bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell-type-specific promoters forC. elegansglia
Authors: Fung Wendy , Wexler Leigh , Heiman Maxwell G. 
Published: June 2020

ABSTRACTGlia shape the development and function of theC. elegansnervous system, especially its sense organs and central neuropil (nerve ring). Cell-type-specific promoters allow investigators to label or manipulate individual glial cell types, and therefore provide a key tool for deciphering glial function. In this technical resource, we compare the specificity, brightness, and consistency of cell-type-specific promoters forC. elegansglia. We identify a set of promoters for the study of seven glial cell types (F16F9.3, amphid and phasmid sheath glia;F11C7.2, amphid sheath glia only;grl-2, amphid and phasmid socket glia;hlh-17, cephalic (CEP) sheath glia; andgrl-18, inner labial (IL) socket glia) as well as a pan-glial promoter (mir-228). We compare these promoters to promoters that are expressed more variably in combinations of glial cell types (delm-1anditx-1). We note that the expression of some promoters depends on external conditions or the internal state of the organism, such as developmental stage, suggesting glial plasticity. Finally, we demonstrate an approach for prospectively identifying cell-type-specific glial promoters using existing single-cell sequencing data, and we use this approach to identify two novel promoters specific to IL socket glia (col-53andcol-177).
High titer methyl ketone production with tailoredPseudomonas taiwanensisVLB120
Authors: Nies Salome C. , Alter Tobias B. , Nölting Sophia , Thiery Susanne , Phan An N. T. , Drummen Noud , Keasling Jay D. , Blank Lars M. , Ebert Birgitta E. 
Published: June 2020

AbstractMethyl ketones present a group of highly reduced platform chemicals industrially produced from petroleum-derived hydrocarbons. They find applications in the fragrance, flavor, pharmacological, and agrochemical industries, and are further discussed as biodiesel blends. In recent years, intense research has been carried out to achieve sustainable production of these molecules by re-arranging the fatty acid metabolism of various microbes. One challenge in the development of a highly productive microbe is the high demand for reducing power. Here, we engineeredPseudomonas taiwanensisVLB120 for methyl ketone production as this microbe has been shown to sustain exceptionally high NAD(P)H regeneration rates. The implementation of published strategies resulted in 2.1 g Laq-1methyl ketones in fed-batch fermentation. We further increased the production by eliminating competing reactions suggested by metabolic analyses. These efforts resulted in the production of 9.8 g Laq-1methyl ketones (corresponding to 69.3 g Lorg-1in thein situextraction phase) at 53 % of the maximum theoretical yield. This represents a 4-fold improvement in product titer compared to the initial production strain and the highest titer of recombinantly produced methyl ketones reported to date. Accordingly, this study underlines the high potential ofP. taiwanensisVLB120 to produce methyl ketones and emphasizes model-driven metabolic engineering to rationalize and accelerate strain optimization efforts.
Hand Washing Compliance and COVID-19: A Non-Participatory Observational Study among Hospital Visitors
Authors: Sahiledengle Biniyam , Tekalegn Yohannes , Takele Abulie , Zenbaba Demisu , Teferu Zinash , Tasew Alelign , Assefa Tesfaye , Bekele Kebebe , Tesemma Abdi , Gezahegn Habtamu , Awoke Tadesse , Quisido Bruce John Edward 
Published: June 2020

AbstractBackgroundHand washing remains a key measure for intercepting the dispatch of the Coronavirus disease (COVID-19). However, hand washing must be perpetuated properly using soap and water for at least 20 seconds. In response to the current COVID-19 pandemic, various hospitals have imposed mandatory hand washing to everyone prior entering the facilities, and when leaving. This study aimed to assess the hand washing compliance among visitors of a university referral hospital.MethodsA non-participatory observational study was conducted in the main entrance of the hospital from April 27 to May 3, 2020, to measure hand washing compliance of its visitors. The quality of hand washing was assessed via direct observation for compliance with the recommended World Health Organization (WHO) core steps. Data were collected using Open Data Kit (ODK) mobile application.ResultsA total of 1,282 hospital visitors were observed, of which 874(68.2%) were males. Full hand washing compliances were observed among 0.9% (95% CI: 0.4–1.4) of the visitors. Withal, there was no difference in the compliances between genders (0.9% vs 0.7%, P = 0.745).ConclusionDespite the fact that proper hand washing with soap and water is proven to be one of the effective ways in preventing the spread of COVID-19, a significant number of hospital visitors did not practice standard hand washing procedures. Improvements in this measure are urgently needed in the face of the current COVID-19 pandemic.
Critical success factors for digital partnering of construction organisations – a Delphi study
Authors: Aghimien Douglas Omoregie , Aigbavboa Clinton Ohis , Oke Ayodeji Emmanuel 
Published: June 2020

PurposeThe construction organisations in developing countries are lagging in digital technology usage; hence, they are still characterised by poor project delivery and technological backwardness. To checkmate this problem, partnering with other organisations was proposed, while critical factors needed for successful digital partnering of construction organisations were assessed.Design/methodology/approachThe study adopted a qualitative research approach. Delphi method was used to get experts' opinion on some identified factors necessary for successful digital partnering. The experts for the study were selected using defined criteria, and a combination of interquartile deviation, Kendall's coefficient of concordance and chi-square was used to achieve robust consensus among respondents. Mann–Whitney U test was also used to ascertain the difference in perception of experts.FindingsThe findings revealed trust in digital partners, top management support and digital partner selection as the three key success factors for partnering. Other factors that can be considered alongside these main factors are the creation of a common goal, a long-term commitment, effective communication, proper conflict resolution and structured as well as continuous digital training, workshops and meetings.Practical implicationsInstead of going through the digitalisation journey alone, construction organisations, particularly in a developing country like South Africa, stand a better chance of surviving the dynamic construction and digital environment by partnering with other organisations within and outside the industry. Carefully selecting the right partner, trusting in their capability and ensuring constant commitment is necessary for the success of the process.Originality/valueThe value of this study lies in its ability to showcase the critical success factors needed for effective digital partnering, an aspect that lacks adequate consideration in the digitalisation of construction industry discourse.
Taking measure: the link between metrics and marketing’s exploitative and explorative capabilities
Authors: Nath Pravin 
Published: June 2020

PurposeWhile metrics are becoming increasingly important for marketing’s relevance, there is also a need to understand how they, as enablers of learning, affect marketing’s adaptive capabilities that ensure its long-term success. Therefore, this study aims to test the association of marketing and financial metrics use and the metric-based orientations of training and compensation, with two key marketing routines – exploitation, i.e. the perfecting of existing activities while allowing for incremental adaptations and exploration or experimentation accompanied by radical adaptation.Design/methodology/approachThe study gathers data from 205 managers and uses partial least squares structural equation modeling to test the hypothesized relationships.FindingsMarketing metrics encourage both forms of marketing adaptation. Financial metrics use discourages exploration. Market orientation and long-term orientation strengthen (weaken) the positive (negative) relationship between marketing (financial) metrics use and marketing exploration. Metric-based training is more positively associated with both adaptive capabilities than a metric-based compensation orientation, albeit weakly.Research limitations/implicationsThe study’s central proposition – that different metrics or metric orientations are associated with distinct types of knowledge, interpretations, mindsets, motivations and cultural contexts – provides a deeper theoretical understanding of the pathways by which a metric emphasis affects marketing adaptation.Practical implicationsMarketing managers should emphasize marketing metrics and training more than compensation, to promote marketing exploitation/exploration, while exercising caution in overstressing financial metrics given their negative association with exploration. This latter negative relationship can be weakened (as can the positive one between marketing metrics and exploration be strengthened) with increased market orientation and long-term orientation.Originality/valueThis study addresses the research gap regarding the relationship between metrics as a configurational element of marketing organization and marketing adaptation.
Performance management systems in Lebanese private higher education institutions: design and implementation challenges
Authors: Al Jardali Hussein , Khaddage-Soboh Nada , Abbas Mohammad , Al Mawed Nour 
Published: June 2020

PurposeThe purpose of this study is at creating a performance management system template based on the Balanced Scorecard (BSC) framework, which could lead the scorecard to function properly at Arts, Sciences and Technology University in Lebanon (AUL) and, as assumed, in other Lebanese private higher educational institutions.Design/methodology/approachThis study compares existing theoretical models applied in private higher education institutions (HEIs) in Lebanon. It adopts inductive approach with semi-structured interviews that helped the authors understand the way BSC is implemented in the private Lebanese institutions.FindingsThis study suggested a customizable BSC to be used at AUL and other Lebanese private HEIs to enhance and calibrate their organizational performance.Originality/valueMany researchers have investigated the use of Robert Kaplan and David Norton's BSC in various types of organizations, but there was no specific study describing the Lebanese higher education system. This study investigates the use of the BSC framework in Lebanese private HEIs taking Arts, Science and Technology University in Lebanon (AUL) as a sample. Moreover, this study also adapted a BSC model to the case of a private HEI, which extends the current body of literature related to the use, implementation and adaptation of the BSC.
Numerical investigation of conjugate heat transfer and entropy generation of MHD natural convection of nanofluid in an inclined enclosure
Authors: Kardgar Amin 
Published: June 2020

Purpose
The purpose of this paper is to investigate conjugate heat transfer of natural convection and entropy generation of nanofluid in the presence of external magnetic field via numerical approach in an inclined square cavity enclosure.

Design/methodology/approach
Control volume finite volume method with collocated arrangement of grids was used for discretization of continuity, momentum, solid and fluid energy equations. Rhie and Chow interpolation technique was applied to avoid checkerboard problem in pressure field and the well-established SIMPLE algorithm was followed to deal with the pressure and velocity coupling. The cavity is filled with water and nanoparticles of the aluminum oxide (Al2O3). This study has been conducted for the certain pertinent parameters of the volume fraction of nanoparticle (φ = 0–0.08), the angle of inclination (ϴ = 0°–330°), the Ra number (Ra = 103–108), the solid to fluid conductivity ratio (ksf = 1–400), the Ha number (Ha = 0–80) and the wall thickness ratio (δ/L = 0–0.3).

Findings
The results indicate that averaged Nu number increases by approximately 9% by increasing volume fraction from 0.0 to 0.08. Nu increases with an increasing inclination angle to 40° and decreases abruptly in 90° because of the formation of two weaker vorticity with opposite circulation pattern intensifying the density of isotherm curves in a vertical direction. Nu increases sharply with increasing Ra more than 105. Nu also augments almost 67% by increasing ksf = 1 to ksf = 50 and remains constant by increasing ksf more than 50. Nu number reduction is almost 72% with a variation of wall thickness ratio from d/L = 0 to 0.3. Entropy generation because of fluid flow, magnetic field and heat transfer reduces linearly almost 30%, 19% and 16% by increasing volume fraction, respectively. With increasing ksf, entropy generation because of fluid flow, magnetic field and heat transfer increases asymptotically, but Bejan number decreases.

Originality/value
A brief review of conducted research studies in nanofluid flow and heat transfer reveals that the effect of wall thermal inertia was not investigated in MHD natural convection of nanofluids in an inclined enclosure. The aim of the present study is to analyze conjugate heat transfer in an inclined cavity filled with water and Al2O3.
Run for the hills: Italian investors' risk appetite before and during the financial crisis
Authors: Lippi Andrea , Rossi Simone 
Published: June 2020

PurposeThis paper sets out to corroborate the existing literature on investors' risk tolerance and to assess how the 2008 financial crisis has affected risk tolerance among Italian investors.Design/methodology/approachBased on a unique dataset of real-world portfolio choices made by 1,245 Italian investors over a period of 15 years (from 2003 to 2017), this paper presents two steps of analysis. In step 1, the whole period 2003–2017 is considered with the aim to integrate and corroborate the existing literature on the topic of risk tolerance, considering a complete economic and financial cycle. Step 2 took 2008 as the pivotal point between pre-crisis (2003–2008) and crisis (2009–2017) with the aim to observe the influence on risk appetite of the economic and financial effects of the crisis.FindingsThe results obtained confirm that men are more risk tolerant than women and older people are less risk-taking than their younger counterparts, although the relationship between age and risk tolerance is not necessarily linear. Moreover, our paper demonstrates that a crisis scenario has an influence on Italian investors' risk tolerance.Practical implicationsOur results are of interest to financial advisors, financial planners, asset managers, psychologists, behavioral researchers and more in general to providers of financial products and services.Originality/valueThe results presented in this paper are relevant and original because they are based on real investors who made real choices concerning their portfolio asset allocations.
An empirical study of purchase intention of energy-efficient home appliances: the influence of knowledge of eco-labels and psychographic variables
Authors: Waris Idrees , Hameed Irfan 
Published: June 2020

Purpose
The purpose of this study is to empirically evaluate the antecedents of consumers’ purchase intention of energy-efficient home appliances.

Design/methodology/approach
A self-administered questionnaire has been used to gather data from the targeted representatives of the population. Quota based on age and convenience sampling techniques were used to select the participants of the study, as it is a suitable technique in situations where the possibility of getting a complete sampling frame is difficult. More than 73% of the population of Pakistan is aged below 34 years (Pakistan Bureau of Statistics, 2017). Based on this information, the current study has allocated more than 75% quota to consumers who are below 35 years.

Findings
The findings of the study reveal that all antecedents have significant impact on consumers’ purchase intention of energy-efficient home appliances. Environmental concern, green trust and products’ functional values are most influencing factors in the purchase of energy-efficient home appliances.

Originality/value
This study is related to energy-efficient home appliances in Pakistan. Systematic literature suggested the need to analyze the antecedents of energy-efficient appliances. This study helps the practitioners and marketers to understand consumers’ behavior regarding the purchase of energy-efficient home appliances.
Inventory and ordering decisions: a systematic review on research driven through behavioral experiments
Authors: Perera H. Niles , Fahimnia Behnam , Tokar Travis 
Published: June 2020

PurposeThe success of a supply chain is highly reliant on effective inventory and ordering decisions. This paper systematically reviews and analyzes the literature on inventory ordering decisions conducted using behavioral experiments to inform the state-of-the-art.Design/methodology/approachThis paper presents the first systematic review of this literature. We systematically identify a body of 101 papers from an initial pool of over 12,000.FindingsExtant literature and industry observations posit that decision makers often deviate from optimal ordering behavior prescribed by the quantitative models. Such deviations are often accompanied by excessive inventory costs and/or lost sales. Understanding how humans make inventory decisions is paramount to minimize the associated consequences. To address this, the field of behavioral operations management has produced a rich body of research on inventory decision-making using behavioral experiments. Our analysis identifies primary research clusters, summarizes key learnings and highlights opportunities for future research in this critical decision-making area.Practical implicationsThe findings will have a significant impact on future research on behavioral inventory ordering decisions while informing practitioners to reach better ordering decisions.Originality/valuePrevious systematic reviews have explored behavioral operations broadly or its subdisciplines such as judgmental forecasting. This paper presents a systematic review that specifically investigates the state-of-the-art of inventory ordering decisions using behavioral experiments.
Migrant health situation when detained in European immigration detention centres: a synthesis of extant qualitative literature
Authors: Van Hout Marie-Claire , Lungu-Byrne Cassie , Germain Jennifer 
Published: June 2020

Purpose
Many migrants are detained in Europe not because they have committed a crime but because of lack of certainty over their immigration status. Although generally in good physical health on entry to Europe, migrant detainees have complex health needs, often related to mental health. Very little is known about the current health situation and health care needs of migrants when detained in European immigration detention settings. The review aims to synthesize the qualitative literature available on this issue from the perspectives of staff and migrants.

Design/methodology/approach
The authors undertook a synthesis of extant qualitative literature on migrant health experience and health situation when detained in European immigration detention settings; retrieved as part of a large-scale scoping review. Included records (n = 4) from Sweden and the UK representing both detainee and staff experiences were charted, synthesised and thematically analysed.

Findings
Three themes emerged from the analysis, namely, conditions in immigration detention settings, uncertainties and communication barriers and considerations of migrant detainee health. Conditions were described as inhumane, resembling prison and underpinned by communication difficulties, lack of adequate nutrition and responsive health care.

Practical implications
It is crucial that the experiences underpinning migration are understood to respond to the health needs of migrants, uphold their health rights and to ensure equitable access to health care in immigration detention settings.

Originality/value
There is a dearth of qualitative research in this area because of the difficulty of access to immigration detention settings for migrants. The authors highlight the critical need for further investigation of migrant health needs, so as to inform appropriate staff support and health service responses.
Why do some SME's become high-growth firms? The role of employee competences
Authors: Eklund Carita Mirjami 
Published: June 2020

PurposeHigh-growth firms generate a large share of new jobs and are thus the key drivers of innovation and industry dynamics. As the employees' education supports innovation and productivity, this article hypothesizes that employee competences explain high growth.Design/methodology/approachThe study approaches this by examining intangible capital and specialized knowledge to evaluate how these characteristics support the probability of becoming a high-growth firm. The estimation uses linked employer–employee data from Danish registers from 2005 to 2013.FindingsAs the authors measure high growth with the size-neutral Birch index, they can examine the determinants of high growth across different firm size classes. The findings imply that intangible capital relates positively to the firm's high growth.Originality/valuePrevious research on high-growth firms is concentrated on the owners’ education. This article broadens to the high education of all employees and accounts for the employees’ occupation and capitalization of knowledge with intangible capital.
Harnessing the waiting experience: anticipation, expectations and WOM
Authors: Krishen Anjala S. , Berezan Orie , Agarwal Shaurya , Robison Brian 
Published: June 2020

Purpose
This study aims to explore the anticipated emotions of consumers and their anticipated perceived quality (PQ) of an exhibit, event or service that they are waiting to attend.

Design/methodology/approach
The study consists of a quantitative survey-based descriptive study of n = 470 real-world consumers from a waiting line at the Shark Reef exhibit in Mandalay Bay Resort and Casino, Las Vegas. Data is analyzed with fuzzy-set qualitative comparative analysis (fsQCA) to extrapolate causal conditions or recipes, for word of mouth (WOM) generation regarding the exhibit.

Findings
Recipes that influence positive WOM for an upcoming exhibit include: affect evaluation and affect expectations (AEXs) and affect evaluation, affect expectation, event entertainment and PQ.

Practical implications
By recognizing the need to optimize the customer waiting experience, services marketing managers can more successfully engage customers and influence their subsequent intentions.

Originality/value
Emotions regarding the anticipation of an upcoming event are critical to cultivating the intent to spread positive WOM.