bluuebunny/crossref_metadata_2025_split huggingface dataset:
“My Research Is Their Business, but I'm Not Their Business”: Patient and Clinician Perspectives on Commercialization of Precision Oncology Data
Authors: Spector-Bagdady Kayte , Krenz Chris D. , Brummel Collin , Brenner J. Chad , Bradford Carol R. , Shuman Andrew G. 
Published: March 2020

AbstractBackgroundGenetic sequencing and precision oncology have supported clinical breakthroughs but depend upon access to vast arrays of research specimens and data. One way for academic medical centers to fund such infrastructure and research is “commercialization” of access to specimens and data to industry. Here we explore patient and clinician perspectives regarding cancer specimen and data commercialization with the goal of improving such processes in the future.Materials and MethodsThis qualitative analysis was embedded within a prospective precision oncology sequencing study of adults with head and neck cancer. Via semistructured dyadic interviews with patients with cancer and their doctors, we assessed understanding and concerns regarding potential commercialization, opinions regarding investment of profits, and perspectives regarding the return of information directly to participants from industry.ResultsSeveral patient- and clinician-participants did not understand that the consent form already permitted commercialization of patient genetic data and expressed concerns regarding who would profit from the data, how profits would be used, and privacy and access. Patients were generally more comfortable with commercialization than clinicians. Many patients and clinicians were comfortable with investing profits back into research, but clinicians were more interested in investment in head and neck cancer research specifically. Patients generally supported potential return-of-results from a private entity, but their clinicians were more skeptical.ConclusionOur results illustrate the limitations of mandatory disclosures in the informed consent process. The voices of both patients and their doctors are critical to mitigate violations of privacy and a degradation of trust as stakeholders negotiate the terms of academic and commercial engagement.Implications for PracticeFurther education is needed regarding how and why specimens and data in precision oncology research may be commercialized for both patients and providers alike. This process will require increased transparency, comprehension, and engagement of involved stakeholders.
Cu(II) İyonlarının Sulu Çözeltilerden Poli(Vinil Pirilidon)-Poli(Vinil Alkol)/Selüloz Membranlarla Ayrılması
Authors: ÇİFCİ Cemal , MAVİLİ Funda 
Published: March 2020

Bu çalışmada
Cu(II) iyonlarının sulu ortamdan uzaklaştırılması kesikli karıştırıcılı
ultrafiltrasyon hücresi ile yapılmıştır. Bu çalışmada poli(vinil
pirilidon)-poli(vinil alkol)/Selüloz membranları
kullanılmıştır. Aljinik asit polimerleri tutulmayı arttırma amacıyla kompleks
ajan olarak kullanılmıştır. Cu(II)’nin sulu çözeltileri değişik pH, basınç ve
çözelti derişimleri ile filtre edilmiştir. Cu(II) için en uygun tutulma
değeri % 2 (m/v) poli(vinil
pirilidon)- %
2 (m/v) poli(vinil
alkol)/Selüloz membranları
kullanılarak AA varlığında pH 6’ da, 30 psi basınçta, 0,5x10-4 M Cu(II)
konsantrasyonda ve
400 devir/dakika karıştırma hızında 82,9 %
olarak bulunmuştur.
7-Etil-6-klor-2-metilkromon ve 7-Etil-6-klorflavonun Sentezi ve Teorik Hesaplamaları
Authors: KARABULUT Bayhan 
Published: March 2020

Bu
çalışmada, 7-Etil-6-klor-2-metil kroman ve 7-Etil-6-klorflavon bileşikleri
sentezlenip, teorik spektroskopik özellikleri B3LYP/6-31G (d,p) temel seti ile
araştırılmıştır. Sentezlenen bileşiklerin ilk olarak DFT yöntemi ve 6-31G (d,p)
temel setinden faydalanılarak optimizasyonları yapılmıştır. H-NMR, kimyasal
kayma değerleri hesaplanmış, teorik olarak hesaplanan değerlerin elde edilen
deneysel verilerle uyum içinde oldukları görülmüştür. Deneysel ve teorik
kimyasal kayma değerleri için korelasyon grafiği ile regrasyon analizleri
yapılmıştır. Bunlara ilaveten çalışılan bileşiklerin en yüksek dolu moleküler
orbital enerjisi (HOMO) ve en düşük boş moleküler orbital enerjisi (LUMO), bağ
uzunlukları, bağ açıları ve mulliken atomik yük değerleri hesaplanmıştır. HOMO
ve LUMO enerji değerlerinden yararlanılarak iyonizasyon potansiyeli elektron
ilgisi, elektronegatiflik, kimyasal
sertlik, kimyasal yumuşaklık gibi parametrelerin hesaplamaları bir tablo
halinde sunulmuştur.
THE QUALITY OF LIFE AND SOCIAL ANXIETY LEVELS OF CHILDREN WITH PANCREATITIS
Authors: Balat Volkan , Bükülmez Ayşegül , Tolunay Oflu Ayşe 
Published: March 2020

Acute
pancreatitis (AP) and acute recurrent pancreatitis (ARP) are the diseases that
affect the quality of life and level of anxiety in children. In the literature,
studies that measure the life quality or anxiety levels of children with pancreatitis
are very limited. The aim of this study was to compare pancreatitis cases with
a healthy control group in terms of life quality and anxiety levels. A total of 40 patients with pancreatitis and
40 healthy volunteers were included in this study. Age, gender, quality of life
scale and social anxiety scores of the study group were recorded. In comparison
of mean and median values of the groups, independent t-test, ANOVA, Mann
Withney U and Kruskal-Wallis tests were used according to the normal
distribution suitability. Pancreatitis and control groups were similar
in terms of age and sex (p&gt; 0.05). Comparing the scores of social anxiety
scale, average score of control group was lower than the other two groups (p
&lt;0.001). When the scores obtained from the quality of life scale were
compared, physical health (p &lt;0.001), psychosocial health (p &lt;0.001) and
average score (p &lt;0.001) of control group were lower than the other two
groups. There was no significant difference between the scores of children with
AP and ARP. Children with pancreatitis had
lower quality of life and higher social anxiety scores. It is necessary to
increase the awareness of clinicians on this issue and to carry out further
studies in larger study groups.
STOCK SPLIT AND STOCK MARKET REACTION: THE EVIDENCE OF INDONESIAN PUBLIC COMPANY
Authors: Trisanti Theresia 
Published: March 2020

Purpose of study: Go Public Company can raise funds for its operations through the sale of shares to investors. But if the stock price is too high, it can make the investors are not interested in buying stock. Stock market value can be reduced by the stock-split. This study aims to examine the effect of the stock split on abnormal return, stock price; trading volume and security return variability in the go public company on the Indonesia Stock Exchange.
Methodology: Researchers use data from 41 companies that were taken by purposive sampling from 2013 to 2016. The hypotheses in this study were tested using a Paired sample t-test.
Result: The researcher found that the stock split event causes the difference between the stock price, trading volume and security return variability between before and after the stock split. But the results found that the stock split did not cause any differences between the abnormal return before and after the stock split.
Application: The results of this study can provide an overview of the relationship between stock split events with stock prices and stock trading volumes.
Novelty/Originality of this study: This research using different methods compare with previous, namely multiple discriminant analysis. The multiple discriminant analysis methods are part of the discriminant analysis, which is a multivariate technique that includes the dependence method, namely the presence of variables.
SOCIO-EDUCATIONAL IDEA OF EDUCATORS AND EDUCATORS OF THE SECOND HALF OF THE XIX - EARLY OF THE XX CENTURY
Authors: Matros Olha , Pidvalna Iuliia , Morgay Lilia 
Published: March 2020

Purpose of the study: This study aims to find out the changes in the historical and pedagogical process of the late 19th – early 20th centuries and to identify the influence of prominent pedagogues and scholars Oleksiy Andrievsky, Ivan Luchytsky and Nyky for Hryhoriv on the socio-educational process of that time.
Methodology: To achieve the goal of the study authors implied theoretical method to provide scientific literary sources analysis, general-scientific method, for instance, analysis, synthesis, comparison of received information and scientific-historical method making chronological and logic-historical analysis.
Main Findings: It was revealed that studied authors stated valuable pedagogical ideas on various problems of a pedagogical science and has become an important factor in the educational revival in the difficult conditions of the socio-educational and cultural life of Ukraine in the second half of the 19th – early 20th century.
Applications of this study: This study provides information that is of particular interest for teachers of Ukrainian literature, researchers and historians, due to political processes for a long time these persons remained taboo for domestic researchers. It was revealed the socio-education tendencies of the late 19th – early 20th centuries and thoroughly examined the work of prominent pedagogues of that time it will start new researches and run new results.
Novelty/Originality of this study: Scientific heritage of Oleksiy Andrievsky, Ivan Luchytsky and NykyforHryhoriv due to political processes for a long time remained taboo for domestic researchers. Therefore, the analysis and understanding of educators’ views on socio-educational ideas are particularly important.
GRATITUDE BEHAVIOR IN LIVING OF INDONESIAN ORPHAN ADOLESCENTS BASED ON ISLAMIC PERSPECTIVE
Authors: Samsul Arifin Bambang , Salamah Ummu 
Published: March 2020

Purpose of the study: This study aims to see how orphaned adolescent’s gratitude who grew up in the environment without biological parents which psychologically certainly have different emotions from other normal adolescents. The orphan adolescent’s gratitude is analyzed based on the Islamic perspective in Indonesia as a majority Muslim population country because religion becomes an important foundation for humans to live their lives.
Methodology: This study used a qualitative method with observation, interviews, and documentation with 15 orphan adolescents in Sukabumi district, Indonesia. Data analysis was carried out to find the meaning of the data or information obtained in a systematically arranged research, among others: Initial data analysis, make a description, make a final, and making conclusions.
Main Findings: The results showed that the orphaned adolescent's gratitude was able to give thanks to both personal and transpersonal. They acknowledge, accept, and utilize gifts from others and the gift of God. They also always do good to others, worship, and do good deeds because of God. So, rise and maximize their potential as a gift of God and avoid the negative behavioral tendencies that accompany their shortcomings.
Applications of this study: This study can be useful for the social science research area, specifically in psychology studies. In addition, the results of this study are very useful for the orphan adolescents themselves for the importance of motivating themselves, staying confident, and having a strong sense of gratitude, which is also a concern for the Indonesian government.
Novelty/Originality of this study: This study found that several factors that influence gratitude, namely: contemplation with emotional intelligence, input, and advice from family, neighbours, and friends; constructive criticism and judgment of others. This gratitude emerged as a reflection of gratitude understanding from an Islamic perspective. Moreover, this study created a model of orphan adolescent's gratitude based on Islamic perspective.
EXPLORATION OF E-LEARNING VS TRADITIONAL LEARNING IN INDIA
Authors: Singh Gulbir , Bhatnagar Vivek , Gupta Rajeev , Kumar Gautam 
Published: March 2020

Purpose of Study: The purpose of the study is to carry out the comparison of traditional learning and e-learning with reference to university education.
Methodology: A comparative analysis method that has been selected to fulfill the purpose of the study. The research data has been collected by various sources internet, previous research studies published in the Journal, universities which offer different technical and nontechnical programs .and further analyzed by in-depth understanding approach.
Result: The outcome of this study will show the effect of e-learning in the current era. As we have compared e-learning with traditional learning and the result shows us that e-learning has filled the gap between the universities and the real-life industries' demands.
Main finding: The result of this study showed that e-learning is the need of the present era in order to fulfill the gap between the universities and the real-life industries' demands. Additionally, e-learning based courses will have more impact and provide more skill and exposure to students as compared to traditional learning mode.
Implications/Applications: This article can help the different universities and students to introduce more e-learning courses in their curriculum and they can fill the real-time industries' demands.
Novelty/originality of the study: Our research can ensure that e-learning has a huge impact on our students and can help to increase the skills and exposure of them according to the current demands.
Caracterización de la mineralización del proceso estilohioideo en tomografías computarizadas volumétricas
Authors: Benito Sifuentes Roger , Miroslava Quezada Milushka , Evangelista Alexis 
Published: March 2020

Objetivo: Analizar las características tomográﬁcas de la mineralización del proceso estilohioideo (MPE) me- diante tomografía computarizada volumétrica (TCV). Material y Métodos: Se revisaron 860 tomografías computarizadas volumétricas (593 corresponden al sexo femenino y 267 al sexo masculino) de un servicio de Radiología Bucal y Maxilofacial. El rango etario estuvo comprendido entre 6 a 89 años. Se utilizó la adecua- ción tomográﬁca de la clasiﬁcación de Langlais. El análisis estadístico se realizó mediante el uso de la prueba chi-cuadrado. Resultados: Se encontraron 289 MPE, prevaleció la mineralización bilateral (68.86%). La longi- tud promedio aritmética de las MPE fue de 39.54 mm. La frecuencia de la MPE fue del 33.60% (289 casos). Se encontró mayor frecuencia en el grupo etario de 40 a 49 años, no hubo diferencia signiﬁcativa entre el sexo femenino y masculino (p=0.53). En la clasiﬁcación de Langlais el tipo más frecuente fue la variante segmentado con 42.2%. El patrón de MPE más frecuente fue la variantes parcialmente calciﬁcada con 58.8%. Conclusiones: La frecuencia de la MPE fue de 33.60% y la TCV permite identiﬁcar oportunamente esta variación anatómica.
Challenges and barriers of Humanitarian Aid Management in 2017 Kermanshah Earthquake: A Qualitative Content Analysis
Authors: Safarpour Hamid , Fooladlou Saeideh , Safi-Keykaleh Meysam , Mousavipour Somayyeh , Pirani Davoud , Sahebi Ali , Ghodsi Hassan , Ashtiani Iman Farahi , Dehghani Arezoo 
Published: March 2020

Abstract
Background

Examining various problems after disasters is important for the affected people. Managing humanitarian aid and donations among the affected people is considered as one of the most important problems after disasters. Therefore, the present study aimed to evaluate the challenges and barriers of humanitarian aid management in 2017 Kermanshah Earthquake.

Methods

In the present study conducted from November 2017 to January 2018, conventional qualitative content analysis method was used. The population included 21 people including 6 humanitarian aid manager, 6 volunteers, 4 aid workers, and 5 affected people. The data were collected through semi-structured interviews and purposeful sampling, which continued until saturating the data. The strategies recommended by Guba were used for evaluating the trustworthiness of the data. The data was analyzed according to method suggested by Graneheim and Lundman.

Results

Based on the results, two themes, nine categories, and 19 sub-categories were identified considering the challenges and barriers of humanitarian aid and donors’ management during the 2017 Kermanshah Earthquake. The categories included education, command and coordination, communication and information, rules, security, traffic and overcrowding, assessment, providing system, and cultural setting. Also, two themes including managerial and structural barriers were extracted.

Conclusion

Adopting an effective management and appropriate policies with respect to humanitarian aid and modifying structural and managerial barriers can improve the performance and management of humanitarian aid.
Changes in perceived knowledge about childbirth among pregnant women participating in the Senses of Birth Intervention in Brazil: A cross-sectional study
Authors: Fernandes Luísa M M , Lansky Sônia , Oliveira Bernardo J , Friche Amélia A L , Bozlak Christine T. , Shaw Benjamin A. 
Published: March 2020

Abstract
Background: Senses of Birth (SoB) is a health education intervention in Brazil that addresses reproductive rights, the benefits and risks of normal birth and cesarean, and use of evidence-based practices (EBP) during labor and childbirth, aiming to reduce unnecessary cesareans in the country. This study evaluates the impact of the SoB intervention on pregnant women’s perceived knowledge about normal birth, cesarean, and use of EBP in childbirth. Method: 1,287 pregnant women answered a structured questionnaire, immediately after their visit to the exhibition, between March 2015 and March 2016, in four cities. To identify the impact of the intervention on women’s perceived knowledge and possible association with socioeconomic and demographic characteristics, statistical analyses were performed including paired T-tests, ANOVA, and logistic and linear regressions. Results: The mean score (MS) of perceived knowledge after the intervention was higher than the mean score before experiencing the SoB for all three knowledge domains: Normal Birth (MS Before= 3.71 x MS After= 4.49), Cesarean (MS Before= 3.54 x MS After= 4.26) and EBPs (MS Before= 3.14 x MS After= 4.14). The results suggest that SoB intervention was more effective for low income women (B = 0.206; p < 0.001 for EBP), women without private health insurance (OR 2.47, 95% CI: 1.49- 4.09 for normal birth), women with private prenatal care (OR 2.42, 95% CI: 1.59- 3.66 for normal birth), women experiencing their first pregnancy (OR 1.92, 95% CI: 1.31-2.82 for EBP; OR 1.37, 95% CI: 1.03-1.84 for normal birth; OR 1.37, 95% CI: 1.03-1.84 for cesarean), and women in their first or second trimester at the time of the intervention (OR 1.64, 95% CI: 1.13-2.39 for EBP; OR 1.48, 95% CI: 1.11-1.97 for normal birth; OR 1.85, 95% CI: 1.40-2.41 for cesarean). Conclusion: The study showed opportunities to increase knowledge among Brazilian pregnant women for the three knowledge domains, and a need to focus the discussion on how to achieve a positive experience of birth using EBP. The intervention gains relevance considering the lack of evidence of the efficacy of non-clinical interventions to reduce unnecessary cesareans in middle and low-income countries targeting women.
Improved ascertainment of modes of HIV transmission in Ukraine indicates importance of drug injecting and homosexual risk
Authors: Dumchev Kostyantyn , Kornilova Marina , Kulchynska Roksolana , Azarskova Marianna , Vitek Charles 
Published: March 2020

Abstract
Background

It is important to understand how HIV infection is transmitted in the population in order to guide prevention activities and properly allocate limited resources. In Ukraine and other countries where injecting drug use and homosexuality are stigmatized, the information about mode of transmission in case registration systems is often biased.

Methods

We conducted a cross-sectional survey in a random sample of patients registered at HIV clinics in seven regions of Ukraine in 2013-2015. The survey assessed behavioral risk factors and serological markers of viral hepatitis B and C. We analyzed the discrepancies between the registered mode of transmission and the survey data, and evaluated trends over three years.

Results

Of 2,285 participants, 1,032 (45.2%) were females. The proportion of new HIV cases likely caused by injecting drug use based on the survey data was 59.7% compared to 33.2% in official reporting, and proportion of cases likely acquired through homosexual transmission was 3.8% compared to 2.8%. We found a significant decrease from 63.2% to 57.5% in the proportion of injecting drug use-related cases and a steep increase from 2.5 to 5.2% in homosexual transmission over three years.

Conclusions

The study confirmed the significant degree of misclassification of HIV mode of transmission among registered cases. The role of injecting drug use in HIV transmission is gradually decreasing, but remains high. The proportion of cases related to homosexual transmission is relatively modest, but is rapidly increasing, especially in younger men. Improvements in ascertaining the risk factor information are essential to monitor the epidemic and to guide programmatic response.
Validation of RESP and PRESERVE score for ARDS patients with pumpless Extracorporeal Lung Assist (pECLA)
Authors: Petran Jan , Muelly Thorsten , Dembinski Rolf , Steuer Niklas , Arens Jutta , Marx Gernot , Kopp Ruedger 
Published: March 2020

Abstract
Background RESP score and PRESERVE score have been validated for veno-venous Extracorporeal Membrane Oxygenation in severe ARDS to assume individual mortality risk. ARDS patients with low-flow Extracorporeal Carbon Dioxide Removal, especially pumpless Extracorporeal Lung Assist, have also a high mortality rate, but there are no validated specific or general outcome scores. This retrospective study tested whether these established specific risk scores can be validated for pumpless Extracorporeal Lung Assist in ARDS patients in comparison to a general organ dysfunction score, the SOFA score. Methods In a retrospective single center cohort study we calculated and evaluated RESP, PRESERVE, and SOFA score for 73 ARDS patients with pumpless Extracorporeal Lung Assist treated between 2002 and 2016 using the XENIOS iLA Membrane Ventilator. 6 patients had a mild, 40 a moderate and 27 a severe ARDS according to the Berlin criteria. Demographic data and hospital mortality as well as ventilator settings, hemodynamic parameters, and blood gas measurement before and during extracorporeal therapy were recorded. Results Pumpless Extracorporeal Lung Assist of mechanical ventilated ARDS patients resulted in an optimized lung protective ventilation, significant reduction of PaCO2, and compensation of acidosis. Scoring showed a mean score of alive versus deceased patients of 3 ± 1 versus -1 ± 1 for RESP (p < 0.01), 3 ± 0 versus 6 ± 0 for PRESERVE (p < 0.05) and 8 ± 1 versus 10 ± 1 for SOFA (p < 0.05). Using receiver operating characteristic curves, area under the curve (AUC) was 0.78 (95 % confidence interval (CI) 0.67 – 0.89, p < 0.01) for RESP score, 0.80 (95 % CI 0.70 – 0.90, p < 0.0001) for PRESERVE score and 0.66 (95 % CI 0.53 – 0.79, p < 0.05) for SOFA score. Conclusions RESP and PRESERVE scores were superior to SOFA, as non-specific critical care score. Although scores were developed for veno-venous ECMO, we could validate RESP and PRESERVE score for pumpless Extracorporeal Lung Assist. In conclusion, RESP and PRESERVE score are suitable to estimate mortality risk of ARDS patients with an arterio-venous pumpless Extracorporeal Carbon Dioxide Removal.