bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffusion‐Weighted MRI Predicts Lymph Node Metastasis and Tumor Aggressiveness in Resectable Pancreatic Neuroendocrine Tumors
Authors: Harimoto Norifumi , Araki Kenichiro , Hoshino Kouki , Muranushi Ryo , Hagiwara Kei , Ishii Norihiro , Tsukagoshi Mariko , Igarashi Takamichi , Watanabe Akira , Kubo Norio , Tomonaga Hiroyasu , Higuchi Tetsuya , Tsushima Yoshito , Ikota Hayato , Shirabe Ken 
Published: August 2020

AbstractObjectivesThe aim of this study was to identify whether diffusion‐weighted magnetic resonance imaging (DW‐MRI) can predict the malignant behavior of preoperative well‐differentiated pancreatic neuroendocrine tumors (PanNETs).MethodForty patients with PanNETs who underwent pancreatectomy were enrolled in this study. The apparent diffusion coefficient (ADC) values were measured. Clinicopathological factors were compared in patients with high ADC and low ADC values and in patients with and without lymph node metastasis (LNM).ResultThe low ADC group was significantly associated with higher Ki‐67 index, higher mitotic count, larger tumor size, higher rate of LNM, and venous invasion. In patients with low ADC values, the incidence of LNMs was 33.3%. In patients with high ADC values, there were no patients with LNM being 0%. A significant negative correlation was found between the mean ADC values and the Ki‐67 index and between the mean ADC values and the mitotic count. In multivariate analysis, neural invasion and mean ADC values ≤ 1458 were independent predictors of LNM.ConclusionADC values obtained using DW‐MRI in the preoperative assessment of patients with PanNETs might be a useful predictor of malignant potential, especially LNM.
A survey of modeling, rendering and animation of clouds in computer graphics
Authors: Goswami Prashant 
Published: August 2020

AbstractClouds play an important role in enhancing the realism of outdoor scenes in computer graphics (CG). Realistic cloud generation is a challenging task, which entails processes such as modeling, photorealistic rendering and simulation of the clouds. To these ends, several techniques have been proposed within the CG community in the last 4 decades with one or more of the above stated focuses. The growth of modern hardware has also enabled development of techniques that can achieve cloud display and animation at interactive frame rates. In this survey, we review the prominent work in the domain and also summarize the evolution of the research over the time.
Surgical debridement of infected pubic symphysitis supports optimal outcome
Authors: Devlieger Benjamin , Wagner Daniel , Hopf Johannes , Rommens Pol Maria 
Published: August 2020

AbstractIntroductionInfected pubic symphysitis (IPS) is a rare bacterial infection of the pubic symphysis that causes subpubic pain, disability and ultimately permanent immobility. Due to difficult diagnosis, patients present with long-standing complaints and consult several doctors. To date, no validated treatment protocol exists and most patients are treated conservatively with antibiotics. This study was aimed to assess the results after careful surgical debridement and pathogen-specific antibiotic treatment in IPS.Materials and methodsA chart review of eight patients with proven IPS was performed. Five of eight patients filled in a specific own-developed questionnaire and could be examined clinically and radiologically at a mean of 13 months (range: 6–30 months) postoperatively.ResultsThere were six males and two females with an average age of 69 years (range: 55–80 years). The mean duration of symptoms before surgical treatment was 10.5 months (range: 1–30 months). There were no complications due to the surgical debridement. There was no recurrence of infection at the pubic symphysis during the follow-up period. The most common pathogen wasPseudomonas aeruginosain three patients. Mean preoperative pain, measured on the visual analogue scale (VAS, range: 0–10) for the four analysed categories in the five follow-up patients was 7.2, 30 days postoperatively 2.7 and 13 months postoperatively 0.4. There was a steady increase in the quality of life (QoL) 30 days postoperatively and at the 13 months follow-up when compared to preoperative values.ConclusionsSurgical debridement is the keystone for treatment of IPS and should be combined with local and systemic antibiotic therapy.
Individual variability of olfactory fMRI in normosmia and olfactory dysfunction
Authors: Yunpeng Zang , Han Pengfei , Joshi Akshita , Hummel Thomas 
Published: August 2020

Abstract
Purpose
The diagnosis of olfactory dysfunction is mainly based on psychophysical measurements. The aim of the current study was to investigate how well the olfactory functional magnetic resonance imaging (fMRI) can effectively distinguish between normosmic people and subjects with olfactory dysfunction.

Methods
Thirty-eight participants were recruited for the study. Group 1 consisted of 22 subjects with olfactory dysfunction (mean age = 44.3 years, SD = 18.6), and Group two consisted of 16 participants with normal olfactory function (mean age = 49.6 years, SD = 11.6). Olfactory functions were assessed in great detail for all participants, and brain activation in response to odorous stimulation was assessed using fMRI.

Results
The between-group comparison showed stronger odor induced brain activation of the primary olfactory area and the insular cortex among the normosmic group as compared to the dysosmic group. As indicated by the individual analysis, positive responses in the primary olfactory cortex were significantly higher in normosmic people (94%) than in subjects with olfactory dysfunction (41%). However, there was no association between individual fMRI parameters (including the percentage of BOLD signal change, activated cluster size and peak z value), and psychophysical olfactory test scores. Receiver operating characteristic analysis suggested the subjects could not be differentiated from normosmics based on their BOLD signal from the primary olfactory area, orbitofrontal cortex, or the insular cortex.

Conclusion
There are large inter-individual variabilities for odor-induced brain activation among normosmic subjects and subjects with olfactory dysfunction, due to this variation, at present it appears problematic to diagnose olfactory dysfunction on an individual level using fMRI.
Acute binocular diplopia: peripheral or central?
Authors: Kremmyda Olympia , Frenzel Claudia , Hüfner Katharina , Goldschagg Nicolina , Brem Christian , Linn Jennifer , Strupp Michael 
Published: August 2020

Abstract
Objectives
Acute diplopia is a diagnostic challenge for clinicians, in particular in the emergency department. The most common cause of acute diplopia are ocular motor nerve palsies (OMP). In this prospective study, we focused on identifying the most crucial signs and symptoms for differentiating between peripheral and central OMP.

Methods
We prospectively evaluated 56 non-consecutive patients who presented at our emergency department with acute binocular diplopia (≤ 10 days). The patient history was taken using a standardized questionnaire and patients underwent a neurological, neuro-ophthalmological and neuro-otological examination, including measurement of the subjective visual vertical (SVV), Harms tangent screen test, and cranial MRI.

Results
Forty-six out of 56 patients were diagnosed with an ocular motor cranial nerve palsy (OMP), 21 of peripheral and 23 of central origin; in two patients, the etiology remained unknown. The following features were different in peripheral and central OMP: (1) the presence of vertigo/dizziness was more frequent in central (43.5%) than in peripheral (9.5%) OMP. (2) Central ocular motor signs, such as saccadic smooth pursuit, additional internuclear ophthalmoplegia, skew deviation, and saccade palsies, were also found more frequently in the central than in the peripheral group (86.7% vs. 33.3%). (3) Further, a pathological SVV deviation by monocular testing of the non-affected eye was also more common in central (77.3%) than in peripheral OMP (38.9%). The presence of all three factors has a positive predictive value of 100% (CI 50–100%) for the presence of a central lesion.

Conclusions
In acute diplopia due to central OMP, the most important accompanying symptom is vertigo/dizziness, and the most important clinical signs are central ocular motor disorders (which require examination of the non-paretic eye) and an SVV deviation in the non-paretic eye.
Review of preventative HIV vaccine clinical
trials in South Africa
Authors: Laher Fatima , Bekker Linda-Gail , Garrett Nigel , Lazarus Erica M. , Gray Glenda E. 
Published: August 2020

AbstractNew HIV infections continue relentlessly in southern Africa, demonstrating
the need for a vaccine to prevent HIV subtype C. In South Africa, the country with the
highest number of new infections annually, HIV vaccine research has been ongoing since
2003 with collaborative public-private-philanthropic partnerships. So far, 21 clinical
trials have been conducted in South Africa, investigating seven viral vectors, three DNA
plasmids, four envelope proteins, five adjuvants and three monoclonal antibodies. Active
vaccine candidates have spanned subtypes A, B, C, E and multi-subtype mosaic sequences.
All were well tolerated. Four concepts were investigated for efficacy: rAd5-gag/pol/nef
showed increased HIV acquisition in males, subtype C ALVAC/gp120/MF59 showed no
preventative efficacy, and the trials for the VRC01 monoclonal antibody and
Ad26.Mos4.HIV/subtype C gp140/ aluminum phosphate are ongoing. Future trials are planned
with DNA/viral vector plus protein combinations in concert with pre-exposure
prophylaxis, and sequential immunization studies with transmitted/founder HIV envelope
to induce broadly neutralizing antibodies. Finally, passive immunization trials are
underway to build on the experience with VRC01, including single and combination
antibody trials with an antibody derived from a subtype-C-infected South African donor.
Future consideration should be given to the evaluation of novel strategies, for example,
inactivated-whole-virus vaccines.
Management of post-traumatic craniovertebral junction dislocation: A PRISMA-compliant systematic review and meta-analysis of casereports
Authors: Klepinowski Tomasz , Limanówka Bartosz , Sagan Leszek 
Published: August 2020

AbstractAlthough historically considered fatal, with the advent of improved pre-hospital care, traumatic dislocation of the craniovertebral junction (CVJ) has been increasing in prevalence in neurosurgical centers. As more survivors are reported each year, a timely review with meta-analysis of their management seems necessary. PRISMA checklist was followed step by step. PubMed and Web of Science databases were searched using words “craniovertebral junction dislocation” and their corresponding synonyms. Study eligibility criteria included research studies from 2015 onwards that delineated adult and pediatric patients with confirmed post-traumatic atlantooccipital dislocation (AOD) or atlantoaxial dislocation (AAD) who survived until proper treatment. Of 1475 initial records, 46 articles met eligibility criteria with a total of 141 patients with traumatic CVJ dislocation. Of the patients, 90 were male (63.8%). Mean age of the cohort was 33.3 years (range 1–99 years). Trauma that most often led to this injury was road traffic accident (70.9%) followed by falls (24.6%). The majority of authors support posterior instrumentation of C1-C2 (45.2%) especially by means of Goel-Harms method. At mean follow-up of 15.4 months (range 0.5–60 months), 27.2% of treated patients remained neurologically intact. Of initially symptomatic, 59% improved, 37% were stable, and 4% deteriorated. Instrumenting the occiput in cases of pure AAD was associated with lower chance of neurological improvement in chi-square test (p = 0.0013) as well as in multiple linear regression (β = − 0.3; p = 0.023). The Goel-Harms C1-C2 fusion is currently the most frequently employed treatment. Many survivors remain with no deficits or improve, rarely deteriorate. Involving the occiput in stabilization in cases of AAD without AOD might be related with worse neurological prognosis.
Group Theoretical Derivation of Consistent Free Particle Theories
Authors: Nisticò Giuseppe 
Published: August 2020

AbstractThe difficulties of relativistic particle theories formulated by means of canonical quantization, such as those of Klein–Gordon and Dirac, ultimately led theoretical physicists to turn to quantum field theory to model elementary particle physics. In order to overcome these difficulties, the theories of the present approach are developed deductively from the physical principles that specify the system, without making use of canonical quantization. For a free particle these starting assumptions are invariance of the theory and covariance of position with respect to Poincaré transformations. In pursuing the approach, the effectiveness of group theoretical methods is exploited. The coherent development of our program has shown that robust classes of representations of the Poincaré group, discarded by the known particle theories, can in fact be taken as bases for perfectly consistent theories. For massive spin zero particles, six inequivalent theories have been determined, two of which do not correspond to any of the current ones; all of these theories overcome the difficulties of Klein–Gordon one. The present lack of the explicit transformation properties of position with respect to boosts prevents the complete determination of non zero spin particle theories. In the past a particular form of these transformation properties was adopted by Jordan and Mukunda. We check its consistency within the present approach and find that for spin $$\frac{1}{2}$$

1
2

particles there is only one consistent theory, which is unitarily related to Dirac’s; yet, once again, it requires classes of irreducible representations previously discarded.
An adaptive large neighborhood search heuristic for the planar storage location assignment problem: application to stowage planning for Roll-on Roll-off ships
Authors: Hansen Jone R. , Fagerholt Kjetil , Stålhane Magnus , Rakke Jørgen G. 
Published: August 2020

AbstractThis paper considers a generalized version of the planar storage location problem arising in the stowage planning for Roll-on/Roll-off ships. A ship is set to sail along a predefined voyage where given cargoes are to be transported between different port pairs along the voyage. We aim at determining the optimal stowage plan for the vehicles stored on a deck of the ship so that the time spent moving vehicles to enable loading or unloading of other vehicles (shifting), is minimized. We propose a novel mixed integer programming model for the problem, considering both the stowage and shifting aspect of the problem. An adaptive large neighborhood search (ALNS) heuristic with several new destroy and repair operators is developed. We further show how the shifting cost can be effectively evaluated using Dijkstra’s algorithm by transforming the stowage plan into a network graph. The computational results show that the ALNS heuristic provides high quality solutions to realistic test instances.
Rheum rhaponticum and Rheum rhabarbarum: a review of phytochemistry, biological activities and therapeutic potential
Authors: Kolodziejczyk-Czepas Joanna , Liudvytska Oleksandra 
Published: August 2020

AbstractThe Rheum genus (Polygonaceae) covers about 60 species of rhubarbs, including specimens with a long ethnomedicinal history in Asia, Europe and other regions of the world. The work reviews available literature (until March, 2020) on phytochemical profile, ethnomedicinal recommendations, biological activities, pharmacological uses and future prospects for therapeutic applications of Rheum rhabarbarum L. (garden rhubarb) and Rheum rhaponticum L. (rhapontic rhubarb). Although the above species are well-known vegetables, scientific interest in these plants is a relatively new issue; most of evidence of their biological activities and therapeutic potential derives from the last 15 years. Rhubarbs contain numerous bioactive substances, belonging to diverse groups of phytochemicals, e.g. stilbenes, anthraquinones and flavonoids. The registered special extract of R. rhaponticum (ERr731®) is administered to alleviate the menopause-related complaints. Furthermore, both ethnomedicinal surveys and recent studies on bioactive substances from rhubarbs indicate that these plants may have significantly broader range of beneficial effects such as antioxidant, anti-inflammatory, antimicrobial and cardioprotective activities.
Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group
Authors: Olsen Alexander , Babikian Talin , Bigler Erin D. , Caeyenberghs Karen , Conde Virginia , Dams-O’Connor Kristen , Dobryakova Ekaterina , Genova Helen , Grafman Jordan , Håberg Asta K. , Heggland Ingrid , Hellstrøm Torgeir , Hodges Cooper B. , Irimia Andrei , Jha Ruchira M. , Johnson Paula K. , Koliatsos Vassilis E. , Levin Harvey , Li Lucia M. , Lindsey Hannah M. , Livny Abigail , Løvstad Marianne , Medaglia John , Menon David K. , Mondello Stefania , Monti Martin M. , Newcombe Virginia F.J. , Petroni Agustin , Ponsford Jennie , Sharp David , Spitz Gershon , Westlye Lars T. , Thompson Paul M. , Dennis Emily L. , Tate David F. , Wilde Elisabeth A. , Hillary Frank G. 
Published: August 2020

AbstractThe global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group’s short-term, intermediate, and long-term goals.
Hybrid compliance compensation for path accuracy enhancement in robot machining
Authors: Hähn Felix , Weigold Matthias 
Published: August 2020

AbstractRobot machining processes with high material removal rates lack of high path accuracy mainly due to the low stiffness of industrial robots. The low stiffness leads to process forces caused deviations of the tool center point (TCP) from the planned position of more than 1 mm in industrial applications. To enhance the path accuracy a novel hybrid compliance compensation is developed. It combines a force sensor and model based online compensation with forces of an offline simulation to instantly react to predictable high force changes e.g. at a milling cutter exit from the work piece. The method is applied to a KUKA KR 300 robot. A compliance model based on a forward kinematic with virtual joints is implemented on an external controller. Cartesian or axis specific compensation values are calculated and transferred to the robot via a control circuit. A compliance measurement method is developed and a force torque sensor is mounted to the flange of the robot. The system is validated in with Cartesian and axis specific compensation values as well as with and without pilot control.
Smooth estimation of size distributions in an oriented cylinder model
Authors: Jongbloed Geurt , McGarrity Kimberly S. , Sietsma Jilt 
Published: August 2020

AbstractKernel estimators are proposed for estimating the cumulative distribution functions and the probability density functions of several quantities of interest in a stereological oriented cylinder model. This oriented cylinder model was developed to represent anisotropic microstructural features in materials. The asymptotic properties of these estimators are studied, and the estimators are applied to two banded dual phase steel microstructures. The estimation method is quite general and can also be applied to distributions of other univariate quantities of interest.
Clinical characteristics and treatment of delirium in palliative care settings
Authors: Portela Millinger Filipe , Fellinger Matthäus 
Published: August 2020

SummaryDelirium is commonly seen in palliative care. It usually develops over a short period of time and is characterized by a disturbance of attention and awareness. As delirium is associated with increased mortality, prevention and early identification of this severe neurocognitive disorder is of high clinical relevance. This paper provides a brief overview of risk factors, preventive measures, current screening and diagnostic procedures, as well as nonpharmacological and pharmacological treatment options of delirium in the palliative care setting.
Enabling trade across borders and food security in Africa
Authors: Bonuedi Isaac , Kamasa Kofi , Opoku Eric Evans Osei 
Published: August 2020

AbstractWidespread food insecurity remains a daunting challenge in Africa, despite significant gains in global efforts to eliminate hunger over the last three decades. This paper examines the effects of easing trade across borders – through reductions in documents, time, and costs to export and import – on food security outcomes in Africa. To control for endogeneity, this paper employs the first-difference instrumental variable estimator based on panel data covering 45 African countries over the period 2006–2015. The results reveal that poor trade facilitation constitutes a significant driver of food insecurity in Africa. In particular, ineffective trade facilitation is associated with significant increments in the prevalence of undernourishment and depth of food deficit, as well as reductions in dietary energy supply adequacy and access to sanitation facilities. The results show that food availability and food access are significantly hampered by higher documentation requirements and lengthier export and import times. The results suggest that reductions in delays from documentary and border compliance promise to be the most effective trade facilitation reforms to enhance food security in Africa.
Water quality assessment using NSFWQI, OIP and multivariate techniques of Ganga River system, Uttarakhand, India
Authors: Matta Gagan , Nayak Anjali , Kumar Avinash , Kumar Pawan 
Published: August 2020

AbstractGanga River water is very much stressed with the rapidly increasing population, climate change and water pollution that increase domestic, agricultural and industrial needs. This study assesses the surface water quality of the River Ganga in India, using NSFWQI, OIP and multivariate techniques. During the current study, water samples from Ganga River were collected for the assessment of 19 physico-chemical determinants from 20 sampling locations. Water quality indices (WQIs) is used to classify the overall impact of different variables of water. Multivariate techniques were utilized to assess the water conditions for productive management of fresh water quality. The WQI results showed that surface water quality varied at the selected sampling sites among medium and good categories. The PCA generates the 6 principle components which highly contributes (80.3%) in influencing the hydro-chemistry of river water. Agricultural waste runoff, untreated effluents and many other anthropogenic activities were identified as main contributor in decreasing the water quality of the River Ganga. To maintain and protect this fresh water resources against contamination, the usage of stringent policies and rules are expected to preserve fresh water resources for people in the future.