bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Diabetes Care in Patients with Schizophrenia: A Case-Control Study.
Authors: karim mustafa Abdul , Al-Baz Nadeen Wael , Ouanes Sami , Khalil Ali , Assar Ahmed , Alsiddiqi Abdulkarim , Dabous Zeinab , Zirie Mahmoud , Woodruff Peter , Malik Rayaz , Haddad Peter Michael 
Published: June 2020

Abstract
BackgroundPatients with schizophrenia are at least twice as likely to develop diabetes mellitus compared to the general population. This is of significance in Qatar given the high prevalence of obesity and diabetes. Furthermore, the lifespan of people with schizophrenia and diabetes is shortened by approximately15 years due to long-term microvascular and macrovascular complications. High quality diabetes care can significantly reduce morbidity and mortality. We assessed the level of diabetes care delivered to patients with schizophrenia and diabetes compared to those with diabetes alone.MethodsWe performed a retrospective chart review of patients with diabetes mellitus with (n=73) and without (n=73) schizophrenia. Demographic information and electronic medical records were reviewed for 6-month and 1-year American Diabetic Association standards of diabetes care. Optimal diabetes care was defined as having completed glycated hemoglobin (HbA1c), lipid profile and retinal examination within 12 months. ResultsOptimal diabetes care was significantly lower in patients with schizophrenia and diabetes compared to diabetes alone [26.0% (n=19/73) vs 52.1% (n=38/73), p=0.002]. Patients with diabetes and schizophrenia were also significantly less likely to have had body mass index recorded within six months (p=0.008) and HbA1c (p=0.006), lipid profile (p=0.015), estimated glomerular filtration rate (eGFR) (p=0.001) and order for retinal screening (p=0.004) over 12 months. After adjusting for multiple comparisons, only assessment of eGFR (p=0.01) and order for retinal screening (p=0.04) remained significant. ConclusionPatients with schizophrenia and diabetes in Qatar receive sub-optimal diabetes care compared to those with diabetes alone.
Relationship between serum microRNA-223 and microRNA-126 and plaque stability in patients with carotid atherosclerosis
Authors: zhang Ying , li Jian , li Jie , ma Lin , zhang Shuhua 
Published: June 2020

Abstract
Background

Numerous researches have demonstrated the essential functions of microRNAs (miRNAs) in cardiovascular disease. Herein, we want to probe into the roles of miR-126 and miR-223 in the prediction of plaque stability of carotid atherosclerosis (CA).
Methods

First, miRNA microarray was performed to analyze the differentially expressed miRNA in serum of normal controls and CA patients. Next, the differential expression of miR-223 and miR-126 in CA was verified and the correlations of their expression levels with plaque stability-related factors were analyzed. Then, the predictive efficacy of miR-223 and miR-126 on plaque stability was analyzed by receiver operating characteristic curve, then the targeting relationships of miR-223 and miR-126 with COX2 were verified by online prediction and luciferase activity assay. Finally, the relationship between COX2 expression and CA plaque stability was analyzed.
Results

Expression levels of miR-223 and miR-126 were decreased in the serum of CA patients and they had good diagnostic efficacy for CA. Additionally, we found that the expression levels of miR-223 and miR-126 in the serum of CA patients with unstable plaque were lower than those with stable plaque. miR-223 and miR-126 were negatively correlated with plaque instability-related indicators, while COX2, a direct target gene of miR-223 and miR-126, was positively related to plaque instability-related indicators.
Conclusion

This study indicates that miR-223 and miR-126 are lowly expressed in serum of CA patients, which can be used as a clinical indicator for predicting the plaque stability in CA patients.
SLC40A1 mediates ferroptosis and cognitive dysfunction in type 1 diabetes
Authors: Hao Lijun , Mi Jun , Song Liping , Guo Yinnan , Li Yanli , Yin Yiru , Zhang Ce 
Published: June 2020

Abstract
Objective : Cognitive dysfunction often accompanies diabetes. Both hypoglycemia and hyperglycemia cause cognitive dysfunctions. However, the underlying pathophysiology remains unclear. Recent evidence show that ferroptosis primarily triggers nerve cell death, Alzheimer's disease (AD), Huntington’s disease (HD), and Parkinson's disease (PD). We purposed to investigate whether ferroptosis is a vital pathogenic pathway in diabetes-induced cognitive dysfunction.
Methods and results : Type 1 diabetic rat model was created by intraperitoneal injection of streptozotocin (STZ). Significant cognitive dysfunction was observed in the diabetic rats as evidenced by increase in latency period to find a hidden platform and decreased cumulative time spent in the target quadrant in the Morris water maze test. We detected the amplitude of low-frequency fluctuation (ALFF) of the BOLD (Blood Oxygenation Level-Dependent) signal using resting-state functional magnetic resonance imaging (rs-fMRI). Consequently, we found that the ALFF values, as well as the T2 relaxation time of the bilateral hippocampus, were reduced in Type 1 diabetic rats. We detected Fe 2+ level and lipid peroxidation products (MDA and 4-HNE) in the hippocampus. Mitochondria and neuron injury in the STZ-induced diabetic rats were determined using a Transmission Electron Microscope and Nissl body staining. Iron overload and ferroptosis were detected in the hippocampus. Furthermore, mRNA microarray analysis revealed 201 dysregulated mRNAs in STZ-induced type 1 diabetes (T1D). Pathway enrichment analyses indicated that differentially expressed mRNAs associated-coding genes were associated with ferroptosis. Among ferroptosis signaling pathway genes, Slc40a1 gene (ferroportin) was downregulated.
Conclusion : We show that ferroptosis is associated with diabetic cognitive dysfunction and Slc40a1 mediates ferroptosis in Type 1 diabetes.
Comparative Proteomic Analysis Reveals That the Heterosis of Two Maize Hybrids is Related to Enhancement of Stress Response and Photosynthesis Respectively
Authors: Wang Daoping , Mu Yongying , Hu Xiaojiao , Ma Bo , Wang Zhibo , Zhu Li , Xu Jiang , Huang Changling , pan yinghong 
Published: June 2020

Abstract
BackgroundMaize is a major crop worldwide and heterotic hybrids play important roles in global maize production. Heterosis refers hybrid progeny of species or varieties exhibiting superior traits compared with those of their parents and much attention has been paid to heterosis associated genes recently. The hybridization between parents can change the expression pattern of some proteins such as non-additive proteins which might lead to heterosis, so that comparative proteomic analysis of maize hybrid and its parents is helpful for understanding the mechanism of heterosis.ResultsSecond seedling leaves of maize hybrids "Zhongdan 808" and "Zhongdan 909" and their parents were collected at three-leaf stage for protein extractions. Over 2,000 protein groups were accurately assessed in the two hybrids and their parents by label-free quantification. Quantitative data analyses of the proteomes revealed that the two hybrids were more similar to their female parents. Additionally, pathway enrichment analysis showed that most non-additive proteins in Zhongdan 808 were mainly enriched in stress-related pathways, while those in Zhongdan 909 were mainly enriched in photosynthesis. ConclusionsIn comparison with their parents, the excellent agronomic traits of hybrid Zhongdan 808 was correlated with the high expression levels of some proteins related to stress responses and and metabolic functions, while those of Zhongdan 909 was correlated with photosynthesis. Our proteomics results supported previous physiological and morphological research. This work may provide useful information for understanding of the molecular mechanisms involved in the heterosis of hybrid maize.
Perceived Barriers to Weight Management: A Qualitative Study on Overweight and Obese Women in Shiraz, Iran
Authors: borazjani mohadese , amini maryam , Faghih Shiva 
Published: June 2020

Abstract
Background: Obesity is among the most important health challenge, with an increasing incidence in current century. It is considered as an important factor lead to social unacceptability. Almost in all societies women are more careful and sensitive about their beauty and appearance than men. The purpose of this study was to assess perceived barriers to weight- loss programs among women with obesity in Shiraz.Method: This qualitative study was conducted using eight semi-structured focus group discussions (FGDs) among 48 women and seven in-depth interviews with key informants. All eligible participants for FGDs were selected through a public call in Shiraz. Results: Dietary, socio-cultural, supportive- psychological and economic issues were identified as the main barriers to weight-loss programs.Conclusion: Data collected from the individual and group interviews provided extensive information on the strengths and weaknesses of dietary programs. The results of this study can be used to improve the services for obese and overweight people as well as expanding the knowledge of dietitians for developing more efficient weight-loss programs.
Dental Implant Maintenance Experience: Testing Knowledge and Clinical Practices of Libyan Implant Clinicians
Authors: Huni Rabie M El , Kareimi Yaser El 
Published: June 2020

Abstract
Background: This study was aimed to survey implant clinicians in Libya in order to assess their routine approach for dental implant maintenance and to determine if a relationship exists between the formal undergraduate education and their previous attendance and interest in future implant related continuing education courses.Methods: After an extensive review of the literature, a 35–question paper survey, specifically developed for this study, was distributed to all implant clinicians attending a national continuing education course that was held in Tripoli on June/29/2018. All items on the survey reflected content found in publications that addressed maintenance of dental implants.Participants voluntarily completed and submitted their questions survey to the corresponding author before the end of the course day.Results: Targeting 60 participants, the response rate was 63.33% (n=38).Four (10.5%) reported that they have practiced for over 15 years, while Nine (23.6%) have practiced 11 to 15 years. Fourteen (36.8%) have practiced 5 to 10 years and Eleven (28.9%) have practiced 5 years or less. Fourteen (36.8%) reported that they have not received training in class room and clinic on implant care while attending dental school. 5 (13.1%) have not participated in any continuing education course on implant maintenance after school graduation. The majority (94.7%) of the implant clinicians expressed interest in continuing education courses to strengthen backgrounds in maintenance of dental implants.Conclusions: Results indicated that additional knowledge need to be gained regarding dental implant care in order to guide patients’ confidence toward the optimal most successful teeth replacement option. Furthermore, a well-established structured academic program might be necessary to teach implant maintenance at undergraduate and postgraduate levels both theoretically and practically.
Total Cardiovascular Risk in the Elderly Population of Spain: The Epicardian Risk Score
Authors: Gabriel Rafael , Muñiz Javier , Vega Saturio , Moral Irene , Lopez Isidro , Castro Teresa R. Pérez , Rodriguez-Salvanés Francisco , Suárez Carmen , Novella Blanca , Brotons Carlos 
Published: June 2020

Abstract
Background: Cardiovascular risk estimation in people over 70 years is problematic. Most scores have been derived from cohorts of middle-aged people, with older persons under-represented. The predictive power of classical cardiovascular risk factors reduce with age. The aim is to develop a specific score for the elderly populationMethods: Population-based cohort established in 1995. Setting: Three geographical areas of Spain (Madrid, Ávila and Lugo). Participants: 3,729 people older than 64 years, free of any cardiovascular diseases (CVD), at baseline. Measurements: Suspected fatal and nonfatal CVD (both coronary heart disease and stroke) were yearly investigated and confirmed using the WHO-MONICA criteria. All participants were followed until the occurrence of the first CVD event, until death or until December 31th 2015 if alive.Results: Age was the strongest predictor of 10-year CVD both in men and women. In men, variables associated to CVD were high blood pressure treatment (HR: 1,35; 95% CI: 1,067 , 1,710), diabetes (HR: 1,359; 95% CI: 0,997 , 1,852) and smoking (HR:1,207; 95%CI: 0,945 , 1,541), and in women smoking (HR: 1,881 95%CI: 1,356 , 2,609) and diabetes (HR:1,285; 95%CI:0,967 , 1,707). Total-cholesterol did not increased the risk of CVD either in males or females. However, total-cholesterol level (>200mg/dl) were negatively associated both in men and women.Conclusions: In old Spanish men, 10-year total CVD is significantly increased by age, diabetes and antihypertensive treatment, and in old women by diabetes and smoking. Total-cholesterol levels did not increased the risk of CVD either in males or females.
Fluorescent bead-based serological detection of Toxoplasma gondii infection in chickens
Authors: Fabian Benedikt T. , Hedar Fatima , Koethe Martin , Bangoura Berit , Maksimov Pavlo , Conraths Franz J. , Villena Isabelle , Aubert Dominique , Seeber Frank , Schares Gereon 
Published: June 2020

Abstract
Background: Free-ranging chickens are often infected with Toxoplasma gondii. Their infection indicates environmental contamination with T. gondii. The detection of infected birds relies primarily on serological assays. Methods: Here, we established a bead-based multiplex assay (BBMA) using the Luminex technology for the specific and sensitive detection of T. gondii infections in chickens. Recombinant biotinylated T. gondii surface antigen 1 (TgSAG1bio) bound to streptavidin-conjugated magnetic Luminex beads served as antigen. Serum antibodies were detected by a fluorophore-coupled secondary antibody. Beads of differing color codes were conjugated with anti-chicken IgY or chicken serum albumin and served for each sample as an internal positive or negative control, respectively. The assay was validated with sera from experimentally and naturally infected chickens. The results were compared to those from reference methods, including other serological tests and bioassay in mice.Results: In experimentally infected chickens, the vast majority (98.5%, n=65/66) of inoculated birds tested seropositive in the BBMA. This included all chickens positive by magnetic-capture PCR (100%, n=45/45). Most, but not all inoculated and TgSAG1bio-BBMA-positive chickens were also positive in two previously established TgSAG1-ELISAs (TgSAG1-ELISASL, n=61/65; or TgSAG1-ELISASH, n=60/65), or positive in an immunofluorescence assay (IFAT, n=64/65)) and in a modified agglutination test (MAT, n=61/65). All non-inoculated control animals (n=28/28, 100%) tested negative. In naturally exposed chickens, the TgSAG1bio-BBMA showed a high sensitivity (98.5%; 95% Confidence Interval: 90.7-99.9%) and specificity (100%; 85.0-100%) relative to a reference standard established using ELISA, IFAT and MAT. Almost all naturally exposed chickens that were positive in bioassay or by PCR tested positive in the TgSAG1bio-BBMA (93.5%; 77.1-98.9%), while all bioassay- or PCR-negative chickens remained negative (100%; 85.0-100%).Conclusions: The TgSAG1bio-BBMA represents a suitable method for the detection of T. gondii infections in chickens with high sensitivity and specificity, which is comparable or even superior to other tests. Since assays based on this methodology allow for the simultaneous analysis of a single biological sample with respect to multiple analytes, the described assay may represent one component in future multiplex assays for broad serological monitoring of poultry and other farm animals, including pigs or small ruminants, for various pathogens.
Gender Disparities in Cardiovascular Health Metrics among Rural-Dwelling Older Adults in China: a population-based study
Authors: Han Xiaolei , Jiang Ziying , Li Yuanjing , Wang Yongxiang , Liang Yajun , Dong Yi , Tang Shi , Du Yifeng , Qiu Chengxuan 
Published: June 2020

Abstract
Background: Cardiovascular health (CVH) metrics among Chinese older adults are poorly understood. We investigated gender disparities in CVH metrics and their management among rural-dwelling older adults in China.Methods: This community-based study included 5026 participants (age ≥65 years; 57.2% women) in the baseline survey of a multimodal intervention study in rural China. Data were collected through face-to-face interviews, clinical examinations, and laboratory tests in March-September 2018. We defined six CVH metrics (three behavioral factors—smoking, body mass index, and physical activity; three biological factors—blood pressure, total cholesterol, and blood glucose) following the modified American Heart Association’s recommendations. We performed descriptive analysis separately for men and women.Results: Of all participants, only 0.8% achieved ideal levels in all six CVH metrics. Men were more likely than women to have ideal levels in all CVH metrics but smoking. Women had higher prevalence of ideal global CVH metrics (9.7% in women vs. 7.8% in men) and behavioral CVH metrics (18.3% vs. 9.5%) (p<0.001), whereas men had higher prevalence of ideal biological CVH metrics (5.4% in men vs. 3.5% in women, p<0.001). The prevalence of ideal global and behavioral CVH metrics increased with age in both women and men (p for trend<0.001). Women were more likely to be aware of their hypertension and diabetes, and to receive antihypertensive treatment, while men were more likely to achieve the goal of high cholesterol treatment (p<0.05).Conclusions: The CVH metrics among older adults living in the rural communities in China are characterized by an extremely low proportion of optimal global CVH metrics and distinct gender differences, alongside poor management of major biological risk factors.Trial registration: ChiCTR1800017758.
Frailty Indexed Classification of Bangladeshi Older Adults' Physio-psychosocial Health and Associated Risk Factors: A Cross-sectional Survey Study
Authors: Rahman Mohammad Meshbahur , Hamiduzzaman Mohammad , Akter Saleha , Farhana Zaki , Hossain Mohammad Kamal , Hasan Nayeem , Islam Md. Nazrul 
Published: June 2020

Abstract
Background: Frailty is associated with healthy ageing, and it has been identified as a means of measuring older adults’ physio-psychosocial health. This is true that we know about the ageing trends and common diseases of older adults living in low- and lower-middle-income countries, but literature to date does not widely feature their health status based on frailty. This study aims to understand the prevalence of frailty in Bangladeshi older adults; classify their health status; and investigate associated risk factors.Methods: A cross-sectional study was conducted in north-eastern region [i.e. Sylhet City Corporation] of Bangladesh. Four hundred participants aged 55 years and over were randomly selected who are ageing-in-place in the community. These participants attended in a person-centered health assessment session and completed a multi-indicator survey questionnaire. We used a 30-indicators Frailty Index to categorize their health status into: good health [no-frail]; slightly poor health [least frail]; poor health [moderately frail]; and very poor health [frailest]. A chi-square test and binary logistic regression analysis were conducted.Results: The participants’ mean age was 63.6 years, and 74% of them were assessed in poor to very poor health [(moderately frail/65% - frailest/9%). The age, marital status, occupation and religion of the participants were significantly associated with frailty. The oldest aged, female, illiterate and Muslim participants were found frailer than their counterparts. Participants aged 70 years and above were 3.18 times more likely to experience frailty [medical conditions] than the pre-elderly age group (55-59 years) and female participants were 1.8 times more vulnerable to medical conditions than male. Also, the older adults living alone and staying at home without regular job were at higher risk of frailty [poor health] than others.Conclusions: Our study results confirm the prevalence of frailty-related disorders in Bangladeshi older adults and highlight the importance of targeted clinical and community-led preventive care programs.
Mild behavioral impairment is related to frailty in cognitively normal older adults: a cross-sectional study
Authors: Fan Shaoyi , Liang Ximin , Yun Tianchan , Pei Zhong , Hu Bin , Ismail Zahinoor , Yang Zhimin , Xu Fuping 
Published: June 2020

Abstract
Background: Frailty and cognitive decline are highly prevalent among older adults. However, the relationship between frailty and mild behavioral impairment (MBI), a neurobehavioral syndrome characterized by later-life emergence of sustained neuropsychiatric symptoms, has yet to be elucidated.We aimed to evaluate the associations between mild behavioral impairment and frailty in cognitively normal older adults.Methods: This is a cross-sectional study. A consecutive series of 137 cognitively normal older adults in the Anti-Aging study, recruited from primary care clinics, were enrolled. Frailty was estimated using the original Fried phenotype. MBI was evaluated by the Mild Behavioral Impairment Checklist at a cut-off point of >8 (optimizing sensitivity and specificity), which was developed to assess emergent neuropsychiatric symptoms in accordance with the MBI criteria. Cognition was assessed with the Chinese versions of the Montreal Cognitive Assessment (MoCA-BC) and Mini-mental State Examination (MMSE). Multivariate logistic regression was performed to estimate the relationship between MBI and objective cognition with frailty status.Results: At baseline, 30.6% of the older adults had frailty, 35.0% had prefrailty and 18.2% had MBI (MBI+ status). Multivariate logistic regression analysis demonstrated that compared to MBI- status (without MBI), MBI+ was more likely to have frailty (odds ratio [OR] = 7.44, p = 0.02). The frailty and MBI categories were both significantly associated with both MMSE and MoCA-BC score (p<0.05).Conclusions: Both frailty and MBI status are related to higher risk of cognitive impairment. MBI is significantly associated with an increased risk of having frailty before overt cognitive impairment. This association merits further study to identify strategies to the early detection, prevention and therapeutic intervention of frailty.
Functional selection associated with microbial genome size under polycyclic aromatic hydrocarbons (PAHs) pollution stress in soils
Authors: Dong Yuzhu , Wu Shanghua , Fan Haonan , Li Xianglong , Li Yijing , Xu Shengjun , Bai Zhihui , Zhuang Xuliang 
Published: June 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.