bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective evaluation of the Dutch pre‐newborn screening cohort for propionic acidemia and isolated methylmalonic acidemia: What to aim, expect, and evaluate from newborn screening?
Authors: Haijes Hanneke A. , Molema Femke , Langeveld Mirjam , Janssen Mirian C. , Bosch Annet M. , van Spronsen Francjan , Mulder Margot F. , Verhoeven‐Duif Nanda M. , Jans Judith J.M. , van der Ploeg Ans T. , Wagenmakers Margreet A. , Rubio‐Gozalbo M. Estela , Brouwers Martijn C. G. J. , de Vries Maaike C. , Langendonk Janneke G. , Williams Monique , van Hasselt Peter M. 
Published: December 2019

AbstractEvidence for effectiveness of newborn screening (NBS) for propionic acidemia (PA) and isolated methylmalonic acidemia (MMA) is scarce. Prior to implementation in the Netherlands, we aim to estimate the expected health gain of NBS for PA and MMA. In this national retrospective cohort study, the clinical course of 76/83 Dutch PA and MMA patients, diagnosed between January 1979 and July 2019, was evaluated. Five clinical outcome parameters were defined: adverse outcome of the first symptomatic phase, frequency of acute metabolic decompensations (AMD), cognitive function, mitochondrial complications, and treatment‐related complications. Outcomes of patients identified by family testing were compared with the outcomes of their index siblings. An adverse outcome due to the first symptomatic phase was recorded in 46% of the clinically diagnosed patients. Outcome of the first symptomatic phase was similar in 5/9 sibling pairs and better in 4/9 pairs. Based on the day of diagnosis of the clinically diagnosed patients and sibling pair analysis, a preliminary estimated reduction of adverse outcome due to the first symptomatic phase from 46% to 36%‐38% was calculated. Among the sibling pairs, AMD frequency, cognitive function, mitochondrial, and treatment‐related complications were comparable. These results suggest that the health gain of NBS for PA and MMA in overall outcome may be limited, as only a modest decrease of adverse outcomes due to the first symptomatic phase is expected. With current clinical practice, no reduced AMD frequency, improved cognitive function, or reduced frequency of mitochondrial or treatment‐related complications can be expected.
A preliminary survey of Zika virus infection by nucleic acid test in the volunteer blood donor samples in Shenzhen China
Authors: Zheng Xin , Zeng Jingfeng , Xu Xiaoxuan , Liu Yizhong , Heng Liu , Wen Xiong , Li Shilin , Xu Min , Wu Shaobo , Chen Yongjun , Chen Limin 
Published: December 2019

AbstractAlthough Zika virus (ZIKV) infection is mainly transmitted through mosquito bite, it can also be transmitted through blood transfusion. More than 500 000 cases of ZIKV infection were reported in the Americas from 2015 to 2016. Up till now, over 10 cases of imported ZIKV infection have been reported due to frequent international exchanges in the Shenzhen city of Guangdong Province, China. Unfortunately, there were no data on ZIKV infection in Chinese blood donors because it has not been included in routine screening for volunteer blood donors. As such, we performed a preliminary survey of the prevalence of ZIKV infection among volunteer blood donors in Shenzhen, China, to assess the potential risk of ZIKV infection through transfusion. A total of 9626 blood donor samples were collected and ZIKA RNA was detected by transcription‐mediated amplification (TMA) nucleic acid amplification method with the Panther nucleic acid automatic analysis system of Grifols, Spain, including Procleix ZIKV Assay reagent. All the experiments in this study were conducted in accordance with the standard operating procedure of the blood center. Of the 9626 donor blood samples tested, none of these samples was Zika RNA reactive. There was no positive case from ZIKV RNA screening in this preliminary survey. There was no ZIKV presence in blood donors in Shenzhen, China, from this preliminary survey. The potential risk of ZIKV infection by transfusion is low in Shenzhen at this moment. Therefore, there is no need to add ZIKV nucleic acid test as a routine screening for blood donors.
Strain engineering of the lattice vibration modes in monolayer black phosphorus
Authors: Zhang Liang , Li Hai , Sun Changqing , Ouyang Gang 
Published: December 2019

AbstractStrain engineering can be served as an efficient tool for tuning physical properties of two‐dimentional (2D) materials. However, the quantifying strain and characterizing its spatially inhomogeneous distribution are always challenging. Here, we report the strain‐induced lattice vibration mode variations in monolayer black phosphorus (BP) and clarify the underlying mechanism resorting to the bond relaxation theory based on the combination of mass‐spring model and Lagrangian dynamics. We reveal that the
and B2g modes exhibit blue (red) shifts while the
mode shows a red (blue) shift through applying an armchair (zigzag) strain, which can be ascribed to the orientation‐dependent lattice vibration mode variations resulting from the different responses of force constants. Moreover, it is found that a negative Poisson's ratio along the out‐of‐plane direction emerges when the strain is applied in the zigzag direction. Our results offer intriguing insights into the underlying physics of vibration mode variations in strained BP‐like 2D layered materials.
Direct repair of iatrogenic thoracic duct injury through lymphovenous anastomosis (LVA): A case report
Authors: Rodi Timo , Tung Nguyen Ba , Fritsche Elmar , Rajan Gunesh , Scaglioni Mario F. 
Published: December 2019

AbstractThis is a case report of a 64‐year‐old male with cancer with an unknown primary and bilateral cervical lymph node metastases. Twelve months after chemo‐, radio‐, immunotherapy, and radical neck dissection, he presented with recurrent cervical metastases. The patient underwent radical revision neck dissection including the deep neck muscles of the cervical plexus and reconstruction with a free anterolateral thigh flap. During tumor resection, parts of the thoracic duct were removed which resulted in a large lymph leak. This was addressed by creating a lymphovenous anastomosis to a branch of the subclavian vein. The flow of lymph was reinstated, and no leak has been observed up to a recent 6‐month follow‐up.
Using Distance Sampling‐Based Integrated Population Models to Identify Key Demographic Parameters
Authors: Schmidt Joshua H. , Robison Hillary L. 
Published: December 2019

ABSTRACTEffective wildlife management relies on rigorous estimates of population parameters, although data for small populations are often sparse, limiting inference. Integrated population models (IPMs) offer a potential solution by formally combining data sets in a unified analysis, thereby improving precision and allowing the estimation of latent parameters. We expected that incorporating open‐population distance sampling models into an IPM framework would provide further advantages for assessing population dynamics, particularly for rare species. We present an open‐distance IPM combining separate sources of abundance, composition, survival, and harvest data to better understand the dynamics of a small (~200 individuals) muskox (Ovibos moschatus) population in northwestern Alaska, USA. There was a 75% chance the muskox population in our study area was declining (λ < 1.0), primarily because of a −4.3%/year decline in adult females, and estimated survival probabilities were 0.70, 0.87, and 0.89 for yearlings, adult females, and adult males (harvest excluded), respectively. Insufficient numbers of recruits drove the decline in adult females, and harvest likely limited the adult male component of the population, accounting for up to 50% of mortalities. Together, these results suggest more conservative harvest management might be appropriate moving forward. In contrast, the results from a more conventional analysis were largely ambiguous, which would inevitably lead to delays in the application of appropriate management actions. Our work furthers the development of open‐population distance sampling models and IPMs and demonstrates an efficient approach for managing small populations when extensive marking of individuals is not possible. Published 2019. This article is a U.S. Government work and is in the public domain in the USA.
Photo‐Crosslinking Strategy Constructs Adhesive, Superabsorbent, and Tough PVA‐Based Hydrogel through Controlling the Balance of Cohesion and Adhesion
Authors: Li Zhangkang , Wang Dawei , Bai Huiyu , Zhang Shengwen , Ma Piming , Dong Weifu 
Published: December 2019

AbstractAn ideal hydrogel with excellent adhesive performance has drawn much attention in research and applications. In this paper, a photo‐crosslinked polyvinyl alcohol bearing styrylpyridinium group/cellulose nanocrystals (PVA‐SbQ/CNC) composite hydrogel is designed through photo‐crosslinking technology for preventing the physical crosslinking of polyvinyl alcohol to maintain enough hydroxy groups in the hydrogel. Thus, the hydrogel exhibits excellent adhesive behavior not only for various solid substrates (plastics, rubbers, glasses, metals, and woods) but also muscle and fat. In addition, the formation mechanism, the swelling behavior, and mechanical strength are also investigated. Also, these results show that photo‐crosslinked PVA‐SbQ/CNC hydrogel possesses high swelling rate, super stretchability, and high toughness. Moreover, adhesive, mechanical, and swelling properties of PVA‐SbQ/CNC hydrogels can be changed with the increase of total incident light intensity. It is anticipated that the photo‐crosslinked PVA‐SbQ/CNC hydrogel would play a significant role in the applications of wound dressing, medical electrodes, tissue adhesives, portable equipment, and super absorbent materials. In this sense, the simple photo‐crosslinking strategy would provide new ideas for designing soft and adhesive materials through controlling the balance of cohesion and adhesion.
UWB bandpass filter with compact size and wide upper stopband
Authors: Zeng Junjie , Li Xiuping , Qi Zihang 
Published: December 2019

AbstractA novel ultra‐wideband (UWB) bandpass filter (BPF) with a very compact size and improved out‐of‐band performance is proposed in this letter. The main circuit structure is a composite right‐/left‐handed transmission line unit cell, which has UWB bandpass characteristic as well as compact size. Moreover, two anticoupled line structures added at both ends of the unit cell can produce a new resonant mode and three transmission zeros, so the passband response and upper stopband performance can be improved. The proposed filter is implemented and measured, which shows its 3 dB passband ranges from 3.3 to 10.9 GHz with a fractional bandwidth of 110.9%. Its insertion loss is about 0.6 dB at the centre frequency, while the return loss is better than 13 dB. In addition, the measured results also show the proposed filter has a wide stopband from 11.4 to 30 GHz, whose rejection level is greater than 18 dB. The size of the filter is only 7.4 × 6.4 mm, equal to 0.22 × 0.20 λg. Both the simulated and measured results are in good agreement.
Peptidomic analysis of blastocyst culture medium and the effect of peptide derived from blastocyst culture medium on blastocyst formation and viability
Authors: Ji Hui , Shi Xiaodan , Wang Jiayi , Cao Shanren , Ling Xiufeng , Zhang Junqiang , Shen Rong , Zhao Chun 
Published: December 2019

AbstractHigh‐quality in vitro human embryo culture medium can improve the blastocyst formation rate and blastocyst quality and be beneficial for the clinical application of single blastocyst transfer. Mammalian embryos can secrete protein products into the surrounding medium. As a group of bioactive molecules and degraded proteins, peptides have been shown to participate in various biological processes. Using liquid chromatography‐tandem mass spectrometry, we performed comparative peptidomic analysis of human culture medium in blastocyst formation and nonblastocyst‐formation groups. A total of 201 differentially expressed peptides originating from 157 precursor proteins were identified. Among these, a peptide derived from HERC2 (peptide derived from blastocyst culture medium [PDBCM]) passed through the zona pellucida, was distributed on the perivitelline space, was absent in arrest embryos and highly expressed in high‐quality blastocysts compared with low‐quality blastocysts, and significantly promoted blastocyst formation in a concentration‐dependent manner. These results indicate that PDBCM may be a novel biomarker for predicting blastocyst formation and viability. The mechanism remains unclear and needs to be explored in the future.
p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies
Authors: Singh Naveena , Piskorz Anna M , Bosse Tjalling , Jimenez‐Linan Mercedes , Rous Brian , Brenton James D , Gilks C Blake , Köbel Martin 
Published: December 2019

AbstractTP53 mutations are considered a surrogate biomarker of the serous‐like ‘copy number high’ molecular subtype of endometrial carcinoma (EC). In ovarian carcinoma, p53 immunohistochemistry (IHC) accurately reflects mutational status with almost 100% specificity but its performance in EC has not been established. This study tested whether p53 IHC reliably predicts TP53 mutations identified by next‐generation sequencing (NGS) in EC biopsy samples for all ECs and as part of a molecular classification algorithm after exclusion of cases harbouring mismatch repair defects (MMRd) or pathogenic DNA polymerase epsilon exonuclease domain mutations (POLEmut). A secondary aim assessed inter‐laboratory variability in p53 IHC. From a total of 207 cases from five centres (37–49 cases per centre), p53 IHC carried out at a central reference laboratory was compared with local IHC (n = 164) and curated tagged‐amplicon NGS TP53 sequencing results (n = 177). Following consensus review, local and central p53 IHC results were concordant in 156/164 (95.1%) tumours. Discordant results were attributable to both interpretive and technical differences in staining between the local and central laboratories. When results were considered as any mutant pattern versus wild‐type pattern staining, however, there was disagreement between local and central review in only one case. The concordance between p53 IHC and TP53 mutation was 155/168 (92.3%) overall, and 117/123 (95.1%) after excluding MMRd and POLEmut EC. Three (3/6) discordant results were in serous carcinomas with complete absence of p53 staining but no detectable TP53 mutation. Subclonal mutant p53 IHC expression was observed in 9/177 (5.1%) cases, of which four were either MMRd or POLEmut. Mutant pattern p53 IHC was observed in 63/63 (100%) serous carcinomas that were MMR‐proficient/POLE exonuclease domain wild‐type. Optimised p53 IHC performs well as a surrogate test for TP53 mutation in EC biopsies, demonstrates excellent inter‐laboratory reproducibility, and has high clinical utility for molecular classification algorithms in EC. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
On the ensemble‐based linearization of numerical models
Authors: Yaremchuk Max , Nechaev Dmitri , Frolov Sergey 
Published: December 2019

AbstractCurrent parallelization trends in computer technology facilitates development of the algorithms that retrieve linear approximations of the model operators and their adjoints from ensembles of model simulations. In this study we address the problem of obtaining exact linearizations in the presence of semi‐implicit numerics of the parent model under realistic constraints on the ensemble size. The method is based on factorization of the model into a sequence of local and non‐local linear operators and employs prior information on the structure of the respective sparse matrices. The performance of the method is tested using 28 perturbed solutions of the shallow‐water equations with a moderate size () state vector. Numerical experiments have shown feasibility of the approach under relatively general constraints on the structure of the parent model. Because of the substantial expense of the ensemble‐based linearization, special focus is made on the assessment of the optimal frequency of such computations within the time intervals between data injections in typical operational systems.
An interval observer for uncertain continuous‐time linear systems
Authors: Meslem Nacim , Martinez John , Ramdani Nacim , Besançon Gildas 
Published: December 2019

SummaryTo design robust interval observers for uncertain continuous‐time linear systems, a new set‐integration approach is proposed to compute trajectory tubes for the estimation error. Because this approach, the order‐preserving condition on the dynamics of the estimation error is no longer required. Therefore,
synthesis methods can be used to compute observer gains that reduce the impact of the system uncertainties on the accuracy of the estimated state enclosures. The performance of the proposed approach is showcased through illustrative numerical examples.
Moving toward sustainable development: The relationship between water productivity, natural resource rent, international trade, and carbon dioxide emissions
Authors: Danish  
Published: December 2019

AbstractThis empirical work examines the relationships among energy consumption, real income, and carbon emissions considering the role of water productivity, natural resource rent, and international trade in the global economy from 1990 to 2013. Bayer–Hanck's combined cointegration test confirms the cointegration among variables under consideration in this study. The study also uses auto‐regressive distributive lag approach for long‐term and short‐term estimation. Empirical findings summarize that water productivity, natural resources, and international trade increase carbon emissions level. Two‐way causality is found between water productivity and carbon emissions and between energy consumption and water productivity. These results show that more efficient use of energy and water resources would be an effective strategy to combat global warming.
Understanding the In Situ Mechanistic Control of Plant‐Derived Carbon Quantum Dots on the Synthesis of Gold Nanoparticles
Authors: Shukla Devyani , Bose Subhaya , Choudhury Smarajit P. , K. Sharma Vinay , Das Megha , Sabbarwal Shivesh , Yadav Sanjeev K. , Kumar Manoj , Parmar Avanish S. 
Published: December 2019

AbstractArjuna terminalia‐ derived Carbon Quantum Dots synthesized by hydrothermal method are utilized to investigate the effect of their reaction parameters on the synthesis and growth of gold nanoparticles. In this study, carbon dots are synthesized at two temperatures (160 °C and 200 °C) and two solvents (water and ethanol) to investigate the effect of four variants on the formation of non‐cytotoxic gold nanoparticles. They are extensively characterized to understand their different physical and chemical properties. Gold nanoparticles synthesized using ethanol based carbon dots show greater stability. Addition of Type‐I collagen stabilizes the gold nanoparticles to form gold nanoparticle‐coated collagen fibrils. Further, β‐mercaptoethanol initiates a spontaneous precipitation and sedimentation of visible gold micelles similar to “snowing”. This work may help in future to understand the reduction of chloroauric acid using bio‐derived plant extracts, microbial consortium and very recently, carbon quantum dots, for specific tailoring of gold nanoparticles for biomedical, surface‐enhanced Raman spectroscopy and theranostics applications.
Improved Removal of Cr(VI) using Fe3O4/C Magnetic Nanocomposites Derived from Potassium Fulvic Acid
Authors: Su Qiaohong , Lin Zhang , Tian Chen , Su Xintai , Xue Xiaogang , Su Zhi 
Published: December 2019

AbstractThe development of high performance magnetic nanomaterials has a good application prospect in wastewater treatment. Herein, Fe3O4/C nanocomposites was synthesized by eco‐friendly hydrolysis‐calcination method using potassium fulvic acid (FA−K) and FeCl3⋅6H2O as raw materials. The morphology of Fe3O4/C nanocomposites exhibited a loose pore structure with uniform size (a diameter ∼ 27 nm). The prepared Fe3O4/C nanocomposites possessed excellent dispersibility and magnetic properties in aqueous solution. The removal efficiency and maximum adsorption capacity of Fe3O4/C nanocomposites were 98% and 64.0 mg g−1, respectively. Moreover, it was confirmed that the adsorption mechanism of Cr(VI) contains electrostatic attraction and redox reaction. In this work, we provide a convenient means for manufacturing Fe3O4/C nanocomposites, and prove that FA−K is a cheap carbon source for manufacturing Fe3O4/C nanocomposites, which makes Fe3O4/C nanocomposites have potential application value in the effective adsorption of Cr(VI).
Theory of cell fate
Authors: Casey Michael J. , Stumpf Patrick S. , MacArthur Ben D. 
Published: December 2019

AbstractCell fate decisions are controlled by complex intracellular molecular regulatory networks. Studies increasingly reveal the scale of this complexity: not only do cell fate regulatory networks contain numerous positive and negative feedback loops, they also involve a range of different kinds of nonlinear protein–protein and protein–DNA interactions. This inherent complexity and nonlinearity makes cell fate decisions hard to understand using experiment and intuition alone. In this primer, we will outline how tools from mathematics can be used to understand cell fate dynamics. We will briefly introduce some notions from dynamical systems theory, and discuss how they offer a framework within which to build a rigorous understanding of what we mean by a cell “fate”, and how cells change fate. We will also outline how modern experiments, particularly high‐throughput single‐cell experiments, are enabling us to test and explore the limits of these ideas, and build a better understanding of cellular identities.This article is categorized under:
Models of Systems Properties and Processes > Mechanistic Models
Biological Mechanisms > Cell Fates
Models of Systems Properties and Processes > Cellular Models
Methodologic Requirements for Assessing Surgical Procedures in Current Medical Literature
Authors: Jiménez Rosa E. , Gutiérrez Angela R. , Benitez Iralys M. 
Published: December 2019

AbstractEven though, in theory, a new surgical technique should traverse all the stages established for drugs before being introduced into medical practice, it is suspected that many surgical procedures are utilized without having rigorously evaluated their efficacy and safety. With the aim of identifying the methodologic aspects currently employed for assessing new surgical procedures, a descriptive bibliographic study was carried out. Altogether, 75 journal articles published from 1996 to 1998 were reviewed. The papers must have come from studies carried out with the expressed objective of evaluating a surgical procedure and were selected through MEDLINE or directly from six prestigious medical journals (three specifically surgical and three general). Of the reviewed articles, 47% were retrospective studies, and the rest were prospective studies. More than 40% of the retrospective studies omitted some basic methodologic features, namely a description of the patients’ source or a definition of the inclusion criteria. Among the 41 prospective articles, only 35 used a control group and 15 did not employ random allocation. Other basic issues, such as the sample size or inclusion of prognostic factors in the analysis, were present in fewer than 50% of the articles. It seems there is consensus about admitting that rigorous assessment of new surgical treatments should be an unavoidable condition before introducing such treatment into practice. The facts demonstrate that this principle is not being followed.