bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Obtaining a Diagnosis of Interstitial Cystitis/Bladder Pain Syndrome Improve Symptoms or Quality of Life? A Cross-sectional Questionnaire-Based Study
Authors: Volpe Katherine A. , Mandelbaum Rachel , Rodriguez Larissa V. , Özel Begüm Z. , Rolston Renee , Dancz Christina E. 
Published: April 2020

Objectives
The aim of this study was to investigate whether receiving a clinical diagnosis of interstitial cystitis (IC) or bladder pain syndrome (BPS) improves patients’ symptoms, health-related quality of life (HRQOL), or ability to cope with their symptoms.

Methods
In this cross-sectional study, participants with self-reported IC/BPS completed an online questionnaire recalling their perceived change in symptoms after diagnosis and treatment. The questionnaire included demographic information, overall HRQOL measured on a visual analog scale (VAS), O’Leary-Sant Interstitial Cystitis Problem Index, the Urinary Impact Questionnaire, and questions regarding patient beliefs about diagnosis. HRQOL and symptom impact scales were compared before and after diagnosis and treatment. Demographic data, symptom data, and beliefs were examined for correlation with improvement in quality of life after diagnosis.

Results
A total of 1052 participants initiated the survey and were included in the analysis; most of them identified as female, non-Hispanic, and white (90%). Before symptom onset, median VAS HRQOL score was 87 (interquartile range [IQR], 77–95). Median scores nadired at 34 (IQR, 20–59) after symptom onset before diagnosis, but improved to 61 after diagnosis and treatment (IQR, 38–74; all P < 0.001). Scores remained stable after diagnosis and initiation of treatment with a median score of 65 at the time of survey (IQR, 37–80; P > 0.05). Age, insurance type, and improvement in scores on the symptom impact scale predicted improvement in HRQOL after diagnosis and treatment in the multivariable model.

Conclusions
Participants reported improvements on global and symptom-specific quality of life measures after diagnosis and treatment for IC/BPS.
Effectiveness of Botulinum Toxin for Treatment of Symptomatic Pelvic Floor Myofascial Pain in Women: A Systematic Review and Meta-analysis
Authors: Meister Melanie R. , Brubaker Allison , Sutcliffe Siobhan , Lowder Jerry L. 
Published: April 2020

Objectives
The aims of the study were to systematically review the literature and to synthesize the evidence for the effectiveness of botulinum toxin injection to the pelvic floor muscles for treating pelvic floor myofascial pain in female patients.

Methods
This systematic literature search was performed in February 2018 and updated in September 2019. Articles were screened based on predefined criteria: (1) adult population, (2) female patients, (3) treatment of pelvic pain by transvaginal botulinum toxin injection into the pelvic floor, (4) published in English or English translation available, (5) study design including randomized controlled trials, cohort studies, and case series with more than 10 participants, and (6) quantitative report of pain scores. Nine studies were included in the primary analysis, and an unpublished study was included in a sensitivity analysis. A random effects model with robust variance estimation was used to estimate the pooled mean difference in patient-reported pain scores after botulinum toxin injection.

Results
A statistically significant reduction in patient-reported pain scores was noted at 6 weeks after botulinum toxin injection (mean difference, 20.3; 95% confidence interval, 11.7–28.9) and continued past 12 weeks (mean difference, 19.4; 95% confidence interval, 14.6–24.2). Significant improvement was noted in secondary outcomes including dyspareunia, dyschezia, and quality of life.

Conclusions
This systematic review and meta-analysis support the conduct of future, large-scale randomized controlled trials to determine the efficacy and optimize administration of botulinum toxin injections for treatment of pelvic floor myofascial pain and associated symptoms in women.
Liver Transplantation in Patients With Pretransplant Aspergillus Colonization: Is It Safe to Proceed?
Authors: Amin Arpit , Molina Alfonso , Quach Lisa , Ito Takahiro , McMillan Robert , DiNorcia Joseph , Agopian Vatche G. , Kaldas Fady M. , Farmer Douglas G. , Busuttil Ronald W. , Winston Drew J. 
Published: April 2020

Background.
Patients with end-stage liver disease and pretransplant Aspergillus colonization are problematic for determining liver transplant candidacy and timing of transplantation because of concerns for posttransplant invasive aspergillosis.

Methods.
We performed a retrospective review of the medical and laboratory records of all adult patients (aged ≥18 y) who underwent liver transplantation with pretransplant Aspergillus colonization at the Ronald Reagan University of California, Los Angeles, Medical Center from January 1, 2010, to December 31, 2015.

Results.
A total of 27 patients who had Aspergillus colonization (respiratory tract 26, biliary tract 1) before liver transplantation were identified. Pretransplant characteristics included previous liver transplant (11 of 27, 40.7%), dialysis (22 of 27, 81.5%), corticosteroid therapy (12 of 27, 44.4%), intensive care unit stay (27 of 27, 100%), and median model for end-stage liver disease score of 39. Only 22.2% (6 of 27) received pretransplant antifungal agents (median duration, 5 d), whereas 100% (27 of 27) received posttransplant antifungal prophylaxis (voriconazole 81.4%, 22 of 27; echinocandin 14.8%, 4 of 27; voriconazole plus echinocandin 3.7%, 1 of 27) for median duration of 85 d. Posttransplant invasive fungal infection occurred in 14.8% (4 of 27; aspergillosis 3, mucormycosis 1). Both 6-month and 12-month survival were 66.7% (18 of 27), but only 1 death was due to fungal infection. Other causes of death were liver graft failure, intraabdominal complications, and malignancy.

Conclusions.
A substantial number of patients with pretransplant Aspergillus colonization can still undergo successful liver transplantation if they are otherwise suitable candidates and receive appropriate antifungal prophylaxis. Posttransplant outcome in these patients is determined mostly by noninfectious complications and not fungal infection. Pretransplant Aspergillus colonization alone should not necessarily preclude or delay liver transplantation.
Estimating the Final Epidemic Size for COVID-19 Outbreak using Improved Epidemiological Models
Authors: Ranjan Rajesh 
Published: April 2020

AbstractFinal epidemic sizes of different geographical regions due to COVID-19 are estimated using logistic, SIR and generalized SEIR models. These models use different parameters which are estimated using non-linear fits from the available data. It is found that both SIR and generalized SEIR models give similar estimations for regions where curves show signs of flattening. A study of these models with data from China indicates that in such cases these estimates may be more reliable. However, recent trend indicate that unlike China, the decline in infection rate for the US and other European countries is very slow, and does not follow a symmetric normal distribution. Hence a correction is introduced to account for this very slow decline based on the data from Italy. The estimates with all these models are presented for the most affected countries due to COVID-19. According to these models, the final epidemic size in the US, Italy, Spain, and Germany could be 1.1, 0.22, 0.24 and 0.19 million respectively. Also, it is expected that curves for most of the geographical regions will flatten by the middle of May 2020.
Proteomics of protein trafficking byin vivotissue-specific labeling
Authors: Droujinine Ilia A. , Wang Dan , Hu Yanhui , Udeshi Namrata D. , Mu Luye , Svinkina Tanya , Zeng Rebecca , Branon Tess , Tabatabai Areya , Bosch Justin A. , Asara John M. , Ting Alice Y. , Carr Steven A. , Perrimon Norbert 
Published: April 2020

AbstractSecreted interorgan communication factors encode key regulators of homeostasis. However, long-standing questions surround their origins/destinations, mechanisms of interactions, and the number of proteins involved. Progress has been hindered by the lack of methodologies for these factors’ large-scale identification and characterization, as conventional approaches cannot identify low-abundance factors and the origins and destinations of secreted proteins. We established anin vivoplatform to investigate secreted protein trafficking between organs proteome-wide, whereby engineered promiscuous biotin ligase BirA*G3 (a relative of TurboID) biotinylates all proteins in a subcellular compartment of one tissue, and biotinylated proteins are affinity-enriched and identified from distal organs using quantitative mass spectrometry. Using this platform, we identified 51 putative muscle-secreted proteins from heads and 269 fat body-secreted proteins from legs/muscles, of which 60-70% have human orthologs. We demonstrate, in particular, that conserved fat body-derived novel interorgan communication factors CG31326, CG2145, and CG4332 promote muscle activity. Our results indicate that the communication network of secreted proteins is vast, and we identified systemic functions for a number of these factors. This approach is widely applicable to studies in interorgan, local and intracellular protein trafficking networks, non-conventional secretion, and to mammalian systems, under healthy or diseased states.One Sentence SummaryWe developed anin vivoplatform to investigate protein trafficking between organs proteome-wide, provide a resource for interorgan communication factors, and determined conserved adipokines that affect muscles.
Human Ribosomal G-Quadruplexes Regulate Heme Bioavailability
Authors: Mestre-Fos Santi , Ito Chieri , Moore Courtney M. , Reddi Amit R. , Williams Loren Dean 
Published: April 2020

ABSTRACTThein vitroformation of stable G-quadruplexes (G4s) in human ribosomal RNA (rRNA) was recently reported. However, their formation in cells and their cellular roles have not been resolved. Here, by taking a chemical biology approach that integrates results from immunofluorescence, G4 ligands, heme affinity reagents, and a genetically encoded fluorescent heme sensor, we report that human ribosomes can form G4sin vivothat regulate heme bioavailability. Immunofluorescence experiments indicate that the vast majority of extra-nuclear G4s are associated with rRNA. Moreover, titrating human cells with a G4 ligand alters the ability of ribosomes to bind heme and disrupts cellular heme bioavailability as measured by a genetically encoded fluorescent heme sensor. Overall, these results suggest ribosomes are central hubs of heme metabolism.
Shareholder involvement and firm innovation performance
Authors: Zhang Feng , Zhu Lei , Wei Liqun 
Published: April 2020

PurposeWhether shareholders’ involvement in management benefits the organization’s performance remains inconclusive. The purpose of this study is to reconcile the conflicting results by exploring whether and under which contexts shareholder involvement may impact firm innovation performance.Design/methodology/approachThis study attempts to combine previous theoretical views (reactance and agency theories) to examine a curvilinear effect of shareholder involvement on firm innovation performance based on governance related to cost-benefit analysis. Drawing on data from 174 Chinese manufacturing firms, the hierarchical regressions were used to test the hypotheses.FindingsThe study finds that shareholder involvement has a U-shaped relationship with firm innovation performance. Moreover, ownership incentive strengthens the U-shaped relationship, while monitoring weakens it.Originality/valueExamination of the U-shaped main effect of shareholder involvement and these contingent factors further explains the mixed empirical results concerning the link between shareholder activism and firm-level performance.
How to perform strategic change? A strategy as practice perspective
Authors: Wei Zelong , Zhang Linqian 
Published: April 2020

PurposeIn spite of the significance of the strategic change, its high rate of failure inspires us to explore how to successfully enact new strategic change in a different environment. Based on strategy as practice perspective and effectuation theory, this study aims to extend extant literature by identifying two approaches performing strategic change (e.g. causation strategic change or effectuation strategic change) and investigating their effects on firm performance and also boundary conditions (e.g. market uncertainty or technological uncertainty).Design/methodology/approachBased on a data set from 238 firms in China, the authors empirically test the hypotheses through regression analysis.FindingsThe findings indicate that causation and effectuation strategic changes can promote firm performance. However, the roles of the two approaches vary with the external environment. Specifically, market uncertainty strengthens while technological uncertainty weakens the positive effect of causation strategic change. In contrast, technological uncertainty strengthens the positive effect of effectuation strategic change on firm performance.Originality/valueThis study extends research literature of strategic change by identifying causation and effectuation strategic changes and investigating how their roles vary with market uncertainty and technological uncertainty. The findings guide firms to adopt a fit approach to perform a strategic change in different external environments.
Magnetic shielding of a thin Al/steel/Al composite
Authors: Clérico Paul , Mininger Xavier , Prévond Laurent , Baudin Thierry , Helbert Anne-Laure 
Published: April 2020

Purpose
This paper aims to investigate the efficiency of a laminated composite for shielding applications. The solution has to be efficient not only for the shield against static magnetic fields but also “for low-frequency ones, in order to be well-suited for applications with electromagnetic perturbations in the frequency range DC to 100 kHz.”

Design/methodology/approach
The composite constituted of a steel sheet taken in a sandwich between two aluminum (Al) sheets is produced by cold roll bonding. A good adherence between Al and steel sheets, ensuring a good mechanical resistance, is obtained with a specific process. A previous study has shown that the optimal trade-off between adherence and magnetic shielding effectiveness (SEH) is obtained with a 230 µm composite produced with an initial thickness of Al and steel sheets, respectively, of 250 and 100 µm. In this paper, the 230 µm Al/steel/Al composite is used in three applications modelized by two-dimensional numerical simulations. To obtain reasonable computation time for the simulations, a homogenization method is applied to the composite. Studied applications are a cylindrical box containing a coil, a square box under an external magnetic field and a high voltage cable.

Findings
In each application, SEH is calculated at low frequency and different materials (Al/steel/Al, Al, steel and copper) are compared. It is observed that, in each application, the composite presents higher SEH at equal mass, especially for frequencies between 5 and 100 kHz.

Originality/value
The proposed approach, from the material point of view to the system consideration, shows that the thin bimetallic composite is an innovative and promising solution for magnetic shielding in the case of applications with both DC and low-frequency perturbations.
When affirmative action is not enough: challenges in career development of persons with disability
Authors: Gupta Amit , Priyadarshi Pushpendra 
Published: April 2020

PurposeThere is dearth of research pertaining to how persons with disability (PWDs) view their career and the issues they face in career development; past studies highlight either the organizational initiatives or individual factors in this regard. The present study bridges this gap by studying the PWDs' experiences and perceptions on challenges in their career development.Design/methodology/approachAn exploratory study through interview of professionally qualified PWDs in India, who have a permanent employment.FindingsPWDs experience that affirmative action has a negative fallout as it leads to positive discrimination and hence, adversely affects their confidence and development.Research limitations/implicationsThe present study throws up new themes in the organizational climate that the PWDs face in career development, future studies can understand the aspirations of PWDs toward career and focus on the how the PWDs engage in shaping their career. Researchers can explore strategies that PWDs plan/adopt in creating a sustainable career for themselves. Scholars can also map the issues raised by PWDs with the career outcomes.Social implicationsThe Rights of Persons with Disability Act, 2016, of Government of India introduces a social model of disability in India. This paper deploys the social model of disability to enhance our understanding of the disability climate in India from a new lens.Originality/valueThis study introduces new themes that depict the environmental factors and are related to the organizational climate rather than self-focused issues of PWDs. The paper introduces two new subjective criteria, voiced by PWDs, for career development – a well-crafted capability-based career path and role of inspirational platforms. It introduces hitherto undiscovered issues toward career development, faced by PWDs who have a secure employment and a professional career. This is the first exclusive study of PWDs employed in public sector and thus, brings uniqueness in the context.
Clarifying the disruptive innovation puzzle: a critical review
Authors: Martínez-Vergara Sucet Jimena , Valls-Pasola Jaume 
Published: April 2020

PurposeDisruptive innovation theory has attracted the interest of researchers and practitioners across many areas, resulting in the development of new business models and strategies. Despite the increasing scholarly attention, its definition has not yet been understood, the understanding of the term “disruptive” and the complex nature of this innovation has provoked some misinterpretations, and the meaning remains ambiguous. To address this confusion, this article undertakes a critical review of disruptive innovation in an attempt at providing a solid theoretical grounding.Design/methodology/approachThe review examines the key issues of published articles, identified after conducting a search in the Web of Science scholarly database. The analysis highlights the basic definitions of disruptive innovation, showing its evolution, types and its characteristics. This article also examines the behaviours adopted by the actors associated with disruptive innovation (i.e. incumbents, entrants and customers).FindingsOverall, this article finds that disruptive innovation has its own elements to be identified, requiring an in-depth analysis to avoid confusing with other innovation approaches. The findings suggest that disruptive innovation affects businesses and sectors in varied and complex ways because customers from low-end market and mainstream market appreciate this innovation. Further, its impact on practice is huge and incites further efforts in establishing a stronger theoretical grounding.Originality/valueOur research contributes on the evolution of this theory, helping to better understand the phenomenon of disruption and can be used for different types of research settings.
Parameters of ICT-associated deviant behaviour among Omani undergraduates
Authors: Al-Nuaimi Mariam Nasser , Bouazza Abdelmajid , Abu-Hilal Maher M. 
Published: April 2020

Purpose
This paper examines associations among the socio-psychological determinants of information and communication technologies (ICT)-assisted deviance-related practices within a group of Omani undergraduates. Moreover, this study aims to evaluate the explanatory burdens of such socio-psychological factors on actual behaviour.

Design/methodology/approach
The study implements a predictive research design applied to a cross-sectional sample. At the outset, a theoretical model was built based on the theory of planned behaviour (TPB). Thereafter, structural equation modelling was implemented to test the TPB model on the response data collected from a cluster sample of undergraduates from six universities in the Sultanate of Oman.

Findings
The results of the path diagram overwhelmingly support the TPB hypotheses. Specifically, intention is the most influential and immediate predictor of behaviour, while at the same time partially, though markedly, mediating the influence of cognition on behaviour.

Practical implications
This study has implications for the design of inclusive measures of the intrinsic dimensions of ethical self-efficacy as designated by the social cognitive theory of moral thought and conduct, which include moral judgment, self-monitoring of conduct and affective reactions to conduct. As the study reveals the importance of the explanatory power of cognition to explain variance in intention and behaviour, it has implications on the development of ICT-ethics-education.

Originality/value
This study fills a gap in the empirical literature on how intention mediates the relationship between ICT-ethics-connected cognition and behaviour. Moreover, the study addresses the direct relationship between cognition and behaviour – a relationship that is considered equivocal in both theories of planned behaviour and reasoned action.
A novel movies recommendation algorithm based on reinforcement learning with DDPG policy
Authors: Zhou Qiaoling 
Published: April 2020

PurposeEnglish original movies played an important role in English learning and communication. In order to find the required movies for us from a large number of English original movies and reviews, this paper proposed an improved deep reinforcement learning algorithm for the recommendation of movies. In fact, although the conventional movies recommendation algorithms have solved the problem of information overload, they still have their limitations in the case of cold start-up and sparse data.Design/methodology/approachTo solve the aforementioned problems of conventional movies recommendation algorithms, this paper proposed a recommendation algorithm based on the theory of deep reinforcement learning, which uses the deep deterministic policy gradient (DDPG) algorithm to solve the cold starting and sparse data problems and uses Item2vec to transform discrete action space into a continuous one. Meanwhile, a reward function combining with cosine distance and Euclidean distance is proposed to ensure that the neural network does not converge to local optimum prematurely.FindingsIn order to verify the feasibility and validity of the proposed algorithm, the state of the art and the proposed algorithm are compared in indexes of RMSE, recall rate and accuracy based on the MovieLens English original movie data set for the experiments. Experimental results have shown that the proposed algorithm is superior to the conventional algorithm in various indicators.Originality/valueApplying the proposed algorithm to recommend English original movies, DDPG policy produces better recommendation results and alleviates the impact of cold start and sparse data.