bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 12-Item Pruritus Severity Scale – Determining the Severity Bands
Authors: Stępień Katarzyna , Reich Adam 
Published: December 2020

Introduction: Assessment of pruritus still remains a challenge due to its subjective character. Various itch questionnaires are widely used to evaluate the severity of pruritus. The aim of the current study was to define the cut off values for the 12-Item Pruritus Severity Scale (12-PSS).Methods: A total of 240 patients (86 males and 154 females) in the age between 19 and 87 years (mean 52.9 ± 20.7 years) suffering from pruritic dermatological conditions were asked to assess their maximal pruritus with the 12-PSS, the Verbal Rating Scale (VRS) and the Numerical Rating Scale (NRS). All subjects also completed the Dermatology Life Quality Index (DLQI). VRS, NRS, and DLQI scorings were used as anchor measures to define cut-offs of 12-PSS.Results: According to VRS, 43 (17.9%) patients suffered from mild, 96 (40%) from moderate, 65 (27.1%) from severe and 36 (15%) from very severe pruritus. Mean 12-PSS scoring for each VRS category was 7.6 ± 3.9, 10.4 ± 3.9, 13.0 ± 3.8, and 13.9 ± 3.8 points, respectively (p &lt; 0.001). Each VRS category significantly differed from the others regarding the mean 12-PSS scoring, except the mean scoring of severe and very severe pruritus (p = 0.72). Thus, three pruritus severity categories of 12-PSS were defined with following score ranges: mild pruritus−3–6 points of 12-PSS, moderate pruritus−7–11 points of 12-PSS and severe pruritus−12–22 points of 12-PSS based on calculation of weighted κ coefficient against VRS, NRS, and DLQI as anchor measures.Conclusions: The 12-PSS is able to differentiate between patients suffering from mild, moderate, and severe pruritus.
The Impact of the COVID-19 Pandemic on People With Epilepsy. An Italian Survey and a Global Perspective
Authors: Mostacci Barbara , Licchetta Laura , Cacciavillani Carlotta , Di Vito Lidia , Ferri Lorenzo , Menghi Veronica , Stipa Carlotta , Avoni Patrizia , Provini Federica , Muccioli Lorenzo , Vignatelli Luca , Mazzoni Stefania , Tinuper Paolo , Bisulli Francesca 
Published: December 2020

Objectives: We explored the impact of the coronavirus disease-19 (COVID-19) emergency on the health of people with epilepsy (PwE). We also investigated their attitude toward telemedicine.Methods: The PubMed database up to September 10, 2020 was searched for questionnaire-based studies conducted in PwE during the COVID-19 emergency, and the literature retrieved was reviewed. In addition, all patients who had a telephone consultation with our center between May 7 and July 31, 2020 were invited to fill in a 57-item online questionnaire focusing on epilepsy and comorbidities, any changes in lifestyle or clinical conditions and any emergency-related problems arising during the COVID-19 emergency, and their views on telemedicine. Associations between variables were detected through X2 test and Fisher's exact test. Univariate and multivariate logistic regression models were used to evaluate the effects of different factors on clinical conditions.Results: Twelve studies met the literature search criteria. They showed that the rate of seizure worsening during the emergency ranged from 4 to 35% and was mainly correlated with epilepsy severity, sleep disturbances and COVID-19-related issues. Our questionnaire was filled in by 222 PwE or caregivers. One hundred (76.6%) reported unchanged clinical conditions, 25 (11.3%) an improvement, and 27 (12%) a deterioration. Reported clinical worsening was associated with a psychiatric condition and/or medication (OR = 12.59, p &lt; 0.001), sleep disorders (OR = 8.41, p = 0.001), limited access to healthcare (OR = 4.71, p = 0.016), and experiencing seizures during the emergency (OR = 4.51, p = 0.007). Telemedicine was considered acceptable by 116 subjects (52.3%).Conclusions: Most PwE did not experience a significant change in their clinical conditions during the COVID-19 emergency. However, severity of epilepsy, concomitant disability, comorbid psychiatric conditions, sleep disorders and limited access to healthcare may affect their health.
Acacetin Protects Against High Glucose-Induced Endothelial Cells Injury by Preserving Mitochondrial Function via Activating Sirt1/Sirt3/AMPK Signals
Authors: Han Wei-Min , Chen Xu-Chang , Li Gui-Rong , Wang Yan 
Published: December 2020

The strategy of decreasing atherosclerotic cardiovascular disorder is imperative for reducing premature death and improving quality of life in patients with diabetes mellitus. The aim of this study was to investigate whether the natural flavone acacetin could protect against endothelial injury induced by high glucose and attenuate diabetes-accelerated atherosclerosis in streptozotocin-(STZ) induced diabetic ApoE−/− mice model. It was found that in human umbilical vein endothelial cells (HUVECs) cultured with normal 5.5 mM or high 33 mM glucose, acacetin (0.3–3 μM) exerted strong cytoprotective effects by reversing high glucose-induced viability reduction and reducing apoptosis and excess production of intracellular reactive oxygen species (ROS) and malondialdehyde in a concentration-dependent manner. Acacetin countered high glucose-induced depolarization of mitochondrial membrane potential and reduction of ATP product and mitoBcl-2/mitoBax ratio. Silencing Sirt3 abolished the beneficial effects of acacetin. Further analysis revealed that these effects of acacetin rely on Sirt1 activation by increasing NAD+ followed by increasing Sirt3, pAMPK and PGC-1α. In STZ-diabetic mice, acacetin significantly upregulated the decreased signaling molecules (i.e. SOD, Bcl-2, PGC-1α, pAMPK, Sirt3 and Sirt1) in aorta tissue and attenuated atherosclerosis. These results indicate that vascular endothelial protection of acacetin by activating Sirt1/Sirt3/AMPK signals is likely involved in alleviating diabetes-accelerated atherosclerosis by preserving mitochondrial function, which suggests that acacetin may be a drug candidate for treating cardiovascular disorder in patients with diabetes.
The Mediating Effect of Physical Function Decline on the Association Between Social Activity and Cognitive Function in Middle and Older Korean Adults: Analyzing Ten Years of Data Through Multivariate Latent Growth Modeling
Authors: Bae Sung Man 
Published: December 2020

PurposeThis study aimed to examine the long-term association between social activity, physical function decline and cognitive function, as well as verify the long-term mediating effect of physical function decline on the relationship between social activity and cognitive function.MethodsData from the Korean Longitudinal Study of Aging (KLoSA) that was collected over 10 years was analyzed. The sample included 10,240 adults aged 45–93 years (Mean age = 61.66 [SD = 11.061]). Multivariate latent growth modeling (LGM) was applied to verify the long-term effect of social activity and physical function on cognitive function.ResultsThe results revealed that social activity had a positive impact on cognitive function and negative impact on physical function decline after controlling for age and education level. Additionally, physical function decline negatively influenced cognitive function. Finally, social activity indirectly affected cognitive function through physical function decline.ConclusionThe contribution of this study was to test the long-term effect social activity on physical and cognitive function.
Monitoring Changes in Depression Severity Using Wearable and Mobile Sensors
Authors: Pedrelli Paola , Fedor Szymon , Ghandeharioun Asma , Howe Esther , Ionescu Dawn F. , Bhathena Darian , Fisher Lauren B. , Cusin Cristina , Nyer Maren , Yeung Albert , Sangermano Lisa , Mischoulon David , Alpert Johnathan E. , Picard Rosalind W. 
Published: December 2020

Background: While preliminary evidence suggests that sensors may be employed to detect presence of low mood it is still unclear whether they can be leveraged for measuring depression symptom severity. This study evaluates the feasibility and performance of assessing depressive symptom severity by using behavioral and physiological features obtained from wristband and smartphone sensors.Method: Participants were thirty-one individuals with Major Depressive Disorder (MDD). The protocol included 8 weeks of behavioral and physiological monitoring through smartphone and wristband sensors and six in-person clinical interviews during which depression was assessed with the 17-item Hamilton Depression Rating Scale (HDRS-17).Results: Participants wore the right and left wrist sensors 92 and 94% of the time respectively. Three machine-learning models estimating depressive symptom severity were developed–one combining features from smartphone and wearable sensors, one including only features from the smartphones, and one including features from wrist sensors–and evaluated in two different scenarios. Correlations between the models' estimate of HDRS scores and clinician-rated HDRS ranged from moderate to high (0.46 [CI: 0.42, 0.74] to 0.7 [CI: 0.66, 0.74]) and had moderate accuracy with Mean Absolute Error ranging between 3.88 ± 0.18 and 4.74 ± 1.24. The time-split scenario of the model including only features from the smartphones performed the best. The ten most predictive features in the model combining physiological and mobile features were related to mobile phone engagement, activity level, skin conductance, and heart rate variability.Conclusion: Monitoring of MDD patients through smartphones and wrist sensors following a clinician-rated HDRS assessment is feasible and may provide an estimate of changes in depressive symptom severity. Future studies should further examine the best features to estimate depressive symptoms and strategies to further enhance accuracy.
Variability of Gravity Wave Effects on the Zonal Mean Circulation and Migrating Terdiurnal Tide as Studied With the Middle and Upper Atmosphere Model (MUAM2019) Using a Nonlinear Gravity Wave Scheme
Authors: Lilienthal Friederike , Yiğit Erdal , Samtleben Nadja , Jacobi Christoph 
Published: December 2020

Implementing a nonlinear gravity wave (GW) parameterization into a mechanistic middle and upper atmosphere model, which extends to the lower thermosphere (160 km), we study the response of the atmosphere in terms of the circulation patterns, temperature distribution, and migrating terdiurnal solar tide activity to the upward propagating small-scale internal GWs originating in the lower atmosphere. We perform three test simulations for the Northern Hemisphere winter conditions in order to assess the effects of variations in the initial GW spectrum on the climatology and tidal patterns of the mesosphere and lower thermosphere. We find that the overall strength of the source level momentum flux has a relatively small impact on the zonal mean climatology. The tails of the GW source level spectrum, however, are crucial for the lower thermosphere climatology. With respect to the terdiurnal tide, we find a strong dependence of tidal amplitude on the induced GW drag, generally being larger when GW drag is increased.
Resection of Large Urological Tumors With or Without Inferior Vena Cava Extension in Jehova's Witnesses
Authors: Ciancio Gaetano , Gonzalez Javier 
Published: December 2020

Background: Renal and adrenal tumors with/without tumor thrombus in the inferior vena cava (IVC) pose a challenge to the surgeon due to the potential for massive hemorrhage and tumor thromboemboli. The situation would be more critical for Jehovah's Witness (JW) patients which refuse blood transfusion. A transplant-based (TB) approach to these tumors in JWs would result a safe surgical method, providing limited blood loss and perioperative complications. We report our experience using a TB surgical approach in JW harboring large adrenal/renal tumors with/without tumor thrombus trying to determine its usefulness in this setting.Patients and Methods: From 2003 to 2011, 7 patients underwent resection of renal/adrenal tumors with/without tumor thrombus in the IVC by means of a TB approach. Thrombus level was renal (n = 2), retrohepatic (n = 1), and suprahepatic (n = 1). The remaining 3 patients did not present thrombus. No pre-operative optimization or cell-saver were used. Estimated blood loss, perioperative complications (Clavien-Dindo and cause), hemoglobin/hematocrit loss, and length of stay were considered main outcomes.Results: The intervention was successfully completed without transfusion in all cases. Operative time and blood loss were 2.5 h (range: 1.83–5.75) and 150 cc (range: 100–750), respectively. No major post-operative complications were registered. However, minor complications were detected in 57% of the patients included. Median hemoglobin loss was 1.13 mg/dL, which translated a median hematocrit loss of 2.3%. Patients were discharged in a median of 7 days (range 5–20).Conclusions: A TB-surgical approach provides enhanced retroperitoneal exposure and optimal vascular control, thus limiting operative blood loss or major complication development, thus resulting useful in JWs.
UPAYA PENCEGAHAN DAN SOLUSI TERHADAP TIMBULNYA PENCEMARAN LINGKUNGAN HIDUP DARI BUANGAN LIMBAH INDUSTRI
Authors: Ratna Anjarsari Siska , Rochmani Rochmani 
Published: December 2020

Pencemaran lingkungan hidup akibat buangan limbah industri menjadi perhatian yang tidak pernah surut. Semakin banyak kasus pencemaran lingkungan hidup akibat buangan limbah industri, hal tersebut sangat mengganggu dan meresahkan kehidupan masyarakat serta mengancam kelestarian fungsi lingkungan hidup. Metode penelitian yang digunakan dalam penelitian adalah yuridis normatif dengan melakukan penelusuran terhadap peraturan-peraturan dan literatur- literatur yang berkaitan dengan permasalahan yang diteliti. Tujuan penelitian menjelaskan pencegahan dan solusi terhadap timbulnya pencemaran. Hasil penelitian menunjukkan, upaya pencegahan dan solusi terhadap timbulnya pencemaran lingkungan dengan melakukan perencanana proses produksi yang baik, akurat dan cermat mengurangi penggunaan bahan-bahan kimia pembantu yang rendah beban pencemaran, pengontrolan pemakaian air yang hemat dan efisien, memanfaatkan dan menggunakan kembali (reuse) bahan-bahan kimia yang terdapat dalam limbah cair untuk keperluan produksi serta berupaya memantau limbah hasil pasca proses kegiatan minimasi limbah.

Kata kunci : limbah, lingkungan hidup, pencemaran, pencegahan, solusi.
Derecho de los trabajadores a la desconexión digital: mail on holiday
Authors: Pérez Amorós Francisco 
Published: December 2020

El derecho a la desconexión digital el los trabajadores fuera de jornada, reconocido en 2018, faculta al trabajador a no responder a las comunicaciones de trabajo del empresario que reciba fuera del horario laboral. El reconocimiento ha suscitado comentarios positivos, pero también algunas críticas por una ambigüedad. La desconexión legal –en el contexto digital- pretende evitar prolongaciones indebidas de la jornada que puedan menoscabar el descanso, la conciliación familiar, la salud, y la intimidad (derecho fundamental).
Logos und Glaube im “secular age.”
Authors: Jagiełło Jarosław 
Published: December 2020

The chief motivation for undertaking this research comes from my encounter with Charles Taylor’s excellent work, “A Secular Age,” in which he not only analyzes the various historical manifestations of secularization in Western civilization, but also—and above all—tries to identify the newly emerging conditions in which forms of religious belief may develop on the threshold of the new millennium, in the context of what he himself describes as a secular age.
My paper chiefly focuses on the fact that the routes leading to, and attempts to bring about, a revival of Christian spirituality in the modern world, which Taylor describes in his book, were already a concern for many philosophers working at the start of the 20th century. One amongst these, the Austrian thinker Ferdinand Ebner, occupies a special position.
Known to the philosophical world as one of the originators of dialogical thinking, Ebner uncovers the real key to the revitalization and consolidation of Christian spirituality in the form of the reality of the spoken word. First and foremost, his philosophy of the word constitutes a spectacular example of the intensive search for meaning in life: something not always easy for human beings in a secular age to discover and define for themselves. In this paper I also aim to present the basis for Ebner’s assertion of an inseparable link between the word and religious faith, and to show how this relationship founds a possibility for the renewal of Christian spirituality in the modern world.
Optimasi Decision Tree menggunakan Particle Swarm Optimization untuk klasifikasi sel Pap Smear
Authors: Arifin Toni 
Published: December 2020

Penelitian ini menyajikan klasifikasi sel Pap Smear. Data yang digunakan adalah dataset Herlev yang berjumlah 917 data. Penelitian ini bertujuan untuk mengetahui apakah penggunaan algoritma optimasi particle swarm optimization dapat meningkatkan kinerja dari algoritma Decision tree dalam mengklasifikasikan data Sel Pap Smear. Tahapan dari penelitian ini adalah preprocessing, feature optimization, knowledge rules, evaluation dan performance report. Hasil dari penelitian ini menunjukkan bahwa algoritma Decision tree menghasilkan akurasi sebesar 91.39 % dengan AUC 0.858, sedangkan penerapan algoritma particle swarm optimization pada Decision tree menghasilkan akurasi yang lebih baik yaitu sebesar 96.76 % dengan AUC 0.926.
Analisis Manajemen Risiko Teknologi Informasi Policy Service PT. Asuransi Sinar Mas Menggunakan Framework COBIT 5
Authors: Wibawa Marco Putra , Manuputty Augie David 
Published: December 2020

Penelitian ini dilakukan bertujuan untuk mengetahui kondisi penerapan manajemen risiko dan mengidentifikasi ancaman risiko terhadap proses bisnis di PT. Asuransi Sinar Mas. Hal ini dikarenakan untuk analisis manajemen risiko sudah menjadi hal yan patut diperhitungkan oleh suatu perusahaan dalam meningkatkan keuntungan dan asset perusahaan yang akan selalu menjadi bagian penting dalam suatu perusahaan. Untuk mengetahui seberapa pengaruh manajemen risiko bagi Divisi Policy Service di PT. Asuransi Sinar Mas, maka perlu dilakukan pengujian terhadap kondisi penerapan manajemen risiko yang sudah berjalan pada perusahaan tersebut. Penelitian ini penulis menggunakan metode Mix Method, untuk pengumpulan data penulis menggunakan metode kuantitatif yang disebarkan kepada 18 responden. Kemudian untuk melengkapi data Kuantitatif tersebut penulis juga melakukan wawancara terhadap Kepala Departemen Divisi Policy Service. Pada tahap mendapatkan nilai capability level penulis menggunakan framework COBIT 5. Dalam framework COBIT 5 penulis menggunakan 2 subdomain yaitu APO12 dan MEA01. Pada subdomain APO12 memiliki 6 karakter nilai yang berbeda beda sedangkan untuk MEA01 mendapatkan nilai 3,78 yang memiliki gap 1,22 dari nilai yang diharapkan perusahaan. Walupun dari nilai yang didapat sudah cukup baik, namun akan lebih baik apa bila dilakukan pengingkatan dalam analisis manajemen risiko pada perusahaan agar dapat mempertahankan posisi perusahaan dan bersaing dengan perusahaan lain yang memiliki kesamaan dalam bidang jasa .
PEMANFAATAN RUANG TERBUKA HIJAU (RTH) MELALUI PEMBERDAYAAN USAHA MIKRO KECIL DAN MENENGAH OLEH PEMERINTAH DAERAH
Authors: Fitriyah Nina Sa’idah , Purwanto Adi 
Published: December 2020

Ruang terbuka hijau publik merupakan ruang terbuka yang dimiliki dan dikelola oleh pemerintah daerah kota yang digunakan untuk kepentingan masyarakat secara umum. Merujuk pada peraturan dan fenomena sehingga penelitian ini dirasa penting karena sarana dan prasana pemerintahan Kabupaten Situbondo membangun ruang terbuka hijau dapat termanfaatkan dengan baik oleh masyarakat melalui memberdayakan UMKM masyarakat yang ada disekitar lahan tersebut. Jenis penelitian ini menggunakan penelitian deskriptif dengan metode pendekatan kualitatif. Lokasi penelitian di Kecamatan Kapongan Kabupaten Situbondo Jawa Timur. Teknik penentu informan menggunakan purposive sampling. Teknik pengumpulan data menggunakan wawancara mendalam, observasi dan study pustaka. Hasil penelitian ini menunjukkan bahwa pemanfaatan Ruang Terbuka Hijau (RTH) di Desa Kesambirampak Kecamatan Kapongan Kabupaten Situbondo sebagai berikut : 1) Segi Bidang Pendidikan yakni menduduki posisi penting dalam proses dinamika pertemuan budaya, karena melalui ruang ini dihubungkan jalinan budaya antara wilayah dan sebagai aicon desa untuk mengenal budaya desa tersebut. Dari sinilah interaksi budaya dengan segala implikasinya terjadi. Interaksi budaya ini telah memunculkan kelompok-kelompok sosial dari berbagai etnis dan membentuk kampung-kampung etnis tertentu dengan kulturasi budaya mereka yang berkembang di sekitar taman. 2) Segi Bidang Ekonomi yakni dapat meningkatakn pendapatan warga masyarakat sekitar sehingga dapat menambah pula terhadap Pendapat Asli Desa (PAD) yang berdampak pada kesejahteraan masyarakat. 3). Segi Bidang Sosial yakni sebagai wadah berkumpulnya manusia dalam melakukan segala bentuk kegiatan sehingga menghasilkan interaksi dan komunikasi antar warga sebagai wadah rekreasi keluarga yang sangat terjangkau oleh masyarakat.
PENGARUH PELATIHAN, MOTIVASI DAN KOMPETENSI TERHADAP KINERJA KARYAWAN PADA PT JASA SUMBER KARUNIA MEDAN
Authors: Sepviany Sepviany , Calvin Calvin 
Published: December 2020

PT Jasa Sumber Karunia Medan merupakan sebuah perusahaan yang bergerak dibidang pengurusan transportasi (freight forwanding). Penurunan kinerja karyawan PT Jasa Sumber Karunia Medan terlihat dari tidak tercapainya target perusahaan yang diakibatkan pelatihan yang belum optimal, motivasi dan kompetensi. Metode penelitian mengunakan kuantitatif. Populasi adalah berjumlah 168 karyawan dan sampel berjumlah 118 karyawan PT Jasa Sumber Karunia Medan. Teknik sampling yang digunakan adalah sampling random sampling. Hasil perhitungan pengujian hipotesis adanya pengaruh positif dan signifikan Pelatihan secara parsial terhadap Kinerja Karyawan pada PT Jasa Sumber Karunia Medan, adanya pengaruh positif dan signifikan Motivasi secara parsial terhadap Kinerja Karyawan pada PT Jasa Sumber Karunia Medan, adanya pengaruh positif dan signifikan Kompetensi secara parsial terhadap Kinerja Karyawan pada PT Jasa Sumber Karunia Medan dan adanya pengaruh positif dan signifikan Pelatihan, Motivasi dan Kompetensi berpengaruh secara simultan terhadap Kinerja Karyawan pada PT Jasa Sumber Karunia Medan.