bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of knowledge, attitudes, and screening practices about cancer risk factors among health care professionals
Authors: Sheikhalipour Zahra , Ghahramanian Akram , Sanaat Zohreh , Vahedi Leila 
Published: April 2020

Abstract
Background: Given the importance of health care personnel’s awareness of cancer symptoms, this study aimed to investigate their knowledge regarding cancer warning symptoms, attitudes toward cancer risk factors, and performance on undertaking cancer screening tests.Methods: This was a cross-sectional study which 145 health care staff working in the medical centers affiliated with Tabriz University of Medical Sciences prticipated in it. The study population included nurses, midwives, operating room technicians, laboratory staff, anesthesiologists and radiologists. Items assessing awareness of cancer warning signs, risk factors, incidence, screening programmes were extracted from the literature.Results: The mean knowledge score of health care staffs was 7.97±2.01. Regarding the staff’s attitude toward the role of risk factors in increasing the likelihood of cancer, the results showed an average attitude score of 35.41±4.69. Concerning the performance of the participants in cancer screening tests, the results showed that out of 125 women aged 25-57 years, only 44% performed monthly self-examinations, 22.1% referred to a specialist physician for breast cancer screening every three years and only 20.51% of the female participants aged over 40 years old performed mammography. In terms of cervical cancer screening in female participants, 27.2% had performed annual Pap smear tests, and 17.6% referred to a specialist for annual pelvic examinations. Regarding colorectal cancer screening in staff older than 45 years, our findings showed that from 24 participants (16.6% of the samples), only one had undertaken occult blood test and performed colonoscopy.Conclusions: Because the public health depends on the wellness of health care professionals and their awareness of cancer warning signs, as well as their knowledge of cancer risk factors and adherence to cancer screening tests, they should be encouraged to perform these examinations.
Anticancer Activity of Lectins from Bauhinia purpurea and Wisteria floribunda on Breast Cancer MCF-7 Cell Lines
Authors: Agrawal Sanskruthi B. , Gupta Neha , Bhagyawant Sameer S. , Gaikwad Sushama M. 
Published: April 2020

Background:
Individual and collaborative efforts are being made worldwide in search
of effective chemical or natural drugs with less severe side-effects for treatment of cancer. Due to
the specificity and selectivity properties of lectins for saccharides, several plant lectins are known
to induce cytotoxicity into tumor cells.

Objective:
To study the antiproliferative activity of two N-acetyl galactosamine specific plant
lectins from seeds of Bauhinia purpurea and Wisteria floribunda against MCF-7 Breast cancer cell
lines.

Methods:
MTT, lactate dehydrogenase (LDH) leakage, reactive oxygen species (ROS), and caspase-
3 assays and flow cytometry for cell cycle analysis were performed.

Results:
The agglutinins BPL and WFL; 446 μgml-1 (2.2 μM) and 329 μgml-1 (2.8 μM), respectively
caused remarkable concentration-dependent antiproliferative effect on MCF-7. The effect was
seen to be a consequence of binding of the lectin to the cell surface and triggering S and G2 phase
arrest. Apoptosis induced was found to be associated with LDH leakage, cell cycle arrest and ROS
generation. The apoptotic signal was observed to be amplified by activation of caspase-3 resulting
in cell death.

Conclusion:
The study provides a base for detailed investigation and further use of lectins in cancer
studies.
Clinical Review: Safety and Efficacy Comparison between Sulfonylureas and Dipeptidyl Peptidase-4 Inhibitors as Second-Line Therapies in Type 2 Diabetes Mellitus
Authors: Gillani Syed Wasif , Moosvi Arzu F. 
Published: April 2020

Background:
According to the World Health Organization (WHO), diabetes mellitus is considered the
7th leading cause of death as of 2016, while almost half of all deaths related to high blood glucose occur before
the age of 70. According to the 2019 American Diabetes Association’s (ADA) guidelines, metformin is the firstline
treatment for patients with Type 2 diabetes. Additional therapy is dependent on multiple patient-specific
factors, including cardiovascular risks, risk of hypoglycemia, metabolic changes, and cost. The objective of this
systematic review is to analyze variables of interest in Type 2 diabetes including fasting blood glucose (FBG),
post-prandial blood glucose (PPBG), hemoglobin A1c (HbA1c), microvascular complications, and cardiovascular
outcomes in order to determine the shift towards the newer class of medications for type 2 diabetes.

Methods:
A systematic review was conducted using ScienceDirect as the primary source of obtaining articles.
This review used PRISMA for reporting and GRACE for quality assessment of ten articles. The inclusion criteria
for the review consisted of patients who were on metformin therapy for a sufficient amount of time, as defined by
the trial’s protocol, and who were then initiated on either a sulfonylurea (glipizide or glimepiride) or a DPP-4
inhibitor (saxagliptin or linagliptin). The articles included in this review range from 2005-2019 that are written in
English only. Exclusion criteria for this systematic review were articles in which patients were not initially started
on metformin therapy, were diagnosed with Type 1 diabetes mellitus, and articles that were written in languages
other than English.

Results:
After filtering 50 studies, 10 were selected for meeting the criteria of variables of interest. Findings
suggested a significant reduction in fasting plasma glucose with 154 mg/dL + 4 mg/dL as baseline, decreasing to
132 mg/dL + 4 mg/dL with the use of glipizide & metformin combination. A similar pattern was presented with
the use of saxagliptin and metformin in combination, but changes were less significant than glipizide. However,
hypoglycemic events in patients who were taking glipizide with metformin versus saxagliptin with metformin;
13.4% of patients achieved HbA1c <7% without hypoglycemic events compared to 22.2% of the patients who
achieved an HbA1c of <7% without hypoglycemic events.

Conclusion:
Despite the higher efficacious characteristics of sulfonylureas in lowering HbA1c, due to its reported
hypoglycemic effects, DPP-4 inhibitors may be considered as a clinically stable choice for second-line therapy
after completing maximally tolerated doses of metformin. Sulfonylureas are considered better than DPP-4 inhibitors
for treatment in patients with cardiovascular disease history and hypoglycemia.
Amano Lipase PS from Burkholderia cepacia- Evaluation of the Effect of Substrates and Reaction Media on the Catalytic Activity
Authors: Dulęba Jacek , Siódmiak Tomasz , Marszałł Michał Piotr 
Published: April 2020

:
Lipases in the native or immobilized form have commonly been used as catalysts
in the chemical and pharmaceutical industry. One of the widely available enzyme
catalysts on the market is lipase from Burkholderia cepacia (BCLs), previously called
Pseudomonas cepacia (PCLs). This enzyme is applied, among others, in the stereoselective
acylation of molecules to achieve chiral pure enantiomers of drugs or their building
blocks. In this study, Amano lipase PS (APS-BCL), which is a commercial lipase from
Burkholderia cepacia (BC) was tested. The lipolytic activity of APS-BCL by hydrolysis
of vegetable oils and enantioselective activity of APS-BCL by the kinetic resolution of
(R,S)-1-phenylethanol with using isopropenyl acetate as an acyl donor were evaluated. An
effect of reaction media with different logP values (t-butyl methyl ether, dichloromethane,
diisopropyl ether, toluene, cyclohexane, n-hexane, isooctane and n-heptane) on the enantioselective activity of
lipase was also studied. The high value of the enantiomeric ratio (E =308.5) with the utilization of isopropenyl
acetate was achieved. Whereas, the best reaction medium turned out to be diisopropyl ether, C =47.9%, eep
=98%, ees =90%, after 24 h of incubation. Moreover, the influence of ω6/ω9 polyunsaturated fatty acids (PUFAs)
ratio in commercial (peanut, camelina, rape, pumpkin seed, walnut, sesame, avocado, rice, corn, black
cumin, hemp, safflower, grape seed) oils was investigated for the lipase activity. For the first time, the cut-off
limit of ω6/ω9 ratio was proposed. The ratio equal to or higher than 2.3 allows achieving higher lipolytic activity.
Feasibility of a Home-Based Tablet App for Dexterity Training in Multiple Sclerosis: Usability Study
Authors: van Beek Judith Jantine Willemijn , van Wegen Erwin Everardus Henri , Rietberg Marc Berend , Nyffeler Thomas , Bohlhalter Stephan , Kamm Christian Philipp , Nef Tobias , Vanbellingen Tim 
Published: April 2020

Background
Persons with multiple sclerosis (MS) often experience dexterous difficulties during the performance of activities of daily living, such as fastening buttons, handling coins, or writing, therefore impacting their health-related quality of life. Mobile health (mHealth) solutions, such as tablet apps, may be used to train impaired dexterous skills. The feasibility of a tablet app–based dexterity home-based intervention in MS (TAD-MS) has not been explored yet in persons with MS.

Objective
The aim of this pilot study was to evaluate the feasibility and usability of home-based dexterity training with a tablet app in both persons with MS and healthy subjects.

Methods
A total of 9 persons with MS, aged 35-71 years, with an Expanded Disability Status Scale score between 2 and 7.5, performed the TAD-MS for 4 weeks, five times a week, with each training session lasting approximately 30 minutes. Participants’ impaired dexterity was measured by the Nine-Hole Peg Test. A total of 10 age-matched healthy subjects also tested and rated the usability of the app. Outcome measures were the adherence rate as well as usability measured by the System Usability Scale and a Custom User Engagement Questionnaire (CUEQ).

Results
High feasibility of the tablet app–based dexterity training program was shown by a 97% adherence rate to the training protocol (ie, mean 19.4/20 sessions completed, SD 0.8). High system usability scores (ie, mean 85.39%, SD 11.67) and overall high scores given in the CUEQ (ie, mean 8.2/10, SD 1.4) further point to high usability of the app. Neither demographic variables nor dexterity levels affected the use of the app.

Conclusions
This pilot study is the first to demonstrate high feasibility and usability of a new tablet app–based dexterity home-based training program among both persons with MS and healthy individuals. Whether this kind of training improves dexterity will need to be evaluated in a randomized controlled trial.
Identifikasi Sanitasi Rumah Sehat dengan Metode Multifactor Evaluation Process
Authors: Aldo Dasril 
Published: April 2020

Penelitian ini bertujuan untuk memudahkan pihak Pusat Kesehatan Masyarakat dalam mengidentifikasi sanitasi rumah sehat. Sebagai pendukung dalam penelitian ini, akan menggunakan metode Multifactor Evaluation Process untuk melakukan analisis terhadap 20 data sanitasi yang didapatkan dari Pusat Kesehatan Masyarakat Seberang Padang dengan kriteria penilaian berupa Komponen Rumah, Sarana Sanitasi dan Prilaku Penghuni. Tahapan dari metode ini yaitu menetapkan bobot evaluasi masing-masing kriteria, menentukan nilai evaluasi faktor dan menghitung nilai total evaluasi sebagai nilai akhir dalam pengambilan keputusan. Dari pengujian terhadap 20 data sanitasi mendapatkan hasil berupa rumah tidak sehat 70% dan rumah sehat 30% dengan kecocokan 95% terhadap hasil yang didapatkan oleh pihak Pusat Kesehatan Masyarakat Seberang Padang. Dengan kecocokan tersebut maka metode ini cocok digunakan dalam identifikasi sanitasi rumah sehat. Kata Kunci: Identifikasi, Multifactor Evaluation Process, Sanitasi Rumah Sehat
Perancangan Sistem Informasi Penerimaan Negara Bukan Pajak Pada Kantor Kesehatan Pelabuhan Jambi
Authors: Aryani Lies 
Published: April 2020

Di era globalisasi, Sistem Informasi telah digunakan oleh banyak pihak, mulai dari tingkat organisasi, lembaga pendidikan hingga instansi baik swasta ataupun pemerintahan. Sistem Informasi memberikan pengaruh signifikan untuk membantu pihak manajemen dalam mengabil keputusan dan pembuatan laporan.Kantor Kesehatan Pelabuhan Jambi salah satu instansi pemerintahan yang memiliki sadar tentang informasi dan teknologi. Namun layanan administrasi penerimaan negara bukan pajak bagi pengunjung masih menggunakan sistem konvensional. Oleh karena itu, kegiatan administrasi yang lambat dan pengunjung masih kurang efektif. Masih ada kesalahan dalam memproses informasi dan laporan yang tidak tepat waktu.Diharapkan Sistem Informasi yang akan dirancang ini dapat mengoptimalkan kebutuhan Informasi di Kantor Kesehatan Pelabuhan Jambi. Aplikasi yang didasarkan dari Visual basi.Net. ini bertujuan untuk mengelola waktu secara efisien, membuat data diproses secara akurat, dan efisien dalam laporan.
El regreso de la diosa Fortuna en la «sociedad del riesgo»
Authors: González García José M. 
Published: April 2020

ResumenEl artículo presenta una de las versiones de la teoría sociológica del riesgo, en la tradición de estudios sobre la diosa Fortuna. En concreto, la desarrollada por Ulrich Beck. Desde esta posición, analiza la interpretación que beck hace de la modernidad en los términos de «modernidad reflexiva» y extrae las consecuencias que se derivan para una concepción moderna y reflexiva de lo políticoPALABRAS CLAVEMODERNIDAD-POLITICA-RIESGO-BECK-FORTUNAABSTRACTThe paper deals with one of the versions of the sociological theory of risk, within the tradition of studies on the goddess Fortune. Namely, the one developed by Ulrich Beck. From this position, it examines Beck's interpretation of modernity in terms of «reflexive modernity» and draw its consequences for a modern, reflexive conception of the political KEYWORDSMODERNITY- POLITICS-RISK-BECK-FORTUNE
Nilai Total Flavonoid dalam Black garlic (Allium sativum L.) berdasarkan fraksi pelarut dan Aktivitas Antioksidannya
Authors: Wardhani Gladys Ayu Paramita Kusumah , Azizah Mia , Hastuti Lisnawati Tri 
Published: April 2020

Black garlic adalah produk bawang putih yang telah diproses melalui reaksi pencoklatan non enzimatis (Reaksi Maillard) pada suhu tertentu dalam waktu lama, sehingga menghasilkan senyawa baru yang mempunyai efek farmakologis, salah satunya sebagai antioksidan. Flavonoid merupakan kelompok senyawa fenolik terbesar yang terdapat pada tanaman, diketahui dapat menangkal stres oksidatif di tubuh manusia. Penelitian ini bertujuan untuk menentukan kandungan total flavonoid dari fraksi black garlic (Allium Sativum L.) serta menentukan aktivitas antioksidannya pada fraksi yang memiliki nilai total flavonoid tertinggi. Tahap pertama adalah perolehan total ekstrak metanol, selanjutnya ekstraksi fraksinasi menggunakan air, diklorometana dan n-heksana. Tahap kedua adalah uji kualitatif senyawa flavonoid dengan metode Wilstatter. Tahap ketiga adalah analisis total flavonoid dengan metode standar eksternal menggunakan instrumen Spektrofotometer UV-Vis. Tahap terakhir adalah uji aktivitas antioksidan dengan standar Kuersetin. Hasil yang diperoleh yaitu ekstrak black garlic dalam air, diklorometana, dan n-heksana positif mengandung flavonoid. Ekstrak diklorometana memiliki nilai total flavonoid paling besar yaitu 55,68 mg QE/g ekstrak, diikuti oleh nilai total flavonoid ekstrak air dan ekstrak n-heksana masing-masing sebesar 10,31 dan 5,11 mg QE/g ekstrak. Nilai IC50 black garlic dalam ekstrak diklorometana sebesar 361,07 µg/mL sehingga digolongkan sebagai senyawa dengan tingkat antioksidan yang sedang. Kata Kunci: black garlic, flavonoid, antioksidan, diklorometana
Analisis Kelayakan Usaha Produksi Tahu Sumedang (Studi Kasus Di Pabrik Tahu XY Kecamatan Conggeang)
Authors: Sa'id Nur Ali , Ma'ruf Amar , Delfitriani Delfitriani 
Published: April 2020

Feasibility analysis of XY tofu production business is a factory that produces traditional food typical of the Sumedang district. This production utilizes the marketing sector and marketing location which is located near the sub-district traditional market. This study aims to analyze the business of tofu Sumedang in the XY tofu factory which includes non-financial aspects (Market aspects, marketing, engineering, management, legal, social and environmental), and financial aspects. Based on non-financial results hat the non-financial aspects affect the operation of the tofu XY production business. Based on the results of the calculation of financial aspects it is feasible to carry out the NVP value generated for 10 years Rp. 579,177,261 -, with production capacity per month producing tofu 216.000 seed and 6.806 kg tofu dregs per month. The IRR obtained is 0,41% where the IRR is more than 0%. Net B / C obtained is 2,92, this means, every Rp. 1 spent on running this business will generate net benefits of Rp.2,92. The payback period obtained is 2,63 years. The sensitivity analysis for this project shown an increase in operational / production costs of 10%, an increase in raw materials and additional materials by 20% and a decrease in selling prices by 10% which does not affect this business.Keywords: feasibility business, financial analysis, sensitivity analysis
Stereotactic radiosurgery for central neurocytomas: an international multicenter retrospective cohort study
Authors: Hung Yi-Chieh , Lee Cheng-Chia , Yang Huai-che , Mohammed Nasser , Kearns Kathryn N. , Sun Shi-Bin , Mathieu David , Touchette Charles J. , Atik Ahmet F. , Grills Inga S. , Squires Bryan , Ding Dale , Williams Brian J. , Yusuf Mehran B. , Woo Shiao Y. , Liscak Roman , Hanuska Jaromir , Shiao Jay C. , Kondziolka Douglas , Lunsford L. Dade , Xu Zhiyuan , Sheehan Jason P. 
Published: April 2020

OBJECTIVE
Central neurocytomas (CNs) are uncommon intraventricular tumors, and their rarity renders the risk-to-benefit profile of stereotactic radiosurgery (SRS) unknown. The aim of this multicenter, retrospective cohort study was to evaluate the outcomes of SRS for CNs and identify predictive factors.

METHODS
The authors retrospectively analyzed a cohort of patients with CNs treated with SRS at 10 centers between 1994 and 2018. Tumor recurrences were classified as local or distant. Adverse radiation effects (AREs) and the need for a CSF shunt were also evaluated.

RESULTS
The study cohort comprised 60 patients (median age 30 years), 92% of whom had undergone prior resection or biopsy and 8% received their diagnosis based on imaging alone. The median tumor volume and margin dose were 5.9 cm3 and 13 Gy, respectively. After a median clinical follow-up of 61 months, post-SRS tumor recurrence occurred in 8 patients (13%). The 5- and 10-year local tumor control rates were 93% and 87%, respectively. The 5- and 10-year progression-free survival rates were 89% and 80%, respectively. AREs were observed in 4 patients (7%), but only 1 was symptomatic (2%). Two patients underwent post-SRS tumor resection (3%). Prior radiotherapy was a predictor of distant tumor recurrence (p = 0.044). Larger tumor volume was associated with pre-SRS shunt surgery (p = 0.022).

CONCLUSIONS
Treatment of appropriately selected CNs with SRS achieves good tumor control rates with a reasonable complication profile. Distant tumor recurrence and dissemination were observed in a small proportion of patients, which underscores the importance of close post-SRS surveillance of CN patients. Patients with larger CNs are more likely to require shunt surgery before SRS.
Quantifying eloquent locations for glioblastoma surgery using resection probability maps
Authors: Müller Domenique M. J. , Robe Pierre A. , Ardon Hilko , Barkhof Frederik , Bello Lorenzo , Berger Mitchel S. , Bouwknegt Wim , Van den Brink Wimar A. , Conti Nibali Marco , Eijgelaar Roelant S. , Furtner Julia , Han Seunggu J. , Hervey-Jumper Shawn L. , Idema Albert J. S. , Kiesel Barbara , Kloet Alfred , De Munck Jan C. , Rossi Marco , Sciortino Tommaso , Vandertop W. Peter , Visser Martin , Wagemakers Michiel , Widhalm Georg , Witte Marnix G. , Zwinderman Aeilko H. , De Witt Hamer Philip C. 
Published: April 2020

OBJECTIVE
Decisions in glioblastoma surgery are often guided by presumed eloquence of the tumor location. The authors introduce the “expected residual tumor volume” (eRV) and the “expected resectability index” (eRI) based on previous decisions aggregated in resection probability maps. The diagnostic accuracy of eRV and eRI to predict biopsy decisions, resectability, functional outcome, and survival was determined.

METHODS
Consecutive patients with first-time glioblastoma surgery in 2012–2013 were included from 12 hospitals. The eRV was calculated from the preoperative MR images of each patient using a resection probability map, and the eRI was derived from the tumor volume. As reference, Sawaya’s tumor location eloquence grades (EGs) were classified. Resectability was measured as observed extent of resection (EOR) and residual volume, and functional outcome as change in Karnofsky Performance Scale score. Receiver operating characteristic curves and multivariable logistic regression were applied.

RESULTS
Of 915 patients, 674 (74%) underwent a resection with a median EOR of 97%, functional improvement in 71 (8%), functional decline in 78 (9%), and median survival of 12.8 months. The eRI and eRV identified biopsies and EORs of at least 80%, 90%, or 98% better than EG. The eRV and eRI predicted observed residual volumes under 10, 5, and 1 ml better than EG. The eRV, eRI, and EG had low diagnostic accuracy for functional outcome changes. Higher eRV and lower eRI were strongly associated with shorter survival, independent of known prognostic factors.

CONCLUSIONS
The eRV and eRI predict biopsy decisions, resectability, and survival better than eloquence grading and may be useful preoperative indices to support surgical decisions.