bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin triggers the anticancer potential of phenylarsine oxide via induction of apoptosis through ROS generation and JNK activation
Authors: Zakki Shahbaz Ahmad , Muhammad Jibran Sualeh , Li Jin-Long , Sun Lu , Li Meng-Ling , Feng Qian-Wen , Li Yu-Lin , Cui Zheng-Guo , Inadera Hidekuni 
Published: December 2019

Abstract
Melatonin, a safe endogenous hormone and a natural supplement, has recently been recognized to have antiproliferative effects and the ability to sensitize cells to other anticancer therapies. Phenylarsine oxide (PAO) has anticancer potential but it is considered as a toxic agent. In this study we combined melatonin to reduce the toxicity while securing the anti-cancer effects of PAO. Cell viability was determined by MTT assay, whereas cytotoxic assays were performed using an LDH cytotoxicity assay kit. Cell cycle analysis, Annexin V/PI staining, the mitochondrial membrane potential (MMP), mitochondrial calcium and reactive oxygen species (ROS) generation were analyzed using flow cytometry. Sytox stained cells were visualized by fluorescence microscopy and the expression of proteins was detected by western blotting. Melatonin increased the anticancer potential of PAO by decreasing the cell viability and increasing LDH release in various cancer cells. The mode of cell death was determined to be typical apoptosis, as evidenced by Annexin V/PI-stained cells, PARP cleavage, and caspase-3 activation, and with significant modulations in the expression of proapoptotic, antiapoptotic and cell cycle-related proteins. ROS generation played a critical role in induction of cell death by this combined treatment, which is validated by reversal of cytotoxicity upon cotreatment with NAC. Furthermore, the activation of MAPKs, especially JNK, contributed to the induction of cell death, accompanied by endoplasmic reticulum stress and autophagy, affirmed by the abrogation of cytotoxicity after JNK-IN-8 and TUDCA application. Melatonin showed promising potential as a chemotherapeutic agent in combination with PAO to achieve a better anticancer response.
The Classification Accuracy of a Dynamic Assessment of Inferential Word Learning for Bilingual English/Spanish-Speaking School-Age Children
Authors: Petersen Douglas B. , Tonn Penny , Spencer Trina D. , Foster Matthew E. 
Published: December 2019

Purpose
Educators often use results from static norm-referenced vocabulary assessments to aid in the diagnosis of school-age children with a language disorder. However, research has indicated that many of these vocabulary assessments yield inaccurate, biased results, especially with culturally and linguistically diverse children. This study examined whether the use of a dynamic assessment of inferential word learning was more accurate at identifying bilingual (English/Spanish-speaking) children with a language disorder when compared to static measures of vocabulary.

Method
Thirty-one bilingual Spanish/English school-age children—21 children with typical language and 10 children with a language disorder—ages 5;9–9;7 (years;months) were administered traditional static vocabulary assessments and a dynamic assessment of inferential word learning that used a test–teach–test design.

Results
Discriminant analysis and logistic regression indicated that the combined posttest scores and modifiability ratings from the dynamic assessment generated 90%–100% sensitivity and 90.5%–95.2% specificity, which were superior to the static vocabulary tests.

Conclusion
These preliminary findings suggest that dynamic assessment of inferential word learning may be an effective method for accurately identifying diverse children with a language disorder.
Reconfigurable WPT system for load‐independent CC and CV output with transmitting‐side control
Authors: Vaka Ravikiran , Keshri Ritesh Kumar 
Published: December 2019

This study proposes a reconfigurable wireless charging topology, which achieves load‐independent constant current (CC) and constant voltage (CV) output without any communication link between transmitting and receiving coils. The proposed topology is suitable for CC–CV modes of battery charging. Inductor (L), capacitor (C) and inductor (L) connected as T type (LCL) compensation with an auxiliary capacitor on the transmitting side and series (S) compensation on the receiving side (LCL‐S) is used to achieve load‐independent CC and CV output. Reconfiguration has been achieved using single AC switch on transmitting side. Control has been implemented with the information on transmitting side. Load‐independent CC and CV output operations have been analysed analytically. The merits of the proposed topology are fixed‐frequency operation, simplified control scheme for load‐independent CC–CV operation without any communication link. Feasibility of the proposed topology is verified by the experimental prototype with a CC output of 12 A and CV output of 56 V.
Novel MTPA control strategy for IPMSM based on multiple virtual signals injection
Authors: Chen Bao , Shen Anwen , Luo Xin , Dou Zhaolei , Luo Pan 
Published: December 2019

Virtual signal injection‐based maximum torque per ampere (MTPA) control method is widely employed for increasing the efficiency of the interior permanent magnet synchronous machine (IPMSM) due to its simple implementation. However, the conventional method utilises the filters to extract MTPA indicator, which limits the dynamic tracking performance of MTPA operating point. In order to improve the dynamic tracking performance, a novel strategy to use multiple virtual signals injection is proposed in this study. With the proposed method, four small virtual high‐frequency signals are constructed to extract the MTPA indicator information. The MTPA indicator can be calculated directly by solving multiple acquired equations instead of any filters. Due to the absence of filters which are essential in the conventional method, this proposed method shows good dynamic response. The feasibility of the proposed method is verified under various operating conditions with a 1.2 kW IPMSM drive system.
Synthesis of quaternary nano‐intermetallic LaTi2Ni5Al4 with its hydrogen encapsulation and inspection using lithium‐hydride cell
Authors: Jaafar Hassen , Dhiab Arij , Slama Chiheb , Sahli Ines , Abdellaoui Mohieddine 
Published: December 2019

A novel alloy LaTi2Ni5Al4 is investigated in this work. This quaternary composite belongs to the new generation of AB3 intermetallics elaborated using the mechano‐milling method. Several analytical techniques are operated in order to verify and confirm the crystallographic patterns following the growth progression of this nanoalloy. Starting from elemental metals, the authors show that they have basically LaTi2Ni5Al4 major pattern corresponding to the symmetry crystal system (Trigonal R‐3 m SG: 166). Structure refinement simulation demonstrates that performing this preparation with a laboratory grinding and milling benchtop, they obtain a maximum proportion of AB3 intermetallic alloy after 20 h of metallurgy work processing. The proposition of useful stabilised solid‐hydrogen encapsulation is highlighted and tested using a specific lithium‐hydride cell.
Impact of ion irradiation, elemental doping and coating cycles on structural characteristic parameters of nanocrystalline VO2 thin films
Authors: Khan G.R. 
Published: December 2019

The origin of the structural phase transition in vanadium dioxide (VO2) has been the subject of immense disagreement in spite of decades of research carried out to comprehend this intriguing phenomenon. Diverse models have been developed to elucidate the obscure theory in order to corroborate assorted experimental results. Herein, the influence of swift heavy ion irradiation, elemental doping and coating cycles on the structural properties of thin films synthesised by sol–gel technique and deposited by spin coater on alumina and glass substrates is investigated. The thin films were characterised by X‐ray diffractometry and the XRD spectra obtained at 1E11, 5E11, 1E12 ion beam fluances of 200 MeV Ag9+ ‐ion irradiation; at 1, 3, 5% of Mo6+ ‐ion doping and at different spin coating cycles were analysed to probe the influence of these effects on the structural characteristic parameters of nanocrystallites in VO2 thin films. This aspect of VO2 thin films has not been investigated to its full capacity and consequently, not reported in the scientific literature.
The single star path to Be stars
Authors: Hastings Ben , Wang Chen , Langer Norbert 
Published: December 2019

Context. Be stars are rapidly rotating B main sequence stars that show line emission due to an outflowing disc. By studying the evolution of rotating single star models, we can assess their contribution to the observed Be star populations.
Aims. We identify the main effects that cause single stars to approach critical rotation as functions of initial mass and metallicity, and predict the properties of populations of rotating single stars.
Methods. We perform population synthesis with single-star models of initial masses ranging between 3 and 30 M⊙ and initial equatorial rotation velocities between 0 and 600 km s−1 at compositions representing the Milky Way and the Large and Small Magellanic Clouds. These models include efficient core–envelope coupling mediated by internal magnetic fields and correspond to the maximum efficiency of Be star production. We predict Be star fractions and the positions of fast-rotating stars in the colour–magnitude diagram.
Results. We identify stellar wind mass-loss and the convective core mass fraction as the key parameters determining the time dependance of the stellar rotation rates. Using empirical distributions of initial rotational velocities, our single-star models can reproduce the trends observed in Be star fractions with mass and metallicity. However, they fail to produce a significant number of stars rotating very close to the critical velocity. We also find that rapidly rotating Be stars in the Magellanic Clouds should have significant surface nitrogen enrichment, which may be in conflict with abundance determinations of Be stars.
Conclusions. Single-star evolution might explain the high number of Be stars if 70 to 80% of critical rotation would be sufficient to produce the Be phenomenon. However, even in this case, the unexplained presence of many Be stars far below the cluster turn-off indicates the importance of the binary channel for Be star production.
Exploring Patient Motivations and Impact of Asian Blepharoplasty
Authors: Huynh Pauline P. , Ishii Masaru , Juarez Michelle , Fung Nicholas , Bater Kristin , Darrach Halley , Nellis Jason C. , Bonham Luke W. , Lay P. Chase , Ishii Lisa E. 
Published: December 2019

AbstractTo date, patient motivations for Asian blepharoplasty and the surgery's impact on quality of life have not been quantified. Here, we employed structured interviews and a web-based survey to better characterize patient motivations for Asian blepharoplasty and the impact of Asian blepharoplasty on self-reported domains of happiness, self-esteem, attractiveness, social life, and professional life. Structured interviews were conducted to inform a web-based survey regarding Asian blepharoplasty. Survey respondents used visual analog scales to rate their satisfaction with their eye shape, motivations for undergoing Asian blepharoplasty, and perceived outcomes after surgery. A total of 315 participants (mean 25.7 [18–58] years) of East or Southeast Asian descent were included. 185 participants expressed no desire for Asian blepharoplasty, 76 expressed some desire, and 54 had already undergone surgery. There were statistically significant differences regarding baseline satisfaction, perceived social limitation, and perceived professional limitations regarding eye shape (p < 0.0001). The Looking Glass Self index (comprised of media exposure, low self-esteem, and negative stereotypes related to eye shape) is negatively associated with preoperative satisfaction with eye shape (rho = −0.29, p < 0.01). The desire for social-professional advancement and the Looking Glass Self index significantly predict self-reported improvements in professional and social life, respectively (both p < 0.01). Asian blepharoplasty may be driven by functional, social, or economic patient motivations. Some patients may see Asian blepharoplasty as a potential solution for sociological concerns. These expectations should be further explored in physician–patient discussions regarding candidacy for surgery and establishing expectations for postoperative outcomes.
Experimental time resolution limits of modern SiPMs and TOF-PET detectors exploring different scintillators and Cherenkov emission
Authors: Gundacker Stefan , Martinez Turtos Rosana , Kratochwil Nicolaus , Pots Rosalinde Hendrika , Paganoni Marco , Lecoq Paul , Auffray Etiennette 
Published: December 2019

Abstract
Solid state photodetectors like silicon photomultipliers (SiPMs) are playing an important role in several fields of medical imaging, life sciences and high energy physics. They are able to sense optical photons with a single photon detection time precision below 100 ps, making them ideal candidates to read the photons generated by fast scintillators in time of flight positron emission tomography (TOF-PET). By implementing novel high-frequency readout electronics, it is possible to perform a completely new evaluation of the best timing performance achievable with state-of-the-art analog-SiPMs and scintillation materials. The intrinsic SiPM single photon time resolution (SPTR) was measured with Ketek, HPK, FBK, SensL and Broadcom devices. Also, the best achieved coincidence time resolution (CTR) for these devices was measured with LSO:Ce:Ca of

mm3 and

mm3 size crystals. The intrinsic SPTR for all devices ranges between 70 ps and 135 ps FWHM when illuminating the entire

mm2 or

mm2 area. The obtained CTR with LSO:Ce:Ca of

mm3 size ranges between 58 ps and 76 ps FWHM for the SiPMs evaluated. Bismuth Germanate (BGO), read out with state of-the-art NUV-HD SiPMs from FBK, achieved a CTR of 158

ps and 277

ps FWHM for

mm3 and

mm3 crystals, respectively. Other BGO geometries yielded 167

3 ps FWHM for

mm3 and 235

5 ps FWHM for

mm3 also coupled with Meltmount (n  =  1.582) and wrapped in Teflon. Additionally, the average number of Cherenkov photons produced by BGO in each 511 keV event was measured to be 17

3 photons. Based on this measurement, we predict the limits of BGO for ultrafast timing in TOF-PET with Monte Carlo simulations. Plastic scintillators (BC422, BC418), BaF2, GAGG:Ce codoped with Mg and CsI:undoped were also tested for TOF performance. Indeed, BC422 can achieve a CTR of 35

2 ps FWHM using only Compton interactions in the detector with a maximum deposited energy of 340 keV. BaF2 with its fast cross-luminescence enables a CTR of 51

5 ps FWHM when coupled to VUV-HD SiPMs from FBK, with only  ∼22% photon detection efficiency (PDE). We summarize the measured CTR of the various scintillators and discuss their intrinsic timing performance.
Markovian treatment of non-Markovian dynamics of open Fermionic systems
Authors: Chen Feng , Arrigoni Enrico , Galperin Michael 
Published: December 2019

Abstract
We show that an open fermionic system coupled to a continuous environment with unitary system-environment evolution can be exactly mapped onto an auxiliary system consisting of the physical fermion system and a set of discrete fermionic modes subject to non-unitary Lindblad-type system-modes evolution in such a way that reduced dynamics of the fermionic system in the two cases are the same. Conditions for equivalence of reduced dynamics in the two systems are identified and a proof is presented. Our study extends recent work on Bose systems (Tamascelli et al 2018 Phys. Rev. Lett. 120 030402) to the case of open quantum Fermi systems and to multi-time correlation functions. Numerical simulations within a generic junction model are presented for illustration.
Efficient generation of nitrogen vacancy centers by laser writing close to the diamond surface with a layer of silicon nanoballs
Authors: Rong Youying , Ju Zhiping , Ma Qiang , Liu Shikang , Pan Chengda , Wu Botao , Shen Si , Wu E 
Published: December 2019

Abstract
We proposed a method to effectively fabricate negatively charged nitrogen vacancy (NV−) centers close to the diamond surface by applying femtosecond laser writing technique. With a thick layer of silicon (Si) nanoballs coated, diamond surface was irradiated by high-fluence femtosecond laser pulses. A large number of NV− centers were created around the laser ablation crater area without thermal annealing. The distribution of the NV− centers was expanded to about 50 μm away from the crater center. To demonstrate the function of Si nanoballs, we performed the exactly same laser illumination process on the bare region of the sample surface. In this case, only a few NV− centers were generated around ablation crater. At distance of 32 μm away from crater centers, the NV− density for the case with nanoballs was up to 15.5 times higher compared to the case without nanoballs. Furthermore, we also investigated the influence of laser fluence and pulse number on the NV− density for the case with Si-nanoball layer. Finally, the formation mechanism of NV− centers and the role of Si nanoballs were explained via Coulomb explosion model. The method is demonstrated to be a promising approach to efficiently and rapidly fabricate NV− centers close to the surface of the diamond, which are significant in quantum sensing. Furthermore, the results provide deep insights into complex light-matter interactions.
Flat-band many-body localization and ergodicity breaking in the Creutz ladder
Authors: Kuno Yoshihito , Orito Takahiro , Ichinose Ikuo 
Published: December 2019

Abstract
We study disorder-free many-body localization in the flat-band Creutz ladder, which was recently realized in cold-atoms in an optical lattice. In a non-interacting case, the flat-band structure of the system leads to a Wannier wavefunction localized on four adjacent lattice sites. In the flat-band regime both with and without interactions, the level spacing analysis exhibits Poisson-like distribution indicating the existence of disorder-free localization. Calculations of the inverse participation ratio support this observation. Interestingly, this type of localization is robust to weak disorders, whereas for strong disorders, the system exhibits a crossover into the conventional disorder-induced many-body localizated phase. Physical picture of this crossover is investigated in detail. We also observe non-ergodic dynamics in the flat-band regime without disorder. The memory of an initial density wave pattern is preserved for long times.
The Sound Representation of an Opera House’s Orchestra Pit: The Stereo Dipole Technique
Authors: Vodola V 
Published: December 2019

Abstract
By using 2 or 4 loudspeakers, the stereo dipole technique is able to realize the virtual sound field of an auditorium in an anechoic listening room. Making use of binaural impulse responses (BIRs) measured in the auditorium and the auralization technique, the virtual BIR can be generated. The accuracy of the sound representation is investigated by comparing the real and virtual BIRs. For a well-diffused sound field like concert halls, this technique enables a highly accurate representation of the sound field. Yet, when the sound source is in the small regularly shaped enclosures like an orchestra pit of an opera house, a peculiar amplification contained in the low-frequency range of the measured BIR is still more emphasized in the virtual BIR disturbing the linear sound representation. This study aims for the solution to this problem.
On the 3D Acoustic Analysis in UNESCO Sites: The Example of San Vitale, Ravenna, Italy
Authors: Vodola Vincenzo 
Published: December 2019

Abstract
The study and analysis of the sound field’s 3D properties has been strongly enhanced in recent years after spatial properties of sound propagation have been acknowledged to be important during the design or correction of theatres and auditorium. Besides, a proper assessment of spatial accuracy is requested for 3D sound reproduction systems, initially designed for acoustical virtual reality and now also employed in the entertainment/cinema industry. Often only monoaural or binaural measurements are performed by means of omnidirectional microphones and dummy heads, although international standards like ISO 3382/1:2009 also define some “truly spatial” parameters such as JLF and JLFC. Even though the two latter parameters are derived from measurements made with a pressure velocity (p/v) microphone, they still represent a 2-channel measurement. 3D Impulse Responses (4-channel B-format) have for many years been measured and employed for sound reproduction. Recently, higher-order 3D Impulse Responses have been measurable thanks to the availability of compact microphone arrays employing a much larger number of transducers. In this paper, a procedure for measuring and analyzing the complete spatial sound information is presented, which is aimed to create easy-to-understand images and videos showing the direction-of-arrival of the room reflections. The description of this technique is emphasized and applied in the Basilica of San Vitale, Ravenna, Italy, which represents one UNESCO site.
Study of Groundwater in the Rock Area Using Geoelectric Survey
Authors: Juandi M 
Published: December 2019

Abstract
Investigation of underground water becomes very important because it involves human life. The difficulty experienced by the community is the limited potential of underground water, this is due to the uneven distribution of underground water in an area. The purpose of this study is to investigate the presence of groundwater in subsurface rock areas. Groundwater investigations around the bedrock have been successfully carried out using the geoelectric method. The geoelectric survey with Schlumberger configuration was carried out in the investigation area. The results of the study have been observed zones that contain groundwater around rocks with varying thicknesses of 73.25 meters and 119 meters.
The Renovation of the Teatro Nuovo in Spoleto: Analysis of the Acoustic Quality of an Italian Opera House
Authors: Vodola V 
Published: December 2019

Abstract
After a complete renovation work and a structural and functional improvement, the Teatro Nuovo has been returned to the city of Spoleto (Italy) and its audience as a renewed venue for the renowned global “Two Worlds Festival.” The restoration works of the theatre started in 2003 to improve safety levels and the operational functionality of the machines on the stage, including acoustic performances, to meet the current needs of the show. The local authorities (Umbria Region) committed the University of Bologna for collaborating with the Teatro Nuovo, in order to analyse and improve its acoustic quality. Two acoustic measurement campaigns, respectively before and after restoration of the theatre, were carried out in order to monitor the Concert Hall’s acoustic performance, verifying the preservation of its original acoustic features. In order to control both monoaural and spatial sound distribution, the ESS pre-equalized signal, emitted by means of an omnidirectional loudspeaker, was recorded using a dummy head and a Soundfield probe. The results of the measurements of every campaign are presented and evaluated in this paper. As shown, the acoustic performances of the theatre are globally improved and contribute to excellent perception of the acoustic environment.