bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel rare c.-39C&gt;T mutation in the PROS1 5′UTR causing PS deficiency by creating a new upstream translation initiation codon
Authors: Labrouche-Colomer Sylvie , Soukarieh Omar , Proust Carole , Mouton Christine , Huguenin Yoann , Roux Maguelonne , Besse Céline , Boland Anne , Olaso Robert , Constans Joël , Deleuze Jean-François , Morange Pierre-Emmanuel , Jaspard-Vinassa Béatrice , Trégouët David-Alexandre ,   on behalf of the GenMed Consortium
Published: May 2020

AbstractAutosomal dominant inherited Protein S deficiency (PSD) (MIM 612336) is a rare disorder caused by rare mutations, mainly located in the coding sequence of the structural PROS1 gene, and associated with an increased risk of venous thromboembolism. To identify the molecular defect underlying PSD observed in an extended French pedigree with seven PSD affected members in whom no candidate deleterious PROS1 mutation was detected by Sanger sequencing of PROS1 exons and their flanking intronic regions or via an multiplex ligation-dependent probe amplification (MLPA) approach, a whole genome sequencing strategy was adopted. This led to the identification of a never reported C to T substitution at c.-39 from the natural ATG codon of the PROS1 gene that completely segregates with PSD in the whole family. This substitution ACG→ATG creates a new start codon upstream of the main ATG. We experimentally demonstrated in HeLa cells that the variant generates a novel overlapping upstream open reading frame (uORF) and inhibits the translation of the wild-type PS. This work describes the first example of 5′UTR PROS1 mutation causing PSD through the creation of an uORF, a mutation that is not predicted to be deleterious by standard annotation softwares, and emphasizes the need for better exploration of such type of non-coding variations in clinical genomics.
Three‐phase interleaved high step‐up bidirectional DC–DCconverter
Authors: Wang Fan , Wang Yubin , Su Bing , Teng Changpeng 
Published: May 2020

A three‐phase interleaved high step‐up bidirectional DC–DC converter is proposed, which can achieve three times the voltage gain of the traditional three‐phase interleaved boost converter only by adding two capacitors. The proposed converter has the characteristics of low switch voltage and current stresses, low output voltage ripple, automatic voltage‐balancing and current‐sharing abilities. Compared with the traditional interleaved switching strategy, a 180° interleaved switching strategy is proposed, which is more suitable for the proposed converter by widening the working duty cycle range. Closed dual‐loop control is used to regulate the output voltage of the converter. The parameter determining the method of the closed‐loop controllers based on the Bode diagram is described in order to control the high‐order converter. Operating principle, modelling, steady‐state analysis, voltage‐balancing and current‐sharing ability analysis and closed‐loop design of the converter are studied in more detail. Finally, experimental verification and efficiency measurements are implemented by a 300 W, 24 V input to 230 V DC bus prototype, which proved that the proposed converter is more suitable than the traditional three‐phase interleaved boost converter for some applications where requiring about six to ten times the voltage conversion ratio.
Multiconfiguration Dirac-Hartree-Fock calculations of Landég-factors for ions of astrophysical interest: B II, C I−IV, Al I−II, Si I−IV, P II, S II, Cl III, Ar IV, Ca I, Ti II, Zr III, and Sn II
Authors: Li W. , Rynkun P. , Radžiūtė L. , Gaigalas G. , Atalay B. , Papoulia A. , Wang K. , Hartman H. , Ekman J. , Brage T. , Chen C. Y. , Jönsson P. 
Published: May 2020

Aims.The Landég-factor is an important parameter in astrophysical spectropolarimetry, used to characterize the response of a line to a given value of the magnetic field. The purpose of this paper is to present accurate Landég-factors for states in B II, C I−IV, Al I−II, Si I−IV, P II, S II, Cl III, Ar IV, Ca I, Ti II, Zr III, and Sn II.Methods.The multiconfiguration Dirac-Hartree-Fock and relativistic configuration interaction methods, which are implemented in the general-purpose relativistic atomic structure package GRASP2K, are employed in the present work to compute the Landég-factors for states in B II, C I−IV, Al I−II, Si I−IV, P II, S II, Cl III, Ar IV, Ca I, Ti II, Zr III, and Sn II. The accuracy of the wave functions for the states, and thus the accuracy of the resulting Landég-factors, is evaluated by comparing the computed excitation energies and energy separations with the National Institute of Standards and Technology (NIST) recommended data.Results.All excitation energies are in very good agreement with the NIST values except for Ti II, which has an average difference of 1.06%. The average uncertainty of the energy separations is well below 1% except for the even states of Al I; odd states of Si I, Ca I, Ti II, Zr III; and even states of Sn II for which the relative differences range between 1% and 2%. Comparisons of the computed Landég-factors are made with available NIST data and experimental values. Analysing theLS-composition of the wave functions, we quantify the departures fromLS-coupling and summarize the states for which there is a difference of more than 10% between the computed Landég-factor and the Landég-factor in pureLS-coupling. Finally, we compare the computed Landég-factors with values from the Kurucz database.
Chamäleonartige Hornhautveränderungen: Akanthamöbenkeratitis
Authors: Szentmáry Nóra , Fries Fabian Norbert , Daas Loay , Shi Lei , Laurik Kornelia Lenke , Langenbucher Achim , Seitz Berthold 
Published: May 2020

ZusammenfassungDie Akanthamöbenkeratitis ist ein „Chamäleon“. Sie präsentiert sich klassischerweise mit gräulichen Epithelveränderungen, Perineuritis, oberflächlichen multifokalen stromalen Infiltraten und Ringinfiltrat. Bei klinischem Verdacht auf Akanthamöbenkeratitis ist eine Polymerase-Ketten-Reaktion, eine Kultivierung oder die histopathologische Untersuchung zur Diagnosestellung notwendig. Die konfokale Mikroskopie hat sich als noninvasive Ad-hoc-Diagnostik bei Initialverdacht instituiert.
Posttraumatische Belastungsstörung in der digitalen Arbeitswelt
Authors: Kreutzer Lili , Köllner Volker 
Published: May 2020

ZusammenfassungWir berichten über einen 36-jährigen Patienten, welcher nach einer beruflichen Konfrontation mit Darstellungen von Gewalt an Tieren, sexueller Gewalt sowie körperlicher Gewalt über digitale Medien in seiner Position als social media content moderator die klassischen Symptome einer PTBS entwickelte.Nach 10 monatiger Arbeitsunfähigkeit kam der Patient zur sozialmedizinischen Einschätzung zur Rehabilitation. Obwohl aufgrund der hohen Resilienz und Motivationslage des Patienten von einer Regeneration binnen der kommenden 6 Monate und einer Neuorientierung auf dem Allgemeinen Arbeitsmarkt ausgegangen wurde, wurde seine Leistungsfähigkeit hinsichtlich seiner letzten sozialversicherungspflichtigen Tätigkeit vollständig aufgehoben eingeschätzt.Diese sekundäre, digitale Art der Traumatisierung ist in der aktuell gültigen Version des ICD-10 nicht aufgeführt, wird aber bereits in den A4 Kriterien des DSM-5 beschrieben. Hier wird eine Exposition über elektronische Instrumente, Television, Filme oder Fotografien ausgeschlossen, es sei denn die Exposition ist beruflich bedingt.Anhand dieses Beispiels werden Risiken für die mentale Gesundheit durch digitale Faktoren während der Arbeit, sowie deren sozialmedizinischen und versicherungstechnischen Folgen dargestellt.
Preoperative Dutasteride Use has no effect on Intraoperative Bleeding during Transvesical Open Simple Prostatectomy for Benign Prostatic Hyperplasia
Authors: Guner Ekrem , Ugur Ramazan 
Published: May 2020

Abstract
Objective There are a few studies in the literature investigating the effect of preoperative dutasteride use on bleeding in open simple prostatectomy. We aimed to evaluate the effect of preoperative dutasteride use on perioperative bleeding during open simple prostatectomy.
Methods We retrospectively analyzed the medical records of all patients who underwent transvesical open prostatectomy due to benign prostatic hyperplasia in our institution between 2008 and 2018. Patients were divided into 2 groups regarding the use of dutasteride prior to surgery as group 1 = received dutasteride during at least six weeks prior to surgery; group 2 = dutasteride naive.Results: A total of 167 patients who met the inclusion criteria were included in the study. The mean operative time was 86.5±18.7 min while the estimated blood loss was 640.7±55.7 ml. There was no statistically significant difference in operative time, estimated blood loss, hemoglobin, and hematocrit decrease among the two groups.
Conclusion We were not able to find an advantage of pre-operative dutasteride use in terms of perioperative bleeding in open simple prostatectomy performed for benign prostatic hyperplasia.
Personal Protective Equipment during Endoscopy
Authors: Mathew Shibi , Philip Mathew 
Published: May 2020

AbstractThe novel coronavirus disease 2019 (COVID-19) which originated in China has been declared a pandemic by the World Health Organization (WHO). This virus gets transmitted through air droplets and direct contact. Health care workers doing aerosol-generating procedures are at a higher risk of acquiring the infection. Many procedures done by the gastrointestinal endoscopists are classified as aerosol-generating procedures, which in turn underline the need for proper safety precautions during these procedures. Apart from general safety measures advised by various organizations, proper use of personal protective equipment (PPE) is a pivotal factor in safeguarding health care personnel during endoscopy. This article provides a short overview of the different PPEs available and their proper use in endoscopy.
Population transfer to high angular momentum states in infrared-assisted XUV photoionization of helium
Authors: Mayer Nicola , Peng Peng , Villeneuve David M , Patchkovskii Serguei , Ivanov Misha , Kornilov Oleg , Vrakking Marc J J , Niikura Hiromichi 
Published: May 2020

Abstract
An extreme-ultraviolet (XUV) laser pulse consisting of harmonics of a fundamental near-infrared (NIR) laser frequency is combined with the NIR pulse to systematically study two-color photoionization of helium atoms. A time-resolved photoelectron spectroscopy experiment is carried out where energy- and angle-resolved photoelectron distributions are obtained as a function of the NIR intensity and wavelength. Time-dependent Schrödinger equation calculations are performed for the conditions corresponding to the experiment and used to extract residual populations of Rydberg states resulting from excitation by the XUV + NIR pulse pair. The residual populations are studied as a function of the NIR intensity (3.5 × 1010 − 8 × 1012 W cm−2) and wavelength (760–820 nm). The evolution of the photoelectron distribution and the residual populations are interpreted using an effective restricted basis model, which includes the minimum set of states relevant to the features observed in the experiments. As a result, a comprehensive and intuitive picture of the laser-induced dynamics in helium atoms exposed to a two-color XUV–NIR light field is obtained.
New physics searches with heavy-ion collisions at the CERN Large Hadron Collider
Authors: Bruce Roderik , d’Enterria David , de Roeck Albert , Drewes Marco , Farrar Glennys R , Giammanco Andrea , Gould Oliver , Hajer Jan , Harland-Lang Lucian , Heisig Jan , Jowett John M , Kabana Sonia , Krintiras Georgios K , Korsmeier Michael , Lucente Michele , Milhano Guilherme , Mukherjee Swagata , Niedziela Jeremi , Okorokov Vitalii A , Rajantie Arttu , Schaumann Michaela 
Published: May 2020

Abstract
This document summarises proposed searches for new physics accessible in the heavy-ion mode at the CERN Large Hadron Collider (LHC), both through hadronic and ultraperipheral γγ interactions, and that have a competitive or, even, unique discovery potential compared to standard proton–proton collision studies. Illustrative examples include searches for new particles—such as axion-like pseudoscalars, radions, magnetic monopoles, new long-lived particles, dark photons, and sexaquarks as dark matter candidates—as well as new interactions, such as nonlinear or non-commutative QED extensions. We argue that such interesting possibilities constitute a well-justified scientific motivation, complementing standard quark-gluon-plasma physics studies, to continue running with ions at the LHC after the Run-4, i.e. beyond 2030, including light and intermediate-mass ion species, accumulating nucleon–nucleon integrated luminosities in the accessible fb−1 range per month.
Remote sensing and electromagnetic wave behaviour to measure vegetation phenology with physics
Authors: Woźniak Edyta , Gabryszewski Ryszard , Dziob Daniel 
Published: May 2020

Abstract
Interdisciplinary models of teaching have been present in education systems for at least 30 years. The idea of the interdisciplinarity is to show students the contextualisation of subject knowledge, its relation to real-life problems and to build skills across traditional disciplinary boundaries. This is essential to future competitiveness since innovations frequently occur at the interface of disciplines when people are able to collaborate. Schools try to respond to the need to prepare students for an interdisciplinary and collaborative job market by modifying the curricula and training teachers. But one of the most primary and difficult problems is preparing a truly interdisciplinary lesson or a project. It seems that all complex issues could be good examples for this purpose. One of these complex issues is the study of climate change, which requires the collaboration of different specialists and a comprehensive understanding of the problem in different scientific fields: physical, geographical, biological, social, engineering, etc. The paper presents an interdisciplinary project which links knowledge within a few different science areas around the real-life problem important for students. The work shows the developed and tested interdisciplinary educational project ‘Panta Rhei’ which integrates physics and other STEM subjects to present the biological and social consequences of changes in vegetation periods for different climate zones. It shows how Earth observation research can be utilised in schools for teaching physics and other science subjects. The project was validated on a group of Polish teachers. In the paper we present the whole project together with teachers' opinions.
A teaching module for blackbody radiation using the continuous
spectra of stars
Authors: Kardaras Ioannis , Kallery Maria 
Published: May 2020

Abstract
Teaching blackbody radiation within the framework of astrophysics can motivate
students to learn and obtain a more profound and qualitative understanding of
the subject. In this paper we present a teaching module that intertwines
teaching blackbody radiation via the continuous spectrum of hot objects,
especially the stars. The module’s approach was that of guided inquiry.
Students of upper secondary education carried out experimental activities that
included a combination of hands-on activities and computer processing. They
actively and creatively engaged in the activities which helped them develop a
more complex and structured knowledge of the subject. A ten-multiple choice
questionnaire was administered before and after the implementation and the data
were qualitatively and quantitatively analyzed. The results showed that the
intervention had a significant impact on students’ learning outcomes.
Our twinkling sun
Authors: Haigh David , Hikmet Hussein Ahmed , Moore Andrew , Hughes Jennifer 
Published: May 2020

Abstract
It is well known that the twinkling of stars in the night sky is due to
turbulence within the earth’s atmosphere causing localised fluctuations in
refractive index. The paper describes a method for demonstrating the effect to
learners during the daytime. This is accomplished by detecting audio frequency
fluctuations in the level of direct sunlight and then presenting the result via
headphones or a loudspeaker. The paper makes several suggestions for further
work and potential applications of the technique in different fields of study
are discussed.
An open-loop control algorithm of the active reflector system of FAST
Authors: Li Hui , Jiang Peng 
Published: May 2020

Abstract
An open-loop control algorithm is put forward for continuous paraboloid deformation of the active reflector system of the Five-hundred-meter Aperture Spherical radio Telescope (FAST). The method is based on a calibration database and interpolation in 2D spatial domain and temperature domain, respectively. It is completely independent of real-time measurement of cable nodes so that it has advantage of working all-weather and no additional electro-magnetic interference (EMI). Furthermore, its control accuracy can be effectively improved via reasonable layout of the calibrated paraboloids and increasing calibration accuracy. Meanwhile deformation safety is considered via calibration as well. Finally its control accuracy is also confirmed via site measurements of paraboloid deformations.
FAST VLBI: current status and future plans
Authors: Chen Ru-Rong , Zhang Hai-Yan , Jin Cheng-Jin , Gao Zhi-Shen , Zhu Yan , Zhu Kai , Jiang Peng , Yue You-Ling , Lu Ji-Guang , Zhang Bo , Jiang Wu , Zhu Ren-Jie , Guo Shao-Guang , Xia Bo , Zhao Rong-Bing , Collaboration FAST 
Published: May 2020

Abstract
The Five-hundred-meter Aperture Spherical radio Telescope (FAST) is the largest single-dish radio telescope in the world, and is now being commissioned after the first light in September 2016. Very long baseline interferometry (VLBI) is among the key science topics according to the original design. The FAST VLBI system has been established, and the first VLBI fringe has been successfully obtained. FAST will significantly improve the sensitivity of the existing VLBI networks in the future, and some science projects in need of high sensitivity will benefit from its participation.
HI hydrolysis-derived intermediate as booster for CsPbI3 perovskite: from crystal structure, film fabrication to device performance
Authors: Li Zhizai , Jin Zhiwen 
Published: May 2020

Abstract
Nowadays, inorganic CsPbI3 perovskite solar cells (PSCs) have become one of the most attractive research hotspots in photovoltaic field for its superior chemical stability and excellent photo-electronic properties. Since the first independent report in 2015, the power conversion efficiency (PCE) of CsPbI3 based PSCs has sharply increased from 3.9% to 19.03%. Importantly, during the developing process of CsPbI3 PSCs, HI hydrolysis-derived intermediate plays an important role: from stabilizing the crystal structure, optimizing the fabricated film to boosting the device performance. In this review, the different crystal and electronic structures of CsPbI3 are introduced. We then trace the history and disputes of HI hydrolysis-derived intermediate to make this review more logical. Meanwhile, we highlight the functions of HI hydrolysis-derived intermediate, and systematically summarize the advanced works on CsPbI3 PSCs. Finally, the bottlenecks and prospects are revealed to further increase the CsPbI3 PSCs performance.
The strategies for preparing blue perovskite light-emitting diodes
Authors: Lu Jianxun , Wei Zhanhua 
Published: May 2020

Abstract
Metal halide perovskites have attracted tremendous interest due to their excellent optical and electrical properties, and they find many promising applications in the optoelectronic fields of solar cells, light-emitting diodes, and photodetectors. Thanks to the contributions of international researchers, significant progress has been made for perovskite light-emitting diodes (Pero-LEDs). The external quantum efficiencies (EQEs) of Pero-LEDs with emission of green, red, and near-infrared have all exceeded 20%. However, the blue Pero-LEDs still lag due to the poor film quality and deficient device structure. Herein, we summarize the strategies for preparing blue-emitting perovskites and categorize them into two: compositional engineering and size controlling of the emitting units. The advantages and disadvantages of both strategies are discussed, and a perspective of preparing high-performance blue-emitting perovskite is proposed. The challenges and future directions of blue Pero-LEDs fabrication are also discussed.
Mo5+ doping induced interface polarization for improving performance of planar perovskite solar cells
Authors: Jiang Yurong , Yang Yue , Liu Yiting , Yan Shan , Feng Yanxing , Xia Congxin 
Published: May 2020

Abstract
In this paper, we investigate how interface-induced polarization affects the photovoltaic performance of hybrid perovskite solar cell (PSC) devices. The polarization of the hole transport layer (HTL) is regulated through incorporating metallic-like MoO
x
into PEDOT:PSS. The common MoO3 doped into PEDOT:PSS is used as a reference, and the device that used PEDOT:PSS-MoO
x
as the HTL shows an enhanced J
sc and FF compared to the reference device. The open-circuit photovoltage decay and impedance spectroscopy measurements indicate that trap-assisted recombination is effectively suppressed at the interface between the hybrid perovskite and the PEDOT:PSS-MoO
x
HTL, while severe trap assisted recombination takes place at the perovskite/PEDOT:PSS and perovskite/PEDOT:PSS-MoO3 interface. We attribute these experimental findings to the fact that the incorporation of metallic-like Mo5+ into PEDOT:PSS enhances the conductivity of HTL and the interface polarization between PEDTOT:PSS layer and perovskite, which helps to induce an interface polarization electric field to facilitate separation of charges and screen the recombination between the traps and free charges.
The analysis of air-cooled heat exchanger for Reactor Cavity Cooling System (RCCS) on Experimental Power Reactor (RDE) design
Authors: Susmikanti Mike , Yunus Muhammad , Tjahjono Hendro , Kusumastuti Rahayu , Sulistyo Jos Budi 
Published: May 2020

Abstract
The National Nuclear Energy Agency (BATAN) is designing the Experimental Power Reactor (RDE). The Reactor Cavity Cooling System (RCCS) is a new basic design in the nuclear power plant. It will be incorporated into High-Temperature Reactors (HTR), which is one proposed generation of IV reactors. While HTR has been designed and operated, the RCCS design is unique to the recent generation of gas-cooled reactors as a passive decay heat removal system. However, many aspects of the new air- or water-cooled design still need to be investigated on RCCS. The temperature, mass flow, configuration of the riser, and number of the risers on the water-cooled heat exchanger system which is used is a necessary test. The RCCS designs have not been studied for the RDE design. The heat-transfer and fluid-flow on the RCCS facility have not been investigated for the air-cooled cavity cooling system. The aim of this study is to examine the condition of the air-cooled heat exchanger of RCCS for RDE 10 MWth design. The pressure, temperature, and velocity with certain diameters of cooling pipes are computed with FLUENT 6.3 computational fluid dynamics (CFD) software package under a mass flow rate variation. The pressure, the flow velocity and delta temperature outlet were examined on the RCCS process. The air-cooled heat exchanger in RDE basic design was found to attain safe operation.