bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Biosystems by Printing Biology
Authors: Arrabito Giuseppe , Ferrara Vittorio , Bonasera Aurelio , Pignataro Bruno 
Published: June 2020

AbstractThe continuous progress of printing technologies over the past 20 years has fueled the development of a plethora of applications in materials sciences, flexible electronics, and biotechnologies. More recently, printing methodologies have started up to explore the world of Artificial Biology, offering new paradigms in the direct assembly of Artificial Biosystems (small condensates, compartments, networks, tissues, and organs) by mimicking the result of the evolution of living systems and also by redesigning natural biological systems, taking inspiration from them. This recent progress is reported in terms of a new field here defined as Printing Biology, resulting from the intersection between the field of printing and the bottom up Synthetic Biology. Printing Biology explores new approaches for the reconfigurable assembly of designed life‐like or life‐inspired structures. This work presents this emerging field, highlighting its main features, i.e., printing methodologies (from 2D to 3D), molecular ink properties, deposition mechanisms, and finally the applications and future challenges. Printing Biology is expected to show a growing impact on the development of biotechnology and life‐inspired fabrication.
Ultrathin 2D Mesoporous TiO2/rGO Heterostructure for High‐Performance Lithium Storage
Authors: Liang Yaru , Xiong Xiang , Xu Zhuijun , Xia Qingbing , Wan Liyang , Liu Rutie , Chen Guoxin , Chou Shu‐Lei 
Published: June 2020

AbstractLithium‐ion batteries (LIBs) have been widely applied and studied as an effective energy supplement for a variety of electronic devices. Titanium dioxide (TiO2), with a high theoretical capacity (335 mAh g−1) and low volume expansion ratio upon lithiation, has been considered as one of the most promising anode materials for LIBs. However, the application of TiO2 is hindered by its low electrical conductivity and slow ionic diffusion rate. Herein, a 2D ultrathin mesoporous TiO2/reduced graphene (rGO) heterostructure is fabricated via a layer‐by‐layer assembly process. The synergistic effect of ultrathin mesoporous TiO2 and the rGO nanosheets significantly enhances the ionic diffusion and electron conductivity of the composite. The introduced 2D mesoporous heterostructure delivers a significantly improved capacity of 350 mAh g−1 at a current density of 200 mA g−1 and excellent cycling stability, with a capacity of 245 mAh g−1 maintained over 1000 cycles at a high current density of 1 A g−1. The in situ transmission electron microscopy analysis indicates that the volume of the as‐prepared 2D heterostructures changes slightly upon the insertion and extraction of Li+, thus contributing to the enhanced long‐cycle performance.
Urchin‐Like Fe3Se4 Hierarchitectures: A Novel Pseudocapacitive Sodium‐Ion Storage Anode with Prominent Rate and Cycling Properties
Authors: Zhang Jian , Liu Yongchang , Liu Hui , Song Yuzhu , Sun Shengdong , Li Qiang , Xing Xianran , Chen Jun 
Published: June 2020

AbstractTransition metal chalcogenides have received great attention as promising anode candidates for sodium‐ion batteries (SIBs). However, the undesirable cyclic life and inferior rate capability still restrict their practical applications. The design of micro–nano hierarchitectures is considered as a possible strategy to facilitate the electrochemical reaction kinetics and strengthen the electrode structure stability upon repeated Na+ insertion/extraction. Herein, urchin‐like Fe3Se4 hierarchitectures are successfully prepared and developed as a novel anode material for SIBs. Impressively, the as‐prepared urchin‐like Fe3Se4 can present an ultrahigh rate capacity of 200.2 mAh g‐1 at 30 A g‐1 and a prominent capacity retention of 99.9% over 1000 cycles at 1 A g‐1, meanwhile, a respectable initial coulombic efficiency of ≈100% is achieved. Through the conjunct study of in situ X‐ray diffraction, ex situ X‐ray absorption near‐edge structure spectroscopy, as well as cyclic voltammetry curves, it is intriguing to reveal that the phase transformation from monoclinic to amorphous structure accompanied by the pseudocapacitive Na+ storage behavior accounts for the superior electrochemical performance. When paired with the Na3V2(PO4)3 cathode materials, the assembled full cell enables high energy density and decent cyclic stability, demonstrating potential practical feasibility of the present urchin‐like Fe3Se4 anode.
Developing Industry 4.0 with systems perspectives
Authors: Hou Ting , Cheng Baihua , Wang Rongxiao , Xue Wei , Chaudhry Peggy E. 
Published: June 2020

AbstractThis paper analyses the definition and connotation of Industry 4.0 and proposes that intelligent manufacturing and innovative service are the two core elements of the Industry 4.0. The paper also discusses standardization, integrated information system, training and education, artificial intelligence applications, and the infrastructure issues for the development of Industry 4.0.
Light emitting fabrics for photodynamic therapy: Technology, experimental and clinical applications
Authors: Mordon Serge , Thécua Elise , Ziane Laurine , Lecomte Fabienne , Deleporte Pascal , Baert Grégory , Vignion‐Dewalle Anne‐Sophie 
Published: June 2020

AbstractA homogeneous and reproducible fluence rate delivery during clinical photodynamic therapy (PDT) plays a determinant role in preventing under‐ or overtreatment. The development of a flexible light source able to generate uniform light on all its surface would considerably improve the homogeneity of light delivery. The integration of plastic optical fibers into textile structures offers an interesting alternative. This article aims to describe briefly the technology used to develop light emitting fabrics (LEF) and their use in vitro (CELL‐LEF), in vivo (VIVO‐LEF) for experimental evaluation of PDT. Finally, the use of LEF for clinical applications is given by three examples. For in vitro applications, the CELL‐LEF device allows the illumination of several 96‐well cell culture plates. For the VIVO‐LEF, the system developed for PDT can treat three mice simultaneously with a homogeneous and high irradiance The medical LEF systems developed for PDT in dermatology for the treatment of actinic keratosis demonstrate their superiority thanks to a uniform light distribution due the flexibility of LEF. Interestingly, the technology used for manufacturing LEF is very well known by the textile industry, leading to very competitive production costs. The fact that optical fibers can transmit light from 400 to 1200 nm allows the connection of LEF to different laser sources covering the light spectrum of all photosensitizers used for medical applications. New developments should allow to use the LEF inside cavities such as the pleural or the peritoneal cavities.
Students' attitudes toward science and science achievement: An analysis of the differential effects of science instructional practices
Authors: Liou Pey‐Yan 
Published: June 2020

AbstractThe purpose of this study was to examine the predictive effects of inquiry‐based and teacher‐directed instructional practices on students' attitudes toward science and science achievement in a nationally representative sample of 7,708 15‐year‐old‐students from Taiwan who took part in the sixth cycle of the Program for International Student Assessment (PISA). The results of structural equation modeling analyses, after accounting for student demographic and socioeconomic characteristics, revealed that teacher‐directed instructional practices had a significant positive effect on students' science achievement, whereas inquiry‐based instructional practices had a significant negative effect on students' science achievement. Moreover, the results of the study indicated that inquiry‐based instructional practices had greater positive predictive power than teacher‐directed instructional practices for students' attitudes toward science. The inverse relations between inquiry‐based science instructional practices and student science achievement contradicts the popular belief that inquiry‐based science instructional practices help improve student science achievement. However, the results of the current study underscore the positive effects of inquiry‐based instructional practices on students' attitudes toward science. Indeed, optimizing the frequency of instructional practices in science classrooms to promote the desired educational outcomes deserves further discussion.
Microalgae‐based biodiesel production in open raceway ponds using coal thermal flue gas: A case of West Bengal, India
Authors: Bhadra Sitav , Salam P. Abdul , Sarker Nilay Kumar 
Published: June 2020

AbstractIndia is one of the most populous countries and is the third largest greenhouse gas–emitting nation. Energy security is a serious issue for India as it relies heavily on fossil fuel imports. Biodiesel production using microalgae as feedstock can address both of these issues. In this study, the technical feasibility of microalgae‐based biodiesel production is carried out for a coal thermal power plant (i.e., Budge Budge Thermal Station) in the state of West Bengal, India, using a generic methodology. An oleaginous microalgae species that is tolerant toward flue gas was identified (i.e., Nannochloropsis sp). A 75‐acre open raceway microalgae production plant was designed keeping the costs, energy demand, and CO2 emissions low. The open raceway pond can use 38 tons of CO2, produce 19 tons of algal biomass, and treat 9320 m3 of wastewater per acre annually.
Genomic analysis of porcine circovirus type 2 from southern China
Authors: Lv Qizhuang , Wang Tao , Deng Jiahua , Chen Yan , Yan Qiu , Wang Daobo , Zhu Yulin 
Published: June 2020

AbstractBackgroundPorcine circovirus type 2 (PCV2) is recognized as virulent porcine pathogen and has been linked to porcine circovirus diseases (PCVD). However, there remain many unknowns regarding the spread and epidemic growth of PCV2.MethodsTo assess the genetic diversity of PCV2 in the southern China, a total of 92 sequences of PCV2 strains from this region were retrieved from GenBank and were subjected to amino acid variation and phylogenetic analyses together with 28 representative sequences, based on the sequence of the ORF2 gene, from different swine‐producing countries.ResultsAll 92 PCV2 strains shared between 93.7% and 100% sequence similarity and could be divided into four genotypes (PCV2a, PCV2b, PCV2d and PCV2h), of which PCV2d had surpassed PCV2b and became the most prevalent PCV2 genotype in this region. Alignment of the deduced amino acid sequences of the capsid protein revealed that the obtained PCV2 strains possess two major heterogenic regions/hypervariable regions (positions 52–68 and 185–191), which were within or close to the epitopic regions in the capsid (Cap) protein. Meanwhile, the 92 PCV2 sequences also show evidence of at least five unique recombination events.ConclusionThe data in this study indicate that the PCV2 strains in the southern China are undergoing constant genetic variation and that the predominant strain and its antigenic epitopes in this area have been gradually changing in recent years.
Nesting biology of the Aplomado Falcon (Falco femoralis) at Parque Nacional das Emas, central Brazil
Authors: Tubelis Dárius Pukenis 
Published: June 2020

AbstractTe objective of this study was to investigate aspects of the nesting biology of the Aplomado Falcon,Falco femoralis(Temminck, 1822), at Parque Nacional das Emas, Brazil. Woodland (Campo Cerrado) frebreaks were searched for nests in October 2006 and October 2009 by driving a vehicle along a road adjacent to these fre managed vegetation strips. Most (62%) of the eight nests found were in canopies of fruitingPouteria tortatrees. Nests were at 2.2–3.8 m above ground. Invariably, clutch size was of three cream eggs and nestlings had a white plumage in the frst days of life. For two active nests, adults also defended an additional empty nest located in the surroundings. No evidences of nest destruction or predation were detected.Falco femoralissuccessfully uses frebreaks for breeding at Parque Nacional das Emas.
Fire management and aspects of the nesting biology of the Red-legged Seriema (Cariama cristata) in woodlands at Parque Nacional das Emas, central Cerrado
Authors: Tubelis Dárius Pukenis 
Published: June 2020

AbstractIn the Brazilian Cerrado Biome, fire management within conservation units is usually restricted to burning grassland and woodland strips during the dry season to stop fires from spreading. Although it is a common practice, the impact of fire management on birds remains poorly investigated. This study aimed to examine the effects of fire management on nest-site selection by the Red-legged Seriema,Cariama cristata, and to describe nest-building characteristics at Parque Nacional das Emas (PNE). Nests were searched and monitored throughout 34 study sites between October and November 2006. These sites were 2.5-km strips of Campo Cerrado woodlands with (firebreaks) and without fire management, located at the interior and boundaries of the park. A total of 13 nests were found, all within firebreaks at the edge of the park. Nine (69%) of them were in fruitingPouteria torta(Mart.) (Sapotaceae). Two or three white eggs were found in the nests. Nests had eggs and nestlings in October and no nestlings were found in November. Nests were usually in tree canopies and some of them were built nearly over the park’s fence. At PNE, breeding pairs ofC. cristataare attracted to firebreaks located at the park’s boundaries. This is probably due to mobility through often burnt vegetation and ease in obtaining food from adjacent unsealed roads, exotic plantations and cleared areas. This study suggests that fire managers should: 1) avoid extinguishing natural fires initiated during the rainy season and 2) rotate controlled burning of patchy areas of Campo Cerrado woodlands. These two procedures should ensure the presence of suitable woodlands with short grasses in interior portions of PNE.
Short-term movement patterns, population estimates and breeding biology of an island endemic bird, the Tristan Thrush
Authors: Ryan Peter G. , Dilley Ben J. , Davies Delia , Glass Trevor , Abadi Fitsum 
Published: June 2020

AbstractThe Tristan ThrushTurdus eremitais the only land bird that survived human colonisation of the main island of Tristan da Cunha and is listed as “Near Threatened”. Population estimates are confounded by the thrushes’ inquisitive and gregarious nature as well as limited information on their movements. We report the first measures of nest densities on Nightingale Island: 6 nests·ha-1inPhylica arboreawoodland and 4–5 nests·ha-1in tussock habitat, which suggests that the population is approximately double the previous estimate. At Inaccessible Island, we individually color ringed 110 thrushes over two months to track their short-term movements and estimate the local population size. Individuals moved up to 950 m along the coast, but 96% of resightings were < 100 m. A Bayesian data augmentation approach estimated that some 260 thrushes visited the core study area, a 200-m stretch of cobble and boulder beach where birds come to drink, bathe and forage. This result suggests that the population on Inaccessible Island also is substantially larger than reported previously. We estimate the total population to be 8000–15,000 Tristan Thrushes. The main need is a population estimate for the nominate subspecies on the main island of Tristan.
Major Climate Variability and Natural Factors in Boreal Winter
Authors: Roy Indrani 
Published: June 2020

AbstractThe role of natural factors, mainly solar 11-year cyclic variability and volcanic eruptions on two major modes of climate variability the North Atlantic Oscillation (NAO) and El Niño Southern Oscillation (ENSO) are studied for about the last 150 years period. The NAO is the primary factor to regulate Central England Temperature (CET) during winter throughout the period, though NAO is impacted differently by other factors in various time periods. Solar variability during 1978–1997 indicates a strong positive in-phase connection with NAO, which is different in the period prior to that. Such connections were further explored by known existing mechanisms. Solar NAO lagged relationship is also shown not unequivocally maintained but sensitive to the chosen times of reference. It thus points towards the previously known mechanism/relationship related to the Sun and NAO. This study discussed the important roles played by ENSO on global temperature; while ENSO is influenced strongly by solar variability and volcanic eruptions in certain periods. A strong negative association between the Sun and ENSO is observed before the 1950s, which is positive though statistically insignificant during the second half of the twentieth century. The period 1978–1997, when two strong eruptions coincided with active years of strong solar cycles, the ENSO and volcano suggested a stronger association. That period showed warming in the central tropical Pacific while cooling in the North Atlantic with reference to various other anomaly periods. It indicates that the mean atmospheric state is important for understanding the connection between solar variability, the NAO and ENSO and associated mechanisms. It presents critical analyses to improve knowledge about major modes of variability and their roles in climate and reconciles various contradictory findings. It discusses the importance of detecting solar signal which needs to be robust too.
Dynamical Belyi maps and arboreal Galois groups
Authors: Bouw Irene I. , Ejder Özlem , Karemaker Valentijn 
Published: June 2020

AbstractWe consider a large class of so-called dynamical Belyi maps and study the Galois groups of iterates of such maps. From the combinatorial invariants of the maps, we construct a useful presentation of the geometric Galois groups as subgroups of automorphism groups of regular trees, in terms of iterated wreath products. Using results on the reduction of dynamical Belyi maps modulo certain primes, we obtain results on the corresponding arithmetic Galois groups of iterates. These lead to results on the behavior of the arithmetic Galois groups under specialization, with applications to dynamical sequences.
ADRB3 expression in tumor cells is a poor prognostic factor and promotes proliferation in non-small cell lung carcinoma
Authors: Zheng Meng , Zhou Zhiling , Tian Xiangting , Xiao Dingzhang , Hou Xinghua , Xie Zhi , Liang Haidan , Lin Shuguang 
Published: June 2020

AbstractThe cross-talk between cancer cells and monocyte-derived alveolar macrophages (Mo-AMs) promotes non-small cell lung carcinoma (NSCLC) progression. In this study, we report that both cancer cells and Mo-AMs robustly express beta 3-adrenergic receptor (ADRB3) in NSCLC. ADRB3 supports lung cancer cells proliferation and promotes chronic inflammation. Genetic and pharmacologic inhibition of ADRB3 reverses tumor growth and inflammation in mouse. Furthermore, we demonstrate that M5D1, a novel anti-ADRB3 monoclonal antibody, inhibits human lung cancer cells proliferation and inflammation via affecting the intracellular mTOR pathway and activating p53. In NSCLC patients, we confirmed that upregulation of ADRB3 expression correlates with tumor progression and poor prognosis. Altogether, these results shed light on the role of ADRB3 in NSCLC and suggest that M5D1 could become powerful antitumor weapons.
Characterization of structures of particles
Authors: Manikas Konstantinos , Vogiatzis Georgios G. , Anderson Patrick D. , Hütter Markus 
Published: June 2020

AbstractA methodology for the characterization of particle structures, especially networks, is developed. This scheme combines 3D image analysis techniques with graph theory tools for the simplification of a structure of thick agglomerates to its skeleton. The connectivity graph of the initial structure is compared with the one of the corresponding skeleton, as a measure of simplification. Examples are used to illustrate the effectiveness of our scheme. Particle structures obtained by Brownian Dynamics simulations are characterized qualitatively and quantitatively. Instead of looking at the characteristics of the structure at the level of the individual particles or neighborhoods of particles, our scheme results in quantitative measures of the network, e.g. the number density of branch-points, the degree of branch-points, and the thickness and the orientation of the branches.
Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis
Authors: Ganapathi Mythily , Argyriou Loukas , Martínez-Azorín Francisco , Morlot Susanne , Yigit Gökhan , Lee Teresa M. , Auber Bernd , von Gise Alexander , Petrey Donald S. , Thiele Holger , Cyganek Lukas , Sabater-Molina María , Ahimaz Priyanka , Cabezas-Herrera Juan , Sorlí-García Moisés , Zibat Arne , Siegelin Markus D. , Burfeind Peter , Buchovecky Christie M. , Hasenfuss Gerd , Honig Barry , Li Yun , Iglesias Alejandro D. , Wollnik Bernd 
Published: June 2020

AbstractDilated cardiomyopathy (DCM) belongs to the most frequent forms of cardiomyopathy mainly characterized by cardiac dilatation and reduced systolic function. Although most cases of DCM are classified as sporadic, 20–30% of cases show a heritable pattern. Familial forms of DCM are genetically heterogeneous, and mutations in several genes have been identified that most commonly play a role in cytoskeleton and sarcomere-associated processes. Still, a large number of familial cases remain unsolved. Here, we report five individuals from three independent families who presented with severe dilated cardiomyopathy during the neonatal period. Using whole-exome sequencing (WES), we identified causative, compound heterozygous missense variants in RPL3L (ribosomal protein L3-like) in all the affected individuals. The identified variants co-segregated with the disease in each of the three families and were absent or very rare in the human population, in line with an autosomal recessive inheritance pattern. They are located within the conserved RPL3 domain of the protein and were classified as deleterious by several in silico prediction software applications. RPL3L is one of the four non-canonical riboprotein genes and it encodes the 60S ribosomal protein L3-like protein that is highly expressed only in cardiac and skeletal muscle. Three-dimensional homology modeling and in silico analysis of the affected residues in RPL3L indicate that the identified changes specifically alter the interaction of RPL3L with the RNA components of the 60S ribosomal subunit and thus destabilize its binding to the 60S subunit. In conclusion, we report that bi-allelic pathogenic variants in RPL3L are causative of an early-onset, severe neonatal form of dilated cardiomyopathy, and we show for the first time that cytoplasmic ribosomal proteins are involved in the pathogenesis of non-syndromic cardiomyopathies.