bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Agenda for Open Science in Communication
Authors: Dienlin Tobias , Johannes Niklas , Bowman Nicholas David , Masur Philipp K , Engesser Sven , Kümpel Anna Sophie , Lukito Josephine , Bier Lindsey M , Zhang Renwen , Johnson Benjamin K , Huskey Richard , Schneider Frank M , Breuer Johannes , Parry Douglas A , Vermeulen Ivar , Fisher Jacob T , Banks Jaime , Weber René , Ellis David A , Smits Tim , Ivory James D , Trepte Sabine , McEwan Bree , Rinke Eike Mark , Neubaum German , Winter Stephan , Carpenter Christopher J , Krämer Nicole , Utz Sonja , Unkel Julian , Wang Xiaohui , Davidson Brittany I , Kim Nuri , Won Andrea Stevenson , Domahidi Emese , Lewis Neil A , de Vreese Claes 
Published: March 2020

Abstract
In the last 10 years, many canonical findings in the social sciences appear unreliable. This so-called “replication crisis” has spurred calls for open science practices, which aim to increase the reproducibility, replicability, and generalizability of findings. Communication research is subject to many of the same challenges that have caused low replicability in other fields. As a result, we propose an agenda for adopting open science practices in Communication, which includes the following seven suggestions: (1) publish materials, data, and code; (2) preregister studies and submit registered reports; (3) conduct replications; (4) collaborate; (5) foster open science skills; (6) implement Transparency and Openness Promotion Guidelines; and (7) incentivize open science practices. Although in our agenda we focus mostly on quantitative research, we also reflect on open science practices relevant to qualitative research. We conclude by discussing potential objections and concerns associated with open science practices.
Managing for Resilience? Examining Management Implications of Resilience in Southwestern National Forests
Authors: Greiner S Michelle , Grimm Kerry E , Waltz Amy E M 
Published: March 2020

AbstractThe United States Forest Service 2012 Planning Rule prioritizes making lands resilient to climate change. Although researchers have investigated the history of “resilience” and its multiple interpretations, few have examined perceptions or experiences of resource staff tasked with implementing resilience. We interviewed Forest Service staff in the Southwestern Region to evaluate how managers and planners interpret resilience as an agency strategy, execution of resilience in management, and climate change’s impact on perception of resilience. Interviewees identified resilience as a main driver of agency response to land management but, when applying the concept, experienced barriers including ambiguity; scale; management specificity versus broad, adaptive landscape approach; and lack of metrics or examples. Interviewees found restoring ecosystem function to promote resilience while planning for future changed landscapes difficult. They desired landscape-scale collaboration to understand how to operationalize the resilience directive. Our findings revealed obstacles and opportunities for resilience in a managerial context.
Fifty years of imported Lassa fever: a systematic review of primary and secondary cases
Authors: Wolf Timo , Ellwanger Regina , Goetsch Udo , Wetzstein Nils , Gottschalk Rene 
Published: March 2020

AbstractRationale for Systematic ReviewLassa fever is the most common cause of imported haemorrhagic fevers cases in non-endemic countries. As a disease with a high case fatality rate that has regularly caused clusters of nosocomial transmission in endemic areas, prompt diagnosis is vital. We conducted a systematic review of imported cases of the last 50 years with the aim of defining the clinical and epidemiological characteristics that will enhance early diagnosis, prompt initiation of treatment and an appropriate public health response to Lassa fever cases.MethodsWe performed a retrospective, systematic review of 36 primary and two secondary cases of Lassa fever in non-endemic countries outside West Africa by searching the PubMed database. This yielded 56 relevant publications that were included in our analysis.ResultsThe case fatality rate of 35.1% for imported cases was higher than that reported for endemic countries. The majority of patients showed clinical features consistent with Lassa fever and had a typical exposure. There was a considerable delay in diagnosis in imported cases with high associated numbers of contacts. Ribavirin was rarely used for post-exposure prophylaxis. Only two secondary transmissions occurred. Thirty-one percent of patients received Lassa fever-specific treatment and five required intensive care.ConclusionsAlthough importation of Lassa fever to non-endemic countries is a rare event, it has repeatedly happened over five decades. Suspicion of Lassa fever should be based on careful consideration of clinical features and exposure history in order to assist early diagnosis in returning travellers from West Africa.
The decline in the naturalization rate among recent immigrants in Canada: Policy changes and other possible explanations
Authors: Hou Feng , Picot Garnett 
Published: March 2020

AbstractThe naturalization rate of immigrants is jointly affected by immigrant characteristics, economic, and political circumstances in the source country and government policies in the destination country. This article focuses on the effect of altering government policies in the destination country, using legislative and regulatory changes introduced in Canada over the 2006–16 period as a test case. We hypothesize that the least advantaged immigrants would be most affected by more restrictive policies. The observed large decline in the naturalization rate among immigrants with low family income, low proficiency in official languages, and low educational levels is consistent with significant policy impacts. Furthermore, the general decline started before the introduction of the new policies, and the decline was particularly large among immigrants from Eastern Asia. This suggests that other factors such as globalization and changes in the socioeconomic environment of some source countries also played a role.
UV and U-band luminosity functions from CLAUDS and HSC-SSP – I. Using four million galaxies to simultaneously constrain the very faint and bright regimes to z ∼ 3
Authors: Moutard Thibaud , Sawicki Marcin , Arnouts Stéphane , Golob Anneya , Coupon Jean , Ilbert Olivier , Yang Xiaohu , Gwyn Stephen 
Published: March 2020

ABSTRACT
We constrain the rest-frame FUV (1546 Å), NUV (2345 Å), and U-band (3690 Å) luminosity functions (LFs) and luminosity densities (LDs) with unprecedented precision from z ∼ 0.2 to z ∼ 3 (FUV, NUV) and z ∼ 2 (U band). Our sample of over 4.3 million galaxies, selected from the CFHT Large Area U-band Deep Survey (CLAUDS) and HyperSuprime-Cam Subaru Strategic Program (HSC-SSP) data lets us probe the very faint regime (down to MFUV, MNUV, MU ≃ −15 at low redshift), while simultaneously detecting very rare galaxies at the bright end down to comoving densities &lt;10−5 Mpc−3. Our FUV and NUV LFs are well fitted by single-Schechter functions, with faint-end slopes that are very stable up to z ∼ 2. We confirm, but self-consistently and with much better precision than previous studies, that the LDs at all three wavelengths increase rapidly with lookback time to z ∼ 1, and then much more slowly at 1 &lt; z &lt; 2–3. Evolution of the FUV and NUV LFs and LDs at z &lt; 1 is driven almost entirely by the fading of the characteristic magnitude, $M^\star _{\rm UV}$, while at z &gt; 1 it is due to the evolution of both $M^\star _{\rm UV}$ and the characteristic number density $\phi ^\star _{\rm UV}$. In contrast, the U-band LF has an excess of faint galaxies and is fitted with a double-Schechter form; $M^\star _{U}$, both $\phi ^\star _{U}$ components, and the bright-end slope evolve throughout 0.2 &lt; z &lt; 2, while the faint-end slope is constant over at least the measurable 0.05 &lt; z &lt; 0.6. We present tables of our Schechter parameters and LD measurements that can be used for testing theoretical galaxy evolution models and forecasting future observations.
Updated parameter estimates for GW190425 using astrophysical arguments and implications for the electromagnetic counterpart
Authors: Foley Ryan J , Coulter David A , Kilpatrick Charles D , Piro Anthony L , Ramirez-Ruiz Enrico , Schwab Josiah 
Published: March 2020

ABSTRACT
The progenitor system of the compact binary merger GW190425 had a total mass of $3.4^{+0.3}_{-0.1}$ M⊙ (90th-percentile confidence region) as measured from its gravitational wave signal. This mass is significantly different from the Milky Way (MW) population of binary neutron stars (BNSs) that are expected to merge in a Hubble time and from that of the first BNS merger, GW170817. Here, we explore the expected electromagnetic (EM) signatures of such a system. We make several astrophysically motivated assumptions to further constrain the parameters of GW190425. By simply assuming that both components were NSs, we reduce the possible component masses significantly, finding $m_{1}=1.85^{+0.27}_{-0.19}$ M⊙ and $m_{2}=1.47^{+0.16}_{-0.18}$ M⊙. However, if the GW190425 progenitor system was an NS–black hole (BH) merger, we find best-fitting parameters $m_{1}=2.19^{+0.21}_{-0.17}$ M⊙ and $m_{2}=1.26^{+0.10}_{-0.08}$ M⊙. For a well-motivated BNS system where the lighter NS has a mass similar to the mass of non-recycled NSs in MW BNS systems, we find $m_{1}=2.03^{+0.15}_{-0.14}$ M⊙ and m2 = 1.35 ± 0.09 M⊙, corresponding to only 7 per cent mass uncertainties. For all scenarios, we expect a prompt collapse of the resulting remnant to a BH. Examining detailed models with component masses similar to our best-fitting results, we find the EM counterpart to GW190425 is expected to be significantly redder and fainter than that of GW170817. We find that almost all reported search observations were too shallow to detect the expected counterpart to GW190425. If the LIGO–Virgo Collaboration promptly provides the chirp mass, the astronomical community can adapt their observations to improve the likelihood of detecting a counterpart for similarly ‘high-mass’ BNS systems.
Epigenetic engineering of yeast reveals dynamic molecular adaptation to methylation stress and genetic modulators of specific DNMT3 family members
Authors: Finnegan Alex I , Kim Somang , Jin Hu , Gapinske Michael , Woods Wendy S , Perez-Pinera Pablo , Song Jun S 
Published: March 2020

Abstract
Cytosine methylation is a ubiquitous modification in mammalian DNA generated and maintained by several DNA methyltransferases (DNMTs) with partially overlapping functions and genomic targets. To systematically dissect the factors specifying each DNMT’s activity, we engineered combinatorial knock-in of human DNMT genes in Komagataella phaffii, a yeast species lacking endogenous DNA methylation. Time-course expression measurements captured dynamic network-level adaptation of cells to DNMT3B1-induced DNA methylation stress and showed that coordinately modulating the availability of S-adenosyl methionine (SAM), the essential metabolite for DNMT-catalyzed methylation, is an evolutionarily conserved epigenetic stress response, also implicated in several human diseases. Convolutional neural networks trained on genome-wide CpG-methylation data learned distinct sequence preferences of DNMT3 family members. A simulated annealing interpretation method resolved these preferences into individual flanking nucleotides and periodic poly(A) tracts that rotationally position highly methylated cytosines relative to phased nucleosomes. Furthermore, the nucleosome repeat length defined the spatial unit of methylation spreading. Gene methylation patterns were similar to those in mammals, and hypo- and hypermethylation were predictive of increased and decreased transcription relative to control, respectively, in the absence of mammalian readers of DNA methylation. Introducing controlled epigenetic perturbations in yeast thus enabled characterization of fundamental genomic features directing specific DNMT3 proteins.
Crosstalk between GBM cells and mesenchymal stemlike cells promotes the invasiveness of GBM through the C5a/p38/ZEB1 axis
Authors: Lim Eun-Jung , Kim Seungmo , Oh Yoonjee , Suh Yongjoon , Kaushik Neha , Lee Ji-Hyun , Lee Hae-June , Kim Min-Jung , Park Myung-Jin , Kim Rae-Kwon , Cha Junghwa , Kim Se Hoon , Shim Jin-Kyoung , Choi Junjeong , Chang Jong Hee , Hong Yong Kil , Huh Yong Min , Kim Pilnam , Kang Seok-Gu , Lee Su-Jae 
Published: March 2020

Abstract

Background
Mesenchymal stemlike cells (MSLCs) have been detected in many types of cancer including brain tumors and have received attention as stromal cells in the tumor microenvironment. However, the cellular mechanisms underlying their participation in cancer progression remain largely unexplored. The aim of this study was to determine whether MSLCs have a tumorigenic role in brain tumors.

Methods
To figure out molecular and cellular mechanisms in glioma invasion, we have cultured glioma with MSLCs in a co-culture system.

Results
Here, we show that MSLCs in human glioblastoma (GBM) secrete complement component C5a, which is known for its role as a complement factor. MSLC-secreted C5a increases expression of zinc finger E-box-binding homeobox 1 (ZEB1) via activation of p38 mitogen-activated protein kinase (MAPK) in GBM cells, thereby enhancing the invasion of GBM cells into parenchymal brain tissue.

Conclusion
Our results reveal a mechanism by which MSLCs undergo crosstalk with GBM cells through the C5a/p38 MAPK/ZEB1 signaling loop and act as a booster in GBM progression.

Key Points
1. MSLCs activate p38 MAPK-ZEB1 signaling in GBM cells through C5a in a paracrine manner, thereby boosting the invasiveness of GBM cells in the tumor microenvironment.
2. Neutralizing of C5a could be a potential therapeutic target for GBM by inhibition of mesenchymal phenotype.
The therapeutic efficacy of denosumab for the loss of bone mineral density in glucocorticoid-induced osteoporosis: a meta-analysis
Authors: Yamaguchi Yuta , Morita Takayoshi , Kumanogoh Atsushi 
Published: March 2020

Abstract

Objective
Prevention of steroidal osteoporosis is an important issue. There is no clear consensus on the impact of anti-RANKL antibody (denosumab) on BMD in patients with glucocorticoid-induced osteoporosis (GIO). In this study, we aimed to evaluate the impact of denosumab on BMD loss in patients with GIO.

Methods
A comprehensive systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. PubMed, Web of Science and Google Scholar were used to search for original studies reported about BMD in patients with GIO treated with denosumab. In meta-analysis of BMD, the mean difference in the rate of change from baseline and the 95% CI were calculated using the random effects model. The mean differences in patients treated with denosumab were compared with those in patients treated with bisphosphonates.

Results
Out of 713 studies identified, seven studies met the selection criteria for the meta-analysis. At 6 and 12 months of denosumab therapy, increases in BMD were observed in the lumbar spine (2.99% [95% CI 2.71, 3.28] and 4.59% [95% CI 4.17, 5.01]), total hip (1.34% [95% CI 0.64, 2.04] and 2.16% [95% CI 2.05, 2.27]) and femoral neck (0.12% [95% CI −0.38, 0.62] and 1.55% [95% CI 0.45, 2.65]). Additionally, denosumab resulted in significant increases in BMD in the lumbar spine and femoral neck at 12 months compared with bisphosphonate therapy.

Conclusion
Patients with GIO experienced significant increases in BMD in response to treatment with denosumab that were detected in the lumbar spine, total hip and femoral neck at 12 months.
Renting Balance Sheet Space: Intermediary Balance Sheet Rental Costs and the Valuation of Derivatives
Authors: Fleckenstein Matthias , Longstaff Francis A 
Published: March 2020

Abstract
A long-standing asset pricing puzzle is that the funding rates in derivatives contracts often differ from those in cash markets. We propose that the cost of renting intermediary balance sheet space may help resolve this puzzle. We study a persistent basis in what is arguably the largest derivatives market, namely, the interest rate futures market. This basis is strongly related to exogenous measures of intermediary balance sheet usage and proxies for the balance sheet costs imposed by debt overhang problems and capital regulation. These results extend to the cash derivatives bases documented in many of the other largest financial markets.
The Forgotten Life of Annie Reay Barker, M.D
Authors: Almond Sophie 
Published: March 2020

Summary
Annie Reay Barker (1851–1945) was a medical pioneer who was amongst the first women to qualify as a doctor in the late nineteenth century. Unlike other medical women of her time, Barker did not attract notable attention or publicity, therefore little has been written about her personal and professional life. Following a successful, yet tragically short-lived, career at the Birmingham and Midland Hospital for Women, Barker was committed to Holloway Sanatorium in Virginia Water with a diagnosis of ‘Chronic Mania’. Barker’s story sheds new light on the pressures placed on early women doctors to succeed, as well as the troubled internal dynamics of this pioneering group of women.
Are arbuscular-mycorrhizal Alnus incana seedlings more resistant to drought than ectomycorrhizal and nonmycorrhizal ones?
Authors: Kilpeläinen Jouni , Aphalo Pedro J , Barbero-López Aitor , Adamczyk Bartosz , Nipu Sammi Alam , Lehto Tarja 
Published: March 2020

Abstract
Arbuscular mycorrhizas (AMs) prevail in warm and dry climates and ectomycorrhizas (EMs) in cold and humid climates. We suggest that the fungal symbionts benefit their host plants especially in the corresponding conditions. The hypothesis tested was that AM plants are more drought-resistant than EM or nonmycorrhizal (NM) plants. Grey alder (Alnus incana (L.) Moench) seedlings were inoculated with two species of either AM or EM fungi or none. In one controlled-environment experiment, there was a watering and a drought treatment. Another set of seedlings were not watered until permanent wilting. The AM plants were somewhat smaller than EM and NM, and at the early stage of the drought treatment, the soil-moisture content was slightly higher in the AM pots. Shoot water potential was highest in the AM treatment during severe drought, while stomatal conductance and photosynthesis did not show a mycorrhizal effect. In the lethal-drought set, the AM plants maintained their leaves longer than EM and NM plants, and the AM seedlings survived longer than NM seedlings. Foliar phosphorus and sulfur concentrations remained higher in AM plants than EM or NM, but potassium, copper and iron increased in EM during drought. The root tannin concentration was lower in AM than EM and drought doubled it. Although the difference in drought resistance was not large, the hypothesis was supported by the better performance of AM plants during a severe short-term drought. Sustained phosphorus nutrition during drought in AM plants was a possible reason for this. Moreover, the higher foliar sulfur and lower metal-nutrient concentrations in AM may reflect differences in nutrient uptake or (re)translocation during drought, which merit further research. The much larger tannin concentrations in EM root systems than AM did not appear to protect the EM plants from drought. The differential tannin accumulation in AM and EM plants needs further attention.
The Pseudomonas aeruginosa product pyochelin interferes with Trypanosoma cruzi infection and multiplication in vitro
Authors: Sass Gabriele , Miller Conrad Laura C , Nguyen Terrence-Thang H , Stevens David A 
Published: March 2020

Abstract

Background
Bacteria are sources of numerous molecules used in treatment of infectious diseases. We investigated effects of molecules produced by 26 Pseudomonas aeruginosa strains against infection of mammalian cell cultures with Trypanosoma cruzi, the aetiological agent of Chagas disease.

Methods
Vero cells were infected with T. cruzi in the presence of wild-type P. aeruginosa supernatants or supernatants of mutants with defects in the production of various virulence, quorum sensing and iron acquisition factors. Quantification of T. cruzi infection (percentage of infected cells) and multiplication (number of amastigotes per infected cell) was performed and cell viability was determined.

Results
Wild-type P. aeruginosa products negatively affected T. cruzi infection and multiplication in a dose-dependent manner, without evident toxicity for mammalian cells. PvdD/pchE mutation (loss of the P. aeruginosa siderophores pyoverdine and pyochelin) had the greatest impact on anti–T. cruzi activity. Negative effects on T. cruzi infection by pure pyochelin, but not pyoverdine, or other P. aeruginosa exoproducts studied, were quantitatively similar to the effects of benznidazole, the current standard therapy against T. cruzi.

Conclusions
The P. aeruginosa product pyochelin showed promising activity against T. cruzi and might become a new lead molecule for therapy development.
Cost Effectiveness of Latest Recommendations for Group B Streptococci Screening in the United States
Authors: Williams Marvin , Zantow Emily , Turrentine Mark 
Published: March 2020

OBJECTIVE:
To evaluate whether group B streptococci (GBS) screening using the 2010 guideline (screening at 35 0/7–37 6/7 weeks of gestation) compared with the 2019 guideline (screening at 36 0/7–37 6/7 weeks of gestation with re-screening of women with GBS-negative results 5 weeks later) was more cost effective.

METHODS:
We constructed a decision-analysis model to compare the outcome of GBS early-onset disease in a hypothetical cohort of 3,614,049 women at 35 0/7 weeks of gestation or greater (the number of live births in 2017 excluding births based on population frequency from 23 to 34 weeks of gestation, women with GBS bacteriuria during the current pregnancy, and those with a history of a previous neonate with GBS disease). We took both a health care and societal perspective and all costs were expressed in 2017 U.S. dollars. Effectiveness was based on neonatal quality-adjusted life years (QALYs) gained. An incremental cost-effectiveness ratio was estimated with a willingness to pay threshold set at $100,000/QALY. All model inputs were derived from the literature. One-way probability and cost sensitivity analysis were performed to investigate model assumptions.

RESULTS:
Screening at 36 0/7–37 6/7 weeks of gestation with re-screening of women with GBS-negative results if 5 weeks passed from culture to delivery resulted in a 6% increase in neonatal QALYs gained (2,162 vs 2,037), 12% fewer cases of neonatal death (30 vs 34), and a 10% estimated reduction in total societal health care expenditures related to GBS early-onset disease ($639 million vs $707 million) when compared with the 2010 strategy of only screening at 35 0/7–37 6/7 weeks of gestation. The 2019 approach was cost effective, with an incremental cost-effectiveness ratio of $43,205 per neonatal QALY gained.

CONCLUSION:
Screening at 36 0/7–37 6/7 weeks of gestation with a 5-week re-screening for women with GBS-negative results is more cost effective than past strategies used in the United States.