bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the experience of initiating community-based group physical activity by people with serious mental illness: A systematic review using a meta-ethnographic approach
Authors: Quirk Helen , Hock Emma , Harrop Deborah , Crank Helen , Peckham Emily , Traviss-Turner Gemma , Machaczek Katarzyna , Stubbs Brendon , Horspool Michelle , Weich Scott , Copeland Robert 
Published: October 2020

Abstract

Background
People living with serious mental illness (SMI) experience debilitating symptoms that worsen their physical health and quality of life. Regular physical activity (PA) may bring symptomatic improvements and enhance wellbeing. When undertaken in community-based group settings, PA may yield additional benefits such as reduced isolation. Initiating PA can be difficult for people with SMI, so PA engagement is commonly low. Designing acceptable and effective PA programs requires a better understanding of the lived experiences of PA initiation among people with SMI.

Methods
This systematic review of qualitative studies used the meta-ethnography approach by Noblit and Hare (1988). Electronic databases were searched from inception to November 2017. Eligible studies used qualitative methodology; involved adults (≥18 years) with schizophrenia, bipolar affective disorder, major depressive disorder, or psychosis; reported community-based group PA; and captured the experience of PA initiation, including key features of social support. Study selection and quality assessment were performed by four reviewers.

Results
Sixteen studies were included in the review. We identified a “journey” that depicted a long sequence of phases involved in initiating PA. The journey demonstrated the thought processes, expectations, barriers, and support needs of people with SMI. In particular, social support from a trusted source played an important role in getting people to the activity, both physically and emotionally.

Discussion
The journey illustrated that initiation of PA for people with SMI is a long complex transition. This complex process needs to be understood before ongoing participation in PA can be addressed. Registration—The review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) on 22/03/2017 (registration number CRD42017059948).
Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice
Authors: Bocco Barbara M L C , Fernandes Gustavo W , Fonseca Tatiana L , Bianco Antonio C 
Published: October 2020

Abstract
More than a billion people worldwide are at risk of iodine deficiency (ID), with well-known consequences for development of the central nervous system. Furthermore, ID has also been associated with dyslipidemia and obesity in humans. To further understand the metabolic consequences of ID, here we kept 8-week-old C57/Bl6 mice at thermoneutrality (~28°C) while feeding them on a low iodine diet (LID). When compared with mice kept on control diet (LID + 0.71 μg/g iodine), the LID mice exhibited marked reduction in T4 and elevated plasma TSH, without changes in plasma T3 levels. LID mice grew normally, and had normal oxygen consumption, ambulatory activity, and heart expression of T3-responsive gene, confirming systemic euthyroidism. However, LID mice exhibited ~5% lower respiratory quotient (RQ), which reflected a ~2.3-fold higher contribution of fat to energy expenditure. LID mice also presented increased circulating levels of nonesterified fatty acids, ~60% smaller fat depots, and increased hepatic glycogen content, all indicative of accelerated lipolysis. LID mice responded much less to forced mobilization of energy substrates (50% food restriction for 3 days or starvation during 36 hours) because of limited size of the adipose depots. A 4-day treatment with T4 restored plasma T4 and TSH levels in LID mice and normalized RQ. We conclude that ID accelerates lipolysis and fatty acid oxidation, without affecting systemic thyroid hormone signaling. It is conceivable that the elevated plasma TSH levels trigger these changes by directly activating lipolysis in the adipose tissues.
Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway
Authors: Hua Renwu , Zhang Xiuling , Li Wenchao , Lian Weisi , Liu Qiaorui , Gao Dengying , Wang Yueying , Lei Minggang 
Published: October 2020

ABSTRACT
Endometrial receptivity plays a vital role in successful embryo implantation in pigs. MicroRNAs (miRNAs), known as regulators of gene expression, have been implicated in the regulation of embryo implantation. However, the role of miRNAs in endometrial receptivity during the pre-implantation period remains elusive. In this study, we report that the expression level of Sus scrofa (ssc)-miR-21-5p in porcine endometrium tissues was significantly increased from day 9 to day 12 of pregnancy. Knockdown of ssc-miR-21-5p inhibited proliferation and migration of endometrial epithelial cells (EECs), and induced their apoptosis. We verified that programmed cell death 4 (PDCD4) was a target gene of ssc-miR-21-5p. Inhibition of PDCD4 rescued the effect of ssc-miR-21-5p repression on EECs. Our results also revealed that knockdown of ssc-miR-21-5p impeded the phosphorylation of AKT (herein referring to AKT1) by targeting PDCD4, which further upregulated the expression of Bax, and downregulated the levels of Bcl2 and Mmp9. Furthermore, loss of function of Mus musculus (mmu)-miR-21-5p in vivo resulted in a decreased number of implanted mouse embryos. Taken together, knockdown of ssc-miR-21-5p hampers endometrial receptivity by modulating the PDCD4/AKT pathway.
Can We Reliably Identify the Pathological Outcomes of Neoadjuvant Chemotherapy in Patients with Breast Cancer? Development and Validation of a Logistic Regression Nomogram Based on Preoperative Factors
Authors: Zhang Jian , Xiao Linhai , Pu Shengyu , Liu Yang , He Jianjun , Wang Ke 
Published: October 2020

Abstract
Background
Pathological responses of neoadjuvant chemotherapy (NCT) are associated with survival outcomes in patients with breast cancer. Previous studies constructed models using out-of-date variables to predict pathological outcomes, and lacked external validation, making them unsuitable to guide current clinical practice.

Objective
The aim of this study was to develop and validate a nomogram to predict the objective remission rate (ORR) of NCT based on pretreatment clinicopathological variables.

Methods
Data from 110 patients with breast cancer who received NCT were used to establish and calibrate a nomogram for pathological outcomes based on multivariate logistic regression. The predictive performance of this model was further validated using a second cohort of 55 patients with breast cancer. Discrimination of the prediction model was assessed using an area under the receiver operating characteristic curve (AUC), and calibration was assessed using calibration plots. The diagnostic odds ratio (DOR) was calculated to further evaluate the performance of the nomogram and determine the optimal cut-off value.

Results
The final multivariate regression model included age, NCT cycles, estrogen receptor, human epidermal growth factor receptor 2 (HER2), and lymphovascular invasion. A nomogram was developed as a graphical representation of the model and showed good calibration and discrimination in both sets (an AUC of 0.864 and 0.750 for the training and validation cohorts, respectively). Finally, according to the Youden index and DORs, we assigned an optimal ORR cut-off value of 0.646.

Conclusion
We developed a nomogram to predict the ORR of NCT in patients with breast cancer. Using the nomogram, for patients who are operable and whose ORR is < 0.646, we believe that the benefits of NCT are limited and these patients can be treated directly using surgery.
Establishing local diagnostic reference levels for common orthopaedic procedures using the mini C-arm fluoroscope
Authors: Kropelnicki Anna , Eaton Rosemary , Adamczyk Alexandra , Waterman Jacqueline , Mohaghegh Pegah 
Published: October 2020

Objective:
Mini C-arm fluoroscopes are widely used by orthopaedic surgeons for intraoperative image guidance without the need for radiographers. This puts the responsibility for radiation exposure firmly with the operating surgeon. In order to maintain safe and best practice under U.K. Ionising Radiation (Medical Exposure) Regulations, one must limit radiation exposure and audit performance using national diagnostic reference levels (DRLs). In the case of the mini C-arm, there are no national DRLs. IR(ME)R, therefore, require the establishment of local DRLs by each hospital to act as an alternative guideline for safe radiation use. The aim of our audit was to establish local DRLs based on our experience operating with the use of the mini C-arm over the last 7 years.

Methods:
This retrospective audit evaluates the end dose–area product (DAP) recorded for common trauma and orthopaedic procedures using the mini C-arm in a busy district general hospital.
We present the quartile data and have set the cut-off point as the third quartile for formulating the local DRLs, consistent with the methodology for the conventional fluoroscope.

Results:
For our data set (n = 1664), the third quartile DAP values were lowest for surgeries to the forearm (5.38 cGycm2), hand (7.62 cGycm2), and foot/ankle (8.56 cGycm2), and highest for wrist (10.64 cGycm2) and elbow (14.61 cGycm2) procedures.

Advances in knowledge:
To our knowledge, this is the largest data set used to establish local DRLs. Other centres may find our guidelines useful whilst they establish their own local DRLs.
Assessing the role of the universal addition of CT thorax to CT abdomen and pelvis in the COVID era. A retrospective multicentre cohort study
Authors: Brennan Christopher Anthony , Morrissey Brian , Dubois-Marshall Sylvie , McAteer Dympna , Qadir Abdul , Ramsay George 
Published: October 2020

Objective: The SARS-CoV2 infection is associated with high mortality for individuals who undergo emergency surgery. The United Kingdom surgical associations and Colleges of Surgeons collectively recommended the addition of CT Thorax to all emergency CT abdomen/pelvis imaging in order to help identify possible COVID-19 patients. Early identification of these patients would lead to optimal treatment strategies for the patient and protection for staff members. However, an extension of CT would be associated with increased irradiation doses for the patient, and its diagnostic relevance was unclear. Methods: This was a retrospective observational review looking at all surgical admissions that required a CT Thorax/Abdomen/Pelvis across 7 weeks during the COVID-19 pandemic, across four Scottish Hospitals. CT thorax investigations (of non-surgical patients) were also re-assessed by a single radiologist to assess the extent of pathology identified at the lung bases (and therefore would be included in a standard CT abdomen and pelvis). Results: Of 216 patients identified who had a CT thorax/Abdomen/Pelvis during the timeframe, 5 were diagnosed with COVID-19. During this timeframe, 77 patients underwent solely CT thorax. Across the entire cohort, 98% of COVID pathology was identified at the lung bases. The estimated sensitivity and specificity of CT thorax was 60 and 86.4% respectively. Conclusions: In a region with relatively low prevalence of SARS-COV2 infection, inclusion of CT Thorax in surgical admission imaging does not significantly contribute to identification and management of SARS-COV2 patients. We therefore suggest that imaging the lung bases can be sufficient to raise clinical suspicion of COVID-19. Advances in knowledge: This paper adds further evidence to that from other single UK centres that the addition of CT chest for all patients does not yield any further diagnostic information regarding coronavirus. Additionally, rapid SARS-CoV-2 testing in the UK (which is currently widely available) further demonstrates that inclusion of the entire chest during CT examination of the acute abdomen is not required.
Clinical effect of Zoledronic Acid in the treatment of Senile Osteoporosis
Authors: Kong Li , Zuo Kai , Ma Long 
Published: October 2020

Objective: To investigate the clinical efficacy of zoledronic acid in the treatment of senile osteoporosis.
Methods: One hundred and six cases of senile osteoporosis who visited to our hospital from August 2017 to December 2018 for treatment were selected and randomly divided into a control group and an observation group. The control group was treated with conventional therapy, while the observation group was treated with zoledronic acid in addition to the treatment of the control group. Bone mineral density, pain degree, therapeutic effect and adverse reactions of the two groups were compared.
Results: The total effective rate of the observation group was 96.67%, higher than 80.00% of the control group (P<0.05); the bone mineral density of lumbar vertebrae, femoral neck and Ward’ area in the two groups increased after 6 months of treatment, and the bone mineral density of the observation group increased more than that of the control group (P<0.05); the pain degree of the observation group was lower than that of the control group after 6 months of treatment, and the difference was significant (P<0.05). There was no significant difference in the occurrence of adverse reactions between the two groups (P>0.05).
Conclusion: Zoledronic acid is helpful to alleviate clinical symptoms, reduce the degree of bone pain, and promote the increase of bone mass, and has high safety in the treatment of senile osteoporosis, which is worth promotion.
doi: https://doi.org/10.12669/pjms.36.7.1964
How to cite this:Kong L, Zuo K, Ma L. Clinical effect of Zoledronic Acid in the treatment of Senile Osteoporosis. Pak J Med Sci. 2020;36(7):1703-1707. doi: https://doi.org/10.12669/pjms.36.7.1964
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A study protocol for quantifying patient preferences in neuromuscular disorders: a case study of the IMI PREFER Project
Authors: Jimenez-Moreno Aura Cecilia , Pinto Cathy Anne , Levitan Bennett , Whichello Chiara , Dyer Christine , Van Overbeeke Eline , de Bekker-Grob Esther , Smith Ian , Huys Isabelle , Viberg Johansson Jennifer , Adcock Kate , Bullock Kristin , Soekhai Vikas , Yuan Zhong , Lochmuller Hanns , de Wit Ardine , Gorman Grainne S. 
Published: October 2020

Objectives:Patient preference studies are increasingly used to inform decision-making during the medical product lifecycle but are rarely used to inform early stages of drug development. The primary aim of this study is to quantify treatment preferences of patients with neuromuscular disorders, which represent serious and debilitating conditions with limited or no treatment options available.Methods:This quantitative patient preferences study was designed as an online survey, with a cross-over design. This study will target two different diseases from the neuromuscular disorders disease group, myotonic dystrophy type 1 (DM1) and mitochondrial myopathies (MM). Despite having different physio-pathological pathways both DM1 and MM manifest in a clinically similar manner and may benefit from similar treatment options. The sample will be stratified into three subgroups: two patient groups differentiated by age of symptom onset and one caregivers group. Each subgroup will be randomly assigned to complete two of three different preference elicitation methods at two different time points: Q-methodology survey, discrete choice experiment, and best-worst scaling type 2, allowing cross-comparisons of the results across each study time within participants and within elicitation methods. Additional variables such as sociodemographic, clinical and health literacy will be collected to enable analysis of potential heterogeneity.Ethics and Dissemination:This study protocol has undergone ethical review and approval by the Newcastle University R&D Ethics Committee (Ref: 15169/2018). All participants will be invited to give electronic informed consent to take part in the study prior accessing the online survey. All electronic data will be anonymised prior analysis. This study is part of the Patient Preferences in Benefit-Risk Assessments during the Drug Life Cycle (IMI-PREFER) project, a public-private collaborative research project aiming to develop expert and evidence-based recommendations on how and when patient preferences can be assessed and used to inform medical product decision making.
When the Stars Shine Too Bright: The Influence of Multidimensional Ratings on Online Consumer Ratings
Authors: Schneider Christoph , Weinmann Markus , Mohr Peter N.C. , vom Brocke Jan 
Published: October 2020

Scholars generally assume that consumer ratings reflect consumer satisfaction, but ratings can be influenced by the design of the rating system. We examine two rating designs—single-dimensional rating systems, which elicit overall ratings only, and multidimensional (MD) rating systems, which elicit both dimensional and overall ratings—and how they impact overall ratings. Drawing on the accessibility–diagnosticity framework, we argue that dimensional ratings in MD systems influence overall ratings based on how the dimensions have been rated. We support this explanation with seven experiments. Our results suggest that across various experimental settings, rating objects, dimensions, and numbers of dimensions, overall ratings are systematically influenced by the design of the rating system.This paper was accepted by Chris Forman, information systems.
Escape room educativa: Concepción de los futuros maestros de Educación Secundaria en especialidad de Educación Física y Tecnología sobre la experiencia de diseñar y participar en una escape room educativa
Authors: Lopez Secanell Irene , Ortega Torres Enric 
Published: October 2020

En los últimos años se ha incrementado el interés por metodologías alternativas e innovadoras que poco a poco se van implementando en las aulas. Dentro de estas metodologías encontramos la gamificación, con un componente lúdico y motivacional que paulatinamente ha ganado terreno en el ámbito educativo. Conscientes de ello, en el presente artículo se analiza la concepción de los futuros profesores de educación secundaria en especialidad de educación física y tecnología sobre la experiencia de diseñar y participar en una Escape Room educativa. Para ello se muestra las propuestas didácticas desarrolladas en ambas materias y los resultados obtenidos de un cuestionario realizado con Google Forms. Los resultados muestran como los estudiantes valoran positivamente la experiencia de participar y diseñar una Escape Room a nivel educativo y ven viable su futura aplicación en el aula. Se muestra un ejemplo de investigación-acción que permite concluir la necesidad de transformar la formación inicial docente a través de estrategias como la gamificación y abrir líneas de investigación que apuesten por Escape Rooms inter y transdisciplinares.
La concepción de la gramática subyacente en las evaluaciones en la Suiza francófona
Authors: Sánchez Abchi Verónica , De Pietro Jean-François 
Published: October 2020

Este artículo se propone analizar la concepción de la enseñanza de la gramática que emerge de las prácticas de evaluación certificativa utilizadas en la parte francófona de Suiza. Asimismo, nos interesamos por la manera en que las evaluaciones se relacionan con los documentos de referencia oficiales que orientan la enseñanza obligatoria. En este sentido, analizamos 6 pruebas cantonales, dirigidas a todos los alumnos de 8H (alumnos de 11/12 años) de los cantones francófonos, teniendo en cuenta diferentes criterios: el espacio atribuido a la gramática en las pruebas, los contenidos movilizados, la relación con el texto, las acciones requeridas y la tipología de las preguntas. Las pruebas muestran que, aunque existe una base común de contenidos evaluados en todos los cantones, los diferentes formatos y las acciones requeridas se relacionan con distintas concepciones de la gramática. Asimismo, las operaciones y contenidos ausentes de las evaluaciones sugieren, igualmente, que estos no son priorizados en las aulas. Finalmente, las restricciones de las prácticas de corrección a gran escala tienen también consecuencias en la realización de las preguntas e, indirectamente, en la concepción de la gramática que se pone en juego. Las evaluaciones evidencian no una, sino diversas concepciones de la gramática, que reflejan parcialmente los principios de los documentos oficiales.
O impacto da obra de Nelson Traquina nos Estudos em Jornalismo do Brasil
Authors: Meditsch Eduardo , Neto Guilherme Guerreiro 
Published: October 2020

Este artigo analisa o impacto da obra de Nelson Traquina nos Estudos em Jornalismo realizados no Brasil, a partir de estudos bibliométricos em trabalhos apresentados em congressos de Jornalismo e Comunicação no país. Para isso, recupera resultados de estudos publicados anteriormente e apresenta novos dados, produzidos especialmente para este paper, relativos a trabalhos apresentados em eventos de 2019, numa pesquisa sincrônica, e ao longo de duas décadas (2000-2019), numa perspectiva diacrônica. Da análise conjunta destes dados, conclui que Nelson Traquina, ao longo de todo esse período, foi um autor com alto impacto na pesquisa brasileira em Jornalismo, sendo que mais recentemente, o impacto de seu trabalho autoral tornou-se mais significativo do que o observado em seus trabalhos de divulgador, para a Língua Portuguesa, da literatura internacional dos Journalism Studies. Comparados os congressos que reúnem pesquisadores com nível de pós-graduação e graduação realizados em 2019 no Brasil, o impacto da obra de Traquina é maior na pesquisa de pós-graduação.
Potensi Vegetasi Hutan Mangrove untuk Mitigasi Intrusi Air Laut di Pulau Kecil
Authors: Damayanti Cahya , Amukti Rian , Suyadi Suyadi 
Published: October 2020

<strong>Mangrove Forest Vegetation Potency to Mitigate Seawater Intrusion on Small Island. </strong>Natural resources exploitation in the coastal areascaused serious problems for shallow ground wateravailabily especially in small islands. Small islands society such as in Ambon Island facesdrinking water quality degradation due to the sea water intrusion.Mangrove is one of the coastal ecosystemtypesthatis though to minimize sea water intrusion.However, the information about mangroveparametersthat can be used todetermine the mangrove forest patches potency in small islands to mitigate sea water intrusion is still limited. The aim ofthis study is to assess the correlationof mangrove vegetation and sea water intrusion using transect anddipole-dipole configuration geoelectric methods. The study showed that the thickness of mangrove vegetation and the size of mangrove trees determined the mangrove forest potencyto mitigatesea water intrusion.There was no sea water intrusion (relativity values:75.5-118 Wm)in Passo, due to thick mangrove vegetation (mean:320 m) and bigmangrove tree sizes (mean diameter: 19cm and mean height: 10m).Sea water intrusion was low (relativity values: 0.798-4.53Wm)in Poka due to thin mangrove vegetation (mean 10-100 m) and small tree sizes(mean diameter: 8.6cm and mean height: 5m). In contrasts, sea water intrusion was very high (relativity values: 1.4-9.2Wm) for the areas without mangrove vegetation(e.g. Lateri). These mangrove parameters were also negatively correlated with the distribution and coverage area of sea water intrusion.Mangrove patches in small islands can be used assea water intrusion mitigation tools, but theecosystem condition was already degraded or in the poor conditions. The findings of this study are useful for government as a basis in decision makingand to better manage of ground water and coastal ecosystem particularly mangrove.