bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interface Heteroatom‐doping: Emerging Solutions to Silicon‐based Anodes
Authors: Zhang Fangzhou , Luo Wei , Yang Jianping 
Published: March 2020

AbstractSilicon‐based composites have been recognized as a promising anode material for high‐energy lithium‐ion batteries (LIBs). However, the intrinsically low conductivity and the huge volume expansion during lithiation/delithiation progresses impede its further practical applications. In the past decades, numerous efforts have been made for surface and interface modification of Si‐based anodes. Among these, doping of active materials with heteroatoms is one promising method to endow silicon many unmatched electrochemical properties. In this review, we focus on the effects of heteroatom doping on the interfacial properties of Si‐based anodes, and some typical strategies for the interface doping are highlighted. We aim to give some reference for interfacial doping of Si‐based anodes in LIBs.
Functional complaints and quality of life after transanal total mesorectal excision: a meta-analysis
Authors: Heijden J A G , Koëter T , Smits L J H , Sietses C , Tuynman J B , Maaskant-Braat A J G , Klarenbeek B R , Wilt J H W 
Published: March 2020

AbstractBackgroundTotal mesorectal excision (TME) gives excellent oncological results in rectal cancer treatment, but patients may experience functional problems. A novel approach to performing TME is by single-port transanal minimally invasive surgery. This systematic review evaluated the functional outcomes and quality of life after transanal and laparoscopic TME.MethodsA comprehensive search in PubMed, the Cochrane Library, Embase and the trial registers was conducted in May 2019. PRISMA guidelines were used. Data for meta-analysis were pooled using a random-effects model.ResultsA total of 11 660 studies were identified, from which 14 studies and six conference abstracts involving 846 patients (599 transanal TME, 247 laparoscopic TME) were included. A substantial number of patients experienced functional problems consistent with low anterior resection syndrome (LARS). Meta-analysis found no significant difference in major LARS between the two approaches (risk ratio 1·13, 95 per cent c.i. 0·94 to 1·35; P = 0·18). However, major heterogeneity was present in the studies together with poor reporting of functional baseline assessment.ConclusionNo differences in function were observed between transanal and laparoscopic TME.
Sex differences in hypothalamic–pituitary–adrenal axis regulation after chronic unpredictable stress
Authors: Palumbo Michelle C. , Dominguez Sky , Dong Hongxin 
Published: March 2020

AbstractIntroductionExposure to stress, mediated through the hypothalamic–pituitary–adrenal (HPA) axis, elicits sex differences in endocrine, neurological, and behavioral responses. However, the sex‐specific factors that confer resilience or vulnerability to stress and stress‐associated psychiatric disorders remain largely unknown. The evident sex differences in stress‐related disease prevalence suggest the underlying differences in the neurobiological underpinnings of HPA axis regulation.MethodHere, we used a chronic unpredictable stress (CUS) model to investigate the behavioral and biochemical responses of the HPA axis in C57BL/6 mice. Animals were tested in the open field and forced swim test to examine anxiety‐like and depressive‐like behaviors. Plasma corticosterone levels were measured after behavior and CUS, and glucocorticoid receptor (GR) expression and cytosolic and nuclear fractions of binding protein FKBP51 expression were taken to measure function and regulation of the stress response.ResultsOur results indicate increased depressive‐like behavior in males and females which correlated with increased corticosterone levels following CUS. However, females displayed more anxiety‐like behaviors with and without CUS. Interestingly, we found trends toward dysregulation of GR protein expression in CUS females, and an increase in the GR inhibitory protein, FKBP51, in the cytosol of CUS males but not females.ConclusionThese results suggest biochemical alterations to the HPA axis regulation which may elicit a glucocorticoid resistance in females after chronic stress and may contribute to the sex‐biased vulnerability to stress‐related psychiatric disorders.
Next‐generation sequencing for BCR‐ABL1 kinase domain mutations in adult patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia: A position paper
Authors: Soverini Simona , Albano Francesco , Bassan Renato , Fabbiano Francesco , Ferrara Felicetto , Foà Robin , Olivieri Attilio , Rambaldi Alessandro , Rossi Giuseppe , Sica Simona , Specchia Giorgina , Venditti Adriano , Barosi Giovanni , Pane Fabrizio 
Published: March 2020

AbstractEmergence of clones carrying point mutations in the BCR‐ABL1 kinase domain (KD) is a common mechanism of resistance to tyrosine kinase inhibitor (TKI)‐based therapies in Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL). Sanger sequencing (SS) is the most frequently used method for diagnostic BCR‐ABL1 KD mutation screening, but it has some limitations—it is poorly sensitive and cannot robustly identify compound mutations. Next‐generation sequencing (NGS) may overcome these problems. NSG is increasingly available and has the potential to become the method of choice for diagnostic BCR‐ABL1 KD mutation screening. A group discussion within an ad hoc constituted Panel of Experts has produced a series of consensus‐based statements on the potential value of NGS testing before and during first‐line TKI‐based treatment, in relapsed/refractory cases, before and after allo‐stem cell transplantation, and on how NGS results may impact on therapeutic decisions. A set of minimal technical and methodological requirements for the analysis and the reporting of results has also been defined. The proposals herein reported may be used to guide the practical use of NGS for BCR‐ABL1 KD mutation testing in Ph+ ALL.
Exploring garment rental as a sustainable business model in the fashion industry: Does contamination impact the consumption experience?
Authors: Clube Rebecca K. M. , Tennant Mike 
Published: March 2020

AbstractFashion has evolved into an unsustainable industry; fast fashion, which has a low‐cost, high‐volume focus is the dominant business strategy, resulting in vast resource use and environmental externalities. The purpose of this research is to support the transition to a more circular industry through exploring the opportunity for short‐term garment rental as a part of a product‐service shift. A number of consumer barriers exist to the adoption of novel business models. Included is the issue of contamination; literature suggests that an item may be considered contaminated when another person or object interacts with it. This poses a fundamental conflict to the garment rental proposition. This study furthers understanding of contamination through a qualitative content analysis of 566 online reviews of two existing fashion rental providers. This enables insight into the actual customer experience, revealing a range of contamination incidences—most commonly visual and odour‐related. The impact of a contamination event on the customer experience was overwhelmingly recorded as negative, at worst resulting in total rejection of the entire rental concept. The analysis suggests that contamination presents a psychological and practical obstacle to successful rental. A range of managerial implications were raised with corresponding recommendations offered to mitigate and reduce contamination across the value chain. The study highlights that trade‐offs exist between product quality and commercial profitability. Findings suggest that rental is likely to be a challenging business model, raising the need for further academic and practitioner research to augment the findings.
Isolation, Characterization, and Possible Anti‐Alzheimer's Disease Activities of Bisabolane‐Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa
Authors: Wu Pei‐Qian , Li Bing , Yu Yi‐Fan , Su Pan‐Jie , Liu Xu , Zhang Zong‐Ping , Zhi De‐Juan , Qi Feng‐Ming , Fei Dong‐Qing , Zhang Zhan‐Xin 
Published: March 2020

AbstractOne new bisabolane‐type sesquiterpenoid, together with four known bisabolane‐type sesquiterpenoid derivatives and seven phenolics, was isolated from the rhizomes of Curcuma longa. Their structures were elucidated by extensive spectroscopic (IR, HR‐ESI‐MS, and NMR) data analysis. The possible anti‐Alzheimer's disease (AD) activities of the isolated compounds were also evaluated using Caenorhabditis elegans AD pathological model, and 1β‐hydroxybisabola‐2,10‐dien‐4‐one had the highest possible anti‐AD activity.
Changes in phenolic content, antioxidant activity, and volatile compounds during processing of fermented sorghum grain tea
Authors: Sun Hongyi , Wang Haoxin , Zhang Pangzhen , Ajlouni Said , Fang Zhongxiang 
Published: March 2020

AbstractBackground and objectiveSorghum is an important cereal crop with abundant content of polyphenols and may be used to develop nutraceutical sorghum grain tea. This study investigated the changes of phenolic content, antioxidant capacity, and volatile compounds in sorghum grain during the production of fermented sorghum grain tea using Lactobacillus plantarum subsp. Argentoratensis (LAB) and Saccharomyces cerevisiae.FindingsSignificant (p < .05) changes in total phenolic content (TPC), total flavonoid content (TFC), and condensed tannin content (CTC) were observed during the soaking, fermentation, steaming, and roasting process. TPC, TFC, and CTC were significantly decreased after soaking, steaming, and fermentation stages, whereas roasting led to a significant increase. A total of 53 volatile compounds were recorded from raw and processed sorghum. Pyrazines, phenols, and esters were the most abundant volatile compounds. Alcohols, carboxylic acids, ketones, and alkanes decreased during processing. Esters increased during soaking, steaming, and fermentation but decreased during roasting.ConclusionsProcessing affected the phenolic content significantly (p < .05) and changed the volatile profiles of sorghum grain. Fermented sorghum grain tea by Saccharomyces cerevisiae showed a higher possibility of being developed as sorghum grain tea.Significance and noveltyThe study developed a practical method to process novel sorghum grain tea products.
Severe esophageal stenosis in a patient with metastatic colon cancer following palliative radiotherapy, ramucirumab, and chemotherapy
Authors: Akahane Keiko , Shirai Katsuyuki , Wakatsuki Masaru , Ogawa Kazunari , Minato Kyosuke , Hamamoto Kohei , Takahashi Satoru , Suzuki Koichi , Takahashi Jun , Rikiyama Toshiki , Matsumoto Keita , Mashima Hirosato 
Published: March 2020

AbstractAntiangiogenic agents, such as ramucirumab, should be cautiously administered along with radiotherapy because of the enhanced risk of adverse events.
Acquired von Willebrand syndrome and lymphoproliferative disorders: A case report
Authors: Nicol Christophe , Raj Leela , Guillerm Gaëlle , Couturaud Francis , Eveillard Jean‐Richard , Pan‐Petesch Brigitte 
Published: March 2020

AbstractAcquired von Willebrand syndrome is a rare bleeding disorder often secondary to an underlying lymphoproliferative disorder. We report a case in whom response of both the acquired von Willebrand syndrome and smoldering multiple myeloma persist 14 months after daratumumab treatment discontinuation.
A mandibular second molar with a middle mesial root canal
Authors: Nagahara Takayoshi , Takeda Katsuhiro , Wada Keinoshin , Shirawachi Satomi , Iwata Tomoyuki , Kurihara Hidemi , Shiba Hideki 
Published: March 2020

AbstractThe present case report describes the clinical detection and root canal management of a rare middle mesial canal of a Japanese mandibular second molar by troughing preparation using an operating microscope and cone‐beam computed tomography.
The use of His bundle pacing for the treatment of painful left bundle branch block syndrome
Authors: Smith Kevin Andrew , Frey Julie , McKenzie Amber , Hornsby Kyle , Strobel John 
Published: March 2020

AbstractPainful left bundle branch block syndrome is a rare disorder in which patients develop typical angina‐like pain without identifiable ischemia. To date, there have been few published cases of effective treatment. In this case report, we describe successful implementation of His bundle pacing for durable symptom resolution in this disorder.
Insights into Electroreductive Dehalogenation Mechanisms of Chlorinated Environmental Pollutants
Authors: Yin Hanshuang , Cao Xingkai , Lei Chao , Chen Wenqian , Huang Binbin 
Published: March 2020

AbstractThe electroreductive cleavage of carbon‐chloro bonds has attracted increasing attention from both environmental and mechanistic points of view over the past decades, taking into consideration a large variety of chlorinated organic compounds. Important discoveries have been made on the underlying electron/hydrogen transfer mechanisms and the enhancement of dechlorination performance for electrocatalysis purposes over the last years. However, there is still missing a combined knowledge from individual researches to specially elucidate the electroreductive dehalogenation mechanisms of organic chlorides. Herein, we summarize the diverse electrochemical strategies applied to reductive dehalogenation of chlorinated environmental pollutants, including direct electrochemical reduction, electrocatalytic hydro‐dechlorination and electrochemically mediated reduction methods, and, especially, highlight the differences in reductive dehalogenation mechanisms. Specifically, direct electron transfer is the most common dechlorination mechanism involved in the direct electrochemical reduction of organic chlorides, in which the electron transfer to C−Cl bonds can be classified as concerted or stepwise dissociative electron transfer mechanism. Indirect atomic hydrogen reduction is the primary dechlorination mechanism in the electrocatalytic hydro‐dechlorination process, which often competes with the direct electrochemical reduction route. Electrochemically mediated reduction, as another indirect route, uses a redox‐active mediator to indirectly transfer electrons from cathode to organic chlorides, resulting in reductive dehalogenation reaction. Moreover, the effects of critical factors on the dehalogenation reactivity and mechanisms are also discussed to better demonstrate the electroreductive dehalogenation of organic chlorides. Lastly, this contribution highlights recent relevant advances in electroreductive dehalogenation issues, as well as the challenges and potentials of this process.
A numerical study on critical ventilation velocity in slope tunnel fire under vehicle blockage
Authors: Liang Huagang , Pang Liqin , Gao Dongmei 
Published: March 2020

AbstractThe particularity of highway tunnel location and the limitation of space result in the closure of its environment, which makes evacuation, rescue, and firefighting activities more difficult. In this study, a fire dynamics simulator was used for numerical simulation to study the effect of jamming on the critical velocity of slope tunnel fire. This experiment carried out two sets of working conditions simulations: (1) In the straight tunnel, the heat release rate and the blockage ratio are considered and numerically simulated. (2) Under the heat release rate of 20 MW fire source, the blockage ratio and the gradient of the tunnel are considered and numerically simulated. The vehicle blockage is set to distribute in two rows and two columns upstream of the fire source, accounting for 6.6%‐22.0% of the cross‐section of the tunnel. The slopes were selected in nine cases of 0%, ±1%, ±2%, ±3%, and ±4%. The six heat release rates were 5 MW, 10 MW, 15 MW, 20 MW, 25 MW, and 30 MW, respectively. The fire occurred on the tunnel centerline. The results show that in flat tunnels, the variation trend of critical velocity with heat release rate is basically the same, and it increases with the increase of heat release rate. However, when the heat release rate is the same, the larger the vehicle blockage ratio is, the smaller the critical velocity is. It can be seen from the second experimental case that the influence of the tunnel slope on the critical velocity is different. In the downhill tunnel, the critical velocity increases with the increase of slope. In the uphill tunnel, the critical velocity decreases with the increase of slope.
A Versatile Approach to Dynamic Amide Bond Formation with Imine Nucleophiles
Authors: Erguven Huseyin , Keyzer Evan N. , Arndtsen Bruce A. 
Published: March 2020

AbstractDynamic covalent chemistry has rapidly become an important approach to access supramolecular structures. While the products generated in these reactions are held together by covalent bonds, the reversible nature of the transformations can limit the utility of many these systems in creating robust materials. We describe herein a method to form stable and commonly employed amide bonds by exploiting the reversible coupling of imines and acyl chlorides. The reaction employs easily accessible reagents, is dynamic under ambient conditions, without catalysts, and can be trapped with simple hydrolysis. This offers an approach to create broad families of amide products under thermodynamic control, including the selective formation of amide macrocycles or polymers.
Comparative in vitro Studies of the Topoisomerase I Inhibition and Anticancer Activities of Metallated N‐Confused Porphyrins and Metallated Porphyrins
Authors: Halder Nyancy , Dzhemileva Lilya U. , Ramazanov Ilfir R. , D'yakonov Vladimir A. , Dzhemilev Usein M. , Rath Harapriya 
Published: March 2020

AbstractUsing the original approach, a series of metallated N‐confused porphyrins and metallated porphyrins have been synthesized and characterized. For all the synthesized porphyrins, in vitro studies of cytotoxic activity against K562, U937, HL‐60, Jurkat, A549 and HeLa cancer cell lines, the ability to induce apoptosis and effects on the cell cycle as well as the kinetics of proliferative activity of porphyrins and their respective metallated complexes in real time have been developed. The inhibitory activity of metallated porphyrins against human topoisomerase I and the possible mechanism of inhibition have been carried out by modelling using molecular docking.
Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P‐Glycoprotein ABCB5
Authors: Yaremenko Ivan A. , Coghi Paolo , Prommana Parichat , Qiu Congling , Radulov Peter S. , Qu Yuanqing , Belyakova Yulia Yu. , Zanforlin Enrico , Kokorekin Vladimir A. , Wu Yuki Yu Jun , Fleury Fabrice , Uthaipibull Chairat , Wong Vincent Kam Wai , Terent'ev Alexander O. 
Published: March 2020

AbstractThis article discloses a new horizon for the application of peroxides in medical chemistry. Stable cyclic peroxides are demonstrated to have cytotoxic activity against cancer cells; in addition a mechanism of cytotoxic action is proposed. Synthetic bridged 1,2,4,5‐tetraoxanes and ozonides were effective against HepG2 cancer cells and some ozonides selectively targeted liver cancer cells (the selectivity indexes for compounds 11 b and 12 a are 8 and 5, respectively). In some cases, tetraoxanes and ozonides were more selective than paclitaxel, artemisinin, and artesunic acid. Annexin V flow‐cytometry analysis revealed that the active ozonides 22 a and 23 a induced cell death of HepG2 by apoptosis. Further study showed that compounds 22 a and 23 a exhibited a strong inhibitory effect on P‐glycoprotein (P‐gp/ABCB5)‐overexpressing HepG2 cancer cells. ABCB5 is a key player in the multidrug‐resistant phenotype of liver cancer. Peroxides failed to demonstrate a direct correlation between oxidative potential and their biological activity. To our knowledge this is the first time that peroxide diastereoisomers have been found to show stereospecific antimalarial action against the chloroquine‐sensitive 3D7 strain of Plasmodium falciparum. Stereoisomeric ozonide 12 b is 11 times more active than stereoisomeric ozonide 12 a (IC50=5.81 vs 65.18 μm). Current findings mean that ozonides merit further investigation as potential therapeutic agents for drug‐resistant hepatocellular carcinoma.
Association of adverse events and associated cost with efficacy for approved relapsed and/or refractory multiple myeloma regimens: A Bayesian network meta‐analysis of phase 3 randomized controlled trials
Authors: Dhakal Binod , Narra Ravi K. , Giri Smith , Szabo Aniko , Smunt Timothy L. , Ghose Sanjoy , Pathak Lakshmi Kant , Aryal Madan , Hamadani Mehdi , Chhabra Saurabh , Janz Siegfried , D’Souza Anita , Hari Parameswaran N. 
Published: March 2020

BackgroundSeveral new treatment options have been approved for relapsed and/or refractory multiple myeloma (RRMM). In this systematic review, associations of the efficacy of each approved regimen with adverse events (AEs) and the total cost per cycle were compared with a Bayesian network meta‐analysis (NMA) of phase 3 randomized controlled trials (RCTs).MethodsScopus, Cochrane, PubMed Publisher, and Web of Science were searched from January 1999 to July 2018 for phase 3 RCTs of regimens (approved by the US Food and Drug Administration) used in RRMM. The relative ranking of agents was assessed with surface under the cumulative ranking (SUCRA) probabilities. The primary efficacy, safety, and cost outcomes were progression‐free survival with the regimen, grade 3 to 4 AEs, and the total cost per cycle (regimen cost plus average cost of managing AEs).ResultsFifteen studies including 7718 patients and evaluating 14 different regimens were identified. Daratumumab, lenalidomide, and dexamethasone were ranked highest for reducing progression (hazard ratio, 0.13; 95% credible interval, 0.09‐0.19; SUCRA, 1) but carried the highest probability of total cost per cycle ($41,420; 95% Credible Interval [CrCl], $58,665‐$78,041; SUCRA, 0.02). Panobinostat, bortezomib, and dexamethasone were the least effective and least safe (SUCRA, 0.24), whereas bortezomib, thalidomide, and dexamethasone emerged as least effective with the highest total cost per cycle (SUCRA, 0.33). Carfilzomib and dexamethasone emerged as the winner when this regimen was considered in terms of efficacy and safety (SUCRA, 0.61) and efficacy and total cost per cycle (SUCRA, 0.60).ConclusionsThe results of this NMA can provide additional guidance for the decision‐making process when one is choosing the most appropriate regimen for RRMM.
Preparation and Characterization of Silver(I) Ethylcellulose Thin Films as Potential Food Packaging Materials
Authors: Scarpelli Francesca , Crispini Alessandra , Giorno Eugenia , Marchetti Fabio , Pettinari Riccardo , Di Nicola Corrado , De Santo Maria Penelope , Fuoco Erica , Berardi Riccardo , Alfano Pasquale , Caputo Paolino , Policastro Debora , Oliviero Rossi Cesare , Aiello Iolinda 
Published: March 2020

AbstractAg(I)‐containing ethylcellulose (EC) films suitable as antbacterial packaging materials have been prepared and fully characterized. Different preparation methods, including the use of green casting solvents, are proposed. The Ag(I) acylpyrazolonato complexes, [Ag(Qpy,CF3)(L)], L=benzylimidazole (Bzim) and L=ethylimidazole (EtimH), used as active additives, display different modes of interactions with EC, depending on their structural features. A thorough investigation of the EC liquid‐crystalline lyotropic phase and its changes with the introduction of silver additives, has been conducted, revealing either the inclusion of complex molecules into the inner structure of the EC matrix or their dispersion on its surface. Moreover, the bactericidal activity of the prepared Ag(I) films seems to be related to the interaction between silver additives and the polymeric EC matrix. Indeed, the EC‐2b films show a particularly good performance even with a low silver content, with a relative bacterial killing of about 100 %. Tests for Ag(I) migration have been performed by using three food stimulants under two assay conditions. Low values of silver release are recorded, particularly at low concentration of silver content, in the case of all new prepared Ag(I) films.