bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the use of Cannabinoid-based Medicine among older residential care recipients diagnosed with dementia: A study protocol for a double blind randomised cross-over trial
Authors: Timler Amanda , Bulsara Caroline , Bulsara Max , Vickery Alistair , Smith Jill , Codde Jim 
Published: December 2019

Abstract
Background: Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65-years and above. More effective ways to manage dementia symptoms are needed as current treatment options (anti-depressant and antipsychotic) can be ineffective and associated with substantial side-effects, including increased rate of mortality. Cannabinoid-based medicines (CBM) has shown to inhibit some symptoms associated with dementia and the adverse effects are often minimal, yet little research has explored the use of CBM among this population. Aim. To monitor the safety of a purified dose of CBM oil (3:2 THC:CBD) on behaviour symptoms, Quality of life (QOL), and discomfort caused by pain. Methods/Design: We will carry out an 18-week randomised, double-blinded, crossover trial that consists of a 2-week eligibility period, two, 6-week treatment cycles and two, 2-week washout periods (between both cycles, and after the second treatment cycle). We aim to recruit 50 participants with dementia who are living in residential aged-care facilities. The participants will be randomised into two groups, and receive a dose of either CBM oil or placebo for the first treatment cycle and receive the opposite medication for the second. The Neuropsychiatric Inventory Questionnaire, Cohen Mansfield Agitation Inventor, Quality of Life-Alzheimer’s Disease questionnaire, and the Abbey Pain Scale will be collected on seven occasions, and completed by the participants, aged-care staff, and nominated next of kin or family member. The participant’s heart rate and blood pressure will be monitored weekly and their body composition and weight will be monitored fortnightly by a research nurse to assess individual dose response and frailty. In addition, pre- and post-surveys will be administered to aged-care staff and family members to understand their perceptions towards CBM, and to inform proposed focus groups consisting of the aged care staff and next of kin. Discussion: The study design has been informed by medical professionals and key stakeholders including those working in the residential aged-care industry to ensure patient safety, collection of non-invasive measures, and methodological rigor and study feasibility.
Educação Permanente: Caminho para Sistematização da Assistência de Enfermagem em Saúde Mental
Authors: Costa da Matta Xavier Simone , Cortez Elaine Antunes 
Published: December 2019

Objetiva informar a pesquisa para implementar espaço permanente de reflexão-ação-reflexão sobre Sistematização da Assistência de Enfermagem com elaboração coletiva de um calendário de atividades utilizando as Metodologias Ativas, onde serão apresentados e discutidos elementos orientadores para elaboração da assistência de enfermagem e suas etapas a serem preenchidas em conjunto para (re)orientar o projeto terapêutico singular multidisciplinar. Apresenta como objetivos específicos a identificação do modelo de assistência de enfermagem existente no Centro de Atenção Psicossocial III na zona sul do Rio de Janeiro e investigar, junto a equipe de enfermagem, os limites e as possibilidades para implementação da Sistematização da Assistência de Enfermagem em Saúde Mental neste serviço. Metodologia: pesquisa qualitativa descritiva exploratória, com aplicação de questionário semi-estruturado autoaplicado e oficinas com Metodologia do Arco de Maguerez, com os 18 profissionais de enfermagem da unidade pesquisada. Para análise será utilizada a análise de conteúdo de Bardin e a Metodologia da Problematização. Resultados: Propõe incorporar a Educação Permanente ao cotidiano para implementação da SAE em Saúde Mental, como norteador do cuidado. Considerações: Acredita ser instrumento orientador da prática cotidiana do cuidado e facilitador da comunicação entre profissionais, usuários e familiares, respeitando a transparência do SUS. E contribuir academicamente ao incorporar, com qualidade, as produções científicas a respeito e no processo de (re)construção do saber no manejo das práticas profissionais. Diminuindo a dicotomia entre o saber e fazer, além da compreensão de um novo sujeito, ativo participa continuamente da construção do processo do cuidar.
O ensino da Vigilância em Saúde na graduação em Enfermagem
Authors: Penna Fabíola Braz , Cardoso Mourão Lúcia , Almeida Ana Clementina Vieira de , Leite Isabel Cristina de Moura , Teixeira Patrícia Ribeiro da Silva Maia , Pacheco Carlos Henrique 
Published: December 2019

Objetivos: analisar o ensino da prática profissional baseada no modelo tecnoassistencial orientado pelos conceitos da Vigilância em Saúde no currículo da graduação em Enfermagem de uma universidade privada na região serrana no Estado do Rio de Janeiro e identificar as competências e as habilidades enfatizadas no ensino da prática profissional embasada na Vigilância em Saúde. Metodologia: pesquisa intervenção, com abordagem qualitativa, utilizando o referencial teórico-metodológico da Análise Institucional, em sua modalidade Socioclínica Institucional, a ser desenvolvida em uma universidade privada da região serrana do Estado do Rio de Janeiro com os docentes da graduação da Enfermagem. A produção de dados acontecerá nos encontros Socioclínicos Institucionais agendados previamente. Serão realizados registros no diário de pesquisa pela pesquisadora. Resultados esperados: promover a discussão, a reflexão e transformações nas práticas docentes e do currículo da graduação em Enfermagem da universidade, contribuindo para uma formação em Vigilância em Saúde voltada para o enfrentamento das emergências em saúde de forma eficaz. A pesquisa foi submetida à apreciação do Comitê de Ética em Pesquisa da Universidade Federal Fluminense.
Palavras-chave: Emergências. Saúde Pública. Ensino de Enfermagem. Vigilância em Saúde Pública.
DTIP: A Comparative Analytical Framework for Chemogenomic Drugtarget Interactions Prediction
Authors: Haddadi Faraneh , Kayvanpour Mohammad Reza 
Published: December 2019

Background:
Prediction of drug-target interactions is an essential step in drug discovery.
Given drug-target interactions network, the objective of this task is to predict probable missing
edges from known interactions. Computationally predicting drug-target interactions is an appropriate
alternative for the time-consuming and costly experimental process of drug-target interaction
prediction. A large number of computational methods for solving this problem have been
proposed in recent years.

Objective:
In recent years, several review articles have been published in the field of drug-target
interactions prediction. Compared to other review articles, this paper includes a qualitative analysis
in the form of a framework, a drug-target interactions prediction (DTIP) framework.

Methods:
The framework consists of three sections. Initially, a classification has been presented
for drug-target interactions prediction methods based on the link prediction approaches used in
these methods. Secondly, general evaluation criteria have been introduced for analyzing approaches.
Finally, a qualitative comparison is made between each approach in terms of their advantages
and disadvantages.

Results:
By providing a new classification of the drug-target interactions prediction approaches
and comparing them with the proposed evaluation criteria, this framework provides a convenient
and efficient way to select and compare the methods. Moreover, using the framework, we can improve
these techniques further.

Conclusion:
This paper provides a study to select, compare, and improve chemogenomic drugtarget
interactions prediction methods. To this aim, an analytical framework is presented.
Development of a Quantitative NMR Method for Direct and Simultaneous Determination of Four Flavonoids in Scutellaria baicalensis georgi Extracts
Authors: Su Feng , Chen Ji-Peng , Zhu Pei-Xi , Wang Yi-Fan , Liang Xian-Rui , Su Wei-Ke 
Published: December 2019

Introduction:
Scutellaria Baicalensis Georgi (SBG), a Traditional Chinese Medicine (TCM)
used for the treatment of antiviral therapy, contains many flavonoids.

Materials and Methods:
A simple, fast and accurate 1H quantitative nuclear magnetic resonance (1HqNMR)
method was established for simultaneously determination of four flavonoids (Baicalin, Baicalein,
Wogonin and Wogonoside) in SBG extract by using 3,4,5-trichloropyridine as an internal
standard (IS). All the NMR determination work was performed at 308 K on an NMR sample tube inserted
with a co-axial tube. The NMR sample tube was added with the sample (SBG extract and IS), the
co-axial insert tube was added with D2O. Quantification of four flavonoids was carried out by calculating
the relative peak area ratio of the selected proton signals from the target compounds and the IS.

Results:
The validated 1H-qNMR method was successfully used to determine the four flavonoids in 9
batches of SBG from different origins and the results were in good accordance with those obtained
from HPLC.

Conclusion:
The established 1H-qNMR method could be used as a powerful tool for the quality control of
SBG from different sources and had potential in the quantification of main components from other TCMs.
Inhibition of Mycelial Growth of Rhizoctonia Solani by Chitosan in vitro and in vivo
Authors: Mohammed Sabah R. , Zeitar Elsayed M. , Eskov Ivan D. 
Published: December 2019

Objective:Evaluate the antifungal effect of chitosan againstRhizoctonia solani in vitroand the possible mechanisms of its induced activity in potato tubers to control black scurf disease.Methods:Thein vitroinfluence of chitosan at different concentrations on mycelial growth ofR. solaniwas tested by using the poisoned food technique in PDA medium. The effect of these concentrations on the development of lesion diameters in tubers inoculated withR. solanimycelium was assayed for 30 days. The concentration that showed the greatest inhibitory effect on lesion diameters was tested to assess the induced activity of defense-related enzymes in the infected tubers.Results:In the poisoned food technique, chitosan at 1% completely inhibited the growth ofR. solanimycelium.In vivotests showed that chitosan treatment at 0.5% effectively controlled the black scurf in tubers inoculated withR. solanimycelium. Chitosan increased the activities of defense-related enzymes such as Peroxidase (POD), Polyphenol Oxidase (PPO) and Phenylalanine Ammonia-lyase (PAL) in treated tubers of tested cultivars.Conclusion:This work demonstrated that chitosan directly inhibited the growth ofR. solani, and potentially elicited defense reaction in potato tubers.
Effect of Psychological Empowerment on Nurses Burnout
Authors: Permarupan P. Yukthamarani , Mamun Abdullah Al , Samy Naresh Kumar , Saufi Roselina Ahmad , Hayat Naeem 
Published: December 2019

Objective:The health industry needs motivated and satisfied nursing staff to provide quality health services to medical tourists, as well as in other sectors. This study aimed to examine the effects of psychological empowerment on the dimensions of burnout among the Malaysian nursing staff, as well as exploring the role of age, gender, experience, and marital status on the perception of burnout dimensions.Methods:This survey used a sample of 432 nursing staff, using measures of the perception of empowerment and comparing variables with another measure of burnout, collectedviaa self-reported questionnaire. Data were analyzed using PLS-SEM. Moreover, the group analysis in PLS-SEM estimated the differences among the nursing staff’s perception of psychological empowerment on burnout factors.Results:The findings reveal that psychological empowerment reduces the impact of burnout symptoms. Moreover, gender and age are different for depersonalization by the perception of psychological empowerment among the nursing staff in Malaysia. The Malaysian nursing staff’s marital status influences the relationships between psychological empowerment and depersonalization, as well as emotional exhaustion and personal unfulfillment. Moreover, the experience of the nursing staff influences the perception of personal unfulfillment in a significant manner.Conclusion:This study offered important managerial implications, such as considering the nursing staff’s needs according to age, gender, material status, and working experience to address burnout issues of emotional exhaustion, depersonalization, and personal unfulfillment. Moreover, it is important to note that the different factors of burnout are perceived differently by the nursing staff based on their attributes. There is a need to utilize the provision of psychological empowerment needs.
Vibration Tests and Structural Identification of the Bell Tower of Palermo Cathedral
Authors: Cavaleri Liborio , Ferrotto Marco Filippo , Di Trapani Fabio , Vicentini Alessandro 
Published: December 2019

Background:
The recent seismic events in Italy have underlined once more the need for seismic prevention for historic constructions of architectural interest and in general, the building heritage. During the above-mentioned earthquakes, different masonry monumental buildings have been lost due to the intrinsic vulnerability and ageing that reduced the structural member strength. This has made the community understand more that prevention is a necessary choice for the protection of monuments.

Objective:
The paper aims at demonstrating a strategy of investigation providing the possibility of health judgment, identifying a computational model for the assessment of structural capacity under service and exceptional loading like/due to high-intensity earthquakes. Considering its cost, the proposed approach is applicable only for monumental buildings. In detail, activity regarding the Bell Tower of the Palermo Cathedral is described. This investigation is framed in a huge campaign aimed at assessing the health of monuments in Palermo and their capacity to resist expected seismic actions.

Methods:
The process of the dynamic identification of the Bell Tower of Palermo Cathedral is discussed starting from the measurement of the response by high sensitivity seismometers and the analysis of the response signals. Then, the formulation of a Finite Element (FE) model of the tower is proposed after the identification of the main modal shapes. Once the Finite Element (FE) model was assessed, it was possible to evaluate the Bell Tower safety level in service and faced with exceptional loads.

Results:
The structural signals recorded along the height of the tower were analyzed to recognize the variation of the frequency content varying the external environmental loads. The signals were processed to obtain the experimental modal shapes. An FE model was defined whose mechanical parameters were successfully calibrated to give the experimental modal shapes.

Conclusion:
The analysis of the response signals made it possible to identify the actual behavior of the structure and its compatibility with the service loads. Further, an effective structural model of the Bell Tower of Palermo Cathedral was possible for assessing its capacity level.
A Review of Research on the State-of-Charge Estimation Methods for Electric Vehicle Battery
Authors: Zhang Mingyue , Fan Xiaobin , Gan Jing , Song Zeng , Zhao Bin 
Published: December 2019

Background:
Battery technology has been one of the bottlenecks in electric cars. Whether it is in theory or in practice, the research on battery management is extremely important, especially for battery state-of-charge estimation. In fact, the battery has a strong time change and non-linear properties, which are extremely complex systems. Therefore, accurate estimating the state of charge is a challenging thing.

Objective:
The study aims to report the latest progress in the studies of the state-of-charge estimation methods for electric vehicle battery.

Methods:
This paper reviews various representative patents and papers related to the state of charge estimation methods for electric vehicle battery. According to their theoretical and experimental characteristics, the estimation methods were classified into three groups: the traditional estimation algorithm based on the battery experiment, the estimation algorithm based on modern control theory and other estimation algorithm based on the innovative ideas, especially focusing on the algorithms based on control theory.

Results:
The advantages and disadvantages, current and future developments of the state-of-charge estimation methods are finally provided and discussed.

Conclusion:
Each kind of state of charge estimation method has its own characteristics, suitable for different occasions. At present, algorithms based on control theory, especially intelligent algorithms, are the focus of research in this field. The future development direction is to establish rich database, improve hardware technology, put up with more perfect battery model, and give full play to the advantages of each algorithm.
On Transfemoral Prosthetic Knee Design for Natural Human Knee Motion
Authors: Lee Wen-Tzong , Russell Kevin , Sodhi Raj S. 
Published: December 2019

Background:
A transfemoral prosthetic knee is an artificial knee used by above-the-knee
amputees. There are two major categories of transfemoral prosthetic knee designs: pin joint-based and
polycentric designs. While pin joint-based knee designs only allow pure rotation of the knee, polycentric
knee designs allow a combination of rotational and translational knee motion which is exhibited in
natural knee motion.

Objective:
This work presents both the recently-patented design process and the resulting design of a
polycentric transfemoral prosthetic knee that approximates natural spatial human knee motion during
flexion and extension.

Methods:
The design process includes tibial motion acquisition, Revolute-Revolute-Spherical-Spherical
linkage (or RRSS) motion generation, RRSS linkage axode generation and circle fitting. The polycentric
transfemoral prosthetic knee design produced from this process includes a gear joint with a specific
spatial orientation to approximate natural spatial human knee motion.

Results:
Using the design process, a polycentric transfemoral prosthetic knee was designed to replicate
a group of five tibial positions over 37.5° of knee flexion (the amount of knee flexion in a standard
human gait cycle) with a minimal structural error.

Conclusion:
The circular gear-based knee design accurately replicated natural spatial knee motion over
the tibial position data given for a standard human gait cycle. The knee design method must be implemented
over a broader sampling of tibial position data to determine if a circular gear-based knee design
is consistently accurate.
Het officiële taalgebruik in Vlaanderen in de negentiende eeuw
Authors: Wils Lode 
Published: December 2019

De bijdrage van Lode Wils beschrijft de wettelijke regeling van het taalgebruik in het openbaar in het Verenigd Koninkrijk der Nederlanden (1815-1830) en het Koninkrijk België (tot 1900). In tegenstelling tot de dwingende taalregeling sinds 1823, werd in 1830 de vrijheid van taalgebruik ingevoerd voor provincie- en gemeentebesturen, rechters en notarissen. De centrale overheid bevorderde wel het officiële gebruik van het Frans, vooral onder liberale regeringen. Vanaf 1884, onder een katholieke regering, nam het gebruik van het Nederlands toe.Het artikel bevat tevens een kritiek van de sociolinguistische publicaties van Roland Willemyns en zijn team.
________The official use of language in Flanders during the nineteenth centuryThe contribution by Lode Wils describes the legal regulations for the use of language in public in the United Kingdom of the Netherlands (1815-1830) and the Kingdom of Belgium (until 1900). In contradiction to the obligatory language regulation that had been in force from 1823, 1830 saw the introduction of freedom of the use of language for provincial and municipal councils, judges and notaries. However, the central authorities did promote the official use of French, in particular during liberal governments. From 1884 during a Catholic government the use of Dutch increased.The article also includes a critical review of the socio-linguistic publications by Roland Willemyns and his team.
De autobiografie van Pieter Geyl
Authors: Wils Lode 
Published: December 2019

De Nederlandse historicus Pieter Geyl (1887-1966) was tijdens de tussenoorlogse periode de schepper van een ’Groot-Nederlandse geschiedschrijving’. Die had als doel de Histoire de Belgique van Henri Pirenne te discrediteren, hoewel Geyl binnenskamers erkende dat zijn Geschiedenis van de Nederlandche Stam een 'aftreksel' was van Pirennes werk. De lastercampagne tegen Pirenne was een onderdeel van Geyls völkische Groot-Nederlandse irredenta, om België te scheuren en de Nederlandstalige helft ervan, Vlaanderen, bij Nederland te annexeren. Dit werd vanaf 1975 aangetoond aan de hand van Geyls gepubliceerde briefwisseling, maar eerlingen van Geyl hebben dat met verontwaardiging ontkend. De publicatie van zijn autobiografie zou de ogen zelfs van blinden moeten openen.________The autobiography of Pieter Geyl: Self assurance and candourThe Dutch historian Pieter Geyl (1887-1966) created a ‘Greater Netherlands historiography’ during the interbellum period. Its objective was to discredit the Histoire de Belgique by Henri Pirenne, although Geyl admitted privately that his Geschiedenis van de Nederlandse Stam was a ‘rehash’ of Pirenne’s work. The libel campaign against Pirenne was a part of Geyl’s völkische (populist) Greater Netherlands irredenta, to split Belgium and to annex its Dutch speaking half, Flanders, to the Netherlands. From 1975 this was demonstrated on the basis of Geyl’s published exchange of letters, but his students denied this with great indignation. The publication of his autobiography ought to open the eyes of even those who cannot see.