bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pazopanib and Oral Cyclophosphamide in Women With Platinum-Resistant or -Refractory Epithelial Ovarian Cancer
Authors: Gulia Seema , Ghosh Jaya , Bajpai Jyoti , Rath Sushmita , Maheshwari Amita , Shylasree T.S. , Deodhar Kedar , Thakur Meenakshi , Gupta Sudeep 
Published: March 2020

PURPOSE Women with recurrent, multiply-treated epithelial ovarian cancer (EOC) have unfavorable prognosis with limited treatment options after failure of platinum-based regimens. We report here a retrospective analysis of women with recurrent, platinum-resistant EOC treated with an oral regimen of pazopanib and cyclophosphamide. PATIENTS AND METHODS Women with recurrent platinum-resistant or -refractory EOC were treated with pazopanib (600 mg orally daily in 2 divided doses, 400 and 200 mg) and cyclophosphamide (50 mg orally daily for 21 days every 28 days) until disease progression or unacceptable toxicity. RESULTS Twenty patients (17 with platinum-resistant and 3 with platinum-refractory disease) were treated between April 2014 and April 2018. Patients had a median age of 52 years (range, 40-60 years) and median of 4 previous lines of chemotherapy (range, 2-8 previous lines), including 3 patients with progressive disease on bevacizumab. Patients received a median of 6 cycles (range, 2-48 cycles) of pazopanib and cyclophosphamide, with best responses of partial response in 9 patients (45%, including 1 of 3 patients treated previously with bevacizumab), stable disease in 6 patients (30%), and disease progression in 5 patients (25%). The median progression-free survival time was 5.5 months, and median overall survival was 9.5 months. Common adverse events (grade 3 or 4) were fatigue (25%), diarrhea (15%), hand-foot syndrome (10%), mucositis (10%), transaminitis (5%), and hypertension (5%). Dose reduction as a result of toxicity was required in 14 patients (70%), and no patient stopped treatment as a result of toxicity. CONCLUSION Pazopanib plus oral cyclophosphamide is a well-tolerated regimen with clinically relevant benefit in patients with platinum-resistant or -refractory EOC.
The Final Bows
Authors: Hume Sara 
Published: March 2020

AbstractHow did people actually dress across rural Alsace from the late nineteenth to the early twentieth century? The image that fills the popular imagination of Alsatian dress during this period is of a regional costume, including a large head bow. This stereotype was developed and reinforced by intellectuals who documented and preserved these disappearing styles. The survival of this static folk dress obscures the actual transformation of regional dress into styles that more closely resembled those worn in urban areas. This study looks at rural costume in Alsace to understand its transition from distinctive regional dress into styles more in line with urban styles, by making use of a range of source material, including notarial acts, surviving garments preserved in museum collections, and photographs of weddings and other religious ceremonies.Comment s'habillaient les gens en Alsace rurale de la fin du dix-neuvième au début du vingtième siècle ? L'image qui nous vient tout de suite à l'esprit est celle du grand nœud noir. Ce stéréotype a été développé et renforcé par les intellectuels qui ont documenté et préservé ces modes en voie de disparition. La survivance de ce costume folklorique cache cependant la transformation qu'ont connue les habits régionaux, sous l'influence des vêtements portés en ville. Cet article étudie le costume rural en Alsace pour mieux comprendre comment s'est réalisée la transition des vêtements régionaux en vêtements dont le style était plus conforme à celui des villes. Pour ce faire, il utilise une variété de sources, y compris les actes notariés, les vêtements préservés dans les collections des musées, et les photographies de mariages et d'autres cérémonies religieuses.
Antioxidant (gallic acid and quercetin) profile of Sumatran wild mangoes (Mangifera spp.): a potential source for antidegenerative medicine
Authors: Fitmawati Fitmawati , Resida Esi , Kholifah Sri Nur , Roza Rodesia Mustika , Almurdani Muhammad , Emrizal Emrizal 
Published: March 2020

Background: New findings on the potential of wild mangoes from the island of Sumatra as a source of antioxidant helps their conservation effort as it introduces their useful compounds to the public. This study aims to analyze the antioxidant profile and quantification of gallic acid and quercetin content from leaves and bark of Sumatran wild mangoes. Exploration and analysis of phytochemical constituents from 11 Sumatran wild mangoes was performed. Methods: Antioxidant activity of wild mangoes was analysed with 1,1- diphenyl-2-picryl hydroxyl (DPPH), and determination of quercetin and gallic acid content was performed by high performance liquid chromatography (HPLC) method. Total flavonoid and phenolic analysis was also performed. Curve fitting analysis used a linear regression approach. Results: The highest level of antioxidant activity, phenolic compound and flavonoid compound was found in the leaves and bark of Mangifera sp1. (MBS), the bark of M. foetida3 (var. batu) and leaves of M. torquenda, and the bark and leaves of M. sumatrana, respectively. The content of gallic acid in leaves ranged from 5.2270-35.4763 mg/g dry weight. Quercetin content of wild mangoes leaves ranged from 0.76 to 1.47 mg/g dry weight with the lowest value in M. foetida2 (var. manis) and the highest in M. laurina. Conclusion: The results obtained are expected to be useful in supporting the development of antidegenerative drugs from natural ingredients that have potential as immunomodulatory agents.
Generalized mean p-values for combining dependent tests: comparison of generalized central limit theorem and robust risk analysis
Authors: Wilson Daniel J. 
Published: March 2020

The test statistics underpinning several methods for combining p-values are special cases of generalized mean p-value (GMP), including the minimum (Bonferroni procedure), harmonic mean and geometric mean. A key assumption influencing the practical performance of such methods concerns the dependence between p-values. Approaches that do not require specific knowledge of the dependence structure are practically convenient. Vovk and Wang derived significance thresholds for GMPs under the worst-case scenario of arbitrary dependence using results from Robust Risk Analysis (RRA). Here I calculate significance thresholds and closed testing procedures using Generalized Central Limit Theorem (GCLT). GCLT formally assumes independence, but enjoys a degree of robustness to dependence. The GCLT thresholds are less stringent than RRA thresholds, with the disparity increasing as the exponent of the GMP (r) increases. I motivate a model of p-value dependence based on a Wishart-Multivariate-Gamma distribution for the underlying log-likelihood ratios. In simulations under this model, the RRA thresholds produced tests that were usually less powerful than Bonferroni, while the GCLT thresholds produced tests more powerful than Bonferroni, for all r> − ∞. Above r> − 1, the GCLT thresholds suffered pronounced false positive rates. Above r> − 1/2, standard central limit theorem applied and the GCLT thresholds no longer possessed any useful robustness to dependence. I consider the implications of these results in the context of various interpretations of GMPs, and conclude that the GCLT-based harmonic mean p-value procedure and Simes' (1986) test represent good compromises in power-robustness trade-off for combining dependent tests.
Varus-valgus constraint in 416 revision total knee arthroplasties with cemented stems provides a reliable reconstruction with a low subsequent revision rate at early to mid-term review
Authors: Limberg Afton K , Tibbo Meagan E , Pagnano Mark W , Perry Kevin I , Hanssen Arlen D , Abdel Matthew P 
Published: March 2020

AimsVarus-valgus constrained (VVC) implants are often used during revision total knee arthroplasty (TKA) to gain coronal plane stability. However, the increased mechanical torque applied to the bone-cement interface theoretically increases the risk of aseptic loosening. We assessed mid-term survivorship, complications, and clinical outcomes of a fixed-bearing VVC device in revision TKAs.MethodsA total of 416 consecutive revision TKAs (398 patients) were performed at our institution using a single fixed-bearing VVC TKA from 2007 to 2015. Mean age was 64 years (33 to 88) with 50% male (199). Index revision TKA diagnoses were: instability (n = 122, 29%), aseptic loosening (n = 105, 25%), and prosthetic joint infection (PJI) (n = 97, 23%). All devices were cemented on the epiphyseal surfaces. Femoral stems were used in 97% (n = 402) of cases, tibial stems in 95% (n = 394) of cases; all were cemented. In total, 93% (n = 389) of cases required a stemmed femoral and tibial component. Femoral cones were used in 29%, and tibial cones in 40%. Survivorship was assessed via competing risk analysis; clinical outcomes were determined using Knee Society Scores (KSSs) and range of movement (ROM). Mean follow-up was four years (2 to 10).ResultsThe five-year cumulative incidence of subsequent revision for aseptic loosening and instability were 2% (95% confidence interval (CI) 0.2 to 3, number at risk = 154) and 4% (95% CI 2 to 6, number at risk = 153), respectively. The five-year cumulative incidence of any subsequent revision was 14% (95% CI 10 to 18, number at risk = 150). Reasons for subsequent revision included PJI (n = 23, of whom 12 had previous PJI), instability (n = 13), and aseptic loosening (n = 11). The use of this implant without stems was found to be a significant risk factor for subsequent revision (hazard ratio (HR) 7.58 (95% CI 3.98 to 16.03); p = 0.007). KSS improved from 46 preoperatively to 81 at latest follow-up (p < 0.001). ROM improved from 96° prerevision to 108° at latest follow-up (p = 0.016).ConclusionThe cumulative incidence of subsequent revision for aseptic loosening and instability was very low at five years with this fixed-bearing VVC implant in revision TKAs. Routine use of cemented and stemmed components with targeted use of metaphyseal cones likely contributed to this low rate of aseptic loosening. Cite this article: Bone Joint J 2020;102-B(4):458–462.
How should we evaluate robotics in the operating theatre?
Authors: Vermue Hannes , Lambrechts Jasper , Tampere Thomas , Arnout Nele , Auvinet Edouard , Victor Jan 
Published: March 2020

The application of robotics in the operating theatre for knee arthroplasty remains controversial. As with all new technology, the introduction of new systems might be associated with a learning curve. However, guidelines on how to assess the introduction of robotics in the operating theatre are lacking. This systematic review aims to evaluate the current evidence on the learning curve of robot-assisted knee arthroplasty. An extensive literature search of PubMed, Medline, Embase, Web of Science, and Cochrane Library was conducted. Randomized controlled trials, comparative studies, and cohort studies were included. Outcomes assessed included: time required for surgery, stress levels of the surgical team, complications in regard to surgical experience level or time needed for surgery, size prediction of preoperative templating, and alignment according to the number of knee arthroplasties performed. A total of 11 studies met the inclusion criteria. Most were of medium to low quality. The operating time of robot-assisted total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) is associated with a learning curve of between six to 20 cases and six to 36 cases respectively. Surgical team stress levels show a learning curve of seven cases in TKA and six cases for UKA. Experience with the robotic systems did not influence implant positioning, preoperative planning, and postoperative complications. Robot-assisted TKA and UKA is associated with a learning curve regarding operating time and surgical team stress levels. Future evaluation of robotics in the operating theatre should include detailed measurement of the various aspects of the total operating time, including total robotic time and time needed for preoperative planning. The prior experience of the surgical team should also be evaluated and reported. Cite this article: Bone Joint J 2020;102-B(4):407–413.
Evaluation of synovial fluid neutrophil CD64 index as a screening biomarker of prosthetic joint infection
Authors: Qin Leilei , Hu Ning , Li Xinyu , Chen Yuelong , Wang Jiawei , Huang Wei 
Published: March 2020

Aims Prosthetic joint infection (PJI) remains a major clinical challenge. Neutrophil CD64 index, Fc-gamma receptor 1 (FcγR1), plays an important role in mediating inflammation of bacterial infections and therefore could be a valuable biomarker for PJI. The aim of this study is to compare the neutrophil CD64 index in synovial and blood diagnostic ability with the standard clinical tests for discrimination PJI and aseptic implant failure. Methods A total of 50 patients undergoing revision hip and knee arthroplasty were enrolled into a prospective study. According to Musculoskeletal Infection Society (MSIS) criteria, 25 patients were classified as infected and 25 as not infected. In all patients, neutrophil CD64 index and percentage of polymorphonuclear neutrophils (PMN%) in synovial fluid, serum CRP, ESR, and serum CD64 index levels were measured preoperatively. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were analyzed for each biomarker. Results Serum CD64 index showed no significant difference between the two groups (p = 0.091). Synovial fluid CD64 index and PMN% discriminated good differentiation between groups of PJI and aseptic failure with AUC of 0.946 (95% confidence interval (CI) 0.842 to 0.990) and 0.938 (95% CI 0.832 to 0.987) separately. The optimal threshold value of synovial CD64 index for the diagnosis of PJI was 0.85, with a sensitivity of 92.00%, a specificity of 96.00%, and diagnostic odds ratio (DOR) of 227.11. Conclusion The present study demonstrates that CD64 index in synovial fluid could be a promising laboratory marker for screening PJI. The cut-off values of 0.85 for synovial CD64 index has the potential to distinguish aseptic failure from PJI. Cite this article: Bone Joint J 2020;102-B(4):463–469.
Comparative and competitive advantages of nutmeg farming in two regions in Maluku Province, Indonesia
Authors: Simanjorang Tienni , Irham  , Waluyati Lestari Rahayu , Mulyo Jangkung Handoyo 
Published: March 2020

Abstract. Simanjorang TM, Irham, Waluyati LR, Mulyo JH. 2020. Comparative and competitive advantages of nutmeg farming in two regions in Maluku Province, Indonesia. Biodiversitas 21: 1165-1173. Comparative and competitive advantage is one of the main keys to the development of nutmeg farming in Maluku Province to deal with globalization and market liberalization. Consequently, assessments are needed in developing efforts to improve the comparative and competitive advantage of nutmeg farming. The purposes of this study are to find out the private and social benefits of nutmeg farming, to find out the comparative and competitive advantages of nutmeg farming, and to compare the level of competitiveness of small-scale nutmeg farming in two regions in Maluku Province, Indonesia, namely the Ambon Island region and the Banda Islands region. Data were collected using direct interview techniques to smallholder nutmeg farmers selected purposively. The data was then analyzed using the Policy Analysis Matrix (PAM) and the t-independent test of difference. The results show that nutmeg farming in the Banda Islands region has higher private and social benefits than in the Ambon Island region, because the nutmeg farming system in Banda Islands region is carried out intensively and the price of nutmeg farms received by farmers is higher, The competitive and comparative advantage of nutmeg farming in the Banda Islands region is higher than in the Ambon Island region. All these results suggest that in general nutmeg farming in the Banda Islands region is more competitive than in the Ambon Island region.
Simultaneous detection of the Ca and Ca+ layers by a dual-wavelength tunable lidar system
Authors: Wu Fuju , Zheng Haoran , Cheng Xuewu , Yang Yong , Li Faquan , Gong Shunsheng , Du Lifang , Wang Jihong , Yang Guotao 
Published: March 2020

A dual-wavelength tunable lidar system that simultaneously detects the Ca and

C
a

+

layers has been established in Yanqing Station (40.41°N, 116.01°E). The lidar system implements a pulsed Nd:YAG laser that simultaneously pumps two dye lasers, which reduces the hardware configuration of the lidar system. The two dye lasers use infrared laser dyes with high conversion efficiency suitable for long-term observation. The resonance wavelengths of Ca and

C
a

+

are generated by frequency doubling of the two infrared laser beams. We compared the dual-wavelength tunable lidar system to previous dye-based systems and performed experiments to determine resonance frequencies to within 0.4 pm and to test the dual optical fiber receiving system and found it does not cause cross talk. Three nights of preliminary simultaneous observations of Ca and

C
a

+

layers are reported; the diversity of these observations begs for more systematic observations and challenging interpretations in terms of Ca processes in the ionosphere and illustrates the effectiveness of this system for aeronomy and space physics studies.
A case of double standards? Audience attitudes to professional norms on local and English language radio news programmes in Ghana
Authors: Gadzekpo Audrey , Yeboah-Banin Abena Animwaa , Akrofi-Quarcoo Sarah 
Published: March 2020

AbstractThe proliferation of radio stations across Africa has engendered an increase in local language radio stations and fuelled culturally-rooted practices of news delivery considered by many media professionals as sub-standard. This article explores the reception practices of multi-lingual audiences in Ghana, focusing on their views on the different norms and approaches of local language and English language radio newscasts. Using data from a convenience sample of 1000 radio listeners in five Ghanaian cosmopolitan cities the study finds that audiences prefer more performative modes of news delivery on their local language stations. It was also evident that radio audiences are discerning and make distinctions between what is acceptable on local language versus English language radio. These results call for a reconsideration of western-influenced standards of news delivery and the development of professional standards more accommodating of the inflections of culture.
China colonizing Africa narrative on social media: An issue activation and response perspective
Authors: Matingwina Simon 
Published: March 2020

Abstract
The issue of ‘China colonizing Africa’ received significant attention in both traditional and social media in the periods before, during and after the Forum on China Africa Cooperation (FOCAC) 2018 meeting. This study traces these discourses on YouTube, which is one of the social media platforms widely used to raise awareness and also influence public opinion on various issues. Thematic and content analysis are used to identify the dominant themes discussed in the selected videos and also to identify the sentiments expressed by viewers in the comments posted. The issue activation and response model is used to create meaning from the data. The study finds that the themes and the sentiments reflect the dominance of pessimistic and optimistic perspectives on the Africa–China relationship. Furthermore, the study shows that the themes discussed have not offered new perspectives but instead the discussions have repackaged old narratives as part of agenda building efforts by the protagonists. The study, therefore argues that social media have become important platforms for activation of issues on the Africa–China relationship, hence the persistence of these old narratives is attributed to lack of effective responses to issues on social media by both African countries and Chinese officials.
Apical periodontitis in relation to radiographic quality of endodontic treatment in a selected adult Turkish population: A cross-sectional study
Authors: Sezgin Güzide Pelin , Sönmez Kaplan Sema , Kaplan Tuna 
Published: March 2020

Objective: The aim of this study was to examine the quality of root canal fillings and their relationship with apical periodontitis (AP) in a selected Turkish population. Material and Methods: The cases in this study was formed of patients attending routine dental treatment at the Faculty of Dentistry, University of Birun. 1024 patients were examined with panoramic radiographs and 1780 endodontically treated teeth with present periapical radiographs. Endodontic treatment quality was evaluated by obturation length, density, taper quality and iatrogenic errors. Presence of AP was analysed according to Ørstavik’s periapical index (PAI). The chi-square test was used for statistical analyses. Results: Statistically significant relationship was found between both the tooth type and location with obturation quality (p: 0.000; p < 0.05). Obturation quality of maxillary and mandibular molars are significantly less than the other tooth types in the same location. Apical periodontitis were noticed in 740 teeth (41.6%). Inadequate obturation quality was found to be significantly effective on the periapical status of tooth types both in maxilla and mandible (p < 0.05). Conclusion: The frequency of inadequate root canal obturations of endodontically treated teeth of the selected Turkish population was high, especially in molar teeth and women. Even though radiographic obturation quality is not the only success criteria in endodontic treatment, it is still one of the most important criteria regarding the positive correlation of “inadequate” obturations with AP.KEYWORDSPeriapical periodontitis; Radiography; Root canal obturation; Root canal theraphy.
Differential operators on almost-Hermitian manifolds and harmonic forms
Authors: Tardini Nicoletta , Tomassini Adriano 
Published: March 2020

AbstractWe consider several differential operators on compact almost-complex, almost-Hermitian and almost-Kähler manifolds. We discuss Hodge Theory for these operators and a possible cohomological interpretation. We compare the associated spaces of harmonic forms and cohomologies with the classical de Rham, Dolbeault, Bott-Chern and Aeppli cohomologies.
On the Convergence of the Elastic Flow in the Hyperbolic Plane
Authors: Müller Marius , Spener Adrian 
Published: March 2020

AbstractWe examine the L2-gradient flow of Euler’s elastic energy for closed curves in hyperbolic space and prove convergence to the global minimizer for initial curves with elastic energy bounded by 16. We show the sharpness of this bound by constructing a class of curves whose lengths blow up in infinite time. The convergence results follow from a constrained sharp Reilly-type inequality.