bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatisierte Berechnung und Visualisierung von Komorbiditätsindizes für den Tumorboard-Entscheid
Authors: Wald Theresa , Birnbaum Klemens , Wiegand Susanne , Dietz Andreas , Zebralla Veit , Wichmann Gunnar 
Published: October 2020

Zusammenfassung
Einleitung Komorbidität beeinflusst die für die kurative Therapie von Kopf-Hals-Karzinomen (HNC) verfügbaren Optionen. Das manuelle Zusammentragen der Nebenerkrankungen vor der Anmeldung im interdisziplinären Tumorboard (TB) ist zeitintensiv und oft unvollständig. Eine automatisierte Erfassung von nach ICD-10 kodierten Komorbiditätsdaten und deren Darstellung könnte die therapeutische Entscheidungsfindung im TB verbessern sowie bestehenden Informationsbedarf aufzeigen.
Material und Methoden Die ICD-10-Codes unserer Patienten wurden aus 4 Datenbanken (hospital-information-system (HIS*-MED), der klinikinternen Tumordatenbank, OncoFlow® und OncoFunction®) extrahiert. Nach der Datensatzverknüpfung mittels der Python-Programmbibliotheken Pandas und Record Linkage wurden die ICD-10-Codes bezüglich des Charlson-Scores gewichtet und für die Implementierung in OncoFlow visualisiert. Die Kodierqualität wurde am Beispiel Diabetes an einer 1:1 gematchten Stichprobe von 240 Patienten überprüft.
Ergebnisse 29 073 ICD-10-Codes von 2087 Patienten mit HNC wurden extrahiert. Die Anmeldung eines Patienten im TB triggert die sofortige automatische Erfassung und Visualisierung der Daten als Piktogramm in OncoFlow. Dies ermöglicht die schnelle Erfassung und Bewertung der Komorbidität sowie erforderlicher Diagnostik zur Komplettierung der Daten. Die klinikinterne Validationsstudie ergab eine Präzision der durch Datenimport verfügbaren Information zu Diabetes von 95,0 %.
Diskussion Patienten mit HNC weisen häufig für die Therapieentscheidung relevante Nebenerkrankungen auf. Die automatisierte Erfassung der Komorbidität aus administrativen Daten und deren intuitive Darstellung ist ressourcen- und kostengünstig möglich. Voraussetzung ist eine präzise, vollständige Verschlüsselung der Krankheitsdiagnosen.
Direct Observational Study of Interfaced Smart-Pumps in Pediatric Intensive Care
Authors: Howlett Moninne M. , Breatnach Cormac V. , Brereton Erika , Cleary Brian J. 
Published: October 2020

Abstract
Background Processes for delivery of high-risk infusions in pediatric intensive care units (PICUs) are complex. Standard concentration infusions (SCIs), smart-pumps, and electronic prescribing are recommended medication error reduction strategies. Implementation rates in Europe lag behind those in the United States. Since 2012, the PICU of an Irish tertiary pediatric hospital has been using a smart-pump SCI library, interfaced with electronic infusion orders (Philips ICCA). The incidence of infusion errors is unknown.
Objectives To determine the frequency, severity, and distribution of smart-pump infusion errors in PICUs.
Methods Programmed infusions were directly observed at the bedside. Parameters were compared against medication orders and autodocumented infusion data. Identified deviations were categorized as medication errors or discrepancies. Error rates (%) were calculated as infusions with errors and errors per opportunities for error (OEs). Predefined definitions, multidisciplinary consensus and grading processes were employed.
Results A total of 1,023 infusions for 175 patients were directly observed over 27 days between February and September 2017. The drug library accommodated 96.5% of infusions. Compliance with the drug library was 98.9%. A total of 133 infusions had ≥1 error (13.0%); a further 58 (5.7%) had ≥1 discrepancy. From a total of 4,997 OEs, 153 errors (3.1%) and 107 discrepancies (2.1%) were observed. Undocumented bolus doses were most commonly identified (n = 81); this was the only deviation in 36.1% (n = 69) of infusions. Programming errors were rare (0.32% OE). Errors were minor, with just one requiring minimal intervention to prevent harm.
Conclusion The error rates identified are low compared with similar studies, highlighting the benefits of smart-pumps and autodocumented infusion data in PICUs. A range of quality improvement opportunities has been identified.
Sphingosine-1-Phosphate Attenuates Lipopolysaccharide-Induced Pericyte Loss via Activation of Rho-A and MRTF-A
Authors: Abdel Rahman Farah , d'Almeida Sascha , Zhang Tina , Asadi Morad , Bozoglu Tarik , Bongiovanni Dario , von Scheidt Moritz , Dietzel Steffen , Schwedhelm Edzard , Hinkel Rabea , Laugwitz Karl Ludwig , Kupatt Christian , Ziegler Tilman 
Published: October 2020

AbstractThe high mortality seen in sepsis is caused by a systemic hypotension in part owing to a drastic increase in vascular permeability accompanied by a loss of pericytes. As has been shown previously, pericyte retention in the perivascular niche during sepsis can enhance the integrity of the vasculature and promote survival via recruitment of adhesion proteins such as VE-cadherin and N-cadherin. Sphingosine-1-phosphate (S1P) represents a lipid mediator regulating the deposition of the crucial adhesion molecule VE-cadherin at sites of interendothelial adherens junctions and of N-cadherin at endothelial–pericyte adherens junctions. Furthermore, in septic patients, S1P plasma levels are decreased and correlate with mortality in an indirectly proportional way. In the present study, we investigated the potential of S1P to ameliorate a lipopolysaccharide-induced septic hypercirculation in mice. Here we establish S1P as an antagonist of pericyte loss, vascular hyperpermeability, and systemic hypotension, resulting in an increased survival in mice. During sepsis S1P preserved VE-cadherin and N-cadherin deposition, mediated by a reduction of Src and cadherin phosphorylation. At least in part, this effect is mediated by a reduction of globular actin and a subsequent increase in nuclear translocation of MRTF-A (myocardin-related transcription factor A). These findings indicate that S1P may counteract pericyte loss and microvessel disassembly during sepsis and additionally emphasize the importance of pericyte–endothelial interactions to stabilize the vasculature.
Video-Assisted Thoracoscopic or Conventional Thoracic Surgery in Infants and Children: Current Evidence
Authors: Kiblawi Rim , Zoeller Christoph , Zanini Andrea , Ure Benno M. , Dingemann Jens , Kuebler Joachim F. , Schukfeh Nagoud 
Published: October 2020

Abstract
Introduction The pros and cons of video-assisted thoracoscopic versus conventional thoracic surgery in infants and children are still under debate. We assessed reported advantages and disadvantages of video-assisted thoracoscopy in pediatric surgical procedures, as well as the evidence level of the available data.
Materials and Methods A systematic literature search was performed to identify manuscripts comparing video-assisted thoracoscopic and the respective conventional thoracic approach in classic operative indications of pediatric surgery. Outcome parameters were analyzed and graded for level of evidence (according to the Oxford Centre of Evidence-Based Medicine).
Results A total of 48 comparative studies reporting on 12,709 patients, 11 meta-analyses, and one pilot randomized controlled trial including 20 patients were identified. More than 15 different types of advantages for video-assisted thoracoscopic surgery were described, mostly with a level of evidence 3b or 3a. Most frequently video-assisted thoracoscopic surgery was associated with shorter hospital stay, shorter postoperative ventilation, and shorter time to chest drain removal. Mortality rate and severe complications did not differ between thoracoscopic and conventional thoracic pediatric surgery, except for congenital diaphragmatic hernia repair with a lower mortality and higher recurrence rate after thoracoscopic repair. The most frequently reported disadvantage for video-assisted thoracoscopic surgery was longer operative time.
Conclusion The available data point toward improved recovery in pediatric video-assisted thoracoscopic surgery despite longer operative times. Further randomized controlled trials are needed to justify the widespread use of video assisted thoracoscopy in pediatric surgery.
Sacrum Ultrasonography: An Accurate Alternative to Radiography for Measuring Sacral Ratio in Infants
Authors: Riahinejad Maryam , Masoumi Mohsen , Farghadani Maryam , Changanian Parvaneh , Hosseinpour Mehrdad 
Published: October 2020

Abstract
Introduction The aim of this study was to compare the compliance of sacrum ultrasonography with radiography for the measuring of sacral ratio in infants.
Materials and Methods A total of 129 infants under the age of 6 months, who were a candidate for abdominal and/or pelvic radiographs, were assessed. Sacrum ultrasonography and radiography were performed by a single radiologist using the same device. The sacral ratio was calculated for all patients undergoing ultrasonography and radiography. Agreement between two methods was calculated by Bland-Altman's chart.
Results The mean of sacral ratio was 0.70 ± 0.11 radiographically and 0.72 ± 0.05 ultrasonographically. Based on Bland-Altman's chart, the mean difference between ultrasonography and radiology was 4.6 mm (confidence intervals of 8.18 ± 5.6).
Conclusion Sacrum ultrasonography could be safely used in the investigation of sacral ratio to detect sacrum abnormalities in infants.
Long-Term Treatment with Apixaban in Patients with Atrial Fibrillation: Outcomes during the Open-Label Extension following AVERROES
Authors: Benz Alexander P. , Eikelboom John W. , Yusuf Salim , Hohnloser Stefan H. , Kahl Anja , Beresh Heather , Balasubramanian Kumar , Healey Jeff S. , Connolly Stuart J. 
Published: October 2020

Abstract
Background AVERROES, a randomized controlled trial in high-risk patients with atrial fibrillation, unsuitable for vitamin K antagonist therapy, demonstrated efficacy and safety of apixaban compared with aspirin. At the conclusion of the double-blind phase, an open-label extension was initiated to allow study participants to receive apixaban until it became locally available. This study reports outcomes of patients on apixaban during the open-label extension.
Methods Rates of stroke or systemic embolism, hemorrhagic stroke, major bleeding, and other outcomes during the open-label extension are reported.
Results Of the 5,599 participants enrolled in AVERROES, 3,275 (58.5%) received apixaban during the open-label extension. Median (interquartile range) follow-up in the open-label extension was 3.0 (2.5–3.5) years. The rate of stroke or systemic embolism during the open-label extension was 1.0% per year, and the annual rates of hemorrhagic stroke and major bleeding were 0.3 and 1.2%, respectively. After adjustment for imbalances in patient variables, event rates in patients on apixaban during the open-label extension were similar to those of patients receiving apixaban during AVERROES. Additional analyses in all patients who received apixaban, at any time from the start of AVERROES to the end of the open-label extension, were performed. This cohort (n = 4,414) showed annual event rates of 1.1% for stroke or systemic embolism, 0.3% for hemorrhagic stroke, and 1.2% for major bleeding.
Conclusion During the open-label extension, annual rates of stroke or systemic embolism, hemorrhagic stroke, and major bleeding remained as low as those observed during apixaban treatment in AVERROES. These data support the long-term efficacy and safety of apixaban in patients with atrial fibrillation.
On first order symmetry operators for the field equations of differential forms
Authors: Michishita Yoji 
Published: October 2020

Abstract
We consider first order symmetry operators for the equations of motion of differential p-form fields in general D-dimensional background geometry of any signature for both massless and massive cases. For p = 1 and p = 2 we give the general forms of the symmetry operators. Then we find a class of symmetry operators for arbitrary p and D, which is naturally suggested by the lower p results.
Rolling cylinder and static friction: model and experiments
Authors: D’Anna Michele , Fuchs Hans U 
Published: October 2020

Abstract
We present an experiment in which we measure the static friction force necessary for a cylinder to roll without slipping on a horizontal surface. Additionally, we introduce an alternative formulation of the rolling condition, based on the observation that the ratio between angular and linear momentum of an object rolling without slipping is independent of particulars of its motion. Since the same holds also for their rates of change, from the basic laws of dynamics, we derive a natural relation between forces and torques allowing for a physical interpretation of the dynamic behavior of the cylinder as well as determination of the value of the static friction force.
Assay of direct digital output floating-wiper resistive displacement sensor
Authors: Mohan Aparna , Mohanasankar S , Jagadeesh Kumar V 
Published: October 2020

Abstract
The principle of operation of a successive approximation type direct displacement to digital converter for a floating-wiper resistive potentiometric sensor, presented earlier, is analyzed in detail to ascertain possible sources of error that can affect the performance of the transducer. Based on the analysis the method is suitably modified to improve its performance. To establish the efficacy of the altered scheme, a prototype signal conditioning circuit has been built and tested using both an emulated sensor and a prototype sensor. While the worst-case error in the former was found to be 0.5%, it was less than 0.8% in the latter. The test results indicate that the digital output is directly proportional to the per-unit displacement and is independent of the value of the coupling capacitance between the floating-wiper and the resistive element.
Two-dimensional beam emission spectroscopy for hydrogen isotope negative neutral beam in Large Helical Device
Authors: Kobayashi T , Yoshinuma M , Ida K 
Published: October 2020

Abstract
A new beam emission spectroscopy system that has improved lines of sight is installed in the Large Helical Device (LHD), and routine measurement has been started in the 21st LHD experiment campaign in 2019–2020. The new system is optimized for hydrogen isotope experiments by equipping a rotatable large-diameter interference filter to be compatible with either the hydrogen or the deuterium beam emission component. An avalanche photo diode detector array having 8 × 8 pixels is used for obtaining a radial–vertical image of electron density fluctuation covering the mid-radius to the plasma periphery. Spatial resolution and wavenumber cutoff are derived from equilibrium reconstruction and plasma kinetic profiles. Obtained fluctuation data is presented for a low field high beta discharge. The spatiotemporal structure of the fluctuations is clearly shown by Fourier correlation analyses.
Partial high frequency nerve block decreases neuropathic signaling following chronic sciatic nerve constriction injury
Authors: Dewberry L Savannah , Dru Alexander B , Gravenstine Maxwell , Nguyen Brian , Anderson James , Vaziri Sasha , Hoh Daniel J , Allen Kyle D , Otto Kevin J 
Published: October 2020

Abstract

Objective. High frequency (HF) block can quickly and reversibly stop nerve conduction. We hypothesized HF block at the sciatic nerve would minimize nociception by preventing neuropathic signals from reaching the central nervous system. Approach. Lewis rats were implanted with a constriction cuff and a distal cuff electrode around their right sciatic nerve. Tactile sensitivity was evaluated using the 50% paw withdrawal threshold (PWT) determined using Chaplan’s method for von Frey monofilaments. Over the course of 49 d, the 50% PWT was measured (1) before HF block, (2) during HF block (50 kHz, 3 V
pp), and (3) after HF block. Gait was observed and scored before and during block. At end point, HF block efficacy was directly evaluated using additional cuff electrodes to elicit and record compound neural action potentials across the HF blocking cuff. Main results. At days 7 and 14 d post-operation, tactile sensitivity was significantly lower during HF block compared to before and after block (p< 0.005). Additionally, an increase in gait disability was not visually observed during HF block. Significance. HF block can reduce tactile sensitivity in a limb with a neuropthic injury in a rapidly reversible fashion.
Quantum-classical correspondence for gl(1|1) supersymmetric Gaudin magnet with boundary
Authors: Vasilyev M , Zabrodin A , Zotov A 
Published: October 2020

Abstract
We extend duality between the quantum integrable Gaudin models with boundary and the classical Calogero–Moser systems associated with root systems of classical Lie algebras B

N
, C

N
, D

N
to the case of supersymmetric gl(m|n) Gaudin models with m + n = 2. Namely, we show that the spectra of quantum Hamiltonians for all such magnets being identified with the classical particles velocities provide the zero level of the classical action variables.
Actigraphy-Derived Sleep Efficiency Is Associated With Endothelial Function in Men and Women With Untreated Hypertension
Authors: Hill LaBarron K , Wu Jade Q , Hinderliter Alan L , Blumenthal James A , Sherwood Andrew 
Published: October 2020

Abstract

BACKGROUND
Poor sleep quality is increasingly recognized as an important and potentially modifiable risk factor for cardiovascular disease (CVD). Impaired endothelial function may be 1 mechanism underlying the association between poor sleep and CVD risk. The present study examined the relationship between objective measures of sleep quality and endothelial function in a sample of untreated hypertensive adults.

METHODS
Participants were 127 men (N = 74) and women (N = 53), including 55 African Americans and 72 White Americans, aged 40–60 years (mean age, 45.3 ± 8.5 years), with untreated hypertension (systolic blood pressure 130–159 mm Hg and/or diastolic blood pressure 85–99 mm Hg). Noninvasive brachial artery flow-mediated dilation (FMD) was assessed by ultrasound. Sleep parameters, including sleep efficiency (SE), total sleep time (TST), and subjective sleep quality, were assessed over 7 consecutive days by wrist actigraphy.

RESULTS
Participants averaged 7.76 ± 1 hours in bed, with an average SE of 78 ± 9%, and TST of 6 ± 1 hours. Brachial FMD averaged 3.5 ± 3.1%. In multivariate analyses controlling for sex, race, body mass index, clinic blood pressure, income, smoking, alcohol use, and baseline arterial diameter, SE was positively associated with FMD (β = 0.28, P = 0.012). Subjective sleep quality (β = −0.04, P = 0.63) and TST (β = −0.11, P = 0.25) were unrelated to FMD.

CONCLUSIONS
Poor sleep as indicated by low SE was associated with impaired FMD. These findings for SE are consistent with previous observations of other measures implicating poor sleep as a CVD risk factor. Interventions that improve sleep may also help lower CVD risk.
Pain, paradox and polysemy
Authors: Liu Michelle 
Published: October 2020

AbstractThe paradox of pain refers to the idea that the folk concept of pain is paradoxical, treating pains as simultaneously mental states and bodily states (as described in papers by Hill and Borg et al.). By taking a close look at our pain terms, this paper argues that there is no paradox of pain. The air of paradox dissolves once we recognize that pain terms are polysemous and that there are two separate but related concepts of pain rather than one.
To boycott proceedings or not? Recourse against arbitral awards on jurisdictional grounds by different categories of respondents under the Model Law
Authors: Chan Darius , Neoh Claire 
Published: October 2020

Abstract
The remedies that award debtors have under Articles 16(3), 34 and 36 of the Model Law, and more critically the inter-relationship between those remedies, has attracted much debate. Yet there is a dearth of analysis on how the availability of each remedy may differ according to the award debtor’s degree of participation in the arbitral process. Such analysis carries significant practical value for parties in considering whether and to what extent they should participate in any arbitral process when they harbour jurisdictional objections. This article distils Singapore’s experience, describing how Singapore has implemented the ‘choice of remedies’ principle for participating, non-participating, and boycotting respondents with jurisdictional objections, with comparative observations from Hong Kong, England, and New Zealand. This article shows that the ultimate matrix of remedies chosen by Singapore is far from straightforward. The question whether a respondent has participated in the arbitral process is also a vexed one. The analysis in this article begs the question whether in pursuit of harmonization future reforms to the Model Law ought to be considered.
Teleneuropsychology for Monolingual and Bilingual Spanish-Speaking Adults in the Time of COVID-19: Rationale, Professional Considerations, and Resources
Authors: Arias Franchesca , Safi Diomaris E , Miranda Michelle , Carrión Carmen I , Diaz Santos Ana L , Armendariz Victoria , Jose Irene E , Vuong Kevin D , Suarez Paola , Strutt Adriana M ,   The STAR Consortium
Published: October 2020

AbstractObjectiveNeuropsychological assessments with monolingual Spanish and bilingual Spanish/English-speaking adults present unique challenges. Barriers include, but are not limited to, the paucity of test norms, uncertainty about the equivalence of translated neuropsychological tests, and limited proficiency in the provision of culturally competent services. Similar issues generalize to telephone- and video-based administration of neuropsychological tests or teleneuropsychology (TeleNP) with Hispanics/Latinos (as), and few studies have examined its feasibility and validity in this group. The sudden onset of the COVID-19 pandemic prompted neuropsychologists to identify alternative ways to provide equitable care. Clinicians providing TeleNP to this population during (and after) the pandemic must consider safety, professional factors, and systemic barriers to accessing and benefitting from virtual modalities.MethodThis clinical process manuscript describes how cross-cultural neuropsychologists across five U.S. academic institutions serving Hispanics/Latinos (as) developed TeleNP models of care during the pandemic.ResultsWorkflows, test batteries, and resources for TeleNP assessment with monolingual and bilingual Spanish-speaking patients are included. Factors guiding model development and informing decisions to incorporate virtual administration of neuropsychological tests into their practice are also discussed.ConclusionsProvision of TeleNP is a promising modality. Additional research in this area is warranted with focus on cultural and contextual factors that support or limit the use of TeleNP with this community.
Are dropout imputation methods for scRNA-seq effective for scHi-C data?
Authors: Han Chenggong , Xie Qing , Lin Shili 
Published: October 2020

AbstractThe prevalence of dropout events is a serious problem for single-cell Hi-C (scHiC) data due to insufficient sequencing depth and data coverage, which brings difficulties in downstream studies such as clustering and structural analysis. Complicating things further is the fact that dropouts are confounded with structural zeros due to underlying properties, leading to observed zeros being a mixture of both types of events. Although a great deal of progress has been made in imputing dropout events for single cell RNA-sequencing (RNA-seq) data, little has been done in identifying structural zeros and imputing dropouts for scHiC data. In this paper, we adapted several methods from the single-cell RNA-seq literature for inference on observed zeros in scHiC data and evaluated their effectiveness. Through an extensive simulation study and real data analysis, we have shown that a couple of the adapted single-cell RNA-seq algorithms can be powerful for correctly identifying structural zeros and accurately imputing dropout values. Downstream analysis using the imputed values showed considerable improvement for clustering cells of the same types together over clustering results before imputation.