bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selected highlights of the production of light (anti-)(hyper-)nuclei in ultra-relativistic heavy-ion collisions
Authors: Dönigus Benjamin 
Published: November 2020

AbstractThe production of light (anti-)nuclei and (anti-)hypernuclei in ultra-relativistic heavy-ion collisions, but also in more elementary collisions as proton–proton and proton–nucleus collisions, became recently a focus of interest. In particular, the fact that these objects are all loosely bound compared to the temperature and energies, e.g. the kinetic energies involved, is often stressed out to be special for their production. The binding energies of these (anti-)nuclei is between 130 keV ($${\mathrm {\Lambda }}$$Λseparation energy in the hypertriton) and about 8 MeV per nucleon. Whereas the connected temperatures are of the order of 100 to 160 MeV. This lead to some difficulties in the interpretation of the usually discussed production models, i.e. coalescence and statistical-thermal models, as will be discussed here. In this brief review we discuss selected highlights of the production of light (anti-)nuclei, such as (anti-)deuteron, (anti-)helium and (anti-)alpha nuclei. In addition, we will discuss the current status of the highly debated lifetime of the (anti-)hypertriton and connected measurements and model results.
Tolerance versus synaptic noise in dense associative memories
Authors: Agliari Elena , De Marzo Giordano 
Published: November 2020

AbstractThe retrieval capabilities of associative neural networks are known to be impaired by fast noise, which endows neuron behavior with some degree of stochasticity, and by slow noise, due to interference among stored memories; here, we allow for another source of noise, referred to as “synaptic noise,” which may stem from i. corrupted information provided during learning, ii. shortcomings occurring in the learning stage, or iii. flaws occurring in the storing stage, and which accordingly affects the couplings among neurons. Indeed, we prove that this kind of noise can also yield to a break-down of retrieval and, just like the slow noise, its effect can be softened by relying on density, namely by allowingp-body interactions among neurons.
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth
Authors: Wang Yong , Luo Maowu , Chen Yan , Wang Yijie , Zhang Bo , Ren Zhenhua , Bao Lei , Wang Yanan , Wang Jennifer E. , Fu Yang-Xin , Luo Weibo , Wang Yingfei 
Published: November 2020

Abstract

Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered activation of the DNA sensor cyclic guanosine monophosphate-adenosine monophosphate synthase in micronuclei, leading to further activation of the downstream signaling effectors stimulator of IFN genes and NF-κB, but not TANK-binding kinase 1 and IFN regulatory factor 3, thereby inducing the expression of IFNβ and IFN-stimulated genes (ISG) in breast cancer cells in vitro and tumors in vivo. ZMYND8 knockout (KO) in breast cancer cells promoted infiltration of CD4+ and CD8+ T cells, leading to tumor inhibition in syngeneic mouse models, which was significantly attenuated by treatment of anti-CD4/CD8–depleting antibodies or anti-IFNAR1 antibody and in immunodeficient Rag1 KO mice. In human breast tumors, ZMYND8 was negatively correlated with ISGs, CD4, CD8A, CD8B, and the tumor-lymphocyte infiltration phenotype. Collectively, these findings demonstrate that maintenance of genome stability by ZMYND8 causes breast cancer cells to evade cytotoxic T-lymphocyte surveillance, which leads to tumor growth.

Significance:
These findings show that ZMYND8 is a new negative and intrinsic regulator of the innate immune response in breast tumor cells, and ZMYND8 may be a possible target for antitumor immunotherapy.
Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Authors: Andreassen Maren M. Sjaastad , Rodríguez-Soto Ana E. , Conlin Christopher C. , Vidić Igor , Seibert Tyler M. , Wallace Anne M. , Zare Somaye , Kuperman Joshua , Abudu Boya , Ahn Grace S. , Hahn Michael , Jerome Neil P. , Østlie Agnes , Bathen Tone F. , Ojeda-Fournier Haydee , Goa Pål Erik , Rakow-Penner Rebecca , Dale Anders M. 
Published: November 2020

Abstract

Purpose:
Diffusion-weighted MRI (DW-MRI) is a contrast-free modality that has demonstrated ability to discriminate between predefined benign and malignant breast lesions. However, how well DW-MRI discriminates cancer from all other breast tissue voxels in a clinical setting is unknown. Here we explore the voxelwise ability to distinguish cancer from healthy breast tissue using signal contributions from the newly developed three-component multi-b-value DW-MRI model.

Experimental Design:
Patients with pathology-proven breast cancer from two datasets (n = 81 and n = 25) underwent multi-b-value DW-MRI. The three-component signal contributions C1 and C2 and their product, C1C2, and signal fractions F1, F2, and F1F2 were compared with the image defined on maximum b-value (DWImax), conventional apparent diffusion coefficient (ADC), and apparent diffusion kurtosis (Kapp). The ability to discriminate between cancer and healthy breast tissue was assessed by the false-positive rate given a sensitivity of 80% (FPR80) and ROC AUC.

Results:
Mean FPR80 for both datasets was 0.016 [95% confidence interval (CI), 0.008–0.024] for C1C2, 0.136 (95% CI, 0.092–0.180) for C1, 0.068 (95% CI, 0.049–0.087) for C2, 0.462 (95% CI, 0.425–0.499) for F1F2, 0.832 (95% CI, 0.797–0.868) for F1, 0.176 (95% CI, 0.150–0.203) for F2, 0.159 (95% CI, 0.114–0.204) for DWImax, 0.731 (95% CI, 0.692–0.770) for ADC, and 0.684 (95% CI, 0.660–0.709) for Kapp. Mean ROC AUC for C1C2 was 0.984 (95% CI, 0.977–0.991).

Conclusions:
The C1C2 parameter of the three-component model yields a clinically useful discrimination between cancer and healthy breast tissue, superior to other DW-MRI methods and obliviating predefining lesions. This novel DW-MRI method may serve as noncontrast alternative to standard-of-care dynamic contrast-enhanced MRI.
Cristina Antunes: extraordinária leitora e guardiã dos livros
Authors: Dias Débora 
Published: November 2020

From a house at Princesa Isabel Street to the impressive building at USP, Cristina Antunes (1951-2019) is a protagonist who follows the formation and development of a library which is constituted by many collections, from different periods of time. In this text, she is invited to remember its trajectory, in which condenses and mixes the reflection over the act of reading and the interaction of researchers and collectors with the experience of someone who have always been close to the manuscript, printed version and the libraries. A talk, based on two interviews, is also a tribute to the “cordéis” collector, paleographer, translator, library specialist, book organizer, writer, researcher and above everything, reader.
Clinical Presentation of Sustained Monomorphic Ventricular Tachycardia Without Cardiac Arrest
Authors: Havakuk Ofer , Viskin Dana , Viskin Sami , Adler Arnon , Rozenbaum Zach , Elbaz Zuzut Meital , Borohovitz Ariel , Chorin Ehud , Rosso Raphael 
Published: November 2020

Background
“Palpitations” are one of the most common complaints prompting medical attention. Textbooks of medicine and cardiology as well as guideline documents and position papers describe palpitations as a common symptom of ventricular tachycardia (VT). However, data to support this description are lacking. The aim of our study was to evaluate the symptomatology of sustained monomorphic VT with emphasis on the prevalence of palpitations.

Methods and Results

Consecutive patients presenting to our center with a first event of a regular sustained monomorphic VT (n=59) or a regular supraventricular tachycardia (SVT; n=109) between January 2012 and September 2019 were interviewed regarding their symptoms during the arrhythmic event. We included only patients with a first arrhythmic event to avoid the influence of previous medical encounters on our patients’ terminology. As expected, patients with VT were older (age 68.8±13.6 versus 52.6±16.8 years;
P
<0.001), more often of male sex (94.9% versus 37.6%;
P
<0.001), had lower left ventricular ejection fraction (37±11% versus 59±2%,
P
<0.001) and more comorbidities (87.6% versus 40.5%;
P
<0.001) compared with patients with SVT. Importantly, even though the heart rate upon presentation did not differ between the 2 groups (165±26 beats/min during VT versus 171±32 beats/min during SVT;
P
=0.16), symptomatology differed significantly; specifically, palpitations were reported in only 8.8% of VT patients, compared with 90.7% of SVT patients (
P
<0.001). Common symptoms in the VT group included chest pain (64%), dyspnea (21%), and dizziness (26%).

Conclusions
Despite similar heart rate, patients with VT rarely report having palpitations, whereas patients with SVT do so commonly. This finding may assist with decision making in patients reporting palpitations in whom an ECG tracing is not available.
A Point by Point Response to Donald Wiebe: A Manifesto for the Scientific Study of Religion
Authors: Jensen Jeppe Sinding 
Published: November 2020

Abstract
A point by point response to Wiebe’s ‘Manifesto’, mostly in support of the ‘methodological naturalism’—with added precautions on the current use of the term ‘science’. A philosophy for the study of religion is called for, with an epistemological range that caters for collective methodologies and social ontologies; respects the analytic distinction between ‘subject matter’ and ‘theoretical object’—and, ultimately, the theory-ladenness of all talk about ‘religion’. Naturalism is not about givens in the study of meaningful human behavior.
Interest and Banks in Saudi Arabia: A Dilemma
Authors: Alamer Saleh Abdulrahman 
Published: November 2020

Abstract
The banking system in Saudi Arabia faces legal issues with Sharīʿah compliance. Despite the fact that Islamic law is the main drive of the country’s legal system, Islamic banking is not well supported in the banking regulations and it may encounter legal obstacles in applying some Islamic financial mechanisms. On the other hand, conventional banking is not free of legal hurdles as it is challenged by the Islamic judiciary system in the country where interest-based loans are not enforced. These cases create a dilemma where the banking system in the country has to take a clearer legal position toward interest and Islamic banking.
Religion and Secularism in Nigeria: The Effect of Compulsory Dress Codes in the Educational System on the Right to Practice Religion
Authors: Araromi Marcus Ayodeji , Adeyemo Deborah D. 
Published: November 2020

Abstract
Though Nigeria is regarded as a secular state, there are two major religions which are predominantly practiced. Religious sentiments have permeated the societal space in Nigeria and often times the ardent practice and observance of religious tenets lead to perennial conflicts with governmental policies. It is one of the fundamental precepts of human rights that the religious belief of individuals should be respected, therefore the provision for the protection of right to religion in the national laws and some international instruments. The education system requires specific dress codes which must be observed. It is against this backdrop that this paper examines the right to practice religion in Nigeria and the obvious conflicts between this practice and policies in the Nigerian education system particularly at primary and post-primary school levels. The paper addresses the scope of the right to practice one’s religion under the law vis-à-vis governmental policies in educational institutions.
Textual Criticism, Translation Studies, and Symmachus’s Version in the Book of Job
Authors: Salvesen Alison 
Published: November 2020

Abstract
The late second century CE translator/reviser Symmachus took a very different approach to the versions of his predecessor Aquila. His renderings do not appear to have survived in Jewish circles but were much admired by early Christian scholars, thanks to their preservation in Origen’s Hexapla. However, for textual critics of the Hebrew Bible Symmachus’ free approach has limited his value since his readings cannot be easily retroverted, unlike those of Aquila or Theodotion. In the case of the book of Job, although Symmachus’ “transformations” (to use a term from Descriptive Translation Studies) differ in nature from the freedoms observed in OG Job, while rejecting the narrow isomorphism of Aquila and Theodotion he nevertheless adheres quite closely to his Hebrew Vorlage. This offers the possibility of identifying elements significant for textual criticism in his rendering, including variant reading traditions or a different consonantal text.
Multiple biomarkers measurement to estimate the duration of atrial fibrillation
Authors: Arbault-Biton Chloé , Chenevier-Gobeaux Camille , Legallois Damien , Msadek Sonia , Boubaya Marouane , Roule Vincent , Boukertouta Tanissia , Goudot Francois-Xavier , Beygui Farzin , Meune Christophe 
Published: November 2020

Background An accurate estimation of the duration of atrial fibrillation is critical for its safe management. Recent studies suggested that copeptin, carbohydrate antigen-125, galectin-3 and growth differentiation factor-15 are increased in atrial fibrillation. We examined the ability of these markers to identify patients presenting with atrial fibrillation of ≤48 versus >48 h duration. Methods Retrospective analysis of a prospective study that included patients with atrial fibrillation of known duration. Results A total of 98 patients were analysed, 47 with atrial fibrillation ≤48 h and 51 with >48 h. In patients presenting with atrial fibrillation of ≤48 versus >48 h duration, the mean carbohydrate antigen-125 concentration was 16.9 ± 12.5 versus 30.9 ± 36.3 U/mL ( P = 0.01), and growth differentiation factor-15 concentration was 1320 ± 889 versus 2608 ±2163 pg/mL ( P < 0.001). Copeptin concentration was not independently associated with atrial fibrillation duration. The galectin-3 concentration did not differ between groups. Area under the ROC curve to identify patients with atrial fibrillation ≤48 h was 0.869 for carbohydrate antigen-125, 0.853 for growth differentiation factor-15. Conclusion The plasma concentrations of carbohydrate antigen-125, growth differentiation factor-15 and copeptin, but not galectin-3, are higher in patients presenting with atrial fibrillation of >48 h duration than in those with atrial fibrillation ≤48 h. The ability to discriminate recent atrial fibrillation offered by carbohydrate antigen-125 and growth differentiation factor-15 seems high.
Pronunciation Teaching Issues: Answering Teachers’ Questions
Authors: Couper Graeme 
Published: November 2020

This article reviews questions that non-native (NNEST) and native speaker (NEST) teachers, working in different contexts, have about pronunciation teaching. It draws on theory, research, and practice to answer those questions as far as possible. The data was collected across two projects that investigated teachers’ cognitions: their knowledge, beliefs, attitudes, and practices. The first project involved semi-structured interviews with 28 NNESTs in Uruguay while the second was set in New Zealand and involved questionnaires (N=83), semistructured interviews (N=19) and classroom observations (N=6). The 19 New Zealand interviews involved 11 with New Zealand English native (L1) speakers, six with Inner Circle variety of English L1 speakers, one Outer Circle bilingual, and one Expanding Circle bilingual speaker. While a number of results from these studies have already been reported (Couper, 2016a, 2016b, 2017, 2019), this article revisits the data in order to isolate questions and issues, and compare them across the two contexts. The data from Uruguay reveal insights into NNESTs’ perspectives while the data from New Zealand provide perspectives from those teaching Asian L1 students. Questions relate to: 1. the learner; 2. what to teach; 3. how to teach; 4. dealing with curriculum, textbook, and time issues; 5. teacher’s pronunciation ability and knowledge of phonetics and phonology There are some differences between the groups, such as NNESTs lacking confidence in their own pronunciation and NESTs lacking knowledge of phonetics and phonology. However, there are more similarities, with many questions not being specific to either context. These involve pedagogic knowledge and issues around priorities, setting goals, and space for pronunciation teaching. The questions and issues are addressed in terms of theories and what is known from the increasing body of research into pronunciation teaching. Practical examples of how this knowledge can be applied in the classroom are also suggested.
Bridging the Science-to-Service Gap: Service Learning in Graduate-Level Psychology Education
Authors: Grassetti Stevie N. , Solic Katie , Getz Zachary 
Published: November 2020

Introduction: The discrepancy between what is known from clinical research and what is done in applied clinical practice is called the “science-to-service gap.” Teaching students to bridge this gap must be a primary focus of graduate education in applied psychology sub-disciplines. Statement of the Problem: Since science is fluid, an exclusive focus on teaching current empirically supported practices is insufficient. To make a meaningful impact, graduate students need opportunities to practice scientific reasoning in community settings. Literature Review: Service Learning facilitates applied experiences for students to practice scientific reasoning in “real world” settings in collaboration with community partners. Objective: In this paper, we describe the SL pedagogy and model how to apply the pedagogy to a sample graduate-level course. Teaching Implications: SL courses facilitate high impact opportunities for students to practice data-driven decision-making while serving the community. Conclusion: SL benefits students and the community. Future work can build on the model course we describe by evaluating the outcomes of SL courses against other models of effective teaching.
Pre-bypass levosimendan in ventricular dysfunction-effect on right ventricle
Authors: Kumar Dhanesh , Yadava Om Prakash , Ahlawat Vikas , Kundu Anirban , Yadav Amita , Prakash Arvind 
Published: November 2020

Background Levosimendan is an effective calcium sensitizer with complementary mechanisms of action: calcium sensitization and opening of adenosine triphosphate-dependent potassium channels, both on the sarcolemma of the smooth muscle cells in the vasculature and on the mitochondria of cardiomyocytes. Levosimendan has a long-acting metabolite with a half-life of approximately 80 h. There have been a few small studies on this drug regarding right ventricular function. In view of this, we investigated the effect of levosimendan on right ventricular function in patients with coronary artery disease. Methods This was a prospective, randomized, double-blind study on 50 patients with coronary artery disease and severe left ventricular dysfunction (left ventricular ejection fraction ≤35%) undergoing elective off-pump coronary artery bypass. Results Levosimendan had an inotropic effect on right ventricular myocardium and a vasodilatory effect on blood vessels. It caused a decline in pulmonary vascular resistance ( p < 0.018), right ventricular systolic pressure ( p < 0.001), and pulmonary artery systolic pressure ( p < 0.001), and improved right ventricular diastolic function as shown by the decrease in right ventricular Tei index ( p < 0.001), right ventricular end-diastolic pressure, and the ratio of early diastolic tricuspid inflow to tricuspid lateral annular velocity ( p < 0.006). However, we found no beneficial effects on intensive care unit or hospital stay ( p = 0.164, p = 0.349, respectively) nor a mortality benefit. Conclusions Levosimendan has salutary effects on right ventricular function in patients with severe left ventricular dysfunction undergoing coronary artery bypass, in terms of improved hemodynamic parameters.
Systematic review and meta-analysis of randomized controlled trials assessing the impact of Baduanjin exercise on cognition and memory in patients with mild cognitive impairment
Authors: Yu Liqiang , Liu Fang , Nie Pingying , Shen Cuiling , Chen Junying , Yao Liqun 
Published: November 2020

Objective: To determine the effectiveness of Baduanjin exercise in improving cognition and memory in patients with mild cognitive impairment. Data sources: Relevant English- and Chinese-language studies published until 15th September 2020 were retrieved from the PubMed, Web of Science, Cochrane Library, Embase, EBSCOhost, OVID, National Knowledge Infrastructure, WANFANG DATA, VIP Information, and SinoMed databases. Review methods: Randomized controlled trials assessing Baduanjin exercise in patients with mild cognitive impairment were included. Two researchers independently identified eligible studies and extracted data. Risk-of-bias assessment was performed using the Cochrane Risk of Bias Tool. Results: This study included 16 randomized controlled trials (1054 participants) from China that used Chinese versions of standardized tests. Most studies had no significant bias, and only one study had a high risk of bias in the random allocation category. Compared with conventional therapy alone, Baduanjin plus conventional therapy significantly improved the Montreal Cognitive Assessment and Mini-Mental State Examination scores after 6 months of treatment ( P < 0.00001 for both), significantly decreased the tau/Aβ1–42 ratio in the cerebrospinal fluid ( P < 0.00001), and significantly improved some dimensional scores on the Wechsler Memory Scale and the auditory verbal learning test scores at 6 months ( P < 0.05 for all). Conclusion: Compared with conventional therapy, Baduanjin plus conventional therapy significantly improved cognitive and memory function in patients with mild cognitive impairment.
Transabdominal approach for renal cell carcinoma with supradiaphragmatic tumor thrombus: description of a modified technique and indications for treatment
Authors: Wang Guoliang , Bi Hai , Ye Jianfei , Zhang Hongxian , Hou Xiaofei , Liu Cheng , Qiu Min , Tian Yu , Kaushik Dharam , Ma Lulin 
Published: November 2020

Objective We investigated the safety and effectiveness of a modified transabdominal approach for renal cell carcinoma (RCC) with a supradiaphragmatic inferior vena cava (IVC) tumor thrombus (TT). Methods Eight patients underwent radical nephrectomy with removal of a supradiaphragmatic IVC-TT through an abdominal incision using a transdiaphragmatic approach in Peking University Third Hospital from April 2015 to January 2018. We modified this technique using a Foley catheter balloon to avoid piggyback liver mobilization. Results All patients underwent successful operations. The median operative time was 7 hours 23 minutes. The median estimated blood loss was 2963 mL. All patients received a blood transfusion with a median blood infusion volume of 2162 mL. Two patients with Budd–Chiari syndrome developed postoperative ascites and hydrothorax due to non-watertight repair of the diaphragm. During a follow-up of 11 to 44 months, only one patient died of liver metastasis and four patients developed distant metastasis without recurrence in the IVC. Conclusions The modified transabdominal approach described herein has an encouraging safety profile and provides a surgical option for treatment of RCC with a supradiaphragmatic IVC-TT. More evidence concerning the beneficial role of this procedure will be elucidated in further studies.