bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a novel LPL nonsense variant and further insights into the complex etiology and expression of hypertriglyceridemia-induced acute pancreatitis
Authors: Li Xiao-Yao , Pu Na , Chen Wei-Wei , Shi Xiao-Lei , Zhang Guo-fu , Ke Lu , Ye Bo , Tong Zhi-Hui , Wang Yu-Hui , Liu George , Chen Jian-Min , Yang Qi , Li Wei-Qin , Li Jie-Shou 
Published: April 2020

Abstract
Background
Hypertriglyceridemia (HTG) is a leading cause of acute pancreatitis. HTG can be caused by either primary (genetic) or secondary etiological factors, and there is increasing appreciation of the interplay between the two kinds of factors in causing severe HTG.

Objectives
The main aim of this study was to identify the genetic basis of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) in a Chinese family with three affected members (the proband, his mother and older sister).

Methods
The entire coding and flanking sequences of LPL, APOC2, APOA5, GPIHBP1 and LMF1 genes were analyzed by Sanger sequencing. The newly identified LPL nonsense variant was subjected to functional analysis by means of transfection into HEK-293 T cells followed by Western blot and activity assays. Previously reported pathogenic LPL nonsense variants were collated and compared with respect to genotype and phenotype relationship.

Results
We identified a novel nonsense variant, p.Gln118* (c.351C > T), in the LPL gene, which co-segregated with HTG-AP in the Chinese family. We provided in vitro evidence that this variant resulted in a complete functional loss of the affected LPL allele. We highlighted a role of alcohol abuse in modifying the clinical expression of the disease in the proband. Additionally, our survey of 12 previously reported pathogenic LPL nonsense variants (in 20 carriers) revealed that neither serum triglyceride levels nor occurrence of HTG-AP was distinguishable among the three carrier groups, namely, simple homozygotes, compound heterozygotes and simple heterozygotes.

Conclusions
Our findings, taken together, generated new insights into the complex etiology and expression of HTG-AP.
A multidimensional systems biology analysis of cellular senescence in aging and disease
Authors: Avelar Roberto A. , Ortega Javier Gómez , Tacutu Robi , Tyler Eleanor J. , Bennett Dominic , Binetti Paolo , Budovsky Arie , Chatsirisupachai Kasit , Johnson Emily , Murray Alex , Shields Samuel , Tejada-Martinez Daniela , Thornton Daniel , Fraifeld Vadim E. , Bishop Cleo L. , de Magalhães João Pedro 
Published: April 2020

Abstract
Background
Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many genes play a role in cellular senescence, yet a comprehensive understanding of its pathways is still lacking.

Results
We develop CellAge (http://genomics.senescence.info/cells), a manually curated database of 279 human genes driving cellular senescence, and perform various integrative analyses. Genes inducing cellular senescence tend to be overexpressed with age in human tissues and are significantly overrepresented in anti-longevity and tumor-suppressor genes, while genes inhibiting cellular senescence overlap with pro-longevity and oncogenes. Furthermore, cellular senescence genes are strongly conserved in mammals but not in invertebrates. We also build cellular senescence protein-protein interaction and co-expression networks. Clusters in the networks are enriched for cell cycle and immunological processes. Network topological parameters also reveal novel potential cellular senescence regulators. Using siRNAs, we observe that all 26 candidates tested induce at least one marker of senescence with 13 genes (C9orf40, CDC25A, CDCA4, CKAP2, GTF3C4, HAUS4, IMMT, MCM7, MTHFD2, MYBL2, NEK2, NIPA2, and TCEB3) decreasing cell number, activating p16/p21, and undergoing morphological changes that resemble cellular senescence.

Conclusions
Overall, our work provides a benchmark resource for researchers to study cellular senescence, and our systems biology analyses reveal new insights and gene regulators of cellular senescence.
Fighting against the common enemy of COVID-19: a practice of building a community with a shared future for mankind
Authors:   Members of Steering Committee, Society of Global Health, Chinese Preventive Medicine Association, Qian Xu , Ren Ran , Wang Youfa , Guo Yan , Fang Jing , Wu Zhong-Dao , Liu Pei-Long , Han Tie-Ru 
Published: April 2020

AbstractThe outbreak of coronavirus disease 2019 (COVID-19) has caused more than 80 813 confirmed cases in all provinces of China, and 21 110 cases reported in 93 countries of six continents as of 7 March 2020 since middle December 2019. Due to biological nature of the novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with faster spreading and unknown transmission pattern, it makes us in a difficulty position to contain the disease transmission globally. To date, we have found it is one of the greatest challenges to human beings in fighting against COVID-19 in the history, because SARS-CoV-2 is different from SARS-CoV and MERS-CoV in terms of biological features and transmissibility, and also found the containment strategies including the non-pharmaceutical public health measures implemented in China are effective and successful. In order to prevent a potential pandemic-level outbreak of COVID-19, we, as a community of shared future for mankind, recommend for all international leaders to support preparedness in low and middle income countries especially, take strong global interventions by using old approaches or new tools, mobilize global resources to equip hospital facilities and supplies to protect noisome infections and to provide personal protective tools such as facemask to general population, and quickly initiate research projects on drug and vaccine development. We also recommend for the international community to develop better coordination, cooperation, and strong solidarity in the joint efforts of fighting against COVID-19 spreading recommended by the joint mission report of the WHO-China experts, against violating the International Health Regulation (WHO, 2005), and against stigmatization, in order to eventually win the battle against our common enemy — COVID-19.
Protein tyrosine phosphatase 1B is involved in efficient type I interferon secretion upon viral infection
Authors: Reimer Elisa , Stempel Markus , Chan Baca , Bley Hanna , Brinkmann Melanie M. 
Published: April 2020

ABSTRACT
Protein tyrosine phosphatase 1B (PTP1B, also known as PTPN1) is a negative regulator of the leptin and insulin signalling pathways. This phosphatase is of great interest as PTP1B-knockout mice are protected against the development of obesity and diabetes. Here, we provide evidence for a novel function of PTP1B that is independent of its phosphatase activity, but requires its localisation to the membrane of the endoplasmic reticulum. Upon activation of pattern recognition receptors, macrophages and plasmacytoid dendritic cells from PTP1B-knockout mice secrete lower amounts of type I interferon (IFN) than cells from wild-type mice. In contrast, secretion of the proinflammatory cytokines TNFα and IL6 was unaltered. While PTP1B deficiency did not affect Ifnb1 transcription, type I IFN accumulated in macrophages, suggesting a role for PTP1B in mediating secretion of type I IFN. In summary, we have uncovered that PTP1B positively regulates the type I IFN response by promoting secretion of key antiviral cytokines.
Aspects of Moral Education of Students Through the Prism of Christian Values
Authors: Nesova N. 
Published: April 2020

The issue of spiritual and moral education of student youth is very relevant for modern science and practice. The article substantiates the need for spiritual and moral education of the young generation on Christian values. The accumulated experience in introducing the value foundations of Christianity in the system of work of a higher educational institution is highlighted.
The purpose of the study is to establish the psychological patterns and mechanisms of spiritual and moral education of the student’s personality through the initiation and adoption of Christian values. Achieving the goal of the study involved solving the following issues: to carry out a psychological theoretical and methodological analysis of the problem of spiritual and moral education of a person; offer a system of psychological and pedagogical exercises aimed at promoting the spiritual and moral education of the student’s personality; to develop and test a training program for the spiritual formation of the student’s personality.
The author proposed mechanisms for the formation of spiritual values of the student’s personality, developed psychological training for the formation of the spirituality of the student’s personality.
A Glut Of Faces
Authors: Fiedrich Kristina 
Published: April 2020

Abstract
The face is a bodily surface that visually, historically and politically locates identity. Under the scrutiny of facial recognition and biometric software, the face can take the place of a whole identity, becoming a rigid singular representation. This paper draws connections between the increasing trends in surveillance and biometric technologies, and their manifestation within contemporary art practices. Specifically, I look to artworks that engage traditional portraiture and representations of the face, all the while manipulating expectations of the face-as-portrait. Artworks included in this project are Ursula Johnson’s L’nuweltik (We are Indian), Gillian Wearing’s Self Portrait at Twenty Seven Years Old and Anthony Cerniello’s Danielle. How has the face come to be represented in contemporary portraiture, and might these representations suggest a shifting logic of identity, away from the face? Art as visual expression is considered in relation to surveillance as another outcome of visual culture that highlights a continuing desire to categorize the subject within a social order.
Game-Based Promotion of Motivation and Attention for Socio-Emotional Training in Autism
Authors: Strickroth Sven , Zoerner Dietmar , Moebert Tobias , Morgiel Anna , Lucke Ulrike 
Published: April 2020

Abstract
Caused by a deviance of their reward system, autistic people show attention deficits for learning content outside their special fields of interest. This can lead to significant problems, especially in formal learning situations. A promising approach to increase attention is the use of game-based learning concepts. The effect of individual playful aspects could be shown in existing learning systems. However, these do not provide consistent game experiences, which may result in a decreasing motivation for training. Therefore, this paper presents requirements as well as a related game concept to integrate the learning content with a playful narrative in order to promote motivation and attention for socio-emotional training.
КРИТИЧНИЙ ДИСКУРС АНАЛІЗ: ЯК ЗАБЕЗПЕЧУВАТИ РЕПРЕЗЕНТАТИВНІСТЬ КОРПУСУ ТЕКСТІВ?
Authors: Кочубейник Ольга 
Published: April 2020

Нині в психології спостерігається тенденція до поширення зони застосування якісних методів дослідження, котрі звертаються до вивчення лінгвістичних репрезентацій соціальної реальності (нара­тивний аналіз, дискурсивний аналіз, конверсаційний аналіз та інші). Ці методи є, безсумнівно, ефек­тивним інструментом психологічних досліджень. Однак необхідним є чітке розуміння можливостей і обмежень використання цих методів. Статтю присвячено актуальній проблемі оцінювання репрезен­тативності корпусу текстів, що передбачає включення в нього необхідної і достатньої кількості текстів, яка забезпечить вирішення дослідницьких завдань. Поняття репрезентативності висвіт­люєть­ся під різними кутами зору, після чого робиться висновок, що особистість дослідника, який фор­мує корпус текстів, значною мірою впливає на його репрезентативність. Автор наголошує на немож­ливості складання корпусу текстів, вивільненого від настановлень дослідника, що його формував, і вказує на недоліки застосовуваних тактик контролю такого впливу. На основі теоретичного аналізу розкрито роль міждослідницької тріангуляції в забезпеченні репрезентативності корпусу текстів та підвищенні валідності результатів емпіричного дослідження. Авторка підкреслює, що міждослідницька тріангуляція дає можливість сформулювати концептуальні узагальнення на базі результатів, отри­маних різними експертами. Застосування такої тріангуляції як дослідницької тактики, необхідної для формування корпусу текстів, відповідає загальним вимогам якісних досліджень. Наприкінці авторка формулює питання, які потребують подальшого дослідження в зазначеному напрямку.
После Крыма: исчезающий консенсус
Authors: Белоусов Александр Борисович 
Published: April 2020

Цитирование: Белоусов А.Б. (2020) После Крыма: исчезающий консенсус // Мир России. Т. 29. № 2. С. 195–204. DOI: 10.17323/1811-038X-2020-29-2-195-204
Коллективная монография «Выборы на фоне Крыма» вышла в очень удобный для осмысления момент: выборный цикл 2016–2018 годов закончился, а вместе с ним – и патриотический подъем; следующий цикл эпохи транзита начинается на наших глазах. Можно открыть книгу на любой странице и, читая оценки политологов и социологов, время от  времени восклицать «сегодня это не так!» или «а ведь совсем недавно так оно и было!», и для этого будут все основания. «Пересушенная» явка в сентябре 2016 года привела к тому, что протестная мобилизация стала концентрироваться на внеэлекторальных площадках, а административная мобилизация все чаще порождала голосование «с фигой в кармане». Попытка ограничить политическую субъектность города с помощью лепестковой нарезки оказалась не способна повлиять на повышенный интерес протестных лидеров к городской проблематике. Крымский консенсус позволил «Единой России» набрать довольно большой процент на  выборах в Государственную Думу 2016 года, однако не смог предотвратить делигитимацию партии власти, резко усилившуюся после пенсионной реформы; в дальнейшем провалились попытки замаскировать провластных кандидатов с помощью процедур самовыдвижения. Вместо снижения уровня партийной конкурентности Россия получила на выборах 2019 года первый опыт успешной коалиционной сделки. Помимо этого, зачистка политического пространства породила безлидерский протест, а постоянная мобилизация административного электората начала вымывать из процедуры выборов смысловую составляющую. Монография «Выборы на фоне Крыма» дает прекрасную возможность почувствовать, как время ускоряется прямо на наших глазах, и станет лучшим ответом скептикам, которые полагают, что мы живем в стране, где ничего не меняется. Помимо исторической, у книги «Выборы на фоне Крыма» немало других достоинств: она указывает на  точку, с помощью которой намного легче понять, в каком направлении и насколько далеко мы ушли от патриотического подъема 2014 года.
QUERY ANSWERING SYSTEM OF SHAHIH HADITH MUTTAFAQUN ‘ALAIH USING INDONESIAN THESAURUS BASED ON QUERY EXPANSION AND NAÏVE BAYES CLASSIFIER
Authors: Rounaqi Muhammad Fairuz Zumar 
Published: April 2020

<p class="Text"><em><span style="font-size: 9.0pt; line-height: 105%;">Abstract</span></em><span style="font-size: 9.0pt; line-height: 105%;">— Hadith are all the words, deeds and provisions of the Prophet Muhammad SAW that are used as the second of Islamic law after Al-Quran. The purpose of this study is to make an Information Retrieval system called the Query Answering System is expected to facilitate users in searching and finding the hadith documents as the user's needs. This study implements the Naïve Bayes Classifier method combined with Indonesian thesaurus as a query expansion to find the hadith documents that relevant to the input query. Based on the testing of 50 query data, the test results show that the use of query expansion gives better results than without using query expansion. Where based on testing of the top 1 data without using query expansion obtained an average recall value of 62%, an average precision value of 62%, an average accuracy value of 92.4% and an average value of the f-measure of 62%, while testing using query expansion obtained an average recall value of 66%, an average precision value of 66%, an average accuracy value of 93.2% and an average f -measure value of 66%. Based on the test results, the use of query expansion shows an improvement in the average recall value of 4%, an improvement in the average precision value of 4%, and an improvement in the average accuracy value of 0.8% and an improvement in the average f-measure value of 4% compared on without using query expansion.</span></p><p class="MsoNormal"> </p><p class="IndexTerms"><em>Index Terms</em>—hadith, information retrieval, query expansion, naïve bayes. </p>
Indonesia in the South China Sea: Foreign Policy and Regional Order
Authors: Wicaksana I Gede Wahyu 
Published: April 2020

This paper looks at how Indonesia contributes to the creation of a relatively peaceful and stable Southeast Asian region after the Cold War. It examines Jakarta’s diplomacy in the South China Sea, and explains its implications for the making of the regional order. The argument is that Indonesia’s impact on regional security has been apparent in its attention to the improvement of rule-based interaction among states in the region. However, recent developments have demonstrated that Indonesia’s initiatives, formulated in the Indo-Pacific Cooperation Concept, are unsuccessful due to the lack of support from other ASEAN states. This paper shows that great powers politics in the troubled waters has hindered the advancement of Indonesian’s order-driven policy. Keywords: ASEAN, Indonesia, Indo-Pacific Concept, Regional Order, South China Sea. Tulisan ini membahas kontribusi Indonesia dalam menciptakan Kawasan Asia Tenggara yang relatif damai dan stabil setelah Perang Dingin berakhir. Fokus bahasan pada diplomasi yang dilakukan dalam meresolusi konflik Laut China Selatan. Penulis berargumen dampak keterlibatan Indonesia terlihat dari upaya untuk mendorong interaksi yang berdasarkan pada norma dan aturan bersama antar-negara Asia Tetangga. Namun, perkembangan terkini menunjukkan inisiatif Jakarta, khususnya Konsep Kerja Sama Indo-Pasifik, kurang berhasil karena kurang mendapat dukungan anggota ASEAN. Paper ini juga membuktikan bahwa politik kekuatan menjadi hambatan bagi implementasi kebijakan luar negeri Indonesia dalam kasus Laut China Selatan. Kata-kata kunci: ASEAN, Indonesia, Indo-Pasifik, Laut China Selatan, Tatanan Kawasan.
Survey of COVID-19 Disease Among Orthopaedic Surgeons in Wuhan, People’s Republic of China
Authors: Guo Xiaodong , Wang Jiedong , Hu Dong , Wu Lisha , Gu Li , Wang Yang , Zhao Jingjing , Zeng Lian , Zhang Jianduan , Wu Yongchao 
Published: April 2020

Background:
Coronavirus disease 2019 (COVID-19) broke out in Wuhan, the People’s Republic of China, in December 2019 and now is a pandemic all around the world. Some orthopaedic surgeons in Wuhan were infected with COVID-19.

Methods:
We conducted a survey to identify the orthopaedic surgeons who were infected with COVID-19 in Wuhan. A self-administered questionnaire was distributed to collect information such as social demographic variables, clinical manifestations, exposure history, awareness of the outbreak, infection control training provided by hospitals, and individual protection practices. To further explore the possible risk factors at the individual level, a 1:2 matched case-control study was conducted.

Results:
A total of 26 orthopaedic surgeons from 8 hospitals in Wuhan were identified as having COVID-19. The incidence in each hospital varied from 1.5% to 20.7%. The onset of symptoms was from January 13 to February 5, 2020, and peaked on January 23, 8 days prior to the peak of the public epidemic. The suspected sites of exposure were general wards (79.2%), public places at the hospital (20.8%), operating rooms (12.5%), the intensive care unit (4.2%), and the outpatient clinic (4.2%). There was transmission from these doctors to others in 25% of cases, including to family members (20.8%), to colleagues (4.2%), to patients (4.2%), and to friends (4.2%). Participation in real-time training on prevention measures was found to have a protective effect against COVID-19 (odds ratio [OR], 0.12). Not wearing an N95 respirator was found to be a risk factor (OR, 5.20 [95% confidence interval (CI), 1.09 to 25.00]). Wearing respirators or masks all of the time was found to be protective (OR, 0.15). Severe fatigue was found to be a risk factor (OR, 4 [95% CI, 1 to 16]) for infection with COVID-19.

Conclusions:
Orthopaedic surgeons are at risk during the COVID-19 pandemic. Common places of work could be contaminated. Orthopaedic surgeons have to be more vigilant and take more precautions to avoid infection with COVID-19.

Level of Evidence:
Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
A study of working conditions in the heat-treating workshops
Authors: Lazarenkov A. M. 
Published: April 2020

The results of the study of working conditions in heat-treating workshops are presented. It is shown that the main production factors of working conditions are noise, vibration, dust, gas, air temperature, the intensity of infrared (thermal) radiation, the severity and intensity of the labor process.The results of the conducted research have shown that all workplaces have exceeded the permissible values for noise, the content of harmful substances in the air of the working environment, the intensity of infrared (thermal) radiation and the air temperature. It is noted that the work performed due to the severity and intensity of the labor process can negatively affect the health of employees.
Checking the sensitivity and accuracy of humidity indicators
Authors: Trukhanovich T. Yu. 
Published: April 2020

Discusses the problems of protecting the goods during transport from exposure to high humidity and ways of its solutions; the presence of some consumers ‘ requirements for adherence to the maximum values of humidity and confirmation of its actual value in the packed products; the use of paper humidity indicators to control the environment during transit; the principle of operation of the indicator based on the change in color of cobalt salts depending on the composition of the crystalline.There is a lack of methodology for quality control of paper humidity indicators. The method developed by the laboratory of OJSC «BSW» – Management Company of the Holding «BMC», to determine their sensitivity and accuracy is given. The essence of the test is to assemble an installation that provides a certain value of air humidity. To do this, we use solutions of sulfuric acid of the appropriate concentrations. Air is passed first through water, then through solutions and fed into a flask with an indicator. Depending on the humidity of the supplied air, the corresponding indicator points change colour. Sensitivity and accuracy are evaluated on a colour scale.