bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visioning a hospitality-oriented patient experience (HOPE) framework in health care
Authors: Hunter-Jones Philippa , Line Nathaniel , Zhang Jie J. , Malthouse Edward C. , Witell Lars , Hollis Brooke 
Published: April 2020

PurposeThis paper considers the question: what would happen if healthcare providers, like their counterparts in the hospitality industry, adopted the principles of customer experience management (CEM) in order to facilitate a more holistic and personalized patient experience? It proposes an alternative vision of the patient experience by adding to an emerging hospitality–healthcare literature base, this time focusing upon CEM. A hospitality-oriented patient experience (HOPE) framework is introduced, designed to enhance the patient experience across all the touchpoints of the healthcare journey.Design/methodology/approachThis is a conceptual paper that draws upon three distinct literatures: hospitality literature; healthcare literature; and CEM literature. It utilizes this literature to develop a framework, the HOPE framework, designed to offer an alternative lens to understanding the patient experience. The paper utilizes descriptions of three unique patient experiences, one linked to chronic pain, a second to gastro issues and a third to orthopedic issues, to illustrate how adopting the principles of hospitality management, within a healthcare context, could promote an enhanced patient experience.FindingsThe main theoretical contribution is the development of the HOPE framework that brings together research on CEM with research on cocreative customer practices in health care. By selecting and connecting key ingredients of two separate research streams, this vision and paradigm provide an alternative lens into ways of addressing the key challenges in the implementation of person-centered care in healthcare services. The HOPE framework offers an actionable roadmap for healthcare organizations to realize greater understanding and to operationalize new ways of improving the patient experience.Originality/valueThis paper applies the principles of hospitality and CEM to the domain of health care. In so doing it adds value to a hospitality literature primarily focused upon extensive employee–customer relationships. To a healthcare literature seeking to more fully understand a person-centered care model typically delivered by a care team consisting of professionals and family/friends. And to a CEM literature in hospitality, which seeks to facilitate favorable employee–customer interactions. Connecting these separate literature streams enables an original conceptual framework, a HOPE framework, to be introduced.
Evaluating mental health literacy and help-seeking behaviours in UK university students: a country wide study
Authors: Gorczynski Paul , Sims-Schouten Wendy , Wilson Clare 
Published: April 2020

Purpose
Despite a high prevalence of mental health problems, few students know where to turn for support. The purpose of this study was to gain a UK wide perspective on levels of mental health literacy amongst university students and to examine the relationship between mental health literacy and mental health help-seeking behaviours.

Design/methodology/approach
A total of 300 university students in the UK participated in this online cross-sectional study. Participants filled out the mental health literacy scale, the general help-seeking questionnaire, Kessler psychological distress scale 10, The Warwick-Edinburgh mental well-being scale and the self-compassion scale: short form.

Findings
Overall, 78 per cent of participants indicated mild or more severe symptoms of distress. Students reported lower levels of mental health literacy when compared to students in other nations. Women, bisexuals, and those with a history of mental disorders indicated high levels of mental health literacy. Participants indicated they were most likely to seek support from intimate partners and least likely to seek support from religious leaders. No significant correlations were found between mental health literacy and help-seeking behaviours. Mental health literacy was not correlated with distress, mental well-being or self-compassion. Help-seeking behaviours were only significantly positively correlated with mental well-being.

Originality/value
Universities should address strategies to improve help-seeking behaviours in an effort to address overall mental well-being. Programmes may wish to help provide students with information about accessing face-to-face support systems. Environmental strategies to foster mental well-being on campus should also be explored.
Chemical, optical and photovoltaic properties of TiO2/reduced graphene oxide photoanodes sensitized with Roselle and N719 dyes for dye-sensitized solar cell application
Authors: Omar Azimah , Fakir Muhamad Saipul , Hamdan Khairus Syifa , Rased Nurul Hidayah , Rahim Nasrudin Abd. 
Published: April 2020

PurposeThe purpose of this paper is to investigate the chemical, optical and photovoltaic properties of titanium dioxide/reduced graphene oxide (TiO2/rGO) photoanodes immersed in natural Roselle and synthetic (N719) dyes for dye-sensitized solar cell (DSSC) application.Design/methodology/approachTiO2mixed with rGO were doctor-bladed on fluorine doped tin oxide (FTO) glass substrate. The chemical and optical properties of TiO2/rGO photoanodes immersed in Roselle and N719 dyes were characterized using Fourier-transformed infrared (FTIR) and ultraviolet–visible (UV–vis) spectroscopies, respectively. The DSSC’s photovoltaic performances were tested using Visiontec Solar I-V tester at standard illumination of AM1.5 and irradiance level of 100 mW/cm2.FindingsThe presence of anthocyanin dye from Roselle flower was detected at 604 nm and 718 nm. TiO2/rGO+Roselle dye sample revealed the smallest energy gap of 0.17 eV for ease of electron movement from valence band to conduction band. The TiO2/rGO-based DSSC fabricated with Roselle dye had a power conversion efficiency,ƞof 0.743 per cent higher than TiO2/rGO photoanode sensitized with N719 dye (0.334 per cent). The obtained J-V curves were analyzed by a single-diode model of Lambert W-function and manual optimization to determine the internal electrical parameters of the DSSC. The average and uncertainty values ofJscandƞwere evaluated at differentRshrange of 1362 Ω to 32 k Ω.Research limitations/implicationsRsvalues were kept constant during optimization work.Originality/valueNew ideality factor of TiO2/rGO-based DSSC was re-determined around 0.9995.
An exploratory study on the components and quality of combined assurance in an integrated or a sustainability reporting setting
Authors: Prinsloo Andre , Maroun Warren 
Published: April 2020

Purpose
This research complements the corporate reporting literature by exploring the different types of assurance, which companies are using to bolster the credibility of their integrated and sustainability reports. A composite quality measure is proposed and this study aims to provide evidence on how combined assurance quality (CAQ) varies among firms.

Design/methodology/approach
Content analysis is used to identify “elements” of combined assurance disclosed in integrated and sustainability reports and company webpages. Results are presented in tabular format and supported by non-parametric tests to evaluate differences in CAQ among firms in more detail.

Findings
Combined assurance is framed as a function of the responsibility of the board of directors to ensure accurate, complete and reliable reporting and the characteristics of different internal and external sources of assurance. Overall, combined assurance models are being designed conservatively. They focus mainly on specific disclosures and are guided by a limited number of assurance methodologies or frameworks instead of taking a more pluralistic approach to verification of integrated and sustainability reports as a whole.

Research limitations/implications
The study is based on combined assurance practices by a sample of large listed companies in a single jurisdiction. An international comparison of combined assurance and the calibration of the proposed quality measure is deferred for future research.

Practical implications
Limitations in existing assurance practices are identified for the consideration of preparers and assurance providers. The quality schematic also offers practitioners, standard-setters and academics an easy-to-apply technique for examining the different elements of a company’s combined assurance model.

Social implications
A better understanding of the quality of combined assurance is essential for users’ to place reliance on integrated and sustainability reports and for informing change to existing assurance practices.

Originality/value
The study is the first to examine the operation and quality of combined assurance. The method used to gauge assurance quality provides a useful basis for a more detailed empirical study on the relevance of combined assurance.
Hysteropexy in the treatment of uterine prolapse stage 2 or higher: laparoscopic sacrohysteropexy versus sacrospinous hysteropexy—a multicentre randomised controlled trial (LAVA trial)
Authors: van IJsselmuiden MN , van Oudheusden AMJ , Veen J , van de Pol G , Vollebregt A , Radder CM , Housmans S , van Kuijk SMJ , Deprest J , Bongers MY , van Eijndhoven HWF 
Published: April 2020

ObjectiveTo investigate whether laparoscopic sacrohysteropexy (LSH) is non‐inferior to vaginal sacrospinous hysteropexy (SSHP) in the surgical treatment of uterine prolapse.DesignMulticentre randomised controlled, non‐blinded non‐inferiority trial.SettingFive non‐university teaching hospitals in the Netherlands, one university hospital in Belgium.Population126 women with uterine prolapse stage 2 or higher undergoing surgery without previous pelvic floor surgery.MethodsRandomisation in a 1:1 ratio to LSH or SSHP, stratified per centre and severity of the uterine prolapse. The predefined inferiority margin was an increase in surgical failure rate of 10%.Main outcome measuresPrimary outcome was surgical failure, defined as recurrence of uterine prolapse (POP‐Q ≥ 2) with bothersome bulging/protrusion symptoms and/or repeat surgery or pessary at 12 months postoperatively. Secondary outcomes were anatomical recurrence (any compartment), functional outcome and quality of life.ResultsLaparoscopic sacrohysteropexy was non‐inferior for surgical failure (n = 1, 1.6%) compared with SSHP (n = 2, 3.3%, difference −1.7%, 95% CI: −7.1 to 3.7) 12 months postoperatively. Overall, anatomical recurrences and quality of life did not differ. More bothersome symptoms of overactive bladder (OAB) and faecal incontinence were reported after LSH. Dyspareunia was more frequently reported after SSHP.ConclusionLaparoscopic sacrohysteropexy was non‐inferior to SSHP for surgical failure of the apical compartment at 12 months’ follow up. Following LSH, bothersome OAB and faecal incontinence were more frequent, but dyspareunia was less frequent.Tweetable abstractLaparoscopic sacrohysteropexy and vaginal sacrospinous hysteropexy have equally good short‐term outcomes.
Review article: Ketoacidosis in the emergency department
Authors: Morton Adam 
Published: April 2020

AbstractDiabetic ketoacidosis, a life‐threatening complication of type 1 diabetes mellitus, is a common cause of presentation to EDs. Two new drug classes have been found to cause ketoacidosis with distinctive presentations. The sodium‐glucose transport protein 2 inhibitors used in the management of type 2 diabetes mellitus may present with ketoacidosis with normal glucose levels. Ketoacidosis with these medications may be prolonged and recur after initial resolution. Checkpoint inhibitors may present with fulminant diabetic ketoacidosis in individuals with previously normal glucose tolerance. Ketoacidosis may also occur as a result of starvation and alcohol excess, as well as a number of rare causes. Other causes of metabolic acidosis with both high and normal anion gap need to be considered in the differential diagnosis of ketoacidosis. Diabetic ketoacidosis may also present with biochemical changes suggestive of myocardial ischaemia and pancreatitis in the absence of these pathologies. The present paper reviews ketone body metabolism, ketone testing and the causes and differential diagnosis of ketoacidosis with particular relevance to emergency medicine.
The influence of crop insurance agents on coverage choices: The role of agent competition
Authors: DeLay Nathan D. , Chouinard Hayley H. , Walters Cory G. , Wandschneider Philip R. 
Published: April 2020

AbstractWe examine how competition among crop insurance agents affects coverage choice in the federal crop insurance program. Agents may influence producers’ insurance decisions to maximize their total compensation. We develop a theoretical model of producer–agent interaction to examine how loss potential, agent compensation mechanisms, and market competition affect the coverage level selected. Using crop insurance unit‐level datasets from five states, we find evidence that agent market concentration and agents’ market share matter in the insurance coverage decisions of producers but that the economic significance of the influence is relatively small. Agent influence over coverage level, premium, and liability choice is generally positive but inconsistent across states, which may be attributable to differences in loss risk and agent compensation mechanisms.
Do drain tubes help reduce risks of post‐operative complications in complex incisional hernia repair (as defined by a recent court ruling)?
Authors: Luo Yuchen , Masood Durr‐e‐Nayab , Mohammed Jinnaah Sara , Tacey Mark , Hodgson Russell 
Published: April 2020

AbstractBackgroundA recent legal case described in the ANZ Journal of Surgery has sparked significant topical interest in drain tube use in incisional hernia repairs in Australia. This study reviews a single centre experience of drain tube use in incisional hernia repair.MethodsData from online clinical records was collected retrospectively from patients that underwent incisional hernia repair from 1 January 2013 to 31 December 2017. ‘Complexity’ factors of smoking, obesity and lower midline incision (as identified by the legal case) were also used to stratify groups.ResultsA total of 410 incisional hernia repair cases were identified during the 5‐year period. Median length of stay of the non‐drain placement group was significantly shorter than that of the drain placement group (2 versus 6 days, P < 0.001). In total, 10.8% of patients with drain suffered from post‐op wound infection compared to 3.6% in patients without a drain tube in‐situ (P = 0.005). Seroma rates were no different with or without a drain (15.7% versus 16.9% P = 0.78). When stratified by ‘complexity’, there was a trend towards increased complications when drains were used.ConclusionDrain tubes were placed in only a small proportion of patients during incisional hernia repairs and were associated with a higher post‐operative wound infection rate. When stratified by the ‘complexity’ factors outlined by the recent legal case, complications in more ‘complex’ patients may actually increase when a drain tube is used.
Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer’s disease
Authors: Toomey Christina E. , Heywood Wendy , Benson Bridget C. , Packham Georgia , Mills Kevin , Lashley Tammaryn 
Published: April 2020

AbstractTriggering receptor expressed on myeloid cells 2 TREM2 was identified as a risk factor for late onset Alzheimer’s disease (AD). Here we compared TREM2 cases with a variant (TREM2+) and cases without a TREM2 variant (TREM2−), considering pathological burden, inflammatory response and altered canonical pathways and biochemical functions between the cohorts. We hypothesised that TREM2+ cases would have a loss of function, indicating an altered inflammatory profile compared to TREM2− cases. Immunohistochemistry was performed using antibodies against Aβ, tau and microglia markers in TREM2+ cases, with and without AD, which were compared to sporadic TREM2− AD, familial AD and neurologically normal control cases. Aβ and tau load were measured along with the composition of Aβ plaques, in addition to microglial load and circularity. Expression and proteomic profiles were determined from the frontal cortex of selected cases. TREM2+ control cases had no Aβ or tau deposition. No differences in the amount of Aβ or tau, or the composition of Aβ plaques were observed between TREM2+ and TREM2− SAD cases. There were no differences in microglial load observed between disease groups. However, the TREM2+ SAD cases showed more amoeboid microglia than the TREM2− SAD cases, although no differences in the spatial relationship of microglia and Aβ plaques were identified. Visualisation of the canonical pathways and biological functions showed differences between the disease groups and the normal controls, clearly showing a number of pathways upregulated in TREM2+ SAD, TREM2− SAD and FAD groups whilst, the TREM2+ controls cases showed a downregulation of the majority of the represented pathways. These findings suggest that the TREM2+ control group, although carrying the TREM2+ variant, have no pathological hallmarks of AD, have altered microglial and expression profiles compared to the TREM2+ SAD cases. This indicates that other unknown factors may initiate the onset of AD, with TREM2 influencing the microglial involvement in disease pathogenesis.
A semantically enriched text mining system for clinical decision support
Authors: Luque Carmen , Luna José M. , Ventura Sebastián 
Published: April 2020

AbstractExisting systems to support decision‐taking process based on textual information of clinical reports are insufficient. Currently, there are few systems that unify different subtasks in a single and user‐friendly framework, easing therefore the clinical work by automating complex and arduous tasks such as the detection of clinical alerts as well as clinical information coding. To address this issue, MiNerDoc is proposed as a new text mining (TM) system whose main objective is to support clinical decision‐taking processes by analyzing textual clinical reports in a unified framework. MiNerDoc is a really alluring TM system that includes two relevant tasks in the medical field, that is, detection of risk factors according to five medical entities (disease, pharmacologic, region/part body, procedure/test, and finding/sign) and automatic prediction of standardized diagnostic codes (MeSH descriptors associated with diseases). MiNerDoc integrates a combination of techniques from the TM discipline along with the terminological and semantic enrichment provided by the MetaMap tool and UMLS metathesaurus. Some study cases as well as a wide experimental analysis on real clinical reports have been carried out to demonstrate the effectiveness and promising performance of MiNerDoc on two different tasks, that is, medical entities recognition (FMeasure 81.54%) and diagnostic classification (FMeasuremic 81.04%).
Assessing the spatial distribution of avian collision risks at wind turbine structures in Brandenburg, Germany
Authors: Bose Anushika , Dürr Tobias , Klenke Reinhard A. , Henle Klaus 
Published: April 2020

AbstractThe risk of collision with wind turbines remains a critical issue for bird conservation. Undoubtedly, for the continued development of wind farms to increase the energy capacity, wind farm locations must be carefully chosen going forward. This can be achieved not only by avoiding areas with higher bird densities but also by avoiding installations at sensitive distances from their ecologically important land‐use types. Through analyses of the Euclidean distances to the different land‐use types, we utilized the random forest (RF) machine learning algorithm to model the distance‐based impacts of wind turbine locations on detected bird collisions for the frequently‐hit groups of birds at WTs. Although, the predicted areas with potential collision risk in total had a small but highly dispersed expanse of ~2,130 km2 across the vast 29,479 km2 area of the federal state. Our results further segregated these assessed areas based on their different probabilities of collision thresholds (between 0 and 1) to only detect the areas with collision probabilities <.05, which were interpreted as the actual “no risk areas”. These “no risk areas” summed to a total of merely 754 km2 of the land space in Brandenburg, suggesting that any further planned additions of wind energy farms in the state that is, the proposed wind turbines, to be suitably positioned only in these safer areas. Additionally, the study also enabled the identification of any existing wind turbines already installed in the remaining less safe 28,725 km2 area of the state. These areas are also essential to be include in the collision detection surveys and bird population dynamic studies. This would further our understanding regarding the deleterious consequences of collisions at the population levels of birds, eventually helping in the formulation of adequate mitigation measures.
A Single and Multiple Ascending Dose Study of Toll‐Like Receptor 7 Agonist (RO7020531) in Chinese Healthy Volunteers
Authors: Luk Andrea , Jiang Qiudi , Glavini Katerina , Triyatni Miriam , Zhao Na , Racek Tomas , Zhu Yonghong , Grippo Joseph F. 
Published: April 2020

Toll‐like receptor 7 (TLR7) agonists modulate broad spectrum immune activity and are evaluated in the treatment of human diseases, including cancer and chronic viral infection. RO7020531, an oral prodrug of a TLR7 agonist, is in clinical development as part of a curative regimen against chronic hepatitis B. We report the safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of RO7020531 in healthy Chinese volunteers following single and multiple ascending doses (SAD and MAD). PK and PD samples were evaluated from four SAD cohorts and 3 MAD cohorts with 10 subjects each (8 active and 2 placebo). Safety and tolerability were monitored throughout the study. A total of 155 adverse events (AEs) were reported in 49 subjects. Fifty‐one AEs in 18 subjects were assessed as treatment‐related. Most of the AEs were mild; nine subjects experienced moderate AEs; there were no severe AEs. In two 150 mg MAD cohorts given every other day (q.o.d.), 7 of 20 subjects experienced pyrexia and were discontinued due to transient asymptomatic lymphopenia, which resolved 24–48 hours postdose. The PK of the active metabolite, RO7011785, increased linearly with dose from 40 mg to 170 mg. There was no PK accumulation following q.o.d. dosing. The PK profile is consistent with observations in white subjects in the global first‐in‐human study. SADs and MADs of RO7020531 resulted in dose‐dependent increases in TLR7 response markers at 100 mg or above. Flu‐like symptoms were associated with higher interferon‐α levels. RO7020531 was safe and acceptably tolerated in healthy Chinese volunteers with a multiple 150 mg q.o.d. dose regimen.