bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double Biologic Therapy for Refractory Stricturing Crohn’s Disease: A Successful Case of Deep Remission with Ustekinumab and Vedolizumab
Authors: Elmoursi Ahmed , Barrett Terrence A , Perry Courtney 
Published: May 2020

Abstract
Stricturing Crohn’s disease (CD) is a severe phenotype that presents unique challenges to therapeutic management. Emerging literature suggests that anti-TNF monoclonal antibody (mAb) therapies are inadequate for preventing progression to stricture. We hereby present a case of a patient with refractory CD who required multiple surgical resections despite several anti-TNF treatment regimens. Subsequent surgical complications were avoided after changing to combination vedolizumab and ustekinumab therapies every 4 weeks. This case argues for a tailored approach to CD therapy based on disease phenotype and demonstrates that combination therapy with ustekinumab and vedolizumab is a viable option for patients with stricturing disease.
Reversibility of Multimodal Shift: Zebrafish Shift to Olfactory Cues When the Visual Environment Changes
Authors: Suriyampola Piyumika S , Lopez Melissa , Ellsworth Brontë E , Martins Emília P 
Published: May 2020

Synopsis
Animals can shift their reliance on different sensory modalities in response to environmental conditions, and knowing the degree to which traits are reversible may help us to predict their chances of survival in a changing environment. Here, using adult zebrafish (Danio rerio), we found that 6 weeks in different light environments alone were sufficient to shift whether fish approached visual or chemical cues first, and that a subsequent reversal of lighting conditions also reversed their sensory preferences. In addition, we measured simple behavioral responses to sensory stimuli presented alone, and found that zebrafish housed in dim light for 6 weeks responded weakly to an optomotor assay, but strongly to an olfactory cue, whereas fish experiencing bright light for 6 weeks responded strongly to the visual optomotor stimulus and weakly in an olfactory assay. Visual and olfactory responses were equally reversible, and shifted to the opposite pattern when we reversed lighting conditions for 6 weeks. In contrast, we did not find a change in activity level, suggesting that changes in multiple sensory modalities can buffer animals from changes in more complex forms of behavior. This reversal of sensory response provides insight into how animals may use sensory shifts to keep up with environmental change.
Different aortic arch surgery methods for type A aortic dissection: clinical outcomes and follow-up results
Authors: Xue Yunxing , Pan Jun , Cao Hailong , Fan Fudong , Luo Xuan , Ge Min , Chen Yang , Wang Dongjin , Zhou Qing 
Published: May 2020

Abstract

OBJECTIVES
The aim of this study was to investigate the clinical outcomes and follow-up results among 5 main aortic arch surgery methods for type A aortic dissection in a single centre.

METHODS
From 2002 to 2018, 958 type A aortic dissection patients who received surgical repair were divided into 5 groups according to the arch surgery method: hemiarch replacement (n = 206), island arch replacement (n = 54), total arch replacement with frozen elephant trunk (n = 425), triple-branched stent (n = 39) and fenestrated stent (n = 234). The indications for the different arch methods were related to the patient’s preoperative status, the location and extent of the dissection and the surgical ability of the surgeons. A comparative study was performed to identify the differences in the perioperative data, and the Kaplan–Meier analysis was used to assess the long-term survival and reintervention rates. Thirty matched surviving patients that were included in each group completed Computed tomography angiography to determine long-term reshaping effect.

RESULTS
The 30-day mortality rate was 15.8%, and there was no difference among the 5 groups (P = 0.848). The follow-up survival rates were similar among the 5 groups (P = 0.130), and the same was true for patients without reintervention (P = 0.471). In the propensity matching study, patients with stents (frozen elephant trunk, triple-branched stent, fenestrated stent) had a slower aortic dilation rate and a higher ratio of thrombosis in the false lumen at the descending aortic and abdominal aortic levels than patients without stents.

CONCLUSIONS
No standard method is available for arch surgery, and indications and long-term effects should be identified with clinical data. In our experiences, simpler surgical procedures could reduce mortality in critically ill patients and stents in the distal aorta could improve long-term reshape effects.
On the complexity of an augmented Lagrangian method for nonconvex optimization
Authors: Grapiglia Geovani Nunes , Yuan Ya-xiang 
Published: May 2020

Abstract
In this paper we study the worst-case complexity of an inexact augmented Lagrangian method for nonconvex constrained problems. Assuming that the penalty parameters are bounded we prove a complexity bound of $\mathcal{O}(|\log (\epsilon )|)$ outer iterations for the referred algorithm to generate an $\epsilon$-approximate KKT point for $\epsilon \in (0,1)$. When the penalty parameters are unbounded we prove an outer iteration complexity bound of $\mathcal{O}(\epsilon ^{-2/(\alpha -1)} )$, where $\alpha&gt;1$ controls the rate of increase of the penalty parameters. For linearly constrained problems these bounds yield to evaluation complexity bounds of $\mathcal{O}(|\log (\epsilon )|^{2}\epsilon ^{-2})$ and $\mathcal{O}(\epsilon ^{- (\frac{2(2+\alpha )}{\alpha -1}+2 )})$, respectively, when appropriate first-order methods ($p=1$) are used to approximately solve the unconstrained subproblems at each iteration. In the case of problems having only linear equality constraints the latter bounds are improved to $\mathcal{O}(|\log (\epsilon )|^{2}\epsilon ^{-(p+1)/p})$ and $\mathcal{O}(\epsilon ^{-(\frac{4}{\alpha -1}+\frac{p+1}{p})})$, respectively, when appropriate $p$-order methods ($p\geq 2$) are used as inner solvers.
China, Japan, and the Governance of Space: prospects for competition and cooperation
Authors: Pekkanen Saadia M. 
Published: May 2020

AbstractChina and Japan are among the world’s top space powers, with significant technical competence in both conventional and ‘newspace’ capabilities. Since the early 1990s, each country has also taken a keen interest in shaping the governance of outer space activities. But they have done so in remarkably different ways, calling into question Asian states’ supposed preferences for soft and informal institutions. Japan has led the Asia-Pacific Regional Space Agency Forum, involving both state and nonstate participants, which is guided by a set of principles. China has opted for a high-profile formal intergovernmental design, the Asia-Pacific Space Cooperation Organization, with a Convention and all the trappings of a formal organizational structure. This article assesses the activities of China and Japan in the new space race, discusses how and why the design of their space governance differs, and reflects on prospects for competition and cooperation.
Effects of source and concentration of neutral detergent fiber from roughage in beef cattle diets on feed intake, ingestive behavior, and ruminal kinetics
Authors: Goulart Rodrigo S , Vieira Ricardo A M , Daniel Joao L P , Amaral Rafael C , Santos Vanessa P , Toledo Filho Sergio G , Cabezas-Garcia Edward H , Tedeschi Luis O , Nussio Luiz G 
Published: May 2020

AbstractThe objectives of this research were to evaluate the effects of source and concentration of α-amylase-treated neutral detergent fiber (aNDF) from roughage on feed intake, ingestive behavior, and ruminal kinetics in beef cattle receiving high-concentrate diets. Six ruminally cannulated Nellore steers (408 ± 12 kg of body weight) were randomly assigned to a 6 × 6 Latin square design with six diets: 10% aNDF from corn silage (10CS); 20% aNDF from corn silage (20CS); or four diets containing 10% aNDF from corn silage and 10% aNDF from one of the following sources: sugarcane (SC), sugarcane bagasse (SCB), soybean hulls (SH), or low oil cottonseed hulls (LOCH). The parameters of passage and degradation kinetics were estimated based on a two-compartmental model with gamma- and exponential-distributed residence times. The nonlinear models were fitted by nonlinear least squares, and a linear mixed-effects model was fitted to all variables measured from the Latin square design that were related to intake, digestibility, digestion kinetic parameters, and residence times. Mean particle size (MPS) between roughage sources (CS, SCB, and SC) and coproducts (SH and LOCH) was affected (P &lt; 0.05). Dry matter intake (DMI) was not affected (P &gt; 0.05) by 20CS, SC, SH, or LOCH. Steers fed 20CS or LOCH diets had 16% and 20% greater DMI, respectively, (P &lt; 0.05) than steers fed 10CS diet. Steers fed SCB consumed the least dry matter (DM). The SH and LOCH diets had lower MPS values (about 8.77 mm) in comparison to 20CS, SCB, and SC diets (about 13.08 mm) and, consequently, affected (P &lt; 0.05) rumen content, ruminal in situ disappearance, nutrient digestibility, and solid fractional passage rate. Chewing time was affected (P &lt; 0.05) by roughage sources and concentration. Lower values of distance travel inside the rumen (min/cm) were observed (P &lt; 0.05) for the SCB and SC diets in comparison with any other diet. Except for SCB, there was no difference (P &gt; 0.05) in rumen fill, among other treatments. Mean daily ruminal pH was not affected (P &gt; 0.05) by 20CS, SCB, SC, and LOCH diets, and it ranged from 6.1 to 6.23. Total short-chain fatty acids concentration was affected (P &lt; 0.05) by roughage source and concentration. Based on our results, we recommend that under Brazilian finishing diets, replacing roughage sources, except for SCB, based on aNDF concentration of the roughage in high-concentrate diets containing finely ground flint corn does not affect DMI.
The effect of reduced dietary glycine and serine and supplemental threonine on growth performance, protein deposition in carcass and viscera, and skin collagen abundance of nursery pigs fed low crude protein diets
Authors: Silva Kayla E , Huber Lee-Anne , Mansilla Wilfredo D , Shoveller Anna K , Htoo John K , Cant John P , de Lange Cornelis F M 
Published: May 2020

Abstract
Thirty five barrows (initial body weight [BW]: 15.1 ± 1.0 kg) were used to determine the effect of partially replacing Gly + Ser with Thr in reduced crude protein (CP) diets on growth performance, protein deposition in carcass and viscera, and skin collagen abundance during the late nursery phase to 25 kg BW. Pigs were individually fed one of five iso-nitrogenous diets (n = 7) for 21 d. The basal diet met estimated essential amino acids (AA) requirements by using all essential AA plus Gly and Ser in free form (CON; 12.1% CP; as-fed, analyzed contents). The remaining four diets were formulated by reducing total Gly and Ser concentrations to 60% or 20% of the CON diet. The N removed with Gly and Ser was replaced with either crystalline Thr or Glu. Total analyzed Thr made up either 1.59% (T1; 12.5% CP) or 2.34% (T2; 12.2% CP) of the Thr-supplemented diets, and total analyzed Glu made up either 3.47% (G1; 12.7% CP) or 4.64% (G2; 12.9% CP) of the Glu-supplemented diets. Pigs were slaughtered on day 21 to determine body composition and skin collagen abundance via bright field microscopy. Overall, average daily gain (ADG) and G:F and final carcass weights were greater for pigs fed diets supplemented with Glu (G1 + G2) vs. those fed diets supplemented with Thr (T1 + T2; P &lt; 0.05, P = 0.060, and P = 0.050 for ADG, G:F, and final carcass weight, respectively); intermediate values were observed for CON. Nitrogen retention in carcass plus viscera and the AA profile of deposited protein in the carcass were not influenced by dietary treatment. Pigs fed the T2 and G2 diets had greater retention of Thr (vs. CON and G2) and Glu (vs. CON and T2) in the viscera protein, respectively (P &lt; 0.05). The apparent utilization efficiency of standardized ileal digestible Thr for protein deposition in carcass plus viscera was less for pigs fed T2 (15.1%) vs. those fed CON (56.7%) or G2 (58.6% ± 2.9%) diets (P &lt; 0.001). Only pigs fed T1 had skin collagen abundance not different from CON; pigs fed G1, G2, and T2 had reduced skin collagen abundance compared with CON and T1 (P &lt; 0.01). Using Glu as an N source when Gly and Ser were reduced to 60% and 20% of CON in reduced CP diets maintained ADG for pigs between 15 and 25 kg BW, whereas supplying Thr as a N source reduced ADG and carcass weight. When dietary Gly and Ser were supplied at 60% of CON, only Thr supplementation rescued skin collagen abundance. Therefore, supplemental Thr at excess levels is not sufficient to replace N from Gly and Ser in reduced CP diets fed to late nursery pigs, despite supporting skin collagen abundance as a secondary indicator of Gly status.
Quality of Life in Adults With Lower Limb Burn Injury
Authors: Riaz Hafiz Muddassir , Mehmood Bhatti Zahid 
Published: May 2020

Abstract
Burn injury is an unpredictable incident that may result in long-term disability. Complications after burn injury are most common, for example, contracture, hypertrophic scar, or infection. A descriptive cross-sectional study was conducted at a burn unit in Pakistan, and data were collected by “World Health Organization Disability Assessment Schedule (WHODAS) v 2.0 Self-Administered” from 140 burn victims with at least 6 months old injury. Subjects with at least 10% TBSA of either lower limb were included while patients suffering from any congenital or neurological disease or with amputation were excluded. The analyses were done by statistic version 16. Participant’s mean age was 28.13 years and SD was ±7.87 years. Of the 140 patients, 96 (68.6%) were males and 44 (31.4%) were females. The cause of the burn injury was flame burn [72.9% (102)], chemical burn [5% (7)], scald burn [7.9% (11)], and electrical burn [14.3% (20)]. There were 74(52.9%) victims having burn injury at the right-hand side of the body and 47.1% (66) were with the left-hand side affected; 32.9% (46) were having burn injury at the hip joint, 37.9% (53) with the knee joint, 8.6% (12) ankle joint, and 20.7% (29) are having burn injury at whole limb. The mean disability score calculated by WHODAS v 2.0 self-administered was 13.96 with a SD of ±4.696. Burn injuries to the lower limb have a negative impact on all domains of quality of life of the victims. These individuals should be assessed at various times while developing a comprehensive rehabilitation treatment plan, especially focusing on the issues faced by such individuals to improve their quality of life.
Bioimpedance Spectroscopy Is a Valid and Reliable Measure of Edema Following Hand Burn Injury (Part 1—Method Validation)
Authors: Edwick Dale O , Hince Dana A , Rawlins Jeremy M , Wood Fiona M , Edgar Dale W 
Published: May 2020

AbstractThe assessment of swelling following burn injury is complicated by the presence of wounds and dressings and due to patients experiencing significant pain and impaired movement. There remains a lack of sensitive objective measures for edema in patients presenting with hand burn injury. Bioimpedance spectroscopy (BIS) is a measure of body composition that has been demonstrated by our group to be reliable for measuring whole body and limb edema during resuscitation and to be sensitive to edema changes within healing wounds. The aim of this study was to determine the reliability and validity of BIS as a measure of edema following hand burn injury specifically. One hundred patients presenting with burn injury including a portion of a hand were recruited to this trial. Repeated measures of the hand were recorded using a novel application of BIS and in parallel with water displacement volumetry (WDV). The results were analyzed using mixed-effects regressions. Paired repeated measures were obtained for 195 hands, using four electrode configurations. BIS demonstrated high reliability in measuring hand BIS—Intraclass Correlation Coefficient 0.995 to 0.999 (95% CI 0.992–1.000) and sensitivity—Minimum Detectable Difference 0.74 to 3.86 Ω (0.09–0.48 Ω/cm). A strong correlation was shown with WDV, Pearson’s r = −0.831 to −0.798 (P &lt; .001). BIS is a sensitive and reliable measure of edema following acute hand burn injury.
Safety of Early Postoperative Range of Motion in Burn Patients With Newly Placed Hand Autografts: A Pilot Study
Authors: Dewey William Scott , Cunningham Kyle B , Shingleton Sarah K , Pruskowski Kaitlin A , Welsh Ashley , Rizzo Julie A 
Published: May 2020

Abstract
Patients who suffer hand burns are at a high contracture risk, partly due to numerous cutaneous functional units, or contracture risk areas, located within the hand. Patients who undergo split-thickness skin grafting are often immobilized postoperatively for graft protection. Recent practice at our burn center includes an early range of motion (EROM) following hand grafting to limit unnecessary immobilization. The purpose of this study was to determine whether EROM is safe to perform after hand grafting and if there is any clinical benefit. This retrospective, matched case–control study of adults compared patients who received EROM to subjects who received the standard 3 to 5 days of postoperative immobilization. Patients were evaluated for graft loss and range of motion. Seventy-one patients were included in this study: 37 EROM patients and 34 matched controls. Six patients experienced minor graft loss, three of these were not attributable to EROM. All graft loss was less than 1 cm and none required additional surgery. Significantly more patients who received EROM achieved full-digital flexion by the first outpatient visit (25/27 = 92.6% vs 15/22 = 68.2%; P = .028). Performing EROM does not cause an increase in graft loss. All areas of graft loss from the EROM group healed without intervention. There appears to be a benefit to EROM since there was a significant improvement in the patients’ ability to make a full fist at initial outpatient follow-up. Additional prospective analysis is needed to examine the true clinical utility of EROM in the hand and other contracture-prone areas.
Adulticidal Activity of Melaleuca alternifolia (Myrtales: Myrtaceae) Essential Oil With High 1,8-Cineole Content Against Stable Flies (Diptera: Muscidae)
Authors: Dillmann Janaína Brand , Cossetin Luciana Filippin , de Giacometi Marjorie , Oliveira Dionatan , de Matos Antônio Francisco Igor Magalhães , Avrella Pamela Daniele , Garlet Quelen Iane , Heinzmann Berta Maria , Monteiro Silvia Gonzalez 
Published: May 2020

Abstract
The stable fly, Stomoxys calcitrans (Linnaeus 1758), is a hematophagous fly responsible for causing loss of performance in horses, causing losses in cattle productivity, and impacting the animals’ health through the spread of pathogenic microorganisms. The objective of this work was to investigate the insecticidal activity of essential oil obtained from Melaleuca alternifolia (Cheel), presenting high 1,8-cineole content, against S. calcitrans adults. Insecticidal activity was determined using surface application methods and exposure to oil impregnated paper. It was observed that treatments at 25 and 50 μg/cm2 (P &lt; 0.05) present fumigant activity through exposure to the impregnated paper, and in the first 15 min of exposure, the mortality rates obtained for these treatments were, respectively (96.6 ± 3.3% and 100%), equivalent to the positive control. Using the superficial application method, the only treatment concentration presenting adulticidal action was 5% (w/v) (P &lt; 0.05). Respective toxicities LC50 (%, w/v) and LC80 for the impregnated paper method were 1.06 ± 0.02 and 1.47 ± 0.17; for the superficial application method, they were 3.82 ± 0.65 and 5.53 ± 0.74. As demonstrated, M. alternifolia essential oil presents adulticidal potential against S. calcitrans.
When cancer encounters COVID-19 in China: what have we suffered, experienced and learned
Authors: Chen Haiyang , Wu Xuan , Wang Wei , Wang Qiming 
Published: May 2020

Abstract
The outbreak of the coronavirus disease (COVID-19) occurred in Wuhan, China, in December 2019. As of 21 March 2020, this epidemic has spread to 179 countries with more than 200 000 confirmed cases and 8578 deaths. The outbreak has put enormous pressure on the medical establishment and even led to exhaustion of medical resources in the most affected areas. Other medical work has been significantly affected in the context of COVID-19 epidemic. In order to reduce or avoid cross-infection with COVID-19, many hospitals have taken measures to limit the number of outpatient visits and inpatients. For example, emergency surgery can only be guaranteed, and most other surgeries can be postponed. Patients with cancer are one of the groups most affected by the epidemic because of their systematic immunosuppressive state and requirement of frequent admission to hospital. Consequently, specific adjustments for their treatment need to be made to cope with this situation. Therefore, it is of significance to summarize the relevant experience of China in the prevention and control of COVID-19 infection and treatment of patients with cancer during the epidemic.
Is mutation analysis of β-catenin useful for the diagnosis of desmoid-type fibromatosis? A systematic review
Authors: Sakai Tomohisa , Hamada Shunsuke , Koike Hiroshi , Shimizu Koki , Yoshida Masahiro , Nishida Yoshihiro 
Published: May 2020

AbstractBackgroundAn accurate diagnosis is crucial to determine the treatment modality for desmoid-type fibromatosis, although the histopathological diagnosis is occasionally difficult to make. Many desmoid-type fibromatosis have been reported to have hotspot mutation of β-catenin gene (CTNNB1). In the present study, we performed a systematic review to verify the usefulness of CTNNB1 mutation analysis in the diagnosis of desmoid-type fibromatosis.MethodsA literature search from January 1990 to August 2017 was conducted. Three reviewers independently assessed and screened the literature for eligibility and determined the final articles to be evaluated. Data regarding the sensitivity, specificity, accuracy and usefulness of CTNNB1 mutation analysis in the diagnosis of desmoid-type fibromatosis were recorded. We rated each report according to the Grading of Recommendations Development and Evaluation approach.ResultsThe search yielded 90 studies, seven of which were included after the first and second screenings. The positive rate of CTNNB1 mutation in desmoid-type fibromatosis was 86.8%, but the cohort of six of the seven reports was already diagnosed histopathologically as desmoid-type fibromatosis. Therefore, the usefulness of CTNNB1 mutation analysis in a cohort that is difficult to diagnose histopathologically is not clear in this review. Nevertheless, CTNNB1 mutation showed very high specificity in desmoid-type fibromatosis, indicating the usefulness of CTNNB1 mutation analysis in its diagnosis in combination with histological examination.ConclusionBecause the lack of data precludes any useful comparison with histological diagnosis, the evidence level is low. However, considering its specificity, CTNNB1 mutation analysis may be useful in cases in which the histopathological diagnosis is difficult.