bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining quantitative analysis with an elliptic Fourier descriptor: A study of pottery from the Gansu-Zhanqi site based on 3D scanning and computer technology
Authors: WANG JIN , Qian wei , Chen guoke 
Published: August 2020

Abstract
Pottery is an important material in archaeological studies, and the accurate classification of pottery shapes largely depends on the experience and knowledge of archaeologists. In this thesis, pottery taken from the Gansu-Zhanqi site is used for sampling. Three-dimensional (3D) models of the pottery were obtained using 3D scanning, and a computer-assisted pottery typology was studied through quantitative analysis and elliptic Fourier analysis. This method, which can enhance and supplement the traditional methods of classifying pottery in archaeology and thereby enrich the parameters and breadth of pottery analysis, represents a new means for exploring and experimenting with objective classification and provides a new tool for traditional archaeological analysis methods.
Relationship of serum VITD3, HSCRP and HbA1c level in non diabetic patients referring to tertiary hospital
Authors: zare-mirzaie ali , mehdizadeh somayeh , babaheidarian pegah 
Published: August 2020

Abstract
Background: In diabetic patients high HbA1c is associated with high level of HSCRP and VITD3 deficiency could result in diabetes and high HbA1c level. The aim of this study was to determine the relation of HbA1c, HSCRP and vitamin D3 in healthy individuals who referred to Rasool Akram Hospital. Methods: In this cross sectional study, individuals who referred to our center between 2018 and 2019 for the measurement of HbA1c were classified to three groups based on the level of the HbA1c: <5, 5-5.6 and 5.7≤. Then the Serum level of HSCRP and vitamin D3 were measured and compared between these three groups.Results: In this study, 90 healthy individuals were studied. In subjects with BMI below 25, no significant difference in HSCRP level was seen in group with low and normal HbA1c, but group with high HbA1c has non-significant higher level of HSCRP rather than group with normal HbA1c. In subject with BMI higher than 25, group with high HbA1c and low HbA1c had non-significant higher level of HSCRP than group with normal HbA1c and in the subjects, no significance difference at serum level of vitamin D3 level has been identified between HbA1c groups. Conclusion: As immunomedulatory role of VitD3 is shown in many studies and low VitD3 could predispose people to diabetes independent of obesity, Conflicting results in various studies emerge an idea to mind that considering relation of other factors responsible in glucose metabolism such as insulin level, IGF-1, C-Peptide and VitD3 could be a better overview on vitD3 effect on glucose metabolism
Stereotactic body radiotherapy versus conventional/moderate fractionated radiation therapy with androgen deprivation therapy for unfavorable risk prostate cancer
Authors: Patel Sagar Anil , Switchenko Jeffrey , Fischer-Valuck Ben , Zhang Chao , Rose Brent , Chen Ronald , Jani Ashesh , Royce Trevor J 
Published: August 2020

Abstract
Background:Ultrahypofractionation using stereotactic body radiotherapy (SBRT) is an increasingly utilized technique for men with prostate cancer (PC). The comparative efficacy of SBRT plus androgen deprivation therapy (ADT) compared to fractionated radiotherapy (EBRT) plus ADT in higher-risk prostate cancer is unknown. Methods:Men >40 years old with localized PC treated with external beam radiation and concomitant ADT for curative intent between 2004-2016 were analyzed from the National Cancer Database. Patients who lacked ADT or risk stratification data were excluded. 558 men treated with SBRT versus 40,797 men treated with conventional or moderately hypofractionated EBRT were included. Patients were stratified by unfavorable intermediate (UIR) and high (HR) risk using NCCN criteria. Kaplan Meier and Cox proportional hazards were used to compare overall survival (OS) between RT modality, adjusting for age, race, and comorbidity index.Results:With a median follow up of 74 months, there was no difference in estimated 6-year OS between men treated with SBRT versus EBRT regardless of risk group. On multivariable analysis, there was no difference in risk of death for men treated with SBRT compared to EBRT (UIR: adjusted HR 1.09, 95% CI 0.68-1.74, p=.72; HR: adjusted HR 0.93, 95% CI 0.76-1.14, p=.51). On sensitivity analyses, when confining the cohort to men treated with NCCN-preferred dose fractionations, with no comorbidities, or <65 years old, there remained no survival difference between treatment groups for both UIR and HR.Conclusion: Within study limitations, we found no difference in survival between SBRT+ADT and standard of care EBRT+ADT for UIR or HR PC. These results support recent NCCN guideline updates, which include SBRT as a non-preferred option for higher risk men. Prospective validation would further strengthen the evidence basis behind these recommendations.
Evaluation of 18F-FDG PET/CT Images Acquired with a Reduced Scan Time Duration in Lymphoma Patients using the Digital Biograph Vision
Authors: Weber Manuel , Jentzen Walter , Hofferber Regina , Herrmann Ken , Fendler Wolfgang Peter , Rischpler Christoph , Umutlu Lale , Conti Maurizio , Costa Pedro Fragoso , Sra Miriam , Kersting David 
Published: August 2020

Abstract
Background: The superior accuracy and sensitivity of 18F-FDG-PET/CT in comparison to morphological imaging alone leads to an upstaging in up to 30 % of lymphoma patients. Novel digital PET/CT scanners might enable to reduce administered tracer activity or scan time duration while maintaining diagnostic performance; this might allow for a higher patient throughput or a reduced radiation exposure, respectively. In particular, the radiation exposure reduction is of interest due to the often young age and high remission rate of lymphoma patients.Methods: Twenty patients with (suspected) lymphoma (6 for initial staging, 12 after systemic treatment, 2 in suspicion of recurrence) sequentially underwent 18F-FDG-PET/CT examinations on a digital PET/CT (Siemens Biograph Vision) with a total scan time duration of 15 minutes (reference acquisition protocol) and 5 minutes (reduced acquisition protocol) using continuous-bed-motion. Both data sets were reconstructed using either standalone time of flight (TOF) or in combination with point spread function (PSF), each with 2 and 4 iterations. Lesion detectability by blinded assessment (separately for supra- and infradiaphragmal nodal lesions and for extranodal lesions), lesion image quantification, and image noise were used as metrics to assess diagnostic performance. Additionally, Deauville Score was compared for all patients after systemic treatment.Results: All defined regions were correctly classified in the images acquired with reduced emission time, and therefore, no changes in staging were observed. Lesion quantification was acceptable, that is, mean absolute percentage deviation of maximum and peak standardized uptake values were 6.8% and 6.4% (derived from 30 lesions). A threefold reduction of scan time duration led to an increase in image noise from 7.1% to 11.0% (images reconstructed with 4 iterations) and from 4.7% to 7.2% (images reconstructed with 2 iterations). No deviations in Deauville Score were observed.Conclusion: These results suggest that scan time duration or administered tracer activity can be reduced threefold without compromising diagnostic performance. Especially a reduction of administered activity might allow for a lower radiation exposure and better health economics. Larger trials are warranted to confirm our results.
Comparative Transcriptome Analysis Provides Insights into The Response of Ulva Compressa to The Fluctuating Salinity Conditions
Authors: Xing Qikun , Bi Guiqi , Cao Min , Belcour Arnaud , Aite Méziane , Mao Yunxiang 
Published: August 2020

Abstract
Background: Ulva compressa, known as the green tide forming species, was reported that can adapt to hypo-salinity conditions such as estuaries and brackish lakes. To understand the underlying molecular mechanisms of hypo-salinity stress tolerance, a genome-wide gene expression profiles in U. compressa was performed using digital gene expression profile (DGE). Results: The RNA-seq data were analyzed based on the comparison of differently expressed genes involved in specific pathways under hypo-salinity and recovery conditions. Under the long-term hypo-salinity stress, the recovery of photosynthesis and energy metabolism could provide sufficient energy for the tolerance under long-term hypo-saline stress. Multiple strategies were performed to maintain the osmotic homeostasis. Additionally, several long non-coding RNA were detected as differently expressed genes during the stress, which could play important roles in the osmotolerance. Conclusions: Our work will serve as an essential foundation for the understanding of the tolerance mechanism of U. compressa under the fluctuating salinity conditions.
Does Chemotherapy or Radiotherapy Affect for Postoperative Complication in Patients Who Underwent Immediate Breast Reconstruction With Tissue Expander?
Authors: Jung Sung Mi , Jeon Byung-Joon , Woo Jinsun , Ryu Jai Min , Lee Se Kyung , Chae Byung-Joo , Yu Jonghan , Kim Seok Won , Nam Seok Jin , Bang Sa Ik , Mun Goo-Hyun , Pyon Jai-Kyong , Lee Jeong Eon 
Published: August 2020

Abstract
Background: Immediate breast reconstruction with tissue expander in patients who were expected to receive adjuvant therapy, such as chemotherapy or radiotherapy, has been a topic of debate. Postoperative complications from tissue expander procedures can delay the timing of adjuvant treatment and subsequently increase the probability of recurrence. The purpose of this study was to identify the impact of chemotherapy and radiotherapy on postoperative complications in patients who underwent immediate reconstruction (IR) using tissue expander.Method: We conducted a retrospective study of 1,081 breast cancer patients who underwent mastectomy and IR using tissue expander insertion between 2012 and 2017 in Samsung Medical Center. The patients were divided into two groups based on complications (complication group vs. no complication group). The complication group had 59 patients (5.5%) and the no complication group had 1,022 patients (94.5%). Results: In univariate analysis, lymphovascular invasion (LVI), pathologic N stage, pathologic prognostic stage, axillary lymph node dissection (ALND), adjuvant radiotherapy, and adjuvant chemotherapy were significantly associated with postoperative complications. In multivariate analysis, however, higher pathologic N stage was significantly associated with postoperative complications. Chemotherapy or radiotherapy were not risk factors for postoperative complications.Conclusions: IR with tissue expander after mastectomy may be a treatment option even when the patients are expected to receive adjuvant chemotherapy or radiotherapy. These results will aid preoperative counseling to patients who are concerned about the complications of IR caused by chemotherapy or radiotherapy.
Transcriptome Analysis of Genes and Pathways Associated With Metabolism in Scylla Paramamosain Under Different Light Intensities During Indoor Overwintering
Authors: Li Na , Zhou Junming , Wang Huan , Mu Changkao , Shi Ce , Liu Lei , Wang Chunlin 
Published: August 2020

Abstract
Background: Scylla paramamosain is one of the commercially crucial marine crustaceans belonging to the genus Scylla, which is commonly distributed along the coasts of China, Vietnam, and Japan. Genomic and transcriptomic data are scarce for the mud crab. Light intensity is one of the ecological factors that affect S. paramamosain during indoor overwintering. Methods: To understand the energy metabolism mechanism adapted to light intensity, we analyzed the transcriptome of S. paramamosain hepatopancreas in response to different light intensities (0, 1.43, 40.31 μmol·m-2·s-1). Results: A total of 5052 differentially expressed genes were identified in the LL group (3104 genes were up-regulated and 1948 genes were down-regulated). A total of 7403 differentially expressed genes were identified in the HL group (5262 genes were up-regulated and 2141 genes were down-regulated). Conclusion: The results showed that S. paramamosain adapts to different light intensity environments through the regulation of amino acids, fatty acids, carbon and energy metabolism. Different light intensities had a strong impact on the energy generation of S. paramamosain by influencing oxygen consumption rate, aerobic respiration, glycolysis/gluconeogenesis pathway, the citrate cycle (TCA cycle) and fatty acid degradation. The results of the current study showed that S. paramamosain produced more energy under high light intensities. The findings of the study add to the knowledge of regulatory mechanisms related to S. paramamosain metabolism under different light intensities.
DArT-seq based SNP analysis of diversity, population structure and linkage disequilibrium among 274 cowpea (Vigna unguiculata L. Walp.) accessions
Authors: Sodedji Frejus Ariel Kpedetin , Agbahoungba Symphorien , Agoyi Eric Echikintho , Kafoutchoni Konoutan Médard , Kim Ho-Youn , Nguetta Simon-Pierre Assanvo , Assogbadjo Achille Ephrem 
Published: August 2020

Abstract
Background: Genetic diversity in a germplasm is crucial for continuous improvement of crop varieties. A panel of 274 cowpea (Vigna unguiculata L.) accessions of unknown genetic diversity was assembled from diverse sources. This study used 3127 SNP markers, generated with the diversity array technology (DArT), to assess genetic diversity, population structure and linkage disequilibrium (LD) in the assembled germplasm.Results: The structure analysis inferred three subpopulations within the germplasm, which was confirmed by Neighbour-Joining (NJ) clustering and principal component analysis (PCA). Low genetic distances (0.005 to 0.44) were observed between accessions. Accessions from Africa; West and Central Africa (113 accessions), East and Central Africa (93 accessions), and Asia (53 accessions) were predominant in the germplasm; and distributed across all subpopulations. High fixation indexes (0.48 ≤ FST≤0.56) were obtained for the inferred subpopulations. AMOVA revealed a very large contribution (99%) of within subpopulations variation to the observed genetic variation in the germplasm. However, the expected heterozygosity (He) was higher than the observed heterozygosity (Ho), indicating high proportion of inbred lines in the germplasm. Linkage Disequilibrium (LD) was observed in the germplasm, particularly on chromosome 6, which showed a low decay along the physical genetic distance between markers in the genome.Conclusions: Significant genetic structuration exists in the assembled cowpea germplasm which shows there is a potential for improvement of the crop. The subgroups consisted mainly of inbred lines which, although from different geographical regions shared alleles in common reflecting high movement of seeds and exchange of germplasm between regions. The presence of linkage disequilibrium in the germplasm paves a way for prospective whole genome-wide association studies in cowpea for quality attributes and important agronomic traits.
The Predictive Value of MAP and ETCO2 Changes After Emergency Endotracheal Intubation for Severe Cardiovascular Collapse
Authors: Jiayuan Dai , Lu Yin , Xiao Song , Yangyang Fu , Ming Gu , Huadong Zhu , Xu Jun , Xuezhong Yu 
Published: August 2020

Abstract
Objective: To analyze the changes in mean arterial pressure (MAP) and end-tidal CO2 (ETCO2) in patients after emergency endotracheal intubation (ETI). To explore the values of MAP and ETCO2 monitoring in the early prediction of severe cardiovascular collapse (CVC). Methods: The clinical data of patients who underwent ETI were collected. The values of both MAP and ETCO2 were observed and recorded at 5 minutes, 10 minutes, 30 minutes, 60 minutes and 120 minutes post intubation. According to whether severe CVC occurred after ETI, the patients were divided into a severe CVC group and a non-severe CVC group. The values of MAP and ETCO2 were compared at the same time points. The correlation between MAP and ETCO2 after ETI was also analyzed. receiver operating characteristic curves(ROC curves) were used to analyze the ability of MAP and ETCO2 at 5 minutes and 10 minutes after ETI to predict severe CVC.Results: A total of 116 patients were enrolled in this study; among them, 75 (64.7%) had severe CVC after ETI. The majority of subjects in the severe CVC group were male and elderly patients. The values of MAP and ETCO2 at 5 minutes, 10 minutes, 30 minutes, 60 minutes and 120 minutes after ETI in the severe CVC group were significantly lower than those in the non-severe group. Both MAP and ETCO2 in the two groups showed simultaneous decreases from 5 minutes to 30 minutes after ETI, reaching their lowest values at 30 minutes after ETI. After ETI, the changes in MAP were correlated with those in ETCO2 (rs = 0.653, P < 0.001). At 5 minutes after ETI, MAP could predict severe CVC (AUC = 0.86, P < 0.001), MAP≤72 mmHg was the best cutoff value (sensitivity 78.7%, specificity 87.8%), and ETCO2 could also predict severe CVC (AUC = 0.85, P < 0.001). ETCO2≤35 mmHg was the best cutoff value for predicting severe CVC (sensitivity 77.3%, specificity 85.4%). At 10 minutes after ETI, MAP could predict severe CVC (AUC = 0.90, P < 0.001), MAP≤67 mmHg was the best cutoff value (sensitivity 89.3%, specificity 85.4%), and ETCO2 could also predict severe CVC (AUC = 0.87, P < 0.001). ETCO2≤33 mmHg was the best cutoff value for predicting severe CVC (sensitivity 81.3%, specificity 78%). There was no significant difference in the predictive ability between any two cutoff values of MAP or ETCO2 at 5 minutes and 10 minutes after ETI (P >0.05). Conclusion: Both MAP and ETCO2 values of the patients with severe CVC were significantly lower than those of patients without severe CVC from 5 minutes to 120 minutes after ETI, reaching their lowest values at 30 minutes after ETI. MAP and ETCO2 values changed synchronously with the time after intubation. There was a positive correlation between MAP and ETCO2 after ETI. MAP and ETCO2 values in the early stage after ETI have high accuracy in predicting severe CVC.
Transcriptome Profiling of Developing Leaf and Shoot Apices to Reveal the Molecular Mechanism and Coexpression Genes Responsible for the Wheat Heading Date
Authors: Yang Yuxin , Zhang Xueying , Zhang Lichao , Liu Guoxiang , Xia Chuan , Liu Xu , Kong Xiuying 
Published: August 2020

Abstract
Background: Wheat is one of the most widely planted crops worldwide. The heading date is important for wheat environmental adaptability; it not only controls flowering time but also determines the yield component in terms of the grain number per spike. Results: In this research, homozygous genotypes with early and late heading dates derived from backcrossed progeny were selected to conduct RNA-seq analysis at the double ridge stage and androgynous primordium differentiation stage of the leaf and apical meristem, respectively. In total, 18,352 differentially expressed genes (DEGs) were identified. Five common GO terms and 214 common metabolic pathways were obtained by MapMan software. In addition, 1,225 DEGs were annotated to 52 transcription factor gene families, and we discovered that most of the LFY, SBP, and MADS-box genes were highly expressed during the apical development of wheat with the early heading date. Additionally, weighted gene coexpression network analysis (WGCNA) found that the DEGs clustered into 17 coexpression modules, and 16, 336, 446, and 124 DEGs had biological connections with Vrn1-5A, Vrn3-7B, Ppd-1D, and WSOC1, respectively. The 16 genes connected with Vrn1-5A were divided into three types of expression patterns. We further identified one important flowering time gene, TraesCS2D02G181400, which is a MADS-MIKC transcriptional factor and has a biological connection with Vrn1-5A. Gene function showed that this gene was differentially expressed at the A2.0 and L3.5 stages between the genotypes with early and late heading.Conclusions: The RNA-seq analysis results in our present research are a valuable bioinformatics resource for further study of the molecular mechanism of the wheat heading date. Overall, our results shed light on the genetic architecture of wheat flowering time.
Relationship between sociocultural attitudes toward appearance and depression among patients with obesity
Authors: Czeglédi Edit 
Published: August 2020

Abstract
Background: Obesity is a significant risk factor for mental health. Depression and obesity appear to have a bi-directional relationship in which a number of mediating factors may play a role, such as body dissatisfaction. Unrealistic messages related to image may contribute to depression in individuals with excess weight through body image dissatisfaction. The aim of the present study was to investigate the role of appearance-related sociocultural attitudes in the development of two common comorbid psychological characteristics of obesity, namely, body image dissatisfaction and depression. Methods: The sample of the cross-sectional survey consisted of participants in an inpatient weight loss treatment (n = 339, 19% men). The mean age was 50.2 (SD = 13.47) years, the mean BMI was 38.6 (SD = 7.58) kg/m2. Measures: self-reported anthropometric data, Sociocultural Attitudes Towards Appearance Questionnaire-3, Body Shape Questionnaire – Short form 14, CES-D Depression Scale. Results: Results of path analysis revealed many weak but significant indirect paths between appearance-related sociocultural attitudes and depression through body image dissatisfaction (χ2 = 688.23, df = 35, p < .001; CFI = .995; TLI = .973; RMSEA = .039, 90% CI: .00 – .08; SRMR = .013). The model explains 31.8% of the variance of body dissatisfaction and 23.3% of the variance of depressive symptoms. Conclusions: Assessing the extent and causes of body image dissatisfaction and depression, and striving to reduce them can be a valuable addition of weight loss programs.
Risk Factors for Brain Metastases in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis of 43 Studies
Authors: Chen Shanshan , Hua Xin , Jia Jinfang , Wu Ying , Wei Shuzhen , Xu Lu , Han Shuhua , Zhang Hongming , Zhu Xiaoli 
Published: August 2020

Abstract
Background: Lung cancer is a leading cause of cancer-related mortality worldwide. The purpose of our meta-analysis was to assess the risk factors for brain metastases in patients with non-small cell lung cancer.Methods: Multiple databases, including PubMed, EMBASE, Cochrane Library, CNKI and Wanfang were systematically searched, then the meta-analysis was performed with RevMan 5.3 software and carried out evidence quality evaluation according to the GRADE standard. The estimated odds ratio and 95% confidence intervals were set as effect measures. Moreover, funnel plots and sensitivity analysis were used to assess the publication bias and reliability of the articles, respectively. Results: A total of 43 studies with 11415 participants were eligible. The results indicated that female, adenocarcinoma or non-squamous cell carcinoma, advanced tumor stage, node stage, 1ymphatic metastasis, epidermal growth factor receptor gene mutation, kirsten rat sarcoma viral oncogene gene mutation, and higher levels of carcinoembryonic antigen, carbohydrate antigen 199, cytokeratin-19 fragment, neuron-specific enolase and carbohydrate antigen 125 were significantly associated with an increased risk of brain metastases (P<0.05) in non-small cell lung cancer patients. Moreover, the non-small cell lung cancer with brain metastases group had a significantly lower survival rate than the non-small cell lung cancer group (P<0.05).Conclusions: The meta-analysis demonstrated that non-small cell lung cancer patients with brain metastases have more aggressive clinical features and poor survival prognosis.