bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aristotle
Authors: Irwin Terence 
Published: July 2020

Abstract
Aristotle agrees with Plato that virtue requires the cooperation of the rational and the non-rational parts of the soul, and that the virtuous person is always better off than the non-virtuous, even though virtue alone is not sufficient for happiness. To strengthen Plato’s argument for this claim, he offers a more detailed account of the nature of happiness, and of the relation between virtue and happiness. Since happiness is the supreme human good, it should be identified with rational activity in accordance with virtue in a complete life, in which external circumstances are favourable. A virtue of character is the appropriate agreement between the rational and the non-rational parts of the soul, aiming at fine action (i.e., action that promotes the common good). This requirement of appropriate agreement distinguishes virtue from continence (mere control of the rational over the non-rational part). To show that a life of virtue, so defined, promotes the agent’s happiness, Aristotle argues that one’s own happiness requires the right kind of friendship with others, in which one aims at the good of others for their own sake.
Aquinas
Authors: Irwin Terence 
Published: July 2020

Abstract
Aquinas develops Aristotelian themes as a foundation for his account of the Christian virtues. The will is both rational, being directed towards the ultimate good, and free, being determined by practical reason about what contributes to the ultimate good. Virtue is the good use of free will; it requires both the appropriate training of the passions (the non-rational part of the soul) and the correct practical reason. Practical reason finds the first principles of the natural law (the rational principles that are suitable for human nature), and the action-guiding rules that specify the implications of the natural law for human beings with a social nature, and for human society. The virtues, embodying the natural law, guide us towards the good that is proper to human beings. They do not guide us all the way, because we are subject to the influence of the sins that turn us away from God. Divine grace moves our free will to overcome the effects of these sins, and to form the Christian virtues that lead us towards the complete good.
Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs). IX. Identification of two red quasars at z &gt; 5.6
Authors: Kato Nanako , Matsuoka Yoshiki , Onoue Masafusa , Koyama Shuhei , Toba Yoshiki , Akiyama Masayuki , Fujimoto Seiji , Imanishi Masatoshi , Iwasawa Kazushi , Izumi Takuma , Kashikawa Nobunari , Kawaguchi Toshihiro , Lee Chien-Hsiu , Minezaki Takeo , Nagao Tohru , Noboriguchi Akatoki , Strauss Michael A 
Published: July 2020

Abstract
We present the first discovery of dust-reddened quasars (red quasars) in the high-z universe (z &gt; 5.6). This is a result from the Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs) project, which is based on the sensitive multi-band optical imaging data produced by the Hyper Suprime-Cam (HSC) Subaru Strategic Program survey. We identified four red quasar candidates from the 93 spectroscopically confirmed high-z quasars in the SHELLQs sample, based on detections in the Wide-field Infrared Survey Explorer (WISE) data at 3.4 and 4.6 μm (rest-frame ∼5000–6500 Å). The amount of dust reddening was estimated with spectral energy distribution (SED) fits over optical and mid-infrared wavelengths. Two of the four candidates were found to be red quasars with dust reddening of E(B − V) &gt; 0.1. The remaining SHELLQs quasars without individual WISE detections are significantly fainter in the WISE bands and bluer than the red quasars, although we did detect them in the W1 band in a stacked image. We also conducted the same SED fits for high-z optically-luminous quasars, but no red quasar was found. This demonstrates the power of Subaru HSC to discover high-z red quasars, which are fainter than the limiting magnitudes of past surveys in the rest-frame ultraviolet, due to dust extinction.
Polynomial daugavet centers
Authors: Santos Elisa R 
Published: July 2020

AbstractA polynomial $Q: X \rightarrow Y$ is called a polynomial Daugavet center if the equality $$\begin{equation*} \|Q + P \| = \|Q\| + \|P \| \end{equation*}$$is satisfied for all rank-one polynomials $P: X \rightarrow Y$. In this paper, we present geometric characterizations of polynomial Daugavet centers. We show that if $Q$ is a polynomial Daugavet center, then every weakly compact polynomial $P$ also satisfies this equation. Finally, we prove that if $Y$ is a subspace of a Banach space $E$ and $Q: X \rightarrow Y$ is a polynomial Daugavet center, then $E$ can be equivalent renormed in such a way that the norm on $Y$ is not modified and $J \circ Q: X \rightarrow E$ is a polynomial Daugavet center. We also present some examples of polynomial Daugavet centers.
Non-invasive stimulation of the social brain: the methodological challenges
Authors: Penton Tegan , Catmur Caroline , Banissy Michael J , Bird Geoffrey , Walsh Vincent 
Published: July 2020

AbstractUse of non-invasive brain stimulation methods (NIBS) has become a common approach to study social processing in addition to behavioural, imaging and lesion studies. However, research using NIBS to investigate social processing faces challenges. Overcoming these is important to allow valid and reliable interpretation of findings in neurotypical cohorts, but also to allow us to tailor NIBS protocols to atypical groups with social difficulties. In this review, we consider the utility of brain stimulation as a technique to study and modulate social processing. We also discuss challenges that face researchers using NIBS to study social processing in neurotypical adults with a view to highlighting potential solutions. Finally, we discuss additional challenges that face researchers using NIBS to study and modulate social processing in atypical groups. These are important to consider given that NIBS protocols are rarely tailored to atypical groups before use. Instead, many rely on protocols designed for neurotypical adults despite differences in brain function that are likely to impact response to NIBS.
Phylogeographic Estimation and Simulation of Global Diffusive Dispersal
Authors: Louca Stilianos 
Published: July 2020

AbstractThe analysis of time-resolved phylogenies (timetrees) and geographic location data allows estimation of dispersal rates, for example, for invasive species and infectious diseases. Many estimation methods are based on the Brownian Motion model for diffusive dispersal on a 2D plane; however, the accuracy of these methods deteriorates substantially when dispersal occurs at global scales because spherical Brownian motion (SBM) differs from planar Brownian motion. No statistical method exists for estimating SBM diffusion coefficients from a given timetree and tip coordinates, and no method exists for simulating SBM along a given timetree. Here, I present new methods for simulating SBM along a given timetree, and for estimating SBM diffusivity from a given timetree and tip coordinates using a modification of Felsenstein’s independent contrasts and maximum likelihood. My simulation and fitting methods can accommodate arbitrary time-dependent diffusivities and scale efficiently to trees with millions of tips, thus enabling new analyses even in cases where planar BM would be a sufficient approximation. I demonstrate these methods using a timetree of marine and terrestrial Cyanobacterial genomes, as well as timetrees of two globally circulating Influenza B clades. My methods are implemented in the R package “castor.” [Independent contrasts; phylogenetic; random walk; simulation; spherical Brownian motion.]
Can You Stall a Baclofen Pump During a Magnetic Rod Lengthening?
Authors: Hardesty Christina K. , Janas Michelle 
Published: July 2020

Introduction:
Baclofen pumps are susceptible to magnetic forces because of the internal drug delivery mechanism. Magnetically controlled growing rods, sometimes implanted in the patients who have pumps, are lengthened using a device that generates a magnetic field. No previous study has determined if the external remote controller (ERC) can stall a baclofen pump during a rod lengthening.

Methods:
Two baclofen pumps were placed in proximity to the ERC while it generated a magnetic field. This process was repeated with variations in the distance between pump and ERC, speed (dose) of the pump, lengthening time, and position of the ERC relative to the pump. The presence or absence of a stall was recorded.

Results:
To stall a baclofen pump, the ERC needed to be running consistently for at least 30 mm of lengthening. The pump would not stall if it was >1 cm away from the ERC. The pump was more likely to stall if it was positioned in front of or behind the magnetic field, as opposed to the center of the field.

Discussion:
As long as the baclofen pump is >1 cm away from the ERC, the pump will not stall, regardless of the length of time the ERC generates a magnetic field.
Predictors and Motivation of Preceptors′ Interest in Precepting of Pharmacy Interns—Do We Have a Useful Questionnaire?
Authors: Golić Jelić Ana , Tasić Ljiljana , Odalović Marina , Stoisavljević Šatara Svjetlana , Stojaković Nataša , Marinković Valentina 
Published: July 2020

Purpose:
To determine the potential value of an adapted questionnaire to discover the predictors of preceptors' higher interest in precepting pharmacy interns and to evaluate preceptors' motivational factors and incentives for teaching as well as their professional satisfaction.

Method:
A link to the survey study of adapted questionnaire (JSAMPPP) was e-mailed to all pharmacists registered with the Pharmaceutical Chamber of the Republic of Srpska. Pharmacists' demographic and work experience characteristics, their attitudes related to motivation for precepting, value of incentives for precepting, job satisfaction, and influence of interns on pharmacists' professional practice were obtained.

Results:
Half of the preceptors who reported feeling satisfied with their professional life also showed interest in teaching. In addition, teaching pharmacy students positively contributed to the overall job satisfaction of the preceptors. Pharmacy preceptors were found to be most motivated by intrinsic factors. The most valued incentives reported were those related to continuing education.

Conclusions:
The adapted questionnaire has potential value and it revealed the following predictors of preceptors' higher interest in precepting: enjoyment of teaching, satisfaction with professional life, satisfaction as a pharmacy preceptor, and interns' influence on preceptors. These identified predictors can be emphasized to improve pharmacy students' internship experiences, thereby reinforcing the pharmacy profession.
Tranexamic Acid for Melasma Treatment: A Split-Face Study
Authors: Ebrahim Howyda M. , Said Abdelshafy Ahmed , Khattab Fathia , Gharib Khaled 
Published: July 2020

BACKGROUND
Melasma is an acquired hyperpigmented skin disorder. Tranexamic acid (TXA) prevents ultraviolet radiation induced pigmentation in melasma through interfering with the plasminogen–plasmin pathway.

OBJECTIVE
This study was conducted to evaluate the therapeutic effect and safety of TXA by intradermal injection versus TXA with microneedling for melasma treatment.

METHODS
Fifty-six female patients with bilateral symmetrical melasma were recruited in a split-face study. All patients received an intradermal injection of TXA on one side of the face, and the other side received TXA with microneedling for 6 sessions at 2 weeks intervals. Clinical efficacy was assessed using a modified Melasma Area Severity Index (mMASI) score at the baseline and after treatment. Global photographs underwent blinded review by 2 dermatologists. Patient self-assessment and satisfaction were recorded.

RESULTS
After the treatment, the mMASI score was significantly reduced compared with the baseline in both treated sides (p < .001). No significant difference between both treated sides (p > .05). Patient satisfaction was higher in the microneedling-treated side than the intradermal-injected side (p < .001). No significant adverse effects were observed in both treated sides.

CONCLUSION
Intradermal injection and microneedling of TXA could be safe and effective in melasma treatment. Microneedling of TXA was significantly more satisfying to the patients.
ULTRAWIDEFIELD PSEUDOCOLOR RETINAL IMAGING VERSUS REAL-COLOR FUNDUS PHOTOGRAPHY FOR DETECTION OF INTRARETINAL PIGMENT MIGRATION IN AGE-RELATED MACULAR DEGENERATION
Authors: Ramtohul Prithvi , Gascon Pierre , Comet Alban , Denis Danièle 
Published: July 2020

Purpose:
To compare pseudocolor Optos ultrawidefield (UWF) retinal images with conventional real-color fundus photography (CFP) for detecting macular hyperpigmentary changes in intermediate age-related macular degeneration.

Methods:
This retrospective study included 50 patients diagnosed with intermediate age-related macular degeneration. All patients underwent Optos imaging and CFP. The overall accuracy to visualize hyperpigmentation and its morphologic features was graded by two independent readers using a standardized grid. Structural and en face optical coherence tomography images were correlated with UWF and CFP images to determine spatial correspondence of pigment clumping on fundus images and hyperreflective foci on optical coherence tomography.

Results:
One hundred eyes of 50 patients had hyperpigmentary changes on funduscopic examination and were included. The intragraders and intergraders agreements were high for all measurements (P < 0.001). At least one hyperpigmentary changes within the standardized grid was detected in 93% using CFP and 100% using UWF camera (P = 0.02). The total area of hyperpigmentation measured on UWF images was significantly higher than on CFP images (P < 0.001). There was a significant correlation between the presence of hyperpigmentary changes on both CFP and UWF images and hyperreflective foci on structural optical coherence tomography (P < 0.001).

Conclusion:
Ultrawidefield fundus images allow high detection and accurate quantification of macular hyperpigmentary changes in intermediate age-related macular degeneration compared with conventional CFP.
REFRACTIVE OUTCOMES AFTER SUTURELESS INTRASCLERAL FIXATION OF INTRAOCULAR LENS WITH PARS PLANA VITRECTOMY
Authors: Lee Ramon , Govindaraju Viren , Farley Nathan D. , Abbey Ashkan M. , Stem Maxwell S. , Shields Ryan A. , Wa Christianne A. , Williams George A. , Faia Lisa J. , Hassan Tarek S. , Wolfe Jeremy D. 
Published: July 2020

Purpose:
To evaluate the refractive outcomes of sutureless intrascleral fixation of intraocular lens with pars plana vitrectomy.

Method:
A retrospective, consecutive cohort from multiple surgeons of a single center. Primary outcomes included spherical equivalent (SEQ) and change in SEQ (ΔSEQ) from preoperative intraocular lens power calculations. Secondary outcomes included refractive outcomes of fixation at 1.5 mm, 2 mm, and 2.5 mm posterior to the limbus.

Results:
In total, 84 eyes of 80 patients were included. Preoperative logarithm of the minimum angle of resolution visual acuity was 1.21 ± 0.68 (20/320). The mean follow-up time was 2.33 ± 1.36 years. At 3 months, SEQ was −0.50 ± 1.59 D and ΔSEQ was 0.58 ± 1.49 D. At 1 year, SEQ was −0.55 ± 1.32 D and ΔSEQ was 0.39 ± 1.42 D. At the last follow-up, logarithm of the minimum angle of resolution visual acuity was 0.34 ± 0.34 (20/40), SEQ was −0.51 ± 1.44 D, and ΔSEQ was 0.57 ± 1.27 D. There was no difference between SEQ or ΔSEQ throughout follow-up (P = 0.97 and P = 0.96, respectively). At fixation distances more posterior to the limbus, mean ΔSEQ was more hyperopic at 3 months, 1-year, and the last follow-up (P = 0.02, P = 0.01, and P = 0.006, respectively).

Conclusion:
Refractive outcomes for sutureless intrascleral fixation of intraocular lens with pars plana vitrectomy were favorable and showed stability postoperatively. These results may aid surgeons achieve better desired refractive outcomes for this technique.
AQUEOUS HUMOR CYTOKINE LEVELS AND REBOUND MACULAR EDEMA AFTER CONBERCEPT TREATMENT IN PATIENTS WITH CENTRAL RETINAL VEIN OCCLUSION
Authors: Yang Kai-Bo , Sun Xu-Yang , Sun Li-Ping , Li Jun , Liu Zhe-Li , Zhang Han 
Published: July 2020

Purpose:
This study aimed to investigate the effect of intravitreal conbercept (IVC) injections on the aqueous humor concentrations of angiogenic and inflammatory cytokines in patients with macular edema (ME) due to central retinal vein occlusion and to determine whether changes in cytokine levels after IVC are associated with the development of rebound ME.

Methods:
Forty-nine patients with ME caused by central retinal vein occlusion were included in this retrospective study. Monthly doses of IVC were administered for three months, followed by a Pro Re Nata dosing regimen. Rebound ME was defined as ≥110% increase in the foveal thickness compared with the baseline. Whenever injections were administered, aqueous humor samples were obtained. Multiplex bead assay was used to measure seven angiogenic and inflammatory cytokines in aqueous humor samples.

Results:
At baseline, patients with central retinal vein occlusion showed significantly higher aqueous humor concentrations of vascular endothelial growth factor, placental growth factor, monocyte chemoattractant protein-1, platelet-derived growth factor-AA, IL-6, IL-8, and IL-12. At 1-month and 2-month follow-up after IVC, significantly decreased concentrations of all cytokines were observed. During the 12-month follow-up period, 6 of the 49 eyes (12.2%) showed rebound ME after IVC. Patients with rebound ME showed significantly elevated levels of inflammatory but not angiogenic cytokines.

Conclusion:
Angiogenic and inflammatory cytokines were overexpressed in patients with ME caused by central retinal vein occlusion. Conbercept treatment influenced the concentrations of various inflammatory cytokines and reduced aqueous vascular endothelial growth factor and placental growth factor concentrations. Rebound ME may occur due to disruption of the balance between angiogenic and inflammatory cytokines and an accompanying excess of inflammatory cytokines but not angiogenic cytokines, after antivascular endothelial growth factor therapy.
Intradural artery dilation during experimentally induced migraine attacks
Authors: Christensen Casper E. , Younis Samaira , Lindberg Ulrich , de Koning Patrick , Tolnai Daniel , Paulson Olaf B. , Larsson Henrik B.W. , Amin Faisal M. , Ashina Messoud 
Published: July 2020

Abstract
The middle meningeal artery is a proposed surrogate marker for activation of trigeminal nociceptors during migraine. Previous studies focused on the extracranial part of the artery; hence, vasoreactivity in the intradural arteries during migraine is unknown. Thirty-four patients with migraine without aura were given sildenafil on one day and calcitonin gene-related peptide on another in double-blind crossover fashion. Patients were scanned with 3.0 T MR angiography before drug administration and again 6 hours later during induced attacks of migraine. We measured circumference of the intradural segment of the middle meningeal artery before and during induced migraine attacks. The middle cerebral and superficial temporal arteries were also examined. Fourteen patients had attacks during the second scan after both study drugs and 11 had a migraine after either one or the other, resulting in a total of 39 attacks included in the final analysis. Mean circumference of the intradural middle meningeal artery at baseline was 3.18 mm with an increase of 0.11 mm during attacks (P = 0.005), corresponding to a relative dilation of 3.6% [95% CI: 1.4%-5.7%]. Middle cerebral artery dilated by 9.4% [95% CI: 7.1%-11.7%] and superficial temporal artery by 2.3% [95% CI: 0.2%-4.4%]. Our study shows that the intradural middle meningeal artery and the middle cerebral artery are dilated during migraine induced by calcitonin gene-related peptide as well as sildenafil. We propose that intradural vasculature is affected by migraine-driven activation of trigeminal afferents during migraine attacks.
Trigeminal neuralgia diffusivities using Gaussian process classification and merged group tractography
Authors: Chen David Qixiang , Zhong Jidan , Chu Powell P.W. , Fei Li Cathy Meng , Hodaie Mojgan 
Published: July 2020

Abstract
Imaging of trigeminal neuralgia (TN) has demonstrated key diffusion tensor imaging-based diffusivity alterations in the trigeminal nerve; however, imaging has primarily focused on the peripheral nerve segment because of previous limitations in reliably segmenting small fiber bundles across multiple subjects. We used Selective Automated Group Integrated Tractography to study 36 subjects with TN (right-sided pain) and 36 sex-matched controls to examine the trigeminal nerve (fifth cranial nerve [CN V]), pontine decussation (TPT), and thalamocortical fibers (S1). Gaussian process classifiers were trained by scrolling a moving window over CN V, TPT, and S1 tractography centroids. Fractional anisotropy (FA), generalized FA, radial diffusivity, axial diffusivity, and mean diffusivity metrics were evaluated for both groups, analyzing TN vs control groups and affected vs unaffected sides. Classifiers that performed at greater-than-or-equal-to 70% accuracy were included. Gaussian process classifier consistently demonstrated bilateral trigeminal changes, differentiating them from controls with an accuracy of 80%. Affected and unaffected sides could be differentiated from each other with 75% accuracy. Bilateral TPT could be distinguished from controls with at least 85% accuracy. TPT left–right classification achieved 98% accuracy. Bilateral S1 could be differentiated from controls, where the affected S1 radial diffusivity classifier achieved 87% accuracy. This is the first TN study that combines group-wise merged tractography, machine learning classification, and analysis of the complete trigeminal pathways from the peripheral fibers to S1 cortex. This analysis demonstrates that TN is characterized by bilateral abnormalities throughout the trigeminal pathway compared with controls and abnormalities between affected and unaffected sides. This full pathway tractography study of TN demonstrates bilateral changes throughout the trigeminal pathway and changes between affected and unaffected sides.