bluuebunny/crossref_metadata_2025_split huggingface dataset:
TFA: an efficient and precise virtual methodcall resolution for Java
Authors: Zhuo Xilong , Zhang Chenyi 
Published: October 2020

Abstract
The problem of statically resolving virtual method calls in object-oriented (OO) programming languages has been a long standing challenge, often due to the overly complicated class hierarchy structures in modern OO programming languages such as Java, C# and C++. Traditional ways of dealing with this problem include class hierarchy analysis (CHA), variable type analysis (VTA), and retrieval of type information after a sophisticated points-to analysis. In this paper, we tackle this problem by proposing a new approach called type flow analysis (TFA) which propagates type information as well as field access information through the syntactic structure of a program. Our methodology is purely algebraic and there is no need to explicitly construct a heap abstraction. We have assessed our methodology from two perspectives. Regarding its theoretical foundation, we have proved that in the context insensitive setting, our method is as precise as the standard Andersen’s subset based points-to analysis regarding the derived types for variables. For an experimental evaluation of TFA, we have implemented the algorithm in the Soot framework and used it to analyze the SPECjvm2008 benchmark suite. During the experiment, we have shown that our method is usually 30–100 times faster than the standard points-to analysis. We further conduct a range of detailed analysis based on the baseline data obtained by running a dynamic profiler, which is also implemented by us, on the SPECjvm2008. The experiment results confirm that TFA can achieve outstanding performance with acceptable accuracy when applied on real-world Java programs.
Influence of fibre orientation on cutting force in up and down milling of UD-CFRP composites
Authors: Geier Norbert 
Published: October 2020

AbstractMachining of carbon fibre reinforced polymer (CFRP) composites is extremely difficult, mainly due to their inhomogeneous and anisotropic properties. Predicting of cutting force during machining of CFRP is also difficult because the machinability properties of the composite are significantly orientation-dependent (fibre and machining directions). The main objective of the present study is to analyse the influence of fibre orientation on cutting force in milling of unidirectional CFRP. Up and down milling experiences were conducted based on a full factorial design. Experimental data were processed by fast Fourier transformation, regression analysis, and graphical adequate analysis. Multiple-order polynomial models were developed in order to minimise cutting force. Experimental results show that fibre orientation angle significantly influences the cutting force; furthermore, it does not have a significant effect on the passive force component, while the radial force component is more sensitive to the fibre orientation at up milling, than at down milling. An optimal condition is recommended for zig-zag milling of unidirectional CFRPs.
Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke
Authors: Rodrigo Gregory , Jaccard Guy , Tafin Djoko Donatien , Korneliou Alexandra , Esposito Marco , Belushkin Maxim 
Published: October 2020

AbstractHealth risk associated with the use of combustible cigarettes is well characterized and numerous epidemiological studies have been published for many years. Since more than a decade, innovative non-combusted tobacco products have emerged like heated tobacco products (HTP) or electronic cigarettes (EC). Long-term effects of these new products on health remain, however, unknown and there is a need to characterize associated potential health risks. The time dedicated to epidemiological data generation (at least 20 to 40 years for cancer endpoint), though, is not compatible with innovative development. Surrogates need, therefore, to be developed. In this work, non-cancer and cancer risks were estimated in a range of HTP and commercial combustible cigarettes based upon their harmful and potentially harmful constituent yields in aerosols and smoke, respectively. It appears that mean lifetime cancer risk values were decreased by more than one order of magnitude when comparing HTPs and commercial cigarettes, and significantly higher margin of exposure for non-cancer risk was observed for HTPs when compared to commercial cigarettes. The same approach was applied to two commercial ECs. Similar results were also found for this category of products. Despite uncertainties related to the factors used for the calculations and methodological limitations, this approach is valuable to estimate health risks associated to the use of innovative products. Moreover, it acts as predictive tool in absence of long-term epidemiological data. Furthermore, both cancer and non-cancer risks estimated for HTPs and ECs highlight the potential of reduced risk for non-combusted products when compared to cigarette smoking.
Ripples in Graphene: A Variational Approach
Authors: Friedrich Manuel , Stefanelli Ulisse 
Published: October 2020

AbstractSuspended graphene samples are observed to be gently rippled rather than being flat. In Friedrich et al. (Z Angew Math Phys 69:70, 2018), we have checked that this nonplanarity can be rigorously described within the classical molecular-mechanical frame of configurational-energy minimization. There, we have identified all ground-state configurations with graphene topology with respect to classes of next-to-nearest neighbor interaction energies and classified their fine nonflat geometries. In this second paper on graphene nonflatness, we refine the analysis further and prove the emergence of wave patterning. Moving within the frame of Friedrich et al. (2018), rippling formation in graphene is reduced to a two-dimensional problem for one-dimensional chains. Specifically, we show that almost minimizers of the configurational energy develop waves with specific wavelength, independently of the size of the sample. This corresponds remarkably to experiments and simulations.
Intensity dependent effect of cognitive training on motor cortical plasticity and cognitive performance in humans
Authors: Berns Christina , Brüchle Wanja , Scho Sebastian , Schneefeld Jessica , Schneider Udo , Rosenkranz Karin 
Published: October 2020

AbstractIntervention-induced neuroplastic changes within the motor or cognitive system have been shown in the human brain. While cognitive and motor brain areas are densely interconnected, it is unclear whether this interconnectivity allows for a shared susceptibility to neuroplastic changes. Using the preparation for a theoretical exam as training intervention that primarily engages the cognitive system, we tested the hypothesis whether neuroplasticity acts across interconnected brain areas by investigating the effect on excitability and synaptic plasticity in the motor cortex. 39 healthy students (23 female) underwent 4 weeks of cognitive training while revision time, physical activity, concentration, fatigue, sleep quality and stress were monitored. Before and after cognitive training, cognitive performance was evaluated, as well as motor excitability using transcranial magnetic stimulation and long-term-potentiation-like (LTP-like) plasticity using paired-associative-stimulation (PAS). Cognitive training ranged individually from 1 to 7 h/day and enhanced attention and verbal working memory. While motor excitability did not change, LTP-like plasticity increased in an intensity-depending manner: the longer the daily revision time, the smaller the increase of neuroplasticity, and vice versa. This effect was not influenced by physical activity, concentration, fatigue, sleep quality or stress. Motor cortical plasticity is strengthened by a behavioural intervention that primarily engages cognitive brain areas. We suggest that this effect is due to an enhanced susceptibility to LTP-like plasticity, probably induced by heterosynaptic activity that modulates postsynaptic excitability in motorcortical neurones. The smaller increase of PAS efficiency with higher cognitive training intensity suggests a mechanism that balances and stabilises the susceptibility for synaptic potentiation.
Intraoperative OCT bei Netzhautablösung mit Makulabeteiligung
Authors: Degenhardt V. , Khoramnia R. , Storr J. , Mayer C. S. 
Published: October 2020

Zusammenfassung
Hintergrund
Seit wenigen Jahren ermöglicht die intraoperative optische Kohärenztomographie (iOCT) die Darstellung retinaler Strukturen im Operationsmikroskop.

Ziel
Das Ziel dieser Studie ist die Analyse des Verhaltens der Netzhaut und die morphologische Befundung während Operationen bei Ablatio retinae mit Makulabeteiligung.

Methoden
Retrospektive Analyse von 41 konsekutiven Augen mit Makula-off-Ablatio, welche mittels Pars-plana-Vitrektomie (ppV) unter Verwendung von iOCT behandelt wurden, durch qualitative Beurteilung der Netzhautmorphologie zu definierten Zeitpunkten im OP-Ablauf.

Ergebnisse
In 63 % der Fälle gelang die iOCT-Darstellung der abgehobenen Makula, in den anderen Fällen überstieg die Netzhautabhebung die maximale Scantiefe der iOCT. Unter Perfluorodecalin zeigten 53,7 % der Augen noch subretinale Flüssigkeit, und 22 % der Augen zeigten eine Falte der äußeren Netzhautschichten. In 61 % der Augen konnte persistierende subretinale Flüssigkeit unter der endgültigen Tamponade festgestellt werden. Die subretinale Flüssigkeit konnte intraoperativ in dieser Menge mit bloßem Auge nicht festgestellt werden. In einem Fall konnte intraoperativ ein Makulaformen neu erkannt werden, in 3 Fällen zeigte sich zum Operationszeitpunkt eine wieder anliegende Makula.

Diskussion
Die Informationen der iOCT führen eher selten zu einer Änderung oder Erweiterung des Eingriffs. Sie liefert jedoch in Echtzeit neue Informationen über intra- und subretinale Flüssigkeitsverteilung, die nicht immer der klinischen Einschätzung entsprechen. Die Bedeutung von persistierender subretinaler Flüssigkeit und die Falten der äußeren Netzhautschichten am Ende der Operation sind noch unklar. Sie könnten möglicherweise als prognostischer Faktor für das postoperative Outcome dienen.
Non-idiopathic peripheral facial palsy: prognostic factors for outcome
Authors: Geißler Katharina , Urban Elisabeth , Volk Gerd F. , Klingner Carsten M. , Witte Otto W. , Guntinas-Lichius Orlando 
Published: October 2020

Abstract
Objectives
There is a lack of data on patients’ and diagnostic factors for prognostication of complete recovery in patients with non-idiopathic peripheral facial palsy (FP).

Methods
Cohort register-based study of 264 patients with non-idiopathic peripheral FP and uniform diagnostics and standardized treatment in a university hospital from 2007 to 2017 (47% female, median age: 57 years). Clinical data, facial grading, electrodiagnostics, motor function tests, non-motor function tests, and onset of prednisolone therapy were assessed for their impact on the probability of complete recovery using univariable and multivariable statistics.

Results
The most frequent reason for a non-idiopathic peripheral FP was a reactivation of Varicella Zoster Virus (VZV; 36.4%). Traumatic origin had a higher proportion of complete FP (52.9%). Furthermore, in traumatic FP, the mean interval between onset and start of prednisolone therapy was longer than in other cases (5.6 ± 6.2 days). Patients with reactivation of VZV, Lyme disease or otogenic FP had a significant higher recovery rate (p = 0.002, p < 0.0001, p = 0.018, respectively), whereas patients with post-surgery FP and other reasons had a significant lower recovery rate (p < 0.0001). After multivariate analyses voluntary activity in first EMG, Lyme disease and post-surgery cause were identified as independent diagnostic and prognostic factors on the probability of complete recovery (all p < 0.05).

Conclusion
Infectious causes for non-idiopathic FP like VZV reactivation and Lyme disease had best probability for complete recovery. Post-surgery FP had a worse prognosis.

Level of evidence
2
Clinical characteristics and prognosis of elderly nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy
Authors: Lyu Yingchen , Ni Mengshan , Zhai Ruiping , Kong Fangfang , Du Chengrun , Hu Chaosu , Ying Hongmei 
Published: October 2020

Abstract
Purpose
To evaluate the clinical characteristics and prognosis of elderly nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy (IMRT).

Methods
From June 2008 to October 2014, 148 newly diagnosed non-metastatic elderly NPC patients (aged ≥ 70 years) receiving IMRT were recruited. Comorbid condition was evaluated using the age-adjusted Charlson Comorbidity Index (ACCI). Kaplan–Meier method was used to estimate survival rates and the differences were compared using log-rank test. Hazard ratio (HR) and the associated 95% confidence interval (CI) were calculated using Cox proportional hazard model by means of multivariate analysis.

Results
The median follow-up time was 66.35 months. Estimated OS rate at 5 years for the entire group was 61.8% (95% confidence interval [CI] 0.542–0.703). The 5-year OS rate of RT alone group was 58.4% (95% [CI] 0.490–0.696) compared with 65.2% (95% [CI] 0.534–0.796) in CRT group (p = 0.45).
In patients receiving IMRT only, ACCI score equal to 3 was correlated with superior 5-year OS rate in comparison with higher ACCI score 62.1% (95% [CI] 0.510–0.766) to 48.5% (95% [CI] 0.341–0.689), respectively; p = 0.024). A 5-year OS rate of 63.1% (95% [CI] 0.537–0.741) was observed in patients younger than 75 years old compared with 57.5% (95% [CI] 0.457–0.723) in patients older (p = 0.026). Patients with early-stage disease (I–II) showed better prognosis than patients with advanced-stage (III–IV) disease (5-year OS, 72.3–55.4%, respectively; p = 0.0073). The Cox proportional hazards model suggested that age independently predicted poorer OS (HR, 1.07; 95%CI 1.00–1.15, p = 0.04).

Conclusion
The survival outcome of patients aged ≥ 70 years receiving IMRT only was similar to chemoradiotherapy with significantly less acute toxicities. Among the population, age is significantly prognostic for survival outcomes.
Use of barbed suture without fashioning the “classical” Wirsung-jejunostomy in a modified end-to-side robotic pancreatojejunostomy
Authors: Morelli Luca , Furbetta Niccolò , Gianardi Desirée , Guadagni Simone , Di Franco Gregorio , Bianchini Matteo , Palmeri Matteo , Masoni Caterina , Di Candio Giulio , Cuschieri Alfred 
Published: October 2020

Abstract
Background
The treatment of the pancreatic stump is a critical step of pancreatoduodenectomy (PD). Robot-assisted surgery (RAS) can facilitate minimally invasive challenging abdominal procedures, including pancreatojejunostomy. However, one of the major limitations of RAS stems from its lack of tactile feedback that can lead to pancreatic parenchyma laceration during knot tying or during traction on the suture. Moreover, a Wirsung-jejunostomy is not always easy to execute, especially in cases with small diameter duct. Herein, we describe and video-report the technical details of a robotic modified end-to-side invaginated robotic pancreatojejunostomy (RmPJ) with the use of barbed suture instead of the “classical” Wirsung-jejunostomy.

Methods
The RmPJ technique consists of a double layer of absorbable monofilament running barbed suture (3–0 V-Loc), the outer layer is used to invaginate the pancreatic stump. Thereafter, a small enterotomy is made in the jejunum exactly opposite to the location of the pancreatic duct for stent insertion (usually 5 Fr) inside the duct. The internal layer provides a second barbed running suture placed between the pancreatic capsule/parenchyma and the jejunal seromuscular layer.

Results
A total of 14 patients underwent robotic PD with RmPJ at our Institution. The mean console time was (281.36 ± 31.50 min), while the mean operative time for fashioning the RmPJ was 37.31 ± 7.80 min. Ten out of 14 patients were discharged within postoperative day 8. No clinically relevant pancreatic fistulas were encountered, while two patients developed biochemical leaks.

Conclusions
RmPJ is feasible and reproducible irrespective of pancreatic duct size and parenchyma, and can enhance the surgical workflow of this operation. Specifically, the use of barbed sutures allows the exploitation of the potential advantages of the RAS, while minimizing the negative effect caused by the main disadvantage of the robotic approach, its absence of tactile feedback, by ensuring uniform tension on the continuous suture lines used, especially during the reconstructive phase of the operation.
Different retinopathy phenotypes in type 2 diabetes predict retinopathy progression
Authors: Marques Inês P. , Madeira Maria H. , Messias Ana L. , Martinho António C.-V. , Santos Torcato , Sousa David C. , Figueira João , Cunha-Vaz José 
Published: October 2020

Abstract
Purpose
To characterize the progression in retinopathy severity of different phenotypes of mild nonproliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes.

Design and methods
Patients with type 2 diabetes and mild NPDR (ETDRS 20 or 35) were followed in a 5-year longitudinal study. Examinations, including color fundus photography (CFP) and optical coherence tomography (OCT and OCTA), were performed at baseline, 6 months and then annually. Phenotype classification was performed based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Phenotype A is characterized by low MAT (< 6) and normal CRT; Phenotype B by low MAT (< 6) and increased CRT; and Phenotype C by higher MAT (≥ 6) with or without increased CRT. ETDRS grading of seven fields CFP was performed at the initial and last visits.

Results
Analysis of ETDRS grade step changes showed significant differences in diabetic retinopathy (DR) progression between the different phenotypes (p < 0.001). Of the 66 participants with phenotype A only 2 eyes (3%) presented 2-or-more-step worsening. None of the 50 participants characterized as phenotype B developed 2-step worsening, whereas 13 eyes (23.2%) characterized as phenotype C had 2-or-more-steps worsening. Phenotype C presents the higher risk for 2-or-more step worsening (OR: 15.94 95% CI: 3.45–73.71; p < 0.001) and higher sensitivity, correctly identifying 86.7% of cases at risk (AUC: 0.84 95% CI: 0.72–0.96; p < 0.001). Diabetic retinopathy severity progression was associated with HbA1c (p = 0.019), LDL levels (p = 0.043), and ocular factors as MAT (p = 0.010), MA formation rate (p = 0.014) and MA disappearance rate (p = 0.005). Capillary closure at 5-year follow-up, identified by lower vessel density (VD) on OCTA, was also associated with diabetic DR severity progression (p = 0.035).

Conclusions
Different DR phenotypes in type 2 diabetes show different risks of retinopathy progression. Phenotype C is associated with increased HbA1c values and presents a higher risk of a 2-or-more-step worsening of the ETDRS severity score.
The Use of Single-Sided NMR to Study Moisture Behaviour in an Activated Carbon Fibre/Phenolic Composite
Authors: Alston Sue , Arnold Cris , Swan Martin , Stone Corinne 
Published: October 2020

AbstractNuclear Magnetic Resonance (NMR) has been shown to be a useful technique to study the form and content of water in polymer composites. Composites using activated carbon fibres with phenolic resin have complex water absorption behaviour which would benefit from such investigation; however, the presence of the conductive fibres can make NMR problematic. In this study, single-sided NMR has been successfully used on such material by developing a method for sample-to-sample compensation for the effect of conductivity. Transverse relaxation curves showed water to be primarily in two states in the resin, corresponding to "bound" and "mobile" molecules. In addition, two much less bound states were identified in the composite, associated firstly with water adsorbed on to the fibre surface and secondly with clusters of water molecules moving more freely within the fibre pores.
Accuracy and longitudinal reproducibility of quantitative femorotibial cartilage measures derived from automated U-Net-based segmentation of two different MRI contrasts: data from the osteoarthritis initiative healthy reference cohort
Authors: Wirth Wolfgang , Eckstein Felix , Kemnitz Jana , Baumgartner Christian Frederik , Konukoglu Ender , Fuerst David , Chaudhari Akshay Sanjay 
Published: October 2020

Abstract
Objective
To evaluate the agreement, accuracy, and longitudinal reproducibility of quantitative cartilage morphometry from 2D U-Net-based automated segmentations for 3T coronal fast low angle shot (corFLASH) and sagittal double echo at steady-state (sagDESS) MRI.

Methods
2D U-Nets were trained using manual, quality-controlled femorotibial cartilage segmentations available for 92 Osteoarthritis Initiative healthy reference cohort participants from both corFLASH and sagDESS (n = 50/21/21 training/validation/test-set). Cartilage morphometry was computed from automated and manual segmentations for knees from the test-set. Agreement and accuracy were evaluated from baseline visits (dice similarity coefficient: DSC, correlation analysis, systematic offset). The longitudinal reproducibility was assessed from year-1 and -2 follow-up visits (root-mean-squared coefficient of variation, RMSCV%).

Results
Automated segmentations showed high agreement (DSC 0.89–0.92) and high correlations (r ≥ 0.92) with manual ground truth for both corFLASH and sagDESS and only small systematic offsets (≤ 10.1%). The automated measurements showed a similar test–retest reproducibility over 1 year (RMSCV% 1.0–4.5%) as manual measurements (RMSCV% 0.5–2.5%).

Discussion
The 2D U-Net-based automated segmentation method yielded high agreement compared with manual segmentation and also demonstrated high accuracy and longitudinal test–retest reproducibility for morphometric analysis of articular cartilage derived from it, using both corFLASH and sagDESS.
Flow of colloidal suspension and irreversibility analysis with aggregation kinematics of nanoparticles in a microchannel
Authors: Sindhu S. , Gireesha B. J. 
Published: October 2020

AbstractThe current exploration focuses on the ethylene glycol (EG) based nanoliquid flow in a microchannel. The effectiveness of the internal heat source and linear radiation is reflected in the present investigation. The estimation of suitable thermal conductivity model has affirmative impact on the convective heat transfer phenomenon. The examination is conceded with the nanoparticle aggregation demonstrated by the Maxwell-Bruggeman and Krieger-Dougherty models which tackle the formation of nanolayer. These models effectively describe the thermal conductivity and viscosity correspondingly. The dimensionless mathematical expressions are solved numerically by the Runge Kutta Fehlberg approach. A higher thermal field is attained for the Bruggeman model due to the formation of thermal bridge. A second law analysis is carried out to predict the sources of irreversibility associated with the thermal system. It is remarked that lesser entropy generation is obtained for the aggregation model. The entropy generation rate declines with the slip flow and the thermal heat flux. A notable enhancement in the Bejan number is attained by increasing the Biot number. It is established that the nanoparticle aggragation model exhibits a higher Bejan number in comparision with the usual flow model.