bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Aging in East Asia: Comparison Among China, Korea, and Japan
Authors: Nakagawa Takeshi , Cho Jinmyoung , Yeung Dannii Y 
Published: March 2020

Abstract

Objectives
Heterogeneity in successful aging has been found across countries. Yet, comparable evidence is sparse except in North America and Europe. Extending prior research, this study examined the prevalence and correlates of successful aging in East Asia: China, Korea, and Japan.

Method
We used harmonized data sets from national surveys. A total of 6,479 participants (aged between 65 and 75) were analyzed. Using Rowe and Kahn’s (1987, 1997) model, successful aging was defined as having no major diseases, no difficulty performing activities of daily living, obtaining a median or higher score on tests of cognitive function, and being actively engaged.

Results
The average prevalence of successful agers was 17.6%. There were variations in the global and specific measures of successful aging within and across countries, even after controlling for individual sociodemographic factors (age, gender, and education). The odds of aging successfully were highest in Japan and lowest in China, especially in the rural areas. Being younger and males were associated with a higher likelihood of successful agers in both global and specific measures.

Discussion
This study observed heterogeneity in successful aging in East Asia. To identify policy implications, future research should explore potential societal factors influencing individuals’ opportunities for successful aging.
Antipodal observations of global differential times of diffracted P and PKPAB within the D″ layer above Earth's core–mantle boundary
Authors: Butler Rhett , Tsuboi Seiji 
Published: March 2020

SUMMARYAntipodal diffracted, compressional wave (Pdiff) data analysed diametrically opposite three large earthquakes have uniformly sampled 99% of the laterally heterogeneous zone above Earth's core–mantle boundary (D″ in seismic nomenclature). These antipodal data offer a fundamental gross Earth datum—a robust, global constraint on the average compressional velocity at the base of the mantle. We use for the first time the seismic phase PKPAB as a reference, which travels an identical mantle path as Pdiff, thereby cancelling common mantle heterogeneity. Differential traveltimes between Pdiff, PKPAB and PKIKP are measured, appropriately making allowance for the phase shifts acquired in propagation. We have independently confirmed the $\pi /4$ polar phase shift of Pdiff at the antipode. The global mean PKPAB − Pdiff time is 136.5 ± 0.6 s. The global mean apparent velocity (13.05 km s−1) and ray parameter (4.65 ± 0.01 s deg−1) are within the margin of error of prior Pdiff studies—which were dominated by Northern Hemisphere paths—indicating that complementary, southern hemisphere paths have a comparable, mean Pdiff apparent velocity. The seismic velocity constraints afforded by antipodal Pdiff and PKPAB suggest that the heterogeneous processes already observed in D″ may be broadly ascribed where D″ coverage has been lacking or poorly resolved.
Thinking outside the box: embracing social complexity in aquaculture carrying capacity estimations
Authors: Kluger Lotta Clara , Filgueira Ramón 
Published: March 2020

Abstract
With ever-expanding marine aquaculture, calls for sustainable development become louder. The concept of aquaculture carrying capacity (CC) emerged 30 years ago to frame development, though so far, most studies have focused on the production and ecological components, leaving aside the social perspective. Often, estimations are carried out a posteriori, once aquaculture is already in place, hence ignoring relevant voices potentially opposing the onset of aquaculture implementation. We argue that CC should be multidimensional, iterative, inclusive, and just. Hence, the evaluative scope of CC needs to be broadened by moving from industry-driven, Western-based approaches towards an inclusive vision taking into consideration historical, cultural, and socio-economic concerns of all stakeholders of a given area. To this end, we suggest guidelines to frame a safe operating space for aquaculture based on a multi-criteria, multi-stakeholder approach, while embracing the social-ecological dynamics of aquaculture settings by applying an adaptive approach and acknowledging the critical role of place-based constraints. Rather than producing a box-checking exercise, CC approaches should proactively engage with aquaculture-produced outcomes at multiple scales, embracing complexity, and uncertainty. Scoping CC with the voices of all relevant societal groups, ideally before aquaculture implementation, provides the unique opportunity to jointly develop truly sustainable aquaculture.
Long non-coding RNA MIAT promotes cervical cancer proliferation and migration
Authors: Zhang Lei , Ge Shuxia , Cao Bing 
Published: March 2020

Abstract
Cervical cancer is one of the most common cancers in the world while its pathological mechanisms are not well-elucidated. Long non-coding RNA (lncRNA) has been implicated in cancer development. The dysregulation of lncRNA myocardial infarction-associated transcript (MIAT) has been reported in several cancers while its role in cervical cancer is not described yet. In this study, the role of MIAT in cervical cancer was explored. We evaluated the expression of MIAT in cervical cancer tissues and cell lines. Furthermore, we explored the effects of MIAT on proliferation and invasion of cervical cancer using cell model and animal transplantation model. We also evaluated the effects of MIAT on activation of PI3K/Akt/mTOR signalling pathway. Our results show that MIAT was up-regulated in cervical cancer tissues and cell lines. Knocking down MIAT resulted in decreased cell proliferation, migration and invasion of cervical cancer cells and suppression of tumour growth in mice. Mechanically, knocking down MIAT suppressed the activation of PI3K/Akt signalling pathway. In conclusion, MIAT promotes cell proliferation and invasion in cervical cancer.
Electron microscopy using ionic liquids for life and materials sciences
Authors: Tsuda Tetsuya , Kuwabata Susumu 
Published: March 2020

AbstractAn ionic liquid (IL) is a salt consisting of only cations and anions, which exists in the liquid state at room temperature. Interestingly ILs combine various favorable physicochemical properties, such as negligible vapor pressure, flame resistance, relatively high ionic conductivity, wide electrochemical window, etc. To take advantage of two specific features of ILs, viz. their nonvolatile and antistatic nature, in 2006, Kuwabata, Torimoto et al. reported a milestone study led to current IL-based electron microscopy techniques. Thereafter, several IL-based electron microscopy techniques have been proposed for life science and materials science applications, e.g. pretreatment of hydrous and/or non-electron conductive specimens and in situ/operando observation of chemical reactions occurring in ILs. In this review, the fundamental approaches for making full use of these techniques and their impact on science and technology are introduced.
Computational Modeling of Neuropsychological Test Performance to Disentangle Impaired Cognitive Processes in Cancer Patients
Authors: Agelink van Rentergem Joost A , Vermeulen Ivar E , Lee Meeuw Kjoe Philippe R , Schagen Sanne B 
Published: March 2020

AbstractThere is a need to better identify impaired cognitive processes to increase our understanding of cognitive dysfunction caused by cancer and cancer treatment and to improve interventions. The Trail Making Test is frequently used for evaluating information-processing speed (part A) and executive function (part B), but interpretation of its outcomes is challenging because performance depends on many cognitive processes. To disentangle processes, we collected high-resolution data from 192 non–central nervous system cancer patients who received systemic therapy and 192 cancer-free control participants and fitted a Shifted-Wald computational model. Results show that cancer patients were more cautious than controls (Cohen d = 0.16). Patients were cognitively slower than controls when the task required task switching (Cohen d = 0.16). Our results support the idea that cancer and cancer treatment accelerate cognitive aging. Our approach allows more precise assessment of cognitive dysfunction in cancer patients and can be extended to other instruments and patient populations.
Late Effects in Survivors of Adolescent and Young Adult Acute Lymphoblastic Leukemia
Authors: Muffly Lori , Maguire Frances B , Li Qian , Kennedy Vanessa , Keegan Theresa H 
Published: March 2020

Abstract

Background
Knowledge regarding late effects (medical conditions and subsequent neoplasms) in survivors of adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) is lacking.

Methods
Using the population-based California Cancer Registry linked with California hospitalization data, we evaluated late effects in 1069 AYAs (aged 15–39 years) diagnosed with ALL in California between 1995 and 2012 and surviving a minimum of 3 years from diagnosis.

Results
The estimated 10-year cumulative incidence of subsequent endocrine disease (28.7%, 95% confidence interval [CI] = 25.8% to 31.6%) and cardiac disease (17.0%, 95% CI = 14.6% to 19.5%) were strikingly high; avascular necrosis (9.6%, 95% CI = 7.8% to 11.6%), liver disease (6.5%, 95% CI = 5.0% to 8.3%), respiratory disease (6.2%, 95% CI = 4.8% to 8.0%), seizure and/or stroke (4.3%, 95% CI = 3.1% to 5.8%), renal disease (3.1%, 95% CI = 2.1% to 4.4%), and second neoplasms (1.4%, 95% CI = 0.7% to 2.4%) were estimated to occur at 10 years with the reported frequencies. Multivariable analyses including the entire patient cohort demonstrated that public or no insurance (vs private and/or military insurance) and receipt of hematopoietic cell transplantation were independently associated with the occurrence of all late effects considered. In multivariable analyses limited to the 766 AYAs who were not transplanted, we continued to find a statistically significant association between public and no insurance and the occurrence of all late effects. Frontline regimen type (pediatric vs adult) was not statistically significantly associated with any of the late effect categories.

Conclusions
This large population-based analysis is among the first to describe late effects in survivors of AYA ALL. The strong association between insurance type and late effects suggests that AYAs with public or no insurance may have reduced access to survivorship care following completion of ALL therapy.
Language endangerment: a multidimensional analysis of risk factors
Authors: Bromham L , Hua X , Algy C , Meakins F 
Published: March 2020

AbstractThe world is facing a crisis of language loss that rivals, or exceeds, the rate of loss of biodiversity. There is an increasing urgency to understand the drivers of language change in order to try and stem the catastrophic rate of language loss globally and to improve language vitality. Here we present a unique case study of language shift in an endangered Indigenous language, with a dataset of unprecedented scale. We employ a novel multidimensional analysis, which allows the strength of a quantitative approach without sacrificing the detail of individual speakers and specific language variables, to identify social, cultural, and demographic factors that influence language shift in this community. We develop the concept of the ‘linguatype’, a sample of an individual’s language variants, analogous to the geneticists’ concept of ‘genotype’ as a sample of an individual’s genetic variants. We use multidimensional clustering to show that while family and household have significant effects on language patterns, peer group is the most significant factor for predicting language variation. Generalized linear models demonstrate that the strongest factor promoting individual use of the Indigenous language is living with members of the older generation who speak the heritage language fluently. Wright–Fisher analysis indicates that production of heritage language is lost at a significantly faster rate than perception, but there is no significant difference in rate of loss of verbs vs nouns, or lexicon vs grammar. Notably, we show that formal education has a negative relationship with Indigenous language retention in this community, with decreased use of the Indigenous language significantly associated with more years of monolingual schooling in English. These results suggest practical strategies for strengthening Indigenous language retention and demonstrate a new analytical approach to identifying risk factors for language loss in Indigenous communities that may be applicable to many languages globally.
Ingestion of razor blades, a rare event: a case report in a psychiatric patient
Authors: Delgado Salazar Jhony Alejandro , Naveda Pacheco Natalia Carolina , Palacios Jaramillo Paola Alexandra , Garzón Yépez Santiago Danilo , Medina Loza Victor Rafael , Romero Alvarado Carlos Alberto , Aguilar Ayala Bernabé Esteban , Molina Gabriel Alejandro 
Published: March 2020

Abstract
Foreign body ingestion is a common condition in clinical practice, thankfully most of the cases do not require any surgery as most foreign bodies can pass through the bowel without injuring it. Treatment depends on the size and kind of foreign bodies. When complications arise, patients may require urgent medical attention. Self-harm by sharp foreign body ingestion is a rare event that must always be promptly treated and should always be prevented. Psychiatric patients and inmates are the most affected population. A high index of suspicion is required to treat this rare condition, which may be preventable if there is adequate mental and medical therapy along with close monitoring and family support. We present the case of a 31-year-old psychiatric patient. After prompt treatment, two razor blades were surgically removed from her intestines. She fully recovered and is doing well on follow-up controls.
A Glint From The Kāmasūtra in al-Ǧāḥiẓ's Kitāb Al-Ḥayawān
Authors: Kahl Oliver 
Published: March 2020

Abstract
This article investigates an apparent quotation from Vātsyāyana's (fl. late third century ce) Kāmasūtra in al-Ǧāḥiẓ's (d. 255/869) Kitāb al-Ḥayawān or ‘Book of Animals’, from its original Sanskrit form through to the guise it assumes in the Arabic text. Evidence is furnished for an oral transmission at the hands of non-literary circles, showing how a given statement's content may considerably be altered without its origins being effaced. The possibilities and limitations of identifying and tracing a vague representation of a Sanskrit saying in Arabic garb are illustrated here through a detailed case study of one extant specimen.
Three-dimensional episodic model of star formation in galaxies in the presence of dissipation
Authors: Das Sukanta , Chattopadhyay Tanuka , Mukherjee Sailajananda 
Published: March 2020

ABSTRACTThe oscillatory model of star formation in giant and dwarf galaxies have been studied through a dynamical open system. In addition to various dynamical processes involving fractional masses of hot, warm, and cold gases, the system is subjected to dissipative processes e.g. outflow from the gaseous component caused by supernovae explosion and subsequent ram pressure stripping within the oscillation period. This is more realistic than a previous model which was considered conservative. The present episodic model has been found to be unimodal in general contrary to discrete episodes of star formation of decreasing amplitudes as found for closed systems. The duty cycles under various parametric conditions derived, vary in the range (2.0–40.0) × 107 yr for giant galaxies contrary to longer time, for example 9.0 × 107–1.0 × 109 yr for dwarf galaxies. This might be due to the low production rate of supernova in dwarf galaxies which reduces the evaporation rate of cold gas into hot gas making cold gas available for continuing the cycle for a longer time. The duty cycles have increased in both cases compared to the previous model by an order of one for giant galaxies and order of two for dwarf galaxies depending on the degree of dissipation. This might be due to the unimodal pattern of star formation which prevails for longer time in the late phase of galaxy evolution. Under very special parametric conditions limit cycles may occur i.e. star formation in discrete episodes, may occur involving one or more stable attractors especially in early-type dwarf and giant galaxies. Tendency of formation of multiple attractors are more likely in early-type giant spiral galaxies when the rate of dissipation is very slow.
Chemodynamics of green pea galaxies – I. Outflows and turbulence driving the escape of ionizing photons and chemical enrichment
Authors: Hogarth L , Amorín R , Vílchez J M , Hägele G F , Cardaci M , Pérez-Montero E , Firpo V , Jaskot A , Chávez R 
Published: March 2020

ABSTRACT
We investigate the ionized gas kinematics, physical properties, and chemical abundances of Sloan Digital Sky Survey J142947, a Green Pea galaxy at redshift z∼ 0.17 with strong, double-peak Ly α emission and indirect evidence of Lyman continuum (LyC) leakage. Using high-dispersion spectroscopy, we perform a multicomponent analysis of emission-line profiles. Our model consistently fits all lines as a narrow component with intrinsic velocity dispersion σ ∼ 40 km s−1, and two broader blue-shifted components with σ ∼ 90 and ∼ 250 km s−1. We find electron densities and temperatures, ionization conditions, and direct O/H and N/O abundances for each component. A highly ionized, metal-poor, young and compact starburst dominates narrow emission, showing evidence of hard radiation fields and elevated N/O. The blue-shifted broader components are consistent with highly turbulent, possibly clumpy ionized gas at the base of a strong photoionized outflow, which accounts for ≳50 per cent of the integrated emission-line fluxes. The outflow is dense and metal-enriched compared to the H ii regions, with expansion velocities larger than those obtained from UV interstellar absorption lines under standard assumptions. Some of these metals may be able to escape, with outflows loading factors comparable to those found in high-z galaxies of similar SFR/Area. Our findings depict a two-stage starburst picture; hard radiation fields from young star clusters illuminate a turbulent and clumpy ISM that has been eroded by SNe feedback. Whilst UV data suggest an extended Ly α halo with high average H i column density, LyC photons could only escape from SDSS J142947 through low H i density channels or filaments in the ISM approaching density-bounded conditions, traced by outflowing gas.
Potassium bromate as positive assay control for the Fpg-modified comet assay
Authors: Møller Peter , Muruzabal Damian , Bakuradze Tamara , Richling Elke , Bankoglu Ezgi Eyluel , Stopper Helga , Langie Sabine A S , Azqueta Amaya , Jensen Annie , Scavone Francesca , Giovannelli Lisa , Wojewódzka Maria , Kruszewski Marcin , Valdiglesias Vanessa , Laffon Blanca , Costa Carla , Costa Solange , Teixeira João Paulo , Marino Mirko , Del Bo’ Cristian , Riso Patrizia , Shaposhnikov Sergey , Collins Andrew 
Published: March 2020

Abstract
The comet assay is a popular assay in biomonitoring studies. DNA strand breaks (or unspecific DNA lesions) are measured using the standard comet assay. Oxidative stress-generated DNA lesions can be measured by employing DNA repair enzymes to recognise oxidatively damaged DNA. Unfortunately, there has been a tendency to fail to report results from assay controls (or maybe even not to employ assay controls). We believe this might have been due to uncertainty as to what really constitutes a positive control. It should go without saying that a biomonitoring study cannot have a positive control group as it is unethical to expose healthy humans to DNA damaging (and thus potentially carcinogenic) agents. However, it is possible to include assay controls in the analysis (here meant as a cryopreserved sample of cells i.e. included in each experiment as a reference sample). In the present report we tested potassium bromate (KBrO3) as a positive comet assay control for the formamidopyrimidine DNA glycosylase (Fpg)-modified comet assay. Ten laboratories used the same procedure for treatment of monocytic THP-1 cells with KBrO3 (0.5, 1.5 and 4.5 mM for 1 h at 37°C) and subsequent cryopreservation. Results from one laboratory were excluded in the statistical analysis because of technical issues in the Fpg-modified comet assay. All other laboratories found a concentration–response relationship in cryopreserved samples (regression coefficients from 0.80 to 0.98), although with different slopes ranging from 1.25 to 11.9 Fpg-sensitive sites (%DNA in tail) per 1 mM KBrO3. Our results demonstrate that KBrO3 is a suitable positive comet assay control.
A call for harmonization of European kidney care: dialysis reimbursement and distribution of kidney replacement therapies
Authors: van der Tol Arjan , Stel Vianda S , Jager Kitty J , Lameire Norbert , Morton Rachael L , Van Biesen Wim , Vanholder Raymond 
Published: March 2020

Abstract

Background
We compare reimbursement for haemodialysis (HD) and peritoneal dialysis (PD) in European countries to assess the impact on government healthcare budgets. We discuss strategies to reduce costs by promoting sustainable dialysis and kidney transplantation.

Methods
This was a cross-sectional survey among nephrologists conducted online July–December 2016. European countries were categorized by tertiles of gross domestic product per capita (GDP). Reimbursement data were matched to kidney replacement therapy (KRT) data.

Results
The prevalence per million population of patients being treated with long-term dialysis was not significantly different across tertiles of GDP (P = 0.22). The percentage of PD increased with GDP across tertiles (4.9, 8.2, 13.4%; P &lt; 0.001). The HD-to-PD reimbursement ratio was higher in countries with the highest tertile of GDP (0.7, 1.0 versus 1.7; P = 0.007). Home HD was mainly reimbursed in countries with the highest tertile of GDP (15, 15 versus 69%; P = 0.005). The percentage of public health expenditure for reimbursement of dialysis decreased across tertiles of GDP (3.3, 1.5, 0.7%; P &lt; 0.001). Transplantation as a proportion of all KRT increased across tertiles of GDP (18.5, 39.5, 56.0%; P &lt; 0.001).

Conclusions
In Europe, dialysis has a disproportionately high impact on public health expenditure, especially in countries with a lower GDP. In these countries, the cost difference between PD and HD is smaller, and home dialysis and transplantation are less frequently provided than in countries with a higher GDP. In-depth evaluation and analysis of influential economic and political measures are needed to steer optimized reimbursement strategies for KRT.