bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of glass fiber posts on the fracture susceptibility of endodontically treated maxillary anterior teeth with direct veneers: Preliminary results of a randomized clinical trial
Authors: Jurema AnaLuiza Barbosa , Bresciani Eduardo , Caneppele Taciana Marco Ferraz 
Published: October 2020

AbstractObjectiveThe purpose of this randomized clinical trial was to evaluate the influence of glass fiber posts on fracture susceptibility of endodontically treated maxillary anterior teeth with direct veneers.Materials and MethodsFifty participants had 1 maxillary anterior tooth restored with a direct veneer. They were divided into 2 groups (n = 25) according to the use of intraradicular glass fiber posts. Clinical evaluation was performed at baseline, 6 and 12 months. The treatment success was determined by the absence of tooth fracture. If there was fracture, it was classified according to its extent. Fischer exact test was performed to analyze the criteria among the groups at each evaluation time. Friedman repeated analysis of variance assessed the difference in the performance of each group at three recall times (α = 0.5).ResultsFor control group, at the 6‐month follow‐up, one tooth had suffered a catastrophic failure, which resulted in tooth extraction. Fisher statistical analysis showed no significant difference between the cumulative success rate of the groups for the 6 (P > .999) and the 12‐month (P > .999) period. Friedman test showed no significant difference among the periods of evaluation (P > .999).ConclusionsBoth groups had a similar success rate for maxillary anterior endodontically treated teeth with direct veneers after 12 months.Clinical implicationsGlass fiber post use does not influence the fracture susceptibility of maxillary anterior endodontically treated teeth with direct veneers in the short term.
Anatomy of the mechanosensory lateral line canal system and electrosensory ampullae of Lorenzini in two species of sawshark (fam. Pristiophoridae)
Authors: Wueringer Barbara E. , Winther‐Janson Marit , Raoult Vincent , Guttridge Tristan L. 
Published: October 2020

AbstractIt has long been assumed that the elongated rostra (the saws) of sawsharks (family: Pristiophoridae) and sawfish (family: Pristidae) serve a similar function. Recent behavioural and anatomical studies have shed light on the dual function of the pristid rostrum in mechanosensory and electrosensory prey detection and prey manipulation. Here, the authors examine the distributions of the mechanosensory lateral line canals and electrosensory ampullae of Lorenzini in the southern sawshark, Pristiophorus nudipinnis and the longnose sawshark, Pristiophorus cirratus. In both species, the receptive fields of the mechano‐ and electrosensory systems extend the full length of the rostrum indicating that the sawshark rostrum serves a sensory function. Interestingly, despite recent findings suggesting they feed at different trophic levels, minimal interspecific variation between the two species was recorded. Nonetheless, compared to pristids, the pristiophorid rostrum possesses a reduced mechanosensory sampling field but higher electrosensory resolution, which suggests that pristiophorids may not use their rostrums to disable large prey like pristids do.
Evaluation of efficacy of QR678® and QR678® Neo hair growth factor formulation in the treatment of persistent chemotherapy‐induced alopecia caused due to cytotoxic chemotherapy—A prospective pilot study
Authors: Kapoor Rinky , Shome Debraj , Doshi Komal , Vadera Sapna , Patel Ghanshyam , Kumar Vaibhav 
Published: October 2020

ABSTRACTBackgroundCancers are one of the main reasons of morbidity and mortality globally. Chemotherapy‐induced alopecia (CIA) is one of the most alarming, terrifying, and traumatic adverse effects. A range of therapeutic measures has been suggested to alleviate CIA, but at present, there is no accepted pharmacological therapy that can assure prevention or management.AimThe aim of the present study was to evaluate the efficacy of QR 678 Neo® therapy in the treatment of persistent chemotherapy‐induced alopecia in women and men treated with cytotoxic chemotherapy for breast and lung cancers, respectively.MethodsA total of 8 male patients with history of lung cancer and 12 female patients with history of breast cancer in the age range of 25‐60 years, with WHO classification of grade I and II persistent alopecia who had undergone chemotherapy treatment, were selected for the study. At each visit, 1.5 mL solution of QR 678® was injected into the scalp skin of patients. A total of 8 sessions were performed at an interval of 3 weeks each. All the patients were evaluated with standard global photography, video microscopic assessment, and patient self‐assessment questionnaire at baseline, 6 months, and 1 year.ResultsMarked improvement was seen in the global assessment score at 6 months (mean‐8) which was maintained even after 1 year. Mean score increase in hair count at 6 months was 12.71 which further increased at 1 year. High satisfaction score was given by patients for slowing of hair loss (mean = 4.2) and also for overall hair growth. For appearance and growth of hair, the mean value was 3.4 and 3.8, respectively.ConclusionThe formulation of QR 678® and QR 678® Neo showed to be significantly safe and efficient for chemotherapy‐induced alopecia in both men and women. Improvement in hair growth was maintained even at 1 year of follow‐up. No patient had any severe adverse effects, and injections were also easily bearable by most of them.
Consumer preferences for burgers and milk desserts: Evaluating the importance of health claim attributes
Authors: Viana Mayra Monteiro , Polizer Rocha Yana Jorge , Trindade Marco Antonio , Alfinito Solange 
Published: October 2020

AbstractThe question that guided this work was if health claims should receive special attention by evaluating if these claims stand as a relevant attribute to consumers. Thereby, the goal of this work is to explore how consumers deal with different food product attributes, including health claims, in frozen burgers (Study 1), and milk desserts (Study 2) via conjoint analysis (CA). In Study 1, the ranking‐based CA revealed that the attribute “Claim” is more relevant than “Price” and that the Claim level of “Source of Fibres” in burgers is rejected by consumers. In Study 2, the rating‐based CA also reveals “Claim” as the most valued attribute in milk desserts, and consumers reject the Claim level of “Antioxidants” but are favorable to “Fiber”. As conclusions, the claim is the most important attribute in both cases. Still, while consumers did not respond positively regarding frozen burgers with health attributes, there was a positive asset for milk desserts.Practical ApplicationsThe manuscript brings a contribution to the field of food consumer studies by assessing claim attributes in different ways in terms of products, designs, and conjoint methods. The information obtained in this study brings useful insights regarding the importance of claims in consumer preference. One example is the discussions regarding some cautions that food industries should have regarding functional claims, as some levels were rejected in both carriers. Through this study, it is possible to disseminate the importance of gaining understandings regarding claims in functional foods, and especially regarding Brazilian consumers.
Heterogeneous Layoff Effects of the US Short‐Time Compensation Program
Authors: Tracey Marlon R. , Polachek Solomon W. 
Published: October 2020

AbstractThe Short‐Time Compensation (STC) program enables US firms to reduce work hours via pro‐rated Unemployment Insurance (UI) benefits, rather than relying on layoffs as a cost‐cutting tool. Despite the program's potential to preclude skill loss and rehiring/retraining costs, firms' participation rates are still very low in response to economic downturns. Using firm‐level UI administrative data and semi‐parametric methods, we show why by illustrating which type of firms benefit from the program and which do not. A key finding is that cyclically sensitive firms have about 14% lower layoff rates when they use STC, but we find no difference for more cyclically stable firms.
Multiple processes contribute to methane emission in a riparian cottonwood forest ecosystem
Authors: Flanagan Lawrence B. , Nikkel Dylan J. , Scherloski Lauren M. , Tkach Rachel E. , Smits Kristian M. , Selinger L. Brent , Rood Stewart B. 
Published: October 2020

Summary

Methane emission from trees may partially or completely offset the methane sink in upland soils, the only process that has been regularly included in methane budgets for forest ecosystems. Our objective was to analyze multiple biogeochemical processes that influence the production, oxidation and transport of methane in a riparian cottonwood ecosystem and its adjacent river.

We combined chamber flux measurements on tree stems, forest soil and the river surface with eddy covariance measurements of methane net ecosystem exchange. In addition, we tested whether methanogens were present in cottonwood stems, shallow soil layers and alluvial groundwater.

Average midday peak in net methane emission measured by eddy covariance was c. 12 nmol m−2 s−1. The average uptake of methane by soils (0.87 nmol m−2 s−1) was largely offset by tree stem methane emission (0.75 nmol m−2 s−1). There was evidence of methanogens in tree stems but not in shallow soil.

Growing season (May–September) cumulative net methane emission (17.4 mmol CH4 m−2) included methane produced in cottonwood stems and methane input to the nocturnal boundary layer from the forest and the adjacent river. The multiple processes contributing to methane emission illustrated the linked nature of these adjacent terrestrial and aquatic ecosystems.
Placental weightZ‐score and pubertal timing: A population‐based cohort study
Authors: Ernst Andreas , Brix Nis , Lunddorf Lea L. H. , Olsen Jørn , Ramlau‐Hansen Cecilia Høst 
Published: October 2020

AbstractBackgroundThe placenta provides nutrients, oxygen, and hormonal support for adequate fetal growth and development of the hormonal axes, which are important for pubertal timing later in life.ObjectivesWe investigated if an indicator of poor placental function, low gestational age‐specificZ‐score for placental weight at birth, was associated with earlier pubertal timing.MethodsThe study is based on a population‐based cohort of 15 195 singleton boys and girls (68% of 22 439 invited) born 20 to 43 weeks of gestation (2000‐2003) nested within the Danish National Birth Cohort. PlacentalZ‐score was estimated from data collected at birth. Between 2012 and 2018, the children returned half‐yearly web‐based questionnaires from age of 11 years on status of the pubertal milestones: Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair. We estimated adjusted monthly differences in mean age at attaining the pubertal milestones and pubertal timing overall with placentalZ‐score continuously and as restricted cubic splines. Further, we explored whether growth by birthweightZ‐score and body mass indexZ‐score around 7 years mediated the associations.ResultsPlacentalZ‐score was positively associated with age at attaining most of the pubertal milestones in girls, particularly for age at menarche, but not in boys. Effect sizes were modest, and when combining all pubertal milestones, one standard deviation increase in placentalZ‐score was associated with 0.5 months (95% confidence interval [CI] 0.2, 0.9) later pubertal timing overall in girls. The associations in girls were largely mediated through fetal growth.ConclusionsAssuming that placentalZ‐score correlates with placental function, these findings suggest that placental dysfunction (low placentalZ‐score) advances pubertal timing in girls slightly by reducing fetal growth. Future studies need to evaluate whether placental weight sufficiently captures intrauterine growth of importance for pubertal development and search for other potential candidates reflecting placental function.
Factors associated with non‐nutritive sucking habits at 2 years of age among very preterm children: EPIPAGE‐2 cohort study
Authors: Herrera Sandra , Pierrat Véronique , Kaminski Monique , Benhammou Valérie , Bonnet Anne‐Laure , Ancel Pierre‐Yves , Germa Alice 
Published: October 2020

AbstractBackgroundThe association between prolonged non‐nutritive sucking habits (NNSHs, ie, sucking pacifiers or fingers) and maxillofacial growth anomalies in the general population has been widely described. Because maturation of sucking abilities is not fully achieved in very preterm infants (<32 weeks’ gestation), neonatal services worldwide rely on the use of pacifiers to promote the development of adequate sucking reflexes, possibly prolonging NNSHs during infancy.ObjectiveWe aimed to describe the frequency and to identify factors associated with NNSHs at age 2 years in very preterm children.MethodsThe study was based on data from EPIPAGE‐2, a French national prospective cohort study of preterm births during 2011 that included 2593 children born between 24 and 31 weeks’ gestation. The primary outcome was NNSHs at 2 years. Multivariable log‐linear regression models with generalized estimation equations were used to study the association between the characteristics studied and NNSHs. Multiple imputations were used to take into account missing data.ResultsThe frequency of NNSHs was 69% in the overall sample but higher among girls (adjusted risk ratio [RR] 1.12, 95% confidence interval [CI] 1.05, 1.17), children born from multiple pregnancies (eg, twins/triplets) (RR 1.07, 95% CI 1.00, 1.11), children who were fed by nasogastric tube (RR 1.07, 95% CI 1.01, 1.13), or those who benefitted from developmental care programmes (RR 1.10, 95% CI 1.02, 1.19). The NNSHs frequency was lower if mothers were not born in France (RR 0.70, 95% CI 0.64, 0.77), children had 2 or more older siblings (RR 0.88, 95% CI 0.82, 0.96), or children were breast‐fed at discharge (RR 0.90, 95% CI 0.85, 0.95).ConclusionsNNSHs at 2 years seemed associated with cultural background, development care programmes, and breast feeding. Whether NNSHs at 2 years among very preterm children are associated with future maxillofacial growth anomalies deserves further attention.
Successful treatment of Ophionyssus natricis with afoxolaner in two Burmese pythons (Python molurus bivittatus)
Authors: Fuantos Gámez Braulio A. , Romero Núñez Camilo , Sheinberg Waisburd Galia , Bautista Gómez Linda G. , Yarto Jaramillo Enrique , Heredia Cardenas Rafael , Miranda Contreras Laura 
Published: October 2020

RésuméL'efficacité de l'afoxolaner a été évaluée chez deux serpents python birmans captifs, naturellement infestés par des acariens Ophionyssus natricis. L'administration d'une dose orale unique d'afoxolaner a éliminé les acariens O. natricis vivants des deux serpents à jour 3. Les échantillons environnementaux prélevés dans les terrariums des serpents étaient négatifs pour les acariens morts à jour 30.
hsa_circ_001653 up‐regulates NR6A1 expression and elicits gastric cancer progression by binding to microRNA‐377
Authors: Zhou Wuyuan , Jiang Rongke , Wang Yu , Li Yanfang , Sun Ziqian , Zhao Hongying 
Published: October 2020

New Findings
What is the central question of this study?Does hsa_circ_001653 influence the development of gastric cancer (GC) and if so how?
What is the main finding and its importance?Bioinformatics analysis revealed the presence of differentially expressed hsa_circ_001653 in GC and adjacent normal tissues, and this was strongly related to the pathology of patients with GC. Knockdown of hsa_circ_001653 suppressed the proliferation, invasion and migration of GC cells, while inducing cell apoptosis via miR‐377‐mediated NR6A1 inhibition. The effect of hsa_circ_001653 and miR‐377 on tumour growth in GC was further confirmed in vivo.
AbstractGastric cancer (GC) is one of the leading causes of human mortality through malignant tumours. Circular RNAs (circRNAs) have been identified as binding to microRNAs (miRNAs) to modulate the progression of tumours. This study explores the role of hsa_circ_001653, a newly identified circRNA, in the development of GC. hsa_circ_001653 expression was measured in 86 paired normal and tumour tissues surgically resected from GC patients. Cross‐talk between hsa_circ_001653 and microRNA‐377 (miR‐377)/nuclear receptor subfamily 6, group A, member 1 (NR6A1) was assessed using bioinformatics analysis, dual‐luciferase reporter assay, Ago2 immunoprecipitation and western blot analysis. A series of functional experiments were carried out to elucidate the role of hsa_circ_001653 in GC cell proliferation, invasion, migration and apoptosis, and its underlying molecular mechanisms. Nude mice were inoculated with GC cells for in vivo analysis. hsa_circ_001653 was found to be an up‐regulated circRNA in GC tissues and cells. Down‐regulation of hsa_circ_001653 inhibited GC cell proliferation, migration and invasion, while stimulating cell apoptosis. hsa_circ_001653 was found to bind to miR‐377, which targeted NR6A1 and repressed its expression. Inhibition of miR‐377 and overexpression of NR6A1 restored the proliferation, migration and invasion in GC cells lacking hsa_circ_001653. Furthermore, inhibition of hsa_circ_001653 attenuated tumour growth in nude mice inoculated with GC cells. Collectively, the demonstration that hsa_circ_001653 exerts its anticancer effects by regulating the miR‐377–NR6A1 axis increases our understanding of gastric cancer pathophysiology. The findings uncover new potential therapeutic targets for GC.
Reproductive management of seasonal calving dairy herds
Authors: Lindley George , Willshire Jim 
Published: October 2020

BackgroundSeasonal calving herds account for around a fifth of dairy farms in the UK (AHDB 2016). Their structure allows focused farm management and seasonal labour requirements, as well as the opportunity to maximise the conversion of grazed grass into milk. However, their economic success is underpinned by a requirement for optimal reproductive management, and for this reason a thorough understanding of how to approach fertility in these herds is essential for veterinary surgeons involved in their management.Aim of the articleThis article explains the concept of seasonal calving systems, the impacts of poor fertility, the key performance indicators used to monitor performance in clinical practice, and the key areas where improvements can be made.
Treatment of Multiple Myeloma Using Chimeric Antigen Receptor T Cells with Dual Specificity
Authors: Globerson Levin Anat , Rawet Slobodkin Moran , Waks Tova , Horn Galit , Ninio-Many Lihi , Deshet Unger Naamit , Ohayon Yaara , Suliman Shimrit , Cohen Yael , Tartakovsky Boris , Naparstek Ella , Avivi Irit , Eshhar Zelig 
Published: October 2020

Abstract
Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable successes in fighting B-cell leukemias/lymphomas. Promising response rates are reported in patients treated with B-cell maturation antigen (BCMA) CAR T cells for multiple myeloma. However, responses appear to be nondurable, highlighting the need to expand the repertoire of multiple myeloma–specific targets for immunotherapy and to generate new CAR T cells. Here, we developed a “dual-CAR” targeting two multiple myeloma–associated antigens and explored its safety and efficacy. To reduce the “off-target” toxicity, we used the recognition of paired antigens that were coexpressed by the tumor to induce efficient CAR T-cell activation. The dual-CAR construct presented here was carefully designed to target the multiple myeloma–associated antigens, taking into consideration the distribution of both antigens on normal human tissues. Our results showed that the CD138/CD38-targeted dual CAR (dCAR138-38) elicited a potent anti–multiple myeloma response both in vitro and in vivo. NSG mice transplanted with a multiple myeloma cell line and treated with dCAR138-38 showed median survival of 97 days compared with 31 days in the control group treated with mock-lymphocytes. The dCAR138-38 showed increased specificity toward cells expressing both targeted antigens compared with single-antigen–expressing cells and low activity toward primary cells from healthy tissues. Our findings indicated that the dCAR138-38 may provide a potent and safe alternative therapy for patients with multiple myeloma.
The Pilgrimage Landscape in Contemporary Estonia: New Routes, Narratives, and Re-Christianization
Authors: Sepp Tiina , Remmel Atko 
Published: October 2020

Abstract
This article is the first attempt at mapping the pilgrimage landscape in contemporary Estonia, reputedly one of the most secularized countries in Europe. Based on fieldwork on three case studies — the Estonian Society of the Friends of the Camino de Santiago, the Pirita-Vastseliina pilgrim trail, and the “Mobile Congregation” — we have identified three distinctive features that shape the Estonian pilgrimage scene. The processes of Caminoization and heritagization characterize pilgrimage on a European scale, while the phenomenon that we call “bridging” has a more local flavor. Bridging refers to using pilgrimage to create connections between the Church (of any Christian denomination) and “secular” people. Historically a Christian practice, pilgrimage has transformed into something much more ambiguous. Thus, people often perceive pilgrimage as religion-related but still inherently secular. As the relationships between institutionalized religion and the vernacular world of beliefs and practices are multivalent, there is evidence of an ongoing “re-Christianization” of pilgrimage.
Weekend Couples as a Manifestation of Gender Equality?
Authors: Lee Yun-Suk 
Published: October 2020

Abstract
Some wives and husbands maintain separate residences. This form of couple is understood as a major transition in the gender arrangement of work and family. Using a sample of “weekend couples,” where Korean wives and husbands live separately, this study (1) compared weekend and typical couples in time spent on housework, and (2) examined whether time on housework is associated with life satisfaction in weekend and typical couples. I found that, while women in weekend couples spend much less time on household chores compared to women in typical couples, men in weekend couples assign more time to housework compared to their counterparts. Additionally, I found that, for women in both weekend and typical couples, more household tasks are related to lower levels of general satisfaction. The results suggest that maintaining separate residences may balance time use patterns between two partners, which could have important implications for the subjective well-being of weekend couples.