bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bloodstream Infections With a Novel Nontuberculous Mycobacterium Involving 52 Outpatient Oncology Clinic Patients―Arkansas, 2018
Authors: Labuda Sarah M , Garner Kelley , Cima Michael , Moulton-Meissner Heather , Laufer Halpin Alison , Charles-Toney Nadege , Yu Peter , Bolton Erin , Pierce Reid , Crist Matthew B , Gomes Danica , Gable Paige , McAllister Gillian , Lawsin Adrian , Houston Hollis , Patil Naveen , Wheeler J Gary , Bradsher Robert , Vyas Keyur , Haselow Dirk 
Published: November 2019

Abstract

Background
In July 2018, the Arkansas Department of Health (ADH) was notified by hospital A of 3 patients with bloodstream infections (BSIs) with a rapidly growing nontuberculous Mycobacterium (NTM) species; on 5 September 2018, 6 additional BSIs were reported. All were among oncology patients at clinic A. We investigated to identify sources and to prevent further infections.

Methods
ADH performed an onsite investigation at clinic A on 7 September 2018 and reviewed patient charts, obtained environmental samples, and cultured isolates. The isolates were sequenced (whole genome, 16S, rpoB) by the Centers for Disease Control and Prevention to determine species identity and relatedness.

Results
By 31 December 2018, 52 of 151 (34%) oncology patients with chemotherapy ports accessed at clinic A during 22 March–12 September 2018 had NTM BSIs. Infected patients received significantly more saline flushes than uninfected patients (P &lt; .001) during the risk period. NTM grew from 6 unused saline flushes compounded by clinic A. The identified species was novel and designated Mycobacterium FVL 201832. Isolates from patients and saline flushes were highly related by whole-genome sequencing, indicating a common source. Clinic A changed to prefilled saline flushes on 12 September as recommended.

Conclusions
Mycobacterium FVL 201832 caused BSIs in oncology clinic patients. Laboratory data allowed investigators to rapidly link infections to contaminated saline flushes; cooperation between multiple institutions resulted in timely outbreak resolution. New state policies being considered because of this outbreak include adding extrapulmonary NTM to ADH’s reportable disease list and providing more oversight to outpatient oncology clinics.
Burn Nurse Competency Utilization: Report From the 2019 Annual American Burn Association Meeting
Authors: Carrougher Gretchen J , Burton-Williams Kristen , Gauthier Kristy , Gloger Amy , Remington Lois , Yukon Kelli 
Published: November 2019

Abstract
Competence in healthcare is a recognized expectation by consumers. In 2018 following an extensive review and consensus-building process, burn nursing practice competencies were published. Clinical nurse leaders were called upon to use these published competencies in practice as a basis for the requisite knowledge and skills needed in the care of the burn-injured individual. In 2019 at the 51st Annual Meeting of the American Burn Association, nurses from four U.S. burn centers reported on their center’s incorporation of the competencies within their educational nursing curriculums. This paper provides a forum for each of the lead authors from Rhode Island Hospital Burn Center, the University of Utah Health Burn Trauma Intensive Care Unit, Parkland Regional Burn Center, and the University of Chicago Medicine Burn Center to outline their current utilization of the new burn nurse competencies and plans for future use.
Competence in nursing practice is a recognized expectation by the U.S. healthcare consumer. The ability to demonstrate competence is also important to authoritative entities such as The Joint Commission (TJC) and other verifying agencies or societies (e.g., the American Burn Association for burn center verification). Without established and recognized standards of nursing care and documented educational preparation for staff, burn centers cannot ensure consistent and competent care.
Changes of Extravascular Lung Water as an Independent Prognostic Factor for Early Developed ARDS in Severely Burned Patients
Authors: Wang Weiyi , Xu Ning , Yu Xiaofeng , Zuo Fengli , Liu Jie , Wang Yuan , Zhu Guoqin , Jia Naixin , Ren Hui , Zhang Jiaping 
Published: November 2019

Abstract
An important feature of acute respiratory distress syndrome (ARDS) is fluid lost into the interstitium of lung combined with its compromised reabsorption, resulting in the elevation of extravascular lung water (EVLW). Although ARDS is known as an early, common, and life-threatening complication in major burns, the issue of whether or how the EVLW index (EVLWI) correlates with its prognosis has not been identified yet. In this retrospectively study, 121 severely burned adults with ARDS occurred in 2 weeks postburn were analyzed and divided into two groups: survivors (73 patients) and nonsurvivors (48 patients) according to the 28-day outcome after injury. Compared with nonsurvivors, survivors exhibited bigger EVLWI reduction in day 2 after ARDS onset (ΔEVLWI2), with no differences in ARDS timing and other EVLWI variables. ΔEVLWI2, rather than EVLWI on 2 days after ARDS onset, was identified as an independent prognostic factor even after adjusting other significant factors by Cox proportional hazard analysis. ROC curve analysis showed that ΔEVLWI2 [AUC = 0.723, 95% CI = (0.631–0.816), P &lt; .001] was a relative predictor for survival on 28-day postburn, with a threshold of 1.9 ml/kg (63.0% sensitivity, 77.1% specificity). Kaplan–Meier survival curve analysis confirmed a significantly higher survival rate on 28-day postburn in patients with ΔEVLWI2 &gt; 1.9 ml/kg (log-rank test: χ 2 =14.780, P &lt; .001). Taken together, our study demonstrated that ΔEVLWI2 is an independent prognostic factor for early ARDS in severe burns. ΔEVLWI2 higher than 1.9 ml/kg might predict a higher survival rate in those patients.
Inpatient Data of Occupational Burn Injuries Treated at a Tertiary Burn Center
Authors: Basaran Abdulkadir , Ozlu Ozer 
Published: November 2019

Abstract
Occupational burns are among the important causes of work-related injuries. We aimed to investigate the epidemiology and reasons of occupational burns and thereby to emphasize preventive measures. Between January 2017 and December 2018, the data of major occupational burn injury patients admitted to our burn center were evaluated in this cross-sectional retrospective study. During the study period 342 patients older than 16 years were admitted to the burn center. Among them 80 patients with occupational burns (23.4%) were identified. The mean age of the patients was 34.73 ± 12.3 years. Seventy-eight patients (97.5%) were male. Electrical burns and flame burns were the two leading type of occupational burns. The most common occupation of our patients was construction work. Dangerous behavior, carelessness, lack of protective equipment, and failure to follow instructions were causes of injury. Only 14 patients (17.5%) experienced unavoidable accident. Thirty-seven patients (46.3%) worked on temporary basis. Occupational experience was under 5 years in majority of the cases (62.5%). For the occupational burns the percentage of burned TBSA was 17.08 ± 14.5 (1–60) and the length of hospital stay was 23.94 ± 21.9 days (2–106). There were no significant differences between occupational and nonoccupational burn injuries considering TBSA, total length of hospital stay, and complications (P &gt; .05). Occupational burn injuries are common in less experienced and younger workers. Therefore, recognition of the problem and maintaining awareness is important. In order to prevent occupational accidents and burns, occupational health and safety rules must be obeyed.
Woman’s entrepreneurship as a gendered niche: the implications for regional development policy
Authors: Harrison Richard T , Leitch Claire M , McAdam Maura 
Published: November 2019

AbstractIn this article, we argue that entrepreneurship is a socio-spatial embedded activity and that the social construction of gender, time, space, economy and culture is manifest in the masculinities that are ascribed a normative role in entrepreneurship development policies. Drawing on feminist approaches to articulate and perform resistance to the hegemonic ‘masculinist’ discourses on entrepreneurship, we argue that women’s entrepreneurship is contextually embedded in institutional and social structures that both limit and provide opportunities for its enactment. Regional economic development policy has focused, inter alia, on stimulating and supporting women’s entrepreneurship through the establishment of women-only entrepreneurial networks to provide support, role models and access to resources. Grounded in feminist geography and based on a detailed qualitative study of network managers and members of formally established women-only networks, we provide evidence of the disconnect between the emancipatory intent and the actual impact of these initiatives. While these networks aim to empower and encourage women into entrepreneurship, in practice, they perpetuate women’s marginalisation and ghettoisation in gendered niches.
Failure behaviour and acoustic emission characteristics of different rocks under uniaxial compression
Authors: Wang Zhaohui , Wang Jiachen , Yang Shengli , Li Lianghui , Li Meng 
Published: November 2019

Abstract
In the present study, mechanical behaviour of three types of rocks has been investigated under uniaxial compression. The stress–strain responses of the tested rocks are composed of four regions: the compaction stage; elastic stage; strain hardening stage and strain softening stage. The elastic modulus and uniaxial compressive strength increase in order from the result of the coal to the mudstone and then to the sandstone, while the Poisson ratio shows a reverse order. In coal and mudstone, volumetric dilation behaviour vanishes gradually with an increase in damage degree, while it remains stable in the sandstone where the strain hardening behaviour is less obvious. Regarding acoustic emission (AE) characteristics, AE hit and AE energy show a similar evolutionary trend in the loading process. A sudden increase in AE energy is accompanied with drastic drop or local fluctuation in the load-bearing capacity of the rock while AE hit fails in predicting such variation in the load-bearing capacity. A quiet stage of AE signal prior to the peak stress is captured, which can be taken as a precursor for rock failure. Failure pattern of the coal, mudstone and sandstone varies from shear faulting to tension-shear mixed fracturing and then to axial splitting, which is in good accordance with that deduced from AE location analysis.
Novel email spam detection method using sentiment analysis and personality recognition
Authors: Ezpeleta Enaitz , Velez de Mendizabal Iñaki , Hidalgo José María Gómez , Zurutuza Urko 
Published: November 2019

AbstractUnsolicited email campaigns remain as one of the biggest threats affecting millions of users per day. During the past years several techniques to detect unsolicited emails have been developed. This work provides means to validate the hypothesis that the identification of the email messages’ intention can be approached by sentiment analysis and personality recognition techniques. These techniques will provide new features that improve current spam classification techniques. We combine personality recognition and sentiment analysis techniques to analyse email content. We enrich a publicly available dataset adding these features, first separately and after in combination, of each message to the dataset, creating new datasets. We apply several combinations of the best email spam classifiers and filters to each dataset in order to compare results.
A flexible logic-based approach to closeness using order of magnitude qualitative reasoning
Authors: Burrieza Alfredo , Muñoz-Velasco Emilio , Ojeda-Aciego Manuel 
Published: November 2019

Abstract
In this paper, we focus on a logical approach to the important notion of closeness, which has not received much attention in the literature. Our notion of closeness is based on the so-called proximity intervals, which will be used to decide the elements that are close to each other. Some of the intuitions of this definition are explained on the basis of examples. We prove the decidability of the recently introduced multimodal logic for closeness and, then, we show some capabilities of the logic with respect to expressivity in order to denote particular positions of the proximity intervals.
Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance
Authors: McNeill Daniel R , Whitaker Amy M , Stark Wesley J , Illuzzi Jennifer L , McKinnon Peter J , Freudenthal Bret D , Wilson David M 
Published: November 2019

Abstract
DNA is susceptible to a range of chemical modifications, with one of the most frequent lesions being apurinic/apyrimidinic (AP) sites. AP sites arise due to damage-induced (e.g. alkylation) or spontaneous hydrolysis of the N-glycosidic bond that links the base to the sugar moiety of the phosphodiester backbone, or through the enzymatic activity of DNA glycosylases, which release inappropriate bases as part of the base excision repair (BER) response. Unrepaired AP sites, which lack instructional information, have the potential to cause mutagenesis or to arrest progressing DNA or RNA polymerases, potentially causing outcomes such as cellular transformation, senescence or death. The predominant enzyme in humans responsible for repairing AP lesions is AP endonuclease 1 (APE1). Besides being a powerful AP endonuclease, APE1 possesses additional DNA repair activities, such as 3′–5′ exonuclease, 3′-phophodiesterase and nucleotide incision repair. In addition, APE1 has been shown to stimulate the DNA-binding activity of a number of transcription factors through its ‘REF1’ function, thereby regulating gene expression. In this article, we review the structural and biochemical features of this multifunctional protein, while reporting on new structures of the APE1 variants Cys65Ala and Lys98Ala. Using a functional complementation approach, we also describe the importance of the repair and REF1 activities in promoting cell survival, including the proposed passing-the-baton coordination in BER. Finally, results are presented indicating a critical role for APE1 nuclease activities in resistance to the genotoxins methyl methanesulphonate and bleomycin, supporting biologically important functions as an AP endonuclease and 3′-phosphodiesterase, respectively.
Considerations for a surgical RCT for diffuse low-grade glioma: a survey
Authors: Mansouri Alireza , Brar Karanbir , Cusimano Michael D 
Published: November 2019

AbstractBackgroundDiffuse low-grade gliomas (DLGGs) are heterogeneous tumors that inevitably differentiate into malignant entities, leading to disability and death. Recently, a shift toward up-front maximal safe resection of DLGGs has been favored. However, this transition is not supported by randomized controlled trial (RCT) data. Here, we sought to survey the neuro-oncology community on considerations for a surgical RCT for DLGGs.MethodsA 21-question survey focusing on a surgical RCT for DLGGs was developed and validated by 2 neurosurgeons. A sample case of a patient for whom management might be debatable was presented to gather additional insight. The survey was disseminated to members of the Society for Neuro-Oncology (SNO) and responses were collected from March 16 to July 10, 2018.ResultsA total of 131 responses were collected. Sixty-three of 117 (54%) respondents thought an RCT would not be ethical, 39 of 117 (33%) would consider participating, and 56 of 117 (48%) believed an RCT would be valuable for determining the differing roles of biopsy, surgery, and observation. This was exemplified by an evenly distributed selection of the latter management options for our sample case. Eighty-three of 120 (69.2%) respondents did not believe in equipoise for DLGG patients. Quality of life and overall survival were deemed equally important end points for a putative RCT.ConclusionsBased on our survey, it is evident that management of certain DLGG patients is not well defined and an RCT may be justified. As with any surgical RCT, logistic challenges are anticipated. Robust patient-relevant end points and standardization of perioperative adjuncts are necessary if a surgical RCT is undertaken.
Embracing Religious Freedom?: A Battle Over Public School Prayer in the USA and Japan
Authors: Yokotsuka Shino 
Published: November 2019

Abstract
This article examines why the USA and Japan have different public reactions to the issues of public school prayer, despite the fact that the countries have almost identical constitutional frameworks on religious freedom. Recent religious freedom studies tend to centre around the debates that prioritize Western perspectives of religion in public schools. In contrast, this article focuses on the specific social and cultural contexts emphasizing their importance in understanding the governance issues arising from an ever-widening religious gap. This study particularly addresses the role cultural differences play in the unequal interpretations of religious freedom within different national backgrounds. Using a comparative case study analysis, I argue that these cultural differences directly impact the varying perspectives on religious freedom as applied in policy, law, and practice across the countries.
Rewards Enhance Proactive and Reactive Control in Adolescence and Adulthood
Authors: Magis-Weinberg Lucía , Custers Ruud , Dumontheil Iroise 
Published: November 2019

Abstract
Cognitive control allows the coordination of cognitive processes to achieve goals. Control may be sustained in anticipation of goal-relevant cues (proactive control) or transient in response to the cues themselves (reactive control). Adolescents typically exhibit a more reactive pattern than adults in the absence of incentives. We investigated how reward modulates cognitive control engagement in a letter-array working memory (WM) task in 30 adolescents (12–17 years) and 20 adults (23–30 years) using a mixed block- and event-related functional magnetic resonance imaging design. After a Baseline run without rewards, participants performed a Reward run where 50% trials were monetarily rewarded. Accuracy and reaction time (RT) differences between Reward and Baseline runs indicated engagement of proactive control, which was associated with increased sustained activity in the bilateral anterior insula (AI), right dorsolateral prefrontal cortex (PFC) and right posterior parietal cortex (PPC). RT differences between Reward and No reward trials of the Reward run suggested additional reactive engagement of cognitive control, accompanied with transient activation in bilateral AI, lateral PFC, PPC, supplementary motor area, anterior cingulate cortex, putamen and caudate. Despite behavioural and neural differences during Baseline WM task performance, adolescents and adults showed similar modulations of proactive and reactive control by reward.
The atypical lymphocyte count: a novel predictive factor for severe thrombocytopenia related to dengue
Authors: Abeysuriya Visula , Choong Clarice Shi Hui , Thilakawardana Basuru Uvindu , de Mel Primesh , Shalindi Malka , de Mel Chandima , Chandrasena Lal , Seneviratne Suranjith L , Yip Christina , Yap Eng-Soo , de Mel Sanjay 
Published: November 2019

Abstract

Background
Early identification of patients at risk of severe dengue disease (DD) is critical to guide its management. We evaluated whether the atypical lymphocyte count (ALC), generated from the Sysmex automated full blood count analyzer, is predictive of severe thrombocytopenia secondary to Dengue infection.

Methods
We prospectively collected data on patients admitted with DD between December 2017 and October 2018. ALC data were extracted from the Sysmex XS500i analyzer from day 1 to day 7 of admission. Clinical data were obtained from patients' medical records.

Results
We enrolled 256 patients with DD. A negative correlation between ALC on admission and platelet count on day 5 to day 7 (Spearmen's correlation; day 5:-0.485, day 6:-0.428 and day 7:-0.344) (p=0.001) was observed. Based on receiver operator characteristic curve analysis, we found that an ALC of &gt;0.5x103/L had 90% sensitivity and 70% specificity for severe thrombocytopenia (platelet count &lt;50x109/L) on day 5. The positive and negative predictive values were 74.4 and 91.2%, respectively (power 84.7).

Conclusions
We propose that ALC on admission may be a novel negative predictive factor for severe thrombocytopenia on day 5 to day 7 of DD. Further studies are required to validate our findings and evaluate whether ALC is predictive of other complications of DD.
Circulatory support during lung transplantation
Authors: Kiziltug Hannah , Falter Florian 
Published: November 2019

Purpose of review
Lung transplantation can be performed off-pump, with sequential one-lung ventilation, or using mechanical circulatory support (MCS). MCS can either be in the form of cardiopulmonary bypass (CPB) or veno-arterial or veno-venous extracorporeal membrane oxygenation (VA ECMO or VV ECMO).
This article reviews the indications, benefits and limitations of these different techniques and evaluates their effect on outcomes.

Recent findings
Recently, there has been a shift toward intraoperative ECMO support and away from CPB. The first results of this strategy are promising. The use of intraoperative ECMO with the possibility of prolongation of MCS into the postoperative period has been shown to lead to improved survival when compared with lung transplants not receiving ECMO. Recipients of organs from extended criteria donors show encouraging survival rates when the lungs are reperfused using MCS. A recent metaanalysis comparing ECMO versus CPB showed favourable outcomes supporting the use of ECMO despite not finding a difference in mortality between the two methods.

Summary
The trend toward ECMO and away from cardiopulmonary bypass is backed up with good survival rates. However, to date, there has not been a randomized controlled trial to further guide the choice of MCS strategy for lung transplantation.
How to communicate between surgeon and intensivist?
Authors: Misseri Giovanni , Cortegiani Andrea , Gregoretti Cesare 
Published: November 2019

Purpose of review
Communication and teamwork are essential to enhance the quality of care, especially in operating rooms and ICUs. In these settings, the effective interprofessional collaboration between surgeons and intensivists impacts patients’ outcome. This review discusses current opinions and evidence for improving communication strategies and the relationship between surgeons and intensivists/anesthesiologist.

Recent findings
Effective teamwork has been demonstrated to improve patient outcome and foster healthier relationships between professionals.
With the expansion of new medical superspecialist disciplines and the latest medical developments, patient care has been put through a progressive fragmentation, rather than a holistic approach. Operating theaters and ICU are the common fields where surgeons and anesthesiologists/intensivists work. However, communication challenges may frequently arise. Therefore, effective communication, relational coordination, and team situation awareness are considered to affect quality of teamwork in three different phases of the patient-centered care process: preoperatively, intraoperatively, and postoperatively.

Summary
Although limited, current evidence suggests to improve communication and teamwork in patient perioperative care. Further research is needed to strengthen the surgeon–intensivist relationship and to deliver high-quality patient care.