bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Implementation of Sort, Set in Order, Shine, Standardize, and Sustain as Occupational Accident Preventions at PT X
Authors: Radityo Bayu Adi 
Published: February 2020

Introduction: The implementation of qualified sort, set in order, shine, standardize, and sustain (5S) is a significant factor to prevent the occurrence of occupational accidents in companies with a high-risk level of occupational accidents, such as being exposed to falling objects or tripped with objects, especially in departments that handle goods or materials. This research aims to identify the enactment of 5S as occupational accidents preventions in the logistic department at PT. X. Metods: This research is descriptive-analytic research which describes the company policy regarding the employment of 5S and the characteristics of the workers in the logistic department at PT. X. Moreover, this research also intends to analyze the strength of the relationship between the workers’ characteristics based on the correlation coefficient value by using the cross-sectional approach. The data is in the form of secondary data obtained by using questionnaires and interview. Results: It has been noticed that there is a qualified policy regarding the implementation of 5R in the form of technical instructions and the SOP of the company that has been well-enacted. Majority of the workers in the logistic department at PT. X is between 15-30 years old with high school educational attainment and has been serving in the company for <6 years. It is also perceived that all workers in the logistic department have a good 5S understanding level and good attitudes toward the implementation of 5R. However, there is a difference in the direction of the relationship of the variables analyzed; one is a negative relationship while the other is a positive relationship. Conclusion: It can be affirmed that PT. X has implemented 5S in a good way, seen from the understanding level of the workers regarding 5S or the attitude of the workers in implementing 5S, particularly in the logistic department. This is also proven by the company policy on the enactment of 5S that has been well-carried out. Keywords: 5S implementation, logistic, occupational accidents
Factors Related to Behavior of Using Personal Protective Equipment on Filling Lithos Workers
Authors: Pangihutan Siregar Reymond Sahala 
Published: February 2020

Introduction: Every workplace has risks and risks to the safety and health of workers. Personal Protective Equipment (PPE) as the last control or last effort to control risk in workplace. Using personal protective equipment is influenced by a person's behavior which consists of three factors namely predisposing factors, enabling factors and driving factors. The purpose of this study was to analyze factors related to the behavior of using PPE on workers in the filling lithos process PT. Pertamina Lubricants Production Unit Gresik. Metods: This study was an observational analytic study, using a cross sectional research design. The research sample was 41 people, taken randomly using simple random sampling. Data collection includes age, education, years of service, knowledge, motivational attitudes of PPE availability, supervision and regulations regarding PPE. The data analysis used in this study is Spearman's correlation. Results: Showed that there was a relationship between age factors (p = 0.004) and the behavior of PPE use while other factors were knowledge (p = 0.338), motivation (p = 0.137), availability of PPE, regulations on PPE (p = 0.624) with no association behavior of using PPE. Most samples behave disobediently using PPE. Conclusion:Age has a relationship with my personal use of personal protective equipment and most of the workers behave disobedient using personal protective equipment. Keywords: behavior, filling lithos workers, personal protective equipment
Hyperplasia of Wistar rat tongue mucosa due to exposure to cigarette side-stream smoke
Authors: Ayuningtyas Nurina Febriyanti , Mahardika Grahania Octaviono , Soebadi Bagus , Permadiati Adiastuti Endah , Winias Saka , Hendarti Hening Tuti , Zain Rosnah Binti 
Published: February 2020

Background: Hyperplasia, a condition whereby an excessive number of cells are produced due to their uncontrolled division, represents a common symptom of carcinogenesis. Cancer is a physical manifestation of cell malignancy resulting from abnormal proliferation. Globally, oral cancer currently constitutes the sixth largest lethal form of the condition. The most common etiology of oral cancer is tobacco of which cigarettes are the most popular related product. The health risks associated with cigarette smoke not only affect active smokers but also individuals who ingest it passively. Sidestream smoke comes from the lighted end of a burning tobacco product such as a cigarette, pipe or cigar and contains nicotine and many harmful cancer-causing chemicals. Inhaling sidestream smoke increases the risk of lung and other types of cancer. Purpose: The purpose of this study was to understand how sidestream cigarette smoke initiates precancerous changes, in this case hyperplasia, in the oral mucosa epithelium of Wistar rats. Methods: The subjects were divided into three groups, a 4-week treatment group (P1), an 8-week treatment group (P2), and a control group (K), each consisting of ten subjects. The subjects were exposed to a daily two-cigarette dose of smoke. The experiment used a post-test only control group design. All samples were sacrificed during the fourth and eighth weeks. Haematoxylin-eosin staining was performed on the tongues of the Wistar rats to establish the presence of hyperplasia. Data was analyzed using a one-way ANOVA test. Results: After the Wistar rats had been exposed to cigarette smoke, an increased degree of epithelial cell proliferation (hyperplasia) showed a significant difference with a p-value <0.05 during the eighth week. Conclusion: Exposure to cigarette sidestream smoke induces increased epithelial cell proliferation (hyperplasia) in Wistar rats.
Analisis Kegiatan Public Relation Untuk Membangun Brand Awerness di PT Victory International Futures
Authors: Lailiyah Nur 
Published: February 2020

Perusahaan yang bergerak dalam bidang investasi pada produk indeks futures, forex dan logam mulia saat ini sangat banyak sekali macamnya,sehingga dalam kondisi yang seperti ini mengakibatkan banyak persaingan diantara perusahaan-perusahaan, mereka menciptakan brand yang kuat agar bisa dikenal secara luas di masyrakat. Dlam hal tersebut maka Public Relatioan memiliki peran yang sangat penting bagi perusahaan untuk meningkatkan Brand Awarness. Fokus pada penelitian ini yaitu Peran kegiatan Public Relation dalam meningkatkan kesadaran mereka di PT. Victoria International Future. Metode penelitian ini adalah dengan pendekatan kualitatif. Kegiatan Public Relation dapat meningkatkan Brand Awarness bagi perusahaan dan memiliki pengaruh yang positif yang dapat menguntungkan perusahaan. PT Victoria International Futures mampu memberikan pelayan-pelayanan yang baik bagi customernya mapupun masyarakat yang belum menjadi customernya dan selalu membangun hubungan baik dengan mereka, sehingga menjadikannya perusahaan yang unggul
Pengaruh Citra Merek, Harga Dan Kualitas Produk Terhadap Keputusan Pembelian (Studi Kasus Pada Konsumen Mie Endess Di Bangkalan)
Authors: Amalia Nur 
Published: February 2020

Penelitian ini bertujuan untuk mengetahui pengaruh citra merek dan harga terhadap proses keputusan pembelian mie endess yang terletak di JL. HOS. Cokroaminoto No. 72, Rw.05, Pangeranan, Kec.Bangkalan, Kabupaten Bangkalan, Jawa Timur 69115. Sedangkan metode penelitian yang digunakan adalah pendekatan deskriptif kualitatif. Jenis data adalah data sekunder. Metode pengumpulan data menggunakan perpustakaan penelitian atau pengumpulan bahan yang diambil dari penelitian terkait perpustakaan penelitian dan metode analisis data menggunakan reduksi data. Hasil penelitian ini menunjukan bahwa: Citar merek terhadap keputusan pembelian mie endess berpengaruh signifikan, harga terhadap keputusan pembelian mie endess berpengaruh signifikan.
An integrated metagenomics and metabolomics approach implicates the microbiome-gut-brain-axis in the pathogenesis of Huntington’s disease transgenic mice
Authors: Kong Geraldine , Ellul Susan , Narayana Vinod , Kanojia Komal , Ha Harvey Tran Thai , Li Shanshan , Renoir Thibault , Cao Kim-Anh Le , Hannan Anthony 
Published: February 2020

Abstract
Background: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder with onset and severity of symptoms influenced by various environmental factors. Recent discoveries have highlighted the importance of the gastrointestinal microbiome in mediating the bidirectional communication between the central and enteric nervous system via circulating factors. Using shotgun sequencing, we investigated the gut microbiome composition in the R6/1 transgenic mouse model of HD from 4 to 12 weeks of age (early adolescent through to adult stages). Targeted metabolomics was also performed on the blood plasma of these mice (n=9 per group) at 12 weeks of age to investigate potential effects of gut dysbiosis on the plasma metabolome profile. The short-chain fatty acid (SCFA) concentrations in the plasma were validated using LCMS. Results: Beta diversity differed between HD mice compared to their WT littermates at 12 weeks of age, suggesting that gut dysbiosis occurs prior to overt motor symptoms. Modelled time profiles of each species, KEGG Orthologs and bacterial genes, revealed heightened volatility in the HD mice, indicating potential early effects of HD mutation in the gut prior to significant cognitive and motor dysfunction. In addition to gut dysbiosis at 12 weeks of age, we also found functional differences between the WT and HD mice. The butanoate metabolism pathway, which leads to the production of the protective short-chain fatty acid, butyrate, was increased in the gut. However, the plasma concentration of butyrate and propionate were both decreased in the HD mice, as determined by the SCFA validation. The concentrations of ATP were increased by over 4-fold in the HD plasma, which was contrary to expectations. The statistical integration of the metagenomics and metabolomics unraveled several Bacteroides species that were positively correlated with butyrate levels, and negatively correlated with ATP and pipecolic acid in the plasma. Blautia producta and Prevotella scopos were found to be negatively correlated with the butyrate and ATP respectively. Conclusions: Our study has revealed a previously unknown relationship between the gut bacteria and plasma metabolome, suggesting the potential role of gut in modulating the pathogenesis of HD via specific altered plasma metabolites which mediate gut-brain signalling.
Predictive value of neutrophil-to-lymphocyte ratio in diagnosis of early prostate cancer among men who underwent Robotic transperineal prostate biopsy
Authors: Jingzeng Du , Lim Ee Jean , Huang Hong Hong Hong , Lau Kam On Weber Kam On 
Published: February 2020

Abstract
Background

NLR is known to have prognostic value for metastatic prostate cancer (PCa). However for early PCa due to lack of systemic response; the role of NLR is not conclusive. In this study we aim to evaluate the predictive value of NLR for early clinical PCa in patients who underwent robotic transperineal prostate biopsy (RTPB).

Methods

Patients who underwent RTPB under general anesthesia (GA), at the Department of Urology, Singapore General Hospital between Sep 2006 and Feb 2016 were retrospectively reviewed. Exclusion criteria includes: 1. Patients with missing value of PSA NLR 2. Patients who underwent biopsy for non-diagnostic purposes. 3. Patients with chronic inflammation or high grade prostatic intraepithelial neoplasia. Patients who had more than one biopsies and only the last histology results were included in this study.

NLR was calculated for all patients using Complete blood count that was done as pre-admission test before GA within 4 weeks before operation. NLR values were compared between PCa; clinical significant PCa and benign group. Patients were divided further into different groups according to PSA level for subgroup analysis.

Results

A total 652 patients who underwent RTPB for diagnostic purpose with valid pre-procedure PSA level were included in this study. There were total 409 (62.7%) benign histology and 243 (37.3%) PCa cases. Median NLR in the benign histology group and PCa group were 2.00 and 1.99. There was no statistically significant (P=0.29).

In the subgroups analysis, there were also no significant difference of median NLR value in clinical significant cancer group (defined as Gleason 3 + 4 and above) when compared to benign group (NLR 2.00 vs. 2.01, P=0.41) as well as in prostate cancer group and benign group according to different pre-biopsy PSA levels (PSA < 4, 4-10, 10-20 and > 20 ug/L), respectively. (P>0.05). NLR is not a significant predictor for Gleason grade group and D’Amico risk stratification group. (P>0.05)

Conclusion

There were no statistical significant difference of NLR between benign and prostate cancer group as a whole or in the subgroup analyses for patients who underwent RTPB. NLR may have a limited role in predicting early prostate cancer.
Anti-viral effect of Indigoferra gerardiana on core protein of HCV and clinical significance of serum markers in chronic HCV genotype 3a patients in district Peshawar
Authors: Mumtaz Shahina , Ahmed Jawad , Tariq Shafiq Ahmad , Iqbal Waheed , Siraj Sami , Asghar Muhammad , Sarwar Tahir , Rehman Noor 
Published: February 2020

Abstract
Background/aim: Hepatitis C virus (HCV) disease is a health challenge due resistance cases globally. Many plant-derived natural compounds have demonstrated antiviral effects. These plants can provide an alternative way to new antiviral. Core protein of HCV has ability to interact with a wide range of viral and cellular proteins, including proto-oncogenes. Materials and Methods: In this cross-sectional study, total of 421 Hepatitis C Virus (HCV) positive patients were subjected by Polymerase Chain Reaction (PCR). The correlation of genotype with continuous and categorical variables was analyzed. Furthermore, antiviral activity of indigoferra gerardiana (IG) was tested against core protein of HCV. The amplified complete core protein of HCV genotype 3a was sequenced and cloned. IG was extracted and screened against core protein of HCV 3a genotype in cell line. Results: Genotype 3a was the common genotype type of HCV (n=363, 86%). Significant differences were observed in viral load among 3a genotype of HCV (< P 0.05). Frequently detected age group was 21-40 (59.4%) Sex and age were statistically associated with HCV infection (49% males and 37% in females). The results of RT-PCR demonstrated that methanolic extract of IG showed 57% reduction of infecting cells. Conclusions: Methanolic extract of IG showed good antiviral activity i.e. 57% reduction of infecting cells.
Spatio-temporal Clusters of Health Workforce Distribution in Sichuan Province, China: a county-level analysis
Authors: Zhang Ning , Ning Wei , Xie Tao , Liu Jinlin , Zhu Bin , He Rongxin , Wang Xue , Mao Ying 
Published: February 2020

Abstract
Background The health workforce is a key determinant in achieving health equity. As a southwestern province of China, Sichuan confronted with the geographical variation of health workforce in recent years. The misdistribution of health workforce in Sichuan is severe for its complex terrain, uneven population distribution and huge economic differences. The study of Sichuan province is of great significance to other regions of China. Methods This study applied time-series analysis, spatial autocorrelation and space-time scan analysis to explore and visualize the spatial changing patterns of different types of health workforce (health technicians, licensed doctors, registered nurses, pharmacists, technologists, and intern) at the municipal and county level in Sichuan. Results The box plots displayed the temporal trend of health workforce from 2009 to 2018 via the county-level data. All types of health workforce were in rising generally especially the registered nurses. The space-time analysis and Global Moran' I revealed the distinctive geographical clusters among all the counties. The local Moran' I detected that HH clusters mainly in the capital and some rich places of Sichuan, while some mountain areas in eastern Sichuan displayed LL clusters. Four main findings should be paid attention to the whole health workforce of Sichuan province had an upward trend. Comparing with other provinces, the growth rate also was in a high rank; the areas with the scarcest resources were eastern place, including areas of Tsinling Mountains, Yunnan-Guizhou Plateau, Hengduan Mountains and the transition zone of mountains and basins; misdistribution of health workforce had two levels, among the province and cities; the Qinghai Tibet Plateau has enough intern while being short of other health technicians. Conclusions The policies makers should pay more attention to the eastern Sichuan. As to the intern-related policies, the primary health tasks did not achieve, Qinghai Tibet Plateau areas needed to find practical ways to attract the interns
Immune status of children with complications of BCG/BCG-M vaccination
Authors: Sevostyanova T. A. , Аksenova V. A. , Kudlay D. A. 
Published: February 2020

The objective of the study: to analyze certain parameters of immune status in children with complications after BCG/BCG-M vaccination.Subjects and methods. The immune status parameters were tested in 24 children who developed complications after TB vaccination such as BCG-ostitis, BCG-lymphadenitis. Lymphocyte population was assessed using flow cytofluorometry by Cytomics FC 500 (Bekman Coulter).The serum level of immunoglobulins IgG, IgA, IgM was tested by immunodiffusion in Mancini agar. The leukocyte phagocytic activity was tested using flow cytofluorometry (Cytofluorimeter Cytomics FC 500) with FITC-labeled staphylococcus.Results. Of the 24 children with BCG lymphadenitis or BCG ostitis, 22 (92%; 95% CI 73-99%) had abnormality in immune status.Of the 24 children, 7 had low CD3+count, while 9 had an elevated level of CD3+. The level of СD4+was low in 4 children and elevated in 15 pediatric patients. CD8+count was low in 21 children (88%; 95% CI 72-97%). 11 children had low СD16+number, and it was elevated in 2 children. In 10 children, low level of СD16+was combined with low level of CD8+. 10 children had low СD19+number, and it was elevated in 4 children. The leukocyte phagocytic index drastically decreased (down to 37%) only in 1 child, and in 23 children, it varied from 60 to 90%.IgG level was low in 13 (54%), and elevated in 2 (8%) children. IgA level was low in 6 (25%), and it was not detected at all in 8 (33.3%) children. IgM level was elevated in 4/24 (17%) children, while it was low in 1/24 (4%). In 8 children with no IgA detected, the IgG level was low in 5 of them, 3 had a normal level, and IgM level was elevated in 2 children, 6 children had a normal level of IgM. With IgA completely absent, 1 child had the normal level of IgG and IgM.
Alpha-gal syndrome: Implications for cardiovascular disease
Authors: Bianchi John , Walters Anneke , Fitch Zachary W , Turek Joseph W 
Published: February 2020

Alpha-gal syndrome (AGS) refers to a potentially life-threatening allergy to the molecule galactose-α1,3-galactose (gal), which is expressed on most mammalian tissues but, importantly, is not expressed by humans. This syndrome can manifest as an allergic reaction to mammalian meat products, but other sources of mammalian tissue can also provoke an immune response, including injectable and implantable medical products. This syndrome has been linked to coronary atherosclerosis, and medical products that express gal are routinely used in cardiology and cardiac surgery. This article seeks to discuss potential implications of alpha syndrome as it relates to cardiovascular health and to heighten awareness in the cardiovascular community about this emerging public health issue.
Frequency of Neck Pain Among Female Medical Students in a Medical University of Karachi
Authors: Aijaz Saba , Shahzad Ambreen , Fahim Muhammad Faisal , Ahmed Aisha , Asghar Urooj , Mukhtar Muntaha 
Published: February 2020

Background:
Among all the Musculoskeletal Pain (MSP), the most commonly reported MSP among the undergraduate medical students is the neck pain. As the
students study for long hours sitting in front of the computers, use incorrect postures while using the computers, mobile phones, reading, etc. The
females face neck problems due to increase stress in their daily life. Our study aims to find out how prevalent is the neck pain among female
medical students in a Medical University of Karachi.

Methodology:
The study conducted was a cross-sectional survey with a study duration of 4 months i.e. from January, 2018 till April, 2018. A non-probability
purposive sampling, conducted among the female undergraduate students of Doctor of Physiotherapy (DPT), Bachelor of Dental Surgery (BDS),
Bachelor of Medicine and Bachelor of Surgery (MBBS) and Doctor of Pharmacy (Pharm-D) studying in DOW University of Health Science, Ojha
campus Karachi. The estimated sample size was 400 including female undergraduate medical students of MBBS, BDS, Pharm-D and DPT of
DOW University, Ojha campus. Male medical students and students other than DOW University, Ojha campus were not included in this study.
Data was analyzed through SPSS version 16.0. Pearson Chi-Square test was used to see the association between neck pain and different physical
parameters of the Neck Disability Index. P-value less than 0.05 was considered significant.

Results:
The results showed that out of 400 female medical students 301 students were having neck pain among which 24.8% of students reported no
disability, 36.5% reported mild disability, 9.5% reported severe disability, and 4.5% reported complete disability.

Conclusion:
It was concluded that the majority of the female medical students were having neck pain with mild disability due to the presence of neck pain.