bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normal Rights, Just New: Understanding the Judicial Enforcement of Socioeconomic Rights
Authors: Fowkes James 
Published: December 2020

Abstract
A common skeptical view holds that socioeconomic rights are a different kind of right than civil-political rights. Even those who support justiciable socioeconomic rights often see them as a different kind of right with special challenges. I argue that this view is wrong. What all these observers are reacting to is not an inherent property of socioeconomic rights: it is a contingent property of a situation in which judges are asked to enforce a rights claim without a pre-existing set of familiar public understandings of the right’s content and/or an existing structure of officials and procedures to give effect to that content. It is because the rights claim is new, and this is something that can be, and often is, true of rights across the spectrum. Any rights claim is problematic to enforce to the degree that it is new, but these obstacles can and do disappear if society changes and the claim becomes less new. In the first part of the Article, I seek to establish the accuracy of this argument, drawing on examples of rights distinctions from the nineteenth-century United States and rights across the spectrum displaying newness in contemporary South Africa and India. I then show how controlling for newness can help us to understand standard features of the socioeconomic rights debate: the ubiquitous, but misleading, negative–positive distinction; arguments about resources; Fuller’s endlessly cited polycentricity argument; and current controversial cases, such as the budget-shifting judicial enforcement of Latin American healthcare entitlements. These topics are central to our widespread intuition that socioeconomic rights are different; newness can help us to see that this intuition is misleading us, and by recalibrating the debate can filter out some distractions that have long dogged it.
Analysis of microRNA Expression in Liquid-Based Cytology Samples May Be Useful for Primary Lung Cancer Diagnosis
Authors: Araki Yusuke , Arihiro Koji , Yamaguchi Kakuhiro , Sakamoto Shinjiro , Horimasu Yasushi , Masuda Takeshi , Miyamoto Shintaro , Nakashima Taku , Iwamoto Hiroshi , Fujitaka Kazunori , Hamada Hironobu , Hattori Noboru 
Published: December 2020

Abstract

Objectives
Bronchoscopy is frequently performed for patients suspected of having lung cancer; however, we sometimes fail to make a definitive diagnosis, resulting in additional invasive testing. Many studies indicate that microRNAs (miRs) are abnormally expressed in cancers. We examined the diagnostic value of 4 miRs (miR-21, miR-31, miR-182, and miR-183) extracted from liquid-based cytology (LBC) samples and validated whether they were diagnostically useful.

Methods
We collected 18 surgically resected tissue samples and 136 LBC specimens obtained during bronchoscopic examination at Hiroshima University Hospital. We extracted RNA from these samples and compared the expression of 4 miRs by reverse transcription–quantitative polymerase chain reaction.

Results
We confirmed that expression of the 4 miRs was significantly higher in cancer tissues than in tumor-adjacent normal tissues. We examined the expression of these miRs in 125 (cancer cases, 83; noncancer cases, 42) of 136 cytologic samples. Expression of all 4 miRs was significantly higher in patients with lung cancer than in those without lung cancer. Among samples judged as benign or indeterminate, levels of these miRs were also significantly higher in patients with lung cancer than in those without lung cancer.

Conclusions
The analysis of miR expression in LBC samples might be helpful for primary lung cancer diagnosis.
Gun acquisition in Mexico 2012–18: findings from Mexico𔃻s National Crime Victimization Survey
Authors: Weigend Vargas Eugenio , Pérez Ricart Carlos 
Published: December 2020

Abstract
Data from Mexico’s National Crime Victimization Surveys (Encuesta Nacional de Victimización y Percepción sobre Seguridad Pública, ENVIPE) indicate that 1.89 million Mexican households acquired a gun from 2012 to 2018. The objective of this article is to analyse factors associated with gun acquisition in Mexico. We analysed data from the 2013 through 2019 ENVIPE surveys and ran a binary logistic regression. Our results show that gun acquisition in Mexico is associated with the demographics of the head of the household, characteristics of the household, perception of insecurity, illegal activities around a household, victimization and mistrust in security agencies. This study adds to efforts of understanding gun acquisition worldwide while also contributing to the complex research of guns and violence in Latin America, specifically in Mexico.
Genomic analysis of patients in a South Indian Community with autosomal dominant cortical tremor, myoclonus and epilepsy suggests a founder repeat expansion mutation in theSAMD12gene
Authors: Mahadevan Radha , Bhoyar Rahul C , Viswanathan Natarajan , Rajagopal Raskin Erusan , Essaki Bobby , Suroliya Varun , Chelladurai Rachel , Sankaralingam Saravanan , Shanmugam Ganesan , Vayanakkan Sriramakrishnan , Shamim Uzma , Mathur Aradhana , Jain Abhinav , Imran Mohamed , Faruq Mohammed , Scaria Vinod , Sivasubbu Sridhar , Kalyanaraman Shantaraman 
Published: December 2020

AbstractAutosomal Dominant Cortical Tremor, Myoclonus and Epilepsy is a non-progressive disorder characterized by distal tremors. Autosomal Dominant Cortical Tremor, Myoclonus and Epilepsy has been reported globally with different genetic predispositions of autosomal dominant inheritance with a high degree of penetrance. In south India, Autosomal Dominant Cortical Tremor, Myoclonus and Epilepsy has been reported in a large cohort of 48 families, in which the genetic defect was not identified. This report pertains to the whole-genome analysis of four individuals followed by repeat-primed PCR for 102 patients from a familial cohort of 325 individuals. All the patients underwent extensive clinical evaluation including neuropsychological examinations. The whole-genome sequencing was done for two affected and two unaffected individuals, belonging to two different families. The whole-genome sequencing analysis revealed the repeat expansion of TTTTA and TTTCA in intron 4 of the SAMD12 gene located on chromosome 8 in the patients affected with Autosomal Dominant Cortical Tremor, Myoclonus and Epilepsy, whereas the unaffected family members were negative for the similar expansion. Further, the repeat-primed PCR analysis of 102 patients showed the expansion of the TTTCA repeats in the intron 4 of SAMD12 gene. All patients registered for this study belong to a single community called “Nadar” whose nativity is confined to the southern districts of India, with reported unique genetic characteristics. This is the largest and most comprehensive single report on clinically and genetically characterized Autosomal Dominant Cortical Tremor, Myoclonus and Epilepsy patients belonging to a unique ethnic group worldwide.
Real-time imputation of missing predictor values in clinical practice
Authors: Nijman Steven W J , Hoogland Jeroen , Groenhof T Katrien J , Brandjes Menno , Jacobs John J L , Bots Michiel L , Asselbergs Folkert W , Moons Karel G M , Debray Thomas P A 
Published: December 2020

AbstractAimsUse of prediction models is widely recommended by clinical guidelines, but usually requires complete information on all predictors, which is not always available in daily practice. We aim to describe two methods for real-time handling of missing predictor values when using prediction models in practice.Methods and resultsWe compare the widely used method of mean imputation (M-imp) to a method that personalizes the imputations by taking advantage of the observed patient characteristics. These characteristics may include both prediction model variables and other characteristics (auxiliary variables). The method was implemented using imputation from a joint multivariate normal model of the patient characteristics (joint modelling imputation; JMI). Data from two different cardiovascular cohorts with cardiovascular predictors and outcome were used to evaluate the real-time imputation methods. We quantified the prediction model’s overall performance [mean squared error (MSE) of linear predictor], discrimination (c-index), calibration (intercept and slope), and net benefit (decision curve analysis). When compared with mean imputation, JMI substantially improved the MSE (0.10 vs. 0.13), c-index (0.70 vs. 0.68), and calibration (calibration-in-the-large: 0.04 vs. 0.06; calibration slope: 1.01 vs. 0.92), especially when incorporating auxiliary variables. When the imputation method was based on an external cohort, calibration deteriorated, but discrimination remained similar.ConclusionsWe recommend JMI with auxiliary variables for real-time imputation of missing values, and to update imputation models when implementing them in new settings or (sub)populations.
Low lipoprotein(a) levels and risk of disease in a large, contemporary, general population study
Authors: Langsted Anne , Nordestgaard Børge G , Kamstrup Pia R 
Published: December 2020

Abstract

Aims
With the current focus on lipoprotein(a) as a likely causal risk factor for cardiovascular disease and new drugs potentially on the market to lower lipoprotein(a) levels, the safety of lowering lipoprotein(a) to low levels becomes increasingly important. We tested whether low levels of lipoprotein(a) and corresponding LPA genotypes associate with major disease groups including cancers and infectious disease.

Methods and results
We included 109 440 individuals from the Copenhagen General Population Study. For main World Health Organization International Classification of Diseases 10th edition chapter diseases, the only concordant association of low levels of lipoprotein(a) plasma levels and corresponding LPA genotypes with risk of disease was with low risk of diseases of the circulatory system. Furthermore, no concordant association of low levels of lipoprotein(a) plasma levels and corresponding LPA genotypes with the risk of any cancer (i.e. cancer subtypes combined) or infectious disease was seen. The hazard ratio for the risk of any cancer was 1.06 [95% confidence interval (CI): 0.97–1.15] for the first vs. the fourth quartile of lipoprotein(a), 1.02 (0.97–1.07) for the fourth vs. the first quartile of KIV-2 number of repeats, and 1.01 (0.96–1.07) for rs10455872 non-carriers vs. carriers. The corresponding hazard ratios for the risk of hospitalization for infection were 1.05 (95% CI: 0.99–1.10), 1.02 (0.98–1.07), and 0.97 (0.93–1.03), respectively.

Conclusion
In a large, contemporary, general population cohort, apart from the well-established association with cardiovascular disease, low levels of lipoprotein(a) and corresponding LPA genotypes did not concordantly associate with any major disease groups including cancers and infections. There is no safety signal from our results to indicate that low levels of lipoprotein(a) are harmful.
66 Relative efficacy of sacubitril/valsartan, dapagliflozin and vericiguat: a systematic review and network meta-analysis
Authors: Georgiopoulos Georgios , Aimo Alberto , Pateras Kostantinos , Stamatelopoulos Kimon , Lombardi Carlo Mario , Passino Claudio , Emdin Michele 
Published: December 2020

Abstract

Aims
Sacubitril/valsartan, dapagliflozin and vericiguat have shown a prognostic benefit in phase 3 trials on heart failure with reduced ejection fraction (HFrEF). Assessing their relative efficacy is an important goal.

Methods and results
We assessed the relative efficacy of dapagliflozin, sacubitril/valsartan and vericiguat, by comparing the treatment arms with the respective control arms (standard of care) through a network meta-analysis.
The phase 3 trials (PARADIGM-HF, DAPA-HF, VICTORIA), the HFrEF subgroup of DECLARE-TIMI 58, and a phase 2 trial on vericiguat were evaluated. Dapagliflozin was associated with a non-significant reduction in the risk of cardiovascular (CV) death or HF hospitalization compared to sacubitril/valsartan (hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.64 to 1.22) and vericiguat (HR 0.82, 95% CI 0.6 to 1.12). The risk of CV death did not differ significantly between patients on dapagliflozin or sacubitril/valsartan (HR 0.90, 95% CI 0.51 to 1.58), and between patients on dapagliflozin or vericiguat (HR 0.77, 95% CI 0.44 to 1.37). As for HF hospitalization, dapagliflozin conferred a significant benefit over vericiguat (HR 0.77, 95% CI 0.63 to 0.93), but not over sacubitril/valsartan (HR 0.87, 95% CI 0.72 to 1.06). Dapagliflozin was ranked as the most effective therapy, followed by sacubitril/valsartan and vericiguat.

Conclusion
Based on an indirect comparison, dapagliflozin is not associated with a significantly lower risk of CV death or HF hospitalization or CV death alone compared to sacubitril/valsartan or vericiguat. The risk of HF hospitalization does not differ significantly between patients on dapagliflozin or sacubitril/valsartan, while dapagliflozin is superior to vericiguat.

Registration number
PROSPERO ID 186351.
506 Uneventful pseudoaneurysm of the ascending aorta with sternal erosion in pregnancy
Authors: Benedetti Alice , Del Monte Alvise , Rubino Maurizio , Mancuso Daniela 
Published: December 2020

Abstract
A 36-year-old woman at 31 weeks’ gestation presented with exertional dyspnoea and palpitations. She had a history of bicuspid aortic valve treated with surgical aortic valvotomy for severe stenosis, followed by ascending aorta replacement for type A acute aortic dissection and Bentall operation with a mechanical valve for severe aortic regurgitation. Eight years after the last surgery, magnetic resonance angiography showed aortic arch aneurysm (49 mm) with a small intimal flap. Thereafter, the patient was lost to follow-up until the current admission. She was hemodynamically stable on presentation and physical examination was unremarkable apart from a mechanical second heart sound. The electrocardiogram showed sinus rhythm with left bundle branch block (Panel A). Transthoracic echocardiography revealed severe left ventricular dilation (EDV 90 ml/m2) with mild dysfunction (EF 50%), normal prosthetic aortic valve function, and aortic arch dilation (50 mm) (Panel B and C). After a multidisciplinary evaluation, elective cesarean section was performed at 34 weeks’ gestation. A post-delivery aortic computed tomography angiography revealed aortic arch aneurysm (52 mm) with intimal flap and two pseudoaneurysms of the anterior aortic wall causing sternal erosion (Panel D, E, F and G). Subsequently, the patient underwent ascending aorta and aortic arch replacement by Frozen Elephant Trunk technique with a 24 x130 mm prosthesis between the aortic root and the descending aorta. The postoperative course was uneventful, and the patient was discharged to a cardiac rehabilitation centre.
Risk of ventricular arrhythmia in cardiac resynchronization therapy responders and super-responders: a systematic review and meta-analysis
Authors: Yuyun Matthew F , Erqou Sebhat A , Peralta Adelqui O , Hoffmeister Peter S , Yarmohammadi Hirad , Echouffo Tcheugui Justin B , Martin David T , Joseph Jacob , Singh Jagmeet P 
Published: December 2020

Abstract

Aims
Response to cardiac resynchronization therapy (CRT) is associated with improved survival, and reduction in heart failure hospitalization, and ventricular arrhythmia (VA) risk. However, the impact of CRT super-response [CRT-SR, increase in left ventricular ejection fraction (LVEF) to ≥ 50%] on VA remains unclear.

Methods and results
We undertook a meta-analysis aimed at determining the impact of CRT response and CRT-SR on risk of VA and all-cause mortality. Systematic search of PubMed, EMBASE, and Cochrane databases, identifying all relevant English articles published until 31 December 2019. A total of 34 studies (7605 patients for VA and 5874 patients for all-cause mortality) were retained for the meta-analysis. The pooled cumulative incidence of appropriate implantable cardioverter-defibrillator therapy for VA was significantly lower at 13.0% (4.5% per annum) in CRT-responders, vs. 29.0% (annualized rate of 10.0%) in CRT non-responders, relative risk (RR) 0.47 [95% confidence interval (CI) 0.39–0.56, P &lt; 0.0001]; all-cause mortality 3.5% vs. 9.1% per annum, RR of 0.38 (95% CI 0.30–0.49, P &lt; 0.0001). The pooled incidence of VA was significantly lower in CRT-SR compared with CRT non-super-responders (non-responders + responders) at 0.9% vs. 3.8% per annum, respectively, RR 0.22 (95% CI 0.12–0.40, P &lt; 0.0001); as well as all-cause mortality at 2.0% vs. 4.3%, respectively, RR 0.47 (95% CI 0.33–0.66, P &lt; 0.0001).

Conclusions
Cardiac resynchronization therapy super-responders have low absolute risk of VA and all-cause mortality. However, there remains a non-trivial residual absolute risk of these adverse outcomes in CRT responders. These findings suggest that among CRT responders, there may be a continued clinical benefit of defibrillators.
De Novo variants in EEF2 cause a neurodevelopmental disorder with benign external hydrocephalus
Authors: Nabais Sá Maria J , Olson Alexandra N , Yoon Grace , Nimmo Graeme A M , Gomez Christopher M , Willemsen Michèl A , Millan Francisca , Schneider Alexandra , Pfundt Rolph , de Brouwer Arjan P M , Dinman Jonathan D , de Vries Bert B A 
Published: December 2020

Abstract
Eukaryotic translation elongation factor 2 (eEF2) is a key regulatory factor in gene expression that catalyzes the elongation stage of translation. A functionally impaired eEF2, due to a heterozygous missense variant in the EEF2 gene, was previously reported in one family with spinocerebellar ataxia-26 (SCA26), an autosomal dominant adult-onset pure cerebellar ataxia. Clinical exome sequencing identified de novo EEF2 variants in three unrelated children presenting with a neurodevelopmental disorder (NDD). Individuals shared a mild phenotype comprising motor delay and relative macrocephaly associated with ventriculomegaly. Populational data and bioinformatic analysis underscored the pathogenicity of all de novo missense variants. The eEF2 yeast model strains demonstrated that patient-derived variants affect cellular growth, sensitivity to translation inhibitors and translational fidelity. Consequently, we propose that pathogenic variants in the EEF2 gene, so far exclusively associated with late-onset SCA26, can cause a broader spectrum of neurologic disorders, including childhood-onset NDDs and benign external hydrocephalus.
Disruption and recovery of testicular function during and after androgen abuse: the HAARLEM study
Authors: Smit D L , Buijs M M , de Hon O , den Heijer M , de Ronde W 
Published: December 2020

Abstract

STUDY QUESTION
What is the speed and extent by which endogenous testosterone production and spermatogenesis recover after androgen abuse?

SUMMARY ANSWER
Testosterone concentrations normalized within 3 months after discontinuation of androgen abuse in most subjects but recovery of spermatogenesis took longer—approximately 1 year.

WHAT IS KNOWN ALREADY
An estimated 4–6% of amateur strength athletes use androgens. Abuse of supraphysiological doses of androgens completely suppresses endogenous testosterone production and spermatogenesis.

STUDY DESIGN, SIZE, DURATION
Prospective and observational cohort study in which 100 male amateur athletes participated for 1 year.

PARTICIPANTS/MATERIALS, SETTING, METHODS
Subjects (≥18 years) were included if they had not used androgens for at least 3 months and intended to start an androgen cycle within 2 weeks. Clinic visits took place before (T0), at the end (T1), and 3 months after the end of the cycle (T2), and 1 year after start of the cycle (T3), and included a blood test for gonadotrophins and sex hormones, and semen analysis.

MAIN RESULTS AND THE ROLE OF CHANCE
During androgen abuse, 77% of subjects had a total sperm count (TSC) below 40 million. Three months after the end of the cycle (T2), total (−1.9 nmol/l, CI −12.2 to 8.33, P = 0.71) and free (−38.6 pmol/l, CI −476 to 399, P = 0.86) testosterone concentrations were not different compared to baseline, whereas mean TSC was 61.7 million (CI 33.7 to 90.0; P &lt; 0.01) lower than baseline. At the end of follow-up (T3), there was no statistically significant difference for total (−0.82 nmol/l, CI −11.5 to 9.86, P = 0.88) and free (−25.8 pmol/l, CI −480 to 428, P = 0.91) testosterone compared to baseline, but there was for TSC (−29.7 million, CI −59.1 to −0.39, P = 0.05). In nine (11%) subjects, however, testosterone concentrations were below normal at the end of follow-up (T3), and 25 (34%) subjects still had a TSC below 40 million.

LIMITATIONS, REASONS FOR CAUTION
The follow-up period (after the cycle) was relatively short, especially considering the long recovery time of spermatogenesis after discontinuation of androgens.

WIDER IMPLICATIONS OF THE FINDINGS
Endogenous testosterone production and spermatogenesis recover following androgen abuse in the vast majority of users. Nevertheless, not all users achieve a normalized testicular function. This may especially be the case for athletes with a high past exposure to androgens.

STUDY FUNDING/COMPETING INTEREST(S)
There is no conflict of interest. The study was funded by the Spaarne Gasthuis academy.

TRIAL REGISTRATION NUMBER
N/A.
Antagonism of Adherent Invasive E. coli LF82 With Human α-defensin 5 in the Follicle-associated Epithelium of Patients With Ileal Crohn’s Disease
Authors: Alkaissi Lina Y , Winberg Martin E , Heil Stéphanie D S , Haapaniemi Staffan , Myrelid Pär , Stange Eduard F , Söderholm Johan D , Keita Åsa V 
Published: December 2020

Abstract

Background
The first visible signs of Crohn’s disease (CD) are microscopic erosions over the follicle-associated epithelium (FAE). The aim of the study was to investigate the effects of human α-defensin 5 (HD5) on adherent-invasive Escherichia coli LF82 translocation and HD5 secretion after LF82 exposure in an in vitro model of human FAE and in human FAE ex vivo.

Methods
An in vitro FAE-model was set up by the coculture of Raji B cells and Caco-2-cl1 cells. Ileal FAE from patients with CD and controls were mounted in Ussing chambers. The effect of HD5 on LF82 translocation was studied by LF82 exposure to the cells or tissues with or without incubation with HD5. The HD5 secretion was measured in human FAE exposed to LF82 or Salmonella typhimurium. The HD5 levels were evaluated by immunofluorescence, immunoblotting, and ELISA.

Results
There was an increased LF82 translocation across the FAE-model compared with Caco-2-cl1 (P &lt; 0.05). Incubation of cell/tissues with HD5 before LF82 exposure reduced bacterial passage in both models. Human FAE showed increased LF82 translocation in CD compared with controls and attenuated passage after incubation with sublethal HD5 in both CD and controls (P &lt; 0.05). LF82 exposure resulted in a lower HD5 secretion in CD FAE compared with controls (P &lt; 0.05), whereas Salmonella exposure caused equal secretion on CD and controls. There were significantly lower HD5 levels in CD tissues compared with controls.

Conclusions
Sublethal HD5 reduces the ability of LF82 to translocate through FAE. The HD5 is secreted less in CD in response to LF82, despite a normal response to Salmonella. This further implicates the integrated role of antimicrobial factors and barrier function in CD pathogenesis.