bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypertension But Not Heart Failure or Coronary Artery Disease is Associated with Mental Disorders
Authors: Namdar Hossein , Jamshidi Fatemeh , Ezzati Davoud , Zakeri raana , Sadat-Ebrahimi Seyyed-Reza 
Published: July 2020

Abstract
Background: Previous studies have emphasized the significant association between depression, anxiety, and stress and hypertension (HTN), heart failure (HF), and coronary artery disease (CAD). However, among included patients with HF or CAD in those studies, there were considerable proportions of patients with concomitant HTN and vice versa leading to some possible bias in final estimations. Therefore, we aimed to exclude those patients with concomitant diseases and reassess the association between these three prevalent cardiovascular diseases with three important psychological disorders. Methods: In this cross-sectional study, 300 patients were evaluated, including 100 with HTN (without a history or concomitant HF or CAD), 100 with HF (without HTN or CAD), and 100 with CAD (without HTN or HF). Moreover, 100 healthy volunteers were considered as the control group. Depression Anxiety Stress Scale 21 was used to measure the magnitude of depression, anxiety, and stress. Result: The average scores of 4.6, 9.1, 3.7, and 4.4 for depression, 3.9, 11.1, 4.1, and 3.6 for anxiety and 6.5, 13.6, 5.2, and 5.4 for stress were detected in control, HTN, CAD, and HF groups, respectively. The depression, anxiety, and stress scores of HTN group were significantly higher than the control (p<0.05), CAD (p<0.05) and HF (p<0.05) groups; this is while these scores were not significantly different between other study groups (p>0.05).Conclusion: Our study demonstrated a significantly higher magnitude of psychological disorders in patients with HTN. However, their magnitude in patients with HF and CAD without concomitant HTN were similar to those in healthy participants.
The Inhibitory Effect of Curcumin Via Fascin Suppression Through JAK/STAT3 Pathway on Metastasis and Recurrence of Ovary Cancer cells.
Authors: Kim Mi Ju 
Published: July 2020

Abstract
Background: fascin is an actin-binding protein and highly expressed in ovarian cancer cells. It is associated with metastasis of cancer and may be a useful prognostic factor. Anticancer activity of curcumin is related to its effect on several signaling mechanisms. Although there have been many reports regarding the anticancer properties of curcumin, its inhibitory effects on migration and invasion of ovarian cancer cells, particularly in the context of fascin expression, have not been reported. The purpose of this study was to investigate the effect of curcumin on fascin expression in ovarian cancer cells and to propose a possible mechanism for the anticancer activity of curcumin through reduced fascin expression. Methods : SKOV3, human epithelial ovary cancer cell line, was cultured with curcumin at various dose and duration. The fascin was quantified using cell viability test and Western blot. To determine the effect of curcumin on the upstream pathway of fascin expression, the signal transducer and activator of transcription 3 (STAT3) was analyzed by sandwich-ELISA. Attachment assay, migration assay and invasion assay were analyzed to approve the change of cellular invasiveness of ovary cancer after curcumin. To determine the morphological changes of ovarian cancer cells by curcumin, immunofluorescence was performed.Results : MTS assays showed that cell viability was different at various concentration of curcumin, and as concentration increased, cell viability tended to decrease. Curcumin appears to suppress fascin expression, even with a minimal concentration and short exposure time. Also, curcumin may suppress fascin expression in ovarian cancer cells through STAT3 downregulation. The attachment assay, migration assay and invasion assay of the ovarian cancer cells exhibited a statistically significant decrease. Immunofluorescence revealed a change of cell shape from a typical form of uninfluenced cells to a more polygonal appearance, with a significant reduction in filopodia formation.Conclusions: Curcumin reduces fascin expression through JAK/STAT3 pathway inhibition, which interferes with the cellular interactions essential for the metastasis and recurrence of ovarian cancer cells. Higher curcumin concentrations and longer exposure times concomitantly decreased fascin expression.
The difference between actual and perceived body weight association with mental wellbeing in a sample of 10-11 year old children in England: a cross sectional survey
Authors: Nnyanzi Lawrence Achilles , Kunonga Edward , Mujuni Brian , Wamala Patrick , Muwagga Anthony M , Kabanda Joseph , Ibingira Charles 
Published: July 2020

Abstract
Background

In a society, where the prevalence of childhood overweight and obesity is relatively high, making childhood overweight the ‘norm’, some children view themselves as being of ideal weight when they are actually overweight or obese. At the same time, there is also evidence showing that children as young as nine, are becoming increasingly body conscious, leading to a potential overestimation of body weight status in these children. The aim of this study was to assess the association between mental wellbeing and perceived and actual body weight status among children aged 10–11 years old.
Methods

The study was undertaken in 24 primary schools within one health authority area in the North East of England, UK. 264 children aged 10–11 years old (Year 6) self completed a series of questionnaires within school hours which included the general health questionnaire (GHQ), strengths and difficulties questionnaire (SDQ), and specific questions about how they perceived their body weight status prior to being weighed and measured as part of the National Child Measurement Programme (NCMP). The parents of participating children also completed and returned a form reporting the height and weight results from their child’s NCMP feedback letter.
Results

Most of the children misclassified their body weight status, but not always in the same direction. Approximately 1 in 10 ideal weight children perceived themselves to be overweight. However over three quarters of overweight children perceived themselves to be of an ideal weight. In this study sample, mental well-being was not associated with actual body weight status, but it was associated with perceived body weight status; those children who perceived themselves to be an ideal body weight, regardless of what their actual body weight status, had better mental well-being than those who perceived themselves to be either underweight, overweight, or obese (again, regardless of their actual BMI).
Conclusions

The study strengthens the understanding of the potential relationship between mental well-being and perceived body weight status in 10–11 year old children. The phenomenon of children misperceiving their weight status could on one hand lead to unnecessary mental health problems whilst on the other hand undermine efforts to support interventions aimed towards combating weight problems among children. Surveillance and monitoring programmes e.g. the NCMP which weigh and measure children and feedback their true weight status need to be encouraged.
Nanoscale Real-Time Detection of Quantum Vortices at Millikelvin Temperatures
Authors: Guthrie Andrew , Kafanov Sergey , Noble Mark , Pashkin Yuri , Pickett George , Tsepelin Viktor , Dorofeev Alexander , Krupenin Vladimir , Presnov Denis 
Published: July 2020

Abstract
Since we still lack a theory of classical turbulence, attention has focused on the conceptually simpler turbulence in quantum fluids. Can such systems of identical singly-quantized vortices provide a physically accessible "toy model" of the classical counterpart? That said, we have hitherto lacked detectors capable of the real-time, non-invasive probing of the wide range of length scales involved in quantum turbulence. However, we demonstrate here the real-time detection of quantum vortices by a nanoscale resonant beam in superﬂuid 4He at 10 mK. The basic idea is that we can trap a single vortex along the length of a nanobeam and observe the transitions as a vortex is either trapped or released, which we observe through the shift in the resonant frequency of the beam. With a tuning fork source, we can control the ambient vorticity density and follow its influence on the vortex capture and release rates. But, most important, we show that these devices are capable of probing turbulence on the micron scale.
Atmospheric Relative Humidity Can Increase the Spread of COVID-19
Authors: Zheng Qing , Wang Lei , Wang Hongbin , Gui Wenjing 
Published: July 2020

Abstract
COVID-19 has been spreading around the world since the end of 2019, and there is no sign of a slowdown. Previous studies on seasonality of similar infectious diseases have hinted that meteorological factors may influence COVID-19 outbreaks as well1. Here we show, based on data collected in 132 cities of China, that relative humidity, as an essential meteorological indicator, is positively correlated with the growth rate of incidence of COVID-19, which contradicts previous research findings. Our result suggests an increasing risk of COVID-19 cases as summer and rain seasons arrive in many places of the world. They also help countries and regions to formulate pandemic prevention and control measures and policies according to local meteorological characteristics.
Systematic elucidation of the molecular mechanism of scutellarin against osteoarthritis based on network pharmacology
Authors: Guo Shijia , Zhang Xinan , Sun mingli 
Published: July 2020

Abstract
Background

Scutellarin was reported to exerted inhibitive effects on osteoarthritis, However, the detailed mechanisms remain unclear. In this study, we investigated underlying multi-target mechanisms of scutellarin against osteoarthritis by using network pharmacology analysis and molecular docking.
Results

Scutellarin exerted inhibitive effects on osteoarthritis by regulating the function of several new signaling pathways, such as TNF signaling pathway, NOD-like receptor signaling pathway and HIF-1 signaling pathway. Molecular docking analysis showed there was better interaction between scutellarin and several NF-kB signaling proteins, including NFKBIA, RELA and NFKB1. In addition, the results showed Pi-cation, Pi-donor-hydrogen and Pi-alkyl were the main forms of interaction between scutellarin and NFKB1 and NFKBIA, Pi-Pi T-shaped, Pi-alkyl and hydrogen bonding were the main forms of interaction between scutellarin and RELA.
Conclusion

Taken together, TNF signaling pathway, NOD-like receptor signaling pathway and HIF-1 signaling pathway were possible signaling pathways, NFKBIA, RELA and NFKB1were possible targets associated with the activities of scutellarin against osteoarthritis. However, it is imperative that these targets should be thoroughly verified by in vitro and in vivo experiments.
The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysis
Authors: Vuong Huy Gia , Nguyen Thu Quynh , Ngo Tam N.M , Nguyen Hoang Cong , Fung Kar-Ming , Dunn Ian F. 
Published: July 2020

Abstract
Background
There are controversial results concerning the prognostic implication of TERT promoter mutation in glioma patients concerning MGMT status. In this meta-analysis, we investigated whether there are any interactions of these two genetic markers on the overall survival (OS) of glioma patients.
Methods
Electronic databases including PubMed and Web of Science were searched for relevant studies. Hazard ratio (HR) and its 95% confidence interval (CI) for OS adjusted for selected covariates were calculated from the individual patient data (IPD), Kaplan-Meier curve (KMC), or directly obtained from the included studies.
Results
A total of nine studies comprising 2819 glioma patients were included for meta-analysis. Our results showed that TERT promoter mutation was associated with a superior outcome in MGMT-methylated gliomas (HR = 0.73; 95% CI = 0.55–0.98; p-value = 0.04), whereas this mutation was associated with poorer survival in gliomas without MGMT methylation (HR = 1.86; 95% CI = 1.54–2.26; p-value < 0.001). TERT-mutated glioblastoma (GBM) patients with MGMT methylation benefited from temozolomide (TMZ) treatment (HR = 0.33; 95% CI = 0.23–0.47; p-value < 0.001). MGMT methylation was not related with any improvement in OS in TERT-wild type GBMs (HR = 0.80; 95% CI = 0.56–1.15; p-value = 0.23).
Conclusions
The prognostic value of TERT promoter mutation may be modulated by MGMT methylation status. Not all MGMT-methylated GBM patients may benefit from TMZ; it is possible that only TERT-mutated GBM with MGMT methylation, in particular, may respond.
The Influence of Training Outcome and Competency on Effective Utilization of Malaria Microscopy Result by Health Professionals In South Eastern Nigeria
Authors: Okoro Chinyere Ihuarulam , Ihenetu Francis Chukwuebuka , Dunga Kingsley Excel , Achigbu Kingsley , Ejiogu Ikechukwu V , Obasi Chidera C. , Okoro Oluchi I. , Okoro Chigozie O. , Anikwo Emeka S. 
Published: July 2020

Abstract
BackgroundMalaria diagnosis in Nigeria was largely done based on clinical presentations until recently when the policy on parasitological confirmation of all suspected malaria cases before treatment was released by the government in 2011. One of the possible causes of over-diagnosis and over treatment of malaria in Nigeria is poor utilization of Malaria test results in health care delivery. This study demonstrates the influence of in-service training on malaria microscopy amongst medical laboratory scientists on the utilization of malaria microscopy results in a selected Government Health Facility in Nigeria.MethodThe base line study was conducted in 2014 while a follow up study where pre tested questionnaire on perception and utilization of malaria microscopy results by Health care providers in malaria case management were administered to end users of laboratory results in selected secondary health facilities; Basic malaria microscopy training was subsequently conducted for medical laboratory scientists working in these selected facilities in accordance with the World Health Organization (WHO) basic microscopy training manual. The training was followed up by a supportive supervision visit to the Medical Laboratories where other factors that can adversely affect microscopy results such as the necessary equipment and reagents for staining and visualization, good working conditions were addressed and put in place by the participating health facilities.Furthermore, During the basic and refresher training, Test scores was extracted using Microsoft Office Excel® 2010 template; data was cleaned and exported to Stata 11, Stata Corp. 2009. Stata Statistical Software: Release 11. College Station, TX: Stata Corp LP for data analysis. To assess the performance after the training intervention, paired-test was used to determine if there was any significant difference between the performance scores before and after the training and between the basic and refresher training.ResultThe study demonstrates a significant improvement in both the basic and refresher training mean parasite detection pre-and post-tests scores from 56.3% (95% CI 53.6-58.8%) to 77.7% (95% CI 74.4-80.2%) and 76.7 (95% CI 74.2-79.2%) to 91.2% (95% CI 88.3-94.1%)(P< 0.001). Comparing the baseline and follow up study, and the assessment of facilities’ malaria test request and utilization pattern within the study period,there was significant difference when comparing the rate of utilization of malaria result from the trained Medical Laboratory Scientists (p< 0.001).ConclusionThe increase in utilization of malaria microscopy result for effective case management of malaria in the study area was influenced by training outcome and competency of Medical Laboratory Scientists.
Application of a three-dimensional high-definition exoscope in minimally invasive transforaminal lumbar interbody fusion
Authors: Yao Zhi-Peng , Xiong Chen-Jie , Huang Bi-Wang , Yao Ya-Wei , Kang Hui , Xu Feng 
Published: July 2020

Abstract
Background

Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is becoming increasingly popular in the treatment of lumbar degenerative diseases. Microscope assisted MIS-TLIF was also reported favorable clinical outcomes and low complication rates, while limitations can include depth of field, illumination, and ergonomics. The exoscope has been introduced as an alternative to microscopes. In this report, we describe the application of the 3-dimensional (3D), high-definition (HD) exoscope for MIS-TLIF, and discuss its advantages and disadvantages.
Methods

Six patients were performed 3D-HD exoscope-assisted MIS-TLIF from September 2019 to December 2019. The exoscope was used [Kestrel View II, WEALTH CONCORD MITAKA MEDICAL TECHNOLOGIESCO., LTD. OF SHANGHAI, CHINA] during soft tissue dissection, discectomy, decompression, and cage insertion.
Results

The exoscope provided an excellent 3D view of the surgical field and allowed us to effectively and safely perform the surgical steps. All 6 patients experienced excellent surgical outcomes. The main advantages of the 3D exoscope include the possibility to provide excellent, magnified, and illuminated 3D-HD images of the surgical field to the entire operating room and serving as an excellent training tool.
Conclusion

We believe that the 3D exoscope will be a safe and effective tool to perform MIS-TLIF.
Antibiotic Use, Disposal and Awareness of Human Health Risk Associated With Consuming Antibiotics in Groundwater Among People Living in Informal Settlements of Kisumu, Kenya
Authors: Karimi Kellen Joyce , A. Aijaz , A.G. Duse , M. Mwanthi A. , R. Ayah 
Published: July 2020

Abstract
Background: Informal settlements across SSA have proliferated with increased urban population. Characterized by inadequate water supply, inhabitants resort to groundwater for domestic use. This happens oblivious of water contamination with emerging contaminants in form of antibiotics and their derivatives. Development of antibiotic resistant genes and antibiotic resistant bacteria, causes ill health, thus interventions that increase level of awareness of health effects of consuming water contaminated with antibiotics are requisite. This involves protecting human, animal and environmental in totality in a One-Health approach. This study sought to determine antibiotic use, disposal and level of awareness of health effects associated with consuming water contaminated with antibiotics.Methods: A cross-sectional study of a random sample of 447 households in selected informal settlements of Kisumu County, Kenya was conducted in September 2019. A structured questionnaire was generated based on research questions and administered to heads of households to assess, antibiotic use, disposal and level of awareness of health effects associated with consuming water contaminated with antibiotics. Data was entered and analyzed in SPSS version 20.Results: Level of awareness of health effects of consuming water contaminated with antibiotics was low, 35% (n=156), especially among households where a member had used an antibiotic within one month prior to the time of study; p=0.03. Groundwater was used by 99.8% (n=446) for various purposes, including drinking (9% (n=40)), cooking (18%(n=43)), washing utensils (79% (n=353)), clothes (96% (427)) and house (95% (421)). About half the households reported antibiotic use 43% (n=193). Among this, 74% (n=144) consulted a health worker in a healthcare facility for prescription. Respondents who had taken antibiotics did not always complete doses but reported to have kept the remainder for next time they would get sick (54%). About 32% disposed remainder of antibiotics in pit latrines, compost pits (10%) while 4% reported to have burnt them. Conclusion and recommendation:Groundwater is the major water source for domestic use in informal settlements. With low awareness of risks associated with consuming water contaminated with antibiotics, a looming public health concern due to antibiotic resistance necessitate attention to avert health effects that may lead to ill health.
Diagnostic model incorporating clinicopathological characteristics of Delphian lymph node metastasis risk profiles in papillary thyroid cancer
Authors: Li Xingchen , Duan Yuansheng , Liu Dandan , Liu Hongwei , Zhou Mengqian , Yue Kai , Shuai Yanjie , Wang Yu , Jing Chao , Wu Yansheng , Wang Xudong 
Published: July 2020

Abstract
Background

Delphian lymph node (DLN), also known as prelaryngeal node, is the component of central lymph node (Level VI). DLN has been well studied in laryngeal cancer while less in papillary thyroid cancer (PTC). However, increasing attention has been payed to its clinical value in PTC lymph node metastasis. The aim of this study was to assess the clinicopathologic risk factors for DLN metastasis and to calibrate an informative diagnosis model for predicting risk stratification in DLN metastasis.
Methods

Retrospectively analysis 936 PTC patients who underwent thyroidectomy by a single surgeon, in the department of Head and Neck Surgery of Tianjin Cancer Hospital from 2017 to 2019. Moreover, 250 PTC patients underwent thyroidectomy by another surgeon at Tianjin Cancer Hospital between January 2019 and April 2019 were used as a validation cohort. Univariate analysis and multivariable logistic regression were used to identify clinicopathologic risk factors associated with DLN metastasis. A diagnostic model was generated using logistic regression, and internal validation and external validation were also performed. Predictive performance was assessed using area under the receiver operating characteristic curve (AUROC) and calibration plot. A nomogram plot was drawn to predict individual risk based on the diagnosis prediction model.
Results

In 936 cases, 581 (62.1%) show DLN, and 177 (177/581,30.5%) were verified metastasis. DLN metastasis was significantly associated with gender, age, tumor size, bilateral cancer, multifocality, extrathyroidal extension, lymphovascular invasion and central and lateral neck lymph node metastasis. Multivariate analysis revealed that age, gender, tumor size, extrathyroid extension, lymphovascular invasion and central lymph node metastasis were independent risk factor of DLN metastasis. The nomogram included age, gender, tumor size, extrathyroid extension, lymphovascular invasion and central lymph node metastasis, and all these features had a specificity of 100%. Particularly, tumor size was the best single predictor. The diagnostic model had an area under the curve (AUC) of 0.829 (95% confidence interval, 0.804–0.854). Internal and external validation of nomogram was 0.819 and 0.745, respectively.
Conclusions

DLN metastasis appears to be an important parameter that predict metastatic disease of the central compartments. To assess DLN metastasis in more precise criterions, has great clinical significance for PTC treatment selection.