bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of ovarian transcriptomes reveals thousands of novel genes in the insect vectorRhodnius prolixus
Authors: Coelho Vitor Lima , Brito Tarcísio Fontenele de , Brito Ingrid Alexandre de Abreu , Cardoso Maira Arruda , Berni Mateus Antonio , Araujo Helena Maria Marcolla , Sammeth Michael , Pane Attilio 
Published: October 2020

AbstractRhodnius prolixusis a Triatominae insect species and a primary vector of Chagas disease. The genome ofR. prolixushas been recently sequenced and partially assembled, but few transcriptome analyses have been performed to date. In this study, we describe the stage-specific transcriptomes obtained from previtellogenic stages of oogenesis and from mature eggs. By analyzing ~228 million paired-end RNA-Seq reads, we significantly improved the current genome annotations for 9,206 genes. We provide extended 5’ and 3’ UTRs, complete Open Reading Frames, and alternative transcript variants. Strikingly, using a combination of genome-guided andde novotranscriptome assembly we found more than two thousand novel genes, thus increasing the number of genes inR. prolixusfrom 15,738 to 17,864. We used the improved transcriptome to investigate stage-specific gene expression profiles duringR. prolixusoogenesis. Our data reveal that 11,127 genes are expressed in the early previtellogenic stage of oogenesis and their transcripts are deposited in the developing egg including key factors regulating germline development, genome integrity, and the maternal-zygotic transition. In addition, GO term analyses show that transcripts encoding components of the steroid hormone receptor pathway, cytoskeleton, and intracellular signaling are abundant in the mature eggs, where they likely control early embryonic development upon fertilization. Our results significantly improve theR. prolixusgenome and transcriptome and provide novel insight into oogenesis and early embryogenesis in this medically relevant insect.
Cortical myosin minifilaments orchestrate the arrangement of microridge protrusions on epithelial cell surfaces
Authors: van Loon Aaron P. , Erofeev Ivan S. , Goryachev Andrew B. , Sagasti Alvaro 
Published: October 2020

ABSTRACTActin-based protrusions vary in morphology, stability, and arrangement on cell surfaces. Microridges are laterally-elongated protrusions arranged in maze-like patterns on mucosal epithelial cells that rearrange dynamically by fission and fusion. To characterize how microridges mature and investigate the mechanisms driving fission and fusion, we imaged microridges in the maturing skin of zebrafish larvae. After their initial development, microridges continued to lengthen and microridge alignment became increasingly well ordered. Imaging F-actin and Non-Muscle Myosin II (NMII) revealed that microridge fission and fusion were associated with local NMII activity in the apical cortex. Inhibiting NMII blocked rearrangements, reduced microridge density, and altered microridge spacing. High-resolution imaging revealed that individual cortical NMII minifilaments are tethered to protrusions, often connecting adjacent microridges. NMII minifilaments connecting the ends of microridges fused them together, whereas minifilaments oriented perpendicular to microridges severed them or pulled them closer together. Our findings demonstrate that as cells mature, microridges continue to remodel and form an increasingly orderly arrangement through a process orchestrated by cortical NMII contraction.
Managing moral reformation: the case of Queensland's reformatory for boys, 1871–1919
Authors: Clarissa Carden 
Published: October 2020

PurposeThis article explores the case of the Queensland's reformatory for boys through the years 1871–1919 to analyse how the institution negotiated the complex, and at times competing, goals of reforming, educating and punishing its inmate population.Design/methodology/approachThe article relies on documentary evidence, including archival material produced by the institution and newspaper records published between 1865, when the legislation allowing the institution to be created was passed, to 1919, when the institution ceased to be known as a “reformatory”.FindingsThis research demonstrates that, despite considerable changes during the studied period, the overarching goal of reforming criminal and potentially criminal young people continuously relied on achieving a balance between reformative techniques such as religious instruction and work placements, providing a useful education and punishing offenders. It also demonstrates that, despite efforts to achieve this balance, the institution was often described as unsuccessful.Originality/valueDue to the paucity of available archival evidence, there is still relatively little known about how the reformatories of late-19th- and early-20th-century Australia attempted to carry out programmes of moral reformation. This paper contributes to the field through an analysis of an institution which faced unusual challenges as a result of a complex inmate population.
Educational perspective on interreligious relations among Muslims, Christians and Kaharingan adherents in Central Kalimantan, Indonesia
Authors: Qodir Abdul 
Published: October 2020

Purpose
This paper aims to investigate how do Muslims, Christians and Kaharingan adherents conduct interreligious relations among them in their everyday lives in Central Kalimantan; why do these religious communities observe interreligious relations as such; and what makes this model of interreligious relations.

Design/methodology/approach
The corpus for analysis comes from in-depth interviews with 20 persons, which took place between August and October in 2016 in Palangka Raya city and Kotawaringin Timur Regency in Central Kalimantan Province, Indonesia. The informants were selected from groups believed to be lay members and elites of Muslim, Christian and Kaharingan communities using snowball sampling technique facilitated by local research assistants. These informants are mainly mainstream Muslims, Christians and Kaharingan adherents.

Findings
The way to peaceful and co-existence life lived by religious communities in Indonesia is closely related to its rich treasures and precious tradition of cultural heritage: Indonesian communalism, Indonesian community spirit as seen in terms such as “tradisi hidup bersama,” “semangat kebersamaan” and “satu keluarga.” Instead of emphasizing the divisive differences among communities with various religious backgrounds, Muslims, Christians and Kaharingan adherents in Central Kalimantan create “third spaces,” common grounds shared by these religious communities at individual, institutional and societal levels.

Originality/value
Based on empirical findings, this research argues that the practices of peaceful and co-existence life lived by diverse religious communities in Indonesia relate to their particular social-cultural contexts of rich treasures and precious tradition of cultural heritage in the forms of Indonesian communalism and community spirit. Instead of emphasizing the divisive differences among themselves, various religious communities in Central Kalimantan create third spaces, common grounds between them and are shared by them at individual, institutional and societal levels.
Muslim tourists’ intention to book on Airbnb: the moderating role of gender
Authors: Tiamiyu Tosin , Quoquab Farzana , Mohammad Jihad 
Published: October 2020

PurposeThe purpose of this study is to investigate the impact of reputation on perceived value towards Muslim tourists’ booking intention on Airbnb, particularly from the Malaysian perspective. Additionally, this study investigates the moderating role of gender on the relationship between perceived value and guest booking intention.Design/methodology/approachThis study considered the Stimulus–Organism–Response (S-O-R) theory to develop the research framework. Using a self-administered survey questionnaire, 156 completed and usable responses were obtained. The data were analysed by applying partial least squares–structural equation modelling technique, more specifically by using SmartPLS (version 3) software.FindingsThe study findings revealed that both reputation and perceived value positively affect Muslim tourists’ booking intention on Airbnb service. Moreover, it is also found that, gender plays a moderating role on guests’ intention to book accommodation on the Airbnb platform.Practical implicationsIt is expected that the findings of this study can help the practitioners in the hospitality industry, particularly in strategising their marketing efforts to attract more tourists to engage in a meaningful relationship with the Airbnb in Malaysia. It is suggested that, the Airbnb hosts need to consider the reputation (stimulus) and perceived value (organism) in their marketing strategy to foster Muslim guests’ booking intention.Originality/valueTo the best of the authors’ knowledge, this work is among the first to examine the predictors of Muslim tourists’ booking intention on Airbnb. Moreover, very little is known on the moderating role of gender on perceived value and its association with booking intention, which this research attempts to address.
A call to action for virtual team leaders: practitioner perspectives on trust, conflict and the need for organizational support
Authors: Turesky Elizabeth Fisher , Smith Coby D. , Turesky Ted K. 
Published: October 2020

Purpose
The purpose of this study is to investigate the leadership behaviors of managers of virtual teams (VTs), particularly in the areas of trust building and conflict management. This study aims to expand the research of VT performance by offering first-person accounts from VT leaders on the strategies implemented to drive VT performance.

Design/methodology/approach
This study used a grounded theory approach to examine the leadership behaviors through in-depth interviews with eight field managers of VTs employed by different technology companies. Interview questions focused on trust-building and conflict management techniques. This structured qualitative study incorporates elements of narrative inquiry interwoven in the findings.

Findings
Building a high-trust environment was found to be critical to VT performance. VT managers indicated that effective conflict resolution skills were also important.

Research limitations/implications
Although the sample size is within the suggested range for a valid phenomenological study, the results may lack generalizability. Participants were limited to the technology industry; leaders of high-performing VTs in other industries could offer differing results.

Practical implications
This study’s contribution is the exploration and identification of innovative techniques that VT managers implemented to build trust and resolve conflict. A lack of holistic training programs for the VT leader is also considered along with suggestions for future research and implications for the VT managers.

Originality/value
This study’s contribution is the exploration and identification of innovative techniques that VT managers implemented that drive VT performance, particularly related to building high levels of trust and managing conflict effectively. Practices are suggested whereby both the VT leader and the organization take an active role in ensuring that the VT has the opportunity to perform optimally.
Detection of a pederin‐like compound using a dilution‐to‐extinction‐based platform for the isolation of marine bacteria in drug discovery strategies
Authors: Benítez Xulio , Gonzalez Elena G. , García Jesus , Zúñiga Paz , de la Calle Fernando , Cuevas Carmen 
Published: October 2020

SummaryThe continued development of culturing technologies for the discovery of new molecules from marine microbes is of paramount importance for drug discovery. Coupled with this, the use of the high‐throughput approach shows promise for increasing the number of Gram‐negative and non‐filamentous bacteria cultures that can be surveyed, since they show a lower potential of bioactivity. In this work, we propose a new strategy of high‐throughput cultivation of bacteria inspired by a dilution‐to‐extinction (DTE) methodology for the isolation of, and screening for, new cytotoxic compound producing marine bacteria. A marine sponge tissue was directly used as inoculum and the results were compared with the data obtained through the direct plating isolation method. Enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC‐PCR) genomic fingerprinting indicated the isolation of four bioactive strains, three of them producers of a pederin‐like compound, and the fourth one able to synthesize a different compound, still unidentified, rendered by the DTE approach, in comparison with one bioactive strain identified through the plating method. Analyses based on the 16S rRNA gene data showed the existence of two different species belonging to the genus Labrenzia. The efficiency and diversity ratio in the number of isolates and compounds are discussed. In view of the results, the proposed DTE approach proved to be efficient for the isolation of new cytotoxic compounds of marine origin and pave the way for future potential applications.
Information linkages among National, NSW, VIC, and QLD real estate markets in Australia
Authors: Wang JingJing (Justine) , Croucher John S. 
Published: October 2020

AbstractWe examine information and volatility linkages among NATIONAL, NSW, VIC and QLD housing markets in Australia using the novel rational expectations framework of financial contagion and a combination of robust econometric methods including the Generalised Method of Moments (GMM), correlations and Generalised Impulse Response Method, etc. We find information linkages across markets are revealed in the correlations of their volatilities and correlations of the house price returns. Moreover, we find these volatilities reflect house price patterns of the most important four real estate economic cycles over the last two decades.
Financial Consumers’ Sense of Purpose and Consistent Financial Decisions: Experimental Evidence from South Korea*
Authors: Park Na Young 
Published: October 2020

AbstractThis paper examines the association between financial consumers’ sense of purpose and the consistency of their choices when they make investment decisions. The data are based on two controlled experiments conducted in South Korea. The first main result shows that financial consumers’ psychological well‐being has a positive association with choice consistency. The second result confirms the causal relationship between sense of purpose and choice consistency.
Co‐morbidities and mortality associated with transfusion‐dependent beta‐thalassaemia in patients in England: a 10‐year retrospective cohort analysis
Authors: Jobanputra Minesh , Paramore Clark , Laird Sandra G. , McGahan Michael , Telfer Paul 
Published: October 2020

SummaryA retrospective cohort analysis to explore 10‐year mortality and prevalence of transfusion‐dependent β‐thalassaemia (TDT)‐associated co‐morbidities in patients with TDT was undertaken using Hospital Episode Statistics (HES) data from the National Health Service (NHS) in England. A 10‐year forward‐looking cohort analysis for the period 2009–2018 was completed using HES admitted patient care (APC), outpatient data, and linked HES/Office of National Statistics mortality data for patients with β‐thalassaemia (ICD‐10 diagnosis code D56.1). TDT‐associated co‐morbidity rates were high in the 612 patients with TDT, with 76% having at least one co‐morbidity, 54% suffering from two of more, and 37% three or more. The three most common TDT‐associated co‐morbidities, occurring in more than one third of patients were: endocrine disorders (excluding diabetes) 40%, osteoporosis 40%, and diabetes 34%. Cardiac disease was observed in 18% of patients overall, with atrial fibrillation and heart failure being the most common with a prevalence of 11% and 9%, respectively. The crude 10‐year mortality rate in the TDT cohort was 6·2% (38/612), significantly greater than the 1·2% age/sex‐adjusted mortality rate of the general population (P < 0·001). These data support the notion that the unmet need in TDT remains significant, with high rates of co‐morbidity and mortality.
Sentiment analysis of tweets using a unified convolutional neural network‐long short‐term memory network model
Authors: Umer Muhammad , Ashraf Imran , Mehmood Arif , Kumari Saru , Ullah Saleem , Sang Choi Gyu 
Published: October 2020

AbstractSentiment analysis focuses on identifying and classifying the sentiments expressed in text messages and reviews. Social networks like Twitter, Facebook, and Instagram generate heaps of data filled with sentiments, and the analysis of such data is very fruitful when trying to improve the quality of both products and services alike. Classic machine learning techniques have a limited capability to efficiently analyze such large amounts of data and produce precise results; they are thus supported by deep learning models to achieve higher accuracy. This study proposes a combination of convolutional neural network and long short‐term memory (CNN‐LSTM) deep network for performing sentiment analysis on Twitter datasets. The performance of the proposed model is analyzed with machine learning classifiers, including the support vector classifier, random forest (RF), stochastic gradient descent (SGD), logistic regression, a voting classifier (VC) of RF and SGD, and state‐of‐the‐art classifier models. Furthermore, two feature extraction methods (term frequency‐inverse document frequency and word2vec) are also investigated to determine their impact on prediction accuracy. Three datasets (US airline sentiments, women's e‐commerce clothing reviews, and hate speech) are utilized to evaluate the performance of the proposed model. Experiment results demonstrate that the CNN‐LSTM achieves higher accuracy than those of other classifiers.
The relationship between resting heart rate and new‐onset microalbuminuria in people with type 2 diabetes: An 8‐year follow‐up study
Authors: Chang Y. K. , Fan H. C. , Lim P. S. , Chuang S. Y. , Hsu C. C. 
Published: October 2020

AbstractAimsMicroalbuminuria is an indicator of adverse cardiovascular events and chronic kidney disease. Studies have described an elevated resting heart rate as a risk factor for microalbuminuria in people with cardiovascular disease, but none have clarified its role in microalbuminuria development in people with type 2 diabetes. Therefore, this study investigated the relationship between resting heart rate and new‐onset microalbuminuria in type 2 diabetes.MethodsA total of 788 people from a glycaemic control trial in Taiwan were enrolled. Microalbuminuria was defined as a fasting urine albumin‐to‐creatinine ratio ≥30 mg/g in two consecutive urine tests. Resting heart rate and other covariates were measured at baseline. The quartile of resting heart rates, categorized as <70, 70–74, 75–80 and >80 beats/min, was used for analysis. Cox proportional hazard models were used to evaluate the association between resting heart rate and risk of microalbuminuria.ResultsDuring the follow‐up period, 244 people (31%) developed microalbuminuria. Those who developed microalbuminuria had a longer diabetes duration (median = 3.0 vs. 2.0 years, p < 0.001), higher rate of hypertension (77% vs. 66%, p = 0.003), higher rate of angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker treatment (50% vs. 38%, p = 0.001) and higher baseline HbA1c level (70 vs. 64 mmol/mol, 8.6 vs. 8.0%, p < 0.001). After adjusting for demographics, metabolic profiles and inflammatory markers, developing microalbuminuria was significantly associated with baseline resting heart rate of 70–74, 75–80 and >80 beats/min (with hazard ratios [95% CI] of 2.05 [1.32, 3.18], 2.10 [1.32, 3.32] and 1.62 [1.01, 2.59], respectively) compared to resting heart rates <70 beats/min. An average increased risk of microalbuminuria for increment of 10 beats/min was about 24% among those with hypertension (with hazard ratios of 1.24 [1.05, 1.47] in the multivariable Cox model).ConclusionsThis prospective cohort study showed that resting heart rate may be an associative risk factor for developing microalbuminuria in type 2 diabetes.
The impact of U.S. sanctions on Iran’s engagement and integration in the Belt and Road Initiative
Authors: Chaziza Mordechai 
Published: October 2020

AbstractThis study seeks to examine the new dynamic of the growing comprehensive strategic partnership between Iran and China in order to understand the impact and the extent of the reimposition of U.S. secondary sanctions on Iran’s engagement and integration in the implementation of the Belt and Road Initiative. Tehran has a special geographical and communication status in West Asia which makes it one of the important centerpieces of the new Silk Road trade route. However, Washington’s decision to withdraw from the Iran nuclear agreement and to reimpose sanctions has created barriers in the new dynamic in Sino‐Iranian trade and obstacles to integrating Iran into the realization of the Belt and Road Initiative.
Welfare and management of decreased visual capacities and pain in a pony suffering from equine recurrent uveitis: A clinical case
Authors: de Boyer des Roches A. , Peyrecave‐Capo X. , Rocafort‐Ferrer G. , Thomas A. , Roche H. , Desjardins I. , Mounier L. , Cadoré J.‐L. 
Published: October 2020

SummaryThis clinical case describes a 14‐year‐old Gypsy Cob gelding presented for suspected impaired vision. Given the apparently insidious presentation, bilateral equine recurrent uveitis (ERU) was strongly suspected. ERU management was addressed both clinically and from a welfare point of view. Treatment using ointment was preferred to eye drops to reduce the frequency of administration. Clicker training was used to facilitate treatment administration by eliciting positive emotions. In response to the progressive bilateral blindness, social and physical environments and new relational practices were adapted to reduce stress on the pony by increasing predictability and controllability of his situation. This case is to our knowledge the first to include detailed welfare management strategies as a part of a more comprehensive medical approach to ERU.
Methylprednisolone alleviates multiple sclerosis by expanding myeloid‐derived suppressor cells via glucocorticoid receptor β and S100A8/9 up‐regulation
Authors: Wang Zhongkun , Zheng Ge , Li Guangjian , Wang Mengkun , Ma Zhanchuan , Li Huimin , Wang Xiang‐Yang , Yi Huanfa 
Published: October 2020

AbstractMethylprednisolone is an effective drug in the treatment of autoimmune disease, such as multiple sclerosis (MS), due to long‐acting anti‐inflammatory, antiallergic and immunosuppressant. Previous studies have noted the importance of myeloid‐derived suppressor cells (MDSC) in MS progression. However, it is still not known whether methylprednisolone could influence the ratio and function of MDSC during MS treatment. In the current study, we found an increased ratio of MDSC at the onset of EAE in mice model; but methylprednisolone pulse therapy (MPPT) did not alter the percentage and suppressive function of MDSC during disease attenuation. However, the percentage of G‐MDSC in PBMC significantly increased in patients with MS. Surprisingly, relapsing MS patients showed a significant increase in both M‐MDSC and G‐MDSC after MPPT. The disease remission positively correlated expansion of MDSC and expression of arginase‐1. Additionally, MPPT reduced the expression of inhibitory glucocorticoid (GCs) receptor β subunit on MDSC while elevating serum levels of immune regulatory S100A8/A9 heterodimer. Thus, MDSC dynamics and function in mouse EAE differ from those in human MS during MPPT. Our study suggested that GCs treatment may help relieve the acute phase of MS by expanding MDSC through up‐regulating of GR signalling and S100A8/A9 heterodimers.