bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter
Authors: Wang Lirong , Erişen Deniz E. , Yang Ke , Zhang Bingchun , Guan Hongyu , Chen Shanshan 
Published: May 2020

AbstractVascular implant interventional medical catheter will contact with blood firstly after implantation. The anticoagulation and antibacterial functions of this device will determine the success or failure. Copper (Cu) has been verified to possess multi‐biofunctions, but it was challenging to add the Cu metal to most materials. Take advantage of its functionality; Cu has been grafted on the material surface to improve the anticoagulation function and accelerate endothelialization. In this study, a Cu‐bearing chitosan coating was prepared on the catheter to endow the anticoagulation and anti‐infection functions. Besides, properties characterization and functional evaluation of the coated medical catheter were investigated. Dynamic blood clotting and platelet adhesion tests were carried out to evaluate the anticoagulation property. Besides this, the antibacterial test was used to estimate the anti‐infection function. The surface energy and Cu ions release from the coating were detected and calculated by contact angles and immersion tests, respectively. The results of attenuated total reflectance Fourier transform infrared spectroscopy (ATR‐FTIR) and X‐ray photoelectron spectroscopy (XPS) revealed that Cu ions were grafted in the chitosan coating. Thermogravimetric analysis (TA) result showed the concentration of Cu ions in the coating. The results of dynamic blood clotting, platelet adhesion, and antibacterial tests revealed that Cu grafted in chitosan would improve the blood compatibility and anti‐infection property. The surface properties and Cu ions release behavior of Cu‐bearing coating revealed the reasons for multi‐biofunctions. This study indicated that the Cu‐bearing chitosan coating could endow the vascular implant interventional device anticoagulation and anti‐infection functions, which has excellent potential for clinical application.
Detrusor bioengineering using a cell‐enriched compressed collagen hydrogel
Authors: Smolar Jakub , Nardo Daniele De , Reichmann Ernst , Gobet Rita , Eberli Daniel , Horst Maya 
Published: May 2020

AbstractObjectiveThe gold standard for bladder regeneration in end‐stage bladder disease is the use of intestinal tissue, which is however associated with significant long‐term complications. Our study aims to bioengineer functional detrusor muscle combining bladder smooth muscle cells (SMC) and SMC‐like adipose‐derived stem cells (pADSC) in compressed collagen (CC) hydrogels and to investigate biocompatibility and tissue regeneration of such detrusor‐equivalents in a rat detrusorectomy model.MethodsCompressed collagen hydrogels seeded with 1 × 106 or 4 × 106 SMC alone or in combination with pADSC in a 1:1 ratio were investigated. Morphology, phenotype, and viability as well as proteomic secretome analysis were assessed in the 1:1 co‐cultures and the respective monocultures. The hydrogels were implanted into rat bladders after partial detrusorectomy. Bladders were harvested 8 weeks after transplantation, and assessed for tissue morphology, detrusor regeneration, neo‐vascularization and ‐innervation.ResultsCo‐cultured cells exhibited native SMC morphology, high viability and proliferated to form microtissues in vitro. The pro‐angiogenic factors angiogenin, vascular endothelial growth factor (VEGF)‐A and ‐D were increased in the secretome of the pADSC samples. After 8 weeks of in vivo, the regenerated bladder wall showed a multilayered structure containing all bladder wall components. The overall performance of the bladder wall regeneration of CC seeded with 4 × 106cells was significantly better than with 1 × 106 cells and the combination SMC:pADCS performed slightly better than SMC alone.ConclusionCompressed collagen possesses an adequate regenerative potential to promote regeneration of bladder wall tissue in vivo. Seeded with a combination of pADSC and SMC this may well be the first step towards a functional bladder reconstruction especially in patients suffering of end‐stage bladder diseases.
Novel halogenated cyclopentasilylene‐2,4‐dienes via DFT
Authors: Ayoubi‐Chianeh Mojgan , Kassaee Mohamad Z. 
Published: May 2020

AbstractIn view of immense importance of silylenes and the fact that their properties undergo significant changes on substitution with halogens, here, we have used B3LYP/6‐311++G** level of theory to access the effects of 1–4 halogens (X = F, Cl, Br, and I) on four unprecedented sets of cyclopentasilylene‐2,4‐dienes; with the following formulas: SiC4H3X (1
X), SiC4H2X2 (2
X), SiC4HX3 (3
X), and SiC4X4 (4
X). In going down from F to I, the singlet (s)‐triplet (t) energy gap (ΔEs‐t, a possible indication of stability), and band gap (ΔEH‐L) decrease while nucleophilicity (N), chemical potential (μ), and proton affinity (PA) increase. The overall order of N, μ, and PA for each X is 2
X > 1
X > 3
X > 4
X. Precedence of 2
X over 1
X is attributed to the symmetric cross conjugation in the former. The highest and lowest N are shown by 2
I and 4
F. The trend of divalent angle () for each X is 4
X > 1
X > 3
X > 2
X. The results show that in going from electron withdrawing groups (EWGs) to electron donating groups (EDGs), the ΔEs‐t and ΔEH‐L decrease while N, μ, and PA increase. Also, rather high N of our scrutinized silylenes may suggest new promising ligands in organometallic chemistry.
Eukaryotic initiation factor 3B is overexpressed and correlates with larger tumor size, advanced FIGO stage, and shorter overall survival in epithelial ovarian cancer patients
Authors: Zhao Nannan , Guo Yanjuan , He Yanfang , Chen Yan , Xing Jun 
Published: May 2020

AbstractBackgroundThis study aimed to detect the eukaryotic initiation factor 3B (EIF3B) expression and explore its correlation with clinical features and prognosis in epithelial ovarian cancer (EOC) patients.MethodsA total of 230 primary EOC patients underwent surgery treatment were retrospectively reviewed. Immunohistochemical (IHC) assay was used to determine EIF3B expression in tumor and adjacent tissue specimens of all patients. According to the total IHC score, the expression of EIF3B was classified as low expression and high expression, and the latter was further divided into 3 grades: high+, high++, and high+++ expressions. Overall survival (OS) was calculated.ResultsEukaryotic initiation factor 3B expression was increased in tumor tissue compared with adjacent tissue. Tumor EIF3B high expression correlated with larger tumor size (>10 cm), lymphatic metastasis, and advanced International Federation of Gynecology and Obstetrics stage (FIGO) (III/IV). Besides, OS was decreased in patients with tumor EIF3B high expression compared with patients with tumor EIF3B low expression, and further analysis showed that the OS was shortest in patients with tumor EIF3B high+++ expression, followed by patients with tumor EIF3B high++ expression and patients with tumor EIF3B high + expression, and the longest in patients with tumor EIF3B low expression. Additionally, higher tumor EIF3B expression, peritoneal cytology (positive), ascites volume (>100 mL), differentiation (poor vs. well/moderate), tumor size (>10 cm), FIGO stage (III/IV vs. I/II), and cancer antigen 125 (>1000 U/mL) independently predicted shorter OS.ConclusionEukaryotic initiation factor 3B exhibits a clinical value for monitoring disease progression and predicting prognosis in EOC patients.
Novel potential tumor biomarkers: Circular RNAs and exosomal circular RNAs in gastrointestinal malignancies
Authors: Wang Yezhao , Li Zhe , Xu Suyuan , Guo Junming 
Published: May 2020

AbstractBackgroundCircular RNAs (circRNAs) are structural ubiquitous RNA molecules. Accumulating evidences have elucidated that circRNAs play essential roles in the pathogenesis of diseases including cancers. Exosomal circRNAs are those circRNAs stably existing in exosomes and having high clinical values as novel potential diagnostic biomarkers of many diseases. Gastrointestinal (GI) malignancies, including pancreatic cancer, colorectal cancer, hepatocellular carcinoma (HCC), and gastric cancer, are leading causes of mortality worldwide and a major global health burden. However, no ideal tumor biomarkers of screening early GI cancers are currently available.MethodsWe collected data through Web of Science. The search terms used were as follows: circular RNA, circRNA, exosomes, exosomal circRNAs, biomarkers, gastrointestinal malignancies, pancreatic cancer, hepatocellular carcinoma, HCC, gastric cancer, colorectal cancer, physiological functions, biogenesis, molecular mechanism. Only articles published in English were included.ResultsWe found that several circRNAs and exosomal circRNAs have been used as potential biomarkers to screen GI cancers including pancreatic cancer (hsa_circ_0001649, circ_0007534, circ_0030235, circRHOT1, circZMYM2, circ‐LDLRAD3, chr14:101402109‐101464448C, chr4:52729603‐52780244C, circ‐IARS, and circ‐PDE8A), HCC (circSETD3, circADAMTS13, hsa_circ_0007874, hsa_circ_104135, circFBLIM1, cSMARCA5, circRNA‐100338, and circPTGR1), colorectal cancer (hsa_circ_0001178, hsa_circ_0000826, hsa_circ_0004771, circDDX17, circITGA7, and circHIPK3), and gastric cancer (hsa_circ_0074362, circNRIP1, circAKT3, circ‐DONSON, circPSMC3, circ‐KIAA1244, circPVRL3, circPVT1, hsa_circ_0000096, ciRS‐133, hsa_circ_0001017, and hsa_circ_0061276).ConclusionCircRNAs and exosomal circRNAs have the potential high clinical diagnostic values for GI malignancies.
Rapid telepsychology deployment during the COVID‐19 pandemic: A special issue commentary and lessons from primary care psychology training
Authors: Perrin Paul B. , Rybarczyk Bruce D. , Pierce Bradford S. , Jones Heather A. , Shaffer Carla , Islam Leila 
Published: May 2020

AbstractObjectiveThis article positions the special issue on telepsychology amidst the COVID‐19 pandemic, which has dramatically accelerated the adoption and dissemination of telepsychology.MethodThe article makes general observations about the themes emerging in the special issue with considerations for application, training, theory‐driven research, and policy. It then presents as a case example the rapid deployment during the pandemic of telepsychology doctoral training and services at the Virginia Commonwealth University (VCU) Primary Care Psychology Collaborative.ResultsFacilitators to VCU telepsychology deployment included trainee and supervisor resources, strong telepsychology training, and prior experience. Barriers to overcome included limited clinic capacity, scheduling, technology, and accessibility and diversity issues. Lessons learned involved presenting clinical issues, supervision, and working with children and adolescents.ConclusionsTelepsychology is crucial for psychological service provision, during the COVID‐19 pandemic more than ever, and that is unlikely to change as psychologists and patients increasingly continue to appreciate its value.
The P2Y6 receptor signals through Gαq/Ca2+/PKCα and Gα13/ROCK pathways to drive the formation of membrane protrusions and dictate cell migration
Authors: Girard Mélissa , Dagenais Bellefeuille Steve , Eiselt Émilie , Brouillette Rebecca , Placet Morgane , Arguin Guillaume , Longpré Jean‐Michel , Sarret Philippe , Gendron Fernand‐Pierre 
Published: May 2020

AbstractCell migration is a ubiquitous process necessary to maintain and restore tissue functions. However, in cancer, cell migration leads to metastasis development and thus worsens the prognosis. Although the mechanism of cell migration is well understood, the identification of new targets modulating cell migration and deciphering their signaling events could lead to new therapies to restore tissue functions in diseases, such as inflammatory bowel disease, or to block metastatic development in different forms of cancer. Previous research has identified the G‐protein‐coupled P2Y6 receptor as an innovative target that could dictate cell migration under normal and pathological conditions. Surprisingly, there is little information on the cellular events triggered by activated P2Y6 during cell migration. Here, we demonstrated that P2Y6 activation stimulated A549 human lung cancer cells and Caco‐2 colorectal cancer cell migration. Activated P2Y6 increased the number of filopodia and focal adhesions; two migratory structures required for cell migration. The generation of these structures involved Gαq/calcium/protein kinases C (PKC) and Gα13/RHO‐associated protein kinase‐dependent pathways that dictate the formation of the migratory structures. These pathways led to the stabilization of the actin cytoskeleton through a PKC‐dependent phosphorylation of cofilin. These results support the idea that the P2Y6 receptor represents a target of interest to modulate cell migration and revealed an intricate dialogue between two Gα‐protein signaling pathways.
Comparing the risk of hypothyroidism in HCV patients treated with different DAA drugs combinations (sofosbuvir + interferon + ribavirin and sofosbuvir + daclatasvir + ribavirin)
Authors: Wahid Braira , Shami Khadija , Joiya Salman A. , Özuyar Sevilay E. G. , Idrees Muhammad 
Published: May 2020

AbstractThe recent development of direct‐acting antiviral (DAA) drugs has revolutionized the area of hepatitis C virus (HCV) therapeutics but the efficacy and clinical outcome of interferon (IFN)‐free therapy have not been extensively studied yet. We observed a dramatic increase in hypothyroidism among patients treated with sofosbuvir, IFN, and ribavirin. This is the first prospective study of the thyroid dysfunction in DAA drugs treated patients. This study compared the risk of hypothyroidism in two different groups of HCV patients treated with different DAA drugs regimens that were sofosbuvir + pegylated‐IFN‐α + ribavirin and sofosbuvir + daclatasvir + ribavirin. Our findings highlight the periodic screening of serum thyroid‐stimulating hormone and T4 levels in HCV infected patients during the treatment and posttreatment.
Predictability of the mid‐summer surface air temperature over the Yangtze River valley in the National Centers for Environmental Prediction Climate Forecast System
Authors: Tang Shankai , Qiao Shaobo , Feng Taichen , Jia Zikang , Zang Naihui , Feng Guolin 
Published: May 2020

AbstractBy using the hindcast and forecast data from the National Centers for Environmental Prediction Climate Forecast System version 2 (NCEP CFSv2) for the 1982–2018 period, we investigate the forecasting skills of the mid‐summer (July and August) surface air temperature (SAT) at interannual timescales in this study. Although CFSv2 predictions show a warm bias for the climatological mean SAT over the Yangtze River valley (25°–32°N, 105°–122°E), they show a consistent and great performance in predicting the interannual variability of the mid‐summer SAT over this region until 4 months in advance, where the linear correlation coefficient between the predicted and observed time series reaches +0.65, +0.51 and + 0.68 for 4, 2 and 0 months in advance, respectively. The CFSv2 predictions well simulate the linkage between the SAT anomalies over the Yangtze River valley and the anomalous atmospheric circulation aloft, including the circumglobal teleconnection and zonal extension of the Western Pacific Subtropical High. However, CFSv2 has trouble in simulating the associated vertical velocity, cloud cover and solar radiation anomalies, except for 0 months in advance. The persistent forecasting skills result from the accurate response of the circumglobal teleconnection and Western Pacific Subtropical High to the El Niño/Southern Oscillation and sea surface temperature (SST) anomalies over the mid‐latitude North Atlantic. Correspondingly, the forecasting skill, signal and signal‐to‐noise ratio are effectively improved in the years with strong mid‐summer SST anomalies over the tropical central‐eastern Pacific or mid‐latitude North Atlantic. These results are useful for understanding the predictability of the mid‐summer SAT over the Yangtze River valley.
A new advanced packaging system for extending the shelf life of refrigerated farmed fish fillets
Authors: Navarro‐Segura Laura , Ros‐Chumillas María , Martínez‐Hernández Ginés Benito , López‐Gómez Antonio 
Published: May 2020

AbstractBACKGROUNDAn innovative pilot‐plant packaging was developed and evaluated for applying oregano essential oil (OEO) vapours in conditions of high vacuum for exploring the antimicrobial effect of essential oil vapours applied immediately before packaging of fish fillets. Farmed sea bream (Sparus aurata) fresh fillets have been used as a model for validating this new technology. These fillets, as a refrigerated product under modified atmosphere packaging (MAP), have a relatively short shelf life (12–14 days) mainly due to the fast microbial growth. The effects of conventional OEO dippings [pretreatment dipping (0.1% of OEO) of whole fish (T1) and filleted sea bream (T2)] were compared with the OEO application in vapour phase (67 μL L‐1) under vacuum (5–10 hPa) immediately before MAP fillet packaging (T3).RESULTST3/T2 samples showed the lowest microbial growth after 28 days at 4 °C, with loads up to 1/2.6 log units for Enterobacteria/lactic acid bacteria compared to untreated samples. The initial trimethylamine nitrogen (TMA‐N) content (2.6 mg kg−1) increased in T1 and T2/T3 samples by 9.6 and 6/7 units, respectively, after 28 days. Quality Index Method (QIM) better reflected the fish fillets shelf life than texture and colour measurements. The shelf life of T3/T2 samples was established in at least 28 days (4 °C), while the QIM threshold (6) was exceeded after 7/21 days in untreated/T1 fillets.CONCLUSIONThe fish shelf life was extended with vapour OEO treatment using this new technology, similarly to OEO dipping treatment, according to QIM, corroborated by the microbial quality and TMA‐N contents. © 2020 Society of Chemical Industry
Almond by‐product composition impacts the rearing of black soldier fly larvae and quality of the spent substrate as a soil amendment
Authors: Palma Lydia , Fernández‐Bayo Jesus , Putri Ferisca , VanderGheynst Jean S 
Published: May 2020

AbstractBACKGROUNDInsect biomass is a sustainable alternative to traditional animal feeds, particularly when insects are produced on low‐value high‐volume agricultural by‐products. Seven samples of almond by‐product (hulls and shells) were obtained from processors in California and investigated for larvae production. Experiments were completed with and without larvae and spent substrate samples were assessed for their potential as soil amendments based on standard compost quality indicators.RESULTSOn average, specific larvae growth and average larval harvest weight were 158% and 109% higher, respectively, when larvae were reared on Monterey and pollinator hulls compared to nonpareil hulls and mixed shells. Larvae methionine and cystine contents were highest when larvae were reared on Monterey hulls and mixed shells, respectively. Available phytonutrients in spent substrate were affected by feedstock sample and larvae rearing. Spent nonpareil substrate without larvae had the highest NH4‐N levels and spent pollinator substrate incubated without larvae had the highest PO4‐P levels. Spent mixed shell substrate had the lowest availability of phytonutrients.CONCLUSIONThe findings demonstrate that by‐product composition has a significant impact on larvae growth and the properties of the spent substrate, and that spent substrate from larvae rearing requires further stabilization before application as a soil amendment. © 2020 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Midtrimester Ultrasound Predictors of Small‐for‐Gestational‐Age Neonates
Authors: Patel Vishal , Resnick Karen , Liang Cynthia , Smith Matthew , Haghpeykar Haleh Sangi , Mastrobattista Joan M. , Gandhi Manisha 
Published: May 2020

ObjectivesTo determine whether a specific estimated fetal weight (EFW) or abdominal circumference (AC) measurement percentile at the 18‐to 24‐week ultrasound (US) examination is associated with a small‐for‐gestational‐age (SGA) neonate.MethodsA retrospective case–control study was conducted including women with uncomplicated singleton gestations who delivered a term SGA neonate identified as having a birth weight (BW) below the 10th percentile on the Olsen growth curve and had an 18‐ to 24‐week US examination in our database. The study period was October 2011 to January 2018. A similar number of control charts were requested randomly over the same time with BW in the 10th to 90th percentiles, all which had an 18‐to 24‐week US examination in our database. After all neonates meeting BW criteria were identified, a chart review was performed to specifically evaluate biometric parameters from the US at 18 to 24 weeks to determine a potential correlation with the EFW percentile and AC percentile. Pregnancy, neonatal outcomes, and maternal demographic characteristics were collected.ResultsA total of 549 term neonates with a BW below the 10th percentile, and 593 control term neonates with BW in the of 10th to 90th percentiles were reviewed. Our analyses revealed that the AC and EFW percentiles were poor predictors of BW (<10th percentile; areas under the receiver operating characteristic curves, 0.68 and 0.69, respectively). A similar low ability of AC and EFW to predict BW below the 5th percentile was noted.Conclusions(1) No tipping point or cutoff for the EFW or AC percentile at the 18‐ to 24‐week US examination was identified to predict a term SGA neonate. (2) These data are helpful when counseling women in midgestation about specific parameters, their importance, and the potential need for follow up imaging.
Understanding the Final Disposition of Livers Declined After the Start of Procurement: A Nationwide Organ Procurement Organization Effort
Authors: Neidlinger Nikole A. , Brown Christopher , Wood Patrick , Traseger Jeff , Lebovitz Dan , Cauwels Roxane , Syed Shareef , Parekh Justin R. , Roll Garrett R. 
Published: May 2020

Declining a liver offer during organ procurement likely increases the risk of discard, but the specifics around late reallocation remain obscure. This voluntarily submitted, prospectively collected data describe late declines and the ultimate disposition of 893 livers. Once a liver suffered an intraoperative decline, only 49% of recovered livers were transplanted. Livers declined ≥80 minutes prior to cross‐clamp were transplanted 80% of the time versus livers declined ≥80 minutes after cross‐clamp, which were transplanted 45% of the time. The final disposition of these livers was into a predetermined backup patient (51%) or required an out‐of‐sequence expedited allocation (42%). Prerecovery imaging and prerecovery biopsy did not influence the ability to reallocate a liver, and livers from donors after circulatory death are rarely successfully reallocated. In conclusion, this study begins to shed light on this seemingly common practice. A total of 85% of centers had an intraoperative decline, but 4% of centers accounted for 25% of the declines. Organ procurement organizations often enter expedited liver allocation, and instituting a cross‐clamp delay to allow for reallocation may influence the disposition of these liver grafts. Expedited allocation was more time consuming than allocation into a predetermined backup. Although a certain number of intraoperative declines probably suggests a healthy amount of donor selection aggressiveness at the time of the initial organ offer, the 47% risk of discard of livers declined intraoperatively suggests that United Network for Organ Sharing should consider systematically collecting data about intraoperative declines so we can learn more about this event that influences organ utilization.