bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Pharmacology-based Prediction of Mechanism of Shenzhuo Formula for Application to DN
Authors: Wang Xin-miao , Han Lin , Zhang Li-li , Di Sha , Wei Xiu-xiu , Wu Hao-ran , Zhang Hai-yu , Yang Hao-yu , Zhao Lin-hua , Tong Xiaolin 
Published: August 2020

Abstract
Background: Shenzhuo formula is a traditional Chinese medicine (TCM) prescription which has significant therapeutic effects on diabetic nephropathy (DN). However, its mechanism remains unknown. Therefore, this study aimed to explore the underlying anti-DN mechanism of shenzhuo formula.Methods: The active ingredients and targets of shenzhuo formula were obtained by searching TCMSP, TCMID, SwissTargetPrediction and HIT. The DN target was identified from TTD, DrugBank and DisGeNet. The potential targets were obtained and PPI network were built after mapping the disease and drug targets. The key targets were screened out by network topology and the “drugs - DN - key targets” network was constructed by Cytoscape. GO analysis and KEGG pathway enrichment analysis were performed using DAVID, and the results were visualized using the Omicshare Tools.Results: We obtained 182 potential targets and 30 key targets. Ulteriorly, “drugs - DN - key targets” network were constructed, and results showed that nodes like M51, M21, M5, M71, M28, EGFR, MMP9, MAPK8, PIK3CA and STAT3 had a higher degree. GO analysis results mainly involved in positive regulation of transcription from RNA polymerase II promoter, inflammatory response, lipopolysaccharide-mediated signalingpathway and other biological processes. The results of KEGG showed that DN-related pathways like TNF signaling pathway, PI3K-Akt signaling pathway were at the top of the list.Conclusion: This article reveals the possible mechanism of shenzhuo formula in the treatment of DN through network pharmacology research, and lays a foundation for further studies.
Adult Patients’ Motivations and Expectations of Orthodontic Treatment: A Systematic Review Protocol
Authors: Qian Yajing , Yuan Siyang , Humphris Gerald , Freeman Ruth 
Published: August 2020

Abstract
Background: This is a protocol for a systematic review of the motivations and expectations of adult patients who seek orthodontic treatment. With the continuous improvement of orthodontic technique and rapid innovation of orthodontic appliances, more adults begin to consider orthodontic treatment. Appropriate motivations and realistic expectations play an important role towards a desired goal that are thought to increase patients’ cooperation and achieve satisfaction with treatment outcome. This review aims to assess the motivations and expectations of adult patients who seek orthodontic treatment and investigate how their motivations and expectations affect their satisfaction with treatment outcomes.Methods: A systematic search will be undertaken to map and screen the literature on adult patients’ motivations and expectations of orthodontic treatment and their effects on satisfaction of treatment outcome. Papers written in English or Chinese with no study design restrictions will be included. The study of adolescent patients or patients’ parents, patients with craniofacial hypoplasia and orthodontic treatment combined with orthognathic surgery will be excluded. If quantitative synthesis is possible, a meta-analysis will be conducted. Discussion: This systematic review will identify and gather evidence on adult patients’ motivations and expectations of orthodontic treatment. The method orthodontists obtain and assess adult patients’ motivations and expectations will be discussed. Accurate obtaining and appropriate managing adult patients’ motivations and expectations may increase the cooperation during treatment and satisfaction of the treatment outcome.Systematic review registration: PROSPERO CRD42020185022
Health Disparities of Critically Ill Children in Poverty: A Nationwide Population-Based Study
Authors: Park Esther , Park Hyejeong , Kang Danbee , Chung Chi Ryang , Yang Jeong Hoon , Jeon Kyeongman , Guallar Eliseo , Cho Juhee , Shu Gee Young , Cho Joongbum 
Published: August 2020

Abstract
Background: There is a lack of nationwide studies on health disparity of critically ill patients under the National Health Insurance (NHI) System. We aim to evaluate health disparities in intensive care unit (ICU) admission, outcomes, and readmission after ICU discharge in an impoverished pediatric population.Methods: We conducted a retrospective cohort study using a national database of claims submitted to the Korean NHI and Medical Aid Program (MAP). MAP provides support for the population whose household income is lower than 40% of the median Korean household income, and we defined poverty as being a MAP beneficiary. Patients between 28 days and 18 years old who were admitted to the ICU between August 1, 2010 and September 30, 2013, were included. Demographic characteristics, procedures, admission rates, and clinical outcomes were compared between the poverty and reference groups. Logistic regression model used to analyze hospital mortality and readmission with adjustment for patient characteristics, hospital type, and management procedures.Results: Out of 17,893 patients, 1,153 (6.4%) patients were in poverty. The age-standardized ICU admission rate was higher in the poverty group (126.9 vs. 80.2 per 100,000 person-years). There were more deaths among impoverished patients who were admitted to the ICU (11.8 vs. 4.3 per 100,000 person-years). Patients in the poverty group had a similar risk of adjusted in-hospital mortality to those not in the poverty group (odds ratio: 1.15, confidence interval [CI]: 0.84–1.55) but a higher readmission rate (hazard ratio 1.25, CI 1.09–1.42).Conclusion: Pediatric patients in poverty were more likely to die in association with ICU admission. A high ICU admission rate rather than the high in-hospital mortality rate may cause the disparity in deaths. Further policies and studies are required to improve the health status of pediatric patients in poverty to decrease ICU admission.Trial registration: retrospectively registered
Trends of Interventional Radiology procedures during the Covid-19 pandemic: The first 27 weeks in the eye of the storm
Authors: How Guo Yuan , Pua Uei 
Published: August 2020

Abstract
ObjectivesWhile the Novel Coronavirus (COVID-19) pandemic looks to persist, institutions promote delaying procedures. Understanding trends and demands of interventional radiology (IR) procedures in the infected and COVID-free populations are needed in long-term planning. We detail IR procedure trends in the first 27 weeks of the pandemic and compare with the pre-pandemic era. MethodsIn this IRB approved retrospective electronic case review, all IR patients in our institution from 1 January to 9 July 2020, the same period in 2019 pre-pandemic and the Severe Acute Respiratory Syndrome (SARS-CoV) outbreak were included. IR procedures were classified using Interventional Radiology – Procedure Acuity Scale (IR-PAS) and category of IR procedures. Along with descriptive frequencies, the Mann-Whitney U test and Chi-square test of independence were performed.ResultsDuring the pandemic, 3655 IR procedures were performed compared to 3851 procedures pre-pandemic. No statistically significant difference in weekly IR caseloads across IR-PAS tiers between both periods (p = .088) and category of procedure (p = .054) were noted. General intervention procedures remained the largest proportion and musculoskeletal procedures the minority, in both periods. More general intervention radiology and oncology procedures were performed during the Covid-19 pandemic compared to the SARS-CoV outbreak. Thirty-four (0.93%) IR procedures were performed on 30 COVID-19 patients. There was no IR procedure-related COVID-19 cross-transmission. ConclusionsDemand for IR procedures among COVID-free patients remains high, and IR procedures involving COVID-19 represents a fraction of the IR caseload. A sustainable model in providing timely IR services to COVID-free patients needs to be considered.
Italian University Museums at Time of Covid-19 Lockdown: How to Restore a “Sense of Normalcy”
Authors: Magliacani Michela , Sorrentino Daniela 
Published: August 2020

Abstract
The COVID-19 pandemic has had a dramatic impact on the normal conditions within which Higher Education systems are used to operate. This regards not only teaching and research, but also public engagement activities as a university Third Mission. As for the latter, there is scant literature on University Museums as subjects that transfer cultural knowledge to the community, so providing a relevant public service. Addressing this research gap, this study focuses on the critical Italian context, exploring how University Museums have responded to the COVID-19 lockdown. To this aim, the social science notion of resilience is adopted for interpreting the evidence on their ability to cope with the emergency. Data from legislative and statistical sources are complemented by a questionnaire administered to 34 University Museums. Findings show the ability of Italian University Museums to handle the ongoing emergency by carrying out digital and non-digital activities that prevent it to become worse. A conceptual model that highlights how University Museums contribute to transfer cultural knowledge also at a time of emergency is finally proposed.
Gender Difference in Predisposing Factors of Overdose
Authors: Tan Sheng-Teck , Lo Chih-Hung , Liao Chen-Hao , Su Yu-Jang 
Published: August 2020

Abstract
Background Drug overdose is a one of common situations in emergency department (ED). We investigate gender difference and predisposing factors of overdose in emergency department (ED).Materials and Methods We retrospectively analyzed overdose reports from January 2018 to August 2019. We selected study cases by the ICD-10 coding system which include T36 to T50. A total of 299 overdose reports were collected during this period. Data were collected including Glasgow coma scale and vital signs on arrival (including body temperature, heart rate, systolic blood pressure, and diastolic blood pressure, gender, age, marital status, arrival time, season on admission, previous suicide attempts, psychiatric history, related comorbidities, recent argues, categories of overdose with or without concurrent ethanol use, length of hospital stay and survival to discharge were analyzed.Results The 196 enrolled patients ranged in age from 14 to 92 years (mean ± standard deviation (S.D.): 39.2 ± 18.3). Of them, male intentional overdose patients were 8.1 years older than female ones (45.3 ± 19.5 vs. 37.2 ± 17.5, respectively; p < 0.05)Conclusion The most top three kinds of substance overdose are benzodiazepine (42.9%), mixed medications (32.1%) and acetaminophen (6.1%). Physicians should notify the centers of suicide prevention to pay concern about who are middle-aged male, facing conflicts, especially in the spring.
Un algoritmo híbrido para resolver el problema de los valores propios cuadrático
Authors: Pérez Mera Rosana , Macías Caicedo Eduard Mauricio , Arenas Aparicio Favián Enrique 
Published: August 2020

El problema de los valores propios cuadráticos ha captado el interés de muchos investigadores debido a sus numerosas aplicaciones en áreas tales como mecánica de fluidos, Acústica e Ingeniería, entre otras. En este artículo se presenta un algoritmo híbrido para resolver este problema, el cual combina un algoritmo para el cálculo de soluciones de la ecuación cuadrática matricial con uno tradicional para el cálculo de valores propios. Se seleccionaron doce problemas de aplicación, en diversas áreas, para hacer un análisis comparativo del desempeño del algoritmo propuesto con el tradicional método de Newton-Schur. Como conclusión se determinó que la propuesta algorítmica es competitiva frente al método de Newton-Schur y más eficiente.
PENDAMPINGAN BELAJAR BAHASA INGGRIS MENGGUNAKAN MEDIA INTERAKTIF BAGI ANAK-ANAK DI PANTI ASUHAN USWATUN HASANAH PONTIANAK
Authors: Syahadati Elly , Kusumaningsih Citra , Anita Finny , Darajat Ageung 
Published: August 2020

<p>Pendampingan belajar bahasa Inggris menggunakan media interaktif yang dilaksanakan oleh Tim dosen Program Studi Pendidikan Bahasa Inggris IKIP PGRI Pontianak ini dilaksanakan di Panti Asuhan Uswatun Hasanah Pontianak. Tujuan dari kegiatan ini adalah untuk menumbuhkan minat dan daya tarik peserta dalam belajar Bahasa Inggris, diharapkan dengan menggunakan media interaktif, peserta dapat meningkatkan kemampuan mereka dalam menggunakan kosakata Bahasa Inggris dengan baik dan benar. Adapun media interaktif yang digunakan dalam pendampingan ini berupa <em>scrabble</em>. Pengumpulan data yang dipakai dalam kegiatan ini adalah: (1) soal tes unjuk kerja untuk mengukur jumlah penguasaan kosakata peserta. Tes dikerjakan peserta secara individual yang diberikan di akhir materi pembelajaran. dan (2) catatan lapangan, dilakukan dengan mendokumentasikan proses pembelajaran bahasa Inggris dan foto kegiatan selama proses belajar mengajar baik sebelum maupun ketika dilaksanakan tindakan. Berdasarkan kegiatan pendampingan yang telah dilaksanakan, dapat ditarik kesimpulan bahwa terdapat perubahan sikap peserta dari yang kurang aktif, tidak antusias dan kurang terlibat menjadi lebih aktif, antusias dan mau berinteraksi secara kolaborasi selama kegiatan pendampingan berlangsung sehingga terdapat peningkatan ketrampilan peserta dalam menguasai kosakata bahasa Inggris.</p>
PELATIHAN PENULISAN KARYA TULIS ILMIAH KEPADA GURU SMP SE-KOTA PONTIANAK
Authors: Alimin Al Ashadi , Hartati Mesterianti , Simarmata Mai Yuliastri 
Published: August 2020

<p>Tujuan pelatihan dalam kegiatan PKM ini adalah; terlaksananya pelatihan penelitian tindakan kelas, menambah pemahaman guru terhadap karya tulis ilmiah berupa penelitian tindakan kelas, dan diperoleh rencana judul yang nantinya dapat dikembangkan oleh guru-guru menjadi suatu bentuk penelitian tindakan kelas. Kegiatan pengabdian kepada masyarakat (PKM) dilakukan oleh tim dosen Program Studi Pendidikan Bahasa dan Sastra Indonesia IKIP PGRI Pontianak yang ditujukan kepada guru SMP Se-Kota Pontianak yang tergabung dalam MGMP bahasa Indonesia tingkat SMP Kota Pontianak yang berjumlah 40 orang peserta. Kegiatan dilaksanakan dalam dua bentuk kegiatan yaitu (1) metode ceramah dan tanya jawab digunakan untuk menjelaskan teori mengenai karya tulis ilmiah serta penelitian tindakan kelas, (2) metode simulasi dan metode praktik digunakan untuk tahap kegiatan pelatihan yang menitikberatkan pada kemampuan melaksanakan penelitian tindakan kelas. Keberhasilan kegiatan diukur menggunakan dua cara yaitu (1) angket respon peserta terhadap materi yang disajikan, (2) Proposal PTK yang ditulis oleh peserta pelatihan. Selama pelasanaan kegiatan materi yang disampaikan dapat diterima dengan baik oleh peserta, akan tetapi karena keterbatasan waktu peserta pelatihan belum optimal dalam praktik tahapan pelaksanaan PTK</p>
KAJIAN BANYAKNYA PUPUK KANDANG TERHADAP PERKEMBANGAN DAPHNIA (Daphnia sp.) DI RUMAH KACA
Authors: Wardoyo Supriyono Eko , Sugiarti Lilis , Setyawan Teddy 
Published: August 2020

Study On The Effect Of Chicken Manure On Daphnia Developmnt In A Greenhouse. Daphnia is a zooplankton that used as a natural food for fishes, having complete nutrient, easily digested by fishes because Daphnia having thin skin. Besides, natural food generally doesn’ make lower water-media quality and make more desease resistance of fishes. Study methode was having 8 treatments that were 0,1,2,3,4,5,6,and 7 g/l of dry chicken manure that immersed in each 30 l aquarium in 3 replicats, placed in a green house. Average of 225 Daphnias were stocked in each aquarium. Statistical experimental design of the study was the Completely Random Design (CRD).Study results showed that mximum number of Daphnia after 6 days was at chicken manure of 3 g/l that was 344,000 Daphnias/30l aquarium. Average water-media temperature in 6 days was 33oC , and water pH was 6.45. There was negative correlation significntly between Daphnia development and pH, but no correlation that one with temperature.Keywords : Daphnia, manure, pH, temperature, and green house Abstrak Daphnia adalah zooplankton yang digunakan sebagai pakan alami ikan, yang mempunyai kandungan gizi yang lengkap, mudah dicerna dalam saluran pencernaan karena isinya padat dan mempunyai dinding yang tipis, selain itu tidak menyebabkan penurunan kualitas air media, dan dapat meningkatkan daya tahan benih ikan terhadap penyakit. Metoda yang digunakan yaitu dengan mencoba 8 perlakuan 0,1, 2, 3, 4, 5, 6, 7, g/l pupuk kandang kotoran ayam kering yang diaplikasikan dalam akuarium volume 30 l dengan 3 ulangan dalam rumah kaca. Jumlah Daphnia ditebar, sebanyak 225 ekor per akuarium. Rancangan statistik yang dilakukan adalah dengan Rancangan acak lengkap (RAL). Hasil penelitian menyatakan bahwa jumlah Daphnia tertinggi pada hari keenam adalah pada konsentrasi pupuk 3 g/l yaitu 344.000 ekor. Kualitas air selama penelitian adalah rata-rata suhu air 33 °C dan rata-rata pH 6,45 serta kualitas air ini merupakan kondisi optimum untuk pertumbuhan Daphnia di rumah kaca. Ada korelasi negatif (berlawanan) secara nyata antara rata-rata perkembangan Daphnia dengan pH, tetapi tidak ada korelasi antara perkembangan Daphnia dengan suhu air.Kata kunci : Daphnia, konsentrasi pupuk , pH, suhu air, rumah kaca
ANALISIS KERAGAMAN GENETIK TIGA STRAIN NILA MERAH (Oreochromis sp) DENGAN ANOVA RAPD
Authors: Iskandariah Iskandariah , Arifin Otong Zenal , Gustiano Rudhy 
Published: August 2020

Analysis Genetic Variation of Three Strains of Red Tilapia by Anova of RAPD. Study on the genetic variance of three strains of red tilapia (Oreochromis sp) had been conducted in the Biology Molecular Laboratory, Research Institute for Freshwater Aquaculture (RIFA) Bogor. Three different strains, Red NIFI from Thailand, Red Tilapia from Lido lake and Red Tilapia from Bogor’s farmer were analyzed in the study. Observation used Random Amplified Polymorphism DNA (RAPD) with OPA-03, OPA-04, OPC 14 and OPC-15 primers. The results showed that only OPA-03 primer was able to amplify numerous samples. Further analysis showed that the percentage of polimorphic range was between 16.67 – 38.89%, heterozygosity value 0.0378 – 0.1536 and genetic distance among strain 0.3051 – 0.6037.Keywords : RAPD, genetic, strain, nile tilapia, oreochromis ABSTRAK Penelitian mengenai variasi genetik tiga strain nila merah dari 3 lokasi yang berbeda telah dilakukan di Laboratorium Molekuler Biologi, Balai Riset Perikanan Budidaya Air Tawar (BRPBAT) Bogor. Strain yang diamati meliputi jenis nila Red NIFI dari Thailand, nila merah dari Danau Lido dan nila merah dari Petani Bogor. Penelitian menggunakan metode analisis Random Amplified Polymorphism DNA (RAPD), dengan menggunakan primer OPA-03, OPA-04, OPC-14 dan OPC-15. Hasil pengamatan menunjukkan hanya OPA-03 yang dapat menghasilkan amplifikasi dalam jumlah sampel yang memadai. Hasil analisis menunjukkan bahwa persentase polimorfik berkisar antara 20.00-40.00%, dengan nilai heterozigositas 0.0604–0.1516 dan jarak genetik antar strain 0.1770-0.4865. Kata kunci : RAPD, genetik, strain, ikan nila, oreochromis
UJI CEMARAN BAKTERI DAN CENDAWAN PADA KEJU KASAR (Cheddar)
Authors: Srikandi Srikandi 
Published: August 2020

Contamination Test of Bacteria and Fungi on Rough Cheese (Cheddar) Foodstuffs such as cheese as a source of nutrition for humans, is also a food source for microorganisms. The growth of microorganisms in foodstuffs can cause adverse or beneficial change. Quality cheese can be seen from the presence of bacteria and mildew stains on the cheese samples. This study aimed to determine quantitatively the presence of bacteria and fungi in ten samples of coarse cheese (Cheddar) from five traditional markets in Bogor. Testing performed at the microbiology laboratory a contamination of bacteria of Salmonella sp and Listeria monocytogenes and yeast. The research results from ten samples of coarse cheese (Cheddar) had stain of pathogenic bacteria of Listeria monocytogenes and Salmonella sp Based on standar method of SNI 19-2897 – 1992 was negative/25g of sampel or mold and yeast was <10 cfu / g. Sample Zt was concluded that no contamination and Save to be consumend. Key words : Cheese (Cheddar), Bacteri and Fungi ABSTRAK Bahan makanan seperti keju selain merupakan sumber gizi bagi manusia, juga merupakan sumber makanan bagi mikroorganisme. Pertumbuhan mikroorganisme dalam bahan pangan dapat menyebabkan perubahan yang merugikan atau menguntungkan. Kualitas keju dapat dilihat dari keberadaan cemaran bakteri dan cendawan, pada sampel keju. Penelitian ini bertujuan untuk mengetahui secara kuantitatif keberadaan bakteri dan cendawan pada sepuluh sampel keju kasar (Cheddar) dari lima pasar tradisional di Bogor. Pengujian dilakukan di laboratorium mikrobiologi berupa uji cemaran bakteri Salmonella sp, Listeria monocytogenes dan cendawan. Data hasil penelitian dari sepuluh sampel keju kasar (Cheddar) diantaranya untuk cemaran bakteri patogen Salmonella sp dan Listeria monocytogenes berdasarkan metode SNI 19-2897-1992 hasilnya yaitu negatif/25g serta kapang dan khamir hasilnya < 10 cfu/g sehingga nilai cemaran mikroba dikatan memenuhi standar dan layak untuk dikonsumsi.Kata kunci : Keju (Cheddar), Bakteri dan Cendawan
PEMBUATAN MINYAK KELAPA MENGGUNAKAN KULIT NANAS
Authors: Hutagaol Ricson P. , Santi Nina Maria 
Published: August 2020

The Making of Coconut Oil Using a Pineapple Skin The aim of this research was to find the right formula and making more quantity of coconut oil with fermentation method. In this research coconut milk that used was cream. The cream was mixed withs pineapple skin juice. Research was done the pre test to choose the optimum concentration, temperature and incubation time. The optimum condition produced was used to process of making coconut oil. The optimum concentration oil produced was 1: 1 at 65oC in 24 hours of incubation. Results of making coconut oils got the volume of 276 mL oil besides, thats oil was produced from cream without pineapple skin as the blank, that was produced 100mL oil. Coconut oil with pineapple skin had been analysed and having: Water content 0.5873%, waste 1.24%, free fat acid 2.31, iod number 8.51, saponification number 258.02, peroxidase number 0.591, negative pelican oil, negative heavy metal, normal organoleptic test.Based on this research could be concluded that coconut oil with pineapple skin entered to standard SNI 012902-1992.key words: coconut milk, cream, fermentation, pineapple skin ABSTRAK Penelitian ini bertujuanuntuk memperoleh formula yang tepat dalam pembuatan minyak kelapa secara fermentasi sehingga diperoleh minyak kelapa dalam jumlah banyak. Pada penelitian ini santan yang dimanfaatkan adalah krim. Krim santan yang digunakan dicampur dengan jus kulit nanas. Dilakukan uji pendahuluan pemilihan konsentrasi, suhu dan waktu inkubasi, Kondisi optimum yang didapat selanjutnya dipakai untuk proses pembuatan minyak kelapa. Dari uji pendahuluan yang telah dilakukan maka didapatkan konsentrasi optimum untuk pembuatan minyak kelapa adalah 1:1 pada suhu 650C dengan waktu inkubasi 24 jam. Hasil penelitian pembuatan minyak kelapa menunjukkan bahwa volume minyak yang diperoleh 276 mL, selain itu juga dilakukan pembuatan minyak dengan menggunakan krim tanpa jus kulit nanas yang disebut dengan blanko, pada blanko minyak yang didapat adalah 100 mL. Minyak kelapa dengan kulit nanas yang didapat dilakukan analisis kimia minyak kelapa yaitu: kadar air 0.5873%, kadar kotoran 1.24%, asam lemak bebas 2.31, bilangan iod 8.51, bilangan penyabunan 258.02, bilangan peroksida 0.591, minyak pelikan negatif, logam berbahaya negatif, dan uji organoleptik normal. Berdasarkan hasil penelitian dapat diambil kesimpulan bahwa minyak kelapa yang dihasilkan dengan menggunakan kulit nanas masuk standar SNI 012902-1992.Kata Kunci: Santan kelapa, krim, fermentasi, dan kulit nanas