bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Computational Technique to Evaluate the Relative Influence of Internal and External Cooling on Overall Effectiveness
Authors: Bryant Carol E. , Rutledge James L. 
Published: January 2020

Abstract
Gas turbine components are protected via a coolant that travels through internal passageways before being ejected as external film cooling. Modern computational approaches facilitate the simulation of the conjugate heat transfer that takes place within turbine components, allowing the prediction of the actual metal temperature, nondimensionalized as overall effectiveness. Efforts aimed at improving cooling are often focused on either the internal cooling or the film cooling; however, the common coolant flow means that the internal and external cooling schemes are linked and the coolant holes themselves provide another convective path for heat transfer to the coolant. The relative influence of internal cooling, external cooling, and convection through the film cooling holes on overall effectiveness is not well understood. Computational fluid dynamics (CFD) simulations were performed to isolate each cooling mechanism, and thereby determine their relative contributions to overall effectiveness. The conjugate CFD model was a flat plate with five staggered rows of shaped film cooling holes. Unique boundary conditions were used to isolate the cooling mechanisms. The internal surface was modeled with and without heat transfer on the internal face in order to isolate the effects of plenum cooling. Convection through the coolant holes was isolated by making the inside of the film cooling holes adiabatic to evaluate the influence of the internal cooling provided by the cooling holes themselves. Finally, the effect of film cooling was removed through the novel use of an outlet boundary condition at the exit of each hole that allowed the internal coolant flow without external coolant ejection.
The small-slope approximation for layered, fluid seafloors
Authors: Jackson Darrell , Olson Derek R. 
Published: January 2020

ABSTRACT
The small-slope approximation (SSA) for rough-interface scattering is most commonly applied to the upper boundary of either impenetrable media or uniform half-space media, but has been recently developed for layered media in the acoustic and electromagnetic cases. The present work gives an overview of three forms of the SSA for layered media. The first has been previously presented in the acoustics literature. The second is from the electromagnetics literature and in the present work is converted to the fluid-sediment problem. A missing proof is supplied of a key consistency condition demanded of the small-slope ansatz. As is usual, these small-slope results are expressed in k-space. A third SSA for layered seafloors follows from conversion of the usual half-space formulation from k-space to coordinate space. This form turns out to be useful for reverberation simulations. The three different approaches are compared with respect to scattering strength and the coherent reflection coefficient, but an assessment of their relative merits will require comparison with exact calculations.
Myoelectric Responses of Lower-Body Muscles Performing Squat and Lunge Exercise Variations Adopting Visual Feedback With a Laser Sensor
Authors: Paz Gabriel Andrade , Almeida Lohanne , Ruiz Larissa , Casseres Sabrina , Xavier Giovanna , Lucas João , Santana Haroldo Gualter , Miranda Humberto , Bonnette Scott , Willardson Jeffrey 
Published: January 2020

Study design: Cross-over study. Context: The squat, single-leg squat, forward lunge, and reverse lunge are fundamental movements often performed in activities of daily living, sports competitions, and sport-specific training. Objective: The purpose of this study was to investigate the effect of visual feedback with a laser sensor (VFLS) versus a control condition on the myoelectric activity (surface electromyography [sEMG]) of the vastus medialis oblique (VMO), vastus lateralis, gluteus medius (Gmed), and erector spinae muscles during the performance of several squat variations with bodyweight. Methods: Nineteen female college students (20 [2.5] y, 165.3 [10.2] cm, 66.4 [4.1] kg, 2 [1.2] y of resistance training experience) with a background in strength or sports training volunteered to participate in this study. Over 4 separate visits, subjects performed 2 sets of 10 repetitions of a squat variation exercise in random order (ie, squat, single-leg squat, forward lunge, and reverse lunge). The first set of a given squat variation condition was considered a control set, and then after 3-minute rest, a second set was performed with VFLS. Results: Significant decreases in VMO and Gmed myoelectric activity were observed during the VFLS set versus the control set for the forward lunge exercise (P = .03). No differences were observed between the control set and VFLS set in the sEMG normalized signal for all muscles analyzed for the squat and single-leg squat, respectively. However, the sample entropy of the sEMG signal for the erector spinae became more irregular during the VFLS set versus the control set for the squat exercise (P = .01), whereas the Gmed presented a more irregular sEMG signal during the VFLS set versus the control set for the single-leg squat (P = .08). Conclusion: Laser sensor biofeedback may induce significant decreases in VMO and Gmed activation performing forward lunge exercise. Therefore, laser sensor biofeedback may induce a reduction in muscle activity of neutralizers muscles during a few squat bodyweight variations (bilateral, single-leg, forward, and reverse lunge).
High Levels of Serum Angiopoietin 2 and Angiopoietin 2/1 Ratio at the Critical Stage of Dengue Hemorrhagic Fever in Patients and Association with Clinical and Biochemical Parameters
Authors: Mapalagamage Maheshi , Handunnetti Shiroma M. , Wickremasinghe Ananda Rajitha , Premawansa Gayani , Thillainathan Sharmila , Fernando Tharanga , Kanapathippillai Karunayokiny , De Silva Aruna Dharshan , Premawansa Sunil 
Published: January 2020

Longitudinal changes of serum angiopoietin 1 (Ang-1) and angiopoietin 2 (Ang-2) associated with endothelial stability in dengue patients with different disease stages were studied. Serum Ang-1 and Ang-2 levels were measured in confirmed dengue fever (DF) patients on admission (DFA,
n
= 40) and discharge (DFD,
n
= 20); in dengue hemorrhagic fever (DHF) patients on admission (DHFA,
n
= 40), at critical stage (DHFC,
n
= 36), and on discharge (DHFD,
n
= 20); and in healthy controls (HC,
n
= 25).
Formation of the main sulfide zone at Unki Mine, Shurugwi Subchamber of the Great Dyke, Zimbabwe: Constraints from petrography and sulfide compositions
Authors: Chaumba Jeff B. , Musa Caston T. 
Published: January 2020

AbstractThe major platinum group element (PGE) occurrence in the Great Dyke of Zimbabwe, the main sulfide zone, is a tabular stratabound layer hosted in pyroxenites, and it is broadly similar in form throughout the length of the Great Dyke. We conducted a petrographic and sulfide composition study on a sulfide-enriched zone from the contact of the mafic sequence–ultramafic sequence through the main sulfide zone at Unki Mine in the Shurugwi Subchamber to its underlying footwall rocks to place some constraints on the origin of the rocks.Pyrrhotite, pentlandite, chalcopyrite, and pyrite are the base metal sulfides that were encountered during the study. Pyrrhotite, pentlandite, and chalcopyrite typically occurred as inclusions in both primary (orthopyroxene, plagioclase, and clinopyroxene) and secondary (amphibole and chlorite) silicate phases, whereas pyrite was observed in only three samples, where it occurred in association with pyrrhotite. The concentrations of PGEs in the base metal sulfides were nearly all at or below minimum detection limits. The intercumulus nature of some of these sulfides in the investigated sequence suggests that they were likely formed during the crystallization history of these rocks. The occurrence of pyrite, which we interpret to be an alteration phase, suggests that a late-stage event, likely formed during hydrothermal alteration, helped to concentrate the mineralization at Unki Mine. In some cases, however, these sulfides occur partially surrounding some chromite and silicate phases. Thus, some sulfides in the Unki Mine area were likely formed early in the crystallization history of the Great Dyke, whereas others were formed late during hydrothermal processes. Low concentrations of PGEs such as platinum (Pt), palladium (Pd), and rhodium (Rh) in base metal sulfides imply that the PGEs in the main sulfide zone and Unki Mine are hosted either in silicates and/or platinum group minerals. Very low Co contents in pentlandites in the rocks under investigation are interpreted to imply that very limited Fe substitution by Co, and also of Ni by Co, occurred. Broadly comparable trends, with minor variations of Fe in pyrrhotite, of Co and Ni in pentlandite, and of Cu in chalcopyrite, for example, likely reflect magmatic processes. The concentrations of these metals in base metal sulfides vary sympathetically, indicating that their original magmatic signatures were subsequently affected by hydrothermal fluids. The spiked pattern displayed by the variations in the percent modal proportions of the base metal sulfides across the entire investigated stratigraphic section is interpreted to reflect remobilization of the sulfides during hydrothermal alteration. Depletions in some elements, which occur near the base and at the top of the investigated succession, are likely a result of this hydrothermal alteration.
Dynamic models of earthquake rupture along branch faults of the eastern San Gorgonio Pass region in California using complex fault structure
Authors: Douilly Roby , Oglesby David D. , Cooke Michele L. , Hatch Jennifer L. 
Published: January 2020

AbstractGeologic data suggest that the Coachella Valley segment of the southern San Andreas fault (southern California, USA) is past its average recurrence time period. At its northern edge, this right-lateral fault segment branches into the Mission Creek and Banning strands of the San Andreas fault. Depending on how rupture propagates through this region, there is the possibility of a throughgoing rupture that could lead to the channeling of damaging seismic energy into the Los Angeles Basin. The fault structures and potential rupture scenarios on these two strands differ significantly, which highlights the need to determine which strand provides a more likely rupture path and the circumstances that control this rupture path. In this study, we examine the effect of different assumptions about fault geometry and initial stress pattern on the dynamic rupture process to test multiple rupture scenarios and thus investigate the most likely path(s) of a rupture that starts on the Coachella Valley segment. We consider three types of fault geometry based on the Southern California Earthquake Center Community Fault Model, and we create a three-dimensional finite-element mesh for each of them. These three meshes are then incorporated into the finite-element method code FaultMod to compute a physical model for the rupture dynamics. We use a slip-weakening friction law, and consider different assumptions of background stress, such as constant tractions and regional stress regimes with different orientations. Both the constant and regional stress distributions show that rupture from the Coachella Valley segment is more likely to branch to the Mission Creek than to the Banning fault strand. The fault connectivity at this branch system seems to have a significant impact on the likelihood of a throughgoing rupture, with potentially significant impacts for ground motion and seismic hazard both locally and in the greater Los Angeles metropolitan area.
Intimate partner violence and childhood illnesses in Cambodia: a cross-sectional study
Authors: Nakphong Michelle Kao , von Ehrenstein Ondine S 
Published: January 2020

BackgroundAround a quarter of Cambodian women reported being victim to intimate partner violence (IPV) from their current partner. Children’s exposure to familial IPV impacts psychosocial well-being and emerging research indicates associations with physical health.ObjectiveInvestigate associations between maternal experience of IPV and common childhood illnesses in Cambodia.Design, setting, participantsAnalysis of the Cambodia Demographic and Health Survey (2000, 2005, 2014) using logistic regression, including 5025 children under 5 years of age whose mothers responded to questions about experience of emotional, physical and sexual violence by current partner.Main outcome measuresReport of diarrhoea, acute respiratory infection (ARI) or fever, respectively, in children in the two weeks preceding the survey.ResultsChildren of mothers with experience of any type of IPV had estimated elevated odds of diarrhoea (adjusted OR (aOR)=1.65, 95% CI 1.39 to 1.97), estimated odds of ARI (aOR=1.78, 95% CI 1.47 to 2.16) and estimated odds of fever (aOR=1.51, 95% CI 1.31 to 1.76) compared with children of mothers without reported IPV experience. Exposure to any form of IPV corresponded to an estimated 2.65 times higher odds (95% CI 2.01 to 3.51) for reporting having both diarrhoea and ARI.ConclusionsOur findings support the notion that children’s susceptibility to diarrhoea, ARI and fever may be affected by mothers’ experience of IPV, including emotional violence. Maternal and child health programmes should train healthcare professionals to identify domestic violence and children at risk, and link victims to appropriate health and legal services.
OCTA characterisation of microvascular retinal alterations in patients with central serous chorioretinopathy
Authors: Battista Marco , Borrelli Enrico , Parravano Mariacristina , Gelormini Francesco , Tedeschi Massimiliano , De Geronimo Daniele , Sacconi Riccardo , Querques Lea , Bandello Francesco , Querques Giuseppe 
Published: January 2020

PurposeThis study aimed to describe the characteristics of microvascular retinal alterations in eyes with chronic central serous chorioretinopathy (CSC) employing optical coherence tomography angiography (OCTA) analysis.MethodsWe collected data from 472 eyes with chronic CSC from 336 patients who had OCTA obtained. Each OCTA image was graded by two readers to assess the presence of microvascular retinal alterations, including regions of vascular rarefaction/retinal hypoperfusion, enlargement of the foveal avascular zone (FAZ) and presence of telangiectasias or microaneurysms. Volume spectral domain optical coherence tomography (SD-OCT) scans were obtained through the macula and the OCT was correlated with the OCTA findings in eyes with retinal vascular alterations.ResultsOCTA displayed microvascular retinal alterations in 18 out of 474 eyes (3.6%) from 14 patients (13 male and 1 female; mean±SD age was 54.7±11.1 years). One eye displayed the presence of retinal telangiectasias, while 17 out of 18 eyes were graded as having areas of retinal vascular rarefactions, and 3 out of 17 eyes were also characterised by an enlargement of the FAZ. The parafoveal region was the location most involved by retinal vascular changes (66,7%), followed by foveal (22,2%) and perifoveal (11.1%) regions, respectively.ConclusionAlthough CSC is known to represent a choroidal disorder, retinal vascular alterations may be present in these eyes and OCTA may represent a useful tool to identify and describe them.
Women’s leadership in academic medicine: a systematic review of extent, condition and interventions
Authors: Alwazzan Lulu , Al-Angari Samiah S 
Published: January 2020

ObjectivesBecause culture reflects leadership, the making of diverse and inclusive medical schools begins with diversity among leaders. The inclusion of women leaders remains elusive, warranting a systematic exploration of scholarship in this area. We ask: (1) What is the extent of women’s leadership in academic medicine? (2) What factors influence women’s leadership? (3) What is the impact of leadership development programmes?DesignSystematic review.Data sourcesA systematic search of six online databases (OvidMEDLINE, EMBASE, CINAHL, PsycINFO, the Cochrane Library and ERIC) from the earliest date available to April 2018 was conducted. Bridging searches were conducted from April 2018 until October 2019.Eligibility criteria(1) Peer-reviewed; (2) English; (3) Quantitative studies (prospective and retrospective cohort, cross-sectional and preintervention/postintervention); evaluating (4) The extent of women’s leadership at departmental, college and graduate programme levels; (5) Factors influencing women’s leadership; (6) Leadership development programmes. Quantitative studies that explored women’s leadership in journal editorial boards and professional societies and qualitative study designs were excluded.Data extraction and synthesisTwo reviewers screened retrieved data of abstracts and full-texts for eligibility, assessment and extracted study-level data independently. The included studies were objectively appraised using the Medical Education Research Quality Study Instrument with an inter-rater reliability of (κ=0.93).ResultsOf 4024 records retrieved, 40 studies met the inclusion criteria. The extent of women’s leadership was determined through gender distribution of leadership positions. Women’s leadership emergence was hindered by institutional requirements such as research productivity and educational credentials, while women’s enactment of leadership was hindered by lack of policy implementation. Leadership development programmes had a positive influence on women’s individual enactment of leadership and on medical schools’ cultures.ConclusionsScholarship on women’s leadership inadvertently produced institute-centric rather than women-centric research. More robust contextualised scholarship is needed to provide practical-recommendations; drawing on existing conceptual frameworks and using more rigorous research methods.
Sand injection and polygonal faulting in the Great South Basin, New Zealand
Authors: Chenrai Piyaphong , Huuse Mads 
Published: January 2020

Abstract
Subsurface sediment remobilization phenomena, including sand injection complexes and mud volcano systems, have been recognized to play a significant role in basinal fluid flow and in some cases are an important part of petroleum systems. Seismic-scale wing-like anomalies, interpreted as sand injections based on their similarities with North Sea examples, have been identified within the upper Paleocene sediments of the Great South Basin, New Zealand. The structures were observed on three-dimensional seismic data at about 2.5–2.7 s two-way time beneath the seabed. The sand injections occur below a well-developed polygonal fault system within the uppermost Paleocene sediments. The wing-shaped sand injections are often located near the downward extent of polygonal fault tips, possibly implying that the injections affected polygonal fault formation. This is the first time that a seismic-scale sand injection complex has been described in the southeastern hemisphere. The study adds to an emerging realization that sand injection complexes occur in many deep-water basins and has direct implications for basin evolution and hydrocarbon exploration in the Great South Basin.
Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals
Authors: Zhang Xiuli , Li Yining , Yang Pingzhen , Liu Xiaoyu , Lu Lihe , Chen Yanting , Zhong Xinglong , Li Zehua , Liu Hailin , Ou Caiwen , Yan Jianyun , Chen Minsheng 
Published: January 2020

Objectives:
Vascular calcification is highly prevalent in patients with chronic kidney disease. Increased plasma trimethylamine N-oxide (TMAO), a gut microbiota-dependent product, concentrations are found in patients undergoing hemodialysis. However, a clear mechanistic link between TMAO and vascular calcification is not yet established. In this study, we investigate whether TMAO participates in the progression of vascular calcification using in vitro, ex vivo, and in vivo models.

Approach and Results:
Alizarin red staining revealed that TMAO promoted calcium/phosphate-induced calcification of rat and human vascular smooth muscle cells in a dose-dependent manner, and this was confirmed by calcium content assay. Similarly, TMAO upregulated the expression of bone-related molecules including Runx2 (Runt-related transcription factor 2) and BMP2 (bone morphogenetic protein-2), suggesting that TMAO promoted osteogenic differentiation of vascular smooth muscle cells. In addition, ex vivo study also showed the positive regulatory effect of TMAO on vascular calcification. Furthermore, we found that TMAO accelerated vascular calcification in rats with chronic kidney disease, as indicated by Mico-computed tomography analysis, alizarin red staining and calcium content assay. By contrast, reducing TMAO levels by antibiotics attenuated vascular calcification in chronic kidney disease rats. Interestingly, TMAO activated NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and NF-κB (nuclear factor κB) signals during vascular calcification. Inhibition of NLRP3 inflammasome and NF-κB signals attenuated TMAO-induced vascular smooth muscle cell calcification.

Conclusions:
This study for the first time demonstrates that TMAO promotes vascular calcification through activation of NLRP3 inflammasome and NF-κB signals, suggesting the potential link between gut microbial metabolism and vascular calcification. Reducing the levels of TMAO could become a potential treatment strategy for vascular calcification in chronic kidney disease.
Homocysteine Level Predicts Response to Dual Antiplatelet in Women With Minor Stroke or Transient Ischemic Attack
Authors: Li Jiejie , Wang Yilong , Li Hao , Zuo Zhiyi , Lin Jinxi , Wang Anxin , Zhao Xingquan , Liu Liping , Wang Yongjun ,   on behalf of the CHANCE Investigators
Published: January 2020

Objectives:
To investigate the relationship of homocysteine levels with the efficacy and safety of dual antiplatelet therapy in female and male patients.

Approach and Results:

The CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) randomized patients with acute minor ischemic stroke or high-risk transient ischemic attack to clopidogrel plus aspirin or aspirin alone from October 1, 2009, to July 30, 2012, in China. A subgroup of 3044 consecutive patients with baseline homocysteine levels from 73 (64%) prespecified clinical sites was analyzed. Participants were grouped by sex. Primary outcome was stroke recurrence within 90 days. Secondary outcomes consisted of composite vascular events and independent living or death. Safety outcome was any bleeding. Cox proportional-hazards models were used to assess the interaction of homocysteine levels with randomized antiplatelet therapy on efficacy and safety outcomes. A significant interaction between homocysteine levels and the randomized antiplatelet therapies was found on recurrent stroke after adjustment for confounding factors in women (
P
=0.010) but not in men (
P
=0.595). Compared with aspirin alone, clopidogrel plus aspirin significantly reduced the risk of recurrent stroke in women without elevated homocysteine levels (adjusted hazard ratio, 0.459 [95% CI, 0.271–0.776];
P
=0.004). Such benefit disappeared in female patients with increased homocysteine level. No significant interaction on functional outcome or bleeding rate was observed.

Conclusions:
Homocysteine could be a potential biomarker to discriminate the effects of dual and single antiplatelet therapy in female patients with minor ischemic stroke or high-risk transient ischemic attack.

Clinical Trial Registration:

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00979589.