bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mother-teacher-scholar-advocates: narrating work-life on the professorial plateau
Authors: Lowenstein Elisabeth , Jones Darolyn “Lyn” 
Published: November 2020

PurposeIn this study, two mother-scholars describe their lived experiences working in higher education in the USA while parenting children with disabilities. They situate their narratives within the context of institutionalized motherhood, courtesy stigma and the career plateau experienced by many working mothers of children with disabilities.Design/methodology/approachWithin this collaborative autoethnography, the authors employ autoethnographic narrative and poetic inquiry.FindingsThe authors reveal unique work-life tensions that they have experienced as mothers, teachers and scholars, reflecting on the experiences that led them to become advocates for people and families with disabilities.Practical implicationsThe authors aim to reduce stigma and to disrupt the career plateau by offering suggestions to help coworkers and supervisors be more supportive of working parents of children with disabilities.Originality/valueThe authors enumerate the advantages of collaborative autoethnography in uncovering how stigma against mothers of children with disabilities is manifested within an academic community.
Deflating power imbalance through personal identity enhancement
Authors: Mishra Shreya , Chaudhuri Manosi , Dey Ajoy Kumar 
Published: November 2020

PurposeThe purpose of the paper is to identify how the intersection of power, context, subjectivity and directionality makes it possible for the targets of workplace bullying to deflate power imbalance between them and the perpetrators.Design/methodology/approachThe paper is based on nine in-depth interviews with self-reported targets from different public sector organizations in India. The targets were purposively selected keeping in mind that they made deliberate attempts to counter bullying. Constructivist grounded theory approach was used to analyze the data.FindingsSix themes emerged as sources of power imbalance and eight themes as the way of deflating power imbalance. The core category that emerged was “enhancing personal identity”, which was the underlying phenomenon leading to deflation of power imbalance, through the intersection of power, context, subjectivity and directionality.Research limitations/implicationsThe study indicates that power, context, subjectivity and directionality of bullying help the targets to identify effective strategies of deflating power imbalance. In the process, the targets indulge in personal identity enhancement. It further reinforces the understanding that power does not remain static and may shift from the perpetrator to the target of bullying.Practical implicationsThe study provides various tactics that targets can use to counter workplace bullying. It implies that targets need not always leave the organization or succumb to the situation in order to deal with bullying. It encourages the targets of bullying and those who deal with bullying targets to indulge in personal identity enhancement through problem-focused strategies of tackling workplace bullying.Originality/valueIt also furthers our understanding of workplace bullying from the point of intersection of the four aspects of the phenomenon – power, context, subjectivity and directionality – which allows the targets of bullying to enhance their personal identity.
Misunderstandings about older people fuel corona virus complacency
Authors: Altshuler Ellery 
Published: November 2020

Purpose
The purpose of this paper is to explore public assumptions underlying the apparent disregard for the lives of older people during the coronavirus outbreak. It attempts to dispel myths about quality of life among older people.

Design/methodology/approach
This paper integrates the author’s personal experiences as a doctor with data collection, which involved general PubMed searches for articles relating to the public response to the effect of coronavirus on older people; beliefs about the lives of older people; and issues of happiness, contentedness and quality of life in older people.

Findings
Some people have concluded that the lives of older people – which they believe to be of low quality – are worth risking to lessen the economic impact of coronavirus. This morbid calculation is based in part on the assumption that older people are less happy than younger people. In fact, the evidence shows that as people get older, they become significantly happier.

Originality/value
This paper asks readers to explore their assumptions about ageing and reaffirms the importance of protecting older people in the midst of the coronavirus pandemic.
Hesperidin inhibits L‐NAME‐induced vascular and renal alterations in rats by suppressing the renin–angiotensin system, transforming growth factor‐β1, and oxidative stress
Authors: Bunbupha Sarawoot , Apaijit Kwanjit , Potue Prapassorn , Maneesai Putcharawipa , Pakdeechote Poungrat 
Published: November 2020

AbstractThe protective effect of hesperidin on vascular and renal alterations and possible underlying mechanisms involved in Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME)‐induced hypertensive rats were investigated in this study. Male Sprague‐Dawley rats were administered L‐NAME (40 mg/kg/day), L‐NAME plus hesperidin (30 mg/kg/day), and L‐NAME plus captopril (2.5 mg/kg/day) for 5 weeks. Hesperidin and captopril significantly prevented L‐NAME‐induced hypertension, vascular and renal dysfunction, intrarenal artery remodelling, glomerular extracellular matrix accumulation, and renal fibrosis. The preventive treatment with hesperidin and captopril also significantly decreased serum angiotensin‐converting enzyme activity and plasma transforming growth factor‐β1 (TGF‐β1) levels and downregulated angiotensin II receptor type I and TGF‐β1 protein expression in the kidneys. In addition, decreased malondialdehyde levels and increased superoxide dismutase activity in the plasma and kidney were observed after co‐treatment with hesperidin or captopril. These findings suggest that hesperidin inhibits L‐NAME‐induced vascular and renal alterations in rats. The possible mechanism may be related to the suppression of the activation of the renin–angiotensin system and expression of TGF‐β1, and reduction of oxidative stress.
Differences in the fruit removal patterns of Cleyera japonica by frugivorous birds in two forest stands at different developmental stages in a warm‐temperate region
Authors: Araki Nana , Hirayama Kimiko 
Published: November 2020

AbstractWe investigated the fruit removal patterns of Cleyera japonica by frugivorous birds in two adjacent forest stands at different developmental stages due to secondary succession (a secondary deciduous forest stand, and an evergreen forest stand where evergreen oak is the dominant species) in a warm‐temperate region in western Japan. The fruit removal rate was significantly higher in the evergreen forest stand than in the deciduous forest stand, whereas the abundance of C. japonica fruits and that of all fleshy‐fruited woody species did not positively affect the fruit removal. However, the Cox proportional‐hazards model with mixed effects, using data concerning the disappearing patterns of mature fruits from twigs, implied that the fruit removal of C. japonica by birds within the crown was not significantly different from that between the stands. The timing of seed dispersal of C. japonica was prolonged in the evergreen forest stand compared with that in the deciduous forest stand. In the evergreen forest stand, considerable numbers of seeds were found in seed traps after early January, when almost all the fruits had disappeared from the crown. In the evergreen forest stand, we constantly observed gulpers that are assumed to forage C. japonica fruits frequently on the ground. These results suggested that the differences in the structural attributes between the forest stands influence the bird assemblage and their foraging patterns, which would lead to changes in the fruit removal patterns of C. japonica with the shift of forest stands due to secondary succession.
Evidence for non‐methanogenic metabolisms in globally distributed archaeal clades basal to theMethanomassiliicoccales
Authors: Zinke Laura A. , Evans Paul N. , Santos‐Medellín Christian , Schroeder Alena L. , Parks Donovan H. , Varner Ruth K. , Rich Virginia I. , Tyson Gene W. , Emerson Joanne B. 
Published: November 2020

SummaryRecent discoveries ofmcrandmcr‐like genes in genomes from diverse archaeal lineages suggest that methane metabolism is an ancient pathway with a complicated evolutionary history. One conventional view is that methanogenesis is an ancestral metabolism of the classThermoplasmata. Through comparative genomic analysis of 12Thermoplasmatametagenome‐assembled genomes (MAGs) basal to theMethanomassiliicoccales, we show that these microorganisms do not encode the genes required for methanogenesis. Further analysis of 770Ca. Thermoplasmatota genomes/MAGs found no evidence ofmcrAhomologues outside of theMethanomassiliicoccales. Together, these results suggest that methanogenesis was laterally acquired by an ancestor of theMethanomassiliicoccales. The 12 analysed MAGs include representatives from four orders basal to theMethanomassiliicoccales, including a high‐quality MAG that likely represents a new order,Ca. Lunaplasma lacustris ord. nov. sp. nov. These MAGs are predicted to use diverse energy conservation pathways, including heterotrophy, sulfur and hydrogen metabolism, denitrification, and fermentation. Two lineages are widespread among anoxic, sedimentary environments, whereasCa. Lunaplasma lacustris has thus far only been detected in alpine caves and subarctic lake sediments. These findings advance our understanding of the metabolic potential, ecology, and global distribution of theThermoplasmataand provide insight into the evolutionary history of methanogenesis within theCa. Thermoplasmatota.
Verticillium dahliae VdBre1 is required for cotton infection by modulating lipid metabolism and secondary metabolites
Authors: Wang Huan , Chen Bin , Tian Juan , Kong Zhaosheng 
Published: November 2020

SummaryThe soil‐borne ascomycete Verticillium dahliae causes wilt disease in more than two hundred dicotyledonous plants including the economically important crop cotton, and results in a severe reduction in cotton fiber yield and quality. During infection, V. dahliae secretes numerous secondary metabolites, which act as toxic factors to promote the infection process. However, the mechanism underlying how V. dahliae secondary metabolites regulate cotton infection remains largely unexplored. In this study, we report that VdBre1, an ubiquitin ligase (E3) enzyme to modify H2B, regulates radial growth and conidia production of V. dahliae. The VdBre1 deletion strains show nonpathogenic symptoms on cotton, and microscopic inspection and penetration assay indicated that penetration ability of the ∆VdBre1 strain was dramatically reduced. RNA‐seq revealed that a total of 1643 differentially expressed genes between the ∆VdBre1 strain and the wild type strain V592, among which genes related to lipid metabolism were significantly overrepresented. Remarkably, the volume of lipid droplets in the ∆VdBre1 conidia was shown to be smaller than that of wild‐type strains. Further metabolomics analysis revealed that the pathways of lipid metabolism and secondary metabolites, such as steroid biosynthesis and metabolism of terpenoids and polyketides, have dramatically changed in the ∆VdBre1 metabolome. Taken together, these results indicate that VdBre1 plays crucial roles in cotton infection and pathogenecity, by globally regulating lipid metabolism and secondary metabolism of V. dahliae.
The association between threatened preterm labour and perinatal outcomes at term: a population‐based cohort study
Authors: Gagnon LC , Allen VM , Crane JM , Jangaard K , Brock J‐AK , Woolcott CG 
Published: November 2020

ObjectiveTo estimate the association between threatened preterm labour (TPTL) and perinatal outcomes of infants born at term.DesignA population‐based cohort study of perinatal outcomes following TPTL <37 weeks of gestation with delivery at term.SettingNova Scotia, Canada.PopulationAll non‐anomalous, singleton pregnancies ≥37 weeks of gestation without antepartum haemorrhage from 1988 to 2019.MethodsUsing data from the Nova Scotia Atlee Perinatal Database, TPTL was defined as pregnancies with a hospital admission between 20 and 37 weeks of gestation, with a diagnosis code denoting TPTL with administration of antenatal corticosteroids, or with administration of any tocolysis. Poisson regression models were used to estimate the risk ratios (RR) with 95% CI of maternal and perinatal outcomes in women who had an episode of TPTL relative to those who did not.Main outcome measuresBirthweight for gestational age below the tenth centile and a composite of perinatal mortality or severe perinatal morbidity.ResultsOf 256 599 term deliveries meeting the inclusion criteria, 2278 (0.9%) involved TPTL. The risks of the primary outcomes were higher among those with TPTL relative to those without: birthweight for gestational age below the tenth centile (RR 1.24, 95% CI 1.11–1.39) and the composite of perinatal mortality/severe perinatal morbidity (RR 1.33, 95% CI 1.15–1.54).ConclusionsAlthough the prevalence of TPTL in term deliveries is low, affected pregnancies are at increased risk for adverse perinatal outcomes. Increased fetal surveillance should be considered in the management of pregnancies affected by TPTL.
Tissue surface area and tumor cell count affect the success rate of the Oncomine Dx Target Test in the analysis of biopsy tissue samples
Authors: Nemoto Daiji , Yokose Tomoyuki , Katayama Kayoko , Murakami Shuji , Kato Terufumi , Saito Haruhiro , Suzuki Masaki , Eriguchi Daisuke , Samejima Joji , Nagashima Takuya , Ito Hiroyuki , Yamada Kouzo , Nakayama Haruhiko , Masuda Munetaka 
Published: November 2020

AbstractBackgroundThe Oncomine Dx Target Test (ODxTT) is a next‐generation sequencing‐based companion diagnostic test which has been recently developed; however, its analysis success rate could be improved, especially for small samples. The aim of this study was to identify the pathological factors associated with biopsy specimens that affect the analysis success rate of ODxTT.MethodsWe retrospectively investigated 119 cases subjected to ODxTT at Kanagawa Cancer Center. Data pertaining to the results of BRAF V600E mutation analysis in ODxTT and pathological factors based on microscope slides were collected. Pathological factors including tissue surface area, tumor cell count, and tumor content rate were assessed. We constructed receiver operating characteristic curves and determined the optimal cutoff values of each pathological factor. Multivariate logistic analysis was used to identify significant factors.ResultsA total of 98 of 119 samples were successfully analyzed (75.6%). The tissue surface area and tumor cell count were significantly higher in the group associated with analysis success (P < 0.001 and P = 0.011, respectively), and their optimal cutoff values were 1.04 mm2 and 375 cells, respectively. A tissue surface area > 1.04 mm2 and tumor cell count >375 cells had a positive effect on the analysis success rate of ODxTT (odds ratio [OR] 0.10; 95% confidence interval [CI]: 0.03–0.35; P < 0.001 and OR 0.25; 95% CI: 0.07–0.90; P = 0.033, respectively).ConclusionsSelecting samples with a tissue surface area > 1.04 mm2 and a tumor cell count >375 cells might improve the analysis success rate of ODxTT.Key pointsSignificant findings of the study: We found that a tissue surface area > 1.04 mm2 and tumor cell count >375 cells had a positive effect on the analysis success rate of ODxTT in the analysis of biopsy tissue samples.What this study adds: It is sometimes necessary to assess genetic alterations with a small biopsy sample in daily practice. The criteria mentioned above will help to determine which tests should be performed, ODxTT or multiple single‐gene testing.
Time‐concentration interplay in insecticide resistance among populations of the Neotropical coffee leaf miner, Leucoptera coffeella
Authors: Leite Suzany A. , dos Santos Mateus P. , da Costa Daniela R. , Moreira Aldenise A. , Guedes Raul Narciso C. , Castellani Maria A. 
Published: November 2020

Leucoptera coffeella is one of the main coffee pests in the Neotropical region and particularly important in crops cultivated under full sun, as in Brazil. The intensive use of insecticides in the last two decades, including molecules of recent use such as chlorantranilprole, has not been successful in suppressing this pest species.
Thus, study aimed to detect insecticide resistance and determine the levels of resistance to commercial formulations of the insecticides chlorantraniliprole, chlorpyrifos and thiamethoxam in populations of L. coffeella from Arabica coffee fields in western and the highlands of the state Bahia (Brazil). Furthermore, as the expression of insecticide toxicity varies with the length of exposure and the compound concentration, what is frequently neglected, these two variables were considered while determining the levels of resistance in nine populations.
Moderate levels of resistance were detected to chlorantranilprole in two populations, whereas the others exhibited low levels of resistance. All populations were resistant to thiamethoxam ranging from low to moderate levels. Low levels of resistance to chlorpyrifos were detected in all populations from western, but none from highlands region.
The western presents a more concerning scenario of insecticide resistance the L. coffeella, but the phenomenon requires attention in both regions.
Grasses cope with high‐contrast ecosystem conditions in the large outflow of the Banhine wetlands, Mozambique
Authors: Zaplata Markus Klemens , Nhabanga Abel , Stalmans Marc , Volpers Thomas , Burkart Michael , Sperfeld Erik 
Published: November 2020

AbstractEcosystems with highly pulsed water supply must be better understood as climate change may increase frequency and severity of intense storms, droughts and floods. Here we collected data over 3 years (2016–2018) in the episodic wetland outflow channel (Aluize), Banhine National Park, in which the system state changed from dry to wet to dry. Field sampling included vegetation records, small‐scale vegetation zoning, the seed bank and water and soil quality. The same main plant species were found in both dry and wet conditions across the riverbed of the outflow channel. We found only very few diaspores of plants in the soil after prolonged drought. In the subsequent flooded state, we examined very dense vegetation on the water surface, which was dominated by the gramineous speciesPaspalidium obtusifolium. This species formed a compact floating mat that was rooted to the riverbed. The CyperaceaeBolboschoenus glaucusshowed high clonal growth in the form of root tubers, which likely serve as important food reservoir during drought. Soil and water analyses do not indicate a limitation by nutrients. We outline how resident people may change the plant community structure with an increasing practice of setting fire to the meadows in the dried‐up riverbed to facilitate plant regrowth as food for their livestock.
Epigenetic modification‐dependent androgen receptor occupancy facilitates the ectopic TSPY1 expression in prostate cancer cells
Authors: Leng Xiangyou , Liu Mohan , Tao Dachang , Yang Bo , Zhang Yangwei , He Tianrong , Xie Shengyu , Wang Zhaokun , Liu Yunqiang , Yang Yuan 
Published: November 2020

AbstractTestis‐specific protein Y‐encoded 1 (TSPY1), a Y chromosome‐linked oncogene, is frequently activated in prostate cancers (PCa) and its expression is correlated with the poor prognosis of PCa. However, the cause of the ectopic transcription of TSPY1 in PCa remains unclear. Here, we observed that the methylation status in the CpG islands (CGI) of the TSPY1 promoter was negatively correlated with its expression level in different human samples. The acetyl‐histone H4 and trimethylated histone H3‐lysine 4, two post–translational modifications of histones occupying the TSPY1 promoter, facilitated the TSPY1 expression in PCa cells. In addition, we found that androgen accelerated the TSPY1 transcription on the condition of hypomethylated of TSPY1‐CGI and promoted PCa cell proliferation. Moreover, the binding of androgen receptor (AR) to the TSPY1 promoter, enhancing TSPY1 transcription, was detected in PCa cells. Taken together, our findings identified the regulation of DNA methylation, acting as a primary mechanism, on TSPY1 expression in PCa, and revealed that TSPY1 is an androgen‐AR axis‐regulated oncogene, suggesting a novel and potential target for PCa therapy.
Aberrant expression of junctional adhesion molecule‐A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155
Authors: Murakami Taro , Takasawa Akira , Takasawa Kumi , Akimoto Taishi , Aoyama Tomoyuki , Magara Kazufumi , Saito Yuki , Ota Misaki , Kyuno Daisuke , Yamamoto Soh , Hasegawa Tadashi , Saito Tsuyoshi , Osanai Makoto 
Published: November 2020

AbstractRecent studies have shown that aberrant expression of tight junction proteins (TJP) contributes to malignant potential of various cancers. In the present study, we investigated the expression of junctional adhesion molecule‐A (JAM‐A), one of the transmembrane TJP, in uterine cervical adenocarcinoma and the significance of its expression for malignancy. Immunohistochemistry on human surgical specimens showed that JAM‐A was aberrantly expressed in neoplastic regions including adenocarcinoma in situ (AIS). Knockout of JAM‐A significantly suppressed cell proliferation and colony‐forming and migration abilities. We also showed that an antibody specific to an extracellular region of JAM‐A reduced cell proliferation ability and that loss of JAM‐A increased drug sensitivity of cervical adenocarcinoma cells. Based on a comprehensive proteome analysis, we found that poliovirus receptor (PVR/CD155) was regulated by JAM‐A and formed a physical interaction with JAM‐A. In human surgical specimens, PVR/CD155 expression was significantly correlated with some clinicopathological features and prognosis of cervical adenocarcinoma. Interestingly, most of the PVR/CD155‐positive cases expressed a high level of JAM‐A, and patients with the expression pattern of PVR/CD155 positive/JAM‐A high had significantly shorter periods of relapse‐free survival (P = .00964) and overall survival (P = .0204) than those for the other patients. Our observations suggest that aberrant expression of JAM‐A promotes malignancy of uterine cervical adenocarcinoma by regulation of PVR/CD155, and JAM‐A is therefore a potential therapeutic target for this malignancy.
Welcome to the Museum: Reflecting on Representation & Inclusion in Museum Evaluation
Authors: Anderson Alice , Mileham Michelle A. 
Published: November 2020

Abstract“Welcome to the Museum: Reflecting on the Representation and Inclusion in Museum Evaluation” examines how museums have embraced people with different identities (or not) in the last few decades. Drawing on Curator: The Museum Journal’s archives and other museum scholarship, the authors track the impacts of these actions on staffing and professional practice in the profession of museum evaluation. Based on this research, Anderson and Mileham recommend a thorough process of reflection on the level of individuals, departments, and institutions in order to make museum evaluation – and museums writ large – welcoming and supportive of workers and visitors with a variety of identities and perspectives.