bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of thermoplastic morphology on mechanical properties in laser-assisted joining of polyamide 6 with aluminum
Authors: Schricker Klaus , Bergmann Jean Pierre , Hopfeld Marcus , Spieß Lothar 
Published: December 2020

AbstractThis paper examined the joining zone between semi-crystalline polyamide 6 and aluminum EN AW 6082 in laser-based joining and evaluated the mechanical properties of the joint. The joint tests were carried out in overlap configuration and a characterized in terms of energy per unit length. The mechanical properties were examined to the point of cohesive failure. An increasing energy per unit length resulted in a reduced crosshead displacement in short-term testing and a decreased fatigue strength. Further material testing was carried out locally at various positions within the joining zone. The mechanical properties were correlated with results of a hardness test, thermoplastic morphology, differential scanning calorimetry (DSC), and X-ray diffraction (XRD). By combining the findings with heat-treated samples at elevated temperatures, secondary crystallization was identified and evidenced as a primary effect among the changes in mechanical properties due to the heat treatment of the thermoplastic material.
WEIGHTED COMPOSITION OPERATORS BETWEEN LORENTZ SPACES
Authors: LO CHING-ON , LOH ANTHONY WAI-KEUNG 
Published: December 2020

AbstractWe investigate the boundedness, compactness, invertibility and Fredholmness of weighted composition operators between Lorentz spaces. It is also shown that the classes of Fredholm and invertible weighted composition maps between Lorentz spaces coincide when the underlying measure space is nonatomic.
Is Power Noumenal in Nature?
Authors: Besch Thomas M. 
Published: December 2020

ABSTRACTThis paper engages Rainer Forst's doctrine of noumenal power. At the centre of this doctrine is its signature claim that power is noumenal in nature. I reconstruct Forst's definition of power and distinguish three conceptions of noumenal power in his writings. I argue that, on each conception, we should reject that claim. It emerges that the professed noumenality of power is either a trivial feature of power, or else a feature only of some forms of power. Consequently, Forst's definition of power cannot be adequate and the claim that power is noumenal in nature is either trivial or false.
Mysticism without the Mustikos? Some Reflections on Stephen Palmquist’s Mystical Kant
Authors: Medhananda (Ayon Maharaj) Swami 
Published: December 2020

AbstractThis article critically examines some of the main arguments of Stephen Palmquist’s Kant and Mysticism. While I agree with Palmquist that Kant admits the possibility of certain indirect forms of mystical experience, I argue that Palmquist makes Kant out to be more of a mystic than he actually was. In particular, I contend that Palmquist fails to provide convincing justification of two of his main claims: (1) that Kant was a mystic or at least had strong mystical tendencies and (2) that some of the experiences that are central to Kant’s philosophy are best understood as mystical experiences.
The Location of the Earth's Magnetic Poles From Circum‐Terrestrial Observations
Authors: Regi M. , Di Mauro D. , Lepidi S. 
Published: December 2020

AbstractThe magnetic poles or dip poles are the points on the Earth's surface and circum‐terrestrial area where the magnetic field is vertical, so the horizontal component vanishes. They are not coincident with geomagnetic poles, which are the points where the dipole axis, obtained by analytic models, intersects the Earth's surface, and their instrumental sampling determination from ad hoc ground surveys is difficult due to the harsh environmental conditions and remoteness of the areas where they are located. In this work, we use magnetic field measurements from ESA's Swarm satellites covering 5 years (2015–2019), and determine the position of the magnetic poles by modeling the yearly average horizontal magnetic field component through analytic two‐dimensional Taylor polynomial fit and finding the locations where this component is minimum. The yearly dip poles positions at average satellites geocentric altitudes are also projected at ground level based on WGS84 geodetic reference system. Reliability of our method is evaluated by an optimized Monte Carlo test applied to combined International Geomagnetic Reference Field (IGRF) model and Swarm data. The availability of several years of data allows us to investigate the long term variation and dynamics of the magnetic poles, also in comparison with the results provided by IGRF model (both IGRF12 and IGRF13). Our results agree with the model, in better accordance in the north hemisphere with IGRF13, indicating that both magnetic poles move in the north‐west direction, with a speed of ∼37–72 km/y (lower in year 2016) for the north dip pole and of ∼5–9 km/y for the south one.
Laboratory Experiments Contrasting Growth of Uniformly and Nonuniformly Spaced Hydraulic Fractures
Authors: Gunaydin Delal , Peirce Anthony P. , Bunger Andrew P. 
Published: December 2020

AbstractHydraulic fractures that grow in close proximity to one an other interact and compete for fluid that is injected to the wellbore, leading to dominance of some fractures and suppression of others. This phenomenon is ubiquitously encountered in stimulation of horizontal wells in the petroleum industry and it also bears possible relevance to emplacement of multiple laterally propagating swarms of magma‐driven dykes. Motivated by a need to validate mechanical models, this paper focuses on laboratory experiments and their comparison to simulation results for the behavior of multiple, simultaneously growing hydraulic fractures. The experiments entail the propagation of both uniformly and nonuniformly spaced hydraulic fractures by injection of glucose or glycerin‐based solutions into transparent (polymethyl methacrylate) blocks. Observed fracture growth is then compared to predictions of a fully coupled, parallel‐planar 3D hydraulic fracturing simulator. Results from experiments and simulations confirm the suppression of inner fractures when the spacing between the fractures is uniform. For certain non‐uniform spacing, both experiments and simulations show mitigated suppression of the central fractures. Specifically, the middle fracture in a 5‐fracture array grows nearly equally to the outer fractures from the beginning of injection. Furthermore, with some delay, the other two fractures that are suppressed with uniformly spaced configurations grow, and eventually achieve a velocity exceeding the other three fractures in the array. Hence, these experiments give the first laboratory evidence of a model‐predicted behavior wherein certain nonuniform fracture spacings result in drastic increases in the growth of all fractures within the array.
Detection of parvovirus mRNAs as markers for viral activity in endomyocardial biopsy-based diagnosis of patients with unexplained heart failure
Authors: Pietsch Heiko , Escher Felicitas , Aleshcheva Ganna , Lassner Dirk , Bock Claus-Thomas , Schultheiss Heinz-Peter 
Published: December 2020

AbstractErythroparvovirus (B19V) genomes have been detected in various organs of infected individuals including endothelial cells of the heart muscle. However, the role of B19V as a causative pathogen of myocardial damage is still unknown. The majority of reports focus on the presence of viral DNA ignoring proof of viral RNAs as important markers for viral activity. During this study, we established (RT-) qPCR to characterize expression of B19V RNAs (NS1 and VP1/2) in endomyocardial biopsies (EMBs) of 576 patients with unexplained heart failure. 403/576 (70%) EMBs were positive for B19V DNA. B19V mRNAs NS1 and/or VP1/2, indicating viral activity, could be detected in 38.5% of B19V DNA positive samples using the newly established B19V RT-PCRs. 22.1% of samples were characterized by only NS1 mRNA detection while 6.0% revealed only VP1/2 mRNA expression. Detection of both intermediates was successful in 10.4% of samples. Applying the molecular testing, our study revealed that a high proportion (38.5%) of B19V DNA positive EMBs was characterized by viral transcriptional activity. Further prospective studies will evaluate relevance of viral transcription intermediates as a diagnostic marker to differentiate between latent B19V infection and clinically relevant transcriptionally active B19V-infection of the heart muscle.
Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes
Authors: Nkadimeng Sanah M. , Steinmann Christiaan M. L. , Eloff Jacobus N. 
Published: December 2020

AbstractPrevalence of major depression in people with chronic heart failure is higher than in normal populations. Depression in heart failure has become a major issue. Psilocybin-containing mushrooms commonly known as magic mushrooms, have been used since ancient times for their mind healing properties. Their safety in cardiovascular disease conditions is not fully known and may pose as a risk for users suffering from these illnesses. Study investigates the effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushrooms use from genus Psilocybe and Panaeolus respectively, in a pathological hypertrophy conditions in which endothelin-1 disorder is a contributor to pathogenesis. We examined the effects of the mushrooms extracts on endothelin-1-induced hypertrophy and tumor necrosis factor-α (TNF- α)-induced cell injury in H9C2 cardiomyocytes. Mushrooms were oven dried and extracted with cold and boiling-hot water. H9C2 cardiomyocytes were induced with endothelin-1 prior to treatment with extracts over 48 h. Cell injury was stimulated with TNF-α. Results proposed that the water extracts of Panaeolus cyanescens and Psilocybe cubensis did not aggravate the pathological hypertrophy induced by endothelin-1 and also protected against the TNF-α-induced injury and cell death in concentrations used. Results support medicinal safe use of mushrooms under controlled conditions and cautioned use of higher concentrations.
In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction
Authors: Wu Jingyao , Mady Leila J. , Roy Abhijit , Aral Ali Mübin , Lee Boeun , Zheng Feng , Catalin Toma , Chun Youngjae , Wagner William R. , Yang Ke , Trejo Bittar Humberto E. , Chi David , Kumta Prashant N. 
Published: December 2020

AbstractPediatric laryngotracheal stenosis is a complex congenital or acquired airway injury that may manifest into a potentially life-threatening airway emergency condition. Depending on the severity of obstruction, treatment often requires a combination of endoscopic techniques, open surgical repair, intraluminal stenting, or tracheostomy. A balloon expandable biodegradable airway stent maintaining patency while safely degrading over time may address the complications and morbidity issues of existing treatments providing a less invasive and more effective management technique. Previous studies have focused on implementation of degradable polymeric scaffolds associated with potentially life-threatening pitfalls. The feasibility of an ultra-high ductility magnesium-alloy based biodegradable airway stents was demonstrated for the first time. The stents were highly corrosion resistant under in vitro flow environments, while safely degrading in vivo without affecting growth of the rabbit airway. The metallic matrix and degradation products were well tolerated by the airway tissue without exhibiting any noticeable local or systemic toxicity.
Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
Authors: Staats Roxine , Michaels Thomas C. T. , Flagmeier Patrick , Chia Sean , Horne Robert I. , Habchi Johnny , Linse Sara , Knowles Tuomas P. J. , Dobson Christopher M. , Vendruscolo Michele 
Published: December 2020

AbstractThe aggregation of α-synuclein is a central event in Parkinsons’s disease and related synucleinopathies. Since pharmacologically targeting this process, however, has not yet resulted in approved disease-modifying treatments, there is an unmet need of developing novel methods of drug discovery. In this context, the use of chemical kinetics has recently enabled accurate quantifications of the microscopic steps leading to the proliferation of protein misfolded oligomers. As these species are highly neurotoxic, effective therapeutic strategies may be aimed at reducing their numbers. Here, we exploit this quantitative approach to develop a screening strategy that uses the reactive flux toward α-synuclein oligomers as a selection parameter. Using this approach, we evaluate the efficacy of a library of flavone derivatives, identifying apigenin as a compound that simultaneously delays and reduces the formation of α-synuclein oligomers. These results demonstrate a compound selection strategy based on the inhibition of the formation of α-synuclein oligomers, which may be key in identifying small molecules in drug discovery pipelines for diseases associated with α-synuclein aggregation.
Sideband-resolved resonator electromechanics based on a nonlinear Josephson inductance probed on the single-photon level
Authors: Schmidt Philip , T. Amawi Mohammad , Pogorzalek Stefan , Deppe Frank , Marx Achim , Gross Rudolf , Huebl Hans 
Published: December 2020

AbstractLight-matter interaction in optomechanical systems is the foundation for ultra-sensitive detection schemes as well as the generation of phononic and photonic quantum states. Electromechanical systems realize this optomechanical interaction in the microwave regime. In this context, capacitive coupling arrangements demonstrated interaction rates of up to 280 Hz. Complementary, early proposals and experiments suggest that inductive coupling schemes are tunable and have the potential to reach the single-photon strong-coupling regime. Here, we follow the latter approach by integrating a partly suspended superconducting quantum interference device (SQUID) into a microwave resonator. The mechanical displacement translates into a time varying flux in the SQUID loop, thereby providing an inductive electromechanical coupling. We demonstrate a sideband-resolved electromechanical system with a tunable vacuum coupling rate of up to 1.62 kHz, realizing sub-aN Hz−1/2 force sensitivities. The presented inductive coupling scheme shows the high potential of SQUID-based electromechanics for targeting the full wealth of the intrinsically nonlinear optomechanics Hamiltonian.
High responsivity in MoS2 phototransistors based on charge trapping HfO2 dielectrics
Authors: Nur Roda , Tsuchiya Takashi , Toprasertpong Kasidit , Terabe Kazuya , Takagi Shinichi , Takenaka Mitsuru 
Published: December 2020

Abstract2D Transition Metal Dichalcogenides hold a promising potential in future optoelectronic applications due to their high photoresponsivity and tunable band structure for broadband photodetection. In imaging applications, the detection of weak light signals is crucial for creating a better contrast between bright and dark pixels in order to achieve high resolution images. The photogating effect has been previously shown to offer high light sensitivities; however, the key features required to create this as a dominating photoresponse has yet to be discussed. Here, we report high responsivity and high photogain MoS2 phototransistors based on the dual function of HfO2 as a dielectric and charge trapping layer to enhance the photogating effect. As a result, these devices offered a very large responsivity of 1.1 × 106 A W−1, a photogain >109, and a detectivity of 5.6 × 1013 Jones under low light illumination. This work offers a CMOS compatible process and technique to develop highly photosensitive phototransistors for future low-powered imaging applications.
A modified efficiency‐oriented optimal method for three‐phase interleaved LLC resonant converter in plug‐in hybrid electric vehicle battery chargers
Authors: Shen Chaochao , Zhong Hao , Zhang Yang , Xu Mai , Zhang Yining 
Published: December 2020

AbstractThree‐phase interleaved LLC resonant converters are preferably employed to realize high efficiency and high power density in the application of On‐board Charger. The parameter design of LLC resonant converter with wide range output has always been rigorous and difficult. Compared with the common time‐domain model, a high‐accuracy time domain analysis is adopted to analyze the interaction between three phases in detail. This method improves the accuracy of the design results by adding the interaction analysis. According to the operation mode analysis, transformer's turn ratio, resonant inductor, magnetic inductor and resonant capacitor are optimized based on the design principle of minimizing the conduction loss. Finally, the modified efficiency‐oriented optimal method of wide output range LLC resonant converter is proposed and its design results is validated by a 6.6 kW prototype. The efficiency of the design using proposed method is significantly improved than the results of the common time‐domain model.
Pattern‐reconfigurable dual‐band dipole antenna array with four switchable beams for full coverage in horizontal plane
Authors: Su Chang‐Wei , Jin Huayan , Li Chung‐Yi , Liao Yi‐Jyun , Chin Kuo‐Sheng 
Published: December 2020

AbstractIn this study, we develop a pattern‐reconfigurable dual‐band 1 × 2 dipole antenna array for operation in 2.45‐ and 5.5‐GHz bands. Parasitic directors are added to the antenna to change the shape of the radiation pattern, and the length of parasitic directors are adjusted using diode switches; therefore, each band can switch four beams in 0° (front broadside), 90° (right endfire), 180° (back broadside), and 270° (left endfire) directions to achieve full coverage in the horizontal plane. For demonstration, one prototype of the proposed pattern‐reconfigurable dual‐band dipole antenna array was fabricated and measured. Measured results indicated that dual‐band operation was achieved with the maximum impedance bandwidths of 30.8% and 46% in 2.45‐ and 5.5‐GHz bands, respectively. Four switchable beams were obtained with a maximum gain of 5.3 dBi and a front‐to‐back ratio up to 17.3 dB.
Oligarchic growth in a fully interacting system
Authors: Dencs Z. , Regály Zs. 
Published: December 2020

Context. In the oligarchic growth model, protoplanets develop in the final stage of planet formation via collisions between planetesimals and planetary embryos. The majority of planetesimals are accreted by the embryos, while the remnant planetesimals acquire dynamically excited orbits. The efficiency of planet formation can be defined by the mass ratio between formed protoplanets and the initial mass of the embryo-planetesimal belt.
Aims. In numerical simulations of the oligarchic growth, the gravitational interactions between planetesimals are usually neglected due to computational difficulties. In this way, computations require fewer resources. We investigated the effect of this simplification by modeling the planet formation efficiency in a belt of embryos with self-interacting or non-self-interacting planetesimals.
Methods. We used our own graphics processing unit-based direct N-body integrator for the simulations. We compared 2D models using different initial embryo numbers, different initial planetesimal numbers, and different total initial belt masses. For a limited number of cases, we compared the 2D and 3D simulations.
Results. We found that planet formation efficiency is higher if the planetesimal self-interaction is taken into account in models that contain the commonly used 100 embryos. The observed effect can be explained by the damping of planetesimal eccentricities by their self-gravity. The final numbers of protoplanets are independent of planetesimal self-gravity, while the average mass of the formed protoplanets is larger in the self-interacting models. We also found that the non-self-interacting and self-interacting models qualitatively give the same results above 200 embryos. Our findings show that the higher the initial mass of the embryo-planetesimal belt, the higher the discrepancy between models that use self-interacting or non-self-interacting planetesimals is. The study of 3D models showed quantitatively the same results as the 2D models for low average inclination. We conclude that it is important to include planetesimal self-interaction in both 2D and 3D models in cases where the initial embryo number is less than 200.
Autologe Korrektur einer Förderinsuffizienz 1
Authors: Krönung Gerhard 
Published: December 2020

ZUSAMMENFASSUNGBei einer Y-förmigen Aufzweigung der Shuntvene (z. B. in die Vena cephalica medialis und lateralis am proximalen Unterarm oder in die Vena cephalica und basilica in der Ellenbeuge) mit ausreichender Maturierung beider Shuntschenkel kann bei günstiger Topografie eine autologe Proximalisierung ohne Verlust von Punktionsstrecke erfolgen. Dies ist eine wichtige und biologisch hochwertigere Alternative zum alloplastischen Interponat.
Nichts für Schönwetterkapitäne: CAR-T-Zellen – Immunonkologie trifft Intensivmedizin
Authors: Borrega Jorge Garcia , von Bergwelt-Baildon Michael , Böll Boris 
Published: December 2020

ZUSAMMENFASSUNGWAS IST NEU?CRS und ICANS als Nebenwirkung von CAR-T-Zellen Das Cytokine-Release-Syndrome (CRS) ist die häufigste Nebenwirkung einer CAR-T-Zell-Therapie und kann von leichtem Fieber bis zu einem Multiorganversagen führen. Pathophysiologisch kommt es beim CRS zu einem Zytokinsturm und trotz einer Therapie mit Tocilizumab sind refraktäre und tödliche Verläufe beschrieben. Die Symptome des Immune-Effector-Cell-associated-Neurotoxicity-Syndrome (ICANS) variieren von leichter Desorientiertheit bis zum lebensbedrohlichen Hirnödem. Die Pathophysiologie und Therapie des ICANS sind noch nicht ausreichend erforscht. Die Differenzialdiagnosen von CRS und ICANS sind komplex und umfassen neben Infektionen und Sepsis unter anderem auch eine Toxizität der vorhergehenden Therapie, ein Tumorlysesyndrom und nicht zuletzt einen Progress der Grunderkrankung. Ein klinischer oder laborchemischer Parameter zum sicheren Beweis oder Ausschluss eines CRS oder ICANS gibt es zum heutigen Zeitpunkt nicht.Intensivmedizinische Relevanz und potenzielle Entwicklungen der CAR-T-Zell-Therapie Erste Auswertungen von Real-world-Daten deuten auf eine höhere Rate an schweren Nebenwirkungen im Rahmen der CAR-T-Zell-Therapie als in den Zulassungsstudien hin. Für die Indikation r/r-DLBCL könnten schätzungsweise bis zu maximal 300 Patienten pro Jahr in Deutschland eine intensivmedizinische Betreuung im Rahmen der CAR-T-Zell-Therapie benötigen. Studien mit wesentlich häufigeren soliden Tumoren könnten die Patientenzahl drastisch erhöhen.Therapieziel bei CAR-T-Zell-Patienten und Entscheidungen bei Therapiezieländerung Aufgrund des neuen Therapiekonzepts kann ein Konflikt zwischen bislang palliativem Patientenkollektiv und nun möglicherweise langfristigen Remissionen entstehen. Eine frühzeitige Aufklärung über potenziell lebensbedrohliche Nebenwirkungen im Rahmen der Therapie und eine interdisziplinäre Besprechung der Therapieziele mit den Patienten ist entscheidend.