bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring health promotion research impact – What researchers think?
Authors: Jancey Jonine , Burns Sharyn , Hendriks Jacqui , Pollard Christina Mary , Tohatoa Jennifer , Hallett Jonathan 
Published: June 2020

AbstractIssues addressedThe significant investment in health research has resulted in an increased focus to determine suitable approaches to measure health promotion research impact. This research was undertaken at the request of a nationally competitive research organisation that funds health promotion research, to explore how Chief Investigators (CIs) on their funded projects understood research impact, its measurement and associated challenges.MethodsParticipants were required to be or have been a CI on an Australian competitive research (exploratory or intervention) grant focussed on health promotion. The qualitative study used thematic analysis from one‐on‐one interviews. Themes were created and descriptive quotes were selected to illustrate the main findings.ResultsThe majority of participants were female (n = 13) working at a university (n = 13). Three themes emerged: a) defining health research impact; b) complexity and simplicity of measuring health research impact; c) challenges of measuring health research impact: i) differing language; ii) differing assessment; iii) attribution and timing; and iv) resourcing and skills.ConclusionResearchers recognised that there are significant challenges in measuring the impact of health promotion research. The most significant factors identified by participants were the disciplinary background of the researchers undertaking the measurement, their skills and experience and the resources (including time) available to assess impact.So what?Research impact assessment is complex, time consuming and requires specific skills to facilitate measurement of impact provision of funding for this activity in research grants and research impact training is required.
Parent–Child Interaction Therapy with Toddlers in a community‐based setting: Improvements in parenting behavior, emotional availability, child behavior, and attachment
Authors: Kohlhoff Jane , Morgan Susan , Briggs Nancy , Egan Ryan , Niec Larissa 
Published: June 2020

ABSTRACTParent–Child Interaction Therapy with Toddlers (PCIT‐T) is a new attachment‐based parenting intervention designed to meet the needs of children aged 12–24 months presenting with challenging behaviors. This study examined outcomes of the first phase of PCIT‐T, Child Directed Interaction–Toddler (CDI‐T), 4‐months post treatment. Participants were 56 toddlers (Child Mage = 19.13 months) referred to receive CDI‐T over an 8‐week period at an Australian community‐based child behavior treatment clinic for treatment of difficult toddler behaviors. Participants completed questionnaires and observational measures at baseline (Time 1), post‐treatment (Time 2), and 4‐month follow‐up (Time 3). At both Time 2 and Time 3, there were statistically significant increases in observed positive parenting skills and emotional availability and decreases in negative parenting behaviors and child noncompliance. There were also significant improvements in parent‐reported child externalizing and internalizing behaviors, parental stress, and maternal depression. There was a pattern of a shift away from attachment insecurity and attachment disorganization. Results suggest that the CDI‐T phase of PCIT‐T is a promising intervention for toddlers presenting with behavioral issues. Future studies should be conducted to assess efficacy in other settings, using larger samples and utilizing randomized controlled designs.
Early childhood mental health consultation: Care providers’ experiences of the consultative relationship
Authors: Kniegge‐Tucker Krystal , Yuma Paula , Caplovitz‐Barrett Karen , Miles Brenda 
Published: June 2020

ABSTRACTThis article presents findings from a qualitative research study exploring child care teachers’ experiences receiving early childhood mental health consultation (ECMHC). As an emerging intervention in early childhood education, ECMHC is already yielding promising results, namely in helping teachers better address challenging behaviors in their classroom and promote a more nurturing classroom environment. However, there remains a lack of personal testimony from teachers who receive this intervention. Considering that teachers are the primary focus of most ECMHC interventions, the purpose of this study was to examine child care teachers’ personal experiences receiving consultation. Eight child care teachers were interviewed for this study. Results from this study illuminate key interpersonal processes in the development of the consultant–consultee relationship, indicate what teachers consider to be the most helpful components of consultation, and speak to the challenges that teachers experience in consultation. By examining the personal testimony of child care teachers who have received ECMHC services, consultants and researchers can consider ways to expand and improve future implementation of ECMHC.
Infrared attenuated total reflection spectroscopic surface analysis of bovine‐tail intervertebral discs after UV‐light‐activated riboflavin‐induced collagen cross‐linking
Authors: Vasilikos Ioannis , Haas Julian , Teixeira Graciosa Q. , Nothelfer Julia , Neidlinger‐Wilke Cornelia , Wilke Hans‐Joachim , Seitz Andreas , Vavvas Demetrios G. , Zentner Josef , Beck Jürgen , Hubbe Ulrich , Mizaikoff Boris 
Published: June 2020

AbstractThe tensile strength of the intervertebral disc (IVD) is mainly maintained by collagen cross‐links. Loss of collagen cross‐linking combined with other age‐related degenerative processes contributes to tissue weakening, biomechanical failure, disc herniation and pain. Exogenous collagen cross‐linking has been identified as an effective therapeutic approach for restoring IVD tensile strength. The current state‐of‐the‐art method to assess the extent of collagen cross‐linking in tissues requires destructive procedures and high‐performance liquid chromatography. In this study, we investigated the utility of infrared attenuated total reflection (IR‐ATR) spectroscopy as a nondestructive analytical strategy to rapidly evaluate the extent of UV‐light‐activated riboflavin (B2)‐induced collagen cross‐linking in bovine IVD samples. Thirty‐five fresh bovine‐tail IVD samples were equally divided into five treatment groups: (a) untreated, (b) cell culture medium Dulbecco's Modified Eagle's Medium only, (c) B2 only, (d) UV‐light only and (e) UV‐light‐B2. A total of 674 measurements have been acquired, and were analyzed via partial least squares discriminant analysis. This classification scheme unambiguously identified individual classes with a sensitivity >91% and specificity >92%. The obtained results demonstrate that IR‐ATR spectroscopy reliably differentiates between different treatment categories, and promises an excellent tool for potential in vivo, nondestructive and real‐time assessment of exogenous IVD cross‐linking.
Visible‐near infrared‐II skull optical clearing window for in vivo cortical vasculature imaging and targeted manipulation
Authors: Li Dong‐Yu , Zheng Zheng , Yu Ting‐Ting , Tang Ben‐Zhong , Fei Peng , Qian Jun , Zhu Dan 
Published: June 2020

AbstractSkull optical clearing window permits us to perform in vivo cortical imaging without craniotomy, but mainly limits to visible (vis)‐near infrared (NIR)‐I light imaging. If the skull optical clearing window is available for NIR‐II, the imaging depth will be further enhanced. Herein, we developed a vis‐NIR‐II skull optical clearing agents with deuterium oxide instead of water, which could make the skull transparent in the range of visible to NIR‐II. Using a NIR‐II excited third harmonic generation microscope, the cortical vasculature of mice could be clearly distinguished even at the depth of 650 μm through the vis‐NIR‐II skull clearing window. The imaging depth after clearing is close to that without skull, and increases by three times through turbid skull. Furthermore, the new skull optical clearing window promises to realize NIR‐II laser‐induced targeted injury of cortical single vessel. This work enhances the ability of NIR‐II excited nonlinear imaging techniques for accessing to cortical neurovasculature in deep tissue.
On being “cool”
Authors: Phillips Sidney H. 
Published: June 2020

AbstractThe term “cool” likely originated in American jazz in the 1940s and was a superlative that indicated significant achievement within an aesthetic of restraint. Over the ensuing decades, the word evolved to mean a rebellious vision that breaches tradition and repudiates past versions of cool. Even though its linguistic roots are West African, the term accrued distinctly American connotations in racist, sexist, and homophobic contexts. The shimmering, mysterious indefinability of coolness—its you‐know‐it‐when‐you‐see‐it quality—helped conceal its phobic qualities. The author examines the homophobic context through the lens of an icon of cool, James Dean, who became for gay men an object both of identification and erotic desire. The essay considers whether the restraint of coolness is only masquerade, a product of disavowed bodily anxiety, or if it also represents integration and meaningful transformation. A clinical vignette and scenes from the film Rebel Without a Cause are used to exemplify these dilemmas from a psychoanalytic point of view.
Alcohol use severity, depressive symptoms, and optimism among Hispanics: Examining the immigrant paradox in a serial mediation model
Authors: Cobb Cory L. , Schwartz Seth J. , Salas‐Wright Christopher P. , Pinedo Miguel , Martinez Priscilla , Meca Alan , Isaza Alejandra G. , Lorenzo‐Blanco Elma I. , McClure Heather , Marsiglia Flavio F. , Martínez Charles R. , Cano Miguel Ángel 
Published: June 2020

AbstractObjectiveHispanic immigrants exhibit more positive outcomes than U.S.‐born Hispanics across educational, psychological, and physical health indices, a phenomenon called the immigrant paradox. We examined the immigrant paradox in relation to alcohol use severity among Hispanic young adults while considering both positive (optimism) and negative (depressive symptoms) processes.MethodAmong 200 immigrant and U.S.‐born Hispanic young adults (Mage = 21.30; 49% male) in Arizona and Florida, we tested whether optimism and depressive symptoms statistically mediated the relationship between nativity and alcohol use severity. Specifically, we examined whether Hispanic immigrants reported greater optimism than their U.S.‐born counterparts, and whether such optimism was, in turn, associated with less depressive symptoms and thus lower alcohol use severity.ResultsIndirect effects were significant in hypothesized directions (nativity → optimism → depressive symptoms → alcohol use severity).ConclusionsBoth positive and negative psychological processes are important to consider when accounting for the immigrant paradox vis‐à‐vis alcohol use severity among Hispanic young adults.
Exploring the potential moderating role of self‐compassion on the relationships between event centrality and post‐assault psychological outcomes
Authors: Hamrick Lauren A. , Owens Gina P. 
Published: June 2020

AbstractObjectiveThe present study examined whether post‐assault internal processes (i.e., present control, event centrality, and compassionate and uncompassionate self‐responding) were associated with distress and resilience among women who have experienced adult sexual assault. The authors also tested whether compassionate and uncompassionate self‐responses would moderate the relationships between event centrality and outcomes.MethodA convenience sample of women who had experienced sexual assault during adulthood (N = 253) completed an anonymous online survey.ResultsRegression analyses showed that lower present control, higher event centrality, and higher uncompassionate responses to the self were associated with posttraumatic stress disorder. Additionally, higher present control and higher compassionate responses to the self were associated with resilience. Moderation analyses were not significant.ConclusionsEndorsing greater levels of uncompassionate responses was associated with greater distress while engaging in greater compassionate responses was associated with greater resilience, even when accounting for levels of present control and event centrality.
Involvement of mechanosensitive ion channels in the effects of mechanical stretch induces osteogenic differentiation in mouse bone marrow mesenchymal stem cells
Authors: Wu Tianyi , Yin Fuli , Wang Nan , Ma Xin , Jiang Chaolai , Zhou Lihui , Zong Yang , Shan Haojie , Xia Wenyang , Lin Yiwei , Zhou Zubin , Yu Xiaowei 
Published: June 2020

AbstractBone marrow mesenchymal stem cells (BMSCs) can be induced to process osteogenic differentiation with appropriate mechanical and/or chemical stimuli. The present study described the successful culture of murine BMSCs under mechanical strain. BMSCs were subjected to 0%, 3%, 8%, 13%, and 18% cyclic tensile strain at 0.5 Hz for 8 hr/day for 3 days. The expression of osteogenic markers and mechanosensitive ion channels was evaluated with real‐time reverse transcription‐polymerase chain reaction (RT‐PCR) and western blot. The expression of alkaline phosphatase (ALP) and matrix mineralization were evaluated with histochemical staining. To investigate the effects of mechanosensitive ion channel expression on cyclic tensile strain‐induced osteogenic differentiation, the expression of osteogenic markers was evaluated with real‐time RT‐PCR in the cells without mechanosensitive ion channel expression. This study revealed a significant augment in osteogenic marker in BMSC strained at 8% compared to other treatments; therefore, an 8% strain was used for further investigations. The ALP expression and matrix mineralization were enhanced in osteogenic induced BMSCs subjected to 8% strain after 7 and 14 days, respectively. Under the same conditions, the osteogenic marker and mechanosensitive ion channel expression were significantly promoted. However, the loss function of mechanosensitive ion channels resulted in the inhibition of osteogenic marker expression. This study demonstrated that strain alone can successfully induce osteogenic differentiation in BMSCs and the expression of mechanosensitive ion channels was involved in the process. The current findings suggest that mechanical stretch could function as efficient stimuli to induce the osteogenic differentiation of BMSCs via the activation of mechanosensitive ion channels.
Absence of the MFG‐E8 gene prevents hypoxia‐induced pulmonary hypertension in mice
Authors: Wang Jun , Wu Jixing , Zhu Xianying , Chen Jinkun , Zhao Jianping , Xu Yongjian , Xie Jungang 
Published: June 2020

AbstractPulmonary hypertension (PH) is a chronic vascular disease characterized by elevated pulmonary arterial resistance and vascular remodeling, and chronic hypoxia plays an important role in PH. Milk fat globule‐EGF factor 8 (MFG‐E8) is a glycoprotein that regulates cell proliferation and apoptosis, but its role in hypoxia‐induced PH is unknown. The current study aimed to determine the function and fundamental mechanisms of MFG‐E8 in hypoxia‐induced PH. Herein, we exposed mice to hypoxia for 5 weeks, and MFG‐E8 was found to be elevated in mouse lung tissues, arteries, and plasma. Compared with wild‐type littermates, mice lacking MFG‐E8 showed a significant increase in the ratio of pulmonary artery acceleration time to ejection time (PAT/PET), while they showed decreases in right ventricular systolic pressure, the Fulton's Index, percent medial wall thickness (%WT), and vascular muscularization in pulmonary arteries. In addition, MFG‐E8 protein levels were also increased in the serum of patients with chronic PH. Similarly, we observed a higher expression of MFG‐E8 in human pulmonary artery smooth muscle cells (PASMCs) in the presence of hypoxic stimulation than MFG‐E8 in cells in normoxic conditions. Furthermore, MFG‐E8 silencing resulted in partial inhibition of proliferation, migration and cell cycle progression in human PASMCs, and the possible mechanisms might involve the interaction between MFG‐E8 and the p‐Akt/cyclin D1 pathway. Collectively, our study suggests that the absence of MFG‐E8 can attenuate the development of hypoxia‐induced PH and vascular remodeling. MFG‐E8 can be a potential therapeutic target or a biomarker for PH.
Hsa_circ_001988 attenuates GC progression in vitro and in vivo via sponging miR‐197‐3p
Authors: Sun Dan , Wang Gang , Xiao Chang , Xin Yan 
Published: June 2020

AbstractHsa_circ_001988 has been identified as a tumor suppressor gene in several carcinomas. However, its expression pattern and role in gastric cancer (GC) have still remained elusive. This study aimed to explore the functions of hsa_circ_001988 in GC. Quantitative reverse transcription polymerase chain reaction assay was performed to assess the expressions of hsa_circ_001988, miR‐197‐3p, FBXW7, CCDC6, and U2AF65 in GC tissues. The correlation analysis was undertaken to find out the relationship between hsa_circ_001988 expression and clinicopathological factors. A series of cellular experiments were carried out to describe the effects of hsa_circ_001988 on GC in vivo and in vitro. Besides, RNA immunoprecipitation (RIP) assay was performed to verify the relationship among EIF4A3, U2AF65, and hsa_circ_001988. We first found that the expression of hsa_circ_001988 was decreased in 341 GC patients that was related to World Health Organization histological types, Lauren types, and tumor invasion depth (p < .05). Silencing of hsa_circ_001988 facilitated proliferation, colony formation, migration, and invasion of GC cells, while overexpression of hsa_circ_001988 reversed the effect on GC progression in vitro. Additionally, the results of subcutaneous xenotransplanted tumor model demonstrated that overexpressing hsa_circ_001988 significantly suppressed the subcutaneous tumor growth in vivo. Mechanistically, hsa_circ_001988 attenuated the miR‐197‐3p expression possibly due to its molecular sponge effect, and then, positively promoted FBXW7 expression. Afterwards, FBXW7 regulated the expressions of yes‐associated protein 1, cyclinD1, CCDC6, and EMT‐related proteins. Notably, RIP assay showed the enrichment relationship among EIF4A3, U2AF65, and hsa_circ_001988. Additionally, EIF4A3 or U2AF65 promoted cyclization of hsa_circ_001988 in GC. Hsa_circ_001988 inhibits the proliferation and metastasis of GC via modulating EIF4A3/U2AF65‐mediated hsa_circ_001988/miR‐197‐3p/FBXW7 axis.
Cx31.1 expression is modulated in HaCaT cells exposed to UV‐induced damage and scrape‐wounding
Authors: Nugent Louise , Ofori‐Frimpong Boatemaa , Martin Patricia E. , Green Colin R. , Wright Catherine S. 
Published: June 2020

AbstractConnexin31.1 (Cx31.1) is a gap junction protein associated with apoptosis. In the skin, apoptosis is modulated by diabetes. A HaCaT skin model investigated whether normal (NGI) and high glucose and insulin (HGI; diabetic) conditions altered Cx31.1 expression, and if these were apoptosis linked. Cx31.1 was found in HaCaT and HeLa Ohio cells, with HaCaT Cx31.1 protein increased in HGI conditions, and around apoptotic cells. HeLa Cx31.1 channels were noncommunicative. Post scrape‐wounding, Cx31.1 increased at wound edges. Caspase 3/7 in scrape‐wounds media (containing cells) elevated in HGI. UV exposure raised Cx31.1, and caspase 3/7, in NGI and HGI. UV reduced cell viability in NGI cells, although not significantly in HGI. Cx31.1 is modulated during HaCaT cell wound closure, and associated with ‘diabetic’ conditions. Cx31.1 expression matched apoptosis levels, higher in HGI cultures. Cx31.1 is noncommunicating, modulated after wounding, linked to apoptosis, and may be associated with tissue turn‐over around diabetic wounds.
Design and synthesis of azaindole heterocycle decorated new scaffold in fluorometric sensing of F− and H2PO4−
Authors: Ghosh Kumaresh , Ali Sk. Sarfaraj , Joardar Soumen 
Published: June 2020

Abstract7‐Azaindole has been used in designing new molecular structure 1 on enediyne spacer for its application in anion sensing. New structure 1 has been established as efficient fluorescent sensor of H2PO4− and F− ions in CH3CN containing 1% DMSO. While in presence of H2PO4− the emission at 418 nm is decreased to the significant extent in nonratiometric fashion, a ratiometric response in presence of F− is noted with a sharp isoemissive point and two anions are effectively distinguished over a series of other anions tested. A similar study on model compound 2 with indole motifs is done to prove the pivotal role of extra ring nitrogen in azaindole of 1 in the binding process.
Gendered health institutions: examining the organization of health services and men’s use of HIV testing in Malawi
Authors: Dovel Kathryn , Dworkin Shari L , Cornell Morna , Coates Thomas J. , Yeatman Sara 
Published: June 2020

AbstractIntroductionMen in sub‐Saharan Africa are less likely to use HIV testing services than their female counterparts. Norms of masculinity are frequently cited as the main barrier to men’s use of HIV testing services, but very little is known about how health institutions are organized to facilitate or impede men’s care. We examined the organization of health institutions in Malawi, and implications for men’s use of HIV testing services.MethodsA mixed methods ethnography was conducted in Malawi between October 2013 and September 2014. National Ministry of Health guidelines from 2012 to 2014 were analysed, counting the frequency of recommended preventative services by sex. In‐depth interviews were conducted with 18 healthcare workers and 11 national key informants (29 total). Five rural health facilities participated in direct observation and 52 observational journals were completed to document the structure and implementation of HIV services within local facilities. All data were analysed using the theory of gendered organization. Findings were grouped into one of the three theoretical levels of organization: (1) organizational policy; (2) organizational practice; and (3) structure of gendered expectations.ResultsHealth institutions were gendered across three levels. Organizational policy: National guidelines omitted young and adult men’s health during reproductive years (176‐433 recommended visits for women vs. 32 visits for men). Health education strategies focused on reproductive and child health services, with little education strategies targeting men. Organizational practice: HIV testing was primarily offered during reproductive and child health services and located near female‐focused departments within health facilities. As these departments were women’s spaces, others could easily tell that men were using HIV services. Structure of gendered expectations: Clients who successfully accessed HIV testing services were perceived as exemplifying characteristics that were traditionally considered feminine: compliance (obeying instructions without explanation); deference (respecting providers regardless of provider behaviour); and patience (“waiting like a woman”).ConclusionsHealth institutions in Malawi were organized in ways that created substantial, multilevel barriers to men’s HIV testing and reinforced perceptions of absent, difficult men. Future research should prioritize a gendered organization framework to understand and address the complex realities of men’s constrained access to HIV services.