bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of iron homeostasis-related gene polymorphisms with pregnancy and neonatal outcomes in patients with gestational diabetes mellitus
Authors: Chen Xiaoli , Huang Huibin , Li Juan , Zhang Yansheng , Li Chenmeng , Xie Hongbin , Wang Lingye , Wu Qichang , Ye Huiming 
Published: December 2024

Objective
The purpose of this study was to assess associations between iron homeostasis-related gene polymorphisms and gestational diabetes mellitus (GDM), adverse pregnancy outcomes, and neonatal outcomes.

Methods
In total, 138 patients with GDM and 74 normal pregnancy controls were recruited. Time-of-flight mass spectrometry was used to genotype single-nucleotide polymorphisms (H63D rs1799945, TMPRSS6 rs855791, GDF15 rs1059369, rs4808793, BMP2 rs173107, C282Y rs3811647, rs1800562, rs269853, TF rs8177240, TFR2 rs7385804, FADS2 rs174577, and CUBN rs10904850) in 12 candidate genes related to iron homeostasis. Adverse pregnancy outcomes and neonatal health data were collected. Differences in genotype distributions and allele frequencies between patients and controls as well as their correlations with clinical factors were assessed. Additionally, associations between genotype, haemoglobin levels, and ferritin levels were evaluated.

Results
Pregnant women carrying the GDF15 rs4808793 allele (C) or TMPRSS6 rs855791 homozygous mutation (GG) had a significantly higher risk of GDM than that in the control group (p < 0.05). In patients with GDM, the BMP2 rs173107 heterozygous mutation (AC) was associated with significantly higher haemoglobin levels in late pregnancy compared with those for wild-type (AA) BMP2 (p < 0.05). Furthermore, in patients with GDM, the FADS2 rs174577 heterozygous mutation (AC) was associated with a significantly reduced risk of preterm birth (p < 0.05), the H63D rs1799945 heterozygous mutation (CG) was associated with a significantly increased risk of adverse neonatal outcomes (p < 0.05), TFR2 rs7385804 was associated a significantly reduced probability of caesarean section (p < 0.05), and the G mutation in TMPRSS6 rs855791 was related to a significantly increased probability of caesarean section (p < 0.05).

Conclusions
These results suggest that polymorphisms in genes related to iron metabolism could potentially impact pregnancy and neonatal outcomes in patients with GDM. Large-scale studies are needed to further clarify the relationship between these polymorphisms and susceptibility to GDM.
SHINE study: Developing an intervention for safe hospital insulin use for older or frail adults with diabetes undergoing surgical hospital admission: Study protocol
Authors: Lange Ferreira Christina , Donetto Sara , Habte-Asres Hellena , Govindan Jyothish , Forbes Angus , Winkley Kirsty 
Published: December 2024

Aims
To present a study protocol for the development of an intervention to enhance safe insulin use for older or frail adults undergoing a surgical admission to hospital.

Design
Following the United Kingdom’s Medical Research Council and National Institute for Health and Care Research Frameworks for development and evaluation of complex interventions; this qualitative study will use a co-design approach using design thinking, to develop a theoretical model for the intervention.

Methods
Non-participatory observations, interviews and co-design workshops will be conducted with older or frail individuals with diabetes, their caregivers and healthcare staff responsible for their care during surgical admissions at a single National Health Service hospital in England. We will utilise their experiences and perspectives to establish priorities and generate ideas for the development of a conceptual model aimed at supporting the insulin safety review process in hospitals. Data will be analysed using framework analysis. People with diabetes were involved in the design of this study. The protocol was approved by the East-Midlands-Derby Research Ethics Committee (24/EM/0022). Study registered on Open Science Framework: https://osf.io/4wvu5.

Results
Results of this study will be shared with study participants and disseminated through presentations at conferences/meetings and peer-reviewed publications.

Conclusion
This article outlines the methodology for the planned study which will employ a novel methodology to tackle the problem of hospital insulin safety. Its findings will contribute to a better understanding of the multiple interacting components implicated in hospital insulin use (patient, staff, context) and support further work around system-based strategies to enhance insulin safety resilience in hospital.
Analytically exact solution of the Schrödinger equation for neutral helium in the ground state
Authors: Kowol Frank 
Published: December 2024

This report presents the analytical solution of the Schrödinger equation and its corresponding wave function for the neutral helium, or helium-like atoms and the review of its energy levels based on literature values of the three congruent S states 1𝑆0,2𝑆0 and 3𝑆0. The entangled state function of the electrons for S,L=0 as well as their boundary conditions are examined in detail.
The basic idea is – though we treat the electron as a point like particle - not to understand its field as caused by a point charge with the rigid Coulomb field as in common approaches, but to solve the Schrödinger equation with an electric potential taking eisenberg’s uncertainty principle into account as a fundamental requirement.
Hence, a method for describing a generic electron potential is derived, and the result is integrated into the Schrödinger equation. As a direct consequence the electromagnetic coupling of the electrons was investigated by introducing an effective interaction distance 𝑑e to implement quantum electrodynamical effects.
In the next step the Schrödinger equation is solved using Laplace transformations. After determining 𝑑e iteratively from the literature ground state energy, the energies for three states 1𝑆0, 2𝑆0 and 3𝑆0 were calculated in reverse and compared again with literature values. It could be shown that with a given value 𝑑e the backward calculation gives plausible results of all three energy states within a relative error between 7.5 ∗ 10e-16 and 7.6 ∗ 10e-6, thus providing us with a convincing method to describe the helium atom analytically.
In the context of these investigations, a calculation for the spatial dimension of the interaction distance 𝑑e can be given as well as the existence of a minimal distance of a stable quasi-bonding state between two electrons in the nucleonic field. As a result, the inertness of helium regarding chemical reactions, i.e., the principle of the "closed" electron shell can be made plausible. The wave function found for the helium atom is compared with the known solutions for the hydrogen atom and Hylleraas function as well, and essential differences between those are worked out.
Muscle contractile properties and perceived fatigue in the general and diseased population
Authors: Mast Isa H. , Allard Neeltje A. E. , ten Haaf Dominique , Stoffels Anouk A. F. , Janssen Lando , van Hees Hieronymus W. H. , Timmers Silvie , Hijmans‐Kersten Bregina T. P. , Hopman Maria T. E. , Buffart Laurien M. 
Published: December 2024

AbstractKnowledge of muscle contractile properties, physical fitness, and their associations with perceived fatigue may provide insights into mechanisms inducing fatigue and treatment targets. We aimed to identify differences in contractile properties and physical fitness between populations, and examine associations with perceived fatigue. We pooled data on perceived fatigue, physical fitness, and contractile properties from six studies, including a control group (n = 90), cancer survivors (n = 27), patients with chronic obstructive pulmonary disease (COPD; n = 16), chronic myeloid leukemia (CML; n = 20), and statin users (n = 64). We evaluated differences between populations, and associations of contractile properties and physical fitness with perceived fatigue. Compared with the control group, we found differences in contractile properties of patients with COPD (larger muscle force decline: β = −10.5%, 95% CI = −16.7; −4.2, increase in early relaxation time (Rt): β = 84.4%, 95% CI = 51.7; 117.0, increase in half Rt: β = 83.1%, 95% CI = 45.5; 120.7, muscle force rise (MFR): β = 0.2%/ms, 95% CI = 0.1; 0.3, and decrease in MFR: β = −24.3%, 95% CI = −35.7; −13.0) and statin users (early Rt: β = −5.4 ms, 95% CI = −10.0; −0.8, increase in early Rt: β = 19.8%, 95% CI = 2.5; 37.1). Associations between contractile properties and perceived fatigue varied across populations. Longer relaxation times were associated with higher perceived fatigue in hemato‐oncological populations. To conclude, contractile properties were impaired in patients with COPD and statin users. Associations between contractile properties and perceived fatigue varied across populations. In hemato‐oncological populations, impaired muscle relaxation was associated with higher perceived fatigue.
CYP2C19 genotype-phenotype correlation: current insights and unanswered questions
Authors: Torso Nadine de Godoy , Rodrigues-Soares Fernanda , Altamirano Catalina , Ramírez-Roa Ronald , Sosa-Macías Martha , Galavíz-Hernández Carlos , Terán Enrique , Peñas-LLedó Eva , Dorado Pedro , LLerena Adrián 
Published: December 2024

Abstract
The CYP2C19 enzyme is implicated in the metabolism of several clinically used drugs. Its phenotype is usually predicted by genotyping and indicates the expected enzymatic activity for each patient. However, with a few exceptions, CYP2C19 genotyping has not resulted in a reliable prediction of the metabolizer status, since most of the evidence currently available for this prediction comes from research into populations of predominantly European ancestry. Therefore, this review discusses the main factors that may alter the expected phenotype, as well as the urgent need to include ethnically diverse populations in further studies, so that, in the long term, it is possible to establish guidelines appropriate to these groups.
Designing Hydrogen Permeation Barriers in Titanium Aluminium Nitride through First Principles Density Functional Theory Calculations
Authors: Örnek C. , Fechte-Heinen R. 
Published: December 2024

Abstract
We investigated hydrogen permeation in titanium aluminium nitride (TiAlN) using ab initio density functional theory (DFT) for cubic and hexagonal crystal structures. Despite the significance of hydrogen barriers, the potential of TiAlN has not been fully explored. We analyzed site specificity, temperature-dependent insertion, and atomic hydrogen migration path energies. Our research highlights the decisive role of crystallographic structure over chemical composition in designing materials resistant to hydrogen absorption. However, once absorbed, hydrogen diffusion is governed by the local chemical environment. Specifically, hydrogen migration through an Al-N plane requires more energy than through Ti-N, which affects the overall diffusion process. We found hydrogen absorption is highly endothermic, with insertion energies from 50 to 320 kJ/mol of hydrogen atoms, indicating low uptake probability at ambient conditions. Higher temperatures further increase the energy required, making absorption less favourable. We also identified substantial energy barriers in the hexagonal structure, with peaks up to 276 kJ/mol, indicating a very low probability of migration for hydrogen. These findings underscore TiAlN’s exceptional resistance to hydrogen permeation, making it suitable for hydrogen storage applications.
Revisiting linearly extended discrete functions
Authors: Gravel Claude , Panario Daniel 
Published: December 2024

Abstract
The authors introduced a new family of cryptographic schemes in a previous research article, which includes many practical encryption schemes, such as the Feistel family. Given a finite field of order

q

q

, any

n
>
m
≥
0

n\gt m\ge 0

, the authors described a new way to extend discrete functions with domain size

q

m

{q}^{m}

and range size

q

n
−
m

{q}^{n-m}

to a permutation over

q

n

{q}^{n}

elements using theory from linear error correcting codes. The authors previously showed that the knowledge about the differentials and correlations of the resulting permutation reduces solely to those of the extended discrete function. We show how the perfect secrecy of extended nonlinear functions transfers to the family of bijective linear extensions. We investigate how the concrete security of the family of nonlinear functions relates to the family of permutations obtained by such a type of linear extension. We also explore how the interplay between the entropy and the total variation distance (near-perfect secrecy with unbounded adversary) affects the mixing rate (number of iterations of the feedback linear extensions) with respect to the uniform distribution of the permutations over

q

n

{q}^{n}

elements. We give a new proof that a distribution close to the uniform distribution has a large entropy.
Trade in the Face of Terror: Examining Turkey’s Export Dynamics
Authors: Ünlü Evrim Zeynep 
Published: December 2024

Abstract
In the preceding 11 years, Turkey has witnessed 925 terrorist incidents, resulting in the unexpected passing of 1,439 people. Concurrently, the neighbouring nations, Syria, and Iraq, have also experienced a multitude of terrorist activities. This study’s main objective is to explore how these events have affected Turkey’s exports and intra-industry trade. The investigation is centred on Turkey’s trade relationships with 71 countries, representing its primary trading partners, employing a one-way trade model. Utilizing the Poisson pseudo maximum likelihood (PPML) estimator, the study spans 2012 to 2022. The findings underscore the adverse impact of domestic terrorist incidents, casualties in other countries, and the global terrorism index on Turkey’s exports. Surprisingly, the investigation finds a positive connection between Turkey’s exports and terrorist incidents in both neighbouring and non-bordering countries. Furthermore, the empirical analysis sheds light on Turkey’s engagement in intra-industry trade concerning manufacturing industry and GDP similarities. However, the scenario changes for information and communication technology (ICT) exports, revealing an inter-type of industry trade.
Quadratic-exponential growth backward stochastic Volterra integral equations with jumps and associated dynamic risk measure
Authors: Kim Kon-Gun , Pak Ji-Gwon , Kim Mun-Chol 
Published: December 2024

Abstract
Risk management is one of the fundamental concepts in the mathematical finance.
We study quadratic-exponential growth Backward Stochastic Volterra Integral Equations with Jumps (QBSVIEJs, for short).
We prove the existence and uniqueness of solutions to QBSVIEJ in two steps.
First, we use the fact that a QBSVIEJ with the generator independent of 𝑦 can be represented by a (infinite) family of QBSDEJs to get the first simple well-posedness result.
And secondly, we use fixed point argument and induction to deal with the general case.
We prove a comparison theorem and, as an application, define a convex dynamic risk measure by means of the QBSVIEJs.
The Role of “The Talk” and Its Themes in Black Youths’ Anticipatory Stress of Police Brutality
Authors: Webb Lindsey , Jindal Monique , Karbeah J’Mag , Testa Alexander , Fix Rebecca L. , Jackson Dylan B. 
Published: December 2024

BACKGROUND AND OBJECTIVES
Research on conversations between caregivers and their children about how to prepare or conduct themselves when stopped by police (ie, “the talk”) has grown in recent years. However, little is known about how having “the talk” may influence youths’ stress about future experiences of police brutality (ie, anticipatory stress of police brutality). The objective of the present study is to examine how youths’ anticipatory stress regarding police brutality varies by whether they have had “the talk” with their caregivers.

METHODS
Data come from the Survey of Police-Adolescent Contact Experiences (SPACE), a cross-sectional survey of a community-based sample of Black youth aged 12 to 21 years in Baltimore, Maryland (n = 339), collected from August 2022 to July 2023. Multivariable ordinary least squares regressions were conducted to (1) examine associations between “the talk” and anticipatory stress of police brutality among a sample of Black youth in Baltimore and (2) examine the associations between messages in “the talk” and anticipatory stress of police brutality among youth who received “the talk.”

RESULTS
Findings indicate that having “the talk” was associated with lower anticipatory stress of police brutality. Moreover, among youth who received “the talk,” certain messages from parents during “the talk” were associated with significant increases in anticipatory stress of police brutality compared with other messages.

CONCLUSIONS
Findings underscore the need for a nuanced understanding of “the talk’s” broader implications on youth well-being and may be used to expand opportunities for youth to encounter affirmative racial socialization messages.
Por que observar critérios psicolinguísticos?
Authors: Dos Santos Rodrigues Erica , Cristine Hübner Lilian , Rodrigues Bastos Ana Paula 
Published: December 2024

A aplicação de critérios psicolinguísticos na construção de tarefas linguísticas para avaliação de desempenho linguístico-cognitivo em pesquisas e práticas educacionais e clínicas pode garantir a confiabilidade dos dados obtidos. O presente artigo, fundamentado em referenciais teóricos e em procedimentos metodológicos da Psicolinguística, busca evidenciar a importância da adoção de critérios psicolinguísticos no desenvolvimento de tarefas, indicando os fatores que devem ser observados, dependendo do objetivo do estudo ou da prática, na produção de estímulos nos níveis da palavra, da sentença e do texto. A adoção dos critérios é justificada a partir de exemplificações de aplicações nas áreas da Educação e da Saúde, com o intuito de demonstrar o potencial desse tipo de abordagem na identificação de perfis de desempenho individuais ou de grupos, em populações típicas ou atípicas. O artigo inclui também considerações sobre o desenho das tarefas e a utilização de recursos computacionais de apoio. Espera-se contribuir para a instrumentalização de pesquisadores, educadores e clínicos, com potencial de aplicação em outras áreas interdisciplinares.
Developmental and Cell Fate Analyses Support a Postnatal Origin for the Cortical Collecting System in the Mouse Kidney
Authors: Parvez Riana K. , Csipán Réka L. , Liu Jing , Gevorgyan Ara , Rutledge Elisabeth A. , Guo Jinjin , Kim Doh Kyung , McMahon Andrew P. 
Published: December 2024

Key Points

An adult-like corticomedullary organization underlying kidney function is established 10 days after birth in the mouse kidney.Genetic lineage tracing demonstrates the cortical collecting duct network is generated from progenitors after birth.Mature cell types of the nephron progenitor–derived connecting tubule and ureteric progenitor–derived collecting epithelium are established by P15.

Background
Structure and function in the mammalian kidney are organized along a radial axis highlighted by the corticomedullary organization and regional patterning of the collecting system. The arborized collecting epithelium arises through controlled growth, branching, and commitment of Wnt11+ ureteric progenitor cells within cortically localized branch tips until postnatal day 3.

Methods
We applied in situ hybridization and immunofluorescence to key markers of collecting duct cell types to examine their distribution in the embryonic and postnatal mouse kidneys. To address the contribution of ureteric progenitor cells at a given time to cell diversity and spatial organization in the adult mouse kidney, we performed genetic lineage tracing of Wnt11

+
cells in the embryonic and early postnatal mouse kidney.

Results
Cell fate analyses showed much of the cortical collecting duct network was established postnatally. Furthermore, epithelial reorganization, regional differentiation, and functional maturation of key cell types to an adult-like collecting epithelium was not complete until around 2 weeks after birth in both ureteric progenitor cell–derived collecting system and structurally homologous nephron progenitor cell–derived connecting tubule.

Conclusions
These studies underline the importance of the relatively understudied early postnatal period to the development of a functional mammalian kidney.
СОВРЕМЕННАЯ РОССИЙСКАЯ СЕМЬЯ: ПОТРЕБНОСТИ И ИНСТИТУЦИОНАЛЬНЫЕ РЕСУРСЫ ПОДДЕРЖКИ (НА ПРИМЕРЕ ВОЛГОГРАДСКОЙ ОБЛАСТИ)
Authors: Полтавская Мария Борисовна , Васильев Евгений Сергеевич , Гуляев Святослав Борисович 
Published: December 2024

Целью исследования является выявление потребностей современной семьи, описание и характеристика институциональных ресурсов современной семьи на основе вторичных данных социологического опроса семей Волгоградской области.
Методологическую базу исследования составили российские и зарубежные труды, рассматривающие семью как социальный институт в рамках двух парадигм: модернизационной парадигмы, представленной теорией демографического перехода, и кризисной парадигмы, представленной теорией институционального кризиса семьи. Выявлено, что исследований, оценивающих институциональные ресурсы российских семей, недостаточно. Эмпирической базой исследования послужил вторичный анализ данных анкетирования, проведенного в 2022 году в Волгоградской области, n = 826, выборка квотная по территории проживания и социально-демографическим характеристикам населения Волгоградской области.
Результаты исследования показали, что основным институциональным ресурсом поддержки семей является материальная (финансовая) поддержка. Материнский (семейный) капитал — это основное экономическое средство стимулирования рождаемости, однако его действие не оказывает решающего влияния на итоговую рождаемость. Выявлено, что причины, по которой женщины Волгоградской области решились бы на рождение еще одного ребенка, связаны не только с материнским капиталом, но и с доступностью качественного медицинского обслуживания, дошкольных образовательных учреждений. Определен недостаточный уровень информированности о наборе оказываемых социальных услуг, а также трудности в связи с бюрократизацией процесса получения услуг, что требует пересмотра политики информирования семей в регионе и корректировки регламентов предоставления социальных услуг.
Перспективы исследования. Обобщенные данные о потребностях и институциональных ресурсах семей Волгоградской области могут быть использованы при корректировке методов работы с семьями.