bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iliac venous stenting for outflow obstruction does not significantly change the quality of life of patients with severe chronic venous insufficiency
Authors: Shiferson Alexander , Aboian Edouard , Shih Michael , Pu Qinghua , Jacob Theresa , Rhee Robert Y 
Published: November 2019

Purpose Percutaneous endovenous iliac stenting has emerged as a new modality in the treatment of advanced chronic venous insufficiency with outflow obstruction. However, the effect of this intervention on the quality of life remains unclear. We examined the impact of iliac venous stenting for outflow obstruction as compared to conservative medical management on the quality of life in severe chronic venous insufficiency patients. Methods Medical records of all patients with CEAP class 5 and 6 disease (N = 172) who underwent ilio-caval venography with intravascular ultrasonography (IVUS) at a single institution over a seven-year period, were reviewed for this case–control study. Quality of life evaluation was performed utilizing the Chronic Venous Insufficiency Quality of Life Questionnaire (CIVIQ-20) one year after the index procedure. Results Of the 172 severe chronic venous insufficiency patients, 109 were stented and 63 patients were treated medically based on their venography and IVUS results. The indication for stenting was confirmation of IVUS determined surface area or diameter outflow stenosis of greater than 50% within the common or external iliac venous systems. Eighty patients (47%) responded with completed CIVIQ-20 questionnaires for analysis. Of these, 47 were from the stented group and 33 from the non-stented group. At least moderate persistent pain or discomfort post-procedure was reported by 20 (43%) stented group patients and 19 (58%) non-stented group patients. Scores for all the other criteria in the CIVIQ-20 were similar between the groups. The mean total CIVIQ-20 score was 45.23 and 47.13, respectively, in stented group and non-stented group patients. ( p = 0.678). Conclusion There was no significant difference in the quality of life reported by CEAP 5 and 6 patients who underwent iliac venous stenting versus those who were treated medically for presumed iliac outflow obstruction. Prospective studies are needed to determine the true value of iliac venous stenting based on IVUS criteria in the management advanced chronic venous insufficiency.
Serum levels of ferritin and transferrin serve as prognostic factors for mortality and survival in patients with end‐stage liver disease: A propensity score‐matched cohort study
Authors: Meier Jörn Arne , Bokemeyer Arne , Cordes Friederike , Fuhrmann Valentin , Schmidt Hartmut , Hüsing‐Kabar Anna , Kabar Iyad 
Published: November 2019

BackgroundPatients with end‐stage liver disease are known to suffer from a significantly high risk of mortality, but accurate prediction of the course of disease is challenging.ObjectiveThe study aim was to evaluate the independent prognostic and clinical importance of serum levels of ferritin and transferrin for 90‐day survival of patients with liver disease.MethodsPatients with end‐stage liver disease treated during a 2‐year period were enrolled retrospectively in a single‐centre study. Unmatched and propensity score matching (PSM) analyses were applied.ResultsThe study cohort comprised 286 patients with end‐stage liver disease, of which 22.9% died during the observational period. High serum ferritin levels and low serum transferrin levels were associated significantly with increased 90‐day mortality in the unmatched (p  < 0.001) and PSM study population (p  = 0.017). Serum levels of ferritin and transferrin had high prognostic capability to predict 90‐day survival similar to the Model for End‐stage Liver Disease. Patients with serum ferritin values >1030.5 µg/l had a 50% risk of dying within 11 days after measurement, which translated up to a 90‐day mortality of 83%.ConclusionSerum levels of ferritin and transferrin have independent and excellent capabilities to determine prognosis in patients with end‐stage liver disease. Ferritin measurements can reliably identify those with high mortality in daily practice.
China–Africa Education Cooperation: From FOCAC to Belt and Road
Authors: King Kenneth 
Published: November 2019

Purpose: The article discusses the relationship between the human resource traditions of the Forum on China–Africa Cooperation (FOCAC) and those supported by the Belt and Road Initiative (BRI), and in particular by the Education Action Plan for the Belt and Road Initiative, issued by the Chinese Ministry of Education (MOE) in 2016. Design/Approach/Methods: The article draws upon discourse analysis of both the FOCAC VI and VII documents and the key MOE 2016 Action Plan. Findings: Given the trans-continental coverage of the BRI, it is suggested that its ambitious pledges in respect of education and human resource development (HRD) actually complement or even exceed the commitments made by FOCAC VI and VII. Originality/Value: This is the first article explicitly to compare the HRD pledges of FOCAC with those associated with BRI’s Education Action Plan.
Does a Partial Rotator Cuff Tear Affect Pitching Ability? Results From an MRI Study
Authors: Park Jin-Young , Kim Junhyun , Lee Jae-Hyung , Oh Kyung-Soo , Chung Seok Won , Park Hyunjun 
Published: November 2019

Background: Numerous studies have examined changes in the athletic performance of baseball pitchers after rotator cuff surgery. However, only a few studies have evaluated changes in athletic performance caused by partial rotator cuff tears that are not treated surgically. Purpose: To examine the course of partial-thickness rotator cuff tears and its possible effect on the athletic performance of professional pitchers. Study Design: Case series; Level of evidence, 4. Method: Of 191 professional pitchers who attended our clinic between January 2009 and October 2018, 52 individuals had partial-thickness tears with at least 2 years of follow-up magnetic resonance imaging (MRI) scans and were included in this study. All initial MRI examinations were performed when a season was finished or during the off-season for regular medical check-up purposes. Hence, any abnormal finding on MRI, which suggests damage to the rotator cuff tendon, was assumed to have occurred during the previous season. The mean follow-up MRI period was 40.8 months (range, 24.4-100.9 months). We defined the year before an athlete’s first MRI at our clinic as the year of damage, and we evaluated athletic performance during the season before the damage (pre-damage year 1), the season of the damage (damage year), and 1 and 2 seasons after the damage (post-damage years 1 and 2). We evaluated the changes in 5 statistical performance indicators: earned run average (ERA), fielding independent pitching (FIP), walks plus hits divided by innings pitched (WHIP), winning percentage (WPCT), and innings pitched (IP). Results: The partial-thickness tears progressed in 39 of 52 (75%) patients. Of these 39 patients, 34 (87%) were grade 1 in severity and 5 (12.8%) were grade 2 or higher. The ERA of the pitchers did not increase significantly immediately after damage or at post-damage years 1 and 2. WPCT increased significantly compared with pre-damage year 1 ( P < .001), and IP decreased significantly during the follow-up period ( P < .001). Although no significant decrease in pitching ability was noted based on these 3 indices, significant increases were observed for FIP and WHIP. Conclusion: A partial-thickness rotator cuff tear does not have significant influence on the athletic performance of professional baseball pitchers in the short term based on conventional performance indicators. Our findings suggest that WHIP and IP decline significantly at 2 years after damage is noticed.
Bone–Patellar Tendon–Bone Autografts Versus Hamstring Autografts Using the Same Suspensory Fixations in ACL Reconstruction: A Systematic Review and Meta-analysis
Authors: Chen Wenbo , Li Hong , Chen Yuzhou , Jiang Fangyi , Wu Yang , Chen Shiyi 
Published: November 2019

Background: Bone–patellar tendon–bone (BPB) autografts and hamstring tendon (HT) autografts are 2 popular choices for anterior cruciate ligament reconstruction (ACLR). Although existing meta-analyses have explored the clinical outcomes between BPB and HT autografts, none have based their analysis on studies with just femoral suspensory fixation methods. Purpose: To evaluate and compare clinical outcomes, particularly graft failure and knee stability, of ACLR with BPB or HT autografts with suspensory femoral fixation. Study Design: Systematic review; Level of evidence, 4. Methods: A literature search was conducted of studies reporting single-bundle ACLR with BPB autografts and HT autografts with suspensory fixation with a minimum 24-month follow-up. Graft failure rate, knee stability, and clinical outcomes were compared for BPB versus HT autografts. Knee stability was measured with the Lachman test, pivot-shift test, and KT-1000/2000 arthrometer side-to-side difference (SSD). Clinical outcomes were measured with Lysholm scores and the Tegner activity scale, as well as rate of return to preinjury sports. Donor site morbidity among included studies was reviewed. A random-effects model was used for calculations of summary estimates. Subgroup, sensitivity, and trial sequential analyses were conducted. Results: Five studies were included. Graft failure was seen more often in the HT group than the BPB group, and this was statistically significant ( P = .03). However, the trial sequential analysis outcome indicated that the included sample size was not large enough to support a solid positive finding. The analysis showed no significant difference in SSD, Lachman test, pivot-shift test, rate of return to sports, Lysholm score, or Tegner score between groups. Subgroup analyses found no significant difference between groups. Conclusion: This meta-analysis demonstrated no significant differences in knee stability and knee functional outcomes between BPB and HT autografts with suspensory fixation. More evidence is needed to prove the lower risk of failure with use of BTB autograft with suspensory fixation.
Prevalence of Asymptomatic Intra-articular Changes of the Knee in Adult Professional Soccer Players
Authors: Bezuglov Eduard Nikolayevich , Lyubushkina Anastasiya Vladimirovna , Khaitin Vladimir Yurevich , Tokareva Alisa Viktorovna , Goncharov Evgeny Nikolayevich , Gorinov Artem Valerievich , Sivakova Elena Yurevna , Sereda Andrey Petrovitch 
Published: November 2019

Background: Currently, there are few data on the association between participation in soccer and the condition of the knee joints in adult professional players. Hypothesis: A high percentage of professional soccer players will have asymptomatic intra-articular changes of the knee. Study Design: Cross-sectional study; Level of evidence, 3. Methods: The condition of the intra-articular structures (osteophytes, cartilage, and menisci) in 94 knee joints of 47 adult professional soccer players (mean ± SD age, 25.7 ± 4.6 years; body mass index, 22.8 ± 1.4 kg/m2) was analyzed. A 1.5-T magnetic resonance imaging scanner was used to perform the imaging, and the anonymized data were analyzed by 2 experienced radiologists. Results: Cartilage of both knee joints was affected in 97.9% of soccer players. Meniscal lesions were detected in 97.8% of joints, affecting both joints in 93.6% of athletes. Grade 2 cartilage lesions were the most prevalent (36%-60% depending on the lesion site), and grade 4 lesions were detected in 12.7% of joints. The medial femoral condyle and medial tibial plateau were most frequently affected by cartilage lesions (85.1%). Among meniscal lesions, grade 2 lesions were the most prevalent, being detected in 71% of the cases. Grade 3 lesions were detected in 13.8% of the joints. The posterior horn of the lateral meniscus was the most common site of meniscal lesions (affected in 95.7% of the joints). Osteophytes were detected in 4.2% of joints. Conclusion: The prevalence of asymptomatic cartilage and meniscal lesions in the knees of adult professional soccer players is extremely high and is not associated with the reduction of sports involvement. This research should promote the correct interpretation of magnetic resonance imaging data obtained from soccer players with acute trauma and the reduction of the number of unwarranted surgical procedures.
Anatomy and Biomechanic of the Shoulder
Authors: Panjaitan Troydimas 
Published: November 2019

The shoulder is one of the most complex joints of the human body. Consequently, they are susceptible to injury and degeneration. Mechanical shoulder pathology typically results when overuse, extremes of motion, or excessive forces overwhelm intrinsic material properties of the shoulder complex resulting in tears of the rotator cuff, capsule, and labrum. The fundamental central component of the shoulder complex is the glenohumeral joint. It has a ball-and-socket configuration with a surface area ratio of the humeral head to glenoid fossa of about 3:1 with an appearance similar to a golf ball on a tee. Overall, there is minimal bony covering and limited contact areas that allow extensive translational and rotational ability in all three planes. The glenohumeral joint has 2 groups of stabilizers, which are static (passive) and dynamic (active) restrains. Static stabilizers include the concavity of the glenoid fossa, glenoid fossa retroversion and superior angulation, glenoid labrum, the joint capsule, and glenohumeral ligaments, and a vacuum effect from negative intra-articular pressure. Dynamic stabilization is merely the coordinated contraction of the rotator cuff muscles that create forces that compress the articular surfaces of the humeral head into the concave surface of the glenoid fossa. During upper extremity movement, the effects of static stabilizers are minimized and dynamic or active stabilizers become the dominant forces responsible for glenohumeral stability The simple act of arm elevation is a complex task that occurs via the combination of glenohumeral and scapulothoracic motion, together known as scapulohumeral rhythm. In the first 1200, glenohumeral arm abduction, the supraspinatus and deltoid work together and create a force couple that promotes stability, while raising the arm (deltoid contraction). In addition, the humerus must undergo 450 external rotation to not only clear the greater tuberosity posteriorly but also loosen the inferior glenohumeral ligament (IGHL) to allow maximum elevation. There are several anatomical updates regarding the rotator cuff and capsular footprint. The footprint of the supraspinatus on the greater tuberosity is much smaller than previously believed, and this area of the greater tuberosity is actually occupied by a substantial amount of the infraspinatus. The superior-most insertion of the subscapularis tendon extends a thin tendinous slip, which attaches to the fovea capitis of the humerus. The teres minor muscle inserts to the lowest impression of the greater tuberosity of the humerus and additionally inserts to the posterior side of the surgical neck of the humerus.
Functional Outcome Oxford Shoulder Score After Modified Weaver Dunn Technique Reconstruction in Patients with Acromioclavicular Injuries
Authors: Hendra  , Nasution Nino , Andriandi  
Published: November 2019

Objectives: This study aimed to compare the clinical outcome of the Oxford Shoulder Score in patients with acromioclavicular injuries that were operated with Modified Weaver Dunn Technique Reconstruction compared with the healthy side. Methods: A total of 8 patients with acromioclavicular injuries from 2011 until 2019 that were included in the study that were treated with the Modified Weaver Dunn Technique. Age, gender, range of motion and OSS score that was followed for a minimum of 6 months after surgery (Oxford Shoulder Score [OSS]) were recorded. Results: Patients’ gender characteristics totaled three females (3) and five males (5). There weren’t significant differences with regard to the OSS at minimum six months prior to surgery (p<0,05) with OSS score of joints that were treated with Modified Weaver Dunn Technique (44 ± 1,309) compared to healthy side (46,88 ± 0,835), range of motion forward flexion (169,63±0,835) and healthy side (177,88±2,1), extension (50±2,673) and healthy side (58,25±2,188), abduction (169,38±3623) and healthy side (178,±2,070), internal rotation (58,63±2,326) and healthy side (63,36±4,173), and also external rotation (49,38±3,204) and healthy side (56,88±3,720). Conclusion: Modified Weaver Dunn Reconstruction Technique can give good functional outcome and has no differences with the healthy side.
Platelet-Rich Plasma and Osteoarthritis of the Knee: A Literature Review
Authors: Rosandi Monica Elizabeth Tanod 
Published: November 2019

Osteoarthritis (OA) is a debilitating disease affecting people worldwide that affects weight-bearing joints, including the knee. Pharmacological options should be attempted before surgical therapy, especially for the younger population where there is a likelihood of residual symptoms and risk of revision post-surgery. There are several injection therapies available to treat symptoms and slow degenerative process. One option is platelet-rich plasma (PRP). The study aims to answer the following questions: What effect does PRP have on osteoarthritic chondrocytes? What are the current results on the clinical outcomes of PRP on knee OA? A search was conducted on Google Scholar and PubMed to find studies from the past five years on “knee osteoarthritis” and ”platelet-rich plasma”. Results from current findings demonstrate that PRP induces chondroprotection in vitro. Clinically, PRP improves short-term outcomes of symptomatic knee OA. Although the results look promising; unfortunately, a standardized PRP protocol has not been established and several studies are biased, thus the efficacy of PRP is still inconclusive.
Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL.
Authors: Laurent Camille , Nicolae Alina , Laurent Cécile , Le Bras Fabien , Haioun Corinne , Fataccioli Virginie , Amara Nadia , Adélaïde José , Guille Arnaud , Schiano Jean-Marc , Tesson Bruno , Traverse-Glehen Alexandra , Chenard Marie-Pierre , Mescam Lénaïg , Moreau Anne , Chassagne-Clement Catherine , Somja Joan , Escudié Fréderic , André Marc , Martin Nadine , Lacroix Laetitia , Lemonnier François , Hamy Anne-Sophie , Reyal Fabien , Bannier Marie , Oberic Lucie , Prade Nais , Frénois François-Xavier , Beldi-Ferchiou Asma , Delfau-Larue Marie-Helene , Bouabdallah Reda , Birnbaum Daniel , Brousset Pierre , Xerri Luc , Gaulard Philippe 
Published: November 2019

Key Points
An accumulation of alterations in epigenetic modifiers and genes in the JAK/STAT pathway likely drives BI-ALCL oncogenesis. Whole exome sequencing of a large series of BI-ALCL demonstrates recurrent mutations in epigenetic regulators.
Present Status and Prospect of High-Frequency Electro-hydraulic Vibration Control Technology
Authors: Liu Yi , Wang Tao , Gong Guofang , Gao Rujun 
Published: November 2019

AbstractElectro-hydraulic vibration equipment (EHVE) is widely used in vibration environment simulation tests, such as vehicles, weapons, ships, aerospace, nuclear industries and seismic waves replication, etc., due to its large output power, displacement and thrust, as well as good workload adaptation and multi-controllable parameters. Based on the domestic and overseas development of high-frequency EHVE, dividing them into servo-valve controlled vibration equipment and rotary-valve controlled vibration equipment. The research status and progress of high-frequency electro-hydraulic vibration control technology (EHVCT) are discussed, from the perspective of vibration waveform control and vibration controller. The problems of current electro-hydraulic vibration system bandwidth and waveform distortion control, stability control, offset control and complex vibration waveform generation in high-frequency vibration conditions are pointed out. Combining the existing rotary-valve controlled high-frequency electro-hydraulic vibration method, a new twin-valve independently controlled high-frequency electro-hydraulic vibration method is proposed to break through the limitations of current electro-hydraulic vibration technology in terms of system frequency bandwidth and waveform distortion. The new method can realize independent adjustment and control of vibration waveform frequency, amplitude and offset under high-frequency vibration conditions, and provide a new idea for accurate simulation of high-frequency vibration waveform.
Deep gene selection method to select genes from microarray datasets for cancer classification
Authors: Alanni Russul , Hou Jingyu , Azzawi Hasseeb , Xiang Yong 
Published: November 2019

Abstract
Background
Microarray datasets consist of complex and high-dimensional samples and genes, and generally the number of samples is much smaller than the number of genes. Due to this data imbalance, gene selection is a demanding task for microarray expression data analysis.

Results
The gene set selected by DGS has shown its superior performances in cancer classification. DGS has a high capability of reducing the number of genes in the original microarray datasets. The experimental comparisons with other representative and state-of-the-art gene selection methods also showed that DGS achieved the best performance in terms of the number of selected genes, classification accuracy, and computational cost.

Conclusions
We provide an efficient gene selection algorithm can select relevant genes which are significantly sensitive to the samples’ classes. With the few discriminative genes and less cost time by the proposed algorithm achieved much high prediction accuracy on several public microarray data, which in turn verifies the efficiency and effectiveness of the proposed gene selection method.
Polysaccharide biosynthetic pathway profiling and putative gene mining of Dendrobium moniliforme using RNA-Seq in different tissues
Authors: Yuan Yingdan , Zhang Jinchi , Kallman Justin , Liu Xin , Meng Miaojing , Lin Jie 
Published: November 2019

Abstract
Background
Dendrobium moniliforme (Linnaeus) Swartz is a well-known plant used in traditional Chinese medicine due to bioactive constituents. Polysaccharides are the main medicinal ingredients, yet no studies have been published on polysaccharide biosynthesis in D. moniliforme. To comprehensively investigate the polysaccharide at the transcription level, we performed de novo transcriptome sequencing for the first time to produce a comprehensive transcriptome of D. moniliforme.

Results
In our study, a database of 562,580 unigenes (average length = 1115.67 bases) was generated by performing transcriptome sequencing. Based on the gene annotation of the transcriptome, we identified 1204 carbohydrate-active related unigenes against CAZy database, including 417 glycosyltransferase genes (GTs), 780 glycoside hydrolases (GHs), 19 carbohydrate esterases (CEs), 75 carbohydrate-binding modules (CBMs), and 44 polysaccharide lyases (PLs). In the cellulose synthase family, 21 differential expression genes (DEGs) related to polysaccharide were identified. Subsequently, the tissue-specific expression patterns of the genes involved in polysaccharide pathway were investigated, which provide understanding of the biosynthesis and regulation of DMP at the molecular level. The two key enzyme genes (Susy and SPS) involved in the polysaccharide pathway were identified, and their expression patterns in different tissues were further analyzed using quantitative real-time PCR.

Conclusions
We determined the content of polysaccharides from Dendrobium moniliforme under different tissues, and we obtained a large number of differential genes by transcriptome sequencing. This database provides a pool of candidate genes involved in biosynthesis of polysaccharides in D. moniliforme. Furthermore, the comprehensive analysis and characterization of the significant pathways are expected to give a better insight regarding the diversity of chemical composition, synthetic characteristics, and the regulatory mechanism which operate in this medical herb.