bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Keragaman Genetik dan Kekerabatan Genotipe Ubi Jalar Berdasarkan Karakter Morfologi
Authors: Lestari Sri Umi , Julianto Reza Prakoso Dwi 
Published: November 2020

Ubi jalar (Ipomoea batatas (L.) Lam.) merupakan komoditas sumber karbohidrat setelah padi, jagung dan ubi kayu. Saat ini produktivitas ubi jalar nasional hanya sebesar 13,51 t/ha, lebih rendah dibandingkan hasil penelitian yang mencapai 35 t/ha. Penelitian ini bertujuan untuk mengevaluasi karakter morfologi beberapa genotipe ubi jalar dan menganalisis jarak genetik genotipe-genotipe berdasarkan karakter kuantitatif. Hasil analisis kekerabatan dari 13 genotipe ubi jalar berkelompok pada 2 klaster (A dan B). Kemiripan antargenotipe didasarkan pada jarak Euclidean; terdapat dua kelompok genotipe yang memiliki nilai kemiripan tertinggi yaitu Beta 2--22 dengan Jago-OP-28, dan Beta 2--12 dengan Beta 2--15. Sepuluh variabel pengamatan yang mempengaruhi keragaman 13 genotipe tereduksi ke dalam empat komponen utama dengan nilai keragaman kumulatif sebesar 91,1%. Hasil analisis biplot dari 10 variabel pengamatan dengan menghilangkan empat variabel yang mempunyai vektor pendek mampu meningkatkan keragaman dari 59,7% menjadi 92,1%.
Seroprevalence of IgG and IgM anti-Toxoplasma gondii antibodies and associated risks factors in pregnant women of northern Durango, Mexico
Authors: Facio-Campos Rolando Adair , Alvarado-Esquivel Cosme , Olivas-Calderon Edgar 
Published: November 2020

Toxoplasmosis is caused by intracellular parasite Toxoplasma gondii (T. gondii). T. gondii infection in pregnancy can result in serious consequences for the developing fetus or newborn, including spontaneous abortion, hydrocephalus, and even death (1). The infection could be acquired by ingestion of food (raw or uncooked meat from infected animals), direct contact with cat feces or soil contaminated with oocysts. In 2012 Caballero-Ortega et al., (2) found an increase in the toxoplasmosis distribution in the north region (35%) finding the highest prevalence in coastal regions (67.5%) of México. There is no data historic available about this seroprevalence, specifically of the “Comarca Lagunera” of Durango State. Moreover, previous study of T. gondii seroprevalence in Durango City showed that 6.1% of pregnant woman of urban areas and 8.2% of rural areas were found positives (3). In 2018, 434 pregnant women who used the Health Services of Durango State in the “Comarca Lagunera Region” were studied with an average age of 22.2 years (± 5.95); we found four (0.92%) IgG and none (0.0%) IgM antibodies anti-T. gondii (Table I). Consumption of dried meat (OR = 16.5; 95% CI 1.7 – 161.48; p= 0.01) and sheep and goat meat (OR = 15.61; 95% CI 1.1 – 224.05; p= 0.043) were associated factors to the infection. Number and different types of pets and cats was not associated with anti-T. gondii antibodies. The “Comarca Lagunera” of Durango being a cattle zone, frequently local meat is consumed in general, representing a possible risk factor. It is particularly interesting since this study’s seroprevalence was 0.91% in a small area of Durango State, differing from the global prevalence in the State. Probably, this results could be due to Durango State having a geographical diversity, Durango capital is located in a valley, unlike the “Comarca Lagunera” region, which is a semi-desert zone with high environmental temperature (Up to 45°C), that could explain the reduced survival of oocysts which implies a subsequent investigation to this work.
Survive, Revive, Thrive: Chapter 2: Finding Your Compass
Authors: Blasingame Tom 
Published: November 2020

This is a particularly hard column to prepare. It is early October and I had hoped to tell you how being an SPE member and being an active part of SPE was part of your professional responsibilities/duty. It is, but we will save that discussion for later.
As I interact with our members-in-transition and young members I am struck by the profound reality that most don’t know what to do next. In addition, in North America, Europe, and elsewhere, the workforce continues to be reduced. Smaller companies struggle for access to capital and free cash flow (and many for their very existence). Despite this, I find that our members are uniquely devoted to our mission and to our industry - in particular to ensuring that we are able to contribute to the energy needs of a world in recovery.
Inter-Well Relationships Are Messy, But That Can Be a Good Thing
Authors: Rassenfoss Stephen 
Published: November 2020

Groups of wells communicate and interfere with and hit each other. It’s an unruly scene but it can offer some production benefits. The first of these stories looks at how competing fracture networks can add drainage in rock that might otherwise be missed and the tradeoffs that come with that benefit for those planning drilling and fracturing.
ConocoPhillips quantified the impact of these competing fractures at its four-well test site. A second story looks at how the operator used the site to track how fast those communication channels close up and to identify what could be the choke point causing it.
A third story looks at the method used by Devon Energy to measure the degree of interference between wells and is using to create more, cost-effective communication among wells.
A Temperature-Insensitive FBG Acceleration Sensor with Sinusoid-Shaped Curved Beams
Authors: Hong Li , Zhang Yuzi , Mu Ruwang , Li Yanan , Qiu Zhongchao 
Published: November 2020

Abstract
It is an important means to identify and evaluate the structural damage of buildings before and after earthquake disaster by using fiber Bragg grating acceleration sensor to obtain the natural frequency of building structure. In order to solve the problem of temperature cross sensitivity of fiber Bragg grating (FBG) in structural health monitoring, a novel acceleration sensor based on strain chirp effect which is insensitive to temperature is proposed. A kind of M-shaped double cantilever beam structure is developed. The fiber grating is pasted in the gradient strain region of the beam, and the chirp effect is produced under the action of non-uniform stress, and then the change of acceleration is converted into the change of reflection bandwidth to demodulate and eliminate the temperature interference. Through theoretical analysis, simulation and experimental verification with rectangular beam sensor. The results show that the sinusoidal curvature beam sensor is insensitive to the change of temperature and is more likely to produce chirp effect. The sensitivity is about 317 pm/g, and the natural frequency is 56 Hz.
Regulation of Transient Receptor Potential Canonical 4 Activity by Phospholipase C-δ1
Authors: Ko Juyeon , Myeong Jongyun , Kwak Misun , So Insuk 
Published: November 2020

Abstract
Transient receptor potential canonical (TRPC) channels are non-selective calcium-permeable cation channels. It is suggested that TRPC4β and TRPC5 channels are regulated by phospholipase C (PLC) signaling, and are especially maintained by phosphatidylinositol 4,5-bisphosphate (PIP2). The PLCδ subtype is the most Ca2+-sensitive form among the isozymes which cleaves phospholipids to respond to the calcium rise. In this study, we investigated the regulation mechanism of TRPC channel by Ca2+, PLCδ1 and PIP2 signaling cascades. The interaction between TRPC4β and PLCδ1 was identified through the Fӧster resonance energy transfer (FRET) and co-immunoprecipitation (Co-IP). With the electrophysiological experiments, we found that TRPC4β-bound PLCδ1 reduces the overall whole-cell current of channel. The Ca2+-via opened channel promotes the activation of PLCδ1, which subsequently decreases PIP2 level. By comparison TRPC4β activity with or without PLCδ1 using differently [Ca2+]i buffered solution, we demonstrated that PLCδ1 functions in normal condition with physiological calcium range. The negative regulation effect of PLCδ1 on TRPC4β helps to elucidate the roles of each PIP2 binding residues whether they are concerned in channel maintenance or inhibition of channel activity.
Osteoinductive 3D Printed Scaffold Healed 5 cm Segmental Bone Defects in the Ovine Metatarsus
Authors: Yang Yunzhi Peter , Labus Kevin , Gadomski Benjamin , Bruyas Arnaud , Easley Jeremiah , Nelson Brad , Palmer Ross , Mcgilvray Kirk , Regan Daniel , Puttlitz Christian , Stahl Alexander , Maloney William , Gardner Michael 
Published: November 2020

Abstract
Autologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Recombinant human bone morphogenetic protein 2 (rhBMP-2) can stimulate bone regeneration and enhance the healing efficacy of bone grafts. The delivery of rhBMP-2 may even enable engineered synthetic scaffolds to be used in place of autologous bone grafts for the treatment of critical size defects, eliminating risks associated with autologous tissue harvest. We here demonstrate that an osteoinductive scaffold, fabricated by combining a 3D printed rigid polymer/ceramic composite scaffold with an rhBMP-2-eluting collagen sponge can treat extremely large-scale segmental defects in the sheep metatarsus. Bone regeneration after 24 weeks was evaluated by micro-computed tomography, mechanical testing, and histological characterization. Load-bearing cortical bridging was achieved in all animals, with increased bone volume observed in sheep that received osteoinductive scaffolds compared to sheep that received an rhBMP-2-eluting collagen sponge alone.
Does Climate Help Modeling COVID-19 Risk and to What Extent?
Authors: Scabbia Giovanni , Sanfilippo Antonio , Mazzoni Annamaria , Bachour Dunia , Perez-Astudillo Daniel , Benito Veronica Bermudez , Wey Etienne , Marchand-Lasserre Mathilde , Saboret Laurent 
Published: November 2020

Abstract
A growing number of studies has suggested potential impacts of meteorological variables on the spread of the COVID-19 pandemic. These impacts are supported by data from similar viral contagions, such as SARS and the 1918 Flu Pandemic, and corroborated by US influenza data relative to the last decade. However, there is still limited understanding about the extent to which meteorology affects COVID-19 transmission rates and how meteorology can be a relevant element to anticipate social and politic measures. This study demonstrates that such an understanding is attainable through the development of regression models that verify the contribution of meteorology to the modeling of COVID-19 transmission, and the use of feature importance techniques assessing the relative weight of meteorological variables compared to epidemiological, socioeconomic, environmental, and global health indicator factors. The study results show that meteorological factors play an important role in regression models of COVID-19 transmission that have low error rates (R2 0.964). These results are corroborated by a panel data fixed-effect model showing that meteorological coefficients are often significantly correlated with COVID-19 transmission rates (R2 0.691-0.746, p<0.01).
Plasma level of matrix metalloproteinase-9 in patients with sickle cell disease and its correlation to myocardial iron overload
Authors: Hassan Tamer , Badr Mohamed , Arafa Mohamed , Rahman Doaa Abdel , Fathy Manar , Elhewala Ahmed , Raafat Nermin , Hanna Diana 
Published: November 2020

Abstract
Cardiac iron overload is secondary to chronic blood transfusion in patients with sickle cell disease (SCD). Iron overload cardiomyopathy is a restrictive cardiomyopathy associated with systolic and diastolic dysfunction. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for tissue remodeling. Many studies offer strong evidence for the role of MMP-9 in LV remodeling. We aimed to detect plasma levels of MMP-9 in patients with SCD and its correlation to myocardial iron overload. A case control study was carried out on 50 patients with SCD and 50 age and sex matched healthy controls. Assessment of cardiac iron overload in patients by MRI T2* was performed. Plasma MMP-9 levels were measured for patients and controls using ELISA. SCD patients had significantly higher levels of MMP-9 than controls. There was highly significant correlation between plasma levels of MMP-9 and serum ferritin. Patients with vaso-occlusive crises (VOC) > 5/year had significantly higher levels of MMP-9 than those with VOC ≤ 5 /year. No significant correlation was found between MMP-9 and cardiac T2*. MMP-9 seems to be a useful marker in SCD patients. Patients with serum ferritin > 1000 ng/ml, recurrent VOC > 5 /year had significantly higher MMP-9 serum levels than others.
Wind-driven Advection Across Temperature Gradients Supports Phytoplankton Blooms in the Iron-limited Antarctic Polar Front
Authors: Brandini Frederico , Silver Adrienne , Gangopadhyay Avijit 
Published: November 2020

Abstract
We demonstrate how the wind-driven Ekman transport enhances the advection and mixing of cells from the colder waters of the Surface Antarctic Waters from the south to the warmer waters of the northern Polar Front (PF) belt. This mechanism provides cells a mean ambient temperature near optimum levels for species-specific and, ultimately, community growth rates high enough to develop blooms under non-light limiting, macronutrients and iron conditions. A Lagrangian trajectory model was constructed for tracking plankton cells as tracers forced by winds and surface currents. We argue that wind-driven Ekman drift of surface currents can carry phytoplankton cells into warmer waters and thus increase their growth rates to potentially generate blooms, even under iron-limiting conditions. Depending on the region along the circumpolar front, increased winds can enhance this process, and further accelerate such temperature-controlled growth.
Direct medical costs after surgical or nonsurgical treatment for degenerative lumbar spinal disease: a nationwide matched cohort study with a 10-year follow-up
Authors: Kim Chi Heon , Chung Chun Kee , Choi Yunhee , Lee Juhee , Yang Seung Heon , Lee Chang Hyun , Park Sung Bae , Rhee John , Park Moon Soo 
Published: November 2020

Abstract
Demand for degenerative lumbar spinal disease treatments has been increasing, leading to the increased utilization of medical resources. The present study compared the direct costs between surgical and nonsurgical treatment. The national health insurance service sample cohort was used in a matched cohort study comparing surgical treatment (n=2,698) with nonsurgical treatment (n=2,698). Insurance covers both Western and Asian medicine. First, the overall monthly costs were compared between cohorts. Second, the monthly costs were compared at 1, 3, 6, 9, and 12 months after treatment and yearly thereafter for 10 years. The surgery cohort spent $50.84/patient/month, and the nonsurgery cohort spent $29.34/patient/month (p<0.01). Surgery cost more ($2,762) than nonsurgical interventions ($180.4) (p<0.01). Compared with the nonsurgery cohort, the surgery cohort paid $33/month more for the first 3 months, paid less for the first 12 months, and paid approximately the same over the course of 10 years. Surgery initially cost more than nonsurgical interventions, but the costs incurred during the follow-up period were not higher. The results of the present study should be interpreted in light of the costs of medical services, indirect costs, quality of life and societal willingness to pay.
Chemical Oxygen Demand and Ammonia Nitrogen Mycoremediation from Domestic Wastewater Effluent using Ganoderma lucidum in a Batch System.
Authors: Mooralitharan Silambarasi , Hanafiah Zarimah , Manan Teh Sabariah Abd , Hasan Hassimi , Jensen Henritte , Wan-Mohtar Wan Abd Al Qadr Imad , Mohtar Wan Hanna Melini Wan 
Published: November 2020

Abstract
The fungi-based technology, wild-Serbian Ganoderma lucidum (WSGL) as myco-alternative to existing conventional microbial-based wastewater treatment is introduced in this study as a potential alternative treatment. The mycoremediation is highly persistent for its capability to oxidatively breakdown pollutant substrates and widely researched for its medicinal properties. Utilizing the non-hazardous properties and high degradation performance of WSGL, this research aims to find optimum conditions and model the mycoremediation treatment design for Chemical Oxygen Demand (COD) and Ammonia Nitrogen (AN) removal in domestic wastewater via response surface methodology (RSM). Combined process variables were temperature (⁰C) (Model 1) and the volume of mycelial pellets (%) (Model 2) against treatment time (hour). Response variables for these two sets of central composite design (CCD) were the removal efficiencies of COD (%) and AN (%). The regression line fitted well with the data with R2 values of 0.9840 (Model 1-COD), 0.9477 (Model 1-AN), 0.9988 (Model 2-COD) and 0.9990 (Model 2-AN). The lack of fit test gives the highest value of Sum of Squares equal to 9494.91 (Model 1- COD), 9701.68 (Model 1-AN), 23786.55 (Model 2-COD) and 13357.02 (Model 2-AN), with probability F values less than 0.05 showing significant models. The optimum conditions were established corresponding to the percentage of COD and AN removal obtained were 95.1% and 96.3%, accordingly at the optimum temperature 25°C at the treatment time of 24 h, meanwhile 0.25% of mycelial pellet with 76.0% and 78.4% COD and AN removal, respectively. The high performance achieved demonstrates that the mycoremediation of G. lucidum is highly potential as part of the wastewater treatment system in treating domestic wastewater of high organic loadings.
Epigenetic Clock Deceleration and Maternal Parity: Associations With Increasing Grey Matter Volume of the Precuneus
Authors: Nishitani Shota , Kasaba Ryoko , Hiraoka Daiki , Shimada Koji , Fujisawa Takashi , Tomoda Akemi 
Published: November 2020

Abstract
Reproductive effort experiences, such as pregnancy, delivery, and interaction with their children, make female maternal brains optimised for child-rearing. However, extensive studies in non-human species revealed there is a trade-off between reproductive effort and life expectancy. In humans, large demographic studies have shown that this is the case for the most part, but molecular marker studies of aging remain controversial, and there are no studies evaluating the relationship between reproductive effort, aging, and brain structures simultaneously. We examined the associations among the reproductive efforts, DNA methylation age acceleration, and the regional grey matter of structural brain scans by voxel-based morphometry in 27-46-year-old mothers. We found that greater reproductive efforts, including the number of delivery and motherhood periods, were significantly associated with decelerated aging in mothers with 1-4 children. We also found that the precuneus grey matter volume was larger as age deceleration occurred and found a mediation effect of the greater left precuneus grey matter volume on the relationship between parity and age deceleration. Our findings suggest that mothers of early childhood children who have less than four children may benefit from aging via precuneus structural changes.
New-onset focal seizure as a presenting feature of HIV infection⸻a case report and mini review to the challenge in resource-limited settings
Authors: Ayele Biniyam A. , Getu Zemichael , Samuel Amen 
Published: November 2020

Abstract
BackgroundThe frequency of new-onset HIV-associated seizure in the HIV-infected patient is estimated to be between 2% and 11%. Identifying the underlying etiology of new-onset seizure will have a vital impact on the mortality and morbidity of patients living with HIV infection.Case presentationWe report a 34-year old newly diagnosed HIV + male patient presented with abnormal body movement involving his right hemibody associated with loss of consciousness lasting few minutes of two weeks duration. The ABM occurred frequently (> five times per week) and associated with frothy and excessive salivation. He reported headache following each spells. Brain magnetic resonance imaging (MRI) showed bilateral frontal T2 and FLAIR hyperintensity and T1 hypointensity; post contrast study showed bilateral small ring enhancing lesions with perilesional edema, biggest on the left and measure 10 mm; considering patient advanced immunosuppression and underlying HIV infection, the brain MRI findings were consistent with cerebral toxoplasmosis. Bipolar montage electroencephalography (EEG) study showed generalized background slowing, prominent in the left fronto-centeral region. Patient was managed with combination antiretroviral therapy, anti-toxoplasmosis medication, and anticonvulsant. On follow up, the frequency of seizure attack has significantly reduced.ConclusionConsidering the high prevalence of HIV infection and associated seizure among people living with HIV in sub-Saharan Africa, this case fairly highlights on the importance of utilizing advanced imaging techniques such as MRI and EEG in identifying the underlying causes of HIV-associated seizures.
Effects of Short-term Low- to Moderate- Dose Glucocorticoids on Immuno-inflammatory Indicators and Prognosis of Patients With Regular and Severe COVID-19: A Retrospective Cohort Study
Authors: Zhang Jing , Kang Yi , Wang Hai-Bo , Liu Hai-Yang , Qi Ya-Nan , Tang Xia , Zhang Xiao-Ju , Qi Yong 
Published: November 2020

Abstract
Background: To explore the effects of short-term low- to moderate- dose glucocorticoids on the immune-inflammatory indicators and 28-d prognoses of patients with regular or severe coronavirus disease 2019 (COVID-19).Methods: The clinical data and laboratorial examination results of 66 patients with regular or severe type of COVID-19 that treated in Henan Provincial People’s Hospital and Nanyang Central Hospital between January 20 and February 14, 2020 were retrospectively analyzed. Here, 36 patients that had been treated with glucocorticoids were categorized in the glucocorticoids group (GC group), while the other 30 patients that had not been treated with glucocorticoids were categorized in the control group.Results: The immune-inflammatory indicators and prognoses of the patients in the two groups were compared. The sex, age, clinical types, and complications were not significantly different between the two groups (all P>0.05). After hospitalization, 33.3% and 6.7% of the patients in the GC group and control group were with chest distress, respectively, and the difference was statistically significant (P=0.019). The duration of fever was also significantly different between the two groups (6.91 ± 4.41 vs. 9.21 ± 4.46 days, P=0.036), but the blood examination results within 24 h after hospitalization were not significantly different between the two groups (all P>0.05). The C-reactive protein (CRP) and Interleukin-6 (IL-6) levels were lower in the GC group than control group on day 7 (P=0.012, P=0.035) but were not significantly different between the two groups on day 14. The CRP and IL-6 levels were significantly reduced after glucocorticoids treatment on day 3, 5 and 7 (all P<0.05) in GC group. The median time of hospital stay, and 28-d prognoses were not significantly different between the two groups (P=0.080, P>0.999).Conclusions: Glucocorticoids could decrease the levels of inflammatory indicators, but did not significantly influence other immune-related indicators and 28-d prognoses.