the study have good dynamic torso stability after cesarean section surgery, five are satisfactory, and only one is unsatisfactory. All women (n=12) in the study complained of pain in the lumbar spine. In half (n=6) women who often felt pain in the lumbar spine, the dynamic stability was unsatisfactory. Meanwhile, for those who sometimes felt pain in the lumbar spine, the dynamic stability was satisfactory. The functional mobility of women who often felt pain in the lumbar spine was satisfactory.
Conclusions. All women who participated in the study of physical and functional condition after cesarean section surgery felt pain in the lower back and all had a discharge of the rectilinear abdominal muscles. Despite the above factors, functional mobility and dynamic and static stability of the torso in most cases were good enough. This may have led to the fact that all the women involved in the study in physical and functional condition were physically active after cesarean section surgery.
Keywords: caesarean section, low back pain, dynamic stability, functional mobility.
Effects of the Getting Ready for School intervention on children's school readiness skills
Authors: Marti-Castaner Maria , Merz Emily C. , Wiltshire Cynthia A. , Melvin Samantha A. , Henry Kimberly , Landers Cassie , Noble Kimberly G. , Duch Helena 
Published: December 2024

IntroductionSkill-based curricula supplementing Head Start programming have shown great promise as early interventions improving school readiness of children from socioeconomically under-resourced families. The Getting Ready for School (GRS) intervention builds on such research by providing a supplemental skill-based curriculum targeting three core school readiness domains—language/literacy, math, and self-regulation—using learning activities aligned across the classroom and home contexts. The goal of this study was to examine the effects of the GRS intervention on school readiness skills in children in Head Start programs.MethodsParticipants were 3- to 4-year-olds (N = 463, 46% male, 81% Hispanic/Latine). Classrooms were non-randomly assigned to the GRS intervention (n = 20) or Head-Start-as-usual comparison group (n = 17). At pretest and posttest, children completed assessments of early language/literacy, math, and self-regulation. Multilevel modeling was used to examine the group-by-time interaction in prediction of children's school readiness skills.ResultsSignificant group-by-time interactions were found for early language/literacy (vocabulary, print knowledge) and math skills. Children in the intervention group demonstrated significantly greater gains over time in these skills compared to children in the comparison group. At posttest, children in the intervention group had significantly higher vocabulary than children in the comparison group (effect size = 0.34). Intervention effects were not found for self-regulation.DiscussionThe GRS intervention may support early language/literacy and math skills in preschool children from socioeconomically under-resourced families. Future studies focused on a modified version of the intervention could demonstrate larger effect sizes and improvements in self-regulation.
Quantitative ultrasound imaging reveals distinct fracture-associated differences in tibial intracortical pore morphology and viscoelastic properties in aged individuals with and without diabetes mellitus – an exploratory study
Authors: Dehnen Carolin , Galindo Angela , Hoff Paula , Palme Oliver , Maurer Lukas , Raum Kay , Wiebe Edgar 
Published: December 2024

IntroductionDiabetes mellitus (DM) is a chronic metabolic disorder that increases fragility fracture risk. Conventional DXA-based areal bone mineral density (aBMD) assessments often underestimate this risk. Cortical Backscatter (CortBS) ultrasound, a radiation-free technique, non-invasively analyzes cortical bone’s viscoelastic and microstructural properties. This study aimed to evaluate CortBS’s discriminative performance in DM patients compared to DXA and characterize changes in cortical bone microstructure in Type 1 and Type 2 DM (T1DM, T2DM) patients.MethodsThis in-vivo study included 89 DM patients (T1DM = 39, T2DM = 48) and 76 age- and sex-matched controls. DXA measured aBMD, while CortBS measurements were taken at the anteromedial tibia using a medical ultrasound scanner with custom software. Multivariate analysis of variance assessed the impact of DM type on CortBS and DXA measurement results. Partial least squares discriminant analyses with cross-validation were used to compare the discrimination performance for vertebral, non-vertebral, and any fragility fractures, adjusting for gender, age, and anthropometric parameters (weight, height, BMI).ResultsFractures occurred in 8/23 T1DM, 17/18 T2DM, and 16/55 controls. DXA parameters were reduced in fracture patients, with significant diabetes impact. T2DM was associated with altered CortBS parameters, reduced scatterer density, and larger pores. CortBS outperformed DXA in discriminating fracture risk (0.61 ≤ AUC(DXA) ≤ 0.63, 0.68 ≤ AUC(CortBS) ≤ 0.69).ConclusionsBoth T1DM and T2DM showed altered bone metabolism, with T2DM linked to impaired tissue formation. CortBS provides insights into pathophysiological changes in diabetic bone and provided superior fracture risk assessment in DM patients compared to DXA.
The introduction of coinage in Europe did not change pre-existing monetary patterns
Authors: Ialongo Nicola 
Published: December 2024

IntroductionThis paper investigates whether the introduction of coinage in Europe fundamentally changed pre-existing monetary circulation patterns. By analysing the statistical properties of bronze money before and after the advent of coinage (c. 1500–27 BCE), it challenges the prevailing assumption that coinage revolutionized the use and exchange of money. The research engages with longstanding academic debates between competing theories, which posit that money is either market-driven or state-imposed.MethodsUsing a combination of archaeological data and quantitative analysis, the study examines large datasets of pre-coinage money and early coinage, focusing on weight-based regulation and the log-normal distribution of mass values as key indicators of monetary behaviour.ResultsThe findings reveal that pre-coinage bronze money, consisting of weighed metal fragments, circulated in a manner similar to early coinage. Both forms of money complied with weight-based systems and exhibited log-normal distribution patterns, reflecting structured economic behaviours. The analysis suggests that the introduction of coinage did not lead to a fundamental transformation in how money circulated but rather continued pre-existing patterns.DiscussionThese results challenge the assumption that state-issued coinage marked a watershed moment in the history of monetary economies. The paper proposes that the beginning of coinage introduced a minor technological improvement rather than a revolutionary change in monetary circulation, offering a new perspective on the continuity between pre-coinage and coinage-based economies in ancient Europe.
Enabling immune checkpoint blockade efficacy in T-lymphopenia by restoring CD8 T cell dynamics with IL-7 cytokine therapy
Authors: Kang Yeon-Woo , Choi Donghoon , Moon Dain , Lee Kun-Joo , Oh Youngsik , Yang Jaehyuk , Jeong Siheon , Park Uni , Im Sun-Kyoung , Yang Se Hwan , Lee Seung-Woo 
Published: December 2024

IntroductionT-lymphopenia (TLP) is a frequently observed condition in cancer patients, often exacerbated by conventional chemo/radiotherapy, which impairs the efficacy of subsequent immune checkpoint blockade (ICB) therapy. This study aimed to understand the impact of TLP on ICB responsiveness and explore potential therapeutic strategies to enhance antitumor immunity.MethodsTo investigate ICB responsiveness depending on the severity of TLP, first, we established TLP mouse models that mimic clinically observed mild and severe TLP through thymectomy and anti-Thy1-induced peripheral T cell depletion. T cell-replete mice and T-lymphopenic mice were inoculated with palpable or advanced tumors to evaluate the antitumor efficacy of anti-PD-1 therapy according to the severity of TLP. Additionally, by utilizing established murine models, we analyzed matched blood, tumor-draining lymph nodes (TDLNs), and tumor samples by flow cytometry to investigate the mechanisms by which ICB responsiveness is impaired under T-lymphopenic conditions. Finally, to evaluate the combination effect of anti-PD-1 and recombinant IL-7 cytokine therapy (rhIL-7-hyFc) in T-lymphopenic conditions, we administered anti-PD-1, rhIL-7-hyFc, or both to advanced tumor-bearing T-lymphopenic mice and subsequently analyzed tumor growth and survival rates.ResultsUsing mouse models mimicking clinical TLP, we observed that the antitumor efficacy of anti-PD-1 therapy was severely impaired in TLP, depending on the degree of TLP and the immunogenicity of the tumors. TLP mice showed a significant reduction in systemic CD8 T cells but stable intratumoral CD8 T cell numbers, suggesting maintained tumor infiltration despite systemic downregulation. Crucially, TLP led to a shift in the composition of tumor-infiltrating lymphocytes, with a decrease in PD-1+ tumor-reactive CD8 T cells and an increase in PD-1− bystander cells. This reduction in PD-1+ cells was linked to impaired clonal expansion in tumor-draining lymph nodes. To counteract these effects, we introduced recombinant IL-7 cytokine therapy (rhIL-7-hyFc), which effectively restored systemic T cell counts, enhanced PD-1+ CD8 T cell proliferation within tumors, and increased the population of stem-like progenitor cells. The combination of rhIL-7-hyFc and anti-PD-1 therapy resulted in significant tumor regression and improved mouse survival.DiscussionOur findings highlight the critical role of IL-7 in reshaping the CD8 T cell landscape to improve ICB efficacy in TLP conditions, proposing a sequential therapeutic approach: conventional therapy to reduce tumor burden and enhance immunogenicity, followed by IL-7 therapy to restore and rejuvenate CD8 T cells, culminating in effective ICB treatment.
Optimizing immunogenicity and product presentation of a SARS-CoV-2 subunit vaccine composition: effects of delivery route, heterologous regimens with self-amplifying RNA vaccines, and lyophilization
Authors: Lykins William R. , Pollet Jeroen , White Jessica A. , Keegan Brian , Versteeg Leroy , Strych Ulrich , Chen Wen-Hsiang , Mohamath Raodoh , Ramer-Denisoff Gabi , Reed Sierra , Renshaw Christina , Beaver Samuel , Gerhardt Alana , Voigt Emily A. , Tomai Mark A. , Sitrin Robert , Choy Robert K. M. , Cassels Frederick J. , Hotez Peter J. , Bottazzi Maria Elena , Fox Christopher B. 
Published: December 2024

IntroductionDozens of vaccines have been approved or authorized internationally in response to the ongoing SARS-CoV-2 pandemic, covering a range of modalities and routes of delivery. For example, mucosal delivery of vaccines via the intranasal (i.n.) route has been shown to improve protective mucosal responses in comparison to intramuscular (i.m.) delivery. As we gain knowledge of the limitations of existing vaccines, it is of interest to understand if changes in product presentation or combinations of multiple vaccine modalities can further improve immunological outcomes.MethodsWe investigated a commercial-stage SARS-CoV-2 receptor binding domain (RBD) antigen adjuvanted with a clinical-stage TLR-7/8 agonist (3M-052) formulated on aluminum oxyhydroxide (Alum). In a murine immunogenicity model, we compared i.n. and i.m. dosing of the RBD-3M-052-Alum vaccine. We measured the magnitude of antibody responses in serum and lungs, the antibody-secreting cell populations in bone marrow, and antigen-specific cytokine-secreting splenocyte populations. Similarly, we compared different heterologous and homologous prime-boost regimens using the RBD-3M-052-Alum vaccine and a clinical-stage self-amplifying RNA (saRNA) vaccine formulated on a nanostructured lipid carrier (NLC) using the i.m. route alone. Finally, we developed a lyophilized presentation of the RBD-3M-052-Alum vaccine and compared it to the liquid presentation and a heterologous regimen including a previously characterized lyophilized form of the saRNA-NLC vaccine.Results and discussionWe demonstrate that i.n. dosing of the RBD-3M-052-Alum vaccine increased IgA titers in the lung by more than 1.5 logs, but induced serum IgG titers 0.8 logs lower, in comparison to i.m. dosing of the same vaccine. We also show that the homologous prime-boost RBD-3M-052-Alum regimen led to the highest serum IgG and bronchial IgA titers, whereas the homologous saRNA-NLC regimen led to the highest splenocyte interferon-γ response. We found that priming with the saRNA-NLC vaccine and boosting with the RBD-3M-052-Alum vaccine led to the most desirable immune outcome of all regimens tested. Finally, we show that the lyophilized RBD-3M-052-Alum vaccine retained its immunological characteristics. Our results demonstrate that the route of delivery and the use of heterologous regimens each separately impacts the resulting immune profile, and confirm that multi-product vaccine regimens can be developed with stabilized presentations in mind.
Impact of steroid-sparing immunosuppressive agents on tumor outcome in the context of cancer immunotherapy with highlight on melanoma: a systematic literature review and meta-analysis
Authors: Strouse Jennifer , Chan Karmela Kimi , Baccile Rachel , He Gong , Louden Diana K. N. , Giurcanu Mihai , Singh Arohi , Rieth John , Abdel-Wahab Noha , Katsumoto Tamiko R. , Singh Namrata , Rouhani Sherin , Reid Pankti 
Published: December 2024

BackgroundThe impact of steroid-sparing immunosuppressive agents (SSIAs) for immune-related adverse events (irAEs) on tumor outcome is not well-known. This systematic review evaluates tumor outcomes for corticosteroid (CS) monotherapy versus CS with SSIA (CS-SSIA) for irAE treatment with a focus on melanoma.MethodsSearch was conducted through 1/5/23 using PubMed, Embase, Cochrane CENTRAL, and Web of Science. We included case series, retrospective/prospective observational studies and interventional clinical trials. Individual-level data was analyzed using KM curves and Cox regression for overall survival (OS) and progression free survival (PFS). Time to SSIA was treated as a time-varying exposure using landmark analysis (landmark timepoint=3 months after irAE) to account for immortal time bias. For group-level data, meta-analysis compared the use of SSIA to No SSIA for irAEs.ResultsOf twenty-two publications with individual-level data, 147 patients with any cancer (57 CS, 90 CS-SSIA) and 65 with melanoma (18 CS, 47 CS-SSIA) underwent landmark analysis. Twenty-two publications underwent group-level evaluation and four were included in the meta-analysis. CS-SSIA versus CS showed higher risk of all-cause mortality and progression (HR 2.75, 95%CI: 1.44-5.27, p&lt;0.01 and HR 1.75, 95%CI: 1.07-2.85, p=0.03, respectively). Melanoma showed worse OS and PFS for CS-SSIA versus CS (HR 5.68, 95%CI: 1.31-24.67, p=0.02 and HR 2.68, 95%CI: 1.12-6.40, p=0.03, respectively). In the meta-analysis of group-level data (n=2558), we found worse OS and PFS for CS-SSIA versus No SSIA (HR 1.58, 95%CI: 1.25; 2.01, p&lt;0.01 and 1.70, 95%CI: 1.25-2.33, p&lt;0.01). Tumor necrosis factor-alpha inhibitors (TNFi) were the most common SSIA. In the melanoma cohort, TNFi had worse OS and PFS versus CS (HR 6.46, 95%CI: 1.43-29.19, p = 0.02 and HR 7.49, 95%CI: 2.29-24.48, p&lt;0.01, respectively). TNFi versus Other SSIAs showed a trend toward worse OS and worse PFS (HR 6.96, 95%CI: 0.90-53.65, p=0.06 and HR 21.5, 95%CI: 2.63-175.8, p&lt;0.01, respectively). Meta-analysis showed a concern for TNFi compared to Other SSIA (HR 1.56, 95%CI: 1.17-2.09, p&lt;0.01 respectively).ConclusionsWhile our results raise concern about the effects of CS-SSIA and TNFi for irAE therapy on tumor outcomes, prospective randomized controlled trials are needed to definitively assess the effect of SSIAs on tumor outcomes.
Molecular cloning, expression and functional analysis of foxl2 from Chinese sturgeon (Acipenser sinensis) in relation to sex differentiation
Authors: Hu Yacheng , Tan Ruihua , Li Yang , Shu Tingting , Yang Gang , Chu Zhong , Wang Haoran , Liu Xueqing , Zhu Xin , Wang Binzhong , Guo Baifu , Wang Runqiu , Qu Huantao , Song Haoyong , Zhang Dezhi , Du Hejun , Li Zhiyuan , Chang Jianbo , Wang Dianchang , Xu Dan , Jiang Wei , Li Qingfei , Yang Yuanjin 
Published: December 2024

IntroductionOur understanding of the regulatory mechanisms that govern the development of sexual characteristics in sturgeon, particularly the Chinese sturgeon (Acipenser sinensis), is limited. Foxl2, a member of the forkhead/HNF-3-related transcription factor family, is known for its role in precise gene regulation within specific tissues and its control over ovarian aromatase, a key enzyme in ovarian development and maturation. This study aimed to investigate the sexually dimorphic expression of foxl2 during the molecular and morphological sex differentiation stages in Chinese sturgeon.MethodsWe successfully isolated the full-length cDNAs of foxl2 in Chinese sturgeon. We then examined the expression profiles of this gene across various somatic tissues in both female and male specimens.ResultsFoxl2 was predominantly expressed in the ovulatory organs of two-year-old Chinese sturgeon, with significantly lower expression in other somatic tissues. We observed sexual dimorphism in foxl2 expression within gonads that had achieved morphological differentiation.DiscussionThe results suggest that foxl2 expression is intricately linked to the process of ovarian differentiation in Chinese sturgeon. Furthermore, we propose that the mRNA quantities of foxl2 could serve as an accurate biomarker for sex determination in sturgeon during their early growth stages.
Understanding the influence of plant genetic factors on rhizosphere microbiome assembly in Panax notoginseng
Authors: Shi Liping , Yang Mingming , Wei Guangfei , Wei Xiuye , Hong Fei , Ma Jiaxiang , Wu Zhe , Zheng Yuqing , Yang Miyi , Chen Shilin , Zhang Guozhuang , Dong Linlin 
Published: December 2024

IntroductionFunctional rhizosphere microbiomes (FRM) are critical for plant health and yield. However, the ecological succession of FRM and their links to plant genetic factors across the life cycle of perennial plants remain poorly understood.MethodsThis study profiled FRM, including plant-beneficial bacteria (PBB) and fungal plant pathogens (FPP), across different developmental stages of Panax notoginseng.ResultsThe biodiversity of both PBB and FPP were significantly higher in rhizosphere compared with farmland soil, and exhibited different succession patterns with plant growth. The relative abundance of PBB, but not FPP, decreased after plant cultivation. There were significantly negative correlations between FPP and PBB, particularly the biocontrol subgroup (ρ = −0.56, p &lt; 0.001). The antagonistic effects of biocontrol bacteria against fungal pathogens were further validated by in vitro assays. The fitting of neutral community model indicated that the deterministic assembly of PBB, especially the biocontrol subgroup, was the strongest at the 3rd-year root growth stage of P. notoginseng. Plant genes involved in protein export, biosynthesis of alkaloids and amino acids were identified as drivers of the deterministic assembly of biocontrol subcommunity by RNA-Seq analysis. Additionally, a total of 13 transcription factors potentially regulating the expression of these biosynthesis genes were identified through co-expression network. In summary, this study unveils the succession patterns of FRM throughout the life cycle of P. notoginseng and the underlying plant genetic mechanisms, providing valuable insights for developing new plant disease management strategies by manipulating microbes.