bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myopathic changes associated with psychomotor delay and seizures caused by a novel homozygous mutation in TBCK
Authors: Saredi Simona , Cauley Edmund S. , Ruggieri Alessandra , Spivey Tyler M. , Ardissone Anna , Mora Marina , Moroni Isabella , Manzini M. Chiara 
Published: May 2020

AbstractBackgroundBiallelic mutations in TBC1‐domain containing kinase (TBCK) lead to hypotonia, global developmental delay with severe cognitive and motor deficits, and variable presentation of dysmorphic facial features and brain malformations. It remains unclear whether hypotonia in these individuals is purely neurogenic, or also caused by progressive muscle disease.MethodsWhole exome sequencing was performed on a family diagnosed with nonspecific myopathic changes by means of histological analysis and immunohistochemistry of muscle biopsy samples.ResultsA novel homozygous truncation in TBCK was found in two sisters diagnosed with muscle disease and severe psychomotor delay. TBCK was completely absent in these patients.ConclusionsOur findings identify a novel early truncating variant in TBCK associated with a severe presentation and add muscle disease to the variability of phenotypes associated with TBCK mutations. Inconsistent genotype/phenotype correlation could be ascribed to the multiple roles of TBCK in intracellular signaling and endolysosomal function in different tissues.
Spectral analysis of Pk Finite Element matrices in the case of Friedrichs–Keller triangulations via Generalized Locally Toeplitz technology
Authors: Rahla Ryma Imene , Serra‐Capizzano Stefano , Tablino‐Possio Cristina 
Published: May 2020

SummaryIn the present article, we consider a class of elliptic partial differential equations with Dirichlet boundary conditions and where the operator is
div(−a(x)∇·), with a continuous and positive over , Ω being an open and bounded subset of , d≥1. For the numerical approximation, we consider the classical Finite Elements, in the case of Friedrichs–Keller triangulations, leading, as usual, to sequences of matrices of increasing size. The new results concern the spectral analysis of the resulting matrix‐sequences in the direction of the global distribution in the Weyl sense, with a concise overview on localization, clustering, extremal eigenvalues, and asymptotic conditioning. We study in detail the case of constant coefficients on Ω=(0,1)2 and we give a brief account in the more involved case of variable coefficients and more general domains. Tools are drawn from the Toeplitz technology and from the rather new theory of Generalized Locally Toeplitz sequences. Numerical results are shown for a practical evidence of the theoretical findings.
Liquid‐Phase Quasi‐Epitaxial Growth of Highly Stable, Monolithic UiO‐66‐NH2 MOF thin Films on Solid Substrates
Authors: Hashem Tawheed , Valadez Sánchez Elvia P. , Weidler Peter G. , Gliemann Hartmut , Alkordi Mohamed H. , Wöll Christof 
Published: May 2020

AbstractInvited for this month's cover is the group of Dr. Tawheed Hashem from the Karlsruhe Institute of Technology. The cover picture shows a successful synthesis of high quality, monolithic UiO‐66‐NH2 MOF thin films on diverse solid substrates via a low‐temperature liquid phase epitaxy method. The achievement of continuous MOF‐coatings with low defect densities and pronounced stability against high temperatures and hot water was proven. The new type of coatings clearly outperforms other reported types of MOF thin films. Read the full text of their Communication at 10.1002/open.201900324.
Medication persistence of targeted immunomodulators for plaque psoriasis: A retrospective analysis using a U.S. claims database
Authors: Hendrix Nathaniel , Marcum Zachary A. , Veenstra David L. 
Published: May 2020

AbstractPurposeStudies of medication persistence in plaque psoriasis have shown inconsistent results, likely due to differing definitions of nonpersistence and of the permissible gap between refills. Also, medication persistence information for two recently approved drugs, apremilast and ixekizumab, is limited.MethodsWe use the Truven Health MarketScan claims database to assess persistence for six drugs: adalimumab, apremilast, etanercept, ixekizumab, secukinumab, and ustekinumab. We define the permissible gap in three ways: 150 days for ustekinumab and 90 days for all other drugs (150/90 model); 120 days for all drugs (120 model); and twice the days' supply for all drugs (days' supply model). To estimate unadjusted persistence, we use Kaplan‐Meier curves, and a proportional hazards model to estimate the adjusted risk of non‐persistence.ResultsUstekinumab is most sensitive to changes in the definition of permissible gap, likely because of its longer maintenance dosing interval. Among targeted drug‐experienced patients using ustekinumab, median persistence is 358 days (95% confidence interval: 343‐371) in the 150/90 model and 189 days (179‐199) in the days' supply model. Among targeted drug‐experienced patients, median persistence in the days' supply model is longest for ixekizumab and secukinumab at 252 (217‐301) and 222 (210‐244) days, respectively. We also find that adjusted risk of nonpersistence increases by approximately 1% per year at treatment start.ConclusionThe definition of permissible gap meaningfully changes both absolute and ordinal estimates of medication persistence. Each definition has unique limitations, which should be considered when interpreting persistence data.
Doppeltes Drehspiel
Authors: Ucke Christian , Schlichting Hans Joachim 
Published: May 2020

ZusammenfassungBeim Karussellkreisel‐Spielzeug hängen zwei magnetisch gehaltene Kreisel symmetrisch an einer Haltestange, die mit den Kreiseln um eine Lagerung in der Mitte rotieren kann. Die in gleicher Richtung angedrehten Kreisel üben ein kleines Reibdrehmoment bezüglich der Drehachse in der Mitte aus. So versetzen sie die Haltestange ebenfalls zunehmend in Drehung. Das ungewöhnliche Spielzeug verleitet zu weiteren Experimenten.
Young adult cancer caregivers' use of social media for social support
Authors: Warner Echo L. , Kirchhoff Anne C. , Ellington Lee , Waters Austin R. , Sun Ye , Wilson Andrew , Cloyes Kristin G. 
Published: May 2020

AbstractObjectiveTo describe how young adult cancer caregivers (YACC) use social media for social support during a cancer experience.MethodsEligible YACC were 18 to 39 years, used Facebook and/or Instagram at least once per week, and cared for an adult cancer patient diagnosed 6 months to 5 years prior (N = 34). Recruitment of a cross‐sectional sample occurred through oncology clinics in Utah and online advertising by caregiving and cancer organizations from September 2017 to June 2018. Semi‐structured telephone interviews were recorded, transcribed, iteratively coded, and qualitatively analyzed, yielding four categories concerning how YACC use social media.ResultsCaregivers were most commonly spouses aged 29 years on average (range 21‐38); cancer patients were 37 years (range 19‐76). Analysis yielded four distinct yet related categories: Category 1: Posting about cancer on social media often begins as a strategy for YACC to efficiently provide updates about the cancer patient. Category 2: Caregivers who actively post on social media experience a variety of different functional social supports to which they otherwise would not have access. Category 3: Posting about cancer online presents an opportunity for negative consequences. Category 4: Potential for negative consequences influences how some caregivers use social media.ConclusionsSupportive services, including social media‐based supports, are needed for YACC in formats that are convenient for them as they balance their caretaking duties with their daily lives.
Clinical features and accompanying findings of Pseudo‐Bartter Syndrome in cystic fibrosis
Authors: Sismanlar Eyuboglu Tugba , Dogru Deniz , Çakır Erkan , Cobanoglu Nazan , Pekcan Sevgi , Cinel Guzin , Yalçın Ebru , Kiper Nural , Sen Velat , Selimoglu Sen Hadice , Ercan Omur , Keskin Ozlem , Bilgic Eltan Sevgi , Alshadfan Lina , Yazan Hakan , Altıntas Derya Ufuk , Sasihuseyinoglu Ayse Senay , Sapan Nihat , Cekic Sükrü , Cokugraş Haluk , Kılınc Ayşe Ayzıt , Ramaslı Gursoy Tugba , Aslan Ayse Tana , Bingol Aysen , Başaran Abdurrahman Erdem , Ozdemir Ali , Kose Mehmet , Hangul Melih , Emiralioglu Nagehan , Tugcu Gokçen , Yuksel Hasan , Yılmaz Ozge , Orhan Fazıl , Gayretli Aydın Zeynep Gokce , Topal Erdem , Tamay Zeynep , Suleyman Ayse , Can Demet , Bal Cem Murat , Caltepe Gönül , Ozcelik Uğur 
Published: May 2020

AbstractBackgroundPseudo‐Bartter syndrome (PBS) is a rare complication of cystic fibrosis (CF) and there are limited data in the literature about it. We aimed to compare clinical features and accompanying findings of patients with PBS in a large patient population.MethodsThe data were collected from the Cystic Fibrosis Registry of Turkey where 1170 CF patients were recorded in 2017. Clinical features, diagnostic test results, colonization status, complications, and genetic test results were compared in patients with and without PBS.ResultsTotally 1170 patients were recorded into the registry in 2017 and 120 (10%) of them had PBS. The mean age of diagnosis and current age of patients were significantly younger and newborn screening positivity was lower in patients with PBS (P < .001). There were no differences between the groups in terms of colonization status, mean z‐scores of weight, height, BMI, and mean FEV1 percentage. Types of genetic mutations did not differ between the two groups. Accompanying complications were more frequent in patients without PBS.ConclusionPBS was detected as the most common complication in the registry. It could be due to warm weather conditions of our country. It is usually seen in younger ages regardless of mutation phenotype and it could be a clue for early diagnosis of CF.
Comparing wavelet and Fourier perspectives on the decomposition of meridional energy transport into synoptic and planetary components
Authors: Heiskanen Tuomas , Graversen Rune Grand , Rydsaa Johanne Hope , Isachsen Pål Erik 
Published: May 2020

AbstractThe Arctic region shows some of the world's most significant signs of climate change; for instance, a negative trend in summer sea‐ice cover of around 15% per decade and Arctic amplified surface‐air warming that is three times the global average. The atmospheric energy transport plays an important role in the Arctic climate. Recently a Fourier‐based method for studying the atmospheric energy transport contribution by planetary‐ and synoptic‐scale waves has been proposed. Recent studies based on this method show that planetary waves contribute more than synoptic waves to the atmospheric energy transport into the Arctic. However, this Fourier method suffers from being incapable of resolving spatially localized systems such as cyclones. Here an attempt to evaluate this problem is presented by applying the method on synthetic and reanalysis data. In addition, an alternative method based on a wavelet decomposition is proposed and compared with the Fourier‐based method. The wavelet method is based on localized basis functions which should be capable of resolving these localized systems. The wavelet method shows an impact of synoptic‐scale transport on Arctic temperatures which is not captured by the Fourier method, whilst the planetary‐scale effect of both methods appears similar.
C−C and C−S Coupling Catalyzed by Supported Cu(II) on Nano CoFe2O4
Authors: Tamoradi Taiebeh , Masoumeh Mousavi Seyedeh , Mohammadi Masoud 
Published: May 2020

AbstractA new magnetically recoverable copper nanocatalyst was readily prepared and structurally characterized by FT‐IR, SEM, EDX, X‐ray map and XRD techniques. The prepared nanocatalyst exhibited efficient catalytic activity in C−C and C−S coupling reactions. The catalyst can be magnetically recovered after the reaction and can be reused for five times without appreciable decrease in activity.
Enhancement in Photovoltaic Properties of N,N‐diethylaniline based Donor Materials by Bridging Core Modifications for Efficient Solar Cells
Authors: Hussain Riaz , Khan Muhammad Usman , Mehboob Muhammad Yasir , Khalid Muhammad , Iqbal Javed , Ayub Khurshid , Adnan Muhammad , Ahmed Mahmood , Atiq Kainat , Mahmood Khalid 
Published: May 2020

AbstractThe increasing demand of energy expedited the development of efficient photovoltaic materials.Herein, five push‐pull donor materials (D1‐D5) having N,N‐diethylaniline as donor moiety and rhodanine‐3‐acetic as acceptor group are designed to be used as donor molecules in organic solar cells (OSCs). The bridging core modification of recently synthesized MR3 molecule (reference R) has been made with different π‐spacers namely thiazole (B1), thieno[3,2‐b]thiophene (B2), thiazolo[5,4‐d] thiazole (B3), 2‐(thiophen‐2‐yl)thiophene (B4) and 5‐(thiazol‐5yl)thiazole (B5). The structure–property relationship is studied and influence of bridging core modifications on photovoltaic, photophysical and electronic properties of D1‐D5 are calculated and compared with reference R.The DFT and TDDFT calculations have been performed for the estimation of frontier molecular orbital (FMO) analysis, density of states (DOS) graphs, reorganization energies of electron and hole, open circuit voltage, photophysical characteristics, transition density matrix (TDM) surfaces and charge transfer analysis.Designed molecules exhibit better and comparable optoelectronic properties than synthesized reference molecules. Among all investigated molecules, D5 is proven as best candidate for OSCs application due to its promising photovoltaic properties including lowest band gap (2.24 eV), small electron mobility (λe=0.0056 eV), small hole mobility (λh=0.0046 eV), low binding energy (Eb=0.21 eV), highest λmax values 610.76 nm (in gas) 670.22 nm (in acetonitrile) and high open circuit voltage (Voc=1.17 V) with respect to HOMOdonor–LUMOPC61BM. This theoretical framework demonstrates that bridging core modification is a simple and effective alternative strategy to achieve the desirable optoelectronic properties. Furthermore, conceptualized molecules are superior and thus are recommended to experimentalist for out‐looking future developments of highly efficient solar cells.
High Virus Removal by Self‐Organized Nanostructured 2D Liquid‐Crystalline Smectic Membranes for Water Treatment
Authors: Kuo Daniel , Liu Miaomiao , Kumar K. R. Sunil , Hamaguchi Kazuma , Gan Kian Ping , Sakamoto Takeshi , Ogawa Takafumi , Kato Riki , Miyamoto Nobuyoshi , Nada Hiroki , Kimura Masahiro , Henmi Masahiro , Katayama Hiroyuki , Kato Takashi 
Published: May 2020

AbstractTo obtain high quality of drinking water free from biocontaminants is especially important issue. A new strategy employing smectic liquid‐crystalline ionic membranes exhibiting 2D structures of layered nanochannels for water treatment is proposed for efficient virus removal and sufficient water flux. The smectic A (SmA) liquid‐crystalline membranes obtained by in situ polymerization of an ionic mesogenic monomer are examined for removal of three distinct viruses with small size: Qβ bacteriophage, MS2 bacteriophage, and Aichi virus. The semi‐bilayer structure of the SmA significantly obstructs the virus penetration with an average log reduction value of 7.3 log10 or the equivalent of reducing 18 million viruses down to 1. Furthermore, the layered nanochannels of the SmA liquid crystal allow efficient water permeation compared to other types of liquid‐crystalline membrane consisting of nanopores.
Quality by design with design of experiments approach for the development of a stability‐indicating LC method for benzonatate and its impurities in liquid oral dosage form
Authors: Katakam Lakshmi Narasimha Rao , Dongala Thirupathi 
Published: May 2020

AbstractA quality by design based simple and stability‐indicating liquid chromatography method has been developed successfully for benzonatate and its related impurities. The optimized high‐performance liquid chromatography method can be used to detect and quantify the benzonatate impurities in its finished liquid oral dosage forms. For the quantification of impurities demands more comprehensive way of analytical method development. Quality by design approach allows the assessment of various analytical parameters and their effects with minimum number of experiments. The current method has been separated five specified known impurities of benzonatate along with unspecified degradation products with adequate chromatographic resolution. The separation was acquired by using Zorbax SB CN, (4.6 × 250 mm), 5 μm column at a flow rate of 0.9 mL/min with a gradient elution mode. Mobile phase A consisting of 15 mM monobasic potassium phosphate (pH of 2.7) and tetrahydrofuran (90:10 v/v) and mobile phase B was mixture of acetonitrile and tetrahydrofuran (90:10 v/v). Detection of compounds was carried out at 310 nm and column temperature was maintained at 35°C. The drug product and drug substance were subjected to the stress conditions such as acid, base, oxidation, heat, and photolysis as per the recommendations of International Conference on Harmonization (Q2) methodology. The method was validated to be precise, specific, robust, rugged, and stability indicating.
In ovo inoculation of duck embryos with different strains of Bacillus cereus to analyse their synergistic post‐hatch anti‐allergic potentialities
Authors: Al Azad Salauddin , Moazzem Hossain Khondoker , Rahman Sana Mohammad Mahbubur , Al Mazid Mohammad Faysal , Barai Pallob , Gazi Mohammad Shamim 
Published: May 2020

AbstractBackgroundBacillus cereus is a Gram‐positive, facultative anaerobic bacteria with few strains reported to be used as probiotics for animals and birds in recent times if the doses are formulated properly.ObjectivesTo analyse the synergistic anti‐allergic potentiality of different Bacillus cereus strains on experimental in ovo and in vitro duck model, as probiotic immune stimulant.Materials and methodsDifferent strains of Bacillus cereus from 29 isolates were identified through 16S rRNA gene sequencing from the milk samples of buffalo breeds of South Asia. The probiotic properties were tested in aspects of gram staining, catalase test, coagulase, test, bile salt tolerance, pH tolerance and phenol tolerance test. MIC50 and MIC90 levels were profiled using nine different antibiotics, and antimicrobial activity against eight different enteric pathogens was assessed. Finally, the test strains of Bacillus cereus (Colony Forming Unit [CFU] 30X1011) were combined‐infused at different concentrations in embryonated duck eggs to assess the post‐hatch anti‐allergic effects against histamine‐induced allergic reaction and their immunoglobulin E (IgE) level was tested.ResultsMolecular identification confirmed the test strains as B. cereus HKS 1–1, B. cereus LOCK 1,002 and B. cereus BF2, which were all motile, spore‐forming, catalase‐positive and rod‐shaped. All were 0.3% bile salt, 0.4% phenol and pH tolerant. Two‐way ANOVA test P values revealed that B. cereus BF2 was statistically significant (p < .0014) in bile salt tolerance test. B. cereus HKS 1–1 was significant in phenol and pH tolerance at p < .0002 and p < .0489, respectively. Besides, the test strains showed antibiotic sensitivity and antimicrobial activity to different enteric pathogens. In vivo model referred the test strains as effective in partial allergy reduction at same CFU but at different concentrations with p < .0001 among the groups.ConclusionThe isolated and characterized strains of B. cereus showed partial immune‐stimulating potentiality against experimentally induced allergic reaction.
Rational CFT with three characters: the quasi-character approach
Authors: Mukhi Sunil , Poddar Rahul , Singh Palash 
Published: May 2020

AbstractQuasi-characters are vector-valued modular functions having an integral, but not necessarily positive, q-expansion. Using modular differential equations, a complete classification has been provided in arXiv:1810.09472 for the case of two characters. These in turn generate all possible admissible characters, of arbitrary Wronskian index, in order two. Here we initiate a study of the three-character case. We conjecture several infinite families of quasi-characters and show in examples that their linear combinations can generate admissible characters with arbitrarily large Wronskian index. The structure is completely different from the order two case, and the novel coset construction of arXiv:1602.01022 plays a key role in discovering the appropriate families. Using even unimodular lattices, we construct some explicit three-character CFT corresponding to the new admissible characters.
A graphic approach to identities induced from multi-trace Einstein-Yang-Mills amplitudes
Authors: Du Yi-Jian , Hou Linghui 
Published: May 2020

AbstractSymmetries of Einstein-Yang-Mills (EYM) amplitudes, together with the recursive expansions, induce nontrivial identities for pure Yang-Mills amplitudes. In the previous work [1], we have already proven that the identities induced from tree level single-trace EYM amplitudes can be precisely expanded in terms of BCJ relations. In this paper, we extend the discussions to those identities induced from all tree level multi-trace EYM amplitudes. Particularly, we establish a refined graphic rule for multi-trace EYM amplitudes and then show that the induced identities can be fully decomposed in terms of BCJ relations.
Quadriceps tendon autograft for primary ACL reconstruction: a Bayesian network meta-analysis
Authors: Migliorini Filippo , Eschweiler Jörg , Mansy Yasser El , Quack Valentin , Tingart Markus , Driessen Arne 
Published: May 2020

AbstractBackgroundThe purpose of the current study was to clarify the role of the quadriceps tendon (QT) autograft for primary ACL reconstruction. Thus, a Bayesian network meta-analysis comparing patients undergoing a primary ACL reconstruction with QT versus patellar tendon (PT) and hamstring tendon (HT) autografts was conducted.Material and methodsThis Bayesian network meta-analysis was conducted according to the PRISMA extension statement for reporting systematic reviews incorporating network meta-analyses of health care interventions. In January 2020, the main databases were accessed. Articles comparing the outcomes of the QT autograft versus HT autograft and/or PT autograft for primary ACL reconstruction were included in the present study. The statistical analysis was performed with STATA Software/MP, through a Bayesian hierarchical random-effect model analysis.ResultsData from a total of 2603 knees were analysed. The overall mean follow-up was 35.0 months. Among the different grafts were evidenced comparable values of IKDC, Tegner and Lysholm score. The QT autograft detected comparable rate of Lachman test > 3 mm, Pivot shift test > 3 m and instrumental laxity > 3 mm. The QT autograft showed a lower rate of autograft failure above all. The QT autograft detected the reduced rate of AKP than the PT.ConclusionQuadriceps tendon autograft may represent a feasible option for primary ACL reconstruction. These results must be interpret within the limitations of the present network meta-anlaysis.