bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroconvulsive Therapy Versus Fluoxetine in Suicidal Resolution for Patients With Major Depressive Disorder
Authors: Lin Ching-Hua , Chen Cheng-Chung , Huang Chun-Jen 
Published: March 2020

Objective
Resolution of suicidal ideation for patients with major depressive disorder is an important public health challenge. We aimed to determine whether electroconvulsive therapy (ECT) or fluoxetine was more efficacious in resolving suicidal ideation and achieving long-term protective effect against suicidality.

Methods
The data used in this study were drawn from 2 open-label trials for major depressive disorder patients receiving ECT or fluoxetine for acute treatment, together with continuation medication in the 12-week follow-up. We compared the effects of ECT and fluoxetine on suicidal ideation as scored by the suicide item on the 17-item Hamilton Rating Scale for Depression.

Results
The differences between these 2 groups in time to resolution of suicidal ideation (suicide item = 0) in the acute treatment period, and time to relapse of suicidal ideation (suicide item score ≥1 or rehospitalization for suicidality) in the follow-up period were analyzed. Electroconvulsive therapy–treated patients (n = 111) had significantly shorter time to resolution of suicidal ideation than fluoxetine-treated patients (n = 114) during acute treatment. However, there was no statistically significant difference in time to relapse of suicidal ideation between 2 groups in the 12-week follow-up period.

Conclusions
Electroconvulsive therapy was superior to fluoxetine in resolving suicidal ideation during acute treatment. Therefore, ECT should be an early consideration for suicidal patients. Electroconvulsive therapy and fluoxetine were equally effective in preventing recurrence of suicidal ideation in the 12-week follow-up period. Routine suicide risk assessments from hospital care to outpatient care are required to identify any signs of suicidal relapse.
Potentiating the anti-tumor response of tumor infiltrated T cells by NAD+supplementation
Authors: Wang Yuetong , Wang Fei , Wang Lihua , Qiu Shizhen , Yao Yufeng , Xiong Xuexue , Chen Xuyong , Ji Quanquan , Cao Jian , Li Dake , Zhang Liye , Wang Ruoning , Wang Haopeng , Fan Gaofeng 
Published: March 2020

AbstractTumor immunotherapies have provided clinical benefits, yet great potential remains for optimizing therapeutic effects. Here, we show that low NAD+levels restrict the function of tumor infiltrating T lymphocytes (TILs). TILs harvested from human ovarian tumor tissues showed decreased NAD+levels compared with T cells from paired peripheral blood samples. The combination of whole-genome CRISPR and large-scale metabolic inhibitor screens implicated the NAD+biosynthesis enzyme nicotinamide phosphoribosyltransferase (NAMPT) is required for T cell activation. Further isotopic labeling and LC-MS studies confirmed that NAD+depletion suppressed mitochondrial energy biosynthesis in T cells. Excitingly, NAD+supplementation significantly enhanced the tumor cell-killing efficacy of CAR-T cellsex vivo, and extended animal survive in both adoptive CAR-T model and immune checkpoint blockade treatment modelsin vivo. This study demonstrates an over-the-counter nutrient supplement NAD+could robustly boost the efficacy of T cell-based immunotherapy and provides insights into the cellular basis of T cell metabolic reprogramming in treating cancers.One Sentence SummaryNAD+supplementation during cancer immunotherapies significantly enhances T cell activation and tumor killing capacity.
K-PAM: A unified platform to distinguishKlebsiellaspecies K- and O-antigen types, model antigen structures and identify hypervirulent strains
Authors: Prasad Patro L Ponoop , Sudhakar Karpagam Uma , Rathinavelan Thenmalarchelvi 
Published: March 2020

AbstractA computational method has been developed to distinguish theKlebsiellaspecies serotypes to aid in outbreak surveillance. A reliability score (estimated based on the accuracy of a specific K-type prediction against the dataset of 141 distinct K-types) average(ARS) that reflects the specificity between theKlebsiellaspecies capsular polysaccharide biosynthesis and surface expression proteins, and their K-types has been established. ARS indicates the following order of potency in accurate serotyping: Wzx(ARS=98.5%),Wzy(ARS=97.5%),WbaP(ARS=97.2%),Wzc(ARS=96.4%),Wzb(ARS=9 4.3%),WcaJ(ARS=93.8%),Wza(ARS=79.9%) and Wzi(ARS=37.1%). Thus, Wzx, Wzy and WbaP can give more reliable K-typing compared with other proteins. A fragment-based approach has further increased the Wzi ARS from 37.1% to 80.8%. The efficacy of these 8 proteins in accurate K-typing has been confirmed by a rigorous testing and the method has been automated as K-PAM(www.iith.ac.in/K-PAM/). Testing also indicates that the use of multiple genes/proteins helps in reducing the K-type multiplicity, distinguishing the K-types that have identical K-locus(like KN3 and K35) and identifying the ancestral serotypes ofKlebsiellaspp. K-PAM has the facilities to O-type using Wzm(ARS=85.7%) and Wzt(ARS=85.7%) and identifies the hypervirulentKlebsiellaspecies by the use ofrmpA,rmpA2,iucABCD,iroBCDNandiutAmarker genes. Yet another highlight of the server is the repository of the modeled 11 O- and 79 K - antigen 3D structures.
Integrated metabolomics and proteomics of symptomatic and early pre-symptomatic states of colitis
Authors: Shimshoni Elee , Ghini Veronica , Solomonov Inna , Luchinat Claudio , Sagi Irit , Turano Paola 
Published: March 2020

AbstractTwo murine models for colitis were used to study multi-level changes and derive molecular signatures of colitis onset and development. By combining metabolomics data on tissues and fecal extracts with proteomics data on tissues, we provide a comprehensive picture of the metabolic profile of acute and chronic states of the disease, and most importantly, of two early pre-symptomatic states. We show that, increased anaerobic glycolysis, accompanied by altered TCA cycle and oxidative phosphorylation, associates with inflammation-induced hypoxia taking place in colon tissues. We also demonstrate significant changes in the metabolomic profiles of fecal extracts in different colitis states, most likely associated with the dysbiosis characteristic of colitis, as well as the dysregulated tissue metabolism. Most remarkably, strong and distinctive tissue and fecal metabolomic signatures can be detected before onset of symptoms. These results highlight the diagnostic potential of global metabolomics for inflammatory diseases.
Perceptions of organizational justice and commitment of non-family employees in family and non-family firms
Authors: Pimentel Duarte , Serras Pires Juliana , Almeida Pedro L. 
Published: March 2020

PurposeThe purpose of this paper is to explore differences between non-family employees of family and non-family firms regarding the perceptions of organizational justice and levels of organizational commitment. Moreover, focusing on non-family employees of family firms, the study assesses the relation between the perceptions of organizational justice and levels of organizational commitment. Finally, the study seeks to understand which dimension of organizational commitment (i.e. affective, continuance, or normative) is more associated with the perceptions of organizational justice of non-family employees working in family firms.Design/methodology/approachThe empirical evidence is provided by a sample of 205 Portuguese employees, 98 non-family employees of family firms, and 107 non-family firms' employees, who responded to a questionnaire that included organizational justice and commitment measures. All firms included in the sample are small-sized privately owned companies.FindingsResults show that there are no differences between non-family employees of family and non-family firms regarding the perceptions of organizational justice. However, results reveal that there are significant differences regarding the levels of organizational commitment. Furthermore, it was found that, in family firms, non-family employees' perceptions of organizational justice are positively related to the levels of commitment, especially regarding the affective dimension.Originality/valueThis paper aims to contribute to the literature by addressing two classical organizational aspects, which are yet under-researched in the comparison between family and non-family firms, while pursuing to shed some light on the relationship between the perceptions of organizational justice and levels of organizational commitment of non-family employees working in family firms.
Collaborative consumption, social distance and the extended self
Authors: Frechette Michael , Arnold Mark , Kaikati Andrew , Singh Nitish 
Published: March 2020

Purpose
This paper aims to look at the exchange context of peer-to-peer (P2P) collaborative consumption (e.g. Uber and Airbnb). Specifically, the paper examines the effect that the sharing of a personal possession, such as a car or apartment, may have on the consumer.

Design/methodology/approach
Two studies were conducted via online surveys. The surveys used vignettes that asked participants to imagine service experiences in either a P2P or a business-to-consumer (B2C) context. The participants then answered questions, including their perceptions of social closeness to the service provider, as well as willingness to pay (Study 1) and expectations of satisfaction (Study 2). The analysis used bootstrapping regression models to examine the relationships.

Findings
In both studies, the participants in the P2P conditions reported significantly greater perceived social closeness to the service provider than did those in the B2C condition. The P2P condition also resulted in significant indirect effects (i.e. mediated by social closeness) on willingness to pay (Study 1) and expectations of satisfaction (Study 2).

Originality/value
This paper extends the work on social distance to show that the effects are activated by the P2P exchange context. Also demonstrated here is that social closeness acts as an important mediator in the P2P context, affecting outcomes in the consumption and pre-consumption stages. Finally, construal level effects are extended to show that trend interpretation can be influenced by social distance.
Pay-premium for green brands: evidence from an emerging country
Authors: Akturan Ulun 
Published: March 2020

PurposeThis study aims to examine how green branding strategies affect pay-premium behaviour of consumers for high- vs low-involvement green products in an emerging country.Design/methodology/approachData were collected from 500 consumers by survey method, and structural equation modelling was run to analyse the hypotheses.FindingsConsequently, it was found that for involvement level consumers’ pay-premium behaviour was affected indirectly by perceived quality, and directly by green brand equity and brand credibility. Moreover, in addition to those factors, for low-involvement green products, performance risk and financial risk have an impact on willingness to pay more; however, for high-involvement green products, only performance risk influences the pay more behaviour of consumers.Research limitations/implicationsIn the research, two involvement levels and two brands were used. Brand names in particular may have caused a bias in the measurement. And the findings are limited by the sample, which includes respondents from an emerging country.Practical implicationsManagers should focus on green brand equity, brand quality and credibility to support willingness to pay more for green products. Moreover, they should monitor performance risk and financial risk perceptions, which may differ according to the involvement levels.Originality/valueThere is no other study, at least to the best of the author’s knowledge, testing the effects of brand-related factors on consumers’ willingness to pay-premium for green brands.
Efficacy of acitretin in the treatment of reactive neutrophilic dermatoses in adult‐onset immunodeficiency due to interferon‐gamma autoantibody
Authors: Rujiwetpongstorn Rujira , Chuamanochan Mati , Tovanabutra Napatra , Chaiwarith Romanee , Chiewchanvit Siri 
Published: March 2020

AbstractReactive neutrophilic dermatoses in adult‐onset immunodeficiency due to interferon‐γ autoantibody (AOID) are usually associated with concomitant active opportunistic infections. Data focusing on the treatment of these dermatoses with non‐immunosuppressive drugs are still lacking. The aim of this study was to assess the efficacy and safety of acitretin treatment of reactive neutrophilic dermatoses in AOID. We conducted a retrospective review of all patients with AOID who had reactive neutrophilic dermatoses and had been treated with acitretin from January 2008 to December 2018. In total, 23 patients had been diagnosed with AOID, with 27 episodes of reactive neutrophilic dermatoses (20 episodes of Sweet syndrome and seven episodes of generalized pustular eruption) and treated with acitretin. The median effective dose of acitretin was 10 mg/day. The mean initial response was 5.6 ± 2.3 days. The rash had almost or completely cleared within 2 weeks in 70.4% of patients. One case had developed a reversible acitretin‐induced liver injury with hepatocellular pattern. The median total duration of treatment was 3 months. In conclusion, this study demonstrates the potential role of acitretin as one of the treatments of choice for reactive neutrophilic dermatoses in AOID, attributable to its favorable response and good tolerability.
Case series of cutaneous T‐cell lymphomas treated with bexarotene‐based therapy
Authors: Fujimura Taku , Sato Yota , Tanita Kayo , Amagai Ryo , Shimauchi Takatoshi , Ogata Dai , Fukushima Satoshi , Miyashita Azusa , Fujisawa Yasuhiro , Kambayashi Yumi , Aiba Setsuya 
Published: March 2020

AbstractBexarotene is useful for both early and advanced cutaneous T‐cell lymphoma (CTCL), and is sometimes applied to ultraviolet‐tolerant early CTCL patients as one of the first‐line therapies in the real world. However, continuous administration of bexarotene is sometimes difficult because of its adverse events (AE). Development of an appropriate protocol for bexarotene that can induce a consistent response for CTCL without severe AE (SAE) is needed. We retrospectively investigated 29 Japanese cases of CTCL and evaluated the efficacy of treatment and incident ratios of all AE and SAE. Objective response rate (ORR) for the overall cohort was 65.5%. ORR of the 300 mg/m2 cohort (conventional dose) was 76.2%, while that of the 150–300 mg/body (low dose) with narrowband ultraviolet B light (NBUVB) cohort was 37.5%. Mean event‐free survival was 10.0 months for all patients, 6.7 months for the bexarotene conventional‐dose cohort and 19.1 months for the low‐dose with NBUVB cohort. The incident ratio of total SAE for all patients was 20.7%. The incident ratio of total SAE was 23.8% for the conventional‐dose cohort and 12.5% for the low‐dose with NBUVB cohort. Our present study suggests that low‐dose bexarotene plus NBUVB therapy is well‐tolerated and could be one of the optimal therapies for advanced CTCL.
Comparative study on preoperative localization techniques using microcoil and hookwire by propensity score matching
Authors: Yang Feng , Zhao Hui , Sui Xizhao , Zhang Xugang , Sun Zewen , Zhao Xiaoyi , Wang Jun 
Published: March 2020

AbstractBackgroundThe purpose of this study was to compare the efficacy and safety of two preoperative pulmonary nodule localization techniques using microcoil and hookwire.MethodsA total of 307 patients with 324 pulmonary nodules were included in the study from March 2012 to October 2016 in two medical centers. Baseline data, positioning operation data, success rate, complications, surgery and pathological results were statistically analyzed. Complications were used as the dependent variables, whereas others were used as covariates for the propensity score matching of the two groups. Statistical analyses were performed to compare the success rate and complication rate of the matched groups.ResultsThere were 218 lesions in the microcoil group and 106 nodules in the hookwire group. There were no significant differences in gender, age and the location of nodules between the two groups. The diameters of the nodules were smaller (8.2 ± 3.5 mm vs. 10.7 ± 4.3 mm) and solid nodules were fewer (11.5% vs. 26.4%) in the microcoil group. The complication rate of the two groups was not statistically significant. After propensity score matching, 71 patients in each group were successfully matched. We found that the success rate was higher (97.2% vs. 94.4%) and the incidence of complications was lower (31% vs. 15.5%) in the microcoil group.ConclusionsBoth techniques have been shown to be effective in preoperative localization of tiny pulmonary nodules. The method of microcoil localization has more advantages in clinical application.Key pointsComparison of the efficacy and safety of two methods in preoperative pulmonary nodule localization in order to determine the optimal method.
Systematic review and meta‐analysis of the association between diverticulosis of the appendix and neoplasia
Authors: Lim Christopher Seng Hong , Cheah Sarah Yi‐Lin , Kwok Allan Mun Fai , Ravindran Praveen , Chan Daniel Leonard 
Published: March 2020

AbstractBackgroundDiverticula of the appendix (DA) are infrequent and their clinical implications are often overlooked. Several studies have found a significantly increased prevalence of neoplasms in appendiceal specimens with diverticula. Despite the potential clinical implications, there is a paucity of literature. A systematic review and meta‐analysis was performed to evaluate the prevalence of DA and its association with neoplasia.MethodsA systematic search of literature (Cochrane, EMBASE, PubMed and Medline) reporting the prevalence of DA and association with neoplasia was performed in November 2019. Relevant articles were assessed in accordance with the PRISMA guidelines. Risk of bias assessment was carried out using modified Newcastle–Ottawa scale. Meta‐analysis with risk ratio and random‐effects model was performed using RevMan.ResultsThe initial search identified 1122 potential articles of which 11 were appropriate for quantitative analysis. The prevalence rate of DA was 1.74%. The mean age of patients with DA and those without DA was 41.2 and 33.9 years, respectively. The ratio of male to female was 1.8:1. The prevalence of neoplasia in specimens without DA versus those with DA was 1.28% and 26.94%, respectively. Only four studies addressed the prevalence of locoregional neoplasia in the setting of DA compared to control. Meta‐analysis with random‐effects model demonstrated that pooled risk ratio was 25.46 (95% confidence interval 12.77–50.75, P < 0.00001).ConclusionThe strong association with neoplasia in this meta‐analysis reinforces the clinical significance of DA. Surgeons, pathologists and radiologists should be mindful of this uncommon pathology and consider individualized patient management, until further evidence can direct clinical guidelines for the management of patients with DA.
Children’s Intergroup Attitudes: Insights From Iran
Authors: Yazdi Haleh , Barner David , Heyman Gail D. 
Published: March 2020

Children generally favor individuals in their own group over others, but it is unclear which dimensions of the out‐group affect this bias. This issue was investigated among 7‐ to 8‐year‐old and 11‐ to 12‐year‐old Iranian children (N = 71). Participants evaluated in‐group members and three different out‐groups: Iranian children from another school, Arab children, and children from the United States. Children’s evaluations closely aligned with the perceived social status of the groups, with Americans viewed as positively as in‐group members and Arabs viewed negatively. These patterns were evident on measures of affiliation, trust, and loyalty. These findings, which provide some of the first insights into the social cognition of Iranian children, point to the role of social status in the formation of intergroup attitudes.
Preschool Verbal and Nonverbal Ability Mediate the Association Between Socioeconomic Status and School Performance
Authors: von Stumm Sophie , Rimfeld Kaili , Dale Philip S. , Plomin Robert 
Published: March 2020

We compared the extent to which the long‐term influence of family socioeconomic status (SES) on children's school performance from age 7 through 16 years was mediated by their preschool verbal and nonverbal ability. In 661 British children, who completed 17 researcher‐administered ability tests at age 4.5 years, SES correlated more strongly with verbal than nonverbal ability (.39 vs. .26). Verbal ability mediated about half of the association between SES and school performance at age 7, while nonverbal ability accounted for a third of the link. Only SES, but not verbal or nonverbal ability, was associated with changes in school performance from age 7 to 16. We found that SES‐related differences in school performance are only partly transmitted through children's preschool verbal abilities.
Lack of evidence of a Pleistocene migratory switch in current bird long‐distance migrants between Eurasia and Africa
Authors: Ponti Raquel , Arcones Angel , Ferrer Xavier , Vieites David R. 
Published: March 2020

AbstractAimDuring the Plio‐Pleistocene, glacial cycles shaped Northern Hemisphere species' distributions causing range contractions followed by interglacial expansions. In migratory bird species, climatic changes could result in a rapid reshaping of their ranges and/or migratory behaviour, given their dispersal capacity. In this context, it has been suggested that long‐distance North American migratory species could have lost their migratory condition during cold glacial periods, regaining it later in warmer periods. Here, we explored this hypothesis for extant Eurasian‐African migratory bird species.LocationEurasia and Africa.TaxonMigratory birds.MethodsWe used Species Distribution Models (SDMs) to infer the present and Last Glacial Maximum (LGM) potential distribution of 81 Trans‐Saharan migratory bird species, and reviewed the available bird fossil record for the Plio‐Pleistocene covering Eurasia and Africa.ResultsSDMs predicted a reduction of the northern edges of the breeding ranges during the LGM compared to the present. However, the current wintering ranges were somewhat similar in the Pleistocene, with the Saharan desert belt gap being always present through time, not overlapping with their breeding ranges. The fossil record also supports the persistence of migration during the Pleistocene.Main conclusionsThe palaeo‐distributions and absence of medullary bone in Pleistocene fossils from wintering Euro‐African migratory species confirm that they were migratory, providing independent support for our models. The hypothesis of the loss of migratory behaviour in these species during the Pleistocene is not supported. Furthermore, the differences in migratory species from Eurasia‐Africa and the Americas can be influenced by geographical differences, the persistence of the Mediterranean basin as climatically suitable area during glaciations and the existence of the Saharan belt.