bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Therefore I Have Removed the Veil”: Disclosure of Secrets in Eleventh-Century Islam and the Literary Character of Maimonides’s Guide
Authors: Michaelis Omer 
Published: June 2020

AbstractThis article investigates Maimonides’s ethos of disclosing “secrets” and explores its Islamic origins, focusing on sources neglected by earlier scholarship concerning the Guide of the Perplexed. I turn from the prevalent method by which the Guide has been studied for decades, namely, as a work at the core of which lie strategies and an ethos of concealment. In lieu of the conventional method, I go in a very different direction by inquiring into the modes that Maimonides used in fashioning his Guide as a work that involves a self-proclaimed exceptional act of revelation of secrets and a breach of the boundaries of concealment. The resulting textual investigation demonstrates that clusters of motifs presented in these sources, as well as structures of arguments, were retained in their cultural migration. This exploration allows me to illuminate new aspects of the question of the genre of Maimonides’ Guide, its sources, and its author’s intertextual art of writing.
Endocrine disruption and altered sexual development in aquatic organisms: an invertebrate perspective
Authors: Langston W. J. 
Published: June 2020

AbstractContaminants causing sex-altering, endocrine disrupting-like (ED) effects, or otherwise influencing reproduction, have been of growing concern to humans for more than 50 years. They have also been a perturbing, though less well-studied, phenomenon in marine organisms, following the recognition of tributyltin (TBT)-induced imposex and population extinctions in (neo)gastropods in the 1970s. Whilst ED impacts in mammals and fish are characterized by mimicry or antagonism of endogenous hormones by environmental contaminants (acting through Nuclear Receptors which are present in all metazoans) much less is known regarding pathways to effects in invertebrates. Despite the absence of a defined steroidal/mechanistic component, the extent, severity and widespread nature of ED-like manifestations and altered sexual characteristics observed in marine invertebrates gives rise to comparable concerns, and have been a long-term component of the MBA's research remit. The manifestations seen in sensitive taxa such as molluscs and crustaceans confirm they are valuable indicators of environmental quality, and should be exploited in this capacity whilst we seek to understand the pervasiveness and underlying mechanisms. In so doing, invertebrate indicators address aims of organizations, such as the EEA, OECD, UNEP and WHO, charged with management and monitoring of chemicals and ensuring that adverse effects on humans and the environment are minimized (Bergman et al., 2013). In view of the recent general declines in marine biodiversity, and the potential contribution of ED-like phenomena, safeguarding against deleterious effects through increased research which links pollutant exposure with reproductive dysfunction among invertebrates, is seen as a high priority.
Constructing families of cospectral regular graphs
Authors: Haythorpe M. , Newcombe A. 
Published: June 2020

AbstractA set of graphs are called cospectral if their adjacency matrices have the same characteristic polynomial. In this paper we introduce a simple method for constructing infinite families of cospectral regular graphs. The construction is valid for special cases of a property introduced by Schwenk. For the case of cubic (3-regular) graphs, computational results are given which show that the construction generates a large proportion of the cubic graphs, which are cospectral with another cubic graph.
Practical guide to climate change for general insurance practitioners
Authors: Rothwell M. , Earle M. , Ooi C. H. , Orr J. , Shroff S. , Siew J. 
Published: June 2020

Abstract
Climate change is one of the biggest challenges facing the world. Scientific research points out that it is predominately driven by human activity. There are three different types of risks that arise from this change. These have been broadly grouped into physical, transition and liability risks. These risks can impact general insurers to different degrees, depending on their business areas and investment strategies. These may pose different strategic, investment, market, operational and reputational risks. This paper provides General Insurance Practitioners with an overview of different aspects of insurance operations that may be affected by climate change. It highlights the impact of these risks on pricing and underwriting, reserving, reinsurance, catastrophe modelling, investment, risk management and capital management processes.
Restricted Chase Termination for Existential Rules: A Hierarchical Approach and Experimentation
Authors: KARIMI ARASH , ZHANG HENG , YOU JIA-HUAI 
Published: June 2020

AbstractThe chase procedure for existential rules is an indispensable tool for several database applications, where its termination guarantees the decidability of these tasks. Most previous studies have focused on the skolem chase variant and its termination analysis. It is known that the restricted chase variant is a more powerful tool in termination analysis provided a database is given. But all-instance termination presents a challenge since the critical database and similar techniques do not work. In this paper, we develop a novel technique to characterize the activeness of all possible cycles of a certain length for the restricted chase, which leads to the formulation of a framework of parameterized classes of the finite restricted chase, called
$k$-$\mathsf{safe}(\Phi)$
rule sets. This approach applies to any class of finite skolem chase identified with a condition of acyclicity. More generally, we show that the approach can be applied to the hierarchy of bounded rule sets previously only defined for the skolem chase. Experiments on a collection of ontologies from the web show the applicability of the proposed methods on real-world ontologies.
Community Integrated Earth System Model (CIESM): Description and Evaluation
Authors: Lin Yanluan , Huang Xiaomeng , Liang Yishuang , Qin Yi , Xu Shiming , Huang Wenyu , Xu Fanghua , Liu Li , Wang Yong , Peng Yiran , Wang Lanning , Xue Wei , Fu Haohuan , Zhang Guang Jun , Wang Bin , Li Ruizhe , Zhang Cheng , Lu Hui , Yang Kun , Luo Yong , Bai Yuqi , Song Zhenya , Wang Minqi , Zhao Wenjie , Zhang Feng , Xu Jingheng , Zhao Xi , Lu Chunsong , Chen Yizhao , Luo Yiqi , Hu Yong , Tang Qiang , Chen Dexun , Yang Guangwen , Gong Peng 
Published: June 2020

AbstractA team effort to develop a Community Integrated Earth System Model (CIESM) was initiated in China in 2012. The model was based on NCAR Community Earth System Model (Version 1.2.1) with several novel developments and modifications aimed to overcome some persistent systematic biases, such as the double Intertropical Convergence Zone problem and underestimated marine boundary layer clouds. Aerosols' direct and indirect effects are prescribed using the MACv2‐SP approach and data sets. The spin‐up of a 500‐year preindustrial simulation and three historical simulations are described and evaluated. Prominent improvements include alleviated double Intertropical Convergence Zone problem, increased marine boundary layer clouds, and better El Niño Southern Oscillation amplitude and periods. One deficiency of the model is the significantly underestimated Arctic and Antarctic sea ice in warm seasons. The historical warming is about 0.55 °C greater than observations toward 2014. CIESM has an equilibrium climate sensitivity of 5.67 K, mainly resulted from increased positive shortwave cloud feedback. Our efforts on porting and redesigning CIESM for the heterogeneous Sunway TaihuLight supercomputer are also introduced, including some ongoing developments toward a future version of the model.
Regulation of phenylpropanoid biosynthesis by MdMYB88 and MdMYB124 contributes to pathogen and drought resistance in apple
Authors: Geng Dali , Shen Xiaoxia , Xie Yinpeng , Yang Yusen , Bian Ruiling , Gao Yuqi , Li Pengmin , Sun Liying , Feng Hao , Ma Fengwang , Guan Qingmei 
Published: June 2020

AbstractMdMYB88 and MdMYB124 have been demonstrated to be responsible for lignin accumulation in apple under drought stress. In this study, using a metabolomic approach, we identified differentially accumulated phenylpropanoid and flavonoid metabolites in MdMYB88/124 transgenic RNAi plants under control and long-term drought stress conditions in apple roots. We confirmed the regulation of phenylalanine by MdMYB88 and MdMYB124 via UPLC-MS in apple roots under both control and drought conditions. Using Electrophoretic Mobility Shift Assay (EMSA) and ChIP-quantitative PCR (qPCR) analyses, we found that MdMYB88 positively regulates the MdCM2 gene, which is responsible for phenylalanine biosynthesis, through binding to its promoter region. Under long-term drought conditions, MdMYB88/124 RNAi plants consistently accumulated increased amounts of H2O2 and MDA, while MdMYB88 and MdMYB124 overexpression plants accumulated decreased amounts of H2O2 and MDA. We also examined the accumulation of metabolites in the phenylpropanoid biosynthesis pathway in the leaves of MdMYB88 and MdMYB124 transgenic apple plants after long-term drought stress. We found that metabolites responsible for plant defense, including phenylpropanoids and flavonoids, accumulated less in the RNAi plants but more in the overexpression plants under both control and drought conditions. We further demonstrated that MdMYB88/124 RNAi plants were more sensitive to Alternaria alternata f. sp. mali and Valsa mali, two pathogens that currently severely threaten apple production. In contrast, MdMYB88 and MdMYB124 overexpression plants were more tolerant to these pathogens. The cumulative results of this study provided evidence for secondary metabolite regulation by MdMYB88 and MdMYB124, further explained the molecular roles of MdMYB88 and MdMYB124 in drought resistance, and provided information concerning molecular aspects of their roles in disease resistance.
Supervised learning of gene-regulatory networks based on graph distance profiles of transcriptomics data
Authors: Razaghi-Moghadam Zahra , Nikoloski Zoran 
Published: June 2020

AbstractCharacterisation of gene-regulatory network (GRN) interactions provides a stepping stone to understanding how genes affect cellular phenotypes. Yet, despite advances in profiling technologies, GRN reconstruction from gene expression data remains a pressing problem in systems biology. Here, we devise a supervised learning approach, GRADIS, which utilises support vector machine to reconstruct GRNs based on distance profiles obtained from a graph representation of transcriptomics data. By employing the data from Escherichia coli and Saccharomyces cerevisiae as well as synthetic networks from the DREAM4 and five network inference challenges, we demonstrate that our GRADIS approach outperforms the state-of-the-art supervised and unsupervided approaches. This holds when predictions about target genes for individual transcription factors as well as for the entire network are considered. We employ experimentally verified GRNs from E. coli and S. cerevisiae to validate the predictions and obtain further insights in the performance of the proposed approach. Our GRADIS approach offers the possibility for usage of other network-based representations of large-scale data, and can be readily extended to help the characterisation of other cellular networks, including protein–protein and protein–metabolite interactions.
Historical dataset of administrative units with social-economic attributes for Austrian Silesia 1837–1910
Authors: Ostafin Krzysztof , Kaim Dominik , Siwek Tadeusz , Miklar Anna 
Published: June 2020

AbstractScientists from many disciplines need historical administrative boundaries in order to analyse socio-economic data in space and time. In this paper, we present a set of historical data consisting of administrative unit boundaries and exemplary socio-economic attributes for Austrian Silesia, an historical region located in modern Czechia and Poland. The dataset covers nearly 700 administrative unit boundaries on the level of cadastral or political communes and their subparts and was acquired through manual vectorisation of historical maps (1:28,800) from the period 1837–1841. The local-level units can be easily joined into higher-level divisions such as court or political districts for the period 1837–1910. The data can then be combined with statistical data collected approximately every 10 years for a similar period. Within the quality assessment, the relations between cartographic and census data and their credibility are analysed. The present dataset provides many possibilities for joining a wide range of historical statistical data to better understand various demographic and economic processes based on advanced analyses, e.g., by using GIS.
Relationship between Lipoprotein (a) and cognitive function – Results from the Berlin Aging Study II
Authors: Röhr Franziska , Bucholtz Nina , Toepfer Sarah , Norman Kristina , Spira Dominik , Steinhagen-Thiessen Elisabeth , Lill Christina M. , Bertram Lars , Demuth Ilja , Buchmann Nikolaus , Düzel Sandra 
Published: June 2020

AbstractIt has been suggested that an age-related loss of cognitive function might be driven by atherosclerotic effects associated with altered lipid patterns. However, the relationship between Lipoprotein (a) [Lp(a)] and healthy cognitive aging has not yet been sufficiently investigated. For the current analysis we used the cross-sectional data of 1,380 Berlin Aging Study II (BASE-II) participants aged 60 years and older (52.2% women, mean age 68 ± 4 years). We employed the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD)-Plus test battery to establish latent factors representing continuous measures of domain specific cognitive functions. Regression models adjusted forAPOEgenotypes, lipid parameters and other risk factors for cognitive impairment were applied to assess the association between Lp(a) and performance in specific cognitive domains. Men within the lowest Lp(a)-quintile showed better cognitive performance in the cognitive domain executive functions and processing speed (p = 0.027). No significant results were observed in women. The results of the current analysis of predominantly healthy BASE-II participants point towards an association between low Lp(a) concentrations and better cognitive performance. However, evidence for this relationship resulting from the current analysis and the employment of a differentiated cognitive assessment is rather weak.
DOE for the formation of the effect of switching between two images when an element is turned by 180 degrees
Authors: Goncharsky Anton , Durlevich Svyatoslav 
Published: June 2020

AbstractAn optical security element forming different 2D images when it is turned by 180 degrees is developed and manufactured for the first time. A synthesis technology is developed that incorporates the computation of the beam pattern in elementary hogels with sizes smaller than 100 microns, computation of the phase function of the diffractive optical element (DOE), and formation of the microrelief of the DOE using electron-beam technology. The DOE employed is a multilevel kinoform with an asymmetrical microrelief shaped with a precision of 10 nm. The resulting security feature is easy to control visually, and the DOE is securely protected against counterfeiting. These DOEs are easy to replicate using standard technologies in the manufacturing of embossed holograms and can be used to protect bank notes, securities, and documents against counterfeiting.
An artificial neural network approach for predicting hypertension using NHANES data
Authors: López-Martínez Fernando , Núñez-Valdez Edward Rolando , Crespo Rubén González , García-Díaz Vicente 
Published: June 2020

AbstractThis paper focus on a neural network classification model to estimate the association among gender, race, BMI, age, smoking, kidney disease and diabetes in hypertensive patients. It also shows that artificial neural network techniques applied to large clinical data sets may provide a meaningful data-driven approach to categorize patients for population health management, and support in the control and detection of hypertensive patients, which is part of the critical factors for diseases of the heart. Data was obtained from the National Health and Nutrition Examination Survey from 2007 to 2016. This paper utilized an imbalanced data set of 24,434 with (69.71%) non-hypertensive patients, and (30.29%) hypertensive patients. The results indicate a sensitivity of 40%, a specificity of 87%, precision of 57.8% and a measured AUC of 0.77 (95% CI [75.01–79.01]). This paper showed results that are to some degree more effectively than a previous study performed by the authors using a statistical model with similar input features that presents a calculated AUC of 0.73. This classification model can be used as an inference agent to assist the professionals in diseases of the heart field, and can be implemented in applications to assist population health management programs in identifying patients with high risk of developing hypertension.
Effect of intramolecular hydrogen-bond formation on the molecular conformation of amino acids
Authors: Giubertoni Giulia , Sofronov Oleksandr O. , Bakker Huib J. 
Published: June 2020

AbstractThe molecular conformation of the carboxyl group can be crucial for its chemical properties and intermolecular interactions, especially in complex molecular environments such as polypeptides. Here, we study the conformational behaviour of the model amino acid N-acetylproline in solution at room temperature with two-dimensional infrared spectroscopy. We find that the carboxyl group of N-acetylproline adopts two distinct conformations, syn- and anti-. In the syn-conformer the O–H group is oriented at ~60∘ with respect to the C=O and in the anti-conformer the O–H is anti-parallel to the C=O. In hydrogen-bond accepting solvents such as dimethyl sulfoxide or water, we observe that, similar to simple carboxylic acids, around 20% of the -COOH groups adopt an anti-conformation. However, when N-acetylproline is dissolved in a weakly hydrogen-bond accepting solvent (acetonitrile), we observe the formation of a strong intramolecular hydrogen bond between the carboxyl group in the anti-conformation and the amide group, which stabilizes the anti-conformer, increasing its relative abundance to ~60%.
Die Fachklinik Bad Bentheim
Authors: Meurer J. , Tsianakas A. 
Published: June 2020

ZusammenfassungDie Fachklinik Bad Bentheim mit ihrer mehr als 300-jährigen Geschichte basierte ursprünglich auf den natürlichen Heilquellen wie dem Schwefelmineralwasser und der Sole. Durch die Entwicklung der Balneofototherapie in den 70er- und 80er-Jahren entwickelte sich die Dermatologie zu einem besonders wichtigen Fachbereich. Heute stellt die Dermatologie mit der Akutklinik, der Klinik für Rehabilitation sowie der Ambulanz und Studienambulanz einen führenden Teilbereich der Klinik dar und bietet ihren Patienten modernste Medizin in historischem Ambiente. Dabei zeigen bspw. der Aufbau einer professionellen Studienambulanz, die Entwicklung eines spezifischen Rehabilitationskonzeptes für chronischen Pruritus sowie der Aufbau der dermato-onkologischen Rehabilitation die Anpassungsfähigkeit an die Erfordernisse der Zeit.
Impfmanagement in der dermatologischen Praxis
Authors: Pierchalla P. 
Published: June 2020

ZusammenfassungDermatologen, die Systemtherapeutika mit immunsuppressiver Wirkung bei chronisch-entzündlichen Dermatosen (z. B. Biologika) in der Praxis verordnen, sollten ein Impfmanagement einführen, um bei der Durchführung notwendiger Impfungen zeitliche Verzögerungen und Probleme bei der Abstimmung mit anderen Fachgruppen zu vermeiden. Auch bei der Betreuung dermatologischer Patienten ohne Immunsuppression kann das Anbieten von Impfungen in der Praxis aus medizinischen und wirtschaftlichen Gründen sinnvoll sein.
Nichterkennung einer Skabies trotz positiver Familienanamnese
Authors: Elsner P. , Meyer J. 
Published: June 2020

ZusammenfassungBei einer Patientin wurde von einem Dermatologen trotz mehrfacher Konsultationen eine Skabies nicht diagnostiziert, obgleich die Tochter der Patientin von eben diesem Dermatologen zeitnah unter der Diagnose einer Skabies behandelt worden war. Erst nachdem die Patientin mit verschlechtertem Hautzustand in einer Hautklinik stationär aufgenommen wurde, erfolgte die korrekte Diagnosestellung und Therapie. Die Schlichtungsstelle bewertete die Nichtberücksichtigung der positiven Familienanamnese für Skabies als vorwerfbaren Diagnosefehler.Bei pruriginösen Erkrankungen unklarer Genese sollte stets auch an eine Skabies gedacht und eine Familienanamnese erhoben werden. Falls diese positiv ist, sind die Familienangehörigen als Kontaktpersonen, d. h. Personen mit längerem Kontakt zu Patienten mit gewöhnlicher Skabies oder Personen auch mit nur kurzem Kontakt zu Patienten mit Scabies crustosa, zu behandeln. Diese erhalten zumindest eine einmalige Sicherheitsbehandlung mit Permethrin, dem aktuellen Behandlungsstandard.
Covid-19: Eine Ad hoc Public-Health-Ethikberatung
Authors: Wild Verina , Buyx Alena , Hurst Samia , Munthe Christian , Rid Annette , Schröder-Bäck Peter , Strech Daniel , Thompson Alison 
Published: June 2020

ZusammenfassungIn diesem Dokument beschreiben wir den Prozess und den Inhalt einer ad hoc
Public-Health-Ethikberatung vom 22. März 2020 für eine
regionale Gesundheitsbehörde (Bayerisches Landesamt für
Gesundheit und Lebensmittelsicherheit) zu Entscheidungen im Zusammenhang mit
Covid-19.
Digital Measurement of Individual Motor and Proprioceptive Skills in Patients with Osteoarthritis of the Knee Prior to Total Knee Replacement
Authors: Redelbach Robert , Mahnke Alexander , Anders Jens O. 
Published: June 2020

Abstract
Purpose In spite of consistent improvement in operative methods for total knee arthroplasty, individual motor deficits may lead to a lower outcome. The preoperative classification in individual motoric capacity may get more significance for the future. Complementary to established questionnaires and clinical tests, this pilot study should demonstrate that it is possible to generate a preoperative motor score using a force platform measurement (KMP). Compared to questionnaires the new score represents digital values suitable for everyday clinical use.
Methods In total 63 Patients were randomized selected on the day before a bicondylar total knee replacement. A mobile force platform KMP (Motosana) measured the parameter maximum force, power and balance. Fluctuation area was measured in mm² and fluctuation path in mm. One leg standing without holding, transient help or permanent holding at armrests were registered. The force (Newton) was measured while a modified cross lift exercise and power (Watt) by performing five squads.
Results Based on comprehensive statistical consolidated data of maximum force, power and balance it was possible to create a new motor score “Knie Fit 1.0”. Depending on interindividual performance patients were divided into those with higher or lower results. Regarding to their individual motor proprioceptive capacity we could also graduate patients into 4 different groups for force/power and balance. In total 17 of 63 patients offered a complex motor deficit, but on the other hand 17 different patients showed superior results in all categories.
Conclusion It is possible to measure the motor capacity of patients using the mobile force platform (KMP) in everyday clinical practice. Based on this data a new motor score “KnieFit 1.0” was generated and groups of patients with different insufficiencies were created. Further follow-up studies should proof and compare the pre- and postoperative outcome in this field. With “KnieFit 1.0” it may be possible to create an individual perioperative rehabilitation program for compensation of detected deficits.