bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient experiences with hypertrophic cardiomyopathy: a conceptual model of symptoms and impacts on quality of life
Authors: Zaiser Erica , Sehnert Amy J. , Duenas Ashley , Saberi Sara , Brookes Ella , Reaney Matthew 
Published: December 2020

Abstract
Background
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder defined by left ventricular hypertrophy that cannot be explained by another cardiac or systemic disease. There is a general lack of knowledge about patients’ perspectives on the symptoms and day-to-day limitations they experience as a result of HCM. We therefore sought an in-depth understanding of patients’ experiences of obstructive (oHCM) and nonobstructive (nHCM) forms of the disease, including symptoms and their quality of life impacts, and to develop a conceptual model to capture them.

Methods
Development of the HCM conceptual model involved a web-based survey to capture patients’ insights, a targeted literature review (which included relevant guidelines and patient advocacy websites), one-to-one interviews with clinical experts, and one-to-one qualitative concept elicitation interviews with patients. Key symptoms and their impacts most important to patients’ experiences were identified and used to develop a conceptual model of the patient experience with HCM.

Results
The HCM symptoms reported by patient interviewees (n = 27) were largely consistent with findings from the patient web survey (n = 444), literature review, and interviews with three expert clinicians. The symptoms most commonly reported in patient interviews included tiredness (89%), shortness of breath (89%), shortness of breath with physical activity (89%), and dizziness/light-headedness (89%). Other symptoms commonly reported included chest pain (angina) (70%), chest pain (angina) with physical exertion (70%), and palpitations (fluttering or rapid heartbeat) (81%). The most commonly reported impacts of HCM symptoms on patients’ lives included limitations to physical activities (78%), emotional impacts, including feeling anxious or depressed (78%), and impacts on work (63%). Symptoms and impacts were similar for both oHCM and nHCM.

Conclusions
A conceptual model was developed, which identifies the core symptoms that patients with oHCM and nHCM reported as most frequent and most important: shortness of breath, palpitations, fatigue/tiredness, dizziness/light-headedness, and chest pain, as well as the impacts those symptoms have on patients’ lives. This HCM conceptual model reflecting patients’ experiences and perspectives was used in the development of a patient-reported outcomes instrument for use in clinical trials and it may also help inform the clinical management of HCM.
Comparative analysis of immune related genes between domestic pig and germ-free minipig
Authors: Lee Ju Young , Kim Sang Eun , Lee Hoon Taek , Hwang Jeong Ho 
Published: December 2020

AbstractRecently, minipig has been considered as an animal model that is appropriate for human disease model to study toxicology, pharmacology, and xenotransplantation. Nevertheless, minipigs are bred in various environment according to their use. Here, we suggest that minipigs used for research should be bred in well-controlled facility, comparing immune status of pigs raised in different breeding environment. DNA microarray was performed with ear skin and placenta of Landrace domestic pigs (DPs) and Minnesota germ-free minipigs (GPs). Their immune transcriptome was analyzed by gene ontology (GO) annotation database, based on criteria of |log2 fold change| ≥1 with P ≤ 0.05. As a result, we found that immune related genes in the ear skin of DPs were highly activated, compared to GPs. On the other hand, no significant s were found in the placenta. Quantitative real-time PCR (qRT-PCR) was performed in five candidate immune genes. Their fold changes were consistent with the results from DNA microarray (P ≤ 0.05). In conclusion, we experimentally proved that porcine immune system was affected by different breeding environment, suggesting the importance of controlling microbes in animal room for the qualified research.
Emotional and behavioral problems of 9–18-year-old girls and its relationship to menarche age
Authors: Tayebi Naeimeh , Yektatalab Shahrzad , Akbarzadeh Marzieh 
Published: December 2020

AbstractBackgroundAdolescence is associated with rapid changes in behavioral patterns which affect the functioning of the person in adulthood. The purpose of this research was to study the emotional and behavioral problems of 9–18-year-old girls and their relationship to menarche age. This cross-sectional study was done on girls aged 9–18 years old in Shiraz city. A cluster sampling method was used to select about 2000 students in 2015. Then, a questionnaire including demographic characteristics and strengths and difficulties (SDQ) was completed for each of them. The SPSS software was used to analyze the collected data via descriptive statistics and chi-square tests.ResultsAmong the 2000 tested samples, the highest mean and standard deviation (4.2 ± 2.25) were related to emotional symptoms. Most of them (960 individuals = 48%) scored abnormally. The mean and standard deviation was 15.61 ± 5.89, and the highest value was 33. The highest mean and standard deviation (16.69 ± 5.4) ranged from 17 to 18 years old in 289 subjects. There was a significant relationship between the age of menarche and emotional and behavioral problems (p= 0.001). Most individuals (638 subjects) (46%) had abnormal emotional and behavioral problems in the menarche age of 11–12 years old.ConclusionEmotional symptoms were the most common emotional-behavioral problems of adolescents. There was a significant relationship between the menarche age and emotional and behavioral problems. It is necessary to be familiar with the problems of adolescent girls during adolescence and the way to deal with their problems.
Internal jugular vein rupture after oncologic resections in the head and neck
Authors: Eltelety Ahmad M. , Nassar Ahmed A. , El Batawi Ahmed M. , Ibrahim Sherif G. 
Published: December 2020

AbstractBackgroundInternal jugular vein (IJV) blowout after major oncologic resections in the head and neck is a rare fatal yet preventable complication. The condition is unregistered sufficiently in the literature.ResultsThe records of patients who underwent oncologic neck surgery were retrospectively reviewed. The study included records between January 2014 and November 2019 at Kasr Al Ainy Educational Hospital. 275 patients underwent cervical ablative procedures. Ten patients developed IJV blowout. Six patients were saved. Four patients had diabetes mellitus with postoperative wound infection and dehiscence. Three patients were given primary radiotherapy; two of them developed flap necrosis. Eight patients acquired pharyngocutaneous fistula (PCF). Regional flap coverage was done in three patients. Sentinel hemorrhage occurred in all patients.ConclusionsIJV blowout is a rare potentially life-threatening complication usually preceded by sentinel hemorrhage. The condition is essentially preventable by the prompt and structured response.
Evaluation of the effectiveness of the use of free diced cartilage in dorsal and tip nasal rhinoplasty
Authors: Shafik Amr Gouda , Mohamed Mohamed Naguib , Hassan Hassan Mohamed 
Published: December 2020

Abstract
Background
Rhinoplasty is considered one of the most challenging operations in the plastic surgery. Esthetic or functional reshaping purposes of the nose can be stressing for both surgeon and patient. Different types of graft materials have been used to perform augmentation rhinoplasty. Free diced cartilage (FDC) was recently established in dorsal nasal rhinoplasty for better handling of irregularities as well as contour deficits of dorsal nasal outcomes. The main purpose of the present study is to assess the effectiveness of the use of FDC in dorsal nasal and nasal tip rhinoplasty and evaluation of its advantages and disadvantages using the validated Nasal Obstruction Symptom Evaluation (NOSE) scale and the Rhinoplasty Outcome Evaluation (ROE) questionnaire to assess nasal obstruction and patient satisfaction.

Results
This prospective study was conducted between March 2018 and December 2019, 20 patients were included and planned for rhinoplasty using FDC to camouflage dorsal and nasal tip deformities. All patients (11males and 9 females) underwent open rhinoplasty through inverted v columellar incision, taken FDC from nasal septum. A statistical significant difference between pre- and post-operative NOSE scores was found (P < 0.001). Post-operative rhinoplasty outcome evaluation scores ranged from 45 to 100 with mean ± SD (83.15 ± 13.22). Excellent satisfaction was the most noted in 17 patients (85%), while 2 patients (10%) reported good satisfaction and 1 patient (5%) with acceptable satisfaction.

Conclusion
It was found that the FDC technique is an effective method for camouflage and augmentation of nasal dorsum as well as nasal tip in reconstructive and esthetic rhinosurgery for either primary or secondary rhinoplasty.
Postoperative audiovestibular assessment of obstructive sleep apnea patients
Authors: Kouzo Hesham Saad , Talaat Mohamed Aziz Mohamed , Bahgat Ahmed Yassin , Zamel Hazem Ahmed Mousa , Eldeeb Mirhan Khamis 
Published: December 2020

Abstract
Background
In obstructive sleep apnea syndrome, the impact of hypoxia on different body systems is of utmost importance. Brainstem is greatly sensitive to the effects of hypoxia including auditory and vestibular nuclei. Our aim in the current study is to evaluate hypoxic effect of OSAS on the audiovestibular system using auditory brainstem response, cervical vestibular evoked myogenic potential, and video nystagmography and to determine whether this effect is reversible postoperatively.

Results
In OSAS patients, the mean absolute and interpeak latencies of ABR were significantly prolonged compared to controls and remained so postoperatively. No statistically significant difference between pre- and postoperative values was found. The differences in the mean latencies of P1 and N1 of the cVEMP responses between the two groups were insignificant. However, there was a significant difference in P1N1 amplitude. On the other hand, the difference in the mean amplitude of the P1N1 wave in the study group postoperatively was not significant. The VNG results included bilateral canal paresis in four, unilateral in two, and spontaneous nystagmus in two patients. Also, two patients showed pursuit abnormality and two had saccadic abnormality which did not improve postoperatively.

Conclusions
Patients with moderate to severe OSAS experience both auditory and vestibular deficits which do not reverse 3 months after corrective surgery.
Social, cultural and community engagement and mental health: cross-disciplinary, co-produced research agenda
Authors: Fancourt Daisy , Bhui Kamaldeep , Chatterjee Helen , Crawford Paul , Crossick Geoffrey , DeNora Tia , South Jane 
Published: December 2020

Background
There is increasing cross-disciplinary research on the relationship between individuals’ social, cultural and community engagement (SCCE) and mental health. SCCE includes engagement in the arts, culture and heritage, libraries and literature, sports and nature activities, volunteering, and community groups. Research has demonstrated the effects of these activities both on the prevention and management of mental illness. However, it remains unclear whether current research is focusing on the research questions that are of most immediate urgency and relevance to policy and practice.

Aims
The current project was funded as part of the UK Research and Innovation cross-disciplinary mental health network programme to develop and co-produce a new cross-disciplinary research agenda on SCCE and mental health.

Method
Established processes and principles for developing health research agendas were followed, with a six-phase design including engagement with over 1000 key stakeholders, consultations, integration of findings and collective prioritisation of key questions.

Results
We identified four core themes: the mode of engagement, process of engagement, impact of engagement and infrastructure required to facilitate engagement. There were many points of agreement across all stakeholder groups on the priority questions within these themes, but also some specific questions of relevance to different sectors.

Conclusions
This agenda is particularly timely given the extreme pressure on mental health services predicted to follow the current COVID-19 pandemic. It is important to identify how resources from other sectors can be mobilised, and what research questions are going to be most important to fund to support SCCE for mental health.
C–H Activation Catalyzed by Earth-Abundant Metals
Authors: Ilies Laurean 
Published: December 2020

AbstractThis account describes our quest for controlling the reactivity of organoiron species, and developing an iron catalyst that can efficiently activate a C–H bond of a substrate possessing a directing group, followed by reaction with nucleophiles (magnesium, zinc, boron, or aluminum reagents), electrophiles (alkyl halides, alkanol derivatives, allyl ethers, alkenes, alkynes, chloroamines), or with another C–H substrate (heteroarenes or electron-deficient arenes). Our forays into C–H activation using cobalt, manganese, and chromium catalysis are also briefly discussed.
Association between brain morphometry and aerobic fitness level and sex in healthy emerging adults
Authors: Wade Natasha E. , Wallace Alexander L. , Sullivan Ryan M. , Swartz Ann M. , Lisdahl Krista M. 
Published: December 2020

Objective
Aerobic fitness may be beneficial for neuroanatomical structure. However, few have investigated this in emerging adults while also accounting for potential sex differences. Here we examine aerobic fitness level, sex, and their interaction in relation to cortical thickness, surface area, and volume.

Method
Sixty-three young adults between the ages of 16–26 were balanced for sex and demonstrated a wide range of aerobic fitness levels. Exclusion criteria included left-handedness, past-year independent Axis-I disorders, major medical/neurologic disorders, prenatal medical issues, prenatal alcohol/illicit drug exposure, or excessive substance use. Participants completed an MRI scan and a graded exercise test to volitional fatigue (VO2 max). Data analyses were run in Freesurfer and data was corrected for multiple comparisons with Monte Carlo simulations at .05.

Results
Males demonstrated higher VO2 values. Higher VO2 values were statistically independently related to thinner lateral occipital, superior parietal, cuneus, precuneus, and inferior parietal regions, smaller lateral occipital volume, and larger inferior parietal surface area. Compared to females, males had larger volume in rostral anterior cingulate, lateral occipital, and superior frontal regions, and greater surface area in fusiform, inferior parietal, rostral and caudal anterior cingulate, and superior parietal regions. VO2*Sex interactions revealed higher-fit females had higher inferior parietal, paracentral, and supramarginal surface area, while lower-fit males showed larger surface area in these same regions.

Conclusions
Individuals with higher aerobic fitness performance had thinner cortices, lower volume, and larger surface area in sensorimotor regions than lower fit individuals, perhaps suggesting earlier neuromaturation in higher fit individuals. Larger surface area was associated with higher-fit females and lower-fit males. Thus both sex and aerobic fitness are important in shaping brain health in emerging adults.
A systematic scoping review to identify the design and assess the performance of devices for antenatal continuous fetal monitoring
Authors: Tamber Kajal K. , Hayes Dexter J. L. , Carey Stephen J. , Wijekoon Jayawan H. B. , Heazell Alexander E. P. 
Published: December 2020

BackgroundAntepartum fetal monitoring aims to assess fetal development and wellbeing throughout pregnancy. Current methods utilised in clinical practice are intermittent and only provide a ‘snapshot’ of fetal wellbeing, thus key signs of fetal demise could be missed. Continuous fetal monitoring (CFM) offers the potential to alleviate these issues by providing an objective and longitudinal overview of fetal status. Various CFM devices exist within literature; this review planned to provide a systematic overview of these devices, and specifically aimed to map the devices’ design, performance and factors which affect this, whilst determining any gaps in development.MethodsA systematic search was conducted using MEDLINE, EMBASE, CINAHL, EMCARE, BNI, Cochrane Library, Web of Science and Pubmed databases. Following the deletion of duplicates, the articles’ titles and abstracts were screened and suitable papers underwent a full-text assessment prior to inclusion in the review by two independent assessors.ResultsThe literature searches generated 4,885 hits from which 43 studies were included in the review. Twenty-four different devices were identified utilising four suitable CFM technologies: fetal electrocardiography, fetal phonocardiography, accelerometry and fetal vectorcardiography. The devices adopted various designs and signal processing methods. There was no common means of device performance assessment between different devices, which limited comparison. The device performance of fetal electrocardiography was reduced between 28 to 36 weeks’ gestation and during high levels of maternal movement, and increased during night-time rest. Other factors, including maternal body mass index, fetal position, recording location, uterine activity, amniotic fluid index, number of fetuses and smoking status, as well as factors which affected alternative technologies had equivocal effects and require further investigation.ConclusionsA variety of CFM devices have been developed, however no specific approach or design appears to be advantageous due to high levels of inter-device and intra-device variability.
Trends in cardiorespiratory fitness among apparently healthy adults from the Ball State Adult Fitness Longitudinal Lifestyle STudy (BALL ST) cohort from 1970–2019
Authors: Harber Matthew P. , Metz McKenzie , Peterman James E. , Whaley Mitchell H. , Fleenor Bradley S. , Kaminsky Leonard A. 
Published: December 2020

IntroductionCardiorespiratory fitness (CRF) is a strong independent predictor of cardiovascular disease (CVD) and CVD mortality. However, little is known in regards to how CRF has trended in apparently healthy adults over the past several decades.PurposeTo analyze trends in CRF and CVD risk factors over the last 50 years in a population of apparently healthy adult men and women.MethodsParticipants were 4,214 apparently healthy adults (2,390 men and 1,824 women) from theBall StateAdult FitnessLongitudinalLifestyleSTudy (BALL ST) that performed maximal cardiopulmonary exercise testing between 1970–2019 for the assessment of CRF defined as VO2max(ml/kg/min). Participants were self-referred either to a community-based exercise program, fitness testing, or were research subjects in exercise related studies and were placed into groups by decade based on testing date.ResultsCRF showed a general trend to decline (P<0.05) from the 1970s to the 2000s with an increase (P<0.05) from the 2000s to the 2010s for both men and women. This pattern persisted for age and sex-adjusted CRF level, determined by Fitness Registry and the Importance of Exercise: A National Data Base (FRIEND). For both women and men, CRF across the decades was associated (P<0.05) with the prevalence of physical inactivity, smoking, obesity, dyslipidemia and hypertension, and with diabetes in men only.ConclusionCRF declined from 1970 through the 2000s in a cohort of apparently healthy men and women which was associated with worsening CVD risk profiles. However, the decline in CRF was attenuated over the past decade which may have a positive impact on future CVD in the population. Promoting physical activity to increase CRF should be a primary aspect of CVD prevention programs.
Age-related hearing loss in the Korea National Health and Nutrition Examination Survey
Authors: Kim Subin , Park Jung Mee , Han Jae Sang , Seo Jae Hyun , Han Kyung-Do , Joo Young Hoon , Park Kyoung Ho 
Published: December 2020

Objectives
Age-related hearing loss (ARHL), also known as presbycusis, is a chronic disorder characterized by impairment of the transduction of acoustic signals. This study analysed the prevalence and demographic characteristics of ARHL in the Korean population.

Methods
We used the data from the Korea National Health and Nutrition Examination Survey (KNHANES) from 2009 to 2012 and analysed the association between age and hearing impairment. A total of 16,799 adults were selected for the current study. Physical examinations, blood tests, otoscopic examinations, and hearing tests were performed. The demographic variables included age, gender, obesity, economic status, education level, noise exposure history, and underlying diseases.

Results
Among 16,799 participants, the prevalence of unilateral hearing loss was 8% (1,349 people), and bilateral hearing loss was 5.9% (989 people). Men were 53.4% more likely to have hearing loss than women. Age and underlying diseases, like hypertension, diabetes, and abdominal obesity, were significantly associated with hearing loss (P < 0.0001). Further, mental health factors, such as cognitive function, depression, and suicidal ideation, were related to hearing loss. The prevalence of hearing loss increased with advancing years, especially in the high frequency of 6 kHz, with a sharply increase in patients aged 65 and over.

Conclusion
The analysis of auditory performance in the Korean population confirmed the association of high-frequency hearing loss with advancing age. A threshold of 6 kHz should be included to correctly diagnose hearing impairment in elderly patients. Patients with ARHL should be provided with suitable aural rehabilitation that includes active high-frequency control.
Utilization of Whole Exome Sequencing Data to Identify Clinically Relevant Pharmacogenomic Variants in Pediatric Inflammatory Bowel Disease
Authors: Mulder Daniel J. , Khalouei Sam , Warner Neil , Gonzaga-Jauregui Claudia , Church Peter C. , Walters Thomas D. , Ramani Arun K. , Griffiths Anne M. , Cohn Iris , Muise Aleixo M. 
Published: December 2020

INTRODUCTION:
We hypothesized that variants within clinically relevant pharmacogenes could be identified using a whole exome sequencing data set derived from a cohort of more than 1,000 patients with inflammatory bowel disease (IBD).

METHODS:
Pediatric patients diagnosed with IBD underwent whole exome sequencing. We selected 18 genes with supporting literature where specific exonic variants would influence clinical care.

RESULTS:
We identified actionable pharmacogenomic variants in 63% of patients. Importantly, 5% of patients with IBD were at risk for serious adverse effects from anesthesia and 3% were at increased risk for thrombosis.

DISCUSSION:
We identified exonic variants in most of our patients with IBD that directly impact clinical care.