bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovation in public organizations: do government reforms matter?
Authors: Hijal-Moghrabi Imane , Sabharwal Meghna , Ramanathan Kannan 
Published: September 2020

PurposeThe purpose of this study is to examine the impact of New Public Management (NPM) reforms/practices on innovation in public sector organizations. Although much is written on NPM, the assumption that NPM reforms stimulate organizational innovation has not been empirically tested. The present study is an attempt to bridge this research gap.Design/methodology/approachBuilding on open-systems approach, institutional theory, and innovation research, this study argues that organizational innovation occurs in response to stimuli in the external (environmental factors) and internal environment (organizational factors), considering NPM reforms/practices as a proxy for external or environmental factors. Organizational factors include formal structural complexity, senior management support and job security. The study tests this model using data from a national survey conducted in five states in the US.FindingsThe study provides empirical insights into our understanding of the factors that drive innovation in public sector organizations. The study finds that although environmental factors are as significant as organizational factors in driving innovation in the public sector, senior management support remains the most important predictor of innovation.Originality/valueThis paper fulfils an identified need to study the effect of NPM reforms and practices on innovation in public organizational settings.
Augmenting customer loyalty through customer experience management in the banking industry
Authors: Makudza Forbes 
Published: September 2020

PurposeThe purpose of this paper is to analyse and evaluate the effect of customer experience management (virtual interaction, physical interaction and service interaction) on customer loyalty in the banking industry.Design/methodology/approachThe study followed an explanatory research design to sample 384 respondents. Stepwise regression analysis was used to validate the relevance of the study model.FindingsThe results indicated that there is a positive association between customer experience management and customer loyalty. The dimensions of customer experience management, namely virtual interaction, physical interaction and service interaction, were also found to be statistically significant in explaining customer loyalty behaviour.Practical implicationsThe study practically influences the way banks and other financial institutions gain competitive advantage through managing the experiences of customers in a volatile business environment. At a time when banks are no longer the only providers of financial services, the study offers a road map to reduce portfolio purchasing and switching behaviour through enhanced experience management at all customer touch points.Originality/valueThe study presents an augmented model of customer experience management which is linked to consumer loyalty.
Ethos at stake: roads to success among Chinese small businesses in Milan, Italy
Authors: Palombaro Ottavio 
Published: September 2020

Purpose
This paper aims to check the presence of such relationship in the field. Certain values are at stake for the success of economic behavior. Since the genesis of modern capitalism, a set of beliefs proper of Calvinism (mainly Predestination but also Beruf, inner-worldly asceticism, role of Sects […] ) was said by Max Weber to cause an anxiety about salvation and generate a propensity to economic success as a sign of election. The author argues on the contrary that the Calvinist belief in the Perpetual Assurance of Salvation might cause a sense of self-efficacy able to favor economic success. To observe this in action today, it is crucial to consider the evolution that the Protestant ethic went through migrating first in North America and, finally, through the Protestant revival of China. Wenzhou is called “Jerusalem of China” for its large Protestant community that is also strongly involved in business. Some scholar already pointed out the presence among those entrepreneurs of this Protestant ethic (Yi Xiang, Boss-Christian […]).

Design/methodology/approach
The data presented in this comparative qualitative study pertain to ethnographic observations, job-shadowing and interviews done among Chinese Christian and non-Christian entrepreneurs from Wenzhou living in Milan, Italy.

Findings
The results show, with some adjustments, the presence of a Chinese version of the Protestant ethic overlapping with several values proper to the Chinese context (Confucianism, lineage, social network). The extension of the study to other cases must be done with caution considering the non-causal justificatory role of the belief.

Originality/value
Successful entrepreneurship involves specific social, cultural and even religious aspects that move beyond mere business strategies.
Brand equity and customer satisfaction: a comparative analysis of international and domestic tourists in Vietnam
Authors: Tran Phuong Kim Thi , Nguyen Vien Ky , Tran Vinh Trung 
Published: September 2020

Purpose
This paper aims to examine the relationships between brand equity, customer satisfaction and cultural distance for a tourism destination. The mediating role of customer satisfaction and the moderating effect of cultural distance in these relationships are assessed.

Design/methodology/approach
The direct–indirect–moderating relationships were assessed by applying covariance-based SEM (CB-SEM), mediating and multi-group analysis. A paper survey was used to collect data from 618 tourists (domestic and international tourists) visiting a destination in Vietnam.

Findings
The findings support direct positive links between the dimensions of brand equity and customer satisfaction, except for the effect of destination brand awareness on destination brand loyalty. This work further demonstrates the mediating effect of customer satisfaction on the indirect relationships between the dimensions of brand equity. Cultural distance was found to moderate the connections between the research concepts.

Research limitations/implications
Future research should explore the model’s relationships based on comparisons in different destinations, to better understand the impact of cultural factors.

Originality/value
This study identifies specific factors to increase branding efficiency by developing and testing the relationship between brand equity and customer satisfaction. Using moderating variables through the lens of cultural distance, it proposes a mediated model. This work contributes to practice by informing destination managers on how to improve brand equity and satisfaction based on the cultural characteristics of international and domestic visitors.
Analysis of the current development of community centers in Jeddah city
Authors: Naji Ammar A. , Almaimani Ayad , Rahaman Khan Rubayet 
Published: September 2020

Purpose
The Kingdom of Saudi Arabia (KSA) has been experiencing extensive development in the fields of architecture and planning in recent decades, which has included developing community centers in neighborhoods. These community centers have significant impacts on the social, cultural, recreational and economic lives of the inhabitants. The study has looked into the concept of modeled and non-modeled community centers among 114 neighborhoods. Moreover, the study aims to suggest that decision-makers should make efficient decisions to uphold amenities through the centers at the neighborhood level after considering the evaluation techniques included in this paper to ensure a sustainable urbanization.

Design/methodology/approach
The authors collected both qualitative and quantitative information through structured and un-structured interviews in the city of Jeddah. Afterward, the authors evaluated the centers with a summarized grading point based on qualitative judgments. Note that the online questionnaire survey was prepared to distribute in approximately 100 neighborhoods. However, 71 neighborhoods took part in the survey, with a total number of 402 responses. Moreover, the authors made a subjective evaluation of the studied neighborhoods to understand the quality of services offered by the community centers.

Findings
The obtained results reveal that the community centers in the city of Jeddah are playing important roles for socialization, allowing younger people to interact in a positive way, providing services to the communities and supporting volunteer work in and around the neighborhoods. Consequently, the research paper emphasizes the future needs of these important social infrastructures as part of a neighborhood design tool in the context of Jeddah city, KSA.

Originality/value
This research attempts to document the need for community centers in the city of Jeddah. Consequently, the study evaluates 26 different community centers to understand whether the improvements are required for supporting community activities. Indeed, few research works have made an effort to study community centers’ role in urban life in a unique geographic context. Through this research project, the authors have highlighted the implications of community centers in urban life in the city of Jeddah.
Towards sustainable commercial buildings: an analysis of operation and maintenance (O&M) costs in Sri Lanka
Authors: Weerasinghe Achini Shanika , Ramachandra Thanuja , Rotimi James O. B. 
Published: September 2020

PurposeRising energy costs and increasing environmental concerns are catalysts for introducing sustainable design features in buildings. Incorporating sustainable design features in commercial buildings cannot be overstated because it could confer benefits to the investor (owners) and occupants. This study aims to develop a model that could aid in the prediction of operation and maintenance (O&M) costs from the knowledge of building-design variables. There is little evidence that design variables influence the O&M costs of buildings. Therefore, this study investigates the relationship between design variables and O&M costs in commercial buildings with the intent of developing a cost model for estimating O&M costs at the early design phase.Design/methodology/approachThe study was approached quantitatively using a survey strategy. Data for the study were obtained from 30 randomly selected commercial buildings in the CBD in Colombo, Sri Lanka. Pareto's 80/20 rule, correlation and regression analysis were performed on the data to prove the statistical relationships between the buildings' O&M costs and their design variables.FindingsThe study found that 12 significant O&M costs elements contribute to about 82% of total O&M costs. Repairs and decoration had a strong correlation with building shape. Furthermore, the regression analysis found that O&M costs values were primarily dependent on the building size (the gross floor area and height of the buildings). The gross floor area and height handled over 73% of the variance in the O&M costs of commercial buildings in Sri Lanka.Originality/valueThese findings are a useful insight into the principles for design economies that could contribute to more sustainable commercial buildings.
Can risk prediction models help us individualise stillbirth prevention? A systematic review and critical appraisal of published risk models
Authors: Townsend R , Manji A , Allotey J , Heazell AEP , Jorgensen L , Magee LA , Mol BW , Snell KIE , Riley RD , Sandall J , Smith GCS , Patel M , Thilaganathan B , von Dadelszen P , Thangaratinam S , Khalil A 
Published: September 2020

BackgroundStillbirth prevention is an international priority – risk prediction models could individualise care and reduce unnecessary intervention, but their use requires evaluation.ObjectivesTo identify risk prediction models for stillbirth, and assess their potential accuracy and clinical benefit in practice.Search strategyMEDLINE, Embase, DH‐DATA and AMED databases were searched from inception to June 2019 using terms relevant to stillbirth, perinatal mortality and prediction models. The search was compliant with Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guidelines.Selection criteriaStudies developing and/or validating prediction models for risk of stillbirth developed for application during pregnancy.Data collection and analysisStudy screening and data extraction were conducted in duplicate, using the CHARMS checklist. Risk of bias was appraised using the PROBAST tool.ResultsThe search identified 2751 citations. Fourteen studies reporting development of 69 models were included. Variables consistently included were: ethnicity, body mass index, uterine artery Doppler, pregnancy‐associated plasma protein and placental growth factor. For almost all models there were significant concerns about risk of bias. Apparent model performance (i.e. in the development dataset) was highest in models developed for use later in pregnancy and including maternal characteristics, and ultrasound and biochemical variables, but few were internally validated and none were externally validated.ConclusionsAlmost all models identified were at high risk of bias. There are first‐trimester models of possible clinical benefit in early risk stratification; these require validation and clinical evaluation. There were few later pregnancy models but, if validated, these could be most relevant to individualised discussions around timing of birth.Tweetable abstractPrediction models using maternal factors, blood tests and ultrasound could individualise stillbirth prevention, but existing models are at high risk of bias.
High infiltration of CD20+ B lymphocytes in extranodal natural killer/T‐cell lymphoma is associated with better prognosis
Authors: Chen Min‐Min , Zeng Guo‐Peng , Li Jing , Fu Jun‐Hong , Long Ya‐Yi , Pan Jie‐Ying , Wei Lin‐Zhi , Guan Jie‐Ying , Lin Ying‐Xi , You Hua , Si Cheng , Li Wen‐Xing , Liang Yi‐Jun , Liu Da‐Hai , Liu Fang , Liu Fang 
Published: September 2020

AbstractImmune cells have an uncertain function during the progression of extranodal natural killer/T‐cell lymphoma (ENKTL). The present study determined the distribution, phenotype, and clinical significance of B lymphocytes in ENKTL. Immunohistochemistry indicated high infiltration of CD20+ B lymphocytes in the tumour tissues of 40% of the patients, and that a high infiltration correlated with better overall survival. Moreover, B lymphocytes had an active mature phenotype in situ and suppressed the proliferation of ENKTL cells in vitro. These results suggest that tumour infiltration of CD20+ B lymphocytes may be a new prognostic indicator for patients with ENKTL.
A phase 2, open‐label study of single‐dose dupilumab in children aged 6 months to <6 years with severe uncontrolled atopic dermatitis: pharmacokinetics, safety and efficacy
Authors: Paller A.S. , Siegfried E.C. , Simpson E.L. , Cork M.J. , Lockshin B. , Kosloski M.P. , Kamal M.A. , Davis J.D. , Sun X. , Pirozzi G. , Graham N.M.H. , Gadkari A. , Eckert L. , Ruddy M. , Bansal A. 
Published: September 2020

AbstractBackgroundDupilumab has demonstrated efficacy and acceptable safety in adults and children (aged 6–17 years) with moderate‐to‐severe atopic dermatitis (AD), but effective systemic therapy with a favorable risk–benefit profile in younger children remains a significant unmet need.ObjectivesTo determine the pharmacokinetics, safety and efficacy of single‐dose dupilumab in children with severe AD aged ≥6 months to <6 years.MethodsThis open‐label, multicenter, phase 2, sequential, two‐age cohort, two‐dose level study (LIBERTY AD PRE‐SCHOOL; NCT03346434) included an initial cohort of older children aged ≥2 to <6 years, followed by a younger cohort aged ≥6 months to <2 years. Pharmacokinetic sampling, safety monitoring and efficacy assessments were performed during the 4‐week period after a single subcutaneous injection of dupilumab, in two sequential dosing groups (3 mg/kg, then 6 mg/kg). The use of standardized, low‐to‐medium potency topical corticosteroids was allowed.ResultsForty patients were enrolled (20/age cohort, 10/dose level within a cohort) between December 20, 2017 and July 22, 2019. Within each age cohort, pharmacokinetic exposures after a single injection of dupilumab increased in a greater than dose‐proportional manner. At week 3, treatment with 3 and 6 mg/kg dupilumab reduced scores of mean Eczema Area and Severity Index by −44.6% and −49.7% (older cohort) and −42.7% and −38.8% (younger cohort), and mean Peak Pruritus NRS scores by −22.9% and −44.7% (older cohort) and −11.1% and −18.2% (younger cohort), respectively. At week 4, improvements in most efficacy outcomes diminished in both age groups, particularly with the lower dose. The safety profile was comparable to that seen in adults, adolescents and children.ConclusionsSingle‐dose dupilumab was generally well tolerated and substantially reduced clinical signs/symptoms of AD. Slightly better responses were seen in older than younger children. The pharmacokinetics of dupilumab were non‐linear, consistent with previous studies in adults and adolescents.
Signs of early cellular dysfunction in multiple system atrophy
Authors: Herrera‐Vaquero M. , Heras‐Garvin A. , Krismer F. , Deleanu R. , Boesch S. , Wenning G. K. , Stefanova N. 
Published: September 2020

AimsMultiple system atrophy (MSA) is a fatal neurodegenerative disease that belongs to the family of α‐synucleinopathies. At post mortem examination, intracellular inclusions of misfolded α‐synuclein are found in neurons and oligodendrocytes and are considered to play a significant role in the pathogenesis. However, the early steps of the disease process are unknown and difficult to study in tissue derived from end‐stage disease.MethodsInduced pluripotent stem cells (iPSCs) were generated from patients’ and control skin fibroblasts and differentiated into NCAM‐positive neural progenitor cells (NPCs). The mitochondrial morphology and function were assessed by immunocytochemistry and high resolution respirometry. The ability to cope with exogenous oxidative stress was tested by exposure to different doses of luperox. The expression of α‐synuclein was studied by immunocytochemistry.ResultsWe identified increased tubulation of mitochondria with preserved respiration profile in MSA‐derived NPCs. Exposure of these cells to exogenous oxidative stress even at low doses, triggered an excessive generation of reactive oxygen species (ROS) and cleavage of caspase‐3. MSA‐derived NPCs did not present changed levels of SNCA gene expression nor intracellular aggregates of α‐synuclein. However, we identified disease‐related translocation of α‐synuclein to the nucleus.ConclusionsOur results show early cellular dysfunction in MSA‐derived NPCs. We identified changes in the redox homeostasis which are functionally compensated at baseline but cause increased susceptibility to exogenous oxidative stress. In addition, nuclear translocation of α‐synuclein in MSA‐derived NPCs supports an early cellular stress response which may precede the neurodegenerative process in this disorder.
The plant protein NbP3IP directs degradation of Rice stripe virus p3 silencing suppressor protein to limit virus infection through interaction with the autophagy‐related protein NbATG8
Authors: Jiang Liangliang , Lu Yuwen , Zheng Xiyin , Yang Xue , Chen Ying , Zhang Tianhao , Zhao Xing , Wang Shu , Zhao Xia , Song Xijiao , Zhang Xiangxiang , Peng Jiejun , Zheng Hongying , Lin Lin , MacFarlane Stuart , Liu Yule , Chen Jianping , Yan Fei 
Published: September 2020

Summary

In plants, autophagy is involved in responses to viral infection. However, the role of host factors in mediating autophagy to suppress viruses is poorly understood.

A previously uncharacterized plant protein, NbP3IP, was shown to interact with p3, an RNA‐silencing suppressor protein encoded by Rice stripe virus (RSV), a negative‐strand RNA virus. The potential roles of NbP3IP in RSV infection were examined.

NbP3IP degraded p3 through the autophagy pathway, thereby affecting the silencing suppression activity of p3. Transgenic overexpression of NbP3IP conferred resistance to RSV infection in Nicotiana benthamiana. RSV infection was promoted in ATG5‐ or ATG7‐silenced plants and was inhibited in GAPC‐silenced plants where autophagy was activated, confirming the role of autophagy in suppressing RSV infection. NbP3IP interacted with NbATG8f, indicating a potential selective autophagosomal cargo receptor role for P3IP. Additionally, the rice NbP3IP homolog (OsP3IP) also mediated p3 degradation and interacted with OsATG8b and p3.

Through identification of the involvement of P3IP in the autophagy‐mediated degradation of RSV p3, we reveal a new mechanism to antagonize the infection of RSV, and thereby provide the first evidence that autophagy can play an antiviral role against negative‐strand RNA viruses.
The Mechanical Efficiency of Harmonic Drives: A Simplified Model
Authors: Gravagno Federico , Mucino Victor H. , Pennestrì Ettore 
Published: September 2020

Abstract
Harmonic drives are widely used devices in robotic and space applications. As for any device transmitting motion, its mechanical efficiency is one of the main concerns for the designer. In this paper, it is proposed a new model to estimate this significant feature. The proposed approach makes use of the kinematic correspondence between the harmonic drive and an epicyclic gear train. Although the authors introduced simple approximations to describe the complex tribological phenomena during harmonic drive teeth meshing, the numerical results match the trend of experimental evidence. In particular, assuming the harmonic drive working at the rated torque, the plots of the mechanical efficiency versus different parameters such as temperature and angular speed have been simulated.
Theoretical and Experimental Research on Designed Bursting Pressure of Ultrahigh Pressure Rupture Disk
Authors: Yang Chao , Hui Hu , Song Xinyi , Huang Song 
Published: September 2020

Abstract
Rupture disk safety device plays an important role as the last safety barrier to prevent catastrophic overpressure in chemical vessels. In this article, a burst pressure calculation method of ultrahigh pressure rupture disk is presented based on “Levy–Mises Increment Theory” and “Torque Theory.” Besides, the calculation result is verified reasonable by numerical simulation and experiment. Thus, the calculation formula can be applied in the design of ultrahigh pressure rupture disk.