bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of pirfenidone on wound healing in lung transplant patients
Authors: Mortensen Amber , Cherrier Lauren , Walia Rajat 
Published: January 2020

Background: The drug pirfenidone has been shown to slow the progression and decrease mortality of idiopathic pulmonary fibrosis (IPF). Its exact mechanism is unknown, but it likely inhibits pro-fibrotic cytokine transforming growth factor beta, a known contributor to wound healing. We evaluated whether patients taking pirfenidone until lung transplantation had increased risk of impaired wound healing post-transplant. This information could determine whether pirfenidone should be discontinued prior to listing to allow for a wash-out period. Methods: We retrospectively reviewed patients who underwent lung transplantation for pulmonary fibrosis at Norton Thoracic Institute in Phoenix, Arizona, from January 2014 to December 2015. Results: We describe 18 patients who took pirfenidone up to a month before transplant. Aside from one patient who experienced sternal dehiscence due to a surgical issue, all remaining patients did well with no evidence of airway dehiscence. Each of these 17 patients had been on pirfenidone for at least 30 days; nine patients had been on pirfenidone for over 90 days. Baseline characteristics including age, sex, body mass index, renal function, liver function, glucose level, pre-transplant corticosteroid use, and post-transplant immunosuppressant therapy were similar. Conclusions: In our experience, pirfenidone may be safely continued until lung transplantation. Only one patient in our series experienced impaired wound healing related to a surgical issue, even when pirfenidone was continued until lung transplantation. We found no evidence of impaired wound healing or airway complications after lung transplantation in patients who were treated with pirfenidone before lung transplantation.
Predictors of yearly influenza vaccination in hospitalized and community-based patients
Authors: Attard Camilleri Stephanie , Casingena Juanita Camilleri , Yamagata Kentaro , Balzan Martin 
Published: January 2020

Background: Understanding positive and negative influences on adult immunization status can help healthcare providers to better identify and target patients who are likely to need immunization. Our aim was to assess and compare influenza and pneumococcal (IV/PV) immunisation rates to identify vaccination predictors in Malta.
Methods: One group consisted of all medical patients discharged from Mater Dei Hospital (MDH) over a one week period in February 2013. Patients were administered a phone questionnaire. A second group of patients receiving community-based care at local health centres over a one week period in March 2013 were interviewed, identifying vaccination eligibility as per 2010 WHO recommendations.
Results: A total of 150 community (Mean age 61.5 SD 15.8, Male 60%) and 149 hospitalised (Mean age 66.8, SD 13. 6%, Male 48.3%) patients in whom influenza vaccine was indicated were recruited. In the current year, 44 and 48.3% received the seasonal influenza vaccine, while 32.0, and 49% vaccinated yearly respectively. Pneumococcal vaccination advice was less than 5% in both groups. On stepwise binary regression, vaccination predictors for the current year were regular yearly influenza vaccination (OR 93.62, CI: 31.8–275.5, p < 0.001) and vaccination reminders (OR 27.5, CI: 9.63–78.31, p < 0.001). Nursing home residence (OR 5.78, CI: 1.22–27.4,p = 0.011), congestive cardiac failure (OR 2.11, CI: 1.1–4.08, p = 0.02) and diabetes mellitus (OR 1.68, CI: 1.04–2.72, p = 0.034) were all predictors for vaccination on exclusion of the strongest two predictors. For successive yearly vaccination, influenza vaccine recommendation by healthcare professionals (OR 12.35, CI: 4.5–33.91, p < 0.001) and vaccination reminders (OR 5.99, CI: 3.13–11.45, p < 0.01) were main predictors. Congestive cardiac failure (OR 2.37, CI: 1.20–4.7, p = 0.13) and nursing home residence (OR 7.07, CI: 1.45–34.5, p = 0,005) were also positive predictors. Male gender was a negative predictor (OR 0.51, CI: 0.31–0.83, p = 0.006). Some of those who did not vaccinate were unaware of such need (40.5% of community and 15.6% of hospitalised patients).
Conclusions: Just under half of the patient population received the IV during 2012–2013 period. Hospitalized patients are more likely to vaccinate regularly while a large proportion of community patients are unaware of the indication to vaccinate.
Alpha-1 antitrypsin deficiency as a common treatable mechanism in chronic respiratory disorders and for conditions different from pulmonary emphysema? A commentary on the new European Respiratory Society statement
Authors: Aliberti Stefano , Gramegna Andrea , Confalonieri Marco , Corsico Angelo , Richeldi Luca , Vancheri Carlo , Blasi Francesco 
Published: January 2020

Background: The European Respiratory Society recently published an important statement reviewing available evidence on diagnosis and treatment of lung disease associated to alpha-1 antitrypsin deficiency (AATD). Several issues on this topic still remain unresolved and subject of interpretation according to different standard procedures and healthcare systems worldwide. The purpose of this commentary is to offer a critical contribution to most of these controversial issues in light of an Italian perspective for the management of this disease. Main body: The clinical spectrum of AATD lung disease might include different manifestations and the traditional paradigm of a younger emphysematous patient has been revealing insufficient. Targeting with appropriate testing only COPD patients might be considered a limited approach leading to underestimation of the real prevalence of the disease. Several reports have suggested the association between AATD and other chronic respiratory conditions, as asthma and bronchiectasis. A deeper evaluation of clinical, radiological, microbiological and functional variables is, therefore, needed in order to investigate different phenotypes in AATD patients. In addition, a new line of translational research in AATD might focus on the development of personalized therapeutic regimens taking into account the patient clinical profile and needs. Conclusions: Over the past years, AATD has been interpreted as a common mechanism of inflammatory disequilibrium and tissue damage across different conditions. Future research is gradually pointing toward this new paradigm by expanding the evidence of the role of AAT as a potent immunomodulatory and anti-inflammatory drug in conditions different from pulmonary emphysema.
Manipulador móvil, bibrazo y diestro con nuevas ruedas omnidireccional
Authors: Suárez R. , Palomo-Avellaneda L. , Martínez J. , Clos D. , García N. 
Published: January 2020

<p>Este artículo describe un manipulador móvil, bimanual y con capacidad de manipulación diestra denominado MADAR (de <em>Mobile Anthropomorphic Dual-Arm Robot</em>). Básicamente puede dividirse en dos partes, una base móvil y una estructura superior portando dos brazos en configuración antropomorfa con manos mecánicas diestras equipadas con sensores táctiles. La base, completamente de desarrollo propio, es de forma circular y tiene tres ruedas con un diseño novedoso que permiten una movilidad omnidireccional. La estructura superior integra elementos comerciales, como los brazos, las manos y distintos sensores, que han sido adaptados para su funcionamiento conjunto. El artículo incluye tanto la descripción de los principales elementos del hardware como del software desarrollado para su control y uso.</p>
Downregulation of long non-coding RNA B-Raf proto-oncogene-activated non-coding RNA reverses cisplatin resistance in laryngeal squamous cell carcinoma
Authors: Han Weiwei , Niu Lin , Wang Lin , Liu Jixiang , Li Huanying 
Published: January 2020

IntroductionThis study was performed to explore the function of B-Raf proto-oncogene-activated non-coding RNA (BANCR) in laryngeal squamous cell carcinoma (LSCC) and cisplatin resistance.Material and methodsThe relative expression level of long non-coding RNA (lncRNA) BANCR was examined by qRT-PCR in tumor tissues and adjacent tissues, normal laryngeal cells (Het-1A) and laryngeal squamous carcinoma cells (TU686, TU177). Cisplatin-resistant laryngeal squamous carcinoma cell lines (TU686-DDP-R, TU177-DDP-R) were established. Next, we inhibited BANCR expression by transfecting siRNA-BANCR and enhanced BANCR expression by transfecting pcDNA3.1-BANCR into TU686, TU177, TU686-DDP-R and TU177-DDP-R cells. The CCK-8 assay and clone formation assay were performed to detect colony proliferation ability and formation ability of cells. Further, to investigate through which BANCR cell viability/formation is regulated, we detected the expression of MRP1, Bcl-2, p-PKB, and Bax by western blot.ResultsBANCR was highly expressed in laryngeal squamous carcinoma tissues and cells. Chemoresistance was generated in TU686-DDP-R and
TU177-DDP-R compared with TU686 and TU177 cells after cisplatin treatment. In addition, upregulated lncRNA BANCR reduced or postponed cell sensitivity to cisplatin by enhancing cell proliferation in TU686 and TU177 cells. Meanwhile, the expression of MRP1, Bcl-2, and p-PKB was increased, while Bax was reduced. After cisplatin treatment, down-regulation of BANCR could consequently attenuate TU686-DDP-R and TU177-DDP-R cell proliferation, and the expression of MRP1, Bcl-2, and p-PKB was decreased and Bax was increased.ConclusionsDown-regulation of BANCR reverses cisplatin resistance of cisplatin-resistant LSCC cell lines.
Validity and reliability of the Polish version of the Short Hopelessness Scale
Authors: Koryczan Paulina , Piotrowski Piotr , Roj Wojciech , Czerwiński Stanisław , Atroszko Paweł 
Published: January 2020

BackgroundThe aim of this study was to examine the psychometric properties of the Polish version of the Short Hopeless-ness Scale in an undergraduate student sample. The scale was originally developed as a brief measure of hopelessness for large scale epidemiological surveys and is based on two commonly used measures of hope-lessness.Participants and procedureA total of 4098 students from different Polish universities took part in the study. Confirmatory factor analysis (CFA) was used to test the model fit. Pearson correlation coefficients were used to investigate the relationship between hopelessness scale and criterion variables.ResultsDue to the lack of fit of the initial congeneric, unidimensional model, the lowest loading item was removed, and a tau-equivalent model with three items was tested. The tau-equivalent model showed a good fit to the data. The scale had adequate reliability. Hopelessness was positively related to anxiety, depression, and stress and negatively related to the quality of life, health, and self-esteem.ConclusionsThe study provides evidence of good psychometric properties in terms of factorial structure, reliability and crite-rion validity of the shortened 3-item Polish version of a hopelessness scale. Future studies should investigate its predictive value, especially in terms of suicidal ideation and behaviour, as well as other health outcomes.
Hand-arm vibration syndrome
Authors: Nieradko-Iwanicka Barbara 
Published: January 2020

Use of vibrating tools often leads to development of hand-arm vibration syndrome. It manifests with vascular symptoms, neurologic (carpal tunnel syndrome) and musculoskeletal symptoms (impaired grip strength, osteoarthritis, bone necrosis). Kienböck’s disease is osteonecrosis of the lunate. A 61-year-old construction worker was referred to a rheumatologist because of suspected arthritis. On examination tenderness and swelling of the dorsal aspect of the right wrist were recorded without features of inflammation. The patient reported paresthesia in the right hand when working with a pneumatic drill. He reported no morning stiffness or Raynaud’s phenomenon. He had undergone surgery because of right carpal tunnel syndrome two years earlier. Rheumatoid factor was negative, CRP 0.2 mg/l, uric acid 4.7 mg/dl. In magnetic resonance avascular necrosis of the lunate was diagnosed and scaphoid fracture. Kienböck’s disease was diagnosed. Non-steroidal anti-inflammatory drugs were used. The patient did not give consent for surgery.
The level of TGF-b in sera of patients with primary Sjögren’s syndrome
Authors: Maślińska Maria , Paradowska-Gorycka Agnieszka , Mańczak Małgorzata , Kostyra-Grabczak Kinga , Kwiatkowska Brygida 
Published: January 2020

ObjectivesTumor growth factor b (TGF-b) is a pleiotropic cytokine which controls autoimmune reactions, cell proliferation, and the organ accumulation of lymphocytes. This cytokine has a protective and anti-inflammatory effect in autoimmune processes, but also has a pro-fibrinous activity. Therefore, its importance in the development of systemic sclerosis has been proven. The role of TGF-b in Sjögren’s syndrome is also a valid direction of research. The aim of the presented study is to evaluate the level of TGF-b in sera of primary Sjögren’s syndrome patients and to investigate possible correlations with autoantibodies, cytokines, and cells in biopsy of minor salivary glands active in the pathogenesis of this syndrome.Material and methodsThirty-three primary Sjögren’s syndrome patients were included. Routine laboratory tests and immunological assessment (ANA, anti SS-A, anti SS-B antibodies, rheumatoid factor), ophthalmological assessment with ocular staining scoring, chest X-ray, and high-resolution computed tomography (if necessary) were performed. Serum concentrations of cytokines such as TGF-b, BAFF, APRIL, FLT-3L, LT-a, IL-21, and TNF-a were evaluated using standard ELISA assays. The histopathological evaluation (focus score) and the determination of CD3+, CD4+, CD19+, CD21+, CD35+ cells was performed.ResultsThere was no significant correlation between TGF-b and other tested cytokines or autoantibodies, other than TNF-a. A negative correlation (r = –0.472) between TGF-b and TNF-a was found. There were no correlations between TGF-b and: results of ocular examinations, elements of histopathological variables, or lungs changes.ConclusionsThe authors state that: 1) the results may indicate that TGF-b influences the serum TNF-a activity in pSS patients, 2) our findings suggest that TGF-b may be the strongest inhibitor of TNF-a among cytokines involved in pSS pathogenesis, and 3) the results may explain the ineffectiveness of anti-TNF drugs in the treatment of pSS.
Surface temperature response to the major volcanic eruptions in multiple reanalysis data sets
Authors: Fujiwara Masatomo , Martineau Patrick , Wright Jonathon S. 
Published: January 2020

Abstract. The global response of air temperature at 2 m above
the surface to the eruptions of Mount Agung in March 1963, El Chichón in
April 1982, and Mount Pinatubo in June 1991 is investigated using 11 global
atmospheric reanalysis data sets (JRA-55, JRA-25, MERRA-2, MERRA,
ERA-Interim, ERA-40, CFSR, NCEP-NCAR R-1, 20CR version 2c, ERA-20C, and
CERA-20C). Multiple linear regression (MLR) is applied to the monthly mean
time series of temperature for two periods – 1980–2010 (for 10 reanalyses) and 1958–2001 (for 6 reanalyses) – by considering explanatory factors of
seasonal harmonics, linear trends, quasi-biennial oscillation (QBO), solar
cycle, tropical sea surface temperature (SST) variations in the Pacific,
Indian, and Atlantic Oceans, and Arctic SST variations. Empirical orthogonal
function (EOF) analysis is applied to these climatic indices to obtain a set
of orthogonal indices to be used for the MLR. The residuals of the MLR are
used to define the volcanic signals for the three eruptions separately.
First, area-averaged time series of the residuals are investigated and
compared with the results from previous studies. Then, the geographical
distribution of the response during the peak cooling period after each
eruption is investigated. In general, different reanalyses show similar
geographical patterns of the response, but with the largest differences in
the polar regions. The Pinatubo response shows the largest average cooling in
the 60∘ N–60∘ S region among the three eruptions, with
a peak cooling of 0.10–0.15 K. The El Chichón response shows slightly
larger cooling in the NH than in the Southern Hemisphere (SH), while the
Agung response shows larger cooling in the SH. These hemispheric differences
are consistent with the distribution of stratospheric aerosol optical depth
after these eruptions; however, the peak cooling after these two eruptions
is comparable in magnitude to unexplained cooling events in other periods
without volcanic influence. Other methods in which the MLR model is used
with different sets of indices are also tested, and it is found that careful
treatment of tropical SST variability is necessary to evaluate the surface
response to volcanic eruptions in observations and reanalyses.
Las disparidades entre las cargas de dependencia demográficas provinciales. Argentina (1914-2040)
Authors: Manzano Fernando Ariel 
Published: January 2020

Se parte de la explicación de las tendencias poblacionales caracterizada en la teoría de la transición demográfica que establece un patrón de cambios en natalidad y mortalidad que conlleva inevitablemente en todas las sociedades a una ventana temporal con mínima carga de dependencia demográfica. A partir del análisis de los datos censales a nivel provincial en Argentina durante el periodo 1914-2040, se visibilizan situaciones en las cuales la carga de dependencia demográfica se caracteriza por marcadas divergencias interprovinciales. Existen provincias que inician el periodo bajo estudio con baja carga de dependencia demográfica, y se mantienen en estas posiciones a lo largo del tiempo, mientras que en otras se desvanecen las ventajas relativas iniciales, en cambio las restantes provincias sobrellevan continuamente los efectos de este desequilibrio demográfico. La hipótesis es que la ausencia del componente migratorio es la limitación principal para explicar estas supuestas irregularidades por parte la teoría demográfica. Se presenta la relación entre los valores de la relación de dependencia demográfica provinciales y los flujos migratorios según años censales.
Palabras claves: carga demográfica; migraciones; estructura de edades; teoría de la transición demográfica.
Queijos diferentes, origem geográfica comum: história e tradição da produção dos queijos do Marajó
Authors: Nascimento Elcio Costa , Cruz Benedito Ely Valente da , Calvi Miqueias Freitas 
Published: January 2020

Este trabalho apresenta uma reflexão sobre a história da produção dos queijos (manteiga e creme) do Marajó/PA, Brasil. A pesquisa, de caráter qualitativo, utilizou como ferramentas e metodologias: entrevista semiestruturada e história oral temática. Buscou-se realizar resgate histórico da produção dos queijos; analisar as formas de transmissão do conhecimento e do modo de produção; e iniciar debate sobre as dificuldades enfrentadas para a preservação dessas práticas frente às exigências da regularização sanitária dos órgãos fiscalizadores. Como resultado, observou-se a importância socioeconômica, histórica, social e cultural da produção local de queijo para as famílias envolvidas; a adaptação da produção como forma de resistência e manutenção da artesanalidade da produção; o envelhecimento dos profissionais do queijo marajoara e a diminuição do número de pessoas interessadas em desenvolver a atividade. Esta pesquisa aponta para o grau de fragilidade desse modo de produção e a necessidade de elaboração de políticas públicas que incentivem, preservem e fomentem o conhecimento tradicional e a produção artesanal dos queijos do Marajó.
Palavras-chave: Sucessão familiar; Territorialidade; Produção Familiar; Queijo artesanal.
O mapa no ensino de geografia: uma análise do trabalho docente em Madrid (Espanha) e em Goiânia (Brasil)
Authors: Richter Denis , De la Vega Alfonso García 
Published: January 2020

Este texto apresenta resultados de um estágio de pós-doutorado que teve como objetivo analisar como os professores de Geografia da Educação Infantil até o Ensino Superior de Madrid (Espanha) e de Goiânia (Brasil) trabalham com o mapa, enquanto linguagem cartográfica, em suas aulas na perspectiva de contribuir para a educação geográfica. Para isso foram realizadas entrevistas a um grupo de professores em exercício que atuam em distintos níveis escolares. Como resultado, observou-se que o mapa nas aulas de Geografia desses docentes tem sido valorizado, porém mais na perspectiva do pensamento espacial para os professores espanhóis, enquanto que os docentes brasileiros relacionam o mapa nas leituras e práticas do cotidiano. Contudo, como a formação inicial desses professores esteve vinculada fortemente à Cartografia numa perspectiva euclidiana, o trabalho com o mapa se revelou mais associado ao ensino dos conteúdos cartográficos. Espera-se com este estudo identificar proximidades e diferenças entre as práticas desses professores e que as análises provenientes possam orientar melhor o trabalho com a linguagem cartográfica nas aulas de Geografia.
Palavras-chave: Mapa; Linguagem cartográfica; Ensino de Geografia; Formação de Professores.
A “Seara” do Patrimônio Histórico no centro oeste: Análises e diálogos sobre as interrelações entre História e Arquitetura.
Authors: ZARBATO JAQUELINE Ap. Martins 
Published: January 2020

Este artigo tem como objetivo analisar as concepções sobre o Patrimônio Histórico em Mato Grosso, a partir neste processo de construção de um ‘olhar plural’, com as análises e concepções da História e da Arquitetura. Pretende-se compreender e investigar a amplitude das questões que envolvem o bem patrimonial, bem como as ressonâncias e representações ao logo do tempo Plano Nacional de Cultura ( PNC). Neste sentido, apresentamos o percurso das concepções sobre Patrimônio no Centro oeste, numa ‘seara’ de conhecimento e silenciamento.
ILUSTRES ANÔNIMOS: IMPRENSA, INTELECTUAIS E A CIRCULAÇÃO DE IDEIAS EM MATO GROSSO (1880-1920)
Authors: Pinto Adriana Aparecida 
Published: January 2020

Por meio da investigação histórica, o presente artigo indica possibilidades de análise da imprensa periódica de circulação geral, no que diz respeito à compreensão do papel dos intelectuais em um cenário comum – a configuração cultural do território mato-grossense entre os anos de 1880 a 1920. Parte-se da premissa que a imprensa deve ser colocada ao lado dos progressos materiais indicativos da modernidade, que gradativamente chegaram ao território a partir da segunda metade do século XIX. Os jornais mato-grossenses difundiram os ideais das instâncias políticas e do poder, representados pelas famílias tradicionais, que se alternavam no poder e se ramificavam pelas municipalidades. No entanto, os jornalistas, categoria fluída em termos profissionais, desfrutavam de legitimidade social, pois se vinculavam à produção, circulação e divulgação de valores (MICELI, 2001), sendo também formadores de opinião e, na concepção que orienta este texto, intelectuais-mediadores/medidores culturais. Interessa discutir como profissionais de áreas distintas constituíram-se como editores, colaboradores, articulistas, integrando a categoria de intelectuais, partindo de uma conceituação proposta por Jean-François Sirinelli (1998, 2003).