bluuebunny/crossref_metadata_2025_split huggingface dataset:
LINC00174 is an oncogenic lncRNA of hepatocellular carcinoma and regulates miR‐320/S100A10 axis
Authors: Zhao Jin‐Tao , Chi Bao‐Jin , Sun Yao , Chi Nan‐nan , Zhang Xue‐mei , Sun Jia‐bin , Chen Ying , Xia Yong 
Published: March 2020

Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Multiple long non‐coding RNAs (lncRNAs) are recently identified as crucial oncogenic factors or tumour suppressors. In this study, we explored the effects of LINC00174 on the progression of HCC. Expression levels of LINC00174 and microRNA‐320 (miR‐320) in HCC tissue samples were measured using quantitative real‐time polymerase chain reaction (qRT‐PCR). The association between pathological indices and LINC00174 was also analysed. Human HCC cell lines Hep3B and Huh7 were used as cell models. CCK‐8 and bromodeoxyuridine (BrdU) assays were used to assess the effect of LINC00174 on HCC cell line proliferation. Flow cytometry was used to study the effect of LINC00174 on HCC apoptosis. Transwell assay was conducted to detect the effect of LINC00174 on migration and invasion. Furthermore, luciferase reporter assay and RNA immunoprecipitation (RIP) assay were used to confirm the binding relationship between miR‐320 and LINC00174. Additionally, western blot was used to detect the regulatory function of LINC00174 on oncogene S100 calcium binding protein A10 (S100A10). We demonstrated that LINC00174 expression in HCC clinical samples was significantly increased and this was correlated with higher T stage. Its overexpression remarkably accelerated proliferation and metastasis of HCC cells while reduced apoptosis. Accordingly, knockdown of it suppressed the malignant phenotypes of HCC cells. Overexpression of LINC00174 significantly reduced the expression of miR‐320 by sponging it, in turn enhanced the expression of S100A10. In conclusion, LINC00174 is a sponge of tumour suppressor miR‐320, enhances the expression of S100A10 indirectly and functions as an oncogenic lncRNA in HCC.Significance of the studyLINC00174 is a novel lncRNA, whose function is rarely investigated. It is reported that it is oncogenic in colorectal cancer, while its role in HCC remains unclear. Herein, we report that LINC00174 is significantly up‐regulated in HCC tissues and promotes the malignant phenotypes. We demonstrate that LINC00174 functions as a sponge for miR‐320, increases the expression level of oncogene S100A10 in HCC. This study helps clarify the mechanism of HCC tumorigenesis and progression, and uncover the role of LINC00174 in human disease.
Percutaneous Impella RP use for refractory right heart failure in adolescents and young adults—A multicenter U.S. experience
Authors: Qureshi Athar M. , Turner Mariel E. , O'Neill William , Denfield Susan W. , Aghili Nima , Badiye Amit , Gandhi Radhakrishan , Tehrani Behnam , Chang George , Oyama Jared K. , Sinha Shashank , Brozzi Nicolas , Morray Brian 
Published: March 2020

AbstractObjectiveTo assess the outcomes of the use of the percutaneous Impella RP device (Abiomed, Danvers, MA) in adolescents and young adults.BackgroundResults of the Impella RP device have been reported in adults, but a multicenter experience in adolescents and young adults has yet to be reported.MethodsPatients ≤21 years of age who underwent implantation of an Impella RP device for refractory right heart failure from June, 2016 to April, 2018 at nine U.S. Centers were included.ResultsA total of 12 adolescents, median age of 18 (14–21) years and median weight 74.4 (49–112.4) kg underwent Impella RP implantation (INTERMACS Profile 1 in nine and Profile 2 in three patients. The central venous pressure decreased from 20 (16–35) to 12 (7–17) mmHg, (p = .001). One patient was concomitantly supported with an intra‐aortic balloon pump (IABP) and the rest with a percutaneous/surgically placed left ventricular assist device. There was one adverse event related to the Impella RP device (thrombosis requiring explant). The support duration was 6.5 days (4.8 hr–18.4 days) and survival to hospital discharge was 83%. At a median follow‐up of 11 months (5 days–2.5 years), 8 of 12 (67%) patients are alive.ConclusionsIn this multicenter experience, the Impella RP device was found to be efficacious and safe when used in adolescents and young adults. Further studies are warranted to identify suitable young/pediatric candidates for Impella RP therapy for right heart failure.
Scalable Synthesis of a MoS2/Black Phosphorus Heterostructure for pH‐Universal Hydrogen Evolution Catalysis
Authors: Liang Tingting , Liu Yaoda , Cheng Yize , Ma Fei , Dai Zhengfei 
Published: March 2020

AbstractThe exploration and scalable synthesis of the earth‐abundant and excellent electrocatalysts without noble metal are crucial to the future hydrogen production and application. Herein, an affordable electrocatalyst is built through an in‐situ growth of MoS2 nanosheets vertically on the electro‐exfoliated black phosphorus (EEBP) for hydrogen evolution reaction (HER). The electro‐exfoliation achieves the high‐yield production of few‐layer BP lamellae from its bulk crystal, hosting the scalable synthesis of uniform MoS2/EEBP heterostructure. Moreover, the vertical growth manner can effectively aggrandize the exposed MoS2 edge sites and probably advance the catalytic activity to a certain extent. As for HER, such a MoS2/EEBP heterostructure exhibits promising catalytic performance with low overpotentials of 126 mV, 237 mV and 258 mV at 10 mA cm−2 (η10) as well as low Tafel slopes in both acid, alkaline and neutral media, respectively. The rationales behind the satisfactory catalytic properties are explained by density functional theory (DFT) calculations. Theoretically, it is revealed that the MoS2/EEBP heterostructure with a more neutral hydrogen adsorption energy can benefit the electrons migration and boost the water dissociation kinetics. This study presents an effective method to design and fabricate highly efficient heterostructure electrocatalysts through interface engineering towards hydrogen production.
Measurement of Residence Time Distributions in a Continuously Operated Spouted Bed
Authors: Pietsch Swantje , Schönherr Michael , Kleine Jäger Frank , Heinrich Stefan 
Published: March 2020

AbstractContinuous gas‐solid processes are applied in many industries with particulate products, e.g. for granulation or coating. In this contribution, the residence time behavior in a continuously operated prismatic spouted bed was determined by applying an impulse of magnetizable tracer particles. Experiments were performed with the original configuration and with separation plates including mouse holes of varying size between the different chambers of the ProCell 25 apparatus. It is shown that the shape of the residence time distribution is influenced by the separation plates. In order to quantify the backmixing between the chambers, discontinuous experiments were performed, and the bed mass distribution and the distribution of the tracer were measured and compared to the initial conditions.
Application of Nanoscale Zero‐Valent Iron‐Loaded Natural Zeolite for Tetracycline Removal Process
Authors: Lye Jimmy Wei Ping , Saman Norasikin , Noor Ahmad Mujahid Md , Mohtar Safia Syazana , Othman Nurul Sakinah , Sharuddin Siti Shilatul Najwa , Kong Helen , Mat Hanapi 
Published: March 2020

AbstractImmobilized nanoscale zero‐valent iron on natural zeolite (NI‐NZ) was synthesized for remediation of antibiotics‐contaminated wastewater. A series of characterization methods confirmed the success of preventing the agglomeration of nanoscale zero‐valent iron particles, using natural zeolite as supporting media. The equilibrium data fitted well with the Langmuir and Temkin models, whereas the pseudo‐second‐order and Elovich kinetic models were suitable to describe the kinetic data. The versatility of NI‐NZ was also tested in a coagulation‐flocculation process which increased the removal of tetracycline from 10 to 75 %.
Influence of the Temperature on Coccolith‐Containing Systems fromEmiliania huxleyiCultivations
Authors: Chairopoulou Makrina A. , Kratzer Fabian , Gross Roland , Herrmann Michael , Teipel Ulrich 
Published: March 2020

AbstractThermogravimetric analysis of a coccolith‐containing biogenic broth showed a three‐step degradation process. According to this system behavior, the biogenic broth was heated to specific temperatures and characterized in terms of its morphology, surface chemistry, and crystallinity. The elemental and organic composition of the treated samples was also evaluated and compared to the reference material. The presented results were acquired in an effort to exploit pretreatment scenarios for such a biogenic system that would improve and support a separation process.
Multiscale Modeling of Superheated Steam Drying of Particulate Materials
Authors: Le Kieu Hiep , Tran Thi Thu Hang , Nguyen Nguyen An , Kharaghani Abdolreza 
Published: March 2020

AbstractA multiscale model for predicting the superheated steam drying behavior of a packed bed filled with particulate porous material is presented. By using a reaction engineering approach (REA) a semi‐empirical model is developed that can describe the heat and mass transfer between a single particle and the surrounding drying agent. By analogy between superheated steam drying and hot air drying, the relative activation energy of the REA model is formulated. Next, the single‐particle drying model is fed into a continuum‐scale model of a packed bed. The temperature and moisture content of the solid and the vapor temperature are successfully predicted by the bed‐scale model. To endow the bed‐scale model with predictive capabilities, simulation results are compared with experimental literature data.
Gas‐Liquid Mixing in a Grid‐Disc Impeller Stirred Tank
Authors: Yang Fengling , Sun Haiyao , Zhang Cuixun 
Published: March 2020

AbstractTo enhance the gas‐liquid mixing performance in stirred tanks, the grid‐disc impeller was designed by replacing the solid disc of the standard Rushton impeller with a grid disc. Gas‐liquid hydrodynamics of the new impeller was studied by employing the Eulerian‐Eulerian two‐phase model coupled with the dispersed k‐ε turbulence model. Rotation of the impeller was simulated with the multiple reference frame method. Flow field, gas holdup, and power consumption were investigated and compared with the standard Rushton impeller. The numerical method was validated by comparing the gas holdup with literature. The grid‐disc impeller performed better than the Rushton impeller in terms of gas dispersion performance, axial pumping capacity, and energy requirement, indicating its potential for gas‐liquid mixing applications.
Colour metrics for image edge detection
Authors: Abasi Saeedeh , A. Tehran Mohammad , Fairchild Mark D. 
Published: March 2020

AbstractImage edge detection based on low‐level feature is usually performed on gray‐scale images. Some methods have been developed for edge detection on colour images based on low‐level feature, but they are not consistent with human colour perception. This research provides a new algorithm for edge detection based on the “HyAB” large‐colour‐difference formula. This algorithm uses Sobel operators for gradient‐magnitude calculations and Canny methods for localizing edge points. The performance of the new algorithm is qualitatively compared with Sobal and Canny methods using some challenging colour images. The results indicate that gradient magnitudes are best calculated using the HyAB colour‐difference formula, and that CIELAB and CIEDE2000 differences are not suitable for this purpose. Definition of gradient magnitudes according human perception is essential in applications such as quality control of fabric printing, calculation of disruptive colouration, and so on. The new algorithm is successful in accuracy and fine edge detection in comparison with the Sobel and Canny methods. The new method is quantitatively compared with state‐of‐the‐art methods using three datasets including BSDS500, MBDD, and BIPED. The correctness and accuracy of annotations of images in datasets have an important effect on results. The new method does not reach scores better than deep‐learning‐based methods, but it is simple and does not need training. It could probably have better results with improving noise‐suppression.
Revisiting van der Waals Radii: From Comprehensive Structural Analysis to Knowledge‐Based Classification of Interatomic Contacts
Authors: Chernyshov Ivan Yu. , Ananyev Ivan V. , Pidko Evgeny A. 
Published: March 2020

AbstractThe front cover artwork is provided by the TheoMAT group of ITMO University (Russia) and the Inorganic Systems Engineering Group of Delft University of Technology (The Netherlands). The image illustrates how one can find the most probable interatomic distance and determine the van der Waals parameters for interatomic interaction from extended and diverse structural datasets. The new approach for background elimination and analysis of extended bulk structural datasets is reported in our paper. Read the full text of the Article at 10.1002/cphc.201901083.
Sustainable human resource management and employee engagement: A holistic assessment instrument
Authors: Diaz‐Carrion Rosalia , López‐Fernández Macarena , Romero‐Fernandez Pedro M. 
Published: March 2020

AbstractFaced with the need to develop more responsible models of human resource management (HRM), the aim of this research is to develop a measurement instrument that allows the systematic assessment of sustainable HRM systems. The research provides a comprehensive framework of analysis for evaluating HRM sustainability by relying on the sustainability approach. The article proposes an evaluation of sustainable HRM systems per their balanced application of corporate social responsibility (CSR) principles. The research identifies the different CSR dimensions that characterize sustainable HRM systems, creates the measurement instrument, and theoretically—through a Delphi study—and empirically validates this measure on a sample of European firms.
Curtailing the Overpotential of Li–CO2 Batteries with Shape‐Controlled Cu2O as Cathode: Effect of Illuminating the Cathode
Authors: Jena Anirudha , Hsieh He Chin , Thoka Subashchandrabose , Hu Shu Fen , Chang Ho , Liu Ru Shi 
Published: March 2020

AbstractLi–air batteries are limited to lab‐scale research owing to the uninterrupted formation of discharge products. In the case of Li–CO2 batteries, the increase in overpotential caused by Li2CO3 formation results in cell death. In this study, Cu2O crystals having three different types of shapes (i.e., cubic, octahedral, and rhombic) were synthesized to compare their catalytic activity toward CO2 reactions. The full‐cycle and long‐term stability test revealed that rhombohedral Cu2O facilitates Li2CO3 decomposition more efficiently than that of cubic and octahedral Cu2O. The cycle was extended to investigate the photocatalytic activity of the rhombic Cu2O by illuminating the cell. The repeated cycles to 1 h showed a maximum overpotential of 1.5 V, which is 0.5 V lower than that of the cell without illumination. A postmortem analysis of the cell after dividing the cycles into segments demonstrated interesting results concerning the role of light and Cu2O during the cell cycle.
Central pattern generating networks in insect locomotion
Authors: Mantziaris Charalampos , Bockemühl Till , Büschges Ansgar 
Published: March 2020

AbstractCentral pattern generators (CPGs) are neural circuits that based on their connectivity can generate rhythmic and patterned output in the absence of rhythmic external inputs. This property makes CPGs crucial elements in the generation of many kinds of rhythmic motor behaviors in insects, such as flying, walking, swimming, or crawling. Arguably representing the most diverse group of animals, insects utilize at least one of these types of locomotion during one stage of their ontogenesis. Insects have been extensively used to study the neural basis of rhythmic motor behaviors, and particularly the structure and operation of CPGs involved in locomotion. Here, we review insect locomotion with regard to flying, walking, and crawling, and we discuss the contribution of central pattern generation to these three forms of locomotion. In each case, we compare and contrast the topology and structure of the CPGs, and we point out how these factors are involved in the generation of the respective motor pattern. We focus on the importance of sensory information for establishing a functional motor output and we indicate behavior‐specific adaptations. Furthermore, we report on the mechanisms underlying coordination between different body parts. Last but not least, by reviewing the state‐of‐the‐art knowledge concerning the role of CPGs in insect locomotion, we endeavor to create a common ground, upon which future research in the field of motor control in insects can build.
Validating environmental DNA metabarcoding for marine fishes in diverse ecosystems using a public aquarium
Authors: Morey Kevin C. , Bartley Timothy J. , Hanner Robert H. 
Published: March 2020

AbstractEnvironmental DNA metabarcoding has been widely touted as a powerful tool for monitoring biodiversity in marine ecosystems. However, this method still requires thorough validation and standardization before it can be widely applied for ecological monitoring. The potential utility of environmental DNA metabarcoding is greatest in systems with high levels of diversity, yet environmental DNA metabarcoding has typically been validated in closed systems with relatively low levels of diversity. Additionally, the use of a multiple marker approach has been minimally explored under controlled, closed systems in the literature. Using a pilot study, we assess the ability of eDNA metabarcoding to capture biodiversity in a highly diverse closed system at the Ripley's Aquarium of Canada in Toronto, Ontario. Our pilot study highlights several key knowledge gaps that must be addressed before metabarcoding can be employed for widespread use in ecological monitoring. We found that environmental DNA metabarcoding recovered just over 50% of target species and 80% of target genera within a closed marine system containing 107 species and 44 genera using previously published markers for COI, 12S, and 16S. Additionally, COI and 12S were found to identify fewer target species than 16S, with COI generating the most off‐target identifications, but maximum detection success was achievable by combining all three markers. We discuss numerous key limitations which currently present barriers to the application of eDNA metabarcoding for studying highly diverse marine systems. These include marker selection, data validation and confidence, and the complexity of abundant and diverse novel systems. This study highlights important, yet incompletely resolved, challenges of environmental DNA metabarcoding for the detection of marine fishes in a diverse closed system environment using a multiple marker approach.
Back to the future: Can Chinese doubling down and American muddling through fulfill 21st century needs for environmental governance?
Authors: Zhao Xiaofan , Young Oran R. , Qi Ye , Guttman Dan 
Published: March 2020

AbstractAt the close of the last millennium, prominent thinkers projected that the political systems of leading economies would converge during the coming years. Yet, research has shown that China and the United States have developed distinctive institutionalized governance processes (IGPs) to address environmental issues. Can these distinctive processes persist in turbulent times? In reality, the two countries seem to be decoupling in their economic ties and diverging in political pursuit. Under the current circumstances, what can we say about the ability of the two systems to meet emerging environmental challenges of the 21st century? We argue that neither system is likely to experience fundamental change during the foreseeable future. Current developments are highlighting differences between goal‐based governance strategies prominent in China and the rule‐based strategies of the United States. As the urgency of solving transcendent problems like climate change rises and political tensions grow, it is essential to work with divergent systems to address common problems.
Comfort and clinical events at the end of life of nursing home residents with and without dementia: The six‐country epidemiological PACE study
Authors: Miranda Rose , van der Steen Jenny T. , Smets Tinne , Van den Noortgate Nele , Deliens Luc , Payne Sheila , Kylänen Marika , Szczerbińska Katarzyna , Gambassi Giovanni , Van den Block Lieve ,   PACE
Published: March 2020

AbstractObjectivesWe aimed to investigate the occurrence rates of clinical events and their associations with comfort in dying nursing home residents with and without dementia.MethodsEpidemiological after‐death survey was performed in nationwide representative samples of 322 nursing homes in Belgium, Finland, Italy, the Netherlands, Poland, and England. Nursing staff reported clinical events and assessed comfort. The nursing staff or physician assessed the presence of dementia; severity was determined using two highly discriminatory staff‐reported instruments.ResultsThe sample comprised 401 residents with advanced dementia, 377 with other stages of dementia, and 419 without dementia (N = 1197). Across the three groups, pneumonia occurred in 24 to 27% of residents. Febrile episodes (unrelated to pneumonia) occurred in 39% of residents with advanced dementia, 34% in residents with other stages of dementia and 28% in residents without dementia (P = .03). Intake problems occurred in 74% of residents with advanced dementia, 55% in residents with other stages of dementia, and 48% in residents without dementia (P < .001). Overall, these three clinical events were inversely associated with comfort. Less comfort was observed in all resident groups who had pneumonia (advanced dementia, P = .04; other stages of dementia, P = .04; without dementia, P < .001). Among residents with intake problems, less comfort was observed only in those with other stages of dementia (P < .001) and without dementia (P = .003), while the presence and severity of dementia moderated this association (P = .03). Developing “other clinical events” was not associated with comfort.ConclusionsDiscomfort was observed in dying residents who developed major clinical events, especially pneumonia, which was not specific to advanced dementia. It is crucial to identify and address the clinical events potentially associated with discomfort in dying residents with and without dementia.