bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Trajectories of Post-Election Distress Track Changes in Neural and Psychological Functioning
Authors: Tashjian Sarah M. , Galván Adriana 
Published: February 2020

Abstract
The shift in political climate after the 2016 U.S. presidential election had a distressing effect on many individuals. To date, no research has identified how changes in societal-level distressing experiences affected ongoing neurobiological and psychological functioning. Fifty-five participants (Mage = 21.746, 37 women) were tested at two time points. fMRI and psychological measures were used to test the hypotheses that increases in distress over 1 year would relate to worsening mental health symptomology and blunted neurobiological response to reward during the same period. Because individual experiences of distress occurred within a larger macroclimate of societal attitudes, measures were standardized to reflect relative change within the sample. Distress changes over 1 year were positively associated with problematic mental health symptomology and nucleus accumbens (NAcc) response to reward, with dissociable effects for anticipation and outcome. Worsening distress was associated with increased NAcc response to reward anticipation but decreased NAcc response to reward outcome. Individuals who exhibited increased sensitivity to anticipatory reward were those who exhibited more avoidance distress symptoms, whereas intrusion and hyperarousal were associated with decreased sensitivity to reward outcome. This study highlights the importance of considering individual variation in profiles of change in response to ongoing distress, suggests that individual response styles yield differences in reward sensitivity, and extends neurobiological understanding of exposure to stressful life experiences to political events.
‘Seek that Radiance which Sanāʾī Expounded, that Unique One whose Uniqueness ʿAṭṭār Revealed’: Decoding a Verse of Sanāʾī through Rūmī’s Works, and a Verse of Rūmī through His Quotation of ʿAṭṭār
Authors: Moqaddam Sassan Zand , Nourian Mehdi 
Published: February 2020

AbstractThis article suggests new readings for two controversial lines of Persian mystical literature, and is divided into two parts. Part one concerns a line of Sanāʾī (d. 525/1131) in his Ḥadīqat al-ḥaqīqat: ‘Sūfīs undergo two festivals in a moment, while spiders make jerky out of flies.’ We present an interpretation for this enigmatic statement by an intertextual reading of lines by Mawlānā Jalāl al-Dīn Rūmī (d. 672/1273), which arguably constitute subtle commentaries on Sanāʾī’s works. In Part two, we propose that the doctrine of the ‘Changing of Temperaments’ can help explain the notion of ‘spiritual food’. Part three examines the following line in Rūmī’s Mathnawī: ‘Every druggist (‛aṭṭār) whose intellect became acquainted with Him dropped the trays into the water of the river.’ We argue that this line subtly alludes to a controversial ghazal of Farīd al-Dīn ‛Aṭṭār (d. 618/1221), which can provide a new symbolic key to understanding the somewhat obscure meaning of certain words in this line. As the title of this article, taken from a line in the Kulliyyāt-i Shams, suggests, Rūmī clearly and repeatedly acknowledges the influence of ‛Aṭṭār and Sanāʾī on his work. Using an intertextual interpretive method and a close reading of the works of Rūmī, Sanāʾī, and ‛Aṭṭār, we propose new interpretations of the lines in question that are more homogeneous with the text of the Mathnawī.
Implementación del Modelo Islandés para la Prevención del Uso del Sustancias en Adolescentes
Authors: Kristjansson Alfgeir L. , Mann Michael J. , Sigfusson Jon , Thorisdottir Ingibjorg E. , Allegrante John P. , Sigfusdottir Inga Dora 
Published: February 2020

Resumen Esta es la segunda de una serie de dos partes de artículos sobre el Modelo Islandés de Prevención Primaria del Uso de Sustancias (MIP) en Health Promotion Practice. El MIP es una estrategia comunitaria colaborativa que ha demostrado notable efectividad en reducir el inicio del uso de sustancias entres jóvenes de Islandia en los últimos 20 años. Mientras el primer artículo se enfocó en el contexto de fondo, orientación teórica, evaluación y evidencia de su efectividad, y los cinco principios guías del modelo, este segundo artículo describe los 10 pasos centrales en la implementación práctica. Los pasos 1 a 3 se enfocan en cómo construir y mantener la capacidad comunitaria para la implementación del modelo. Los pasos 4 a 6 se enfocan en cómo implementar un sistema riguroso de recolección de datos, como procesarlos, la diseminación de los datos y la traducción de los hallazgos. Los pasos 7 a 9 están diseñados para enfocar la atención de la comunidad y para maximizar el compromiso comunitario en crear y mantener un medioambiente social en el cual la gente joven progresivamente se hace menos proclive a consumir sustancias, e incluye ejemplos ilustrativos de Islandia. Y el paso 10 se enfoca en la naturaleza iterativa, repetitiva y de largo plazo del MIP y describe un amplio y predecible arco de oportunidades y desafíos relacionados con la implementación. Este artículo concluye con una breve discusión sobre las potenciales variaciones en los factores comunitarios para la implementación.
Sleep duration and risk of cardiovascular events: The SAVE study
Authors: Li Jingwei , Zheng Danni , Loffler Kelly A , Wang Xia , McEvoy R Doug , Woodman Richard J , Luo Yuanming , Lorenzi-Filho Geraldo , Barbe Ferran , Tripathi Manjari , Anderson Craig S ,   for the SAVE Investigators
Published: February 2020

Background and aim Controversy exists regarding cardiovascular risk in relation to sleep duration. We determined sleep duration and major recurrent cardiovascular event associations in patients with obstructive sleep apnoea and established cardiovascular disease. Methods Secondary analyses of the international, multicenter, Sleep Apnea Cardiovascular Endpoints trial. Sleep duration was estimated from overnight home oximetry (ApneaLink monitor) used for obstructive sleep apnoea diagnosis. Cox proportional hazards models were used to determine associations of categorized sleep duration (<6 h, 6–8 h (reference), and >8 h) and major cardiovascular outcomes: primary composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and any hospitalization for unstable angina, heart failure, or transient ischemic attack; secondary composite of cardiac and cerebral (stroke/transient ischemic attack) events. Results Oximetry-derived sleep duration estimates were available in 2687 participants (mean 61.2 years, 80.9% males) who experienced a total of 436 cardiovascular events over a mean follow-up of 3.7 years. Compared to the reference category, sleep duration was not associated with risk of the primary composite cardiovascular outcome (adjusted hazard ratio (HR) 1.00, 95% confidence interval 0.76–1.33, and HR 1.22, 95% confidence interval 0.98–1.52, for sleep duration <6 and >8 h, respectively). However, long sleep was associated with increased cerebral events (HR 1.67, 95% confidence interval 1.17–2.39; P = 0.005) and stroke alone (HR 1.79, 95% confidence interval 1.22–2.63; P = 0.003). Conclusions Long sleep duration is associated with an increased risk of stroke but not cardiac events in obstructive sleep apnoea patients with existing cardiovascular disease. Clinical trial registration The trial is registered at ClinicalTrials.gov (NCT00738179).
Cardiovascular event rates increase after each recurrence and associate with poor statin adherence
Authors: Lassenius Mariann I , Toppila Iiro , Bergius Susanne , Perttilä Julia , Airaksinen K E Juhani , Pietilä Mikko 
Published: February 2020

Abstract

Aims
The study evaluated the quality of cardiovascular prevention in real-world clinical practice. The recurrence of up to five cardiovascular events was assessed, as data on recurrence beyond the first event and interindividual variations in event rates past the second event have been sparse. Low-density lipoprotein cholesterol concentrations and lipid-lowering therapy use were investigated.

Methods
This retrospective register-based study included adult patients with an incident cardiovascular event between 2004 and 2016 treated in the hospital district of southwest Finland. Patients were followed for consecutive cardiovascular events or cardiovascular death, low-density lipoprotein cholesterol and statin purchases. The timing of event recurrence was evaluated, and predictive factors were assessed.

Results
A wide interindividual variation in cardiovascular event recurrence was observed, each additional event caused an increased risk, the median time of recurrence decreased from 7 to one year for the second and fifth event. Event rates increased correspondingly from 12 to 43/100 patient-years and were most pronounced in the first years following the previous event. The low-density lipoprotein cholesterol goal (&lt;1.8 mmol/l) was reached by 18% in the year after the event and statin underuse was associated with an increased risk of recurrence. Six months after the index event high intensity statins were used by only 22% of the cohort.

Conclusion
The study provides new perspectives on individual risk assessment showing that event rates are not stable for all patients but increase 1.2–1.9-fold per consecutive event. The underuse of statins and poor adherence support the identification of these patients for intensified multifactorial preventive measures.
Diagnosis of insulinoma in a Maine Coon cat
Authors: Gifford Carol H , Morris Anita P , Kenney Kurt J , Estep J Scot 
Published: February 2020

Case summary A 9-year-old male neutered Maine Coon cat presented with a 6-month history of polyphagia and one recent episode of tremors and weakness. Blood work revealed profound hypoglycemia and results of a paired insulin glucose test were consistent with an insulinoma. Abdominal ultrasound revealed a solitary pancreatic mass, and results of a fine-needle aspirate (FNA) gave further support for the location of the neuroendocrine tumor. After unsuccessful medical management of the hypoglycemia, the mass was surgically removed. Immunohistochemistry confirmed that it was an insulinoma. At the time of writing, the patient had been in clinical remission for 9 months. Relevance and novel information Feline insulinomas are rare and there is very little information on their behavior, clinical course and histologic characteristics. This is the first reported case of an insulinoma in a Maine Coon cat and the first to describe results of an ultrasound-guided FNA of the mass. In addition, the progression of disease, histopathology and immunohistochemistry results add to the currently minimal database for feline insulinomas.
The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp.-Q67
Authors: Xu Ya-Qian , Li Kai , Wang Ze-Jun , Liu Shu-Shen 
Published: February 2020

AbstractBackgroundThe weak magnetic field (WMF) can enhance the ability to remove target pollutants in wastewater, which drives us to consider whether WMF could give rise to the hormesis or not. In our previous study, it was found that polymyxin B sulfate (POL) can induce weak hormesis onVibrio qinghaiensissp.-Q67 (Q67). To this end, we set up four different WMF treatments during Q67 culture and POL exposure process, having no WMF in all cases (NW), adding WMF all the time (AW), exerting WMF only during the bacterial culture (BW), and exerting WMF only in POL exposure period (EW).ResultsIt was shown that the concentration–response curves (CRCs) of POL in four WMF treatments at the exposure times of 6, 9, and 12 h are non-monotonic hormetic curves where the maximum stimulative effects (Emin) of POL in BW and EW are obviously larger than those in AW and NW. The maximumEminis 26.8% occurring in EW and 20.7% in BW at 6 h, while the maxEminis 14.6% in NW at 9 h, it means that stimulations of POL in BW and EW are earlier and stronger than those in NW. These findings first indicated that WMF can enhance the hormesis of POL.ConclusionsThis study showed that WMF as a key factor may influence the maximum stimulation effect of hormesis. The characteristic of biphasic (hormetic effect) challenges the traditional classical threshold model that is close to chemical risk assessment. But the mechanism of hormesis even now is inconclusive. WMF as a novelty and neglected factor has the potential to support the further development of hormesis mechanism.
Correction to: Comparative genomics of Alternaria species provides insights into the pathogenic lifestyle of Alternaria brassicae – a pathogen of the Brassicaceae family
Authors: Rajarammohan Sivasubramanian , Paritosh Kumar , Pental Deepak , Kaur Jagreet 
Published: February 2020

Following the publication of this article [1], the authors reported that the captions of Figs. 2 and 3 were published in the incorrect order, whereby they mismatch with their corresponding images. The figures are reproduced in the correct sequence with the correct captions in this Correction article. The original article has been corrected.
Genomic analysis of Spanish wheat landraces reveals their variability and potential for breeding
Authors: Pascual Laura , Ruiz Magdalena , López-Fernández Matilde , Pérez-Peña Helena , Benavente Elena , Vázquez José Francisco , Sansaloni Carolina , Giraldo Patricia 
Published: February 2020

Abstract
Background
One of the main goals of the plant breeding in the twenty-first century is the development of crop cultivars that can maintain current yields in unfavorable environments. Landraces that have been grown under varying local conditions include genetic diversity that will be essential to achieve this objective. The Center of Plant Genetic Resources of the Spanish Institute for Agriculture Research maintains a broad collection of wheat landraces. These accessions, which are locally adapted to diverse eco-climatic conditions, represent highly valuable materials for breeding. However, their efficient use requires an exhaustive genetic characterization. The overall aim of this study was to assess the diversity and population structure of a selected set of 380 Spanish landraces and 52 reference varieties of bread and durum wheat by high-throughput genotyping.

Results
The DArTseq GBS approach generated 10 K SNPs and 40 K high-quality DArT markers, which were located against the currently available bread and durum wheat reference genomes. The markers with known locations were distributed across all chromosomes with relatively well-balanced genome-wide coverage. The genetic analysis showed that the Spanish wheat landraces were clustered in different groups, thus representing genetic pools providing a range of allelic variation. The subspecies had a major impact on the population structure of the durum wheat landraces, with three distinct clusters that corresponded to subsp. durum, turgidum and dicoccon being identified. The population structure of bread wheat landraces was mainly biased by geographic origin.

Conclusions
The results showed broader genetic diversity in the landraces compared to a reference set that included commercial varieties, and higher divergence between the landraces and the reference set in durum wheat than in bread wheat. The analyses revealed genomic regions whose patterns of variation were markedly different in the landraces and reference varieties, indicating loci that have been under selection during crop improvement, which could help to target breeding efforts. The results obtained from this work will provide a basis for future genome-wide association studies.
Drought tolerance of the grapevine, Vitis champinii cv. Ramsey, is associated with higher photosynthesis and greater transcriptomic responsiveness of abscisic acid biosynthesis and signaling
Authors: Cochetel Noé , Ghan Ryan , Toups Haley S. , Degu Asfaw , Tillett Richard L. , Schlauch Karen A. , Cramer Grant R. 
Published: February 2020

AbstractBackgroundGrapevine is an economically important crop for which yield and berry quality is strongly affected by climate change. Large variations in drought tolerance exist acrossVitisspecies. Some of these species are used as rootstock to enhance abiotic and biotic stress tolerance. In this study, we investigated the physiological and transcriptomic responses to water deficit of four different genotypes that differ in drought tolerance: Ramsey (Vitis champinii), Riparia Gloire (Vitis riparia), Cabernet Sauvignon (Vitis vinifera), and SC2 (Vitis vinifera x Vitis girdiana).ResultsRamsey was particularly more drought tolerant than the other three genotypes. Ramsey maintained a higher stomatal conductance and photosynthesis at equivalent levels of moderate water deficit. We identified specific and common transcriptomic responses shared among the four differentVitisspecies using RNA sequencing analysis. A weighted gene co-expression analysis identified a water deficit core gene set with the ABA biosynthesis and signaling genes,NCED3,RD29BandABI1as potential hub genes. The transcript abundance of many abscisic acid metabolism and signaling genes was strongly increased by water deficit along with genes associated with lipid metabolism, galactinol synthases and MIP family proteins. This response occurred at smaller water deficits in Ramsey and with higher transcript abundance than the other genotypes. A number of aquaporin genes displayed differential and unique responses to water deficit in Ramsey leaves. Genes involved in cysteine biosynthesis and metabolism were constitutively higher in the roots of Ramsey; thus, linking the gene expression of a known factor that influences ABA biosynthesis to this genotype’s increasedNCED3transcript abundance.ConclusionThe drought tolerant Ramsey maintained higher photosynthesis at equivalent water deficit than the three other grapevine genotypes. Ramsey was more responsive to water deficit; its transcriptome responded at smaller water deficits, whereas the other genotypes did not respond until more severe water deficits were reached. There was a common core gene network responding to water deficit for all genotypes that included ABA metabolism and signaling. The gene clusters and sub-networks identified in this work represent interesting gene lists to explore and to better understand drought tolerance molecular mechanisms.
Up-regulating autophagy by targeting the mTOR-4EBP1 pathway: a possible mechanism for improving cardiac function in mice with experimental dilated cardiomyopathy
Authors: Jin Bo , Shi Haiming , Zhu Jun , Wu Bangwei , Geshang Quzhen 
Published: February 2020

Abstract
Background
Autophagy plays a crucial role in the pathological process of cardiovascular diseases. However, little is known about the pathological mechanism underlying autophagy regulation in dilated cardiomyopathy (DCM).

Methods
We explored whether up-regulating autophagy could improve cardiac function in mice with experimental DCM through the mTOR-4EBP1 pathway. Animal model of DCM was established in BALB/c mice by immunization with porcine cardiac myosin. Both up- or down-regulation of autophagy were studied by administration of rapamycin or 3-MA in parallel. Morphology, Western blotting, and echocardiography were applied to confirm the pathological mechanisms.

Results
Autophagy was activated and autophagosomes were significantly increased in the rapamycin group. The collagen volume fraction (CVF) was decreased in the rapamycin group compared with the DCM group (9.21 ± 0.82% vs 14.38 ± 1.24%, P < 0.01). The expression of p-mTOR and p-4EBP1 were significantly decreased in rapamycin-induced autophagy activation, while the levels were increased by down-regulating autophagy with 3-MA. In the rapamycin group, the LVEF and FS were significantly increased compared with the DCM group (54.12 ± 6.48% vs 45.29 ± 6.68%, P < 0.01; 26.89 ± 4.04% vs 22.17 ± 2.82%, P < 0.05). As the inhibitor of autophagy, 3-MA aggravated the progress of maladaptive cardiac remodeling and declined cardiac function in DCM mice.

Conclusions
The study indicated a possible mechanism for improving cardiac function in mice with experimental DCM by up-regulating autophagy via the mTOR-4EBP1 pathway, which could be a promising therapeutic strategy for DCM.
How were situations of preventive and curative care expenditure for AIDS and medical burden of patients? Research based on "System of Health Accounts 2011"
Authors: Zhan Huan , Wu Qiong , Zang Shuang , Zhou Liangrong , Wang Xin 
Published: February 2020

Abstract
Background
The problem of AIDS response has not only involved public health, but also had a great impact on the family burden.The objective of this study was to estimate the preventive and curative care expenditure(PCE)for AIDS of Hunan Province in 2017 based on System of Health Accounts 2011(SHA2011)by quantity,financing scheme,health provider,health function,and to analyses the factors affecting patients’ medical burden.

Methods
Through stratified multi-stage sampling method, 1336 institutions were surveyed to obtain AIDS prevention and control data, and the official data collected from Health Statistical Yearbook, Health Financial Annual Reports and Government Input Monitoring System were used to estimate the AIDS PCE based on SHA2011. Univariate analyses and ordered logistic regression were used to evaluate the factors affecting the medical burden of AIDS patients.

Results
The AIDS PCE of Hunan Province in 2017 was 266.67 million, mainly flowed to hospitals and disease prevention and control institutions. The proportions of curative care expenditure(CCE) and prevention expenditure were 51.39 and 48.61% respectively. Prevention expenditure were mainly used for traditional prevention methods. All prevention expenditure and 88.52% of CCE were borne by public financing scheme. Family health expenditure accounted for 11.12% of CCE, but there were still some people with heavy burden of treatment. Non insurance, co-infection and length of stay are risk factors to the total hospitalization expenses(Totalexp)and the out-of-pocket payments(OOPs)(all p < 0.05,OR > 1). Taking the age group under 30 as the reference, the partial regression coefficient of the age group over 60 was statistically significant (OR(Totalexp) = 1.809, OR(OOPs) = 0.30).

Conclusion
The financing structure of the PCE for AIDS in Hunan Province was relatively stable and the flow of institutions was reasonable. The functional flow of expenditure embodied the principle of “prevention first”. China should incorporate oral PrEP into the national guidelines as soon as possible to improve the allocation efficiency of AIDS prevention resources. Meantime, several measures should be taken to reduce the medical burden of AIDS patients, including expanding the scope of government assistance, adjusting insurance compensation measures, increasing the rate of patients participating in insurance,encouraging commercial insurance to join the AIDS insurance system,and controlling length of stay in hospital.