bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application and Effectiveness of Play Therapy Using an Online-Game Intervention for Hidden Youth
Authors: Chan Gloria Hongyee 
Published: October 2019

AbstractBased on the view that hidden youth suffer from disempowerment in society due to their inability to meet mainstream expectations, this study explores an alternative intervention approach for hidden youth by using an online gaming platform to provide Play Therapy. This empowered them and coincides with their culture and interests. The evaluative study of the effectiveness of the intervention involved 502 hidden youth in Hong Kong aged twelve to twenty-one years, of whom more than 70 per cent spent at least ten hours online per day. Correlation analysis and hierarchical regression analysis were conducted to measure the effectiveness of Play Therapy in terms of the empowerment effect, as well as participants’ sense of well-being and coping abilities (psychological capital). Results showed that the three variables were significantly related. Also, while Play Therapy significantly predicted psychological capital in the Level 2 regression model, this relationship was replaced by empowerment in the Level 3 model. This suggests that empowerment is an essential element in Play Therapy for enhancing psychological capital. The implication for social work practice is, rather than re-integrating youth into disempowering mainstream society, practitioners can advocate empowering, localised intervention which unfolds youth’s subjugated strengths and nurtures their self-preferred development to fulfil their developmental needs.
Climatic affinities of Neotropical species of Capparaceae: an approach from ecological niche modelling and numerical ecology
Authors: Mercado Gómez Jorge D , Prieto-Torres David A , Gonzalez Maylin Adriana , Morales Puentes María Eugenia , Escalante Tania , Rojas-Soto Octavio 
Published: October 2019

Abstract
In the Neotropics, the distribution of Capparaceae has been historically associated with seasonally dry forest (NSDF), but recent taxonomic studies have questioned this assumption. Given the environmental co-occurrence of species and the need to understand their relationships with the ecosystem, we use ecological niche modelling and numerical ecology methods to better describe the distribution patterns of Capparaceae and their climatic affinities with NSDF. We used the Maxent algorithm to model the ecological niches of 104 species of Capparaceae, which gave maximum values of the response curves for climatic suitability. These values were used to carry out multivariate statistical analyses [principal components analysis (PCA), non-metric multidimensional scaling (NMDS) and discriminant analysis (DA)] to identify ecological associations based on climatic similitude among species. Both PCA and NMDS showed that annual precipitation, precipitation of the wettest quarter and precipitation of the driest quarter were the most important climatic variables shaping distributions of species and their associations with NSDF, moist tropical forest (MTF) and wet tropical forest (WTF). Although we found 72 species associated with NSDF as previously reported, DA revealed an overlapping pattern among the three ecological/climatic assemblages (NSDF, MTF and WTF). This confirms the existence of transition zones and species with wider niches. Our results provide an important biogeographical framework of ecological patterns for species associated with NSDF, opening new lines of research on the reconstruction of distribution in future climatic scenarios or palaeo-distributions.
Cryptococcal Antigenemia in Human Immunodeficiency Virus Antiretroviral Therapy–Experienced Ugandans With Virologic Failure
Authors: Mpoza Edward , Rajasingham Radha , Tugume Lillian , Rhein Joshua , Nabaggala Maria Sarah , Ssewanyana Isaac , Nyegenye Wilson , Kushemererwa Grace Esther , Mulema Vivienne , Kalamya Julius , Kiyaga Charles , Kabanda Joseph , Ssali Mina , Boulware David R , Meya David B 
Published: October 2019

Abstract

Background
Detectable serum or plasma cryptococcal antigen (CrAg) precedes symptomatic cryptococcal meningitis. The World Health Organization recommends CrAg screening for human immunodeficiency virus–positive persons with CD4 count &lt;100 cells/μL initiating antiretroviral therapy (ART). However, an increasing proportion of patients with cryptococcosis are now ART experienced. Whether CrAg screening is cost-effective in those with virologic failure is unknown.

Methods
We retrospectively performed nationwide plasma CrAg testing among ART-experienced Ugandan adults with virologic failure (≥1000 copies/mL) using leftover plasma after viral load testing during September 2017–January 2018. For those who were CrAg positive, we obtained ART history, meningitis occurrence, and 6-month survival via medical records review.

Results
Among 1186 subjects with virologic failure, 35 (3.0%) were CrAg positive with median ART duration of 41 months (interquartile range, 10–84 months). Among 25 subjects with 6-month outcomes, 16 (64%) survived, 7 (28%) died, and 2 (8%) were lost. One survivor had suffered cryptococcal meningitis 2 years prior. Two others developed cryptococcal meningitis and survived. Five survivors were known to have received fluconazole. Thus, meningitis-free survival at 6 months was 61% (14/23). Overall, 91% (32/35) of CrAg-positive persons had viral load ≥5000 copies/mL compared with 64% (735/1151) of CrAg-negative persons (odds ratio, 6.0 [95% confidence interval, 1.8–19.8]; P = .001). CrAg prevalence was 4.2% (32/768) among those with viral loads ≥5000 copies/mL and 0.7% (3/419) among those with viral loads &lt;5000 copies/mL.

Conclusions
In addition to the CD4 threshold of &lt;100 cells/μL, reflexive CrAg screening should be considered in persons failing ART in Uganda with viral loads ≥5000 copies/mL.
Demand-led growth and accommodating supply
Authors: Fazzari Steven M , Ferri Piero , Variato Anna Maria 
Published: October 2019

Abstract
We model of demand-led growth with endogenous adjustment of labour supply and productivity, an approach that reconciles Harrod’s warranted rate of demand growth with supply. The model delivers a range of growth paths and unemployment rates rather than a single ‘natural rate’. Theoretically, the steady-state growth path may be dynamically stable or unstable, but empirical calibration favours stability. We show analytically that if demand dynamics are stable, supply will converge to the demand-determined growth path. While a minimum unemployment rate ultimately imposes a supply constraint on growth, empirical results show that a wide range of growth rates are feasible across different demand regimes. The results explain how economies can become trapped with low growth due to weak demand or fiscal austerity and suggest policy responses to stagnant demand.
On the ‘utilisation controversy’: a comment
Authors: Gahn Santiago José , González Alejandro 
Published: October 2019

AbstractIn a recent contribution, Nikiforos (Nikiforos, M. 2016. On the utilisation controversy: a theoretical and empirical discussion of the Kaleckian model of growth and distribution, Cambridge Journal of Economics, vol. 40, no. 2, 437–67) has claimed that the FED data on capacity utilisation are stationary by construction, and thus, not suitable to test the Neo-Kaleckian model. He then proceeds to provide new series on capital utilisation, which he claims are non-stationary and provide, supposedly, support for the Neo-Kaleckian model. This comment presents two interrelated claims. First, the measurement error that Nikiforos claims to be I(1) in the FED series is I(0), and what is measured with error is only the level of the series. Thus, this series is suitable to test the Neo-Kaleckian model. Secondly, he does not provide unit root tests for the series he suggests as superior to the FED. When this exercise is carried out, almost all unit root tests decidedly reject the existence of a stochastic trend on his three proposed series, which, according to the author, do not lend support to the Neo-Kaleckian model. We conclude that measures of capacity utilisation based on FRB data are a reasonable source to test the implications of a wide variety of macroeconomic models.
Climatic effects and total factor productivity: econometric evidence for Wisconsin dairy farms
Authors: Njuki Eric , Bravo-Ureta Boris E , Cabrera Víctor E 
Published: October 2019

AbstractThis study exploits temporal and cross-sectional variation in weather and long-run climate trends to investigate their effects on farm-level productivity. Using panel data for a sample of Wisconsin dairy producers, three stochastic production frontier models are estimated and a random parameters approach is chosen as the most desirable, which accounts for stochastic observed and unobserved environmental factors. The estimated coefficients are used to decompose a multiplicative total factor productivity index that accounts for different sources of productivity growth. Annual productivity growth is estimated at 2.16 per cent, driven primarily by technical progress (1.91 per cent per annum). The average per year contribution of the other productivity components is: climate adaptation efforts −0.31 per cent; scale-mix efficiency change +0.13 per cent and technical efficiency +0.05 per cent.
Faecal immunochemical test-based colorectal cancer screening in Mexico: an initial experience
Authors: Remes-Troche José María , Hinojosa-Garza Gabriela , Espinosa-Tamez Priscilla , Meixueiro-Daza Arturo , Grube-Pagola Peter , Van Loon Katherine , Potter Michael B , Lajous Martin 
Published: October 2019

Abstract

Background
In middle-income countries, the burden of colorectal cancer (CRC) is increasing in parallel with resources for diagnosis and treatment. There is a potential benefit of CRC screening programs in Mexico.

Objective
Since there are no organized screening programs in the country, we explored the willingness of individuals to complete a faecal immunochemical testing (FIT) based CRC screening program and its potential benefit in Mexico.

Methods
We conducted a CRC screening program pilot in Veracruz, Mexico, during 2015–16 using FIT. Individuals with FIT results &gt;100 ng of haemoglobin/ml buffer were referred for diagnostic colonoscopy.

Results
Of 473 FIT kits distributed to adults aged 50–75, 85.8% (406) were completed by participants and analysed in the laboratory. Of these, 5.9% (24/406) of test results showed &gt;100 ng haemoglobin/ml. Twenty-one participants completed colonoscopy. The positive predictive value of FIT &gt;100 ng haemoglobin/ml for premalignant lesions was 33%.

Conclusion
These results provide preliminary evidence of the willingness of individuals to complete FIT-based CRC screening program in Mexico. However, further evaluation of health systems resources will be needed prior to large-scale implementation of CRC screening programs.
Enrichment and isolation of acid-tolerant sulfate-reducing microorganisms in the anoxic, acidic hot spring sediments from Copahue volcano, Argentina
Authors: Willis Graciana , Nancucheo Ivan , Hedrich Sabrina , Giaveno Alejandra , Donati Edgardo , Johnson David Barrie 
Published: October 2019

ABSTRACTThe geothermal Copahue-Caviahue (GCC) system (Argentina) is an extreme acidic environment, dominated by the activity of Copahue volcano. Environments characterised by low pH values, such as volcanic areas, are of particular interest for the search of acidophilic microorganisms with application in biotechnological processes. In this work, sulfate-reducing microorganisms were investigated in geothermal acidic, anaerobic zones from GCC system. Sediment samples from Agua del Limón (AL1), Las Máquinas (LMa2), Las Maquinitas (LMi) and Baño 9 (B9–2, B9–3) were found to be acidic (pH values 2.1–3.0) to moderate acidic (5.1–5.2), containing small total organic carbon values, and ferric iron precipitates. The organic electron donor added to the enrichment was completely oxidised to CO2. Bacteria related to ‘Desulfobacillus acidavidus’ strain CL4 were found to be dominant (67–83% of the total number of clones) in the enrichment cultures, and their presence was confirmed by their isolation on overlay plates. Other bacteria were also detected with lower abundance (6–20% of the total number of clones), with representatives of the genera Acidithiobacillus, Sulfobacillus, Alicyclobacillus and Athalassotoga/Mesoaciditoga. These enrichment and isolates found at low pH confirm the presence of anaerobic activities in the acidic sediments from the geothermal Copahue-Caviahue system.
Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis
Authors: Liu Yuanjun , Hu Chunmin , Sun Yina , Wu Haoqing , Chen Xiaojun , Liu Quanzhong 
Published: October 2019

ABSTRACT
Non-coding circular RNAs (circRNAs) have been shown to have important roles in many diseases; however, no study has indicated circRNAs are involved in Chlamydia trachomatis infection. In this study, we used circRNA microarray to measure the global circRNA expression profiles in HeLa cells with or without C. trachomatis serovar E (Ct.E) infection. CircRNA/miRNA/mRNA interactions were predicted and bioinformatics analyses were performed. The differentially expressed circRNAs were selected according to our criterion for validation by reverse-transcription and quantitative polymerase chain reaction (RT-qPCR). The mRNA microarray was used to detect the mRNA expression profiles after Ct.E infection. Among 853 differentially expressed circRNAs, 453 were upregulated and 400 were downregulated after Ct.E infection. Target miRNAs and miRNA-targeted mRNAs of these circRNAs were predicted. RT-qPCR analysis indicated hsa_circRNA_001226, hsa_circRNA_007046 and hsa_circRNA_400027 were elevated similar to those determined in the circRNA microarray analysis. The mRNA microarray results showed 915 genes were upregulated and 619 genes were downregulated after Ct.E infection. Thirty-four differentially expressed genes overlapped in the bioinformatics and mRNA microarray results. KEGG pathway analysis revealed several signaling pathways, including endocytosis, MAPK and PI3P-Akt signaling pathways, that were targeted by circRNAs may play important roles in Chlamydia infection. This study provides evidence that circRNAs in host cells are involved in the process of Chlamydia infection.
The relationship between resourceful working conditions, work-related and general sense of coherence
Authors: Broetje Sylvia , Bauer Georg F , Jenny Gregor J 
Published: October 2019

Abstract
Sense of coherence (SoC) has been identified as an important health resource and is associated with various health-related outcomes, especially perceived health and mental health. SoC has also been found to be relevant in the work context. Our study examined whether job resources, such as autonomy or social support, can contribute to the development of SoC. We also examined the role of the setting-specific work-related sense of coherence (Work-SoC) as well as reciprocal relationships between the three variables. Participants (941) from Germany, Switzerland and Austria completed our questionnaires at three waves of data collection. Structural equation modeling was used to identify the best fitting model and interpret the relationships between variables. Our first hypothesis that job resources predict Work-SoC and that Work-SoC predicts SoC was confirmed. We also found support for our second hypothesis that SoC predicts Work-SoC and that Work-SoC predicts job resources. The indirect effects through Work-SoC were only marginally significant in both directions. Our findings illustrate complex and multidirectional relationships between the variables. Job resources seem to contribute to the strengthening of Work-SoC, which seems to set in motion a gain cycle of improved job resources, which again contribute to a higher Work-SoC. Over time, this might contribute to strengthening general SoC. However, our findings showed that SoC was highly stable over the observed 3-month interval, limiting the effect any other variable could exert on it. Future research should further examine the mechanisms and timeframes over which a setting-specific SoC contributes to the development of overall SoC.
The effects of hyaluronate-containing medium on human embryo attachment to endometrial epithelial cells in vitro
Authors: Ruane Peter T , Buck Chelsea J , Babbington Phoebe A , Aboussahoud Wedad , Berneau Stéphane C , Westwood Melissa , Kimber Susan J , Aplin John D , Brison Daniel R 
Published: October 2019

Abstract

STUDY QUESTION
Does embryo transfer medium containing hyaluronate (HA) promote the attachment phase of human embryo implantation?

SUMMARY ANSWER
HA-containing medium does not promote human blastocyst attachment to endometrial epithelial cells in vitro.

WHAT IS KNOWN ALREADY
Embryo transfer media containing high concentrations of HA are being used to increase implantation and live birth rates in IVF treatment, although the mechanism of action is unknown.

STUDY DESIGN, SIZE, DURATION
Expression of HA-interacting genes in frozen-thawed oocytes/embryos was assessed by microarray analysis (n = 21). Fresh and frozen human blastocysts (n = 98) were co-cultured with human endometrial epithelial Ishikawa cell layers. Blastocyst attachment and the effects of a widely used HA-containing medium were measured.

PARTICIPANTS/MATERIALS, SETTING, METHODS
Human embryos surplus to treatment requirements were donated with informed consent from several ART centres. Blastocyst-stage embryos were transferred at day 6 to confluent Ishikawa cell layers; some blastocysts were artificially hatched. Blastocyst attachment was monitored from 1 to 48 h, and the effects of blastocyst pre-treatment for 10 min with HA-containing medium were determined.

MAIN RESULTS AND THE ROLE OF CHANCE
Human embryos expressed the HA receptor genes CD44 and HMMR, hyaluronan synthase genes HAS1–3, and hyaluronidase genes HYAL1–3, at all stages of preimplantation development. Attachment of partially hatched blastocysts to Ishikawa cells at 24 and 48 h was related to trophectoderm grade (P = 0.0004 and 0.007, respectively, n = 34). Blastocysts of varying clinical grades that had been artificially hatched were all attached within 48 h (n = 21). Treatment of artificially hatched blastocysts with HA-containing medium did not significantly affect attachment at early (1–6 h) or late (24 and 48 h) time points, compared with control blastocysts (n = 43).

LIMITATIONS, REASONS FOR CAUTION
Using an adenocarcinoma-derived cell line to model embryo-endometrium attachment may not fully recapitulate in vivo interactions. The high levels of blastocyst attachment seen with this in vitro model may limit the sensitivity with which the effects of HA can be observed.

WIDER IMPLICATIONS OF THE FINDINGS
Morphological trophectoderm grade can be correlated with blastocyst attachment in vitro. HA-containing medium may increase pregnancy rates by mechanisms other than promoting blastocyst attachment to endometrium.

STUDY FUNDING/COMPETING INTEREST(S)
This work was funded by a grant from the Wellbeing of Women, the NIHR Local Comprehensive Research Network and NIHR Manchester Clinical Research Facility, the Department of Health Scientist Practitioner Training Scheme, and the Ministry of Higher Education, The State of Libya. None of the authors has any conflict of interest to declare.
Household structure, maternal characteristics and children’s stunting in sub-Saharan Africa: evidence from 35 countries
Authors: Yaya Sanni , Oladimeji Olanrewaju , Odusina Emmanuel Kolawole , Bishwajit Ghose 
Published: October 2019

Abstract

Background
Adequate nutrition in early childhood is a necessity to achieve healthy growth and development, as well as a strong immune system and good cognitive development. The period from conception to infancy is especially vital for optimal physical growth, health and development. In this study we examined the influence of household structure on stunting in children &lt;5 yrs of age in sub-Saharan Africa (SSA) countries.

Methods
Demographic and Health Survey data from birth histories in 35 SSA countries were used in this study. The total sample of children born within the 5 yrs before the surveys (2008 and 2018) was 384 928. Children whose height-for-age z-score throughout was &lt;−2 SDs from the median of the WHO reference population were considered stunted. Percentages and χ2 tests were used to explore prevalence and bivariate associations of stunting. In addition, a multivariable logistic regression model was fitted to stunted children. All statistical tests were conducted at a p&lt;0.05 level of significance.

Results
More than one-third of children in SSA countries were reportedly stunted. The leading countries include Burundi (55.9%), Madagascar (50.1%), Niger (43.9%) and the Democratic Republic of the Congo (42.7%). The percentage of stunted children was higher among males than females and among rural children than their urban counterparts in SSA countries. Children from polygamous families and from mothers who had been in multiple unions had a 5% increase in stunting compared with children from monogamous families and mothers who had only one union (AOR 1.05 [95% CI 1.02 to 1.09]). Furthermore, rural children were 1.23 times as likely to be stunted compared with urban children (AOR 1.23 [95% CI 1.16 to 1.29]). Children having a &lt;24-mo preceding birth interval were 1.32 times as likely to be stunted compared with first births (AOR 1.32 [95% CI 1.26 to 1.38]). In addition, there was a 2% increase in stunted children for every unit increase in the age (mo) of children (AOR 1.02 [95% CI 1.01 to 1.02]). Multiple-birth children were 2.09 times as likely to be stunted compared with a singleton (AOR 2.09 [95% CI 1.91 to 2.28]).

Conclusions
The study revealed that more than one-third of children were stunted in SSA countries. Risk factors for childhood stunting were also identified. Effective interventions targeting factors associated with childhood stunting, such as maternal education, advanced maternal age, male sex, child’s age, longer birth interval, multiple-birth polygamy, improved household wealth and history of mothers’ involvement in multiple unions, are required to reduce childhood stunting in the region.