bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotyping Reveals Targets of a Pseudo‐Natural‐Product Autophagy Inhibitor
Authors: Foley Daniel J. , Zinken Sarah , Corkery Dale , Laraia Luca , Pahl Axel , Wu Yao‐Wen , Waldmann Herbert 
Published: February 2020

AbstractPseudo‐natural‐product (NP) design combines natural product fragments to provide unprecedented NP‐inspired compounds not accessible by biosynthesis, but endowed with biological relevance. Since the bioactivity of pseudo‐NPs may be unprecedented or unexpected, they are best evaluated in target agnostic cell‐based assays monitoring entire cellular programs or complex phenotypes. Here, the Cinchona alkaloid scaffold was merged with the indole ring system to synthesize indocinchona alkaloids by Pd‐catalyzed annulation. Exploration of indocinchona alkaloid bioactivities in phenotypic assays revealed a novel class of azaindole‐containing autophagy inhibitors, the azaquindoles. Subsequent characterization of the most potent compound, azaquindole‐1, in the morphological cell painting assay, guided target identification efforts. In contrast to the parent Cinchona alkaloids, azaquindoles selectively inhibit starvation‐ and rapamycin‐induced autophagy by targeting the lipid kinase VPS34.
Deoxyfluorination with CuF2: Enabled by Using a Lewis Base Activating Group
Authors: Sood D. Eilidh , Champion Sue , Dawson Daniel M. , Chabbra Sonia , Bode Bela E. , Sutherland Andrew , Watson Allan J. B. 
Published: February 2020

AbstractDeoxyfluorination is a primary method for the formation of C−F bonds. Bespoke reagents are commonly used because of issues associated with the low reactivity of metal fluorides. Reported here is the development of a simple strategy for deoxyfluorination, using first‐row transition‐metal fluorides, and it overcomes these limitations. Using CuF2 as an exemplar, activation of an O‐alkylisourea adduct, formed in situ, allows effective nucleophilic fluoride transfer to a range of primary and secondary alcohols. Spectroscopic investigations have been used to probe the origin of the enhanced reactivity of CuF2. The utility of the process in enabling 18F‐radiolabeling is also presented.
Azahelicene‐Fused BODIPY Analogues Showing Circularly Polarized Luminescence
Authors: Maeda Chihiro , Nagahata Keiji , Shirakawa Takuma , Ema Tadashi 
Published: February 2020

AbstractHelical carbazole‐based BODIPY analogues were readily synthesized via aza[7]helicenes. The structures of azahelicene‐incorporated BF2 dyes were elucidated by x‐ray diffraction analysis. DFT calculations revealed that the π‐conjugated system expanded from the helicene moiety to the BODIPY framework. The azahelicene‐fused boron complexes showed the Cotton effects and the circularly polarized luminescence (CPL) in the visible region. Furthermore, an axially chiral binaphthyl group was attached to the helically chiral dyes, which enhanced the chiroptical properties.
Thermo‐Responsive MOF/Polymer Composites for Temperature‐Mediated Water Capture and Release
Authors: Karmakar Avishek , Mileo Paulo G. M. , Bok Ivan , Peh Shing Bo , Zhang Jian , Yuan Hongye , Maurin Guillaume , Zhao Dan 
Published: February 2020

AbstractWe report an in situ polymerization strategy to incorporate a thermo‐responsive polymer, poly(N‐isopropylacrylamide) (PNIPAM), with controlled loadings into the cavity of a mesoporous metal–organic framework (MOF), MIL‐101(Cr). The resulting MOF/polymer composites exhibit an unprecedented temperature‐triggered water capture and release behavior originating from the thermo‐responsive phase transition of the PNIPAM component. This result sheds light on the development of stimuli‐responsive porous adsorbent materials for water capture and heat transfer applications under relatively mild operating conditions.
Advances in Understanding Mechanisms of Perovskites and Pyrochlores as Electrocatalysts using In‐Situ X‐ray Absorption Spectroscopy
Authors: Park Joohyuk , Cho Jaephil 
Published: February 2020

AbstractMetal oxides are some of the most promising candidates as electrocatalysts for electrical‐energy‐storage (EES) systems. Particularly, perovskite and pyrochlore oxides have been intensively investigated as bifunctional electrocatalysts because of their superior catalytic activities during the oxygen‐reduction and ‐evolution reactions. However, the origin of the outstanding catalytic activities and structural changes of the materials are not clear, in part due to the difficulty in identification during electrocatalysis. In this Minireview, we present a critical overview of recent progress in understanding catalytic mechanisms of perovskite and pyrochlore oxides, highlighting the innovative in‐situ X‐ray absorption spectroscopy (XAS) analysis for electrochemical tests.
GxE Effects on Tocopherol Composition of Oils from Very Old and Genetically Diverse Olive Trees
Authors: Rodrigues Nuno , Casal Susana , Cruz Rebeca , Peres António M. , Baptista Paula , Pereira José A. 
Published: February 2020

AbstractTocopherols are compounds with high biological activity, beneficial for human health that can be found in vegetable oils like olive oil, contributing for its resistance to oxidation. In this work, the tocopherol contents of olive oils extracted from centenarian olive trees of six cultivars (cvs. Lentisca, Madural, Rebolã, Redondal, Verdeal, and Verdeal Transmontana) were evaluated during five consecutive crop seasons (2013–2017). Three tocopherol isoforms (α‐, β‐ and γ‐tocopherols) were detected in all analyzed olive oils, and their content varied significantly with the cultivar and year of production. The highest amounts were found in cv. Lentisca (456 ± 122 mg/kg olive oil), while the lowest were observed in cv. Verdeal (179 ± 45 mg/kg olive oil). Crop year was the most influential factor, with the highest contents observed in 2013 and lowest in 2014. Principal component analysis and hierarchical clustering analysis helped differentiate olive oils according to cultivar or production year. These data suggest that tocopherol composition may serve as a chemical marker to distinguish the subject cultivar olive oils from centenarian trees either by olive cultivar or by crop year, being some cultivars identified as potential candidates for guaranteeing the production of olive oils rich in these compounds.
Making vinyl ester resin greener: Succinic acid–glycerol‐derived reactive diluent as an alternative to styrene
Authors: Jahandideh Arash , Moini Nasrin , Bajgholi Sara , Zohuriaan‐Mehr Mohammad Jalal , Kabiri Koroush 
Published: February 2020

AbstractA bio‐based reactive diluent (BRD) was synthesized from succinic acid and glycerol, and successfully copolymerized with epoxy acrylate (EA). Chemical structure of BRD was studied by nuclear magnetic resonance and Fourier transform infrared. The performance of vinyl ester resin compositions has been examined through differential scanning calorimetry, thermogravimetric analysis, and dynamic mechanical analysis, as well as tensile and flexural tests. Results demonstrated good compatibility between EA and the BRD. Compared to styrene, the BRD contribution of 50 wt% enhanced the elastic modulus (~40%). Samples copolymerized with BRD or styrene, have shown a similar thermal stability. Mechanical properties of cured blends, containing up to 25 wt% of BRD, found to be superior than styrene‐diluted compartments. Viscosities of EA–BRD blends were in range of 3.25–0.43 Pa/s at 30°C. Inexpensive bio‐based source, good thermomechanical and rheological properties, and great compatibility with EA are of advantages of these BRD‐containing formulations.
Population abundance and habitat preference of the Yangtze finless porpoise in the highest density section of the Yangtze River
Authors: Chen Minmin , Yu Daoping , Lian Yuxi , Liu Zhigang 
Published: February 2020

Abstract

Habitat loss and degradation together represent one of the five major factors contributing to the rapid decline of the Yangtze finless porpoise in the Yangtze River. Protecting key habitat patches and maintaining migration corridors between habitat patches are major conservation objectives to ensure the in situ viability of the Yangtze finless porpoise. Baseline information essential for addressing these two objectives includes that pertaining to distribution and habitat preference.
To investigate the distribution and habitat preferences of the Yangtze finless porpoise, five transect surveys were conducted in the Anqing section of the Yangtze River, which has the highest porpoise density among all sections of the river. Porpoise abundance estimates were calculated, and preferences for different habitat types were evaluated.
The calculated porpoise abundance in the Anqing section was 181 (95% CI 125–239) animals on average. The inter‐annual and inter‐seasonal differences in porpoise abundance estimates were not significant. The natural river banks and sandbar shores were the most preferred habitats, representing 46.3 and 29.8% of the porpoise observations, respectively. In contrast, 8.1% of the porpoises were observed in habitats along reinforced river banks, which account for 38.7% of the total coastline. In subsections with natural habitat patches, porpoises were observed in almost every survey, while porpoise occurrence became highly stochastic in subsections with long reinforced river banks. These results indicate a significant tendency of the Yangtze finless porpoise to prefer natural habitats with natural river bank or sandbars but to keep away from reinforced river‐bank habitats.
According to porpoise density in different subsections, free migration may be impeded or only one migration corridor remains in some subsections.
Although protecting finless porpoise habitats has become a primary conservation objective, this study highlights the need to protect frequently used habitat patches and migration corridors, particularly those near natural river banks and sandbars, and to restore ecological environments along reinforced river banks.
Implementation of a 23-h surgery model in a tertiary care hospital: a safe and feasible model with high patient satisfaction
Authors: Ruohoaho U-M , Toroi P , Hirvonen J , Aaltomaa S , Kokki H , Kokki M 
Published: February 2020

Abstract

Background
The 23-h surgery model consists of elective operative care with an overnight hospital stay for patients unsuitable for day case surgery. The aim of this study was to assess the success of the 23-h surgery model.

Methods
This was a prospective follow-up study of patients undergoing surgery with the planned 23-h model in a tertiary-care university hospital during a 12-month period 2 years after the model was implemented. Patients were interviewed 2 weeks after surgery, and the hospital operative database and patient records were searched. The primary outcome was the success of the process, defined as discharge before 10.00 hours on the first morning after surgery. Secondary outcomes were 30-day readmission and reoperation rates, adverse events, and patient satisfaction with the process.

Results
Between May 2017 and May 2018, 993 adult patients underwent surgery with the 23-h model, of whom 937 adhered to the model as planned (success rate 94·4 per cent). Gynaecological, gastrointestinal and orthopaedic surgery were the three most common surgical specialties. The surgical process was changed to an in-hospital model for 45 patients (4·5 per cent), and 11 (1·1 per cent) were discharged on the day of surgery. The readmission rate was 1·9 per cent (19 of 993), and five patients (0·5 per cent) had a reoperation within 30 days of surgery. Fifty-nine adverse events were noted in 53 patients (5·3 per cent), most commonly infection. Patient satisfaction was a median of 6–7 (maximum 7) points for various aspects of the model.

Conclusion
The success rate and patient satisfaction for the 23-h surgery model was high.
How an international ambidexterity strategy can address the paradox perspective on corporate sustainability: Evidence from Chinese emerging market multinationals
Authors: Ciasullo Maria Vincenza , Montera Raffaella , Cucari Nicola , Polese Francesco 
Published: February 2020

AbstractCorporate sustainability (CS) is receiving considerable attention from emerging market multinational enterprises (EMNEs), playing an important role in the globalized market. However, theoretical and empirical knowledge about how EMNEs address CS is still scant, and the relationship between internationalization and CS has not been widely explored. This study aims to fill this gap, evaluating the relationship between an international ambidexterity strategy and CS in EMNEs, which highlighted the paradox perspective. Then we develop three hypotheses in which we argue how the dynamic capabilities underpinning international ambidexterity could be considered a driver of CS in EMNEs. We test the developed hypotheses against data from 300 Chinese EMNEs obtained by a survey. Our results contribute to shape ambidextrous international strategies and to consider CS as a springboard for the strategic intent to systematically and recursively outperform global competition. Testing a measurement scale of international ambidexterity, we suggest structural ambidexterity as a strategic option of internationalization that allows the achievement of economic, social, and environmental sustainability objectives.
Innovative development of membrane sparger for carbon dioxide supply in microalgae cultures
Authors: Moraes Luiza , da Rosa Gabriel M. , Santos Lucielen O. , Costa Jorge A. V. 
Published: February 2020

AbstractThe present study was aimed to develop a membrane sparger (MS) integrated into a tubular photobioreactor to promote the increase of the carbon dioxide (CO2) fixation by Spirulina sp. LEB 18 cultures. The use of MS for the CO2 supply in Spirulina cultures resulted not only in the increase of DIC concentrations but also in the highest accumulated DIC concentration in the liquid medium (127.4 mg L−1 d−1). The highest values of biomass concentration (1.98 g L−1), biomass productivity (131.8 mg L−1 d−1), carbon in biomass (47.9% w w−1), CO2 fixation rate (231.6 mg L−1 d−1), and CO2 use efficiency (80.5% w w−1) by Spirulina were verified with MS, compared to the culture with conventional sparger for CO2 supply. Spirulina biomass in both culture conditions had high protein contents varying from 64.9 to 69% (w w−1). MS can be considered an innovative system for the supply of carbon for the microalgae cultivation and biomass production. Moreover, the use of membrane system might contribute to increased process efficiency with a reduced cost of biomass production.
Integrated practice effect analysis of teaching design pattern on TPACK
Authors: Guo Ping 
Published: February 2020

AbstractThe paper analyzes the university curriculum, including analysis of context, pedagogical content knowledge, technology technological content knowledge, and technological pedagogical knowledge with the technological pedagogical and content knowledge (TPACK) framework. By integrating classroom teaching with the TPACK framework, through the analysis of the effect of the teaching practice of three stages in four semesters, the following conclusions are drawn: (a) Proper teaching methods and teaching techniques will greatly expand the content of the textbook; (b) integrating TPACK framework requires teachers to have more extensive knowledge and strong organization capacity; (c) through TPACK integration, all kinds of new teaching methods and teaching technologies have plenty of time to use in the classes, and the new idea of educational technology will cause the emergence of educational technologies.
Real‐world data of lapatinib and treatment after lapatinib in patients with previously treated HER2‐positive metastatic breast cancer: A multicenter, retrospective study
Authors: Xie Yizhao , Ge Rui , Sang Die , Luo Ting , Li Wei , Ji Xuening , Yuan Peng , Wang Biyun 
Published: February 2020

AbstractLapatinib is widely used in the later lines treatment of HER2 positive metastatic breast cancer (MBC). EGF104900 study suggested that among patients who experienced progression on prior trastuzumab‐containing regimens, lapatinib plus trastuzumab had better effects than trastuzumab alone. However, no evidence was discovered in terms of lapatinib plus capetabine compared with lapatinib plus trastuzumab plus chemotherapy, as well as a treatment after progression on lapatinib. We evaluated the medical records retrospectively of all MBC patients with HER2 positive disease who progressed on prior trastuzumab‐containing regimens (advanced setting) and a taxane (any setting) and received lapatinib‐based treatment from 2015 to 2018 in five institutions in China. A total of 242 patients were available for analysis. Among them, 164 (68%) patients received lapatinib plus capetabine (LX) and 78 (32%) patients received lapatinib plus trastuzumab and one chemotherapy (HLC). The median progression‐free survival (PFS) of the HLC group was significantly superior to the LX group (8.8 months vs 5.0 months, P < .0000001). No significant difference in grade 3 or worse adverse events was observed in two groups (P = .57). A total of 175 patients were available for the analysis of the postlapatinib treatment. Continuation of lapatinib showed superior mPFS results compared to the non‐anti‐HER2 treatment (4 months vs 2 months, P = .01) and similar results compared to switch to other anti‐HER2 treatments (4 months vs 4 months, P = .88). In patients who had progressed on prior trastuzumab‐base therapy, HLC provided a new dual‐targeting treatment option for the later lines therapy of patients with HER2 positive MBC. Moreover, evidence of cross‐line use of lapatinib was provided.
Management of a Large Artery During Maxillary Sinus Bone Grafting: A Case Report
Authors: Basma Hussein S. , Abou‐Arraj Ramzi V. 
Published: February 2020

IntroductionBranches of the posterior superior artery (PSA) are often found within the lateral wall of the maxillary sinus. Most vessels are small and laceration of the blood vessel during sinus augmentation is not uncommon. Such lacerations can result in intra‐surgical bleeding complicating the augmentation procedure, otherwise they are typically non‐life threatening. The purpose of the present case report is to document a maxillary sinus floor augmentation procedure involving displacement of large artery from its bony canal using a piezoelectric device.Case PresentationA maxillary sinus floor augmentation procedure was performed in a 58‐year‐old healthy female planned for a future implant supported fixed prosthesis. The preoperative computed tomography scan revealed a bony canal within the lateral maxillary sinus wall of the alveolar ridge. The artery tracing obvious on the lateral wall was elevated along with the Schneiderian membrane without any complication or hemorrhage using a piezoelectric device system. The postoperative healing was uneventful.ConclusionElevation of a large diameter PSA branch with the Schneiderian membrane significantly minimizes the risk of vessel laceration and hemorrhagic complications.
Electrochemically Mediated Aqueous Atom Transfer Radical Polymerization of N,N‐Dimethylacrylamide
Authors: De Bon Francesco , Marenzi Sofia , Isse Abdirisak A. , Durante Christian , Gennaro Armando 
Published: February 2020

AbstractElectrochemically mediated atom transfer radical polymerization (ATRP) of N,N‐dimethylacrylamide (DMAA) catalyzed by copper complexes with polydentate amine ligands was studied systematically in water, investigating several reaction parameters such as applied potential, catalyst concentration, ligand structure, monomer and initiator concentrations. Electropolymerizations were successfully performed under both potentiostatic and galvanostatic conditions; in both eATRP modes, reactions were fast (monomer conversion >90 % in less than 1 h) and well‐controlled, providing polymers with narrow molecular weight distributions. Despite the low dispersity, chain extension attempts of the obtained polymer were not successful because of partial loss of C−Br chain‐end functionality, due to an intramolecular nucleophilic attack. This is an intrinsic drawback of ATRP of acrylamides and although the electrochemical approach allowed preparation of well‐defined polymers in a very short time (down to ca. 15 min), loss of chain‐end functionality was unavoidable.
Synthesis of thiazol‐2‐imines from the reduction of single enantiomer 2‐imino‐thiazolidin‐4‐ones followed by a spontaneous water elimination
Authors: Tuncel Senel Teke , Dogan Ilknur 
Published: February 2020

AbstractChiral hemiaminals (5‐8RR and 5‐8SS) have been synthesized from the corresponding 2‐iminothiazolidine‐4‐ones (1‐4RR and 1‐4SS) by LiAlH4 reductions stereoselectively and were then converted to single enantiomer thiazol‐2‐imines (9‐12RR and 9‐12SS) by a water elimination reaction. The kinetics of the dehydration reactions which occurred spontaneously both in the solid state and in the solution have been followed by time dependent 1H nuclear magnetic resonance spectroscopy. The corresponding first order rate constants and free energies of activation values for the conversions have been reported.
Production of vitamin B1 microparticles by a spray drying process using different biopolymers as wall materials
Authors: Carlan Ioana C. , Estevinho Berta N. , Rocha Fernando 
Published: February 2020

AbstractThe aim of this work was to microencapsulate vitamin B1 by spray‐drying using different encapsulating agents (arabic gum, carrageenan, chitosan, maltodextrin, modified chitosan, modified starch, pectin, sodium alginate, and xanthan) and to characterize the microcapsules and study their release. Microcapsules with a 0.25% (w/w) content of vitamin B1 were produced. The product yield results ranged from 17%‐52% and the encapsulation efficiency from 66%‐100%. Three categories of morphology, regular spherical shape, irregular spherical shape with rough surface, and irregular shape, were identified. Their sizes, determined by laser granulometry, ranged from 0.11‐1.32 μm, in terms of number distribution, and from 3.76‐34.43 μm, in volume distribution. Controlled release studies were performed by spectrophotometric analysis, in deionized water (20°C) and simulated gastric fluid (37°C). Different release behaviours were observed from just 10 seconds (modified starch) up to more than 24 hours (xanthan). Kinetic models such as zero‐order, first‐order, Higuchi, Korsmeyer‐Peppas, and Weibull were applied. The Weibull model showed the best fitting with the experimental data. All release tests were repeated after 4 months and showed good stability over time. A mass loss of vitamin B1 lower than 20% was detected. This study demonstrates the possibility of encapsulating vitamin B1 using different encapsulating agents by a spray‐drying technique. Depending on the intended applications, for fast release, adequate results were obtained for maltodextrin, arabic gum, modified chitosan, and sodium alginate, and for slow release, adequate results were only obtained for chitosan and pectin.
Reasoning with words: A hedge algebra linguistic cognitive map approach
Authors: Van Han Nguyen , Cong Vinh Phan 
Published: February 2020

SummaryIn this article, we introduce a method for reasoning with words based on hedge algebra using linguistic cognitive map. Our model consists of set of vertices and edges with value to be linguistic variables which are constrained by linguistic lattice. We figure out relationship between numeric and linguistic domain for fuzzifying data. We also prove convergence theorem on learning method for linguistic cognitive
map.