bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regards croisés sur l’évolution de la pénurie d’eau de la ville de Zinder (Niger) de 1900 à nos jours
Authors: Malam Abdou Moussa , Saley Boubé Bali , Mamadou Ibrahim , Issaka Brah Laminou 
Published: June 2020

Depuis les années 1920, la ville de Zinder est confrontée à une pénurie récurrente d’eau de consommation dont les causes sont diversement interprétées selon les contextes et les périodes. Ce travail propose des regards croisés pour appréhender la profondeur du problème. À partir d’un inventaire de récits étiologiques analysés avec les outils de la mythocritique d’une part, des données hydrométriques et des enquêtes d’autre part, les questions relatives à la production et à la gestion de l’eau, au pessimisme des populations quant à une solution définitive sont étudiées. Les analyses croisées mettent en évidence trois principales explications. D’abord, l’imaginaire populaire enseigne que la pénurie d’eau trouve son explication dans des mythes qui, loin d’être de simples ornements culturels, s’inscrivent dans une perspective de légitimation d’un pouvoir face à des envahisseurs à la peau blanche. Ensuite, l’analyse de débits des forages met en exergue la faible disponibilité de la ressource du fait du soubassement cristallin très peu altéré. Ainsi, sur une quinzaine de forages échantillonnés autour de la ville, la productivité moyenne est de 0,57 m3∙h-1 (±0,47). Soixante pour cent des forages ont un débit inférieur à la moyenne et sont à peine considérés comme productifs. Enfin, les volumes d’eau produits par les stations de pompage sont toujours inférieurs aux besoins croissants des usagers. Les infrastructures hydrauliques réalisées et les arguments scientifiques fournis convainquent de moins en moins les populations quant à la résolution définitive de la pénurie d’eau. De ce fait, selon l’interlocuteur ou l’échelle spatiale d’analyse, la pénurie s’interprète comme une donnée naturelle, économique et sociopolitique. Pour gérer cette pénurie, les structures d’exploitation de l’eau de la ville ont développé des stratégies telles que le délestage, l’utilisation de « bons » d’accès à l’eau et la limitation des branchements.
Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
Authors: Tan Hui Yee , Tan Sik Loo , Teo Seow Hui , Roebuck Margaret M. , Frostick Simon P. , Kamarul Tunku 
Published: June 2020

BackgroundType 2 diabetes mellitus (T2DM) had been reported to be associated with tendinopathy. However, the underlying mechanisms of diabetic tendinopathy still remain largely to be discovered. The purpose of this study was to develop insulin resistance (IR) model on primary human tenocytes (hTeno) culture with tumour necrosis factor-alpha (TNF-α) treatment to study tenocytes homeostasis as an implication for diabetic tendinopathy.MethodshTenowere isolated from human hamstring tendon. Presence of insulin receptor beta (INSR-β) on normal tendon tissues and the hTeno monolayer culture were analyzed by immunofluorescence staining. The presence of Glucose Transporter Type 1 (GLUT1) and Glucose Transporter Type 4 (GLUT4) on the hTeno monolayer culture were also analyzed by immunofluorescence staining. Primary hTeno were treated with 0.008, 0.08, 0.8 and 8.0 µM of TNF-α, with and without insulin supplement. Outcome measures include 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucose (2-NBDG) assay to determine the glucose uptake activity; colourimetric total collagen assay to quantify the total collagen expression levels; COL-I ELISA assay to measure the COL-I expression levels and real-time qPCR to analyze the mRNA gene expressions levels of Scleraxis (SCX), Mohawk (MKX), type I collagen (COL1A1), type III collagen (COL3A1), matrix metalloproteinases (MMP)-9 and MMP-13 in hTeno when treated with TNF-α. Apoptosis assay for hTeno induced with TNF-α was conducted using Annexin-V FITC flow cytometry analysis.ResultsImmunofluorescence imaging showed the presence of INSR-β on the hTeno in the human Achilles tendon tissues and in the hTeno in monolayer culture. GLUT1 and GLUT4 were both positively expressed in the hTeno. TNF-α significantly reduced the insulin-mediated 2-NBDG uptake in all the tested concentrations, especially at 0.008 µM. Total collagen expression levels and COL-I expression levels in hTeno were also significantly reduced in hTeno treated with 0.008 µM of TNF-α. The SCX, MKX and COL1A1 mRNA expression levels were significantly downregulated in all TNF-α treated hTeno, whereas the COL3A1, MMP-9 and MMP-13 were significantly upregulated in the TNF–α treated cells. TNF-α progressively increased the apoptotic cells at 48 and 72 h.ConclusionAt0.008 µM of TNF-α, an IR condition was induced in hTeno, supported with the significant reduction in glucose uptake, as well as significantly reduced total collagen, specifically COL-I expression levels, downregulation of candidate tenogenic markers genes (SCX and MKX), and upregulation of ECM catabolic genes (MMP-9 and MMP-13). Development of novel IR model in hTeno provides an insight on how tendon homeostasis could be affected and can be used as a tool for further discovering the effects on downstream molecular pathways, as the implication for diabetic tendinopathy.
Synthesis, Characterization and Antibacterial Study of Co (II) and Cu (II) Complexes of Sulfamethoxazole
Authors: Adamu Usman Abubakar , Magaji Buhari , Mohammad Adamu Baba , Sani Mukhtar Muhammad , Adoram Nitte 
Published: June 2020

Complexes of Co and Cu with SMZ were successfully synthesized (1:2 molar ratio) in good yield and characterized by using UV-vis, FTIR, melting point/decomposition temperature, electrical conductivity and solubility in different solvents of varying polarity and proticity. All the prepared complexes were coloured. From the IR results, 529, 631, 528 and 779 cm-1 bands were observed in the spectra of the complexes which were absent in the free ligand spectrum thus, showing the presence of metal-ligand bond (coordination) in the complexes. The electronic spectral data of the complexes suggest an octahedral and tetrahedral geometry for all the complexes. The ligand and the Co (II) complex were found to be soluble polar protic solvents at both room and elevated temperature while, Cu (II) complex was found to be insoluble in polar protic solvent (ethanol) at room temperature but soluble at elevated temperature. The metal complexes are insoluble in non-polar solvent at both temperatures. More so, the ligand was found to be soluble in non-polar solvent at both temperatures. The electrical conductivity measurements indicated that the synthesized complexes are non-electrolytes. The synthesized metal complexes showed improved broad-spectrum antimicrobial activity against E. coli and S. aureus as compared to the ligand. Thus, the complexes [Co(C10H11N3O3S)] and [Cu(C10H11N3O3S)] are good leads to be developed into antibiotics against the tested antimicrobial agents (E. coli and S. aureus).
Nutrition Food Labeling in the Saudi Market between Compliance and Relaxing Policy
Authors: AlMughthem Amal , Jradi Hoda , Bawazir Amen 
Published: June 2020

Background: With increased demand for prepackaged food, the nutrient content of those products has increased especially fat, sugar, and sodium. We aimed to assess the compliance of nutritional labeling and to analyze the stated nutritional components as presented on prepackaged food products in Saudi market.
Methods: A total of 1153 foods were randomly sampled from fourteen stores. Nutritional information was taken from nutrient declarations present on food labels and assessed through a comparison of mean levels and assess compliance with Saudi Food and Drug Authority regulations.
Results: Overall, of the total number of products surveyed, 88% displayed nutritional facts, while 12% did not. Of the total products that had nutritional facts, only 38% met SFDA requirements while 97% disclosed the four key nutritional elements (energy, carbohydrate, protein and fat). In total, almost one third of the products had a high fat content, 40% were high in sugar and 20% were high in Sodium. We found also, 20% listed hydrogenated fat in their ingredient information, 90% of which was fully hydrogenated, while 10% was partially hydrogenated.
Conclusion: There was a high percentage of products that displayed nutritional facts, but only a small percentage complied with SFDA's recent regulations. Food reformulation could have an extraordinary potential to overcome the increase in nutrition-related chronic disease in Saudi Arabia, and the information acquired from this paper provides an overview of thinking about the food supply as a major source needed for a national intervention.
Evaluation of Rice Genotypes for Salinity Tolerance at Reproductive Stage Using Phenotypic and Molecular Markers
Authors: Kumar Anuj , Dwivedi D. K. , Bharti Pradeep K. , Singh Vineeta , Kumari Preeti , Khan N. A. 
Published: June 2020

Rice is the single largest source of food energy for more than half of the world’s population. Salinity may be a serious environmental constraint to crop production. Salinity screening of twenty rice genotypes were performed at the reproductive stages, in the net house of department of PMB&GE. Phenotyping of the genotypes was done at EC 12dS/m at reproductive stage in net house. Most desirable genotypes days to 50% flowering were IR-68144-2B-2-2-3-1-120, CSR-13, FL-478, NDR-359, AYYAR and NUD-2, SAMBHA MANSURI and MTU-1010; for plant height IR-68144-2B-2-2-3-1-127, NUD-3, NUD-2, NDRK-2008, IR-91171-66-3-2-1-3, SAMBHA MANSURI, TARAMON and MTU-1010; for panicle bearing tillers/plant FL-478, NDR-359 and SWARNA; for panicle length IR-68144-2B-2-2-3-1-127, IR-91167-99-1-1-1-3, IR-29, FL-478, NDRK-2008 and IR-92953-49-1-3; for spikelets/panicle IR-91167-99-1-1-1-3, NDRK-2008, SWARNA , IR-92953-49-1-3, IR-91171-66-3-2-1-3, IR-83668-35-2-2-2 and MTU-1010; for grains/panicle SWARNA, IR-92953-49-1-3, IR-91171-66-3-2-1-3, IR-83668-35-2-2-2, NDRK-2008 and MTU-1010 for spikelet fertility % NUD-3, IR-29, FL-478, NDRK-2008, SWARNA, IR-91171-66-3-2-1-3 and IR-83668-35-2-2-2; for test weight NUD-3, NDRK-2008, IR-29 and SWARNA for biological yield/plant AYYAR, TARAMON and NUD-3; for harvest index FL-478, IR-68144-2B-2-2-3-1-120, IR-91167-133-1-1-2-3 and NUD-2; for Na+ NUD-3 and FL-478; for K+ IR-91167-133-1-1-2-3, NDR-359 and MTU-1010; for Na+/K+ IR-68144-2B-2-2-3-1-127, IR-91167-99-1-1-1-3, NUD-3, FL-478, IR-64 and SAMBHA MANSURI; for grain yield/ plant (g) AYYAR and FL-478 were reported highly significant in mean performance for yield and its components traits. Analysis of variance, estimates of phenotypic and genotypic coefficient of variation, estimates of heritability and genetic advance in percent of mean were recorded for all the characters among 20 rice genotypes in saline condition. Molecular analysis with SSR markers differentiates the rice genotypes into tolerant and susceptible based on banding pattern. The tolerant rice genotypes were NUD 3, IR-68144-2B-2-2-3-166, IR68144-2B-2-2-3-1-120, IR68100-2B-2-2-3-1-127, IR-1167-31-3-1-33 and IR-91171-66-3-2-1-3 and susceptible were NDR-359, Taramon, MTU-1010, Swarna and IR-64. The identified salt tolerant genotypes can be potential germplasm sources for future breeding programmes.
Assessment of Overweight, Obesity and the Dietary Habits of Undergraduate Students of Lagos State University
Authors: Arisa N. , Anaemene D. , Mekwunye W. 
Published: June 2020

Aims: To determine the prevalence of overweight, obesity and dietary habits of under graduate students of Lagos State University.
Study Design: The study was a descriptive cross-sectional survey.
Place and Duration of Study: Lagos State University, Lagos, Nigeria, between June 2016 and July 2016.
Methodology: 150 undergraduate students were selected through multistage random sampling. Information on socio-demographic characteristics, dietary habit and physical activity was obtained using structured questionnaire. Weight, height, Percentage Body Fat (PBF), waist and hip circumferences were measured according to standard procedures to compute Body Mass Indices (BMI), Waist Hip Ratio (WHR) and finally determine nutritional status. The data were presented as frequencies, percentages, mean and standard deviations. Chi square was used to test for significant differences and level of significance set at 0.05.
Results: The mean BMI, PBF and WHR of the participants were 23.4 ± 2.3 kg/m2, 23.1 ± 5.0% and 0.83 ± 0.09, respectively. Majority of the participants (86.7%) were of normal weight while 8% (10.4% males and 5.5% females) and 5.3% (5.2% males and 5.5% females) were overweight and obese, respectively. Using WHR, more number of students were overweight/obese (34%) compared to BMI (13.3%) and PBF (8.7%), all indicated higher abnormal status among males than females. Few students exhibited poor eating (15%) and physical inactivity (16%) habits. Majority of the students (75.3%) skipped breakfast and the least daily consumed food group was legume/nut group (0.5%). Snacks (42%) and processed (20%) foods were consumed more than roots/tubers (14%) which are staple foods.
Conclusion: Central obesity was high among undergraduate students of Lagos State University. Breakfast skipping and low legume meal consumption were major dietary problems. Healthy lifestyle should be promoted among the university students to prevent overweight/obesity and its associated diseases.
The Isolation of Antimicrobial Resistant Aeromonas spp. from Aquaculture Samples and their Susceptibility to Medicinal Plant Extracts
Authors: Chikwendu C. I. , Obi R. K. , Ibe K. C. , Orji J. C. 
Published: June 2020

Aeromonas spp, ubiquitous in both terrestrial and aquatic environments are becoming renowned as enteric pathogens of serious public health concern as they have a number of virulence and resistant determinants that are linked to both human and aquatic diseases due to consistent and incorrect use of antibiotics in aquaculture. The effect of crude aqueous and ethanol extracts of some medicinal plants on antimicrobial resistant Aeromonas spp. isolated from aquaculture water and fish samples was studied. Two hundred and forty (240) Aeromonas isolates, made up of 168 Aeromonas hydrophila and 72 Aeromonas salmonicida, were recovered from aquaculture water and fish gill samples collected from different commercial fish ponds using selective media. The isolates were assessed for their antibiotic susceptibility against ten (10) conventional antibiotics using the Kirby-Bauer technique. Extracts from three medicinal plants, Vernonia amygdalina, Ocimum gratissimum and Garcinia kola were also analyzed for their antimicrobial effects on the isolates that were resistant to the conventional antibiotics. Aeromonas hydrophila isolates expressed the highest resistant rates of 100%, 78.6% and 70.8% to aztreonam, cefotaxime and neomysin respectively, and the A. salmonicida isolates also had a similar trend of high resistant rates of 100%, 87.5% and 77.8% to aztreonam, neomysin and cefotaxime respectively. Antimicrobial resistant analyses with the plant extracts showed 100% inhibition of the isolates at 100 mg/ml for both aqueous and ethanol extracts. Phytochemical screening identified the presence of certain phytochemicals like alkaloids, saponins, tannins, flavonoids, steroids and glycosides which could have accounted for the antimicrobial effects of the plant extracts under study. It can be inferred then, that extracts from Vernonia amygdalina, Ocimum gratissimum and Garcinia kola can inhibit resistant aquaculture Aeromonas isolates and so can present an alternative source of antimicrobials in the effort to combat the increasing incidence of antimicrobial resistance in aquaculture.
Prospektive Erfassung der postinterventionellen Lebensqualität nach Adenotomie und Adenotonsillotomie bei Kindern
Authors: Stupp F. , Grossi A. , Hoffmann T. K. , Sommer F. , Lindemann J. 
Published: June 2020

Zusammenfassung
Hintergrund
Die Bewertung der Effektivität der Adenotomie (AT) und Adenotonsillotomie (ATT) bei symptomatischer adenotonsillärer Hyperplasie orientiert sich in Studien oft nur am Ausmaß der postoperativen Symptomreduktion. Daher sollte erstmals im Rahmen dieser Studie erfasst werden, ob die AT und ATT zu einer postoperativen Verbesserung der kindlichen Lebensqualität (LQ) mittels dem Fragebogen „Glasgow Children’s Benefit Inventory“ (GCBI) und einer visuellen Analogskala (VAS) zur LQ führt.

Material und Methoden
Es wurden n = 111 Kinder prospektiv rekrutiert (3 bis 6 Jahre, ♂ 65 % ♀ 35 %, Æ Alter 4,2 Jahre, AT (66 %), ATT (34 %), Follow-up 3,5 Monate). Die kindliche LQ wurde mittels GCBI (24 Items) und einer VAS zur LQ (0 bis 10 Punkte) erfasst.

Ergebnisse
Bei 107 Kindern (96,4 %) ergab sich eine postoperative Verbesserung der LQ anhand der GCBI-Score-Werte. Es ergab sich ein mittlerer Score-Wert von +32,7 ± 22,14, Konfidenzintervall (KI) [+28,5–+36,9] mit maximal +97,9 und minimal −25,0 Punkten. In der Gruppe ATT wurde mit +39,4 ± 25,18 ein signifikant höherer mittlerer Score-Wert als in der Gruppe AT +29,3 ± 19,67 erreicht (p = 0,024). Bei 91 (82,0 %) der Kinder gaben die Eltern postoperativ einen höheren Punktewert in der VAS an, bei 16 (14,4 %) bemerkten die Eltern keine Änderung, nur bei 4 (3,6 %) verschlechterte sich die LQ.

Diskussion
Schon die reine Rachenmandelhyperplasie beeinflusst die allgemeine LQ relevant. Die Verbesserung der LQ in GCBI und VAS durch die Operation belegt den klaren Benefit. Bei zusätzlicher Hyperplasie der Gaumenmandeln verbessert eine zusätzliche Tonsillotomie die LQ noch deutlicher. Adenotomie und Adenotonsillotomie sind daher bei differenzierter Indikationsstellung effektive Operationen, um neben der reinen Symptomreduktion auch eine signifikante Verbesserung der kindlichen LQ zu erzielen.
The evolution of parental care strategies in subsocial wasps
Authors: Field Jeremy , Gonzalez-Voyer Alejandro , Boulton Rebecca A. 
Published: June 2020

Abstract
Insect parental care strategies are particularly diverse, and prolonged association between parents and offspring may be a key precursor to the evolution of complex social traits. Macroevolutionary patterns remain obscure, however, due to the few rigorous phylogenetic analyses. The subsocial sphecid wasps are a useful group in which to study parental care because of the diverse range of strategies they exhibit. These strategies range from placing a single prey item in a pre-existing cavity to mass provisioning a pre-built nest, through to complex progressive provisioning where a female feeds larvae in different nests simultaneously as they grow. We show that this diversity stems from multiple independent transitions between states. The strategies we focus on were previously thought of in terms of a stepping-stone model in which complexity increases during evolution, ending with progressive provisioning which is a likely precursor to eusociality. We find that evolution has not always followed this model: reverse transitions are common, and the ancestral state is the most flexible rather than the simplest strategy. Progressive provisioning has evolved several times independently, but transitions away from it appear rare. We discuss the possibility that ancestral plasticity has played a role in the evolution of extended parental care.

Significance statement
Parental care behaviour leads to prolonged associations between parents and offspring, which is thought to drive the evolution of social living. Despite the importance of insect parental care for shaping the evolution of sociality, relatively few studies have attempted to reconstruct how different strategies evolve in the insects. In this study, we use phylogenetic methods to reconstruct the evolution of the diverse parental care strategies exhibited by the subsocial digger wasps (Sphecidae). Contrary to expectations, we show that parental care in this group has not increased in complexity over evolutionary time. We find that the ancestral state is not the simplest, but may be the most flexible strategy. We suggest that this flexible ancestral strategy may have allowed rapid response to changing environmental conditions which might explain the diversity in parental care strategies that we see in the digger wasps today.
The Kaiser score reliably excludes malignancy in benign contrast-enhancing lesions classified as BI-RADS 4 on breast MRI high-risk screening exams
Authors: Milos Ruxandra Iulia , Pipan Francesca , Kalovidouri Anastasia , Clauser Paola , Kapetas Panagiotis , Bernathova Maria , Helbich Thomas H. , Baltzer Pascal A. T. 
Published: June 2020

Abstract
Objectives
MRI is an integral part of breast cancer screening in high-risk patients. We investigated whether the application of the Kaiser score, a clinical decision-support tool, may be used to exclude malignancy in contrast-enhancing lesions classified as BI-RADS 4 on breast MRI screening exams.

Methods
This retrospective study included 183 consecutive, histologically proven, suspicious (MR BI-RADS 4) lesions detected within our local high-risk screening program. All lesions were evaluated according to the Kaiser score for breast MRI by three readers blinded to the final histopathological diagnosis. The Kaiser score ranges from 1 (lowest, cancer very unlikely) to 11 (highest, cancer very likely) and reflects increasing probabilities of malignancy, with scores greater than 4 requiring biopsy. Receiver operating characteristic (ROC) curve analysis was used to evaluate diagnostic accuracy.

Results
There were 142 benign and 41 malignant lesions, diagnosed in 159 patients (mean age, 43.6 years). Median Kaiser scores ranged between 2 and 5 in benign and 7 and 8 in malignant lesions. For all lesions, the Kaiser score’s accuracy, represented by the area under the curve (AUC), ranged between 86.5 and 90.2. The sensitivity of the Kaiser score was high, between 95.1 and 97.6% for all lesions, and was best in mass lesions. Application of the Kaiser score threshold for malignancy (≤ 4) could have potentially avoided 64 (45.1%) to 103 (72.5%) unnecessary biopsies in 142 benign lesions previously classified as BI-RADS 4.

Conclusions
The use of Kaiser score in high-risk MRI screening reliably excludes malignancy in more than 45% of contrast-enhancing lesions classified as BI-RADS 4.

Key Points
• The Kaiser score shows high diagnostic accuracy in identifying malignancy in contrast-enhancing lesions in patients undergoing high-risk screening for breast cancer.
• The application of the Kaiser score may avoid > 45% of unnecessary breast biopsies in high-risk patients.
• The Kaiser score aids decision-making in high-risk breast cancer MRI screening programs.