bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mit der Modellkette RCP-GCM-RCM-mGROWA projizierte Grundwasserneubildung als Datenbasis für zukünftiges Grundwassermanagement in Nordrhein-Westfalen
Authors: Herrmann Frank , Keuler Klaus , Wolters Tim , Bergmann Sabine , Eisele Michael , Wendland Frank 
Published: January 2021

ZusammenfassungMit einem Multi-Modell-Ensemble wurde analysiert, wie sich der Klimawandel auf den Grundwasserhaushalt in Nordrhein-Westfalen (NRW) auswirkt. Hierzu wurden Projektionen der zukünftigen Grundwasserneubildung für insgesamt 36 Mitglieder der Modellkette RCP-GCM-RCM-mGROWA, bestehend aus 3 RCP-Szenarien zukünftiger globaler Erwärmung, 6 globalen und 5 dynamischen regionalen Klimamodellen sowie dem Wasserhaushaltsmodell mGROWA, vorgenommen. Mit dem Ensemble wurden für die hydrogeologischen Großräume NRWs nur teilweise signifikante Änderungen der jährlichen Grundwasserneubildung in den Perioden 2011–2040, 2041–2070 und 2071–2100 projiziert. Ein Robustheitstest mit zwei Kriterien (Übereinstimmung und Signifikanz der Änderungssignale) liefert keine belastbare Begründung dafür, dass sich die Grundwasserneubildung bis 2100 systematisch und signifikant ändern wird. Aus statistischer Perspektive wird deshalb die Schlussfolgerung gezogen, dass in NRW langfristig eine Grundwasserneubildung erwartet werden kann, die sich nicht grundlegend vom Niveau der Periode 1971–2000 unterscheidet. Hydro-meteorologisch befindet sich NRW in einer Übergangszone, in der eine Zunahme der Winterniederschläge die Wirkung der Erwärmung auf die Grundwasserneubildung wahrscheinlich kompensiert.
Forest multifunctionality is not resilient to intensive forestry
Authors: Pohjanmies Tähti , Eyvindson Kyle , Triviño María , Bengtsson Jan , Mönkkönen Mikko 
Published: January 2021

AbstractThere is ample evidence that intensive management of ecosystems causes declines in biodiversity as well as in multiple ecosystem services, i.e., in multifunctionality. However, less is known about the permanence and reversibility of these responses. To gain insight into whether multifunctionality can be sustained under intensive management, we developed a framework building on the concept of resilience: a system’s ability to avoid displacement and to return or transform to a desired state. We applied it to test the ability of forest multifunctionality to persist during and recover from intensive management for timber production in a boreal forest. Using forest growth simulations and multiobjective optimization, we created alternative future paths where the forest was managed for maximal timber production, for forest multifunctionality, or first maximal timber production and then multifunctionality. We show that forest multifunctionality is substantially diminished under intensive forestry and recovers the slower, the longer intensive forestry has been continued. Intensive forestry thus not only reduces forest multifunctionality but hinders its recovery should management goals change, i.e., weakens its resilience. The results suggest a need to adjust ecosystem management according to long-term sustainability goals already today.
Epigenetic modulation of immunotherapy and implications in head and neck cancer
Authors: Zhou Liye , Xu Na , Shibata Hirofumi , Saloura Vassiliki , Uppaluri Ravindra 
Published: January 2021

AbstractCancer progression is facilitated by distinct mechanisms developed by cancer cells to avoid immune recognition and clearance. The clinical application of immune checkpoint blockade (ICB), via monoclonal antibodies blocking PD-1/PD-L1 and CTLA4, has achieved promising durable therapeutic response in various cancer types, including recurrent and metastatic head and neck squamous cell carcinomas (HNSCC). HNSCC represents a rational target of ICB treatment given its relatively high mutation burden and the presence of immune infiltrates. However, the limited response rates and recent negative clinical trials data identify an urgent need for new strategies to overcome immunotherapy resistance. Preclinical studies have revealed an important contribution of epigenetic regulators in the anti-tumor immune response. Multiple components of the tumor and host immune system interaction are under epigenetic regulation, including the cancer cells themselves, cytotoxic T lymphocytes, regulatory T lymphocytes, natural killer cells, and tumor-associated macrophages. Epigenetic targeting drugs such as DNA methyltransferase inhibitors, histone deacetylase, and methyltransferase inhibitors have demonstrated the potential to reverse immune suppression in various cancer models. The aim of this review is to summarize recent preclinical studies focused on investigating the function of epigenetic modulation in the host immune and cancer cell interface. We also provide a perspective on combining epigenetic modulation and immunotherapy in the management of HNSCC to improve outcomes—an area of great interest in future clinical studies.
Concurrent Akt, ERK1/2 and AMPK Activation by Obestatin Inhibits Apoptotic Signaling Cascades on Nutrient-Deprived PC12 Cells
Authors: Sánchez-Temprano Agustín , Relova José Luis , Camiña Jesús P. , Pazos Yolanda 
Published: January 2021

AbstractTargeting apoptosis in the ischemic penumbra is a rational therapeutic approach for restricting cerebral infarct volume after clinical stroke. The present work explored the capability of the obestatin peptide, as a novel approach to inhibit apoptotic signaling cascades on PC12 cells. According to the results, obestatin treatment significantly reduced nutrient deprivation-induced apoptotic cell death. The protective effects were related to the regulation of the anti-apoptotic protein, BCL-2, and the apoptotic protein caspase-3. This encompasses the control of apoptosis by the interplay between Akt, ERK1/2 and AMPK signaling pathways. The activation of Akt and AMPK was concomitant with the phosphorylation of their downstream targets, GSK3 and ACC, respectively. Besides, obestatin also causes FoxO1 nuclear export supporting the prevention of the apoptosome formation. The concurrent activation of Akt and AMPK by obestatin via the GPR39 receptor, supports a role for this system in the balance concerning the catabolic and the anabolic signaling to sustain cellular function and viability. Furthermore, these results provide both an insight into how the obestatin/GPR39 system regulates anti-apoptotic pathways, and a framework for ascertaining how this system can be optimally targeted in treatment of brain cell death after stroke.
Identification and pathogenicity of Fusarium spp. associated with tuber dry rot and wilt of potato in Algeria
Authors: Azil Nadia , Stefańczyk Emil , Sobkowiak Sylwester , Chihat Saliha , Boureghda Houda , Śliwka Jadwiga 
Published: January 2021

AbstractFusarium is one of the most important genera of phytopathogenic fungi, causing potato wilt in the field and potato tuber dry rot during storage. The objectives of this study were to identify Fusarium species associated with both potato diseases in different growing regions in Algeria, and to assess their pathogenicity. Among the 152 isolates collected from symptomatic potato plants and tubers in different provinces in Algeria, 13 species of Fusarium and Neocosmospora were identified. Among these three species were isolated only from plants showing symptoms of Fusarium potato wilt (F. oxysporum, F. venenatum, Neocosmospora solani). Two species (F. culmorum, N. tonkinensis) and an isolate of Neocosmospora sp. were found exclusively in tubers with potato dry rot and the remaining ones (F. redolens, F. cf. tricinctum, F. sambucinum, F. cf. incarnatum-equiseti, F. nygamai, F. brachygibbosum and N. falciformis) were associated with both sample types. Fusarium sambucinum was the most frequent species (52.6% of isolates). Fusarium oxysporum and F. nygamai isolates were the most aggressive in the potato wilt pathogenicity test, and F. sambucinum isolates were the most aggressive in the potato tuber pathogenicity test. This is the first study identifying and characterizing potato dry rot and potato wilt pathogens in Algeria.
Safety aspects of the PiCCO thermodilution-cardiac output catheter during magnetic resonance imaging at 3 Tesla
Authors: Voet Marieke , Overduin Christiaan G. , Stille Ernst L. , Fütterer Jurgen J. , Lemson Joris 
Published: January 2021

AbstractThermodilution cardiac output monitoring, using a thermistor-tipped intravascular catheter, is used in critically ill patients to guide hemodynamic therapy. Often, these patients also need magnetic resonance imaging (MRI) for diagnostic or prognostic reasons. As thermodilution catheters contain metal, they are considered MRI-unsafe and advised to be removed prior to investigation. However, removal and replacement of the catheter carries risks of bleeding, perforation and infection. This research is an in vitro safety assessment of the PiCCO™ thermodilution catheter during 3 T Magnetic Resonance Imaging (3T-MRI). In a 3T-MRI environment, three different PiCCO™ catheter sizes were investigated in an agarose-gel, tissue mimicking phantom. Two temperature probes measured radiofrequency-induced heating; one at the catheter tip and one at a reference point. Magnetically induced catheter dislocation was assessed by visual observation as well as by analysis of the tomographic images. For all tested catheters, the highest measured temperature increase was 0.2 °C at the center of the bore and 0.3 °C under “worst-case” setting for the tested MRI pulse sequences. No magnetically induced catheter displacements were observed. Under the tested circumstances, no heating or dislocation of the PiCCO™ catheter was observed in a tissue mimicking phantom during 3T-MRI. Leaving the catheter in the critically ill patient during MRI investigation might pose a lower risk of complications than catheter removal and replacement.
Association of differentially expressed R-gene candidates with leaf spot resistance in peanut (Arachis hypogaea L.)
Authors: Dang Phat M. , Lamb Marshall C. , Chen Charles Y. 
Published: January 2021

AbstractEarly leaf spot (ELS) and late leaf spot (LLS) are major fungal diseases of peanut that can severely reduce yield and quality. Development of acceptable genetic resistance has been difficult due to a strong environmental component and many major and minor QTLs. Resistance genes (R-genes) are an important component of plant immune system and have been identified in peanut. Association of specific R-genes to leaf spot resistance will provide molecular targets for marker-assisted breeding strategies. In this study, advanced breeding lines from different pedigrees were evaluated for leaf spot resistance and 76 candidate R-genes expression study was applied to susceptible and resistant lines. Thirty-six R-genes were differentially expressed and significantly correlated with resistant lines, of which a majority are receptor like kinases (RLKs) and receptor like proteins (RLPs) that sense the presence of pathogen at the cell surface and initiate protection response. The largest group was receptor-like cytoplasmic kinases (RLCKs) VII that are involved in pattern-triggered kinase signaling resulting in the production reactive oxygen species (ROS). Four R-genes were homologous to TMV resistant protein N which has shown to confer resistance against tobacco mosaic virus (TMV). When mapped to peanut genomes, 36 R-genes were represented in most chromosomes except for A09 and B09. Low levels of gene-expression in resistant lines suggest expression is tightly controlled to balance the cost of R-gene expression to plant productively. Identification and association of R-genes involved in leaf spot resistance will facilitate genetic selection of leaf spot resistant lines with good agronomic traits.
Object Reconstruction Based on Attentive Recurrent Network from Single and Multiple Images
Authors: Gao Zishu , Li En , Wang Zhe , Yang Guodong , Lu Jiwu , Ouyang Bo , Xu Dawei , Liang Zize 
Published: January 2021

AbstractThe application of traditional 3D reconstruction methods such as structure-from-motion and simultaneous localization and mapping are typically limited by illumination conditions, surface textures, and wide baseline viewpoints in the field of robotics. To solve this problem, many researchers have applied learning-based methods with convolutional neural network architectures. However, simply utilizing convolutional neural networks without taking other measures into account is computationally intensive, and the results are not satisfying. In this study, to obtain the most informative images for reconstruction, we introduce a residual block to a 2D encoder for improved feature extraction, and propose an attentive latent unit that makes it possible to select the most informative image being fed into the network rather than choosing one at random. The recurrent visual attentive network is injected into the auto-encoder network using reinforcement learning. The recurrent visual attentive network pays more attention to useful images, and the agent will quickly predict the 3D volume. This model is evaluated based on both single- and multi-view reconstructions. The experiment results show that the recurrent visual attentive network increases prediction performance in a way that is superior to other alternative methods, and our model has desirable capacity for generalization.
Surrogate assisted interactive multiobjective optimization in energy system design of buildings
Authors: Aghaei Pour Pouya , Rodemann Tobias , Hakanen Jussi , Miettinen Kaisa 
Published: January 2021

AbstractIn this paper, we develop a novel evolutionary interactive method called interactive K-RVEA, which is suitable for computationally expensive problems. We use surrogate models to replace the original expensive objective functions to reduce the computation time. Typically, in interactive methods, a decision maker provides some preferences iteratively and the optimization algorithm narrows the search according to those preferences. However, working with surrogate models will introduce some inaccuracy to the preferences, and therefore, it would be desirable that the decision maker can work with the solutions that are evaluated with the original objective functions. Therefore, we propose a novel model management strategy to incorporate the decision maker’s preferences to select some of the solutions for both updating the surrogate models (to improve their accuracy) and to show them to the decision maker. Moreover, we solve a simulation-based computationally expensive optimization problem by finding an optimal configuration for an energy system of a heterogeneous business building complex. We demonstrate how a decision maker can interact with the method and how the most preferred solution is chosen. Finally, we compare our method with another interactive method, which does not have any model management strategy, and shows how our model management strategy can help the algorithm to follow the decision maker’s preferences.
Exploring Student Reasoning and Representation Construction in School Science Through the Lenses of Social Semiotics and Interaction Analysis
Authors: Knain Erik , Fredlund Tobias , Furberg Anniken 
Published: January 2021

AbstractThe meaning-making practices of science are multimodal and include representational forms such as spoken and written language, diagrams, graphs, equations, and images. Science learning proceeds through an ever-increasing grasp of such resources. This study aims at providing insight into how a combination of Interaction Analysis (IA) and social semiotic analysis can provide a deeper understanding of students’ engagement and learning with science representations. Social semiotics offers an analytical lens and categories for interpreting nuances of meaning in the visual domain. IA places a strong methodological emphasis on grounding analysis in unfolding interactions among peers, teachers, and artefacts. Investigating a teaching design where students iteratively produce multimodal drawings of the greenhouse effect, we used a multimodal analysis of the students’ drawings and an IA of transcribed video recordings of students’ interactions with each other and their teacher. The analyses show a progression towards more scientific student drawings over the course of a lesson. This progression was made possible by sustained attention to critical details in the drawings, and the drawings and interactions were instrumental in developing a more sophisticated understanding of the mechanisms behind the greenhouse effect. IA provides important analytical insights into students’ interest in the situation, which is at the heart of social semiotics. Social semiotics offers insight into the nuances of students’ interpretations of the world and how they relate to the practices of disciplinary science.
Contextual Effects on the Gendered Division of Housework: A Cross-Country and Cross-Time Analysis
Authors: Mandel Hadas , Lazarus Amit 
Published: January 2021

AbstractIndividuals who espouse an egalitarian gender ideology as well as economically independent women benefit from a more egalitarian division of housework. Although these two individual-level characteristics affect the gender division of housework, each suggests a different mechanism; the former is anchored within an economic logic and the latter within a cultural one. Using data of 25 countries from the 2002 and 2012 “Family and Changing Gender Roles” modules of the International Social Survey Program, we examine whether a country’s mean gender ideology and women’s labor force participation (WLFP) rate have a distinct contextual effect beyond these individual-level effects. We predict that the division of housework between married or cohabitating partners will be more egalitarian in countries with higher WLFP rates and in countries with more egalitarian attitudes, even after controlling for the two variables at the individual level. Given the cross-country convergence in WLFP, but not in gender ideology, we expect the effect of WLFP to decline over time and the effect of gender ideology to remain salient. Indeed, our multi-level analysis indicates that the net effect of WLFP, which was evident in 2002, had disappeared by 2012. By contrast, the net contextual effect of gender ideology, which was not significant in 2002, had become an important determinant of housework division by 2012. We conclude that further changes will depend on a country’s prevalent gender ideology because the equalizing effect of WLFP on the division of housework may have reached its limit.
What is the Prevalence of Low Health Literacy in European Union Member States? A Systematic Review and Meta-analysis
Authors: Baccolini V. , Rosso A. , Di Paolo C. , Isonne C. , Salerno C. , Migliara G. , Prencipe G. P. , Massimi A. , Marzuillo C. , De Vito C. , Villari P. , Romano F. 
Published: January 2021

Abstract
Background
Many studies have shown that low health literacy (HL) is associated with several adverse outcomes. In this study, we systematically reviewed the prevalence of low HL in Europe.

Methods
PubMed, Embase, and Scopus were searched. Cross-sectional studies conducted in the European Union (EU), published from 2000, investigating the prevalence of low HL in adults using a reliable tool, were included. Quality was assessed with the Newcastle-Ottawa Scale. Inverse-variance random effects methods were used to produce pooled prevalence estimates. A meta-regression analysis was performed to assess the association between low HL and the characteristics of the studies.

Results
The pooled prevalence of low HL ranged from of 27% (95% CI: 18–38%) to 48% (95% CI: 41–55%), depending on the literacy assessment method applied. Southern, Western, and Eastern EU countries had lower HL compared to northern Europe (β: 0.87, 95% CI: 0.40–1.35; β: 0.59, 95% CI: 0.25–0.93; and β: 0.72, 95% CI: 0.06–1.37, respectively). The assessment method significantly influenced the pooled estimate: compared to word recognition items, using self-reported comprehensions items (β: 0.61, 95% CI: 0.15–1.08), reading or numeracy comprehensions items (β: 0.77, 95% CI: 0.24–1.31), or a mixed method (β: 0.66, 95% CI: 0.01–1.33) found higher rates of low HL. Refugees had the lowest HL (β: 1.59, 95% CI: 0.26–2.92). Finally, lower quality studies reported higher rates of low HL (β: 0.56, 95% CI: 0.06–1.07).

Discussion
We found that low HL is a public health challenge throughout Europe, where one in every three to almost one in every two Europeans may not be able to understand essential health-related material. Additional research is needed to investigate the underlying causes and to develop remedies.

PROSPERO Registration
CRD42019133377
Mind-mindedness in out-of-home Care for Children: Implications for caregivers and child
Authors: Colonnesi Cristina , Konijn Carolien , Kroneman Leoniek , Lindauer Ramón J. L. , Stams Geert Jan J. M. 
Published: January 2021

AbstractMost out-of-home placed children have experienced early adversities, including maltreatment and neglect. A challenge for caregivers is to adequately interpret their foster child’s internal mental states and behavior. We examined caregivers’ mind-mindedness in out-of-home care, and the association among caregivers’ mind-mindedness (and its positive, neutral, and negative valence), recognition of the child’s trauma symptoms, and behavior problems. Participants (N = 138) were foster parents, family-home parents, and residential care workers. Caregivers’ mind-mindedness was assessed with the describe-your-child measure. Caregivers’ recognition of the child’s trauma symptoms, their child’s emotional symptoms, conduct problems, prosocial behavior, and quality of the caregiver-child relationship were assessed using caregivers’ reports. Foster parents produced more mental-state descriptors than did residential care workers. General mind-mindedness, as well as neutral and positive mind-mindedness, related negatively to conduct problems. Besides, positive mind-mindedness was associated with prosocial behavior and neutral mind-mindedness with a better quality of the caregiver-child relationship and fewer child conduct problems. Negative mind-mindedness related positively to the caregiver’s recognition of the child’s trauma symptoms, and indirectly, to emotional symptoms. In conclusion, mind-mindedness seems to be an essential characteristic of out-of-home caregivers, connected to the understanding of their child’s behavior problems and trauma symptoms, as well as to the relationship with the child. The findings suggest a possible use of mind-mindedness in out-of-home care evaluation and intervention.