bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological variables influencing overall survival, recurrence and post-recurrence survival in resected stage I non-small-cell lung cancer
Authors: Wang Chengdi , Wu Yuxuan , Shao Jun , Liu Dan , Li Weimin 
Published: January 2020

Abstract
Background: To investigate clinicopathological variables influencing overall survival, overall recurrence, and post-recurrence survival (PRS) in patients who experienced curative-intent surgical resection of stage I non-small-cell lung cancer (NSCLC).
Methods: We investigated a series of 1,387 patients with stage I NSCLC who underwent surgical resection from 2008 to 2015. The effect clinicopathological factors on death, recurrence, and PRS were evaluated by Kaplan-Meier estimates and cox regression analysis.
Results: Among the 1,387 stage I patients, 301 (21.7%) experienced recurrence. The 5-year cumulative incidence of recurrence (CIR) for all patients was 20.2% and median PRS was 25.5 months. The older age ( P =0.036), p-stage IB ( P =0.001), sublobar resection( P ＜0.001), histology subtype ( P ＜0.001), and lymphovascular invasion (LVI) ( P =0.042) were significantly associated with worse overall survival. Among 301 recurrent patients, univariable analysis indicated that p-stage IB (versus IA) ( P ＜0.001), LVI ( P ＜0.001) and visceral pleural invasion (VPI) ( P ＜0.001) were remarkably correlated with the higher incidence of recurrence. Taking the effect of clinicopathological variables on PRS into consideration, smoking history ( P =0.043), non-adenocarcinoma ( P =0.013), high architectural grade of LUAD ( P =0.019), EGFR wild status ( P =0.002), bone metastasis ( P =0.042) and brain metastasis ( P =0.040) were substantially related with poorer PRS. Multivariate analysis demonstrated that high architectural grade of LUAD (P=0.008), brain metastasis ( P =0.010) and bone metastasis ( P =0.043) were independently associated with PRS.
Conclusion: In patients with resected stage I NSCLC, the older age, p-stage IB (versus IA), sublobar resection, histology subtype, and LVI were significantly associated with worse overall survival. P-stage IB (versus IA), LVI, and VPI were significantly correlated with the higher incidence of recurrence. High architectural grade of LUAD, brain metastasis and bone metastasis were independent risk factors with PRS.
The incidence of collagen-associated adverse events in pediatric population with the use of Fluoroquinolones: a nationwide cohort study in Taiwan
Authors: Yu Pei-Han , Hu Chih-Fen , Liu Jen-Wei , Chung Chi-Hsiang , Chen Yong-Chen , Sun Chien-An , Chien Wu-Chien 
Published: January 2020

Abstract
Background: To evaluate the safety of using fluoroquinolones in pediatric population in Taiwan. Methods : Patients aged 0~18 years old with fluoroquinolones prescriptions ≥5 consecutive days during year 2000 to 2013 were selected from the National Health Insurance Research Database, 4-time case number were selected as controls. We evaluated the patient’s outcome after the use of fluoroquinolones by reviewing a newly diagnosis of the following collagen-associated adverse events by International Classification of Diseases, Ninth Revision, Clinical Modification codes, covering tendons rupture, retinal detachments, gastrointestinal tract perforation, aortic aneurysm or dissection. Results : Of the enrolled patients (n=167,105), collagen-associated adverse effects developed in 85 cases (0.051%) in 6-month tracking, including 0.051% in the fluoroquinolones study cohort (17 in 33,421) and 0.051% (68 in 133,684) in the fluoroquinolones free comparison cohort. The crude hazard ratio for collagen-associated adverse events in the fluoroquinolones group was 0.997 (0.586-1.696; p=0.990). After adjusting for age, sex, catastrophic illness, low-income household, seasons, levels of urbanization, and healthcare, the corrected hazard ratio in 6-month tracking with FQs was 1.330 (95% CI; 0.778-2.276; p=0.255). Conclusions: There is no significant difference of collagen-associated adverse effects between fluoroquinolones group and fluoroquinolones free group from our data. We propose that fluoroquinolones for pediatric population in clinical practice may be not so harmful as previous references reported.
IgG antibody response against Anopheles salivary gland proteins in asymptomatic Plasmodium infections in Narino, Colombia
Authors: Montiel Jehidys , Carbal Luisa Fernanda , Tobón-Castaño Alberto , Vásquez Gissella M. , Fisher Michael L. , Londono Berlin L. 
Published: January 2020

Abstract
Background
The humoral immune response against Anopheles salivary glands proteins in the vertebrate host can reflect the intensity of exposure to Anopheles bites and the risk of Plasmodium infection. In Colombia, the identification of exposure biomarkers is necessary due to the several Anopheles species circulating. The purpose of this study was to evaluate risk of malaria infection by measuring antibody responses against salivary glands extracts from Anopheles (Nyssorhynchus) albimanus and Anopheles (Nys.) darlingi and also against the gSG6-P1 peptide of Anopheles gambiae in people residing in a malaria endemic area in the Colombian Pacific coast.
Methods
Dried blood spots samples were eluted to measure the IgG antibodies against salivary gland extracts of An. albimanusstrains STECLA (STE) and Cartagena (CTG) and An. darlingi and the gSG6-P1 peptide by ELISA in uninfected people and microscopic and submicroscopic Plasmodium carriers from the Colombia Pacific Coast. A multiple linear mixed regression model, Spearman correlation, and Mann-Whitney U-test were used to analyse IgG data.
Results
Significant differences in specific IgG levels were detected between infected and uninfected groups for salivary glands extracts from An. albimanus and for gSG6-P1, also IgG response to CTG and gSG6-P1 peptide were positively associated with the IgG response to Plasmodium falciparum in the mixed model.
Conclusion
The CTG and STE An. albimanus salivary glands extracts are a potential source of new Anopheles salivary biomarkers to identify exposure to the main malaria vector and to calculate risk of disease in the Colombian Pacific coast. Also, the gSG6-P1 peptide has the potential to quantify human exposure to the subgenus Anopheles vectors in the same area.
Assessment of the degree of agreement between the judgment of tracheotomy score and the clinician: a retrospective analysis
Authors: Abe Atsushi , Kurita Kenichi , Ito Yu , Hayashi Hiroki , Umemura Eri , Adachi Moriyasu 
Published: January 2020

Abstract
Background: In oral cancer surgery, the decision to tracheotomize is often determined based on the experience of the surgeon. Sometimes, tracheotomy may be performed for cases that may not necessarily require tracheotomy. For such cases, safety is achieved by airway management, but the patients are exposed to tracheotomy-related complications. Several evaluation methods have been reported to predict the need for selective tracheotomy in patients with oral cancer. In this study, we investigated the competency of clinical scoring systems in identifying patients who require tracheotomy among the oral malignancy cases treated with surgery in our department, and examined the degree of agreement between the surgeon’s decision and the scores of various scoring systems. Methods: This study was conducted on 110 patients with oral cancer who were treated with surgery under general anesthesia in the Department of Oral and Maxillofacial Surgery, Nagoya Ekisaikai Hospital, between January 2007 and April 2018. Among them, 67 patients (44 male and 23 female), who were managed by resection and reconstruction, were retrospectively analyzed. To derive the score, we evaluated the endpoint of these indices from clinical records and images. We divided the patients, based on the Cameron and Gupta scores, into two groups: tracheotomy and no tracheotomy groups, and evaluated the degree of agreement by calculating the κ coefficient. Results: After the assessment, the κ coefficients of the Gupta and Cameron scores were 0.61 (95% CI, 0.4-0.82) and 0.6 (95% CI, 0.38-0.82), respectively. The clinical evaluation of the κ coefficient indicated that the Gupta and Cameron scores agreed substantially. Discussion: These score matched the decision of the surgeon and confirmed that it was able to be applied to the decision of the airway management. However, these values are affected by prevalence. When unilateral total neck dissection and resection of the primary lesion were performed, though it was high-risk, the score was low, and an evaluation contradicted it. Conclusions: In this study, the Cameron and Gupta scores agreed with the decision of the experienced surgeon to some extent, and were confirmed to adapt to the clinical judgment.
Concurrent administration of oxytocin with Foley catheter versus misoprostol for induction of labor: A systematic review
Authors: Aziz Mohamed A. Abdel , Jahanfar Shayeste , Abedi Parvin , Faal Shahla 
Published: January 2020

Abstract
Objectives: Around one- third of pregnancies require labor induction due to issues such as post-term pregnancy, stillbirth, and medical complications. This systematic review aimed to evaluate the effect of concurrent administration of Foley catheter plus oxytocin vs. misoprostol on labor induction. Methods: The search was conducted in April 2019. The following databases were searched: PubMed, SCOPUS, Cochrane Central Register of controlled trials and Web of Science. Primary outcomes included mode of delivery and cesarean section rate. Secondary outcomes were the mean time of induction to delivery and delivery in less than 12 hours from induction. Data were analyzed using RevMan. For binary outcomes, the odds ratio with 95% confidence intervals (CI), and for continuous outcomes, the mean difference (MD) with 95% CI was measured. Results: Four studies were included in this review. The cesarean section and vaginal delivery rate in Foley + oxytocin was not significantly different from misoprostol (OR = 0.95; 95 % CI: 0.70, 1.30) and (OR = 0.92; 95 % CI: 0.66, 1.29) respectively. Foley + oxytocin decreased the mean time of induction to delivery compared to misoprostol (MD = 0.60; 95 % CI: 0.03, 1.16), and increased delivery in less than 12 hours from induction (OR = 2.08; 95 % CI: 1.43, 3.02). Conclusion: Although the rate of cesarean and vaginal delivery was not significant in two groups of Foley catheter + oxytocin and misoprostol, the mean time of induction to delivery reduced and delivery in less than 12 hours from induction increased in the Foley +oxytocin.
Oral rehabilitation with complete implant-supported dental prosthesis: a budget impact analysis from the unified health system perspective
Authors: Probst Livia Fernandes , Cavalcante Denise de Fátima Barros , Vanni Tazio , Silva Erica Tatiane da , Cavalcanti Yuri Wanderley , Pereira Antonio Carlos 
Published: January 2020

Abstract
Background Tooth loss is an important measure of a population's health condition and has a significant impact on people's quality of life. Oral rehabilitation is an important means for functional and social recovery of edentulous patThe aim of the study was to estimate the budget impact of complete implant-supported dental prostheses in the rehabilitation of mandibular edentulism in patients within the context of the Unified Health System (Sistema Único de Saúde – SUS).Methods Treatment with complete implant-supported dentures was compared with the technology most frequently used - Conventional Complete Dental Prosthesis. For analysis we adopted the Methodology proposed by the Methodological Guidelines for Budget Impact Analysis of the Brazilian Network for Health Technology Assessment (REBRATS). Sensitivity analysis was performed per scenarios and a temporal horizon of 5 years was used.Results Implementation of treatment by complete implant-supported dental prostheses would demand an amount of US$ 970,253,019.00 in 5 years in the reference scenario, US$ 545,767,323.40 in the most optimistic scenario, and US$ 1,516,020,342.40 in the worst scenario.Conclusions These results could support the Brazilian managers in planning the Federal budget destined to Medium to High Complexity (treatments), making it possible to disseminate rehabilitative treatment performed with complete implant-supported dentures in SUS, and serve as reference for health systems in other countries.
Humanistic and Economic Burden of Depression and Anxiety among Adults with Migraine: A systematic review
Authors: Alwhaibi Monira 
Published: January 2020

Abstract
Background Depression and anxiety are highly prevalent disabling chronic conditions among adults with migraine. These comorbid conditions are becoming a well-recognized public health problem in many countries due to their humanistic and economic burden.Objectives This review was conducted to assess systematically the humanistic and financial burden of migraine and depression and/or anxiety disorder among adults with migraine.Methods A systematic literature search conducted using MedLine and CINAHL via EBSCO, OVID and Cochrane Database of Systematic Reviews via OVID. Studies evaluating the humanistic burden (disability and Health-related Quality of Life (HRQoL)) and the economic burden and healthcare utilization of comorbid depression and anxiety among adults with migraine that were published in peer-reviewed English language journals from inception until August 2019 were included.Results Of the 957 articles identified, 24 studies were included in the review. HRQoL was measured using generic, and migraine-specific measures. Regarding the humanistic burden, twelve studies reported an association between depression and/or anxiety and lower HRQoL and seven studies reported an association between depression and/or anxiety and higher disability. Regarding the economic burden, only two studies were identified and both found that depression and/or anxiety are associated with higher healthcare expenditures and utilization among adults with migraine.Conclusions These results of this review highlight the substantial impact of depression and/or anxiety on HRQoL, disability, healthcare cost and utilization of medical services for adults with migraine. It is important for healthcare providers to be aware of the negative impact of these illnesses and identify and treat anxiety and depression as treatment may have a potential to improve the health outcomes of patients living with migraine.
Risk factors associated with canine overweightness and obesity in an owner-reported survey
Authors: Perry LeeAnn , Shmalberg Justin William , Tanprasertsuk Jirayu , Massey Dan , Honaker Ryan William , Jha Aashish R 
Published: January 2020

Abstract
Background Overweightness and obesity in dogs are associated with negative health outcomes. A better understanding of risk factors associated with canine weight is fundamental to identifying preventative interventions and treatments. In this cross-sectional study, we used a direct to consumer approach to collect body condition scores (BCS), as well as demographic, diet, and lifestyle data on 4,446 dogs. BCS was assessed by owners using a 9-point system and categorized as ideal (BCS 4-5), overweight (BCS 6), and obese (BCS 7+). Following univariate analyses, a stepwise procedure was used to select variables which were included in multivariate logistic regression models. One model was created to compare ideal to all overweight and obese dogs, and another was created to compare ideal to obese dogs only. We then used Elastic Net selection and XGBoost variable importance measures to validate these results.Results Overall, 1,480 (33%) of dogs were reported to be overweight or obese, of which 356 (8% total) of dogs were reported to be obese. Seven factors were significantly associated with both overweightness/obesity and obesity alone in all three analyses (stepwise, Elastic Net, and XGBoost): diet composition, probiotic supplementation, treat quantity, exercise, age, food motivation level, and pet appetite. Neutering was also associated with overweightness/obesity in all analyses.Conclusions This study recapitulated established risk factors associated with BCS (age, exercise, neutering). Moreover, we elucidated associations between previously examined risk factors and BCS (diet composition, treat consumption, and temperament) and identified a novel factor (probiotic supplementation). Specifically, relative to dogs on fresh food diets, BCS was higher in dogs eating dry food both alone and in combination with other foods. Furthermore, dogs receiving probiotics, but not other forms of supplementation, were more likely to have an ideal BCS. Future studies should corroborate these findings with experimental manipulations.
New Glycine derived peptides bearing benzenesulphonamide as antiplasmodial agent
Authors: Ugwuja Daniel Izuchukwu , Okoro Uchechukwu , Soman Shubhanji , Ibezim Akachukwu , Ugwu David , Soni Rina , Obi Bonaventure , Ezugwu James , Ekoh Ogechi 
Published: January 2020

Abstract
Background : In the tropics, malaria is among the most serious infections disease in developing countries. The discovery of artemesinin antimalarial drug not too long ago was a major breakthrough in effort to combat malaria disease. However, recent reports of resistance even to combination therapy involving artemisinin are very worrisome and have led to search for new chemical agents to sustain the fight against malaria. Carboxamide functionality has been shown as an important pharmacophore in over 25 % of commercial chemotherapeutic agents.
Method : Three benzensulphonamides ( 3a-c ) were prepared from the reaction of appropriate benzensulphonyl chloride ( 1a-c ) and alanine ( 2 ) in aqueous basic medium. Eight tert-butylamino-oxo-ethylcarbamates ( 5a-h ) were also prepared from reacting commercially available boc-glycine( 4 ) and different amines using peptide coupling reagents such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC), 1-hydroxybenzotriazole (HOBt), with triethyl amine and dichloromethane (DCM) as solvents. The target compounds were prepared by reacting compounds ( 3a-c ) with compounds ( 5a-h ) in the presence of coupling reagents. The compounds were characterized and evaluated for their antiplasmodial activity Results : Computed molecular descriptors and assessed biochemical parameters showed that the compounds were drug-like and safe. All the compounds had favourable binding interaction with residues at PABA binding site of homology modeled P. falciparum dihydropteroate synthase and henceforward in vitro and in vivo antiplasmodial activities were evaluated. Compounds 7a-7x showed activity against the P. falciparum (W2 strain) at MIC values ranging from 3.52 to 0.09 µM. Moreover, seven of the compounds ( 7c , 7d , 7i , 7j , 7p , 7r and 7s ) showed better activity than quinine (MIC = 0.72 µM). In addition, 16 of the 24 compounds were found to clear more than 50 percent of P. berghei (NK-65 strain) from the blood of infected mice at 12 post-infection day. The percentages of parasites cleared by 20 mg/kg of the three most effective compounds ( 7g , 7n and 7r ) were 74.98, 74.98 and 74.07 respectively
Conclusion : In coclusion, this class of glycine derived sulfonamides, especially 7r (MIC 0.71 µM), ability to clear 74.07 % of P. berghei from blood of infected mice at 20 mg/kg and interesting pharmacokinetic profile (MW = 430.31 Da, HBA = 7, HBD = 3, log P = 2.56, NRB = 9 and TPSA = 104.37 Å 2 ), could serve as leads in developing new antiplasmodial agent.
Pro-cathepsin D as a diagnostic marker in differentiating malignant pleural effusion from benign pleural effusion: A retrospective cohort study
Authors: Choi Hayoung , Ko Yousang , Lee Chang Youl 
Published: January 2020

Abstract
Background Malignant pleural effusion (MPE) is a common complication of lung cancer and intrathoracic spreading or metastasis of extra-thoracic malignancy. The aim of the present study was to evaluate the levels of pro-cathepsin D from plasma and pleural fluid in patients with MPE and those in patients with benign pleural effusion (BPE) including pleural tuberculosis and parapneumonic effusion.Methods This study included 81 patients with pleural effusion who underwent thoracentesis and pleural biopsy. Pleural fluid and serum were collected as a standard procedure for all individuals at the same time. The level of pro-cathepsin D was measured by the sandwich enzyme-linked immunosorbent assay method.Results Though there were no significant differences in plasma pro-cathepsin D between the two groups, the level of pleural fluid pro-cathepsin D was signiﬁcantly higher in the MPE group than the BPE group (0.651 versus 0.590 pg/mL, P = 0.034) (Table 1). In addition, there were no differences in pleural fluid pro-cathepsin D level according to causative malignancy of MPE. On receiver operating characteristic curve analysis, the optimal discrimination point between the MPE group and BPE group was deﬁned as a cut-off value of 0.5960 pg/mL for pleural fluid pro-cathepsin D (81.0% sensitivity; 53.0% speciﬁcity) and 0.4335 pg/mL for plasma pro-cathepsin D (71.4% sensitivity; 61.7% speciﬁcity).Conclusions We found that the level of pleural fluid pro-cathepsin D was significantly higher in the MPE group than the BPE group. Pro-cathepsin D could be a novel and potential biomarker to discriminate MPE from BPE.
Liver Metastases in Newly Diagnosed Pancreatic Ductal Adenocarcinoma: A Population Based Analysis
Authors: Wu Guoyi , Pan Xiaoben , Wang Baohua , Zhu Xiaolei , Wu Jing , Liu Bo 
Published: January 2020

Abstract
Background Estimates of the incidence and prognosis of developing liver metastases at the pancreatic ductal adenocarcinoma (PDAC) diagnosis are lacking.Methods In this study, we analyzed the association of liver metastases and the PDAC patients outcome. The risk factors associated with liver metastases in PDAC patients were analyzed using multivariable logistic regression analysis. The overall survival (OS) was estimated using Kaplan-Meier curves and log-rank test. Cox regression was performed to identify factors associated with OS.Results Patients with primary PDAC in the tail of the pancreas had a higher incidence of liver metastases (62.2%) than those with PDAC in the head (28.6%). Female gender, younger age, primary PDAC in the body or tail of the pancreas, and larger primary PDAC tumor size were positively associated with the occurrence of liver metastases. The median survival of patients with liver metastases was significantly shorter than that of patients without liver metastases. Older age, unmarried status, primary PDAC in the tail of the pancreas, and tumor size ≥4 cm were risk factors for OS in the liver metastases cohort.Conclusions Population-based estimates of the incidence and prognosis of PDAC with liver metastases may help decide whether diffusion-weighted magnetic resonance imaging should be performed in patients with primary PDAC in the tail or body of the pancreas. The location of primary PDAC should be considered during the diagnosis and treatment of primary PDAC.