bluuebunny/crossref_metadata_2025_split huggingface dataset:
The endosomal protein sorting nexin 4 is a novel synaptic protein
Authors: Vazquez-Sanchez Sonia , Gonzalez-Lozano Miguel A. , Walfenzao Alexarae , Li Ka Wan , van Weering Jan R.T. 
Published: December 2019

ABSTRACTSorting nexin 4 (SNX4) is an evolutionary conserved protein that mediates recycling from the endosomes back to the plasma membrane in yeast and mammalian cells. SNX4 is expressed in the brain, but its neuronal localization and function have not been addressed. Using a new antibody, endogenous neuronal SNX4 co-localized with both early and recycling endosomes, similar to the reported localization of SNX4 in non-neuronal cells. Neuronal SNX4 was accumulated in synapses, and immuno-electron microscopy revealed that SNX4 was predominantly localized to presynaptic terminals. Acute depletion of neuronal SNX4 using independent shRNAs did not affect the levels of the canonical SNX4-cargo transferrin receptor. Explorative mass spectrometry showed that each SNX4-targetted shRNA resulted in a reproducible and distinct proteome and that synaptic communication-related proteins were downregulated upon expression of the three shRNAs. The identification of SNX4 as a novel synaptic protein indicates a selective demand for SNX4 dependent sorting in synapses.
Calling Somatic SNVs and Indels with Mutect2
Authors: Benjamin David , Sato Takuto , Cibulskis Kristian , Getz Gad , Stewart Chip , Lichtenstein Lee 
Published: December 2019

AbstractMutect2 is a somatic variant caller that uses local assembly and realignment to detect SNVs and indels. Assembly implies whole haplotypes and read pairs, rather than single bases, as the atomic units of biological variation and sequencing evidence, improving variant calling. Beyond local assembly and alignment, Mutect2 is based on several probabilistic models for genotyping and filtering that work well with and without a matched normal sample and for all sequencing depths.
Residents vulnerability analysis and explanation of development-induced disasters in a Sub-Saharan African city
Authors: Okunola Olasunkanmi Habeeb 
Published: December 2019

Purpose
The purpose of this paper is to identify and analyze indicators for measuring residents’ level of social and physical vulnerability to human-induced disasters in disaster-prone communities of Lagos, Nigeria.

Design/methodology/approach
The study adopted the quantitative research method. Questionnaires were administered to household heads in three disaster-prone communities of Lagos, Nigeria. Using systematic random sampling technique, household heads’ opinions were sampled in 10 per cent of the buildings. This effort culminated in the sampling of 288 household heads in the three communities.

Findings
The study identified flood, fire outbreak and environmental pollution as the most prevalence disasters in the communities. State of infrastructure, housing conditions and residents’ socioeconomic characteristics were identified as the major factors influencing residents’ level of vulnerability to disasters in the communities.

Research limitations/implications
The study could be strengthened by looking at other disaster-prone communities in Nigeria with different cultural and political settings. Hence, the view presented in this paper may not be considered generalizable to other parts of the country with different cultural settings.

Originality/value
To build resilient communities in cities of developing countries, the paper of this nature is important to determine factors influencing residents’ level of vulnerability to disasters. This will aid in strengthening community-disaster preparedness in these countries.
Embracing conflicts for interpersonal competence development in project-based sustainability courses
Authors: Konrad Theres , Wiek Arnim , Barth Matthias 
Published: December 2019

PurposeAdvanced skills in communication, teamwork and stakeholder engagement are widely recognized as important success factors for advancing sustainability. While project-based learning formats claim to advance such skills, there is little empirical evidence that demonstrates how interpersonal competence is being developed. This study aims to describe and explains teaching and learning processes of project-based sustainability courses that contribute to the development of interpersonal competence as one of the key competencies in sustainability.Design/methodology/approachThis study on an international project-based learning course adopted a multi-method case study approach, triangulating observations, semi-structured interviews and focus groups supported by Photovoice method through which students tracked their learning processes. Data collection and analysis followed a grounded theory approach.FindingsLearning through and from conflicts within a learning community can foster competence development in teamwork, communication and stakeholder engagement. This study identified inner and outer conflicts (within individuals versus between individuals or groups) as potential drivers of learning processes, depending on strategies applied to address these conflicts.Originality valueThe value of this study is fourfold: it demonstrates how conflicts can be leveraged for students’ competence development; it provides in-depth empirical data from multiple perspectives, it discusses the findings in the context of teaching and learning theories, and it demonstrates an application of the Photovoice method to track and improve teaching and learning processes.
The influence of Islamic attributes and religious commitments toward halal wellness services customer satisfaction and loyalty
Authors: Sobari Nurdin , Kurniati Andyan , Usman Hardius 
Published: December 2019

Purpose
This study aims to analyze the behavior of Indonesian Muslim consumers toward halal wellness services, especially to determine the effect of Islamic attributes providing halal wellness services and customer religious commitment as a moderating variable on customer satisfaction and loyalty.

Design/methodology/approach
The study was carried out by surveying 260 respondents from 13 Muslim salon outlets in the Jabodetabek area as research samples. Furthermore, a quantitative approach with moderated regression analysis is used as an analytical tool to test the research hypothesis.

Findings
The study found that embedding Islamic attributes in a halal service correlated positively with customer satisfaction. Four of the six dimensions of Islamic attributes that provide halal wellness services have a significant influence on customer satisfaction and loyalty. In addition, it was found that the moderating effect of religious commitment variables was only significant on two Islamic attributes, namely, Muslim goods and services and halal labeled products.

Research limitations/implications
This study was conducted with samples taken from only one brand of muslimah salon in Jabodetabek area. So that generalization needs to be done with caution.

Practical implications
The paper includes implications for the marketing strategy of halal wellness services industry including the importance of experiential marketing strategy, the moderation between fiqh law compliance and customer convenience and the service customization based on customer preferences.

Originality/value
This paper gives an understanding of the behavior of halal wellness service users on how halal service attributes affect user satisfaction and loyalty.
Leadership lessons from the Titanic and Concordia disasters
Authors: Marko Matthew David , Gilman Lorene G. , Vasulingam Senthilkumar , Miliskievic Matthew , Spell Chester S. 
Published: December 2019

Purpose
This paper aims to investigate two famous disasters at sea, the Titanic and the Concordia, separated by 100 years, based on a comparison and analysis of those historical events, demonstrating how lessons learned and training methods used in the hazardous marine environments of aircraft carrier operations, as well as the near-solo conditions of technical scuba diving, can be better implemented in managing a large ship at sea.

Design/methodology/approach
This study starts with a historical analysis of these two ship-wrecks, both large, technically advanced ships that sank due to poor leadership, a breakdown in command and panic. Next, the study compares and contrasts scuba with operations aboard an aircraft carrier, two different maritime scenarios, yet similar in that there are many hazards that may require split-second decisions with limited or no communication with others. Both these mind-sets and training approaches have direct application to leadership and disaster planning on a large ship by being focused on minimizing decisions under stress in order to reduce panic.

Findings
This study demonstrates the value and impact of training that minimizes decisions under stress and enable people to make decisions independently in the face of a loss of communications. Focusing on two famous naval accidents, our analysis shows how such training can prevent panic and disaster, and can have direct application to leadership and disaster planning on a large ship.

Originality/value
This study uniquely compares and contrasts many of the planning and decision-making strategies used for both aircraft carrier operations and technical scuba diving, and the need to be able to make split-second decisions without communicating to others, and how these approaches can be used to better train a commercial ship to respond to an unforeseen disaster at sea.
Human resource management in merger and acquisition planning
Authors: Rodríguez-Sánchez José-Luis , Mora-Valentín Eva-María , Ortiz-de-Urbina-Criado Marta 
Published: December 2019

PurposeMany of the papers that analyse human resource management (HRM) in merger and acquisition (M&A) processes focus on the last two stages (integration and implementation). Then, the purpose of this paper is to propose an HRM model for the first stage of the process (planning) with four key factors: the due diligence process, the integration plan, the communication plan and the learning plan.Design/methodology/approachFrom the theoretical model, the authors analyse a case study of a multinational company that operates in the mechanical engineering sector.FindingsThe results show the special importance of HRM in the success of the M&A process. And, the main actions implemented in human resources (HRs) contributing to the success of this process are identified.Research limitations/implicationsSubsequent investigations could conduct similar analyses for the rest of the stages of the M&A process (integration and implementation), with the objective of presenting a complete HRM model in M&A processes.Practical implicationsThe case study allows researchers to learn from professionals and business leaders while also offering a theoretical model that can help managers make decisions and improve the management of these processes.Originality/valueThe main contribution of this study has been to observe how HRs are managed in the planning stage of M&As.
Do motives matter? Examining the relationships between motives, SSCM practices and TBL performance
Authors: Kitsis Aleksandr M. , Chen Injazz J. 
Published: December 2019

PurposeDrawing on multi-theoretical lenses and a combination of supply chain and business ethics literature, this study aims to investigate the role of motives in driving sustainable supply chain management (SSCM) practices and sustainable performance.Design/methodology/approachUsing a sample of 205 supply chain companies in the USA, the authors apply structural equation modeling (SEM) analysis to empirically test the proposed model and seven hypothesized relationships.FindingsResults of the study underscore the critical role of moral motives, while highlighting that all three types of motives (instrumental, relational and moral) are robust in driving SSCM practices and achieving improvement in all three dimensions of sustainable performance–economic, environmental and social.Research limitations/implicationsThis research can help supply chain scholars develop a more robust subfield of motivation-based SSCM research to gain a deeper understanding of how motives may differentially predict sustainable supply chain practices and performance.Practical implicationsThe results of this study demonstrate the critical links between moral motivation and the triple bottom line (TBL) performance and suggest that managers pay more attention to moral motives in their decision-making.Originality/valueThis study bridges gaps in the extant literature by incorporating motivation-based antecedents, expanding the scope of SSCM practices, including the social dimension of sustainability and investigating the mediating effects of SSCM practices on the links between motives and the TBL performance.
Managing cyber risk in supply chains: a review and research agenda
Authors: Ghadge Abhijeet , Weiß Maximilian , Caldwell Nigel D. , Wilding Richard 
Published: December 2019

Purpose
In spite of growing research interest in cyber security, inter-firm based cyber risk studies are rare. Therefore, this study aims to investigate cyber risk management in supply chain contexts.

Design/methodology/approach
Adapting a systematic literature review process, papers from interdisciplinary areas published between 1990 and 2017 were selected. Different typologies, developed for conducting descriptive and thematic analysis, were established using data mining techniques to conduct a comprehensive, replicable and transparent review.

Findings
The review identifies multiple future research directions for cyber security/resilience in supply chains. A conceptual model is developed, which indicates a strong link between information technology, organisational and supply chain security systems. The human/behavioural elements within cyber security risk are found to be critical; however, behavioural risks have attracted less attention because of a perceived bias towards technical (data, application and network) risks. There is a need for raising risk awareness, standardised policies, collaborative strategies and empirical models for creating supply chain cyber-resilience.

Research limitations/implications
Different types of cyber risks and their points of penetration, propagation levels, consequences and mitigation measures are identified. The conceptual model developed in this study drives an agenda for future research on supply chain cyber security/resilience.

Practical implications
A multi-perspective, systematic study provides a holistic guide for practitioners in understanding cyber-physical systems. The cyber risk challenges and the mitigation strategies identified support supply chain managers in making informed decisions.

Originality/value
To the best of the authors’ knowledge, this is the first systematic literature review on managing cyber risks in supply chains. The review defines supply chain cyber risk and develops a conceptual model for supply chain cyber security systems and an agenda for future studies.
Securing Urban Frontiers: A View from Yangon, Myanmar
Authors: Sarma Jasnea , Sidaway James D. 
Published: December 2019

AbstractThis article examines how variegated local and transnational interactions are reconfiguring Myanmar's largest city of Yangon. We do this through an analytical focus on frontiers and an empirical focus on how these are secured, drawing on interviews at two Security Expos and street‐level observations in Yangon conducted over three years. Yangon thereby becomes a site for critical reflections about complex and multiple imbrications of frontiers, security and the urban with implications for how these may be conceptualized elsewhere.
Differential frontal alpha oscillations and mechanisms underlying loss of consciousness: a comparison between slow and fast propofol infusion rates
Authors: Sepúlveda P. , Cortinez L. I. , Irani M. , Egaña J. I. , Contreras V. , Sánchez Corzo A. , Acosta I. , Sitaram R. 
Published: December 2019

SummaryMechanisms underlying loss of consciousness following propofol administration remain incompletely understood. The objective of this study was to compare frontal lobe electroencephalography activity and brainstem reflexes during intravenous induction of general anaesthesia, in patients receiving a typical bolus dose (fast infusion) of propofol compared with a slower infusion rate. We sought to determine whether brainstem suppression (‘bottom‐up’) predominates over loss of cortical function (‘top‐down’). Sixteen ASA physical status‐1 patients were randomly assigned to either a fast or slow propofol infusion group. Loss of consciousness and brainstem reflexes were assessed every 30 s by a neurologist blinded to treatment allocation. We performed a multitaper spectral analysis of all electroencephalography data obtained from each participant. Brainstem reflexes were present in all eight patients in the slow infusion group, while being absent in all patients in the fast infusion group, at the moment of loss of consciousness (p = 0.010). An increase in alpha band power was observed before loss of consciousness only in participants allocated to the slow infusion group. Alpha band power emerged several minutes after the loss of consciousness in participants allocated to the fast infusion group. Our results show a predominance of ‘bottom‐up’ mechanisms during fast infusion rates and ‘top‐down’ mechanisms during slow infusion rates. The underlying mechanisms by which propofol induces loss of consciousness are potentially influenced by the speed of infusion.
Sutureless intrascleral fixation using different three‐piece posterior chamber intraocular lenses: a literature review of surgical techniques in cases of insufficient capsular support and a retrospective multicentre study
Authors: Czajka Marcin Piotr , Frajdenberg Agata , Stopa Marcin , Pabin Tomasz , Johansson Björn , Jakobsson Gunnar 
Published: December 2019

AbstractWe present a literature review of surgical techniques of intraocular lens placement in eyes with insufficient capsular support, focusing on the most recent publications, together with a retrospective multicentre consecutive case series analysis of 103 eyes undergoing pars plana vitrectomy and sutureless intrascleral (SIS) fixation of a standard three‐piece PCIOL. Many different approaches appear in the literature without any specific procedure achieving superior outcomes. Advantages and disadvantages vary between techniques. Common complications related to IOL fixation techniques were as follow: anterior chamber IOL: transient/permanent corneal oedema (9–66.6%), uveitis (1.1–39.3%); iris‐fixated IOL: pupil ovalization (16–47.7%); and sutured scleral‐fixated IOL: suture breakage/exposure (6.1–11%), vitreous haemorrhage: (5.5–16.6%). In our retrospective case series, indications for surgery were postoperative aphakia in 50 eyes (49%), IOL dislocation in 38 eyes (37%) and natural lens dislocation in 15 eyes (14%). Scleral tunnels for haptic fixation were created with (28 eyes, 27.2%) or without (75 eyes, 72.8%) 25 gauge trocar cannulas. Complications included transient hypotony (n = 20; 19.4%), corneal decompensation (n = 7; 6.7%), IOL dislocation (n = 6; 5.8%), cystoid macular oedema (n = 5; 4.8%), vitreous haemorrhage (n = 4; 3.8%) and retinal detachment (n = 4; 3.8%). Mean best corrected visual acuity improved from logMAR 0.65 to 0.36 at the final visit (p = 0.001). In conclusion, SIS fixation provides good anatomical and functional outcomes; however, complications can occur. The number of surgical approaches for IOL dislocation described in the literature indicates that optimal treatment remains to be found.
Modeling pediatric medulloblastoma
Authors: Roussel Martine F. , Stripay Jennifer L. 
Published: December 2019

AbstractMouse models of medulloblastoma have proven to be instrumental in understanding disease mechanisms, particularly the role of epigenetic and molecular drivers, and establishing appropriate preclinical pipelines. To date, our research community has developed murine models for all four groups of medulloblastoma, each of which will be critical for the identification and development of new therapeutic approaches. Approaches to modeling medulloblastoma range from genetic engineering with CRISPR/Cas9 or in utero electroporation, to orthotopic and patient‐derived orthotopic xenograft systems. Each approach or model presents unique advantages that have ultimately contributed to an appreciation of medulloblastoma heterogeneity and the clinical obstacles that exist for this patient population.
Development and Validation of a Risk Prediction Model of Vancomycin‐Associated Nephrotoxicity in Elderly Patients: A Pilot Study
Authors: Pan Chen , Wen Aiping , Li Xingang , Li Dandan , Zhang Yang , Liao Yin , Ren Yue , Shen Su 
Published: December 2019

This exploratory study aimed to develop a risk prediction model of vancomycin‐associated nephrotoxicity (VANT) in elderly patients. Clinical information of elderly patients who received vancomycin therapy from January 2016 to June 2018 was retrieved. A total of 255 patients were included in this study. Univariate analysis and multivariable logistic regression analysis revealed that vancomycin trough concentration ≥ 20 mg/L (odds ratio (OR) = 3.009; 95% confidence interval (CI) 1.345–6.732), surgery (OR = 3.357; 95% CI 1.309–8.605), the Charlson Comorbidities Index ≥ 4 points (OR = 2.604; 95% CI 1.172–5.787), concomitant use of cardiotonic drug (OR = 3.283; 95% CI 1.340–8.042), plasma volume expander (OR = 3.459; 95% CI 1.428–8.382), and piperacillin/tazobactam (OR = 2.547; 95% CI 1.680–6.007) were risk factors for VANT in elderly patients. Furthermore, a VANT risk prediction model was developed, which had good discriminative power and was well‐calibrated.
Use of the Dyskinesia Impairment Scale in non‐ambulatory dyskinetic cerebral palsy
Authors: Haberfehlner Helga , Bonouvrié Laura A , Boeschoten Karin , Fleuren Sabine , Monbaliu Elegast , Becher Jules G , Vermeulen R Jeroen , Buizer Annemieke I 
Published: December 2019

AimTo assess the responsiveness, concurrent validity, and feasibility of the Dyskinesia Impairment Scale (DIS) in non‐ambulatory patients with dyskinetic cerebral palsy (CP).MethodThe study is a secondary analysis of data collected in the IDYS trial, a randomized controlled trial on the effects of intrathecal baclofen (ITB). The DIS and Barry–Albright Dystonia Scale (BADS) were conducted at baseline and after 3 months of ITB or placebo treatment. Responsiveness was assessed by comparing the effect sizes and correlation of change after treatment between the DIS and BADS. Concurrent validity was evaluated by assessing the correlations between scales. Feasibility was evaluated for each DIS item by the number of participants who successfully accomplished the item.ResultsThirty‐three non‐ambulatory patients (9 females, 24 males) with dyskinetic CP (ITB‐treated: n=17, mean [SD] age: 14y 1mo [4y 1mo]; placebo‐treated: n=16, mean [SD] age: 14y 7mo [4y]) were included in the study. The effect sizes for BADS and DIS were similar in The ITB‐treated group (−0.29 and −0.22 respectively). Changes after treatment on the DIS dystonia subscale correlated with changes on the BADS (r=0.64; p<0.001). The DIS dystonia subscale and BADS correlated at baseline and follow‐up (r=0.78; p<0.001 and r=0.79; p<0.001). Not all DIS activity items could be performed in this sample of patients.InterpretationFor non‐ambulatory patients with dyskinetic CP, the responsiveness of the DIS equalled the responsiveness of BADS. Concurrent validity was adequate. Feasibility for activity items was restricted in patients with severe dyskinetic CP.What this paper adds

The Dyskinesia Impairment Scale (DIS) and Barry–Albright Dystonia Scale showed similar responsiveness in non‐ambulatory patients with dyskinetic cerebral palsy (CP).

No floor or ceiling effect was observed for DIS in non‐ambulatory participants.

The concurrent validity of DIS was adequate in non‐ambulatory participants.

Patients with dyskinetic CP in Gross Motor Function Classification System levels IV and V could not perform all DIS activity items.