bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attribution analysis of climatic and multiple anthropogenic causes of runoff change in the Loess Plateau—A case‐study of the Jing River Basin
Authors: Gao Xuerui , Yan Chengsheng , Wang Yubao , Zhao Xining , Zhao Yong , Sun Miao , Peng Shouzhang 
Published: January 2020

AbstractOver the past five decades, under the joint influence of climate change and human activity, river runoff in most areas of Loess Plateau showed a significant declining trend, which poses a great threat to ecological security and land degradation and soil erosion control. To identify the key factors controlling this decline and quantify the contribution rates of the multiple factors, a runoff simulation was established based on the Soil Water Assessment Tool (SWAT), and the influence of climatic and anthropogenic factors on runoff change was calculated by comparing the results of the simulation based on different modeling scenarios. First, the impact of climatic factors on runoff change was gradually decreasing over time, and the anthropogenic factors’ impact was increasing based on the runoff observations. Second, the SWAT model proved to be reliable and acceptable for both the calibration and the validation periods, with R
2 and Nash–Sutcliffe efficiency values both above .8. Third, the influence of climatic factors decreases from 85.70% to 42.43% but that of anthropogenic factors increases from 14.3% to 57.57% in different subperiods. Among the anthropogenic factors, the influence of the direct factor (water withdrawal) is growing the fastest, and the influence of indirect factors is increasing continuously. Therefore, future ecological management and water‐related planning in Loess Plateau should consider the importance of human activity and the relationship between humans and the Earth. Finally, a range of comprehensive countermeasures are proposed to assist with sustainable watershed management in the Loess Plateau.
Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties
Authors: Mojicevic Marija , D'Agostino Paul M. , Pavic Aleksandar , Vojnovic Sandra , Senthamaraikannan Ramsankar , Vasiljevic Branka , Gulder Tobias A. M. , Nikodinovic‐Runic Jasmina 
Published: January 2020

AbstractApplying a bioactivity‐guided isolation approach, staurosporine was separated and identified as the active principle in the culture extract of the new isolate Streptomyces sp. BV410 collected from the chamomile rhizosphere. The biotechnological production of staurosporine by strain BV410 was optimized to yield 56 mg/L after 14 days of incubation in soy flour–glucose–starch–mannitol‐based fermentation medium (JS). The addition of FeSO4 significantly improved the staurosporine yield by 30%, while the addition of ZnSO4 significantly reduced staurosporine yield by 62% in comparison with the starting conditions. Although staurosporine was first isolated in 1977 from Lentzea albida (now Streptomyces staurosporeus) and its potent kinase inhibitory effect has been established, here, the biological activity of this natural product was assessed in depth in vivo using a selection of transgenic zebrafish (Danio rerio) models, including Tg(fli1:EGFP) with green fluorescent protein‐labeled endothelial cells allowing visualization and monitoring of blood vessels. This confirmed a remarkable antiangiogenic activity of the compound at doses of 1 ng/ml (2.14 nmol/L) which is below doses inducing toxic effects (45 ng/ml; 75 nmol/L). A new, efficient producing strain of commercially significant staurosporine has been described along with optimized fermentation conditions, which may lead to optimization of the staurosporine scaffold and its wider applicability.
RETRACTED: Comprehensive genetic structure analysis of Han population from Dalian City revealed by 20 Y‐STRs
Authors: Adnan Atif , Kasimu Kaidirina , Rakha Allah , He Guanglin , Yang Tongya , Wang Chuan‐Chao , Lu Jie , Xuan Jin‐feng 
Published: January 2020

AbstractBackgroundDalian is a city formed in the 1880s in Liaoning province, Northeastern China with a population of 6.69 million now. Han is the largest ethnic group not only across Mainland China (92%) and Taiwan (97%) but also considered to be the largest ethnic group of the world contributing to above 18% of world's population.MethodsIn the current study, we genotyped Goldeneye® 20Y System loci in 879 unrelated male individuals from the Han ethnic group in Dalian city and calculated the forensic parameters of the 20 Y‐STR loci.ResultsIn total, we observed 855 haplotypes, among which 835 (94.99%) were unique. The discrimination capacity (DC) of overall Goldeneye® 20Y System is 97.27% and it slightly reduces to 96.93% when only Y‐filer® set of 17 Y‐STRs were used, which mitigates using the extended set of markers in this population. We found DYS388 showed the lowest gene diversity (0.5151), whereas DYS389II showed the highest gene diversity (0.7621) in single copy Y‐STR, and DYS385 showed the highest gene diversity (0.9683) among all.ConclusionMultidimensional scaling (MDS) analysis based upon pairwise Rst genetic distance showed difference among Han population from the east to the west and from the north to the south. We also predicted haplogroups using Y‐STR haplotypes, which showed the dominance of Haplogroup O (65.2%) followed by Haplogroup C (14.5%) in Dalian Han population. Moreover, we found 10 individuals showed a null allele at the DYS448 in our samples. We also performed linear discriminatory analysis (LDA) between Han and other prominent Chinese minority ethnic groups. We presented Y‐STRs data in the Y‐Chromosome Haplotype Reference Database (YHRD) for the future forensic and other usage.
The Effect of Lactobacillus fermentum ME‐3 Treatment on Glycation and Diabetes Complications
Authors: Guilbaud Axel , Howsam Michael , Niquet‐Léridon Céline , Delguste Florian , Fremont Marc , Lestavel Sophie , Maboudou Patrice , Garat Anne , Schraen Susanna , Onraed Brigitte , Foligné Benoît , Boulanger Éric , Tessier Frédéric J 
Published: January 2020

ScopeType 2 diabetes (T2D) induces organ damage associated with glycation, among other metabolic pathways. While therapeutic strategies have been tested to reduce the formation and impact of glycation products, results remain equivocal. Anti‐diabetic therapies using probiotics have been proposed, but their effect upon glycation has not been reported. Here, the effects of the bacterial strain Lactobacillus fermentum ME‐3 on glycation and T2D‐related complications in a mouse model of T2D are investigated.Methods & ResultsWild‐type LepRdb/+ and diabetic LepRdb/db littermates receive a daily gavage of either water or the probiotic ME‐3 strain (1010 CFU). Glycation markers, fructoselysine‐derived furosine (FL‐furosine) and carboxymethyllysine (CML), are quantified in four major organs and plasma using stable‐isotope dilution LC–MS/MS. After 12 weeks of ME‐3 treatment, diabetic mice gain less weight and exhibit an apparently improved glucose tolerance. The ME‐3 treatment reduces median renal levels of FL‐furosine in both genotypes by 12–15%, and renal and pulmonary free‐CML in diabetic mice by 30% and 18%, respectively. Attenuated hepatic steatosis and an improved plasma lipid profile are also observed with treatment in both genotypes, while the gut microbiota profile is unchanged.ConclusionL. fermentum ME‐3 has therapeutic potential for reducing the formation/accumulation of some glycation products in kidneys and attenuating some common diabetes‐related complications.
Nutrition Provider Isolation Is Related to Increased Preference for Enteral Nutrition–Support in Patients With Advanced Dementia
Authors: Douglas Joy W. , Lawrence Jeannine C. , Knol Linda L. , Turner Lori W. , Ellis Amy C. 
Published: January 2020

AbstractBackgroundCurrent guidelines advise against using enteral nutrition (EN) support for patients with advanced dementia (AD) because of negative outcomes. However, research suggests that some registered dietitian nutritionists (RDNs) in acute‐care settings still recommend EN for this patient population. The purpose of this study was to identify workplace characteristics that influence the EN recommendations of acute‐care RDNs who care for patients with AD.MethodsA random sample of 5000 RDNs in the United States were invited to participate in a web‐based survey in which RDNs self‐reported the likelihood that they would recommend EN for a patient with AD. Inclusion criteria specified that participants were at least 18 years of age, were an RDN in the United States, and currently provide nutrition care to older adults with dementia. χ2 tests compared RDN recommendations by workplace characteristics. Logistic regression was used to determine factors associated with recommending EN for patients with AD.ResultsRespondents included 204 acute‐care RDNs. RDNs in rural or suburban locations were 2.4 times more likely to recommend EN compared with those in urban facilities (95% CI, 1.1–5.1). RDNs who were the only nutrition provider at their facility were 3.3 times more likely to recommend EN than those in facilities with multiple RDNs (95% CI, 1.4–7.9).ConclusionAcute‐care RDNs who are isolated either in rural facilities or because they lack other RDN colleagues at their facility may benefit from targeted interventions to increase knowledge and promote adherence to evidence‐based guidelines.
Low‐field benchtop NMR spectroscopy: status and prospects in natural product analysis†
Authors: van Beek Teris André 
Published: January 2020

AbstractIntroductionSince a couple of years, low‐field (LF) nuclear magnetic resonance (NMR) spectrometers (40–100 MHz) have re‐entered the market. They are used for various purposes including analyses of natural products. Similar to high‐field instruments (300–1200 MHz), modern LF instruments can measure multiple nuclei and record two‐dimensional (2D) NMR spectra.ObjectiveTo review the commercial availability as well as applications, advantages, limitations, and prospects of LF‐NMR spectrometers for the purpose of natural products analysis.MethodCommercial LF instruments were compared. A literature search was performed for articles using and discussing modern LF‐NMR. Next, the articles relevant to natural products were read and summarised.ResultsSeventy articles were reviewed. Most appeared in 2018 and 2019. Low costs and ease of operation are most often mentioned as reasons for using LF‐NMR.ConclusionAs the spectral resolution of LF instruments is limited, they are not used for structure elucidation of new natural products but rather applied for quality control (QC), forensics, food and health research, process control and teaching. Chemometric data handling is valuable. LF‐NMR is a rapidly developing niche and new instruments keep being introduced.
Mobile no more? The innovative use of administrative data linked to a census‐based longitudinal study to investigate migration within Scotland
Authors: McCollum David , Ernsten‐Birns Annemarie , Feng Zhiqiang , Everington Dawn 
Published: January 2020

AbstractThis paper builds upon existing scholarship on changing patterns and processes of internal migration, especially the surprising recently documented trend towards falling internal migration intensities since the late 20th century in many developed countries. The analysis is based on new research opportunities presented by the recent linking of administrative health data into the census‐based Scottish Longitudinal Study and points to a modest recent decrease in aggregate rates of address changing within Scotland. This decline is partly driven by the population subgroups that have been conventionally most mobile, especially over longer distances, becoming less migratory. This supports the notion of an evening out of some of the main socio‐economic determinants of migration and validates calls for a greater emphasis on the drivers and consequences of population immobility within migration studies.
Adaptive composite suboptimal control for linear singularly perturbed systems with unknown slow dynamics
Authors: Yang Chunyu , Zhong Shanshan , Liu Xiaomin , Dai Wei , Zhou Linna 
Published: January 2020

SummaryIn this article, using singular perturbation theory and adaptive dynamic programming (ADP) approach, an adaptive composite suboptimal control method is proposed for linear singularly perturbed systems (SPSs) with unknown slow dynamics. First, the system is decomposed into fast‐ and slow‐subsystems and the original optimal control problem is reduced to two subproblems in different time‐scales. Afterward, the fast subproblem is solved based on the known model of the fast‐subsystem and a fast optimal control law is designed by solving the algebraic Riccati equation corresponding to the fast‐subsystem. Then, the slow subproblem is reformulated by introducing a system transformation for the slow‐subsystem. An online learning algorithm is proposed to design a slow optimal control law by using the information of the original system state in the framework of ADP. As a result, the obtained fast and slow optimal control laws constitute the adaptive composite suboptimal control law for the original SPSs. Furthermore, convergence of the learning algorithm, suboptimality of the adaptive composite suboptimal control law and stability of the whole closed‐loop system are analyzed by singular perturbation theory. Finally, a numerical example is given to show the feasibility and effectiveness of the proposed methods.
Event‐triggered observer‐based robust H∞ control for networked control systems with unknown disturbance
Authors: Li Tao , Wang Ting , Zhai Junyong , Fei Shumin 
Published: January 2020

SummaryIn this article, the event‐triggered robust H∞ control is studied for a class of uncertain networked control systems (NCSs) subject to unknown state and variable disturbance. First, aiming to decrease the unnecessary transmissions of sampled data, an efficient adaptive event‐triggered scheme (AETS) is presented, which can reflect the full real‐time variation of addressed NCSs and help to reduce the conservativeness. Second, based on the triggered output signals and disturbance model, two effective observers are, respectively, exploited to estimate the state and disturbance, which are further utilized to reject the disturbance and design the controller. By using the overall closed‐loop system and selecting an augmented Lyapunov‐Krasovskii functional, two sufficient conditions on jointly designing the adaptive event scheme, observers, and controller are established via linear matrix inequality forms, which can guarantee the global exponential stability and ensure H∞ performance. Finally, some simulations and comparisons in a numerical example are provided to demonstrate the effectiveness of the derived results.
Effects of river ice break‐up on organic‐matter dynamics and feeding ecology of aquatic insects
Authors: Blackadar Ryan J. , Baxter Colden V. , Davis John M. , Harris Hannah E. 
Published: January 2020

AbstractDisturbance shapes the structure and function of aquatic communities and ecosystems, but the dynamics of ice are a less studied dimension of the disturbance‐regime of rivers. We investigated effects of a river‐ice regime on organic‐matter dynamics and feeding ecology of aquatic insects. Samples of biofilm and aquatic insects for gut content analysis were collected monthly from Big Creek, a sixth ‐ order tributary of the Middle Fork Salmon River in central Idaho, USA, during winter 2010–2011. Our results indicate that river ice affects both quantity and quality of organic matter available to, and used by, consumers. Specifically, scour from December and February ice break‐up events reduced biofilm biomass by one‐half and one‐third, respectively, whereas quality (chlorophyll‐a: ash‐free dry mass) increased. Diets of scrapers, Rhithrogena (Heptageniidae) and Bibiocephala (Blephariceridae), collector‐gatherers, Baetis (Baetidae), and collector‐filterers, Simulium (Simulidae) appeared to follow patterns of organic matter. Following ice break‐up events, diets of these taxa had increased proportions of diatom frustules, which are high‐quality food resources due to their relatively high nutrient content. Other taxa, such as collector‐gatherers, non‐Tanypodinae (Chironomidae), and the collector‐filterer, Arctopsyche grandis (Hydropsychidae), consistently consumed high proportions of diatom frustules and insect material, respectively, suggesting they were able to feed more selectively throughout winter. Our study indicates that ice regimes in temperate rivers can affect organic‐matter dynamics and feeding ecology of aquatic insects, a possibility that deserves additional investigation, particularly in light of potential changes to the ice regimes of rivers with changing climate.
Sediment storage and shallow groundwater response to beaver dam analogues in the Colorado Front Range, USA
Authors: Scamardo Julianne , Wohl Ellen 
Published: January 2020

AbstractEnthusiasm for using beaver dam analogues (BDAs) to restore incised channels and riparian corridors has been increasing. BDAs are expected to create a similar channel response to natural beaver dams by causing channel bed aggradation and overbank flow, which subsequently raise water tables and support vegetation growth. However, lack of funding for monitoring projects post‐restoration has limited research on whether BDAs actually cause expected channel change in the Front Range and elsewhere. Geomorphic and hydrologic response to BDAs was monitored in two watersheds 1 year post‐restoration. BDAs were studied at Fish Creek, a steep mountainous catchment, and Campbell Creek, a lower gradient piedmont catchment from May to October 2018. At each restoration site, the upstream‐ and downstream‐most BDAs were chosen for intensive study in comparison with unrestored reference reaches. Monitoring focused on quantifying sediment volumes in BDA ponds and recording changes to stream stage and riparian groundwater. Despite differences in physical basin characteristics, BDA pools at both sites stored similar volumes of sediment and stored more sediment than reference pools. Sediment storage is positively correlated to BDA height and pool surface area. However, BDAs did not have a significant influence on shallow groundwater. The lack of groundwater response proximal to BDAs could indicate that local watershed factors have a stronger influence on groundwater response than restoration design 1 year post‐restoration. Systematic, long‐term studies of channel and floodplain response to BDAs are needed to better understand how BDAs will influence geomorphology and hydrology.
Associations of dicarbonyl stress with complement activation: the CODAM study
Authors: Xin Ying , Hertle Elisabeth , van der Kallen Carla J. H. , Schalkwijk Casper G. , Stehouwer Coen D. A. , van Greevenbroek Marleen M. J. 
Published: January 2020

AbstractAims/hypothesisReactive α-dicarbonyl compounds are major precursors of AGEs and may lead to glycation of circulating and/or cell-associated complement regulators. Glycation of complement regulatory proteins can influence their capacity to inhibit complement activation. We investigated, in a human cohort, whether greater dicarbonyl stress was associated with more complement activation.MethodsCirculating concentrations of dicarbonyl stress markers, i.e. α-dicarbonyls (methylglyoxal [MGO], glyoxal [GO] and 3-deoxyglucosone [3-DG]), and free AGEs (Nε-(carboxymethyl)lysine [CML], Nε-(carboxyethyl)lysine [CEL] and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine [MG-H1]), and protein-bound AGEs (CML, CEL, pentosidine), as well as the complement activation products C3a and soluble C5b-9 (sC5b-9), were measured in 530 participants (59.5 ± 7.0 years [mean ± SD], 61% men) of the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study. Multiple linear regression analyses were used to investigate the associations between dicarbonyl stress (standardised) and complement activation (standardised) with adjustment of potential confounders, including age, sex, lifestyle, use of medication and markers of obesity. In addition, the associations of two potentially functional polymorphisms (rs1049346, rs2736654) in the gene encoding glyoxalase 1 (GLO1), the rate-limiting detoxifying enzyme for MGO, with C3a and sC5b-9 (all standardized) were evaluated.ResultsAfter adjustment for potential confounders, plasma concentration of the dicarbonyl GO was inversely associated with sC5b-9 (β−0.12 [95% CI –0.21, −0.02]) and the protein-bound AGE CEL was inversely associated with C3a (−0.17 [−0.25, −0.08]). In contrast, the protein-bound AGE pentosidine was positively associated with sC5b-9 (0.15 [0.05, 0.24]). No associations were observed for other α-dicarbonyls and other free or protein-bound AGEs with C3a or sC5b-9. Individuals with the AG and AA genotype of rs1049346 had, on average, 0.32 and 0.40 SD lower plasma concentrations of sC5b-9 than those with the GG genotype, while concentrations of C3a did not differ significantly between rs1049346 genotypes.GLO1rs2736654 was not associated with either C3a or sC5b-9.Conclusions/interpretationPlasma concentrations of dicarbonyl stress markers showed distinct associations with complement activation products: some of them were inversely associated with either C3a or sC5b-9, while protein-bound pentosidine was consistently and positively associated with sC5b-9. This suggests different biological relationships of individual dicarbonyl stress markers with complement activation.
A multi-center, retrospective, preliminary observational study to assess the safety of BellaGel® after augmentation mammaplasty
Authors: Choi Moon Seop , Chang Jae Hoon , Seul Chul Hwan 
Published: January 2020

Abstract
Background
BellaGel® is the only cohesive silicone gel-filled breast implant from a Korean manufacturer, and it was first developed in 2005. It was approved by the CE in 2008, thus becoming the first Asian breast implant available in the EU. We conducted this study to assess the safety of BellaGel® in patients receiving augmentation mammaplasty.

Methods
We evaluated a consecutive series of 239 patients (478 breasts) who received esthetic augmentation mammaplasty using the BellaGel® (round smooth, round textured, round nanotextured, and anatomical textured types of implant) (HansBiomed Co. Ltd., Seoul, Korea) at three clinics in Korea (JW Plastic Surgery Center, BS The Body Plastic Surgery Clinic and Grace Plastic Surgery Clinic) during a period from December 1, 2015 to January 31, 2018.

Results
A total of 239 patients with a mean age of 33.1 ± 8.5 years old were followed up during a mean period of 399.58 ± 232.71 days, where there were no cases of capsular contracture in our clinical series of the patients. Other complications include one case (0.4%) of seroma, three cases (1.3%) of hematoma, and one case (0.4%) of infection. Moreover, there were no significant differences in the cumulative incidences of complications between the four types of the BellaGel® (χ2 = 2.322, df = 3, P = 0.508). Furthermore, the cumulative Kaplan-Meier survival rate was estimated at 0.979 (95% CI 0.961–0.997).

Conclusions
Our results indicate that the BellaGel® is such a safe breast implant that surgeons might consider using it for esthetic augmentation mammaplasty.
Level of evidence: Level III, risk/prognostic study.