bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining Studio Ghibli’s Animated Films: A Study of Students’ Viewing Paths and Creative Projects
Authors: Williams Wendy R. 
Published: January 2020

AbstractBeing literate in today’s world involves more than reading and writing traditional works in print. Students need experiences with a range of multimodal narratives, including animation. Multimodal narratives offer many entry points for engagement, and design plays an important role as readers/viewers navigate their way through these works and make meaning. This qualitative study took place in the U.S. Southwest and involved 20 university students enrolled in a Studio Ghibli Films course. Analysis of coursework using grounded theory and open coding revealed that participants designed nine viewing paths to interpret the films, approaching animated works as narratives, multimodal compositions, cultural/historical artifacts, transformed source materials, products of a director, objects of value, conversations between texts, commentaries, and personal experiences. Participants also composed a wide variety of creative projects that drew on their out‐of‐school interests. Animated works, such as the films of Studio Ghibli, have great potential in education.
Retracted: Long noncoding RNA RHPN1‐AS1, induced by KDM5B, is involved in breast cancer via sponging miR‐6884‐5p
Authors: Liang Dong , Liu Hui , Yang Qinheng , He Yaning , Yan Yuan , Li Na , You Wei 
Published: January 2020

AbstractThe above article, published online in Journal of Cellular Biochemistry on 31 January 2020 in Wiley Online Library (https://doi.org/10.1002/jcb.29645), has been retracted by agreement between the authors, the journal's Editor in Chief, Prof. Dr. Christian Behl, and Wiley Periodicals LLC.The authors asked to retract their article after substantial mistakes in experimental data were found, thus the results are considered to be invalid.
Muscle regeneration in adiponectin knockout mice showed early activation of anti‐inflammatory response with perturbations in myogenesis
Authors: Mosele Francielle C. , Bissi Ricci Rafael , Abreu Phablo , Rosa Neto José C. 
Published: January 2020

AbstractActivation, proliferation, and differentiation of satellite cells can be influenced by extracellular factors, such as adiponectin. This adipokine has been proposed as a regulator of in vitro myogenesis, but its action on in vivo regeneration is not still elucidated. We used C57BL/6 (wild‐type [WT]) and adiponectin knockout (AdKO) mice injured with barium chloride at periods of 3, 7, and 14 days after injury. The AdKO presented a higher number of centralized nuclei after 7 days, and a reduction in myogenic genes was observed after 3 days. Moreover, these mice presented an increase in anti‐inflammatory cytokines after 3 and 7 days, and an increase in the M2 gene marker and proinflammatory cytokines after 7 days. The WT demonstrated an increase in adiponectin messenger RNA after 7 days. These results demonstrate that adiponectin is important in tissue remodeling during regeneration and that its deficiency does not compromise the maturation of muscle fibers, due to an increase in anti‐inflammatory response; however, there is a possible impairment in proinflammatory response and an increase in centralized myonuclei.
Recurrent breast amyloidosis associated with Sjögren's syndrome: A case report with description of the radiologic‐pathologic correlation
Authors: Lee Geon Yang , Ryu Jung Kyu , Lim Sung‐Jig 
Published: January 2020

AbstractWe describe the case of a 41‐year‐old woman with primary Sjögren's syndrome (SS) who presented multiple recurrences of breast amyloidosis. Each recurrence of breast amyloidosis showed different sonographic features, potentially mimicking malignancy. We briefly discuss the possible cause of this variability in imaging features based on the radiologic‐histologic correlation.
Incidence, treatment and outcome of abdominal metastases in extremity soft tissue sarcoma: Results from a multi‐centre study
Authors: Smolle Maria A. , Schaffler Angelika , Leithner Andreas , Van Praag Veroniek M. , Bergovec Marko , Szkandera Joanna , Liegl‐Atzwanger Bernadette , Niethard Maya , Tunn Per‐Ulf , Van De Sande Michiel , Andreou Dimosthenis 
Published: January 2020

AbstractBackground and ObjectivesAbdominal metastases (AM) from soft tissue sarcoma (STS) are rare and prognosis is poor. The aims of the study were to (a) identify risk factors for the development of AM and to (b) investigate the outcome of AM‐patients.MethodsSeven‐hundred‐sixty‐nine STS‐patients with localised disease at diagnosis treated at three tumour centres (2000‐2016) were retrospectively included (409 males; mean age, 55.6 years [range, 8‐96 years]; median follow‐up, 4.1 years [interquartile‐range, 2.5‐6.6 years]).ResultsTwo‐hundred‐two patients (26.3%) developed secondary metastases, and 24 of them AM (3.1%). Ten patients developed first AM (FAM) after a mean of 2.4 years and 14 patients late AM (LAM, after being diagnosed with metastases to other sites) after a mean of 2.0 years. Patients with liposarcoma had a significantly higher risk of developing AM (P = .007), irrespective of grading. There was no difference in post‐metastasis‐survival (PMS) between patients with AM at any time point and those with metastases to other sites (P = .585). Patients with LAM or FAM showed no difference in post‐abdominal‐metastasis‐survival (P = .884).ConclusionsSurvival in patients with AM is poor, irrespective of whether they develop secondarily to other metastases or not. Patients at high‐risk of AM (ie, liposarcoma) may be followed‐up regularly by abdominal‐ultrasound/CT.
Multivisceral resection vs standard gastrectomy for gastric adenocarcinoma
Authors: Dias Andre R. , Pereira Marina A. , Oliveira Rodrigo J. , Ramos Marcus F. K. P. , Szor Daniel J. , Ribeiro Ulysses , Zilberstein Bruno , Cecconello Ivan 
Published: January 2020

AbstractIntroductionMultivisceral resection (MVR) is potentially curative for selected gastric cancer patients, supposedly at the cost of increased complications. However, current data comparing MVR to standard gastrectomy (SG) is lacking.ObjectivesCompare complications and survival after MVR and SG.MethodsIn a retrospective cohort of 1015 patients with gastric adenocarcinoma, 58 underwent MVR and 466 SG. Groups were compared concerning their characteristics, complications, and survival.ResultsOne hundred seventy‐six patients had postoperative complications. Major complications were more frequent after MVR (P = .002). Surgical mortality was 8.6% and 4.9% for MVR and SG (P = .221). Older age, higher morbidities, and MVR were independent risk factors for major complications. The odds ratio for major complications was 5.89 for MVR with one or two organs and 38.01 for MVR with three or more organs. The pancreas was the most commonly removed organ and pT4b disease were confirmed in 34 (58.6%) of the MVR cases. Disease‐free survival (DFS) was lower in MVR patients (51% vs 77.8%; P < .001), being worse according to the number of organs resected. In pN+ patients, DFS was worse after MVR. DFS was equivalent to pT4b and non‐pT4b in the MVR group.ConclusionsIncreased morbidity and lower survival are expected for gastric cancer patients undergoing MVR.
Recyclable and Dual Cross‐Linked High‐Performance Polymer with an Amplified Strength–Toughness Combination
Authors: Du Mengqi , Yang Li , Liao Cong , Diangha Tasah Philas , Ma Yuanchi , Zhang Lin , Lan Yang , Chang Guanjun 
Published: January 2020

AbstractSupramolecular chemistry has provided versatile and affordable solutions for the design of tough, flexible polymers. However, application of supramolecular chemistry has been limited to the production of rigid, high‐performance polymers due to weak segment mobility. This paper describes a new method of toughening rigid high‐performance polymers using the synergistic effect between dual Cu2+‐coordination bonds as a crosslink. These dual Cu2+‐coordination cross‐linked high‐performance polymers are a class of rigid polymers with an outstanding combination of strength and toughness. The distinct lifetimes and binding strengths of the dual Cu2+‐coordination bonds in a rigid polymer network elicit different dynamic behaviors to improve its energy dissipation and mechanical properties. Moreover, the reformation and removal of Cu2+‐coordination bonds by pyrophosphoric acid endows these cross‐linked high‐performance polymers with recyclability.
A fast Fourier transform based direct solver for the Helmholtz problem
Authors: Toivanen Jari , Wolfmayr* Monika 
Published: January 2020

SummaryThis article is devoted to the efficient numerical solution of the Helmholtz equation in a two‐ or three‐dimensional (2D or 3D) rectangular domain with an absorbing boundary condition (ABC). The Helmholtz problem is discretized by standard bilinear and trilinear finite elements on an orthogonal mesh yielding a separable system of linear equations. The main key to high performance is to employ the fast Fourier transform (FFT) within a fast direct solver to solve the large separable systems. The computational complexity of the proposed FFT‐based direct solver is operations. Numerical results for both 2D and 3D problems are presented confirming the efficiency of the method discussed.
A framework for robust quadratic optimal control with parametric dynamic model uncertainty using polynomial chaos
Authors: Lefebvre Tom , De Belie Frederik , Crevecoeur Guillaume 
Published: January 2020

AbstractWe propose a framework tailored to robust optimal control (OC) problems subject to parametric model uncertainty of system dynamics. First, we identify a generic class of robust objective kernels that are based on the class of deterministic quadratic objectives. It is demonstrated how such kernels can be expressed as a function of the stochastic moments of the state and how the objective terms relate to the robustness and performance of the optimal solution. Second, we engage the generalized polynomial chaos (gPC) framework to propagate uncertainty along the state trajectory. Integrating both frameworks makes way to reformulate the problem as a deterministic OC problem in function of the gPC expansion coefficients that can be solved using existing methods. We apply the framework to solve the problem of robust optimal startup behavior of a nonlinear mechanical drivetrain that is subject to a bifurcation in its dynamics.
Burden and quality of life in caregivers of patients with amputated diabetic foot
Authors: Costa Suely , Leite Ângela , Pinheiro Mariana , Pedras Susana , Pereira M. Graça 
Published: January 2020

AbstractInformal caregivers of chronically ill patients often report burden and poor quality of life. This study aimed to evaluate the impact of caring on caregivers of amputated patients with type 2 diabetes and diabetic foot. A cross‐sectional study included a convenience sample of 110 caregivers who answered: the Burden Assessment Scale, the Depression Anxiety Stress Scales, the Social Support Satisfaction Scale, the Family Assessment Device, and the Short Form Health Survey. Multiple linear hierarchical regressions were performed to identify the variables that contributed to the burden and the physical and mental quality of life. Differences in burden as well as physical and mental quality of life were found, according to several caregivers’ sociodemographic characteristics. Lower social support, more distress, and caregiver's perception of the impact of caring on the family dynamics contributed to burden. Lower distress and not having a chronic illness besides diabetes explained the physical quality of life whereas exercise and lower distress explained mental quality of life. To promote quality of life in caregivers and reduce the burden associated with caregiving, interventions should focus on social support, distress, and the practice of exercise.
Expanded carrier screening for preconception reproductive risk assessment: Prevalence of carrier status in a Mexican population
Authors: Hernandez‐Nieto Carlos , Alkon‐Meadows Tamar , Lee Joseph , Cacchione Teresa , Iyune‐Cojab Esther , Garza‐Galvan Maria , Luna‐Rojas Martha , Copperman Alan B , Sandler Benjamin 
Published: January 2020

AbstractObjectiveGenetic carrier screening has the potential to identify couples at risk of having a child affected with an autosomal recessive or X‐linked disorder. However, the current prevalence of carrier status for these conditions in developing countries is not well defined. This study assesses the prevalence of carrier status of selected genetic conditions utilizing an expanded, pan‐ethnic genetic carrier screening panel (ECS) in a large population of Mexican patients.MethodsRetrospective chart review of all patients tested with a single ECS panel at an international infertility center from 2012 to 2018 were included, and the prevalence of positive carrier status in a Mexican population was evaluated.ResultsEight hundred five individuals were analyzed with ECS testing for 283 genetic conditions. Three hundred fifty‐two carriers (43.7%) were identified with 503 pathogenic variants in 145 different genes. Seventeen of the 391 participating couples (4.34%) were identified as being at‐risk couples. The most prevalent alleles found were associated with alpha thalassemia, cystic fibrosis, GJB2 nonsyndromic hearing loss, biotinidase deficiency, and familial Mediterranean fever.ConclusionBased on the prevalence and severity of Mendelian disorders, we recommend that couples who wish to conceive regardless of their ethnicity background explore carrier screening and genetic counseling prior to reproductive medical treatment.
Insulin Glargine in Critically ill Patients: Once/Day versus Twice/Day Dosing
Authors: Fox Marlena A. , Perry Melanie C. , Liu‐DeRyke Xi 
Published: January 2020

ObjectiveTwice/day dosing of insulin glargine has been used to treat hyperglycemia in clinical practice; however, data supporting its use in the critically ill population are lacking. This study was designed to evaluate the safety and efficacy of twice/day insulin glargine in critically ill patients.MethodsA retrospective study was conducted in adult patients admitted to the intensive care units between February 2013 and June 2017 who received insulin glargine twice/day or 40 units or more once/day for 48 hours or longer. Post cardiovascular surgery patients were excluded. Data were collected for up to 14 patient‐days. The efficacy outcomes included the incidence of hyperglycemia (blood glucose [BG] above 180 mg/dl), predose hyperglycemia rate (BG above 180 mg/dl within 4 hrs before the dose), and BG variability (standard deviation). The safety outcome was assessed by the development of hypoglycemia (BG below 70 mg/dl).ResultsA total of 58 patients (twice/day = 23; once/day = 35) were included in the analysis. Demographics were similar between the groups including history of diabetes mellitus, baseline hemoglobin A1C, and home insulin use. No difference was observed between the twice/day and once/day groups in the mean BG (153 vs 154 mg/dl, p=0.95, respectively), and BG variability (46 vs 44 mg/dl, p=0.29, respectively). Although the overall incidence of hyperglycemia was similar between twice/day and once/day groups (96% vs 97%, p=1.00, respectively), the twice/day group had a significantly lower predose hyperglycemia rate (twice/day 0.27 vs once/day 0.43, p=0.02). Additionally, the twice/day group did not experience an increased incidence of hypoglycemia (twice/day 23% vs once/day 34%, p=0.57) or hypoglycemia without having anything by mouth (twice/day 0% vs once/day 9%, p=0.27).ConclusionsThis is the first study demonstrating that twice/day insulin glargine reduced the rate of predose hyperglycemia without increasing the risk of hypoglycemia in critically ill patients. A large randomized study is needed to confirm the safety and efficacy of twice/day glargine in the critically ill.
Acaricidal effects of methyl benzoate against Tetranychus urticae Koch (Acari: Tetranychidae) on common crop plants
Authors: Mostafiz Md Munir , Shim Jae‐Kyoung , Hwang Hwal‐Su , Bunch Heeyoun , Lee Kyeong‐Yeoll 
Published: January 2020

AbstractBACKGROUNDMethyl benzoate (MB) is a small, hydrophobic organic compound isolated from the freshwater fern Salvinia molesta (Salviniales: Salviniaceae). It is used as a fragrance and flavor enhancer owing to its pleasant smell. It has also demonstrated potential as a green pesticide for various groups of insects. However, its effects on mites are yet to be studied.RESULTSHere, we assessed the acaricidal and repellent effects of MB against the two‐spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), under laboratory and greenhouse conditions. MB demonstrated concentration‐dependent contact toxicity against eggs and adults of the mite. A leaf‐dipping assay using 1% MB prevented the hatching of 92.7% of eggs and killed 100% of adults within 48 h of treatment. Concentration–mortality statistics were subjected to probit analysis, and the median lethal concentration (LC50) values for eggs and adults were 0.25% and 0.5%, respectively. Treatment with 1% MB showed the highest mortality (100%), with a median lethal time (LT50) estimated of 8.1 h. The efficacy of MB against adults of T. urticae on tomato plants under greenhouse conditions was 97.5% within 96 h post‐treatment. Further, MB showed significant repellent activity against adult females of T. urticae, although this declined with time. Spraying with 1% MB (three times per plant) was not phytotoxic to bean, cucumber, pepper, or tomato plants.CONCLUSIONMB is highly acaricidal and repellent, but not phytotoxic, and is a promising green pesticide.
Do one‐step mechanisms always involve simultaneous evolution of electron density? QTAIM/IQA analysis of the Curtius rearrangement
Authors: López‐Fernández José L. , Mosquera Ricardo A. , Graña Ana M. 
Published: January 2020

AbstractThe Curtius rearrangement reaction is studied by using quantum theory of atoms in molecules (QTAIM) analysis of the electron density and the interacting quantum atoms (IQA) formalism. Although the rearrangements take place in one stage, two phases are distinguished when the rearranged atom is H: the first one corresponds to the separation of N2, and the second one to the N‐H/C‐H bond rearrangement. The transition state (TS) for the reaction does not represent an intermediate between reagent and product for the migration but for the isolation of the N2molecule. When the migration is undergone by a fluorine atom, no electronic phases can be distinguished and the process is really concerted. As the migration happens closer to the TS, the TS is more similar to the product. The IQA analysis reveals different electron density evolutions for H and F migrations, and the scarce relevance (in terms of energy) of the point where BCPs appear or disappear.
Revisiting the investment anomaly: Financing constraints or limits‐to‐arbitrage?
Authors: Koh Kyungyeon (Rachel) 
Published: January 2020

AbstractThe investment anomaly refers to the pervasive negative predictability in future stock returns following large firm investments. I re‐investigate two competing hypotheses for the potential source of the anomaly: (a) prolonged mispricing due to limits to arbitrage and (b) financing constraints in the context of Q‐theory of investments. The analyses employ new proxies for financing constraints, the text‐based measures developed by Hoberg and Maksimovic (2014). While the evidence supporting the limits‐to‐arbitrage hypothesis is stronger, there is a fair amount of evidence that financing constraints also reinforce the anomaly effect.
Biofuel Production With Sulfonated High Surface Area Carbons Derived From Glucose
Authors: Adhikari Shiba P. , Hood Zachary D. , Borchers Sara , Wright Marcus , Lachgar Abdou 
Published: January 2020

AbstractSolid acid carbon catalysts were prepared by activating hydrothermal carbon with potassium hydroxide (KOH) to form high surface area carbon and using an environmentally benign L‐cysteine method for subsequent sulfonation. The textural and physical properties of the solid acid catalysts were characterized by different techniques including Powder X‐ray diffraction (PXRD), Thermogravimetric analysis (TGA), Brunauer‐Emmett‐Teller (BET) surface area, Scanning electron microscopy (SEM), and X‐ray photoelectron spectroscopy (XPS) in order to understand the functionalization of sulfonic acids on the carbon support. The catalytic activity of the carbon‐based materials towards biofuel production was studied by using the esterification of oleic acid as a prime example. A quantitative yield of 95 % fatty acid methyl ester was achieved using the high surface area sulfonated catalyst (HSC‐SO3H with SA=1751 m2/g) at 80 °C for 4 hours at 1 atm with 10 wt. % of catalyst loading and at a 10 : 1 molar ratio of methanol/oleic acid. Sulfonation of carbon with L‐cysteine represents a promising technique to obtain solid acid catalysts, which are expected to be useful for other applications in Lewis‐acid catalysis, separations, and beyond.
A Catalyst‐Free Synthetic Route to Modified Isoflavone via Multi‐Component Reaction
Authors: Alizadeh Abdolali , Bagherinejad Akram 
Published: January 2020

AbstractA concise and efficient one‐pot sequential approach for the synthesis of modified isoflavone was developed from a reaction of 3‐formylchromones, malononitrile, various α,α‐dicyanoolefines, using Et3N as the base, and EtOH as the solvent, in good yield. The value of this method lies in its short reaction time, convenient purification, no need for a metal catalyst, excellent efficiency, and green solvent. This synthesis involves a Knoevenagel condensation/carbanion formation/ring closure, and finally, an elimination to obtain the respective isoflavonoid derivatives.