bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maturing global CO2 storage resources on offshore continental margins to achieve 2DS emissions reductions
Authors: Ringrose P. S. , Meckel T. A. 
Published: November 2019

AbstractMost studies on CO2 emissions reduction strategies that address the ‘two-degree scenario’ (2DS) recognize a significant role for CCS. For CCS to be effective, it must be deployed globally on both existing and emerging energy systems. For nations with large-scale emissions, offshore geologic CO2 storage provides an attractive and efficient long-term strategy. While some nations are already developing CCS projects using offshore CO2 storage resources, most geographic regions have yet to begin. This paper demonstrates the geologic significance of global continental margins for providing broadly-equitable, geographically-relevant, and high-quality CO2 storage resources. We then use principles of pore-space utilization and subsurface pressure constraints together with analogs of historic industry well deployment rates to demonstrate how the required storage capacity can be developed as a function of time and technical maturity to enable the global deployment of offshore storage for facilitating 2DS. Our analysis indicates that 10–14 thousand CO2 injection wells will be needed globally by 2050 to achieve this goal.
Hyperglycemia and Salivary Gland Dysfunction in the Non-obese Diabetic Mouse: Caveats for Preclinical Studies in Sjögren’s Syndrome
Authors: Allushi Bujana , Bagavant Harini , Papinska Joanna , Deshmukh Umesh S. 
Published: November 2019

AbstractThe Non-obese Diabetic (NOD) mouse model for type I diabetes also develops some features of Sjögren’s syndrome (SS). Since the source of the mice and the environment exert a strong influence on diabetes, this study investigated SS development in NOD mice obtained from two vendors. Female NOD mice from The Jackson Laboratory (JAX) and Taconic Biosciences were monitored for blood glucose and pilocarpine-induced salivation. The gut microbiome was analyzed by 16S rRNA sequencing of stool DNA. At euthanasia, serum cytokines and sialoadenitis severity were evaluated. The onset of diabetes was significantly accelerated in JAX mice compared to Taconic mice. Although the gut microbiome between the two groups was distinct, both groups developed sialoadenitis. There was no correlation between the severity of sialoadenitis and reduced saliva production. Instead, salivary gland dysfunction was associated with hyperglycemia and elevation of serum IL1β, IL16, and CXCL13. Our data suggest that inflammatory pathways linked with hyperglycemia are confounding factors for salivary gland dysfunction in female NOD mice, and might not be representative of the mechanisms operative in SS patients. Considering that NOD mice have been used to test numerous experimental therapies for SS, caution needs to be exerted before advancing these therapeutics for human trials.
Low-cost photodetector architectures fabricated at room-temperature using nano-engineered silicon wafer and sol-gel TiO2 – based heterostructures
Authors: Banerjee Debika , Asuo Ivy M. , Pignolet Alain , Cloutier Sylvain G. 
Published: November 2019

AbstractIn the last decades, significant research has been done on the nanocrystalline forms of titanium dioxide (TiO2). Amorphous TiO2 has not been studied intensively despite being significantly less expensive compared to crystalline TiO2. This study reveals significant improvement in UV-VIS photodetection properties from heterostructures fabricated in ambient environment using n-type silicon nanowire arrays and amorphous TiO2 sol-gel. Our ultra-low-cost UV-VIS photodetectors can cover a wide range of applications. We report fast rise/decay time constants of 0.23 ms/0.17 ms and high responsivity up-to 6.0 A/W in the UV and 25.0 A/W in the visible range under low (1 V) external bias. The large surface area due to the nanowire array architecture leads to 2 orders of magnitude enhancement in photo-response. Besides the final electrode deposition, the entire device fabrication is performed using low-cost, all solution-based methods in ambient conditions. These low-cost UV-Visible broadband photodetectors can potentially serve a wide range of applications.
3D Titania Nanofiber-Like Webs Induced by Plasma Ionization: A New Direction for Bioreactivity and Osteoinductivity Enhancement of Biomaterials
Authors: Beigi Mohammad-Hossein , Safaie Naghmeh , Nasr-Esfahani Mohammad-Hossein , Kiani Amirkianoosh 
Published: November 2019

AbstractIn this study, we describe the formation method of web-like three-dimensional (3-D) titania nanofibrous structures coated on transparent substrate via a high intensity laser induced reverse transfer (HILIRT) process. First, we demonstrate the mechanism of ablation and deposition of Ti on the glass substrates using multiple picosecond laser pulses at ambient air in an explicit analytical form and compare the theoretical results with the experimental results of generated nanofibers. We then examine the performance of the developed glass samples coated by titania nanofibrous structures at varied laser pulse durations by electron microscopy and characterization methods. We follow this by exploring the response of human bone-derived mesenchymal stem cells (BMSCs) with the specimens, using a wide range of in-vitro analyses including MTS assay (colorimetric method for assessing cell metabolic activity), immunocytochemistry, mineralization, ion release examination, gene expression analysis, and protein adsorption and absorption analysis. Our results from the quantitative and qualitative analyses show a significant biocompatibility improvement in the laser treated samples compared to untreated substrates. By decreasing the pulse duration, more titania nanofibers with denser structures can be generated during the HILIRT technique. The findings also suggest that the density of nanostructures and concentration of coated nanofibers play critical roles in the bioreactivity properties of the treated samples, which results in early osteogenic differentiation of BMSCs.
Soil seed burial and competition with surrounding plants determine the emergence and development of seedling of an endangered species Horsfieldia hainanensis Merr. in China
Authors: Liu Xiongsheng , He Yinghui , Xiao Yufei , Wang Yong , Jiang Yinghong , Jiang Yi 
Published: November 2019

AbstractThree well-conserved Horsfieldia hainanensis Merr. populations were used to investigate their soil seed bank and seedling regeneration characteristics and their relationship to environmental factors. The results showed that the seed reserves were low in the H. hainanensis soil seed bank (16.93~24.74 seed/m2). The distribution pattern for the seeds and seedlings in the H. hainanensis populations was aggregated, and they were mainly found around 2–3 m from the mother plant. The seeds in the litter layer and the 5–10 cm soil layer showed no vigor, and only 25.7%~33.3% of the total seeds in the 0–5 cm soil layer were viable affected by the high temperature and humidity, the animals’ eating and poisoning. Affected by the height and coverage of the surrounding herbaceous layer and shrub layer, the seedlings of H. hainanensis could not obtain enough light and nutrients in the competition, resulting in the survival competitiveness of 1- to 3-year-old (1–3a) seedlings in the habitat had been in a weak position and a large number of seedlings died. It would take at least four years for seedlings to develop under the current environmental constraints. It can be concluded that the low seed reserve in the soil seed bank and high mortality of seedlings of H. hainanensis lead to slow or even stagnation of population regeneration, which was an important reason for the endangered of H. hainanensis. Therefore, the next research focus is to explore the influence mechanism of environmental factors on seed germination and seedling growth of H. hainanensis.
Role of synoptic activity on projected changes in upwelling-favourable winds at the ocean’s eastern boundaries
Authors: Aguirre Catalina , Rojas Maisa , Garreaud René D. , Rahn David A. 
Published: November 2019

AbstractThe climate of the ocean’s eastern boundaries is strongly influenced by subtropical anticyclones, which drive a surface wind stress that promotes coastal upwelling of nutrient-rich subsurface water that supports high primary productivity and an abundance of food resources. Understanding the projected response of upwelling-favourable winds to climate change has broad implications for coastal biogeochemistry, ecology, and fisheries. Here we use a reanalysis, an ensemble of global climate simulations, and an objective algorithm to track anticyclones to investigate the projected changes in upwelling-favourable wind events at the California, Canary, Humboldt, and Benguela coastal upwelling systems. Except for the north Pacific, we find consistent poleward shifts of mean and upper percentile daily winds over the ocean basins. We propose that extratropical, synoptic-scale migratory anticyclones that force intense coastal upwelling events—which become more frequent at higher latitudes and less frequent at lower latitudes in the future—play an important role in the projected changes in upwelling-favourable wind events in these coastal upwelling systems. These changes complement large-scale processes such as the poleward shift of the subtropical ridge (STR) and stationary subtropical highs. Hence, both extratropical and tropical processes need to be considered to fully explain projected changes at the coastal upwelling systems under anthropogenic climate change.
Machine learning can accurately predict pre-admission baseline hemoglobin and creatinine in intensive care patients
Authors: Dauvin Antonin , Donado Carolina , Bachtiger Patrik , Huang Ke-Chun , Sauer Christopher Martin , Ramazzotti Daniele , Bonvini Matteo , Celi Leo Anthony , Douglas Molly J. 
Published: November 2019

AbstractPatients admitted to the intensive care unit frequently have anemia and impaired renal function, but often lack historical blood results to contextualize the acuteness of these findings. Using data available within two hours of ICU admission, we developed machine learning models that accurately (AUC 0.86–0.89) classify an individual patient’s baseline hemoglobin and creatinine levels. Compared to assuming the baseline to be the same as the admission lab value, machine learning performed significantly better at classifying acute kidney injury regardless of initial creatinine value, and significantly better at predicting baseline hemoglobin value in patients with admission hemoglobin of <10 g/dl.
Endogenous formaldehyde is a memory-related molecule in mice and humans
Authors: Ai Li , Tan Tao , Tang Yonghe , Yang Jun , Cui Dehua , Wang Rui , Wang Aibo , Fei Xuechao , Di Yalan , Wang Xiaoming , Yu Yan , Zhao Shengjie , Wang Weishan , Bai Shangying , Yang Xu , He Rongqiao , Lin Weiying , Han Hongbin , Cai Xiang , Tong Zhiqian 
Published: November 2019

AbstractGaseous formaldehyde is an organic small molecule formed in the early stages of earth’s evolution. Although toxic in high concentrations, formaldehyde plays an important role in cellular metabolism and, unexpectedly, is found even in the healthy brain. However, its pathophysiological functions in the brain are unknown. Here, we report that under physiological conditions, spatial learning activity elicits rapid formaldehyde generation from mitochondrial sarcosine dehydrogenase (SARDH). We find that elevated formaldehyde levels facilitate spatial memory formation by enhancing N-methyl-D-aspartate (NMDA) currents via the C232 residue of the NMDA receptor, but that high formaldehyde concentrations gradually inactivate the receptor by cross-linking NR1 subunits to NR2B. We also report that in mice with aldehyde dehydrogenase-2 (ALDH2) knockout, formaldehyde accumulation due to hypofunctional ALDH2 impairs memory, consistent with observations of Alzheimerʼs disease patients. We also find that formaldehyde deficiency caused by mutation of the mitochondrialSARDHgene in children with sarcosinemia or in mice withSardhdeletion leads to cognitive deficits. Hence, we conclude that endogenous formaldehyde regulates learning and memory via the NMDA receptor.
Harnessing energy landscape exploration to control the buckling of cylindrical shells
Authors: Panter J. R. , Chen J. , Zhang T. , Kusumaatmaja H. 
Published: November 2019

AbstractEven for relatively simple thin shell morphologies, many different buckled configurations can be stable simultaneously. Which state is observed in practice is highly sensitive to both environmental perturbations and shell imperfections. The complexity and unpredictability of postbuckling responses has therefore raised great challenges to emerging technologies exploiting buckling transitions. Here we show how the buckling landscapes can be explored through a comprehensive survey of the stable states and the transition mechanisms between them, which we demonstrate for cylindrical shells. This is achieved by combining a simple and versatile triangulated lattice model with efficient high-dimensional free-energy minimisation and transition path finding algorithms. We then introduce the method of landscape biasing to show how the landscapes can be exploited to exert control over the postbuckling response, and develop structures which are resistant to lateral perturbations. These methods now offer the potential for studying complex buckling phenomena on a range of elastic shells.
DNA methylation at the crossroads of gene and environment interactions
Authors: Law Pui-Pik , Holland Michelle L. 
Published: November 2019

Abstract
DNA methylation is an epigenetic mark involved in regulating genome function and is critical for normal development in mammals. It has been observed that the developmental environment can lead to permanent changes in gene expression and DNA methylation, at least at ‘metastable epialleles’. These are defined as regions of the genome that show a variable epigenetic state that is established early in development and maintained through subsequent cell divisions. However, the majority of the known genome does not behave in this manner. Here, we use the developmental origins of adult disease hypothesis to understand environmental epigenomics. Some challenges to studying how DNA methylation is influenced by the environment include identifying DNA methylation changes associated with an environmental exposure in tissues with a complex cellular composition and at genomic regions for which DNA methylation is dynamically regulated in a cell-type specific manner. We also offer a perspective of how emerging technologies may be useful for dissecting the functional contribution of exposure-associated epigenetic changes and highlight recent evidence that suggests that genomic regions that are absent from genome assemblies may be unappreciated hotspots for environmental modulation of the epigenetic state.
Dual input switched‐capacitor‐based single‐phase hybrid boost multilevel inverter topology with reduced number of components
Authors: Rawa Muhyaddin , Siddique Marif Daula , Mekhilef Saad , Mohamed Shah Noraisyah , Bassi Hussain , Seyedmahmoudian Mehdi , Horan Ben , Stojcevski Alex 
Published: November 2019

A new switched‐capacitor‐based topology with features of boosting and self‐voltage balancing of the capacitor has been proposed in this study. The proposed multilevel inverter topology uses two isolated dc voltage sources with a switched‐capacitor to produce 11 levels across the load. In this study, two different modes of the selection of dc voltage sources have been discussed for the proposed topology. Furthermore, the generalised structure of the proposed boost topology has also been discussed. Quantitative comparison with several topologies has been carried out to set the benchmark of the proposed topology. Selective harmonic elimination pulse width modulation technique has been adopted to improve the performance of the suggested topology. The power loss analysis of the proposed topology gives the maximum efficiency of 96.5% at the output power of 100 W and has an efficiency value of 95.3% at the output power of 500 W. The proposed topology has been simulated using PLECS and the simulation results have been verifying using an experimental prototype. The proposed topology has been tested for the different types of load and changes in the modulation index. The experimental results have verified the feasibility of the proposed topology.
Decoding the radial velocity variations of HD 41248 with ESPRESSO
Authors: Faria J. P. , Adibekyan V. , Amazo-Gómez E. M. , Barros S. C. C. , Camacho J. D. , Demangeon O. , Figueira P. , Mortier A. , Oshagh M. , Pepe F. , Santos N. C. , Gomes da Silva J. , Costa Silva A. R. , Sousa S. G. , Ulmer-Moll S. , Viana P. T. P. 
Published: November 2019

Context.Twenty-four years after the discoveries of the first exoplanets, the radial-velocity (RV) method is still one of the most productive techniques to detect and confirm exoplanets. But stellar magnetic activity can induce RV variations large enough to make it difficult to disentangle planet signals from the stellar noise. In this context, HD 41248 is an interesting planet-host candidate, with RV observations plagued by activity-induced signals.Aims.We report on ESPRESSO observations of HD 41248 and analyse them together with previous observations from HARPS with the goal of evaluating the presence of orbiting planets.Methods.Using different noise models within a general Bayesian framework designed for planet detection in RV data, we test the significance of the various signals present in the HD 41248 dataset. We use Gaussian processes as well as a first-order moving average component to try to correct for activity-induced signals. At the same time, we analyse photometry from the TESS mission, searching for transits and rotational modulation in the light curve.Results.The number of significantly detected Keplerian signals depends on the noise model employed, which can range from 0 with the Gaussian process model to 3 with a white noise model. We find that the Gaussian process alone can explain the RV data while allowing for the stellar rotation period and active region evolution timescale to be constrained. The rotation period estimated from the RVs agrees with the value determined from the TESS light curve.Conclusions.Based on the data that is currently available, we conclude that the RV variations of HD 41248 can be explained by stellar activity (using the Gaussian process model) in line with the evidence from activity indicators and the TESS photometry.
(704) Interamnia: a transitional object between a dwarf planet and a typical irregular-shaped minor body
Authors: Hanuš J. , Vernazza P. , Viikinkoski M. , Ferrais M. , Rambaux N. , Podlewska-Gaca E. , Drouard A. , Jorda L. , Jehin E. , Carry B. , Marsset M. , Marchis F. , Warner B. , Behrend R. , Asenjo V. , Berger N. , Bronikowska M. , Brothers T. , Charbonnel S. , Colazo C. , Coliac J.-F. , Duffard R. , Jones A. , Leroy A. , Marciniak A. , Melia R. , Molina D. , Nadolny J. , Person M. , Pejcha O. , Riemis H. , Shappee B. , Sobkowiak K. , Soldán F. , Suys D. , Szakats R. , Vantomme J. , Birlan M. , Berthier J. , Bartczak P. , Dumas C. , Dudziński G. , Ďurech J. , Castillo-Rogez J. , Cipriani F. , Fetick R. , Fusco T. , Grice J. , Kaasalainen M. , Kryszczynska A. , Lamy P. , Michalowski T. , Michel P. , Santana-Ros T. , Tanga P. , Vachier F. , Vigan A. , Witasse O. , Yang B. 
Published: November 2019

Context.With an estimated diameter in the 320–350 km range, (704) Interamnia is the fifth largest main belt asteroid and one of the few bodies that fills the gap in size between the four largest bodies withD> 400 km (Ceres, Vesta, Pallas and Hygiea) and the numerous smaller bodies with diameter ≤200 km. However, despite its large size, little is known about the shape and spin state of Interamnia and, therefore, about its bulk composition and past collisional evolution.Aims.We aimed to test at what size and mass the shape of a small body departs from a nearly ellipsoidal equilibrium shape (as observed in the case of the four largest asteroids) to an irregular shape as routinely observed in the case of smaller (D≤ 200 km) bodies.Methods.We observed Interamnia as part of our ESO VLT/SPHERE large program (ID: 199.C-0074) at thirteen different epochs. In addition, several new optical lightcurves were recorded. These data, along with stellar occultation data from the literature, were fed to the All-Data Asteroid Modeling algorithm to reconstruct the 3D-shape model of Interamnia and to determine its spin state.Results.Interamnia’s volume-equivalent diameter of 332 ± 6 km implies a bulk density ofρ= 1.98 ± 0.68 g cm−3, which suggests that Interamnia – like Ceres and Hygiea – contains a high fraction of water ice, consistent with the paucity of apparent craters. Our observations reveal a shape that can be well approximated by an ellipsoid, and that is compatible with a fluid hydrostatic equilibrium at the 2σlevel.Conclusions.The rather regular shape of Interamnia implies that the size and mass limit, under which the shapes of minor bodies with a high amount of water ice in the subsurface become irregular, has to be searched among smaller (D≤ 300 km) less massive (m≤ 3 × 1019kg) bodies.
Spécificités d’un protocole chirurgico-orthodontique par Clear Aligner Therapy
Authors: Daouri Amine , Asselborn Marc , Majoufre Claire , Gleizal Arnaud , Makaremi Masrour 
Published: November 2019

Depuis l’avènement de la Clear Aligner Therapy (CAT) introduit par Invisalign en 1998, seulement quelques articles ont abordé le traitement combinant chirurgie orthognathique et Clear Aligner Therapy mais il ne s’agissait que de case-report pour la plupart. L’objectif de cet article était donc de présenter et de proposer un protocole orthodontico-chirurgical dans le cadre de dysmorphies maxillo-mandibulaires préparées par Clear Aligner Therapy et requérant une chirurgie orthognathique.
Nous avons recueillis l’expérience de nombreux orthodontistes possédant une expérience importante dans le domaine de la Clear Aligner Therapy et notamment dans la préparation de cas chirurgicaux.
Nous avons donc établi un protocole en 17 étapes avec de nombreuses astuces pour mener à bien ces traitements : de l’examen clinique initial par l’orthodontiste et le chirurgien maxillo-facial jusqu’à la phase de contention finale avec la symbiose orthodontico-chirurgicale placée au centre du projet thérapeutique.
Nous avons associé à ce protocole une revue de la littérature concernant la phase de blocage maxillo-mandibulaire per-opératoire (par fils d’acier) et postopératoire (par élastiques) : périodes clés dans la gestion du traitement orthodontico-chirurgicale
Lunge in Not
Authors: Knauber-Idler Gabriele 
Published: November 2019

SummaryTypische COPD-Symptome wie chronischer Husten und Luftnot können auch andere Ursachen wie Asthma bronchiale haben und müssen diagnostisch abgeklärt werden. COPD ist teilweise irreversibel, betrifft in Deutschland 13% der über 40-Jährigen, geht mit einer chronisch-obstruktiven Bronchitis einher und mündet oft in ein – letztlich lebensbedrohliches – Lungenemphysem. Eine frühe und gründliche Diagnostik sowie eine individuell angepasste Behandlung mit Sympathomimetika, Kortisonderivaten, Rauchstopp, Bewegungstherapie und Atemtraining können die Lungenfunktion verbessern und den Zustand stabilisieren.