bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for intraoperative greater trochanteric fractures in hemiarthroplasty for intracapsular femoral neck fractures
Authors: Fakler Johannes Karl Maria , Brand Alexander , Lycke Christian , Pempe Christina , Ghanem Mohamed , Roth Andreas , Osterhoff Georg , Spiegl Ulrich Josef Albert , Höch Andreas , Zajonz Dirk 
Published: December 2020

Abstract
Purpose
Hemiarthroplasty is widely accepted as the treatment of choice in elderly patients with a displaced intracapsular femoral neck fracture. Intraoperative greater trochanteric fractures thwart this successful procedure, resulting in prolonged recovery, inferior outcome, and increased risk of revision surgery. Hence, this study analyzed factors potentially associated with an increased risk for intraoperative greater trochanteric fracture.

Methods
This retrospective study included 512 hemiarthroplasties in 496 patients with a geriatric intracapsular femoral neck fracture from July 2010 to March 2020. All patients received the same implant type of which 90.4% were cemented and 9.6% non-cemented. Intra- and postoperative radiographs and reports were reviewed and particularly screened for greater trochanteric fractures.

Results
Female patients accounted for 74% and mean age of the patients was 82.3 (± 8.7) years. 34 (6.6%) intraoperative greater trochanteric fractures were identified. In relation to patient-specific factors, only a shorter prothrombin time was found to be significantly associated with increased risk of intraoperative greater trochanteric fracture (median 96%, IQR 82–106% vs. median 86.5%, IQR 68.8–101.5%; p = 0.046). Other factors associated with greater trochanteric fracture were a shorter preoperative waiting time and changes in perioperative settings. Outcome of patients with greater trochanteric fracture was worse with significantly more surgical site infection requiring revision surgery (17.6% vs. 4.2%, p = 0.005).

Conclusion
Prolonged prothrombin time, a shorter preoperative waiting time, and implementing new procedural standards and surgeons may be associated with an increased risk of a greater trochanteric fracture. Addressing these risk factors may reduce early periprosthetic infection which is strongly related to greater trochanteric fractures.
The thymus medulla and its control of αβT cell development
Authors: Cosway Emilie J. , James Kieran D. , Lucas Beth , Anderson Graham , White Andrea J. 
Published: December 2020

AbstractαβT cells are an essential component of effective immune responses. The heterogeneity that lies within them includes subsets that express diverse self-MHC-restricted αβT cell receptors, which can be further subdivided into CD4+ helper, CD8+ cytotoxic, and Foxp3+ regulatory T cells. In addition, αβT cells also include invariant natural killer T cells that are very limited in αβT cell receptor repertoire diversity and recognise non-polymorphic CD1d molecules that present lipid antigens. Importantly, all αβT cell sublineages are dependent upon the thymus as a shared site of their development. Ongoing research has examined how the thymus balances the intrathymic production of multiple αβT cell subsets to ensure correct formation and functioning of the peripheral immune system. Experiments in both wild-type and genetically modified mice have been essential in revealing complex cellular and molecular mechanisms that regulate thymus function. In particular, studies have demonstrated the diverse and critical role that the thymus medulla plays in shaping the peripheral T cell pool. In this review, we summarise current knowledge on functional properties of the thymus medulla that enable the thymus to support the production of diverse αβT cell types.
Ecophysiological and ultrastructural characterisation of the circumpolar orange snow alga Sanguina aurantia compared to the cosmopolitan red snow alga Sanguina nivaloides (Chlorophyta)
Authors: Procházková Lenka , Remias Daniel , Holzinger Andreas , Řezanka Tomáš , Nedbalová Linda 
Published: December 2020

AbstractRed snow caused by spherical cysts can be found worldwide, while an orange snow phenomenon caused by spherical cells is restricted to (Sub-)Arctic climates. Both bloom types, occurring in the same localities at Svalbard, were compared ecophysiologically. Using a combination of molecular markers and light- and transmission electron microscopy, cells were identified as Sanguina nivaloides and Sanguina aurantia (Chlorophyceae). In search for reasons for a cosmopolitan vs. a more restricted distribution of these microbes, significant differences in fatty acid and pigment profiles of field samples were found. S. aurantia accumulated much lower levels of polyunsaturated fatty acids (21% vs. 48% of total fatty acids) and exhibited lower astaxanthin-to-chlorophyll-a ratio (2–8 vs. 12–18). These compounds play an important role in adaptation to extreme conditions at the snow surface and within snow drifts. Accordingly, the performance of photosystem II showed that one third to nearly half of the photosynthetic active irradiation was sufficient in S. aurantia, compared to S. nivaloides, to become light saturated. Furthermore, formation of plastoglobules observed in S. nivaloides but missing in S. aurantia may contribute to photoprotection. The rapid light curves of the two species show to a certain extent the shade-adapted photosynthesis under the light conditions at Svalbard (high α-value 0.16 vs. 0.11, low saturation point Ik 59 vs. 86). These results indicate significant physiological and ultrastructural differences of the two genetically closely related cryoflora species, but the reasons why S. aurantia has not been found at conditions outside (Sub-)Arctic climate types remain unknown.
T1 mapping of the liver and the spleen in patients with liver fibrosis—does normalization to the blood pool increase the predictive value?
Authors: Obmann Verena Carola , Berzigotti Annalisa , Catucci Damiano , Ebner Lukas , Gräni Christoph , Heverhagen Johannes Thomas , Christe Andreas , Huber Adrian Thomas 
Published: December 2020

Abstract
Purpose
To analyze whether the T1 relaxation time of the liver is a good predictor of significant liver fibrosis and whether normalization to the blood pool improves the predictive value.

Methods
This prospective study was conducted between 03/2016 and 02/2018. One hundred seventy-three patients underwent multiparametric liver MRI at 3 T. The T1 relaxation time was measured in the liver and the spleen, in the aorta, the portal vein, and the inferior vena cava (IVC). T1 relaxation times with and without normalization to the blood pool were compared between patients with (n = 26) and without (n = 141) significant liver fibrosis, based on a cutoff value of 3.5 kPa in MRE as the noninvasive reference standard. For statistics, Student’s t test, receiver operating characteristic (ROC) curve analysis, and Pearson’s correlation were used.

Results
The T1 relaxation time of the liver was significantly longer in patients with liver fibrosis, both with and without blood pool normalization (p < 0.001). T1 relaxation time of the liver allowed prediction of significant liver fibrosis (AUC = 0.88), while normalization to the IVC resulted in a slightly lower performance (AUC = 0.82). The lowest performance was achieved when the T1 relaxation times of the liver were normalized to the aorta (AUC = 0.66) and to the portal vein (AUC = 0.62). The T1 relaxation time of the spleen detected significant liver fibrosis with an AUC of 0.68, and 0.51–0.64 with normalization to the blood pool.

Conclusion
The T1 relaxation time of the liver is a good predictor of significant liver fibrosis. However, normalization of the blood pool did not improve the predictive value.

Key Points
• The T1 relaxation time of the liver is a good predictor of significant liver fibrosis.
• Normalization to the blood pool did not improve the predictive value of T1 mapping.
• If the blood pool normalization was weighted 30% to the aorta and 70% to the portal vein, the performance was better than normalization to the aorta alone but still lower than normalization to the IVC.
Validation of an Eulerian Stochastic Fields Solver Coupled with Reaction–Diffusion Manifolds on LES of Methane/Air Non-premixed Flames
Authors: Breda Paola , Yu Chunkan , Maas Ulrich , Pfitzner Michael 
Published: December 2020

AbstractThe Eulerian stochastic fields (ESF) combustion model can be used in LES in order to evaluate the filtered density function to describe the process of turbulence–chemistry interaction. The method is typically computationally expensive, especially if detailed chemistry mechanisms involving hydrocarbons are used. In this work, expensive computations are avoided by coupling the ESF solver with a reduced chemistry model. The reaction–diffusion manifold (REDIM) is chosen for this purpose, consisting of a passive scalar and a suitable reaction progress variable. The latter allows the use of a constant parametrization matrix when projecting the ESF equations onto the manifold. The piloted flames Sandia D–E were selected for validation using a 2D-REDIM. The results show that the combined solver is able to correctly capture the flame behavior in the investigated sections, although local extinction is underestimated by the ESF close to the injection plate. Hydrogen concentrations are strongly influenced by the transport model selected within the REDIM tabulation. A total solver performance increase by a factor of 81% is observed, compared to a full chemistry ESF simulation with 19 species. An accurate prediction of flame F instead required the extension of the REDIM table to a third variable, the scalar dissipation rate.
Theoretical Foundations of Nanoscale Quantum Devices
Authors: Premaratne Malin , Agrawal Govind P. 
Published: December 2020

Nanooptics which describes the interaction of light with matter at the nanoscale, is a topic of great fundamental interest to physicists and engineers and allows the direct observation of quantum mechanical phenomena in action. This self-contained and extensively referenced text describes the underlying theory behind nanodevices operating in the quantum regime for use both in advanced courses and as a reference for researchers in physics, chemistry, electrical engineering, and materials science. Presenting an extensive theoretical toolset for design and analysis of nanodevices, the authors demonstrate the art of developing approximate quantum models of real nanodevices. The rudimentary mathematical knowledge required to master the material is carefully introduced, with detailed derivations and frequent worked examples allowing readers to gain a thorough understanding of the material. More advanced applications are gradually introduced alongside analytical approximations and simplifying assumptions often used to make such problems tractable while representative of the observed features.
Separation and Rare Events
Authors: Beiser-McGrath Liam F. 
Published: December 2020

AbstractWhen separation is a problem in binary dependent variable models, many researchers use Firth's penalized maximum likelihood in order to obtain finite estimates (Firth, 1993; Zorn, 2005; Rainey, 2016). In this paper, I show that this approach can lead to inferences in the opposite direction of the separation when the number of observations are sufficiently large and both the dependent and independent variables are rare events. As large datasets with rare events are frequently used in political science, such as dyadic data measuring interstate relations, a lack of awareness of this problem may lead to inferential issues. Simulations and an empirical illustration show that the use of independent “weakly-informative” prior distributions centered at zero, for example, the Cauchy prior suggested by Gelman et al. (2008), can avoid this issue. More generally, the results caution researchers to be aware of how the choice of prior interacts with the structure of their data, when estimating models in the presence of separation.
The COVID-19 Pandemic, International Cooperation, and Populism
Authors: Pevehouse Jon C.W. 
Published: December 2020

AbstractInconsistent efforts at international cooperation often undermined global efforts to mitigate the COVID-19 health pandemic. Pundits and scholars alike laid much of the blame for this lack of cooperation on domestic political factors, especially populist leaders. Could international relations theories have predicted this behavior? I argue that there are no off-the-shelf theories that engage populism with traditional mechanisms of international cooperation, especially cooperation facilitated by international institutions. I explore how populist sentiment, whether stemming from the public or leaders, can pose barriers to cooperation. I argue that populists are especially likely to resist cues from foreign actors; are especially reticent to delegate national sovereignty; and are especially resistant to policies that result in gains for elites and, when coupled with nationalism, foreigners. The essay concludes with suggestions for further theoretical and empirical research.
Ageing well in a foreign land: group memberships protect older immigrants’ wellbeing through enabling social support and integration
Authors: Haslam Catherine , Dane Sharon , Lam Ben C. P. , Jetten Jolanda , Liu Shuang , Gallois Cindy , Tran Tran Le Nghi 
Published: December 2020

AbstractDespite the numerous challenges of ageing in a foreign land, many older immigrants are fairly resilient and report experiencing good wellbeing. The key question that the present paper addresses is how this is achieved. Drawing on frameworks from cross-cultural and social identity literatures, the present study proposes and tests a model of serial multiple mediation that identifies possible mechanisms supporting the wellbeing of older immigrants who have resided in the host country for some time. In this model, it is predicted that new group memberships acquired post-migration enable access to social support that in turn provides the basis for perceived integration, which enhances wellbeing. This model was tested in a survey study with 102 older people, whose mean age was 80.3 years and who had migrated to Australia from Asian, European, and Central and South American countries on average 36 years previously. The survey assessed cultural identity, social group memberships acquired post-migration, perceived social support, perceived integration and wellbeing. Results supported the hypothesised model, indicating that joining new heritage culture and wider groups in Australia post-migration provided a platform for social support and integration, which enhanced life satisfaction and reduced loneliness. The implications of these findings for theory and adapting successfully to both migration and ageing are discussed.
Ethical dilemmas: balancing choice and risk with a duty of care in extending personalisation into the care home
Authors: Miller Emma , Barrie Karen 
Published: December 2020

AbstractThe article reports the perspectives of senior care staff as part of a study exploring personalisation in care homes. Behind the conceptual sword and shield of ‘choice and control’ associated with personalisation in the United Kingdom (UK) lie irreconcilable flaws, thrown into sharp relief in this context. Personalisation, which originated in community-based social services, has recently been extended into UK care homes. This service development has been stimulated by a desire to promote a humane response to caring for an ageing population, whilst containing costs. Seemingly promoting a relational approach, personalisation also entails consumerist underpinnings, with consequent tensions resulting in weakened policy mechanisms. Discussing findings pertaining to ‘food and eating’, the article illustrates the complex interplay between supporting resident capabilities with poor staff ratios; when choice is not really choice at all; balancing choice, risk and the duty of care; and responding to diverse perspectives about what matters. This complexity reflects the highly skilled nature of care work as promoted by care ethicists. The tensions permeated care home life and found parallels in the wider system of care. Honesty about the limitations of choice and control is essential to achieve ethical care in care homes. The care home constitutes fertile ground for exposing and exploring the shortcomings of the ‘logic of choice’ and for advancing a more relational, inclusive and sustainable conceptualisation of personalisation.
Subclinical atherosclerosis in children and adolescents with congenital heart disease
Authors: Cardoso Silvia M. , Honicky Michele , Moreno Yara M. F. , de Lima Luiz R. A. , Pacheco Matheus A. , Back Isabela de C. 
Published: December 2020

AbstractBackground:Subclinical atherosclerosis in childhood can be evaluated by carotid intima-media thickness, which is considered a surrogate marker for atherosclerotic disease in adulthood. The aims of this study were to evaluate carotid intima-media thickness and, to investigate associated factors.Methods:Cross-sectional study with children and adolescents with congenital heart disease (CHD). Socio-demographic and clinical characteristics were assessed. Subclinical atherosclerosis was evaluated by carotid intima-media thickness. Cardiovascular risk factors, such as physical activity, screen time, passive smoke, systolic and diastolic blood pressure, waist circumference, dietary intake, lipid parameters, glycaemia, and C-reactive protein, were also assessed. Factors associated with carotid intima-media thickness were analysed using multiple logistic regression.Results:The mean carotid intima-media thickness was 0.518 mm and 46.7% had subclinical atherosclerosis (carotid intima-media thickness ≥ 97th percentile). After adjusting for confounding factors, cyanotic CHD (odds ratio: 0.40; 95% confidence interval: 0.20; 0.78), cardiac surgery (odds ratio: 3.17; 95% confidence interval: 1.35; 7.48), and be hospitalised to treat infections (odds ratio: 1.92; 95% confidence interval: 1.04; 3.54) were associated with subclinical atherosclerosis.Conclusion:Clinical characteristics related to CHD were associated with subclinical atherosclerosis. This finding suggests that the presence of CHD itself is a risk factor for subclinical atherosclerosis. Therefore, the screen and control of modifiable cardiovascular risk factors should be made early and intensively to prevent atherosclerosis.
The use of aperture shape controller and convergence mode in radiotherapy treatment planning
Authors: Rossi Maija , Boman Eeva 
Published: December 2020

AbstractAim:Studying the use of Aperture Shape Controller (ASC) and Convergence Mode (CM) in Eclipse (Varian Medical System) in terms of plan quality and complexity of volumetric modulated arc therapy (VMAT).Materials and methods:Forty VMAT plans were re-optimised for the prostate, prostate + lymph nodes, breast and head & neck patients retrospectively, changing the ASC settings (off, moderate, very high) and CM settings (off, on and extended).Results:Using ‘on’ or ‘extended’ CM increased plan quality in terms of planning target volume homogeneity and low-dose spread to the organs at risk (OAR). ‘Extended’ CM increased the optimisation time 4·3-fold compared to ‘on’, and deteriorated the plan quality in several simple planning cases. ‘Moderate’ ASC decreased plan complexity with minor effect on plan quality compared to ‘off’, but ‘very high’ ASC had larger adverse dosimetric effects. However, the ASC decreased the plan complexity only if the CM was turned ‘on’.Findings:Using ‘on’ CM increases the plan quality but using ‘extended’ CM is not recommended. The ‘moderate’ ASC decreased complexity without significant adverse effects on plan quality, and even ‘very high’ ASC may be used when plan simplicity is prioritised. However, if CM is not used, the ASC should also be turned off.
The Geographical Spread of State Executions during the Irish Civil War, 1922–23
Authors: Kissane Bill 
Published: December 2020

AbstractThe state executions of 81 IRA men during the Irish civil war have long been a bitter, almost taboo subject in Irish society. This article provides a geographical perspective on these executions. While the origins of the policy can be traced to elite divisions, the geographical spread of the executions, especially in 1923, reflected the geography of the civil war, and the need to broadcast state power at the local level during its guerrilla phase. The article maps the geographical spread of the executions and analyzes their diffusion in terms of a number of general and Irish-specific theories of civil war violence. Because the civil war originated in elite differences over a treaty, and because the two sides of the conflict had been so personally close at the elite level, historians have tended to explain the executions in terms of elite psychology. Yet while the initial development of the policy reflected the centralization of power by the protreaty elite, in terms of timing, strategic rationale, and location territorial perspectives on civil war explain much more about their diffusion in 1923.
A Deep Learning Approach to Spatiotemporal Sea Surface Height Interpolation and Estimation of Deep Currents in Geostrophic Ocean Turbulence
Authors: Manucharyan Georgy E. , Siegelman Lia , Klein Patrice 
Published: December 2020

AbstractSatellite altimeters provide global observations of sea surface height (SSH) and present a unique data set for advancing our theoretical understanding of upper‐ocean dynamics and monitoring its variability. Considering that mesoscale SSH patterns can evolve on timescales comparable to or shorter than satellite return periods, it is challenging to accurately reconstruct the continuous SSH evolution as currently available altimetry observations are still spatially and temporally sparse. Here we explore the possibility of SSH interpolation via Deep Learning by using synthetic observations from an idealized quasigeostrophic model of baroclinic ocean turbulence. We demonstrate that Convolutional Neural Networks with Residual Learning are superior in SSH reconstruction to linear and recently developed dynamical interpolation techniques. Also, the deep neural networks can provide a skillful state estimate of unobserved deep ocean currents at mesoscales. These conspicuous results suggest that SSH patterns of eddies might contain substantial information about the underlying deep ocean currents that are necessary for SSH prediction. Our training data are focused on highly idealized physics and diversification of processes needs to be considered to more accurately represent the real ocean. In addition, methodological improvements such as transfer learning and implementation of dynamically aware loss functions might be necessary to consider before its ultimate use with real satellite observations. Nonetheless, by providing a proof of concept based on synthetic data, our results point to deep learning as a viable alternative to existing interpolation and, more generally, state estimation methods for satellite observations of eddying currents.