bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse
Authors: Zaki Yosif , Mau William , Cincotta Christine , Doucette Emily , Grella Stephanie L. , Merfeld Emily , Murawski Nathen J. , Shpokayte Monika , Ramirez Steve 
Published: December 2019

SummaryThe formation and extinction of fear memories represent two forms of learning that each engage the hippocampus and amygdala. How cell populations in these areas contribute to fear relapse, however, remains unclear. Here, we demonstrate that, in male mice, cells active during fear conditioning in the dentate gyrus of hippocampus exhibit decreased activity during extinction and are re-engaged after contextual fear relapse.In vivocalcium imaging reveals that relapse drives population dynamics in the basolateral amygdala to revert to a network state similar to the state present during fear conditioning. Finally, we find that optogenetic inactivation of neuronal ensembles active during fear conditioning in either the hippocampus or amygdala is sufficient to disrupt fear expression after relapse. These results suggest that fear relapse triggers a partial re-emergence of the original fear memory representation, providing new insight into the neural substrates of fear relapse.
Becoming a better parent: mice learn sounds that improve a stereotyped maternal behavior
Authors: Dunlap Alexander G. , Besosa Cristina , Pascual Leila M. , Chong Kelly K. , Walum Hasse , Kacsoh Dorottya B. , Tankeu Brenda B. , Lu Kai , Liu Robert C. 
Published: December 2019

AbstractWhile mothering is often instinctive and stereotyped in species-specific ways, evolution can favor genetically “open” behavior programs that allow experience to shape infant care. Among experience-dependent maternal behavioral mechanisms, sensory learning about infants has been hard to isolate from motivational changes arising from sensitization with infants. We developed a paradigm where sensory learning of an infant-associated cue improves a stereotypical maternal behavior in female mice. Mice instinctively employed a spatial memory-based strategy when engaged repetitively in a pup search and retrieval task. However, by playing a sound from a T-maze arm to signal where a pup will be delivered for retrieval, mice learned within 7 days and retained for at least 2 weeks the ability to use this specific cue to guide a more efficient search strategy. The motivation to retrieve pups also increased, but that alone did not sufficiently explain the shift in search strategy. Bilaterally silencing auditory cortical activity significantly impaired the new strategy without changing the motivation to retrieve pups. Finally, motherhood as compared to infant-care experience alone accelerated how quickly the new sensory-based strategy was acquired, suggesting a role for the maternal hormonal state. By rigorously establishing that newly formed sensory associations can improve the performance of a natural maternal behavior, this work facilitates future studies into the neurochemical and circuit mechanisms that mediate novel sensory learning in the maternal context, as well as more learning-based mechanisms of parental behavior in rodents.
14-3-3γ prevents centrosome duplication by inhibiting NPM1 function
Authors: Bose Arunabha , Modi Kruti , Dey Suchismita , Dalvi Somavally , Nadkarni Prafful , Sudarshan Mukund , Kundu Tapas Kumar , Venkatraman Prasanna , Dalal Sorab N. 
Published: December 2019

Abstract14-3-3 proteins bind to ligands via phospho-Serine containing consensus motifs. However, the molecular mechanisms underlying complex formation and dissociation between 14-3-3 proteins and their ligands remain unclear. We identified two conserved acidic residues in the 14-3-3 peptide-binding pocket (D129 and E136) that potentially regulate complex formation and dissociation. Altering these residues to Alanine led to opposing effects on centrosome duplication. D129A inhibited centrosome duplication while E136A stimulated centrosome amplification. These results were due to the differing abilities of these mutant proteins to form a complex with NPM1. Inhibiting complex formation between NPM1 and 14-3-3γ led to an increase in centrosome duplication and overrode the ability of D129A to inhibit centrosome duplication. We identify a novel role of 14-3-3 in regulating centrosome licensing and a novel mechanism underlying the formation and dissociation of 14-3-3 ligand complexes dictated by conserved residues in the 14-3-3 family.
Wheel design and motion analysis of a new heavy-duty AGV in aircraft assembly lines
Authors: Jiang Junxia , Zhang Shenglin , He Yuxiao 
Published: December 2019

Purpose
The flexible automatic transportation and manual assembly jobs for large aircraft components demand an automated guided vehicle (AGV) system with heavy-duty capacity and omnidirectional movability. This paper aims to propose a four driving-steering wheels-four supporting-steering wheels (4DSW-4SSW) layout plan to enhance the controllability and moving stability of AGV.

Design/methodology/approach
The anti-vibration structure of DS wheels and high-torque steering mechanism of SS wheels with tapered rolling bearings are rigorously designed to meet the functional requirements. Based on the specific wheel layout and vehicle dynamics, the rotational kinematic model as well as the straight and rotational dynamic models of AGV are established by the authors. To well verify the motion characteristics of wheels under heavy load in three motion states including straight motion, self-rotation and rotation around a certain point, the simulations in ADAMS and factory experiments have all been conducted.

Findings
Simulation results indicate that normal and friction forces of DS wheels and SS wheels are very stable except for some small oscillations, which are caused by non-center load distribution on AGV. Experimental results on driving speed of AGV have directly demonstrated that its positioning accuracy is enough for use in real aircraft assembly lines.

Practical implications
The designed AGV system has been applied to the final assembly line of a certain aircraft in Aviation Industry Corporation of China, Ltd, whose assembly efficiency and flexibility have been significantly improved.

Originality/value
A new layout plan of wheels for an omnidirectional heavy-duty AGV is proposed, which enhances the operating and moving capacity of AGV. A function of human-machine collaboration is also offered by the AGV for transporting large workpieces intelligently and economically in aerospace and other heavy industries.
Employees’ perceptions on the relationship between human resource management practices and employee turnover
Authors: Basnyat Sandeep , Clarence Lao Chi Sio 
Published: December 2019

PurposeThe purpose of this paper is to explore hotel employees’ views on how human resource management (HRM) practices influence their turnover intentions.Design/methodology/approachThe data for this empirical study were collected through in-depth semi-structured interviews with 15 employees who had experience of working in various hotels in Macau, China. The thematic analysis approach was carried out to analyze the interview data and interpret the findings.FindingsThe findings of this study demonstrate that although employee-oriented human resource policies and practices are favored, the way HR department handles and implement those policies are valued more by hotel employees. Furthermore, the retention of an organizational culture that helps create a feeling of ownership among employees is highly influenced by employees’ turnover intentions. The current study demonstrates that the HR department in hotels holds a powerful position, and therefore, hotel employees expect their HR department to play greater and proactive roles in the HRM apart from providing equitable opportunities for their growth. This implication is particularly important for Integrated Resorts where a large number of employees collectively work to serve a range of customers who visit hotels for a variety of purposes.Practical implicationsThis study suggests that addressing employees’ needs particularly those related to resolving complaints and managing relationships with other colleagues and providing opportunities for employees’ family members to take part in the organization’s activities and use its facilities are important practices that HR department can initiate to encourage employees’ engagement in hotels. Furthermore, the study shows that managers need to understand their employees’ perspectives as they can help resolve problems at the root level where they grow, and send a signal to the employees that the management is genuinely interested in resolving their problems and making them happy and satisfied.Originality/valueAlthough several studies have provided valuable insights into the relationship between HRM practices and employee turnover intentions, most of those studies have used quantitative approaches to collect and analyze data. Furthermore, almost none of the findings were derived from the hotel sector. This study explores hotel employees’ views on the relationship between HRM practices and employee turnover intention using qualitative methods.
Newly professionalised physiotherapists: symbolic or substantive change?
Authors: Anderson Pauline , Warhurst Chris 
Published: December 2019

PurposeThere is renewed interest in the professions as a range of occupations pursue professionalisation projects. The purpose of this paper is turn analysis to an important omission in current research – the skills deployed in the work of these professions. Such research is necessary because skills determine the formal classification of occupations as a profession.Design/methodology/approachDrawing on qualitative research, this paper explores the deployment of skills in work of one newly professionalised occupation in the UK’s National Health Service – physiotherapists.FindingsThe findings point to a disconnect between how this occupation has become a profession (the skills to get the job, and related political manoeuvring by representative bodies) and the mixed outcomes for their skills deployment (the skills to do the job) in work as a profession.Originality/valueThe paper provides missing empirical understanding of change for this new profession, and new conceptualisation of that change as both symbolic and substantive, with a “double hybridity” around occupational control and skill deployment for physiotherapists as a profession.
Effectuation theoretical debate: systematic review and research agenda
Authors: Dias Suzi Elen Ferreira , Sadao Iizuka Edson , Vilas Boas Eduardo Pinto 
Published: December 2019

Purpose
The purpose of this paper is to understand the theoretical discussion of effectuation since the seminal paper in 2001 and to propose an agenda for future studies.

Design/methodology/approach
Systematic literature review and content analysis of 71 papers.

Findings
Most papers performed a replication of the concepts empirically, and few studies proposed to understand theoretical aspects of effectuation, among them, some authors presented theoretical advances to improve the approach and others participated in an ongoing debate that shows there is no consensus on whether the approach is theory or if considered, appears to be under construction at a rudimentary level or being questioned.

Research limitations/implications
The method requires authors to make choices, so the database used and the criteria defined for searching papers that were analyzed are the main limitations of this research.

Practical implications
The authors suggest that researchers, teachers and practitioners use effectuation analytically and reflectively.

Social implications
The authors present and analyze the current theoretical debate on effectuation. Results suggest the need for new discussions about the concepts, as well as new theoretical efforts of the researchers to analyze the potentialities and limitations of this approach.

Originality/value
Among empirical and applied research, with replications of the concepts of effectuation, this research contributes to a theoretical discussion based on a systematic literature review, seeking to bring new reflections about this approach. Additionally, the authors present an agenda of theoretical gaps for the development of future research.
Channel capability and the effectiveness of new product strategies
Authors: Trihatmoko Roderikus Agus , Mulyani Roch , Q.A. Intan Novela 
Published: December 2019

Purpose
The purpose of this paper is twofold: detecting, describing and providing a detailed understanding on the essence of buyer responses on the channel capability in deciding new product purchase; and describing the effectiveness of new product innovation related to the channel capability. The new product innovation intended here is an outcome of the brand strategy created by the fast-moving consumer goods (FMCG) manufacturer.

Design/methodology/approach
This research applies qualitative method and uses grounded theory approach and pragmatism interpretation, which are focused on FMCG. The approach chosen in research is grounded theory and pragmatism, parallel to the previous phenomenology and constructivism approach; therefore, the main data for this study use transcript records of the results of in-depth interviews in the field of study.

Findings
The research showed the following results: the channel capability aspects (warehouse space, shelf space and customer coverage) are the essence of buyers’ responses; construction of business buyer behavior and economic mechanism; the effectiveness of new product innovation; and channel capabilities of selling products.

Practical implications
The results of this research have some implications: developing the concept of business buyer behavior in a new-task purchase situation; expanding the micro-economic system of trading sector; and expanding the concept of marketing mix strategy.

Originality/value
Some of the theoretical implications are the originality of this research paper; therefore, the constructs will be described theoretically in order to provide practical understanding in some contexts of business importance.
Eventful futures and triple bottom line impacts: BRICS, image regeneration and competitiveness
Authors: Wise Nicholas 
Published: December 2019

Purpose
There are many ways of viewing, interpreting and even conceptualizing Brazil, Russia, India, China and South Africa (BRICS) growth. This paper considers image regeneration and how this helps enhance place competitiveness. A focus on events and the spectacle they create also challenges to think about sustainable futures. This paper aims to supplement this focus on image regeneration and competitiveness, it is important to discuss and outline triple bottom line impacts as a framework to consider going forward.

Design/methodology/approach
Looking at the BRICS, the growing events, tourism and leisure industries transcend private and public business practices and can help align with more contemporary sustainable development practices and regeneration agendas. Such agendas can, in turn, help enhance destination competitiveness and image. While the authors need (and should) continue to assess and address economic impacts and development, it is just as important to consider environmental impacts and social impacts on a destination and its residents when considering competitiveness.

Findings
This conceptual paper frames insight from the literature to reflect on and consider research directions linked to triple bottom line impacts. The paper puts emphasis on the need to consider the social and environmental impacts of events.

Originality/value
This paper links conceptual discussions of image regeneration and competitiveness with triple bottom line impacts to look at directions for BRICS nations. It is useful for policymakers and planners who look at the “big picture” of event hosting and argues the need for more sustainable policy and planning agendas.
Predictive factors for work‐day loss in Behçet's syndrome: A multi‐center study
Authors: Mumcu Gonca , Yay Meral , Aksoy Aysun , Taş Mehmet Nedim , Armağan Berkan , Sarı Alper , Bozca Burçin Cansu , Tekgöz Emre , Karadağ Duygu Temiz , Badak Suade Özlem , Tecer Duygu , Bes Cemal , Şahin Ali , Erken Eren , Cefle Ayse , Çınar Muhammet , Yılmaz Sedat , Karaçaylı Ümit , Alpsoy Erkan , Şenel Soner , Yaşar Bilge Şule , Kaşifoğlu Timuçin , Karadağ Ömer , Aksu Kenan , Keser Gökhan , Alibaz‐Öner Fatma , İnanç Nevsun , Ergun Tülin , Direskeneli Haner 
Published: December 2019

AbstractObjectiveThe aim of this multi‐center study was to assess predictive factors for work‐day loss as an indirect cost element in Behçet's syndrome (BS).MethodsIn this cross‐sectional, multi‐center study, 834 BS patients (F/M: 441/393, age mean: 38.4 ± 10.9 years) were included. Data were collected by a questionnaire regarding treatment protocols, disease duration, smoking pattern, frequency of medical visits during the previous year and self‐reported work‐day loss during the previous year.ResultsWork‐day loss was observed in 16.2% of patients (M/F: 103/32). The percentages of being a smoker (81.8%), using immunosuppressive (IS) medications (82%), and having disease duration <5 years (74%) were higher in male patients with work‐day loss (P < .05). The majority of males (90.9%) had more than four clinic visits during the previous year. Moreover, the mean work‐day loss (30.8 ± 57.7 days) was higher in patients with vascular involvement (56.1 ± 85.9) than those without (26.4 ± 50.6 days) (P = .046). In addition, increased frequency of ocular involvement (25.9%) was also observed in patients with work‐day loss compared to others (8.6%) (P = .059).ConclusionWork‐day loss was associated with both vascular and ocular involvement. Close associations were observed among male gender, early period of the disease, frequent medical visits, being a smoker and treatment with IS medications in patients with work‐day loss.
On the AIIB’s Non‐resident Board: Strategic Trade‐offs, Roles and Responsibilities
Authors: von Müller Camillo , Baumann Elke 
Published: December 2019

AbstractThe AIIB’s non‐resident Board of Directors has drawn a lot of attention among experts and in the literature, although it is not an unprecedented feature among the existing international financial institutions. A non‐resident Board setting has implications for how the respective Board undertakes its role and responsibilities. This essay analyses the characteristics of the AIIB’s non‐resident board in regard to four roles or functions as defined in the literature on Board evaluation (Martinez‐Diaz 2008), that is, the roles of strategic thinker, political counterweight, performance police, and democratic forum. AIIB’s Board of Directors is particularly apt to perform the role of a strategic thinker, while taking on the other roles to different degrees of effectiveness.
Australian orthopaedic surgery training: Australian Orthopaedic Association's strategic education review
Authors: Incoll Ian W. , Atkin Jodie , Owen John , Keane Ally , Khorshid Omar , Cosenza Adrian , Frank Jason 
Published: December 2019

AbstractBackgroundThe Australian Orthopaedic Association (AOA) is the peak professional body for orthopaedic surgeons in Australia and is responsible for their training and continuing medical education. The 2012 AOA strategic education review employed a gap analysis to identify issues and generate a roadmap for the enhancement of AOA's education and training activities. This paper describes the process and outcomes of this review, which led to the ‘AOA 21’ Education Re‐design Project, and the review's relevance to surgical education in Australia.MethodsThe AOA strategic education review was undertaken by international clinician education and orthopaedic experts, and involved AOA staff, fellows and trainee members throughout Australia. This review progressed through four phases: a review of current training; a global ‘best‐practice’ perspective; a set of aspirational goals; and a roadmap for implementation.ResultsSeven key strengths (e.g. camaraderie in training and surgical skills teaching) and 15 challenges (e.g. ‘non‐technical’ skills teaching, subjective methods of decision making and inadequate assessment practices) were identified in the review stage. Sixteen major recommendations for improvements incorporating current or emerging world's best education practices were targeted in an 8‐year implementation framework.ConclusionThe AOA's strategic education review serves as a roadmap for other specialty training organizations to review their programmes and implement contemporary best practices in surgical training. The AOA 21 project has positioned orthopaedic surgery as a leader in competency‐based surgical education and training in Australia.
Practical management of tumour lysis syndrome in venetoclax‐treated patients with chronic lymphocytic leukaemia
Authors: Gribben John G. 
Published: December 2019

SummaryThe treatment landscape in relapsed/refractory chronic lymphocytic leukaemia (CLL) has rapidly evolved over the past five years, with one such emergent treatment being the BCL2 inhibitor, venetoclax. This oral treatment has demonstrated significant clinical advantages in indicated patients, but rapid tumour debulking can lead to a treatment‐related risk of the acute condition known as tumour lysis syndrome (TLS). Here, I present real patient cases to show how I have used the recommended predose monitoring and prophylactic procedures to mitigate the risk of TLS. I also used the ramp‐up dose escalation schedule of venetoclax therapy initiation to safely take patients through the treatment, successfully providing them with sustained clinical benefits.
Benefit from extended surveillance interval on colorectal cancer risk in Lynch syndrome
Authors: Lindberg L. J. , Rasmussen M. , Andersen K. K. , Nilbert M. , Therkildsen C. 
Published: December 2019

AbstractAimAlthough patients with Lynch syndrome have an increased risk of developing colorectal cancer, surveillance can reduce morbidity and mortality. Whether or not affected individuals benefit from lifetime surveillance depends on individual factors and patient adherence, and these may vary, complicating risk modelling. The aim of this study was to identify individual factors which influence patient adherence to surveillance programmes and whether extended surveillance interval influenced their risk of developing colorectal cancer.MethodDemographics and survival data were obtained from patients (n = 1223) with Lynch syndrome, identified by interrogating the Danish Hereditary Non‐Polyposis Colorectal Cancer Register. These data were linked to patient surveillance interval data which had been divided into three subsets (< 27 months, adherent to the recommended biennial programme; > 27 months, extended surveillance interval; and no surveillance) to estimate the cumulative risks and hazard ratios (HRs) for colorectal cancer.ResultsIn all, 147 colorectal cancers (99 first; 48 metachronous) were identified in 1223 patients. Factors associated with adherence to surveillance were female sex, a previous history of cancer and age < 75 years. The cumulative incidence for colorectal cancer was 38% (95% CI 27%–50%) for surveillance intervals < 27 months, 48% (95% CI 29%–67%) for intervals > 27 months and 72% (95% CI 61%–83%) with no surveillance. Adjusted HRs were 0.22 for surveillance intervals < 27 months and 0.32 for surveillance intervals > 27 months. Extended surveillance intervals > 27 months had a non‐significant benefit with an HR of 1.51 (95% CI 0.83–2.75) compared to surveillance intervals < 27 months.ConclusionThis study demonstrates that adherence to colonoscopic surveillance in Lynch syndrome varies with age, sex and cancer history and demonstrates a consistent benefit from colorectal cancer surveillance, though it might be lower for individuals with extended intervals.