bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dabigatran Treatment of Acute Noncardioembolic Ischemic Stroke
Authors: Butcher Ken S. , Ng Kelvin , Sheridan Patrick , Field Thalia S. , Coutts Shelagh B. , Siddiqui Muzzafar , Gioia Laura C. , Buck Brian , Hill Michael D. , Miller Jodi , Klahr Ana C. , Sivakumar Leka , Benavente Oscar R. , Hart Robert G. , Sharma Mike 
Published: March 2020

Background and Purpose—
Patients with transient ischemic attack (TIA) and minor ischemic stroke are at risk for early recurrent cerebral ischemia. Anticoagulants are associated with reduced recurrence but also increased hemorrhagic transformation (HT). The safety of the novel oral anticoagulant dabigatran in acute stroke has not been evaluated.

Methods—
DATAS II (Dabigatran Treatment of Acute Stroke II) was a phase II prospective, randomized open label, blinded end point trial. Patients with noncardioembolic stroke/transient ischemic attack (National Institutes of Health Stroke Scale score, ≤9; infarct volume, ≤25 mL) were randomized to dabigatran or aspirin. Magnetic resonance imaging was performed before randomization and repeated at day 30. Imaging end points were ascertained centrally by readers blinded to treatment. The primary end point was symptomatic HT within 37 days of randomization.

Results—

A total of 305 patients, mean age 66.59±13.21 years, were randomized to dabigatran or aspirin a mean of 42.00±17.31 hours after symptom onset. The qualifying event was a transient ischemic attack in 21%, and ischemic stroke in 79% of patients. Median National Institutes of Health Stroke Scale (interquartile range) was 1 (0–2), and mean infarct volume 3.2±6.5 mL. No symptomatic HT occurred. Asymptomatic petechial HT developed in 11/142 (7.8%) of dabigatran-assigned patients and 5/142 (3.5%) of aspirin-assigned patients (relative risk, 2.301 [95% CI, 0.778–6.802]). Baseline infarct volume predicted incident HT (odds ratio, 1.07 [95% CI, 1.03–1.12];
P
=0.0026). Incident covert infarcts on day 30 imaging occurred in 9/142 (6.3%) of dabigatran-assigned and 14/142 (9.8%) of aspirin-assigned patients (relative risk, 0.62 [95% CI, 0.26, 1.48]).

Conclusions—
Dabigatran was associated with a risk of HT similar to aspirin in acute minor noncardioembolic ischemic stroke/transient ischemic attack.

Registration—

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02295826.
Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome
Authors: Liu Li , Fuller Matthew , Behymer Tyler P. , Ng Yisi , Christianson Thomas , Shah Shreyansh , King Nicolas Kon Kam , Woo Daniel , James Michael L. 
Published: March 2020

Background and Purpose—
Selective serotonin reuptake inhibitors (SSRIs) have a well-established association with bleeding complications and conflicting reports on outcome after stroke. We sought to evaluate whether pre–intracerebral hemorrhage (ICH) SSRI use increased ICH risk and post-ICH SSRI use improved ICH outcome.

Methods—
Through post hoc analysis of the ERICH study (Ethnic/Racial Variations of Intracerebral Hemorrhage), SSRI use was categorized into no use, pre-ICH only, pre- and post-ICH use (termed “continuous”), and post-ICH only (termed “new”). Using multivariable modeling, associations were sought between pre-ICH SSRI use and ICH risk in the case-control set, and associations between post-ICH SSRI use and 3-month outcome were analyzed in the ICH case set. Exploratory analyses sought to assess influence of race/ethnicity in models.

Results—

The final study cohort consisted of 2287 ICH cases and 2895 controls. Pre-ICH SSRI use was not associated with ICH risk (odds ratio, 0.824 [95% CI, 0.632–1.074]) nor potentiation of ICH risk with anticoagulant or antiplatelet use. New post-ICH SSRI use was associated with unfavorable modified Rankin Scale score at 3 months after ICH (odds ratio, 1.673 [95% CI, 1.162–2.408];
P
=0.006) in multivariable analyses. Additional propensity score analysis indicated a similar trend but did not reach statistical significance (
P
=0.107). When stratified by race/ethnicity, multivariable modeling demonstrated reduced ICH risk with pre-ICH SSRI use in Hispanics (odds ratio, 0.513 [95% CI, 0.301–0.875];
P
=0.014), but not non-Hispanic whites or blacks, and no associations between post-ICH SSRI use and 3-month outcome in any racial/ethnic group.

Conclusions—
In a large multiethnic cohort, pre-ICH SSRI use was not associated with increased ICH risk, but post-ICH SSRI use was associated with unfavorable 3-month neurological outcome after ICH.

Registration—

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01202864.
SELECTION OF FUEL SUPPLIER FOR TRANSPORT FIRMS BY USING THE AHP
Authors: GÖRÇÜN Ömer Faruk 
Published: March 2020

Selection of proper fuel supplier is extremely important for companies that carry out transportation activities and it can be evaluated as a critical decision to obtain competitive advantages in the transportation market. A structural and systematic frame is suggested in this paper in order to solve the decision problems for fuel supplier selection. In order to determine the selection criteria, the board of experts was constructed and a large number of roundtable meetings that realized in the way of brainstorm were organized with them. One of the most important questions can be asked as what are the selection criteria and decision options for the fuel supplier selection process? Experts who are a decision maker in their companies tried to seek a rational answer to this question. At the end of these meetings, obtained results were re-evaluated by the members of the board and selection criteria and decision options that will use for evaluation process were determined. The decision alternatives are Brand-P, Brand-B, Brand-S, and Brand-O. The selection criteria can be sorted as: fuel price per liter, product quality, service quality, easy terms of payment, brand awareness, environmental sensitivity. Actually, selection of fuel and fuel supplier has an extremely complex characteristic and it is a multi-criteria decision-making problem. In this paper, the analytic hierarchy process theory was selected as a multi-criteria decision making problem in order to solve the decision making problem concerning with fuel and fuel supplier selection process. By using this methodology, decision makers can select the best fuel brand and fuel supplier by comparing variables such as selection criteria and decision alternatives in a mathematical model.
A Survey on Deep Learning for Multimodal Data Fusion
Authors: Gao Jing , Li Peng , Chen Zhikui , Zhang Jianing 
Published: March 2020

AbstractWith the wide deployments of heterogeneous networks, huge amounts of data with characteristics of high volume, high variety, high velocity, and high veracity are generated. These data, referred to multimodal big data, contain abundant intermodality and cross-modality information and pose vast challenges on traditional data fusion methods. In this review, we present some pioneering deep learning models to fuse these multimodal big data. With the increasing exploration of the multimodal big data, there are still some challenges to be addressed. Thus, this review presents a survey on deep learning for multimodal data fusion to provide readers, regardless of their original community, with the fundamentals of multimodal deep learning fusion method and to motivate new multimodal data fusion techniques of deep learning. Specifically, representative architectures that are widely used are summarized as fundamental to the understanding of multimodal deep learning. Then the current pioneering multimodal data fusion deep learning models are summarized. Finally, some challenges and future topics of multimodal data fusion deep learning models are described.
The Affinity between Alghazali’s Intentions of the Philosophers and Maimonides’ Philosophy, According to Shalom Anabi
Authors: Elior Ofer 
Published: March 2020

Abstract
Beginning in the late 13th century, readers of Alghazali’s Intentions of the Philosophers in the Provençal, Spanish and Italian Jewish spheres viewed this treatise as belonging to the same tradition to which the philosophical stances of Maimonides, or at least some of them, belong. Readers who espoused this view were sometimes also of the opinion that the Intentions was the direct source for Maimonides’ ideas. These views, coupled with an understanding that the tradition in question differs from the philosophical tradition whose representative is Averroes, led students of Maimonides’ philosophy to examine his stances on issues about which the two traditions were in dispute. The present Zuta shows that the same opinions and approaches were adopted and expressed by Shalom Anabi, one of the leading scholars of the Jewish intellectual community of Constantinople in the 15th century.
A Note on an Old Jewish Bibliotaphos
Authors: Rosenzweig Claudia 
Published: March 2020

Abstract
In the editio princeps of the Mayse-bukh (Basel 1602) are circa 250 stories. The last one is a translation/reworking of a story that appears in Sefer Hasidim, and is about a bibliotaphos, someone who is ready to bury his books, but not to lend them. In this short paper, I try to show the differences between the Yiddish and the Hebrew source, suggesting that these differences can hint at historical and social transformations of the reading public of Yiddish texts in the Early Modern era.
Computational Analysis of Historical Hebrew Newspapers: Proof of Concept
Authors: Soffer Oren , Segal Zef , Greidinger Nurit , Rusinek Sinai , Silber-Varod Vered 
Published: March 2020

Abstract
This article focuses on one decade, 1874–1883, in the relatively long lifespan of the Hebrew weekly Ha-Tzefirah, which was founded in Warsaw in 1862. Applying computational tools to the study of the early Hebrew press requires a unique effort. The Hebrew language in general is distinct in its characters, morphological structure, and word order. The contribution of this proof-of-concept study is two-fold: First, computational analysis provides a long-term indication of trends in the discourse that cannot be attained through qualitative study. The second contribution is on the micro level: Computational analysis can potentially shed light, in a diachronic perspective, on the use of a specific term or the discussion of a specific geographical location.
Long-Lead Predictions of Warm Season Droughts in South Korea Using North Atlantic SST
Authors: Myoung Boksoon , Rhee Jinyoung , Yoo Changhyun 
Published: March 2020

AbstractUnderstanding and predicting warm season (May–October) droughts is critically important in South Korea for agricultural productivity and water resource management. Using a 6-month standardized precipitation index ending in October (SPI6_Oct), we investigate the interannual variability of warm season droughts and the related large-scale atmospheric circulations for the most recent 20-yr period (1995–2014). Cyclonic (anticyclonic) circulations to the east of Japan (in the North Pacific) tend to induce warm season droughts (wetness) by suppressing (enhancing) moist water transport from the south of the Korean Peninsula. These circulation patterns to the east of Japan are linked to a barotropic Rossby wave–like teleconnection pattern from the North Atlantic to East Asia, which is found to be responsible for the interannual variability of SPI6_Oct. This teleconnection pattern is highly correlated with the difference in sea surface temperature (SST) between the Norwegian Sea and the Barents Sea (referred to as NA_dipole) in January–March (r = 0.68), which modulates the snow depth over the Ural Mountains in spring and the sea ice concentration over the Barents Sea during the entire warm season. Two drought prediction models, an empirical model and a hybrid machine learning model, are developed and tested for their predictive skills for South Korea. An empirical prediction model using NA_dipole as one of the predictors is found to accurately capture the interannual variability of SPI6_Oct (r2 = 53%). NA_dipole is found to improve the predictive skills of the hybrid machine learning drought prediction model, especially for longer lead times. Our results emphasize the significant role of North Atlantic SST anomalies in warm season medium-range droughts in South Korea.
The Effects of Recency and Numerical Uncertainty Estimates on Overcautiousness
Authors: Demnitz Raoni , Joslyn Susan 
Published: March 2020

AbstractThe four experiments reported here tested the impact of recent negative events on decision-making. Participants were given a virtual budget to spend on crops of varying costs and payoffs that, in some cases, depended on drought conditions. Participants made 46 decisions based on either deterministic or probabilistic seasonal climate predictions. Participants experienced a sequence of droughts either immediately prior to the target trials (recent condition) or early in the sequence (distant condition). In experiment 1, participants made overly cautious crop choices when droughts were experienced recently. Subsequent experiments probed the cognitive mechanisms involved. The effect of recency on overcautiousness was reduced by a midexperiment message, although it did not matter whether the message described a changed or consistent venue and time period. This suggests that overcautiousness was not caused by deducing a climatic trend in the particular area. Instead, we argue that availability—events that are easier to recall are judged to be more likely—was the major cause for increased cautiousness following recent droughts. Importantly, probabilistic predictions attenuated the impact of recency, inspired greater trust, and allowed participants to make better decisions overall than did deterministic predictions. Implications are discussed.
The effectiveness of an aerobic exercise training on patients with neck pain during a short- and long-term follow-up: a prospective double-blind randomized controlled trial
Authors: Daher Amira , Carel Rafael S , Tzipi Knoll , Esther Hazan , Dar Gali 
Published: March 2020

Objective: To examine the effect of adding aerobic exercise (AE) to neck-specific exercise treatment for patients with neck pain (NP) to reduce pain and disability. Design: A prospective multicentre randomized controlled trial. Setting: Physiotherapy outpatient clinics. Subjects: Patients with nonspecific NP. Intervention: Patients with NP were randomly assigned to six weeks of neck-specific exercise with and without the addition of AE. Measures: Patients were classified as having a successful or non-successful outcome according to the Global Rating of Change (GROC). Outcome measures included Visual Analogue Scale (VAS), Neck Disability Index (NDI), Fear Avoidance Beliefs Questionnaire (FABQ) and cervicogenic headache. Assessments were performed at six-week, and three- and six-month follow-ups. Results: A total of 139 participants (mean age: 54.6 ± 10.5 years) were recruited ( n = 69 AE, n = 70 control). According to GROC, 77.4% of the AE group reported a successful outcome at six months vs. 40% in the control group ( P < 0.001). There was a significant reduction in VAS from baseline to six months in the AE vs. control group 6.73 (±1.69) to 1.89 (±1.37) vs. 6.65 (±1.67) to 3.32 (±1.82), respectively ( P  < 0.001). Significant improvements were also obtained for NDI and FABQ from baseline to six weeks in the AE group: NDI from 16.10 (±4.53) to 7.78 (±4.78) vs. 17.01 (±4.84) to 11.09 (±5.64) in the control group ( P = 0.003); FABQ from 33.53 (±9.31) to 20.94 (±841) in the AE vs. 33.45 (±10.20) to 26.83 (±10.79) in the control group ( P < 0.001). The AE group also demonstrated significant reduction in cervicogenic headache from baseline to six months ( P = 0.003). Conclusion: Adding AE to long-term neck-specific exercises is an effective treatment for reducing NP and headache in patients with NP.
Ethical and research governance approval across Europe: Experiences from three European palliative care studies
Authors: Preston Nancy , van Delden Johannes JM , Ingravallo Francesca , Hughes Sean , Hasselaar Jeroen , van der Heide Agnes , Van den Block Lieve , Dunleavy Lesley , Groot Marieke , Csikos Agnes , Payne Sheila 
Published: March 2020

Background: Research requires high-quality ethical and governance scrutiny and approval. However, when research is conducted across different countries, this can cause challenges due to the differing ethico-legal framework requirements of ethical boards. There is no specific guidance for research which does not involve non-medicinal products. Aim: To describe and address differences in ethical and research governance procedures applied by research ethics committees for non-pharmaceutical palliative care studies including adult participants in collaborative European studies. Design: An online survey analysed using descriptive statistics. Setting/participants: Eighteen principal investigators in 11 countries conducting one of three European-funded studies. Results: There was variation in practice including whether ethical approval was required. The time to gain full approvals differed with the United Kingdom having governance procedures that took the longest time. Written consent was not required in all countries nor were data safety monitoring committees for trials. There were additional differences in relation to other data management issues. Conclusion: Researchers need to take the differences in research approval procedures into account when planning studies. Future research is needed to establish European-wide recommendations for policy and practice that dovetail ethical procedures and enhance transnational research collaborations.
Potential drug–drug Interactions in hospitalized cancer patients: A report from the Middle-East
Authors: Moghaddas Azadeh , Adib-Majlesi Mohammad , Sabzghabaee Ali M , Hajigholami Ali , Riechelmann Rachel 
Published: March 2020

Introduction Patients suffering from solid tumors use a wide range of cytotoxic drugs. In this study, we aimed to detect, document, and descriptively analyze the potential drug–drug interactions in hospitalized solid tumor’s patients in a Middle Eastern referral oncology–hematology University-affiliated hospital. Materials and methods In this cross-sectional study, the medical record of solid tumor’s patients who were admitted to the referral oncological center in Isfahan, Iran, during the six months period (2018) were considered. We included all patients who had received at least two chemotherapy or nonchemotherapy drugs simultaneously. The potential drug–drug interactions between chemotherapy and nonchemotherapy drugs were evaluated with Lexi-Interact ver.1.1 online software. Results During the study period, a total of 141 cancer patients were recruited, and their drug therapy regiment was thoroughly analyzed. We detected 227 drug–drug interactions with moderate or major severity out of included patients in which 96, 71, 32, and 28 interactions were in the category of C, D, B, and X, respectively. One hundred and fourteen patients (80.8%) encountered at least one potential drug–drug interactions during their hospitalization. Mechanistically, most of drug–drug interactions (56.4%) were pharmacodynamics. Interaction between granisetron and metoclopramide were the top 10 detected interaction (11.4%). The interaction between docetaxel and carboplatin was the most frequent drug–drug interactions between oncology drugs (2.6% of total drug–drug interactions). Conclusion Potentially moderate or major drug–drug interactions frequently occur among solid tumor’s cancer patients necessitate the establishment of a clinical pharmacy service for providing relevant pharmacotherapy consultations to prevent this potentially serious concern.
Religiosity, Psychological Resilience, and Mental Health Among Breast Cancer Patients in Kingdom of Saudi Arabia
Authors: Al Eid Nawal A , Alqahtani Mohammed MJ , Marwa Khaldoun , Arnout Boshra A , Alswailem Hajar S , Al Toaimi Al Anoud 
Published: March 2020

Objectives: This study aimed to investigate the correlations of religiosity and psychological resilience with mental health among cancer patients and to examine whether religiosity and psychological resilience can predict mental health. Method: The sample consisted of 329 patients. Researchers applied Islamic Religiosity Scale, Wagnild and Young Resilience Scale, and the scale of Hospital Anxiety and Depression. Results: The results showed that there are positive, statistically significant correlations between religiosity and psychological resilience, while there were negative, statistically significant correlations of religiosity and psychological resilience with mental health. And there are correlations between the alternative therapeutic interventions currently used to religiosity and psychological resilience, while there were no statistically significant correlations between alternative therapeutic interventions that the patient will use in the future to religiosity and psychological resilience. The results also revealed the possibility of predicting mental health through religiosity and psychological resilience. Conclusion: These results emphasized the importance of increased religiosity and psychological resilience among cancer patients.
Choices are inevitable: A qualitative exploration of the lifecosts of systemic lupus erythematosus
Authors: Dixon J , Cardwell FS , Clarke Ann E , Elliott SJ 
Published: March 2020

Objectives Individuals with systemic lupus erythematosus experience considerable economic challenges. The aim of this research is to qualitatively investigate experiences of the lifecosts (direct and indirect economic costs and beyond) to those with systemic lupus erythematosus in Canada. Methods Using a biopsychosocial conceptual framework and integrated knowledge translation approach, qualitative semi-structured interviews were conducted with 3 physicians, 5 representatives from systemic lupus erythematosus advocacy groups, and 29 adult systemic lupus erythematosus patients. Themes emerged deductively and inductively, and the theme code set was used to code all transcripts. Results Three dominant themes emerged: (1) impacts of systemic lupus erythematosus on quality of life, relationships, and health; (2) costs linked to healthcare; and (3) impacts of living with systemic lupus erythematosus on employment/economic standing. Discussion Whereas previous work has focused almost exclusively on the direct, individual costs of systemic lupus erythematosus, the biopsychosocial approach taken here emphasizes not only the individual and intermediate factors (such as the workplace and family), but also the system-level factors (i.e. system-level policies) that influence quality of life, healthcare, and employment/economic experiences of those with systemic lupus erythematosus. Results indicate a need to target interventions beyond the individual and their immediate context, and recognize that lifecosts are shaped significantly by systems-level action.