bluuebunny/crossref_metadata_2025_split huggingface dataset:
T cell/Macrophage Dual-Targeting Biomimetic Triptolide Self-Assembly Nanodrugs For Rheumatoid Arthritis Therapy by Inflammatory Microenvironment Remodeling
Authors: Li Jing , Li Sanpeng , Li Chunbin , Li Hongfeng , Liu Chuangjun , zhao qi , Zhang Pengfei , Gong Ping , Cai Lintao 
Published: February 2020

Rheumatoid arthritis (RA) is an autoimmune disease causing severe joint damage, disability and decreased quality of life. Pathologically, numerous blood-derived cells infiltrating in synovium and cytokine secret necessitating formation of new blood vessels to generate pannus together form an inflammatory microenvironment. Triptolide with immunosuppressive activities is a potential drug to treat RA. However, it is still lack of an effective targeting system to deliver triptolide to RA site safely. Herein an inflammatory microenvironment targeting and remodeling nanoplatform is developed to achieve significantly effective RA treatment. In this system we synthesized a self-assembling triptolide nanoparticles (TPNs) mediated by dipeptide diphenylalanine which is the simplest self-assembly building block, then TPNs were entrapped by mannose-modified erythrocyte membranes to form engineering manRTPNs. For targeting, the immunological molecule of erythrocytes was firstly introduced to target T cells by ligand binding of LFA-3/LFA-2, and the coated mannose modified erythrocyte membrane also conferred the capacity of targeting to macrophages by mannose and its receptor CD206; for remodeling inflammatory microenvironment, TPNs could selectively exert its suppressive effects on different cells of RA including lymphocytes and synovial fibroblasts. In collageninduced arthritis mice, manRTPNs showed excellent targeting effect and prolonged accumulation at inflamed joint. After manRTPNs treatment, swollen paws of CIA considerably shrunk to normal, boss loss even recovered healthy level and cartilage preserved at synovium cavity, because of systemically conventional cytokine reduction and expression shift of core genes in networks of RA microenvironment. Therefore, this well-defined manRTPNs might be a well promising systematic therapeutic agent for RA.
THÀNH PHẦN LOÀI, ĐẶC ĐIỂM PHÂN BỐ DA GAI (ECHINODERMATA) VÀ THÂN MỀM (MOLLUSCA) Ở VỊNH XUÂN ĐÀI, TỈNH PHÚ YÊN
Authors: Trung Hoàng Đình 
Published: February 2020

Bài báo công bố kết quả điều tra tổng hợp về thành phần loài động vật Da gai và Thân mềm ở vịnh Xuân Đài, tỉnh Phú Yên trong hai năm 2017 -2018. Cho đến nay đã xác định được 93 loài thuộc 05 lớp, 18 bộ, 38 họ, 59 giống và 02 ngành (Da gai - Echinodermata và Thân mềm - Mollusca). Trong đó, ngành Thân mềm (Mollusca) chiếm ưu thế nhất với 74 loài thuộc 2 lớp (Chân bụng và Hai mảnh vỏ), 12 bộ, 26 họ, 44 giống; ngành Da gai (Echinodermata) có 19 loài thuộc 3 lớp (Sao biển, Hải sâm, Cầu gai), 6 bộ, 12 họ, 14 giống. Nghiên cứu đã bổ sung mới cho thành phần loài Da gai và Thân mềm của vịnh Xuân Đài, tỉnh Phú Yên gồm 26 loài, 11 giống, 13 họ. Đặc điểm phân bố theo không gian cho thấy tại Vũng Chùa có số loài chiếm ưu thế nhất với 68 loài (chiếm 73,12%), tiếp đến là Vũng La có 65 loài (chiếm 69,89%), phường Xuân Yên có 61 loài (chiếm 65,59%), phường Xuân Đài có 53 loài (chiếm 56,99%), phường Xuân Thành có 51 loài (chiếm 54,84%), xã Xuân Phương và phường Xuân Phú cùng có 47 loài (chiếm 50,54% ) và Vũng Chào chỉ có 44 loài (chiếm 47,31%). Có 6 loài được ghi nhận trong Danh mục Sách Đỏ Việt Nam (2007) và Quyết định 82/2008 của Bộ Nông nghiệp và Phát triển Nông thôn.
Etika Kedokteran dalam Kegiatan Tanggap Darurat Bencana
Authors: Sjamsuhidajat R , Meilia Putri Dianita Ika , Zulfiyah Itsna Arifatuz 
Published: February 2020

Bencana dapat menghancurkan satu negara dalam waktu singkat, baik karena kerusakan struktur maupun wabah penyakit yang diakibatkan setelahnya. Indonesia merupakan salah satu negara yang paling rentan terhadap bencana, baik bencana yang disebabkan oleh faktor alam maupun faktor manusia. Untuk mencegah dan mengurangi kerusakan yang disebabkan oleh bencana, Indonesia membutuhkan sistem penanggulangan bencana yang kokoh. Berbagai dilema etik sering kali muncul dalam penanggulangan bencana ini. Beberapa dilema etik yang paling menonjol di Indonesia antara lain dilema dalam triase, melakukan riset, meminta informed consent, memberikan pelayanan dalam sarana yang terbatas, serta melindungi keselamatan dan kesehatan tenaga medis yang membantu korban bencana sesuai Konvensi Jenewa.
Pembinaan Kelompok Tani Untuk Optimalisasi Lahan Sempit Berbasis Konservasi Tanah
Authors: Masnang Andi , Andriyanty Reny , Hendri Aisyah , Djannah Asmanur 
Published: February 2020

Abstract. The Farmer group encouraging for incapacious land optimalization base on soil conservation aim to enhance the farmer capability in conservation agriculture, farmer’s ability, and land use optimalization. The expectation of this activity is the decreasing of farmer’s income and welfare. The method is counseling and plot demonstration. The procedure of this activity consist of three main stages. First stage is agricultural extension, second stage is the training of media-plant making, and third stage is farmer training on plantation plot demonstration. The outcome of the activities shown that: (10) 100 percent of participant farmers declare that their technically and economic knowledge increase, (2) Their opinion are easy, inexpensive, applicative and base on local resource which the paralon can be replaced by bamboo. It is also applicative because the farmer can adjust the plantation. The farmers are directed to plant high-economic value and unstable price such as chilli, and (3) 60 percents farmers are pleased and 40 percents farmers are very satisfied. The farmers who members of farmer group wish that this ectivity can be held regularly.Abstrak. Pembinaan pada kelompok petani untuk optimalisasi lahan untuk kegiatan pertanian berbasis konservasi tanah guna revitalisasi pekarangan lahan sempit melalui bioteknologi vertikultur ini bertujuan untuk meningkatkan kemampuan petani dibidang teknologi budidaya berbasis konservasi lahan, kompetensi petani, optimalisasi penggunaan lahan. Diharapkan setelah kegiatan ini terjadi peningkatan pendapatan dan kesejahteraan petani dan buruh tani. Metode program ini adalah melakukan penyuluhan dan pelatihan demplot. Prosedur kerja kegiatan ini terdiri atas tiga tahapan utama, tahap pertama merupakan penyuluhan penggunaan Lahan Berbasis Konservasi Tanah, tahap kedua berupa pelatihan pembuatan media dan tahap ketiga adalah pelatihan petani di demplot penanaman. Hasil kegiatan ini menunjukkan bahwa : (1) 100 persen petani peserta kegiatan ini menyatakan bahwa pengetahuan teknik dan ekonomi semakin meningkat, (2) bioteknologi vertikultur ini sangat mudah, murah, aplikatif dan berbasis sumberdaya lokal karena metode yang mudah, bahannya murah dan berbasis sumberdaya lokal dimana pipa paralon dapat digantikan dengan bambu. Aplikatif karena dapat disesuaikan jenis tanamannya. Petani juga diarahkan untuk menanam tanaman kebutuhan pokok, bernilai ekonomi tinggi yang harganya cenderung tidak stabil seperti cabai, dan (3) 60 persen petani peserta merasa puas dan 40 persennya sangat puas. Anggota kelompok tani ini juga mengingkan diadakan pertemuan rutin yang dapat membimbing mereka dalam berusahatani.
Pemberdayaan Pembudidaya Kerapu Melalui Aplikasi Automatic Fish Feeder Untuk Efisiensi Pakan Di Tambak Budidaya Semi Intensif
Authors: Arsad Sulastri 
Published: February 2020

Abstract. Empowerment program for grouper fish farmers in Labuhan Village, Labuhan Subdistrict, Lamongan Regency, aimed to share knowledge, increase partner understanding and skills on semi-intensive aquaculture ponds, monitor water quality parameters through water quality measurement training, and process grouper fish aquaculture using appropriate technology by introducing automatic feeder devices independently. This community service activity has been carried out in the Bhakti Usaha II Farmer Group in Labuhan Village, Lamongan Regency, targeting grouper fish farmer partner. This activity started from Mei to November 2018. The program consists of location survey, discussion and training about water quality measurement, as well as socialization and testing of automatic feeder machine, and monitoring and evaluation at the end. The discussion material presented includes criteria for grouper fish farming, feed management, and automatic feeder use. An auto feeder application in ponds is used for feeding efficiency and so that the feed given is absorbed by fish effectively. This is expected to reduce the cost of feed and farm power efficiency and increase production of cultivation crops and partner income. Overall, the empowerment program has reached 100% of activities, which the positive feedback from grouper fish partner is determined by questionnaire analysis. Abstrak. Pemberdayaan pada kelompok pembudidaya ikan kerapu di Desa Labuhan Kecamatan Labuhan Kabupaten Lamongan bertujuan untuk berbagi pengetahuan, peningkatan pemahaman dan keterampilan mitra dalam peningkatan teknologi semi intensif di tambak budidaya ikan kerapu, pemantauan kualitas air melalui pelatihan pengukuran kualitas air, dan proses budidaya ikan kerapu melalui pemanfaatan teknologi tepat guna dengan pengenalan alat automatic feeder secara mandiri. Kegiatan pengabdian kepada masyarakat ini dilaksanakan pada Kelompok Petani Tambak Bhakti Usaha II yang berada di Desa Labuhan Kabupaten Lamongan dengan menyasar 1 mitra yang merupakan pembudidaya ikan kerapu. Kegiatan DM ini dimulai pada Bulan Mei sampai November 2018. Kegiatan yang dilaksanakan yaitu survei lokasi budidaya, penyuluhan dan pelatihan pengukuran kualitas air, sosialisasi dan uji coba mesin automatic feeder, serta monitoring dan evaluasi kegiatan. Materi penyuluhan yang disampaikan meliputi kriteria budidaya ikan kerapu, manajemen pakan, dan penggunaan automatic feeder. Aplikasi autofeeder di tambak digunakan untuk efisiensi pemberian pakan dan agar pakan yang diberikan terserap oleh ikan secara efektif. Hal ini diharapkan dapat mengurangi cost pakan dan efisiensi tenaga tambak serta meningkatkan produksi hasil panen budidaya dan pendapatan mitra. Pelaksanaan kegiatan telah mencapai 100% dan memperoleh feed back positif dari masyarakat pembudidaya melalui kuesioner yang diberikan.
Patterns of Consumption in Renaissance Venice
Authors: Cecchini Isabella 
Published: February 2020

Reconstructing prices and price indexes for pre-industrial societies is always a challenge for researchers. Despite the fact that several account books have been preserved and may offer purchase and sale prices of a wide range of goods, the definition of a consumer basket – a set of different quantities of goods forming the basic consumption unit for an average individual or family – faces several difficulties. Average consumption is difficult to establish even in pre-industrial times, since buying activities vary of course not only according to wealth and income, but also to social class; and it is usually difficult to record and weigh self-consumption. It seems more important to offer some parameters from a single case study, the ledger of a Venetian patrician recording his purchases on a daily basis, in a couple of months in 1455.
Jumping the digital divide: How do “silver surfers” and “digital immigrants” use social media?
Authors: Fietkiewicz Kaja 
Published: February 2020

For a long time, a digital divide was given between young Web users and older population, which out of anxiety or incapability restrained from using the new technologies. Recently, the so-called “Silver Surfers” and “Digital Immigrants” tend to use the Web not only for sending emails but also increasingly for socializing on social media services (e.g., Kübler 2009; Frees & Koch 2015). This paper aims to discuss the differences in use and adoption of social media platforms between different generations. An online questionnaire was created and distributed among social media users of all ages. The results indicate that the older generations represented a not insignificant part of social media community. They often use Facebook to keep in touch with friends and family, some apply Twitter and are fond of new followers and many re-tweets, and others just enjoy new videos on YouTube. There indeed appear to exist inter-generational differences in social media usage. In addition, data analysis leads to the conclusion that there are intra-generational gender-dependent particularities as well.
Position-in-frame
Authors: Moore Cath 
Published: February 2020

An integral connection point between the screenplay and reader/viewer is the protagonist’s transformative journey. The construction of this narrative backbone is critical to the articulation of overarching thematic concerns and story premise but also reflects the story creator’s worldview- one often coloured by representations of gender. The Hollywood model certainly divides narrative function along gender lines but does this representation hold true within a different cultural context? This article examines the selected screen stories of Danish director Susanne Bier whose partnership with screenwriter Anders Thomas Jensen is one of Denmark’s most successful film partnerships. Employing a case study methodology I examine the dramatic function of and agency afforded screen characters and the critical dynamic between cultural landscape, practitioner preference and narrative inquiry. Key to this address is an exploration of mobility, legacy and sacrifice as textual considerations of gender and its utilisation as transnational narrative strategy.
Introduction
Authors: Castaldo Lunden Elizabeth 
Published: February 2020

This special issue belongs to a series of activities under the umbrella denomination “Studying and Exploring the Intersections of Fashion, Film, and Media Studies,” created in 2014 by film scholar Anne Bachmann and I. Our goal was to promote an interdisciplinary perspective to the study of fashion, film, and media. This venture was launched with two activities at the 2015 edition of the annual conference of the Society for Cinema and Media Studies, in Montreal. The first activity consisted of a panel featuring the on-going projects of four Ph.D. students working with these combined fields.[1] The second activity consisted of a workshop, in which presentations opened to discussions addressing how the use of archival material and film fan magazines, combined with film studies’ methodological approach to history, could benefit fashion research.[2] This workshop expanded into a Symposium at Stockholm University featuring established scholars who pioneered research in these fields of studies combined. This special issue of Networking Knowledge seeks to include early career researchers in such conversation, broadening the network of scholars and the combined field of expertise. Since its inception, a historical approach has been encouraged by the founders of this project. Yet, the semiotic roots used for textual analysis of costume design shall not be overlooked. In this sense, this special issue intends to present a panorama of the heterogeneous nature of studies in these interconnected fields.

[1] The panel was titled “Industry Crossovers: Key Women in Fashion, Film, and Media,” with Michelle Tolini Finamore as respondent, SCMS Conference, Montreal.
[2] The workshop featured presentations by Tamar Jeffers McDonald, Jenny Romero, and Elizabeth Castaldo Lundén. Because Fashion Matters: Studying the Intersections of Fashion, Film, and Media, SCMS Conference, Montreal, 29th March 2015.
Identification of Superficial White Matter Abnormalities in Alzheimer’s Disease and Mild Cognitive Impairment Using Diffusion Tensor Imaging
Authors: Bigham Bahare , Zamanpour Seyed Amir , Zemorshidi Fariba , Boroumand Farzaneh , Zare Hoda ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: February 2020

Background: Diffusion tensor imaging (DTI) estimates the microstructural alterations of the brain, as a magnetic resonance imaging (MRI)-based neuroimaging technique. Prior DTI studies reported decreased structural integrity of the superficial white matter (SWM) in the brain diseases. Objective: This study aimed to determine the diffusion characteristics of SWM in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) using tractography and region of interest (ROI) approaches. Methods: The diffusion MRI data were downloaded from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database on 24 patients with AD, 24 with MCI, and 24 normal control (NC) subjects. DTI processing was performed using DSI Studio software. First, for ROI-based analysis, The superficial white matter was divided into right and left frontal, parietal, temporal, insula, limbic and occipital regions by the Talairach Atlas, Then, for tractography-based analysis, the tractography of each of these regions was performed with 100000 seeds. Finally, the average diffusion values were extracted from voxels within the ROIs and tracts. Results: Both tractography and ROI analyses showed a significant difference in radial, axial and mean diffusivity values between the three groups ( p < 0.05) across most of the SWM. Furthermore, The Mini-Mental State Examination was significantly correlated with radial, axial, and mean diffusivity values in parietal and temporal lobes SWM in the AD group ( p < 0.05). Conclusion: DTI provided information indicating microstructural changes in the SWM of patients with AD and MCI. Therefore, assessment of the SWM using DTI may be helpful for the clinical diagnosis of patients with AD and MCI.
Olive oil varieties cultivated in Morocco reduce reactive oxygen species and cell viability of human cervical cancer cells
Authors: El Hilali Hajar , El Hilali Fatiha , Porter Sarah E. G. , Ghali Sarah A. , Meyls Hannah M. , Ouazzani Noureddine , Laziri Fatiha , Barber Amorette 
Published: February 2020

BACKGROUND: The Moroccan diet incorporates olive oil as the primary source of fat and may reduce cancer risk. However, different olive oil varieties often have varying levels of anti-cancer polyphenols and thus have unique biologic effects. OBJECTIVE: The anti-cancer activity of five varieties of extra virgin Moroccan-cultivated olive oil on human cervical cancer cells was assessed in vitro. METHODS: The presence of phenolic compounds in five olive oil varieties cultivated in Morocco was analyzed using HPLC. Human cervical cancer cell lines (HeLa, SKG-II, and HCS-2) were incubated with the olive oils and cell viability was measured by MTT assay, reactive oxygen species were measured using the CellRox assay, and gene expression was measured by RT-PCR. RESULTS: Each of the five Moroccan-cultivated olive oil varieties had a unique composition of phenolic compounds. Incubation with the olive oils reduced cell viability and reactive oxygen species in human cervical cancer cells. The expression of genes involved in cervical cancer carcinogenesis and cell cycle were also altered. All five olive oil varieties decreased expression of E6, E7, p16, p63, and NRP2 and increased expression of IVL and miR 331-3p. CONCLUSIONS: Use of Moroccan-cultivated olive oils could be a promising anti-cancer agent for cervical cancer.
Deep text classification of Instagram data using word embeddings and weak supervision
Authors: Hammar Kim , Jaradat Shatha , Dokoohaki Nima , Matskin Mihhail 
Published: February 2020

With the advent of social media, our online feeds increasingly consist of short, informal, and unstructured text. Instagram is one of the largest social media platforms, containing both text and images. However, most of the prior research on text processing in social media is focused on analyzing Twitter data, and little attention has been paid to text mining of Instagram data. Moreover, many text mining methods rely on training data annotated manually by humans, which in practice is both difficult and expensive to obtain. In this paper, we present methods for weakly supervised text classification of Instagram text. We analyze a corpora of Instagram posts from the fashion domain and train a deep clothing classifier with weak supervision to classify Instagram posts based on the associated text. With our experiments, we demonstrate that in absence of annotated training data, using weak supervision to train models is a viable approach. With weak supervision we were able to label a large dataset in hours, something that would have taken months to do with human annotators. Using the dataset labeled with weak supervision in combination with generative modeling, an [Formula: see text] score of 0.61 is achieved on the task of classifying the image contents of Instagram posts based solely on the associated text, which is on level with human performance.
Radiomics analysis of multicenter CT images for discriminating mucinous adenocarcinoma from nomucinous adenocarcinoma in rectal cancer and comparison with conventional CT values
Authors: Ge Yu-xi , Li Jie , Zhang Jun-qin , Duan Shao-feng , Liu Yan-kui , Hu Shu-dong 
Published: February 2020

OBJECTIVE: To investigate the value of CT-based radiomics signature for preoperatively discriminating mucinous adenocarcinoma (MA) from nomucinous adenocarcinoma (NMA) in rectal cancer and compare with conventional CT values. METHOD: A total of 225 patients with histologically confirmed MA or NMA of rectal cancer were retrospectively enrolled. Radiomics features were computed from the entire tumor volume segmented from the post-contrast phase CT images. The maximum relevance and minimum redundancy (mRMR) and LASSO regression model were performed to select the best preforming features and build the radiomics models using a training cohort of 155 cases. Then, predictive performance of the models was validated using a validation cohort of 70 cases and receiver operating characteristics (ROC) analysis method. Meanwhile, CT values in post- and pre-contrast phase, as well as their difference (D-values) of tumors in two cohorts were measured by two radiologists. ROC curves were also calculated to assess diagnostic efficacies. RESULTS: One hundred and sixty-three patients were confirmed by pathology as NMA and 62 cases were MA. The radiomics signature comprised 19 selected features and showed good discrimination performance in both the training and validation cohorts. The areas under ROC curves (AUC) are 0.93 (95% confidence interval [CI]: 0.89–0.98) in training cohort and 0.93 (95% CI: 0.87–0.99) in validation cohort, respectively. Three sets of CT values of MA in pre- and post-contrast phase, and their difference (D-value) (31±7.0, 51±12.6 and 20±9.3, respectively) were lower than those of NMA (37±5.6, 69±13.3 and 32±11.7, respectively). Comparing to the radiomics signature, using three sets of conventional CT values yielded relatively low diagnostic performance with AUC of 0.84 (95% CI: 0.78–0.88), 0.75 (95% CI: 0.69–0.81) and 0.78 (95% CI: 0.72–0.83), respectively. CONCLUSION: This study demonstrated that CT radiomics features could be utilized as a noninvasive biomarker to identify MA patients from NMA of rectal cancer preoperatively, which is more accurate than using the conventional CT values.