bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring health professionals’ capability to respond to health consumers’ health literacy needs: a scoping review
Authors: Nash Rosie , Choi-Lundberg Derek , Eccleston Claire , Elmer Shandell , Melis Gina , Douglas Tracy , Eslick Melanie , Triffett Laura , Mather Carey , Maxwell Hazel , Martin Romany , Truong Phu , Sward Jonathon , Watkins Karen , Bird Marie-Louise 
Published: December 2024

Abstract
Health literacy-responsive health professionals will be increasingly important in addressing healthcare access and equity issues. This international scoping review aims to understand the extent and ways in which health professionals respond to healthcare users’ health literacy, identifying tools used to measure health literacy responsiveness and training to support the development of these attributes. Four online databases were searched. Using Covidence software and pre-determined inclusion/exclusion criteria, all articles were screened by two authors. Data were extracted using a researcher-developed data extraction tool. From the 1531 studies located, 656 were screened at title and abstract and 137 were assessed at full text; 68 studies met the inclusion criteria and 61 were identified through hand searching resulting in 129 papers in total. Five overlapping thematic elements describing thirty attributes of health literacy responsive health professionals were identified: (i) communication, (ii) literacies, (iii) andragogy, (iv) social/relational attributes and (v) responding to diversity. Other concepts of ‘tailoring’ and ‘patient-centred care’ that cut across multiple themes were reported. Forty-four tools were identified that assessed some aspects of health literacy responsiveness. Thirty of the tools reported were custom tools designed to test an intervention, and 14 tools were specifically employed to assess health literacy responsiveness as a general concept. Seventy studies described education and training for health professionals or students. This scoping review provides a contemporary list of key attributes required for health literacy-responsive health professionals, which may serve as a foundation for future health literacy research including the development of curricula in health professional education and tools to measure health professional health literacy responsiveness.
The key role of visual coordination in the formation of collective routinized actions
Authors: Calluso Cinzia , Marino Alessandro , Devetag Maria Giovanna , Prencipe Andrea 
Published: December 2024

Abstract
Using the theoretical framework of joint actions, here we hypothesize that routines’ formation is regulated by visual coordination and task difficulty. We conducted a laboratory experiment manipulating the availability of visual information and the difficulty of routinization. The presence of visual information allowed participants to reach the game’s goal faster, although the performance was less accurate. Task difficulty had a limited impact. Overall, visual coordination appears to regulate the speed–accuracy trade-off of routines, playing a pivotal role in complex joint actions.
Acute coronary syndrome rates by age and sex before and during the COVID-19 pandemic in Israel: nationwide study
Authors: Kagan Alexander , Zwas Donna R , Haklai Ziona , Levine Hagai 
Published: December 2024

Abstract

Background
There have been reports of sharp declines in acute coronary syndrome (ACS) during the COVID-19 pandemic. The study aims to assess nationwide ACS emergency department (ED) visit rates across age and sex subgroups and the general population, with a comparison before and throughout the pandemic’s various phases.

Methods
A multiple interrupted time series analysis was used to assess 61 349 ACS nationwide hospital visits from January 2018 to December 2021 at monthly intervals. The study period was divided into three periods: January 2018–February 2020 (pre-pandemic period); March 2020–January 2021 (early-pandemic period); February 2021–December 2021 (late-pandemic period). Segmented regression with a seasonally adjusted autoregressive moving average structure was used to build predictive models with an estimated reference trendline (counterfactual).

Results
Over 11 months of the early-pandemic period (lockdowns), the largest decrease in visits was seen in women aged 65 and above, of 18.4% [incidence rate ratio (IRR) 0.82; 95% confidence interval (CI) 0.77–0.86]. The lowest decrease was observed in men aged 25–64, of 7.2% (IRR 0.93; 0.91–0.94). During the late-pandemic period, which included high vaccination coverage and no lockdowns, the largest further decrease was in women aged 25–64 of 20.1% (IRR 0.80; 0.75–0.84) on average.

Conclusions
The pandemic influenced ACS ED visits variably, with substantial declines during phases of high COVID-19 morbidity and mortality. Older individuals, particularly women, demonstrated the largest decrease in ACS ED visits, highlighting the need for tailored public health strategies to maintain public confidence in access to critical care during future health emergencies.
Intelligent planning and scheduling strategies for low-carbon distribution networks under high proportions of renewable energy integration
Authors: Li Xuejun , Wang Linfeng , Dong Yu , Liu Hang , Feng Shengtao 
Published: December 2024

Abstract
This article proposes an intelligent planning and scheduling strategy for low-carbon distribution networks under the condition of high-penetration renewable energy. Initially, based on the deep neural network and particle swarm optimization algorithm models, it forecasts the power loads as well as photovoltaic and wind generation capacities. Through the multitime scale optimal scheduling theory, it dynamically adjusts the operational state of the distribution network, striving to minimize carbon emissions and enhance energy utilization efficiency. This holds significant guiding implications for the realization of intelligent planning in distribution networks.
Class Conflict as Catalyst of Trust: A New Research Agenda for International Political Sociology
Authors: Simon Hendrik 
Published: December 2024

Abstract
While it is widely believed that the ongoing transformation of the global economy and the accompanying fragmentation of capitalist production is undermining solidarity, cohesion and trust among workers, this article presents a contrasting perspective: my main argument is that conflicts between capital and labor are complex processes that can serve as catalysts for fostering both solidaristic trust among workers as well as antagonistic trust between capital and labor representatives. While these varieties of trust are in a certain political tension with each other, they both point to the fact that conflicts play a crucial role in politicizing workers and revitalizing their collective power at local, regional, national, transnational, and global levels of the production process. What is at stake in these conflicts is not only collective bargaining, but also how the “political” of labor is constituted under conditions of the global capitalist production, namely via the (re)construction of political consciousness and common identities among workers in daily practices. I develop this argument theoretically by drawing on organizational, industrial, and conflict sociology as well as social movement studies and underpin it empirically with reference to three qualitative and ethnographic research projects on trust and capital–labor conflicts at national and transnational levels. As I show, trust and (class) conflict are not mutually exclusive, but can reinforce each other dialectically, true to the motto: In conflict, we trust!
The Effect of International Actors on Public Support for Government Spending Decisions
Authors: Pinto Pablo M , Rickard Stephanie J , Vreeland James Raymond 
Published: December 2024

Abstract
Does the intervention of an international organization in domestic politics render policy change more popular? While voters may ultimately care only about policy outcomes, the involvement of international actors often seems to lead to resentment. Still, citizens may have greater faith in the wisdom of international actors than in their own government. As others have argued, a well-respected international actor might provide a cue, especially for voters considering controversial policies like spending cuts. We test this argument in a novel pre–post experimental panel study conducted in Spain. We find that citizens become less opposed to unpopular spending cuts when informed that they are required by an international institution. The effects differ, however, across the two organizations that we test: They are stronger for the European Union than for the International Monetary Fund. Our findings lend support to studies arguing that the endorsement of specific international organizations can help push through otherwise unpopular policies.
Quantification of maternal and fetal valaciclovir exposure in a pharmacokinetic study of cytomegalovirus-infected pregnant women treated to prevent vertical transmission
Authors: Faure-Bardon Valentine , Bouazza Naïm , Benaboud Sihem , Foissac Frantz , Rouillon Steeve , Froelicher-Bournaud Léo , Leruez-Ville Marianne , Guilleminot Tiffany , Lui Gabrielle , Tréluyer Jean-Marc , Ville Yves 
Published: December 2024

Abstract

Background
In cases of maternal primary infection with cytomegalovirus (CMV-MPI) maternal treatment with oral valaciclovir 8 g/day has been shown to reduce the risk of fetal infection. The pharmacological profile of this high dosage during pregnancy is not yet known.

Objectives
To quantify maternal-fetal exposure to valaciclovir 8 g/day in a population pharmacokinetic (popPK) study.

Methods
Between October 2019 and April 2023, pregnant women referred for CMV-MPI were offered to participate following: (i) CMV-MPI &lt;14 weeks of gestation; (ii) acceptance of valaciclovir 8 g/day; and (iii) consent for amniocentesis. Amniotic fluid was tested for (i) CMV PCR for prenatal diagnosis; and (ii) dosage of aciclovir concentration (the active form of valaciclovir). Maternal serum levels of aciclovir were also measured. Aciclovir assays in both compartments were used for popPK analysis. Pharmacokinetics were described using non-linear mixed-effect modelling.

Results
We prospectively included 119 women with their 122 fetuses. CMV-MPI occurred at a median of 3.0 (range: −12; + 14) weeks of gestation. CMV-infected pregnant women were treated at a median of 12.3 (range: 4.6–21.4) weeks of gestation for a median duration of 35 days (range: 7–90 days). Median pharmacokinetic parameters (Cmin, Cmax and AUC0–24) were all successfully defined in both maternal blood and amniotic fluid compartments. No differences in aciclovir exposure were observed between infected (n = 12, 9.8%) and non-infected fetuses. Simulations showed that after a last maternal dose, aciclovir concentration would be undetectable in the amniotic fluid after 43–47 h.

Conclusions
In this popPK study, maternal and fetal pharmacokinetics were established using in vivo data. The results provide a better understanding of how this fetal therapy works.
Behavioural impact of antibiotic stewardship in children in primary care: interviews with GPs and parents
Authors: D’hulster Erinn , Digregorio Marina , De Burghgraeve Tine , Luyten Jeroen , Coenen Samuel , Anthierens Sibyl , Verbakel Jan Y 
Published: December 2024

Abstract

Background
The ARON study, a randomized controlled trial, assesses a behavioural intervention incorporating clinically guided C-reactive protein (CRP) point-of-care testing and a parental information booklet to reduce inappropriate antibiotic prescriptions for acutely ill children in Belgian primary care.

Objectives
To explore GP and parent views and experiences regarding the ARON trial intervention.

Methods
We conducted a qualitative embedded process evaluation in Belgian general practice. Semi-structured interviews were held with purposively sampled GPs and a convenience sample of mothers of acutely ill children presenting to primary care. Data were analysed using inductive thematic analysis.

Results
Thirty-four interviews were conducted with 17 GPs and 17 parents from the intervention arm, and four themes were identified. The first theme centres on the supportive role of CRP point-of-care testing in reducing diagnostic uncertainty and decreasing inappropriate prescriptions. The second theme explores the use of CRP in managing perceived parental expectations of antibiotics. The third theme discusses the use of intermediate CRP levels (above the trial’s 5 mg/L cut-off) as an indicator of serious infection, as opposed to its intended role in the trial as a rule-out factor. The final theme delves into the dual functionality of the booklet, enhancing self-management and offering reassurance through safety-netting advice. A logic model depicts the assumptions and (un)anticipated dynamics underlying the relationships between these themes and their subthemes.

Conclusion
Both GPs and parents consider the intervention to be a helpful complementary tool during consultations for acutely ill children.
Variations in digital health literacy for pediatric caregivers of hospitalized children: implications for digital health equity
Authors: Crook Steven , Rosenbluth Glenn , Glidden David V , Fernandez Alicia , Lee Chuan-Mei , Avina Lizette , Magana Leslie , Washington Kiana , Bardach Naomi S 
Published: December 2024

Abstract

Objectives
We sought to assess whether race, ethnicity, and preferred language were associated with digital health literacy in pediatric caregivers.

Materials and Methods
We used linear regression to measure associations between 3 eHealth Literacy Questionnaire (eHLQ) domains (score range: 1-4) and demographic characteristics.

Results
Non-Latinx White respondents (n = 230) had highest adjusted mean eHLQ scores: 3.44 (95% confidence interval: 3.36-3.52) in “Ability to engage,” 3.39 (3.31 to 3.47) in “Feel safe and in control,” and 3.34 (3.25 to 3.41) in “Motivated.” By contrast, Spanish-preferring Latinx respondents (n = 246) had lower adjusted mean scores across all 3 eHLQ domains: 2.97 (P &lt; .0001), 3.21 (P = .004), and 3.19 (P = .033), respectively.

Discussion
Our study contributes insights in variations across ethnoracial and language preference groups by different eHLQ domains, with implications for addressing digital health inequities.

Conclusion
Digital health literacy was lower in Spanish-preferring Latinx pediatric caregivers compared to non-Latinx White caregivers across 3 eHLQ domains. It was lower than English-preferring Latinx caregivers in “Ability.”
2-Oxoglutarate-dependent dioxygenases as oxygen sensors: their importance in health and disease
Authors: Lee Peter W T , Kobayashi Minoru , Dohkai Takakuni , Takahashi Itsuki , Yoshida Takumi , Harada Hiroshi 
Published: December 2024

Abstract
Since low oxygen conditions below physiological levels, hypoxia, are associated with various diseases, it is crucial to understand the molecular basis behind cellular response to hypoxia. Hypoxia-inducible factors (HIFs) have been revealed to primarily orchestrate the hypoxic response at the transcription level and have continuously attracted great attention over the past three decades. In addition to these hypoxia-responsive effector proteins, 2-oxoglutarate-dependent dioxygenase (2-OGDD) superfamily including prolyl-4-hydroxylase domain-containing proteins (PHDs) and factor inhibiting HIF-1 (FIH-1) has attracted even greater attention in recent years as factors that act as direct oxygen sensors due to their necessity of oxygen for the regulation of the expression and activity of the regulatory subunit of HIFs. Herein, we present a detailed classification of 2-OGDD superfamily proteins, such as Jumonji C-domain-containing histone demethylases, ten-eleven translocation enzymes, AlkB family of DNA/RNA demethylases and lysyl hydroxylases, and discuss their specific functions and associations with various diseases. By introducing the multifaceted roles of 2-OGDD superfamily proteins in the hypoxic response, this review aims to summarize the accumulated knowledge about the complex mechanisms governing cellular adaptation to hypoxia in various physiological and pathophysiological contexts.
Circulating lipocalin-2 across the adult lifespan
Authors: Bauer Carlie , Smith Cassandra , Vogrin Sara , Palmer Andrew S , Woessner Mary , Landen Shanie , Jacques Macsue , Byrnes Elizabeth , Eynon Nir , Sim Marc , Lewis Joshua R , Levinger Itamar 
Published: December 2024

Abstract
Lipocalin-2 (LCN2), a hormone produced by adipocytes, osteoblasts, and renal tubular cells, is implicated in age-related diseases, including cardio-metabolic disease. To understand the role LCN2 may play in pathological states, we first need to elucidate the relationship between circulating LCN2 with indices of cardio-metabolic health during “normal” aging. This study examined the relationship between serum levels of LCN2, age, and cardio-metabolic measures across the adult lifespan in males and females. We conducted a pooled cohort analysis including 124 community-dwelling males (n = 52) and females (n = 72) (age 20–87 yr, median BMI 25.92 [23.04, 29.81] kg/m2). Serum LCN2 was analyzed using a two-step chemiluminescent microparticle monoclonal immunoassay. The relationship between LCN2 and age was evaluated by linear regression and cubic spline. Simple linear regressions were performed to investigate the relationship between LCN2 and the following variables: BMI, VO2peak, serum glucose, and body composition (DXA). For every 1 yr increase in age, LCN2 levels were 0.26 mg/L higher (P = .007, 95% CI [0.07, 0.45]). Each 1 unit increase in BMI (kg/m2) was associated with 0.88 mg/L higher LCN2 levels (P = .027, [0.10, 1.66]) and each 1 unit increase in VO2peak (mL/kg/min) was associated with 0.38 mg/L lower LCN2 (p = .003, [−0.63, −0.13]).There was no significant relationship between LCN2 and sex, glucose levels or body composition (all p &gt; .05). LCN2 increased linearly across the adult lifespan while it decreased as fitness level increased. Future research should build on these findings to determine whether LCN2 can be used as a biomarker for chronic disease and if exercise can mitigate age-related disease associated with LCN2 changes.
A sign language journey to the land of smiles: Thailand study abroad
Authors: Meek David R , Ballentine Pauline M , Buchanan Beverly J , Clark M Diane , Cohen Brad S , Simmons Paul K 
Published: December 2024

Abstract
This qualitative study focused on the synergistic experience of a group of Deaf1 and hearing participants during a 2-week international study-abroad program to investigate the impact of immersing hearing American Sign Language (ASL) undergraduate majors with culturally Deaf faculty and doctoral students. 20 participants included undergraduate students who were ASL majors, Deaf doctoral students, faculty members, and an interpreter. Data included narratives with the Deaf faculty leader and the hearing ASL interpreter, a content analysis with the hearing undergraduates, and a section focused on the Deaf perspective with a thematic analysis with the Deaf faculty, students, and alumni. 6 themes emerged in the discussion of students’ experiences during the tour in Thailand, including being immersed into the Deaf world, the challenge of not comprehending what was happening, the patience of the Thai people, experiencing cultural differences, receptive skills improving, comprehension increasing, and issues related to scheduling of events. The impact of both international and multicultural influences are discussed. Additionally, recommendations for travel agencies that work with Deaf study-abroad leaders are included.
A Bayesian approach to the analysis of dose–response data: estimating natural survivorship without Abbott’s correction and inclusion of overdispersion estimates
Authors: Caprio Michael A , Malaquias Jose B , Reisig Dominic 
Published: December 2024

Abstract
We assessed the utility of a Bayesian analysis of dose–mortality curves using probit analysis. A Bayesian equivalent of a conventional single population probit analysis using Abbott’s correction demonstrated the ability of the Bayesian model to recover parameters from generative data. We then developed a model that removed Abbott’s correction and estimated natural survivorship as part of the overall model fitting process. Based on WAIC (information content) scores, this model was selected over the model using Abbott’s corrected data in 196 out of 200 randomly generated datasets. This suggests that considerable information on control survivorship exists in response to treated doses in a bioassay, information that is partially removed when using Abbott’s correction. Overdispersion in count data is common in ecological data, and a final model was developed that estimated overdispersion (kappa) as part of the model fitting process. When this model was compared to a model without overdispersion, it was selected as the best model in all 200 randomly generated datasets when kappa was low (5–20, high levels of overdispersion), while the 2 models performed equally well when kappa was large (500–2,000, low levels of overdispersion). The model with overdispersion was used to estimate parameters from bioassays of 10 populations of Helicoverpa zea (Lepidoptera: Noctuidae) exposed to Vip3a toxin, identifying 26 out of 45 pairwise comparisons that showed strong evidence of differences in LC50 estimates, adjusted for multiple comparisons.
The law for mini-organ prototypes in a dish. Mapping the legal status options for organoids in Swiss law
Authors: Fausch Inesa 
Published: December 2024

ABSTRACT
Advances in generating human mini-organ prototypes will further improve fundamental research,1 disease modeling,2 drug screening3 and the development of personalized medicine.4 Currently, there is no legal definition, identified legal status, or existing regulatory framework for organoids. Ethical discussions regarding brain and embryo-like mini-organ models leave researchers uncertain about the extent to which work on any organoids is legally permissible. The legal protection of human embryos, many other separated human body parts5 as well as organoids is more complex than the application of the traditional rules of rights in rem or of the law of personality alone. The paper’s focus is to examine whether the legal status of organoids or lack thereof, could influence their concrete regulatory framework, or whether a legal status in private law is necessary for their regulation. This paper deliberately chooses not to attempt a unifying theory of law but rather to argue for a possible regulation of organoids using the example of Swiss law.6 While, at present, there is no comprehensive research addressing either the status or the regulation of organoids, we believe that the argumentation presented could improve the overall understanding of how a potential organoid regulation could be set out within national legal frameworks.
Practical Wisdom, Clinical Judgments, and the Agential View
Authors: Jotterand Fabrice , Derse Arthur , Spellecy Ryan , Stawski Chris , Kalet Adina 
Published: December 2024

Abstract
This paper argues that practical wisdom represents a useful framework for understanding the synthesis of the scientific, technical, and moral dimensions of medical practice and may, therefore, guide the meaningful integration of concepts of competence and character into the education and support of both the technical and moral agency of medical professionals. The authors show the importance of practical wisdom in three distinct domains: (1) in effective deliberation in clinical judgments; (2) in helping clinicians flourish by making wise decisions in light of the moral and emotional challenges they face in their practice; and (3) in helping physicians navigate between the rights of patients, the physician’s own moral good, and the objective good intrinsic to medicine. To promote the physician’s own moral good and the objective good intrinsic to medicine, the authors propose a philosophical position, the agential view, that preserves an essentialist view of medicine but emphasizes the necessity to develop a personal moral philosophy of clinical practice.