bluuebunny/crossref_metadata_2025_split huggingface dataset:
1324Reprocessing of electrophysiology catheters in EHRA countries. An EHRA Young EP survey
Authors: Duncker D , Svetlosak M , Guerra F , Nagy K V , Vanduynhoven P , Mikhaylov E , Kosiuk J 
Published: June 2020

Abstract

Introduction
Reprocessing of electrophysiology (EP) catheters in daily routine varies through countries and may depend on national laws, catheter (cath.) models or supplier. Data on reprocessing of EP materials is sparse and remains a matter of controversy. The aim of this study is to collect data on reprocessing usage through EHRA countries.

Methods and results
A structured online questionnaire comprising 27 questions was distributed among electrophysiologists in EHRA countries. Two-hundred-and-two participants from 34 countries completed the survey (161 males, 36.8 ± 5.8 years old). Overall, 111 (55%) of respondents currently use reprocessed materials and 30 (15%) have used them in the past. Cables, diagnostic cath. with deflectable curve and diagnostic cath. with fixed curve were the most frequently reprocessed materials (87%, 80% and 78% respondents, respectively). Maximum number of times (median) a cath. was usually reprocessed was 6 for diagnostic cath. and 5 for ablation cath. Among potential benefits of reprocessing, cost reduction for the providing hospital (65%), cost reduction for the health provider (42%) and making EP procedure available for more patients (42%) were most frequently reported. Respondents reported a need to change the reprocessed material due to its insufficient functionality in around 15% of cases. They were also concerned about the quality of the reprocessed material (58%), contamination issues (52%) and loss of precision (47%). Nineteen (17%) users of reprocessed EP material reported at least one complication potentially related to the reprocessing during their whole reprocessing experience. Sixty-six (73%) respondents who did not use reprocessed EP material would consider using it in the future.

Conclusions
Reprocessing of EP material is heterogeneously managed among the EHRA countries, as wide differences are present in terms of national and local regulations, clinical practice and technical aspects. Nonetheless, the current data show that European electrophysiologists consider the use of reprocessed EP material as generally safe and cost-effective.
P1101Is there any link between vitamin D deficiency and vasovagal syncope?
Authors: Usalp S , Kemal H , Yuksek U , Yaman B , Gunsel A , Edebal O , Akpinar O , Cerit L , Duygu H 
Published: June 2020

Abstract

Background
This study aimed to investigate serum 25[OH]D levels between patients with vasovagal syncope(VVS) diagnosed by head-up tilt table test (HUTT) and patients who do not develop syncope during the test.

Methods
Sixty-eight consecutive patients [mean age 33.2 ± 14.5 years, 49 females (72.1%)] were categorized based on their HUTT results (positive vs. negative, n = 40 vs. 28).25[OH]D levels were measured by chemiluminescent microparticle immunoassay method in all patients.

Results
There was no difference between the two groups in terms of blood tests, Body Mass Index, gender, echocardiographic findings(p &gt; 0.05).Mean 25[OH]D level was lower in HUTT positive patients when compared to the HUTT negative group(p &lt; 0.05).25[OH]D levels were significantly lower between patients over the age 25 in two groups (mean level 17.9 ± 7.3 vs 26.3 ± 8.5, respectively,p &lt; 0.005).(Table 1)

Conclusion
We found that patients diagnosed VVS by HUTT test had lower 25[OH]D levels.Measurement of vitamin D level may be an important factor in VVS patients.
Table 1 Head-up Tilt Testing positive (n = 40) negative (n = 28) p value Age (years) 33.2 ± 13.7 33.3 ± 15.9 0.973 Female gender (%) 31 (77.5) 18(64.3) 0.232 BMI (kg/m2) 23.4 ± 3.1 23.0 ± 2.6 0,596 EF (%) 59.2 ± 1.6 59.1 ± 1.3 0.357 LA (mm) 34 ± 2.4 33 ± 2.7 0.715 RA (mm) 32 ± 2.5 31 ± 2.7 0.141 Vitamin D (ng/mL) 16.5 ± 6.6 23.9 ± 9.5 0.001 Vitamin B12 (pg/mL) 355.1 ± 124.6 378 ± 87.0 0.367 TSH (mIU/L) 1.8 ± 0.8 1.7 ± 0.9 0.367 Glucose (mg/dL) 87.0 ± 7.4 90.5 ± 8.1 0.076 Creatinine (mg/dL) 0.6 ± 0.1 0.7 ± 0.1 0..55 Sodium (mmol/L) 139.8 ± 2.0 139.7 ± 2.5 0.931 Potassium (mmol/L) 4.1 ± 0.3 4.1 ± 0.2 0.674 Calcium (mg/dL) 8.9 ± 0.9 8.9 ± 1.1 0.476 Wbc (x103/uL) 7.3 ± 1.6 6.9 ± 1.6 0.339 Hb (g/dL) 13.3 ± 1.3 13.5 ± 1.8 0.664 Age (years) Vitamin D level Vitamin D level 0.132 ≤ 25 (n = 31) 14.8 ± 5.5 21.2 ± 10.2 0.057 &gt; 25 (n = 37) 17.9 ± 7.3 26.3 ± 8.5 0.005 Patients characteristics of Head-up Tilt Testing positive and negative group
P1496Impact of electrical reverse remodeling by cardiac resynchronization therapy on adverse cardiac events in patients of heart failure with reduced ejection fraction
Authors: Kobayashi H , Okada A , Tabata H , Shoin W , Okano T , Yoshie K , Shoda M , Kuwahara K 
Published: June 2020

Abstract

Background
Recently, structural reverse remodeling (SRR) and electrical reverse remodeling (ERR) after cardiac resynchronization therapy (CRT) have been reported in patients of heart failure with reduced ejection fraction (HFrEF). However the relationship between ERR and subsequent adverse cardiac events is still unknown. We aimed to elucidate the impact of ERR after CRT on the occurrence of heart failure events and ventricular arrhythmias.

Methods
A total of 36 HFrEF patients who underwent newly CRT implantation were investigated retrospectively. The intrinsic QRS duration (iQRSd) had been recorded before and more than 6 months after CRT implantation. Biventricular pacing was temporarily turned off during measurement of iQRSd. ERR was defined as positive shortening of iQRSd and SRR was defined as reduction of left ventricular end systolic volume by more than 15% after CRT implantation. The primary endpoint was a composite of all cause death, heart failure hospitalizations and ventricular tachyarrhythmia events.

Results
ERR was observed in 17 patients (47.2%) and SRR in 22 patients (61.1%). The group with ERR included more patients with lower NYHA class prior to CRT and patients with SRR. The primary endpoint was observed in 15 patients (51.4 %) for a median of 181 [63, 367] days during follow-up. Kaplan-Meier analysis revealed that the group without ERR was poor prognosis compared with the group with ERR (p = 0.022, Log-rank test).

Conclusion
Patients of HFrEF with ERR after CRT may have fewer adverse cardiac events such as worsening heart failure or ventricular arrhythmia events from this short-term study.
Abstract Figure. Adverse cardiac events and ERR
P1453Feasibility and safety of a minimal fluoroscopy approach, aiming to ALARA strategy, compared to conventional approach in a population of adult patients with high risk accessory pathways
Authors: Buia V , Bastian D , Walascheck J , Rordorf R , Petracci B , Vicentini A , Muca M , Savastano S , Sanzo A , Rittger H , Vitali Serdoz L 
Published: June 2020

Abstract

Funding Acknowledgements
None

Introduction
Catheter ablation is the treatment of choice for accessory pathways (AP) in high risk patients.Traditionally fluoroscopy has been the primary tool for visualizing catheter position and stability, however it has been shown that 3D electro-anatomic mapping systems (3D EAMS) can significantly reduce and even eliminate fluoroscopy exposure during catheter ablation, thus reducing the stochastic risk of malignancies.

Purpose
aim of our study is to assess that an ablation strategy using 3D EAMS with limited or no fluoroscopy, rigorous set-up of the X-ray equipment and intracardiac or transesofageal (TEE)echo to guide the transeptal puncture has the same degree of safety and effectiveness in ablating APs as the conventional fluoroscopic approach (CFA), and can be adopted for both right and left sided APs in the adult population,reducing the effective doses.

Methods
our retrospective analysis included 60 consecutive-prospective enrolled adult patients with high-risk APs treated either with a CFA in IRCCS Policlinico San Matteo (Pavia) or with a 3 EAMS guided minimally fluoroscopic approach (MFA) in Klinikum Fuerth (Fuerth) between 01/2016 and 09/2019.

Results
the 2 groups were homogeneous and comparable for age,sex and numbers of right/left-sided SP. In the MFA group we demonstrated the safety and feasibility of a principally 3D EAMS guided ablation approach, having the same rate of acute ablation success,while obtaining a statistically different fluoroscopy exposure time (P &lt;0.000), dosis-area product (P&lt; 0.000) and effective dosis (P &lt; 0.000) compared to the CFA group. (Table)

Conclusions
the radiation exposure risk is cumulative and lifelong. We demonstrated that to adopt a MFA increasing the use of 3D EAMS, fluoro optminization and of TEE guided transeptal is feasible and safe forAPs ablation in adults, which will benefit of a lower or even absent fluoroscopic exposure while having the same degree of safety and efficacy of a CFA.
Results Conventional Fluoroscopic Approach Minimal fluoroscopic approach P Patient (N) 31 29 n.s. Right AP 10 6 n.s. Left AP 21 23 n.s. Acute Efficacy 27 (87%) 28 (96.6%) n.s. Complication 1 (3%) 0 n.s. Fluoroscopy Time (min) 43+/-32 1.8+/-3.8 0.000 DAP (microGray*m2) 15252+/-11132 56.8+/-135.6 0.000 Effective Dosis (mSv) 30.35+/-27.7 0.09+/-0.28 0.000 AP, accessory pathway; min, minutes.
P992Socio-demographic inequalities in the uptake of screening for atrial fibrillation within the STROKESTOP II study: support for decentralised screening
Authors: Kemp Gudmundsdottir K , Holmen A , Fredriksson T , Svennberg E , Al-Khalili F , Engdahl J , Stromberg U 
Published: June 2020

Abstract

Funding Acknowledgements
Roche Diagnostics, The Swedish Heart and Lung Foundation, Carl Bennett AB

Background
To prevent stroke as a first clinical manifestation of atrial fibrillation (AF), screening for AF has been suggested. In the STROKESTOP I (SSI) study, participation was significantly influenced by socio-demographic and geographic factors.

Purpose
The main aim was to improve participation in the STROKESTOP II (SSII) study, especially aiming at socioeconomically weaker groups.

Methods
As in the SSI study, in the SSII study all 75/76-year-olds were randomised 1:1 to either a screening arm or a control arm. The individuals in the screening arm were invited to an AF-screening-program. Two screening sites were added in the SSII study, located closer to low-income neighbourhoods with very low participation rates in the SSI study. Information on each invitee’s residential parish was used for a geo-mapping analysis of the geographical disparities in participation. Individual data for the participants and non-participants were obtained with respect to the following socioeconomic variables: educational level, disposable income, immigrant and marital status. Geographic and socio-demographic disparities in the uptake of the SS2 study were analysed and the results compared between the STROKESTOP trials.

Results
Overall, higher participation was observed in those with higher education, high income as well as among non-immigrants and married individuals. Participation between the SSI and SSII improved significantly in the two areas where additional screening sites were introduced. These improvements were generally significant, in each population group according to the socio-demographic characteristics.

Conclusion
Decentralisation of the screening sites in an AF-screening-program had significant impact on the screening uptake. Addition of local screening sites in areas with a very low uptake may have a beneficial impact on the uptake across the full spectrum of socio-demographic groups
Abstract Figure. Participation map
1268A family with a novel variant in the SLC4A3 gene leading to short QT phenotype - the importance of whole-exome-sequencing and cascade screening
Authors: Kovacs B , Graf U , Magyar I , Baehr L , Maspoli A , Firat D , Berger W , Saguner A M 
Published: June 2020

Abstract

Funding Acknowledgements
none

Introduction
Short QT syndrome (SQTS) is a rare, autosomal dominant disease causing ventricular fibrillation and sudden cardiac death. Genetic testing is recommended according to current guidelines. Mutations in KCNQ1, KCNH2, KCNJ2 and more recently SLC4A3 genes have been implicated in SQTS. These genes encode potassium channel subunits and a bicarbonate transporter regulating intracellular pH. A dominant mutation in this transporter can lead to increased intracellular pH and shortened action potential.

Purpose
We present a family with a short QT phenotype and recurrent syncope in whom a novel genetic variant was detected by whole-exome sequencing (WES), confirmed by cascade screening.

Methods
We performed a thorough work-up of the index patient including medical history, physical examination, 12-lead ECG, echocardiography, stress testing, coronary angiography, flecainide challenge, and genetic testing with NGS. QTc was determined using Bazett’s formula. CS of all 1° and two 2° relatives was performed.

Results
The ECG of the index patient showed a QTc of 340ms and characteristics compatible with a SQTS (figure). Clinical work-up was unremarkable. A first genetic search with next generation sequencing focusing on genes that have been previously involved in the pathogenesis of channelopathies detected a rare known heterozygous missense variant in the KCNH2 gene (Arg328Cys, frequency 0.053%), which was predicted to be pathogenic according to various prediction algorithms (Polyphen, SIFT, Align GVGD, mutation taster). ECG screening of all asymptomatic first-degree family members identified a SQT phenotype in the mother (QTc 355ms), but not in the father (QTc 380ms) and sister (410ms). The KCNH2 variant was found in the father and sister but not the affected mother, which excludes this variant as the causative mutation in this family. Therefore, reanalysis of WES data was performed and revealed a novel heterozygous missense variant p.(Arg370Cys) in the SLC4A3 gene, recently associated with SQTS. A mutation in this gene at the same position has been previously reported in SQTS. The p.(Arg370Cys) mutation was found in the mother but not in the unaffected father or sister. Furthermore the mutation was present in two affected maternal uncles (QTc 319ms and 342ms) supporting the assumption that this was the causative mutation in this family.

Conclusions
A novel genetic variant in the SLC4A3 gene leading to sQT phenotype could be detected using WES and cascade screening. Predictive bioinformatic algorithms to assess the pathogenicity of missense variants are of limited relevance, but genetic analysis of additional unaffected and affected family members may be instrumental to identify pathogenic DNA sequence variations.
Abstract Figure. Pedigree and ECGs of the family
P1096Cardioneuroablation changes the type of vaso-vagal response in patients with asystolic reflex syncope
Authors: Piotrowski R , Zuk A , Baran J , Sikorska A , Krynski T , Kulakowski P 
Published: June 2020

Abstract

Funding Acknowledgements
Centre of Postgraduate Medical Education No. 501-1-10-14-19
Background. Cardioneuroablation (CNA) - ablation of ganglionated plexi (GP) to eliminate or reduce parasympathetic overactivity, has been recently proposed as a new therapeutic method in patients with vaso-vagal syncope (VVS) due to cardioinhibitory or mixed mechanism.
Purpose. To assess the impact of CNA on the type of VV response during tilt testing (TT).
Methods. The study group consisted of the first 20 patients (7 males, mean age 38 ± 9 – year – old) enrolled in the ongoing prospective Roman study (NCT 03903744). All patients had a history of ECG documented syncope due to asystole and confirmed asystolic form of VVS at baseline TT. CNA was performed using electroanatomical system Carto 3 and radiofrequency applications delivered in the right and left atrium at the right anterior GP and right inferior GP sites. The second TT was performed three months later. Resting heart rate (HR) and heart rate variability parameter (SDDN) were also assessed.
Results. At baseline TT, nineteen patients had cardioinhibitory syncope (asystole ranging from 3 to 60 s) (sinus node arrest – 17 patients, A-V block – 2 patients) and 1 had mixed form of VVS (asystole lasting 3 s preceded by hypotension). During three-month follow-up no syncopal episodes were noted. At the 3-month TT, 6 (30 %) patients had no syncope whereas the remaining 13 (65 %) had syncope – twelve (60 %) due to vasodepressor mechanism and only one (5 %) due to asystole - as before CNA. One patient did not have TT because of pregnancy. Mean resting HR after CNA was significantly faster and SDNN significantly lower than before the procedure (82 ± 9 vs 69 ± 11 beats/min, p = 0.0004 and 74 ± 22 vs 143 ± 40 ms, p = 0.00003, respectively) and these changes were was similar in those who fainted during second TT and those who did not (82 ± 11 vs 81 ± 4 beats/min, p = NS and (75 ± 2 vs 77 ± 18 ms, p = NS, respectively).
Conclusions. CNA profoundly affects the type of VV reaction causing normalization of the response to tilting or changing cardiodepression to vasodepression. These effects are also depicted by changes in HR and heart rate variability. Elimination of TT-induced reflex asystole may prevent clinical recurrences of syncope during short-term follow-up. These findings encourage to conduct further studies involving CNA since this method appears to be effective and obviates the need for pacemaker implantation in young people with reflex asystolic syncope.
P1025Incidence and characteristics of pulmonary vein reconduction after second-generation cryoballoon-based pulmonary vein isolation: Impact of different ablation strategies
Authors: Heeger C H , Rexha E R , Maack S M , Rottner L , Fink T , Mathew S M , Maurer T M , Lemes C L , Rillig A R , Wohlmuth P W , Reissmann B R , Tilz R R , Ouyang F O , Kuck K H K , Metzner A M 
Published: June 2020

Abstract

Funding Acknowledgements
none

Introduction
The second-generation CB (CB2, Arctic Front Advance, Medtronic Inc., Minneapolis, USA) has demonstrated high procedural success rates, relatively short procedure times, high durability of PVI and convincing long-term clinical success rates. Nevertheless, data on the impact of different ablations protocols on durability after CB2 based PVI is limited.

Purpose
We aimed at comparing durability of pulmonary vein isolation (PVI) following three different ablation strategies utilizing the second-generation cryoballoon (CB2) in patients with recurrence of atrial fibrillation (AF) or atrial tachycardia (AT) undergoing repeat procedures.

Methods
In 192 patients a total of 751 PVs were identified. All PVs (751/751, 100%) were successfully isolated during index PVI. Thirty-one out of 192 (16%) patients were treated with a bonus-freeze protocol (group 1), 67/192 (35%) patients with a no bonus-freeze protocol (group 2), and 94/192 (49%) patients with a "time-to-effect"-guided ablation protocol without bonus freezes (group 3).

Results
Persistent PVI was documented in 419/751 (55.8%) PVs, and in 41/192 (21%) patients all PVs were persistently isolated. The number of patients with all PVs being persistently isolated was not significant between the groups (p = 0.594). The total rate of PV reconnection was not significantly different between the three groups (p = 0.134) and the comparison of individual PVs revealed also no differences for different ablation protocols (p-values for RSPV: 0.424, RIPV: 0.541, LSPV: 0.788, LIPV: 0.346, LCPV: 0.865). The procedure times were significantly reduced in non-bonus freeze ablation protocols and/or when applying individualized application times (group 1: 123.4 ± 31.5min, group 2: 112.9 ± 39.8 min, group 3: 86.67 ± 28.4 min, p &lt;0.001).

Conclusions
A considerably high rate of persistent PVI was demonstrated in patients after index CB2-based PVI. No differences for durable PVI were detected for different ablation protocols. Therefore, individualized ablation protocols might be a beneficial ablation strategy during CB2-based PVI.
P1488Autonomic nervous system optimized cardiac resynchronization therapy
Authors: Thong T , Tran-Tat D , Nguyen-Duy T 
Published: June 2020

Abstract
Introduction. Traditional Cardiac Resynchronization Therapy, CRT, relies on bi-ventricular, bi-V, pacing. For left bundle branch block, LBBB, patients with good atrial-right ventricular conduction, A-RVc, alternatives have been proposed that use left-ventricular only pacing, LVoP, with adaptive atrio-ventricular delay, AVD, that is updated every minute from A-RVc measurements. The key advantage is extended device longevity since the RV pacing pulse is not emitted.
Purpose. In this paper we present a CRT alternative using fixed AVD LVoP + RV sense trigger (an LV pulse is triggered when an RV depolarization is sensed), RVsT, that can be used with LBBB patients with good A-RVc. Intrinsic RV depolarization is used. The longevity of the device is expected to approach that of a dual chamber device since AVD adaption is not needed.
Method. 5 CRT patients with LBBB and good A-RVc, previously programmed to bi-V pacing, were reprogrammed to fixed AVD LVoP + RVsT. The devices are standard CRT pacemakers, CRT-P, with RVsT. They are normally operated in LVoP mode. In response to atrial tachycardia, mode switching to bi-V will be required. So, 3 chamber devices are still required.
Results. Nightly at about 02:00 the CRT-P collects Ax-Vs (Ax = As & Ap) statistics for 35 consecutive heart cycles with AVD of 300 ms, while the patient is asleep. A typical plot of these timing statistics at the time of reprogramming to LVoP is shown in Fig. 1. After a self-training period of 2 weeks to 9 months, these statistics coalesce in a narrow range of values, 20 ms wide, as illustrated in Fig. 2 for our super responder (2 weeks). This 20 ms wide pattern persisted for the next 9 months. In the case of the index patient this lasted 3+ years. This persistent A-RVc pattern across all 5 patient can only be explained by a tight dromotropic control by the Autonomic Nervous System, ANS.
Fig. 3 illustrates RVsT. As the RVs arrives earlier than the LVp, there is no longer synchronicity improvement since the LVp now follows the RVs immediately. In Fig. 4, we see long periods with high %RVs associated with high heart rates. Increased hemodynamic demand can only be met by increased contractility. Thus inotropic modulation by the ANS is now active and effective.
The patients were put on remote monitoring with nightly follow-ups. Over a period of 6.5 months RVs (pre LVp) statistics were collected. A daily median of 11% was reported for this patient. On a particular day, it can be as high as 50%. Dromotropic action to pull in the RVs cannot be explained without concurrent inotropic modulation.
Conclusions. Traditional CRT leads to ineffective ANS modulation due to bi-V pacing for &gt;95-98% of the cycles. In our 5 patients the fixed AVD LVoP + RVsT program has allowed nervous system remodeling and the ANS is back in control of hemodynamics. Thus we have ANS optimized CRT! It is an attractive CRT alternative for LBBB patients with good A-RVc since device longevity is also improved.
Abstract Figure. Fixed delay LV-only + RVs trigger