bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Situation of Surgical Treatment for Rib Fractures in China: Questionnaires from Multi-hospital
Authors: Zhao Weigang , He Weiwei , Zhang Qiang , Yang Jinliang , Wu Weimin , Ning Shaonan , Huang Gang , Yang Yi 
Published: October 2020

Abstract
Background: Although chest wall stabilization (CWS) has been widely performed for rib fractures in the past decade in China, consensus about operative indication, timing, and technical details for CWS is not formulated yet. The aim of this study is to investigate the existing situation of surgical treatment for rib fractures in China. Methods: Four hundred and fourteen questionnaires were sent out to surgeons in different hospitals in China and collected between January 2018 and April 2018. Data were reviewed and extracted for analysis.Results: Three-hundred and seventy-one valid questionnaires were included in this study. About 14500 cases of CWS for rib fracture were performed in the investigated hospitals in 2016 and about 17600 cases in 2017. There were 38.3% hospitals performed chest wall stabilization for single rib fracture and 44.9% hospitals performed chest wall stabilization for two rib fractures. About 92.1% of CWS cases were performed within two weeks while 42.2% surgeons performed CWS for patients with rib fracture more than two weeks. CWS of was performed in 95.6% of hospitals and 93.2% cases were performed by thoracic surgeons. Nickel-titanium memory alloy and pure titanium rib embracing device are mostly used in rib fixation. Only 33.93% of surgeons chose to remove internal fixator at one year after surgery.Conclusions: Although CWS has been widely performed in China, there are many controversies on the indications, timing, and technical details of CWS. Large-scale clinical trial, high-level literature, uniform standards of surgical indications are critical for the healthy development of CWS.
Approaches for Improving Health Equity: The Effect of The Gainesville Community Resource Paramedic Program on Reducing Emergency Department Utilization
Authors: Cistola Andrew S , Bak Ariella N , Guyer Laura , Reed Austin , Rooks Ben , Chacko Lisa 
Published: October 2020

Abstract
Background. The U.S. healthcare system has consistently struggled with inefficiencies in Emergency Department (ED) usage (Enard & Ganelin, 2013). Other studies have established that interventions focusing on care coordination are not able to reduce utilization (Finkelstein, 2020), and current ED reduction programs in the literature focus on establishing patients in primary care (Raven, 2016). In community paramedicine programs, paramedics collaborate with interdisciplinary partners to address the needs of patients outside of traditional health care settings. The Gainesville Community Resource Paramedic Program (Gainesville CRP) was implemented in 2017 to provide an intervention to address social determinants that primary care providers (PCP) cannot address. Methods. A Student’s t-test for paired samples was used to compare total ED visits as well as ED visits with and without hospital admission six months before and after program enrollment. Pearson’s correlation between final change in total ED visits and total PCP visits for pre-CRP, post-CRP, and full-CRP were calculated to determine if there was evidence for bias in utilization patterns. Results. Among program participants (n = 53), significant reductions were observed among total (mean = 2.94, p < 0.001), without admission (mean = 1.30, p = 0.006), and with admission (mean = 1.64, p = 0.002). Significant reductions were also found among selected demographics and morbidities. Reductions in total ED visits were not associated with visits to a PCP before, after, or throughout. Conclusions. Gainesville CRP was able to reduce ED visits independent of PCPs indicating that the approach could inform other ED diversion programs.
Reduced β2-glycoproteinI Alleviated Rat Myocardial Ischemia/Reperfusion Injury via Mitochondrial Protection and Inhibition of Apoptosis
Authors: Zhou Saijun , Meng Zhenxing , Xiao Shumin , Cheng Ting , Huang Shuai , Yu Demin , Yu Pei 
Published: October 2020

Abstract
BackgroundMyocardial ischemia/reperfusion (I/R) injury is one of the most important reasons for death of coronary heart disease after vascular recanalization. New evidences have shown that β2-glycoprotein I (β2GPI) plays a protective role in cardiovascular diseases. This study aims to evaluate the effects of reduced β2GPI (R-β2GPI), one form of β2GPI, on myocardial I/R injury, and to explore related mechanisms. MethodsThe in vivo myocardial I/R models of Sprague Dawley rats and in vitro hypoxia/reoxygenation(H/R) models of H9c2 cells were established. The myocardial infarction and morphological changes in SD rats were measured by the TTC staining and HE staining. Creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) levels in plasma were detected by ELISA Assay kit. Terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) method and caspase-3 colorimetric assay kit were used to determine myocardial apoptosis. Intracellular reactive oxygen species (ROS) generation and mitochondrial membrane potential of H9c2 cells were measured by fluorescent probe DCFH-DA and JC-1 fluorescent staining respectively. To evaluate cell damage, cell viability was assessed by determining the release of lactate dehydrogenase (LDH). The ratio of Bcl-2/Bax at mRNA level was detected by reverse transcription-polymerase chain reaction (RT-PCR). Western blot analysis was used to detect the expression levels of total Akt and phosphorylated Akt as well as the expression levels of total GSK-3βand phosphorylated GSK-3β in H9c2 cells. ResultsOur results suggested that R-β2GPI improved I/R model rats’ heart function, decreased infarct size, reduced serum CK-MB, cTnI levels, cell apoptosis and caspase3 activity. In vitro, R-β2GPI decreased LDH leakage, reduced ROS generation, maintained mitochondrial membrane potential and increased bcl-2/bax mRNA ratio; increased phosphorylation of Akt and GSK-3β in H9c2 cells following Hypoxia/Reoxygenation (H/R) jnjury. ConclusionR-β2GPI alleviated myocardial I/R (or H/R) injury by reducing oxidative stress and inhibiting mitochondrial apoptotic pathway via increasing the phosphorylation of Akt/GSK-3β.
Autocrine Activation of Cerebral Microglia by Allograft Inflammatory Factor-1
Authors: Fukasawa Mai , Kudo Yoshihiro , Nishihara Anna , Nishio Kensuke , Itou Tomoka , Iinuma Toshimitsu , Asano Masatake 
Published: October 2020

Abstract
Allograft inflammatory factor-1 (AIF-1) is a marker for activated microglia. Unilateral common carotid artery occlusion (UCCAO) was conducted to elucidate mechanisms that regulate AIF-1 expression in C57BL/6 male mice. Immunohistochemical reactivity of microglia against anti-AIF-1 antibody was increased significantly in the brain of this model. The increased AIF-1 production was further confirmed by ELISA using brain homogenate. Real-time PCR demonstrated that the increased AIF-1 production was regulated at the transcriptional level. Serum AIF-1 levels were further examined by ELISA and marked increase was observed on Day 1 of UCCAO. To examine the influence of AIF-1, immunohistochemical staining was performed and revealed that the immunoreactivity against anti-Iba-1 antibody was significantly increased in various organs. Among them, the accumulation of Iba-1+ cells were observed prominently in the spleen. Intraperitoneal injection of minocycline, a potent microglia inhibitor, reduced the number of Iba-1+ cells suggesting microglia activation-dependent accumulation. Based on these results, AIF-1 expression was further examined in the murine microglia cell line MG6. AIF-1 mRNA expression and secretion were up-regulated when the cells were cultured under hypoxic condition. Importantly, stimulation of the cells with recombinant AIF-1 induced the expression of AIF-1 mRNA. These results suggest that increased AIF-1 production by microglia in cerebral ischemia regulate the AIF-1 mRNA expression at least in part by an autocrine manner.
WITHDRAWN: Optimization of Modular Fixture Layout by Minimizing Work-piece Deformation
Authors: Rashid Muhammad Mohsin , Khan Awais Ahmed , Qasim Muhammad , Waqas Muhammad , Ammar Muhammad , Javaid Muhammad Yasar 
Published: October 2020

Abstract
Machining fixtures are utilized to locate and restrain a workpiece during different manufacturing processes. The workpiece must be properly located and clamped in order to have it to be manufactured according to the prescribed dimensions and tolerance. The real motive of fixture design is to maximize locating accuracy and workpiece firmness while minimizing deformations. The purpose of this research work is to conduct a multi-objective optimization in order to minimize workpiece deflections due to clamping forces and optimized fixture layout by taking into consideration the boundary conditions and loads applied during a machining process. The locators are employed in a 3-2-1 fixture configuration. Then the empirical relations are used to calculate the machining forces and moments generated during drilling and milling processes and after that the workpiece is loaded to model those cutting forces. ANSYS parametric design language (APDL) code which made use of sub-approximation method is utilized to automatically optimize locator and clamp positions. Afterwards the clamping forces are being optimized using balancing force-moment method. Lastly, the maximum deformation of the workpiece against the optimum clamping forces is found by harmonic analysis.
Genome-wide identification and characterization of functionally relevant microsatellites from putative transcription factor genes of tea for efficient genotyping.
Authors: Parmar Rajni , Seth Romit , SHARMA RAM Kumar 
Published: October 2020

Abstract
Background: SSR markers derived from coding region and non-coding un-translated regions (UTRs) act as potential “functional genetic markers”. Tea, one among the most popular herbal drink with multiple medicinal properties is greatly suffered due to several bottlenecks of self-incompatibility, genome heterozygosity and long gestation period. Despite the huge genomic resources, experimentally validated functionally relevant SSR markers are still scarce in tea. Transcription factors (TFs) accounts for larger proportion of plant genomes regulating expression of various desirable traits have not been explored for development of functional marker resource in tea.Results: In current study, putative 2776 transcripts encoding TFs were identified harbouring 3687 SSR loci. High abundance of repeats in ORF (44.37%), UTRs (5'UTR: 32.57%; 3'UTR: 23.0%) suggests significant functional and regulatory relevance of novel SSR loci in trait dissection. 589 polymorphic novel experimentally validated SSR markers (ORF: 297; 5’UTR: 211; 3'UTR: 81) amplified 2864 alleles with allele numbers (Na) of 2 to 17 per locus. Interestingly, repetitive pattern of tri/hexa-repeats in coding region revealed single amino acid repeats reiteration of serine, glycine and proline, leucine in TFs of tea. Moreover, high representation of TF derived polymorphic SSR markers in bHLH (53), WRKY (37), C3H (32), and Myb-related (31) can be utilised for candidate-gene based mapping in tea. Successful utilization of polymorphic SSR makers for genetic diversity characterization of 115 tea cultivars suggests their wider utility in arge-scale fingerprinting studies. Furthermore, 185 SSR markers representing hk x hk, lm x ll, nn x np, ab x cd and ef x eg segregating patterns in selective genotyping of bi-parental mapping population can be potentially employed in genome mapping studies in tea. Conclusion: SSR repeats in regulatory genes influencing normal activity and function of the gene due to the repeat length (expansion and contraction) causing phenotypic variation in plants. Therefore, identification of first set of 1843 novel putative TFs derived microsatellite markers resource with experimentally validated potential polymorphic markers stipulates their importance in various genotyping studies in tea. Interestingly, SSRs retrieved in important TFs may have direct implications for molecular dissection desirable in tea. Genic functional markers developed in the study are powerful tools and can be potentially utilized to accelerate molecular breeding and trait dissection efforts for implantation of marker-asserted selection in tea.
Maternal Low Fasting Plasm Glucose in the Second Trimester is Associated with Neonatal Asphyxia
Authors: Shasha Yuan , Yaxin An , Yuxian Yang , Kun Li , Jing Ke , Dong Zhao 
Published: October 2020

Abstract
Background Neonatal asphyxia (NA) is associated with neonatal respiratory distress syndrome, cerebral palsy and neonatal death. Risk factors for NA have been identified as maternal hypertension, premature birth and anemia. While the effect of maternal fasting plasm glucose (FPG) in the second trimester of pregnancy on NA remains unclear. Method Retrospective data from 9661 singleton newborns and mothers were analyzed from January 2016 to July 2018 in Tongzhou district, Beijing. Multivariate logistic regression was used to investigate the risk factors of NA, adjusted for gestational hypertension, triglyceride in the second trimester of pregnancy, fetal distress in utero and preterm birth. Results Of the 9,661 newborns, 26 (2.7‰) were diagnosed with neonatal death (Apgar score 1min = 0) and 52 (5.4‰) with varying degrees of asphyxia (Apgar score 1min = 1 to 6). The asphyxia group showed lower FPG [asphyxia group vs non-asphyxia group, 4.5±0.4 vs 4.8±0.5 mmol/L, P<.01], higher triglyceride level (asphyxia group vs non-asphyxia group, 3.0±1.3 vs 2.5±1.9 mmol/L P<.01) in the second trimester, higher rates of gestational hypertension, fetal distress in utero, preterm birth than the non-asphyxia group (P<.05). Multivariate logistic regression revealed that lower FPG in the second trimester was an independent risk factor of NA [adjusted odds ratio (AOR) 0.26; 95% CI 0.08 to 0.80]. Conclusion Pregnant women with low fasting glucose in the second trimester of pregnancy are at increased risk of birth asphyxia in their offspring.
Prone position increases the risk of pancreatic fistula after laparoscopic radical gastrectomy combined with heated intraperitoneal chemotherapy: a case report
Authors: An Xing , Weng Xiangwen , Li Li , Huang Qingsong , Long Kunlan , Deng Shikun , Wang Sha , Zhi Lijia 
Published: October 2020

Abstract
Background: There has not been reported that prone position increases the risk of postoperative pancreatic fistula. We present a case of prone position leading to hyperthermia and pancreatic fistula in a patient with acute respiratory distress syndrome(ARDS) after laparoscopic radical gastrectomy(LRG) combined with heated intraperitoneal chemotherapy(HIPEC).Case presentation: A 68-year-old male developed moderate ARDS after LRG combined with HIPEC. Since low tidal volume and high positive end expiratory pressure(PEEP) ventilation could not improve oxygenation, prone ventilation was selected to improve heterogeneous lung injury. However, chills and fever appeared after the position change. Abdominal computed tomography (CT) showed that the mesenteric fat space in the middle abdomen was fuzzy, local exudation was increased, and the boundary of pancreas was not clear. The increase of amylase in peritoneal drainage fluid was 10 times higher than that in serum amylase. After communicating with the general surgeon, we learned that during the operation, the surgeon had opened the pancreatic capsule to clean the local lymph nodes. It was considered that prone position lead to the sharp increase of abdominal pressure, especially the change of peripancreatic pressure. The visceral organs of the abdominal cavity squeezed each other, the pancreatic tissue was compressed, the pancreatic juice extravasation occurred, and even aggravated the pancreatic fistula. In the follow-up treatment process, the patient were given continuous abdominal drainage and avoided prone position as far as possible. Since then, the patient's temperature tended to be stable. On the 10th day after the operation, the patient successfully withdrew from the ventilator and transferred to the general ward for further specialized treatment.Conclusion: Our case adds further concerns in ARDS patients after LRG combined with HIPEC, including the monitoring of postoperative pancreatic fistula and how to perform prone ventilation more safely.
Detection of SARS-CoV-2 on contact surfaces within shared sanitation facilities and assessment of the potential risks for COVID-19 infections
Authors: Amoah Isaac Dennis , Pillay Leanne , Deepnarian Nashia , Awolusi Oluyemi , Pillay Kriveshin , Ramlal Preshod , Kumari Sheena , Bux Faizal 
Published: October 2020

Abstract
Contamination of contact surfaces with SARS-CoV-2 has been reported as a potential route for the community transmission of COVID-19. This could be a major issue in developing countries where access to basic sanitation is poor leading to the sharing of toilet facilities. In this study, we present the first report of SARS-CoV-2 contamination on key contact surfaces in shared toilets, in the city of Durban, using droplet digital PCR and assessed the probabilistic risks of COVID-19 infections.Approximately, 53-69% of the contact surfaces were contaminated, with SARS-CoV-2 viral loads per cm2 ranging from 25.9 to 132.69 gc/cm2. Toilet seats had the highest contamination per cm2. The results suggested that the leading cause of contamination in shared toilets could be the shedding of the viral particles in feces and contaminated hands. We observed a significant reduction in viral loads on the contaminated surfaces after cleaning, showing the potential of effective cleaning on the reduction of contamination of these surfaces. The probabilistic assessment showed a high potential for COVID-19 infections. Touching the internal latch of the toilet cubicle had the highest risk of infections (4.3x10-2(6.0x10-4)) when a person uses the toilet once in a day, increasing to 1.0x10-1(1.4x10-3) for three uses in a day. The risks estimated in this study were higher than any of the tolerable/acceptable risk figures proposed for COVID-19 from environmental exposure. This calls for the implementation of risk reduction measures, such as strict adherence to wearing face masks, regular washing of hands with soap, and effective and regular cleaning.
SEJARAH GERAKAN DAKWAH ABDUL GHANI KASUBA (JIHAD PERDAMAIAN PADA KONFLIK ANTAR AGAMA DI MALUKU UTARA)
Authors: Abdullah Siti Nuralfia 
Published: October 2020

<p class="Standard"><em>The way of Islamic preaching from the time of the Prophet to the present can be said to be diverse. In its development, some famous figures, scholars, and religious teachers also emerged in their respective regions. Each figure also has a different path and experience in the preaching of all fields, including the da’wa jihad carried out by Abdul Gani Kasuba in breaking up inter-religious conflicts in North Maluku. This article uses the method of library research in which is data is taken from the main resources, namely “Sejarah Konflik dan Perdamaian di Maluku Utara</em> <em>(Refleksi Terhadap Sejarah Moloku Kie Raha)” and “Konflik Komunal: Maluku 1999-2000”. As a result, the author concludes that the substance of the missionary movement of Abdul Gani Kasuba is showing a humanist person to the community when preaching, regardless of which people he preaches. He prioritizes the characteristics of ukhuwah wathaniyah that implies the importance of brotherhood based on humanity (ukhuwah basyariah).</em></p><p class="Standard"><strong><em> </em></strong><em>.</em></p>
PEMETAAN TATA KELOLA INFRASTRUKTUR PENYIARAN RADIO SWASTA DI DKI JAKARTA
Authors: Haryono Cosmas Gatot , Pamungkas Thomas Bambang 
Published: October 2020

<p><em>The aims of this study is to conduct mapping related to the implementation of governance of private radio broadcasting in DKI Jakarta. This is interesting to do because there are many complaints from the public that the management of broadcast media in Jakarta, especially the Radio Private Broadcasting Institutions, deviates much from the rules stipulated in Law no. 32 of 2002 concerning Broadcasting. This research is a quantitative research with descriptive type that tries to see how the implementation of private radio management in Jakarta as the dependent variable. While the components seen are administrative data, broadcast program data,</em><em> facilities </em><em>and infrastructure development, and staffing data. The results obtained indicate that there are many irregularities in radio broadcasting management in DKI Jakarta, including related to share ownership by employees, time allocation for public service announcements, certified employees and ownership of standard infrastructure for broadcasting.</em></p><p> </p>
CONCEPTUALIZING THE PRINCIPLES OF SOCIAL MEDIA ENGAGEMENT: TEACHINGS FROM SELECTED VERSES OF SURAH AL-HUJURAAT
Authors: Sule Muhammad Maga , Yahaya Atiku Garba 
Published: October 2020

<p><em>The speedy advancement in internet technology has revolutionized the use of social media platforms as ways of communication globally. </em><em>This paper examines the proliferations social media sites in the world and its use among the Muslims. Unlike traditional media, most of internet based means of social interactions are user-generated. It allows the individual to determine the content of the message with or without censorship or regulation. The liberty to open an account with any site of choice and the freedom it entails, lured some Muslim</em><em>s</em><em> to surf social media without recourse to or in line with the basic tenets of Islamic teachings. The paper </em><em>is</em><em> a qualitative method where In-Depth Interviews were conducted with seasoned social users. The researchers purposively selected three participants for the study and interview because they are Muslims and possessed the knowledge about the phenomenon investigated. Some of the findings of the study revealed that some Muslims finds it convenient to share or post unsubstantiated religious messages on social media. Similarly, it has paved way for increasing number of untrained social media preachers. This makes it a delicate tool at the disposal of some of Muslim to fan antagonism among Muslim of creeds and sects in Nigeria. The article concludes that social media is a double-edged sword which side-effects as apparent when Muslim user do not resort to the teachings of Islam as the guiding principle when surfing the social media sites. The unfettered user-generated content of social media in 21<sup>st</sup> century enables the users to operate outside the ambit of the Islamic convention of social interactions.</em></p>
Multi-objective fuzzy optimization for sustainable irrigation planning
Authors: Gurav Jyotiba B. , Regulwar D. G. 
Published: October 2020

Abstract
The objective of the present work is to determine an optimal cropping pattern under uncertainty, which maximizes four objectives simultaneously, including net benefits (NBF), crop production (CPD), employment generation (EGN) and manure utilization (MUT). Except the objective of maximizing the NBF, the other objectives are related to sustainability. To deal with uncertainty, a multi-objective fuzzy linear programming (MOFLP) model has developed along with fuzziness in decision parameters (objective function coefficient, cost coefficients, technological coefficients and resources) and decision variables (area to be irrigated under each crop in each season) and applied the same to Jayakwadi Project Stage-I, Maharashtra, India. The present study is in the form of a successful attempt to deal with irrigation planning associated with sustainability and uncertainty.