bluuebunny/crossref_metadata_2025_split huggingface dataset:
Living beyond cancer: Adolescent and young adult perspectives on choice of and participation in meaningful occupational roles
Authors: Wallis Amy , Meredith Pamela , Stanley Mandy 
Published: October 2020

Introduction Whilst it is recognised that cancer may present numerous challenges for the adolescent or young adult during treatment, experiences after this stage as the young person transitions to life without cancer have received little attention. The purpose of this study is to understand the implications of having survived cancer for the young person’s choice of, and participation in, meaningful occupational roles. Method In this qualitative descriptive study, four participants were interviewed on two occasions using semi-structured interviews, with the subsequent interview supplemented with photo elicitation. Participants were male and female, aged 19 and 24 years, and medically cleared of (living beyond) cancer. Thematic analysis was used. Results Three main themes emerged: changes in relationships; moving beyond; and future perspectives. Adolescents and young adults identified the impact of the cancer experience on interpersonal relationships and related occupational roles (for example parenthood), and described how cancer affected their participation in, and the meaning of, occupational roles, and altered present and future occupational priorities. Conclusion Having cancer as an adolescent or young adult has lasting impacts on occupational roles. Understanding the opportunities and challenges this population may face when living beyond cancer can assist in providing enhanced age-aware occupational therapy, potentially optimising outcomes for young people.
Conspiracy theories and UFOs
Authors: Karbovnik Damien 
Published: October 2020

AbstractEver since UFOs were first spotted in the sky in 1947, many theories have sought to explain these apparitions that defy science. Some of them lend weight to conspiracy theories. Even though there is a wide spectrum of conspiracies involving a certain amount of people and organizations, the purpose of this article will be to follow one particular author's point of view, Jimmy Guieu's, namely because of the global approach that he favors. Guieu, a pioneer of ufology, followed its evolution up until his death in 2000 and tried, through his many works, to offer some enlightening information on UFOs. Ranging from Black-out to the secret government embodied by the MJ-12, he patiently assembled the pieces of a puzzle whose final product takes the form of “romans-vérité”. Although he remains a rather marginal author, some approaches similar to Jimmy Guieu's can be seen on television in widely distributed productions; this will allow us to put forward the existence of a recurrent narrative structure in the alien conspiracy theory.
Single‐day and cumulative effects of ambient particulate matter exposure on emergency department visits for respiratory disease in South Korea
Authors: Kim Hakjung , Yu Woosung 
Published: October 2020

Background:Along with the industrialization, the air pollutants have gained more attention and studies especially about respiratory diseases were conducted. Emergency visit reflects acute aggravation of disease rather than chronic exacerbation.Objectives:The objective of this study was to evaluate the relationship between the ambient particulate matter and the emergency visits with respiratory disease in South Korea.Methods:Patients diagnosed with respiratory disease in the emergency department in 2018 were enrolled. The data of meteorological factors and air pollutants between 4 December 2017 and 31 December 2018 were acquired. Poisson regression was used with daily emergency visits as the response variable and single‐day particulate matter concentration as the explanatory variable.Results:A total of 4207 patients were enrolled. In Poisson regression analysis of all respiratory diseases, the effects of and were strongest at day before 8 and 26. Age older than 65 group and chronic respiratory disease group had earlier lag effect than the all‐diseases group. Cumulative effect was peaked at 14 lag day. The split point of prediction was 87 µg/m3 before 3 days for and 37 µg/m3 before 8 days for .Conclusion:The results can be used to predict the increase of emergency visits and need for medical resources when the ambient particulate matter concentration rises.
Robust control of active magnetic bearing systems with an add-on controller to cancel gyroscopic effects: Is it worth it?
Authors: Sahinkaya Alican , Sawicki Jerzy T 
Published: October 2020

One of the performance-limiting factors in the design of robust controllers for active magnetic bearing systems is the fact that the controller needs to be robust to the gyroscopic effects, that is rotational speed-dependent dynamics of the system. Studies in the literature show that better performance and stability can be achieved when gyroscopic effects are explicitly handled by a cross-feedback control for rigid rotor-active magnetic bearing systems. For flexible rotor-active magnetic bearing systems, gyroscopic effects are mainly dealt by defining the rotational speed as an uncertain parameter of the model or with linear parameter-varying controllers. This study explores the novel idea of compensating gyroscopic effects of a flexible rotor-active magnetic bearing system with an add-on controller and investigates its effects on the achieved performance of μ-controllers. The study is carried out on an experimental active magnetic bearing test rig with relatively high gyroscopic effects. An add-on controller is designed to compensate the gyroscopic effects of the first and second flexible modes of the rotor. Two μ-controllers are designed for the system: (1) benchmark controller that is designed using a standard control approach for active magnetic bearing systems and (2) controller designed with a modified model of the system in which the gyroscopic effects for the first and second flexible modes are reduced because of the presence of the add-on controller. Both controllers are implemented, and their performances are compared for initial levitation, run-up test from 0 to 10,000 r/min, orbit sizes at various speeds, and the computational cost of implementing each controller. The results suggest that better performance is potentially possible at the cost of significant increase in the computational complexity of the controller.
Evaluation of clinical examination location on stress in cats: a randomized crossover trial
Authors: Griffin Francesca C , Mandese Wendy W , Reynolds Penny S , Deriberprey Alexis S , Blew Alyssa C 
Published: October 2020

Objectives The objective of this study was to quantify the effects of owner separation and physical examination location on fear, anxiety and stress (FAS) behavioral indicators in cats. Methods The study was a prospective, non-blinded, randomized, two-period, two-treatment crossover trial. Healthy adult cats presenting for wellness or dental evaluations at a single veterinary teaching hospital received three physical examinations: a baseline assessment (owner present) followed by physical examinations in both a treatment area (owner absent [TAOA]) and an examination room (owner present [EROP]). The physical examination sequence order was randomized. Low-stress handling techniques were used for all examinations. The primary endpoints were heart rate (HR; beats per min [bpm]) and total FAS scores. HR was measured by auscultation, and FAS by five specific behaviors scored as 0/1 and summed for each assessment period. Results Twenty-one healthy cats were enrolled. HR measured at entry (baseline) was a significant determinant of subsequent HR readings. HR measured during examinations conducted in both EROP and TAOA were elevated to levels indicative of stress (>180 bpm). HR was significantly higher for TAOA relative to EROP (30 bpm, 95% confidence interval 18–43; P <0.001). Behavioral FAS scores showed no statistically significant effects of sequence or room. FAS scores for TAOA assessments were clinically elevated relative to baseline (1.5 FAS, SE 0.7; P = 0.05); EROP FAS scores relative to baseline did not differ statistically (0.5 units, SE = 0.5; P = 0.43). Conclusions and relevance Owner separation coupled with physical examination location can result in clinically significant increases in perceived stress in cats, and compromise vital sign assessments. Whenever possible, physical examinations and procedures should take place with the owner present with separation from unfamiliar dogs and cats.
The Association Between Dietary Habits and Other Lifestyle Indicators and Dysglycemia in Saudi Adults Free of Previous Diagnosis of Diabetes
Authors: Jambi Hanan , Enani Sumia , Malibary Manal , Bahijri Suhad , Eldakhakhny Basmah , Al-Ahmadi Jawaher , Al Raddadi Rajaa , Ajabnoor Ghada , Boraie Anwar , Tuomilehto Jaakko 
Published: October 2020

Objective: Study the association of dietary habits and other indicators of lifestyle with dysglycemia in Saudi adults. Methods: In a cross-sectional design, data were obtained from 1403 Saudi adults (⩾20 years), not previously diagnosed with diabetes. Demographics, lifestyle variables and dietary habits were obtained using a predesigned questionnaire. Fasting plasma glucose, glycated hemoglobin and 1-hour oral glucose tolerance test were used to identify dysglycemia. Regression analysis was performed to determine the associations of dietary factors and other indicators of lifestyle with dysglycemia. Results: A total 1075 adults (596 men, and 479 women) had normoglycemia, and 328 (195 men, and 133 women) had dysglycemia. Following adjustment for age, BMI and waist circumference, in men the weekly intake of 5 portions or more of red meat and Turkish coffee were associated with decreased odds of having dysglycemia odds ratio (OR) 0.444 (95% CI: 0.223, 0.881; P = .02) and 0.387 (95% CI: 0.202, 0.74; P = .004), respectively. In women, the intake of fresh juice 1 to 4 portions per week and 5 portions or more were associated with OR 0.603 (95% CI: 0.369, 0.985; P = .043) and OR 0.511 (95% CI: 0.279, 0.935; P = .029) decreased odds of having dysglycemia, respectively compared with women who did not drink fresh juice. The intake of 5 times or more per week of hibiscus drink was associated with increased odds of having dysglycemia, OR 5.551 (95% CI: 1.576, 19.55, P = .008) compared with women not using such a drink. Other lifestyle factors were not associated with dysglycemia. Conclusion: Dietary practices by studied Saudis have some impact on risk of dysglycemia, with obvious sex differences.
Optical coherence tomography outcomes from SPRINT-MS, a multicenter, randomized, double-blind trial of ibudilast in progressive multiple sclerosis
Authors: Bermel Robert A , Fedler Janel K , Kaiser Peter , Novalis Cindy , Schneebaum Jeff , Klingner Elizabeth A , Williams Dawn , Yankey Jon W , Ecklund Dixie J , Chase Marianne , Naismith Robert T , Klawiter Eric C , Goodman Andrew D , Coffey Christopher S , Fox Robert J 
Published: October 2020

Background: The SPRINT-MS trial demonstrated benefit of ibudilast on brain atrophy over 96 weeks in progressive multiple sclerosis (MS). Optical coherence tomography (OCT) was performed in all trial participants. Objective: Report the OCT results of the SPRINT-MS trial. Methods: OCT was obtained at baseline and every 6 months using spectral domain OCT and analyzed by an OCT reading center. Change in each OCT outcome measure by treatment group was estimated using linear mixed models. Results: Change in pRNFL thickness was +0.0424 uM/year (95% confidence interval (CI): −0.3091 to 0.3939) for ibudilast versus −0.2630 uM (95% CI: −0.5973 to 0.0714) for placebo ( n = 244, p = 0.22). Macular volume change was −0.00503 mm3/year (−0.02693 to 0.01688) with ibudilast versus −0.03659 mm3/year (−0.05824 to −0.01494) for placebo in the Spectralis cohort ( n = 61, p = 0.044). For the Cirrus cohort, macular volume change was −0.00040 mm3/year (−0.02167, 0.020866) with ibudilast compared to −0.02083 mm3/year (−0.04134 to −0.00033) for placebo ( n = 183, p = 0.1734). Ganglion cell-inner plexiform layer thickness change, available from Cirrus, was −0.4893 uM/year (−0.9132, −0.0654) with ibudilast versus −0.9587 uM/year (−1.3677, −0.5498) with placebo ( n = 183, p = 0.12). Conclusion: Retinal thinning in MS may be attenuated by ibudilast. Sample size estimates suggest OCT can be a viable outcome measure in progressive MS trials if a therapy has a large treatment effect. Trial registration: NN102/SPRINT-MS ClinicalTrials.gov number, NCT01982942.
A Novel Scoring System for Small Artery Disease and Medial Arterial Calcification Is Strongly Associated With Major Adverse Limb Events in Patients With Chronic Limb-Threatening Ischemia
Authors: Ferraresi Roberto , Ucci Alessandro , Pizzuto Alessandra , Losurdo Fabrizio , Caminiti Maurizio , Minnella Daniela , Casini Andrea , Clerici Giacomo , Montero-Baker Miguel , Mills Joseph 
Published: October 2020

Purpose: To evaluate the roles of small artery disease (SAD) and medial arterial calcification (MAC) in patients with chronic limb-threatening ischemia (CLTI) and to identify any correlation between these factors and peripheral artery disease (PAD) or outcomes after treatment. Materials and Methods: A retrospective review was conducted of 259 limbs with tissue loss among 223 CLTI patients (mean age 72.2±11.4 years; 194 men) having an angiographic foot vessel study, foot radiography, and at least 6 months of follow-up after intervention. SAD and MAC were quantified using a 3-level score (0=absent, 1=moderate, 2=severe) based on angiography for SAD and foot radiographs for MAC. The MAC score was validated and compared with the SAD score, evaluating their associations with PAD distribution and clinical outcomes. Results: Based on the MAC score, the 259 limbs were classified as 55 group 0 (21.2%), 89 group 1 (34.4%), and 115 group 2 (44.4%). The SAD score stratified the 259 limbs as 67 group 0 (25.9%), 76 group 1 (29.3%), and 116 group 2 (44.8%). Interobserver reproducibility of the MAC score was high (correlation coefficient 0.96). Sensitivity and specificity of the MAC score in detecting SAD was 100% and 98.1%, respectively, in SAD groups 0 and 2 vs 99.1% and 92.7%, respectively, for SAD group 1. PAD was more proximal in MAC and SAD groups 0 and more distal in groups 1 and 2. Both MAC and SAD scores were able to predict clinical endpoints. Multivariable analysis demonstrated that the MAC score represents an independent risk factor for adverse limb events. Conclusion: SAD and MAC must be considered expressions of the same obstructing disease, able to adversely impact the fate of CLTI patients. SAD and MAC scores are powerful prognostic indicators of major adverse limb events in CLTI patients.
Construction and Validation of Nomograms for Predicting the Prognosis of Juvenile Osteosarcoma: A Real-World Analysis in the SEER Database
Authors: Jiang Yao , Wang Tianyu , Wei Zizheng 
Published: October 2020

Background: Osteosarcoma is one of the most common malignant bone tumors, with a high incidence in adolescence. The objective of this study was to construct prognostic nomograms for predicting the prognosis of juvenile osteosarcoma. Methods: Patients with osteosarcoma diagnosed between 2004 and 2015 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. The essential clinical predictors were identified with univariate and multivariate Cox analysis. Nomograms were constructed to predict the 3- and 5-year cancer- specific survival (CSS) and overall survival (OS). Concordance index (C-index) and calibration plots were performed to validate the predictive performance of nomograms. Results: We enrolled 736 adolescents with osteosarcoma from the SEER database, with 516 samples grouped into a training cohort and 220 samples grouped into a validation cohort. In multivariate analysis of the training cohort, predictors including tumor size, surgery treatment and AJCC stage were found to be associated with OS and CSS, while age was only associated with CSS. Construction of nomograms based on these predictors was performed to evaluate the prognosis of adolescents with osteosarcoma. The C-index and calibration curves also showed the satisfactory performance of these nomograms for prognosis prediction. Conclusion: The developed nomograms are useful tools for precisely predicting the prognosis of adolescents with osteosarcoma, which could enable patients to be more accurately managed in clinical practice.
Clinical outcomes from profundoplasty performed as a sole procedure for revascularization in critically ischaemic limbs
Authors: Elsharkawi Mohamed , Elkassaby Mohammed , McVeigh Niall , Dowdall Joseph , Barry Mary , Sheehan Stephen 
Published: October 2020

Objectives The aim of this study is to investigate the durability and clinical efficacy of profundoplasty as a sole procedure in patients presenting with critical limb ischaemia associated with profunda femoral artery disease and superficial femoral artery occlusion. Methods Retrospective analysis of outcomes from all patients who underwent surgical profundoplasty in a single tertiary referral centre was performed. Patients who presented with either rest pain or tissue loss and had combined profunda femoral artery disease and superficial femoral artery occlusion were included in the study. Outcomes were compared between the rest pain and the tissue loss groups. Results Between 2009 and 2019, 51 procedures were performed in 49 patients; 27 (53%) procedures were performed for rest pain and 24 (47%) for tissue loss. Technical success was 100% in both groups. Procedure success was significantly better in the rest pain group owing to lower procedure-related complications ( p = 0.037). Incidence of major adverse cardiovascular events was higher in the tissue loss group with five reported cases compared to only one in the rest pain group ( p = .05); 85.2% of patients with rest pain experienced clinical improvement compared to only 33.3% in the tissue loss group ( p < .001). Higher rates of re-intervention were recorded in the tissue loss group, but this was not statistically significant. Amputation-free survival at 3, 6 and 12 months was 96%, 96% and 92% in the rest pain group, respectively, compared to 77%, 67% and 54% in the tissue loss group ( p = .004). At one-year, freedom from major adverse limb events was lower in patients with tissue loss at 43% compared to 81% in patients with rest pain ( p = .009). Conclusions Profundoplasty performed as a sole procedure for revascularisation of the critically ischaemic limb is a viable straightforward option. However, our results suggest that it may be more effective in the treatment of rest pain rather than in the setting of tissue loss when a combined superficial femoral artery angioplasty or distal bypass may be required.
Gout management and outcomes during the COVID-19 pandemic: a cross-sectional internet survey
Authors: Singh Jasvinder A. , Edwards N. Lawrence 
Published: October 2020

Aim: We aimed to assess the gout management during the COVID-19 pandemic. Methods: We assessed medication use, healthcare utilization, gout-specific health-related quality of life (HRQoL) on the Gout Impact Scale (GIS), psychological distress using the patient health questionnaire-4 (PHQ-4), and resilience in people with self-reported physician-diagnosed gout during the COVID-19 pandemic in a cross-sectional Internet survey. Results: Among the 122 survey respondents with physician-diagnosed gout, 82% were prescribed urate-lowering therapy (ULT) and 66% were taking ULT daily; mean age was 54.2 years [standard deviation (SD), 13.8], 65% were male, and 79% were White. More regular use of gout medication was reported during the COVID-19 pandemic: allopurinol, 44%; colchicine, 37%; non-steroidal anti-inflammatory drugs, 36%. Gout flares were common: 63% had ⩾1 gout flare monthly; 11% went to emergency room/urgent care; and 2% were hospitalized with gout flares. Between 41% and 56% of respondents reported more difficulty with gout management and related functional status related to COVID-19; 17–37% had difficulty with healthcare access for gout. HRQOL deficits were evident for gout concern overall, 79.4 (SD, 25); unmet gout treatment need, 64.5 (SD, 27.1); and gout concern during flare, 67.3 (SD, 27.1); but less so for gout medication side effects, 48.9 (SD, 27.4). Psychological distress was moderate in 19% and severe in 15% (mild, 22%; normal, 45%). Resilience score on Connor–Davidson Resilience Scale (CD-RISC2) was 5.6 (SD, 1.8; range 0–8). Compared with no/mild psychological distress, moderate–severe psychological distress during the COVID-19 pandemic was significantly associated with more difficulty getting gout medication filled ( p = 0.02), flares treated ( p = 0.005), and receiving gout education ( p = 0.001). Conclusion: Healthcare gaps, psychological distress, and HRQoL deficits were commonly reported by people with gout during the COVID-19 pandemic. Interventions to address these challenges for people with gout during the COVID-19 pandemic are needed.
Physiotherapy after tibial plateau fracture fixation: A systematic review of the literature
Authors: Iliopoulos Efthymios , Galanis Nikiforos 
Published: October 2020

Background: Tibial plateau fractures are frequent injuries that orthopaedic surgeons face. It has been reported that they have a significant negative impact on the patients’ lives, decreasing their quality of live, keeping them of work for long periods of time and reducing their activity levels. Aim: Interestingly, there is not enough focus in the literature about the post-operative rehabilitation of these patients. The aim of the present review is to investigate this field of the literature and try to give answers in four main questions: the range of motion exercises post-surgery, the immobilisation, the weight-bearing status and the ongoing rehabilitation. Materials and Methods: A literature search was conducted using the PubMed and the Google Scholar search engines. A total of 39 articles met the criteria to be included in the study. Results: The literature about this subject is scarce and controversial. Early range of motion exercises should be encouraged as soon as possible after the procedure. The immobilisation after plate fixation does not seem to be correlated with any benefits to the patients. The weight-bearing status of the patients was the most controversial in the literature with the early weight-bearing gaining ground at the most recent studies. Tibia plateau fractures can have significant impact on the patients’ lives, so ongoing rehabilitation with focus on quadriceps strengthening and proprioception exercises is recommended. Conclusion: The present literature review illuminates the controversy that exists in the literature about the physiotherapy following tibia plateau fracture fixation. Early range of motion exercises and early weight bearing should be encouraged. Immobilisation does not seem to provide any benefit. Ongoing rehabilitation should be considered with the view of better clinical outcomes.