bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-perspectives crowdsourcing ecosystem in Malaysia
Authors: Janom Norjansalika , Azhani Raja Nurul , Syed Aris Syaripah Ruzaini , Bashah Nor Shahniza Kamal , Arshad Noor Habibah , Nadir Muhammad Hakim 
Published: May 2020

Crowdsourcing has been known as developing industry that able to be used as a platform to get more income and provide opportunity for busineses to conduct their operation in more innovative ways. Crowdsourcing has become an effective way for the companies to offer work opportunity for crowd outside organization to apply their abilities and skills, and receive more money. Under the Malaysian government initiatives called Digital economy, various crowdsourcing efforts and programs have been introduced to catch up with the global development. The ecosystem of crowdsourcing which consists of job provider, platform, micro worker and industry is considered still in a formative stage. Thus, the integration of all these components is not fully discovered and understood yet which, can cause confusion among the crowdsourcing industry players. In order to understand the complex integration of multi perspective micro sourcing ecosystem, the components and its significance priority level need to be identified. In this study, the components that involved in crowdsourcing ecosystem were identified and ranked using analytical hierarchy process (AHP) method. The results can be later used by crowdsourcing industry players to plan more proper crowd sourcing strategic development in Malaysia.
Heart Failure Risk Associated With Rheumatoid Arthritis–Related Chronic Inflammation
Authors: Ahlers Michael J. , Lowery Brandon D. , Farber‐Eger Eric , Wang Thomas J. , Bradham William , Ormseth Michelle J. , Chung Cecilia P. , Stein C. Michael , Gupta Deepak K. 
Published: May 2020

Background

Inflammation may contribute to incident heart failure (
HF
). Rheumatoid arthritis (
RA
), a prototypic inflammatory condition, may serve as a model for understanding inflammation‐related
HF
risk.

Methods and Results

Using the Vanderbilt University Medical Center electronic health record, we retrospectively identified 9889 patients with RA and 9889 control patients without autoimmune disease matched for age, sex, and race. Prevalent
HF
at entry into the electronic health record or preceding
RA
diagnosis was excluded. Incident
HF
was ascertained using
International Classification of Diseases, Ninth Revision (ICD‐9),
codes and medications. Over 177 566 person‐years of follow‐up, patients with
RA
were at 21% greater risk of
HF
(95% CI, 3–42%) independent of traditional cardiovascular risk factors. Among patients with
RA
, higher CRP (C‐reactive protein) was associated with greater
HF
risk (
P
<0.001), while the anti‐inflammatory drug methotrexate was associated with ≈25% lower
HF
risk (
P
=0.021). In a second cohort (n=115) of prospectively enrolled patients with and without
RA
, we performed proteomics and cardiac magnetic resonance imaging to discover circulating markers of inflammation associated with cardiac structure and function. Artemin levels were higher in patients with RA compared with controls (
P
=0.009), and higher artemin levels were associated with worse ventricular end‐systolic elastance and ventricular‐vascular coupling ratio (
P
=0.044 and
P
=0.031, respectively).

Conclusions

RA
, a prototypic chronic inflammatory condition, is associated with increased risk of
HF
. Among patients with
RA
, higher levels of CRP were associated with greater
HF
risk, while methotrexate was associated with lower risk.
Prediction of Residual Risk by Ceramide‐Phospholipid Score in Patients With Stable Coronary Heart Disease on Optimal Medical Therapy
Authors: Hilvo Mika , Wallentin Lars , Ghukasyan Lakic Tatevik , Held Claes , Kauhanen Dimple , Jylhä Antti , Lindbäck Johan , Siegbahn Agneta , Granger Christopher B. , Koenig Wolfgang , Stewart Ralph A. H. , White Harvey , Laaksonen Reijo ,   the STABILITY Investigators
Published: May 2020

Background

Identification of patients with stable coronary heart disease who are at significant residual risk could be helpful for targeted prevention. Our aim was to determine the prognostic value of the recently introduced ceramide‐ and phospholipid‐based risk score, the Cardiovascular Event Risk Test (
CERT
2), in patients with stable coronary heart disease on optimal medical therapy and to identify biological processes that contribute to the
CERT
2 score.

Methods and Results

Plasma samples (n=11 222) obtained from the
STABILITY
(Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial were analyzed using a tandem liquid chromatography‐mass spectrometry method.
STABILITY
was a trial in patients with stable coronary heart disease randomized to the lipoprotein‐associated phospholipase A2 inhibitor darapladib or placebo on optimized medical therapy at baseline, with a median follow‐up of 3.7 years. Hazard ratios per
SD
for the
CERT
2 risk score were 1.32 (95% CI, 1.25–1.39) for major adverse cardiovascular event, 1.47 (95% CI, 1.35–1.59) for cardiovascular death, 1.32 (95% CI, 1.16–1.49) for stroke, 1.23 (95% CI, 1.14–1.33) for myocardial infarction, and 1.56 (95% CI, 1.39–1.76) for hospitalization due to heart failure, when adjusted for traditional cardiovascular risk factors.
CERT
2 showed correlation (
P
<0.001,
r
>0.2) with inflammatory markers high‐sensitivity C‐reactive protein, interleukin 6, the heart failure marker N‐terminal pro‐B‐type natriuretic peptide, and low‐density lipoprotein cholesterol. After also adjusting for levels of other prognostic biomarkers, the
CERT
2 score was still independently related to the risk of cardiovascular death but not to nonfatal events.

Conclusions

The
CERT
2 risk score can detect residual risk in patients with stable coronary heart disease and is associated with biomarkers indicating inflammation, myocardial necrosis, myocardial dysfunction, renal dysfunction, and dyslipidemia.

REGISTRATION

URL
:
https://www.clini​caltr​ials.gov
. Unique identifier:
NCT
00799903.
Motor Timing as a Predictor of Attention, Working Memory and Impulsivity in Alcohol and/or Cocaine Use Disorders
Authors: Young S.Y. , van Hoof J.J.M. , Kidd M. , Seedat S. 
Published: May 2020

In recent years, there has been a growing interest in neuropsychological deficits in patients with Cocaine Use Disorder (CUD) and Alcohol Use Disorder (AUD). Besides deficits in working memory (WM), impulsivity and attention, chronic alcohol and cocaine use have neurotoxic effects on frontostriatal areas in the brain. Individuals with deficits in these brain regions experience motor-timing deficits. It is unclear whether observed temporal processing deficits, in fact, reflect increased sustained attention or WM demands (which are required by timing tasks), or whether motor-timing deficits reflect some other process. The main questions of this
were: (i) Can attention and WM be explained by motor-timing performance, and (ii), is impulsivity related to motor timing performance, in an inpatient SUD population? The study sample consisted of 74 abstinent patients who completed selected neuropsychological and motor-timing tasks. No significant correlation was found between performance on motor tasks and impulsivity. With regard to visual and auditory WM, motor timing was a significant predictor but only under conditions that required increased cognitive demands. Motor-timing performance contributed to a small portion of the variance in attention, but only for spatial abilities and only at increased cognitive demands. These preliminary findings suggest that, in line with the literature, millisecond timing engages other cognitive functions, but only minimally. As such motor timing should be regarded as a separate neurocognitive concomitant. Impulsivity was not associated with millisecond motor timing. More research is needed to further investigate these preliminary findings.
Multimodel Ensemble Forecasts of Precipitation Based on an Object-Based Diagnostic Evaluation
Authors: Ji Luying , Zhi Xiefei , Simmer Clemens , Zhu Shoupeng , Ji Yan 
Published: May 2020

Abstract
We analyzed 24-h accumulated precipitation forecasts over the 4-month period from 1 May to 31 August 2013 over an area located in East Asia covering the region 15.05°–58.95°N, 70.15°–139.95°E generated with the ensemble prediction systems (EPS) from ECMWF, NCEP, UKMO, JMA, and CMA contained in the TIGGE dataset. The forecasts are first evaluated with the Method for Object-Based Diagnostic Evaluation (MODE). Then a multimodel ensemble (MME) forecast technique that is based on weights derived from object-based scores is investigated and compared with the equally weighted MME and the traditional gridpoint-based MME forecast using weights derived from the point-to-point metric, mean absolute error (MAE). The object-based evaluation revealed that attributes of objects derived from the ensemble members of the five individual EPS forecasts and the observations differ consistently. For instance, their predicted centroid location is more southwestward, their shape is more circular, and their orientation is more meridional than in the observations. The sensitivity of the number of objects and their attributes to methodological parameters is also investigated. An MME prediction technique that is based on weights computed from the object-based scores, median of maximum interest, and object-based threat score is explored and the results are compared with the ensemble forecasts of the individual EPS, the equally weighted MME forecast, and the traditional superensemble forecast. When using MODE statistics for the forecast evaluation, the object-based MME prediction outperforms all other predictions. This is mainly because of a better prediction of the objects’ centroid locations. When using the precipitation-based fractions skill score, which is not used in either of the weighted MME forecasts, the object-based MME forecasts are slightly better than the equally weighted MME forecasts but are inferior to the traditional superensemble forecast that is based on weights derived from the point-to-point metric MAE.
A Randomized Sham-controlled Trial of 1-Hz and 10-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) of the Right Dorsolateral Prefrontal Cortex in Civilian Post-traumatic Stress Disorder: Un essai randomisé contrôlé simulé de stimulation magnétique transcrânienne repetitive (SMTr) de 1 Hz et 10 Hz du cortex préfrontal dorsolatéral droit dans le trouble de stress post-traumatique chez des civils
Authors: Leong Kawai , Chan Peter , Ong Larry , Zwicker Amy , Willan Sharon , Lam Raymond W. , McGirr Alexander 
Published: May 2020

Objective: Despite effective psychological and pharmacological treatments, there is a large unmet burden of illness in post-traumatic stress disorder (PTSD). Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive intervention and a putative treatment strategy for PTSD. The evidence base to date suggests that rTMS targeting the dorsolateral prefrontal cortex (DLPFC), in particular the right DLPFC, leads to improvements in PTSD symptoms. However, optimal stimulation parameters have yet to be determined. In this study, we examine the efficacy of high- and low-frequency rTMS of the right DLPFC using a randomized, double-blind, sham-controlled design in civilian PTSD. Methods: We conducted a 2-week single-site randomized sham-controlled trial of rTMS targeting the right DLPFC. We recruited civilians aged 19 to 70 with PTSD and randomized subjects with allocation concealment to daily 1-Hz rTMS, 10-Hz rTMS, or sham rTMS. The primary outcome was improvement in Clinician Administered PTSD Scale–IV (CAPS-IV). Secondary outcomes included change in depressive and anxiety symptoms. Results: We recruited 31 civilians with PTSD. One 1-Hz-treated patient developed transient suicidal ideation. Analyses revealed significant improvement in CAPS-IV symptoms in the 1-Hz group relative to sham (Hedges’ g = −1.07) but not in the 10-Hz group. This was not attributable to changes in anxious or depressive symptomatology. Ten-Hz stimulation appeared to improve depressive symptoms compared to sham. Conclusion: Low-frequency rTMS is efficacious in the treatment of civilian PTSD. Our data suggest that high-frequency rTMS of the right DLPFC is worthy of additional investigation for the treatment of depressive symptoms comorbid with PTSD.
European real-world data about the use of a new delivery system containing a preservative-free multi-dose glaucoma treatment
Authors: Denis Philippe , Duch Susana , Chen Enping , Klyve Per , Skov Jesper , Puska Païvi , Erb Carl 
Published: May 2020

Background Glaucoma treatments are mostly presented in uni-dose or multi-dose format. A certain number of patients with visual acuity and dexterity problems may have problems in instilling eye drops. Aim To assess patient satisfaction and ease of use of a preservative-free glaucoma treatment (dorzolamide/timolol) in a new and innovative patented multi-dose delivery system. Methods Retrospective, international, multicentre, non-interventional study in 788 adult patients using a multi-dose delivery system for at least 28 days. Results Mean patient age was 68.1 ± 12.1 years. Mean duration of multi-dose delivery system use was 132.1 ± 125.1 days; 66.5% of the patients previously used multi-dose and 33.5% uni-dose delivery systems (n = 734); 78.3% of the patients were satisfied or very satisfied with the multi-dose delivery system. A significant majority (all p ≤ 0.045) of patients with a QuickDash® score between [0 to 25[ (66.4%, n = 211) and [50 to 75[ (81.8%, n = 11) rated multi-dose delivery system as easy or very easy to open and significantly more subjects in the [0 to 25[ (72%) score group rated multi-dose delivery system as being better or much better than their previous device (n = 211). Significantly (all p < 0.01) more subjects with available visual acuity results rated multi-dose delivery system as good, better or much better than their previous dispensing device. Conclusion The tested multi-dose delivery system was highly accepted. It is, therefore, suitable for glaucoma patients with decreased visual acuity and/or dexterity problems. Further studies may be necessary to assess the easiness of use of this easy-to-grip delivery system.
Chronic Postoperative Pain After Hysterectomy for Endometrial Cancer: A Metabolic Profiling Study
Authors: Lunde Søren , Nguyen Hien TT , Petersen Kristian K , Arendt-Nielsen Lars , Krarup Henrik B , Søgaard-Andersen Erik 
Published: May 2020

Introduction One out of seven women will develop a state of chronic postoperative pain following robot-assisted hysterectomy for endometrial cancer. Recently, metabolic studies have indicated that circulating lipids and lipoproteins could act as nociceptive modulators and thereby influence the induction and perpetuation of pain. The objectives of this explorative study were (1) to examine the preoperative serologic variations in concentrations of lipids, lipoproteins, and various low‐molecular metabolites in patients with and without chronic postoperative pain after robot-assisted hysterectomy and (2) to explore if any of these serological biomarkers were predictive for development of chronic postoperative pain. Materials and Methods The study was designed as a nested case–control study within a cohort of women treated for endometrial cancer with robot-assisted laparoscopic hysterectomy. Twenty-six women with chronic postoperative pain were matched on age and body mass index with fifty-two controls without chronic postoperative pain, and metabolic profiling of preoperatively drawn blood samples from a biobank was performed by means of nuclear magnetic resonance spectroscopy. Results Nineteen metabolites, including cholesterol, cholesteryl ester, linoleic acid, phospholipids, lipids, and triglycerides had statistically significant higher concentrations in a subgroup of patients who would develop chronic postoperative pain on a later stage compared to the group of patients who would not develop chronic postoperative pain ( p <  0.05). A sparse Partial Least Squares-Discriminant Analysis model explained 38.1% of the variance and had a predictive accuracy of 73.1%. Conclusions This explorative study substantiates the hypothesis that certain lipids, lipoproteins, and fatty acids are associated with chronic postoperative pain.
Streamlined haematuria pathway: Reduced waiting times and improved cost benefits
Authors: Wood Brielle E , Kim Jason , Donato Peter , Mostyn Jenna , McClintock Scott 
Published: May 2020

Objectives: Haematuria is a common urological complaint that carries a significant burden to our healthcare system. Due to the complex investigation algorithm for haematuria, incomplete referrals result in multiple appointments. We established the “streamlined haematuria pathway” (SHP) phone clinic, and this study evaluated the effect of SHP on waiting times, patient care and time to treatment. Methods: A retrospective analysis of all patients who were reviewed via our SHP was performed, including time to see and outcomes. The effects of implementing the SHP on our health system were assessed by analysing our referral waitlists and costings department. Results: On starting the SHP phone clinic there were 1031 referrals waiting longer than clinical recommended time frames, and of these 92 were identified as a patient with haematuria. The majority of patients were male sex (55%), had microscopic haematuria (63%), and the median age was 69 years. There were 12 (30%) patients who were waiting 100 days or more before the phone clinic was introduced. A total of 87% patients were discharged post-normal outcomes, 5% patients had stones and 8% patients were diagnosed with bladder malignancy. Conclusions: The SHP phone clinic is an effort to decrease morbidity and mortality by earlier diagnosis of urological malignancy. Level of evidence: 3-b
Acceptance of Traditional Chinese Medicine in the Neonatal Intensive Care Unit: A Launching Point
Authors: Johnson Rolfes Julie , Christensen Kimberly , Gershan Lynn A 
Published: May 2020

Background Because neonatology is a relatively new medical specialty, it is host to on-going, rapid adaptation and evolution of medical treatments and practices. This process has almost exclusively focused on Western, biomedical treatment modalities, without inclusion of potentially beneficial Traditional Chinese Medicine practices. It is unclear how receptive health-care providers in the neonatal intensive care unit (NICU) and families of NICU patients would be to the introduction of adapted Traditional Chinese Medicine treatments into the NICU environment. Objective To assess the potential for engagement of patients, families, and staff in the NICU with Traditional Chinese Medicine therapies and to provide targeted education and low-risk Traditional Chinese Medicine treatments to support the health and well-being of those 3 groups. Methods A feasibility pilot study including weekly walk-in Traditional Chinese Medicine sessions within the NICU for parents and staff, and neonatal patient consultations, both of which included hands-on therapies and education tailored to each participant's unique needs. Pre- and postsurveys were administered over 3 phases. Results Walk-in sessions were attended by 83 adults and participants reported benefits, with no ill effects. There were 5 neonatal consultations with staff expressing an interest in more. Several obstacles to accessing Traditional Chinese Medicine modalities were identified in pre-surveys and were addressed with education and preemptive modifications to the therapies offered. Conclusion Acceptance of Traditional Chinese Medicine modalities in the NICU opens the door to future studies implementing integrative health services into the NICU care model.
Selective Fusion in Lenke 1 B/C: Before or After Menarche?
Authors: Davies Nestor Ricardo , Tello Carlos , Piantoni Lucas , Remondino Rodrigo , Galaretto Eduardo , Wilson Ida Alejandra Francheri , Rodriguez Victor Vasquez , Bersusky Ernesto , Noel Mariano 
Published: May 2020

Study Design: A retrospective, comparative study. Objective: To determine the radiological behavior of the lumbar curve in selective fusions in premenarchal girls with adolescent idiopathic scoliosis (Lenke 1 B/C). Methods: A retrospective, comparative study was conducted. Selective fusion was performed in 21 patients younger than 18 years. The patients were divided into 2 groups: group A, after menarche (n = 12) and group B, before menarche (n = 9). Angles (preoperative, and at 1 and 2 years postoperatively) of the fused thoracic curves and the corresponding lumbar curves were measured and compared. For statistical analysis, the t test was used with a significance level of P < .05. Results: Mean preoperative angle value of the proximal/main thoracic curve was 61° in group A and 57° in group B ( P = .44), and 21° and 20°, respectively, in the first year postoperatively ( P = .61). Mean preoperative angle value of the lumbar curve was 43° in group A and 42° in group B ( P = .87), while at 1 year after surgery, this curve was 19° in both groups ( P = 0.91), and at 2 years postoperatively, the curve was 16° in group A and 17° in group B ( P = .75). Conclusions: Over a 2-year follow-up, we did not find significant radiological differences in lumbar curves between patients who underwent surgery before and after menarche.
Does L5-S1 Anterior Lumbar Interbody Fusion Improve Sagittal Alignment or Fusion Rates in Long Segment Fusion for Adult Spinal Deformity?
Authors: Meyers Andrew J. , Wick Joseph B. , Rodnoi Pope , Khan Ahsan , Klineberg Eric O. 
Published: May 2020

Study Design: Retrospective cohort study. Objectives: To assess whether the addition of L5-S1 anterior lumbar interbody fusion (ALIF) improves global sagittal alignment and fusion rates in patients undergoing multilevel spinal deformity surgery. Methods: Two-year radiographic outcomes, including lumbar lordosis, pelvic incidence, pelvic tilt, and T1 pelvic angle; hardware complications; and nonunion/pseudarthrosis rates were compared between patients who underwent lumbosacral fusion at 4 or more vertebral levels with and without L5-S1 ALIF between November 2003 and September 2016. Results: A total of 51 patients who underwent fusion involving a mean of 11.1 levels with minimum 2-year postoperative radiographic follow-up data were included. Patients who underwent L5-S1 ALIF did not have significant improvement in global sagittal alignment parameters and demonstrated a trend toward a higher rate of nonunion and hardware failure. Conclusions: L5-S1 ALIF did not confer significant benefit in terms of global sagittal alignment and fusion rates in patients undergoing multilevel lumbosacral fusion. Given these results and that L5-S1 ALIF is associated with increased surgical morbidity, surgeons should be judicious in including L5-S1 ALIF in large multilevel constructs.