bluuebunny/crossref_metadata_2025_split huggingface dataset:
Een nieuwe Regeling beoordelingscommissie late zwangerschapsafbreking en levensbeëindiging bij pasgeborenen
Authors: Dorscheidt J.H.H.M. 
Published: October 2019

Een nieuwe Regeling beoordelingscommissie late zwangerschapsafbreking en levensbeëindiging bij pasgeborenen: goede inval of bedenkelijke manoeuvre?
In deze bijdrage wordt de nieuwe Regeling inzake late zwangerschapsafbreking (LZA) en levensbeëindiging bij pasgeborenen (LP) besproken en becommentarieerd. Daarbij wordt vooral nagegaan in hoeverre deze nieuwe Regeling eerder gesignaleerde knelpunten in de LZA/LP-praktijk daadwerkelijk kan verhelpen en hoe de keuze om de nieuwe beoordelingscommissie overwegend medisch in te kleuren past bij het te waarborgen belang van maatschappelijke zorgvuldigheid.
Het gebruik van patiëntgegevens in de nieuwe klachtenprocedure
Authors: Philips-Santman C.E. 
Published: October 2019

Het gebruik van patiëntgegevens in de nieuwe klachtenprocedure
De heersende opvatting dat voor het gebruik van patiëntgegevens in een klachtenprocedure uitdrukkelijke toestemming van een patiënt nodig is, moet in het kader van de inwerkingtreding van de Wkkgz worden heroverwogen. Twee belangrijke wijzigingen in het klachtrecht geven daarvoor aanleiding: (1) een zorgaanbieder is voor de interne behandeling van een klacht niet langer verplicht gebruik te maken van een onafhankelijke klachtencommissie en (2) een zorgaanbieder is verplicht zich aan te sluiten bij een geschilleninstantie die (in tweede instantie) bij wege van bindend advies over een klacht oordeelt. Als een zorgaanbieder zelf een oordeel velt over de gegrondheid van een klacht moet het gebruik van patiëntgegevens in dat kader ook zonder toestemming van de patiënt mogelijk zijn. De procedure bij een geschilleninstantie valt onder de reikwijdte van artikel 6 lid 1 EVRM. De daarmee samenhangende waarborgen zouden ook van toepassing moeten zijn op de afhandeling van een klacht in ‘eerste aanleg’.
De verzwaarde betwistplicht: gebrekkige verslaglegging en een rechtsvergelijkend perspectief
Authors: Beekhof A. 
Published: October 2019

De verzwaarde betwistplicht: gebrekkige verslaglegging en een rechtsvergelijkend perspectief
Een belangrijke factor die eraan bijdraagt dat medische schade weinig verhaald wordt, is dat de bewijslast bij de patiënt ligt, terwijl het bewijsmateriaal zich veelal bij de hulpverlener bevindt. In de Nederlandse rechtspraak is voor dit probleem een oplossing gevonden in de zogenoemde ‘verzwaarde stelplicht’ of ‘verzwaarde betwistplicht’. Een belangrijke vraag is wat in het kader van deze plicht rechtens is wanneer de medische verslaglegging gebrekkig is. De antwoorden op deze vraag geven aanleiding tot rechtsvergelijking: de bewijsrechtelijke positie van de patiënt heeft bij onze oosterburen in bepaalde situaties een meer afgewogen regeling gekregen.
Kroniek rechtspraak Wet Bopz
Authors: Dörenberg V.E.T. 
Published: October 2019

Kroniek rechtspraak Wet Bopz
Deze kroniek bevat een selectie van rechtspraak die is gewezen in de periode van 1 februari 2015 tot 1 september 2016. Er is aandacht voor uitspraken met betrekking tot de inhoudelijke vereisten voor gedwongen opneming, de procedurele vereisten, vereisten rondom bijzondere machtigingen en vereisten rondom gedwongen verblijf. Daarbij wordt eveneens verwezen naar relevante tuchtrechtelijke uitspraken. Speciale aandacht is er voor samenloop met het strafrecht.
Kroniek rechtspraak rechten van de mens
Authors: Hendriks A.C. 
Published: October 2019

Kroniek rechtspraak rechten van de mens
Het Europees Hof voor de Rechten van de Mens (EHRM of Hof) heeft in de periode september 2015 tot en met 31 december 2016 een groot aantal uitspraken gedaan die voor gezondheidsjuristen van belang zijn. In het bijzonder zijn de uitspraken over de samenwerking tussen artsen en ziekenhuizen van belang, alsmede diverse uitspraken over onvrijwillige opnames, het ontnemen van de handelingsbekwaamheid van patiënten en het in het openbaar uiten van kritiek door en op artsen. Deze en andere zaken, die ook voor Nederland relevant zijn, worden in deze kroniek besproken.
Kroniek rechtspraak zorgverzekeringsrecht
Authors: van Balen C. , Michels C.M.E. 
Published: October 2019

Kroniek rechtspraak zorgverzekeringsrecht
Deze Kroniek rechtspraak zorgverzekeringsrecht bevat een selectie van gepubliceerde rechtspraak die betrekking heeft op de Zorgverzekeringwet (Zvw), de Algemene Wet Bijzondere Ziektekosten (AWBZ) en – voor het eerst – de Wet langdurige zorg (Wlz). Er zijn uitspraken geselecteerd uit de periode 1 januari 2015 tot 1 april 2017.
Formation de stagiaires en enseignement ayant une situation de handicap : points de vue des formateurs de terrain
Authors: Lebel Christine , Bélair Louise , Monfette Olivia , Hurtel Benoit , Miron Geneviève , Blanchette Sylvie 
Published: October 2019

Cette étude vise l’analyse des tensions, des défis et des besoins entourant la formation et l’accompagnement de stagiaires en situation de handicap (SH) par des formateurs de terrain selon deux axes. Le premier concerne leur regard sur le fait d’offrir des mesures d’accommodement en les adaptant aux stages et le second porte sur l’accompagnement, la formation et l’évaluation des stagiaires en SH.Il ressort d’un questionnaire en ligne et de groupes de discussion auprès de formateurs de terrain, pour le premier axe, qu’une forte proportion de répondants sont moins favorables à offrir des mesures d’accommodement, surtout dans les derniers stages, puisque l’autonomie du stagiaire en SH et son rendement au travail sont jugés prioritaires. En ce qui concerne le second axe, l’ouverture des répondants à former des stagiaires en SH dépend entre autres de la nature du handicap, des tensions que celui-ci occasionne dans la charge de travail et de leurs craintes relatives au manque d’ouverture de la société. Ils revendiquent de manière claire des formations sur cette problématique par des spécialistes de la question et des stratégies à mettre en place par les institutions pour assurer un meilleur suivi des stagiaires.
La conception du projet universel dans le renouveau de la pensée communiste : pistes théoriques sur les pratiques de la multitude
Authors: Casséus Joel , Moussaly Omer 
Published: October 2019

Quel sens peut bien avoir le pouvoir de la multitude au début du 21e siècle ? Nous pourrions conclure hâtivement avec Francis Fukuyama que nous avons atteint la fin de l’Histoire. Mais l’Histoire continue et d’autres penseurs refusent de croire que le projet d’émancipation universelle communiste est mort. Herbert Marcuse propose de revaloriser la pensée négative. Zizek, pour sa part, suggère l’établissement d’un nouvel universel. Dans cet article nous proposons le concept de « rupture hégémonique » afin de rendre opératoire l’analyse du passage d’une société civile pacifiée au renouveau de cette pensée négative.
État des lieux du jeu vidéo dans les bibliothèques françaises
Authors: Devriendt Julien 
Published: October 2019

Des bibliothèques de lecture publique à la Bibliothèque nationale de France, en passant par les bibliothèques universitaires et départementales, le jeu vidéo a réussi en une dizaine d’années à s’intégrer au sein des collections des établissements français. Comment le jeu vidéo a-t-il été progressivement légitimé en tant que forme de création à part entière ? Quels changements son arrivée a-t-elle induits au sein des bibliothèques ? Quel a été son impact sur les missions et le fonctionnement de nos établissements ? Comment en assurer la médiation ? Nous proposons ici de réaliser un état des lieux de l’introduction du jeu vidéo dans les bibliothèques françaises au cours des dix dernières années, à travers une synthèse des écrits professionnels disponibles.
A simplified correlation between vertebrate evolution and Paleozoic geomagnetism
Authors: Staub John P 
Published: October 2019

Background. Despite a fifty-year failure of paleontologists to find a viable connection between geomagnetic polarity reversals and evolutionary patterns, recent paleobiology databases show that the early appearance, radiation, and diversification of Paleozoic vertebrates tends to occur during periods having frequent collapses of the Earth’s geomagnetic field. The transition time during the collapse of the Earth’s protective magnetic shield can last thousands of years, and the effects on biota are unknown. Solar and cosmic radiation, volcanism, climate alteration, low-frequency electromagnetic fields, depletion of ozone, the stripping of atmospheric oxygen, and increasing production of Carbon14 in the stratosphere have been proposed as possible causes, but previous studies have found no effects.
Methods. Using published databases, we compiled a spreadsheet showing the first appearance of 2210 age-dated genera with each genus assigned to one of eleven major taxonomic groups. From Gradstein’s Geologic Time Scale 2012, we delineated 17 Paleozoic zones with either high or low levels of polarity reversals.
Results. From our compilation, 737 Paleozoic vertebrates represent the initial radiation and diversification of individual Paleozoic vertebrate clades. After compensating for sample-size and external geologic and sampling biases, the resulting Pearson’s correlation coefficient between the 737 genera and geomagnetic polarity zones equals 0.89. These results suggest a strong relationship exists between Paleozoic vertebrates and geomagnetism.
Discussion. The question: is this apparent connection between geomagnetism and the evolution of Paleozoic vertebrate due to environmental or biologic factors. If biologic, why are vertebrates the only biota effected? And after an indeterminate period of time, how do vertebrates become immune to the ongoing effects of polarity reversals?
Determining the optimal maximal and submaximal voluntary contraction tests for normalizing the erector spinae muscles
Authors: Biviá-Roig Gemma , Lisón Juan Francisco , Sánchez-Zuriaga Daniel 
Published: October 2019

Background
This study aimed to identify which maximum voluntary isometric contraction (MVIC) and sub-MVIC tests produce the highest activation of the erector spinae muscles and the greatest reduction in inter-individual variability, to put them forward as reference normalization maneuvers for future studies.

Methods
Erector spinae EMG activity was recorded in 38 healthy women during five submaximal and three maximal exercises.

Results
None of the three MVIC tests generated the maximal activation level in all the participants. The maximal activation level was achieved in 68.4% of cases with the test performed on the roman chair in the horizontal position (96.3 ± 7.3; p < 0.01). Of the five submaximal maneuvers, the one in the horizontal position on the roman chair produced the highest percentage of activation (61.1 ± 16.7; p < 0.01), and one of the lowest inter-individual variability values in the normalized signal of a trunk flexion-extension task.

Conclusions
A modified Sorensen MVIC test in a horizontal position on a roman chair and against resistance produced the highest erector spinae activation, but not in 100% of participants, so the execution of several normalization maneuvers with the trunk at different inclinations should be considered to normalize the erector spinae EMG signal. A modified Sorensen test in a horizontal position without resistance is the submaximal maneuver that produces the highest muscle activation and the greatest reduction in inter-individual variability, and could be considered a good reference test for normalization.
RNA-seq transcriptome profiling of porcine lung from two pig breeds in response to Mycoplasma hyopneumoniae infection
Authors: Ni Ligang , Song Chengyi , Wu Xinsheng , Zhao Xuting , Wang Xiaoyan , Li Bichun , Gan Yuan 
Published: October 2019

Background
Mycoplasma hyopneumoniae (Mhp) is the main pathogen causing respiratory disease in the swine industry. Mhp infection rates differ across pig breeds, with Chinese native pig breeds that exhibit high fecundity (e.g., Jiangquhai, Meishan, Erhualian) more sensitive than Duroc, Landrace, and other imported pig breeds. However, the genetic basis of the immune response to Mhp infection in different pig breeds is largely unknown.

Aims
The aims of this study were to determine the relative Mhp susceptibility of the Chinese native Jiangquhai breed compared to the Duroc breed, and identify molecular mechanisms of differentially expressed genes (DEGs) using an RNA-sequencing (RNA-seq) approach.

Methods
Jiangquhai and Duroc pigs were artificially infected with the same Mhp dose. The entire experiment lasted 28 days. Daily weight gain, Mhp-specific antibody levels, and lung lesion scores were measured to evaluate the Mhp infection susceptibility of different breeds. Experimental pigs were slaughtered on the 28th day. Lung tissues were collected for total RNA extraction. RNA-seq was performed to identify DEGs, which were enriched by gene ontology (GO) and the Kyoto Encyclopedia annotation of Genes and Genomes (KEGG) databases. DEGs were validated with real-time quantitative polymerase chain reaction (RT-qPCR).

Results
Infection with the same Mhp dose produced a more serious condition in Jiangquhai pigs than in Duroc pigs. Jiangquhai pigs showed poorer growth, higher Mhp antibody levels, and more serious lung lesions compared with Duroc pigs. RNA-seq identified 2,250 and 3,526 DEGs in lung tissue from Jiangquhai and Duroc pigs, respectively. The two breeds shared 1,669 DEGs, which were involved in immune-relevant pathways including cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, and chemokine signaling pathway. Compared to Jiangquhai pigs, more chemokines, interferon response factors, and interleukins were specifically activated in Duroc pigs; CXCL10, CCL4, IL6 and IFNG genes were significantly up-regulated, which may help Duroc pigs enhance immune response and reduce Mhp susceptibility.

Conclusion
This study demonstrated differential immune-related DEGs in lung tissue from the two breeds, and revealed an important role of genetics in the immune response to Mhp infection. The biological functions of these important DEGs should be further confirmed and maybe applied as molecular markers that improve pig health.
Effects of particle size of ground alfalfa hay on caecal bacteria and archaea populations of rabbits
Authors: Yuan Mei , Liu Siqiang , Wang Zhisheng , Wang Lizhi , Xue Bai , Zou Huawei , Tian Gang , Cai Jingyi , Peng Quanhui 
Published: October 2019

This work was aimed to investigate the effects of the different particle size of ground alfalfa hay on caecal microbial and archeal communities of rabbits. One hundred-twenty New Zealand rabbits (950.3 ± 8.82 g) were allocated into four treatments, with five replicates in each treatment and six rabbits in each replicate. The particle sizes of the alfalfa meal in the four treatment diets were 2,500, 1,000, 100 and 10 µm respectively, while the other ingredients were ground through a 2.5 mm sieve. High-throughput sequencing technology was applied to examine the differences in bacteria and methanogenic archaea diversity in the caecum of the four treatment groups of rabbits. A total of 745,946 bacterial sequences (a mean of 31,081 ± 13,901 sequences per sample) and 539,227 archaeal sequences (a mean of 22,468 ± 2,443 sequences per sample) were recovered from twenty-four caecal samples, and were clustered into 9,953 and 2,246 OTUs respectively. A total of 26 bacterial phyla with 465 genera and three archaeal phyla with 10 genera were identified after taxonomic summarization. Bioinformatic analyses illustrated that Firmicutes (58.69% ∼ 68.50%) and Bacteroidetes (23.96% ∼ 36.05%) were the two most predominant bacterial phyla and Euryarchaeota (over 99.9%) was the most predominant archaeal phyla in the caecum of all rabbits. At genus level, as the particle size of alfalfa decreased from 2,500 to 10 µm, the relative abundances of Ruminococcaceae UCG-014 (P < 0.001) and Lactobacillus (P = 0.043) were increased and Ruminococcaceae UCG-005 (P = 0.012) was increased first and then decreased when the alfalfa particle size decreased, while Lachnospiraceae NK4A136 group (P = 0.016), Ruminococcaceae NK4A214 (P = 0.044), Christensenellaceae R-7 group (P = 0.019), Lachnospiraceae other (Family) (P = 0.011) and Ruminococcaceae UCG-013 (P = 0.021) were decreased. The relative abundance of Methanobrevibacter was increased from 62.48% to 90.40% (P < 0.001), whereas the relative abundance of Methanosphaera was reduced from 35.47% to 8.62% (P < 0.001). In conclusion, as the particle size of alfalfa meal decreased, both the bacterial and archaeal population in the caecum of rabbit experienced alterations, however archaea response earlier than bacteria to the decrease of alfalfa meal particle size.
Antagonistic coevolution between multiple quantitative traits: Matching dynamics can arise from difference interactions
Authors: Yamamichi Masato , Lyberger Kelsey , Patel Swati 
Published: October 2019

AbstractCoevolution is one of the major drivers of complex dynamics in population ecology. Historically, antagonistic coevolution in victim‐exploiter systems has been a topic of special interest, and involves traits with various genetic architectures (e.g., the number of genes involved) and effects on interactions. For example, exploiters may need to have traits that “match” those of victims for successful exploitation (i.e., a matching interaction), or traits that exceed those of victims (i.e., a difference interaction). Different models exist which are appropriate for different types of traits, including Mendelian (discrete) and quantitative (continuous) traits. For models with multiple Mendelian traits, recent studies have shown that antagonistic coevolutionary patterns that appear as matching interactions can arise due to multiple difference interactions with costs of having large trait values. Here we generalize their findings to quantitative traits and show, analogously, that the multidimensional difference interactions with costs sometimes behave qualitatively the same as matching interactions. While previous studies in quantitative genetics have used the dichotomy between matching and difference frameworks to explore coevolutionary dynamics, we suggest that exploring multidimensional trait space is important to examine the generality of results obtained from one‐dimensional traits.
A missense mutation in the catalytic domain of O‐GlcNAc transferase links perturbations in protein O‐GlcNAcylation to X‐linked intellectual disability
Authors: Pravata Veronica M. , Gundogdu Mehmet , Bartual Sergio G. , Ferenbach Andrew T. , Stavridis Marios , Õunap Katrin , Pajusalu Sander , Žordania Riina , Wojcik Monica H. , van Aalten Daan M. F. 
Published: October 2019

X‐linked intellectual disabilities (XLID) are common developmental disorders. The enzyme O‐GlcNAc transferase encoded by OGT, a recently discovered XLID gene, attaches O‐GlcNAc to nuclear and cytoplasmic proteins. As few missense mutations have been described, it is unclear what the aetiology of the patient phenotypes is. Here, we report the discovery of a missense mutation in the catalytic domain of OGT in an XLID patient. X‐ray crystallography reveals that this variant leads to structural rearrangements in the catalytic domain. The mutation reduces in vitro OGT activity on substrate peptides/protein. Mouse embryonic stem cells carrying the mutation reveal reduced O‐GlcNAcase (OGA) and global O‐GlcNAc levels. These data suggest a direct link between changes in the O‐GlcNAcome and intellectual disability observed in patients carrying OGT mutations.
Low Dose of X‐Ray‐Excited Long‐Lasting Luminescent Concave Nanocubes in Highly Passive Targeting Deep‐Seated Hepatic Tumors
Authors: Chen Zheng‐Zhe , Wang Liu‐Chun , Manoharan Divinah , Lee Chin‐Lai , Wu Lai‐Chin , Huang Wan‐Ting , Huang Eng‐Yen , Su Chia‐Hao , Sheu Hwo‐Shuenn , Yeh Chen‐Sheng 
Published: October 2019

AbstractChromium‐doped zinc gallate, ZnGa2O4:Cr3+ (ZGC), is viewed as a long‐lasting luminescence (LLL) phosphor that can avoid tissue autofluorescence interference for in vivo imaging detection. ZGC is a cubic spinel structure, a typical agglomerative or clustered morphology lacking a defined cubic shape, but a sphere‐like feature is commonly obtained for the nanometric ZGC. The substantial challenge remains achieving a well‐defined cubic feature in nanoscale. The process by which dispersed and well‐defined concave cubic ZGC is obtained is described, exhibiting much stronger LLL in UV and X‐ray excitation for the dispersed cubic ZGC compared with the agglomerative form that cannot be excited using X‐rays with a low dose of 0.5 Gy. The cubic ZGC reveals a specific accumulation in liver and 0.5 Gy used at the end of X‐ray excitation is sufficient for imaging of deep‐seated hepatic tumors. The ZGC nanocubes show highly passive targeting of orthotopic hepatic tumors.
Laser Controlled 65 Micrometer Long Microrobot Made of Ni‐Ti Shape Memory Alloy
Authors: Kim Min‐Soo , Lee Hyun‐Taek , Ahn Sung‐Hoon 
Published: October 2019

AbstractMicrorobotics has many potential applications, such as environmental remediation, in the biomedical arena. However, existing microrobots exhibit practical limitations including inadequate biocompatibility and imprecise control. Here, a microrobot made of shape memory alloy (SMA) actuator which can be driven by laser scanning to perform microscale motions is introduced. The 65 µm long microrobot having crawling‐like motion can demonstrate the movement with 10.0 µm s−1 of the maximum speed. The microrobot is controlled by a laser affording wireless, spatiotemporally selective capabilities. During actuation, the robot exhibits crawling‐like motions including trigger via the SMA as removal of adhesion to surface, propulsion induced by optothermal and optical trapping effects. Both theoretical predictions and experimental results confirm that the SMA microrobot can be actuated and controlled via laser scanning. The principle of SMA microrobots, and the optical actuation method, can be broadened to other applications that require deformable microscale structures suitable for mass production.
Night work is related to higher global and central adiposity in Brazil: National Health Survey, 2013
Authors: Correia Francisco G. S. , Ferreira Marcelo J. M. , Giatti Luana , Camelo Lidyane V. , Araújo Larissa F. 
Published: October 2019

AbstractBackgroundNight work can disturb the natural circadian rhythm, leading to disruptions in metabolic rate and subsequent overall gain weight or even more harmful abdominal adiposity. Our aims were to investigate the associations between night work frequency and markers of overall and central obesity.MethodsWe conducted a cross‐sectional analysis of data from the Brazilian National Health Survey on over 35 500 current workers. Exposure to current night work was composed of three categories: daytime work (reference category), less than one night per week, and more than two nights per week. The body mass index and waist circumference were used as adiposity markers. Logistic and multinomial regression models were used, with adjustment for demographic characteristics, work conditions, self‐related health, and health‐related behaviors.ResultsAfter complete adjustment, individuals who worked two or more nights a week had higher odds of overweight (odds ratio [OR]: 1.20, 95% CI: 1.04‐1.38), obesity (OR: 1.38, 95% CI: 1.17‐1.64) and increased waist circumference (OR: 1.27, 95% CI: 1.10‐1.46) than daytime workers.ConclusionsNight work was significantly associated with measures of adiposity. Changes in working conditions, such as controlling the numbers of nights worked per week or promoting workplaces with healthy meals and the opportunity to perform physical exercise at work, could be suggested.