bluuebunny/crossref_metadata_2025_split huggingface dataset:
The SEM-4 Transcription Factor Is Required for Regulation of the Oxidative Stress Response in Caenorhabditis elegans
Authors: Rafikova Adilya , Hu Queenie , Kubiseski Terrance J 
Published: July 2020

Abstract
Oxidative stress causes damage to cells by creating reactive oxygen species (ROS) and the overproduction of ROS have been linked to the onset of premature aging. We previously found that a brap-2 (BRCA1 associated protein 2) mutant significantly increases the expression of phase II detoxification enzymes in C. elegans. An RNAi suppression screen to identify transcription factors involved in the production of gst-4 mRNA in brap-2 worms identified SEM-4 as a potential candidate. Here, we show that knockdown of sem-4 suppresses the activation of gst-4 caused by the mutation in brap-2. We also demonstrate that sem-4 is required for survival upon exposure to oxidative stress and that SEM-4 is required for expression of the transcription factor SKN-1C. These findings identify a novel role for SEM-4 in ROS detoxification by regulating expression of SKN-1C and the phase II detoxification genes.
Presupozycje jako formy manipulacji językowej
Authors: Witek Agnieszka 
Published: July 2020

Cel: Celem pracy jest przybliżenie pojęcia presupozycji i przedstawienie jej użycia w kontekście manipulacji językowej w mediach na wybranych przykładach. Artykuł przedstawia różnorodność presupozycji jako formy językowej. Praca ukazuje również mnogość rodzajów tej figury pragmatycznej.
Metoda: Analiza jakościowa posłużyła do przybliżenia techniki posługiwania się presupozycją jako formą manipulacji. Szerokiemu badaniu jakościowemu poddane zostały dwa przykłady, które zaistniały w dyskursie medialnym. Ważnym aspektem analizy jest również ukazanie kontekstu wypowiedzi, dzięki czemu odbiorca ma świadomość, w jaki sposób i w jakich okolicznościach przekaz zaistniał.
Wyniki: Analiza wykazała, w jaki sposób ludzie mediów i polityki stosują presupozycje, by w podświadomości odbiorcy zakomunikować swój osąd, bez ukazania go w sposób bezpośredni. Różnorodność tej figury pragmatycznej przyczynia się do różnorodności jej zastosowań w dyskursie medialnym.
Wnioski: Umiejętnie zastosowana presupozycja stanowi doskonałą praktykę manipulacyjną. Zgłębianie tego tematu przyczyni się do poszerzenia świadomości odbiorców wypowiedzi medialnych, którzy nie posiadając odpowiedniej wiedzy, stają się dobrym materiałem do stosowania praktyk manipulacyjnych. Presupozycja ze względu na swoją specyfikę niełatwa jest do odszyfrowania, co czyni ją interesującym przedmiotem badań w kontekście manipulacji.
Perceptions and attitudes towards gym use and physical activity in young men with haemophilia
Authors: Pembroke Luke , Woollard Laurence 
Published: July 2020

Abstract

Introduction
A growing body of evidence supports the recommendation of both physiotherapy and physical activity in people with haemophilia. Physical benefits include increasing strength and flexibility and reducing the risks of osteoporosis, arthropathy, and intramuscular and joint bleeds; social benefits have also been observed. However, anecdotal evidence suggests that people with haemophilia may still be averse to engaging with physical activity due to fears of causing bleeding, joint pain and joint damage.

Methodology
Qualitative interviews were conducted with young men with haemophilia treated at comprehensive care centres in London, to explore and identify the reasons behind risk-averse behaviours towards exercise and physical activity. The interview questions were designed to prompt discussion and capture opinions relating to participants’ physical activity and gym membership/use, and the degree to which their haemophilia impacts on both.

Results
Ten participants were interviewed. Preferred activities were variable, with five participants describing themselves as very physically active, three moderately active, and two reporting little physical activity; four described themselves as ‘not gym-confident’. Seven participants described themselves as highly or moderately motivated to undertake physical activity, with motivations including weight loss and getting fit for summer holidays. However, there was some anxiety around weight-bearing exercise due to the fear of pain or injury. All participants had been exposed to personal trainers (PTs) and recognised the importance of being properly introduced to training equipment but felt that PTs were too expensive for them. The majority of participants reported sports-related injuries and self-perceived limitations on activity due to their personal/individual experience of living with haemophlia. Physiotherapists were often the first point of contact for advice and support on safe physical activity. All participants recognised the benefits of physical activity and had been encouraged in this by their physiotherapists.

Conclusion
Young men with haemophilia are keen to use the gym as part of their personal fitness regimens. The ongoing safety concerns of health care professionals warrants further research.
Design Research to Support Fourth Grader Learn Addition of Mixed Numbers in RME Learning
Authors: Windria Hening , Zulkardi Zulkardi , Hartono Yusuf 
Published: July 2020

Mixed numbers andfraction in general have been a problem for students not only in understanding the concept of itself, but also in understanding the operation of it, such as addition.Thus, supporting students in learning addition of mixed numbers is needed. the aim of this study is to develop a local instructional theory and materials related to supporting students in learning addition mixed numbers. In order to develop the theory, this studyused design research method. The is collected by generatingthe video recording of the learning process, student’s written work, students’ result from pretest and posttest, the result of interview, and also the fields note from the observation. The participants of this study are fourth grade students in one of private elementary school in Palembang. From the study,it can be seen that students have built the reasoning in addition mixed numbers. Some of them are able to use the distribution principle and use equivalence fractions when they adding the mixed numbers, and some of them are directly used the algorithm of changing mixed number to improper fractions. However, it is insufficient to say that the fractions number line has a big role in the students’ finding.
EEG in genetic generalized epilepsies
Authors: Nogovitsyn V. Yu. , Sharkov A. A. 
Published: July 2020

Genetic, or idiopathic, generalized epilepsies (GGEs or IGEs) includes childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and epilepsy with generalized tonic-clonic seizures alone (GTCS-a).Aim. to characterize the capabilities of electroencephalography (EEG) for the diagnosis of various forms of genetic generalized epilepsyMaterials and methods. Literature data in Pubmed, Google Scholar was analyzed. In addition, own observations and clinical cases were systematized.Results. The article presents the data of morphology and topography of spike-wave discharges, as well as other patterns of EEG in the GGE – poly-spike activity, photoparoxysmal response, occipital intermittent rhythmic delta activity (OIRDA), fixation-off sensitivity and generalized paroxysmal fast activity (GPFA), as well as epileptiform K-complexes, the allocation of which in an independent pattern is questioned by a number of neurophysiologists. The differences between interictal and ictal activity in the GGE are discussed in detail; electroencephalogram (EEG) informativity modifiers are considered. The morphology of atypical features in the GGE is considered. The role of EEG in the differential diagnosis of CAE, JAE, JME, GTCS alone with the description of typical, atypical features, study scenarios and diagnostic criteria for each form are considered.Conclusions. Typical EEG features of GGE significantly simplify the differential diagnosis of electroclinical syndromes. There are “non-classical” features of EEG in the GGE, which do not contradict the diagnosis. To reveal the peculiarities of epileptiform discharges distribution, video EEG monitoring with night-time sleep and the use of several modality stimuli is preferable. Incorrect interpretation of EEG is dangerous for the patient.
Evidence-based Claims Adjudication of Traffic Injury Claims in Ontario: Shifting the Focus from Cost to Care
Authors: Moodley Keshini , Cancelliere Carol , Power Robert , Côté Pierre 
Published: July 2020

Background.— In the Ontario automobile insurance system, claims adjusters decide whether to approve, partially approve or deny funding for clinical interventions submitted by healthcare practitioners. Typically, these decisions are made based on cost, without considering the evidence on the effectiveness and safety of the interventions.
Objective.— Develop an evidence-based claims adjudication framework, which can be used by automobile insurers to integrate clinical evidence into claims adjudication.
Method.— We adapted the evidence-based medicine framework developed by Sackett et al1 to develop a framework for evidence-based claims adjudication.
Conclusion.— An evidence-based claims adjudication framework may help insurers make claim decisions that will promote recovery of individuals injured in traffic collisions and reduce claims costs. The effectiveness and implementation of the framework needs to be evaluated.
TuningS-Wave Velocity Structure of Deep Sedimentary Layers in the Shimousa Region of the Kanto Basin, Japan, Using Autocorrelation of Strong-Motion Records
Authors: Chimoto Kosuke , Yamanaka Hiroaki 
Published: July 2020

ABSTRACTThe autocorrelation of ambient noise is used to capture reflected waves for crustal and sedimentary structures. We applied autocorrelation to strong-motion records to capture the reflected waves from sedimentary layers and used them for tuning the S-wave velocity structure of these layers. Because a sedimentary-layered structure is complicated and generates many reflected waves, it is important to identify the boundary layer from which the waves reflected. We used spectral whitening during autocorrelation analysis to capture the reflected waves from the seismic bedrock with an appropriate smoothing band, which controls the wave arrival from the desired layer boundary. The effect of whitening was confirmed by the undulation frequency observed in the transfer function of the sedimentary layers. After careful determination of parameters for spectral whitening, we applied data processing to the strong-motion records observed at the stations in the Shimousa region of the Kanto Basin, Japan, to estimate the arrival times of the reflected waves. The arrival times of the reflected waves were found to be fast in the northern part of the Shimousa region and slow in the western and southern parts. These arrival times are consistent with those obtained using existing models. Because we observed a slight difference in the arrival times, the autocorrelation function at each station was used for tuning the S-wave velocity structure model of the sedimentary layers using the inversion technique. The tuned models perfectly match the autocorrelation functions in terms of the arrival time of the reflected waves from the seismic bedrock.
Percutaneous Coronary Interventions in Patients With ST-Elevation Myocardial Infarction: 10-Years Follow-up
Authors: Bessonov I. S. , Kuznetsov V. A. , Dyakova A. O. , Gorbatenko E. A. , Evlampieva L. G. , Kicherova O. A. , Reikhert L. I. , Nyamtsu A. M. , Gultyaeva E. P. 
Published: July 2020

Aim To study long-term results and to identify predictors of death in patients with ST-segment elevation acute myocardial infarction (STEMI) who underwent endovascular revascularization.Materials and methods This study included 283 patients registered in the hospital registry of percutaneous coronary interventions (PCI) for STEMI from 2006 through 2009. Analysis of 10-year results included all-cause and cardiovascular death rate, incidence of recurrent myocardial infarction (MI), repeated revascularization, stroke, stent restenosis and thrombosis. Also, a composite endpoint МАССЕ (Major Adverse Cardiovascular and Cerebrovascular Events) was evaluated, which included death, recurrent MI, repeated PCI, stent restenosis and thrombosis, coronary bypass, and stroke.Results Information about the health condition was provided by 204 (72.1 %) patients. Mean follow-up period was 120.1±9.5 months. All-cause mortality was 25.5 % with cardiovascular death determined in 19.1 % of cases. Recurrent MI developed in 21.6 % of patients; in 1.5 % of cases, recurrent MI resulted from thrombosis of previously implanted stents. Repeated PCI was performed for 31.9 % of patients; in 13.7 % of cases, the PCI was performed for stent restenosis. Coronary bypass was performed for 5.4 % of patients. Incidence of stroke was 10.3 %. Major cardiovascular and cerebrovascular complications (МАССЕ) during the follow-up period were determined in 60.3 % patients. According to the Cox proportional hazards regression model, age ≥65 years (odds ratio (OR), 3.75 at 95 % confidence interval (CI) from 1.75 to 8.03; р=0.001) and incomplete coronary revascularization (OR, 3.09 at 95 % CI from 1.52 to 6.30; р=0.002) were independent predictors of death based on data of the 10-year observation.Conclusion Therefore, at 10 years following endovascular revascularization, STEMI patients showed a moderate death rate with a high incidence of major cardiovascular and cerebrovascular complications. The leading causes for fatal outcomes were recurrent cardiovascular complications. The major predictors of death for the coming 10-year period included age ≥65 years and incomplete myocardial revascularization.
Acendendo as Luzes: uma inovação no Cuidado a Saúde dos Pacientes Oncológicos, Familiares e Equipe.
Authors: Chagas Natanael , Locateli Gelvani , Gato Caroline Menzel , De Oliveira Gabriela Gonçalves , Zenevicz Leoni Terezinha 
Published: July 2020

Resumo: As práticas Integrativas e complementares têm se incorporado ao sistema de saúde de maneira significativa, na assistência a saúde dos pacientes, especialmente na área da oncologia. O câncer é uma doença devastadora que impacta de maneira negativa na vida do paciente, família e equipe. A utilização das Praticas Integrativas e Complementares (PIC’s) são uma alternativa que complementam os tratamentos convencionais na melhora da qualidade de vida e no cuidado a dimensão espiritual do ser humano. Objetivo: Relatar a experiência de implantação das Terapias Integrativas e Complementares através do Projeto de Extensão Luzes.Métodos: as atividades realizadas são Reiki, Auriculoterapia, massagem laboral, meditação, grupo de oração, música e canto, Bio Energetics Medicine, Contação de histórias, confecção de origamis, avaliação da saúde bucal, construção de Mandalas e pinturas. As PIC’s são desenvolvidas por um grupo de 136 voluntários dentre docentes, discentes e profissionais de diferentes áreas e da comunidade em geral. Desde sua implantação em Agosto de 2018 já atendeu mais de 1700 pessoas. É desenvolvido dentro do Hospital Regional do Oeste de Chapeco SC nos setores de Oncologia, Quimioterapia e Radioterapia. Resultados: as terapias integrativas e complementares são reconhecidas como benéficas pelos pacientes, familiares e profissionais. Consideradas aliadas na melhora da qualidade de vida durante o período de internação e tratamento. Também citada como uma maneira diferenciada de assistência a dimensão espiritual porque propicia a formação de vinculos mais empáticos entre profissionais, pacientes e família. Observa-se também uma maior qualificação no processo de formação profissional dos acadêmicos dos cursos de Enfermagem e Medicina da UFFS.Conclusões: A utilização das praticas integrativas e complementares no ambiente hospitalar foram sem sombra de dúvidas um desafio. Devemos reconhecer que valeu o desafio de implantar as Terapias Integrativas e Complementares que aliadas ao tratamento convencional trouxeram benefícios impares a tríade paciente, família e profissional. Um espaço de pratica das PIC’s possibilita a formação de recursos humanos voltados ao SUS, com uma visão ampliada ao processo saúde-doença e mais competentes e comprometidos com a saúde integral do ser humano.
KLASIFIKASI NAÏVE BAYES UNTUK MENDIAGNOSIS PENYAKIT PNEUMONIA PADA ANAK BALITA (STUDI KASUS : UPTD PUSKESMAS SUKARAJA SUKABUMI)
Authors: Rahmawati Ami , Wintana Dede , Suhada Satia , Gunawan Gunawan , Sulaiman Hamdun 
Published: July 2020

<p><em>Pneumonia is a contagious infectious disease that is the leading cause of death in toddlers in the world. In developed countries, there are 4 million cases each year, totaling 156 million cases of pneumonia every year worldwide. Pneumonia is caused by, among others, bacteria, viruses, fungi, exposure to chemicals or physical damage from the lungs, as well as indirect effects from other diseases. Pneumonia is characterized by symptoms of coughing and / or difficulty breathing such as rapid breathing, and pulling the lower chest wall inward. Therefore, early detection of pneumonia in children under five is very necessary in order to be able to prevent and cope with the disease into a serious stage as the purpose of this study is to diagnose pneumonia in toddlers using data mining classification, the naïve Bayes algorithm. Of the 118 cases consisting of 113 cases of patients diagnosed with pneumonia and 5 cases of patients who were not diagnosed with pneumonia, an accuracy value of 98% was obtained, so it can be interpreted that the naïve bayes algorithm has a good correlation with the attributes contained in the dataset.</em></p><p><em><strong>Keywords: </strong></em><em>Naïve Bayes Algorithm, Pneumonia.</em></p><p><em>Pneumonia adalah penyakit infeksi menular yang merupakan penyebab utama kematian pada balita di dunia. Di negara maju terdapat 4 juta kasus setiap tahun hingga total di seluruh dunia ada 156 juta kasus pneumonia anak balita setiap tahun. Pneumonia antara lain disebabkan oleh bakteri, virus, jamur, pajanan bahan kimia atau kerusakan fisik dari paru-paru, maupun pengaruh tidak langsung dari penyakit lain. Pneumonia ditandai dengan gejala batuk dan atau kesulitan bernapas seperti napas cepat, dan tarikan dinding dada bagian bawah ke dalam. Oleh Karena itu, deteksi dini penyakit pneumonia pada anak balita sangat diperlukan</em><em> </em><em>agar dapat mencegah dan menanggulangi penyakit tersebut kedalam tahap yang serius</em><em> seperti tujuan p</em><em>enelitian ini </em><em>yaitu</em><em> untuk mendiagnosis penyakit pneumonia pada anak balita menggunakan klasifikasi data mining yaitu algoritma naïve bayes. Dari 118 kasus yang terdiri dari 113 kasus pasien yang terdiagnosis pneumonia dan 5 kasus pasien yang tidak terdiagnosis pneumonia maka diperoleh nilai akurasi sebesar 98%, sehingga dapat diartikan bahwa algoritma naïve bayes memiliki korelasi yang baik dengan atribut yang terdapat pada dataset.</em></p><p><em><strong>Keywords: </strong></em><em>Naïve Bayes Algorithm, Pneumonia.<strong></strong></em></p><p> </p><p><em><br /></em></p>
PEMODELAN ENTERPRISE RESOURCE PLANNING MENGGUNAKAN ODOO PADA Z-TECH KOMPUTER
Authors: Purwaningtias Fitri , Mukmin Chairul 
Published: July 2020

<p><em>Z-Tech Computers is a company engaged in the sale of computers and accessories. At present the Z-Tech Computer system runs on a buying and selling process carried out conventionally (manually). This condition occurs in the stock control process. The condition that occurs in Z-Tech Computers is information on the placement of goods that are not organized. This information causes problems that arise inaccurately information on stock data and the position of the finished goods attracts losses for the company. For this reason, in this research information modeling is carried out using an integrated modeling language to describe the needs of buying and selling. The results of modeling carried out are implemented in the form of enterprise resource planning (ERP) using the Odoo Application. UML and implementation using Odoo can be run as needed. Because Odoo has a variety of integrated modules, both customer management, accounting, sales, and even purchasing modules</em><em>.</em></p><p><em><strong>Keywords</strong></em><em>: Enterprise Resource Planning, Odoo, Unified Modeling Language</em> </p><p><em>Z-Tech Komputer merupakan perusahaan yang bergerak dalam penjualan komputer dan aksesorisnya. Saat ini pada Z-Tech Komputer sistem berjalan pada proses pembelian </em><em>dan penjualan </em><em>dilakukan secara konvensional (manual). </em><em>Kondisi tersebut terjadi terutama pada proses pengekan stok. Kondisi lain yang terjadi yaitu pada </em><em>Z-Tech Komputer yaitu informasi penempatan barang yang ada tidak teroganisir</em><em>. Kondisi tersebut menimbulkan permasalahan</em><em> </em><em>berupa tidak akuratnya informasi data stok dan posisi barang sehingga</em><em> menimbulkan kerugian bagi perusahaan</em><em>. Untuk itu dalam penelitian ini dilakukan pemodelan informasi menggunakan unified modeling language unutk menjabarkan kebutuhan pada pembelian dan penjualan</em><em>. </em><em>Hasil pemodelan yang dilakukan diimplementasikan dalam bentuk enterprise resource planning (ERP) menggunakan Aplikasi Odoo. Dari hasil implementasi menunjukkan bawah pemodelan UML dan implementasi menggunakan Odoo dapat berjalan sesuai kebutuhan. Karena Odoo memiliki beragam modul yang saling terintegrasi, baik modul manajemen pelanggan, akuntansi, penjualan, dan bahkan pembelian.</em></p><p><em><strong>Kata kunci</strong></em><em>: Enterprise Resource Planning, Odoo, Unified Modeling Language</em></p>