bluuebunny/crossref_metadata_2025_split huggingface dataset:
Select clinical features in the craniofacial region in women with Turner syndrome
Authors: Frelich Jakub , Lepska Katarzyna , Jeż Wacław , Irzyniec Tomasz 
Published: January 2020

WSTĘP:Zespół Turnera (ZT) jest zaburzeniem chromosomalnym polegającym na obecności tylko jednego prawidłowego chromosomu X. Obejmuje on szeroki wachlarz chromosomalnych kariotypów i klinicznych fenotypów występujących także w obrębie twarzoczaszki.CEL:Celem jest przegląd piśmiennictwa dotyczącego typowych dla kobiet z ZT odchyleń od stanu prawidłowego
w badaniu podmiotowym i przedmiotowym w obrębie twarzoczaszki oraz występowania tych zmian w polskiej populacji kobiet z ZT o różnych kariotypach.MATERIAŁ I METODY:Dokonano przeglądu piśmiennictwa w bazie MEDLINE z lat 1989–2017 dotyczącego zmian
w obrębie twarzoczaszki u kobiet z ZT. Zbadano pomiary obwodów głowy i oceniono częstość występowania wybranych cech klinicznych zespołu Turnera w obszarze twarzoczaszki u 93 kobiet o kariotypie 45,X i 64 kobiet z pozostałymi kariotypami.WYNIKI:Obserwuje się istotne rozbieżności w piśmiennictwie odnośnie do częstości i nasilenia objawów ZT
w obszarze twarzoczaszki. Zwracają uwagę: częste występowanie retrognatyzmu, wysokie (gotyckie) podniebienie oraz informacje o trudnościach z karmieniem w dzieciństwie, ale również lepszy stan uzębienia kobiet z ZT niż w populacji ogólnej. Znamiennie większy obwód głowy kobiet z ZT z kariotypem 45,X niż u prezentujących pozostałe kariotypy, był jedynym parametrem znamiennie różnicującym grupy kobiet z ZT.WNIOSKI:1. Występowanie retrognatyzmu, wysokiego (gotyckiego) podniebienia oraz informacje o trudnościach
z karmieniem we wczesnym dzieciństwie mogłyby pełnić rolę objawów kluczy, sugerujących istnienie ZT. 2. Na podstawie analizy dostępnego piśmiennictwa oraz częstości występowania charakterystycznych dla zespołu Turnera anomalii w obszarze twarzoczaszki, stwierdzono, że nie da się ich powiązać z prezentowanym kariotypem.
SOCIEDADE DO CONHECIMENTO: O uso das TIC por docentes e as novas articulações de saberes educacionais no sudeste do Pará
Authors: Evangelista Francisco , Martins Karina Donizete , Angelini Maria Fernanda Calil , Rocha Maria Josilene Fontinele 
Published: January 2020

O presente estudo tem o propósito verificar a adesão dos docentes e os entraves na utilização das TIC no processo ensino e aprendizagem numa IES privada, contribuindo para a criação de novas práticas pedagógicas ou de uma ciberpedagogia confrontando com o moduz operandi na docência. A pesquisa utilizou-se de reuniões de grupos e aplicação de questionário para professores dos cursos de Administração, Biomedicina, Contábeis, Direito, Enfermagem, Serviço Social e Zootecnia. Os dados foram interpretados por meio do círculo hermenêutico dialético (CHD). Os sentidos extraídos das falas dos docentes apontam como resultados preliminares que a TIC estimula o estudo, otimiza tempo e trabalho, favorece a autonomia do estudante e a responsabilidade.

PALAVRAS-CHAVE: Ensino e aprendizagem; Tecnologias da informação e da comunicação; Prática docente; Formação docente.

ABSTRACT
The present study has the purpose of verifying the adherence of teachers and the obstacles to the use of ICT in the teaching and learning process in a private HEI, contributing to the creation of new pedagogical practices or a cyberpedagogy confronting the moduz operandi in teaching. The research used group meetings and questionnaire application for teachers of the courses of Administration, Biomedicine, Accounting, Law, Nursing, Social Service and Zootechnics. The data were interpreted through the dialectical hermeneutic circle (CHD). The senses extracted from the teachers' statements point as preliminary results that ICT stimulates the study, optimizes time and work, favors student autonomy and responsibility.

KEYWORDS: Teaching and learning; Information and communication Technologies; Teaching practice; Teacher training.

RESUMEN
El presente estudio tiene el propósito de verificar la adhesión de los docentes y los obstáculos a la utilización de las TIC en el proceso de enseñanza y aprendizaje en una IES privada, contribuyendo a la creación de nuevas prácticas pedagógicas o de una ciberpedagogía confrontando con el modesto operandi en la docencia. La investigación utilizó reuniones de grupos y aplicación de cuestionario para profesores de los cursos de Administración, Biomedicina, Contable, Derecho, Enfermería, Servicio Social y Zootecnia. Los datos fueron interpretados por medio del círculo hermenéutico dialéctico (CHD). Los sentidos extraídos de las palabras de los docentes apuntan como resultados preliminares que la TIC estimula el estudio, optimiza tiempo y trabajo, favorece la autonomía del estudiante y la responsabilidad.

PALABRAS CLAVE: Enseñanza y aprendizagem; Tecnologías de la información y la comunicación; Pratica docente; Formación docente.
VIDAS FOTOGRAFICAMENTE EDITADAS
Authors: Vicente Kyldes Batista , Sousa Fábio d'Abadia de 
Published: January 2020

Neste texto discutimos alguns aspectos relacionados ao uso de fotografias em redes sociais. A nossa abordagem questiona o fato de a fotografia ser apresentada de forma geralmente editada, a fim de passar uma impressão falseada daquilo que o internauta realmente é. A nossa discussão também chama a atenção para o fato de que as vidas perfeitas divulgadas nas fotografias pessoais postadas na rede mundial de computadores contribuem também para a implantação de preconceitos contra os que não se encaixam no padrão de aparência ditado. Partiremos de um texto poético e, por isso, traremos algumas reflexões acerca da literatura como arte e a literatura de Álvaro de Campos, heterônimo de Fernando Pessoa.

PALAVRAS-CHAVE: Fotografias; redes sociais; arte e literatura.

ABSTRACT
In this text we discuss some aspects related to the use of photographs in social networks. Our approach questions the fact that the photograph is presented in a generally edited way, in order to give a false impression of what the user really is. Our discussion also draws attention to the fact that the perfect lives revealed in personal photographs posted on the World Wide Web also contribute to the introduction of preconception against those who do not fit into the dictation appearance pattern. We will start with a poetic text and, therefore, we will bring some reflections about literature as art and the literature of Álvaro de Campos, heteronymous of Fernando Pessoa.

KEYWORDS: Photographs; social networks; art and literature.

RESUMEN
En ese texto discutimos algunos aspectos relacionados al uso de fotografías en redes sociales. Nuestro abordaje cuestiona el hecho de la fotografía ser presentada de forma generalmente editada, con el fin de transmitir una impresión falsa de aquello que el internauta realmente es. Nuestra discusión también llama la atención para el hecho de que las vidas perfectas divulgadas en las fotografías personales publicadas en la red mundial de computadoras contribuyen también para la implantación de prejuicios contra los que no se encajan en el patrón de apariencia dictado. Partiremos de un texto poético y, por ello, traemos algunas reflexiones acerca de la literatura como arte y la literatura de Álvaro de Campos, heterónimo de Fernando Pessoa.

PALABRAS CLAVE: Fotografías; redes sociales; arte y literatura.
GÊNERO E RAÇA NA COMUNICAÇÃO DE MARCAS: A dimensão política do consumo sob uma perspectiva interseccional
Authors: Fernandes Viana Pablo Moreno , Musa Belmiro Dalila Maria 
Published: January 2020

Este artigo analisa a comunicação de marcas que comercializam produtos para cabelos cacheados e crespos em comemoração ao Dia Internacional da Mulher e Dia da Consciência Negra em 2018. Baseados na origem das duas datas, estudamos as dimensões políticas do consumo, a partir de uma perspectiva interseccional entre gênero e raça. A análise semiótica de posts no Facebook de três marcas brasileiras discute a constituição da identidade das mulheres negras, seu lugar na sociedade, assim como empoderamento e consumo na contemporaneidade, em um país sexista e racista. Verificamos como as interseccionalidades são abordadas (ou apagadas), em um cenário que visa inserir negros nos discursos publicitários.

PALAVRAS-CHAVE: Identidade; Consumo; Interseccionalidade; Racismo; Feminismo Negro.

ABSTRACT
This article analyses the communication of brands that market products for curly and afro hair in celebration of International Women's Day and Black Awareness Day in 2018. Based in the origin of the two dates, we studied the political dimensions of consumerism, from an intersectional perspective between gender and race. The semiotic analysis of posts on Facebook of three Brazilian brands discusses the identity constitution of black women, their place in society, as well the empowerment and consumption in the contemporary, in a sexist and racist country. We verify how intersectionalities are approached (or erased), in a scenario that aims to insert black people in advertising discourses.

KEYWORDS: Identity; Consumerism; Intersectionality; Racism; Black Feminism.

RESUMEN
Este artículo analiza la comunicación de marcas que venden productos para el cabello crespo y rizado en celebración del Día Internacional de la Mujer y el Día de la Conciencia Negra en 2018. Basados en el origen de las dos fechas, estudiamos las dimensiones políticas del consumo desde una perspectiva interseccional entre género y raza. El análisis semiótico de las publicaciones en Facebook de tres marcas brasileñas estudia la constitución de la identidad de las mujeres negras, su lugar en la sociedad, así como el empoderamiento y el consumo en los tiempos contemporáneos, en un país sexista y racista. Verificamos cómo se abordan (o borran) la interseccionalidad, en un escenario que apunta a insertar negros en los discursos publicitarios.

PALABRAS CLAVE: Identidad; Consumen; Interseccionalidad; Racismo; Feminismo Negro.
INTERDISCIPLINARIDADE, CRITICIDADE E FORMAÇÃO SOCIOAMBIENTAL NA UNIVERSIDADE
Authors: Moraes Nelson Russo de , Souza Fernando da Cruz , Marchetti Cristiane Teixeira Bazílio , Moraes Felipe Góes de , Fonseca Joicileia Juliate 
Published: January 2020

A produção do conhecimento interdisciplinar é pauta central deste trabalho, que traz os desafios da sociedade contemporânea como pano de fundo para um debate sobre a importância do pensamento crítico e da educação socioambiental para a formação de um profissional mais completo em contraposição a muitos dos desejos concretos da organização social vigente. Esta comunicação científica desdobra-se dos trabalhos desenvolvidos no GEDGS (Grupo de Estudos em Democracia e Gestão Social) da UNESP a partir da tese e textos de defesa de linha de pesquisa para a obtenção do título de livre-docente em Gestão e Educação Ambiental do Prof. Dr. Nelson Russo de Moraes, na FCE/UNESP, em setembro de 2019. Conclui em defesa de que, independentemente da área de formação, é importante a instrumentalização do pensamento crítico e o amadurecimento de um olhar socioambiental sobre diferentes grupamentos humanos.

PALAVRAS-CHAVE: Educação socioambiental. Gestão social. Formação crítica.

ABSTRACT
The production of interdisciplinary knowledge is the central theme of this work, which brings the challenges of contemporary society as a background for a debate on the importance of critical thinking and socio-environmental education for the formation of a more complete professional in opposition to many of the concrete desires. of the current social organization. This scientific communication unfolds from the works developed at UNESP's GEDGS (Study Group on Democracy and Social Management) from the thesis and texts of defense of the research line to obtain the title of professor in Environmental Management and Education of PhD Nelson Russo de Moraes, FCE / UNESP, September 2019. Concludes in defense that, regardless of the area of ​​formation, the instrumentalization of critical thinking and the maturation of a socio-environmental perspective on different human groups is important.

KEYWORDS: Social and environmental education. Social management. Critical formation.
TECNOLOGIAS DIGITAIS E EDUCAÇÃO: impactos e desafios para uma nova configuração de subjetividade
Authors: Santos Elaine Moraes , Lastória Luiz Antonio Calmon Nabuco 
Published: January 2020

Este trabalho pretende problematizar à luz da Teoria Crítica da Sociedade os impactos e desafios que o atual regime de vida apoiado no uso das tecnologias digitais traz para o campo da educação, com o intuito de que esta investigação possibilite um novo olhar metodológico sobre a utilização destes recursos em prol de um ambiente escolar que reconecte o espaço alargado entre os tradicionais moldes de ensino e a nova subjetividade e identidade contemporânea do alunado.

PALAVRAS-CHAVE: Tecnologias digitais; Educação; Impactos; subjetividade

ABSTRACT
This work is designed to problematize in the light of the Critical Theory of the Society of the impacts and challenges that the current regime of life supported without the use of the digital technologies brings to the field of education, with the intention that this investigation allows a new methodological look on one of these resources in favor of a school environment that covers the wide space between the translators of teaching and new subjectivity and contemporary identity of the student.

KEYWORDS: Digital technologies; Education; Impacts; subjectivity

RESUMENEste trabajo pretende problematizar a la luz de la Teoría Crítica de la Sociedad los impactos y desafíos que el actual régimen de vida apoyado en el uso de las tecnologías digitales trae al campo de la educación, con el propósito de que esta investigación posibilite una nueva mirada metodológica sobre la utilización de éstos recursos en pro de un ambiente escolar que reconecte el espacio ampliado entre los tradicionales moldes de enseñanza y la nueva subjetividad e identidad contemporánea del alumnado.

PALABRAS CLAVE: Tecnologías digitales; Educación; Impactos; subjetividad.
3D Geomechanical Evaluation of Jetting Operations for Producing Hydrate Chimneys in the Sea of Japan
Authors: Zhang Pengwei , Qiu Kaibin , Yoshihiro Terao , Kashihara Koji 
Published: January 2020

Summary
The common occurrence of massive methane hydrate in numerous gas-chimney structures, located in Joetsu Basin, Sea of Japan, has stimulated great interest in academia, industry, and national institutes to develop technologies that produce the potential energy resource. Unlike other deep methane-hydrate deposits in formations a few hundred meters below the seafloor (mBSF), the hydrate-chimney structures are at the seafloor or up to 100 mBSF; therefore, previously field-tested production methods such as depressurization are not applicable. In this work, we proposed a new potential production method of jetting from the openhole section of a wellbore to excavate the hydrate bearing. However, jetting will create large empty chambers below the seafloor and could possibly jeopardize the stability and safety of wellheads and the production facility on the seafloor.
This paper presents a 3D geomechanical simulation study to evaluate the feasibility of the jetting method to produce methane from the hydrate chimneys in the Sea of Japan. In this work, we constructed three types of 3D geomechanical models to represent three shallow-methane-hydrate-inhabitation types (chunk, laminated, and dispersed) by using data from various sources. Dynamic numerical simulation using a 3D finite-element simulator was conducted to simulate the jetting process to excavate a 16-m-diameter chamber from the bottom of the borehole (approximately 100 mBSF) progressively up to the bottom of the conductor of the wellbore, approximately 10 mBSF.
The numerical simulation shows that jetting is likely to be feasible because all simulation cases resulted in tolerable vertical displacement and equivalent plastic strain under ideal conditions [e.g., lateral homogeneous formation, constant chamber pressure (equal to formation pore pressure), and blowout-preventer (BOP) weight of 20 tons]. In these cases, the plastic zone only extends to a limited area (10–20 cm) from the sidewall. Additional complexities were considered in the numerical simulation to evaluate the operational risks during actual jetting operations, such as faulting, fluctuation of chamber pressure, and change of BOP weights.
This numerical simulation evaluated potential risks related to jetting operations of hydrate chimneys in the Sea of Japan and provided critical information for the engineering design of the proposed field test of jetting operations to produce this valuable resource in the Sea of Japan.
Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)
Authors: Chen Lulu , Yuan Mingzhen , Sun Lu , Wang Yuelin , Chen Youxin 
Published: January 2020

Abstract
Purpose: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients.
Methods: Forty-seven unilateral BRVO patients and forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes, fellow eyes and control eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal vessel density 300 (FD-300) were measured.
Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes (P<0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P<0.05). VD of SVC and FD-300 were lower in fellow eyes compared with normal control eyes (P<0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes (P<0.05). VD of inside disc in fellow eyes was lower than normal eyes (P<0.05).
Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Unaffected eyes of unilateral BRVO showed vascular abnormalities in superficial retinal layer, peri-FAZ area and also peripapillary regions.
Key words: optical coherence tomography angiography, retinal vasculature, foveal avascular zone, radial peripapillary capillary, branch retinal vein occlusion
Does long-term recreational gymnastics prevent injurious falls in older women? A prospective 20-year follow-up
Authors: Uusi-Rasi Kirsti , Karinkanta Saija , Kannus Pekka , Tokola Kari , Sievänen Harri 
Published: January 2020

Abstract
Background

: Exercise interventions focused on balance and strength training have been shown to be effective for falls prevention. The aim of this 20-year register-based follow-up was to examine whether long-term participation in recreational female gymnastics is associated with a lower risk of medically-attended injurious falls.

Methods

: Health care register data of 187 women (103 recreational gymnasts and 84 sedentary controls) from the original cohort of 243 women were assessed. The mean age (sd) at baseline was 62.8 (5.4) years and the mean follow-up time was 19.4 (2.7) years (range from 5.6 to 21.0 years).

Injurious falls were scrutinized from medical records. An injurious fall was defined as an event in which falling was mentioned as a reason for making contact with the health-care professionals. Negative binomial regression was used to estimate incidence rate ratios (IRR) for injurious falls, and Cox-regression models for calculating hazard ratios (HR) for injured fallers with the control group as reference.

Results

Recreational gymnasts had about 30% less injurious falls compared to controls, the mean IRR (95% CI) being 0.71 (0.51 to 0.96). Regarding injured fallers, the HR was 0.73 (0.52 to 1.02) favoring the recreational gymnasts. There were no statistically significant between-group differences for fractures.

Conclusion

s: Long-term recreational gymnastics appears to reduce the risk of injurious falls in old age.
NMDA Receptor-mediated CaMKII/ERK Activation Contributes to Renal Fibrosis
Authors: Zhou Jingyi , Liu Shuaihui , Guo Luying , Wang Rending , Chen Jianghua , Shen Jia 
Published: January 2020

Abstract
Background: Renal fibrosis (RF) results in renal function impairment and eventually kidney failure. We found that N-methyl-D-aspartate receptor (NMDAR) played an important role during RF. However, its mechanism of action is yet to be deciphered.

Methods: Acute RF was induced in mice by unilateral ureteral obstruction (UUO). NR1, which is the functional subunit of NMDAR, was downregulated using lentiviral vector-mediated shRNA interference. Histological changes were observed by Masson’s trichrome staining. Expression of NR1, fibrotic and EMT markers were measured by immunohistochemistry and western blot analysis. HK-2 cells were incubated with TGF-β, and NMDAR antagonist MK-801 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) antagonist KN-93 administration were further included in this study for pathway determination. Expression of NR1, total and phosphorylated CaMKII, total and phosphorylated ERK were measured using western blot and immunofluorescent assays. Chronic renal fibrosis was introduced by sublethal ischemia-reperfusion injury in mice, and oral NMDAR inhibitor dextromethorphan (DXM) administration was performed.

Results: NR1 expressions were upregulated in both obstructed kidneys and TGF-β treated HK-2 cells. NR1 knockdown, DXM, MK801, and KN93 reduced the fibrotic morphology in vivo and in vitro respectively, and companied with the downregulated ERK activation, while KN93 administration had no effect on NR1 and CaMKII levels.

Conclusions: NMDAR participates in both acute and chronic renal fibrogenesis via CaMKII/ERK activation, and is a potential therapeutic target for renal fibrosis.
Emerging coexistence of three PMQR genes on a multiple resistance plasmid with a new surrounding genetic structure of qnrS2 in E. coli in China
Authors: tao ying , zhou kaixin , xie lianyan , xu yanping , han lizhong , ni yuxing , qu jieming , sun jingyong 
Published: January 2020

Abstract
Background: Quinolones are commonly used for treatment of infections by bacteria of the Enterobacteriaceae family. However, the rising resistance to quinolones worldwide poses a major clinical and public health risk. This study aimed to characterise a novel multiple resistance plasmid carrying three plasmid-mediated quinolone resistance genes in Escherichia coli clinical stain RJ749. Methods: MICs of ceftriaxone, cefepime, ceftazidime, ciprofloxacin, and levofloxacin for RJ749 and transconjugant c749 were determined by the Etest method. Conjugation was performed using sodium azide-resistant E. coli J53 strain as a recipient. The quinolone resistance-determining regions of gyrA, gyrB, parC, and parE were PCR-amplified. Results: RJ749 was highly resistant to quinolones, while c749 showed low-level resistance. S1-nuclease pulsed-field gel electrophoresis revealed that RJ749 and c749 both harboured a plasmid. PCR presented chromosomal mutation sites of the quinolone resistance-determining region, which mediated quinolone resistance. The c749 genome comprised a single plasmid, pRJ749, with a multiple resistance region, including three plasmid-mediated quinolone resistance (PMQR) genes (aac(6′)-Ib-cr, qnrS2, and oqxAB) and ten acquired resistance genes. One of the genes, qnrS2, was shown for the first time to be flanked by two IS26s. Three IS26-mediated circular molecules carrying the PMQR genes were detected. Conclusions: We revealed the coexistence of three PMQR genes on a multiple resistance plasmid and a new surrounding genetic structure of qnrS2 flanked by IS26 elements. IS26 plays an important role in horizontal spread of quinolone resistance.