bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diel cycle of sea spray aerosol concentration over vast areas of the tropical Pacific Ocean and the Caribbean Sea
Authors: Flores J. Michel , Bourdin Guillaume , Kostinski Alexander , Altaratz Orit , Dagan Guy , Lombard Fabien , Haëntjens Nils , Boss Emmanuel , Sullivan Matthew , Gorsky Gabriel , Lang-Yona Naama , Trainic Miri , Romac Sarah , Voolstra Christian , Rudich Yinon , Vardi Assaf , Koren Ilan 
Published: September 2020

Abstract
Ocean-atmosphere interactions such as sea spray aerosol (SSA) formation have a major role in the climate system, but a global-scale assessment of this micro-scale process is highly challenging. We measured high-resolution temporal patterns of SSA number concentration over the Atlantic Ocean, Caribbean Sea, and the Pacific Ocean covering 42,000 km of open ocean waters. We discovered a ubiquitous 24-hour rhythm to the number concentration, clearly seen for particle diameters > ~ 0.58 µm, with spikes at dawn and drops at dusk throughout the Pacific Ocean and Caribbean Sea, showing more than doubling of the SSA number concentration during the day than at night. No correlation with surface winds, atmospheric radiation, pollution nor oceanic physical properties were found. Instead, parallel diel patterns in particle sizes detected in near-surface waters, attributed to variations in the size of particles smaller than ~ 1 µm, point to microbial day-to-night modulation of bubble-bursting dynamics as the cause of the SSA cycle.
Whole-Exome Sequencing Identifies Somatic Mutations Associated With Lung Cancer Metastasis to the Brain
Authors: Liu Zhenghao , Zheng Meiguang , Lei Bingxi , Zhou Zhiwei , Huang Yutao , Li Wenpeng , Chen Qinbiao , Li Pengcheng , Deng Yuefei 
Published: September 2020

Abstract
Background: Lung cancer is the most aggressive cancer which representing one-quarter of all cancer-related deaths, and metastatic spread accounts for >70% of these deaths, especially brain metastasis. Metastasis associated mutations are important biomarkers for metastasis prediction and outcome improvement. Methods: In this study, we applied whole-exome sequencing to identify potential metastasis related mutation in 12 paired lung cancer and brain metastasis samples. Results: We identified 1,702 SNVs and 6,131 mutation events in 1,220 genes. Furthermore, we identified several lung cancer metastases associated genes (KMT2C, AHNAK2). A mean of 3.1 driver gene mutation events per tumor with the dN/dS of 2.13 indicating a significant enrichment for cancer driver gene mutations. Mutation spectrum analysis found lung-brain metastasis samples have more similar Ti/Tv(transition/transversion) profile with brain cancer in which C>T transitions are more frequently while lung cancer has more C>A transversion. We also found the most important tumor onset and metastasis pathways such as chronic myeloid leukemia, ErbB signaling pathway and glioma pathway. Finally, we identified a significant survival associated mutation gene ERF in both TCGA (P=0.01) and our dataset (P=0.012). Conclusion: In summary, we conducted a pairwise lung-brain metastasis based exome-wide sequencing and identified some novel metastasis related mutations which provided potential biomarkers for prognosis and targeted therapeutics.
Expression Profile of Peripheral Immune Cells-derived Coding and Long Non-coding RNAs&nbsp;in Patients With Proliferative Vitreoretinopathy
Authors: Ni Yao , Liu Fangyuan , Hu Xiao , Qin Yingyan , Zhang Zhaotian 
Published: September 2020

Abstract
Introduction: Peripheral immune response has been revealed to play a critical role in proliferative vitreoretinopathy (PVR). However, the reliable immune-related factors that are acting as prognostic indicators or therapeutic targets for PVR remain to explore further.Methods: In the current study, we applied whole-transcriptome sequencing to profile peripheral blood mononuclear cells (PBMCs) from PVR patients and also analyzed lncRNA-mRNA interactions in peripheral immune cells to explore the pathways that might mediate immunopathology and resultant retinal damage in PVR. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses and Ingenuity Pathway Analysis (IPA) were employed to classify the function of these differentially expressed genes (DEGs).Results: Compared to the controls, there were 319 genes upregulated, and 191 genes downregulated in PVR patients. GO, and KEGG enrichment analyses as well as IPA showed that these upregulated genes were significantly enriched in immune-related and infection-relate terms. Immune-related gene NFKBIA, CXCL2, and CXCL8 were detected as hub-genes in the co-expression network, while lncRNAs such as AC007032.1, AC037198.2, AL929472.2, and SLED1 were highly co-expressed with them. lncRNA-mRNA interactions analysis also showed that putative targeted genes of these differentially expressed lncRNAs were also significantly enriched in immune-related or infection-relate pathways.Conclusion: Our study highlights the transformation of immune-related genes/pathways in PVR by comparing controls, and validates several critical genes and lncRNAs, which are serving as potential diagnostic markers for PVR patients.
Characteristics of Hospital Differences in Missing of Clinical Laboratory Test Results in a Multi-hospital Observational Database Contributing to MID-NET® in Japan
Authors: Komamine Maki , Fujimura Yoshiaki , Nitta Yasuharu , Omiya Masatomo , Doi Masaaki , Sato Tosiya 
Published: September 2020

Abstract
Background: In Japan, a multiple-hospital observational database system, the Medical Information Database Network (MID-NET®), was launched for post-marketing drug safety assessments. These assessments will be based on datasets with missing laboratory results. The characteristics of missing data considering hospital differences have not been evaluated. We assessed the missing proportion and the association between missingness and a factor through case studies using a database system, a part of MID-NET®.Methods: Seven scenarios using laboratory results before the prescription of the assessed drug as baseline covariates and data from 10 hospitals of Tokushukai Medical Group were used. The missing proportion and the association between missingness and patient background were investigated per hospital. The associations were assessed using the log of adjusted odds ratio (log-aOR). Additionally, an ad hoc survey was conducted to explore other factors affecting the missingness.Results: For some laboratory tests, missing proportions varied among hospitals, such as 7.4%–44.4% of alkaline phosphatase (ALP) and 8.1%–31.2% of triglyceride (TG) among statin users. The association between missingness and affecting factors also differed among hospitals for some factors; example, the log-aOR of hospitalization associated with missingness of TG was -0.41 (95% CI, -1.06 to 0.24) in hospital 3 and 1.84 (95% CI, 1.34 to 2.34) in hospital 4. In the ad hoc survey focusing on ALP, hospital-dependent differences in the ordering system settings were observed.Conclusions: Hospital differences in missing data appeared in some laboratory tests in our multi-hospital observational database, which could be attributed to the affecting factors, including the patient background.
Does a Husband's Education Matter in Antenatal Care Visits Involvement?: Study on the Poor in Indonesia
Authors: Laksono Agung Dwi , Wulandari Ratna Dwi , Matahari Ratu 
Published: September 2020

Abstract
Background: The husband's involvement in ANC is a form of the husband's responsibility for his wife's health. This study aims to analyze the effect of the husband's education level on the husband's involvement in ANC visits among the poor in Indonesia.Methods: The study employed the 2017 Indonesian Demographic and Health Survey data. The unit of analysis was poor coupled with wives aged 15-49 years old and had been pregnant for the past five years. Samples of 6,414 couple were obtained. Besides the husband's education, other independent variables analyzed in this study were of the place of residence, age, occupation, and wife’s parity. A binary logistic regression test was occupied in the final stage.Results: The results showed that husbands who had primary education were 1.470 times more likely than no education husbands for husband's involvement in ANC visit. Husbands who have secondary education were likely 2.129 times compared to no education husband for husband's involvement. Meanwhile, a husband who has a higher education was probably 3.618 times compared to no education husband for husband's involvement. In addition to the education level, 3 other variables proved to be significantly influential on the husband's involvement in ANC visits among the people in Indonesia, namely place of residence, occupation, and wife’s parity.Conclusion: The husband's education level was a determinant of the husband's involvement in ANC visits among the poor in Indonesia. The better the education level, the more likely it is that husband's involvement in the ANC visit.
Prognostic Accuracy of the Afterload-related Cardiac Performance for 7-day Mortality Among Critical Ill Patients With Septic Shock
Authors: Chen Wei-yan , Tao Li-li , Xu Qi , Wei Xing , Chen Min-sheng 
Published: September 2020

Abstract
BackgroundSeptic patients with cardiac impairment are with high mortality. Afterload-related cardiac performance (ACP), as a new tool for diagnostic septic cardiomyopathy (SCM), still needs to be evaluated its impact on the prognosis for patients with septic shock. MethodsIn this observational retrospective study, 119 patients with septic shock undertaken PiCCO monitoring were evaluated for the effects of ACP on 7-day mortality, ICU mortality and hospital mortality. The ability of ACP, cardiac index (CI) and left ventricular ejection fraction (LVEF) to discriminate between survivors and non-survivors was tested by comparing the area under the receiver operating characteristic curve (AUROC) analysis. Multivariable logistic regression and Cox proportional hazards regression analyses were performed to assess the associations of ACP with 7-day mortality. Curve estimation was used to describe the relationship between hazard ratio (HR) of death and ACP.ResultsACP assessed at 12 hours (ACP12h) after septic shock [AUROC 0.86 (95% CI 0.79 to 0.93), P < 0.001] demonstrated significantly greater discrimination for 7-day mortality than CI [AUROC 0.67 (95% CI 0.57 to 0.78), P = 0.001 ] and LVEF [AUROC 0.53 (95% CI 0.43 to 0.64), P = 0.58] (all P < 0.001). Similarly, when adjusted with gender, APACHEII score, VIS and MAP as possible confounders, ACP12h still outperformed both CI12h and LVEF for discrimination of 7-day mortality (both P < 0.001). The superior discriminatory performance of ACP12h over both CI12h and LVEF was further maintained when considering ICU mortality and hospital mortality when considered in isolation or adjusted with the baseline prediction. Compared with normal ACP, HR for slight, moderate and severe impairment were 4.84 (1.96 to 11.96), 12.13 (4.83 to 30.43) and 32.70 (7.76 to 137.86), respectively. After adjustment for risk factor, decrease ACP still associated with increasing 7-day mortality (P = 0.001). Exponential relationship was observed between ACP12h and HR of 7-day death.ConclusionsOur results suggested that ACP may serve as a new tool for diagnosing SCM. In addition, the assessment of ACP at 12 hours after septic shock in ICU significantly improves 7-day mortality, ICU mortality and hospital mortality predictions when compared to CI and LVEF.
The Effect of Distal Radius Fractures Involving Distal Radioulnar Articular Joint on Forearm Rotation
Authors: Kong Lingde , Fu Meng , Lu Jian , Zhou Yanqing , Zhang Zuzhuo , Zhang Bing 
Published: September 2020

Abstract
Background: The objective of this study was to predict the function of forearm rotation on basis of articular surface of sigmoid notch from three-dimensional reconstruction images. Methods: We retrospectively reviewed patients who underwent volar plate fixation for intra-articular distal radius fractures (DRFs) in our institution between January 2017 and July 2019. The 3D image of sigmoid notch on fractured distal radius was reconstructed and looked up from ulnar view to determine the existence of gaps or steps. Patients with or without gaps/steps on sigmoid notch were included in case group or control group respectively. The patients’ basic data and postoperative data were collected and compared. Results: A total of 81 patients were included. There were 33 patients in case group, and 48 patients in control group. There was no significant difference between the two groups at baseline. Total range of motion (ROM) of rotation in case group and control group were 130.3±6.2 degrees and 145.3±6.7 degrees respectively (P<0.001). Percentage of rotation ROM of contralateral limb in case group and control group were 72.3±3.1% and 80.7±3.6% respectively (P<0.001). VAS during forearm rotation were 2.1±0.7 in case group, which is significantly higher than that in control group (1.5±0.5, P<0.001). Conclusion: This study proposed a new method to assess the articular surface of sigmoid notch which is based on 3D reconstruction images. With the assistance of this method, we found that gaps or steps on sigmoid notch not only limit forearm pronation rotation and supination rotation, but also cause apparent wrist pain during forearm rotation movement.
P63-Negative Pulmonary NUT Carcinoma Arising in the Elderly: A Case Report.
Authors: Numakura Satoe , Saito Koji , Motoi Noriko , Mori Taisuke , Saito Yuichi , Yokote Fumi , Kanamoto Yasuyuki , Asami Momoko , Sakai Takashi , Yamauchi Yoshikane , Sakao Yukinori , Uozaki Hiroshi , Kawamura Masafumi 
Published: September 2020

Abstract
Background: We herein describe a rare case of primary pulmonary NUT carcinoma with unusual clinical and pathological presentations. NUT carcinoma of the lung occurs near the hilum in younger adults with severe symptoms and is positive for p63. This is the first case to show negativity for p63 and is the oldest among previously reported cases of pulmonary NUT carcinoma. Case presentation: An 82-year-old man was referred for an incidental finding of an abnormal shadow at the peripheral apex of the right lung on computed tomography for a regular follow-up examination of renal cancer. Microscopically, small cell carcinoma was initially suspected; however, immunohistochemistry was not typical. NUT carcinoma with BRD4-NUT fusion was ultimately diagnosed using a NUT monoclonal antibody, fluorescence in situ hybridization, and RNA-seq. p63 protein expression was not detected. Conclusions: NUT carcinoma is rare, but lethal, and, thus, must not be overlooked. The present case suggests the importance of NUT immunohistochemistry in cases of small round cell tumors without clear lineage-specific differentiation, regardless of age, clinical symptoms, the tumor location, or p63 expression.
Perception of and Anxiety About COVID-19 Infection and Risk Behaviors for Spreading Infection: An International Comparison
Authors: Shiina Akihiro , Niitsu Tomihisa , Kobori Osamu , Idemoto Keita , Hashimoto Tasuku , Sasaki Tsuyoshi , Igarashi Yoshito , Shimizu Eiji , Nakazato Michiko , Hashimoto Kenji , Iyo Masaomi 
Published: September 2020

Abstract
Background: To control the spread of the new SARS-CoV-2 infection's disease (COVID-19), appropriate precautionary behaviors by the public should be promoted. We have been concerned about the differences among countries regarding the populations' cognitional and behavioral patterns as well as attitudes toward information sources in relation to the anxiety about the COVID-19 pandemic because knowing these differences will contribute to our understanding of the patterns of epidemic-related anxiety and behaviors, and it will help optimize future policies for preventing the second wave of the epidemic.Methods: To examine the differences among countries in their residents' perception, attitude, and precautionary behaviors toward COVID-19, we conducted a cross-sectional study through an online questionnaire survey. Adults who had been registered in Cross Marketing Inc. and living in the UK, Spain, or Japan were subjected. A total of 8,000 people stratified by age were recruited on a first-come, first-served method. Knowledge of and anxiety about COVID-19, the frequency and credibility of several information sources, and the magnitude of each precautionary behavior were examined in the questionnaire on March 27–28, 2020 in Japan and April 17–21 in the UK and Spain.Results: Compared to Japan, the knowledge and anxiety level and the frequency of precautionary behaviors were higher in the UK and Spain. Participants with infected acquaintances were more concerned about COVID-19. However, participants in the UK rarely wore a medical mask. Participants in the UK and Spain were eager to get information about COVID-19 compared to those in Japan. The participants in Spain tended not to trust official information and to believe specialists' comments instead.Conclusion: The urgency of the spread of COVID-19, cultural backgrounds, and recent political situations appear to contribute to the differences among countries revealed herein.
Strategies to Inform Innovations in Continence Care for People Living with Dementia in the Acute Hospital Setting: A Mixed Methods Narrative Synthesis Review
Authors: Edwards Deborah , Harden Jane , Jones Aled , Featherstone Katie 
Published: September 2020

Abstract
Background: People living with dementia are at significant risk of developing urinary and/or faecal incontinence but are also at risk of functional incontinence or being labelled as being incontinent. Despite the growing population of PLWD and importance of continence care little is known about the appropriate management, organisation, and interactional, strategies for PLWD admitted to acute hospitals. This mixed methods narrative systematic review sought to identify successful strategies across all care settings that could then be used to inform innovations in continence care for PLWD in the acute hospital setting.Methods: In phase 1 a scoping search of two electronic databases (MEDLINE and PSYCinfo) and a consultation with stakeholders was undertaken. Findings from were presented to the project steering and two priority areas for phase 2 were identified which were communication and individualised care plans. In phase 2 eight databases and relevant UK government and other organisational websites were searched for English language citations from inception to August 2020. Critical appraisal was conducted using the Mixed Methods Appraisal Tool (MMA Version 11). Thematic synthesis was employed and the strength of synthesised findings for the intervention studies was assessed using the GRADE approach and the and confidence in synthesised qualitative and survey findings was assessed using the CERQual tool. Results: In phase 1, 1348 citations were found and 75 included. In phase 2, 6247 citations were found 14 research studies and 14 policy and guidance documents were included. The quality of studies varied. Material was synthesized in order to identify the facilitators and barriers around developing communication strategies and individualised management plans in response to the continence needs of PLWD.Conclusions: Recognising that PLWD are not always able to communicate their continence needs verbally is important. Incorporating interpersonal and communication skills into the context of continence care within training for those working with this patient group is crucial for continence to be maintained during an acute admission. Continence care in the acute setting should be tailored to the individual and be developed in partnership with staff and caregivers.Systematic review registration: PROSPERO: CRD42018119495
Tuberculosis Incidence Trends from 1990 to 2017 Highlight Impact of Drug Resistance: Results from the Global Burden of Disease Study
Authors: Ou Zejin , He Wenqiao , Yu Danfeng , Li Yongzhi , Liang Yuanhao , Zhang Minyi , He Huan , Gao Yuhan , Wu Fei , Chen Qing 
Published: September 2020

Abstract
Objectives This study aimed to determine the global incidence trends of tuberculosis (TB) from 1990 to 2017.Methods Data was obtained from the Global Burden of Disease (GBD) study. The estimated annual percentage changes (EAPCs) were calculated with the age-standardised incidence rate (ASIR) to estimate trends in incidence of TB, including multidrug-resistant TB (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).Results Globally, the number of TB cases was 8965.81×103 in 2017, with a 9.42% increase since 1990. The ASIR for TB showed a decreasing trend from 1990 to 2017 (EAPC = −1.19, 95% confidence interval [CI]: −1.32 to −1.07). Meanwhile, decreasing trends were observed in 162 countries/territories, particularly in Ethiopia and China where EAPCs were −4.51 (95%CI: −5.22 to −3.80) and −4.21 (95%CI: −4.98 to −3.44), respectively. However, obvious increasing trends of MDR-TB cases occurred in areas with low and low-middle sociodemographic indexes (SDI), with EAPCs of 7.97 (95%CI: 2.47 to 13.75) and 6.30 (95%:1.17 to 11.68), respectively. The ASIR for XDR-TB showed pronounced increasing trends globally from 1991 to 2017, with an EAPC of 11.74 (95%CI: 7.50 to 16.16). The largest rising trends of XDR-TB were observed in Kyrgyzstan (EAPC = 31.06, 95%CI: 23.07 to 39.57), followed by Azerbaijan and Uzbekistan.Conclusions There was a decreasing trend for TB incidence worldwide, although it was more pronounced in specific countries and regions. However, the rapidly rising trends of MDR-TB and XDR-TB cases in low and low-middle SDI areas and countries may have an adverse impact on the global control of TB.
Femtosecond quantum dynamics of excited-state evolution of halide perovskites: Quantum chaos of molecular cations
Authors: Lee Yeonghun , Kim Hyungjun , Hong Ki-Ha , Cho Kyeongjae 
Published: September 2020

Abstract
The excited state quantum dynamics of the organic cation in hybrid perovskites are investigated using the time-dependent density functional theory (TDDFT). The time-dependent non-adiabatic bond fluctuation behaviors reveal that the energy relaxation follows different pathways depending on the chemical bonding characteristics and energy transfer modes within the cation molecule, which can fundamentally affect its photostability. For the ammonium-group-containing cations, such as methylammonium (MA) or ethylammonium (EA), local vibrational modes survive for a long time. However, as their lowest unoccupied molecular orbital (LUMO) having π* characters, the amidinium-group-containing cations, such as formamidinium (FA) or guanidinium (GA), efficiently dissipate deposited energy via chaotic intramolecular vibrational energy redistribution (IVR). The distinct dynamic behaviors of A-site molecular cations are closely related to the quantum ergodicity, which can bring enhanced photochemical stability of FA and GA compared to MA and EA. Our theoretical investigation reveals the quantum chaos origin of better light stability of FA-based perovskites and serves the future research direction of the A-site engineering for better solar cells and light-emitting devices.