bluuebunny/crossref_metadata_2025_split huggingface dataset:
4025 Fall Risk Screening and Referrals to Community-Based Programs among Physical Therapy Professionals
Authors: Vincenzo Jennifer L. , Shubert Tiffany , Brach Jennifer S. , Tripken Jennifer , Schrodt Lori , Sidelinker Jennifer C. , Hazan Patrice , Hergott Colleen , Shirley Kathleen , Rhorer Beth 
Published: July 2020

OBJECTIVES/GOALS:
To describe trends in fall risk screening and referrals to community-based programs among physical therapy professionals.To compare fall risk screening practices to clinical practice guidelines amongTo identify gaps in fall risk screening and referrals to community-based programs among physical therapy professionals.METHODS/STUDY POPULATION: A panel of experts between the American Physical Therapy Association (APTA) - Geriatrics, and the National Council on Aging (NCOA) developed a web-based survey to identify practices among physical therapy professionals (PTs) for fall risk screenings and community-based referrals for older adults. The web-based survey was disseminated to PTs via email, e-blasts, and social media. The survey focused on questions related to knowledge of fall risk screening tools, fall risk management for older adults, and knowledge of and referrals to community-based interventions. RESULTS/ANTICIPATED RESULTS: To date, 453 PTs representing 50 states completed the survey. The majority of PTs (50.9%) had over 20 years of experience in various settings. Eighty-three percent regularly screen older adults for fall risk. Approximately 40% conduct community-based screenings. The majority (81.3%) were somewhat to very familiar with the CDC-recommended STEADI (Stopping Elderly Accidents, Deaths, and Injuries) screening toolkit. Despite familiarity, only 32% responded to the question if they used STEADI for screening. Of those, 83.4% used the tool. The majority (73.4%) of PTs were aware that NCOA recommends evidence-based programs to address health needs of aging adults and 59.6% refer. PTs did not refer due to lack of knowledge that programs existed (21.3%) or lack of knowledge of availability (33.3%). DISCUSSION/SIGNIFICANCE OF IMPACT: Although PTs are have some familiarity with the STEADI for fall risk screening, the tool is not common in practice. PTs are lacking awareness of local evidence-based community programs to address health needs of aging adults. Educational efforts should target these knowledge gaps and provide additional resources to improve referrals.
Expert knowledge assessment of threats and conservation strategies for breeding Hen Harrier and Short-eared Owl across Europe
Authors: FERNÁNDEZ-BELLON DARÍO , LUSBY JOHN , BOS JULES , SCHAUB TONIO , MCCARTHY ALAN , CARAVAGGI ANTHONY , IRWIN SANDRA , O’HALLORAN JOHN 
Published: July 2020

SummaryHen Harrier Circus cyaneus and Short-eared Owl Asio flammeus are open-country birds of prey with overlapping distributions. Although both species face similar conservation threats across their ranges, work to date has largely been undertaken at a national scale with few attempts to collate and assess factors relevant to their conservation at an international scale. Here we use an expert knowledge approach to evaluate the impact of conservation threats and the effectiveness of conservation strategies for each species across Europe. We report results of responses to a questionnaire from 23 Hen Harrier experts from nine countries and 12 Short-eared Owl experts from six countries. The majority of responses for both species reported declines in breeding numbers. The perceived impact of threats was broadly similar for both species: ecological factors (predation, extreme weather and prey availability), changes in land use (habitat loss and agricultural intensification) and indirect persecution (accidental nest destruction) were considered to be the greatest threats to breeding Hen Harrier and Short-eared Owl. Short-eared Owl experts also highlighted lack of knowledge and difficulties associated with monitoring as a major conservation challenge. Despite broad-scale similarities, geographical variation was also apparent in the perceived importance of conservation threats, with some threats (such as direct persecution, large-scale afforestation or habitat degradation) requiring country-specific actions. Implementation of different conservation strategies also varied between countries, with the designation of protected areas reported as the most widespread conservation strategy adopted, followed by species and habitat management. However, protected areas (including species-specific protected areas) were perceived to be less effective than active management of species and habitats. These findings highlight the overlap between the conservation requirements of these two species, and the need for collaborative international research and conservation approaches that prioritise pro-active conservation strategies subject to continued assessment and with specific conservation goals.
Geoengineered Ocean Vertical Water Exchange Can Accelerate Global Deoxygenation
Authors: Feng Ellias Yuming , Su Bei , Oschlies Andreas 
Published: July 2020

AbstractOcean deoxygenation is a threat to marine ecosystems. We evaluated the potential of two ocean intervention technologies, that is, “artificial downwelling (AD)” and “artificial upwelling (AU),” for remedying the expansion of Oxygen Deficient Zones (ODZs). The model‐based assessment simulated AD and AU implementations for 80 years along the eastern Pacific ODZ. When AD was simulated by pumping surface seawater to the 178–457 m‐depth range of the ODZ, vertically integrated oxygen increased by up to 4.5% in the deployment region. Pumping water from 457 m depth to the surface (i.e., AU), where it can equilibrate with the atmosphere, increased the vertically integrated oxygen by 1.03%. However, both simulated AD and AU increased biological production via enhanced nutrient supply to the sea surface, resulting in enhanced export production and subsequent aerobic remineralization also outside of the actual implementation region, and an ultimate net decline of global oceanic oxygen.
The Sources of Uncertainty in the Projection of Global Land Monsoon Precipitation
Authors: Zhou Tianjun , Lu Jingwen , Zhang Wenxia , Chen Ziming 
Published: July 2020

AbstractPolicy makers need reliable future climate projection for adaptation purposes. A clear separation of sources of uncertainty also helps narrow the projection uncertainty. However, it remains unclear for monsoon precipitation projections. Here we quantified the contributions of internal variability, model uncertainty, and scenario uncertainty to the ensemble spread of global land monsoon precipitation projections using Coupled Model Intercomparison Project Phase 5 (CMIP5) models and single‐model initial‐condition large ensembles (SMILEs). For mean precipitation, model uncertainty (contributing ~90%) dominates the projection uncertainty, while the contribution of internal variability (scenario uncertainty) decreases (increases) with time. The source of uncertainty for extreme precipitation differs from that of mean precipitation mainly in long‐term projection, with the contribution of scenario uncertainty comparable to model uncertainty. Reducing model uncertainty can effectively narrow the monsoon precipitation projection. The internal variability estimates differ slightly among models and methods, the uncertainty partitioning is robust in middle‐long term.
Raindrop Signature from Microwave Radiometer Over Deserts
Authors: You Yalei , Joseph Munchak S. , Ferraro Ralph , Mohr Karen , Peters‐Lidard Christa , Prigent Catherine , Ringerud Sarah , Rudlosky Scott , Wang Heshun , Norouzi Hamidreza , Prakash Satya 
Published: July 2020

AbstractRainfall estimates from spaceborne microwave radiometers form the foundation of global precipitation data sets. Since the beginning of the satellite microwave rainfall estimation era in the 1980s, the primary signature leveraged over land for these estimates has been the brightness temperature (TB) depression due to ice particle scattering. Contrary to this practice, time series analyses based on observations from two spaceborne radars and two spaceborne radiometers reveal a TB increase at H19 due to raindrop emission as the primary cloud particle signature over desert terrain. Low surface emissivity supports the use of liquid raindrop emission as the primary signature over desert surfaces. In these regions, the surface rain rate better correlates with the liquid raindrop emission signal than with the scattering induced by ice further aloft, suggesting a new potential for improving rainfall estimation over deserts by exploiting the liquid raindrop emission signature.
Downward Continuation and Transformation of Total‐Field Magnetic Anomalies Into Magnetic Gradient Tensors Between Arbitrary Surfaces Using Multilayer Equivalent Sources
Authors: Zuo Boxin , Hu Xiangyun , Leão‐Santos Marcelo , Wang Lizhe , Cai Yi 
Published: July 2020

AbstractThe equivalent source method offers a potential means for continuing and manipulating magnetic data between arbitrary surfaces. However, it ultimately suffers from a limited continuation distance and significant errors, which restrict its applicability in practice. To address this problem, we reformulate the equivalent source method with a partial differential equation framework. A multilayer equivalent susceptibility method is innovatively derived based on this approach. The location of equivalent sources is designed for adaptive estimation through the inverse procedure. We introduce nonlinear optimization, regularization, and constraining technologies in inversion to improve the stability and accuracy of the solution. Synthetic, real airborne, and ground data are tested in experiments. The results show that the new method significantly improves the capability and accuracy of the downward continuation and transformation of irregularly located data between arbitrary undulating surfaces.
Can the Madden‐Julian Oscillation Affect the Antarctic Total Column Ozone?
Authors: Yang Chengyun , Smith Anne K. , Li Tao , Kinnison Douglas E. , Li Jianghanyang , Dou Xiankang 
Published: July 2020

AbstractThe effect of the Madden‐Julian Oscillation (MJO) on springtime Antarctic ozone variations is revealed for the first time from multi‐satellite reanalysis and model simulations. Twenty to 30 days after MJO Phase 8 (P8), Antarctic total column ozone (TCO) anomalies significantly decrease by up to −15 DU, associated with a wave‐1 response at around 60°S. After MJO P8, MJO‐related geopotential height anomalies in the southern hemispheric (SH) Indian Ocean emanate from subtropics to polar regions, leading to suppressed upward and poleward propagation of planetary waves (PWs) and weakened Brewer‐Dobson circulation in the SH stratosphere. This in turn results in less ozone transport from midlatitudes into the polar region and thus a negative polar TCO response. Dynamical transport plays a dominant role in modulating the Antarctic TCO after MJO P8. The magnitude of transient changes due to chemical processes is relatively weak than that caused by dynamical transport.
Current concepts in tumour-derived organoids
Authors: Porter Ross J. , Murray Graeme I. , McLean Mairi H. 
Published: July 2020

AbstractCancer comprises a collection of highly proliferative and heterogeneous cells growing within an adaptive and evolving tumour microenvironment. Cancer survival rates have significantly improved following decades of cancer research. However, many experimental and preclinical studies do not translate to the bedside, reflecting the challenges of modelling the complexities and multicellular basis of human disease. Organoids are novel, complex, three-dimensional ex vivo tissue cultures that are derived from embryonic stem cells, induced pluripotent stem cells or tissue-resident progenitor cells, and represent a near-physiological model for studying cancer. Organoids develop by self-organisation, and can accurately represent the diverse genetic, cellular and pathophysiological hallmarks of cancer. In addition, co-culture methods and the ability to genetically manipulate these organoids have widened their utility in cancer research. Organoids thus offer a new and exciting platform for studying cancer and directing personalised therapies. This review aims to highlight how organoids are shaping the future of cancer research.
Integrating single-cell RNA-sequencing and functional assays to decipher mammary cell states and lineage hierarchies
Authors: Regan Joseph L. , Smalley Matthew J. 
Published: July 2020

AbstractThe identification and molecular characterization of cellular hierarchies in complex tissues is key to understanding both normal cellular homeostasis and tumorigenesis. The mammary epithelium is a heterogeneous tissue consisting of two main cellular compartments, an outer basal layer containing myoepithelial cells and an inner luminal layer consisting of estrogen receptor-negative (ER−) ductal cells and secretory alveolar cells (in the fully functional differentiated tissue) and hormone-responsive estrogen receptor-positive (ER+) cells. Recent publications have used single-cell RNA-sequencing (scRNA-seq) analysis to decipher epithelial cell differentiation hierarchies in human and murine mammary glands, and reported the identification of new cell types and states based on the expression of the luminal progenitor cell marker KIT (c-Kit). These studies allow for comprehensive and unbiased analysis of the different cell types that constitute a heterogeneous tissue. Here we discuss scRNA-seq studies in the context of previous research in which mammary epithelial cell populations were molecularly and functionally characterized, and identified c-Kit+ progenitors and cell states analogous to those reported in the recent scRNA-seq studies.
Spatiotemporal DNA methylome dynamics of the developing mouse fetus
Authors: He Yupeng , Hariharan Manoj , Gorkin David U. , Dickel Diane E. , Luo Chongyuan , Castanon Rosa G. , Nery Joseph R. , Lee Ah Young , Zhao Yuan , Huang Hui , Williams Brian A. , Trout Diane , Amrhein Henry , Fang Rongxin , Chen Huaming , Li Bin , Visel Axel , Pennacchio Len A. , Ren Bing , Ecker Joseph R. 
Published: July 2020

AbstractCytosine DNA methylation is essential for mammalian development but understanding of its spatiotemporal distribution in the developing embryo remains limited1,2. Here, as part of the mouse Encyclopedia of DNA Elements (ENCODE) project, we profiled 168 methylomes from 12 mouse tissues or organs at 9 developmental stages from embryogenesis to adulthood. We identified 1,808,810 genomic regions that showed variations in CG methylation by comparing the methylomes of different tissues or organs from different developmental stages. These DNA elements predominantly lose CG methylation during fetal development, whereas the trend is reversed after birth. During late stages of fetal development, non-CG methylation accumulated within the bodies of key developmental transcription factor genes, coinciding with their transcriptional repression. Integration of genome-wide DNA methylation, histone modification and chromatin accessibility data enabled us to predict 461,141 putative developmental tissue-specific enhancers, the human orthologues of which were enriched for disease-associated genetic variants. These spatiotemporal epigenome maps provide a resource for studies of gene regulation during tissue or organ progression, and a starting point for investigating regulatory elements that are involved in human developmental disorders.
First evidence of microbial wood degradation in the coastal waters of the Antarctic
Authors: Björdal Charlotte G. , Dayton Paul K. 
Published: July 2020

AbstractWood submerged in saline and oxygenated marine waters worldwide is efficiently degraded by crustaceans and molluscs. Nevertheless, in the cold coastal waters of the Antarctic, these degraders seem to be absent and no evidence of other wood-degrading organisms has been reported so far. Here we examine long-term exposed anthropogenic wood material (Douglas Fir) collected at the seafloor close to McMurdo station, Antarctica. We used light and scanning electron microscopy and demonstrate that two types of specialized lignocellulolytic microbes—soft rot fungi and tunnelling bacteria—are active and degrade wood in this extreme environment. Fungal decay dominates and hyphae penetrate the outer 2–4 mm of the wood surface. Decay rates observed are about two orders of magnitude lower than normal. The fungi and bacteria, as well as their respective cavities and tunnels, are slightly smaller than normal, which might represent an adaptation to the extreme cold environment. Our results establish that there is ongoing wood degradation also in the Antarctic, albeit at a vastly reduced rate compared to warmer environments. Historical shipwrecks resting on the seafloor are most likely still in good condition, although surface details such as wood carvings, tool marks, and paint slowly disintegrate due to microbial decay.
Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis
Authors: Shariati Aref , Dadashi Masoud , Moghadam Majid Taati , van Belkum Alex , Yaslianifard Somayeh , Darban-Sarokhalil Davood 
Published: July 2020

AbstractVancomycin-resistantStaphylococcus aureus(VRSA), Vancomycin-intermediateS. aureus(VISA) and heterogeneous VISA (hVISA) are subject to vancomycin treatment failure. The aim of the present study was to determine their precise prevalence and investigate prevalence variability depending on different years and locations. Several international databases including Medline (PubMed), Embase and Web of Sciences were searched (data from 1997 to 2019) to identify studies that addressed the prevalence of VRSA, VISA and hVISA among human clinical isolates around the world. Subgroup analyses and meta-regression were conducted to indicate potential source of variation. Publication bias was assessed using Egger’s test. Statistical analyses were conducted using STATA software (version 14.0). Data analysis showed that VRSA, VISA and hVISA isolates were reported in 23, 50 and 82 studies, with an overall prevalence of 1.5% among 5855S. aureusisolates, 1.7% among 22,277 strains and 4.6% among 47,721 strains, respectively. The overall prevalence of VRSA, VISA, and hVISA before 2010 was 1.2%, 1.2%, and 4%, respectively, while their prevalence after this year has reached 2.4%, 4.3%, and 5.3%. The results of this study showed that the frequency of VRSA, VISA and hVISA after 2010 represent a 2.0, 3.6 and 1.3-fold increase over prior years. In a subgroup analysis of different strain origins, the highest frequency of VRSA (3.6%) and hVISA (5.2%) was encountered in the USA while VISA (2.1%) was more prevalent in Asia. Meta-regression analysis showed significant increasing of VISA prevalence in recent years (pvalue ≤ 0.05). Based on the results of case reports (which were not included in the calculations mentioned above), the numbers of VRSA, VISA and hVISA isolates were 12, 24 and 14, respectively, among different continents. Since the prevalence of VRSA, VISA and hVISA has been increasing in recent years (especially in the Asian and American continents), rigorous monitoring of vancomycin treatment, it’s the therapeutic response and the definition of appropriate control guidelines depending on geographical regions is highly recommended and essential to prevent the further spread of vancomycin-resistantS. aureus.
Long-term sustainability of biogas bubbles in sand
Authors: Hu Xiaoying , Li Dandan , Peng Erxing , Hou Zheng , Sheng Yu , Chou Yaling 
Published: July 2020

AbstractDesaturation is a new method to mitigate liquefaction of sand. It aims to prevent liquefaction by generating gas/air in the pores of fully saturated sands, and biogas is one of the most suitable gas. In order to evaluate the long-term sustainability of biogas bubbles, a series sustainability test on biogas bubbles in pores of sand was conducted with a one-dimensional device under hydrostatic condition, hydraulic gradient flow condition and horizontal excitation condition. The variation trend of the retention of biogas bubbles in the pores of soil under the aforementioned conditions was analyzed. Test results indicated that after 72 weeks of monitoring sand samples, biogas bubbles existed stably in the pores of soil under hydrostatic conditions. In hydraulic gradient flow, the stability under upward seepage flow showed a similar trend to that of downward seepage flow. When the hydraulic gradient was constant, the degree of saturation increased in a certain period and finally remained constant. When the hydraulic gradient increased by 0.1, 0.2, 0.3, 0.4, and 0.5, the degrees of saturation increase were 0.8%, 11.5%, 0.5%, 0.1%, and 0%, respectively. After 41,200 cycles with different accelerations, the degree of saturation of the sample increased slightly, and the biogas bubbles basically remained stable.
Action sound–shape congruencies explain sound symbolism
Authors: Margiotoudi Konstantina , Pulvermüller Friedemann 
Published: July 2020

AbstractSound symbolism, the surprising semantic relationship between meaningless pseudowords (e.g., ‘maluma’, ‘takete’) and abstract (round vs. sharp) shapes, is a hitherto unexplained human-specific knowledge domain. Here we explore whether abstract sound symbolic links can be explained by those between the sounds and shapes of bodily actions. To this end, we asked human subjects to match pseudowords with abstract shapes and, in a different experimental block, the sounds of actions with the shapes of the trajectories of the actions causing these same sounds. Crucially, both conditions were also crossed. Our findings reveal concordant matching in the sound symbolic and action domains, and, importantly, significant correlations between them. We conclude that the sound symbolic knowledge interlinking speech sounds and abstract shapes is explained by audiovisual information immanent to action experience along with acoustic similarities between speech and action sounds. These results demonstrate a fundamental role of action knowledge for abstract sound symbolism, which may have been key to human symbol-manipulation ability.
Continuous scanning for Bragg coherent X-ray imaging
Authors: Li Ni , Dupraz Maxime , Wu Longfei , Leake Steven J. , Resta Andrea , Carnis Jérôme , Labat Stéphane , Almog Ehud , Rabkin Eugen , Favre-Nicolin Vincent , Picca Frédéric-Emmanuel , Berenguer Felisa , van de Poll Rim , Hofmann Jan P. , Vlad Alina , Thomas Olivier , Garreau Yves , Coati Alessandro , Richard Marie-Ingrid 
Published: July 2020

AbstractWe explore the use of continuous scanning during data acquisition for Bragg coherent diffraction imaging, i.e., where the sample is in continuous motion. The fidelity of continuous scanning Bragg coherent diffraction imaging is demonstrated on a single Pt nanoparticle in a flow reactor at $$400\,^\circ \hbox {C}$$

400

∘

C

in an Ar-based gas flowed at 50 ml/min. We show a reduction of 30% in total scan time compared to conventional step-by-step scanning. The reconstructed Bragg electron density, phase, displacement and strain fields are in excellent agreement with the results obtained from conventional step-by-step scanning. Continuous scanning will allow to minimise sample instability under the beam and will become increasingly important at diffraction-limited storage ring light sources.