bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of IOL Power Calculated by Preoperative Biometry versus Intraoperative Wavefront Aberrometry in Thai Cataract Patients.
Authors: Khambhiphant Bharkbhum , Thanyaporn Sribenjapanon 
Published: May 2020

Abstract
Background : To find agreement between the calculated intraocular lens (IOL) power from using the SRK/T based preoperative biometry and the intraoperative wavefront aberrometry (ORA ® ) in Thai cataract patients, and to compare the accuracy of each method with the postoperative refraction results. Methods : Eyes that underwent cataract surgery with monofocal or multifocal IOL implantation were enrolled in this prospective study. All eye biometry was measured preoperatively and the ORA intraoperatively. The SRK/T suggested IOL from the preoperative biometry was chosen in all cases. The suggested power and the estimated refraction (EST) from both devices were collected. Bland Altman analysis was used to find the agreement between them. The predicted EST of implanted IOL from both devices were compared with the one-month postoperative SE. Results : The study comprised 97 eyes (79 patients). Of these, 38 eyes (39.2%) had the same suggested IOL power, 36 eyes (37.1%) were within ±0.5D, 20 eyes (20.6%) were within ±1.0D and 3 eyes were beyond ±1.0D. Bland-Altman analysis found the mean difference between IOL power calculated from both devices was 0.39 with LoA of -0.54 to 1.31. The correlation was 98.50% (95%CI 98%- 99.10%). In the same suggested IOL power group, the median difference of EST by preoperative biometry and ORA compared with one-month postoperative SE were -0.08 (95%CI: -0.08, 1.11), and -0.14 (95%CI: -0.88, 1.2), respectively. Conclusions :The ORA and preoperative biometry results were in concordance with each other. The result of preoperative biometry was more accurate than ORA in this study. Trial Registration: The clinical trial registration number: TCTR20171005001 Registration Date October 3 rd , 2017 First Enrollment November 1 st , 2017
In Vitro Virucidal Effect of Intranasally Delivered Chlorpheniramine Maleate Compound Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Authors: Ferrer Gustavo , Westover Jonna 
Published: May 2020

Abstract
Background. The initial global outbreak of the novel coronavirus disease 2019 (COVID-2019) pandemic, responsible for the severe acute respiratory syndrome 2 (SARS-CoV-2), was first reported in Wuhan, China, at the end of December 2019. COVID-19 shares similarities with the severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and it behaves similarly to influenza with a high intranasal viral load. The genome sequence of COVID-19 opened the opportunity for multiple in vitro and clinical trials, but we still do not have a clear path to treatment. Chlorpheniramine is a safe and effective antihistamine with potent antiviral activity against various strains of influenza A/B, thus suggesting that CPM has broad antiviral activity. We tested the virucidal potential of chlorpheniramine maleate (CPM) in a nasal spray composition currently in development as an anti-allergy medication.Methods. The virucidal activity of chlorpheniramine maleate was tested using viral stock of SARS-CoV-2, USA-WA1/2020 strain in Vero 76 infected cells. The end-point titer (CCID50) values were calculated with the Reed-Muench (1948) equation. Three independent replicates of each sample were tested, and the average and standard deviation were calculated. Results were compared with untreated controls by one-way ANOVA with Dunnett’s multiple comparison test in GraphPad Prism (version 8) software. Results. After 25-minutes of contact time, the nasal spray reduced the levels of the virus from 4.2 to 1.7 log10 CCID50 per 0.1 mL, a statistically significant reduction of 2.5 log10 CCID50.Conclusions. This study demonstrates the strong virucidal effect against SARS-CoV-2 of a nasal spray containing chlorpheniramine maleate. Given that CPM has broad antiviral effects against influenza, virucidal effect against SARS-CoV-2, and coadjuvant effects with hydroxychloroquine in treating multidrug-resistant malaria with minimal side effects. We propose two further studies: a randomized placebo-controlled study of intranasally delivered chlorpheniramine in patients with mild to moderate SARS-CoV-2, and a second study aiming to determine the potential antiviral and adjuvant effects of CPM plus hydroxychloroquine, versus chloroquine alone, in hospitalized patients with SARS-CoV-2.
Withdrawal Notice: Lead Optimization from Natural Ligands by In-Silico Approach for Discovering Potential Monoamine Oxidasesinhibitors (MAOIs)
Authors: Dhiman Priyanka , Malik Neelam , Khatkar Anurag 
Published: May 2020

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A Redesigned Order Entry System for Reducing Low-Value Preprocedural Cardiology Consultations: Quality-Improvement Cohort Study
Authors: Winchester David E , Cagino Leigh 
Published: May 2020

Background
Preprocedural cardiac evaluation is a common reason for outpatient cardiology visits. Many patients who are referred to cardiology clinics for preprocedural evaluation are at low risk of perioperative events and do not require any further management. Our facility treats patients over a large geographic area; avoiding low-value consultations reduces time and travel burdens for patients.

Objective
Our study objective was to assess the impact of a novel algorithm in the electronic order entry system aimed to guide clinicians toward patients who may benefit from cardiovascular referral.

Methods
We retrospectively reviewed in-person consultations and electronic consultations (e-consults) to our cardiology service before and after implementation of the novel algorithm to assess changes in patterns of care. Data were stored in a custom electronic database on internal servers.

Results
We reviewed 603 consultations to our cardiology clinic and found that 89 (14.7%) were sent for preprocedural evaluation. Of these, 39 (43.8% of preprocedural consultations) were e-consults. After implementation, we reviewed 360 consultations. The proportion of consultations for preprocedural evaluation did not decrease (n=47, 13.0%; P=.39). We observed an absolute increase of 13.6% in the proportion of consultations ordered as e-consults (27/47, 57.4%). During the postintervention period, we received no remarks, concerns, or criticisms from ordering clinicians about the process change and no reports of adverse events.

Conclusions
Implementation of an ordering algorithm to reduce low-value preprocedural cardiology evaluations did not lead to a reduction in the number of overall preprocedural cardiology consultations. The number of patients seen electronically increased, potentially improving clinic access and reducing travel burden for patients.
A Review on Signal in Pharmacovigilance
Authors: Rani Ritu , Chand Subhash , Singh Arjun , Kumar Deovrat , Devi Meena 
Published: May 2020

A safety signal is data or information that may suggest a new causal association, or contribute new information about a known association, between a medicine and an adverse event that justifies further investigation. Signals are generated from several sources such as spontaneous reports, clinical studies and the scientific literature. Signal is a potential medicine safety issues, which are derived from individual case safety reports in vigiBase. Signal detection is a cornerstone of drug development process ensuring drug safety. The early detection of Signals helps to improve patient safety and reduce economic burden due to escalating cost of medications and unwanted adverse effects associated with it. The present study is an initiative to make significant contribution towards health-care system by generating evidence based data to benefit health care professionals, consumers, pharmaceutical companies and regulatory authorities.Signal detection and signal strengthening is the most important aspect in Pharmacovigilance which plays an important role in ensuring that patients receive safe drugs. For detection of adverse drug reactions, clinical trials usually provide limited information as they are conducted under strictly controlled conditions. Some of the adverse drug reaction can be detected only after long term use in larger population and in specific patient groups due to specific concomitant medications or disease.
Assessment of In-Vivo Antioxidant Potential of Hydro-Alcoholic Extract and Ethyl Acetate Fraction of Aerva Javanica Linn. Flowering Tops
Authors: Khunteta Alok , Swarnkar Surendra K , Gupta Manish Kumar , Swarnkar Aruna , Sharma Swapnil , Paliwal Sarvesh 
Published: May 2020

Aerva javanica (Amaranthaceae) is a grey coloured woolly perennial tomentose shrub. Its traditional and folklore usage motivates further investigation on its pharmacognostic parameters and pharmacological potential. Hydro-alcoholic extract (AJCE) was prepared from flowering tops of A. javanica. In order to work further on activity guided fractions, ethyl acetate (AJEAF) fraction was prepared. Therefore, in order to establish its antioxidant potential, in-vivo effect on LPO, GSH, SOD and catalase activity was determined. For comparison, silymarin and Centella asiatica extract (CAE) were used as standard antioxidant compound/extract. Lipid peroxidation in term of MDA content expressed as nM/mg, which was 82.18 and 67.39 for AJCE with increasing doses of complete hydro-alcoholic extract (AJCE represented as AJCE-1 and AJCE-2) and 51.65 for AJEAF in contrast to 40.64 nM/mg for standard silymarin and 46.81 nM/mg for standard CAE. GSH content was determined as 3.12, 3.82 and 4.56 μg/mg wet tissue in contrast to 5.59 for standard silymarin and 4.42 for standard CAE. Superoxide scavenging was expressed as SOD U/mg wet tissue, determined as 7.26, 9.16 and 9.91 U/mg wet tissue for AJCE-1 (250 mg/kg i.p. b.w), AJCE-2 (500 mg/kg i.p. b.w), and AJEAF respectively in comparison to silymarin (10.11) and CAE (46.81 U/mg wet tissue). Catalase activity expressed as μM of H2O2 decomposed / min / mg wet tissue was determined as 0.61, 0.72 and 0.78 repectively for AJCE-1 (250 mg/kg i.p. b.w), AJCE-2 (500 mg/kg i.p. b.w), and AJEAF. Results indicated the SOD values and total antioxidant power of DEE and EAF fractions even better than standard ascorbic acid which expressed the prospective potential of fractions (DEE and EAF) against metabolic disorders.
Anti-Inflammatory Potential of Some Essential Oils: A Review
Authors: Kushwah Ritika , Gupta M K 
Published: May 2020

Inflammation and pain are common phenomena associated with a number of diseases. Inflammatory diseases result from the body’s response to tissue damage, and if the resolution is not adequate or the stimulus persists, there will be progression from acute inflammation to chronic inflammation, leading to the development of cancer and neurodegenerative and autoimmune diseases. It is necessary to search for new biologically active compounds with anti-inflammatory activity. Essential oils are complex mixtures isolated from aromatic plants which may possess antioxidant and anti-inflammatory activities. This article briefly summarizes the potential of essential oils and their compounds for the treatment of inflammatory diseases.
Evaluation of Drug Management For Tuberculosis (TB) Program At Pharmaceutical Installation Public Health Department of North Sumatra Province
Authors: Sabri April , S Wiryanto M , M Khairunnisa 
Published: May 2020

Objective: Drug management consists of planning, storing and distribution. It is one of the important duty of Public Health Department of North Sumatra Province. Poor drug management will give a negative impact on service quality. This research aimed to evaluate the management of drug programs for tuberculosis (TB) in 2017, 2018 and 2019 in the Public Health Department of North Sumatra Province. The research was conducted in July - September 2019.
Method: This research was descriptive with quantitative data obtained retrospectively and concurrently. Qualitative data were obtained through observations and interviews with informants. The data obtained were analyzed using indicators and compared with the results of the research.
Result: The result of the research showed that planning, storing and distributing drug for the TB program in the Public Health Department of North Sumatra Province had not fully met the indicator standards. This was indicated by the 6 indicators which had not met the standard, that were the accuracy of planning; planning deviations; level of drug supply; percentage of expired drug; Inventory Turn Over Ratio (ITOR); the average time of drug vacancies and the percentage of dead drug stock and 3 indicators had met the standards, which were the percentage of expired drugs, the structuring system of drugs and the matching of the number of real goods with stock.
Conclusion: the conclusion of this research is drug planning of Public Health Department of North Sumatra Province uses consumption method of previous period. Storage of drugs uses the FIFO/FEFO system. Drug distribution in the North Sumatra Provincial Health Office is based on requests from the District/City.
The Potency of Artocarpus Heterophyllus Leaf as a Facial Skin Care Ingredient in Clay Mask Formulation
Authors: Widyawati Tri , Syarifah Siti , Daulay Milahayati , Lolyta Fitri Mustanti 
Published: May 2020

Artocarpus heterophyllus (Ah), common name as nangka, has been reported to have antidiabetic, antihyperlipidemia, antimicrobial and antioxidant activity. Balinese women used its leaves for facial treatment. This study aims to evaluate its leaf potency for facial skin care. Ethanol extract of Ah (EEAh) that obtained by maceration was prepared into 3 clay mask formulations (FI: 1%, FII:3% and FIII:5%). F0 was used as control group. A total of 12 volunteers were treated with clay mask to evaluate its effect on moisture and pores size after intervention. The data were analysed using Kruskall Wallis and Mann Whitney test. The results showed that skin moisture increased after intervention (FI:3.7%; FII:4.7%;FIII:7.3%). Pores size decreased in FI (6.3%) and FII (13.4%). Statistically, there were significant different between F0-F1 (p=0.043), F0-F2 and F0-F3 (p=0.046 of each). The present study conclude that clay mask containing A. heterophyllus leaf ethanol extract have potency to be used as facial skin care.
PROTOTIPE PENGAWAS SISTEM PROTEKSI ARUS LEBIH ELEKTRONIK SECARA NIRKABEL
Authors: Anwar Arif Rahmadi , Siswanto Diky 
Published: May 2020

Relay arus lebih adalah peralatan yang sangat penting dalam sistem kelistrikan. Alat ini digunakan sebagai proteksi dari anomali atau gangguan yang dapat menimbulkan lonjakan arus dalam waktu singkat seperti ketika terjadi hubung singkat. Besarnya arus dapat merusak peralatan karena melebihi kemampuan hantar arus dari peralatan tersebut. Oleh sebab itu sistem proteksi menjadi peralatan yang wajib digunakan dalam sistem kelistrikan. Sistem proteksi ini terdiri dari beberapa peralatan seperti relay arus lebih, catu daya, baterai dan circuit breaker. Peralatan tersebut dirangkai menjadi satu sistem dengan menggunakan kabel yang rawan kendur, terlepas dan lain sebagainya yang masih belum terpantau kesiapannya setiap saat sehingga dapat berpotensi menyebabkan kegagalan sistem proteksi. Arduino uno merupakan perangkat mikrokontroler yang memiliki desain open source sehingga dapat diaplikasikan di semua peralatan elektronik. Alat ini dapat diterapkan dalam sistem proteksi untuk memantau tegangan catu daya dan baterai dengan menggunakan port analog input serta mengawasi rangkaian kabel trip coil dengan komponen optocoupler PC017 sebagai sensor input digital pada Arduino. Data yang diterima oleh Arduino uno akan dikirimkan ke online database dengan menggunakan wifi shield ESP8266, kemudian data tersebut akan ditampilkan pada aplikasi dalam ponsel Android. Dengan demikian, jika terdapat kerusakan pada salah satu peralatan tersebut maka petugas dapat segera melakukan perbaikan sebelum terjadi kegagalan sistem proteksi.
PENERAPAN MODEL DELONE DAN MCLEAN PADA SI-PMB ONLINE DARI PERSPEKTIF PENGGUNA UNTUK MENINGKATKAN KUALITAS LAYANAN
Authors: Suradi Agustinus , Windarti Mariana Windarti 
Published: May 2020

Inovasi strategi pengembangan sistem informasi perlu dikembangkan untuk mendukung kesuksesan dan kualitas layanan sistem penerimaan mahasiswa baru. Masyarakat pengguna sistem informasi penerimaan mahasiswa baru sering mengalami kesulitan ketika mencari informasi yang mereka butuhkan. Tujuan penelitian ini untuk mengidentifikasikan kesuksesan sistem informasi penerimaan mahasiswa baru (SI-PMB) online dan variabel-variabel yang mempengaruhinya. Model DeLone McLean IS Success model digunakan dalam penelitian ini, dengan komponen variabel seperti: information quality, system quality dan service quality. Analisis data yang digunakan adalah model struktural dengan alat analisis Partial Least Square (PLS) menggunakan software Smart PLS. Hasil dari penelitian diperoleh hubungan variabel Information Quality à User Satisfaction, dengan nilai t statistik 0,324, hubungan variabel Service Quality àUser Satisfaction, nilai t statistic 2,530, dan hubungan variabel System Quality à User Satisfaction, nilai t statistik 3,107, sehingga dapat disimpulkan bahwa terdapat hubungan positif dan siginifikan antara variabel system quality dan user satisfaction, terdapat hubungan positif dan siginifikan antara variabel service quality dan user satisfaction. Hubungan variabel User Satisfaction à Net Benefits, nilai t statistik 8,708 menyatakan bahwa ada hubungan positif dan siginifikan antara variabel kepuasan pengguna (user satisfaction) dengan manfaat-manfaat bersih (net benefit).
Perancangan Jaringan Femtocell Pada Jaringan 4G LTE Di Gedung Rektorat Universitas Riau
Authors: Syam Ahmad Mudhhirulhaq , Junianto Daniel , Anggreani Dyan , Suganda Ilham Ferdian , Rahayu Yusnita 
Published: May 2020

Makalah ini membahas perancangan jaringan indoor 4G LTE pada Gedung Rektor Universitas Riau menggunakan software aplikasi desktop Radiowave Propagation Simulator (RPS) 5.4. Perancangan jaringan indoor menggunakan model propagasi COST 231 Multi-Walls. Berdasarkan perhitungan area cakupan menggunakan model propagasi COST 231 Mulit-Wall yang telah dilakukan, dibutuhkan sebanyak 6 Femtocell Access Point (FAP) di setiap lantai. Analisis yang berhasil diperoleh dalam desain skenario posisi FAP pada tengah ruangan secara sejajar pada setiap lantai dengan level daya rata-rata -64,93 dBm dan SIR 6,72 dBm. Perancangan jaringan Femctocell 4G LTE menggunakan software RPS 5.4 dan model propagasi COST 231 Multi-Walls Mode dapat diterapkan ke Gedung Rektorat Universitas Riau.
Difference in the salivary pH before and after consumption of vitamin C lozenge on preclinical student of Faculty of Dentistry Universitas Padjadjaran
Authors: Sopannata Nirmala Trihasmana , Haroen Edeh Roletta , Richata Tuty Sutini 
Published: May 2020

Introduction: Vitamin C lozenge can increase pH saliva. Increasing saliva pH is cause saliva works as a buffer that can neutralize the acidity of vitamin C. The purpose of this research was to find the difference saliva pH before and after sucking vitamin C tablet. Methods: The research was carried out with quasi-experiment, using purposive sampling method and Paired t Test. This research was conducted on 30 students of the Faculty of Dentistry of Padjadjaran University, ranging 18-23 years of age. The research was carried out by measuring salivary pH before and after sucking vitamin C tablet. Results: Research result indicates that the average difference of salivary pH after sucking vitamin C tablet is 0.42 with standard deviation ±0,189. From statistic results T calc 12,282 > T table 2,05 Ho is rejected, H1 is accepted. Conclusion: The research conclusion shows that there is a significant difference on saliva pH before and after sucking vitamin C tablet lozenge on preclinical student of Faculty of Dentistry Padjadjaran University.
The difference of sweet taste threshold before and after using mouthwash containing zinc sulfate
Authors: Janarikamain Agung Ayu Dewi , Haroen Edeh Roletta , Dardjan Murnisari 
Published: May 2020

Introduction: Mouthwash containing zinc sulfate could reduce the ability of tasting sweetness temporarily. Zinc sulfate is an example of a zinc compound which is the active ingredient in mouthwash. Zinc sulfate is added in mouthwash as an antiplaque and astringent material that gives a cleaning on the mouth. This study aimed is to analized differences of sweet taste threshold changes data before and after using mouthwash containing zinc sulfate. Methods: The study was using quasi experimental study. Study sample was collage students of Dentistry Faculty of Padjadjaran University totally 30 sample ages between 18-25 years old men and women took based on purposive sampling. Murphy method was applied to measure the threshold of sweet taste perception and identification before and after using mouthwash containing zinc sulfate. Results: The result of statistically shows the average value of sweet perception threshold before and after using mouthwash containing zinc sulfate are 0.0046 M and 0.0128 M with standard deviation 0.0047 and 0.0084. Sweet identification threshold before and after using mouthwash containing zinc sulfate are 0.0164 M and 0.0248 M with standard deviation 0.0089 and 0.0082. Conclusion: There is difference of sweet taste threshold before and after using mouthwash containing zinc sulfate.