bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features of infertile men carrying a chromosome 9 translocation
Authors: Wang Ruixue , Yu Yang , Wang Qiyuan , Jiang Yuting , Li Linlin , Zhu Haibo , Liu Ruizhi , Zhang Hongguo 
Published: November 2019

AbstractPrevious studies indicated that chromosome 9 translocations are involved in reduced male fertility and increased chance of miscarriage in the female partner. The aim of this study was to review the clinical features and genetic counselling requirements of infertile men carrying chromosome 9 translocations. This study analyzed fertile-age male carriers of chromosome 9 translocations, and included 12 clinical cases in our hospital. In our cases, three cases had oligozoospermia or severe oligozoospermia, while nine cases had normal semen. Of the latter nine cases, seven were associated with recurrent spontaneous abortions, and two produced a phenotypically normal child as confirmed by amniocentesis. Male chromosome 9 translocations and specific breakpoints from reported papers were searched using PubMed and CNKI database. A literature review identified 76 male patients who carried chromosome 9 translocations. Breakpoints at 9p12, 9p11, 9p10 and 9q34.1 were related to pregestational infertility, while breakpoints at 9p21, 9q10, 9q11, 9q13, 9q21.1, 9q22, 9q22.2, 9q22.3, 9q34, 9q34.2 and 9q34.3 exhibited gestational infertility. Chromosome translocations involving chromosome 9 lead to increased risk of miscarriage. Carriers of chromosome 9 translocations should be counselled to consider in vitro fertilization accompanied by preimplantation genetic diagnosis.
„Mykener“ und Hethiter – ein archäologischer Vergleich
Authors: Mühlenbruch Tobias 
Published: November 2019

Zusammenfassung
Im 2. Jt. v. Chr. waren die mykenische Kultur, die in weiten Teilen der Südhälfte Griechenlands inklusive seiner Inselwelt verbreitet war, und das hethitische Reich, das seinen Kern in Anatolien hatte, zwar Nachbarn, standen auf der Basis der auf uns gekommenen Quellen jedoch in keinem intensiven Kontakt. Dies gilt für die materielle Kultur ebenso wie für die Schriftzeugnisse. Zudem fällt eine in mehreren Bereichen ausgesprochen unterschiedliche Quellenlage auf. Abweichend verliefen auch die Forschungsgeschichten zu beiden Regionen und sind auch die jeweiligen Forschungsansätze. Mit diesem Beitrag werden sowohl die mykenische wie die hethitische Kultur miteinander verglichen als auch deren Erforschung durch die Archäologie.
The chaîne opératoire of 6th millennium BC pottery making in the Maritsa Valley, Bulgaria: ceramics from Nova Nadezhda
Authors: Spataro Michela , Katsarov Georgi , Todorova Nadezhda , Tsurev Atanas , Nikolova Nikolina , Yaneva Marlena , Bacvarov Krum 
Published: November 2019

Abstract
40 potsherds and five other fired clay fragments from the prehistoric site of Nova Nadezhda in Bulgarian Thrace were analysed by archaeometric techniques. Twenty sherds and a daub fragment were analysed in thin section by optical microscopy; these thin sections, and thick sections of a further 24 sherds were also analysed by SEM-EDX. Results were used to describe the Early Neolithic chaîne opératoire at Nova Nadezhda, which was then compared to pottery production in roughly contemporaneous Starčevo-Criş communities in the central Balkans, to shed light on the Neolithisation process that took place in the 6th millennium BC. A variety of ceramic recipes was used to make different vessel shapes. Analyses of surface coatings were particularly enlightening in terms of provenance and the organisation of pottery production.
Wozu hütete Abel seine Schafe, wenn es keine Diebe gab? ‒ Altes und Neues zu Isaac La Peyrère und seiner Präadamiten-These (1655)
Authors: Jaumann Herbert 
Published: November 2019

Abstract
The two treatises of 1655, entitled Prae-Adamitae and Systema theologicum ex Praeadamitarum hypothesi, are among the principal works of the French Huguenot author Isaac La Peyrere (1596-1676). Peyrere ‘s theses have occupied a key position within the heretical branch of 17th-century Biblical Criticism: God must have created a human race before Adam, the Bible does not tell the history of mankind but of the elect people of Israel only, and the books of the Pentateuch were certainly not written, if at all, by Moses alone. The present contribution offers an outline of the recent La Peyrere Edition of 2019 and considers a few questions for further study. (1) How close are the Preadamites to early modern utopian literature? (2) What are we to make of Adriaan Beverland’s reference to the Praeadamitae in his infamous book on the Peccatum originale of 1678? (3) Taking up Isaac Popkin’s (1987) interesting suggestion, should we not as well consider a “pre-Eveite theory” alongside La Peyrere’s Preadamite hypothesis? This article concludes by addressing (4) another special desideratum: the early reception of La Peyrere and its continuing effects after the first critical responses as early as 1655/56.
Molecular Markers of Ischemic Stroke
Authors: Golubev A. M. , Petrova M. V. , Grechko A. V. , Zakharchenko V. E. , Kuzovlev A. N. , Ershov A. V. 
Published: November 2019

The purpose of the study was to evaluate the clinical significance of CNS biological markers in an ischemic stroke.Materials and methods. Blood serum biomarkers of CNS were assayed by ELISA in patients suffering from cerebrovascular disorders of ischemic origin. Neuron-specific enolase, brain-derived neutrophic factor (BDNF), glial-derived neutrophic factor (GDNF), protein S-100 total (ɑβ–ββ), sialyl carbohydrate antigen (KL-6), vascular endothelial growth factor, and superoxide dismutase were analyzed. All tests were carried out using automatic microplate immunoassay analyzer Immunomat TM. The study included 43 patients of 50 to 80 years of age, suffering from cerebrovascular disorders; among them there were 24 women and 19 men. Blood serum biomarkers of CNS were assayed within the first 3–6 hours, and on week 2, 3, and 4 from onset of the disease. The control group consisted of 20 volunteers (apparently healthy donors). Statistical analysis was carried out using non-parametrical Mann–Whitney test. Results were considered as significant at P 0.05.Results. During the pre-necrotic and early necrotic period, higher neuron-specific enolase, protein S-100, superoxide dismutase, and lower brain-derived neutrophic factor and glial-derived neutrophic factor were observed, reflecting structural brain alterations due to disturbed circulation. At later follow-up time-points, BDNF, GDNF, VEGF, and KL-6 increased evidencing activated CNS regeneration processes.Conclusion. The content of biological markers in blood serum of ischemic stroke patients reflects the disease stages, which helps managing the CNS regeneration processes.
The use of continuous Flow Ventilatory Support for Hypercapnic Respiratory Failure
Authors: Kapraľová P. , Žitva P. , Mišíková S. , Kočan L. , Firment P. 
Published: November 2019

Our aim was to assess the effectivity of continuous flow ventilatory support (CFVS) in those COPD patients undergoing cardiac surgery who developed hypercapnic respiratory failure.Materials and methods. CFVS was applied in 11 COPD (Stage 2.55±0.52 on average) patients undergoing cardiac surgery, after weaning from «conventional» pressure controlled (PCV) or pressure support ventilation (PSV) mode. All of these patients had hypercapnea with respiratory failure that has been manifested after 15±10 hours after postoperative weaning from ventilator. CFVS was applied using nasotracheal catheter (diameter 5–6 mm) with average inspiratory flow Qin = 26±2,3 l/min while using FiO2 of 0.3–0.35.Results. Only one out of 11 patients failed to recover from hypercapnic respiratory failure using CFVS and had to be intubated instead. Spontaneous ventilation frequency was gradually decreasing from 24.8±3.6 breaths/min to 16±2 breaths/min after initiation of CFVS (P<0.01). Average value of PaO2 before CFVS was 59±7.5 mmHg and rose to 99.6±4.5 mmHg just before CFVS was terminated (P<0.01). PaCO2 before CFVS was measured to be 73.2±7.5 mmHg and dropped to 45.7±4.3 mmHg (P<0.01). CO2 drop was fast in the first 18 hours from CFVS application. Average time for application of CFVS was 3.09±0.9 day.Conclusion. CFVS is an effective and minimally invasive mode of ventilation support that can be used in patients suffering from hypercapnic respiratory failure to avoid the need to intubate trachea and connect the patient to conventional ventilator.
Zolpidem Action During Prolonged Disorders of Consciousness (Case Report)
Authors: Kondratyeva E. A. , Sinkin M. V. , Sharova E. V. , Laureys S. , Kondratyev A. N. 
Published: November 2019

The paper describes two patients with prolonged disorders of consciousness (PDC) because of non-traumatic brain injury, in whom a clear neurodynamic response to Zolpidem was observed.In order to illustrate systemic cerebral responses to administration of this drug in LIC patients, an analysis of clinical and electrophysiological changes has been undertaken.It has been shown that the result of Zolpidem applications in patients with prolonged disorders of consciousness (PDC) should be assessed not only by consciousness dynamics, but with the help of electroencephalogram (EEG) monitoring, too. Distinct response to Zolpidem during different periods of recovery in one patients was found.Zolpidem can render various effects in patients in vegetative state/with unresponsive wakefulness syndrome (VS/UWS) and in minimally conscious state (MCS). In one patient, sedation with EEG activation was observed, which was a sign of favorable prognosis. The other patient developed more than once local convulsions after Zolpidem administration followed by contact augmentation on the next day.The mechanism of action, necessary doses of drugs, and markers of forecasting the successful effect of that drug are yet to be further studied.
Post-Stroke Thalamic Syndrome (Review)
Authors: Perepelitsa S. A. , Tumilovich T. A. , Shcherbakova A. A. 
Published: November 2019

Pain management is a foreground task of physicians specializing in various disciplines. Special attention is paid to the issues of early comprehensive rehabilitation of post-stroke patients and prophylaxis of probable long-term complications related to injuries of different brain structures.Post-stroke thalamic syndrome is the most frequent multiform complication that requires multidisciplinary efforts. Understanding of the morbid physiology of pain thalamic syndrome is the cornerstone of successful management providing higher quality of patients’ life. Currently, profound changes have taken place in the prophylaxis, diagnosis, and management of post-stroke thalamic syndrome. This review highlights the most common types of pain experienced by patients after thalamic stroke, presents morbid physiological mechanisms of pain development depending on the location of ischemic brain injury, and discusses the issues of up-to-date management and rehabilitation of post-stroke thalamic syndrome patients.
Composition and Age of Plagiogranitoids in the South of the Lake Zone (Western Mongolia)
Authors: Rudnev S.N. , Mal’kovets V.G. , Belousova E.A. , Tret’yakova I.G. , Gibsher A.A. 
Published: November 2019

Abstract
—We consider the geologic structure, composition, and age of early Paleozoic intrusive rock associations of the Tugrug, Udzur-Hunga, Hatan-Hunga, Mandalt, Bayasgalant, and Dut Uul plutons. The plutons are located among late Neoproterozoic–early Cambrian volcanic and volcanosedimentary strata in the southern part of the island-arc system of the Lake Zone in Western Mongolia. We have recognized plagiogranitoid and gabbroid associations of different petrochemical compositions, ages, and geodynamic settings of formation in these plutons. The results of geochronological studies show that the plagiogranitoid associations in the south of the Lake Zone formed in the period from 531 to 481 Ma. Two major stages of intrusive magmatism in the zone have been established in this time interval: island-arc, 531–517 Ma, and accretion–collision, 504–481 Ma. The plagiogranitoid associations that formed at the island-arc stage are the most widespread, whereas those formed at the accretion–collision stage are much scarcer. The intrusive plutons of all ages are composed predominantly of granitoid associations of the tonalite–trondhjemite series, which are calc-alkalic rocks. Study of xenogenic and inherited zircons from plagiogranitoid associations formed at the island-arc and accretion–collision stages of the regional evolution has shown their age range 664–520 Ma. Four age groups of inherited zircon have been recognized (~664, 570–560, 545–531, and 530–520 Ma), which generally correspond to the stages of island-arc (volcanic and intrusive) and ophiolite magmatism and, most likely, reflect the additional magma-generating sources of parental plagiogranitic melts.
A laikus elsősegély szerepe a kórházon kívüli keringésmegállások túlélésében
Authors: Diószeghy Csaba 
Published: November 2019

Abstract: Sudden cardiac death is one of the leading causes of mortality in developed countries. When happens only immediate action can save the patient’s life. A rather simple sequence of interventions (CPR – cardiopulmonary resuscitation) by the bystander witnessing the collapse could significantly increase the chance of survival yet it happens less than in half of the cases. One of the most important initiatives of the last decade was the simplification of basic life support guidelines and its trainings along with widely publicising its simplicity, importance and its effect on survival. The success of the initiative has been published by several studies showing an increasing number of bystander CPR worldwide, in Europe and in Hungary, too. Survival data have also increased moderately but by far not as much as it could be expected under ideal circumstances. This paper reviews the potential issues to be considered for increasing the numbers and improving the quality of bystander resuscitation. Orv Hetil. 2019; 160(46): 1810–1815.
Egy lehetséges iskolai „jógyakorlat” az újraélesztés kortársoktatásában. Egy egészségfejlesztési program első tapasztalatai
Authors: Fritúz Gábor , Gradvohl Edina , Feith Helga Judit , Lukács J. Ágnes , Falus András , Gál János 
Published: November 2019

Abstract: Basic life support (BLS) teaching by peer-educators to school-age students was studied by evaluating their effectiveness. BLS resuscitation was taught by the internationally accepted four-stage skill teaching approach. The effectiveness of the training was followed by sociological measuring instruments (n = 91). Compared to the students’ previous knowledge and attitudes about resuscitation, an increased willingness to adapt to an unexpected situation can be observed besides acquiring a reproducible method of CPR. The findings did not show significant age differences. Sensitivity and technical training in lay resuscitation is a successful educational process. The applied peer-education model is suitable for transferring resuscitation knowledge and skills. Orv Hetil. 2019; 160(46): 1816–1820.
A postresuscitatiós ellátás neuroprotekciós lehetőségei 2019-ben
Authors: Kovács Enikő , Gál János , Merkely Béla , Zima Endre 
Published: November 2019

Abstract: Post-resuscitation brain injury forms the leading cause of death of patients after successful cardiopulmonary resuscitation that explains why post-resuscitation neuroprotection is the most important part of post-resuscitation therapy. The goals of the neuroprotection tools available today are preventing the evolution of primary and formation of secondary brain injury. We are going to summarize the neuroprotective possibilities that we can reach today. We will discuss the role of pharmacologic strategies including sedation, the modalities of upholding brain perfusion, the monitoring of proper hemodynamic variables and the practice of targeted temperature management. It is very important to avoid hypo- and hyperoxia, to keep normocapnia, normoglycemia and to control seizures during the management of post-cardiac arrest patients. There is still a lack of evidence to prove which pharmacologic agent may be effective in postresuscitation neuroprotection, however, there are some promising results regarding thiamine. Hemodynamic management guided by higher level hemodynamic monitoring may be beneficial in enhancing brain perfusion but more clinical studies are needed to investigate its usefulness. Targeted temperature management constitutes the main element of post-resuscitation neuroprotection, however, the details of its implementation raise several questions. Orv Hetil. 2019; 160(46): 1832–1839.
Újraélesztést követő koszorúér-angiográfia és katéteres intervenció
Authors: Rudas László , Zima Endre 
Published: November 2019

Abstract: Out-of-hospital cardiac arrest (OHCA) presents a great challenge for the health care systems even in the highly developed countries. For several decades, our greatest efforts have been directed toward the improvement of the prehospital management, including promotion of lay resuscitation and deployment of public access automated defibrillators. Recently, the importance of the hospital phase of the OHCA-management has been also emphasized. Attention has been paid to targeted temperature management and also to early coronary intervention. For those patients who present with ST-elevation on their post-resuscitation ECG, our approach is straightforward: urgent coronary angiography is indicated. The optimal management of those survivors of OHCA who present without ST-elevation is, however, still debated. Although up to 30% of these subjects also suffer from acute occlusive epicardial coronary disease, the clear benefit of urgent coronary angiography for the whole group is yet to be documented. Several large-scale randomized studies are under way to resolve this question. In our present review we detail the above controversies and outline the future directions. Orv Hetil. 2019; 160(46): 1826–1831.
Az ultrahang használata az újraélesztésben
Authors: Kiss Domonkos 
Published: November 2019

Abstract: Cardiopulmonary resuscitation is one of the most emergent medical procedures. Maintaining our resuscitative efforts at the highest level possible is not only our professional, but also ethical duty. International scientific societies, like the European Resuscitation Council (ERC) and the American Heart Association (AHA) publish regularly their guidelines, based on robust scientific evidence, or (where it is not available) widely accepted expert panels’ opinion. Current clinical experience shows that a growing proportion of cardiac arrests is non-arrhytmogenic in origin. In these cases scientific guidelines, but also bare clinical judgement suggests searching for reversible causes and correcting them parallel with standard resuscitation efforts. Without this, a good outcome is rarely achievable. Intra-arrest protocolised ultrasound exam can be a powerful tool in detecting reversible causes, and also an aid in the correction of some. By reviewing the current literature and scientific guidelines, I aim to tailor the role and usefulness of intra-arrest ultrasound exam as an integrated part of the resuscitation efforts. Orv Hetil. 2019; 160(46): 1821–1825.
Um olhar histórico para o planejamento nacional da Educação no Brasil
Authors: Aquino Líbia Maria Serpa , Farenzena Nalú 
Published: November 2019

Resumo: O planejamento da educação de âmbito nacional no Brasil é o tema do artigo, que objetiva reconstruir traços marcantes da sua trajetória nos séculos XX e XXI, a culminar com a formulação da Lei do Plano Nacional de Educação (PNE) 2014-2024 no Congresso Nacional. Trata-se de um recorte de pesquisa sobre a formulação do atual PNE, para a qual foi elaborada uma contextualização histórica, em parte aqui apresentada. Realizou-se pesquisa de caráter bibliográfico e análise do conteúdo de documentos e proposições legais. Destaca-se a relevância da reconstrução histórica, pois possibilitou verificar continuidades e mudanças em processos e em conteúdos do planejamento da educação.Palavras-chave:Políticas Públicas de Educação; Plano Nacional de Educação; Planejamento Educacional; Formulação de Políticas Públicas; História do Planejamento da Educação.A HISTORICAL GLANCE AT THE NATIONAL EDUCATION PLANNING IN BRAZIL Abstract: This paper addresses the national education planning in Brazil. It is aimed at reconstructing remarkable features of its trajectory in the 20th and 21st centuries, resulting in the drawing up of the 2014-2024 National Education Plan Law (PNE) in the National Congress. The research focus emphasized the drafting of the current PNE; for such, a historical contextualization was developed, which is partially presented here. A bibliographic research and content analysis of legal documents and proposals were accomplished. It is highlighted the relevance of the historical reconstruction, as it allows to check continuities and changes in the contents of the education plan.Keywords: Education Public Policies; National Education Plan; Educational Planning; Public Policies Drawing Up; History of Education Planning.
Current Status and Future of Regional Seismic Network Monitoring in the Central and Eastern United States
Authors: Ebel John E. , Chapman Martin C. , Kim Won-Young , Withers Mitchell 
Published: November 2019

AbstractThe central and eastern United States (CEUS) is an area of generally low-to-moderate seismic hazard with a number of large cities with high seismic risk, a history of occasional damaging earthquakes, and seismic activity induced by wastewater disposal. Seismic monitoring in the CEUS, which began at the beginning 1900s, has undergone many changes through time. Over the past two decades, broadband digital seismic stations connected by internet communications have become widespread. Modern data processing systems to automatically locate earthquakes and assign event magnitudes in near-real time have become the norm, and, since the inception of the Advanced National Seismic System in 2000, more than 10,000 earthquakes have been located and cataloged. Continuously recorded digital seismic data at 100 samples per second are allowing new avenues of research into earthquake source parameters, ground-motion excitation, and seismic wave propagation. Unfortunately, over the past two decades the number of regional seismic network (RSN) centers has diminished due to consolidations and terminations, as funding has tightened. Nevertheless, the public in different parts of the CEUS still looks to local experts for information when earthquakes take place or when they have questions about earthquakes and seismic hazard. The current RSNs must evolve to encompass the need for local seismic information centers and to serve the needs of present and future research into the causes and effects of CEUS earthquakes.