bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Citra Merek Melalui Sikap Konsumen Terhadap Niat Beli Ulang Pada Produk Busana Muslim Zoya di Surabaya
Authors: Ain Nurul , Ratnasari Ririn Tri 
Published: October 2020

This study aims to determine the effect of brand image to re-purchase intention through attitude of consumers to the brand in the Zoya’s Muslim fashion products in Surabaya.This sudy collects primary data from the questionere with 30 sample. The sample is the consumer of Zoya’s products in Surabaya. This study utilizes Consumer characteristics who have ever made a purchase Zoya’s products in Surabaya within the past year. The sampling technique is accidental and purposive sampling.This study utilizes quantitative approach path analysis technique (path analysis).Endogenous variables is re-purchase intention, whereas exogenous variables is brand image and intervening endogenous variable is the attitude of consumers to the brand image. The results indicates that the brand image has a positive and significant impact to the consumer attitudes on Zoyas’s Muslim fashion brand. Other results shows that a significant influence on consumer attitudes and re-purchase intention . Then, the brand image is also has positive and significant impact on re-purchase intention on the Zoya’s Muslim fashion in Surabaya. Based on these findings, Zoya Surabaya branch should maintain and enhance the brand image of Zoya and positive attitudes of consumers towards the Muslim fashion Zoya so as to improve on the consumer's purchase intention on products Moslem Zoya. For the further research, it will be better by adding a moderator variables such as the level of religious knowledge that will get an idea whether the moderator variables will weaken or increase the influence of consumer attitudes to re-purchase intention of consumers on Zoyas’s Muslimfashion brand.
Pengaruh Price Earning Ratio (PER), Price Book Value (PBV) dan Debt to Equity Ratio (DER) Terhadap Return Saham (Studi Terhadap Perusahaan Properti dan Real Estate yang Listing di Indeks Saham Syariah Indonesia)
Authors: Akbar Rendra , Herianingrum Sri 
Published: October 2020

Every investor wants a secure investment and provides profit (in-return). This study aimed to analyze the effect of Price Earnings Ratio (PER), Price Book Value (PBV) and Debt to Equity Ratio (DER) on stock returns Vendor property and real estate listed in Indonesian Sharia Stock Index (ISSI) in the period 2011-2013. This study used quantitative analysis with panel data estimation methods with time series in 2011-2013 and cross section data of thirty-one companies used α = 5% significance level. The regression results in this study indicated that the independent variables Price Earnings Ratio (PER) and variable Debt to Equity Ratio (DER) significantly shown negative effect on stock returns, meanwhile the variable Price Book Value (PBV) significantly shown positive effect on stock returns. While simultaneously brought a significant effect on stock returns and real estate properties listed in Indonesian Sharia Stock Index (ISSI) in period 2011-2013.
Study of Pasture Productivity for Semi-Intensive Cattle System during Dry Season in the South Konawe Regency, Southeast Sulawesi
Authors: Sulfiar Ahmat Endang Two , Atmoko Bayu Andri , Guntoro Budi , Budisatria I Gede Suparta 
Published: October 2020

This study was aimed to evaluate the characteristics and productivity of pasture for semi-intensive cattle system in South Konawe Regency during dry season. The study was conducted in August-September 2019 as dry season based on the weather condition and was determine by Department of Statistics Center of South Konawe Regency. A total of 55 selected smallholder farmers in two areas in South Konawe Regency, namely West Ranomento (30) and Konda (25) Districts. Data were obtained by interview to find out the farmers profile and pasture characteristics. Production was measured by forage sampling (1x1m) to calculate annual production. Samples were proximately analyzed to calculate dry matter production and the carrying capacity. Data were analyzed descriptively and statistically with an independent sample t-test. The botanical composition in both locations was highly dominated (>90%) by field grasses. The grassland ownership was not different between two areas. Grassland ownership at West Ranomento and Konda were 0.78±0.14 and 0.21±0.04 Ha/farmer, respectively. The pasture production between West Ranomento (2.27±0.10 ton/ha) and Konda District (1.76±0.05 ton/ha) was significantly different (p<0.05),. Pasture production and carrying capacity indicated that conditions in West Ranomento were significantly higher (p<0.05) compared to Konda District. The fresh forages production was 10.98±2.26 vs. 2.17±0.51 ton/year, forages that can be consumed was 3.30±0.67 vs. 3.30±0.67ton/year, dry matter production was 0.72±0.15 vs. 0.18±0.04 ton/year and carrying capacity was 0.22±0.04 vs. 0.05±0.01 AU/year respectively. It was concluded that the pasture productivity at the study area during dry season was very low based on productivity and carrying capacity.
Variation in the expression of a transmembrane protein influences cell growth in Arabidopsis thaliana petals by altering auxin responses
Authors: Miller Charlotte N. , Dumenil Jack , Lu Fu Hao , Smith Caroline , McKenzie Neil , Chapman Volodymyr , Ball Joshua , Box Mathew , Bevan Michael Webster 
Published: October 2020

Abstract
AbstractBackground. The same species of plant can exhibit very diverse sizes and shapes of organs that are genetically determined. Characterising genetic variation underlying this morphological diversity is an important objective in evolutionary studies and it also helps identify the functions of genes influencing plant growth and development. Extensive screens of mutagenised Arabidopsis populations have identified multiple genes and mechanisms affecting organ size and shape, but relatively few studies have exploited the rich diversity of natural populations to identify genes involved in growth control. Results. We screened a relatively well characterised collection of Arabidopsis thaliana accessions for variation in petal size. Association analyses identified sequence and gene expression variation on chromosome 4 that made a substantial contribution to differences in petal area. Variation in the expression of a previously uncharacterised gene At4g16850 (named as KSK) had a substantial role on variation in organ size by influencing cell size. Over-expression of KSK led to larger petals with larger cells and promoted the formation of stamenoid features. The expression of auxin-responsive genes known to limit cell growth was reduced in response to KSK over-expression. ANT expression was also reduced in KSK over-expression lines, consistent with altered floral identities. Auxin responses were reduced in KSK over-expressing cells, consistent with changes in auxin-responsive gene expression. KSK may therefore influence auxin responses during petal development.Conclusions. Understanding how genetic variation influences plant growth is important for both evolutionary and mechanistic studies. We used natural populations of Arabidopsis thaliana to identify sequence variation in a promoter region of Arabidopsis accessions that mediated differences in the expression of a previously uncharacterised membrane protein. This variation contributed to altered auxin responses and cell size during petal growth.
Longitudinal trajectory of disability in community-dwelling older adults: An observational cohort study in South Korea
Authors: Kim Hae Reong , Lee Hea yon , Seong Yoonje , Lee Eunju , Jung Hee-Won , Park Yu Rang , Jang Il-Young 
Published: October 2020

Abstract
Background: Disability, which is considered a health-related condition, increases care demands and socioeconomic burdens for both families and communities. To confirm the trend of dynamic longitudinal changes in disability, this study aims to explore how disability is divided by the trajectory method, which deals with time-sequenced data. Additionally, this study examines the differences in demographics, geriatric conditions, and time spent at home among the trajectory groups in community-dwelling older adults. Home time is defined as the period during which the patient was not in a hospital or health care facility during their lifetime.Methods: Records of 786 community-dwelling older participants were analyzed from the Aging Study of PyeongChang Rural Area, a population-based cohort study that took place over three years. Using 7 domains of activities of daily living and 10 domains of instrumental activities of daily living, participants were grouped into no dependency (0 disabled domain), mild (1 disabled domain), and severe (2 or more disabled domains) disability groups. The longitudinal trajectory group of disability was calculated as a trajectory method. Three distinct trajectory groups were calculated over time: a relatively-stable group (78.5 %; n=617), a gradually-aggravated group (16.0 %; n=126), and a rapidly-deteriorated group (5.5 %; n=43).Results: The average age of 786 participants was 73.3 years (SD: 5.8), and the percentage of female was 52.7%. It was found that 78.5% of patients showed relatively no dependence and 5.5% of older adults in a rural area showed severe dependence. Through applying the trajectory method, it was shown that the Short Physical Performance Battery (SPPB) score was 10.2 points in the relatively-stable group and 3.1 points in the rapidly-deteriorating group by the 3rd year. Additionally, by the trajectory method, the rate of decrease in home time was 3.33% in the rapidly-deteriorated group compared to the relatively-stable group.Conclusions: This study shows the difference in demographics and geriatric conditions (such as SPPB) through the examination of longitudinal trajectory groups of disability in community-dwelling older adults. Significant differences were also found in the amount of home time among the trajectory groups.
ESCRT machinery plays a role in microautophagy in yeast
Authors: Morshed Shamsul , Tasnin Most Naoshia , Ushimaru Takashi 
Published: October 2020

Abstract
Background: Microautophagy, which degrades cargos by direct lysosomal/vacuolar engulfment of cytoplasmic cargos, is promoted after nutrient starvation and the inactivation of target of rapamycin complex 1 (TORC1) protein kinase. In budding yeast, microautophagy has been commonly assessed using processing assays with green fluorescent protein (GFP)-tagged vacuolar membrane proteins, such as Vph1 and Pho8. The endosomal sorting complex required for transport (ESCRT) system is proposed to be required for microautophagy, because degradation of vacuolar membrane protein Vph1 was compromised in ESCRT-defective mutants. However, ESCRT is also critical for the vacuolar sorting of most vacuolar proteins, and hence reexamination of the involvement of ESCRT in microautophagic processes is required.Results: Here, we show that the Vph1-GFP processing assay is unsuitable for estimating the involvement of ESCRT in microautophagy, because Vph1-GFP accumulated highly in the prevacuolar class E compartment in ESCRT mutants. In contrast, GFP-Pho8 and Sna4-GFP destined for vacuolar membranes via an alternative adaptor protein-3 (AP-3) pathway, were properly localized on vacuolar membranes in ESCRT-deficient cells. Nevertheless, microautophagic degradation of GFP-Pho8 and Sna4-GFP after TORC1 inactivation was hindered in ESCRT mutants, indicating that ESCRT is indeed required for microautophagy after nutrient starvation and TORC1 inactivation.Conclusions: These findings provide evidence for the direct role of ESCRT in microautophagy induction.
Viral load Guided Immunosuppression after Lung Transplantation (VIGILung) – study protocol for a randomized controlled trial
Authors: Gottlieb Jens , Reuss Alexander , Mayer Konstantin , Weide Karin , Schade-Brittinger Carmen , Hoyer Susanne , Jaksch Peter 
Published: October 2020

Abstract
Background:Immunosuppression including high dose calcineurin-inhibitors (CNI) is essential after lung transplantation. Dosing is usually guided by therapeutic drug monitoring adjusted to target trough levels of CNIs to keep the balance between over-dose causing severe toxicity and increased risk of infections or under-dose with risk of graft-injury.Adaptation of CNI-based immunosuppression by monitoring of Torque-Teno-Virus (TTV) – a latent nonpathogenic DNA virus, measured in whole blood in addition to conventional therapeutic drug monitoring may reduce toxicity of immunosuppression with similar efficacy.Methods/Design:An open-label, randomized, controlled, parallel-group, multicenter trial in lung transplant recipients will be conducted to investigate the safety and efficacy of immunosuppression guided by TTV monitoring as add-on to conventional therapeutic drug monitoring. Adult lung transplant recipients 21 - 42 days after transplantation are eligible to participate. Patients (N = 144) will be randomized 1:1 to the experimental intervention (Arm 1: Immunosuppression guided by TTV monitoring in addition to conventional therapeutic drug monitoring of tacrolimus trough levels) and control intervention (Arm 2: conventional therapeutic drug monitoring). Outcomes will be assessed 12 months after randomization with the change in glomerular filtration rate as the primary endpoint. Secondary endpoints will be additional measurements on renal function, allograft function, incidence of acute rejections, incidence of chronic lung allograft dysfunction, graft loss and infections.Discussion:The results of this randomized controlled trial may reduce toxicity of immunosuppression after lung transplantation while maintaining efficacy of immunosuppression. Study results are transferable to all other solid organ transplantations.Trial registration: ClinicalTrials.gov, NCT04198506. Registered 12 December 2019, https://www.clinicaltrials.gov/show/NCT04198506
Serum copeptin and zinc-α2-glycoprotein levels are novel biomarkers of tolvaptan treatment in decompensated cirrhotic patients with ascites.
Authors: Shigefuku Ryuta , Iwasa Motoh , Eguchi Akiko , Tempaku Mina , Tamai Yasuyuki , Suzuki Tatsuya , Takei Yoshiyuki 
Published: October 2020

Abstract
Background: The efficacy of tolvaptan, an orally active vasopressin V2-receptor antagonist, has recently been reported in patients with massive ascites unresponsive to conventional diuretics. However, the effect of tolvaptan varies among patients. Recently, the prognostic role of tolvaptan response in decompensated liver cirrhosis (LC) has started to attract more attention. Our aim is to elucidate predictive factors using serum copeptin (vasopressin precursor), zinc-α2-glycoprotein (ZAG), cystatin C (renal biomarker), neutrophil gelatinase-associated lipocalin (NGAL) and liver-type fatty acid-binding protein (L-FABP) that portend a good response to tolvaptan in LC patients with ascites.Methods: We enrolled 113 LC patients and divided into tolvaptan treatment group and non-treatment group. Tolvaptan (3.75 or 7.5 mg/day) was administrated to 38 LC patients with ascites and a follow-up assessment occurred after a 7-day tolvaptan treatment regimen. Results: We revealed predictive ability for kidney and/or liver damage in serum copeptin, ZAG, cystatin C, NGAL and L-FABP levels in all patients. Post 7-day tolvaptan treatment, 19 patients lost more than 1.5 kg of their body weight (Responders), while 19 patients did not change their body weight significantly (Non-responders). Basal blood urea nitrogen (BUN) (p=0.0014), serum copeptin (p=0.0265) and serum ZAG levels (p=0.0142) were significantly higher in the Non-responders. BUN (odds ratio 7.43, p=0.0306), copeptin (odds ratio 9.12, p=0.0136) and ZAG (odds ratio 7.43, p=0.0306) were determined to be predictive factors of drug responsiveness using multivariate logistic regression analysis.Conclusion: Serum BUN, copeptin and ZAG levels predict patient response to tolvaptan even when measured prior to treatment.
The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury
Authors: Murugan Madhuvika , Zheng Jiaying , Wu Gongxiong , Mogilevsky Rochelle , Zheng Xin , Hu Peiwen , Wu Junfang , Wu Long-Jun 
Published: October 2020

Abstract
Traumatic injury to the spinal cord initiates a series of pathological cellular processes that exacerbate tissue damage at and beyond the original site of injury. This secondary damage includes oxidative stress and inflammatory cascades that can lead to further neuronal loss and motor deficits. Microglial activation is an essential component of these secondary signaling cascades. The voltage-gated proton channel, Hv1, functionally expressed in microglia has been implicated in microglia polarization and oxidative stress in ischemic stroke. Here, we investigate whether Hv1 mediates microglial/macrophage activation and aggravates secondary damage following spinal cord injury (SCI). Following contusion SCI, wild-type (WT) mice showed significant tissue damage, white matter damage and impaired motor recovery. However, mice lacking Hv1 (Hv1-/-) showed significant white matter sparing and improved motor recovery. The improved motor recovery in Hv1-/- mice was associated with decreased interleukin-1β, reactive oxygen/ nitrogen species production and reduced neuronal loss. Further, deficiency of Hv1 directly influenced microglia activation as noted by decrease in microglia numbers, soma size and reduced outward rectifier K+ current density in Hv1-/- mice compared to WT mice at 7 d following SCI. Our results therefore implicate that Hv1 may be a promising potential therapeutic target to alleviate secondary damage following SCI caused by microglia/macrophage activation.
cFos Ensembles in the Dentate Gyrus Rapidly Segregate Over Time and do not Form a Stable Map of Space
Authors: Lamothe-Molina Paul , Franzelin Andreas , Auksutat Lea , Laprell Laura , Ahlbeck Joachim , Engel Andreas , Kneussel Matthias , Morellini Fabio , Oertner Thomas 
Published: October 2020

Abstract
Mice require several days of training to master the water maze, a spatial memory task for rodents. The hippocampus plays a key role in the formation of spatial and episodic memories, a process that involves the activation of immediate-early genes such as cFos. We trained cFos-reporter mice in the water maze, expecting that consistent spatial behavior would be reflected by consistent cFos patterns across training episodes. Even after extensive training, however, different sets of dentate gyrus (DG) granule cells were activated every day. Suppressing activity in the original encoding ensemble helped mice to learn a novel platform position (reversal learning). Our results suggest that even in a constant environment, cFos+ ensembles in the dorsal DG segregate as a function of time, but become partially reactivated when animals try to access memories of past events.
Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection
Authors: Li Chengfang , Wu Xinglong , Yang Shuang , Yang Xiaorong , Yao Jin , Zheng Hong 
Published: October 2020

Abstract
BackgroundGastric adenocarcinoma of the fundic gland type (GA-FG) has been added to the 2019 edition of the World Health Organization’s list of digestive system-associated cancers. This lesion differentiates toward the fundic gland and mostly involves chief cell-predominant differentiation with low-grade cytology. Clinicians and pathologists are still unaware of this rare disease; consequently, some cases are incorrectly diagnosed. This study aimed to investigate the clinicopathological features of GA-FG using retrospective analyses of endoscopic and pathological findings. Materials and methodsSamples were collected from patients diagnosed with GA-FG. The clinical courses of all patients were monitored prospectively and reviewed retrospectively. Available clinical information, endoscopic features, pathological appearance, and follow-up data were assessed. Immunohistochemistry [mucin (MUC) 2, MUC5, MUC6, P53, CDX2, Ki67, SYN, CD56, CGA, β-catenin, and pepsinogen-I] was examined using Envision two-step method.ResultsEight cases of endoscopic submucosal dissection (ESD) were obtained from our institution. Patient age ranged from 48-80 years (mean, 65 years). Some patients were on acid-suppressing medication. Most lesions were located in the upper third (n = 7) and one was in the middle third of the stomach. Six lesions were of the superficial flat type, whereas two were of the superficial elevated type. Narrow-band imaging using magnifying endoscopy showed irregular microvascular patterns (MVPs) in four cases and regular MVPs in the remaining cases. All lesions were primarily solitary and ~6 mm in diameter (largest, 12 mm). All tumors were localized in the mucosal layer with six cases of invasion into the submucosal layer. Well-formed glands of chief cells were predominant. Tumor cells were positive for pepsinogen-I, MUC6, SYN, and CD56. Lymphatic and vascular infiltration and metastatic and recurrent disease were not observed in any case.CONCLUSIONGA-FG, a well-differentiated adenocarcinoma with mild atypia, can be completely removed using ESD, with a favorable prognosis in patients.
Odor identification in novel olfactory environments is selectively impaired in a mouse model of autism
Authors: LI Yan , Swerdloff Mitchell , She Tianyu , Rahman Asiyah , Sharma Naveen , Shah Reema , Castellano Michael , Mogel Daniel , Wu Jason , Ahmed Asim , Miguel James San , Cohn Jared , Shah Nikesh , Otazu Gonzalo 
Published: October 2020

Abstract
Aversion to novel stimuli in autism affects quality of life. We developed a behavioral paradigm to study the effect of novel background odors on odor discrimination in mouse models of autism. We trained wild type mice to discriminate target odors in known background odors. When tested, mice could discriminate known targets in novel background odors, a task similar to the visual CAPTCHA used to distinguish humans from computers. Using glomerular imaging data, we showed that WT mice used an algorithm that required less training data than a linear classifier or nearest neighbor classifier. The Cntnap2−/− mouse model of autism matched wild type mice performance in the presence of known backgrounds, but performance fell almost to chance levels in the presence of novel backgrounds. Wild-type mice use a robust algorithm for detecting odors in novel environments and this computation is selectively affected in a mouse model of autism.
Detecting Drought Regulators using Stochastic Inference in Bayesian Networks
Authors: Lahiri Aditya , Zhou Lin , He Ping , Datta Aniruddha 
Published: October 2020

Abstract
Background: Drought is a natural hazard that affects crops by inducing water stress. Water stress, induced by drought, accounts for more loss in crop yield than all the other causes combined. With the increasing frequency and intensity of droughts worldwide, it is essential to develop drought-resistant crops to ensure food security. In this paper, we model multiple drought signaling pathways in Arabidopsis using Bayesian networks to identify potential regulators of drought-responsive reporter genes. Genetically intervening at these regulators can help develop drought-resistant crops.Result: We create the Bayesian network model from the biological literature and determine its parameters from publicly available data. We conduct inference on this model using a stochastic simulation technique known as likelihood weighting to determine the best regulators of drought-responsive reporter genes. Our analysis reveals that activating MYC2 or inhibiting ATAF1 are the best single node intervention strategies to regulate the drought-responsive reporter genes. Additionally, we observe simultaneously activating MYC2 and inhibiting ATAF1 is a better strategy.Conclusion: The Bayesian network model indicated that MYC2 and ATAF1 are possible regulators of the drought response. Validation experiments showed that ATAF1 negatively regulated the drought response. Thus intervening at ATAF1 has the potential to create drought-resistant crops.