bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Portrait” of patients with idiopathic pulmonary hypertension and chronic thromboembolic pulmonary hypertension depending on comorbid status: current and prognosis features
Authors: Taran I. N. , Belevskaya A. A. , Valieva Z. S. , Saidova M. A. , Martynyuk T. V. 
Published: October 2020

Changing the "portrait" of patients with idiopathic pulmonary hypertension (IPH) and chronic thromboembolic pulmonary hypertension (CTPH) over the past decade suggests the need to develop models of phenotypes in patients with this cohort.The purpose of the study was to estimate the nature of the disease course and prognosis of patients with IPH and inoperable CTPH based on the formation of phenotypic groups depending on the comorbid status.Materials and Methods. Patients with IPH (n = 88) and inoperable CTPH (n = 38) aged 38.5 [28.5; 51] and 53.5 [41; 58] years respectively were enrolled in the study. 6-minute step test (6-MST) and spiroveloergometry, transthoracic echocardiography (EchoCG), catheterization of the right side of the heart was performed at the moment of diagnosis verification and in 13 [12; 20] months. All patients were divided into 5 groups according to comorbid status: Group 1 (n = 29) – patients with IPH/CTPH without comorbid pathology; Group 2 (n = 23) with body mass index (BMI) ≥ 25 kg/m2 ; Group 3 (n = 27) – with BMI ≥ 25 kg/m2 and dyslipidemia; Group 4 (n = 30) with hypertension, BMI ≥ 25 kg/m2 and dyslipidemia; Group 5 (n = 17) with the listed comorbid pathologies and carbohydrate metabolic disorders.Results. Initially more severe functional status was observed in patients of the 4th and 5th groups as compared to those in the 1st and 3rd groups. According to the data of the 3-dimensional EchoCG, in patients of the 4th and 5th groups a reliably more expressed increase in the volume of the right ventricle was revealed in comparison with such values in the 1st and 3rd groups. In IPH groups 1 and 3, the positive results of the vasoreactivity test (34.5% and 48.2%) were significantly more frequent in comparison with groups 4 (6.7%) and 5 (5.9%). The period from the diagnosis verification to adding the 2nd specific drug was significantly shorter in patients with IPH/CTPH of the 5th group compared to patients of the 3rd group. a high risk of lethal outcome after 13 [12; 30] months of treatment was significantly less frequently observed with IPH in Groups 1 and 3 as compared to Group 5.Conclusion. The combination of BMI ≥ 25 kg/m2, dyslipidemia, hypertension, as well as the additional presence of carbohydrate metabolism disorders is associated with a less favorable course of the disease in patients with IPH and inoperable CTPH.
Biomarkers of airways inflammation in patients with severe asthma in a real clinical practice
Authors: Sergeeva G. R. , Emel'yanov A. V. , Leshenkova E. V. , Znakhurenko A. A. 
Published: October 2020

Severe asthma is a heterogeneous disease consisting of several endotypes and phenotypes diagnosed due to different biomarkers. Frequency of different endotypes and phenotypes in real clinical practice needs further investigation.The aim of this study was to assess biomarkers of T2-inflammation in patients with severe asthma in a single secondary care center.Methods. We examined 96 adult outpatients (34% male) with severe asthma. Data collected included demographics, smoking history, asthma exacerbations during previous 12 months, medication use, comorbidities. Lung function tests were assessed by using the Spirograph 2120 (Vitalograph, Great Britain). Blood eosinophils (Eos) were measured by automatic haemoanalyser. Atopic status was determined by positive skin prick-test (> 3 mm) and/or serum specific IgE to common inhalant allergens. Serum total IgE levels were assessed by immunofluorescence assay. FeNO was measured by a chemiluminescence analyzer (Model LR4000; Logan Research, Rochester, UK). Presence of allergy, need for regular oral steroid use, blood Eos ≥ 150 cell/μl and FeNO ≥ 20 ppb were considered as markers of T2-driven inflammation. Asthma control and quality of life were assessed by using Russian versions of ACQ-5 and St. George's Respiratory Questionnaire (SGRQ). Statistical analyses were performed with Statistica Ver. 10.0 (StatSoft, Inc., USA).Results. The majority of patients with severe asthma (93%) have at least one or more elevated markers (presence of allergy, need for regular oral steroid use, Eos ≥ 150 cell/μl or FeNO ≥ 20 ppb) of T2-inflammation. Biomarkers levels did not differ in non-steroid-dependent and steroid-dependent patients. The most frequent markers were allergy and blood Eos ≥ 150 cell/μl. Two or more elevated biomarkers were revealed in 72% of patients.Conclusion. The majority of patients with severe asthma in real clinical practice have signs of T2-inflammation. It seems that many severe asthmatics have indications for prescription of biological and can be treated by more than one of monoclonal antibodies against major cytokines of T2-inflammation.
An environmental imperative in the development of the national economy: increasing the potential of microalgae
Authors: Melikhov V. V. , Medvedeva L. N. , Frolova M. V. 
Published: October 2020

Aim. To study the methodological basis for increasing the potential of applications of microalgae in the national economy, as one of the environmental imperatives in the development of new natural resources for future generations.Materials and Methods. The research was conducted on the basis of content analysis of Russian and foreign scientific publications and materials obtained in the course of expeditions and experimental and sociological research. The clustercognitive approach and economic-mathematical modeling were used for a more complete exposition of the topic.Discussion. According to imperatives of the green economy, environmental technologies will become leading factors in the development of the world economy. The most important incentive for entrepreneurs in the environmental market will be growing the demand of consumers and of governments. Promising areas include the use of microalgae in the production of foods beneficial to human health, feed additives in animal husbandry, poultry farming and fish farming, substances for improving water quality in reservoirs and the clean-up of oil spills. The issue of increasing the potential of microalgae at the regional level on the basis of a cognitive cluster approach is most relevant. The procurement of live microalgae biomass in amounts necessary to thoroughly supply world and national markets remains challenging in both technological and technical terms. Economic and mathematical models and sociological research, as well as the opinions of experts, allow us to justify business decisions in opening microalgae production facilities. Microalgae Chlorella vulgaris and Spirulina platensis present promising prospects for entrepreneurial investment due to the high value of their metabolites.Conclusion. The increase in production and applications of microalgae is of major strategic potential in the development of the national economy, as the manufacture of bio-products and immune-stimulating drugs increases every year in response to climate change, pandemics, environmental pollution, food shortages and difficulties in accessing clean water. It is necessary to adopt legislative and regulatory instruments and organizational measures aimed at stimulating the investment of funding entities and entrepreneurs in the production of microalgae products in various sectors of the economy. International collaborations, industrial enterprises and space agencies (e.g. Roscosmos and NASA) are actively conducting research into the use of microalgae for the processing of organic waste in human living facilities in space as a source of both oxygen and food. The issue of creating clusters and applying mechanisms of public-private partnership aimed at increasing the profitability of bio-product manufacture from microalgae in various industries and sectors of the economy at the macro-and meso-level remains relevant.
Limits for <i>Coregonus migratorius</i> (Georgi, 1775) catches and likely ecological effects
Authors: Anoshko P. N. , Makarov M. M. , Zorkaltsev V. I. , Denikina N. N. , Dzyuba E. V. 
Published: October 2020

Aim. This study aims to discuss the validity of introducing restrictions on the catch of Coregonus migratorius (Georgi, 1775) with a forecast of the likely environmental consequences of doing so.Discussion. We show the results of the analysis of the assessment of the state of C. migratorius stocks and the reasons for their decline. We indicate that the biostatistical and hydroacoustical methods for estimating fish numbers, which are traditionally used to substantiate allowable catches, have some disadvantages and limitations. We consider unrecorded catches and unfavourable natural and climatic environmental factors to be reasons for the decline in C. migratorius stocks. We discuss ecological and anthropogenic factors of changes in stocks of this commercially important species for the region. We show the anticipated ecological effects of currently established limits.Conclusion. The results of changes in the modelling of the number and age composition of fish with different protection strategies indicate that maintaining a low level of replenishment stock the limits would not increase commercial stocks of C. migratorius. Restrictions imposed on the commercial and amateur fishing would significantly increase environmental risks through increase of poaching (including during the spawning period) as well as as a consequence of amateur fishing of other commercially valuable fish species.
Estimation of natural reproduction efficiency of semi-anadromous and river fish species in inland water bodies of the Republic of Dagestan, Russia
Authors: Abdusamadov A. S. , Akhmaev E. A. , Latunov A. A. , Abdusamadov T. A. , Butaeva A. K. , Guseinova S. A. 
Published: October 2020

Aim. Estimation of the natural reproduction efficiency and patterns of formation of fish stocks.Material and Methods. Collection of material was carried out in 2010-2019 in inland water bodies in Dagestan and its shallow Caspian Sea coastal zone. Estimation of the number of juveniles in rivers and canals was carried out using ichthyoplankton cone seines. Fry seines were used to count juveniles of fish in water bodies and in the coastal area. 470 samples of juveniles were collected and 5640 juveniles were analysed. The collection and processing of materials were carried out according to generally accepted methods.Results. The main environmental factors determining the productivity of fish juveniles in the study area in the long-term have been identified. During the observation period, juvenile fish of 15 species were recorded in spawning grounds of inland water bodies. Roach, bream, carp, crucian carp, rudd and vimba bream dominate. In terms of numbers, roach juveniles predominate: their relative proportion being 31.02% with an increase from 27.1% in 2010 to 35.4% in 2018.The second place was occupied by bream juveniles, whose average relative proportion was 12.1%. The third place was occupied by carp juveniles with an average proportion of 9%. Juvenile zander, catfish, pike and kutum are relatively low in abundance from 2 to 4%. The yield of juvenile fish in 2010-2019 decreased 1.7 times compared to 1990-1995.Conclusion. It was established that a decrease in the number of juvenile fishes occurs under the influence of unfavorable environmental factors: decrease in sea level; reduction in spawning areas; the shallowing and silting of migration routes due to the lack of a stable water supply. Measures are proposed to improve the living conditions of aquatic biological resources, aimed at increasing the efficiency of their natural reproduction.
Catalogue of bat viruses (2020)
Authors: Shchelkanov M. Yu. , Dunaeva M. N. , Moskvina T. V. , Voronova A. N. , Kononova Yu. V. , Vorobyeva V. V. , Galkina I. V. , Yanovich V. A. , Gadzhiev A. A. , Shestopalov A. M. 
Published: October 2020

Aim. Aim of this the research presented in this article is to analyze the representation of bat (Chiroptera) viruses in various taxa of the Virae kingdom.Discussion. Currently, 260 viruses are associated with bats belonging to 19 orders, 28 families (9 DNA‐containing and 19 RNA‐containing) and 61 genera (18 DNA‐containing and 43 RNA‐containing). This number includes viruses annotated by the International Committee on the Taxonomy of Viruses (excluding synonymous species) for which the taxonomic status has been verified by sequencing subgenomic or full‐genomic nucleotide sequences. A large number of unidentified strains from bats are noteworthy – they apparently contain many future prototype viruses for new taxa.Conclusion. The data presented in this article will undoubtedly be expanded in the nearest future. This is due to the need to improve the system for prevention of dangerous epidemic and pandemic situations primarily by increasing priority attention on bat viruses. Therefore, the catalogue of bat viruses, known as of mid‐2020, presented in this paper could be considered as a kind of "starting point" for future research in this area.
Assessment of bioclimatic comfort of the Krasnodar Territory, Russia through the application of GIS‐technologies
Authors: Kuzyakina M. V. , Gura D. A. 
Published: October 2020

Aim. To determine the most and least comfortable zones of the Krasnodar Territory by month.Material and Methods. The bioclimatic indices studied take into account the combined influences of temperature, wind speed, relative humidity, atmospheric pressure and solar radiation in various combinations. A geoinformation analysis of the following bioclimatic indices was carried out: effective temperature, equivalent-effective temperature, bioclimatically active temperature, radiation equivalent-effective temperature, and a complex indicator of the level of pathogenic effects of weather in the Krasnodar Territory. The weather pathogenicity index is the only index in the article that takes into account atmospheric pressure. The study also added an assessment of the severity of winter. The following indices of “cold stress” were calculated and mapped: integrated cooling index (frostbite), Bodman climate severity index, Siple-Passel cooling index and wind-cold index.Results. The Krasnodar Territory was divided into 4 comfort zones: Azov-Black Sea, Black Sea, South-Eastern Foothills and Continental.Conclusions. Comfortable months have been established for living in the Krasnodar Territory as a whole, and areas of the Krasnodar Territory favourable for life at any time of the year. The severity of winter in the Krasnodar Territory as shown by the analysis is closely correlated with wind strength.
Current level of oil hydrocarbons in Russian coastal waters of the Black Sea and and Azov Sea
Authors: Mironov O. A. , Mironov O. G. 
Published: October 2020

Aim. Currently, oil pollution remains one of the primary pollutants of the marine environment. This is especially true for the Black Sea and Azov Sea which experience significant anthropogenic pressure. The study presents the results of two-year monitoring studies of the content of oil hydrocarbons in the surface and bottom horizons of the coastal waters of the Azov-Black Sea regions of Russia.Materials and Methods. The determination of oil hydrocarbons was conducted by infrared spectrometry using a FSM-1201 Fourier spectrophotometer with preliminary transmission of the extracts through a chromatographic column with aluminum oxide. The work was carried out as part of five scientific expeditions (93th, 96th, 100th, 102nd and 105th) of the research vessel, Professor Vodyanitsky, in 2017 and 2018.Results. The general environmental status for this pollutant is characterized as stable, despite in some cases being 3 to 4 times in excess of established standards (MPC). Separate foci of localized oil pollution have been identified and vulnerable areas of the sea coast of southern Russia have been identified. An excess content of petroleum hydrocarbons in the surface layer compared to the bottom layer was noted, which indicates a surface path of entry of petroleum products into sea water.Conclusion. Currently, the coastal waters of the western part of Crimea are most affected by oil, primarily associated with the runoff of European rivers and the peculiarities of the marine hydrological regime, including the Kerch Strait, an area of heavy shipping traffic. The Caucasian coast is less affected by oil pollution than the Crimean. Despite the fact that currently the content of oil hydrocarbons in sea water is far from the quantities dangerous to humans and aquatic organisms, monitoring of this indicator is vital due to the increasing anthropogenic pressure on the recreational zones of the Crimean and Caucasian coasts of the Russian Federation.
Studying and mapping the landscapes of the Sareptsky peninsula in Lower Volga, Russia
Authors: Kosheleva O. Yu. , Shinkarenko S. S. , Solodovnikov D. A. , Omarov R. S. 
Published: October 2020

Aim. Islands and peninsulas in the Volga are of great environmental and recreational importance for the Volgograd agglomeration. Identifying the current state of geocomplexes in the Sareptsky peninsula allow us to assess the developmental trends of the floodplain ecosystems in the Lower Volga, which are under intense economic pressures.Material and Methods. The mapping was done by decoding Sentinel-2 satellite imagery and drawing landscape contours using the QGIS program. Field work was carried out in June 2019. Seven test plots were laid out. Inventory of forest plantations was undertaken with distribution of trees according to condition and a geobotanical description of the grass stand was done.Results. The Sareptsky peninsula was revealed to be an island by origin that was artificially attached to the native coast. The landscape structure of the peninsula includes 6 natural-anthropogenic complexes, of which the largest area (62.9%) is occupied by natural floodplain forest and cultivated forest. 13.9% is occupied by water meadows of the central floodplain, 8.0% by aquatic complexes of inland water bodies, 7.3% by anthropogenically transformed areas (settlements and industrial lands, roads and hydraulic structures), 5.1% by open areas of fresh-water floodplain and 2.8% by beach shoals of the river channel floodplain. The signs were revealed of a negative effect on the Volga through the regulation of its flow from desiccation of poplars and meagre species composition of meadow vegetation. It was established that the territory of the peninsula is exposed to a small extent by recreational activities.Conclusion. Landscape-ecological studies made in the Sareptsky peninsula allowed the assessment of the current state of forest and meadow ecosystems, the identification of the principal factors involved in the deterioration of their ecological status and the articulation of a better way to optimize nature management.
Analyzing Information about a Hajj Pilgrimage in Indonesia in the Rare Newspaper Collection of The National Library of Indonesia
Authors: Supratman Frial Ramadhan 
Published: October 2020

Background of the study: Indonesia is a country whose the largest number of Muslims in the world. Every year, many Indonesian Muslims come to Mecca to perform hajj pilgrimage. In order to improve pilgrimage activity, Government and society need exact information about that. The librarian can take an important role in order to supply information about hajj pilgrimage.Purpose: The aim of research is explaining description and information about Indonesian hajj pilgrims through a collection of rare newspapers in the National Library of Indonesia.Method: The method used in this research is a descriptive research method. Author analyzes twenty two newspapers in National Library. Having been analyzed, the information obtained is interpreted by historical approach.Findings: The result of this research is that the author finds out 22 newspapers which contains information of hajj pilgrims. The information is qualitative data on the amount of hajj pilgrims and ships, the expense of hajj pilgrimage, the experience of hajj pilgrims, the problem faced by hajj pilgrims and government policy in controlling hajj pilgrims.Conclusion: In this paper, the author argues that rare newspaper collection contains many information about the activity of the hajj pilgrimage during Dutch colonial period.
Mitochondrial Dysfunction Accelerates Ageing
Authors: Schroth Johannes , Henson Sian M. 
Published: October 2020

Abstract
We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the detrimental effects of age-related disease.
Management and Outcome of a Complex Medial Tibial Plateau Fracture
Authors: Kumar Deepak , Sodavarapu Praveen , Aggarwal Aditya , Hooda Aman , Sajid Mohammad 
Published: October 2020

Case:
A 26-year-old patient who had a road traffic accident sustained a complex knee injury, which resulted in a comminuted fracture of the medial tibial plateau, along with undisplaced lateral collateral ligament (LCL) avulsion that was managed surgically with rim plating, resulting in a good outcome after 1-year follow-up

Conclusion:
The authors present a rare case of a combination of axial loading and varus injury to the knee, which caused splaying of the medial tibial plateau with an undisplaced LCL avulsion, managed with single rim plating, which is a relatively new method of fixation that obviated the need for 2 separate implants, with good functional outcome.
Deep-Learning-Based Vuggy Facies Identification from Borehole Images
Authors: Jiang Jiajun , Xu Rui , James Scott C. , Xu Chicheng 
Published: October 2020

SummaryIdentification of vuggy intervals and understanding their connectivity are critical for predicting carbonate reservoir performance. Although core samples and conventional well logs have been traditionally used to classify vuggy facies, this process is labor intensive and often suffers from data inadequacies. Recently, convolutional neural network (CNN) algorithms have approached human-level performance at multiimage classification and identification tasks. In this study, CNNs were trained to identify vuggy facies from a well in the Arbuckle Group in Kansas, USA. Borehole-resistivity images were preprocessed into half-foot intervals; this complete data set was culled by removing poor-quality images to generate a cleaned data set for comparison. Core descriptions along with conventional gamma ray, neutron/density porosity, photoelectric factor (PEF), and nuclear magnetic resonance (NMR) T2 data were used to label these data sets for supervised learning. Hyperparameters defining the CNN network size (numbers of convolutional layers/filters and the numbers of fully connected layers/neurons) and minimize overfitting (dropout rates, patience, and minimum delta) were optimized. The median losses and accuracies from five Monte Carlo realizations of each hyperparameter combination were the metrics defining CNN performance. After hyperparameter optimization, median accuracy for vuggy/nonvuggy facies classification was 0.847 for the cleaned data set (0.813 for the complete data set). This study demonstrated the effectiveness of using microresistivity image logs in a CNN to classify facies as either vuggy or nonvuggy, while highlighting the importance of data quality control. This effort lays the foundation for developing CNNs to segment images to estimate vuggy porosity.