bluuebunny/crossref_metadata_2025_split huggingface dataset:
KIF4A and STIL act as pan-cancer diagnostic and prognostic biomarkers by bioinformatics analysis and verifcation in osteosarcoma
Authors: Pan Jiankang , Luo Yong , Lei Xiaohua , Mao Xinzhan 
Published: February 2020

Abstract
Background: Cancer is a disease of abnormal cell proliferation that is caused by aberrantly expressed cancer-related genes. Transcriptome analysis to identify differential gene expression between tumors and paring normal tissue can help to reveal the key process of cell proliferation in cancer. Methods: By screening RNA-seq data covering twelve types of cancer and their paring normal tissue from the cancer genome atlas (TCGA), we identified twenty-eight cell-cycle-related genes that were overexpressed in no less than ten types of cancers. Results: Among them, kinesin family member 4A (KIF4A) and stromal tumor infiltrating lymphocyte (STIL) exhibited upregulated expression in eleven types of cancer, making them promising pan-cancer diagnostic markers. The high expression of either KIF4A or STIL indicates poor prognosis in four types of cancer. We further conducted the expression of KIF4A and STIL by immunohistochemistry（IHC） in osteosarcoma（OS） and paring normal tissue samples from a cohort of 57 osteosarcoma patients,which confirmed the results of bioinformatics analysis . Conclusions: KIF4A and STIL can serve as pan-cancer diagnostic and prognostic markers. The fact that they both function in the mitotic chromosome segregation process further emphasizes the importance of mitosis regulation and chromosome stability in carcinogenesis and cancer development.
The role of hidden curriculum in the formation of professional ethics in the Iranian medical students
Authors: safari yahya , khatoni Alireza , Khodamoradi ehsan , Rezaei mansour 
Published: February 2020

Abstract
Background: Professionalism and medical ethics are a vital quality for doctors, which has been taken into account seriously in recent years. Perception of the factors affecting professionalism may help to develop more efficient approaches to promote this quality in medical education. Objective: This study was aimed to explain the role of hidden curriculum in the formation of professional ethics in the Iranian medical students. Methods: This qualitative study was performed on 15 medical interns using grounded theory. Sampling was started by purposive sampling and continued through theoretical sampling until complete data saturation. Data collection and analysis were done simultaneously. Results: The analysis of the participants’ interviews and reduction of findings using common themes yielded one class and four categories as well as a number of concepts as the role of hidden curriculum in the formation of professional ethics in medical students. The categories included the role of modeling in the formation of professional ethics, role of education in formation of professional ethics, role of environmental factors in the formation of professional ethics, and role of personal and inherent attributes in the formation of professional ethics. Conclusion: The curriculum developers and medical education authorities need to proceed in line with the findings of the present study to provide a proper learning environment in which the modeling, learning, and teaching conditions and supportive environmental atmosphere are taken into account in accordance with the inherent and individual characteristics of the learners in order to guarantee the formation of professional ethics in the medical students.
Intelligent agent for formal modelling of temporal multi-agent systems
Authors: Qasim Awais , Aziz Zeeshan , Kazmi Syed Asad Raza , Khalid Adnan , Fakhir Ilyas , Hassan Jawad 
Published: February 2020

Abstract
Software systems are becoming complex and dynamic with the passage of time, and to provide better fault tolerance and resource management they need to have the ability of self-adaptation. Multi-agent systems paradigm is an active area of research for modeling real-time systems. In this research, we have proposed a new agent named SA-ARTIS-agent, which is designed to work in hard real-time temporal constraints with the ability of self-adaptation. This agent can be used for the formal modeling of any self-adaptive real-time multi-agent system. Our agent integrates the MAPE-K feedback loop with ARTIS agent for the provision of self-adaptation. For an unambiguous description, we formally specify our SA-ARTIS-agent using Time-Communicating Object-Z (TCOZ) language. The objective of this research is to provide an intelligent agent with self-adaptive abilities for the execution of tasks with temporal constraints. Previous works in this domain have used Z language which is not expressive to model the distributed communication process of agents. The novelty of our work is that we specified the non-terminating behavior of agents using active class concept of TCOZ and expressed the distributed communication among agents. For communication between active entities, channel communication mechanism of TCOZ is utilized. We demonstrate the effectiveness of the proposed agent using a real-time case study of traffic monitoring system.
Febrile illness after a beach day: a case of salmonella bacteremia from oral exposure to a sand dollar
Authors: Trigo Carlos E. , Patel Faisalmohemed 
Published: February 2020

Abstract
This case report discusses a rare presentation of salmonella bacteremia after an oral exposure to a sand dollar in a pediatric patient. A 2-year-old Hispanic male presented to the emergency department with a chief complaint of diarrhea and fever for 8 days after a family trip to Destin beach, Florida, during the sea turtle nesting season. The symptoms began a day after the patient took a bite on a sand dollar found on the beach that caused a small wound inside his cheek. The laboratory testing done in the emergency department was remarkable for blood and stool culture testing positive for non-typhoid salmonella. The sand dollar is a type of a sea urchin commonly found on sandy beaches and consists of an anatomical filtration system to consume sandy water. It could be inferred that the increased presence of sea turtles during the time of the patient's visit to Destin beach could have led to higher levels of salmonella in the seawater and consequently in the sand dollar, possibly leading to the inoculation of salmonella in this patient. To the best of our knowledge, this is a first case report that links oral exposure of the sand dollar to invasive salmonellosis.
Enhanced removal of refractory pollutant from aniline aerofloat wastewater using combined vacuum ultraviolet and ozone (VUV/O3) process
Authors: Deng Xiaoyu , Zhang Dachao , Wu Meng , Antwi Philip , Su Hao , Lai Cheng 
Published: February 2020

Abstract
Aerofloats, such as aniline aerofloat ((C6H5NH)2PSSH), are extensively employed for collection activities in wastewater particularly in cases where minerals are in flotation. Although this aniline aerofloat has efficient collection properties, they are ordinarily biologically persistent chemicals in which case their residual, as well as their byproducts, pose great environmental risks to water and soils. In this study, the removal efficiency of aniline aerofloat (AAF) by a combined vacuum ultraviolet (VUV) and ozone (O3) process (VUV/O3) was evaluated. Furthermore, the impacts of pH, O3, the concentration of AAF and coexisting ions (SiO32−, CO32−, Cl− (Na+), SO42−, Ca2+) were systematically studied. The experiments revealed that, with an initial AAF of 15 mg/L, AAF removal &gt;88% was feasible with a reaction time of 60 min, pH of 8 and O3 of 6 g/h. The order of influence of the selected coexisting ions on the degradation of AAF by VUV/O3 was Ca2+ &gt; CO32− &gt; SiO32− &gt; Cl− (Na+) &gt;SO42−. Compared with VUV and O3 in terms of pollutant degradation rate, VUV/O3 showed a remarkable performance, followed by O3 and VUV. Additionally, the degradation kinetics of AAF by the VUV/O3 process agreed well with first-order elimination kinetics.
Treatment of fish processing industry wastewater using hydrodynamic cavitational reactor with biodegradability improvement
Authors: Dhanke Prashant , Wagh Sameer , Patil Abhijeet 
Published: February 2020

Abstract
Water generated from the fish processing industry is contaminated with organic matter. This organic matter present in wastewater increases the biochemical oxygen demand (BOD) and chemical oxygen demand (COD). A new technology, hydrodynamic cavitation (HC) is used to deal with this wastewater produced in fish processing plants. The orifice plate is used in the HC reactor to generate a cavitation effect. The intensification of this technique was carried out with the help of hydrogen peroxide (H2O2) and TiO2. The treatment of this wastewater is reported in terms of percent degradation in BOD and COD and in biodegradability index (BI). Operating parameters like inlet pressure, pH, operating temperature and H2O2 doses were used to find the optimum condition. 15 g/L of H2O2 gave 69.5% reduction of COD in the 120 min of treatment that also increases BI value to 0.93 at inlet pressure 8 bar, Plate-5, temperature (30 °C), and pH 4. In the ultrasonic cavitation (UC) reactor, COD reduction is 68.7% without TiO2 and with TiO2 it is 71.2%. Also, this HC and UC reactor reduced CFU count to a great extent at the same operating conditions.
“Avanço da Maré”, Riscos Ambientais e Estado
Authors: Mayara Silva Nascimento  , De Oliveira Wilson José Ferreira de , Moises Cruz Souza  
Published: February 2020

Este artigo analisa a formação do problema público que conduziu àpolítica denominada defesa litorânea do bairro 13 de julho, em Aracaju/SE. Especificamente, narra a gênese da construção dos argumentosque sustentaram a retórica do risco iminente, como também as sucessivasetapas de seu desenvolvimento na agenda pública. Foi realizadaa codificação e análise de 83 artigos obtidos em alguns dos principaissites de notícias do estado de Sergipe por meio do software Nvivo 10.Os resultados obtidos permitiram constatar que a utilização de vínculose recursos jurídicos se tornou central na dinâmica de execuçãode tal política, devido ao grau de conflito entre os principais gruposenvolvidos. Conclui-se que para melhor dar conta do papel e lugar dajudicialização nos processos de execução das políticas públicas é precisoconsiderar de forma relacional o grau de oposição ou aliança entreos grupos envolvidos na formulação das políticas públicas, suas formasde controle das instâncias estatais e seus vínculos com os atores judiciais.
Palavras-chave: Políticas Públicas. Estado. Problema Público. Avançoda Maré.
Wolność synów Bożych na podstawie Rz 8, 12–17 i Ga 4, 1–7
Authors: Górska Hanna 
Published: February 2020

Artykuł przedstawia powiązanie między stanem przybranego synostwa Bożego chrześcijan a wolnością człowieka na podstawie fragmentów Rz 8, 12–17 i Ga 4, 1–7. Na początku przedstawiony zostaje stan człowieka, zanim jeszcze zostanie obdarowany nową egzystencją, którą jest bycie Bożym dzieckiem. Omówione zostają rodzaje niewoli, które w tych dwóch fragmentach przedstawia św. Paweł oraz symbolika małoletniego dziedzica. W następnej części artykułu przedstawione zostaje greckie słownictwo, którego używa św. Paweł do opisania stanu nowej egzystencji chrześcijan, a mianowicie: ἡ υἱοθεσίά τό τέκνον, ὁ υἱός. Ostatnia część pracy poświęcona jest natomiast powiązaniu, które istnieje między przybranym synostwem Bożym oraz wolnością.
Surgeons’ Interactions With and Attitudes Toward E-Patients: Questionnaire Study in Germany and Oman
Authors: Masters Ken , Loda Teresa , Johannink Jonas , Al-Abri Rashid , Herrmann-Werner Anne 
Published: February 2020

Background
Doctors’ interactions with and attitudes toward e-patients have an overall impact on health care delivery.

Objective
This study aimed to gauge surgeons’ interactions with e-patients, their attitudes toward those e-patient activities, the possible impact on the delivery of health care, and the reasons behind those activities and attitudes.

Methods
We created a paper-based and electronic survey form based on pertinent variables identified in the literature, and from March 2018 to July 2018 we surveyed 49 surgeons in Germany and 59 surgeons in Oman, asking them about their interactions with and attitudes toward e-patients. Data were stored in Microsoft Excel and SPSS, and descriptive statistics, Pearson correlations, and chi-square tests were performed on the data.

Results
Of our sample, 71% (35/49) of the German surgeons and 56% (33/59) of the Omani surgeons communicated electronically with their patients. Although the German surgeons spent a greater percentage of Internet usage time on work-related activities (χ218=32.5; P=.02) than the Omani surgeons, there were many similarities in their activities. An outstanding difference was that the German surgeons used email with their patients more than the Omani surgeons (χ21=9.0; P=.003), and the Omani surgeons used social media, specifically WhatsApp, more than the German surgeons (χ21=18.6; P<.001). Overall, the surgeons were equally positive about the most common e-patient activities such as bringing material from the internet to the consultation (mean 4.11, SD 1.6), although the German surgeons (mean 3.43, SD 1.9) were more concerned (P=.001) than the Omani surgeons (mean 2.32, SD 1.3) about the potential loss of control and time consumption (German: mean 5.10, SD 1.4 and Omani: mean 3.92, SD 1.6; P<.001).

Conclusions
The interactions show a high degree of engagement with e-patients. The differences between the German and the Omani surgeons in the preferred methods of communication are possibly closely linked to cultural differences and recent historical events. These differences may, moreover, indicate e-patients’ desired method of electronic communication to include social media. The low impact of surgeons’ attitudes on the activities may also result from a normalization of many e-patient activities, irrespective of the doctors’ attitudes and influences.
Ollas del emprendimiento: aproximación natural sobre la cocción del negocio
Authors: Piñero Lorena , Perozo Lorheny , Sierra Lenin , Carrillo Ilfredd 
Published: February 2020

El propósito del estudio consistió en describir las ollas del emprendimiento a partir de la aproximación natural que sobre la cocción del negocio tienen los venezolanos movilizados al estado fronterizo, mediante la identificación y comparación de los factores de percepción que condicionan el deseo de emprendimiento que los inspira. El mismo se desarrolló a través de una metodología afianzada en el método cuantitativo, de carácter descriptivo, con diseño de campo no experimental, transeccional. La técnica de recolección de información fue la observación directa, la cual dio origen al diseño de una entrevista, conformada por 18 preguntas cerradas con alternativas frecuentemente (5), a menudo (4), rara vez (3), pocas veces (2) y nunca (1), validada en su contenido por 5 expertos, y aplicada en dos momentos a una muestra de 123 ciudadanos que salieron e ingresaron a Venezuela por la vía fronteriza, La Raya-Maicao. La interpretación y análisis de los datos se realizó en términos de valores porcentuales para medir el comportamiento de la dimensión factores de percepción (1er grupo y 2do grupo). Entre las conclusiones se demostró que los dos grupos entrevistados salieron llenos de seguridad y con interés de asumir riesgos de carácter social y económico. El grupo que regresó trajo una olla repleta de pocas motivaciones producto de las mínimas condiciones encontradas en la nación colombiana para su formación como emprendedores.
Los Negocios de Coworking y la Seguridad y Salud del Trabajo (Caso Perú)
Authors: Armas Carlos , Armas Morales Hugo Alberto 
Published: February 2020

Explora el negocio denominado coworking o trabajo cooperativo en cuanto a la seguridad y salud del trabajador en los espacios laborales de alquiler de oficinas, ya sea trate del trabajador coworking autónomo o dependiente de una empresa, así como el trabajador mismo del coworking de conformidad con la Ley de Seguridad y Salud en el Trabajo (ley No 29783). Ello involucra evaluar el alcance de dicha normativa, así como también las estipulaciones contractuales del coworking con sus usuarios. Asimismo se deslinda las obligaciones y responsabilidades que corresponda reguardar en función de la normativa peruana.
GUI Design for Comparative Output Signal DFT and DTFT with LabVIEW
Authors: Astharini Dwi , Aulia Tsaura , Wulandari Putri , Alamtaha Rahmat , Afisha Rifqy 
Published: February 2020

An application GUI (Graphical User Interface) is designed as a software simulation to compare the output signal of DFT and DTFT. DFT (Discrete Fourier Transform) and DTFT (Discrete Time Fourier Transform) are part of the digital signal processing. Digital signal processing is an analog signal processing method uses a mathematical technique to perform a transformation or retrieving information in digital form. One of the benefits of digital signal processing is to facilitate the representation of the signal, because the signal in digital form will be more visible, easily processed and has high accuracy. This GUI application designed using LabVIEW from National Instruments. LabVIEW is a software graphical programming or a block diagram. LabVIEW program known as VI or Virtual Instrument. The input signal in this application is a square signal
The determinants of economic resilience in rural regions. An examination of the Portuguese case
Authors: Hennebry Barraí 
Published: February 2020

Abstract
This paper examines the factors that contributed to the economic resilience of rural regions in Portugal following the recent crisis. Portugal has for a long time faced the issue of regionalisation. However, rural regions in Portugal are not homogenous. Rural regions in Portugal are very diverse and experience very different economic realities. This paper adds to the growing body of literature on regional resilience by focusing exclusively on rural regions. Using an adaptation of Martin’s (2012) sensitivity index as a measure of resilience and bivariate analysis this paper examines the determinants of resilience in rural regions. In terms of economic structure, the paper interestingly finds that reliance on agriculture was beneficial while innovativeness hindered resilience. As for measures of social capital, the paper presents some contradictory findings. Higher rates of crime had a negative impact on resilience, however higher political participation also had a negative impact.
ASPEK YURIDIS PERJANJIAN BUSINESS FRANCHISE DI INDONESIA
Authors: Triyana Lily 
Published: February 2020

In Indonesia there is no regulation about franchise. Same thing is also experienced of many state, for example English and Australian. No special regulation about franchising can be consedered to be good news or is bad news. The bad news is wth no special guidance, hence goodnesss of franchisor amd also of franchisee have to reckon on written agreement in cooperation contract. Irts meaning both parties have to neglectless and meticulous to the what agreed on. Protection of other decision which arrange an cooperation of Franchising represent the source of which whereas can be made by guidance do complied agreement have the basis for real correct and fair. Association of franhcising generally realese code of ethic of franchising.good news of inexistence regulation of area of franchising is goodness of franchisor and fracnhisee earn free compromise whateverly. As hold of legal fundament of agreement of franchise in Indonesia is freedom contract such as those which arranged in section 1338 KUH Perdata and by concidering conditions of section 1338 KUHP Perdata. Law contract in Indonesia embrace open system meaning that each and everyone is free to make all kinds of contract. In section 1338 KUH Perdata contained by the following rule all made contract lawfully will bind over them making it own. In the case conditions of 1320 section of KUH this Perdata is fulfilled by hence comand of section 1338 KUH Perdata. The making agreement act as code/law to all party. So franchise, and vitally hence to all party arrange agreement content detail.Solving of dispute represent problem which in many is important to licencer, specially In the case of giving of license. Right of intellectual properties in the form of trade secret. Solving of dispute which is through jurisdiction forum, it is though enabled to be emphasized in conference closed (for the secret of trade) felt concerned abaout by licencer party will become an openly forum to receiver of license which do not good mine. To avoid the mentioned hence better each ; every dispute realted to agreement of giving license finished in framework of alternative of is solving of dispute, including in it arbitrase.Ordinary license agreement unlike giving of agreement of license of franchise. If at giving of agreement of license usually only covering giving of permission cover all sort of kinds of intellectual property that appliances bought or rented from him. Besides so-called above, agreement of franchise are; giving of license abaout name of trading, model brand, desain, ets. Rules that can be grouped in the field of contractual law and in the field of law about intellectual property.
KAJIAN TERHADAP PERDA BERMASALAH DARI SUDUT PANDANG HAM
Authors: Saripudin H. 
Published: February 2020

ABSTRAK
Perda yang baik bukanlah Perda yang eksklusif, sehingga kelak menjadi Perda yang bermasalah. Perda yang baik yang sesuai dengan indikator dari segi hukum Legislative Drafting yaitu dari perspektif hukum, sosio-politik, ekonomi dan hak asasi manusia (HAM) agar tidak bertentangan dengan prinsip Negara Kesatuan Republik Indonesia.
Integrated Geophysical & Geological Modeling to Conquer World-Class E&P Difficulties on Qinghai-Tibet Plateau
Authors: Dong Yongcang , Tan Chenqing , Wang Haifeng , Tong Yanming , Wang Yongsheng , Wu Chuan , Guan Bin 
Published: February 2020

The Qaidam Basin is located in the northeastern part of the Qinghai-Tibet Plateau (or Tibetan Plateau). It is the world's highest altitude petroliferous basin (the altitude is usually more than 3000m above sea level). But this basin is more famous for its ‘double complex’ in terms of surface and subsurface structures.
Our study areas, YingXi and YingZhong are located at the southwest of YingXiongling structural belt within the Qaidam basin. From the , we can see the "double complex" structures very clearly. The surface is full of wind erosion mountains . The serious elevation variation proposes huge challenge for seismic data acquisition, statics correction and near surface modeling. Meanwhile the subsurface is thrusted severely . The shallow part is thrusted with detachment faults and mainly comprised of severely deformed fold and Shizgou fault, which is the main fault of the survey. The horizon offset across it is usually quite large up to 2km. The study zone is more than 4000m deep where it is thrusted into imbricate fans with very strong overlying structural disturbing. The structure is cut by several groups of low angle faults. This kind of geological condition may produce quite good traps for oil and gas. Besides the overlying salt layers of the study zone extend to certain range which can be very good seal to prevent the oil and gas from migrating upward along Shizgou fault.
These extremely complex geological situations cause a series of world-class E&P difficulties, such as how to obtain better seismic image, where to drill exploration wells, how to design and drill horizontal development wells with higher success rate, and how to submit OOIP or Reserve to the country for so complex region, etc. But to solve these difficulties, one thing is the key, i.e. the accurate structural delineation. This also the final goal of our work. In this paper we will discuss and show how we reach it by integrated Geophysical & Geological modeling.