bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global research trends in complex oral sensitivity disorder: A systematic bibliometric analysis of the structures of knowledge
Authors: Fortuna Giulio , Aria Massimo , Piscitelli Alfonso , Mignogna Michele D. , Klasser Gary D. 
Published: June 2020

AbstractObjectivesA systematic bibliometric analysis of the structure of knowledge was performed to investigate the co‐word analysis, the co‐citation analysis, and the social network analysis regarding complex oral sensitivity disorder (COSD).MethodsWeb of Science database from 1985 to 2018 was systematically searched to identify all relevant articles using the MeSH terms “complex oral sensitivity disorder” and all synonyms used in the literature. We included original articles, review articles, letters to the editor, and book chapters in the English language and in 27 different ISI categories of medical sciences. Several bibliometric indicators were used.ResultsThe co‐word analysis identified 741 KeyWords Plus (KWP) grouped into 4 different clusters. The terms “pain,” “management,” “prevalence,” and “efficacy” reached the highest centrality, whereas the top 10 KWP had a frequency of 7%‐29% in 443 articles. Over a period of 32 years, a complex thematic evolution occurred, going from 2 to 6 different themes, and the KWP migration rate from one cluster to another ranged from 11% to 100%. The co‐citation network analysis based on the complete reference list (5932 references) of 443 articles identified only 2 clusters for journals, authors, and articles. The most prominent co‐cited journal was “Oral Surgery Oral Medicine Oral Pathology” (centrality: 171.75), the most co‐cited author was “Grushka M” (centrality: 330.95), and the most co‐cited article was “Grushka M. Oral Surg Oral Med Oral Pathol (1987) 63:30‐36” (centrality: 269.79). On the other hand, the direct citation network revealed that “Scala A et al, 2003” reached both the highest global citation score (GCS = 231) and local citation score (LCS = 161). Lastly, the social network analysis revealed an isolated collaboration among groups of authors, or countries or institutions. The worldwide collaboration analysis indicated that United States‐Israel and United Kingdom‐Italy were the most collaborative countries.ConclusionsThe structure of knowledge of publications on COSD revealed that research in this field has been dominated by few core topics and a limited collaboration among authors and institutions from different countries. More multicenter studies on COSD are warranted in the near future when launching new projects.
Country‐level correlates of the Dark Triad traits in 49 countries
Authors: Jonason Peter K. , Żemojtel‐Piotrowska Magdalena , Piotrowski Jarosław , Sedikides Constantine , Campbell W. Keith , Gebauer Jochen E. , Maltby John , Adamovic Mladen , Adams Byron G. , Kadiyono Anissa Lestari , Atitsogbe Kokou A. , Bundhoo Harshalini Y. , Bălțătescu Sergiu , Bilić Snežana , Brulin Joel Gruneau , Chobthamkit Phatthanakit , Del Carmen Dominguez Alejandra , Dragova‐Koleva Sonya , El‐Astal Sofián , Esteves Carla Sofia , Labib M. Eldesoki Walaa , Gouveia Valdiney V. , Gundolf Katherine , Ilisko Dzintra , Jauk Emanuel , Kamble Shanmukh V. , Khachatryan Narine , Klicperova‐Baker Martina , Knezovic Emil , Kovacs Monika , Lei Xuejun , Liik Kadi , Mamuti Agim , Moreta‐Herrera Carlos Rodrigo , Milfont Taciano L. , Wei Ong Chin , Osin Evgeny , Park Joonha , Petrovic Boban , Ramos‐Diaz Jano , Ridic Goran , Qadir Abdul , Samekin Adil , Sawicki Artur , Tiliouine Habib , Tomsik Robert , Umeh Charles S. , van den Bos Kees , Van Hiel Alain , Uslu Osman , Wlodarczyk Anna , Yahiiaev Illia 
Published: June 2020

AbstractObjectivesThe Dark Triad traits (i.e., narcissism, psychopathy, Machiavellianism) capture individual differences in aversive personality to complement work on other taxonomies, such as the Big Five traits. However, the literature on the Dark Triad traits relies mostly on samples from English‐speaking (i.e., Westernized) countries. We broadened the scope of this literature by sampling from a wider array of countries.MethodWe drew on data from 49 countries (N = 11,723; 65.8% female; AgeMean = 21.53) to examine how an extensive net of country‐level variables in economic status (e.g., Human Development Index), social relations (e.g., gender equality), political orientations (e.g., democracy), and cultural values (e.g., embeddedness) relate to country‐level rates of the Dark Triad traits, as well as variance in the magnitude of sex differences in them.ResultsNarcissism was especially sensitive to country‐level variables. Countries with more embedded and hierarchical cultural systems were more narcissistic. Also, sex differences in narcissism were larger in more developed societies: Women were less likely to be narcissistic in developed (vs. less developed) countries.ConclusionsWe discuss the results based on evolutionary and social role models of personality and sex differences. That higher country‐level narcissism was more common in less developed countries, whereas sex differences in narcissism were larger in more developed countries, is more consistent with evolutionary than social role models.
Anti‐inflammatory and macrophage polarization effects of Cranberry Proanthocyanidins (PACs) for periodontal and peri‐implant disease therapy
Authors: Galarraga‐Vinueza Maria Elisa , Dohle Eva , Ramanauskaite Ausra , Al‐Maawi Sara , Obreja Karina , Magini Ricardo , Sader Robert , Ghanaati Shahram , Schwarz Frank 
Published: June 2020

AbstractBackground and ObjectiveMacrophages’ cytokine expression and polarization play a substantial role in the host's “destructive” inflammatory response to periodontal and peri‐implant pathogens. This study aimed to evaluate cell viability, anti‐inflammatory activity, and macrophage polarization properties of different cranberry concentrates.MethodsTHP‐1 cells (monocytic line) were treated with phorbol myristic acid to induce macrophage differentiation. Human gingival fibroblasts (HFIB‐G cell line), osteosarcoma‐derived osteoblasts (SAOS‐2 cell line), and induced macrophages were treated with cranberry concentrates at 25, 50, and 100 µg/mL for 120 seconds, 1 hour and 24 hours. Untreated cells at the same time points served as controls. For anti‐inflammatory analysis, induced macrophages exposed to cranberry concentrates (A‐type PACs) were stimulated with lipopolysaccharides (LPS) derived from E coli for 24 hours. Cell viability, interleukin (IL)‐8, IL‐1 ß, IL‐6, and IL‐10 expression of LPS‐stimulated macrophages, and macrophage polarization markers were evaluated through determination of live‐cell protease activity, enzyme‐linked immunosorbent assay, and immunofluorescence staining semi‐quantification.ResultsCranberry concentrates (A‐type PACs) did not reduce HGF, SAOS‐2, and macrophage viability after 24 hours of exposure. Pro‐inflammatory cytokine expression (ie IL‐8 and IL‐6) was downregulated in LPS‐stimulated macrophages by cranberry concentrates at 50 and 100 µg/mL. Anti‐inflammatory IL‐10 expression was significantly upregulated in LPS‐stimulated macrophages by cranberry concentrates at 100 µg/mL after 24 hours of exposure. M1 polarization significantly decreased when LPS‐stimulated macrophages were exposed to cranberry concentrates. High levels of positive M1 macrophages were present in all untreated control groups. M2 polarization significantly increased at all LPS‐stimulated macrophages exposed to cranberry concentrates for 1 and 24 hours.ConclusionCranberry‐derived proanthocyanidins may have the potential to act as an anti‐inflammatory component in the therapy of periodontal and peri‐implant diseases.
Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor
Authors: Al Suraih Mohammed S. , Trussoni Christy E. , Splinter Patrick L. , LaRusso Nicholas F. , O’Hara Steven P. 
Published: June 2020

AbstractBackground & AimsPrimary sclerosing cholangitis (PSC) is a chronic liver disease characterized by peribiliary inflammation and fibrosis. Cholangiocyte senescence is a prominent feature of PSC. Here, we hypothesize that extracellular vesicles (EVs) from senescent cholangiocytes influence the phenotype of target cells.MethodsEVs were isolated from normal human cholangiocytes (NHCs), cholangiocytes from PSC patients and NHCs experimentally induced to senescence. NHCs, malignant human cholangiocytes (MHCs) and monocytes were exposed to 108 EVs from each donor cell population and assessed for proliferation, MAPK activation and migration. Additionally, we isolated EVs from plasma of wild‐type and Mdr2−/− mice (a murine model of PSC), and assessed mouse monocyte activation.ResultsEVs exhibited the size and protein markers of exosomes. The number of EVs released from senescent human cholangiocytes was increased; similarly, the EVs in plasma from Mdr2−/− mice were increased. Additionally, EVs from senescent cholangiocytes were enriched in multiple growth factors, including EGF. NHCs exposed to EVs from senescent cholangiocytes showed increased NRAS and ERK1/2 activation. Moreover, EVs from senescent cholangiocytes promoted proliferation of NHCs and MHCs, findings that were blocked by erlotinib, an EGF receptor inhibitor. Furthermore, EVs from senescent cholangiocytes induced EGF‐dependent Interleukin 1‐beta and Tumour necrosis factor expression and migration of human monocytes; similarly, Mdr2−/− mouse plasma EVs induced activation of mouse monocytes.ConclusionsThe data continue to support the importance of cholangiocyte senescence in PSC pathogenesis, directly implicate EVs in cholangiocyte proliferation, malignant progression and immune cell activation and migration, and identify novel therapeutic approaches for PSC.
A New Method for Evaluating Knowledge, Beliefs, and Neuromyths About the Mind and Brain Among Italian Teachers
Authors: Tovazzi Alice , Giovannini Serena , Basso Demis 
Published: June 2020

ABSTRACTTeachers often face situations that require them to apply knowledge about the mind and brain to education. Past studies have indicated that even if teachers show interest in cognitive neuroscience, they show high rates of adhesion to neuromyths. In the most commonly used questionnaire, however, respondents do not compare neuromyths and correct information based on neuroscience. The present study proposes a multiple‐choice questionnaire that presents scenarios occurring in school. The most commonly used and the new questionnaire were administered to 174 Italian teachers. In the most commonly used questionnaire, teachers generally had the same likelihood of accepting neuromyths as the literature reports. In the new questionnaire, the levels of both general knowledge and beliefs about neuromyths were significantly lower. Moreover, it suggests that teachers' adhesion to neuromyths in realistic situations does not match their explicit beliefs. Thus, the present research proposes that the use of questions based on feasible scenarios is a useful method to assess neuromyths.
Arabic Diacritics and Their Role in Facilitating Reading Speed, Accuracy, and Comprehension by English L2 Learners of Arabic
Authors: MIDHWAH ALI AL , ALHAWARY MOHAMMAD T. 
Published: June 2020

AbstractThe present study investigated the role of Arabic diacritics in word recognition and their impact on Arabic L2 learners’ reading speed, accuracy, and comprehension at different stages of Arabic L2 acquisition. Fifty‐four English L2 learners of Arabic from 3 proficiency levels (beginner, intermediate, and advanced) participated in the study. They belonged to 2 sets of groups: half with exposure to instructional materials containing diacritics, vowelized textbook (VT), and the other half with exposure to instructional materials not containing diacritics, un‐vowelized textbook (UVT). Participants performed word‐list reading, text reading, and target‐word comprehension tasks under vowelized (V) and un‐vowelized (UV) conditions. The results revealed participants in all VT groups did consistently better than their UVT counterparts. This positive role of diacritics in terms of Arabic word recognition and reading performance implies that inclusion of diacritics in words and texts within instructional materials does not only benefit Arabic L2 learners by removing ambiguity from words, but it also positively impacts their reading and pronunciation performance in general. The study findings and pedagogical implications are also relevant to other languages, such as Farsi and Hebrew, which exhibit similar orthographic features.
Use of hydraulic traits for modeling genotype‐specific acclimation in cotton under drought
Authors: Wang Diane R. , Venturas Martin D. , Mackay D. Scott , Hunsaker Douglas J. , Thorp Kelly R. , Gore Michael A. , Pauli Duke 
Published: June 2020

Summary

Understanding the genetic and physiological basis of abiotic stress tolerance under field conditions is key to varietal crop improvement in the face of climate variability. Here, we investigate dynamic physiological responses to water stress in silico and their relationships to genotypic variation in hydraulic traits of cotton (Gossypium hirsutum), an economically important species for renewable textile fiber production.

In conjunction with an ecophysiological process‐based model, heterogeneous data (plant hydraulic traits, spatially‐distributed soil texture, soil water content and canopy temperature) were used to examine hydraulic characteristics of cotton, evaluate their consequences on whole plant performance under drought, and explore potential genotype × environment effects.

Cotton was found to have R‐shaped hydraulic vulnerability curves (VCs), which were consistent under drought stress initiated at flowering. Stem VCs, expressed as percent loss of conductivity, differed across genotypes, whereas root VCs did not. Simulation results demonstrated how plant physiological stress can depend on the interaction between soil properties and irrigation management, which in turn affect genotypic rankings of transpiration in a time‐dependent manner.

Our study shows how a process‐based modeling framework can be used to link genotypic variation in hydraulic traits to differential acclimating behaviors under drought.
Lycopene reduces the impacts of aquatic environmental pollutants and physical stressors in fish
Authors: Dawood Mahmoud A.O. , Abdel‐Tawwab Mohsen , Abdel‐Latif Hany M.R. 
Published: June 2020

AbstractAquatic organisms are susceptible throughout their lives to chemical and physical stressors, which negatively affect their health. Various aquatic pollutants derived from industrial effluents, overuse of some agricultural pesticides, herbicides and insecticides may cause devastating toxicological aspects of aquatic organisms and deteriorate their health and growth. They also led to oxidative stress to fish due to the stimulation of the production of reactive oxygen species. Therefore, the need for using natural antioxidants to be used as feed additives is of great importance to counteract the hazardous oxidative stress responses. The use of phytochemicals, which characterized by substantial antioxidative effects, has been raised. Lycopene is the principal carotenoid pigment found in tomatoes and their products, vegetables and red fruits. Numerous studies have recommended the use of lycopene as a powerful antioxidant to attenuate the oxidative stress responses in several fish species exposed to various toxicants or any other stress conditions. Lycopene maintains the health condition of fish by enhancing the immune and antioxidative responses. This review article aimed to elucidate the current information about the potential use of dietary lycopene for several fish species and its capability to attenuate the oxidative stress and haemato‐immunological alterations resulted from aquatic environmental pollutants and other physical stressors. Additionally, the review discusses some aspects regarding the lycopene mode of action to assess the profits that would be of importance in the aquaculture industry.
High‐frequency (20 MHz) high‐intensity focused ultrasound: New Treatment of actinic keratosis, basal cell carcinoma, and Kaposi sarcoma. An open‐label exploratory study
Authors: Serup Jørgen , Bove Torsten , Zawada Tomasz , Jessen Alexander , Poli Mattia 
Published: June 2020

AbstractBackgroundSkin cancer is common, growing, challenging, and in need of progress in early‐stage treatment. 20 MHz high‐intensity focused ultrasound (HIFU) is new and applied to actinic keratosis (AK) and skin cancers for the first time. HIFU of lower frequency is already used in the treatment of internal cancers.Materials and MethodsEight patients with 201 AK lesions, one patient with 7 basal cell carcinomas (reoccurrences after PDT), and one patient with 7 Kaposi sarcoma lesions (4 treated with radiotherapy in the past) were given 1‐3 HIFU treatments. Twenty megahertz HIFU was dosed as 150 ms at 0.6‐1.2 J/shot applied to target lesions. Probes with different target depths were available. The preferred shot energy and focal depth in AK were 0.9 J and 1.3 mm. A “Sandwich” strategy with HIFU applied in two depths were tried in cancers. The follow‐up period was 3‐6 months.ResultsAll AK cleared except 5, giving a cure rate of 97%. Post‐treatment lesion healed in 1‐2 weeks with no scar. VAS pain was from 1 to 8, and in any case less than experienced with previous PDT. In both basal cell carcinoma (BCC) and sarcoma, healing was confirmed by histological verification.Discussion/conclusion20 MHz HIFU was an effective and safe treatment of AK. This new treatment, applicable to any anatomical site, has promising advantages relative to PDT and has the potential to replace or supplement PDT in future. Case‐observations indicated that HIFU can be useful in skin cancers as well.
Article placement order in rheumatology journals: a content analysis
Authors: Stewart Sarah , Gamble Greg , Grey Andrew , Dalbeth Nicola 
Published: June 2020

ObjectivesTo analyse variables associated with article placement order in serial rheumatology journals.DesignContent analysis.SettingOriginal articles published in seven rheumatology journals from 2013 to 2018.Primary and secondary outcome measuresThe following data were extracted from 6787 articles: order number of article in issue, gender of first and last author, geographical region, industry funding, research design and disease category. Cumulative density function plots were used to determine whether article placement distribution was different from the expected distribution. ORs for articles published in the first three places of an issue compared with the last three places were calculated. Altmetric Score and downloads were meta-analysed.ResultsArticle placement order did not associate with author gender or geographical region but was associated with funding source and research design. In addition, articles about rheumatoid arthritis were more likely to be ordered at the front of issues (p<0.001). Articles about crystal arthritis, systemic lupus erythematosus, vasculitis, pain syndromes and paediatric rheumatic diseases were more likely to be ordered at the end of issues (all p<0.001). Association of article placement order with disease category was observed only in journals with tables of contents grouped by disease. Articles ordered in the first three places had higher Altmetric and download rates, than articles in the last three places.ConclusionsAuthor gender and geographical region do not influence article placement order in serial rheumatology journals. However, bias for certain disease categories is reflected in article placement order. Editorial decisions about article placement order can influence the prominence of diseases.
Patients’ use and experiences with e-consultation and other digital health services with their general practitioner in Norway: results from an online survey
Authors: Zanaboni Paolo , Fagerlund Asbjørn Johansen 
Published: June 2020

ObjectivesTo explore patients’ use and experiences with four digital health services implemented in Norway to enable electronic communication between patients and their general practitioner (GP): (1) electronic booking of appointments; (2) electronic prescription renewal; (3) electronic contact with the GP’s office for non-clinical inquiries; and (4) e-consultation for clinical inquiries.DesignAn online survey consisting of quantitative data supplemented by qualitative information was conducted to explore: (1) characteristics of the users; (2) use; (3) experiences, perceived benefits and satisfaction; and (4) time spent using the digital health services.SettingPrimary care.Participants2043 users of the digital health services answering the survey.ResultsThere was a higher proportion of women, younger adults and digitally active citizens with high education. Electronic booking of appointments was the most used service (66.4%), followed by electronic prescription renewal (54.3%). Most users (80%) could more easily and efficiently book an appointment electronically than by phone. Over 90% of the respondents thought that it was easier to renew a prescription electronically, 76% obtained a better overview of their medications and 46% reported higher compliance. For non-clinical inquiries, most respondents (60%) thought that it was easier to write electronic messages than communicate by phone. For clinical enquiries, many patients agreed that e-consultation could lead to a better followup (72%) and improved quality of treatment (58%). Users were highly satisfied with the services and recommended their use to others. Time saving was the most evident benefit for patients. This was confirmed by the differences in time spent using the digital health services compared with conventional approaches, all found to be statistically significant.ConclusionCitizens using e-consultation and other digital health services with their GP in Norway are satisfied and consider them as useful and efficient alternatives to conventional approaches.
How, why, for whom and in what context, do sexual health clinics provide an environment for safe and supported disclosure of sexual violence: protocol for a realist review
Authors: Caswell Rachel J , Maidment Ian , Ross Jonathan D C , Bradbury-Jones C 
Published: June 2020

IntroductionSupporting people subjected to sexual violence includes provision of sexual and reproductive healthcare. There is a need to ensure an environment for safe and supported disclosure of sexual violence in these clinical settings. The purpose of this research is to gain a deeper understanding of how, why, for whom and in what circumstances safe and supported disclosure occurs in sexual health services.Methods and analysisTo understand how safe and supported disclosure of sexual violence works within sexual health services a realist review will be undertaken with the following steps: (1) Focussing of the review including a scoping literature search and guidance from an advisory group. (2) Developing the initial programme theories and a search strategy using context-mechanism-outcome (CMO) configurations. (3) Selection, data extraction and appraisal based on relevance and rigour. (4) Data analysis and synthesis to further develop and refine programme theory, CMO configurations with consideration of middle-range and substantive theories.Data analysisA realist logic of analysis will be used to align data from each phase of the review, with CMO configurations being developed. Programme theories will be sought from the review that can be further tested in the field.Ethics and disseminationThis study has been approved by the ethics committee at University of Birmingham, and has Health Research Authority approval. Findings will be disseminated through knowledge exchange with stakeholders, publications in peer-reviewed journals, conference presentations and formal and informal reports. In addition, as part of a doctoral study, the findings will be tested in multisite case studies.PROSPERO registration detailsCRD4201912998. Dates of the planned realist review, from protocol design to completion, January 2019 to July 2020.