bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of feeding thermally peroxidized lipids on growth performance, lipid digestibility, and oxidative status in nursery pigs
Authors: Kerr Brian J , Lindblom Stephanie C , Zhao Junmei , Faris Richard J 
Published: December 2020

AbstractThree experiments were conducted to evaluate oil source and peroxidation status (experiment 1) or peroxidized soybean oil (SO; experiments 2 and 3) on growth performance, oxidative stress, and digestibility of dietary ether extract (EE). In experiment 1, palm oil (PO), poultry fat (PF), canola oil (CO), and SO were evaluated, while in experiments 2 and 3, only SO was evaluated. Lipids were either an unheated control (CNT) or thermally processed at 90 °C for 72 hr, being added at 10%, 7.5%, or 3% of the diet in experiments 1, 2, and 3, respectively. In experiment 1, 288 pigs (body weight, BW, 6.1 kg) were fed 1 of 8 factorially arranged treatments with the first factor being lipid source (PO, PF, CO, and SO) and the second factor being peroxidation status (CNT or peroxidized). In experiment 2, 216 pigs (BW 5.8 kg) were fed 1 of 6 treatments consisting of 100%, 90%, 80%, 60%, 20%, and 0% CNT SO blended with 0%, 10%, 20%, 40%, 80%, and 100% peroxidized SO, respectively. In experiment 3, 72 pigs (BW 5.8 kg) were fed either CNT or peroxidized SO. Pigs were fed 21 d with feces collected on day 12 or 14 and pigs bled on day 12 blood collection. In experiment 1, an interaction between oil source and peroxidation status was observed for averaged daily gain (ADG) and average daily feed intake (ADFI; P = 0.10) which was due to no impact of feeding pigs peroxidized PO, PF, or SO on ADG or ADFI compared with feeding pigs CNT PO, PF, or SO, respectively; while pigs fed peroxidized CO resulted in reduced ADG and ADFI compared with pigs fed CNT CO. There was no interaction between oil source and peroxidation status, and no lipid source effect on gain to feed ratio (GF; P ≥ 0.84), but pigs fed the peroxidized lipids had a lower GF compared with pigs fed the CNT lipids (P = 0.09). In experiment 2, feeding pigs diets containing increasing levels of peroxidized SO resulted in reduced ADG (quadratic, P = 0.03), ADFI (linear, P = 0.01), and GF (quadratic, P = 0.01). In experiment 3, feeding peroxidized SO at 3% of the diet reduced ADG (P = 0.11) and ADFI (P = 0.13), with no observed change in GF (P = 0.62). Differences in plasma protein carbonyls, glutathione peroxidase, and vitamin E due to feeding peroxidized lipids were inconsistent across the 3 experiments. Digestibility of dietary EE was reduced in pigs fed peroxidized PO or SO (P = 0.01, experiment 1) and peroxidized SO in experiments 2 and 3 (P ≤ 0.02). In conclusion, the peroxidation status of dietary lipids consistently affects growth performance and EE digestibility but has a variable effect on measures of oxidative stress.
The Descriptive Epidemiology and Outcomes of Hospitalized Burn Patients in Southern Turkey: Age-Specific Mortality Patterns
Authors: Gurbuz Kayhan , Demir Mete 
Published: December 2020

Abstract
The current descriptive analysis was designed to document the common epidemiologic characteristics and outcomes of burn injuries, and age-specific mortality patterns covering all age groups admitted for treatment to the Burn Center of Adana City Training and Research Hospital. Medical records were retrospectively analyzed. The patients were stratified into two age groups as pediatric and adults, and then into 10 sub-age groups. Among the 946 patients of the study population, there were 24 mortalities with a mortality rate of 2.5%. Patients within the age range of 70 to 79 years had the highest mortality rate of 33.3%; followed by 60 to 69, 80+, 18 to 29, 10 to 17, and &lt;5 sub-age groups, whose mortality rates were 13.0%, 7.8%, 7.2%, 2.4%, and 0.5%, respectively. In terms of multivariate regression analysis of factors predicting mortality among burn patients in all age groups, fire-flame related burns, age ≥18 years, TBSA burned ≥20% (TBSA ≥20%), the existence of inhalation injury, deep partially/full-thickness burns were found to be significant prognostic factors of mortality. The strongest association was seen in TBSA ≥60% segment (P &lt; .0001), which had 25.9 times more death risk. As expected, a similar trend was detected when the age groups stratified into age groups, and the strongest association was in the 60+ sub-age group (P &lt; .0001), whose had 5.84 times more likely death; followed by 29 to 59 and 18 to 29 sub-age groups, with the odds ratios of 2.12 (95% confidence interval = 1.25–3.61) and 2.08 (95% confidence interval = 1.90–4.05), respectively. Oppose to these findings; the 0 to 17 sub-age group was not found to have a statistically significant effect in predicting mortality.
Navigating the Regulatory Pathways and Requirements for Tissue-Engineered Products in the Treatment of Burns in the United States
Authors: Belsky Kimberly , Smiell Janice 
Published: December 2020

Abstract
In the burn treatment landscape, a variety of skin substitutes, human tissue-sourced products, and other products are being developed based on tissue engineering (ie, the combination of scaffolds, cells, and biologically active molecules into functional tissue with the goal of restoring, maintaining, or improving damaged tissue or whole organs) to provide dermal replacement, prevent infection, or prevent or mitigate scarring. Skin substitutes can have a variety of compositions (cellular vs acellular), origins (human, animal, or synthetically derived), and complexities (dermal or epidermal only vs composite). The regulation of tissue-engineered products in the United States occurs by one of several pathways established by the U.S. Food and Drug Administration, including a Biologics License Application (BLA), a 510(k) (Class I and Class II devices), Premarket Approval (Class III devices), or a human cells, tissues, and cellular and tissue-based products designation. Key differentiators among these regulatory classifications include the amount and type of data required to support a filing. For example, a BLA requires a clinical trial(s) and evaluation of safety and efficacy by the Center for Biologics Evaluation and Research. Applicable approved biological products must also comply with submission of advertising and promotional materials per regulations. This review provides a description of, and associated requirements for, the various regulatory pathways for the approval or clearance of tissue-engineered products. Some of the regulatory challenges for commercialization of such products for the treatment of burns will be explored.
Competitive Harm Crossing Borders: Regulatory Gaps And A Way Forward
Authors: Martyniszyn Marek 
Published: December 2020

Abstract
This article analyses the current regulatory framework governing transnational restrictive business practices. It identifies key gaps that provide room for anticompetitive practices to flourish, causing cross-border transfer of wealth, typically from less affluent states. The economic harm caused by cross-border anticompetitive conduct is significant; international cartels alone caused overcharges exceeding $1.5 trillion in the period 1990–2016. This article offers a series of pragmatic policy recommendations that could narrow existing regulatory gaps. The proposals require no international negotiations and can be implemented domestically. They call for enabling of more assertive and robust extraterritorial enforcement of domestic competition laws and facilitation of positive externalities in that context.
Severe Acute Respiratory Syndrome Coronavirus-2 Pneumonia in a Newborn Treated With Remdesivir and Coronavirus Disease 2019 Convalescent Plasma
Authors: Hopwood Andrew J , Jordan-Villegas Alejandro , Gutierrez Liliana D , Cowart Mallory C , Vega-Montalvo Wilfredo , Cheung Wang Leung , McMahan Michael J , Gomez Michael R , Laham Federico R 
Published: December 2020

Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel pandemic virus. Mounting evidence supports the possibility of vertical transmission, which at the present time appears to be rare. We report a newborn with vertically acquired SARS-CoV-2 who developed acute respiratory failure and received remdesivir and coronavirus disease 2019 convalescent plasma.
Dosimetric feasibility of computed tomography-based image-guided brachytherapy in locally advanced cervical cancer: a Japanese prospective multi-institutional study
Authors: Otani Yuki , Ohno Tatsuya , Ando Ken , Murata Kazutoshi , Kato Shingo , Noda Shin-ei , Murofushi Keiko , Ushijima Hiroki , Yoshida Daisaku , Okonogi Noriyuki , Isohashi Fumiaki , Wakatsuki Masaru , Nakano Takashi 
Published: December 2020

ABSTRACT
The aim of this study was to assess the feasibility of planning dose–volume histogram (DVH) parameters in computed tomography-based 3D image-guided brachytherapy for locally advanced cervical cancer. In a prospective multi-institutional study, 60 patients with stage IIA2–IVA cervical cancer from eight institutions were treated with external beam radiotherapy using central shielding and intracavitary or hybrid (combined intracavitary/interstitial) brachytherapy (HBT). The dose constraints were set as a cumulative linear quadratic equivalent dose (EQD2) of at least 60 Gy for high-risk clinical target volume (HR-CTV) D90, D2cc ≤ 75 Gy for rectum, D2cc ≤ 90 Gy for bladder and D2cc ≤ 75 Gy for sigmoid. The median HR-CTV D90 was 70.0 Gy (range, 62.8–83.7 Gy) in EQD2. The median D2cc of rectum, bladder and sigmoid was 57.1 Gy (range, 39.8–72.1 Gy), 68.9 Gy (range, 46.5–84.9 Gy) and 57.2 Gy (range, 39.2–71.2 Gy) in EQD2, respectively. In 76 of 233 sessions (33%), 23 patients underwent HBT, and the median number of interstitial needles was 2 (range, 1–5). HBT for a bulky HR-CTV (≥40 cm3) significantly improved the HR-CTV D90 compared with intracavitary brachytherapy alone (P = 0.010). All patients fulfilled the dose constrains for target and at risk organs by undergoing HBT in one-third of sessions. We conclude that the planning DVH parameters used in our protocol are clinically feasible.
Games of influence
Authors: Grandi Umberto , Lorini Emiliano , Novaro Arianna , Perrussel Laurent 
Published: December 2020

AbstractIn this paper, we present two models for reasoning about strategic actions in opinion diffusion. In both models, the agents are endowed with goals expressed compactly in a suitably defined language of linear temporal logic and are connected in an influence network which defines the underlying opinion diffusion process. The agents can act by exerting their influence or retain from it: in one case, we assume an initial state of incomplete information about the agents’ opinions, while in the other, we assume that the agents have complete information. We investigate the interplay between simple network structures (e.g. certain acyclic graphs) and the existence of game-theoretic solution concepts for the unanimity aggregator. We also give bounds for the computational complexity of strategic reasoning in both our models on arbitrary networks.
Rapid Deployment of National Guard Alternative Healthcare Facility With Isolation Unit Capabilities in Response to COVID-19
Authors: Torrey Jacob , Orr Jeremy , Florance Jonathon 
Published: December 2020

ABSTRACT
At the direction of Governor Phil Scott, the Vermont National Guard rapidly erected a 400-bed alternative healthcare facility field hospital to increase the state’s medical capacity early in the COVID-19 pandemic when information was limited and cases were rapidly rising across the country. This case study reviews the preparation and management of the alternative healthcare facility’s first COVID-19-positive patient assigned to the 50-bed COVID-19 isolation ward. Despite austere conditions with rudimentary improvements to a nonstandard facility, the ad hoc team composed entirely of members of the Vermont National Guard successfully oversaw patient care from admission to discharge while maintaining a zero-percent transmission rate to staff. While the local civilian medical infrastructure was never overwhelmed and patient census at the facility remained low, this case study highlights the capability of the National Guard enterprise as a community response to pandemic crises.
Scaling relations of fuzzy dark matter haloes – I. Individual systems in their cosmological environment
Authors: Nori Matteo , Baldi Marco 
Published: December 2020

ABSTRACT
Dark matter models involving a very light bosonic particle, generally known as fuzzy dark matter (FDM), have been recently attracting great interest in the cosmology community, as their wave-like phenomenology would simultaneously explain the long-standing misdetection of a dark matter particle and help easing the small-scale issues related to the standard cold dark matter (CDM) scenario. With this work, we initiate a series of papers aiming at investigating the evolution of FDM structures in a cosmological framework performed with our N-body code ax-gadget, detailing for the first time in the literature how the actual scaling relations between solitonic cores and host haloes properties are significantly affected by the dynamical state, morphology, and merger history of the individual systems. In particular, in this first paper we confirm the ability of ax-gadget to correctly reproduce the typical FDM solitonic core and we employ it to study the non-linear evolution of eight FDM haloes in their cosmological context through the zoom-in simulation approach. We find that the scaling relations identified in previous works for isolated systems are generally modified for haloes evolving in a realistic cosmological environment, and appear to be valid only as a limit for the most relaxed and spherically symmetric systems.
Ly α coupling and heating at cosmic dawn
Authors: Mittal Shikhar , Kulkarni Girish 
Published: December 2020

ABSTRACT
The global 21-cm signal from the cosmic dawn is affected by a variety of heating and cooling processes. We investigate the impact of heating due to Ly α photons on the global 21-cm signal at cosmic dawn using an analytical expression of the spectrum around the Ly α resonance based on the so-called ‘wing approximation’. We derive a new expression for the scattering correction and for the first time give a simple close-form expression for the cooling due to injected Ly α photons. We perform a short parameter study by varying the Ly α background intensity by four orders of magnitude and establish that a strong Ly α background is necessary, although not sufficient, in order to reproduce the recently detected stronger-than-expected 21-cm signal by the Experiment to Detect the Global EoR Signal (EDGES) Collaboration. We show that the magnitude of this Ly α heating is smaller than previously estimated in the literature by two orders of magnitude or more. As a result, even a strong Ly α background is consistent with the EDGES measurement. We also provide a detailed discussion on different expressions of the Ly α heating rate used in the literature.
Inferring the lensing rate of LIGO–Virgo sources from the stochastic gravitational wave background
Authors: Mukherjee Suvodip , Broadhurst Tom , Diego Jose M , Silk Joseph , Smoot George F 
Published: December 2020

ABSTRACT
Strong lensing of gravitational waves (GWs) is more likely for distant sources but predicted event rates are highly uncertain with many astrophysical origins proposed. Here, we open a new avenue to estimate the event rate of strongly lensed systems by exploring the amplitude of the stochastic gravitational wave background (SGWB). This method can provide a direct upper bound on the high-redshift binary coalescing rates, which can be translated into an upper bound on the expected rate of strongly lensed systems. We show that from the ongoing analysis of the Laser Interferometer Gravitational-wave Observatory (LIGO)-Virgo and in the future from the LIGO–Virgo design sensitivity stringent bounds on the lensing event rate can be imposed using the SGWB signal. Combining measurements of loud GW events with an unresolved stochastic background detection will improve estimates of the numbers of lensed events at high redshift. The proposed method is going to play a crucial in understanding the population of lensed and unlensed systems from GW observations.
Probing the star formation origin of gamma-rays from 3FHL J1907.0+0713
Authors: Ergin T , Saha L , Bhattacharjee P , Sano H , Tanaka S J , Majumdar P , Yamazaki R , Fukui Y 
Published: December 2020

ABSTRACT
Star-forming (SF) regions embedded inside giant molecular clouds (GMCs) are potential contributors to Galactic gamma-rays. The gamma-ray source 3FHL J1907.0+0713 is detected with a significance of roughly 13σ in the 0.2–300 GeV energy range after the removal of gamma-ray pulsation periods of PSR J1906+0722 from the Fermi-LAT data set of about 10 yr. The energy spectrum of 3FHL J1907.0+0713 is best-fitted to a power-law model with a spectral index of 2.26 ± 0.05. The CO(J = 1−0) data taken by NANTEN2 revealed that 3FHL J1907.0+0713 is overlapping with a GMC having a peak velocity of about 38 km s−1. The best-fitting location of 3FHL J1907.0+0713 is measured to be approximately 0.13 deg away from the Galactic supernova remnant (SNR) 3C 397 and it overlaps with a star that is associated with a bow-shock nebula. We show that there is no physical connection between 3FHL J1907.0+0713, 3C 397, as well as any positional coincidence with the pulsar. The spectrum of 3FHL J1907.0+0713 is fitting to both hadronic and leptonic gamma-ray emission models and the total luminosity at a distance of 2.6 kpc is calculated to be 1.1 × 1034 erg s−1. We also discuss possible SF origins of gamma-rays from 3FHL J1907.0+0713, where SNRs, massive protostar outflows, stellar winds from runaway stars, colliding wind binaries, and young stellar clusters are considered as candidate sources.
Dust reverberation mapping of Z229–15
Authors: Mandal Amit Kumar , Rakshit Suvendu , Stalin C S , Wylezalek Dominika , Patig Markus Kissler , Sagar Ram , Mathew Blesson , Muneer S , Pal Indrani 
Published: December 2020

ABSTRACTWe report results of the dust reverberation mapping (DRM) on the Seyfert 1 galaxy Z229–15 at z = 0.0273. Quasi-simultaneous photometric observations for a total of 48 epochs were acquired during the period 2017 July to 2018 December in B, V, J, H and Ks bands. The calculated spectral index (α) between B and V bands for each epoch was used to correct for the accretion disc (AD) component present in the infrared light curves. The observed α ranges between −0.99 and 1.03. Using cross-correlation function analysis we found significant time delays between the optical V and the AD corrected J, H and Ks light curves. The lags in the rest frame of the source are $12.52^{+10.00}_{-9.55}$ d (between V and J), $15.63^{+5.05}_{-5.11}$ d (between V and H) and $20.36^{+5.82}_{-5.68}$ d (between V and Ks). Given the large error bars, these lags are consistent with each other. However, considering the lag between V and Ks bands to represent the inner edge of the dust torus, the torus in Z229–15 lies at a distance of 0.017 pc from the central ionizing continuum. This is smaller than that expected from the radius luminosity (R−L) relationship known from DRM. Using a constant α = 0.1 to account for the AD component, as is normally done in DRM, the deduced radius (0.025 pc) lies close to the expected R−L relation. However, usage of constant α in DRM is disfavoured as the α of the ionizing continuum changes with the flux of the source.
The impact of Lyα emission line heating and cooling on the cosmic dawn 21-cm signal
Authors: Meiksin Avery , Madau Piero 
Published: December 2020

ABSTRACT
Allowing for enhanced Lyα photon line emission from Population III dominated stellar systems in the first forming galaxies, we show the 21-cm cosmic dawn signal at 10 &lt; $z$ &lt; 30 may substantially differ from standard scenarios. Energy transfer by Lyα photons emerging from galaxies may heat intergalactic gas if H ii regions within galaxies are recombination bound, or cool the gas faster than by adiabatic expansion if reddened by winds internal to the haloes. In some extreme cases, differential 21-cm antenna temperatures near −500 mK may be achieved at 15 &lt; $z$ &lt; 25, similar to the signature detected by the EDGES 21-cm cosmic dawn experiment.
Is GW190521 the merger of black holes from the first stellar generations?
Authors: Farrell Eoin , Groh Jose H , Hirschi Raphael , Murphy Laura , Kaiser Etienne , Ekström Sylvia , Georgy Cyril , Meynet Georges 
Published: December 2020

ABSTRACT
GW190521 challenges our understanding of the late-stage evolution of massive stars and the effects of the pair instability in particular. We discuss the possibility that stars at low or zero metallicity could retain most of their hydrogen envelope until the pre-supernova stage, avoid the pulsational pair-instability regime, and produce a black hole with a mass in the mass gap by fallback. We present a series of new stellar evolution models at zero and low metallicity computed with the geneva and mesa stellar evolution codes and compare to existing grids of models. Models with a metallicity in the range 0–0.0004 have three properties that favour higher black hole (BH) masses. These are (i) lower mass-loss rates during the post main sequence phase, (ii) a more compact star disfavouring binary interaction, and (iii) possible H–He shell interactions which lower the CO core mass. We conclude that it is possible that GW190521 may be the merger of black holes produced directly by massive stars from the first stellar generations. Our models indicate BH masses up to 70–75 M⊙. Uncertainties related to convective mixing, mass loss, H–He shell interactions, and pair-instability pulsations may increase this limit to ∼85 M⊙.
Shell-crossing in a ΛCDM Universe
Authors: Rampf Cornelius , Hahn Oliver 
Published: December 2020

ABSTRACT
Perturbation theory is an indispensable tool for studying the cosmic large-scale structure, and establishing its limits is therefore of utmost importance. One crucial limitation of perturbation theory is shell-crossing, which is the instance when cold-dark-matter trajectories intersect for the first time. We investigate Lagrangian perturbation theory (LPT) at very high orders in the vicinity of the first shell-crossing for random initial data in a realistic three-dimensional Universe. For this, we have numerically implemented the all-order recursion relations for the matter trajectories, from which the convergence of the LPT series at shell-crossing is established. Convergence studies performed at large orders reveal the nature of the convergence-limiting singularities. These singularities are not the well-known density singularities at shell-crossing but occur at later times when LPT already ceased to provide physically meaningful results.