bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low convergent validity of [11C]raclopride binding in extrastriatal brain regions: a PET study of within-subject correlations with [11C]FLB 457
Authors: Freiburghaus Tove , Svensson Jonas E. , Matheson Granville J. , Plavén-Sigray Pontus , Lundberg Johan , Farde Lars , Cervenka Simon 
Published: June 2020

AbstractDopamine D2 receptors (D2-R) in extrastriatal brain regions are of high interest for research in a wide range of psychiatric and neurologic disorders. Pharmacological competition studies and test-retest experiments have shown high validity and reliability of the positron emission tomography (PET) radioligand [11C]FLB 457 for D2-R quantification in extrastriatal brain regions. However, this radioligand is not available at most research centres. Instead, the medium affinity radioligand [11C]raclopride, which has been extensively validated for quantification of D2-R in the high-density region striatum, has been applied also in studies on extrastriatal D2-R. Recently, the validity of this approach has been questioned by observations of low occupancy of [11C]raclopride in extrastriatal regions in a pharmacological competition study. Here, we utilise a data set of 16 healthy control subjects examined with both [11C]raclopride and [11C]FLB 457 to assess the correlation in binding potential (BPND) in extrastriatal brain regions. BPND was quantified using the simplified reference tissue model with cerebellum as reference region. The rank order of mean regional BPND values were similar for both radioligands, and corresponded to previously reported data, both post-mortem and using PET. Nevertheless, weak to moderate within-subject correlations were observed between [11C]raclopride and [11C]FLB 457 BPNDextrastriatally (Pearson’s R: 0.30 - 0.56), in contrast to very strong correlations between repeated [11C]FLB 457 measurements (Pearson’s R: 0.82 - 0.98). These results are likely related to low signal to noise ratio of [11C]raclopride in extrastriatal brain regions, and further strengthen the recommendation that extrastriatal D2-R measures obtained with [11C]raclopride should be interpreted with caution.
A miR-124-mediated post-transcriptional mechanism controlling the cell fate switch of astrocytes to induced-neurons
Authors: Papadimitriou Elsa , Koutsoudaki Paraskevi N. , Thanou Irini , Karamitros Timokratis , Karagkouni Dimitra , Chroni-Tzartou Dafni , Gaitanou Maria , Gkemisis Christos , Margariti Maria , Xingi Evangelia , Tzartos Socrates J. , Hatzigeorgiou Artemis G. , Thomaidou Dimitra 
Published: June 2020

AbstractThe miRNA miR-124 has been employed supplementary to neurogenic TFs and other miRNAs to enhance direct neurogenic conversion by suppressing multiple non-neuronal targets. Aim of the study was to investigate whether miR-124 is sufficient to drive direct reprogramming of astrocytes to induced-neurons (iNs) on its own and elucidate its independent mechanism of reprogramming action. Our data show that miR-124 is a potent driver of the reprogramming switch of astrocytes towards an immature neuronal fate, by directly targeting the RNA-binding protein Zfp36l1 implicated in ARE-mediated mRNA decay and subsequently de-repressing Zfp36l1 neurogenic interactome. To this end miR-124 contribution in iNs’ production largely recapitulates endogenous neurogenesis pathways, being further enhanced upon addition of the neurogenic compound ISX9, which greatly improves both miR-124-induced reprogramming efficiency and iNs’ functional maturation. Importantly, miR-124 is potent to guide direct conversion of reactive astrocytes to immature iNs of cortical identityin vivofollowing cortical trauma, confirming its ‘master’ reprogramming capacity within the injured cortical microenvironment, while ISX9 supplementation confers a survival advantage to newly produced iNs.
Design of H_/H∞ fault detection observer for closed-loop nonlinear system with disturbance
Authors: Chen Zhengquan , Han Lu , Hou Yandong 
Published: June 2020

Purpose
This paper proposes a novel method of fault detection, which is based on H_/H∞ Runge–Kutta observer and an adaptive threshold for a class of closed-loop non-linear systems. The purpose of this paper is to improve the rapidity and accuracy of fault detection.

Design/methodology/approach
First, the authors design the H_/H∞ Runge–Kutta fault detection observer, which is used as a residual generator to decouple the residual from the input. The H_ performance index metric in the specified frequency domain is used to describe how sensitive the residual to the fault. The H∞ norm is used to describe the residual robustness to the external disturbance of the systems. The residual generator is designed to achieve the best tradeoff between robustness against unknown disturbances but sensitivity to faults, thus realizing the accurate detection of the fault by suppressing the influence of noise and disturbance on the residual. Next, the design of the H_/H∞ fault detection observer is transformed into a convex optimization problem and solved by linear matrix inequality. Then, a new adaptive threshold is designed to improve the accuracy of fault detection.

Findings
The effectiveness and correctness of the method are tested in simulation experiments.

Originality/value
This paper presents a novel approach to improve the accuracy and rapidity of fault detection for closed-loop non-linear system with disturbances and noise.
Gender of the family head and food insecurity in urban and rural Nigeria
Authors: Nwaka Ikechukwu Darlington , Akadiri Seyi Saint , Uma Kalu Ebi 
Published: June 2020

PurposeAre the urban and rural male-headed households (MHHs) or female-headed households (FHHs) poorer and food (in)secured? Such question is of very important policy concern in the drive towards achieving the first two of the Sustainable Development Goals.Design/methodology/approachThis paper uses 2010–2012 waves of General Household Survey cross-sectional panel data to investigate food (in)security and poverty dynamics amongst MHHs and FHHs in Nigeria, with particular attention to rural and urban dimensions.FindingsApplying the tobit and probit regressions while controlling for poverty and other household characteristics, we observed that female-headed families are more vulnerable to higher incidences of food insecurity than male-headed ones and with an overall significant urban food security advantage compared to rural areas. Comparing urban and rural results in terms of land access rights, urban food insecurity manifests more amongst urban FHHs non–Agri-land owners which however falls as food expenditure rises. However, the rise in per capita food consumption, agricultural characteristics and years of schooling reduces the likelihood of food insecurity for all households.Originality/valueThis study, therefore, offers relevant policy inputs towards addressing poverty and food insecurity in a typical developing country such as Nigeria.
A retrospective overview of the Asian Review of Accounting during 1992–2019
Authors: Kumar Satish , Sureka Riya , Pandey Nitesh 
Published: June 2020

PurposeAsian Review of Accounting (ARA), a leading journal in the field of accounting, completed its 29 years of active publishing in the year 2019. The primary objective of this study is to provide a comprehensive overview of the journal's publishing activities over these years.Design/methodology/approachThe authors use the bibliometric analysis and graphical visualization of bibliographic data to ascertain the publication pattern of ARA. Annual publication and citation structure, leading trends in authorship, institutional affiliation, country affiliation, most cited papers in ARA, documents most cited by ARA and frequency of keyword occurrence are also studied to provide a comprehensive overview of the journal between 1992 and 2019.FindingsMajor findings show that ARA has a progressive trend, in terms of both productivity and stature. The journal is highly influenced by Australia and Malaysia in respect of productivity. Major themes published include auditing, financial accounting, governmental and nonprofit accounting, corporate social responsibility, accounting education and financial reporting.Originality/valueThis study offers the first of its kind comprehensive summary of the research work published in ARA.
Corporate social responsibility and corporate citizenship in sustainable supply chain: a structured literature review
Authors: Akbari Mohammadreza , McClelland Robert 
Published: June 2020

PurposeThe purpose of this research is to provide a systematic insight into corporate social responsibility (CSR) and corporate citizenship (CC) in supply chain development, by analyzing the current literature, contemporary concepts, data and gaps for future discipline research.Design/methodology/approachThis research identifies information from existing academic journals and investigates research designs and methods, data analysis techniques, industry involvement and geographic locations. Information regarding university affiliation, publishers, authors, year of publication is also documented. A collection of online databases from 2001 to 2018 were explored, using the keywords “corporate social responsibility”, “corporate citizenship” and “supply chain” in their title and abstract, to deliver an inclusive listing of journal articles in this discipline area. Based on this approach, a total of 164 articles were found, and information on a chain of variables was collected.FindingsThere has been visible growth in published articles over the last 18 years regarding supply chain sustainability, CSR and CC. Analysis of the data collected shows that only five literature reviews have been published in this area. Further, key findings include 41% of publications were narrowly focused on four sectors of industry, leaving gaps in the research. 85% centered on the survey and conceptual model, leaving an additional gap for future research. Finally, developing and developed nation status should be delineated, researched and analyzed based on further segmentation of the industry by region.Research limitations/implicationsThis research is limited to reviewing only academic and professional articles available from Emerald, Elsevier, Wiley, Sage, Taylor and Francis, Springer, Scopus, JSTOR and EBSCO containing the words “corporate social responsibility”, “corporate citizenship” and “supply chain” in the title and abstract.Originality/valueThis assessment provides an enhanced appreciation of the current practices of current research and offers further directions within the CSR and CC in supply chain sustainable development.
Transient quasi-3D magneto-thermal analytical solution in PM induction heating device
Authors: Abdi Ammar , Ouazir Youcef , Barakat Georges , Amara Yacine 
Published: June 2020

Purpose
This paper aims to develop a new quasi-three dimensional (3D) analytical model devoted to the study of nonlinear transient magneto-thermal coupled problems in permanent magnet (PM) transverse flux induction heating device (TFIHD).

Design/methodology/approach
The presented work is based on analytical development of strongly coupled problem, including electromagnetic and thermal boundary problems. The electromagnetic problem is first solved by using the separation variables method to evaluate the induced currents in the nonmagnetic plate and the resulting power density loss distribution. The plate temperature profile is then obtained thanks to strong involvement of this magnetic model in a new analytical thermal model combining the separation of variables method and the Green’s functions transient regime analysis method. The coupled model is then used in a simulation procedure of the magneto-thermal process allowing taking into account the workpiece electrothermal nonlinear properties. The developed coupled model is validated by computing the performances of the studied PM TFIHD and comparing them to those obtained by finite element simulations.

Finding
An efficient transient quasi-3D magneto-thermal analytical model is developed allowing rapid analysis of PM induction heating for core heating of parallelepiped parts. The developed model also allows fast and accurate simulations of nonlinear and transient three dimensional (3D) magneto-thermal phenomena for planar induction heaters.

Research limitations implications
The developed quasi-3D magneto-thermal analytical model is limited to design induction heating devices of planar structure with PM inductors.

Originality/value
A new transient quasi-3D magneto-thermal analytical model accounts for non-linearity and edge effect and helps to fast study and fast design of linear permanent magnet induction heating device.
“You can't be an atheist here”: Christianity and Outward Bound in Britain, c.1941–1965
Authors: Freeman Mark 
Published: June 2020

PurposeThe purpose of this study is to explore the role of formal religion in the early years of Outward Bound, a significant outdoor education organisation in Britain, from the 1940s to the 1960s.Design/methodology/approachThis article is based on archival and other documentary research in various archives and libraries, mostly in the United Kingdom.FindingsThe article shows that religious “instruction” was a central feature of the outdoor education that Outward Bound provided. The nature and extent of this aspect of the training was a matter of considerable debate within the Outward Bound Trust and was influenced by older traditions of muscular Christianity as well as the specific context of the early post–Second World War period. However, the religious influences at the schools were marginalised by the 1960s; although formal Christian observances did not disappear, the emphasis shifted to the promotion of a vaguer spirituality associated with the idea that “the mountains speak for themselves”.Originality/valueThe article establishes the importance of organised Christianity and formal religious observances in the early years of Outward Bound, a feature which has generally been overlooked in the historical literature. It contributes to wider analyses of outdoor education, religious education and secularisation in the mid-twentieth century.
Comparing the impact of three different experiential approaches to entrepreneurship in education
Authors: Lackéus Martin 
Published: June 2020

PurposeThree different pedagogical approaches grounded in three different definitional foundations of entrepreneurship have been compared in relation to their effects on students. They are: (1) “Idea and Artefact-Creation Pedagogy” (IACP), grounded in opportunity identification and creation, (2) “Value-Creation Pedagogy” (VaCP), grounded in value creation and (3) “Venture-Creation Pedagogy” (VeCP), grounded in organisation creation.Design/methodology/approachData were collected at 35 different sites where education was deemed to be entrepreneurial and experiential. A quantitative, smartphone app-based data collection method was used alongside a qualitative interview approach. 10,953 short-survey responses were received from 1,048 participants. Responses were used to inform respondent selection and discussion topics, in 291 student and teacher interviews. Comparative analysis was then conducted.FindingsThe three approaches resulted in very different outcomes, both in magnitude and in kind. VaCP had strong effects on entrepreneurial competencies, on student motivation and on knowledge and skills acquisition. VeCP had weaker effects on knowledge and skills acquisition. IACP had weak effects on all outcomes probed for. Differences were attributed to variation in prevalence of certain emotional learning events and to variation in purpose as perceived by students.Research limitations/implicationsVaCP could serve as an escape from the potential dilemma faced by many teachers in entrepreneurial education, of being caught between two limiting courses of action; a marginal VeCP approach and a fuzzy IACP one. This could prompt policymakers to reconsider established policies. However, further research in other contexts is needed, to corroborate the extent of differences between these three approaches.Originality/valueMost impact studies in experiential entrepreneurial education focus only on organisation-creation-based education. This study contributes by investigating entrepreneurial education that is also grounded in two other definitional foundations. Allowance has been made for novel comparative conclusions.
Scoping the application of primary care advanced clinical practice roles in England
Authors: Thompson Juliana , Tiplady Sue , Hodgson Phil , Proud Carole 
Published: June 2020

PurposeThis study aims to scope the profile and application of an advanced clinical practitioner (ACP) roles in primary care in the North of England and how these roles meet the requirements of Health Education England's (HEE’s) ACP workforce capability framework.Design/methodology/approachA two-stage design was used. Stage 1 analysed health and social care workforce intelligence reports to inform scoping of numbers of ACPs working in primary care. Stage 2 used two surveys. Survey 1 targeted ACP leads and collected strategic-level data about ACP application. Survey 2 targeted staff who perceived themselves to be working as ACPs. Survey 2 was in three parts. Part 1 collected demographic data. Part 2 required participants to record their perceived competence against each of the HEE ACP framework capability criteria. Part 3 required respondents to identify facilitators and barriers to ACP practice.FindingsDespite the introduction of HEE's ACP capability framework, there is inconsistency and confusion about the ACP role. The results indicated a need for standardisation of role definition and educational and practice requirements. The results also suggested that some ACPs are not working to their full potential, while some staff who are employed as “gap-fillers” to provide routine clinical services perceive themselves as ACPs despite not working at the ACP level.Originality/valueAlthough previous research has explored the application of ACP practice in primary care, few studies have considered ACP application in the light of the introduction of workforce capability frameworks aimed at standardising ACP practice.
The case for blockchain in IoT identity management
Authors: Sousa Patrícia R. , Resende João S. , Martins Rolando , Antunes Luís 
Published: June 2020

PurposeThe aim of this paper is to evaluate the use of blockchain for identity management (IdM) in the context of the Internet of things (IoT) while focusing on privacy-preserving approaches and its applications to healthcare scenarios.Design/methodology/approachThe paper describes the most relevant IdM systems focusing on privacy preserving with or without blockchain and evaluates them against ten selected features grouped into three categories: privacy, usability and IoT. Then, it is important to analyze whether blockchain should be used in all scenarios, according to the importance of each feature for different use cases.FindingsBased on analysis of existing systems, Sovrin is the IdM system that covers more features and is based on blockchain. For each of the evaluated use cases, Sovrin and UniquID were the chosen systems.Research limitations/implicationsThis paper opens new lines of research for IdM systems in IoT, including challenges related to device identity definition, privacy preserving and new security mechanisms.Originality/valueThis paper contributes to the ongoing research in IdM systems for IoT. The adequacy of blockchain is not only analyzed considering the technology; instead the authors analyze its application to real environments considering the required features for each use case.
The big data-business strategy interconnection: a grand challenge for knowledge management. A review and future perspectives
Authors: Ciampi Francesco , Marzi Giacomo , Demi Stefano , Faraoni Monica 
Published: June 2020

Purpose
Designing knowledge management (KM) systems capable of transforming big data into information characterised by strategic value is a major challenge faced nowadays by firms in almost all industries. However, in the managerial field, big data is now mainly used to support operational activities while its strategic potential is still largely unexploited. Based on these considerations, this study proposes an overview of the literature regarding the relationship between big data and business strategy.

Design/methodology/approach
A bibliographic coupling method is applied over a dataset of 128 peer-reviewed articles, published from 2013 (first year when articles regarding the big data-business strategy relationship were published) to 2019. Thereafter, a systematic literature review is presented on 116 papers, which were found to be interconnected based on the VOSviewer algorithm.

Findings
This study discovers the existence of four thematic clusters. Three of the clusters relate to the following topics: big data and supply chain strategy; big data, personalisation and co-creation strategies and big data, strategic planning and strategic value creation. The fourth cluster concerns the relationship between big data and KM and represents a ‘bridge’ between the other three clusters.

Research limitations/implications
Based on the bibliometric analysis and the systematic literature review, this study identifies relevant understudied topics and research gaps, which are suggested as future research directions.

Originality/value
This is the first study to systematise and discuss the literature concerning the relationship between big data and firm strategy.
Grey shade of work environment triad – effect of supervisor ostracism and perceived organizational obstruction on employees' behaviour: a moderated-mediation model
Authors: Akhtar Muhammad Waheed , Syed Fauzia , Javed Muzhar , Husnain Mudassir 
Published: June 2020

PurposeThis study, based on the moderated-mediation model, investigates the indirect effect of facades of conformity in the relationship between supervisor ostracism and unethical work behaviour. Furthermore, this study tested the moderating role of perceived organizational obstruction in the aforementioned relationship through facades of conformity.Design/methodology/approachEmploying a multi-wave and two-source data from employees and peers (n = 264) of the services sector in Pakistan, the authors tested the proposed framework using Hayes and Preacher moderated-mediation technique.FindingsThe findings reflect that supervisor ostracism encourages unethical behaviour at the workplace. Further, results revealed that facades of conformity mediated this direct relationship. Moreover, the authors found that perceived organizational obstruction moderated the relationship between supervisor ostracism and facades of conformity. Results also confirm that perceived organizational obstruction moderates the mediated relationship.Research limitations/implicationsThe paper concludes with a discussion, managerial implications, limitations and directions for future research.Originality/valueThis study added value in the literature of supervisor ostracism, facades of conformity, unethical work behaviour and perceived organizational obstruction.