bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcription factor MEF2D regulates aberrant expression of ACSL3 and enhances sorafenib resistance by inhibiting ferroptosis in HCC
Authors: Li Xue , Chen Shimin , Shi Yuanyuan , Wang Yuanjing , Wang Xuanzhe , Lin Qian , Wu Chao , Fang Wenshuo , Sun Peng , Ma Leina 
Published: December 2024

BackgroundSorafenib is a first-line treatment for hepatocellular carcinoma (HCC); however, acquired resistance often results in a poor prognosis, indicating a need for more effective therapies. Sorafenib induces cell death through an iron-dependent mechanism known as ferroptosis, which is closely associated with the onset and progression of HCC.MethodsThis study investigated the role of ACSL3 in sorafenib resistance and ferroptosis in HCC. The expression of ACSL3 was analyzed in HCC tissues and cell lines. Ferroptosis levels and cell viability were assessed in ACSL3-silenced HCC cells treated with sorafenib. The regulatory relationship between the transcription factor MEF2D and ACSL3 was evaluated using promoter binding assays and gene expression analysis.ResultsACSL3 was aberrantly expressed in HCC and promoted the progression of non-alcoholic fatty liver disease (NAFLD) to HCC. Elevated ACSL3 expression inhibited ferroptosis and enhanced resistance to sorafenib. The transcription factor MEF2D directly regulated the upregulation of ACSL3 expression. MEF2D bound to the promoter regions of ACSL3 to enhance its transcription and negatively regulate ferroptosis in HCC.ConclusionThis study demonstrated for the first time that MEF2D regulated ACSL3 expression and mediated sorafenib resistance by inhibiting ferroptosis in HCC, providing a potential therapeutic target for improving HCC outcomes.
Transdiagnostic mechanisms of mental health during the COVID-19 pandemic: associations of childhood trauma, maladaptive personality traits, emotion regulation, mentalizing, and pandemic-related distress
Authors: Holl Julia , Berning Anna , Kling Laura , Taubner Svenja , Georg Anna K. , Volkert Jana 
Published: December 2024

IntroductionThe outbreak of the COVID-19 pandemic has led to increased psychological distress. Transdiagnostic factors, including childhood trauma, maladaptive personality traits (MPTs), mentalizing, and emotion dysregulation are considered relevant to the development and maintenance of mental health problems. These factors probably play a significant role in individuals’ reactions to pandemic-related distress (PR distress). The aim of this study is to examine the associations with these transdiagnostic factors in relation to PR distress and psychopathological symptoms.Materials and methodsUsing a cross-sectional study design, we investigated a convenience sample of 6,451 adults (mean age = 44.1; SD = 11.8; 69.1% female, 30.3% male, 0.01% diverse) recruited via social media platforms in German-speaking countries (August 2020 – February 2021) by utilizing self-report instruments (PID5BF+, MentS, DERS-SF, PHQ-9, GAD-7, a composite PR distress score). Structural equation modeling was performed for data analysis.ResultsThe results revealed significant associations between different types of childhood trauma and MPTs (−0.14 &lt; β &lt; 0.48) as well as a parallel mediation of the relationship between MPTs and psychopathological symptoms via mentalizing (βanxiety = −0.03; βdepression = 0.01) and emotion dysregulation (βanxiety = 0.24; βdepression = 0.23).DiscussionMentalizing and emotion dysregulation seem to play a significant role in relation between childhood trauma and MPTs and psychopathological symptoms during the COVID-19 pandemic. Thus, transdiagnostic factors may be a valuable target for the development of interventions aiming to reduce psychological distress related to a pandemic or other crises events. Specific prevention and intervention methods that target emotion dysregulation and mentalizing could help vulnerable individuals, particularly those with childhood trauma and MPTs, to protect against or alleviate the detrimental effects of PR distress on their mental health.
Long-term trends in educational inequalities in alcohol-attributable mortality, and their impact on trends in educational inequalities in life expectancy
Authors: Zazueta-Borboa Jesús-Daniel , Van Hemelrijck Wanda M. J. , Zengarini Nicolás , Sizer Alison , Kunst Anton E. , Martikainen Pekka , Janssen Fanny 
Published: December 2024

BackgroundPrevious studies on socio-economic inequalities in mortality have documented a substantial contribution of alcohol-attributable mortality (AAM) to these inequalities. However, little is known about the extent to which AAM has contributed to time trends in socio-economic inequalities in mortality.ObjectiveTo study long-term trends in educational inequalities in AAM and assessed their impact on trends in educational inequalities in life expectancy in three European countries.MethodsWe analyzed cause-specific mortality data by educational group (low, middle, high) for individuals aged 30 and older in England and Wales, Finland, and Turin (Italy) over the 1972–2017 period. To estimate AAM, we used the multiple causes of death approach for England and Wales and Finland (1987–2017), and a recently introduced method for Turin (Italy). We used segmented regression analysis to study changes in absolute educational inequalities in AAM, measured by the Slope Index of Inequality (SII). We assessed the contribution of AAM to trends in educational differences in remaining life expectancy at age 30 (e30) using cause-deleted life tables.ResultsAAM increased more among the low-educated than the high-educated in England and Wales (1972–2017) and Finland (1987–2007). In contrast, in Finland (2007 onwards) and Turin (1972–2017), AAM decreased more among the low-educated than the high-educated. In England and Wales, AAM contributed 37% (males) and 24% (females) of the increase in educational inequalities in e30. In Finland in 1987–2007, AAM contributed 50% (males) and 34% (females) of the increase in educational inequalities in e30. AAM also contributed to recent trend breaks, such as to the onset of an increase in educational inequalities in e30 in England and Wales, and to the onset of a decline in educational inequalities in e30 in Finland after 2007.DiscussionAAM mortality contributed substantially not only to levels of, but also to changes in educational inequalities in e30 in the studied populations. Reducing the impact of alcohol on mortality among low-educated groups may positively affect trends in educational inequalities in life expectancy.
Influence of government policies on handwashing and vaccine uptake in Kenya, Uganda, and Tanzania to prevent and control COVID-19: a systematic review
Authors: Muchangi Josphat Martin , Mturi James , Mukasa Hajra , Kithuki Kioko , Kosgei Sarah Jebet , Kanyangi Lennah Muhoja , Moraro Rogers , Kamau Samuel , Nankanja Maureen 
Published: December 2024

IntroductionThe government's role in influencing policies related to Coronavirus disease 2019 (COVID-19) vaccine distribution and handwashing practices is essential in controlling the spread of severe acute respiratory syndrome coronavirus 2.MethodsThis study aimed to systematically review published studies to explore the influence of government policies on handwashing and vaccine uptake in Kenya, Uganda and Tanzania to prevent and control COVID-19. A comprehensive search strategy was applied across three databases, and eligibility was determined using strict inclusion and exclusion criteria. We reviewed 9 of 136 research papers following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines.ResultsThe findings revealed that the government has a role in influencing policies related to COVID-19 vaccine distribution and handwashing uptake. Employment of public health campaigns and communication strategies by the government in Uganda increased vaccine acceptance and hand hygiene uptake. Similarly, government efforts to make hand hygiene accessible increased the uptake of handwashing in Tanzania. In Kenya, government efforts to increase access to soap and clean water in informal settlements and markets resulted in increased adherence to handwashing practices. Further, government incentives such as cash increased vaccination rates while vaccination reminders combined with cash incentives increased childhood immunization coverage.DiscussionOverall, this review indicates that monitoring and enforcing compliance increases vaccine and handwashing uptake across the three countries. The effectiveness of government policies on handwashing and vaccine uptake is influenced by factors such as safety, efficacy and access to information, among others. Therefore, there is a need to address these factors for the successful implementation of these policies.Systematic review RegistrationPROSPERO ID CRD42023396319, https://www.crd.york.ac.uk/prospero/.
Disparities exist among US adolescents in the receipt of transition to adult healthcare services: the differential impact of social determinants of health, healthcare needs, and COVID-19
Authors: Girdwood Tyra C. , Silva Susan G. , Maslow Gary R. , Docherty Sharron L. 
Published: December 2024

IntroductionWe examined the influence of special healthcare needs, onset of the COVID-19 pandemic, and their interaction on receiving transition services to prepare for future adult care among US adolescents, and whether social determinants of health moderated the relationship of these factors with receiving transition services.MethodsWe analyzed the National Survey of Children's Health (2019, 2020–2021) using adjusted multivariable logistic regression models. We assessed a repeated cross-sectional, nationally representative sample of adolescents aged 12–17 years old. Sampling weights were used to generalize samples to the populations of interest. The main outcome was receipt of transition services to prepare for future adult healthcare. Measures included pre vs. post COVID-19 onset, special healthcare needs, and social determinants of health (health insurance, food sufficiency, neighborhood safety, household language, race/ethnicity, and household poverty level). Sex and two-parent households were included as covariates.ResultsA total of 45,935 adolescents were included, with N=12,230 in the pre COVID-19 group and N=33,705 in the post COVID-19 group. We found statistically significant higher odds of receiving transition services among adolescents with special healthcare needs (95 CI = 1.23, 1.58), females (95 CI = 1.09, 1.39), and during pre COVID-19 (95 CI = 1.14, 1.45). Private insurance (95 CI = 1.03, 1.37), English as primary household language (95 CI = 1.19, 2.27), and race/ethnicity were significant predictors of receipt of transition services. Neighborhood safety significantly moderated (95 CI = 1.70, 6.60) the relationship between special healthcare needs and receipt of transition services.DiscussionThis population-based study identified significant disparities in receipt of transition services provided to US adolescents via the differential impact of social determinants of health, special healthcare needs, and COVID-19 onset on receipt of services.
Antiplatelet Prophylaxis Reduces the Risk of Early Hepatic Artery Thrombosis Following Liver Transplantation in High-Risk Patients
Authors: Minciuna Iulia , De Jonge Jeroen , Den Hoed Caroline , Maan Raoel , Polak Wojciech G. , Porte Robert J. , Janssen Harry L. A. , Procopet Bogdan , Darwish Murad Sarwa 
Published: December 2024

The prevention of hepatic artery thrombosis (HAT) is pivotal for graft survival immediately after liver transplantation (LT). This study aimed to identify risk factors (RF) for early HAT (eHAT) and assess the benefit of antiplatelet prophylaxis (AP). This retrospective single-center study included 836 adult patients who underwent LT between 2007 and 2022. AP was administered for 3 months in N = 127 patients for surgical reasons. In total, 836 patients underwent LT, of whom 5.5% developed eHAT. In multivariable analysis, arterial anastomotic redo (aHR = 4.33), arterial reconstruction (aHR = 3.72) and cryptogenic liver cirrhosis (aHR = 4.25) were independent RFs for eHAT and AP appeared to be protective (aHR = 0.18). Indeed, in patients with at least one RF who received AP (RF+AP+, n = 94), the eHAT rate was significantly lower (3.2% vs. 21.3%, p &lt; 0.001) than in those with RF who did not receive AP (RF+AP−, n = 89). The effect was even more pronounced when focusing on surgical RF alone (i.e., redo and/or reconstruction) with an additional improvement in 1 year graft survival of 85.3% vs. 70.4%, p = 0.02. AP did not pose an increased risk of bleeding. In conclusion, the main RFs for eHAT include arterial anastomotic redo, arterial reconstruction and cryptogenic liver cirrhosis as LT indications. Our results suggest that AP may protect against eHAT development in these high-risk patients.
Retrophyllum rospigliosii (Pilg.) C.N. Page en la población de micorrizas arbusculares en el bosque de Huamantanga
Authors: Flores Flores Leiwer , Guerra Lu José Kalion , Arteaga Cuba Marcela Nancy , Gallo Álvarez Alan Guillermo , Carhuaricra Espinoza Karina Violeta , Cerna Cueva Alberto Franco 
Published: December 2024

Introducción: Las micorrizas arbusculares, asociaciones simbióticas entre hongos y raíces de plantas, desempeñan un papel fundamental en la nutrición y supervivencia de muchas especies forestales. El objetivo del estudio fue identificar morfológicamente a la población de micorrizas arbusculares, en función al estado de desarrollo del Retrophyllum rospigliosii (Pilg.) C.N. Page en el bosque de Huamantanga, Jaén- Perú. Materiales y métodos Enfoque cuantitativo, tipo descriptiva. Se seleccionaron 3 zonas de muestreo de suelo y raíces en las categorías brinzal, latizal y fustal, la zona 1 (sector cola de ardilla), la zona 2 (sector camino cola de ardilla) y La zona 3 (sector Nueva Jerusalén) Resultados: De acuerdo al análisis estadístico (ANVA), se rechaza la hipótesis de igualdad de medias, por lo que sí existe diferencia significativa entre las categorías de regeneración natural. Discusión: Los resultados obtenidos en este estudio revelan una comunidad de hongos micorrízicos arbusculares (HMA) dominada por los géneros Glomus, Entrophospora y Acaulospora, asociados a Retrophyllum rospigliosii en el bosque de Huamantanga. Igualmente, se pudo identificar una diversidad de morfoespecies con un total de 16 morfoespecies distribuidas en los géneros Acaulospora, Entrophospora y Glomus. Conclusiones: La mayor colonización fue para brinzal, en raíces 93.0 %, en suelo 91.7 %; seguido de latizal, en raíces 88.3 %, en suelo 89 %; luego de fustal, en raíces 86.7 %, en suelo 87.3 %. Los HMA asociados Retrophyllum rospigliosii (Pilg.) C.N. Page., identificados son: Acaulospora 4 morfo-especies, Entrophospora 5 morfo-especies, y Glomus 7 morfo-especies.
Análise do perfil epidemiológico da Sífilis em gestante no município de Porto Nacional, Tocantins, no período de 2019 a 2023
Authors: Azevedo José Roberto Aires da Silva , Bandeira Camila Giovana , Pettenon Leonardo Cassemiro Coelho , Turíbio Thompson de Oliveira 
Published: December 2024

A vigilância epidemiológica da sífilis é firmada por meio de notificação compulsória dos serviços de saúde privada e pública em todo o Brasil, com todas as informações registradas no SINAN e disponibilizadas no DATASUS. Diante disso, tem-se como objetivo verificar o perfil epidemiológicos da sífilis em gestante no município de Porto Nacional, Tocantins, no período de 2019 a 2023. Trata-se de um estudo transversal com análise de série temporal no período de 2019 a 2023, utilizando dados obtidos pelo DATASUS. Os dados revelaram que, durante o tempo análisado (2019 a 2023) foram registradas 126 notificações de sífilis em gestantes. A classe mais frequente dessa variável condizem com a faixa etária de 20 a 39 anos, continuada pela faixa etária de 15 a 19 anos. A escolaridade com maior dominância foi a de ensino médio completo, contendo 45 casos, seguida do ensino médio incompleto, que obteve 21 casos. A Raça que mais apresentou notificações foi a parda com 101 casos, seguida da raça preta com 12 casos. Os casos foram apresentados na forma primária em sua grande maioria, seguido da forma latente. Embora seja amplamente ofertado e preconizado pelo sistema único de saúde - SUS o tratamento e o diagnóstico de todas as pacientes notificadas, gratuitamente, a sífilis em gestante ainda é um grave problema de saúde pública. Assim, nota-se a relevância em analisar os casos, bem como, seus fatores, visando desenvolver ações preventivas e de controle.
References to the abused body in the theatrical actor’s performance
Authors: Salah Ezzat Hanadi , Atallah Abdul Ali Haider 
Published: December 2024

تنوعت المسميات والمفاهيم في تعريف فن الممثل بوصفه احد اهم الأدوات التي تقوم عليه العملية المسرحية الى جانب عناصر العرض الأخرى ليكون، شارحا ومقلدا ومحاكيا ومجسدا للدور على خشبة المسرح، بوجود الجمهور الذي يكون عنصر مهم لنجاح اللعبة المسرحية ،لكن في بحثنا هذا نستبدل مصطلح (الممثل) بـ(المؤدي) الذي صاغ بنية ادائية مختلفة عبر هدم مستلزمات الممثل من نص وجدار رابع مبتعدا عن تحليل وتجسيد الشخصية مستعينا بجسده المادي فقط، ليؤسس علاقة مختلفة عن ما هو متعارف عليها في الماضي ،تكون ادواتها (الجسد المعنف) نوع ادائي يحاور غرائز الأنسان ويثير شراسته المستمدة من تكوينه الطبيعي داخل البيئة الحياتية ،مستعينا بأدوات جارحه لخلق فضاء طقسي بينه وبين المتلقي لاعبا على حواسه ومشاعره لإنتاج معاني ودلالات جديدة تهدم بها الثوابت القديمة لصياغة معنى من خلال جسد المؤدي المعنف داخل عملية ادائية مركبة ومعقدة مبنيه على حواس فكرية وحسية وذهنية ،فهي عملية متغيرة حسب المفاهيم والأنظمة الأدائية التي تعمل وفق سياق الهدم والبناء وهي بذلك تسعى الى صياغة فضاء فني كل ما يحتويه تابع لجسد المؤدي الواقعي الذي غيب سمات الشخصية التي يؤديها الممثل واستبدلها بسماته الذاتية ليؤثر بذلك على المعنى المستنبط من هكذا عروض تزعزع ثوابت سابقه للدال والمدلول وتوليد معاني اخرى.
وقد اتضح ذلك عبر فصول البحث متمثلة بالفصل الأول (الإطار المنهجي) والفصل الثاني والذي تكون من المبحث الأول (المفاهيم الاجتماعية والنفسية للجسد المعنف) والمبحث الثاني (الجسد المعنف في الاداء المسرحي) وصولا الى الفصل الثالث (اجراءات البحث) والذي تضمن تحليل مسرحية (خريف) والفصل الرابع (النتائج والاستنتاجات)ونذكر بعضها:

استطاعت الأجساد المعنفة ان تبرهن على قابليتها بالهدم والبناء من خلال تحولاتها النفسية والفسيولوجية ،فهي تارة (مطمئنة قوية ومتزنة) وتارة اخرى نجدها (خائفة ضعيفة شبه انفصاميه).
قدرة (الممثل العراقي) على خلق مقاربات بين (اعادة تقديم النص) و(عروض تعذيب الذات) بتوغل عناصر (الممثل، النص ، الخشبة).
فاعلية تطبيق نموذج للمعالجات الجرافيكية قائم على تقنية سكامبر لإثراء جمالية الوحدة التصميمية
Authors: الأنصاري أفنان 
Published: December 2024

يهدف البحث إلى قياس مدى فاعلية تطبيق نموذج للمعالجات الجرافيكية، وقائم على تقنية سكامبر في إثراء جمالية الوحدة التصميمية من خلال اختبار الفرضيات الإحصائية باتباع المنهج شبه التجريبي، حيث تمثلت العينة في 31 مفردة، تقوم بإنتاج 62 عينة من الوحدات التصميمية، منها 31 وحدة قبل تطبيق نموذج المعالجات الجرافيكية القائم على تقنية سكامبر، ومنها 31 وحدة تصميمية بعد تطبيق النموذج، والتي تقاس مستوى جماليتها من قبل الخبراء، وقد جاءت النتائج لتؤكد على وجود فروق ذات دلالة إحصائية بين مستوى جمالية الوحدة التصميمية التي تم إنتاجها قبل تطبيق النموذج، وبين مستوى جمالية الوحدات التصميمية التي أنتجت بعد تطبيق النموذج لصالح الأخيرة، كما تم إثبات فاعلية تطبيق النموذج على مستوى جمالية الوحدة التصميمية من خلال قياس حجم أثر تطبيق نموذج المعالجات الجرافيكية ،القائم على تقنية سكامبر على مستوى جمالية الوحدة التصميمية، والذي أظهر تأثيراً كبيراً ومعنوياً، ومنه أوصى البحث بإجراء المزيد من الأبحاث حول التقنيات الإبداعية التي يمكن تطبيقها على المعالجات الجرافيكية.
Знания и информация в контексте естественного и искусственного интеллекта
Authors: Максимов Н.В. 
Published: December 2024

Рассматриваются обобщенный состав и структура рациональной деятельности. Модель мыслительных процессов представляется в виде взаимодействующих функциональных блоков переработки и хранения информационных структур. В контексте деятельностного подхода рассматриваются основные понятия естественного и искусственного интеллекта, а также определены характеристические свойства сущности "знания": систематизированность, предметность, квалифицированность, распределенность, гранулярность. Обосновывается необходимость понимания интеллекта в симбиозе со знанием и деятельностью.
The generalised composition and structure of rational activity are considered. The model of thinking processes is presented in the form of interacting functional blocks of processing and storing information structures. In the context of the activity approach the basic concepts of natural and artificial intelligence are considered, and the characteristic properties of the essence of "knowledge" are defined: systematisation, subject matter, qualification, distribution, granularity. The necessity of understanding intelligence in symbiosis with knowledge and activity is substantiated.
О роли национальной киноиндустрии в экономике страны: наукометрические и статистические методы оценки
Authors: Васильева В.С. 
Published: December 2024

Рассматривается развитие сферы киноиндустрии по отношению к экономическому развитию России. Используемые методы анализа информации основаны на наукометрических и статистических показателях. Наукометрические показатели включают в себя анализ роста (снижения) количества публикаций в динамике за ряд лет; публикаций российских авторов в российских и зарубежных журналах (территориальный охват); наиболее востребованных журналов, в которых авторы предпочитают публиковать результаты своих исследований; аффилиаций авторов и др. Для информационной поддержки принятия управленческих решений проведен анализ динамики статистических показателей, дополнительно проверен уровень их корреляции. Для оценки связей были сформированы матрицы парных коэффициентов корреляции, позволяющие определять силу и устойчивость связей между показателями за период 2010-2021 гг. Сделаны выводы, что почти все рассмотренные инструменты в сфере кинематографа способны воздействовать как на социальную сферу, так и на экономическое развитие страны в целом, однако эта зависимость не однонаправленная. Экономическое развитие, в свою очередь, напрямую влияет на устойчивый рост показателей, характеризующих развитие отраслей культуры России, для которых крайне важно воспроизводство и прирост высококвалифицированных кадров, развитие технологий и инноваций, в том числе, как показал анализ, посредством использования сети Интернет.
The article examines the development of the film industry in relation to Russia's economic development. The methods used to analyse information are based on scientometric and statistical indicators. The scientometric indicators include analyses of the growth (decline) in the number of publications over a number of years; publications of Russian authors in Russian and foreign journals (territorial coverage); the most popular journals in which authors prefer to publish the results of their research; authors' affiliations; etc. To provide information support for managerial decision-making, the dynamics of statistical indicators was analysed, and the level of their correlation was additionally checked. In order to assess the relationships, the matrices of pair correlation coefficients were formed to determine the strength and stability of relationships between the indicators for the period 2010-2021. The conclusions are drawn that almost all the considered instruments in the sphere of cinematography are able to influence both the social sphere and economic development of the country as a whole, but this dependence is not unidirectional. Economic development, in turn, directly affects the sustainable growth of indicators characterising the development of Russia's cultural industries, for which the reproduction and growth of highly qualified personnel, the development of technologies and innovations, including, as the analysis has shown, through the use of the Internet.