bluuebunny/crossref_metadata_2025_split huggingface dataset:
Who cannot work from home? Characterizing occupations facing increased risk during the COVID-19 pandemic using 2018 BLS data
Authors: Baker Marissa G. 
Published: March 2020

AbstractObjectivesNot all workers are employed in occupations in which working from home is possible. These workers are at an increased risk for exposure to infectious disease during a pandemic event, and are more likely to experience events of job displacement and disruption during all types of public health emergencies. Here, I characterized which occupational sectors in the United States are most able to work from home during a public health emergency such as COVID-19.Methods2018 national employment and wage data maintained by the U.S. Bureau of Labor Statistics (BLS) was merged with measures from the BLS O*NET survey data. The measures utilized rank the importance of using a computer at work, and the importance of working with or performing for the public, which relate to the ability to complete work at home.ResultsAbout 25% (35.6 M) of the U.S. workforce are employed in occupations which could be done from home, primarily in sectors such as technology, computer, management, administrative, financial, and engineering. The remaining 75% of U.S. workers (including healthcare, manufacturing, retail and food services, et al.) are employed in occupations where working from home would be difficult.ConclusionsThe majority of U.S. workers are employed in occupations that cannot be done at home, putting 108.4 M U.S. workers at increased risk for adverse health outcomes related to working during a public health emergency. These workers tend to be lower paid than workers who can work from home. During COVID-19, this could result in a large increase in the burden of mental health disorders in the U.S., in addition to increased cases of COVID-19 due to workplace transmission. Public health guidance to “work from home” is not applicable to the majority of the U.S. workforce, emphasizing the need for additional guidance for workers during public health emergencies.
Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial
Authors: Bian Huijie , Zheng Zhao-Hui , Wei Ding , Zhang Zheng , Kang Wen-Zhen , Hao Chun-Qiu , Dong Ke , Kang Wen , Xia Jie-Lai , Miao Jin-Lin , Xie Rong-Hua , Wang Bin , Sun Xiu-Xuan , Yang Xiang-Min , Lin Peng , Geng Jie-Jie , Wang Ke , Cui Hong-Yong , Zhang Kui , Chen Xiao-Chun , Tang Hao , Du Hong , Yao Na , Liu Shuang-Shuang , Liu Lin-Na , Zhang Zhe , Gao Zhao-Wei , Nan Gang , Wang Qing-Yi , Lian Jian-Qi , Chen Zhi-Nan , Zhu Ping 
Published: March 2020

SummaryBackgroundSARS-CoV-2 is a novel human coronavirus, there is no specific antiviral drugs. It has been proved that host-cell-expressed CD147 could bind spike protein of SARS-CoV-2 and involve in host cell invasion. Antibody against CD147 could block the infection of SARS-CoV-2. We aimed to assess the efficacy and safety of meplazumab, a humanized anti-CD147 antibody, as add-on therapy in patients with COVID-19 pneumonia.MethodsAll patients received recommended strategy fromChinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatmentsreleased by National Health Commission of China. Eligible patients were add-on administered 10 mg meplazumab intravenously at days 1, 2, and 5. Patients hospitalized in the same period were observed as concurrent control. The endpoints include virological clearance rate, case severity, chest radiographic, and laboratory test. This trial was approved by the Ethics Committee of Institution at the Tangdu hospital, and registered with ClinicalTrials.gov, NCT 04275245.Findings17 patients were enrolled and assigned to meplazumab group between Feb 3, 2020 and Feb 10, 2020. 11 hospitalized patients served as concurrent control. Baseline characteristics were generally balanced across two groups. Compared to control group, meplazumab treatment significantly improved the discharged (p=0.005) and case severity (p=0.021) in patients. The time to virus negative in meplazumab group was reduced than that in control group (median 3, 95%CI[1.5-4.5] vs. 13, [6.5-19.5]; p=0.045, HR=0.374, 95%CI[0.143-0.978]). The percentages of patients recovered to the normal lymphocyte count and CRP concentration were also increased remarkably and rapidly in meplazumab group. No adverse effect was found in meplazumab-treated patients.InterpretationMeplazumab efficiently improved the recovery of patients with SARS-CoV-2 pneumonia with a favorable safety profile. Our results support to carry out a large-scale investigation of meplazumab as a treatment for COVID-19 pneumonia.FundingNational Science and Technology Major Project.
CRISPR/Cpf1 mediated genome editing enhancesBombyx moriresistance to BmNPV
Authors: Dong Zhanqi , Qin Qi , Hu Zhigang , Zhang Xinling , Miao Jianghao , Huang Liang , Chen Peng , Lu Cheng , Pan Minhui 
Published: March 2020

AbstractCRISPR/Cas12a (Cpf1) is a single RNA-guided endonuclease that provides new opportunities for targeted genome engineering through the CRISPR/Cas9 system. Only AsCpf1 have been developed for insect genome editing, and the novel Cas12a orthologs nucleases and editing efficiency require more study in insect. We compared three Cas12a orthologs nucleases, AsCpf1, FnCpf1, and LbCpf1, for their editing efficiencies and antiviral abilitiesin vitro. The three Cpf1 efficiently edited the BmNPV genome and inhibited BmNPV replication in BmN-SWU1 cells. The antiviral ability of the FnCpf1 system was more efficient than the SpCas9 system after infection by BmNPV. We created FnCpf1×gIE1 and SpCas9×sgIE1 transgenic hybrid lines and evaluated the gene editing efficiency of different systems at the same target site. We improved the antiviral ability using the FnCpf1 system in transgenic silkworm. This study demonstrated use of the CRISPR/Cpf1 system to achieve high editing efficiencies in the silkworm, and illustrates the use of this technology for increasing disease resistance.Author SummaryGenome editing is a powerful tool that has been widely used in gene function, gene therapy, pest control, and disease-resistant engineering in most parts of pathogens research. Since the establishment of CRISPR/Cas9, powerful strategies for antiviral therapy of transgenic silkworm have emerged. Nevertheless, there is still room to expand the scope of genome editing tool for further application to improve antiviral research. Here, we demonstrate that three Cpf1 endonuclease can be used efficiency editing BmNPV genomein vitroandin vivofor the first time. More importantly, this Cpf1 system could improve the resistance of transgenic silkworms to BmNPV compare with Cas9 system, and no significant cocoons difference was observed between transgenic lines infected with BmNPV and control. These broaden the range of application of CRISPR for novel genome editing methods in silkworm and also enable sheds light on antiviral therapy.
Pre-school teachers’ perceptions of challenging behaviours of students with autism spectrum disorder within inclusive settings
Authors: Nah Yong-Hwee 
Published: March 2020

Purpose
Students with autism spectrum disorder (ASD) often have challenging behaviours that can create significant teaching challenges in group settings such as in mainstream pre-school inclusive settings. This study aims to identify and understand, from the perspectives of mainstream pre-school teachers in Singapore, the type of common challenging behaviours observed in pre-schoolers (mean age = 4.5 years, SD = 1.1, range = 3-6) with ASD.

Design/methodology/approach
Participants consisted of 62 teachers (mean age = 35.8 years; SD = 10.8) teaching in mainstream pre-school centres located in Singapore completed an open-ended survey. Twelve codes were generated and served as guidelines for coding the qualitative data. Codes with similar themes were then grouped to form four construct categories: social communication, restricted and repetitive behaviours, attention and learning and others.

Findings
Results indicated that difficulty with change/transition and social/peer interaction were the most concerning issues across all settings, whereas “lesson time” and “circle time” were the two most common activities/settings in which the concerns were reported by teachers.

Originality/value
Findings from this paper may add to the limited research looking at the challenging behaviours exhibited by children with ASD in mainstream pre-school settings in Singapore. Understanding the type of challenging behaviours presented in pre-schoolers with ASD and the activities/settings in which these behaviours occur may help the teachers to link the difficulties to specific interventions to further support their inclusion in a mainstream pre-school setting.
How harmonious family encourages individuals to enter entrepreneurship
Authors: Zhu Weichun , Zhou Jinyi , Lau Wai Kwan (Elaine) , Welch Steve 
Published: March 2020

PurposeThe purpose of this paper is to examine the roles of one’s original family and current family in influencing his or her entering entrepreneurial endeavors. Specifically, individuals’ original family is also crucial for entrepreneurship, which has been neglected by prior studies to a large extent. Moreover, the authors argue that a good marital relationship between two parents within the original family could facilitate an entrepreneurial spirit by providing better family support, whereas a good relationship with one’s life partner or spouse within their current family could also increase the likelihood of entrepreneurial activities through reducing work stress.Design/methodology/approachThe authors use two archival data sets: National Longitudinal Survey of Youth 1997 and 2013 Global Entrepreneurship Monitor Adult Population Survey to test whether a harmonious relationship between two parents or with life partner/spouse could encourage individuals to become an entrepreneur and whether family support and work conflict mediate such a relationship.FindingsThis study found that parents’ relationship in one’s adolescence provides individuals with more support, which leads to more entrepreneurial endeavors, whereas the conflicts between two parents will reduce their likelihood of initiating entrepreneurial activities. Besides, a good relationship with one’s life partner/spouse can release his/her work stress, which is also important for entrepreneurship development.Originality/valueDifferent from the extant related research that focuses more on on-site predictors of entrepreneurship, the current study proposes factors from other life domains, including those in one’s adolescence, that can also influence and change individuals’ choice of entrepreneurial activities throughout their entire life. Harmonious family relationships (i.e. fewer family conflicts) are important for one to start a business, and family conflicts can reduce the likelihood of choosing entrepreneurship as the main occupation.
Developing sustainable arrangements for “proactive” disaster risk financing in Java, Indonesia
Authors: Soetanto Robby , Hermawan Ferry , Milne Alistair , Hatmoko Jati Utomo Dwi , As'ad Sholihin , He Chusu 
Published: March 2020

Purpose
Recent years saw a paradigm shift from ex post (reactive) to ex ante (proactive) approaches (e.g. insurance) to disaster risk financing for building resilience of communities in developing countries. To facilitate adoption, the approaches should be adapted so that they can be technically feasible and culturally desirable to the local context. This paper aims to report an exploratory study to elaborate the existing arrangements to deal with the impacts of disaster and the potential to shift to a more proactive disaster risk financing in Indonesia.

Design/methodology/approach
A series of stakeholder engagement activities in Semarang and Solo, Indonesia was conducted to ascertain the existing arrangements for disaster risk financing at local government level, the challenges/barriers to the adoption of insurance, education and policies to facilitate the transformation from reactive to proactive process. Thematic analysis was applied to transcribed conversations during interviews, focus groups and workshops. Identification of emerging issues/themes was also guided by the researchers’ notes during the events, and facilitated by qualitative analysis software, Atlas Ti®. This was complemented by an analysis of regulations and documents provided by the local stakeholders.

Findings
The local governments heavily rely on contingency fund, which is not enough and often significantly delayed to fund recovery and reconstruction of public infrastructure. The use of insurance is limited in both public and private sectors, particularly in the majority of low-income communities. Various barriers and challenges were identified under several categories, namely, institutional, cultural, affordability, lack of awareness and knowledge, insurance arrangement process and lack of trust. The findings also suggest that improving insurance education should involve multiple stakeholders, and both formal and informal routes should be pursued.

Originality/value
The research fills the gap of knowledge in disaster risk financing in the context of developing countries, specifically in local governments and communities in Indonesia. The findings may be replicable for other developing countries with low adoption of ex ante financial instruments for dealing with the impacts of disaster.
Good practices of labor welfare and environmental protection in potato crops in Colombia
Authors: Aguilar Olivera Albeiro Alberto , Salas Suárez Saúl Tomás 
Published: March 2020

PurposeThe purpose of this article is to investigate the labor and environmental risks that exist in potato crops in an agricultural area of Colombia and to propose good labor and environmental welfare practices.Design/methodology/approachThe study was conducted through the combination of quantitative and qualitative research approaches, applying pragmatic techniques and tools such as direct observation by field journal, questionnaire survey, checklist of working conditions and a specific methodology for the risk assessment.FindingsIt is identified that the production practices carried out by the cultivators studied are rudimentary, that the agrochemicals used affect the health and safety of the farmers and their families, constituting high-risk products for people and the environment. On the other hand, it is established that the training and qualification of workers is low, they do not use protection elements, or they are not adequate, representing a considerable degree of vulnerability.Originality/valueWith the findings of this research it is expected to improve the working conditions of potato growers and sustainability of agricultural processes in the area, whose results will also be very useful for the analysis of the issue throughout the agricultural sector in general, at a national or international level. Contributing in the same way to the fulfillment of the goals of the sustainable development goals.
Improving sustainability performance through supplier relationship management in the tobacco industry
Authors: Adesanya Ayotunde , Yang Biao , Bin Iqdara Farok Wanes , Yang Ying 
Published: March 2020

PurposeThe purpose of this study is to explore how tobacco manufacturing companies can improve their sustainability performance via effective supplier relationship management (SRM).Design/methodology/approachThis study has adopted a single case study of an international tobacco company. The primary data involved semi-structured interviews with participants from the case company who are familiar with sustainable SRM in the tobacco industry and are engaging in various techniques to improve sustainability performance.FindingsThe drivers for sustainable SRM commonly identified in literature are observable within the case company. There is also clear evidence of integrating sustainability in its SRM processes. However, the perception of sustainability as a requirement to meet stringent regulations limits its scope and drive in pursuing sustainable SRM. It has also limited supplier sustainability evaluation and performance metrics. Furthermore, the findings of this paper reinforce the importance of a procurement team’s ability to work with other functional teams in implementing sustainable SRM. The findings also contribute to the emerging literature on the impact of sustainability on supplier segmentation and multi-tier supplier management.Research limitations/implicationsThis study provides insight into the varying SRM methods used in the tobacco industry to ensure compliance and improve sustainability performance. However, further research is required to explore the generalisability of the findings of this study derived from a single case study.Originality/valueThe tobacco industry is an under-researched industry, particularly in terms of sustainable operations and supply chain management practices. The findings of this study seem to be relevant to those comparable industries with stringent regulations as well.
Sarbanes‐Oxley Act and the acquisition of private targets
Authors: Bhabra Gurmeet S. , Bhabra Harjeet S. , Hossain Ashrafee T. 
Published: March 2020

AbstractUsing a sample of private targets of public acquirers in the US, we find that after the passage of the Sarbanes Oxley Act, acquirer announcement returns are lower, targets are larger, suffer from lower valuation discounts, and receive higher acquisition premiums relative to similar acquisitions pre‐SOX. In addition, acquirer returns are negatively related to proxies for the private target's readiness to comply with SOX Section 404 (quality of internal controls). Our evidence suggests that post‐SOX, private targets are less opaque, have lower valuation uncertainty, and enjoy stronger bargaining position resulting from tighter internal controls around reporting and disclosure.
Lipiodol visibility under ultrasound
Authors: Zen Monica , Kirby Adrienne , Dowthwaite Sarah , Gibson Rowena , Mizia Karen 
Published: March 2020

BackgroundLipiodol is an oil‐based solution commonly used in hysterosalpingogram (HSG), but not hysterosalpingo contrast sonography (HyCoSy). In women with unexplained infertility, evidence suggests that tubal flushing with Lipiodol results in improved fertility post‐procedure. We propose that Lipiodol can be visualised under ultrasound similar to commonly used saline, and hence utilised for HyCoSy, allowing the benefit of an oil‐based tubal flushing to occur with HyCoSy.AimsTo examine whether Lipiodol is visible sonographically, assess optimal agitated Lipiodol mix and ultrasound settings for visibility, and compare visibility to agitated saline, routinely used for HyCoSy.Materials and MethodsTwo separate sonographers with identical ultrasound machines and model pelvises recorded images with varying degrees of agitated Lipiodol and ultrasound settings, in addition to capturing images with no fluid and agitated saline. Each test was performed in quadruplicate and in random order. Images were read by 47 blinded reporters and visibility reported on a scale of one (not visible) to five (clearly visible).ResultsThe mean visibility score for images captured where the Lipiodol sample was agitated five times prior to injection to allow the formation of air microbubbles, regardless of ultrasound setting, were higher than or not different from that for agitated saline (all P > 0.7 when not different, <0.001 when higher).ConclusionsSonographic visualisation of agitated Lipiodol is similar or better than that of agitated saline. Lipiodol may therefore present a possibility for use with HyCoSy, with the added benefit of oil‐based tubal flushing, avoiding the radiation exposure of HSG and concurrently providing pelvic soft‐tissue evaluation.
Youth’s Sibling Relationships Across the Course of a Parent’s Military Deployment: Trajectories and Implications
Authors: Whiteman Shawn D. , Hamwey Meghan K. , Topp Dave , MacDermid Wadsworth Shelley 
Published: March 2020

The present exploratory study explored the trajectories and implications of at‐home (military unaffiliated) parents’ perceptions of youth’s sibling relationships across the course of a parent’s military deployment. Participants included 109 families with at least two siblings (older sibling and younger siblings age: M = 10.85, SD = 3.92 and M = 7.89, SD = 3.58, respectively) and one parent serving in the National Guard. Data were collected via in‐home interviews, at six time points across the deployment cycle. A series of multilevel models revealed increases in sibling disharmony during the months a deployed parent was away, but showed signs of recovery in the year after they returned. Increases in sibling disharmony were positively associated with increases in youth’s externalizing behaviors above and beyond the effects of parenting.
Knowledge exchange, foster care and early education: Introducing treasure baskets to foster carers of young children
Authors: Cameron Claire , Meetoo Veena , Johansen Thure , Jackson Sonia 
Published: March 2020

AbstractAll children have a right to early childhood education, but preschool‐aged fostered children are less likely than others to access formal early childhood education and care (ECEC) services such as nurseries and playgroups. The home learning environment is crucial for this group. Building on an earlier pilot study where foster carers of young children saw education as something that largely happens outside the home, this paper presents a knowledge exchange project that aimed to build foster carers' self‐concept as educators. The design of the project aimed to exchange knowledge between academic researchers and practitioners through an experientially based training programme, which focused on extending the specific ECEC practice of treasure baskets. The programme was theoretically grounded in social pedagogy, which takes an educative approach to social issues. Although there were clear difficulties in recruitment, there were promising signs that the knowledge exchange dialogic approach promoted the acquisition of new knowledge and skills and enhanced foster carers' sense of self‐confidence as educators for the young children they look after.
Thrown back: Reintegration experiences of National Guard/Reserve mothers of young children
Authors: Nicholson Juliann H. , DeVoe Ellen R. 
Published: March 2020

AbstractFew studies have examined the experiences and perceptions of servicewoman mothers and their children, even as an increasing number of them have experienced deployment and combat exposure. The present paper describes a qualitative study that explored National Guard/Reserve (NG/R) mothers' experiences with mothering and co‐parenting during reintegration and their perceived priorities, supports, challenges and needs. Interpretive phenomenological analysis of seven in‐depth qualitative interviews produced themes including reunion and loneliness, the importance of time, help seeking and gendered experiences. Notably, all participants transitioned immediately back into primary caregiver roles upon homecoming, and several described how difficult it was to readjust while privately dealing with unmet mental health needs. Findings underscore the importance of a flexible suite of service options that meet key needs, most importantly, child care, social–emotional support for children and peer‐based parenting support specific to servicewoman mothers. For NG/R mothers, who may live far from base, community‐based services are essential, but as participants described, civilian social workers and other professionals must develop specialized knowledge, skills and experience to provide appropriate support.