bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigation of the behavior of concrete‐filled high‐strength glass fiber‐reinforced polymer tubes under static and cyclic axial compression
Authors: Aslani Farhad , Deghani Ayoub , Gunawardena Yasoja 
Published: February 2020

AbstractThis experimental study investigated the load–displacement behavior, ultimate strength, and failure modes of hollow and concrete‐filled high‐strength glass fiber‐reinforced polymer (GFRP) tubes under static and cyclic axial compression. For this purpose, pultruded GFRP tubes were used which contained fibers oriented at 0°, +45°, and −45° to the longitudinal axes of the tubes. Self‐compacting concrete (SCC) was used for in‐filling the hollow GFRP tubes. The main parameters considered in the test program were the tube cross‐section, column length, and cyclic loading range. A total of 28 specimens of lengths equal to either 0.5 or 1.5 m were tested under static and cyclic axial compressive loading. The experimentally obtained load–displacement and load‐axial/hoop strain behaviors are discussed in this paper. It was verified that in‐filling the GFRP tubes with concrete can enhance their axial strength and stiffness, though it is not able to prevent the brittle nature of the failure. Hollow GFRP tubes displayed linear‐elastic behavior with a constant axial stiffness up to failure under both static and cyclic loading, while the concrete‐filled specimens exhibited a bilinear load–displacement behavior with the change in stiffness occurring at the point at which the GFRP tube starts to act as a confining jacket. Under cyclic loading, the concrete‐filled specimens suffered degradation in axial stiffness with the rate of deterioration decreasing with increasing number of cycles. However, a consistent relationship between the cyclic load range magnitude and number of cycles to failure could not be found using the experimentally obtained data.
Next-to-leading-order QCD and electroweak corrections to triple-W production with leptonic decays at the LHC
Authors: Dittmaier Stefan , Knippen Gernot , Schwan Christopher 
Published: February 2020

Abstract
We present a calculation of the next-to-leading-order QCD and electroweak corrections to WWW production with leptonically decaying W bosons at the LHC, fully taking into account off-shell contributions, intermediary resonances, and spin correlations. The contributions of the quark-antiquark-induced electroweak correction to typical fiducial cross sections at the LHC are of the order of 5–8 % and grow to tens of percent in the high-energy tails of distributions. We observe strong cancellations among the positive quark-photon and negative quark-antiquark-induced electroweak corrections. In addition to results based on full 2 → 6/7-particle next-to-leading-order matrix elements, we present a calculation based on the triple-pole approximation, which expands the matrix elements around the poles of three simultaneously resonant W bosons. The triple-pole approximation performs particularly well for integrated cross sections and for differential cross sections that are insensitive to off-shell effects, such as angular and rapidity distributions.
Improved global fit to Non-Standard neutrino Interactions using COHERENT energy and timing data
Authors: Coloma Pilar , Esteban Ivan , Gonzalez-Garcia M.C. , Maltoni Michele 
Published: February 2020

Abstract
We perform a global fit to neutrino oscillation and coherent neutrino-nucleus scattering data, using both timing and energy information from the COHERENT experiment. The results are used to set model-independent bounds on four-fermion effective operators inducing non-standard neutral-current neutrino interactions. We quantify the allowed ranges for their Wilson coefficients, as well as the status of the LMA-D solution, for a wide class of new physics models with arbitrary ratios between the strength of the operators involving up and down quarks. Our results are presented for the COHERENT experiment alone, as well as in combination with the global data from oscillation experiments. We also quantify the dependence of our results for COHERENT with respect to the choice of quenching factor, nuclear form factor, and the treatment of the backgrounds.
Polyneuropathie im Alter
Authors: Löscher W. N. , Iglseder B. 
Published: February 2020

ZusammenfassungDas periphere Nervensystem ist im Laufe des Alternsprozesses Veränderungen unterworfen. So kommt es unter anderem zu einer Abschwächung von Muskeleigenreflexen und Propriozeption. Davon abzugrenzen sind Polyneuropathien als krankhafte Veränderungen des peripheren Nervensystems. Die jährliche Inzidenz von Polyneuropathien wird auf 118/100.000 geschätzt, die Prävalenz liegt bei etwa 1 %, für ältere Populationen werden 7 % angegeben. Die Ursachen sind vielfältig und ähnlich den Ursachen von Neuropathien des jüngeren Alters: Neben metabolischen, immunvermittelten, hereditären, toxischen und infektiösen Ätiologien können Polyneuropathien Ausdruck von Systemerkrankungen sein. Entsprechend der Altersverteilung der verschiedenen Ursachen sind Neuropathien im Zusammenhang mit Diabetes, monoklonalen Gammopathien und Malignomen im Alter häufiger. Allerdings nimmt der Anteil der kryptogenen Neuropathien, also ohne eindeutige Ursache, mit dem Alter zu. Bei alten Menschen führen Polyneuropathien zu einer zusätzlichen Beeinträchtigung der Mobilität und einem erhöhten Sturzrisiko, was auch die Abklärung funktioneller Fähigkeiten erforderlich macht.
Infektionen mit dem humanen Immundefizienzvirus bei Kindern in Deutschland, 1999–2016
Authors: Marcus U. , Beck N. 
Published: February 2020

Zusammenfassung
Hintergrund
Mutter-Kind-Übertragungen von humanem Immundefizienz Virus (HIV) sind durch antiretrovirale Therapie der Schwangeren und weitere medizinische Maßnahmen (Sectio-Entbindung, Postexpositionsprophylaxe beim Neugeborenen, Stillverzicht) verhinderbar. Weiterhin erfolgende Übertragungen sind überwiegend Folge mangelhafter Umsetzung der bekannten wirksamen Maßnahmen. Stand und Probleme bei der Erreichung einer Eliminierung von Mutter-Kind-Übertragungen von HIV in Deutschland werden beschrieben.

Methoden
Hauptquelle der Daten sind pseudonymisierte Meldedaten des HIV-Melderegisters am Robert Koch-Institut (RKI). Mittels einer intensivierten Surveillance für HIV-Meldungen zu Kindern werden Angaben zum Geburtsland, zum mütterlichen Herkunftsland und zur Kenntnis und zum Management der mütterlichen HIV-Infektion in der Schwangerschaft bei seit 1999 geborenen, mit HIV infizierten Kindern erhoben.

Ergebnisse
Bis Ende 2018 wurden bei zwischen dem 01.01.1999 und dem 31.12.2016 geborenen Kindern im Alter unter 15 Jahren in Deutschland 331 HIV-Diagnosen gemeldet. Bei 313 war eine Mutter-Kind-Übertragung der wahrscheinlichste Übertragungsweg. Von diesen 313 Kindern wurden 162 (52 %) in Deutschland geboren, aber nur 26 % der Mütter waren deutscher Herkunft. Die HIV-Übertragungshäufigkeit bei in Deutschland geborenen Kindern sank von 1,8/100.000 Lebendgeburten im Zeitraum 1999–2007 auf 0,8/100.000 im Zeitraum 2008–2016. Bei 59 % der in Deutschland geborenen Kinder war der HIV-Status der Mutter den betreuenden Ärzt*innen zum Zeitpunkt der Geburt nicht bekannt.

Schlussfolgerung
Ein fehlendes HIV-Testangebot für die Schwangere war Hauptursache für Übertragungen bei bis 2007 geborenen Kindern; bei später geborenen Kindern waren die Gründe vielfältiger und hingen oft mit mütterlicher Migration und Zugangsbarrieren in das Versorgungssystem zusammen.
Maximum product of spacings prediction of future record values
Authors: Volovskiy Grigoriy , Kamps Udo 
Published: February 2020

AbstractA spacings-based prediction method for future upper record values is proposed as an alternative to maximum likelihood prediction. For an underlying family of distributions with continuous cumulative distribution functions, the general form of the predictor as a function of the estimator of the distributional parameters is established. A connection between this method and the maximum observed likelihood prediction procedure is shown. The maximum product of spacings predictor turns out to be useful to predict the next record value in contrast to likelihood-based procedures, which provide trivial predictors in this particular case. Moreover, examples are given for the exponential and the Pareto distributions, and a real data set is analyzed.
On the finiteness of the derived equivalence classes of some stable endomorphism rings
Authors: August Jenny 
Published: February 2020

AbstractWe prove that the stable endomorphism rings of rigid objects in a suitable Frobenius category have only finitely many basic algebras in their derived equivalence class and that these are precisely the stable endomorphism rings of objects obtained by iterated mutation. The main application is to the Homological Minimal Model Programme. For a 3-fold flopping contraction $$f :X \rightarrow {\mathrm{Spec}\;}\,R$$

f
:
X
→

Spec

R

, where X has only Gorenstein terminal singularities, there is an associated finite dimensional algebra $$A_{{\text {con}}}$$

A
con

known as the contraction algebra. As a corollary of our main result, there are only finitely many basic algebras in the derived equivalence class of $$A_{\text {con}}$$

A
con

and these are precisely the contraction algebras of maps obtained by a sequence of iterated flops from f. This provides evidence towards a key conjecture in the area.
Modulation of value-based decision making behavior by subregions of the rat prefrontal cortex
Authors: Verharen Jeroen P. H. , den Ouden Hanneke E. M. , Adan Roger A. H. , Vanderschuren Louk J. M. J. 
Published: February 2020

Abstract
Rationale
During value-based decision-making, organisms make choices on the basis of reward expectations, which have been formed during prior action-outcome learning. Although it is known that neuronal manipulations of different subregions of the rat prefrontal cortex (PFC) have qualitatively different effects on behavioral tasks involving value-based decision-making, it is unclear how these regions contribute to the underlying component processes.

Objectives
Assessing how different regions of the rodent PFC contribute to component processes of value-based decision-making behavior, including reward (or positive feedback) learning, punishment (or negative feedback) learning, response persistence, and exploration versus exploitation.

Methods
We performed behavioral modeling of data of rats in a probabilistic reversal learning task after pharmacological inactivation of five PFC subregions, to assess how inactivation of these different regions affected the structure of responding of animals in the task.

Results
Our results show reductions in reward and punishment learning after PFC subregion inactivation. The prelimbic, infralimbic, lateral orbital, and medial orbital PFC particularly contributed to punishment learning, and the prelimbic and lateral orbital PFC to reward learning. In addition, response persistence depended on the infralimbic and medial orbital PFC. As a result, pharmacological inactivation of the infralimbic and lateral orbitofrontal cortex reduced the number of reversals achieved, whereas inactivation of the prelimbic and medial orbitofrontal cortex decreased the number of rewards obtained. Finally, using simulated data, we explain discrepancies with a previous study and demonstrate complex, interacting relationships between conventional measures of probabilistic reversal learning performance, such as win-stay/lose-switch behavior, and component processes of value-based decision-making.

Conclusions
Together, our data suggest that distinct components of value-based learning and decision-making are generated in medial and orbital PFC regions, displaying functional specialization and overlap, with a prominent role of large parts of the PFC in negative feedback processing.
Evaluation of the CT Scan as the First Examination for the Diagnosis and Therapeutic Strategy for Acute Cholecystitis
Authors: Martellotto S. , Dohan A. , Pocard M. 
Published: February 2020

AbstractBackgroundThe CT scan has supplanted the abdominal ultrasound for emergency examinations. A comparison of CT scan and ultrasound performance for the diagnosis and management of acute cholecystitis in acute care was proposed. The hypothesis is that the CT scan may be sufficient for the diagnosis of acute cholecystitis, which would allow faster progress to surgery.MethodsThe retrospective study of consecutive patients operated for acute cholecystitis or gallbladder distension with pre‐operative imaging within 48 h in one centre.ResultsBetween 2015 and 2017, a total of 341 cholecystectomies were performed in our centre. The analysis involved 120 patients. Ultrasound had better sensitivity than the CT scan, respectively, 79.4% [70.5–86.6] and 52.3% [42.5–62.1], but less specificity, with 61.5% [31.6–86.1] and 92.3% [64.0–99.8], respectively. However, there was a significant difference in favour of the CT scan for the diagnosis of complicated cholecystitis (p 0.004). The positive likelihood ratio of complicated cholecystitis is better at CT scan (7.8) [2.7–23.1] than in ultrasound (1.0) [0.1–9.7]. CT scan and ultrasound are equivalent for the diagnosis of acute cholecystitis, but CT scan is more efficient for the diagnosis of complicated cases (Youden index J 0.3 vs 0.001).ConclusionIt is possible to place the surgical indication of cholecystectomy on the only data of the CT scan. We propose a decision‐making algorithm that uses the CT scan to make the diagnosis and decide on emergency treatment for complicated cases or that allows us to propose a delayed surgery for simple cholecystitis.
Iterative particle matching for three-dimensional particle-tracking velocimetry
Authors: Rubbert A. , Schröder W. 
Published: February 2020

Abstract
A new evaluation scheme for double exposure three-dimensional particle-tracking velocimetry is proposed. Its main feature, a robust multi-pass matching algorithm, is presented and validated by investigating its performance when applied to a synthetic data set. To evaluate real measurement data, the approach is supplemented by an iterative triangulation scheme, in which the resulting particle positions are validated through the matching algorithm. The comparison with tomographic particle-image velocimetry data shows good agreement. The proposed algorithm allows this approach to be applied to volumetric measurements with seeding densities exceeding standard particle-tracking applications. Therefore, it can serve as a drop-in replacement for tomographic particle-image velocimetry at significantly reduced computational cost.

Graphic abstract
Validation of a fast prognostic score for risk stratification of normotensive patients with acute pulmonary embolism
Authors: Hobohm Lukas , Becattini Cecilia , Konstantinides Stavros V. , Casazza Franco , Lankeit Mareike 
Published: February 2020

Abstract
Background
Recent studies demonstrate an improved prognostic performance of the 2014 European Society of Cardiology (ESC) algorithm for risk stratification of patients with pulmonary embolism (PE) compared to the 2008 ESC algorithm. The modified FAST and Bova scores appear especially helpful to identify PE patients at intermediate-high risk.

Methods
We validated the prognostic performance of the modified FAST score compared to other scores for risk stratification in a post-hoc analysis of 868 normotensive PE patients included in the prospective Italian Pulmonary Embolism Registry. In-hospital adverse outcome was defined as PE-related death, mechanical ventilation, cardiopulmonary resuscitation or administration of catecholamines.

Results
Overall, 27 patients (3.1%) had an adverse outcome and 32 patients (3.7%) died. The rate of an adverse outcome was highest in the intermediate-high risk classes of the 2019 ESC algorithm (7.5%) and the modified FAST score (5.3%) while the Bova score failed to discriminate between intermediate-low and intermediate-high-risk patients. Patients classified as intermediate-high risk by the 2019 ESC algorithm (Odds Ratio [OR], 4.2 [95% CI, 1.9–9.0]) and modified FAST score (OR, 2.8 [1.3–6.2]) had a higher risk of an adverse outcome compared to patients classified by the Bova score (OR, 1.6 [0.7–3.7]). The c-index was higher for the 2019 ESC algorithm and the modified FAST score (AUC, 0.69 [0.58–0.79] and 0.67 [0.59–0.76]) compared to the Bova score (AUC, 0.64 [0.55–0.73]).

Conclusions
The 2019 ESC algorithm provided the best prognostic performance, but also the modified FAST score accurately stratified normotensive PE patients in different risk classes while the Bova score failed to identify patients at highest risk.

Graphic abstract
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system
Authors: Rawji Khalil S. , Young Adam M.H. , Ghosh Tanay , Michaels Nathan J. , Mirzaei Reza , Kappen Janson , Kolehmainen Kathleen L. , Alaeiilkhchi Nima , Lozinski Brian , Mishra Manoj K. , Pu Annie , Tang Weiwen , Zein Salma , Kaushik Deepak K. , Keough Michael B. , Plemel Jason R. , Calvert Fiona , Knights Andrew J. , Gaffney Daniel J. , Tetzlaff Wolfram , Franklin Robin J. M. , Yong V. Wee 
Published: February 2020

AbstractRemyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell population and extrinsic factors in the lesion microenvironment of older subjects contribute to this decline. Microglia and monocyte-derived macrophages are critical for successful remyelination, releasing growth factors and clearing inhibitory myelin debris. Several studies have implicated delayed recruitment of macrophages/microglia into lesions as a key contributor to the decline in remyelination observed in older subjects. Here we show that the decreased expression of the scavenger receptor CD36 of aging mouse microglia and human microglia in culture underlies their reduced phagocytic activity. Overexpression of CD36 in cultured microglia rescues the deficit in phagocytosis of myelin debris. By screening for clinically approved agents that stimulate macrophages/microglia, we have found that niacin (vitamin B3) upregulates CD36 expression and enhances myelin phagocytosis by microglia in culture. This increase in myelin phagocytosis is mediated through the niacin receptor (hydroxycarboxylic acid receptor 2). Genetic fate mapping and multiphoton live imaging show that systemic treatment of 9–12-month-old demyelinated mice with therapeutically relevant doses of niacin promotes myelin debris clearance in lesions by both peripherally derived macrophages and microglia. This is accompanied by enhancement of oligodendrocyte progenitor cell numbers and by improved remyelination in the treated mice. Niacin represents a safe and translationally amenable regenerative therapy for chronic demyelinating diseases such as multiple sclerosis.
Decoding identity from motion: how motor similarities colour our perception of self and others
Authors: Coste Alexandre , Bardy Benoît G. , Janaqi Stefan , Słowiński Piotr , Tsaneva-Atanasova Krasimira , Goupil Juliette Lozano , Marin Ludovic 
Published: February 2020

AbstractFor more than 4 decades, it has been shown that humans are particularly sensitive to biological motion and extract socially relevant information from it such as gender, intentions, emotions or a person’s identity. A growing number of findings, however, indicate that identity perception is not always highly accurate, especially due to large inter-individual differences and a fuzzy self-recognition advantage compared to the recognition of others. Here, we investigated the self-other identification performance and sought to relate this performance to the metric properties of perceptual/physical representations of individual motor signatures. We show that identity perception ability varies substantially across individuals and is associated to the perceptual/physical motor similarities between self and other stimuli. Specifically, we found that the perceptual representations of postural signatures are veridical in the sense that closely reflects the physical postural trajectories and those similarities between people’ actions elicit numerous misattributions. While, on average, people can well recognize their self-generated actions, they more frequently attribute to themselves the actions of those acting in a similar way. These findings are consistent with the common coding theory and support that perception and action are tightly linked and may modulate each other by virtue of similarity.
miRNA repertoire and host immune factor regulation upon avian coronavirus infection in eggs
Authors: Kemp Vera , Laconi Andrea , Cocciolo Giulio , Berends Alinda J. , Breit Timo M. , Verheije M. Hélène 
Published: February 2020

AbstractAvian infectious bronchitis virus (IBV) is a coronavirus with great economic impact on the poultry industry, causing an acute and highly contagious disease in chickens that primarily affects the respiratory and reproductive systems. The cellular regulation of IBV pathogenesis and the host immune responses involved remain to be fully elucidated. MicroRNAs (miRNAs) have emerged as a class of crucial regulators of numerous cellular processes, including responses to viral infections. Here, we employed a high-throughput sequencing approach to analyze the miRNA composition of the spleen and the lungs of chicken embryos upon IBV infection. Compared to healthy chicken embryos, 13 and six miRNAs were upregulated in the spleen and the lungs, respectively, all predicted to influence viral transcription, cytokine production, and lymphocyte functioning. Subsequent downregulation of NFATC3, NFAT5, SPPL3, and TGFB2 genes in particular was observed only in the spleen, demonstrating the biological functionality of the miRNAs in this lymphoid organ. This is the first study that describes the modulation of miRNAs and the related host immune factors by IBV in chicken embryos. Our data provide novel insight into complex virus-host interactions and specifically highlight components that could affect the host’s immune response to IBV infection.
Antagonistic interactions between predator and prey: mobbing of jaguars (Panthera onca) by white-lipped peccaries (Tayassu pecari)
Authors: Rampim Lilian E. , Sartorello Leonardo R. , Fragoso Carlos E. , Haberfeld Mario , Devlin Allison L. 
Published: February 2020

AbstractAmbush predators rely on stealth to successfully secure prey. Mobbing is a rarely observed anti-predation strategy used by group-living prey species whereby several individuals distract or harass a predator until it either ends the pursuit or leaves the area. Herein, we present three unique cases of white-lipped peccaries (Tayassu pecari) mobbing jaguars (Panthera onca) in the wild. White-lipped peccaries and jaguars co-occur within the study area, a large-scale ecotourism and working cattle ranch in the Brazilian Pantanal. Two cases of mobbing were recorded by video camera trap during routine surveys, and a third case was directly observed by one of the authors during telemetry triangulation of a GPS-collared individual jaguar. Our observations provide direct empirical evidence of antagonistic behavioral interactions between jaguars and white-lipped peccaries that have previously been limited to anecdotes within academic literature. We discuss the implications of this behavioral interaction for the proximate and ultimate fitness of both predator and prey.