bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing relational dialectics on actor engagement in the social media ecosystem
Authors: Tsiotsou Rodoula H. 
Published: January 2021

Purpose
The purpose of this paper is to provide an in-depth understanding of actor engagement (AE) on social media by proposing a holistic and integrative conceptual framework.

Design/methodology/approach
Based on a sample of 118 articles, the paper draws on the service-dominant logic (SDL)-based service ecosystem perspective combined with the tenets of relational dialectics as theoretical lenses to inform AE research in social media.

Findings
The paper proposes a framework of AE in social media called the TASC model, an acronym of Thesis-Antithesis-Synthesis-Conflict. TASC introduces the dialectical nature of AE and discusses the contexts and levels of AE in the social media ecosystem and their evolving processes.

Practical implications
Firms can apply the knowledge provided by TASC to gather marketing intelligence and develop marketing strategies to anticipate tensions, motivate the desired AE intensity and valence and reinforce value co-creation in the social media ecosystem.

Originality/value
TASC is a comprehensive framework that, for the first time, explains engagement at all levels of the social media ecosystem by combining the SDL-based service ecosystem view with the relational dialectics perspective.
Ethics disclosure as strategy: a longitudinal case study
Authors: Kumarasinghe Sriyalatha , Peiris Indujeeva Keerthilal , Everett André M. 
Published: January 2021

PurposeThis study investigates how a globally-oriented, developing country enterprise formulates and implements ethics strategies, policies and behaviours with respect to its stakeholders, and how the case company discloses and utilises its ethics strategies, policies and behaviours to gain competitive advantage and create stakeholder value.Design/methodology/approachA longitudinal single case study is presented featuring a tea producer and marketer in Sri Lanka, one of the country’s largest exporters, that is targeting a global consumer market. Applying Spiller’s (2000) framework for ethical business practices, this research analyses data collected in a series of interviews in combination with content analysis of company annual reports and sustainability reports covering 2010 to 2019 supplemented by on-site observation.FindingsAnalysis reveals that the company maintains ethical strategies, policies and behaviours with respect to its prominent stakeholders, and strategically discloses those practices. The firm’s proactive disclosures of its business and sustainability ethics practices enabled it to establish and sustain competitive advantage over its competitors. The findings are discussed in light of their theoretical and practical implications, identifying areas for future studies.Originality/valueThis is the first ethics study to include both longitudinal documentary analysis and personal interviews in a single case study based in Sri Lanka. It contributes to discussion regarding balancing ethics and sustainability as parts of business strategies for reputation building and value creation through identifying salient stakeholders and ethics-based non-financial disclosures by contemporary business organisations.
The concept of 3D ECT system with increased border area sensitivity for crystallization processes diagnosis
Authors: Wajman Radosław 
Published: January 2021

Purpose
Crystallization is the process widely used for components separation and solids purification. The systems for crystallization process evaluation applied so far, involve numerous non-invasive tomographic measurement techniques which suffers from some reported problems. The purpose of this paper is to show the abilities of three-dimensional Electrical Capacitance Tomography (3D ECT) in the context of non-invasive and non-intrusive visualization of crystallization processes. Multiple aspects and problems of ECT imaging, as well as the computer model design to work with the high relative permittivity liquids, have been pointed out.

Design/methodology/approach
To design the most efficient (from a mechanical and electrical point of view) 3D ECT sensor structure, the high-precise impedance meter was applied. The three types of sensor were designed, built, and tested. To meet the new concept requirements, the dedicated ECT device has been constructed.

Findings
It has been shown that the ECT technique can be applied to the diagnosis of crystallization. The crystals distribution can be identified using this technique. The achieved measurement resolution allows detecting the localization of crystals. The usage of stabilized electrodes improves the sensitivity of the sensor and provides the images better suitable for further analysis.

Originality/value
The dedicated 3D ECT sensor construction has been proposed to increase its sensitivity in the border area, where the crystals grow. Regarding this feature, some new algorithms for the potential field distribution and the sensitivity matrix calculation have been developed. The adaptation of the iterative 3D image reconstruction process has also been described.
Toward dynamic capability views of entrepreneurial growth intention: perspective of floricultures industry in Sri Lanka
Authors: Sachitra Vilani , Padmini Chandra 
Published: January 2021

PurposeIt is aware that entrepreneurial growth has gained some attention in the literature, yet the debate in respect of the determinants of entrepreneurial growth intention (EGI) is far from being complete. The purpose of this study is to identify the key dynamic capabilities that foster EGI in floriculture industry in Sri Lanka.Design/methodology/approachThe study used quantitative approach. The owners of farms who possess commercial experience in floriculture cultivation in Sri Lanka were selected as a target population. A self-administrated structured questionnaire was used to collect data. Valid and reliable indicators were developed to conceptualize five key capabilities and EGI.FindingsBased on the responses from 206 farm owners, results of the multiple regression analysis indicate that organizational learning, technological and alliance formation capabilities are significantly associated with EGI of floriculture farm owners.Originality/valueThe need for common conceptualization of dynamic capabilities and EGI represents a major gap in the literature. The study expands the current debates on entrepreneurial growth and institutional environment, which allows the mapping out of dynamic capability development.
Ending youth unemployment in sub‐saharan Africa: Does ICT development have any role?
Authors: Metu Amaka G. , Ajudua Emmanuel , Eboh Ifeoma , Ukeje Chimezie , Madichie Chekwube 
Published: January 2021

AbstractThis study investigates the role of information and communication technology (ICT) development towards ending youth unemployment in the 48 sub‐Saharan Africa (SSA) countries from 1991 to 2018. Using a dynamic panel modelling technique, the study employed the instrumental variable (IV) regression, within the framework of the system generalized method of moment (GMM‐SYS) estimator. The results show that the low level of mobile phone subscriptions, broadband internet subscriptions, Wi‐Fi internet subscriptions and internet bandwidth exert a significant negative effect on youth unemployment. This means that ICT development reduces youth unemployment in SSA. Also, it was found that the number of households with access to computers has a negative but insignificant effect on youth unemployment; this shows the ineffective role of household computers in reducing youth unemployment in SSA. Based on these findings, we recommend among other things that, for government to optimize the expanding youth population, there is the need for further telecommunication reforms to reduce the cost of mobile phone technologies and improved ultra‐modern internet facilities in the region.
The impact of outbound foreign direct investment on export and private investment: Comparative analysis of emerging and developed countries
Authors: Hasanat Shah Syed , Ameer Waqar 
Published: January 2021

AbsractOutbound foreign direct investment (OFDI) was traditionally the realm of developed countries. However, recently OFDI originating from emerging countries has increased rapidly but hardly any study noticed its impact on the economic activities in emerging source countries. Therefore, this study explores the impact of OFDI on exports and private investment in emerging source countries by employing cross‐sectional dependence autoregressive distributed lag model. The findings in this paper suggest that OFDI contributes significantly to exports in the emerging countries both in the long and in the short run; however, OFDI contribution to private investment in emerging countries is limited to long run only. Moreover, the findings suggest that the positive impact of OFDI on exports and private investment in emerging countries requires quality institutions. The positive impact of OFDI on exports and private investment in emerging countries is low when compared with developed countries. However, the significant and high values of a dummy variable for the 2007–2008 financial crisis show that emerging countries are converging on developed countries in terms of gains from OFDI in post‐crisis era. We find that OFDI is an effective policy tool for emerging countries to diversify and kick start the local economy.
BACH2‐mediated FOS confers cytarabine resistance via stromal microenvironment alterations in pediatric ALL
Authors: Zhang Han , Zhang Ruidong , Zheng Xueling , Sun Ming , Fan Jia , Fang Chunlian , Tian Xin , Zheng Huyong 
Published: January 2021

AbstractAcute lymphoblastic leukemia (ALL) is an aggressive hematological cancer that mainly affects children. Relapse and chemoresistance result in treatment failure, underlining the need for improved therapies. BTB and CNC homology 2 (BACH2) is a lymphoid‐specific transcription repressor recognized as a tumor suppressor in lymphomas, but little is known about its function and regulatory network in pediatric ALL (p‐ALL). Herein, we found aberrant BACH2 expression at new diagnosis not only facilitated risk stratification of p‐ALL but also served as a sensitive predictor of early treatment response and clinical outcome. Silencing BACH2 in ALL cells increased cell proliferation and accelerated cell cycle progression. BACH2 blockade also promoted cell adhesion to bone marrow stromal cells and conferred cytarabine (Ara‐C)–resistant properties to leukemia cells by altering stromal microenvironment. Strikingly, we identified FOS, a transcriptional activator competing with BACH2, as a novel downstream target repressed by BACH2. Blocking FOS by chemical compounds enhanced the effect of Ara‐C treatment in both primary p‐ALL cells and pre‐B‐ALL–driven leukemia xenografts and prolonged the survival of tumor‐bearing mice. These data highlight an interconnected network of BACH2‐FOS, disruption of which could render current chemotherapies more effective and offer a promising therapeutic strategy to overcome Ara‐C resistance in p‐ALL.
lnc‐RHL, a novel long non‐coding RNA required for the differentiation of hepatocytes from human bipotent progenitor cells
Authors: Prabhakar Bindu , Lee Soowan , Bochanis Adara , He Wu , Manautou José E. , Rasmussen Theodore P. 
Published: January 2021

AbstractObjectivesThe final stage of liver development is the production of hepatocytes and cholangiocytes (biliary epithelial cells) from bipotent hepatic progenitor cells. We used HepaRG cells, which are bipotent and able to differentiate into both hepatocytes and cholangiocytes, as a model to study the action of a novel lncRNA (lnc‐RHL) and its role in the regulation of bipotency leading to hepatocytes and cholangiocytes.Materials and MethodsDifferentiation of HepaRG cells was assessed by marker expression and morphology which revealed their ability to differentiate into hepatocytes and cholangiocytes (modelling the behaviour of hepatoblasts in vivo). Using a qRT‐PCR and RACE, we cloned a novel lncRNA (lnc‐RHL; regulator of hepatic lineages) that is upregulated upon HepaRG differentiation. Using inducible knockdown of lnc‐RHL concurrently with differentiation, we show that lnc‐RHL is required for proper HepaRG cell differentiation resulting in diminution of the hepatocyte lineage.ResultsHere, we report the discovery of lnc‐RHL, a spliced and polyadenylated 670 base lncRNA expressed from the 11q23.3 apolipoprotein gene cluster. lnc‐RHL expression is confined to hepatic lineages and is upregulated when bipotent HepaRG cells are caused to differentiate. HepaRG cells made deficient for lnc‐RHL have reduced ability to differentiate into hepatocytes, but retain their ability to differentiate into cholangiocytes.ConclusionsDeficiency for lnc‐RHL in HepaRG cells converts them from bipotent progenitor cells to unipotent progenitor cells with impaired ability to yield hepatocytes. We conclude that lnc‐RHL is a key regulator of bipotency in HepaRG cells.
Population biology and phenology of the colour polymorphic damselfly Ischnura elegans at its southern range limit in Cyprus
Authors: Willink Beatriz , Blow Rachel , Sparrow David J. , Sparrow Rosalyn , Svensson Erik I. 
Published: January 2021

1. Geographically widespread species provide excellent opportunities to investigate how phenotypes change across large‐scale environmental gradients. Temperature is a fundamental environmental variable and an important determinant of insect fitness. However, field research is often geographically restricted, and typically concentrated in northern latitudes. Basic population biology and phenotypic clines in relation to temperature therefore remain poorly known across the entire geographic range, even in otherwise well‐studied taxa.2. We surveyed populations of the trimorphic damselfly Ischnura elegans in Cyprus, which is the southern range limit in Europe of this widespread insect species. Females of I. elegans occur in three discrete and heritable colour morphs, which vary in suites of phenotypic traits. One of these female morphs is a male‐mimic that avoids excessive male‐mating harassment by its male‐like appearance, and which is more cold‐tolerant than the two other morphs.3. In contrast to the situation in northern Europe, these male‐mimicking females are the minority morph in Cyprus, representing only about 5% of all females. Male mimics also have lower mating rates than alternative female morphs.4. Individuals in Cyprus are relatively small in comparison to the reported European range for body size, consistent with Bergman's rule.5. Finally, populations of I. elegans on the island have the longest flight period known in Europe, and there is only partial evidence for seasonality in flight activity.6. These results underscore the benefits of considering the entire range of environmental conditions encountered by insect species when conducting evolutionary ecology research.
A systematic mapping review of interventions to improve adolescent mental health literacy, attitudes and behaviours
Authors: Patafio Brittany , Miller Peter , Baldwin Ryan , Taylor Nicholas , Hyder Shannon 
Published: January 2021

AbstractAimThe onset of mental illness is most common in adolescence, therefore mental health promotion efforts frequently target this age group. Evaluation literature in this area is largely segmented into specific domains in terms of settings, countries, and/or groups of young people, but an overall understanding and comparison across these areas is lacking. The current review aims to provide such an overview of interventions/programs which attempt to improve adolescents' mental health literacy, attitudes/stigma and behaviours.MethodsA systematic mapping review synthesized the strengths and weaknesses of published interventions/programs to improve mental health outcomes in youth. Ten databases and grey literature sources were searched, and results were categorized according to sample, location/setting, type of information presented, delivery and testing procedures, mental health outcome/s evaluated, and limitations.ResultsOne hundred and forty articles met the inclusion criteria; 126 were original records and 14 were reviews. Mental health literacy and attitudes/stigma were examined most frequently, and studies were predominantly conducted in school‐based environments and high income economies. Intervention/program effectiveness varied across outcome/s measured, setting, and control group usage, with mental health literacy exhibiting the most positive changes overall. Common limitations included no long‐term follow up or control group inclusion.ConclusionsDespite generally positive changes seen throughout studies in this area, effectiveness differed across a range of methodological domains. Most research is conducted in schools and higher income economies, but the lack of investigation in other contexts (i.e., internet or community) or lower income countries suggests our understanding in this area is constrained.
Molecular regulation of brain metabolism underlying circadian epilepsy
Authors: Chan Felix , Liu Judy 
Published: January 2021

AbstractExtensive study has demonstrated that epilepsy occurs with greater frequency at certain times in the 24‐h cycle. Although these findings implicate an overlap between the circadian rhythm and epilepsy, the molecular and cellular mechanisms underlying this circadian regulation are poorly understood. Because the 24‐h rhythm is generated by the circadian molecular system, it is not surprising that this system comprised of many circadian genes is implicated in epilepsy. We summarized evidence in the literature implicating various circadian genes such as Clock, Bmal1, Per1, Rev‐erb⍺, and Ror⍺ in epilepsy. In various animal models of epilepsy, the circadian oscillation and the steady‐state level of these genes are disrupted. The downstream pathway of these genes involves a large number of metabolic pathways associated with epilepsy. These pathways include pyridoxal metabolism, the mammalian target of rapamycin pathway, and the regulation of redox state. We propose that disruption of these metabolic pathways could mediate the circadian regulation of epilepsy. A greater understanding of the cellular and molecular mechanism of circadian regulation of epilepsy would enable us to precisely target the circadian disruption in epilepsy for a novel therapeutic approach.
Validating care‐needs level against self‐reported measures of functioning, disability and sarcopenia among Japanese patients receiving home medical care: The Zaitaku Evaluative Initiatives and Outcome Study
Authors: Tsugihashi Yukio , Hirose Misaki , Iida Hidekazu , Hayashi Shinu , Yasunaka Masakazu , Shirahige Yutaka , Kurita Noriaki ,   the ZEVIOUS group
Published: January 2021

AimThis study aimed to examine the validity of the care‐needs levels classified in Japan's long‐term care insurance system (LTCI‐CNLs) when compared with patients’ self‐perceived functioning, disability and physical performance among patients receiving home medical care.MethodsThis was a multicenter cross‐sectional study in Japan. Patients who were receiving continuous home medical care and who could respond to the questionnaire were enrolled in this study. In addition to the LTCI‐CNLs, the 12‐item version of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) and the SARC‐F were used to measure functioning, disability and physical performance (sarcopenia). In addition, correlations and associations of the LTCI‐CNLs with the WHODAS 2.0 and SARC‐F were analyzed using Spearman correlations and linear mixed models.ResultsData from 181 patients were included in the analyses. The LTCI‐CNLs varied, ranging from support level 1 (5.5%) to care‐needs level 5 (10.5%), with care‐needs level 2 being the most prevalent (24.9%). Moderate correlations of the LTCI‐CNLs with the WHODAS 2.0 and SARC‐F were found (ρ = 0.58 and 0.44, respectively). Although WHODAS 2.0 and SARC‐F scores varied within each LTCI‐CNL, predicted WHODAS 2.0 and SARC‐F scores increased as LTCI‐CNL increased. Dementia was not associated with WHODAS 2.0 or SARC‐F.ConclusionsThe LTCI‐CNLs was associated with self‐reported functioning, disability and physical performance among home medical care patients. Future studies can use the LTCI‐CNLs as an outcome variable for specific care approaches or as a proxy covariate for casemix status. Geriatr Gerontol Int 2021; 21: 229–237.
Kihon Checklist to assess frailty in older adults: Some evidence on the internal consistency and validity of the Spanish version
Authors: Sentandreu‐Mañó Trinidad , Cezón‐Serrano Natalia , Cebrià i Iranzo Maria Angels , Tortosa‐Chuliá Maria A , Tomás José M , Salom Terrádez José Ricardo , Balasch‐Bernat Mercè 
Published: January 2021

AimThe aim of this study was to assess the internal consistency, hypothesis testing and criterion‐related validity of the Spanish versions of the Kihon Checklist (KCL) – the original 25‐item and reduced 15‐item versions – for screening frailty in community‐dwelling older adults.MethodsA cross‐sectional study was carried out between March and September 2018 in Valencia province (Spain). A sample of 251 participants was recruited. Construct validity was assessed using four different frailty instruments, and alternative measures corresponding to the KCL domains (handgrip strength, gait speed, the Short Physical Performance Battery, skeletal muscle mass index, physical activity level, functional status, cognitive function, depressive mood, health‐related quality of life and nutritional status). Fried's Frailty Phenotype was used to evaluate criterion validity.ResultsInternal consistency assessed with Kuder–Richardson Formula had a value of 0.69 for the 25‐item version, slightly lower than the usual 0.7 for considering good reliability, and 0.71 for the 15‐item version. There were significant correlations between KCL versions and Fried's Frailty Phenotype, Edmonton Scale, Tilburg Indicator and FRAIL Scale. Consistent significant correlations were also obtained with all frailty measurements and instrumental activities of daily living, physical strength, eating, socialization, and mood domains of the KCL. The KCL closely correlated with other standardized measurements of physical function, cognitive function, depressive mood, and health‐related quality of life. The KCL also showed satisfactory diagnostic accuracy for frailty (area under the curve 0.891 for KCL‐25; area under the curve 0.857 for KCL‐15). The optimal cut‐off points were 5/6 and 3/4, respectively.ConclusionsThe findings suggest that both versions of the KCL, especially KCL‐15, showed adequate evidence of validity and internal consistency as a preliminary screening of frailty among community‐dwelling older adults in Spain. Geriatr Gerontol Int 2021; 21: 262–267.
Formation of nano‐ZrO2 by laser surface treatment of ZrB2‐SiC–based composite
Authors: Das Jiten , Vajjala Srinivas , Tak Manish , Jabbireddy Janardhana Reddy , Velidandla Venkata Bhanu Prasad 
Published: January 2021

AbstractThis study aims at reducing the oxidation by forming a prior‐protective‐oxide scale by laser‐surface‐treatment of two ZrB2‐SiC based composites namely ZrB2‐20v/oSiC‐2v/oB4C‐0.24v/oCf (ZSC) and ZrB2‐20v/oSiC‐2v/oB4C (ZS). ANSYS 15.0 was used to determine laser processing regime. Rigorous theoretical calculations provided temperature distribution, laser parameters and resulting laser power densities required to produce tetragonal ZrO2. Both the theoretical prediction as well as experimentation show that the laser‐surface‐treatment with the laser power densities of 31.85 and 56.61 W/mm2 for 20 and 30 s render formation of nano‐tetragonal‐ZrO2 (100–130 nm) at room temperature (RT). Morphology and size of the nano‐tetragonal‐ZrO2 grains depends on the laser exposure time. Nano‐grain size helps in stabilizing tetragonal ZrO2 phase at RT without the need of Y2O3 addition. Nano‐tetragonal‐ZrO2 may facilitate better ability for pegging, prevent scale‐spallation and act as thermal barrier coating (TBC).