bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotergestützte Bauchspeicheldrüsenchirurgie
Authors: Müller-Debus Charlotte Friederieke , Thomaschewski Michael , Zimmermann Markus , Wellner Ulrich Friedrich , Keck Tobias 
Published: June 2020

Zusammenfassung
Einführung Der Einsatz von Robotern in der minimalinvasiven Chirurgie hat in den letzten Jahren immer weiter zugenommen. Die roboterunterstützte Pankreaschirurgie hat gegenüber der laparoskopischen Pankreaschirurgie den Vorteil einer besseren Handhabung und verbesserten Angulation durch die größere Flexibilität der Instrumente. Darüber hinaus besteht durch die 3-D-Technik eine verbesserte Sicht und durch eine softwarebasierte Tremorkontrolle eine exakte Instrumentenführung. Die körperliche Belastung des Chirurgen durch die sitzende Position ist bei langen Eingriffen geringer.
Methoden und Ergebnisse Dieser Artikel liefert einen Ansatz für die Einrichtung eines Roboter-Pankreas-Programms und eine detaillierte Anleitung im Sinne von SOPs für die robotergestützte Pankreaslinksresektion und robotergestützte Pankreatoduodenektomie.
Ergebnisse In unserem standardisierten SOP-Ansatz verwenden wir sowohl bei der Pankreaslinksresektion als auch bei der Pankreatduodenektomie jeweils 5 Trokare – 4 Da-Vinci-Trokare und einen laparoskopischen Hilfstrokar. Wir bevorzugen die Position der Robotertrokare auf einer geraden horizontalen Linie mit einem Abstand von etwa 20 cm vom Operationsfeld. Die Operation wird in standardisierten Arbeitsschritten durchgeführt. Bei der Pankreaslinksresektion sind dies: Zugang und Visualisierung des Pankreas, Mobilisierung der linken Dickdarmflexur und des Pankreasunterrandes, Präparation der V. lienalis und der mesenterikoportalen Achse, Präparation des Pankreasoberrandes mit Lymphadenektomie und Darstellung der A. lienalis, Durchtrennung des Pankreas, retrograde Präparation des Pankreas und der Milz (bei onkologischen Eingriffen). Bergung, Einlage von Drainagen und Wundverschluss. Bei der Pankreatoduodenektomie sind es folgende Schritte: Zugang und Visualisierung des Pankreas, erweitertes Kocher-Manöver, Darstellung der Unterkante und der mesenterikoportalen Achse, Darstellung des Pankreasoberrandes und des Lig. hepatoduodenale, Präparation des Pankreashalses, Darstellung der Mesenterialwurzel und Pars IV duodeni, Präparation des Mesopankreas, Durchführung der Pankreasanastomose und der biliodigestiven Anastomose, Naht der dudenojejunalen Anastomose, Einlage von Drainagen und schichtweiser Wundverschluss. Der graduelle Aufbau unseres Roboter-Pankreas-Programms und der strukturierte Ansatz für komplexe Pankreasresektionen werden erläutert.
Zusammenfassung Zusammenfassend beschreiben wir den Ansatz der robotischen Bauchspeicheldrüsenchirurgie in einem minimalinvasiven Exzellenzzentrum und Bauchspeicheldrüsenzentrum auf struktureller und verfahrenstechnischer Ebene, um die Einrichtung derartiger Programme an anderen Standorten zu unterstützen.
Endoscopic full-thickness resection (eFTR) of colorectal lesions: results from the Dutch colorectal eFTR registry
Authors: Zwager Liselotte W. , Bastiaansen Barbara A. J. , Bronzwaer Maxime E. S. , van der Spek Bas W. , Heine G. Dimitri N. , Haasnoot Krijn J. C. , van der Sluis Hedwig , Perk Lars E. , Boonstra Jurjen J. , Rietdijk Svend T. , Wolters Hugo J. , Weusten Bas L. A. M. , Gilissen Lennard P. L. , ten Hove W. Rogier , Nagengast Wouter B. , Bekkering Frank C. , Schwartz M. P. , Terhaar sive Droste Jochim S. , Vlug Marije S. , Houben Martin H. M. G. , Rando Munoz Francisco J. , Seerden Tom C. J. , Beaumont Hanneke , de Ridder Rogier , Dekker Evelien , Fockens Paul ,   on behalf of the Dutch eFTR Group
Published: June 2020

Abstract
Background Endoscopic full-thickness resection (eFTR) is a minimally invasive resection technique that allows definite diagnosis and treatment for complex colorectal lesions ≤ 30 mm unsuitable for conventional endoscopic resection. This study reports clinical outcomes from the Dutch colorectal eFTR registry.
Methods Consecutive patients undergoing eFTR in 20 hospitals were prospectively included. The primary outcome was technical success, defined as macroscopic complete en bloc resection. Secondary outcomes were: clinical success, defined as tumor-free resection margins (R0 resection); full-thickness resection rate; and adverse events.
Results Between July 2015 and October 2018, 367 procedures were included. Indications were difficult polyps (non-lifting sign and/or difficult location; n = 133), primary resection of suspected T1 colorectal cancer (CRC; n = 71), re-resection after incomplete resection of T1 CRC (n = 150), and subepithelial tumors (n = 13). Technical success was achieved in 308 procedures (83.9 %). In 21 procedures (5.7 %), eFTR was not performed because the lesion could not be reached or retracted into the cap. In the remaining 346 procedures, R0 resection was achieved in 285 (82.4 %) and full-thickness resection in 288 (83.2 %). The median diameter of resected specimens was 23 mm. Overall adverse event rate was 9.3 % (n = 34/367): 10 patients (2.7 %) required emergency surgery for five delayed and two immediate perforations and three cases of appendicitis.
Conclusion eFTR is an effective and relatively safe en bloc resection technique for complex colorectal lesions with the potential to avoid surgery. Further studies assessing the role of eFTR in early CRC treatment with long-term outcomes are needed.
Serum Inflammatory Cytokines and Vitamin A in Nigerian Children with Community-Acquired Pneumonia: Association with Severity and Outcome
Authors: Kuti Bankole P. , Smith Olufemi S. , Adetola Hammed H. , Oyelami Oyeku A. 
Published: June 2020

AbstractObjective Pneumonia is an acute inflammation of the lung parenchyma caused by microbial agents. The role of inflammatory mediators and modulators like vitamin A in childhood pneumonia in developing countries is poorly explored. The aim of this study is to determine the relationship between serum vitamin A and inflammatory cytokines (i.e., proinflammatory interleukins [IL]-1β, -2, -3, -6, -8, -12, and -17 and anti-inflammatory IL-4, -10, -11, and -13) in Nigerian children with community-acquired pneumonia (CAP) and relate these to pneumonia severity and length of hospital stay (LOS).Methods Children aged 2 months to 14 years with World Health Organization (WHO) defined CAP and age and sex-matched controls were recruited over a 12-month period. Relevant data, serum cytokines, and vitamin A (assayed using chromatography method) were compared between the two groups, and between those with severe and nonsevere pneumonia. Relationships between serum vitamin A, cytokines, and LOS were also determined.Results One hundred and thirty-two children (66 each for CAP and controls; M: F = 1.8:1) were recruited and 17 (12.9%) were vitamin-A deficient. Of the 66 with CAP, 52 (78.8%) had severe pneumonia. Serum proinflammatory cytokines (IL-6, -8, -12, and -17) and anti-inflammatory cytokines (IL-4 and -11) were higher in children with CAP compared with controls. In under-five age group, lower serum IL-4 and vitamin A were associated with severe CAP. Vitamin-A deficient children with CAP had lower proinflammatory cytokines (IL-1β, IL-2, -3, -12, and -17) and anti-inflammatory cytokine IL-4 than vitamin A sufficient ones. IL-6 and IL-8 correlated positively with LOS.Conclusion CAP is associated with elevated serum proinflammatory cytokines and possible resultant higher need of antioxidants properties of vitamin A in severe cases. Vitamin A may be more important to ameliorate the acute inflammatory processes in Nigerian children with severe than nonsevere pneumonia.
A processability approach to the development of case in L2 Icelandic
Authors: Garðarsdóttir María , Þorvaldsdóttir Sigríður 
Published: June 2020

AbstractThis article presents the findings of a study on the development of case assignment in Icelandic as a second language within the context of Processability Theory (PT) and compares them with previous PT studies on the development of case in L2 German, Russian, and Serbian. We argue that initially, learners are only able to appropriately mark subjects and objects in canonical positions (e.g.,subjnomv objacc). Later they are also able to mark arguments with the appropriate case in sentences that deviate from canonical word order (e.g.,objacc/datv subjnom). In order to examine the case development in L2 Icelandic, 148 learners were asked to fill in the blanks of sentences with missing core arguments. Our results replicate for the most part the previous findings for L2 German, Russian, and Serbian. As such, the present study adds to the typological plausibility of PT as a framework that predicts and explains developmental sequences.
Critical heat current for operating an entanglement engine
Authors: Khandelwal Shishir , Palazzo Nicolas , Brunner Nicolas , Haack Géraldine 
Published: June 2020

Abstract
Autonomous entanglement engines have recently been proposed to generate steady-state bipartite and multipartite entanglement exploiting only incoherent interactions with thermal baths at different temperatures. In this work, we investigate the interplay between heat current and entanglement in a two-qubit entanglement engine, deriving a critical heat current for successful operation of the engine, i.e. a cut-off above which entanglement is present. The heat current can thus be seen as a witness to the presence of entanglement. In the regime of weak-inter-qubit coupling, we also investigate the effect of two experimentally relevant parameters for the qubits, the energy detuning and tunnelling, on the entanglement production. Finally, we show that the regime of strong inter-qubit coupling provides no clear advantage over the weak regime, in the context of out-of-equilibrium entanglement engines.
Two-dimensional spectroscopy of Rydberg gases
Authors: Mukherjee K , Goswami H P , Whitlock S , Wüster S , Eisfeld A 
Published: June 2020

Abstract
Two-dimensional (2D) spectroscopy uses multiple electromagnetic pulses to infer the properties of a complex system. A paradigmatic class of target systems are molecular aggregates, for which one can obtain information on the eigenstates, various types of static and dynamic disorder and on relaxation processes. However, two-dimensional spectra can be difficult to interpret without precise knowledge of how the signal components relate to microscopic Hamiltonian parameters and system-bath interactions. Here we show that two-dimensional spectroscopy can be mapped in the microwave domain to highly controllable Rydberg quantum simulators. By porting 2D spectroscopy to Rydberg atoms, we firstly open the possibility of its experimental quantum simulation, in a case where parameters and interactions are very well known. Secondly, the technique may provide additional handles for experimental access to coherences between system states and the ability to discriminate different types of decoherence mechanisms in Rydberg gases. We investigate the requirements for a specific implementation utilizing multiple phase coherent microwave pulses and a phase cycling technique to isolate signal components.
Will climate change make Chinese people more comfortable? A scenario analysis based on the weather preference index
Authors: Fang Zihang , Liu Zhifeng , He Chunyang , Tu Mengzhao , Zhao Rui , Lu Wenlu 
Published: June 2020

Abstract
Assessing the climate change impact (CCI) on weather conditions is important for addressing climate change and promoting sustainable development. This study used a weather preference index (WPI) as an indicator to evaluate the CCI on weather conditions in China under different scenarios from 2025 to 2100. First, we analyzed the change in the WPI in China from 1971 to 2013. Then, we estimated the trends in the WPI in China from 2025 to 2100 under different representative concentration pathways (RCPs) based on global climate models. We found that China’s weather conditions improved from 1971 to 2013, as the national average WPI increased from 1.34 to 1.59 with a change rate of 0.03 per decade (0.03/10 a). Under all climate change scenarios, the weather conditions in China will deteriorate. The change rates of the WPI will be −0.19/10 a ∼ − 0.01/10 a. The number of people experiencing deteriorated weather conditions will be 0.71 billion ∼ 1.22 billion, accounting for 53.28% ∼ 91.58% of the total population in China. We also found that the area of the regions with deteriorated weather conditions under all three climate change scenarios will be 2.34 million km2, accounting for 24.31% of China’s total land area. At the same time, as the emissions concentrations increase from RCP2.6 to RCP8.5, the area of the regions with severely deteriorated weather conditions in China will increase from 0 to 3.27 million km2. Therefore, we suggest that China needs to implement effective measures to address climate change in the future and focus on the mitigation of and adaptation to climate change in regions with deteriorated weather conditions.
Dietary Fat Intake and Risk of Uterine Leiomyomata: A Prospective Ultrasound Study
Authors: Brasky Theodore M , Bethea Traci N , Wesselink Amelia K , Wegienka Ganesa R , Baird Donna D , Wise Lauren A 
Published: June 2020

Abstract
Uterine leiomyomata (UL) are associated with severe reproductive morbidity and are the primary indication for hysterectomy in the United States. A recent prospective cohort study of Black women reported positive associations between intakes of marine-sourced ω-3 fatty acids and UL risk. We examined whether intakes of dietary fat were associated with UL incidence in a 5-year prospective study of premenopausal Black women living in Detroit who underwent serial ultrasound. At baseline (2010–2012) and 20, 40, and 60 months of follow-up, participants underwent transvaginal ultrasound. Among 1,171 UL-free women at baseline, incident UL were detected in 277 women. Cox regression was used to estimate hazard ratios and 95% confidence intervals for the association of dietary fat and UL incidence. Intakes of total fat and saturated, monounsaturated, polyunsaturated, and trans-fat were not appreciably associated with UL incidence. Intake of the marine ω-3 polyunsaturated fatty acid, docosahexaenoic acid, was associated with 49% higher UL incidence (quartile 4 vs. 1: hazard ratio = 1.49, 95% confidence interval: 1.04, 2.14; P for trend = 0.01). Intakes of total marine ω-3 polyunsaturated fatty acids were similarly associated with elevated UL incidence (hazard ratio = 1.35, 95% confidence interval: 0.94, 1.93; P for trend = 0.03). It remains unclear whether the fatty acids or persistent environmental pollutants drive the association.
Genome-wide circadian rhythm detection methods: systematic evaluations and practical guidelines
Authors: Mei Wenwen , Jiang Zhiwen , Chen Yang , Chen Li , Sancar Aziz , Jiang Yuchao 
Published: June 2020

Abstract
Circadian rhythms are oscillations of behavior, physiology and metabolism in many organisms. Recent advancements in omics technology make it possible for genome-wide profiling of circadian rhythms. Here, we conducted a comprehensive analysis of seven existing algorithms commonly used for circadian rhythm detection. Using gold-standard circadian and non-circadian genes, we systematically evaluated the accuracy and reproducibility of the algorithms on empirical datasets generated from various omics platforms under different experimental designs. We also carried out extensive simulation studies to test each algorithm’s robustness to key variables, including sampling patterns, replicates, waveforms, signal-to-noise ratios, uneven samplings and missing values. Furthermore, we examined the distributions of the nominal $P$-values under the null and raised issues with multiple testing corrections using traditional approaches. With our assessment, we provide method selection guidelines for circadian rhythm detection, which are applicable to different types of high-throughput omics data.
Incorporating Biterm Correlation Knowledge into Topic Modeling for Short Texts
Authors: Zhang Kai , Zhou Yuan , Chen Zheng , Liu Yufei , Tang Zhuo , Yin Li , Chen Jihong 
Published: June 2020

Abstract
The prevalence of short texts on the Web has made mining the latent topic structures of short texts a critical and fundamental task for many applications. However, due to the lack of word co-occurrence information induced by the content sparsity of short texts, it is challenging for traditional topic models like latent Dirichlet allocation (LDA) to extract coherent topic structures on short texts. Incorporating external semantic knowledge into the topic modeling process is an effective strategy to improve the coherence of inferred topics. In this paper, we develop a novel topic model—called biterm correlation knowledge-based topic model (BCK-TM)—to infer latent topics from short texts. Specifically, the proposed model mines biterm correlation knowledge automatically based on recent progress in word embedding, which can represent semantic information of words in a continuous vector space. To incorporate external knowledge, a knowledge incorporation mechanism is designed over the latent topic layer to regularize the topic assignment of each biterm during the topic sampling process. Experimental results on three public benchmark datasets illustrate the superior performance of the proposed approach over several state-of-the-art baseline models.
Historic and contemporary use of catfish aquaculture by piscivorous birds in the Mississippi Delta
Authors: Burr Paul C , Avery Jimmy L , Street Garrett M , Strickland Bronson K , Dorr Brian S 
Published: June 2020

AbstractPiscivorous birds are the primary source of catfish (Ictalurus spp.) depredation at aquaculture facilities in northwestern Mississippi. Of particular concern is the Double-crested Cormorant (Phalacrocorax auritus), which can cost aquaculture producers millions of dollars annually through the depredation of cultured fish. Historical research conducted in the early 2000s estimated cormorant use of aquaculture ponds in the region, but aquaculture area has decreased by more than 70% since those estimates were made. With less aquaculture available, we predicted cormorant densities on aquaculture would be greater today than historically. Applying a similar methodology as in historical studies, we used aerial surveys to collect data on cormorants at night roosts and using catfish aquaculture ponds during 3 consecutive winter seasons, beginning in 2015. Although the mean annual number of cormorants at roosts in the Delta during our study was 64% less than historically, we found no significant change in densities on aquaculture, suggesting that aquaculture area is likely the factor influencing cormorant occurrence in northwestern Mississippi. During contemporary surveys we also measured the abundance of Great Blue Herons (Ardea herodias) and Great Egrets (A. alba) on the aquaculture clusters, and built predictive models of abundance relative to variables associated with forage at and surrounding the clusters. We found abundance of all 3 species was strongly related to the amount of aquaculture area both within and surrounding a cluster, although patterns varied by species. Cormorant abundance was also greater on clusters with proportionately more food fish (≥20 cm in length) than fingerlings (&lt;20 cm) and was positively related to the proximity and size of night roosts. The relationships described here can be used by producers and wildlife managers to predict the abundance of these piscivorous birds at aquaculture facilities and to design efficient management plans to mitigate potential impacts of depredation and disease.
Dilated cardiomyopathy-linked heat shock protein family D member 1 mutations cause up-regulation of reactive oxygen species and autophagy through mitochondrial dysfunction
Authors: Enomoto Hirokazu , Mittal Nishant , Inomata Takayuki , Arimura Takuro , Izumi Tohru , Kimura Akinori , Fukuda Keiichi , Makino Shinji 
Published: June 2020

Abstract

Aims
During heart failure, the levels of circulatory heat shock protein family D member 1 (HSP60) increase. However, its underlying mechanism is still unknown. The apical domain of heat shock protein family D member 1 (HSPD1) is conserved throughout evolution. We found a point mutation in HSPD1 in a familial dilated cardiomyopathy (DCM) patient. A similar point mutation in HSPD1 in the zebrafish mutant, nbl, led to loss of its regenerative capacity and development of pericardial oedema under heat stress condition. In this study, we aimed to determine the direct involvement of HSPD1 in the development of DCM.

Methods and results
By Sanger method, we found a point mutation (Thr320Ala) in the apical domain of HSPD1, in one familial DCM patient, which was four amino acids away from the point mutation (Val324Glu) in the nbl mutant zebrafish. The nbl mutants showed atrio-ventricular block and sudden death at 8-month post-fertilization. Histological and microscopic analysis of the nbl mutant hearts showed decreased ventricular wall thickness, elevated level of reactive oxygen species (ROS), increased fibrosis, mitochondrial damage, and increased autophagosomes. mRNA and protein expression of autophagy-related genes significantly increased in nbl mutants. We established HEK293 stable cell lines of wild-type, nbl-type, and DCM-type HSPD1, with tetracycline-dependent expression. Compared to wild-type, both nbl- and DCM-type cells showed decreased cell growth, increased expression of ROS and autophagy-related genes, inhibition of the activity of mitochondrial electron transport chain complexes III and IV, and decreased mitochondrial fission and fusion.

Conclusion
Mutations in HSPD1 caused mitochondrial dysfunction and induced mitophagy. Mitochondrial dysfunction caused increased ROS and cardiac atrophy.
Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn’s Disease Patients: A Case Report and Review of the Literature
Authors: Thomas Pepijn W A , Ferwerda Gerben , West Rachel L , Hoentjen Frank 
Published: June 2020

Abstract
Recently, ustekinumab has been approved for the treatment of Crohn’s disease and ulcerative colitis. Treatment is started with an intravenous induction dose, followed by a subcutaneous dosage. We present details of three patients with therapy-refractory Crohn’s disease who experienced an immediate infusion reaction to intravenous administration of ustekinumab. In two of these patients a subsequent reaction to subcutaneous injections occurred. Clinical features and pathophysiology are discussed.