bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a time and motion guide to assess the costs of prevention and control interventions for nosocomial infections: A Delphi method among experts
Authors: Tchouaket Nguemeleu Eric , Boivin Sandra , Robins Stephanie , Sia Drissa , Kilpatrick Kelley , Brousseau Sylvain , Dubreuil Bruno , Larouche Catherine , Parisien Natasha 
Published: November 2020

Background
Nosocomial infections place a heavy burden on patients and healthcare providers and impact health care institutions financially. Reducing nosocomial infections requires an integrated program of prevention and control using key clinical best care practices. No instrument currently exists that measures these practices in terms of personnel time and material costs.

Objective
To develop and validate an instrument that would measure nosocomial infection control and prevention best care practice costs, including estimates of human and material resources.

Methods
An evaluation of the literature identified four practices essential for the control of pathogens: hand hygiene, hygiene and sanitation, screening and additional precaution. To reflect time, materials and products used in these practices, our team developed a time and motion guide. Iterations of the guide were assessed in a Delphi technique; content validity was established using the content validity index and reliability was assessed using Kruskall Wallis one-way ANOVA of rank test.

Results
Two rounds of Delphi review were required; 88% of invited experts completed the assessment. The final version of the guide contains eight dimensions: Identification [83 items]; Personnel [5 items]; Additional Precautions [1 item]; Hand Hygiene [2 items]; Personal Protective Equipment [14 items]; Screening [4 items]; Cleaning and Disinfection of Patient Care Equipment [33 items]; and Hygiene and Sanitation [24 items]. The content validity index obtained for all dimensions was acceptable (> 80%). Experts statistically agreed on six of the eight dimensions.

Discussion/Conclusion
This study developed and validated a new instrument based on expert opinion, the time and motion guide, for the systematic assessment of costs relating to the human and material resources used in nosocomial infection prevention and control. This guide will prove useful to measure the intensity of the application of prevention and control measures taken before, during and after outbreak periods or during pandemics such as COVID-19.
Short-term and long-term comparisons of laparoscopy-assisted proximal gastrectomy with esophagogastrostomy by the double-flap technique and laparoscopy-assisted total gastrectomy for proximal gastric cancer
Authors: Tsumura Tomoko , Kuroda Shinji , Nishizaki Masahiko , Kikuchi Satoru , Kakiuchi Yoshihiko , Takata Nobuo , Ito Atene , Watanabe Megumi , Kuwada Kazuya , Kagawa Shunsuke , Fujiwara Toshiyoshi 
Published: November 2020

Background
Although proximal gastrectomy (PG) is a recognized surgical procedure for early proximal gastric cancer, total gastrectomy (TG) is sometimes selected due to concern about severe gastroesophageal reflux. Esophagogastrostomy by the double-flap technique (DFT) is an anti-reflux reconstruction after PG, and its short-term effectiveness has been reported. However, little is known about the long-term effects on nutritional status and quality of life (QOL).

Methods
Gastric cancer patients who underwent laparoscopy-assisted PG (LAPG) with DFT or laparoscopy-assisted TG (LATG) between April 2011 and March 2014 were retrospectively analyzed. Body weight (BW), body mass index (BMI), and prognostic nutritional index (PNI) were reviewed to assess nutritional status, and the Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 was used to assess QOL.

Results
A total of 36 patients (LATG: 17, LAPG: 19) were enrolled. Four of 17 LATG patients (24%) were diagnosed with Stage ≥II after surgery, and half received S-1 adjuvant chemotherapy. BW and PNI were better maintained in LAPG than in LATG patients until 1-year follow-up. Seven of 16 LATG patients (44%) were categorized as “underweight (BMI<18.5 kg/m2)” at 1-year follow-up, compared to three of 18 LAPG patients (17%; p = 0.0836). The PGSAS-45 showed no significant difference in all QOL categories except for decreased BW (p = 0.0132). Multivariate analysis showed that LATG was the only potential risk factor for severe BW loss (odds ratio: 3.03, p = 0.0722).

Conclusions
LAPG with DFT was superior to LATG in postoperative nutritional maintenance, and can be the first option for early proximal gastric cancer.
Cohort profile: The Chikwawa lung health cohort; a population-based observational non-communicable respiratory disease study of adults in Malawi
Authors: Njoroge Martin W. , Rylance Sarah , Nightingale Rebecca , Gordon Stephen , Mortimer Kevin , Burney Peter , Rylance Jamie , Obasi Angela , Niessen Louis , Devereux Graham ,   on behalf of The IMPALA Consortium
Published: November 2020

Purpose
The aim of this article is to provide a detailed description of the Chikwawa lung health cohort which was established in rural Malawi to prospectively determine the prevalence and causes of lung disease amongst the general population of adults living in a low-income rural setting in Sub-Saharan Africa.

Participants
A total of 1481 participants were randomly identified and recruited in 2014 for the baseline study. We collected data on demographic, socio-economic status, respiratory symptoms and potentially relevant exposures such as smoking, household fuels, environmental exposures, occupational history/exposures, dietary intake, healthcare utilization, cost (medication, outpatient visits and inpatient admissions) and productivity losses. Spirometry was performed to assess lung function. At baseline, 56.9% of the participants were female, mean age was 43.8 (SD:17.8) and mean body mass index (BMI) was 21.6 Kg/m2 (SD: 3.46)

Findings to date
The cohort has reported the prevalence of chronic respiratory symptoms (13.6%, 95% confidence interval [CI], 11.9–15.4), spirometric obstruction (8.7%, 95% CI, 7.0–10.7), and spirometric restriction (34.8%, 95% CI, 31.7–38.0). Additionally, an annual decline in forced expiratory volume in one second [FEV1] of 30.9mL/year (95% CI: 21.6 to 40.1) and forced vital capacity [FVC] by 38.3 mL/year (95% CI: 28.5 to 48.1) has been reported.

Future plans
The ongoing phases of follow-up will determine the annual rate of decline in lung function as measured through spirometry and the development of airflow obstruction and restriction, and relate these to morbidity, mortality and economic cost of airflow obstruction and restriction. Population-based mathematical models will be developed driven by the empirical data from the cohort and national population data for Malawi to assess the effects of interventions and programmes to address the lung burden in Malawi. The present follow-up study started in 2019.
No association between the vitamin D-binding protein (DBP) gene polymorphisms (rs7041 and rs4588) and multiple sclerosis and type 1 diabetes mellitus: A meta-analysis
Authors: Zhang Xin , Gao Bai , Xu Bing 
Published: November 2020

Background
The association between polymorphisms in vitamin D-binding protein (DBP) gene and the risk of multiple sclerosis (MS) and type 1 diabetes mellitus (T1DM) has been investigated in many studies, but the studies showed controversial results. The rationale for this meta-analysis was to determine whether DBP polymorphisms increases the risk of MS and T1DM by pooling data.

Methods
Potentially relevant studies were searched using GWAS Catalog, PubMed, Embase, CNKI and WANFANG databases up to November 2019. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were performed to estimate the associations in a fixed-effects or random-effects model.

Results
A total of 13 studies were enrolled in this meta-analysis, including eight studies for MS and five for T1DM. The overall results showed that there was no significant association of DBP rs7041 and rs4588 polymorphisms with the risk of MS and T1DM under any genetic model. Similarly, subgroup analysis by ethnicity revealed that no significant association of rs7041 and rs4588 polymorphisms with the risk of MS and T1DM was observed in white or non-white racial groups.

Conclusions
This meta-analysis provides evidence that DBP rs7041 and rs4588 polymorphisms may not be associated with an increased risk in MS and T1DM. However, these findings need further validation by larger-scale epidemiological studies and genome-wide association studies (GWASs) in different populations.
Effects of COVID-19 lockdown on heart rate variability
Authors: Bourdillon Nicolas , Yazdani Sasan , Schmitt Laurent , Millet Grégoire P. 
Published: November 2020

Introduction
Strict lockdown rules were imposed to the French population from 17 March to 11 May 2020, which may result in limited possibilities of physical activity, modified psychological and health states. This report is focused on HRV parameters kinetics before, during and after this lockdown period.

Methods
95 participants were included in this study (27 women, 68 men, 37 ± 11 years, 176 ± 8 cm, 71 ± 12 kg), who underwent regular orthostatic tests (a 5-minute supine followed by a 5-minute standing recording of heart rate (HR)) on a regular basis before (BSL), during (CFN) and after (RCV) the lockdown. HR, power in low- and high-frequency bands (LF, HF, respectively) and root mean square of the successive differences (RMSSD) were computed for each orthostatic test, and for each position. Subjective well-being was assessed on a 0–10 visual analogic scale (VAS). The participants were split in two groups, those who reported an improved well-being (WB+, increase >2 in VAS score) and those who did not (WB-) during CFN.

Results
Out of the 95 participants, 19 were classified WB+ and 76 WB-. There was an increase in HR and a decrease in RMSSD when measured supine in CFN and RCV, compared to BSL in WB-, whilst opposite results were found in WB+ (i.e. decrease in HR and increase in RMSSD in CFN and RCV; increase in LF and HF in RCV). When pooling data of the three phases, there were significant correlations between VAS and HR, RMSSD, HF, respectively, in the supine position; the higher the VAS score (i.e., subjective well-being), the higher the RMSSD and HF and the lower the HR. In standing position, HRV parameters were not modified during CFN but RMSSD was correlated to VAS.

Conclusion
Our results suggest that the strict COVID-19 lockdown likely had opposite effects on French population as 20% of participants improved parasympathetic activation (RMSSD, HF) and rated positively this period, whilst 80% showed altered responses and deteriorated well-being. The changes in HRV parameters during and after the lockdown period were in line with subjective well-being responses. The observed recordings may reflect a large variety of responses (anxiety, anticipatory stress, change on physical activity…) beyond the scope of the present study. However, these results confirmed the usefulness of HRV as a non-invasive means for monitoring well-being and health in this population.
Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020
Authors: Wang Sijiao , Chen Zhisheng , Lin Yijian , Lin Li , Lin Qunying , Fang Sufang , Shi Yonghong , Zhuang Xibin , Ye Yuming , Wang Ting , Zhang Hongying , Shao Changzhou 
Published: November 2020

Background
Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian Province has been controlled as the number of indigenous cases has not increased since March. We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China.

Methods
In this retrospective, multicenter study, we collected and analyzed the epidemiological, clinical, and laboratory data of all cases confirmed by nucleic acid tests in five designated hospitals in Fujian Province between January 22 and February 27, 2020. All patients were followed up until discharge. COVID-19 severity was classified as mild, moderate, severe, or critical.

Results
Of 199 discharged patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Acute respiratory distress syndrome and respiratory failure occurred in 9 patients (4.5%) and 8 patients (4.0%) respectively. One patient died and the others were cured and discharged with the median hospital stay of 19 days. Old age was negatively correlated with lymphocyte count (r = - 0.296, p < 0.001) and oxygenation index (r = - 0.263, p = 0.001). Bivariate regression analysis revealed that old age (≥ 75 years), hypertension, diabetes, and lymphopenia were correlated with the severity of COVID-19.

Conclusions
Patients in Fujian Province were mostly nonsevere cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). Older age, hypertension, diabetes, and lymphopenia were risk factors for severity of COVID-19.
Age differences in selected measures of physical fitness in young handball players
Authors: Fernandez-Fernandez Jaime , Martinez-Martin Isidoro , Garcia-Tormo Vicente , Garcia-Lopez Juan , Centeno-Esteban Mario , Pereira Lucas A. , Loturco Irineu 
Published: November 2020

Objective
The aims of the present study were: 1) to calculate the change of direction (COD) deficit (using a modified version of the 505 test and 10 m sprint time), and (2) to examine the differences in linear sprint, jump and COD performances, as well as COD deficit, between under-13 (U13) and under-15 (U15) male handball players.

Methods
One hundred and nineteen young male handball players (under-13 [U13; n = 82] and under-15 [U15; n = 37]). Tests included anthropometric measurements, countermovement jump (CMJ), triple leg-hop for distance, linear sprint test (5, 10 and 20 m), and a modified version of the 505 COD test.

Results
Results showed moderate to very large differences (P < 0.05) in age, predicted age at peak height velocity (APHV), distance from PHV (DPHV), height, and body mass between the age categories. Moreover, U15 players demonstrated higher performances in all jump tests and lower sprint times in 10- (ES = 0.84) and 20-m (ES = 0.51) and a higher 505 deficit (ES = 0.38) than the U13 players (P < 0.05). However, no significant differences were observed for the 505 COD test between groups (ES = 0.12; P > 0.05).

Conclusions
Our results suggest that during the transition from pre- to post-puberty, young handball players should focus on transferring their progressive improvements in strength, speed, and power capacities to COD performance.
Diet-Dependent and Diet-Independent Hemorheological Alterations in Celiac Disease: A Case-Control Study
Authors: Szakács Zsolt , Csiszár Beáta , Nagy Mátyás , Farkas Nelli , Kenyeres Péter , Erős Adrienn , Hussain Alizadeh , Márta Katalin , Szentesi Andrea , Tőkés-Füzesi Margit , Berki Tímea , Vincze Áron , Tóth Kálmán , Hegyi Péter , Bajor Judit 
Published: November 2020

INTRODUCTION:
Hemorheology is the study of the flow properties of the blood and its elements, which, together with natural anticoagulants, are important determinants of cardiovascular events. This study aimed to assess hemorheological and natural anticoagulant profiles of patients with celiac disease (CeD) comprehensively.

METHODS:
Our study is a case-control study (registered under ISRCTN49677481) comparing patients with CeD with age- and sex-matched control subjects (1:1). We measured erythrocyte deformability (ED) at high (3–30 Pa) and low shears (0.3–3 Pa), erythrocyte aggregation, whole blood viscosity, plasma viscosity, and natural anticoagulants (protein C, protein S, and antithrombin activity). Adherence to gluten-free diet was estimated through dietary interview and urine gluten immunogenic peptide (urine GIP) detection.

RESULTS:
After matching, we analyzed the data of 100 study participants. ED at high shears was impaired in CeD (P < 0.05 for all shears, confirmed by random forest analysis) independently of findings on CeD-specific serological assessment and urine GIP detection but slightly dependently on dietary adherence (P = 0.025 for 30 Pa shear). ED at low shears seemed to be impaired only in urine GIP+ CeD patients (P < 0.05 for all comparisons with urine GIP− CeD patients and control subjects). All parameters describing erythrocyte aggregation and whole blood viscosity were shifted toward a prothrombotic direction in patients with CeD with poor dietary adherence compared with those with good dietary adherence. Plasma viscosity and activity of natural anticoagulants did not differ across groups.

DISCUSSION:
We observed diet-dependent and diet-independent prothrombotic hemorheological alterations in CeD, which can contribute to the elevated cardiovascular risk. The untoward metabolic changes during gluten-free diet, which can further aggravate hemorheological status, may indicate the implementation of prevention strategies.

JOURNAL/cltg/04.03/01720094-202011000-00009/inline-graphic1/v/2023-10-30T213702Z/r/image-tiff
An Innovation Framework to Integrate Engineering Standards into Industrial Engineering Graduate Curriculum
Authors: Li Hua , Jin Kai 
Published: November 2020

Abstract
The importance of standards is that they provide product manufacturers with clear material, mechanical, and dimensional requirements coupled with specific quality assurance and test methods used to ensure their quality and functionality. Manufacturing-related material standards provide a consensus regarding desired properties between both manufacturers and customers. Moreover, these standards provide analysis methods to measure the properties and leads to standard manufacturing procedures that ensure the quality. To fulfill the need of real-world systems, a curriculum innovation was planned and implemented into the industrial engineering graduate program at Texas A&M University-Kingsville with the aim to integrate manufacturing-related materials and quality management standards into graduate engineering education through innovative course modules and a certificate program. There are four major components in the framework, including (1) course module development on manufacturing-related material standards, (2) course module development on manufacturing-related quality management standards, (3) graduate-level certificate program development, and (4) industrial experience sharing through webinars. ASTM and ISO standards were introduced to graduate students with hands-on experiences on applying standards to real-world case studies. It creates a systematic framework to strengthen graduate students’ education and learning about manufacturing-related materials and quality management standards and standardization. Student surveys were used to collect their feedback, which show very positive impact on the students’ knowledge and interests in standards and standardization.
Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics
Authors: Molino Diana , Pila‐Castellanos Irene , Marjault Henri‐Baptiste , Dias Amoedo Nivea , Kopp Katja , Rochin Leila , Karmi Ola , Sohn Yang‐Sung , Lines Laetitia , Hamaï Ahmed , Joly Stéphane , Radreau Pauline , Vonderscher Jacky , Codogno Patrice , Giordano Francesca , Machin Peter , Rossignol Rodrigue , Meldrum Eric , Arnoult Damien , Ruggieri Alessia , Nechushtai Rachel , de Chassey Benoit , Morel Etienne 
Published: November 2020

AbstractSeveral human pathologies including neurological, cardiac, infectious, cancerous, and metabolic diseases have been associated with altered mitochondria morphodynamics. Here, we identify a small organic molecule, which we named Mito‐C. Mito‐C is targeted to mitochondria and rapidly provokes mitochondrial network fragmentation. Biochemical analyses reveal that Mito‐C is a member of a new class of heterocyclic compounds that target the NEET protein family, previously reported to regulate mitochondrial iron and ROS homeostasis. One of the NEET proteins, NAF‐1, is identified as an important regulator of mitochondria morphodynamics that facilitates recruitment of DRP1 to the ER–mitochondria interface. Consistent with the observation that certain viruses modulate mitochondrial morphogenesis as a necessary part of their replication cycle, Mito‐C counteracts dengue virus‐induced mitochondrial network hyperfusion and represses viral replication. The newly identified chemical class including Mito‐C is of therapeutic relevance for pathologies where altered mitochondria dynamics is part of disease etiology and NEET proteins are highlighted as important therapeutic targets in anti‐viral research.
Down Argentine Way: los remakes de películas argentinas en Hollywood en los años cuarenta
Authors: Kelly Hopfenblatt Alejandro 
Published: November 2020

El creciente acceso a archivos internacionales y el fortalecimiento de redes globales han llevado en los últimos años a una reconsideración de numerosos preceptos sobre los cuales se ha basado la historiografía del cine. Uno de los campos fundamentales de esta renovación ha sido el de los cines nacionales, donde las perspectivas comparadas y trasnacionales han desplazado la mirada hacia las dinámicas globales y a los canales de circulación en que estas se insertaron.
El estudio de los remakes transnacionales configura un terreno de gran riqueza para esta renovación ya que presenta la posibilidad de entrelazar prácticas industriales y comerciales, estrategias narrativas y transformaciones geopolíticas. En lo que respecta al período clásico, la preeminencia de Hollywood como nodo central de gran cantidad de transposiciones de textos internacionales hace que sea un foco ineludible al plantear investigaciones sobre estos films.
Entre la multiplicidad de países que se involucraron en la práctica del remake, un caso poco considerado es el de Argentina, que, a lo largo de los años cuarenta, tuvo dos películas propias que fueron adaptadas por el cine estadounidense: Los martes, orquídeas (Francisco Mugica, 1941) y Romance musical (Ernesto Arancibia, 1947), que se convirtieron en You Were Never Lovelier (Bailando nace el amor, William A. Seiter, 1942) y Romance on the High Seas (Romance en alta mar, Michael Curtiz, 1948) respectivamente. Ambas producciones de Hollywood presentaron comedias románticas insertas en films musicales ambientados en América Latina.
El estudio comparado de los procesos que llevaron a la producción de los dos casos y las formas en que las cintas estadounidenses representaron escenarios y personajes latinos propone interrogantes que permiten complejizar y ahondar en aspectos novedosos de las políticas de Estados Unidos hacia Latinoamérica, las cambiantes relaciones del cine argentino con Hollywood y la tensión entre los imaginarios latinos y las imágenes cosmopolitas.