bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity, reliability and hierarchical structure of the PID‐5 among Egyptian college students: Using exploratory structural equation modelling
Authors: Aboul‐ata Mohammad , Qonsua Faten 
Published: November 2020

AbstractBackgroundThe present study aimed to investigate the pathological personality traits of undergraduate students using the Personality Inventory for DSM‐5 (PID‐5) among Egyptian university‐age participants.MethodWe replicated the five‐factor model of the PID‐5 using exploratory structural equation modelling analysis with target rotation towards the original study of the PID‐5 construction. Next, we estimated the factor congruence to identify the similarity of the present five‐factor solution with the available relevant studies. Moreover, we investigated the pattern of the Personality Pathology hierarchy for the PID‐5. The sample comprised 845 undergraduate students whose ages ranged between 18 and 28 years (mean = 19.89 and standard deviation = 1.43).ResultsThe present study findings showed that the reliability of the PID‐5 facets was acceptable. In addition, the factor congruence results showed that the replicated five factors had acceptable congruence coefficients with some relevant studies. Also, the results indicated that the hierarchy levels were found to be consistent with some relevant findings.DiscussionGenerally, the PID‐5 showed sufficient reliability and validity; however, there were significant cross‐loadings that have been discussed in detail in the succeeding text. Further, this is the first study in the Arab world that uses exploratory structural equation modelling and build a hierarchical structure to investigate the PID‐5. © 2020 John Wiley & Sons, Ltd.
Reaction mechanisms and products of lead with C6H6 and C6H5OH in incineration of sludge: A theoretical exploration
Authors: Lu Chenggang , Tang Yizhen , Tong Yi , Zhao Hui , Cheng Zhuang , Sun Jingyu 
Published: November 2020

AbstractIn this work, the reactions of Pb and PbO with benzene (C6H6) and phenol (C6H5OH) during sludge incineration were investigated using quantum chemistry methods. Result indicates that Pb reacts with two organics via insertion mechanism to form C6H5PbH, C6H5OPbH, C6H5PbOH, and m‐, o‐, p‐HPbC6H4OH. The energy barriers are modest to overcome, and all products are rather stable with their relative energy from around −130 to −250 kJ/mol; therefore, Pb could be formed as Pb‐organic compounds deposited in bottom ash or fly ash. Moreover, C6H5OPbH is the most feasible products thermodynamically and kinetically. In presence of oxygen, Pb might be oxidized to be PbO firstly, and C6H5PbOH and o‐HOPbC6H4OH were formed when PbO as reactant; the corresponding barriers are high to be 114 and 53 kJ/mol, respectively, indicating these organic‐metal compounds are difficult to generate during incineration of sludge. It implies that O2 free condition is more feasible for Pb to be deposited as compounds in bottom slag or fly ash. Thus, the secondary treatment of bottom slag or fly ash is necessary to reduce the harm of Pb‐contained compounds after sludge incineration.
Perceptions of cancer as a death sentence: Tracking trends in public perceptions from 2008 to 2017
Authors: Moser Richard P. , Arndt Jamie , Jimenez Tyler , Liu Benmei , Hesse Bradford W. 
Published: November 2020

AbstractObjectiveThere has been steady progress in reducing cancer mortality in the United States; however, this progress hasn't been evenly distributed across regions. This paper assesses trends in cancer mortality salience (CMS), that is, agreeing that getting cancer is a death sentence, over time in the United States and examines correlates of CMS.MethodsData from three administrations of the Health Information National Trends Survey (HINTS), gathered in 2008, 2013, and 2017, were merged, resulting in a total sample of 10,063 respondents. Trends in changes in CMS over time were examined as well as maps of the distribution of CMS in the United States. A logistic regression model was conducted, regressing CMS on a set of sociodemographic, psychological, health‐related, and environmental predictors.ResultsThe aggregated percentage of US adults who agreed with the CMS statement changed over time and was modified by age. Geographic distribution of agreement with CMS was inconsistent across the United States. In the adjusted logistic model, perceived health (worse health), cancer prevention, fatalism, and confusion, and cancer status (no cancer) were all significantly associated with CMS. There was also a significant interaction between survey year and age.ConclusionDespite recent information that cancer mortality rates are decreasing, most US adults still see cancer as a death sentence and this is especially an issue in certain subgroups. These findings have ramifications for groups of people who may be at risk for developing cancer given their attitudes and beliefs that there isn't much they can do to prevent or control it.
Is robot‐assisted retroperitoneal adrenalectomy safe? An investigation of perioperative hypertensive crisis among hypertensive and normotensive patients
Authors: Zhou Qiqi , Lei Enjun , Ren Haijing , Yuan Qian , Ou Yangru , Liu Wei 
Published: November 2020

AbstractBackgroundObjective: We examined the incidence of perioperative hypertensive crisis in robot‐assisted retroperitoneal laparoscopic adrenalectomy.MethodsA consecutive series of 120 patients with adrenal tumours undergoing robot‐assisted retroperitoneal laparoscopic adrenalectomy were included. Patients were divided into two groups: group A (hypertension group, 58 cases, mean age 43.59 years) and group B (normotension group, 62 cases, mean age 48.01 years). General anaesthesia was applied using endotracheal intubation and haemodynamic changes were closely monitored.ResultsA total of nine (7.5%) hypertensive crisis cases were observed. After intravenous infusion of sodium nitroprusside, seven cases of them were quickly controlled and two cases experienced transient severe hypertension. The incidence of hypertensive crisis was 13.7% and 1.6% in groups A and B, respectively (p < 0.05).ConclusionThese findings highlight the importance of strengthening the monitoring of anaesthesia and taking various measures to effectively control the blood pressure in robot‐assisted retroperitoneal laparoscopic adrenalectomy, especially among hypertensive patients.
Severe acute respiratory syndrome coronavirus‐2 natural animal reservoirs and experimental models: systematic review
Authors: Younes Salma , Younes Nadin , Shurrab Farah , Nasrallah Gheyath K. 
Published: November 2020

SummaryThe current severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) outbreak has been rapidly spreading worldwide, causing serious global concern. The role that animal hosts play in disease transmission is still understudied and researchers wish to find suitable animal models for fundamental research and drug discovery. In this systematic review, we aimed to compile and discuss all articles that describe experimental or natural infections with SARS‐CoV‐2, from the initial discovery of the virus in December 2019 through to October 2020. We systematically searched four databases (Scopus, PubMed, Science Direct and Web of Science). The following data were extracted from the included studies: type of infection (natural or experimental), age, sample numbers, dose, route of inoculation, viral replication, detection method, clinical symptoms and transmission. Fifty‐four studies were included, of which 34 were conducted on animal reservoirs (naturally or experimentally infected), and 20 involved models for testing vaccines and therapeutics. Our search revealed that Rousettus aegyptiacus (fruit bats), pangolins, felines, mink, ferrets and rabbits were all susceptible to SARS‐CoV‐2, while dogs were weakly susceptible and pigs, poultry, and tree shrews were not. In addition, virus replication in mice, mink, hamsters and ferrets resembled subclinical human infection, so these animals might serve as useful models for future studies to evaluate vaccines or antiviral agents and to study host‐pathogen interactions. Our review comprehensively summarized current evidence on SARS‐CoV‐2 infection in animals and their usefulness as models for studying vaccines and antiviral drugs. Our findings may direct future studies for vaccine development, antiviral drugs and therapeutic agents to manage SARS‐CoV‐2‐caused diseases.
Cooperative fault‐tolerant fuzzy tracking control for nonlinear multiagent systems under directed network topology via a hierarchical control scheme
Authors: Xiao Shuyi , Dong Jiuxiang 
Published: November 2020

AbstractThis article investigates the issue of cooperative fault‐tolerant fuzzy tracking control for a class of nonlinear multiagent systems subject to actuator failures and external disturbances under a directed network topology. By introducing the hierarchical control scheme, a fully distributed tracking control method is proposed. Specifically, the hierarchical control framework includes the upper layer and the lower layer. The upper layer consists of a virtual system and a virtual cooperative controller. The lower layer consists of an actual system and a fault‐tolerant tracking controller. Compared with the most existing distributed fault‐tolerant control methods where the fault in one agent may cause chain reaction, the phenomenon of fault propagation can be eliminated. Finally, the proposed strategy is demonstrated by simulation results.
Three‐stage forgetting factor stochastic gradient parameter estimation methods for a class of nonlinear systems
Authors: Ji Yan , Kang Zhen 
Published: November 2020

AbstractThis article focuses on the parameter estimation for a class of nonlinear systems, that is, multi‐input single‐output or two‐input single‐output Hammerstein finite impulse response systems with autoregressive moving average noise. The key is to investigate new estimation methods for on‐line parameter estimation of the considered system. By using the gradient search and introducing the forgetting factor, the forgetting factor stochastic gradient estimation method is developed. For the purpose of improving the parameter estimation accuracy, the system is decomposed into three subsystems with fewer variables applying the key term separation technique: the first two subsystems contain the unknown parameters related to the input and the third subsystem contains the unknown parameters related to the noise. Then a three‐stage forgetting factor stochastic gradient algorithm is proposed based on the hierarchical identification principle for interactively identifying each subsystem. The simulation results show the effectiveness of the presented algorithm.
On the Biophysical Investigation of Sulfamethazine‐Hemoglobin Binding and the Resulting Adverse Effects of Antibiotics
Authors: Ovung Aben , Mavani A. , Chatterjee Sabyasachi , Das Abhi , Suresh Kumar Gopinatha , Bhuiya Sutanwi , Das Suman , Bhattacharyya Jhimli 
Published: November 2020

AbstractBinding of the well‐known antibiotic drug sulfamethazine (SMZ) with tetrameric heme protein, hemoglobin (Hb), was studied using spectroscopic, calorimetric and molecular docking techniques. SMZ belongs to the sulfonamide group of medicines with versatile applications. Nevertheless, it can be biologically harmful if used in excess or in an uncontrolled manner. The binding induced absorbance and fluorescence data indicated a ground state complex formation between the drug and the protein with 1 : 1 stoichiometry. Drug induced conformational perturbation of Hb structure was investigated with circular dichroism and synchronous fluorescence. The binding constant obtained from spectroscopy was in the order of 104 M−1which was further confirmed by isothermal titration calorimetry. This may be higher compared to that of the oxygenation in Hb; thus SMZ binding can subsequently interrupt the oxygen transporting property of this iron protein. FRET analysis showed that the distance between SMZ and Hb is ∼3.75 nm, which is suitable for an effective binding. The MD simulation substantiated the mode and site of binding by confirming the factors contributing to the binding energy. It shows that SMZ binds to the central cavity close to subunit α 1‐helix of Hb. Residues around the drug forms hydrogen bonding and increases hydrophobicity to stabilize the SMZ−Hb complex. The binding interaction appears to be dominated by H‐bond formation and electrostatic and hydrophobic forces. This is in agreement with the thermodynamic analyses and contributes to the binding energy.
Aryl‐Aryl Cross‐Coupling with Hypervalent Iodine Reagents: Aryl Group Transfer Reactions
Authors: Ghosh Manoj Kumar , Rout Nilendri 
Published: November 2020

AbstractAryl‐aryl cross‐coupling are a unique class of C−C bond formation reaction in organic chemistry. From last few years, various synthetic methods have been developed for aryl‐aryl cross‐coupling reaction using hypervalent iodine (III) reagents as an aryl group donor. This review highlights exciting synthetic protocols that have been used for aryl‐aryl cross‐coupling reactions with hypervalent iodine reagents employing aryl group transfer reaction. The review has categorized the metal‐catalyzed and metal free aryl‐aryl cross‐coupling reactions separately using hypervalent iodine reagents. Also this review provides the mechanistic prospective involves for aryl‐group transfer reaction.
Facile Synthesis of Dihydroquinolines via Palladium Catalyzed Sequential Amination and Cyclisation of Morita‐Baylis‐Hillman Alcohols
Authors: Sruthi Pambingal Rajan , Sankar P. Uma , Saranya Thachora Venu , Anas Saithalavi 
Published: November 2020

AbstractQuinolines and its derivatives are significant class of heterocyclic compounds which are identified as the key component in many natural products and biologically important molecules. We describe herein a facile method for the synthesis of quinoline derivatives from Morita‐Baylis‐Hillman (MBH) Alcohols via Palladium Catalyzed intramolecular aryl amination followed by allylic amination pathway. The reaction between a series of MBH alcohols and amino compounds (Tosyl, aliphatic and aromatic amines) under optimized reaction conditions with Pd(PPh3)2Cl2/DPPP catalyst system, afforded the corresponding 1,2‐dihydroquinolines upto 95 % isolated yield.
Hysteresis Modulation on Van der Waals‐Based Ferroelectric Field‐Effect Transistor by Interfacial Passivation Technique and Its Application in Optic Neural Networks
Authors: Jeon Hyeok , Kim Seung‐Geun , Park June , Kim Seung‐Hwan , Park Euyjin , Kim Jiyoung , Yu Hyun‐Yong 
Published: November 2020

Abstract2D semiconductor‐based ferroelectric field effect transistors (FeFETs) have been considered as a promising artificial synaptic device for implementation of neuromorphic computing systems. However, an inevitable problem, interface traps at the 2D semiconductor/ferroelectric oxide interface, suppresses ferroelectric characteristics, and causes a critical degradation on the performance of 2D‐based FeFETs. Here, hysteresis modulation method using self‐assembly monolayer (SAM) material for interface trap passivation on 2D‐based FeFET is presented. Through effectively passivation of interface traps by SAM layer, the hysteresis of the proposed device changes from interface traps‐dependent to polarization‐dependent direction. The reduction of interface trap density is clearly confirmed through the result of calculation using the subthreshold swing of the device. Furthermore, excellent optic‐neural synaptic characteristics are successfully implemeted, including linear and symmetric potentiation and depression, and multilevel conductance. This work identifies the potential of passivation effect for 2D‐based FeFETs to accelerate the development of neuromorphic computing systems.
Injectable Liquid Crystal Formation System for Reshaping Tumor Immunosuppressive Microenvironment to Boost Antitumor Immunity: Postoperative Chemoimmunotherapy
Authors: Hu Mei , Zhang Jiao , Yu Yulin , Tu Kun , Yang Ting , Wang Yi , Hu Qian , Kong Li , Zhang Zhiping 
Published: November 2020

AbstractExploring optimal strategies to improve patient outcome postoperatively is still under challenge. Cancer immunotherapy has great potential to prevent the postoperative tumor recurrence and metastasis, which could be further strengthened by re‐education of tumor microenvironment (TME). Herein, a local and sustained drug delivery system of liquid crystal formation system (LCFS) co‐loaded with doxorubicin (DOX) and resiquimod (R848) (D/R@LCFS) is reported to confer effective chemoimmunotherapy with reduced systematic toxicity. After local administration, D/R@LCFS turns tumor into in situ vaccine via DOX‐triggered immunogenic cell death effect accompanied with immunostimulatory effect of R848. Meanwhile, combination treatment of D/R@LCFS facilitates the recruitment of effector CD8+ T cells and the polarization of myeloid‐derived suppressor cells and immunosuppressive type 2‐polarized macrophages to tumoricidal antigen‐presenting cells, favoring antigen‐specific T cell immune response and inducing more immunogenic phenotypes in tumors. The generated in situ vaccine as well as reshaped TME by D/R@LCFS elicited systematic immune response and long term immune‐memory effect in combination with immune checkpoint blockade to significantly prevent postoperative B16F10 or 4T1 tumor recurrence and metastasis. Therefore, this combination strategy of spatiotemporal TME modulation is expected to provide a clinical available option for effective postoperative chemoimmunotherapy.
Boosting Potassium Storage by Integration Advantageous of Defect Engineering and Spatial Confinement: A Case Study of Sb2Se3
Authors: Sheng Binbin , Wang Lifeng , Huang Huijuan , Yang Hai , Xu Rui , Wu Xiaojun , Yu Yan 
Published: November 2020

AbstractThe potassium ion batteries (KIBs) based on conversion/alloying reaction mechanisms show high theoretical capacity. However, their applications are hampered by the poor cyclability resulting from the inherent large volume variations and the sluggish kinetics during K+ repeated insertion/extraction process. Herein, taken Sb2Se3 as a model material, by rational design, nickel doped‐carbon coated Sb2Se3 nanorods (denoted as (Sb0.99Ni0.01)2Se3@C) are prepared through combined strategies of the conductive encapsulation and crystal structure modification. The carbon coating acts as an efficient buffer layer that maintains superior structural stability upon cycling. The introduction of Ni atoms can enhance electrical conductivity, leading to outstanding rate performance, which are confirmed by density functional theory calculation. The (Sb0.99Ni0.01)2Se3@C displays excellent reversible capacity (410 mAh g−1 at 0.1 A g−1 after 100 cycles) and unprecedented rate capability (140 mAh g−1 at 10 A g−1). Furthermore, KFeHCF//(Sb0.99Ni0.01)2Se3@C full cell exhibits a high specific capacity (408 mAh g−1 at 0.1 A g−1), superior rate capability (260 mAh g−1 at 2 A g−1). This work can open up a new avenue for the design of stable conversion/alloying‐based anodes for high energy density KIBs.
Targeted Combination of Antioxidative and Anti‐Inflammatory Therapy of Rheumatoid Arthritis using Multifunctional Dendrimer‐Entrapped Gold Nanoparticles as a Platform
Authors: Li Jin , Chen Liang , Xu Xiaoying , Fan Yu , Xue Xue , Shen Mingwu , Shi Xiangyang 
Published: November 2020

AbstractAbundant reactive oxygen species and tumor necrosis factor‐α (TNF‐α) cytokine supply of M1‐type macrophages boost rheumatoid arthritis (RA) pathological process. For efficient RA therapy, here a multifunctional nanoplatform is presented based on generation 5 (G5) poly(amidoamine) dendrimer‐entrapped gold nanoparticles (Au DENPs) to achieve co‐delivery of antioxidant alpha‐tocopheryl succinate (α‐TOS) and anti‐inflammatory anti‐TNF‐α siRNA to macrophage cells. G5 dendrimers with amine termini are sequentially functionalized with 1,3‐propane sultone (1,3‐PS), α‐TOS through a polyethylene glycol (PEG) spacer, and PEGylated folic acid (FA), and subsequently entrapped with Au NPs. The generated functional Au DENPs exhibit desired cytocompatibility, zwitterion‐rendered antifouling property, and FA‐mediated targeting specificity, enabling serum‐enhanced siRNA delivery to M1‐type macrophage cells. Meanwhile, the attached α‐TOS affords enhanced oxidation resistance of macrophage cells. In vivo investigation shows that the treatment of a collagen‐induced arthritis mouse model using α‐TOS‐modified Au DENPs/TNF‐α siRNA polyplexes can achieve excellent combination therapy effect in inflammatory cytokines downregulation of RA lesion and bone erosions. The therapeutic efficacy is also supported by 3D micro‐computed tomography analysis and TNF‐α cytokine reduction of RA lesion joints in the mRNA, protein, and histology levels. The created multifunctional nanoplatform may be employed in antioxidative and anti‐inflammatory combination therapy of RA.
Pregnant women with the complication of depression who visit the department of Oriental Medicine at a Japanese perinatal center
Authors: Isomura Mariko , Sagawa Kei , Tobe Chiharu , Suzuki Shunji 
Published: November 2020

ABSTRACTAimWomen suffering from perinatal depression often have not noticed their mental condition, they often present with unspecified somatic complaints. Therefore, we examined the presence or absence of unspecified somatic complaints and the variability in complaints in women with perinatal depression who visited the Department of Oriental Medicine (DOM) at our Japanese perinatal center.MethodsThe material reviewed consisted of the total population of Japanese women who visited our institute for a perinatal visit and underwent delivery at ≥37 weeks gestation at our institute between 2015 and 2018. We examined the DOM consultation rate, number and duration of visits to the DOM, presence or absence of unspecified somatic complaints (general malaise), and presence or absence of frequently changing complaints in the women with and without perinatal depression.ResultsThe DOM consultation rate in women with perinatal depression was significantly higher than in those without perinatal depression (odds ratio 5.02, 75% confidence interval 3.2–7.6, P < 0.01). The rate of unspecified somatic complaints and frequently changing complaints in women with perinatal depression were significantly higher than those without perinatal depression (unspecified somatic complaints: 44% vs. 10%, odds ratio 5.79, 75% confidence interval 2.6–13, P < 0.01; frequently changing complaints: 33% vs. 4%, odds ratio 12.7, 75% confidence interval 5.0–33, P < 0.01).ConclusionTo improve the recognition and management practices of perinatal depression, a standardized training will be needed on how to communicate in order to understand the mental problems in pregnant women concerning atypical symptoms of depression and unspecified somatic complaints.