bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bio-adsorption of Basic blue dye from aqueous solution onto raw and modified waste ash as economical alternative bio-adsorbent
Authors: Alene Adugna Nigatu , Abate Gietu Yirga , Habte Adere Tarekegne 
Published: February 2020

Abstract
Background : Dyes are one of the most hazardous material in industrial effluents which can cause several health problems in bio-life. The removal of dye from colored effluents has been attracted increasing attention in the recent decay. In this study raw, beneficiated and activated waste ash was evaluated as an adsorbent for removal of methylene blue (MB) from aqueous solution by batch adsorption method. Comprehensive characterization studies were carried out on each bio-adsorbents such as proximate analyses, bulk density, specific surface area, point of zero charge, pH and Fourier-Transform Infrared (FTIR) spectroscopy (which shows functional groups on adsorbents surface). Results : The effects of pH, adsorbent dosage, initial dye concentration, and contact time were determined in order to know the optimum condition and adsorption potential of the adsorbents. The methylene blue (MB) removal efficiency of raw, beneficiated and activated bio-adsorbents from aqueous solutions was recorded to be 95.212%, 89.172%, and 84.504%, respectively. It is reported that adsorption efficiency of MB on each adsorbents was quite different due to electrostatic and dispersion interaction between the dye molecules and the surface property of the adsorbents. The obtained results were well fitted with Freundlich isotherm model and adsorption process follows the pseudo second order kinetics model for both adsorbents. Conclusions : In fact the results showed that raw, beneficiated and activated waste ash bio-adsorbents could be employed as effective and economical alternative material in the near future use. Key words : Bio-adsorption, waste ash, adsorption capacity, surface modification, basic blue dye.
Studying Students' Knowledge of the Benefits, Challenges, and Applications of Big Data Analytics In Healthcare
Authors: Nazari Elham , Khodabandeh Maryam Edalati , Dadashi Ali , Rasoulian Marjan , tabesh hamed 
Published: February 2020

Abstract
Introdution Today, with the advent of technologies and the production of huge amounts of data, Big Data analytics has received much attention especially in healthcare. Understanding this field and recognizing its benefits, applications and challenges provide useful background for conducting efficient research. Therefore, the purpose of this study was to evaluate the students' familiarity from different universities of Mashhad with the benefits, applications and challenges of Big Data analysis.Method This is a cross-sectional study that was conducted on students of Medical Engineering, Medical Informatics, Medical Records and Health Information Management in Mashhad-Iran. A questionnaire was designed based on literature review in pubmed, google scholar, science direct and EMBASE databases, using Delphi method and presence of 10 experts from different fields of study. The designed questionnaire evaluated the opinion of students regarding benefits, challenges and applications of Big Data analytics. 200 students participated in the study and completed the designed questionnaire. Participants' opinions were evaluated descriptively and analytically. Result Most students were between 20 and 30 years old. 63% of them were male and 43.5% had no work experience. Current and previous field of study of most of the students were HIT, HIM, and Medical Records. Most of the participants in this study were undergraduates. 61.5% were economically active, 54.5% were exposed to Big Data. The mean scores of participants in benefits, applications, and challenges section were 3.71, 3.68, and 3.71, respectively, and process management was significant in different age groups (p=0.046), information, modeling, research, and health informatics across different fields of studies were significant (p=0.015, 0.033, 0.001, 0.024) Information and research were significantly different between groups (p=0.043 and 0.019), research in groups with / without economic activity was significant (p= 0.017) and information in exposure / non exposure to Big Data groups was significant (p=0.02). Conclusion Despite the importance and benefits of Big Data analytics, students' lack of familiarity with the necessity and importance of these analytics in industries and research is significant. The field of study and level of study do not appear to have an effect on the degree of knowledge of individuals regarding Big Data analysis. The design of technical training courses in this field may increase the level of knowledge of individuals regarding Big Data analysis.
Evaluation for Photosynthetic Characteristics in upland cotton germplasm based on chlorophyll a fluorescence
Authors: sun ying , Xu Xiaoming , Dong Wenqing , Du Xiongming , Jia Yinhua , Tang Canming 
Published: February 2020

Abstract
Background: The research of photosynthetic characteristics of germplasm resources of cotton ( Gossypium hirsutum L.) provides reference for genetic improvement on cotton cultivars. Chlorophyll a fluorescence (CF) is widely used for analysis of photosynthetic activity of plants leaves. However, large number of Chlorophyll a fluorescence parameters (CFPs) and inconsistency CFPs application in different studies confuse researchers, which greatly limit the accuracy of photosynthesis analysis. In this study, all 53 CFPs of 189 upland cotton cultivars (strains) measured by handy PEA were screened at 12:00 and 17:00 separately. Results: 9 CFPs including PI(abs), DIo/CSo, PI(abs, total), Sm/T, Vj, Eto/CSo, REo/CSo, RC/CSo and N at 12:00 and 8 CFPs including PI(abs, total), PI(abs), DIo/CSo, Sm/T, REo/CSo, N, Vj and Eto/CSo at 17:00 are suitable for screening of upland cotton cultivars (strains). The screened CFPs classify and evaluate the photosynthetic characteristics of upland cotton cultivars (strains). Conclusions: CFPs selected can be effect and consistent parameters to evaluate photosynthetic activity of cotton germplasm.
Can red cell distribution width and hemoglobin level variations be utilized to predict the prognosis of Stage III operative colorectal cancer patients with adjuvant chemotherapy treatment?
Authors: Li Jie , Rui Yuan-Yi , Song Bo , Zhang Ke , Yi Bo , Zhou Ying , Zheng Yang-Chun 
Published: February 2020

Abstract
Background: The aim of this study was to find that if the red cell distribution width (RDW) or hemoglobin (Hb) level variations had prognostic value in stage III colorectal cancer patients treated with operation and adjuvant chemotherapy.
Methods: One hundred and twenty-two patients were included in this retrospective study. All were diagnosed and re-staged as stage III colorectal cancer in Sichuan Cancer Hospital according to the AJCC Cancer Staging Manual, 8 th edition, 2018. The patients received R0 resection before adjuvant chemotherapy. The baseline information, routine blood examination data, pathological outcome and prognostic stature was retracted from the database. Receiver operating characteristic (ROC) curve analysis was utilized to determine the cut-off value, while the survival analyses were performed with Kaplan-Meier curve, the log-rank test and the Cox regression analysis.
Results: The chemotherapy-associated hemoglobin change (change between the pre- and post-chemotherapy hemoglobin levels) was identified to be associated with the metastasis (P=0.030). The optimal cut-off point was calculated to be -9.5 by the ROC curve of the hemoglobin change, while the area under the curve was 0.648 (95% CI: 0.524-0.772). The results showed that patients with larger hemoglobin decrease had significantly worse disease free survival (DFS) than those with smaller decrease (P=0.020). Factors associated with DFS in uni-variate COX regression analysis were the number of harvested lymph nodes (P=0.040) and the perineural invasion (P=0.020). The peri-chemotherapy change of hemoglobin level was estimated to have significant effect on patient survival (P=0.010).
Conclusions: We concluded that chemotherapy-associated Hb change (change between the pre- and post-chemotherapy) was a DFS prognostic factor for the stage III colorectal cancer patients who underwent operation and adjuvant chemotherapy.
Hepatocellular carcinoma with right atrial tumor thrombus: a meta-analysis
Authors: Yuan Shi-Min , Guo Yi-Xian 
Published: February 2020

Abstract
Background: Hepatocellular carcinoma with right atrial tumor thrombus is uncommon but with a dismal prognosis.
Methods: By comprehensive retrieval of the pertinent literature published since 2000, 53 reports were collected with 187 patients recruited into this study. The quantitative data were expressed in mean±standard deviation with range and median values and were compared by independent samples t -test. The categorical variables were compared by Chi-square or Fisher exact test with continuity correction.
Results: The survival rate of patients receiving transarterial chemoembolization was 33.3% and that of surgical patients was 41.9%. The survival time of patients with transarterial chemoembolization treatment was longer than that of surgical patients, but lack of a statistical significance.
Conclusions: Even though advanced hepatocellular carcinoma with right atrial thrombus is an aggressive malignancy, the the present study showed that patient prognoses were improved and survival time was elongated with the advances of active treatments such as transarterial chemoembolization and surgical treatments. Active treatments are advised to patients with hepatocellular carcinoma with right atrial tumor thrombus in order to improve patients’ survival.
Evaluation of primary care services in Hungary
Authors: Rurik Imre , Jancsó Zoltán , Kalabay László , Lánczi Levente , Mester Lajos , Móczár Csaba , Nánási Anna , Semanova Csilla , Schmidt Péter , Szidor Judit , Tamás Hajnalka , Torzsa Peter , Ungvári Tímea , Végh Mária , Vraukó Katalin , Kolozsvári László 
Published: February 2020

Abstract
Background. It is a major challenge to show what configurations of primary care(PC) is associated with better outcomes, in terms of quality, equity and costs. The QUALICOPC Study tried to analyse and compare them within 35 countries, using validated questionnaires filled by family physicians/general practitioners (GPs). This paper aims to provide data of the Hungarian-arm of the QUALICOPC Study; to compare some findings to that of other participating countries; to give a comprehensive overview about the recent Hungarian PC system. Methods. Altogether 222 questionnaires were completed by Hungarian GPs, delivered by fieldworkers, in a geographically representative distribution. Results . Financing are based mostly on capitation, with smaller additional compensatory elements and minor quality incentives. The gate-keeping function is weak, although by referrals, the preference of patients is mostly considered. Communication between PC and specialists is often insufficient. Variety of available devices and equipment’s are appropriate. Single handed practices were 87%. Appointment instead of queuing is a new option and become more popular, mainly among better educated and urban patients. GPs are involved in the management of almost all chronic condition of all generations. Half of them estimate their job as still interesting, burn-out symptoms were rarely found. Among the evaluated process indicators, access, continuity, comprehensiveness and coordination were rated as satisfactory, together with equity among health outcome indicators. Financing is not sufficient, therefore many GPs are involved in other earning activities. The increasing shortage of manpower is a major challenge. Conclusions. In the past 2 decades, there was visible improvement at service level and in economic circumstances. Cooperation and communication between different levels of health care provision should be improved, focusing better to community orientation and to preventive services. There is a need for specific primary care oriented guidelines to define the expected tasks of GPs.
Molecular Mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens
Authors: França Laise Carolina , Fontes-Dantas Fabrícia Lima , Garcia Diogo Gomes , Araújo Amanda Dutra de , Gonçalves João Paulo da Costa , Rêgo Cláudia Cecília da Silva , Silva Elielson Veloso da , Nascimento Osvaldo José Moreira do , Lopes Fernanda Cristina Rueda , Herlinger Alice Laschuk , Aguiar Renato Santana de , Junior Orlando da Costa Ferreira , Figueira Fernando Faria Andrade , Souza Jorge Paes Barreto Marcondes de , Mesquita Joelma Freire De , Alves-Leon Soniza Vieira Vieira 
Published: February 2020

Abstract
Background: Evidences indicate a strong link between Zika virus (ZikV) and neurological complications. Acute myelitis, optic neuritis, polyneuropathy and encephalomyelitis that mimic inflammatory idiopathic demyelination disorders (IIDD) after ZikV infection have been reported in Brazil. In that context, the present study aims to investigate the possible occurrence of molecular mimicry between ZikV antigens and Multiple Sclerosis (MS) autoantigens, the most frequent IIDD of the central nervous system (CNS). Methods: A retrospective cohort study with 305 patients admitted due to suspected arbovirus infection in Rio de Janeiro was performed, all subjects were submitted to neurological examination and biological sample was collected for serologic and molecular diagnostic. Bioinformatics tools were used to analyze the peptides shared between ZikV antigens and MS autoantigens. Results: Of 305 patients, twenty-six were positive for ZikV and 4 presented IDD pattern found in MS cases. Sequence homology comparisons by bioinformatics approach between NS5 ZikV (most common strains) and PLP MS protein revealed a homology of 5/6 consecutive amino acids (CSSVPV/CSAVPV) with 83% identity, deducing a molecular mimicry. In addition, analysis of the 3D structures of both proteins revealed a similar conformation with alpha helix presentation. Conclusions: Molecular mimicry between NS5 Zika virus antigen and PLP MS autoantigens emerge as a possible mechanism for IDD spectrum in genetically susceptible individuals.
Association between Peer Education and HIV Testing Among Student MSM in China: A Cross-Sectional Study
Authors: Li Changping , Wang Xiaomeng , Cui Zhuang , Yu Zeyang , Zhang Honglu , Huang Huijie , Wang Chun , Zhang Tiantian , Yao Tingting , Chen Yang , Song Desheng , Yang Jie , Liu Yuanyuan , Ma Jun 
Published: February 2020

Abstract
Background

HIV prevalence among young men who have sex with men (YMSM) (<25 years old) all over the world varied dramatically from 35.5%(Gambia) to 0.5%(Belgium). In China, by contrast, the HIV prevalence among YMSM was at a low level (5.6%). However, the number of newly diagnosed college students has increased by 30 to 50 percent annually and HIV prevalence among student MSM in China has increased over the past few years, with access to HIV testing and peer education remaining limited. The objective of this study was to examine the relationship between peer education and HIV testing among student MSM in China.

Methods

The cross-sectional study was conducted in Tianjin, China between January 1, 2018 and December 31,2018. 494 student MSM aged 17-24years old were recruited using snowball sampling. Outcome variables were tested and not tested for HIV in the past year. Besides, social demographics, and sex-related behaviors were collected.

Results

The prevalence of HIV infection for the population was 5% (25/494). Overall, 60.5% of student MSM had tested for HIV in the past year, among which 68.9% had received peer education service. Peer education was significantly associated with HIV testing. After adjusting for sociodemographic characteristics, sexual behaviors, knowledge about HIV and STD infection, student MSM who received peer education were more likely to test for HIV [OR=19.751; 95%CI: (8.630,45.202)].

Conclusions

HIV testing coverage among student MSM in China remains suboptimal. Peer education is significantly associated with HIV testing among this population. Government and non-government organizations could consider this alternatively risk-reduction prevention strategy in the future.
Timely detection of Pertussis outbreaks in Iran: The comparison performance of Wavelet-based outbreak detector, Exponential weighted moving average, and Poisson regression-based methods
Authors: Alimohamadi Yousef , Zahraei Seyed Mohsen , Karami Manoochehr , Yaseri Mehdi , Lotfizad Mojtaba , Holakouie-Naieni Kourosh 
Published: February 2020

Abstract
Background Early detection of outbreaks is very important for surveillance systems. Due to the importance of the subject and lack of similar studies in Iran, the aim of this study was to determine the performance of the Wavelet-Based Outbreak detection method)WOD(in detecting outbreaks and to compare its performance with Poisson regression-based model and Exponential weighted moving average (EWMA) using data of simulated pertussis outbreaks in Iran. Methods The data on suspected cases of pertussis from 25th February 2012 to 23rd March 2018 in Iran was used. The performance of the WOD (Daubechies 10 and Haar wavelets), Poisson regression-based method, and EWMA Compared in terms of timeliness and detection of outbreak days using the simulation of different outbreaks (literature-based and researcher-made outbreaks). The sensitivity, specificity, false alarm and false negative rate, positive and negative likelihood ratios, under ROC areas and median timeliness were used to assess the performance of the methods. Results In a literature-based outbreak simulation, the highest and lowest sensitivity, false negative in the detection of injected outbreaks were seen in Daubechies 10 (db10), with sensitivity 0.59 (0.56-0.62), and Haar wavelets with 0.57 (0.54-0.60). In the researcher-made outbreaks, the EWMA (K=0.5) with sensitivity 0.92 (0.90-0.94) had the best performance. About timeliness, the WOD methods showed the best performance in the early warning of the outbreak in both simulation approaches. Conclusions Performance of the WOD in the early alarming outbreaks was appropriate. However, it's better as the method was used along with other methods in public health surveillance systems.
Serosurvey of anti-Toxoplasma gondii and anti-HIV antibodies in homeless persons of southeastern Brazil
Authors: Felipetto Laís Giuliani , Teider-Junior Pedro Irineu , Silva Felipe Fortino Verdan da , Yamakawa Ana Carolina , Kmetiuk Louise Bach , Couto Anahi Chechia do , Martins Camila Marinelli , Vaz Eduarda Stankiwich , Ullmann Leila Sabrina , Langoni Helio , Timenetsky Jorge , Santos Andrea Pires dos , Biondo Alexander Weilker 
Published: February 2020

Abstract
Background: Homeless persons have been described as one of the most vulnerable populations worldwide, with higher morbidity and mortality of diseases associated with HIV occurrence. Seroprevalence of Toxoplasma gondii and HIV has been extensively studied in other vulnerable populations, however, no study to date have focused on their concomitant seroprevalence in homeless persons. Accordingly, the present study aimed to assess the concomitant seroprevalence of anti-T. gondii and anti-HIV antibodies and associated risk factors in homeless persons in a daytime homeless shelter of São Paulo, southeastern Brazil. Methods: Anti-T. gondii antibodies were detected by indirect fluorescent antibody test and anti-HIV levels by chemiluminescence enzyme immunoassay, with positive samples confirmed by rapid immunoblot assay. Results: Overall, IgG anti-T. gondii seropositivity was found in 43/120 (35.8%) homeless persons, with endpoint titers varying from 16 to 1,024. The only two pregnant women tested were negative for IgM by chemiluminescence enzyme immunoassay, with normal parturition and clinically healthy newborns in both cases. There were no statistical differences in the risk factors for anti-T. gondii serology (p>0.05). Anti- HIV seropositivity was found in 2/120 (1.7%) homeless persons, confirmed as HIV-1. One HIV seropositive individual was also sero-reactive to IgG anti-T. gondii, and both were negative to IgM anti-T. gondii. One HIV positive person was also diagnosed with syphilis, tuberculosis and body lice presence, while the other never returned for assistance. No evaluation of anti- HIV risk factors has been made due to the low seropositive rate. Conclusions: The anti-T. gondii prevalence herein was lower than other Brazilian populations, likely related to predominant intake of processed food such as ready-to-eat and fast-food meals, and thus, low ingestion of fresh salad and raw meat. On the other hand, the anti- HIV seropositivity was higher than the average of the general Brazilian population, with 0.4%. Despite the low prevalence of anti-T. gondii in homeless persons, clinical manifestations may be aggravated in HIV positive individuals. To the author's knowledge, this is the first study of anti-T. gondii serosurvey in homeless persons concomitantly assessed with anti-HIV seropositivity.
Laboratory Findings on a Patient with Strongyloies Stercoralis Pulmonary Infection after Long Term Steroid Hormone and Immunosuppressive Treatment
Authors: Zhao Hongying , Deng Shuang , Liang Yuanzi , Qin Zhiqiang , Liang Li , Geradts Joseph , Huang Huayi 
Published: February 2020

Abstract
Background: Strongyloies stercoralis infection is common in tropical and humid areas worldwide. However, strongyloidiasis caused by Strongyloies stercoralis infection is often neglected in clinic. We report a misdiagnosed case of Strongyloies stercoralis infected female patient who had been admitted to four different hospitals for treatment, she eventually died upon Strongyloies stercoralis hyperinfection with pulmonary infection involved.Case presentation: A Strongyloies stercoralis infected woman was misdiagnosed as community acquired pneumonia, connective tissue disease and Sjogren's syndrome, and treated by mistake.She eventually died upon Strongyloies stercoralis hyperinfection with pulmonary infection involved. The patient’s clinical presentations, imaging results of the lungs, numerous Strongyloies Stercoralis larvae and eggs found in the stool, increased eosenophil count in peripheral blood, and elevated serological IgE level were evidences of Strongyloies stercoralis hyperinfection.Conclusion: The patient was infected with Strongyloies Stercoralis and died from the hyperinfection after long term use of immunosuppressive agents.