bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short or Long Sleep Duration and CKD: A Mendelian Randomization Study
Authors: Park Sehoon , Lee Soojin , Kim Yaerim , Lee Yeonhee , Kang Min Woo , Kim Kwangsoo , Kim Yong Chul , Han Seung Seok , Lee Hajeong , Lee Jung Pyo , Joo Kwon Wook , Lim Chun Soo , Kim Yon Su , Kim Dong Ki 
Published: October 2020

Significance Statement
Poor sleep is known to be related to kidney function impairment. Using the UK Biobank cohort, including individuals self-reporting regular sleep patterns of short, intermediate, or long duration, the authors found that short or long sleep duration was associated with higher prevalence of CKD. In the genetic analysis, the genetic risk score for short but not long sleep duration was significantly related to a higher risk of CKD stages 3–5, suggesting causal effects of short sleep duration on CKD. Two-sample Mendelian randomization analysis, using the independent meta-analysis results of kidney function from the CKDGen Consortium genome-wide association study, also showed significant causal estimates of short sleep duration on CKD. Clinicians may thus consider encouraging patients to avoid short-duration sleeping behavior to reduce the risk of CKD.

Background
Studies have found sleeping behaviors, such as sleep duration, to be associated with kidney function and cardiovascular disease risk. However, whether short or long sleep duration is a causative factor for kidney function impairment has been rarely studied.

Methods
We studied data from participants aged 40–69 years in the UK Biobank prospective cohort, including 25,605 self-reporting short-duration sleep (<6 hours per 24 hours), 404,550 reporting intermediate-duration sleep (6–8 hours), and 35,659 reporting long-duration sleep (≥9 hours) in the clinical analysis. Using logistic regression analysis, we investigated the observational association between the sleep duration group and prevalent CKD stages 3–5, analyzed by logistic regression analysis. We performed Mendelian randomization (MR) analysis involving 321,260 White British individuals using genetic instruments (genetic variants linked with short- or long-duration sleep behavior as instrumental variables). We performed genetic risk score analysis as a one-sample MR and extended the finding with a two-sample MR analysis with CKD outcome information from the independent CKDGen Consortium genome-wide association study meta-analysis.

Results
Short or long sleep duration clinically associated with higher prevalence of CKD compared with intermediate duration. The genetic risk score for short (but not long) sleep was significantly related to CKD (per unit reflecting a two-fold increase in the odds of the phenotype; adjusted odds ratio, 1.80; 95% confidence interval, 1.25 to 2.60). Two-sample MR analysis demonstrated causal effects of short sleep duration on CKD by the inverse variance weighted method, supported by causal estimates from MR-Egger regression.

Conclusions
These findings support an adverse effect of a short sleep duration on kidney function. Clinicians may encourage patients to avoid short-duration sleeping behavior to reduce CKD risk.
Discovery of Ulaanbaatar Fault: A New Earthquake Threat to the Capital of Mongolia
Authors: Suzuki Yasuhiro , Nakata Takashi , Watanabe Mitsuhisa , Battulga Sukhee , Enkhtaivan Dangaa , Demberel Sodnomsambuu , Odonbaatar Chimed , Bayasgalan Amgalan , Badral Tuvshin 
Published: September 2020

AbstractDestructive large earthquakes occur not only along major plate boundaries but also within the interior of plates. To establish appropriate safety measures, identifying intraplate active faults and the potential magnitude of associated earthquakes is essential before an earthquake occurs. This study was conducted to document the geomorphic expression of a previously unrecognized 50-km-long active fault in Ulaanbaatar, the capital of Mongolia. Mapping of the fault was accomplished using the Advanced Land Observation Satellite elevation dataset provided by Japan Aerospace Exploration Agency (JAXA), a stereo-scope interpretation of CORONA satellite images, the emplacement of trenches across the fault trace, and field study. The Ulaanbaatar fault (UBF) is marked by fault scarps on the surface and left-lateral stream deflections. The fault displaces late Pleistocene deposits and is thus considered to be active. Based on the length of the fault, the UBF is believed to be capable of causing earthquakes with magnitudes greater than M 7 and subsequent associated damage to buildings and heavy causalities within the metropolitan area. We strongly suggest that building resistance requirements in Ulaanbaatar should be revised to mitigate for the potential of extensive seismic damage. The results of this study can be used to revise the seismic hazard map and stipulate a new disaster prevention strategy to improve public safety in Ulaanbaatar. It is also possible that there may be other active faults in the vicinity of Ulaanbaatar, and these require investigation.
Sensitivity Analysis of the Interfrequency Correlation of Synthetic Ground Motions to Pseudodynamic Source Models
Authors: Song Seok Goo , Causse Mathieu , Bayless Jeff 
Published: September 2020

AbstractGiven the deficiency of recorded strong ground-motion data, it is important to understand the effects of earthquake rupture processes on near-source ground-motion characteristics and to develop physics-based ground-motion simulation methods for advanced seismic hazard assessments. Recently, the interfrequency correlation of ground motions has become an important element of ground-motion predictions. We investigate the effect of pseudodynamic source models on the interfrequency correlation of ground motions by simulating a number of ground-motion waveforms for the 1994 Northridge, California, earthquake, using the Southern California Earthquake Center Broadband Platform. We find that the cross correlation between earthquake source parameters in pseudodynamic source models significantly affects the interfrequency correlation of ground motions in the frequency around 0.5 Hz, whereas its effect is not visible in the other frequency ranges. Our understanding of the effects of earthquake sources on the characteristics of near-source ground motions, particularly the interfrequency correlation, may help develop advanced physics-based ground-motion simulation methods for advanced seismic hazard and risk assessments.
SeisNoise.jl: Ambient Seismic Noise Cross Correlation on the CPU and GPU in Julia
Authors: Clements Timothy , Denolle Marine A. 
Published: September 2020

AbstractWe introduce SeisNoise.jl, a library for high-performance ambient seismic noise cross correlation, written entirely in the computing language Julia. Julia is a new language, with syntax and a learning curve similar to MATLAB (see Data and Resources), R, or Python and performance close to Fortran or C. SeisNoise.jl is compatible with high-performance computing resources, using both the central processing unit and the graphic processing unit. SeisNoise.jl is a modular toolbox, giving researchers common tools and data structures to design custom ambient seismic cross-correlation workflows in Julia.
Comparison of change of corneal astigmatism in pre and post operated pterygium excision
Authors: Kumar Harish , Kumar Ram 
Published: October 2020

Pterygium is a wing shaped fibrovascular growth of subconjunctival tissue encroaching upon cornea within interpalpebral fissure area causing significant astigmatism. Surgery for excision of pterygium leads to decrease in astigmatism which significantly improves vision.Comparison of change of corneal astigmatism in pre and post operative ptrygium excision and visual outcome.The study was carried out on 40 eyes of 40 patients who had primary pterygium, admitted in department of ophthalmology B R D Medical college Gorakhpur; divided in two groups; underwent pterygium excision during period of December 2018 to November 2019. All patients underwent pre operative assessment for visual acuity, refraction, slit lamp examination, keratometry.It was found that corneal astigmatism decreased progressively in both group after day 1, week 1, week 2, week 4 and after 12 week post operatively.During follow up at 12 weeks in both groups best corrected visual acuity was found improved and also corneal astigmatism decreased in both group.: Pterygium induces significant corneal astigmatism. Surgery of pterygium leads to significant decrease in corneal astigmatism and increased visual acuity.
Gender, activism and social change: Reframing the contemporary heroine
Authors: Díaz de Sabatés Gabriela 
Published: October 2020

Because society is shaped through the stories we tell, women’s testimonies are of foundational relevance when we reflect on social change, since their stories reinvent not only individual but also collective identity. As an examination from a life narrative perspective on how women view, enact, and reformulate their role in society, this paper centers on the testimony of Dr. Diana Maffía, whom –among other noteworthy womenwas instrumental in solidifying the work on gender and feminist perspective in Argentina since the early 1980s.
This paper is an approach to Maffía’s story, about her growing up during military dictatorship, her early years as a philosophy student at the University of Buenos Aires, her embrace of feminism, and the weaving of her two passions that resulted in the establishment of a permanent presence of the concept of gender within the very structure of Argentinean society. Maffía’s narrative brings to light the work that unsung heroines do throughout their lives, evidencing that women have always been at the forefront of generating and sustaining change.
Obstetric Brachial Plexus Palsy and Rehabilitation Process: Case Presentation
Authors: CANBAY DURMAZ Sevda , SOLGUN Selma , ÖZBAĞ Davut , CANBAY Ali 
Published: October 2020

Obstetric brachial plexus palsy (OBPP) is a clinical situation induced by the damage to the plexus brachialis and the branches originating from its location. While the diagnosis of OBPP can be made with a detailed examination performed right after the baby is born, it may limit the daily life activities of the child throughout his/her life when the situation noticed at a late stage. Treatment for OBPP can be grouped as conservative treatment, palliative surgery during conservative treatment, surgical therapy and late period treatment. In addition to all these, the physical therapy and rehabilitation processes are initiated for the patient from the moment the patient is diagnosed. The aim of the study is to reveal the importance of the early physiotherapy and rehabilitation program and the significance of the regular exercise program not neglected after a series of operations, in OBPP treatment. In this case presentation, we will present a 9-year treatment program, physiotherapy and rehabilitation period of a female patient with OBPP diagnosed at the time of birth, and her condition before and after this process.
Ginástica para todos
Authors: Menegaldo Fernanda Raffi , Bortoleto Marco Antonio Coelho 
Published: September 2020

Objetivo: Este estudo tem como objetivo refletir sobre a prática da Ginástica para Todos (GPT) a partir da teoria da Praxiologia Motriz, teoria desenvolvida pelo francês Pierre Parlebas. Metodologia: Caracterizado como um estudo teórico, este ensaio é construído a partir da análise da Lógica Interna da prática, com ênfase em seu caráter sociomotriz, e as possíveis aproximações entre a GPT e o subdomínio denominado Situações Motrizes Expressivas (SME). Resultados e discussão: A análise das características fundantes da GPT, considerando sua prática não-competitiva, mostra a ausência de códigos gestuais, e a possibilidade de uma prática gímnica sociomotriz com a emergência de múltiplas lógicas internas. Conclusão: Numa perspectiva praxiológica, as fronteiras pouco demarcadas da GPT distanciam essa prática do esporte e a aproximam às SME, reforçando seu caráter comunicativo e a relevância das relações cooperativas para a sua prática.
Direct Acting Antivirals in Hepatitis C-Infected Kidney Transplant Recipients: Associations with Long-term Graft Failure and Patient Mortality
Authors: Goetsch Michael R , Tamhane Ashutosh , Overton Edgar T , Towns Graham C , Franco Ricardo A 
Published: October 2020

Background: Direct-acting antiviral (DAA) therapy among hepatitis C virus (HCV)-infected kidney transplant recipients is associated with short-term improvement in protein/creatinine (P/C) ratios, but how HCV cure affects long-term graft outcomes remains unknown.Methods: This is a retrospective follow-up study of 59 HCV-infected patients who underwent kidney transplant at the University of Alabama at Birmingham between 2007-2015 who were followed until the end of 2017. We examined the association of DAA-induced HCV cure with graft failure or death by survival analyses (Kaplan-Meier, Cox regression).Redsults: Mean age was 55 years, 73% were African American, and 68% were male. Median baseline creatinine was 1.4 mg/dL, P/C ratio was 0.5, and estimated glomerular filtration rate (eGFR) was 59 mL/min. Of those who received DAA, 24 (83%) achieved cure. The remaining 5 DAA patients (17%) did not have documented evidence of sustained virologic response (SVR). Overall, 19 (32%) patients experienced graft failure or death; with lower incidence in treated patients than untreated (4 vs 15 events; 2.6 vs 10.3 per 100 person-years [cHR 0.19, 95% CI: 0.06–0.66]). When adjusted for age, sex, race, and proteinuria, the association remained strong and invariant across time-varying (aHR 0.30, 95% CI: 0.08–1.10), time-averaged (aHR 0.28, 95% CI: 0.07–1.07), and time-varying-cumulative (aHR 0.32, 95% CI: 0.08–1.21) proteinuria metrics.Conclusions: DAAs therapy was associated with improved graft survival and reduced mortality. While not statistically significant, the association was strong, and these single-center findings warrant larger studies to demonstrate the benefits of HCV treatment in this population.
The Effect of Ethanol Extract 96% o Brown Rice Bran to the Number and Viability of White Rat (Rattus norvegicus) Spermatozoa Sprague dawley Strains Induced by Clove Cigarette Smoke
Authors: Rahmanisa Soraya , Hayatillah Natasya , Kurniawaty Evi 
Published: October 2020

Abstract: Indonesia has the greatest number of smokers in Southeast Asia dominated by male consume kretek cigarette. Cigarette’s smoke is source of free radicals that can cause oxidative stress to sperm and lead it to infertility. Red rice bran extract has lot of potential antioxidants to stop oxidatif stress. This study was experimental within 30 days. The 25 Sprague dawley male rats divided into 5 groups: K1 wasn’t treated, K2,P1,P2, and P3 exposed to smokes of 2 kretek cigarettes, given 96% ethanol extract of red rice bran dosage 100 mg/Kg (P1), 200 mg/Kg (P2) and 400 mg/Kg (P3). Spermatozoa number and viability was observed. Data tested with One Way Anova. There was significant effect from red rice bran extract toward sperm number and viability (p=0,00). Average spermatozoa number was 91.90±7.72 (K1), 39.68±7,51 (K2), 79.88±8.63 (P1), 86.40±10.5 (P2), 86.00±5.78 (P3). Average viability was 65.00±6.85 (K1), 29.6±5.85 (K2), 51.4±3.50 (P1), 60.00±6.67 (P2), 61,00±2.91 (P3). The increasing of number and viability has been achived at dose 100mg/Kg and best at 400 mg/KgBB. The 96% ethanol extract of red rice bran can prevent the decreasing number and viability of rat spermatozoa exposed by kretek cigarette. Keywords: Clove cigarette, spermatozoa, rice bran extract
Biotoxic of Gemor (Nothaphoebe coriacea) Leaves from Peat Swamp Tumbang Nusa Research Forest, Central Kalimantan, Indonesia
Authors: Thalib Iskandar , Santosa Purwanto Budi , Suhartono Eko 
Published: October 2020

Abstract: The study aimed to evaluate the sub-acute toxicity effect of aqueous N. coriacea leaves extract to kidney and liver function. The biotoxic study was conducted using male rats. In this study, the experimental animals received five different doses of aqueous N. coriacea leaves extract (0.1 mg, 1 mg, 10 mg, 100 mg, and 1000 mg per day) for 4 weeks via oral route. After treatment, the level of plasma ureum, creatinine, Aspartate Transaminase (AST) and Alanine Transaminase (ALT) level were measured. The results show that most of dose treatments of aqueous extract of N. coriacea leaves had not statistically effect on the level of the plasma ureum and creatinine except for dosage of 1000 mg. Similarly, the dose treatments of that extract did not statistically change the plasma AST and ALT, except on 100 and 1000 mg/kg of b.w extract dose. In conclusion, a short-term intake of N. coriacea leaves extract via oral route was not toxic to kidney and liver. Keywords: N. coriacea, Kidney, Liver, Toxicity.
Antifospholipid Syndrome with Autoimun Hemolitic Anemia
Authors: Zukhrufan Muhammad Huki , Wahid Irza 
Published: October 2020

Abstract: Antiphospholipid syndrome is a part of systemic autoimmune disease (nonspecific organ), characterized by vascular thrombosis (arterial or venous) with a high antibody titter against a plasma protein that binds to phospholipid anions (antiphospholipid-aPL antibodies). Autoimmune haemolytic anaemia (AIHA) is rare in patients with antiphospholipid antibody syndrome. A sixteen years old female patient has been reported with the main complaint of swelling in the right leg. The patient also complained of increased fatigue. On physical examination found anaemic conjunctiva, swelling in the right limb with a diameter of the right leg greater than the left leg. Homan’s sign positive on the right leg. This patient belongs to the high probability criteria of DVT. Doppler Ultrasonography (USG) examination suggests thrombus in the iliac vein, femoral vein, and right leg popliteal vein, and thrombus in the left leg popliteal vein. In the antibody anticardiolipin (ACA) IgG examination an increase was found. The comb test was positive, and haemolytic anaemia antibody screening was the warm type. Heparinisation and immunosuppressant administration were performed in patients. The incidence of antiphospholipid syndrome with AIHA cannot be ascertained whether there is a direct relationship. Keywords: antiphospholipid syndrome, DVT, AIHA
Profile of Musculoskeletal Tumor in Saiful Anwar General Hospital Malang from January 2011 until December 2018
Authors: Irsan Istan Irmansyah , Isma Satria Pandu Persada , Aziz Abdul , Bimadi Muhammad Hilman , Oktafandi I Gusti Ngurah Arga Aldrian 
Published: October 2020

Abstract: Musculoskeletal tumors are relatively rare, with 0.2%-0.5% of all malignant tumors in all ages. The geographic distribution of musculoskeletal tumors varies significantly around the world. This study aims to describe the musculoskeletal tumor profile in Saiful Anwar General Hospital. All data were obtained from the department of orthopaedic and traumatology database, Saiful Anwar general hospital. Thus, patients who were diagnosed with either bone tumor or soft tissue tumor between January 2011 to December 2018 were selected for the present study. The clinical-pathological conference (CPC) was carried out to ensure the validity of all the registered data. A total of 577 patients with tumors from January 2011 to December 2018 was obtained. Out of all the cases, 439 (76%) cases are bone tumors, and the remaining 138 (24%) cases are soft tissue tumors. The most frequent locations of the musculoskeletal tumors are the long bones of the thigh and lower leg. This study shows an increasing trend in musculoskeletal tumors incidence, despite decreasing numbers in several years. This result goes along with a rising trend in malignancy cases with a higher amount compared to the benign one. Moreover, MBD and osteosarcoma were found to be the most common tumor and primary bone tumors, respectively. However, the fact that there is some data loss in the study limited the study for a more accurate result. Keywords: Musculoskeletal tumor; Bone tumor; Osteosarcoma; Malang; East Java
Identification of Bacteria, Fungi, and Most Probable Coliform around Temporary Disposal Site at Gadang Village Banjarmasin
Authors: Heriyani Farida , Budiarti Lia Yulia , Rafina Nurlaili , Novianti Normaida , Sella Puspa Astri 
Published: October 2020

Abstract: Temporary Disposal Site (TDS) of Gadang Village Banjarmasin is one of the temporary landfills in Banjarmasin. The negative effects of waste can pollute the environment, including water and air. The purpose of this study was to identify airborne contaminant bacteria and fungi as well as the Most Probable Number (MPN) of Coliform value of piped water in the residential houses around Gadang TDS Banjarmasin. The research method is descriptive observational. The sample of this study were air and piped water. Air sampling is done by open plate and MPN Coliform sampling was obtained by purposive sampling method. The results of this study showed the air contaminant bacteria in the house were Staphylococcus aureus (55.56%) and Escherichia coli (44.44%) in the environment around the TDS all results were obtained with the same percentage. Aspergillus niger was dominantly found at a distance of 20-30 m and 40-50 m while Aspergillus flavus was mostly found at the distance around 30-40 m. MPN Coliform in piped water showed coliform bacteria contamination with MPN coliform index of 2.0-7.5/100ml water samples. In conclusion, Staphylococcus aureus bacteria is more common than Escherichia coli. Most fungi species found in this study was Aspergillus niger. In the piped water examination for all samples MPN Coliform was found in the low risk category. Keywords: Air contaminant bacteria, air contaminant fungi, piping water MPC coliform, Temporary Disposal Site
Stage 4 Lung Cancer with Brain and Pericardial Metastases Which Are First Considered as Pulmonary Tuberculosis Infection and Heart Failure
Authors: Haryati Haryati , Riska Marsheilla 
Published: October 2020

Abstract: Lung cancer and pulmonary tuberculosis become a global problem in the world. The similarities of clinical symptoms and radiological appearances often complicates diagnosis especially in TB endemic countries. A 43-year-old man presented with shortness of breath for 6 months, accompanied by intermittent cough mixed with blood streaks. He had been taking anti-tuberculosis for 2 months, but there’s no improvement. On physical examination, ronchi were heard in the lower 2/3 of the right lung and heart sounds diminished. Motoric movement of the left hand was difficult to grasp hard. A contrast-enhanced CT scan of the head revealed hyperdense multiple nodules. Chest X-ray showed cardiomegaly with right lung consolidation and a primary malignant right lung mass accompanied by pericardial effusion at thoracic CT scan. Cytology and EGFR examination of pericardial effusion found adenocarcinoma metastasis with exon 18 and 21 mutations. Evaluation of clinical symptoms and radiological examination during tyrosine kinase inhibitor (TKI) therapy showed improvement. Lung cancer can resemble pulmonary tuberculosis in various manifestations. Adenocarcinoma with positive EGFR mutations is more commonly found in Asians. Cytology and EGFR examination of pericardial effusion became the basis of diagnosis in this case. He was given TKI therapy. Re-evaluation must be carried out in patients who do not improve with antibiotics or anti-tuberculosis. Patient reported a good response after consuming EGFR-TKI. Keywords: lung cancer, tuberculosis, tyrosine kinase inhibitors