bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance evaluation of cryogenically treated wires during wire electric discharge machining of AISI D3 die tool steel under different cutting environments
Authors: Sharma Husandeep , Goyal Khushdeep , Kumar Sunil 
Published: February 2020

PurposeTool steel (AISI D3) is a preferred material for industrial usage. Some of the typical applications of D3 tool steel are blanking and forming dies, forming rolls, press tools and punches bushes. It is used under conditions where high resistance to wear or to abrasion is required and also for resistance to heavy pressure rather than to sudden shock is desirable. It is a high carbon and high chromium steel. Therefore, wire electric discharge machining (WEDM) is used to machine this tool steel. The paper aims to discuss these issues.Design/methodology/approachThe present experimental investigation evaluates the influence of cryogenically treated wires on material removal rate (MRR) and surface roughness (SR) for machining of AISI D3 steel using the WEDM process. Two important process responses MRR and SR have been studied as a function of four different control parameters, namely pulse width, time between two pulses, wire mechanical tension and wire feed rate.FindingsIt was found that pulse width was the most significant parameter which affects the MRR and SR. Better surface finish was obtained with cryogenically treated zinc coated wire than brass wire.Originality/valueThe review of the literature indicates that there is limited published work on the effect of machining parameters in WEDM in cryogenic treated wires. Therefore, in this research work, it was decided to evaluate the effect of cryogenically treated wires on WEDM.
Real‐world evidence of subcutaneous allergoid immunotherapy in house dust mite‐induced allergic rhinitis and asthma
Authors: Jutel Marek , Brüggenjürgen Bernd , Richter Hartmut , Vogelberg Christian 
Published: February 2020

AbstractBackgroundThe objective of this study was to analyze the effectiveness of allergen immunotherapy (AIT) with an allergoid in the treatment of house dust mites (HDM)‐induced allergic rhinitis and/or asthma based on recent real‐life data. The outcomes were measured using asthma incidence and consumption of corresponding medications as the indicator of persisting symptoms.MethodsIn this retrospective cohort analysis of a German longitudinal prescription database, patients who received at least two relevant mite AIT prescriptions in two different successive seasonal cycles were compared with non‐AIT patients who received at least three symptomatic allergic rhinitis (AR) prescriptions in successive mite seasons. Study endpoints included AR progression, asthma progression, asthma occurrence, and therapy adherence. We used multivariate regression analyses to estimate the effects of AIT, adjusting for relevant variables.ResultsThis study included 2350 patients receiving a mite allergoid and 64 740 control patients. After up to 6 years of follow‐up, patients treated with mite allergoid required significantly fewer AR and asthma prescriptions (59.7% vs 10.8%) than the control group, and the probability of asthma development was significantly lower. The adherence of patients receiving allergoid was 63.8% at the end of the second year and 38.6% at the end of the third year.ConclusionsThis real‐world evidence confirms the good efficacy of subcutaneous AIT with HDM mite allergoid in the treatment of allergic rhinitis and/or asthma. Up to 6 years of follow‐up revealed significant effects in allergic rhinitis by measuring the number of AR medications and demonstrating significant reductions in asthma medications.
Why are social enterprises good candidates for social innovation? Looking for personal and institutional drivers of innovation
Authors: Tortia Ermanno C. , Degavre Florence , Poledrini Simone 
Published: February 2020

AbstractThe last few years witnessed theoretical and practical contributions to the field of social innovation and social enterprise. However, analysis of the interplay between these two different realms is still limited. This article aims to fill some gaps in this respect. We deal with historical reconstruction of the concept of Social Enterprise and Social Innovation, and their conceptual premises. We consider the process of creation of social innovation in social enterprises. As members’ motivations, ownership rights and governance rules in social enterprises create a new relational context and new routines, which are germane to the production of social knowledge and deliberation, social innovation can be considered one of the main outcomes of this setting. Social motivations, collective action of a cooperative kind, multi‐stakeholder governance and socialization of resources, and their interplay are singled out as main drivers of innovation. Social innovation is seen as akin to novelty in social interaction, a non‐standardized and non‐standardizable outcome of the operation of this organizational form.
Exploring antecedents and consequences of managerial moral stress
Authors: Ames Justin B. , Gaskin James , Goronson Bradley D. 
Published: February 2020

AbstractThe legitimacy of moral stress as a distinct form of general stress has long been debated in previous research. Moreover, individual‐level antecedents of moral stress are yet to be tested among executives. This study investigates role identity saliency (by calculating the total saliency of roles and competition between roles) as an individual‐level antecedent of managerial moral stress and turnover intent as a consequence of managerial moral stress among high‐level strategic decision makers in organisations. We also analyse the moderating effect of moral attentiveness in these relationships. Survey data were collected from 264 strategic decision makers from small to large U.S.‐based organisations. While controlling for overall stress, results support a moderated model, wherein individuals exhibiting a high level of moral attentiveness also demonstrated a significant positive relationship between work role competition and moral stress and between managerial moral stress and turnover intent. Surprisingly, total role saliency demonstrated a significant negative relationship with managerial moral stress for the same individuals. Overall, the results suggest that managerial moral stress may be a legitimate threat to executive retention, above and beyond general stress, for the individuals who are highly attentive to the moral aspects of their environment.
A 20‐year long term experience of the Italian Diamond‐Blackfan Anaemia Registry: RPS and RPL genes, different faces of the same disease?
Authors: Quarello Paola , Garelli Emanuela , Carando Adriana , Cillario Rebecca , Brusco Alfredo , Giorgio Elisa , Ferrante Daniela , Corti Paola , Zecca Marco , Luciani Matteo , Pierri Filomena , Putti Maria C. , Cantarini Maria E. , Farruggia Piero , Barone Angelica , Cesaro Simone , Russo Giovanna , Fagioli Franca , Dianzani Irma , Ramenghi Ugo ,   the AIEOP working group on Diamond Blackfan Anaemia
Published: February 2020

SummaryDiamond–Blackfan anaemia (DBA) is a rare and heterogeneous disease characterised by hypoplastic anaemia, congenital anomalies and a predisposition for malignancies. The aim of this paper is to report the findings from the Italian DBA Registry, and to discuss the Registry’s future challenges in tackling this disease. Our 20‐year long work allowed the connection of 50 Italian Association of Paediatric Haematology and Oncology (AIEOP) centres and the recruitment of 283 cases. Almost all patients have been characterised at a molecular level (96%, 271/283), finding a causative mutation in 68% (184/271). We confirm the importance of determination of erythrocyte adenosine deaminase activity (eADA) and of ribosomal RNA assay in the diagnostic pipeline and characterisation of a remission state. Patients with mutations in large ribosomal subunit protein (RPL) genes had a significant correlation with the incidence of malformations, higher eADA levels and more severe outcomes, compared to patients with mutations in small ribosomal subunit protein (RPS) genes. Furthermore, as a consequence of our findings, particularly the incidence of malignancies and the high percentage of patients aged >18 years, we stress the importance of collaboration with adult clinicians to guarantee regular multi‐specialist follow‐up. In conclusion, this study highlights the importance of national registries to increase our understanding and improve management of this complex disease.
Ophiopogonin D promotes bone regeneration by stimulating CD31hiEMCNhi vessel formation
Authors: Yang Mi , Li Chang‐Jun , Xiao Ye , Guo Qi , Huang Yan , Su Tian , Luo Xiang‐Hang , Jiang Tie‐Jian 
Published: February 2020

AbstractObjectivesCD31hiEMCNhi vessels (CD31, also known as PECAM1 [platelet and endothelial cell adhesion molecule 1]; EMCN, endomucin), which are strongly positive for CD31 and endomucin, couple angiogenesis and osteogenesis. However, the role of CD31hiEMCNhi vessels in bone regeneration remains unknown. In the present study, we investigated the role of CD31hiEMCNhi vessels in the process of bone regeneration.Materials and MethodsWe used endothelial‐specific Krüppel like factor 3 (Klf3) knockout mice and ophiopogonin D treatment to interfere with CD31hiEMCNhi vessel formation. We constructed a bone regeneration model by surgical ablation of the trabecular bone. Immunofluorescence and micro‐computed tomography (CT) were used to detect CD31hiEMCNhi vessels and bone formation.ResultsCD31hiEMCNhi vessels participate in the process of bone regeneration, such that endothelial‐specific Klf3 knockout mice showed increased CD31hiEMCNhi vessels and osteoprogenitors in the bone regeneration area, and further accelerated bone formation. We also demonstrated that the natural compound, ophiopogonin D, acts as a KLF3 inhibitor to promote vessels formation both in vitro and in vivo. Administration of ophiopogonin D increased the abundance of CD31hiEmcnhi vessels and accelerated bone healing.ConclusionsOur findings confirmed the important role of CD31hiEmcnhi vessels in bone regeneration and provided a new target to treat bone fracture or promote bone regeneration.
An experimental study to evaluate predation threats on two native larval lampreys in the Columbia River Basin, USA
Authors: Arakawa Hiroaki , Lampman Ralph T. 
Published: February 2020

AbstractExperimental predation studies were conducted to evaluate and compare the predation threats of 10 species of native and non‐native fishes on larvae of Pacific Lamprey, Entosphenus tridentatus, and Western Brook Lamprey, Lampetra richardsoni. The relative predatory threats were examined over four sets of binary factors, including the following: (a) short (2‐day) or long (7‐day) duration, (b) presence/absence of fine sediment, (c) live or dead larvae and (d) species of lampreys. Our short‐term results showed a positive correlation with the sizes of predator fishes and consumed lamprey larvae. Also, most predator fishes had a significantly higher propensity to prey on lamprey larvae when sediment was absent. Conversely, this demonstrated the importance of sediment in protecting lamprey larvae from predation. Based on the predatory behaviour for live and dead larvae, predator fishes were classified into four groups using principal component analysis. Predation rates of larvae in sediment by piscivorous predators including Northern Pikeminnow Ptychocheilus oregonensis and Smallmouth Bass Micropterus dolomieu were lower and showed no differences even when the study duration was extended. In contrast, predation rates by benthic predators including White Sturgeon Acipenser transmontanus and Common Carp Cyprinus carpio, increased when we extended the study duration. This suggests that when given longer duration, benthic predators are more adept at consuming larvae within the sediment. These results provide important context for assessing the potential threat of predation on lampreys in streams, which is a key knowledge gap for lampreys.
Introducing patient‐reported outcome in the acute leukemia quality registries in Sweden
Authors: Lennmyr Emma Bergfelt , Karlsson Karin , Abrahamsson Marie , Ebrahim Fereshte , Lübking Anna , Höglund Martin , Juliusson Gunnar , Hallböök Heléne 
Published: February 2020

AbstractObjectivesThe use of patient‐reported outcome (PRO) measured outside clinical trials is not well defined. We report the first analysis of the prospective PRO study within the Swedish acute myeloid leukemia (AML) and the acute lymphoblastic leukemia (ALL) registries.MethodsPRO was requested 6 months after diagnosis. The EORTC Quality of life Questionnaire Core 30‐item, the Patient Health Questionnaire‐8 (PHQ‐8), and questions from a Swedish National Cancer Questionnaire were used.ResultsAn invitation letter was sent to 398 patients; 255 (64%) responded, 60% web‐based, and 40% on paper. The ALL cohort had lower physical, role and social functioning, higher symptom burden, and more financial difficulties compared to the AML cohort. A PHQ‐8 score ≥ 10p, which indicates depression, was reported in 18% of the patients; 33% of these patients reported being prescribed antidepressants. The patients' overall experience of care was satisfying, but more psychological and practical support was desired. There was no difference in survival between patients who reported their PRO and those who did not. Follow‐up at 2 and 4 years is ongoing.ConclusionsPRO collected in a registry‐based setting is feasible, but the selection of time points and questionnaires are delicate in a diverse patient population.
Territory establishment, song learning strategies and survival in song sparrows
Authors: Akçay Çağlar , Campbell S. Elizabeth , Darling Saethra , Beecher Michael D. 
Published: February 2020

AbstractIn most songbirds, the processes of song learning and territory establishment overlap in the early life and a young bird usually winds up with songs matching those of his territorial neighbors in his first breeding season. In the present study, we examined the relationships among the timing of territory establishment, the pattern of song learning and territorial success in a sedentary population of song sparrows (Melospiza melodia). Males in this population tend to learn their songs from their neighbors and consequently they show high song sharing with neighbors and use these shared songs preferentially in interactions with them. Males also show significant variation in the timing of territory establishment, ranging from their natal summer to the next spring. Using a three‐year dataset, we found that the timing of territory establishment did not systematically affect the composition of the song repertoire of the tutee: early establishers and late establishers learned equally as much from their primary tutors and had a similar number of tutors and similar repertoire sizes, nor did timing of territory establishment affect subsequent survival on territory. Therefore, the song‐learning program of song sparrows seems versatile enough to lead to high song sharing even for birds that establish territories relatively late.
Use of a jugular vein model for the instruction of equine intravenous catheter placement by third‐and fourth‐year veterinary students
Authors: Hobbs K. J. , Johnson P. J. , Scharf M. E. , Cross D. T. , Wallace L. L. 
Published: February 2020

SummarySuccessful placement of an i.v. catheter in horses is a core competency required by the AVMA COE accreditation policy (section 7.11, #2,#3,#5). Therefore, we determined whether the use of a novel intravenous (i.v.) catheter placement training tool would improve confidence, time to successful placement and accuracy with which third‐ and fourth‐year veterinary students acquire competence regarding this skill in adult horses. Students lacking earlier experience with i.v. catheter placement in horses were randomly assigned to either Group 1 (n = 15) or 2 (n = 10). Students with prior experience with the technique were assigned to Group 3 (n = 14). Group 1 students were instructed on i.v. catheter placement using the model and then assessed using a live horse. Group 2 students were instructed on i.v. catheter placement using a live horse and then assessed using a live horse. Group 3 students were assessed using a live horse. Assessments included number of placement attempts, number of redirects and time needed to achieve correct intraluminal placement. Student perceptions regarding the use of this model for the purpose of learning i.v. catheter placement in horses were evaluated using a questionnaire. Results of this study demonstrated that students receiving initial instruction with the model achieved better scores in terms of both time to accomplish the task and accuracy for catheter placement in a live horse when compared with students that received their first instruction on a live horse. The use of this i.v. catheter placement training tool therefore served to lessen the cost of training and to minimise animal discomfort during this component of veterinary student training.
A guide to regulation of the formation of biomolecular condensates
Authors: Bratek‐Skicki Anna , Pancsa Rita , Meszaros Balint , Van Lindt Joris , Tompa Peter 
Published: February 2020

Cellular organelles that lack a surrounding lipid bilayer, such as the nucleolus and stress granule, represent a newly recognized, general paradigm of cellular organization. The formation of such biomolecular condensates that include ‘membraneless organelles’ (MLOs) by liquid–liquid phase separation (LLPS) has been in the focus of a surge of recent studies. Through a combination of in vitro and in vivo approaches, thousands of potential phase‐separating proteins have been identified, and it was found that different cellular MLOs share many common components. These perplexing observations raise the question of how cells regulate the timing and specificity of LLPS, and ensure that different MLOs form and disperse at the right moment and cellular location and can preserve their identity and physical separation. This guide gives an overview of basic regulatory mechanisms, which manifest through the action of intrinsic regulatory elements, alternative splicing, post‐translational modifications, and a broad range of phase‐separating partners. We also elaborate on the cellular integration of these different mechanisms and highlight how complex regulation can orchestrate the parallel functioning of a dozen or so different MLOs in the cell.
Cut‐and‐chip harvester material capacity and fuel performance on commercial‐scale willow fields for varying ground and crop conditions
Authors: Eisenbies Mark H. , Volk Timothy A. , de Souza Daniel P. L. , Hallen Karl W. 
Published: February 2020

AbstractShrub willow (Salixspp.) is capable of producing commercially attractive amounts of biomass in short rotations, but harvesting costs and logistics remain a concern. There is a particular need for information about harvesting operations on larger, commercial short‐rotation woody crop systems. Another recent issue on commercial fields in northern New York is commercial growers conducting harvests during the growing season rather than the recommended dormant season when fields may be too wet to harvest. This study evaluated and modeled the in‐field performance of a cut‐and‐chip harvester for almost 700 wagonloads of chips operating in commercial willow fields in a wider array of crop and field conditions than have been previously reported. Analysis indicated that the time of harvest (leaf‐on or leaf‐off) and whether site conditions were wet or dry affected the harvester's material capacity. Mean material capacity was greatest for leaf‐off, dry conditions (71.8 Mg/hr) and lowest for leaf‐on harvests, which were similar for wet (30.4 Mg/hr) and dry conditions (29.7 Mg/hr). Mean crop specific fuel consumption ranged between 1.3 and 3.3 L/Mg, but can get considerably higher for standing biomasses below 40 Mg/ha. Wet ground conditions and leaf‐on harvests tend to decrease material capacity and increase fuel consumption as the harvester has to divert power to forward movement and material processing. Relationships for material capacity and fuel consumption based on standing biomass, time of harvest and ground conditions will be essential for evaluating and modeling the economic and environmental impacts of commercial‐scale willow operations.
Eternity and the Future: A Critique of the Plotinian Myth in Pannenberg’s Theology
Authors: Lee Sang Hoon 
Published: February 2020

AbstractFor Pannenberg, the eschatological future is considered as the locus where the ultimate causation lies. Such an idea shapes Pannenberg’s doctrinal accounts of Christ and the Trinity in an idiosyncratic way. However, as this article will indicate, the idea is derived from the Plotinian myth that time can become a whole and so a vessel of divine infinity when it reaches the End. Dispensing with the faulty assumption but retaining the concept of the priority of the future, this article will argue that divine eternity as the totality can engage with history directly at any point of time, without a detour via the eschaton.
Germinal centers and autoantibodies
Authors: Young Clara , Brink Robert 
Published: February 2020

AbstractPreventing self‐reactive lymphocytes from participating in effector responses is fundamental to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of complementary mechanisms are known to act upon the primary B‐ and T‐cell repertoires to this effect, eliminating or silencing lymphocytes expressing self‐reactive antigen receptors generated through V(D)J recombination in early lymphoid precursors. In the case of B cells, secondary diversification of antigen receptor repertoire by somatic hypermutation (SHM) provides an additional challenge, especially because this occurs in germinal center (GC) B cells that are actively responding to antigen and primed for differentiation into antibody‐producing plasma cells. While it is clear that self‐tolerance mechanisms do act to prevent antibody production by self‐reactive GC B cells, it is also apparent that most pathogenic autoantibodies carry somatic mutations and so have derived from a GC response. Recent advances in the analysis of autoantibody‐producing cells associated with human autoimmune diseases together with insights gained from animal models have increased our understanding of the relationships between GCs, SHM and autoantibody production. Here we discuss these developments and focus in particular on how they have illuminated the genesis and pathogenesis of one archetypal autoantibody, rheumatoid factor.