bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Outcomes of Newly Diagnosed T Lymphoblastic Lymphoma: Results From Children’s Oncology Group AALL0434
Authors: Hayashi Robert J. , Winter Stuart S. , Dunsmore Kimberly P. , Devidas Meenakshi , Chen Zhiguo , Wood Brent L. , Hermiston Michelle L. , Teachey David T. , Perkins Sherrie L. , Miles Rodney R. , Raetz Elizabeth A. , Loh Mignon L. , Winick Naomi J. , Carroll William L. , Hunger Stephen P. , Lim Megan S. , Gross Thomas G. , Bollard Catherine M. 
Published: June 2020

PURPOSE The Children’s Oncology Group (COG) protocol AALL0434 evaluated the safety and efficacy of multi-agent chemotherapy with Capizzi-based methotrexate/pegaspargase (C-MTX) in patients with newly diagnosed pediatric T-cell lymphoblastic lymphoma (T-LL) and gained preliminary data using nelarabine in high-risk patients. PATIENTS AND METHODS The trial enrolled 299 patients, age 1-31 years. High-risk (HR) patients had ≥ 1% minimal detectable disease (MDD) in the bone marrow at diagnosis or received prior steroid treatment. Induction failure was defined as failure to achieve a partial response (PR) by the end of the 4-week induction. All patients received the augmented Berlin-Frankfurt-Muenster (ABFM) C-MTX regimen. HR patients were randomly assigned to receive or not receive 6 5-day courses of nelarabine incorporated into ABFM. Patients with induction failure were nonrandomly assigned to ABFM C-MTX plus nelarabine. No patients received prophylactic cranial radiation; however, patients with CNS3 disease (CSF WBC ≥ 5/μL with blasts or cranial nerve palsies, brain/eye involvement, or hypothalamic syndrome) were ineligible. RESULTS At end-induction, 98.8% of evaluable participants had at least a PR. The 4-year event-free survival (EFS) and overall survival (OS) were 84.7% ± 2.3% and 89.0% ± 2.0%. The 4-year disease-free survival (DFS) from end-induction was 85.9% ± 2.6%. There was no difference in DFS observed between the HR and standard-risk groups ( P = .29) or by treatment regimen ( P = .55). Disease stage, tumor response, and MDD at diagnosis did not demonstrate thresholds that resulted in differences in EFS. Nelarabine did not show an advantage for HR patients. CNS relapse occurred in only 4 patients. CONCLUSION COG AALL0434 produced excellent outcomes in one of the largest trials ever conducted for patients with newly diagnosed T-LL. The COG ABFM regimen with C-MTX provided excellent EFS and OS without cranial radiation.
Biomimetic device and foreign body reaction cooperate for efficient tumour cell capture in murine advanced ovarian cancer
Authors: Alonso-Alconada Lorena , de la Fuente Alexandre , Santacana María , Ferreiros Alba , Lopez-Lopez Rafael , Matias-Guiu Xavier , Abal Miguel 
Published: June 2020

ABSTRACT
Metastasis is facilitated by the formation of pre-metastatic niches through the remodelling of the extracellular matrix (ECM) promoted by haematopoietic and stromal cells. The impact of these primed sites is pronounced for intraperitoneal metastases, where the cavity-exposed ECM supports the attachment of the disseminating tumour cells. Likewise, implantation of biomaterial scaffolds influences metastatic progression systemically through a foreign body reaction (FBR). In this study, we integrated the concept of creating an artificial niche to capture tumour cells actively disseminating in the peritoneal cavity with a therapeutic strategy modulating the interactions of metastatic cells with the ECM. The aim was to transform a disseminated disease into a focal disease. For this, we designed and developed a ‘biomimetic’ ECM composed of a nonresorbable three-dimensional scaffold with collagen coating and characterized the FBR to the implanted biomaterial. We also analysed the safety of the implanted devices and their ability to capture tumour cells in different murine preclinical models of advanced ovarian cancer. Implantation of the biomimetic devices resulted in an initial inflammatory reaction that transformed progressively into a fibrous connective tissue response. The adhesive capabilities of the scaffold were improved with the ancillary effect of the FBR and showed clinical utility in terms of the efficacy of capture of tumour cells, disease focalization and survival benefit. These results demonstrated the performance and safety of this ‘biomimetic’ ECM in preclinical models of advanced ovarian cancer. Translated into the clinical setting, this new therapeutic strategy represents the possibility for control of peritoneal carcinomatosis upon primary ovarian debulking surgery and to expand the percentage of patients who are candidates for second rescue surgeries at the time of relapse.
Community of Aquatic Macroinvertebrates in an Atlantic Forest Stream, Brazil
Authors: Azevedo Rafael Santos de , Dumas Leandro , Rodrigues Daniela , Rezende Carla Ferreira , Caramaschi Érica Pellegrini , Mazzoni Rosana , Nessimian Jorge 
Published: June 2020

Composition, diversity and density of benthic macroinvertebrates were described based on samples from the four different sites of Rio Mato Grosso, Saquarema, Rio de Janeiro. Biotic and environmental data were obtained in January 2006 in microhabitats with different substrates. A total of 5.605 specimens of the 28 insect families and two crustaceous families are sampled. The lowest values of richness, diversity, equitability and density were observed in low altitude sites. The highest diversity and density values were observed in litter substrate, while sand substrate showed lower values of these parameters.
Estrutura da Comunidade de Macroinvertebrados Aquáticos de um Riacho de Mata Atlântica, Brasil
Resumo. A composição, diversidade e densidade de macroinvertebrados bentônicos foram descritas a partir de amostras provenientes de quatro localidades distintas do Rio Mato Grosso, Saquarema, Rio de Janeiro. Os dados bióticos e abióticos foram obtidos em janeiro 2006 em microhabitats com diferentes tipos de substrato. Foi amostrado um total de 5.605 espécimes de 28 famílias de insetos e duas de crustáceos. Os menores valores de riqueza, diversidade, equitabilidade e densidade foram registrados nas localidades de menor altitude. Folhiço foi o substrato com maiores valores de diversidade e densidade, enquanto areia apresentou os menores valores desses parâmetros.
Fauna de Coleoptera Associada a Carcaças de Coelhos Expostas em uma Área Urbana no Sul do Brasil
Authors: Silva Richard Cordeiro da , Santos Wellington Emanuel dos 
Published: June 2020

Estudo da fauna de Coleoptera associada a carcaças de coelhos, Oryctolagus cuniculus Linnaeus (Lagomorpha, Leporidae), durante o verão de 2010 e o inverno de 2011, em uma área urbana do norte do Paraná, sul do Brasil, é apresentado. Para captura dos coleópteros foram utilizadas armadilhas do tipo bandeja, pitfall e Shannon modificada. Foram coletados 236 coleópteros pertencentes a 12 famílias e pelo menos 25 espécies. Staphylinidae (52,5%) e Histeridae (26,7%) foram as famílias mais abundantes em ambas as estações, representadas principalmente por Aleochara bonariensis Lynch e Euspilotus “grupo” azureus sp., respectivamente. Entre as estações, tanto a decomposição das carcaças quanto a sucessão da coleopterofauna de interesse forense ocorreram de forma distinta, devido à variação expressiva dos fatores abióticos. Durante o inverno, a maioria dos indivíduos de Euspilotus "grupo" azureus sp. (96,8%) foi capturada no estágio de Putrefação Escura, revelando uma associação a esse estágio. Apesar da sazonalidade do ambiente, não houve diferença significativa da abundância dos coleópteros mais coletados, nem da coleopterofauna em geral, entre as estações.
Coleoptera Fauna Associated with Rabbit Carcasses Exposed in an Urban Area in Southern Brazil
Abstract. Study of Coleoptera fauna associated with rabbit carcasses, Oryctolagus cuniculus Linnaeus (Lagomorpha, Leporidae), during the summer of 2010 and winter of 2011, is present at an urban area of Northern Paraná State, Southern Brazil. To capture the beetles were used pan, pitfall and modified Shannon traps. We collected 236 beetles belonging to 12 families and at least 25 species. Staphylinidae (52.5%) and Histeridae (26.7%) were the most abundant families in both seasons represented mainly by Aleochara bonariensis Lynch and Euspilotus "group" azureus sp., respectively. Among the seasons, both the decomposition of the carcasses and the succession of coleopterofauna of forensic interest occurred differently due to significant variation of abiotic factors. During the winter, most individuals of Euspilotus "group" azureus sp. (96.8%) was captured at the stage of Black Putrefaction, showing an association at this stage. Despite the environment seasonality, there wasn’t significant difference of the abundance among seasons by main beetles neither by coleopterofauna.
Training of Engineering Personnel for Working in Agriculture Considering the Requirements for Digitalization Development in Agro – Industrial Complex
Authors: RUBAEVA O. D. , ZUBAREVA I. A. , PAKHOMOVA N. A. , MALYKHINA E. A. 
Published: June 2020

This article describes the impact of digital economy on changes in economic environmental and social spheres. This leads to changes in educational environment considering the requirements for the development of digitalization in agro – industrial complex (AIC). In this regard, the conditions of education and training of engineering personnel with competencies for working in AIC digital economy are also changing.
The authors studied influence of the main trends in the development of digital fluency and digital competencies on the formation of engineering human resources in AIC. Particular attention was paid to the analysis of the development of the human resources component of the digital economy of AIC in this region, in particular, according to the parameters of “Personnel for Digital Economy” project in the Chelyabinsk Region, it is planned to increase the share of population with digital fluency and key competencies in digital economy from 27% in 2019 to 80% by year 2024.
Human resources are the most important strategic resource for the development of AIC digitalization. At the same time, labor requirements are constantly growing. Formation of digital competencies should be the goal of engineers, and the development of a mechanism to achieve this goal is the main task of state personnel policy, science and education. Consequently, the role of education in training of engineering personnel for working in agriculture taking into account the requirements for AIC digitalization development is becoming more and more relevant.
Discourse on Relations Between Indonesia and Papua: Content Analysis of History Textbook of 2013 Curriculum
Authors: Handoko Susanto T , Wasino Wasino 
Published: June 2020

This research is motivated by the existence of a national identity crisis in Indonesian society, especially in young people or students. This research aims to analyze the discourse on relations between Indonesia and Papua found in a history textbook for senior high school of 2013 curriculum. Through this research, an understanding of how the state reconstructs national identity (Indonesian-ness) and local identity (Papuan-ness) in a history textbook for senior high school used by senior high school students in Jayapura City. The research method used is the qualitative method, which focuses on the content analysis of the history textbook. This analysis will focus on the relations between Indonesia and Papua. The meaning process was conducted using two concepts, namely Indonesian-ness and Papuan-ness. Then, those two concepts were represented in three themes: ethnic nationalism, nationalism, and national integration. The results of the research showed that the discourse on national identity (Indonesian-ness) and local identity (Papuan-ness) was a product of the government’s political policies in education, namely ideology and state identity. Penelitian ini dilatarbelakangi oleh adanya krisis identitas nasional di masyarakat Indonesia, terutama pada kaum muda atau pelajar. Penelitian ini bertujuan untuk menganalisis wacana tentang hubungan Indonesia dan Papua yang ditemukan dalam buku teks sejarah untuk kurikulum SMA 2013. Melalui penelitian ini, pemahaman tentang bagaimana negara merekonstruksi identitas nasional dan identitas lokal dalam buku teks sejarah untuk SMA yang digunakan oleh siswa SMA di Kota Jayapura. Metode penelitian yang digunakan adalah metode kualitatif, yang berfokus pada analisis isi buku teks sejarah. Analisis ini akan fokus pada hubungan antara Indonesia dan Papua. Proses pemaknaan dilakukan dengan menggunakan dua konsep, yaitu keindonesiaan dan ke-Papua-an. Kemudian, kedua konsep tersebut diwakili dalam tiga tema: nasionalisme etnis, nasionalisme, dan integrasi nasional. Hasil penelitian menunjukkan bahwa wacana tentang identitas nasional dan identitas lokal adalah produk kebijakan politik pemerintah dalam pendidikan, yaitu ideologi dan identitas negara.
Missing the boat: fatal ending to a missed case of Charcot arthropathy
Authors: Galeazzi Rech Anna Luiza , Stüve Yvon , Toepfer Andreas , Schimke Katrin E 
Published: June 2020

Summary
Acute Charcot neuropathic osteoarthropathy (CN) is a clinical entity which can easily go unrecognized in its acute early stages due to lack of awareness and unspecific presentation. However, missing early diagnosis can lead to severe complications. We present the case of a 72-year-old male patient who went through the natural course of the disease unnoticed before the very eyes of his physicians leading to a tragic end. We aim to raise awareness for this rare diabetic complication, emphasizing the necessity of early diagnosis and adequate, interdisciplinary treatment.

Learning points:

Clinical signs and symptoms of acute Charcot neuropathic osteoarthropathy (CN).

Red flags.

Importance of early diagnosis and correct treatment.

Diagnostic challenges of acute CN.

Awareness of high morbidity and mortality.
IMPLEMENTASI NILAI-NILAI KEARIFAN LOKAL AWIK-AWIK DESA SESAOT DALAM PEMBELAJARAN ILMU PENGETAHUAN SOSIAL
Authors: Irrubai Mohammad Liwa 
Published: June 2020

AbstractThis paper describes the implementation of local wisdom values awik-awik Sesaot Village, Narmada District, West Lombok, West Nusa Tenggara in social studies learning. The method used in this research is classroom action research. The results showed that the values of the awik-awik Sesaot Village were local wisdom derived from the bragging (proverb) and customs that apply to the people of Sesaot Village to protect and preserve the environment. The values of local wisdom referred to are as follows. First, aiq meneng, tunjung tilah, empaq bau (water remains clear, lotus remains intact, fish is obtained). Second, besesiru (coopeation). Third, bau besi, bau asaq (get iron, also get asaq). Fourth, ndaq tame gawah laun ketemuq sig jin (don't enter the forest carelessly disturbed by jinn). Fifth, daq bait doen dengan laun cekok (don't take other people's things later, bend their hands). Implementation of awik-awik values in social studies learning can build student character related to democratic values practiced by making simple rules at school, values of environmental care practiced by planting trees, as well as honesty values that are practiced by opening an honest canteen. Keywords: Local Wisdom, Awak-awik Sesaot Village, Social Studies Learning. ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan nilai-nilai pada kearifan lokal awik-awik Desa Sesaot, Kecamatan Narmada, Lombok Barat, Nusa Tenggara Barat dan konten / materi, pelaksanaan nilai-nilai yang terkandung dalam kearifan lokal Awik-awik Desa Sesaot. Metode penelitian yaitu penelitian kualitatif dengan class action research. Hasil dari penelitian ini menunjukkan bahwa nilai-nilaiawik-awik Desa Sesaot merupakan kearifan lokal yang berasal dari sesenggak/pribahasa dan kebiasaan yang hidup pada masyarakat Desa sesaot untuk menjaga dan melestarikan lingkungan dan hutan mereka. Adapun nilai-nilai dari awik-awik Desa Sesaot sebagai berikut: a) Aiq meneng, tunjung tilah, empaq bau, air/tetap jernih teratai/tetap utuh, ikanpun di dapat/tertangkap, b)Besesiru/besiru(tolong-menolong), c) Bau Besi, Bau Asaq. (Besi dapat, asahpun dapat), d)Ndaq tame gawah laun ketemuq siq jin(jangan masuk hutan sembarangan nanti diganggu oleh jin), e) Ndaq bait doen dengan laun cekok (jangan ambil barang orang lain nanti bengkok tangannya). Pada tingkat implementasi nilai-nilai awik-awik dalam pembelajaran IPS telah mampu membangun karakter siswa setelah proses pembelajaran dan praktik lapangan, yakninilai demokrasi dipraktikkan dengan membuat peraturan sederhana di sekolah, nilai peduli lingkungan dipraktikkan dengan menanam pohon dan nilai jujur dipraktikkan dengan kantin kejujuran. Keywords: Kearifan Lokal, Awik-awik Desa Sesaot, Pembelajaran IPS
Awareness of and intention to use an online sexually transmitted and blood-borne infection testing service among gay and bisexual men in British Columbia, two years after implementation
Authors: Dulai Joshun , Salway Travis , Thomson Kimberly , Haag Devon , Lachowsky Nathan , Grace Daniel , Edward Joshua , Grennan Troy , Trussler Terry , Gilbert Mark 
Published: June 2020

Abstract
Objectives
This study assessed gay, bisexual, and other men who have sex with men’s (GBMSM) awareness of and intention to use GetCheckedOnline, an online sexually transmitted and blood-borne infection (STBBI) testing service.

Methods
A cross-sectional study was conducted two years after launch among GBMSM > 18 years of age in British Columbia, Canada. Participants were recruited through community venues, clinics, websites, and apps.

Results
Of 1272 participants, 32% were aware of GetCheckedOnline. Gay identity, regularly testing at an STBBI clinic, being out to one’s healthcare provider, attending GBMSM community venues, and frequent social media use were associated with awareness. Among participants who were aware but had not used GetCheckedOnline, knowing GetCheckedOnline users, using social media, not knowing where else to test, and not wanting to see a doctor were associated with intention to use GetCheckedOnline.

Conclusion
Early promotion of GetCheckedOnline resulted in greater awareness among those connected to GBMSM.
Kształtowanie wizerunku wybranych grup dyspozycyjnych
Authors: Klein Grzegorz 
Published: June 2020

Badania zrekapitulowane w niniejszym artykule poświęcono identyfikacji korzyści wynikają-cych z posiadania przez wybrane grupy dyspozycyjne dobrego wizerunku. Przyjęto, że dla Wojska Polskiego, Policji i Państwowej Straży Pożarnej można sformułować katalog tożsamych wizerunko-wych korzyści ułatwiających zapewnianie bezpieczeństwa. W celu weryfikacji tego założenia prze-prowadzono analizę użyteczności dobrego wizerunku dla wybranych grup dyspozycyjnych, następ-nie dokonano syntezy wyodrębnionych elementów.
Na podstawie przeprowadzonych badań przyjęto, że opracowany katalog wizerunkowych ko-rzyści może być użytecznym narzędziem w zakresie badania kształtowania wizerunku oraz rela-cji ze społeczeństwem zarówno wyodrębnionych na użytek tego badania Wojska Polskiego, Policji i Państwowej Straży Pożarnej, jak i innych grup dyspozycyjnych.
Od wspomożyciela do wroga — o doświadczeniach współpracy z policją z perspektywy rodzin osób zaginionych długotrwale
Authors: Urbaniak Aneta 
Published: June 2020

Celem artykułu jest opis jakości współpracy pomiędzy Policją a bliskimi osób zaginionych. Współpraca ta rozpoczyna się od ustanowienia wspólnego celu, jakim jest odnalezienie osoby zagi-nionej. W kontekście badań własnych autorki artykuł omawia zidentyfikowane uprzednio kontro-wersje dotyczące jakości formalnego systemu poszukiwań osób zaginionych. Wykorzystany materiał empiryczny pochodzi z wywiadów narracyjnych. W artykule przedstawiono jedynie perspektywę rodzin osób zaginionych. Zidentyfikowano i omówiono trzy podstawowe problemy dotyczące jako-ści współpracy pomiędzy tymi podmiotami.
Diagnoza potrzeb edukacyjnych w zakresie bezpieczeństwa osobistego w percepcji uczniów szkół podstawowych na przykładzie miasta powiatowego
Authors: Pychner Małgorzata 
Published: June 2020

W niniejszym referacie zaprezentowano wyniki badań ankietowych mających na celu zidentyfikowa-nie potrzeb i oczekiwań uczniów szkół podstawowych i gimnazjów wobec edukacji dla bezpieczeństwa. Przystępując do realizacji badań, punktem wyjścia uczyniono stwierdzenie, że aby skutecznie oddziały-wać na młodzież w zakresie bezpiecznych zachowań, należy dokonywać analizy zagrożeń charaktery-stycznych dla regionu, jak również diagnozować potrzeby samych odbiorców. Badaniami objęto grupę
uczniów z trzech szkół znajdujących się na terenie Garwolina — jednego z miast powiatowych w wo-jewództwie mazowieckim. Ich celem było zdefiniowanie oczekiwań edukacyjnych młodzieży w kwestii bezpieczeństwa personalnego ograniczonego do zagrożeń związanych z przestępczością i patologiami społecznymi, które mogą stanowić podstawę do implementacji wskazywanych przez respondentów kwe-stii w działania szkół i instytucji realizujących zadania na rzecz bezpieczeństwa w regionie.
THE ROLE OF "PAGUYUBAN REMAJA PEDULI AIDS SIDOARJO" (PARPAS) ON KNOWLEDGE, ATTITUDE, AND ACTION FOR HIV/AIDS PREVENTION IN SENIOR HIGH SCHOOLS IN SIDOARJO
Authors: Pratiwi Adelia Dwi , Purnomo Windhu 
Published: June 2020

There were total of 2,100,000 new HIV infections worldwide and 1,500,000 deaths from AIDS recorded in 2013. The total HIV/AIDS cases in 2017 in Sidoarjo reached 476 cases and cumulatively reached 1,245 cases. HIV/AIDS is a well-known topic among teenagers. Teenagers are often associated with physical development in puberty phase which usually followed by sexual development. Furthermore, they also experience changes emotionally and physically which are projected in their behavior and attitude. These circumstances make teenagers prone to the risky behavior towards HIV/AIDS transmission. This study aims to analyze the role of "Paguyuban Peduli HIV/AIDS Sidoarjo" or PARPAS on teenagers' knowledge, attitude, and behavior towards HIV/AIDS prevention. This research is an observational analytic using cross-sectional research design. The population of the study is all students of SMAN 1 Taman and SMAN 1 Sidoarjo, 2,370 students in total. The sampling technique uses simple random sampling and the sample size is 100 students. The result shows that there is correlation between PARPAS role on knowledge and attitude of students' in Sidoarjo towards HIV/AIDS prevention. Nevertheless, there is no correlation between PARPAS role on students' behavior towards HIV/AIDS prevention. Suggestions concluded from the results are including early detection, attempt in joining organization related to HIV/AIDS awareness, and health education given to both students and parents.