bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Short-term Effect of Graded Motor Imagery on the Affective Components of Pain in Subjects with Chronic Shoulder Pain Syndrome: Open-Label Single-Arm Prospective Study
Authors: Araya-Quintanilla Felipe , Gutiérrez-Espinoza Héctor , Jesús Muñoz-Yanez María , Rubio-Oyarzún David , Cavero-Redondo Iván , Martínez-Vizcaino Vicente , Álvarez-Bueno Celia 
Published: December 2019

Abstract

Objective
To determine the short-term effect of graded motor imagery (GMI) on the affective components of pain and range of motion in subjects with chronic shoulder pain syndrome.

Design
Open-label single-arm prospective study.

Setting
The Physical Therapy Laboratory, Universidad de las Americas.

Subjects
One hundred seven patients with chronic shoulder pain syndrome.

Methods
The subjects received a six-week GMI program based on laterality training, imagined movements, and mirror therapy. We assessed pain intensity using a visual analog scale (VAS), fear of movement was assessed using the Tampa Scale of Kinesiophobia (TSK), and catastrophizing was assessed using the Pain Catastrophizing Scale (PCS). The patient’s flexion active range of motion (AROM) was also recorded.

Results
At the end of treatment, the VAS showed a decrease of 4.2 cm (P &lt; 0.001, Cohen’s d = 3.3), TSK showed a decrease of 17.0 points (P &lt; 0.001, Cohen’s d = 2.8), catastrophizing showed a decrease of 19.2 points (P &lt; 0.001, Cohen’s d = 3.2), and shoulder flexion AROM showed an increment of 30.3º (P &lt; 0.000, Cohen’s d = 1.6).

Conclusions
We conclude that a short-term GMI program improves the affective components of pain and shoulder flexion AROM in patients with chronic shoulder pain syndrome.
Reducing the Pain Behind Opioid Prescribing in Primary Care
Authors: González José Luis , Prabhakar Radhika , Marks Jennifer , Vigen Cheryl L P , Shukla Jagruti , Bannister Beatrisa 
Published: December 2019

Abstract

Objective
To describe the efficacy of a comprehensive approach aimed at reducing opioid prescribing in an internal medicine resident clinic.

Design
Retrospective observational study.

Setting
Internal medicine primary care resident clinic at a large urban academic medical center.

Subjects
All patients receiving opioid prescriptions from the primary care clinic.

Methods
We reviewed pharmacy dispensing data for two hospital-affiliated pharmacies for resident primary care patients filling opioid prescriptions between July 2016 and July 2018. We instituted a comprehensive set of interventions that included resident education, limiting supervision of encounters for long-term opioid therapy (LTOT) to a fixed set of faculty champions, and providing alternate modalities for pain control. We calculated the change in number of opioid prescriptions dispensed, number of patients receiving opioid prescriptions, morphine milligram equivalents (MMEs) dispensed, and average per-patient daily MMEs dispensed.

Results
We observed an average monthly reduction of 2.44% (P &lt; 0.001) in the number of prescriptions dispensed and a 1.83% (P &lt; 0.001) monthly reduction in the number of patients receiving prescriptions. Over the two-year period, there was a 74.3% reduction in total MMEs prescribed and a 66.5% reduction in the average MMEs prescribed per patient.

Conclusions
Our findings demonstrate a significant reduction in opioid prescribing after implementation of a comprehensive initiative. Although our study was observational in nature, we witnessed a nearly threefold decrease in opioid prescribing compared with national trends. Our results offer important insights for other primary care resident clinics hoping to engender safe prescribing practices and curb high-dose opioid prescribing.
Development and Initial Validation of the Self-Care Practices Scale
Authors: Lee Jacquelyn J , Miller Shari E , Bride Brian E 
Published: December 2019

Abstract
Self-care is regarded as essential for effective social work practice, offsetting occupational stress and promoting well-being and resiliency among practitioners. However, the literature reveals a notable absence of psychometrically sound instruments to measure self-care. The purpose of the present study was to describe the development, refinement, and construct validity of the Self-Care Practices Scale (SCPS). The piloted version of the SCPS is a 38-item instrument designed to measure frequency of engagement in personal and professional self-care practices. Data were collected through mailed surveys from a random sample of master’s-level clinical social workers and members of the National Association of Social Workers (N = 492). Analysis supports the construct validity of an 18-item SCPS with two subscales that demonstrate strong internal validity. The SCPS is useful for social work educators, practitioners, and administrators to ascertain frequency of self-care practice and build a stronger culture of self-care. The role of SCPS in future research is discussed.
Wegbreit: a cautionary tale for trustees, lawyers and wealth owners
Authors: Hunter Chelsea , Gifford James 
Published: December 2019

Abstract
On 8 July 2019, the US Tax Court held that a grantor trust holding offshore life insurance constituted a sham. A review of the facts of the case and the court’s opinion offer a cautionary tale to those planning, maintaining, or benefitting from similar wealth-holding structures. Like most cautionary tales, this one blends a unique factual milieu with tragic decision-making. But, unlike most cautionary tales, this one helps to illustrate some fundamental tax and wealth structure planning points.
International Pediatric Otolaryngology Group (IPOG) Consensus Recommendations: Congenital Cholesteatoma
Authors: Denoyelle Françoise , Simon François , Chang Kay W. , Chan Kenny H. , Cheng Alan G. , Cheng Alan T. , Choo Daniel I. , Daniel Sam J. , Farinetti Anne , Garabedian Erea-Noël , Greinwald John H. , Hoff Stephen R. , Hone Stephen , Licameli Greg R. , Papsin Blake C. , Poe Dennis S. , Pransky Seth , Smith Richard J. H. , Triglia Jean-Michel , Walton Joanna , Zalzal George , Leboulanger Nicolas 
Published: December 2019

Objective:
To provide recommendations to otolaryngologists and allied physicians for the comprehensive management of children who present with signs and symptoms of congenital cholesteatoma.

Methods:
A two-iterative Delphi method questionnaire was used to establish expert recommendations by the members of the International Pediatric Otolaryngology Group, on the preoperative work-up, the perioperative considerations, and follow-up.

Results:
Twenty-two members completed the survey, in 14 tertiary-care center departments representing 5 countries. The main consensual recommendations were: a precise otoscopic description of the quadrants involved, extensive audiological workup (bilateral tonal, vocal audiometry, and BERA), and a CT scan are required. Facial nerve monitoring and a combination of microscope and telescope are recommended for surgical removal. Clinical and audiological follow-up should be pursued yearly for at least 5 years. First MRI follow-up should be done at 18 months postoperatively if the removal violated the matrix. MRI follow-up duration depends on the initial extent of the cholesteatoma.

Conclusion:
The goal of preoperative and follow-up consensus from International Pediatric Otolaryngology Group participants is to help manage infants and children with congenital cholesteatoma. The operative techniques may vary, and experienced surgeons must perform these procedures.
Is chorioamnionitis associated with neurodevelopmental outcomes in preterm infants? A systematic review and meta-analysis following PRISMA
Authors: Xing Lu , Wang Guoyu , Chen Ruiqi , Ren Jianhua , Qian Jiahui , Huang Yan 
Published: December 2019

Abstract

Background:
The relationships between chorioamnionitis (CA) and neurodevelopmental outcomes in preterm infants remain controversial. The meta-analysis aims to evaluate the associations between CA and neurodevelopmental deficits in preterm infants.

Methods:
All studies exploring the associations between CA and neurodevelopmental deficits in preterm infants were retrieved from the following databases: PubMed, Embase, OVID, EBSCO, ProQuest, CDSR, and CENTRAL. The NOS was used to evaluate the quality of the studies, RevMan was adopted to analyze the data.

Results:
Twelve studies involving 4267 preterm infants were included. The ORs across studies was 0.95 (P = .77, I

2
= 51%) for cognitive deficits, 1.09 (P = .44, I

2
= 10%) for psychomotor deficits, 1.21 (P = .08, I

2
= 25%) for language deficits, 2.34 (P = .02, I

2
= 0%) for performance intelligence quotient impairment and 2.81 (P = .03, I

2
= 0%) for verbal intelligence quotient impairment. Subgroup analyses based on the severity of cognitive deficits indicated that CA might be correlated with severe cognitive deficits (P = .01, I

2
= 0%) but not with mild cognitive deficits (P = .40, I

2
= 19%). In terms of the CA category, clinical CA may be related to overall psychomotor deficits (P = .01, I

2
= 25%) and overall language deficits (P < .00001, I

2
= 23%) other than histological CA.

Conclusion:
In preterm infants, CA might be a risk factor for performance and verbal intelligence quotient impairment and severe cognitive deficits, and clinical CA might be a risk factor for overall psychomotor and language deficits.
Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease
Authors: Maehara Takashi , Munemura Ryusuke , Shimizu Mayumi , Kakizoe Noriko , Kaneko Naoki , Murakami Yuka , Masafumi Moriyama , Kiyoshima Tamotsu , Kawano Shintaro , Nakamura Seiji 
Published: December 2019

Abstract

Rationale:
Kimura disease (KD) is a rare, chronic inflammatory disorder characterized by subcutaneous granuloma in the head and neck region, as well as increased eosinophil counts and high serum immunoglobulin E (IgE) levels. Kimura disease is suspected to be an IgE-mediated disease, associated with an allergic response, in which antigen-specific B cells are stimulated to undergo specific IgE class switching with disease-specific CD4+ T (Th) cells help. Thus, exploration of the Th cells in affected tissues with KD is a highly promising field of the investigation. However, there have been no reports with direct evidence to implicate Th cells in affected lesions with KD. Here we quantitatively demonstrate that CD4+ GATA3+ T cells and interleukin (IL)-4+ IgE+ c-kit+ mast cells prominently infiltrate in affected lesion with KD.

Patient concerns:
A 56-year-old Japanese man who exhibited painless swelling in the left parotid region.

Diagnoses:
Diagnosis of KD was made based on characteristic histopathologic findings, in conjunction with peripheral eosinophilia and elevated serum IgE levels.

Interventions:
The patient underwent corticosteroid therapy and had been followed for 2 years.

Outcomes:
We report a rare case of KD of the parotid region in a 56-year-old man, followed by corticosteroid therapy for 2 years. The mass decreased in size and skin itchiness decreased after therapy. He was discharged without any complications. Furthermore, we quantitatively demonstrate the dominance of CD4+ GATA3+ T cells in affected tissues of KD and detect IL-4+ IgE+ c-kit+ mast cells in lesions by multicolor staining approaches.

Lessons:
The findings from this case suggest that peripheral blood eosinophilia might serve as a marker of recurrent disease, long-term follow-up is necessary due to the possibility of recurrent. Interactions among expanded IgE+ B cells, CD4+ GATA3+ T cells, eosinophils, and activated mast cells might play a critical role in the pathogenesis of KD.
Acupotomy for nerve entrapment syndrome
Authors: Shen Yifeng , Li Ting , Cai Tao , Zhong Juan , Guo Jing , Shen Huarui 
Published: December 2019

Abstract

Background:
Acupotomy has been widely used to treat nerve entrapment syndrome. But its efficiency has not been scientifically and methodically evaluated. The aim of this study is to evaluate the efficacy and safety of the acupotomy treatment in patients with nerve entrapment syndrome.

Methods:
Fifteen databases will be searched from inception to Dec 2019. We will include randomized controlled trials (RCTs) assessing acupotomy for nerve entrapment syndrome. All RCTs on acupotomy or related interventions will be included. Study inclusion, data extraction and quality assessment will be performed independently by 2 reviewers. Assessment of risk of bias and data synthesis will be performed using RevMan 5.3 software. Cochrane criteria for risk-of-bias will be used to assess the methodological quality of the trials.

Results:
This study will provide a high-quality synthesis of pain VAS and functional disability or the quality of life, the success treatment rate, the recurrent rate and the complications rate to assess the effectiveness and safety of acupotomy for nerve entrapment syndrome patients.

Conclusion:
This systematic review will provide evidence to judge whether acupotomy is an effective intervention for patients with nerve entrapment syndrome.

PROSPERO registration number:
CRD42018109086.
Modified double-opposing Z-plasty for patients with Veau I cleft palate
Authors: Seo Hyung Joon , Denadai Rafael , Pascasio Dax Carlo Go , Lo Lun-Jou 
Published: December 2019

Abstract
Low fistula rate and a satisfactory speech outcome were previously reported by adopting a modified Furlow palatoplasty using small double-opposing Z-plasty (DOZ). The purposes of this study were to (1) describe the technical standardization of further modification of this small DOZ using the medial incision (MIDOZ) approach for Veau I cleft repair; (2) assess the early postoperative outcomes of a single surgeon's experience using this technique; and (3) evaluate the temporal association of this standardization with the necessity of lateral relaxing incisions.
A prospective study (n = 24) was performed consecutively to non-syndromic patients with Veau I cleft palate who underwent MIDOZ approach. Patients with similar characteristics who underwent small DOZ were included as a retrospective group (n = 25) to control for the potential effect of the standardization of surgical maneuvers (including the hamulus fracture) on the rate of lateral relaxing incisions. Six-month complication rate was collected.
No postoperative complications, such as bleeding, flap necrosis, dehiscence or fistula were observed. The prospective group had a significantly (all P < .05) higher rate of hamulus fractures (n = 48, 100%) and a lower rate of lateral relaxing incisions (n = 1, 2%) than the retrospective group (n = 16, 32%; n = 26, 52%).
This technical standardization for performing palatoplasty using MIDOZ approach provided adequate Veau I cleft palate closure, without fistula formation, and with a low need of lateral relaxing incisions.
High prevalence of sleep disorders and behavioral and psychological symptoms of dementia in late-onset Alzheimer disease
Authors: Zhou Guoyu , Liu Shuangwu , Yu Xiaolin , Zhao Xinjin , Ma Lin , Shan Peiyan 
Published: December 2019

Abstract
Alzheimer disease (AD) is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly. Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors for AD patients. Sleep disorder is one closely-related psychiatric symptom of AD. In this cross-section study, we aimed to investigate the characteristics of sleep status and BPSD among AD patients in Eastern China and to assess the relationship among sleep disorder, BPSD, and cognition.
A total of 176 participants were enrolled in the study, including 84 AD patients and 92 healthy individuals as controls. Mini-mental state examination (MMSE), cooperative study-activities of daily living (ADCS-ADL) and clinical dementia rating (CDR) were used to measure cognition, the competence in basic and instrumental activities of daily living, and severity of dementia, respectively. BPSD were evaluated by neuropsychiatric inventory (NPI). Pittsburgh sleep quality index (PSQI) and Epworth sleepiness scale were designed to assess the sleep status and daytime naps. Spearman correlation analyses were performed to determine the relations between PSQI, MMSE, ADCS-ADL, and NPI scores and CDR.
Sleep disorders occurred in 55.9% of AD patients versus only 15.2% of controls. 89.2% of AD patients had BPSD while only 22.9% of controls did, with apathy (64.2%) the most common among AD patients. Among AD patients, PSQI was negatively correlated with both MMSE (r = −0.600, P < .01) and ADCS-ADL (r = −0.725, P < .01), and was positively correlated with total NPI score (r = 0.608, P < .01). PSQI was closely associated with depression (r = 0.653, P < .01) and apathy (r = 0.604, P < .01).
This study showed that AD patients have a higher prevalence of sleep disorders and BPSD than healthy elderly adults. Sleep disorders affect cognition of AD patients and increase apathy and depression. These results can help investigate new therapeutic targets in AD treatments.
Limited evidence for selection at theFADSlocus in Native American populations
Authors: Mathieson Iain 
Published: December 2019

AbstractTheFADSlocus contains the genesFADS1andFADS2that encode enzymes involved in the synthesis of long-chain polyunsaturated fatty acids (LC-PUFA). This locus appears to have been a repeated target of selection in human evolution, likely because dietary input of LC-PUFA varied over time depending on environment and subsistence strategy. Several recent studies have identified selection at theFADSlocus in Native American populations, interpreted as evidence for adaptation during or subsequent to the passage through Beringia. Here, we show that these signals of selection are confounded by the presence of parallel adaptation–postdating their split from Native Americans–in the European and East Asian populations used in the population branch statistic (PBS) test. This is supported by direct evidence from ancient DNA that one of the putatively selected haplotypes was already common in Northern Eurasia at the time of the separation of Native American ancestors. A more parsimonious explanation for the present-day distribution of the haplotype is that Native Americans retain the ancestral state of Paleolithic Eurasians. Another haplotype at the locus may reflect a secondary selection signal, although its functional impact is unknown.
Dscam homophilic specificity is generated by high ordercis-multimers coupled withtransself-binding of variable Ig1 in Chelicerata
Authors: Zhou Fengyan , Cao Guozheng , Dai Songjun , Li Guo , Li Hao , Ding Zhu , Hou Shouqing , Xu Bingbing , You Wendong , Shi Feng , Yang Xiaofeng , Jin Yongfeng 
Published: December 2019

AbstractBy alternative splicing,Drosophila Down syndrome cell adhesion molecule(Dscam1) encodes tens of thousands of proteins required for establishing neural circuits, while Chelicerata encodes a family of ∼ 100 shortenedDscam(sDscam) isoforms via alternative promoters. We report that Dscam isoforms interact promiscuouslyin cisto generate a vast repertoire of combinatorial homophilic recognition specificities in Chelicerata. Specifically, sDscams formed high ordercis-multimers without isoform specificity involving the membrane-proximal fibronectin type III (FNIII) 1-3 and transmembrane (TM) domains and associated specificallyin transvia antiparallel self-binding of the first variable immunoglobulin (Ig1) domain. We propose that such sDscam combinatorial homophilic specificity is sufficient to provide each neuron with a unique identity for self–non-self discrimination. In many respects, our results amazingly mirror those reported for the structurally unrelated vertebrate protocadherins (Pcdh) rather than for the closely related fly Dscam1. Thus, our findings blur the distinction between the neuronal self-avoidance of invertebrates and vertebrates and provide insight into the basic principles and evolution of metazoan self-avoidance and self–non-self discrimination.
Ectopic overexpression of abiotic stress-induced rice annexin,OsAnn5potentiates tolerance to abiotic stresses
Authors: Boyidi Prasanna , Shalibhadra Trishla Vikas , Botta Halidev Krishna , Yadav Deepanker , Kirti Pulugurtha Bharadwaja 
Published: December 2019

AbstractThe current study on putative rice annexinOsAnn5was tried to know its functional role in the abiotic stress tolerance. For this anin silicoanalysis of its protein sequence and upstream region was carried out. This results in identification of several probable potential sites for post-translational modifications and cis-elements respectively. We have studied the effect ofOsAnn5in the amelioration of abiotic stress tolerance through heterologous expression in transgenic tobacco andE.coli. It is observed thatOsAnn5over expression leads to enhanced tolerance to abiotic stress through efficient scavenging of the ROS and balanced expression of SOD and CAT antioxidant enzymes in both the systems, under stress treatments. Fluorescent signal for transiently expressed EGFP:OsANN5 fusion protein was localized in the peripheral region of the onion epidermal cells under salt stress treatment. Expression analysis ofOsAnn5under ABA synthesis inhibitor, fluridone and salinity stress revealed that OsAnn5 appears to act through an ABA-independent pathway under salt stress and in support to this 35S:OsAnn5transgenics seedlings exhibited less sensitivity to externally applied ABA.
Mechanism ofin vivoactivation of the MutLγ-Exo1 complex for meiotic crossover formation
Authors: Sanchez Aurore , Adam Céline , Rauh Felix , Duroc Yann , Ranjha Lepakshi , Lombard Bérangère , Mu Xiaojing , Loew Damarys , Keeney Scott , Cejka Petr , Guérois Raphaël , Klein Franz , Charbonnier Jean-Baptiste , Borde Valérie 
Published: December 2019

AbstractCrossovers generated during the repair of programmed double-strand breaks (DSBs) during homologous recombination are essential for fertility to allow accurate homolog segregation during the first meiotic division. Most crossovers arise through the cleavage of recombination intermediates by the Mlh1-Mlh3 (MutLγ) endonuclease and an elusive non-catalytic function of Exo1, and require the Polo kinase Cdc5. Here we show in budding yeast that MutLγ forms a constitutive complex with Exo1, and in meiotic cells transiently contacts the Msh4-Msh5 (MutSγ) heterodimer, also required for crossover formation. We further show that MutLγ-Exo1 associates with recombination intermediates once they are committed to the crossover repair pathway, and then Exo1 recruits Cdc5 through a direct interaction that is required for activating MutLγ and crossover formation. Exo1 therefore serves as a non-catalytic matchmaker between Cdc5 and MutLγ. We finally show thatin vivo, MutLγ associates with the vast majority of DSB hotspots, but at a lower frequency near centromeres, consistent with a strategy to reduce at-risk crossover events in these regions. Our data highlight the tight temporal and spatial control of the activity of a constitutive, potentially harmful, nuclease.