bluuebunny/crossref_metadata_2025_split huggingface dataset:
Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells
Authors: Nakamura Yuki , Sasaki Tomoyuki , Mochizuki Chihiro , Ishimaru Kayoko , Koizumi Schuichi , Shinmori Hideyuki , Suzuki-Inoue Katsue , Nakao Atsuhito 
Published: November 2019

AbstractVenomous snakebites can induce local tissue damage, including necrosis of soft tissues, haemorrhage, blistering and local swelling associated with plasma extravasation, which can lead to lethal complications such as hypovolemic shock. However, the details of the underlying mechanisms remain unknown. In this study, we showed that intradermal treatment of mice with venom rhodocytin from the Malayan viper Calloselasma rhodostoma induced plasma extravasation, dependent on C-type lectin-like receptor 2 (CLEC-2) on platelets. Rhodocytin-induced plasma extravasation also relied on mast cells and histamine. In vitro co-culture of rhodocytin-activated platelets with mast cells induced histamine release from mast cells in an ATP/P2X7-dependent manner. Consistent with this, blockade or deficiency of P2X7 in mast cells suppressed rhodocytin-induced plasma extravasation in the skin. Together, these findings indicate that rhodocytin induces plasma extravasation by triggering platelet activation via CLEC-2, followed by activation of mast cells and histamine release via the ATP/P2X7 pathway. These results reveal a previously unrecognized mechanism by which snake venom increases vascular permeability via complex venom toxin–mediated interactions between platelets and mast cells.
Exotic magnetic behaviour and evidence of cluster glass and Griffiths like phase in Heusler alloys Fe2-xMnxCrAl (0 ≤ x ≤ 1)
Authors: Yadav Kavita , Sharma Mohit K. , Singh Sanjay , Mukherjee K. 
Published: November 2019

AbstractWe present a detailed study of structural, magnetic and thermodynamic properties of a series of Heusler alloys Fe2-xMnxCrAl (x = 0, 0.25, 0.5, 0.75 and 1). Structural investigation of this series is carried out using high resolution synchrotron X-ray diffraction. Results suggest that with increasing Mn concentration, the L21 structure of Fe2CrAl is destabilized. The DC magnetization results show a decrement in paramagnetic (PM) to ferromagnetic (FM) phase transition temperature (TC) with increasing Mn concentration. From the systematic analysis of magnetic memory effect, heat capacity, time dependent magnetization, and DC field dependent AC susceptibility studies it is observed that, Fe2CrAl exhibits cluster glass(CG)-like transition approximately at 3.9 K (Tf2). The alloys, Fe1.75Mn0.25CrAl and Fe1.5Mn0.5CrAl exhibit double CG-like transitions near Tf1 ~ 22 K, Tf2 ~ 4.2 K and Tf1 ~ 30.4 K, Tf2 ~ 9.5 K respectively, however, in Fe1.25Mn0.75CrAl, a single CG-like transition is noted at Tf2 ~ 11.5 K below TC. Interestingly, FeMnCrAl shows the absence of long ranged magnetic ordering and this alloy undergoes three CG-like transitions at ~22 K (Tf*), 16.6 K (Tf1) and 11 K (Tf2). At high temperatures, a detailed analysis of temperature response of inverse DC susceptibility clearly reveals the observation of Griffiths phase (GP) above 300 K (T*) in Fe2CrAl and this phase persists with Mn concentration with a decrement in T*.
Radiation dose and image quality of high-pitch emergency abdominal CT in obese patients using third-generation dual-source CT (DSCT)
Authors: Forbrig Robert , Ingrisch Michael , Stahl Robert , Winter Katharina Stella , Reiser Maximilian , Trumm Christoph G. 
Published: November 2019

AbstractIn this third-generation dual-source CT (DSCT) study, we retrospectively investigated radiation dose and image quality of portal-venous high-pitch emergency CT in 60 patients (28 female, mean age 56 years) with a body mass index (BMI) ≥ 30 kg/m2. Patients were dichotomized in groups A (median BMI 31.5 kg/m2; n = 33) and B (36.8 kg/m2; n = 27). Volumetric CT dose index (CTDIvol), size-specific dose estimate (SSDE), dose length product (DLP) and effective dose (ED) were assessed. Contrast-to-noise ratio (CNR) and dose-independent figure-of-merit (FOM) CNR were calculated. Subjective image quality was assessed using a five-point scale. Mean values of CTDIvol, SSDE as well as normalized DLP and ED were 7.6 ± 1.8 mGy, 8.0 ± 1.8 mGy, 304 ± 74 mGy * cm and 5.2 ± 1.3 mSv for group A, and 12.6 ± 3.7 mGy, 11.0 ± 2.6 mGy, 521 ± 157 mGy * cm and 8.9 ± 2.7 mSv for group B (p < 0.001). CNR of the liver and spleen as well as each calculated FOM CNR were significantly higher in group A (p < 0.001). Subjective image quality was good in both groups. In conclusion, third-generation abdominal high-pitch emergency DSCT yields good image quality in obese patients. Radiation dose increases in patients with a BMI > 36.8 kg/m2.
Language impairment in adults with end-stage liver disease: application of natural language processing towards patient-generated health records
Authors: Dickerson Lindsay K. , Rouhizadeh Masoud , Korotkaya Yelena , Bowring Mary Grace , Massie Allan B. , McAdams-Demarco Mara A. , Segev Dorry L. , Cannon Alicia , Guerrerio Anthony L. , Chen Po-Hung , Philosophe Benjamin N. , Mogul Douglas B. 
Published: November 2019

AbstractEnd-stage liver disease (ESLD) is associated with cognitive impairment ranging from subtle alterations in attention to overt hepatic encephalopathy that resolves after transplant. Natural language processing (NLP) may provide a useful method to assess cognitive status in this population. We identified 81 liver transplant recipients with ESLD (4/2013–2/2018) who sent at least one patient-to-provider electronic message pre-transplant and post-transplant, and matched them 1:1 to “healthy” controls—who had similar disease, but had not been evaluated for liver transplant—by age, gender, race/ethnicity, and liver disease. Messages written by patients pre-transplant and post-transplant and controls was compared across 19 NLP measures using paired Wilcoxon signed-rank tests. While there was no difference overall in word length, patients with Model for End-Stage Liver Disease Score (MELD) ≥ 30 (n = 31) had decreased word length in pre-transplant messages (3.95 [interquartile range (IQR) 3.79, 4.14]) compared to post-transplant (4.13 [3.96, 4.28], p = 0.01) and controls (4.2 [4.0, 4.4], p = 0.01); there was no difference between post-transplant and controls (p = 0.4). Patients with MELD ≥ 30 had fewer 6+ letter words in pre-transplant messages (19.5% [16.4, 25.9] compared to post-transplant (23.4% [20.0, 26.7] p = 0.02) and controls (25.0% [19.2, 29.4]; p = 0.01). Overall, patients had increased sentence length pre-transplant (12.0 [9.8, 13.7]) compared to post-transplant (11.0 [9.2, 13.3]; p = 0.046); the same was seen for MELD ≥ 30 (12.3 [9.8, 13.7] pre-transplant vs. 10.8 [9.6, 13.0] post-transplant; p = 0.050). Application of NLP to patient-generated messages identified language differences—longer sentences with shorter words—that resolved after transplant. NLP may provide opportunities to detect cognitive impairment in ESLD.
Anti-cancer activities of metal-based complexes by regulating the VEGF/VEGFR2 signaling pathway and apoptosis-related factors Bcl-2, Bax, and caspase-9 to inhibit angiogenesis and induce apoptosis
Authors: Qin Xiu-Ying , Wang Ya-Nan , Liu Han-Fu , Luo Zhao-Hui , Zhang Pei-Lu , Li-Fang Huang , Liu Mei-Rong 
Published: November 2019

AbstractThree novel single crystals of the metal-based complexes Cu-1, Cu-2, and Co-1 were obtained and characterized. Compared with Cu-2 and Co-1, Cu-1 showed remarkable activities of anti-cervical cancer, anti-cisplatin-resistant non-small cell lung cancer and anti-angiogenesis by downregulating the expressions of important proteins in the VEGF/VEGFR2 signaling pathway to inhibit angiogenesis and cancer cell proliferation, induce apoptosis, and suppress migration and metastasis. Moreover, Cu-1 dramatically inhibited the expression of the anti-apoptotic protein Bcl-2 and up-regulated the expressions of the proapoptotic proteins caspase-9 and Bax to induce the apoptosis of tumor cells, simultaneously decreasing the density of endothelial cells to inhibit tumor angiogenesis in cisplatin-resistant tumors.
The association between IL-17 gene variants and risk of colorectal cancer in a Chinese population: A case–control study
Authors: Feng Haiyang , Ying Rongbiao , Chai Tengjiao , Chen Hailang , Ju Haixing 
Published: November 2019

Abstract
Interleukin (IL)-17 have been reported to be associated with the pathogenesis of colorectal cancer (CRC). Few studies investigated the association between IL-17 gene polymorphisms and risk of CRC with inconsistent findings. Thus, we recruited 352 CRC cases and 433 controls in a Chinese population and their genotyping was done using polymerase chain reaction-restriction fragment length polymorphism method. Our data showed that IL-17A rs2275913 polymorphism was associated with the increased risk of CRC, while no association was observed for IL-17F rs763780 polymorphism. Stratified analyses revealed that the significant association was also obtained in the females, smokers, drinkers and age ≥ 60 years groups for rs2275913 polymorphism. Moreover, the CC and/or GC genotype of rs2275913 polymorphism were correlated with TNM stage and lymph node metastasis. No association was shown between IL-17F rs763780 polymorphism and clinical characteristics of CRC. In conclusion, our data indicate that IL-17A rs2275913 polymorphism but not IL-17F rs763780 polymorphism contributes to increased risk for CRC patients in this Chinese population.
LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways
Authors: Liu Zhihui , Luo Sukun , Wu Meiqin , Huang Chong , Shi Huifen , Song Xiaojie 
Published: November 2019

Abstract
Cervical cancer (CC) is a prevalent gynecological cancer, and the patients with CC usually suffer from dismal prognosis. Long non-coding RNAs (lncRNAs) are demonstrated to serve as promising biological targets in human cancers. Gastric carcinoma proliferation enhancing transcript 1 (GHET1) has been revealed to function as an oncogene in several cancers, but it has never been investigated in CC. We proposed to examine the biological role of GHET1 in CC and the underlying mechanism and validated the up-regulated expression of GHET1 in CC cell lines. Loss-of-function assays demonstrated that down-regulation of GHET1 inhibited cell growth, migration and epithelial-to-mesenchymal transition (EMT) in CC. Furthermore, we validated that GHET1 down-regulation could inactivate AKT/mTOR and Wnt/β-catenin pathways, and that respective activation of these two pathways abrogated the inhibitive effect of GHET1 knockdown on CC cell growth, migration and EMT. Moreover, we unfolded a preliminary investigation on the modulation of GHET1 on AKT/mTOR and Wnt/β-catenin pathways. We found that GHET1 stabilized E2F6 mRNA through interacting with IGF2BP2, so as to regulate the activity of AKT/mTOR and Wnt/β-catenin pathways. Rescue assays also proved that GHET1 regulated these two pathways and CC cell growth, migration and EMT through E2F6. In conclusion, we revealed that down-regulation of GHET1 suppresses cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways, indicating GHET1 as a promising molecular biomarker for CC treatment improvement.
The Influence of Phonomotor Treatment on Word Retrieval: Insights From Naming Errors
Authors: Minkina Irene , Silkes JoAnn P. , Bislick Lauren , Madden Elizabeth Brookshire , Lai Victoria , Pompon Rebecca Hunting , Torrence Janaki , Zimmerman Reva M. , Kendall Diane L. 
Published: November 2019

Purpose
An increasing number of anomia treatment studies have coupled traditional word retrieval accuracy outcome measures with more fine-grained analysis of word retrieval errors to allow for more comprehensive measurement of treatment-induced changes in word retrieval. The aim of this study was to examine changes in picture naming errors after phonomotor treatment.

Method
Twenty-eight individuals with aphasia received 60 hr of phonomotor treatment, an intensive, phoneme-based therapy for anomia. Confrontation naming was assessed pretreatment, immediately posttreatment, and 3 months posttreatment for trained and untrained nouns. Responses were scored for accuracy and coded for error type, and error proportions of each error type (e.g., semantic, phonological, omission) were compared: pre- versus posttreatment and pretreatment versus 3 months posttreatment.

Results
The group of treatment participants improved in whole-word naming accuracy on trained items and maintained their improvement. Treatment effects also generalized to untrained nouns at the maintenance testing phase. Additionally, participants demonstrated a decrease in proportions of omission and description errors on trained items immediately posttreatment.

Conclusions
Along with generalized improved whole-word naming accuracy, results of the error analysis suggest that a global (i.e., both lexical–semantic and phonological) change in lexical knowledge underlies the observed changes in confrontation naming accuracy following phonomotor treatment.
Vom Verschweigen zur späten Anerkennung der Opfer
Authors: Böcker Felix M. 
Published: November 2019

ZUSAMMENFASSUNGAnlässlich der Wanderausstellung der DGPPN über „kranke und behinderte Menschen im Nationalsozialismus“ hat der Verfasser – vorwiegend anhand der eigenen Lektüre – den Versuch unternommen, den Umgang mit der Geschichte der Zwangssterilisierungen und Krankentötungen in den Jahren zwischen 1945 und 2010 nachzuzeichnen. Der Gang durch 7 Dekaden zeigt, dass mit der Dokumentation des Geschehenen unmittelbar nach dem Ende der nationalsozialistischen Diktatur in den Jahren 1945 bis 1948 begonnen wurde, wobei es Hinweise auf eine aktive und systematische Unterdrückung der Publikation der Befunde durch die ehemaligen Täter gibt; erst nach der Enquête des Deutschen Bundestages zur Lage der Psychiatrie und mit fast 4 Jahrzehnten Verspätung ergaben immer mehr lokale und regionale Berichte ein allmählich dichter werdendes Gesamtbild. Die „Aufarbeitung der Aufarbeitung“ ist eine Zukunftsaufgabe, mit der erst kürzlich begonnen wurde.
Früherkennung der Alzheimer-Demenz mit neuropsychologischen Methoden
Authors: Marczak Agnies 
Published: November 2019

ZUSAMMENFASSUNGDie Früherkennung der Gedächtnisprobleme erfolgt vorwiegend mithilfe von neuropsychologischen Instrumenten. Da es noch kein wirksames Mittel zur Heilung der Erkrankung gibt, ist die Hemmschwelle und Angst vor der Diagnose hoch. Deswegen wird diese meist erst dann gestellt, wenn die Gedächtnisprobleme gravierend sind. Dieser Artikel soll eine kurze Übersicht über die oft verwendeten Instrumente, die Probleme der Testung und deren mögliche Lösungen vorstellen.
Empowerment und Stigma als Mediatorvariablen zwischen Krankheitsschwere und Lebensqualität bei Patienten mit einer affektiven Erkrankung
Authors: Panzirsch Maria , Frasch Karel , Kilian Reinhold 
Published: November 2019

Zusammenfassung
Ziel Die Analyse der Effekte von Empowerment und Stigma auf den Zusammenhang von Depressivität und subjektiver Lebensqualität bei Patienten mit affektiven Erkrankungen.
Methodik Messung von Depressivität (BDI-II), internalisiertem und wahrgenommenem Stigma (ISMI; PDDQ), Empowerment (EPAS) und subjektiver Lebensqualität (WHOQOL-BREF) bei 37 Patienten mit affektiver Erkrankung.
Ergebnisse Empowerment und in geringem Maße Stigmatisierung erwiesen sich als vermittelnde Variablen zwischen Depressivität und Lebensqualität.
Schlussfolgerung Empowerment hat einen bedeutenden Einfluss als Mediator zwischen Depressivität und Lebensqualität.
Urine Proteomics Profiling and Functional Characterization of Knee
Osteoarthritis Using iTRAQ Technology
Authors: Xiao Ke , Yu Lingjia , Zhu Lisi , Wu Zhihong , Weng Xisheng , Qiu Guixing 
Published: November 2019

AbstractOsteoarthritis (OA) is a degenerative chronic disease affecting the whole joint
structures. With the increment in life expectancy and aging population, OA has
become one of the largest socioeconomic burdens, associated with pain and loss
of joint function. However, early laboratory tests of OA are still lacking.
Therefore, new diagnostic tests for this disease are urgently needed. In this
study, to gain an insight into the pathogenesis and the potential biomarkers of
OA, we implemented a comparative urine proteomics study on OA patients and
health people using iTRAQ-based mass spectrometry technology. Western blotting
was used to validate the relative changes in urine protein levels for four of
the identified proteins. We constructed a comprehensive urine proteome profile
of the OA patients and identified 102 proteins differently changed in abundance.
Forty-six proteins were upregulated and 56 proteins were significantly
downregulated in OA patients. Furthermore, the proteins, COL-4, MMP9,
adiponectin, and BBOX1 were validated through Western blots, which can serve as
valuable candidate biomarkers and help to illustrate the pathogenesis of OA.
These findings may provide clues for promising biomarkers for the early
diagnosis and also offer a theoretical basis for the early treatment of OA.
Unerwünschte Ereignisse durch unsachgemäß durchgeführte Psychotherapie
Authors: Gawlytta Romina , Schwartze Dominique , Schönherr Désirée , Schleu Andrea , Strauß Bernhard 
Published: November 2019

Zusammenfassung
Ziel der Studie In einer Pilotstudie wurde das neu entwickelte Inventar zur Erfassung von Kunstfehlern und Kunstfehlerfolgen in der Psychotherapie (IKKIP) erstmals eingesetzt, um die Häufigkeit therapeutischen Fehlverhaltens aus Patientensicht zu erfassen, die resultierende Belastung zu erheben und Prädiktoren zu identifizieren.
Methodik Ausgewertet wurden Daten von N = 165 Patienten mit Psychotherapieerfahrung, die an der Online-Befragung teilnahmen.
Ergebnisse Die Patienten berichteten im Mittel M = 16,21 Ereignisse, die im Sinne von Kunstfehlern interpretierbar sind, und zu einer Belastung mittelmäßiger Schwere führten. Während Ereignisse der Kategorie „Mangelhafte Diagnostik/Technikanwendung“ am häufigsten berichtet wurden, gingen sexuelle Grenzverletzungen mit dem höchsten Belastungsgrad einher.
Schlussfolgerung Die Ergebnisse belegen die Notwendigkeit einer differenzierten und systematischen Erfassung von Kunstfehlern und deren Folgen. Das IKKIP scheint dabei vor allem für den Forschungsbereich geeignet.
The Role of Magnetic Resonance Imaging of the Temporomandibular Joint to Investigate Tinnitus in Adults with Temporomandibular Joint Disorder: A Comparative Study
Authors: Lavinsky Danielle , Lavinsky Joel , Setogutti Enio Tadashi , Rehm Daniela Disconzi Seitenfus , Lavinsky Luiz 
Published: November 2019

Abstract
Introduction The prevalence of tinnitus is higher in individuals with temporomandibular joint disorder (TMD) than in the general population. Magnetic resonance imaging (MRI) of the temporomandibular joint (TMJ) is the method of choice for investigation, and it has been hypothesized that specific MRI findings might be observed in TMD with comorbid tinnitus.
Objective To comparatively describe MRI findings in patients with TMD with and without tinnitus, identifying the most common TMJ alterations and determining whether a correlation exists between severity of TMD and tinnitus.
Methods A cross-sectional study of 53 adult patients with bilateral or unilateral TMD (30 with and 23 without tinnitus). The association between tinnitus and morphological aspects of TMD (changes in condylar morphology, articular eminence morphology, and disc morphology), disc displacement (with/without reduction), condylar translation, and intra-articular effusion was analyzed on MRI images.
Results The mean patient age was 46.12 ± 16.1 years. Disc displacement was the most common finding in both groups (24 patients with tinnitus versus 15 without; p = 0.043). Only the frequency of disc displacement with reduction was significantly different between groups.
Conclusion Additional imaging techniques should be explored to detect specific aspects of the relationship between tinnitus and TMD.
Lateral-Expansion Pharyngoplasty: Combined Technique for the Treatment of Obstructive Sleep Apnea Syndrome
Authors: Pinto José Antonio , Godoy Luciana Balester Mello de , Nunes Heloisa dos Santos Sobreira , Abdo Kelly Elia , Jahic Gabriella Spinola , Cavallini André Freitas , Freitas Gabriel Santos , Ribeiro Davi Knoll , Duarte Caue 
Published: November 2019

Abstract
Introduction Obstructive sleep apnea syndrome (OSAS) is a multifactorial disease characterized by episodes of partial or complete collapse during sleep of different regions of the upper airway. Surgery for OSAS evolved with the introduction of different techniques, considering new surgical concept of reconstruction of the upper airway.
Objective To retrospectively evaluate the effectiveness of a new approach aimed at reducing pharyngeal collapse by combining two surgical techniques: lateral and expansion pharyngoplasty.
Methods We reviewed the medical records of 38 patients with OSAS undergoing lateral/expansion pharyngoplasty from January 2012 to December 2016. The following data were collected: patient age, gender, and pre- and postoperative body mass index (BMI), Epworth sleepiness scale (ESS) scores, snoring visual analogue scale (VAS) scores, and polysomnography (PSG) results.
Results The PSG results showed a significant reduction in the apnea/hypopnea index (AHI) from 22.4 ± 27.3 events/h preoperatively to 13.6 ± 17.9 events/h postoperatively (p = 0.009), with postoperative AHI reduction greater than 50% in 63.2% of the patients. There was also a significant reduction in the microarousal index (19.5 ± 22.6 vs 11.0 ± 13.4 events/h; p = 0.001) and in the minimum oxygen saturation (82.6 ± 10.3 vs 86.9 ± 11.1; p = 0.007).
Conclusions Lateral-expansion pharyngoplasty represents a new surgical strategy for the treatment of OSAS in patients with palatal collapse by combining two different techniques: lateral and expansion pharyngoplasty. The two techniques, performed as a one-stage procedure, led to improvements in excessive daytime sleepiness, snoring, and PSG respiratory parameters by acting on lateral and retropalatal collapse, producing favorable results with good applicability in otolaryngology clinical practice.
Mismatch Negativity Elicited by Verbal and Nonverbal Stimuli: Comparison with Potential N1
Authors: Brückmann Mirtes , Garcia Michele Vargas 
Published: November 2019

Abstract
Introduction Mismatch negativity (MMN) is a long latency auditory evoked potential, represented by a negative wave, generated after the potential N1 and visualized in a resulting wave.
Objective To identify the time of occurrence of MMN after N1, elicited with verbal and nonverbal stimuli.
Methods Ninety individuals aged between 18 and 56 years old participated in the study, 39 of whom were male and 51 female, with normal auditory thresholds, at least 8 years of schooling, and who did not present auditory processing complaints. All of them underwent audiologic anamnesis, visual inspection of external auditory meatus, pure tone audiometry, speech audiometry, acoustic immittance measures and the dichotic sentence identification test as a screening for alterations in auditory processing, a requirement to participate in the sample. The MMN was applied with two different stimuli, with these being da/ta (verbal) and 750 Hz and 1,000 Hz (nonverbal).
Results There was a statistically significant difference between the latency values of the N1 potential and the MMN with the two stimuli, as well as between the MMN with verbal and nonverbal stimuli, and the latency of the MMN elicited with da/ta being greater than that elicited with 750 Hz and 1,000 Hz, which facilitated its visualization.
Conclusion The time of occurrence of MMN after the N1 elicited with verbal stimuli was 100.4 ms and with nonverbal stimuli 85.5 ms. Thus, the marking of the MMN with verbal stimuli proved to be more distant from N1 compared with the nonverbal stimuli.