bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term biofouling formation mediated by extracellular proteins in Nannochloropsis gaditana microalga cultures at different medium N/P ratios
Authors: Soriano‐Jerez Y. , López‐Rosales L. , Cerón‐García M. C. , Sánchez‐Mirón A. , Gallardo‐Rodríguez J. J. , García‐Camacho F. , Molina‐Grima E. 
Published: November 2020

AbstractBiofouling represents an important limitation in photobioreactor cultures. The biofouling propensity of different materials (polystyrene, borosilicate glass, polymethyl methacrylate, and polyethylene terephthalate glycol‐modified) and coatings (two spray‐applied and nanoparticle‐based superhydrophobic coatings and a hydrogel‐based fouling release coating) was evaluated by means of a short‐term protein test, using bovine serum albumin (BSA) as a model protein, and by the long‐term culture of the marine microalga Nannochloropsis gaditana under practical conditions. The results from both methods were similar, confirming that the BSA test predicts microalgal biofouling on surfaces exposed to microalgae cultures whose cells secrete macromolecules, such as proteins, with a high capacity for forming a conditioning film before cell adhesion. The hydrogel‐based coating showed significantly reduced BSA and N. gaditana adhesion, whereas the other surfaces failed to control biofouling. Microalgal biofouling was associated with an increased concentration of sticky extracellular proteins at low N/P ratios (below 15).
Business model innovation: Identifying foundations and trajectories
Authors: Filser Matthias , Kraus Sascha , Breier Matthias , Nenova Ioanna , Puumalainen Kaisu 
Published: November 2020

AbstractBusiness model innovation is an emerging hot topic in management research. It has been developing steadily for 20 years and has gained enormous momentum in recent years. A solid basis has been created, and the first literature reviews summarize the topic. However, an analysis of the core literature and the general foundation of business model innovation literature is missing. This gap is closed with this bibliometric. It analyzes 30 core articles referenced in 380 business model innovation publications. From this, a total of four research clusters can be delineated. This foundation of the research area is supplemented with a trend analysis of recent publications, which identifies three trends for the future of this research stream. The analysis highlights that sustainability, dynamic capabilities, and small‐ and medium‐sized enterprises are the most promising trends in business model innovation. Based on the results, we present a general model for business model innovation.
Essential Oil Variation within Warburgia salutaris–A Coveted Ethnomedicinal Aromatic Tree
Authors: Leonard Carmen , Kamatou Guy , van Vuuren Sandy , Sandasi Maxleene , Viljoen Alvaro 
Published: November 2020

AbstractWarburgia salutaris, known as ‘Pepper bark’, is an ethnomedicinally important tree found in the southern regions of Africa. A total of 75 fresh leaf specimens of W. salutaris (n=40 wild and 35 cultivated) were collected from the Limpopo (wild) and KwaZulu‐Natal provinces (cultivated), two distinct locations in South Africa. In this study, the leaf essential oils obtained by hydrodistillation were characterized using gas chromatography coupled to mass spectrometry/flame ionization detection (GC/MS/FID). More than 15 compounds, accounting for 90–99 % of the total oil composition were identified. The analysis revealed that myrcene (0.6–65.3 %), (E)‐β‐ocimene (nd–56.9 %), (Z)‐β‐ocimene (nd–19.1 %), α‐pinene (nd–19.1 %) and limonene (nd–11.7 %) are major constituents of W. salutaris essential oils. Chemometric analysis revealed two major chemotypes within the essential oils with a modeled variation of approximately 60 %. Linalool and germacrene D were revealed as markers associated with the wild‐harvested oils, while cultivated oils were distinguished by higher levels of limonene and α‐humulene. The intra‐population variation indicated two chemically distinct chemotypes from three different populations, however, the season of harvest did not have a direct influence on the chemical profiles of the essential oils.
Prevalence and prognostic impact of hsCRP elevation are age‐dependent in women but not in men undergoing percutaneous coronary intervention
Authors: Blum Moritz , Cao Davide , Chandiramani Rishi , Goel Ridhima , Roumeliotis Anastasios , Sartori Samantha , Beyhoff Niklas , Kelle Sebastian , Kovacic Jason C , Krishnan Prakash , Sweeny Joseph , Barman Nitin , Baber Usman , Dangas George D. , Kini Annapoorna , Sharma Samin K. , Mehran Roxana 
Published: November 2020

AbstractBackgroundHigh‐sensitivity C‐reactive protein (hsCRP) predicts outcomes after percutaneous coronary intervention (PCI).ObjectiveWe studied the prevalence and prognostic impact of hsCRP elevation according to age in men and women undergoing PCI.MethodsWe included patients undergoing PCI at our center from 2010 until 2017, excluding those with myocardial infarction (MI) on presentation, neoplastic disease and hsCRP >10 mg/L at baseline. Elevated hsCRP was defined as >3 mg/L. The outcome of interest was major adverse cardiac events (MACE) consisting of all‐cause death, MI and target vessel revascularization. The association between hsCRP elevation and outcomes was assessed using adjusted Cox models.Results10,432 men and 4,345 women were included. Elevation of hsCRP was present in 25.7% of men and 37.0% of women (p < .01). In men, prevalence of hsCRP elevation was stable across age strata (ptrend = .42). In women, hsCRP elevation was most prevalent in patients <50 years (44.6%) and decreased stepwise with increasing age (ptrend < .001).After stratifying the population into age quartiles (Q1: <59 years, Q2: 59–66 years, Q3: 67–74 years, Q4: ≥75 years), hsCRP elevation was associated with increased risk of MACE across all age groups in men (HR [95% CI] Q1: 1.49 [1.12–1.98]; Q2: 1.51 [1.21–2.06]; Q3: 1.76 [1.27–2.51]; Q4: 1.43[1.03–1.97]). In women, hsCRP elevation was associated with increased risk of MACE only among older patients (HR [95% CI] Q1: 1.08 [0.64–0.82]; Q2: 1.52 [0.93–2.46]; Q3: 1.65 [1.08–2.50]; Q4: 1.52 [1.02–1.28]).ConclusionAmong patients undergoing PCI, prevalence and prognostic value of hsCRP elevation were age‐dependent exclusively in women.
Unusual clinical presentation of cutaneous leishmaniasis in a patient with corticosteroid‐induced immunosuppression
Authors: Mahdavi Maryam , Aryan Reihaneh , Nahidi Yalda , Teimoorian Mehrdad , Mashayekhi Vahid 
Published: November 2020

AbstractClinicians should always consider rare, atypical, and opportunistic infections in patients undergoing long‐term systemic corticosteroid therapy. Diagnosis needs further evaluations and special consideration.
Coronary sinus reducer transfemoral extraction after intraprocedural device migration: A case report
Authors: Bunc Matjaz , Sustersic Miha , Langel Crt , Kuhelj Dimitrij , Banai Shmuel 
Published: November 2020

AbstractThe coronary sinus reducer migration during implantation procedure is a rare complication with no standard bailout strategy. Transfemoral extraction of the reducer can be a safe and successful method, as demonstrated by this case report.
A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma
Authors: Correa Tatiana , Laux Douglas E. , Hoffman Henry T. 
Published: November 2020

AbstractPathogenic germline BRCA2 variants may be associated with an increased risk of hypopharyngeal squamous cell carcinoma that is more responsive to chemoradiation and chemotherapeutics targeting defective double‐strand DNA repair.
Death due to COVID‐19 in a patient with diabetes, epilepsy, and gout comorbidities
Authors: Safdarian Amir Reza , Momenzadeh Kaveh , Kahe Farima , Farhangnia Pooya , Rezaei Nima 
Published: November 2020

AbstractThere is evidence of increased incidence, rapid progression, and poor prognosis of COVID‐19 in patients with underlying comorbidities such as diabetes and epilepsy. Developing effective treatment regimens for COVID‐19 patients with multiple comorbidities is crucial, as patients' past medical history is an essential contributor to possible organ injuries in COVID‐19 patients. Herein, we report a confirmed case of COVID‐19 patient with a history of multiple underlying diseases, including diabetes, epilepsy, and gout. The patient developed multiple organ failure and died a week after intensive care unit (ICU) admission. Multiple organ failure is the most common cause of death in COVID‐19 patients.
Homochiral bifunctional L‐prolinamide‐ and L‐bis‐prolinamide‐catalyzed asymmetric aldol reactions performed in wet solvent‐free conditions
Authors: Huelgas Gabriela , Somanathan Ratnasamy , Hernández Pérez Julio M. , Rojas Cabrera Haydee , de la Higuera Macías Maximiliano , Domínguez‐Huerta Alejandra , Sabala Rocío , Anaya de Parrodi Cecilia 
Published: November 2020

AbstractIn this study, the novel bifunctional homochiral thiourea‐L‐prolinamides 1–4, tertiary amino‐L‐prolinamide 5, and bis‐L‐prolinamides 6 and 7 were prepared from enantiomerically pure (11R,12R)‐11,12‐diamino‐9,10‐dihydro‐9,10‐ethanoanthracene 8 and (11S,12S)‐11,12‐diamino‐9,10‐dihydro‐9,10‐ethanoanthracene ent‐8. Highly enantioselective and diastereoselective aldolic intermolecular reactions (up to 95% enantiomeric excess, 93:7 anti/syn) between aliphatic ketones (20 equiv) and a range of aromatic aldehydes (1 equiv) were successfully carried out in the presence of water (10 equiv) and monochloroacetic acid (10 mol%), solvent‐free conditions, at room temperature over 24 h using organocatalysts 1–7 (5 mol%). Stereoselective induction using density functional theory–based methods was consistent with the experimental data.
Ultrasonic Degradation of Polystyrene for Tailoring Molecular Weight and Polydispersity of Polystyrene Fragments
Authors: Zimmermann Jana , Kruppa David , Fischlschweiger Michael , Beuermann Sabine , Enders Sabine 
Published: November 2020

AbstractUltrasonic degradation of polymers attracts more and more attention in the field of chemical recycling of polymers due to the promising opportunity to tailor molecular weight and polydispersity of the gained polymer fragments. In this work, the influence of solvent, gas atmosphere, and ultrasound amplitude on the ultrasonic degradation process of polystyrene is investigated. Therefore, an experimental procedure to perform ultrasonic degradation of polystyrene under homogeneous temperature conditions in the solvents cyclohexane and toluene under the gas atmospheres CO2 and N2 for different ultrasonic amplitudes was designed. It could be shown that a significant effect on the molecular weight and polydispersity of the polymer could only be revealed for N2 and not for CO2 atmosphere.
Assisting students in their career choices: strategies for promoting students’ science identities following the science capital approach
Authors: Rüschenpöhler Lilith , Küsel Julian , Hönig Marina , Markic Silvija 
Published: November 2020

AbstractBerufsorientierung stellt ChemielehrerInnen vor eine besondere Herausforderung, da vor allem Mädchen und junge Frauen geringere naturwissenschaftliche Karriereaspirationen zeigen. Derzeit mangelt es an wissenschaftlich fundierten Ansätzen, eine naturwissenschaftliche Identitätsbildung in der Berufsorientierung im Unterricht bei Mädchen und jungen Frauen aktiv zu unterstützen. Die vorliegende Studie untersucht nach dem Science‐Capital‐Ansatz, welche Gesprächsstrategien in der Berufsorientierung die naturwissenschaftliche Identitätsbildung von Mädchen und jungen Frauen fördern können. Im Rahmen des DiSenSU‐Projekts zur Berufsorientierung in den Naturwissenschaften nahmen Mädchen und junge Frauen an einem Coachinggespräch über naturwissenschaftliche Identitäten und Karriereaspirationen teil. Für die vorliegende Studie wurden quantitative Daten zu Selbstkonzept und Karriereaspirationen sowie qualitative Daten aus den Coachinggesprächen analysiert. Untersucht wurde: (1) Welche Voraussetzungen bezüglich Selbstkonzept und Karriereaspirationen zeigen Mädchen und junge Frauen in der Reflexion über naturwissenschaftliche Berufe? (2) Welche Strategien der Gesprächsführung eignen sich, Science Capital zu fördern? Die Studie zeigt, wie Selbstkonzept und Karriereaspirationen als Anknüpfungspunkte im Coachinggespräch genutzt werden können und welche Gesprächsstrategien sich eignen, die naturwissenschaftliche Identitätsbildung bei Mädchen und jungen Frauen zu fördern.
A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent
Authors: de Souza Pereira Caroline , Costa Quadros Helenita , Magalhaes Moreira Diogo Rodrigo , Castro William , Santos De Deus Da Silva Romulo Ivisson , Botelho Pereira Soares Milena , Fontinha Diana , Prudêncio Miguel , Schmitz Vinicius , Dos Santos Hélio F. , Gendrot Mathieu , Fonta Isabelle , Mosnier Joel , Pradines Bruno , Navarro Maribel 
Published: November 2020

AbstractPlasmodium parasites kill 435 000 people around the world every year due to unavailable vaccines, a limited arsenal of antimalarial drugs, delayed treatment, and the reduced clinical effectiveness of current practices caused by drug resistance. Therefore, there is an urgent need to discover and develop new antiplasmodial candidates. In this work, we present a novel strategy to develop a multitarget metallic hybrid antimalarial agent with possible dual efficacy in both sexual and asexual erythrocytic stages. A hybrid of antimalarial drugs (chloroquine and primaquine) linked by gold(I) was synthesized and characterized by spectroscopic and analytical techniques. The CQPQ‐gold(I) hybrid molecule affects essential parasite targets, it inhibits β‐hematin formation and interacts moderately with the DNA minor groove. Its interaction with PfTrxR was also examined in computational modeling studies. The CQPQ‐gold(I) hybrid displayed an excellent in vitro antimalarial activity against the blood‐stage of Plasmodium falciparum and liver‐stage of Plasmodium berghei and efficacy in vivo against P. berghei, thereby demonstrating its multiple‐stage antiplasmodial activity. This metallic hybrid is a promising chemotherapeutic agent that could act in the treatment, prevention, and transmission of malaria.
Using NMR Spectroscopy in the Fragment‐Based Drug Discovery of Small‐Molecule Anticancer Targeted Therapies
Authors: Diethelm‐Varela Benjamin 
Published: November 2020

AbstractAgainst the challenge of providing personalized cancer care, the development of targeted therapies stands as a promising approach. The discovery of these agents can benefit from fragment‐based drug discovery (FBDD) methods that help guide ligand design and provide key structural information on the targets of interest. In particular, nuclear magnetic resonance spectroscopy is a promising biophysical tool in fragment discovery due to its detection capabilities and versatility. This review provides an overview of FBDD, describes the basis of NMR‐based fragment screening, summarizes some exciting technical advances reported over the past decades, and closes with a discussion of selected case studies where this technique has been used as part of drug discovery campaigns to produce lead compounds towards the design of anti‐cancer targeted therapies.
Extraction‐and‐excitation deep neural network for pansharpening
Authors: Lei Dajiang , Shen Ling , Zhang Liping , Li Weisheng 
Published: November 2020

AbstractWith the recent advances achieved by deep neural networks in image processing applications, researchers have begun exploring deep learning in pansharpening and obtained remarkable results. However, the existing methods are generally limited by their weak feature representation ability, often leading to spectral distortion or spatial blur. To generate high‐quality pansharpened images, this article proposes a novel neural network for pansharpening that includes both feature extraction and excitation mechanisms to consider important features. The neural network is modified with domain knowledge in pansharpening to fully extract spectral and spatial structures, and the proposed method outperforms traditional methods.
Influence of oncogenic mutations and tumor microenvironment alterations on extranodal invasion in diffuse large B‐cell lymphoma
Authors: Shen Rong , Xu Peng‐Peng , Wang Nan , Yi Hong‐Mei , Dong Lei , Fu Di , Huang Jin‐Yan , Huang Heng‐Ye , Janin Anne , Cheng Shu , Wang Li , Zhao Wei‐Li 
Published: November 2020

AbstractBackgroundDiffuse large B‐cell lymphoma (DLBCL) is an aggressive subtype of lymphoma, and multiple extranodal involvement (ENI) indicates adverse clinical outcomes. The aim of this study was to investigate the influence of oncogenic mutations and tumor microenvironment alterations on ENI in DLBCL.MethodsThe clinical features of 1960 patients with newly diagnosed DLBCL were analyzed, and DNA and RNA sequencing was performed on 670 and 349 patients, respectively. Oncogenic mutations and tumor microenvironment alterations were compared according to ENI and evaluated in zebrafish patient‐derived tumor xenograft models.ResultsMultiple ENI was significantly associated with poor performance status, advanced stage, elevated serum lactate dehydrogenase, low response rate, and inferior prognosis. Lymphoma invasion of the bones, spleen, bone marrow, liver, and central nervous system were independent unfavorable prognostic factors. MYD88 was frequently mutated in patients with multiple ENI, co‐occurred with mutations in CD79B, PIM1, TBL1XR1, BTG1, MPEG1, and PRDM1, and correlated with invasion of the bones, kidney/adrenal glands, breasts, testes, skin, and uterus/ovaries. For tumor microenvironment alterations, patients with multiple ENI showed higher regulatory T‐cell (Treg)‐recruiting activity, but lower extracellular matrix‐encoding gene expression, than those without ENI and with single ENI. Elevated Treg‐recruiting activity was related to mutations in B2M, SGK1, FOXO1, HIST1H1E, and ARID1A, and correlated with invasion of the bone marrow and thyroid. Additionally, mutations in MYD88, PIM1, TBL1XR1, SGK1, FOXO1, HIST1H1E, and ARID1A were associated with decreased major histocompatibility complex class I expression. Zebrafish models further revealed relationships between MYD88 mutations and invasion of the kidneys and gonads, as well as B2M mutations and invasion of the bone marrow. Increased CXCR4 expression is linked to bone marrow invasion in an organotropic way.ConclusionsOur findings thus contribute to an improved understanding of the biological behavior of multiple ENI and provide a clinical rationale for targeting ENI in DLBCL.
DNA metabarcoding provides insights into seasonal diet variations in Chinese mole shrew (Anourosorex squamipes) with potential implications for evaluating crop impacts
Authors: Tang Ke‐yi , Xie Fei , Liu Hong‐yi , Pu Ying‐ting , Chen Dan , Qin Bo‐xin , Fu Chang‐kun , Wang Qiong , Chen Shun‐de , Guo Ke‐ji 
Published: November 2020

AbstractDiet analysis of potential small mammals pest species is important for understanding feeding ecology and evaluating their impact on crops and stored foods. Chinese mole shrew (Anourosorex squamipes), distributed in Southwest China, has previously been reported as a farmland pest. Effective population management of this species requires a better understanding of its diet, which can be difficult to determine with high taxonomic resolution using conventional microhistological methods. In this study, we used two DNA metabarcoding assays to identify 38 animal species and 65 plant genera from shrew stomach contents, which suggest that A. squamipes is an omnivorous generalist. Earthworms are the most prevalent (>90%) and abundant (>80%) food items in the diverse diet of A. squamipes. Species of the Fabaceae (frequency of occurrence [FO]: 88%; such as peanuts) and Poaceae (FO: 71%; such as rice) families were the most common plant foods identified in the diet of A. squamipes. Additionally, we found a seasonal decrease in the diversity and abundance of invertebrate foods from spring and summer to winter. Chinese mole shrew has a diverse and flexible diet throughout the year to adapt to seasonal variations in food availability, contributing to its survival even when food resources are limited. This study provides a higher resolution identification of the diet of A. squamipes than has been previously described and is valuable for understanding shrew feeding ecology as well as evaluating possible species impacts on crops.
Thermal and nutritional environments during development exert different effects on adult reproductive success in Drosophila melanogaster
Authors: Min Kyeong Woon , Jang Taehwan , Lee Kwang Pum 
Published: November 2020

AbstractEnvironments experienced during development have long‐lasting consequences for adult performance and fitness. The “environmental matching” hypothesis predicts that individuals perform best when adult and developmental environments match whereas the “silver spoon” hypothesis expects that fitness is higher in individuals developed under favorable environments regardless of adult environments. Temperature and nutrition are the two most influential determinants of environmental quality, but it remains to be elucidated which of these hypotheses better explains the long‐term effects of thermal and nutritional histories on adult fitness traits. Here we compared how the temperature and nutrition of larval environment would affect adult survivorship and reproductive success in the fruit fly, Drosophila melanogaster. The aspect of nutrition focused on in this study was the dietary protein‐to‐carbohydrate (P:C) ratio. The impact of low developmental and adult temperature was to improve adult survivorship. High P:C diet had a negative effect on adult survivorship when ingested during the adult stage, but had a positive effect when ingested during development. No matter whether adult and developmental environments matched or not, females raised in warm and protein‐enriched environments produced more eggs than those raised in cool and protein‐limiting environments, suggesting the presence of a significant silver spoon effect of larval temperature and nutrition. The effect of larval temperature on adult egg production was weak but persisted across the early adult stage whereas that of larval nutrition was initially strong but diminished rapidly after day 5 posteclosion. Egg production after day 5 was strongly influenced by the P:C ratio of the adult diet, indicating that the diet contributing mainly to reproduction had shifted from larval to adult diet. Our results highlight the importance of thermal and nutritional histories in shaping organismal performance and fitness and also demonstrate how the silver spoon effects of these aspects of environmental histories differ fundamentally in their nature, strength, and persistence.
In vivo Electrochemical Monitoring of Signaling Transduction of Plant Defense Against Stress in Leaves of Aloe vera L.
Authors: Doménech‐Carbó Antonio , Dias Daiane , Donnici Margherita 
Published: November 2020

AbstractIn situ recording of the voltammetric response of Aloe vera L. leaves using graphite and platinum microelectrodes inserted in the subcuticular region is described. The plant response against the mechanical stress results in changes of the voltammetric signals associated to signal transduction compounds salicylic and jasmonic acids and hydrogen peroxide, which were separately monitored. A kinetic model is proposed to describe the time variation of the respective voltammetric signatures, denoting the possibility of in vivo electrochemical monitoring of biochemical processes in plants. The obtained results suggest that two defense pathways with different participation of ROS are operative.