bluuebunny/crossref_metadata_2025_split huggingface dataset:
Egg quality traits, blood biochemical parameters and performance of laying hens fed diet included processed oak fruit
Authors: Bekri Fatemeh , Torki Mehran 
Published: October 2020

AbstractTo investigate the effects of replacing maize with various levels of raw and processed oak fruit in diet on productive performance of laying hens and egg quality traits, the total number of 168 Bovans white laying hens (30‐week age) were randomly distributed between 28 replicate cages and assigned to 7 experimental diets. Based on a 2 × 3 factorial arrangement of treatments including two dietary levels (10% and 20%) of raw, soaked or boiled oak fruit as well as a corn–soybean meal‐based diet, 7 experimental diets with 4 replicates and 6 chickens per replicate cages were evaluated during an 8‐week period. The data were analysed using GLM procedure of SAS. Significantly higher feed consumption was observed in 10% boiled oak compared with soaked oak (p < .05). Significantly improved feed conversion ratio was observed in 10% boiled oak compared with soaked oak (p < .05). Diet inclusion of 10% oak fruit caused significant increased shell weight. Significant interaction between oak level and processing method on the egg‐specific gravity was observed (p < .05), and higher egg‐specific gravity was detected in hens fed the diets included 20% boiled or 20% raw oak compared to 20% soaked oak. Significantly increased blood LDL level was observed in hens fed the diets that included boiled and soaked oak (p < .05). In conclusion, based on the results of the present study, 10% boiled oak can be substituted corn in diet of laying hens with no unfavourable effect on performance.
Quantum Random Numbers Generated by a Cloud Superconducting Quantum Computer
Authors: Tamura Kentaro , Shikano Yutaka 
Published: October 2020

AbstractA cloud quantum computer is similar to a random number generator in that its physical mechanism is inaccessible to its users. In this respect, a cloud quantum computer is a black box. In both devices, its users decide the device condition from the output. A framework to achieve this exists in the field of random number generation in the form of statistical tests for random number generators. In the present study, we generated random numbers on a 20-qubit cloud quantum computer and evaluated the condition and stability of its qubits using statistical tests for random number generators. As a result, we observed that some qubits were more biased than others. Statistical tests for random number generators may provide a simple indicator of qubit condition and stability, enabling users to decide for themselves which qubits inside a cloud quantum computer to use.
Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes
Authors: Sun A. , Simsek Papur O. , Dirkx E. , Wong L. , Sips T. , Wang S. , Strzelecka A. , Nabben M. , Glatz J. F. C. , Neumann D. , Luiken J. J. F. P. 
Published: October 2020

AbstractIn the diabetic heart, long-chain fatty acid (LCFA) uptake is increased at the expense of glucose uptake. This metabolic shift ultimately leads to insulin resistance and a reduced cardiac function. Therefore, signaling kinases that mediate glucose uptake without simultaneously stimulating LCFA uptake could be considered attractive anti-diabetic targets. Phosphatidylinositol-4-kinase-IIIβ (PI4KIIIβ) is a lipid kinase downstream of protein kinase D1 (PKD1) that mediates Golgi-to-plasma membrane vesicular trafficking in HeLa-cells. In this study, we evaluated whether PI4KIIIβ is involved in myocellular GLUT4 translocation induced by contraction or oligomycin (an F1F0-ATP synthase inhibitor that activates contraction-like signaling). Pharmacological targeting, with compound MI14, or genetic silencing of PI4KIIIβ inhibited contraction/oligomycin-stimulated GLUT4 translocation and glucose uptake in cardiomyocytes but did not affect CD36 translocation nor LCFA uptake. Addition of the PI4KIIIβ enzymatic reaction product phosphatidylinositol-4-phosphate restored oligomycin-stimulated glucose uptake in the presence of MI14. PI4KIIIβ activation by PKD1 involves Ser294 phosphorylation and altered its localization with unchanged enzymatic activity. Adenoviral PI4KIIIβ overexpression stimulated glucose uptake, but did not activate hypertrophic signaling, indicating that unlike PKD1, PI4KIIIβ is selectively involved in GLUT4 translocation. Finally, PI4KIIIβ overexpression prevented insulin resistance and contractile dysfunction in lipid-overexposed cardiomyocytes. Together, our studies identify PI4KIIIβ as positive and selective regulator of GLUT4 translocation in response to contraction-like signaling, suggesting PI4KIIIβ as a promising target to rescue defective glucose uptake in diabetics.
A new formulation using the Schur complement for the numerical existence proof of solutions to elliptic problems: without direct estimation for an inverse of the linearized operator
Authors: Sekine Kouta , Nakao Mitsuhiro T. , Oishi Shin’ichi 
Published: October 2020

AbstractInfinite-dimensional Newton methods can be effectively used to derive numerical proofs of the existence of solutions to partial differential equations (PDEs). In computer-assisted proofs of PDEs, the original problem is transformed into the infinite-dimensional Newton-type fixed point equation $$w = - {\mathcal {L}}^{-1} {\mathcal {F}}(\hat{u}) + {\mathcal {L}}^{-1} {\mathcal {G}}(w)$$

w
=
-

L

-
1

F

(

u
^

)

+

L

-
1

G

(
w
)

, where $${\mathcal {L}}$$
L
is a linearized operator, $${\mathcal {F}}(\hat{u})$$

F
(

u
^

)

is a residual, and $${\mathcal {G}}(w)$$

G
(
w
)

is a nonlinear term. Therefore, the estimations of $$\Vert {\mathcal {L}}^{-1} {\mathcal {F}}(\hat{u}) \Vert $$

‖

L

-
1

F

(

u
^

)

‖

and $$\Vert {\mathcal {L}}^{-1}{\mathcal {G}}(w) \Vert $$

‖

L

-
1

G

(
w
)

‖

play major roles in the verification procedures . In this paper, using a similar concept to block Gaussian elimination and its corresponding ‘Schur complement’ for matrix problems, we represent the inverse operator $${\mathcal {L}}^{-1}$$

L

-
1

as an infinite-dimensional operator matrix that can be decomposed into two parts: finite-dimensional and infinite-dimensional. This operator matrix yields a new effective realization of the infinite-dimensional Newton method, which enables a more efficient verification procedure compared with existing Nakao’s methods for the solution of elliptic PDEs. We present some numerical examples that confirm the usefulness of the proposed method. Related results obtained from the representation of the operator matrix as $${\mathcal {L}}^{-1}$$

L

-
1

are presented in the “Appendix”.
DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism
Authors: Furukawa Nozomi , Koitabashi Norimichi , Matsui Hiroki , Sunaga Hiroaki , Umbarawan Yogi , Syamsunarno Mas Rizky A. A. , Yamaguchi Aiko , Obokata Masaru , Hanaoka Hirofumi , Yokoyama Tomoyuki , Kurabayashi Masahiko 
Published: October 2020

AbstractDipeptidyl peptidase-4 (DPP-4) inhibitors are widely used incretin-based therapy for the treatment of type 2 diabetes. We investigated the cardioprotective effect of a DPP-4 inhibitor, vildagliptin (vilda), on myocardial metabolism and cardiac performance under pressure overload. Mice were treated with either vehicle orvilda, followed by transverse aortic constriction (TAC). After 3 weeks of TAC, cardiac hypertrophy and impairment of systolic function were attenuated invilda-treated mice. Pressure–volume analysis showed thatvildatreatment significantly improved left-ventricular contractile efficiency in TAC heart. Myocardial energy substrate analysis showed thatvildatreatment significantly increased glucose uptake as well as fatty acid uptake. Fibroblast growth factor 21 (FGF21), a peptide involved in the regulation of energy metabolism, increased in TAC heart and was further increased byvildatreatment. FGF21 was strongly expressed in cardiac fibroblasts than in cardiomyocytes in mouse heart after TAC withvildatreatment.Vildatreatment markedly induced FGF21 expression in human cardiac fibroblasts through a sirtuin (Sirt) 1-mediated pathway, suggesting that fibroblast-mediated FGF21 expression may regulate energy metabolism and exertvilda-mediated beneficial effects in stressed heart.Vildainduced a metabolic regulator, FGF21 expression in cardiac fibroblasts via Sirt1, and increased contractile efficiency in murine pressure-overloaded heart.
Radiological evaluation of a new straight electrode array compared to its precursors
Authors: Ketterer Manuel Christoph , Aschendorff A. , Arndt S. , Speck I. , Rauch A. K. , Beck R. , Hassepass F. 
Published: October 2020

Abstract
Objective
The aim of this study is to examine electrode array coverage, scalar position and dislocation rate in straight electrode arrays with special focus on a new electrode array with 26 mm in lengths.

Study design
Retrospective study.

Setting
Tertiary academic center.

Patients
201 ears implanted between 2013 and 2019.

Main outcome measures
We conducted a comparative analysis of patients implanted with lateral wall electrode arrays of different lengths (F24 = MED-EL Flex24, F26 = MED-EL Flex26, F28 = MED-EL Flex28 and F31.5 = MED-EL FlexSoft). Cone beam computed tomography was used to determine electrode array position (scala tympani (ST) versus scala vestibuli (SV), intracochlear dislocation, position of dislocation and insertion angle).

Results
Study groups show no significant differences regarding cochlear size which excludes influences by cochlear morphology. As expected, the F24 showed significant shorter insertion angles compared to the longer electrode arrays. The F26 electrode array showed no signs of dislocation or SV insertion. The electrode array with the highest rate of ST dislocations was the F31.5 (26.3%). The electrode array with the highest rates of SV insertions was the F28 (5.75%). Most of the included electrode arrays dislocate between 320° and 360° (mean: 346.4°; range from 166° to 502°).

Conclusion
The shorter F24 and the new straight electrode array F26 show less or no signs of scalar dislocation, neither for round window nor for cochleostomy insertion than the longer F28 and the F31.5 array. As expected, the cochlear coverage is increasing with length of the electrode array itself but with growing risk for scalar dislocation and with the highest rates of dislocation for the longest electrode array F31.5. Position of intracochlear dislocation is in the apical cochlear part in the included lateral wall electrode arrays.
Considering additive effects of polypharmacy
Authors: Lexow Monika , Wernecke Kathrin , Schmid Gordian L. , Sultzer Ralf , Bertsche Thilo , Schiek Susanne 
Published: October 2020

Summary
Background
Potential additive effects of polypharmacy are rarely considered in adverse events of geriatric patients living in long-term care facilities. Our aim, therefore, was to identify adverse events in this setting and to assess plausible concomitant drug causes.

Methods
A cross-sectional observational study was performed in three facilities as follows: (i) adverse event identification: we structurally identified adverse events using nurses’ interviews and chart review. (ii) Analysis of the concomitantly administered drugs per patient was performed in two ways: (ii.a) a review of summary of product characteristics for listed adverse drug reactions to identify possible causing drugs and (ii.b) a causality assessment according to Naranjo algorithm.

Results
(i) We found 424 adverse events with a median of 4 per patient (range 1–14) in 103 of the 104 enrolled patients (99%). (ii.a) We identified a median of 3 drugs (range 0–11) with actually occurring adverse events listed as an adverse drug reaction in the summary of product characteristics. (ii.b) Causality was classified in 198 (46.9%) of adverse events as “doubtful,” in 218 (51.2%) as “possible,” in 7 (1.7%) as “probable,” and in 1 (0.2%) adverse event as a “definitive” cause of the administered drugs. In 340 (80.2%) of all identified adverse events several drugs simultaneously reached the highest respective Naranjo score.

Conclusion
Patients in long-term facilities frequently suffer from many adverse events. Concomitantly administered drugs have to be frequently considered as plausible causes for adverse events. These additive effects of drugs should be more focused in patient care and research.
Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas
Authors: Dorfer Christian , Czech Thomas , Gojo Johannes , Hosmann Arthur , Peyrl Andreas , Azizi Amedeo A. , Kasprian Gregor , Dieckmann Karin , Filbin Mariella G. , Haberler Christine , Roessler Karl , Slavc Irene 
Published: October 2020

Abstract
Background
The role of surgery in the management of pediatric non-pilocytic infiltrative thalamic gliomas needs to be revisited specifically with regard to molecularly defined subtypes.

Methods
A retrospective review of a consecutive series of children operated on a thalamic tumor between 1992 and May 2018 was performed. Neuroimaging data were reviewed for localization and extent of resection; pathology was re-reviewed according to the current WHO classification, including assessment of histone H3 K27 mutational status.

Results
Forty-nine patients with a thalamic tumor aged < 18 years at diagnosis were identified. Twenty-five patients (51%) had a non-pilocytic infiltrative glioma, of which the H3 K27M status was available in 22. Fourteen patients were diagnosed as diffuse midline glioma (DMG) H3 K27M mutant. There was no statistically significant difference in survival between patients harboring the H3 K27M mutation and wildtype. Resection (“any resection > 50%” vs “biopsy”) and histological tumor grade (“°II” vs “°III+°IV”) were statistically significant predictors of survival (univariate: p = 0.044 and p = 0.013, respectively). These results remained significant on multivariate analysis (HR 0.371/p = 0.048, HR 9.433/p = 0.035).

Conclusion
We advocate to still consider an attempt at maximal safe resection in the multidisciplinary treatment of unilateral thalamic non-pilocytic gliomas irrespective of their H3 K27-mutational status.
Relationships between cystatin C- and creatinine-based eGFR in Japanese rural community- dwelling older adults with sarcopenia
Authors: Kusunoki Hiroshi , Tsuji Shotaro , Kusukawa Tomoyuki , Wada Yosuke , Tamaki Kayoko , Nagai Koutatsu , Itoh Masako , Sano Kyoko , Amano Manabu , Maeda Hatsuo , Sugita Hideyuki , Hasegawa Yoko , Kishimoto Hiromitsu , Shimomura Soji , Shinmura Ken 
Published: October 2020

Abstract
Background
Sarcopenia is prevalent in patients with chronic kidney disease (CKD). The indices of physical function, such as grip power and gait speed, decreased according to the decline in the estimated glomerular filtration rate (eGFR).

Methods
We examined the relationships between cystatin C-based GFR (eGFRcys), creatinine-based GFR (eGFRcre), their ratio (eGFRcys/eGFRcre) and sarcopenia in community-dwelling older adults in Japan. This cross-sectional study included 302 men aged 73.9 ± 6.2 years and 647 women aged 72.9 ± 5.8 years from a rural area in Hyogo Prefecture, Japan. eGFRcys and eGFRcre were simultaneously measured, and sarcopenia based on the Asia Working Group for Sarcopenia (AWGS) 2019 criteria was evaluated.

Results
eGFRcys and the eGFRcys/eGFRcre ratio were significantly correlated with grip power and gait speed (p < 0.001). The eGFRcys/eGFRcre ratio was also correlated with skeletal muscle mass index (SMI) (p < 0.01). Univariate logistic regression analysis showed eGFRcys and eGFRcys/eGFRcre ratio but not eGFRcre were associated with sarcopenia (p < 0.01). The presence of low eGFRcys (CKDcys) and low eGFRcys/eGFRcre ratio (< 1.0) but not that of low eGFRcre (CKDcre) were associated with sarcopenia (p < 0.01). In the multivariate logistic regression analysis, when the eGFRcys/eGFRcre ratio was added as a covariate to the basic model, it was significantly associated with sarcopenia in women (p < 0.05). Moreover, low eGFRcys/eGFRcre ratio (< 1.0) was associated with a higher risk of sarcopenia in men (p < 0.01).

Conclusion
In conclusion, CKDcys but not CKDcre is associated with sarcopenia. A lower eGFRcys/eGFRcre ratio may be a practical screening marker of sarcopenia in community-dwelling older adults.
Engineering of a thermo-alkali-stable lipase from Rhizopus chinensis by rational design of a buried disulfide bond and combinatorial mutagenesis
Authors: Wang Rui , Wang Shang , Xu Yan , Yu Xiaowei 
Published: October 2020

Abstract
To improve the thermostability of the lipase (r27RCL) from Rhizopus chinensis through rational design, a newly introduced buried disulfide bond F223C/G247C was proved to be beneficial to thermostability. Interestingly, F223C/G247C was also found to improve the alkali tolerance of the lipase. Subsequently, six other thermostabilizing mutations from our previous work were integrated into the mutant F223C/G247C, leading to a thermo-alkali-stable mutant m32. Compared to the wild-type lipase, the associative effect of the beneficial mutations showed significant improvements on the thermostability of m32, with a 74.7-fold increase in half-life at 60 °C, a 21.2 °C higher T5030\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_{50}^{30}$$\end{document} value and a 10 °C elevation in optimum temperature. The mutated m32 was also found stable at pH 9.0–10.0. Furthermore, the molecular dynamics simulations of m32 indicated that its rigidity was enhanced due to the decreased solvent-accessible surface area, a newly formed salt bridge, and the increased ΔΔG values.
Doing Good by Doing Bad: How Tone at the Top and Tone at the Bottom Impact Performance-Improving Noncompliant Behavior
Authors: Ewelt-Knauer Corinna , Schwering Anja , Winkelmann Sandra 
Published: October 2020

AbstractThis study investigates how tone at the top, implemented by top management, and tone at the bottom, in an employee’s immediate work environment, determine noncompliance. We focus on the disallowed actions of employees that improve their own and, in turn, the company’s performance, referred to as performance-improving noncompliant behavior (PINC behavior). We conduct a survey of German sales employees to investigate specifically how, on the one hand, (1) corporate rules and (2) performance pressure, both implemented by top management, and, on the other hand, (3) others’ PINC expectations and (4) others’ PINC behavior, both arising from the employee’s immediate work environment, influence PINC behavior. When considered in isolation, we find that corporate rules, as top management’s main instrument to guide employee behavior, decrease employee PINC behavior. However, this effect is negatively influenced by the employees’ immediate work environment when employees are expected to engage in PINC or when others engage in PINC. In contrast, even though top management places great performance pressure on employees, that by itself does not increase PINC behavior. Overall, our study informs practitioners and researchers about whether and how the four determinants increase or decrease employees’ PINC behavior, which is important to comprehend triggers and to counteract such misconduct.
Phase I study assessing the mass balance, pharmacokinetics, and excretion of [14C]-pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors
Authors: Zhou Xiaofei , Sedarati Farhad , Faller Douglas V. , Zhao Dan , Faessel Hélène M. , Chowdhury Swapan , Bolleddula Jayaprakasam , Li Yuexian , Venkatakrishnan Karthik , Papai Zsuzsanna 
Published: October 2020

SummaryPevonedistat (TAK-924/MLN4924) is an investigational small-molecule inhibitor of the NEDD8-activating enzyme that has demonstrated preclinical and clinical activity across solid tumors and hematological malignancies. Here we report the results of a phase I trial characterizing the mass balance, pharmacokinetics, and clearance pathways of [14C]-pevonedistat in patients with advanced solid tumors (NCT03057366). In part A (n = 8), patients received a single 1-h intravenous infusion of [14C]-pevonedistat 25 mg/m2. In part B (n = 7), patients received pevonedistat 25 or 20 mg/m2 on days 1, 3, and 5 in combination with, respectively, docetaxel 75 mg/m2 or carboplatin AUC5 plus paclitaxel 175 mg/m2 on day 1 every 3 weeks. Following the single dose of [14C]-pevonedistat 25 mg/m2 in part A, there was a parallel log-linear decline in plasma and whole blood pevonedistat concentration, with systemic exposure of unchanged pevonedistat representing 41% of drug-related material (i.e., unchanged pevonedistat and its metabolites). The mean terminal half-life of pevonedistat and drug-related material in plasma was 8.4 and 15.6 h, respectively. Pevonedistat distributed preferentially in whole blood with a mean whole-blood-to-plasma ratio for pevonedistat AUC∞ of 40.8. By 1 week post dose, the mean recovery of administered radioactivity was 94% (41% in urine and 53% in feces). The pevonedistat safety profile during both study parts was consistent with previous clinical experience, with no new safety signals observed. In part B, pevonedistat in combination with docetaxel or carboplatin plus paclitaxel was generally well tolerated. ClinicalTrials.gov identifier: NCT03057366.
Implicit max-stable extremal integrals
Authors: Kremer D. 
Published: October 2020

AbstractRecently, the notion of implicit extreme value distributions has been established, which is based on a given loss function f ≥ 0. From an application point of view, one is rather interested in extreme loss events that occur relative to f than in the corresponding extreme values itself. In this context, so-called f -implicit α-Fréchet max-stable distributions arise and have been used to construct independently scattered sup-measures that possess such margins. In this paper we solve an open problem in Goldbach (2016) by developing a stochastic integral of a deterministic function g ≥ 0 with respect to implicit max-stable sup-measures. The resulting theory covers the construction of max-stable extremal integrals (see Stoev and Taqqu Extremes 8, 237–266 (2005)) and, at the same time, reveals striking parallels.
Variable Smoothing for Convex Optimization Problems Using Stochastic Gradients
Authors: Boţ Radu Ioan , Böhm Axel 
Published: October 2020

AbstractWe aim to solve a structured convex optimization problem, where a nonsmooth function is composed with a linear operator. When opting for full splitting schemes, usually, primal–dual type methods are employed as they are effective and also well studied. However, under the additional assumption of Lipschitz continuity of the nonsmooth function which is composed with the linear operator we can derive novel algorithms through regularization via the Moreau envelope. Furthermore, we tackle large scale problems by means of stochastic oracle calls, very similar to stochastic gradient techniques. Applications to total variational denoising and deblurring, and matrix factorization are provided.
On the General Properties of Non-linear Optical Conductivities
Authors: Watanabe Haruki , Liu Yankang , Oshikawa Masaki 
Published: October 2020

AbstractThe optical conductivity is the basic defining property of materials characterizing the current response toward time-dependent electric fields. In this work, following the approach of Kubo’s response theory, we study the general properties of the nonlinear optical conductivities of quantum many-body systems both in equilibrium and non-equilibrium. We obtain an expression of the second- and the third-order optical conductivity in terms of correlation functions and present a perturbative proof of the generalized Kohn formula proposed recently. We also discuss a generalization of the f-sum rule to a non-equilibrium setting by focusing on the instantaneous response.