bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitigation of power oscillations using hybrid DE-PSO optimization-based SSSC damping controller
Authors: Behera Soudamini , Barisal Ajit Kumar , Dhal Nirmalya , Lal Deepak Kumar 
Published: December 2019

AbstractThis paper presents an optimal design of a static synchronous series compensator (SSSC)-based controller for damping of low-frequency oscillations in multi-machine power systems. The proposed controller design problem is formulated to the optimization problem. The tuning of controller parameters can be obtained by employing a new hybrid differential evolution and particle swarm optimization (hDE-PSO) algorithm. To justify the effectiveness of the proposed SSSC-based damping controller, three-machine and four-machine power systems have been considered. The hDE-PSO algorithm outperforms in the damping of oscillations over DE and PSO algorithms. Various simulation results are presented and compared for different load disturbances like three-phase fault, load rejection and tripping of one parallel transmission line. The simulation results ensure the robustness of the proposed controller.
Interpretation of Paleozoic paleokarst features in the Arkoma Basin of Oklahoma using 3D seismic and well logs
Authors: Aboaba Olanrewaju , Liner Christopher 
Published: December 2019

Paleokarst regions worldwide are repositories for hydrocarbons, mineral deposits, and groundwater. Time structure maps were generated for the Ordovician Viola Limestone, Mississippian Caney Shale, and Pennsylvanian Jefferson Sandstone and Wapanucka Limestone. Isochron maps indicate pronounced visible sinkhole time thickening in the Viola-Caney and Caney-Jefferson intervals relative to the Jefferson-Wapanucka. Sinkhole features in the Viola exhibit mappable structural depression, characterized by lower positive amplitude, higher seismic variance, and most-negative curvature. Curiously, spatially coincident sinkhole features in the shallower Wapanucka display the opposite characteristics relative to adjacent areas that have not been modified, namely, higher positive amplitude and lower seismic variance with no mappable time structure relief. Seismic amplitude analysis based on well logs and Gassmann modeling indicate that the Viola has a reduction in limestone acoustic impedance inside sinkholes that allows estimation of increased porosity near 10%. Identical analysis for the Wapanucka suggests that no reasonable alteration of the limestone acoustic impedance alone can account for the observed amplitude behavior, implying that the limestone and overlying shale must be altered in sinkhole areas. Some of these interpreted sinkhole features coincide with vertical pipe structures with up to 490 m (1610 ft) vertical extent, diameter up to 520 m (1700 ft), and separation of at least 460 m (1510 ft). We interpret the Viola sinkhole features and associated vertical pipes to be part of a mature epigene karst system. Conversely, the shallower and more subtle Wapanucka sinkholes we interpret as related to an immature mixed karst system with epigene and hypogene elements. Our study indicates for the first time the seismic evidence of pipe features that extend both below and above the Viola and the presence of Wapanucka sinkhole features in the Arkoma Basin of Oklahoma, which provides a better understanding of paleokarst occurrence and its possible impact on resource exploration.
Dual role of Jam3b in early hematopoietic and vascular development
Authors: Kobayashi Isao , Kobayashi-Sun Jingjing , Hirakawa Yuto , Ouchi Madoka , Yasuda Koyuki , Kamei Hiroyasu , Fukuhara Shigetomo , Yamaguchi Masaaki 
Published: December 2019

ABSTRACT
In order to efficiently derive hematopoietic stem cells (HSCs) from pluripotent precursors, it is crucial to understand how mesodermal cells acquire hematopoietic and endothelial identities: two divergent, but closely related, cell fates. Although Npas4 has been recently identified as a conserved master regulator of hemato-vascular development, the molecular mechanisms underlying cell fate divergence between hematopoietic and vascular endothelial cells are still unclear. Here, we show in zebrafish that mesodermal cell differentiation into hematopoietic and vascular endothelial cells is regulated by Junctional adhesion molecule 3b (Jam3b) via two independent signaling pathways. Mutation of jam3b led to a reduction in npas4l expression in the posterior lateral plate mesoderm and defects in both hematopoietic and vascular development. Mechanistically, we show that Jam3b promotes endothelial specification by regulating npas4l expression through repression of the Rap1a-Erk signaling cascade. Jam3b subsequently promotes hematopoietic development, including HSCs, by regulating lrrc15 expression in endothelial precursors through the activation of an integrin-dependent signaling cascade. Our data provide insight into the divergent mechanisms for instructing hematopoietic or vascular fates from mesodermal cells.
Cored in the act: the use of models to understand core myopathies
Authors: Fusto Aurora , Moyle Louise A. , Gilbert Penney M. , Pegoraro Elena 
Published: December 2019

ABSTRACTThe core myopathies are a group of congenital myopathies with variable clinical expression – ranging from early-onset skeletal-muscle weakness to later-onset disease of variable severity – that are identified by characteristic ‘core-like’ lesions in myofibers and the presence of hypothonia and slowly or rather non-progressive muscle weakness. The genetic causes are diverse; central core disease is most often caused by mutations in ryanodine receptor 1 (RYR1), whereas multi-minicore disease is linked to pathogenic variants of several genes, including selenoprotein N (SELENON), RYR1 and titin (TTN). Understanding the mechanisms that drive core development and muscle weakness remains challenging due to the diversity of the excitation-contraction coupling (ECC) proteins involved and the differential effects of mutations across proteins. Because of this, the use of representative models expressing a mature ECC apparatus is crucial. Animal models have facilitated the identification of disease progression mechanisms for some mutations and have provided evidence to help explain genotype-phenotype correlations. However, many unanswered questions remain about the common and divergent pathological mechanisms that drive disease progression, and these mechanisms need to be understood in order to identify therapeutic targets. Several new transgenic animals have been described recently, expanding the spectrum of core myopathy models, including mice with patient-specific mutations. Furthermore, recent developments in 3D tissue engineering are expected to enable the study of core myopathy disease progression and the effects of potential therapeutic interventions in the context of human cells. In this Review, we summarize the current landscape of core myopathy models, and assess the hurdles and opportunities of future modeling strategies.
Inpatients satisfaction with health care services after emergency admission at teritary hospital of attiki
Authors: Chantzopoulou Maria , Marvaki Christina , Latsou Dimitra , Papageorgiou Dimitris 
Published: December 2019

Introduction: Measuring patients satisfaction is an important process for exploring needs, opinions and suggestions of patients about the healthcare services provided by an organization.Aim: To investigate patients satisfaction with health care services, who urgently admitted to a public hospital. Material and Methods: A simple random sampling was used in the current study. The study period was March - May 2016. The sample consisted of 382 patients. Data was collected by a self-completed questionnaire, which is standardized in Greek population by Polyzos N. et al.Results: According to the results, 69% of patients were very satisfied with the impression about hospital as far as the infrastructure (cleaning, organization and adequacy), medical and hotel equipment, room condition and nutrition. However, it is important that patients were dissatisfied with waiting time for admission to hospital, laboratory tests and operations. Eighty-nine point two percent reported high satisfaction about attention of the staff to the patients and specifically the frequent and understandable communication with the staff and kindness and confidence that they inspired. Generally, the majority of the sample (82.5%) was very satisfied with the hospital services and 95.3% indicated that would use again or recommend the hospital services. Finally, gender, education and duration of hospitalization statistically significantly affect patient satisfaction.Conclusions: These results could be a powerful tool for organizational development and strategic management of health care providers.
Cognitive and functional impairment, and perception of illness in acute stroke patients
Authors: Turana Yuda , Sani Tara , Suryani Eva , Kaptein Adrian 
Published: December 2019

Aim of the studyObjectives
Stroke, the leading cause of death and disability in Indonesia, has a substantial impact on patients’ life. However, only a few studies have assessed the psychological functioning in stroke patients. This study contributes to the need to map out psychological functioning in stroke patients by assessing their illness perception.Subject or material and methodsMethods
This is a cross-sectional, descriptive-analytical study. We used a structured questionnaire which consists of a standardized collection of socio-demographic and clinical characteristics, brain CT-scan results, the severity of neurological deficit using NIH Stroke Scale (NIHSS), cognitive assessment tests, as well as Brief Illness Perception Questionnaire (BIPQ) as an instrument to assess illness perception.ResultsResults
There were 56 stroke patients recruited as participants. The average age was 55.34 + 10.25, with 30.4 % had formal education less than 9-year compulsory education. Cognitive impairment in 64.3% of subjects was associated with lower coherence (p<0.005). Subjects with higher education had higher personal control, treatment control and coherence (p < 0.05). Subjects with mild neurological impairment had lower treatment control and coherence (p < 0.05).DiscussionStroke patients with mild neurologic impairment at discharge had a more positive perception on the timeline, personal and treatment control.ConclusionsStroke patients with mild neurological impairment who had been discharged had a more positive perception on the timeline, personal and treatment control. Cognitive impairment is associated with lower coherence, which underlines the importance of establishing the cognitive baseline before assessing illness perception in stroke patients.
Las arterias de Nueva York. Un nuevo espacio de movilidad. Parkway versus Expressway.
Authors: Duran Fernandez Jose 
Published: December 2019

La Ciudad de Nueva York ha sido un campo de pruebas en la movilidad urbana desde la aparición de la máquina de vapor. En la Ciudad de Nueva York se creó el sistema de transporte de masas en el siglo XIX, el ferrocarril “elevado”, y también se ensayó por primera vez un sistema de transporte individual en el siglo XX, el parkway y su posterior evolución, el expressway. Ambos sistemas conforman el esqueleto de movilidad de la ciudad, y coexisten y se complementan, a pesar de representar dos propuestas de movilidad completamente opuestas. Este artículo profundiza en el origen y la evolución de la movilidad individual en la Ciudad de Nueva York. Desde el parkway creado para escapar de la ciudad, hasta el expressway creado para acceder a ella; espacios de movilidad gemelos y opuestos al mismo tiempo. El artículo es un compendio de nueve textos cortos y un epílogo, que junto a sus respectivos diez documentos gráficos, construyen el corpus de la investigación. El lector pues se enfrenta a un ensayo gráfico formado por pequeños capítulos que le sumergirán en los orígenes y posterior evolución del primer espacio de movilidad individual en la historia de las ciudades. Y esto ocurrió en la Ciudad de Nueva York a lo largo del siglo XX.
Mongersen (GED-0301) for Active Crohn's Disease: Results of a Phase 3 Study
Authors: Sands Bruce E. , Feagan Brian G. , Sandborn William J. , Schreiber Stefan , Peyrin-Biroulet Laurent , Frédéric Colombel Jean , Rossiter Guillermo , Usiskin Keith , Ather Shabana , Zhan Xiaojiang , D'Haens Geert 
Published: December 2019

Introduction:
The objective was to assess the efficacy and safety of GED-0301, an antisense oligodeoxynucleotide to Smad7, in active Crohn's disease (CD).

METHODS:
This phase 3, blinded study randomized patients (1:1:1:1) to placebo or 1 of 3 once-daily oral GED-0301 regimens: 160 mg for 12 weeks followed by 40 mg continuously or alternating placebo with 40 or 160 mg every 4 weeks through week 52.

RESULTS:
In all, 701 patients were randomized and received study medication before premature study termination; 78.6% (551/701) completed week 12, and 5.8% (41/701) completed week 52. The primary endpoint, clinical remission achievement (CD Activity Index score <150) at week 12, was attained in 22.8% of patients on GED-0301 vs 25% on placebo (P = 0.6210). At study termination, proportions of patients achieving clinical remission at week 52 were similar among individual GED-0301 groups and placebo. More placebo vs GED-0301 patients achieved endoscopic response (>50% decrease from baseline Simple Score for CD) at week 12 (18.1% vs 10.1%). Additional endoscopic endpoints were similar between groups at weeks 12 and 52. More placebo vs GED-0301 patients had clinical response (≥100-point decrease in the CD Activity Index score) at week 12 (44.4% vs 33.3%); at week 52, clinical response rates were similar. Adverse events were predominantly gastrointestinal and related to active CD, consistent with lack of clinical and endoscopic response to treatment. Two deaths occurred (GED-0301 total group) due to small intestinal obstruction and pneumonia; neither was suspected by the investigator to be treatment-related.

DISCUSSION:
GED-0301 did not demonstrate efficacy vs placebo in active CD.
Lessons Learned through Research Partnership and Capacity Enhancement in Inuit Nunangat
Authors: Carter Natalie Ann , Dawson Jackie , Simonee Natasha , Tagalik Shirley , Ljubicic Gita 
Published: December 2019

Facilitating research and enhancing community research capacity through a partnered approach in Inuit Nunangat (the Inuit homeland of Canada, located in Arctic Canada) presents learning opportunities and challenges for southern-based, non-Inuit researchers and community members alike. This article outlines lessons learned through the Arctic Corridors and Northern Voices (AC-NV) project, which involved 14 communities across Inuit Nunangat. The AC-NV focused on understanding community-identified impacts and potential management options of increased shipping in Inuit Nunangat due to sea ice reductions and a changing climate. The approach used to conduct the research involved visiting researchers and community partners working together with local organizations, and training and hiring northern youth as cultural liaisons and workshop co-facilitators. We strove to develop a model of collaborative partnership and strong north-south research relationships. In this paper, we draw on our broad learning experiences from four community case studies conducted as part of the AC-NV project: Arviat, Cambridge Bay, Gjoa Haven, and Pond Inlet, Nunavut. Close partnerships were formed in each of these communities, and 32 youth were trained in participatory mapping and workshop facilitation. For our diverse team of Inuit, northern- (i.e., non-Inuit, living in Inuit Nunangat), and southern-based non-Inuit researchers, our efforts to engage in partnered research were a critical component of the research and learning experience. In this article we share methodological reflections and lessons learned from what collaborative-partnered research means in practice. In so doing, we aim to contribute to the increasing dialogue and efforts around knowledge co-production and Inuit self-determination in research. Key conclusions of this reflective exercise include the importance of 1) conducting research that is relevant to local needs and interests, 2) visiting researchers and local organizations partnering together, 3) co-creating and refining knowledge documentation tools, 4) including youth cultural liaisons as co-facilitators, 5) conducting results validation and sharing exercises, and 6) being open to forming personal friendships. For the AC-NV, this community-based partnership approach resulted in more robust research results, strengthened north-south relations, and enhanced local capacity for community-led projects.
Too Much Stick for the Carrot? Job Search Requirements and Search Behaviour of Unemployment Benefit Claimants
Authors: Morescalchi Andrea , Paruolo Paolo 
Published: December 2019

Abstract
This paper investigates the effects of stricter job search-related conditions for Unemployment Insurance (UI) eligibility on the job search behaviour of claimants. Estimation makes use of exogenous variation introduced by the UK Jobseeker’s Allowance. A significant share of claimants is found to leave the register increasing search intensity as well as request for job search assistance from Public Employment Centres. Exits with increased search are performed predominantly by liquidity constrained individuals. This evidence suggests that tighter search conditionality can lead committed jobseekers to un-subsidized search, reducing the capacity of UI to protect workers against the risk of unemployment.
Assessing Higher Education Policy in Brazil: A Mixed Oligopoly Approach
Authors: Del Rey Elena , Estevan Fernanda 
Published: December 2019

Abstract
Higher education is increasingly provided by both public and private universities, in particular in the developing world. Considering a mixed oligopoly setting and inspired by the Brazilian context, we explore the relative merits of some frequently used higher education policies in a context where a high-quality public university interacts with a lower-quality private university. We calibrate the model to match relevant values of Brazilian earnings and educational distribution. Subsidising private university tuition fees increases participation, but many high ability students remain excluded, especially if the subsidy is substantial. Affirmative action improves the surplus associated with the public university system, as more high ability individuals attend the public university, but virtually does not increase higher education participation. Although an expansion of public university places induces a reduction in private university fees, total university enrolment grows slowly, and many high-ability individuals cannot obtain a university education.
Utilizing Maximum Entropy Spectral Analysis (MESA) to identify Milankovitch cycles in Lower Member of Miocene Zhujiang Formation in north slope of Baiyun Sag, Pearl River Mouth Basin, South China Sea
Authors: Yuan Rui , Zhu Rui , Xie Shiwen , Hu Wei , Zhou Fengjuan , Yu Ye 
Published: December 2019

Abstract
Logs in the petroleum boreholes indirectly records the sedimentary cycles in the deep burial formation. In order to extract and understand the periodicity and cyclicity, it is necessary to process the data by digital signal analysis method. Taking the gamma ray (GR) log as the primary material, an identification approach of Milankovitch cycles in boreholes is proposed in this paper, which is based on the Maximum Entropy Spectral Analysis (MESA). The first stage chooses the appropriate windows for calculating the frequency spectral properties in a short section of the data. In each depth window, the second stage generates the two-dimension frequency spectrum utilizing the MESA. At each depth point, the third stage finds the potential Milankovitch cycles in the one-dimension frequency spectrum, in which the average amplitude spectrum peak would be matched to the ratio of Milankovitch period. According to the frequency and wavelength of the maximum amplitude in Milankovitch cycles, the fourth stage estimates the sedimentation rate controlled by cyclical factor. Finally, the Milankovitch cycles in Lower Member of Miocene Zhujiang Formation in north slope of Baiyun Sag, Pearl River Mouth Basin, are identified and the cyclical sedimentation rate is estimated. The results demonstrate that the proposed method is feasible and effective to identify Milankovitch cycles in boreholes, which may contribute to the other geological researches.
Predictive factors of intestinal necrosis in acute mesenteric ischemia
Authors: Canfora Alfonso , Ferronetti Antonio , Marte Gianpaolo , Maio Vittorio Di , Mauriello Claudio , Maida Pietro , Bottino Vincenzo , Aprea Giovanni , Amato Bruno 
Published: December 2019

Abstract

Objectives
Acute mesenteric ischemia (AMI) is a gastrointestinal and vascular emergency in which the detection of patients requiring intestinal resection is mandatory.

Methods
Registered data of 55 consecutive patients admitted to our center between January 2010 and December 2016 that underwent an explorative laparotomy for a suspected diagnosis of irreversible transmural intestinal necrosis (ITIN) were analyzed. Demographic, clinical, laboratory and CT findings were statistically analyzed in order to search predictive factors of ITIN and their correlation to its clinical spectre.

Results
Tobacco use was the most statistically significant (p<0.01) cardiovascular disease risk factor involved in ITIN. Among lab tests, Serum lactate levels ˃ 2mmol/L resulted in a statistically significant association with ITIN (p=0.0001). Organ failure (defined as Marshall score> 2) and the three main CT findings (decreased bowel wall enhancement, bowel loop dilation and demonstrated vessel occlusion) were strongly associated with ITIN (p values: 0.001, 0.007, 0.0013, 0.0005). Only serum lactate levels>2 mmol/L resulted as statistically significant as predictive factors of ITIN in multivariate analysis using logistic regression (OR 49.66 and p-value 0.0021).

Conclusion
Our univariate and multivariate analysis identified multiple factors (Serum lactate levels ˃ 2mmol/L, Organ failure, CT signs) that could suggest patients that require a surgical approach for ITIN.
Resuscitation following a bupivacaine injection for a cervical paravertebral block
Authors: Vosylius Saulius , Uvarovas Valentinas , Svediene Saulė , Satkauskas Igoris 
Published: December 2019

Abstract

Background
Cardiac arrest related to nerve blockade using a local anaesthetic is a rare event. We report a case of bupivacaine severe cardiovascular toxicity following cervical paravertebral nerve block.

Case presentation
A 44-year-old female was admitted to Republican Vilnius University Hospital, with symptoms of sustained severe pain in her neck that radiated to both arms. Multiple cervical intervertebral hernias with spinal stenosis were confirmed by magnetic resonance imaging. Following infiltration of the subcutaneous tissue with a 0.5 % bupivacaine solution, an 18-gauge spinal needle was used to perform the paravertebral block at the C6 level. Bupivacaine was injected in incremental doses to a total of 10 mL. Rapid loss of consciousness and cardiovascular collapse suggested a neuraxial injection of bupivacaine. Long-lasting cardiopulmonary resuscitation, including chest compressions, defibrillation attempts for refractory ventricular fibrillation, medications, mechanical ventilation, and intravenous lipid emulsion infusion, was successful. No severe adverse outcomes other than acute kidney injury and chest pain related to prolonged chest compressions were documented.

Conclusions
This case report emphasizes the necessity of ensuring adequate safety precautions to avoid local anaesthetic systemic toxicity. Lipid emulsion preparations should be available in all hospital settings where local anaesthetics are used for regional anaesthesia or pain management.