bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospital‐acquired pressure ulcer incident rates among hospitals that implement an education program for staff, patients, and family caregivers inclusive of an after discharge follow‐up program in Saudi Arabia
Authors: Al Mutairi Alya , Schwebius Deborah , Al Mutair Abbas 
Published: August 2020

AbstractA tertiary public hospital in Saudi Arabia set out in 2015 to establish a team focused on reducing hospital‐acquired pressure ulcers (HAPUs). The pressure ulcer prevention program (PUPP) had a multifaceted approach and data were collected for a period of 5 years. The results showed a definite reduction in the incidences of HAPUs. Many such programs show similar positive results and echo many of the same considerations of risk, prevention strategies, and the need for early intervention. However, none of the other studies either replicate the hospital's PUPP nor the extent of the positive and lasting effect of the program. Eager to determine the contributing factor(s) in order that the project success could be continued and possibly replicated in other quality improvement projects, it was decided that an examination and comparison of other similar programs and their results would be necessary in order to uncover the answer. It was determined that the in‐person in‐home discharge follow‐up portion of the program most likely had the largest effect on the outcomes. Outcomes that were supported by the pre‐work completed during the hospital portion of the PUPP towards reducing HAPUs and readmissions.
Rate‐dependent pacing failure after pacemaker implantation: Novel insights into the mechanism of using adenosine
Authors: Ohe Hisaharu , Oginosawa Yasushi , Yamagishi Yasunobu , Miyamoto Taro , Tsukahara Keita , Kohno Ritsuko , Abe Haruhiko , Otsuji Yutaka 
Published: August 2020

AbstractAn 82‐year‐old woman received pacemaker implantation for sick sinus syndrome. Two days after the implantation, electrocardiography showed 2:1 atrial pacing failure, followed by a bradycardia‐dependent increase in the atrial pacing threshold during a pacemaker examination. However, transient 1:1 atrial pacing capture recovered by adenosine triphosphate (ATP) administration, which was performed to evaluate the bradycardia‐dependent pacing failure mechanism. We considered this phenomenon to be caused by Phase 4 depolarization and avoided replacing this atrial lead. Three weeks later, the atrial pacing threshold had improved. We report the potential role of Phase 4 depolarization in a bradycardia‐dependent increase in pacing threshold by using ATP.
Prospective evaluation of the utility of magnetic resonance imaging in patients with non‐MRI‐conditional pacemakers and defibrillators
Authors: Padmanabhan Deepak , Kella Danesh , Isath Ameesh , Tandon Nidhi , Mulpuru Siva , Deshmukh Abhishek , Kapa Suraj , Mehta Ramila , Dalzell Connie , Olson Nora , Felmlee Joel , Jondal Mary L. , Asirvatham Samuel J. , Watson Robert E. , Cha Yong M. , Friedman Paul 
Published: August 2020

AbstractBackgroundMagnetic resonance imaging (MRI) in patients with legacy cardiovascular implantable electronic devices (CIEDs) in situ is likely underutilized. We hypothesized the clinical benefit of MRI would outweigh the risks in legacy CIED patients.MethodsThis is a single‐center retrospective study that evaluated and classified the utility of MRI using a prospectively maintained database. The outcomes were classified as aiding in diagnosis, treatment, or both for the patients attributable to the MRI. We then assessed the incidence of adverse effects (AE) when the MRI was performed.ResultsIn 668, MRIs performed on 479 patients, only 13 (1.9%) MRIs did not aid in the diagnosis or treatment of the patient. Power‐on reset events without clinical sequelae in three scans (0.45%) were the only AE. The probability of an adverse event happening without any benefit from the MRI scan was 1.1 × 10−4. A maximum benefit in diagnosis using MRI was obtained in ruling out space‐occupying lesions (121/185 scans, 65.4%). Scans performed in patients for elucidating answers to queries in treatment were most frequently done for disease staging at long term follow‐up (167/470 scans, 35.5%). Conservative treatment (184/470 scans, 39%) followed by medication changes (153/470 scans, 28.7%) were the most common treatment decisions made.ConclusionsThe utility of MRI in patients with non‐MRI‐conditional CIEDs far outweighs the risk of adverse events when imaging is done in the context of a multidisciplinary program that oversees patient safety.
Honokiol ameliorates angiotensin II‐induced hypertension and endothelial dysfunction by inhibiting HDAC6‐mediated cystathionine γ‐lyase degradation
Authors: Chi Zhexi , Le Truc Phan Hoang , Lee Sang Ki , Guo Erling , Kim Dongsoo , Lee Sanha , Seo Seung‐Yong , Lee Sook Young , Kim Jae Hyung , Lee Sang Yoon 
Published: August 2020

AbstractHypertension and endothelial dysfunction are associated with various cardiovascular diseases. Hydrogen sulphide (H2S) produced by cystathionine γ‐lyase (CSE) promotes vascular relaxation and lowers hypertension. Honokiol (HNK), a natural compound in the Magnolia plant, has been shown to retain multifunctional properties such as anti‐oxidative and anti‐inflammatory activities. However, a potential role of HNK in regulating CSE and hypertension remains largely unknown. Here, we aimed to demonstrate that HNK co‐treatment attenuated the vasoconstriction, hypertension and H2S reduction caused by angiotensin II (AngII), a well‐established inducer of hypertension. We previously found that histone deacetylase 6 (HDAC6) mediates AngII‐induced deacetylation of CSE, which facilitates its ubiquitination and proteasomal degradation. Our current results indicated that HNK increased endothelial CSE protein levels by enhancing its stability in a sirtuin‐3‐independent manner. Notably, HNK could increase CSE acetylation levels by inhibiting HDAC6 catalytic activity, thereby blocking the AngII‐induced degradative ubiquitination of CSE. CSE acetylation and ubiquitination occurred mainly on the lysine 73 (K73) residue. Conversely, its mutant (K73R) was resistant to both acetylation and ubiquitination, exhibiting higher protein stability than that of wild‐type CSE. Collectively, our findings suggested that HNK treatment protects CSE against HDAC6‐mediated degradation and may constitute an alternative for preventing endothelial dysfunction and hypertensive disorders.
There is no ‘I’ in team: Career concerns, risk‐taking incentives, and team outcomes
Authors: Ngo Phong T. H. , Roberts Steven 
Published: August 2020

AbstractThe National Basketball Association contracting rules provide plausibly exogenous variation in career concerns near contract end. We use this setting to study how individual career concerns affect risk‐taking behavior and can sabotage team performance. Using the frequency and duration of player injuries from 1991 to 2013 we measure individual risk‐taking behavior. We find that the average player's likelihood of missing a game due to injury falls by 0.06 percentage points (or over 100% relative to the mean injury rate) in the final 3 months of his contract, and when missing games due to injury is unavoidable, his recovery time drops by 22 days. However, “elite” players with virtually no career concerns actually miss more games due to injury. Finally, we find that elite players missing too many games and “average” players playing before healthy, combine to hurt team performance. For each additional player in the last 3 months on contract, the win probability for that team falls by over 2.6%.
The High Prevalence of Skin Diseases in Adults Aged 70 and Older
Authors: Sinikumpu Suvi‐Päivikki , Jokelainen Jari , Haarala Anna K. , Keränen Maija‐Helena , Keinänen‐Kiukaanniemi Sirkka , Huilaja Laura 
Published: August 2020

BACKGROUND/OBJECTIVESTo determine the prevalence of skin findings and skin diseases in adults aged 70 and older, and to study the association between cutaneous diseases and socioeconomic status (SES), sex, and living status in the older population.DESIGNCross‐sectional study of Finnish adults aged 70 to 93 as part of the Northern Finland Birth Cohort 1966 Study.SETTINGSSkin examination data were available for 552 adults.MEASUREMENTSA whole‐body skin examination was performed by dermatologists. The associations between skin diseases and SES, sex, and living status were analyzed.RESULTSNearly 80% of the adults had at least one skin disease that required further treatment or follow‐up. More than one‐third of the study cases (39.1%) had three or more simultaneous skin diseases. Skin diseases were more common in men than in women (P < .001). The most common skin diseases were tinea pedis (48.6%), onychomycosis (29.9%), rosacea (25.6%), actinic keratosis (22.3%), and asteatotic eczema (20.8%). Some association was found between skin diseases and SES and living status.CONCLUSIONA whole‐body clinical skin examination is important because it reveals important diagnoses.
Relationship between hand hygiene and cutaneous findings during COVID‐19 pandemic
Authors: Altunisik Toplu Sibel , Altunisik Nihal , Turkmen Dursun , Ersoy Yasemin 
Published: August 2020

AbstractBackgroundIn the current situation of the COVID‐19 pandemic, healthcare workers (HCWs) have to comply with hygiene conditions and use gloves more frequently and for a longer period of time than they would previously to avoid infection and prevent transmission.AimsWe aimed to characterize the adverse skin reactions occurring after hand hygiene and glove use in HCWs in a tertiary university hospital to determine the possible causative factors and whether the use of these measures is affected.MethodsBetween April 15 and May 1, 2020, a cross‐sectional survey was conducted, using online questionnaire, answered by HCWs in a tertiary university hospital.ResultsThe increase in general hand‐skin problems during the pandemic period was statistically significant (P = .004). The most common symptom was dryness. During the pandemic period, 67 (24.3%) HCWs thought that the conditions were caused by glove use, and 197 (71.4%) thought that they were due to alcohol‐based hand antiseptics. The incidence of other hand‐skin conditions except for vesicles was statistically higher in women than in men (P < .001).ConclusionsIncreased number of hand‐skin conditions during the pandemic should not be ignored, since hand hygiene and glove use are expected to increase.
Combined therapy with Endoret‐Gel and plasma rich in growth factors vs Endoret‐Gel alone in the management of facial rejuvenation: A comparative study
Authors: Navarro Roge , Pino Ander , Martínez‐Andrés Asunción , Garrigós Eva , Sánchez M. Leticia , Gallego Estefanía , Anitua Eduardo 
Published: August 2020

AbstractBackgroundSkin suffers progressive decrement. An endogenous regenerative technology has been developed that has the versatility to provide an autologous injectable gel (Endoret‐Gel) or a liquid plasma rich in growth factors (PRGF) based on the patient´s own platelet‐rich plasma.AimsTo compare the efficacy of the combined therapy with Endoret‐Gel and PRGF versus Endoret‐Gel alone in the management of facial rejuvenation.MethodsTwenty clinically diagnosed patients with aged skin received either Endoret‐Gel monotherapy or Endoret‐Gel + PRGF combined therapy. Patients underwent three sessions at one‐month intervals and were clinically assessed for six months. Corneometry, sebumetry, and high‐resolution topographic analysis were carried out. Patient self‐assessment questionnaires and clinical improvement scores were also performed.ResultsThe combined therapy showed to promote a higher hydration index. These results were also significant for spot improvement at three months, while conversely, monotherapy with Endoret‐Gel demonstrated higher UV spot improvement. A significant decrease of sebum production and wrinkle development was observed for both treatment groups. Red areas also improved in a similar way at the end of the follow‐up period. After Endoret‐Gel or Endoret‐Gel + PRGF therapy, 30% and 70% of patients referred to be very satisfied, respectively. Accordingly, 40% and 80% showed a “very improved” esthetic performance. None of the patients reported a negative change and no adverse events were recorded.ConclusionBoth Endoret‐Gel monotherapy and the combined treatment with PRGF were shown to promote facial rejuvenation and to palliate the age‐related cutaneous atrophy. The combined therapy may exert a synergistic effect that addresses both skin quality improvement and soft tissue restoration in a shorter period.
Perspectives about dignity during acute care for older people and their relatives: A qualitative study
Authors: Kerr Debra , Crone Rosie , Dunning Trisha 
Published: August 2020

AbstractAims and objectivesThe aim of the study was to enhance understanding about dignified care from older peoples' and their carers' perspectives. The information will contribute to the development of a tool to measure older peoples’ dignity during hospitalisation.BackgroundOlder people are a vulnerable cohort at risk of loss of dignity during acute hospitalisation arising from environmental, behavioural and patient factors. It is not clear how older people and their relatives define dignified care in acute care settings.DesignAn interpretative descriptive method was used.MethodsA purposive sample of older people (at least 65 years) who had been hospitalised in acute care and subsequently transferred to sub‐acute care, and their relatives, were invited to participate. The study was undertaken in one sub‐acute ward in a regional healthcare organisation in Victoria, Australia. Individual interviews were audio‐recorded then transcribed. Data were analysed using thematic content analysis. The COREQ checklist was used to document reporting of the study.ResultsIndividual interviews were conducted: 24 patients and 12 relatives. Three main themes were identified: “Involve me in decisions about my care and treatment,” “Keep me safe when I am vulnerable” and “Treat me as an individual and with respect.” Older people want to be involved in decisions about their care and treatment and to receive adequate, suitable information. They feel vulnerable during hospitalisation and want to feel safe when speaking up about concerns. Individual acknowledgement is an important aspect of dignity.ConclusionsOlder people and their relatives identified specific elements of care that uphold or threaten dignity during acute hospitalisation. Nurses play a major role in upholding dignity for older people in hospital.Relevance to clinical practiceClinicians may benefit from systematic dignity‐related training. Specific strategies to enhance older persons’ dignity, including communication skills training and continence management need to be developed, implemented and evaluated.
Exploring the barriers and gateways to intersubjectivity in dementia care: A meta‐ethnography
Authors: Hodge Gary , Froggatt Katherine , Limmer Mark , Bingley Amanda 
Published: August 2020

AbstractBackgroundBehaviours that challenge in dementia, often described and diagnosed as behavioural psychological symptoms of dementia, are experienced by 75% of people living with dementia in care homes or hospital environments, with 43% of nurses and care providers reporting these behaviours as moderately or severely distressing to them. During behaviours that challenge moments in dementia, there is the potential for an intersubjective relationship to take place between the people living with dementia and the nurse.AimsThis review explores and synthesises literature to consider the presence of intersubjectivity in people living with dementia. If the ability to be intersubjective remains present for people living with dementia, it will consider how its presence can be nurtured to offer a positive intersubjective communication between the person living with dementia and their carer/nurse.MethodsThe review used meta‐ethnography methodology to develop concepts that help us to understand the implications of existing research on the presence of intersubjectivity in people living with dementia, and its relationship to those providing their care. Sixteen electronic databases (including MEDLINE/PubMed, Wiley Online Library and Sage publications) and grey literature such as Alzheimer's Society and Department of Health across journals dating from 2000–2020 were searched. Eight studies were selected and reviewed for quality and relevance for a meta‐ethnographic literature synthesis of intersubjectivity in dementia.ConclusionThe meta‐ethnography concluded that people living with dementia continue to have the capacity to be intersubjective on an emotional level. Nurses and other care providers need to acknowledge the presence of “personhood” and “personness” in people living with dementia to nurture positive intersubjective care relationships.The meta‐ethnography has also been reviewed for reporting clarity against the EQUATOR checklist in the form of the eMERGe guideline (France et al., 2019).
Providing dementia care using technological solutions: An exploration of caregivers' and dementia coordinators' experiences
Authors: Kristiansen Susanne , Beck Malene , Kabir Zarina Nahar , Konradsen Hanne 
Published: August 2020

AbstractAim and objectivesTo explore the experiences of caregivers of persons with dementia and dementia coordinators regarding their collaboration in care for a person with dementia and the feasibility of using technology in this collaboration.BackgroundCaregivers of persons with dementia have a significant risk of developing physical strain and psychological stress due to caregiver burden. Internationally, the use of technology is rapidly evolving in health care. Dementia coordinators employed in municipalities in Denmark support caregivers of persons with dementia, thus helping management of life with dementia. The cooperation between dementia coordinators and caregivers is essential, and the use of technology in everyday life is inevitable.MethodsA qualitative, exploratory, descriptive design was used. Data were derived from five focus group interviews in which 13 caregivers and 14 dementia coordinators participated. The participants' narratives were used to elucidate their experiences and attitudes, and data were analysed using thematic analysis. The study reports according to the COREQ checklist.ResultsThe analysis revealed three themes: the need for creating a safety net in everyday life, the need for moving together in the right direction and the need for handling technology while preserving relational interaction.ConclusionsTechnology might be used as a mediator to help ease some caregiving tasks or the burden of caregiving. However, technology is an area in which the caregivers must rely on their competences and initiatives. Even though the collaboration between caregivers and dementia coordinators was beneficial and supportive, dementia coordinators experienced technology as outside the core elements of their daily work.Relevance to clinical practiceWe suggest further discussion regarding who is best suited to support caregivers in making choices regarding which technologies to implement in caring for a person with dementia. If this discussion is not taken seriously, there is a risk of leaving caregivers in a technological quagmire.
Use of an audit with feedback implementation strategy to promote medication error reporting by nurses
Authors: Hutchinson Alison M. , Brotto Vanessa , Chapman Anna , Sales Anne E. , Mohebbi Mohammadreza , Bucknall Tracey K. 
Published: August 2020

AbstractAims and objectivesTo outline the development and effect of an audit with feedback implementation strategy that intended to increase the rate of voluntary medication error reporting by nurses.BackgroundMedication errors are a serious global health issue. Audit with feedback is a widely used implementation strategy that has potential to modify nurses’ reporting behaviour and improve medication error reporting rates.DesignQuasi‐experimental implementation study (fulfilling the TIDieR checklist) with two pairs of matched wards at a private hospital in Australia was conducted from March 2015–September 2016. One ward from each pair was randomised to either the intervention or control group.MethodNurses within intervention wards received audit with feedback on a quarterly basis over a 12‐month implementation period. Control wards underwent quarterly audits only (without feedback). Feedback consisted of a one‐page infographic poster, with content based on medication error data obtained from audits and the hospitals’ risk management system (RiskMan). The primary outcome—rate of medication errors reported per month—was determined in both groups at pre‐implementation, implementation and postimplementation phases. Differences between groups were compared using generalised linear mixed models with Poisson distribution and log link.ResultsA nonsignificant intervention effect was found for rate of medication errors reported per month. Interestingly, when combining data from both groups, a significant increasing time trend was observed for medication errors reported per month across pre‐implementation and implementation phases (80% increase).ConclusionsThe audit with feedback strategy developed in the present study did not effectively influence the voluntary reporting of medication errors by nurses.Relevance to clinical practiceDespite the lack of intervention effects, the use of a published checklist to optimise the reporting quality of this study will contribute to the field by furthering the understanding of how to enhance audit with feedback implementation strategies for nurses.
Web‐based educational programme for temporomandibular joint assessment with cone‐beam computed tomography
Authors: Iskanderani Durer , Alstergren Per , Ekberg Ewa Carin , Shi Xie‐Qi , Hellén‐Halme Kristina 
Published: August 2020

AbstractObjectivesTo develop and evaluate an educational web‐based programme for temporomandibular joint (TMJ) assessment using cone‐beam computed tomography (CBCT).MethodsA web‐based educational programme was designed for TMJ assessment using CBCT images. Fifteen CBCT cases of the TMJ (three‐dimensional reconstructed volumes) and an assessment module based on image analysis criteria in the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) were added to the programme. Thirty‐six undergraduate dental students were invited to test the programme by assessing all cases twice: before and after 2 months of training. Participants submitted written subjective evaluations of the programme.ResultsThe web‐based programme can be accessed on Malmö University webpage (www.cbct‐tmj.mau.se). Despite limited CBCT learning in their undergraduate training and not using the programme in the 2‐month interval, the students were able to correctly diagnose 80% of the cases at the second assessment. Their diagnoses, however, did not differ significantly from the first assessment. Overall, the students were satisfied with the programme and considered it user‐friendly.ConclusionThe web‐based educational programme that was developed in the present study and tested by dental students could be a useful educational tool for TMJ assessment using CBCT.