bluuebunny/crossref_metadata_2025_split huggingface dataset:
Freiheit unter Bedingungen der Zeit? Schellings neuer Zeitbegriff im Nachgang zurFreiheitsschrift
Authors: Buchheim Thomas 
Published: June 2020

AbstractThe concept of human freedom developed by Schelling in the Freiheitsschrift (1809) prompted him to explore a new concept of time in his Weltalter project. Schelling proposes the ‘generic subjectivity of time’: Time must be understood not as a precondition of dynamism, but rather as an effect of dynamic agency. The articulation of time into its moments, ‘presence’, ‘past’, and ‘future’, is realized through the dynamic contributions (motion, causality, and action) of every single causally involved being. Schelling’s concept thus fundamentally differs from Kant’s concept of time. For Kant, change and dynamism are located in the sensible world, whereas time (as well as space) is the subjective form of our sensible intuition. As such, time must be seen as a precondition of change and dynamism for Kant.
microRNA-491-5p protects against atherosclerosis by targeting matrix metallopeptidase-9
Authors: He Zhonghan , Wang Yayun , He Qin , Chen Manhua 
Published: June 2020

Abstract
Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are critical processes that are involved in atherosclerosis. The aim of this study was to explore the role of microRNA-491-5p (miR-491-5p) in the progression of atherosclerosis by regulating the growth and migration of VSMCs. In this study, we showed that the expression of miR-491-5p was downregulated in the atherosclerotic plaque tissues and plasma samples of the patients with atherosclerosis. The bioinformatic analysis and dual-luciferase reporter assay identified that matrix metallopeptidase-9 (MMP-9) was a target gene of miR-491-5p. The results showed a significant upregulation of MMP-9 in the atherosclerotic plaque tissues and plasma samples. Subsequently, the results also showed that downregulation of miR-491-5p significantly promoted the proliferation and migration of VSMCs and inhibited the apoptosis in VSMCs. Furthermore, we detected the effects of miR-491-5p mimic on the growth and migration of VSMCs, and the results illustrated that miR-491-5p mimic could inhibit the proliferation and migration of VSMCs and promote the apoptosis of VSMCs. Notably, MMP-9 plasmid could reverse all the effects of miR-491-5p mimic on VSMCs. Collectively, our study provides the first evidence that miR-491-5p inhibited the growth and migration of VSMCs by targeting MMP-9, which might provide new biomarkers and potential therapeutic targets for atherosclerosis treatment.
Nordkoreas Cyber-Krieg Strategie: Kontinuität und Wandel
Authors: Raska Michael 
Published: June 2020

Zusammenfassung
Nach Auffassung Pjöngjangs ist die koreanische Halbinsel Schauplatz eines eingefrorenen geopolitischen Konflikts zwischen Großmächten. Die Vereinigten Staaten betreiben dabei eine aus Sicht des nordkoreanischen Regimes „feindselige Politik“, die dessen Überleben gefährde und den politischen Gestaltungsraum sowie das wirtschaftliche Entwicklungspotenzial des Landes untergrabe. Während Südkorea und den Vereinigten Staaten vor allem das wachsende Kernwaffenarsenal und die zunehmenden ballistischen Raketenfähigkeiten Nordkoreas Sorgen bereiten, sollte das Bündnis auch der stetigen Weiterentwicklung der nordkoreanischen – offensiven und defensiven – Cyberfähigkeiten mehr Aufmerksamkeit schenken. Nordkorea strebt nach strategischer Überlegenheit, indem es kostengünstige, asymmetrische militärische Fähigkeiten einschließlich Cyberstrategien entwickelt, um Informationen zu sammeln, seine Rivalen unter Druck zu setzen, andere finanziell zu erpressen und auf anderem Wege Einfluss in einer Weise auszuüben, gegen die herkömmliche Abschreckungs- und militärische Gegenmaßnahmen wirkungslos sind. Seoul und Washington benötigen eine umfassende militärische Einsatzstrategie gegen das gesamte Spektrum potenzieller nordkoreanischer Provokationen, während europäische Staaten ihre Cybersicherheitsstrategien verstärken müssen, um die zunehmenden globalen Cyberoperationen Nordkoreas verlässlich aufzuspüren und abzuwehren.
ÜNİVERSİTE ÖĞRENCİLERİNİN MANEVİ YÖNELİMLERİ VE SAĞLIK ALGILARI
Authors: KÖKTÜRK DALCALI Berna 
Published: June 2020

Giriş: Gençlik döneminin bir parçası olan üniversite yaşamı öğrenciler için kendi rutinleri ve yaşam alışkanlıklarında ki birçok değişikliği beraberinde getirmektedir. Maneviyat öğrencilerin karşılaştıkları ve kontrol altına alamadıkları bu zorlukların aşılmasında önemli bir başa çıkma mekanizmasıdır. Manevi yönelim bireyi sevgi, anlam, huzur, umut, esenlik ve bütünlük gibi sağlıkla ilişkili birçok kavramada yönlendirmektedir. Yöntem: Araştırma tanımlayıcı-ilişki arayıcı bir çalışmadır. Araştırmanın evrenini bir meslek yüksekokulunda I. ve II. Öğretimde öğrenimlerine devam eden 2160 öğrenci oluşturmuştur ve araştırma 250 öğrenci ile tamamlanmıştır. Verilerin toplanmasında araştırmacı tarafından literatür doğrultusunda geliştirilen ‘Yapılandırılmış Kişisel Bilgi Formu’, ‘Manevi Yönelim Ölçeği’ ve ‘Sağlık Algısı Ölçeği’ kullanılmıştır. Verilerin istatistiksel analizi için SPSS 21.0 Paket programı kullanılmıştır. Bulgular: Öğrencilerin manevi yönelim puanlarının 92,62±23,31 olduğu görüldü ve manevi yönelimlerinin yüksek olduğu görüldü. Kontrol merkezi alt boyutundan 14,59±2,84; Kesinlik alt boyutundan 11,36±2,16; sağlığın önemi alt boyutundan 6,97±2,66; öz farkındalık alt boyutundan 6,85±2,35 ve sağlık algısı ölçeği toplamından 39,78±5,46 puan aldıkları görüldü. Manevi yönelim yükseldikçe kontrol merkezi (p:0,033); kesinlik (p:0,003); öz farkındalık (p:0,015) alt boyutlarının puanlarının yükseldiği; sağlığın önemi alt boyutunun puanının ise düştüğü görüldü(p:0,000). Sonuç: Öğrencilerin manevi yönelimleri ve sağlık algısı ölçeğinin alt boyutları arasında anlamlı bir ilişki mevcutken sağlık algısı toplam puanının manevi yönelimle ilişkili olmadığı görüldü. Manevi yönelimin kontrol merkezi, kesinlik ve öz farkındalık alt boyutlarını olumlu etkilediği düşünüldüğünde öğrencilerin sağlık algılarının yükseltilmesinde manevi kaynakları kullanılabilir.
Manual para Elaboração e Apresentação de Trabalhos Acadêmicos: projeto, monografia, dissertação e artigo
Authors: Siena Osmar , Oliveira Clésia Maria de , Braga Aurineide Alves 
Published: June 2020

Um trabalho científico exige uma estrutura bem definida que integre as partes que o compõe, bem como o correto uso dos padrões da norma científica adotada. Neste sentido, o objetivo deste Manual é apresentar e discutir os tipos, a estrutura e as normas de elaboração e formatação de trabalhos acadêmicos com base nas orientações da Associação Brasileira de Normas Técnicas (ABNT). De forma complementar traz uma síntese das normas da sétima edição do Manual de Publicação da American Psychological Association (APA). A elaboração de trabalhos acadêmicos requer o desenvolvimento de competências teóricas e habilidades técnicas, bem como a observância de aspectos essenciais no que diz respeito a estruturação. Os assuntos discutidos neste Manual focam nos trabalhos mais comuns na vida acadêmica e visam oferecer subsídios à produção escrita, considerando que entre as finalidades da graduação e pós-graduação está o domínio das técnicas da produção científica. Durante várias décadas, a forma de organização e apresentação de trabalhos acadêmicos ou científicos no Brasil foi caracterizada por uma variedade de orientações de diversas fontes: normas de publicações científicas internacionais, comitês ou conselhos de áreas específicas, dados do Instituto Brasileiro de Bibliografia e Documentação (IBBD) e orientações da ABNT. De modo semelhante algumas instituições acadêmicas e periódicos, em função de suas autonomias, exigem normas específicas para publicação de trabalhos acadêmicos, embora haja uma tendência cada vez maior em uniformizar os procedimentos seguindo as orientações da ABNT. A dispersão causa certos dissabores para orientandos e orientadores. Não são poucos os estudantes e profissionais que, mesmo tendo um trabalho nas mãos, encontram dificuldades em prepará-lo adequadamente para submissão a uma banca examinadora ou periódico científico. Neste sentido uma das contribuições deste Manual consiste em reunir as principais orientações da ABNT, edições atualizadas, em único documento, além de contemplar a discussão sobre os tipos de trabalho acadêmico, seus elementos e características.
Analyse Exploratrice Des ModÃ¨les De RÃ©fÃ©rence De Lâ€™Ã©valuation De La Performance De La Chaine Logistique
Authors: Elgharbaoui M. 
Published: June 2020

Lâ€™intÃ©rÃªt pour lâ€™Ã©valuation de la performance de la chaine logistique a considÃ©rablement augmentÃ© au cours des trois derniÃ¨res dÃ©cennies avec de multiples recherches menÃ©es. Cet article veut examiner les modÃ¨les de rÃ©fÃ©rence (SCORÂ® , BSC, ECOGRAI et ABC) en mettant en Ã©vidence leurs apports et leurs limites dans lâ€™Ã©valuation de la performance de la chaine logistique. Ces modÃ¨les sont classÃ©s en trois approches principales : Approche axÃ©e sur les processus, approche axÃ©e sur les perspectives et approche axÃ©e sur les niveaux hiÃ©rarchiques. En effet, ces modÃ¨les reposent sur la conception dâ€™un systÃ¨me dâ€™indicateurs de performance multicritÃ¨res et multidimensionnels pour assurer la mesure de la performance et associent ses indicateurs Ã des activitÃ©s et Ã des centres de dÃ©cisionstout au long de la chaine logistique permettant une Ã©valuation de la performance. Cet article rÃ©vÃ¨le que les modÃ¨les exploitÃ©s sont fragilisÃ©s par leur incapacitÃ© Ã identifier les sources de performance et de non-performance dans la chaine logistique et par consÃ©quent leur insuffisance dans lâ€™Ã©laboration dâ€™un plan dâ€™action rÃ©sultant de lâ€™Ã©valuation de la performance de la chaine logistique. Ainsi, les contributions futures Ã la recherche sur lâ€™Ã©valuation des performances de la chaine de performance sont possibles et souhaitables pour surpasser les limites des modÃ¨les de rÃ©fÃ©rence actuels.
Interest in the topic of supply chain performance assessment has increased considerably over the last three decades and considerable research has been conducted in this area. The objective of this paper is to review the benchmark models (SCORÂ® , BSC, ECOGRAI and ABC) to highlight their contributions and limitations in the contribution of supply chain performance assessment. These models can be classified into three main approaches: process-based approach, perspective-based approach and hierarchical level approach. These models are based on the design of a system of multi-criteria and multidimensional performance indicators for performance measurement and link these indicators to activities and decision centres along the supply chain to enable performance assessment. This article reveals that the models used are weakened by their inability to identify the sources of performance and non-performance in the supply chain and consequently their inadequacies in the development of an action plan to result from the evaluation of supply chain performance. Thus, future contributions to research on supply chain performance assessment are possible and desirable to overcome the limitations of current benchmarking models.
Evaluation Des Connaissances Des Populations De La RÃ©gion De Nâ€™Zi Sur Lâ€™utilisation Des Plantes Alimentaires Dans Le Traitement Du DiabÃ¨te De Type 2, De Lâ€™hypertension ArtÃ©rielle Et De Lâ€™obÃ©sitÃ© (Centre-Est De La CÃ´te dâ€™Ivoire)
Authors: Kouakou Donthy Kouakoubah Richard , Piba Serge Cherry , Yao Konan , KonÃ© Mamidou Witabouna , Bakayoko Adama , Bi FÃ©zan Honora Tra 
Published: June 2020

Les maladies mÃ©taboliques et cardiovasculaires sont impliquÃ©es dans la survenue du syndrome mÃ©tabolique (SMet). Les plantes alimentaires peuvent Ãªtre une alternative importante dans leur prÃ©vention. Lâ€™objectif de ce travail est dâ€™Ã©valuer les connaissances des populations de la RÃ©gion du Nâ€™Zi qui se trouvent au Centre-Est de la CÃ´te dâ€™Ivoire. Ces diffÃ©rentes plantes alimentaires ont un bÃ©nÃ©fice santÃ© sur le diabÃ¨te de type 2, lâ€™hypertension artÃ©rielle et lâ€™obÃ©sitÃ©. Les enquÃªtes ethnobotaniques menÃ©es dans cette rÃ©gion, auprÃ¨s de 554 personnes, Ã lâ€™aide dâ€™un questionnaire dâ€™enquÃªte, ont permis de recenser 24 plantes alimentaires utilisÃ©es dans les mÃ©nages contre ces composantes du SMet. Parmi elles, Moringa oleifera (36,90 %) et Parkia biglobosa (25 %) sont les plus citÃ©es et les plus consommÃ©es. Les populations sâ€™accordent plus sur leur utilisation (FCI=0,91) pour traiter ces maladies endocriniennes nutritionnelles et mÃ©taboliques (diabÃ¨te de type 2 et obÃ©sitÃ©). Les plantes recensÃ©es dans la prÃ©sente Ã©tude pourraient Ãªtre utilisÃ©es comme aliments fonctionnels dans la prÃ©vention du diabÃ¨te, de lâ€™hypertension artÃ©rielle et de lâ€™obÃ©sitÃ©.
Metabolic and cardiovascular diseases are implicated in the occurrence of metabolic syndrome (MetS). Edible plants may be an important alternative in their prevention. The objective of this work is to assess the knowledge of the populations of the N'Zi region in the central-eastern part of CÃ´te d'Ivoire. These different food plants have a health benefit on type 2 diabetes, arterial hypertension and obesity. The ethnobotanical surveys conducted in this region, involving 554 people, using a survey questionnaire, using a survey questionnaire, identified 24 food used in households against these components of MetS. Among them, Moringa oleifera (36.90%) and Parkia biglobosa (25%) are the most cited and most consumed. There is greater agreement on their use (ICF=0.91) to treat nutritional and metabolic endocrine diseases(type 2 diabetes and obesity). The plants identified in this study could be used as functional foods in the prevention of type 2 diabetes, arterial hypertension and obesity.
Incidence De Lâ€™herbicidage Dans Le DÃ©sherbage En Culture De Manioc Dans La RÃ©gion De La MÃ©, SudEst De La CÃ´te dâ€™Ivoire
Authors: A. F. Yapi , A. Gue , J. N. Kouakou , F. K. Kouame , J. Ipou Ipou 
Published: June 2020

La culture du manioc joue depuis longtemps un rÃ´le important dans la diversification des exploitations et lâ€™offre alimentaire en CÃ´te dâ€™Ivoire. Malheureusement, depuis la crise socio-politique de 2010 et lâ€™avÃ¨nement de la politique de la scolarisation des enfants de moins de 16 ans, la gestion parfaite de lâ€™enherbement dans cette spÃ©culation est devenue un problÃ¨me majeur. Cette Ã©tude vise Ã Ã©valuer lâ€™incidence de lâ€™utilisation des herbicides sur les caractÃ©ristiques socio-Ã©conomiques du producteur de manioc en CÃ´te dâ€™Ivoire. La collecte des donnÃ©es sâ€™est faite en deux Ã©tapes. La premiÃ¨re a consistÃ© Ã effectuer une enquÃªte auprÃ¨s des producteurs de manioc dans la rÃ©gion de la MÃ©, situÃ© au Sud-Est du pays et la seconde, Ã rÃ©aliser une expÃ©rimentation avec un herbicide Ã base dâ€™oxyfluorfÃ¨ne sur la variÃ©tÃ© Â« bocou 1 Â» de manioc. Lâ€™enquÃªte rÃ©alisÃ©e relÃ¨ve que la technique de dÃ©sherbage influe sur la gestion de lâ€™enherbement et sur le profil du producteur. La technique manuelle est la plus pratiquÃ©e avec plus 85,44 p.c. Lâ€™expÃ©rimentation a montrÃ© que le dÃ©sherbage chimique couplÃ© au sarclage avec la machette est le mode de gestion de lâ€™enherbement le plus bÃ©nÃ©fique. Un producteur moyen met en moyenne 28 jours pour sarcler un hectare avec la daba, alors que pour le dÃ©sherbage chimique, une journÃ©e et demi-journÃ©e suffise. Sâ€™agissant du coÃ»t des dÃ©sherbages, le couplage de la technique chimique et la mÃ©thode manuelle est le moins coÃ»teux.
Cassava cultivation has long time played an important role in the diversification of farms and the food supply in CÃ´te dâ€™Ivoire. Unfortunately, since the socio-political crisis of 2010 and the politic of schooling children under 16 years, the perfect management of weeds in this culture has become a major problem. This study aims to assess the impact of chemical weeding on the socio-economic characteristics of the cassava producer in this country. The data collection was done in two stages. The first was to conduct a survey of cassava producers and the second, to conduct an experiment with an herbicide of the active ingredient â€œoxyfluorfenâ€ on a cassava variety called â€œBocou 1â€. The survey shows that the weed control technique affects weed management and the profile of the producers. The manual technique is the most practiced with over 85.44 p.c. The experiment showed also that chemical weeding associated to weeding with the machete is the most beneficial weed management method. The analysis of duration of weeding shows that a farmer takes an average of 28 days to weed a hectare with the daba against one day and half for chemical weeding Regarding the cost of weeding, the coupling of the chemical technique and the manual method is the least expensive.
Evaluation De Lâ€™effet De Lâ€™extrait Aqueux Des Feuilles De Abrus Precatorius (Fabaceae) Sur Le Poids Et La Prise Alimentaire Chez Des Rats
Authors: Lebri Marius , Lagou StÃ©phanie Marianne , Bahi Calixte , Zirihi GuÃ©dÃ© Noel , Coulibaly Adama , Chigr Fatia , Najimi Mohamed , Hafid Abderrafia , Khouili Mostafa 
Published: June 2020

Abrus precatorius est reconnue dans le monde pour ses nombreuses vertus thÃ©rapeutiques en mÃ©dicine traditionnelle. Des Ã©tudes ont montrÃ© que lâ€™extrait aqueux de ses feuilles est non toxique par voie orale chez des rats, ce qui pourrait justifier son innocuitÃ© observÃ©e chez lâ€™homme en mÃ©dicine traditionnelle. La prÃ©sente Ã©tude a pour objectif de rechercher lâ€™effet de lâ€™extrait aqueux des feuilles de A. precatorius sur le poids corporel et la prise alimentaire des rats traitÃ©s contre les tÃ©moins traitÃ©s Ã lâ€™eau distillÃ©e. Au cours de cette Ã©tude expÃ©rimentale de 21 jours, les animaux au nombre de 12 ont Ã©tÃ© rÃ©partis dans des cages individuelles puis regroupÃ©s en deux groupes de 6. Ils ont Ã©tÃ© gavÃ©s chaque jour Ã deux doses (2ml/100g) des substances dâ€™essai (matin/soir) pendant 7 jours et observÃ©s pendant 14 jours aprÃ¨s lâ€™arrÃªt du gavage. Afin de dÃ©terminer lâ€™influence de lâ€™extrait Ã la dose efficace (40 mg/ml) sur la croissance et la prise alimentaire des rats, lâ€™Ã©volution de ces deux paramÃ¨tres a Ã©tÃ© suivie pÃ©riodiquement tout au long de lâ€™expÃ©rimentation. Les resultats obtenues montrent que lâ€™extrait aqueux des feuilles de A. precatorius Ã la dose efficace (40 mg/ml) ne provoque pas de changement sur le poids et lâ€™alimentation des rats. Tous ces rÃ©sultats viennent justifier les nombreuses utilisations de la plante Abrus precatorius en mÃ©dicine traditionnelle.
Abrus precatorius is recognized worldwide for its many therapeutic virtues in traditional medicine. Studies have shown that the aqueous extract of its leaves is nontoxic orally in rats, which could justify its harmlessness observed in humans in traditional medicine. The purpose of this study is to investigate the effect of aqueous extract of A. precatorius leaves on body weight and feed intake of the treated rats against distilled water controls. During this 21-day experimental study, the 12 animals were distributed in individual cages and then grouped into two groups ofsix. They were force-fed every day with two doses (2ml / 100g) of the test substances. (Morning / evening) for 7 days and observe for 14 days after stopping force-feeding. In order to determine the influence of the extract at the effective dose (40 mg / ml) on the growth and feeding of the rats, the evolution of these two parameters was periodically monitored throughout the experiment. The results obtained show that the aqueous extract of A. precatorius leaves at the effective dose (40 mg / ml) does not cause any change in the weight and diet of the rats. All these results justify the many uses of the plant Abrus precatorius in traditional medicine.
CaractÃ©risation de la dÃ©formation des dÃ©pÃ´ts oligocÃ¨nes du Continental terminal 3 (Ct3) dans la rÃ©gion de Niamey (Bordure Orientale du Craton Ouest Africain, Bassin des Iullemmeden)
Authors: Ousmane Habsatou , Hantchi Karimou Dia , Hamidou Leyla Boubacar , Ali Ibrahim Abdou , KonatÃ© Moussa 
Published: June 2020

Cette Ã©tude porte sur la dÃ©termination des phases de dÃ©formations affectant les dÃ©pÃ´ts oligocÃ¨nes du Ct3, correspondant aux derniers dÃ©pÃ´ts de comblement du bassin des Iullemmeden dans la rÃ©gion de Niamey (Ouest, Niger). La mÃ©thodologie mise en Å“uvre est basÃ©e sur lâ€™analyse microtectonique de terrain soutenue par des donnÃ©es cartographiques et de lâ€™imagerie satellitaire. Les rÃ©sultats de cette Ã©tude montrent que les dÃ©pÃ´ts oligocÃ¨nes du Ct3 ont enregistrÃ© deux Ã©vÃ¨nements majeurs de lâ€™histoire tectonique de lâ€™Afrique de lâ€™Ouest au CÃ©nozoiÌˆque : la distension oligocÃ¨ne et la phase compressive post-oligocÃ¨ne, dâ€™Ã¢ge prÃ©sumÃ©e miocÃ¨ne. La phase distensive oligocÃ¨ne orientÃ©e ~N50Â° Ã ~N80Â° serait Ã©troitement contrÃ´lÃ©e par la dynamique mantellique prÃ©valant Ã cette Ã©poque, qui confÃ¨re une structuration en dÃ´mes et bassins Ã lâ€™Afrique de lâ€™Ouest. Ces mouvements mantelliques descendants, concomitant au dernier Ã©pisode de comblement du bassin des Iullemmeden, favoriseraient le rejeu en normal de la plupart des failles dâ€™orientation NW-SE. La phase compressive ~N140Â°, prÃ©sumÃ©e dâ€™Ã¢ge miocÃ¨ne, se serait produite dans un contexte rÃ©gional marquÃ© par la poursuitende la convergence Afrique-Europe. Au cours de cette phase compressive, les failles hÃ©ritÃ©es ont Ã©tÃ© rÃ©activÃ©es en dÃ©crochements soit senestres soit dextres en fonction de leur orientation par rapport Ã la direction de raccourcissement.
The aim of this study is about the determination deformations phases that affect the Ct3 Oligocene deposits in the Niamey area (West, Niger), which correspond to the last deposits of the Iullemmeden basin. The methodology implemented is based on the microtectonic field investigation supported by cartographic data and satellite imagery analysis. The results of this study show that the Oligocene deposits of Ct3 recorded two major events of the West Africa tectonic history during Cenozoic period: the first one was Oligocene distension and the second was a post-Oligocene compressive phase, presumed to be Miocene in age. The Oligocene distensive phase oriented ~N50Â° to ~N80Â° would be closely controlled by the mantle dynamics prevailing at that time, which gave domes and basins structuring in West Africa. These downward mantle movements, concomitantly with the last episode of the Iullemmeden basin infilling, would favor the normal reactivation of the most NW-SE trending faults. The ~N140Â° compressive phase, presumed to be Miocene in age, would have occurred in a regional shortening context, which was marked by the continuation of the Africa-Europe convergence. During this compressive phase, the inherited structures such as faults were reactivated in either senestral or dextral strike-slip faults according to their orientation with the shortening direction.