bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniform characterization of an ensemble of main-sequence benchmark stars: effect of Gaia-based data on grid search models
Authors: Nsamba Benard , Weiss Achim , Kamulali Juma 
Published: December 2024

ABSTRACT
The inference of stellar parameters (such as radius and mass) through asteroseismic forward modelling depends on the number, accuracy, and precision of seismic and atmospheric constraints. ESA’s Gaia space mission is providing precise parallaxes which yield an additional constraint to be included in the model grid search. Using a handful of main-sequence benchmark stars, we perform a uniform characterization of these stars. We assess the accuracy and precision of stellar parameters inferred from grid-based searches when a Gaia-based luminosity is combined with different stellar constraints. We also examine the precision needed for an interferometric radius (model-independent radius) to have a significant contribution towards the determination of stellar mass in the optimization process. Our findings show that more precise stellar masses are inferred for some stars when seismic and spectroscopic constraints are complemented with a Gaia-based luminosity, with a scatter varying from 1.9 per cent to 0.8 per cent. However, the inferred stellar radii are underestimated when compared to the interferometric radii and yield a scatter of $\sim$1.9 per cent. In addition, we demonstrate that a precisely measured interferometric radius ($\lesssim$1 per cent) when applied in the optimization process yields a mass with a precision $\lesssim$1.5 per cent. Finally, we find that when only $l=0$ mode oscillation frequencies are available, robust masses and radii are still attainable. However, this requires precise and numerous $l=0$ mode oscillations frequencies (&gt;8) to be coupled with atmospheric constraints.
The coupled tearing–thermal instability in coronal current sheets from the linear to the non-linear stage
Authors: De Jonghe Jordi , Sen Samrat 
Published: December 2024

ABSTRACT
In the solar corona, magnetically sheared structures are unstable to both tearing and thermal instabilities in a coupled fashion. However, how the choice of linear perturbation modes influences the time-scale to achieve the thermal runaway in a coupled tearing–thermal coronal current sheet is not well understood to date. Here, we model a force-free Harris current sheet under solar coronal conditions to investigate this coupling in the linear and non-linear regimes. In the linear regime, we adopt the magnetohydrodynamic spectroscopy code legolas to compare the current sheet under thermal and thermoresistive conditions, after which we initialize non-linear simulations (with mpi-amrvac) with the unstable, linear tearing and thermal perturbations obtained with legolas. It is shown that part of the unstable thermal quasi-continuum adopts tearing properties in the linear stage, but that it is not until the non-linear stage is reached that a true thermal ‘runaway’ effect leads to condensations inside tearing-induced flux ropes. Hence, the linear stage is governed by the dominant tearing instability whilst condensations form due to tearing–thermal coupling in the non-linear stage. Our results imply that perturbing an equilibrium current sheet with the fastest growing linear mode skips the mode-mixing phase in which the dominant instability traditionally emerges, and significantly reduces the time-scale to enter into the non-linear stage and thermal runaway process from its equilibrium configuration.
X-ray cavities in TNG-Cluster: AGN phenomena in the full cosmological context
Authors: Prunier Marine , Hlavacek-Larrondo Julie , Pillepich Annalisa , Lehle Katrin , Nelson Dylan 
Published: December 2024

ABSTRACT
Active galactic nuclei (AGNs) feedback from supermassive black holes (SMBHs) at the centres of galaxy clusters plays a key role in regulating star formation and shaping the intracluster medium, often manifesting through prominent X-ray cavities embedded in the cluster’s hot atmosphere. Here we show that X-ray cavities arise naturally due to AGN feedback in TNG-Cluster. This is a new suite of magnetohydrodynamic cosmological simulations of galaxy formation and evolution, and hence of galaxy clusters, whereby cold dark matter, baryon dynamics, galactic astrophysics, and magnetic fields are evolved together consistently. We construct mock Chandra X-ray observations of the central regions of the 352 simulated clusters at z = 0 and find that $\sim$39 per cent contain X-ray cavities. Identified X-ray cavities vary in configuration with some still attached to their SMBH, while others have buoyantly risen. Their size ranges from a few to several tens of kpc. TNG-Cluster X-ray cavities are underdense compared to the surrounding halo and filled with hot gas ($\sim 10^8$ K); 25 per cent of them are surrounded by an X-ray bright and compressed rim associated with a weak shock (Mach number $\sim$1.5). Clusters exhibiting X-ray cavities are preferentially strong or weak cool-cores, are dynamically relaxed, and host SMBHs accreting at low Eddington rates. We show that TNG-Cluster X-ray cavities originate from episodic, wind-like energy injections from central AGN. Our results illustrate the existence and diversity of X-ray cavities simulated in state-of-the-art models within realistic cosmological environments and show that these can form without necessarily invoking bipolar, collimated, or relativistic jets.
A lensed FRB candidate in the first CHIME/FRB Catalogue and its potential implications
Authors: Chang Chenming , Zhang Songbo , Xiao Di , Tang Zhenfan , Li Ye , Wei Junjie , Wu Xuefeng 
Published: December 2024

ABSTRACT
Fast radio bursts (FRBs) are immensely energetic radio pulses with durations of milliseconds. Given their high all-sky rate, the probability of an FRB being lensed by an intervening massive object is non-negligible. In this study, we search for possible lensing candidates within the first Canadian Hydrogen Intensity Mapping Experiment FRB catalogue using an autocorrelation algorithm and verification through signal simulations. We identify FRB 20190308C as a lensed candidate with a significance of 3.4$\sigma$. Furthermore, we constrain the mass of the lensing object using the Chang–Refsdal lens model, based on the flux ratio and time delay between the substructures of FRB 20190308C. Future long-term and high-precision observations are expected to reveal more lensed FRBs.
A pooled analysis of host factors that affect nucleotide excision repair in humans
Authors: Zheng Congying , Shaposhnikov Sergey , Collins Andrew , Brunborg Gunnar , Azqueta Amaya , Langie Sabine A S , Dusinska Maria , Slyskova Jana , Vodicka Pavel , van Schooten Frederik-Jan , Bonassi Stefano , Milic Mirta , Orlow Irene , Godschalk Roger 
Published: December 2024

Abstract
Nucleotide excision repair (NER) is crucial for repairing bulky lesions and crosslinks in DNA caused by exogenous and endogenous genotoxins. The number of studies that have considered DNA repair as a biomarker is limited, and therefore one of the primary objectives of the European COST Action hCOMET (CA15132) was to assemble and analyse a pooled database of studies with data on NER activity. The database comprised 738 individuals, gathered from 5 laboratories that ran population studies using the comet-based in vitro DNA repair assay. NER activity data in peripheral blood mononuclear cells were normalized and correlated with various host-related factors, including sex, age, body mass index (BMI), and smoking habits. This multifaceted analysis uncovered significantly higher NER activity in female participants compared to males (1.08 ± 0.74 vs. 0.92 ± 0.71; P = .002). Higher NER activity was seen in older subjects (&gt;30 years), and the effect of age was most pronounced in the oldest females, particularly those over 70 years (P = .001). Females with a normal BMI (&lt;25 kg/m2) exhibited the highest levels of NER, whereas the lowest NER was observed in overweight males (BMI ≥ 25 kg/m2). No independent effect of smoking was found. After stratification by sex and BMI, higher NER was observed in smoking males (P = .017). The biological implication of higher or lower repair capacity remains unclear; the inclusion of DNA repair as a biomarker in molecular epidemiological trials should elucidate the link between health and disease status.
Epidemiological and clinicopathological characteristics of vascular-limited renal AL amyloidosis
Authors: Senot Noémie , Gibier Jean Baptiste , Rabant Marion , Esteve Emmanuel , Ferriere Elsa , Dessaix Kathleen , Colombat Magali , Perrochia Helene , Olagne Jerome , Goujon Jean Michel , Wayolle Nicolas , Wemeau Mathieu , Carpentier Benjamin , Pinson Pierre , Beeker Nathanael , Bridoux Frank , Cohen Camille 
Published: December 2024

ABSTRACT

Background
Kidney involvement, along with cardiac disease, is the most frequent manifestation of systemic AL amyloidosis, usually resulting in nephrotic-range proteinuria. Rarely, deposits predominantly or exclusively affect the intrarenal arterioles or arteries, with these vascular-limited forms following a distinct clinical course, but very little is known about these forms. Our work planned to better characterize renal vascular-limited AL amyloidosis.

Methods
By mining a French Paris hospital database, we found that this unusual phenotype accounts for approximatively 9% of renal AL amyloidosis cases. We retrospectively studied 35 patients with the renal vascular-limited variant of AL amyloidosis on kidney biopsy.

Results
All showed predominant or only (n = 21) intra-renal vascular deposits, of lambda isotype in 63%. At diagnosis, median urine protein/creatinine ratio was 0.5 g/g, with serum creatinine of 181 (133–216) µmol/L and estimated glomerular filtration (eGFR) rate of 36.2 (24.3–49.6) mL/min/1.73 m2. Cardiac involvement was present in 67% of cases. A serum and/or urine monoclonal gammopathy was identified in all but one patient and 31 (88%) had an abnormal free light chain ratio. Among 28 treated patients, hematological and renal response rates were 75% (including deep hematological response in 43%) and 18%, respectively. Median time from diagnosis to renal event, defined be a composite criterion composed of end-stage renal disease or &gt;40% decrease in eGFR, was 56 months. Median overall survival was 59 months—significantly longer in patients who achieved a deep hematological response (178 vs 20 months, P = .002).

Conclusion
Renal vascular-limited AL amyloidosis is a probably underdiagnosed disease with markedly reduced eGFR, low-grade proteinuria and severe overall prognosis. Rapid achievement of a deep hematological response is required to preserve long-term renal and patient outcomes.
O-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner
Authors: Qiu Jiawei , Zhao Rongrong , Ma Caizhi , Wang Qingtong , Li Boyan , Qi Yanhua , Pan Ziwen , Zhao Shulin , Wang Shaobo , Gao Zijie , Guo Xiaofan , Qiu Wei , Tang Weijie , Guo Xing , Deng Lin , Xue Hao , Li Gang 
Published: December 2024

Abstract
Background: Interactions between mesenchymal glioblastoma stem cells (MES GSCs) and myeloid-derived macrophages (MDMs) shape the tumor-immunosuppressive microenvironment (TIME), promoting the progression of glioblastoma (GBM). N6-methyladenosine (m6A) plays important roles in the tumor progression. However, the mechanism of m6A in shaping the TIME of GBM remains elusive.
Methods: Single-cell RNA sequencing and bulk RNA-seq datasets were employed to identify the critical role of WTAP in interactions between MES GBM and MDMs. The biological function of WTAP was confirmed both in vitro and in vivo. Mechanistically, mass spectrum, RNA immunoprecipitation (RIP), and co-immunoprecipitation assays were conducted.
Results: Here, we identified that m6A methyltransferase Wilms' Tumor 1-Associated Protein (WTAP), whose protein stability could be synergistically enhanced via OGT-mediated O-GlcNAcylation and USP7-mediated de-ubiquitination, promoted LOXL2 m6A modification to enhance its mRNA stabilization in an IGF2BP2-dependent manner, upregulating secretion of LOXL2 protein (sLOXL2). sLOXL2 then interacted with integrin α5β1 on GSCs to activate FAK-ERK signaling, inducing mesenchymal transition of GSCs in an autocrine manner. Meanwhile, sLOXL2 also activated the integrin α5β1-FAK-ERK axis in MDMs, which promoted M2-like MDM phenotypes in a paracrine pathway, thereby contributing to T cell exhaustion to induce GBM immune escape. In translational medicine, combinations of the OGT inhibitor by targeting WTAP expression and the LOXL2 antagonist by disrupting MES GSC and MDM interactions showed favorable outcomes to the anti-PD1 immunotherapy.
Conclusions: WTAP plays critical roles in mesenchymal transition of GSCs and formation of TIME, highlighting the therapeutic potential of targeting WTAP and its downstream effectors to enhance the efficacy of immunotherapy.
3 MHz space antenna
Authors: Katz J I , Krassner J 
Published: December 2024

ABSTRACT
Little is known about the radio astronomical universe at frequencies below 10 MHz because such radiation does not penetrate the ionosphere. A Cubesat-based antenna for the 1–10 MHz band could be rapidly and economically deployed in low Earth orbit. When shielded by the Earth from Solar emission, it could observe weak extra-Solar System and outer Solar System sources. We suggest possibly observable sources, and application to study of the topside ionosphere.
Saving externality: when depositing too much breaks the bank
Authors: Leonello Agnese , Mendicino Caterina , Panetti Ettore , Porcellacchia Davide 
Published: December 2024

Abstract
This article highlights a novel channel through which the level of deposits matters for bank fragility and efficiency. We augment a global-game model of bank runs with a consumption-saving choice that determines deposit size in the initial period. We derive two key results. First, depositors’ incentives to run increase with the amount of savings held as bank deposits. Second, a saving externality emerges because individual depositors fail to internalize the impact of their deposit decisions on the likelihood of a bank run. This leads to depositors’ over-saving and inefficient bank liquidity provision, as well as excessive bank fragility. Finally, we characterize the optimal policy to implement the efficient allocation.
No evidence for an association of testosterone and cortisol hair concentrations with social decision-making in a large cohort of young adults
Authors: Massaccesi Claudia , Johnson-Ferguson Lydia , Zimmermann Josua , Ehlert Alexander , Baumgartner Markus R , Binz Tina M , Ribeaud Denis , Eisner Manuel P , Shanahan Lilly , Rauhut Heiko , Quednow Boris B 
Published: December 2024

Abstract
Prior research has established that testosterone is an important modulator of social decision-making. However, evidence on the relationship between basal testosterone levels, commonly measured in saliva or blood, and social behavior has been inconsistent due to methodological shortcomings. Additionally, it has been suggested that cortisol might moderate the association between basal testosterone and social behavior. The present study examined how individual differences in cumulative hair testosterone map onto social decision-making under consideration of a potential modulating role of hair cortisol in a large community sample of young adults (N = 1002). We observed a negative association between hair testosterone and trust behavior (odds ratio = 0.84) and a positive association with self-reported aggressive behavior (β = 0.08). The effects were small and became nonsignificant after controlling for key covariates of steroid hormones in hair (e.g. hair color, contraceptives, and use of psychoactive substances). Hair testosterone levels were not significantly associated with any other social behavior examined, and no modulating effects of hair cortisol were found. Overall, these findings provide no evidence for a role of basal testosterone hair concentrations in human social decision-making and do not indicate that hair cortisol moderates hair testosterone’s effects on social behavior.
Graph analysis of guilt processing network highlights links with subclinical anxiety and self-blame
Authors: Zareba Michal Rafal , Bielski Krzysztof , Costumero Victor , Visser Maya 
Published: December 2024

Abstract
Maladaptive forms of guilt, such as excessive self-blame, are common characteristics of anxiety and depressive disorders. The underlying network consists of multiple associative areas, including the superior anterior temporal lobe (sATL), underlying the conceptual representations of social meaning, and fronto-subcortical areas involved in the affective dimension of guilt. Nevertheless, despite understanding the circuitry’s anatomy, network-level changes related to subclinical anxiety and self-blaming behaviour have not been depicted. To fill this gap, we used graph theory analyses on a resting-state functional and diffusion-weighted magnetic resonance imaging dataset of 78 healthy adults (20 females, 20–35 years old). Within the guilt network, we found increased functional contributions of the left sATL for individuals with higher self-blaming, while functional isolation of the left pars opercularis and insula was related to higher trait anxiety. Trait anxiety was also linked to the structural network’s mean clustering coefficient, with the circuitry’s architecture favouring increased local information processing in individuals with increased anxiety levels, however, only when a highly specific subset of connections was considered. Previous research suggests that aberrant interactions between conceptual (sATL) and affective (fronto-limbic) regions underlie maladaptive guilt, and the current results align and expand on this theory by detailing network changes associated with self-blame and trait anxiety.
Inert splint-driven oligonucleotide assembly
Authors: Mishin Andrew A , Groth Tobin , Green Richard E , Troll Christopher J 
Published: December 2024

Abstract
In this study, we introduce a new in vitro method for oligonucleotide fragment assembly. Unlike polymerase chain assembly and ligase chain assembly that rely on short, highly purified oligonucleotides, our method, named Splynthesis, uses a one-tube, splint-driven assembly reaction. Splynthesis connects standard-desalted “contig” oligos (∼150 nt in length) via shorter “splint” oligos harboring 5ʹ and 3ʹ blocking modifications to prevent off-target ligation and amplification events. We demonstrate the Splynthesis method to assemble a 741-bp gene fragment. We verify the assembled polymerase chain reaction product using standard molecular biology techniques, as well as long-read Oxford Nanopore sequencing, and confirm that the product is cloneable via molecular means, as well as Sanger sequencing. This approach is applicable for synthetic biology, directed evolution, functional protein assays, and potentially even splint-based ligase chain reaction assays.
Insights into the phylogeny of longhorn beetles from phylogenomic data
Authors: Song Nan , Wang Miaomiao , Zhai Qing , Zhang Huanhuan 
Published: December 2024

Abstract
Cerambycidae (Coleoptera: Chrysomeloidea) are a widely distributed group of insects with significant economic importance. Despite substantial efforts and some advancements in inferring the phylogeny of Cerambycidae, high-level phylogenetic relationships within the family, including subfamily and tribe-level classification, remain contentious. In this study, we performed whole-genome sequencing on a total of 65 species. We integrated these comprehensive genomic data with existing whole-genome and transcriptome data to conduct a phylogenetic analysis of Cerambycidae s.s. The results supported the monophyly of Lamiinae, Cerambycinae, and Spondylidinae, whereas Lepturinae and Prioninae were found to be non-monophyletic. Lamiinae were recovered as the sister group to all other Cerambycidae s.s. Spondylidinae were found to be sister to the clade comprising Lepturinae and Necydalinae, and Cerambycinae were identified as the sister group to the clade consisting of Prioninae and Parandrinae. Within Lamiinae, the tribes Mesosini, Saperdini, and Dorcaschematini were found to be monophyletic; however, Acanthocinini, Agapanthiini, Pogonocherini, Pteropliini, Lamiini, and Monochamini were non-monophyletic. This study supported the classification integrating the current Monochamini into Lamiini. Molecular dating analysis suggests that diversification within Cerambycidae s.s. began at the boundary between the Jurassic and Cretaceous periods, ~145 Mya.
Neurocranial anatomy of Paralligator (Neosuchia: Paralligatoridae) from the Upper Cretaceous of Mongolia
Authors: Kuzmin Ivan T , Sichinava Ekaterina A , Mazur Evgeniia V , Gombolevskiy Victor A , Sennikov Andrey G , Skutschas Pavel P 
Published: December 2024

Abstract
Neurocranial features appear to be phylogenetically informative and key in assessing the still contentious relationships within Crocodylomorpha. However, the braincases of many non-crocodylian taxa are incompletely studied precluding the assessment of evolutionary modifications at the base of Crocodylia. Here, we describe the braincase osteology and neuroanatomy of the paralligatorid crocodylomorph Paralligator from the Upper Cretaceous of Mongolia based on computed tomography (CT)-scanning, segmentation, and 3D modelling of several specimens. The anatomy of the brain endocast, nerves, and the paratympanic pneumatic cavities of Paralligator is consistent with its phylogenetic position close to or at the base of Eusuchia. Paralligator shares a suit of neuroanatomical features with basal eusuchians and crocodylians reflecting the plesiomorphic condition for Crocodylia. In addition, differences in the brain endocasts between the larger-sized individuals of Paralligator and Kansajsuchus and the smaller Shamosuchus are consistent with ontogenetic changes in extant crocodylians. This suggests that members of the more basal clade Paralligatoridae and the crown-group Crocodylia share similar brain modifications during ontogeny. We also review the distribution of the mesethmoid in Crocodylomorpha and show its presence in several clades including Paralligatoridae and Dyrosauridae.