bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Pharmacology-Based Study of Active Ingredients and Mechanisms of Compound Xuanju for Rheumatoid Arthritis
Authors: Meng Fuxue , Tao Xiaomai , Li Longkuan , Yang Xin 
Published: November 2020

Objective: Compound Xuanju has good effects in treating rheumatoid arthritis (RA), but its composition is complex, and its active ingredients and mechanism have not been fully defined. In this study, the active ingredients and mechanism of compound Xuanju for the treatment of RA were explored through network pharmacological methods. Methods: TCMSP and TCMID, Pubmed, CNKI, Wanfang, and VIP databases were used to screen, select active pharmaceutical ingredients and targets; Drugbank disease target screening database, GeneCards database, Therapeutic The Target Database (TTD) database and DisGeNET database were used to collect RA targets, and OmicShare was used to screen compound Xuanju and RA for common targets and construct a Venn diagram. A protein target database String was used to construct a common target interaction network. OmicShare mapping software builds a "drug-active ingredient-target" network and analyzes their associations. DAVID online software performs gene annotation (GO) and KEGG pathway enrichment analysis on key targets. Results: A total of 73 effective ingredients of compound Xuanju were obtained, and corresponding to 229 targets; 2337 targets for RA. 155 key targets for potential active ingredients of compound Xuanju predicted therapeutic effect of RA, the key targets map 55 active ingredients of compound Xuanju capsules. These targets mainly involve signaling pathways such as Toll-like receptor signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, and TNF signaling pathway acting on RA. Conclusion: Compound Xuanju may via its potential 55 active ingredients act on 155 targets to treat RA through Toll-like receptor signaling pathway, PI3K-Akt signaling pathway, NF-κB signaling pathway, HIF-1 signaling pathway and TNF signaling pathway. This study lays the theoretical basis for the widespread application of compound Xuanju in clinical practice.
Benign Familial Fleck Retina
Authors: Sangoram Rohini , Karambelkar V. H. , Paranjpe Gaurav 
Published: November 2020

Familial fleck retina is a rare inherited retinal disease. Sabel Aish & Dajani (1980) first reported ocular findings in seven of 10 siblings in one Arab family. It is an autosomal-recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiological deficits . Affected individuals are asymptomatic with a large number of yellow−white flecks of variable size and shape in the midperipheral to far peripheral retina, but did not have any ocular complaints such as loss of visual acuity (VA), impaired visual fields and dark adaptation disturbances. Fluorescein angiograms documented an irregular and spotty hyperfluorescence throughout the retina (sparing the macula). This report discusses a case of 22 year old female of both eye Benign familial fleck retina.
Role of No Hydro Phacoemulsification Technique in Management of Posterior Polar Cataract
Authors: Paranjpe Dr. Gaurav , Sangoram Dr. Rohini , Damle Dr. Devika 
Published: November 2020

Posterior polar cataracts (PPC) have always been a challenge for cataract surgeons due to their inherently higher propensity for posterior capsule rupture. Over the years, several technical modifications in cataract surgery have been suggested to enhance safety and reduce the percentage of posterior capsule rupture rates in these posterior polar cataracts. This retrospective study tries to present the role and complications of no hydro phacoemulsification technique in management of posterior polar cataract.
Aim: To evaluate the role of prehydro phacoemulsification and partial depth phacoemulsification with hydrodelineation in posterior polar cataract (PPC).
Method: Medical records of 100 patients with clinical diagnosis of PPC, who underwent pre hydro phacoemulsification and partial depth phacoemulsification with hydrodelineation, were retrospectively reviewed.
Results: The incidence of posterior capsule rupture (PCR) was 8% (8/100): 4 cases occurred during epinucleus removal, 3 cases occurred during IOL implantation, and 1 occurred during OVD removal after the implantation of the intraocular lens into the bag. No nucleus piece or lens materials dropped into the vitreous during cataract surgery, and no obvious postoperative complications were found during follow-up. All patients had improved best-corrected visual acuity (BCVA) 1 month postoperatively.
Conclusion: Pre hydro phacoemulsification and partial depth phacoemulsification with hydrodelineation help to reduce the incidence of PCR and achieve satisfactory postoperative outcomes.
Serological screening for Coxiella burnetii in the context of early pregnancy loss in dairy cows
Authors: Dobos Attila , Gábor György , Wehmann Enikő , Dénes Béla , Póth-Szebenyi Bettina , Kovács Áron B. , Gyuranecz Miklós 
Published: November 2020

AbstractQ fever is one of the commonest infectious diseases worldwide. A Coxiella burnetii prevalence of 97.6% has been found by ELISA and PCR tests of the bulk tank milk in dairy cattle farms of Hungary. The herd- and individual-level seroprevalence rates of C. burnetii in the examined dairy cows and farms have dramatically increased over the past ten years. Three high-producing industrial dairy farms were studied which had previously been found ELISA and PCR positive for C. burnetii by bulk tank milk testing. Coxiella burnetii was detected in 52% of the 321 cows tested by ELISA. Pregnancy loss was detected in 18% of the cows between days 29–35 and days 60–70 of gestation. The study found a higher seropositivity rate (80.5%) in the cows that had lost their pregnancy and a seropositivity of 94.4% in the first-bred cows that had lost their pregnancy at an early stage. The ELISA-positive pregnant and aborted cows were further investigated by the complement fixation test (CFT). In dairy herds an average of 66.6% individual seropositivity was detected by the CFT (Phase II) in previously ELISA-positive animals that had lost their pregnancy and 64.5% in the pregnant animals. A higher (Phase I) seropositivity rate (50.0%) was found in the cows with pregnancy loss than in the pregnant animals (38.5%). The high prevalence of C. burnetii in dairy farms is a major risk factor related to pregnancy loss.
Retrograde flushing collection and freezing of dromedary camel epididymal spermatozoa with seminal plasma
Authors: Monaco Davide , Batista Miguel , Amann Olga , Padalino Barbara , Pieters Wouter , Morelli Mariacristina , Accogli Gianluca , Desantis Salvatore , Lacalandra Giovanni Michele 
Published: November 2020

AbstractThe objectives of this study were to describe the parameters of dromedary camel epididymal spermatozoa collected by retrograde flushing (RF) technique and to evaluate the freezability of the collected sperm, diluted with and without the supplementation of seminal plasma (SP). Two experiments were conducted: in Experiment 1, ES were recovered within 6–8 h after castration; selected samples were diluted with a Tris-citrate egg-yolk glycerolated buffer and frozen. In Experiment 2, epididymides were stored for 24 h at 4 °C before RF and semen samples were frozen after dilution with a Tris-lactose egg-yolk glycerolated extender with and without 15% SP. In Experiment 1, eight semen samples were obtained from ten epididymides with a mean of 500 × 106 total spermatozoa recovered, per flushed epididymis. Mean post-thaw motility and progressive motility were 75 and 17%, respectively. In Experiment 2, 15 samples were collected, out of the 18 epididymides (mean number of collected spermatozoa: 700 × 106), and 13 of these samples were of excellent quality. Post-thaw parameters were not satisfactory but the supplementation of the freezing medium with 15% SP improved the progressive motility and kinematic parameters of the spermatozoa.
Introducing the Chinese Name-taboo Method Gaijian An expansion of recent work by Dou Huaiyong
Authors: Jianqiang Sun 
Published: November 2020

ABSTRACTThe present paper represents the first attempt to expand Dou Huaiyong’s recent contributions to the field of the Chinese name-taboo practice or bihui 避諱. Exclusively dealing with gaixing 改形 (modify the shape), a taboo method recognized only by Dou Huaiyong, the paper delves into his use of the term gaixing and a group of orthographies that might overthrow the recognition. Although it abandons the term gaixing and promotes a new phrase gaijian 改件 (modify the components), the paper finds Dou Houiyong’s core conclusion agreeable, taking gaijian as a taboo method that appeared in the year 658 by analyzing 500 stones carved between 618 and 663. While doing so, this paper introduces for the first time gaijian to the English scholarship, proposing to re-examine how the Chinese name-taboo practice developed in the early Tang dynasty.
The Story of Shunzi in Old Uyghur
Authors: Kōichi Kitsudō , Galambos Imre 
Published: November 2020

ABSTRACTThis paper identifies three manuscript fragments from Turfan as an Old Uyghur version of the story of Shunzi 舜子, a medieval Chinese narrative about Emperor Shun acting as a filial son. In China, the story was part of the lore of filial sons (xiaozi 孝子), popular throughout most of the dynastic period. Early versions of the Chinese story survive in Japan and Dunhuang, and these display obvious parallels with the Uyghur text. While this allows a positive identification of the content of the three Turfan fragments, the differences reveal that none of the known Chinese versions could have served as the source text for the translation. The Old Uyghur version, therefore, represents an otherwise unattested version of the story, which may have developed among the Uyghurs.
Development of positive psychological capital at a Roma Student College
Authors: Varga Aranka , Trendl Fanni , Vitéz Kitti 
Published: November 2020

AbstractThe aim of our study is to present different kinds of obstacles that hindered the successful educational progress of our Roma university student interviewees from disadvantaged backgrounds. The theme is equality and equity, which is examined in the context of inclusion, empowerment, resilience and intersectionality (Varga, 2017), and to investigate their effect on positive power of performance, the positive psychological capital. Our research sample consists of the community members of the diverse Roma Student College of Pécs. The studied university students are considered resilient (Masten, Herbers, Cutuli, & Lafavor, 2008), as they have overcome the hardships of their family background and learn in higher education. Our study gives an analysis of 27 life-path interviews conducted in 2017. In these life-path interviews, we have found the external sources of resilience: supportive families, models of friends and siblings, and teachers' support as well. The intrinsic changes of personality have been prominent in the narratives, which could often balance out the negative effects with the positive psychological capital. The “building blocks” of this capital (Luthans et al., 2007) can be detected at common points in walk of life interviews, such as positive self-image, motivation, goal-orientation, and conscious planning. The positive role of the Roma Student College community appeared in their narratives as a strikingly relevant factor, from which we can assume that the shared development of different “capital types” results in investments in the interiorization process of individual members.
The role of inhibitory control and decision-making in the course of Internet gaming disorder
Authors: Kräplin Anja , Scherbaum Stefan , Kraft Eva-Maria , Rehbein Florian , Bühringer Gerhard , Goschke Thomas , Mößle Thomas 
Published: November 2020

AbstractBackground and aimsInternet gaming disorder (IGD) is associated with impaired inhibitory control and more impulsive decision-making. However, it remains unclear whether these associations are cross-sectional or predictive. We aimed to test the hypotheses that lower inhibitory control and more impulsive decision-making correlate with, are predicted by and predict more time spent on gaming and higher IGD severity.MethodsA stratified convenience sample of 70 male participants (18–21 years) was recruited to achieve broad data variability for hours spent on gaming and IGD severity. In three annual assessments (T1, T2, T3), we measured gaming behaviour and IGD severity using the Video Game Dependency Scale (CSAS-II). Both gaming-related measures were correlates (T1), predictors (T2), or outcomes (T3) of inhibitory control and decision making, which were assessed at T2 using a go/no-go task and an intertemporal-choice task, respectively.ResultsHigher IGD severity at T1 predicted more impulsive decision-making at T2 (β = 0.45, 95% CI = 0.14–0.76). Lower inhibitory control at T2 predicted more hours spent on gaming at T3 (β = −0.13, 95% CI = −0.25 to −0.02). We found weak or no evidence for the other associations.Discussion and conclusionsLower inhibitory control predicts more time spent gaming, possibly due to insufficient top-down regulation of the behaviour. Impulsive decision-making is rather a consequence of IGD than a predictor, which may be due to altered reward learning. One-dimensional etiological assumptions about the relationship between neurocognitive impairments and IGD seem not to be appropriate for the complexity of the disorder.
Different cultures, similar daydream addiction? An examination of the cross-cultural measurement equivalence of the Maladaptive Daydreaming Scale
Authors: Soffer-Dudek Nirit , Somer Eli , Abu-Rayya Hisham M. , Metin Barış , Schimmenti Adriano 
Published: November 2020

AbstractBackground and aimsMaladaptive Daydreaming (MD) is a proposed mental disorder, in which absorption in rich, narrative fantasy becomes addictive and compulsive, resulting in emotional, social, vocational, or academic dysfunction. Most studies on MD were carried out on aggregated international samples, using translated versions of the Maladaptive Daydreaming Scale (MDS-16). However, it is unknown whether the properties of MD are affected by culture. Thus, we investigated the cross-cultural measurement invariance of the MDS-16.MethodsWe recruited both individuals self-identified as suffering from MD and non-clinical community participants from four countries: the USA, Italy, Turkey, and the UK (N = 1,081).ResultsConfigural invariance was shown, suggesting that the hypothesized four-factor structure of the MDS-16 (including Yearning, Impairment, Kinesthesia, and Music) holds across cultures. Metric invariance was shown for Impairment, Kinesthesia, and Music, but not for Yearning, suggesting that the psychological meaning of the latter factor may be understood differently across cultures. Scalar invariance was not found, as MD levels were higher in the USA and UK, probably due to the over-representation of English-speaking members of MD communities, who volunteered for the study.Discussion and conclusionsWe conclude that the urge to be absorbed in daydreaming and the fantasies’ comforting and addictive properties may have different meanings across countries, but the interference of MD to one’s daily life and its obstruction of long-term goals may be the central defining factor of MD.
The evolution of European bailout arrangements and its impact on sovereign bond yields in the aftermath of the euro crisis
Authors: Boros Eszter , Sztanó Gábor 
Published: November 2020

AbstractThe 2010–2012 euro crisis prompted a wave of institutional reforms in the European Economic and Monetary Union (EMU), and one of the most remarkable changes was the creation of a permanent bailout facility for troubled sovereigns. The birth of the European Stability Mechanism (ESM) in 2012 was preceded by harsh debates, reflecting a conflict between a German view of country-level responsibility and French-Italian calls for more risk sharing. These tensions have remained ever since, which was also highlighted by conflicts regarding the ESMs overhaul at the end of 2019. Concerns of Italy then drew attention to the fact that a wide range of issues prevented the community from finalizing the post-crisis structure of the eurozone. This paper focuses on the evolution of the EMU financial assistance framework up until the latest efforts for its reform. We analyse the impact of related policy announcements on changes in sovereign bond yields of Italy, Spain, Portugal and Ireland (i.e. the most vulnerable countries during the euro crisis). Our findings show that news on bailout arrangements significantly contributed to a contemporaneous moderation of periphery bond yields, especially in the case of shorter maturities. This result hints at the role of common facilities in supporting financial stability. To enhance this feature, a ‘package approach’ (i.e. multiple reforms together, as stressed by Italy) may well need to be considered. Such a broad perspective can help strengthen the euro area once the acute threat of the coronavirus pandemic is averted.
Educación inclusiva en Colombia y la Región del Caribe colombiano: Estrategias para mostrar
Authors: Reales Vega Rosario Joaquín , Berrocal Duran Juan Carlos 
Published: November 2020

El presente artículo forma parte de los resultado de un proceso de investigación llevado a cabo por el Grupo de Investigación Andrés Bello de la Corporación Universitaria Rafael Núñez CURN, cuyo objetivo general se orientó por mostrar y analizar las estrategias que en Colombia se han diseñado y actualmente se aplican para la Educación Inclusiva desde la perspectiva socio-jurídica de la filiación. De manera específica la intención del análisis se concentró en las estrategias de lo que en Colombia se viene desarrollando en materia de inclusión en el sector educativo. Para tal fin se dispuso de una serie de técnicas de recolección de información y se planteó un diseño metodológico orientado por el método inductivo, con un tipo de investigación que retomó el enfoque de los postulados de la teoría crítica.
Eficacia simbólica de la ley 1620 del 2013 sobre Sistema de Convivencia Escolar
Authors: Castro Herrera Leonel 
Published: November 2020

La Ley 1620 de 2013 creó el Sistema Nacional de Convivencia Escolar y Formación para el ejercicio de los derechos humanos, sexuales y reproductivos, reglamentada por el Decreto 1965 de esa misma anualidad. Ahora bien, el objeto central de esta disertación es profundizar las problemáticas tan complejas que pretende regular dicha norma, comprender los elementos que componen este sistema político-jurídico, establecer la efectividad de sus objetivos explícitos y analizar la eficacia simbólica de su promulgación.
Lyme borreliosis: clinical and epidemiological features of its course in the territory of large industrial center of Western Urals
Authors: Nikolenko Vera V. , Vorobyova Natalia N. , Merkuryeva Elena V. , Nikolenko Andrey V. , Suslina Olga A. 
Published: November 2020

Objective. Since the territory of the Western Urals is widely known for its high morbidity and mortality rates associated with tick-borne infections, including ixodic tick-borne borreliosis, the study was aimed at estimation of the role of specific prevention in the prevalence of ITB.
Materials and methods. A continuous retrospective clinical and laboratory analysis of 1214 adult patients admitted to Perm Regional Clinical Infectious Disease Hospital with lyme - borreliosis in 2012-2019 was carried out.
Results. The disease is registered more often in persons over 50 years old, infection mainly occurs while visiting forests and park zones that requires the use of means of protection to reduce the number of the carriers of infection. Every third patient has mixed infection, where pathogens circulating in the ticks of the given territory of the Western Urals are combined. The increase in the number of non-erythemic forms in the recent years is probably associated with the development of immunodeficiency in the population of the industrial center, as well as with the use of more sensitive and informative methods of laboratory diagnostics.
Conclusions. Specific prophylaxis is highly effective, helping to prevent infection in more than 90% of cases.
Bionic ear prosthesis: the coming future
Authors: Arutyunov S. D. , Stepanov A. G. , Elovikov A. M. , Arutyunov A. S. , Yuzhakov A. A. , Freiman V. I. , Polyakov D. I. , Astashina N. B. 
Published: November 2020

Objective. To develop the bionic ear prosthesis design and a method for its manufacture based on intellectual and medical 3D technologies.
Materials and methods. Taking into account the analysis of data from domestic and foreign literature, a bionic ear prosthesis and a device for its manufacture have been developed. During the implementation of the project, digital equipment and software were used.
The developed design of a bionic ear prosthesis consists of several components, including an auricle prosthesis and a sound processor inserted into it. This provides the functionality of remote control, configuration and wireless charging. The system is based on the principle of bone conduction. The auricle prosthesis is an external attachment device with high aesthetic characteristics, made of biocompatible materials using modern digital technologies. Built-in hearing aid, includes a microphone; a sound processor based on a digital signal component with built-in analog-to-digital and digital-to-analog converters; Bluetooth radio channel module for communication with the settings control device (Android smartphone); and an emitter of sound vibrations.
Results. The expected positive effect is to increase the effectiveness of treatment, rehabilitation and socialization of deaf and hard of hearing patients by reducing the volume of surgical intervention; prevention of postoperative complications; the use of a rational aesthetic design of the auricle epithesis made of biologically compatible materials, with an inclinated highly functional electronic hearing aid integrated with the patient's auditory environment.
Conclusions. The combination of these factors can provide a significant reduction in the terms of medical and social rehabilitation of patients of different ages. In addition to the above, a significant advantage of the developed design of a bionic prosthesis and the method of its manufacture is ease of use and economic availability.
A study on clinical profile of acute stroke
Authors: Itagi Avinash , G. Bharat , Biradarpatil Pooja , Pattanashetti Laxmi 
Published: November 2020

Background: Stroke or cerebrovascular accident is one of the leading causes of morbidity and mortality in adult life. Ischemic strokes are most common type of strokes and they account for 80-85% of cerebrovascular accidents worldwide. Hypertension, diabetes, dyslipidemia and smoking have been identified as major risk factors. Present study was undertaken to evaluate the clinical and investigation profile of different types of strokes.Methods: A total of 100 patients with brain stroke from November 2015 to October 2016 were included. Adult patients with stroke who attended the emergency department within 24 hours of attack were included. Patients with known chronic liver or kidney diseases, transient ischemic attack, active infections, history of neoplasia and alcoholic patients were excluded from the study. A thorough physical examination was conducted and stroke was defined as per World Health Organization criteria. Blood investigations were done including Magnetic resonance imaging and computed tomography scan. The data obtained was coded and entered into Microsoft excel worksheet. The data was analyzed using SPSS statistics software version 20.0. Results: Majority of the patients (71.00%) were males and 29.0% of the patients were females. Most of the patients were aged between 61 to 70 years (27.00%). Most of the patients had ischaemic stroke (80.00%) followed by haemorrhagic stroke (20%).Conclusions: Ischemic stroke is the more common as compared to hemorrhagic stroke. Detection of vascular risk factors and primary prevention measures should be initiated during late adolescence or early adulthood.