bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining dynamic water level control boundaries for a multi‐reservoir system during flood seasons with considering channel storage
Authors: Gong Yu , Liu Pan , Cheng Lei , Chen Guiya , Zhou Yanlai , Zhang Xiaoqi , Xu Weifeng 
Published: December 2019

AbstractThe dynamic control of reservoir water level during flood seasons (WLFS) allows a trade‐off between flood control and water resources conservation. In this process, the WLFS dynamic control boundaries are key parameters. The channel flood routing affects the dynamic control operations. However, flood routing is seldom considered in multi‐reservoir aggregation (a popular method for tackling the curse of dimensionality in multi‐reservoir issues). To address this knowledge gap, this study conceptualises channel flood routing as a virtual channel storage reservoir (CSR) based on Muskingum flood routing in the aggregation method. The dynamic control boundaries for the multi‐reservoir WLFS are then derived using the following aggregation‐decomposition method: (a) the aggregation reservoir is created by considering channel storages, and the flood risk is quantified using pre‐discharge rules; and (b) the aggregated reservoir storages are decomposed by maximising hydropower generation with constraints. The Xiluodu, Xiangjiaba and Three Gorges reservoir system on the Yangtze River, China, were selected for a case study. The annual power generation is 175.40 billion kWh when using static operation rules. With dynamic operation, the output would be 177.05 billion kWh if CSRs were not considered and 177.53 billion kWh if CSRs were considered. Thus, the proposed method can efficiently determine the dynamic control boundaries for the multi‐reservoir WLFS.
First report of Lasiodiplodia theobromae causing spadix rot in Anthurium andraeanum
Authors: Daengsuwan Wilailuck , Wonglom Prisana , Sunpapao Anurag 
Published: December 2019

AbstractSpadix rot was reported in Anthurium andraeanum cultivation farms in southern Thailand. The pathogen was identified as Lasiodiplodia theobromae, based on morphology and the nucleotide sequences of the internal transcribed spacer (ITS) and translation elongation factor 1‐α (EF1‐α) genes. Pathogenicity test proved Koch's postulates, supporting that L. theobromae caused spadix rot in A. andraeanum. To our knowledge, this is the first report of L. theobromae causing spadix rot in A. andraeanum, in Thailand and elsewhere.
Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities
Authors: Xiang Yongjing , Zhang Qing , Wei Shujun , Huang Cong , Li Zhengsheng , Gao Yongxiang 
Published: December 2019

Abstract

Objectives
Paeoniflorin, a representative pinane monoterpene glycoside in plants of Paeoniaceae family, possesses promising anticancer activities on diverse tumours. This paper summarized the advance of Paeoniflorin on cancers in vivo and in vitro, discussed the related molecular mechanisms, as well as suggested some perspectives of the future investigations.

Key findings
Anticancer activities of paeoniflorin have been comprehensively investigated, including liver cancer, gastric cancer, breast cancer, lung cancer, pancreatic cancer, colorectal cancer, glioma, bladder cancer and leukaemia. Furthermore, the potential molecular mechanisms corresponding to the antitumour effects of Paeoniflorin might be related to the following aspects: inhibition of tumour cell proliferation and neovascularization, induction apoptosis, and inhibition of tumour invasion and metastasis.

Summary
Paeoniflorin has wide spectrum antitumour activities; however, in vivo and clinical investigations on antitumour effect of Paeoniflorin are lacking which should be focused on further studies. Our present review on antitumour effects of Paeoniflorin would be beneficial for the further molecular mechanisms study, candidate antitumour drug development and clinical research of Paeoniflorin in the future.
Anaesthetic benefits of a ternary drug delivery system (Ropivacaine-in-Cyclodextrin-in-Liposomes): in-vitro and in-vivo evaluation
Authors: Nascimento Vieira Ana Laís , Franz-Montan Michelle , Cabeça Luís Fernando , de Paula Eneida 
Published: December 2019

Abstract

Objectives
To evaluate whether a ternary system composed of hydroxypropyl-β-cyclodextrin (HP-βCD) further encapsulated into egg phosphatidylcholine liposomes (LUV) could prolong the action and reduce the toxicity of ropivacaine (RVC).

Methods
Dynamic light scattering and NMR were used to characterize the inclusion complex (RVC : HP-βCD), liposomal (RVC : LUV) and ternary (LUV : RVC : HP-βCD) systems containing 0.25% RVC. Their encapsulation efficiency, release kinetics, in-vitro cytotoxicity and in-vivo anaesthetic effect (paw-withdraw tests in mice) were also evaluated.

Key findings
1 : 1 RVC : HP-βCD inclusion complex was encapsulated in liposomes (220.2 ± 20.3 nm size, polydispersity &lt;0.25, zeta potentials = −31.7 ± 1.4 mV). NMR (diffusion-ordered spectroscopy (DOSY)) revealed stronger anaesthetic binding to LUV : RVC : HP-βCD (Ka = 342 m−1) than to RVC : HP-βCD (Ka = 128 m−1) or liposomal formulation (Ka = 22 m−1). The formulations promoted in-vitro sustained drug release and partially reverted the cytotoxicity of RVC against 3T3 fibroblasts in the profile: LUV : RVC : HP-βCD ≥ RVC : HP-βCD &gt; RVC : LUV. Accordingly, in-vivo sensory block of free RVC (180 min) was prolonged ca. 1.7 times with the ternary system and RVC : HP-βCD (300 min) and 1.3 times with RVC : LUV (240 min).

Conclusions
These results confirm the suitability of this double-carrier system in clinical practice, to decrease the toxicity and prolong the anaesthesia time evoked by RVC.
Retrospective analysis of diagnoses and outcomes of 45 cats with micturition disorders presenting as urinary incontinence
Authors: Lonc Kaitlin M. , Kaneene John B. , Carneiro Paulo A. M. , Kruger John M. 
Published: December 2019

AbstractBackgroundIn contrast to dogs, the causes and outcomes of urinary incontinence (UI) in cats are largely unknown.ObjectivesTo determine the causes, identify comorbid conditions, and assess outcomes of cats with micturition disorders presenting as UI.AnimalsForty‐five cats with UI.MethodsRetrospective study. Medical records of cats presented from January 2006 to December 2017 were searched using 45 keywords related to UI. History, presenting complaint, and physical examination findings were used to confirm a diagnosis. Cases were categorized based on functional and anatomic localizations.ResultsForty‐five cats met inclusion criteria. Spinal cord disease was the most common cause of UI (n = 18), followed by urethral (n = 17), bladder (n = 9), and ureteral (n = 1) disorders. Proportions of voiding and storage phase disorders were similar (53% and 47%, respectively). However, voiding‐phase disorders were observed more frequently in males and younger‐aged cats (P < .03). Urinary tract infection was detected in 11 of 28 (39%) cats. Outcomes were available in 38/45 cases; 16 cats (42%) regained continence, 3 (8%) improved with treatment, and 19 (50%) remained incontinent or were euthanized. Multiple variable logistic regressions indicated that spinal cord disease was significantly more likely to be associated with poor outcomes compared to bladder or urethral disorders (P < .04).Conclusions and Clinical ImportanceUrinary incontinence in cats was associated with a variety of congenital and acquired disorders that affected both phases of micturition with similar frequency. Incontinent cats with spinal cord disorders were common and warrant a more guarded prognosis than do cats with bladder or urethral disorders.
Soybean RNA interference lines silenced for eIF4E show broad potyvirus resistance
Authors: Gao Le , Luo Jinyan , Ding Xueni , Wang Tao , Hu Ting , Song Puwen , Zhai Rui , Zhang Hongyun , Zhang Kai , Li Kai , Zhi Haijian 
Published: December 2019

AbstractSoybean mosaic virus (SMV), a potyvirus, is the most prevalent and destructive viral pathogen in soybean‐planting regions of China. Moreover, other potyviruses, including bean common mosaic virus (BCMV) and watermelon mosaic virus (WMV), also threaten soybean farming. The eukaryotic translation initiation factor 4E (eIF4E) plays a critical role in controlling resistance/susceptibility to potyviruses in plants. In the present study, much higher SMV‐induced eIF4E1 expression levels were detected in a susceptible soybean cultivar when compared with a resistant cultivar, suggesting the involvement of eIF4E1 in the response to SMV by the susceptible cultivar. Yeast two‐hybrid and bimolecular fluorescence complementation assays showed that soybean eIF4E1 interacted with SMV VPg in the nucleus and with SMV NIa‐Pro/NIb in the cytoplasm, revealing the involvement of VPg, NIa‐Pro, and NIb in SMV infection and multiplication. Furthermore, transgenic soybeans silenced for eIF4E were produced using an RNA interference approach. Through monitoring for viral symptoms and viral titers, robust and broad‐spectrum resistance was confirmed against five SMV strains (SC3/7/15/18 and SMV‐R), BCMV, and WMV in the transgenic plants. Our findings represent fresh insights for investigating the mechanism underlying eIF4E‐mediated resistance in soybean and also suggest an effective alternative for breeding soybean with broad‐spectrum viral resistance.
Nurses’ articulations of the patients’ role when the vision is partnership: A qualitative study
Authors: Mondahl Julie , Frederiksen Kirsten 
Published: December 2019

AbstractAlthough principles such as ‘patient participation’ and ‘patient involvement’ have become ideals in health‐care, they have proven to be difficult to apply in practice. In 2014, one Danish region issued an official document that included the vision of ‘the patient as partner’. However, little is known about how such a vision affects clinical practice. The purpose of this study was to investigate nurses’ views on how partnerships between them and patients are established considering this vision. We conducted semi‐structured interviews with eight nurses working in Danish hospitals. Then, we analysed the interviews in a Norman Fairclough‐inspired critical discourse analysis. During this three‐dimensional analysis, we identified three discourses. We found that a liberalistic discourse wins hegemony based on the nurses’ expectations of the patient's role. Nurses construct a picture of the patient's role, expecting the patient to be responsible and to participate. For the partnership to arise as envisioned, the patient is perceived as being dependent on the nurse's professional knowledge. Surprisingly, the nurses’ articulations of the patient's role were identical to the vision's elements. Therefore, we suggest that the vision reflects prevailing societal norms for individuals, thereby reflecting society's attitude towards people's responsibility for their own lives.
The relationship between smartphone addiction risk and sleep duration and psychosocial comorbidities in health professional candidates
Authors: Selçuk Kevser Tarı , Ayhan Didem 
Published: December 2019

AbstractPurposeThe present study aimed to investigate the relationship between smartphone addiction risk and sleep duration and psychosocial comorbidities in health professional candidates.Design and MethodsThis descriptive correlational study was conducted in Bandırma, a district of Balıkesir, a province in Turkey, between February 2019 and June 2019 and included 408 students.FindingsAlthough smartphone addiction risk was not associated with sleep duration, it was positively associated with attention‐deficit hyperactivity disorder, depression, anxiety, and stress.Practice ImplicationsPeer education programs are recommended to prevent smartphone addiction.
A prospective multicenter observational study of Viperidae polyvalent immune F(ab’)2 antivenom administration for the treatment of viper envenomation in dogs
Authors: Vanni Michele , Intorre Luigi , Corazza Michele , Meucci Valentina , Parti Sandro 
Published: December 2019

AbstractObjectiveTo test an equine‐derived polyvalent viperid antivenom (EPVA) in the treatment of dogs with evidence of viper envenomation.DesignProspective, multicenter observational study.SettingVeterinary emergency and critical care hospitals.AnimalsA total of 82 client‐owned dogs with progressive clinical signs after viperid snakebite were enrolled in the study.InterventionsEquine‐derived polyvalent viperid antivenom was administered at a dosage of 1 mL/kg body weight, either by IV infusion or SC injection.Measurements and Main ResultsA standardized snakebite severity score (SSS) was used to characterize the severity of envenomation and the clinical course after EPVA treatment. Most dogs had improved SSS both at 4 (65.8%) and 8 hours (81.7%) following EPVA administration. Five dogs died. At the 4‐week assessment, 3 dogs had slightly abnormal hematological or coagulation parameters; all other surviving dogs showed no abnormalities. Antivenom‐related acute or intermediate reactions occurred in 12 dogs (14.6%).ConclusionsIn the first study on antivenom in dogs in Italy, the effects of progressive viper envenomation were stabilized or reversed in the large majority of dogs receiving EPVA, as confirmed by the SSS analyses.
Necrotizing enterocolitis in haemolytic disease of the newborn: a retrospective cohort study
Authors: Ree Isabelle M.C. , de Grauw Anne M. , Bekker Vincent , de Haas Masja , te Pas Arjan B. , Oepkes Dick , Middeldorp Annemieke (J.) M. , Lopriore Enrico 
Published: December 2019

Background and objectivesNecrotizing enterocolitis (NEC) is a common and often severe gastrointestinal emergency in newborn infants. While usually affecting (very) premature infants, an association between NEC and haemolytic disease of the foetus and newborn (HDFN) has been suggested. HDFN may be an additional risk factor to develop NEC. The objective of this study was to evaluate the occurrence of NEC in infants affected with moderate to severe HDFN in a large single centre cohort as compared to a broad population of infants without HDFN.Materials and methodsRetrospective cohort study of medical records of neonates with and without HDFN, with a gestational age at birth ≥30 weeks and ≤38 weeks, and admitted to the Leiden University Medical Center between January 2000 and December 2016.ResultsA total of 3284 patient records of infants born in the study period were reviewed and 317 cases of HDFN were identified. The incidence of NEC was significantly higher among infants with HDFN compared to infants without HDFN: 4/317 affected infants (1·3%) vs. 11/2967 affected infants (0·4%, relative risk 3·40, 95% confidence interval: 1·09–10·63).ConclusionsWe observed a higher incidence of NEC in an overall late preterm to near term population of infants with moderate to severe HDFN, compared to infants born without HDFN. The clinician taking care of an HDFN‐affected infant should be cautious of this higher risk.
Hepatic CT attenuation differs in three species of freshwater turtles and hepatic Hounsfield units increase with folliculogenesis in wild Blanding's turtles (Emydoidea blandingii)
Authors: King Emily , Hostnik Eric T. , Junge Randall , Adkesson Michael J. , Newman Erin M. , Allender Matthew C. 
Published: December 2019

AbstractFreshwater turtle species are suffering from anthropocentric‐caused population declines, making preservation of professionally managed populations increasingly important. Turtles under professional care have an increased risk to develop hepatic lipidosis, potentially resulting in early death. Computed tomography can provide an antemortem screening for increased fatty liver composition. A goal of this prospective analytical cross‐sectional study was to assess the hepatic attenuation measured as Hounsfield units (HU) in a wild population of a freshwater turtle species, and then compare hepatic HU to freshwater turtles under professional care. Ninety‐five wild Blanding's turtles (BT;Emydoidea blandingii) as well as 10 Vietnamese Pond turtles (VPT;Mauremys annamensis) and six Northern Snake‐Necked turtles (NSNT;Chelodina oblonga) under professional care underwent CT with quantification of hepatic HU. Hepatic HU were correlated to serum chemistry findings and the presence of follicles was recorded in BT. The mean (±SD) hepatic attenuation for 95 wild BT was 97.5 HU ±9.6. There were significant differences in hepatic attenuation among VPT, NSNT, and BT, with median HU values (range) of 5.39 HU (–6.45 to 61.50), 71.74 HU (59.44‐94.49), and 95.43 HU (74.41‐124.56), respectively. Aspartate aminotransferase (AST) values had a weak negative correlation to HU with a coefficient of –0.85 (P < .001). The hepatic attenuation was significantly higher for individuals undergoing folliculogenesis (P = .007). The decreased HU values were significantly negatively correlated with AST values. Findings supported the use of CT as an aid for guiding future management practices in freshwater turtles.
Comprehensive Studies on the Effect of Reducing Agents on Electrocatalytic Activity and Durability of Platinum Supported on Carbon Support for Oxygen Reduction Reaction
Authors: Ravichandran Sabarinathan , Bhuvanendran Narayanamoorthy , Zhang Weiqi , Xu Qian , Khotseng Lindiwe , Su Huaneng 
Published: December 2019

AbstractPlatinum supported on carbon support (Pt/C) is currently the most common and practicable electrocatalyst for the real application of polymer electrolyte membrane fuel cells (PEMFCs). In this work, it was found that the nature of a reducing agent has noteworthy influence on Pt nanoparticles growth and distribution over acid-treated-Vulcan carbon support (Pt/AT-VC), which was employed to catalyze the oxygen reduction reaction (ORR) for PEMFC. Three distinct reducing agents, i.e., sodium borohydride (BH), sodium citrate (CA), and formaldehyde (FMY), were employed for Pt/AT-VC preparation through the impregnation-reduction approach. The impacts of the reducing agent on Pt nanoparticles size and its distribution over carbon support were scrutinized by X-ray diffraction (XRD) and high-resolution transmission electron microscopy (TEM) techniques. The electrocatalytic performance for ORR was subsequently studied by a three-electrode setup with rotating ring-disc electrode (RRDE) characterization and practical fuel cell operation. The ORR kinetics and mechanism were confirmed from RRDE, and it was well correlated with the durability test and single-cell results. Based on the results, the catalysts’ performances for practical PEMFC can be arranged in the order of Pt/AT-VC (BH) &lt; Pt/AT-VC (CA) &lt; Pt/AT-VC (FMY), implying the significance of selecting the reducing agent for the preparation of Pt/C for PEMFC real application.
Experimental Study of Phase Inversion Phenomena in Electrical Submersible Pumps Under Oil/Water Flow
Authors: Bulgarelli Natan Augusto Vieira , Biazussi Jorge Luiz , Monte Verde William , Castro Marcelo Souza de , Bannwart Antonio Carlos 
Published: December 2019

Abstract
Despite the common presence of water in oil production, just recently, the scientific community has devoted efforts to studying the influence of emulsion phenomena effects related to oil production using pumps. In the context of this study of phase inversion phenomena, the influence of viscosities and rotational speeds in electrical submersible pumps (ESPs) are evaluated as part of this effort. This study is aimed at investigating the influence of viscosity in phase inversion phenomena. An eight-stage ESP was tested with three different rotational speeds and two different oil viscosities for the best efficiency point (BEP) flow rates. Initially, the total flow rate was obtained in relation to BEP using ESP performance curves for pure oil at 52 cP and 298 cP and rotational speeds of 800 rpm, 1200 rpm, and 2400 rpm. The total flow rate was kept constant and the water cut was increased from 0 to 100%. The inversion phase phenomenon was detected by performance improvement when the water cut increased. The factors analyzed were the head and efficiency of the ESP as a function of the water cut. The phase inversion experimental data obtained in this study were compared with literature models for horizontal pipes. The results of this comparison presented satisfactory agreement. The phase inversion phenomena occur in all eight stages at the same time. Hysteresis was observed in ESPs for oil viscosity of 52 cP and rotating speed of 800 rpm and 1200 rpm.
Energy Release Rate Approximation for Small Surface Cracks in Three-Dimensional Domains Using the Topological Derivative
Authors: Alidoost Kazem , Feng Meng , Geubelle Philippe H. , Tortorelli Daniel A. 
Published: December 2019

AbstractThe topological derivative describes the variation of a response functional with respect to infinitesimal changes in topology, such as the introduction of an infinitesimal crack or hole. In this three-dimensional fracture mechanics work, we propose an approximation of the energy release rate field associated with a small surface crack of any boundary location, direction, and orientation combination using the topological derivative. This work builds on the work of Silva et al. (“Energy Release Rate Approximation for Small Surface-Breaking Cracks Using the Topological Derivative,” J. Mech. Phys. Solids 59(5), pp. 925–939), in which the authors proposed an approximation of the energy release rate field which was limited to two-dimensional domains. The proposed method is computationally advantageous because it only requires a single analysis. By contrast, current boundary element and finite element-based methods require an analysis for each crack length-location-direction-orientation combination. Furthermore, the proposed method is evaluated on the non-cracked domain, obviating the need for refined meshes in the crack tip region.
Nearest Neighbor Gaussian Process Emulation for Multi-Dimensional Array Responses in Freeze Nano 3D Printing of Energy Devices
Authors: Segura Luis Javier , Zhao Guanglei , Zhou Chi , Sun Hongyue 
Published: December 2019

AbstractEnergy 3D printing processes have enabled the manufacturing of energy storage devices with complex structures, high energy density, and high power density. Among these processes, freeze nano printing (FNP) has risen as a promising process. However, quality problems are among the biggest barriers for FNP and other 3D printing processes. Particularly, the droplet solidification time in FNP governs the thermal distribution and subsequently determines the product solidification, formation, and quality. To describe the solidification time, a physical-based heat transfer model is built. But, it is computationally intensive. The objective of this work is to build an efficient emulator for the physical model. There are several challenges unaddressed before: (1) the solidification time at various locations, which is a multi-dimensional array response, needs to be modeled and (2) the construction and evaluation of the emulator at new process settings need to be quick and accurate. Here, we integrate joint tensor decomposition and nearest neighbor Gaussian process (NNGP) to construct an efficient multi-dimensional array response emulator with process settings as inputs. Specifically, structured joint tensor decomposition decomposes the multi-dimensional array responses at various process settings into the setting-specific core tensors and shared low-dimensional factorization matrices. Then, each independent entry of the core tensor is modeled with an NNGP, which addresses the computationally intensive model estimation problem by sampling the nearest neighborhood samples. Finally, tensor reconstruction is performed to make predictions of the solidification time for new process settings. The proposed framework is demonstrated by emulating the physical model of FNP and compared with alternative tensor (multi-dimensional array) regression models.