bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Oral Contraceptives and Metformin on The Concentrations of Anti-Müllerian Hormone in Women with Polycystic Ovary Syndrome
Authors: Wang Liping , Hua Ke , Cai Wenwei , Fu Weiping , Zhang Hongxia , Fang Chunxia 
Published: July 2020

Abstract
Background: Whether treatment with oral contraceptives (OC) and metformin can reduce anti-Müllerian hormone (AMH) levels in PCOS remains controversial. This study aims to investigate the effects of OC and metformin on serum AMH concentrations in women with polycystic ovary syndrome (PCOS). Methods: This prospective study included 120 women with PCOS. Patients were treated with OC (35 μg of ethinyl estradiol plus 2 mg of cyproterone acetate), metformin, or OC plus metformin for 3 months according to their different endocrine/metabolic disturbances. Forty-eight patients with hyperandrogenism (HA) were treated with OC, 32 patients with insulin resistance (IR) were treated with metformin, and 40 patients with HA and IR were treated with a combination of OC and metformin. Serum AMH levels were compared before and after treatment within each group.Results: AMH levels decreased significantly in both OC groups (from 12.54 ± 5.59 ng/mL before treatment to 9.03 ± 4.49 ng/mL after treatment, P < 0.01) as well as in the OC + metformin group (from 10.62 ± 4.57 ng/mL to 7.74 ± 3.19 ng/mL, P < 0.01). However, AMH concentrations remained unchanged in the metformin group, although insulin sensitivity was improved. Conclusion: Treatment with OC alone or OC plus metformin led to a significant reduction of serum AMH in PCOS patients with HA, while metformin treatment alone did not affect AMH levels in patients with IR.
Designing and Evaluation of E-Health Educational Intervention on Students' Physical Activity: An Application of Pender's Health Promotion Model
Authors: Sabooteh Sahar , Feizi Awat , Shekarchizadeh Parivash , Shahnazi Hossein , Mostafavi Firoozeh 
Published: July 2020

Abstract
Background: The purpose of this study was to design and evaluate the software and web-based curriculum based on Pender Model to promote students' physical activity.Methods: This is a quasi-experimental study that was conducted on 225 eligible students who were randomly divided into 2 groups of Web and software-based intervention and control. The sample size of the study was selected from the students using stratified sampling method. Evaluation was done by pre-test and post-test and follow-up was performed immediately, 2 and 6 months after the intervention. The data were analyzed by statistical software SPSS using descriptive statistics, chi-square, one way ANOVA and repeated measures ANOVA.Results: The study results showed that the level of physical activity after the intervention in the web and software groups was significantly increased compared to the control group (p <0.001). Also, the mean score of Pender model constructs, immediately, 2 and 6 months after the intervention was significantly different in the web and software groups (p <0.001). Conclusion: It seems that designing and implementing educational program based on Pender model and its presentation in the form of educational software and web has a positive effect on promoting physical activity of students.
CogTale: An Online Platform for the Evaluation, Synthesis and Dissemination of Evidence From Cognitive Interventions Studies
Authors: Sabates Julieta , Belleville Sylvie , Castellani Mary , Dwolatsky Tzvi , Hampstead Benjamin M. , Lampit Amit , Simon Sharon , Anstey Kaarin J. , Goodenough Belinda , Mancuso Serafino , Marques Davis , Sinnott Richard , Bahar-Fuchs Alex 
Published: July 2020

Abstract
Systematic reviews and meta-analyses are critical in health-related decision making, and are considered the gold standard in research synthesis methods. However, with new trials being regularly published and with the development of increasingly rigorous standards of data synthesis, systematic reviews often require much expertise and long periods of time to be completed. Automation of some of the steps of evidence synthesis productions is a promising improvement in the field, capable of reducing the time and costs associated with the process.This article describes the development and main characteristics of a novel online repository of cognitive intervention studies entitled Cognitive Treatments Article Library and Evaluation (CogTale). The platform is currently in a Beta Release phase, as it is still under development. However, it already contains over 70 studies, and the CogTale team is continuously coding and uploading new studies into the repository. Key features include several automatically-calculated methodological quality indices and effect sizes, carrying out meta-analyses, and the generation of evidence reports including certainty ratings.
Intra-Articular Pressure in Osteoarthritis of the Knee
Authors: niu kai , Pan le hai 
Published: July 2020

Abstract
Background: IAP （intra-articular pressure）of the knee has been extensively studied in the knee of rheumatoid arthritis1.3 . the relationship between IAP and osteoarthrosis of knee rarely mentioned in the literature. The purpose of the study was to discover the pressure profiles observed in OA(Osteoarthritis ）. The characteristics of osteoarthritis are multiple osteophytes, unstable chondral flaps ,joint-space narrowing，sclerosis. Whether these factors effect of osteoarthritis intra-articular pressure.Methods: Fifty three research subjects were studied. They were divided into two subgroups, group 1: Forty osteoarthritis (OA). group 2: Thirteen control knee of healthy volunteer. IAP was measured using the hand held portable water manometer. before operation of arthroscopic procedures in OAgroup . Research data were analyzed to identify IAP between the two groups. Results: The main findingwasthat Resting IAP was positive pressure in all Osteoarthritis joints, otherwise subatmospheric or weakly atmospheric in normal subjects. Conclusions: The IAP rising is a feature of all patients with OAgroup. Therefore, These observations we recognize that significantly increased resting IAP is major influences by multiple osteophytes, joint-space narrowing，sclerosis , loose bodies and definite deformity of bony ends.
Improving Structure Based Models for Predicting Chemical Functions and Weight Fractions in Cosmetic Products using Ensemble Support Vector Machine
Authors: Vojinovic Tanja B , Kascelan Ljiljana , Potpara Zorica , Radonjic Natasa , Kascelan Zorka 
Published: July 2020

Abstract
Through usage of a large number of cosmetic products, consumers are very often exposed to toxic chemicals. This paper is aimed at proposing a model for the prediction of chemical functions and weight fractions in these products based on the structural and physical-chemical properties of the chemicals. Due to the imbalance of classes we used Support Vector Machine (SVM) method, which can complement a smaller class with the examples that are most similar to it and identify the examples that are most different. The generality of the SVM method was additionally enhanced by combining it with ensemble Bootstrap Aggregation (Bagging). The research results show that the proposed bagging SVM method can overcome the disadvantages of previously applied methods. Further, it can help address the lack of information needed to assess exposure to risk from the use of cosmetic products containing toxic chemicals in their composition. The proposed models can be applied to predict whether a certain chemical may be a substitute for a function performed by another possibly toxic chemical in a cosmetic product, as well as well as to determine the quantity proportion of a certain dangerous chemical on the basis of its chemical structure and physical-chemical properties.
Interobserver Variability in Organ at Risk Delineation in Head and Neck Cancer.
Authors: Veen Julie van der , Gulyban Akos , Willems Siri , Maes Frederik , Nuyts Sandra 
Published: July 2020

Abstract
Background: In radiotherapy inaccuracy in organ at risk (OAR) delineation can impact treatment plan optimisation and treatment plan evaluation. Brouwer et al. showed significant interobserver variability (IOV) in OAR delineation in head and neck cancer (HNC) and published international consensus guidelines (ICG) for OAR delineation in 2015. The aim of our study was to evaluate IOV in the presence of these guidelines. Methods: HNC radiation oncologists (RO) from each Belgian radiotherapy centre were invited to complete a survey and submit contours for 5 HNC cases. Reference contours (OARref) were obtained by a clinically validated artificial intelligence-tool trained using ICG. Dice similarity coefficients (DSC), mean surface distance (MSD) and 95% Hausdorff distances (HD95) were used for comparison.Results: Fourteen of twenty-two RO (64%) completed the survey and submitted delineations. Thirteen (93%) confirmed the use of delineation guidelines, of which six (43%) used the ICG. The OARs whose delineations agreed best with the OARref were mandible (median DSC 0.9, range [0.8-0.9]; median MSD 1.1mm, range [0.8-8.3], median HD95 3.4mm, range [1.5-38.7]), brainstem (median DSC 0.9 [0.6-0.9]; median MSD 1.5mm [1.1-4.0], median HD95 4.0mm [2.3-15.0]), submandibular glands (median DSC 0.8 [0.5-0.9]; median MSD 1.2mm [0.9-2.5], median HD95 3.1mm [1.8-12.2]) and parotids (median DSC 0.9 [0.6-0.9]; median MSD 1.9mm [1.2-4.2], median HD95 5.1mm [3.1-19.2]). Oral cavity, cochleas, PCMs, supraglottic larynx and glottic area showed more variation. RO who used the consensus guidelines showed significantly less IOV (p=0.008).Conclusion: Although ICG for delineation of OARs in HNC exist, they are only implemented by about half of RO participating in this study, which partly explains the delineation variability. However, this study highlights that guidelines alone do not suffice to eliminate IOV and that more effort needs to be done to accomplish further treatment standardisation, for example with artificial intelligence.
Characterization of the Metrnl Serum Levels in Patients with Inflammatory Bowel Disease and its Association with Inflammatory Cytokines
Authors: Gholamrezayi Afsane , Mohamadinarab Maryam , Rahbarinejad Pegah , Fallah Soudabeh , Barez Shekufe Rezghi , Setayesh Leila , Moradi Nariman , Fadaei Reza , Chamani Elham , Tavakoli Tahmine 
Published: July 2020

Abstract
Background
Meteorin-like (Metrnl) is a newly discovered adipokine with the anti-inflammatory and insulin sensitizing properties. Accordingly, Metrnl regulates glucose tolerance, enhances metabolism in body tissues, and induces thermogenesis in white adipose tissue. However, the correlation among Metrnl, IBD, and obesity still remains unexplored.
Methods
The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn's disease (CD) patients who were diagnosed by pathological examination. In these patients, serum levels of adiponectin, Metrnl, IL-6, and TNF-α were measured using ELISA kits.
Results
Metrnl concentration significantly decreased in both of the UC (85.25 ± 36.55 pg/mL) and CD (76.93 ± 27.92 pg/mL) patients compared to control group (107.52 ± 35.33 pg/mL). Similarly, adiponectin has also decreased in these two patient groups compared to the controls. However, IL-6 and TNF-α significantly increased in both of the patient groups. Moreover, Metrnl indicated an inverse relationship with BMI in the controls and both of the patient groups. In addition, there was an inverse correlation among Metrnl, IL-6, and TNF-α in both of the patient groups.
Conclusions
The current study is the first one reporting the decreased Metrnl serum level in the patients with IBD, which is inversely related to BMI, TNF-α, and IL-6. These results suggested a possible role for Metrnl in the pathogenesis of IBD, particularly through inflammation modulating.
The Impact of Propofol- and Inhalant-Based Anesthesia on Acute Kidney Injury After Major Abdominal Surgery: A Retrospective Observational Study
Authors: Kim Bo Rim , Yoon Susie , Song Gyu Young , Lee Seohee , Bahk Jae-Hyon , Nam Karam 
Published: July 2020

Abstract
Background: The optimal anesthetic for preventing postoperative acute kidney injury (AKI) remains unclear, and few studies on this topic have been conducted in the context of non-cardiac surgery. The purpose of this retrospective study was to compare propofol- and inhalant-based anesthesia in terms of the risk of AKI after open major abdominal surgery (MAS).Methods: Adult patients who underwent open MAS (gastrectomy, hepatectomy, colectomy, or pancreatectomy) at our institute from January 2016 to December 2018 were included. Using multivariable logistic regression, the risk of postoperative AKI was compared between patients who underwent propofol-based anesthesia (propofol group) and those who received inhalant-based anesthesia (inhalant group). Additional logistic regression analyses were performed after propensity score matching and inverse probability of treatment weighting (IPTW).Results: In total, 3,616 patients were analyzed. The incidence of postoperative AKI was 5.0% (77/1546) and 7.8% (161/2070) in the propofol and inhalant groups, respectively. The risk of AKI was significantly higher in the inhalant group (adjusted odds ratio [aOR], 1.69; 95% confidence interval [CI], 1.23–2.30; P= 0.001) than the propofol group. In the propensity score-matched cohort, the inhalant group had a higher risk of AKI than the propofol group (aOR, 1.68; 95% CI, 1.21–2.34; P= 0.002), and the logistic regression with IPTW showed similar results (OR, 1.74; 95% CI 1.14–1.66; P< 0.001).Conclusion: The risk of AKI after open MAS may differ significantly according to the anesthetic used. Patients receiving inhalant-based anesthesia may have a greater risk of postoperative AKI than those anaesthetized with propofol.
Arm and finger measurements in pregnant Asian parturients and their implications on blood pressure measurement: a prospective cohort study
Authors: Lim Ming Jian , Tan Chin Wen , Tan Hon Sen , Sultana Rehena , Eley Victoria , SNG Ban Leong 
Published: July 2020

Abstract
Background
Accurate blood pressure (BP) measurement depends on appropriate cuff size and shape in relation to the arm. Arm dimensions outside the recommended range of cuff sizes or trunco-conical arms may result in inaccurate BP measurements. Measuring BP using finger cuffs is a potential solution. Arm cuff size is based on mid-arm circumference (MAC), and trunco-conicity is quantified by conicity index. We aimed to determine the correlation of MAC, body mass index (BMI), and weight with conicity index.
Methods
A prospective cohort study was conducted in the KK Women’s and Children’s hospital where third trimester parturients scheduled for cesarean delivery were recruited after obtaining informed consent. Parturients were asked to rate their experience with time taken to obtain BP readings, cuff popping off during measurement, need to move the cuff from the upper arm to lower arm or leg, and need to change to a different cuff. Our primary outcome was the correlation between MAC and conicity index, calculated using Pearson’s correlation. The correlation between BMI and weight with conicity index was also determined.
Results
We enrolled 300 parturients. Moderate correlation was found between left MAC and left conicity index (r = 0.41, 95% CI 0.32 to 0.51), and right MAC and right conicity index (r = 0.39, 95% CI 0.29 to 0.48). Weight (r = 0.35 to 0.39) and BMI (r = 0.41 to 0.43) correlated with conicity index in this study. MAC of 1 parturient fell outside the recommended range for arm cuffs, but all parturients fit into available finger cuffs. Obese parturients had increased problems with arm cuffs popping off and needing a change of cuff.
Conclusions
BMI better correlated with conicity index compared to MAC or weight. Standard finger cuffs were suitable for all parturients studied and may be a suitable alternative.
Trial registration:
Clinicaltrials.gov NCT04012151. Registered 9 Jul 2019 https://clinicaltrials.gov/ct2/show/NCT04012151
Developing EU environmental standards for the food, drink and milk industries: key environmental issues and data collection
Authors: Santonja German Giner , Karlis Panagiotis 
Published: July 2020

Abstract
Background
The European Commission organised the review of the best available techniques reference document for the food, drink and milk industries according to the provisions of the Industrial Emissions Directive (Directive 2010/75/EU). Under this policy, an exchange of information between Member States, industrial organisations, non-governmental organisations promoting the protection of the environment and the European Commission took place.
Results
A crucial part for developing these EU environmental standards was the determination of the key environmental issues of the food, drink and milk sector. Key environmental issues were defined for emissions to air and water, and for energy and water consumption. The key environmental issues were determined by using four criteria proposed by the European Commission. Moreover, a data collection procedure was designed and real-plant emissions and consumption data were obtained from a variety of food, drink and milk installations across the European Union.
Conclusions
The development of the EU environmental standards for the food, drink and milk sector will be the reference for the operation of around 2 800 installations in Europe until these standards are reviewed again.
Repair of an Isolated Right Partial Anomalous Pulmonary Venous Connection by Rerouting Blood Flow Through an Interatrial Septum Flap in a 68-Year-Old-Woman: A Case Report
Authors: Morishtia Atsushi , Hagino Ikuo , Tomioka Hideyuki , Katahira Seiichiro , Hoshino Takeshi , Hanzawa Kazuhiko 
Published: July 2020

Abstract
Background: Partial anomalous pulmonary venous connection draining into the right atrium with an intact atrial septum is a very rare clinical entity in the adult population. Partial anomalous pulmonary venous connection must be suspected as a differential diagnosis when the cause of right heart enlargement and pulmonary artery hypertension is unknown.Case presentation: This study describes the surgical case of an isolated right partial anomalous pulmonary venous connection to the right atrium in a 68-year-old woman, who underwent tricuspid ring annuloplasty and right-sided maze procedure simultaneously. She had complaints of gradually progressing dyspnea on exertion. However, a diagnosis could not be established despite consultations at multiple hospitals for over a year. Right heart catheterization revealed severe pulmonary artery hypertension with a mean pulmonary artery pressure of 46 mmHg, step-up phenomenon of oxygen saturation at the mid-level of the right atrium with a pulmonary-to-systemic blood flow ratio of 2.4, and a pulmonary vascular resistance of 3.1 Wood Units. In addition, it was mandatory to comprehensively utilize valuable imaging modalities, such as transthoracic echocardiography, transesophageal echocardiography, and multidetector computed tomography angiography for the accurate diagnosis and efficient surgical planning of this partial anomalous pulmonary venous connection. As medical treatment with pulmonary artery vasodilator therapy did not improve her symptoms, she underwent surgical repair. An atrial septal defect was created surgically with a curvilinear tongue-shaped cut. The right anomalous pulmonary veins were rerouted through the surgically created atrial septal defect into the left atrium with a baffle comprised of the interatrial septum flap, kept in continuity with the anterior margin and sutured while mobilizing the enlarged right atrium. The patient had an uneventful postoperative course and remains asymptomatic. Conclusions: The described surgical technique could be considered an effective alternative for patients undergoing surgical repair for a partial anomalous pulmonary venous connection isolated to the right atrium. The indication for surgery must be judged on a case-by-case basis in these patients with prevalent systemic-to-pulmonary shunting.
The Impact of Diabetes Mellitus on Acute Kidney Injury after Coronary Artery Bypass Grafting
Authors: Wang Rui , Zhang Hang , Zhu Yifan , Chen Wen , Chen Xin 
Published: July 2020

Abstract
Background: Diabetes mellitus(DM) is an indicator affects postoperative mortality and morbidity after coronary artery bypass grafting (CABG). Acute kidney injury (AKI) is one of the frequent postoperative complications after CABG. This multi-centre register study designed to investigate the impact of DM on postoperative AKI in primary isolated CABG patients. Methods: We included all patients (n =4325) from Jiangsu Province CABG register who underwent primary isolated CABG from September 2017 to August 2019. The patients were divided into 3 groups: A group(non-DM, n=3067), B group(DM with oral hypoglycemic agents, n=706) and C group(DM with insulin treatment, n=552). The development and severity of AKI were based on Acute Kidney Injury Network (AKIN) criteria. Results: There were totally 338, 108 and 145 patients developed AKI in A,B and C group respectively. Comparing with A group , B group had a higher rate of AKI(c2=10.071, p=0.002), C group had a higher rate(c2=94.042, p＜0.001) and severity of AKI(c2=10.649, p=0.005). The adjusted odds ratio for AKI was 1.26 (95% CI 1.03-1.57) in B group and 3.92 (95% CI 3.27-5.16) in C group, in comparison with A group. Conclusions: Independent of baseline renal function or cardiac function, DM was associated with an increased risk of AKI after CABG, especially in patients with insulin treatment, who also had a higher severity of AKI.
FABP5 enhances malignancies of lower-grade gliomas via canonical activation of NF-κB signaling
Authors: Wang Jia , Alafate Wahafu , Wang Yichang , Wu Wei , Xiang Jianyang , Ma Xudong , Wang Ning , Liu Hao , Bai Xiaobin , Huo Longwei , Xu Dongze , Wang Maode , Xie Wanfu 
Published: July 2020

Abstract
Background
Lower-grade gliomas (LGGs) are grade II/III gliomas based on the WHO classification with significant genetic heterogeneity and clinical properties. Traditional histological classification of gliomas has been challenged by the improvement of molecular stratification, however, the reproducibility and diagnostic accuracy of LGGs classification remain poor.
Methods
In this study, we derived all relevant data of LGGs including TCGA and CGGA databases from official websites. Bioinformatic analyses unveiled the clinical significance of FABP5 and its potential downstream targets. IHC, qRT-PCR and western blot assays were further conducted to validate those bioinformatic findings. Moreover, lentiviral transduction assays were performed to evaluate the function of FABP5 in patient-derived cell lines.
Results
We identified fatty acid binding protein 5 (FABP5) as one of the most enriched genes in malignant LGGs and elevated FABP5 revealed severe outcomes in LGGs. Functionally, lentiviral suppression of FABP5 reduced malignant characters including proliferation, cloning formation, migration, invasion and TMZ resistance, contrarily, the malignancies of LGGs were enhanced by exogenous overexpression of FABP5. Mechanistically, epithelial-mesenchymal transition (EMT) was correlated to FABP5 expression in LGGs and tumor necrosis factor α (TNFα)-dependent NF-κB signaling was involved in this process. Furthermore, FABP5 induced phosphorylation of inhibitor of nuclear factor kappa-B kinase α (IKKα) thus activated nuclear factor kappa-B (NF-κB) signaling.
Conclusion
Taken together, our study indicated that FABP5 enhances malignancies of LGGs through canonical activation of NF-κB signaling, which could be used as individualized prognostic biomarker and potential therapeutic target of LGGs.