bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRODUÇÃO DE DOCUMENTÁRIO SOCIOAMBIENTAL: CONTRIBUIÇÕES NA FORMAÇÃO DISCENTE DO CURSO TÉCNICO EM CONTROLE AMBIENTAL
Authors: Nunes Silva Barbara Aparecida , Rocha Marcelo Borges 
Published: September 2020

Essa pesquisa tem por objetivo investigar a contribuição do processo de produção de documentário socioambiental na formação de estudantes do Curso Técnico em Controle Ambiental. A Educação Profissional e Tecnológica Integrada tem o trabalho como princípio educativo e o currículo integrado como concepção de ensino-aprendizagem fundamentado na formação humana integral. No currículo integrado, a contextualização do ensino proporciona a integração dos saberes. Nesse sentido, o desenvolvimento colaborativo de mídia educacional envolvendo uma temática socioambiental pode contribuir para proporcionar a construção do saber de forma lúdica e criativa. Dessa forma, a pesquisa articulou a produção colaborativa de documentário com a Educação Profissional e Tecnológica Integrada. A pesquisa é do tipo participante e se apoia em Le Boterf (1984) para a configuração do quadro metodológico. Desenvolveu-se oficinas no processo de produção do documentário com um grupo de alunos voluntários do Curso Técnico em Controle Ambiental e analisou-se os resultados conforme fundamentação teórica, onde se observa a superação da visão fragmentada de meio ambiente e compreensão holística da temática socioambiental identificada.
A Conceptual Analysis of Solid Self-emulsifying Drug Delivery System and its Associate Patents for the Treatment of Cancer
Authors: Singh Neeraj , Rai Shweta , Bhattacharya Sankha 
Published: September 2020

Background:
About two-third of new drugs reveal low solubility in water due to which it
becomes difficult for formulation scientists to develop oral solid dosage forms with a pharmaceutically
acceptable range of therapeutic activity. In such cases, S-SMEEDS are the best carriers used universally
for the delivery of hydrophobic drugs. SEDDS are also used but due to their limitations, SSMEDDS
are used widely. These are the isotropic mixtures of oils, co-solvents, and surfactants. SSMEDDS
are physically stable, easy to manufacture, easy to fill in gelatin capsules as well as improve
the drug bioavailability by releasing the drug in the emulsion form into the gastrointestinal tract and
enable smooth absorption of the drug through the intestinal lymphatic pathway.

Methods:
We conducted a literature search related to our review, also employing the peer-reviewed research,
and provided a conceptual framework. Standard tools were used for drawing the figures of the
paper, and various search engines were used for literature exploration. In this review article, the author
has discussed the importance of S-SMEDDS, selection criteria for excipients, pseudo-ternary diagram,
mechanism of action of S-SMEDDS, solidification techniques used for S-SMEDDS, Characterization
of SEDDS and S-SMEDDS including Stability Evaluation of both and future prospects have been concluded
through recent findings on S-SMEDDS in Cancer as well as a neoteric patent on S-SMEDDS.

Results:
Many research papers have been discussed in this review article, from which it was found that
the ternary phase diagram is the most crucial part for developing the SMEDDS. From the various research
findings, it was found that the excipient selection is the essential step which decides the strong
therapeutic effect of the formulation. The significant outcome related to solid-SMEDDS is the less the
globule size, the higher would be the bioavailability. The method in which adsorption of a solid carrier
takes place is most widely used for the preparation of solid-SMEDDS. After reviewing many patents, it
was observed that the solid-SMEDDS have a strong potential for targeting and treating different types
of cancer due to their properties to enhance permeation and increase bioavailability.

Conclusion:
S-SMEEDS are more acceptable pharmaceutically as compared to SEDDS due to their
various advantages over SEDDS, such as stability issue is prevalent with SEDDS. A number of patent
researchers have formulated S-SMEDDS of poorly soluble drugs and found S-SMEDDS as prospective
for the delivery of hydrophobic drugs in the treatment of cancer. S-SMEEDS are increasingly grabbing
attention, and the patentability on S-SMEDDS is unavoidable, which proves that S-SMEEDS are
widely accepted carriers. These are used universally for the delivery of hydrophilic drugs and anticancer
drugs as they release the drug to the gastrointestinal tract and enhance the systemic absorption.
PEMBELAJARAN BERBASIS MASALAH EKOWISATA PADA MATA PELAJARAN EKONOMI SMA
Authors: Baroroh Kiromim 
Published: September 2020

Abstrak: Penulisan kajian ini mempunyai tujuan: 1) mengidentifikasi permasalahan ekowisata, 2) mengetahui Model Pengembangan Ekowisata Berkelanjutan, dan 3) Mengetahui tahap pembelajaran berbasis masalah dalam pembelajaran ekonomi. Kajian literatur ini menggunakan metode narrative review dan descriptive review. Hasil dari kajian ini adalah: 1) permasalahan ekowisata yaitu: a) pelanggaran konservasi, b) Rendahnya partisipasi masyarakat dalam Ekowisata, c) Pengelolaan yang salah, d) Kurang pelibatan lembaga pendidikan formal di sekitar sekolah; 2) Model pengembangan ekowisata berkelanjutan yang disusun berdasarkan: a) visi dan tujuan utama pola pengembangan serta pengelolaan wisata adalah pembangunan berkelanjutan; b) Elemen Produk Pariwisata berbentuk wisata yang berbasis masyarakat, c) Memiliki pilar pelestarian lingkungan, pendidikan berbasis partisipasi, pengayaan atraksi, pelestarian budaya, keeratan masyarakat, dan pemberdayaan ekonomi masyarakat lokal d) mendapat dukungan penuh oleh seluruh pemangku kepentingan; 3) pembelajaran berbasis masalah dalam pembelajaran ekonomi di kelas meliputi tahap: a) merumuskan masalah ekowisata, b) menelaah masalah ekowisata, c) merumuskan hipotesis ekowisata, d) mengumpulkan data tentang ekowisata e) membuktikan hipotesis, f) Menentukan pilihan penyelesaian masalah ekowisata. Ekowisata dapat menjadi sumber belajar peserta didik secara langsung maupun tidak langsung.Abstract: The writing of this study aims: 1) to identify the problem of ecotourism, 2) to know the Model of Sustainable Ecotourism Development, and 3) To identify the stage of problem-based learning in economic learning. This research is a literature review using a narrative review and descriptive review methods. The results of this study are: 1) ecotourism issues, namely: a) conservation violations, b) low community participation in ecotourism, c) mismanagement, d) lack of involvement of formal educational institutions around schools; 2) Sustainable Ecotourism Development Model based on four elements, namely; a) Making the issue of Sustainable Development the central vision and objective of the pattern of tourism development and management; b) In the form of community-based tourism as an Element of Tourism Products, c) Having pillars of environmental preservation, cultural preservation, enrichment of attractions, participation-based education, community closeness, and economic empowerment of local communities as Criteria Element, d) Fully supported by all stakeholders; 3) problem-based learning in economic learning in class includes the stages: a) Formulating the problem of ecotourism, b) Analyzing the problem of ecotourism, c) Formulating a hypothesis of ecotourism, d) Collecting data of ecotourism, e) Proving the hypothesis, f) Determining the choice of resolution . Ecotourism can be a source of student learning, both directly and indirectly.
The Design of a Randomized Clinical Trial to Evaluate a Pragmatic and Scalable eHealth Intervention for the Management of Gestational Weight Gain in Low-Income Women: Protocol for the SmartMoms in WIC Trial
Authors: Flanagan Emily W , Altazan Abby D , Comardelle Natalie R , Gilmore L Anne , Apolzan John W , St. Romain Jessica , Hardee Julie C , Puyau Renee S , Mayet Christy L , Beyl Robbie A , Barlow S Ariel , Bounds Sarah Surber , Olson Kelsey N , Kennedy Betty M , Hsia Daniel S , Redman Leanne M 
Published: September 2020

Background
Less than one-third of women gain an appropriate amount of weight during pregnancy, which can influence the long-term health of both the mother and the child. Economically disadvantaged women are the most vulnerable to maternal obesity, excessive weight gain during pregnancy, and poor birth outcomes. Effective and scalable health care strategies to promote healthy weight gain during pregnancy specifically tailored for these women are lacking.

Objective
This paper presents the design and protocol of a biphasic, community-based eHealth trial, SmartMoms in WIC, to increase the adherence to healthy gestational weight gain (GWG) recommendations in low-income mothers receiving women, infant, and children (WIC) benefits.

Methods
Phase 1 of the trial included using feedback from WIC mothers and staff and participants from 2 community peer advisory groups to adapt an existing eHealth gestational weight management intervention to meet the needs of women receiving WIC benefits. The health curriculum, the format of delivery, and incentive strategies were adapted to be culturally relevant and at an appropriate level of health literacy. Phase 2 included a pragmatic randomized controlled trial across the 9 health care regions in Louisiana with the goal of enrolling 432 women. The SmartMoms in WIC intervention is an intensive 24-week behavioral intervention, which includes nutrition education and exercise strategies, and provides the technology to assist with weight management, delivered through a professionally produced website application.

Results
Phase 1 of this trial was completed in July 2019, and recruitment for phase 2 began immediately thereafter. All data are anticipated to be collected by Spring 2023.

Conclusions
The SmartMoms in WIC curriculum was methodically developed using feedback from community-based peer advisory groups to create a culturally relevant, mobile behavioral intervention for mothers receiving WIC benefits. The randomized clinical trial is underway to test the effectiveness of a sustainable eHealth program on the incidence rates of appropriate GWG. SmartMoms in WIC may be able to offer an innovative, cost-effective, and scalable solution for GWG management in women served by WIC.

Trial Registration
ClinicalTrials.gov NCT04028843; https://clinicaltrials.gov/ct2/show/NCT04028843

International Registered Report Identifier (IRRID)
DERR1-10.2196/18211
Topics, Delivery Modes, and Social-Epistemological Dimensions of Web-Based Information for Patients Undergoing Renal Transplant and Living Donors During the COVID-19 Pandemic: Content Analysis
Authors: van Klaveren Charlotte W , de Jong Peter G M , Hendriks Renée A , Luk Franka , de Vries Aiko P J , van der Boog Paul J M , Reinders Marlies E J 
Published: September 2020

Background
The COVID-19 pandemic has markedly affected renal transplant care. During this time of social distancing, limited in-person visits, and uncertainty, patients and donors are relying more than ever on telemedicine and web-based information. Several factors can influence patients’ understanding of web-based information, such as delivery modes (instruction, interaction, and assessment) and social-epistemological dimensions (choices in interactive knowledge building).

Objective
The aim of this study was to systemically evaluate the content, delivery modes, and social-epistemological dimensions of web-based information on COVID-19 and renal transplantation at time of the pandemic.

Methods
Multiple keyword combinations were used to retrieve websites on COVID-19 and renal transplantation using the search engines Google.com and Google.nl. From 14 different websites, 30 webpages were examined to determine their organizational sources, topics, delivery modes, and social-epistemological dimensions.

Results
The variety of topics and delivery modes was limited. A total of 13 different delivery modes were encountered, of which 8 (62%) were instructional and 5 (38%) were interactional; no assessment delivery modes were observed. No website offered all available delivery modes. The majority of delivery modes (8/13, 62%) focused on individual and passive learning, whereas group learning and active construction of knowledge were rarely encountered.

Conclusions
By taking interactive knowledge transfer into account, the educational quality of eHealth for transplant care could increase, especially in times of crisis when rapid knowledge transfer is needed.
Strategi Pengembangan Wisata Bersepeda Berdasarkan Karakteristik Motivasi Pesepeda Urban (Pada Grup Sepeda TOC Dan JGC-SCAM)
Authors: Laksmana Tb Adinda , Rachmat Heryadi , Tahir Rusdin 
Published: September 2020

Olahraga bagi sebagian orang sudah bukan hanya merupakan kebutuhan hidup sehari-hari, namun juga sudah dianggap sebagai gaya hidup. Dengan melakukan olah raga bukan hanya sekedar mendapatkan kebugaran tubuh tapi juga mendapatkan banyak manfaat lainnya. Trend Olah raga ini juga menjadi gaya hidup yang berkembang pesat pada masyarakat urban, dengan semakin banyaknya kelompok masyarakat tersebut yang rutin melakukan jenis olah raga yang dapat dilakukan di sela sela keterbatasan waktunya. Olah raga bersepeda adalah salah satu kegiatan yang banyak diminati oleh kaum urban. Munculnya kelompok bersepeda pada masyarakat urban merupakan refleksi dari kebutuhan berolah raga sambil berekreasi di luar ruangan. Terdapat berbagai macam motivasi para pesepeda, dari hanya sekedar berkeinginan berolah raga, berwisata, mengurangi efek polusi udara, penghematan bahan bakar dan menghindari kemacetan, mencari pengalaman dan tantangan baru, pertemanan, hingga hanya sekedar mencari aktualisasi diri. Untuk mengetahui jenis motivasi beraktifitas bersepeda pada masyarakat urban, dilakukan kuesioner terhadap kelompok bersepeda serta penggemar kegiatan bersepeda lainnya. Hasil kuesioner yang diperoleh dapat mengelompokan serta mencirikan para pesepeda kaum urban berdasarkan karakteristik dan motivasi, serta menentukan strategi strategi pengembangan wisata pesepeda kaum urban dengan menganalisa faktor faktor internal IFAS dan eksternal EFAS dari karakteristik motivasi para pesepeda urban tersebut, serta menentukan strategi berdasarkan metode SWOT. Sehinga diperoleh strategi strategi pengembangan wisata bersepeda bagi masyarakat urban.
ASSESSMENT OF DRUG UTILIZATION AMONG PEDIATRIC PATIENTS IN PRIVATE CLINIC AND PUBLIC HOSPITAL OF BANGLADESH
Authors: UDDIN AHSAN , PAUL TRIPTI RANI , MONWAR MONALISA , SARKER SHAHIN , SULTANA CHAND , WAHED MIR IMAM IBNE 
Published: September 2020

Objective: Aim of the study was to assess drug utilization among pediatric patients in both private practice and hospital settings in Rajshahi city, Bangladesh.
Methods: This observational study was conducted during a period of two months (March to April) in 2017. Prescriptions were randomly collected from patients and recorded in a predesigned questionnaire form. The data analysis was carried out by using a statistical software package GraphPad Prism.
Results: The study involved a total of 185 patients, of which 62.70% were male and 37.30% were female. The patient’s age ranges from 1 mo-12 y and highest number of patients visited physicians belong to group 1 mo-1 y (47.57%). Most commonly occurring disease conditions were pneumonia (24%), the leading cause of hospitalizations among the children's age group of 1 mo-1 y. The results indicated that physician’s handwriting was not clear and legible in 50 (27.03%) prescriptions. A total of 468 drugs were prescribed with an average of 2.53 per prescription. However, none of the drugs were prescribed by generic name. The most commonly prescribed drugs were antibiotics 173 (93.5%). About 78% patients were exposed to antibiotics, of which single antibiotic was prescribed in 116 (62.70%) and two antibiotics in 23 (12.43%) prescriptions. Among the drugs, NSAIDS 65 (35.14%), anti-histamine 57 (30.81%), anti-asthmatic 49 (26.49%) drugs were assigned in prescriptions followed by vitamin and minerals 51 (27.57%). Steroids 57 (30.81%) and hypnotics 26 (14.05%) were also accounted in many prescriptions. Interestingly, antibiotics were indiscriminately prescribed in private practices without any bacteriological examinations, whereas in hospital settings, most of the treatment was initiated after culture and sensitivity tests.
Conclusion: Children were highly exposed to antibiotics, steroids and hypnotics in both private practice and hospital settings. So Medical practitioners should be aware of current guidelines for prescriptions of antibiotics and drugs in child.
FACTORS ASSOCIATED WITH QUALITY OF LIFE AMONG PEOPLE LIVING WITH HIV/AIDS ON HIGHLY ACTIVE ANTI RETROVIRAL THERAPY: A CROSS-SECTIONAL STUDY
Authors: SURYANA KETUT , SUHARSONO HAMONG , JOENPUTRI NOVIANA 
Published: September 2020

Objective: To assess Quality of life (QoL) and its associated factors in people living with HIV/AIDS (PLWHA) who taking highly active antiretroviral therapy (HAART) in Wangaya Hospital in Denpasar, Bali, Indonesia.
Methods: A cross-sectional study was conducted during February 2019 to January 2020 at Wangaya Hospital in Denpasar, Bali, Indonesia. QoL was assessed using the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L), EQ-5D index value, and the EuroQol visual analogue scale (EQ-VAS). The data was analyzed using Statistical Package for Social Science (SPSS) software package version 26.0. Bivariate analysis was tested using the cross-tabulation Gamma, Kruskal-Wallis and post hoc Mann-Whitney test. P value<0.05 was considered as statistically significant.
Results: A total of 584 PLWHA took HAART for at least 3 mo. The median index value and EQ-VAS were 1.0 (range-0.514–1.0) and 100.00 (range 30-100), respectively. Most patients had problems in ‘anxiety/depression’ and ‘pain/discomfort’ domains. Predictors of better QoL included men, married, good adherence, and treatment duration>24 mo (p<0.05). Predictor of poorer QoL included an advanced HIV clinical stage(p=0.001).
Conclusion: The QoL scores of PLWHA receiving HAART in our study were high; hence the QoL of PLWHA was good. The good QoL can be taken as the goal for HIV treatment in order to have a successful HAART therapy.
COMPARATIVE STUDY BETWEEN PERIOSTIN AND OSTEOCALCIN AS BIOMARKERS FOR OSTEOPOROSIS AND FRACTURE RISK IN EGYPTIAN POSTMENOPAUSAL WOMEN
Authors: MOHAMED ALAA SALAM , KHALIFA ASHRAF ISMAIL , ABOTALEB ASHRAF ABDEL-MONEAM , ELDESOKY NOHA ABDEL-RAHMAN 
Published: September 2020

Objective: This study aimed to compare between periostin and osteocalcin as biomarkers in Egyptian postmenopausal women with osteoporosis and to explore their possible relationship with fracture risk.
Methods: This study included 90 postmenopausal females recruited from Al-Hussein University Hospital, Cairo, Egypt; divided into three groups; 35 postmenopausal osteoporotic females with low fracture risk (group I), 35 postmenopausal osteoporotic females with high fracture risk (group II), and 20 apparently healthy controls. Serum periostin, osteocalcin, and estrogen were measured by Enzyme Linked Immunosorbent Assay (ELISA). Fracture risk assessment was calculated. Alkaline phosphatase (ALP), total and ionized calcium, Aspartate transaminase (AST), and Alanine transaminase (ALT) were measured spectrophotometrically.
Results: The diagnostic performance of periostin for discriminating high fracture risk from low fracture risk groups showed the specificity of (68.6 %) and sensitivity of (100 %), while for osteocalcin the specificity was (51.4 %) and the sensitivity was (68.6 %) respectively. Moreover, the multi Receiver Operating Characteristics (multi-ROC) curve for periostin and osteocalcin together revealed improved specificity and sensitivity of (100 %) each.
Conclusion: Periostin was superior to osteocalcin in discriminating high fracture risk from low fracture risk postmenopausal osteoporotic groups. Moreover, dual use of both markers gave the highest discriminative power between low and high fracture risk groups with 100 % specificity and sensitivity.
Determination of Criteria and Drought Tolerance of Prope-Legitimate Cocoa Seed Through Polyethylene Glycol Induction
Authors: Zasari Maera , Susuilo Agung Wahyu , Wachjar Ade , Sudarsono Sudarsono 
Published: September 2020

The availability of drought tolerant rootstock becomes one of solution to obtain tolerant cocoa clone at drought condition. The production of rootstock is easier and faster by using prope-legitimate seeds as plant materials. Seed germination selection phase can accelerate the obtainment of tolerant cocoa rootstocks. The tolerance trait of prope-legitimate seeds can be determined by seed germination on media induced by polyethylene glycol (PEG) solution. To determine the tolerant seeds, it is effective by using a specific character as selection criteria. This study aimed to obtain criteria and selection character to determine droughttolerant characteristic of prope-legitimate seed through PEG 6000 induction in the germination phase. The research was conducted at the Agronomy Laboratoryof the Indonesian Coffee and Cocoa Research Institute, Jember, East Java, Indonesia, used split plot design with five replications as experimental design. The main plot was solution of 0% and 6% PEG 6000, while the subplot were prope-legitimate seeds of 13 cocoa clones. The result showed that germination ability and sprout fresh weight were suitable as selection criteria to determine tolerant characteristic of prope-legitimate seeds to drought stress. Based on the value of tress susceptible index and clustering analysis, the tested prope-legitimate seeds were divided into three groups. The group of tolerant genotype consisted of Sca 06, while the group of medium tolerant were ICCRI 03, Sulawesi 02, KW 641, TSH 858, KEE 02, Sulawesi 03, and KW 617. The susceptible group consisted of six genotypes, namely ICS 60, KKM 22, KW 516, Sulawesi 01, and MCC 02.
Administração, OMS e Covid-19: uma Relação Conflitiva
Authors: Santos Reginaldo Souza , Silva Emerson de Sousa , Ribeiro Elizabeth Matos , Santos Elinaldo Leal Santos , Martins Carolina Chagas 
Published: September 2020

Este texto é resultado de um trabalho de natureza exploratória que visa analisar os aspectos administrativos que estão sendo empregados para a interpretação e resolução dos impactos causados pela pandemia da Covid-19. Para cumprir esse objetivo, a discussão proposta se fundamentou nas bases teórico-metodológicas da administração política, considerando-a ser um campo de conhecimento mais apropriado para interpretar os fatos e atos que dão expressão e sentido às relações sociais, particularmente as produção e distribuição. Como base empírica, o estudo foi estruturado para realizar uma discussão sustentada em uma ‘trilogia’, considerando três dimensões geoespaciais de análise principais: a OMS, objeto deste primeiro ensaio; o comportamento dos países desenvolvidos, com destaque para os EUA, alguns países europeus, China e Japão; e concluindo com a análise das singularidades brasileiras. Como resultado desse primeiro exercício sobre a concepção do padrão de administração assumido pela OMS, foi possível concluir que os acertos e erros na gestão da Pandemia da Covid-19, em âmbito global, são definidores dos sucessos e fracassos dos processos de intervenções que têm por finalidade última solucionar ou ao menos mitigar os problemas sociais. Nesse sentido, considera-se que o retardo das ações por parte da OMS, especialmente no que se refere à decisão declaratória da situação de emergência elevou enormemente os custos para as nações e para a economia global.