bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cortical 6-9 Hz Oscillation are a Reliable Biomarker of Persistent Pain in Rats
Authors: Furman Andrew J. , Raver Charles , Li Ying , Jenne Carleigh , Hoffman Kathleen , Seminowicz David A. , Keller Asaf 
Published: January 2020

AbstractNeural biomarkers of chronic pain offer a potential tool for improving the speed of diagnosis and delivery of treatment for this devastating disease. Here, we tested the hypothesis that pain states are associated with distinct changed in cortical brain waves. We induced neuropathic orofacial pain in female rats by chronic constriction injury of the infraorbital nerve (CCI-ION). In most animals, this resulted in lasting reductions in mechanical sensitivity thresholds, and in lasting increases in facial grimace scores. We recorded electrocortigraphy (ECoG) signals over the neocortex of these rats, before and after CCI-ION, and analyzed these signals with a novel, spectral modelling approach. Consistent with our hypothesis, power in the 6-9 Hz bandwidth of the ECoG was differentially modulated in animals displaying signs of chronic pain. Specifically, development of mechanical hypersensitivity correlated with adecreasein 6-9 Hz power. Furthermore, we show that changes in the power of this oscillation after injury, obtained at the individual animal level, provide a more sensitive marker of pain presence than do traditional between animal comparisons of post-injury oscillatory power. Identification of animals demonstrating chronic-pain behaviors was more accurate when estimates of post-injury oscillatory power were compared against each animal’s own pre-injury baseline than when compared against post-injury power estimates from animals not developing chronic pain. These results highlight the need for establishing individual-specific, “pain-free” baselines from which oscillation disturbances can be measured and which may constitute a reliable, low-cost approach not only for diagnosing chronic pain, but also for identifying individuals likely to transition from acute to chronic pain.
Host-induced silencing of theColletotrichum gloeosporioides conidial morphology 1gene (CgCOM1) confers resistance against Anthracnose disease in chilli and tomato
Authors: Mahto Binod Kumar , Singh Anjulata , Pareek Manish , Rajam Manchikatla V. , Dhar-Ray Swatismita , Reddy Pallavolu M. 
Published: January 2020

AbstractAnthracnose disease is caused by the ascomycetes fungal speciesColletotrichum,which is responsible for heavy yield losses in chilli and tomato worldwide. Conventionally, harmful pesticides are used to contain anthracnose disease with limited success. In this study, we assessed the potential of Host-Induced Gene Silencing (HIGS) approach to target theColletotrichum gloeosporioides COM1(CgCOM1) developmental gene involved in the fungal conidial and appressorium formation, to restrict fungal infection in chilli and tomato fruits. For this study, we have developed stable transgenic lines of chilli and tomato expressingCgCOM1-RNAi construct employingAgrobacterium-mediated transformation. Transgenic plants were characterized by molecular and gene expression analyses. Production of specificCgCOM1siRNA in transgenic chilli and tomato RNAi lines was confirmed by stem-loop RT-PCR. Fungal challenge assays on leaves and fruits showed that the transgenic lines were resistant to anthracnose disease-causingC. gloeosporioidesin comparison to wild type and empty-vector control plants. RT-qPCR analyses in transgenic lines revealed barely anyCgCOM1transcripts in the C.gloeosporioidesinfected tissues, indicating near complete silencing ofCgCOM1gene expression in the pathogen. Microscopic examination of theCg-challenged leaves of chilli-CgCOM1i lines revealed highly suppressed conidial germination, germ tube development, appressoria formation and mycelial growth ofC. gloeosporioides, resulting in reduced infection of plant tissues. These results demonstrated highly efficient use of HIGS in silencing the expression of essential fungal developmental genes to inhibit the growth of pathogenic fungi, thus providing a highly precise approach to arrest the spread of disease.
The relationship between the regulation of licit medications containing pseudoephedrine and the illicit methamphetamine market in Czechia and neighbouring countries
Authors: Petruzelka Benjamin 
Published: January 2020

Purpose
The purpose of this paper is to improve the understanding of the relationship between region-specific regulations of medications used in the manufacture of illegal drugs and illegal drug markets.

Design/methodology/approach
This paper examines a case study of the relationship between the regulation of medications containing pseudoephedrine in Czechia and neighbouring countries and the illegal drug market for methamphetamine in Czechia between 2006 and 2018. The description of this case is based on a review of the literature and a review of publicly available data sources.

Findings
The tightening of the regulation of medications containing pseudoephedrine in the Czech Republic led, in the years under study, to a gradual decrease in the number of packages sold and simultaneously to the illegal import of such medications from neighbouring countries with less strict regulations. At the same time, shifts in the drug market could be observed: the internationalisation of previously primarily domestic supply chains, the increased involvement of Vietnamese organised crime groups, the emergence of large-scale methamphetamine labs and a shift in production to countries with less strict regulations. The subsequent application of stricter controls in neighbouring countries was accompanied by further shifts in supply chains and increased imports from non-European countries.

Practical implications
The tightening of regulations of medications within a single country or single region might lead to significant and undesirable changes in drug markets and supply chains.

Originality/value
This paper provides a novel case study of the development of region-specific regulations of medications and their influence on illegal drug markets and supply chains in the Czech Republic and in the European context.
Testing the Integrative Quality Care Assessment Tool (INQUAT)
Authors: Amati Rebecca , Bellandi Tommaso , Kaissi Amer A. , Hannawa Annegret F. 
Published: January 2020

Purpose
Identifying the factors that contribute or hinder the provision of good quality care within healthcare institutions, from the managers’ perspective, is important for the success of quality improvement initiatives. The purpose of this paper is to test the Integrative Quality Care Assessment Tool (INQUAT) that was previously developed with a sample of healthcare managers in the USA.

Design/methodology/approach
Written narratives of 69 good and poor quality care episodes were collected from 37 managers in Italy. A quantitative content analysis was conducted using the INQUAT coding scheme, to compare the results of the US-based study to the new Italian sample.

Findings
The core frame of the INQUAT was replicated and the meta-categories showed similar distributions compared to the US data. Structure (i.e. organizational, staff and facility resources) covered 8 percent of all the coded units related to quality aspects; context (i.e. clinical factors and patient factors) 10 percent; process (i.e. communication, professional diligence, timeliness, errors and continuity of care) 49 percent; and outcome (i.e. process- and short-term outcomes) 32 percent. However, compared to the US results, Italian managers attributed more importance to different categories’ subcomponents, possibly due to the specificity of each sample. For example, professional diligence, errors and continuity of care acquired more weight, to the detriment of communication. Furthermore, the data showed that process subcomponents were associated to perceived quality more than outcomes.

Research limitations/implications
The major limitation of this investigation was the small sample size. Further studies are needed to test the reliability and validity of the INQUAT.

Originality/value
The INQUAT is proposed as a tool to systematically conduct in depth analyses of successful and unsuccessful healthcare events, allowing to better understand the factors that contribute to good quality and to identify specific areas that may need to be targeted in quality improvement initiatives.
Do justice and trust affect acceptability of Indonesian social health insurance policy?
Authors: Zein Rizqy Amelia , Putri Nuzulul Kusuma , Ridlo Ilham Akhsanu 
Published: January 2020

PurposeThe purpose of this paper is to investigate whether justice, trust in healthcare services, the confidence level of the health system and institutions, political party support and evaluation of healthcare services post-Jaminan Kesehatan Nasional (JKN) affected policy acceptability (PA) in the health workers (n=95) and laypeople (n=308) sample.Design/methodology/approachThe authors performed a two-level, linear mixed-effects model to test the hypothesis that trust, perceived justice, confidence in healthcare services and national health system evaluation could impact PA in the health workers and laypeople sample. The authors calculated the effect sizes by comparing Level 2 variances and residuals of the null model and the random intercept model.FindingsThe findings suggested that healthcare workers with high concern for justice would be more likely to hold negative acceptability to JKN. The findings implied that health workers tend to associate JKN with unfairness. Also, JKN acceptability in laypeople sample was found to be positively associated with the evaluation of healthcare service post-JKN, whereas justice or political party support did not affect JKN acceptability. It might indicate that laypeople motives for joining JKN scheme could be essentially pragmatic.Research limitations/implicationsThe authors administered the questionnaire using an online platform and circulated it through social media and IMS, so that this research poses a problem of self-selection bias, which potentially leads to biased estimates. The authors also oversampled female participants, especially in laypeople sample.Originality/valueAiming at universal health coverage in 2019, JKN will cover almost 300m Indonesians and be one of the biggest single-payer national health insurance scheme in the world. The research might offer insight into how health workers and laypeople respond to the policy.
The experiences of colorectal cancer patients in postoperative recovery: integrative review
Authors: Changyai Khwanhathai , Kongvattananon Puangpaka , Somprasert Chomchuen 
Published: January 2020

Purpose
The purpose of this paper is to synthesize the experiences and needs of colorectal cancer patients during postoperative recovery.

Design/methodology/approach
This study is an integrative review, conducted by CINAHL, PubMed, ScienceDirect and ThaiJO from 2009 to 2019. Ten research articles published have been selected by PRISMA process.

Findings
Results show the experiences of colon cancer patients during postoperative recovery consisted of four themes, namely suffering, decreased activity, ambivalent feeling and need of caring.

Research limitations/implications
The health care personnel should be aware of these experiences and give holistic care in order to let the patients free from unpleasant experiences and receive the responses which really meet their needs.

Originality/value
Knowledge about the experience and needs of colorectal cancer patients after surgery is of great benefit to healthcare providers who are planning the care, so as to achieve complete holistic care in the future research.
Effects of different miracle fruit products on the sensory characteristics of different types of sour foods by descriptive analysis
Authors: Choi Sung Eun , Garza Jeff 
Published: January 2020

AbstractMiracle fruit's potential benefit is encouraging as a powerful antioxidant and sweetness enhancer due to its novel ability to modify sour taste to sweet. However, further studies are needed to evaluate the practicality of different miracle fruit products. Thus, this study aimed to characterize the taste modification effects of different miracle fruit products on different sour foods. For this, 10 trained subjects (80% female, 50% white, Mean ± SE = 27.3 ± 3.9 years old) performed a Quantitative Descriptive Analysis using a Latin Square design with three replications. One session was composed of pre‐ and posttest for miracle fruit administration. Five food samples (green apple, goat cheese, lemonade, plain fat‐free yogurt, and cucumber pickle) and four miracle fruit products (three different brands of miracle fruit pill‐Y, G, M and one powder product‐P) were used and data were analyzed using analysis of variance and principal component analysis. The typical effects of miracle fruit, sweetness increase and sourness suppression were observed for all food samples albeit to different degrees. Y and M pills were most impactful while powder product was least, and goat cheese and yogurt had the most pronounced impact at increasing sweetness. Prior Miracle Fruit administration significantly decreased bitterness and increased creaminess in yogurt. However, it increased off‐flavor in lemonade and pickle. Results suggest that miracle fruit usage for increasing sweetness is effective but the degree of taste‐modifying effect differs according to the types of miracle fruit product and food samples applied.Practical ApplicationThis research confirms miracle fruit's unique taste‐modifying abilities and demonstrates a high potential as a sweetness enhancer to benefit human health. The results can be used to optimize miracle fruit's application and can be applied by food industry and health care provider to develop clinical remedies or disease prevention strategies.
Coagulation tests on admission correlate with mortality and morbidity in general ICU patients: An observational study
Authors: Benediktsson Sigurdur , Hansen Claudia , Frigyesi Attila , Kander Thomas 
Published: January 2020

BackgroundIt is well known that low platelet count on admission to intensive care units (ICU) is associated with increased mortality. However, it is unknown whether prothrombin time (PT‐INR) and activated partial thromboplastin time (APTT) on admission correlate with mortality and organ failure. Therefore, the aim of this study was to investigate whether PT‐INR and APTT at admission can predict outcome in the critically ill patient after adjusting for severity of illness measured with Simplified Acute Physiology Score 3 (SAPS 3).Materials and MethodsData were retrospectively collected. APTT and PT‐INR taken on admission and SAPS 3 score were independent variables in all regression analyses. Survival analysis was done with Cox regression. Organ failure was reported as days alive and free (DAF) of vasopressors and invasive ventilation, need of continuous renal replacement therapy (CRRT) and Acute Kidney Injury Network creatinine score (AKIN‐crea).ResultsA total of 3585 ICU patients were included. Prolonged APTT correlated with mortality with 95% confidence interval (CI) of hazard ratio 1.001‐1.010. Prolonged APTT also correlated with DAF vasopressor, CRRT and AKIN‐crea with 95% CI of odds ratio (OR) 1.009‐1.034, 1.016‐1.037 and 1.009‐1.028, respectively. Increased PT‐INR correlated with DAF vasopressor and DAF ventilator with 95% CI of OR 1.112‐2.014 and 1.135‐1.847, respectively.ConclusionsActivated partial thromboplastin time prolongation was associated with mortality and all morbidity outcomes except the DAF ventilator. PT‐INR increase at admission was associated with DAF vasopressor and DAF ventilator. APTT and PT‐INR at admission correlate with morbidity, which is not accounted for in the SAPS 3 model.
Asymmetric effects of voluntary disclosure on stock liquidity: evidence from 8‐K filings
Authors: Cho Hyunkwon , Kim Robert 
Published: January 2020

AbstractThis paper examines whether the change in stock liquidity subsequent to voluntary disclosure is different between good news and bad news. Using voluntary 8‐K filings, we find that the increase in stock liquidity is more pronounced for firms with good news disclosure than for firms with bad news disclosure. In addition, such findings are stronger when a firm is less visible and when the short‐selling costs are high, suggesting that these two factors play an important role in increasing stock liquidity. Overall, this paper provides evidence that the tone of voluntary 8‐K news is an important determinant of stock liquidity.
Ultrasound assessment of maternal adipose tissue during 1st trimester screening for aneuploidies and risk of developing gestational diabetes
Authors: D’Ambrosi Francesco , Rossi Gabriele , Soldavini Chiara M. , Di Maso Matteo , Carbone Ilma F. , Cetera Giulia E. , Colosi Enrico , Ferrazzi Enrico 
Published: January 2020

AbstractIntroductionThe objective of the present study is to compare the sonographic measurement of subcutaneous adipose thickness and visceral adipose thickness during 1st trimester screening for aneuploidies between non‐diabetic pregnant women and patients who develop 1st trimester or 2nd trimester gestational diabetes mellitus (GDM).Material and methodsAdipose thickness was measured by transabdominal ultrasound imaging in pregnant women attending our clinic for screening for fetal aneuploidies between 11 and 13 weeks of gestation. During the 1st trimester all patients were evaluated for fasting glycemia in accordance with the International Association of Diabetes and Pregnancy Study Groups (IADPSG) recommendations. Patients with confirmed fasting glycemia (FPG) ≥92 mg/dL were diagnosed as 1st trimester GDM. Patients with FPG <92 mg/dL underwent a 75‐g oral glucose tolerance test between 24 and 28 weeks.ResultsThe study population included 238 non‐diabetic women, 29 women with 1st trimester GDM and 28 women with 2nd trimester GDM. Mean subcutaneous adipose thickness and visceral adipose thickness values in non‐diabetic women were 9.8 mm (standard deviation [SD = 4.9) and 7.2 mm (SD = 3.5), respectively. Values in women with 1st trimester GDM were 12.8 mm (SD = 6.5) and 9.9 mm (SD = 4.4). In the 2nd trimester GDM group, the mean subcutaneous adipose thickness was 11.1 mm (SD = 4.6) and the mean visceral adipose thickness 10.5 mm (SD = 5.3). Multiple logistic regression analysis showed that visceral adipose thickness, but not subcutaneous adipose thickness, was significantly and independently associated with both 1st trimester GDM (OR 1.15, 95% CI 1.02‐1.29) and 2nd trimester GDM (odds ratio [OR] 1.19, 95% confidence interval [CI] 1.05‐1.34).ConclusionsSonographic thickness of maternal visceral adipose tissue was greater in women with GDM than in non‐diabetic patients, independently of other known risk factors associated with GDM in the 1st and in the 2nd trimester of pregnancy. Thus, this measurement may be considered of clinical use in 1st trimester screening.
A retrospective 10‐year mean follow‐up of implants placed in ridges grafted using autogenous mandibular blocks covered with bovine bone mineral and collagen membrane
Authors: Chiapasco Matteo , Tommasato Grazia , Palombo David , Del Fabbro Massimo 
Published: January 2020

AbstractObjectivesTo report the clinical and radiographic outcomes of patients presenting with edentulous and atrophic ridges and treated with autogenous mandibular bone blocks and rehabilitated with implant‐supported prostheses.Materials and methodsFrom 1997 to 2015, 75 patients presenting with bone defects of the jaws were grafted with autogenous mandibular bone blocks. One‐hundred eighty‐two implants were placed 4 to 12 months later and loaded 3 to 10 months later: the mean follow‐up was 10 years (range: 3–16 years). The following outcomes were recorded: (a) complication rate of the reconstructive procedure; (b) bone graft resorption before implant placement; (c) peri‐implant bone resorption; (d) implant‐related complications; and (e) implant survival and success rates.ResultsPostoperative recovery was uneventful in the majority of patients. An early dehiscence occurred in three patients, but with no significant bone loss, while 3 experienced temporary paraesthesia. The mean vertical and horizontal bone resorption before implant placement was 0.18 mm (standard deviation [SD] = 0.43) and 0.15 mm (SD = 0.42), respectively. The mean peri‐implant bone loss ± standard deviation was 1.06 ± 1.19 (range: 0.00–5.05) at patient level and 1.11 ± 1.26 (range: 0.00–5.20) at implant level. Two implants in 2 patients lost integration and were removed; 10 implants in 7 patients developed peri‐implantitis, but healed after surgical treatment. The cumulative implant survival and success rates were 98.11% and 85.16%, respectively.ConclusionImplants placed in areas reconstructed with mandibular bone blocks presented survival rates consistent with those obtained for implants placed in native bone.
Comparison of the Moorehead‐Ardelt quality of life questionnaire and the BODY‐Q in Danish patients undergoing weight loss and body contouring surgery
Authors: Poulsen Lotte , Simonsen Nina , Klassen Anne F. , Cano Stefan , Rose Michael , Juhl Claus B. , Stoving Rene K. , Andries Alin , Sorensen Jens A. 
Published: January 2020

SummaryThis study compared the measurement properties of the Moorehead‐Ardelt quality of life questionnaire‐II (MAQOL‐II) and the BODY‐Q, to determine which was more suitable for measuring patient‐reported outcome (PRO) in Danish bariatric surgery (BS) and body contouring surgery (BC) patients. We examined content validity against the COSMIN guidelines and compared psychometric performance using Rasch measurement theory methods and criteria. MAQOL‐II data were obtained from the Danish Bariatric Surgery Database from September 2010 to November 2017, and BODY‐Q data were collected from June 2015 to March 2018. The MAQOL‐II failed to meet recommended standards for content validity, while all criteria were met for the BODY‐Q. A total of 16 965 MAQOL‐II and 2259 BODY‐Q assessments were obtained. A random sample was selected from the MAQOL‐II dataset to match the BODY‐Q sample. Psychometrically, the BODY‐Q performed better than the MAQOL‐II. For example, Cronbach's α was 0.82 for the MAQOL‐II vs ≥0.90 for all BODY‐Q scales. Fifty percent (3/6) of MAQOL‐II items had disordered thresholds, while all BODY‐Q items had ordered thresholds (123/123). Poor item fit was revealed for 17% (1/6) of MAQOL‐II and 8% (10/123) of BODY‐Q items. For scale reliability, person separation index was 0.79 for the MAQOL‐II and 0.88 (0.81‐0.93) for the BODY‐Q. In conclusion, the MAQOL‐II does not meet today's standards for a rigorously developed PRO measure. The BODY‐Q, on the other hand, gives substantial, accurate and interpretable measurement and should be recommended for use in PRO in BS and BC patients.