bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Social Connections Mitigate Hold-up and Facilitate Cooperation? Evidence from Supply Chain Relationships
Authors: Dasgupta Sudipto , Zhang Kuo , Zhu Chenqi 
Published: August 2020

AbstractWe show that prior social connections can mitigate hold-up in bilateral relationships and encourage relation-specific investment and cooperation when contracts are incomplete. We examine vertical relationships and show that relation-specific innovative activities by suppliers increase with the existence and strength of prior social connections between the suppliers’ managers and board members and those of their customers. To establish causality, we exploit connection breaches due to manager/director retirements or deaths and find that innovation drops for affected suppliers after the departure of socially connected individuals relative to unaffected suppliers. Our work sheds light on how social connections can shape firm boundaries.
The pitfalls of power sharing in a new democracy: the case of the National Party in South Africa
Authors: Southern Neil 
Published: August 2020

AbstractA key political feature of South Africa's transformation was the African National Congress, the National Party and Inkatha Freedom Party working together in a grand coalition. This arrangement was praised by leading power-sharing theorist Arend Lijphart. The unity government began in 1994 but two years later the National Party withdrew. This article explores power sharing during the initial phase of the settlement and discusses three aspects of it. First, the South African example points to the electoral drawbacks of power sharing for minor parties. Second, the National Party's participation in the coalition stifled the early development of substantial political opposition which slowed the pace of democratic consolidation. Third, participation in a power-sharing arrangement undermined the National Party's electoral fortunes contributing to its dissolution in 2005. This was an unexpected outcome for a party which had co-authored the country's settlement a little over a decade earlier.
A green transition in South Africa? Sociotechnical experimentation in the Atlantis Special Economic Zone
Authors: Grant Richard , Carmody Pádraig , Murphy James T. 
Published: August 2020

AbstractSouth Africa faces interconnected challenges of developing and diversifying its economy and adapting to and mitigating the impacts of climate change. A green policy tilt is ascendant in the country, manifest in a cascading array of policies and special initiatives. Utilising concepts from the multi-level perspective on socio-technical transitions, we assess Africa's first designated Green Special Economic Zone (SEZ), Atlantis SEZ (ASEZ) in the Western Cape, a niche innovation aimed at transforming the Province's industrial base. This initiative is very ambitious in four respects: (1) it links green SEZ development in a deprived metropolitan area to the broader regional economy; (2) it utilises an innovative governance structure; (3) it promises localization economies and export potential; and (4) it connects SEZ niche experimentation with emergent renewable energy regimes. While elements are in place which might seed a sociotechnical transition, societal and political forces (i.e. landscape features) continue to limit its realisation, highlighting the immanent, structural realities shaping South Africa's economic futures.
Role of diagnostic intracytoplasmic sperm injection (ICSI) in the management of genetically determined zona pellucida-free oocytes during in vitro fertilization: a case report
Authors: Metwalley Ahmad , Brasha Nabeel , Esteves Sandro C. , Fawzy Mohamed , Brasha Hadiya , Hellani Ali , El Hamshary Manal , Khamiss Omaima 
Published: August 2020

AbstractPurpose:To report the utilization of diagnostic intracytoplasmic sperm injection (D-ICSI), an ICSI cycle performed in the natural cycle, to obtain information about embryo development potential after sperm injection into zona pellucida (ZP)-free oocytes.Materials and Methods:We report the case of a couple with primary unexplained infertility with a history of previous failed, in vitro fertilization intracytoplasmic sperm injection (IVF-ICSI) cycles characterized by the presence of ZP-free oocytes. Whole exome sequencing (WES) was carried out to analyse the possible genetic basis of oocyte abnormality.Results:Diagnostic ICSI provided information about the embryo development potential from ZP-free oocytes and allowed better planning of the subsequent ICSI cycle. WES revealed that the absence of ZP was likely to be due to a new (ZP1) mutation. The subsequent ICSI cycle resulted in the delivery of a healthy baby.Discussion:To the best of our knowledge, our report is the first to describe the use of D-ICSI to determine the feasibility of embryo development and implantation in a patient with ZP1 mutation, resulting in the subsequent delivery of a healthy baby. We used ‘diagnostic’ ICSI in the normal menstrual cycle to explore the feasibility of embryo development after sperm injection into ZP-free oocytes. Our results may expand the spectrum of diagnostic procedures associated with unexplained infertility.
COVID-19 and the role of information processing
Authors: van der Leeuw Sander 
Published: August 2020

Abstract
The various crises that have emerged since 2000 are driven by an increasing maladaptation of our societies’ information processing capabilities to the dynamics in which our societies find themselves. These capabilities have been built up path dependently over centuries, and to understand them we need to look closely at their history. Changes in technology, demography and resource use and environmental change are all part of a co-evolution in which societies’ information processing capacities play a central role. The information and communications technology revolution has accelerated developments in all of these domains and has weakened some fundamental institutions. This paper discusses how these processes might affect the long-term future of our societies.
Analysis of Compound Climate Extremes and Exposed Population in Africa Under Two Different Emission Scenarios
Authors: Weber T. , Bowyer P. , Rechid D. , Pfeifer S. , Raffaele F. , Remedio A. R. , Teichmann C. , Jacob D. 
Published: August 2020

AbstractIt is well established that Africa is particularly exposed to climate extremes including heat waves, droughts, and intense rainfall events. How exposed Africa is to the co‐occurrence of these events is however virtually unknown. This study provides the first analysis of projected changes in the co‐occurrence of five such compound climate extremes in Africa, under a low (RCP2.6) and high (RCP8.5) emissions scenario. These changes are combined with population projections for a low (SSP1) and high (SSP3) population growth scenario, in order to provide estimates of the number of people that may be exposed to such events at the end of the 21st century. We make use of an ensemble of regional climate projections from the Coordinated Output for Regional Evaluations (CORE) project embedded in the Coordinated Regional Climate Downscaling Experiment (CORDEX) framework. This ensemble comprises five different Earth System Model/Regional Climate Model (ESM/RCM) combinations with three different ESMs and two RCMs. We show that all five compound climate extremes will increase in frequency, with changes being greater under RCP8.5 than RCP2.6. Moreover, populations exposed to these changes are greater under RCP8.5/SSP3, than RCP2.6/SSP1, increasing by 47‐ and 12‐fold, respectively, compared to the present‐day. Regions of Africa that are particularly exposed are West Africa, Central‐East Africa, and Northeast and Southeast Africa. Increased exposure is mainly driven by the interaction between climate and population growth, and the effect of population alone. This has important policy implications in relation to climate mitigation and adaptation.
Simple Global Ocean Biogeochemistry With Light, Iron, Nutrients and Gas Version 2 (BLINGv2): Model Description and Simulation Characteristics in GFDL's CM4.0
Authors: Dunne J. P. , Bociu I. , Bronselaer B. , Guo H. , John J. G. , Krasting J. P. , Stock C. A. , Winton M. , Zadeh N. 
Published: August 2020

AbstractSimulation of coupled carbon‐climate requires representation of ocean carbon cycling, but the computational burden of simulating the dozens of prognostic tracers in state‐of‐the‐art biogeochemistry ecosystem models can be prohibitive. We describe a six‐tracer biogeochemistry module of steady‐state phytoplankton and zooplankton dynamics in Biogeochemistry with Light, Iron, Nutrients and Gas (BLING version 2) with particular emphasis on enhancements relative to the previous version and evaluate its implementation in Geophysical Fluid Dynamics Laboratory's (GFDL) fourth‐generation climate model (CM4.0) with ¼° ocean. Major geographical and vertical patterns in chlorophyll, phosphorus, alkalinity, inorganic and organic carbon, and oxygen are well represented. Major biases in BLINGv2 include overly intensified production in high‐productivity regions at the expense of productivity in the oligotrophic oceans, overly zonal structure in tropical phosphorus, and intensified hypoxia in the eastern ocean basins as is typical in climate models. Overall, while BLINGv2 structural limitations prevent sophisticated application to plankton physiology, ecology, or biodiversity, its ability to represent major organic, inorganic, and solubility pumps makes it suitable for many coupled carbon‐climate and biogeochemistry studies including eddy interactions in the ocean interior. We further overview the biogeochemistry and circulation mechanisms that shape carbon uptake over the historical period. As an initial analysis of model historical and idealized response, we show that CM4.0 takes up slightly more anthropogenic carbon than previous models in part due to enhanced ventilation in the absence of an eddy parameterization. The CM4.0 biogeochemistry response to CO2doubling highlights a mix of large declines and moderate increases consistent with previous models.
Nearly Half of Global Vegetated Area Experienced Inconsistent Vegetation Growth in Terms of Greenness, Cover, and Productivity
Authors: Ding Zihan , Peng Jian , Qiu Sijing , Zhao Yan 
Published: August 2020

AbstractThe considerable interest in detecting global vegetation changes based on satellite observations is increasing. However, studies rely on single indices to explore the driving mechanisms of the greening trend might exacerbate uncertainties of global ecosystem change. Thus, vegetation growth dynamics from various biophysical properties required to be monitored comprehensively. In this study, a consistent framework for evaluating vegetation growth trends was developed based on five widely used satellite‐derived products of MODIS Collection 6; the consistency in vegetation growth was mapped; and the factors that affected the consistency of vegetation growth were explored. The results showed that, during 2000‐2015, 45.6% of global vegetated area experienced inconsistent trends in vegetation greenness, cover and productivity, especially in evergreen broadleaf forests, grasslands, open shrublands, woody savannas and croplands. Only 5.4% of global vegetated area exhibited simultaneous trends in greenness, cover and productivity, and the inconsistent areas were expanding in the study period. Contradictory vegetation changes were mainly reflected in the opposite trends of vegetation greenness and productivity in evergreen broadleaf forests. Moreover, the inconsistency change was mainly manifested in the greenness‐dominated vegetation enhancement, without enhanced productivity. The increment difference between NPP and GPP also showed respiration losses greatly offset the effect of vegetation greenness or cover on productivity. This study provides integrated insights for understanding the inconsistency of vegetation structural and functional changes in the context of global greening.
Gelatinous Zooplankton‐Mediated Carbon Flows in the Global Oceans: A Data‐Driven Modeling Study
Authors: Luo Jessica Y. , Condon Robert H. , Stock Charles A. , Duarte Carlos M. , Lucas Cathy H. , Pitt Kylie A. , Cowen Robert K. 
Published: August 2020

AbstractAmong marine organisms, gelatinous zooplankton (GZ; cnidarians, ctenophores, and pelagic tunicates) are unique in their energetic efficiency, as the gelatinous body plan allows them to process and assimilate high proportions of oceanic carbon. Upon death, their body shape facilitates rapid sinking through the water column, resulting in carcass depositions on the seafloor (“jelly‐falls”). GZ are thought to be important components of the biological pump, but their overall contribution to global carbon fluxes remains unknown. Using a data‐driven, three‐dimensional, carbon cycle model resolved to a 1° global grid, with a Monte Carlo uncertainty analysis, we estimate that GZ consumed 7.9–13 Pg C y−1in phytoplankton and zooplankton, resulting in a net production of 3.9–5.8 Pg C y−1in the upper ocean (top 200 m), with the largest fluxes from pelagic tunicates. Non‐predation mortality (carcasses) comprised 25% of GZ production, and combined with the much greater fecal matter flux, total GZ particulate organic carbon (POC) export at 100 m was 1.6–5.2 Pg C y−1, equivalent to 32–40% of the global POC export. The fast sinking GZ export resulted in a high transfer efficiency (Teff) of 38–62% to 1,000 m and 25–40% to the seafloor. Finally, jelly‐falls at depths >50 m are likely unaccounted for in current POC flux estimates and could increase benthic POC flux by 8–35%. The significant magnitude of and distinct sinking properties of GZ fluxes support a critical yet underrecognized role of GZ carcasses and fecal matter to the biological pump and air‐sea carbon balance.
Telescopic Observations of Lunar Hydration: Variations and Abundance
Authors: Honniball C. I. , Lucey P. G. , Ferrari‐Wong C. M. , Flom A. , Li S. , Kaluna H. M. , Takir D. 
Published: August 2020

AbstractPrior to 2009, the surface of the Moon was believed to be anhydrous. However, observations by three spacecraft revealed a hydrated surface by reporting a 3 μm absorption band attributed to hydroxyl and possibly molecular water. The Moon Mineralogy Mapper (M3) spectrometer on board the Chandrayaan‐1 spacecraft has been used to study the lunar 3 μm band, but its spectral range ends at 3 μm. The limited wavelength range of M3 has allowed observed variations in the strength of the 3 μm band to be called into question due to uncertainties in thermal corrections. To investigate the validity of variations in the lunar 3 μm band, we used the SpeX infrared spectrograph at the NASA InfraRed Telescope Facility at Maunakea Observatory in Hawai‘i. With SpeX, we are able to obtain lunar data over a wavelength range of 1.67 to 4.2 μm at 1–2 km spatial resolution. The long wavelengths provide strong constraints on separating thermal emission from solar reflectance. We confirm that the 3 μm band varies with lunar time of day as well as with latitude and composition. Pole‐to‐pole observation chords reveal strong variations in abundances of hydroxyl and possibly molecular water. The data reveal a decrease in abundance as lunar noon is approached, an asymmetric trend about the equator that favors the southern latitudes, and higher concentrations in highland regions. The longer wavelengths provided by SpeX have allowed us to examine variations in the 3 μm band and provide definitive evidence that the variations are due to changes in hydration.
Melatonin stimulates aromatase expression and estradiol production in human granulosa-lutein cells: relevance for high serum estradiol levels in patients with ovarian hyperstimulation syndrome
Authors: Cheng Jung-Chien , Fang Lanlan , Li Yiran , Wang Sijia , Li Yuxi , Yan Yang , Jia Qiongqiong , Wu Ze , Wang Zhen , Han Xiaoyu , Sun Ying-Pu 
Published: August 2020

AbstractOvarian hyperstimulation syndrome (OHSS) is one of the most life-threatening and potentially fatal complications associated with controlled ovarian hyperstimulation (COH) during in vitro fertilization (IVF) treatment. Although the pathogenesis of OHSS remains unclear, elevated serum estradiol (E2) levels before human chorionic gonadotropin (hCG) administration are associated with the risk of OHSS. The pineal hormone melatonin and its receptors are expressed in human granulosa cells and have been shown to stimulate E2 production. However, the effect of melatonin on the expression of aromatase, an enzyme responsible for a key step in the biosynthesis of E2, in human granulosa cells remains to be determined. Here, we demonstrate that melatonin upregulates aromatase expression in primary cultured human granulosa-lutein (hGL) cells through the melatonin receptor-mediated PKA-CREB pathway. Using a mouse model of OHSS, we demonstrate that administration of the melatonin receptor inhibitor luzindole inhibits the development of OHSS. In addition, the expression of ovarian aromatase and serum E2 levels are upregulated in OHSS mice compared to control mice, but this upregulation is attenuated by inhibition of the function of melatonin. Moreover, clinical results reveal that aromatase expression levels are upregulated in hGL cells from OHSS patients. Melatonin and E2 levels in the follicular fluid are significantly higher in OHSS patients than in non-OHSS patients. Furthermore, melatonin levels are positively correlated with E2 levels in follicular fluid. This study helps to elucidate the mechanisms mediating the expression of aromatase in hGL cells and provides a potential mechanism explaining the high E2 levels in patients with OHSS.
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action
Authors: McFarland James M. , Paolella Brenton R. , Warren Allison , Geiger-Schuller Kathryn , Shibue Tsukasa , Rothberg Michael , Kuksenko Olena , Colgan William N. , Jones Andrew , Chambers Emily , Dionne Danielle , Bender Samantha , Wolpin Brian M. , Ghandi Mahmoud , Tirosh Itay , Rozenblatt-Rosen Orit , Roth Jennifer A. , Golub Todd R. , Regev Aviv , Aguirre Andrew J. , Vazquez Francisca , Tsherniak Aviad 
Published: August 2020

AbstractAssays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate. Information-rich assays, such as gene-expression profiling, have generally not permitted efficient profiling of a given perturbation across multiple cellular contexts. Here, we develop MIX-Seq, a method for multiplexed transcriptional profiling of post-perturbation responses across a mixture of samples with single-cell resolution, using SNP-based computational demultiplexing of single-cell RNA-sequencing data. We show that MIX-Seq can be used to profile responses to chemical or genetic perturbations across pools of 100 or more cancer cell lines. We combine it with Cell Hashing to further multiplex additional experimental conditions, such as post-treatment time points or drug doses. Analyzing the high-content readout of scRNA-seq reveals both shared and context-specific transcriptional response components that can identify drug mechanism of action and enable prediction of long-term cell viability from short-term transcriptional responses to treatment.
Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum
Authors: Kubiasová Karolina , Montesinos Juan Carlos , Šamajová Olga , Nisler Jaroslav , Mik Václav , Semerádová Hana , Plíhalová Lucie , Novák Ondřej , Marhavý Peter , Cavallari Nicola , Zalabák David , Berka Karel , Doležal Karel , Galuszka Petr , Šamaj Jozef , Strnad Miroslav , Benková Eva , Plíhal Ondřej , Spíchal Lukáš 
Published: August 2020

AbstractPlant hormone cytokinins are perceived by a subfamily of sensor histidine kinases (HKs), which via a two-component phosphorelay cascade activate transcriptional responses in the nucleus. Subcellular localization of the receptors proposed the endoplasmic reticulum (ER) membrane as a principal cytokinin perception site, while study of cytokinin transport pointed to the plasma membrane (PM)-mediated cytokinin signalling. Here, by detailed monitoring of subcellular localizations of the fluorescently labelled natural cytokinin probe and the receptor ARABIDOPSIS HISTIDINE KINASE 4 (CRE1/AHK4) fused to GFP reporter, we show that pools of the ER-located cytokinin receptors can enter the secretory pathway and reach the PM in cells of the root apical meristem, and the cell plate of dividing meristematic cells. Brefeldin A (BFA) experiments revealed vesicular recycling of the receptor and its accumulation in BFA compartments. We provide a revised view on cytokinin signalling and the possibility of multiple sites of perception at PM and ER.
Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
Authors: Lee Joongoo , Schwarz Kevin J. , Kim Do Soon , Moore Jeffrey S. , Jewett Michael C. 
Published: August 2020

AbstractRibosome-mediated polymerization of backbone-extended monomers into polypeptides is challenging due to their poor compatibility with the translation apparatus, which evolved to use α-L-amino acids. Moreover, mechanisms to acylate (or charge) these monomers to transfer RNAs (tRNAs) to make aminoacyl-tRNA substrates is a bottleneck. Here, we rationally design non-canonical amino acid analogs with extended carbon chains (γ-, δ-, ε-, and ζ-) or cyclic structures (cyclobutane, cyclopentane, and cyclohexane) to improve tRNA charging. We then demonstrate site-specific incorporation of these non-canonical, backbone-extended monomers at the N- and C- terminus of peptides using wild-type and engineered ribosomes. This work expands the scope of ribosome-mediated polymerization, setting the stage for new medicines and materials.
Ultrafast terahertz saturable absorbers using tailored intersubband polaritons
Authors: Raab Jürgen , Mezzapesa Francesco P. , Viti Leonardo , Dessmann Nils , Diebel Laura K. , Li Lianhe , Davies A. Giles , Linfield Edmund H. , Lange Christoph , Huber Rupert , Vitiello Miriam S. 
Published: August 2020

AbstractSemiconductor heterostructures have enabled a great variety of applications ranging from GHz electronics to photonic quantum devices. While nonlinearities play a central role for cutting-edge functionality, they require strong field amplitudes owing to the weak light-matter coupling of electronic resonances of naturally occurring materials. Here, we ultrastrongly couple intersubband transitions of semiconductor quantum wells to the photonic mode of a metallic cavity in order to custom-tailor the population and polarization dynamics of intersubband cavity polaritons in the saturation regime. Two-dimensional THz spectroscopy reveals strong subcycle nonlinearities including six-wave mixing and a collapse of light-matter coupling within 900 fs. This collapse bleaches the absorption, at a peak intensity one order of magnitude lower than previous all-integrated approaches and well achievable by state-of-the-art QCLs, as demonstrated by a saturation of the structure under cw-excitation. We complement our data by a quantitative theory. Our results highlight a path towards passively mode-locked QCLs based on polaritonic saturable absorbers in a monolithic single-chip design.