bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noninvasive ventilation masks with viral filters to protect health care workers from SARS-CoV-2 / Coronavirus infections
Authors: Dellweg Dominic , Haidl Peter , Kerl Jens , Koehler Dieter 
Published: April 2020

Abstract
Background:There is a shortage of masks and respirators for the protection of health care professionals during the current SARS-CoV-2 / Coronavirus pandemic. Masks for non-invasive ventilation (NIV) in combination with viral-proof filters could serve as an alternative protection measure. We wanted to determine the aerosol filtering efficacies of such devices in comparison to conventional surgical masks, N95 and FFP3 respirators.Method:Masks and respirators were mounted on a ventilated mannequin head in a test-chamber. Absorption of radioactive particles was measured compared to a non-filtered reference port.Results: Filter efficacies were 93.3 ± 1.5 % for a ResMed AcuCare NIV-mask plus filter, 71.2 ± 0.2 % for a ResMed Mirage Quattro FX NIV-mask plus filter, 89.4 ± 0.9 % for a Loewenstein JOYCEclinc FF NIV-mask plus filter, 48.4 ± 4 % for a surgical mask with rubber band, 60.5 ± 9.1 % for a surgical mask with ribbons, 56.9 ± 7.5 % for a FFP3 respirator, 64.5 % ± 5.1 for a N95 respirator. The ResMed AcuCare and the Loewenstein JOYCEclinic FF mask were more effective than any other of the tested devices (p < 0.001 and p = 0.001 respectively)Conclusion:NIV masks with viral-proof filters effectively filter respirable particles. Two tested NIV masks were more effective than the tested FFP3 and N95 respirators.
Safety of Transesophageal Echocardiography in Patients with Prior Chest or Neck Irradiation. A Retrospective Cohort Study.
Authors: Mahmoud Osama , Alsaid Amro 
Published: April 2020

Abstract
Aims: Prior chest and neck irradiation are considered relative contraindications to transesophageal echocardiography. The foundation of such a warning is theoretical and, at best anecdotal. We intended to retrospectively examine the safety of transesophageal echocardiography in this cohort.Methods and results: Utilizing the relevant International Classification of Diseases (ICD) and Current Procedural Terminology (CPT) code s, patients older than 18 years old with prior chest or neck irradiation therapy who underwent transesophageal echocardiography (TEE) at our institution in the period between 2004-2020 were identified and considered for inclusion. 31 patients, who underwent a total of 49 TEE studies, were included in the final analysis. In a 30 day follow up period following the index TEE, no significant complications occurred in any of the patients. Conclusions: In this small cohort of patients with prior chest or neck irradiation therapy, transesophageal echocardiography was carried out safely and successfully.
Effect of neoadjuvant radiotherapy on survival of non-metastatic Pancreatic Ductal Adenocarcinoma: A SEER Database Analysis
Authors: Wang Dan , Liu Chongshun , Yan Tingyu , Li Chenglong , Yang Qionghui , Xu Yang , Zhao Lilan , Pei Qian , Tan Fengbo , Güngör Cenap , Li Yuqiang 
Published: April 2020

Abstract
Background: Neoadjuvant radiotherapy has been shown to improve marginal negative resection and local control of Pancreatic Ductal Adenocarcinoma (PDAC). However, whether it improves overall survival (OS) in patients with non-metastatic PDAC remains controversial. Therefore, the purpose of this study was to analyze the benefits of only surgery, neoadjuvant radiotherapy, adjuvant radiotherapy, and surgery plus chemotherapy for OS in patients with non-metastatic PDAC. Methods: PDAC diagnosed by surgical histopathology in the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2016 was selected. Kaplan-Meier analysis was used to compare the prognosis of patients with different treatments. Cox proportional risk model was used to analyze independent predictors of OS. Results: For stage T1-3N0M0 PDAC patients, the OS of surgery plus chemotherapy (HRs = 0.896, 95%CIs, 0.827-0.970; P=0.007) were significantly better than the other three treatments. For stage T1-3N+M0 patients, adjuvant radiotherapy (HRs=0.613, 95% CIs, 0.579-0.649; P< 0.001) had significantly better OS than surgery plus chemotherapy and neoadjuvant radiotherapy. For stage T4N0M0 patients, neoadjuvant radiotherapy (HRs=0.482, 95% CIs, 0.347-0.670; P < 0.001) had significantly better OS than surgery plus chemotherapy and adjuvant radiotherapy. For stage T4N+M0 patients, neoadjuvant radiotherapy (HRs=0.338, 95% CIs, 0.215-0.532; P < 0.001) had significantly longer OS than adjuvant radiotherapy and surgery plus chemotherapy. Conclusions: For patients with non-metastatic PDAC, neoadjuvant radiotherapy, adjuvant radiotherapy and surgery plus chemotherapy were superior to only surgery in OS. For patients with stage T4 non-metastatic PDAC, neoadjuvant radiotherapy had the potential to be strongly recommended over adjuvant radiotherapy and surgery plus chemotherapy. However, neoadjuvant radiotherapy failed to benefit the survival of T1-3N0M0 stage patients, and surgery plus chemotherapy was preferred. For T1-3N+M0, neoadjuvant radiotherapy had no obvious advantage over adjuvant radiotherapy or surgery plus chemotherapy in OS, and adjuvant radiotherapy was more recommended.
Visualization analysis of the characteristics of COVID-19 clinical trial
Authors: Cai Xiaoqiong , Zheng Zengliang , Su Qianmin , Huang Jihan 
Published: April 2020

Abstract
Objectives: This article points out the characteristics and trends of COVID-19 clinical trials through data collection, translation, mining and visualization to help in clinical trial design.Method: The registered data of COVID-19 clinical trials are gathered from the Chinese Clinical Trial Registry and ClinicalTrials.gov website transformed by Python, further demonstrated by visual tools.Results: As of 24:00 on March 28, 2020, totally 732 trial registration records have been retrieved. Overall, there are 406 (55.46%) interventional studies and 271 (37.02%) observational studies. Among interventional studies, 38.93% are randomized parallel trials, 55 (13.55%) trials considered time condition for clinical recovery as the primary endpoint, and 46 (11.33%) trials through clinical parameters and laboratory index as the primary endpoint. In the selection of intervention measures, chemical or biological agents was under the responsibility of 43.60%, of which antivirals accounted for 14.53%, antimalarials accounted for 8.87%, and 98 cases (24.14%) of studies involving Traditional Chinese Medicine or Integrated Medicine. In addition, joint network analysis of antivirals to explore the combination of drugs is further conducted.Conclusions: By Mining characteristic information of topical COVID-19 clinical trial registration, this article deserves further trial design ideas for researchers to enhance the effects.
Factors associated with anxiety and depression in rheumatoid arthritis patients: a cross-sectional study
Authors: Uda Miyabi , Hashimoto Motomu , Uozumi Ryuji , Torii Mie , Fujii Takao , Tanaka Masao , Furu Moritoshi , Ito Hiromu , Terao Chikashi , Yamamoto Wataru , Sugihara Genichi , Nakagami Yukako , Mimori Tsuneyo , Nin Kazuko 
Published: April 2020

Abstract
Introduction / objectives Management of anxiety and depression in rheumatoid arthritis (RA) patients is vital. Previous studies investigating this topic are conflicting, and this topic still has not been thoroughly investigated. This study aimed to clarify the association of disease activity with anxiety and depression after controlling for physical disability, pain, and treatment. Method We conducted a cross-sectional study of RA patients from the Kyoto University Rheumatoid Arthritis Management Alliance cohort. For assessments, we used the Disease Activity Score (DAS28), Health Assessment Questionnaire Disability Index (HAQ-DI), and Hospital Anxiety Depression Scale. Depression and anxiety were defined by a Hospital Anxiety Depression Scale score ≥8. We then performed multivariable logistic regression analyses. Results Of 517 participants, 17.9% had anxiety, and 28.2% had depression. The multivariable logistic regression analyses showed patients with DAS28-based non-remission had low association with anxiety (odds ratio [OR] [95% confidence interval {CI}], 0.93 [0.48–1.78]: p = 0.82) but slight association with depression (OR [95% CI], 1.45 [0.81–2.61]: p = 0.22). However, severity of the patient’s global assessment (PtGA) on DAS28 was associated with anxiety (OR [95% CI], 1.15 [1.02–1.29]; p = 0.03) and depression (OR [95% CI], 1.21 [1.09–1.35]; p < 0.01). Additionally, HAQ-DI-based non-remission was associated with anxiety (OR [95% CI], 3.51 [1.85–6.64]; p < 0.01) and depression (OR [95% CI], 2.65 [1.56–4.50]; p < 0.01). Younger patients (OR [95% CI], 0.83 [0.68–1.01]; p = 0.07) and patients not treated with methotrexate (OR [95% CI], 0.67 [0.40–1.13]; p = 0.13) tended to suffer from anxiety. Patients using steroids had a closer association with depression than those not using them (OR [95% CI], 1.66 [1.03–2.67]; p = 0.04). Conclusions Assessment of disease activity, PtGA, and HAQ-DI are important for assessing anxiety and depression in RA patients. Attention should be paid to improving PtGA and physical function.
El inconsciente: una confrontación entre Bergson y Freud
Authors: Rodríguez Serón Alicia 
Published: April 2020

RESUMENAunque Bergson no ignoró las tesis de Freud ni el psicoanálisis, sin embargo las divergencias entre los dos pensadores respecto al inconsciente resultan, en gran medida, irreconciliables. El presente trabajo pretende mostrar que sus intereses en este ámbito fueron dispares: mientras Freud se interesó por el funcionamiento de los procesos inconscientes atendiendo a un punto de vista experimental más que especulativo, a Bergson le preocupa su existencia y naturaleza.PALABRAS CLAVEINCONSCIENTE – PSICOLOGÍA – BERGSON – FREUD ABSTRACTAlthough Bergson did not ignore Freud’s theses nor phychoanalysis, their divergencies concerning the unconcious are, to a great extent, irrenconciliable. The present article intentds to demostrate that ther interests were completely different : whereas Freud was interested in the unconcious processes from an experimental rather than a spectualtive point of view, Bergson was concerned with their existence and nature.KEYWORDSUNCONSCIOUS – PSYCHOLOGY – BEGSON – FREUD
La intuición en el pensamiento de Ortega
Authors: González-Sandoval Buedo José 
Published: April 2020

RESUMENEste artículo constituye un estudio sobre el concepto de la intuición en el pensamiento de Ortega y Gasset, referido a los tres órdenes de “cosas” en los que es requerida como forma de conocimiento: intuición sensible, intuición de valores e intuición del prójimo. Como intuición sensible se analiza la diversidad de significados presentes en su obra, así como una determinación genérica de dicho concepto, en conexión con el “yo ejecutivo”, que sirve de base para determinar los niveles en el proceso perceptivo, y los modos de relación del hombre con las “cosas”. En la intuición de valores, e intuición del prójimo, se determina que el planteamiento “superador” de Ortega es desplegado desde una inicial adscripción al pensamiento de Scheler, hasta posiciones más personales, que le llevan a proponer una problemática facultad “estimativa”, mediante la cual “asimila” la intuición de valores, o la “perspicacia”, y la “experiencia” como intuición del prójimo.PALABRAS CLAVEINTUICION – VALORES – PERCEPCION – ALTERIDADABSTRACTThe paper deals with the concept of intuition in Ortega y Gasset’s thought, where its reference to “things” reveals it as a form of cognition: sensible, intuition, value intuition and intuition of the other. In the first case, the different meanings of sensible intuition will be discussed and its very concept, as connecetd with the “yo ejecutivo”, wich is the base to determining the levels of the perception process and the ways man deals with “things”. Concerning the issues of value intuition and intuition of the other, from an initial assumption of Scheler’s thesis, Ortega moves on to advance a problematical “estimative” faculty, under wich value intuition, or “sharpeness”, and “experience” as intuition of the other are “assimilated”.KEYWORDSINTUITION – VALUES – PERCEPTION – OTHERNESS
De la condición política medieval: el paradigma político antes de la crisis
Authors: Rosales José María 
Published: April 2020

RESUMENEl trabajo presenta algunos de los rasgos básicos de la condición política moderna. Esboza así su génesis interna desde la sacralización del ámbito político hasta los inicios de la secularización en el siglo XIII. Para ilustrar ambos momentos de la filosofía política de Santo Tomás (elaborada a la luz de los textos de Aristóteles) provee una argumentación básica que, aun siendo incompleta para reconstruir este tránsito, resulta significativamente clarificadora. PALABRAS CLAVEFILOSOFIA POLITICA MEDIEVAL-HISTORIA DEL PENSAMIENTO POLITICO- SANTO TOMAS DE AQUINOABSTRACTThe paper presents some of the basic features of the medieval political condition. This, it outlines the genesis from the sacralization of the political realm to the beginnings of secularization in the XIIIth century. To illustrate both moments, Saint Thomas' political philosophy (worked out in the ight of Aristotle's thext) provdes a significant, though incomplete, argumentative basis. KEYWORDSMEDIEVAL POLITICAL PHILOSOPHY-HISTORY OF POLITICAL THOUGHT- AQUINAS
Primeras enseñanzas y reflexiones sobre la pandemia SARS-Cov-2
Authors: Chicaiza Tayupanta Jesus Onorato 
Published: April 2020

La diseminación de la pandemia nos demuestra que las fronteras, nacionalidades, razas son un artificio inútil, destinado a la repartición de las áreas de influencia de las clases dominantes en el mundo. Llama la atención el mapa geo-referencial de la diseminación hacia las grandes potencias.
La premisa de “sálvese quien pueda” es inútil para enfrentar esta crisis sanitaria en la que el ser humano es el vector directo de agente infeccioso, únicamente una mirada solidaria de arriba hacia abajo y de abajo hacia arriba para ponernos en una panorámica horizontal constituye una estrategia válida para enfrentar la pandemia.
Testigos de Jehová: un desafio transfusional medico y quirurgico
Authors: Fonseca Milton , Yugsi Cuichan Marco Vinicio 
Published: April 2020

Introducción: El rechazo de una transfusión de sangre y hemoderivados es una situación específica del derecho del paciente ante cualquier tratamiento y se sustenta en el principio de autonomía que se ejerce a través del consentimiento. Este derecho se pone a prueba cuando se rechaza un tratamiento vital, lo que puede causar contrariedad y dudas en la actuación del profesional. En este artículo se revisan los principios éticos, principios religiosos y los fundamentos médico-legales referentes al rechazo del tratamiento. Esta revisión persigue orientar la acción del médico que debe respetar los derechos del paciente y actuar con seguridad jurídica.
Objetivos: Identificar los fundamentos bíblicos de los testigos de Jehová para el rechazo a las transfusiones sanguíneas.
Analizar desde la perspectiva bioética el conflicto de hemotransfundir a un paciente Testigo de Jehová y su solución.
Material y Métodos: Se realizó una revisión sistemática de la literatura y de documentos de sociedades científicas dedicadas al estudió de la controversia sobre la aplicabilidad de la ética de transfusiones sanguíneas en testigos de Jehová, así como de revisiones sistemáticas, metaanálisis y estudios científicos de los últimos cinco años. Estrategia de búsqueda: Se realizaron búsquedas electrónicas en MEDLINE, EMBASE, LILACS localizados por medio de PubMed.
Resultados: En la búsqueda inicial se localizaron 52 estudios sobre el tema, aunque se excluyeron 32 que no fueron relevantes para el objetivo de esta revisión. Finalmente se seleccionaron 12 revisiones sistemáticas, 1 estudio original, 4 metaanálisis, y 3 revisiones bibliográficas.
Conclusiones: La formación de los médicos en métodos de ahorro de sangre y la mejor comprensión de los fundamentos religiosos del problema, así como de los aspectos éticos y el marco legal en nuestro país, pueden ayudar a mejorar la comunicación entre el médico y el paciente Testigo de Jehová, evitando que se generen situaciones conflictivas que en algunos casos suponen una demora en el tratamiento que puede repercutir negativamente en la salud del paciente.
Prognostic value of vitamin-D level in non-metastatic breast cancer patients in Saudi Arabia.
Authors: Elsamany Shereef , Elemam Omaima , Zeeneldin Ahmed , Elmorsy Soha , Khatry Ahmed , Alhuthali Faisal , Alsayed Suha 
Published: April 2020

Background
Deficiency of vitamin-D (Vit-D) was associated with poor survival outcome in several studies across different tumour types. The present study aims to assess the prevalence and prognostic value of Vit-D deficiency among breast cancer patients in a single institution in Saudi Arabia.
Methods
In this retrospective study, we screened patients who presented with non-metastatic breast cancer to King Abdullah Medical City, Saudi Arabia from June 2011 to December 2015. We checked baseline Vit-D level before starting systemic therapy in addition to other clinicopathological factors. Low Vit-D was defined as Vit-D level less than 30 ng /ml. The relations of Vit-D level (taking the median as the cutoff) with clinicopathological factors were assessed using Chi-Square test. Differences in survival outcome were compared using log rank test.
Results
We screened 340 patients with non-metastatic breast cancer. Baseline Vit-D levels were available for 189 patients. The median age was 50 years (range: 26- 86 years). Noteworthy, 169 (89.4%) of patients had Vit-D level <30 ng/ml with a median of 14.9 ng/ml (range: 4.0 - 45.0). Low Vit-D level (below the median) was significantly more common in premenopausal (p=0.011) and ER-negative patients (p=0.011). However, lymphovascular invasion (p=0.001), clinically (p=0.023) and pathologically positive axillary LNs (p=0.041) were linked with higher Vit- D level.
After a median follow up period of 58.2 months, 14 patients died and 40 relapsed. The 5-year disease-free survival (DFS) rates was 74.8%. The 5-year DFS rate in patients with higher Vit-D level above the median was 78.8% compared to 71.1% in patients with lower Vit-D level with no statistically significance difference (p= 0.22). The 5-year overall survival (OS) rate was 90.2%. Meanwhile, no difference in 5-year OS rate in patients with higher and lower Vit-D levels (90.3% and 89.7% respectively, p=0.6).
Conclusion
Low Vit-D level was prevalent among the studied breast cancer patients. Low Vit-D level was associated with ER-negative phenotype and premenopausal patients. Baseline Vit-D level was not significantly linked with survival outcome.
Витрати на охорону праці як об'єкт управлінського обліку і аналізу
Authors: Тацій І.В. 
Published: April 2020

У статті досліджено динаміку професійних захворювань і травматизму в Україні за останні роки. Обумовлена необхідність надання достовірних даних підприємствами різних форм власності для формування прозорої та об'єктивної інформації про витрати на охорону праці для вирішення проблем підвищення рівня професійної безпеки. Внесено зміни у класифікацію факторів щодо оцінки ефективності системи управління охороною праці. Запропоновано впровадження інтегрованої системи управління небезпеками і ризиками, екологічними аспектами шляхом постійного вдосконалення діяльності підприємства в області охорони навколишнього середовища, здоров'я та безпеки на виробництві.
MODEL MANAJEMEN PEMASARAN BERSAMA BERBASIS INTERNET DALAM UPAYA MENINGKATKAN SISTEM PENJUALAN PRODUK MASYARAKAT DESA DI KABUPATEN SERANG
Authors: Deviyantoro Deviyantoro , Wahyudin  , Amarul  
Published: April 2020

The research purpose was to produce a model of marketing management, the model is joint marketing management of Internet-based for village product. The results of this research are expected to overcome the deadlock village product marketing that is less extensive and often trapped by realtor marketing system. This research method used is research and development approach.The results of comparative hypotheses on marketing management model shown significant differences product sales performance effectiveness of rural communities in the district Waringin Kurung and Keramatwatu before and after implementation of the model joint marketing management based onInternet or the joint marketing management of Internet-based for village product is effective

Tujuan penelitian ini adalah menghasilkan suatu model manajemen pemasaran, hasil inovasi berupa cara pengelolaan pemasaran bersama produk unggulan desa berbasis internet. Hasil penelitian ini diharapkan dapat mengatasi kebuntuan pemasaran produk desa yang kurang luas dan sering terjebak oleh sistim makelar pemasaran. Metode penelitian ini menggunakan pendekatan penelitian dan pengembangan (research and development).Berdasarkan hasil pengamartan serta analisis data penelitian menunjukan bahwa pengujian hipotesis atas penerapan model yang dilakukan secara terbatas hanya pada 2 kecamatan menunjukkan terdapat perbedaan secara signifikan efektifitas kinerja penjualan produk masyarakat desa di kecamatan Waringin Kurung dan Kecamatan Keramatwatu sebelum dan setelah penerapan model Pemasaran bersama berbasis Internet.
Des​criptive text to the Geological map of Greenland, 1:500 000, Lambert Land, Sheet 9
Authors: Higgins Anthony K 
Published: April 2020

The Lambert Land 1:500 000 scale geological map sheet covers a segment of the East Greenland Caledonian orogen extending between latitudes 78°–81°N and longitudes 13°–29°W. The region was geologically mapped in the summers of 1978–1980 and 1993–1995 as part of a regional Survey mapping programme, and the map sheet was printed in 2000. The region covered by the Lambert Land map sheet comprises a northern segment of the East Greenland Caledonides that is in thrust contact with the Caledonian foreland. The contact is an Edipping, NNE–SSW-trending thrust that runs through Kronprins Christian Land from west of Blåsø in the south to the region east of Sjælland Fjelde in the north. The Caledonian foreland succession is exposed in Mylius-Erichsen Land and Amdrup Højland on the west side of Danmark Fjord, and in western Kronprins Christian Land on the east side of Danmark Fjord. The several kilometre thick foreland succession ranges in age from Palaeoproterozoic to Silurian. In western Kronprins Christian Land the undeformed Ordovician–Silurian carbonates of the foreland pass eastwards into the so-called Thinskinned fold-and-thrust belt developed in the same strata that farther eastwards are structurally overlain by the allochthonous Vandredalen thrust sheet. This thrust sheet is in its turn overlain by a group of thrust sheets that make up the mountainous high ground of central parts of Kronprins Christian Land, and structurally form the so-called Western thrust belt; these rock units have a deeper crustal origin. In the extreme east the Nørreland thrust sheet is exposed in a coastal strip that comprises Palaeoproterozoic crystalline gneisses that include eclogite-facies enclaves and units of meta-igneous and metasedimentary rocks.
Post-Caledonian rocks crop out in the north-eastern coastal parts of the map sheet area, and include sedimentary rocks of early Carboniferous to late Jurassic age that form part of the Wandel Sea Basin succession. Undifferentiated Quaternary deposits, ground moraine, alluvial fans and talus are distinguished where they obscure significant areas of bedrock.