bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baryon-Dark matter interaction in presence of magnetic fields in light of EDGES signal
Authors: Bhatt Jitesh R. , Natwariya Pravin Kumar , Nayak Alekha C. , Pandey Arun Kumar 
Published: April 2020

AbstractWe have shown that in presence of a cosmic magnetic field the bounds on baryon dark matter cross-section ($${\hat{\sigma }}$$σ^), dark-matter mass ($$m_d$$md) and values of the magnetic field ($$B_0$$B0) can strongly influence each other. This requires to rework the bounds on $${\hat{\sigma }}\,$$σ^, $$m_d$$md and $$B_0$$B0 which can explain the observed absorption signal by EDGES collaboration. The upper limit on the magnetic field strength can modify in presence of baryon-dark matter interaction cross-section. In the presence of a strong magnetic field, a large baryon-dark matter interaction cross-section is required to balance magnetic heating of gas to explain the EDGES signal as compared to a weak magnetic field. Subsequently, the strong magnetic-fields can even erase the 21 cm signal–this gives an upper bound on the strength of magnetic-fields, dark-matter mass and baryon-dark matter cross-section. In the special case when $${\hat{\sigma }}$$σ^ = 0, one can recover the bound on magnetic field strength calculated in [1]. In this work we find that the allowed range of the primordial magnetic field can increase by three orders of magnitude in comparison with [1]. We get upper bound on the magnetic field strength: $$3.48\times 10^{-6}$$3.48×10-6 G for the dark matter mass $$\lesssim 10^{-2}$$≲10-2 GeV.
An anisotropic model for represent compact stars
Authors: Estevez-Delgado Joaquin , Cabrera Jose Vega , Ceballos Joel Arturo Rodriguez , Paulin-Fuentes Jorge Mauricio 
Published: April 2020

Starting from a perfect fluid solution we constructed a generalization with anisotropic pressures and regular geometry as well as the pressures, the density and the speed of sound, these are also positive and monotonic decreasing functions. The speed of sound is lower than the speed of light, that is to say, the condition of causality is not broken. The model satisfies all the energy conditions and the radial [Formula: see text] and tangential [Formula: see text] speeds and complies with [Formula: see text] because of this the solution is stable according to the stability criteria related with the concept of cracking. The maximum value of the compactness factor [Formula: see text] which is lower than the Buchdahl limit and associated to neutron stars. In a complementary manner, we realize an analysis of the behavior of a star with a mass of [Formula: see text], with a fixed value of the anisotropy parameter and different compactness values, giving as a result that their central density [Formula: see text] and the superficial density [Formula: see text], the maximum values match the value of greater compactness of the model with a stellar radius of 6506.921 m.
Preventive Effect of Alginate Gel Formulation on Perineural Adhesion
Authors: Hachinota Ai , Tada Kaoru , Yamamoto Daiki , Nakajima Tadahiro , Nakada Mika , Tsuchiya Hiroyuki 
Published: April 2020

Background: Perineural adhesion is a potential complication of manipulating peripheral nerves. Using a model of median nerve manipulation in the carpal tunnel, perineural adhesion preventive effects of an alginate gel formulation were examined.Methods: After exposing carpal tunnels of Japanese white rabbits and dissecting the median nerve, the gliding floor was excised as much as possible and the transverse carpal ligament was repaired to induce a perineural tissue reaction. Prior to wound closure, 0.5 ml of alginate gel formulation was administered into the right carpal tunnel (formulation group) and 0.5 ml of physiological saline was administered into the left carpal tunnel (control group). At 1, 2, 3, and 6 weeks after treatment, electrophysiological evaluation of thenar distal latency, macroscopic evaluation with adhesion score, and pathological evaluation of carpal tunnel cross sections were performed (N = 4–5 at each time point).Results: Although distal latency tended to be low in the formulation group, there was no significant difference between the groups according to electrophysiological evaluation. Macroscopic evaluation revealed that the adhesion score was always lower in the formulation group than in the control group; over the course of treatment, it remained unchanged in the formulation group, but peaked at 3 weeks after treatment in the control group. In pathological evaluation, neural perfusion peaked at 2–3 weeks after treatment in both groups; neural perfusion tended to be lower in the formulation group than in the control group.Conclusions: Results suggested that the peak tissue response associated with nerve dissection occurred 2–3 weeks after treatment and that the repair process started subsequently. The alginate gel formulation modified the surrounding environment of the nerve and promoted repair by acting as a physical barrier against perineural fibrosis. The preventive effect of alginate gel on perineural adhesion may improve treatment outcomes of constrictive neuropathy.
Volar Cortical Integrity in Non-Operatively Treated Adult Distal Radius Fractures
Authors: Erickson John , Lopez Wylie , Shonuga Owolabi , Azzolini Anthony , Tyler David , Monica James 
Published: April 2020

Background: We sought to independently validate published data that volar cortical integrity (VCI) is an independent predictor of maintenance of closed reduction in a series of non-surgically treated distal radius fractures, while simultaneously investigating previously reported predictors of instability. Our null hypothesis was that volar cortical integrity would not affect maintenance of reduction. Methods: Four hundred thirty-three adult distal radius fractures were screened from our Orthopedic database with 112 meeting inclusion criteria. Two groups were determined on the basis of maintenance of reduction (MOR) or loss of reduction (LOR) at 5–6 weeks post-reduction. Bivariate analysis was applied to previously published instability factors along with VCI. A forward stepwise logistic regression was then used to identify instability factors that, as a group, are most predictive of outcome. Results: Results of 112 patients were collected. Reduction was maintained in 62 patients (55.35%) at 5–6 weeks Biivariate analysis showed a statistically significant difference in volar cortical integrity between the 2 groups (80.6% MOR vs 59.2% LOR). Forward stepwise logistic regression analysis of subgroups revealed that post-reduction radial height and VCI were together statistically significant in the model. The presence of VCI, post-reduction radial height greater than or equal to ulnar neutral at the time of initial reduction resulted in a 67.8% successful MOR. Conclusions: We were able to confirm the importance of volar cortical integrity as a predictor of successful maintenance of reduction in non-surgically managed distal radius fractures. When combined with post-reduction radial height greater than or equal to ulnar neutral at the time of initial reduction, it showed a 67.8% MOR with non-operative management in our data-set.
Outcomes Following Open Reduction and Internal Fixation in Proximal Phalangeal Fracture with Rotational Malalignment
Authors: Lee Jun-Ku , Hong In-Tae , Cho Jin Woo , Ha Cheungsoo , Yu Woo-Jin , Han Soo-Hong 
Published: April 2020

Background: The rotational malalignment in proximal phalanx fracture is unacceptable. Authors attempted to describe clinical and radiographic outcomes as well as complications after open reduction and internal fixation with screw only or plate for phalangeal fractures accompanied by rotational malalignment.Methods: Authors conducted a retrospective review of 46 patients who had been treated between Jan. 2010 and Dec. 2016. The average follow-up period was 16.7 months. A total active motion (TAM), Disability of Arm, Shoulder and Hand score (DASH), and tip pinch power between thumb and fractured finger were measured at the final follow-up. Complications were investigated during the follow up. We assessed the amount of rotation by measuring angle between 3rd ray and fractured finger. The measurement was divided into two groups depending on rotation direction, divergent and convergent direction group.Results: Twenty-eight cases were fixed with mini LCP plate, 12 cases with lag screws, and rest 6 cases with combined. All patients showed solid bony union on radiographs on average follow-up of 68 days (range, 41–157 days). Average TAM of the injured finger was 244 degrees and average DASH score was 4.9 at the last follow-up. Tip pinch power was 3.2 kg, which was not significantly different from that of the contralateral side at 3.4 kg (p = 0.21).The preexisting rotational angle was significantly adjusted (overall, 11.1°). Depending on rotation direction, preoperative 21.7° to postoperative 12.1° in 27 patients of convergent group and preoperative −5.0° to postoperative 8.3° in 19 patients of divergent group were achieved.Conclusions: The rotation from proximal phalanx fractures could be corrected with anatomic reduction by open reduction. Our results showed that open reduction and rigid internal fixation after physical examination for acute proximal phalanx fractures accompanied by rotational malalignment could achieve good clinical results.
Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup
Authors: Pirker Christine , Bilecz Agnes , Grusch Michael , Mohr Thomas , Heidenreich Barbara , Laszlo Viktoria , Stockhammer Paul , Lötsch-Gojo Daniela , Gojo Johannes , Gabler Lisa , Spiegl-Kreinecker Sabine , Dome Balazs , Steindl Ariane , Klikovits Thomas , Hoda Mir Alireza , Jakopovic Marko , Samarzija Miroslav , Mohorcic Katja , Kern Izidor , Kiesel Barbara , Brcic Luka , Oberndorfer Felicitas , Müllauer Leonhard , Klepetko Walter , Schmidt Wolfgang M. , Kumar Rajiv , Hegedus Balazs , Berger Walter 
Published: April 2020

Abstract

Purpose:
Human malignant pleural mesothelioma (MPM) is characterized by dismal prognosis. Consequently, dissection of molecular mechanisms driving malignancy is of key importance. Here we investigate whether activating mutations in the telomerase reverse transcriptase (TERT) gene promoter are present in MPM and associated with disease progression, cell immortalization, and genomic alteration patterns.

Experimental Design:
TERT promoters were sequenced in 182 MPM samples and compared with clinicopathologic characteristics. Surgical specimens from 45 patients with MPM were tested for in vitro immortalization. The respective MPM cell models (N = 22) were analyzed by array comparative genomic hybridization, gene expression profiling, exome sequencing as well as TRAP, telomere length, and luciferase promoter assays.

Results:
TERT promoter mutations were detected in 19 of 182 (10.4%) MPM cases and significantly associated with advanced disease and nonepithelioid histology. Mutations independently predicted shorter overall survival in both histologic MPM subtypes. Moreover, 9 of 9 (100%) mutated but only 13 of 36 (36.1%) wild-type samples formed immortalized cell lines. TERT promoter mutations were associated with enforced promoter activity and TERT mRNA expression, while neither telomerase activity nor telomere lengths were significantly altered. TERT promoter–mutated MPM cases exhibited distinctly reduced chromosomal alterations and specific mutation patterns. While BAP1 mutations/deletions were exclusive with TERT promoter mutations, homozygous deletions at the RBFOX1 and the GSTT1 loci were clearly enriched in mutated cases.

Conclusions:
TERT promoter mutations independently predict a dismal course of disease in human MPM. The altered genomic aberration pattern indicates that TERT promoter mutations identify a novel, highly aggressive MPM subtype presumably based on a specific malignant transformation process.
Polygenic Hyperlipidemias and Coronary Artery Disease Risk
Authors: Ripatti Pietari , Rämö Joel T. , Mars Nina J. , Fu Yu , Lin Jake , Söderlund Sanni , Benner Christian , Surakka Ida , Kiiskinen Tuomo , Havulinna Aki S. , Palta Priit , Freimer Nelson B. , Widén Elisabeth , Salomaa Veikko , Tukiainen Taru , Pirinen Matti , Palotie Aarno , Taskinen Marja-Riitta , Ripatti Samuli ,   on behalf of FinnGen†
Published: April 2020

Background:
Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what extent a high polygenic load of a large number of LDL (low-density lipoprotein) cholesterol (LDL-C) or triglyceride (TG)-increasing variants associates with increased CAD risk.

Methods:
We derived polygenic risk scores (PRSs) with ≈6M variants separately for LDL-C and TG with weights from a UK Biobank–based genome-wide association study with ≈324K samples. We evaluated the impact of polygenic hypercholesterolemia and hypertriglyceridemia to lipid levels in 27 039 individuals from the National FINRISK Study (FINRISK) cohort and to CAD risk in 135 638 individuals (13 753 CAD cases) from the FinnGen project (FinnGen).

Results:
In FINRISK, median LDL-C was 3.39 (95% CI, 3.38–3.40) mmol/L, and it ranged from 2.87 (95% CI, 2.82–2.94) to 3.78 (95% CI, 3.71–3.83) mmol/L between the lowest and highest 5% of the LDL-C PRS distribution. Median TG was 1.19 (95% CI, 1.18–1.20) mmol/L, ranging from 0.97 (95% CI, 0.94–1.00) to 1.55 (95% CI, 1.48–1.61) mmol/L with the TG PRS. In FinnGen, comparing the highest 5% of the PRS to the lowest 95%, CAD odds ratio was 1.36 (95% CI, 1.24–1.49) for the LDL-C PRS and 1.31 (95% CI, 1.19–1.43) for the TG PRS. These estimates were only slightly attenuated when adjusting for a CAD PRS (odds ratio, 1.26 [95% CI, 1.16–1.38] for LDL-C and 1.24 [95% CI, 1.13–1.36] for TG PRS).

Conclusions:
The CAD risk associated with a high polygenic load for lipid-increasing variants was proportional to their impact on lipid levels and partially overlapping with a CAD PRS. In contrast with a PRS for CAD, the lipid PRSs point to known and directly modifiable risk factors providing additional guidance for clinical translation.
Association Between Atrial Fibrillation and Cognitive Impairment in Individuals With Prior Stroke
Authors: Kokkinidis Damianos G. , Zareifopoulos Nikos , Theochari Christina A. , Arfaras-Melainis Angelos , Papanastasiou Christos A. , Uppal Dipan , Giannakoulas George , Kalogeropoulos Andreas P. , Fontes Joao Daniel T. 
Published: April 2020

Background and Purpose—
Atrial fibrillation (AF) is the most common chronic arrhythmia. Dementia and cognitive impairment (CI) are major burdens to public health. The prevalence of all 3 entities is projected to increase due to population aging. Previous reports have linked AF with a higher risk of CI and dementia in patients without prior stroke. Stroke is known to increase the risk for dementia and CI. It is unclear if AF in patients with history of stroke can further increase the risk for dementia or CI. Our purpose was to evaluate the impact of AF on risk for dementia or CI among patients with history of stroke.

Methods—
Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines were followed. Pubmed, Scopus, and Cochrane central were searched. The outcomes of interest were dementia, CI, and the composite end point of dementia or CI. A random-effect model meta-analysis was performed. Meta-regression analysis was also performed. Publication bias was assessed with the Egger test and with funnel plots.

Results—
Fourteen studies and 14 360 patients (1363 with AF) were included in the meta-analysis. In the meta-analysis of adjusted odds ratio, AF was associated with increased risk of CI (odds ratio, 1.60 [95% CI, 1.20–2.14]), dementia (odds ratio, 3.11 [95% CI, 2.05–4.73]), and the composite end point of CI or dementia (odds ratio, 2.26 [95% CI, 1.61–3.19]). The heterogeneity for the composite end point of dementia or CI was moderate (adjusted analysis). The heterogeneity for the analysis of the end point of CI only was substantial in the unadjusted analysis and moderate in the adjusted analysis. The heterogeneity for the end point of dementia only was moderate in the unadjusted analysis and zero in the adjusted analysis.

Conclusions—
Our results indicate that an association between AF and CI or dementia is patients with prior strokes is possible given the persistent positive associations we noticed in the unadjusted and adjusted analyses. The heterogeneity levels limit the certainty of our findings.
Translesional Pressure Gradient Alters Relationship Between Blood Pressure and Recurrent Stroke in Intracranial Stenosis
Authors: Feng Xueyan , Chan Ka Lung , Lan Linfang , Abrigo Jill , Ip Vincent H.L. , Soo Yannie O.Y. , Leung Thomas W. , Leng Xinyi 
Published: April 2020

Background and Purpose—
There is debate over an optimal systolic blood pressure (SBP) in secondary stroke prevention of patients with symptomatic intracranial atherosclerotic stenosis (sICAS). We investigated whether translesional pressure gradient across sICAS would alter the relationship between SBP and risk of recurrent stroke in such patients.

Methods—

We recruited patients with sICAS (50%–99% stenosis) confirmed in computed tomography angiography. We simulated blood flow across sICAS with computed tomography angiography-based computational fluid dynamics models. Translesional pressure ratio (PR=Pressure
post-stenotic
/Pressure
pre-stenotic
) was calculated in each case. Pressure ratio (PR) ≤ median was defined as low PR, indicating larger translesional pressure gradient across sICAS. All patients received optimal medical treatment. We investigated the interaction of translesional PR and mean SBP during follow-up (SBP
FU
) in determining the risk of the primary outcome, recurrent ischemic stroke in the same territory within 1 year.

Results—

Among 157 patients with sICAS, the median PR was 0.93. Multivariate Cox regression revealed significant PR-SBP
FU
interaction on the primary outcome (
P
=0.008): in patients with normal PR, risk of primary outcome significantly decreased with lower SBP
FU
(hazard ratio for 10 mm Hg decrement =0.46;
P
=0.018); however, in those with low PR, SBP
FU
≤130 mm Hg was associated with significantly increased risk of primary outcome, compared with 130<SBP
FU
<150 mm Hg (hazard ratio=5.08;
P
=0.043).

Conclusions—
Low SBP level may be associated with increased risk of stroke recurrence in patients with sICAS with a large translesional pressure gradient. Translesional PR by computational fluid dynamics models may yield a promising indicator to guide more individualized blood pressure management in patients with sICAS, warranting future studies.
Evaluation of Leading Modes of Climate Variability in the CMIP Archives
Authors: Fasullo John T. , Phillips A. S. , Deser C. 
Published: April 2020

AbstractThe adequate simulation of internal climate variability is key for our understanding of climate as it underpins efforts to attribute historical events, predict on seasonal and decadal time scales, and isolate the effects of climate change. Here the skill of models in reproducing observed modes of climate variability is assessed, both across and within the CMIP3, CMIP5, and CMIP6 archives, in order to document model capabilities, progress across ensembles, and persisting biases. A focus is given to the well-observed tropical and extratropical modes that exhibit small intrinsic variability relative to model structural uncertainty. These include El Niño–Southern Oscillation (ENSO), the Pacific decadal oscillation (PDO), the North Atlantic Oscillation (NAO), and the northern and southern annular modes (NAM and SAM). Significant improvements are identified in models’ representation of many modes. Canonical biases, which involve both amplitudes and patterns, are generally reduced across model generations. For example, biases in ENSO-related equatorial Pacific sea surface temperature, which extend too far westward, and associated atmospheric teleconnections, which are too weak, are reduced. Stronger tropical expression of the PDO in successive CMIP generations has characterized their improvement, with some CMIP6 models generating patterns that lie within the range of observed estimates. For the NAO, NAM, and SAM, pattern correlations with observations are generally higher than for other modes and slight improvements are identified across successive model generations. For ENSO and PDO spectra and extratropical modes, changes are small compared to internal variability, precluding definitive statements regarding improvement.
Energetics of the Deep Gulf of Mexico
Authors: Maslo Aljaz , Azevedo Correia de Souza João Marcos , Pardo Julio Sheinbaum 
Published: April 2020

AbstractThe evaluation of the ocean energy balance is crucial for improving the fundamental understanding of the mechanisms sustaining ocean circulation. Based on the outputs of the ROMS ocean model, the energy cycle, eddy–mean flow interactions, and energy pathways of the deep Gulf of Mexico (GoM) have been investigated in this study. The theoretical framework for the analysis is based on the energy equations for the time-mean and time-varying flow, where some of the terms were split into their horizontal and vertical components to monitor the energy pathways. Of the energy maintaining deep kinetic energy (KE), approximately 75% is transferred from the upper layer to the deep layer by vertical pressure work (PW), about 6% by the horizontal PW through the Yucatan and Florida straits, and ~19% is generated through the processes related to baroclinic instabilities. The mean circulation generates eddies in the upper layer, while eddies drive mean circulation in the deep layer. Energy is transferred downward in the eastern and western part of the Gulf, upward in the deep western-central part, and a strong westward energy transport can be observed below 2000-m depth.
The Hurricane Harvey (2017) Texas Rainstorm: Synoptic Analysis and Sensitivity to Soil Moisture
Authors: Galarneau Thomas J. , Zeng Xubin 
Published: April 2020

Abstract
A synoptic analysis and soil moisture (SM) sensitivity experiment is conducted on the record-breaking rainstorm in Texas associated with Hurricane Harvey on 26–30 August 2017. The rainstorm occurred as the moist tropical air mass associated with Harvey was lifted along a frontogenetical near-surface coastal baroclinic zone beneath the equatorward entrance region of an upper-level jet streak. The weak steering winds in Harvey’s environment, allowing Harvey to remain nearly stationary, were associated with a deformation steering flow pattern characterized by a trough to the north and flanking ridges to the west and east. This pattern has occurred with other notable tropical cyclone rainstorms along the Gulf Coast, except in Harvey’s case it contributed to the collocation of deep tropical moisture and a persistent midlatitude lifting mechanism. Motivated by marked increases in SM during the rainstorm, a suite of six numerical simulations is used to test the sensitivity of the Harvey rainstorm (track, intensity, and rainfall) to varying SM. These simulations include dry, realistic, and wet SM conditions and an additional three runs with the initial SM held constant throughout the simulations. The results showed that track and prelandfall intensity were most sensitive to SM. Decreased SM resulted in the 1) development of an anticyclone in the southern plains that steered Harvey farther southwest in Texas, and 2) interruption in the intensification of Harvey in the Gulf of Mexico as dry air in the Yucatan Peninsula was entrained into Harvey’s circulation, contributing to a weaker system at landfall. Implications of these findings on the evolution of tropical systems are also discussed.