bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of sarcopenic obesity and body composition with metabolically unhealthy overweight/obese phenotypes among Iranian women: A cross-sectional study
Authors: Jibril Aliyu Tijani , Mirzababaei Atieh , Shiraseb Farideh , Rasaei Niloufar , Mirzaei Khadijeh - 
Published: December 2020

Abstract
Background

Obesity is a major risk factor for metabolic syndrome, with its prevalence has increased over the past decade. Major changes in body composition with aging have a significant effect on many clinical outcomes. Sarcopenic obesity consists of both the presence of abnormal adipose tissue with a deficit of muscle mass.
Methods

This cross-sectional study was conducted among a total of 241 overweight/obese women aged between 18–48 years in Tehran, Iran, registered by the use of the multistage cluster random sampling method. Blood samples were taken following standard procedures. Body composition was assessed through a multi-frequency bioelectrical impedance analyzer. The metabolic risk was assessed according to Karelis criteria and the subjects were classified as either MHO or MUO phenotypes.
Results

Of the 241 subjects in this study (average age 35.32 years), 176 (73.03%) were classified as MUO phenotype. Based on this study, the prevalence of sarcopenic obesity was 7.88%. We found that high fat-free mass was more strongly and significantly associated with MUO phenotype. Furthermore, we found that individuals with high fat-free mass and high skeletal muscle mass had a significantly low prevalence of MUO phenotype. A significant positive correlation between metabolic phenotypes and sarcopenic obesity was also observed after all potential covariates were adjusted for.
Conclusion

These results of this study suggest that increased adiposity and decreased skeletal muscle mass are associated with unfavorable metabolic traits among overweight and obese Iranian women. SO was also found to be associated with a greater risk of developing MUO phenotype.
How Lived Experience can help Neuroscience Become More Relevant to Mental Health
Authors: Humm Richard , Hanshaw June , Samuels Isaac , Amuda Rosemary , Brandon Claudette , Oliver Ted , Tahir Syeda , Muhxinga Zhenreenah , Thomas Joanne , Perry Sophie , Hugill Cassandra , Barlow Sally , Moutoussis Michael 
Published: December 2020

Abstract
Background: Translational neuroscience aims to make discoveries about the brain that will benefit health, especially mental health. Up to now, however, translational neuroscience studies have been designed with very little input from stakeholders who have lived experience of mental health problems. To address this serious gap, stakeholder participation needs to take place at many levels, as it does in service-oriented studies. Methods: We convened a ‘Lived Experience Advisory Panel’ (LEAP) in order to improve the design of a new study about people’s decision to trust in and continue with, or to stop, psychotherapy treatments. Results: The LEAP productively challenged the ecological validity and relevance of the study design, increasing its potential to improve mental health and to attract research funding. It helped determine the place of lived experience experts in multiple roles within the study throughout its duration. It also helped improve relevance by refining the framing of the therapy-like tasks within the study, and by improving the specification of the study population. LEAP discussions informed the pathways to impact first the consultation process itself, and then the new study. The LEAP convened during the COVID-19 lockdown and its remote work process, described here, demonstrates both the potential for greater involvement of stakeholders in research design, but also some difficulties which future collaborations should address.Conclusion: Involvement of relevant stakeholders very early in the process of designing this research study has improved the study design and its potential to bring positive impacts to those stakeholders. This should be considered broadly across research fields and particularly within translational neuroscience, where limited input by stakeholders with lived experience of mental health problems have been sought to date.
The Effect of Transport Stress on Corticosterone Metabolites in Pheasant Droppings
Authors: Volfova Martina , Machovcova Zuzana , Forejtek Pavel , Voslarova Eva , Bedanova Iveta , Vecerek Vladimir 
Published: December 2020

Abstract
BackgroundTransport has been proven to represent a significant stressor for animals. In view of the fact that pheasants are frequently reared in captivity in hatcheries and are then transported for the purpose of their sale or release, it is essential from the viewpoint of welfare and health protection to obtain as much information as possible about their response to this stressor. The aim of this study was to assess changes in corticosterone metabolite (CM) levels related to transport in common pheasants (Phasianus colchicus). MethodsSixteen birds aged 17 weeks were crated and transported for 3.5 hours (distance travelled 140 km) to the target customer. Individual droppings were collected during the 2 days prior to transport and 3 days after transport. Concentrations of faecal CMs were determined with a non-commercial EIA (enzyme-immunoassay) kit, cortisone was used as a standard and values were expressed as cortisone equivalents in ng per g of droppings. ResultsTransport represents a major stressor for animals and this was also reflected in increased CM concentrations in the droppings in our study. CM concentrations increased within 24 hours of transport (P < 0.01) as compared to pre-transport levels (533.82 ng/g vs. 228.85 ng/g) and continued to rise for another 24 hours (745.35 ng/g). Three days after transport CM concentrations fell back to baseline levels (297.97 ng/g). ConclusionsThe EIA used in this study proved to be sensitive enough to detect biologically meaningful alterations in the adrenocortical activity of pheasants exposed to procedures related to their transport.
Optimisation of BMI-based Images for Overweight and Obese Patients – Implications on Image Quality, Quantitative Accuracy and Radiation Dose in Whole Body 18F-FDG PET/CT Imaging.
Authors: Bouchareb Yassine , Tag Naima , Sulaiman Hajir , Al-Riyami Khulood , Al-Dhuhli Humoud 
Published: December 2020

Abstract
Background - In PET/CT imaging the amount of 18 F-FDG activity injected to patient is mainly based on the patient body weight (BW) or on body mass index (BMI). Imaging overweight and obese patients using standard protocols results quite often in poor diagnostic images. The purpose of this study was to optimise BMI-based whole body 18 F-FDG PET images obtained from overweight and obese patients and assess the added value in terms of image quality, quantitative accuracy and radiation dose in comparison to BW-based images. Methods - The NEMA-IEC-body phantom was scanned on the mCT 128 slices scanner (Siemens Healthineers). The spheres and background were filed with F-18 activity. Spheres-to-background (2.1kBq/mL) ratio was 4:1. Data was reconstructed using the OSEM-TOF-PSF routine reconstruction (2 iterations, 21 subsets, 3mm Gaussian filter). The optimisation was performed by varying number of iterations, number of subsets, filter’s size and type and matrix size. The phantom images were assessed using contrast recovery coefficients (CRCs). The optimised reconstruction was applied to 17 overweight and obese patients. The optimised BMI-based images and BW-based images were compared visually and using signal-to-noise ratio (SNR), SUVmax and SUVpeak measurements. Results- The visual assessment of the optimised phantom images using 1 iteration, 21 subsets, 3mm Hamming filter showed better image quality and CRC values compared to the routine reconstruction. On patient data, the optimised BMI-based images provided better image quality compared to BW-based images in 87.5% of the overweight cases and 66.7% for obese cases. Compared to BW-based images, the optimised BMI-based images resulted in reduction of 18.6% in SUVmax, 10.6% in SUVpeak and 59% in radiation dose for overweight patients. Similar trends were observed in obese patients. SNR improvement on BMI optimised images over BW images was 55% and 59% on overweight and obese patients, respectively. Conclusions - The optimised BMI-based approach using 1 iteration, 21 subsets, 3mm Hamming filter improves image quality, reduces radiation dose and provides, at least, similar quantitative accuracy compared to the BW-based approach for both overweight and obese patients. These findings are compelling enough support to conducting a full assessment of the approach on a large patient population.
Improvement of Mobility, Strength, Stability and Pain in Soccer Players with Recurrent Ankle Sprains Through Myofascial Release, Strength Exercises and Taping: A Randomized Controlled Trial.
Authors: Allois Ruben , Niglia Adriano , Pernice Alessandro , Cuesta-Barriuso Rubén 
Published: December 2020

Abstract
Background. Recurrent ankle sprains are common in soccer players, characterized by restricted range of motion, pain, and decreased proprioception, strength, and postural control. Methods. In this randomized controlled trial over 4 weeks, 36 recreationally active male football players randomly to experimental group (myofascial release applied to the subastragaline joint, eccentric training with an isoinertial device and neuromuscular taping) or control group (same intervention without neuromuscular taping). Outcomes measures were range of motion, strength, stability and perceived pain in the ankle joint. The within-subject effect and group interaction were obtained by means of a repeated measures ANOVA.Results. We found significant differences in range of motion in dorsiflexion (p < 0.001; η2p = 0.31) and plantar flexion (p < 0.01; η2p = 0.23). We also found differences depending on the moment in the strength in dorsiflexion (p = 0.001; η2p = 0.19) and plantar flexion (p < 0.001; η2p = 0.29) and in the intra-subject effect in the variables perceived pain (p = 0.03; η2p = 0.11) and the mean anteroposterior and mid-lateral velocity with eyes open (p < 0.001; η2p = 0.25). No significant changes in group interaction were found in any of the variables (p > 0.05).Conclusion. The combination of fascial therapy and eccentric strength training with an isoinertial device improves ankle mobility, strength and stability in footballers with recurrent ankle sprains. The use of taping techniques failed to provide a greater improvement of the study variables when combined with manual therapy and strength techniques.Trial Registration Number: www.clinicaltrials.gov (id: NCT04257916; Date of registration: 2nd, April, 2020).
Hypersensitive C-reactive Protein to HDL-C Ratio Predicts the Severity of Coronary Artery Disease
Authors: Luo Haorou , Kou Tuli , Yin Lixue 
Published: December 2020

Abstract
Background: Lipid and inflammatory molecules play a key role in the development of coronary atherosclerosis. Hypersensitive C-reactive proteins are used as markers of inflammation duration, and HDL-C is used as an anti-atherosclerosis component. However, few studies have combined the two indicators to explore coronary stenosis. We suggested that Hypersensitive C-reactive proteins as a marker of inflammation persistence and HDL-C as an anti-atherosclerosis component should be integrated into a single biomarker , so as to explore the correlation of Hypersensitive C-reactive protein HDL-C ratio with the severity of coronary stenosis and to predict the severity of coronary stenosis in CAD patients.Methods: We examined 360 eligible patients who underwent coronary angiography. Based on the results of coronary angiography, patients with any major coronary arteries (the left anterior descending artery, the left circumflex artery, the left main coronary artery, the right coronary artery) whose lumen diameter reduced by more than 50% were defined as CAD + group (n = 139) .Patients with luminal stenosis but no more than 50% were defined as CAD- group (n = 41), and patients without luminal stenosis (n = 180) were regarded as control group. The relationship between various serum markers and the severity of coronary stenosis was examined by Spearman correlation analysis. Logistic regression analysis was performed to identify the influencing factors of the severity of coronary artery disease.Results: The modified Gensini score was positively correlated with Hypersensitive C-reactive protein HDL-C ratio . Multiple regression analysis showed that Hypersensitive C-reactive protein HDL-C ratio were significantly associated with CAD. Hypersensitive C-reactive protein HDL-C ratio is an independent predictor of CAD. The ROC analysis provided a cut-off value of 1.17 for Hypersensitive C-reactive protein HDL-C ratio to predict CAD with 83.9% specificity and 0.242 Yoden index, and area under the ROC curve of 0.632 (95%CI 0.571-0.694, P <0.001).At the same time, the area under the ROC curve of Neutrophil HDL-C ratio was 0.620, indicating that Hypersensitive C-reactive protein HDL-C ratio as a predictor of CAD has better diagnostic performance than Neutrophil HDL-C ratio.Conclusion: Hypersensitive C-reactive protein HDL-C ratio is not only closely related to coronary artery stenosis, but also an independent predictor of severe coronary stenosis.
Incidence and Predictors of Hospitalization in Patients with Atrial Fibrillation: Results from the Chinese Atrial Fibrillation Registry Study
Authors: Dong Zhaojie , Du Xin , Lu Shangxin , Jiang Chao , Xia Shijun , He Liu , Su Xin , Jia Zhaoxu , Long Deyong , Sang Caihua , Tang Ribo , Liu Nian , Bai Rong , Yu Ronghui , Dong Jianzeng , Ma Changsheng 
Published: December 2020

Abstract
Background: Patients with atrial fibrillation (AF) underwent a high risk of hospitalization, which, however, has not been paid much attention in clinic. Therefore, we aimed to assess the incidence, causes and predictors of hospitalization in AF patients.Methods: From August 2011 to December 2017, 20,172 AF patients from the Chinese Atrial Fibrillation Registry (China-AF) Study were enrolled in this study. We described the incidence, causes of hospitalization according to age and gender categories. The Cox proportional hazards model was employed to identify predictors of first all-cause and first cause-specific hospitalization. Results: After a mean follow-up of 37.3 ± 20.4 months, 7,512 (37.2%) AF patients experienced one or more hospitalizations. The overall incidence of all-cause hospitalization was 24.0 per 100 patient-years. Patients aged < 65 years were predominantly hospitalized for AF (42.1% of the total frequency of hospitalizations); while patients aged 65-74 and ≥ 75 years were mainly hospitalized for non-cardiovascular diseases (43.6% and 49.3%, respectively). Multivariate Cox model analysis verified the higher risk of hospitalization in patients complicated with heart failure (HF)[hazard ratio (HR) 1.15, 95% confidence interval (CI) 1.08-1.24], established coronary artery disease (CAD) (HR 1.26, 95%CI 1.19-1.34), ischemic stroke/transient ischemic attack (TIA) (HR 1.26, 95%CI 1.18-1.33), diabetes (HR 1.16, 95%CI 1.10-1.22), chronic obstructive pulmonary disease (COPD) (HR 1.41, 95%CI 1.13-1.76), gastrointestinal disorder (HR 1.39, 95%CI 1.23-1.58), and renal dysfunction (HR 1.31, 95%CI 1.16-1.48). Conclusions: More than one-third of AF patients included in this study were hospitalized at least once during almost 3 years of follow-up. The main cause for hospitalization among elderly patients (≥65 years) is non-cardiovascular diseases rather than AF. Multidisciplinary management of comorbidities should be advocated as strategies to reduce hospitalization in AF patients.Clinical Trial Registration: URL: http://www.chictr.org.cn/showproj.aspx?proj=5831. Unique identifier: ChiCTR-OCH-13003729.
Effects of Ontogenetic Development on Seedling Regeneration Dynamics of Quercus Acutissima Plantation in Mount Tai
Authors: Guo Longmei , Li Zexiu , Lin Qingzhi , Mao Peili , Cao Banghua , Yu Caiyun , Gao Peng , Dong Jinwei , Zhao Boping 
Published: December 2020

Abstract
Background: Natural regeneration is critically important for the sustainable management of artificial forests. Studies have been investigated for the effects of seedlings height distribution and ontogenetic adaptability in a 60-year-old Quercus acutissima artificial pure forest in Mount Tai. Results: The results showed that the height distribution of seedlings under the forest was pyramidal-shape from the year 2010 to 2017. In 2017, the density of seedlings under the forest was only 61.63% of that in 2010, and the number of individuals at each height class was lower than that in 2010, especially the individuals at 20-40cm height class only 32% of that in 2010. With the increase of seedling height under the forest, seedling biomass (SB), ground diameter (GD), root mass ratio (RMR), total root length (TRL), root volume (RV), root average diameter (RAD) and nonstructural carbohydrates (NSC) increased significantly, but leaf mass ratio (LMR), leaf area ratio (LAR), photosynthetic/non-photosynthetic tissue ratio (P/NP), specific root length (SRL) and specific root surface area (SRA) decreased significantly. Correlation analysis showed that SB was negatively correlated with LMR, LAR, P/NP, SRL and SRA, and positively correlated with RMR, TRL, RV, RAD and NSC. NSC was negatively correlated with LMR, LAR, P/NP, SRL and SRA. Conclusions: Therefore, with the increase of seedlings height, the increased carbon storage was helpful for the seedlings of Q. acutissima to survive under the forest for a long time, but the reduced ability of light interception, photosynthetic tissue ratio, water and nutrient absorption capacity contributed to their low survival ratio under the forest.
pH Dependent Delivery of Chlorhexidine From PLGA Grafted Mesoporous Silica Nanoparticles at Resin-Dentin Interface
Authors: Akram Zohaib , Aati Sultan , Ngo Hein , Fawzy Amr 
Published: December 2020

Abstract
Background: A low pH environment is created due to the production of acids by oral biofilms that further leads to the dissolution of hydroxyapatite crystal in the tooth structure significantly altering the equilibrium. Although the overall bacterial counts may not be eradicated completely from the oral cavity, however, synthesis of engineered anti-bacterial materials are warranted in order to reduce the pathogenic impact of the oral biofilms. The purpose of this study was to synthesize and characterize chlorhexidine-loaded mesoporous silica nanoaprticles (MSN) grafted with poly-L-glycolic acid (PLGA) and to test the in vitro drug release in various pH environments, cytotoxicity, and antimicrobial capacity. In addition, to investigate the delivery of CHX-loaded/MSN-PLGA through dentin tubules of demineralized dentin substrates and the interaction of these nanoparticles with commercial dentin adhesive after applying it on demineralized substrates for potential clinical application.Results: Characterization using SEM/TEM and EDX confirmed the synthesis of CHX-loaded/MSN-PLGA. An increase in the percentage of drug encapsulation efficiency from 81% to 85% in CHX loaded/MSN and 92% to 95% in CHX loaded/MSN-PLGA proportionately increased with increasing the amount of CHX during the fabrication of nanoparticles. For both time-periods (24 h or 30 Days), the relative microbial viability significantly decreased by increasing the CHX content (P<0.001). Generally, the cell viability percentage of DPSCs exposed to MSN-PLGA/Blank, CHX-loaded/MSN, and CHX-loaded/MSN-PLGA, respectively was >80% indicating low cytotoxicity profiles of experimental nanoparticles. After 9 months in artificial saliva (pH 7.4), significantly highest micro-tensile bond strength value was recorded for 25:50 CHX/MSN and 25:50:50 CHX/MSN-PLGA. A homogenous and widely distributed 50:50:50 CHX-loaded/MSN-PLGA nanoparticles exhibited excellent bonding with the application of commercially available dentin adhesive.Conclusions: A pH sensitive CHX release response was noted when loaded in MSN grafted PLGA nanoparticles. The formulated drug loaded nanocarrier demonstrated excellent physicochemical, spectral, and biological characteristics. Showing considerable capacity to penetrate effectively inside dentinal tubules and having high antibacterial efficacy, this system could be potentially used in adhesive and restorative dentistry.
One World Project's Wheelchair Skills Training Camp in Morocco – Effects of a Community Peer-Based Programme
Authors: Tasiemski Tomasz , Wilski Maciej , Urbański Piotr 
Published: December 2020

Abstract
Background. Access to health services was found to be a major problem for over half of persons with disabilities in Morocco. This has created the need to increase opportunities for community-based rehabilitation activities in this country.The aim of this study was to assess wheelchairs skills of persons with physical disabilities attending the first Wheelchair Skills and Empowerment Camp in Morocco, and their satisfaction with the manual wheelchairs available during the camp activities. Methods. 19 persons (13 male and 6 female) with physical disabilities took part in the project. Mean years since injury or illness was 24 years. The following measures have been used: the Queensland Evaluation of Wheelchair Skills test, and the Quebec User Evaluation of Satisfaction with assistive Technology. Results. Study participants improved their overall wheelchair mobility skills (p=0.002; d=0.20), especially the ability to ascend and descend a ramp (p=0.012; d=0.67). The participants were significantly larger satisfied with the new provided wheelchairs in comparison to their own wheelchairs with regard to five of the satisfaction items i.e. ease in adjusting (p=0.011; d=0.96), safety and security (p=0.014; d=0.97), durability (p=0.037; d=0.81), ease to use (p=0.045; d=0.87), and comfort (p=0.006; d=1.03). Conclusions. Findings of this study suggest that there is a need for structured wheelchair skills training and better-quality wheelchairs for persons with physical disabilities in Morocco. The study also confirmed that community peer-based programmes in low-resource countries can play an important role in rehabilitation in persons with physical disabilities, even many years since their injury or illness.