bluuebunny/crossref_metadata_2025_split huggingface dataset:
Warming winters threaten peripheral Arctic charr populations of Europe
Authors: Kelly Seán , Moore Tadhg N. , de Eyto Elvira , Dillane Mary , Goulon Chloé , Guillard Jean , Lasne Emilien , McGinnity Phil , Poole Russell , Winfield Ian J. , Woolway R. Iestyn , Jennings Eleanor 
Published: October 2020

AbstractAs the global climate warms, the fate of lacustrine fish is of huge concern, especially given their sensitivity as ectotherms to changes in water temperature. The Arctic charr (Salvelinus alpinusL.) is a salmonid with a Holarctic distribution, with peripheral populations persisting at temperate latitudes, where it is found only in sufficiently cold, deep lakes. Thus, warmer temperatures in these habitats particularly during early life stages could have catastrophic consequences on population dynamics. Here, we combined lake temperature observations, a 1-D hydrodynamic model, and a multi-decadal climate reanalysis to show coherence in warming winter water temperatures in four European charr lakes near the southernmost limit of the species’ distribution. Current maximum and mean winter temperatures are on average ~ 1 °C warmer compared to early the 1980s, and temperatures of 8.5 °C, adverse for high charr egg survival, have frequently been exceeded in recent winters. Simulations of winter lake temperatures toward century-end showed that these warming trends will continue, with further increases of 3–4 °C projected. An additional 324 total accumulated degree-days during winter is projected on average across lakes, which could impair egg quality and viability. We suggest that the perpetuating winter warming trends shown here will imperil the future status of these lakes as charr refugia and generally do not augur well for the fate of coldwater-adapted lake fish in a warming climate.
Emotion-Regulation in Psychosis: Patients with Psychotic Disorders Apply Reappraisal Successfully
Authors: Opoka Sandra M. , Sundag Johanna , Riehle Marcel , Lincoln Tania M. 
Published: October 2020

Abstract
Background
Emotion-regulation is assumed to be impaired in psychosis: patients with psychotic disorders (PD) self-report to use reappraisal less frequently than healthy controls (HC), but it is uncertain whether they are also less successful in applying reappraisal. Moreover, it has not been investigated whether the habitual use of reappraisal is associated with the ability to use reappraisal successfully.

Methods
To address these questions, PD (n = 60), a clinical control group of patients with anxiety disorders (AD; n = 40) and HC (n = 40) completed questionnaires on habitual emotion-regulation and alexithymia, performed tests on neurocognitive functioning and jumping-to-conclusion bias, and were subjected to an emotion-regulation paradigm, in which they were asked to down-regulate induced anxiety and sadness.

Results
No differences were found between PD and HC regarding the habitual use of reappraisal, but PD reported to use reappraisal more frequently than AD. All groups were able to down-regulate anxiety and sadness via reappraisal following instructions. The habitual use of reappraisal and the reduction of anxiety and sadness after instruction were uncorrelated.

Conclusion
These findings question the common assumption that PD use reappraisal less often or less successfully. At least under laboratory condition, PD do not appear to be impaired in reducing negative affect via reappraisal successfully.
Correction to: On the feasibility of automated prediction of bug and non-bug issues
Authors: Herbold Steffen , Trautsch Alexander , Trautsch Fabian 
Published: October 2020

The original version of this article unfortunately contained mistakes. Figures 8, 9 and 10 were incorrectly captured. Somehow, the plots in Fig. 8 were replaced with those from Fig. 9 and the original Fig. 8 was lost.
Stability of lipids during wet storage of the marine diatom Porosira glacialis under semi-preserved conditions at 4 and 20 °C
Authors: Dalheim Lars , Svenning Jon B. , Eilertsen Hans C. , Vasskog Terje , Olsen Ragnar L. 
Published: October 2020

AbstractCultivation of diatoms may help alleviate the pressure on wild fish stocks for marine nutrient availability in aquaculture feed and for human consumption. However, the lipids in microalgae biomass are easily deteriorated, both trough lipolysis and degradation of polyunsaturated fatty acids (PUFA). Proper storage conditions are therefore necessary to maintain the lipid quality. Additionally, the storage conditions must have a low cost and facilitate further processing of the biomass. In this study, we investigated the formation of free fatty acids, changes in lipid classes, and fatty acid composition of the psychrophilic marine diatom Porosira glacialis under storage. The wet biomass was stored for 14 days at 4 and 20 °C with either heat treatment, formic acid, or benzoic acid addition, and a control sample. Heat-treated and formic acid samples had the lowest rate of free fatty acid formation during storage. Mainly, polar lipids were hydrolyzed to free fatty acids and this occurred fastest at 20 °C. The fatty acid composition remained stable in heat-treated samples during storage, whereas a loss of PUFA was observed in the other treatments. The lack of effect from benzoic acid indicates that the loss of lipid quality stems from endogenous enzymes rather than exogenous organisms. Heat treatment and formic acid appeared to effectively reduce lipase activity, and potentially lipoxygenase and similar enzymes that affect the fatty acids. The low pH of the formic acid samples seems to have a negative effect on the PUFA content, in particular at 20 °C.
Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study
Authors: Rombach Ines , Iftikhar Marvi , Jhuti Gurleen S. , Gustavsson Anders , Lecomte Pascal , Belger Mark , Handels Ron , Castro Sanchez Amparo Y. , Kors Jan , Hopper Louise , Olde Rikkert Marcel , Selbæk Geir , Stephan Astrid , Sikkes Sietske A. M. , Woods Bob , Gonçalves-Pereira Manuel , Zanetti Orazio , Ramakers Inez H. G. B. , Verhey Frans R. J. , Gallacher John , Actifcare Consortium  , LeARN Consortium  , Landeiro Filipa , Gray Alastair M. ,   ROADMAP Consortium
Published: October 2020

Abstract
Purpose
The Quality of Life Alzheimer’s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available.

Methods
Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error.

Results
The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset.

Conclusions
The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.
Growth hormone deficiency and replacement therapy in adults: Impact on survival
Authors: van Bunderen Christa C. , Olsson Daniel S. 
Published: October 2020

AbstractIn a seminal paper from 1990, Rosen and Bengtsson suggested that hypopituitary patients with a presumed growth hormone (GH) deficiency (GHD) have an excess mortality. Later studies have confirmed this finding but have also shown that the cause of the increased risk of death in these patients is multifactorial, including unreplaced GHD as well as non-physiological replacement therapy of other deficiencies, the etiology of hypopituitarism, and the side effects of tumor treatment. Only a few studies have investigated mortality in hypopituitary patients with GHD receiving GH replacement therapy (GHRT): these studies are retrospective observational studies with a wide range of underlying diseases but most of them show a mortality that is not different from the general population. Even though the research field of survival in GHD patients with and without GHRT is lacking prospective randomized trials, the evidence suggests that GHD in hypopituitary patients contributes to an excess mortality and modern replacement therapy including GHRT will result in a mortality that is approaching normal. Herein, we review the literature in the field of survival in GHD patients with and without GHRT. In addition, we outline the most important issues when evaluating studies in this area.
Do open access journal articles experience a citation advantage? Results and methodological reflections of an application of multiple measures to an analysis by WoS subject areas
Authors: Basson Isabel , Blanckenberg Jaco P. , Prozesky Heidi 
Published: October 2020

AbstractThis study is one of the first that uses the recently introduced open access (OA) labels in the Web of Science (WoS) metadata to investigate whether OA articles published in Directory of Open Access Journals (DOAJ) listed journals experience a citation advantage in comparison to subscription journal articles, specifically those of which no self-archived versions are available. Bibliometric data on all articles and reviews indexed in WoS, and published from 2013 to 2015, were analysed. In addition to normalised citation score (NCS), we used two additional measures of citation advantage: whether an article was cited at all; and whether an article is among the most frequently cited percentile of articles within its respective subject area (pptopX %). For each WoS subject area, the strength of the relationship between access status (whether an article was published in an OA journal) and each of these three measures was calculated. We found that OA journal articles experience a citation advantage in very few subject areas and, in most of these subject areas, the citation advantage was found on only a single measure of citation advantage, namely whether the article was cited at all. Our results lead us to conclude that access status accounts for little of the variability in the number of citations an article accumulates. The methodology and the calculations that were used in this study are described in detail and we believe that the lessons we learnt, and the recommendations we make, will be of much use to future researchers interested in using the WoS OA labels, and to the field of citation advantage in general.
Rotational thromboelastometry results are associated with care level in COVID-19
Authors: Almskog Lou M. , Wikman Agneta , Svensson Jonas , Wanecek Michael , Bottai Matteo , van der Linden Jan , Ågren Anna 
Published: October 2020

AbstractHigh prevalence of thrombotic events in severely ill COVID-19 patients have been reported. Pulmonary embolism as well as microembolization of vital organs may in these individuals be direct causes of death. The identification of patients at high risk of developing thrombosis may lead to targeted, more effective prophylactic treatment. The primary aim of this study was to test whether rotational thromboelastometry (ROTEM) at admission indicates hypercoagulopathy and predicts the disease severity, assessed as care level, in COVID-19 patients. The study was designed as a prospective, observational study where COVID-19 patients over 18 years admitted to hospital were eligible for inclusion. Patients were divided into two groups depending on care level: (1) regular wards or (2) wards with specialized ventilation support. Conventional coagulation tests, blood type and ROTEM were taken at admission. 60 patients were included; age 61 (median), 67% men, many with comorbidities (e.g. hypertension, diabetes). The ROTEM variables Maximum Clot Firmness (EXTEM-/FIBTEM-MCF) were higher in COVID-19 patients compared with in healthy controls (p < 0.001) and higher in severely ill patients compared with in patients at regular wards (p < 0.05). Our results suggest that hypercoagulopathy is present early in patients with mild to moderate disease, and more pronounced in severe COVID-19 pneumonia. Non-O blood types were not overrepresented in COVID-19 positive patients. ROTEM variables showed hypercoagulopathy at admission and this pattern was more pronounced in patients with increased disease severity. If this feature is to be used to predict the risk of thromboembolic complications further studies are warranted.
The Memory-Modifying Potential of Optogenetics and the Need for Neuroethics
Authors: Adamczyk Agnieszka K. , Zawadzki Przemysław 
Published: October 2020

AbstractOptogenetics is an invasive neuromodulation technology involving the use of light to control the activity of individual neurons. Even though optogenetics is a relatively new neuromodulation tool whose various implications have not yet been scrutinized, it has already been approved for its first clinical trials in humans. As optogenetics is being intensively investigated in animal models with the aim of developing novel brain stimulation treatments for various neurological and psychiatric disorders, it appears crucial to consider both the opportunities and dangers such therapies may offer. In this review, we focus on the memory-modifying potential of optogenetics, investigating what it is capable of and how it differs from other memory modification technologies (MMTs). We then outline the safety challenges that need to be addressed before optogenetics can be used in humans. Finally, we re-examine crucial neuroethical concerns expressed in regard to other MMTs in the light of optogenetics and address those that appear to be unique to the memory-modifying potential of optogenetic technology.
The associations between different sleep patterns and osteoporosis based on the Osteoporosis Self-Assessment Tool for Asians
Authors: Wu Shaojun , Wang Pengbo , Guo Xiaofan , Sun Guozhe , Zhou Ying , Li Zhao , Yang Hongmei , Yu Shasha , Zheng Liqiang , Sun Yingxian 
Published: October 2020

Abstract

Summary

Based on the use of Osteoporosis Self-Assessment Tool for Asians (OSTA) to assess osteoporosis risk, we found that short sleep duration and taking a daytime nap had an increased risk of osteoporosis.

Purpose
To explore the associations between different sleep patterns with osteoporosis.

Methods
3659 postmenopausal women (average age of 60 years) were divided into low, middle, and high osteoporosis risk categories based on the Osteoporosis Self-Assessment Tool for Asians (OSTA). After having collected by a standard questionnaire, total and nocturnal sleep duration was collapsed to form categories of ≤ 6 h, > 6 h and ≤ 7 h, > 7 h and ≤ 8 h, > 8 h and ≤ 9 h, > 9 h, and daytime nap duration of 0 h and > 0 h.

Results
As a categorical variable, the total sleep duration of ≤ 6 h per day (OR = 1.34, 95% CI 1.04–1.72), nocturnal sleep duration of ≤ 6 h per night (OR = 1.65, 95% CI 1.24–2.18), and taking a daytime nap (OR = 1.33, 95% CI 1.09–1.64) had higher osteoporosis risk after adjustment for covariates. As a continuous variable, after the adjustment for covariates, both longer total (OR = 0.86, 95% CI 0.78–0.94) and nocturnal sleep duration (OR = 0.83, 95% CI 0.76–0.91) had lower risk of osteoporosis risk while taking longer daytime nap (OR = 1.10, 95% CI 1.02–1.19) had higher osteoporosis risk.

Conclusions
Postmenopausal women with both short total and nocturnal sleep duration (6 h or less) and taking a daytime nap had increased osteoporosis risk as assessed by OSTA.
Trends in tropospheric ozone concentrations and forest impact metrics in Europe over the time period 2000–2014
Authors: Proietti Chiara , Fornasier Maria Francesca , Sicard Pierre , Anav Alessandro , Paoletti Elena , De Marco Alessandra 
Published: October 2020

AbstractIn Europe, tropospheric ozone pollution appears as a major air quality issue, and ozone concentrations remain potentially harmful to vegetation. In this study we compared the trends of two ozone metrics widely used for forests protection in Europe, the AOT40 (Accumulated Ozone over Threshold of 40 ppb) which only depends on surface air ozone concentrations, and the Phytotoxic Ozone Dose which is the accumulated ozone uptake through stomata over the growing season, and above a threshold Y of uptake (PODY). By using a chemistry transport model, we found that European-averaged ground-level ozone concentrations (− 2%) and AOT40 metric (− 26.5%) significantly declined from 2000 to 2014, due to successful control strategies to reduce the emission of ozone precursors in Europe since the early 1990s. In contrast, the stomatal ozone uptake by forests increased from 17.5 to 26.6 mmol O3 m−2 despite the reduction in ozone concentrations, leading to an increase of potential ozone damage on plants in Europe. In a climate change context, a biologically-sound stomatal flux-based standard (PODY) as new European legislative standard is needed.
A Review on Recent Advances in the Constitutive Modeling of Bone Tissue
Authors: Pahr Dieter H. , Reisinger Andreas G. 
Published: October 2020

Abstract
Purpose of Review
Image-based finite element analysis (FEA) to predict and understand the biomechanical response has become an essential methodology in musculoskeletal research. An important part of such simulation models is the constitutive material model of which recent advances are summarized in this review.

Recent Findings
The review shows that existing models from other fields were introduced, such as cohesion zone (cortical bone) or phase-field models (trabecular bone). Some progress has been made in describing cortical bone involving physical mechanisms such as microcracks. Problems with validations at different length scales remain a problem.

Summary
The improvement of recent constitutive models is partially obscured by uncertainties that affect overall predictions, such as image quality and calibration or boundary conditions. Nevertheless, in vivo CT-based FEA simulations based on a sophisticated constitutive behavior are a very valuable tool for clinical-related osteoporosis research.
High velocity seawater air-conditioning with thermal energy storage and its operation with intermittent renewable energies
Authors: Hunt Julian David , Zakeri Behnam , Nascimento Andreas , Garnier Bruno , Pereira Márcio Giannini , Bellezoni Rodrigo Augusto , de Assis Brasil Weber Natália , Schneider Paulo Smith , Machado Pedro Paulo Bezerra , Ramos Dorel Soares 
Published: October 2020

AbstractThe rapid increase in cooling demand for air-conditioning worldwide brings the need for more efficient cooling solutions based on renewable energy. Seawater air-conditioning (SWAC) can provide base-load cooling services in coastal areas utilizing deep cold seawater. This technology is suggested for inter-tropical regions where demand for cooling is high throughout the year, and it has been implemented in islands with short distances from the coast and the deep sea. This paper proposes adjustments to the conventional design of SWAC plants to reduce implementation risks and costs. The approach is named high velocity SWAC and consists of increasing the excavation depth of the seawater pump station up to 20 m below the sea level, compared to 2 to 5 m in conventional SWAC projects. This allows a twofold increase in the speed of inlet pipeline seawater and cooling load of the plant. The cooling load can be expanded twofold with only 55% capital cost and 83% project costs, compared with the costs of a new system. In addition, this article shows that high velocity SWAC plants with thermal energy storage will have an important role supporting the dissemination of intermittent renewable sources of energy in regions where SWAC is a viable cooling alternative.
Conceptualizing Corporate Accountability in International Law: Models for a Business and Human Rights Treaty
Authors: Bernaz Nadia 
Published: October 2020

AbstractThis article conceptualizes corporate accountability under international law and introduces an analytical framework translating corporate accountability into seven core elements. Using this analytical framework, it then systematically assesses four models that could be used in a future business and human rights (BHR) treaty: the United Nations Guiding Principles on Business and Human Rights model, the Universal Declaration of Human Rights model, the progressive model, and the transformative model. It aims to contribute to the BHR treaty negotiation process by clarifying different options and possible trade-offs between them, while taking into account political realities. Ultimately, the article argues in favour of the BHR treaty embracing a progressive model of corporate accountability, which combines ambitious development of international law with realistic prospects of state support.
Impact of experimental thermal processing of artificially contaminated pea products on ochratoxin A and phomopsin A
Authors: Kunz Birgitta Maria , Voß Alexander , Dalichow Julia , Weigel Stefan , Rohn Sascha , Maul Ronald 
Published: October 2020

AbstractFungi of Aspergillus and Penicillium genus can infect peas (Pisum sativum), leading to a contamination with the nephrotoxic and carcinogenic ochratoxin A (OTA). Under unfavourable conditions, a fungus primarily found on lupines, Diapothe toxica, may also grow on peas and produce the hepatotoxic phomopsin A (PHOA). To study the effect of processing on OTA and PHOA content, two model products—wheat/rye-mixed bread with pea flour addition and pea pasta—were manufactured at small-business scale from artificially contaminated pea flour. The decrease of OTA and PHOA contents were monitored along the production process as indicators for toxin transformation. Pea bread dough was subjected to proofing for 30–40 min at 32 °C and baked at 250 °C to 230 °C for 40 min. OTA content (LODs < 0.1 μg/kg) showed a reduction in the bread crust (initially 17.0 μg/kg) to 88% and no reduction in the crumb (110%). For PHOA (LODs < 3.6 μg/kg), a decrease to approximately 21% occurred in the bread crust (initially 12.5 μg/kg), whilst for crumb, a less intense decrease to 91% was found. Pea pasta prepared with two toxin levels was extruded at room temperature, dried and cooked for 8 min in boiling water. In pea pasta, OTA was reduced from 29.8 to 13.9 μg/kg by 22% each after cooking, whilst 15% and 10% of the initial toxin amounts were found in the cooking water, respectively. For PHOA, 60% and 78% of initially 14.3 μg/kg and 7.21 μg/kg remained in the cooked pasta. As only the decrease of the initial content was measured and no specific degradation products could be detected, further research is needed to characterise potential transformation products. Heat treatment reduces the initial PHOA content stronger than the OTA content during pasta cooking and bread making. However, significant amounts of both toxins would remain in the final products.
A new series of axial algebras of Monster type $$(2\eta ,\eta )$$
Authors: Alsaeedi Mashaer 
Published: October 2020

AbstractWe construct a new series of $$n^2$$

n
2

-dimensional axial algebras of Monster type $$(2\eta ,\eta )$$

(
2
η
,
η
)

. They arise as subalgebras A of the Matsuo algebras $$M_\eta (^-O_{n+1}^+(3))$$

M
η

(
-

O

n
+
1

+

(
3
)

)

, generated by single and double axes. Also, we address the question of when these algebras are simple. While we do not solve this question, we formulate three concrete conjectures based on the calculation, using the computer algebra system GAP, of the roots of the determinant of the Gram matrix of the Frobenius form on A for several small values of n.