bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Biomimetic 3D‐Self‐Forming Approach for Microvascular Scaffolds
Authors: Zhang Liucheng , Xiang Yi , Zhang Hongbo , Cheng Liying , Mao Xiyuan , An Ning , Zhang Lu , Zhou Jinxiong , Deng Lianfu , Zhang Yuguang , Sun Xiaoming , Santos Hélder A. , Cui Wenguo 
Published: March 2020

AbstractThe development of science and technology often drew lessons from natural phenomena. Herein, inspired by drying‐driven curling of apple peels, hydrogel‐based micro‐scaled hollow tubules (MHTs) are proposed for biomimicking microvessels, which promote microcirculation and improve the survival of random skin flaps. MHTs with various pipeline structures are fabricated using hydrogel in corresponding shapes, such as Y‐branches, anastomosis rings, and triangle loops. Adjustable diameters can be achieved by altering the concentration and cross‐linking time of the hydrogel. Based on this rationale, biomimetic microvessels with diameters of 50–500 µm are cultivated in vitro by coculture of MHTs and human umbilical vein endothelial cells. In vivo studies show their excellent performance to promote microcirculation and improve the survival of random skin flaps. In conclusion, the present work proposes and validifies a biomimetic 3D self‐forming method for the fabrication of biomimetic vessels and microvascular scaffolds with high biocompatibility and stability based on hydrogel materials, such as gelatin and hyaluronic acid.
Carbohydrate antigen 19‐9‐producing gastric carcinoma: A case report
Authors: Huang Pi‐Teh , Lin Lien‐Fu 
Published: March 2020

AbstractCarbohydrate antigen 19‐9 (CA 19‐9) is a tumor marker often elevated in pancreatic and hepatobiliary malignancies. CA 19‐9 has also been rarely reported to be a marker of digestive tract malignancies. We report a case of CA 19‐9‐producing gastric cancer with a markedly high serum CA 19‐9 level (52 862 U/mL). Immunohistochemical staining of the biopsy specimen was positive for CA 19‐9. Patient received palliative chemotherapy but expired due to disease progression. Elevated CA 19‐9 in gastric cancer is relatively rare and is correlated with poor prognosis.
Genetic relationships and polyploid origins in the Lippia alba complex
Authors: Lopes Juliana M. L. , de Carvalho Humberto Henrique , Zorzatto Cristiane , Azevedo Ana Luisa S. , Machado Marco Antonio , Salimena Fátima Regina G. , Grazul Richard M. , Gitzendanner Matthew A. , Soltis Douglas E. , Soltis Pamela S. , Viccini Lyderson F. 
Published: March 2020

PremisePlant genomes vary in size and complexity due in part to polyploidization. Latitudinal analyses of polyploidy are biased toward floras of temperate regions, with much less research done in the tropics. Lippia alba has been described as a tropical polyploid complex with diploid, triploid, tetraploid, and hexaploid accessions. However, no data regarding relationships among the ploidal levels and their origins have been reported. Our goals are to clarify the relationships among accessions of Lippia alba and the origins of each ploidal level.MethodsWe investigated 98 samples representing all five geographical regions of Brazil and all ploidal levels using microsatellite (SSR) allelic variation and DNA sequences of ITS and trnL‐F. Nine morphological structures were analyzed from 33 herbarium samples, and the chemical compounds of 78 accessions were analyzed by GC–MS.ResultsGenetic distance analysis, the alignment block pattern, as well as RAxML and Bayesian trees showed that accessions grouped by ploidal level. The triploids form a well‐defined group that originated from a single group of diploids. The tetraploids and hexaploid grouped together in SSR and trnL‐F analyses. The recovered groups agree with chemical data and morphology.ConclusionsThe accessions grouped by ploidal level. Only one origin of triploids from a single group of diploids was observed. The tetraploid origin is uncertain; however, it appears to have contributed to the origin of the hexaploid. This framework reveals linkages among the ploidal levels, providing new insights into the evolution of a polyploid complex of tropical plants.
Congenital limb reduction defects in 1.6 million births in Argentina
Authors: Alberto Guillermo , Barbero Pablo , Liascovich Rosa , Bidondo María Paz , Groisman Boris 
Published: February 2020

AbstractThe objectives of this study were to describe the birth prevalence of limb reduction defects (LRD) in Argentina, their clinical features, and to review the literature on this topic. The data source was the National Network of Congenital Anomalies of Argentina, a surveillance system that has been operative since 2009. Data were collected from November 1, 2009 to December 31, 2016. 1,663,610 births and 702 affected patients were registered during this period. The prevalence of LRD was 4.22/10,000 births (CI 95%: 3.93–4.54). In 15,094 stillbirths, prevalence was 30.80/10,000 (CI 95%: 22.31–40.65). Perinatal mortality (stillbirths plus early neonatal deaths) was 24.6%, mostly explained by postnatal deaths. LRD were classified according to different variables, including Gold's anatomic classification. Then, 41.0% of patients had transverse terminal defects and 50.2% had longitudinal defects. We found multiple and syndromic clinical presentation to be associated with both preaxial LRD and lethality. The prevalence of LRD was lower and perinatal mortality was higher in our study compared to that of previously published studies. Because there is heterogeneity in the inclusion and exclusion criteria among publications, a greater effort should be made in order to include similar populations and to use a unified anatomic classification and nomenclature.
Loss and grief: The experience of transition to residential aged care
Authors: Zizzo Gabriella , Mackenzie Catherine , Irizarry Carol , Goodwin‐Smith Ian 
Published: March 2020

AbstractThere is growing recognition of the experience of non‐death‐related loss and grief. One unexplored area of non‐death‐related loss and grief is associated with older people’s transition from home to residential aged care (RAC). This paper reports findings from a qualitative study that explored the experiences of people living in RAC, carer‐relatives of people living in RAC and RAC staff. Using theories of loss and grief, the paper identifies features of the transition to RAC that are associated with unresolved loss and maladaptation to changed circumstances, and the types of support that would mitigate these. Using a series of focus groups with both residents and carer‐relatives, as well as staff, the study found that residents and their families need more support to negotiate the multiple, often necessarily hasty decisions and bureaucratic requirements associated with transitioning to RAC, while simultaneously experiencing loss and grief. The types of support that families would welcome from service providers include facilitating shared decision making, valuing family and community carer expertise and providing practical information and assistance to fulfil administrative obligations.
Principles of coaxial illumination for photochemical reactions: Part 2. Model validation
Authors: Meir Glen , Leblebici Mumin Enis , Kuhn Simon , Van Gerven Tom 
Published: February 2020

AbstractThis study reports the principles and model equations for co‐ and counter‐current illumination, validated by experimental data. Current photochemical reactors which are homogeneously illuminated suffer from a light efficiency problem resulting in low light absorption and subsequent low productivity. Hence, the use of co‐ and counter‐current illuminated reactors, implementing larger path lengths, without altering the reactor's geometry, is of interest. In this article, we report a simple model to determine the conversion obtained by co‐ and counter‐current illumination techniques and compare against the current state‐of‐the‐art. Via experimental validation, we report the use of co‐ and counter‐current illumination to significantly boost the PSTY, a measure for photochemical reactor productivity, by a factor of 5 to 6 for same input concentration of reagent, solemnly by illuminating the reactor via co‐ and counter‐current (axially) instead of cross‐current (radially). Furthermore, we report that simply increasing the reagent concentration, thus absorbance, has a large influence on productivity, thus PSTY, of the reactor. By assessing the reactor's performance parameters, derived by modeling, which are the initial absorbance value (A) and the quantum photon balance (ρϕ), the reactor's operating point can be determined and adapted to operate in a more productive and efficient regime.
Evaluation of Thermoelectric Properties of Ag0.366Sb0.558Te
Authors: Liu Hongxia , Li Wen , Shen Hongwei , Zhang Xinyue , Lin Siqi , Pei Yanzhong 
Published: March 2020

AbstractTernary AgSbTe2 materials are frequently reported to show a promising thermoelectric performance, due to the intrinsically low lattice thermal conductivity and complex valence band structure. However, stoichiometric AgSbTe2 is found to be thermodynamically unstable and would partially decompose into Ag2Te and Sb2Te3 during thermal cycling. Instead, Ag0.366Sb0.558Te is the composition for stabilizing the single‐phase according to the Ag2Te‐Sb2Te3 phase diagram, while the thermoelectric transport properties have rarely been reported and are the focus of this work. Sn/Sb substitution is found to effectively increase not only the carrier concentration from ≈5 × 1019 cm−3 to ≈4 × 1021 cm−3, but also the density‐of‐states effective mass, leading to an enhanced Seebeck coefficient along with a decreased carrier mobility. Single parabolic band (SPB) model with acoustic phonon scattering enables a good understanding on the charge transport. The increased carrier concentration effectively suppresses the bipolar effect at high temperatures. As a result, a peak zT of ≈1.3 and an average of ≈0.9 are achieved.
C‐H‐Bindungsaktivierung durch einen Imidocobalt(III)‐ und den resultierenden Amidocobalt(II)‐Komplex
Authors: Reckziegel Alexander , Pietzonka Clemens , Kraus Florian , Werncke C. Gunnar 
Published: March 2020

AbstractDer 3d‐Metall‐vermittelte Nitrentransfer ist Gegenstand intensiver Forschung aufgrund seines Potentials als atomökonomischer und umweltfreundlicher Ansatz zur direkten Aminierung (un)funktionalisierter C‐H‐Bindungen. Wir berichten nun über die Isolierung und Charakterisierung eines selten trigonalen Imidocobalt(III)‐Komplexes mit einer sehr langen Cobalt‐Imid‐Bindung. Er kann auf intermolekularer Weise, präzedenzlos für Imidocobaltkomplexe, starke C‐H‐Bindungen mit einer Bindungsdissoziationsenergie von bis zu 92 kcal mol−1 spalten. Dies resultiert in dem Amidocobalt(II)‐Komplex [Co(hmds)2(NHtBu)]−. Kinetische Studien diesbezüglich deuten auf einen H‐Atomtransfer‐Mechanismus. Erstaunlicherweise ist das Cobalt(II)amid in Abhängigkeit des Substrats auch in der Lage, die H‐Atomabstraktion oder einen schrittweisen Protonen‐/Elektronentransfer durchzuführen. Eine cobaltkatalysierte Substratdehydrogenierung unter Verwendung eines Organoazids wird gezeigt.
Preparation and properties of Styrene‐Butyl Acrylate resin co‐encapsulated Pigment Red 48:2 and Oxidized Polyethylene wax composite nanoparticles
Authors: Zhang Kui , Ye Mingquan , Han Aijun , Chen Xin 
Published: February 2020

AbstractIn this study, the Pigment Red 48:2 (PR48:2) and oxidized polyethylene (OPE) wax were evenly dispersed in the aqueous phase by ball‐milling method, and then the composite nanoparticles of styrene‐butyl acrylate (P(St/BA)) resin co‐encapsulated PR48:2 and OPE wax were prepared via in‐situ emulsion polymerization. The morphology, size distribution, composition, thermal properties, colorimetric performance, acid–alkaline resistance, and anti UV‐aging ability of the encapsulated nanoparticles were characterized by different analytical techniques. When the sodium dodecyl sulfate (SDS) concentration was 0.01 mol/L, the average size of encapsulated nanoparticles was about 120 nm, the particle dispersion index (PDI) was 0.132, and composite nanoparticles owned narrow size distribution and clear core–shell structure. Compared with original pigment, the encapsulated nanoparticles have better anti UV‐aging property and acid–alkaline resistance. When the PR48:2 content was 0.5 g, the color changes of the encapsulated nanoparticles after soaking in alkaline solution for 30 days and UV light exposure for 60 days were only 1.70 and 6.59, respectively, indicating that the encapsulated nanoparticles have excellent color stability.
Trends and spatial analysis of temperature and rainfall patterns on rice yields in Nigeria
Authors: Akinbile Christopher O. , Ogunmola Olabanji O. , Abolude Akintayo T. , Akande Samuel O. 
Published: March 2020

AbstractTrends and spatial analysis of temperature and rainfall on rice yield in Nigeria was carried out. Forty year of past trends (1970–2010) was conducted with climate data obtained from the International Institute of Tropical Agriculture, Ibadan, Nigeria while upland rice yield data were obtained from the Food and Agriculture Organization. Six cities, one in each of the six agro‐ecological zones which were Calabar, Enugu, Ikeja, Ilorin, Kaduna, and Maiduguri were selected. Geographic information systems mapping for spatial analysis of temperature and rainfall over Nigeria was carried out. Mann–Kendall, Sens' tests, Pettitt's, and Buishand's tests and multiple linear regressions were used as statistical tools for analysis. Increasing rainfall trends in Enugu, Calabar, and Ikeja but decreasing trends were observed in Ilorin Kaduna and Maiduguri while temperature showed increasing trends in all the cities in the last four decades. Statistically significant positive trends of rice yield, rainfall, and temperature were observed in Ikeja and Maiduguri in the last four decades. Mann–Kendall tests showed that rice yield and temperature had generally statistically significant positive trends in Calabar Ilorin Kaduna, and Enugu while rainfall and yield were significant in Calabar Enugu but not significant in Ilorin and Maiduguri adaptation strategies to genetically modify rice varieties and effective water use strategies in areas of rainfall deficit are recommended to ensure food security.
An evaluation of tropical cyclone forecast in the Southwest Indian Ocean basin with AROME‐Indian Ocean convection‐permitting numerical weather predicting system
Authors: Bousquet Olivier , Barbary David , Bielli Soline , Kebir Selim , Raynaud Laure , Malardel Sylvie , Faure Ghislain 
Published: March 2020

AbstractIn order to contribute to ongoing efforts on tropical cyclone (TC) forecasting, a new, convection‐permitting, limited‐area coupled model called AROME‐Indian Ocean (AROME‐IO) was deployed in the Southwest Indian Ocean basin (SWIO) in April 2016. The skill of this numerical weather predicting system for TC prediction is evaluated against its coupling model (European Center for Medium Range Weather Forecasting‐Integrated Forecasting System [ECMWF‐IFS]) using 120‐hr reforecasts of 11 major storms that developed in this area over TC seasons 2017–2018 and 2018–2019. Results show that AROME‐IO generally provides significantly better performance than IFS for intensity (maximum wind) and structure (wind extensions, radius of maximum wind) forecasts at all lead times, with similar performance in terms of trajectories. The performance of a prototype, 12‐member ensemble prediction system (EPS), of AROME‐IO is also evaluated on the case of TC Fakir (April 2018), a storm characterized by an extremely low predictability in global deterministic and ensemble models. AROME‐IO EPS is shown to significantly improve the predictability of the system with two scenarios being produced: a most probable one (~66%), which follows the prediction of AROME‐IO, and a second one (~33%) that closely matches reality.
Genetic counseling of high‐risk isolated populations: A worldwide challenge
Authors: Sagi‐Dain Lena , Weissman Irith , Cohen‐Kfir Nehama , Kalfon Limor , Edri Nurit , Shasha Lavski Hadas , Peleg Amir , Falik‐Zaccai Tzipora C. 
Published: March 2020

AbstractBackgroundIsolated populations with high rates of consanguinity and genetic disorders can be found in most parts of the world. The aim of our paper was to highlight the unique challenges faced in genetic counseling for such patients and to discuss the ways to facilitate the difficulties, with an emphasis on the crucial role of electronic medical records (EMR).CaseWe report a couple presenting with elevated maternal alpha‐fetoprotein in three pregnancies, in which an erroneous diagnosis of epidermolysis bullosa was established in the past and carried along through several years. The live born proband had no evidence of skin disease; however, soon after birth she was diagnosed with congenital nephrotic syndrome. Sequencing of NPHS1 gene yielded a homozygous likely pathogenic genetic variant c.2104G > A (p.Gly702Arg). Population screening performed in the village of residence revealed a carrier frequency of 1–47. This high frequency justified including testing for the founder genetic variant in the national program for population screening.ConclusionsOur report highlights the caution, suspicion and time investment which should be practiced and addressed in genetic counseling of high‐risk isolated populations. Using EMR may facilitate reaching the correct diagnosis, enable accurate genetic counseling and provide information for decision‐making to the couples, as well as “save” a large community from devastating diseases.
Determination of free clindamycin, flucloxacillin or tedizolid in plasma: Pay attention to physiological conditions when using ultrafiltration
Authors: Dorn Christoph , Schießer Selina , Wulkersdorfer Beatrix , Hitzenbichler Florian , Kees Martin G. , Zeitlinger Markus 
Published: March 2020

AbstractPharmacokinetic/pharmacodynamic indices of anti‐infective drugs should be referenced to free drug concentrations. In the present study, clindamycin, flucloxacillin and tedizolid have been determined in human plasma by HPLC–UV. The drugs were separated isocratically within 3–6 min on a C18 column using mixtures of phosphate buffer–acetonitrile of pH 7.1–7.2. Sample treatment for the determination of total drug concentrations in plasma included extraction/back‐extraction (clindamycin) or protein precipitation (flucloxacillin, tedizolid). The free drug concentrations were determined after ultrafiltration. An ultrafiltration device with a membrane consisting of regenerated cellulose proved to be suitable for all drugs. Maintaining a physiological pH was crucial for clindamycin, whereas maintaining body temperature was essential for tedizolid. The methods were applied to the analysis of total and free drug concentrations in clinical samples and were sufficiently sensitive for pharmacokinetic studies and therapeutic drug monitoring.
Comparative study on efficiency of nutmeg microencapsulation (freeze‐drying method) using native and OSA sorghum starch as wall materials in combination with gum arabic
Authors: Arshad Hira , Ali Tahira Mohsin , Hasnain Abid 
Published: March 2020

AbstractBackground and objectivesNutmeg oleoresin (Myristica fragrans Houtt.) is used widely in the culinary, medicine, and ornamental products and is known for significant antioxidant, antifungal, antimicrobial, and pharmacological properties. Quality of nutmeg oleoresin can be retained through encapsulation techniques which suppresses the degradation of flavoring ingredients. The main objective of this research was to estimate the suitability and feasibility of sorghum starch (native and octenyl succinic anhydride) as shell material in combination with gum arabic.FindingsMost of the emulsion formulations showed better stability after 24 hr. The freeze‐dried nutmeg microcapsules had excellent flow properties. The freeze‐dried powdered samples showed flake‐shaped microgranules with various sizes with no apparent cracks and holes on external surfaces. The studied wall matrices comprising 1 portion of sorghum starch with 2 portions of gum arabic resulted in high oil retention (99.4%), while GA:OSA showed the highest encapsulation efficiency (92.87%). The sample composed of 1:2 ratio of gum arabic with OSA starch resulted in the lowest peroxide value after 60 days of storage.ConclusionIn the current study, coating materials arabic gum, sorghum native starch, and modified OSA starch worked as potential source to encapsulate nutmeg oleoresin by freeze‐drying. The highest encapsulation efficiency of 92.87% with lower surface oil (0.33 g/10 g) was obtained by gum arabic and native starch in a ratio of 1:3.Novelty and significanceThe research introduces the sorghum starch (native and OSA‐modified form) as innovative wall material for microencapsulation of nutmeg oleoresin using freeze‐drying method with remarkable encapsulation efficiency.
Enhancement of the chiroptical response of α‐amino acids via N‐substitution for molecular structure determination using vibrational circular dichroism
Authors: Polavarapu Prasad L. , Santoro Ernesto , Covington Cody L. , Raghavan Vijay 
Published: March 2020

AbstractThe chiroptical response in the form of vibrational circular dichroism (VCD) in the midinfrared region is found to be enhanced when a hydrogen of amino group of l‐tryptophan is substituted with acetyl, acryloyl, or maleyl group. The order of preference for VCD enhancement is found to be acryloyl > acetyl > maleyl group. The resulting experimental VCD spectra are also found to be satisfactorily reproduced by the quantum mechanical (QM) predicted spectra. The QM predicted spectra were simulated using the conformer populations, (a) predicted by Gibbs energies and (b) optimized to maximize the similarity between experimental and predicted VCD spectra. It is found that the conformer populations predicted by Gibbs energies do not yield the maximum possible similarity between experimental and the QM predicted spectra. This work identifies the N‐substitution of α‐amino acids and determining the conformer populations that best reproduce the experimental spectra as two new approaches for molecular structure determination.
The relationship between early maladaptive schemas and interpersonal problems: A meta‐analytic review
Authors: Janovsky Thomas , Rock Adam J. , Thorsteinsson Einar B. , Clark Gavin I. , Murray Clara V. 
Published: February 2020

AbstractEarly maladaptive schemas (EMSs) have been hypothesized to be associated with interpersonal problems. Furthermore, a stronger contention is that EMSs impact negatively on, or cause, interpersonal problems. The aims of this meta‐analysis were (a) to assess the strength of the association between EMSs and interpersonal problems, (b) clarify which EMSs are most strongly associated with interpersonal problems, (c) examine any possible moderators on the relationship between EMSs and interpersonal problems, and (d) examine whether any empirical evidence exists supporting a causal relationship between EMSs and interpersonal problems. A comprehensive systematic literature search and meta‐analysis were conducted using the PRISMA guidelines for systematic reviews. A total of 49 empirical studies were reviewed investigating EMSs and interpersonal problems. EMSs were found to have a moderate positive association with interpersonal problems with different EMSs having small to moderate effect sizes. To date, there has been limited evidence supporting a causal effect of EMSs on interpersonal problems. Possible limitations and avenues for future research were discussed.