bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oestrogens in milk and breast cancer: a cause for concern…or not?
Authors: Peaker Malcolm 
Published: May 2020

AbstractIn this short Research Reflection I address and refute the suggestion that oestrogens consumed in milk might contribute in a significant way to endogenous levels and thereby have a physiological action, possibly resulting in adverse consequences including increased breast cancer risk. Quantitative analysis based on published data shows that, even in worst case scenarios, oestrogen consumption in milk is considerably less than regulatory bodies regard as entirely safe.
Determining the ideal prevention strategy for multidrug-resistance organisms in resource-limited countries: a cost-effectiveness analysis study
Authors: Wang Ying , Yuan Yufeng , Lin Likai , Tan Xiaodong , Tan Yibin 
Published: May 2020

Abstract
The aim of this study was to determine the most cost-effective strategy for the prevention and control of multidrug-resistant organisms (MDROs) in intensive care units (ICUs) in areas with limited health resources. The study was conducted in 12 ICUs of four hospitals. The total cost for the prevention of MDROs and the secondary attack rate (SAR) of MDROs for each strategy were collected retrospectively from 2046 subjects from January to December 2017. The average cost-effectiveness ratio (CER), incremental cost-effectiveness ratio (ICER) and cost-effectiveness acceptability curve were calculated. Hand hygiene (HH) had the lowest total cost (2149.6 RMB) and SAR of MDROs (8.8%) while single-room isolation showed the highest cost (33 700.2 RMB) and contact isolation had the highest SAR of MDROs (31.8%). The average cost per unit infection prevention was 24 427.8 RMB, with the HH strategy followed by the environment disinfection strategy (CER = 21 314.67). HH had the highest iterative cost effect under willingness to pay less than 2000 RMB. Due to the low cost for repeatability and obvious effectiveness, we conclude that HH is the optimal strategy for MDROs infections in ICUs in developing countries. The cost-effectiveness of the four prevention strategies provides some reference for developing countries but multiple strategies remain to be examined.
Empathy and Theory of Mind in Alzheimer’s Disease: A Meta-analysis
Authors: Demichelis Olivia P. , Coundouris Sarah P. , Grainger Sarah A. , Henry Julie D. 
Published: May 2020

AbstractObjective:A large literature now shows that Alzheimer’s disease (AD) disrupts a number of social cognitive abilities, including social perceptual function and theory of mind (ToM). However, less well understood is how the specific subcomponents of ToM as well as both the broader and specific subcomponents of empathic processing are affected.Method:The current study provides the first meta-analytic review of AD that focuses on both empathy and ToM as broad constructs, as well as their overlapping (cognitive empathy and affective ToM) and distinct (affective empathy and cognitive ToM) subcomponents.Results:Aggregated across 31 studies, the results revealed that, relative to controls, AD is associated with large-sized deficits in both cognitive ToM (g= 1.09) and affective ToM/cognitive empathy (g= 0.76). However, no statistical differences were found between the AD participants and controls on affective empathic abilities (g= 0.36).Conclusions:These data point to a potentially important disconnect between core aspects of social cognitive processing in people with AD. The practical and theoretical implications of these findings are discussed.
Symptombezogene Subgruppen von Patienten mit agoraphobischer Angst
Authors: Hoferichter Esther , Schmidt Ruth , Höfler Michael , Hoyer Jürgen , Rottstädt Fabian , Weidner Kerstin , Noack René 
Published: May 2020

Zusammenfassung. Theoretischer Hintergrund: Bisher ist wenig über symptombezogene Teilgruppen von Patient_innen mit agoraphobischer Angst über die Betrachtung als mit oder ohne Panikstörung hinausgehend bekannt. So sind existierende Behandlungsprogramme meist nicht modularisiert und berücksichtigen die möglicherweise vorhandenen spezifischen Bedarfe kaum. Daher untersuchten wir die Frage, welche Subgruppen anhand von symptombezogenen Variablen identifiziert werden können. Methode: N = 290 Patient_innen mit SKID-Diagnose Agoraphobie mit oder ohne Panikstörung, in einer auf die Behandlung von Angststörungen spezialisierten universitären Tagesklinik, wurden anhand von Skalenwerten des Fragebogens zu angstbezogenen Kognitionen (ACQ) sowie der Panik- und Agoraphobie-Skala (PAS) mittels einer Clusteranalyse nach dem Ward-Verfahren mit anschließender k-means-Optimierung nach inhaltlicher Interpretierbarkeit gruppiert. Die Validität wurde am externen Kriterium „Therapieerfolg“ geprüft. Ergebnisse: Neben zwei Subgruppen mit sehr hoher ( n = 67) und sehr niedriger ( n = 56) Symptomausprägung auf sämtlichen Skalen, wurden zwei qualitativ-symptomatisch differentielle Subtypen identifiziert: der Typus „Körperliche Befürchtungen“ ( n = 81) und der Typus „Verhaltenskontrollverlust“ ( n = 86). Letztere zeigten keine Unterschiede im Therapieerfolg. Schlussfolgerungen: Die Identifikation spezifischer Patient_innengruppen impliziert spezifische Therapiebedarfe und -erwartungen über das Vorliegen einer Paniksymptomatik hinaus. Es zeigte sich, dass der individuellen agoraphobischen Befürchtung bei den unterschiedlichen Patient_innengruppen besondere Bedeutung zukommt, weswegen diese bei der Therapieplanung besondere Beachtung erfahren sollte.
Contact With Gay Men and Lesbian Women Moderates the Negative Relationship Between Religiosity and Endorsement of Same-Sex Unions’ and Families’ Rights
Authors: Piumatti Giovanni , Salvati Marco 
Published: May 2020

Abstract. This study investigated the moderation effect of contact with gay men and lesbian women on the relationship between religiosity levels with the endorsement of same-sex unions’ and families’ rights. Analyses were carried out on a national representative cross-sectional sample of 5,544 Italian adult residents (% females = 54). Multiple linear regressions coupled with an examination of the interaction between contact and religiosity showed that contact mitigated the negative relationship between religiosity and endorsement of same-sex unions’ and families’ rights, especially at lower rather than higher levels of religiosity. These results are important in terms of understandings of the relationship between religiosity and policy preference regarding same-sex unions’ and families’ rights. Contact can promote equality for gay men and lesbian women but different susceptibility levels persist between highly and less religious individuals in this respect.
Spatial and Temporal Evolution of Different‐Scale Ionospheric Irregularities in Central and East Siberia During the 27–28 May 2017 Geomagnetic Storm
Authors: Ovodenko V. B. , Klimenko M. V. , Zakharenkova I. E. , Oinats A. V. , Kotova D. S. , Nikolaev A. V. , Tyutin I. V. , Rogov D. D. , Ratovsky K. G. , Chugunin D. V. , Budnikov P. A. , Coxon J. C. , Anderson B. J. , Chernyshov A. A. 
Published: May 2020

AbstractWe present a multi‐instrumental study of ionospheric irregularities of different scales (from tens of centimeters to few kilometers) observed over the Central and East Siberia, Russia, during a moderate‐to‐strong geomagnetic storm on 27–28 May 2017. From high‐frequency (HF) and ultrahigh‐frequency (UHF) radar data, we observed an intense auroral backscatter developed right after the initial phase of the geomagnetic storm. Additionally, we examined variations of Global Positioning System (GPS)‐based ROT (rate of TEC changes, where TEC is total electron content) for available GPS receivers in the region. Ionosondes, HF, and UHF radar data exhibited a presence of intense multi‐scale ionospheric irregularities. We revealed a correlation between different‐scale Auroral/Farley‐Buneman ionospheric irregularities of the E layer during the geomagnetic storm. The combined analysis showed that an area of intense irregularities is well connected and located slightly equatorward to field‐aligned currents (FACs) and auroral oval at different stages of the geomagnetic storm. An increase and equatorward displacement of Region 1 (R1)/Region 2 (R2) FACs leads to appearance and equatorward expansion of ionospheric irregularities. During downward (upward) R1 FAC and upward (downward) R2 FAC, the eastward and upward (westward and downward) E × B drift of ionospheric irregularities occurred. Simultaneous disappearance of UHF/HF auroral backscatter and GPS ROT decrease occurred during a prolonged near noon reversal of R1 and R2 FAC directions that accompanied by R1/R2 FAC degradation and disappearance of high‐energy auroral precipitation.
Curbing the Summer Surge: Permanent Outdoor Water Use Restrictions in Humid and Semiarid Cities
Authors: Finley Sara L. , Basu Nandita B. 
Published: May 2020

AbstractAs urban droughts make headlines across the globe, it is increasingly relevant to critically evaluate the long‐term sustainability of both water supply and demand in the world's cities. This is the case even in water‐rich regions, where upward swings in water demands during periods of hot, dry weather can aggravate already strained water supplies and increase cities' vulnerability to water shortage. Summer spikes in water demand have motivated several cities to impose permanent restrictions on outdoor water uses; however, little is yet known about their effectiveness. This paper examines daily water production data from 15 Canadian cities to (1) quantify how overall and seasonal demands are evolving over time across humid and semiarid settings and (2) determine whether permanent water use restrictions have been effective in curbing summer water demands both seasonally and during specific hot and dry periods. Results show that while per‐capita water demand is declining in all cities studied, the seasonal distribution of that demand has remained largely stable in all but a few cases. While average demands in the summer months remain largely unaffected by the imposition of permanent restrictions, cities that enforce stringent limits on outdoor water use have seen a reduction in the variability of daily demands and a decline in peak demands following their implementation. During short‐term periods of exceptionally hot and dry weather when vulnerability to water shortage is most acute, cities with strict restrictions also see smaller surges in demand than those with weaker or no restrictions in place.
Floodplain Inundation and Salinization From a Recently Restored First‐Order Tidal Stream
Authors: Yabusaki Steven B. , Myers‐Pigg Allison N. , Ward Nicholas D. , Waichler Scott R. , Sengupta Aditi , Hou Zhangshuan , Chen Xingyuan , Fang Yilin , Duan Zhuoran , Serkowski John A. , Indivero Julia , Wiese Moore Cora , Gunn Cailene M. 
Published: May 2020

AbstractThe systematic response of coastal ecosystems to inundation and salinity exposure is fundamental to their ecology and biogeochemical function. Here we observe and model freshwater‐seawater interactions in a first‐order stream—floodplain system where tidal access was recently restored. Subsurface flow and transport modeling were used to quantify and better understand the interplay of processes, properties, and conditions that control water level and salinity in the floodplain to the tidal stream. Water levels in the stream were highly correlated with tidal forcing, which resulted in episodic inundation of the floodplain at quasi‐monthly frequency. The tidal stream is the only source of salinity to the floodplain, yet shallow groundwater salinity was considerably higher than average stream salinity. The low‐permeability clay floodplain soils limit lateral groundwater flow and transport, resulting in floodplain groundwater and salinity dynamics driven almost exclusively by infiltration during inundation events. As inundation occurs during high tide, estuarine waters reach the floodplain with minor attenuation in salinity from the stream's freshwater discharge. Infiltration and salinity exposure are topography controlled and regulated by ponding depth and duration, seasonal ground saturation, and depth to water table. The model suggests that floodplain salinity is currently in an early stage of transition from pre‐restoration freshwater conditions and will not reach equilibrium for ~20 years. These findings have broad relevance for understanding how and over what time scales coastal ecosystems will respond to increasing seawater exposure from sea level rise, ocean‐originating storms, and changes in natural and man‐made barriers.
A New Method to Construct a Horizontal Resolution‐Dependent Wind Speed Adjustment Factor for Tropical Cyclones in Global Climate Model Simulations
Authors: Moon Yumin , Kim Daehyun , Camargo Suzana J. , Wing Allison A. , Reed Kevin A. , Wehner Michael F. , Zhao Ming 
Published: May 2020

AbstractA new method to construct a horizontal resolution‐dependent wind speed adjustment factor for evaluating tropical cyclones (TCs) in global climate models (GCMs) is presented. In contrast to the previous studies that used idealized axisymmetric wind fields, this study analyzes 48 hr of 10‐s surface wind fields from 1‐km TC simulations. The adjustment factor is derived from filtering the simulated TC wind fields onto various horizontal grid spacings typical of those used in GCMs. The new adjustment factor leads to TCs with greater intensity than the existing adjustment factors for horizontal grid spacings smaller than 30 km. This difference is attributed to more realistic wind fields in the TC simulations that contain highly asymmetric, localized patches of higher wind speeds instead of axisymmetric wind fields. Applying the new adjustment factor to select GCM simulations suggests the common interpretation of low‐intensity bias in GCM‐simulated TCs might be slightly exaggerated.
Four Atmospheric Circulation Regimes Over the North Pacific and Their Relationship to California Precipitation on Daily to Seasonal Timescales
Authors: Guirguis Kristen , Gershunov Alexander , DeFlorio Michael J. , Shulgina Tamara , Delle Monache Luca , Subramanian Aneesh C. , Corringham Thomas W. , Ralph F. Martin 
Published: May 2020

AbstractPrecipitation in California is highly variable and not well forecasted on subseasonal‐to‐seasonal (S2S) timescales. Understanding relationships between synoptic‐scale atmospheric circulation and hydrometeorological extremes could improve predictability. This work demonstrates the importance of four North Pacific circulation regimes (called the NP4 modes) in modulating precipitation, flooding, and water resources in California. Here we demonstrate how, on daily timescales, interactions between the NP4 modes drive coastal flow that can result in dry conditions from atmospheric ridging or wet conditions associated with enhanced onshore flow and atmospheric river (AR) landfalls. Seasonally, the prevalence of certain NP4 phase relationships can tip the scale toward wet or dry conditions. Relationships between El Niño Southern Oscillation (ENSO) and the NP4 are explored, and we provide insight into the poorly forecasted Western US seasonal precipitation during the “Godzilla” El Niño winter of 2016 by examining climate‐weather linkages in a historical context.
Characteristics of the Prolonged El Niño Events During 1960–2020
Authors: Lee Chung‐Wei , Tseng Yu‐Heng , Sui Chung‐Hsiung , Zheng Fei , Wu Erh‐Tung 
Published: May 2020

AbstractMost El Niño events decayed rapidly after boreal winter, while some events prolonged and grew again in the second year, accounting for 5 out of the 17 episodes during 1960–2020. In their development stages, warm water volume (WWV) anomalies were comparable to the other events, but the growth of sea surface temperature (SST) and westerly anomalies and the discharge of WWV were delayed by about a season. The weak but warm SST anomaly in Eastern Pacific persisted into next year, intensified again via Bjerknes feedback, and decayed after the second boreal winter. In June–October of 1968, 1986, 2014, and 2018, a strengthened cross‐hemisphere SST gradient appeared in Eastern Pacific, induced anomalous southerly at the equator, and disrupted the zonal positive feedback. The intensity of this meridional mode is independent of the El Niño state and is weaker in late 1990s to early 2010s than in other decades.
Interaction between microbiota and immunity in health and disease
Authors: Zheng Danping , Liwinski Timur , Elinav Eran 
Published: May 2020

AbstractThe interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and disease. The microbiome plays critical roles in the training and development of major components of the host’s innate and adaptive immune system, while the immune system orchestrates the maintenance of key features of host-microbe symbiosis. In a genetically susceptible host, imbalances in microbiota-immunity interactions under defined environmental contexts are believed to contribute to the pathogenesis of a multitude of immune-mediated disorders. Here, we review features of microbiome-immunity crosstalk and their roles in health and disease, while providing examples of molecular mechanisms orchestrating these interactions in the intestine and extra-intestinal organs. We highlight aspects of the current knowledge, challenges and limitations in achieving causal understanding of host immune-microbiome interactions, as well as their impact on immune-mediated diseases, and discuss how these insights may translate towards future development of microbiome-targeted therapeutic interventions.
Precise coupling of the thalamic head-direction system to hippocampal ripples
Authors: Viejo Guillaume , Peyrache Adrien 
Published: May 2020

AbstractThe anterior thalamus is a key relay of neuronal signals within the limbic system. During sleep, the occurrence of hippocampal sharp wave-ripples (SWRs), believed to mediate consolidation of explicit memories, is modulated by thalamocortical network activity, yet how information is routed around SWRs and how this communication depends on neuronal dynamics remains unclear. Here, by simultaneously recording ensembles of neurons in the anterior thalamus and local field potentials in the CA1 area of the hippocampus, we show that the head-direction (HD) cells of the anterodorsal nucleus are set in stable directions immediately before SWRs. This response contrasts with other thalamic cells that exhibit diverse couplings to the hippocampus related to their intrinsic dynamics but independent of their anatomical location. Thus, our data suggest a specific and homogeneous contribution of the HD signal to hippocampal activity and a diverse and cell-specific coupling of non-HD neurons.
In-situ structure and catalytic mechanism of NiFe and CoFe layered double hydroxides during oxygen evolution
Authors: Dionigi Fabio , Zeng Zhenhua , Sinev Ilya , Merzdorf Thomas , Deshpande Siddharth , Lopez Miguel Bernal , Kunze Sebastian , Zegkinoglou Ioannis , Sarodnik Hannes , Fan Dingxin , Bergmann Arno , Drnec Jakub , Araujo Jorge Ferreira de , Gliech Manuel , Teschner Detre , Zhu Jing , Li Wei-Xue , Greeley Jeffrey , Cuenya Beatriz Roldan , Strasser Peter 
Published: May 2020

AbstractNiFe and CoFe (MFe) layered double hydroxides (LDHs) are among the most active electrocatalysts for the alkaline oxygen evolution reaction (OER). Herein, we combine electrochemical measurements, operando X-ray scattering and absorption spectroscopy, and density functional theory (DFT) calculations to elucidate the catalytically active phase, reaction center and the OER mechanism. We provide the first direct atomic-scale evidence that, under applied anodic potentials, MFe LDHs oxidize from as-prepared α-phases to activated γ-phases. The OER-active γ-phases are characterized by about 8% contraction of the lattice spacing and switching of the intercalated ions. DFT calculations reveal that the OER proceeds via a Mars van Krevelen mechanism. The flexible electronic structure of the surface Fe sites, and their synergy with nearest-neighbor M sites through formation of O-bridged Fe-M reaction centers, stabilize OER intermediates that are unfavorable on pure M-M centers and single Fe sites, fundamentally accounting for the high catalytic activity of MFe LDHs.
Finding the equilibrium of organic electrochemical transistors
Authors: Kaphle Vikash , Paudel Pushpa Raj , Dahal Drona , Radha Krishnan Raj Kishen , Lüssem Björn 
Published: May 2020

AbstractOrganic Electrochemical Transistors are versatile sensors that became essential for the field of organic bioelectronics. However, despite their importance, an incomplete understanding of their working mechanism is currently precluding a targeted design of Organic Electrochemical Transistors and it is still challenging to formulate precise design rules guiding materials development in this field. Here, it is argued that current capacitive device models neglect lateral ion currents in the transistor channel and therefore fail to describe the equilibrium state of Organic Electrochemical Transistors. An improved model is presented, which shows that lateral ion currents lead to an accumulation of ions at the drain contact, which significantly alters the transistor behavior. Overall, these results show that a better understanding of the interface between the organic semiconductor and the drain electrode is needed to reach a full understanding of Organic Electrochemical Transistors.
Arene dearomatization through a catalytic N-centered radical cascade reaction
Authors: McAtee Rory C. , Noten Efrey A. , Stephenson Corey R. J. 
Published: May 2020

AbstractArene dearomatization reactions are an important class of synthetic technologies for the rapid assembly of unique chemical architectures. Herein, we report a catalytic protocol to initiate a carboamination/dearomatization cascade that proceeds through transient sulfonamidyl radical intermediates formed from native sulfonamide N–H bonds leading to 1,4-cyclohexadiene-fused sultams. Importantly, this work demonstrates a facile approach to employ two-dimensional aromatic compounds as modular building blocks to generate richly substituted, three-dimensional compounds. These reactions occur at room temperature under visible light irradiation and are catalyzed by the combination of an iridium(III) photocatalyst and a dialkyl phosphate base. Reaction optimization, substrate scope, mechanistic features, and synthetic applications of this transformation are presented.
CeutaOPEN, individual-based field observations of breeding snowy plovers Charadrius nivosus
Authors: Eberhart-Phillips Luke J. , Cruz-López Medardo , Lozano-Angulo Lydia , del Ángel Salvador Gómez , Rojas-Abreu Wendoly , Bucio-Pacheco Marcos , Küpper Clemens 
Published: May 2020

AbstractShorebirds (part of the order Charadriiformes) have a global distribution and exhibit remarkable variation in ecological and behavioural traits that are pertinent to many core questions in the fields of evolutionary ecology and conservation biology. Shorebirds are also relatively convenient to study in the wild as they are ground nesting and often occupy open habitats that are tractable to monitor. Here we present a database documenting the reproductive ecology of 1,647 individually marked snowy plovers (Charadrius nivosus) monitored between 2006 and 2016 at Bahía de Ceuta (23°54N, 106°57W) – an important breeding site in north-western Mexico. The database encompasses various morphological, behavioural, and fitness-related traits of males and females along with spatial and temporal population dynamics. This open resource will serve as an important data repository for addressing overarching questions in avian ecology and wetland conservation during an era of big data and global collaborative science.