bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research advances on neurite outgrowth inhibitor B receptor
Authors: Zhang Rui , Tang Bei‐sha , Guo Ji‐feng 
Published: June 2020

AbstractNeurite outgrowth inhibitor‐B (Nogo‐B) is a membrane protein which is extensively expressed in multiple organs, especially in endothelial cells and vascular smooth muscle cells of blood vessels and belongs to the reticulon protein family. Notably, its specific receptor, Nogo‐B receptor (NgBR), encoded by NUS1, has been implicated in many crucial cellular processes, such as cholesterol trafficking, lipid metabolism, dolichol synthesis, protein N‐glycosylation, vascular remodelling, angiogenesis, tumorigenesis and neurodevelopment. In recent years, accumulating studies have demonstrated the statistically significant changes of NgBR expression levels in human diseases, including Niemann‐Pick type C disease, fatty liver, congenital disorders of glycosylation, persistent pulmonary hypertension of the newborn, invasive ductal breast carcinoma, malignant melanoma, non‐small cell lung carcinoma, paediatric epilepsy and Parkinson's disease. Besides, both the in vitro and in vivo studies have shown that NgBR overexpression or knockdown contribute to the alteration of various pathophysiological processes. Thus, there is a broad development potential in therapeutic strategies by modifying the expression levels of NgBR.
Use and abuse of regulated prices in electricity markets: “How to regulate regulated prices?”
Authors: Martimort David , Pouyet Jérôme , Staropoli Carine 
Published: June 2020

AbstractWe consider the regulation of the tariffs charged by a public utility in the electricity sector. Consumers differ in terms of their privately known demands. When regulating a firm's tariffs, the government is concerned by the redistribution across consumer classes. A conflict between redistribution and screening induces pricing distortions when the firm is a monopoly. Introducing competition with an unregulated fringe improves efficiency but jeopardizes redistribution. In response to this problem, the government may now want to manipulate information about the incumbent's cost to restrict entry and better promote its own redistributive objective. To prevent such obstacle to entry, the government's discretion in fixing the incumbent's regulated tariffs should be restricted by imposing floors or caps on those tariffs and/or by controlling the market share left to the competitive fringe. We highlight the determinants of such limits on discretion and unveil to what extent they depend on the government's redistributive concerns.
Sustainability assessment of a novel micro solar thermal: Biomass heat and power plant in Morocco
Authors: Herrera Israel , Rodríguez‐Serrano Irene , Garrain Daniel , Lechón Yolanda , Oliveira Armando 
Published: June 2020

AbstractNovel renewable energy technologies in the Middle East and North Africa region can be developed through microgeneration systems aiming to supply local energy demands in a sustainable way. In this study, we carried out a sustainability assessment combining two reputable methodologies which have been applied to a facility comprising a hybrid solar/biomass micro‐cogeneration organic ranking cycle system located in Morocco. We first applied a multiregional input–output analysis where economic issues such as the production of goods and services generated in all project's phases, as well as the added value and employment created, are estimated. Then, environmental impacts were assessed through a life cycle assessment (LCA). In terms of socioeconomic analysis, the total production of goods and services shows a value of 1.18 €2015/kWh. The added value and employment creation were 0.56 €2015/kWh and 0.05 full‐time employees/MWh, respectively. The levelized cost of electricity results in 0.218 €2015/kWh and the multiplier effect amounts to 2.26. The largest increase in sectorial output is produced in the Moroccan electricity sector and the largest job creation takes place in the agriculture sector from the biomass supply. Regarding environmental results, LCA shows a climate change potential of 11.8 g CO2eq/kWhel, of which more than 70% comes from the boiler operation and specifically from the emissions due to biomass transportation. These results can help in promoting micro solar‐biomass systems in Morocco as they identify the socioeconomic and environmental benefits that can counterbalance the higher costs of such systems compared to fossil technologies.
Community Susceptibility and Resiliency to COVID‐19 Across the Rural‐Urban Continuum in the United States
Authors: Peters David J. 
Published: June 2020

AbstractPurposeThis study creates a COVID‐19 susceptibility scale at the county level, describes its components, and then assesses the health and socioeconomic resiliency of susceptible places across the rural‐urban continuum.MethodsFactor analysis grouped 11 indicators into 7 distinct susceptibility factors for 3,079 counties in the conterminous United States. Unconditional mean differences are assessed using a multivariate general linear model. Data from 2018 are primarily taken from the US Census Bureau and CDC.ResultsAbout 33% of rural counties are highly susceptible to COVID‐19, driven by older and health‐compromised populations, and care facilities for the elderly. Major vulnerabilities in rural counties include fewer physicians, lack of mental health services, higher disability, and more uninsured. Poor Internet access limits telemedicine. Lack of social capital and social services may hinder local pandemic recovery. Meat processing facilities drive risk in micropolitan counties. Although metropolitan counties are less susceptible due to healthier and younger populations, about 6% are at risk due to community spread from dense populations. Metropolitan vulnerabilities include minorities at higher health and diabetes risk, language barriers, being a transportation hub that helps spread infection, and acute housing distress.ConclusionsThere is an immediate need to know specific types of susceptibilities and vulnerabilities ahead of time to allow local and state health officials to plan and allocate resources accordingly. In rural areas it is essential to shelter‐in‐place vulnerable populations, whereas in large metropolitan areas general closure orders are needed to stop community spread. Pandemic response plans should address vulnerabilities.
Decline in prevalence of congenital sensorineural deafness in Dalmatian dogs in the United Kingdom
Authors: Lewis Tom , Freeman Julia , De Risio Luisa 
Published: June 2020

AbstractBackgroundCongenital sensorineural deafness (CSD) is the most common type of deafness in Dalmatian dogs.ObjectivesTo use results of CSD screening in Dalmatian dogs in the United Kingdom in genetic analysis and to determine any changes in the prevalence of CSD in this breed over time.AnimalsA total of 8955 Dalmatian puppies undergoing hearing function screening using brainstem auditory evoked response (BAER) between July 1992 and February 2019.MethodsResults of BAER testing and pigmentation phenotypic data were linked to the UK Kennel Club Dalmatian pedigree database. Mixed model analysis was used to estimate variance parameters.ResultsThe overall prevalence of CSD was 17.8% (13.4%, unilateral; 4.4%, bilateral). Heritability of CSD was approximately 0.3 (across models) and significantly >0. Genetic correlations between CSD and blue irises (+0.6) and pigmented head patch (−0.86) were large in magnitude and significantly different form 0. Significant improving phenotypic and genetic trends were identified, likely as the result of selection against deafness, equivalent to avoiding breeding with the 4% to 5% of animals with the highest genetic risk of CSD.Conclusions and Clinical ImportanceA decrease in the prevalence and genetic risk of CSD implies breeders have been selecting for hearing dogs. Selective breeding based on estimated breeding values (EBVs) can help further decrease the prevalence of CSD in Dalmatians in the future.
Pharmacokinetics and bioavailability of tildipirosin in rabbits following single‐dose intravenous and intramuscular administration
Authors: Xiong Jincheng , Xu Yuliang , He Shuang , Zhang Yanfang , Wang Zile , Wang Sihan , Jiang Haiyang 
Published: June 2020

AbstractThe objective of this study was to determine the pharmacokinetics of tildipirosin in rabbits after a single intravenous (i.v.) and intramuscular (i.m.) injection at a dose of 4 mg/kg. Twelve white New Zealand rabbits were assigned to a randomized, parallel trial design. Blood samples were collected prior to administration and up to 14 days postadministration. Plasma concentrations of tildipirosin were quantified using a validated ultra‐high‐performance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) method. The pharmacokinetic parameters were calculated using a noncompartmental model in WinNonlin 5.2 software. Following i.v. and i.m. administration, the elimination half‐life (T1/2λ) was 81.17 ± 9.28 and 96.68 ± 15.37 hr, respectively, and the mean residence time (MRTlast) was 65.44 ± 10.89 and 67.06 ± 10.49 hr, respectively. After i.v. injection, the plasma clearance rate (Cl) and volume of distribution at steady state (Vdss) were 0.28 ± 0.10 L kg‐1 h−1 and 17.78 ± 5.15 L/kg, respectively. The maximum plasma concentration (Cmax) and time to reach maximum plasma concentration (Tmax) after i.m. administration were 836.2 ± 117.9 ng/ml and 0.33 ± 0.17 hr, respectively. The absolute bioavailability of i.m. administration was 105.4%. Tildipirosin shows favorable pharmacokinetic characteristics in rabbits, with fast absorption, extensive distribution, and high bioavailability. These findings suggest that tildipirosin might be a potential drug for the prevention and treatment of respiratory diseases in rabbits.
Help‐seekers, Callers and Clients: Embodied History in China's psy‐boom
Authors: Bram Barclay 
Published: June 2020

AbstractMs. Zhou, Ms. Liu, and Ms. Wen represent three generations of psychological counselors in China. They all work in Chengdu, the provincial capital of Sichuan province. China is in the midst of what scholars call the “psy‐boom.” This is generally defined as the rapid rise in psychological services in the country. Rather than understanding this rise as a linear phenomenon or one in which the understanding of psychology and its uses are universally shared by all practitioners, these three therapists show how haphazard and staggered the uptake in psychological services has been. They also show how the different historical contexts and shifting qualification standards that defined their generation of the psy‐boom in turn shaped their therapeutic practice. The study uses Bourdieu's concept of the habitus to show how the embodied history of China's psy‐boom impacts the practice of counselling and understanding of psychology.
Beyond DNA barcoding: The unrealized potential of genome skim data in sample identification
Authors: Bohmann Kristine , Mirarab Siavash , Bafna Vineet , Gilbert M. Thomas P. 
Published: June 2020

AbstractGenetic tools are increasingly used to identify and discriminate between species. One key transition in this process was the recognition of the potential of the ca 658bp fragment of the organelle cytochrome c oxidase I (COI) as a barcode region, which revolutionized animal bioidentification and lead, among others, to the instigation of the Barcode of Life Database (BOLD), containing currently barcodes from >7.9 million specimens. Following this discovery, suggestions for other organellar regions and markers, and the primers with which to amplify them, have been continuously proposed. Most recently, the field has taken the leap from PCR‐based generation of DNA references into shotgun sequencing‐based “genome skimming” alternatives, with the ultimate goal of assembling organellar reference genomes. Unfortunately, in genome skimming approaches, much of the nuclear genome (as much as 99% of the sequence data) is discarded, which is not only wasteful, but can also limit the power of discrimination at, or below, the species level. Here, we advocate that the full shotgun sequence data can be used to assign an identity (that we term for convenience its “DNA‐mark”) for both voucher and query samples, without requiring any computationally intensive pretreatment (e.g. assembly) of reads. We argue that if reference databases are populated with such “DNA‐marks,” it will enable future DNA‐based taxonomic identification to complement, or even replace PCR of barcodes with genome skimming, and we discuss how such methodology ultimately could enable identification to population, or even individual, level.
Clinical and laboratory features of female Gitelman syndrome and the pregnancy outcomes in a Chinese cohort
Authors: Zhang Lei , Peng Xiaoyan , Zhao Bingbin , Zhu Zhifeng , Wang Ying , Tian Dongli , Yan Zhaoli , Yao Li , Liu Juntao , Qiu Ling , Xing Xiaoping , Chen Limeng 
Published: June 2020

AbstractAimGitelman syndrome (GS) is a rare inherited salt‐losing renal tubulopathy. Data on clinical features and the pregnancy outcome for female GS patients in a large cohort are lacking. The study was aimed to explore the phenotype and pregnant issue for female GS patients.MethodsGS cases from the National Rare Diseases Registry System of China (NRSC) were collected, and detailed clinical, laboratory and genetic data were analysed. Articles on pregnancy in GS were also systemically reviewed.ResultsA total of 101 GS patients were included; among them, 42.6% were female and 79.2% showed hypomagnesaemia. A lower proportion of female patients presented before 18 years of age, with less frequently reported polyuria, higher serum potassium and less urine sodium and chloride excretions. There was no gender difference in the sodium‐chloride cotransporter (NCC) dysfunction evaluated by hydrochlorothiazide test. Twelve of the 43 female GS patients delivered after disease symptom onset, and their pregnancies were generally uneventful. As a group, pregnant GS patients had lower potassium levels in the first‐trimester (P = .002) requiring higher potassium supplementation. After delivery, serum potassium (P = .02) and magnesium (P = .03) increased significantly. Both caesarean section and vaginal delivery were safe.ConclusionFemale GS patients may have a less severe phenotype with generally favourable outcomes of pregnancy. Intensive monitoring and increased potassium supplementation are necessary during pregnancy, especially in the first‐trimester.
Nasolabial fold dynamics: Implications for facial paralysis and facial reanimation surgery
Authors: Dusseldorp Joseph R. , Faraway Julian , Razavi Lily , Hadlock Tessa A. , Trotman Carroll Ann 
Published: June 2020

AbstractObjectivesIn patients with facial paralysis, facial reanimation surgery may be needed to normalize facial soft tissue function/movements. Critical for this normalization is the dynamics of the nasolabial folds (NLFs). The objective of this prospective, observational study was to determine the 3D morphologic dynamics of the NLFs in patients with unilateral facial palsy and normal subjects.Settings and Sample Population3D facial soft tissue movement data collected from adults with unilateral, facial paralysis (Bell's Palsy, n = 36); and (2) an age‐ and sex‐frequency matched control group (n = 68).Materials and methodsMovement data were collected during repeated animations from participants using a video‐based motion capture system. Movement in terms of displacement and asymmetry of the NLFs, nasal and circumoral regions were analyzed in the lateral, vertical and depth planes; as well as movement of the commissure and NLFs relative to the lower lip midline. Two‐sample t tests were used to test for significant group differences.ResultsPatients NLFs had less mean displacement, greater mean asymmetry and uncoordinated movements compared with the controls. For both groups during smiling, the NLF and commissure landmarks had approximately similar magnitudes of displacement (control range = 11‐14mm; patient range = 7‐10mm).ConclusionNLF dynamics during smiling were as significant as oral commissure excursion. Thus, an immobile NLF is an unnatural feature of facial animations. Surgical treatments that address impaired NFL movements must be considered to create a more natural surgical outcome especially during smiling.
Low prevalence of arrhythmias in clinically stable COVID‐19 patients
Authors: Sala Simone , Peretto Giovanni , De Luca Giacomo , Farina Nicola , Campochiaro Corrado , Tresoldi Moreno , Dagna Lorenzo , Zangrillo Alberto , Gulletta Simone , Della Bella Paolo 
Published: June 2020

AbstractBackgroundNo studies investigated the prevalence of arrhythmias among clinically‐stable patients affected by COVID‐19 infection.MethodsWe assessed prevalence, type, and burden of arrhythmias, by a single‐day snapshot in seven non‐intensive COVID Units at a third‐level center.ResultsWe enrolled 132 inhospital patients (mean age 65±14y; 66% males) newly diagnosed with COVID‐19 infection. Arrhythmic episodes were detected in 12 patients (9%). In detail, 8 had atrial fibrillation, and 4 self‐limiting supraventricular tachyarrhythmias. There were no cases of ventricular arrhythmias or new‐onset atrioventricular blocks. In addition, we report no patients with QTc interval >450 ms.ConclusionsOur single‐day snapshot survey suggests that the prevalence of arrhythmias among clinically stable COVID‐19 patients is low. In particular, no life‐threatening arrhythmic events occurred.
Surgical and endoscopic management of a pericardioesophageal fistula after radiofrequency pulmonary vein isolation
Authors: Siroky Gregory P. , Niazi Kareem , Ghaly Aziz , Kahaleh Michel , Tyberg Amy , Langenfeld John , Kostis William J. , Kassotis John , Coromilas James , Saluja Deepak 
Published: June 2020

AbstractIntroductionThe most feared complication of pulmonary vein isolation (PVI) is an atrioesophageal fistula (AEF). While rare (0.1‐0.25%), primary surgical closure (as opposed to esophageal stenting) is associated with lower mortality. Pericardioesophageal fistula (PEF) may present prior to fistulization into the atrium. Unfortunately, data on the optimal management of PEFs are lacking.Case reportSeventy‐one‐year‐old male with AF presented with chest pain 3 weeks after radiofrequency PVI. Computed tomography angiography (CTA) chest and echocardiogram showed pneumopericardium. Barium esophagram showed extravasation from esophagus into the pericardium without connection to the left atrium. Sternotomy with mediastinal exploration exposed the pericardial defect, over which a CorMatrix patch was placed. The fistula was then stented endoscopically with endosuture fixation. Poststent esophagram did not show barium leak, and the patient was discharged home. One week later, the patient returned with enterococcal and candida bacteremia and an acute right parietal/occipital lobe infarct. Barium esophagram showed contrast extravasation into the pericardium. The patient rapidly succumbed to his illness and died. Autopsy revealed pericardial abscess posterior to the LA in communication with the esophagus. Extension to the LA was not seen.ConclusionWhile the surgical treatment of AEF is relatively well established, there is no consensus in the management of PEF. While prior small series have suggested PEF may be managed with esophageal stenting, our case illustrates the limitations of this approach.
Longevity and Utilization Cost of Rechargeable and Non‐Rechargeable Spinal Cord Stimulation Implants: A Comparative Study
Authors: Costandi Shrif , Mekhail Nagy , Azer Gerges , Mehanny Diana Sue , Hanna Demiana , Salma Yustina , Bolash Robert , Saweris Youssef 
Published: June 2020

AbstractIntroductionDespite major advancements in features and capabilities of the implantable pulse generator (IPG), real‐life longevity and cost‐effectiveness studies to guide pain specialists to make the appropriate choice between rechargeable and non‐rechargeable IPG are limited. Our study aimed to compare the longevity and cost effectiveness of rechargeable vs. non‐rechargeable IPG and SCS systems.MethodsData were collected for all SCS implantations performed between 1994 and 2018. The primary goal was to determine IPG longevity, defined as the time interval between IPG implantation and elective replacement due to IPG end of life (EOL). On the other hand, SCS system longevity was defined as the time between SCS implantation and its removal or revision for any reason other than IPG EOL. Kaplan‐Meier and log‐rank tests were used to assess IPG and SCS system longevities. Cost analysis was performed for cost effectiveness.ResultsThe median IPG longevity was significantly higher for rechargeable SCS devices than for non‐rechargeable SCS devices (7.20 years and 3.68 years, respectively). The median cost per day was similar for both IPGs, $13.90 and $13.81 for non‐rechargeable and rechargeable, respectively. The median cost for SCS systems was higher for the rechargeable group ($60.70) compared with the non‐rechargeable group ($31.38).ConclusionsRechargeable IPG had increased longevity compared to their non‐rechargeable counterparts, yet there was no significant difference in the actual longevity due to premature revisions or explantations between both SCS systems. Furthermore, non‐rechargeable SCS systems were found to be the more cost‐effective option when compared with rechargeable SCS systems.
The acceptability, effectiveness, and durability of cognitive analytic therapy: Systematic review and meta‐analysis
Authors: Hallam Craig , Simmonds‐Buckley Melanie , Kellett Stephen , Greenhill Beth , Jones Andrew 
Published: June 2020

ObjectivesThis paper sought to conduct a meta‐analysis of the effectiveness and durability of cognitive analytic therapy (CAT) and assess the acceptability of CAT in terms of dropout rates.DesignSystematic review and meta‐analysis.MethodsPROSPERO registration: CRD42018086009. Searches identified CAT treatment outcome studies eligible to be narratively synthesized. Pre–post/post‐follow‐up effect sizes (ESs) were extracted and synthesized in a random‐effects meta‐analysis. Variations in effect sizes were explored using moderator analyses. Dropout rates were extracted. Secondary analyses synthesized between‐group ES from trials of CAT.ResultsTwenty‐five studies providing pre–post CAT treatment outcomes were aggregated across three outcome comparisons of functioning, depression, and interpersonal problems. CAT produced large pre–post improvements in global functioning (ES = 0.86; 95% CI 0.71–1.01, N = 628), moderate‐to‐large improvements in interpersonal problems (ES = 0.74, 95% CI 0.51–0.97, N = 460), and large reductions in depression symptoms (ES = 1.05, 95% CI 0.80–1.29, N = 586). All these effects were maintained or improved upon at follow‐up. Limited moderators of CAT treatment effect were identified. CAT demonstrated small–moderate, significant post‐treatment benefits compared to comparators in nine clinical trials (ES = 0.36–0.53; N = 352). The average dropout rate for CAT was 16% (range 0–33%).ConclusionsPatients with a range of presenting problems appear to experience durable improvements in their difficulties after undergoing CAT. Recommendations are provided to guide the further progression of the CAT outcome evidence base.Practitioner points

Large pre–post reductions in global functioning and depression outcomes and moderate–large reductions in interpersonal problems are evident after CAT.

The effects of CAT appear durable, and interpersonal functioning significantly improves over follow‐up time.

CAT produces small–moderate benefits compared to trial comparators.

CAT appears to be an engaging psychotherapy that maintains patients in treatment.