bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations
Authors: Li Mengying , Rahman Mohammad L , Wu Jing , Ding Ming , Chavarro Jorge E , Lin Yuan , Ley Sylvia H , Bao Wei , Grunnet Louise G , Hinkle Stefanie N , Thuesen Anne Cathrine B , Yeung Edwina , Gore-Langton Robert E , Sherman Seth , Hjort Line , Kampmann Freja Bach , Bjerregaard Anne Ahrendt , Damm Peter , Tekola-Ayele Fasil , Liu Aiyi , Mills James L , Vaag Allan , Olsen Sjurdur F , Hu Frank B , Zhang Cuilin 
Published: February 2020

ObjectiveWomen with a history of gestational diabetes mellitus (GDM) have an exceptionally high risk for type 2 diabetes (T2D). Yet, little is known about genetic determinants for T2D in this population. We examined the association of a genetic risk score (GRS) with risk of T2D in two independent populations of women with a history of GDM and how this association might be modified by non-genetic determinants for T2D.Research design and methodsThis cohort study included 2434 white women with a history of GDM from the Nurses’ Health Study II (NHSII, n=1884) and the Danish National Birth Cohort (DNBC, n=550). A GRS for T2D was calculated using 59 candidate single nucleotide polymorphisms for T2D identified from genome-wide association studies in European populations. An alternate healthy eating index (AHEI) score was derived to reflect dietary quality after the pregnancy affected by GDM.ResultsWomen on average were followed for 21 years in NHSII and 13 years in DNBC, during which 446 (23.7%) and 155 (28.2%) developed T2D, respectively. The GRS was generally positively associated with T2D risk in both cohorts. In the pooled analysis, the relative risks (RRs) for increasing quartiles of GRS were 1.00, 0.97, 1.25 and 1.19 (p trend=0.02). In both cohorts, the association appeared to be stronger among women with poorer (AHEI <median) than better dietary quality (AHEI ≥median), although the interaction was not significant. For example, in NHSII, the RRs across increasing quartiles of GRS were 1.00, 0.99, 1.51 and 1.29 (p trend=0.06) among women with poorer dietary quality and 1.00, 0.83, 0.81 and 0.94 (p trend=0.79) among women with better dietary quality (p interaction=0.11).ConclusionsAmong white women with a history of GDM, higher GRS for T2D was associated with an increased risk of T2D.
ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis
Authors: Capoulade Romain , Torzewski Michael , Mayr Manuel , Chan Kwan-Leung , Mathieu Patrick , Bossé Yohan , Dumesnil Jean G , Tam James , Teo Koon K , Burnap Sean A. , Schmid Jens , Gobel Nora , Franke Ulrich F W , Sanchez Amber , Witztum Joseph L , Yang Xiaohong , Yeang Calvin , Arsenault Benoit , Després Jean-Pierre , Pibarot Philippe , Tsimikas Sotirios 
Published: February 2020

ObjectiveThis study assessed whether apolipoprotein CIII-lipoprotein(a) complexes (ApoCIII-Lp(a)) associate with progression of calcific aortic valve stenosis (AS).MethodsImmunostaining for ApoC-III was performed in explanted aortic valve leaflets in 68 patients with leaflet pathological grades of 1–4. Assays measuring circulating levels of ApoCIII-Lp(a) complexes were measured in 218 patients with mild–moderate AS from the AS Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) trial. The progression rate of AS, measured as annualised changes in peak aortic jet velocity (Vpeak), and combined rates of aortic valve replacement (AVR) and cardiac death were determined. For further confirmation of the assay data, a proteomic analysis of purified Lp(a) was performed to confirm the presence of apoC-III on Lp(a).ResultsImmunohistochemically detected ApoC-III was prominent in all grades of leaflet lesion severity. Significant interactions were present between ApoCIII-Lp(a) and Lp(a), oxidised phospholipids on apolipoprotein B-100 (OxPL-apoB) or on apolipoprotein (a) (OxPL-apo(a)) with annualised Vpeak(all p<0.05). After multivariable adjustment, patients in the top tertile of both apoCIII-Lp(a) and Lp(a) had significantly higher annualised Vpeak(p<0.001) and risk of AVR/cardiac death (p=0.03). Similar results were noted with OxPL-apoB and OxPL-apo(a). There was no association between autotaxin (ATX) on ApoB and ATX on Lp(a) with faster progression of AS. Proteomic analysis of purified Lp(a) showed that apoC-III was prominently present on Lp(a).ConclusionApoC-III is present on Lp(a) and in aortic valve leaflets. Elevated levels of ApoCIII-Lp(a) complexes in conjunction with Lp(a), OxPL-apoB or OxPL-apo(a) identify patients with pre-existing mild–moderate AS who display rapid progression of AS and higher rates of AVR/cardiac death.Trial registrationNCT00800800.
Blunted circulating irisin in adults with type 1 diabetes during aerobic exercise in a hot environment: a pilot study
Authors: McCormick James J. , Notley Sean R. , Yardley Jane E. , Sigal Ronald J. , Kenny Glen P. 
Published: February 2020

Irisin is a novel myokine associated with increased metabolism, which may be upregulated in type 1 diabetes (T1D) during exercise-heat stress. We therefore assessed serum irisin production in young adults with and without T1D during incremental exercise in dry-heat (35 °C). The change in irisin during exercise was lower in individuals with compared with without T1D (−1.79 (SEM 25.68) vs. 59.74 (SEM 79.63) pg/mL; p = 0.024), indicating that irisin expression during exercise-heat stress is blunted in T1D. Novelty We show that, when assessed in young adults with and without T1D during exercise-heat stress, serum irisin production is blunted in T1D.
Life stress and background anxiety are not associated with resting metabolic rate in healthy adults
Authors: Wilson Patrick B. , Wynne Jaison L. , Ehlert Alex M. , Mowfy Zachary 
Published: February 2020

This study examined associations between anxiety, stress, and resting metabolic rate (RMR). Thirty women and 23 men had RMR measured at two visits. Participants also had body composition assessed and completed several questionnaires: State–Trait Inventory for Cognitive and Somatic Anxiety (STICSA), Anxiety Sensitivity Index (ASI)-3, and Perceived Stress Scale (PSS)-14. The state version of the STICSA was completed at both visits, while the other questionnaires were completed at visit one. RMR was expressed in kilocalories per day and relative to lean mass (RMRrelative). Participants were divided into low-, medium-, and high-anxiety groups based on STICSA trait scores, and RMR was compared among groups using one-way ANOVA. Changes between visits were evaluated using paired t tests and Wilcoxon signed-rank tests. RMR did not change from visit one to visit two (1589 to 1586 kcal/day, p = 0.86) even though STICSA state scores slightly declined (Z-statistic = –2.39, p = 0.017). RMRrelative values were 30.3 ± 3.7, 29.0 ± 1.9, and 29.9 ± 3.6 kcal/kg of lean mass among low, medium, and high trait anxiety groups, respectively (F = 0.70, p = 0.50). No RMR variable significantly correlated with PSS-14, ASI-3, or STICSA scores. This study provides evidence that trait anxiety and life stress do not impact RMR. Whether an association between these factors exists in anxiety disorders remains to be evaluated. Novelty Contrary to previous research, this study found no associations between anxiety and RMR. It is doubtful whether practitioners need to account for healthy subjects’ trait anxiety and stress when analyzing RMR data.
Impact of generalized polytropic equation of state on charged anisotropic polytropes
Authors: Mardan S. A. , Rehman M. , Noureen I. , Jamil R. N. 
Published: February 2020

AbstractIn this paper, generalized polytropic equation of state is used to get new classes of polytropic models from the solution of Einstein-Maxwell field equations for charged anisotropic fluid configuration. The models are developed for different values of polytropic index $$n=1,~\frac{1}{2},~2$$n=1,12,2. Masses and radii of eight different stars have been regained with the help of developed models. The speed of sound technique and graphical analysis of model parameters is used for the viability of developed models. The analysis of models indicates they are well behaved and physically viable.
Interview with Belinda Barnet
Authors: Atzenbeck Claus 
Published: February 2020

Belinda Barnet is Senior Lecturer in Media & Communications at Swinburne University, Melbourne. She is the author of "Memory Machines: the Evolution of Hypertext" (Anthem Press UK, 2013), which can be obtained, e.g., via https://amzn.to/2KjqlYH.
Alongside her research career, Dr Barnet has worked as Service Delivery Manager (Wireless Content Services) for Ericsson Australia. She convenes the Social Media Major at Swinburne (https://bit.lv/312ARJY).
Her current projects include building a speech recognition program to help young children and toddlers with Cochlear Implants learn to speak, and she'd be interested in hearing from anyone working in this field.
She's also investigating Shadow Data.
Inference and analysis of gene regulatory networks using data mining techniques
Authors: Ahmed Syed Sazzad , Roy Swarup 
Published: February 2020

Causality draws the relationship between the cause and the effect among a pair of items. Causality inference in Gene Regulatory Networks (GRNs) is a challenging task due to the limits of appropriate data and large dataset size of real networks. Such an inference is very important because it might give the blueprint of how a complex organism operates which might further reveal the probable cause of some of the terminal diseases. A number of techniques have been proposed and applied to infer causal relationships in various domains. However, they are not specific to regulatory network inference.
In our work, we made an empirical study on a few selective methods in inferring causal GRNs. To assess the candidate methods in terms of their quality of inference we used time-series expression data from the DREAM challenges. Our findings revealed that among the selected causality finding techniques, Causation Entropy gives the best result, however, it is computationally expensive. We used the second-best approach, Transfer Entropy, to infer casual GRN of breast cancer datasets. The topological analysis of the network revealed that top out-degree genes such as SLC39A5 which are considered central genes, plays an important role in cancer progression.
The main intention behind this research work was to develop an effective inference method for causal Gene Regulatory Network which is computationally less expensive and also considers the effects of time-delay during regulation of one gene by the other. We proposed a novel time delayed inferring method for GRNs using association rule mining. We tried to infer the regulatory sign of the edges i.e. whether influencing positively or negatively. Comparative results highlight that our proposed technique produced better inference results in comparison to several of the existing techniques.

We applied the proposed method to perform post inference analysis on malignant cancer network and benign network. Various networks parameters like the degree distribution, average path length, clustering coefficient, network re-wiring structure analysis, network topological variation analysis, and connectivity variation analysis are performed to identify the differentially expressed genes between the two networks. To avoid inference biasness and to obtain a consensus based conclusion we made a comparative analysis between our proposed method and transfer entropy based method and also computed the average score. Such an analysis of the network has revealed four genes, namely, STON
2
, UMODL
1
, STK
11
, and COBL which are already under investigation for its role in various types of cancer as seen from various researches.
LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance
Authors: Roberts Melyssa S. , Sahni Jennifer M. , Schrock Morgan S. , Piemonte Katrina M. , Weber-Bonk Kristen L. , Seachrist Darcie D. , Avril Stefanie , Anstine Lindsey J. , Singh Salendra , Sizemore Steven T. , Varadan Vinay , Summers Matthew K. , Keri Ruth A. 
Published: February 2020

Abstract

A significant therapeutic challenge for patients with cancer is resistance to chemotherapies such as taxanes. Overexpression of LIN9, a transcriptional regulator of cell-cycle progression, occurs in 65% of patients with triple-negative breast cancer (TNBC), a disease commonly treated with these drugs. Here, we report that LIN9 is further elevated with acquisition of taxane resistance. Inhibiting LIN9 genetically or by suppressing its expression with a global BET inhibitor restored taxane sensitivity by inducing mitotic progression errors and apoptosis. While sustained LIN9 is necessary to maintain taxane resistance, there are no inhibitors that directly repress its function. Hence, we sought to discover a druggable downstream transcriptional target of LIN9. Using a computational approach, we identified NIMA-related kinase 2 (NEK2), a regulator of centrosome separation that is also elevated in taxane-resistant cells. High expression of NEK2 was predictive of low survival rates in patients who had residual disease following treatment with taxanes plus an anthracycline, suggesting a role for this kinase in modulating taxane sensitivity. Like LIN9, genetic or pharmacologic blockade of NEK2 activity in the presence of paclitaxel synergistically induced mitotic abnormalities in nearly 100% of cells and completely restored sensitivity to paclitaxel, in vitro. In addition, suppressing NEK2 activity with two distinct small molecules potentiated taxane response in multiple in vivo models of TNBC, including a patient-derived xenograft, without inducing toxicity. These data demonstrate that the LIN9/NEK2 pathway is a therapeutically targetable mediator of taxane resistance that can be leveraged to improve response to this core chemotherapy.

Significance:
Resistance to chemotherapy is a major hurdle for treating patients with cancer. Combining NEK2 inhibitors with taxanes may be a viable approach for improving patient outcomes by enhancing mitotic defects induced by taxanes alone.
Pharmacodynamic Analysis of BTK Inhibition in Patients with Chronic Lymphocytic Leukemia Treated with Acalabrutinib
Authors: Alsadhan Anfal , Cheung Jean , Gulrajani Michael , Gaglione Erika M. , Nierman Pia , Hamdy Ahmed , Izumi Raquel , Bibikova Elena , Patel Priti , Sun Clare , Covey Todd , Herman Sarah E.M. , Wiestner Adrian 
Published: February 2020

Abstract

Purpose:
To determine the pharmacodynamic relationship between target occupancy of Bruton tyrosine kinase (BTK) and inhibition of downstream signaling.

Patients and Methods:
Patients with chronic lymphocytic leukemia (CLL) enrolled in a phase II clinical trial (NCT02337829) with the covalent, selective BTK inhibitor acalabrutinib donated blood samples for pharmacodynamic analyses. Study design included randomization to acalabrutinib 100 mg twice daily or 200 mg once daily and dose interruptions on day 4 and 5 of the first week. BTK occupancy and readouts of intracellular signaling were assessed sequentially between 4 and 48 hours from last dose.

Results:
Four hours from last dose, BTK occupancy exceeded 96% and at trough, was higher with twice daily, median 95.3%, than with once daily dosing, median 87.6% (P &lt; 0.0001). By 48 hours from last dose, median free BTK increased to 25.6%. Due to covalent binding of acalabrutinib, free BTK is generated by de novo synthesis. The estimated rate of BTK synthesis varied widely between patients ranging from 3.6% to 31.4% per day. Acalabrutinib reduced phosphorylation of BTK and inhibited downstream B-cell receptor (BCR) and NFκB signaling. During dosing interruptions up to 48 hours, expression of BCR target genes rebounded, while phosphorylation of signaling molecules remained repressed. In vitro cross-linking of IgM on CLL cells obtained 36 to 48 hours from last dose upregulated CD69, with high correlation between cellular free BTK and response (R = 0.7, P ≤ 0.0001).

Conclusions:
Higher BTK occupancy was achieved with twice daily over once daily dosing, resulting in deeper and more sustained inhibition of BCR signaling.
Ontogenetic and sexual variation in the sagitta otolith of Menticirrhus americanus (Teleostei; Sciaenidae) (Linnaeus, 1758) in a subtropical environment
Authors: Carvalho Barbara Maichak de , Volpedo Alejandra Vanina , Fávaro Luís Fernando 
Published: February 2020

This study aimed to verify variations in the form of the sagitta otolith of Menticirrhus americanus as to their ontogeny, sex and stage of such structure. Ontogenetically were found significant differences (p < 0.05) for all shape indices (aspect ratios, shape factor, rectangularity, ellipticity, relative surface of sulcus acusticus) and also in the wavelet of the otolith. The CVA presented a 98.6% correct reclassification of the otolith between interval class. Sexual variations were found in the wavelet and in the relative surface of sulcus acusticus index. Between adult females and young females, differences were not detected in the wavelet and rectangularity, but significant differences were found in all other shape indices. The CVA presented a 79.6% correct reclassification of the otolith of the sexes and stages of life sampled. Young females and adults females showed highest correct percentage of classification. The results of this study demonstrate for the first time the influence of the ontogenetic variation and sexual in the form of the otoliths.
A new synonym and seventeen new distributional records in South American Cerambycidae (Coleoptera), with notes on Chlorethe scabrosa Zajciw, 1963
Authors: Santos-Silva Antonio , Botero Juan Pablo , Nascimento Francisco Eriberto de Lima , Silva Weliton Dias 
Published: February 2020

We studied 18 cerambycid beetle species native to South America. Seventeen represent new state records in Brazil. Particularly, Chlorethe scabrosa Zajciw, 1963 is newly reported for the state of Rio de Janeiro with exclusion of C. brachyptera Zajciw, 1963. The Brazilian state of the type locality of Dufauxia guaicurana Lane, 1955 is fixed. Pirangoclytus mendosus (Galileo & Martins, 1996) is synonymized with P. mniszechii (Chevrolat, 1862), and its holotype is a female. Variation on Trypanidius maculatus Monné & Delfino, 1980 is commented. New country and department records for Paraguay are also provided.
Description of a new species of Dascillus Latreille from Henan, China (Coleoptera: Dascillidae)
Authors: FANG YAN , YAN YIJIE , JIN ZHENYU 
Published: February 2020

Dascillus Latreille, 1797 (Coleoptera: Dascillidae) currently contains about 40 species, of which 32 have been reported from China (Jin et al. 2013, 2018; Hájek 2016; Terzani et al. 2017; Wang et al. 2019). The Baotianman National Nature Reserve of Henan (33°20ʹ–33°36ʹN, 111°47ʹ–112°04ʹE) which is one of the “world biosphere reserves” recognized by United Nations Educational, Scientific and Cultural Organization for their high ecosystem and species diversity (Zhu et al. 2002). While examining specimens collected from the survey of the Baotianman National Nature Reserve in 2017, conducted by the Hunan Agricultural University (Changsha, China), a new species of Dascillus was identified and is described in this paper.
NEED: The Northern European Enclosure Dam for if Climate Change Mitigation Fails
Authors: Groeskamp Sjoerd , Kjellsson Joakim 
Published: February 2020

AbstractIt might be impossible to truly fathom the magnitude of the threat that global-mean sea level rise poses. However, conceptualizing the scale of the solutions required to protect ourselves against global-mean sea level rise aids in our ability to acknowledge and understand that threat. On these grounds, we here discuss a means to protect over 25 million people and important economical regions in northern Europe against sea level rise. We propose the construction of a Northern European Enclosure Dam (NEED) that stretches between France, the United Kingdom, and Norway. NEED may seem an overwhelming and unrealistic solution at first. However, our preliminary study suggests that NEED is potentially favorable financially, but also in scale, impacts, and challenges compared to that of alternative solutions, such as (managed) migrations and that of country-by-country protection efforts. The mere realization that a solution as considerable as NEED might be a viable and cost-effective protection measure is illustrative of the extraordinary global threat of global-mean sea level rise that we are facing. As such, the concept of constructing NEED showcases the extent of protection efforts that are required if mitigation efforts fail to limit sea level rise.
Forecasting the Past: Views of Earth from the Moon and Beyond
Authors: Lopez Philippe 
Published: February 2020

AbstractAs we celebrate the fiftieth anniversary of NASA’s Apollo missions, images of Earth simulated with the ECMWF Integrated Forecasting System (IFS) are visually compared with pictures collected during space missions of the past five decades, in particular from the Apollo missions (1968–72). The numerical weather reforecasts use the latest version of the IFS and are initialized from (re)analysis data, which provide our current best representation of the atmospheric state for any given date back to the 1950s. Visible images of our planet are produced from the IFS with a simple simulator whose main inputs are the solar fluxes at the top of the atmosphere. First, a comparison to recent imagery from deep space illustrates the high level of performance of the IFS on recent dates. Then, the validation of the IFS against photographs taken by Apollo 11 and 17 both in-flight and from the lunar surface exhibits a significant level of agreement, despite the absence or very limited number of satellite observations available. This short study confirms that the combination of high-quality initial conditions with a modern numerical weather prediction model can yield reasonably accurate reforecasts of global meteorological conditions, especially cloud systems, for dates as far back as the late 1960s.