bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathomorphological Characteristics of Septic Shock in Modern Therapy
Authors: Chirskii V. S. , Andreeva E. A. , Yuzvinkevich A. K. , Gaivoronskii I. V. 
Published: April 2020

The aim of this studywas to identify the morphological features of organ damage due to shock in deceased with different types of sepsis under modern complex therapy.Material and methods.We studied archival material of 93 autopsies of the deceased with a clinical diagnosis of sepsis. Microscopic examination assessed the frequency among the observed groups and the prevalence of signs of damage to the microvasculature vessels, as well as organ parenchyma: myocardium, liver, kidneys, and brain. Statistical processing of the obtained data was carried out with the determination of significant differences between the observed groups.Results.4 observation groups were distinguished: the first group with leukocyte mini-foci and shock (n=10), the second group with mini-foci without shock (n=11), the third group without purulent metastases with shock (n=15), the fourth group without purulent metastases without shock (n=43). It was revealed that the main etiological factor of septic shock is gram-negative microflora. It was found that in septic shock, the activation of the coagulation system is more pronounced, which is confirmed by the greater frequency of detection of blood clots in the lumen of microvasculature blood vessels. In the deceased groups with shock and leukocyte mini-foci leukostasis in the kidney vessels and desquamation of the endothelium were detected reliably (p = 0.01 and p = 0.01) more often than in the group with shock without purulent metastases.Conclusion.Septic shock is detected in every fourth (26%) deceased with this pathology. Septic shock development is based on the hyperergic response of the body to a generalized gram-negative infection, in 64% of cases presented by Klebsiella pneumonia. Septic shock is characterized by decrease in arteriole tone, absence or minimal manifestations of purulent metastasis , more severe damage to the vessels of the microcirculatory bed, manifested through the widespread exfoliation of endotheliocytes in the lumen of the vessels, frequent development of a sludge phenomenon and blood clots in the vessels of the myocardium, as well as hyaline membranes in the lungs. The detection of at least minimal manifestations of purulent metastasis in the tissues of those who died from septic shock is associated with increased expression of adhesive molecules in the myocardial vascular endothelium, its desquamation, and the appearance of leukostasis in the kidneys. These few morphological differences are associated with the nature of the patient's body reaction to a generalized infection and, accordingly, the rate of its development.
Muscular Component of the Body in Girls: Constitutional and Individual Features
Authors: Esaulenko I. E. , Alexeeva N. T. , Karpova A. V. , Rozhkova E. A. , Klochkova S. V. , Nikityuk D. B. 
Published: April 2020

The aim of the study was to investigate the content of the muscular component of the body in girls, aged 16–20, with different somatotypes.Material and methods. The study included 500 females, aged 16–20, representatives of the Slavic ethnic group, residents of Moscow and the Moscow region. They were divided into two groups: 16–17 and 18–20 years old (250 girls in each group). The diameter of the wrist and ankle, wrist and calf circumferences (mm), thickness of the dermal-fat fold of the back, shoulder, abdomen and thigh (using a calipometry method) were calculated in girls of all groups. The content of the muscular component of the soma was also calculated by bioimpedansometry (using a Russian device "ABC-01 Медасс"). Statistical processing of findings included calculation of their arithmetic mean values, errors. The significance of differences was determined using parametric and nonparametric criteria (Student and Fisher criteria) depending on the type of distribution in the sample.Results. Heterogeneity of the population was revealed when determining a somatotype: inclusion into a particular constitutional group insignificantly modifies with the transition from 16–17 to 18–20 years of age. Mesosomy was a predominant feature in girls of both age groups (48% of all studied girls aged 16–17 and 40.0% of all studied girls aged 18–20). Girls with megalosomal body type constituted 24.0 and 26.5%, respectively; girls with leptosomal body type constituted 20% in all age groups; girls with undefined body type constituted 8.0% and 13.5%, respectively. The content of the muscular component of the soma demonstrated significant constitutional differences between these parameters. In comparison of the studied groups, there was an insignificant increase in the absolute indices of the muscle component with a decrease in the relative indices - the mass of the muscle component to body weight – with increasing age.Conclusion. The data obtained demonstrate significant constitutional features of the absolute and relative (percentage) content of the muscle component of the body as an important aspect of the female physical status. This information is relevant for both theoretical and practical medicine.
Guía de Práctica Clínica para la prevención y detección temprana de las alteraciones del embarazo
Authors: Amaya-Guío Jairo , Rodríguez-Merchán Diana Milena , Osorio-Sánchez Dimelza , Barrera-Barinas Alexander , Desarrollador de la Guía Representantes Grupo 
Published: April 2020

Objetivo: realizar recomendaciones para la prevención, detección temprana y tratamiento de las complicaciones del embarazo en Colombia.Materiales y métodos: el grupo desarrollador de la Guía (GDG) elaboró esta GPC durante 2011-2012 acorde con la Guía Metodológica para la elaboración de Guías de Atención Integral en el Sistema General de Seguridad Social en Salud colombiano, basándose en la evidencia científica disponible y sumando la participación activa de grupos de pacientes, sociedades científicas y grupos de interés. En particular, la evidencia de esta guía fue adaptada de la GPC “Antenatal care: routine care for the healthy pregnant woman” (National Institute of Care and Health Excellence -NICE -2008) y actualizada por medio de procedimientos sistemáticos, tanto para la búsqueda y valoración de la evidencia como para la generación de recomendaciones. El nivel de evidencia y la fuerza de las recomendaciones fueron expresadas por medio del sistema del Scottish Intercollegiate Guidelines Network (SIGN).Resultados: se priorizaron 30 preguntas clínicas, las cuales generaron diversas recomendaciones relacionadas con la organización administrativa del control prenatal, el manejo de las molestias más frecuentes, las actividades para garantizar el bienestar materno-fetal e indicaciones para detectar precozmente aquellas patologías que pueden alterar el embarazo de curso normal, entre otras.Conclusión: se presenta una versión resumida de las recomendaciones y evidencia de esta sección, que se espera sea adoptada por los profesionales de la salud encargados de la atención del embarazo en el país para disminuir la morbilidad y mortalidad asociada a la gestación. Palabras clave: guías de práctica clínica, práctica clínica basada en la evidencia, embarazo, atención prenatal, Colombia.
Enfermedad de Wernicke Korsakoff en hiperémesis gravídica: presentación de un caso en el Hospital Hipólito Unanue de Lima, Perú y revisión de la literatura
Authors: Grandez-Urbina J. Antonio , Fernández-Luque Jorge L. , Castañeda-Alarcón David , Cruz-Reyes Rubén , Angulo-Galindo Augusto , Valdivia-Cabrera Roger 
Published: April 2020

Objetivos: la encefalopatía de Wernicke es un desorden severo causado por deficiencia de vitamina B1. Esta enfermedad rara vez diagnosticada, es más prevalente de lo que se reporta, por lo que nuestro objetivo es presentar un caso inusual y hacer una revisión de la literaturaute; por bajos B1. Esta enfermedad, rara vez diagnosticada, es más prevalente de lo que se reporta por lo que nuestro objetivo es presentar un caso inusual y hacer una revisión de la literatura.Materiales y métodos: se presenta el caso de una mujer gestante de 29 años de edad, con tiempo de gestación de 12 semanas, que ingresa al servicio de Emergencia del Hospital Nacional Hipólito Unanue, hospital de referencia a nivel nacional, ubicado en Lima, Perú, que atiende pacientes de bajo nivel socioeconómico. Como sintomatología presentaba náuseas, vómitos incoercibles, amaurosis nocturna con manifestaciones psicóticas, ataxia y baja ponderal del 12% de peso. Se diagnosticó por bajos niveles séricos de vitamina B1. Para la búsqueda sistemática se utilizaron las palabras clave: Síndrome de Wernicke Korsakoff e Hiperemesis gravídica en bases de datos Pubmed, Scopus, Embase, DOAJ, SciELO, Latindex, Redalyc y Lilacs.Resultados: se encontraron 135 artículos, de los cuales 45 estaban relacionados directamente con el tema, de estos se seleccionaron 6 reportes de caso y 11 revisiones del tema.Conclusiones: la enfermedad de Wernicke Korsakoff asociada a hiperémesis gravídica es de difícil diagnóstico, y necesita manejo rápido y oportuno para conservar la salud de la madre y el feto.
Piometra por Streptococcus agalactiae tras parto vaginal eutócico. Presentación de un caso y revisión de la literatura
Authors: Redondo-Aguilar Rosario , Abulhaj-Martínez Mariam , Cruz-Martínez Milagros , Hidalgo-Carmona Esther , Padilla-Vinuesa Carmen 
Published: April 2020

Objetivo: analizar un caso clínico de piometra por Streptococcus agalactiae tras parto vaginal. Revisar los factores de riesgo, el diagnóstico y el tratamiento de esta entidad.Materiales y métodos: se presenta el caso de una puérpera de 35 años con cuatro partos anteriores y parto vaginal diez días antes, quien consulta por sangrado genital abundante al Hospital Universitario San Cecilio de Granada (España) que realiza la atención obstétrico-ginecológica de la población sur de Granada y es centro de referencia de los Hospitales Básicos del Área Sanitaria Sur de la provincia. La ecografía transvaginal muestra cavidad uterina ocupada por contenido heterogéneo. Se practica legrado obteniéndose abundante material purulento, se hace diagnóstico de piometra y se instaura tratamiento antibiótico de amplio espectro. Cultivo positivo para Streptococcus agalactiae. Posteriormente presenta recidiva que precisa drenajes y tratamiento antibiótico intravenoso con clindamicina e imipenem, con buena evolución. Se realiza una búsqueda bibliográfica en las bases de datos: Pubmed, Cochrane y UpToDate utilizando los términos de búsqueda piometra posparto, endometritis posparto, Streptococcus agalactiae.Resultados: se encontraron 833 artículos en las bases de datos, de los cuales se seleccionaron 40 sobre casos de piometra o endometritis posparto en humanos incluyendo finalmente 14 artículos, 3 correspondieron a casos clínicos y 11 a revisiones del tema.Conclusiones: la aparición de piometra tras un La ecografía transvaginal muestra cavidad uterina parto vaginal eutócico es poco frecuente en humaocupada por contenido heterogéneo. Se practica nos, pero debe considerarse como posible entidad legrado obteniéndose abundante material purulen-etiológica en casos de fiebre puerperal con factores to, se hace diagnóstico de piometra y se instaura de riesgo asociados. El diagnóstico se basa en una tratamiento antibiótico de amplio espectro. Cultivo buena exploración clínica y ecográfica, y se debe positivo para Streptococcus agalactiae. Posteriormente instaurar de forma precoz un tratamiento antibiótico de amplio espectro y realizar drenaje del mismo.
Pseudoquistes del cordón umbilical: reporte de un caso clínico y revisión de la literatura
Authors: Arango-Pineda Johana Carolina , Olivares-Concha Diana Soley , Rojas-Salazar María Fernanda , Quintero-Mejía Juan Carlos , Saldarriaga-Gil Wilmar 
Published: April 2020

Introducción: los quistes del cordón umbilical se clasifican en pseudoquistes y quistes verdaderos, la diferencia radica en la presencia de epitelio al interior del quiste en la revisión histológica. El objetivo de este documento es reportar un caso de pseudoquiste de cordón umbilical en Colombia y hacer una revisión de la literatura respecto a su origen, las diferencias diagnósticas y su posible asociación con alteraciones congénitasMateriales y métodos: se presenta el caso de una paciente de veinte años remitida al Hospital Universitario del Valle, Cali, institución de tercer nivel de complejidad, a quien se le encuentran en ultrasonido en la parte proximal del cordón umbilical múltiples imágenes hipoecoicas, a la semana 16. A las 32 semanas se realiza cesárea por trabajo de parto pretérmino, podálico, con recién nacido de sexo femenino, sin defectos congénitos, cariotipo 46, XX. El cordón umbilical tenía apariencia hidrópica, en la observación microscópica se advirtieron los 3 vasos, edema de la gelatina de Wharton con cambios mixoides, sin epitelio, se concluye con diagnóstico de pseudoquistes del cordón umbilical. Se realizó una búsqueda bibliográfica en las bases de datos Medline, Ovid, ScienceDirect y Cochrane Reviews con los términos cordón umbilical, pseudoquiste y quiste del cordón umbilical.Conclusión: los pseudoquistes y quistes verdaderos del cordón umbilical son de buen pronóstico cuando son el único hallazgo anormal en el feto, pero los quistes tienen una importante asociación con otros defectos anatómicos y con alteraciones cromosómicas.
Induksi Kalus Gaharu dengan NAA dan BAP Secara In Vitro
Authors: Wahyuni Amalina , Satria Benni , Zainal Aprizal 
Published: April 2020

<p>Agarwood has a high economic value because they have many benefits that cause agarwood to be hunted to meet the increasing market demand and its presence in nature is decreasing due to unwise conventional retrieval systems.The research objectives were to study the effect and determine the best concentration of NAA and BAP in callus induction of agarwood (Aquilaria malaccensis Lamk.). This research was conducted in the Tissue Culture Laboratory, Faculty of Agriculture, Andalas University from October 2018 until January 2019. The leaves of Agarwood were used as explants. The method used was completely randomized design (CRD) with different combinations of NAA and BAP (1.5 + 0.5 ppm, 3.0 + 0.5 ppm, 1.5 + 1.0 ppm, and 3.0 + 1.0 ppm). Data were analyzed using the F test and continued with Duncan’s Multiple Range Test at a level of 5%. The results showed that there was the effects of combination of growth regulator substances NAA and BAP on callus induction of agarwood. The concentration of NAA 3.0 ppm + BAP 0.5 ppm was the best in inducing callus with the percentage of explants life and explants form callus with 100%. The color of callus obtained varies, yellow, brownish yellow and brown. All structures callus gained in this research was compact. Yellow callus and compact structure could be utilized for organogenesis.</p>
Reducing sitting at work: process evaluation of the SMArT Work (Stand More AT Work) intervention
Authors: Biddle Stuart JH , O'Connell Sophie E , Davies Melanie , Dunstan David , Edwardson Charlotte , Esliger Dale W , Gray Laura J , Yates Thomas , Munir Fehmidah 
Published: April 2020

Abstract
Background: Office based workers accumulate high amounts of sitting time. Stand More AT (SMArT) Work aimed to reduce occupational sitting time and a cluster randomised controlled trial demonstrated it was successful in achieving this aim. The purpose of this paper is to present the process evaluation of the SMArT Work intervention.Methods: Questionnaire data were collected from intervention participants at 6 (n=58) and 12 months (n=55). Questionnaires sought feedback on the different components of the intervention (education, height-adjustable desk, Darma cushion, behaviour feedback, progress chats (coaching) with research team, action planning/goal setting diary) and experiences of evaluation measures. Control participants (n=37) were asked via questionnaire at 12 month follow up about the impact of the study on their behaviour and any lifestyle changes made during the study. Participants from both arms were invited to focus groups to gain a deeper understanding of their experiences upon completion of 12 month follow up.Results: Focus group and questionnaire data showed a positive attitude towards the height-adjustable workstation with a high proportion of participants using it every day (62%). Most participants (92%) felt the education seminar increased their awareness of the health consequences of too much sitting and motivated them to change their behaviour. Receiving feedback on their sitting time and support from the research team also encouraged behaviour change. The Darma cushion and action planning/goal setting diary were seen to be less helpful for behaviour change. Benefits experienced included fewer aches and pains, improved cognitive functioning, increased productivity, more energy, and positive feelings about general health.Conclusions: Key elements of the programme identified as facilitating behaviour change were: the educational seminar, the height-adjustable workstation, behavioural feedback and regular contact with research staff through regular progress chats. Trial Registration: ISRCTN, ISRCTN10967042, Registered on 2 February 2015, http://www.isrctn.com/ISRCTN10967042
Survival and prognostic factor analyses in malignant giant cell tumour of bone
Authors: Zhang Jin , Wang Xin , Lin Feng , Xu Guijun , Wu Haixiao , Duan Jincai , Mao Min , Zhang Chao 
Published: April 2020

Abstract
Background: The characteristics and survival of patients with malignant giant cell tumour of bone (GCTB) have not been investigated thoroughly due to the rarity of the disease. We evaluated these factors in a large cohort in the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database.
Methods: Data from patients who were diagnosed with malignant GCTB from 1975 to 2016 were extracted from the SEER database. The overall survival (OS) was calculated by Kaplan–Meier analysis, and intergroup differences were tested by the log-rank test. Univariate and multivariate Cox proportional hazard regression analyses were conducted to identify the independent survival factors.
Results: A total of 325 patients with malignant GCTB were included. The overall 1-, 5-, and 10-year survival rates were 94.3% (95% CI: 91.7-96.8), 82.3% (95% CI: 77.9-86.6), and 80.1% (95% CI: 75.4-84.7), respectively. A potential non-linear J-shaped dose–response relationship between the age or diagnosis year and survival. Multivariate Cox regression showed poor survival in patients with age from 35 to 60 years (hazard ratio (HR) =9.99, 95% CI: 1.34-74.80, P =0.025), age older than 60 years (HR=62.03, 95% CI: 7.94-484.38, P <0.001), with stage T2 disease (HR=4.85, 95% CI: 1.52-15.47, P =0.008), with stage T3 disease (HR=6.09, 95% CI: 1.03-36.23, P =0.047), and with distant tumours (HR=2.76, 95% CI: 1.14-6.65, P =0.024), and extraskeletal sites (HR=3.33, 95% CI: 1.02-10.85, P =0.046).
Conclusions: This large population-based series described the clinical characteristics of malignant GCTB. Patients with age >34 years, stage T2/3 disease, distant disease and extra-skeletal sites had more odds to be with worse survival.
Enabling routine β-Thalassemia Prevention and Patient Management by Scalable, Combined Thalassemia and Hemochromatosis Mutation Analysis
Authors: Hashmi Ghazala , Qidwai Asim , Fernandes Kristopher , Seul Michael 
Published: April 2020

Abstract
Abstract:
Background : Beta (β)-thalassemia is one of the most common inherited disorders worldwide, with high prevalence in the Mediterranean, the Middle East and South Asia. Over the past 40 years, many countries have implemented awareness and prevention campaigns that have greatly reduced the incidence of affected child births. In contrast, much remains to be done in South-Asia. Thus, for Pakistan, current estimates of the number of children born with thalassemia are at ~7,000 per annum, with no sign of improvement. Although there is good agreement that intermarriage of carriers is a principal source of the high prevalence of the disorder, effective tools for screening and diagnosis on which to base prevention programs are not readily available.
Methods : Here, we present results for a novel “LeanSequencing” process to identify 18 β-thalassemia and related sickle cell anemia, and simultaneously a set of 3 hemochromatosis mutations in a multi-ethnic population of 274 pediatric and adolescent patients treated at Afzaal Memorial Thalassemia Foundation hospital in Karachi, Pakistan.
Results : We found substantial differences in the abundance of disease-causing mutations among the principal ethnic groups in our cohort. We also found the hemochromatosis mutation H63D C > G in 61 (or 22.1%) of our patients including 7 (or 2.6%) homozygotes.
Conclusions : To our knowledge, this is the first screen combining β-thalassemia and hemochromatosis mutations in a single test, so as to facilitate the early identification of patients who may be at increased potential risk for complications from iron overload and thereby to improve the prospective management of thalassemia patients.
Community knowledge, attitude and practices on mosquitoes and mosquito-borne viral diseases in Kinshasa, Democratic Republic of the Congo
Authors: mbanzulu kennedy makola , Mboera Leonard E.G. , Wumba Roger , Zanga Josué K. , Luzolo Flory K. , Misinzo Gerald , Kimera Sharadhuli I. 
Published: April 2020

Abstract
Background

Mosquito-borne viral diseases (MBVD) are among the important human and animal health threats globally. Gaining insights on behaviours and practices of local population on MBVD can improve understanding of socio-demographic and cultural factors to be addressed in intervention packages. This study was carried out to explore community knowledge, attitudes and practices regarding mosquitoes and MBVD in Kinshasa, the Democratic Republic of the Congo (DRC).

Methods

A cross sectional survey involving heads of household was carried out in Kinshasa, DRC, between January and April 2019. Information on socio-demographic characteristics, knowledge, attitudes and practices on mosquito and MBVD was collected through a questionnaire. Data analysis was performed using Epi Info 7.

Results

A total of 1,464 representatives were involved in the study. Of these, 69% were under 44 years of age, 60.7% were females and the majority (90.2%) were educated. One-third of the houses had insect window screens, 61.2% had open garbage cans, 33.4% had outdoor water storage units, 25.1% had stagnant water collection and 22.5% had water containers. The majority (80.3%) of the respondent mentioned polluted water bodies as the main mosquito breeding places. Yellow fever (86.6%) was the most commonly known MBVD. Overall, 12% of the respondents knew that mosquitoes are vectors of these viruses. Majority of respondents (72.5%) felt to be at risk of contracting MBVD. Blocked draining water channels, dirty, agriculture, house and road construction, animal rearing and automobile garages were associated with mosquito abundance. Health professionals, family member, radio/television and/or school/university were the main source of information. Cleaning environment (58%) and/or use of insecticides (25%) were the main measures implemented in controlling mosquitoes. Mosquito net ownership (87.4%) and use (67%) were high. The greater overall of knowledge score (OR: 1.4; p =0.1), attitude (OR: 1.22; p =0.1) were not predictor of good practice.

Conclusion

Most of the residents of Kinshasa had limited knowledge on the role of mosquitoes in the transmission of pathogenic viruses in both humans and animals. Raising awareness and educational sessions are essential in empowering the community on the correct attitudes and practices in order to effectively manage the risk posed by MBVD.