bluuebunny/crossref_metadata_2025_split huggingface dataset:
Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response
Authors: Montesion Meagan , Murugesan Karthikeyan , Jin Dexter X. , Sharaf Radwa , Sanchez Nora , Guria Ameet , Minker Max , Li Gerald , Fisher Virginia , Sokol Ethan S. , Pavlick Dean C. , Moore Jay A. , Braly Alan , Singal Gaurav , Fabrizio David , Comment Leah A. , Rizvi Naiyer A. , Alexander Brian M. , Frampton Garrett M. , Hegde Priti S. , Albacker Lee A. 
Published: October 2020

Abstract

Neoantigen presentation arises as a result of tumor-specific mutations and is a critical component of immune surveillance that can be abrogated by somatic LOH of the human leukocyte antigen class I (HLA-I) locus. To understand the role of HLA-I LOH in oncogenesis and treatment, we utilized a pan-cancer genomic dataset of 83,644 patient samples, a small subset of which had treatment outcomes with immune checkpoint inhibitors (ICI). HLA-I LOH was common (17%) and unexpectedly had a nonlinear relationship with tumor mutational burden (TMB). HLA-I LOH was frequent at intermediate TMB, yet prevalence decreased above 30 mutations/megabase, suggesting highly mutated tumors require alternate immune evasion mechanisms. In ICI-treated patients with nonsquamous non–small cell lung cancer, HLA-I LOH was a significant negative predictor of overall survival. Survival prediction improved when combined with TMB, suggesting TMB with HLA-I LOH may better identify patients likely to benefit from ICIs.

Significance:
This work shows the pan-cancer landscape of HLA-I LOH, revealing an unexpected “Goldilocks” relationship between HLA-I LOH and TMB, and demonstrates HLA-I LOH as a significant negative predictor of outcomes after ICI treatment. These data informed a combined predictor of outcomes after ICI and have implications for tumor vaccine development.
This article is highlighted in the In This Issue feature, p. 211
Thrasymachus on Justice, Rulers, and Laws in Republic I
Authors: Everson Stephen 
Published: October 2020

One issue of contention amongst scholars of the Republic is whether Thrasymachus initially espouses a conventionalist account of justice, according to which just actions are merely those which are lawful; required, or at least allowed, by the laws passed by the ruler of the state. A further question is then whether his initial conceptions of rulers and laws are positivist ones, such that to be a ruler or law of a state is simply determined by the state’s constitution (or indeed by the ruler’s ability to enforce obedience). At 340c Thrasymachus effectively rejects such positivism by placing a condition on being a ruler that one should be exercising the art of ruling and on being a law that it should work to the ruler’s interest. Some have maintained that this works to clarify his initial account and so shows that he was never a positivist about rulers and laws. In this paper I argue against such an understanding of Thrasymachus’ argument and explore the problems which beset the position he is, on my reading, forced into by Socrates’ objection to his opening claim that justice is what is in the interest of the stronger and the argument he first gives to support it.
Employment Protection Deregulation and Labor Shares in Advanced Economies
Authors: Ciminelli Gabriele , Duval Romain , Furceri Davide 
Published: October 2020

Abstract
This paper assesses the impact of job protection deregulation on the labor share in a sample of 26 advanced economies during the 1970–2013 period, using a newly constructed dataset of major reforms in this area. We employ a difference-in-differences identification strategy using two identifying assumptions grounded in theory—deregulation has larger effects in industries characterized by (i) a higher “natural” propensity to regularly adjust the workforce and (ii) a lower elasticity of substitution between capital and labor. We find significant negative effects of deregulation on the labor share, contributing to about a tenth of its observed decline in advanced economies.
Patents, Data Exclusivity, and the Development of New Drugs
Authors: Gaessler Fabian , Wagner Stefan 
Published: October 2020

Abstract
Pharmaceutical firms enjoy market exclusivity for new drugs from concurrent patent protection and exclusivity of the clinical trials data submitted for market approval. Patent invalidation during drug development renders data exclusivity the sole source of protection and shifts the period of market exclusivity. In instrumental variables regressions, we quantify the effect of a one-year reduction in expected market exclusivity on the likelihood of drug commercialization. The effect is largely driven by patent invalidations early in the drug development process and by the responses of large originators. We provide estimates of the responsiveness of R&D investments to market exclusivity expectations.
The Gender Promotion Gap: Evidence from Central Banking
Authors: Hospido Laura , Laeven Luc , Lamo Ana 
Published: October 2020

Abstract
We examine gender differences in career progression and promotions using personnel data from the European Central Bank (ECB) during the period 2003–2017. A gender wage gap emerges within a few years of hiring, despite broadly similar entry conditions. We also find a gender promotion gap before 2010 when the ECB issued a public commitment to diversity. Following this change, the promotion gap disappears. Using data on promotion applications, we find a gender application bias, partly driven by preferences for competition. Following promotion, women perform better in terms of salary progression.
Bridging Level-K to Nash Equilibrium
Authors: Levin Dan , Zhang Luyao 
Published: October 2020

Abstract
We introduce NLK, a model that connects the Nash equilibrium (NE) and level-k. It allows a player in a game to believe that her opponent may be either less or as sophisticated as she is, a view supported in psychology. We apply NLK to data from five published papers on static, dynamic, and auction games. NLK provides different predictions from those of the NE and level-k; moreover, a simple version of NLK explains the experimental data better in many cases, with the same or fewer parameters. We discuss extensions to games with more than two players and heterogeneous beliefs.
Choosing Your Pond: Location Choices and Relative Income
Authors: Bottan Nicolas L. , Perez-Truglia Ricardo 
Published: October 2020

Abstract
Do individuals care about their relative income? While this is a long-standing hypothesis, revealed-preference evidence remains elusive. We provide a unique test by studying residential choices: individuals often must choose between places with different income distributions, and as a result they “choose” their relative income. We conducted a field experiment with 1,080 senior medical students who participated in the National Resident Matching Program. We estimate their preferences by combining choice data, survey data on perceptions, and information-provision experiments. The evidence suggests that individuals care about their relative income and that these preferences differ across single and nonsingle individuals.
Housing Discrimination and the Toxics Exposure Gap in the United States: Evidence from the Rental Market
Authors: Christensen Peter , Sarmiento-Barbieri Ignacio , Timmins Christopher 
Published: October 2020

Abstract
Local pollution exposures have a disproportionate impact on minority households, but the root causes remain unclear. This study conducts a correspondence experiment on a major online housing platform to test whether housing discrimination constrains minority access to housing options in markets with significant sources of airborne chemical toxics. We find that renters with African American or Hispanic/Latinx names are 41% less likely than renters with white names to receive responses for properties in low-exposure locations. We find no evidence of discriminatory constraints in high-exposure locations, indicating that discrimination increases relative access to housing choices at elevated exposure risk.
Aggregate Effects from Public Works: Evidence from India
Authors: Cook C. Justin , Shah Manisha 
Published: October 2020

Abstract
This paper explores the aggregate economic effects from India's National Rural Employment Guarantee Scheme (NREGS), which provides up to 100 days of labor to rural laborers at the mandated minimum wage. We examine the within-district change to nighttime lights, a proxy for economic development, and banking deposits using the staggered program rollout for identification. We find consistent and robust evidence that NREGS increased aggregate economic output by 1% to 2% per capita measured by nighttime lights. This effect, however, is not equal across districts. We observe no positive effect of the program in poorer districts, illuminating an important source of heterogeneity.
Civilisation, Protection, Restitution: A Critical History of International Cultural Heritage Law in the 19th and 20th Century
Authors: Spitra Sebastian M. 
Published: October 2020

Abstract
This article provides a new narrative for the history of cultural heritage law and seeks to contribute to current legal debates about the restitution of cultural objects. The modern protection laws for cultural objects in domestic and international law evolved in the 19th and 20th century. The article makes three new arguments regarding the emergence of this legal regime. First, ‘civilisation’ was a main concept and colonialism an integral part of the international legal system during the evolution of the regime. The Eurocentric concept of civilisation has so far been an ignored catalyst for the international development of cultural heritage norms. Second, different states and actors used cultural heritage laws and their inherent connection to the concept of civilisation for different purposes. Third, the international legal system of cultural heritage partly still reflects its colonial roots. The current restitution discussions are an outcome of this ongoing problematic legal constellation.
Indo-European phylogenetics with R
Authors: Goldstein David 
Published: October 2020

Abstract
The last twenty or so years have witnessed a dramatic increase in the use of computational methods for inferring linguistic phylogenies. Although the results of this research have been controversial, the methods themselves are an undeniable boon for historical and Indo-European linguistics, if for no other reason than that they allow the field to pursue questions that were previously intractable. After a review of the advantages and disadvantages of computational phylogenetic methods, I introduce the following methods of phylogenetic inference in R: maximum parsimony; distance-based methods (UPGMA and neighbor joining); and maximum likelihood estimation. I discuss the strengths and weaknesses of each of these methods and in addition explicate various measures associated with phylogenetic estimation, including homoplasy indices and bootstrapping. Phylogenetic inference is carried out on the Indo-European dataset compiled by Don Ringe and Ann Taylor, which includes phonological, morphological, and lexical characters.
#Mesh: Social Media and Its Influence on Perceptions in Hernia Repair
Authors: Fadaee Negin , Huynh Desmond , Towfigh Shirin 
Published: October 2020

Social media can influence public perception in health care. By 2016, social media discussion against the use of transvaginal mesh influenced changes in Food and Drug Administration (FDA) regulations. We propose that the fate of hernia mesh will follow that of transvaginal mesh. Thus, we compare the trend of social media discussion of hernia and transvaginal mesh. Posts on Twitter and public Facebook groups were tracked for keywords “hernia,” “hernia mesh,” and “pelvic/vaginal mesh.” Posts were categorized based on sentiment. On Facebook, 16 public groups with 14 526 members expressed negative sentiments in 95% of their 750 daily posts. Meanwhile, of the 1.1 million tweets on Twitter, those about hernia mesh were more negative (36.5%) than those about pelvic/vaginal mesh (29.2%). Three of the 5 top tweeters about hernia mesh and pelvic/vaginal mesh were linked to law firms involved in mesh-based lawsuits. The negative sentiments and steering of social media discussion by lawyers may directly affect surgical care. As surgeons, we may adapt our informed consent to acknowledge our patients’ apprehensions about mesh. We may also be more involved in social media discussions ourselves. Meanwhile, we await FDA decisions in the regulation and availability of hernia mesh.
Prolonged grief in refugees, parenting behaviour and children’s mental health
Authors: Bryant Richard A , Edwards Ben , Creamer Mark , O’Donnell Meaghan , Forbes David , Felmingham Kim L , Silove Derrick , Steel Zachary , McFarlane Alexander C , Van Hooff Miranda , Nickerson Angela , Hadzi-Pavlovic Dusan 
Published: October 2020

Background: Many refugees experience bereavement, and as a result they suffer elevated rates of prolonged grief disorder. Evidence also indicates that elevated rates of psychological disturbance in refugee children can be associated with parental mental health. This study examined the extent to which prolonged grief disorder in refugees is associated with their parenting behaviour and in turn with their children’s mental health. Methods: This study recruited participants from the Building a New Life in Australia prospective cohort study of refugees admitted to Australia between October 2013 and February 2014. The current data were collected in 2015–2016 and comprised 1799 adults, as well as 411 children of the adult respondents. Adult refugees were assessed for trauma history, post-migration difficulties, harsh and warm parenting, probable prolonged grief disorder and posttraumatic stress disorder. Children were administered the Strengths and Difficulties Questionnaire. The current analyses on bereaved refugees comprise 110 caregivers and 178 children. Results: In this cohort, 37% of bereaved refugees reported probable prolonged grief disorder. Path analysis indicated that caregivers’ grief was directly associated with children’s emotional difficulties. Caregiver warmth was associated with reduced emotional problems in children of refugees with minimal grief but associated with more emotional problems in caregivers with more severe grief. More harsh parenting was associated with children’s conduct problems, and this was more evident in those with less severe grief. Conclusion: Severity of prolonged grief disorder is directly linked to refugee children’s mental health. The association between parenting style, grief severity and children’s mental health highlights that managing grief reactions in refugees can benefit both refugees and their children.
On the Effect of a Binary Treatment in the Presence of a Control Covariate
Authors: Majumdar Rajeshwari 
Published: October 2020

The nonparametric regression of a response variable on a binary treatment and a control covariate equals the nonparametric regression of the response on the control plus the conditional (given the control) linear regression of the resulting residual on the residual of the nonparametric regression of the treatment on the control. While similar decompositions are typically obtained using the technique of orthogonal projection applicable to random variables with finite second moments, this result holds if the response only has a finite first moment and allows the control to be completely arbitrary. Consequently, if the propensity score of the treatment is bounded away from zero and one, the treatment effect, after controlling for the covariate, equals the ratio of the conditional covariance of the response and the treatment to the conditional variance of the treatment. AMS 2020 subject classification: Primary 62G08, Secondary 62J05, 91F10, 62P20, 62P25
Evaluating Lumbar Shape Deformation With Fabric Strain Sensors
Authors: Vu Linh Q. , Kim Han , Schulze Lawrence J. H. , Rajulu Sudhakar L. 
Published: October 2020

Objective To better study human motion inside the space suit and suit-related contact, a multifactor statistical model was developed to predict torso body shape changes and lumbar motion during suited movement by using fabric strain sensors that are placed on the body. Background Physical interactions within pressurized space suits can pose an injury risk for astronauts during extravehicular activity (EVA). In particular, poor suit fit can result in an injury due to reduced performance capabilities and excessive body contact within the suit during movement. A wearable solution is needed to measure body motion inside the space suit. Methods An array of flexible strain sensors was attached to the body of 12 male study participants. The participants performed specific static lumbar postures while 3D body scans and sensor measurements were collected. A model was created to predict the body shape as a function of sensor signal and the accuracy was evaluated using holdout cross-validation. Results Predictions from the torso shape model had an average root mean square error (RMSE) of 2.02 cm. Subtle soft tissue deformations such as skin folding and bulges were accurately replicated in the shape prediction. Differences in posture type did not affect the prediction error. Conclusion This method provides a useful tool for suited testing and the information gained will drive the development of injury countermeasures and improve suit fit assessments. Application In addition to space suit design applications, this technique can provide a lightweight and wearable system to perform ergonomic evaluations in field assessments.
Frequency of potential causes of lower back pain and incidental findings in patients with suspected sacroiliitis: retrospective analysis of 886 patients with negative sacroiliac MRI examination for sacroiliitis
Authors: Kaya Hasan Emin , Kerimoğlu Ülkü 
Published: October 2020

Background In a majority of patients with suspected sacroiliitis (SI) who underwent sacroiliac magnetic resonance imaging (MRI), imaging studies may be normal, may depict other causes for pain, or may show clinically irrelevant incidental findings. Purpose To determine the prevalence of possible etiologies other than SI and frequency of incidental findings demonstrated on sacroiliac MRI examinations in a cohort of patients with lower back pain and suspected SI. Material and Methods Sacroiliac MRI examinations of 1421 patients with suspected SI were retrospectively reviewed. In patients without SI findings, other potential causes for lower back pain and incidental findings were documented. Results SI was present in 535 of 1421 patients (37.6%). In 886 of the patients whose MRI studies were negative for SI, other possible causes for lower back pain or incidental findings were seen in 386 (43.5%). The most common musculoskeletal (MSK) finding was lumbosacral transitional vertebra (8.6%) followed by findings suggesting piriformis syndrome (4.2%), spondylosis (3.7%), and sacral insufficiency fractures (1.8%). The most common non-MSK findings were follicular cysts (15.3%) and uterine fibroids (4.9%). Conclusion In patients with suspected SI but negative MRI examinations for SI, some other possible causes for lower back pain and several incidental findings can be seen on imaging. The presence of these findings may explain the patient’s symptoms, and awareness of these conditions may be helpful in patient management and individualizing treatment.
Effect of gonadotropins and endometrial thickness on pregnancy outcome in patients with unexplained infertility or polycystic ovarian syndrome undergoing intrauterine insemination
Authors: Li Qing , Zhu Maoling , Deng Zhuxiu , Wang Lihua , Huang Yi , Ruan Liming , Hu Shaofei , Wang Liping 
Published: October 2020

Objective The purpose of this study was to investigate the effect of gonadotropin dose and endometrial thickness (EMT) on pregnancy outcome in patients undergoing intrauterine insemination (IUI). Methods We retrospectively analyzed data from 361 patients with unexplained infertility or polycystic ovarian syndrome (PCOS) who underwent 930 IUI cycles treated with gonadotropins. Then, we measured the effects of gonadotropins and EMT on the clinical pregnancy rate. Finally, we assessed the association of various doses of gonadotropins on EMT. Results The dose of gonadotropins given and thickness of the endometrium were higher in the pregnancy group than in the nonpregnancy group (636.0 vs. 600.0 IU for gonadotropin dose; 9.15 vs. 8.70 mm for EMT). Clinical pregnancy rates were significantly improved by increasing the dose of gonadotropins (9.1%, <450 IU; 16.2%, 450–599 IU; 18.6%, 600–749 IU, and 17.3%, ≥750 IU), or by increased EMT (0%, <5.0 mm; 12.2%, 5.0–6.9 mm; 15.5%, 7.0–14.0 mm; and 33.3%, >14.0 mm). Conclusion Increasing the dose of gonadotropins to stimulate one follicle to develop may benefit endometrial proliferation and improve IUI outcomes.
90-Day Complication Rate After the Latarjet Procedure in a High-Volume Center
Authors: Scanlon John P. , Hurley Eoghan T. , Davey Martin S. , Gaafar Mohamed , Pauzenberger Leo , Moran Cathal J. , Mullett Hannan 
Published: October 2020

Background: The Latarjet procedure is indicated for patients with recurrent anterior shoulder instability, previous failed soft tissue stabilization, glenoid bone loss, or high-risk factors for recurrence, although there is still a concern with the surgical complication rates associated with the Latarjet procedure. Purpose: To evaluate the 90-day complication rate after the open Latarjet procedure in a high-volume center. Study Design: Case series; Level of evidence, 4. Methods: A retrospective review was performed of patients who underwent an open Latarjet procedure at our institution over a 5-year period between January 2015 and December 2019. The complications, readmissions, and reoperations within 90 days were evaluated. Results: A total of 441 patients with a mean age of 23.0 ± 5.7 years was included; 97.5% of the patients were male. There were 2 intraoperative complications (0.5%): 1 coracoid fracture and 1 anaphylactic reaction to vancomycin. Overall, there were 19 postoperative complications (4.3%) in 18 patients, with 4 (0.9%) readmissions for revision surgery. Hematomas were the most common complication, occurring in 12 patients (2.7%), with 9 (2.0%) requiring a return to the operating theater during their stay for an evacuation. In those who required a readmission for a reoperation, 1 was for a hematoma requiring a washout, 2 were for irrigation and debridement of a surgical site infection, and the third was for a biceps tenodesis in a patient with severe bicipital pain. No patients had recurrence or any postoperative graft complications; additionally, there were no neurovascular complications. Conclusion: We found that in a high-volume center, the open Latarjet procedure has a low 90-day complication rate with a low revision rate. Hematomas were the most common complication experienced by patients who underwent the Latarjet procedure, while there was no recurrent instability or neurological or hardware complications reported among the 441 patients included in this study.