bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Glucocorticoid Use and Cancer Risk: A Population-Based Cohort Study in South Korea
Authors: Oh Tak Kyu , Song In-Ae 
Published: August 2020

Abstract

Long-term glucocorticoid (GC) exposure causes immunosuppression; therefore, the risk of cancer may be increased in long-term GC users. We investigated whether long-term GC use is associated with a higher risk of cancer in the population without cancer. A population-based cohort study using data from the National Health Insurance Service was conducted among the South Korean adult population in 2010. Long-term GC users were defined as those who were prescribed a continuous supply of oral GC for ≥30 days. The primary endpoint was a new cancer diagnosis from January 1, 2011, to December 31, 2015. Among 770,880 individuals included in the analysis, 1,602 (0.2%) were long-term GC users and 36,157 (4.7%) were newly diagnosed with cancer from January 2011 to December 2015. In the multivariable Cox regression analysis, the risk of cancer among long-term GC users was 1.23-fold higher than that of the unexposed individuals [95% confidence interval (CI), 1.06–1.43; P = 0.007]. In the competing risk analyses, the risks of liver cancer and lung cancer were 1.46-fold (95% CI, 1.03–2.07; P = 0.034) and 1.52-fold (95% CI, 1.04–2.21; P = 0.029) higher in the long-term GC users than that of the unexposed individuals, respectively. We found that long-term GC exposure might be associated with a higher risk of overall cancer, and this association was more evident for lung and liver cancer risk. However, because there might be unmeasured and potential confounders in this study, the results should be interpreted carefully, and future studies should be performed to confirm these findings.

Impact:
Long-term glucocorticoid therapy might be associated with a higher cancer risk. This association was more evident for lung and liver cancer risk. Our findings suggest that long-term prescriptions of glucocorticoids should be administered carefully considering the risk of cancer.
Immune Checkpoint Inhibition is Safe and Effective for Liver Cancer Prevention in a Mouse Model of Hepatocellular Carcinoma
Authors: Chung Andrew S. , Mettlen Marcel , Ganguly Debolina , Lu Tianshi , Wang Tao , Brekken Rolf A. , Hsiehchen David , Zhu Hao 
Published: August 2020

Abstract
Cirrhosis is a high-risk state for hepatocellular carcinoma (HCC) development and represents an opportunity to prevent cancer. In the precancerous state of cirrhosis, there is an accumulation of neoantigens that may be specifically targetable through immunotherapy. We asked whether immune checkpoint inhibition could prevent tumorigenesis in a mouse model of diethylnitrosamine and carbon tetrachloride–induced HCC. We found that initiation of anti-PD-1 therapy prior to tumorigenesis could prevent up to 46% of liver tumors. This significant reduction in tumor burden was accompanied by infiltration of CD4+ Th cells and CD8+ cytotoxic T cells into the liver parenchyma. Importantly, anti-PD-1 therapy did not exacerbate liver dysfunction or worsen overall health in this liver disease model. Given the safety and preservation of quality of life observed with long-term immunotherapy use, an immunotherapy chemoprevention strategy is likely associated with a low risk-to-benefit ratio and high value care in select patients. These results encourage a prevention trial in cirrhotic patients with the highest risk of developing HCC.
See related Spotlight by Mohammed et al., p. 897
How Does Obesity Drive Human Carcinogenesis? Challenges in Dissecting the Mechanisms of Adipose–Epithelial Signaling
Authors: Colacino Justin , Djuric Zora , Brenner Dean E. 
Published: August 2020

Abstract
Obesity is the second leading environmental association with cancer risk; yet, the mechanisms by which obesity drives carcinogenesis are poorly understood. The paper published in this issue of Cancer Prevention Research by Holowatyj and colleagues explores the mechanisms of human visceral adipose–epithelial signaling using samples collected at surgery in patients with invasive colorectal cancer. They identify pathway intermediates potentially involved in the regulation of fibrosis, inflammation, glycosis, and epithelial–mesenchymal transition in neoplastic tissue. ‘Omics-based profiling of perioperative human biosamples has potential for inherent biases (preoperative and intraoperative drug therapies, hydration, dynamics, inflammatory response to surgical intervention) and appropriate control samples are difficult to identify and collect. Solutions to this dilemma may include strategies to identify patients undergoing similar surgical procedures but who are without neoplasms, for example, patients with gynecologic problems, abdominal exploration for suspected appendicitis, symptoms or resection of gall stone disease or undergoing bariatric surgery. As the field continues to grow, studies incorporating robust statistical analyses, validation of findings in diverse cohorts, and public data sharing will be essential to identify biological pathways linking obesity and carcinogenesis to be further interrogated using focused, hypothesis-driven approaches.
See related article by Holowatyj et al., p. 817
Zonas de cisalhamento normais no SW do Cráton Amazônico: análise microestrutural das rochas miloníticas do Granito Indiavaí
Authors: Silva Danielle Cristine da , Silva Carlos Humberto da , Costa Ana Cláudia Dantas da 
Published: August 2020

Zonas de cisalhamento dúcteis de cinemática normal em orógenos continentais previamente espessados por eventos orogênicos compressivos têm suscitado grande interesse na comunidade científica. Na porção sudoeste do Cráton Amazônico, na região de Indiavaí, porção centro-oeste do Brasil, ocorrem as zonas de cisalhamento Água Rica e Cristo Rei, que afetam as rochas do Granito Indiavaí. Análise das estruturas em escala mesoscópica revela progressiva transformação de um protólito granítico com foliação fraca, passando a rochas com textura protomilonítica, milonítica até ultramilonítica. Análise microestrutural demonstra gradual diminuição do tamanho dos grãos ocasionando o aumento da matriz. As rochas com foliação incipiente não apresentam matriz. Observam-se quartzo recristalizado, extinção ondulante nos feldspatos, intensos processos de sericitização no plagioclásio e ortoclásio com pertitas em chamas. Nos protomilonitos, a matriz perfaz de 20 a 30% da rocha e é composta de quartzo e biotita. São observados porfiroclastos de feldspato potássico, com fraturas, falhas e extinção ondulante. Nos milonitos, a matriz perfaz de 60 a 75% da rocha e é composta de quartzo, biotita e muscovita. Ocorrem porfiroclastos de quartzo comumente na forma de fitas, que apresentam recristalização por migração de limite de grão. Feldspato potássico e plagioclásio exibem extinção ondulante e recristalização por protuberância. Nos ultramilonitos predomina a matriz, que é basicamente composta de quartzo, muscovita e biotita de granulação média. Estima-se que os processos que atuaram no desenvolvimento da foliação milonítica ocorreram em temperaturas entre 400 e 600°C. Análise dos indicadores cinemáticos revela que o movimento tectônico foi normal. Interpreta-se que as zonas de cisalhamento Cristo Rei e Água Limpa são parte de um sistema de cisalhamento extensional desenvolvido em crosta intermediária durante período Toniano.
Different Enhancement of the East Asian Summer Monsoon under Global Warming and Interglacial Epochs Simulated by CMIP6 Models: Role of the Subtropical High
Authors: He Chao , Zhou Wen 
Published: August 2020

AbstractSoutherly wind in the lower troposphere is an essential feature of East Asian summer monsoon (EASM) circulation, which is reported to be enhanced under global warming scenarios and interglacial epochs. Based on an analysis of an ensemble of CMIP6 models, this study shows that the magnitude of intensification of the EASM circulation is much smaller under global warming scenarios than during interglacial epochs. Distinct changes in the western North Pacific subtropical high (WNPSH) are responsible for the different responses of the EASM circulation. The WNPSH is substantially enhanced during interglacial epochs, which acts to strengthen the southerly wind associated with the EASM on the western flank of the WNPSH. However, the change in the WNPSH is insignificant and cannot strengthen the EASM under global warming scenarios, and the weakly enhanced EASM circulation may be a direct response to intensified heating over the Tibetan Plateau. The land–ocean thermal contrast explains the different responses of the WNPSH. During interglacial epochs, the summertime surface warming over the subtropical North Pacific is much weaker than over Eurasia due to the large thermal inertia of the ocean to increased insolation, and the WNPSH is intensified as a response to the suppressed latent heating over the subtropical North Pacific. The fast response of the WNPSH to abrupt quadrupling of CO2 without sufficient ocean warming is an analog to the interglacial epochs, but it is offset by the effect of slow oceanic warming, resulting in an insignificant change of the WNPSH under global warming scenarios.
Influence of Madden–Julian Oscillation on the Intraseasonal Variability of Summer and Winter Monsoon Rainfall in the Philippines
Authors: Bagtasa Gerry 
Published: August 2020

AbstractThe present study investigates the influence of the Madden–Julian oscillation (MJO) on the intraseasonal variability of summer and winter monsoon rainfall in the Philippines. The monsoon wind–terrain interaction that gives rise to rainfall in the Philippines leads to a sharp contrast between west and east coast rainfall patterns during summer and winter monsoon seasons, respectively. During the summer monsoon season, the eastward-propagating MJO modulates tropical cyclone (TC) activity in the western North Pacific (WNP) on MJO phases 5–7. TC rainfall and remote TC precipitation due to Rossby wave response to TC heating induces strong southwesterly flow that enhances moisture transport and brings anomalous rainfall to the western region of the Philippines. On the other hand, during the winter season, an induced Matsuno–Gill-type pattern to the southeast of the Philippines influences the strength of the Asian winter monsoon. Active (inactive) convection in the tropical Maritime Continent and western Pacific during MJO phases 4–6 produces the anomalous Philippine Sea cyclonic (anticyclonic) circulation. The cyclonic (anticyclonic) anomaly leads to an enhanced (weakened) northeast monsoon flow and wet (dry) rainfall anomaly along the eastern Philippines.
Refraction and Straining of Near-Inertial Waves by Barotropic Eddies
Authors: Asselin Olivier , Thomas Leif N. , Young William R. , Rainville Luc 
Published: August 2020

AbstractFast-moving synoptic-scale atmospheric disturbances produce large-scale near-inertial waves in the ocean mixed layer. In this paper, we analyze the distortion of such waves by smaller-scale barotropic eddies, with a focus on the evolution of the horizontal wavevector k under the effects of straining and refraction. The model is initialized with a horizontally uniform (k = 0) surface-confined near-inertial wave, which then evolves according to the phase-averaged model of Young and Ben Jelloul. A steady barotropic vortex dipole is first considered. Shear bands appear in the jet region as wave energy propagates downward and toward the anticyclone. When measured at a fixed location, both horizontal and vertical wavenumbers grow linearly with the time t elapsed since generation such that their ratio, the slope of wave bands, is time independent. Analogy with passive scalar dynamics suggests that straining should result in the exponential growth of |k|. Here instead, straining is ineffective, not only at the jet center, but also in its confluent and diffluent regions. Low modes rapidly escape below the anticyclonic core such that weakly dispersive high modes dominate in the surface layer. In the weakly dispersive limit, k = −t∇ζ(x, y, t)/2 provided that (i) the eddy vertical vorticity ζ evolves according to the barotropic quasigeostrophic equation and (ii) k = 0 initially. In steady flows, straining is ineffective because k is always perpendicular to the flow. In unsteady flows, straining modifies the vorticity gradient and hence k, and may account for significant wave–eddy energy transfers.
Drain Placement During Bariatric Surgery, Helpful or Harmful?
Authors: Gray Edward C. , Dawoud Fakhry , Janelle Meredith , Hodge Michael 
Published: August 2020

Introduction Routine drain placement is still widely used in both sleeve gastrectomy (SG) and Roux en Y gastric bypass (REYGB). There is mounting evidence that drains may increase complication risk without preventing reoperation or other complications. Methods Data from 2017 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) Participant Use File was evaluated for drain use during laparoscopic REYGB and SG. Primary outcomes were superficial and deep surgical site infections (SSI), reintervention/reoperation, and readmission. Preoperative patient risk factors were also compared to evaluate for association with drain placement. Results A total of 148 260 patients fit the inclusion criteria. Drains were used in 23 190 (15.6%) cases and not used in 125 070 (84.4%). Drain placement during surgery was associated with increased odds of superficial SSI, deep incisional SSI, and organ space SSI. Patients with drains were found to have increased odds of requiring at least 1 reoperation or intervention within 30 days of surgery. Preoperative risk factors associated with drain placement included diabetes mellitus, a history of chronic obstructive pulmonary disease, and oxygen dependence. Smokers were slightly less likely to have a drain placed. There was no significant association with chronic steroid and immunosuppressant usage. Conclusion There is mounting data against drain placement during bariatric surgery. Prior studies using MBSAQIP data have shown an increased complication rate with drains, and our data set supports the idea that drains may increase complications after surgery. While no randomized prospective trials have been performed looking at drain usage in bariatric surgery, the growing retrospective data certainly inform against the regular use of drains.
The Impact of Virtual Crossmatch on Cold Ischemic Times and Outcomes Following Kidney Transplantation
Authors: Aslam Sadaf , Buggs Jacentha , Wyatt Kasey , Kumar Ambuj , Rogers Ebonie , Watson Robert 
Published: August 2020

Background Prolonged cold ischemic time (CIT) in deceased donor kidney transplantation (DDKT) has been associated with adverse graft outcomes. Virtual crossmatch (VXM) facilitates reliable prediction of crossmatch results based on the profile of human leukocyte antigen antibodies of the recipient and the donor in reduced time compared with a physical crossmatch (PXM). We hypothesized a shorter CIT since the implementation of the VXM in recipients of DDKT. Methods We conducted a retrospective cohort study of consecutive adult recipients of DDKT. The data were analyzed for differences in CIT before and after the implementation of VXM. Results After the exclusion of 59 recipients (age less than 18 years and/or CIT ≥ 20 hours), our study compared outcomes of 81 PXMs from February to June 2018 against 68 VXMs from February to June 2019. There were no statistical differences between groups based on donor age ( P = .09), donor type ( P = .38), kidney donor profile index ( P = .43), or delayed graft function ( P = .20). Recipients with VXM were older (58 vs 51 years , P = .002) and had a higher estimated post-transplant survival score (59% vs 46% , P = .01). The CIT was significantly lower for the VXM group ( P = .04). Conclusion Our study demonstrated a significantly shorter CIT with VXM in DDKT recipients. Our study was limited with small sample size, but the trend of increased graft survival with higher estimated post-transplant scores and older recipients is encouraging as the donor pool expands with marginal kidneys and national sharing.
Poor physical and mental health predicts prolonged grief disorder: A prospective, population-based cohort study on caregivers of patients at the end of life
Authors: Lenger Maja Krarup , Neergaard Mette Asbjoern , Guldin Mai-Britt , Nielsen Mette Kjaergaard 
Published: August 2020

Background: The health of caregivers can be affected during end-of-life caregiving. Previous cross-sectional studies have indicated an association between poor health status and prolonged grief disorder, but prospective studies are lacking. Aim: To describe physical and mental health status in caregivers of patients at the end of life, and to investigate whether caregivers’ health status during caregiving predict prolonged grief disorder. Design: A population-based prospective survey was conducted. Health status was measured in caregivers during caregiving (SF-36), and prolonged grief disorder was assessed 6 months after bereavement (Prolonged Grief-13). We calculated mean scores of health status and explored the association with prolonged grief disorder using logistic regression adjusted for age, gender and education. Setting/participants: The health in caregivers of patients granted drug reimbursement due to terminal illness in Denmark in 2012 was assessed during caregiving and 6 months after bereavement ( n = 2125). Results: The SF-36 subscale ‘role-physical’ concerning role limitations due to physical health, the ‘mental health’ component score, and all ‘mental health’ subscales showed significantly worse health in the participants than in the general population. Both poor physical health (adjusted OR: 1.05 (95% CI: 1.04–1.07)) and poor mental health (adjusted OR: 1.09 (95% CI: 1.07–1.11)) predicted prolonged grief disorder. Conclusion: Caregivers scored lower on one physical subscale and all mental health measures than the general population. Prolonged grief disorder was predicted by poor physical and mental health status before bereavement. Future research is needed on the use of health status in systematic assessment to identify caregivers in need of support.
Crude Oil Volatility Transmission Across Food Commodity Markets: A Multivariate BEKK-GARCH Approach
Authors: Thenmozhi M. , Maurya Shipra 
Published: August 2020

This study examines the time-varying price risk transmission in the nexus between crude oil and agricultural commodity prices in the context of non-grain-based biofuel producing country. Analysis of the short- and long-run dynamics of volatility in both spot and futures markets of maize, soybean and wheat and crude oil prices using the multivariate BEKK-GARCH model, indicate volatility spillover from wheat futures to crude oil futures in the short run and from crude oil futures to futures markets of maize, soybean and wheat in the long run. The spot market linkage of selected commodities is weaker compared to futures market, wherein maize spot volatility transmits to crude oil spot market in the longer period and no spillover between crude oil-food spot market is observed in the short run. The hedge ratios indicate that a dynamic hedging strategy is crucial for efficient risk management and the portfolio weights in futures market are more than the spot market. The results reveal that cross-market volatility spillover is more evident in the futures market, while own past conditional volatility is more significant in spot price discovery and risk transmission is evident among food commodities futures markets. JEL Codes: G13, G14, Q11, Q18, Q02
Assessing the Distinctive Contributions of Simulation & Gaming to the Literature, 1970-2019: A Bibliometric Review
Authors: Nguyen Uyen-Phuong , Hallinger Philip 
Published: August 2020

Background. Founded in 1970, Simulation & Gaming has emerged as the leading journal in this field of educational research. Given the centrality the journal’s influence, scholars have periodically reflected on the Journal’s contributions towards enhancing and refining both research and practice in educational simulation and gaming. Aims. This systematic review aimed to quantitatively document the distinctive contributions of S&G to research and practice on simulations and games over the past 50 years. The review sought to identify the geographic distribution of publications, influential authors and documents published in the Journal, the intellectual structure of the literature, and topics of recent interest. Method. The authors used the Scopus search engine to identify 1,427 research articles and reviews published in Simulation & Gaming from 1970 through the end of 2019. Bibliometric analyses included descriptive statistics, citation and co-citation and keyword co-occurrence analysis. Results. The review found that while the Journal has increased its geographical breadth impressively, the majority of Simulation & Gaming publications continue to be authored by scholars located in Anglo-American-European societies. The review also found that the Journal has become a prime venue for disseminating inter-disciplinary research on simulation and games. Nonetheless, business simulation/gaming surfaced as the dominant focus in the Journal’s content. Analysis of the intellectual structure of the knowledge base confirmed that the field is theoretically anchored in theories of social cognitive and experiential learning. Temporal keyword analysis identified active learning, game design, technology-enhanced simulations and games, and sustainability as topical clusters of recent interest to authors in Simulation & Gaming.
Earthquake response of the train–slab ballastless track–subgrade system: A shaking table test study
Authors: Cao Licong , Yang Changwei , Zhang Jianjing , Zeng Pengyi , Li Sifeng 
Published: August 2020

Earthquake is one of the major factors that provoke train derailment. To investigate dynamic responses of the train–slab ballastless track–subgrade system and derailment features of the train subjected to earthquake, a first large-scale shaking table test on this system was carried out in China. The loaded seismic wave is an earthquake wave of Zhengzhou Yellow River Bridge Site provided by the China Earthquake Administration. It was observed that the elevation of subgrade and embankment could magnify acceleration responses, and the transverse amplification effect of the elevation in soil was more pronounced than the vertical amplification effect. The acceleration response of a track slab was weaker than that of the top subgrade because of integrality and rigidity of the track slab. The bogie shows a shock-absorbing effect in the transverse direction. When the input amplitude was not larger than 0.14 g, the transverse and the vertical acceleration of the rail increased with rising earthquake amplitudes and fluctuated later. Meanwhile, the current stopping threshold for trains is conservative because the derailment factor was less than 0.8 and the peak lateral displacement of wheels was much smaller than the cross-sectional size of the rail model under a 0.12 g earthquake excitation. The current stopping threshold in codes could be reasonable in view of limited quantity and limited types of loaded earthquake in the test. The critical derailment condition of trains was 0.23 g when the Zhengzhou Yellow River Bridge Site earthquake was loaded, and the displacement analysis showed that it would be a great danger for train safety.