bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chaotic global analysis of heart rate variability following power spectral adjustments during exposure to traffic noise in healthy adult women
Authors: Garner D. M. , Alves M. , Da Silva B. P. , De Alcantara Sousa L. V. , Valenti V. E. 
Published: July 2020

Aim. Previous studies have described the substantial impact of different types of noise on the linear behaviour of heart rate variability (HRV). Yet, there are limited studies about the complexity or nonlinear dynamics of HRV during exposure to traffic noise. Here, we evaluated the complexity of HRV during traffic noise exposure via six power spectra and, when adjusted by the parameters of the Multi-Taper Method (MTM).Material and methods. We analysed 31 healthy female students between 18 and 30 years old. Subjects remained at rest, seated under spontaneous breathing for 20 minutes with an earphone turned off and then the volunteers were exposed to traffic noise through an earphone for a period of 20 minutes. The traffic noise was recorded from a busy urban street and the sound involved car, bus, trucks engineers and horn sounds (71-104 dB).Results. The results stipulate that CFP3 and CFP6 are the best metrics to distinguish the two groups. The most appropriate power spectra were, Welch and MTM. Increasing the DPSS parameter of MTM increased the performance of both CFP3 and CFP6 as mathematical markers. Adaptive was the preferred type for Thomson’s nonlinear combination method.Conclusion. CFP3 with the adaptive option for MTM, and increased DPSS is designated as the best mathematical marker on the basis of five statistical tests.
Cardioprotective diet: prevalence, associations and prevention reserves
Authors: Karamnova N. S. , Maksimov S. A. , Shalnova S. A. , Shvabskaya O. B. , Drapkina O. M. 
Published: July 2020

Most traditional risk factors for cardiovascular disease (CVD) are diet dependent and are caused by an imbalanced nutrition. A healthy diet and individual eating habits have a significant protective effect against CVD.Aim. To study the prevalence of dietary habits with protective effects against CVD in the adult population.Material and methods. The analysis was performed using data of representative samples in 13 Russian regions of male and female population aged 25-64 years (n=19520; men — 7329, women — 12191). The response rate was about 80%. The diet was assessed by the frequency of consumption of certain foods. The cardioprotective diet included: daily consumption of vegetables and fruits, weekly — fish products, the use of only vegetable oils in cooking, and consumption of low-fat dairy. The presence of all 4 eating habits was considered Ideal Diet (ID), 1-3 habits — Intermediate Diet (ImD), none of listed habits — Bad Diet (BD).Results. The ImD was the most common — 85,8%. However, there were slight regional differences — from 80,1% in the Ivanovo Oblast to 91,0% in the Tyumen Oblast (p<0,001). The prevalence of ID was 7,0%; more common — among women (p<0,001), urban residents (p<0,001), people with higher education (p<0,001) and unemployed participants (p=0,016). It increases with age (p<0,001). The highest rate of ID was noted in St. Petersburg (13,8%) and Primorsky Krai (10,5%), the lowest — in the Volgograd (3,6%) and Tyumen Oblasts (3,5%), in the Republic of North Ossetia (3,4%). BD was more common in men (p<0,001), among people aged 25-34 years (p<0,001), less educated (p<0,001) and low-income (p<0,001) people. The prevalence of BD in the general population was 7,2% and varies from 3,1% in the Voronezh Oblast to 13,6% in the Volgograd Oblast. Individuals with hyperglycemia (50%), abdominal obesity (20%) and general obesity (18%), dyslipidemia (15%) and history of CVD (22%) were more likely to have ID. Persons with hyperglycemia (17%), abdominal obesity (13%), general obesity (11%), dyslipidemia (8%) and history of CVD (9%) were more likely to have ImD.Conclusion. A low prevalence of cardioprotective diet in the population was revealed. Only individual habits are widespread; however, a small part of Russians follow all cardioprotective habits.
Association of hemodynamic parameters and cardiovascular risk factors with cardiac remodeling in young patients with prehypertension and hypertension
Authors: Antropova O. N. , Silkina S. B. , Polyakova I. G. , Perevozchikova T. V. 
Published: July 2020

Aim. To assess the prevalence of left ventricular (LV) remodeling and identify its association with hemodynamic parameters and cardiovascular risk factors in young patients with prehypertension (preHTN) and hypertension (HTN).Material and methods. Group 1 (n=47) included patients with preHTN, group 2 (n=65) — patients with untreated HTN (age — 25-44 years). We performed 24-hour ambulatory blood pressure (BP) monitoring using a BpLAB monitor (OOO Petr Telegin). Echocardiography was carried out using a EnVisorC ultrasound system (Philips, Netherlands). Statistical analysis was performed using the software package Microsoft Excel 2010.Results. We revealed that 2,4% and 17,0% (p=0,002) of patients with preHTN and HTN had LV concentric remodeling, respectively; LV hypertrophy was recorded in 9,5% and 12,0% of patients, respectively. In group 1, a moderate positive relationship was found between the ratio of early to late peak velocities (E/A) and the average 24-hour aortic BP (r=0,66, p<0,05) was revealed. We also identified correlation of the augmentation index with the LV mass index (LVMI) (r=0,57, p<0,05) and LV relative wall thickness (RWT) (r=-0,7, p<0,05). In hypertensive patients, a correlation of LVMI and left atrial dimensions with a decrease in peripheral systolic blood pressure (SBP) and diastolic blood pressure (DBP) at night was found. A correlation of average 24-hour aortic BP and E/A (r=0,58, p<0,05), LV posterior wall thickness (r=0,53, p<0,05) and LV end-diastolic volume (r=0,45, p<0,05) was also revealed. A direct effect of BMI, waist circumference, uric acid values on echocardiographic data in patients with preHTN and HTN was detected.Conclusion. Despite the age, young patients with preHTN and HTN can have LV concentric remodeling and hypertrophy. LV geometry is correlated with obesity and uric acid values; in preHTN patients — with vascular stiffness and 24-hour aortic BP, in HTN patients — with 24-hour central and peripheral BP.
Fixed-dose combination of amlodipine/indapamide/perindopril arginine — a rational and safe choice for blood pressure control in actual clinical setting: data of an observational program DOKAZATEL`STVO
Authors: Kobalava J. D. , Tolkacheva V. V. , Troitskaya E. A. , Kolesnikova I. A. , Markova M. A. 
Published: July 2020

Aim. To analyze the efficacy and tolerability of amlodipine/indapamide/perindopril arginine (Triplixam) in a subgroup of 790 people participating in the Russian observational program DOKAZATEL`STVO without use of other antihypertensive agents.Material and methods. The analysis included 790 patients with hypertension (HTN) (men — 37,9%, mean age — 60,0±10,2 years). The drug was administrated in one of 4 recommended dosages for 3 months. We assessed the dynamics of office and home blood pressure (BP) from visit 1 to visit 4 and the frequency of achieving the target BP <140/90 mm Hg in 3 months.Results. After 3 months, office systolic BP (SBP) decreased from 163,4±14,0 to 127,2±7,8 mm Hg, diastolic BP (DBP) — from 95,7±9,5 to 78,3±6,2 mm Hg (p 0,001). Home SBP in the morning decreased from 145,9±12,3 to 128,3±7,8 mm Hg, DBP — from 86,2±7,7 to 78,4±5,6 mm Hg (p<0,001). After 3 months, target office BP (<140/90 mm Hg) was achieved in 88,4% of subjects, home BP (<135/85 mm Hg) — 73%.Conclusion. The administration of Triplixam without additional antihypertensive agents results in a significant BP decrease by 36/17 mm Hg and rapid achievement of BP control in most patients. The combination is safe and well tolerated.
The prevalence of traditional risk factors for cardiovascular disease in the Omsk region: data of the ESSE-RF2 study
Authors: Viktorova I. A. , Shirlina N. G. , Stasenko V. L. , Muromtseva G. A. 
Published: July 2020

Aim. To study the prevalence of some traditional risk factors for cardiovascular disease (CVD) in the Omsk region.Material and methods. The prevalence of traditional risk factors for CVD in a representative sample of the Omsk region population aged 25-64 years (n=1,648) was estimated as a part of the ESSE-RF2 study in 2017.Results. It was established that the mean age of CVD detection in the Omsk region is 46,3 years, the prevalence of overweight is 35,0%, obesity — 30,3%. Abdominal obesity was detected in 56,8% of subjects. Smoking was reveled in 21,2% of the population, former smoking — 20,0%. Alcohol consumption more than 2 times a month was observed in one third of respondents (30,5%). In the group of healthy people, compared with CVD patients, the percentage of smokers and alcohol consumers was detected significantly more often: smoking — 25,2±1,26% vs 17,1±0,86% and 32,9±1,6% vs 28,1±1,4%, respectively. Perhaps it was the diseases the reason for smoking cessation and alcohol abstinence among people with CVD. It should be noted that among 70% of alcohol consumers, both with/ without CVD, strong drinks were the preferred type of alcohol. Hypertension (HTN) was observed in 47,9% of subjects, and in 43,1% the diagnosis was verified. In 4,8% of HTN individuals, blood pressure increase was detected for the first time in this study. The prevalence of diabetes of both types in the Omsk region was 6,7%, and in group A (with CVD) it was much higher than in group B (without CVD): 10,7% vs 2,8%. Type 2 diabetes prevailed in people with CVD (p=0,000005). This was not characteristic of type 1 diabetes.Conclusion. The most common risk factors for CVD in the Omsk region population were HTN (47,9%), abdominal obesity (56,8%), a positive family history of early CVD (62,0%), alcohol consumption over the past 12 months (71,7%) and strong alcohol drinking (72,0%). However, a significant portion of the subjects (41,3%) consumed alcohol no more than 1 time per month.
The prevalence of metabolic syndrome in the Krasnoyarsk Krai population and the features of its association with hyperuricemia
Authors: Grinshtein Yu. I. , Shabalin V. V. , Ruf R. R. , Shalnova S. A. 
Published: July 2020

Aim. To study the prevalence of metabolic syndrome (MS) and its components, as well as their relationship with hyperuricemia (HU) in a representative sample of the Krasnoyarsk Krai.Material and methods. As part of a multicenter epidemiological study ESSE-RF, a representative sample of 1603 residents of the Krasnoyarsk Krai aged 25-64 was randomized. All subjects underwent a questionnaire survey, anthropometry, office blood pressure (BP) measurement, determining the levels of blood lipids, plasma glucose and serum uric acid. MS was diagnosed according to the modified NCEP ATP III criteria (2005). Statistical processing was carried out using the software package IBM SPSS v 22.Results. The total prevalence of MS was 26,8%; higher in women than in men (29,4% vs 22,9%). With age, the prevalence of MS significantly increased — from 6,9% in subjects aged 25-34 years to 45,2% in people 55-64 years old. The prevalence of MS was significantly higher among rural residents compared with urban ones (36,8% vs 23,1%). Education level significantly affected prevalence of MS: in people with basic education, MS was found in 35,7%, with secondary — in 30,3%, with higher — in 17,8%. Regression analysis showed that hypertriglyceridemia, blood pressure >130/85 mm Hg and glucose ≥5,6 mmol/l were a significant predictors of HU in all subjects. For men, significant predictors of HU were hypertriglyceridemia and abdominal obesity, and for women — glucose ≥5,6 mmol/l and lipid-lowering therapy.Conclusion. The prevalence of MS in the Krasnoyarsk Krai, according to the modified NCEP ATP III criteria (2005), is 26,8%. MS is more often recorded in women than in men and in rural residents than in urban ones. With an increase in the education level, MS is less common. With age, the prevalence of MS significantly increases. The correlation of HU is not revealed with all the components of MS and has sex differences.
Erlotinib for Non-Small Cell Lung Cancer with Leptomeningeal Metastases: A Phase II Study (LOGIK1101)
Authors: Nosaki Kaname , Yamanaka Takeharu , Hamada Akinobu , Shiraishi Yoshimasa , Harada Taishi , Himeji Daisuke , Kitazaki Takeshi , Ebi Noriyuki , Shimose Takayuki , Seto Takashi , Takenoyama Mitsuhiro , Sugio Kenji 
Published: July 2020

Abstract

Lessons Learned
This phase II trial evaluated the efficacy of erlotinib for patients with non-small cell lung cancer with leptomeningeal metastasis. The 17 cerebrospinal fluid specimens that were available for epidermal growth factor receptor mutation analysis were all negative for the resistance-conferring T790M mutation. The cytological objective clearance rate was 30.0% (95% confidence interval: 11.9%–54.3%). The median time to progression was 2.2 months. The rate of cerebrospinal fluid penetration among these patients was equivalent to those in previous reports regarding leptomeningeal metastasis.

Background
Leptomeningeal metastases (LM) occur in approximately 5% of patients with non-small cell lung cancer (NSCLC) and are associated with a poor prognosis. However, no prospective study has identified an active chemotherapeutic drug in this setting.

Methods
Patients were considered eligible to receive erlotinib if they had NSCLC with cytologically confirmed LM. The objective cytological clearance rate, time to LM progression (TTP), overall survival (OS), quality of life outcomes, and pharmacokinetics were analyzed. This study was closed because of slow accrual at 21 of the intended 32 patients (66%).

Results
Between December 2011 and May 2015, 21 patients (17 with activating epidermal growth factor receptor [EGFR] mutations) were enrolled. The 17 cerebrospinal fluid specimens available were all negative for the T790M mutation, which confers erlotinib resistance. The clearance rate was 30.0% (95% confidence interval [CI]: 11.9%–54.3%), the median TTP was 2.2 months, and the median OS was 3.4 months. Significantly longer TTP and OS times were observed in patients with mutant EGFR (p = .0113 and p &lt; .0054, respectively). The mean cerebrospinal fluid penetration rate was 3.31% ± 0.77%. There was a good correlation between plasma and cerebrospinal fluid (CSF) concentrations, although there was no clear correlation between pharmacokinetic parameters and clinical outcome.

Conclusion
Erlotinib was active for LM and may be a treatment option for patients with EGFR-mutated NSCLC and LM.
An Algorithm for Computing Average Mutual Information using Probability Distribution Smoothing
Authors: Goneid Amr M.S. 
Published: July 2020

There is continuing interest in using Average Mutual Information (AMI) to quantify the pair-wise distance between dataset profiles. Among several algorithms used to find a numerical estimation of AMI, the histogram method is the most common since it provides simplicity and least cost. However, this algorithm is known to underestimate the computed entropies and to overestimate the resulting AMI. Kernel Density Estimator (KDE)-based algorithms advanced to alleviate such systematic errors rely on bin-level smoothing. In the present work, we propose an alternative algorithm that uses smoothing on the probability distribution level. We consider several smoothing functions, both in the probability space and in its frequency space. An experimental approach is used to investigate the effect of such modification on the computation of both the entropy and the AMI. Results show that, to a significant extent, the present method is able to remove systematic errors in computing entropy and AMI. It is also shown that the present algorithm leads to better reconstruction of multivariate time series when AMI is used in conjunction with their independent components.
ET-Hollow Module and ET-Lifting Module
Authors: Fandi Firas sh. , Yaseen Sahira M. 
Published: July 2020

Let M be a R-module;, where R be a commutative; ring with identity,
In this paper, we defined a new types of module namely “ET-hollow(ET-holl.) and ET-lifting(ET-lift.) modules”. An R-module M is called ET-holl. module, if for all sub-module H of M then HM. An R-module M is called An R-module M is called ET-lifting module, if for all H M , there exists X M and LM, such that H=X+L. We give many characterizations of ET-holl. and ET-lifting modules, Also we give the relation between T-hollow and ET-holl. and relation between T-lifting modules and ET-lift. modules.
IoT based Water Management System
Authors: Karhe Prof. R. R. , Kachawa Ms.Vaishali Dilip 
Published: July 2020

The conventional technique of measuring the quality of water is to gather the samples manually and send it laboratory for analysis, but this technique is time overwhelming and not economical. Since it is not feasible to take the water sample to the laboratory after every hour for measuring its quality. The water quality measuring system can measure the essential qualities of water in real time. The system consists of multiple sensors to measure the standard of water, microcontroller and wifi modem to send the information to the watching center. It's a true time system which is able to endlessly measure the standard of water and can send the measured values to the watching center when each predefinedtime.
During the past decade, water needs have increased unpredictably in India. Increasing demand of water supply has become a major challenge for the world. Wasteful usage of water, climatic changes and Urbanization has further depleted the resource. Conservation and management of the resource must be given utmost importance. In this paper, we present an IoT design for water monitoring and control approach which supports internet based data collection on real time bases. This paper proposes a system that addresses new challenges in the water sector -flow rate measuring and the need for a study of the supply of water in order to curb water wastage and encourage its conservation. We also measure the quality of water distributed to every household by deploying pH and conductivity sensors. The traditional water metering systems require periodic human intervention for maintenance making it inconvenient and often least effective. This system is designed to overcome for shortcoming of the existing models for a ubiquitous usage of wireless systems for smart quality monitoring and communicate datawirelessly.
Sensitivity and Specificity of Gold Chromatography Immuno-Assays IgM/IgG Antibody Test for COVID-19: Review of the current literature
Authors: Osman Sahar Elderdiri Gafar , Mohammed Ahmed Ehab Mohammed Elmadenah Mohammed , Hussain Nazik Elmaliaka 
Published: July 2020

Abstract:
Background: The World Health Organization recommends molecular tests (PCR) to the diagnosis of COVID-19, which detect the (SARS-CoV2) virus RNA. However, these tests are expensive and give a high negative result. There were urgent medical and public health needs for early diagnosis and treatment to minimize the spread of COVID-19. This review aimed to summarize known to date information about the latest research progress of the sensitivity and specificity of rapid combined IgM/IgG antibody test to diagnose the pandemic novel coronavirus.
Methods: The literature search was conducted using PubMed, Google Scholar, Science Direct, supplemented by (Web of Science electronic databases), with the search term (COVID19 or COVID-19, novel coronavirus, SARS CoV-2 or SARS CoV2, Rapid antibody test, IgM/IgG, sensitivity, specificity).
Results: The review included eight clinical studies for a total of 782 patients with COVID-19 and 631 healthy control. The sensitivity and specificity of Gold Chromatography Immuno-Assays (GCIAs) IgM/IgG rapid test vary greatly among published studies. The IgM/IgG sensitivity ranged from 73.9 to 89.3% in 6/8 (75%) studies and the IgM/IgG specificity ranged from 88.9 to 100% in the eight (100%) reviewed studies. The pooled data revealed that the average of sensitivity and specificity was 70% and 94.5%, respectively. They agreed on its simplicity, fastness, and fewer requirements.
Conclusion: The GCIAs IgM/IgG rapid tests are simply fast and safe. Besides their short turnaround time, no specific equipment or skilled technicians’ requirements, they can serve as a rapid diagnostic test of RT-PCR-negative symptomatic patients and screening of SARS CoV-2 carriers. It cannot take the place of PCR, but the huge lab diagnosis pressure can be greatly relieved and more research is needed to detect its reliability in limited-resource settings.
Keywords: COVID-19, Rapid Test, IgM/IgG, Sensitivity, Specificity, Limited-resource.
Peningkatan profesionalisme guru SDN 2 Palembang melalui pengembangan media pembelajaran berbasis multimedia
Authors: Salamah Irma , Kusumanto Raden , Lindawati Lindawati 
Published: July 2020

[Bahasa]: Perkembangan teknologi informasi menjadi salah satu peluang yang dapat dimanfaatkan guru dalam meningkatkan kualitas pembelajaran di kelas. Banyaknya perangkat lunak (software) yang tersedia dapat dimanfaatkan guru untuk mengembangkan media pembelajaran yang lebih interaktif dan menarik minat belajar siswa. Program pengabdian kepada masyarakat (PKM) ini bertujuan untuk meningkatkan profesionalisme guru-guru Sekolah Dasar Negeri (SDN) 2 Palembang dalam membuat media pembelajaran berbasis komputer dan multimedia sehingga lebih meningkatkan efisiensi waktu penyampaian materi pembelajaran dan proses belajar mengajar menjadi lebih menarik. Metode yang digunakan dalam kegiatan ini adalah metode ceramah, praktek/pelatihan, dan tanya jawab. Hasil PKM ini menunjukkan guru-guru SDN 2 Palembang dapat mengikuti pelatihan ini dengan baik. Melalui kegiatan ini guru dapat membuat presentasi berbasis media dan mampu menambahkan animasi pada media tersebut sehingga menjadi lebih menarik. Dengan demikian kegiatan pelatihan pengembangan media pembelajaran berbasis multimedia ini efektif dalam meningkatkan profesionalisme guru sekolah dasar.
Kata Kunci: media pembelajaran, multimedia, profesionalisme guru
[English]: The development of information technology is one of the opportunities that can be utilized by teachers to improve the quality of learning in the classroom. A large amount of available software can be used by teachers to develop interactive learning media and attract students' interest in learning. This community service program aims to improve the teachers’ professionalism in Palembang Elementary School (SDN) 2 in making computer-based and multimedia-based learning media so as to increase the efficiency of time delivery of learning materials and teaching and learning processes become more interesting. The method used in this program was the lecture, practice/training, and question and answer. The results showed that the teachers of SDN 2 Palembang take part in this training well. Through this activity, the teachers are able to make a media-based presentation and add animation to the media so that it becomes more interesting. Thus, the training of developing multimedia-based learning media is effective in increasing the professionalism of elementary school teachers.
Keywords: instructional media, multimedia, teacher professionalism