bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do non-governmental organizations bring change or maintain the status quo in times of crisis? A case study of the Marikana massacre in South Africa
Authors: Langa Malose , Rebello Steven , Harms-Smith Linda 
Published: October 2019

Abstract
This article reflects on the Marikana massacre of August 2012, subsequent violent strikes and responses by non-governmental organizations (NGOs) as a case study, and provides an analysis about whether these interventions bring transformative change or maintain the status quo in times of crisis. Events associated with Marikana are seen to be embedded in social structures of the time and part of deeper frictions and fractures of social transformation. The role that NGOs might play in this context must be interrogated as to their facilitation or hinderance of such social transformation. Interviews were conducted with representatives of NGOs intervening in Marikana that provided services of humanitarian assistance, and legal and psychosocial interventions and with mine workers and residents of Marikana about their experiences and views of these services. Findings from the study are illustrative of how NGOs were not primarily motivated to bring about lasting, transformative change but rather attempted to address immediate or short-term needs which, while important, did not account for underlying causes of the crises that they set out to address. Both ideological underpinnings of NGOs and structural conditions produced by state and capital impact on outcomes of interventions. Given these limitations, it is argued that there is a need for deep critical interrogation through praxis, for NGOs to intervene differently in times of crisis to bring ‘real’ change and transformation in the lives of those who are marginalized.
Liquid Chromatographic Method Development for Quantification of Inorganic Nitrite and Nitrate Impurities from Nitroglycerin Drug Substance by Using Ion-Pair Reagents with Liquid–Liquid Extraction Technique
Authors: Desai Pritesh R , Mehta Priti J , Chokshi Avani B 
Published: October 2019

Abstract
A large number of laboratory studies have reported Nitrite (NO2−) and Nitrate (NO3−) to be among the most common degradation products of the high-explosive Nitroglycerin drug substance. A novel, simple, robust and rapid reversed-phase high-performance liquid chromatography method has been developed for quantification of inorganic Nitrite and Nitrate impurities from Nitroglycerin drug substance. Successful separation was achieved in isocratic elution, using Inertsil C8-3, (250 × 4.6 mm, 5.0 μm) column, with mobile phase consisting of pH 7.0 tetrabutyl ammonium hydrogen sulfate buffer, methanol and acetonitrile (96:02:02, v/v/v). Flow rate was monitored at 2.0 mL min−1 and ultraviolet detection at 220 nm. The present work describes the role of an ion-pair reagent in the separation of polar compounds and liquid–liquid extraction technique for separation of polar and non-polar compounds. Nitroglycerin was subjected to various stress conditions to demonstrate the stability-indicating power of the method. The performance of the method was validated as per present International Council for Harmonisation (ICH) guidelines for specificity, linearity, accuracy, precision, ruggedness and robustness. The developed method can be a valuable alternative to the current ion-exchange chromatographic method mentioned in the literature. To the best of our knowledge, a rapid Liquid Chromatography (LC) method, which separates inorganic Nitrite and Nitrate impurities of Nitroglycerin, disclosed in this investigation was not published elsewhere.
Herpes Zoster Risk in Immunocompromised Adults in the United States: A Systematic Review
Authors: McKay Susannah L , Guo Angela , Pergam Steven A , Dooling Kathleen 
Published: October 2019

Abstract

Background
The primary reported risk factors for herpes zoster (HZ) include increasing age and immunodeficiency, yet estimates of HZ risk by immunocompromising condition have not been well characterized. We undertook a systematic literature review to estimate the HZ risk in immunocompromised patients.

Methods
We systematically reviewed studies that examined the risk of HZ and associated complications in adult patients with hematopoietic cell transplants (HCT), cancer, human immunodeficiency virus (HIV), and solid organ transplant (SOT). We identified studies in PubMed, Embase, Medline, Cochrane, Scopus, and clinicaltrials.gov that presented original data from the United States and were published after 1992. We assessed the risk of bias with Cochrane or Grading of Recommendations Assessment, Development, and Evaluation methods.

Results
We identified and screened 3765 records and synthesized 34 studies with low or moderate risks of bias. Most studies that were included (32/34) reported at least 1 estimate of the HZ cumulative incidence (range, 0–41%). There were 12 studies that reported HZ incidences that varied widely within and between immunocompromised populations. Incidence estimates ranged from 9 to 92 HZ cases/1000 patient-years and were highest in HCT, followed by hematologic malignancies, SOT, and solid tumor malignancies, and were lowest in people living with HIV. Among 17 HCT studies, the absence of or use of antiviral prophylaxis at &lt;1 year post-transplant was associated with a higher HZ incidence.

Conclusions
HZ was common among all immunocompromised populations studied, exceeding the expected HZ incidence among immunocompetent adults aged ≥60 years. Better evidence of the incidence of HZ complications and their severity in immunocompromised populations is needed to inform economic and HZ vaccine policies.
Sarcoidosis Mimicking Crohn Disease
Authors: Rubin Jonah N , George Lauren A , Cross Raymond K , Wong Uni 
Published: October 2019

Abstract
Intestinal sarcoidosis can mimic Crohn disease (CD), and it is important to evaluate for alternative diagnoses in patients who present with atypical symptoms or do not respond to conventional therapy. Furthermore, CD, with or without biologic therapy, has been associated with neurological symptoms including neuropathies, myelopathies, thromboembolic, and demyelinating diseases leading to diagnostic uncertainty. We present a case of sarcoidosis of the luminal gastrointestinal tract and central nervous system, which mimicked the presentation of CD. This case highlights the need to expand the differential diagnosis in patients who present with atypical symptoms and do not respond to biologic therapy.
The kinetics of colour degradation, chlorophylls and xanthophylls loss in pistachio nuts during roasting process
Authors: Dini Ali , Khanamani Falahati-Pour Soudeh , Behmaram Khosro , Sedaghat Nasser 
Published: October 2019

Abstract

Objectives
Colour is amongst the parameter which is used for process control during roasting.

Materials and Methods
In this study, the effects of hot air roasting temperature (120, 130, 145, 160, and 170°C) and hot air velocity (0.6, 1.3, and 2 m/s) on colour change kinetics of pistachio nuts were investigated by employing image analysis and simultaneously chlorophylls and xanthophylls (lutein and β-carotenoid) concentration were determined by spectrophotometric measurement method.

Results
We found that roasting temperature and hot air velocity had significant effect on colour changes. There is a correlation between a- and b-value with chlorophylls and xanthophylls concentration, respectively. The roasting temperature was found to be the main factor affecting colour development. The variations in the pigments concentration and colour parameters of pistachio nuts were adequately simulated by quadratic and cubic polynomials. The changes in L-, b-values, and xanthophylls degradation were well-fitted to the first-order kinetic model while a-value and chlorophylls degradation followed the zero-order kinetic. The activation energy was determined at 113.9, 116.7, and 117.2 kJ/mol with R2 ≥ 99.9 and 191, 195, and 163.2 kJ/mol with R2 ≥ 99.5 and 73.7, 71.3, and 81.6 kJ/mol with R2 ≥ 99.9 for L-, b-, and a-value in hot air velocity of 0.6, 1.3, and 2 m/s, respectively.

Conclusions
Activation energy of chlorophylls and xanthophylls degradation were in the range of the activation energy for the yellowness (b-value) and redness (a-value) reactions.
Hospital readmission following transjugular intrahepatic portosystemic shunt: a 14-year single-center experience
Authors: Vozzo Catherine F , Singh Tavankit , Bullen Jennifer , Sarvepalli Shashank , McCullough Arthur , Kapoor Baljendra 
Published: October 2019

AbstractBackgroundPlacement of a transjugular intrahepatic portosystemic shunt (TIPS) is a relatively common procedure used to treat complications of portal hypertension. However, only limited data exist regarding the hospital-readmission rate after TIPS placement and no studies have addressed the causes of hospital readmission. We therefore sought to identify the 30-day hospital-readmission rate after TIPS placement at our institution and to determine potential causes and predictors of readmission.MethodsWe reviewed our electronic medical-records system at our institution between 2004 and 2017 to identify patients who had undergone primary TIPS placement with polytetrafluoroethylene-covered stents and to determine the 30-day readmission rate among these patients. A series of univariable logistic-regression models were fit to assess potential predictors of 30-day readmission.ResultsA total of 566 patients were included in the analysis. The 30-day readmission rate after TIPS placement was 36%. The most common causes for readmission were confusion (48%), infection (15%), bleeding (11%), and fluid overload (7%). A higher Model for End-Stage Liver Disease (MELD) score corresponded with a higher rate of readmission (odds ratio associated with each 1-unit increase in MELD score: 1.06; 95% confidence interval: 1.02–1.09; P = 0.001). Other potential predictors, including indication for TIPS placement, were not significantly associated with a higher readmission rate.ConclusionsThe 30-day readmission rate after TIPS placement with covered stents is high, with nearly half of these readmissions due to hepatic encephalopathy—a known complication of TIPS placement. Novel interventions to help reduce the TIPS readmission rate should be prioritized in future research.
How Well Do You Think You Summarize? Metacomprehension Accuracy in Younger and Older Adults
Authors: Fulton Erika K 
Published: October 2019

Abstract

Objectives
Metacomprehension monitoring accuracy in older age may be underestimated because of how it has been measured. Metacomprehension in the present study was uniquely measured by comparing summary quality to summary quality judgments. The effect of age on this accuracy was assessed and results were compared to those measured with the typical approach. The moderation of age effects by reading goal was also assessed but was an exploratory objective.1

Method
Younger adults (141) and older adults (138) read and orally summarized six expository texts. Participants were randomly assigned to a reading goal condition, with half of each age group summarizing for a professor/boss and half summarizing for an acquaintance. Participants made judgments about the quality of their summaries before and after summarizing, took a multiple-choice test of their comprehension, and made judgments about the accuracy of their answers.

Results
Age deficits in metacomprehension were generally smaller when measured with the novel approach and age differences were generally larger for the professor/boss condition than for the acquaintance condition.

Discussion
The novel approach to measuring metacomprehension monitoring accuracy provides more optimism for aging than typical approaches, discussed in relation to age-related changes in language processing preferences.
Risk Factors for Medication Nonadherence to Self-Injectable Biologic Therapy in Adult Patients With Inflammatory Bowel Disease
Authors: Shah Nisha B , Haydek Jennifer , Slaughter James , Ashton Jonathan R , Zuckerman Autumn D , Wong Rochelle , Raffa Francesca , Garrett Ailish , Duley Caroline , Annis Kim , Wagnon Julianne , Gaines Lawrence , Dalal Robin , Scoville Elizabeth , Beaulieu Dawn B , Schwartz David , Horst Sara N 
Published: October 2019

Abstract

Background
In inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), nonadherence to biologic therapy increases risk of disease flare. The aim of this study was to identify risk factors for nonadherence.

Methods
This was a single-center retrospective study evaluating patients with IBD treated at a tertiary care center and prescribed self-injectable biologic therapy using the center’s specialty pharmacy. Adherence was defined using medication possession ratio (MPR). Nonadherence was defined as MPR &lt;0.86.

Results
Four hundred sixty patients (n = 393 with CD and n = 67 with UC) were evaluated with mean MPR (interquartile range) equaling 0.89 (0.48–1). Overall, 69% of patients were adherent (defined as MPR ≥0.86), 66% of patients with CD and 87% of patients with UC. In univariate analysis, several factors increased risk of nonadherence: CD diagnosis, insurance type, psychiatric history, smoking, prior biologic use, and narcotic use (P &lt; 0.05). In multivariable analysis, Medicaid insurance (odds ratio [OR], 5.5; 95% confidence interval [CI], 1.85–15.6) and CD diagnosis (OR, 2.8; 95% CI, 1.3–6.0) increased risk of nonadherence. In CD, as the number of risk factors increased (narcotic use, psychiatric history, prior biologic use, and smoking), the probability of nonadherence increased. Adherence was 72% in patients with 0–1 risk factors, decreasing to 62%, 61%, and 42% in patients with 2, 3, and 4 risk factors, respectively (P &lt; 0.05).

Conclusions
This study identified risk factors for nonadherence to biologic therapy. In patients with CD, the probability of nonadherence increased as the number of risk factors increased.
Molecular Breast Imaging in Patients with Suspicious Calcifications
Authors: Hunt Katie N , Hruska Carrie B , Johnson Matthew P , Conners Amy Lynn , O’connor Michael K , Rhodes Deborah J , Basappa Susanna , Wahner-Roedler Dietlind 
Published: October 2019

AbstractObjectiveWe evaluated the accuracy of molecular breast imaging (MBI)—a nuclear medicine technique that employs dedicated dual-detector, cadmium zinc telluride gamma cameras to image the functional uptake of a radiopharmaceutical (typically Tc-99m sestamibi) in the breast—in patients with suspicious calcifications on mammography.MethodsWomen scheduled for stereotactic biopsy of calcifications detected on 2D digital mammography were prospectively enrolled to undergo MBI before biopsy. Molecular breast imaging was performed with injection of Tc-99m sestamibi and a dual-detector, cadmium zinc telluride gamma camera. Positive findings on either modality were biopsied. High-risk and malignant biopsy findings were excised.ResultsIn 71 participants, 76 areas of calcifications were recommended for biopsy after mammography, and 24 (32%) were malignant, including 20 cases of ductal carcinoma in situ (DCIS) and 4 cases of invasive ductal cancer. Prebiopsy MBI was positive in 17 of the 76 (22%) calcifications, including 10 of 20 (50%) DCISs and 2 of 4 (50%) invasive cancers. The median pathologic size for MBI–positive cancers was 1.5 cm (range 0.5–3.2 cm) compared with 0.9 cm (range 0.1–2.0 cm) for MBI–negative cancers (P = 0.09).Non-mass uptake on MBI led to additional biopsies of 6 sites in 6 patients, and 2 of 6 (33%) MBI–detected incidental lesions showed malignancy; both DCIS contralateral to the mammographically detected calcifications. The overall per-lesion positive and negative predictive values of MBI in this prebiopsy setting were 61% (14 of 23) and 80% (47 of 59), respectively.ConclusionMolecular breast imaging has insufficient negative predictive value to identify calcifications in which biopsy could be avoided. However, among women presenting for biopsy of suspicious calcifications, MBI revealed additional sites of mammographically occult breast cancer.To avoid biopsy of suspicious calcifications on mammography, negative findings on MBI should not be used.
Maternal miR-202-5p is required for zebrafish primordial germ cell migration by protecting small GTPase Cdc42
Authors: Jin Yilin , Liu Wei , Xiang Yangxi , Zhang Wanwan , Zhang Hong , Jia Kuntong , Yi Meisheng 
Published: October 2019

Abstract
In many lower animals, germ cell formation, migration, and maintenance depend on maternally provided determinants in germ plasm. In zebrafish, these processes have been extensively studied in terms of RNA-binding proteins and other coding genes. The role of small non-coding RNAs in the regulation of primordial germ cell (PGC) development remains largely unknown and poorly investigated, even though growing interests for the importance of miRNAs involved in a wide variety of biological processes. Here, we reported the role and mechanism of the germ plasm-specific miRNA miR-202-5p in PGC migration: (i) both maternal loss and knockdown of miR-202-5p impaired PGC migration indicated by the mislocalization and reduced number of PGCs; (ii) cdc42se1 was a direct target gene of miR-202-5p, and overexpression of Cdc42se1 in PGCs caused PGC migration defects similar to those observed in loss of miR-202-5p mutants; (iii) Cdc42se1 not only interacted with Cdc42 but also inhibited cdc42 transcription, and overexpression of Cdc42 could rescue PGC migration defects in Cdc42se1 overexpressed embryos. Thus, miR-202-5p regulates PGC migration by directly targeting and repressing Cdc42se1 to protect the expression of Cdc42, which interacts with actin to direct PGC migration.
A rare case of FR I interaction with a hot X-ray bridge in the A2384 galaxy cluster
Authors: Parekh V , Laganá T F , Thorat K , Heyden K van der , Iqbal A , Durret F 
Published: October 2019

Abstract
Clusters of varying mass ratios can merge and the process significantly disturbs the cluster environments and alters their global properties. Active radio galaxies are another phenomenon that can also affect cluster environments. Radio jets can interact with the intra-cluster medium (ICM) and locally affect its properties. Abell 2384 (hereafter A2384) is a unique system that has a dense, hot X-ray filament or bridge connecting the two unequal mass clusters A2384(N) and A2384(S). The analysis of its morphology suggests that A2384 is a post-merger system where A2384(S) has already interacted with the A2384(N), and as a result hot gas has been stripped over a ∼1 Mpc region between the two bodies. We have obtained its 325 MHz GMRT data, and we detected a peculiar FR I type radio galaxy which is a part of the A2384(S). One of its radio lobes interacts with the hot X-ray bridge and pushes the hot gas in the opposite direction. This results in displacement in the bridge close to A2384(S). Based on Chandra and XMM-Newton X-ray observations, we notice a temperature and entropy enhancement at the radio lobe-X-ray plasma interaction site, which further suggests that the radio lobe is changing thermal plasma properties. We have also studied the radio properties of the FR I radio galaxy, and found that the size and radio luminosity of the interacting north lobe of the FR I galaxy are lower than those of the accompanying south lobe.
uGMRT search for cold gas at z ∼ 1–1.4 towards red quasars
Authors: Dutta R , Raghunathan S , Gupta N , Joshi R 
Published: October 2019

ABSTRACT
We present results from our search for H i 21-cm and OH 18-cm absorption at z ∼ 1–1.4 towards red quasars showing strong Mg ii absorption using upgraded Giant Metrewave Radio Telescope. The quasars J1501 + 1822 and J1521 + 5508 show multiple strong associated Mg ii absorption at z ∼ 1.1 and signature of reddening in their optical spectra. We report the detection of H i 21-cm absorption towards J1521 + 5508 at the systemic redshift of the quasar, with $N(\rm{H\,{\small I}}$) = (1.2 ± 0.2) × 1020 cm−2 for spin temperature of 100 K and unit covering factor. The H i 21-cm absorption is offset from the blueshifted strong Mg ii absorbers by ≳1500 km s−1. We do not detect H i 21-cm absorption at the redshift of the associated Mg ii absorption and at the systemic redshift towards J1501 + 1822. We argue that lack of one-to-one correspondence between Mg ii and H i 21-cm absorption could be related with clumpiness of the neutral gas and the radio and optical sightlines probing different volume of the gas. We find that the presence of strong associated Mg ii absorption and reddening in the optical spectra of the quasars lead to an increased detection rate of associated H i 21-cm absorption at z ≥1. We also report non-detection of intervening OH absorption ([OH]/[H i] ≤ (1–4)× 10−8) at z = 1.3 towards two red quasars, J0850 + 5159 and J0852 + 3435, which show strong metal and H i 21-cm absorption and the 2175 Å dust extinction bump.
Detecting gravitational self-lensing from stellar-mass binaries composed of black holes or neutron stars
Authors: D’Orazio Daniel J , Stefano Rosanne Di 
Published: October 2019

ABSTRACT
We explore a unique electromagnetic signature of stellar-mass compact-object binaries long before they are detectable in gravitational waves. We show that gravitational lensing of light emitting components of a compact-object binary, by the other binary component, could be detectable in the nearby Universe. This periodic lensing signature could be detected from present and future X-ray observations, identifying the progenitors of binaries that merge in the LIGO band, and also unveiling populations that do not merge, thus providing a tracer of the compact-object binary population in an enigmatic portion of its life. We argue that periodically repeating lensing flares could be observed for ≲100 ks orbital-period binaries with the future Lynx X-ray mission, possibly concurrent with gravitational wave emission in the LISA band. Binaries with longer orbital periods could be more common and be detectable as single lensing flares, though with reliance on a model for the flare that can be tested by observations of succeeding flares. Non-detection of such events, even with existing X-ray observations, will help to constrain the population of EM bright compact-object binaries.
Targeted PMP22 TATA-box editing by CRISPR/Cas9 reduces demyelinating neuropathy of Charcot-Marie-Tooth disease type 1A in mice
Authors: Lee Ji-Su , Lee Jae Y , Song Dong W , Bae Hee S , Doo Hyun M , Yu Ho S , Lee Kyu J , Kim Hee K , Hwang Hyun , Kwak Geon , Kim Daesik , Kim Seokjoong , Hong Young B , Lee Jung M , Choi Byung-Ok 
Published: October 2019

AbstractCharcot-Marie-Tooth 1A (CMT1A) is the most common inherited neuropathy without a known therapy, which is caused by a 1.4 Mb duplication on human chromosome 17, which includes the gene encoding the peripheral myelin protein of 22 kDa (PMP22). Overexpressed PMP22 protein from its gene duplication is thought to cause demyelination and subsequently axonal degeneration in the peripheral nervous system (PNS). Here, we targeted TATA-box of human PMP22 promoter to normalize overexpressed PMP22 level in C22 mice, a mouse model of CMT1A harboring multiple copies of human PMP22. Direct local intraneural delivery of CRISPR/Cas9 designed to target TATA-box of PMP22 before the onset of disease, downregulates gene expression of PMP22 and preserves both myelin and axons. Notably, the same approach was effective in partial rescue of demyelination even after the onset of disease. Collectively, our data present a proof-of-concept that CRISPR/Cas9-mediated targeting of TATA-box can be utilized to treat CMT1A.