bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased collection efficiency of CD34+ cells after mobilization with preemptive use of plerixafor followed by leukocytapheresis on the same day
Authors: Cid Joan , Castillo Carlos , Marín Pedro , Carbassé Gloria , Herrera Dolores , Monfort Nuria , Fernández‐Avilés Francesc , Gutiérrez‐García Gonzalo , Martínez Carmen , Rosiñol Laura , Suárez‐Lledó María , Rovira Montserrat , Urbano‐Ispizua Álvaro , Lozano Miquel 
Published: February 2020

BACKGROUNDPlerixafor should be administered 6 to 11 hours before starting leukocytapheresis. However, we have been using plerixafor followed by leukocytapheresis according to different time schedules since 2007. Our objective was to compare the CD34+ cell collection efficiency (CE1) of the first leukocytapheresis performed after using plerixafor at different time intervals.STUDY DESIGN AND METHODSSame‐day schedule refers to the administration of plerixafor at 10:00 AM and starting the leukocytapheresis on the same day at 4:00 PM (6 hours interval). Next‐day schedule refers to the administration of plerixafor at 8:00 PM and starting the leukocytapheresis on the next day (10:00 AM or 4:00 PM; either a 14‐ or 20‐hr interval). Variables that might influence the CE1 of CD34+ cells were analyzed by longitudinal linear regression with a random effects model derived by generalized estimating equations.RESULTSThe median CE1 of CD34+ cells was higher in the group of 30 patients who underwent leukocytapheresis on the same day when compared with the group of 62 patients who underwent leukocytapheresis on the next day (65.8% vs. 56.7%; p < 0.01). In the longitudinal linear regression analysis, only the time from plerixafor administration to leukocytapheresis start was associated with a statistically significant decrease in the CE1 of CD34+ cells (CE1 change −0.034%; p < 0.01).CONCLUSIONHigher CE1 of CD34+ cells was observed when patients underwent leukocytapheresis on the same day after receiving plerixafor in comparison with administering plerixafor and underwent leukocytapheresis on the next day. Larger studies are necessary to confirm present results.
Cryptosporidium and Giardia in locally harvested clams in Iqaluit, Nunavut
Authors: Manore Anna J. W. , Harper Sherilee L. , Sargeant Jan M. , Weese J. Scott , Cunsolo Ashlee , Bunce Anna , Shirley Jamal , Sudlovenick Enooyaq , Shapiro Karen 
Published: February 2020

AbstractHigh prevalences of Cryptosporidium and Giardia were recently found in enteric illness patients in the Qikiqtaaluk region of Nunavut, Canada, with a foodborne, waterborne or animal source of parasites suspected. Clams (Mya truncata) are a commonly consumed, culturally important and nutritious country food in Iqaluit; however, shellfish may concentrate protozoan pathogens from contaminated waters. The goal of this work was to investigate clams as a potential source of Cryptosporidium and Giardia infections in residents in Iqaluit, Nunavut. The objectives were to estimate the prevalence and genetically characterize Cryptosporidium and Giardia in locally harvested clams. Clams (n = 404) were collected from Iqaluit harvesters in September 2016. Haemolymph (n = 328) and digestive gland (n = 390) samples were screened for Cryptosporidium and Giardia via PCR, and amplified products were further processed for sequence analyses for definitive confirmation. Giardia DNA was found in haemolymph from 2 clams, while Cryptosporidium was not detected. The two Giardia sequences were identified as zoonotic Giardia enterica assemblage B. The overall prevalence of Giardia in clams near Iqaluit was low (0.6%) compared with other studies in southern Canada and elsewhere. The presence of Giardia DNA in clams suggests human or animal faecal contamination of coastal habitat around Iqaluit in shellfish harvesting waters. Results from this study are intended to inform public health practice and planning in Inuit Nunangat.
Evaluation of Dose-Fractionated Polymyxin B on Acute Kidney Injury Using a Translational
In Vivo
Rat Model
Authors: Liu Jiajun , Pais Gwendolyn M. , Avedissian Sean N. , Gilchrist Annette , Lee Andrew , Rhodes Nathaniel J. , Hauser Alan R. , Scheetz Marc H. 
Published: February 2020

We investigated dose-fractionated polymyxin B (PB) on acute kidney injury (AKI). PB at 12 mg of drug/kg of body weight per day (once, twice, and thrice daily) was administered in rats over 72 h. The thrice-daily group demonstrated the highest KIM-1 increase (
P
= 0.018) versus that of the controls (
P
= 0.99) and histopathological damage (
P
= 0.013). A three-compartment model best described the data (bias, 0.
Renal nephroblastoma in a 10‐month‐old boxer
Authors: Richardson Stephanie 
Published: February 2020

A 10‐month‐old male entire Boxer dog was presented for weight loss and abdominal distension with a large mass palpable within the abdomen. A unilateral nephrectomy was performed for a large renal nephroblastoma (30‐cm diameter). The nephroblastoma was suspected stage I, with favourable histology (human Wilms tumour grading). No adjunctive chemotherapy was administered. The dog remains clinically well 27 months postnephrectomy. Renal nephroblastomas are rare canine neoplasms and reported survival time is variable. This case and other recent reports suggest that mean survival time may be longer than previously thought. Nephroblastomas should be considered as a differential in young dogs presenting with clinical signs of an abdominal space‐occupying lesion. The absence of azotaemia on a biochemical profile does not preclude significant renal pathology.
On the uncertainty principle in Rindler and Friedmann spacetimes
Authors: Schürmann Thomas 
Published: February 2020

AbstractWe revise the extended uncertainty relations for the Rindler and Friedmann spacetimes recently discussed by Dabrowski and Wagner in [9]. We reveal these results to be coordinate dependent expressions of the invariant uncertainty relations recently derived for general 3-dimensional spaces of constant curvature in [10]. Moreover, we show that the non-zero minimum standard deviations of the momentum in [9] are just artifacts caused by an unfavorable choice of coordinate systems which can be removed by standard arguments of geodesic completion.
Derived invariance of Crawley-Boevey’s H0-Poisson structure
Authors: Zeng Jieheng 
Published: February 2020

Crawley-Boevey introduced in [Poisson structure on moduli spaces of representations, J. Algebra 325 (2011) 205–215.], the notion of [Formula: see text]-Poisson structure for associative algebras, which is the weakest condition that induces a Poisson structure on the moduli spaces of their representations. In this paper, by using a result of Armenta and Keller in [Derived invariance of the Tamarkin-Tsygan calculus of an algebra, C. R. Math. Acad. Sci. Paris 357(3) (2019) 236–240.], we show that an [Formula: see text]-Poisson structure is preserved under derived Morita equivalence.
First photographic record of Jungle Cat Felis chaus Schreber, 1777 (Mammalia: Carnivora: Felidae) in Haripur District, Pakistan
Authors: Anjum Afzal , Appel Angie , Kabir Muhammad 
Published: February 2020

The Jungle Cat Felis chaus was recorded in Pakistan’s Haripur District during a camera trapping survey in March to April 2019. This is the first photographic evidence of its presence outside a protected area in northern Pakistan.
Variations in Friction Velocity with Wind Speed and Height for Moderate-to-Strong Onshore Winds Based on Measurements from a Coastal Tower
Authors: Fang Pingzhi , Jiang Wendong , Tang Jie , Lei Xiaotu , Tan Jianguo 
Published: February 2020

AbstractVariations in friction velocity with wind speed and height are studied under moderate (≥9 m s−1)-to-strong onshore wind conditions caused by three landfalling typhoons. Wind data are from a coastal 100-m tower equipped with 20-Hz ultrasonic anemometers at three heights. Results show that wind direction affects variations in friction velocity with wind speed. A leveling off or decrease in friction velocity occurs at a critical wind speed of ~20 m s−1under strong onshore wind conditions. Friction velocity does not always decrease with height in the surface layer under typhoon conditions. Thus, height-based corrections on friction velocities using the model from Anctil and Donelan may not be reliable. Surface-layer heights predicted by the model that are based on Ekman dynamics are verified by comparing with those determined by a proposed method that is based on the idea of mean boundary layer using wind-profile data from one of the landfalling typhoons. Friction velocity at the top of the surface layer is then estimated. Results show that friction velocity decreases by about 20% from its surface value and agrees well with previous results of Tennekes.
Are transient changes in capillary surface area required to explain peritoneal transport in renal failure patients?
Authors: Wolf Matthew B 
Published: February 2020

Background: Waniewski postulated a transient increase in peritoneal capillary surface area to fit their model predictions to experimental data of Heimburger measured in renal failure (RF) patients undergoing peritoneal dialysis (PD) but with only a 3.86% glucose dialysis fluid. The present aim is to propose a new mathematical model of the patient PD procedure that could closely fit the complete Heimburger measurement set without this postulate. Methods: The three-pore model of Rippe was used to describe transient changes in peritoneal volume and solute concentrations during a PD dwell. The predialysis, RF patient, plasma solute concentrations were assumed to remain constant during the dwell. The model was validated using the 3.86% glucose Heimburger measurements. Permeability surface area product parameters were chosen to match only the end-dwell peritoneal fluid glucose concentration and the end-dwell amounts of urea, creatinine, and Na+ removed from this simulated patient group. Then, this model was used to predict additional measurements by Heimburger on two other patient groups dialyzed with glucose concentrations of 2.27% and 1.36%, respectively. Parameters were unchanged when simulating these other patient groups. Results: To match the shape of the transient changes in drained volume and dialysis fluid glucose concentration for the 3.86% glucose group, it was necessary for only one parameter, the effective radius of glucose, to vary linearly in proportion to the dialysis fluid glucose concentration. This description was unchanged in the other two groups. Conclusion: Postulated transient increases in peritoneal capillary surface area were unnecessary to predict the entire Heimburger measurements.
Prospective growth and developmental outcomes in infants born to mothers with multiple sclerosis
Authors: Mahlanza Tatenda Dawn , Manieri Maria Claudia , Klawiter Eric C , Solomon Andrew J , Lathi Ellen , Ionete Carolina , Berriosmorales Idanis , Severson Christopher , Stankiewicz James , Cabot Ann , Elkort Michael , Chitnis Tanuja , Bove Riley , Katz Joshua , Houtchens Maria 
Published: February 2020

Background: The importance of supporting pregnancy-related decisions in multiple sclerosis (MS) patients has increasingly been recognized and hence the need for prospective data on pregnancy and pediatric outcomes in this patient population. Objective: To assess prospective growth and developmental outcomes of infants born to mothers with multiple sclerosis (IMS). Methods: PREG-MS is a prospective multicenter cohort study in New England, United States. We followed 65 women with MS and their infants with up to 12 months consistent pediatric follow-up. Pediatric, neurologic, and demographic information was obtained via structured telephone interviews and validated with medical records. Results: No differences in infant weights and lengths with World Health Organization (WHO) 50th percentile standards were observed ( p > 0.05). However, larger head circumference (HC) measurements than WHO standards were reported in cohort infants ( p < 0.05). There was no association between HC and markers of maternal MS activity, demographic, or social factors. No irreversible pediatric developmental abnormalities were observed. Conclusion: This first prospective study on pediatric anthropometry in IMS suggests a possible increase in HC compared to WHO standards without an increase in irreversible developmental abnormalities. The observations are exploratory and require confirmation with larger prospective studies in diverse groups of MS patients.
Adding new experimental arms to randomised clinical trials: Impact on error rates
Authors: Choodari-Oskooei Babak , Bratton Daniel J , Gannon Melissa R , Meade Angela M , Sydes Matthew R , Parmar Mahesh KB 
Published: February 2020

Background: Experimental treatments pass through various stages of development. If a treatment passes through early-phase experiments, the investigators may want to assess it in a late-phase randomised controlled trial. An efficient way to do this is adding it as a new research arm to an ongoing trial while the existing research arms continue, a so-called multi-arm platform trial. The familywise type I error rate is often a key quantity of interest in any multi-arm platform trial. We set out to clarify how it should be calculated when new arms are added to a trial some time after it has started. Methods: We show how the familywise type I error rate, any-pair and all-pairs powers can be calculated when a new arm is added to a platform trial. We extend the Dunnett probability and derive analytical formulae for the correlation between the test statistics of the existing pairwise comparison and that of the newly added arm. We also verify our analytical derivation via simulations. Results: Our results indicate that the familywise type I error rate depends on the shared control arm information (i.e. individuals in continuous and binary outcomes and primary outcome events in time-to-event outcomes) from the common control arm patients and the allocation ratio. The familywise type I error rate is driven more by the number of pairwise comparisons and the corresponding (pairwise) type I error rates than by the timing of the addition of the new arms. The familywise type I error rate can be estimated using Šidák’s correction if the correlation between the test statistics of pairwise comparisons is less than 0.30. Conclusions: The findings we present in this article can be used to design trials with pre-planned deferred arms or to add new pairwise comparisons within an ongoing platform trial where control of the pairwise error rate or familywise type I error rate (for a subset of pairwise comparisons) is required.
Designing clinical trials with (restricted) mean survival time endpoint: Practical considerations
Authors: Eaton Anne , Therneau Terry , Le-Rademacher Jennifer 
Published: February 2020

Background/aims: The difference in mean survival time, which quantifies the treatment effect in terms most meaningful to patients and retains its interpretability regardless of the shape of the survival distribution or the proportionality of the treatment effect, is an alternative endpoint that could be used more often as the primary endpoint to design clinical trials. The underuse of this endpoint is due to investigators’ lack of familiarity with the test comparing the mean survival times and the lack of tools to facilitate trial design with this endpoint. The aim of this article is to provide investigators with insights and software to design trials with restricted mean survival time as the primary endpoint. Methods: A closed-form formula for the asymptotic power of the test of restricted mean survival time difference is presented. The effects of design parameters on power were evaluated for the mean survival time test and log-rank test. An R package which calculates the power or the sample size for user-specified parameter values and provides power plots for each design parameter is provided. The R package also calculates the probability that the restricted mean survival time is estimable for user-defined trial designs. Results: Under proportional hazards and late differences in survival, the power of the mean survival time test can approach that of the log-rank test if the restriction time is late. Under early differences, the power of the restricted mean survival time test is higher than that of the log-rank test. Duration of accrual and follow-up have little influence on the power of the restricted mean survival time test. The choice of restriction time, on the other hand, has a large impact on power. Because the power depends on the interplay among the design factors, plotting the relationship between each design parameter and power allows the users to select the designs most appropriate for their trial. When modification is necessary to ensure the difference in restricted mean survival time is estimable, the three available modifications all perform adequately in the scenarios studied. Conclusion: The restricted mean survival time is a survival endpoint that is meaningful to investigators and to patients and at the same time requires less restrictive assumptions. The biggest challenge with this endpoint is selection of the restriction time. We recommend selecting a restriction time that is clinically relevant to the disease and the clinical setting of the trial of interest. The practical considerations and the R package provided in this work are readily available tools that researchers can use to design trials with restricted mean survival time as the primary endpoint.
Noninvasive Continuous Monitoring of Vital Signs With Wearables: Fit for Medical Use?
Authors: Jacobsen Malte , Dembek Till A. , Kobbe Guido , Gaidzik Peter W. , Heinemann Lutz 
Published: February 2020

Background: Wearables (= wearable computer) enable continuous and noninvasive monitoring of a range of vital signs. Mobile and cost-effective devices, combined with powerful data analysis tools, open new dimensions in assessing body functions (“digital biomarkers”). Methods: To answer the question whether wearables are ready for use in the medical context, a PubMed literature search and analysis for their clinical-scientific use using publications from the years 2008 to 2018 was performed. Results: A total of 79 out of 314 search hits were publications on clinical trials with wearables, of which 16 were randomized controlled trials. Motion sensors were most frequently used to measure defined movements, movement disorders, or general physical activity. Approximately 20% of the studies used sensors to detect cardiovascular parameters. As for the sensor location, the wrist was chosen in most studies (22.8%). Conclusion: Wearables can be used in a precisely defined medical context, when taking into account complex influencing factors.
Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis
Authors: Ong Kevin L. , Runa Maria , Xiao Zhimin , Ngai Wilson , Lau Edmund , Altman Roy D. 
Published: February 2020

Objective Concerns have been raised about severe acute localized reactions (SALR) following intra-articular (IA) hyaluronic acid (HA) injections for knee osteoarthritis (OA). We compared surrogate SALR measures between hylan G-F 20 and non-hylan G-F 20 HA patients and evaluated corresponding SALR risk factors for hylan G-F 20 patients. Design Knee OA patients were identified from the Optum Clinformatics dataset (January 2006 to June 2016), stratified into hylan G-F 20 and non-hylan G-F 20 HA users. Occurrences of surrogate SALR measures including inflammation/infection, intra-articular corticosteroid (CS) injections, arthrocentesis/aspiration, and office visits were evaluated within 3 days of HA use. Risk factors were evaluated using logistic regression. Results The cohort involved 748,428 HA patients (23.2% in the hylan G-F 20 group). Inflammation/infection rate was 0.001% for hylan G-F 20 and 0.002% for non-hylan G-F 20 HA groups. Risk of CS injection (any diagnosis) was greater for hylan G-F 20 patients by 28% ( P < 0.001). Combined rates of CS injection and arthrocentesis/aspiration (any diagnosis) were comparable for both groups (hylan G-F 20, 2.2%; non-hylan G-F 20 HA, 2.6%). The risk of any visit or studied responses was lower for the hylan G-F 20 cohort by 12% ( P < 0.001). Clinical characteristics, such as CS injections within 1 week before HA and fluoroscopic imaging, were associated with the outcomes. Conclusions The diagnosis of inflammations or infections within 3 days of the HA injection was extremely rare. The overall risk of surrogate SALR measures was similar for hylan G-F 20 and non-hylan G-F 20 HA patients.
Autism and attachment disorder symptoms in the general population: Prevalence, overlap, and burden
Authors: Minnis Helen , Messow Claudia-Martina , McConnachie Alex , Bradshaw Paul , Briggs Andrew , Wilson Philip , Gillberg Christopher 
Published: February 2020

Background: Co-occurring trauma-related and neurodevelopmental problems are common in maltreated children. In population research and clinical practice, these tend to be considered separately. Overlapping health problems, that is, “multi-morbidity,” in adulthood is associated with increased service burden and costs, but this has not been investigated in childhood. Methods: Using well-validated parent-report questionnaires, we examined the overlap between symptoms of the neurodevelopmental disorder autism (autism spectrum disorder, ASD) and symptoms of the trauma- and stressor-related disorders (reactive attachment disorder [RAD] and disinhibited social engagement disorder [DSED]) in a representative general population sample of over 3,300 children aged 5–6 years of age. We investigated sociodemographic factors, service burden, and costs in association with these problems when considered separately and when co-occurring. Results: Nearly 2% of this population had symptoms suggestive of both ASD and RAD/DSED. High symptom scores for ASD were associated with male gender, (younger) age of mother at birth, and being in a single-parent family, while high symptom scores for RAD/DSED were associated with (younger) age of mother at birth, being in a single-parent family, and the number of accidents reported. Service use costs per likely case of both ASD and RAD/DSED in the preschool years were increased by £348.62 (95% confidence interval 121.04–391.11)—nearly double the costs of ASD alone. Conclusions: There is considerable overlap between symptoms of ASD and RAD/DSED in the general population, indicating that multi-morbidity is already present in childhood and is associated with increased service use and costs even in the preschool years.
SPECS: a non-parametric method to identify tissue-specific molecular features for unbalanced sample groups
Authors: Everaert Celine , Volders Pieter-Jan , Morlion Annelien , Thas Olivier , Mestdagh Pieter 
Published: February 2020

Abstract
Background
To understand biology and differences among various tissues or cell types, one typically searches for molecular features that display characteristic abundance patterns. Several specificity metrics have been introduced to identify tissue-specific molecular features, but these either require an equal number of replicates per tissue or they can’t handle replicates at all.

Results
We describe a non-parametric specificity score that is compatible with unequal sample group sizes. To demonstrate its usefulness, the specificity score was calculated on all GTEx samples, detecting known and novel tissue-specific genes. A webtool was developed to browse these results for genes or tissues of interest. An example python implementation of SPECS is available at https://github.com/celineeveraert/SPECS. The precalculated SPECS results on the GTEx data are available through a user-friendly browser at specs.cmgg.be.

Conclusions
SPECS is a non-parametric method that identifies known and novel specific-expressed genes. In addition, SPECS could be adopted for other features and applications.