bluuebunny/crossref_metadata_2025_split huggingface dataset:
SELECTION OF OPTIMAL CONDITIONS FOR ACCUMULATION AND EXTRACTION OF PHENOLIC COM-POUNDS FROM BIOTECHNOLOGICAL RAW MATERIALS OF IRIS L. REPRESENTATIVES
Authors: Tikhomirova Lyudmila Ivanovna , Bazarnova Natal'ya Grigor'yevna , Bondarev Aleksandr Aleksandrovich , Ponomareva Yaroslava Viktorovna , Mironova Steniya Olegovna 
Published: August 2020

For optimal accumulation of biomass and phenolic compounds (flavonoids, tannins, xanthones, hydroxycinnamic acids) from Iris sibirica and Iris spuria in tissue culture, it is desirable to use a medium containing 1.0 to 2.5 µm BAP. The high content of cytokinin caused a stressful situation, at the first stage of which there was a mass formation of adventitious and axillary shoots, then with an increase in the concentration of the hormone, the reproduction coefficient decreased, the plants stopped reproducing, stopped growing and died. In extreme conditions, phenolic compounds are spent on the performance of protective functions, in connection with which there was a drop in their overall level in the tissues of irises.
For biotechnological raw materials of Iris L. representatives, the efficiency of subcritical sequential extraction was compared with traditional methods (in Soxlet type apparatus). In subcritical conditions have been removed more flavonoids and tannins: in fraction 96% ethanol of flavonoids and tannins – in 2 times; at a fraction of 60% ethanol flavonoids – 2 times, tanning – 3 times; at a fraction of the water of flavonoids in 3 times, tanning – 1.4 times. The water in the apparatus of soxlet extracted 1.3 times more hydroxycinnamic acids than in subcritical conditions.
The ratio of condensed and hydrolyzable tannins tannins in aeroponic raw material of Iris sibirica L. varieties Sterkh traditional extraction was determined as 13 : 1, the extraction in subcritical conditions 8 : 1.
Anatomical Variation in Mesenteric Macrophage Phenotypes in Crohn's Disease
Authors: van der Meer Jonathan H.M. , Wasmann Karin A.T.G.M. , van der Bilt Jarmila D.W. , Becker Marte A.J. , Boermeester Marja A. , Bemelman Willem A. , Wildenberg Manon E. , Buskens Christianne J. 
Published: August 2020

INTRODUCTION:
Clinical trials are currently investigating whether an extended mesenteric resection for ileocecal resections could reduce postoperative recurrence in Crohn's disease. Resection of the mesorectum, which contains proinflammatory macrophages, during proct(ocol)ectomy, is associated with reduced recurrent inflammation and improved wound healing. We aimed to characterize the macrophages in the ileocecal mesentery, which were compared with those in the mesorectum, to provide a biological rationale for the ongoing trials.

METHODS:
In 13 patients with Crohn's disease and 4 control patients undergoing a proctectomy, tissue specimens were sampled at 3 locations from the mesorectum: distal (rectum), middle, and proximal (sigmoid). In 38 patients with Crohn's disease and 7 control patients undergoing ileocecal resections, tissue specimens also obtained from 3 locations: adjacent to the inflamed terminal ileum, adjacent to the noninflamed ileal resection margin, and centrally along the ileocolic artery. Immune cells from these tissue specimens were analyzed by flow cytometry for expression of CD206 to determine their inflammatory status.

RESULTS:
In the mesorectum, a gradient from proinflammatory to regulatory macrophages from distal to proximal was observed, corresponding to the adjacent inflammation of the intestine. By contrast, the ileocecal mesentery did not contain high amounts of proinflammatory macrophages adjacent to the inflamed tissue, and a gradient toward a more proinflammatory phenotype was seen in the central mesenteric area.

DISCUSSION:
Although the mesentery is a continuous structure, the mesorectum and the ileocecal mesentery show different immunological characteristics. Therefore, currently, there is no basis to perform an extended ileocecal resection in patients with Crohn's disease.
Stuck in an Existential Quagmire: The Role of Perceived True Self-Knowledge in Client Stuckness
Authors: Carter Jane E. M. , Rivera Grace N. , Heffer Robert W. , Schlegel Rebecca J. 
Published: August 2020

Introduction: Research suggests that perceived true self-knowledge is important for well-being. However, less discussion exists about how perceived true self-knowledge affects therapy outcomes. We suggest that perceived true self-knowledge may be important when attempting to address client stuckness (i.e., lack of progress in therapy; Beaudoin, 2008). We argue that when clients perceive a lack of true self-knowledge, they are unable to draw upon the true self-concept as a source of meaning. This may hinder therapeutic progress and contribute to client stuckness.Methods: We present theoretical evidence for the role of perceived true self-knowledge in experiences of stuckness. Then, we present case studies of two stuck clients and their therapeutic interventions as preliminary evidence for our model.Results: Direct strategies geared at enhancing true self-knowledge by helping the client construct coherent self-concepts worked for one client, but not for the other. Indirect strategies, grounded in social psychological research, are outlined as a method of enhancing perceptions of true self-knowledge for clients who do not benefit from direct strategies.Discussion: Potential moderators for the effectiveness of direct versus indirect strategies to enhance true self-knowledge are discussed. We then outline promising avenues for future research that include attempts to investigate the prevalence of self-alienation in clinical populations, and the effectiveness of strategies aimed at enhancing perceived true self-knowledge among clients experiencing stuckness.
Pendekatan Permainan Outbound Sirkuit Game Dalam Meningkatkan Kematangan Emosional Dan Spitual Melalui Pembelajaran Penjas Pada Siswa Smp N 1 Sumowono
Authors: Pratama Naufal Yoga , Hudah Maftukin 
Published: August 2020

ABSTRAK
Outbound sirkuit game merupakan salah satu bentuk pembelajaran olahraga di alam terbuka untuk mengembangkan bakat dan minat siswa melalui permainan. Penelitian ini bertujuan untuk meningkatkan kematangan emosional dan spiritual melalui pembelajaran aktivitas outbound.
Penelitian ini merupakan penelitian eksperimen dengan desain penelitian one group pretest-posttest design. Populasi dalam penelitian ini adalah siswa kelas VIIID SMP N 1 Sumowono dengan jumlah 30 siswa. Sampel dalam penelitian ini menggunakan teknik purposive sampling dengan jumlah 20 siswa. Intsrumen yang digunakan dalam penelitian ini adalah melalui angket permainan outbound. Teknik analisis data menggunakan uji-t melalui uji prasyarat uji normalitas dan uji homogenitas.
Hasil penelitian menunjukkan bahwa pada siklus I rata-rata persentase kematangan emosional dan spritual anak adalah 67,13% berada pada katagori rendah, sedangkan terjadi peningkatan pada siklus II menjadi 88,54% dengan katagori sedang, hal tersebut menandakan bahwa terdapat peningkatan rata- rata persentase kematangan emosional dan spiritual anak kelas VIIID sebesar 21,41%. Jadi penerapan metode outbound sirkuit game dapat meningkatkan kematangan emosional dan spiritual anak kelas VIIID semester II tahun pelajaran 2019/2020.

Kata kunci : Permainan outbound sirkuit game, Kematangan Emosional, Spiritual
The Effect of Circuit Training ond Speed, Agility and Endurance on UKM Futsal Male Players in Universitas PGRI Semarang
Authors: Muzaki Reiza , Maliki Osa , Kusuma Bertika 
Published: August 2020

Penelitian ini menggunakan desain penelitian one group pretest-posttest design. Sampel dalam penelitian ini adalah UKM futsal putra Universitas PGRI Semarang dengan jumlah 15 pemain, diambil menggunakan teknik purposive sampling. Instrumen yang digunakan adalah tes kecepatan menggunakan sprint 30 meter, kelincahan menggunakan illinois agility run test dan daya tahan menggunakan multistage fitness test. Teknik analisis data menggunakan uji-t melalui uji prasyarat uji normalitas dan uji homogenitas. Hasil penelitian pretest dan postest dengan uji beda (t-tes) menunjukan kecepatan diperoleh nilai t-hitung (10,379) > t-tabel (2,145), kelincahan diperoleh nilai t-hitung (5,162) > t-tabel (2,145) dan daya tahan diperoleh nilai nilai t-hitung (14,008) > t-tabel (2,145) sehingga hipotesis diterima dengan taraf signifikansi 0,00 < 0,05. Berdasarkan hasil penelitian dapat disimpulkan bahwa 1) Ada pengaruh latihan sirkuit terhadap kecepatan pemain UKM futsal putra di Universitas PGRI Semarang. 2) Ada pengaruh latihan sirkuit terhadap kelincahan pemain UKM futsal putra di Universitas PGRI Semarang. 3) Ada pengaruh latihan sirkuit terhadap daya tahan pemain UKM futsal putra di Universitas PGRI Semarang
Efficacy of Pneumococcal Polysaccharide Conjugate Vaccine (13-valent, Adsorbed) in Patients with Systemic Juvenile Idiopathic Arthritis Treated with Genetically Engineered Biologic Drugs (Tocilizumab or Canakinumab): Prospective Cohort Study
Authors: Alexeeva Ekaterina I. , Vankova Dariya D. , Dvoryakovskaya Tatyana M. , Isaeva Ksenia B. , Denisova Rina V. , Mamutova Anna V. , Chomakhidze Aleksandra M. , Radygina Tatyana V. , Zubkova Irina V. , Tkachenko Natalia E. , Fetisova Anna N. , Lomakina Olga L. , Orlova Yanina O. , Kurdup Mariya K. , Gautier Marina S. , Krekhova Elizaveta A. , Shingarova Meyri S. , Galkina Olga P. 
Published: August 2020

Background. Immunological potency of 13-valent pneumococcal vaccine (PCV-13) in children with systemic juvenile idiopathic arthritis (SJIA) is still unstudied. Estimates of the genetically engineered biologic drugs (GEBD) effects on pneumococcal vaccination results also remain controversial.Objective. The aim of the study was to explore the PCV-13 efficacy in patients with SJIA and who is on treatment with monoclonal antibodies against interleukin 6 receptor (tocilizumab) and interleukin 8 receptor beta (canakinumab).Methods. The study included patients under the age of 18 with SJIA in remission or active form of disease vaccinated with PCV-13. The vaccine was administered in single dose of 0.5 ml intramuscularly in patients on treatment with GEBD or 3 weeks before GEBD administration for the first time (for patients with active disease). Vaccination was considered effective at achievement of the minimum protective level of antibodies to capsular polysaccharide of pneumococcus (anti-SPP IgG; ≥ 7 U/ml) or increase of anti-SPP IgG level ≥ 2 times in 4 weeks after vaccination. The anti-SPP IgG levels were measured with enzyme immunoassay.Results. The study included 53 patients (27 girls) in remission of SJIA and 25 (16 girls) in active disease. Median age was 13.3 and 10.8 years respectively. Tocilizumab/canakinumab was administrated in 43/10 and 18/7 patients respectively. Minimum significant anti-SPP IgG level and two-fold increase in anti-SPP IgG level were recorded in 49/53 (92%) and 32/53 (60%) patients with SJIA in remission, as well as in 22/25 (88%) and 18/25 (72%) patients in active disease respectively. PCV-13 immunological potency in patients with SJIA in remission and in active disease (in those who were initially administrated and who did not receive GEBD) did not differ.Conclusion. PCV-13 vaccination allows to achieve protective antibodies level in most of the patients with SJIA in children population regardless of the disease stage and the history of GEBD administration.
Evolution of Mixed Connective Tissue Disease in 7 Years Old Child: Clinical Case
Authors: Makarova Tamara P. , Vakhitov Khakim M. , Sabirova Dina R. , Sadykova Dinara I. , Khusnutdinova Liliya R. , Firsova Natalya N. , Kucheryavaya Anna A. 
Published: August 2020

Background. Mixed connective tissue disease (Sharp syndrome) is the rare chronic autoimmune pathology combining various features of systemic lupus erythematosus, systemic scleroderma, rheumatoid arthritis, dermatomyositis and high antibody titer to nuclear ribonucleoprotein. The mixed connective tissue disease may evolve into other systemic diseases over time. Description of any cases of mixed connective tissue disease and its evolution in Russian patients has not been published previously.Clinical Case Description. The results of observations of the child with clinical and immunological signs of the mixed connective tissue disease followed by the progression of systemic scleroderma symptoms and development of Sjogren's syndrome in the short period of time are presented in the article. Improvement (such as pain attenuation, increase in volume of movements in affected joints, decrease of Raynaud syndrome manifestations duration) was observed on treatment (methotrexate 10 mg/week with subsequent addition of prednisolone 0.75 mg/kg/day).Conclusion. Timely diagnostics of clinical signs of the systemic diseases debut is crucial for correct patient routing and for achieving of disease improvement.
Análisis prospectivo de la industria de desarrollo de software en Colombia
Authors: Piña Taborda Jessica , Castaño Ospina Diana Marcela , Hernández Díaz Leonardo Enrique , Garro Torres Juan David 
Published: August 2020

<p>El propósito de esta investigación es identificar estrategias encaminadas a fortalecer la industria de desarrollo de software en Colombia; para lograr eso se utilizó el método francés de Michael Godet del análisis estructural prospectivo, y así se obtuvo una serie de tendencias con sus respectivas variables y comportamientos de las cuales se analizan el top 10 de mayor impacto. De este análisis se encontró que las empresas colombianas poseen la ventaja de ser veloces, agiles y eficientes para atender los rápidos, constantes y críticos cambios en todo el ciclo de vida del software. </p>
Participação das capitais dos estados brasileiros no financiamento do esporte e do lazer
Authors: Santos Edmilson Santos dos , Carvalho Maria José , Da Cunha Bastos Flavia , Starepravo Fernando Augusto 
Published: August 2020

Problema: as capitais dos Estados brasileiros apresentam as melhores condições para experimentarem a autonomia política garantida pela Constituição, pois mostram uma dinâmica econômica diferenciada. Objetivo: analisar os investimentos das capitais brasileiras na Função Desporto e Lazer (FDL) de 2002 a 2011 através das variáveis: tempo de adesão, volume de gasto, percentual da receita e gasto per capita. Método: o presente estudo caracteriza-se por ser descritivo de cunho exploratório, as informações foram capturadas diretamente do website do Tesouro Nacional. Ali foi possível perceber um comportamento regional na capacidade de gasto das capitais. Resultados: os Estados das regiões Sul e Sudeste apresentam condições muito mais favoráveis para garantirem a adesão, o volume de investimento e o percentual da receita comprometida com a Função Desporto e Lazer (FDL). Desconhecemos os motivos que levam a esse comportamento. Nesse sentido, uma segunda geração de investigação deve ser capaz de identificar as variáveis que ajudam a produzir esse resultado.
Effectiveness of Milieu Therapy in reducing conflicts and containment rates among schizophrenia patients
Authors: Bhat Sandhya , Rentala Sreevani , Bevinahalli Nanjegowda Raveesh , Belsiyal Chellappan Xavier 
Published: August 2020

Objective. To evaluate effectiveness of Milieu Therapy in reduction of conflict and containment rates among schizophrenia patients.Methods. This study utilized quasi experimental non-equivalent control group pre-post design. One hundred schizophrenia patients admitted in acute psychiatric wards were non-randomly assigned to either of the experimental (n=50) or control group (n=50). The experimental group received both milieu therapy and routine hospital treatment. The Milieu Therapy intervention Included environmental modification and structuring ward activities, establishing effective interaction with patient, and teaching caregivers on managing conflict behavior of patient. The control group received only routine treatment in the hospital. Outcome measures on conflict and containment rates were evaluated for both the groups at baseline and at 2nd, 3rd and 15th day. The Patient–Staff Conflict Checklist Shift Report (PCC-SR) was used to collect information about rates of conflict and containment.Results. Compared with control group, the experimental group participants showed decrease in aggressive behavior, self-harm behavior and general rule breaking behavior at baseline and 2nd, 3rd and 15th day (F=4.61, p<0.004, η2=0.04; F=11.92, p<0.001, η2=0.11; F=6.94, p<0.001, η2=0.06) over seven days interval.Conclusion. The present study findings provided evidence for the effectiveness of integrating Milieu Therapy in psychiatric acute wards in reducing conflict behaviors among schizophrenia patients. Milieu therapy should be considered as an integral part of psychiatric care settings in these patients. How to cite this article: Bhat S, Rentala S, BN Raveesh, Chellappan XB. Effectiveness of Milieu Therapy in reducing conflicts and containment rates among schizophrenia patients. Invest. Educ. Enferm. 2020; 38(1):e06.
Burnout among nursing students: a mixed method study
Authors: Quina Galdino Maria José , Brando Matos de Almeida Laio Preslis , Ferreira Rigonatti da Silva Luiza , Cremer Edivaldo , Rolim Scholze Alessandro , Trevisan Martins Júlia , Fernandez Lourenço Haddad Maria do Carmo 
Published: August 2020

Objective. Investigate the burnout syndrome among undergraduate students in nursing. Methods. Explanatory sequential mixed method study conducted at a public university in Brazil. Of the 119 nursing students, 114 consented to participate and answered a questionnaire composed of sociodemographic, academic variables, and the Maslach Burnout Inventory - Student Survey, which were analyzed by multiple linear regression. The participants of the quantitative phase with the indicative / risk of burnout were interviewed individually (n=21) to provide an in-depth understanding of the students' experiences regarding the dimensions of the syndrome, whose statements were analyzed by the Collective Subject Discourse. Results. The prevalence of burnout syndrome was 10.5% among the surveyed. The more advanced the school year, the higher were the exhaustion (p=0.003), depersonalization (p<0.001) and low academic effectiveness (p=0.012) scores. Students with a higher workload of assignments also had higher scores of exhaustion (p=0.001), depersonalization (p<0.001) and academic (in)effectiveness (p=0.042). Dissatisfaction with the course was related to higher exhaustion (p=0.049) and depersonalization (p=0.001). The collective speeches showed the daily demands of the course, considered as intense, producing overload and exhaustion, which produced symptoms of physical and mental illness. Thus, there was the student's distancing from the course activities, as a defensive attitude, which culminated in feelings of incompetence and frustration. Conclusion. The occurrence of burnout syndrome dimensions among nursing students was related to the activities of academic daily life. It is urgent to invest in health promotion and prevention actions of these individuals in the university context.How to cite this article: Galdino MJQ, Almeida LPBM, Silva LFR, Cremer E, Scholze AR, Martins JT, et al. Burnout among nursing students: a mixed method study. Invest. Educ. Enferm. 2020; 38(1):e07.
Web-based health Information Seeking and eHealth Literacy among College students. A Self-report study
Authors: KHademian Fatemeh , Arshadi Montazer Mahsa Roozrokh , Aslani Azam 
Published: August 2020

Objective. This study aimed to assess web-based health information seeking and eHealth literacy among Iranian college students. Methods. The study was conducted in five colleges of the Shiraz University of Medical Sciences in Iran during 2018. The data were collected by a researcher-made questionnaire consisting of seven questions on a 4-point Likert-type scale, with scores ranging from 7 to 28. These questions were: ′I know how to use the Internet to answer my questions about health′, ′I think there is enough information about health-related issues on the Internet′, ′I know the vocabulary used in health issues on the Internet′, ′I can tell high-quality health resources from low-quality health resources on the Internet′, ′I know how to use the health information I find on the Internet to help me′, ′I feel confident in using information from the Internet to make health decisions′, and ′Searching for health-related information on the Internet will increase my knowledge in this field′. High eHealth literacy level is defined as above the total mean score and low eHealth literacy level is defined as lower than the total mean score. Results. In all, 386 college students participated in the study. The results showed that the mean score of eHealth literacy was 19.11 out of 28; 205 participants (54.4%) had low eHealth literacy. In addition, the students used the Internet to search for information regarding diseases symptoms (70%), physical illnesses (67.1%), existing treatments (65%), and diagnosis (63.1%). Conclusion. The results showed that participants in this study usually searched for illnesses, symptoms, and treatments after they got sick and paid little attention to other aspects related to integral health.How to cite this article: KHademian F, Roozrokh M, Aslani A. Web-based health Information Seeking and eHealth Literacy among College students. A Self-report study. Invest. Educ. Enferm. 2020. 38(1):e08.
Education and Health: A Care Bond. School-Nursing Model for Colombia
Authors: Ferro Carvajalino María Clemencia , Fuentes Ramírez Andrea , Chinchilla Salcedo Tania Catalina , Sánchez Herrera Beatriz 
Published: August 2020

Objective. To describe the construction and validationprocess of a Model of professional practice of schoolnursing for Colombia.
Methods. Study under theapproach of “methodological research in nursing” carriedout by the Colombian network of school nursing, withthe participation of 26 nurses from different institutionsin a research developed in three stages: revision ofantecedents, identification and prioritizing of assumptionsto construct the model, and validation of the preliminaryproposal with the participants and with a group of experts.
Results. The study presents the components that werepart of the construction of the model of professionalpractice of school nursing for Colombia, which includesthe four meta-paradigmatic elements of this professionaldiscipline: the receptor of care, the context, nursing, andhealth, as well as the prioritized assumptions that indicatehow these elements interact in achieving the student´s wellbeing and that of the education community. It includes the report from a focalvalidation group with the participants in which they summarize as education andhealth: a care bond, and the concept by experts on such.
Conclusion. The Model of professional practice of school nursing for Colombia: education and health:a care bond, constructed in participative manner with nurses experts in the fieldand validated with theoretical experts complies with the international guides forthe design of this type of theoretical construction and permits guiding the caregoals of students, maintain the autonomy of the nurses and their interprofessionalparticipation in this field.