bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between lncRNA‐H19 polymorphisms and hepatoblastoma risk in an ethic Chinese population
Authors: Tan Tianbao , Li Jiahao , Wen Yang , Zou Yan , Yang Jiliang , Pan Jing , Hu Chao , Yao Yuxiao , Zhang Jiao , Xin Yijuan , Li Suhong , Xia Huimin , He Jing , Yang Tianyou 
Published: November 2020

AbstractH19 polymorphisms are associated with increased susceptibility to several cancers; however, their role in hepatoblastoma remains unclear. In this study, we investigated the association between three H19 polymorphisms (rs2839698 G>A, rs3024270 C>G, rs217727 G>A) and hepatoblastoma susceptibility in 213 hepatoblastoma patients. The rs2839698 and rs3024270 polymorphisms were associated with significantly increased hepatoblastoma risk, with the GG genotype associated with a higher risk of hepatoblastoma than the CC genotype at the rs3024270 locus. The rs217727 polymorphism was associated with significantly decreased hepatoblastoma risk, with the AG genotype associated with a lower risk of hepatoblastoma than the GG genotype. These findings were confirmed by combined analysis, and stratification analysis revealed that age, gender and clinical stage were associated with increased hepatoblastoma susceptibility. The GGG and AGG haplotypes were significantly associated with increased hepatoblastoma risk compared with the GCA reference (rs2839698, rs3024270, rs217727). The rs2839698 and rs3024270 polymorphisms correlated with decreased MRPL23‐AS1 expression, whereas the rs217727 polymorphism was associated with increased MRPL23‐AS1 expression. Overall, the H19 rs2839698, rs3024270 and rs217727 polymorphisms were associated with hepatoblastoma susceptibility in a Chinese Han population.
Beta‐defensin 1 gene polymorphisms in the pathologies of the oral cavity—Data from meta‐analysis: Association only with rs1047031 not with rs1800972, rs1799946, and rs11362
Authors: Ślebioda Zuzanna , Woźniak Tomasz , Dorocka‐Bobkowska Barbara , Woźniewicz Małgorzata , Kowalska Anna 
Published: November 2020

AbstractObjectivesThe purpose of this meta‐analysis was to reveal a potential association of the four functional polymorphisms in human Beta‐defensin 1 (DEFB1) gene: rs1047031(c*5G > A) at 3’UTR and rs11362 (−20 G > A), rs1800972(−44 C > G), and rs1799946 (−52 G > A) at 5’UTR with the risk of common oral cavity pathologies that included periodontitis, caries, lichen planus, and recurrent aphthous stomatitis.MethodsThe relevant studies were obtained by the two researchers from PubMed, Scopus, and Web of Science up to April 29, 2020. The manual search of the reference lists was also performed. Studies on DEFB1 gene polymorphisms and oral cavity disorders, using the case‐control genetic association analysis approach, and published as full texts in English were included. To assess the association strength, odds ratios (ORs) with their 95% confidence intervals (CIs) were extracted.ResultsThirteen publications met the inclusion criteria and were incorporated in this meta‐analysis. Statistically significant values of the association tests were found only for the rs1047031 polymorphism. Allele distribution in the rs1047031 polymorphism was significantly associated with susceptibility to oral cavity pathologies (adjusted P value = 0.003). The rare variant allele carriers had a significantly higher risk for oral disasters under recessive (CC vs CT + TT), and CC vs CT models. No significant correlations between rs11362, rs1800972, and rs1799946 and the risk of oral pathologies were revealed.ConclusionsSignificant association between rs1047031 polymorphism and risk of oral pathologies has been found, and therefore, we suggest to include this polymorphism in future research concerning the genetic background of the oral cavity diseases.
Coming to stay or to go? Stay intention and involved uncertainty of international students
Authors: Koenings Fabian , Haussen Tina , Toepfer Stefan , Uebelmesser Silke 
Published: November 2020

AbstractCountries compete for young talents to alleviate skilled‐labor shortage. International students, who stay after graduation, allow host countries to overcome this challenge. This study investigates the factors associated with international students' intention to stay or to go after graduation from a host country's perspective. In contrast to the literature, this analysis employs survey data collected from first‐semester students. This assures that the analysis is not distorted by attrition. Furthermore, it allows policymakers to address those students who would be no longer around later in the absence of any policy measure. At the same time, it requires to deal with uncertainty as the actual migration decision will be later. This study introduces a set of uncertainty models to the migration context. The results show that, next to career opportunities and a stay in the host country before the studies, being enrolled in a Bachelor program instead of a Master program is significantly associated with the intention to stay. The findings are largely robust to different approaches accounting for the uncertainty involved. Further, Master students are found to be significantly more uncertain than Bachelor students.
Surfacing consumer psychosensory perceptions of a nonendemic food: The case of coffee in a tea culture
Authors: Caskey D'Arcy , Chen Judy F. , Warden Clyde A. 
Published: November 2020

AbstractIntroducing a culturally unfamiliar food to a new market requires understanding local meaning. Local psychological associations with nonendemic food often remain masked from common research methods such as surveys and home interviews. We apply a localized adaptation of the Zaltman Metaphor Elicitation Technique to explore consumer psychosensory perceptions of nonendemic foods—the contemporary phenomenon of coffee's acceptance in Taiwan's tea‐dominated market. A purposive sample of 10 trial and 20 full study participants, avid coffee drinkers, ranged in age from 19 to 52. Participants were supplied with single‐use film‐based cameras that they carried about in everyday life to snap photos later used in structured interviews. Over 120 concepts were generated from a total count of 95,472 transcribed words. This resulted in six top‐level categories: emotions/feelings, flavor/taste/color, cultural integration, nature, eat/drink, and coffee type organized in hierarchies of meaning. Participants consistently associated coffee with the desire for relaxation, enjoyment, and nature.Practical ApplicationsThe revealed psychometric themes unearthed in this study suggest practical applications including informing market positioning segmentation strategies. In Taiwan's tea culture, findings show coffee plays a strong metaphorical role in consumers' psychology of escape and retreat from hectic daily life. Marketers of coffee should align with this theme rather than the standard Western messaging of energy and motivation boosting. This local metaphor provides coffee with a better opportunity for market adoption. Building on locally meaningful representations is key to market penetration and a strategy of glocalization that is fundamental to marketing of nonendemic food products. Successful diffusion of a nonendemic food product begins from a core group of dedicated loyal users, like the participants in the current study. By understanding the values these consumers associate with the nonendemic product, marketing managers can identify and select key features and meanings to emphasize in the product's design and marketing communications.
Risk of malaria in young children after periconceptional iron supplementation
Authors: Gies Sabine , Roberts Stephen A. , Diallo Salou , Lompo Olga M. , Tinto Halidou , Brabin Bernard J. 
Published: November 2020

AbstractThis study in Burkina Faso investigated whether offspring of young mothers who had received weekly periconceptional iron supplementation in a randomised controlled trial were at increased risk of malaria. A child safety survey was undertaken in the peak month of malaria transmission towards the end of the trial to assess child iron biomarkers, nutritional status, anaemia and malaria outcomes. Antenatal iron biomarkers, preterm birth, fetal growth restriction and placental pathology for malaria and chorioamnionitis were assessed. Data were available for 180 babies surviving to the time of the survey when their median age was 9 months. Prevalence of maternal iron deficiency in the last trimester based on low body iron stores was 16%. Prevalence of active placental malaria infection was 24.8%, past infection 59% and chorioamnionitis 55.6%. Babies of iron supplemented women had lower median gestational age. Four out of five children ≥ 6 months were iron deficient, and 98% were anaemic. At 4 months malaria prevalence was 45%. Child iron biomarkers, anaemia and malaria outcomes did not differ by trial arm. Factors associated with childhood parasitaemia were third trimester C‐reactive protein level (OR 2.1; 95% CI 1.1–3.9), active placental malaria (OR 5.8; 1.0–32.5,P= 0.042) and child body iron stores (OR 1.13; 1.04–1.23,P= 0.002). Chorioamnionitis was associated with reduced risk of child parasitaemia (OR 0.4; 0.1–1.0,P= 0.038). Periconceptional iron supplementation of young women did not alter body iron stores of their children. Higher child body iron stores and placental malaria increased risk of childhood parasitaemia.
ClpP1P2 peptidase activity promotes biofilm formation in Pseudomonas aeruginosa
Authors: Mawla Gina D. , Hall Branwen M. , Cárcamo‐Oyarce Gerardo , Grant Robert A. , Zhang Jia Jia , Kardon Julia R. , Ribbeck Katharina , Sauer Robert T. , Baker Tania A. 
Published: November 2020

AbstractCaseinolytic proteases (Clp) are central to bacterial proteolysis and control cellular physiology and stress responses. They are composed of a double‐ring compartmentalized peptidase (ClpP) and a AAA+ unfoldase (ClpX or ClpA/ClpC). Unlike many bacteria, the opportunistic pathogen Pseudomonas aeruginosa contains two ClpP homologs: ClpP1 and ClpP2. The specific functions of these homologs, however, are largely elusive. Here, we report that the active form of PaClpP2 is a part of a heteromeric PaClpP17P27 tetradecamer that is required for proper biofilm development. PaClpP114 and PaClpP17P27 complexes exhibit distinct peptide cleavage specificities and interact differentially with P. aeruginosa ClpX and ClpA. Crystal structures reveal that PaClpP2 has non‐canonical features in its N‐ and C‐terminal regions that explain its poor interaction with unfoldases. However, experiments in vivo indicate that the PaClpP2 peptidase active site uniquely contributes to biofilm development. These data strongly suggest that the specificity of different classes of ClpP peptidase subunits contributes to the biological outcome of proteolysis. This specialized role of PaClpP2 highlights it as an attractive target for developing antimicrobial agents that interfere specifically with late‐stage P. aeruginosa development.
Badnaviruses and banana genomes: a long association sheds light on Musa phylogeny and origin
Authors: Chabannes Matthieu , Gabriel Marc , Aksa Abderrahmane , Galzi Serge , Dufayard Jean‐François , Iskra‐Caruana Marie‐Line , Muller Emmanuelle 
Published: November 2020

AbstractBadnaviruses are double‐stranded DNA pararetroviruses of the family Caulimoviridae. Badnaviral sequences found in banana are distributed over three main clades of the genus Badnavirus and exhibit wide genetic diversity. Interestingly, the nuclear genome of many plants, including banana, is invaded by numerous badnaviral sequences although badnaviruses do not require an integration step to replicate, unlike animal retroviruses. Here, we confirm that banana streak viruses (BSVs) are restricted to clades 1 and 3. We also show that only BSVs from clade 3 encompassing East African viral species are not integrated into Musa genomes, unlike BSVs from clade 1. Finally, we demonstrate that sequences from clade 2 are definitively integrated into Musa genomes with no evidence of episomal counterparts; all are phylogenetically distant from BSVs known to date. Using different molecular approaches, we dissected the coevolution between badnaviral sequences of clade 2 and banana by comparing badnavirus integration patterns across a banana sampling representing major Musa speciation events. Our data suggest that primary viral integrations occurred millions of years ago in banana genomes under different possible scenarios. Endogenous badnaviral sequences can be used as powerful markers to better characterize the Musa phylogeny, narrowing down the likely geographical origin of the Musa ancestor.
The cellular mechanobiology of aging: from biology to mechanics
Authors: Bajpai Apratim , Li Rui , Chen Weiqiang 
Published: November 2020

AbstractAging is a chronic, complicated process that leads to degenerative physical and biological changes in living organisms. Aging is associated with permanent, gradual physiological cellular decay that affects all aspects of cellular mechanobiological features, including cellular cytoskeleton structures, mechanosensitive signaling pathways, and forces in the cell, as well as the cell's ability to sense and adapt to extracellular biomechanical signals in the tissue environment through mechanotransduction. These mechanobiological changes in cells are directly or indirectly responsible for dysfunctions and diseases in various organ systems, including the cardiovascular, musculoskeletal, skin, and immune systems. This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establishes mechanistic frameworks to understand the mechanobiological effects of aging on disease progression and to develop new strategies for halting and reversing the aging process. Our review also highlights the recent development of novel bioengineering approaches for studying the key mechanobiological mechanisms in aging.
Determination of growth and development periods in orthodontics with artificial neural network
Authors: Kök Hatice , Izgi Mehmet Said , Acilar Ayşe Merve 
Published: November 2020

AbstractBackgroundWe aimed to determine the growth‐development periods and gender from the cervical vertebrae using the artificial neural network (ANN).Setting and Sample PopulationThe cephalometric and hand‐wrist radiographs obtained from 419 patients aged between 8 and 17 years were included in our study.Materials and MethodsOur retrospective study consisted of 419 patients’ cephalometric and hand‐wrist radiographs. The cephalometric radiographs were divided into six cervical vertebrae stages (CVS). Correlations were evaluated between hand‐wrist maturation level, CVS, and ages. Twenty‐seven vertebral reference points are marked on the cephalometric radiograph, and 32 linear measurements were taken. With the combination of these measurements, 24 different data sets were formed to train ANN. Thus, 24 different ANN models for the determination of the growth‐development periods were obtained. According to the results, seven ANN models that have a high success level and clinically applicable were selected. Also, an ANN model was done by all measurements and age for the determination of gender from cervical vertebrae.ResultsSignificantly positive correlations between hand‐wrist maturation level, CVS and ages were detected. The ANN‐7 model (32 linear measurements and age) accuracy value was found 0.9427. The highest model accuracy, 0.8687, with the least linear measurements, was obtained by drawing 13 linear measurements, using vertical measurements and indents. Gender was determined using ANN (0.8950) on cervical vertebrae data.ConclusionThe growth‐development periods and gender were determined from the cervical vertebrae by using ANN. The success of the ANN algorithm has been satisfactory. Further studies are needed for a fully automatic decision support system.
Allergic bronchopulmonary aspergillosis in children
Authors: Manti Sara , Parisi G Fabio , Papale Maria , Licari Amelia , Chiappini Elena , Mulè Enza , Rotolo Novella , Leonardi Salvatore 
Published: November 2020

AbstractAllergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease caused by Aspergillus induced hypersensitivity that occurs in immunocompetent but susceptible patients with asthma and/or cystic fibrosis (CF). In children, ABPA remains mostly undiagnosed resulting in one of the most common causes of poorly controlled asthma and highly significant morbidity in children with CF. Currently, no specific diagnostic criteria of ABPA for children are available. Corticosteroids and itraconazole are the mainstays of therapy although there is a lack of randomized clinical trials regarding their usefulness for ABPA in children. Several monoclonal antibodies, such as omalizumab and mepolizumab, may be potential therapies for refractory ABPA in pediatric patients; however, further data are required to clarify the optimal dose and duration of therapy as a routine treatment approach.
Immunological basis of virus‐host interaction in COVID‐19
Authors: La Torre Francesco , Leonardi Lucia , Giardino Giuliana , Volpi Stefano , Federici Silvia , Soresina Annarosa , Cancrini Caterina , Lougaris Vassilios , Castagnoli Riccardo , Corrente Stefania , Cardinale Fabio ,   the Immunology Commission of the Italian Society of Pediatric Allergy, Immunology (SIAIP)
Published: November 2020

AbstractCOVID‐19 is a complex new viral disease, in which a strict balance between anti‐viral immune response and the ensuing organ inflammation has a critical role in determining the clinical course. In adults, compelling evidence exists indicating that an uncontrolled inflammatory response ("cytokine storm") is pivotal in determining disease progression and mortality. Children may rarely present with severe disease. Modulating factors related to the host's genetic factors, age‐related susceptibility, and the capability to mount appropriate immune responses might play a role in control virus load at an early stage and regulating the inflammatory reaction. Elucidating these mechanisms seems crucial in developing target therapies according to patient's age, immunologic status, and disease evolution in COVID‐19.
Updates on new monogenic inborn errors of immunity
Authors: Castagnoli Riccardo , Notarangelo Luigi Daniele 
Published: November 2020

AbstractInborn errors of immunity (IEI), also referred to as primary immunodeficiencies (PID), are disorders that, for the most part, result from mutations in genes involved in immune host defense and immune regulation. Thanks to the increased availability of high‐throughput DNA sequencing and the improvement in genomic data interpretation, the number of newly identified genes associated with IEI has exponentially increased over the last decade. We reviewed four recently described monogenic IEI and discussed the clinical and immunologic features of these new conditions.
Random forest analysis identifies change in serum creatinine and listing status as the most predictive variables of an outcome for young children on liver transplant waitlist
Authors: Kulkarni Sakil , Chi Lisa , Goss Charles , Lian Qinghua , Nadler Michelle , Stoll Janis , Doyle Maria , Turmelle Yumirle , Khan Adeel 
Published: November 2020

AbstractYoung children listed for liver transplant have high waitlist mortality (WL), which is not fully predicted by the PELD score. SRTR database was queried for children < 2 years listed for initial LT during 2002‐17 (n = 4973). Subjects were divided into three outcome groups: bad (death or removal for too sick to transplant), good (spontaneous improvement), and transplant. Demographic, clinical, listing history, and laboratory variables at the time of listing (baseline variables), and changes in variables between listing and prior to outcome (trajectory variables) were analyzed using random forest (RF) analysis. 81.5% candidates underwent LT, and 12.3% had bad outcome. RF model including both baseline and trajectory variables improved prediction compared to model using baseline variables alone. RF analyses identified change in serum creatinine and listing status as the most predictive variables. 80% of subjects listed with a PELD score at time of listing and outcome underwent LT, while ~70% of subjects in both bad and good outcome groups were listed with either Status 1 (A or B) prior to an outcome, regardless of initial listing status. Increase in creatinine on LT waitlist was predictive of bad outcome. Longer time spent on WL was predictive of good outcome. Subjects with biliary atresia, liver tumors, and metabolic disease had LT rate >85%, while >20% of subjects with acute liver failure had a bad outcome. Change in creatinine, listing status, need for RRT, time spent on LT waitlist, and diagnoses were the most predictive variables.
Public health nurses’ experiences learning and delivering a group cognitive behavioral therapy intervention for postpartum depression
Authors: Layton Haley , Bendo Daniella , Amani Bahar , Bieling Peter J. , Van Lieshout Ryan J. 
Published: November 2020

AbstractObjectivesPublic Health Nurses (PHNs) often provide support to women with postpartum depression (PPD) in the absence of specialized training. The objective of this study was to explore the experiences of six PHNs who were trained to deliver a group cognitive behavioral therapy (CBT) intervention for PPD in the public health setting, and to describe how learning and delivering this intervention affected their professional roles and personal lives.DesignThis qualitative study employed a phenomenological approach.SampleSix PHNs who completed the CBT training program and delivered at least one CBT group in their community.MeasurementsIndividual in‐depth interviews were conducted and transcribed verbatim. Transcripts were analyzed according to thematic derivation procedures.ResultsThe themes that emerged from the interviews with the PHNs included: (a) components of the CBT training program that nurses most valued, (b) benefits of training for their professional role as a PHN, (c) implications for practice, and (d) using CBT skills in their personal lives.ConclusionsThe provision of CBT training to PHNs may not only positively impact their work with clients with mental illness, but may also have the potential to provide broader clinical and professional benefits for these skilled professionals and their other clients.
Polls and Elections: The Economy and Events Still Matter (At Least a Little): Partisans' Presidential Approval in the Trump Era
Authors: Newman Brian , Otto Amber 
Published: November 2020

AbstractDonald Trump's historically stable and polarized approval ratings raise concerns that partisans' evaluations of Trump are detached from real‐world conditions like the state of the economy and Trump's actions. We show that Republicans' (but not Democrats') approval and strength of (dis)approval tracked with stock market performance and perceptions of the economy. In addition, both Democrats and Republicans rewarded and punished Trump after major events. In some instances, Republicans and Democrats responded to events in similar ways, but in others, events further polarized partisans' views of Trump. At least to some degree, Republican approval responds to the economy and major events.