bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune Checkpoint Inhibitor Therapy in Patients With Preexisting Inflammatory Bowel Disease
Authors: Abu-Sbeih Hamzah , Faleck David M. , Ricciuti Biagio , Mendelsohn Robin B. , Naqash Abdul R. , Cohen Justine V. , Sellers Maclean C. , Balaji Aanika , Ben-Betzalel Guy , Hajir Ibraheim , Zhang Jiajia , Awad Mark M. , Leonardi Giulia C. , Johnson Douglas B. , Pinato David J. , Owen Dwight H. , Weiss Sarah A. , Lamberti Giuseppe , Lythgoe Mark P. , Manuzzi Lisa , Arnold Christina , Qiao Wei , Naidoo Jarushka , Markel Gal , Powell Nick , Yeung Sai-Ching J. , Sharon Elad , Dougan Michael , Wang Yinghong 
Published: December 2019

PURPOSE The risk of immune checkpoint inhibitor therapy–related GI adverse events in patients with cancer and inflammatory bowel disease (IBD) has not been well described. We characterized GI adverse events in patients with underlying IBD who received immune checkpoint inhibitors. PATIENTS AND METHODS We performed a multicenter, retrospective study of patients with documented IBD who received immune checkpoint inhibitor therapy between January 2010 and February 2019. Backward selection and multivariate logistic regression were conducted to assess risk of GI adverse events. RESULTS Of the 102 included patients, 17 received therapy targeting cytotoxic T-lymphocyte antigen-4, and 85 received monotherapy targeting programmed cell death 1 or its ligand. Half of the patients had Crohn’s disease, and half had ulcerative colitis. The median time from last active IBD episode to immunotherapy initiation was 5 years (interquartile range, 3-12 years). Forty-three patients were not receiving treatment of IBD. GI adverse events occurred in 42 patients (41%) after a median of 62 days (interquartile range, 33-123 days), a rate higher than that among similar patients without underlying IBD who were treated at centers participating in the study (11%; P < .001). GI events among patients with IBD included grade 3 or 4 diarrhea in 21 patients (21%). Four patients experienced colonic perforation, 2 of whom required surgery. No GI adverse event–related deaths were recorded. Anti–cytotoxic T-lymphocyte antigen-4 therapy was associated with increased risk of GI adverse events on univariable but not multivariable analysis (odds ratio, 3.19; 95% CI, 1.8 to 9.48; P = .037; and odds ratio, 4.72; 95% CI, 0.95 to 23.53; P = .058, respectively). CONCLUSION Preexisting IBD increases the risk of severe GI adverse events in patients treated with immune checkpoint inhibitors.
Impact of Addition of Carboplatin AUC ≥ 4 to Antiemetic Guidelines for Triple Antiemetic Prophylaxis: A Gap in Quality of Care, Guideline Adoption, and Avoiding Acute Care
Authors: Navari Rudolph M. , Ruddy Kathryn J. , LeBlanc Thomas W. , Clark-Snow Rebecca , Wickham Rita J. , Binder Gary , Coberly Tammy , Potluri Ravi , Schmerold Luke M. , Roeland Eric J. 
Published: December 2019

PURPOSE: After ASCO and National Comprehensive Cancer Network guideline recommendations for triple antiemetic prophylaxis for carboplatin area under the curve (AUC) ≥ 4, and the publication of studies documenting avoidable acute care after chemotherapy involving nausea and vomiting (NV) and other toxicities, we studied clinician adherence to the guideline change and assessed avoidable acute-care use. METHODS: Using a large electronic health record database, we evaluated antiemetic prophylaxis as recommended in the guidelines and post-chemotherapy avoidable acute-care use (defined as involving any of NV or 8 other toxicities) for patients initiating carboplatin or other chemotherapy from October 2012 to August 2018. RESULTS: We identified 11,554 carboplatin courses. After the guideline change adding neurokinin-1 receptor antagonists (RAs) for carboplatin AUC ≥ 4, its use rose to 20% of courses from the prior average of 16%; virtually all courses also included a 5-HT3 RA plus dexamethasone. We found avoidable acute care in 23% of courses; one quarter of these events were associated with NV. Acute care rates after carboplatin mirrored those after other highly emetogenic chemotherapy or oxaliplatin and exceeded those after other chemotherapy regimens. The > 80% shortfall in adherence may have been caused by low awareness or acceptance of the guideline change and/or by poor awareness of avoidable acute-care use after carboplatin. CONCLUSION: Neurokinin-1 RA prophylaxis for carboplatin AUC ≥ 4 remains low and largely unchanged despite National Comprehensive Cancer Network and ASCO 2017 recommendations for inclusion. NV and avoidable acute care involving NV seen after carboplatin were consistent with other highly emetogenic chemotherapy. Clinician action is required to remediate incomplete prophylaxis and to no longer place patient outcomes, resources for cancer treatment, and clinician reimbursement at risk.
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells
Authors: Zhang Irina X , Raghavan Malini , Satin Leslie S 
Published: December 2019

Abstract
The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the secretory pathway and is the site where protein folding and quality control are initiated. The storage and release of Ca2+ are critical physiological functions of the ER. Disrupted ER homeostasis activates the unfolded protein response (UPR), a pathway which attempts to restore cellular equilibrium in the face of ER stress. Unremitting ER stress, and insufficient compensation for it results in beta-cell apoptosis, a process that has been linked to both type 1 diabetes (T1D) and type 2 diabetes (T2D). Both types are characterized by progressive beta-cell failure and a loss of beta-cell mass, although the underlying causes are different. The reduction of mass occurs secondary to apoptosis in the case of T2D, while beta cells undergo autoimmune destruction in T1D. In this review, we examine recent findings that link the UPR pathway and ER Ca2+ to beta cell dysfunction. We also discuss how UPR activation in beta cells favors cell survival versus apoptosis and death, and how ER protein chaperones are involved in regulating ER Ca2+ levels.
Abbreviations: BiP, Binding immunoglobulin Protein ER; endoplasmic reticulum; ERAD, ER-associated protein degradation; IFN, interferon; IL, interleukin; JNK, c-Jun N-terminal kinase; KHE, proton-K+ exchanger; MODY, maturity-onset diabetes of young; PERK, PRKR-like ER kinase; SERCA, Sarco/Endoplasmic Reticulum Ca2+-ATPases; T1D, type 1 diabetes; T2D, type 2 diabetes; TNF, tumor necrosis factor; UPR, unfolded protein response; WRS, Wolcott–Rallison syndrome.
The Curious Case of Baruch Spinoza in Walter Benjamin's “Toward the Critique of Violence”
Authors: Palma Massimo 
Published: December 2019

Abstract
Although Baruch Spinoza was important for thinkers of his generation, Walter Benjamin seems to have completely ignored the philosopher. Spinoza's name appears just a few times in Benjamin's works, and Spinoza's thought never seems to have been relevant to him. The only place where Benjamin quotes a text of Spinoza's, albeit between the lines, is in “Toward the Critique of Violence” (1921). Still, in this essay Benjamin is far from enthusiastic about the author of the Ethics. He names Spinoza as a proponent of natural law theory, which Benjamin dismisses in his search for a criterion with which to judge Gewalt. This article seeks to investigate Benjamin's apparent hostility to Spinoza and to reexamine the relationship between the two, from both a theoretical and a political perspective.
Synthesis, Structure, and Reactivity of a Thermally Stable Dialkylgermylene
Authors: Suzuki Fumiaki , Nishino Ryohei , Yukimoto Mariko , Sugamata Koh , Minoura Mao 
Published: December 2019

Abstract
The dialkylgermylene Trp*2Ge: (Trp*: peripherally extended sterically demanding alkyl groups based on the triptycyl (Trp) framework), was obtained from the reaction of Trp*Li with GeCl2·dioxane. The structure of Trp*2Ge: was unequivocally determined by NMR and UV-vis spectroscopy, mass spectrometry, and a single-crystal X-ray diffraction analysis. Moreover, the reactivity of Trp*2Ge: was examined.
On the predictability of high and low prices: The case of Bitcoin
Authors: Maciel Leandro dos Santos , Ballini Rosangela 
Published: December 2019

Bitcoin has attracted the attention of investors lately due to its significant market capitalization and high volatility. This work considers the modeling and forecasting of daily high and low Bitcoin prices using a fractionally cointegrated vector autoregressive (FCVAR) model. As a flexible framework, FCVAR is able to account for two fundamental patterns of high and low financial prices: their cointegrating relationship and the long memory of their difference (i.e., the range), which is a measure of realized volatility. The analysis comprises the period from January 2012 to February 2018. Empirical findings indicate a significant cointegration relationship between daily high and low Bitcoin prices, which are integrated on an order close to the unity, and the evidence of long memory for the range. Results also indicate that high and low Bitcoin prices are predictable, and the fractionally cointegrated approach appears as a potential forecasting tool forcryptocurrencies market practitioners.
Influence of dephasing on the Akaike-information- criterion distinguishing of quantum interference and Autler–Townes splitting in coherent systems
Authors: Liu Jinhong , Wu Jinze , Zhang Yueying , He Yanyan , Zhang Junxiang 
Published: December 2019

Electromagnetically induced transparency is a quantum interference (QI) effect in a coherent system, in which the similar but distinct effect of Autler–Townes splitting (ATS) without QI also happens concurrently. The Akaike information criterion (AIC) has been proven to be an efficient and objective method to discern them by evaluating their relative AIC weights for different Rabi frequencies of the coupling field. Here, we investigate in detail the influence of the dephasing effect on the AIC weights of QI and ATS, and present the transition among destructive QI, constructive QI, and ATS without QI by controlling the dephasing rates. By comparing the effects of different dephasing rates on the QI and ATS weights, we show that the field-phase-diffusion dephasing provides more feasibility than the atom-collision dephasing in control of QI and ATS. Therefore, precise and selective dephasing engineering can be realized by manipulating the linewidths and phase correlation of the fields. This indicates that various collision-related effects (e.g., collision-dephasing-induced coherences) can be experimentally studied using more controllable field-phase-diffusion dephasing instead of buffer-gas-controlling collision dephasing.
Beyond 53% internal quantum efficiency in a AlGaN quantum well at 326  nm UVA emission and single-peak operation of UVA LED
Authors: Khan M. Ajmal , Takeda Ryohei , Yamada Yoichi , Maeda Noritoshi , Jo Masafumi , Hirayama Hideki 
Published: December 2019

AlGaN-based ultraviolet-A (UVA) light-emitting-diodes (LEDs) at emission under 330 nm are of great importance for numerous applications, including medicine and photochemical technologies. In this Letter, a highly relaxed n-AlGaN electron injection layer (EIL) underneath the multi-quantum wells (MQWs) for the suppression of both threading dislocation densities and piezoelectric effect was attempted. When the Ga-rich n-AlGaN EIL in the UVA LED was relaxed up to 75%, the full width at half-maximum values of the X-ray rocking curves for the (10–12) planes were reduced from our previous value of approximately 793 to 564 arcsec. Subsequently, a maximum light power of 3.1 mW was achieved in the 326 nm band UVA LED. However, carrier confinement and transport issues in the MQWs were observed. To resolve these issues of carrier confinement and transport, we provide a short roadmap for experimental efforts to realize an internal quantum efficiency (IQE) beyond 53% in AlGaN UVA-MQWs.
Cross-stacking of guided-mode resonance gratings for polarization-independent flat-top filtering
Authors: Kawanishi Keisuke , Shimatani Akira , Lee Kyu Jin , Inoue Junichi , Ura Shogo , Magnusson Robert 
Published: December 2019

A guided-mode resonance filter (GMRF) consists of a subwavelength grating on a thin-film waveguide and can provide narrowband filtering with fewer layers in contrast to a multilayer dielectric mirror. A GMRF normally shows a peaky reflection spectrum and polarization dependency. In this Letter, two GMRFs are orthogonally stacked to give polarization-independent narrowband flat-top filtering. The GMRFs are designed by numerical methods and then fabricated and stacked. Each GMRF is formed by corrugation of a

T
i
O

2

grating layer on a SiN guiding core layer on a

S
i
O

2

substrate. A narrowband flat-top filter is demonstrated with a 7 nm full-width at half-maximum.
Frequency comb dynamics of a 1.3µm hybrid-silicon quantum dot semiconductor laser with optical injection: erratum
Authors: Dong Bozhang , Huang Heming , Duan Jianan , Kurczveil Geza , Liang Di , Beausoleil Raymond G. , Grillot Frédéric 
Published: December 2019

In Opt.
Lett. 44, 5755
(2019)OPLEDP0146-959210.1364/OL.44.005755, a factor is missing
in the result of Eq. (1). Thus, the width of the comb spectrum

Δ
ν

becomes

Δ
ν
=
2

3

Γ

α
e

.
Sporadic Porphyria Cutanea Tarda as the Initial Manifestation of Hereditary Hemochromatosis
Authors: Edwards Mitchell V. , Ray Jennifer Michelle , Bacon Bruce R. 
Published: December 2019

ABSTRACT
Porphyria cutanea tarda (PCT) is a skin disorder characterized by abnormal heme synthesis. We present a 45-year-old man with intermittent skin lesions recurring annually for years. Skin biopsy and measurement of serum heme precursors confirmed a diagnosis of PCT. He had persistently elevated alanine and aspartate transferase. He was referred to hematology and had genetic testing with iron studies which also revealed hereditary hemochromatosis (HH). Therapeutic phlebotomy was initiated, which led to resolution of iron overload and skin lesions. We highlight the associated conditions of PCT and HH, their common therapy of phlebotomy, and initial manifestations of HH.
Successful Endoscopic Closure of Pyeloduodenal Fistula Using an Over-the-Scope Clip
Authors: Duh Erica , Clary Meredith , Samarasena Jason , Clayman Ralph V. , Chang Kenneth 
Published: December 2019

ABSTRACT
A 62-year-old woman underwent a series of urologic procedures for nephrolithiasis and was diagnosed with a pyeloduodenal fistula (PDF) on computed tomography urography. After the placement of a metallic ureteral stent and nephrostomy tube, an esophagogastroduodenoscopy was performed to evaluate for PDF resolution. Two areas of mucosal defects within the anterior duodenal sweep were closed using the over-the-scope clip system and hemostasis clips. We review the literature and discuss the etiologies, presentation, diagnosis, and treatment of PDF. This is the second documented case of endoscopic PDF closure using the over-the-scope clip system and the third case of endoscopically treated PDF.
Randomized Clinical Trial: Crofelemer Treatment in Women With Diarrhea-Predominant Irritable Bowel Syndrome
Authors: Nee Judy , Salley Katherine , Ludwig Andrew G. , Sommers Thomas , Ballou Sarah , Takazawa Eve , Duehren Sarah , Singh Prashant , Iturrino Johanna , Katon Jesse , Lee Ha-Neul , Rangan Vikram , Lembo Anthony J. 
Published: December 2019

INTRODUCTION:
Crofelemer, the active compound purified from latex of Croton lechleri, has been shown to improve HIV and traveler's diarrhea and improve pain in women with irritable bowel syndrome–diarrhea (IBS-D). This trial evaluated the effect of crofelemer on abdominal pain in women with IBS-D.

METHODS:
Women with IBS-D were randomized to crofelemer (125 mg) or placebo twice daily for 12 weeks. The primary efficacy endpoint was overall change in percentage of abdominal pain/discomfort-free days. Post hoc analysis for Food and Drug Administration (FDA) monthly responders was performed for stool consistency, abdominal pain, and combined stool consistency and abdominal pain.

RESULTS:
A total of 240 women were enrolled. There was no significant difference in overall percentage of pain/discomfort-free day between the groups. In post hoc analysis, FDA abdominal pain monthly responders were significantly more likely during months 1 through 2 (58.3% vs 45.0%, P = 0.030) as well as during the entire 3 months (54.2% vs 42.5%, P = 0.037) in the crofelemer group when compared with placebo. However, there was no significant difference in the percentage of FDA stool consistency monthly responders or combined stool consistency and pain monthly responders between the groups. Crofelemer had a safety profile similar to placebo.

DISCUSSION:
Crofelemer did not significantly improve abdominal pain over placebo by the primary endpoint. However, it did based on the FDA abdominal pain monthly responder endpoint. This suggests that crofelemer may have a role in the treatment of abdominal pain associated with IBS-D. Further studies are warranted to evaluate the potential of crofelemer as a visceral analgesic.
Tiga Perempuan Pengusaha Batik: Kajian Peran Sosial Ekonomi Perempuan Pengusaha Batik di Kampung Batik Bubakan, Kelurahan Rejomulyo Semarang
Authors: Amalia Silfa , Suyanto Suyanto , Hendro Eko Punto 
Published: December 2019

AbstrakPartisipasi perempuan dalam pembangunan sangat diperlukan, baik dalam rumah tangga maupun dalam kehidupan bermasyarakat dan bernegara. Keterlibatan wanita dalam kerja produktif akan menimbulkan perubahan sosial, karena salah satu wujud perubahan sosial adalah perubahan dalam kerja, khususnya untuk wanita di Jawa. Tujuan penelitian ini adalah untuk mengetahui faktor pendorong perempuan menjadi pengusaha batik, mengetahui peranan sosial ekonomi perempuan pengusaha batik, baik dalam kegiatan rumah tangga, masyarakat maupun kegiatan usaha batik, serta mengetahui proses pengambilan keputusan dan pengalokasian waktu para perempuan pengusaha batik. Teori yang digunakan dalam penelitian ini adalah teori kebutuhan dan prestasi dari David McClelland dan teori peran perempuan oleh Caroline O.N. Moser. Penelitian ini dilakukan dengan metode observasi partisipan dan menggunakan pendekatan kualitatif. Teknik pengumpulan data yang dilakukan adalah dengan menggunakan observasi (pengamatan), wawancara mendalam, dokumentasi, studi literatur dan triangulasi. Informan berjumlah tiga orang yang diperoleh dengan kriteria perempuan yang memiliki home industry/ usaha batik. Berdasarkan penelitian yang dilakukan dapat disimpulkan bahwa perempuan tidak hanya memainkan peranannya sebagai ibu rumah tangga, mereka juga banyak terlibat dalam kegiatan usaha dan aktif dalam kegiatan sosial kemasyarakatan. Dalam pengalokasian waktu diketahui beban kerja perempuan lebih panjang. Bahkan perempuan pengusaha batik memegang peranan sentral dalam hal pengambilan keputusan dalam perekonomian rumah tangga.Abstract Women's participation in the development of household, social life, and country life is most needed. Women's involvement in productive work will lead to social change due to a kind of social change is change in the work, especially for women in Java. The aims of this study are to find out the supporting factors of women being Batik businesswomen, a socio-economic role of batik businesswomen in household, society, or business activity of Batik, the decision making process, and time allocation of Batik businesswomen. The theories of this study are needs and achievements theory of David Mc Clelland and role theory of Caroline O.N Moser. This study was conducted by using participant observation method and qualitative approach. The data collection techniques are observation, in-depth interview, documentation, literature study, and triangulation. The Informants are three women obtained by the criteria of women who have home industry or Batik industry. Based on this study can be concluded thatwomen are not only having a role in housewives but also they have involvement in a business activity or social. In allocating time it is known that women’s workload is longer. Even women batik entrepreneurs hold a central role in terms of decision making in the household economy.
Pengaruh Structural Assurance dan Perceived Reputation Terhadap Purchase Intention Melalui Trust Pada Konsumen Tokopedia
Authors: Saputra Moh. Deni Andri , Widiartanto Widiartanto 
Published: December 2019

The aims of this study is to measure the effects of structural assurance and perceived reputation to purchase intention through trust. The population of this research is consumers of Tokopedia in Faculty of Social and Political Science of Diponegoro University, while the sample is 100 consumers of Tokopedia with some certain prerequirements.The data was analyzed using two-step analysis with SPSS 17.0 for windows where previously tested the validity test, reliability test, coefficient of correlation, coefficient of determination, and test of significance (t-test and f-test). The result of this study is showing that structural assurance and perceived reputation has positive impact toward trust, the biggest impact is own by perceived reputation. Based on the result of two step analysis, trust is an intervening variable toward purchase intention in this study. Some recommendations are added based on those results. It is recommended that Tokopedia should improve the ability to solve hacking, provide guaranteed data information so that visitors' responses to structural assurance are safe, besides that it needs to focus on customer satisfaction, provide high service and increase credibility so consumers arise trust and increase purchase intention to Tokopedia. Tujuan dilakukanya penelitian ini adalah untuk mengetahui pengaruh antara structural assurance dan perceived reputation terhadap purchase intention melalui trust. Populasinya adalah seluruh konsumen Tokopedia di Fakultas Ilmu Sosial dan Ilmu Politik di Universitas Diponegoro, sedangkan sampelnya adalah 100 konsumen Tokopedia dengan kriteria tertentu. Analisis yang digunakan dalam penelitian ini adalah analisis dua tahap menggunakan software SPSS for Windows, di mana sebelumnya dilakukan uji validitas, uji reliabilitas, uji koefisien korelasi, koefisien determinasi, analisis regresi sederhana dan berganda, dan uji signifikansi (uji t dan uji F). Hasil penelitian ini menunjukan bahwa structural assurance dan perceived reputation berpengaruh secara parsial dan simultan terhadap trust, dimana ketika bersama-sama perceived reputation memiliki pengaruh yang paling besar terhadap trust. Berdasarkan hasil analisis dua tahap trust merupakan variabel intervening terhadap purchase intention dalam penelitian ini. Berdasarkan hasil tersebut maka disarankan supaya Tokopedia dapat meningkatkan kemampuan dalam memecahkan masalah hackers, menyediakan jaminan informasi data sehingga tanggapan pengunjung mengenai structural assurance aman, selain itu perlu memfokuskan terhadap kepuasan konsumen, memberikan pelayanan yang tinggi dan meningkatkan kredibilitas yang dimiliki sehingga konsumen timbul trust dan berminat untuk membeli di Tokopedia.