bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Linear Regression Approach for Strategic Decisions on Industrial Productivity under Limited Available Budget
Authors: Ojo Oluwaseun Oluwagbemiga , Oladapo David Ifeoluwa , Ajayeoba Abiola Olufemi , Akinnuli Basil Olufemi , Omotayo Temitayo Daniel 
Published: December 2020

Proper planning and improved productivity is highly desired in industrial settings to optimize the available resources when there is limited resources and to control excessive spending in time of surplus. Productivity is achievable by good levels of Materials, Time and Labor inputs which needs to be measured scientifically in order to maintain long run profit. This study explored processing data and incorporated Statistical Package for Social Science (SPSS) to find the relationship and predict the response of the available budget with the inputs of Materials, Time and Labor using Olam Cocoa Processing Industry, Nigeria as case study. The analyses were done using Multiple Linear Regression Model developed (i.e. ), it was discovered that the inputs of the selected strategic decisions collectively affected the response of the available budget with F-value of 88.48 but each of them cannot reduce or increase the amount of budget except for manpower which has 0.069 or 93.1 % significant effect on the available budget. Also, Coefficient of determination established a strong fitness of the relationship between the strategic decisions and the available budget with the value of 0.974 (or 97.4 %). It is recommended that the project manager should subject his decisions making into scientific measures rather than brainstorming so as to increase productivity in the company.
Socio-demographic Risk Factors in Depression among the Clergy in Nigeria
Authors: Solomon Enyidah Nonyenim , Micheal Osika Ubigh , Sokiprim Akoko 
Published: December 2020

Background: Depression poses a huge challenge on personal, professional, and social life of individuals. Studies on the prevalence of depression have largely been on the general population, using socio-demographic variables to explain it’s outcome. The clergy constitutes a special group of trained professionals on the vocation of care-giving, problem solving and spiritual healing. Information is scanty on the prevalence of depression among them and the contribution of socio-demographic risk factors on their mental health.
Objectives: This study seeks to determine the prevalence of depression among the clergy and impact of socio-demographic variables on their mental health.
Methods: 84 pastors of the Seventh-Day Adventist Church in southern Nigeria, were evaluated for depression using the 9-item patients health questionnaire (PHQ-9), which assesses vulnerability to depression, and a 27 item demographic and risk factor questionnaire which assessed the demographic variables. Using the statistical package for social sciences (SPSS-25.0), cross tabulation of variables of interest were obtained using x2 and t-test. Level of correlation of variables with depression was done by a bivariate correlation analysis.
Results: Out of the 84 pastors who consented to the study, 16 (19%) had depression, mean age of participants was 43.6yr, 72 (85.7%) were currently married, all the participants were educated, the mean year of service was 10 years and 45% had at least 3 children. There was no significant correlation between the socio-demographic variables and depression.
Conclusion: The study revealed a 19% prevalence rate for depression among the clergy and that the socio-demographic variables of age, marital status, level of education, number of children and year of service impacted positively on the mental health of the clergy.
Associations of Cerebrospinal Fluid Orexin‐A, Alzheimer Disease Biomarkers, and Cognitive Performance
Authors: Lu Ruijin , Shah Krish , Toedebusch Cristina D. , Hess Ashley , Richardson Rachel , Mignot Emmanuel , Schindler Suzanne E. , Benzinger Tammie L. S. , Flores Shaney , Hassenstab Jason , Xiong Chengjie , Morris John C. , Holtzman David M. , Lucey Brendan P. 
Published: February 2025

ABSTRACTObjectiveCerebrospinal fluid (CSF) orexin‐A has been suggested to be a biomarker of Alzheimer disease (AD). In both cognitively unimpaired healthy older adults and individuals with symptomatic AD, CSF orexin‐A is positively associated with CSF Aβ42, p‐tau181, and total tau (t‐tau) concentrations. However, a recent systematic review and meta‐analysis did not support differences in orexin‐A between AD and controls. In this study, we tested the association between CSF orexin‐A concentrations, AD biomarkers, and cognitive performance in older adults with and without symptomatic AD.MethodsTwo hundred and seventy community‐dwelling older adults underwent standardized cognitive assessments, sleep monitoring with a single‐channel electroencephalography test, one night of home sleep apnea testing, biofluid and imaging AD biomarker measurement within 1 year of sleep monitoring, and APOE genotyping. Plasma and CSF AD biomarkers were measured by immunoassay or mass spectrometry. CSF orexin‐A was measured by radioimmunoassay.ResultsCSF orexin‐A levels did not differ by amyloid positivity, cognitive status, or AD stage. However, CSF AD biomarkers (Aβ40, Aβ42, and t‐tau) were positively associated with CSF orexin‐A levels even after correction for multiple comparisons. CSF orexin‐A was not associated with any measure of cognitive performance.InterpretationThis study showed that CSF orexin‐A is associated with multiple CSF AD biomarkers, but not with AD pathology or cognitive performance. We hypothesize that this is due to similar mechanisms of production/release of these proteins with sleep–wake activity. Future studies measuring other forms of orexin peptides, such as orexin‐B, may provide evidence for orexin as a marker for AD.
Stabilized Intermediate Phase Via Pseudo‐Halide Anions Toward Highly Efficient and Light‐Soaking Stable Perovskite Solar Cells
Authors: Seo Jongdeuk , Shin Yun Seop , Lee Dong Gyu , Lee Jaehwi , Roe Jina , Son Jung Geon , Lee Woojin , Lee Yeonjeong , Lee Dongmin , Song Ji Won , Lee Tae Kyung , Kim Dong Suk , Kim Jin Young 
Published: February 2025

AbstractLong‐term stability remains challenging due to persistent defects within the perovskite material, particularly at buried interfaces. Strategies to address these issues have focused on refining interfaces and managing residual lead iodide (PbI2), which impedes electron transport and compromises stability under prolonged light exposure. This study explores the impact of lead formate (PbFo2) treatment on SnO2 electron transporting layer (ETL) substrates and its subsequent influence on the performance of perovskite solar cells (PSCs). The carboxylate functionality of Fo− ions exerts multifaceted effects, influencing not only the electrical properties of the SnO2 ETL but also the morphological characteristics and crystallization mechanism of the overlying perovskite film. The ionized Fo− ions aid in forming bulk perovskite as intermediate phases during the perovskite crystallization. By stabilizing intermediate phases, their incorporation suppresses indiscriminate phase transitions from δ‐phase to α‐phase perovskite, ensuring the production of highly crystalline pure α‐phase perovskite with alleviated tensile strain throughout the perovskite film, particularly near the buried interface. Consequently, the strategy showcases enhanced performance with a power conversion efficiency (PCE) of 25.69% and enables a refined buried interface, devoid of residual PbI2, ensuring long‐term stability under continuous light‐soaking for 1,000 h. Overall, PbFo2 treatment stands as a pioneering approach poised to expedite commercialization.
Cyano‐Functionalized Hybrid Electrode‐Electrolyte Interphases Enabled by Cyano‐Substituted Tetrafluorobenzene Derivatives Additives for High‐Voltage Lithium Metal Batteries
Authors: Li Xin , Bai Yu , Jing Jiaxin , Ren Tao , Wang Zhenhua , Ma Jianmin , Sun Kening 
Published: February 2025

AbstractLithium metal batteries (LMBs) operating at high voltages are attractive for their energy storage capacity but suffer from challenges: cathode instability, electrolyte consumption, and lithium dendrite growth. Modulating the electrode/electrolyte interphase (EEI) with functional additives is a practical strategy. Herein, a cyano (‐CN)‐functionalized hybrid EEI strategy is proposed to develop electrolytes for high‐voltage Li||LiNi0.8Co0.1Mn0.1O2 (Li||NCM811) battery with ‐CN‐substituted tetrafluorobenzene derivatives (tetrafluorophthalonitrile (o‐TFPN), tetrafluoroisophthalonitrile (m‐TFPN)), and tetrafluoroterephthalonitrile (p‐TFPN)) as additives. The results demonstrate that the electrolyte‐containing additives, particularly o‐TFPN‐contained electrolyte, can derive a robust, and thermally stable cathode electrolyte interphase (CEI) enriched with LiF and ‐CN groups. Furthermore, the o‐TFPN‐contained electrolyte forms a stable solid electrolyte interface (SEI) with Li2O, LiF, and ‐CN. The ‐CN group generates electrostatic attraction, guiding Li+ flux, while LiF and Li2O with high ionic conductivity facilitate rapid Li+ deposition. The excellent EEI suppresses cathode degradation, electrolyte consumption, and dendrite formation. Therefore, the Li||NCM811 battery achieves stable performance over 200 cycles at 4.6 V, while the Li||Li symmetric cell stably cycles for over 350 h at a current density of 1 mA cm−2.
Trump Tariffs 2.0: Assessing the Impacts on US Distilled Spirits Imports
Authors: Muhammad Andrew 
Published: February 2025

ABSTRACTThe proposed 25% tariff on Mexico and Canada could have significant repercussions on US imports of distilled spirits. This study estimates US import demand across various spirit categories (e.g., tequila, whiskey) and assesses the potential impact of the proposed tariff. Findings project that imports could decline by more than $1.0 billion, potentially falling by as much as $1.4 billion, primarily due to a substantial decrease in tequila imports. Interestingly, even imports not subject to the tariffs are expected to decline due to the complementarities in importing. Despite the inelastic nature of demand, the results suggest that trade losses would exceed any revenue gains from the tariffs.
Maintenance Therapy in AML: What Is the Future Potential?
Authors: Goulart Hannah , Wei Andrew H. , Kadia Tapan M. 
Published: February 2025

ABSTRACTOver the last decade, there have been significant advancements in the treatment for patients with acute myeloid leukemia (AML) including the addition of novel, targeted agents to intensive or nonintensive chemotherapy regimens. However, despite this, the majority of patients will still ultimately relapse and long‐term survival remains poor. While the use of maintenance therapy has emerged as a potential strategy to maintain more durable remissions and improve overall survival, the optimal use of these therapies has not yet been clearly defined. In this review, we provide a comprehensive overview of the evolution of maintenance strategies in AML and present a commentary on the future of maintenance therapy, including the pressing, unmet needs in this field.
Frontline Therapy of AML in the Fit and Younger Population—Incorporating Molecularly Targeted Agents
Authors: Pratz Keith W. , Erba Harry P. 
Published: February 2025

ABSTRACTBackbone therapy for acute myeloid leukemia for younger adults has for 50 years been based on a combination of cytarabine and anthracycline. Over the past 10 years the addition of several targeted agents has been found to improve the outcomes of subsets of AML with particular molecular changes. In this review we will examine the data generated to date on the addition of agents targeting CD33, FLT3, IDH, and BCL2 to standard high intensity therapies. We will also review the potential for future studies evaluating the application of highly active lower intensity therapies developed in older adults to patients considered “fit for high intensity induction.” Lastly, we review the data around the role of stem cell transplant in the modern targeted era.
The Use of Antihypertensive Medication and In Vivo Alzheimer's Disease Pathology
Authors: Keum Musung , Byun Min Soo , Yi Dahyun , Ahn Hyejin , Jung Gijung , Jung Joon Hyung , Kong Nayeong , Lee Jun‐Young , Kim Yu Kyeong , Lee Yun‐Sang , Kang Koung Mi , Sohn Chul‐Ho , Lee Dong Young ,   for the KBASE Research Group
Published: February 2025

ObjectiveWe investigated whether the use of antihypertensive medication (AHM) is associated with in vivo Alzheimer's Disease (AD) pathologies in older adults with hypertension and examined if the effect differs by drug‐class and blood–brain barrier (BBB) permeability of the drug.MethodsThis cross‐sectional study recruited participants from the Korean Brain Aging Study for the Early Diagnosis and Prevention of Alzheimer's Disease. Participants comprised both cognitively normal and impaired older adults diagnosed with hypertension (n = 408). All participants underwent comprehensive clinical assessment and [11C] Pittsburgh Compound B positron emission tomography (PET) for measurement of cerebral β‐amyloid (Aβ) deposition. Additionally, a subset of participants (n = 120) was subjected to [18F] AV‐1451 PET to assess tau deposition.ResultsThe AHM group (n = 227) exhibited significantly lower Aβ deposition (B [SE] = −0.104 [0.037], p = 0.006) compared to the non‐AHM group (n = 181), even after controlling for age, sex, apolipoprotein E ε4‐positivity, vascular risk factors, and mean arterial blood pressure. Further analysis by AHM class showed an association between the use of renin‐angiotensin system inhibitors (RASi) and less Aβ deposition (B [SE] = −0.143[0.049], p = 0.004). No significant relationships were observed between the use of BBB‐permeable AHM and Aβ deposition. Additionally, associations between AHM use and tau deposition did not reach statistical significance.InterpretationOur findings suggest that AHM use may be associated with lower Aβ burden in older adults with hypertension. Further studies exploring the underlying mechanism, particularly related to RASi, may provide insights into new therapeutic targets for AD. ANN NEUROL 2025
Surface‐Confined Disordered Hydrogen Bonds Enable Efficient Lithium Transport in All‐Solid‐State PEO‐Based Lithium Battery
Authors: Fan You , Malyi Oleksandr I. , Wang Huicai , Cheng Xiangxin , Fu Xiaobin , Wang Jingshu , Ke Haifeng , Xia Huarong , Shen Yanbin , Bai Zhengshuai , Chen Shi , Shao Huaiyu , Chen Xiaodong , Tang Yuxin , Bao Xiaojun 
Published: February 2025

AbstractPolyethylene oxide (PEO)‐based electrolytes are essential to advance all‐solid‐state lithium batteries (ASSLBs) with high safety/energy density due to their inherent flexibility and scalability. However, the inefficient Li+ transport in PEO often leads to poor rate performance and diminished stability of the ASSLBs. The regulation of intermolecular H‐bonds is regarded as one of the most effective approaches to enable efficient Li+ transport, while the practical performances are hindered by the electrochemical instability of free H‐bond donors and the constrained mobility of highly ordered H‐bonding structures. To overcome these challenges, we develop a surface‐confined disordered H‐bond system with stable donor‐acceptor interactions to construct a loosened chain segments/ions arrangement in the bulk phase of PEO‐based electrolytes, realizing the crystallization inhibition of PEO, weak coordination of Li+ and entrapment of anions, which are conducive to efficient Li+ transport and stable Li+ deposition. The rationally designed LiFePO4‐based ASSLB demonstrates a long cycle‐life of over 400 cycles at 1.0 C and 65 °C with a capacity retention rate of 87.5 %, surpassing most of the currently reported polymer‐based ASSLBs. This work highlights the importance of confined disordered H‐bonds on Li+ transport in an all‐solid‐state battery system, paving the way for the future design of polymer‐based ASSLBs.
Prediction and Validation of Mechanical Flexibility in Molecular Crystals: Dispersion Interactions Dictate Bending
Authors: Singh Ashi , Rahman Atiqur , Mondal Srijan , Spackman Mark A , Iversen Bo B , Thomas Sajesh Pynadath 
Published: February 2025

Mechanically flexible crystals are a rapidly growing class of functional molecular materials. Typically, such flexible crystals are discovered by serendipity. Herein, we have predicted mechanical flexibility in a series of molecular crystals based on a structure screening approach that combines interaction topology and the presence of nitrile×××nitrile interactions – a supramolecular motif hitherto not associated with bending property. Further, we have experimentally validated plastic/elastic bending properties in a series of crystal structures thus predicted. However, four out of five of these crystals showed the bending direction along π∙∙∙π stacking despite the fact that the direction of strongest interaction anisotropy was rendered by the nitrile∙∙∙nitrile interaction motifs. This is contrary to the commonly perceived anisotropy model and underscores the dominant role of dispersion forces over the electrostatically stabilized motifs in dictating the bending phenomena in molecular crystals. The interaction energies of these motifs have been evaluated using accurate structures from X‐ray quantum crystallography. Analyses combining elastic tensors, interaction anisotropy indices, thermal expansion studies, and high‐pressure simulations quantify the relative roles of the nitrile∙∙∙nitrile motif and π∙∙∙π stacking in mechanical flexibility. Our results point to the possibility of expanding the realm of flexible molecular materials by predictive computational models.
Facilitating OH* Generation on Atomic Pd–Cu Dual Sites towards Efficient Glycerol Electrooxidation to Formate
Authors: Li Junjun , Zhang Yizhen , Zhang Liya , Zhou Qi , Yang Jiangrong , Fu Yu , Yu Le , Sun Yuanmiao , Li Zhenhua , Qin Yuchen , Yi Ding , Zhang Hui , Wang Dingsheng , Zhang Zhicheng 
Published: February 2025

AbstractThe electrocatalytic glycerol oxidation reaction (GOR) represents a mild and sustainable pathway to produce value‐added chemicals such as formate. However, the rational design and controlled synthesis of efficient catalysts to achieve highly selective C−C bond cleavage of glycerol towards formate remains a great challenge. Herein, atomic Pd doped Cu3N hollow nanocubes with Pd−Cu dual sites were prepared via the unique Kirkendall process, exhibiting superior electrocatalytic GOR activity and selectivity towards formate with a maximum Faraday efficiency of 91.6 %. In situ spectroscopic characterization and theoretical calculations reveal that Pd atoms located in partial Cu substituent sites could facilitate the generation of active *OH and enhance the adsorption of glycerol molecule on adjacent Cu sites, while Pd atoms located in Cu3N unit center could effectively reduce the energy barrier of C−C bond cleavage for the rate determining step. Our work provides new insights into the development of well‐defined dual‐site catalysts to boost glycerol electrooxidation to formate.
An Efficient and Eco‐Friendly Protocol for Synthesis of 2‐Substituted Benzimidazole and Quinoxaline Derivatives by Using Nanostructured Cu2O as Recyclable Catalyst
Authors: Kusuma Suman , Manjunath Hemavathi , Narayana Venkat V. , Torrejos Rey Eliseo , Norrrahim Mohd Nor Faiz , Jadhav Arvind H. 
Published: February 2025

ABSTRACTReconnoitre the use of earth‐abundant metals for an essential organic reaction was extremely provocative from an industrial vantage point. In this study, the fundamental and energy‐efficient co‐precipitation approach was employed to aid the Cu2O cubed nanostructured catalyst in the generation of benzimidazole and quinoxaline derivatives. The developed Cu2O cubed nanostructured catalyst was thoroughly evaluated by world‐class analytical and spectroscopic techniques. The Cu2O cube catalyst exhibited exceptional crystallinity, a cubic shape, a large specific surface area and uniformly distributed active sites on its surface. The obtained astounding structural and physico‐chemical characteristics successfully enabled the catalytic activity for the synthesis of benzimidazole and quinoxaline. The recognised vital structural and physical attributes substantially improved the catalytic activity for the production of benzimidazole and quinoxaline derivatives over mild reaction conditions. Employing a cubic Cu2O catalyst, diverse reaction parameters have been examined, encompassing the effects of catalyst dosage, temperature, time, solvent, yield and substrate scope. As a result, the designed catalyst was used to synthesise heterocyclic 2‐substituted benzimidazole and quinoxaline derivatives via the condensation of o‐phenylenediamine, aldehydes and 1,2‐diketone. The reported results showed 100% conversion in both aimed products, with 90% selectivity for 2‐substituted benzimidazole and 95% selectivity for quinoxaline derivatives, respectively. The obtained yield for 2‐substituted benzimidazole and quinoxaline derivatives was 85 and 98 at 60°C for 3 and 4 h, individually. The catalytic activity was fully based on the inherent properties of cubic Cu2O. On top of that, all synthesised compounds were structurally validated by 1H NMR, 13C NMR and mass spectrum data. Remarkably, the efficient cubic Cu2O catalyst demonstrated impressive recyclability for up to six consecutive cycles with minimal loss of its initial catalytic activity. The spent cubic Cu2O catalyst's characteristic results revealed evidence for its stable structural and physico‐chemical features. In addition, we endeavoured to propose and describe a plausible reaction mechanism utilizing the developed nanostructured Cu2O cubes for the synthesis of benzimidazole and quinoxaline derivatives.
Shape Memory Polymers With High Response Temperature and Application in Wellbore Stability
Authors: Liu Zhendong , Sun Tengfei , Li Gongrang , Xu Hai , Lv Jianren 
Published: February 2025

ABSTRACTThis study focuses on the preparation and characterization of high glass transition temperature shape memory polymers (HTSMP) for leak plugging applications. The HTSMP was synthesized through a curing reaction and characterized using FTIR spectroscopy, which confirmed the occurrence of a ring‐opening reaction resulting in the formation of hydroxyl groups. The glass transition temperature of HTSMP reached up to 136°C, and it maintained a modulus of over 10 MPa at 200°C. Shape memory performance tests showed that HTSMP samples exhibited a recovery rate ranging from 80% to 95%, with a higher recovery rate observed with increased curing agent content. In sealing performance tests, the addition of HTSMP‐1 significantly improved the plugging effect of conventional plugging agents, with a pressure‐bearing capacity of up to 9.28 MPa at elevated temperatures. These results demonstrate the potential of HTSMP in sealing applications, particularly for addressing fractured leakage in high‐temperature deep wells.
Genomic Evaluation of Recombination in Small Highly Inbred Beef Cattle Populations
Authors: Hay E. , Ling A. S. 
Published: February 2025

ABSTRACTMeiotic recombination is key for genetic diversity, but its dynamics are underexplored in small inbred beef cattle populations. This study examines recombination in closed beef cattle populations and identifies related genomic regions. Using genotypic data from 1020 Line 1 Hereford and 3420 Composite Gene Combination (CGC) cattle, recombination rates were estimated through offspring and progenitor haplotypes. The CGC composite displayed a higher recombination rate (27.24 events) than the Line 1 population (26.38 events), with reduced rates in Line 1 potentially due to extended homozygous segments. Recombination varied by autosome length, increasing with longer autosomes. A genome‐wide association study revealed novel genomic regions associated with recombination: significantly associated SNP markers were found on Bos taurus autosome (BTA) 1, 7, 13, 15, and 19 in the Line 1 population, and numerous others in the CGC population, indicating complex polygenic influences.