bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel insights into pathophysiology and therapeutic possibilities reveal further differences between AQP4-IgG- and MOG-IgG-associated diseases
Authors: Mader Simone , Kümpfel Tania , Meinl Edgar 
Published: April 2020

Purpose of reviewThis review summarizes recent insights into the pathogenesis and therapeutic options for patients with MOG- or AQP4-antibodies.Recent findingsAlthough AQP4-IgG are linked to NMOSD, MOG-IgG-associated diseases (MOGAD) include a broader clinical spectrum of autoimmune diseases of the central nervous system (CNS). Details of membrane assembly of AQP4-IgG required for complement activation have been uncovered. Affinity-purified MOG-IgG from patients were shown to be pathogenic by induction of demyelination when the blood--brain barrier (BBB) was breached and by enhancement of activation of cognate T cells. A high-affinity AQP4-IgG, given peripherally, could induce NMOSD-like lesions in rats in the absence of BBB breach. Circulating AQP4-specific and MOG-specific B cells were identified and suggest differences in origin of MOG-antibodies or AQP4-antibodies. Patients with MOG-IgG show a dichotomy concerning circulating MOG-specific B cells; whether this is related to differences in clinical response of anti-CD20 therapy remains to be analyzed. Clinical trials of AQP4-IgG-positive NMOSD patients showed success with eculizumab (preventing cleavage of complement factor C5, thereby blocking formation of chemotactic C5a and membrane attack complex C9neo), inebilizumab (depleting CD19 + B cells), and satralizumab (anti-IL-6R blocking IL-6 actions).SummaryNew insights into pathological mechanisms and therapeutic responses argue to consider NMOSD with AQP4-IgG and MOGAD as separate disease entities.
Coronavirus PPE: a positive pressure hood assembled from ubiquitous, low-cost materials
Authors: Crawford Mark 
Published: April 2020

AbstractA positive pressure protective hood system was purposefully constructed only from materials commonly found worldwide, including bendable aluminum mesh, elastic head straps, velcro tape, a plastic sheet, a furnace filter and two computer central processing unit (CPU) cooling fans. The practical advantages of this system are that the materials are readily available in the inventories of most electronics and hardware outlets, ease of assembly (particularly if choosing to employ 3D printing for the fan enclosure and/or making several units at once with a defined workflow), and high probability of the materials being available in current or prospective personal protective equipment (PPE)-deplete regions. An experiment with identical fire detectors showed adequate inner isolation of the hood prototype from paper combustion particulates, which have a size range slightly smaller than putative coronavirus aerosols, for at least 90 seconds. The theoretical advantages of this system include significant reduction in healthcare provider exposure to coronavirus-containing respiratory fomites, respiratory droplets and aerosols (vs. traditional static masks and shields) during high risk procedures such as endotracheal intubation or routine care of an upright and coughing patient. Additionally, the assembly eliminates contact exposure to coronavirus fomites due to whole-head coverage from a hood system.
Heparin therapy improving hypoxia in COVID-19 patients - a case series
Authors: Negri Elnara Marcia , Piloto Bruna Mamprim , Morinaga Luciana Kato , Poyares Jardim Carlos Viana , El-Dash Lamy Shari Anne , Ferreira Marcelo Alves , D’Amico Elbio Antonio , Deheinzelin Daniel 
Published: April 2020

ABSTRACTINTRODUCTIONElevated D-dimer is a predictor of severity and mortality in COVID-19 patients and heparin use during in-hospital stay has been associated with decreased mortality. COVID-19 patient autopsies have revealed thrombi in the microvasculature, suggesting intravascular coagulation as a prominent feature of organ failure in these patients. Interestingly, in COVID-19, pulmonary compliance is preserved despite severe hypoxemia corroborating the hypothesis that perfusion mismatch may play a significant role in the development of respiratory failure.METHODSWe describe a series of 27 consecutive COVID-19 patients admitted to Sirio-Libanes Hospital in São Paulo-Brazil and treated with heparin in therapeutic doses tailored to clinical severity.RESULTS AND DISCUSSIONPaO2/FiO2 ratio increased significantly over the 72 hours following the start of anticoagulation, from 254(±90) to 325(±80), p=0.013, and 81% of the patients were discharged home within a mean time of 11.4 (±7.9) days. Most mechanically ventilated patients (67%) were extubated within 12.5(± 5.7) days. There were no bleeding complications or fatal events.Even though this uncontrolled case series does not offer absolute proof of DIC as the underlying mechanism of respiratory failure in COVID-19, patient’s positive response to tailored dose heparinization contributes to the understanding of the pathophysiological mechanism of the disease and provides valuable information for the treatment of these very sick patients while we await the results of further prospective controlled studies.
Prevent the resurgence of infectious disease with asymptomatic carriers
Authors: Zhang Zhechun 
Published: April 2020

AbstractAfter reaching the peak of the COVID-19 outbreak, many regions are in search of a reopening plan that would minimize resurgence. Here we show to prevent resurgence local governments need to estimate how early and how many COVID-19 cases can be detected. It is safe to end social distancing if the majority of cases are detected early in the infection window. If cases are detected later, a 2-layer quarantine may be necessary to prevent resurgence. If fewer cases are detected, community events, schools, and large businesses may need to remain in virtual mode. Our results demonstrate that detecting more cases earlier is essential for preventing COVID-19 resurgence.
“Catechol-O-methyltransferase gene Val158Met polymorphism and prostate cancersusceptibility”
Authors: Kumar Pradeep , Rai Vandana 
Published: April 2020

AbstractProstate cancer is one of the most common and a serious malignancy of males and it is well reported that estrogen plays a pivotal role in prostate carcinogenesis. Catechol-O - methyltransferase (COMT) catalyzes the inactivation of estrogens. Several studies have investigated the association of COMT gene Val158Metpolymorphism with prostate cancer, but results were inconsistent and inconclusive. Hence, to assess this association, we performed a meta-analysis of all published case-control studies. Pubmed, Springer link, Google Scholar, Elsevier and Springer link databases were searched for case-control studies. Odds ratios (ORs) with 95% confidence intervals (CIs) was used as association measure. Statistical analysis was performed with the software program MIX and MetaAnalyst. In the current meta-analysis, 11 case control studies with 3381 prostate cancer cases and 3,276 healthy controls were considered. The results indicated no significant association between COMT Val158Met polymorphism and prostate cancer risk using allele contrast, co-dominant and homozygote models (allele contrast: OR= 0.92; 95% CI 0.85 to 0.98=; p= 0.02; co-dominant: OR=0.81; 95% CI= 0.85 to1.07; p= 0.46; homozygote: OR= 0.81; 95% CI= 0.70 to 0.95, p= 0.008), but showed significant association with dominant and recessive models (dominant: OR 1.18=; 95% CI= 1.03 to1.34; p= 0.01; recessive: OR= 1.54; 95% CI= 1.1 to 2.07; p = 0.003). In subgroup analysis meta-analysis using recessive genetic model showed significant association between COMT Val 158Met polymorphism and prostate cancer risk in both Asian and Caucasian populations. In conclusion, results of present meta-analysis supports that the COMT Val158Met polymorphism is risk factor for prostate cancer.
A patent-based method for monitoring the development of technological innovations based on knowledge diffusion
Authors: Liu Wei , Tan Runhua , Li Zibiao , Cao Guozhong , Yu Fei 
Published: April 2020

PurposeThe purpose of this paper is to investigate the diffusion patterns of knowledge in inspiring technological innovations and to enable monitoring development trends of technological innovations based on patent data analysis, thus, to manage knowledge wisely to innovate.Design/methodology/approachThe notion of knowledge innovation potential (KIP) is proposed to measure the innovativeness of knowledge by the cumulative number of patents originated from its inspiration. KIP calculating formula is regressed in forms of two specific diffusion models by conducting a series of empirical studies with the patent-based indicators involving forward and backward citation numbers to reveal knowledge managing strategies regarding innovative activities.FindingsTwo specific diffusion models for regressing KIP formula are compared by empirical studies with the result indicating the Gompertz model has higher accuracy than the Logistic model to describe the developing curve of technological innovations. Moreover, the analysis of patent-based indicators over diffusion stages also revealed that patents applied at earlier diffusion stages normally has higher forward citation numbers indicating higher innovativeness meanwhile the patents applied at the latter stages usually requiring more knowledge inflows observed by their larger non-patent citation and backward citation amounts.Originality/valueAlthough there is a large body of literature concerning knowledge-based technological innovation, there still room for discussing the mechanism of how knowledge diffuses and inspired knowledge. To the best of authors' knowledge, this study is the first attempt to quantitate the innovativeness of knowledge in technological innovation from the knowledge diffusion perspective with findings to support rational knowledge management related to innovation activities.
Influence of hydrocolloids on quality characteristics, functionality and microstructure of spinach puree–enriched instant noodles
Authors: Shere P.D. , Sahni Prashant , Devkatte A.N. , Pawar V.N. 
Published: April 2020

Purpose
Noodles are good vehicles for the enrichment and can be enriched with vegetable purees. However, this enrichment can alter quality attributes of noodles with resultant effect on its sensorial attributes. The purpose of this paper is to study the effect of addition of different hydrocolloids on the microstructural and quality characteristics of instant noodles enriched with spinach puree.

Design/methodology/approach
Preliminary trials were carried out for the standardization level of addition of spinach puree in noodle formulation. Carboxymethyl cellulose (CMC) and guar gum were added in the noodle formulation at 0.25, 0.5 and 0.75 per cent level of incorporation. The effect of addition of hydrocolloids was evaluated on the cooking quality, sensory attributes, texture characteristics and microstructure of the noodles.

Findings
The most acceptable ratio for the formulation of the noodles was found to be 40 g spinach puree per 100 g refined wheat flour. Addition of hydrocolloids resulted in the increase in the cooking time, cooking weight, water absorption and swelling index. Significant decrease in the cooking loss was observed with the increase in the level of CMC (from 7.4 to 6.1 per cent) and guar gum (from 7.4 to 7 per cent). Addition of CMC and guar gum up to 0.5 per cent and 0.25 per cent, respectively, improved the texture, overall acceptability and mouthfeel attributing to complimentary interaction between starch, fibre and hydrocolloids observed at microstructural level; however, further increase in the level of incorporation resulted in stickiness and sliminess in the noodle strands.

Practical implications
It is found that 0.5 per cent CMC and 0.25 per cent guar gum can be used for the enhancement of quality characteristics of the spinach puree enriched noodles.

Originality/value
Intervention of incorporation of hydrocolloids in spinach puree–enriched instant noodles delivers healthy and nutritious product without compromising on its sensorial and quality attributes.
Multiple meta-assessment measures of a quality process: toward institutional effectiveness
Authors: Pham Nhung Thi Tuyet 
Published: April 2020

Purpose
The purpose of this study is to share quality process experience from a US comprehensive university to use both direct (participation rate and assessment quality) and indirect assessment measures (assessment survey) to evaluate the quality process.

Design/methodology/approach
A mixed method design was used to evaluate the quality process. The qualitative design used thematic analysis to find the common themes from the assessment survey. The quantitative design included reliability and internal consistency for the survey and inter-rater reliability for the peer review.

Findings
Findings indicated that participation rate and assessment quality improved over the years. Faculty provided positive feedback about assessment website, the peer review process and feedback but negative perspectives on the assessment management software and heavy workload on assessment activities. The researcher shared the actions made based on three-year assessment results, especially how leaders have used it to align with planning and budgeting to close the institutional effectiveness loop.

Research limitations/implications
This research had two limitations. The inter-rater reliability of the peer review was not high and the number of peer review reports in two years were so different, so the results could not be checked for statistical significance.

Practical implications
The meta-assessment results could have important implications for other universities to improve the quality process.

Originality/value
There have been limited studies on using both direct and indirect assessment measures to evaluate the quality process. This study uses multiple measures to provide accurate results for administrators’ decision-making in resource allocation.
A case of foreign body granuloma caused by ‘Bong‐chim’ at the site of postherpetic neuralgia
Authors: Seol Jung Eun , Cho Gyeong Je , Park So Hee , Kim Hyojin 
Published: April 2020

AbstractForeign body granuloma is a potential adverse effect of acupuncture and usually occurs as an inflammatory reaction to foreign bodies that are accidentally or intentionally injected. This case presents a foreign body granuloma caused by honeybee acupuncture at the site of postherpetic neuralgia and highlights the need for caution and awareness of the side effects of acupuncture‐related procedures.
An audit of oral administration of Angusta® (misoprostol) 25 µg for induction of labor in 976 consecutive women with a singleton pregnancy in a university hospital in Denmark
Authors: Helmig Rikke B. , Hvidman Lone E. 
Published: April 2020

AbstractIntroductionInduction of labor (IOL) is used to improve the outcome of pregnancy for mother and child. Since 2013, oral misoprostol has been used for IOL at Aarhus University Hospital, Denmark. The purpose of the present paper is to describe our experience of the use of a new, 25‐µg misoprostol tablet commercially manufactured for the purpose of IOL regarding efficacy and outcome for mother and neonate in both an inpatient and an outpatient regimen.Material and methodsWe performed an audit from 1 April 2016, including data on all IOL in women with singleton pregnancies until 1000 consecutive women were registered. Data from 976 consecutive women with gestational age ≥37+0 weeks induced in accordance with the “Aarhus protocol” were included in the present analyses. All inductions were by oral misoprostol. Outpatient induction is standard procedure in low‐risk pregnancies, that is, pregnancies with a healthy mother and no signs of placental insufficiency. In the outpatient IOL, the first dose of misoprostol is administered after a normal cardiotocography registration at the hospital. Subsequent doses are taken at home according to a predefined regimen. Following delivery, data on baseline variables and outcome variables for the mother and neonate were retrieved from the medical records.ResultsIn 71.9% of cases, the women were induced in an outpatient regimen. Delivery within 24 hours was achieved in 38.8% of women (nulliparous 32.3%, multiparous 50.9%) and within 48 hours in 70.1% (nulliparous 66.2%, multiparous 77.2%). Hyperstimulation during induction occurred in 0.6%. The mode of delivery was spontaneous vaginal in 75.5% of cases. The cesarean section rate was 14.9% (nulliparous 20.7%, multiparous 4.1%). Apgar <7 at 5 minutes and pH <7.0 in the umbilical artery was seen in 0.9% and 0.7%, respectively.ConclusionsInduction of labor by a commercially produced low‐dose (25 µg) misoprostol tablet for oral induction according to the “Aarhus protocol” is feasible in an outpatient as well as an inpatient regimen. Delivery was achieved within 48 hours for 70.1% of women. Few adverse events were seen; however, the audit was underpowered for safety.
Front Cover
Authors: Tu Chaofeng , Wang Ying , Nie Hongchuan , Meng Lanlan , Wang Weili , Li Yong , Li Dongyan , Zhang Huan , Lu Guangxiu , Lin Ge , Tan Yue‐Qiu , Du Juan 
Published: April 2020

AbstractThe cover image is based on the Short Report An M1AP homozygous splice‐site mutation associated with severe oligozoospermia in a consanguineous family by Chaofeng Tu and Ying Wang et al., https://doi.org/10.1111/cge.13712.
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COVID‐19 and the Canadian cattle/beef sector: Some preliminary analysis
Authors: Rude James 
Published: April 2020

AbstractCanada's cattle/beef sector has already weathered a shock after a 2003 case of BSE resulted in closed borders and industry restructuring. Now, the sector has to adjust to similar shocks due to COVID‐19. This paper examines the supply chain from the consumer up to the cow–calf producer by considering consumer reactions, labor market constraints, and supply response. A quarterly market model of North American cattle and beef markets is used to examine price and revenue impacts associated with the market disruptions. Depending on the scenario, there is considerable price and revenue suppression at all levels of the market.
Oviposition preferences and antennal size in carrion flies
Authors: Pang Xiu’nan , Liu Genting , Wang Qike , Elgar Mark A. , Zhang Dong 
Published: April 2020

AbstractCarrion‐feeding flies use odours emanating from the decomposing corpse as cues for oviposition and are described as generalists because the larvae feed on the corpses of diverse species. Whereas several features of the corpse may influence the oviposition choices of these flies, it is not known whether there is a preference for a particular species of corpse. We provided carrion flies with ovipositional (and feeding) choices in a field experiment, in which various odour sources were presented simultaneously. We found novel evidence of broadly consistent choices of carrion by flies from four families. Traps baited with decaying fish flesh captured the greatest number of individuals, whereas traps baited with decaying pig liver typically attracted the least. We also asked whether individuals captured in the various baits vary in antennal size, perhaps reflecting different capacities for odour detection. There was a trend for individuals of Lucilia sericata Meigen (Diptera: Calliphoridae) and the platystomatid collected from the traps baited with pig liver to have significantly larger antennae, whereas individuals of Muscina stabulans (Fallen) (Diptera: Muscidae) captured in traps baited with marine fish flesh had relatively longer antennae for their body size. Our data reveal a more nuanced pattern of oviposition behaviour in these generalist carrion flies, which may reflect differences in their preference of carrion with different nutrients, and in their capacity to detect particular odours.
Effect of smear layer deproteinization with HOCl solution on the dentin bonding of conventional and resin‐modified glass‐ionomer cements
Authors: Paing Soe Yu , Tichy Antonin , Hosaka Keiichi , Nagano Daiki , Nakajima Masatoshi , Tagami Junji 
Published: April 2020

The effect of smear layer‐deproteinizing pretreatment using hypochlorous acid (HOCl) on the micro‐shear bond strengths (μSBS) of conventional and resin‐modified glass‐ionomer cements (GIC) to dentin was investigated and compared with demineralizing pretreatment with polyacrylic acid (PAA). Three GICs: Fuji IX GP Extra (restorative conventional GIC), GC Fuji II LC EM (restorative resin‐modified GIC), and GC Fuji Luting EX (luting resin‐modified GIC), were used. One hundred fifty human molars were divided into groups (n = 10) according to the cements and dentin pretreatments; no pretreatment (control), 10 s PAA pretreatment, and HOCl pretreatment for 5, 15, or 30 s. After 24 h, μSBS was tested and the data were statistically analyzed using a two‐way ANOVA, followed by Tukey's post‐hoc test. HOCl pretreatment significantly increased μSBS of conventional GIC compared to the control group. For resin‐modified restorative GIC, 5 s HOCl deproteinization significantly increased μSBS, while longer application times did not. There was no significant difference between HOCl‐pretreated and control groups of resin‐modified luting GIC. PAA pretreatment increased the μSBS of all cements significantly. In conclusion, smear layer deproteinization with HOCl can enhance the dentin bonding of conventional GIC. However, the residual radicals may adversely affect the polymerization of resin‐modified GICs.
New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: A retrospective multicenter study
Authors: Lu Lu , Xiong Weixi , Liu Dan , Liu Jing , Yang Dan , Li Nian , Mu Jie , Guo Jian , Li Weimin , Wang Gang , Gao Hui , Zhang Yingying , Lin Mintao , Chen Lei , Shen Sisi , Zhang Hesheng , Sander Josemir W. , Luo Jianfei , Chen Shengli , Zhou Dong 
Published: April 2020

AbstractOur aim was to clarify the incidence and risk of acute symptomatic seizures in people with coronavirus disease 2019 (COVID‐19). This multicenter retrospective study enrolled people with COVID‐19 from January 18 to February 18, 2020 at 42 government‐designated hospitals in Hubei province, the epicenter of the epidemic in China; Sichuan province; and Chongqing municipality. Data were collected from medical records by 11 neurologists using a standard case report form. A total of 304 people were enrolled, of whom 108 had a severe condition. None in this cohort had a known history of epilepsy. Neither acute symptomatic seizures nor status epilepticus was observed. Two people had seizurelike symptoms during hospitalization due to acute stress reaction and hypocalcemia, and 84 (27%) had brain insults or metabolic imbalances during the disease course known to increase the risk of seizures. There was no evidence suggesting an additional risk of acute symptomatic seizures in people with COVID‐19. Neither the virus nor potential risk factors for seizures seem to be significant risks for the occurrence of acute symptomatic seizures in COVID‐19.