bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sentinel lymph node mapping with indocyanine green in cervical cancer patients undergoing open radical hysterectomy: a single-institution series
Authors: Bizzarri Nicolò , Luigi Pedone Anchora , Ferrandina Gabriella , Zannoni Gian Franco , Carbone Maria Vittoria , Fedele Camilla , Teodorico Elena , Gallotta Valerio , Gueli Alletti Salvatore , Chiantera Vito , Fagotti Anna , Scambia Giovanni , Fanfani Francesco 
Published: September 2020

Abstract
Purpose
To assess the rate of bilateral sentinel lymph node (SLN) detection with indocyanine green (ICG), to evaluate the sensitivity and the negative predictive value of cervical cancer patients undergoing open radical hysterectomy; to compare open versus minimally invasive SLN biopsy performance and to assess factors related to no/unilateral SLN mapping.

Methods
We retrospectively reviewed consecutive patients with FIGO 2018 stage IA1 with lymph-vascular space involvement to IIB and IIIC1p cervical carcinoma who underwent SLN mapping with ICG followed by systematic pelvic lymphadenectomy between 05/2017 and 06/2020. Patients were divided according to surgical approach for statistical analysis.

Results
Eighty-five patients met inclusion criteria. Twenty-seven (31.8%) underwent open and 58 (68.2%) underwent minimally invasive SLN mapping. No difference in any SLN mapping (laparotomy 92.6% and minimally invasive 91.4%) or in SLN bilateral detection (laparotomy 72.0% and minimally invasive 84.9%) (p = 0.850 and p = 0.222, respectively), in median number of SLNs mapped and retrieved (2 in both groups, p = 0.165) and in site of SLN mapping per hemi-pelvis (right side, p = 0273 and left side, p = 0.618) was evident between open and minimally invasive approach. Per-patient sensitivity of SLN biopsy in laparotomy was 83.3% (95% CI 35.9–99.6%) and the negative predictive value was 95.0% (95% CI 76.0–99.1%). No difference in per-patient sensitivity was noted between two approaches (p = 0.300). None of the analyzed variables was associated with no/unilateral SLN mapping.

Conclusion
The use of ICG to detect SLN in cervical cancer treated with open surgery allows a bilateral detection, sensitivity and negative predictive value comparable to minimally invasive surgery with potential advantages of ICG compared to other tracers.
Systematic review of modifiable risk factors shows little evidential support for most current practices in Cryptosporidium management in bovine calves
Authors: Brainard Julii , Hooper Lee , McFarlane Savannah , Hammer Charlotte C. , Hunter Paul R. , Tyler Kevin 
Published: September 2020

AbstractCryptosporidiosis is common in young calves, causing diarrhoea, delayed growth, poor condition and excess mortality. No vaccine or cure exists, although symptomatic onset may be delayed with some chemoprophylactics. Other response and management strategies have focused on nutritional status, cleanliness and biosecurity. We undertook a systematic review of observational studies to identify risk or protective factors that could prevent Cryptosporidium parvum infection in calves. Included studies used multivariate analysis within cohort, cross-sectional or case-control designs, of risk factors among young calves, assessing C. parvum specifically. We tabulated data on characteristics and study quality and present narrative synthesis. Fourteen eligible studies were found; three of which were higher quality. The most consistent evidence suggested that risk of C. parvum infection increased when calves had more contact with other calves, were in larger herds or in organic production. Hard flooring reduced risk of infection and calves tended to have more cryptosporidiosis during warm and wet weather. While many other factors were not found to be associated with C. parvum infection, analyses were usually badly underpowered, due to clustering of management factors. Trials are needed to assess effects of manipulating calf contact, herd size, organic methods, hard flooring and temperature. Other factors need to be assessed in larger observational studies with improved disaggregation of potential risk factors.
Generalized disconnection exponents
Authors: Qian Wei 
Published: September 2020

AbstractWe introduce and compute the generalized disconnection exponents$$\eta _\kappa (\beta )$$

η
κ

(
β
)

which depend on $$\kappa \in (0,4]$$

κ
∈
(
0
,
4
]

and another real parameter $$\beta $$
β
, extending the Brownian disconnection exponents (corresponding to $$\kappa =8/3$$

κ
=
8
/
3

) computed by Lawler, Schramm and Werner (Acta Math 187(2):275–308, 2001; Acta Math 189(2):179–201, 2002) [conjectured by Duplantier and Kwon (Phys Rev Lett 61:2514–2517, 1988)]. For $$\kappa \in (8/3,4]$$

κ
∈
(
8
/
3
,
4
]

, the generalized disconnection exponents have a physical interpretation in terms of planar Brownian loop-soups with intensity $$c\in (0,1]$$

c
∈
(
0
,
1
]

, which allows us to obtain the first prediction of the dimension of multiple points on the cluster boundaries of these loop-soups. In particular, according to our prediction, the dimension of double points on the cluster boundaries is strictly positive for $$c\in (0,1)$$

c
∈
(
0
,
1
)

and equal to zero for the critical intensity $$c=1$$

c
=
1

, leading to an interesting open question of whether such points exist for the critical loop-soup. Our definition of the exponents is based on a certain general version of radial restriction measures that we construct and study. As an important tool, we introduce a new family of radial SLEs depending on $$\kappa $$
κ
and two additional parameters $$\mu , \nu $$

μ
,
ν

, that we call radial hypergeometric SLEs. This is a natural but substantial extension of the family of radial $$\hbox {SLE}_\kappa (\rho )s$$

SLE
κ

(
ρ
)

s

.
The value of mammography in women with focal breast complaints in addition to initial targeted ultrasound
Authors: Appelman L. , Appelman P. T. M. , Siebers C. C. N. , Bult P. , Go H. L. S. , Schlooz M. , Mann R. M. 
Published: September 2020

Abstract
Purpose
To determine the added value of mammography in women with focal breast complaints and the utility of initial targeted ultrasound in this setting.

Methods
Women with symptomatic breast disease who were evaluated by breast imaging (mammography/digital breast tomosynthesis and ultrasound) between January 2016 and December 2016 in the Radboud University Medical Centre were included. We retrospectively collected the following data: date of birth, indication of imaging, visibility on mammography/ultrasound, whether biopsy was taken, additional findings, BI-RADS-classification, pathology and follow-up results.

Results
A total of 494 women were included (mean age 46.5, range 30 to 93). In 49 women (9.9%), symptomatic breast cancer was diagnosed, all visible during targeted ultrasound. The negative predictive value of targeted ultrasound was very high (99.8%). Additional findings on mammography were significantly more often malignant when the symptomatic lesion was also malignant (3.8% vs 70%, P < 0.05). In only one patient with symptoms caused by a benign finding, an incidental malignancy was detected on mammography outside the area of complaint (detection rate 2.2/1000 examinations).

Conclusions
The contribution of mammography for cancer detection in women with focal breast complaints is very low when targeted ultrasound is performed. Additional findings are most common in patients with symptomatic breast cancer. Our results suggest that initial targeted ultrasound is a more appropriate initial tool for the evaluation of focal breast complaints. Mammography could be performed on indication only.
miR-194-5p negatively regulates the proliferation and differentiation of rabbit skeletal muscle satellite cells
Authors: Shi Yu , Mao Xudong , Cai Mingcheng , Hu Shenqiang , Lai Xiulan , Chen Shiyi , Jia Xianbo , Wang Jie , Lai Songjia 
Published: September 2020

AbstractSkeletal muscle satellite cells (SMSCs), also known as a multipotential stem cell population, play a crucial role during muscle growth and regeneration. In recent years, numerous miRNAs have been associated with the proliferation and differentiation of SMSCs in a number of mammalian species; however, the regulatory mechanisms of miR-194-5p in rabbit SMSCs still remain scarce. In this study, miR-194-5p was first observed to be highly expressed in the rabbit leg muscle. Furthermore, both the mimics and inhibitor of miR-194-5p were used to explore its role in the proliferation and differentiation of rabbit SMSCs cultured in vitro. Results from both EdU and CCK8 assays showed that miR-194-5p inhibited the proliferation of SMSCs. Meanwhile, Mef2c was identified as a target gene of miR-194-5p based on the dual-luciferase reporter assay results. In addition, upregulation of miR-194-5p decreased the expression levels of Mef2c and MyoG during rabbit SMSCs differentiation on Days 3 and 7 of in vitro culture. Taken together, these data demonstrated that miR-194-5p negatively regulates the proliferation and differentiation of rabbit SMSCs by targeting Mef2c.
Specialization in Hierarchical Learning Systems
Authors: Hihn Heinke , Braun Daniel A. 
Published: September 2020

AbstractJoining multiple decision-makers together is a powerful way to obtain more sophisticated decision-making systems, but requires to address the questions of division of labor and specialization. We investigate in how far information constraints in hierarchies of experts not only provide a principled method for regularization but also to enforce specialization. In particular, we devise an information-theoretically motivated on-line learning rule that allows partitioning of the problem space into multiple sub-problems that can be solved by the individual experts. We demonstrate two different ways to apply our method: (i) partitioning problems based on individual data samples and (ii) based on sets of data samples representing tasks. Approach (i) equips the system with the ability to solve complex decision-making problems by finding an optimal combination of local expert decision-makers. Approach (ii) leads to decision-makers specialized in solving families of tasks, which equips the system with the ability to solve meta-learning problems. We show the broad applicability of our approach on a range of problems including classification, regression, density estimation, and reinforcement learning problems, both in the standard machine learning setup and in a meta-learning setting.
Comparison of Spider Web and Moss Bag Biomonitoring to Detect Sources of Airborne Trace Elements
Authors: van Laaten Neele , Merten Dirk , von Tümpling Wolf , Schäfer Thorsten , Pirrung Michael 
Published: September 2020

AbstractAtmospheric particulate matter has become a major issue in urban areas from both a health and an environmental perspective. In this context, biomonitoring methods are a potential complement to classical monitoring methods like impactor samplers, being spatially limited due to higher costs. Monitoring using spider webs is compared with the more common moss bag technique in this study, focusing on mass fractions and ratios of elements and the applicability for source identification. Spider webs and moss bags with Hypnum cupressiforme were sampled at the same 15 locations with different types of traffic in the city of Jena, Germany. In the samples, mass fractions of 35 elements, mainly trace metals, were determined using inductively coupled plasma-optical emission spectroscopy (ICP-OES) and inductively coupled plasma-mass spectrometry (ICP-MS) after aqua regia digestion. Significantly higher mass fractions in spider webs than in moss bags were found, even after a much shorter exposure period, and could not be ascribed completely to a diluting effect by the biological material in the samples. Different mechanisms of particle retention by the two materials are therefore assumed. More significant correlations between elements have been found for the spider web dataset. Those patterns allow for an identification of different sources of particulate matter (e.g. geogenic dust, brake wear), while correlations between elements in the moss bags show a rather general anthropogenic influence. Therefore, it is recommended to use spider webs for the short-term detection of local sources while moss bag biomonitoring is a good tool to show a broader, long-term anthropogenic influence.
Porous asphalt concrete: A review of design, construction, performance and maintenance
Authors: Chen Jian-Shiuh , Yang Chin Hung 
Published: September 2020

AbstractPorous asphalt concrete (PAC) is an open-graded friction course that is specifically designed to have high air void contents for removing water from the pavement surface. PAC surfaces, which include open-graded friction courses, permeable friction courses, and drainage asphalt pavements, have increasingly gained acceptance among agencies and industry in the world. PAC might be susceptible to freeze-thaw damage in cold climates and require winter maintenance practices. The life span of PAC pavements shows a large variation depending on climates, traffic volumes and loadings, design and construction practices. The objective of this paper was to review design, construction, and performance that could maximize the advantages and minimize the disadvantages associated with the use of PAC mixtures. A consolidated review of the worldwide literature on PAC applications was conducted, with attention to the use of PAC in agency practices, and specifications for PAC from the world were evaluated. Based on an analysis of the results of this review, two key features were emphasized: (1) a recommended practice for material selection and design of PAC, and (2) a recommended practice for PAC construction and maintenance. Key points include a careful assessment of the PAC drainage and an adequate asphalt content to improve the performance of the pavement surface. A proper binder content stabilized by additives such as fibers and polymers is essential to ensure sufficient film thickness that is critical to the durability of the PAC mix in the long run.
Why the Social Connection Model Fails: Participation is Neither Necessary nor Sufficient for Political Responsibility
Authors: Gunnemyr Mattias 
Published: September 2020

AbstractIris Marion Young presents a social connection model on which those, and only those, who participate in structural processes that produce injustice have a forward-looking responsibility to redress the resulting injustice by challenging the structures that produce it (she sometimes calls this a political responsibility [Young 2011]). In Young's view, this is an all-things-considered, albeit discretionary, responsibility. I argue that participation in a structural process that produces injustice is neither necessary nor sufficient for having political responsibilities, and that therefore the social connection model must be rejected. A subtler model is needed, one that depicts participation in a structural process that produces injustice as sufficient (but not necessary) for having pro tanto forward-looking responsibilities to redress the process, unless the participating agent satisfies certain excusing conditions. I suggest the intuitive force of the thought that mere participation gives us political responsibilities can be explained by more fundamental considerations. Hastily, we might conclude that all participants have political responsibilities simply because most of them satisfy at least one of the following conditions: they cause injustice to continue, they are morally responsible for injustice, they benefit from injustice, they have communal ties with the victims of injustice, or they have the capacity to redress injustice.
Impact of preoperative chlorhexidine gluconate (CHG) application methods on preoperative CHG skin concentration
Authors: Warren Bobby G. , Nelson Alicia , Warren David K. , Baker Meghan A. , Miller Candace , Habrock Tracey , Bongu Jahnavi , Gowda Abinav , Johnson Jacob , Anderson Deverick J. ,   CDC Prevention Epicenters Program
Published: September 2020

AbstractElective surgical patients routinely bathe with chlorhexidine gluconate (CHG) at home days prior to their procedures. However, the impact of home CHG bathing on surgical site CHG concentration is unclear. We examined 3 different methods of applying CHG and hypothesized that different application methods would impact resulting CHG skin concentration.
Dietary intake, anthropometric measurements, biochemistry profile and their associations with chronic kidney disease and diabetes mellitus
Authors: Ferreira Emily de S. , da Silva Luciana S. , da Costa Glauce D. , Moreira Tiago R. , Borges Luíza D. , Cotta Rosângela M. M. 
Published: September 2020

AbstractThe chronic kidney disease (CKD) and diabetes mellitus (DM) are considered a serious public health problem. The objective was investigating the association of DM with the anthropometric measures, biochemical profile and dietary intake in patients with CKD. Is a cross-sectional study done in 2017, with 51 patients previously diagnosed with CKD. We collect socio-demographic, lifestyle variables, anthropometric measurements, biochemical profile and dietary intake. We using the Kolmogorov–Smirnov test, followed by Pearson'sχ2test and Student'sttest. Data were analysed using several multivariable logistic regression models, including the socio-demographic, anthropometric, dietary intake and biochemical variable. Variables withP≤ 0⋅20 in the univariate analyses were selected and kept in the block in the simple and multiple logistic regression analysis, to determine the differences between the categories and the factors associated with the presence of DM or not, remaining in the model final, only the significant variables (P≤ 0⋅05). Each variable was adjusted for all other variables included in the univariate analysis. The strength of the association was assessed by the odds ratio and 95% confidence intervals (CI). The multivariate logistic regression analysis evidenced that the increase of 1 cm in waist circumference and 1 mg/dl in VLDL-c values increases the chance of DM, respectively, by 8⋅4% (OR 1⋅076;P0⋅05) and 8⋅8% (OR 1⋅102;P0⋅01). In contrast, an increase of 1 mg/dl in total cholesterol decreases the chance of developing DM by 3⋅1% (OR 0⋅965;P0⋅01), that is, it becomes a protective factor. The present study identified the associations between overweight, dietary intake and biochemical tests.
Proteomic investigation of Peristenus spretus ovary and characterization of an ovary-enriched heat shock protein
Authors: Tian Miaomiao , Xia Yayun , Cai Ducheng , Mao Jianjun , Luo Shuping 
Published: September 2020

AbstractPeristenus spretus (Hymenoptera: Braconidae) is one of the most important endoparasitoids used for biological control of the green mirid bug, Apolygus lucorum Meyer-Dür (Heteroptera: Miridae). However, what we know about its reproductive genetics is very limited. Here, the composition of ovarian proteins in P. spretus was analyzed. Mass spectrum data searched against the non-redundant NCBI protein and UniProt protein database identified 1382 proteins and revealed an enrichment of the heat shock protein 83 (HSP83) in P. spretus ovary. The Pshsp83 complete cDNA is 2175 bp in length and encodes a protein of 724 amino acids with a calculated molecular mass of 83.4 kDa and a theoretical isoelectric point of 4.87. Transcription of Pshsp83 appeared from days 1 to 13 post-emergence and peaked at 13th day. Immuno-localization showed that the HSP83 protein was present in cytoplasm of germarium and in egg chambers of the whole ovariole. The transcript abundance of Pshsp83 fluctuated drastically after heat shocks at different temperatures and the maximum emerged at 35°C. The exposure to 35°C caused no dramatic effects on reproductive parameters of adult females such as pupation rate, cocoon weight, emergence rate, sex ratio and developmental duration, but did on longevity. These results suggested that the HSP83 protein is involved in life-span regulation in the P. spretus.
Nilpotent n-tuples in SU(2)
Authors: Antolín-Camarena Omar , Villarreal Bernardo 
Published: September 2020

AbstractWe describe the connected components of the space $\text {Hom}(\Gamma ,SU(2))$ of homomorphisms for a discrete nilpotent group $\Gamma$. The connected components arising from homomorphisms with non-abelian image turn out to be homeomorphic to $\mathbb {RP}^{3}$. We give explicit calculations when $\Gamma$ is a finitely generated free nilpotent group. In the second part of the paper, we study the filtration $B_{\text {com}} SU(2)=B(2,SU(2))\subset \cdots \subset B(q,SU(2))\subset \cdots$ of the classifying space $BSU(2)$ (introduced by Adem, Cohen and Torres-Giese), showing that for every $q\geq 2$, the inclusions induce a homology isomorphism with coefficients over a ring in which 2 is invertible. Most of the computations are done for $SO(3)$ and $U(2)$ as well.
Intervention Fidelity of a Volunteer-Led Montessori-Based Intervention in a Canadian Long-Term Care Home
Authors: Hunter Paulette V. , Rissling Amanda , Pickard Leticia , Thorpe Lilian , Hadjistavropoulos Thomas 
Published: September 2020

ABSTRACTMontessori-based interventions (MBIs) were developed to promote guided participation in meaningful activities by people with dementia patients. In this study, we assessed nursing home volunteers’ fidelity to an MBI, relying primarily on a qualitative descriptive design. We completed a deductive content analysis of eight volunteer interviews using the Conceptual Framework for Intervention Fidelity. We also calculated average volunteer and resident scores on the Visiting Quality Questionnaire (VQQ), which assesses volunteers’ and residents’ perceptions of visits. We found good evidence that volunteers attended scheduled visits, made use of pre-designed activities, and attended to training recommendations. Most reported enjoying the visits (VQQ $ \overline{x} $ = 6.12, standard deviation [SD] = 0.75) and receiving a positive response from residents (VQQ $ \overline{x} $ = 5.46, SD = 0.88). Nevertheless, use of pre-designed activities and response to the MBI was lower for volunteers working with residents who had late-stage dementia. Therefore, overall, fidelity depended on the cognitive status of the resident.
A rare indication of permanent pacemaker implantation in children: congenital long QT syndrome
Authors: Taşar Mehmet , Yaman Nur Dikmen , Dursin Huseyin , Şimşek Murat , Özgür Senem 
Published: September 2020

AbstractCongenital Long QT Syndrome (LQTS) is a dangerous arrhythmic disorder that can be diagnosed in children with bradycardia. It is characterised by a prolonged QT interval and torsades de pointes that may cause sudden death. Long QT syndrome is an ion channelopathy with complex molecular and physiological infrastructure. Unlike the acquired type, congenital LQTS has a genetic inheritance and it may be diagnosed by syncope, stress in activity, cardiac dysfunction, sudden death or sometimes incidentally. Permanent pacemaker implantation is required for LQTS with resistant bradycardia even in children to resolve symptoms and avoid sudden death.