bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult Inactivation of the Recessive Polycystic Kidney Disease Gene Causes Polycystic Liver Disease
Authors: Besse Whitney , Roosendaal Charlotte , Tuccillo Luigi , Ghosh Roy Sounak , Gallagher Anna-Rachel , Somlo Stefan 
Published: September 2020

Background
A major difference between autosomal recessive polycystic kidney disease (ARPKD) and autosomal dominant polycystic kidney disease (ADPKD) lies in the pattern of inheritance, and the resultant timing and focality of cyst formation. In both diseases, cysts form in the kidney and liver as a consequence of the cellular recessive genotype of the respective disease gene, but this occurs by germline inheritance in ARPKD and somatic second hit mutations to the one normal allele in ADPKD. The fibrocystic liver phenotype in ARPKD is attributed to abnormal ductal plate formation because of the absence of PKHD1 expression during embryogenesis and organ development. The finding of polycystic liver disease in a subset of adult PKHD1 heterozygous carriers raises the question of whether somatic second hit mutations in PKHD1 in adults may also result in bile duct-derived cyst formation.

Methods
We used an adult-inducible Pkhd1 mouse model to examine whether Pkhd1 has a functional role in maintaining bile duct homeostasis after normal liver development.

Results
Inactivation of Pkhd1 beginning at 4 weeks of age resulted in a polycystic liver phenotype with minimal fibrosis at 17 weeks. Increased biliary epithelium, which lines these liver cysts, was most pronounced in female mice. We assessed genetic interaction of this phenotype with either reduced or increased copies of Pkd1, and found no significant effects on the Pkhd1 phenotype in the liver or kidney from altered Pkd1 expression.

Conclusions
Somatic adult inactivation of Pkhd1 results in a polycystic liver phenotype. Pkhd1 is a required gene in adulthood for biliary structural homeostasis independent of Pkd1. This suggests that PKHD1 heterozygous carrier patients can develop liver cysts after somatic mutations in their normal copy of PKHD1.
Sustainable Solutions for Better Public Road Transportation
Authors: Saleena Beevi S , Pradeep Kumar B 
Published: September 2020

Transportation undoubtedly fastens economic growth by providing ways to initiate various modes. Population explosion, industrialization, and urbanization created more challenges to environmental stability. Urban transport is one of the essential components of urban development. Sustainable transportation includes the most efficient and convenient movement of people and vehicles with the least amount of energy, congestion, and environmental impacts. Therefore proper sustainable transport solutions are needed to pace with the developmental process. The paper attempts to provide some solutions that can ensure better human health and protection of the environment. These solutions include minimizing toxic gas emissions, electro mobility, road traffic management, congestion pricing, better parking policies, etc. These ecofriendly modes can improve the quality of public road transport and human life.
The Effectiveness of Using Language Arts in the English Language Curriculum to Teach Pronunciation and Vocabulary among Year One Students in One Semi Urban School in Malaysia
Authors: Shanmugavelu Ganesan , RK Sundaram Malar Arasi 
Published: September 2020

The English Language curriculum in Malaysia is using Language Arts to teach English. Language arts is a new component designed to create appreciation and enjoyment amongst pupils as they learn the language. This fun-filled and innovative section in the new English Curriculum is a great experience and used as well as a means to create confidence in pupils to use the language without inhibitions. The focus here is the use of language arts to teach pronunciation of words and understanding the meaning of the words better among the Year One students in a semi-urban school. Therefore the research has attempted to study the effectiveness of using songs to teach pronunciation and vocabulary among these students, as compared to using the traditional method, drilling, to teach pronunciation and vocabulary.
Questioning Techniques and Teachers’ Role in the Classroom
Authors: Shanmugavelu Ganesan , Ariffin Khairi , Vadivelu Manimaran , Mahayudin Zulkufli , R K Sundaram Malar Arasi 
Published: September 2020

The aim of this study is to discuss the efficacy of questioning techniques of the teachers in the classroom. Proper questioning techniques are important in the teaching and learning process. Proper questioning techniques will make it easier for teachers to get feedback from students whether or not they understand the subject. This article describes some of the questioning techniques that a teacher needs to know to possess in classroom teaching and learning sessions such as attention, suitable voice. Pause, question content, and distribution of questions. This is important for enhancing student motivation and promoting positive, critical, and creative thinking among students and to improve the teaching and learning process in the classroom.
Teaching Competencies of Upper Primary Teachers in Framing FA (a) Activities of CCE
Authors: Rajakumari C , Pazhanivelu G 
Published: September 2020

The aim of the study was to find out the difference between teaching competencies of upper primary teachers in framing FA (a)activities of CCE in terms of gender, locality, marital status, residence, age, the medium of instruction, type of school, nature of school and experience. The investigator adopted a survey method on analyzing teaching competencies of 900 upper primary teachers selected Theni district using a random sampling technique. Teaching competency fivepoint rating scale consisted of 25 statements with 5 point scale developed by the researcher based on the assessment competencies (Prior instructions to activities, instructions during activities, and instructional treatment after the activities) was used to collect data. Mean, SD, ‘t’ test, and ‘F’ test were used as statistical techniques for data analysis. The findings of the study revealed thatthere was no significant difference between the teaching competency of upper primary teachers’ in framing FA (a) activities of CCE in terms of gender, locality, marital status, residence, age, and medium of instruction. Still, they differed significantly in terms of the type of school, nature of the school, and experience.
KLUSTERISASI OPTIMAL DENGAN ELBOW METHOD UNTUK PENGELOMPOKAN DATA KECELAKAAN LALU LINTAS DI KOTA SEMARANG
Authors: Ekasetya Vada Annisa , Jananto Arief 
Published: September 2020

Kota Semarang merupakan kota metropolitan terbesar ke-5 se-Indonesia dengan angka kecelakaan lalu lintas yang dapat dikatakan tinggi. Dalam laporan tahunan Satlantas Kota Semarang dari tahun 2017, 2018 berurutan telah terjadi sebanyak 936 kasus dan 1.008 kasus. Kemudian pada tahun 2019 dengan hasil rekap sampai dengan bulan Agustus terjadi sebanyak 909 kasus.
Untuk mengetahui pola kecelakaan dalam mengolah data Laka Lantas dapat menggunakan sebuah metode penambangan data yang disebut data mining. Menggunakan teknik clustering dengan algoritma K-Means untuk menghasilkan pola dalam ekstraksi informasi, yang dikombinasikan dengan teknik optimasi kluster yaitu metode Elbow.
Penelitian ini menggunakan proses uji coba manual dan aplikasi RStudio. Perhitungan manual menggunakan uji coba jumlah K=2 sampai K=10 dengan penerapan metode Elbow menggunakan perhitungan nilai SSE (Sum of Square Error) pada tiap kluster. Pada grafik selisih SSE tiap kluster menunjukan patahan siku pada jumlah K=3. Perhitungan komputasi dengan aplikasi RStudio menghasilkan grafik selisih SSE dengan patahan siku pada jumlah K=3. Kemudian dengan menggunakan jumlah K=3 diimplementasikan kedalam Algoritma K-Means pada RStudio. Berdasarkan analisis yang dilakukan dengan data Laka Lantas periode bulan Oktober 2018 sampai bulan Juli 2019 menghasilkan tiga segmentasi data.
PIJAT REFLEKSI BERPENGARUH TERHADAP TEKANAN DARAH PADA PASIEN HIPERTENSI DI KLINIK ATGF 8 PALEMBANG
Authors: Lukman Lukman , Putra Sumitro Adi , Habiburrahma Elba , Wicaturatmashudi Sukma , Sulistini Rumentalia , Agustin Ismar 
Published: September 2020

Latar belakang: Hipertensi sering disebut sebagai pembunuh yang tidak diketahui, karena penderita tidak tahu bahwa dirinya menderita hipertensi. Banyak macam terapi komplementer yang dapat diterapkan untuk mengobati hipertensi, salah satunya pijat refleksi.
Metode: Penelitian ini bertujuan untuk mengetahui pengaruh pijat refleksi terhadap tekanan darah pada pasien hipertensi di Klinik ATFG-8 Palembang. Desain yang digunakan pada penelitian ini adalah pra-eksperimen dengan menggunakan rancangan one group pre-test post-test. Sampel pada penelitian ini adalah keseluruhan pasien hipertensi yang tidak mengkonsumsi obat penurun tekanan darah dan berkunjung untuk melakukan terapi pijat refleksi pada bulan 17 April s.d 17 Mei 2018. Penentuan sampel dengan metode purposive sampling sebanyak 18 subjek penelitian.
Hasil: Hasil yang diperoleh adalah rata-rata usia sampel 54,22 tahun (± 7,216), tekanan darah sistolik sebelum 148,44 mmHg (± 4,527) dan setelah pijat refleksi 143,78 mmHg (± 8,633). Hasil paired sample T test menunjukkan efek pijat refleksi pada tekanan darah sistolik (p = 0,026) dan diastolik (p = 0,001)
Kesimpulan: Terjadi penurunan tekanan darah secara statistik, namun secara substansi tidak bermakna. Peneliti berikutnya diharapkan untuk melakukan penelitian lebih lanjut dengan menambahkan sampel dan menggunakan kelompok kontrol.
EFEKTIVITAS PIJAT BAYI TERHADAP PENINGKATAN KUALITAS TIDUR BAYI
Authors: Sukmawati Ellyzabeth , Nur Imanah Norif Didik 
Published: September 2020

Tidur merupakan salah satu faktor yang mempengaruhi pertumbuhan bayi. Peningkatan kualitas tidur bayi dapat dilakukan melalui pijatan yang dilakukan orang tua. Tujuan penelitian ini adalah untuk mengetahui efektivitas pijat bayi terhadap peningkatan kualitas tidur bayi. Metode penelitian yang digunakan dalam penelitian ini adalah pre eksperimental dengan pendekatan pretest posttest one group design. Penelitian ini dilakukan di bidan praktik mandiri Emy Winarni Kesugihan Cilacap. Dalam penelitian ini yang menjadi populasi adalah ibu bayi yang berjumlah 30 bayi dengan menggunakan teknik sampling total population. Hasil penelitian ini adalah Terdapat efektivitas pijat bayi terhadap peningkatan kualitas tidur bayi dibuktikan dengan responden yang mengalami peningkatan kualitas tidur sebagian besar (73,33%) responden mempunyai kualitas tidur yang baik..
УДОСКОНАЛЕНИЙ МЕТОД ЕЛАСТОГРАФІЇ КРОВОНОСНИХ СУДИН
Authors: Витвицька Л.А.  , Лаврук Х.З.  , Чуйко М.М.  , Витвицький З.Я.  
Published: September 2020

Проведено аналіз існуючих методів ультразвукового контролю людського організму. Обґрунтовано доцільність проведення еластографії сонних артерій з метою діагностики атеросклерозу і ступеня нерухомості атеросклеротичних бляшок у судинах. Теоретично обґрунтовано доцільність проведення еластографії з використанням зсувних хвиль, які виникають при застосуванні радіаційного тиску сильного сфокусованого ультразвукового імпульсу. Розроблено конструкцію електронного ультразвукового сканера, який забезпечує високу чутливість прийнятих сигналів на різних глибинах з високою роздільною здатністю. Визначено параметри ультразвукових датчиків, розроблена методика проведення дослідження, яка забезпечує проведення контролю на різних глибинах, показано приклад проведення еластографії сонних артерій.
Warm Compress Of Pain Level In Patients Elderly Who Suffers Rematic
Authors: Firdaningsih  , Amirullah  , Amin A.Nurlaela 
Published: September 2020

The background based on data found at the society health center of Bontonyeleng, district of Gantarang, the regency of Bulukumba.it received 45 rheumatic patients in 2017. The aim of this research is to find out the influence of warm compress to decrease the pain degree of rheumatic patients qat society health center of Bontonyeleng, district of Gantarang, the regency of Bulukumba. The method has taken in this research was experimental research ( pre-experimental design) using the one-group pretest-posttest design. The population sample in this research was 30 respondent, it was taken using shack formula. Data analyse result using T-test match with value p 0,000. the research result gained before applying warm compress ton lo pain degree patients are 2 respondents or (6.7%) medium paint degree patient is 28 respondents or (93,3). While the result after applying a warm compress for low pain degree patients is 20 respondents or (66.7%) medium pain degree patient is 10 respondents or (33.3%). Based on explanations above, we can conclude that there is the influence of warm compress to decrease pain degree for the rheumatic patient especially for old society at society heald center of Bontonyeleng, district of Gantarang, the regency of Bulukumba so that is why people in bukit harapan village, district of Gantarang, regency of Bulukumba suggests for those who feel the pain that indicates rheumatic should not ignore and do an action like applying warm compress immediately using correct tools to decrease the pain or doing health check as soon as possible to nearby medical care.
Elaboração, caracterização físico-química e microbiológica de bebida alcoólica fermentada de cajarana (Spondias dulcis)
Authors: Lopes Yasmin Martins dos Santos , Souza Sara Helayne Silva de , Silva Jean Santos , Amador Erlon Silva , Sousa Deyse Dayan Freitas de , Modesto Junior Elivaldo Nunes 
Published: September 2020

A cajarana (Spondias dulcis) é uma fruta exótica originária das Ilhas da Polinésia, predominante no território brasileiro e possui um amplo potencial para ser explorado industrialmente. As bebidas fermentadas de frutas constituem produtos com perspectiva promissora de consumo, acessíveis e apreciadas por um grande público. Sendo assim o objetivo desse estudo foi produzir uma bebida alcoólica fermentada de cajarana, bem como determinar as características físico-químicas da bebida. A bebida foi produzida a partir de cajaranas coletadas no município de Soure, Ilha do Marajó, Pará, levedura biológica seca (Saccharomyces cerevisae) e sacarose. Na elaboração da bebida, o mosto foi inoculado com o fermento biológico e fermentado a temperatura ambiente (25±2 °C). Durante a fermentação (8 dias) foi determinando o teor de sólidos solúveis. E no produto final obtidos os valores de acidez total (77 mEq L-1), acidez fixa (13,23 mEq L-1), acidez volátil (63,77 mEq L-1), pH (3,24), extrato seco (7,3%), teor alcoólico (10 °GL) e Teor de Sólidos Solúveis (10 °Brix). Os resultados obtidos encontram-se dentro dos padrões estabelecidos pela legislação brasileira, o qual demonstraram a cajarana como uma fonte promissora para a produção de bebida alcoólica fermentada.
Activité et vision professionnelle
Authors: Tomás Jean-Luc , Ianeva Maria , Simonet Pascal , Clot Yves 
Published: September 2020

Notre contribution se propose d’engager une réflexion autour des complémentarités et points de tension entre le concept de « vision professionnelle » et celui d’activité. Si la « vision professionnelle » éclaire le fonctionnement et la dynamique des « façons de voir » dans leur complexité située, elle ouvre à un questionnement autour du développement ou de la fabrique de ce « regard ». En nous appuyant sur des travaux issus de la clinique de l’activité, nous cherchons à montrer comment les modèles de l’activité permettent de reprendre cette question en lien avec le développement psychologique du sujet et des collectifs professionnels.
Combining Three-Dimensional Modeling with Artificial Intelligence to Increase Specificity and Precision in Peptide–MHC Binding Predictions
Authors: Aranha Michelle P. , Jewel Yead S. M. , Beckman Robert A. , Weiner Louis M. , Mitchell Julie C. , Parks Jerry M. , Smith Jeremy C. 
Published: September 2020

Abstract
The reliable prediction of the affinity of candidate peptides for the MHC is important for predicting their potential antigenicity and thus influences medical applications, such as decisions on their inclusion in T cell–based vaccines. In this study, we present a rapid, predictive computational approach that combines a popular, sequence-based artificial neural network method, NetMHCpan 4.0, with three-dimensional structural modeling. We find that the ensembles of bound peptide conformations generated by the programs MODELLER and Rosetta FlexPepDock are less variable in geometry for strong binders than for low-affinity peptides. In tests on 1271 peptide sequences for which the experimental dissociation constants of binding to the well-characterized murine MHC allele H-2Db are known, by applying thresholds for geometric fluctuations the structure-based approach in a standalone manner drastically improves the statistical specificity, reducing the number of false positives. Furthermore, filtering candidates generated with NetMHCpan 4.0 with the structure-based predictor led to an increase in the positive predictive value (PPV) of the peptides correctly predicted to bind very strongly (i.e., Kd &lt; 100 nM) from 40 to 52% (p = 0.027). The combined method also significantly improved the PPV when tested on five human alleles, including some with limited data for training. Overall, an average increase of 10% in the PPV was found over the standalone sequence-based method. The combined method should be useful in the rapid design of effective T cell–based vaccines.
The Effectiveness of a Patakara Device in Improving Oral Function and Quality of Life in People with Intellectual Disabilities
Authors: Tsai Cheng-Hung , Chou Yu-Ching , Lin Jin-Ding , Chen Gunng-Shinng 
Published: September 2020

Background:
Better labial closure strength (LCS) may improve eating, swallowing, and quality of life. Patakara is an efficient device to enhance lip strength. In this study, we analyzed differences in LCS and quality of life between before and after training with Patakara in people with intellectual disabilities.

Methods:
We recruited twenty participants with intellectual disabilities who had poor eating status, lower LCS, or poor oral hygiene status. These participants performed training using Patakara three times a day (3 min each time for five times/week) for 3 months. Oral examination was performed twice, and structural questionnaires and lip force measurements were performed five times. Cheek temperature was also recorded.

Results:
The maximum value of lip force showed a significant increase during the 3-month training period. In addition, the proportion of participants who kept food in the mouth for a long time when eating significantly reduced. Moreover, the physical functioning and mental health scores of SF-36 showed a significant increase.

Conclusions:
Patakara training effectively increased lip muscle strength and improved dietary function. Nevertheless, further studies with a longer training duration to investigate the long-term effects of Patakara training are needed.
Lineability, continuity, and antiderivatives in the non-Archimedean setting
Authors: Khodabandehlou J. , Maghsoudi S. , Seoane-Sepúlveda J. B. 
Published: September 2020

AbstractThis work focuses on the ongoing research of lineability (the search for large linear structures within certain non-linear sets) in non-Archimedean frameworks. Among several other results, we show that there exist large linear structures inside each of the following sets: (i) functions with a fixed closed subset of continuity, (ii) all continuous functions that are not Darboux continuous (or vice versa), (iii) all functions whose Dieudonné integral does not behave as an antiderivative, and (iv) functions with finite range and having antiderivative.
Stock Market Efficiency in the Time of COVID-19: Evidence from Industry Stock Returns
Authors: Lalwani Vaibhav , Meshram Vedprakash Vasantrao 
Published: September 2020

Using industry portfolios as test assets and a battery of statistical tests, we study if the informational efficiency of stock prices has declined after the COVID-19 crisis began. The results suggest that the predictability of stock returns in some industries has increased during the COVID-19 period. Markets appear to have become less informationally efficient during the COVID-19 crisis.
JEL Classification Code: C58, G01, G10, G14.
Global Strategy and Emerging Markets
Authors: Cuervo-Cazurra Alvaro , Ganitsky Joseph , Luo Yadong , Mezias John 
Published: September 2020

We analyze the impact of the home country on the internationalization of firms from emerging markets. We introduce a framework that links the underdevelopment of emerging markets to firm internationalization via firms’ characteristics and strategies. Specifically, we argue that an underdeveloped economy undergoing pro-market transformations and the underdeveloped pro-market institutions, the major characteristics of emerging markets, influence the ownership, capability and innovation of firms and these, in turn, drive their internationalization and success in global competition.
The Elephant That Didn’t Get a Visa to Be in the Room
Authors: Barnard Helena 
Published: September 2020

The issue of visas does not get much attention in international business, perhaps because visas mainly affect people from developing countries: Exemptions exist for most citizens of Triad countries. Yet there are extensive, opaque and country-specific regulations governing the movement of people across borders. In this essay, I speak about my personal experience in trying to obtain a visa, and reflect how visas act as a barrier to full participation in the global economy, both economically and in the cross-border sharing of knowledge. I suggest the possible value of a global oversight body to regulate how visas are granted.
El seguimiento y acompañamiento del docente en formación. “una mirada al trabajo transversal”.
Authors: Gamas Ocaña María Guadalupe 
Published: September 2020

Se presenta un avance de los resultados de la práctica profesional de los docentes en formación, que ha tenido por objetivo brindarles seguimiento y acompañamiento permanente, propiciando la reflexión del quehacer para aproximarse a la autonomía en la toma de decisiones de sus prácticas. Por el momento, sólo se presentan resultados de los indicadores relacionados con el trabajo transversal. La metodología es de enfoque cualitativo empleándose fundamentalmente la técnica de observación en tiempos y situación real del trabajo pedagógico, requiriendo como instrumento una guía de observación.
Palabras clave
Actitudinal. Disciplinar. Interdisciplinar. Metadisciplinar. Transversalidad.
Abstract
It presents an advance of the results of the professional practice of the teachers in training, which has had as objective to provide them follow-up and permanent accompaniment, propitiating the reflection of the work to approach the autonomy in the decision making of their practices. At the moment, only results of indicators related to transversal work are presented. The methodology is of qualitative focus, basically employing the observation technique in times and real situation of the pedagogical work, requiring as an instrument an observation guide.
Keywords
Attitudinal. Discipline. Interdisciplinary. Metadisciplinary. Transversality