bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Pattern Classification Can Distinguish Gender Identity Subtypes from Behavior and Brain Imaging
Authors: Clemens Benjamin , Derntl Birgit , Smith Elke , Junger Jessica , Neulen Josef , Mingoia Gianluca , Schneider Frank , Abel Ted , Bzdok Danilo , Habel Ute 
Published: October 2019

AbstractThe exact neurobiological underpinnings of gender identity (i.e., the subjective perception of oneself belonging to a certain gender) still remain unknown. Combining both resting-state functional connectivity and behavioral data, we examined gender identity in cisgender and transgender persons using a data-driven machine learning strategy. Intrinsic functional connectivity and questionnaire data were obtained from cisgender (men/women) and transgender (trans men/trans women) individuals. Machine learning algorithms reliably detected gender identity with high prediction accuracy in each of the four groups based on connectivity signatures alone. The four normative gender groups were classified with accuracies ranging from 48% to 62% (exceeding chance level at 25%). These connectivity-based classification accuracies exceeded those obtained from a widely established behavioral instrument for gender identity. Using canonical correlation analyses, functional brain measurements and questionnaire data were then integrated to delineate nine canonical vectors (i.e., brain-gender axes), providing a multilevel window into the conventional sex dichotomy. Our dimensional gender perspective captures four distinguishable brain phenotypes for gender identity, advocating a biologically grounded reconceptualization of gender dimorphism. We hope to pave the way towards objective, data-driven diagnostic markers for gender identity and transgender, taking into account neurobiological and behavioral differences in an integrative modeling approach.
Resistance-Guided Antimicrobial Therapy Using Doxycycline–Moxifloxacin and Doxycycline–2.5 g Azithromycin for the Treatment of Mycoplasma genitalium Infection: Efficacy and Tolerability
Authors: Durukan Duygu , Read Tim R H , Murray Gerald , Doyle Michelle , Chow Eric P F , Vodstrcil Lenka A , Fairley Christopher K , Aguirre Ivette , Mokany Elisa , Tan Lit Y , Chen Marcus Y , Bradshaw Catriona S 
Published: October 2019

Abstract

Background
Macrolide resistance in Mycoplasma genitalium (MG) exceeds 50% in many regions, and quinolone resistance is increasing. We recently reported that resistance-guided therapy (RGT) using doxycycline followed by sitafloxacin or 2.5 g azithromycin cured 92% and 95% of macrolide-resistant and macrolide-susceptible infections, respectively. We present data on RGT using doxycycline–moxifloxacin, the regimen recommended in international guidelines, and extend data on the efficacy of doxycycline–2.5 g azithromycin and de novo macrolide resistance.

Methods
Patients attending Melbourne Sexual Health Centre between 2017 and 2018 with sexually transmitted infection syndromes were treated with doxycycline for 7 days and recalled if MG-positive. Macrolide-susceptible cases received 2.5 g azithromycin (1 g, then 500 mg daily for 3 days), and resistant cases moxifloxacin (400 mg daily, 7 days). Test of cure was recommended 14–28 days post-antimicrobials.

Results
There were 383 patients (81 females/106 heterosexual males/196 men who have sex with men) included. Microbial cure following doxycycline–azithromycin was 95.4% (95% confidence interval [CI], 89.7–98.0) and doxycycline–moxifloxacin was 92.0% (95% CI, 88.1–94.6). De novo macrolide resistance was detected in 4.6% of cases. Combining doxycycline–azithromycin data with our prior RGT study (n = 186) yielded a pooled cure of 95.7% (95% CI, 91.6–97.8). ParC mutations were present in 22% of macrolide-resistant cases.

Conclusions
These findings support the inclusion of moxifloxacin in resistance-guided strategies and extend the evidence for 2.5 g azithromycin and presumptive use of doxycycline. These data provide an evidence base for current UK, Australian, and European guidelines for the treatment of MG.
A simple modification of dialysate potassium: its impact on plasma potassium concentrations and the electrocardiogram
Authors: Delanaye Pierre , Krzesinski François , Dubois Bernard E , Delcour Alexandre , Robinet Sébastien , Piette Caroline , Krzesinski Jean-Marie , Lancellotti Patrizio 
Published: October 2019

AbstractBackgroundSudden death is frequent in haemodialysis (HD) patients. Both hyperkalaemia and change of plasma potassium (K) concentrations induced by HD could explain this. The impact of increasing dialysate K by 1 mEq/L on plasma K concentrations and electrocardiogram (ECG) results before and after HD sessions was studied.MethodsPatients with pre-dialysis K &gt;5.5 mEq/L were excluded. ECG and K measurements were obtained before and after the first session of the week for 2 weeks. Then, K in the dialysate was increased (from 1 or 3 to 2 or 4 mEq/L, respectively). Blood and ECG measurements were repeated after 2 weeks of this change.ResultsTwenty-seven prevalent HD patients were included. As expected, a significant decrease in K concentrations was observed after the dialysis session, but this decrease was significantly lower after the switch to an increased dialysate K. The pre-dialysis K concentrations were not different after changing, but post-dialysis K concentrations were higher after switching (P &lt; 0.0001), with a lower incidence of post-dialysis hypokalaemia. Regarding ECG, before switching, the QT interval (QT) dispersion increased during the session, whereas no difference was observed after switching. One week after switching, post-dialysis QT dispersion [38 (34–42) ms] was lower than post-dialysis QT dispersion 2 weeks and 1 week before switching [42 (38–57) ms, P = 0.0004; and 40 (35–50) ms, P = 0.0002].ConclusionsA simple increase of 1 mEq/L of K in the dialysate is associated with a lower risk of hypokalaemia and a lower QT dispersion after the dialysis session. Further study is needed to determine if such a strategy is associated with a lower risk of sudden death.
Physicians as Advisors Not Leaders of Multidisciplinary Teams: A Qualitative Study of an Innovative Practice
Authors: Mendelev Eliezer , Mazumdar Madhu , Keefer Laurie , Gorbenko Ksenia 
Published: October 2019

Abstract

Background and Aims
As various models of team-based chronic disease management have proliferated, physicians have assumed the leadership role in most of them. However, physician time is costly, and regular attendance of team meetings adds another task to a long list of responsibilities. This is the first study to explore the role of physicians as advisors rather than leaders of a multidisciplinary team.

Methods
We conducted an exploratory qualitative research study of a subspecialty medical home located within a tertiary academic medical center that cares for highly complex pediatric and adult patients with inflammatory bowel diseases. The medical home team consists of a psychologist, dieticians, social workers, a clinical pharmacist, and nurses. No physicians regularly attend team meetings. We conducted semi-structured interviews with nonphysician team members (N = 11) and gastroenterologists (N = 6). Two authors coded interview transcripts in NVivo 11 for themes related to “physician role” using an inductive qualitative analysis approach.

Results
Nonphysician participant believed gastroenterologists did not need to attend weekly meetings. Having only nonphysician personnel in the room made them feel more empowered to openly express their views. Gastroenterologists expressed interest in attending one or more, but not all meetings, in order to better understand the process of the team and desired a more formal feedback loop for staying informed about their patients’ progress.

Conclusions
Our findings suggest that gastroenterologist participation may not require regular attendance of team meetings. Team meeting consisting of nonphysician providers would result in cost savings and may empower nonphysician providers.
The effect of scissor-type versus non-scissor-type knives on the technical outcomes in endoscopic submucosal dissection for superficial esophageal cancer: a multi-center retrospective study
Authors: Esaki Mitsuru , Hayashi Yasuyo , Ikehara Hisatomo , Ihara Eikichi , Horii Toshiki , Tamura Yu , Ichijima Ryoji , Yamakawa Shun , Irie Akira , Shibuya Hitoshi , Suzuki Sho , Kusano Chika , Minoda Yosuke , Akiho Hirotada , Ogawa Yoshihiro , Gotoda Takuji 
Published: October 2019

SUMMARY
The Clutch Cutter was invented as a scissor-type knife for endoscopic submucosal dissection (ESD) of gastrointestinal neoplasms. ESD with the scissor-type knife (ESD-S) may be considered a technically easier procedure than ESD with non-scissor-type knives (ESD-NS). Therefore, this study aimed to compare the technical outcomes of ESD-S with those of ESD-NS for superficial esophageal cancer. This was a multicenter retrospective study. Patients with superficial esophageal cancer treated with ESD between October 2015 and March 2018 at three hospitals were retrospectively reviewed. The ESD-S group had 48 patients and the ESD-NS group had 114 patients. A propensity score matching analysis was performed to compensate for the confounding bias between both groups. Multivariate analyses and propensity score matching were used to adjust for age, sex, the tumor size, tumor location, tumor depth, degree of tumor circumference, operator level, usage of the traction method, and the sedation method. The primary outcome was the procedure time of the ESD. Secondary outcomes were the rate of en-bloc/complete resection and the rate of complications including perforation, delayed bleeding, and stricture. Propensity score matching analysis provided 36 matched pairs. Median procedure time in the ESD-S group was significantly shorter than that in the ESD-NS group (44.0 min vs. 66.5 min, P = 0.020). In addition, the treatment outcomes were similar in both groups (en-bloc resection: 100% vs. 97.2%, P = 1; complete resection: 88.9% vs. 86.1%, P = 1; curative resection: 80.6% vs. 77.8%, P = 1; perforation: 0% vs. 5.6%, P = 0.49; delayed bleeding: 0% in both groups; stricture: 2.8% vs. 8.3%, P = 0.61). ESD-S was associated with a shorter procedure time than ESD-NS, without an increase in the incidence of complications. Therefore, the scissor-type knife should be considered as an endo-knife for ESD of superficial esophageal cancers.
Utility of stent double palliation for esophageal cancer with airway involvement: the extremis of care
Authors: Roseira J , Mão de Ferro S , Moleiro J , Currais P , Lemos J , Dionísio J , Ferreira S , Rosa I , Lage P , Szantho A , Duro da Costa J , Dias Pereira A 
Published: October 2019

SUMMARY
Primary esophageal cancer (EC) frequently presents as a locally advanced disease with airway involvement. Placement of combined esophageal and airway stents has been reported in small series to be an effective palliation strategy. Our aims are to present the largest cohort of EC patients who underwent double stent palliation and to evaluate the safety and efficacy of this approach. Longitudinal cohort study of patients with primary EC undergoing two-stage esophageal and airway stent placement at an oncology referral institute (January 2000–January 2019). Assessments: baseline demographics and clinical variables; baseline and week 2 dysphagia, dyspnea and performance status (PS) scores; baseline and week 8 body mass index (BMI); overall survival. Statistics: paired t-test; Kaplan–Meier method. Seventy patients (89% men, mean age 60.20 ± 8.41) underwent double stenting. Esophageal stent was placed for esophageal stenosis and dysphagia (n = 41; placement of a second stent due to recurrence in nine cases) or esophagorespiratory fistulas (ERFs) (n = 29); airway stent was required for ERF sealing (n = 29 + 7 new ERFs after esophageal stent) and to ensure airway patency due to malignant stenosis (n = 29; placement of a second stent due to recurrence in 13 cases) or compression (n = 5). There were 13, endoscopically managed, major complications after esophageal stent [hemorrage (n = 1), migration (n = 5) and new fistulas (n = 7)]. As for airway stents, four major complications were recorded [hemorrage (n = 1) and three deaths due to respiratory infection and ultimately respiratory failure 3–7 days after the procedure]. Overall, patients showed significant improvement in dysphagia and dyspnea symptoms (3.21 vs. 1.31 e 15.56 vs. 10.87; P &lt; 0.001). There was a PS improvement for 89.2% (n = 58) of the patients. BMI at week 8 was comparable to baseline records. Mean survival was 137.83 ± 24.14 days (95% CI: 90.51–185.15). Survival was longer for better PS (PS1, 249.95 days; PS2, 83.74 days; PS3, 22.43 days; PS4, 30.00 days). This is the largest comprehensive assessment of double stent palliation in advanced incurable EC. For both esophageal or airway stenosis and fistula, placement of combined esophageal and airway stents was a feasible, effective, fast-acting and safe modality for symptom palliation and body mass maintenance. Patient autonomy followed symptom improvement. Since it is impossible to provide treatment for cure in most of these cases, this endoscopic strategy, performed in differentiated units with the required technical capacity, may guarantee treatment for the relief of palliative EC.
Myocardial fibrosis in arrhythmogenic cardiomyopathy: a genotype–phenotype correlation study
Authors: Segura-Rodríguez Diego , Bermúdez-Jiménez Francisco José , Carriel Víctor , López-Fernández Silvia , González-Molina Mercedes , Oyonarte Ramírez José Manuel , Fernández-Navarro Laura , García-Roa María Dolores , Cabrerizo Elisa M , Durand-Herrera Daniel , Alaminos Miguel , Campos Antonio , Macías Rosa , Álvarez Miguel , Tercedor Luis , Jiménez-Jáimez Juan 
Published: October 2019

Abstract

Aims
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a life-threatening entity with a highly heterogeneous genetic background. Cardiac magnetic resonance (CMR) imaging can identify fibrofatty scar by late gadolinium enhancement (LGE). Our aim is to investigate genotype–phenotype correlation in ARVC/D mutation carriers, focusing on CMR-LGE and myocardial fibrosis patterns.

Methods and results
A cohort of 44 genotyped patients, 33 with definite and 11 with borderline ARVC/D diagnosis, was characterized using CMR and divided into groups according to their genetic condition (desmosomal, non-desmosomal mutation, or negative). We collected information on cardiac volumes and function, as well as LGE pattern and extension. In addition, available ventricular myocardium samples from patients with pathogenic gene mutations were histopathologically analysed. Half of the patients were women, with a mean age of 41.6 ± 17.5 years. Next-generation sequencing identified a potential pathogenic mutation in 71.4% of the probands. The phenotype varied according to genetic status, with non-desmosomal male patients showing lower left ventricular (LV) systolic function. LV fibrosis was similar between groups, but distribution in non-desmosomal patients was frequently located at the posterolateral LV wall; a characteristic LV subepicardial circumferential LGE pattern was significantly associated with ARVC/D caused by desmin mutation. Histological analysis showed increased fibrillar connective tissue and intercellular space in all the samples.

Conclusion
Desmosomal and non-desmosomal mutation carriers showed different morphofunctional features but similar LV LGE presence. DES mutation carriers can be identified by a specific and extensive LV subepicardial circumferential LGE pattern. Further studies should investigate the specificity of LGE in ARVC/D.
Reducing distance through online international collaboration
Authors: Schreiber Brooke R , Jansz Mihiri 
Published: October 2019

Abstract
Online and hybrid courses offer many benefits for ESL teacher education, but can be hampered by ‘transactional distance’, a lack of interpersonal closeness which can cause misunderstanding and disengagement. This article describes a pedagogical project in which in-service teachers studying in a distance-learning MA TESL programme in Sri Lanka participated in an asynchronous discussion forum with peers from a university in New York City to discuss varieties of World Englishes. The project increased dialogue between learners, and between learners and the instructor, providing space for informal interactions through text, images, and video, as well as multiple methods for responding to feedback, ultimately reducing transactional distance. This article discusses the benefits of the project as well as the pedagogical and technological challenges, offering suggestions for other MA TESL educators about implementing such collaborations.
Cloning and characterization of a thermostable glutathione reductase from a psychrophilic Arctic bacterium Sphingomonas sp
Authors: VuThi Hai , Jang Sei-Heon , Lee ChangWoo 
Published: October 2019

ABSTRACT
Glutathione reductase is an important oxidoreductase that helps maintain redox homeostasis by catalyzing the conversion of glutathione disulfide to glutathione using NADPH as a cofactor. In this study, we cloned and characterized a glutathione reductase (hereafter referred to as SpGR) from Sphingomonas sp. PAMC 26621, an Arctic bacterium. SpGR comprises 449 amino acids, and functions as a dimer. Surprisingly, SpGR exhibits characteristics of thermophilic enzymes, showing optimum activity at 60°C and thermal stability up to 70°C with ∼50% residual activity at 70°C for 2 h. The amino acid composition analysis of SpGR showed a 1.9-fold higher Arg content (6%) and a 2.7-fold lower Lys/Arg ratio (0.75) compared to the Arg content (3.15%) and the Lys/Arg ratio (2.01) of known psychrophilic glutathione reductases. SpGR also exhibits its activity at 4°C, and circular dichroism and fluorescence spectroscopy results indicate that SpGR maintains its secondary and tertiary structures within the temperature range of 4–70°C. Taken together, the results of this study indicate that despite its origin from a psychrophilic bacterium, SpGR has high thermal stability. Our study provides an insight into the role of glutathione reductase in maintaining the reducing power of an Arctic bacterium in a broad range of temperatures.
Prolyl Hydroxylase Inhibition Mitigates Pouchitis
Authors: Harnoss Jonathan M , Gebhardt Jasper M , Radhakrishnan Praveen , Leowardi Christine , Burmeister Julius , Halligan Doug N , Yuan Shuai , Kennel Kilian B , Strowitzki Moritz J , Schaible Anja , Lasitschka Felix , Taylor Cormac T , Schneider Martin 
Published: October 2019

Abstract

Background
Pouchitis is the most common long-term complication after restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) for ulcerative colitis (UC) or familial adenomatous polyposis (FAP), which can eventually progress to pouch failure, necessitating permanent stoma construction. Hypoxia-inducible transcription factor prolyl hydroxylase–containing enzymes (PHD1, PHD2, and PHD3) are molecular oxygen sensors that control adaptive gene expression through hypoxia-inducible factor (HIF). Emerging evidence supports PHDs as being therapeutic targets in intestinal inflammation. However, pharmacological inhibition of PHDs has not been validated as a treatment strategy in pouchitis.

Methods
PHD1-3 mRNA and protein expression were analyzed in mucosal pouch and prepouch ileal patient biopsies. After establishment of a preclinical IPAA model in rats, the impact of the pan-PHD small-molecule inhibitor dimethyloxalylglycine (DMOG) on dextran sulfate sodium (DSS)–induced pouchitis was studied. Clinical and molecular parameters were investigated.

Results
PHD1, but not PHD2 or PHD3, was overexpressed in pouchitis in biopsies of patients with IPAA for UC but not FAP. In addition, PHD1 expression correlated with disease activity. DMOG treatment profoundly mitigated DSS-induced pouchitis in a rodent IPAA model. Mechanistically, DMOG restored intestinal epithelial barrier function by induction of tight junction proteins zona occludens-1 and claudin-1 and alleviation of intestinal epithelial cell apoptosis, thus attenuating pouch inflammation.

Conclusions
Together, these results establish a strong therapeutic rationale for targeting PHD1 with small-molecule inhibitors in pouchitis after IPAA for UC.
One-bit compressed sensing with partial Gaussian circulant matrices
Authors: Dirksen Sjoerd , Jung Hans Christian , Rauhut Holger 
Published: October 2019

AbstractIn this paper we consider memoryless one-bit compressed sensing with randomly subsampled Gaussian circulant matrices. We show that in a small sparsity regime and for small enough accuracy $\delta$, $m\simeq \delta ^{-4} s\log (N/s\delta )$ measurements suffice to reconstruct the direction of any $s$-sparse vector up to accuracy $\delta$ via an efficient program. We derive this result by proving that partial Gaussian circulant matrices satisfy an $\ell _1/\ell _2$ restricted isometry property property. Under a slightly worse dependence on $\delta$, we establish stability with respect to approximate sparsity, as well as full vector recovery results, i.e., estimation of both vector norm and direction.
Criteria for Embedded Eigenvalues for Discrete Schrödinger Operators
Authors: Liu Wencai 
Published: October 2019

Abstract
In this paper, we consider discrete Schrödinger operators of the form, $$\begin{equation*} (Hu)(n) = u({n+1})+u({n-1})+V(n)u(n). \end{equation*}$$We view $H$ as a perturbation of the free operator $H_0$, where $(H_0u)(n)= u({n+1})+u({n-1})$. For $H_0$ (no perturbation), $\sigma _{\textrm{ess}}(H_0)=\sigma _{\textrm{ac}}(H)=[-2,2]$ and $H_0$ does not have eigenvalues embedded into $(-2,2)$. It is an interesting and important problem to identify the perturbation such that the operator $H_0+V$ has one eigenvalue (finitely many eigenvalues or countable eigenvalues) embedded into $(-2,2)$. We introduce the almost sign type potentials and develop the Prüfer transformation to address this problem, which leads to the following five results.
1: We obtain the sharp spectral transition for the existence of irrational type eigenvalues or rational type eigenvalues with even denominators.
2: Suppose $\limsup _{n\to \infty } n|V(n)|=a&lt;\infty .$ We obtain a lower/upper bound of $a$ such that $H_0+V$ has one rational type eigenvalue with odd denominator.
3: We obtain the asymptotical behavior of embedded eigenvalues around the boundaries of $(-2,2)$.
4: Given any finite set of points $\{ E_j\}_{j=1}^N$ in $(-2,2)$ with $0\notin \{ E_j\}_{j=1}^N+\{ E_j\}_{j=1}^N$, we construct the explicit potential $V(n)=\frac{O(1)}{1+|n|}$ such that $H=H_0+V$ has eigenvalues $\{ E_j\}_{j=1}^N$.
5: Given any countable set of points $\{ E_j\}$ in $(-2,2)$ with $0\notin \{ E_j\}+\{ E_j\}$, and any function $h(n)&gt;0$ going to infinity arbitrarily slowly, we construct the explicit potential $|V(n)|\leq \frac{h(n)}{1+|n|}$ such that $H=H_0+V$ has eigenvalues $\{ E_j\}$.
Quantum Variance for Eisenstein Series
Authors: Huang Bingrong 
Published: October 2019

Abstract
In this paper, we prove an asymptotic formula for the quantum variance for Eisenstein series on $\operatorname{PSL}_2(\mathbb{Z})\backslash \mathbb{H}$. The resulting quadratic form is compared with the classical variance and the quantum variance for cusp forms. They coincide after inserting certain subtle arithmetic factors, including the central values of certain L-functions.