bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caregiver Well-Being and Burden: Variations by Race/Ethnicity and Care Recipient Nativity Status
Authors: Moon Heehyul E , Haley William E , Rote Sunshine M , Sears Jeanelle S 
Published: September 2020

AbstractBackground and ObjectivesDespite growing diversity among the aging population and extensive previous research on racial/ethnic minority caregivers, little research has been conducted on the potentially unique experiences and outcomes of informal caregivers of foreign-born care recipients. Using nationally representative data and the Stress Process Model, the current study examined the differences in caregiver outcomes (care burden, psychological well-being, and self-rated health) by care recipient nativity status (U.S.-born vs. foreign-born) and the extent to which caregiver outcomes vary by care recipient nativity status and caregiver race/ethnicity (non-Hispanic white, non-Hispanic black, Hispanic, and Others).Research Design and MethodsThe current study used Round 5 of the National Health and Aging Trends Study and the National Study of Caregiving (N = 1,436). We conducted ordinary least squares regression to analyze the differences in caregiver’s outcomes by care recipient nativity status and caregiver race/ethnicity and to investigate the impacts of the inclusion of caregiving factors (background factors, primary stressors, secondary stressors, and resources).ResultsRegression analyses showed that only care burden significantly varied by care recipient nativity status after controlling for covariates. Caregivers of foreign-born care recipients reported a higher burden. However, when interactions of care recipient nativity status × caregiver race/ethnicity were introduced, non-Hispanic black and Hispanic caregivers of foreign-born care recipients were more likely to report better psychological well-being and self-rated health compared to their counterparts. Across caregiver groups, better caregiver–care recipient relationship quality and less caregiver chronic conditions were associated with less burden and better caregiver psychological well-being and self-rated health.Discussion and ImplicationsCare recipient nativity status and caregiver race/ethnicity may have complex effects on caregiving experiences. Given the observed significant interaction effects for caregiver psychological well-being and self-rated health, cultural factors may affect the extent to which these caregivers appraise their caregiving. Future research should delve into the appropriate ways to assess care stress as well as resilience among each caregiver group. Our results indicate the need for research, education, and practice that assess cultural and within-group differences among caregivers and inform needed changes to structural barriers.
A demographic scaling model for estimating the total number of COVID-19 infections
Authors: Bohk-Ewald Christina , Dudel Christian , Myrskylä Mikko 
Published: September 2020

AbstractBackgroundUnderstanding how widely COVID-19 has spread is critical information for monitoring the pandemic. The actual number of infections potentially exceeds the number of confirmed cases.DevelopmentWe develop a demographic scaling model to estimate COVID-19 infections, based on minimal data requirements: COVID-19-related deaths, infection fatality rates (IFRs), and life tables. As many countries lack IFR estimates, we scale them from a reference country based on remaining lifetime to better match the context in a target population with respect to age structure, health conditions and medical services. We introduce formulas to account for bias in input data and provide a heuristic to assess whether local seroprevalence estimates are representative for the total population.ApplicationAcross 10 countries with most reported COVID-19 deaths as of 23 July 2020, the number of infections is estimated to be three [95% prediction interval: 2–8] times the number of confirmed cases. Cross-country variation is high. The estimated number of infections is 5.3 million for the USA, 1.8 million for the UK, 1.4 million for France, and 0.4 million for Peru, or more than one, six, seven and more than one times the number of confirmed cases, respectively. Our central prevalence estimates for entire countries are markedly lower than most others based on local seroprevalence studies.ConclusionsThe national infection estimates indicate that the pandemic is far more widespread than the numbers of confirmed cases suggest. Some local seroprevalence estimates largely deviate from their corresponding national mean and are unlikely to be representative for the total population.
Steady states of thin film droplets on chemically heterogeneous substrates
Authors: Liu Weifan , Witelski Thomas P 
Published: September 2020

Abstract
We study steady-state thin films on chemically heterogeneous substrates of finite size, subject to no-flux boundary conditions. Based on the structure of the bifurcation diagram, we classify the 1D steady-state solutions that exist on such substrates into six different branches and develop asymptotic estimates for the steady states on each branch. Using perturbation expansions, we show that leading-order solutions provide good predictions of the steady-state thin films on stepwise-patterned substrates. We show how the analysis in one dimension can be extended to axisymmetric solutions. We also examine the influence of the wettability contrast of the substrate pattern on the linear stability of droplets and the time evolution for dewetting on small domains. Results are also applied to describe 2D droplets on hydrophilic square patches and striped regions used in microfluidic applications.
Ceftolozane/tazobactam exposure in critically ill patients undergoing continuous renal replacement therapy: a PK/PD approach to tailor dosing
Authors: Gatti Milo , Giannella Maddalena , Raschi Emanuel , Viale Pierluigi , De Ponti Fabrizio 
Published: September 2020

Abstract

Objectives
To investigate the influence of continuous renal replacement therapy (CRRT) intensity on the clearance of ceftolozane/tazobactam in critical care patients, and to evaluate if the reported doses would achieve an optimal pharmacokinetic/pharmacodynamic (PK/PD) target against Pseudomonas aeruginosa exhibiting different MICs.

Methods
The MEDLINE–PubMed database was searched from inception to January 2020 to retrieve observational studies or case reports investigating the PK behaviour of ceftolozane/tazobactam during CRRT. Relevant CRRT settings and PK variables were extracted, and the influence of CRRT intensity on ceftolozane/tazobactam total clearance (CLtot) was determined by simple linear regression. The optimal PK/PD target for the reported doses was deemed to be achieved when ceftolozane trough concentrations (Cmin) were above the MIC (less intensive target) or four times the MIC (intensive target) for P. aeruginosa.

Results
Data from six studies including 11 patients (mean age 56.6 years) were analysed. Mean blood flow rate and effluent flow rate were 161.8 mL/min and 2383.4 mL/h, respectively. Ceftolozane Cmin ranged from 25.8 to 79.4 mg/L. A significant correlation was found for ceftolozane CLtot and effluent flow rate (P = 0.027). The intensive PK/PD target was achieved by 100% and 50% of the reported doses for MIC, respectively, up to 4 and 8 mg/L.

Conclusions
A significant correlation between effluent flow rate and ceftolozane clearance during CRRT could be identified. Higher dosing regimens coupled with continuous/extended infusion may be required in the case of higher CRRT intensity, deep-seated infections or poorly susceptible isolates. Larger studies assessing ceftolozane PK in different CRRT settings are warranted.
Patterns of frequent user interactions in blogosphere
Authors: Rudek Krzysztof , Koźlak Jarosław 
Published: September 2020

Abstract
The aim of the paper is to identify and categorize frequent patterns describing interactions between users in social networks. We analyze a social network with relationships between users that evolve in time already identified. In our research, we discover patterns based on frequent interactions between groups of users. The patterns are described by the characteristics of these interactions, such as their reciprocity, or the relative difference between estimations of global influences of the users participating in the discussions. The modification of the apriori algorithms is applied as one of the methods for pattern identification. The analyzed social network is built using the data set containing data from the Polish blog website salon24, which concerns mostly socio-political issues.
ddPCR Analysis Reveals BRAF V600E Mutations Are Infrequent in Isolated Pituitary Langerhans Cell Histiocytosis Patients
Authors: Nellan Anandani , Bodlak Avery , Mirsky David M , Mulcahy Levy Jean , Garrington Timothy P , Foreman Nicholas K , Gilani Ahmed , Hayashi Masanori 
Published: September 2020

Abstract
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with a highly variable clinical presentation affecting people of all ages. Mutations in BRAF V600E are the most identifiable molecular alteration in LCH although its incidence in pediatric patients with isolated pituitary stalk involvement is not well described. Pediatric patients with LCH and isolated pituitary stalk involvement typically present with central diabetes insipidus. Diagnosis requires a transcranial biopsy which often yields scant tissue. We sought to determine the prevalence of BRAF V600E mutations in patients with isolated pituitary stalk LCH using digital droplet polymerase chain reaction because this method requires minimal tumor DNA. We identified 8 patients with isolated pituitary stalk thickening who underwent a biopsy at Children’s Hospital Colorado from January 2001 to December 2019, as well as 6 patients with systemic LCH diagnosed by biopsy in the same period as a comparison. Only one out of the 8 patients with isolated thickened pituitary stalk was found to have a detectable BRAF V600E mutation. Five out of the 6 patients with systemic LCH had a detectable BRAF V600E mutation. In our series, BRAF V600E mutations are rare in pediatric patients with LCH and isolated pituitary stalk involvement.
Post-trauma transmesocolic hernia: a case report
Authors: Salam Doaa Hussin , Al-Tarakji Mohannad , Alaieb Abubaker Ibrahim , Singh Rajvir , El-Menyar Ayman , Al-Thani Hassan , Zarour Ahmad , Ellabib Mohamed 
Published: September 2020

Abstract
The prevalence of transmesocolic hernias, a subtype of internal hernias (IHs), is generally low. Its clinical consequences, including strangulation, ischemia and even death, however, necessitate awareness. IHs are classified as congenital or acquired as resulting from surgery, trauma or intraperitoneal inflammation. This is a case of a 37-year-old male victim of a motor vehicle collision 1 month prior to the index admission. The trauma-related injuries were managed conservatively and then discharged home. The patient was re-admitted with a 2-day history of epigastric pain, vomiting and abdominal distension. A diagnosis of small bowel obstruction due to a transmesocolic hernia was made on CT and emergency laparotomy performed. The post-operative course was unremarkable. It is vital to consider transmesocolic hernias in trauma patients presenting with a picture of bowel obstruction even in the absence of prior surgery.
Caecal volvulus in an incisional hernia
Authors: Ting Ying Yang , Farfus Anthony , Trochsler Markus 
Published: September 2020

Abstract
Caecal volvulus represents 25–40% of all colonic volvulus. Symptoms include abdominal distension, constipation, nausea and vomiting where it may be intermittent. Abdominal X-rays and computed tomography (CTs) may help with diagnosis and recommended treatment is resection of mobile caecum. A 70-year old comorbid woman with previous open bariatric surgery and known incisional hernia presented with symptoms of bowel obstruction. CT showed caecal volvulus contained within the ventral hernia confirmed intra-operatively. Patient recovered well and was discharged on Day 6 of admission. This is the second case described in literature of a caecal volvulus occurring in an incisional hernia. The altered normal anatomy may have contributed to caecal mobility. Diagnosis of caecal volvulus can be challenging, more so in the presence of a more clinically apparent pathology. We present a second known case of caecal volvulus in a giant incisional hernia, where there were unique challenges to management.
Trypanosoma cruziinfection in Latin American pregnant women living outside endemic countries and frequency of congenital transmission: a systematic review and meta-analysis
Authors: Colombo Valeria , Giacomelli Andrea , Casazza Giovanni , Galimberti Laura , Bonazzetti Cecilia , Sabaini Federico , Ridolfo Anna Lisa , Antinori Spinello 
Published: September 2020

AbstractBackgroundChagas disease, as a consequence of globalization and immigration, is no more restricted to Central and Latin America. Therefore, congenital transmission represents a growing public health concern in non-endemic countries.MethodsThe aim of this study was to assess the prevalence of Trypanosoma cruzi infection in pregnant Latin American (LA) women living outside endemic countries and the rate of congenital transmission. Data were extracted from studies indexed in PubMed, Scopus, Embase, Lilacs and SciELO databases without language restriction. Two investigators independently collected data on study characteristics, diagnosis, prevalence of infection in pregnant women and congenital infection rate. The data were pooled using a random effects model.ResultsThe search identified 1078 articles of which 29 were eligible regarding prevalence of T. cruzi infection among pregnant women and 1795 articles of which 32 were eligible regarding the congenital transmission rate. The estimated pooled prevalence of T. cruzi infection in LA pregnant women was 4.2% [95% confidence interval (CI): 3.0–5.5]. The prevalence of T. cruzi infection in pregnant women from Bolivia was 15.5% (95% CI: 11.7–19.7) and 0.5% (95% CI: 0.2–0.89) for those coming from all other LA countries. The estimated global rate of congenital transmission was 3.5% (95% CI: 2.5–4.5); excluding poor-quality studies, the rate of congenital transmission was 3.8% (95% CI: 2.4–5.1).ConclusionsPrevalence of Chagas disease among LA pregnant women living outside endemic countries is high, particularly in Bolivian women. The rate of vertical transmission of T. cruzi infection is similar to the rate reported in South and Central American countries.
Different Sources of Allelic Variation Drove Repeated Color Pattern Divergence in Cichlid Fishes
Authors: Urban Sabine , Nater Alexander , Meyer Axel , Kratochwil Claudius F 
Published: September 2020

AbstractThe adaptive radiations of East African cichlid fish in the Great Lakes Victoria, Malawi, and Tanganyika are well known for their diversity and repeatedly evolved phenotypes. Convergent evolution of melanic horizontal stripes has been linked to a single locus harboring the gene agouti-related peptide 2 (agrp2). However, where and when the causal variants underlying this trait evolved and how they drove phenotypic divergence remained unknown. To test the alternative hypotheses of standing genetic variation versus de novo mutations (independently originating in each radiation), we searched for shared signals of genomic divergence at the agrp2 locus. Although we discovered similar signatures of differentiation at the locus level, the haplotypes associated with stripe patterns are surprisingly different. In Lake Malawi, the highest associated alleles are located within and close to the 5′ untranslated region of agrp2 and likely evolved through recent de novo mutations. In the younger Lake Victoria radiation, stripes are associated with two intronic regions overlapping with a previously reported cis-regulatory interval. The origin of these segregating haplotypes predates the Lake Victoria radiation because they are also found in more basal riverine and Lake Kivu species. This suggests that both segregating haplotypes were present as standing genetic variation at the onset of the Lake Victoria adaptive radiation with its more than 500 species and drove phenotypic divergence within the species flock. Therefore, both new (Lake Malawi) and ancient (Lake Victoria) allelic variation at the same locus fueled rapid and convergent phenotypic evolution.
Evolution of a highly functional circular DNA aptamer in serum
Authors: Mao Yu , Gu Jimmy , Chang Dingran , Wang Lei , Yao Lili , Ma Qihui , Luo Zhaofeng , Qu Hao , Li Yingfu , Zheng Lei 
Published: September 2020

AbstractCircular DNA aptamers are powerful candidates for therapeutic applications given their dramatically enhanced biostability. Herein we report the first effort to evolve circular DNA aptamers that bind a human protein directly in serum, a complex biofluid. Targeting human thrombin, this strategy has led to the discovery of a circular aptamer, named CTBA4T-B1, that exhibits very high binding affinity (with a dissociation constant of 19 pM), excellent anticoagulation activity (with the half maximal inhibitory concentration of 90 pM) and high stability (with a half-life of 8 h) in human serum, highlighting the advantage of performing aptamer selection directly in the environment where the application is intended. CTBA4T-B1 is predicted to adopt a unique structural fold with a central two-tiered guanine quadruplex capped by two long stem–loops. This structural arrangement differs from all known thrombin binding linear DNA aptamers, demonstrating the added advantage of evolving aptamers from circular DNA libraries. The method described here permits the derivation of circular DNA aptamers directly in biological fluids and could potentially be adapted to generate other types of aptamers for therapeutic applications.
Outpatient Parenteral Antimicrobial Therapy With Ceftolozane/Tazobactam via Continuous Infusion for Multidrug-Resistant Pseudomonas aeruginosa Osteomyelitis
Authors: Álvarez Otero Judith , Lamas Ferreiro Jose Luis , Sanjurjo Rivo Ana , de la Fuente Aguado Javier 
Published: September 2020

Abstract
We present a case of Pseudomonas aeruginosa osteomyelitis treated with surgery and antibiotic therapy with ceftolozane-tazobactam in continuous infusion at home using an elastomeric pump. We discuss the use of ceftolozane-tazobactam in continuous infusion administered at home as an effective alternative for the treatment of multidrug-resistant Pseudomonas aeruginosa osteomyelitis.
A Retrospective Cohort Study of Urgent Care Visits and Revisits for Headache/Migraine
Authors: Minen Mia , Zhou Kina , Lall Ramona , Friedman Benjamin W 
Published: September 2020

Abstract
Objective. Increasingly, patients are seeking same-day care at urgent care (UC) facilities. Little is known about the health care utilization patterns of patients who visit UC facilities for headache and migraine. We examined the frequency of headache and migraine visits and revisits at UC facilities. Methods. We conducted a retrospective cohort study of headache not otherwise specified (NOS) and migraine visits from 67 NYC UC facilities over an eight-month period. We report descriptive analyses, the frequency of headache NOS revisits, and the elapsed time to revisits. Results. There were 10,240 patients who visited UC facilities for headache NOS or migraine within the eight-month period. The majority of patients, 6,994 (68.3%), were female, and the mean age (SD) was 35.1 (15.0) years. Most (93.9%) patients (N = 9,613) lived within 60 miles of NYC; 5.5% (N = 564) had at least one revisit, and among re-visitors, there was an average (SD) of 2.2 (0.7) visits to UC facilities during the study period and an average time to revisit (SD) of 61.3 (55.2) days. Conclusions. In just eight months, there were &gt;10,000 headache NOS and migraine visits to UC facilities in NYC, with half of revisits occurring within 90 days. Future work should examine headache management in UC facilities.
Development of a dual-phase xenon TPC with a quartz chamber for direct dark matter searches
Authors: Sato Kazufumi , Yamashita Masaki , Ichimura Koichi , Itow Yoshitaka , Kazama Shingo , Moriyama Shigetaka , Ozaki Kosuke , Suzuki Takumi , Yamazaki Rina 
Published: September 2020

Abstract
The idea of a hermetic quartz chamber in a dual-phase xenon time projection chamber (TPC) has the potential to improve the detector sensitivity for direct dark matter searches in the future. A major challenge facing TPC detectors in future dark matter experiments will be the reduction of the internal background such as $^{222}$Rn and the deterioration of the ionization signal due to electronegative impurities. The hermetic quartz chamber can isolate the TPC’s sensitive volume from external interference and is thus expected to prevent contamination caused by radioactive and electronegative impurities, which originate from the outer detector materials. At the Kamioka Observatory in Japan, we have developed a TPC with a quartz chamber that contains a ⌀$ 48 \times 58$ mm volume of liquid xenon. At this development stage, we have not aimed for perfect hermeticity of the quartz chamber. Our aim here is twofold: first, to demonstrate via the use of a calibration source that the presence of quartz materials in the TPC does not impact its operation; and second, to perform quantitative measurements of the TPC’s characteristics. We successfully measured electron drift velocities of 1.2–1.7 mm/$\mu$s in liquid xenon under electric fields ranging from 75–384 V/cm, and also observed small S2 signals produced by a single ionized electron with a light yield of 16.5 $\pm$ 0.5 PE. These results were consistent with the expected values; therefore, our demonstrations provide a proof of principle for TPCs incorporating a quartz chamber.