bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of Cooperation among Network Partners in Driving the Policy of Human Development throughout the Life of Early Childhood Group, Phichit Province, Thailand
Authors: Chinnawut Siriluk , Sirisunhirun Somboon , Amornsiriphong Somsak , Ploywan Phut , Rugchatjaroen Krish 
Published: February 2025

Background: In developing early childhood children potential, it was not only helps creating a solid foundation for the individual growth, but also a worthwhile investment that provide the highest social returns in the long run. Objective: This research aimed at studying the roles and factors affecting the success of the implementation of the lifelong human development policy for early childhood children of the network in Phichit Province, as well as proposing a model of network partner participation in implementing the lifelong human development policy in Phichit Province. Results: The study results showed that early childhood development in Phichit Province still faced problems in physical and intellectual development, which indicated about the need for integrated actions in many dimensions. Key factors affecting the policy success included 1) clear and concrete policy content, 2) cooperation between the government and the community, 3) participation of local people, and 4) management under effective leadership. Concerning the participation model of the Pichit model network, it focused on the policies adjusting policies to be in line with the local area and creating cooperation from all sectors to support early childhood development effectively, covering the awareness campaign to monitoring and evaluation. Conclusion: The "Phichit Model" was an example of an integrated guideline to human resource development throughout the life which was in line with the 20-year National Strategic Plan. The sustainability of early childhood development required collaboration from all sectors to be able to adapt and acted effectively and responded to the needs of diverse areas.
Risk Management on Infrastructure Projects and their Impact on Project Financials
Authors: Sitanggang Oktavianus , Alam Syamsul , . Arifuddin , Aswan Andi 
Published: February 2025

Purpose – This study aims to identify potential risks in infrastructure projects and determine their impact on project costs. The research addresses the financial implications of risk management practices in infrastructure development projects in Indonesia, focusing on operational, political, managerial, and technical risks. Design/methodology/approach – The research employs a mixed-method approach, integrating qualitative and quantitative methodologies. Data collection was conducted using questionnaires and semi-structured interviews to describe and verify the study findings. Additionally, the snowball sampling method was applied to gather data from Indonesian engineers working on infrastructure projects with contractors or consultants. Qualitative data was sourced from a comprehensive review of scientific literature related to risk management. Findings – Based on a survey of 50 construction practitioners, the study finds that infrastructure projects are highly likely to encounter multiple risks. Among these, the risk of principal insolvency has the most significant impact on infrastructure project costs, with an RII score of 3.04. Empirical findings reveal that only seven risk categories, including building structure risks, complaint and protest risks, contractual risks, approval risks, risks arising from service changes, maintenance risks, and vandalism risks, do not significantly affect infrastructure project costs in Indonesia. These risks can be managed through comprehensive project planning, clear contractual documentation specifying standards and specifications, and the inclusion of adjustment clauses. However, 16 other risk categories significantly impact project costs in the Indonesian infrastructure sector. Originality/value – This study extends the research by Fischer et al. (2010) by empirically testing risk categories to assess their impact on project costs. It adopts both quantitative and qualitative research approaches, focusing on the implementation practices of construction contractors within established project risk management frameworks. Practical implications – The findings provide actionable insights for policymakers, standardization boards, and construction practitioners, offering an empirical foundation for developing integrated and standardized risk management systems. These systems aim to enhance transparency and credibility by providing step-by-step instructions for interconnected subprocesses within the overall structure, improving information dissemination and decision-making accuracy.
The Effectiveness of Giving Ginger Drink in Reducing Emesis Gravidarum in Pregnant Women (Case Study)
Authors: Tasripin Mellysa Wulandari 
Published: February 2025

Pregnant mothers experience changes enhancement hormones progesterone, estrogen, and Human Chorionic Gonadotropin (hCG) so give rise to complaints of mother discomfort and nauseous vomiting in the first trimester, namely emesis gravidarum. This study was to know the effectiveness of drinking ginger to overcome nauseous vomiting. The respondents of study were 2 mothers given pregnancy therapy to drink ginger and not given ginger. Pregnant mothers were given 14 days to drink ginger warm and effective reduce nauseous vomit than no given therapy drink ginger. Drinking ginger is effective in overcoming nauseous vomiting in the mother's first trimester of pregnancy.
Pericardium Point 6 Acupressure For Nausea, Vomiting In 1st Trimester Pregnant Women: Case Study
Authors: Permata Annisa Devi 
Published: February 2025

Nausea and vomiting usually occur in the morning, but some occur at any time and at night occur as a result of changes in the endocrine system that occur during pregnancy, especially increased hormones hCG in pregnancy. Data in Indonesia shows that 50% to 80% of pregnant women experience nausea and vomiting and approximately 5%. Pregnant women require treatment for fluid replacement and electrolyte correction. This case study aims to provide nursing services to pregnant women with nausea and vomiting using acupressure. The author uses a descriptive analytical method in the form of a case study approach in patient care which includes assessment, death diagnosis, death planning, death implementation, death evaluation, and use of EBP (Evidence-Based Practice) interventions. Midwives are expected to be able to apply P6 acupressure intervention to pregnant women as a complementary therapy to reduce nausea and vomiting experienced by pregnant women which can be given to pregnant women reduce complaints of nausea and vomiting in the first trimester of pregnancy.
Considerações críticas sobre a presunção de comoriência: um trabalho de resistência contra o simplismo epistemológico
Authors: Quirino Henrique Rabelo 
Published: February 2025

A presunção da comoriência é um instituto jurídico bastante antigo, que remonta a períodos históricos diversos, sendo que, em diversos tempos e ordenamentos, foi utilizado como meio para se solucionar grandes embaraços jurídicos, garantindo a segurança jurídica e a estabilização de expectativas sociais. Este breve artigo tem por objetivo principal analisar, a partir de perspectivas sérias e contra-hegemônicas, o instituto jurídico da presunção de comoriência, inclusive comparando-o com outros, de finalidade similar, instituídos em ordenamentos de diferentes lugares e épocas. Pretende-se, além disso, analisar, mais a fundo, o instituto no contexto do Código Civil de 2002, desafiando as clássicas e supersimplificadas interpretações normalmente encontradas nos manuais de Direito Civil. Nesse sentido, será buscada uma análise crítica do tratamento que comumente se dá a este instituo em certas partes da doutrina e na prática jurídica, inclusive em provas de alguns certames públicos.
Analisis Kinerja Organisasi pada Perspektif Pelanggan Perusahaan Katering
Authors: Mauliddinah Rizqy Nur , Ariyati Putri , Yaqin Muhammad Ainul 
Published: February 2025

Pengukuran kinerja organisasi merupakan elemen krusial dalam pengelolaan bisnis, terutama di industri jasa seperti katering yang sangat kompetitif dan berorientasi pada pelanggan. Penelitian ini bertujuan untuk mengevaluasi kinerja perusahaan katering dengan pendekatan Balanced Scorecard (BSC) pada perspektif pelanggan, serta menggunakan analisis tambahan berupa RFM (Recency, Frequency, Monetary) untuk mengidentifikasi pelanggan bernilai tinggi. Data yang digunakan mencakup jumlah pelanggan, retensi, akuisisi, dan profitabilitas dalam periode enam bulan, yang diolah menggunakan perangkat lunak spreadsheet. Hasil penelitian menunjukkan bahwa meskipun ada peningkatan jumlah pelanggan selama beberapa bulan, retensi dan akuisisi pelanggan masih menghadapi fluktuasi yang menghambat stabilitas pertumbuhan. Analisis profitabilitas memperlihatkan bahwa meskipun perusahaan mencatat kenaikan pendapatan di beberapa bulan, ketidakstabilan tetap terlihat, menunjukkan perlunya strategi peningkatan yang berkelanjutan. Analisis RFM membantu mengkategorikan pelanggan dalam kategori Platinum, Gold, dan Silver, yang masing-masing membutuhkan pendekatan manajemen berbeda. Secara keseluruhan, hasil penelitian ini adalah index kinerja pada perspektif pelanggan beserta kategorisasi pelanggan berdasarkan level.
Deep Learning-Enabled Business Models for Competitive Advantage
Authors: - Md Firoz Kabir , - Md Imran Chowdhury Rana , - Md Towhidul Rahman Faisal , - Md Daiyan Chowdhury , - Md Yousuf Ahmad 
Published: February 2025

This paper explores the transformative potential of deep learning (DL) in reshaping business models and creating sustainable competitive advantages in the digital era. While many firms have invested heavily in deep learning technologies, few have successfully harnessed their full potential to drive economic value creation and appropriation. This study addresses the critical question: How can firms leverage deep learning to create and capture value in a competitive market? Through a systematic review of existing literature and the integration of business model theory, network effects, and the theory of situated AI, this paper proposes a novel framework: Deep Learning-Enabled Business Models for Competitive Advantage. The framework emphasizes the strategic positioning of deep learning within a firm’s business model architecture to activate key business model themes such as novelty, efficiency, complementarity, and lock-in. By leveraging deep learning’s unique capabilities in pattern recognition, predictive analytics, and adaptive learning, firms can create data network effects that enhance customer retention, attract new users, and raise entry barriers for competitors. The study also highlights the importance of grounding and bounding deep learning applications within the firm’s operational and strategic context to ensure alignment with business objectives. Key findings reveal that deep learning is not merely a technological tool but a strategic enabler that can drive innovation, operational efficiency, and long-term competitive advantage. The paper concludes with actionable recommendations for firms seeking to integrate deep learning into their business models, emphasizing the need for dynamic adaptation and continuous reconfiguration to maintain relevance in an ever-evolving market landscape.
Influence of Weather Parameters on Pollen and Nectar Foraging Activity of Apis and Non-Apis Species of Honey Bees in Wild and Cultivated Varieties of Jamun (Syzygium cumuni L. Skeels)
Authors: G Eswarappa , B Gagan , S Anitha , R K Somashekar , K S Jagadish 
Published: February 2025

The study on influence of weather parameters on pollen and nectar foraging activity of Apis and non-Apis species of honey bees in wild and cultivated varieties of jamun revealed that two peaks in nectar forager activity of A. dorsata, A. florea and A. cerana was recorded, the first peak during 0800-1200hr and second peak during 1400-1800hr, whereas in the case of T. iridipennis, one peak during 0800-0900hr was observed. Only one peak in the pollen forager of A. dorsata, A. florea and A. cerana was recorded during 0900-1200/1300hr, where as in case of T. iridipennis, two peaks were observed, the first peak during 1000-1200hr and the second peak during 1500-1800hr. The nectar foragers of T. iridipennis showed a significant negative, a significant positive and a significant negative correlation at five per cent level of significance with hourly temperature, relative humidity and wind speed. The nectar foragers of A. cerana had a significant positive correlation on wild S. cumini at GKVK at five per cent level of significance with hourly wind speed. A highly significant positive, a significant positive and a non-significant negative correlation at one and five per cent level of significance existed between the number of pollen foragers of T. iridipennis with hourly wind speed, temperature and relative humidity. Out of studied Apis and non-Apis bees, the relative humidity and wind speed affected the pollen and nectar foragers of T. iridipennis on wild and cultivated varieties of jamun.
Transforming growth factor‐β1: A lesion‐associated cytokine of the nervous system
Authors: Kiefer Reinhard , Streit Wolfgang J. , Toyka Klaus V. , Kreutzberg Georg W. , Hartung Hans‐Peter 
Published: July 2002

AbstractLesions to the nervous system are nearly universally accompanied by a glial response involving both microglia and astrocytes. The growth and immunoregulatory cytokine transforming growth factor‐β1 (TGF‐β1) has potent effects on glial cells in vitro and may play a role in regulating glial activation in vivo. Though present only at very low levels in the normal brain, TGF‐β1 mRNA is strongly upregulated in a number of different experimental models suitable to study glial responses. Following axotomy of the facial nerve of the rat, about a three‐fold increase of TGF‐β1 mRNA in the regenerating nucleus was observed with a time‐course closely matching that of glial activation. Putative activated microglial cells are the major cellular source as revealed by in‐situ hybridization. TGF‐β1 was also found to be upregulated around brain tumors, in the spinal cord in response to peripheral nerve inflammation and in the postishemic hippocampus. In all systems investigated, TGF‐β1 mRNA could be localized predominantly to cells with the typical nuclear morphology of microglia. In the peripheral nervous system, nerve transection leads to a massive increase in TGF‐β mRNA expression both proximal and distal to the cut site. However, whereas TGF‐β1 mRNA is restricted to the nerve stump in the proximal segment, expression is diffuse and widespread throughout the denervated distal segment where it was localized mainly to cells with macrophage morphology. Thus, TGF‐β appears to be uniformly expressed by microglial cells of the central nervous system whenever these cells become activated and might be required for microglial cells to control their own activation and cytotoxicity. In addition, our data suggest that TGF‐β1 might also be regulating cellular responses in the peripheral nervous system in response to injury.
Exposure to lead‐acetate modulates the developmental expression of myelin genes in the rat frontal lobe
Authors: Zawia N.H. , Harry G.J. 
Published: July 2002

AbstractPostnatal exposure to high levels (4%) of lead (Pb) have been shown to disrupt myelin formation and result in abnormal conduction of nerve impulses, components necessary for information processing in the CNS. To investigate whether the pathological changes in myelin, we have might be partially mediated by modulations of the expression of genes involved in CNS myelin, we have examined the developmental profiles of the proteolipid protein (PLP) and myelin basic protein (MBP), two major structural constitents of CNS myelin and 2′,3′‐cyclic nucleotide 3′ phosphodiesterase (CNP), a non‐structural enzyme associated with myeline formation. Rat pups were postnatally exposed, from birth to weaning, to moderate amounts of Pb (0.2%), in the drinking water of the dam, and their frontal cortices were assayed for changes in the expression profile of the above genes by Northern Analysis. On PND 20, Pb resulted in a dramatic stimulation of the mRNA levels of PLP and a small increase in MBP mRNA levels, but had no effect on the CNP message. These data suggest that moderate levels of Pb selectively interfere with the gene expression of structural proteins of CNS myelin and may thus influence the composition of myelin in this way.
Cocultures of meningeal and astrocytic cells—A model for the formation of the glial‐limiting membrane
Authors: Struckhoff Gernot 
Published: July 2002

AbstractThe glial‐limiting membrane at the border of the central nervous system (CNS) consists of glial endfeet covered by a basal lamina. The formation of the glia limitans seems to be controlled by adjacent meninges but only little is known about this interaction. In the present study astrocytes and meningeal cells were investigated in vitro to see if cocultures of these cells can serve as a suitable model for the differentiation of the glial‐limiting membrane and can be used to define the conditions under which the glial‐limiting membrane develops. The following observations were made in cocultures of meningeal and astrocytic cells of two‐day‐old rats: (i) epithelioid astrocytes were transformed into stellate cells; (ii) single colonies of proliferating epithelioid astrocytes were generated; (iii) the area around these colonies becomes devoid of meningeal cells, which seem to form a circular border around the astroglial islands; (iv) from the glial colonies long thin glial processes grow towards the surrounding meningeal cells, terminating at the site of contact; (v) in the contact zone between meningeal cells and astrocytes irregular shaped deposits of electron dense material resembling a basal lamina were seen. These observations indicate that indeed a structure resembling a glial‐limiting membrane develops in cocultures of meningeal and astrocytic cells. Its formation depends on the balance of growth promoting effects of meningeal cells on astrocytes and growth inhibiting effects of astrocytes on meningeal cells. Both activities can be enriched from conditioned media of pure astrocytic or meningeal cell culture. The proposed model of meningo‐astrocytic cocultures may be a helpful instrument for further investigations on the formation of the glia limitans.
Effects of ATP analogues and basic fibroblast growth factor on astroglial cell differentiation in primary cultures of rat striatum
Authors: Abbracchio M.P. , Ceruti S. , Langfelder R. , Cattabeni F. , Saffrey M.J. , Burnstock G. 
Published: July 2002

AbstractWe have used primary cultures of rat striatum to study the effects of ATP analogues on the elongation of astrocytic processes, a parameter of astroglial cell differentiation. Parallel studies were performed with basic fibroblast growth factor, a known regulator of astroglial cell function. After three days in culture, both the growth factor and αβ‐methylene‐ATP induced dramatic increases in the mean length of astrocytic processes/cell. For both agents, effects were dose‐dependent. The effect of αβ‐methylene‐ATP was antagonized by the trypanoside suramin and mimicked by 2‐methyl‐thio‐ATP, suggesting the involvement of a suramin‐sensitive P2‐purinoceptor. Neither an additive nor a synergistic effect between αβ‐methylene‐ATP and basic fibroblast growth factor on the elongation of processes was detected in cultures exposed to both agents. Indeed, an inhibition with respect to the effects induced by either agent alone was recorded, suggesting that the growth factor and the purine analogue can modulate astrocytic differentiation by activation of common intracellular pathways.It is concluded that, like basic fibroblast growth factor, ATP can promote the maturation of astrocytes towards a more differentiated phenotype characterized by the presence of longer astrocytic processes. These findings might have interesting implications for astroglial cell differentiation during brain development and for ischemia‐ and trauma‐associated hypergliosis.
Effects of chronic and acute oestrogen treatment on the developing noradrenaline‐containing nerves of the rat uterus
Authors: Brauer M.M. , Corbacho A.M. , Burnstock G. 
Published: July 2002

AbstractThe developing noradrenaline‐containing (NA‐C) sympathetic nerves of the rat uterus were analyzed following acute and chronic treatment with oestrogen. Histochemical methods were used in association with nerve density measurements and biochemical assays. For comparative purposes, noradrenaline (NA) levels were measured in the urinary bladder and right auricle following chronic oestrogen treatment. Acute treatment was performed by s.c. administration of a single dose of 40 μg oestradiol cypionate on the 25th day of age. Chronic treatment consisted of four doses of 10 μg oestradiol on days 10, 15, 20 and 25 of postnatal development. Both acute‐ and chronic‐treated animals were killed at 28 days of age. The main biochemical findings were the following: (a) both acute and chronic oestrogen treatment increased the weight of the uterine horn, parametrial tissue and uterine cervix; (b) in the uterine horn, the total content of NA was reduced following both oestrogen treatments. However, the degree of reduction was greater after chronic treatment; (c) in the parametrial tissue, the NA levels were reduced only after chronic treatment; (d) in the cervix, the NA total content was increased after both treatments; (e) in the urinary bladder, there was a parallel increase between organ growth and NA content following chronic oestrogen treatment; (e) in the auricle neither the tissue weight nor the total content of NA were changed by chronic estrogen treatment.Histochemical studies showed that: (a) acute treatment with one single dose of oestradiol, provoked a marked reduction in the density of NA‐C nerves associated with the myometrial and parametrial smooth muscle, without affecting the innervation of blood vessels; (b) following chronic treatment, the only fibers we were able to recognize were those associated with blood vessels. These fibers were thinner and less intensely fluorescent than in controls. Results are interpreted considering the differential sensitivity of uterine nerves to sex hormones. A possible involvement of oestrogen in changes of noradrenergic innervation of the uterus following puberty is discussed.