bluuebunny/crossref_metadata_2025_split huggingface dataset:
Household Food Insecurity, Coping Strategies and Adolescent Girls’ Dietary Diversity Status in Hossana Town, Ethiopia.
Authors: Bancha Belay , Petrose Legese , Fanta Begidu Bashe , Endale Ashebir , Delil Romedan , Lodebo Mengistu 
Published: December 2019

Abstract
Background Globally there are 1.8 billion adolescents, comprised of 10-19 years old, represent approximately 20% of the world’s population. In Ethiopia this group represents 20-26% of general population. Despite the fact that this period is a window of opportunity to break intergenerational cycle of malnutrition, macro and micronutrient deficiencies are among leading health problems in this vulnerable age groups. Moreover, there is scarcity of data on the status of dietary diversity in this segments of the population.Methods a community based cross sectional study design was employed from May 21-June 20, 2019. Pre-tested structured questionnaire was used for data collection using cluster sampling technique to approach 451 households with adolescent girls. Data was entered in to Epi-Data version 3.1 then exported to SPSS version 23 for analysis. Descriptive and logistic regression analysis were performed. Adjusted Odd Ratios (AOR), along with corresponding 95% confidence interval (CI) were used and the level of statistical significance was declared at a p-value of <0.05.Results a total of 434 households with adolescent girls were involved in the study. We found that 41.7% of households were food insecure, only 57.8%, (C.I.53.5-62.2) of adolescent girls consumed diversified diet, with the mean DDS of 5.38 (SD=1.75). After adjusting for potential confounders, occupational status of the adolescents’ father, (AOR= 0.56, 95% C.I. 0.32-0.99 and AOR=0.26, 95% C.I. 0.17-0.47), exposure to televised media (AOR=3.36, 95% C.I. =1.55-7. 3) and household food security status (AOR=5.09, 95% C.I. =3.2-8.08) were significant predictors of dietary diversity among adolescent girls.Conclusion Significant portion of households were food insecure; practicing ranges of coping strategies which further compromised dietary diversity of adolescent girls. Poor dietary diversity adversely affects micronutrient reserves of to-be a-mother girls; the vicious cycles of malnutrition continues its far fetching effect. Given that adolescence is the second period in life with rapid growth and development, improving dietary status of this sensitive segments of the population are to be an agenda of all concerned bodies.
Explaining the impact of mHealth on maternal and child health care in low- and middle-income countries: A theory-driven scoping review
Authors: Kabongo Eveline Muika , Mukumbang Ferdinand , Delobelle Peter N/A , Nicol Edward N/A 
Published: December 2019

Abstract
Introduction Despite the growing global application of mobile health (mHealth) technology in maternal and child health, the contextual factors and mechanisms by which interventional outcomes are generated have not been subjected to extensive review. In this study, we sought to identify context, mechanisms and outcome elements from implementation and evaluation studies of mHealth interventions to formulate theories or models explicating how mHealth interventions work (or not) both for health care providers and for pregnant women and new mothers.Method An electronic search of six online databases (Medline, Pubmed, Google Scholar, Scopus, Academic Search Premier and Health Systems Evidence) was performed. Using appropriate MeSH terms and selection procedure, 32 articles were considered for analysis. A theory-driven approach, narrative synthesis, was applied to synthesise the data. Thematic content analysis was used to delineate the elements of the intervention, including its context, actors, mechanism and outcomes. Retroduction was applied to link these elements using a realist evaluation heuristic to form generative theories.Results Mechanisms that promote the implementation of mHealth by community health workers/health care providers include motivation, perceived skill and knowledge improvement, improved self-efficacy, improved confidence, improved relationship between community health workers and clients, perceived support of community health workers, perceived ease of use and usefulness of mHealth, For pregnant women and new mothers, mechanisms that trigger the uptake of mHealth and use of maternal and child health services included: perceived service satisfaction, perceived knowledge acquisition, support and confidence, improved self-efficacy, encouragement, empowerment and motivation. Information overload was identified as a potential negative mechanism for the uptake of maternal and child health services.Conclusion The models developed in this study provide a detailed understanding of the implementation and uptake of mHealth interventions and how they improve maternal and child health services in low and middle income countries. These models provide a foundation for the ‘white box’ or theory-driven evaluation of mHealth intervention and can improve the rollout and implementation where required.
Clinical Outcomes among Hemodialysis Patients with Atrial Fibrillation: A Korean Nationwide Population-based Study
Authors: Kang Yeunmi , Choi Hyung Yun , Kwon Young Eun , Shin Ji Hyeon , Won Eun Mi , Yang Ki Hwa , Oh Hyung Jung , Ryu Dong-Ryeol 
Published: December 2019

Abstract
Background: The number of patients requiring dialysis is increasing worldwide, and the atrial fibrillation (AF) prevalence among hemodialysis (HD) patients is higher than in the general population. There have been no studies of Korean AF patients undergoing HD investigating how AF affects outcomes, for example, in terms of all-cause mortality, hospitalization, and stroke events. We conducted a large-scale retrospective cohort study with data from the National Health Insurance System (NHIS) to determine how AF affects these outcomes. Methods: In 2013, the Health Insurance Review and Assessment (HIRA) service, a Korean national health insurance scheme, collected data from 21,839 HD patients for evaluating the adequacy of dialysis centers. All-cause mortality, hospitalization, and stroke events were compared between patients with and without AF. Sub-analyses compared these outcomes between patients receiving and not receiving warfarin. Results: Cox regression analysis found that AF was a significant risk factor for death from any cause (HR, 1.356; 95% CI, 1.222-1.506, P < 0.001), hospitalization (HR, 1.323; 95% CI, 1.225-1.430, P < 0.001), and hemorrhagic stroke (HR, 1.500; 95% CI, 1.050-2.141, P = 0.026). AF was not significantly associated with an increased risk of ischemic stroke. The use of warfarin was significantly associated with hemorrhagic stroke incidence (HR, 1.593; 95% CI, 1.075-2.360, P = 0.020), while there was no significant correlation between warfarin treatment and all-cause mortality, hospitalization, and ischemic stroke. Conclusions: This cohort study of Korean dialysis patients showed that AF was a risk factor for multiple outcomes among HD patients.
Predictive Role of Hypernatremia for Acute Kidney Injury in Patients with Sepsis
Authors: Zhi Deyuan , Lin Jin , Dong Lei , Ji Xiaojun , Zhuang Haizhou , Liu Zhuang , Liu Jingfeng , Duan Meili 
Published: December 2019

Abstract
Introduction Septic acute kidney injury (AKI), identified when both sepsis and AKI present, is a syndrome of acute function impairment and organ damage, accounting for ~50% AKI in ICU (Intensive Care Unit)Method This study retrospectively reviewed 591 patients who were diagnosed of sepsis and admitted to the ICU of Beijing Friendship Hospital from January 2009 to December 2014. According to the concentration of serum sodium, the 591 patients were further divided into three groups: normal group, hyponatremia group and hypernatremia group.Result PaCO 2 (P=0.014), concentration of Na + (P<0.001) and Cl - (P<0.001), BUN (P<0.001), APACHE score (P<0.001), SOFA score (P<0.001) and Glasgow score (P<0.001) showed significant differences. CK (P=0.012; OR=1.000), BUN (P=0.002; OR=1.047), Cl - (P<0.001;OR=1.255), lactic acid (P=0.001;OR=1.244), and HCO 3 - (P<0.001;OR=1.180) may be risk factors for hypernatremia in patients with sepsis. APACHE score (P=0.028;OR=1.222) and CK (P=0.014;or=1.003) may be risk factors for AKI in patients with hypernatremia. Na + suggested a good predictive ability for AKI (P<0.001; AUC: 0.586) but not for death (P=0.104)Conclusion Hypernatremia is independently associated with an increased risk and has a predictive ability of AKI in patients with sepsis.
Potential Trauma Events and the psychological consequences of Yazidi Women after ISIS Captivity
Authors: Kizilhan Jan Ilhan , Friedl Nadine , Neumann Johanna , Traub Leonie 
Published: December 2019

Abstract
Background Traumatic war experiences, like the ones the Yazidi had to undergo due to the attack of the so-called Islamic State (ISIS) in August 2014, are often followed by psychological consequences such as posttraumatic stress disorder (PTSD) and depression. A more detailed analysis of such specific survivor groups is needed, to develop and implement appropriate reparation and support measures.MethodsIn this study, 194 Yazidi women were examined. PTSD was assessed using the Essen Trauma Inventory (ETI) and depression using Beck’s Depression Inventory (BDI-II). The potential traumatic event (PTE) and further influential factors were compared between participants with PTSD and those with PTSD and depression, using inferential statistics.Results Participants showed high rates in prevalence and comorbidity for PTSD and depression. Those diagnosed with comorbid PTSD and depression experienced a higher number of PTEs and had been captured more often and for longer compared to those with PTSD. The number of PTEs experienced was then used to predict comorbid PTSD and depression.Conclusion Further research should consider the specific situation and the cultural expression of the Yazidi.
Adaptive capacities for safe clinical practice for patients hospitalised during a suicidal crisis: A qualitative study
Authors: Berg Siv Hilde , Rørtveit Kristine , Walby Fredrik. A. , Aase Karina 
Published: December 2019

Abstract
Background. Safe clinical practice for patients during a suicidal crisis is situated within a complex, non-linear and uncertain context. It involves a complex set of practices in which adaptation is perceived as a source of safety. This study aims to develop a deeper understanding of safe clinical practice and the capacity to adapt to challenges and changes in clinical care for patients hospitalised in mental health wards during a suicidal crisis. Methods. This study applied a qualitative design based on focus group and individual interviews. Twenty-five health care professionals (HCPs) participated in the focus groups, and 18 HCPs were individually interviewed. The study was conducted at open and locked wards in a university hospital in Norway that provides specialised mental health services for adults.Findings. Adaptive capacities for clinical practice were described in relation to three themes. 1) HCPs described using expertise to make sense of suicidal behaviour to support complex decision-making. Their strategies relied on setting the checklist aside to prioritise trust and making judgements beyond spoken words. They improved their understanding by seeking others’ perspectives through a collaborative sense-making process involving the health care team and the patient. 2) HCPs reported individualising the therapeutic milieu to address the diversity of patients with suicidal behaviour. Safe clinical practice was provided by creating individual clinical pathways, making trade-offs between under- and over-protection and adjusting observations 3) It was necessary for HCPs manage uncertainty to provide safe clinical practice. They did so as a team by developing mutual collegial trust, support and shared understanding. Conclusion. HCPs’ adaptive capacities are vital to the complex set of practices involved in safe clinical practice for patients hospitalised during a suicidal crisis. By using expertise, individualising the therapeutic milieu, and managing uncertainty, HCPs individually and collectively develop their capacity to adapt to challenges and changes in clinical care. Safe clinical practice cannot easily be ensured by following standards; it depends on HCP adaptations. Ward systems ensuring collegial trust and support are needed, as are arenas supporting shared understanding and collaborative sense-making. Keywords: Adaptation, sense-making, situational awareness, shared understanding, trade-offs, mental health, suicide, uncertainty
Exon Sequencing Mutation Detection Algorithm Based on PCR Matching
Authors: Chen Guobin , Xie Xanzhong 
Published: December 2019

Abstract
Background: With the development of second-generation sequencing technology, more and more DNA sequence variations have been detected. Exon sequencing is the first choice for sequencing many cancer genes, and it can be better used to identify disease status by detecting gene variants. PCR sequence is an effective method to capture that sequence of an exon in the process of sequencing. Exon sequencing sequence contains PCR primer sequence, the correct position of the sequence can be determined by PCR primer sequence, which can be found in SNP, Indel mutation point by comparing the sequence of PCR primer sequence. Results: In this paper, a matching algorithm based on the PCR primer sequence is proposed, which can effectively sequence the position of PCR primer sequence and find out the key position sequence. Then the sequencing sequence is sorted and the number of the same sequence is counted to reduce the matching times. Then, the sequenced sequence was matched with PCR primer sequence, so that the DNA position could be accurately matched and the variation in the sequenced sequence could be found more quickly. Conclusions: Compared with the traditional sequence matching method, PCR primer sequence matching method can match many sequences and find more variation. It also showed a high recall rate in the recall rate.
Characterization of a potential probiotic bacterium Lactococcus raffinolactis WiKim0068 isolated from fermented vegetable using genomic and in vitro analyses
Authors: Jung Min Young , Lee Changsu , Seo Myung-Ji , Lee Se Hee , Roh Seong Woon 
Published: December 2019

Abstract
Background: Lactococcus members belonging to lactic acid bacteria are distributed in fermented foods and widely used as starter bacteria in the production of fermented dairy products. Lactococcus raffinolactis WiKim0068 was isolated from a Korean fermented vegetable (kimchi) and its genome was analyzed. Results: The complete genome of strain WiKim0068 comprised one chromosome and two plasmids and contained 2,292,235 bp, with a G+C content of 39.7 mol%. Analysis of orthoANI values among Lactococcus genome sequences showed that strain WiKim0068 has > 67% genome sequence similarity to other species and subspecies. In addition, strain WiKim0068 displayed no antibiotic resistance and possessed nicotinate (vitamin B3) and nicotinamide (vitamin B3 amide) metabolism. Conclusion: These results add to our understanding of the genus Lactococcus and suggest that this new strain that is beneficial to human health has potential industrial applications Keywords: Lactococcus raffinolactis, genome sequence, kimchi, probiotics, vitamin B3
Association of plasma apolipoprotein B with cerebrospinal fluid Alzheimer’s disease biomarkers in patients with subjective cognitive decline
Authors: Hu Hao , Tan Lan , Bi Yan-Lin , Xu Wei , Tan Lin , Shen Xue-Ning , Hou Xiao-He , Ma Ya-Hui , Dong Qiang , Yu Jin-Tai 
Published: December 2019

Abstract
BackgroundThe preclinical stage of Alzheimer's disease (AD) has become a key target stage for future AD prevention trials. Plasma apolipoprotein, an important lipid-related factor, has been found to be involved in the pathogenesis of AD. This study was to examine whether apolipoprotein B (ApoB), apolipoprotein A-1 (ApoA1) or the ratio of ApoB and ApoA1 (ApoB/A1) were associated with early changes of cerebrospinal fluid (CSF) AD biomarkers in elderly adults with subjective cognitive decline.MethodsThis study finally included 201 cognitive normal (CN) elderly adults and 101 participants with subjective cognitive decline (SCD) from the Chinese Alzheimer’s Biomarker and Lifestyle (CABLE) database. The One-way analysis of variance, t-test, Kruskall-Wallis test and Chisquare test were applied in the intergroup comparisons. Multiple linear regression models were used to examine the cross-sectional associations of plasma ApoB, ApoA1 and ApoB/A1 levels with CSF AD-related biomarkers.ResultsCompared with the control group, SCD participants with significant AD biological characteristics had lower ApoB levels. In the total participants, higher level of plasma ApoB was associated with increases in CSF Aβ42 (p = 0.0009) and Aβ42/40 (p = 0.0038) as well as decreases in CSF t-tau/Aβ42 (p < 0.0001) and p-tau/Aβ42 (p < 0.0001), independent of APOEɛ4 status. In the further subgroup analysis, these associations were much more significant in the SCD participants. In addition, higher levels of plasma ApoB were also found associated with decreases in CSF t-tau (p = 0.0224), p-tau (p = 0.0086) and Aβ40 (p = 0.0297) in the SCD subgroup. Furthermore, we found that these protective associations between plasma ApoB and CSF AD core biomarkers were much more significant in the overweight participants. Results showed no association between ApoA1 and all CSF biomarkers in either total participants or subgroups. ConclusionsThis study is the first to find protective associations of plasma ApoB, but not ApoA1, with CSF AD core biomarkers in elderly adults, and these associations were more significant in SCD individuals. This finding indicated that ApoB may play a protective role in the preclinical stage of AD. Identifying the underlying mechanisms may contribute to the discovery of new pathogenic mechanisms and therapeutic targets.
BioTracs: A transversal framework for computational workflow standardization and traceability
Authors: Abi-Ghanem Joséphine , Ouattara Djomangan Adama 
Published: December 2019

Abstract
Background The need of digital tools for integrative analysis is today important in most scientific areas. It leads to several community-driven initiatives to standardize the sharing of data and computational workflows. However, there exists no open agnostic framework to model and implement computation workflows, in particular in bioinformatics. It is therefore difficult for data scientists to share transparently and integrate heterogeneous analysis processes coming from different scientific domains, programing languages, projects or teams.Results We present here BioTracs, a transversal framework for computational workflow standardization and traceability. It is based on PRISM architecture (Process Resource Interfacing SysteM), an agnostic open architecture we introduce here to standardize the way processes and resources can be modelled and interfaced in computational workflows to ensure traceability, reproducibility and facilitate sharing. BioTracs is today implemented in MATLAB and available under open source license on GitHub. Several BioTracs-derived applications are also available online. They were successfully applied to large-scale metabolomics and clinical studies and demonstrated flexibility and robustness.Conclusions As an implementation of the PRISM architecture, BioTracs paved the way to an open framework in which bioinformatics could specify ad model workflows. PRISM architecture is designed to provide scalability and transparency from the code to the project level we less efforts. It could also be implemented using open object-oriented languages such as Python, C++ or java.
Optimal implantation site of orthodontic micro-screws in the mandibular anterior region based on CBCT
Authors: Wang Yannan , Quan Shi , Xu Juan , Wang Feng 
Published: December 2019

Abstract
Background To determine the optimal implantation site of orthodontic micro-screws based on cone beam computed tomography (CBCT) analysis in the mandibular anterior tooth region, provide a theoretical basis for orthodontic implant placement and improve post-implantation stability. Methods Forty patients who underwent CBCT scanning were selected for this study. CBCT scanning was applied to measure the interradicular distance, buccolingual dimension, labial cortical bone thickness and lingual cortical bone thickness between mandibular anterior teeth at planes 2 mm, 4 mm, 6 mm and 8 mm below the alveolar ridge crest. The data were measured and collected to obtain a comprehensive evaluation of the specific site conditions of the alveolar bone. Results The interradicular distance, buccolingual dimension and labial cortical bone thickness between the mandibular anterior teeth were positively correlated with the distance below the alveolar ridge crest (below 8 mm). The interradicular distance, buccolingual dimension, labial cortical bone thickness and lingual cortical bone thickness were all greater than those in other areas between the lateral incisor root and canine incisor root 4 mm, 6 mm, and 8 mm below the alveolar ridge crest. Conclusion The area between the lateral incisor root and the canine incisor root in planes 4 mm, 6 mm, and 8 mm from the alveolar ridge crest can be used as safe sites for implantation, while 8 mm below the alveolar ridge crest can be the optimal implantation site. An optimal implantation site can be 8 mm below the alveolar ridge crest between the lateral incisor root and the canine incisor root.
WITHDRAWN: The effect of removable orthodontic appliances on oral microbiota: systematic review
Authors: Lucchese Alessandra , Pellegrino Marianna , Montini Eugenio , Liguori Alessandra , Manuelli Maurizio 
Published: December 2019

Abstract
Background Removable orthodontic appliances due to plaque accumulation and oral microbe colonization, might be associated with intraoral adverse effects on enamel or periodontal tissues. The present systematic review was carried out to evaluate both qualitatively and quantitatively the microbiological changes occurring during orthodontic therapy with removable orthodontic appliances. Methods PubMed, Cochrane, EMBASE, Web of Science, Scopus, Ovid Medline, Dentistry & Oral Sciences Source and Vita-Salute San Raffaele University databases were searched. The research included every article published up to December 2018. The Preferred Reporting Items for Reporting Systematic reviews and Meta Analyses (PRISMA) protocol and the ‘Swedish Council on Technology Assessment in Health Care Criteria for Grading Assessed Studies’ (SBU) method were adopted to conduct this systematic review. Results The current study has moderate/high evidence, according with SBU method. It demonstrates that removable appliances do influence the oral microbiota, with significant alterations just 15 days after the beginning of therapy, independently from the type of appliance. Furthermore, the levels of oral pathogens decrease significantly or even returned to pre-treatment levels several months later the therapy end. Conclusions This review suggests that orthodontic treatment with removable appliances might not induce permanent changes to oral microflora. Protocol: PROSPERO database registration number CRD42019121762.