bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in the development of nanoparticle‐based imaging agents: Characterization and biology
Authors: Crist Rachael M. , Dasa Siva Sai Krishna , Liu Christina H. , Clogston Jeffrey D. , Dobrovolskaia Marina A. , Stern Stephan T. 
Published: August 2020

AbstractDespite imaging agents being some of the earliest nanomedicines in clinical use, the vast majority of current research and translational activities in the nanomedicine field involves therapeutics, while imaging agents are severely underrepresented. The reasons for this lack of representation are several fold, including difficulties in synthesis and scale‐up, biocompatibility issues, lack of suitable tissue/disease selective targeting ligands and receptors, and a high bar for regulatory approval. The recent focus on immunotherapies and personalized medicine, and development of nanoparticle constructs with better tissue distribution and selectivity, provide new opportunities for nanomedicine imaging agent development. This manuscript will provide an overview of trends in imaging nanomedicine characterization and biocompatibility, and new horizons for future development.This article is categorized under:Diagnostic Tools > in vivo Nanodiagnostics and ImagingToxicology and Regulatory Issues in Nanomedicine > Toxicology of NanomaterialsToxicology and Regulatory Issues in Nanomedicine > Regulatory and Policy Issues in Nanomedicine
Followership Identity Work
Authors: Thompson Rachael 
Published: August 2020

AbstractThis chapter focuses on notions of identity and followership, and presents a process for follower identity development. As areas separately seeing growth in academic popularity over the years, the author is keen to bring them together in the hope of further enabling students to connect with their own followership identities, much in the way that they are supported to become aware of and to develop their leadership identities.
Development of a Followership Teaching Strategy in Indonesia
Authors: Nurhadi Muhsin B. 
Published: August 2020

AbstractThis chapter is based on the author's personal journey to attempt to bring an understanding of followership to Indonesia. Followership has been understudied and underappreciated in both academic literature and practice in Indonesia, possibly because of a specific interpretation of a famous Islamic leadership hadith. As such, it presents a powerful example of a cultural analysis that could be useful in other contexts. It also includes challenges that may be encountered teaching followership in Indonesia, and specific teaching strategies that can be used.
A hinge position distal to the adductor tubercle minimizes the risk of hinge fractures in lateral open wedge distal femoral osteotomy
Authors: Winkler Philipp W. , Rupp Marco C. , Lutz Patricia M. , Geyer Stephanie , Forkel Philipp , Imhoff Andreas B. , Feucht Matthias J. 
Published: August 2020

Abstract
Purpose
To evaluate the incidence and morphology of medial cortical hinge fractures in lateral open wedge distal femoral osteotomy (LOW-DFO) and to determine a safe zone for the position of the osteotomy hinge to minimize the risk of hinge fractures.

Methods
Consecutive patients who underwent LOW-DFO for symptomatic valgus malalignment were screened for eligibility for this retrospective observational cohort study. Demographical and surgical data were collected. The incidence and morphology of medial cortical hinge fractures were evaluated on standard postoperative anterior–posterior knee radiographs. Comprehensive measurements evaluating the osteotomy gap and the position of the osteotomy hinge were taken. Additionally, each osteotomy hinge was assigned to a corresponding sector of a proposed five-sector grid of the distal medial femur.

Results
A total of 100 patients (60% female) with a mean age of 31 ± 13 years were included. The overall incidence of medial cortical hinge fractures was 46% and three distinct fracture types were identified. The most frequently observed fracture type was extension of the osteotomy gap (76%), followed by a proximal (20%) and distal (4%) course of the fracture line in relation to the hinge. Group comparison (hinge fracture vs. no hinge fracture) showed statistically significant higher values for the height of the osteotomy gap (p = 0.001), the wedge angle (p = 0.036), and the vertical distance between the hinge and the proximal margin of the adductor tubercle (AT; p = 0.002) in the hinge fracture group. Furthermore, a significantly lower horizontal distance between the hinge and the medial cortical bone (p = 0.036) was observed in the hinge fracture group. A statistically significant higher incidence of medial cortical hinge fractures was observed when the position of the osteotomy hinge was proximal compared to distal to the proximal margin of the AT (53% vs. 27%; p = 0.023).

Conclusion
Medial cortical hinge fractures in LOW-DFO are a common finding with three distinct fracture types. To minimize the risk of medial cortical hinge fractures, it is recommended to aim for a position of the osteotomy hinge at the level of or distal to the proximal margin of the adductor tubercle.

Level of evidence
Prognostic study; Level III
Quantitative determination and validation of 17 cannabinoids in cannabis and hemp using liquid chromatography-tandem mass spectrometry
Authors: McRae Garnet , Melanson Jeremy E. 
Published: August 2020

AbstractThe increase in production of cannabis for medical and recreational purposes in recent years has led to a corresponding increase in laboratories performing cannabinoid analysis of cannabis and hemp. We have developed and validated a quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) method that is simple, reliable, specific, and accurate for the analysis of 17 cannabinoids in cannabis and hemp. Liquid-solid sample extraction coupled with dilution into a calibration range from 10 to 10,000 ng/mL and LC-MS/MS analysis provides quantification of samples ranging from 0.002 to 200 mg/g (0.0002 to 20.0%) in matrix. Linearity of calibration curves in methanol was demonstrated with regression r2 ≥ 0.99. Within-batch precision (0.5 to 6.5%) and accuracy (91.4 to 108.0%) and between-batch precision (0.9 to 5.1%) and accuracy (91.5 to 107.5%) were demonstrated for quality control (QC) samples in methanol. Within-batch precision (0.2 to 3.6%) and accuracy (85.4 to 111.6%) and between-batch precision (1.4 to 6.1 %) and accuracy (90.2 to 110.3%) were also evaluated with a candidate cannabis certified reference material (CRM). Repeatability (1.5 to 12.4% RSD) and intermediate precision (2.2 to 12.8% RSD) were demonstrated via analysis of seven cannabis samples with HorRat values ranging from 0.3 to 3.1. The method provides enhanced detection limits coupled with a large quantitative range for 17 cannabinoids in plant material. It is suitable for a wide range of applications including routine analysis for delta-9-tetrahydrocannabinol (Δ9-THC), delta-9-tetrahydrocannabinolic acid (Δ9-THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabinol (CBN) as well as more advanced interrogation of samples for both major and minor cannabinoids.
Optical ammonia sensors based on fluorescent aza-BODIPY dyes— a flexible toolbox
Authors: Maierhofer Maximilian , Rieger Veronika , Mayr Torsten 
Published: August 2020

AbstractWe present three types of optical ammonia sensors suitable for environmental, bioprocess, and reaction monitoring. A respective fluorescent BF2-chelated tetraarylazadipyrromethene dye (aza-BODIPYs) is physically entrapped in a polyurethane hydrogel (HydroMed D4) forming an emulsion system with vinyl-terminated polydimethylsiloxane (PDMS). The analyte-sensitive layer is covered by a hydrophobic membrane which excludes hydrophilic substances. Three different protection layers are tested, whereby the Teflon and the hydrophobic PES layers outperform a PDMS/TiO2 layer. Response times within their dynamic range of 15 s can be achieved, whereas the PDMS/TiO2-covered sensor requires at least 390 s. The three sensors entail the following concentration areas: first sensor 3 μg L−1–3 mg L−1 (LOD 0.23 μg L−1), second sensor 0.1–30 mg L−1 (LOD 28 μg L−1), and third sensor 3 mg L−1–1 g L−1 (LOD 0.51 mg L−1). Readout is performed with a commercially available phase fluorimeter combined with optical fibers. Dual-lifetime referencing (DLR) is used as referencing method and Egyptian blue acts as an inert reference material. No cross-sensitivity to pH changes can be detected.
Simultaneous portal and hepatic vein embolization before major liver resection
Authors: Heil Jan , Schadde Erik 
Published: August 2020

Abstract
Background
Regenerative liver surgery expands the limitations of technical resectability by increasing the future liver remnant (FLR) volume before extended resections in order to avoid posthepatectomy liver failure (PHLF). Portal vein rerouting with ligation of one branch of the portal vein bifurcation (PVL) or embolization (PVE) leads to a moderate liver volume increase over several weeks with a clinical dropout rate of 20–40%, mostly due to tumor progression during the waiting period. Accelerated liver regeneration by the Associating Liver Partition and Portal vein Ligation for Staged hepatectomy (ALPPS) was poised to overcome this limitation by reduction of the waiting time, but failed due increased perioperative complications. Simultaneous portal and hepatic vein embolization (PVE/HVE) is a novel minimal invasive way to induce rapid liver growth without the need of two surgeries.

Purpose
This article summarizes published results of PVE/HVE and analyzes what is known about its efficacy to achieve resection, safety, and the volume changes induced.

Conclusions
PVE/HVE holds promise to induce accelerated liver regeneration in a similar safety profile to PVE. The demonstrated accelerated hypertrophy may increase resectability. Randomized trials will have to compare PVE/HVE and PVE to determine if PVE/HVE is superior to PVE.
How robust are landslide susceptibility estimates?
Authors: Ozturk Ugur , Pittore Massimiliano , Behling Robert , Roessner Sigrid , Andreani Louis , Korup Oliver 
Published: August 2020

AbstractMuch of contemporary landslide research is concerned with predicting and mapping susceptibility to slope failure. Many studies rely on generalised linear models with environmental predictors that are trained with data collected from within and outside of the margins of mapped landslides. Whether and how the performance of these models depends on sample size, location, or time remains largely untested. We address this question by exploring the sensitivity of a multivariate logistic regression—one of the most widely used susceptibility models—to data sampled from different portions of landslides in two independent inventories (i.e. a historic and a multi-temporal) covering parts of the eastern rim of the Fergana Basin, Kyrgyzstan. We find that considering only areas on lower parts of landslides, and hence most likely their deposits, can improve the model performance by >10% over the reference case that uses the entire landslide areas, especially for landslides of intermediate size. Hence, using landslide toe areas may suffice for this particular model and come in useful where landslide scars are vague or hidden in this part of Central Asia. The model performance marginally varied after progressively updating and adding more landslides data through time. We conclude that landslide susceptibility estimates for the study area remain largely insensitive to changes in data over about a decade. Spatial or temporal stratified sampling contributes only minor variations to model performance. Our findings call for more extensive testing of the concept of dynamic susceptibility and its interpretation in data-driven models, especially within the broader framework of landslide risk assessment under environmental and land-use change.
Efficacy of the eribulin, pertuzumab, and trastuzumab combination therapy for human epidermal growth factor receptor 2–positive advanced or metastatic breast cancer: a multicenter, single arm, phase II study (JBCRG-M03 study)
Authors: Yamashita Toshinari , Kawaguchi Hidetoshi , Masuda Norikazu , Kitada Masahiro , Narui Kazutaka , Hattori Masaya , Yoshinami Tetsuhiro , Matsunami Nobuki , Yanagihara Kazuhiro , Kawasoe Teru , Nagashima Takeshi , Bando Hiroko , Yano Hiroshi , Hasegawa Yoshie , Nakamura Rikiya , Kashiwaba Masahiro , Morita Satoshi , Ohno Shinji , Toi Masakazu 
Published: August 2020

SummaryPurpose To date, it is not clear which anticancer agent is useful in combination with trastuzumab and pertuzumab As the first and second selective regimens for advanced or metastatic breast cancer (AMBC), this multicenter, open-label, phase II trial (JBCRG-M03: UMIN000012232) presents a prespecified analysis of eribulin in combination with pertuzumab and trastuzumab. Methods We enrolled 50 patients with no or single prior chemotherapy for HER2-positive AMBC during November 2013–April 2016. All patients received adjuvant or first-line chemotherapy with trastuzumab and a taxane. The treatment comprised eribulin on days 1 and 8 of a 21-day cycle and trastuzumabplus pertuzumab once every 3 weeks, all administered intravenously. While the primary endpoint was the progression-free survival (PFS), secondary endpoints were the response rate and safety. Results Of 50 patients, 49 were eligible for safety analysis, and the full analysis set (FAS) included 46 patients. We treated 8 (16%) and 41 (84%) patients in first- and second-line settings, respectively. While 11 patients (23.9%) had advanced disease, 35 (76.1%) had metastatic disease. The median PFS was 9.2 months for all patients [95% confidence interval (CI): 7.0–11.4]. In the FAS, 44 patients had the measurable lesions and the complete response rate (CR) was 17.4%, and partial response rate (PR) was 43.5%. The grade 3/4 adverse events were neutropenia (5 patients, 10.2%), including febrile neutropenia (2 patients, 4.1%), hypertension (3 patients, 6.1%), and other (1 patient). The average of the left ventricular ejection fraction did not decline markedly. No symptomatic left ventricular systolic dysfunction was observed. Conclusions In patients with HER2-positive AMBC, eribulin, pertuzumab, and trastuzumab combination therapy exhibited substantial antitumor activity with an acceptable safety profile. Hence, we have started a randomized phase III study comparing eribulin and a taxane in combination with pertuzumab and trastuzumab for the treatment of HER2-positive AMBC. Trial registration ID: UMIN-CTR: UMIN000012232.
Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones
Authors: Clark Robert D. , Morris Denise N. , Chinigo Gary , Lawless Michael S. , Prudhomme Jacques , Le Roch Karine G. , Lafuente Maria José , Ferrer Santiago , Gamo Francisco Javier , Gadwood Robert , Woltosz Walter S. 
Published: August 2020

AbstractThere is a pressing need to improve the efficiency of drug development, and nowhere is that need more clear than in the case of neglected diseases like malaria. The peculiarities of pyrimidine metabolism in Plasmodium species make inhibition of dihydroorotate dehydrogenase (DHODH) an attractive target for antimalarial drug design. By applying a pair of complementary quantitative structure–activity relationships derived for inhibition of a truncated, soluble form of the enzyme from Plasmodium falciparum (s-PfDHODH) to data from a large-scale phenotypic screen against cultured parasites, we were able to identify a class of antimalarial leads that inhibit the enzyme and abolish parasite growth in blood culture. Novel analogs extending that class were designed and synthesized with a goal of improving potency as well as the general pharmacokinetic and toxicological profiles. Their synthesis also represented an opportunity to prospectively validate our in silico property predictions. The seven analogs synthesized exhibited physicochemical properties in good agreement with prediction, and five of them were more active against P. falciparum growing in blood culture than any of the compounds in the published lead series. The particular analogs prepared did not inhibit s-PfDHODH in vitro, but advanced biological assays indicated that other examples from the class did inhibit intact PfDHODH bound to the mitochondrial membrane. The new analogs, however, killed the parasites by acting through some other, unidentified mechanism 24–48 h before PfDHODH inhibition would be expected to do so.
Comparison between biparietal bipolar and uniparietal bipolar radio frequency ablation techniques in a simultaneous procedural setting
Authors: Matteucci Francesco , Maesen Bart , De Asmundis Carlo , Bidar Elham , Parise Gianmarco , Maessen Jos G. , La Meir Mark , Gelsomino Sandro 
Published: August 2020

Abstract
Purpose
To make an in vitro evaluation of the lesion size and depth produced in two different sets of radio frequency energy bipolar delivery: simultaneous biparietal bipolar (SBB) and simultaneous uniparietal bipolar (SUB).

Methods
Two separate prototypes have been built for our purpose: one to be used in SBB mode and the other to be used SUB mode. Forty left atrium samples were taken from the hearts of freshly slaughtered pigs. They were ablated into a simulator ABLABOX, where blood flow, temperature, and contact force were controlled. After being sliced into a cryotome, the samples were digitalized by a flatbed scanner, and the images were analyzed by a computer morphometric software.

Results
Transmural lesions were achieved in 18/20 samples (90%) in SBB, while SUB showed transmurality in 9/20 samples (45%). Overall maximum diameter (DMAX) resulted larger in SUB than in SBB (2.43 ± 0.30 mm, 1.62 ± 0.14 mm, respectively; p < 0.05): Moreover, maximum epicardial and endocardial diameters (DEPI and DENDO, respectively) were wider in SUB group than SBB group (2.28 ± 0.30 mm, 2.26 ± 0.40 and 1.60 ± 0.14 mm, 1.59 ± 0.15 mm, respectively; p < 0.05). We observed the same tendency in lesion depth: The total area and volume (ATOT and VTOT) were broader in SUB group than in SBB one (581.01 ± 65.38 mm/mm2, 58.10 ± 6.53 mm/mm3 and 521.97 ± 73.05 mm/mm2, 52.19 ± 7.30 mm/mm3. respectively; p < 0.05).

Conclusions
In contrast with the smaller lesion sizes, the biparietal bipolar group showed a higher transmurality rate. These findings may suggest a better drive of the energy flow when compared with SUB lesions.
Is the world a heap of quantum fragments?
Authors: Iaquinto Samuele , Calosi Claudio 
Published: August 2020

AbstractFragmentalism was originally introduced as a new A-theory of time. It was further refined and discussed, and different developments of the original insight have been proposed. In a celebrated paper, Jonathan Simon contends that fragmentalism delivers a new realist account of the quantum state—which he calls conservative realism—according to which: (i) the quantum state is a complete description of a physical system, (ii) the quantum (superposition) state is grounded in its terms, and (iii) the superposition terms are themselves grounded in local goings-on about the system in question. We will argue that fragmentalism, at least along the lines proposed by Simon, does not offer a new, satisfactory realistic account of the quantum state. This raises the question about whether there are some other viable forms of quantum fragmentalism.
A quantum vocal theory of sound
Authors: Rocchesso Davide , Mannone Maria 
Published: August 2020

AbstractConcepts and formalism from acoustics are often used to exemplify quantum mechanics. Conversely, quantum mechanics could be used to achieve a new perspective on acoustics, as shown by Gabor studies. Here, we focus in particular on the study of human voice, considered as a probe to investigate the world of sounds. We present a theoretical framework that is based on observables of vocal production, and on some measurement apparati that can be used both for analysis and synthesis. In analogy to the description of spin states of a particle, the quantum-mechanical formalism is used to describe the relations between the fundamental states associated with phonetic labels such as phonation, turbulence, and supraglottal myoelastic vibrations. The intermingling of these states, and their temporal evolution, can still be interpreted in the Fourier/Gabor plane, and effective extractors can be implemented. The bases for a quantum vocal theory of sound, with implications in sound analysis and design, are presented.
From perception to action using observed actions to learn gestures
Authors: Fuhl Wolfgang 
Published: August 2020

AbstractPervasive computing environments deliver a multitude of possibilities for human–computer interactions. Modern technologies, such as gesture control or speech recognition, allow different devices to be controlled without additional hardware. A drawback of these concepts is that gestures and commands need to be learned. We propose a system that is able to learn actions by observation of the user. To accomplish this, we use a camera and deep learning algorithms in a self-supervised fashion. The user can either train the system directly by showing gestures examples and perform an action, or let the system learn by itself. To evaluate the system, five experiments are carried out. In the first experiment, initial detectors are trained and used to evaluate our training procedure. The following three experiments are used to evaluate the adaption of our system and the applicability to new environments. In the last experiment, the online adaption is evaluated as well as adaption times and intervals are shown.