bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trabajadora/e/s Sociales como sujetos políticos, una apuesta desde la reconceptualización latinoamericana
Authors: Bautista Joaqui Haider Esteban , Castillo Niño Joseph Vicent 
Published: December 2020

El presente artículo pretende evidenciar algunas reflexiones sobre la necesidad del profesionalen Trabajo Social como sujeto político en la cotidianidad ante la arremetida del modelo neoliberal. El objetivo fue establecer la relación entre el movimiento de reconceptualización y la construcción de un/a trabajador/a social como sujeto político acorde a la cuestión social. Se empleó una revisión bibliográfica de carácter cualitativa en diversas bases de datos y mediante múltiples buscadores académicos. Se presenta el contexto socio-histórico del proceso de la reconceptualización en Latinoamérica. Sumada una búsqueda sobre las implicaciones de ser sujeto social y la comprensión de la cuestión social de cara a nuevas representaciones de la desigualdad social. Luego, una articulación y reflexión de las categoríasseñaladas anteriormente dando un apartado de discusión donde son expuestos algunos argumentosque sustentan el objetivo central de la investigación. A manera de conclusión, se destaca la necesidadde ser sujeto político desde la formación y ejercicio profesional frente a las nuevas representacionesde la cuestión social en concordancia con la vigencia de los aportes realizados por el movimiento de lareconceptualización (1960-1970). Se finaliza la discusión con una invitación para ampliar y fortalecer el área de investigación como una apuesta ético-política
This article aims to highlight some reflections on the need of the social worker as a political subject in all his professional actions, is a qualitative research, conducted under a documentary review in various databases and repositories, indexed books and journals, both nationally and internationally. It is divided into a review of the socio-historical context of the process of reconceptualization and its contributions to the construction of critical social work, a review of the importance and implications of being a social subject, the understanding of the social question emanating from a capitalist model that constantly generates inequalities and precarious living conditions for a large part of the world’s population, followed by an articulation and reflection of the categories outlined above, finally, conclusions are presented that point to the need to be a political subject from the training and professional practice as a response to the community and in accordance with the validity of the reconceptualization as an emancipating struggle for the social subjects that see afectted their integrity and the guarantee of their human rights, calling on him or the professional in Social Work, to be a participant in the processes he carries out and not seen as a third , oblivious to that reality, to conclude the invitation is extended to expand and strengthen the area of research as an ethical-political bet.
Les incarnations de Barbara Hannigan, artiste plurielle
Authors: L’Écuyer Sylvia 
Published: December 2020

Soprano, cheffe d’orchestre, muse, directrice artistique, mentore, la Canadienne Barbara Hannigan mène à tous égards une carrière exceptionnelle pour son éclectisme, pour le niveau incontestable d’excellence de ses réalisations et pour l’énergie inépuisable qui semble l’habiter. Catapultée au statut de superstar par une renversante interprétation du rôle de Lulu à Bruxelles, en 2012, nommée « artiste Étoile » au Festival de Lucerne en 2014, lauréate du Glasshütte Original MusicFestivalAward en 2020, Hannigan a créé plus de 85 oeuvres, en grande partie écrites pour elle. En 2017, elle lançait Equilibrium (eq), un programme de mentorat unique destiné à un petit groupe de jeunes artistes en début de carrière qu’elle sélectionne elle-même. En assistant aux ateliers eq, l’auteure a observé qu’en plus d’encourager ces musiciens à aborder la carrière avec confiance, discipline et joie et à s’entourer de partenaires artistiques stimulants, Hannigan leur offre d’être leur première partenaire dans les projets novateurs qu’elle continue d’embrasser.
HSP90 identified by a proteomic approach as druggable target to reverse platinum resistance in ovarian cancer
Authors: Lombardi Rita , Sonego Maura , Pucci Biagio , Addi Laura , Iannelli Federica , Capone Francesca , Alfano Luigi , Roca Maria Serena , Milone Maria Rita , Moccia Tania , Costa Alice , Di Gennaro Elena , Bruzzese Francesca , Baldassarre Gustavo , Budillon Alfredo 
Published: December 2020

Acquired resistance to platinum (Pt)‐based therapies is an urgent unmet need in the management of epithelial ovarian cancer (EOC) patients. Here, we characterized by an unbiased proteomics method three isogenic EOC models of acquired Pt resistance (TOV‐112D, OVSAHO, and MDAH‐2774). Using this approach, we identified several differentially expressed proteins in Pt‐resistant (Pt‐res) compared to parental cells and the chaperone HSP90 as a central hub of these protein networks. Accordingly, up‐regulation of HSP90 was observed in all Pt‐res cells and heat‐shock protein 90 alpha isoform knockout resensitizes Pt‐res cells to cisplatin (CDDP) treatment. Moreover, pharmacological HSP90 inhibition using two different inhibitors [17‐(allylamino)‐17‐demethoxygeldanamycin (17AAG) and ganetespib] synergizes with CDDP in killing Pt‐res cells in all tested models. Mechanistically, genetic or pharmacological HSP90 inhibition plus CDDP ‐induced apoptosis and increased DNA damage, particularly in Pt‐res cells. Importantly, the antitumor activities of HSP90 inhibitors (HSP90i) were confirmed both ex vivo in primary cultures derived from Pt‐res EOC patients ascites and in vivo in a xenograft model. Collectively, our data suggest an innovative antitumor strategy, based on Pt compounds plus HSP90i, to rechallenge Pt‐res EOC patients that might warrant further clinical evaluation.
A comprehensive meta‐analysis of the comparison question polygraph test
Authors: Honts Charles R. , Thurber Steven , Handler Mark 
Published: December 2020

AbstractWe conducted a meta‐analysis on the most commonly used forensic polygraph test, the Comparison Question Test. We captured as many studies as possible by using broad inclusion criteria. Data and potential moderators were coded from 138 datasets. The meta‐analytic effect size including inconclusive outcomes was 0.69 [0.66, 0.79]. We found significant moderator effects. Notably, level of motivation had a positive linear relationship with our outcome measures. Information Gain analysis of CQT outcomes representing the median accuracy showed a significant information increase over interpersonal deception detection across almost the complete range of base rates. Our results suggest that the CQT can be accurate, that experimental studies are generalizable, and no publication bias was detected. We discussed the limitations of the field research literature and problems within polygraph profession that lower field accuracy. We suggest some possible solutions.
Nanoporous Surface High‐Entropy Alloys as Highly Efficient Multisite Electrocatalysts for Nonacidic Hydrogen Evolution Reaction
Authors: Yao Rui‐Qi , Zhou Yi‐Tong , Shi Hang , Wan Wu‐Bin , Zhang Qing‐Hua , Gu Lin , Zhu Yong‐Fu , Wen Zi , Lang Xing‐You , Jiang Qing 
Published: December 2020

AbstractElectrocatalytic hydrogen evolution in alkaline and neutral media offers the possibility of adopting platinum‐free electrocatalysts for large‐scale electrochemical production of pure hydrogen fuel, but most state‐of‐the‐art electrocatalytic materials based on nonprecious transition metals operate at high overpotentials. Here, a monolithic nanoporous multielemental CuAlNiMoFe electrode with electroactive high‐entropy CuNiMoFe surface is reported to hold great promise as cost‐effective electrocatalyst for hydrogen evolution reaction (HER) in alkaline and neutral media. By virtue of a surface high‐entropy alloy composed of dissimilar Cu, Ni, Mo, and Fe metals offering bifunctional electrocatalytic sites with enhanced kinetics for water dissociation and adsorption/desorption of reactive hydrogen intermediates, and hierarchical nanoporous Cu scaffold facilitating electron transfer/mass transport, the nanoporous CuAlNiMoFe electrode exhibits superior nonacidic HER electrocatalysis. It only takes overpotentials as low as ≈240 and ≈183 mV to reach current densities of ≈1840 and ≈100 mA cm−2 in 1 m KOH and pH 7 buffer electrolytes, respectively; ≈46‐ and ≈14‐fold higher than those of ternary CuAlNi electrode with bimetallic Cu–Ni surface alloy. The outstanding electrocatalytic properties make nonprecious multielemental alloys attractive candidates as high‐performance nonacidic HER electrocatalytic electrodes in water electrolysis.
The Interlayer Method: A Universal Tool for Energy Level Alignment Tuning at Inorganic/Organic Semiconductor Heterojunctions
Authors: Schultz Thorsten , Lungwitz Dominique , Longhi Elena , Barlow Stephen , Marder Seth R. , Koch Norbert 
Published: December 2020

AbstractThe combination of inorganic and organic semiconductors in a heterojunction is considered a promising approach to overcome limitations of each individual material class. However, to date only few examples of improved (opto‐)electronic functionality have been realized with such hybrid heterojunctions. The key to unraveling the full potential offered by inorganic/organic semiconductor heterojunctions is the ability to deliberately control the interfacial electronic energy levels. Here, a universal approach to adjust the offset between the energy levels at inorganic/organic semiconductor interfaces is demonstrated: the interlayer method. A monolayer‐thick interlayer comprising strong electron donor or acceptor molecules is inserted between the two semiconductors and alters the energy level alignment due to charge transfer with the inorganic semiconductor. The general applicability of this method by tuning the energy levels of hydrogenated silicon relative to those of vacuum‐processed films of a molecular semiconductor as well as solution‐processed films of a polymer semiconductor is exemplified, and is shown that the energy level offset can be changed by up to 1.8 eV. This approach can be used to adjust the energy levels at the junction of a desired material pair at will, and thus paves the way for novel functionalities of optoelectronic devices.
Recent Progress in Magnetically Actuated Microrobots for Targeted Delivery of Therapeutic Agents
Authors: Choi Junhee , Hwang Junsun , Kim Jin‐young , Choi Hongsoo 
Published: December 2020

AbstractTherapeutic agents, such as drugs and cells, play an essential role in virtually every treatment of injury, illness, or disease. However, the conventional practices of drug delivery often result in undesirable side effects caused by drug overdose and off‐target delivery. In the case of cell delivery, the survival rate of the transplanted cells is extremely low and difficulties with the administration route of cells remain a problem. Recently, magnetically actuated microrobots have started offering unique opportunities in targeted therapeutic delivery due to their tiny size and ability to access hard‐to‐reach lesions in a minimally invasive manner; considerable advances in this regard have been made over the past decade. Here, recent progress in magnetically actuated microrobots, developed for targeted drug/cell delivery, is presented, with a focus on their design features and mechanisms for controlled therapeutic release. Additionally, the practical challenges faced by the microrobots, and future research directions toward the swift bench‐to‐bedside translation of the microrobots are addressed.
Nanotheranostic Interface Based on Antibiotic‐Loaded Conducting Polymer Nanoparticles for Real‐Time Monitoring of Bacterial Growth Inhibition
Authors: Enshaei Hamidreza , Puiggalí‐Jou Anna , del Valle Luis J. , Turon Pau , Saperas Núria , Alemán Carlos 
Published: December 2020

AbstractConducting polymers have been increasingly used as biologically interfacing electrodes for biomedical applications due to their excellent and fast electrochemical response, reversible doping–dedoping characteristics, high stability, easy processability, and biocompatibility. These advantageous properties can be used for the rapid detection and eradication of infections associated to bacterial growth since these are a tremendous burden for individual patients as well as the global healthcare system. Herein, a smart nanotheranostic electroresponsive platform, which consists of chloramphenicol (CAM)‐loaded in poly(3,4‐ethylendioxythiophene) nanoparticles (PEDOT/CAM NPs) for concurrent release of the antibiotic and real‐time monitoring of bacterial growth is presented. PEDOT/CAM NPs, with an antibiotic loading content of 11.9 ± 1.3% w/w, are proved to inhibit the growth of Escherichia coli and Streptococcus sanguinis due to the antibiotic release by cyclic voltammetry. Furthermore, in situ monitoring of bacterial activity is achieved through the electrochemical detection of β‐nicotinamide adenine dinucleotide, a redox active specie produced by the microbial metabolism that diffuse to the extracellular medium. According to these results, the proposed nanotheranostic platform has great potential for real‐time monitoring of the response of bacteria to the released antibiotic, contributing to the evolution of the personalized medicine.
The Power of Ionic Liquids: Crystal Facet Engineering of SrTiO3Nanoparticles for Tailored Photocatalytic Applications
Authors: Alammar Tarek , Smetana Volodymr , Pei Hanwen , Hamm Ines , Wark Michael , Mudring Anja‐Verena 
Published: December 2020

AbstractSonochemical synthesis of nano‐sized SrTiO3carried out at close to room temperature, in ionic liquids (ILs) allows the tuning of particle size and particle morphology, that is, tracht and habitus, as well as particle aggregation via the choice of the ionic liquids (ILs) as the reaction medium. The nanoparticles demonstrate high performance for photocatalytic water splitting and photodecomposition of organic material. To this end bis(trifluoromethanesulfonyl)amide ([Tf2N]−)‐based ILs with cations of different properties with respect to specific interactions with the target material are investigated. Isolated, 15±1 nm sized nano‐spheres of SrTiO3are observed to form in [C3mimOH][Tf2N] ([C3mimOH]+ =1‐(3‐hydroxypropyl)‐3‐methylimidazolium). Aggregation of small sized nanoparticles are observed to around 250±100 nm large cube‐like formations in [C4mim][Tf2N] ([C4mim]+ =1‐butyl‐3‐methylimidazolium), raspberry‐like in [C4Py][Tf2N] ([C4Py]+butylpyridinium), and ball‐like in [P66614][Tf2N] ([P66614]+tetradecyltrihexyl phosphonium). Importantly, the different materials show different performance as photocatalysts. SrTiO3prepared in [C4mim][Tf2N] shows the highest photocatalytic activity for H2evolution (1115.4µmol h−1) when using 0.025 wt% Rh as the co‐catalyst, whereas the material prepared in [C3mimOH][Tf2N] shows the highest activity for the photocatalytic degradation of methylene blue (88%) under UV irradiation. The different photocatalytic activities can be correlated with the different crystal surface facets expressed in the respective nanosized SrTiO3material, {110} for material obtained from [C4mim][Tf2N], and {100} for material from [C3mimOH][Tf2N]. First‐principles density functional theory (DFT) calculations are used to support the experimental findings.
Surface Doping of Organic Single‐Crystal Semiconductors to Produce Strain‐Sensitive Conductive Nanosheets
Authors: Watanabe Shun , Hakamatani Ryohei , Yaegashi Keita , Yamashita Yu , Nozawa Han , Sasaki Mari , Kumagai Shohei , Okamoto Toshihiro , Tang Cindy G. , Chua Lay‐Lay , Ho Peter K. H. , Takeya Jun 
Published: December 2020

AbstractA highly periodic electrostatic potential, even though established in van der Waals bonded organic crystals, is essential for the realization of a coherent band electron system. While impurity doping is an effective chemical operation that can precisely tune the energy of an electronic system, it always faces an unavoidable difficulty in molecular crystals because the introduction of a relatively high density of dopants inevitably destroys the highly ordered molecular framework. In striking contrast, a versatile strategy is presented to create coherent 2D electronic carriers at the surface of organic semiconductor crystals with their precise molecular structures preserved perfectly. The formation of an assembly of redox‐active molecular dopants via a simple one‐shot solution process on a molecularly flat crystalline surface allows efficient chemical doping and results in a relatively high carrier density of 1013 cm−2 at room temperature. Structural and magnetotransport analyses comprehensively reveal that excellent carrier transport and piezoresistive effects can be obtained that are similar to those in bulk crystals.
Recent Advances and Perspectives of Zn‐Metal Free “Rocking‐Chair”‐Type Zn‐Ion Batteries
Authors: Tian Yuan , An Yongling , Wei Chuanliang , Xi Baojuan , Xiong Shenglin , Feng Jinkui , Qian Yitai 
Published: December 2020

AbstractIn the past decades, the world has witnessed the successful commercialization of “rocking‐chair”‐type lithium‐ion batteries with lithium metal free anodes. Owing to their safe, green, easy manufacturing, and cost‐efficiency characteristics, rechargeable zinc batteries have recently received more and more attention. However, the practical application of Zn metal batteries is hampered mainly by the dendritic growth of Zn metal anode, which leads to poor Coulombic efficiency, hazards, and various side reactions. Herein, the emerging “rocking‐chair”‐type Zn‐ion batteries are systemically reviewed with Zn host anodes instead of Zn metal anodes. As an introduction, the fundamental principles, advantages, and challenges of “rocking‐chair”‐type Zn‐ion batteries are discussed. Subsequently, the design principles and recent advances of cathode, anode, and electrolyte for “rocking‐chair” Zn‐ion batteries are summarized. To conclude, perspectives on the future of “rocking‐chair” Zn‐ion batteries are presented. It is hoped that this review may provide alternative directions for the design of Zn‐ion batteries.
ABCA7 and the altered lipidostasis hypothesis of Alzheimer's disease
Authors: Lyssenko Nicholas N. , Praticò Domenico 
Published: December 2020

AbstractWe propose the altered lipidostasis hypothesis of Alzheimer's disease (AD). It holds that vulnerable neurons of the entorhinal region generate a neurodegenerative lipid during normal function, adenosine triphosphate–binding cassette transporter subfamily A member 7 (ABCA7) protects from AD pathogenesis by removing it out of the cell, generation of the lipid increases with age, and the minimal amount of ABCA7 needed to dispose of the rising volumes of the lipid also increases with age. A survey of ABCA7 protein levels in the hippocampus or parietal cortex of 123 individuals with or without AD neuropathology showed that individuals with low ABCA7 developed AD neuropathology at a younger age, those with intermediate ABCA7 developed it later, and individuals who developed it very late had high ABCA7, the same as the youngest controls. ABC transporters closely similar to ABCA7 protect cells by removing toxic lipids. ABCA7 may have analogous functions. The hypothesis predicts lipidosis and membrane protein dysfunction in neurons with low ABCA7. Further work will identify the neurodegenerative lipid and determine approaches to exploit ABCA7 for therapeutic purposes.
Adaptive and Maladaptive Bodily Awareness: Distinguishing Interoceptive Sensibility and Interoceptive Attention from Anxiety‐Induced Somatization in Autism and Alexithymia
Authors: Trevisan Dominic A. , Mehling Wolf E. , McPartland James C. 
Published: December 2020

There is growing interest in “interoception” (i.e., detection and interpretation of internal body signals) as a relevant mechanism contributing to certain symptoms and features of autism spectrum disorder (ASD) and alexithymia. However, inconsistent measurement and operationalization of interoception has led to confusion and inconsistent findings in the literature. In this commentary, we present alternative interpretations of findings from existing studies to demonstrate that ASD and alexithymia are conditions associated with reduced adaptive forms of interoceptive attention (i.e., attention toward bodily signals) but heightened maladaptive forms of interoceptive attention related to anxiety‐induced somatization. Differentiating adaptive and maladaptive forms of interoceptive attention reveals a clearer pattern of findings in the research literature for further investigation of interoceptive processes that are involved in the neurobiology of ASD. However, interoception is a complex and multi‐faceted construct that requires continual refinement in conceptualization and operationalization. Interoception research may benefit from self‐report measures that clearly differentiate adaptive and maladaptive forms of bodily awareness.Lay SummarySome research suggests that autistic people have difficulty understanding bodily feelings such as hunger, illness, or emotions, whereas some studies have reported the opposite pattern of findings. We argue that this latter subset of studies reached false conclusions from using measures of bodily awareness that largely measure physical symptoms of anxiety. While attention to unpleasant bodily signals is an important ability necessary for maintaining healthy bodily functioning, excessive attention, and worry toward bodily signals can increase anxiety and be harmful.
Green and sustainable route for oxidative depolymerization of lignin: New platform for fine chemicals and fuels
Authors: Kumaravel Sangeetha , Thiruvengetam Prabaharan , Karthick Kannimuthu , Sankar Selvasundarasekar Sam , Karmakar Arun , Kundu Subrata 
Published: December 2020

AbstractDepolymerization of lignin biomass to its value‐added chemicals and fuels is pivotal for achieving the goals for sustainable society, and therefore has acquired key interest among the researchers worldwide. A number of distinct approaches have evolved in literature for the deconstruction of lignin framework to its mixture of complex constituents in recent decades. Among the existing practices, special attention has been devoted for robust site selective chemical transformation in the complex structural frameworks of lignin. Despite the initial challenges over a period of time, oxidation and oxidative cleavage process of aromatic building blocks of lignin biomass toward the fine chemical synthesis and fuel generation has improved substantially. The development has improved in terms of cost effectiveness, milder reaction conditions, and purity of compound individuals. These aforementioned oxidative protocols mainly involve the breaking of C‐C and C‐O bonds of complex lignin frameworks. More precisely in the line with environmentally friendly greener approach, the catalytic oxidation/oxidative cleavage reactions have received wide spread interest for their mild and selective nature toward the lignin depolymerization. This mini‐review aims to provide an overview of recent developments in the field of oxidative depolymerization of lignin under greener and environmentally benign conditions. Also, these oxidation protocols have been discussed in terms of scalability and recyclability as catalysts for different fields of applications.