bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twenty Years of Integrated Disease Surveillance and Response in Sub-Saharan Africa: Challenges and Opportunities for Effective Management of Infectious Disease Epidemics
Authors: Mremi Irene , George Janeth , Rumisha Susan F. , Sindato Calvin , Mboera Leonard E.G. , Kimera Sharadhuli I. 
Published: September 2020

Abstract
Background: Public health surveillance requires valid, timely and complete health information for early detection of outbreaks. Countries in Sub-Saharan Africa (SSA) adopted Integrated Disease Surveillance and Response (IDSR) strategy in 1998 in response to an increased frequency of emerging and re-emerging diseases in the region. This systematic review aimed to analyse how IDSR implementation has embraced advancement in information technology, big data analytics techniques and wealth of data sources to strengthen detection and management of infectious disease epidemics in SSA. Methods: A search for eligible articles was done through HINARI, PubMed, and advanced Google Scholar databases. The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols checklist. Using the key search descriptors, 1,809 articles were identified and screened at two stages and 45 studies met the inclusion criteria for detailed review.Results: Of the 45 studies, 35 were country-specific, seven studies covered the region and three studies covered 3-4 countries. A total of 24 studies assessed the IDSR core functions while 42 studies assessed the support functions. Twenty-three studies addressed both the core and support functions. Most of the studies involved Tanzania (9), Ghana (6) and Uganda (5). The implementation of the IDSR strategy has shown improvements mainly in the support functions. The Health Management Information System (HMIS) has remained the main source of IDSR data. However, the HMIS system is characterised by inadequate data completeness, timeliness, quality, analysis and utilisation as well as lack of integration of data from sources other than health care facilities. Conclusion: In most SSA, HMIS is the main source of IDSR data, characterised by incompleteness, inconsistency and inaccuracy. This data is considered to be biased and reflects only the population seeking care from healthcare facilities. Community-based event-based surveillance is weak and non-existence in the majority of the countries. Data from other systems are not effectively utilized and integrated for surveillance. It is recommended that SSA countries consider and adopt multi-sectoral, multi-disease and multi-indicator platforms that integrate the existing surveillance systems with other sources of health information to provide support to effective detection and prompt response to public health threats.
Prevalence and Socio-Demographic Correlates of Tobacco and Alcohol Use in Four Sub-Saharan African Countries: A Cross-Sectional Study of Middle-Aged Adults
Authors: Boua Palwende Romuald , Soo Cassandra Claire , Debpuur Cornelius , Maposa Innocent , Nkoana Shai , Mohamed Shukri F , Choma Solomon , Oduro Abraham , Asiki Gershim , Mickelsfield Lisa K , Gómez-Olivé Francesc Xavier , Sorgho Hermann , Mall Sumaya , Ramsay Michele 
Published: September 2020

Abstract
Background: Substance misuse is a global public health problem. In addition to social and economic concerns; consumption of tobacco and alcohol is associated with susceptibility to cardiovascular, respiratory, and infectious diseases, and cancers, as well as risk of transitioning to substance use disorders. African data suggest regional differences in the prevalence and patterns of substance use, but there is limited data from African countries. This cross-sectional population study of middle-aged adults, aims to examine prevalence and socio-demographic correlates of substance use in four sub-Saharan African countries, in rural and urban settings. Methods: Participants aged between 40 and 60 years were recruited from six research centres as part of the Africa Wits-INDEPTH partnership for Genomic Research study. Data on patterns of tobacco and alcohol consumption was captured by questionnaire, and alcohol consumption was further assessed using the CAGE (cut-annoyed-guilty-eye) questionnaire. Results: Data from 10703 participants suggested that more men (68.4%) than women (33.3%) were current substance users. The prevalence of current smoking was significantly higher in men than in women (34.5% vs 2.1%, p<0.001). Smokeless tobacco was used more by women than men (14.4% vs 5.3%, p<0.001). Current smoking was associated with alcohol consumption, and smoking cessation in men was associated with being a former drinker, higher socioeconomic status, and if married or cohabiting. Current alcohol consumption was higher in men, compared to women (60.3% vs 29.3%), and highest in men from Soweto (70.8%) and women from Nanoro (59.8%). The overall prevalence of problematic alcohol consumption among men was 18.9%, and women 7.3%. Men were significantly more likely to consume alcohol, and to develop drinking problems. Problematic drinking was more common in men, in divorced or widowed individuals, and in current smokers.Conclusions: Regional variation in the patterns and prevalence of substance use was observed across study sites, and in rural and urban settings. The high levels of substance use recorded in this study are of concern due to the increased risk of associated morbidities. Further longitudinal data will be valuable in determining trends in substance misuse in Africa.
The Complete Mitochondrial Genome of The American Palm Cixiid, Haplaxius Crudus (Hemiptera: Cixiidae)
Authors: Komondy Lidia , Huguet-Tapia Jose , Ascunce Marina S. , Helmick Ericka , Goss Erica M. , Bahder Brian 
Published: September 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
CT Measurement of Proximal Femoral Medullary Cavity Morphology in Healthy Subjects from Northern China
Authors: Zhao Ran , Cai Hong , Zhang Ke , Tian Hua 
Published: September 2020

Abstract
Purpose: In total hip arthroplasty (THA), optimal stability and fixation is achieved via tight adaptation of the prosthesis to the bone. This study aimed to analyze the proximal femoral medullary cavity morphology of Chinese subjects on three-dimensional reconstructed imagery to explore the factors influencing these parameters.Methods: CT was performed on 63 healthy subjects from northern China (94 hips; 31 men, 63 women). Three-dimensional CT reconstruction of the proximal femoral medullary cavity was performed using Mimics 22.0 software. The anatomical parameters related to THA were measured to examine the relationships between sex, age, and femoral length. These parameters were compared with previously published data.Results: The internal and external coronal diameters of the femoral medullary cavity, and the anterior and posterior sagittal diameters had different contracting trends. There were correlations between the femoral length, femoral head diameter, and coronal diameter, and between the sagittal diameter and cross-sectional area of the medullary cavity. Age was negatively correlated with the CFI(canal flare index). Sex was correlated with the cross-sectional coronal/sagittal diameters, but not with the canal flare index. The proximal end of the medullary cavity was similar to that reported in Caucasians, but the Asian medullary cavity was narrower distal to the level of the lesser trochanteric line.Conclusions: THA-related anatomy was affected by sex, age, and subpopulation. Compared with sex, age had a greater effect on the fit of the stem to the femoral canal. Each patient must be treated individually, as the anatomical structure varied between individuals.
The effect of melatonin on interleukins 22 and 13 in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass: A Clinical Trial
Authors: Jouybar Reza , Jannati Mansour , Khademi Saeed 
Published: September 2020

Abstract
Objective: Coronary artery bypass graft surgery with cardiopulmonary bypass (CABG) is one treatment for patients with coronary artery disease. After CABG, a series of inflammatory processes occur which affect other organs of the body and even cause severe organ damage and subsequently a worse prognosis. The purpose of this study was to evaluate the effect of pre-surgically administered melatonin on interleukins 22 and 13 in patients undergoing CABG.Results: In this study, 22 patients were evaluated, 10 patients (45.5%) in the Melatonin group, and 12 patients (54.5%) in the control group. The mean level of IL-22 at all time-points in T2, T3, and T4 was significantly lower in the Melatonin group (P <0.05). There was also a significant increase in IL-22 in both groups at T4 compared to T1. There was no significant difference between the two groups in IL-13 at any time, but the Melatonin group at T2 had a significant decrease in IL-13 compared to T1. This study showed that preoperative melatonin administration could prevent the increase of IL-22 but not IL-13.
Accuracy of a Bedside Swallow Test After Extubation in ICU: A Prospective Validation of a Clinical Test Compared to a Fiberoptic Endoscopy.
Authors: Maamar Adel , Parent Valentine , Guérot Emmanuel , Berneau Pauline , Frérou Aurélien , Tulzo Yves Le , Laviolle Bruno , Jégoux Franck , Gacouin Arnaud , Tadié Jean-Marc 
Published: September 2020

Abstract
Background: Swallowing disorders (SDs) are frequent after extubation in intensive care unit (ICU) exposing patients to aspiration pneumonia. There is no validated bedside swallowing evaluation (BSE) after extubation. We aimed to evaluate the accuracy of our BSE in comparison with fiberoptic endoscopic evaluation of swallowing (FEES) in critically ill patients after extubation, and to identify the incidence and risk factors of SD.Methods: After a preliminary study in a first center, we conducted a 1-year prospective study as a validation cohort in a second center. Patients intubated for longer than 48 hours were included. Exclusion criteria were a known laryngeal pathology, a preexisting SD and an admission for stroke. FEES of the larynx and BSE were assessed within 24 hours after extubation to compare the accuracy of the BSE to the FEES procedure.Results: One hundred and twenty eight patients were included, respectively 69 and 79 in the preliminary study and the validation cohort. Thirteen of 69 (19%) and 33/79 (42%) had SD assessed by FEES. The area under curve (AUC) reached respectively 0.86 (95% CI 0.73-0.98) and 0.83 (95% CI 0.74-0.92). Sensitivities were 77% (95% CI 0.54-0.99) and 85% (95% CI 0.73-0.94), specificities 94% (95% CI 0.87-0.98) and 80% (95% CI 0.7-0.91), and negative predictive values (NPV) were 95% and 90% in respectively preliminary study and validation cohort. Independent risk factors for SD were duration of intubation (OR=1.08; 95% CI 1.02-1.17, p=0.03) and hemodynamic failure (OR=4.46; 95% CI 1.27-21, p=0.03).Conclusion: Our BSE is accurate to detect SDs after extubation in critically ill patients and can easily be implemented in an ICU setting.
Modified Kocher-Langenbeck Approach for the Treatment of Posterior Wall or Column Acetabular Fractures: The One-Incision Two-Window Method
Authors: Yang Tien-Yu , Chuang Po-Yao , Huang Tsan-Wen , Huang Kuo-Chin 
Published: September 2020

Abstract
Background: The Kocher-Langenbeck (K-L) approach is the standard method for the treatment of posterior wall or column acetabular fractures. This approach allows direct access to the posterior structures of the acetabulum, but is limited cranially and caudally by the neurovascular bundle. The present study was conducted to assess the quality of reduction and the incidence of complications in patients who underwent the modified “one-incision two-window” K-L approach.Methods : This is a Retrospective case series with recruited thirteen consecutive patients from 2015 to 2017 who sustained an acute, displaced posterior wall or column acetabular fracture. All patients were treated with modified “one-incision two-window” K-L approach.Results: The mean operation time, mean intraoperative blood loss, and mean incision wound length were estimated to be 103.8 min (60-120 min), 373.1 mL (100-700 mL), and 9.7 cm (8.0-13.0 cm), respectively. The radiographic quality of reduction was graded as anatomical reduction (maximum residual displacement [MRD] ≤ 2 mm) in all cases, according to Matta’s criteria. Concerning the incidence of complications, there were no iatrogenic neurovascular injury, no surgical site infections, and no osteonecrosis of the femoral head or heterotopic ossification in this cohort. One patient with transverse posterior wall fracture (group 1) experienced deep vein thrombosis in the lesion leg. Another two patients with solitary posterior wall fracture (group 2) developed posttraumatic osteoarthritis, with one diagnosed as Tonnis grade I lesion and the other as Tonnis grade III lesion. With respect to the clinical treatment outcome, the mean visual analogue scale (VAS), mean modified Harris Hip Score (mHHS) and subjective satisfaction rate were 1.7 (1.0-2.0), 90.6 (81-100), and 84.6% (80%-90%), respectively. Although there was no significant difference in the satisfaction rate (82.9% vs. 87.0%, P = 0.941) at 12 months after surgery, group 1 patients had more increased VAS score (2.0 vs. 1.2, P = 0.016) and more decreased mHHS (87.7 vs. 94.6, P = 0.014) than group 2 patients. Conclusions: Our pilot study confirmed that the “one-incision two-window” K-L approach is a simple, safe, reliable, and effective way to manage acute, displaced posterior wall or column acetabular fractures.Level of evidence: Therapeutic study, level IV.
A Novel Neutralizing Antibody Targeting Receptor Binding Domain of SARS-CoV-2
Authors: Lee Soo-Young , Kim Cheolmin , Ryu Dong-Kyun , Lee Jihun , Kim Young-Il , Seo Ji-Min , kim Yeon-Gil , Jeong Jae-Hee , Kim Minsoo , Kim Jong-In , Kim Pankyeom , Bae Jin Soo , Shim Eun Yeong , Lee Min Seob , Kim Man Su , Noh Hanmi , Park Geun-Soo , Park Jae Sang , Son Dain , An Yongjin , Lee Jeong No , Kwon Ki-Sung , Lee Joo-Yeon , Lee Hansaem , Yang Jeong-Sun , Kim Kyung-Chang , Kim Sung Soon , Woo Hye-Min , Kim Jun-Won , Park Man-Seong , Yu Kwang-Min , Kim Se-Mi , Kim Eun-Ha , Park Su-Jin , Jeong Seong Tae , Yu Chi Ho , Song Youngjo , Gu Se Hun , Oh Hanseul , Koo Bon-Sang , Hong Jung Joo , Ryu Choong-Min , Park Wan Beom , Oh Myoung-don , Choi Young Ki 
Published: September 2020

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the current COVID-19 global pandemic. Vaccines and therapeutics are urgently needed for this highly transmissible virus. In this study, we screened human monoclonal antibodies (mAbs) targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein from an antibody library constructed from peripheral blood mononuclear cells of a COVID-19 convalescent patient. A potent neutralizing antibody, termed CT-P59, was identified and found to be effective against various SARS-CoV-2 isolates including the D614G spike protein variant without antibody-dependent enhancement effect. Complex crystal structure of CT-P59 Fab/SARS-CoV-2 RBD showed that CT-P59 blocks interaction regions of SARS-CoV-2 RBD for its cellular receptor, angiotensin converting enzyme 2 (ACE2). The binding orientation of CT-P59 is notably different from the previously reported neutralizing mAbs targeting SARS-CoV-2 RBD suggesting that CT-P59 can be a novel binder to SARS-CoV-2 RBD. Therapeutic effects of CT-P59 were evaluated in three animal models (ferret, hamster, and rhesus monkey), and a substantial reduction in viral titre along with alleviation of clinical symptoms was observed. These findings suggest that the human monoclonal antibody, CT-P59, is a promising therapeutic candidate for treatment of COVID-19.
Interfaces of Occupational Health Management and Corporate Social Responsibility: A multi-Centre Qualitative Study from Germany
Authors: Kuhn Eva , Müller Sebastian , Teusch Christoph-Daniel , Tanner Grit , Schümann Marlies , Baur Carolin , Bamberg Eva , Heidbrink Ludger , McLennan Stuart , Buyx Alena 
Published: September 2020

Abstract
Background: The workplace has been identified as a priority setting for health promotion. There are potential advantages of systematically integrating Occupational Health Management (OHM) and Corporate Social Responsibility (CSR). However, OHM and CSR are usually overseen by different management branches with different sets of values, and there is a lack of empirical research regarding interfaces between OHM and CSR. Germany offers a particularly useful setting due to legislation requiring health to be promoted in the workplace. This study aims to examine key stakeholders’ views and experiences regarding interfaces between OHM and CSR in German companies. Methods: Individual semi-structured qualitative interviews were conducted with a sample of 77 German stakeholders from three different groups: experts in occupational health and corporate social responsibility from various companies (n=35), business partners (n=19) and various non-business partners (n=23). Transcripts were analysed using qualitative content analysis. Results: Participants identified several areas in which OHM and CSR are already interacting at strategic, structural and cultural levels, but has also highlighted several barriers that undermine a more meaningful interaction. Participants reported difficulties in articulating the underlying ethical values that are relevant to both OHM and CSR at the strategic level. Several structural barriers were also highlighted, including a lack of resources (both financial and knowledge), and OHM and CSR departments not being fully developed or being undertaken at entirely different operational levels. Finally, the missing practical implementation of corporate philosophy was identified as a key cultural barrier to interfaces between OHM and CSR, with existing guidelines and companies’ philosophies that already connect OHM and CSR not being embraced by employees and managers.Conclusions: There is already significant overlap in the focus of OHM and CSR, at the structural, strategic and cultural levels in many German companies. The potential is there, both in theory and practice, for the systematic combination of OHM and CSR. The insights from this study will be useful to ensure that closer integration between both management branches are set up in a socially sustainable and ethical manner.
The Effect of Psycho-education Program on Resilience in the Caregivers of Clients with Bipolar Disorder
Authors: Khalifi Talieh , Bahrami Raheleh 
Published: September 2020

Abstract
BACKGROUND: Resilience in family refers to the flexible and developed behavioral pattern in the caregivers of clients with mental disorders that face challenges during the caring process. The aim of this study was to investigate the effect of psychoeducation program on resilience in the caregivers of clients with bipolar disorder. METHODS: This is a quasi-experimental study with a control and an experimental group. The participants of the study were 64 caregivers of clients with bipolar disorder in Sanandaj. The experimental group received the intervention for 4 weeks. The control group did not receive any intervention. The instrument of this study included a demographic questionnaire and a Connor-Davidson (CD-RISC) Resilience Scale. The data analysis was performed using descriptive statistics (frequency, percentage, mean and standard deviation) and inferential statistics (independent t-test, paired t-test and repeated measures analysis of variance) using SPSS-22 software. RESULTS: The results showed that there is no difference between the experimental and control groups in terms of the distribution of contextual variables. There was no statistically significant difference between the mean and standard deviation of the resilience score before the intervention in the control group and in the experimental group (P = 0.059). However, after the intervention, the difference was statistically significant (P <0.001) and showed an increase in the experimental group. CONCLUSION: This Quasi-experimental study indicates that psychoeducation is an effective way for the resilience in the caregivers of clients with bipolar disorder and it can be promote resilience in the caregivers.
Comparison of Loop-Mediated Isothermal Amplification and conventional PCR for Diagnosis of common Brucella species
Authors: Moeini-Zanjani Ali , Pournajaf Abazar , Ferdosi-Shahandashti Elaheh , Gholami Mehrdad , Masjedian Faramarz , Khafri Soraya , Rajabnia Ramazan 
Published: September 2020

Abstract
Objective: Rapid, reliable, and affordable detection of Brucella species via the molecular methods remains a challenge. In recent years, loop-mediated isothermal amplification (LAMP) is a functional nucleic acid amplification technique offering a substitute to polymerase chain reaction (PCR). So, we compared the LAMP assay with the conventional PCR for the identification of common Brucella species in Iran. In this study, LAMP assay was comprehensively evaluated against the common PCR method. A group of specific LAMP primers were used to amplify a highly specific fragment from the sequence of the Brucella abortus BCSP31 gene. Sensitivity and specificity values of tests were done with a set of 78 (50 Brucella and 28 non-Brucella) strains. Results: A dilution series of Brucella abortus DNA indicated that the LAMP reaction could reliably detect 10 (fg/µl) DNA target copies per reaction within 36 minute, which is 10 times greater than the PCR assay. In summary, we conclude that LAMP assay provide accurate and fast test results to identify of common Brucella species in low-complexity labs, mainly in low and lower middle income countries.
Admission Exam and Preparatory Year Scores’ Association with Performance in Basic Science Courses in Health Science Colleges
Authors: Alamoudi Aliaa Amr , Falattah Hind Ibrahim , Eldakhakhny Basmah Medhat , kamel Fatemah Omar , AlSawwa Lana Adey , Elsamanoudy Ayman Zaky 
Published: September 2020

Abstract
Background: In King Abdulaziz University, medical and health science schools depend on admission exams (Aptitude and Achievement) and Preparatory year scores in their students’ selection. However, with the growing number of applicants and the drastic changes in teaching and assessment in these colleges continuous assessment and development of admission criteria are needed. In this study, we aimed to evaluate the correlation of admission exam scores, in addition to the Preparatory year GPA, with academic performance in the basic science subjects such as Clinical Biochemistry and Clinical Pharmacology in health science colleges.Methods: The study was conducted on four cohort studies, two faculty of nursing cohorts; Nursing students (2017-2018,n=146) Nursing students (2018-2019,n=81), and two faculty of applied medical sciences cohorts, C.Nutrition students (2017-2018,n=33), C.Nutrition students (2018-2019,n=28) .The students’ scores of GAT, SAAT, and preparatory year GPA were all recorded at the beginning of each semester before the beginning of courses. Clinical Biochemistry and Clinical Pharmacology exam results were recorded at the end of the semester. Correlation was done for each cohort and all cohorts pooled. Results: Results showed that there was no significant correlation between admission exams scores and the students ‘academic achievement in Clinical Pharmacology, and with only a weak correlation detected between SAAT and the overall achievement in Clinical Biochemistry ( r= 0.192*, P= 0.042) in Nursing students (2017-2018). On the other hand Clinical Pharmacology exam results showed a significant positive correlation with Clinical Biochemistry results (r=0.688, P=0.000). Conclusion: Our results could indicate the need to revisit the admission criteria for these colleges. Furthermore, specific preparatory year tracks for health science colleges can ensure that students improve the specific skills and knowledge required for their future college years.