bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective observational study comparing somatosensory amplification in fibromyalgia, chronic pain, psychiatric disorders and healthy subjects
Authors: Ciaramella Antonella , Silvestri Simona , Pozzolini Valentino , Federici Martina , Carli Giancarlo 
Published: November 2020

Abstract

Objectives
Somatosensory amplification (SA) has been described as an important feature of somatoform disorders, and an “amplifying somatic style” has been reported as a negative connotation of body perception. As widespread pain (WSP) in fibromyalgia (FM) is due to a central sensitization (CS) rather than organic alterations, there has been discussion as to whether FM is equivalent to or distinct from somatization disorder (SD). Assuming SD and FM are two distinct entities, an increase in somatic amplification should be expected only in subjects who have SD, regardless of the type of pain they experience. Purpose of the study was to explore the magnitude of SA in FM, and whether this depends on the association with SD.

Methods
FM (n=159) other forms of chronic pain (OCP, n=582), psychiatric (Psy, n=53) and healthy (H, n=55) subjects were investigated using the Somatosensory Amplification Scale (SSAS), Illness Behavior Questionnaire, (IBQ), Italian Pain Questionnaire (IPQ), and Cold Pressor Test (CPT) in a retrospective observational study.

Results
FM subjects displayed higher SSAS scores than the other groups. High SSAS score was associated with FM (OR=8.39; 95%CI: 5.43–12.46) but not OCP. Although FM has the highest prevalence of SD (x2=14.07; p=.007), high SSAS scores were associated with SD in OCP but not in FM.

Conclusions
Unlike in OCP, in FM high SSAS scores were independent of the presence of SD. From a biopsychosocial perspective, SSAS may be a factor associated with the onset of FM.
Testing constant cross-sectional dependence with time-varying marginal distributions in parametric models
Authors: Kaldorf Matthias , Wied Dominik 
Published: November 2020

Abstract
This paper proposes parametric two-step procedures for assessing the stability of cross-sectional dependency measures in the presence of potential breaks in the marginal distributions. The procedures are based on formerly proposed sup-LR tests in which restricted and unrestricted likelihood functions are compared with each other. First, we show theoretically that standard asymptotics do not hold in this situation. We propose a suitable bootstrap scheme and derive test statistics in different commonly used settings. The properties of the test statistics and precision of the associated change-point estimator are analysed and compared with existing non-parametric methods in various Monte Carlo simulations. These studies reveal advantages in test power for higher-dimensional data and an almost uniform superiority of the sup-LR test in terms of precision of the change-point estimator. We then apply this method to equity returns of European banks during the financial crisis of 2008.
An overlooked situation in the interpretation of serum thyroglobulin level in a papillary thyroid cancer patient
Authors: Sirin Fevziye Burcu , Korkmaz Hakan 
Published: November 2020

Abstract
In the present study we report a case of thyroglobulin (TGB) measurement interference in a total thyroidectomized and radio-ablated 61-year old woman with papillary thyroid cancer. We investigated possible interference in the measurement of TGB due to discordant TGB in relation to clinical condition during the follow-up period. Serum TGB was measured with the chemiluminescence method using Beckman Coulter Unicel DxI 800 instrument. To investigate possible interference in TGB measurement serial dilutions, polyethylene glycol precipitation (PEG), treatment with heterophile blocking tube (HBT), rheumatoid factor level determination and retesting of TGB with an alternative method were performed. Serial dilutions of the serum sample revealed linearity but a remarkable decrease in TGB in the patient’s serum samples post PEG and post HBT treatments. Also, TGB results under functional sensitivity level obtained with a different method suggested that TGB interference developed due to heterophile antibody presence in the serum sample. The patient had unnecessarily undergone expensive imaging techniques, and invasive procedures such as lymph node fine needle aspiration biopsy, before the analytical interference was suspected by the clinician. This report illustrates the importance of early communication and close collaboration between clinicians and laboratorians in order to avoid unnecessary clinical intervention.
Value of blood IFN-I levels in COVID-19 management
Authors: Arslan Burak , Dinçel Aylin Sepici 
Published: November 2020

Abstract
Coronavirus disease 2019 (COVID-19) which is a respiratory system disease has created inevitable pandemic. In the course of disease; the uncontrolled inflammatory response may cause tissue damage. 80–90% of patients undergo mild-to-moderate disease symptoms, the rest of the patients proceeds to critical or severe disease. Type I Interferons (IFN–I) are crucial immune mediators in order to host responses to viral infection likewise those are major components of the innate immune system moreover serve as critical antiviral molecules. IFN-I are within the first cytokines secreted during a viral infection. Until now, IFN-I response has been evaluated in patients with COVID-19 in a few publications and its contribution to the viral load control and inflammation is very little known. In those studies, the researchers have found that IFN-I deficiency which characterized by no IFN- β and low IFN- α production and activity is a hallmark of severe and critical COVID-19. Until recently, measurement of circulating serum levels of IFN-α have been limited owing to the limits of conventional immunoassay technology. Limit of detection problems of immunoassays has started to figure out thanks to SIMOA. On the top of that, generally the platforms that use SIMOA technology is 10–100 fold more sensitive than most conventional immunoassays. We should strive to do research that includes IFN-I with using platforms that include SIMOA technology, especially in severe COVID-19.
Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling
Authors: Cheng Jiang , Wang Guowei , Zhang Na , Li Fang , Shi Lina , Li Haining 
Published: November 2020

Abstract

Background:
Alzheimer’s disease (AD) is an ultimately fatal, degenerative brain disease in the elderly people. In the current work, we assessed the defensive capability of isovitexin (IVX) through an intracerebroventricular injection of streptozotocin (STZ)-induced AD mouse model.

Methods:
Mice were separated into four cohorts: sham-operated control mice; STZ-intoxicated Alzheimer’s mice; IVX cohort, IVX + STZ; and Ant-107 cohort, antagomiR-107 + IVX/STZ as in the IVX cohort.

Results:
The outcomes indicated that IVX administration ameliorated spatial memory loss and blunted a cascade of neuro-noxious episodes – including increased amyloid-beta (Aβ) and degraded myelin basic protein burden, neuroinflammation (represented by elevated caspase-1, TNF-α and IL-6 levels) and autophagic dysfunction (represented by altered LC3-II, Atg7 and beclin-1 expressions) – via the inhibition of PI3K/Akt/mTOR signalling axis. We considered the question of whether the epigenetic role of microRNA-107 (miR-107) has any impact on these events, by using antagomiR-107.

Conclusion:
This probing underscored that miR-107 could be a pivotal regulatory button in the activation of molecular signals linked with the beneficial autophagic process and anti-inflammatory activities in relation to IVX treatment. Hence, this report exemplifies that IVX could guard against Aβ toxicity and serve as an effectual treatment for patients afflicted with AD.
Theory of Religion and Historical Research. A Critical Realist Perspective on the Study of Religion as an Empirical Discipline
Authors: Seiwert Hubert 
Published: November 2020

AbstractThe article discusses the connection between theory formation and historical research in the study of religion. It presupposes that the study of religion is conceived of as an empirical discipline. The empirical basis of theories is provided primarily by historical research, including research in the very recent past, that is, the present time. Research in the history of religions, therefore, is an indispensable part of the study of religion. However, in recent discussions on the methods, aims, and theoretical presuppositions of the discipline, research in the history of religions largely is ignored. To shed some light on this blind spot, the article builds on the philosophy of science of Critical Realism. While the first part deals with the role of historical research in theoretical discourses of the discipline, the second part explains fundamental ontological and epistemological positions of Critical Realism and their implications for empirical research. On this basis, some methodological problems of theory formation in the study of religion are discussed in the third part. In particular, it is argued that it is impossible to validate empirically theories of religion that aim to explain what religion is. The concluding part sketches ways of theory formation in the study of religion that does not take religion as the explanandum but as the theoretical perspective that guides research.
From the Ritter pile to the aluminum ion battery – Peter Paufler’s academic genealogy
Authors: Leisegang Tilmann , Levin Aleksandr A. , Kupsch Andreas 
Published: November 2020

AbstractThis article highlights Peter Paufler’s academic genealogy on the occasion of his 80th birthday. We describe the academic background since 1776, which covers 11 generations of scientists: Ritter, Ørsted, Han-steen, Keilhau, Kjerulf, Brøgger, Goldschmidt, Schulze, Paufler, Meyer, and Leisegang. The biographies of these scientists are described in spotlight character and references to scientists such as Dehlinger, Ewald, Glocker, Röntgen, Vegard, Weiss, and Werner are given. A path is drawn that begins in the Romanticism with electrochemistry and the invention of what is probably the first accumulator. It leads through the industrialization and the modern geology, mineralogy, and crystallography to crystal chemistry, metal and crystal physics and eventually returns to electrochemistry and the aluminum-ion accumulator in the era of the energy transition. The academic genealogy exhibits one path of how crystallography develops and specializes over three centuries and how it contributes to the understanding of the genesis of the Earth and the Universe, the exploration of raw materials, and the development of modern materials and products during the industrialization and for the energy transition today. It is particularly characterized by the fields of physics and magnetism, X-ray analysis, and rare-earth compounds and has strong links to the scientific landscape of Germany (Freiberg) and Scandinavia, especially Norway (Oslo), as well as to Russia (Moscow, Samara, St. Petersburg). The article aims at contributing to the history of science, especially to the development of crystallography, which is the essential part of thestructural scienceproposed by Peter Paufler.
Pt3Ni/C and Pt3Co/C cathodes as electrocatalysts for use in oxygen sensors and proton exchange membrane fuel cells
Authors: Weng Yu-Ching , Ho Cheng-Jen , Chiao Hui-Hsuan , Wang Chen-Hao 
Published: November 2020

Abstract
The composites Pt3Ni/C and Pt3Co/C are electrocatalysts for oxygen reduction reactions (ORRs). This study compares the electrocatalytic activity of these electrodes that are used to detect oxygen, and determines their suitability for use in proton exchange membrane fuel cells (PEMFCs). Chemical reduction is used to produce the Pt3Ni/C and Pt3Co/C electrocatalysts. The particle size, elemental composition and crystallinity of the intermetallic electrocatalysts are determined using transmission electron microscopy (TEM) and an energy-dispersive spectrometer (EDX). The ORR activity of the Pt3Ni/C and Pt3Co/C electrocatalysts is determined using cyclic voltammetry (CV), a polarization curve (PC) and a rotating disk electrode (RDE). The Pt3Ni/C electrode registers a greater current for the ORR as compared to the Pt3Co/C electrode. Both electrodes exhibit a linear relationship between response current and oxygen concentration in the detection range from 100 to 1000 ppm. The Pt3Ni/C electrode exhibits a significant sensitivity to oxygen up to 13.4 μA ppm−1 cm−2. A membrane electrode assembly (MEA) that is produced using Pt3Ni/C as a cathodic electrocatalyst in a single PEMFC generates a maximum power density of 1097 mW cm−2.
Synergistic antibacterial combination of Lavandula latifolia Medik. essential oil with camphor
Authors: Karaca Nursenem , Şener Görkem , Demirci Betül , Demirci Fatih 
Published: November 2020

Abstract
Combination of various compounds and essential oils for pharmaceutical formulations withdraw attention. In this present study, it was aimed to evaluate the in vitro potential synergistic antibacterial effect of Lavandula latifolia (spike lavender) essential oil with camphor by using the checkerboard method against the human pathogens; Staphylococcus aureus and Listeria monocytogenes. Pharmacopoeia quality L. latifolia essential oil and racemic camphor were analyzed and verified by GC-FID and GC/MS, simultaneously. In vitro antibacterial activity of essential oil and camphor (MIC range: 0.16–20 mg/mL) and standard antimicrobial clarithromycin (MIC range: 0.125–16 μg/mL) were carried out by broth microdilution against S. aureus and L. monocytogenes standard strains, respectively. Resulting antibacterial effects were evaluated for their fractional inhibitory concentrations (FICs) as antagonistic, additive and synergistic effects. The analytical results showed that the major component of essential oil was linalool (45.2%) and 1,8-cineole (25.6%). Antibacterial effects of essential oil were determined as MIC 1.25–5 mg/mL. As a result of the experiments, L. latifolia essential oil–camphor combinations were identified as “synergistic (FIC ≤ 0.5), and additive (0.5 < FIC ≤ 1)” in the respective combinations, suggesting further evaluation for formulations for potential antimicrobial applications in food and pharmaceuticals.
Absolute configuration of tetrandrine and isotetrandrine influences their anti-proliferation effects in human T cells via different regulation of NF-κB
Authors: Xu Wencheng , Kusano Junichi , Chen Shuhe , Yamamoto Ryusei , Matsuda Hiroto , Hara Yoshikazu , Fujii Yoshiaki , Hayashi Seiichi , Tanaka Sachiko , Sugiyama Kentaro , Yamada Haruki , Hirano Toshihiko 
Published: November 2020

Abstract
Natural compound tetrandrine was reported to inhibit the proliferation of T cells by inhibiting activation of NF-κB. Chemically, isotetrandrine differs from tetrandrine only in the stereochemistry at the chiral centers. The present study aimed to compare their anti-proliferation effects on human T cells with a focus on NF-κB. The IC50 values of tetrandrine against MOLT-4 cells, MOLT-4/DNR cells, and concanavalin A-activated peripheral blood mononuclear cells of healthy subjects and dialysis patients were 4.43 ± 0.22, 3.62 ± 0.22, 1.91 ± 0.22 and 3.03 ± 0.28 μM, respectively. Whereas, the IC50 values of isotetrandrine against the above immune cells were 2.19 ± 0.27, 2.28 ± 0.33, 1.29 ± 0.14 and 1.55 ± 0.26 μM, respectively. The inhibitory effect of isotetrandrine against the proliferation of T cells was stronger than that of tetrandrine significantly (p < 0.05). Molecular mechanism investigation showed that 10 μM of isotetrandrine largely decreased the expression of p-NF-κB and NF-κB in both MOLT-4 and MOLT-4/DNR T cells (p < 0.05), whereas 10 μM of tetrandrine slightly inhibited the phosphorylation of p-NF-κB with little influence on the expression of NF-κB. Taken together, absolute configurations of tetrandrine and isotetrandrine are suggested to influence on their anti-proliferation effects in human T cells via different regulation of NF-κB.
Pengembangan Penilaian Autentik Pembelajaran Teks Dialog Bahasa Jawa Kelas VII
Authors: Meliana Siti , Sudi Utami Esti , Sukoyo Joko 
Published: November 2020

Assessment is once of process study which is conducted to measure students by basic competency. Lack of reference to teachers for assessment dialog text make obstacles for giving assessment to students. This limitation made basic must be need assessment of development technique where can helping teachers to give an assessment. This research has a purpose to develop learning instrument assessment dialog of text Javanese Language. This research has used research and development methods, with five-stage of research, include identity potency and problem, data collection, design product, validation design, and then revision of the design. Collection data used by interviews andquestionnaires instruments. Result of this research in the form of authentic assessment learning dialog text Javanese Language. The assessment of instruments is a question of multiple-choice, task, work method/practice, and product. Result of validation has to show acquisition average score at the question of multiple choice 11,72 (enough) from evaluation expert and score 12,11 (good) from teacher expert, and while the average score assessment of tasking, work method/practice, and product 3,7 (good) from expert and 3,1 (enough) 2 from teachers. Repaired has done on the selection of diction, sentence structure, and repair choice answers.
High-Density Linkage Maps Based on Genotyping-by-Sequencing (GBS) Confirm a Chromosome-Level Genome Assembly and Reveal Variation in Recombination Rate for the Pacific OysterCrassostrea gigas
Authors: Yin Xiaoshen , Arias-Pérez Alberto , Kitapci Tevfik Hamdi , Hedgecock Dennis 
Published: November 2020

AbstractStudies of linkage and linkage mapping have advanced genetic and biological knowledge for over 100 years. In addition to their growing role, today, in mapping phenotypes to genotypes, dense linkage maps can help to validate genome assemblies. Previously, we showed that 40% of scaffolds in the first genome assembly for the Pacific oyster Crassostrea gigas were chimeric, containing single nucleotide polymorphisms (SNPs) mapping to different linkage groups. Here, we merge 14 linkage maps constructed of SNPs generated from genotyping-by-sequencing (GBS) methods with five, previously constructed linkage maps, to create a compendium of nearly 69 thousand SNPs mapped with high confidence. We use this compendium to assess a recently available, chromosome-level assembly of the C. gigas genome, mapping SNPs in 275 of 301 contigs and comparing the ordering of these contigs, by linkage, to their assembly by Hi-C sequencing methods. We find that, while 26% of contigs contain chimeric blocks of SNPs, i.e., adjacent SNPs mapping to different linkage groups than the majority of SNPs in their contig, these apparent misassemblies amount to only 0.08% of the genome sequence. Furthermore, nearly 90% of 275 contigs mapped by linkage and sequencing are assembled identically; inconsistencies between the two assemblies for the remaining 10% of contigs appear to result from insufficient linkage information. Thus, our compilation of linkage maps strongly supports this chromosome-level assembly of the oyster genome. Finally, we use this assembly to estimate, for the first time in a Lophotrochozoan, genome-wide recombination rates and causes of variation in this fundamental process.
Pegada de carbono do amendoim: um estudo bibliométrico
Authors: Dalpian Aline Schneiders Martins , De Albuquerque Elaine Bento , Rodrigues José de Souza 
Published: November 2020

O termo “pegada de carbono” para os produtos se refere à massa de gases de efeito estufa (GEE) emitida devido à produção, uso e descarte de um produto. Assim, estudos sobre pegada de carbono de produtos contabilizam as emissões provenientes de um conjunto de processos relacionados ao ciclo de vida de um produto (PANDEY et al., 2011). Este trabalho analisa de forma bibliométrica estudos feitos sobre a pegada de carbono na produção e nos produtos do amendoim. Para tanto, foi realizada uma pesquisa qualitativa em artigos selecionados, onde se observou questões mais prementes da sustentabilidade, no que se refere ao esgotamento dos recursos de energia fóssil e a emissão de gases de efeito estufa na atmosfera (GEE), como dióxido de carbono (CO2). O presente estudo teve como objetivo encontrar na base científica SCOPUS estudos sobre a pegada de carbono do amendoim. e com a pesquisa bibliométrica citar estudos sobre a pegada de carbono na produção do amendoim. Na base SCOPUS, com o uso das palavras chave peanut (amendoim), carbono e foodprint (pegada de carbono), foram encontradas 20 publicações e selecionadas 6 para discussão. Os resultados mostram que é incipiente os estudos sobre o tema, e que apenas 20 publicações foram feitas nos últimos 10 anos, denotando mais investigação sobre o impacto dos gases efeito estufa na produção do amendoim.
A Comparative Produced Water Management Decision Making WorkFlow: MSEEL Case Study
Authors: Dickerson Clayton , Mirabolghasemi Maryam 
Published: November 2020

Abstract
Currently the most common practice for produced water management is disposal through injection into Class IID wells with minimal treatment. This option is costly and risky, especially for wells that are located far from the nearest disposal well. Under these circumstances, treating the produced water for reuse becomes an appealing option. This study investigates disposal and treatment options in detail to determine the economic feasibility of each treatment option compared to the available disposal option.
We used water production and well data from Marcellus Shale Energy and Environment Laboratory (MSEEL) to build a case study for the assessment of disposal, and membrane desalination options. We collected other necessary information such as disposal well location and desalination parameters from the Environmental Protection Agency and previously published papers. We investigated the following high salinity water treatment methods: high pressure reverse osmosis (HPRO), electrodialysis (ED), and direct contact membrane desalination (DCMD).
Under the assumptions of our study, we found that disposal costs less than HPRO and DCMD. ED, on the other hand, is less expensive than disposal and provides more flexibility in terms of the quality of the produced permeate. Our results also show that if the disposal well is farther than 100 miles from the MSEEL well pad, DCMD becomes more cost-efficient than disposal. As the salinity of the MSEEL produced water drops, the cost of HPRO and ED also decreases.
Produced water treatment reduces truck traffic and lowers the spill risk, emissions, and road wear. However, treatment options must be economically evaluated for each well to determine their feasibility. Our findings may serve as a guideline for economic evaluation of produced water management solutions.