bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Synergy Between a Dynamic Educational Environment of a Pre-School Educational Institution and the Physical Activity of Children
Authors: Strazdienė Neringa , Burkė Aistė 
Published: February 2020

Movement is crucial at a pre-school age: it enables a child to gain experience, develop normally, grow up healthy, shape their own movement and health habits that in most cases continue throughout their lives. In recent years the tendencies of deterioration in health in pre-school children have been observed, and they are associated with insufficient physical activity (hereinafter PA). The synergy between an educational environment of a pre-school educational institution and PA of children sets up conditions for a co-effect of both factors on a child’s personality, maturity and health which is greater and more prominent than the effect of these factors acting separately. The aim of the research is to highlight aspects of the synergy between a dynamic educational environment of a pre-school educational institution and the PA of children and to disclose the main features of the dynamic educational environment. The article based on the analysis of scientific literature and documents defines the concept of a dynamic educational environment, which is treated as a space where synergistic interaction between architectural and educational dimensions promotes the activities of children and their PA enhancing the health of children and having a consistent effect on a personal maturity. The architectural dimension consists of the following elements: the function and the concept of an object (interior, exterior, landscape), architectural artistic–material expression, planned and spatial solutions, visual and functional relations, contextuality, construction solutions, etc. The educational dimension consists of the following elements: the objective of education, its content, educational methods, forms, means, relationship between a teacher and a learner, psychological atmosphere, etc. The educational process can be easily constructed in a dynamic educational environment to achieve the integrity of activities in different areas of educational achievements: protection and enhancement of health, social, cognitive, communication, artistic, etc.The analysis of examples of foreign architecture of pre-school institutions and scientific insights highlighted the features of a dynamic education environment: specific to a child’s age, flexible, dynamic, open, mobile and functional, sustainable and material, containing obstacles and secure, cosy and playful. The architectural concept and its elements of a dynamic educational environment should promote the natural movement of children even when no educational PA means are applied.
Fever After Influenza, Diphtheria-Tetanus-Acellular Pertussis, and Pneumococcal Vaccinations
Authors: Walter Emmanuel B. , Klein Nicola P. , Wodi A. Patricia , Rountree Wes , Todd Christopher A. , Wiesner Amy , Duffy Jonathan , Marquez Paige L. , Broder Karen R. 
Published: February 2020

BACKGROUND:
Administering inactivated influenza vaccine (IIV), 13-valent pneumococcal conjugate vaccine (PCV13), and diphtheria-tetanus-acellular pertussis (DTaP) vaccine together has been associated with increased risk for febrile seizure after vaccination. We assessed the effect of administering IIV at a separate visit from PCV13 and DTaP on postvaccination fever.

METHODS:
In 2017–2018, children aged 12 to 16 months were randomly assigned to receive study vaccines simultaneously or sequentially. They had 2 study visits 2 weeks apart; nonstudy vaccines were permitted at visit 1. The simultaneous group received PCV13, DTaP, and quadrivalent IIV (IIV4) at visit 1 and no vaccines at visit 2. The sequential group received PCV13 and DTaP at visit 1 and IIV4 at visit 2. Participants were monitored for fever (≥38°C) and antipyretic use during the 8 days after visits.

RESULTS:
There were 110 children randomly assigned to the simultaneous group and 111 children to the sequential group; 90% received ≥1 nonstudy vaccine at visit 1. Similar proportions of children experienced fever on days 1 to 2 after visits 1 and 2 combined (simultaneous [8.1%] versus sequential [9.3%]; adjusted relative risk = 0.87 [95% confidence interval 0.36–2.10]). During days 1 to 2 after visit 1, more children in the simultaneous group received antipyretics (37.4% vs 22.4%; P = .020).

CONCLUSIONS:
In our study, delaying IIV4 administration by 2 weeks in children receiving DTaP and PCV13 did not reduce fever occurrence after vaccination. Reevaluating this strategy to prevent fever using an IIV4 with a different composition in a future influenza season may be considered.
ÇİN’İN KÜRESELLEŞME İÇİNDE ROLÜ: YENİ BİR HEGEMON MU?
Authors: ŞİŞMAN Deniz 
Published: February 2020

Çin 1970’li yıllar ile başlayan dışa açılma politika uygulamaları ile giderek güçlenen bir küresel aktör rolünü üslenmektedir. Bu süreçte üretim, ticaret, inovasyon, enerji kullanımı ve ulusötesi sermaye konularında yaşadığı çarpıcı gelişmeler ve ortalama en hızlı büyüyen ülke olmanın getirdiği avantajlar neticesinde Çin’in küreselleşmede mevcut hegemonyayı ele geçirmek gibi bir niyetinin ve gücünün olup olmadığı konusu, bu makalenin ana sorusunu oluşturmaktadır. Bu nedenle makalede Çin’in işçi maliyetleri ile ortaya çıkan avantajlarının ve ülkedeki büyümenin, Lewis Dönüm Noktası (LTP) ve Orta Gelir Tuzağı kavramsal çerçevesiyle sorgulanması, özellikle küresel kriz sonrası oluşan koşullar gözönünde bulundurularak yapılmaktadır. Çalışmada, Çin’de Orta Gelir Tuzağının aşılması yolunda toplam faktör verimliliğinin arttırılması ve diğer önlemlerin yanısıra küresel kriz ve ABD-Çin Ticaret Savaşlarının Çin ekonomisine etkileri sorgulanmıştır.
Jel Kodları: B27, F23, F43, F63, G38, J61, N35
Dose Intensity of Chemotherapy for Childhood Cancers
Authors: Smith Malcolm , Abrams Jeffrey , Trimble Edward L. , Ungerleider Richard S. 
Published: February 2020

Abstract
Since the formulation of the “dose-intensity” concept of anticancer therapy in the mid-1980s, the concept that “more is better” has gained general acceptance among pediatric oncologists. However, recently published clinical trials results for adults with breast cancer, germ-cell tumors, and ovarian cancer raise questions about the value of dose intensification in improving outcome. Given the differences in sensitivity between pediatric and adult tumors to cytotoxic agents, the results from these adult trials suggest a need for caution but do not suggest that evaluations of dose intensity for pediatric tumors are unwarranted (especially for a tumor such as Ewing's sarcoma, which is especially sensitive to alkylating agents).
Since dose-intensive therapies have significant short- and long-term costs for the patient, it is important to obtain reliable data concerning possible benefits of this strategy. Toward this end, NCI-sponsored randomized clinical trials evaluating the role of dose intensification have been initiated for several tumors of children (including neuroblastoma, germ-cell tumors, Ewing's sarcoma, and brain tumors in infants). These trials should be completed and reported in the next two to three years, and they may make unique contributions in defining the benefits and limitations of dose intensity as a cancer treatment strategy.
In the long term, however, the utility of dose intensification is limited for children with cancer because of the inherent toxicities associated with its application. Identification of agents that more specifically target tumor cells is essential. Fortunately, pediatric tumor cells do have unique biological characteristics that may be susceptible to targeting for therapeutic benefit.
Lung Cancer Highlights
Authors: Lynch Thomas J. 
Published: February 2020

Abstract
Have we made any progress in the treatment of advanced non-small cell lung cancer (NSCLC) over the past 15 years? After hearing the Eastern Cooperative Oncology Group (ECOG) 1594 presented by Dr. Joan Schiller at the plenary session of the 36th Annual Meeting of ASCO, it is hard to be certain. Schiller reported the results of one of the world's largest randomized trials in metastatic lung cancer comparing four platinum-based doublets. There were no differences in survival (primary endpoint) or response between these four regimens, although the cisplatin/gemcitabine arm had a superior time to progression. In her commentary on this study, Dr. Francis Shepherd concluded that progress in the treatment of metastatic lung cancer has occurred at “a snail's pace.”
Despite the disappointing results of ECOG 1594, there were notable trials describing new agents with novel mechanisms of action reported at this year's ASCO meeting. In small-cell lung cancer, the combination of cisplatin/ irinotecan was found to be superior to cisplatin/etoposide. For NSCLC, novel agents Iressa anti-epidermal growth factor receptor tyrosine kinase and anti-vascular endothelial growth factor monoclonal antibody appear promising.
Combination Versus Sequential Single-Agent Therapy in Metastatic Breast Cancer
Authors: Miles David , Minckwitz Gunter , Seidman Andrew D. 
Published: February 2020

Abstract

Learning Objectives
After completing this course, the reader will be able to:
Describe the current and evolving role of combination therapy in the management of the breast cancer patient with advanced (metastatic) disease. Appreciate the principles of combination treatment design for breast cancer management. Describe those combination treatment regimens, which are designed rationally. Explain the current status of combination or sequential treatment in the management of advanced breast cancer and how clinicians might select options based on patient characteristics.
Access and take the CME test online and receive one hour of AMA PRA category 1 credit at CME.TheOncologist.com
The optimal treatment approach in metastatic breast cancer is controversial. Until recently, the arguments for administering antitumor agents sequentially in the metastatic setting have traditionally outweighed those for administering agents in combination. Older, often empirically designed drug combinations were no more effective and often more toxic than monotherapy, compromising quality of life for little or no clinical benefit. However, more recent studies show that combination and sequential therapy both have their place in the treatment of metastatic breast cancer, with the heterogeneity of breast cancer demanding flexibility in approach. Newer drug combinations, such as paclitaxel/trastuzumab or capecitabine/docetaxel, show survival advantages over single-agent therapy and have manageable safety profiles. Such combination treatments may be preferable to sequential therapy for patients requiring urgent reduction in their tumor burden. Sequential therapy allows the optimal delivery of single-drug therapy and potentially reduces the risk of toxicity, which may improve quality of life. Sequential therapy may be especially appropriate in frail or elderly patients, who may be unable to tolerate the toxicity of combination therapy, or in patients with slowly growing tumors. This article expands on these issues by reviewing trials comparing combination regimens with sequential approaches.
RELIABILITY ANALYSIS FOR CRITICAL COMPONENTS ON THE RSG-GAS PRIMARY COOLING SYSTEM
Authors: Hartini Entin , Susmikanti Mike 
Published: February 2020

ABSTRACTRELIABILITY ANALYSIS FOR CRITICAL COMPONENTS IN PRIMARY RSG-GAS COOLING SYSTEM. Reliability is the probability that a system will function normally when it is used for the desired time period under specific operating conditions. This study aims to analyze the reliability, distribution function of damage and rate of damage by using the frequency data of damage, downtime and time data between the damage of each component on the primary cooling system RSG- GAS. The methodology used is the Test of damage distribution estimated as an exponential distribution. Test the exponential distribution using the Bartlett test. Further estimation of data distribution parameters. Based on the parameters of the data distribution, the reliability and rate of damage can be calculated for the critical component of the primary cooling system. Damage data is obtained from maintenance data for core 70 until 88 (2010-2015). The results showed that in the primary cooling system the highest failure occurred for component JE-01 (AP01-02) with downtime = 112 (day) and failure frequency presentation = 75%. The failure rate (λ) of 0.000215438 with the reliability value for the last year amounted to 99.83%. Keywords: Downtime, Damage frequency, Reliability, maintenance, RSG-GAS
Pelatihan Pemanfaatan dan Pengembangan Bahan Ajar Digital Berbasis Multimedia Interaktif untuk Menghadapi Era Revolusi Industri 4.0
Authors: Smaragdina Azhar Ahmad , Nidhom Ahmad Mursyidun , Soraya Dila Umnia , Fauzi Rochmad 
Published: February 2020

Kegiatan diperuntukkan guru-guru SMP di desa Turirejo Kec Lawang, dengan tujuan utama desa ini dapat menjadi pilot project dimana nantinya program pengabdian ini dapat berlanjut di beberapa desa di kecamatan yang lain. Era revolusi industri 4.0 telah membawa banyak perubahan pada berbagai aspek kehidupan dimana teknologi memiliki peranan yang sangat besar dan menjadi motor utama perubahan di setiap aspek. Guru idealnya memiliki kemampuan untuk mengembangkan bahan ajar dan media pembelajaran yang dapat diakses melalui perangkat digital, serta mampu memanfaatkan sumber-sumber belajar lain yang sesuai dengan karakteristik digital native. Hasil kegiatan telah dapat meningkatkan kapabilitas para guru dalam memanfaatkan dan mengembangkan bahan ajar digital berbasis multimedia interaktif, hal ini berdampak pada proses pembelajaran yang menjadi semakin variatif. Kata kunci— bahan ajar digital, literasi digital, multimedia interaktif, pelatihan, revolusi industry 4.0. Abstract The activity is aimed at junior high school teachers in Turirejo village, Lawang district, with the main objective of this village being a pilot project where this community service program is needed to be continued in several villages in other sub-districts. The era of the industrial revolution 4.0 has brought many changes to various aspects of life while technology has a very big role and is the main motor of change in every aspect. The teacher ideally has the ability to develop teaching materials and learning media that can be accessed through digital devices, and be able to use other learning resources that are compatible with the original digital characteristics. The results of the activities have improved the ability of teachers to develop and develop interactive multimedia-based digital teaching materials, this has improved the learning process which has become increasingly varied. Keywords— digital teaching materials, digital literacy, interactive multimedia, training, industrial revolution 4.0
INFLUENCE OF ACHIEVEMENT MOTIVATION AND PSYCHOLOGICAL ADJUSTMENT ON ACADEMIC ACHIEVEMENT: A CROSS-SECTIONAL STUDY OF SCHOOL STUDENTS
Authors: Vineeth Kumar V , Tankha Geetika 
Published: February 2020

Purpose: The aim of the current research was to understand the role of achievement motivation and psychological adjustment on the academic performance of the school students.
Methodology: A cross-sectional research design was employed for the study. A sample of 283 urban adolescent school students participated in the study. The students were administered measures of achievement motivation and psychological adjustment. The total percentage of marks secured in the tenth standard was used as the measure of academic performance. Pearson’s correlation coefficient and multiple hierarchical regression analysis were performed to analyze the obtained data. SPSS version 21 was used for data analysis.
Main Findings: The results revealed a significant association of achievement motivation and educational adjustment with the academic performance of the students. However, there was no significant association between emotional and social adjustment with academic performance.
Applications: The observations shed light on how cultivating enhanced student engagement and nurturing aspirations both within and outside classrooms may enhance the academic achievement of school students. Thus, the findings can provide greater insight to teachers, psychologists, and educational institutions to better plan the academic environment around the students.
Novelty/Originality: The study gives a contemporary model to enhance the academic performance of students. Contrary to the popular perception, the results of the current study indicate no significant association of emotional and social adjustment with academic performance. However, educational adjustment and achievement motivation are associated with academic performance.
Prediction of Banks Distress – Regional Differences and Macroeconomic Conditions
Authors: Iwanicz-Drozdowska Małgorzata , Ptak-Chmielewska Aneta 
Published: February 2020

In this study we focus on distress events of European banks over the period of 1990–2015, using unbalanced panel of 3,691 banks. We identify 132 distress events, which include actual bankruptcies as well as bailout cases. We apply CAMEL‑like bank‑level variables and control macroeconomic variables (GDP, inflation, unemployment rate). The analysis is based on traditional logistic regression and k‑means clustering. We find, that the probability of distress is connected with macroeconomic conditions via regional grouping (clustering). Bank‑level variables that were stable predictors of distress from 1 to 4 years prior to event are equity to total assets ratio (leverage) and loans to funding (liquidity).
From macroeconomic factors, the GDP growth is a reasonable variable, however with differentiated impact: for 1 year distance high distress probability is connected with low GDP growth, but for 2, 3 and 4 year distance: high distress probability is conversely connected with high GDP growth.
This shows the changing role of macroeconomic environment and indicates the potential impact of favorable macroeconomic conditions on building‑up systemic problems in the banking sector.
Analysis Methods Verification of Boron in River Water Using the Uv-Vis Spectrophotometer with Curcumin Complex as Alternative Practical Educations
Authors: Setyawati Amri 
Published: February 2020

Boron is one of the industrial wastes included in the hazardous and toxic materials category. The purpose of this study was to determine river water sample levels and determine the value of linearity, RSD, and% recovery. The method used is under APHA - AWWA 4500 B. Some boron complexing compounds include curcumin in acetic acid, carminic acid, and quinalizarin, but in this study, curcumin complex are used because their sources in Indonesia are abundant. Curcumin gives a red complex color as an indication of the presence of boron in the sample. This phenomenon makes the learning process through practicum very interesting. Students can see the color change directly from orange to red. Students taught to produce reliable data and understand the importance of the chemist and analyst profession for the community through the practice of verification and validation methods, and the determination of the value of boron. Based on this study, it concluded that the Boron content in river water samples is 0.4766 mg / L. These results obtained from the straight-line equation that is y = 0.3446x - 0.0119 with R2 of 0.9976. The results of the RSD analysis are 0.028%, which states that the value is in the Horwitz TABLE range. Therefore, it can be accepted. Besides, the% Recovery is 86%; this value meets the analysis standard and is acceptable because it is in the range of 85% -115%. Finally, the measured boron levels in river water samples are still below the quality standard limits of the Republic of Indonesia Government Regulation Number 82 of 2001 concerning water quality treatment and water pollution control with a value of boron levels less than 1 mg / L. The boron content in a sample of river water in the Semarang area is still safe. Keywords: Boron, Practical Educations, Analytical Chemistry, Linearity, RSD, % Recovery.
Akses Pendidikan bagi Pribumi pada Periode Etis (1901-1930)
Authors: Muhammad Fakhriansyah  , Intan Ranti Permatasari Patoni  
Published: February 2020

This article examines the dynamics of the indigenous people of the Dutch East Indies' access to education during the Dutch Etichal Policy period. Considering that, the Netherlands was the longest-running country exploiting the Indies, the country was obliged to bear the burden of reciprocation on their colony. The burden of reciprocity was realised through an Ethical Policy that has three programs. They are irrigation, transmigration, and education. Of the three, Education was the program that had major impacts on the Indonesian national movement. This research used historical method. The result of this research showed us that although education had succeeded in undermining the Dutch colonial domination, the education during the Dutch Etichal Policy period was not fully given as a whole by the colonial government. Instead, it was very limited. The Dutch colonial policies, especially the one concerning education were driven by their interest of economic benefits for themselves over the improvement of the indigenous people of the Dutch East Indies' welfare.

Artikel ini membahas mengenai dinamika akses pendidikan bagi pribumi saat berlangsungya Politik Etis. Seperti yang diketahui, Belanda sebagai negara yang terlama mengeksploitasi Hindia Belanda membuat negara tersebut menanggung beban balas budi terhadap koloninya. Beban balas budi tersebut terwujud melalui program Politik Etis yang memiliki tiga program, yakni irigasi, transmigrasi, dan edukasi. Dari ketiga itu, pendidikan merupakan salah satu program Politik Etis dan salah satu program yang memiliki dampak besar bagi pergerakan nasional. Penelitian ini menggunakan metode historis dengan analisis studi kepustakaan. Hasil penelitian menunjukan meskipun pendidikan berhasil meruntuhkan dominasi kolonial, pendidikan saat periode Etis pun tidak serta merta langsung diberikan begitu saja oleh pemerintah kolonial meskipun tujuan Politik Etis adalah balas budi, pemberian pendidikan diberikan secara serba terbatas. Kebijakan-kebijakan pemerintah kolonial, khususnya di bidang pendidikan didorong oleh kepentingan keuntungan ekonomi bagi mereka sendiri alih-alih oleh motif untuk meningkatkan kesejahteraan rakyat setempat.