bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Sex Hormone Levels and Risk of Esophageal Adenocarcinoma in a Prospective Study in Men
Authors: Xie Shao-Hua , Ness-Jensen Eivind , Rabbani Sirus , Langseth Hilde , Gislefoss Randi E. , Mattsson Fredrik , Lagergren Jesper 
Published: October 2019

OBJECTIVES:
Sex hormones have been hypothesized to explain the strong male predominance in esophageal adenocarcinoma, but evidence is needed. This study examined how circulating sex hormone levels influence future risk of esophageal adenocarcinoma.

METHODS:
This case-control study was nested in a prospective Norwegian cohort (Janus Serum Bank Cohort), including 244 male patients with esophageal adenocarcinoma and 244 male age-matched control participants. Associations between prediagnostic circulating levels of 12 sex hormones and risk of esophageal adenocarcinoma were assessed using conditional logistic regression. In addition, a random-effect meta-analysis combined these data with a similar prospective study for 5 sex hormones.

RESULTS:
Decreased odds ratios (ORs) of esophageal adenocarcinoma were found comparing the highest with lowest quartiles of testosterone (OR = 0.44, 95% confidence interval [CI] 0.22–0.88), testosterone:estradiol ratio (OR = 0.37, 95% CI 0.19–0.72), and luteinizing hormone (OR = 0.50, 95% CI 0.30–0.98), after adjustment for tobacco smoking and physical activity. These associations were attenuated after further adjustment for body mass index (OR = 0.56, 95% CI 0.27–1.13 for testosterone; OR = 0.46, 95% CI 0.23–0.91 for testosterone:estradiol ratio; OR = 0.55, 95% CI 0.29–1.08 for luteinizing hormone). No associations were observed for sex hormone–binding globulin, dehydroepiandrosterone sulfate, follicle-stimulating hormone, prolactin, 17-OH progesterone, progesterone, androstenedione, or free testosterone index. The meta-analysis showed an inverse association between testosterone levels and risk of esophageal adenocarcinoma (pooled OR for the highest vs lowest quartile = 0.60, 95% CI 0.38–0.97), whereas no associations were identified for androstenedione, sex hormone–binding globulin, estradiol, or testosterone:estradiol ratio.

DISCUSSION:
Higher circulating testosterone levels may decrease the risk of esophageal adenocarcinoma in men.
Sample preparation for Raman microspectroscopy
Authors: Jahn I. J. , Lehniger L. , Weber K. , Cialla-May D. , Popp J. 
Published: October 2019

Abstract
Raman spectroscopy and its variants allow for the investigation of a wide range of biological and biomedical samples, i. e. tissue sections, single cells and small molecules. The obtained information is on a molecular level. By making use of databases and chemometrical approaches, the chemical composition of complex samples can also be defined. The measurement procedure is straight forward, however most often sample preparation protocols must be implemented. While pure samples, such as high purity powders or highly concentrated chemicals in aqueous solutions, can be directly measured without any prior sample purification step, samples of biological origin, such as tissue sections, pathogens in suspension or biofluids, food and beverages often require pre-processing steps prior to Raman measurements. In this book chapter, different strategies for handling and processing various sample matrices for a subsequent Raman microspectroscopic analysis were introduced illustrating the high potential of this promising technique for life science and medical applications. The presented methods range from standalone techniques, such as filtration, centrifugation or immunocapture to innovative platform approaches which will be exemplary addressed. Therefore, the reader will be introduced to methods that will simplify the complexity of the matrix in which the targeted molecular species are present allowing direct Raman measurements with bench top or portable setups.
Isolation and identification of tuliposides D and F from tulip cultivars
Authors: Nomura Taiji , Ogita Shinjiro , Kato Yasuo 
Published: October 2019

Abstract
6-Tuliposides A (6-PosA) and B (6-PosB) are major defensive secondary metabolites in tulip cultivars (Tulipa gesneriana), having an acyl group at the C-6 position of d-glucose. Although some wild tulip species produce 1,6-diacyl-glucose type of Pos (PosD and PosF), as well as 6-PosA/B, they have not yet been isolated from tulip cultivars. Here, aiming at verifying the presence of PosD and PosF in tulip cultivars, tissue extracts of 25 cultivars were analyzed by high-performance liquid chromatography (HPLC). Although no HPLC peaks for PosD nor PosF were detected in most cultivars, we found two cultivars giving a minute HPLC peak for PosD and the other two cultivars giving that for PosF. PosD and PosF were then purified from petals of cultivar ‘Orca’ and from pistils of cultivar ‘Murasakizuisho’, respectively, and their identities were verified by spectroscopic analyses. This is the first report that substantiates the presence of 1,6-diacyl-glucose type of Pos in tulip cultivars.
Accurate Allele Frequencies from Ultra-low Coverage Pool-Seq Samples in Evolve-and-Resequence Experiments
Authors: Tilk Susanne , Bergland Alan , Goodman Aaron , Schmidt Paul , Petrov Dmitri , Greenblum Sharon 
Published: October 2019

Abstract
Evolve-and-resequence (E+R) experiments leverage next-generation sequencing technology to track the allele frequency dynamics of populations as they evolve. While previous work has shown that adaptive alleles can be detected by comparing frequency trajectories from many replicate populations, this power comes at the expense of high-coverage (&gt;100x) sequencing of many pooled samples, which can be cost-prohibitive. Here, we show that accurate estimates of allele frequencies can be achieved with very shallow sequencing depths (&lt;5x) via inference of known founder haplotypes in small genomic windows. This technique can be used to efficiently estimate frequencies for any number of bi-allelic SNPs in populations of any model organism founded with sequenced homozygous strains. Using both experimentally-pooled and simulated samples of Drosophila melanogaster, we show that haplotype inference can improve allele frequency accuracy by orders of magnitude for up to 50 generations of recombination, and is robust to moderate levels of missing data, as well as different selection regimes. Finally, we show that a simple linear model generated from these simulations can predict the accuracy of haplotype-derived allele frequencies in other model organisms and experimental designs. To make these results broadly accessible for use in E+R experiments, we introduce HAF-pipe, an open-source software tool for calculating haplotype-derived allele frequencies from raw sequencing data. Ultimately, by reducing sequencing costs without sacrificing accuracy, our method facilitates E+R designs with higher replication and resolution, and thereby, increased power to detect adaptive alleles.
E-cigarette Marketing Exposure and Subsequent Experimentation Among Youth and Young Adults
Authors: Chen-Sankey Julia Cen , Unger Jennifer B. , Bansal-Travers Maansi , Niederdeppe Jeff , Bernat Edward , Choi Kelvin 
Published: October 2019

OBJECTIVES:
Electronic cigarette (e-cigarette) use has become increasingly prevalent among US youth and young adults in recent years. Exposure to e-cigarette marketing may stimulate e-cigarette use. In this study, we estimated the longitudinal association between e-cigarette marketing exposure and e-cigarette experimentation among US youth and young adult never tobacco users.

METHODS:
The analysis included nationally representative samples of youth (ages 12–17; n = 8121) and young adult (ages 18–24; n = 1683) never tobacco users from wave 2 (2014–2015) and wave 3 (2015–2016) of the Population Assessment of Tobacco and Health Study. In the study, researchers measured past-month exposure to e-cigarette marketing through various places (eg, Web sites and events) at wave 2 and e-cigarette experimentation at wave 3. Statistical analysis included multivariable regressions to examine the associations between wave 2 e-cigarette marketing exposure and wave 3 e-cigarette experimentation.

RESULTS:
At wave 2, 70.7% of youth and 73.9% of young adult never tobacco users reported past-month exposure to e-cigarette marketing; at wave 3, 4.9% and 4.5% of youth and young adults experimented with e-cigarettes, respectively. Youth and young adults exposed to e-cigarette marketing at wave 2 were more likely (adjusted odds ratio = 1.53, 95% confidence interval = 1.07–2.17; and adjusted odds ratio = 2.73, 95% confidence interval = 1.16–6.42, respectively) to have experimented with e-cigarettes at wave 3 than those not exposed. Marketing exposure through each place at wave 2 was associated with e-cigarette experimentation at wave 3.

CONCLUSIONS:
E-cigarette marketing exposure predicted subsequent e-cigarette experimentation among youth and young adult never tobacco users. Increased restrictions on marketing through various channels may help minimize their exposure to e-cigarette marketing messages.
Az elhízás mozgásszervi vonatkozásai: egy régi téma új megközelítésben
Authors: Tamási László , Miksi Ágnes , Kardos Zsófia , Flórián Ágnes , Szekanecz Zoltán 
Published: October 2019

Abstract: Authors discuss the musculoskeletal aspects of obesity by applying a novel approach. Biochemical changes associated with obesity and especially metabolic syndrome, may have a great impact on the function of bones, joints and muscles. Therefore we need a new view and new strategies in rheumatic diseases. Obesity-associated metabolic changes should be considered during the progress of as well as the selection of treatment in inflammatory rheumatic diseases. Individualised treatment is necessary due to associated comorbidities as well. Orv Hetil. 2019; 160(44): 1727–1734.
SYNTHESIS OF COPPER NANOPARTICLES WITH VARIOUS SIZES TOWARDS IMPROVING THE ELECTRICAL CONDUCTIVITY OF COPPER FILMS AT LOW SINTERING TEMPERATURE
Authors: Luu Anh Tuan , Vuong Dat Vinh , Nguyen Anh Phan Nhat 
Published: October 2019

The use of copper nanoparticles (CuNPs) in conductive inks has attracted much attention to printed circuit board manufacturers due to its high electrical conductivity and low cost. The synthesis of CuNPs by surfactant-assisted chemical reduction method was studied aiming to identify the content of PVP-surfactant corresponding to the size of copper particles. The crystallite size and phase of CuNPs were determined by X-ray diffraction (XRD) analysis while transmission and scanning electron microscopy (TEM and SEM) were used to characterize the size of copper particles. The results showed that the crystallite and particle size of CuNPs decrease with increasing the PVP-surfactant concentration. The crystallite size values measured by TEM and XRD methods have a slight variation. The copper films were fabricated by the doctor-blade technique on PI and Al2O3 substrates. The effect of sintering temperature on conductive properties of the copper film after sintering was investigated. The copper film was sintered at low temperatures below 300oC. The electrical conductivity of copper films was measured by using the four-point probe method. The electrical resistivity of copper films archives stable at the low sintering temperature above 200°C about 0.22 mΩ.cm and 0.63 mΩ.cm for that of Al2O3 and PI substrates respectively.
A Rare EGFR–SEPT14 Fusion in a Patient with Colorectal Adenocarcinoma Responding to Erlotinib
Authors: Li Yong , Zhang Hai-Bo , Chen Xian , Yang Xiaobing , Ye Yongsong , Bekaii-Saab Tanios , Zheng Yaojie , Zhang Yihong 
Published: October 2019

Abstract

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Growing evidence supports gene fusions as good candidates for molecularly targeted therapy in CRC. Here we describe a case of a 63-year-old man who had a radical right hemicolectomy procedure 24 months ago. Pathological diagnosis indicated colorectal adenocarcinoma with stage pT4N2bMx. During re-examination in December 2016, positron emission tomography/computed tomography scans indicated relapse with multiple lymph nodes metastasis. Then the patient received a nine-cycle combination treatment of XELOX and bevacizumab and showed progressive disease (PD). Subsequently, the patient was treated with bevacizumab plus FOLFIRI for 2 months before discontinuation because of adverse events. Paraffin sections of postoperative colorectal tissue were subjected to next-generation sequencing, and epidermal growth factor receptor (EGFR) amplification and rare EGFR–SEPT14 fusion were identified. The patient then received erlotinib, an EGFR tyrosine kinase inhibitor (TKI), and achieved a partial response. However, the patient subsequently showed PD, and a new variant, EGFRvIII, appeared in metastasis, which may be involved in erlotinib resistance. We suggest that there is value in treating patients harboring EGFR fusions with EGFR TKI therapy, and EGFR–SEPT14 fusion may be used as a therapeutic target for CRC.

Key Points
To the authors' knowledge, this is the first report of EGFR–SEPT14 fusion in colorectal cancer. The patient achieved a partial response after treatment with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib. This report expands the list of gene fusions in colorectal cancer and highlights new targets for the therapeutic intervention. EGFRvIII may be involved in erlotinib resistance, which is rare in colorectal cancer.
Plastik Sanatlarda Küratör Figürü ve Sanatçının Araçsallaştırılması
Authors: KUŞ Metin 
Published: October 2019

Görsel sanatlar, bütün uygarlıklarda, varoluşlarını çeşitli sosyal kültürel yapılarla ilişkilendirerek sağlamışlardır. Bu durum, görsel sanatların kendi dinamiklerinden kaynaklanan bir ihtiyaç değil daha çok izleyici konumundaki insanların algılamalarına ilişkin bir gereklilik olarak ortaya çıkmıştır. Sanatın, ‘Batı Kültürü’ çerçevesindeki başlangıcı olarak kabul edilen ve tüm bu sürece karakterini ve biçimini vermiş olan Antik Yunan kültürü içinde oluşmuş sosyal yaşam, sanat, eğitim ve felsefe bağlamında oluşmuş paradigmaların günümüze kadar nasıl dönüştüğünü veya niteliksel olarak dönüşmeden yansıdığını dil ve görsellik üzerinden genel hatlarıyla inceleyip bu olguyu günümüz toplumunun en önemli iletişim unsuru olan retorik ve bu unsurun görsel sanatlarda yaratmış olduğu küratör figürünü incelemek bu çalışmanın amacı olarak düşünülmüştür.
“MOVIDA PELA PAIXÃO”: gênero, raça e classe no Processo criminal de Angela Davis
Authors: Braga Ana Gabriela Mendes 
Published: October 2019

Este paper apresenta algumas reflexões da pesquisa de Pós-doutoramento denominada “Levada pela paixão”: gênero, raça e classe no processo criminal de Angela Davis que tem por objetivo investigar um caso de produção da subjetividade da mulher criminosa pelo sistema de justiça criminal. Trata-se de um trabalho empírico de natureza qualitativa com uso de análise documental, com o objetivo de compreender a operação discursiva e performática de transformar um ícone- uma intelectual feminista negra, àquela altura já doutora em filosofia- em uma “mulher movida pela paixão”. Inspirada pela epistemologia feminista negra proponho a estratégia do estudo de caso único para pensar os marcadores sociais de classe, raça e gênero articulados no processo criminal de Angela Davis como significativos também em outras experiências no sistema de justiça criminal. Ao final, busco retratar como a experiência de Angela Davis com a justiça criminal e o relato dela sobre a mesma, no duplo ré-autora, pode contribuir na discussão dos processo de criminalização e subjetivação feminina negra, situando esta pesquisa em um debate mais amplo acerca das relações de gênero, raça, classe e direito, o qual nos parece um horizonte necessário e promissor para o campo jurídico e criminológico brasileiro.
Biber (Capsicum annuumL.) Genotiplerinin SSR Markörleri ile Genetik Karakterizasyonu
Authors: KARAKURT Yaşar , GÜVERCİN Damla , CESUR Ezgi 
Published: October 2019

Amaç: Biber (Capsicum annuum) genotiplerinin SSR
markörleri ile genetik karakterizasyonuyapılmıştır.

Materyal ve Metot:Çalışmada
kullanılan biber çeşitleri Akdeniz Bölgesinde yer alan Antalya ilindeki çeşitli
fide şirketlerinden temin edilmiştir. Toplamda 10 çeşit biber fidesi ve 10 SSR
primeri ile PCR çalışmaları yürütülmüştür.

Bulgular: SSR markörleri
ile yapılan UPGMA analizleri sonucunda biber çeşitleri 2 ana gruba ayrılmıştır.
Birinci ana grup iki alt gruba ayrılmıştır. İlk alt grupta Vezir, Üçburun,
Acıburun, Yükselince, Anadol, Serenad, Hayfa Şili yer almaktadır. İkinci alt
grupta ise Jalomex yer almaktadır. İkinci ana grupta Ergenekon ve Kanyon genotipleri
yer almaktadır. Vezir- Üçburun ve Yükselince- Anadol çeşitleri benzer gruplar
olup incelenen SSR bölgeleri bakımından benzer özellik göstererek birlikte
gruplanmıştır. Ergenekon- Kanyon, Serenad- Hayfa Şili kendi aralarında
benzerlik gösteren diğer gruptur. En uzak benzerlik Jalomex ve Ergenekon
arasında olup, ikinci uzak benzerlik Jalomex- Kanyon arasındadır. Toplam allel
sayısının 162, spesifik allel sayısının 60 olduğu ve bant büyüklüğünün ise 164
ile 294 bç arasında değiştiği belirlenmiştir. Polimorfik bilgi içeriği (PBİ)
0,04 ile 0,89 arasında değişim göstermiştir.

Sonuç:Türkiye’deki biber
türlerine ait SSR bulgularımız, bölgede bundan sonraki ıslah çalışmalarında
ebeveyn seçiminde bir basamak oluştururken, biber genotiplerinin yayılma
alanlarının belirlenmesinde, genetik koleksiyonların karşılaştırılmasında, biber genotiplerinin karakterizasyonunda
kullanılabilir.
HOW MIGRANTS FROM CITIES BECOME POTENTIAL INNOVATORS IN KOREAN RURAL COMMUNITIES
Authors: Cho Oakla 
Published: October 2019

Since 2010 there were more migrants from urban center to rural area due to the increase of retirees population and willingness to seek alternative lifestyles to a neo-liberal society. By this migrants movement, rural policy makers expected and considered as a new source of labor to supplement the farming industry and to vitalize social activities in rural society, and to provide organizational ability to systemize rural projects in order to cope with a changing environment. However, it is not quite clear how these migrants may bring about changes in farming and in local communities. This paper will discuss the conditions and potentiality of these migrants in relation to farming projects. The paper argued that most migrants were well-educated, innovators for new farming practices, market oriented, tend to engage in health food production, and emphasize on eco-farming or environmentally friendly farming. As newcomers they have limitations in regards to farming technology, knowledge, physical power and land holdings. In regards to eco-friendly farming, they seem to be influenced more by NGOs and governmental support for organic farming. The migrants who do not farm mostly involved in village projects during the course of implementation. It was concluded that the migrants were very valuable assets to rural community and play a crucial role in putting together various interest groups in villages and establishing income-generating projects so that villagers can start being optimistic about their future.
Functional Outcomes and Complications Following Scapulothoracic Arthrodesis in Patients with Facioscapulohumeral Dystrophy
Authors: Eren İlker , Erşen Ali , Birsel Olgar , Atalar Ata Can , Oflazer Piraye , Demirhan Mehmet 
Published: October 2019

Background:
Facioscapulohumeral dystrophy (FSHD) is an autosomal-dominant myopathy characterized by facial and shoulder girdle muscle weakness with scapular winging. Scapulothoracic arthrodesis is a successful treatment approach for patients with <90° of shoulder elevation. The purpose of the present study was to assess functional outcomes and complications following scapulothoracic arthrodesis in patients with FSHD.

Methods:
We retrospectively reviewed the records of 40 patients (64 shoulders) in whom scapulothoracic arthrodesis was performed. To achieve fusion, multiple multifilament cables were used together with autologous bone and allograft bone. Preoperative and postoperative shoulder elevation and abduction; Disabilities of the Arm, Shoulder and Hand (Quick version, qDASH) scores; and pulmonary function were compared. Recorded complications were classified as pulmonary or scapular.

Results:
The mean age of the patients at the time of the operation was 25.4 years (range, 15 to 60 years), and the mean duration of follow-up was 71.2 months (range, 12 to 185 months). When the preoperative values were compared with those at the latest follow-up, significant improvement was noted in terms of elevation (from a mean [and standard deviation] of 60.6° ± 17.2° to 123.7° ± 26.7°; p < 0.001), abduction (from 52.7° ± 15.8° to 98.8° ± 20.3°; p < 0.001), and qDASH scores (from 34.7 ± 11.4 to 13.3 ± 13.1; p < 0.001). The overall complication rate was 26.6%. There were 7 pulmonary complications (4 pneumothoraxes, 2 pleural effusions, and 1 major atelectasis), and 5 chest tube placements were required. Ten complications (including 3 rib fractures, 1 brachial plexus palsy, 2 cases of implant irritation, 2 nonunions, 1 delayed union, and 1 scapular fracture) were related to the scapular fixation, and 7 revision procedures were required. Scapulothoracic fusion was achieved in all patients but 1, who had a scapular fracture. Pulmonary function tests were performed for 19 patients, and no difference was observed between preoperative and postoperative results.

Conclusions:
Scapulothoracic arthrodesis with use of multifilament cables is a successful surgical technique with high fusion rates and low morbidity. Pulmonary complications are common but resolve with careful attention.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.