bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost of dengue in Colombia: A systematic review
Authors: Rodríguez-Morales Alfonso J. , López-Medina Eduardo , Arboleda Iván , Cardona-Ospina Jaime A. , Castellanos Jaime , Faccini-Martínez Álvaro A. , Gallagher Elaine , Hanley Riona , López Pio , Mattar Salim , Pérez Carlos Eduardo , Kastner Randee , Reynales Humberto , Rosso Fernando , Shen Jing , Villamil-Gómez Wilmer E. , Fuquen Marcela 
Published: December 2024

Background
Dengue is hyperendemic in Colombia. It imposes a substantial economic burden on patients, caregivers, society, and the national health system. We intend to identify and synthesize the evidence regarding the economic burden of dengue in Colombia.

Methods
A systematic review (PROSPERO CRD42021257985) of economic studies was performed. A comprehensive search was completed in PubMed, EMBASE, the Cochrane Library, the LILACS, and SciELO databases. Study selection and data extraction was made by two researchers.

Results
160 records were identified. Of these, 14 studies were selected for data extraction. Direct medical cost of dengue is mainly represented by hospitalization (USD 823 to 1,754). The annual aggregated cost is near to USD 159.6 million, with ambulatory care (USD 90.1 million) and fatal cases (USD 30.7 million) representing 75% of the total cost. The aggregate indirect cost (due to loss in income while sick or as a caretaker) was USD 92.8 million. Vaccination seems to reduce the economic cost of dengue.

Conclusions
Dengue financial burden could be challenging for low-income communities as those affected in Colombia. An integrated approach including vector control and the introduction of a vaccine for dengue has the potential to reduce the economic burden of the disease.
Proteomics analysis of body fluid exosomes of rheumatoid arthritis patients underwent oxhorn cupping therapy
Authors: Leng Du , Chimedtseren Chimedragchaa , Wang Tegexibaiyin , Su Ruga , Bao Saren , Mo Xiele , Ge Xigesaiyin , Cha Suna , Xi Runtulaguer , Wu Saqila , Sa RenGaoWa , Zhao Jiaqi , Na Ren , Molor-Erdene Perenlei 
Published: December 2024

Objective
The present study was undertaken to understand the multitarget mechanisms of oxhorn cupping therapy (OHCT) in treating rheumatoid arthritis by proteomic analysis.

Methods
Thirty rheumatoid arthritis patients underwent OHCT and liquid (body fluid) accumulated in the cupping vessels was collected. Exosomes from the body fluid were isolated and characterized by transmission electron microscope (TEM). Particle size analysis, fluorescent labeling, and flow cytometry detection were also performed. Label-free quantitative proteomics analysis was used to detect differentially expressed proteins (DEPs). The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, gene ontology (GO) enrichment, clusters of orthologous groups (COG), and protein-protein interaction (PPI) network were used to perform bioinformatics analysis of DEPs. Enzyme-linked immunosorbent assay (ELISA) was used to detect the key targets regulated by OHCT.

Results
According to TEM images, the average size of exosomes in body fluid of RA patients underwent OHCT was 76.13 nm (5.27E+10 /mL). The positive rates of CD9, CD63, and CD8 were detected on the surface of body fluid exosomes. A total of 300 DEPs (58 up-regulated and 242 down-regulated) were identified between the pre-treatment and post-treatment stages. DEPs were related mostly to protein binding, focal adhesion, extracellular region, post-translational modification and signal transduction. KEGG pathway analysis showed a significant enrichment of DEPs in PI3K-Akt pathway and focal adhesion. Ten DEGs (ITGA5, ITGA4, ENG, MMP14, SERPINH1, THY1, TAGLN, ITGA1, IGF1, and ITGB5) were considered target genes according to PPI network analysis. ELISA showed a slight decrease in the serum levels of CDK1, ITGA5, ITGB5, and CD44 during and after treatment.

Conclusions
Body fluid samples from RA patients treated with oxhorn cupping contain exosomes. OHCT might exert therapeutic effects in RA through multiple signaling pathways and multiple protein targets.
Efficacy and safety of intradialytic parenteral nutrition using ENEFLUID® in malnourished patients receiving maintenance hemodialysis: An exploratory, multicenter, randomized, open-label study
Authors: Kabasawa Hideyuki , Hosojima Michihiro , Kanda Eiichiro , Nagai Miho , Murayama Toshiko , Tani Miyuki , Kamoshita Satoru , Kuroda Akiyoshi , Kanno Yoshihiko 
Published: December 2024

The objective of this study was to investigate the efficacy and safety of intradialytic parenteral nutrition (IDPN) using ENEFLUID® (310 kcal, 550 mL) in mild-moderate malnutrition patients receiving maintenance hemodialysis. A total of 40 adult patients with a Nutritional Risk Index-Japanese Hemodialysis (NRI-JH) score of 5–10 were enrolled in this multicenter, randomized, open-label study. Patients in the intervention group received IDPN using ENEFLUID® via the dialysis circuit 3 times a week for 12 weeks; those in the control group did not. The primary endpoint was change in serum transthyretin (TTR). The secondary endpoints were changes in nutritional laboratory tests, nutritional parameters, food intake, plasma amino acids, and blood glucose. For both groups, mean age (72.1±11.4 years) and BMI (20.3±3.0), and median NRI-JH score [7.0 (interquartile range, 6–8)], did not differ. One patient withdrew before intervention, leaving 20 intervention and 19 control patients. Mean (95% confidence interval) change in serum TTR (mg/dL) at 12 weeks did not differ between groups: Intervention, 1.0 (-1.1–3.2); Control, -0.3 (-2.4–1.9); Intragroup difference, 1.3 (-1.7–4.3); P = 0.41. The values reflecting protein intake at 12 weeks compared to those on the study initiation day increased in the intervention group [the changes of blood urea nitrogen, 9.4 (2.6–16.2) mg/dL; P = 0.007, and normalized protein catabolic rate, 0.10 (0.02–0.18) g/kg/day; P = 0.02]. Mean food protein intake (g/kg/day) at 12 weeks increased in the intervention group and decreased in the control group, and differed between groups: Intervention, 0.12 (-0.03–0.28); Control, -0.18 (-0.43–0.08); Inter-group difference, 0.30 (0.00–0.60); P = 0.050. No adverse events occurred. In patients with mild to moderate malnutrition receiving ENEFLUID® for 12 weeks as IDPN, serum TTR was not improved, decreases in protein intake was mitigated, no adverse events occurred.
Trial registration Name of the registry: Japan Registry of Clinical Trials Registration number: jRCTs031220296.
Systematic evaluation of machine learning models for postoperative surgical site infection prediction
Authors: van Boekel Anna M. , van der Meijden Siri L. , Arbous Sesmu M. , Nelissen Rob G. H. H. , Veldkamp Karin E. , Nieswaag Emma B. , Jochems Kim F. T. , Holtz Jeroen , Veenstra Annekee van IJlzinga , Reijman Jeroen , de Jong Ype , van Goor Harry , Wiewel Maryse A. , Schoones Jan W. , Geerts Bart F. , de Boer Mark G. J. 
Published: December 2024

Background
Surgical site infections (SSIs) lead to increased mortality and morbidity, as well as increased healthcare costs. Multiple models for the prediction of this serious surgical complication have been developed, with an increasing use of machine learning (ML) tools.

Objective
The aim of this systematic review was to assess the performance as well as the methodological quality of validated ML models for the prediction of SSIs.

Methods
A systematic search in PubMed, Embase and the Cochrane library was performed from inception until July 2023. Exclusion criteria were the absence of reported model validation, SSIs as part of a composite adverse outcome, and pediatric populations. ML performance measures were evaluated, and ML performances were compared to regression-based methods for studies that reported both methods. Risk of bias (ROB) of the studies was assessed using the Prediction model Risk of Bias Assessment Tool.

Results
Of the 4,377 studies screened, 24 were included in this review, describing 85 ML models. Most models were only internally validated (81%). The C-statistic was the most used performance measure (reported in 96% of the studies) and only two studies reported calibration metrics. A total of 116 different predictors were described, of which age, steroid use, sex, diabetes, and smoking were most frequently (100% to 75%) incorporated. Thirteen studies compared ML models to regression-based models and showed a similar performance of both modelling methods. For all included studies, the overall ROB was high or unclear.

Conclusions
A multitude of ML models for the prediction of SSIs are available, with large variability in performance. However, most models lacked external validation, performance was reported limitedly, and the risk of bias was high. In studies describing both ML models and regression-based models, one modelling method did not outperform the other.
HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis
Authors: Mendivelso-González Daniel Felipe , Clavijo Cabezas Daniel , Montoya Luisa , Plazas Vargas Merideidy , López-Correa Patricia , Colón Eugenia , Parra-Medina Rafael 
Published: December 2024

Purpose
HER2-low has garnered significant attention for the treatment of HER2-negative breast cancer. We aimed to determine the prevalence of HER2-low expression in Hispanic/Latino women with breast cancer (BC).

Methods
We searched in Embase, LILACS, and Medline databases for articles reporting the expression of HER2 immunohistochemistry with scores reported as 0, 1+, 2+, or 3+, with equivocal cases (2+) confirmed through in situ hybridization (ISH).

Results
A total of 12 articles were finally included, comprising 73,467 individuals. The prevalence of HER2-zero, HER2-low and HER2 positive cases among all BC (0, 1+, 2+/ISH-, 2+/ISH+ and 3+), was 45.0%, 32.0%, and 23.0%, respectively. The prevalence of HER2-zero and HER2-low expression among negative cases (0, 1+ and 2+/ISH-), was 53.0% and 47.0%, respectively.

Conclusion
There is an important percentage of Hispanic/Latino individuals who would benefit from HER2-targeted therapies, even in HER2 negative cases. Additional research on the prevalence of HER2-low tumors across a wider range of Latin American countries is required to better understand the molecular epidemiology of this biomarker within the Hispanic/Latino population.
Low thoracic skeletal mass index, a novel marker to predict recurrence of aspiration pneumonia in the elderly stroke patients
Authors: Gil Bo Mi , Im Sun , Hong Yu Jin , Kang Hye Seon 
Published: December 2024

Purpose
We investigated whether thoracic skeletal muscle mass index at the diagnosis of aspiration pneumonia (AP) is a predictor for AP recurrence and explored predicting factors for AP recurrence in patients with stroke.

Patients and methods
This study retrospectively reviewed data of patients with AP who were diagnosed with stroke and who had full medical follow-up data from January 2014 to July 2020 in the Catholic University of Korea Bucheon St. Mary’s Hospital. AP was defined based on clinical signs and/or symptoms suggestive of pneumonia and radiologic findings of pneumonic infiltrations in the dependent portions of the lung. We measured thoracic muscle volume using the cross-sectional area (CSA) of the erector spinae muscle (ESMCSA, cm2) at the 12th vertebral region. Computed tomography scans at the time of AP diagnosis during the acute stroke period were used for analysis and respective CSAs were divided by height squared (m2) to yield the muscle index at T12 (T12MI, cm2/m2) to normalize for stature. Multivariate logistic regression models were used to investigate relationships between clinical parameters and AP recurrence.

Results
During the study period, a total of 268 stroke patients with dysphagia who developed AP were analyzed. The mean T12MI of patients with and without recurrence of AP was 622.3±184.1 cm2/m2 and 708.1±229.9 cm2/m2, respectively (P = 0.001). Multivariate logistic regression revealed that lower T12MI (P = 0.038) and older age (P = 0.007) were independent predictors of AP recurrence in patients with stroke and dysphagia.

Conclusion
Low thoracic muscle index at the diagnosis of initial AP after stroke can predict subsequence AP recurrence.
Assessment of changes in intra-abdominal pressure and cardiac output induced by liver compression in healthy anesthetized spontaneously breathing dogs
Authors: Seo Daeyun , Lim Seongsoo , Namgoong Beomkwan , Uhm Heesung , Hong Hyeajeong , Lee Nanju , Kim Isong , Heo Seunghun , Kang Ji Hwan , Kim Cheyoun , Shin Hayoung , Her Jiwoong , Kim Min Su 
Published: December 2024

Objective
Liver compression (LC) has been proposed to predict fluid responsiveness in human pediatric patients. Because the evaluation of fluid responsiveness through LC depends on the mechanism of increased intra-abdominal pressure (IAP), understanding the impact of LC on IAP, cardiac output (CO), and respiratory parameters is essential. Thus, this study aimed to investigate the effects of LC on these parameters.

Methods
The present study used six healthy beagles. All dogs were anesthetized with isoflurane and allowed to breathe spontaneously in dorsal recumbency. After instrumentation, LC was performed at four different pressures in a sequential, non-randomized manner: (1) 10 mmHg, approximately half of the minimum value within the range; (2) 22 mmHg, a commonly used pressure within the range; (3) 44 mmHg, twice the pressure of the minimum value within the range; and (4) 60 mmHg, twice the pressure of the maximum value within the range. At each pressure, CO via transthoracic echocardiography, IAP, and cardiorespiratory parameters were measured before, during, and after LC.

Results
Overall, our results showed that the IAP was significantly increased at all pressures during LC (P < 0.001), yielding a linear correlation between LC pressure and IAP (P < 0.001; r² = 0.89). The maximum IAP during LC was 7 mmHg, and intra-abdominal hypertension was not induced. LC at 22 mmHg significantly increased the IAP by 1.7 mmHg, but did not significantly alter the CO or respiratory parameters.

Conclusions
This is the first study to evaluate the effects of LC on IAP, CO, and respiratory parameters in healthy, anesthetized, and spontaneously breathing dogs. Our findings indicate that applying LC with a commonly used pressure may have a low risk of inducing intra-abdominal hypertension and related complications. Further studies are required to explore the use of LC in various clinical settings.
Validation by experimental study the relationship between fabric tensile strength and weave structures
Authors: Messnaoui Redouane , El Bakkali Mhammed , Elkhaoudi Mostafa , Soulhi Aziz , Cherkaoui Omar 
Published: December 2024

Abstract
Fabric strength plays a crucial role in determining and influencing all other performance attributes of textiles. Therefore, considering the strength of the fabric becomes essential when choosing the appropriate textile for a specific purpose. This article presents an experimental study that focusses on the properties of 100% polyester fabrics. To conduct this study, we created ten fabrics with different weave structures, resulting in a total of 200 samples for tensile strength testing. Moving on to the second phase, we analysed the physical and constructional characteristics of the fabrics, including the number of warp and weft threads, warp and weft density, and weight. This analysis was carried out based on the weave structures. Additionally, we performed tensile strength tests in both warp and weft directions to examine the mechanical properties of the fabrics. Finally, a statistical analysis was performed to determine the impact of the weave structures on the tensile strength of the fabrics.
Influence of sewing parameters on the skin–fabric friction
Authors: Sun Guangwu , Li Guanzhi , Dong Dongdong , Hu Hongyan , Li Chulin 
Published: December 2024

Abstract
The mechanical properties of seaming stitch have been frequently reported. However, the frictional characteristics of seaming stitch have long been ignored. In this article, to reveal the influence of sewing process on the fabric’s friction, we measured the coefficient of friction (COF) of fabric with different seam patterns. These seam patterns were fabricated by using controllable sewing thread and sewing process. On the basis of our experiment, we found that the COF of fabric’s front was higher than that of fabric’s back. Another conclusion is that the COF in the weft direction was higher than that in the warp direction. Additionally, thin sewing thread, long stitch, and large seam space can cause low COF. On the contrary, relative high COF is generated by thick sewing thread, short stitch, and small seam space. According to our results, we expect to provide the matching suggestion between the fabric and seam pattern from the point view of trichology.
“Export” of ninth- to tenth-century Chinese bronze mirrors: Shipwreck findings from the Java Sea
Authors: Chen Canping 
Published: December 2024

Abstract
This study examines the “export” of Chinese bronze mirrors and their destinations from the ninth to the tenth century, focusing on three shipwrecks—Belitung, Intan, and Cirebon—discovered in the Java Sea, Indonesia. Approximately 70 Chinese bronze mirrors were recovered from these wrecks. Through a comprehensive analysis of the styles, assemblages, and spatial distribution of the mirrors found on these shipwrecks, and by comparing them with contemporaneous examples unearthed from tombs, pagodas, and hoards, this study argues that the distinction between “export” bronze mirrors and those “domestic” lies in the coexistence of new and old mirrors in the export cases. These export assemblages featured a higher proportion of heavier and more exquisitely crafted “old mirrors.” This distinction is attributed to the specific demands of overseas markets such as Southeast Asia, West Asia, and Central Asia for high-quality Chinese bronze products.
When English isn’t enough in advertising: the role of language, ad length, and complexity in consumer attitudes across Spain and Poland
Authors: Rojo López Ana María , Nowak Katarzyna Anna 
Published: December 2024

Abstract
The use of English in advertising across non-English-speaking countries is pervasive, often seen as a strategy to evoke prestige, modernity, and global appeal. However, its effectiveness may depend on factors such as text length, linguistic complexity, and local language use, which remain underexplored. This study investigates how Spanish and Polish consumers respond to English-language advertisements of varying lengths (for a cream, a watch, and a perfume) featured in women’s glossy magazines, examining whether English is as effective as often assumed or if its impact is moderated by these factors. The study involved 210 university students: 105 from the Catholic University of Murcia (Spain) and 105 from Maria Curie-Skłodowska University (Poland). Findings reveal that while both Spanish and Polish participants generally favored advertisements primarily or partially in English (i.e., code-mixed) over those solely in their native languages, this preference did not consistently enhance their evaluations of the advertised products. Products were rated more favorably when presented in the native language, especially in longer, more linguistically complex ads. By contrast, shorter ads elicited more positive attitudes towards the product when English was used. These findings suggest that the symbolic appeal of English interacts with linguistic complexity and cultural factors, indicating that English is not universally effective in advertising. While English remains attractive to consumers, its use should be balanced with considerations of clarity, comprehension, and the cultural resonance of the local language to avoid undermining advertising effectiveness. Results highlight the nuanced role of English in advertising, challenging assumptions about its universal appeal and providing insights into designing multilingual campaigns that resonate with diverse audiences across Europe.
Association Between SARC-F and Clinical Outcomes in Older Adults With Cardiovascular Diseases Admitted to the Emergency Room: A Longitudinal Study
Authors: Sousa Luciana D. L. , de Lima Paloma B. , Dos Santos Mariana D. G. , de Macedo Osmair G. , Alexandre Tiago D. S. , Garcia Patrícia A. 
Published: December 2024

Introduction:
Sarcopenia can be more significant and severe in the presence of cardiovascular diseases. In hospitalized older adults with acute cardiac disease, assessing strength parameters, muscle mass, and physical performance is difficult largely because of bed rest restrictions. In this context, simple questionnaire to rapidly diagnose sarcopenia (SARC-F) emerges as a feasible screening tool to identify sarcopenia in an emergency room setting.

Objectives:
Assess the association between SARC-F, length of stay, mechanical ventilation, and in-hospital mortality in older adults with cardiovascular diseases admitted to the ER.

Methodology:
An observational longitudinal study with 160 Brazilian older adults with cardiovascular diseases admitted to the hospital following an ER visit. The risk of sarcopenia was assessed by the SARC-F tool (independent variable). Length of stay, use of mechanical ventilation, and in-hospital mortality were the dependent variables, collected via an electronic medical chart. Data were analyzed by simple and multiple linear and logistic regression.

Results:
SARC-F explained 62% of length of stay, adjusted for the confounding variables age, male sex, and use of continuous medication, mechanical ventilation, and corticosteroids. Risk of sarcopenia was also associated with mechanical ventilation during hospitalization (odds ratio = 1.398; 95% CI, 1.018-1.919). SARC-F was not related to mortality.

Conclusion:
Older adults with cardiovascular diseases hospitalized at greater risk of sarcopenia were more likely to need invasive mechanical ventilation and more prone to prolonged hospital stays.