bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced Lysosomal Acid Lipase Activity in Blood and Platelets Is Associated With Nonalcoholic Fatty Liver Disease
Authors: Ferri Flaminia , Mischitelli Monica , Tozzi Giulia , Messina Emanuele , Mignini Irene , Mazzuca Sergio , Pellone Monica , Parisse Simona , Marrapodi Ramona , Visentini Marcella , Baratta Francesco , Del Ben Maria , Pastori Daniele , Perciballi Roberta , Attilia Maria Luisa , Carbone Martina , De Santis Adriano , Violi Francesco , Angelico Francesco , Ginanni Corradini Stefano 
Published: February 2020

OBJECTIVES:
To investigate whether blood total lysosomal acid lipase activity (BT-LAL) levels are uniquely associated with the noncirrhotic and cirrhotic stages of nonalcoholic fatty liver disease (NAFLD) and with protection from NAFLD in metabolically/genetically predisposed subjects and a normal liver. To clarify which enzyme-carrying circulating cells are involved in reduced BT-LAL of NAFLD.

METHODS:
In a cross-sectional study, BT-LAL was measured by a fluorigenic method in patients with NAFLD (n = 118), alcoholic (n = 116), and hepatitis C virus-related disease (n = 49), in 103 controls with normal liver and in 58 liver transplant recipients. Intracellular platelet and leukocyte LAL was measured in 14 controls and 28 patients with NAFLD.

RESULTS:
Compared with controls, (i) BT-LAL and LAL in platelets, but not in leukocytes, were progressively reduced in noncirrhotic NAFLD and in nonalcoholic steatohepatitis-related cirrhosis; (ii) platelet and leukocyte counts did not differ in patients with noncirrhotic NAFLD; and (iii) BT-LAL did not differ in alcoholic and hepatitis C virus noncirrhotic patients. BT-LAL progressively increased in controls with metabolic syndrome features according to their PNPLA3 rs738409 steatosis-associated variant status (II vs IM vs MM), and their BT-LAL was higher than that of noncirrhotic NAFLD, only when carriers of the PNPLA3 unfavorable alleles were considered. Liver transplant recipients with de novo NAFLD compared with those without de novo NAFLD had lower BT-LAL.

DISCUSSION:
LAL in blood and platelets is progressively and uniquely reduced in NAFLD according to disease severity. High BT-LAL is associated with protection from NAFLD occurrence in subjects with metabolic and genetic predisposition. Low LAL in platelets and blood could play a pathogenetic role in NAFLD.
Oxyntomodulin May Distinguish New-Onset Diabetes After Acute Pancreatitis From Type 2 Diabetes
Authors: Bharmal Sakina H. , Cho Jaelim , Stuart Charlotte E. , Alarcon Ramos Gisselle C. , Ko Juyeon , Petrov Maxim S. 
Published: February 2020

OBJECTIVE:
New-onset diabetes is an important sequela of acute pancreatitis, but there are no biomarkers to differentiate it from the much more common type 2 diabetes. The objective was to investigate whether postprandial circulating levels of gut hormones can serve this purpose.

METHODS:
This was a case-control study nested into a prospective longitudinal cohort study that included 42 insulin-naive cases with new-onset prediabetes/diabetes after acute pancreatitis (NODAP) and prediabetes/diabetes followed by acute pancreatitis (T2D-AP), sex matched with 21 healthy controls. All individuals underwent a standardized mixed-meal test, and blood samples were assayed for gut hormones (glucose-dependent insulinotropic peptide, glucagon-like peptide-1, oxyntomodulin, and peptide YY). Analysis of variance and linear regression analysis were conducted in unadjusted and adjusted models (accounting for age, homeostatic model assessment of β-cell function, and magnetic resonance imaging–derived body fat composition).

RESULTS:
Oxyntomodulin levels were significantly lower in NODAP compared with T2D-AP and healthy controls (P = 0.027 and P = 0.001, respectively, in the most adjusted model). Glucagon-like peptide-1 and peptide YY were significantly lower in NODAP compared with T2D-AP (P = 0.001 and P = 0.014, respectively, in the most adjusted model) but not compared with healthy controls (P = 1.000 and P = 0.265, respectively, in the most adjusted model). Glucose-dependent insulinotropic peptide levels were not significantly different between NODAP and T2D-AP.

DISCUSSION:
Oxyntomodulin is a promising biomarker to guide the differential diagnosis of new-onset diabetes after acute pancreatitis. However, external validation studies are warranted before it can be recommended for routine use in clinical practice.
Methamphetamine Learning Induces Persistent and Selective Nonmuscle Myosin II-Dependent Spine Motility in the Basolateral Amygdala
Authors: Young Erica J. , Lin Hua , Kamenecka Theodore M. , Rumbaugh Gavin , Miller Courtney A. 
Published: February 2020

Nonmuscle myosin II inhibition (NMIIi) in the basolateral amygdala (BLA), but not dorsal hippocampus (CA1), selectively disrupts memories associated with methamphetamine (METH) days after learning, without retrieval. However, the molecular mechanisms underlying this selective vulnerability remain poorly understood. A known function of NMII is to transiently activate synaptic actin dynamics with learning. Therefore, we hypothesized that METH-associated learning perpetuates NMII-driven actin dynamics in synapses, leading to an extended window of vulnerability for memory disruption. We used time-lapse two-photon imaging of dendritic spine motility in acutely prepared brain slices from female and male mice following METH-associated learning as a readout of actin–myosin dynamics. Spine motility was persistently increased in the BLA, but not in CA1. Consistent with the memory disrupting effect of intra-BLA NMII inhibition, METH-induced changes to BLA spine dynamics were reversed by a single systemic injection of an NMII inhibitor. Intra-CA1 NMII inhibition, on the other hand, did not disrupt METH-associated memory. Thus, we report identification of a previously unknown ability for spine actin dynamics to persist days after stimulation and that this is under the control of NMII. Further, these perpetual NMII-driven spine actin dynamics in BLA neurons may contribute to the unique susceptibility of METH-associated memories.SIGNIFICANCE STATEMENTThere are no Food and Drug Administration-approved pharmacotherapies to prevent relapse to the use of stimulants, such as methamphetamine (METH). Environmental cues become associated with drug use, such that the memories can elicit strong motivation to seek the drug during abstinence. We previously reported that the storage of METH-associated memories is uniquely vulnerable to immediate, retrieval-independent, and lasting disruption by direct actin depolymerization or by inhibiting the actin driver nonmuscle myosin II (NMII) in the BLA or systemically. Here we report a potential structural mechanism responsible for the unique vulnerability of METH-associated memories and METH-seeking behavior to NMII inhibition within the BLA.
Astrocytic YAP Promotes the Formation of Glia Scars and Neural Regeneration after Spinal Cord Injury
Authors: Xie Changnan , Shen Xiya , Xu Xingxing , Liu Huitao , Li Fayi , Lu Sheng , Gao Ziran , Zhang Jingjing , Wu Qian , Yang Danlu , Bao Xiaomei , Zhang Fan , Wu Shiyang , Lv Zhaoting , Zhu Minyu , Xu Dingjun , Wang Peng , Cao Liying , Wang Wei , Yuan Zengqiang , Wang Ying , Li Zhaoyun , Teng Honglin , Huang Zhihui 
Published: February 2020

Yes-associated protein (YAP) transcriptional coactivator is negatively regulated by the Hippo pathway and functions in controlling the size of multiple organs, such as liver during development. However, it is not clear whether YAP signaling participates in the process of the formation of glia scars after spinal cord injury (SCI). In this study, we found that YAP was upregulated and activated in astrocytes of C57BL/6 male mice after SCI in a Hippo pathway-dependent manner. Conditional knockout (KO) ofyapin astrocytes significantly inhibited astrocytic proliferation, impaired the formation of glial scars, inhibited the axonal regeneration, and impaired the behavioral recovery of C57BL/6 male mice after SCI. Mechanistically, the bFGF was upregulated after SCI and induced the activation of YAP through RhoA pathways, thereby promoting the formation of glial scars. Additionally, YAP promoted bFGF-induced proliferation by negatively controlling nuclear distribution of p27Kip1mediated by CRM1. Finally, bFGF or XMU-MP-1 (an inhibitor of Hippo kinase MST1/2 to activate YAP) injection indeed activated YAP signaling and promoted the formation of glial scars and the functional recovery of mice after SCI. These findings suggest that YAP promotes the formation of glial scars and neural regeneration of mice after SCI, and that the bFGF-RhoA-YAP-p27Kip1pathway positively regulates astrocytic proliferation after SCI.SIGNIFICANCE STATEMENTGlial scars play critical roles in neuronal regeneration of CNS injury diseases, such as spinal cord injury (SCI). Here, we provide evidence for the function of Yes-associated protein (YAP) in the formation of glial scars after SCI through regulation of astrocyte proliferation. As a downstream of bFGF (which is upregulated after SCI), YAP promotes the proliferation of astrocytes through negatively controlling nuclear distribution of p27Kip1mediated by CRM1. Activation of YAP by bFGF or XMU-MP-1 injection promotes the formation of glial scar and the functional recovery of mice after SCI. These results suggest that the bFGF-RhoA-YAP-p27Kip1axis for the formation of glial scars may be a potential therapeutic strategy for SCI patients.
KOMPOSISI HASIL TANGKAPAN DAN DAERAH PENANGKAPAN PANCING ULUR TUNA DI PERAIRAN SENDANG BIRU
Authors: Agustina Maya , Jatmiko Irwan , Sulistyaningsih Ririk Kartika 
Published: February 2020

Tuna, cakalang dan tongkol (TCT) merupakan jenis hasil tangkapan ikan yang memiliki nilai ekonomis penting dan masih terdapat peluang untuk dimanfaatkan. Salah satu sentra perikanan tuna, cakalang dan tongkol di kawasan Indonesia Barat yang terbesar adalah di Kabupaten Malang tepatnya di Pelabuhan Perikanan Pantai (PPP) Pondokdadap Sendang Biru. Jenis alat penangkapan ikan yang digunakan oleh nelayan untuk menangkap tuna di perairan ini adalah pancing ulur (handline) yang dioperasikan dengan menggunakan bantuan rumpon. Tujuan penelitian ini adalah untuk mengetahui informasi sebaran daerah penangkapan (teritorial, ZEE dan laut lepas) dan bagaimana dinamika hasil tangkapannya khususnya tuna, cakalang dan tongkol. Pancing ulur mendominasi alat penangkapan ikan yang digunakan di PPP Pondokdadap, Sendang Biru tercatat sebanyak 70,42%, sedangkan pukat cincin sebanyak 9,82% dan pancing rawai sebanyak 19,76%. Jenis hasil tangkapan pancing ulur terbanyak adalah cakalang dan juwana tuna. Daerah penangkapan nelayan pancing ulur yang berbasis di PPP Pondokdadap, Sendang Biru menyebar pada kawasan perairan dengan batasan antara 8º – 12º LS dan 108º – 115º BT atau secara geografis berada di dalam perairan teritorial, ZEE dan di laut lepas. Prosentase hasil tangkapan TCT yang tertangkap pancing ulur berdasarkan wilayah perairan seperti berikut: teritorial sebanyak 0,63%, ZEE sebanyak 78,68% dan di luar ZEE (laut lepas) sebanyak 20,69%. Tuna, skipjack and little tuna are economically important and still has the potential to cathed. One of the fisheries centers tuna, skipjack and little tuna landing site in the western part of Indonesia is in Malang located at Pondokdadap Sendang Biru fishing port. The fishing gear commonly used by Sendang Biru fishermen to catch tuna in the Indian Ocean waters is handline which is operated around FADs. The purpose of this study was to find out information the distribution of fishing areas (territorial, EEZ and high seas) and how the dynamics of the catch especially tuna, skipjack and little tuna. The dominant fishing gear in PP Pondokdadap Sendang Biru is the handline with 70.42%, followed by purse seine 9.82% and longlines 19.76%. The dominant catches caught by handline were skipjack and juvenile of yellowfin tuna. Fishing ground of hand line based in PP Pondokdadap located in waters with boundaries between 8º - 12º LS and 108º - 115ºBT or geographically located in the waters territorial, EEZ and on the high seas. Tuna catches precentage caught by handline in territorial, EEZ and high seas, accounting for 0.63%, 78.68% and 20.69%, respectively.
Characteristics of Heart Failure Patients based on Its Causes in Camelia Hospitalization Room Dr. Soetomo General Hospital Surabaya January - December 2017
Authors: Tobing Chronica Elsa Retta Lumban , Dharmadjati Budi Baktijasa , Soebroto Heroe 
Published: February 2020

Introduction: Heart failure is one of cardiovascular diseases which becomes a global health problem, especially in Indonesia. It’s a clinical syndrome caused by variety of underlying diseases. Different causes that cause heart failure in patients will certainly lead to different manifestations and outcomes. Methods: This research was a descriptive study using secondary data taken from the patient's medical records. The number of samples in this study were 197 patients with heart failure in Camelia Hospitalization Room Dr. Soetomo General Hospital Surabaya. Sampling technique was total sampling. The variables were age, sex, stage, symptoms, physical examination, and pharmacological treatment. The data were analyzed descriptively. Results: Most heart failure causes in this hospital was coronary heart disease (40.6%). Patients aged 46-65 years old and male patients were more dominant although the difference was not really significant. Male patients were dominant in heart failure due to coronary heart disease and hypertension, meanwhile female patients were dominant in heart valve disease and other causes. Most patients in all causes of heart failure were diagnosed at advanced stage, such as stage III (35.5%) and stage IV (35.5%). Main symptom that was found more in the patients was dyspnea (70.1%), which could be found in coronary & heart valve disease. Physical examination results were based on the causes. Most pharmacological treatments that the patients had were Furosemide (88.3%) and Spironolactone (73.6%). Conclusion: Coronary heart disease still becomes the main cause of heart failure. Heart failure was more common in early and late elderly (46-65 years old), with male patients were more dominant. More patients were diagnosed at advanced stage. Symptom that was found more was dyspnea. Physical examination results were various based on its causes. Pharmacological treatments that the patients had gotten were Furosemide, kind of diuretics, and Spironolactone, kind of aldosterone antagonist.
DINAMIKA KEBIJAKAN PENGEMBANGAN BIODIESEL BERBAHAN BAKU KELAPA SAWIT INDONESIA
Authors: Rambe Khoiru Rizqy , Kusnadi Nunung , Suharno Suharno 
Published: February 2020

Indonesia develops palm oil biodiesel driven by mandatory biodiesel which requires the use of biodiesel as a mixture of fuel oil by 30 percent. However, the development of the biodiesel can cause a trade off CPO for the production of biodiesel and palm cooking oil. The purpose of this study is to analyze the achievement of Indonesia's biodiesel production, and formulate policies for the development of the biodiesel industry with consideration of the balance of the food and non-food sectors. The data used are secondary data obtained from various related agencies such as the Central Bureau of Statistics, Ministry of Agriculture, BAPPEBTI, World Bank and other institutions related to this research which are analyzed by dynamic system models. The results of the analysis show that the development of Indonesian biodiesel has not been able to meet the level of the blending rate according to mandatory biodiesel. Efforts to increase the achievement of the blending rate level can be done by providing biodiesel subsidies. Export duty policy is also needed in an effort to maintain the stability of domestic CPO prices and the price of palm cooking oil. The export duty policy in accordance with Minister of Finance Regulation No. 136 of 2015 is more effectively implemented than Minister of Finance Regulation No. 140 of 2016. Keywords : blending rate, dynamic system, mandatory biodiesel, policy scenario
Perbandingan Model Kooperatif Learning Tipe Student Team Achievement Division Dengan Model Kooperatif Learning Tipe Numbered Head Together Terhadap Hasil Belajar Siswa Pada Mata Pelajaran Simulasi Digital Kelas X Multimedia Di SMK Taruna Bhakti
Authors: Zaini Bachren , Swandani Rizky 
Published: February 2020

Penelitian ini bertujuan untuk mengetahui perbandingan model pembelajaran Student Team Achivement Division (STAD) dengan model pembelajaran Kooperatif Learning tipe Numbered Head Together (NHT) terhadap hasil belajar siswa pada mata pelajaran Simulasi Digital. Penelitian dilakukan di SMK Taruna Bhakti Depok, dilaksanakan pada bulan April - Mei 2016. Model Student Team Achivement Division (STAD) merupakan model pembelajaran yang menerapkan siswa lebih aktif dan guru hanya sebagai fasilitator. Penelitian ini menggunakan metode quasy eksperimental, diberikan perlakuan terhadap kedua kelas dengan berbeda perlakuan. Masing â€“ Masing kelas terdiri dari 40 siswa. Pengambilan sampel menggunakan teknik purposive sampling. Untuk kelas eksperimen diterapkan di kelas X Multimedia 1 dan untuk kelas kontrol diterapkan di kelas X TKJ 3, untuk mendapatkan data penelitian ini menguji siswa dengan tes awal dan tes akhir untuk mengukur kemampuan kognitif dengan tes pilihan ganda. hasil penelitian yang diterapkan Student Team Achivement Division (STAD) mendapatkan nilai rata-rata 83,98, sedangkan siswa yang diterapkan model Kooperatif Learning tipe Numbered Head Together (NHT) mendapatkan nilai rata-rata 78,55, sehingga dapat disimpulkan hasil belajar simulasi digital antara yang diajarkan menggunakan model Student Team Achivement Division (STAD) lebih tinggi dibandingkan dengan yang diajarkan menggunakan model Kooperatif Learning tipe Numbered Head Together (NHT).
Management of a Broken PRECICE Femoral Nail at an Ununited Distraction Osteogenesis Site
Authors: Hidden Krystin A. , Dahl Mark T. , Ly Thuan V. 
Published: February 2020

Case:
A 20-year-old man with a history of right lower extremity fibular hemimelia previously treated with PRECICE femoral nail lengthening presented with a broken magnetic nail and a displaced fracture through an ununited distraction osteogenesis site. Using a combination of techniques, we removed the broken implant while maintaining the achieved limb length and preserving the native biology without bone grafting.

Conclusion:
The unique challenges associated with the removal of a broken PRECICE femoral nail are described, with a technique for implant removal that preserves the achieved length, the innate biology of the distraction osteogenesis site, and promoting union without bone grafting.
Giant Seromal Cyst Development After Tourniquet Use During Total Knee Arthroplasty
Authors: van Erp Joost H.J. , de Gast Arthur , Bruekers Sven E. , Bekkers Joris E.J. 
Published: February 2020

Case:
An 84-year old woman developed 2 large seromal cysts at the medial side of her right thigh, 4 months after total knee arthroplasty (TKA). The cysts were located at the place where the tourniquet, during surgery, had been applied. The diagnosis was confirmed with echography and magnetic resonance imaging. Both cysts were resected, and the patient recovered completely, after one relapse in which a lymphatic vessel was sutured.

Conclusion:
Development of seromal cyst after tourniquet use during TKA is a rare but serious complication.
Revisiting the Sample Size and Statistical Power of Randomized Controlled Trials in Orthopaedics After 2 Decades
Authors: Reito Aleksi , Raittio Lauri , Helminen Olli 
Published: February 2020

Background:
A study published in 2001 reported that sample sizes in the randomized controlled trials (RCTs) published in major orthopaedic journals in 1997 were too small, resulting in low power to detect reasonable effect sizes. Low power is the fundamental reason for the poor reproducibility of research findings and serves to erode a cornerstone of the scientific method. The aim of this study was to ascertain whether improvements have been made in orthopaedic research during the past 2 decades.

Methods:
The electronic table of contents from the 2016 and 2017 volumes of 7 major orthopaedic journals were searched issue by issue in chronological order to identify possible RCTs. A posteriori (after-the-fact) power to detect small, medium, and large effect sizes, defined by the Cohen d value, were calculated from the sample sizes reported in the studies. The power to detect effect sizes associated with the most commonly used patient-reported outcome measures (PROMs) was also calculated. Finally, the use of a priori power analysis in the included studies was assessed.

Results:
In total, 233 studies were included in the final analyses. None of the negative studies had sufficient power (≥0.80) to detect a small effect size. Only between 15.0% and 32.1% of the negative studies had adequate power to detect a medium effect size. When categorized by anatomic region, 0% to 52.6% had adequate power to detect an effect size corresponding to the minimal clinically important difference (MCID). An a priori power analysis was employed in 196 (84%) of the 233 studies. However, the power analysis could not be replicated in 46% of the studies that used a mean comparison.

Conclusions:
Although small improvements in orthopaedic RCTs have occurred during the past 2 decades, many RCTs are still underpowered: the sample sizes are still too small to have adequate power to detect what would be deemed clinically relevant.
KONSEP HUTANG-PIUTANG DALAM Al-QUR’AN
Authors: Musadad Ahmad 
Published: February 2020

Manusia adalah makhluk sosial yang membutuhkan orang lain dalam memnuhi kebutuhannya. Manusia juga makhluk lemah yang tidak akan sempurna dalam mempertahankan kehidupan tanpa bantuan dan peranan orang lain dalam hidupnya. Tentunya hal semacam ini berlaku dalam segala hal, termasuk dalam pemenuhan rezeki. Banyak cara yang dilakukan Allah SWT. dalam menyampaikan rezeki pada hamba-Nya. Diantaranya adalah melalui disyariatkannya praktik transaksi hutang piutang sebagai salah satu aspek pemenuhan hajat hidup manusia. Dalam tulisan ini, penulis berusaha mengupas tafsir al-Qur’an terkait masalah hutang piutang ini, yaitu surat al-Baqarah ayat 282. Metode yang digunakan dalam menganalisis tafsir ayat di atas adalah metode tafsir maudlu‟i (tematik) dekan pola analisa studi komparatif kitab tafsir al-Maraghi karya Mustafa Al-Maraghi dan tafsir Al-Mishbah karya ulama Indonesia yaitu Prof. Dr. M Quraisy Shihab. Kedua kitab tersebut sangat populer dan menjadi rujukan umat Islam dalam menggali dan memahami pesan ayat suci.