bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fam172a Mediates the Stimulation of Hypothalamic Oxytocin Neurons to Suppress Obesity‐Induced Anxiety
Authors: Wan Baocheng , Zhang Lina , Wang Xinyu , Zhang Rong , Li Lianxi , Zhang Yi , Chen Zhuo , Hu Cheng 
Published: February 2025

AbstractAnxiety disorder is the most common mental disorder worldwide. Although human studies have demonstrated a positive association between obesity and anxiety disorder, the exact mechanism linking these conditions is unclear. Interestingly, oxytocin (Oxt) neurons, predominantly expressed in the hypothalamic paraventricular nucleus (PVN), play a crucial role in both obesity and anxiety. In this study, obesity can induce anxiety‐like behavior in mice, which can be ameliorated by the activation of PVN Oxt neurons. Conversely, inhibiting PVN Oxt neurons accelerate the progression of anxiety. Moreover, the family with sequence similarity 172, member A (Fam172a), an anxiety susceptibility gene, is highly expressed in the hypothalamic PVN Oxt neuron but reduce in the PVN Oxt neuron of mice in the high‐fat diet and acute restraint stress conditions. Significantly, overexpression of Fam172a in PVN Oxt neurons improve obesity‐anxiety‐like behavior in mice. In contrast, disruption of Fam172a in PVN Oxt neurons exacerbate obesity‐anxiety‐like behavior. Furthermore, this study demonstrates that Fam172a is involved in mRNA degradation in Oxt neurons by regulating the intranuclear transport of Argonaute 2, thereby influencing Oxt secretion and ultimately impacting obesity‐anxiety‐like behavior. These findings suggest that Fam172a serves as a key target of PVN Oxt neurons in the regulation of obesity‐induced anxiety.
Designing Ultra‐Narrow‐Band Red Phosphor via Oxygen Vacancy Engineering for Transparent Display Application
Authors: Wang Wei , Wei Yi , Yang Hang , Sun Jinxuan , Su Fuyan , Liao Hanrui , Zou Hua , Li Mingrui , Li Guogang 
Published: February 2025

AbstractNarrow‐band red phosphors have been crucial in enabling energy‐efficient and wide color gamut display technologies. Developing novel red phosphors with narrower FWHM and suitable positions is still an urgent demand. Herein, a nanorod‐shaped Nb2O5:Pr3+ phosphor, featuring a single ultra‐narrow‐band red emission at 612 nm with FWHM of only 19 nm, is reported. The single narrow‐band is associated with oxygen vacancies, which can influence the electron–hole recombination energy. Besides, the intensity of PL spectra presents anti‐thermal properties and achieves an unexpected 12.5‐fold enhancement from 80 to 280 K. Detailed structural analyses, optical measurements, and DFT calculation are used to investigate abnormal photophysical processes. It canbe found that VO1 has the lowest Eform of 0.70 eV and the electron localization area around the Pr atom enlarges and presents the biggest distortion as VO1 appears. The energy transfer from oxygen vacancies to the luminescent center accounts for the large enhancement. At last, the fabricated transparent display screen presents a transparency of 50% and high color purity (98%), and the LED device shows a large color gamut. These findings advance the understanding of the relationship between luminescent properties and oxygen vacancies, inspiring more design of narrow‐band red phoshors for display applications.
Ultra‐fast and selective recycling of gold from electronic waste based on triiodide ionic liquids
Authors: Yin Xiaolu , Liu Ronghao , Yue Ying , Li Jun , Yang Yanzhao 
Published: February 2025

AbstractThis study introduces a pioneering application of triiodide ionic liquids (ILs) for the efficient and sustainable recovery of gold (Au) from real‐world, various types of electronic wastes. Our method significantly reduces both environmental impact and reagent expenses, while operating under mild conditions. This technique is ideal for practical applications given its ultra‐fast leaching (5 min) and room temperature (35°C) reaction conditions, leading to an unprecedented 11‐fold enhancement in the reaction kinetics relative to aqua regia. Notably, more than 99.3% of Au from e‐waste can be selectively dissolved while excluding non‐target elements like Cu. Compared with conventional dissolution‐extraction processes, our method facilitates the process into a single step. Additionally, the triiodide ILs can be reused for up to six cycles, and have an impressive economic output–input ratio of 1969%, which demonstrates promising technoeconomic feasibility. This approach provides a valuable strategy for profit‐efficient management of e‐waste, promoting a circular economy.
Fabrication of Magnetic Core‐Shell Fe3O4@MnO2@polydopamine Composite for High‐Performance Adsorption of Methylene Blue and Malachite Green in Aqueous Solution
Authors: Zhu Peining , Ma Yong , Gao Yufei 
Published: February 2025

ABSTRACTThe composite material featuring a magnetic core‐shell structure, designated as Fe3O4@MnO2@polydopamine (PDA), has been synthesized for the purpose of eliminating methylene blue (MB) and malachite green (MG) dyes from aqueous solutions. This composite is characterized by the hydrothermal assembly of densely packed manganese dioxide (MnO2) nanosheets onto Fe3O4 microspheres, resulting in a significant enhancement of the composite's specific surface area. The encapsulated PDA exhibits a significant presence of nitrogen and oxygen elements, which serve as active sites for dye adsorption. At a temperature of 298.15 K, the adsorption capacities for MB and MG are measured at 50.17 and 48.73 mg g−1, respectively. Furthermore, at 308.15 K, the adsorption efficiencies for MB and MG are recorded at 98.55% and 97.84%, respectively. The test results indicate that the adsorption behavior is characterized as chemisorption. Furthermore, it adheres to the pseudo‐second‐order kinetic model and the Langmuir isotherm model across various temperatures. The overall process is identified as a spontaneous endothermic reaction, with the rate primarily influenced by micropore diffusion and the equilibrium adsorption associated with intraparticle diffusion. Following the desorption treatment, Fe3O4@MnO2@PDA continues to exhibit effective adsorption capabilities for MB and MG dyes, indicating significant practical application potential.
Mechanically Strong and Thermally Insulating Polyimide Aerogels by Homogeneity Reinforcement of Aluminum Oxide Cluster
Authors: Fu Shihao , Sun Chang , Han Lixin , Li Zhiqiang , Guo Shuai , Li Guangbin , Long Zhu 
Published: February 2025

ABSTRACTHigh‐performance thermal insulation is critically needed in applications where heat transfer must be substantially minimized. Traditional insulating materials, whether organic or inorganic, often suffer from thermal instability or mechanical fragility. Herein, we introduce a series of lightweight, highly porous polyimide/aluminum oxide cluster (PI/AlOC) composite aerogels that exhibit superior thermal insulation properties, achieved through freeze‐drying and thermal imidization processes. The aluminum oxide clusters serve as cross‐linking agents, enhancing the interaction between polyimide molecular chains and endowing the composite with improved structural integrity and mechanical robustness, as evidenced by a compression modulus of 8.7 MPa, six‐fold greater than that of pure PI aerogels. Moreover, the high porosity, reduced pore size, and three‐dimensional network structure of the PI/AlOC composite aerogel confer exceptional thermal insulation performance, particularly at elevated temperatures, surpassing that of commercial thermal insulation materials. Thus, the PI/AlOC composite aerogels, with their high mechanical strength and outstanding thermal insulation, are promising for practical applications in thermal insulation.
Potential Anti‐Filarial Molecules Against ATP Binding Site of MurE Enzyme: A Molecular Docking and Dynamics Approach to Combat Lymphatic Filariasis
Authors: Prabhu Dhamodharan , Dharshini Muthu Krishnan Dhivya , Rajamanikandan Sundararaj , Padmavathi Alwar Ramanujam , Velusamy Palaniyandi , Gopinath Subash C. B. 
Published: February 2025

ABSTRACTLymphatic filariasis (LF) is a mosquito‐borne disease caused by parasitic nematodes Brugia malayi, Brugia timori, and Wuchereria bancrofti. The drugs available are effective in several cases, and the absence of vaccination is the crucial factor hindering the elimination of LF. The UDP‐N‐acetylmuramoyl‐L‐alanyl‐D‐glutamate‐2,6‐diaminopimelate ligase (MurE) plays an important role in the peptidoglycan biosynthesis of Wolbachia endosymbiont B. malayi, which are reported to be a vital drug target for bacterial and endosymbiotic hosts. Thus, we selected the ATP binding cavity of MurE as the potential site to screen inhibitors. The MurE structure was modeled using AlphaFold due to the absence of an experimental structure. Structure‐based screening identified five potent phytochemicals targeting the ATP binding site with higher Glide scores and affinity. The top five phytochemicals CID 311, CID 445713, CID 441626, CID 39077, and CID 10814 showed a docking score of −16.812, −16.117, −15.668, −15.324, and −13.442 kcal/mol, respectively. Further, the molecular dynamics simulations depicted the binding stability of the phytochemical inhibitors bound to the MurE complex. Moreover, ADME assessment and Density Functional Theory analyses of the predicted compounds have shown acceptable pharmacokinetic properties and high reactivity with the drug target of MurE.
A 3D Bioprinted Gelatine‐Based Bilayer Hydrogel Dressing Loaded With Curcumin and Ciprofloxacin Hydrochloride With Antibacterial, Anti‐Inflammatory and Antioxidative Properties
Authors: Feng Zijiao , Liu Jiaqi , Lu Yueqi , Ma Hailin , Cheng Yuen Yee , Xu Jie , Guan Yanchun , Pan Bo , Song Kedong 
Published: February 2025

ABSTRACTSkin wound repair, a highly integrated and overlapping complex process, is susceptible to infection, excessive inflammation, high oxidative stress, which can prolong the wound healing time or even lead to chronic wound. Meanwhile, single‐layer hydrogels are unavoidably dehydrated usually due to water evaporation, which is not conducive to wound healing. Therefore, a bilayer hydrogel dressing composed of gelatin (G) and sodium alginate (A) loaded with ciprofloxacin (C) and curcumin (Cur) was manufactured by extrusion 3D bioprinting technology in this study, which is denoted as GACCur. The experimental results showed that the bilayer hydrogel loaded with 50 µg/mL of Cur (GACCur50) had excellent antibacterial properties and high antioxidative activity with a 54.35 ± 0.48% DPPH scavenging ratio. In addition, this GACCur50 bilayer hydrogel exhibited the capacity to mitigate the polarization of inflammatory cells toward pro‐inflammatory states, observably reducing the expression of pertinent pro‐inflammatory cytokines. Furthermore, the bilayer hydrogel dressing also showed good biocompatibility as assessed by live‐dead fluorescent staining, scanning electron microscopy (SEM), and CCK‐8 test. Therefore, the GACCur50 bilayer hydrogel dressing is promising for wound healing.
Kalanchoe crenata Haw. (Crassulacea) Decreases Hippocampal Neuron Loss and Improves Memory and Executive Function in Aged Rats: Implications for Anti‐Inflammatory and Antioxidant Mechanisms
Authors: Kandeda Antoine Kavaye , Mezui Christophe , Kengni Sandry , Baldagai Ndeva , Mabou Symphorien Talom 
Published: February 2025

ABSTRACTIntroductionAlzheimer's disease is a neurodegenerative disease that alters learning and memory processes. Kalanchoe crenata (Crassulaceae) has long been used in Cameroonian traditional medicine to treat hypertension, malaria, and dementia. The present study aims to evaluate the anti‐amnesic effect of an aqueous extract of K. crenata in D‐galactose‐treated rats and possible mechanisms of action.MethodsMemory impairment was induced in rats by subcutaneous injection of D‐galactose (350 mg/kg) once daily for 30 days. At the end of the procedure, the animals were assessed for memory impairment using Morris water maze and object recognition tasks. Animals with memory impairment were divided into six groups of eight rats each and treated once daily for 24 days as follows: the negative control group received per os distilled water (10 mL/kg); the positive control group received donepezil (2 mg/kg, p.o.); and three test groups received the extract of K. crenata (62, 124, and 248 mg/kg, p.o.). A group of eight rats was added and served as a control group. After completion of the procedure, the memory deficit in rats was reassessed by the object recognition test on Day 15 of the treatment, the Morris water maze test on Day 18, and the open‐field test on Day 24. At the end of behavioral experiments, the animals were sacrificed and some biochemical parameters in the hippocampus were estimated. In addition, histological analysis of the hippocampus was performed.ResultsK. crenata significantly decreased the time to reach the platform and increased the time spent in the target quadrant of the Morris water maze. It also increased the discrimination index during the object recognition test. The extract significantly reversed D‐galactose‐induced oxidative stress and inflammation. This was confirmed by the attenuation of neuronal loss.ConclusionThese findings suggest that K. crenata extract possesses an anti‐amnesic‐like effect probably mediated by antioxidant and anti‐inflammatory mechanisms.
Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion‐Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway
Authors: Wu Qiaolan , Zhou Yang , Ou Chunxue , Gao Zu , Wu Xiaolin , Zhao Yue , Wang Yuan , Wu Zhichun , Yu Huayun 
Published: February 2025

ABSTRACTAimsTo evaluate the effects of Jiawei Kongsheng Zhenzhong Pill (JKZP) on rats with ischemic mild cognitive impairment (MCI) and investigate the underlying mechanisms.MethodsThe components of JKZP were analyzed using Q‐Orbitrap high‐resolution mass spectrometry (HRMS). The MCI rat model was prepared through gradual bilateral common carotid artery occlusion (BCCAO). The cognitive function, hippocampal pathological lesions, dendritic spine damage, synapse‐related, and S100 calcium‐binding protein A10 (S100A10)/tissue‐type plasminogen activator (tPA)/brain‐derived neurotrophic factor (BDNF) pathway‐associated molecules alterations were measured. Primary hippocampus neurons were subjected to oxygen‐glucose deprivation/reperfusion (OGD/R) injury, and JKZP‐containing serum was utilized for treatment. Lentiviral‐infected neurons were constructed with S100A10 knockdown using RNAi technology to investigate whether JKZP exerted its anti‐MCI effects via S100A10/tPA/BDNF pathway.ResultsA total of 64 major components, including β‐asarone, ferulic acid, loganin, senkyunolide H, and cryptotanshinone, were identified by Q‐Orbitrap HRMS technology. JKZP had a notable impact on enhancing the cognitive abilities of rats with MCI. JKZP reduced the damage to the hippocampal CA1 region neuron and synaptic structure, reversed the decrease in dendritic spines, and increased the expressions of synapse‐associated proteins such as synaptophysin (SYN), growth‐associated protein 43 (GAP43), and postsynaptic density protein 95 (PSD95). Furthermore, JKZP treatment dramatically reduced the ratio of protein of BDNF (proBDNF)/mature BDNF (mBDNF) by activating S100A10/tPA, which was confirmed in primary hippocampus neurons in vitro. Moreover, sh‐S100A10 tremendously mitigated the inhibitory action of JKZP on OGD/R‐mediated synapse injury, decreased the activity of tPA, and thus improved the downstream pathway targets’ ratio, proBDNF/mBDNF.ConclusionsThese results manifested that JKZP promoted neurological recovery after chronic cerebral ischemia by alleviating synaptic damage and activating the S100A10/tPA/BDNF pathway, thereby providing a novel perspective and a solid foundation against MCI.
Multi‐Objective Dynamic Registry Provisioning in Edge Computing Infrastructures
Authors: Roges Lucas , Ferreto Tiago 
Published: February 2025

ABSTRACTThe rise of mobile devices and IoT sensors has led to the development of latency‐sensitive, data‐oriented, and resource‐intensive applications. These devices often lack sufficient processing and storage capabilities, but cloud computing can provide the necessary support. However, the distance to cloud data centers causes communication delays. Edge computing addresses this by bringing computational resources closer to users, and improving latency and bandwidth. Container‐based virtualization further enhances QoS and QoE due to its lightweight nature, enabling faster application provisioning and reduced resource overhead. Despite these benefits, container provisioning faces significant overhead during content downloads from registries. Existing solutions often focus only on reducing provisioning time, neglecting critical metrics like latency and resource usage. Some approaches use complex techniques like registry migration, which can harm network utilization. We introduce MODyn, a multi‐objective dynamic provisioning strategy for container registries. MODyn allocates container registries to edge servers based on infrastructure analysis, eliminating the need for resource migration. Our evaluation shows that MODyn balances provisioning time, latency, and resource usage, optimizing container‐based application deployment in edge computing.
Design of Direct Synthesis–Based Cascaded PI Controller for PMSM Drive With Improved Nonlinear Disturbance Observer
Authors: Savarn Anurag , Verma Vimlesh , Nishat Anwar Md. 
Published: February 2025

ABSTRACTThis paper focuses on the design of a disturbance observer–based control technique to improve the robustness and speed tracking performance of permanent magnet synchronous motor (PMSM) drive under external load disturbances and machine parameter variation. PI controller in a cascaded fashion is used in both the loops for current and speed control. The parameters of the controller are designed using a linearized model of PMSM by direct‐synthesis approach. Generally, the drive's performance is degraded in the presence of disturbances, so an enhanced nonlinear disturbance observer is proposed by using a nonlinear design function to improve the antidisturbance performance. The proposed disturbance observer effectively estimates lumped disturbances and feeds them forward for compensation. The suggested control technique is tested in MATLAB/SIMULINK environment and its efficacy has been validated by experimental demonstration on a laboratory‐based setup of PMSM drive with d‐SPACE 1104. The comparative results with PI and internal model controller (IMC) under various scenarios of load torque disturbances are analyzed to prove the superiority of the proposed control technique.
Optimized Efficient Predefined Time Adaptive Neural Network for Identifying Parameters in Quantum Bit Error Rate
Authors: Ilakkiaselvan D. , Kavitha R. J. 
Published: February 2025

ABSTRACTAn Optimized Efficient Predefined Time Adaptive Neural Network for Identifying Parameters in Quantum Bit Error Rate (EPTANN‐IP‐QBER) is proposed in this manuscript. Here, the input signals are gathered from 6G wireless networks that face obstacles channel. To execute this, the High‐Level Target Navigation Pigeon‐Inspired Optimization (HLTNPIO) is used to extend the maximum transmission distances and improve the secret key rates of input signals. Then, improved secret key rates input signals are fed to EPTANN for effectively identifying the parameters such as laser linewidth, channel dispersion, decoy states, error correction rate, privacy amplification efficiency, eavesdropping detection, scalability, and photon encoding optimization in quantum bit error rates (QBERs). Generally, EPTANN does not adapt any optimization approaches to determine optimal parameters to identify the parameters in QBER. Hence, the Snow Avalanches Algorithm (SAA) is employed to optimize the EPTANN, which accurately identifies the parameter in QBER reduction. The proposed EPTANN‐IP‐QBER is implemented in Python. The performance metrics, like accuracy, precision, secure key rate, QBER, transmission distance, and computational time, are analyzed. The performance of the EPTANN‐IP‐QBER approach attains 20.25%, 18.36%, and 23.28% lower QBER; 29.56%, 19.42%, and 27.74% higher accuracy; and 16.21%, 20.26%, and 26.96% higher precision when analyzed to the existing methods: Millimeter‐Waves to Terahertz SISO along MIMO Continuous‐Variable Quantum Key Distribution (TSISO‐MIMO‐VQKD), MIMO Terahertz QKD utilizing Restricted Eavesdropping (MIMO‐QKD‐URE), and single‐emitter quantum key distribution more than 175 km of fiber by optimized finite key rates (SEQKD‐FKR) methods, respectively.
Low Genetic Diversity and Complex Population Structure in Black Piranha (Serrasalmus rhombeus), a Key Amazonian Predator
Authors: Thomas Alizée , Sylvain François‐Étienne , Normandeau Eric , Leroux Nicolas , Holland Aleicia , Val Adalberto Luis , Derome Nicolas 
Published: February 2025

ABSTRACTThe black piranha (Serrasalmus rhombeus), a widely spread species in the rivers of the Amazon basin, plays a vital role as both key predator and important prey. Despite its essential contribution to ecosystem stability, there is a lack of information regarding its genetic diversity and population dynamics in the central Amazon region. As the Amazon continues to undergo environmental changes in the context of growing anthropogenic threats, such knowledge is fundamental for assist in the conservation of this species. This study is the first to analyze the genetic diversity and population structure of S. rhombeus in the central Amazon region using high‐resolution genomic data. We employed a Genotyping‐by‐Sequencing approach with 248 samples across 14 study sites from various tributaries, encompassing diverse water types (black, white, and clear water) and characterized by 34 physiochemical parameters. The data reveals low diversity accompanied by pronounced signs of inbreeding in half of the sites and robust genetic differentiation and variation among sites and within‐sites. Surprisingly, we also found evidence of higher dispersal capacity than previously recognized. Our analysis exposed a complex and high population structure with genetic groups exclusive to some sites. Gene flow was low and some groups presented ambiguous genealogical divergence index (gdi) signals, suggesting the occurrence of potential cryptic species. Moreover, our results suggest that the population structure of black piranha appears more influenced by historical events than contemporary factors. These results underscore the need to give greater attention to this keystone species, for which no regulatory framework or conservation strategies is presently in effect.