bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Perioperative Risk Factors for Deep Vein Thrombosis in Patients With Femoral and Pelvic Fractures
Authors: Wu Linqin , Cheng Bo 
Published: September 2020

Abstract
Objective: Clinical characteristics, anticoagulant protocols and risk factors of deep Vein thrombosis (DVT) in patients with femoral and pelvic fractures were analyzed throughout the perioperative period to provide references for early identification and optimization of risk factors.Methods: This was a retrospective study. A total of 569 patients undergoing surgery of femoral and pelvic fractures from May 2018 to December 2019 were included. The Clinical data including general conditions,trauma, surgery,anticoagulant protocols and laboratory indexes were collected.According to the results of deep vein Doppler ultrasonography of the lower extremities, the patients were divided into non-DVT group and DVT group.Univariate analysis and multivariate logistic regression analysis were used to identify the independent risk factors of preoperative and postoperative DVT.Results: The incidence of DVT was 40.25%, PE was 1.93%, and preoperative DVT was 26.71%,which was higher than the incidence of postoperative DVT of 17.22%. Most of them were thrombus on the affected side (60.26%) and distal thrombus (81.66%).The average time of DVT formation was 6.55±0.47 days after trauma and 6.67±0.48 days after surgery. Chronic obstructive pulmonary disease(COPD), anemia, hypoproteinemia, non-anticoagulation before surgery, delayed anticoagulation after trauma and admission, high energy trauma, multiple injuries, drinking history, and advanced age were independent risk factors for perioperative DVT.The increased level of fibrinogen degradation products was an independent risk factor for preoperative DVT. These risk factors were identified to be independently associated with postoperative DVT, including intraoperative blood transfusion, postoperative blood transfusion, pulmonary infection, preoperative non-anticoagulation, postoperative delayed anticoagulation, preoperative waiting time > 7d, operative time > 2h, c-reactive protein, fibrinogen level, platelet count 1 day after surgery, c-reactive protein, fibrinogen, and hemoglobin levels 3 days after surgery, comminuted fracture.Conclusions: At present, anticoagulation and other DVT prevention and treatment programs have not changed the current situation that the incidence of DVT is still high. Through the analysis of the risk factors of DVT throughout the perioperative period, optimizing the perioperative blood transfusion, preoperative lung disease, hypoproteinemia, anemia, inflammation, etc., and surgery as soon as possible after trauma may further reduce its incidence.
A Cross-sectional Online Survey on Knowledge, Attitude, and Perception of COVID-19 among Ghanaians
Authors: Akuoko Ebenezer , Alando Cyril 
Published: September 2020

Abstract
This study examined knowledge, attitude, and perceptions of COVID-19 among Ghanaians. A cross-sectional survey was conducted using Google forms to recruit 503 participants over six weeks. We performed descriptive statistical analysis, and presented results in tables/charts. From the results, 66.4% of respondents depended on social media for COVID-19 related information, and 59.8% mostly heard/read about preventive measures in all COVID-19 information heard/read. Knowledge was adequate, but with noticeable gaps. Attitude was generally positive, with 84.1% willing to accept reintegration of treated COVID-19 patients. Perceptions were healthy, with only 3.8% perceiving insusceptibility. We conclude that these findings contribute significantly to the literature on COVID-19 in Ghana. We recommend the continuous use of social media by the Government of Ghana and relevant stakeholders for COVID-19 communications, and further research in the general population for evidence based COVID-19 prevention interventions in Ghana.
Genome-wide Association Study-based Identification Genes Influencing Agronomic Traits in Rice (Oryza Sativa L.)
Authors: wang aijun , Shu Xinyue , Jiang yuqi , Ma Li , jia xiaomei , ye xiaoying , deng qiming , Li shuangcheng , Wang shiquan , zhu jun , liang yueyang , zou ting , Wang Linxia , zhu jianqing , Li Ping , Zheng Aiping 
Published: September 2020

Abstract
BackgroundRice (Oryza sativa L.) is one of the most important cereal crops, providing the daily dietary intake for approximately 50% of the global human population. To needs of the rapidly increasing human population worldwide, cultivation of rice varieties with high yield and quality, more genes or QTLs association with yield traits are required.ResultsCurrently, correlations among different traits and gene interactions both affect the rice breeding. Here, we re-sequenced 259 rice accessions, generating 1, 371.65 Gb of raw data. Furthermore, we performed genome-wide association studies (GWAS) on 13 agronomic traits using 2.8 million single nucleotide polymorphisms (SNPs) characterized in 259 rice accessions. Phenotypic data and best linear unbiased prediction (BLUP) values of each of the 13 traits over two years of each trait were used for GWAS. The result showed that 816 SNP signals were significantly associated (−log10P≥5) with the 13 agronomic traits. We detected candidate genes related to target traits within 200 kb upstream and downstream of the associated SNP loci, based on linkage disequilibrium (LD) blocks in the whole rice genome. These candidate genes were further identified though haplotype block construction. ConclusionsThis study provides an important genomic resource and valuable new information for breeding high yielding breeding rice cultivars through genomic selection.
Investigating the Effect of COVID-19 on Spiritual Health and Stress of Pregnant Women
Authors: Nodoushan Reza Jafari , alimoradi Hadi , Nazari Mahsa 
Published: September 2020

Abstract
Introduction: Stress is one of the effective factors in the occurrence of negative effects during pregnancy that can cause adverse outcomes such as preterm delivery and reduced intrauterine growth of the fetus in pregnant women. Therefore, one of the serious concerns during the COVID-19 Pandemic is the physical health and mental health of pregnant women. This study aimed to evaluate the physical health status with the spiritual and mental health of pregnant women during the COVID-19 Pandemic.Methods: The study is a descriptive study in 2019-2020 and the samples were randomly selected from all pregnant women who referred to hospitals and private maternity centers before and during the COVID-19 Pandemic and performed all pregnancy and fetal health tests. It was performed on 560 pregnant female samples. The mental status of pregnant women was assessed using the DASS Spiritual Health and Stress Questionnaire. Data analysis was performed using SPSS statistical software (version 24).Result: The results of this study showed that preterm birth, height, weight and head circumference of babies and lungs and respiratory status of children with mental health and stress levels of pregnant women during the corona is significant compared to the previous of corona (p<0.05).Conclusion: Increasing stress and decreasing the mental health of pregnant women during COVID-19 Pandemic can increase the influencing factors in preterm delivery and unhealthy birth.
Comparison of Lipid Profiles Between Pediatric Living- and Deceased-Donor Liver Recipients
Authors: Dehghani Seyed Mohsen , Najafi Roya , Mehdizadegan Nima , Mohammadi Hamid , Edraki Mohammadreza 
Published: September 2020

Abstract
Background: Hyperlipidemia is very common after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is multifactorial, with different lipid profiles observed depending on the immunosuppressive agents administered and the presence of additional risk factors, such as obesity, diabetes mellitus and nutrition. The aim of the present study is to compare the lipid profile in liver transplant recipients from living-related and deceased donors.Methods: This is a retrospective cross-sectional study performed in Shiraz University of Medical Science between 2005 till 2018. Patients under 18 years old who received liver transplant were included in the study and divided in 2 groups who received from living-related and deceased donors and lipid profiles were compared between two groups.Results: 397 patients were included in the study, in the first group 234 received liver from deceased donor and in second group 161 from living-related donor. The mean TG and HDL level were 133 mg/dL and 46 mg/dL in the first group and 118 mg/dL and 54 mg/dL in the second group while the differences were statistically significant.Conclusion: Patients who received liver from a living-related donor have a significantly lower TG and higher HDL and a lower cardiovascular risk.
Extraordinary Hall Effect in Freestanding Oxide Heterostructures
Authors: Lim Z. S. , Zhou Z. , Han K. , Omar Ganesh Ji , Huang Z. , Zeng Shengwei , Ariando A. 
Published: September 2020

Abstract
Recently, Topological Hall Effect (THE) has been unravelled in various perovskite iridate, ruthenate and manganite interfaces, suggesting the presence of magnetic Skyrmion-like bubbles. Among the materials and sample structures investigated so far, the physical properties were not free from influences of substrates, which are templates for crystalline epitaxial growth. Additional contributions of Dzyaloshinskii-Moriya Interaction or Berry curvatures by the substrates may originate from several structural factors such as in-plane strain, octahedral rotation or terminations. In this report, we employ the water-soluble Sr3Al2O6 sacrificial buffer layer to prepare freestanding SrRuO3/SrIrO3 heterostructures with high-quality interfaces, and THE-like humps are observed up to 90 K. Analysing the Hall signal with the rotation of magnetic field direction suggests there are magnetically decoupled regions. This scheme also paves the way for several magnetic texture imaging techniques in transmission mode for future studies.
Rapid PCD Process Promotes Early Maturity in Weedy Rice (Oryza sativa L. f. spontanea)
Authors: Zhao Can , Xu Wenrong , Zhang Zheng , Meng Lingchao , Dai Weimin , Qiang Sheng , Song Xiaoling 
Published: September 2020

Abstract
Background: Shorter grain-filling period and rapid endosperm development contributes to early maturity in weedy rice (Oryza sativa L. f. spontanea). However, the differences in programmed cell death (PCD) process and anti-oxidative enzymes system in the caryopsis between weedy and cultivated rice are largely unexplored. Main Text: we selected four biotypes of weedy rice and associated cultivated rice (ACR, Oryza sativa) from different latitudes to conduct a common garden experiment. The difference of PCD process between weedy rice and ACR was compared by chemical staining, and the cell viability and nuclear morphometry of endosperm cells were observed by optical microscopy, and anti-oxidative enzymes activity were also measured during grain filling. We found that the PCD progress in weedy rice was more rapid and earlier than that in ACR. The percentage of degraded nuclei of weedy rice were 10%-83% higher than that of ACR. Endosperm cells in weedy rice lost cell viability 2-8 days earlier than that in ACR. The anti-oxidant enzymes activity of weedy rice were lower than that of ACR during grain filling. The ability of weedy rice to scavenge reactive oxygen species is weaker than that of ACR, which may contribute to the rapid PCD process in the endosperm cells of weedy rice. Conclusion: The rapid PCD process and weaker ability to scavenge reactive oxygen species in endosperm cells lead to the shorter grain-filling period of weedy rice.
Higher Dietary Inflammatory Index Scores are Associated with Increased Odds of Diabetic Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus: A Case–Control Study
Authors: Asadi Sara , Aminianfar Azadeh , Asadi Sasan , Yarizadeh Habib , Qorbani Mostafa , Mirzaei Khadijeh 
Published: September 2020

Abstract
Background: Diabetic sensorimotor polyneuropathy (DSPN) is a very common complication of diabetes. Dietary inflammatory score DII) has been associated with some diseases such as diabetes and cancers. Nonetheless, the association between DII and DSPN has not been explored. We aim to examine the association between DII and DSPN in a case-control study. Method: 185 subjects with DSPN and 185 controls were selected in this case-control study. 168-item validated food frequency questionnaire (FFQ) was used to assed dietary intake. DII was calculated based on FFQ. DSPN was diagnosed by Toronto clinical neuropathy score. Anthropometric measurements, physical activity, glycemic indices were measured. Information on social demographic data was collected by questionnaires.Result: After adjustment for age, sex, energy in model 1( p-trend< 0.001) (OR=0.25, 95% CI=0.13–0.49), participants at the highest quartile of DII had increased OR for DSPN additionally adjusted for physical activity, education, smokers, FBS, A1C and economic status in model 2 (OR=0.27, 95% CI=0.13–0.57) ( p-trend< 0.001) strengthened the relationship. The association was not altered substantially by further adjustment for BMI in model 3(OR=6.3, 95% CI=2.7–14.6) (p-trend < 0.001). Conclusion: Higher DII score was associated with increased risk of DSPN. Therefore, it is possible that a diet rich in anti-inflammatory nutrients and foods could improve and prevent DSPN.
Accurate recognition of colorectal cancer with semi-supervised deep learning on pathological images
Authors: Yu Gang , Xie Ting , Xu Chao , Shi Xing-Hua , Wu Chong , Meng Run-Qi , Meng Xiang-He , Wang Kuan-Song , Xiao Hong-Mei , Deng Hong-Wen 
Published: September 2020

Abstract
Background: The machine-assisted recognition of colorectal cancer has been mainly focused on supervised deep learning that suffer from a significant bottleneck of requiring massive labeled data. We hypothesize that semi-supervised deep learning leveraging a small number of labeled data can provide a powerful alternative strategy.Method: We proposed a semi-supervised model based on mean teacher that provide pathological predictions at both patch-level and patient-level. We demonstrated the general utility of the model utilizing 13,111 whole slide images from 8,803 subjects gathered from 13 centers. We compared our proposed method with the prevailing supervised learning and six pathologists.Results: with a small amount of labeled training patches (~3,150 labeled, ~40,950 unlabeled or ~6,300 labeled,~37,800 unlabeled), the semi-supervised model performed significantly better than the supervised model (AUC: 0.90 ± 0.06 vs. 0.84 ± 0.07, P value = 0.02 or AUC: 0.98 ± 0.01 vs 0.92 ± 0.04, P value = 0.0004). Moreover, we found no significant difference between the supervised model using massive ~44,100 labeled patches and the semi-supervised model (~6,300 labeled, ~37,800 unlabeled) at patch-level diagnoses (AUC: 0.98 ± 0.01 vs 0.987 ± 0.01, P value = 0.134) and patient-level diagnoses (average AUC: 97.40% vs. 97.96%, P value = 0.117) . Our model was close to human pathologists (average AUC: 97.17% vs. 96.91%).Conclusions: We reported that semi-supervised learning can achieve excellent performance through a multi-center study. We thus suggested that semi-supervised learning has great potentials to build artificial intelligence (AI) platforms, which will dramatically reduce the cost of labeled data and greatly facilitate the development and application of AI in medical sciences.
Principle and Control of Active Engine Mount Based on Magnetostrictive Actuator
Authors: Si Zhi-Yuan , BAI Xianxu , Qian Li-Jun , Chen Peng 
Published: September 2020

Abstract
The engine mount system affects the automobile NVH performance. Active mounts would achieve excellent vibration isolation and relative displacement control performance in a broad frequency bandwidth by outputting controlled force to the mounting system. The actuator and control method of the active mounts determine the system performance. In this paper, an active mount based on the smart material - Terfenol-D rod is proposed, which mainly includes three parts: rubber spring, magnetostrictive actuator (MA), and hydraulic amplification mechanism. Dynamic model of the active mount is correspondingly established. A state feedback control method based on x-LMS algorithm is proposed as well. Specifically, with the consideration of the unmeasurable state parameters in the active mounting system, an x-LMS state feedback controller with the system state as the reference signal is constructed by employing Sage-Husa Kalman filter to realize the state estimation of the active mounting system. Then a detailed analysis of the proposed control method is conducted, with deriving iterative formula of tap-weight vector. Sequentially, the problem of the dependence on the excitation signal in the x-LMS algorithm is addressed. The feasibility and capability of the proposed control method are verified and evaluated by simulation of a two-degree-of-freedom active mounting system.
The circBVES&nbsp;Acts as a Sponge of miR-145-5p&nbsp;to Promote Gastric Cancer Glycolysis and Progression Through Regulating HMGB3&nbsp;Expression
Authors: Jin Lu , He Zhiwei , Zhu Changhao , Xiao Guoliang , Yang Xianjin , Chen Xiao , Huang Wei 
Published: September 2020

Abstract
Background: CircRNA is a new type of non-coding RNA that has attracted much attention for involvement in the development and progression of various human diseases, especially cancer. The most reported role of circRNA in many tumors is ‘MiRNA sponge’. We aimed to investigate the role of circBVES in the proliferation and glycolysis of gastric cancer cells and its molecular mechanisms.Methods: In this study, higher CircBVES expression in gastric cancer tissues was detected by RNA sequencing. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the expression of CircBVES in gastric cancer tissues, and the relationship between the expression of CircBVES and prognosis was further analyzed. Then, the effects of CircBVES on the growth and glycolysis of gastric cancer cells were investigated through in vitro and in vivo functional experiments. The interaction between CircBVES and miR-145-5p was detected by bioinformatics analysis, luciferase activity assay and RNA immunoprecipitation.Results: We found that the expression of CircBVES in gastric cancer tissues was evidently up-regulated, and its level was closely correlated with the prognosis of patients with gastric cancer. Inhibition of CircBVES decreased cell proliferation and glycolysis in vitro. Low expression of CircBVES inhibited tumor growth in vivo. Mechanism analysis showed that CircBVES may serve as a competitive endogenous RNA of miR-145-5p to reduce the expression of miR-145-5p in gastric cancer cells, and relieve the repressive effect of miR-145-5p on target genes HMGB3 and cycle-related proteins CCNE1 and CDK2.Conclusions: Our results suggest that CircAGFG1 may promote the progress of gastric cancer through the CircBVES / miR-145-5p / HMGB3 axis, providing a new target for the treatment of gastric cancer cells.
3D Visualizations of Multiple Coronaviruses on Whole Genomes
Authors: Zhang Zhongwei , Duan Tingyan , Zheng Jeffrey 
Published: September 2020

Abstract
COVID-19 triggered by SARS-CoV-2 has become a common problem faced by people all over the world. With the development of bioinformatics and the breakthrough progress of gene technologies. It is a challenging topic to use genomic datasets for SARS-CoV-2 research. In this paper, a 3D visualization method is proposed to show the A9 module of the metagenomic analysis system MAS. Seven coronaviruses of genera were illustrated and briefly analyzed. Comparing the visualization results, various SARS-CoV-2 genomes were represented as 2D & 3D maps under different conditions. Through related specific projections, the characteristics of the coronavirus can be observed intuitively from the projection results to provide an effective viewpoint for studying viral genomes.
Geriatric rehabilitation and Covid-19 : a Case Report
Authors: Brika Marine , Bossu Maeva , Fautrelle Lilian , Mourey France , Kubicki Alexandre 
Published: September 2020

Abstract
Introduction : Covid-19 infection has particularly affected older adults. Clinical observations in this population highlight major respiratory impairment associated with development or aggravation of frailty state.Case Presentation : Mr P is a 93 years old frail patient, hospitalized after a COVID-19 infection. The assessment process of this patient has been supported by an innovative multi-systemic tool developed in view of the COVID-19 clinical consequences and a systemic evaluation of motor functions by the Frail BESTest. This process allowed presenting a mixed clinical picture associating an important respiratory distress (linked with the acute respiratory distress syndrome) and an evident motor frailty. The care plan was developed accordingly, and four assessment were done in the same manner until the return home of Mr PConclusion : This case report allows seeing holistically a COVID-19 clinical picture, showing the different axis of clinical reasoning to enhance the rehabilitation process. Furthermore, this case report illustrate the importance of rehabilitation in the Covid-19 context.
Clinical effectiveness of drugs in hospitalized patients with COVID-19: a systematic review and meta-analysis
Authors: Abeldaño Roberto Ariel , Coca Silvia Mercedes , Abeldaño Giuliana Florencia , Villoria Ruth Ana María González 
Published: September 2020

Abstract
Objective: The aim was to assess the clinical effectiveness of drugs used in hospitalized patients with COVID-19 infection.Method: We conducted a systematic review of randomized clinical trials assessing treatment with remdesivir, chloroquine, hydroxychloroquine, lopinavir, ritonavir, dexamethasone, and convalescent plasma, for hospitalized patients with a diagnosis of SARS-CoV-2 infection. The outcomes were mortality, clinical improvement, duration of ventilation, duration of oxygen support, duration of hospitalization), virological clearance, and severe adverse events.Results: A total of 48 studies were retrieved from the databases. Ten articles were finally included in the data extraction and qualitative synthesis of results. The meta-analysis suggests a benefit of dexamethasone versus standard care in the reduction of risk of mortality at day 28; and the clinical improvement at days 14 and 28 in patients treated with remdesivir.Conclusions: Dexamethasone would have a better result in hospitalized patients, especially in low-resources settings.Significance of results: The analysis of the main treatments proposed for hospitalized patients is of vital importance to reduce mortality in low-income countries; since the COVID-19 pandemic had an economic impact worldwide with the loss of jobs and economic decline in countries with scarce resources.