bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using the Minor Variant Finder software to identify and quantify the allelic burden level of somatic mutations in oncohematologic diseases
Authors: Subbotina T. N. , Maslyukova I. E. , Faleeva A. A. , Nikolaeva P. A. , Khazieva A. S. , Dunaeva E. A. , Mironov K. O. , Polushkina L. B. , Martynkevich I. S. , Vereshchagina S. V. , Barankin B. V. 
Published: July 2020

Background. There are problems related to both quantitative assessment of an allele burden level of a mutant gene and interpretation of results in DNA samples with the burden level of the mutant allele less than 15–20 %, when using Sanger sequencing for analyzing somatic mutations. Applied Biosystems (USA) has developed new software Minor Variant Finder, which allows determining mutations with the allele burden level from 5 %.The objective: to determine the allele burden level and identification of minor variants of somatic mutations in the ASXL1, JAK2 genes and BCR-ABL oncogene using Minor Variant Finder software in patients with myeloproliferative neoplasms.Materials and methods. The level of mutant allele burden for 15 patients with myeloproliferative neoplasms was determined by the identified mutations using the Minor Variant Finder software, after analysis of point somatic mutations in the ASXL1, JAK2 genes and BCR-ABL oncogene by Sanger sequencing.Results. The allele burden level in all 5 ASXL1-positive samples and BCR-ABL-positive sample was determined as higher than 20 % using the Minor Variant Finder software. The allele burden level in 2 cases was higher than 20 % and in 7 cases lower than 20 %, when we analyzed 9 JAK2-positive samples.Conclusion. Minor Variant Finder software can be used to estimate the allele burden level and to identify minor variants of somatic mutations in the ASXL, JAK2 and BCR-ABL genes.
Videorresenhas em ambiente digital
Authors: Britto Flávia Thaís Alves , Da Silva Williany Miranda 
Published: July 2020

RESUMO: As diversificadas formas de interatividade conferidas às redes sociais no ambiente digital têm proporcionado a proliferação de uma variedade de textos cada vez mais híbridos em suas semioses. Muitos deles fruto de uma nova roupagem que os gêneros assumem com novas estruturas e funções, dando origem a novos gêneros. Haja vista esse contexto, o presente estudo tem por objeto de investigação a videorresenha, gênero que se assemelha à resenha, porém apresenta características multimodais que modificam seus aspectos estruturais e funcionais. Assim, objetivamos reconhecer o gênero videorresenha, identificando-o a partir de uma descrição estrutural e funcional em canais do YouTube.PALAVRAS-CHAVE: videorresenha; ambiente Digital; YouTube. ABSTRACT: The diverse forms of interaction granted to the social networks in the digital environment have provided a spread of a variety of increasingly hybrid texts in their semioses. Many of them result from a new guise that the genres assume with new structures and functions giving rise to new genres. Considering this context, this study has as its investigation object the video review, a genre that resembles the review, but contains multimodal characteristics that modify its structural and functional aspects. Thus, we aim at recognizing the video review genre, identifying it from a structural and functional description, especially on YouTube channels.KEYWORDS: video review; digital environment; YouTube.
Análisis de la implementación de un programa educativo basado en la metodología mobile learning
Authors: Romero Oliva Manuel Francisco , Jiménez Fernández Rafael , Heredia Ponce Hugo 
Published: July 2020

RESUMEN:Este estudio analiza la repercusión de la metodología m-learning en los procesos de nivelación de la competencia gramatical entre estudiantes universitarios. El diseño cuasi experimental se llevó a cabo con una muestra de 128 estudiantes del Grado en Educación Primaria de la Universidad de Cádiz, distribuidos en grupo control (64 estudiantes) y experimental (64 estudiantes). El desarrollo del experimento se centró en el uso de una aplicación móvil durante siete semanas en las que se desarrollaron diversos foros virtuales para conocer la opinión de los estudiantes. La idoneidad de la aplicación se contrastó mediante un cuestionario de Technology Acceptance Model (TAM), que evidenció un alto índice de eficacia. Los resultados muestran una diferencia significativa en el proceso pretest-postest tanto entre grupos como intragrupo experimental. El estudio concluye con una matriz DAFO que sirve de referencia para una posible réplica de la implementación del programa en otros contextos.
PALABRAS CLAVE: m-learning; dispositivos móviles; competencia gramatical; formación inicial.

ABSTRACT: This study analyzes the repercussion of the m-learning methodology in the process of levelling the grammatical competence among the university students. The quasi-experimental design was carried out with a sample of 128 students of the Primary Education Degree from the University of Cádiz. These students were laid out in two groups: the first group was a control group (64 students) and the second was an experimental one (64 students). The development of the experiment was focused on the use of a mobile device application and it lasted seven weeks, in which various virtual forums emerged in order to know the opinion of the students. The suitability of the application was checked out using a Technology Acceptance Model (TAM) questionnaire, which showed a high efficiency index. The results reveal a significant difference between the pretest and the posttest process, both in the groups and in the experimental intragroup. The study concludes with a SWOT matrix that might be a support, as a reference, for a possible replication of the program's implementation in other contexts.
KEYWORDS: m-learning; mobile devices; grammatical competence; initial training.
O Ato de Avaliar na Educação Infantil: Divergências Conceituais Entre as Avaliações Classificatória e Diagnóstica
Authors: Da Silva Gisele Reinaldo , Freire Paula Cristina Teixeira 
Published: July 2020

Este artigo tem como proposta comparar as avaliações Classificatória e Diagnóstica no que se refere à adequabilidade de sua aplicação no âmbito da educação infantil. Objetiva-se, neste estudo, compreender como a avaliação Diagnóstica contribui na construção da aprendizagem da criança, ao analisar seus estágios de aquisição de conhecimentos de maneira significativa, à medida que identifica potencialidades e dificuldades do educando antes e durante cada fase de ensino. Em contrapartida, defende-se, neste estudo, a inadequabilidade da adoção da avaliação Classificatória na educação infantil, em sua proposta de classificar indivíduos conforme critérios padronizados e previamente estabelecidos, gerando hierarquização entre os educandos, avaliados de maneira pontual e quantitativa, através de graus e notas. Promove-se, assim, uma revisão bibliográfica qualitativa acerca de concepções teórico-críticas comparativas entre as distintas formas de avaliar, a partir da qual se conclui que o ato de avaliar não é um ato neutro que se encerra na confirmação, mas, sim, um ato construtivo, amoroso, inclusivo e dialógico, distintos dos exames classificatórios, que são excludentes. Desta forma, esta pesquisa destaca-se por contribuir para o desenvolvimento da criança como ser social, através do fomento de suas habilidades afetiva, emocional e cognitiva, propiciado pela interação e aprendizagem com o meio em que vive.

Palavras-chave: Formas de Avaliação. Primeira Infância. Avaliação Somativa. Avaliação Analítica.

Abstract
This article aims to compare Classificatory and Diagnostic evaluation concerning the applicability in the environment of early childhood education. It seeks to understand how the Diagnostic evaluation contributes to the child learning process, by analyzing the stages of knowledge acquisition in a significant way, as it identifies learners’ potentialities and difficulties before and during each educational phase. In contrast, this study defends the inadequacy of adopting the Classificatory evaluation at early childhood education, in its proposal of classifying individuals according to standardized and previously established criteria, creating a hierarchy among students, assessed in a punctual and quantitative way, through grades. Thus, a qualitative bibliographic review about comparative theoretical-critical conceptions between the different ways of evaluating is promoted, from which we conclude that the act of evaluating is not a neutral act that ends in the confirmation, but a constructive, loving, inclusive and dialogical act, discrete from the classificatory examination that is exclusionary. Thus, this research stands out for contributing to child development as a social being, through encouraging their affective, emotional and cognitive skills, promoted by the interaction and learning in the environment they live.

Keywords: Assessment Methods. Early Childhood. Somative Evaluation. Analytic Evaluation.
Procesos de innovación gerencial en instituciones hospitalarias de La Guajira – Colombia
Authors: Curiel Correa Mirle Irina 
Published: July 2020

La innovación en los procesos gerenciales representa un factor determinante en las organizaciones e implica conocimiento, manejo de las necesidades y expectativas del personal, por esta razón los gerentes han emprendido esfuerzos dirigidos a fortalecerlos, lo cual debe partir de la conveniencia de tener un propósito empresarial claro, digno y compartido por todos. Por lo cual, analizar los aspectos relacionados con los tipos de innovación: innovación de procesos e innovación de naturaleza funcional permitió determinar las prácticas en innovación y modernización tecnológica en las instituciones hospitalarias de La Guajira-Colombia. Se define metodológicamente una investigación de tipo descriptivo, diseño no experimental de tipo transeccional . Los hallazgos permitieron evidenciar que el desarrollo de los procesos de I + D con aplicaciones gerenciales son escasos, sin embargo, prevalece un esfuerzo desde estas instituciones por involucrase más en los diferentes tipos de innovación, que les permita introducir cambios dirigidos a incrementar la funcionalidad y las prestaciones de la empresa para construir una base permanente de progreso.
Determining optimal risk assessment model in construction projects (Case study: steel plant construction project
Authors: Salajegheh S , Akhavan A , Hajihosseini A 
Published: July 2020

Introduction: Identifying occupational hazards and managing occupational safety and health risks has been the most important mission and responsibility of the health and safety management system in organizations and adopting coded plans to achieve this is the key to continuously improving this system and promoting it. The aim of the present study was to determine the optimal risk assessment methodology in development projects.
Materials and Methods: This was a descriptive-analytic research In this research, using previous research studies and collecting expert opinions, the most important criteria for selecting a specific risk assessment methodology, and then using one of the three most-used techniques is an important activity in the steel making industry and risk assessment. Then, the decision matrix is based on the strengths and weaknesses of the models. The prioritization of these three methods is done using the hierarchical analysis decision method.
Results: In this paper, five key factors, the degree of application in identifying hazards, usability in different stages of risk assessment, reliability, ease of use, and training needs and costs, are identified as the most important criteria for choosing a risk assessment technique and the FMEA method was considered as the best Risk Assessment Method.
Conclusion: FMEA methodhas been introduced with regard to its capabilities as an optimal risk assessment method for contruction projects.
Survey the level of well-being and Psychometric characteristics of hospital nurses’ well-being at work scale
Authors: Soltani Shal R , Saadatbin Javaheri F , Zebardast A 
Published: July 2020

Introduction: Mental health problems is common among nurses, because they have to deal with to workplace stresses such as work-rest cycle problems, overload responsibility, financial problems, lack of vacation time, pressures of work, patient communication frameworks and painful experiences of patients. These factors can decrease their wellbeing, but there is not brief and practical scale to assess psychological resiliency among nurses. Therefore, the aim of the present study was to evaluate the psychometric properties of the hospital nurses’ well-being at work scale.
Materials and Methods: This cross-sectional study was conducted on 194 nurses. The hospital nurses’ well-being at work was administered. The hospital nurses’ well-being at work is composed of 67 items and psychometric properties were examined through the Face validity, Content Validity, Concurrent validity, Construct validity. The data were analyzes by SPSS software.
Results: Face and content validity were approved by five psychologists. The KMO index and Bartlett's Cruity Index indicated that correlation matrix was suitable for performing exploratory factor analysis. Factor analysis with Principal Component Analysis extracted one factor with 67.06% total variance. Internal consistency was confirmed by a Cronbach’s alpha of 0.957. According to the findings of the present study, 2.1% of nurses experienced very low well-being, 6.7% experienced low, 66.6% experienced moderate and 22.7% experienced high one.
Conclusion: This study showed that the hospital nurses’ well-being at workplace had appropriate psychometric properties and is a valid and reliable screening index to measure well-being of nurses. This index could facilitate the assessing Well-Being in brief and practical way among nurses.
Short-term media effects include the alterations of sensitivity towards the real violence from the past
Authors: Tukaiev Sergii , Havrylets Yurii , Rizun Volodymyr , Grimm JuÌˆrgen , Enzminger Andreas , Zyma Igor , Makarchuk Mykola 
Published: July 2020

The purpose of this study was to identify the impact of TV news on the perception and processing of emotional footage of a historical documentary. We noted that the emotional frames taken from TV news stories are relatively weak emotional stimuli compared to the emotional frames of historical documentary. The subjects exposed to the pre-stimulus evaluated the Holocaust pictures as more unpleasant and more activating than those not exposed it. The event-related potentials (ERP) recorded during the presentation of the negative (historical) images had various amplitudes of oscillations due to the preliminary affective impact of TV news footage. The amplitude of the frontal ERP component that related to the decision-making (P300) was bigger in the group without preliminary exposure to the emotional TV news frames due to the reduced sensitivity to the content of images. In this case, the historical images attracted less attention and demanded less emotional effort for emotional evaluation of visual information, analysis, retrieval of information from memory and semantic processes, namely searching for the meaning of the pictures (occipital P300 and the late positive potential). Short-term media effects include alterations of sensitivity towards the emotional content of visual information.

Keywords: Emotion; violence; Holocaust TV news;
PENGARUH MODEL PEMBELAJARAN PROJECT BASED LEARNING TERHADAP KREATIFITAS BERPIKIR DAN LITERASI SAINS SISWA SMAN 1 GERUNG TAHUN 2018/2019
Authors: Raehanah Raehanah , Khatimah Husnul , Suhirman Suhirman 
Published: July 2020

Penelitian ini bertujuan untk mengetahui pengaruh model pembelajaran project based learning terhadap kreatifitas berpikir dan literasi sains siswa SMAN 1 Gerung Tahun 2018/2019 pada materi koloid. Penelitian ini merupakan penelitian quasi-eksperimen,dengan desain pretest-postest group kontrol. Pengambilan sampel menggunakan teknik sampling jenuh dengan jumlah sampel 67 orang. Data kreatifitas berpikir diambil dengan tes pilihan ganda beralasan, dan data literasi sains diambil dengan tes pilihan ganda biasa. Uji hipotesis menggunakan MANOVA. Berdasarkan hasil analisis, kesimpulan sebagai berikut; 1) Ada pengaruh yang signifikan model pembelajaran project based learning terhadap literasi sains secara multivariat (sig=0,022<0,05); 2) Ada pengaruh yang signifikan model pembelajaran project based learning terhadap kreativitas berpikir dan literasi sains (sig=0,033<0,05); 3) Ada pengaruh yang signifikan model pembelajaran project based learning terhadap literasi sains (sig=0,047<0,05).
PENGARUH VARIASI KONSENTRASI JAGUNG TERHADAP KUALITAS NATA DE CORN
Authors: Sulistiyana Sulistiyana , Jayadi Edi M. , Hasanah Uswatun 
Published: July 2020

Nata adalah produk kaya serat yang dibuat dari berbagai media dengan persyaratan cukup sumber karbon, nitrogen, pH dan suhu. Jagung kaya akan vitamin A, B, dan E, Thiamin, Niacin, Pantothenic Acid, dan folat. Vitamin dan Niacin mendorong pertumbuhan sel. Panthothenic Acid penting untuk lipid, protein, dan metabolisme karbohidrat dalam tubuh. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi jagung terhadap kualitas nata de corn yaitu; rendemen, ketebalan, dan kadar air. Penelitian ini menggunakan penelitian eksperimen dengan pendekatan kuantitatif. fermentasi dilakukan pada suhu lingkungan selama 13 hariengan variasi konsentrasi 0%, 10%, 20% dan 30%. Penelitian menggunakan pengulangan sebanyak 6 kali. Pada penelitian ini konsentrasi jagung berpengaruh nyata terhadap ketebalan dan kadar air tetapi tidak berpengaruh nyata pada rendemen nata de corn. Konsentrasi optimum pada analisis kualitas nata de corn ini adalah 20% dengan nilai rendemen 86,37%, ketebalan 0,573 cm dan kadar air 84,466%.
KATA KUNCI: Nata De Corn, Acetobacter xylinum, Jagung, Fermentasi
Absorption of Heavy Metal Lead (Pb) by Water Hyacinth (Eichhornia crassipes) and Its Influence to Total Dissolved Solids of Groundwater in Phytoremediation
Authors: Fahruddin Fahruddin 
Published: July 2020

Waste of heavy metal lead (Pb) in waters needs to be addressed through phytoremediation because it is toxic to the environment. The purpose of this study is to determine the effect of water hyacinth (Eichhornia crassipes) ability in water to absorb heavy metal Pb and its effects to total dissolved solids (TDS) of groundwater during the phytoremediation process. Using E. crassipes, groundwater samples and Pb(NO3)2 as a source of Pb, the initial characterization of the two samples was previously carried out. Created four treatments of ground water, i.e.: P1 contains 2 ppm Pb with E. crassipes, P2 contains 4 ppm Pb with E. crassipes, P3 contains 2 ppm Pb without E. crassipes, and P4 contains 4 ppm Pb without E. crassipes. Observation of Pb by method of atomic absorption spectrometry (AAS) and determination of TDS by gravimetric method, each carried out on days 0, 4, 8, and 12. The results show the treatment of 2 ppm Pb, E. crassipes is more effective at absorbing Pb which is 96.0% compared to treatment 4 ppm Pb which is 90.0%. While 2 ppm Pb and 4 ppm Pb as control only 18.5% and 17.5%. Treatment of 2 ppm Pb which uses E. crassipes shows better water quality than concentration TDS 62.55 ppm compared to treatment of 4 ppm Pb with TDS 70.50 ppm while 2 ppm Pb and 4 ppm Pb as a control does not significantly affect to water quality.
ANALISIS KETERSEDIAAN, KETERJANGKAUAN DAN PEMANFAATAN PANGAN DALAM MENDUKUNG TERCAPAINYA KETAHANAN PANGAN MASYARAKAT DI PROVINSI JAWA TENGAH
Authors: Pujiati Sri , Pertiwi Amelia , Silfia Churun Cholina , Ibrahim Dewa Maulana , Nur Hafida Siti Hadiyati 
Published: July 2020

AbstractFood security becomes an aspect that needs to be considered, especially when the population and degradation of agricultural land are increasing. Many variables that affect the measurement of the food security index, and what is often used is the availability, affordability, and utilization of food. This study aims to determine the effect of food availability, affordability, and utilization variables on the food security index. This study uses a correlational design and multiple regression analysis techniques. All regions in Central Java Province were the objects of this study, there are 35 districts/cities. The results from this study showed that the three variables did not significantly influence the increase of the food security index. The result shows that the current food security index has been influenced by other variables. Therefore, the government needs to examine more closely the new variables that affect the food security index in order to develop a strategy to improve the food security index in Central Java Province, especially in the era of the industrial revolution 4.0. Keywords: Food Security Index; Food Affordability; Food Availability; Food Utilization
ANALISIS SEKTOR PROGRESIF DAN KOMODITI BASIS PERTANIAN DI KABUPATEN BOLAANG MONGONDOW, PROVINSI SULAWESI UTARA
Authors: Yunus Siswono Rahmat , Lanuhu Nurdin , Dian Sari Pipi 
Published: July 2020

AbstractThis study aims to: 1) Identify the economic sectors included in the progressive sector in Bolaang Mongondow Regency; 2) Identify agricultural commodities that are commodity-based agriculture in Bolaang Mongondow Regency. This study uses primary data from the Department of Agriculture and Plantation Agency and secondary data in the form of data on Gross Regional Domestic Product (GRDP) of Bolaang Mongondow Regency and North Sulawesi Province in 2013-2017 and agricultural commodity data of Bolaang Mongondow Regency and North Sulawesi Province in 2012-2016. The data was analyzed using the Location Quotient and Shift Share methods. The results of the study concluded that: 1) There are 5 economic sectors which are the base sectors namely the Agriculture, Forestry and Fisheries sector; Mining and Excavation sector; the Electricity and Gas Procurement sector, the Real Estate sector and the Education Services sector. However, only the Mining and Excavation sector has a progressive growth rate and has a competitive advantage. As for the Agriculture sector itself, it has a growth rate that is not progressive and lacks competitive advantage; 2) There are 15 agricultural commodities which are the base commodities in Bolaang Mongondow Regency, namely green beans, soybeans, corn, rice, candlenut, coffee, cocoa, pineapple, mango, mangosteen, spinach, long beans, kale, eggplant and potatoes. As for now the commodities that are the government's main focus are soybeans, corn, rice, cocoa, pineapple and potatoes. Keywords: Progressive Sector; Base Commodity; Location Quotient; Shift Share.
The stratigraphic evolution of a submarine channel: linking seafloor dynamics to depositional products
Authors: Hubbard Stephen M. , Jobe Zane R. , Romans Brian W. , Covault Jacob A. , Sylvester Zoltan , Fildani Andrea 
Published: July 2020

ABSTRACT
We investigate the relationship between the cross-sectional geomorphic expression of a submarine channel as observed on the seafloor and the stratigraphic product of long-lived erosion, bypass, and sediment deposition. Specifically, by reconstructing the time–space evolution of an individual channel fill (i.e., channel element) exposed in outcrop, we establish a genetic link between thick-bedded channel-element-axis sandstone to thinly interbedded channel-element-margin deposits. Although the bounding surface between axis sandstone and margin thin beds is sharply defined, it is composed of a series of geomorphic surface segments of various ages; as such, the composite stratigraphic surface (∼ 17 m relief) was formed from numerous incision events that repeatedly sculpted the conduit. By demonstrating the origin of the stratigraphic surface, we conclude that geomorphic surfaces with 2–7 m of erosional relief were largely responsible for the observed intra-channel-element architecture (and ultimately, the composite 17-m-thick element). The widely documented channel element axis-to-margin architecture is a product of submarine-channel thalweg dynamics, primarily recording interactions between the seafloor and the basal high-concentration layers of channelized turbidity currents.