bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of psychogenic nonepileptic seizures (PNES) using video telehealth
Authors: LaFrance William Curt , Ho Wing Lam Natalie , Bhatla Alana , Baird Grayson L. , Altalib Hamada Hamid , Godleski Linda 
Published: October 2020

AbstractObjectivePrevious studies have shown the effectiveness of manual‐based treatment for psychogenic nonepileptic seizures (PNES), but access to mental health care still remains a problem, especially for patients living in areas without medical professionals who treat conversion disorder. Thus, we evaluated patients treated with cognitive behavioral therapy–informed psychotherapy for seizures with clinical video telehealth (CVT). We evaluated neuropsychiatric and seizure treatment outcomes in veterans diagnosed with PNES seen remotely via telehealth. We hypothesized that seizures and comorbidities will improve with treatment.MethodsThis was a single‐arm, prospective, observational, cohort, consecutive outpatient study. Patients with video‐electroencephalography–confirmed PNES (n = 32) documented their seizure counts daily and comorbid symptoms prospectively over the course of treatment. Treatment was provided using a 12‐session manual‐based psychotherapy treatment given once per week, via CVT with a clinician at the Providence Veterans Affairs Medical Center.ResultsThe primary outcome, seizure reduction, was 46% (P = .0001) per month over the course of treatment. Patients also showed significant improvements in global functioning (Global Assessment of Functioning, P = < .0001), quality of life (Quality of Life in Epilepsy Inventory–31, P = .0088), and health status scales (Short Form 36 Health Survey, P < .05), and reductions in both depression (Beck Depression Inventory–II, P = .0028) and anxiety (Beck Anxiety Inventory, P = .0013) scores.SignificancePatients with PNES treated remotely with manual‐based seizure therapy decreased seizure frequency and comorbid symptoms and improved functioning using telehealth. These results suggest that psychotherapy via telehealth for PNES is a viable option for patients across the nation, eliminating one of the many barriers of access to mental health care.
Teaching animal behavior online: A primer for the pandemic and beyond
Authors: Hughes Melissa , Bertram Susan M. , Young Anna M. , Merry Justin W. , Kolluru Gita R. , Dunlap Aimee S. , Danielson‐Francois Anne , Weiss Stacey 
Published: October 2020

AbstractBehavior courses face numerous challenges when moving to an online environment, as has been made necessary by the COVID‐19 pandemic. These challenges occur largely because behavior courses, like most organismal biology courses, often stress experiential learning through laboratories that involve live animals, as well as a lecture component that emphasizes formative assessment, discussion, and critical thinking. Although online behavior courses may be remote, they can still be interactive and social, and designed with inclusive pedagogy. Here, we discuss some of the key decisions that instructors should consider, provide recommendations, and point out new opportunities for student learning that stem directly from the move to online instruction. Specific topics include challenges related to generating an inclusive and engaging online learning environment, synchronous versus asynchronous formats, assignments that enhance student learning, testing format and execution, grade schemes, design of laboratory experiences including opportunities for community science, design of synthetic student projects, and workload balance for students and instructors. We designed this primer both for animal behavior instructors who need to quickly transition to online teaching in the midst of a pandemic, and for those facing such transitions in upcoming terms. Much of the manuscript's content should also be of general interest and value to instructors from all areas of organismal biology who are attempting to quickly transition to online teaching.
Anti‐tumor necrosis factor drug responses and skin‐blood DNA methylation age: Relationships in moderate‐to‐severe psoriasis
Authors: Nwanaji‐Enwerem Jamaji C. , Nwanaji‐Enwerem Ugoji , Baccarelli Andrea A. , Williams Ramone F. , Colicino Elena 
Published: October 2020

AbstractStudies have examined the utility of DNA methylation as a biomarker of psoriasis treatment responses, but investigations of treatment responses with Skin‐Blood DNA methylation age (SkinBloodAge)—a methylation‐based measure of health designed using skin tissues—are lacking. Using a HumanMethylation450 BeadChip blood DNA methylation data set from 70 white patients who presented with moderate‐to‐severe plaque psoriasis and were treated with anti‐tumor necrosis factor (TNF) agents in Madrid, Spain, we examined the cross‐sectional relationships of SkinBloodAge with anti‐TNF treatment responses. Partial responders had a 7.2‐year higher mean SkinBloodAge than excellent responders (P = .03). In linear regression models adjusted for chronological age, sex and anti‐TNF agents ‐ on average ‐ partial responders had a 2.65‐year higher SkinBloodAge than excellent responders (95%CI: 0.44, 4.86, P = .02). This relationship was attenuated in a sensitivity analysis adjusting for white blood cells including known T‐cell mediators of psoriasis pathophysiology (β = 1.91‐years, 95%CI: −0.50, 4.32, P = .12). Overall, our study suggests that partial responders to anti‐TNF therapy have higher SkinBloodAges when compared to excellent responders. Although these findings still need to be confirmed more broadly, they further suggest that SkinBloodAge may be a useful treatment response biomarker that can be incorporated with other blood tests before anti‐TNF therapy initiation in moderate‐to‐severe psoriasis patients.
Influence of processing parameters of selective laser melting on high‐cycle and very‐high‐cycle fatigue behaviour of Ti‐6Al‐4V
Authors: Du Leiming , Qian Guian , Zheng Liang , Hong Youshi 
Published: October 2020

AbstractOrthogonal experiment design together with the analysis of variance was used to examine the processing parameters (laser power, scan speed, layer thickness and hatch spacing) of selective laser melting (SLM) for superior properties of SLM parts, in which nine groups of specimens of Ti‐6Al‐4V were fabricated. The results clarify that the influence sequence of individual parameter on the porosity is laser power > hatch spacing > layer thickness > scan speed. Ultrasonic fatigue tests (20 kHz) were conducted for the SLMed specimens in high‐cycle fatigue (HCF) and very‐high‐cycle fatigue (VHCF) regimes. The S‐N data show that the fatigue strength is greatly affected by the porosity: the group with the smallest porosity percentage having the highest fatigue strength in HCF and VHCF regimes. Then, the tests on the validation group were performed to verify the optimal combination of SLM processing parameters. Moreover, the observations by scanning electron microscopy revealed that fatigue cracks initiate at lack‐of‐fusion defects in the cases of surface and internal crack initiation.
Long‐term effects of global change on occupancy and flight period of wild bees in Belgium
Authors: Duchenne François , Thébault Elisa , Michez Denis , Gérard Maxence , Devaux Céline , Rasmont Pierre , Vereecken Nicolas J. , Fontaine Colin 
Published: October 2020

AbstractGlobal change affects species by modifying their abundance, spatial distribution, and activity period. The challenge is now to identify the respective drivers of those responses and to understand how those responses combine to affect species assemblages and ecosystem functioning. Here we correlate changes in occupancy and mean flight date of 205 wild bee species in Belgium with temporal changes in temperature trend and interannual variation, agricultural intensification, and urbanization. Over the last 70 years, bee occupancy decreased on average by 33%, most likely because of agricultural intensification, and flight period of bees advanced on average by 4 days, most likely because of interannual temperature changes. Those responses resulted in a synergistic effect because species which increased in occupancy tend to be those that have shifted their phenologies earlier in the season. This leads to an overall advancement and shortening of the pollination season by 9 and 15 days respectively, with lower species richness and abundance compared to historical pollinator assemblages, except at the early start of the season. Our results thus suggest a strong decline in pollination function and services.
Analysis of green total factor productivity trend and its determinants for the countries along silk roads
Authors: Peng Yuanxin , Chen Zhuo , Xu Juanzhi , Lee Jay 
Published: October 2020

AbstractIn coping with increasing energy consumption and the consequential environmental pollution, green development is becoming an important part of social development. Since the inauguration of China’s Silk Road Economic Belt Initiative (BRI), economic cooperation between China and other countries along BRI has seen much growth. Therefore, it is of great significance to study the levels of green total factor productivity (GTFP) of the countries in the Silk Roads Economic Belt (B&R) and examine how these levels vary spatially and evolve temporally. In this paper, a panel regression analysis with DEA windows is used to study the spatiotemporal trends of the levels of GTFP. The results are: (1) The B&R countries have seen an increase in their overall levels of GTFP over time; (2) There are regional differences in the levels of GTFP, with higher efficiency in Western Asia and Central and Eastern Europe, and lower efficiency in Southeast and Central Asia; (3) The analysis of GTFP for countries in these regions shows that the efficiencies of most countries have been improving, with that of only a few countries have been decreasing; (4) By using regression analysis, we find that variables such as import, export, industrial structure, and urban affect the B&R countries with growing GTFP.
A split face randomized controlled trial comparing 1,064 nm Q‐switched Nd‐YAG laser and modified Kligman’s formulation in patients with melasma in darker skin
Authors: Dev Tanvi , Sreenivas Vishnubhatla , Sharma Vinod K. , Sahni Kanika , Bhari Neetu , Sethuraman Gomathy 
Published: October 2020

AbstractBackgroundNo randomized studies compared the efficacy and safety of modified Kligman’s triple combination (TC) with 1,064 nm Q‐switched Nd‐YAG laser (QSNYL) in melasma in darker skin.ObjectivesTo compare the efficacy and safety of QSNYL and TC in the treatment of melasma in Fitzpatrick skin types IV and V.MethodsIn this split face randomized controlled trial, participants' cheeks were randomized to receive either weekly QSNYL (group A) or daily TC (group B) for 12 weeks, followed by 12 weeks of follow‐up.ResultsTwenty‐eight patients completed the intervention, and 21 of them completed follow‐up. We found a significant but modest reduction in mean melanin index, modified Melasma Area Severity Index (MASI), and photographic and patient’s assessment in both modalities (P < 0.01). No significant differences were detected between the groups. All patients had reappearance of pigmentation by the end of follow‐up. Adverse reactions were significantly more in group B (P < 0.001).LimitationThe desired sample size could not be achieved.Conclusion and RelevenceNo statistically significant differences were observed between QSNYL and TC as monotherapy in melasma. Reappearance of melasma is inevitable after stopping treatment.
Art & Archaeology: Uncomfortable Archival Landscapes
Authors: Wall Gina , Hale Alex 
Published: October 2020

AbstractThis paper conceptualises practice in the space between and beyond Art & Archaeology as a zone where disciplinary certainties and known practices are unsettled, expanded and re‐cast. We will outline our current thinking about heritage landscapes as places and temporalities for engagement in the practice of what Henk Slager calls the para‐archive. For us, landscape functions as a kind of living archive, however, following Jacques Derrida, we are sceptical of the privileged relation between archive, law and authority. Therefore, in this paper we will think through our interdisciplinary research in the context of the development of creative para‐archives, which facilitate new, affective ways of thinking and making by bringing together the previously unimagined. Responding to the challenge of the SARS‐CoV‐2 discomfort zone, we seek to surface creative practices, activate archival disruptions and expand pedagogical approaches to the articulation of uncomfortable archival landscapes. The pandemic has brought into sharp focus the need to re‐conceptualise visions of space, experiences of place and archival practices. During a virtual fieldtrip students accessed a range of materials from Scotland’s National Record of the Historic Environment. We aimed to enable the co‐design and co‐production of a virtual fieldtrip, followed by discussions about our collective conceptualisations of landscapes of discomfort. The archaeological fieldwork in the virtual realm provides a context for students to engage in desirology as a catalyst for deranging, re‐associating and re‐imagining the archive in creative ways.
Is contextual animation needed in multimedia learning games for children? An eye tracker study
Authors: Javora Ondřej , Hannemann Tereza , Volná Kristina , Děchtěrenko Filip , Tetourová Tereza , Stárková Tereza , Brom Cyril 
Published: October 2020

AbstractThe present study investigates affective‐motivational, attention, and learning effects of unexplored emotional design manipulation: Contextual animation (animation of contextual elements) in multimedia learning game (MLGs) for children. Participants (N = 134; Mage = 9.25; Grades 3 and 4) learned either from an experimental version of the MLG with a high amount of contextual animation or from an identical MLG with no contextual animation (control). Children strongly preferred (χ2 = 87.04, p < .001) and found the experimental version more attractive (p < .001, d = −1.11). No significant differences in overall enjoyment and learning outcomes were found. Attention differences, measured by dwell times and fixation durations, were small and reached only borderline significance (p = .035; d = −0.39). The implication is that contextual animation in MLG for children increases such instructional materials' attractiveness without compromising cognitive processes needed for learning; however, it does not lead to their higher instructional efficiency.
Relationship between resting heart rate and incident heart failure in patients with hypertension: The Kailuan Cohort Study in China
Authors: Zhao MaoXiang , Chen Yanming , Wang Miao , Wang Chi , Yao Siyu , Li Yao , Zhang Sijin , Yun Cuijuan , Wu Shouling , Xue Hao 
Published: October 2020

AbstractAn elevated heart rate increases the risk of cardiovascular disease, but the relationship between resting heart rate (RHR) and the risk of heart failure (HF) in hypertensive patients is unclear. This study was performed to assess the relationship between elevated RHR and incident HF in hypertensive patients. In total, 16 286 hypertensive patients from the Kailuan cohort were enrolled and underwent three physical examinations. According to mean RHR based on quartile, the hypertensive patients were divided into four groups: Q1 (mean RHR ≤ 69 bpm), Q2 (69 bpm < mean RHR ≤ 74 bpm), Q3 (74 bpm < mean RHR ≤ 79 bpm), and Q4 (mean RHR > 79 bpm). The cumulative mortality rate was analyzed by using the Kaplan–Meier method, with comparisons among RHR quartiles. Cox proportional hazards regression models and restricted cubic spline models were established to evaluate the association between RHR and risk of incident HF. After adjustment for confounders, the hazard ratio (HR) for HF was 1.97(95% CI: 1.28‐3.04, P < .001) in the fourth quartile compared to the first quartile. Each 1‐standard deviation [10 (beats/min)] increase in RHR was associated with a 40% increase in the risk of incident HF. Restricted cubic spline models presented a linear relationship between RHR and incident HF. Our study suggests that elevated RHR is associated with an enhanced risk of HF in hypertensive patients.
Incidence and progression of gingival recession over 4 years: A population‐based longitudinal study
Authors: Rios Fernando S. , Costa Ricardo S. A. , Wagner Tassiane P. , Christofoli Barbara R. , Goergen Joseane , Izquierdo Cristina , Jardim Juliana J. , Maltz Marisa , Haas Alex N. 
Published: October 2020

AbstractAimTo describe changes in gingival recession (GR) at buccal and palatal sites in adults over an average follow‐up of 4 years.Materials and methodsBaseline data were obtained from a multistage probabilistic representative sample of 1023 individuals aged ≥35 years from Porto Alegre, Brazil. Buccal and palatal/lingual GR were analysed.Results402 individuals (6,862 teeth) were followed. At baseline, 3,356 (48.9%) teeth did not have GR at the buccal site and 1206 developed the condition overtime (incidence =35.9%; 95% CI 32.6‐38.9). Percentage of incident teeth was higher among individuals with (42.3%) than those without (29.5%) periodontitis stages III/IV. Also, 38.5% of teeth with proximal attachment loss at follow‐up had incident GR compared to 7.6% of those without proximal attachment loss. Incidence of palatal GR was observed in 32.5% of teeth (95% CI 29.7‐35.3). Mean buccal and palatal/lingual GR incidence was 2.11 mm and 2.33 mm, whereas buccal and palatal/lingual GR progression equalled 0.40 mm and 0.48 mm. The prevalence of GR ≥3 mm increased in individuals with (from 35.9% to 47.4%) and without (from 25.2 to 41.5%) periodontitis.ConclusionIncidence and progression of GR are high in a general urban Brazilian population of adults.
The metamorphic PT history of Precambrian Belomorian eclogites (Shirokaya Salma), Russia
Authors: Li Xiaoli , Zhang Lifei , Bader Thomas 
Published: October 2020

AbstractThis petrological study details representative well‐preserved and partly retrogressed eclogite samples from the Shirokaya Salma locality in the Belomorian Province (Russia) to resolve ambiguity in the PT evolution of one of the oldest eclogite occurrences on Earth. Based on microstructures, eclogite and granulite facies mineral assemblages comprise omphacite, garnet (interior), quartz, rutile±phengite and diopside, garnet (modified rim), plagioclase, orthopyroxene, amphibole, quartz, rutile/ilmenite±melt respectively. Omphacite and Na‐bearing diopside feature breakdown textures with multiple oriented quartz–amphibole and orthopyroxene lamellae, while diopside forms symplectite with plagioclase. Garnet often exhibits a particular compositional annulus in both major and trace elements (Y+REE). We interpret the high‐Ca and inclusion‐rich garnet (core) with outwards Grs decrease and Prp increase as relict of prograde growth. The mantle‐rim domain of garnet, containing omphacite, diopside, plagioclase and rutile formed during eclogitization. Compositionally homogeneous garnet porphyroblasts are most likely outcomes of high‐T modifications. A progressive zonation of Y+REE from core to rim in several garnets is related to resorption at high temperatures. Both geothermometric and pseudosection calculations reveal a typical orogenic clockwise trajectory for the studied eclogites, and their metamorphic PT path includes a possible pre‐eclogitic stage (M0) at <630°C, ~16–19 kbar, a peak eclogite facies stage (M1) at 19–21 kbar, 670–750°C, a granulite facies overprint (stage M2) from 14–16 kbar, 830–870°C (M2a) to 10–11 kbar, 880–910°C (M2b), and retrogression to <9–11 kbar, <650–680°C (stage M3). It agrees well with our previous estimates for other Salma eclogites with Palaeoproterozoic ages.
Information Inertia
Authors: ILLEDITSCH PHILIPP K. , GANGULI JAYANT V. , CONDIE SCOTT 
Published: October 2020

ABSTRACTWe show that aversion to risk and ambiguity leads to information inertia when investors process public news about assets. Optimal portfolios do not always depend on news that is worse than expected; hence, the equilibrium stock price does not reflect this bad news. This informational inefficiency is more severe when there is more risk and ambiguity but disappears when investors are risk‐neutral or the news is about idiosyncratic risk. Information inertia leads to news momentum (e.g., after earnings announcements) and is consistent with low household trading activity. An ambiguity premium helps explain the macro and earnings announcement premium.
Coronary artery calcium scoring: an evidence‐based guide for primary care physicians
Authors: Cheong B. Y. C. , Wilson J. M. , Spann S. J. , Pettigrew R. I. , Preventza O. A. , Muthupillai R. 
Published: October 2020

AbstractPrimary care physicians often must decide whether statin therapy would be appropriate (in addition to lifestyle modification) for managing asymptomatic individuals with borderline or intermediate risk for developing atherosclerotic cardiovascular disease (ASCVD), as assessed on the basis of traditional risk factors. In appropriate subjects, a simple, noninvasive measurement of coronary artery calcium can help clarify risk. Coronary atherosclerosis is a chronic inflammatory disease, with atherosclerotic plaque formation involving intimal inflammation and repeated cycles of erosion and fibrosis, healing and calcification. Atherosclerotic plaque formation represents the prognostic link between risk factors and future clinical events. The presence of coronary artery calcification is almost exclusively an indication of coronary artery disease, except in certain metabolic conditions. Coronary artery calcification can be detected and quantified in a matter of seconds by noncontrast electrocardiogram‐gated low‐dose X‐ray computed tomography (coronary artery calcium scoring [CACS]). Since the publication of the seminal work by Dr. Arthur Agatston in 1990, a wealth of CACS‐based prognostic data has been reported. In addition, recent guidelines from various professional societies conclude that CACS may be considered as a tool for reclassifying risk for atherosclerotic cardiovascular disease in patients otherwise assessed to have intermediate risk, so as to more accurately inform decisions about possible statin therapy in addition to lifestyle modification as primary preventive therapy. In this review, we provide an overview of CACS, from acquisition to interpretation, and summarize the scientific evidence for and the appropriate use of CACS as put forth in current clinical guidelines.