bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overall mortality in older people receiving physician-led home visits: a multicentre prospective study in Japan
Authors: Kaneko Makoto , Watanabe Takamasa , Fujinuma Yasuki , Yokobayashi Kenichi , Matsushima Masato 
Published: December 2020

Abstract

Background
Japan has the most rapidly ageing population in the world. The Japanese government has, therefore, promoted physician-led home health care for frail and disabled people.

Objectives
To describe mortality among older people receiving physician-led health care at home or at a nursing home in Japan and to identify risk factors.

Methods
This was a multicentre prospective cohort study. Participants were aged ≥65 years and had started to receive regular physician-led health care at home or at nursing homes from 13 facilities between 1 February 2013 and 31 January 2016. The observation period ended on 31 January 2017. We used a biopsychosocial approach for exploratory analysis of 13 variables to identify mortality risk factors.

Results
The median (25th to 75th percentile) observation time was 417 (121–744) days. Of 825 participants, 380 died. The total cumulative survival for 180, 360, 720 and 1440 days was 73.4% (95% confidence interval: 70.2–76.3), 64.2% (60.8–67.5), 52.6% (48.8–56.3) and 34.6% (23.5–46.0). The Kaplan–Meier cumulative survival curve showed a steep drop during the first 6 months of observation. A multivariate Cox proportional hazard model showed that sex (male), high Charlson Comorbidity Index score, low serum albumin level, low Barthel Index score, receipt of oxygen therapy, high Cornell Scale for Depression in Dementia score and non-receipt of public assistance were associated with mortality.

Conclusions
Overall mortality in physician-led home visits in Japan was described and mortality risk factors identified. Public assistance receipt was associated with lower mortality.
Preferential dipeptide incorporation of Porphyromonas gingivalis mediated by proton-dependent oligopeptide transporter (Pot)
Authors: Ohara-Nemoto Yuko , Sarwar Mohammad Tanvir , Shimoyama Yu , Kobayakawa Takeshi , Nemoto Takayuki K 
Published: December 2020

ABSTRACT
Multiple dipeptidyl-peptidases (DPPs) are present in the periplasmic space of Porphyromonas gingivalis, an asaccharolytic periodontopathic bacterium. Dipeptides produced by DPPs are presumed to be transported into the bacterial cells and metabolized to generate energy and cellular components. The present study aimed to identify a transporter responsible for dipeptide uptake in the bacterium. A real-time metabolic analysis demonstrated that P. gingivalis preferentially incorporated Gly–Xaa dipeptides, and then, single amino acids, tripeptides and longer oligopeptides to lesser extents. Heterologous expression of the P. gingivalis serine/threonine transporter (SstT; PGN_1460), oligopeptide transporter (Opt; PGN_1518) and proton-dependent oligopeptide transporter (Pot; PGN_0135) genes demonstrated that Escherichia coli expressing Pot exclusively incorporated Gly–Gly, while SstT managed Ser uptake and Opt was responsible for Gly–Gly–Gly uptake. Dipeptide uptake was significantly decreased in a P. gingivalis Δpot strain and further suppressed in a Δpot-Δopt double-deficient strain. In addition, the growth of the Δpot strain was markedly attenuated and the Δpot-Δopt strain scarcely grew, whereas the ΔsstT strain grew well almost like wild type. Consequently, these results demonstrate that predominant uptake of dipeptide in P. gingivalis is mostly managed by Pot. We thus propose that Pot is a potential therapeutic target of periodontal disease and P. gingivalis-related systemic diseases.
Environmental fluctuations and their effects on microbial communities, populations and individuals
Authors: Nguyen Jen , Lara-Gutiérrez Juanita , Stocker Roman 
Published: December 2020

ABSTRACT
From the homeostasis of human health to the cycling of Earth's elements, microbial activities underlie environmental, medical and industrial processes. These activities occur in chemical and physical landscapes that are highly dynamic and experienced by bacteria as fluctuations. In this review, we first discuss how bacteria can experience both spatial and temporal heterogeneity in their environments as temporal fluctuations of various timescales (seconds to seasons) and types (nutrient, sunlight, fluid flow, etc.). We then focus primarily on nutrient fluctuations to discuss how bacterial communities, populations and single cells respond to environmental fluctuations. Overall, we find that environmental fluctuations are ubiquitous and diverse, and strongly shape microbial behavior, ecology and evolution when compared with environments in which conditions remain constant over time. We hope this review may serve as a guide toward understanding the significance of environmental fluctuations in microbial life, such that their contributions and implications can be better assessed and exploited.
The Differential Impact of Retirement on Informal Caregiving, Volunteering, and Grandparenting: Results of a 3-Year Panel Study
Authors: Grünwald Olga , Damman Marleen , Henkens Kène 
Published: December 2020

Abstract

Objectives
Research on retirees’ engagement in informal caregiving, formal volunteering, and grandparenting often views retirement as a permanent exit from the workforce. Retirement processes are, however, increasingly diverse: some retire fully while others remain in paid work after retirement from a career job. A relevant but understudied question is how these different retirement processes relate to changes in engagement in unpaid productive activities. Building on role theory, we hypothesize that full and working retirees face different consequences of retirement and, therefore, differ in engagement in unpaid productive activities.

Method
We analyze data that were collected in 2015 and 2018 among 4,882 Dutch individuals aged 60–65 and employed at baseline. Around half had fully retired at follow-up and 10% worked after their retirement. At follow-up, more respondents are regularly volunteering (from 17% to 27%) and grandparenting (from 39% to 53%) than at baseline, while caregiving remains rather stable (from 33% to 30%).

Results
Conditional change models show that full retirement is associated with an increased likelihood of volunteering and grandparenting, but not caregiving. Engagement in postretirement work is related to an increased likelihood of looking after the grandchildren, but not to volunteering or providing informal care.

Discussion
Our findings suggest that volunteering is important for replacing weak ties after full retirement, while grandparenting might be a new, central role in retirement—irrespective of work engagement. Retirees seem to engage in unpaid productive activities for different reasons.
The ethics of preconception expanded carrier screening in patients seeking assisted reproduction
Authors: de Wert Guido , van der Hout Sanne , Goddijn Mariëtte , Vassena Rita , Frith Lucy , Vermeulen Nathalie , Eichenlaub-Ritter Ursula ,   ESHRE Ethics Committee, Blanchet Valérie , D’Angelo Arianna , de Wert Guido , Eguizabal Cristina , Eichenlaub-Ritter Ursula , Frith Lucy , Geril Annick , Goddijn Mariëtte , Heindryckx Bjorn , Mertes Heidi , Ombelet Willem , Rautakallio-Hokkanen Satu , Strowitzki Thomas , Tapanainen Juha , Tarlatzis Basil C , Van den Eede Bruno , Westin Cecilia 
Published: December 2020

ABSTRACTExpanded carrier screening (ECS) entails a screening offer for carrier status for multiple recessive disorders simultaneously and allows testing of couples or individuals regardless of ancestry or geographic origin. Although universal ECS—referring to a screening offer for the general population—has generated considerable ethical debate, little attention has been given to the ethics of preconception ECS for patients applying for assisted reproduction using their own gametes. There are several reasons why it is time for a systematic reflection on this practice. Firstly, various European fertility clinics already offer preconception ECS on a routine basis, and others are considering such a screening offer. Professionals involved in assisted reproduction have indicated a need for ethical guidance for ECS. Secondly, it is expected that patients seeking assisted reproduction will be particularly interested in preconception ECS, as they are already undertaking the physical, emotional and economic burdens of such reproduction. Thirdly, an offer of preconception ECS to patients seeking assisted reproduction raises particular ethical questions that do not arise in the context of universal ECS: the professional’s involvement in the conception implies that both parental and professional responsibilities should be taken into account. This paper reflects on and provides ethical guidance for a responsible implementation of preconception ECS to patients seeking assisted reproduction using their own gametes by assessing the proportionality of such a screening offer: do the possible benefits clearly outweigh the possible harms and disadvantages? If so, for what kinds of disorders and under what conditions?
Conflict-Related Sexual Violence and the Re-Escalation of Lethal Violence
Authors: Nagel Robert U 
Published: December 2020

AbstractTo what extent does sexual violence influence the likelihood of re-escalating lethal violence after a period of inactivity? Despite a substantive body of research that explores conflict recurrence, the literature has largely neglected the role of rebel group dynamics. I address this gap arguing that reports of rebel sexual violence in periods deemed inactive because of low numbers of casualties are associated with greater risks of escalating lethal violence. Specifically, building on research that shows an association between recruitment and rape as a socialization method during civil war, I argue that reports of sexual violence indicate that rebels are maintaining and mobilizing fighters in inactive conflict years. I systematically test this argument on all inactive intrastate conflict years from 1989 to 2015 using the updated Sexual Violence in Armed Conflict dataset and Armed Conflict Termination dataset. The results provide robust support for the argument that a re-escalation of lethal violence following inactive periods is more likely when rebels are reported to perpetrate sexual violence in both active and subsequent inactive periods.
Practical isogeometric shape optimization: parametrization by means of regularization
Authors: Limkilde A , Evgrafov A , Gravesen J , Mantzaflaris A 
Published: December 2020

Abstract
Shape optimization based on isogeometric analysis (IGA) has gained popularity in recent years. Performing shape optimization directly over parameters defining the computer-aided design (CAD) geometry, such as the control points of a spline parametrization, opens up the prospect of seamless integration of a shape optimization step into the CAD workflow. One of the challenges when using IGA for shape optimization is that of maintaining a valid geometry parametrization of the interior of the domain during an optimization process, as the shape of the boundary is altered by an optimization algorithm. Existing methods impose constraints on the Jacobian of the parametrization, to guarantee that the parametrization remains valid. The number of such validity constraints quickly becomes intractably large, especially when 3D shape optimization problems are considered. An alternative, and arguably simpler, approach is to formulate the isogeometric shape optimization problem in terms of both the boundary and the interior control points. To ensure a geometric parametrization of sufficient quality, a regularization term, such as the Winslow functional, is added to the objective function of the shape optimization problem. We illustrate the performance of these methods on the optimal design problem of electromagnetic reflectors and compare their performance. Both methods are implemented for multipatch geometries, using the IGA library G+Smo and the optimization library Ipopt. We find that the second approach performs comparably to a state-of-the-art method with respect to both the quality of the found solutions and computational time, while its performance in our experience is more robust for coarse discretizations.
How the Eyes Connect to the Heart: The Influence of Eye Gaze Direction on Advertising Effectiveness
Authors: To Rita Ngoc , Patrick Vanessa M 
Published: December 2020

AbstractA model’s eyes are a powerful and ubiquitous visual feature in virtually any advertisement depicting a person. But does where the ad model’s eyes look matter? Integrating insights from social psychology and performance and visual art theory, we demonstrate that when the ad model’s gaze is averted (looking away from the viewer), the viewer is more readily transported into the ad narrative and responds more favorably to the ad than when the ad model’s gaze is direct (looking directly at the viewer). Five multi-method experiments (field and lab studies) illustrate that averted gaze (direct gaze) enhances narrative transportation (spokesperson credibility) to boost the effectiveness of emotional (informative) ads. Study 1 is a Facebook field study that demonstrates the effect of averted (vs. direct) gaze direction on advertising effectiveness using a real brand. Studies 2a and 2b implicate enhanced narrative transportation as the underlying process mechanism by measuring (study 2a) and manipulating (study 2b) narrative transportation. Studies 3a and 3b examine ad contexts in which direct gaze can enhance ad effectiveness: when the ad has informational (vs. emotional) appeal (study 3a), and when the viewer prefers not to identify with the negative emotional content of the ad (study 3b).
Fault and horizon automatic interpretation by CNN: a case study of coalfield
Authors: Guo Yinling , Peng Suping , Du Wenfeng , Li Dong 
Published: December 2020

Abstract
A convolutional neural network (CNN) is a powerful tool used for seismic interpretation. It does not require manual intervention and can automatically detect geological structures using the pattern features of the original seismic data. In this study, we presented the development history of seismic interpretation and the application of CNN in seismic exploration. We proposed a set of CNN prediction methods and processes for coalfield seismic interpretation and realised automatic interpretation of faults and horizons based on the relationship between faults and horizons. We defined a CNN model training method based on structural geological modelling, which allowed rapid and accurate establishment of fault and horizon labels by using structural modelling. We used two examples to verify the accuracy of the algorithm, one to test for synthetic 3D seismic data and one to test for real coalfield seismic data. The results showed that CNNs can effectively predict both faults and horizons at the same time and has high accuracy. Thus, CNNs are potentially novel interpretation tools for coalfield seismic interpretation.
Effect of nitrogen-containing bisphosphonates on osteoclasts and osteoclastogenesis: an ultrastructural study
Authors: Takagi Yoshitoki , Inoue Satoshi , Fujikawa Kaoru , Matsuki-Fukushima Miwako , Mayahara Mitsuori , Matsuyama Kayo , Endo Yasuo , Nakamura Masanori 
Published: December 2020

Abstract
We have previously indicated that a single injection of alendronate, one of the nitrogen-containing bisphosphonates (NBPs), affects murine hematopoietic processes, such as the shift of erythropoiesis from bone marrow (BM) to spleen, disappearance of BM-resident macrophages, the increase of granulopoiesis in BM and an increase in the number of osteoclasts. NBPs induce apoptosis and the formation of giant osteoclasts in vitro and/or in patients undergoing long-term NBP treatment. Therefore, the time-kinetic effect of NBPs on osteoclasts needs to be clarified. In this study, we examined the effect of alendronate on mouse osteoclasts and osteoclastogenesis. One day after the treatment, osteoclasts lost the clear zone and ruffled borders, and the cell size decreased. After 2 days, the cytoplasm of osteoclasts became electron dense and the nuclei became pyknotic. Some of the cells had fragmented nuclei. After 4 days, osteoclasts had euchromatic nuclei attached to the bone surface. Osteoclasts had no clear zones or ruffled borders. After 7 days, osteoclasts formed giant osteoclasts via the fusion of multinuclear and mononuclear osteoclasts. These results indicate that NBPs affect osteoclasts and osteoclastogenesis via two different mechanisms.
Readdressing the Needs of Cancer Survivors During COVID-19: A Path Forward
Authors: Jones Jennifer M , Saeed Hina , Katz Matthew S , Lustberg Maryam B , Forster Victoria J , Nekhlyudov Larissa 
Published: December 2020

Abstract
The growing number of cancer survivors and the high prevalence of cancer-related physical and psychosocial effects pose important and pressing challenges to health systems. The coronavirus disease 2019 (COVID-19) pandemic has led to further stressors on cancer survivors and health care systems. As the pandemic continues to have substantial impact on the world, it is critical to focus attention on the health care needs of cancer survivors. In this commentary, we propose an adoption of essential steps that should be part of a continuous adaptive approach to promote effective cancer survivorship care during ongoing COVID-19 waves and beyond.
Ruptured sinus of Valsalva aneurysm with ventricular septal defect complicated by preoperative cardiogenic shock, cardiac arrest, and multiple organ dysfunction: a rare survivor and review of contemporary literature
Authors: Furui Masato , Dillon Jeswant , Akhtar Kunwar Muhammad Aqeel , Bin Ja’apar Ahmad Nazrin 
Published: December 2020

Abstract
Sinus of Valsalva aneurysm (SVA) is a relatively rare cardiac condition, in which the patient is usually asymptomatic. However, once this aneurysm ruptures, patients present with acute symptoms of heart failure. Timely surgical intervention is essential.
We present the case of a 27-year-old woman, who had a ruptured SVA with a ventricular septal defect (VSD). The patient collapsed before the emergency operation and needed cardiopulmonary resuscitation. The patient required preoperative high inotoropic support and postoperative management was difficult because of multiple organ dysfunction. However, the patient recovered after using inhaled nitric oxide and veno-venous hemofiltration and tracheostomy, and was discharged with no further complications. To the best of our knowledge, no such case of a ruptured SVA with VSD, complicated by preoperative cardiac arrest and multiple organ dysfunction that culminated in a successful recovery, has been reported to date.
Comparison of Air Force, Army, and Navy Emergency Medical Technician Candidates’ Performance on the National Registry Cognitive Examination
Authors: Mercer Christopher B , Cash Rebecca E , Rivard Madison K , Chrzan Kirsten , Harper Stephen , Walrath Benjamin , Carmichael Jennie L , Panchal Ashish R 
Published: December 2020

ABSTRACTIntroductionMilitary medics function similarly to civilian emergency medical technicians (EMTs); however, they perform their emergency medical care in combat zones and military treatment facilities. Both civilian and military EMTs must take and pass the National Registry of EMT’s cognitive examination to be certified as a Nationally Registered EMT; however, there is a discrepancy in requirements for obtaining and maintaining National EMT Certification between the military branches of the DoD. In our study, we aimed to compare the performance of the U.S. Air Force (USAF), U.S. Army (USA), and U.S. Navy (USN) EMT candidates on the National EMT Certification cognitive examination from 2015 to 2017.Materials and MethodsWe performed a cross-sectional analysis of the National Registry of EMT’s database for the examination results of all military EMT candidates who attempted the National EMT Certification cognitive examination between January 1, 2015, and December 31, 2017. First and cumulative third attempt pass rates and cognitive performance from mean ability estimates (MAEs) on the examination were assessed. Descriptive statistics were calculated and comparisons between branches with regard to passing rates and MAEs were made using chi-square tests and ANOVA, respectively, at the alpha level of 0.05.ResultsDuring the 3-year study period, a total of 3,642 USAF, 14,050 USA, and 1,187 USN candidates attempted the cognitive examination one or more times. The USA candidates demonstrated the highest first attempt pass rates (2015: 78%; 2016: 78%; and 2017: 81%) followed by the USAF candidates (2015: 58%; 2016: 62%; and 2017: 64%) and the USN candidates (2015: 41%; 2016: 56%; and 2017: 62%). The cumulative third attempt pass rates followed a similar trend (e.g., USA: 2015: 94%; 2016: 95%; and 2017: 96%). These differences by branch were statistically significant for each year (P &lt; .001). The overall test MAE scores also differed by branch, but only the USN candidates’ MAE scores differed by year. The USA candidates demonstrated the highest MAE from 2015 to 2017 (523) followed by the USAF (489) and the USN (464) candidates. The overall test MAE scores for the USN candidates improved over the study period (2015: 449; 2016: 475; and 2017: 479, P &lt; .001).ConclusionMilitary EMT candidates had different performances on the EMT cognitive examination between branches. The USA candidates demonstrated higher pass rates and cognitive performance on the examination compared to their counterparts from the USAF and USN from 2015 to 2017. Further work should be directed at defining the cause of the differences in military EMT candidate performance and determining the characteristics that impact these differences.
Perforated Appendicitis: An Unintended Consequence During the Coronavirus-19 Pandemic
Authors: Wang Andrew W , Prieto James , Ikeda Daniel S , Lewis Paul R , Benzer Emily M , Van Gent Jan-Michael 
Published: December 2020

ABSTRACT

Background
The coronavirus disease 2019 (COVID-19) pandemic has had major clinical impact across the globe. Delayed presentation for medical emergencies has been noted by the medical community. There has been limited reporting on the impact for the care for emergent surgical conditions. We sought to describe the effect of the global pandemic on the presentation and outcomes for the most common urgent general surgery disease process, acute appendicitis.

Methods
We performed a retrospective review of patients admitted to the United States Naval Hospital Okinawa during the COVID-19 pandemic, from January 2020 to May 2020 (COVID cohort), and compared them to a historical cohort (pre-COVID cohort) over the prior 2 years. Demographics, clinical presentation data, and interventions were collected.

Results
Of the 80 patients with appendicitis, 20% presented perforated. Most patients were male (71%), presented with 1 day of symptoms and had a length of stay of 1 to 2 days. Comparing groups, 13% of the pre-COVID group vs. 31% of the COVID cohort presented perforated (P = .04), with a symptom duration of 1.6 vs. 2.7 days before presentation (P = .075), respectively.

Conclusions
The COVID-19 pandemic and the global systematic response has impacted unrelated medical and surgical conditions. At our overseas military hospital with minimal disease burden, we observed a delay in presentation for acute appendicitis with a higher incidence of perforation. Patients should be empowered to continue to seek care for urgent and emergent medical and surgical conditions so that they are not harmed by fear of COVID-19 rather than by COVID-19 itself.