bluuebunny/crossref_metadata_2025_split huggingface dataset:
Розробка та дослідження імітаційної моделі процесу термовакуумної обробки харчових продуктів як об’єкту керування
Authors: Мазур О. В. , Грабанова К. Є. , Гудзь С.С. 
Published: May 2020

Перевагою теплової обробки харчових продуктів в вакуумі є можливість реалізації процесів в бескисневому середовищі. Теплова обробка в таких умовах сприяє збереженню поживних речовин, вітамінів, антиоксидантів, фарбувальних пігментів сировини, смакових якостей і т.п., а також збільшенню терміну застосування допоміжних речовин і зберігання готових продуктів в порівнянні з обробкою при атмосферному тиску. Роботу присвячено побудові імітаційної моделі процесу теплової обробки харчових продуктів в вакуумному термоелектричному котлоагрегаті. Проведено аналіз технологічного процесу як об’єкту керування. Виконана декомпозиція технологічного процесу на окремі субпроцеси та розроблена його загальна структура з основними взаємозв’язками між моделями окремих вузлів. Розроблено моделі термоелектричного перетворювача, пароводяної сорочки, випарника, паропроводу, конденсатора, радіатора з повітряним охолодженням, вакуумної системи, збірника конденсата, . Ці моделі, а також загальна імітаційна модель процесу реалізовані в середовищі Matlab Simulink. Для перевірки імітаційної моделі технологічного процесу термовакуумної обробки на адекватність проведені її тестові дослідження як об’єкту керування. В статті наведені отримані в ході проведених віртуальних експериментів, квазістатичні та динамічні характеристики процесу за основними каналами перетворень. Результати тестування імітаційної моделі процесу теплової обробки харчових продуктів в вакуумі як обєкту керування свідчать про те, що вона досить адекватно відтворює основні параметри складних теплових та тепломасообміних процесів, що протікають в малогабаритному вакуумному термоелектричному котлоагрегаті, і може бути використана при дослідженнях його як об’єкту керування, а також при розробці та тестуванні алгоритмів керування процесом.
A Multicenter Randomized Three-Arm Phase II Study of (1) Everolimus, (2) Estrogen Deprivation Therapy (EDT) with Leuprolide + Letrozole, and (3) Everolimus + EDT in Patients with Unresectable Fibrolamellar Carcinoma
Authors: El Dika Imane , Mayer Robert J. , Venook Alan P. , Capanu Marinela , LaQuaglia Michael P. , Kobos Rachel , O'Neill Allison F. , Chou Joanne F. , Ly Michele , Ang Celina , O'Reilly Eileen M. , Gordan John D. , Abou-Alfa Ghassan K. 
Published: May 2020

Abstract

Trial Information
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Lessons Learned
FLC is a complex cancer with many implicated oncogenic pathways. Single or dual targeting does not appear to alter the natural history of the cancer, and novel therapeutics are needed. Estrogen deprivation therapy with letrozole and leuprolide, alone or in combination with the mTOR inhibitor, everolimus, did not demonstrate clinical activity in advanced fibrolamellar carcinoma. The study drugs were well tolerated when administered as single agents or in combination in this patient population. This study demonstrates that, despite the rarity of FLC, multicenter therapeutic clinical trials are feasible and support the value of this consortium.

Background
Fibrolamellar carcinoma (FLC) is an uncommon malignancy in young people and is sometimes associated with pregnancy and oral contraceptive use. Immunohistochemical staining and genetic profiling of FLC tumor specimens have revealed aromatase overexpression. The overexpression of mTOR and S6 kinase has been noted in 25% of FLC. On the basis of interaction between estrogen and the PI3K/Akt/mTOR pathway, we hypothesized that suppression of estrogen and mTOR signaling could have antineoplastic activity in FLC.

Methods
Patients were randomized to arm A (everolimus), arm B (letrozole/leuprolide; estrogen deprivation therapy [EDT]), or arm C (everolimus/letrozole/leuprolide). Upon disease progression, patients in arm A or B could proceed to part 2 (everolimus/letrozole/leuprolide). The primary endpoint was progression-free survival (PFS) at 6 months (PFS6) assessed using a Simon's minimax two-stage design, hypothesizing an improvement in PFS6 from 40% to 64% with the study regimen.

Results
Twenty-eight patients were enrolled. An unplanned analysis was performed because of perceived concern for lack of efficacy. Stable disease was observed in 9 of 26 evaluable patients (35%). PFS6 was 0%. Median overall survival (OS) was 12.4 months (95% confidence interval [CI], 7.4–20.9) for the whole study cohort. Grade 3 adverse events in ≥10% of patients were nausea (11%), vomiting (11%), anemia (11%), elevated aspartate transaminase (AST; 32%), alanine transaminase (ALT; 36%), and alkaline phosphatase (14%). All 28 patients experienced an event for PFS outcome, and four deaths were due to disease progression.

Conclusion
Neither EDT nor mTOR inhibition improved outcomes in FLC. Other treatment strategies are needed.
Experiencia clínica con la aplicación del dispositivo intrauterino TCu 380A en el período postparto
Authors: Ruiz Povea Jaime Fernando , Gómez Sánchez Pío Iván 
Published: May 2020

La inserción de dispositivos intrauterinos (DIUs) en el período postparto (hasta 48 h del parto) cuenta con grandes ventajas logísticas. En el presente estudio, de tipo descriptivo y retrospectivo se analizan los casos de 315 pacientes a quienes le fue impartida consejería en planificación familiar, e insertado un DIU TCu380A en el período postparto. Se siguieron criterios de exclusión recomendados por la OMS y las pacientes con alto riesgo de infección puerperal. La inserción se realizó con pinzas de anillo largas y en el 71%, de los casos fue llevada a cabo por personal en entrenamiento. Un total de 145 pacientes tuvieron seguimiento a seis meses, y entre ellas se documentó un caso de embarazo, 3 casos de infección genital alta, 13 expulsiones y seis casos de retiro por sangrado o dolor. Se considera que, aún cuando el bajo seguimiento constituye una limitante de importancia en el estudio de la validez, en la presente serie de casos el método puede considerarse efectivo y seguro; son necesarios estudios adicionales que confirmen comparativamente las ventajas del método.
Entrenamiento y certificación en endoscopia ginecológica
Authors: Argüello Argüello Ramiro 
Published: May 2020

El desarrollo de la Endoscopia ginecológica en los últimos años ha hecho que los procedimientos operatorios laparohisteroscópicos sean cada vez más frecuentes, y en Colombia un 60% a 70% de los procedimientos que antiguamente se realizaban exclusivamente mediante Laparotomía se pueden hacer ahora mediante Cirugía Laparoscópica. La Sociedad Colombiana de Obstetricia y Ginecología (S.C.O.G.) ha trabajado desde 1.995 en la Reglamentación de la Endoscopia Ginecológica en Colombia y con este propósito creó la Comisión de Certificación en Endoscopia Ginecológica. Se presentan los logros alcanzados por esta Comisión en los últimos años. Se presenta la clasificación actual de los procedimientos Endoscópicos Ginecológicos en Colombia y los requisitos exigidos por la S.C.O.G. para la certificación de los niveles básico, avanzado y experto. Finalmente se invita a los ginecólogos interesados en el tema a ponerse en contacto con la Sede Departamental o Nacional de la S.C.O.G. con el fin de ampliar la información presentada.
Programas de postgrado en Ginecobstetricia: El Residente toma la palabra
Authors: Cano Quiñones Alvaro , Sarmiento Rodríguez Andrés 
Published: May 2020

Pocas veces se le pide al residente la opinión acerca de su programa de especialización. Usualmente éste se califica de acuerdo con la óptica del docente, del hospital o de las directivas universitarias; sin tener en cuenta la opinión de la persona que directamente experimenta el contenido del programa. Es menos frecuente aun que se intente describir el perfil del residente de ginecobstetricia colombiano: sus deficiencias, fortalezas, vicios de formación y otras características que pueden afectar su desempeño.
Resultado obstétrico en embarazo prolongado no complicado
Authors: Abotalib Z. M. , Soltan M. H. , Chowdhury N. , Adelusi B. 
Published: May 2020

Objetivo: Estudiar y comparar el resultado obstétrico en embarazos a término y embarazos prolongados no complicados.Métodos: El estudio fue una revisión retrospectiva de 596 casos. Se analizaron las historias de 286 pacientes con embarazos prolongados no complicados (≥42 semanas) y 310 pacientes con embarazos normales a término (37 a< 42 semanas) se usó el paquete Gold Stat para la codificación y análisis estadísticos.Resultados: No hubo morbilidad ni mortalidad fetal entre los dos grupos. Sin embargo el número de abortos previos fue significativamente mayor en los embarazos prolongados comparados con los embarazos a término. En forma similar, los pesos fetal y placentario, tasas de inducción del trabajo de parto y tasas de parto operatorio fueron significativamente mayores en los embarazos prolongados. Sin embargo, no hubo diferencias significativas entre las pacientes quienes fueron inducidas y aquellas que tuvieron parto espontáneo entre los embarazos prolongados.Conclusiones: No hay duda de que el embarazo prolongado se puede asociar con ciertos factores de riesgo. Sin embargo, no hay variable de resultado para justificar la inducción o no de aquellos embarazos que son prolongados.
POR UNA DEFINICIÓN COMÚN DE DESARROLLO SOSTENIBLE MÉXICO-BRASIL: ESTUDIO DE CASO A PARTIR DE LOS RESPECTIVOS TRIBUNALES NACIONALES
Authors: García López Tania , Bergamaschine Mata Diz Jamile , Faria Thomé da Silva Romeu 
Published: May 2020

La definición del principio de desarrollo sostenible, aunque ya muy abordada por la doctrina, merece ser objeto de atención, dado su amplio alcance, contenido y destinatarios. De esta manera, el presente trabajo tiene como objetivo establecer el marco conceptual, aunque de manera preliminar, sobre tales aspectos del principio para verificar su aplicación, a través de un estudio de caso, en los tribunales superiores de México (Tribunal Constitucional) y en Brasil (Tribunal Federal Supremo), sin embargo, sin ánimo de comparar ambos sistemas, sino de verificar la aplicabilidad del principio del desarrollo sostenible. Se utilizó el método deductivo, con técnica de investigación bibliográfica y estudio de caso, para lograr el debido tratamiento principiologico por parte de los estados mencionados. Finalmente, se concluye que existe efectividad judicial para lograr los mencionados supuestos y planteamientos del principio, aunque su mitigación se puede verificar frente a determinadas hipótesis, como se analizará.
Differences of Indirect MAR Test in the Unexplained Infertile and Fertile Couples
Authors: Ramadhona Nur Hafiz , Ginting Aucky , Lunardhi Hamdani 
Published: May 2020

Infertility is the inability of a partner to get pregnant after regular sexual intercourse without contraception for 12 months. Based on the cause, male infertility is caused by genetic, hormonal, infectious, sexual, and unexplained infertility. However, many infertile couples are classified into unexplained infertility without an antisperm antibody (ASA) immunological examination. This study aimed to prove that couples classified as unexplained infertility can be caused by ASA wives. This was an observational study with a cross sectional study design. The sample consisted of 2 groups, in which the first group consisted of 36 fertile couples and the second group consisted of 35 unexplained infertility couples. All samples were carried out indirect MAR test to obtain the ASA value of the wife. If the wife's ASA value was >40%, the ASA results were positive. Conversely, if the ASA value was <40%, the ASA results were negative. From these 2 groups, there was a statistically significant difference (p<0.0001) that the wife's ASA value in the unexplained infertility group was significantly higher than that in the fertile group. This study concluded that the positive ASA results from the indirect MAR test were significantly found in the unexplained infertility sample.
Ratio of CD68/CD163 in Breast Carcinoma with and without Axillary Lymph Node Metastatic
Authors: Wiratama Priangga Adi , Sandhika Willy 
Published: May 2020

Tumor and its microenvironment can interact each other. Macrophage is part of tumor microenvironment. New drugs targeting specific superficial receptor of macrophage or cytokine of macrophage polarization have been found. Therefore, macrophage phenotype and its ratio of M1/M2 macrophage need to be identified. This identification could lead us to prognose breast cancer and monitor its therapy. Analytical observational study with cross sectional approach, conducted on paraffin block sample of breast carcinoma from Anatomical Pathology Laboratory of Dr. Soetomo General Hospital. The samples divided into four groups based on nodal metastasis staging (N0, N1, N2, and N3) and stained with antibody against CD68 and CD163. The ratio of CD68 and CD163 were analyzed with Anova test. There were difference expression of CD68 as M1 macrophage marker in various axillary node metastasis groups (p=0.015). There were difference ratio of CD68 as M1 macrophage marker and CD163 as M2 macrophage marker in various axillary node metastasis groups (p=0.005). There were difference ratio of macrophage M1 and macrophage M2 between N0 and N3 group, N2 and N3 group also.
DELINEASI SUB-CEKUNGAN SORONG BERDASARKAN ANOMALI GAYA BERAT
Authors: Zaenudin Ahmad , Dani Ilham , Amalia Niar 
Published: May 2020

Delineasi Sub-Cekungan Sorong ini diinterpretasi melalui pola anomali gayaberat, pola patahan, bukaan (rifting), tinggian dari anomali residual, dengan analisis Second Vertical Derivative (SVD), pemodelan 2D dan structural noses. Metode pengolahan data yang dilakukan dalam penelitian ini ialah melakukan koreksi gaya berat hingga didapatkan Anomali Bouguer Lengkap, melakukan analisis spektrum untuk mendapatkan estimasi kedalaman regional dan residual serta lebar jendela penapisan, melakukan pemisahan anomali regional dan residual dengan metode moving average, melakukan analisis SVD, melakukan interpretasi kualitatif dan kuantitatif. Hasil pengolahan menunjukkan bahwa pola Anomali Bouguer Lengkap daerah penelitian pada bagian Selatan didominasi oleh anomali rendah dengan nilai 58 hingga 76 mGal. Sedangkan anomali tinggi mendominasi bagian Utara dengan nilai 88 hingga 106 mGal. Kedalaman residual sekitar 2,7 km di bawah permukaan sedangkan kedalaman regional sekitar 10 km di bawah permukaan. Anomali residual daerah penelitian memiliki nilai anomali -9 hingga 10 mGal. Anomali regional daerah penelitian memiliki nilai anomali 60 hingga 100 mGal. Berdasarkan interpretasi kualitatif dan kuantitatif menunjukkan bahwa terdapat satu sub-cekungan pada daerah penelitian yang terletak pada Arar nose. Arah migrasi hidrokarbon berasal dari arah Barat ke Timur mengikuti struktur patahan. Berdasarkan penelitian ini, diasumsikan bahwa sesar utama Sorong tidak hanya berupa jenis sesar geser namun juga merupakan jenis sesar normal.
KARAKTERISTIK GEMPABUMI DI SESAR MATANO MENGGUNAKAN ANALISIS ENERGI KUMULATIF DAN PERIODE ULANG
Authors: Kurniawati Indah , Ratri Aldilla Damayanti Purnama , Gunawan Tomy 
Published: May 2020

Aktifitas seismik Sesar Matano sangat tinggi di mana gempabumi sering dirasakan masyarakat dan mengakibatkan kerusakan di area sekitarnya. Identifikasi aktifitas gempabumi dengan mengetahui besarnya energi yang dilepaskan di 6 segmen pada Sesar Matano diperlukan untuk perencanaan mitigasi gempabumi. Dilakukan juga estimasi periode ulang gempabumi yang akan terjadi disertai kemungkinan energi yang akan dilepaskan oleh gempabumi di masa yang akan datang. Data yang digunakan adalah katalog gempabumi EHB dan BMKG tahun 1961-2019. Energi gempabumi dihitung dengan mengkonversikan nilai momen seismik ke dalam energi fisis gempabumi. Sedangkan nilai momen seismik didapatkan dari konversi magnitudo gempabumi. Nilai periode ulang didapatkan dengan membagi nilai slip rata-rata terhadap sliprate. Berdasarkan hasil pengolahan data yang dilakukan di 6 segmen berbeda, yaitu Segmen Kuleana, Pewusai, Matano, Pamsoa, Ballawai, dan Garessa masing-masing memiliki nilai potensi magnitudo maksimum yang sedikit berbeda dengan magnitudo maksimum yang dikeluarkan PUSGEN. Semakin besar potensi magnitudo maksimumnya, maka semakin lama pula potensi gempa tersebut akan kembali berulang.
Early-stage clinical outcomes and rotational stability of TECNIS toric intraocular lens implantation in cataract cases with long axial length
Authors: He Suhong , Chen Xiang , Wu Xingdi , Ma Yajuan , Yu Xuewen , Xu Wen 
Published: May 2020

Abstract
Background: A major focus of toric intraocular lens (IOL) implantation is the rotational stability, especially in the patients with long axial length (AL). In this study, we aimed to evaluate the clinical outcomes after implantation of TECNIS toric IOL in eyes with long AL and identify factors influencing their early-stage stability with preoperative corneal astigmatism.Methods: The study population consisted of 64 eyes from 52 cataract patients, and these patients had preoperative corneal astigmatism between 1.0 and 3.7 diopters (D) and underwent phacoemulsification and TECNIS toric IOL implantation. Ophthalmic biological measurements were carried out preoperatively, including AL, anterior chamber depth (ACD), lens thickness (LT), vitreous length (VL), anterior chamber volume (ACV), sulcus-to-sulcus (STS) and keratometric value (K). Clinical examinations, including visual acuity, manifest refraction, keratometry, digital anterior segment photographs with pupillary dilation, were performed at 1 and 3 months after surgery. Results: The mean best corrected distance visual acuity (BCDVA) was improved from 0.93±0.35 logarithms of the minimal angle of resolution (logMAR) preoperatively to 0.07±0.10 logMAR postoperatively at 3 months after surgery. The mean residual astigmatism (RAS) was 0.91±0.74D at 3 months, which was significantly decreased compared with the preoperative corneal astigmatism of 1.71±0.55 D. The mean absolute rotation of TECNIS toric IOL at 1 and 3 months was 7.42±11.32 degree (°) (0-79°) and 7.48±11.19°(0-79°), respectively. The mean area of capsulorhexis and the overlapped area between capsulorhexis and optic intraoperatively was 21.04±3.30 mm2 and 7.40±2.87 mm2.A positive correlation was found between IOL rotation and the area of capsulorhexis (p=0.017) at 3 months after surgery. No correlation was found between IOL rotation and AL (p=0.876), ACD (p=0.387), LT (p=0.523), VL (p=0.546), ACV (p=0.480), STS (p=0.884), K1 (p=0.429)，K2 (p=0.644), average of K1 and K2 (p=0.520), intraoperative IOL axial direction (p=0.396), preoperative corneal astigmatism (p=0.269) or the overlapped area between capsulorhexis and optic intraoperatively (p=0.131) .Conclusions: The large CCC was a risk factor for toric IOL rotation. An appropriately smaller sized CCC was conducive to increase the rotational stability of TECNIS toric IOL implantation in cataract cases with long AL.
WITHDRAWN: Transconjunctival Cryo-Assisted Extraction of Intraconal Cavernous Hemangioma
Authors: ghafar ayman el sayed abd el sayed , Saleh Sameh M , Elwehidy Ahmed S , awara amr mahmoud 
Published: May 2020

Abstract
Background: The aim of this study is to evaluate the safety and efficacy of cryo-assisted transconjunctival orbitotomy for the extraction of intraconal cavernous hemangiomas.Methods: The study was performed at the Mansoura Ophthalmic Center, Mansoura University, Egypt from May 2017 to August 2018 and included 18 patients with orbital intraconal cavernous hemangiomas. In all the cases, preoperative orbital magnetic resonance imaging (MRI) with contrast was performed, the transconjunctival approach was used and cryo-assisted lesion extraction was performed. Cases were followed for six months after the surgery.Results: This study included 18 patients with intraconal cavernous hemangiomas, ten females (55.6%) and eight males (44.4%) with a mean age of 35.6 years. .The hemangiomas were lateral to the optic nerve in eight(44.5%), above the optic nerve in four cases(22.2%), and below the optic nerve in six cases(33.3%). Eight cases had postoperative complications: three cases (16.7%) had postoperative diplopia due to lateral rectus paresis that improved in all three cases within six months, one case (5.6%) had postoperative retrobulbar hemorrhage and proptosis that resolved within two weeks without sequelae, and four cases (22.2%) showed subconjunctival hemorrhages which resolved within two weeks. Of the two cases with preoperative decreases in visual acuity preoperative, one case (5.6%) showed improvement and one case (5.6%) did not improve. Conclusions: Cryoprobe-assisted transconjunctival orbitotomy for the excision of intraconal cavernous hemangiomas is a good approach with minor resolvable complications.Ethics approval : Mansoura institutional review board (IRB)Registration number: R/17.05.26Registration date: 10/5/2017Trial Registration:Name of registry: ISRCTN RegisterTrial registration number: ISRCTN45970569Retrospectively registered on 24/4/2020
Effect of grape seed proanthocyanidin extract in peripheral blood mononuclear cells of severe asthmatic patients
Authors: Sun Yun , Gu Bin , Qian Yan , Chen Yi , Mao Zheng-dao , Shi Yu-jia , Cao Qi , Wu Di , Zhang Qian 
Published: May 2020

Abstract
Backgroud To explore the Effect of grape seed proanthocyanidin extract（GSPE） in peripheral blood mononuclear cells of severe asthmatic patients. Methods 40 severe asthmatic patients were randomly and averagely divided into 2 groups: DXM group (n=20) and GSPE+DXM group (n=20), and 20 healthy volunteers as control gorup. Heparinized peripheral venous blood from each subject was collected in a sterile vacuum tube. The levels of interleukin (IL)-8 and monocyte chemotactic protein (MCP)-1 were detected by ELISA. The protein and mRNA expressions of Nuclear factor erythroid 2-related factor 2 (Nrf2), glutamatecysteine ligase modifier subunit (GCLM) inducible nitric oxide synthase (iNOS) and inactivation of histone deacetylase-2 (HDAC2) were detected by Western blot and qRT-PCR respectively. Glutathion(GSH) was measured by using Glutathione Fluorometric Detection Kit, and Nrf2-ARE binding ability was measured by using TransAM Nrf2 Transcription Factor ELISA Kit. Results The results showed that the levels of IL-8 and MCP-1 in normal control group were lower than those in severe asthma group (P <0.05). Treatment with GSPE+DXM reduced the levels of IL-8 and MCP-1 significantly when compared with DXM only ( P <0.05).The mRNA expression of iNOS in DXM group was significantly higher than that in control group. However, after adding GSPE treatment, the expression dramatically decreased ( P <0.001). On the contrary, lower mRNA expressions of Nrf2, GCLM and HDAC2 were found in DXM group than in control group ( P <0.001). Accordingly, when treated with GSPE, these expressions elevated and reached a statistical significance ( P <0.05). Consistently, the results from western blot analysis confirmed the role of GSPE on the protein expressions of iNOS, Nrf2, GCLM and HDAC2 in PBMCs of patients with severe asthma ( P <0.001). The PBMCs from patients with severe asthma exhibited lower Nrf2-ARE binding ability and produced less GSH than normal controls. GSPE treatment effectively augmented the Nrf2-ARE binding ability and the expression of GSH, which demonstrated the biological antioxidant potential of GSPE ( P <0.001). Conclusion GSPE can alleviate glucocorticoid resistance by regulating Nrf2-iNOS-HDAC2 signaling pathway in severe asthma, suggesting that GSPE have potential clinical application prospects in the treatment of severe asthma.