bluuebunny/crossref_metadata_2025_split huggingface dataset:
AA genotype of PLIN1 13041A>G as an unfavourable predictive factor of malnutrition associated with fat mass loss in locally advanced head and neck cancer male patients treated with radiotherapy
Authors: Powrózek Tomasz , Brzozowska Anna , Mazurek Marcin , Prendecka Monika , Homa-Mlak Iwona , Mlak Radosław , Małecka-Massalska Teresa 
Published: August 2020

Abstract
Introduction
Malnutrition is a frequently diagnosed condition in head and neck cancer (HNC) patients after radiation therapy (RTH). Malnutrition causes adipose tissue dysfunction associated with intensified lipolysis and disruption of the activity of mechanisms that protect adipose tissue against this process, which include the protective function of perilipin.

Material and methods
The purpose of this study was the evaluation of the predictive value of 13041A>G PLIN1 polymorphism in the development of malnutrition related to adipose tissue loss in a group of 80 patients with locally advanced HNC treated by means of radical radiation therapy.

Results
After the completion of RTH, men with AA genotype had significantly lower fat mass (FM compared to men with G haplotype; FM: 13.84 ± 6.36 kg and 19.06 ± 6.30 kg (p = 0.009). In consequence of RTH, the AA genotype carriers lost an average of 37.01% adipose tissue mass and patients with GA and GG genotypes lost 12.82 and 0.31% (p = 0.035), respectively. AA genotype was also associated with higher chance of ≥ 10%, ≥ 20% and ≥ 30% FM loss in the course of RTH (OR = 13.78; 5.78; 2.28).

Conclusions
The evaluation of such molecular factors as SNP 13041A>G may have higher predictive value in the development of malnutrition associated with severe loss of fat mass than the subjective scales, e.g., SGA and NRS-2002. The presence of AA genotype on men with HNC before RTH may facilitate earlier nutritional intervention and supportive treatment aimed at limiting or preventing body mass and fat mass loss during the applied treatment.
Early unplanned readmission of neurosurgical patients after treatment of intracranial lesions: a comparison between surgical and non-surgical intervention group
Authors: Sander Caroline , Oppermann Henry , Nestler Ulf , Sander Katharina , von Dercks Nikolaus , Meixensberger Jürgen 
Published: August 2020

AbstractBackgroundRecent health care policy making has highlighted the necessity for understanding factors that influence readmission. To elucidate the rate, reason, and predictors of readmissions in neurosurgical patients, we analyzed unscheduled readmissions to our neurosurgical department after treatment for cranial or cerebral lesions.MethodsFrom 2015 to 2017, all adult patients who had been discharged from our Department of Neurosurgery and were readmitted within 30 days were included into the study cohort. The patients were divided into a surgical and a non-surgical group. The main outcome measure was unplanned inpatient admission within 30 days of discharge.ResultsDuring the observation period, 183 (7.4%) of 2486 patients had to be readmitted unexpectedly within 30 days after discharge. The main readmission causes were surgical site infection (34.4 %) and seizure (16.4%) in the surgical group, compared to natural progression of the original diagnosis (38.2%) in the non-surgical group. Most important predictors for an unplanned readmission were younger age, presence of malignoma (OR: 2.44), and presence of cardiovascular side diagnoses in the surgical group. In the non-surgical group, predictors were length of stay (OR: 1.07) and the need for intensive care (OR: 5.79).ConclusionsWe demonstrated that reasons for readmission vary between operated and non-operated patients and are preventable in large numbers. In addition, we identified treatment-related partly modifiable factors as predictors of unplanned readmission in the non-surgical group, while unmodifiable patient-related factors predominated in the surgical group. Further patient-related risk adjustment models are needed to establish an individualized preventive strategy in order to reduce unplanned readmissions.
Phase I/II study of erlotinib plus S-1 for patients with previously treated non-small cell lung cancer: Thoracic Oncology Research Group (TORG) 0808/0913
Authors: Nakahara Yoshiro , Shimokawa Tsuneo , Misumi Yuki , Nogami Naoyuki , Shinkai Tetsu , Seki Nobuhiko , Hosomi Yukio , Hida Naoya , Okamoto Hiroaki 
Published: August 2020

SummaryIntroduction In preclinical data, the combination therapy with S-1 and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) had a synergistic antitumor effect on non-small cell lung cancer (NSCLC), regardless of the EGFR mutation status. Patients and Methods Patients with previously treated NSCLC and adequate organ function regardless of EGFR mutation status were eligible for the phase I study, with wild-type EGFR were eligible for the phase II study. Treatment consisted of erlotinib 150 mg/body orally once every day and S-1 60 mg/m2, 70 mg/m2, or 80 mg/m2 (level 0, level 1, or level 2) orally on days 1–14 every three weeks. The primary endpoint for the phase I study was the determination of the recommended dose (RD), the phase II study was the overall response rate (ORR). Results A total of 7 patients with performance-status (PS) 0 or 1 were enrolled as subjects in phase I. Five of these subjects were EGFR-mutation positive. Four subjects were enrolled at S-1 dose level 1 and 3 were enrolled at S-1 dose level 2. No dose-limiting toxicities were observed in these subjects. The RD was decided as erlotinib 150 mg/body and S-1 80 mg/m2. In phase I, 5 subjects achieved partial response, and the ORR was 71.4%. A total of 10 patients with PS 0, 1, or 2 EGFR-wild type NSCLC were enrolled in phase II. In phase II, the ORR was 10.0%, and the disease control rate (DCR) was 40.0%. After the enrollment of 10 subjects, enrollment was stopped based on two treatment-related deaths. Conclusion The combination therapy of erlotinib plus S-1 was not feasible in the EGFR wild-type NSCLC at least and early stopped. Trial registration: UMIN-CTR Identifier: 000003421 (2010/03/31, phase I), 000003422 (2010/03/31, Phase II).
Multiple-group membership: warmth and competence perceptions in the workplace
Authors: Strinić Andrea , Carlsson Magnus , Agerström Jens 
Published: August 2020

AbstractWhat kinds of stereotypes are evoked when employers review a job application from a 55-year-old Arab woman? Most previous research on stereotypes has focused on single demographic group categories (e.g., race or gender) rather than on their combinations, even though people inevitably belong to multiple group categories simultaneously. The current study examines how different combinations of demographic group categories (ethnicity, gender, sexual orientation, and age) are perceived in the context of the workplace, with a focus on two fundamental dimensions of social perception: warmth and competence. The results reveal interesting interactions among the studied demographic group categories such that when stigmatized group categories are added to one another, it does not necessarily produce additive negative effects on warmth and competence perceptions. Rather, one category that is perceived negatively in isolation (e.g., homosexuality) can offset the negative impact of another stigmatized category (e.g., Arab ethnicity). Practical implications for stereotyping and discrimination in the workplace are discussed.
The Italian Registry for Primary Immunodeficiencies (Italian Primary Immunodeficiency Network; IPINet): Twenty Years of Experience (1999–2019)
Authors: Lougaris Vassilios , Pession Andrea , Baronio Manuela , Soresina Annarosa , Rondelli Roberto , Gazzurelli Luisa , Benvenuto Alessio , Martino Silvana , Gattorno Marco , Biondi Andrea , Zecca Marco , Marinoni Maddalena , Fabio Giovanna , Aiuti Alessandro , Marseglia Gianluigi , Putti Maria Caterina , Agostini Carlo , Lunardi Claudio , Tommasini Alberto , Bertolini Patrizia , Gambineri Eleonora , Consolini Rita , Matucci Andrea , Azzari Chiara , Danieli Maria Giovanna , Paganelli Roberto , Duse Marzia , Cancrini Caterina , Moschese Viviana , Chessa Luciana , Spadaro Giuseppe , Civino Adele , Vacca Angelo , Cardinale Fabio , Martire Baldassare , Carpino Luigi , Trizzino Antonino , Russo Giovanna , Cossu Fausto , Badolato Raffaele , Pietrogrande Maria Cristina , Quinti Isabella , Rossi Paolo , Ugazio Alberto , Pignata Claudio , Plebani Alessandro 
Published: August 2020

AbstractPrimary immunodeficiencies (PIDs) are heterogeneous disorders, characterized by variable clinical and immunological features. National PID registries offer useful insights on the epidemiology, diagnosis, and natural history of these disorders. In 1999, the Italian network for primary immunodeficiencies (IPINet) was established. We report on data collected from the IPINet registry after 20 years of activity. A total of 3352 pediatric and adult patients affected with PIDs are registered in the database. In Italy, a regional distribution trend of PID diagnosis was observed. Based on the updated IUIS classification of 2019, PID distribution in Italy showed that predominantly antibody deficiencies account for the majority of cases (63%), followed by combined immunodeficiencies with associated or syndromic features (22.5%). The overall age at diagnosis was younger for male patients. The minimal prevalence of PIDs in Italy resulted in 5.1 per 100.000 habitants. Mortality was similar to other European registries (4.2%). Immunoglobulin replacement treatment was prescribed to less than one third of the patient cohort. Collectively, this is the first comprehensive description of the PID epidemiology in Italy.
Textbooks, Postcards, and the Public Consolidation of Nationalism in Latin America
Authors: Kyriazi Anna , vom Hau Matthias 
Published: August 2020

AbstractThe existing macro-historical scholarship tends to assert rather than demonstrate the wider impact of nationalism. Yet, state-sponsored national ideologies permeate the broader reaches of society to varying degrees. To investigate variations in the consolidation of official nationalism, this paper combines the content analysis of school textbooks as state-regulated and picture postcards as primarily market-driven sources. Building on this novel methodological approach, we find that textbooks published in mid-twentieth-century Argentina, Mexico, and Peru promoted a similar popular nationalism that portrayed the lower classes as “true” national subjects. However, picture postcards from the same period demonstrate that the consolidation of this official national ideology varied. In Mexico and Peru, the new state-sponsored conceptions of nationhood gained presence in public life, but they did not to take hold in Argentina. We conclude that studying the top-down nationalist messages promoted by states should not be equated with studying their ideological impact in public life.
A retrospective assessment of the KLIK PROM portal implementation using the Consolidated Framework for Implementation Research (CFIR)
Authors: van Oers Hedy A. , Teela Lorynn , Schepers Sasja A. , Grootenhuis Martha A. , Haverman Lotte ,   the ISOQOL PROMs and PREMs in Clinical Practice Implementation Science Group
Published: August 2020

Abstract
Purpose
The KLIK Patient-Reported Outcome Measure (PROM) portal is an evidence-based intervention implemented in clinical practice in > 25 Dutch hospitals for patients (children and adults) who regularly visit the outpatient clinic. Implementation science frameworks can be used to understand why implementation succeeded or failed, to structure barriers and enablers, and to develop implementation strategies to overcome barriers. This paper aimed to (A) retrospectively describe determinants of successful KLIK PROM implementation using the Consolidated Framework for Implementation Research (CFIR), and (B) identify current barriers and match implementation strategies.

Methods
(A) The KLIK implementation process was described retrospectively based on literature and experience, using the 39 CFIR constructs organized in five general domains: intervention characteristics, outer setting, inner setting, characteristics of individuals, and implementation process. (B) The CFIR-Expert Recommendations for Implementing Change (ERIC) Implementation Strategy Matching tool identified current barriers in the KLIK implementation and matched implementation strategies that addressed the identified barriers.

Results
(A) The most prominent determinants of successful KLIK PROM implementation lie in the following CFIR domains: intervention characteristics (e.g., easy to use), characteristics of individuals (e.g., motivation), and process of implementation (e.g., support). (B) 13 CFIR constructs were identified as current barriers for implementing the KLIK PROM portal. The highest overall advised ERIC strategy for the specific KLIK barriers was to identify and prepare champions.

Conclusion
Using an implementation science framework, e.g., CFIR, is recommended for groups starting to use PROMs in clinical care as it offers a structured approach and provides insight into possible enablers and barriers.
Assessment of European and hybrid aspen clones efficiency based on height growth and removal percentage of petroleum hydrocarbons—a field trial
Authors: Salam Mir Md Abdus , Mohsin Muhammad , Rasheed Fahad , Ramzan Muhammad , Zafar Zikria , Pulkkinen Pertti 
Published: August 2020

AbstractSoils polluted by organic or inorganic pollutants are an emerging global environmental issue due to their toxic effects. A phytoremediation experiment was conducted to evaluate the extraction potential of three European aspen clones (R2, R3, and R4) and seven hybrid aspen clones (14, 27, 34, 134, 172, 191, and 291) grown in soils polluted with hydrocarbons (includes polycyclic aromatic hydrocarbons (PAH) and total petroleum hydrocarbons (TPH)). Height growth, plant survival rates, and .hydrocarbon removal efficiencies were investigated over a 4-year period at a site in Somerharju, Luumaki Finland, to assess the remediation potential of the clones. Hydrocarbon content in the soil was determined by gas chromatography and mass spectrometry. The results revealed that hybrid aspen clones 14 and 34 and European aspen clone R3 achieved greater height growth (171, 171, and 114 cm, respectively) than the other clones in the study. Further, the greatest removals of PAH (90% at depth 10–50 cm) and (86% at depth 5–10 cm) were observed in plot G15 planted with clone R2. Furthermore, the greatest TPH removal rate at 5–10 cm depth (C22–C40, 97%; C10–C40, 96%; and C10–C21, 90%) was observed in plot 117 with clone 134. However, other clones demonstrated an ability to grow in soils with elevated levels of TPH and PAH, which indicates their tolerance to hydrocarbons and their potential capacity for phytoremediation of hydrocarbon-polluted soils. Our study suggests that European aspen and hybrid aspen clones could be used for the remediation of soils polluted with PAH and TPH.
A TiN@Au-NR Plasmonic Structure with Tunable Surface Plasmon Resonance Depending on TiN to Au Thickness Ratio
Authors: Laghrissi Ayoub , Es-Souni Mohammed 
Published: August 2020

AbstractTiN nanostructures have been shown to exhibit promising plasmonic properties and are potential candidates for various applications, including energy harvesting. However, these properties also show a strong dependence on the processing conditions which have been reported to affect metallicity of TiN. Herein, we report on layered TiN@Au-nanorods (NRs) nanostructures consisting of 20 nm TiN thin layer that is magnetron sputtered on Au-NRs of variable length, yielding different TiN/Au thickness ratios (R). While a 20 nm TiN layer sputtered on the same substrate on which the Au-NRs are grown shows a weak absorption peak in the near IR region, an intense and broad plasmonic peak that lies red from the transverse plasmonic peak of monolithic Au-NRs layer is observed for TiN@Au-NRs. The red-shift is shown to increase with increasing R, attaining 100 nm for R = 1, together with an intense tail in the IR region. These results are interpreted in terms of a strong coupling between TiN and Au that drastically affects the plasmonic behavior of the structure. The results are contrasted with those on Pd@Au-NRs where only a slight blue-shift of few nanometers from the Au peak is observed. Potential applications of the TiN@Au-NRs are mainly in energy harvesting such as water splitting and photocatalysis using electromagnetic radiation in a broad wavelength range, as well as medical applications. Pd@Au-NRs may be used as electrocatalysts with plasmonic enhancement, e.g., for the hydrogen evolution reaction.
Handgrip Strength and Phase Angle Predict Outcome After Bariatric Surgery
Authors: Gerken A. L. H. , Rohr-Kräutle K-K. , Weiss C. , Seyfried S. , Reissfelder C. , Vassilev G. , Otto M. 
Published: August 2020

AbstractBackgroundThe amount of postoperative weight loss after bariatric surgery varies interindividually. The quality of the pre- and postoperative body composition is an important predictor of success. The aim of this study was to investigate the role of preoperative handgrip strength and phase angle (PhA) as predictors of sustained postoperative weight loss in order to assess the influence of body composition on the postoperative outcome after bariatric surgery.MethodIn a prospective cohort study, bioelectrical impedance and follow-up data of 198 patients after laparoscopic sleeve gastrectomy (SG;n = 68) and Roux-en-Y gastric bypass (GB;n = 130) were analyzed for a period of 36 months postoperatively.ResultsThe mean preoperative handgrip strength (31.48 kg, SD 9.97) correlates significantly with the postoperative body composition up to 24 months after surgery. Preoperative PhA, gender, size, and body weight influenced postoperative weight loss significantly. A significant correlation between preoperative PhA (mean 6.18°, SD 0.89°) and total weight loss (%TWL) was observed up to 3 months after SG (r = 0.31444,p = 0.0218) and up to 12 months after GB (r = 0.19184,p = 0.0467). The optimum cutoff for the prediction of a response of less than 50% excess weight loss was a preoperative PhA of 6.0°.ConclusionsThe preoperative handgrip strength confirmed its suitability for use as a predictor of postoperative body composition, whereas the preoperative PhA predicts postoperative weight loss after bariatric surgery. Further research is necessary to identify the role of these parameters for preconditioning.
The Changing Landscape of Lymphoma Associated with HIV Infection
Authors: Hübel Kai 
Published: August 2020

Abstract
Purpose of Review
Cancer remains a major cause of morbidity and mortality in HIV-infected individuals, with aggressive non-Hodgkin’s lymphoma as the most frequent one. However, the introduction of modern antiretroviral therapy (ART) drastically improved treatment options and prognosis in HIV-associated lymphomas. This review summarized the current treatment landscape and future challenges in HIV-positive patients with non-Hodgkin’s and Hodgkin’s lymphoma.

Recent Findings
Selecting the appropriate therapy for the individual patient, diffuse-large B cell lymphoma, Burkitt’s lymphoma, and Hodgkin’s disease may be curable diseases. In contrast, the prognosis of plasmablastic lymphoma and primary effusion lymphoma remain poor. New treatment approaches, as targeted therapies or CAR T cell therapy, may broaden the therapeutic armamentarium.

Summary
The continuous application of ART is mandatory for successful treatment. The choice of lymphoma therapy may follow the recommendations for HIV-negative patients, but prospective trials in HIV-lymphoma are needed.
SIRT1+ Adipose Derived Mesenchymal Stromal Stem Cells (ASCs) Suspended in Alginate Hydrogel for the Treatment of Subchondral Bone Cyst in Medial Femoral Condyle in the Horse. Clinical Report
Authors: Golonka Paweł , Kornicka-Garbowska Katarzyna , Marycz Krzysztof 
Published: August 2020

AbstractStem cell based therapy are now commonly applied in human and veterinary medical practice especially in orthopaedics. Mesenchymal stromal stem cells isolated from adipose tissue (ASC) are first choice option due to relatively non-invasive and safe procedure of tissue harvesting. However, ASC therapeutic potential strongly rely on patients general health condition, age and life-style. For that reason, to enhance therapeutic potential of cells, they are modifiedin vitrousing different approaches. Previous studies have shown, that ASC treated with resveratrol, herein called SIRT+, are characterised by decreased senescence, increased proliferation rate and improved clinical outcome in autologous therapies. Herein, SIRT + cells in alginate hydrogel were applied to 5 years old warm breed mare was clinically evaluated due to the left hind lameness due to subchondral bone cyst. The therapeutic effect was assessed by the analysis of lameness score and radiological evaluation. This case report demonstrates the therapeutic potential of SIRT + cells in the treatment of orthopaedics disorders in horses as complete bone remodelling occurred after therapy and horse came back to training.
Entrepreneurial elements of human smuggling rings: findings from a multiple case study
Authors: Costantino Fabrizio , Di Nicola Andrea 
Published: August 2020

AbstractHuman smuggling towards Europe has reached an unprecedented level in the last years. The past decade has seen an intensification of the demand for irregular migration services, which increased the role of smuggling rings as service providers to assist irregular migrants in evading national border controls, migration regulations and visa requirements. These criminal organizations feature an entrepreneurial, rent-seeking behaviour using methods such as corruption, deceit, violence, and threats. Literature observes a number of elements which are essential for the establishment and development of any criminal organisation (capital collection, profit maximisation, differentiation of tasks, systems to conceal criminal money flows), but their actual presence within the human smuggling rings has never been verified. Using secondary sources, this contribution aims at verifying the presence of these entrepreneurial elements in the case of human smuggling rings by using a multiple case-study analysis.
The role of foxes in the Palaeolithic economies of the Swabian Jura (Germany)
Authors: Baumann Chris , Wong Gillian L. , Starkovich Britt M. , Münzel Susanne C. , Conard Nicholas J. 
Published: August 2020

AbstractIn this study, we examine the role of foxes in Palaeolithic economies, focusing on sites of the Middle Palaeolithic, Aurignacian, Gravettian and Magdalenian of the Swabian Jura. For this purpose, we used published faunal data from 26 assemblages from the region, including new information from the Magdalenian layers of Langmahdhalde. We explore how the abundance of foxes changes over time, how they were used by humans, and how they were deposited at the sites, with a special focus on fox hunting methods. To evaluate these hunting methods, we use the prey choice model of optimal foraging theory (OFT) and simulate possible hunting scenarios, which we test based on the published faunal assemblages. Our research indicates that foxes were hunted since the early Upper Palaeolithic for their meat, fur and teeth, possibly with traps. We find that the abundance of fox remains in the archaeological record of the region increased continuously starting in the Aurignacian, which cannot be explained by taphonomic factors. The trend of foxes to adapt to human-influenced environments with commensal behavior may also have contributed to them being hunted more often.