bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional characteristics and health effects of regional cuisines in China
Authors: Zhang Na , Ma Guansheng 
Published: January 2020

Abstract
Background and objectives
Cuisine is the characteristic manifestation of the regional culture of Chinese food, which was formed and developed along with the distribution of physical geography and environment, the development of productivity and economy, cultural environment, ethnic food diversity, religion, and psychological and physiological factors. With the rapid development of the economy, food industry, and catering industry, various local cuisines learn from each other and develop greatly. The health consciousness of Chinese residents has gradually increased, and the requirements for nutrition and health of cuisine have also become higher and higher. The nutritional characteristics of regional cuisines and their effects on human health are increasingly being studied by scientists. The development of cuisine is facing new opportunities and challenges. It is necessary to understand the nutrition and health characteristics of cuisine and to take measures to reform and innovate the development of cuisines. The primary purposes of this paper are to introduce the formation and development of cuisines, to analyze the nutritional characteristics and health effects of four most influential regional cuisines—Sichuan Cuisine, Jiangsu cuisine, Shandong cuisine, and Cantonese, and to propose suggestions on future reform and innovation of cuisines.

Methods
An online search with the following keywords of Chinese language and English language (cuisine OR dietary OR food) and (Chinese OR China) and (health OR diseases OR nutrition) was performed between January 1980 and September 2019. Multiple databases were used including CNKI, WanFang, PubMed, Health and Medical Collection, LWW, and OVID. The focus was on Chinese studies about cuisine, nutritional characteristics, and health but drawing on literature all over the world. Then, nutritional characteristics and health effects of regional cuisines in China in these related literatures were analyzed and summarized in this paper.

Results and conclusions
Different cuisines have their specific nutritional advantages and disadvantages. The health statuses of the residents are closely associated with the dietary structure and food composition in regional cuisines. Regional cuisines need to be reformed and innovated ceaselessly to promote national health. It is necessary to adopt a scientific cooking method, increase food consistency and variety, and develop healthy dishes. The awareness of the nutrition and health among chefs and residents should be enhanced. The safety and hygiene of the restaurants should be strengthened in order to adapt to the transformation of the dining mode and to further standardize the evaluation criterion of dish.
Circulating Tumor DNA Allows Early Treatment Monitoring in BRAF- and NRAS-Mutant Malignant Melanoma
Authors: Braune Jan , Keller Laura , Schiller Florian , Graf Erika , Rafei-Shamsabadi David , Wehrle Julius , Follo Marie , Philipp Ulrike , Hussung Saskia , Pfeifer Dietmar , Mix Michael , Duyster Justus , Fritsch Ralph , von Bubnoff Dagmar , Meiss Frank , von Bubnoff Nikolas 
Published: January 2020

PURPOSE We evaluated circulating tumor DNA (ctDNA) for detecting tumor burden in melanoma and examined whether early changes in the number of ctDNA copies predict response to treatment. PATIENTS AND METHODS We included 12 patients with stage III and 50 patients with stage IV melanoma with BRAF exon 15 or NRAS exon 3 mutations in tumor tissue. We used droplet digital polymerase chain reaction to retrospectively analyze serial plasma samples for mutation-positive ctDNA. RESULTS Matched plasma and serum samples were positive for ctDNA, lactate dehydrogenase, and S100 in 113 (45.8%), 108 (43.7%; not significant), and 58 (23.5%; P < .0001) of 247 samples from 50 patients with stage IV melanoma, and in 17 (63%), eight (29.6%; P = .014), and five (18.5%; P < .0001) of 27 samples from 12 patients with stage III melanoma. The number of mutant ctDNA copies correlated with concentrations of lactate dehydrogenase ( r = 0.50) and S100 ( r = 0.64), tumor volume ( r2 = 0.58), and tumor metabolic activity ( r2 = 0.83). Within 30 days before surgery, initiation of treatment, or change in treatment, ctDNA, LDH, and S100 were positive in 76.8%, 53.6% ( P = .01), and 46.4% ( P < .001) of patients, respectively. In patients with stage III or IV melanoma, early changes in ctDNA within 1 month after initiation of treatment correctly predicted RECIST response categories in 19 of 20 patients. Detectable ctDNA within 30 days after surgery or initiation of systemic treatment predicted inferior progression-free survival in patients with stage III disease ( P = .018). In patients with stage IV disease, 10 or more copies of ctDNA per mL at first follow-up indicated shorter progression-free survival (3.8 v 9 months; hazard ratio, 4.05; 95% CI, 1.56 to 10.53). CONCLUSION ctDNA indicated active tumor and was an adverse prognostic marker for tumor progression. Dynamic changes in ctDNA allowed prediction of response early after initiation of treatment. These data support the use of ctDNA to guide treatment in melanoma.
Cognitive Function in Children With Idiopathic Subclinical Hypothyroidism: Effects of 2 Years of Levothyroxine Therapy
Authors: Capalbo Donatella , Alfano Sara , Polizzi Miriam , Di Mase Raffaella , Improda Nicola , Esposito Andrea , Bravaccio Carmela , Salerno Mariacarolina 
Published: January 2020

Abstract

Background
Long-term consequences of mild subclinical hypothyroidism (SH) in children are still unclear, and the need for levothyroxine (L-T4) supplementation remains controversial. We designed a 2-year, case-control, prospective study of a cohort of children with SH to evaluate the effects of L-T4 therapy on neurocognitive outcome.

Methods
Thirty-four children, age 9.1 ± 2.6 years, with long-lasting, idiopathic, and mild SH, and 34 healthy matched controls, were enrolled. Twenty SH children underwent a 2-year L-T4 treatment (group A), whereas 14 refused treatment and were reevaluated after a 2-year-follow-up (group B). IQ and specific cognitive domains were evaluated in all children at study entry and after 2 years of therapy (group A) or observation (group B) in SH individuals.

Results
In SH children baseline IQ scores were normal and comparable to controls (full-scale IQ [FSIQ] 100.4 ± 11.3 vs 101.8 ± 14.2, verbal IQ [VIQ] 99.7 ± 13.7 vs 98.3 ± 14.9 and performance IQ [PIQ] 101.2 ± 10.4 vs 105 ± 10.4).
In group A, L-T4 treatment was associated with normalization of thyrotropin (6.3 ± 1.0 mIU/L at baseline vs 2.8 ± 1.4 mIU/L at 2 years, P &lt; .001). However, 2-year L-T4 therapy was not associated with a change in IQ scores (FSIQ 104.4 ± 13.8 vs 102.7 ± 11.0; VIQ 101.8 ± 14.9 vs 102.3 ± 11.9; and PIQ 106.5 ± 13.9 vs 102.7 ± 10.7) or in verbal or performance subtest scores. No significant differences were found in IQ scores after 2 years of treatment in group A compared to group B after a 2-year follow-up.

Conclusions
Our data suggest neurocognitive function in children is not impaired by persistent, mild, untreated SH and is not significantly modified by 2-year L-T4 supplementation.
Adhesion, motility and matrix-degrading gene expression changes in CSF-1-induced mouse macrophage differentiation
Authors: Murrey Michael W. , Steer James H. , Greenland Eloise L. , Proudfoot Julie M. , Joyce David A. , Pixley Fiona J. 
Published: January 2020

ABSTRACT
Migratory macrophages play critical roles in tissue development, homeostasis and disease, so it is important to understand how their migration machinery is regulated. Whole-transcriptome sequencing revealed that CSF-1-stimulated differentiation of bone marrow-derived precursors into mature macrophages is accompanied by widespread, profound changes in the expression of genes regulating adhesion, actin cytoskeletal remodeling and extracellular matrix degradation. Significantly altered expression of almost 40% of adhesion genes, 60–86% of Rho family GTPases, their regulators and effectors and over 70% of extracellular proteases occurred. The gene expression changes were mirrored by changes in macrophage adhesion associated with increases in motility and matrix-degrading capacity. IL-4 further increased motility and matrix-degrading capacity in mature macrophages, with additional changes in migration machinery gene expression. Finally, siRNA-induced reductions in the expression of the core adhesion proteins paxillin and leupaxin decreased macrophage spreading and the number of adhesions, with distinct effects on adhesion and their distribution, and on matrix degradation. Together, the datasets provide an important resource to increase our understanding of the regulation of migration in macrophages and to develop therapies targeting disease-enhancing macrophages.
A potent nuclear export mechanism imposes USP16 cytoplasmic localization during interphase
Authors: Sen Nkwe Nadine , Daou Salima , Uriarte Maxime , Gagnon Jessica , Iannantuono Nicholas Victor , Barbour Haithem , Yu Helen , Masclef Louis , Fernández Erlinda , Zamorano Cuervo Natalia , Mashtalir Nazar , Binan Loïc , Sergeev Mikhail , Bélanger François , Drobetsky Elliot , Milot Eric , Wurtele Hugo , Costantino Santiago , Affar El Bachir 
Published: January 2020

ABSTRACT
USP16 (also known as UBP-M) has emerged as a histone H2AK119 deubiquitylase (DUB) implicated in the regulation of chromatin-associated processes and cell cycle progression. Despite this, available evidence suggests that this DUB is also present in the cytoplasm. How the nucleo-cytoplasmic transport of USP16, and hence its function, is regulated has remained elusive. Here, we show that USP16 is predominantly cytoplasmic in all cell cycle phases. We identified the nuclear export signal (NES) responsible for maintaining USP16 in the cytoplasm. We found that USP16 is only transiently retained in the nucleus following mitosis and then rapidly exported from this compartment. We also defined a non-canonical nuclear localization signal (NLS) sequence that plays a minimal role in directing USP16 into the nucleus. We further established that this DUB does not accumulate in the nucleus following DNA damage. Instead, only enforced nuclear localization of USP16 abolishes DNA double-strand break (DSB) repair, possibly due to unrestrained DUB activity. Thus, in contrast to the prevailing view, our data indicate that USP16 is actively excluded from the nucleus and that this DUB might indirectly regulate DSB repair.
This article has an associated First Person interview with the first author of the paper.
Retrograde signaling mediates an adaptive survival response to endoplasmic reticulum stress in Saccharomyces cerevisiae
Authors: Hijazi Imadeddin , Knupp Jeffrey , Chang Amy 
Published: January 2020

ABSTRACT
One major cause of endoplasmic reticulum (ER) stress is homeostatic imbalance between biosynthetic protein folding and protein folding capacity. Cells utilize mechanisms such as the unfolded protein response (UPR) to cope with ER stress. Nevertheless, when ER stress is prolonged or severe, cell death may occur, accompanied by production of mitochondrial reactive oxygen species (ROS). Using a yeast model (Saccharomyces cerevisiae), we describe an innate, adaptive response to ER stress to increase select mitochondrial proteins, O2 consumption and cell survival. The mitochondrial response allows cells to resist additional ER stress. The ER stress-induced mitochondrial response is mediated by activation of retrograde (RTG) signaling to enhance anapleurotic reactions of the tricarboxylic acid cycle. Mitochondrial response to ER stress is accompanied by inactivation of the conserved TORC1 pathway, and activation of Snf1/AMPK, the conserved energy sensor and regulator of metabolism. Our results provide new insight into the role of respiration in cell survival in the face of ER stress, and should help in developing therapeutic strategies to limit cell death in disorders linked to ER stress.
This article has an associated First Person interview with the first author of the paper.
Compact fiber-optic spectroscopic design and its validation in atmospheric water vapor Raman lidar
Authors: Wang Yufeng , Jia Lisong , Li Xingxing , Fan Fulei , Di Huige , Song Yuehui , Hua Dengxin 
Published: January 2020

Spectroscopic systems with compact structure, high reliability, and high stability will push forward the application of lidar in the meteorological and environmental fields as well as space-based and space-borne lidar. Recently, we have successfully designed and verified a new robust fiber-optic spectroscopic Raman lidar for atmospheric water vapor measurements. The compact fiber-optic Raman spectroscopic design was proposed with a cascaded fiber Fabry–Perot filter and a fiber broadband filter, which features an all-fiber-connection structure and a high-spectral-resolution spectrum. These fiber-optic filters have been successfully fabricated in the visible region and matched each other in individual all-fiber Raman channels. The performance of the all-fiber spectroscopic system is measured experimentally, and it is demonstrated that the spectral output from the individual fiber Raman channel provides a bandwidth of 3–4 nm, a central wavelength of 660 nm or 606.7 nm, and an efficient rejection rate of more than

>

10

7

, and it can thus achieve the extraction of vibrational Raman scattering signals from water vapor and from nitrogen molecules in lidar returns and simultaneously reject elastic scattering signals. Furthermore, the fiber-optic spectroscopic Raman lidar was developed at Xi’an University of Technology in Xi’an, China (34.233°N, 108.911°E), and preliminary exploration was carried out for water vapor measurements. Two measurement examples are analyzed to validate the lidar performance and the retrieved water vapor mixing ratio profiles, and its comparisons with Weather Research and Forecasting (WRF) model data also verified the correctness of the lidar data. Despite the limitation of low coupling efficiency by a single-mode optical fiber, atmospheric water vapor measurements up to 700 m were achieved during nighttime under conditions of a 150 mJ laser pulse energy, a 600 mm telescope, and a 5 min integration time. The results validated the concept of all-fiber spectroscopic design and its feasibility for atmospheric water vapor measurements by Raman lidar. The compact fiber-structure characteristics and excellent optical properties provide a new solution to the new spectroscopic technique for operational applications of lidar and space-borne lidar.
High power, twin-band mid-infrared PPMgLN optical parametric oscillator pumped at 1.679  µm
Authors: Peng Yuefeng , Zhang Jianing , Wang Yong 
Published: January 2020

We report on a high-power, twin-band mid-infrared (MIR) periodically poled MgO-doped

L
i
N
b
O

3

(PPMgLN) optical parametric oscillator (OPO) pumped by a near-infrared pulsed OPO with 20 kHz of repetition rate. The pump source has a central wavelength of 1.679 µm and a linewidth of 0.12 nm. The MIR OPO can be tuned from 2.74 to 2.80 µm for signal and from 4.34 to 4.19 µm for idler through raising the oven temperature from 30°C to 200°C, respectively. Under 100°C oven temperature, the OPO yielded maximum total output power of 15.4 W (2.76 µm signal plus 4.29 µm idler) with single-pass pumping configuration. The beam quality

M
2

was measured to be

<

2.5

for signal and

<

4

for idler.
La cultura morisca y su importancia en el desarrollo de Argelia en el siglo XVII
Authors: Bara Mohammed Tayeb 
Published: January 2020

En la Argelia del siglo XVII, la agricultura tomó una nueva cara con los productos nuevos que trajeron con ellos los moriscos expulsados de España tras la Reconquista. Esos llegaron con nuevas formas de trabajar la tierra y con técnicas de riego muy útiles para una buena higiene de vida no sólo para los humanos, sino también para las plantas lo que muestra que los moriscos se aplicaron en todos los niveles de la economía urbana y suburbana. La artesanía tuvo, a su vez, un papel muy importante en las grandes urbes del Magreb central. Los artesanos moriscos dominaban las técnicas de las cerámicas finas de Al Ándalus, consideradas productos caros y apreciados. Sus piezas eran aptas para muchos usos, técnica que continuaron aplicando a su llegada a tierras del Magreb Central. Sin embargo, los moriscos destacaron más en el trabajo de la seda, actividad que siguieron desarrollando en sus nuevos destinos, hasta llegar a competir las ciudades argelinas con las españolas en este dominio. Cambiaron totalmente el sentido del comercio en Argel introduciendo nuevos hábitos de compra y venta de productos. Los moriscos se integraron de distintas maneras según las urbes donde se instalaron. En las ciudades del litoral centro magrebí y algunas del interior no muy alejadas del mar, les acogieron muy bien y adoptaron muchas de sus prácticas. Dichas prácticas perduraron y siguen presentes en la sociedad argelina actual sobre todo en ciudades como Tremecén, Mostaganem, Blida, Cherchel, Argel o Bujía.
Chrześcijańskie zasady wychowawcze w rodzinie Martin – rodziców św. Teresy z Lisieux
Authors: Ozorowski Mieczysław 
Published: January 2020

Rodzina jest pierwszą szkołą człowieczeństwa. Dotyczy to również rodziny, założonej przez świętych małżonków Ludwika i Zelię Martin, którzy doczekali się świętych dzieci, min. świętej Teresy od Dzieciątka Jezus. Niniejsze opracowanie przybliża problematykę środowiska rodzinnego, które wychowało oraz dało światu osoby uważane za przykład świętości dla wierzących. Szukaliśmy tu odpowiedzi na pytania jakie czynniki rodzinne wpłynęły na ukształtowanie się dojrzałych postaw osobowych i ich zaangażowania społecznego; jakie uniwersalne i chrześcijańskie zasady wychowawcze przyczyniły się do osiągnięcia sukcesu. Misterium życia rodzinnego odkrywamy na podstawie źródłowych przekazów pisanych, listów, pamiętników i dzienniczków. Z tych przekazów wyłania się pewien ideał życia rodzinnego, oparty na chrześcijańskich zasadach wychowawczych: wiary, pracowitości, uczciwości, autentyczności zachowania i życia, umiejętności świętowania i okazywania współczucia. Państwo Martin byli ludźmi pobożnymi i zaangażowanymi prokościelnie i prospołecznie. Ich historia życia stała się dla innych wzorem do naśladowania. Dawali oni przykład żywej wiary. Zachowywali oni wiele praktyk ascetycznych, które starali się zaszczepić swoim dzieciom. Cenili pracowitość i sumienność ale mieli dystans do dóbr materialnych, którymi potrafili się szczodrze dzielić z innymi, ukazując postawę miłości charytatywnej. Wzorzec przekazany przez małżonków Martin i ich rodzinę pozostaje w dużej części aktualny aż do dzisiaj.
Aktualność pedagogiki świętorodzinnej w procesie wychowania
Authors: Pryba Andrzej 
Published: January 2020

Artykuł podejmuje zagadnienie pedagogiki świętorodzinnej, która jest ściśle związana ze Zgromadzeniem Misjonarzy Świętej Rodziny i jego założycielem, sługą Bożym, ks. Janem Berthier MS. Stąd też artykuł przedstawia najpierw sylwetkę Założyciela Dzieła Świętej Rodziny, następnie prezentuje strategię wychowawczą i sposoby jej realizacji. W dalszej części analiz zostały ukazane aktualne, praktyczne aplikacje pedagogiki świętorodzinnej w ramach działalności Zgromadzenia Misjonarzy Świętej Rodziny w polskiej rzeczywistości.
Vom Katalog zur Suchmaschine
Authors: Weiner Jean-Pierre 
Published: January 2020

Zusammenfassung
Bibliotheken reagieren auf die bestehenden Trends in der Informationsvermittlung, indem sie auf Suchmaschinen-Technologie setzen, um die Akzeptanz ihrer Services gegenüber zukünftigen Nutzergruppen zu erhalten. Dieser Artikel zeigt, warum der Online-Katalog (OPAC) in seiner traditionellen Form längerfristig abgelöst wird und die Suchmaschine an seine Stelle tritt. Anhand eines Vergleichs der beiden Instrumente Katalog und Suchmaschine, werden die Besonderheiten und Unterschiede näher beleuchtet. Besonderes Augenmerk wird auf die Frage der Usability gelegt. Außerdem wird auf zeitgemäße UI- und UX-Designstandards im Überblick eingegangen.
Potential drug-drug interactions in hospitalized pediatric patients with respiratory disorders: a retrospective review of clinically important interactions
Authors: Hassanzad Maryam , Tashayoie Nejad Sabereh , Mahboobipour Amir Ali , Salem Farzaneh , Baniasadi Shadi 
Published: January 2020

Abstract

Background
Hospitalized pediatric patients are at an increased risk of experiencing potential drug-drug interactions (pDDIs) due to polypharmacy and the unlicensed and off-label administration of drugs. The aim of this study is to characterize clinically significant pDDIs in pediatric patients hospitalized in a tertiary respiratory center.

Methods
A retrospective analysis of medications prescribed to pediatric patients admitted to the pediatric ward (PW) and pediatric intensive care unit (PICU) of a respiratory referral center was carried out over a six-month period. The pDDIs were identified using the Lexi-Interact database and considered as clinically relevant according to the severity rating as defined in the database. Frequency, drug classes, mechanisms, clinical managements, and risk factors were recorded for these potential interactions.

Results
Eight hundred and forty-five pDDIs were identified from the analysis of 176 prescriptions. Of the total pDDIs, 10.2% in PW and 14.6% in PICU were classified as clinically significant. Anti-infective agents and central nervous system drugs were the main drug classes involved in clinically significant pDDIs as object and/or precipitant drugs. A higher number of medications [odds ratio (OR): 4.8; 95% confidence interval (CI): 2.0–11.4; p < 0.001] and the existence of a nonrespiratory disease, which led to a respiratory disorder (OR: 3.8; 95% CI: 1.40–10.4; p < 0.05), were the main risk factors associated with an increased incidence of pDDIs.

Conclusions
A high and similar risk of pDDIs exists in pediatric patients with respiratory disorders hospitalized in PW and PICU. The patients prescribed a higher number of medications and presenting respiratory symptoms induced by a nonrespiratory disease require extra care and monitoring. Pediatricians should be educated about clinically significant DDIs for highly prescribed medications in their settings in order to take preventive measures and safeguard patient safety.
Uncertain diagnoses in a children’s hospital: patient characteristics and outcomes
Authors: Sump Courtney A. , Marshall Trisha L. , Ipsaro Anna J. , Patel Shivani J. , Warner Dane C. , Brady Patrick W. , Hagedorn Philip A. 
Published: January 2020

Abstract

Background
A quality improvement initiative at our institution resulted in a new process for prospectively identifying pediatric hospital medicine (PHM) patients with uncertain diagnoses (UD). This study describes the clinical characteristics and healthcare utilization patterns of patients with UD.

Methods
This single center cross-sectional study included all PHM patients identified with UD during their admission. A structured chart review was used to abstract patient demographics, primary symptoms, discharge diagnoses, and healthcare utilization patterns, including consult service use, length of stay (LOS), escalation in care, and 30-day healthcare reutilization. Appropriate descriptive statistics were used for categorical and continuous variables.

Results
This study includes 200 PHM patients identified with UD. Gastrointestinal symptoms were the primary finding in 45% of patients with UD. Consult service use was highly variable, with a range of 0–8 consult services for individual patients. The median LOS was 1.6 days and only 5% required a rapid response team evaluation. As for reutilization, 7% of patients were readmitted within 30 days.

Conclusions
This descriptive study highlights the heterogeneity of patients with uncertain diagnoses. Ongoing work is needed to further understand the impact of UD and to optimize the care of these patients.