bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of profiling the peripheral blood T-cell receptor β-chain repertoire in gastric cancer
Authors: LIU YANWEN LIU YANWEN , Guo Nan nan Guo Nan nan , Wu Yi ting Wu Yi ting , Shi Yu hua Shi Yu hua 
Published: April 2020

Abstract
Background: Gastric cancer is the third cause of cancer-related deaths worldwide, and is initially detected and attacked by the immune system through tumor-reactive T cells. The aim of this study was to determine the basic characteristics of the peripheral blood T-cell receptor (TCR) repertoire in patients with gastric cancer. Methods: High throughput sequencing was used to identify hyper-variable rearrangements of complementarity determining region 3 (CDR3) of the TCR β chain to comprehensively profile the TCR repertoire in peripheral blood samples from 6 advanced gastric cancer patients and 3 early gastric cancer controls. Results: The study showed that the TCR repertoire differed substantially between advanced cancer patients and early controls in terms of CDR3 clonotype, diversity and V/J segment usage. Specifically, low diversity reflected a worse immune status and prognosis in advanced gastric cancer. However the diversity of TCR was not significant difference in wild or mutation patients. Conclusion: TCR repertoire analysis served as a useful indicator of disease development and prognosis in gastric cancer and may be utilized to be biomarker for immunotherapy.
The alignment alteration of transverse plane in growing rabbits after patella dislocation
Authors: Niu Jinghui , Qi Qi , Piao Kang , Hao Kuo , Wang Fei 
Published: April 2020

Abstract
Background: Torsional malalignment in transverse plan has been regarded as a risk factor for patella dislocation. But the influence of patella dislocation for torsional alignment development remains unknown. The present study aims to investigate whether the torsion alteration of the hindlimb occur after patella dislocation in growing rabbits. Methods : Thirty rabbits that were 1 months old were included in the study. The left knees of each rabbit (N = 30 knees/group), were underwent patella lateral dislocation operation and defined as the experimental group. The right knees of each rabbit, defined as the control group (N =30 knees/group), did not undergo any surgical procedures. Computed tomography was performed on each knee immediately post-surgery and 5 months post-surgery to measure femoral version and tibial torsion. The angles was analyzed between the experimental group and control group. Results : The femoral version and tibia torsion in the experimental and control group were not significantly different immediately after surgery. However, 5 months after surgery, the femoral version of the experimental group (-5.50±6.13°) was significantly different with that of the experimental group (-10.90±4.74°)( P < 0.05). But the tibia angle in the experimental group (7.17±7.25°) and control group (4.47±6.34°) were not significantly different ( P = 0.144). Conclusion : Patella dislocation can lead to significant change in femoral version in growing rabbits. Thus if adolescents suffer from patella dislocation or instability for a long time in growing period, the torsional malalignment in lower limbs may occur.
Circulating branched-chain amino acid concentrations are associated with skeletal muscle mass and thyroid function in young Japanese men
Authors: Tsunekawa Katsuhiko , Matsumoto Ryutaro , Ushiki Kazumi , Martha Larasati , Shoho Yoshifumi , Yanagawa Yoshimaro , Ishigaki Hirotaka , Yoshida Akihiro , Araki Osamu , Nakajima Kiyomi , Kimura Takao , Murakami Masami 
Published: April 2020

Abstract
Background Few nutritional markers reflect the hypermetabolic state of athletes with high levels of skeletal muscle. Although branched-chain amino acids (BCAA) play crucial roles in protein metabolism in skeletal muscle, the relation between circulating BCAA concentration and skeletal muscle mass has not been fully understood. The aim of this study is to evaluate the association between skeletal muscle mass and serum BCAA to tyrosine ratio (BTR), a convenient indicator of circulating BCAA, in young Japanese men including wrestling athletes with high skeletal muscle mass. Methods The study enrolled 111 young Japanese men: 70 wrestling athletes and 41 controls. None were taking medications or undergoing extreme dietary restriction or an intense exercise regimen. Each participant’s body composition, serum concentrations of albumin and rapid turnover proteins, BTR, and thyroid function were assessed. Results Compared to the controls, the athletes had significantly higher weight-adjusted skeletal muscle mass (SMM) (p < 0.001) and skeletal muscle index (SMI) (p < 0.001), and lower serum albumin concentration (p < 0.001) and BTR (p < 0.001). Kruskal–Wallis tests with Bonferroni multiple comparison tests showed that serum albumin concentration and BTR were significantly lower in the participants with higher SMM and SMI. Spearman's correlation analyses showed that SMM and SMI were inversely correlated with serum albumin concentration (SMM, ρ = −0.315, p = 0.001; SMI, ρ = −0.511, p < 0.001) and BTR (SMM, ρ = −0.424, p < 0.001; SMI, ρ = −0.511, p < 0.001). Serum albumin concentration was positively correlated with BTR (ρ = 0.438, p < 0.001), transthyretin (ρ = 0.281, p = 0.003) and transferrin (ρ = 0.299, p = 0.001), but BTR was not correlated with other nutritional indicators. Serum concentration of free 3,5,3′-triiodothyronine was inversely correlated with BTR (ρ = −0.308, p = 0.001), but not with serum albumin or skeletal muscle mass. Conclusions These results suggest that the consumption of circulating BCAAs increases with increased skeletal muscle mass and is facilitated by thyroid hormones independent of skeletal muscle mass. Serum BTR may be a useful biomarker to assess the hypermetabolic state of athletes.
Remaining useful life prediction based on a modified SVR method with health stage division, cluster sampling and similarity matching
Authors: Yan Jian-wen , Zhong Xiao-hu , Cheng Yu-cheng , Fan Yu 
Published: April 2020

Abstract
Remaining useful life (RUL) prediction is an advanced methodology of prognostics and health management (PHM), and is in advantage of life cycles management of equipment and maintenance cost reduction. Among the data driven methods, support vector regression (SVR) is one of the most suitable methods when there are limited failure history data for analysis. However, many uncertain factors such as individual variation and time varying operating conditions, will lead that the failure time of all equipment statistically dispersive, and with the increase of sample set, such dispersity may inevitably increase and further reflects in the model training. In consequent, the dispersity may cause two drawbacks. On the one hand, the linearity of SVR model will increase with the increase of sample set, and overfitting or underfitting tends to occur. And on the other hand, a single model only performs well in its generalization and robustness, but may lost its effectiveness that it may fail to work well for a new on-service equipment. In order to deal with the two drawbacks, this paper proposes a modified SVR method with health stage division, cluster sampling and similarity matching. Through health stage division and cluster sampling, each state of the whole degradation process can obtain the optimal parameters, then the irrelevant linearity can be reduced. In addition, since that similar input results similar output, the optimal parameters of the most similar testing sample are also suitable for the on-service equipment, and through similarity matching the most similar testing sample can be obtained, thus the drawback of a single model can be avoided. Finally, the effectiveness of the proposed method is verified systematically by a simulated dataset of fatigue crack growth and a real-world degradation dataset of GaAs-based lasers.
Blockchain Leveraged Cyberbullying Preventing framework
Authors: Wadud Md Anawar Hossen , Uddin Md Ashraf , Parvez Shamima , Rahman Mohammad Motiur , Alazab Ammar , Akter Omi 
Published: April 2020

Abstract
The popularity of social media has exploded worldwide over the last few decades and becomes the most preferred mode of social interaction. The internet also provides a new platform through which adolescents are being bullied. Appropriate means of cyberbullying detection is still partial and in some cases very limited. Moreover, research on cyberbullying detection extensively focuses on surveys and its psychological impacts on victims. However, prevention has not been widely addressed. To bridge the gap, this paper aims to detect cyberbullying efficiently. This paper employs a standard machine learning method and natural language processing technique as a part of the detection process in decentralized Blockchain leveraged architecture. We provide a fog based architecture for cyberbullying detection, aiming at relieving the server's load by placing the detection and the prevention of cyberbullying processes at the fog layer. The proposal might offer a probable solution to save users, particularly adolescents from severe consequences of cyberbullying.
Bacillus subtilis from Potato Rhizosphere as Biological Control Agent and Chili Growth Promoter
Authors: Prihatiningsih Nur , Djatmiko Heru Adi , Erminawati Erminawati , Lestari Puji 
Published: April 2020

Bacillus subtilis is an antagonist bacteria that inhibits the growth of fungal and bacterial plant pathogens. The B. subtilis has roles as biocontrol agents and plant growth promoting rhizobacteria (PGPR). This research aimed to evaluate the potency of B. subtilis isolates (B209, B211, and B298) as a biocontrol agent to anthracnose (caused by Colletotrichum spp.) and as PGPR to increase the growth of chili plants. The experiments were divided into two batches. The first batch was conducted in the laboratory to evaluate the characteristics of B. subtilis (as biocontrol) and PGPR (phosphate solubility, producing IAA and nitrogen). The second batch was conducted in the field in Rempoah Village, Baturraden Regency, Banyumas District, with 5 treatments and 6 replications. Parameters observed were inhibition percentage to Colletotrichum spp., disease intensity, the component of PGPR, plant growth of chili, and phatosystem. The results showed that B209, B211, and B298 isolates inhibited the growth of Colletotrichum spp, with the highest inhibition percentage on B298. B209, B211, and B298 have characteristics as PGPR, i.e. the ability to soluble phosphate, to produce IAA and nitrogen. The ability of B298 to promote plant growth was shown by the increase of plant height, leaf number, plant dry mass, and dry root mass (38.0%, 54.7%, 61.7%, 61.8%, respectively). B298 and B211 could increase the fresh crop mass (41.2% and 37.1%) and fresh root mass (36.4% and 34.4%). B298 and B209 were similar in increasing the root length (25.2%). Root volume could be increased by 33.3% by applying B211 isolate. B209 was the best isolate to reduce anthracnose up to 80.36%.
Relationship between Neutrophil to Lymphocyte Ratio with Diaphragm Thickness in Critical Patients
Authors: Haloho Agustina , Sedono Rudyanto , Sugiarto Adhrie , Zulkifli Zulkifli 
Published: April 2020

Abstract

Background: The cause of weaning failure is multifactorial. One of the causes was Ventilator Induced Diaphragm Dysfunction (VIDD) due to thinning process of the diaphragm thickness. Decreased diaphragm muscle mass might occur due to inflammatory process.
Methods: The study was an observational analytic study from September 2018 to January 2019 in Mohammad Hoesin Hospital, Palembang â€“ Indonesia. Ethical appoval for the study was obtained from Ethics Committee and subjects were recruited after signing the informed consents. Only 30 subjects were involved in the end of the study. About 6 mL of blood sample from cubital vein was withdrawn from each subject to measure neutrophils and lymphocytes. Patientsâ€™ diaphragm thickness was measured by using ultrasonography on 0th, 3rd, 5th day. Collected data were then analyzed with STATA 15.
Results: The chi-square test showed that the relationship of NLR (neutophil to lymphocyte ratio) of the 0th day to the decrease in diaphragm thickness on the 3rd day was not significant (p = 0.254), while the decrease in diaphragm thickness on the 5th day was significant (p = 0.015). Subjects with initial NLR values >7 had a significant higher risk of having decreased diaphragm thickness compared to subjects with initial NLR values â€‹â€‹â‰¤7 (RR = 1.62 (0.99-2.64); p-value = 0.003).
Conclusion: Neutrophil to lymphocyte ratio affected the decrease of diaphragm thickness in patients using mechanical ventilation.
EFEKTIVITAS MOBILISASI MIRING KIRI MIRING KANAN DALAM UPAYA PENCEGAHAN PRESSURE INJURY PADA PASIEN SEPSIS DI RUANG INSTALASI PELAYANAN INTENSIF
Authors: Simanjuntak Tiurmauli Rotua , Purnama Agus 
Published: April 2020

Pendahuluan :Â perawat berperan dalam merawat pasien dalam keterkaitan dengan kenyamanan pasien-pasien dengan total bedrest, salah satunya adalah dengan melakukan miring kanan dan kiri..Tujuan :Â untuk memgetahui efektivitas mobilisasi miring kiri miring kanan yang dalam hal ini posisi miring 30 derajat dalam upaya pencegahan pressure injury/luka tekan pada pasien sepsis.Metode:Â Metode yang digunakan Post Test Only Control Group Design dengan jumlah populasi sebanyak 30 responden.Hasil :Â Hasil penelitian menunjukkan bahwa mobilisasi miring kiri miring kanan ada pengaruh dalam pencegahan pressure injury/luka tekan pada pasien sepsis baik itu dengan metode 30 derajat dan 90 derajat (p=0,004 < Î±=0,05).Kesimpulan: Mobilisasi miring kiri miring kanan efektif dalam pencegahan risiko pressure injury/luka tekan pada pasien sepsis.
آراء أبي الحسن الأشعري في مسائل أصول الفقه وأثرها في اختياراته الكلامية
Authors: الميساوي محمد الطاهر , سلهب بلال بركات 
Published: April 2020

تُعنى هذه الدراسة بإبراز جانب مهم من التراث العلمي لأبي الحسن الأشعري (260-324ﻫ/874-936م) لم ينل حظه من البحث، وهو الجانب المتعلِّق بالعلاقة الجدلية التفاعلية عنده بين النظر في مسائل علم أصول الفقه والبحث في قضايا علم الكلام، من أجل الكشف عن أثر آرائه في الأول في توجيه مذاهبه في الثاني. وقد سلكت الدراسة في ذلك منهجاً يقوم على استنطاق نصوص الأشعري نفسه، وعدم التعويل على ما نُسِب إليه في مصنَّفات علماء الأصول والكلام المتأخرين، باستثناء ابن فورك الذي يُعَدُّ كتابه "مقالات الأشعري" مصدراً أولياً لفكر الأشعري بعد مصنَّفات هذا الأخير الثابتة نسبتها إليه. أمّا مناط التركيز في الدراسة فهو مباحث الجانب الأصولي اللغوي كما يتجلّى في تلك المصادر الأولية.
This study is concerned with bringing to light an important, but understudied, aspect of the scholarly legacy of Abu al-Hasan al-Ash‘ari (260-324H/874-936CE), namely the dialectical and interactive relationship between the inquiry of issues of Islamic legal theory and investigation into questions of Islamic theology. The aim is to see how al-Ash‘ari’s views in legal theory shaped his opinions in theology. The study engages itself with al-Ash‘ari’s texts themselves with resorts to what has been attributed to him in the works of later Muslim legal theorists and theologians, to the exception of Ibn Furak’s Maqalat al-Ash‘ari which stands as a primary source next to al-Ash‘ari’s works whose attribution to is beyond doubt. The study has focused on fundamental issues pertaining to legal theory as expounded in those primary sources.
PENINGKATAN MOTIVASI DAN KEMAMPUAN BERPIKIR KRITIS MAHASISWA MELALUI MODEL PEMBELAJARAN BERBASIS MASALAH BERBANTUAN MEDIA EDMODO
Authors: Suparya I Ketut 
Published: April 2020

Tujuan penelitian ini adalah 1) untuk mendeskripsikan peningkatan motivasi mahasiswa melalui model pembelajaran berbasis masalah berbantuan media edmodo, 2) untuk mendeskripsikan peningkatan kemampuan berpikir kritis mahasiswa melalui model pembelajaran berbasis masalah berbantuan media edomodo, 3) untuk mendeskripsikan respon mahasiswa terkait penerapan model pembelajaran berbasis masalah berbantuan media edomodo. Penelitian ini merupakan penelitian tindakan kelas dengan subyek penelitian ini seluruh mahasiswa semester IV program studi Pendidikan Guru Sekolah Dasar STAH Negeri Mpu Kuturan Singaraja sebanyak 20 orang mahasiswa. Obyek penelitian adalah motivasi belajar mahasiswa dan kemampuan berpikir kritis pada pembelajaran IPA SD. Metode analisis dalam penelitian ini adalah deskriptif kualitatif. Adapun hasil dari penelitian ini adalah sebagai berikut: 1) terjadi peningkatkan motivasi belajar mahasiswa dari 66,27% pada siklus I menjadi 82,25% pada siklus II, atau peningkatan sebesar 15,98% berada pada kategori baik, 2) terjadi peningkatan kemampuan berpikir kritis mahasiswa dari 69,50% pada siklus I menjadi 84,40% pada sisklus II atau peningkatan sebesar 15% berada pada kategori baik, 3) persentase rerata respon mahasiswa terhadap proses pembelajaran sebesar 80,10% berada pada kategori baik.
Predicting EdD Applicant Potential Using Structured Behavioral Interviews During the Application Process
Authors: Kimbrel Laurie A. , Varga Mary Alice 
Published: April 2020

This essay describes the work of faculty at a public university in the southeast to align their application process with CPED principles through the addition of structured behavioral interviews. Their work was grounded in the premise that redefinition of the Ed. D. program to focus on the effective preparation of scholarly practitioners also requires a redefinition of the type of student who is most likely to benefit and, consequently, how the applicants most likely to achieve success are identified and admitted. A structured interview was added to the application process as a tool to gather data to accurately predict the likelihood of student success in the program and as a leader of change in schools. The development of the interview was guided by selection science literature, and questions were aligned to essential student attributes. Although the interview questions and process are still evolving, data from the initial administration suggests that the interview has promise as a useful element of the candidate selection process.
La creación del mundo on the Seventeenth-century Street and Stage
Authors: Thacker Jonathan 
Published: April 2020

Abstract
By 1629 there were two comedias entitled La creación del mundo in the repertoires of Golden Age acting troupes, one by Lope de Vega and the other by Luis Vélez de Guevara. From the texts of the plays, one a printed edition and the other a manuscript, and perhaps especially from the stage directions included in these playtexts, it is possible to make some tentative deductions about how and where these works—dramatizing the early chapters of the Old Testament Book of Genesis—were performed. Analysis of archival documentation from Badajoz together with these two playtexts and an awareness of performance norms of the period may help solve the riddle of which Creación came first, Lope’s or Vélez’s.
O ENSINO DO SISTEMA ENDÓCRINO PELA PERSPECTIVA DA APRENDIZAGEM BASEADA EM PROBLEMAS / EDUCATION OF THE ENDOCRINE SYSTEM FROM A PROBLEM-BASED LEARNING PERSPECTIVE
Authors: De Souza Clauberto Medeiros , Rebeca Rosilene 
Published: April 2020

Esta pesquisa apoiou-se na Aprendizagem Baseada em Problemas (ABP) para ensinar a fisiologia do sistema endócrino humano e mediar a aprendizagem significativa. O objetivo primário foi possibilitar o protagonismo do aluno na construção de novos conhecimentos acerca da fisiologia do sistema endócrino por meio de uma sequência didática (SD) que continha um estudo de caso, além de discussões e reflexões intra e intergrupos. Trata-se de uma pesquisa com abordagem qualitativa, de natureza aplicada e interpretativa, abrangendo os acadêmicos do 2º período do Curso de Fisioterapia da Faculdade Guairacá-PR. O diagnóstico dos saberes prévios e a evolução conceitual foram obtidos por meio de questionários semi-estruturados (pré e pós-teste). A comparação do pré e pós-teste demonstrou que os alunos agregaram novos significados aos já existentes e que aqueles que alegavam desconhecimento sobre o tema demonstraram evolução em suas concepções sobre os conceitos chave para a compreensão do tema.
H2‐Directing Strategy on In Situ Synthesis of Co‐MoS2 with Highly Expanded Interlayer for Elegant HER Activity and its Mechanism
Authors: Jin Qiu , Liu Ning , Dai Chengna , Xu Ruinian , Wu Bin , Yu Gangqiang , Chen Biaohua , Du Yanze 
Published: April 2020

AbstractMoS2 has drawn great attention as a promising Pt‐substituting catalyst for the hydrogen evolution reaction (HER). This work utilizes H2 as the structure directing agent (SDA) to in situ synthesize a range of Co‐MoS2‐n (n = 0, 0.5, 1.0, 1.4, 2.0) with expanded interlayer spacings (d = 9.2 – 11.1 Å), which significantly boost their HER activities. The Co‐MoS2‐1.4 with an interlayer spacing of 10.3 Å presents an extremely low overpotential of 56 mV (at 10 mA cm−2) and a Tafel slope of 32 mV dec−1, which is superior than most reported MoS2‐based catalysts. Density function theory calculations are used to gain insights that i) the H2 can be dissociatively adsorbed on MoS2 and greatly affect the related surface free energy by regulating the interlayer spacing; ii) the expanded interlayer spacing can significantly decrease the absolute value of ΔGH, thereby leading to greatly promoted HER activity. Additionally, the large amounts of 1T phase (73.9–79.2%) and Co‐Mo‐S active sites (40.9–91.3%) also contribute to the enhanced HER activity of the synthesized samples. Overall, a simple new strategy for in situ synthesis of Co‐MoS2 with an expanded interlayer spacing is proposed, which sheds light on other 2D energy material designs.
An Efficient Ultra‐Flexible Photo‐Charging System Integrating Organic Photovoltaics and Supercapacitors
Authors: Liu Ruiyuan , Takakuwa Masahito , Li Ailong , Inoue Daishi , Hashizume Daisuke , Yu Kilho , Umezu Shinjiro , Fukuda Kenjiro , Someya Takao 
Published: April 2020

AbstractFlexible and biocompatible integrated photo‐charging devices consisting of photovoltaic cells and energy storage units can provide an independent power supply for next‐generation wearable electronics or biomedical devices. However, current flexible integrated devices exhibit low total energy conversion and storage efficiency and large device thickness, hindering their applicability towards efficient and stable self‐powered systems. Here, a highly efficient and ultra‐thin photo‐charging device with a total efficiency approaching 6% and a thickness below 50 µm is reported, prepared by integrating 3‐µm‐thick organic photovoltaics on 40 µm‐thick carbon nanotube/polymer‐based supercapacitors. This flexible photo‐charging capacitor delivers much higher performance compared with previous reports by tuning the electrochemical properties of the composite electrodes, which reduce the device thickness to 1/8 while improving the total efficiency by 15%. The devices also exhibit a superior operational stability (over 96% efficiency retention after 100 charge/discharge cycles for one week) and mechanical robustness (94.66% efficiency retention after 5000 times bending at a radius of around 2 mm), providing a high‐power and long‐term operational energy source for flexible and wearable electronics.