bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Lithium-6 as a Diagnostic of the Lithium-enrichment Mechanism in Red Giants
Authors: Aguilera-Gómez Claudia , Chanamé Julio , Pinsonneault Marc H. 
Published: July 2020

Abstract
High lithium-7 (7Li) abundances in giants are indicative of nonstandard physical processes affecting the star. Mechanisms that could produce this signature include contamination from an external source, such as planets, or internal production and subsequent mixing to the stellar surface. However, distinguishing between different families of solutions has proven challenging, and there is no current consensus model that explains all the data. The lithium-6 (6Li) abundance may be a potentially important discriminant, as the relative 6Li and 7Li abundances are expected to be different if the enrichment were to come from internal production or from engulfment. In this work, we model the 6Li and 7Li abundances of different giants after the engulfment of a substellar mass companion. Given that 6Li is more strongly affected by Galactic chemical evolution than 7Li, 6Li is not a good discriminant at low metallicities, where it is expected to be low in both star and planet. For modeled metallicities ([Fe/H] > −0.5), we use a “best-case” initial 6Li/7Li ratio equal to the solar value. 6Li increases significantly after the engulfment of a companion. However, at metallicities close to solar and higher, the 6Li signal does not last long in the stellar surface. As such, detection of surface 6Li in metal-rich red giants would most likely indicate the action of a mechanism for 6Li enrichment other than planet engulfment. At the same time, 6Li should not be used to reject the hypothesis of engulfment in a 7Li-enriched giant or to support a particular 7Li-enhancement mechanism.
Discovery of a [C i]-faint, CO-bright Galaxy: ALMA Observations of the Merging Galaxy NGC 6052
Authors: Michiyama Tomonari , Ueda Junko , Tadaki Ken-ichi , Bolatto Alberto , Molina Juan , Saito Toshiki , Yamashita Takuji , Zhuang Ming-Yang , Nakanishi Kouichiro , Iono Daisuke , Wang Ran , Ho Luis C. 
Published: July 2020

Abstract
We report sensitive [C i] 3
P
1–3
P
0 and 12CO J = 4–3 observations of the nearby merging galaxy NGC 6052 using the Morita (Atacama Compact) Array of the Atacama Large Millimeter/submillimeter Array (ALMA). We detect 12CO J = 4–3 toward the northern part of NGC 6052, but [C i] 3
P
1–3
P
0 is not detected with a [C i] 3
P
1–3
P
0 to 12CO J = 4–3 line luminosity ratio of ≲0.07. According to models of photodissociation regions, the unusual weakness of [C i] 3
P
1–3
P
0 relative to 12CO J = 4–3 can be explained if the interstellar medium has a hydrogen density larger than

, conditions that might arise naturally in the ongoing merging process in NGC 6052. Its [C I] 3
P
1–3
P
0 emission is also weaker than expected given the molecular gas mass inferred from previous measurements of 12CO J = 1–0 and 12CO J = 2–1. This suggests that [C I]3
P
1–3
P
0 may not be a reliable tracer of molecular gas mass in this galaxy. NGC 6052 is a unique laboratory to investigate how the merger process impacts the molecular gas distribution.
Impairment of coronary flow and left ventricular function in patients with slow coronary flow phenomenon and other types of microvascular angina
Authors: Denchev Stefan , Emilova Niya , Gospodinova Mariana , Dimitrov Simeon 
Published: July 2020

Purpose: We aimed at assessing the impairment in coronary flow and left ventricular function in patients without obstructive coronary disease on anti-ischemic treatment admitted with diagnosis unstable angina. Material and methods: The epicardial coronary flow was evaluated in 71 patients with unstable angina in absence of coronary stenosis >50% applying the methods the corrected TIMI frame count and systolic arrest of coronary flow at coronary angiography. The abnormalities in the diastolic function were assessed by echocardiography using PW-Doppler of the diastolic mitral flow and tissue Doppler imaging. Results: The early diastolic velocity of interventricular septum (E’sept) and left ventricular free wall (E’ lat) were reduced in the SFLVH group compared to SCFP and the patients with normal coronary flow. Significant difference was found in between the patients with SFLVH and SCFP regarding DT and A-wave velocity in sub-analysis. The epicardial coronary flow of the patients with SFLVH was as tendency impaired compared to SCFP. The therapy with β- blocker alone or combined with calcium channel blocker or nitrate did not influence either cardiac function or coronary flow in this analysis. Conclusion: Slower left ventricular relaxation is typical for the patients with microvascular angina and left ventricular hypertrophy associated with hypertension on treatment compared to SCFP and patients with normal coronary flow.
Acute myocarditis in a patient with parainfluenza infection, seven years after bone marrow transplantation
Authors: Marinov Nikolay , Simova Iana , Petrov Ivo 
Published: July 2020

Myocarditis is an inflammatory disease of the myocardium, with heterogeneous etiology. Although rare, myocarditis can be a complication of the influenza infection. In the majority of cases, viral myocarditis is a self-limiting infection passing without permanent changes in the myocardium. We present a clinical case of a 30-year-old woman with acute heart failure in the course of respiratory infection accompanied by severe systolic dysfunction (left ventricular (LV) ejection fraction (EF) 16%). The patient was treated according to the current guideline recommendations for the treatment of acute and chronic heart failure with the conjunction of immunomodulating and metabolic therapy. During hospitalization from microbial and viral testing, acute-phase antibodies to parainfluenza virus were identified. Following the treatment, a complete resolution of heart failure symptoms and restoration of LVEF to baseline (40%) was observed. Timely initiation of treatment in myocarditis, followed by good clinical course and regression of LV systolic dysfunction, in some cases may cancel invasive procedures such as endomyocardial biopsy.
Impairments of haemostasis and therapeutic management in patients with COVID-19
Authors: Cherneva Zheina , Cherneva Radostina 
Published: July 2020

The lack of prior immunity to SARS-CoV-2 coronavirus (COVID-19) infection has led to pandemic, where there is no certain management, regarding the complications of this viral illness. The lungs are the target organ for COVID-19 and patients develop acute lung injury that may progress to respiratory and multiorgan failure. Recent data shows the presence of diffuse bilateral pulmonary inflammation in COVID-19 infection. It is associated with a specific pulmonary vasculopathy, defined as pulmonary intravascular coagulopathy (PIC) that is distinct from disseminated intravascular coagulopathy (DIC). The coagulopathy in the early stages of COVID-19 is characterized by initial elevation of D-dimer and fibrin/fibrinogen degradation products, while abnormalities in prothrombin time, partial thromboplastin time and platelet counts are uncommon. That is why screening of D-dimer and fibrinogen levels, are mandatory. COVID-19-associated coagulopathy should be treated, following the guidelines for thromboembolic prophylaxis. Although D-dimer is a marker of mortality, current data does not show routine application of anticoagulants, unless otherwise clinically indicated. Bleeding in COVID-19 is uncommon, even when a laboratory constellation for DIC is present. However, if it occurs, standard guidelines for DIC management should be followed.
“Air rage”: A systematic review of research on disruptive airline passenger behaviour 1985-2020
Authors: McLinton Sarven S. , Drury Doug , Masocha Shepard , Savelsberg Harry , Martin Lucy , Lushington Kurt 
Published: July 2020

Purpose: Disruptive airline passenger behaviour (DAPB), i.e. “air rage”, has an adverse impact on crew and passenger well-being and is costly to manage and prevent. Given recent changes in airport management, aircraft design, air traffic volume and behavioural norms this review summaries research findings 1985-2020.Methodology: A systematic review of the research literature containing qualitative or quantitative data examining DAPB. Findings: Nineteen articles satisfied the criteria for inclusion. Most studies involved surveys of cabin crew members and to a lesser extent pilots, airline representatives, passengers and business customers. Content primarily focussed on the frequency and characteristics of DAPB, whilst consequences for staff and evaluation of training to manage DAPB was less represented. A paucity of current research was noted which is not in keeping with the changes over the last decade in the aviation industry and the increase in DAPB events.Originality: This study presents a summary of current findings on DAPB.Practical Implications: A better understanding of the environmental, social and psychological factors underlying DAPB and the effectiveness of staff training and interventions that promote a safe travel environment are required.Social Implications: The current industry trend toward sustainability and better management of security challenges must extend its focus to DAPB, in order to reverse the recent trend of social irresponsibility in air travellers.
HPK1 Influences Regulatory T Cell Functions
Authors: Sawasdikosol Sansana , Zha Renyuan , Fisher Timothy S , Alzabin Saba , Burakoff Steven J 
Published: July 2020

Abstract
Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of TCR-initiated signal transduction. Both the HPK1−/− mice and the genetically engineered mice with a point mutation that disrupts the catalytic activity of HPK1 possess enhanced antitumor immunity, especially when these mice are treated with anti–PD-L1 immune checkpoint Ab. Because CD4+FOXP3+ regulatory T cells (Tregs) play an important role in suppressing tumor immunity, we investigated whether the loss of HPK1 expression could result in the reduction of Treg functions. We found that the number of HPK1−/− Tregs is elevated relative to the number found in wild-type C57/BL6 mice. However, HPK1−/− Tregs lack the ability to carry out effective inhibition of TCR-induced proliferative responses by effector T cells. Furthermore, HPK1−/− Tregs respond to TCR engagement with an elevated and sustained Erk MAPK and p65/RelA NF-κB phosphorylation in comparison with wild-type Tregs. Also, a multiplex cytokine analysis of HPK1−/− Tregs revealed that they demonstrate an aberrant cytokine expression profile when stimulated by anti-CD3ε and anti-CD28 crosslinking, including the uncharacteristic expression of IL-2 and antitumor proinflammatory cytokines and chemokines such as IFN-γ, CCL3, and CCL4. The aberrant HPK1−/− phenotype observed in these studies suggests that HPK1 may play an important role in maintaining Treg functions with wider implications for HPK1 as a novel immunotherapeutic target.
Innate Priming of Neutrophils Potentiates Systemic Multiorgan Injury
Authors: Zhang Yao , Lin RuiCi , Pradhan Kisha , Geng Shuo , Li Liwu 
Published: July 2020

Abstract
Excessive inflammatory reactions mediated by first-responder cells such as neutrophils contribute to the severity of multiorgan failure associated with systemic injury and infection. Systemic subclinical endotoxemia due to mucosal leakage may aggravate neutrophil activation and tissue injury. However, mechanisms responsible for neutrophil inflammatory polarization are not well understood. In this study, we demonstrate that subclinical low-dose endotoxemia can potently polarize neutrophils into an inflammatory state in vivo and in vitro, as reflected in elevated expression of adhesion molecules such as ICAM-1 and CD29, and reduced expression of suppressor molecule CD244. When subjected to a controlled administration of gut-damaging chemical dextran sulfate sodium, mice conditioned with subclinical dose LPS exhibit significantly elevated infiltration of neutrophils into organs such as liver, colon, and spleen, associated with severe multiorgan damage as measured by biochemical as well as histological assays. Subclinical dose LPS is sufficient to induce potent activation of SRC kinase as well as downstream activation of STAT1/STAT5 in neutrophils, contributing to the inflammatory neutrophil polarization. We also demonstrate that the administration of 4-phenylbutyric acid, an agent known to relieve cell stress and enhance peroxisome function, can reduce the activation of SRC kinase and enhance the expression of suppressor molecule CD244 in neutrophils. We show that i.v. injection of 4-phenylbutyric acid conditioned neutrophils can effectively reduce the severity of multiorgan damage in mice challenged with dextran sulfate sodium. Collectively, our data, to our knowledge, reveal novel inflammatory polarization of neutrophils by subclinical endotoxemia conducive for aggravated multiorgan damage as well as potential therapeutic intervention.
PENGARUH MOTIVASI KERJA TERHADAP KINERJA DOSEN PERGURUAN TINGGI SWASTA LABUHAN BATU
Authors: Sakinah Ubudiyah Siregar  , Sri Milfayetti  , Ibnu Hajar  , Akmaluddin  
Published: July 2020

Effect of Work Motivation on the Performance of Labuhan Batu Private University Lecturers]. This study aims to determine and analyze work motivation directly affect the performance of Labuhan Batu Private University lecturers. Subjects were Labuhan Batu Private University lecturers with a total sample of 125 people, taken by means of a random sampling formula using the Slovin formula, and data were analyzed using path analysis after calculating the correlation of all research variables in the form of a matrix. The research findings obtained work motivation has a direct effect on the positive performance of Labuhan Batu Private University lecturers. Obtained a significant path coefficient between work motivation and lecturer performance, namely: ρ65 = 0.21. Furthermore, based on the calculation of the direct influence of work motivation with lecturer performance of 0.212 = 0.044. Thus, work motivation that directly determines changes in lecturer performance is 4.4%.
Abstrak
Pengaruh Motivasi Kerja Terhadap Kinerja Dosen Perguruan Tinggi Swasta Labuhan Batu]. Penelitian ini bertujuan mengetahui dan menganalisis motivasi kerja berpengaruh langsung terhadap kinerja dosen Perguruan Tinggi Swasta Labuhan Batu. Subjek penelitian adalah dosen Perguruan Tinggi Swasta Labuhan Batu dengan jumlah sampel sebanyak 125 orang, yang diambil dengan cara rumus random sampling menggunakan rumus Slovin, dan data dianalisis dengan menggunakan analisis jalur setelah dihitung korelasi seluruh variabel penelitian dalam bentuk matriks. Hasil temuan penelitian diperoleh Motivasi kerja berpengaruh langsung terhadap positif kinerja dosen Perguruan Tinggi Swasta Labuhan Batu. diperoleh koefisien jalur yang signifikan antara motivasi kerja dengan Kinerja dosen, yaitu: ρ65 = 0,21, Selanjutnya, berdasarkan hasil perhitungan pengaruh langsung motivasi kerja dengan kinerja dosen sebesar 0,212 =0,044. Dengan demikian, motivasi kerja yang secara langsung menentukan perubahan- perubahan kinerja dosen adalah sebesar 4,4 %.
Kata Kunci: motivasi kerja, kinerja dosen
PENGARUH MODEL BLENDED LEARNING ROTASI DAN KECERDASAN INTRAPERSONAL TERHADAP HASIL BELAJAR IPA DI SMP
Authors: Siti Ambarli  , Zulfiati Syahrial  , Mochammad Sukardjo  
Published: July 2020

The background of this research is based on low result of science learning outcomes and usage of Information and Communication Technology (ICT) in learning process that is not optimal yet at PB Soedirman Junior High School Jakarta. The general objective in this research is to know the effect of blended learning rotation model and intrapersonal intelligence on science learning outcomes in junior high school. It was a quantitative research with an experimental method and 2x2 treatment by level design. The results of data analysis and interpretation indicates that; (1) students who were using blended learning rotation model Lab Rotation had higher learning outcomes than those by blended learning rotation model Station Rotation; (2) there was an effect of interaction between blended learning rotation model and intrapersonal intelligence on student learning outcomes in science subject; (3) students with higher intrapersonal intelligence who were using blended learning rotation model Lab Rotation had higher learning outcomes than those by blended learning rotation model Station Rotation; (4) students with lower intrapersonal intelligence who were using blended learning rotation model Lab Rotation had lower learning outcomes than those by blended learning rotation model Station Rotation.
Abstrak
Penelitian ini dilator belakangi oleh masih rendahnya hasil belajar IPA serta pemanfaatan Teknologi Informasi dan Komunikasi (TIK) dalam pembelajaran yang belum optimal di SMP Islam PB Soedirman Jakarta. Tujuan umum yang ingin dicapai dalam penelitian ini adalah untuk mengetahui pengaruh dari penggunaan model blended learning rotasi dan kecerdasan intrapersonal yang dimiliki peserta didik terhadap hasil belajar IPA di SMP. Penelitian ini menggunakan metode eksperimen dengan desain penelitian treatment by level 2x2. Hasil analisis dan interpretasi data menunjukkan bahwa; 1) peserta didik yang menggunakan model blended learning rotasi tipe Lab Rotation memiliki hasil belajar IPA yang lebih tinggi dibandingkan dengan model blended learning rotasi tipe Station Rotation; 2) terdapat pengaruh interaksi antara model blended learning rotasi dan kecerdasan intrapersonal terhadap hasil belajar IPA peserta didik; 3) peserta didik dengan kecerdasan intrapersonal tinggi yang menggunakan model blended learning rotasi tipe Lab Rotation memiliki hasil belajar IPA yang lebih tinggi dibandingkan dengan model blended learning rotasi tipe Station Rotation; 4) peserta didik dengan kecerdasan intrapersonal rendah yang menggunakan model blended learning rotasi tipe Station Rotation memiliki hasil belajar IPA yang lebih tinggi dibandingkan dengan model blended learning rotasi tipe Lab Rotation.
Kata Kunci: blended learning, lab rotation, station rotation, kecerdasan intrapersonal, hasil belajar IPA
Pattern of Prevention-of-Mother-to-Child-Transmission Service by Private Hospitals In Makurdi Nigeria
Authors: Ochejele S , Akuse R M , Akuse J T , Musa J , Odusolu P , Abah R O , Eka P O 
Published: July 2020

Nigeria has the highest number of new HIV infections worldwide and Benue State was reported to have the highest HIV Prevalence in the country. These may partly be due to low coverage of Prevention-of-Mother-to-child-transmission services in private hospitals. Prevention-of-Mother-to-Child-Transmission outlets are concentrated in public facilities but many people patronize private hospitals. This study assessed Prevention-of-Mother-to-Child-Transmission Service provision by private hospitals in Makurdi. A Cross sectional survey of 12 (private-for-profit) registered hospitals with facilities for antenatal and delivery care was carried out. Information was obtained using structured questionnaires. All hospitals performed HIV testing. Six (50%) routinely counseled all pregnant women for testing. Eight (66.7%) offered Prevention-of-Mother-to-Child-Transmission Services. Four (33.3%) had staff trained in Prevention-of-Mother-to-Child-Transmission but one hospital where only midwives were trained did not provide Prevention-of-Mother-to-Child-Transmission Services. Five (41.7%) of the hospitals gave antiretroviral prophylaxis, none had facilities for CD4 count or viral load. A total of 4(50%) of the facilities provided care for infants but only one collected samples for early infant diagnosis. Service delivery appeared to be influenced by cost and staff training. Gaps in service delivery included lack of routine HIV testing, inadequate ARV prophylaxis, inadequate care and support to infants and family members, limited laboratory capacity and use of obstetric procedures which could increase transmission. Private health facilities need support from governments and international partners. Care must be taken to involve medical directors of hospitals in training, provide regular updates about protocols and linkages with other organizations offering services they lack. This would increase service coverage, improve quality of services and source data on Prevention-of-Mother-to-Child-Transmission Services.
Advanced treatment of waste water using microalgae in and around the region of Gengavalli
Authors: Dr. P. Vijaya Kumar  , Dr. S. Ananthakrishnan  
Published: July 2020

The present study illustrates the efficiency of microalgae based treatment system. Treatment of wastewater with microalgae based system have the ability of remove the nutrients( nitrogen , phosphorus and other nutrients ) , heavy metals ,toxic substance (both organic and inorganic) , BOD ,COD and other impurities present in the waste water by using the sunlight, co2 and impurities like nutrients present in the wastewater. The microalgae also have the ability of the fix the excess carbon dioxide present in the environment and release the oxygen and solve the problem of global warming .According to the various study the nutrients removal efficiency of 78- 99% of nitrogen and phosphorus the treatment system also succeed to removal of the 40-65%of COD , BOD and other impurities present in wastewater. The organic and inorganic substance released into the environment as a result of domestic, agricultural and industrial wastewater. The normal primary & secondary treatment process are involved in the treatment. Present investigation focuses on the bioremediation of waste water using microalgae.
A 17-year dataset of surface water fugacity of CO2 along with calculated pH, aragonite saturation state and air–sea CO2 fluxes in the northern Caribbean Sea
Authors: Wanninkhof Rik , Pierrot Denis , Sullivan Kevin , Barbero Leticia , Triñanes Joaquin 
Published: July 2020

Abstract. A high-quality dataset of surface water fugacity
of CO2 (fCO2w)1, consisting of over a
million observations, and derived products are presented for the northern
Caribbean Sea, covering the time span from 2002 through 2018. Prior to
installation of automated pCO2 systems on cruise ships of Royal Caribbean International and subsidiaries, very limited surface water carbon
data were available in this region. With this observational program, the
northern Caribbean Sea has now become one of the best-sampled regions for
pCO2 of the world ocean. The dataset and derived quantities are
binned and averaged on a 1∘ monthly grid and are available at
http://accession.nodc.noaa.gov/0207749 (last access: 30 June 2020)
(https://doi.org/10.25921/2swk-9w56; Wanninkhof et al., 2019a). The derived
quantities include total alkalinity (TA), acidity (pH), aragonite saturation
state (ΩAr) and air–sea CO2 flux and cover the region
from 15 to 28∘ N and 88 to 62∘ W. The gridded data and products are used for determination of status and
trends of ocean acidification, for quantifying air–sea CO2 fluxes and
for ground-truthing models. Methodologies to derive the TA, pH and ΩAr and to calculate the fluxes from fCO2w temperature and
salinity are described.