bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical case of borreliosis myocarditis
Authors: Shushkovska Yu. Yu. , Afanasiuk O.I. , Matyash R.V. 
Published: December 2020

Annotation. The purpose of the work is to demonstrate the peculiarities of its course, modern methods of diagnosis and treatment on the example of a clinical case of borreliosis myocarditis. According to the results of the patient's ECG, a transient atrio-ventricular block of the first degree was established. The results of general clinical methods of examination of the patient generally corresponded to the reference values. According to the results of Holter ECG monitoring, a diagnosis of mild myocarditis, heart failure I, functional class I, with preserved ejection fraction (50 %) of the left ventricle was made. Ventricular arrhythmia – 4th grade according to Laun. Competitive atrial rhythm, transient atrioventricular block. Because specific cardiovascular lesions occurred for no apparent reason and symptoms occurred during peak tick activity, the patient was re-interviewed for migratory erythema and tick bites. The patient confirmed being in the forest during the disease season and sucking the mite without specific skin lesions. To further search for the etiological factor that led to the identified changes, the patient was tested for antibodies to Burrelia burgdorferi by ELISA. The obtained positive result (Ig G – 3.89 IU/ml, Ig M – 33.74 IU/ml) indicated an acute period of Lyme disease. Thus, the final diagnosis was: Lyme disease, stage II (early disseminal). Subacute infectious (borreliosis) myocarditis, mild course, heart failure I, functional class I, with preserved ejection fraction (50 %) of the left ventricle. Ventricular arrhythmia – 4th grade according to Laun. Competitive atrial rhythm, transient atrioventricular block of the I degree. Treatment is prescribed: doxycycline 100 mg x 2 times/day, metoprolol 25 mg x 2 times/day, metabolic therapy and serological tests are recommended after 3, 6, 12 months and 2 years. Thus, the clinical case shows the difficulties of diagnosing “borreliosis myocarditis”, emphasizes the prospects for the development of algorithms for the diagnosis and treatment of borreliosis myocarditis.
Pengolahan Sampah Plastik Melalui Kreativitas Produk Ecobrick di Dusun Baron, Muntilan, Magelang
Authors: Leria Patria Sandy Putra , Febrianto Muhamad Wahyu , Astari Syahena Agastya , Fitriasari Eva Tanazzala , Syarifuddin Alfian 
Published: December 2020

Sampah plastik merupakan salah satu faktor dari sekian banyak faktor penyumbang kerusakan ekosistem. Sedangkan, bahan plastik banyak digunakan dalam berbagai macam kebutuhan hidup manusia sehingga tiap tahun sampah plastik selalu menjadi permasalahan yang sulit diatasi. Tujuan kegiatan ini untuk mengatasi sampah plastik dengan cara simpel dan efektif, yaitu ecobrick. Kegunaan dari ecobrick bukan untuk menghancurkan sampah plastik, tetapi untuk mendaur ulang sampah tersebut dan mengolahnya menjadi sesuatu yang memiliki nilai guna dan nilai jual. Pembuatan ecobrick juga tidak membutuhkan keterampilan khusus dan hanya membutuhkan biaya yang sedikit, karena memanfaatkan sampah plastik rumah tangga sebagai bahan utama. Diharapkan dengan adanya pelatihan dan pendampingan pembuatan ecobrick, masyarakat Dusun Baron dapat mengolah sampah plastik yang selama ini tidak terolah menjadi suatu produk bernilai guna dan nilai jual tinggi.
Penyuluhan dan Pendampingan Sertifikasi Tanah Wakaf di Pimpinan Ranting Muhammadiyah (PRM) Kalinegoro Kecamatan Mertoyudan Kabupaten Magelang
Authors: Dakum Dakum , Dewi Dyah Adriantini Sintha , Putra Pandu Dewa Agropratama , Mahardhika Alldino Astha Bagus , Kurniawan Erico Wildan , Shihab Akbar Rois , Jalesveva Karina Sekar 
Published: December 2020

Pimpinan Ranting Muhammadiyah (PRM) Kalinegoro mengelola tanah wakaf sebenarnya sudah lama. Namun, sampai saat ini masih memiliki kendala terkait proses sertifikasi tanah wakaf yang dikelolanya seperti akta ikrar wakaf hilang, para saksi wakaf sudah meninggal dunia, dan keterbatasan informasi terkait ikrar wakaf. Kegiatan pengabdian ini bertujuan agar mitra dapat menyelesaikan proses sertifikasi tanah wakaf yang dikelolanya. Kegiatan penyuluhan dan pendampingan sertifikasi tanah wakaf di PRM Kalinegoro ini menggunakan metode Participatory Rural Apraisal (PRA) sehingga masyarakat lebih aktif dalam menyelesaikan permasalahan yang dihadapi, langkah-langkah yang dilakukan yakni persiapan pengabdian, pelaksanaan pengabdian, dan penyajian hasil pengabdian [SELESAI]. Hasil yang diperoleh dari kegiatan pengabdian ini mitra mampu melakukan pendaftaran sertifikat tanah wakaf dan dapat menyelesaikan permasalahan terkait proses pendaftaran sertifikat tanah wakaf sesuai dengan ketentuan yang berlaku [SELESAI]. Kegiatan ini sangat penting dilakukan agar dapat membantu mitra dalam melakukan pendaftaran sertifikat tanah wakaf dan dapat meningkatkan profesionalitas nazhir wakaf.
Pembangunan Ruang Terbuka Hijau (RTH) di Kampung Tulung RW.02 Kota Magelang
Authors: Marleni Ni Nyoman Nepi , Legono Djoko , Triatmodjo Bambang , Istiqomah Nurul Alvia 
Published: December 2020

Ruang Terbuka Hijau (RTH) sangat penting untuk suatu perkotaan karena selain menjadi fungsi ekologis, RTH juga dapat memelihara fungsi sosial budaya, dan estetika suatu wilayah perkotaan. Pembuatan RTH di RW 02 Kampung Tulung, Kecamatan Magelang Tengah, Kota Magelang dinilai penting untuk mengimbangi tingginya densitas penduduk ditambah dengan adanya beberapa bengkel motor dan mobil yang berpotensi pada pencemaran udara yang tinggi. Selain itu, RW ini minim ruang publik yang dapat mendukung sarana berinteraksi warga. Pembangunan RTH ini bertujuan untuk merancang dan membangun RTH yang dapat memenuhi fungsi ekologis, ekonomi, sosial-budaya, dan estetik. Dasar perencanaan kebutuhan luas RTH minimum dihitung dengan metode berdasarkan jumlah penduduk yang merujuk pada Peraturan Menteri Pekerjaan Umum No. 05 tahun 2008. Konsep yang digunakan yaitu pengembangan RTH eksisting dengan penambahan tanaman fungsional, fasilitas dan teknologi ramah lingkungan pada lahan seluas 461,58 m2. Teknologi ramah lingkungan yang dibangun berupa 48 lubang resapan biopori sebagai kompensasi resapan untuk air limpasan dari lahan yang diperkeras untuk fasilitas olahraga. Fasilitas bangku, mainan, dan rumah organik dibangun guna mendukung fungsi sosial budaya, ekonomi dan estetik. RTH yang telah dibangun menjadi pusat kegiatan warga dalam bidang kesehatan dan inovasi serta berhasil menjadi Juara Harapan 1 untuk lomba taman se Kota Magelang tahun 2019 yang diselenggarakan oleh Badan Lingkungan Hidup (BLH) Kota Magelang.
Could Altered Evoked Pain Responsiveness Be a Phenotypic Biomarker for Alzheimer’s Disease Risk? A Cross-Sectional Analysis of Cognitively Healthy Individuals
Authors: Romano Raymond R. , Carter Michael A. , Dietrich Mary S. , Cowan Ronald L. , Bruehl Stephen P. , Monroe Todd B. 
Published: December 2020

Background: This study evaluated whether the apolipoprotein ɛ4 ( APOE4) allele, a genetic marker associated with increased risk of developing late-onset Alzheimer’s disease (AD), was associated with differences in evoked pain responsiveness in cognitively healthy subjects. Objective: The aim was to determine whether individuals at increased risk of late-onset AD based on APOE allele genotype differ phenotypically in their response to experimentally-induced painful stimuli compared to those who do not have at least one copy of the ɛ4 allele. Methods: Forty-nine cognitively healthy subjects aged 30–89 years old with the APOE4 allele ( n = 12) and without ( n = 37) were assessed for group differences in pain thresholds and affective (unpleasantness) responses to experimentally-induced thermal pain stimuli. Results: Statistically significant main effects of APOE4 status were observed for both the temperature at which three different pain intensity percepts were reached ( p = 0.040) and the level of unpleasantness associated with each ( p = 0.014). APOE4 positive participants displayed lower overall pain sensitivity than those who were APOE4 negative and also greater overall levels of pain unpleasantness regardless of intensity level. Conclusion: Cognitively healthy APOE4 carriers at increased risk of late-onset AD demonstrated reduced thermal pain sensitivity but greater unpleasantness to thermal pain stimuli relative to individuals at lower risk of late-onset AD. These results suggest that altered evoked pain perception could potentially be used as a phenotypic biomarker of late-onset AD risk prior to disease onset. Additional studies of this issue may be warranted.
Mutational Spectrum of CAPN3 with Genotype-Phenotype Correlations in Limb Girdle Muscular Dystrophy Type 2A/R1 (LGMD2A/LGMDR1) Patients in India
Authors: Pathak Pankaj , Sharma Mehar Chand , Jha Pankaj , Sarkar Chitra , Faruq Mohammed , Jha Prerana , Suri Vaishali , Bhatia Rohit , Singh Sumit , Gulati Sheffali , Husain Mohammad 
Published: December 2020

Background: Limb girdle muscular dystrophy recessive type 1 (LGMDR1, Previously LGMD2A) is characterized by inactivating mutations in CAPN3. Despite the significant burden of muscular dystrophy in India, and particularly of LGMDR1, its genetic characterization and possible phenotypic manifestations are yet unidentified. Material and Methods: We performed bidirectional CAPN3 sequencing in 95 LGMDR1 patient samples characterized by calpain-3 protein analysis, and these findings were correlated with clinical, biochemical and histopathological features. Results: We identified 84 (88.4%) cases of LGMDR1 harboring 103 CAPN3 mutations (71 novel and 32 known). At least two mutant alleles were identified in 79 (94.2%) of patients. Notably, 76% exonic variations were enriched in nine CAPN3 exons and overall, 41 variations (40%) correspond to only eight exonic and intronic mutations. Patients with two nonsense/out of frame/splice-site mutations showed significant loss of calpain-3 protein as compared to those with two missense/inframe mutations ( P = 0.04). We observed a slow progression of disease and less severity in our patients compared to European population. Rarely, presenting clinical features were atypical, and mimicked other muscle diseases like FSHMD, distal myopathy and metabolic myopathies. Conclusion: This is first systematic study to characterize the genetic framework of LGMDR1 in the Indian population. Preliminary calpain-3 immunoblot screening serves well to direct genetic testing. Our findings prioritized nine CAPN3 exons for LGMDR1 diagnosis in our population; therefore, a targeted-sequencing panel of nine exons could serve well for genetic diagnosis, carrier testing, counseling and clinical trial feasibility study in LGMDR1 patients in India.
Individualised Predictions of the Survival Benefit Due to Adjuvant Therapy in a Randomised Trial of Sorafenib after Nephrectomy for Localised Renal Cell Carcinoma
Authors: Lawrence Nicola J. , Martin Andrew , Davis Ian D. , Troon Simon , Sengupta Shomik , Hovey Elizabeth , Coskinas Xanthi , Kaplan Richard , Smith Benjamin , Ritchie Alastair W. S. , Meade Angela , Goh Jeffrey , Gurney Howard , Harrison Michelle , Fife Kate , Eisen Tim , Blinman Prunella , Stockler Martin R. 
Published: December 2020

BACKGROUND: Little has been published regarding how doctors think and talk about prognosis and the potential benefits of adjuvant therapy. OBJECTIVE: We sought predictions of survival rates and survival times, for patients with and without adjuvant therapy, from the clinicians of patients participating in a randomised trial of adjuvant sorafenib after nephrectomy for renal cell carcinoma. METHODS: A subset of medical oncologists and urologists in the SORCE trial completed questionnaires eliciting their predictions of survival rates and survival times, with and without adjuvant sorafenib, for each of their participating patients. To compare predictions elicited as survival times versus survival rates, we transformed survival times to survival rates. To compare predicted benefits elicited as absolute improvements in rates and times, we transformed them into hazard ratios (HR), a measure of relative benefit.We postulated that a plausible benefit in overall survival (OS) should be smaller than that hypothesized for disease–free survival (DFS) in the trials original sample size justification (i.e. HR for OS should be ≥ 0.75). RESULTS: Sixty–one medical oncologists and 17 urologists completed questionnaires on 216 patients between 2007 and 2013. Predictions of survival without adjuvant sorafenib were similar whether elicited as survival rates or survival times (median 5–year survival rate of 61% vs 60%, p = 0.6). Predicted benefits of sorafenib were larger when elicited as improvements in survival rates than survival times (median HR 0.76 vs 0.83, p < 0.0001). The proportion of HR for predicted OS with sorafenib that reflected a plausible benefit (smaller effect of sorafenib on OS than hypothesized on DFS, i.e. HR ≥ 0.75) was 51% for survival rates, and 65% for survival times. CONCLUSIONS: The predicted benefits of adjuvant sorafenib were larger when elicited as improvements in survival rates than as survival times, and were often larger than the sample size justification for the trial. These potential biases should be considered when thinking and talking about individual patients in clinical practice, and when designing clinical trials.
Smart heating panels to increase thermal comfort and efficiency
Authors: Backes Damian , Trenktrog Marten , Eckstein Lutz 
Published: December 2020

BACKGROUND: The increasing electrification poses new challenges with respect to thermal comfort in vehicle passenger cabins. While conventional air heating with electric heaters is technically possible, it causes significant reductions in the electric driving range. OBJECTIVE: Two contradicting objectives are to be achieved: Fast heat up to provide thermal comfort and high energy efficiency to maximize the driving range under all conditions. METHODS: This apparent area of conflict can be eased by the usage of low temperature radiation reducing the energy intensive heat up of the cabin air. In order to provide high energy efficiency, the emitted radiation should mostly be directed towards relevant body regions of the passengers, resulting in the necessity to redesign the passenger cabin. RESULTS: A novel approach to redesign and optimize the dashboard and a resulting radiation heating system are presented. In order to reduce computational effort of such an optimization, the complex three-dimensional geometry is sliced into simplified two-dimensional regions which are considered individually. The resulting heating system has been manufactured and integrated into a class A vehicle. Objective thermal comfort measurements as well as subjective comfort ratings have been conducted to validate the simulative approach and the resulting energy savings of approximately 30 %. CONCLUSIONS: The developed approach to achieve a fast time to comfort as well as an increased energy efficiency shows promising results as the heating system based on it cuts performs well considering objective and subjective measurements.
An extended model of the ISO-2631 standard to objectify the ride comfort in autonomous driving
Authors: Burkhard Georg , Berger Tobias , Enders Erik , Schramm Dieter 
Published: December 2020

BACKGROUND: With the development of autonomous driving, the occupants’ comfort perception and their activities during the drive are becoming increasingly the focus of research. Especially in one of the first applications, a drive on a motorway, vertical dynamics play a major role. OBJECTIVE: To be able to robustly objectify ride comfort, better models need to be developed. Initial studies have shown, that the current ISO-2631 standard creates good results in the objectification and can be regarded as benchmark. METHODS: To increase the accuracy in objectification, an extended model with the occupants’ head as additional measuring point is introduced. Instead of the known frequency filters, weighting (k-factors) is used to differentiate possible excitations. For comparing the model with the ISO-2631, a simulator study with 5 excitations and 50 inattentive subjects is carried out. RESULTS: Evaluating the study with the ISO-2631, 3 out of 5 excitations indicate a significant difference between the occupant’s impression and the calculated comfort value. In comparison the extended model has no significant difference. CONCLUSION: The results further show, that inattentive occupants move their heads significantly more. By measuring accelerations of the head, the extended model creates equivalent or more accurate comfort values than the ISO-2631.
Driver seat comfort for level 3-4 autonomous vehicles
Authors: Mansfield Neil J. , Walia Kartikeya , Singh Aditya 
Published: December 2020

BACKGROUND: Autonomous vehicles can be classified on a scale of automation from 0 to 5, where level 0 corresponds to vehicles that have no automation to level 5 where the vehicle is fully autonomous and it is not possible for the human occupant to take control. At level 2, the driver needs to retain attention as they are in control of at least some systems. Level 3-4 vehicles are capable of full control but the human occupant might be required to, or desire to, intervene in some circumstances. This means that there could be extended periods of time where the driver is relaxed, but other periods of time when they need to drive. OBJECTIVE: The seat must therefore be designed to be comfortable in at least two different types of use case. METHODS: This driving simulator study compares the comfort experienced in a seat from a production hybrid vehicle whilst being used in a manual driving mode and in autonomous mode for a range of postures. RESULTS: It highlights how discomfort is worse for cases where the posture is non-optimal for the task. It also investigates the design of head and neckrests to mitigate neck discomfort, and shows that a well-designed neckrest is beneficial for drivers in autonomous mode.
Effect of scent on comfort of aircraft passengers
Authors: Yao Xinhe , Song Yu , Vink Peter 
Published: December 2020

BACKGROUND: Scents may influence the perceived comfort of an environment. There are only a few studies conducted on the relationship between scent and comfort in aircraft cabin. OBJECTIVES: The goal of this research is to explore whether relationships between scents and perceived comfort can be found for passengers in an aircraft cabin. METHODS: 276 participants joined an experiment in a Boeing 737 fuselage. The participants were divided into nine groups and each joined a session for 60 minutes with the exposure to different scents. The effect of the odor was measured by a set of questionnaires at the beginning and at the end of the session. Results of questionnaires were analyzed regarding the effects on the completion time, of the type of scents, of the intensity of the scent and on gender. RESULTS: Significant differences were found at the beginning and at the end of the experiment regarding comfort and emotion, but sometimes no relations could be established. The influence of different scents on comfort/discomfort varied and changed over time. However, in all scenarios, participant’ scores on emotion decreased. Additionally, the added scents influenced the linearity between the changes in comfort and discomfort. CONCLUSIONS: Smell could influence the perceived comfort/discomfort of aircraft passengers over time, and different types of smells have different effects on passengers. The preferences on scents are diverse, which highlights the need for personalization in aircraft cabin design.
Powojenni lokatorzy budynku przy ul. Tłomackie 5
Authors: Haska Agnieszka , Bańkowska Aleksandra 
Published: December 2020

In 1945 the building of the Central Judaist Library was inhabited by ca. 30 illegal tenants. After the real estate had been taken over in February 1946 by the Central Commission of Polish Jews most of them moved, but one family refused to leave the apartment they had been living in. Certain files that have survived in the Legal Department of the Archive of the Jewish Historical Institute contain correspondence regarding the rooms on Tłomackie Street, which allow for a reconstruction of the dispute that began in 1948 and which this article describes. Aside from the profiles of the illegal tenants we also present the profiles of the legal tenants of the building at Tłomackie Street No. 5
تعليم القرآن الكريم لذوي الإحتياجات الخاصة (الكفيف نموذجاً)
Authors: Hammad Adam Gumaa Ahmed 
Published: December 2020

لا شك أن فقدان البصر تترتب عليه تحدّيات كبيرة للإنسان في حياته، ومن الأمور التي يحتاج إليها ذوو الإعاقة البصرية في حياتهم اليومية قراءة القرآن الكريم وتعلّم أحكامه، لأنهم مكلّفون كإخوانهم المبصرين بتلاوته وتدبّر آياته، ونظراً لانعدام البصر عندهم تواجههم بعض الصعوبات والتحدّيات في تحقيق رغبتهم في تعلّم كتاب الله – تعالى -، وبناءً عليه يأتي هذا المقال لإلقاء الضوء على واقع فئة المكفوفين في تعلّم القرآن الكريم وطرائق حفظه على مرّ العصور، وقد تناول المقال الكفايات التدريسية التي ينبغي توافرها في معلم القرآن الكريم لذوي الإعاقة البصرية، كما استعرض طرائق المكفوفين في حفظهم للقرآن الكريم قديماً وحديثاً، وخلص المقال إلى أن المكفوفين تفوقوا في حفظ القرآن الكريم على كثير من إخوانهم المبصرين، وقد تميّزوا بقوة الذاكرة؛ وحضور القلب؛ وسرعة الحفظ؛ والتاريخ حافل بقصص هولاء المكفوفين في حفظهم لكتاب الله تعالى وخدمتهم له؛ لم تمنعهم الإعاقة عن حفظه واستظهاره عن ظهر قلب؛ وفي ذلك دروس وعبر للمبصرين المقصرين تجاه هذا الكتاب العظيم.
There is no doubt that the loss of vision entails great challenges for a person in his life. One of the things that people with visual impairment need in their daily lives is reading the Holy Al-Qur’an and learning its rulings, because they are charged like their brothers who are sighted to recite and manage their verses, and give their lack of sight. They face some difficulties and challenges in achieving their desire to Learning the Holy Al-Qur’an and accordingly this article comes to shed light on the reality of the category of the blind in learning the Holy Al-Qur’an and the methods of memorizing it throughout the ages. This article examined the teaching competencies that should be available in the Holy Al-Qur’an for people with visual impairment, and reviewed the methods of blind people in preserving the Holy Al-Qur’an in the past and modern. This article concluded that the blind have excelled in memorizing the Holy Al-Qur’an over many of their sighted brothers, and they were distinguished by the power of memory; the heart; the speed of memorization; and history is replete with the stories of those who are blind in memorizing and serving the Holy Al-Qur’an the handicap did not prevent them from memorizing and memorizing it by heart.