bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Three-Gap Model of Health Worker Performance
Authors: Ibnat Fabliha , Leonard Kenneth , Bawo Luke , Mohammed-Roberts Rianna 
Published: February 2020

Abstract
Background: Improving process quality remains a signiﬁcant opportunity to improve outcomes in many low resource settings, however a continued focus on improving knowledge through increased training has proven ineﬀective. In this context, we introduce a methodology for diagnosing the causes of low quality care, including not only low knowledge, but also infrastructure and material as well as motivation.Methods: The Three-Gap Model uses four measures of performance — target performance, actual performance, the capacity to perform and the knowledge to perform — to deﬁne three gaps for each health worker: the gap between target performance and what they have the knowledge to do (the know gap); the gap between their knowledge and their capacity to perform (the know-can gap) and the gap between their capacity and what they actually do (the can-do gap).Results: Using data on pediatric care from hospitals in Liberia, we illustrate how the model can be used to investigate the potential for improvements in the quality of care from several possible policy interventionsConclusions: The analysis of the relationships between these gaps across health workers in a health system help to paint a better picture of the determinants of performance and can assist policymakers in choosing relevant policies to improve health worker performance.
Challenge for Diagnostic Assessment of Deep Learning Algorithm for Metastases Classification in Sentinel Lymph Nodes on Frozen Tissue Section Digital Slides in Women with Breast Cancer
Authors: Kim Young-Gon , Song In Hye , Lee Hyunna , Yang Dong Hyun , Kim Namkug , Shin Dongho , Yoo Yeonsoo , Lee Kyowoon , Kim Dahye , Jung Hwejin , Cho Hyunbin , Lee Hyungyu , Kim Taeu , Choi Jong Hyun , Seo Changwon , Han Seong il , Lee Young Je , Lee Young Seo , Yoo Hyung-Ryun , Lee Yongju , Park Jeong Hwan , Gong Gyungyub , Oh Sohee 
Published: February 2020

Abstract
Assessing the status of metastasis in sentinel lymph nodes (SLNs) by pathologists is an essential task for the accurate staging of breast cancer. However, histopathological evaluation of sentinel lymph nodes by a pathologist is not easy and is a tedious and time-consuming task. The purpose of this study is to review a challenge competition (HeLP 2018) to develop automated solutions for the classification of metastases in hematoxylin and eosin–stained frozen tissue sections of SLNs in breast cancer patients. A total of 297 digital slides were obtained from frozen SLN sections, which include post–neoadjuvant cases (n = 144, 48.5%) in Asan Medical Center, South Korea. The slides were divided into training, development, and validation sets. All of the imaging datasets have been manually segmented by expert pathologists. A total of 10 participants were allowed to use the Kakao challenge platform for six weeks with two P40 GPUs. The algorithms were assessed in terms of the AUC (area under receiver operating characteristic curve). The top three teams showed 0.986, 0.985, and 0.945 AUCs for the development set and 0.805, 0.776, and 0.765 AUCs for the validation set. Micrometastatic tumors, neoadjuvant systemic therapy, invasive lobular carcinoma, and histologic grade 3 were associated with lower diagnostic accuracy. In a challenge competition, accurate deep learning algorithms have been developed, which can be helpful in making frozen diagnosis of intraoperative sentinel lymph node biopsy. Whether this approach has clinical utility will require evaluation in a clinical setting.
Prevalence and Risk Factors for Anxiety and Depression in Chinese Unruptured Intracranial Aneurysms Patients Treated by Endovascular Intervention
Authors: Zhai Xiao-Dong , Yu Jia-Xing , Ma Yong-Jie , Li Gui-Lin , He Chuan , Hu Peng , Xiang Si-Shi , Wang Jun , Zhang Hong-Qi 
Published: February 2020

Abstract
Background: Studies on anxiety and depression after treatment via endovascular intervention for unruptured intracranial aneurysm (UIA) patients are rare and controversial. We aimed to explore the prevalence of anxiety and depression among Chinese UIA patients treated by endovascular intervention and to identify which factors contribute to the development of these symptoms.Methods: We performed a cross-sectional study of anxiety and depression in patients who underwent endovascular treatment for UIAs using the Hospital Anxiety and Depression Scale (HADS). The demographic, clinical and radiological data for all patients were retrospectively collected from the aneurysm database and medical records. Moreover, we utilized a large sample data and logistic regression analysis to investigate the risk factors for the anxiety and depression for these patients. Results: Two hundred patients returned a completed questionnaire in this study. Of the 200 patients, 34 (17.0%) suffered from anxiety, and 31 (15.5%) suffered from depression after being discharged for 30.67±8.6 months. The multivariate analysis results indicated that treatment cost exceeding the annual household income was statistically significantly associated with anxiety (OR= 2.42, p= 0.03). Patients with shorter sleep time was statistically significantly associated with anxiety (OR= 1.51, p= 0.02) and depression (OR= 1.62, p= 0.007).Conclusion: The prevalence of anxiety and depression in the UIA patients treated by endovascular intervention was 17.0% and 15.5% respectively. Treatment cost exceeding the annual household income was statistically significantly associated with anxiety. Patients with shorter sleep time was statistically significantly associated with anxiety and depression. Our findings provide valuable evidence for the clinical and psychological management of these patients.
On the synonymy of Trophotylenchulus asoensis and T. okamotoi with T. arenarius, and intra-generic structure of Paratylenchus (Nematoda: Tylenchulidae)
Authors: Mirbabaei Hossein , Eskandari Ali , Ghaderi Reza , Karegar Akbar 
Published: February 2020

Abstract
Two populations of the genus Trophotylenchulus and 10 species of the genus Paratylenchus from Iran were characterized based on morphometric, morphological and molecular characters. Our observations on the two populations of Trophotylenchulus from Iran revealed that T. asoensis and T. okamotoi have been distinguished from T. arenarius, on the basis of the features which cannot be longer considered as stable diagnostic characters. One of the populations shows a mixed combination of the characters of T. arenarius and T. asoensis; it has morphometrics more similar to T. arenarius but shows affinities with T. asoensis in the tail terminus shape of females and second-stage juveniles (J2) and in having a reduced stylet in males. The other population fit well with T. okamotoi; it has females with generally bluntly rounded tails typical for T. okamotoi, but sometimes with finely rounded tail termini, like those of T. arenarius or T. asoensis. The sequences of D2–D3 expansion segments of 28 S rRNA gene for the two populations are identical with each other, but only 4 bp (0.67%) difference with T. arenarius sequence deposited in the GenBank. Considering no stable difference allow separating species, synonymy of T. asoensis and T. okamotoi with T. arenarius, which has already been proposed, is supported and confirmed here. All studied Paratylenchus species with stylets longer than 40 µm, except P. straeleni, formed a basal cluster to Cacopaurus pestis and species of Paratylenchus bearing stylets shorter than 40 µm; thus, validity of Gracilacus cannot be rejected using our data sets. However, the synonymy of Paratylenchoides was supported by the positioning of P. sheri within representatives of Paratylenchus in the inferred phylogenetic tree.
Reproduction and life history traits of a resistance breaking Globodera pallida population
Authors: Mwangi James M. , Niere Björn , Finckh Maria R. , Krüssel Stefan , Kiewnick Sebastian 
Published: February 2020

Abstract
The main and most efficient measure to control potato cyst nematode (PCN) is the use of resistant cultivars. German and Dutch National Plant Protection Organizations (NPPOs) recently reported the emergence of Globodera pallida populations virulent on potato cultivars carrying resistance against pathotype 2/3. The development and virulence of the virulent population Oberlangen from Germany in comparison to the reference population G. pallida Pa3 Chavornay were investigated on resistant and susceptible cultivars in glasshouse experiments. Various life history traits associated with change in virulence were also assessed. Hatching of second-stage juveniles (J2s) was similar for both populations but incubation of cysts in potato root diffusate resulted in higher hatching rates compared to 3 mM Zinc Chloride and tap water. Both populations showed high penetration rates in the roots of the resistant and susceptible cultivars. However, only the population Oberlangen was able to complete the life cycle in the roots of the resistant potato cultivar. In ‘Seresta’, the resistance response restricted the formation of females by avirulent individuals in favor of males. Oberlangen was virulent on all cultivars tested. No difference in cyst size, number of eggs per cyst, length of juveniles, and males was found for Oberlangen and Chavornay on the susceptible cv. ‘Desiree’. However, cysts of virulent populations from the same region Oberlangen was obtained from had a significantly larger diameter compared to avirulent populations. The population Oberlangen showed a higher reproduction and fitness than the reference population Chavornay on susceptible cultivars and could serve as a future reference population in testing of new potato cultivars for resistance against this new virulence type in Europe.
Reinventing Place-identity and Embracing New Economic Opportunities: Promoting Creative Economy of Sanur Through Public Participation
Authors: Gede Maha Putra Nyoman , Parama Putra Ida Bagus Gede 
Published: February 2020

Every place on the planet has unique characters that make it distinguishable from other sites. Place-identity is the term widely accepted to explain this phenomenon. It is argued that the place-identity could not only strengthen the sense of belonging of the locals to a place and improve social cohesion but, in the age of global tourism, it could also increase the attractiveness of the place to visitors. Therefore, it contains economic values if managed in a proper way. But places are transforming. The dynamics of contemporary activities where tradition is seen as outdated, new government system, new economic activities, and new actors and their roles challenge the stability of place-identity. Unfortunately, the transformation of a place may benefit some actors but may trouble other groups. Some places, however, maintain their place-identity for the social and economic values it holds. Collaboration among different actors in managing the transformation of such place could maintain the place-identity of a place which ensures its attractiveness to visitors, sustains its economic values amidst rapid changes. The collaboration confirms no one is left behind. The case study research conducted in Sanur showed that the sustained place-identity could economically benefit all actors.
An autonomous operational trajectory searching system for an economic and environmental membrane bioreactor plant using deep reinforcement learning
Authors: Nam KiJeon , Heo SungKu , Loy-Benitez Jorge , Ifaei Pouya , Yoo ChangKyoo 
Published: February 2020

Abstract
Optimal operation of membrane bioreactor (MBR) plants is crucial to save operational costs while satisfying legal effluent discharge requirements. The aeration process of MBR plants tends to use excessive energy for supplying air to micro-organisms. In the present study, a novel optimal aeration system is proposed for dynamic and robust optimization. Accordingly, a deep reinforcement learning (DRL)-based optimal operating system is proposed, so as to meet stringent discharge qualities while maximizing the system's energy efficiency. Additionally, it is compared with the manual system and conventional reinforcement learning (RL)-based systems. A deep Q-network (DQN) algorithm automatically learns how to operate the plant efficiently by finding an optimal trajectory to reduce the aeration energy without degrading the treated water quality. A full-scale MBR plant with the DQN-based autonomous aeration system can decrease the MBR's aeration energy consumption by 34% compared to other aeration systems while maintaining the treatment efficiency within effluent discharge limits.
Review of MiRNA-Disease Association Prediction
Authors: Jiang Lei , Zhu Ji 
Published: February 2020

:
Accumulating evidence demonstrates that miRNAs serve as critical biomarkers in various
complex human diseases. Thus, identifying potential miRNA-disease associations has become a hot
research topic for providing a better understanding of disease pathology, including cell carcinoma, cell
proliferation and mevalonate pathway. Recently, based on various biological datasets, more and more
computational prediction methods have been designed to uncover disease-related miRNAs for further
experimental validation. Due to the fact that different limitations exist in previous computational
methods, we proposed the model of Decision Template-based MiRNA-Disease Association prediction
(DTMDA) to prioritize potential related miRNAs for diseases of interest. By integrating miRNA functional
similarity network, miRNA Gaussian interaction profile kernel similarity network, two disease
semantic similarity networks and disease Gaussian interaction profile kernel similarity network, we
trained five multi-label K nearest neighbors-based core classifiers.
Determination of Fundamental Medication Reconciliation Features with an International Perspective
Authors: Tafazoli Ali 
Published: February 2020

Background:
Medication reconciliation is a major part of clinical care transitions that
can promote patient safety and satisfaction. The main administrators of this process are pharmacy
practitioners. Currently, many medical centers all over the world implement the procedures of
medication reconciliation with varying styles and inconsistent success. Some other centers are going
to build protocols in the near future. By now, there is no consensus for an optimal method of
running medication reconciliation and each center has its own approach. This fact can cause a huge
amount of resource wastages. In this narrative review, we searched scientific literature in this field
in order to extract, underline and formalize the specific features which help a medical center to
reach an optimized medication reconciliation plan.

Methods:
We explored the PubMed database with keywords of “medication reconciliation” and
“pharmacy service” to obtain a relevant reference pool for our topic. Then we checked the affiliations
of authors to be assured of the international diversity of our perspective.

Results:
Our search method yielded 184 journal articles from different continents. The frequency of
published articles from America was higher and then, Europe, Australia, Asia and Africa were
placed, respectively.

Conclusion:
According to the results, inclusion of factors like establishing phases for implementation,
proper education, developing academic coordination, providing suitable facilities, specialization
of the services, periodical evaluations and promoting pharmacy practice in the development of
medication reconciliation will potentially lead to an optimized plan.
Internalisasi nilai pendidikan kewarganegaraan pada tradisi pesta laut blanakan dalam rangka pengembangan ideal democratic citizen
Authors: Halimah Lili , Anisah Anisah 
Published: February 2020

Pendidikan memiliki peranan yang penting dalam kehidupan manusia, dan diharapkan dapat menciptakan manusia yang berkualitas. Pendidikan Kewarganegaraan memiliki tiga kompetensi yang dapat membentuk “the ideal democratic citizen” yakni kompetensi civic knowledge, civic skills, dan civic disposition. Pembelajaran PPKn mengaitkan antara teori dengan praktek nyata di lapangan, dan berhubungan dengan nilai-nilai budaya yang beragam dan majemuk. Faktor yang mempengaruhi nilai budaya lokal dalam melestarikan kebudayaan melalui upacara adat pesta laut Blanakan Kabupaten Subang Jawa Barat yang dilakukan setahun sekali guna menghormati leluhurmya. Penelitian ini menggunakan pendekatan kualitatif. Hasil penelitian (a) Masyarakat nelayan memunculkan civic knowledge yang diarahkan oleh para tokoh, sehingga memiliki kesadaran untuk melestarikan nilai-nilai kebudayaan, yang mampu mengeksplorasi dan memanfaatkan potensi alam daerah, (b) Nilai-nilai dalam pesta laut, selalu memerlukan civic skill yang cakap dalam mengorganisasikan kegiatan, semua ini diperlukan partipatory skill, dan (c) Membentuk karakter masyarakat nelayan pada pesta laut, dengan cara memberi tahu dan mengajarkan hal-hal yang baik oleh para tokoh budaya. Dengan demikian perlu ditanamkan the ideal democratic citizen untuk meningkatkan kecintaan pada nilai budaya lokal, dan tidak terpengaruh oleh budaya asing.----------------------------------------------------------- Internalization the value of citizenship education in the traditional sea party tradition (Pesta Laut Blanakan) in order to develop the ideal democratic citizenEducation has an important role in human life and is expected to create quality human beings. Citizenship Education has three competencies that can form the ideal democratic citizen, namely civic knowledge, civic skills, and civic disposition competencies. PPKn learning links theory with real practice in the field, and deals with diverse and pluralistic cultural values. Factors that influence the value of local culture in preserving culture through the Blanakan Subang regency West Java regency traditional ceremony which is conducted annually to honor its ancestors. This study uses a qualitative approach. Research results (a) The fishing community raises civic knowledge directed by leaders, so that they have an awareness to preserve cultural values, which are able to explore and utilize the natural potential of the region, (b) Values in sea party, it always requires civic skills that competent in organizing activities, all of this requires participatory skills, and (c) forming the character of fishing communities at sea party, by telling and teaching good things by cultural leaders. Thus it is necessary to instill the ideal democratic citizen to increase the love of local cultural values, and not be influenced by foreign cultures.
Online Health Information–Seeking Among Older Women With Chronic Illness: Analysis of the Women’s Health Initiative
Authors: Sedrak Mina S , Soto-Perez-De-Celis Enrique , Nelson Rebecca A , Liu Jennifer , Waring Molly E , Lane Dorothy S , Paskett Electra D , Chlebowski Rowan T 
Published: February 2020

Background
Understanding how older patients with chronic illnesses use the internet to obtain health information is relevant for the design of digital interventions aimed at improving the health and well-being of adults aged 65 years and older; this cohort represents the sickest, most expensive, and fastest-growing segment of the US population.

Objective
The objective of our study was to describe online health information–seeking behavior among older patients with chronic illnesses and to compare the characteristics of patients who report using the internet to obtain health information with those who do not.

Methods
The study population included 72,806 women aged 65 years and older enrolled in the Women’s Health Initiative (WHI), a national cohort study, who completed a 2014 supplemental questionnaire assessing everyday technology use and internet use for researching health conditions. Comparisons were made between participants with and without a history of chronic illness and between users and nonusers of online sources for health information. Multivariate logistic regression was used to estimate odds ratios (ORs) and 95% CIs.

Results
Of the total, 59% (42,887/72,806) of older women used the internet for health information. Compared with women who did not use the internet to obtain health information, those who used the internet were younger (median age: 76 vs 81 years), more likely to be non-Hispanic white (90% [38,481/42,887] vs 87% [26,017/29,919]), earned a higher income (over $US 50,000: 55% [23,410/42,887] vs 33% [9991/29,919]), achieved a higher educational level (more than high school: 87% [37,493/42,887] vs 75% [22,377/29,919]), and were more likely to live with a partner (52% [22,457/42,887] vs 36% [10,759/29,919]) (all P<.001). Women with Alzheimer disease were least likely to report online health information–seeking compared to those without the disease (OR 0.41, 95% CI 0.38-0.43). In contrast, women with a recent diagnosis of cancer, within the previous 2 years (OR 1.23, 95% CI 1.11-1.36) or 2-5 years ago (OR 1.09, 95% CI 1.00-1.19), were most likely to use the internet for health information.

Conclusions
Nearly 6 in 10 older women participating in the WHI reported using the internet to obtain health information. Patients recently diagnosed with cancer are more likely to be looking for health information online, even after adjustment for age, suggesting that these patients may have a greater need for digital health resources.
A RELATIONSHIP BETWEEN PROBLEM SOLVING ABILITY AND STUDENTS’ MATHEMATICAL THINKING
Authors: Delima Nita 
Published: February 2020

This research have a purpose to know is there an influence of problem solving abilty to students mathematical thinking, and to know how strong problem solving ability affect students mathematical thinking. This research used descriptive quantitative method, which a population is all of students that taking discrete mathematics courses both in department of Information Systems and department of mathematics education. Based on the results of data analysis showed that there are an influence of problem solving ability to students mathematical thinking either at department of mathematics education or at department of information systems. In this study, it was found that the influence of problem solving ability to students mathematical thinking which take place at mathematics education department is stonger than at information system department. This is because, at mathematics education department, problem-solving activities more often performed in courses than at department of information system. Almost 75% of existing courses in department of mathematics education involve problem solving to the objective of courses, meanwhile, in the department of information systems, there are only 10% of these courses. As a result, mathematics education department student’s are better trained in problem solving than information system department students. So, to improve students’ mathematical thinking, its would be better, at fisrtly enhance the problem solving ability.