bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laryngeal tuberculosis mimicking malignancy: A case report
Authors: Eltilib Mohamed , Boyd William , Saramago Israel , Askin Frederic , Zamora Carlos 
Published: April 2020

AbstractLaryngeal involvement in tuberculosis is rare and may mimic malignancy. We report the case of a 26‐year‐old female who presented with sore throat for several months. CT revealed an infiltrative laryngeal mass and upper lobe pulmonary opacities. Laryngoscopic biopsy confirmed necrotizing granulomatous inflammation with positive culture for Mycobacterium tuberculosis.
Techno‐Economic Analysis for Production of L‐Arabitol from L‐Arabinose
Authors: Murzin Dmitry Yu. , Daigue Emilien , Slotte Robert , Sladkovskiy Dmitry A. , Salmi Tapio 
Published: April 2020

AbstractThe process design for synthesis of arabitol by hydrogenation of arabinose on a supported ruthenium catalyst is described. Aspen HYSYS software was used to design an arabitol production plant for subsequent generation of hydrogen through aqueous phase reforming (APR). The process design included hydrogen recycling requiring a flash drum and recompression. The total costs of arabitol were estimated to be substantially dependent on the feedstock costs and are closely related to arabinose feed cost. Feasible production of hydrogen using APR requires efficient extraction of hemicellulose from lignocellulosic biomass and subsequent hydrolysis.
Pembrolizumab for the treatment of programmed death–ligand 1‒positive advanced carcinoid or pancreatic neuroendocrine tumors: Results from the KEYNOTE‐028 study
Authors: Mehnert Janice M. , Bergsland Emily , O’Neil Bert H. , Santoro Armando , Schellens Jan H. M. , Cohen Roger B. , Doi Toshihiko , Ott Patrick A. , Pishvaian Michael J. , Puzanov Igor , Aung Kyaw L. , Hsu Chiun , Le Tourneau Christophe , Hollebecque Antoine , Élez Elena , Tamura Kenji , Gould Marlena , Yang Ping , Stein Karen , Piha‐Paul Sarina A. 
Published: April 2020

BackgroundDespite a protracted disease course and multiple available therapies, patients with well‐differentiated neuroendocrine tumors (NETs) inevitably experience disease progression. Programmed death–ligand 1 (PD‐L1) has been associated with NET progression and prognosis. The multicohort, phase 1 KEYNOTE‐028 study (ClinicalTrials.gov identifier NCT02054806) evaluated the activity and safety of the anti–programmed cell death protein 1 immunotherapy pembrolizumab in patients with well‐differentiated or moderately‐differentiated NETs.MethodsPatients with PD‐L1–positive, locally advanced or metastatic carcinoid or well–differentiated or moderately‐differentiated pancreatic NETs (pNETs) were enrolled into separate cohorts and received pembrolizumab at a dose of 10 mg/kg every 2 weeks for up to 2 years. The objective response rate was the primary endpoint (as per Response Evaluation Criteria in Solid Tumors version 1.1, by investigator review). Safety was a secondary endpoint.ResultsOf 170 and 106 patients, respectively, who had evaluable samples among those screened for the carcinoid and pNET cohorts, 21% and 25%, respectively, had PD‐L1–positive tumors; of these, 25 and 16 patients, respectively, were eligible and treated. The median follow‐up was 20 months (range, 2‐35 months) and 21 months (range, 5‐32 months), respectively. The objective response rate was 12.0% (95% CI, 2.5%‐31.2%) and 6.3% (95% CI, 0.2%‐30.2%), respectively; 3 partial responses occurred among the carcinoid cohort and 1 among the pNET cohort. The median duration of response in the carcinoid cohort was 9.2 months (range, 6.9‐11.1 months), and was not reached in the pNET cohort. No complete responses occurred. Treatment‐related adverse events occurred in 68% and 69% of patients, respectively, most often diarrhea (7 patients in the carcinoid cohort and 4 patients in the pNET cohort) and fatigue (6 patients in each cohort). Hypothyroidism was the most common immune‐mediated adverse event (5 patients in the carcinoid cohort and 2 patients in the pNET cohort).ConclusionsPembrolizumab demonstrated antitumor activity in a subset of patients with NETs and was well‐tolerated.
Identification of circulating tumor cells using 4‐color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low‐dose computed tomography–detected lung nodules
Authors: Katz Ruth L. , Zaidi Tanweer M. , Pujara Deep , Shanbhag Namita D. , Truong Duy , Patil Shekhar , Mehran Reza J. , El‐Zein Randa A. , Shete Sanjay S. , Kuban Joshua D. 
Published: April 2020

BackgroundApproximately one third of needle biopsies that are performed to rule out malignancy of indeterminate pulmonary nodules detected radiologically during lung cancer screening are negative, thus exposing cancer‐free patients to risks of pneumothorax, bleeding, and infection. A noninvasive confirmatory tool (eg, liquid biopsy) is urgently needed in the lung cancer diagnosis setting to stratify patients who should receive biopsy versus those who should be monitored.MethodsA novel antigen‐independent, 4‐color fluorescence in situ hybridization (FISH)‐based method was developed to detect circulating tumor cells (CTCs) with abnormalities in gene copy numbers in mononuclear cell–enriched peripheral blood samples from patients with (n = 107) and without (n = 100) lung cancer.ResultsIdentification of CTCs using FISH probes at 10q22.3/CEP10 and 3p22.1/3q29 detected lung cancer cases with 94.2% accuracy, 89% sensitivity, and 100% specificity compared with biopsy.ConclusionThe high accuracy of this liquid biopsy method suggests that it may be used as a noninvasive decision tool to reduce the frequency of unnecessary needle biopsy in patients with benign pulmonary lesions.
The impact of color preference on adolescent children's choice of furniture
Authors: Jiang Liling , Cheung Vien , Westland Stephen , Rhodes Peter A. , Shen Liming , Xu Lei 
Published: April 2020

AbstractIt is widely believed that children will choose furniture that has the same color as their preferred color. Furthermore, for different categories of furniture, the color they preferred for furniture is consistent. A study of 508 adolescent Chinese children between the ages of 12 and 16 has been carried out to explore whether color preference influences their choice of furniture when they are provided with various color options (16 chromatic and five achromatic colors). This work tested six items of furniture in two functional spaces (study and bedroom space). Findings indicate that adolescent children's color preferences did indeed affect their furniture choice, but the extent varies with the categories of furniture. Furthermore, this study reveals that children's preference for furniture in different functional spaces is slightly different. Some effects of gender and age were also explored. This work discusses the implications of adolescent color preference and color choice for children's furniture color design.
Production of F(ab′)2 from Monoclonal and Polyclonal Antibodies
Authors: Rosenstein Shai , Vaisman‐Mentesh Anna , Levy Limor , Kigel Aya , Dror Yael , Wine Yariv 
Published: April 2020

AbstractAntibodies are widely used in therapeutic, diagnostic, and research applications, and antibody derivatives such as F(ab′)2 fragments are used when only a particular antibody region is required. F(ab′)2 can be produced through antibody engineering, but some applications require F(ab′)2 produced from an original formulated antibody or directly from a polyclonal antibody pool. The cysteine protease immunoglobulin‐degrading enzyme (IdeS) from Streptococcus pyogenes digests immunoglobulin G (IgG) specifically and efficiently to produce F(ab′)2. Here we detail the production and purification of recombinant IdeS; its utilization to digest monoclonal or polyclonal antibodies to F(ab′)2 fragments; and F(ab′)2 purification through consecutive affinity chromatography steps. The resultant F(ab′)2 exhibit high purity, retain antigen‐binding functionality, and are readily utilizable in various downstream applications. © 2020 by John Wiley & Sons, Inc.Basic Protocol: Production and purification of F(ab′)2 fragments from monoclonal and polyclonal antibodies using IdeSAlternate Protocol: Purification of polyclonal antigen–specific F(ab′)2 fragments from human serum or secretionsSupport Protocol: Production and purification of IdeS
Neuronavigation‐Guided rTMS for the Treatment of Depressive Patients With Suicidal Ideation: A Double‐Blind, Randomized, Sham‐Controlled Trial
Authors: Pan Fen , Shen Zhe , Jiao JianPing , Chen Jinkai , Li Shangda , Lu Jing , Duan Jinfeng , Wei Ning , Shang Desheng , Hu Shaohua , Xu Yi , Huang Manli 
Published: April 2020

During the last decade, the problem of suicide has become more serious in individuals with depression. Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). This study aims to investigate the efficacy of magnetic resonance imaging (MRI)‐based neuronavigation‐guided daily high‐dose rTMS for rapidly improving suicidal ideation in treatment‐naive patients with MDD. In the present 1‐week double‐blind study, 42 treatment‐naive patients with MDD with suicidal ideation were randomly assigned to the treatment of escitalopram oxalate tablets (10 mg/d) in combination with either active (n = 21) or sham (n = 21) rTMS. The TMS coil was positioned over a specified target location (−44, 40, and 29) in left dorsolateral prefrontal cortex based on MRI data. The severity of suicidal ideation was measured by the Beck Scale for Suicide Ideation (BSI). The 24‐item Hamilton Depression Rating Scale (HAMD‐24) and Montgomery–Åsberg Depression Rating Scale (MADRS) were utilized to assess the severity of depression. The Wisconsin Card Sorting Test, Continuous Performance Test, and Stroop Color–Word Test were adopted to assess executive function. In contrast to the sham group, the active rTMS group showed a significantly greater BSI score reduction at the third day and the seventh day (P < 0.001). Moreover, the active rTMS group showed a significantly greater HAMD (P < 0.001) and MADRS (P < 0.001) score reduction at the seventh day in comparison to the sham group. The present findings suggested that the neuronavigation‐guided high‐dose rTMS may be a novel method to rapidly reduce suicidal ideation and mitigate depressive symptoms.
Coding structure of JMVDC along saliency mapping: a prespective compression technique
Authors: Manasa Veena T. , Satya Narayana D. , Giri Prasad M. N. 
Published: April 2020

SummarySummarizing of multi‐see video and penetrating information depicts an augmentation of the high‐performance video coding (HPVC) criterion. Multi‐see recordings taken by numerous cameras of the same scene from various positions and edges progress towards becoming feasible since little estimated and less value cameras are accessible. Multi‐see video enables the customers to unreservedly change their viewpoints whenever they need to see the scene from any position. For profundity coding, new intracoding modes, an altered movement pay, and movement vector coding and also the idea of movement parameter legacy are a piece of the HPVC expansion. A novel encoder control utilizes see blend improvement, which ensures that amazing middle of the road perspectives can be produced in view of the decoded information. The bit stream arrange bolsters the extraction of halfway piece streams, with the goal that traditional latest video standards like 2D, stereo, multi‐see in addition to profundity organization can be de‐transmit from a solitary piece stream. We proposed a novel saliency detection technique for stereoscopic pictures, which depends on local‐global differentiation highlights, trailed by encompassing district improvement and stereo focus earlier upgrade and furthermore we have proposed an algorithm that effectively chooses a near‐optimalinterview PS and related texture and profundity QPs, at GOP level, when the MVD information organize is utilized for IMVS frameworks. Objective and subjective outcomes are introduced, exhibiting that the proposed approach gives half piece rate investment funds in correlation with JMVDC simulcast and 22% in examination with a direct multi‐see expansion of JMVDC without the recently created coding instruments.
Studies on reproductive strategies of Vitex negundo L. var. heterophylla (Franch.) Rehder (Lamiaceae) based on morphological characteristics and SSR markers
Authors: Sun Xiaohan , Wang Feng , Cui Rong , Liu Xiao , Li Xiangxiang , Dong Jibin , Sun Lu , Qin Siqi , Wang Renqing , Zheng Peiming , Wang Hui 
Published: April 2020

AbstractVitex negundo L. var. heterophylla (Franch.) Rehder (Lamiaceae) is an important tree species for soil and water conservation, yet the reproductive ecology of this species remains to be elucidated. To investigate the reproductive traits of V. negundo var. heterophylla, the phenology, morphological characteristics (a suite of characters was assessed: floral morphology, nectar production, pollen viability, and stigma receptivity) and mating system of this species were systematically revealed for the first time in this study. Phenological observations, morphological measurements, and nectar production analysis were conducted during anthesis. Pollen viability and stigma receptivity at different flowering stages were measured by biochemical methods. Finally, genetic analysis based on SSR markers was used to reveal the mating system; outcrossing index and pollen‐ovule ratio were also calculated to help analysis. V. negundo var. heterophylla showed several obvious characteristics of outcrossing, such as abundant and attractive flowers, secreting nectar, and emitting scent. In addition, mechanisms such as homogamy and a short anther‐stigma distance that can promote self‐fertilization were also identified in this species. The coexistence of selfing and outcrossing characteristics demonstrates a predominantly outcrossed mixed mating system (outcrossing rate, t = 95%). The scientific information provided by this study may contribute to conservation of V. negundo var. heterophylla from a reproductive perspective.
Interspecific and interpopulation variation in individual diet specialization: Do environmental factors have a role?
Authors: Lunghi Enrico , Manenti Raoul , Cianferoni Fabio , Ceccolini Filippo , Veith Michael , Corti Claudia , Ficetola Gentile Francesco , Mancinelli, Giorgio 
Published: April 2020

AbstractIndividual diet specialization (IS) has important community‐ and population‐level implications and its ecological drivers are actively investigated. Here, to test the hypothesis that local environmental conditions may influence IS in wild populations, we analyzed the stomach contents of 395 individuals from eight populations of five allopatric species of European cave salamanders (genusHydromantes). We assessed whether their degree of individual diet specialization (1) scaled positively with the respective niche widths, in agreement with Van Valen’s niche variation hypothesis (NVH), and (2) could be predicted by satellite‐derived climatic and vegetation characteristics of the sites where the populations live. Consistent with the NVH, the degree of individual diet specialization increased with the populations’ total niche width. Furthermore, two variables describing local nonarboreal vegetation cover and habitat heterogeneity successfully predicted the variation in individual specialization across the eight populations. Climatic factors had a generally low predictive power, with individual specialization in low‐ and high‐elevation populations showing contrasting patterns of co‐variation with air temperature in the warmest quarter of the year. However, independently from elevation, specialization peaked under conditions of high nonarboreal vegetation cover and high precipitation regimes. We discussed the results against two mutually nonexclusive scenarios hypothesizing different mechanisms linking environmental factors to salamanders’ trophic strategy at an individual and population level. We concluded that satellite‐derived climatic and vegetation variables to date generally adopted to model Grinnellian niches might also be useful in predicting spatial variations in dietary habits of populations, that is, their Eltonian niches.
Usefulness of a personalized algorithm‐based discharge checklist in patients hospitalized for acute heart failure
Authors: Allain Florent , Loizeau Virginie , Chaufourier Laure , Hallouche Maya , Herrou Laurence , Hodzic Amir , Blanchart Katrien , Belin Annette , Manrique Alain , Milliez Paul , Sabatier Rémi , Legallois Damien 
Published: April 2020

AbstractAimsThe aim of this study is to evaluate the usefulness of a personalized discharge checklist (PCL) based on simple baseline characteristics on mortality, readmission for heart failure (HF), and quality of care in patients hospitalized for acute HF.Methods and resultsWe designed an algorithm to generate PCL, based on 2016 HF European Society of Cardiology Guidelines and the screening of common comorbidities in elderly HF patients. We prospectively included 139 patients hospitalized for HF from May 2018 to October 2018. A PCL was fulfilled for each patient at admission and 24 to 48 hours before the planned discharge. A control cohort of 182 consecutive patients was retrospectively included from May 2017 to October 2017. The primary composite endpoint was mortality or readmission for HF at 6 months. The secondary endpoints were mortality, readmission for HF, and quality of care (evidence‐based medications, management of HF comorbidities, and planned care plan). There was no difference among baseline characteristics between PCL and control cohorts; mean age was 78.1 ± 12.2 vs. 79.0 ± 12.5 years old (P = 0.46) and 61 patients (43.9%) vs. 63 (34.6%) had HF with left ventricular ejection fraction (LVEF) <40% (P = 0.24). During the 6 month follow‐up period, 59 patients (42.4%) reached the primary endpoint in the PCL cohort vs. 92 patients (50.5%) in the control cohort [hazard ratio (HR): 0.79, 95% confidence interval (CI) (0.57–1.09), P = 0.15]. Subgroup analysis including only patients with either altered (<40%) or mid‐range or preserved (≥40%) LVEF showed no significant difference among groups. There was a non‐significant trend toward a reduction in HF readmission rate in the PCL group [38 patients (27.3%) vs. 64 patients (35.2%), HR: 0.73, 95%CI (0.49–1.09), P = 0.13]. There was no difference regarding survival or the use of evidence‐based medications. A higher proportion of patients were screened and treated for iron and vitamin D deficiencies (53.2% vs. 35.7%, P < 0.01 and 73.4% vs. 29.7%, P < 0.01, respectively), as well as malnutrition supplemented in the PCL group. There was a higher referral to HF follow‐up programme in the PCL group but not to telemedicine or cardiac rehabilitation programs.ConclusionsIn this preliminary study, the use of a PCL did not improve outcomes at 6 months in patients hospitalized for acute HF. There was a non‐significant trend towards a reduction in HF readmission rate in the PCL group. In addition, the management of HF comorbidities was significantly improved by PCL with a better referral to follow‐up programme. A multicentre study is warranted to assess the usefulness of a simple costless personalized checklist in a large HF patients' population.
Modification of clayware ceramic membrane for enhancing the performance of microbial fuel cell
Authors: Suransh Jain , Tiwari Alok Kumar , Mungray Arvind Kumar 
Published: April 2020

AbstractThe aim of this study was to develop an economically viable clayware ceramic membrane that exhibits proton mass transfer comparable to the commercially available membrane (Nafion 117) for microbial fuel cell (MFC). The clayware ceramic membrane made from red soil was modified using cation exchangers like montmorillonite (MMT) and vermiculite (VC), and by spray coating of MMT composite with Nafion solution. Nafion‐117 (a commercial membrane) and membrane prepared using only red soil were used as a standard and control, respectively. Other membranes include 20% blend of MMT with red soil (SM); 20% VC with red soil (SV); 10% blend of each MMT and VC with red soil (SMV); and SM membrane spray‐coated with Nafion solution (SMN). The addition of cation exchangers enhances the performance of the clayware ceramic membranes as compared to the control, and coating of Nafion solution on SMN leads it to perform even better. Average open circuit voltage and average operating voltage for the SMN membranes were 670 ± 17.63 mV and 82 ± 5.69 mV, respectively, which are the best among all the fabricated membranes. The power density of the SMN membrane was 84.3 mW/m3 which is five times that of the control. The study demonstrates that SMN membrane can be used as an alternate for more costly polymeric membranes in MFC.
Energetic and economic analysis of a new integrated collector storage with honeycomb transparent insulation (ICSHTI)
Authors: Messaouda Anis , Hamdi Mohamed , Hazami Majdi , Guizani Amen Allah 
Published: April 2020

AbstractThis paper deals with both energetic and economic studies of a new integrated collector storage with honeycomb transparent insulation (ICSHTI) which was conceived, developed, and tested in the Research and Technology Centre of Energy (CRTEn), Tunisia. Experimental and numerical studies were performed in order to evaluate the thermal and the economic performances of the new solar collector configuration. Investigations are based on the daily efficiency, the heat loss coefficient and the long‐term performances. The results showed that the ICSHTI presents a mean daily efficiency around 51.60% and a heat loss coefficient equal to 5.51 W/m2K. Results also showed that the energy loaded from the ICSHTI is about 4,669 MJ which represents about 57% of the total domestic hot water (DHW) needs by considering only solar energy. By considering different scenarios of climatic conditions, TRNSYS and SOLO investigations showed that the average solar fraction is about 67 and 28% in hot and cold regions, respectively. To evaluate the feasibility of integrating the ICSHTI in local market, a comparison against the most commercialized DHW systems namely the flat‐plate solar collector (FPC) was conducted. The results showed that the FPC is more economical than the ICSHTI with a yearly economy YOER and a payback period PT equal to 120.2 US$/year and 12 years for the FPC and 102.3 US$/year and 14.3 years for the ICSHTI when we considered the PT based on electric water heater. However, when we considered a PT based on gas water heater, the ICSHTI system becomes more economical than the FPCDHW with a PT equal to 18.5 years and 20.5 years, for the two systems, respectively.
Theoretical study on stability of mine ventilation network based on sensitivity analysis
Authors: Jia Jinzhang , Jia Peng , Li Zhuang 
Published: April 2020

AbstractA mine ventilation system is a large and complex system. Its stability is affected by many factors, and wind resistance change is one of the common influencing factors. In order to study the influence of branch wind resistance changes on the branch air volume and the stability of the ventilation system, this paper introduced the concept of sensitivity, constructing a mathematical model of the influence of branch wind resistance changes on air volume. Based on the model, the sensitivity of each branch can be calculated, the sensitivity matrix can be constructed, and the influence of the branch wind resistance change on the air volume change can be quantitatively expressed. The sensitivity matrix can be used to analyze the stability of the mine ventilation system and can be used as an indicator of the optimization and comparison of the ventilation system. The branch with the most influence and the most affected degree in the ventilation system can be obtained, so the sensitivity matrix can accurately determine the best branches to raise resistance (or reduce resistance). This study can guide the design and optimization of mine ventilation systems.