bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the Load–Velocity Profile Following Power- and Strength-Oriented Resistance-Training Programs
Authors: Pérez-Castilla Alejandro , García-Ramos Amador 
Published: September 2020

Objective: To compare the short-term effect of power- and strength-oriented resistance-training programs on the individualized load–velocity profiles obtained during the squat (SQ) and bench-press (BP) exercises. Methods: Thirty physically active men (age = 23.4 [3.5] y; SQ 1-repetition maximum [1RM] = 126.5 [26.7] kg; BP 1RM = 81.6 [16.7] kg) were randomly assigned to a power- (exercises: countermovement jump and BP throw; sets per exercise: 4–6; repetitions per set: 5–6; load: 40% 1RM) or strength-training group (exercises: SQ and BP; sets per exercise: 4–6; repetitions per set: 2–8; load: 70%–90% 1RM). The training program lasted 4 wk (2 sessions/wk). The individualized load–velocity profiles (ie, velocity associated with the 30%–60%–90% 1RM) were assessed before and after training through an incremental loading test during the SQ and BP exercises. Results: The power-training group moderately increased the velocity associated with the full spectrum of % 1RM for the SQ (effect size [ES] range: 0.70 to 0.93) and with the 30% 1RM for the BP (ES: 0.67), while the strength-training group reported trivial/small changes across the load–velocity spectrum for both the SQ (ES range: 0.00 to 0.35) and BP (ES range: −0.06 to −0.33). The power-training group showed a higher increase in the mean velocity associated with all % 1RM compared with the strength-training group for both the SQ (ES range: 0.54 to 0.63) and BP (ES range: 0.25 to 0.53). Conclusions: The individualized load–velocity profile (ie, velocity associated with different % 1RM) of lower-body and upper-body exercises can be modified after a 4-wk resistance-training program.
Comparison of a Traditional Graded Exercise Protocol With a Self-Paced 1-km Test to Assess Maximal Oxygen Consumption
Authors: van den Tillaar Roland , von Heimburg Erna , Solli Guro Strøm 
Published: September 2020

Purpose: To compare the assessment of the maximal oxygen consumption (VO2max) in a traditional graded exercise test (GXT) with a 1-km self-paced running test on a nonmotorized treadmill in men and women. Methods: A total of 24 sport-science students (12 women: age 23.7 [7.7] y, body height 1.68 [0.02] m, body mass 66.6 [4.3] kg; 12 men: 22.1 [3.1] y, body height 1.82 [0.06] m, body mass 75.6 [11.0] kg) performed a traditional GXT on a motorized treadmill and a 1-km self-paced running test on a nonmotorized treadmill. VO2max, blood lactate, heart rate, and rating of perceived exertion, together with running velocity and duration at each test, were measured. Results: The main findings of the study were that the 1-km test produced significantly higher VO2max values (53.2 [9.9] vs 51.8 [8.8] mL/kg/min ) and blood lactate concentrations (11.9 [1.8] vs 11.1 [2.2] mmol/L) than the GXT (F ≥ 4.8, P ≤ .04, η2 ≥ .18). However, after controlling for sex, these differences were only present in men (60.6 [8.1] vs 58.1 [8.0] mL/kg/min , P = .027). Peak running velocity was higher in the GXT than in the 1-km test (15.7 [2.7] vs 13.0 [2.8] km/h). Men had higher VO2max values and running velocities than women in both tests. However, men and women used approximately similar pacing strategies during the 1-km test. Conclusions: Higher VO2max values were observed in a 1-km self-paced test than in the GXT. This indicates that a 1-km running test performed on a nonmotorized treadmill could serve as a simple and sport-specific alternative for the assessment of VO2max.
Experiences of Undergraduates Publishing Biomechanics Research
Authors: McErlain-Naylor Stuart A. 
Published: September 2020

The aim of this study was to investigate student experiences of publishing undergraduate research in biomechanics. A total of 29 former students with experience of publishing peer-reviewed undergraduate biomechanics research completed an online survey regarding their perceived benefits, level of involvement, and experiences in aspects of the research process. On average, students perceived their experiences to be “largely helpful” or greater in all aspects. Areas were identified corresponding to: the greatest perceived benefits (eg, understanding of the research process); the least perceived benefits (eg, statistical analysis skills); the greatest student involvement (eg, reading relevant literature); and the least student involvement (eg, developing hypotheses and/or methods). A thematic analysis of open question responses identified themes relating to: future career, skills, scientific process, intra- and interpersonal factors, and pedagogy. Common intended learning outcomes may be achieved through involvement in the research process independently of the level of staff involvement. Staff should be encouraged to involve students in publishable biomechanics research projects where this is possible without compromising research standards and should explore ways of recreating the publishing process internally for all students.
Outcomes and risk factors for ERCP-related complications in a predominantly black urban population
Authors: Kwak Nathaniel , Yeoun Daniel , Arroyo-Mercado Fray , Mubarak Ghassan , Cheung Derrick , Vignesh Shivakumar 
Published: September 2020

ObjectiveThere is a lack of literature on postendoscopic retrograde cholangiopancreatography (ERCP) complications in predominantly black urban populations of low socioeconomic status. The aim of this study was to determine the incidence and predictors of post-ERCP complications in this patient population.DesignRetrospective review of ERCP cases performed at two hospitals from 2007 to 2017 was performed. The categories of complications evaluated were overall complications, severe or fatal complications, pancreatitis, bleeding, infection, perforation and cardiopulmonary events. Predictors of complications were determined by univariate analysis.ResultsA total of 1079 ERCP procedures were reviewed. There were 106 complications (9.8%). Twenty-one were severe (1.9%) and 20 were fatal (1.9%). Both post-ERCP pancreatitis (PEP) and post-ERCP bleeding occurred in 18 patients (1.7%) each. Risk factors for overall complications were male sex (OR 1.54), ASA grade IV or V (OR 2.19), prior history of PEP (OR 6.98) and pancreatic duct stent placement (OR 2.75). Those who were ASA grade III or lower (OR 0.4) or who underwent biliary stone extraction (OR 0.62) had fewer complications. PEP was more likely in those with a prior history of PEP (OR 37.6). Those with a suspected or known biliary duct stone had less frequent pancreatitis (OR 0.32). Post-ERCP bleeding was more likely in the presence of cholangitis (OR 8.72).ConclusionOutcomes of ERCP in a predominantly black urban population demonstrate a lower incidence of PEP and all-cause mortality compared with historical data reported in the general population. Potential risk factors for post-ERCP complications were identified but require larger studies for validation.
Gastrointestinal malignancies and supportive care trials: a snapshot of the last two decades
Authors: Kouzy Ramez , Abi Jaoude Joseph , Minsky Bruce D , Das Prajnan , Koong Albert C , Subbiah Ishwaria M , Ludmir Ethan B , Taniguchi Cullen M 
Published: September 2020

BackgroundPatients with gastrointestinal (GI) cancers experience a high symptom burden due to the effects of both cancer and treatment. As such, trials assessing symptom burden and supportive interventions are crucial. Here, we characterise the landscape of phase III GI cancer clinical trials and explore study outcomes centred on the patient’s quality of life (QoL).MethodsWe searched ClinicalTrials.gov for phase III randomised controlled trials (RCTs) registered between 2000 and 2017 that are assessing a therapeutic intervention in adult patients with cancer and grouped trials by GI disease sites.ResultsOverall, we identified 76 phase III trials specific to GI cancers that enrolled a total of 53 725 patients. When analysing the primary outcomes measured, the vast majority of studies (n=71, 86%) measured disease-related endpoints such as progression-free survival or overall survival. All trials had a secondary endpoint that measured adverse events, but only 30 trials (39%) included QoL measures as secondary endpoints. Of the 30 trials that included QoL secondary endpoints, only 16 (53%) reported these results. Only five trials (7%) assessed interventions aimed at supportive measures impacting disease-related or treatment-related toxicity. None of the supportive trials included QoL as a primary endpoint and only two of these trials (40%) included QoL as a secondary endpoint.ConclusionsMost GI cancer trials failed to incorporate patient-centred outcomes or QoL measures when studying new interventions. These findings call for greater integration of patient-reported metrics, which may lead to better care and outcomes for patients with GI malignancies.
Photon induced processes: from ultraperipheral to semicentral heavy ion collisions
Authors: Schäfer Wolfgang 
Published: September 2020

AbstractWe present an overview of processes induced by the coherent Weizsäcker-Williams (WW) photon cloud in heavy ion collisions. Due to the rather broad energy spectrum of photons a large variety of physics topics can be addressed. At the low-energy side, there are the electromagnetic dissociation processes. We discuss the few-neutron production via giant dipole resonance excitation. A typical high energy photonuclear process that has attracted much attention is the diffractive photoproduction of vector mesons. We review the color dipole approach to coherent and incoherent diffractive photoproduction of$$J/\psi $$J/ψmesons. Finally we turn to peripheral and semicentral collisions and discuss the role of WW photons in the production of very low-$$P_T$$PTdileptons.
Outcomes of emergency or urgent mitral valve repair in patients with papillary muscle rupture and active infective endocarditis
Authors: Li Jun , Wang Chunsheng , Zhou Tianyu , Sun Yiping , Zhu Kai , Zhai Junyu , Sun Yongxin , Wei Lai , Lai Hao , Ding Wenjun , Hong Tao 
Published: September 2020

Background Emergency or urgent surgery is often required in patients with papillary muscle rupture and active mitral valve infective endocarditis. The aim of this study was to analyze the outcomes of patients with active endocarditis who underwent emergency or urgent mitral valve repair. Methods From 2005 to 2014, 154 ischemic mitral regurgitation patients and 41 infective endocarditis patients underwent mitral valve repair in our institution; 23 had emergency operations due to papillary muscle rupture, and 18 with active infective endocarditis underwent urgent surgery. Results Cardiopulmonary bypass time (141.4 ± 43.3 versus 145.3 ± 46.5 min) and crossclamp time (77.7 ± 34.1 versus 79.2 ± 33.0 min) were similar in the papillary muscle rupture and elective ischemic mitral regurgitation subgroups, and major postoperative complications were comparable. Hospital mortality was 17.4% in the papillary muscle rupture subgroup and 8.4% in the elective ischemic mitral regurgitation subgroup. Cardiopulmonary bypass time (103.6 ± 37.0 versus 75.5 ± 20.8 min) and crossclamp time (61.7 ± 21.2 versus 45.3 ± 18.0 min) were significantly longer in infective endocarditis patients. There were no major complications or hospital deaths. Eight years postoperatively, overall survival was 94.4% and 86.5% in the papillary muscle rupture and elective ischemic mitral regurgitation subgroups, respectively ( p = 0.730). Overall survival was 100% in both infective endocarditis subgroups. Conclusion The feasibility and effectiveness of emergency or urgent mitral valve repair in patients with papillary muscle rupture and active infective endocarditis are satisfactory. Early and mid-term outcomes are comparable to those of elective operations.
Relationship of intraoperative perfusion parameters to the need for immediate extracorporeal support following heart transplantation
Authors: Magruder J Trent , Sperry Alexandra , Atluri Pavan , Bermudez Christian , Cantu Edward , Broniec Gerald , Choi Chloe , Acker Michael A , Cevasco Marisa 
Published: September 2020

Purpose: We sought to assess the relationship of intraoperative perfusion parameters while on cardiopulmonary bypass, including oxygen delivery (DO2), to the need for ECMO following orthotopic heart transplantation (OHT). Methods: We included all adult (>18 years old) OHTs performed at our institution since implementation of an electronic perfusion record (March 2019-February 2020). Multi-organ transplants were excluded. The primary outcome was the need for immediate venoarterial ECMO in the OR following OHT. Univariable statistics were computed across demographic, clinical, operative, and perfusion variables, including oxygen delivery (DO2) measured each minute. Results: Fifty-three OHT were included with a median age of 54 years (interquartile range, 45-61). The primary outcome occurred in eight patients (15.1%). A significantly greater proportion of patients requiring ECMO had ischemic cardiomyopathy (50.0% (4/8) vs. 15.6% (7/45), p = 0.02) and had preoperative ventricular assist devices (37.5% (3/8) vs. 8.9% (4/45), p = 0.03). Median bypass times were longer in the ECMO group (217 vs. 147 minutes, p = 0.001). Phenylephrine doses were nonsignificantly higher in ECMO patients (4.1 vs. 1.9 mg, p = 0.10). No significant differences were observed in single-point median DO2 (275 vs. 294 mL O2/min/m2 BSA, p = 0.17) and nadir DO2 (226 vs. 222, p = 0.94), but increasing time and depth of DO2 below a threshold of 300 mL O2/min/m2 BSA (i.e. area over the DO2 curve (AOC) but below threshold) was significantly associated with the need for postoperative ECMO (p = 0.04). Conclusion: This is the first study to examine the relationship of perfusion parameters, including oxygen delivery, to outcomes following heart transplantation. We note that DO2 < 300-AOC was significantly associated with the need for postoperative ECMO following heart transplant. Further study will clarify whether potential DO2 differences in patients who require post-OHT ECMO reflect vasoplegia, or a more causative relationship which might be leveraged to improve outcomes.
Portal vein embolization with n-butyl-cyanoacrylate before hepatectomy: a single-center retrospective analysis of 46 consecutive patients
Authors: Moreno Berggren Marijela , Isaksson Bengt , Nyman Rickard , Ebeling Barbier Charlotte 
Published: September 2020

Background Preoperative portal vein embolization (PVE) is performed to induce hypertrophy of the future liver remnant enabling major liver resection in patients with various types of liver tumors. Purpose To evaluate safety and effectiveness of PVE with n-butyl-cyanoacrylate (NBCA). Material and Methods All consecutive patients referred to our hospital for PVE between July 2006 and July 2017 were retrospectively reviewed. Volumetry was performed on computed tomography images before and after PVE, segmenting the total liver volume and the future liver remnant (FLR), i.e. liver segments I–III. Results PVE was performed in 46 patients (18 women, 28 men; mean age = 61 years) using local anesthesia. The ipsilateral technique was used in 45 patients. Adverse events were rare. The mean FLR volume increase was 56%, the degree of hypertrophy was 9.7%, and the kinetic growth rate was 2.1%/week. The median ± SD period between PVE and liver surgery was 7 ± 3 weeks. Forty-two patients (91%) had surgery; liver resection was performed in 37 (80%) patients. Three patients (7%) developed transient liver failure after surgery. There was no 90-day post-PVE or postoperative mortality. Conclusion PVE using NBCA through the ipsilateral approach in local anesthesia is safe and effective in inducing hypertrophy of the future liver remnant enabling surgery, and thereby increasing survival in patients with liver tumors.
Measurement of iliotibial band diameter in iliotibial band friction syndrome and comparison with an asymptomatic population
Authors: Agridag Ucpinar Burcin , Bankaoglu Mujdat , Eren Osman Tugrul , Erturk Sukru Mehmet 
Published: September 2020

Background Iliotibial band friction syndrome (ITBFS) is an overuse injury of the lateral aspect of the knee. This syndrome classically affects the active young population. Purpose To determine the diameter of the ITB using magnetic resonance imaging (MRI) in patients clinically diagnosed with ITBFS, compare the results with asymptomatic patients, and assess the inter-observer agreement between a senior and a junior radiologist with different levels of experience in musculoskeletal imaging. Material and Methods From April 2014 to October 2019, 78 knee MRI scans of 78 patients were included in the study group who were referred from the orthopedic clinic with a clinical diagnosis of ITBFS. In the control group, there were 114 knee MRI scans of 114 patients who had knee MRI for various reasons and had no radiological abnormality on the performed knee MRI. The ITB diameters, cut-off values, and interclass correlation coefficient (ICC) were calculated. Results Mean thickness of the ITB was higher in the study group compared to the control group in measurements done by both the senior and junior radiologists and this was statistically significant ( P < 0.001). Cut-off values of the diameters of the ITB were calculated as 2.385 for the senior radiologist and 2.420 for the junior radiologist. ICC of 0.80 was determined, which showed excellent agreement among interpreters. Conclusion ITB thickness in the study group was significantly higher than in the control group. There was also excellent agreement among the two observers. Measurement of ITB thickness on axial plane knee MRI is one of the reliable criteria for ITBFS.
Efficacy of different treatment times of mild cerebral hypothermia on oxidative factors and neuroprotective effects in neonatal patients with moderate/severe hypoxic–ischemic encephalopathy
Authors: Yang Tingting , Li Shan 
Published: September 2020

Objective To investigate the efficacy of different treatment times of mild cerebral hypothermia for treating moderate/severe hypoxic–ischemic encephalopathy (HIE) in neonatal patients and its effects on oxidative factors. Methods This prospective, randomized, controlled study included 92 neonatal patients with moderate/severe HIE and 30 controls. The patients with HIE received routine treatment, 48 hours of hypothermia, or 72 hours of hypothermia. Results Superoxide dismutase (SOD) values were significantly lower and malondialdehyde (MDA) and neuron-specific enolase (NSE) values were higher in patients with HIE than in controls before the study. After 24, 48, and 72 hours of treatment, SOD values in all patients with HIE gradually increased and MDA and NSE values gradually decreased. At 3, 7, and 10 days, the Neonatal Behavioral Neurological Assessment scores were highest in the mild hypothermia for 72 hours group than in the other groups. The Mental and Psychomotor Development Indices scores of the Bayley Scales were significantly higher in the mild hypothermia for 72 hours group than in the other groups. Conclusion Hypothermia treatment of 72 hours is better than 48 hours for improving oxidative conditions, reducing NSE values, and improving neurological behavior and development for neonates with moderate/severe HIE.
Deferasirox, an iron-chelating agent, alleviates acute lung inflammation by inhibiting neutrophil activation and extracellular trap formation
Authors: Kono Mari , Matsuhiroya Shiori , Obuchi Ayako , Takahashi Takayuki , Imoto Shion , Kawano Seiji , Saigo Katsuyasu 
Published: September 2020

Objective Reactive oxygen species (ROS) production by neutrophils induces pulmonary endothelial cell damage and results in acute lung injury (ALI). We previously reported that deferasirox (DFS), an iron-chelating agent, inhibits the ROS production and neutrophil extracellular trap (NET) formation induced by phorbol myristate acetate and formylmethionylleucylphenylalanine in vitro. In the present study, we investigated the effects of DFS in vivo using a mouse model of lipopolysaccharide (LPS)-induced ALI. Methods After DFS administration for 7 days, ALI was induced in mice by LPS via intratracheal administration. Results LPS treatment induced neutrophil invasion in the lung tissues, along with NET formation and a significant increase in the quantity of double-stranded DNA in the bronchoalveolar lavage fluid, while pre-administered DFS inhibited these phenomena. However, alteration of neutrophil morphology in the cytoplasm in terms of shape and vacuolization was not inhibited by the pre-administration of DFS, possibly through ROS production. Conclusions DFS suppressed neutrophil invasion into lung tissues and reduced the double-stranded DNA content released by the neutrophils. These results suggest that DFS can potentially be used to prevent diseases related to neutrophil activation including ALI, thrombosis, and vascular endothelial dysfunction.
Safety and feasibility of trial of labor in pregnant women with cesarean scar diverticulum
Authors: Zheng Xiuqiong , Yan Jianying , Liu Zhaozhen , Wang Xuechun , Xu Rongli , Li Liying , Lin Zhi , Zheng Lianghui , Liu Min , Chen Yan 
Published: September 2020

Objective Literature on trial of labor after cesarean section (TOLAC) in women with isthmoceles is scarce because of complications associated with the procedure. This study investigated TOLAC's safety and feasibility in patients with isthmoceles. Methods The study group comprised 34 pregnant women with isthmoceles who vaginally delivered. The control group comprised 102 pregnant women without isthmoceles who vaginally delivered during the same period. Scar diverticula were measured using color Doppler ultrasonography; between-group delivery outcomes were compared. Results Of the study group patients, 27/34 had isthmoceles diagnosed by ultrasound before pregnancy. Nineteen (70.37%) of these patients had mild defects and eight (29.63%) had moderate defects. The scar diverticula's mean length, depth, and width were 1.05 ± 0.62, 0.54 ± 0.28, and 1.20 ± 0.70 cm, respectively. The residual muscle layer's mean thickness was 0.27 ± 0.07 cm. The mean diverticulum depth/residual muscular thickness ratio was 2.39 ± 2.58. The duration of the first stage of labor was significantly shorter and the neonatal weight was significantly lower in the study group than control group. Conclusion Successful vaginal delivery is possible for women with mild and moderate isthmoceles. Further large-scale studies are needed to improve TOLAC's safety in pregnant women with isthmoceles.
Inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats
Authors: Lin Peng , Guo Xin-xing , Wang Yi-ling , Wei Zhu-liang , Xin Hai-yan , Liu Tong-bin 
Published: September 2020

Objective This study investigated the inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats. Methods Forty-five male Wistar rats were randomly divided into three groups of 15 rats each. Fifty grams of force was used to establish an orthodontic tooth movement model. Baicalin (40 mg/kg) was locally injected into rats in the baicalin group at 3-day intervals; concurrently, normal saline was injected into rats in the negative control group. On the 21st day after orthodontic treatment, the tooth movement distance and root resorption area ratio were measured. Histomorphology changes were observed by hematoxylin and eosin staining and immunohistochemistry. Results There was no significant difference in tooth movement distance between groups. The root resorption area ratio was significantly lower in the baicalin group than in the negative control group. Runx-2 expression was significantly higher in the baicalin group than in the negative control group, while tumor necrosis factor (TNF)-α expression was significantly lower in the baicalin group than in the negative control group. Conclusions Baicalin inhibits orthodontically induced inflammatory root resorption by enhancing the expression of Runx-2 and reducing the expression of TNF-α, but does not affect tooth movement distance.