bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adsorptive removal of gallic acid from aqueous solution onto magnetic ion exchange resin
Authors: Ding Lei , Guo Changjin , Zhu Yunhua , Ma Jiangya , Kong Yanli , Zhong Meiying , Cao Qiongxi , Zhang Huiwen 
Published: June 2020

Abstract
Finding an appropriate adsorbent with high adsorption capacity, quick adsorption kinetics and easy regeneration was crucial to the removal of gallic acid (GA) from water and wastewater. Our aims were to investigate whether a magnetic ion exchange (MIEX) resin had the three merits mentioned above, and investigate the feasibility of GA adsorption on MIEX resin, and the adsorption kinetics, equilibrium, thermodynamics, regeneration and mechanism using batch tests. The uptake of GA increased with increasing GA concentration. The GA concentration influenced the time needed to reach equilibrium, but the adsorption could be completed within 120 min. Elevating temperature facilitated the GA removal. The removal percent remained above 95.0% at pH 5.0–11.0. Carbonate and bicarbonate promoted the GA removal; conversely chloride, sulfate and nitrate restrained the GA removal significantly. The adsorption kinetics could be fitted well with the pseudo second-order model, and the film diffusion governed the whole adsorption rate. The equilibrium data followed the Redlich–Peterson isotherm model. The adsorption was a spontaneous, endothermic and entropy driven process. The ion exchange dominated the removal mechanism. The spent MIEX resin was well regenerated by sodium chloride. Therefore, MIEX resin is a potential adsorbent for removing GA quickly and efficiently from water and wastewater.
Development of mesh-type Fenton-like Cu/Fex/γ-Al2O3/Al catalysts and application for catalytic degradation of dyes
Authors: Qian Huang , Qianwen Shao , Qi Zhang , Yanhui Ni , Yongqiang Wu 
Published: June 2020

Abstract
The application of nanoparticle heterogeneous Fenton-like catalysts is limited due to the requirement of filtration after reaction and possible secondary pollution. In this work, a novel mesh-type monolithic Fenton-like Cu/Fex/γ-Al2O3/Al catalyst was developed for the degradation of dyes. The Cu and Fe species are uniformly dispersed on the mesh-type anodic monolithic γ-Al2O3 supports, and the results of scanning electron microscopy and X-ray diffractometry analysis show that Fe can reduce the particle size of Cu over γ-Al2O3. The activity results show that the degradation rate of rhodamine B (RhB) reached 99.5% within 1 h using 4 × 6 cm Cu12.0/Fe2.0/γ-Al2O3/Al catalyst with 1,200 ppm H2O2 at 50 °C. The important role of •OH as a reactive oxidant was confirmed through electron spin-resonance spectroscopy and radical scavenging experiment. The hydrogen temperature programmed reduction suggests the high redox ability of Cu/Fe bimetallic catalyst is beneficial to the production of •OH. The Cu/Fe bimetallic catalyst shows excellent recyclability in a 10-cycle experiment, the degradation rate of RhB was maintained at 98% and the leaching amount of metals was lower than 0.7 mg/L. The mesh-type catalyst will be easily applied for the continuous wastewater treatment because it does not need filtration for recovery.
Emerging Proof of Protein Misfolding and Interactions in Multifactorial Alzheimer's Disease
Authors: Uddin Md. Sahab , Al Mamun Abdullah , Rahman Md. Ataur , Behl Tapan , Perveen Asma , Hafeez Abdul , Bin-Jumah May N. , Abdel-Daim Mohamed M. , Ashraf Ghulam Md 
Published: June 2020

Objective:
Alzheimer's disease (AD) is a devastating neurodegenerative disorder, characterized
by the extracellular accumulations of amyloid beta (Aβ) as senile plaques and intracellular aggregations
of tau in the form of neurofibrillary tangles (NFTs) in specific brain regions. In this review, we
focus on the interaction of Aβ and tau with cytosolic proteins and several cell organelles as well as associated
neurotoxicity in AD.

Summary:
Misfolded proteins present in cells accompanied by correctly folded, intermediately folded,
as well as unfolded species. Misfolded proteins can be degraded or refolded properly with the aid of
chaperone proteins, which are playing a pivotal role in protein folding, trafficking as well as intermediate
stabilization in healthy cells. The continuous aggregation of misfolded proteins in the absence of
their proper clearance could result in amyloid disease including AD. The neuropathological changes of
AD brain include the atypical cellular accumulation of misfolded proteins as well as the loss of neurons
and synapses in the cerebral cortex and certain subcortical regions. The mechanism of neurodegeneration
in AD that leads to severe neuronal cell death and memory dysfunctions is not completely understood
until now.

Conclusion:
Examining the impact, as well as the consequences of protein misfolding, could help to
uncover the molecular etiologies behind the complicated AD pathogenesis.
Evidence on the New Drug Lumateperone (ITI-007) for Psychiatric and Neurological Disorders
Authors: Mazza Marianna , Marano Giuseppe , Traversi Gianandrea , Sani Gabriele , Janiri Luigi 
Published: June 2020

:
Lumateperone (ITI-007) is a tosylate salt with binding affinities to receptors implicated in
the therapeutic actions of antipsychotic medications, including the serotonin 5HT2A receptors, dopamine
D2 and D1 receptors and the serotonin transporter. It has a unique mechanism of action because it
simultaneously modulates serotonin, dopamine, and glutamate neurotransmission, implicated in serious
mental illness. It can be considered a multi-target-directed ligand and a multifunctional modulator
of serotoninergic system with possible precognitive, antipsychotic, antidepressant and anxiolytic properties.
Lumateperone has been investigated as a novel agent for the treatment of schizophrenia, but it
represents a new potential option for other psychiatric and neurological diseases, such as behavioural
symptoms of dementia or Alzheimer’s disease, sleep disturbances, bipolar depression. Besides, it has
demonstrated a favourable safety profile without significant extrapyramidal side effects, hyperprolactinemia
or changes in cardiometabolic or endocrine factors versus placebo. Additional studies are warranted
to confirm and examine the benefit of lumateperone and possible therapeutic targets. This paper
is a comprehensive and thorough summary of the most important findings and potential future role of
this particular compound in personalized treatments.
Positive Correlation between Circulating Fetuin-A and Severity of Coronary Artery Disease in Men
Authors: Afrisham Reza , Paknejad Maliheh , Ilbeigi Davod , Sadegh-Nejadi Sahar , Gorgani-Firuzjaee Sattar , Vahidi Mahmoud 
Published: June 2020

Objective:
Fetuin-A serves a dual function; its high levels are associated with metabolic
syndrome, type 2 diabetes, obesity, insulin resistance, and nonalcoholic fatty liver disease, and on the
other hand, it serves as a potent inhibitor of ectopic vascular calcification. Due to the opposing findings,
the aim of the current study was to investigate serum fetuin-A levels in men with coronary artery
disease (CAD).

Methods:
In the case-control study, anthropometric and biochemical parameters were determined in 83
men (43 CAD patients and 40 control subjects). At last, the serum fetuin-A levels were measured using
the fetuin-A human enzyme-linked immunosorbent assay (ELISA) kit.

Results:
A significant difference was detected among the two groups for triglyceride and cholesterol
levels (P=0.003 and P=0.002, respectively). The mean fetuin-A levels were determined 230.57 ± 63.76
and 286.35 ± 64.07 μg/ml for the control group and the CAD patients, respectively (P<0.001). Fetuin-
A was significantly correlated to the severity of CAD (r 0.393, P<0.001) and associated with the risk
of CAD in subjects (OR [CI] = 1. 144 [1.060-1. 235]; p = 0.001). A cut-off value of 237.4 μg/ml had
good sensitivity (76.7%) and specificity (65.0%) for differentiating between two groups [area under
curve (AUC) = 0.732 (CI=0.621-0.842); p < 0.001].

Conclusion:
Our results indicated that fetuin-A levels were positively correlated to the severity of
CAD. The findings suggest that there is a possible link between pathogenic mechanisms of atherosclerosis
and fetuin-A; however, more investigations are needed in this regard.
Global Trends of Computational Fluid Dynamics to Resolve Real World Problems in the Contemporary Era
Authors: Gupta Nikita , Bhardwaj Nishant , Khan Gulam Muhammad , Dave Vivek 
Published: June 2020

Background:
Computational fluid dynamics (CFD) came into existence with great success,
thereby replacing the traditional methods used to simulate the problems related to the flow of fluid.
First CFD utilitarian was introduced to the world in 1957, which was developed by a team at Los
Alamos National Lab. For tremendous performance and to meet the expected results with ease for
modern process conditions, engineers are now more inclined towards the use of simulation software
rather than traditional methods. Hence, in the current scenario with the advancement of computer
technologies, “CFD is recognized as an excellent tool for engineers to resolve real-world problems.”

Introduction:
CFD is defined as a branch of fluid dynamics which involves the use of numerical analysis
and data structure to solve complications related to the flow of fluids (gasses or liquids). CFD is
based on three major principles that are mass conservation, Newton's second law, and energy conservation.
CFD has extended to a number of applications at an alarming rate in every field such as in aerospace,
sports, food industry, engineering, hydraulics, HVAC (Heating, Ventilating, and Air conditioning),
automotive, environmental, power generation, biomedical, pharmaceutical, and many more.
Hence, a number of software like ANSYS, Open Foam, SimScale, Gerris, Auto desk simulation,
Code_Saturne, etc, are beneficial in order to execute the operations, and to find the solution of realworld
problems within a fraction of seconds.

Methods:
CFD analysis involves three major steps; pre-processing, solution, and post-processing. Preprocessing
deals with defining model goals, identification of domain, designing, and creating the grid.
Solution involves setting up the numerical model, computing, and monitoring the solution; whereas,
post-processing includes results of the examination and revision of the model.

Results:
The review includes current challenges about the computational fluid dynamics. It is relevant
in different areas of engineering to find answers for the problems occurring globally with the aid of a
number of simulation-based software hereby, making the world free from complex problems in order
to have a non-complicated scenario.

Conclusion:
Computational fluid dynamics are relevant in each, and every kind of problem related to
the fluid flow, either existing in the human body or anywhere. In the contemporary era, there are
enormous numbers of simulation-based software, which provide excellent results with just one click,
thereby resolving the problems within microseconds. Hence, we cannot imagine our present and upcoming
future without CFD, which has ultimately made the execution of work easier, leaving behind
non-complicating scenarios. Lastly, we can conclude that “CFD is a faster, smarter, and lighter way in
designing process.”
Contributing to Elimination of Cross-Border Malaria Through a Standardized Solution for Case Surveillance, Data Sharing, and Data Interpretation: Development of a Cross-Border Monitoring System
Authors: Saldanha Raphael , Mosnier Émilie , Barcellos Christovam , Carbunar Aurel , Charron Christophe , Desconnets Jean-Christophe , Guarmit Basma , Gomes Margarete Do Socorro Mendonça , Mandon Théophile , Mendes Anapaula Martins , Peiter Paulo César , Musset Lise , Sanna Alice , Van Gastel Benoît , Roux Emmanuel 
Published: June 2020

Background
Cross-border malaria is a significant obstacle to achieving malaria control and elimination worldwide.

Objective
This study aimed to build a cross-border surveillance system that can make comparable and qualified data available to all parties involved in malaria control between French Guiana and Brazil.

Methods
Data reconciliation rules based on expert knowledge were defined and applied to the heterogeneous data provided by the existing malaria surveillance systems of both countries. Visualization dashboards were designed to facilitate progressive data exploration, analysis, and interpretation. Dedicated advanced open source and robust software solutions were chosen to facilitate solution sharing and reuse.

Results
A database gathering the harmonized data on cross-border malaria epidemiology is updated monthly with new individual malaria cases from both countries. Online dashboards permit a progressive and user-friendly visualization of raw data and epidemiological indicators, in the form of time series, maps, and data quality indexes. The monitoring system was shown to be able to identify changes in time series that are related to control actions, as well as differentiated changes according to space and to population subgroups.

Conclusions
This cross-border monitoring tool could help produce new scientific evidence on cross-border malaria dynamics, implementing cross-border cooperation for malaria control and elimination, and can be quickly adapted to other cross-border contexts.
MINIMALLY INVASIVE TOTAL ESOPHAGECTOMY IN ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA
Authors: Jeri Sebastian , Pagan-Pomar Alberto , Martínez-Córcoles Jose Antonio , Bianchi Alessandro , Alvarez-Segurado Cristina , Pujol-Cano Natalia , Gil-Catalán Alejandro , González-Argente Francesc Xavier 
Published: June 2020

The treatment of oesophageal cancer has undergone a change with the progress of minimally invasive surgery. The morbidity and mortality rates of patients who undergo minimally invasive esophagectomy are dropping. We present the case of a 60-year-old patient with distal oesophageal adenocarcinoma who underwent minimally invasive total esophagectomy.

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Modern Athens: Migration Processes and Paradigms of Urban Development
Authors: Kvashnin Y. D. 
Published: June 2020

This article attempts to assess the role of migration processes in the urban development of Athens over an extended period of time – since 1834, when the city became the capital of an independent Greek state, up to this day. The history of modern Athens, which in less than a century has turned from a small regional center into one of the ten largest urban agglomerations in the European Union, is a peculiar case of Mediterranean-type spontaneous urbanization with all its drawbacks, such as illegal construction, excessively high population density and infrastructural problems. At the turn of the 20th century Athens faced a new challenge – the mass inflow of immigrants from the former Yugoslavian countries and Albania, and after Greece entered the Schengen zone – from the countries of North Africa, the Middle East and South Asia. During the 2015 migration crisis, Greece became the main gateway for hundreds of thousands of refugees and economic migrants to the European Union. These trends have had a direct impact on the economy and social environment of the Greek capital, reinforcing challenges such as an increase in the number of low-income residents, ethnic segregation by regions and suburbanization – relocation of indigenous people from a dilapidated center to safer and more comfortable suburbs and satellite towns.The need for a transition to more responsible urban planning became apparent in the 1980s, when the first (to be legislated) master plan was adopted, which determined the development strategy for the manufacturing sector, transport system, land use and housing market policies. A serious incentive for the implementation of infrastructure projects – partially funded by EU structural funds – was the holding of the 2004 Olympic Games. In 2014, against the backdrop of a debt crisis and economic recession, the city administration adopted Athens Resilience Strategy for 2030, which takes into account such chronic problems as infrastructure degradation, irregular migration, as well as poor management at the regional and prefectural levels. Presently, due to the lack of necessary financial resources, a decisive role in improving the urban environment is assigned to the private sector. Thus, municipal authorities contribute to the gentrification of the central regions of Athens, which have got unfulfilled tourism and investment potential, providing significant tax benefits and incentives for doing business.
Latin America: Demographic Dynamics and the Migration Processes Transformation
Authors: Kudeyarova N. Yu. 
Published: June 2020

Latin America is one of the high level migration activity regions. The mass migration flows are the part of the Western Hemisphere South nations history for more than a century and a half. Both the structure and direction of that flows have been significantly transformed during that period. While being the transatlantic flows recipients at the end of the XIX – beginning of the XX centuries, the Latin American States turned into donors of human resources in the second half of the XX century due to the profound demographic transformation. The aim of this paper is to analyse the demographic transformations impact on the emigration mobility models development in Latin America and the Caribbean countries. Demographic changes were manifested in different ways in countries with a large share of European migrants and those that were not affected by mass migrations flows at the turn of the XIX – XX centuries. The Central America countries and Mexico have experienced the most profound population explosion that subsequently affected the intensity of the migration movement to the United States. The paper examines the main migration directions of Latin America and the Caribbean residents, identifies two basic mobility source areas that demonstrate different strategies via different destination countries choice. While the United States has become the leading destination country for Latin American migrants, accounting for 93% of migrants from Central America and Mexico, the South American migration is mostly intraregional. The largest regional integration associations migration policies implementation reflects this difference. Spain has become a significant extra-regional migration destination for South America. At the end of the second decade of the XXI century, global economic transformations affect the migration dynamics of Latin American subregions, producing powerful migration crises and local tensions.
The Dynamics of the Day and Night Population as an Indicator of Structural and Functional Changes in the Territory of the City in the Zone of Influence of the Moscow Central Ring Using Data from Mobile Operators
Authors: Makhrova A. G. , Babkin R. A. , Kazakov E. E. 
Published: June 2020

Moscow as a world city combines territories with various functional content. At the same time, the complexity of the morphological structure of the capital is supplemented by the high dynamism of the socio-economic processes taking place in it. In this context, an important task is to assess the role of large infrastructure projects, intensifying the processes of transformation of the urban structure and in a short time changing the historically established functional roles of vast urban spaces. The article uses the data of mobile operators to analyze functional changes in the zone of influence of the largest urban megaproject – the Moscow Central Ring (MCC) from 2015 to 2018. The available information on mobile telephony about the distribution of the population at night and daytime allows us to characterize the degree of “dormancy” and “attractiveness” of urban areas near the MCC, and accordingly their functional roles. The analysis showed that during the period under review, the day and night population of 43 municipalities surrounding the MCC showed an equal increase of 0.35 million people with a significant differentiation of its pace in certain areas. The ratio between the day and night population of the areas, as well as its change from 2015 to 2018 allowed to distinguish the characteristic functional types of districts. The typology demonstrated that the role of the MCC in spatial development for the attractive territories of the center and subcenter of Moscow turned out to be significantly less noticeable than for areas located on the side of the MCC external to the city center. This influence was more replaceable in municipalities, where the railway ring became the first type of high-speed off-street transport, as well as in areas that have significant areas of industrial zones, the majority of the observed structural and functional movements in urban morphology are associated with the synergy of renovation.
ANALYSIS OF CAUSATIVE FACTORS FOR CANKER DISEASE EPIDEMIC ON RUBBEr PLANTS IN SOUTH SUMATRA
Authors: Febbiyanti Tri Rapani , Wiyono Suryo , Yahya Sudirman , Widodo Widodo 
Published: June 2020

Analysis of Causative Factors for Canker Disease Epidemic on Rubber Plants in South Sumatra. Lasiodiplodia theobromae is the cause of stem canker in the rubber plant (Hevea brasiliensis), this is a new disease and has never been reported in Indonesia. Currently, data on environmental factors and cultivation techniques related to the development of stem canker are not available so research needs to be done on this subject. The objective of the study was to analyze environmental factors and cultivation techniques related to stem canker on rubber trees in southern Sumatra. The study was conducted by collecting data on environmental factors and cultivation techniques and then analyzed the association with stem canker. Field observation was carried out at 21 locations in PT. Perkebunan Nusantara VII Business Unit Padang Plawi Bengkulu, Tulung Buyut Lampung, Musilandas Palembang and Experimental Garden of Sembawa Research Center, Indonesian Rubber Research Institute at Palembang to measure the severity and incidence of this disease. Besides that, the data of cultivation technique and the condition of the garden were taken from the officer at those locations. Soil sample from each location was taken in a composite way, then its physical and chemical components were analyzed. The analysis was conducted to find out the correlation between cultivation and disease severity using chi-square test. The relationship between chemical and physical factors of the soil with the disease severity was analyzed using a multivariate test of principal component analysis/PCA. Regression analysis was conducted to show the possible relation to the incidence and severity of this disease. The location, clones, weed control and the number of plants per hectare showed a correlation with the disease severity. There was a positive correlation between incidence and severity of the disease. The highest disease severity occurred at the Sembawa location on clone BPM 24, with the number of plant population per ha was ≥ 555 trees and weed control using herbicide. Content of soil nitrogen, dust, clay and water as well as cation exchange capacity (CEC)were suggested to significantly contribute to the severity of stem canker.