bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival of silver diamine fluoride among patients treated in community dental clinics: A naturalistic study
Authors: Raskin Sarah Elaine , Tranby Eric P , Ludwig Sharity , Okunev Ilya , Frantsve-Hawley Julie , Boynes Sean 
Published: January 2021

Abstract
Background: Silver diamine fluoride (SDF) is a minimally-invasive preventive service used in the U.S. to avert and arrest caries since 2014. No studies document survival outcomes based in real world delivery. We analyzed 12-month survival outcomes of SDF applied independently or concurrently with other restorative procedures among a population receiving community dental care.Methods: We analyzed data on SDF applications from de-identified dental claims on Oregon Health Plan patients served by Advantage Dental in 2016, who had been seen in 2015 (patient n=2,269; teeth n=7,787). We compared survival rates of SDF alone, SDF applied with a sedative filling, and SDF with a same-day restoration. Failure was defined as a restoration or extraction of the tooth 7 to 365 days after initial application. Survival was defined as a patient returning 180 or more days after application whose tooth did not have a restoration or extraction. Differences were assessed through Wilcoxon equality of survivor function tests and log-rank equality of survivor tests to compare failure rates, Cox Proportional Hazards models to assess factors associated with survival of SDF, and Kaplan-Meier survival estimate to calculate the probability of survival over time. Results: SDF alone had an overall survival rate of 76%. SDF placed with sedative filling and with a same-day restoration had survival rates of 50% and 84% respectively, likely reflecting treatment intent. SDF alone survived exceptionally well on primary cuspids, permanent molars, and permanent bicuspids and among patients aged 10 to 20 years, with modest variation across caries risk assessment categories. A single annual application of SDF was successful in 68% of cases. Among SDF failures on permanent dentition, more than two-thirds of teeth received a minor restoration. Conclusions: SDF is a minimally invasive non-aerosolizing option that prevented non-cavitated lesions and arrested early decay among community dentistry patients when applied independently or concurrently with restorative procedures. Professional organizations, policy makers, providers, and payors should broaden optional SDF use by informing clinical guidelines, reimbursement policies, and treatment decisions. Future research should address clinical, social, service delivery, workforce, and economic outcomes using diverse population-based samples, and the mechanisms underlying single application success and caries prevention potential.
The use of dried tube specimens of&nbsp;Plasmodium falciparum&nbsp;in an external quality assessment programme to evaluate health worker performance for malaria rapid diagnostic testing in healthcare centres in Togo
Authors: DORKENOO Monique Ameyo , Kouassi Kafui Codjo , Koura Adjane K. , Adams Martin L , Gbada Komivi , Katawa Gnatoulma , Yakpa Kossi , Charlebois Remi , Milgotina Ekaterina , Merkel Michele O , Aidoo Michael 
Published: January 2021

Abstract
BackgroundThe use of rapid diagnostic tests (RDTs) to diagnose malaria is common in sub-Saharan African laboratories, remote primary health facilities and in the community. Currently, there is a lack of reliable methods to ascertain health worker competency to accurately use RDTs in the testing and diagnosis of malaria. Dried tube specimens (DTS) have been shown to be a consistent and useful method for quality control of malaria RDTs, however, its application in National Quality Management programmes has been limited.MethodsA Plasmodium falciparum strain was grown in culture and harvested to create DTS of varying parasite density (0, 100, 200, 500 and 1,000 parasites/µL). Using the dried tube specimens as quality control material, a proficiency testing (PT) programme was carried out in 80 representative health centres in Togo. Health worker competency for performing malaria RDTs was assessed using five blinded DTS samples, and the DTS were tested in the same manner as a patient sample would be tested by multiple testers per health centre. ResultsAll the DTS with 100 parasites/µl and 50% of DTS with 200 parasites/µl were classified as non-reactive during the pre-PT quality control step. Therefore, data from these parasite densities were not analysed as part of the PT dataset. PT scores across all 80 facilities and 235 testers was 100% for 0 parasites/µl, 63% for 500 parasites/µl and 93% for 1,000 parasites/µl. Overall, 59% of the 80 healthcare centres that participated in the PT programme received a score of 80% or higher on a set of 0, 500 and 1,000 parasites/ µl DTS samples. Sixty percent of health workers at these centres recorded correct test results for all three samples.ConclusionsThe use of DTS for a malaria PT programme was the first of its kind ever conducted in Togo. The ease of use and stability of the DTS illustrates that they this type of samples can be considered for the assessment of staff competency. The implementation of quality management systems, refresher training and expanded PT at remote testing facilities are essential elements to improve the quality of malaria diagnosis.
The radiomics features could be used to predict the distinct metastases in nasopharyngeal carcinoma patients
Authors: Li Meige , Feng Ziyou , Yang Fang , Zhan ZeJiang , Ye Haiwen , Zhang Guoyi 
Published: January 2021

Abstract
Background For NPC patients, distant metastasis is now the main reason for treatment failure. The patients with distinct metastases need different therapeutic regimen and have distinct prognosis. Radiomics might help us predict the type of metastases effectively.Methods The MRI data of seventy non-metastatic NPC patients who develop distant metastasis within five years after treatment were collected and 4410 radiomics features for each patient were extracted by PyRadiomics. Every radiomics feature were compared among patients with distinct metastases and tested by the receiver operating characteristic curve.Results Twenty features have significant differences between the bone metastases cohort and lung metastases cohort, two features have significant differences between the bone metastases cohort and liver metastases cohort, one feature has significant differences between the bone metastases cohort and multiple metastases cohort and sixty-seven features have significant differences between the lung metastases cohort and liver metastases cohort. Six T2WI features could identified lung metastases from bone metastases and liver metastases effectively (AUC=0.851~0.896), two T1WI features and one CE T1WI feature could respectively identified bone metastases from liver metastases and multiple metastases effectively (AUC=0.779~0.821).Conclusion The results indicate that the radiomics features could reflect some of the characteristics of distinct metastases and have potential to be used as predictor of distinct metastases.
Development of a Multi-gene-based Immune Prognostic Signature in Ovarian Cancer
Authors: cao tiefeng , shen huimin 
Published: January 2021

Abstract
Background： Various components of the immune system play a critical role in the prognosis and treatment response in ovarian cancer (OC). Immunotherapy has been recognized as a hallmark of cancer but the effect is contradictional. Reliable immune gene-based prognostic biomarkers or regulatory factors are necessary to be systematically explored to develop an individualized prediction signature.Methods: This study systematically explored the gene expression profiles in patients with ovarian cancer from RNA-seq data set for The Cancer Genome Atlas (TCGA). Differentially expressed immune genes and transcription factors (TFs) were identified using the collected immune genes from ImmPort dataset and TFs from Cistoma database. Survival associated immune genes and TFs were identified in terms of overall survival. The prognostic signature was developed based on survival associated immune genes with LASSO (Least absolute shrinkage and selection operator) Cox regression analysis. Further, we performed network analysis to uncover the potential regulators of immune-related genes with the help of computational biology. Results: The prognostic signature, a weighted combination of the 21 immune-related genes, performed moderately in survival prediction with AUC was 0.746, 0.735, and 0.749 for 1, 3, and 5 year overall survival, respectively. Network analysis uncovered the regulatory role of TFs in immune genes. Intriguingly, the prognostic signature reflected the immune cells landscape and infiltration of some immune cell subtypes.Conclusions: We first constructed a signature with 21 immune genes of clinical significance, which showed promising predictive value in the surveillance, and prognosis of OC patients.
Best practice guidelines in managing the craniofacial aspects of skeletal dysplasia
Authors: Savarirayan Ravi , Tunkel David E. , Sterni Laura M. , Bober Michael B. , Cho Tae-Joon , Goldberg Michael J , Hoover-Fong Julie , Irving Melita , Kamps Shawn E. , Mackenzie William G. , Raggio Cathleen , Spencer Samantha A. , Bompadre Viviana , White Klane 
Published: January 2021

Abstract
Background: Recognition and appropriate management of the craniofacial manifestations of patients with skeletal dysplasia are challenging, due to the rarity of these conditions, and dearth of literature to support evidence-based clinical decision making.Methods: Using the Delphi method, an international, multi-disciplinary group of individuals, with significant experience in the care of patients with skeletal dysplasia, convened to develop multi-disciplinary, best practice guidelines in the management of craniofacial aspects of these patients.Results: After a comprehensive literature review, 23 initial statements were generated and critically discussed, with subsequent development of a list of 22 best practice guidelines after a second round voting.Conclusions: The guidelines are presented and discussed to provide context and assistance for clinicians in their decision making in this important and challenging component of care for patients with skeletal dysplasia, in order standardize care and improve outcomes.
ESTRATÉGIAS DE GESTÃO DE ESTOQUE HOSPITALAR EM ORGANIZAÇÕES PÚBLICAS NO BRASIL: UM ESTUDO DE CASO
Authors: Lopes de Souza Claudia , Gerardin Poirot Land Marcelo 
Published: January 2021

O estudo tem por objetivo descrever a gestão de estoque de um serviço público hospitalar de ensino e avaliar estratégias de planejamento de compras públicas viáveis à ampla utilização em organizações públicas de saúde.
O estudo foi conduzido por meio de abordagem multimetodológica. Uma primeira etapa exploratória do sistema de gestão de estoque vigente no Hospital Universitário Clementino Fraga Filho e a segunda etapa uma análise quantitativa de estratégias de gestão e seu impacto físico-orçamentário.
A análise do caso apontou que o hospital de ensino em questão possui um bom controle de estoque, porém, não se utiliza de nenhum método formal de planejamento de compras além de não controlar custos e seu impacto orçamentário.
Problemas multifatoriais exigem soluções integradas. Aumentar orçamento nem sempre possibilitará comprar melhor. Criar consórcios hospitalares, monitorar custos de perda e manutenção de estoques, utilizar modelos enxutos e coordenados são medidas imprescindíveis para gestão pública de qualidade.
Palavras-chave: logísticahospitalar, gestão de estoque, planejamento de compras
Sliding Mode Control of an Actuated Knee Joint Orthosis
Authors: Saidi Imen , Hammami Asma 
Published: January 2021

Introduction::
In this paper, a robust sliding mode controller is developed to control an orthosis used for rehabilitation of lower limb.

Materials and Methods::
The orthosis is defined as a mechanical device intended to physically assist a human subject for the realization of his movements. It should be adapted to the human morphology, interacting in harmony with its movements, and providing the necessary efforts along the limbs to which it is attached.

Results::
The application of the sliding mode control to the Shank-orthosis system shows satisfactory dynamic response and tracking performances.

Conclusion::
In fact, position tracking and speed tracking errors are very small. The sliding mode controller effectively absorbs disturbance and parametric variations, hence the efficiency and robustness of our applied control.
Neurokinin-1 Receptor Antagonist Can Prevent the Delayed Phase in Patients: A Single Center Retrospect Study
Authors: Xu Jing , Tang Shuhui , Li Jie , Wang Wei , Wu Meihong , Zhan Xianbao 
Published: January 2021

Background:
Neurokinin-1 receptor antagonists are playing a major advance in Chemotherapy-Induced
Nausea and Vomiting (CINV) as powerful prophylactic agents. Therefore, it is significant to find the association
between risk factors of patients and CINV so as to adjust the anti-emetic regimens.

Objective:
To evaluate the role of Neurokinin-1 Receptor (NK-1R) antagonist in preventing chemotherapy-induced
vomiting in the acute and delayed phases following the first cycle of treatment.

Methods:
145 adult patients with various cancers were recruited in Shanghai Changhai Hospital between
September 2017 to November 2017, receiving dual or triple antiemetics.

Results:
NK-1R antagonist combined with dexamethasone, 5-HT3R antagonist could effectively control delayed-
vomiting in patients after Cycle 1 chemotherapy treatment (4.1% vs. 15.6%, P = 0.041<; 0.05). This
study also showed that a history of motion sickness was a predictor of chemotherapy-induced vomiting (CINV)
(P = 0.023 <; 0.05). In delayed phase a low consumption of alcohol and history of CIV for males were also significantly
associated with CINV (P = 0.036 <; 0.05 and P = 0.002 <; 0.05 respectively).

Conclusion:
In this study, we found that triple anti-emetic regimen with NK-1R antagonist could effectively
prevent the delayed-vomiting than dual agents. Moreover, some risk factors were observed to be associated
with CINV in the delayed phase.
Alpha-Terpineol as Antitumor Candidate in Pre-Clinical Studies
Authors: Negreiros Helber A. , de Moura Kariely Gonçalves , Barreto do Nascimento Maria L.L. , do Nascimento Rodrigues Débora Caroline , Ferreir Paulo M.P. , Braz Débora C. , de Farias Marlene Gomes , de Sousa Corrêia Layde , Pereira Ana R.S. , Santos Lubna K.B. , Gonçalves Juan C.R. , Mendes Anderson N. , Carneiro da Silva Felipe C. , Cavalcant Ana A.C.M. , de Castro e Sousa Joáo Marcelo 
Published: January 2021

Background:
Alpha-terpineol is monoterpene alcohol with anti-tumor activity against different tumor
cell lines (lung, breast, leukemias and colorectal) through blockage of NF-kB expression, which play an important
role in tumor cells growth.

Objective:
Evaluate the antitumor activity of alpha-terpineol in murine Sarcoma 180 cell line

Methods::
For the tests, different cytotoxic and genotoxic assays were used, including Trypan blue, cytokinesis-
blocked micronucleus assay, comet assay, agarose gel DNA fragmentation, flow cytometry and cell viability
using fluorescence. Ascitic fluid cells from sarcoma 180 were obtained from Mus musculus peritoneal cavity
and Alpha-terpineol was tested at 100, 250 and 500 μg/mL. Doxorubicin and Cisplatin were used as positive
controls.

Results:
Cytotoxic effects of alpha-terpineol were found in all concentrations tested, reducing cell viability in
50.9; 38.53; 30.82% at 100, 250 and 500 μg/mL, respectively. Alpha-terpineol induced genotoxic effects due to
DNA fragmentation (increased frequency and index of damage), and was clastogenic by increased micronuclei
formation, nucleoplasmic bridges and nuclear buds. DNA fragmentation and increased cell death indicated that
alpha-terpineol can cause early, late, and necrotic apoptosis.

Conclusion:
Our data indicate that alpha-terpineol has antitumor activity revealed by cytogenetic mechanisms and / or loss of cell membrane integrity.
Profile of Secondary Bacterial Respiratory Infections in H1N1 Patients Admitted in a Tertiary Care Centre – A Four-year Retrospective Study
Authors: Khan Noorelle Karim , Shenoy Suchitra , Madi Deepak , Kulkarni Vaman 
Published: January 2021

Background:
H1N1 is known to cause periodic seasonal flu in the Indian subcontinent
since 2009. The clinical course and the underlying immunity of the host contribute to the development
of secondary bacterial infections in the infected patients.

Objectives:
This study aims to analyze the secondary bacterial infections in confirmed H1N1 cases
admitted in our hospital (from 2015 to 2018) with respect to the comorbidities, complications, associated
bacteria with its antibiotic susceptibility pattern, and the outcome of such episodes.

Material and methods:
Data of 164 patients admitted in a tertiary care hospital with H1N1 was extracted
from medical records using a semi-structured case report form. Data were entered and analyzed
with SPSS version 17. A p-value of <0.05 was considered statistically significant.

Results:
Most patients were aged above 40 years with female preponderance. In our study, 42% of
patients had comorbidities. Only 14 (8.53%) had secondary bacterial infection confirmed by culture.
Klebsiella pneumoniae and Acinetobacter baumannii were the most common bacteria that
were isolated. They were treated based on the culture reports. There was no mortality in patients
with a secondary bacterial infection.

Conclusion:
The early start of the antiviral agents and adherence to the antibiotic policy of the hospital
contributed to lower secondary bacterial infections and zero mortality.
COVID-19 #StayAtHome Restrictions and Deep Vein Thrombosis: Case Report
Authors: Blum Edna , Abdelwahed Youssef S , Spiess Eileen , Mueller-Werdan Ursula , Leistner David M , Rosada Adrian 
Published: January 2021

Background
The COVID-19 pandemic triggered countermeasures like #StayAtHome initiatives, which have changed the whole world. Despite the success of such initiatives in limiting the spread of COVID-19 to #FlattenTheCurve, physicians are now confronted with the adverse effects of the current restrictive pandemic management strategies and social distancing measures.

Objective
We aim to draw attention to the particular importance and magnitude of what may be the adverse effects of COVID-19–related policies.

Methods
We herein report a case of an otherwise healthy 84-year-old woman with deep vein thrombosis (DVT) due to COVID-19–related directives. #StayAtHome policies and consequential social isolation have diminished our patient’s social life and reduced her healthy movement behaviors. The patient spent long hours in a seated position while focusing on the intensive flow of media information regarding the pandemic.

Results
Reduced mobility due to preventive social isolation during the COVID-19 pandemic was the only identified cause of the DVT.

Conclusions
While evaluating the effect of the COVID-19 pandemic and governmentally implemented containment measures, including social isolation and mobility reduction, adverse events should be considered. Digital approaches might play a crucial role in supporting public health.
Methanol Dehydration to Dimethyl Ether over Modified γ-Al2O3 with Acid, Base and Zeolite (NaA and NaX)
Authors: Ulfah Maria , Suherman Hendra , Laniwati Melia , Makertihartha IGBN , Subagjo Subagjo 
Published: January 2021

The effect of acids, bases, zeolite NaA and zeolite NaX impregnation to g-Al2O3 on the catalyst characteristics and activity against methanol dehydration reaction were investigated. The catalyst characteristics include N2 physisorption, X-ray diffraction (XRD), and temperature-programmed desorption of ammonia (NH3-TPD) in addition to catalytic dehydration of methanol performed in a micro fixed-bed reactor at 270°C and 1 atm. The results of XRD characterization showed no changes related to the modification of alumina over acids, bases, and zeolite NaA and zeolite NaX. Therefore, the modification did not have any effect on the crystalline structure of alumina. The textural and surface acidity of g-Al2O3 changed post addition of acids, bases, zeolite NaA and zeolite NaX. NH3-TPD analysis results demonstrated that synthesized g-Al2O3 has three types of acid sites: weak, medium, and strong; however, the weak acid sites were not observed on alumina catalysts modified phosphate, KOH, zeolite NaA, and zeolite NaX. Furthermore, the concentration of strong acid sites increased in the catalyst containing KOH. The catalytic test results showed that the untreated g-Al2O3 catalyst gave prominent activity in dehydration of methanol compared to the treated catalyst following the number and strength of acid sites.
VILÕES E ANTI-HERÓIS: PERCEPÇÕES DE ADOLESCENTES SOBRE LIDERANÇAS POLÍTICAS
Authors: D’Auria-Tardeli Denise , da Silva Barros Lucian 
Published: January 2021

Este artigo refere-se a um estudo de prevalência de caráter quanti-qualitativo que objetivou compreender as percepções que adolescentes têm sobre o perfil de um líder político e como representam a construção de uma identidade voltada para a formação ética. A coleta com 219 adolescentes entre 10 e 13 anos consiste em um questionário escrito e elaborado para esta pesquisa, com foco em vilões e anti-heróis da TV e do cinema. A linha teórica se concentra na área da Psicologia da Educação e os resultados mostram como os jovens internalizam seus valores a partir de modelos significativos, como projetam a sua participação social, e como constroem elementos identitários para o civismo.
Cytotoxic Assay of Semipolar Fraction Of Ethanolic Extract From Sugar Apple (Annona Squamosa L.) Stem Bark on T47D Cells
Authors: Muflihah Cita Hanif , Haryoto Haryoto , Indrayudha Peni 
Published: January 2021

Previous research has shown that some compounds in leaves and seeds of sugar apple have a cytotoxic activity. The aim of this research was to determine the cytotoxicity of semipolar fraction of ethanolic extract from sugar apple stem bark (Annona squamosa L.) on T47D cancer cells. The semipolar fraction of ethanolic extract from sugar apple stem bark was collected by fractionation using Vacuum Liquid Chromatography (VLC) with hexane:ethyl acetic (9:1, 8:2, 7:3, and 6:4) as mobile phase. Cytotoxicity from the fractions of five different concentration namely; 25, 50, 100, 150, and 250, µg/mL was measured by MTT assay. The potency of the cytotoxicity was defined by the ability of the fraction to inhibit the growth of T47D cells indicated by the value of IC50. Qualitative analysis of contained compounds in the fraction was done by Thin Layer Chromatography (TLC) method using silica gel F 254 as a stationary phase and hexane:ethyl acetic (7:3) as a mobile phase. UV 254 and 366 nm lamp also Dragendorff, citroboric, and FeCl3 spray reagents were used to visualize the spots of the secondary metabolites. The result proved that the semipolar fraction of ethanolic extract from sugar apple stem bark showed potential cytotoxicity on T47D cancer cells with IC50value of 70,77 µg/mL. Qualitative analysis showed that the fraction contained flavonoids and alkaloids which is presumably responsible for its cytotoxic activity.