bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of the UHRF1BP1 gene with systemic lupus erythematosus was replicated in a Han Chinese population from mainland China
Authors: Wen Leilei , Liu Lu , Shen Xue , Li Hui , Zhu Zhengwei , Huang He , Cai Minglong , Qian Danfeng , Shen Songke , Qiu Ying , Cui Yong , Sheng Yujun 
Published: November 2019

AbstractSingle‐nucleotide polymorphisms (SNPs) in the UHRF gene have been shown to be associated with systemic lupus erythematosus (SLE) in European and Hong Kong Chinese, but statistically significant evidence for association has not been found in a mainland Han Chinese population. Therefore, we selected SNP rs13205210 located in UHRF1BP1 as a candidate association from our previously published genome‐wide association study (GWAS) data of SLE (1,047 cases and 1,205 controls from a mainland Han Chinese population) to explore the association between the UHRF1BP1 gene and SLE. We conducted a large‐scale replication study in an additional independent sample of 3,509 cases and 8,246 controls from a mainland Han Chinese population. Real‐time PCR was used to determine gene expression differences in peripheral blood mononuclear cells (PBMCs) from cases and controls. As a result, we replicated the association between the UHRF1BP1 gene and SLE (rs13205210, missense, Pmeta = 2.26E‐17, odds ratio = 1.41) by a meta‐analysis of our previous GWAS and this replication study involving a total of 4,556 cases and 9,451 controls. The UHRF1BP1 mRNA expression level in PBMCs was significantly decreased in patients with SLE compared with that in healthy controls. SNP rs13205210 exhibited an expression quantitative trait loci effect on the UHRF1BP1 gene in PBMCs from patients. In conclusion, this study not only suggests that the UHRF1BP1 gene was associated with SLE in a mainland Han Chinese population, but also implied that it might be a common genetic factor contributing to SLE susceptibility in multiple populations.
Association of Craving and Depressive Symptoms in Ketamine‐Dependent Patients Undergoing Withdrawal Treatment
Authors: Chen Lian‐Yu , Chen Chih‐Ken , Chen Chun‐Hsin , Chang Hu‐Ming , Huang Ming‐Chyi , Xu Ke 
Published: November 2019

Background and ObjectivesKetamine has emerged as one of the major illicit substances worldwide. Craving, a primary symptom for addiction, is a key challenge for ketamine abusers attempting abstinence. A link between craving and negative affect has been suggested previously for other substances. We examined the relationship between craving and negative effect (depression and anxiety) in patients with ketamine dependence (KD) undergoing withdrawal treatment.MethodsWe included 104 patients with KD (76 males and 28 females) who received inpatient treatment for ketamine withdrawal and assessed them by using Beck Depression Inventory (BDI), Beck Anxiety Inventory, and a visual analog scale (VAS; 0‐100 mm) for ketamine craving on day 2 to 3 of admission.ResultsFifty‐nine (59%) and 38 (38.7%) of our patients reported moderate‐to‐severe depression and anxiety symptoms, respectively. Patients with greater cravings (ie, greater than the median VAS) reported spending more days on ketamine in the preceding month and displayed severer depressive symptoms than did those with lower cravings. VAS was significantly correlated with BDI scores after adjustment. Patients who stayed in the treatment longer (more than 2 weeks) experienced more cravings and depressive symptoms than those who did not.Discussion and ConclusionsWe observed a high prevalence of depression in patients with KD, particularly those with higher cravings. Patients with greater cravings and severer depression might require a longer duration of withdrawal treatment.Scientific SignificanceThis research provides intimal evidence for an association between depression and craving in patients with KD. Screening and management of depression are recommended for this population. (Am J Addict 2019;00:00–00)
The Volunteer Dementia and Delirium Care (VDDC)© program: An exploration of perceived barriers and enablers to implementation in an acute and subacute metropolitan hospital
Authors: Ayton Darshini , Moran Chris , Berkovic Danielle , Bateman Catherine , Anderson Katrina , Blair Annaliese , Soh Sze‐Ee , Morello Renata , Ying Lim Yen , Liew Danny 
Published: November 2019

AbstractObjectiveTo explore the perceived barriers and enablers to the implementation of the Volunteer Dementia and Delirium© program from the perspective of key stakeholders in a metropolitan hospital network.MethodsFocus groups and interviews with hospital staff, volunteers, patients and caregivers. Deductive analysis was conducted for the Behaviour Change Wheel (COM‐B) domains, and inductive thematic analysis for emerging themes.ResultsUtilising the skills and knowledge of volunteers, making the program available to all patients, and recognising that volunteers will improve the care experience for patients were identified as enablers. Threats to volunteer safety, difficulty in defining roles and responsibilities of volunteers, volunteer attrition and availability and supervision of volunteers were perceived as barriers to implementation.ConclusionTo enhance the implementation of the program into a metropolitan setting, strategies addressing the identified barriers and enablers need to be developed.
What are the policy and program implications of individual budget style service models for low‐income older renters?
Authors: Cornell Victoria 
Published: November 2019

AbstractObjectiveTo explore the policy and program implications of the Australian aged care reforms for low‐income older renters.MethodsInterviews and focus groups with low‐income older renters and service providers of both housing and in‐home aged care were undertaken.ResultAnalysis of the findings emphasised the complex world of aged care service provision, particularly for low‐income renters and their service providers.ConclusionsSocietal, systemic and systematic change is required to ensure easier access to services. Policy and programming must be driven from both the bottom up and the top down, and not take a “market‐making by government” approach.
Hematological toxicities associated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Authors: Wong Evelyn Y. T. , Tan Grace H. C. , Kumar Mrinal , Teo Melissa C. C. 
Published: November 2019

AbstractIntroductionCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been found to prolong survival in selected patients with peritoneal disease, but the extent of cytoreduction and chemoperfusion can result in systemic toxicities. We evaluate the incidence of perioperative hematological complications and its associated risk factors.MethodsRetrospective analysis of a prospectively collected database of CRS‐HIPEC cases between April 2001 and October 2016 was performed. Patients were stratified based on the clinicopathological characteristics, perioperative incidence, grade, and duration of leukopenia (white blood cells < 4000/mm3), neutropenia (absolute neutrophils < 2000/mm3), and thrombocytopenia (platelets < 140 000/mm3).ResultsTwo hundred and thirty‐five CRS‐HIPEC were performed in 220 patients with peritoneal metastasis of colorectal, ovarian, primary peritoneal, appendiceal, or mesothelioma origins. The incidences of leukopenia, neutropenia, and thrombocytopenia were 15.3%, 3.8%, and 37.9%, respectively. Median time to onset was 1 day (0‐16 days), 0 day (0‐2 days), and 1 day (1‐2 days), respectively, after operation. Median duration of leukopenia, neutropenia, and thrombocytopenia was 1 day (1‐3 days), 1 day (1‐2days), and 3 days (range 0‐16 days), respectively. Age > 60 (odds ratio [OR] 0.229 [95% CI: 0.105‐0.502], P < .001) and the use of prior chemotherapy (OR 2.46 [95% CI: 1.24, 4.83], P = .010) were independent risk factors for thrombocytopenia on multivariable logistic regression.ConclusionHematological toxicities are common after hyperthermic intraperitoneal chemotherapy with thrombocytopenia being most common. Patients with age > 60, and who have undergone chemotherapy, are at risk of these toxicities and should be closely monitored post CRS‐HIPEC.
Hackerspace Network: Prefiguring Technopolitical Futures?
Authors: R. Murillo Luis Felipe 
Published: November 2019

ABSTRACTUnder the practical symbol of “hacking,” computer expertise has been translated into renewed forms of political action in the past two decades. In this article, I examine this phenomenon through the study of self‐organized collectives for technoscientific experts who identify as “hackers.” Based on multisited field research in global cities of the Pacific Rim, I describe the formation of a network of community spaces called “hackerspaces” with a focus on their exchange practices and transnational ties. The alternative globalization of hacking through these convivial spaces for socialization and self‐training has created new political locations and horizons, shifting the moral valence of hacking toward more open and collaborative practices. The hackerspace network is one of the key sites for the observation of this transformation for prefiguring new technical and political practices, hence its relevance for anthropological studies of technology and politics in the contemporary moment. [computing, expertise, hacking, technopolitics, hackerspaces]
An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men
Authors: Esteves Sandro C. , Santi Daniele , Simoni Manuela 
Published: November 2019

AbstractBackgroundSperm chromatin integrity is essential for normal embryo development and pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to measure the proportion of spermatozoa with damaged chromatin in the ejaculate. SDF is associated with potentially treatable conditions, including varicocele, male accessory gland infections, inadequate lifestyle, and gonadotoxin exposure, thus prompting their treatment as a means of improving sperm DNA quality and the reproductive outcomes.ObjectiveTo provide an up‐to‐date review of the role of clinical and surgical interventions on SDF values in subfertile men.Materials and methodsAn extensive search of studies examining the relationship between male infertility conditions associated with SDF was performed using PubMed and MEDLINE, with a focus on interventional therapy. The start date for the search was not defined, whereas the end date was March 2019. Randomized and non‐randomized controlled trials, observational studies, systematic and narrative reviews, and case series were evaluated.ResultsTreating the underlying male infertility factor seems a promising way to alleviate SDF and to increase the likelihood of achieving natural and assisted conception, but data remain limited. The best evidence relates to varicocele repair and hormonal therapy with the follicle‐stimulating hormone. Antioxidant therapy and lifestyle changes might alleviate oxidative sperm markers and decrease SDF but their effects on pregnancy outcomes are still unclear. Among men with high SDF undergoing assisted reproductive technology, the use of testicular spermatozoa in preference over ejaculated spermatozoa for intracytoplasmic sperm injection (ICSI) has been shown to improve pregnancy rates possibly owing to the better sperm chromatin quality in testicular spermatozoa than in ejaculated spermatozoa.ConclusionCurrent evidence supports interventional therapy as a means to alleviate sperm DNA damage. Identification of the conditions associated with SDF remains important to enable treatment to potentially improve pregnancy outcomes but given the limited data further research is needed to determine the exact role of specific interventional therapy for subfertile men with impaired sperm chromatin.
Three‐dimensional printed dry lab training models to simulate robotic‐assisted pancreaticojejunostomy
Authors: Wei Fangqiang , Xu Mingen , Lai Xuecong , Zhang Jiye , Yiengpruksawan Anusak , Lu Yi , Liu Junwei , Wang Zhifei 
Published: November 2019

AbstractBackgroundThis pioneering study is aimed to design training models for robotic pancreaticojejunostomy (PJ) and to assess their usefulness using quality improvement exercise in the dry lab.MethodsThree dry lab models were developed including the anastomosis model of a transected silicon pancreatic stent (model 1), a rough model (model 2) simulating PJ, and an advanced three‐dimensional printed model (model 3) more vividly simulating PJ. Three surgeons (A, B, C) with same specialty and levels of expertise in surgery were enrolled in the training which was divided into three rounds of tasks. In the first round, all three surgeons (A, B, C) participated in the training on basic technical tasks before moved on to the next rounds. While surgeons A, B participated in the second round on model 1, only surgeon A worked on model 2 in the third round. Their proficiency of performance was evaluated on model 3.ResultsThe results of the first and second rounds between surgeons are similar. Surgeon A practiced with model 2 for 6 h, completing 10 cases. In model 3, the times of attempts before achieving a consecutively three times of satisfactory anastomosis procedures were compared, for surgeon A, six cases, 20 for B and 25 for C.ConclusionsThe specifically designed series of dry lab training models may be a potential training tool for advancing the robotic PJ through quality improvement exercise in dry lab. Further larger and well‐designed studies are warranted to validate this issue.
Clinical efficacy of bowel perfusion assessment during laparoscopic colorectal resection using laser speckle contrast imaging: A matched case–control study
Authors: Kojima Shigehiro , Sakamoto Tsuguo , Matsui Yutaka , Nambu Kyojiro , Masamune Ken 
Published: November 2019

AbstractIntroductionDisadvantages of bowel perfusion assessment with indocyanine green fluorescence angiography include the need for a fluorophore and the subjective nature of the assessment. This study was performed to evaluate the clinical efficacy of bowel perfusion assessment using laser speckle contrast imaging (LSCI) during laparoscopic colorectal surgery.MethodsThe study population comprised the first 27 consecutive patients who underwent laparoscopic left‐sided colorectal resection with intraoperative perfusion assessment using LSCI. The operative outcomes of these patients were compared with those of a matched group of patients without perfusion assessment. We analyzed the flux data expressed in laser speckle perfusion units.ResultsAfter propensity score matching, we found no significant between‐group differences in the patients' characteristics with the exception of the cancer stage. No patients undergoing LSCI perfusion assessment developed anastomotic leakage, but five (18.5%) patients in the control group did, at a significantly higher rate in male patients (P = .042). There were no significant differences in other operative outcomes. The laser speckle perfusion unit values after ligating marginal vessels were significantly lower than before ligation (P < .01).ConclusionsWith respect to anastomotic leakage, LSCI may improve patient outcomes after colorectal surgery. This technique appears to be a superior tool with the advantages of measurement repeatability and quantitativity and no need for a fluorophore.
Hospital bans on trial of labor after cesarean and antepartum transfer of care
Authors: Rosenstein Melissa G. , Norrell Laura , Altshuler Anna , Grobman William A. , Kaimal Anjali J. , Kuppermann Miriam 
Published: November 2019

AbstractBackgroundHospital policies restricting access to trial of labor after cesarean (TOLAC) are prevalent. Many women with a previous cesarean birth are affected by these bans, but there are limited data on the effect of these bans and whether women would consider changing delivery hospitals in the setting of a real or hypothetical TOLAC ban.MethodsThis was a survey of TOLAC‐eligible women receiving prenatal care at four hospitals where TOLAC is available, and 1 non‐TOLAC site. Participants were asked about their likelihood of switching hospitals to pursue TOLAC if it were unavailable. Women at the non‐TOLAC site had their medical records reviewed to ascertain final location and approach to delivery.ResultsA total of 297 women were interviewed, 48 from the non‐TOLAC site. 162 (54%) participants indicated they would transfer care if TOLAC were unavailable. Among women at the non‐TOLAC site, 57% who indicated an intention to switch hospitals did so. In a multivariable logistic regression model, variables associated with transferring care included race/ethnicity other than Latina (aOR 25.20 [95% CI 2.23‐284.26]), being unaware of the TOLAC ban (19.81 [1.99‐196.64]), and perceiving that a close friend/relative thought they should undergo TOLAC (17.31 [1.70‐176.06]).ConclusionsMore than half of women with prior cesarean would consider transferring care if TOLAC became unavailable, and more than 1 of 3 of women at a non‐TOLAC site transferred care. More research is needed on the impact of TOLAC bans and how to facilitate transfer for those who desire TOLAC.
Intestinal pathophysiological and microbial changes in sickle cell disease: Potential targets for therapeutic intervention
Authors: Dutta Dibyendu , Aujla Amandeep , Knoll Bettina M. , Lim Seah H. 
Published: November 2019

SummaryThere is a large therapeutic gap in the treatment of sickle cell disease (SCD). Recent studies demonstrated the presence of pathophysiological and microbial changes in the intestine of patients with SCD. The intestinal microbes have also been found to regulate neutrophil ageing and possible basal activation of circulating neutrophils. Both aged and activated neutrophils are pivotal for the pathogenesis of vaso‐occlusive crisis in SCD. In this paper, we will provide an overview of the intestinal pathophysiological and microbial changes in SCD. Based on these changes, we will propose therapeutic approaches that could be investigated for treating SCD.
Capn4 is induced by and required for Epstein‐Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP‐1 signaling
Authors: Zheng Peichan , Chen Xiong , Xie Jianqin , Chen Xi , Lin Shanshan , Ye Lixiang , Chen Lingfan , Lin Jing , Yu Xiangbin , Zheng Ming 
Published: November 2019

AbstractCapn4, also known as CapnS1, is a member of the calpain family, which plays a crucial role in maintaining the activity and function of calpain. We previously reported that Capn4 also plays an essential role in the migration of nasopharyngeal carcinoma (NPC) cells through regulation of (MMP‐2) by nuclear factor‐kappa B activation. Epstein‐Barr virus latent membrane protein 1 (LMP1) is closely related to the malignant functions of NPC; however, the relationship between LMP1 and Capn4 in NPC remain unclear. Immunohistochemical studies showed that the level of LMP1 and Capn4 expression was high in both primary and metastatic NPC tissues, with a significantly positive correlation. We further found that LMP1 was able to upregulate the Capn4 promoter in a dose‐dependent way through the C‐terminal activation region (CTAR)1 and CTAR2 domains to activate AP‐1. Moreover, we also found that LMP1 activated AP‐1 through ERK/JNK phosphorylation. These findings indicate that Capn4 coordination with LMP1 promotes actin rearrangement and, ultimately, cellular migration. These results show that Capn4 coordination with LMP1 enhances NPC migration by increasing actin rearrangement involving ERK/JNK/AP‐1 signaling. Therapeutically, additional and more specific LMP1 and Capn4 targeted inhibitors could be exploited to treat NPC.
Families on hold: How the context of an asylum centre affects parenting experiences
Authors: Lietaert Ine , Verhaeghe Floor , Derluyn Ilse 
Published: November 2019

AbstractMigration, especially under stressful circumstances, places pressure on parental capacities. At the same time, being part of a supportive family is of prime importance for the well‐being of migrating children and parents. In this paper, we highlight the impact of the living conditions in a collective asylum centre on asylum applicants' parenting experiences through in‐depth interviews with and participant observations among parents in a Belgian asylum centre. Differentiating between the influences of the organizational and physical environments of the centre, our results reveal that various organizational aspects limit parental agency and well‐being and often render parents powerless in raising and protecting their children. Their physical environment, consisting of a dilapidated building, is experienced as a nonwelcoming, dangerous environment that leaves insufficient opportunity to establish a safe and stable home. We conclude that there is almost no attention paid to asylum applicants' parental role within the collective reception facilities. Further, their individual parental responsibility is emphasized, whereas the difficult environment of the asylum centre in which they have to raise their children is not criticized.
Kidney function in minority children and adolescents with metabolically healthy and unhealthy obesity
Authors: Arora Sumeet , Dunkley Laura , Waldman Lee M. , Chin Vivian L. , Umpaichitra Vatcharapan 
Published: November 2019

SummaryMetabolic syndrome and/or body mass index (BMI) ≥40 kg/m2 are risk factors for kidney function decline in the general population. To compare creatinine (Cr), estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN) between minority children and adolescents with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO), a chart review was conducted on subjects aged 4 to 20 years with BMI ≥95th percentile from July 2014 to April 2017. They were stratified into MHO and MUO groups. Cr, eGFR and BUN were studied. Total n = 277: MHO n = 105 vs MUO n = 172. Cr was higher and BUN was lower in MUO whereas eGFR did not differ between the groups. Using general linear model, we found that metabolic status predicted BUN (P = .009) but not Cr or eGFR. When age, sex and Tanner stage matched, BUN, Cr and eGFR were similar between the groups. Higher BUN in MHO could be due to higher dietary protein intake. Subjects were divided into BMI ≥40 vs <40 kg/m2, BUN and eGFR were not different. A trend towards higher Cr in those with BMI ≥40 kg/m2 (P = .054) was found; the group being older and taller. After age and height matching, all outcomes were not different. Higher Cr was found in those with elevated blood pressures vs the MHO (P = .047). Those with diastolic blood pressure (DBP) ≥90th percentile had higher Cr than those with systolic blood pressure ≥90th percentile (P = .017). Children and adolescents with MUO, and those with BMI ≥40 kg/m2 did not appear to have early diminished kidney function. Higher Cr, although in normal range, occurred in those with abnormal DBP.