bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intervention und Operation unter antithrombotischer Therapie & Antikoagulation
Authors: Hermesmeier Jonas , Gonska Bernd-Dieter 
Published: March 2020

ZUSAMMENFASSUNGDer richtige periinterventionelle Umgang mit Patienten, die unter einer Dauertherapie mit Blutverdünnern stehen, ist wichtig und wird in Zukunft an Bedeutung gewinnen. Von der Abwägung der Risiken einer Unterbrechung oder Fortführung der Medikamenteneinnahme, über die Überbrückung mit Heparin bis hin zum korrekten zeitlichen Ablauf müssen eine Vielzahl an Faktoren für jeden Patienten individuell beachtet werden.Durch die steigende Lebenserwartung nimmt die Anzahl an Patienten zu, die einer dauerhaften Antikoagulation oder Thrombozytenaggregationshemmung bedürfen. Gleichzeitig steigt die Zeit, die diese mit einer solchen Therapie leben. Die zugrundeliegenden Erkrankungen stellen selten eine Kontraindikation für andere Eingriffe dar und so bedürfen mehr und mehr solcher Patienten einer Operation oder Intervention. Der richtige periinterventionelle Umgang mit Patienten unter Dauertherapie mit Blutverdünnung ist wichtig und wird in Zukunft noch an Bedeutung gewinnen. Dieses Thema betrifft alle operativ oder interventionell Tätigen wie auch die mitbetreuenden Ärzte. In Bezug auf die korrekte Vorgehensweise besteht weiterhin eine lebhafte Forschungsaktivität, doch auch unabhängig von einzelnen Substanzen sind zuletzt Behandlungsparadigmen in Bewegung gekommen.
Radiographic Prognostic Factors Relevant to Surgical Outcomes of Arthroscopic Partial Medial Meniscectomy in Elderly Patients with Mild Osteoarthritis
Authors: Park Sang Hoon , Choi Chong Hyuk , Yoo Ju Hyung , Kim Sung Hwan , Yoon Han Kook , Jung Min , Choi Ki Hong , Moon Hyun Soo 
Published: March 2020

AbstractThe aim of this study was to investigate radiographic factors relevant to predict surgical outcomes of arthroscopic partial meniscectomy (APM) in elderly patients with mild osteoarthritis (Kellgren–Lawrence grades 1 and 2). Data of 172 consecutive patients aged >70 years who underwent arthroscopic meniscal surgery were reviewed retrospectively. The patients who met the inclusion criteria were classified into two groups based on the minimal clinically important difference value of the Lysholm knee scoring scale comparing the score of the last visit with that of the preoperative period: group 1 (with clinically significant improvement) and group 2 (without clinically important change). Radiographic factors assessed on X-ray and magnetic resonance images were evaluated using bivariate and logistic regression analyses. A total of 73 patients were included in this study. Bivariate analysis revealed that the extent of meniscus extrusion (p = 0.031), meniscus extrusion ratio (p = 0.001), and grade of meniscus degeneration (p = 0.019) were significantly different between the groups. Multivariate logistic regression analysis showed that the meniscus extrusion ratio was the most important independent predictive factor for surgical outcomes with clinically important changes (coefficient = 0.159, p = 0.009). On receiver operating characteristic (ROC) curve analysis, the cutoff point of the meniscus extrusion ratio discriminating the two groups was 34.2% (sensitivity: 79.3%; specificity: 68.6%; accuracy: 72.6%). Meniscus extrusion ratio was the most relevant predictive factor for discriminating patients with clinically important change. Meniscus extrusion ratio, with the cutoff point of 34.2%, could serve as a guide to determine whether to perform APM in elderly patients with mild osteoarthritis. This is a Level IV, therapeutic case series study.
Antiphosphatidylserine/Prothrombin Antibodies: An Update on Their Association with Clinical Manifestations of Antiphospholipid Syndrome
Authors: Radin Massimo , Foddai Silvia G. , Cecchi Irene , Rubini Elena , Schreiber Karen , Roccatello Dario , Bertolaccini Maria Laura , Sciascia Savino 
Published: March 2020

Abstract
Objective The aim of the study is to perform a systematic review on the recent available evidence on antiphosphatidylserine/prothrombin (aPS/PT) antibodies and their association with clinical manifestations of the antiphospholipid syndrome (APS).
Methods A detailed literature search was applied a priori to Ovid MEDLINE, In-Process and Other Non-Indexed Citation 2012 to present and to abstract from EULAR and ACR/ARHP Annual Meetings (2012–2019).
Results Data from 2,901 patients, 587 diseases controls and 559 healthy controls included in 15 retrieved studies was analyzed. The patient population included 1,219 patients classified as APS according to the Sidney criteria, 285 patients with isolated persistently positive antiphospholipid antibodies (aPL) and 1,397 patients with a clinical suspicion of APS. Twelve studies, including 1,888 patients, analyzed the association between aPS/PT antibodies and thrombosis. We observed a statistically significant association between aPS/PT IgG/IgM positivity and thrombotic events (mean odds ratio [OR]: 6.8 [95% CI: 3.18–16.4], p < 0.05), confirmed when analyzing aPS/PT IgG (mean OR: 6.7 [95% CI: 3.04–21.6], p < 0.05) and aPS/PT IgM (mean OR: 4.35 [95% CI: 1.54–17.77], p < 0.05) separately. Seven studies, including 1,388 patients, evaluated the association between aPS/PT antibodies and PM. When pooled together, we found a statistically significant association between any PM and aPS/PT IgG/IgM positivity (mean OR: 10.6 [95% CI: 3.54–35.38], p < 0.05), particularly aPS/PT IgG positivity (mean OR: 6.7 [95% CI: 3.04–21.6], p < 0.05).
Conclusion Our results highlight the strong association between aPS/PT and the clinical manifestations of APS. With the available level of evidence, aPS/PT testing can be considered as a robust test applicable in the investigation of patients suspected for APS, also beyond the research settings.
Long-Term Safety and Efficacy of Recombinant Coagulation Factor IX Albumin Fusion Protein (rIX-FP) in Previously Treated Pediatric Patients with Hemophilia B: Results from a Phase 3b Extension Study
Authors: Kenet Gili , Chambost Hervé , Male Christoph , Halimeh Susan , Lambert Thierry , Li Yanyan , Seifert Wilfried , Santagostino Elena 
Published: March 2020

Abstract
Introduction A phase 3b extension study evaluated the long-term safety and efficacy of a recombinant fusion protein-linking coagulation factor IX (FIX) with albumin (rIX-FP) for the routine prophylaxis and on-demand treatment of bleeding in pediatric hemophilia B patients.
Methods Previously treated patients aged <12 years with moderate to severe hemophilia B enrolled in a 3-year extension study following a phase 3 pivotal study in which they received weekly rIX-FP prophylaxis. In the extension study, they could maintain or extend their prophylaxis interval to every 10 or 14 days if they were well controlled on the 7-day regimen.
Results Compared with their initial regimen, by the end of the study, dosing intervals were the same, extended, and shortened in 16, 4, and 4 patients, respectively. Very low annualized spontaneous bleeding rates (AsBRs) were observed; median AsBR was 0.0 for the 7- and 10-day regimens, and 1.1 for the 14-day regimen. The 7- and 14-day regimens were comparable in preventing spontaneous bleeds; mean (95% confidence interval) difference in AsBR of −1.2 (−2.6 to 0.3) bleeding episodes/year/subject. Overall, 96% of bleeding episodes were successfully treated with one or two injections of rIX-FP. Patients on a 14-day regimen maintained a mean steady-state trough FIX level of >7.2 IU/dL. No patient developed an inhibitor.
Conclusion This extension study demonstrated the long-term safety and efficacy of weekly rIX-FP in pediatric patients. Additionally, it showed that adequate bleed protection can be achieved with 10- or 14-day rIX-FP regimens in selected pediatric patients while maintaining safety.
Syntax of causative-passive correlation from a cross-linguistic perspective
Authors: Hu Xiaoshi 
Published: March 2020

Abstract
Causatives and passives are two different types of syntactic constructions, but their interaction can be observed cross-linguistically. By investigating the causative-passive correlation in Chinese, English and French, we try to offer an appropriate account for the causative-passive correlation by specifying its necessary conditions. We argue that the constructions which involve the causative-passive correlation must be mono-phasal, and the embedded object can be co-referred to the matrix subject by syntactic movement.
On the scope of quantifier phrases in Chinese passive construction
Authors: Yang Xiaolong , Wu Yicheng 
Published: March 2020

AbstractQuantifier phrases (QP) can co-occur in a single sentence, which may cause ambiguity in terms of scope relation, viz. wide scope and narrow scope interpretations.Aoun & Li (1993)claim that quantifier scope ambiguity also exists in Chinese passive construction, such asyige nűren bei meige ren ma‘a woman was scolded by everyone’. FollowingLee (1986)’s proposal, it is argued in this paper that the scopal relations of Chinese QPs are not purely syntactic as in Aoun & Li’s analysis, but should be determined by the interaction between syntax, semantics, and pragmatics. Based on naturalistic data, it is shown that (i) Chinese QPs can be classified into whQP, distributive-universal QP and group-denoting QP, whose semantic properties determine the scope relations between them; (ii) in general, a QP is devoid of referentiality, yet it can acquire referentiality depending on its co-occurrence with other QPs or contextual factors; (iii) the subject definiteness constraint in Chinese, a language-specific constraint, would affect the interpretation of subject QPs in Chinese passive construction.
Biosorption of sterols from tobacco waste extract using living and dead of newly isolated fungus Aspergillus fumigatus strain LSD-1
Authors: Liu Fang , Zhang Xiaoping , Wang Mingdao , Guo Lele , Yang Yingyue , Zhao Mingqin 
Published: March 2020

Abstract
Sterols are verified to be able to produce polycyclic aromatic hydrocarbons during its pyrolysis. In this study, a kind of Aspergillus fumigatus (LSD-1) was isolated from cigar leaves, and the biosorption effects on the stigmasterol, β-sitosterol, campesterol, cholesterol, and ergosterol by using living and dead biomass of LSD-1 were investigated. The results showed that both living and dead biomass could efficiently remove these sterols in aqueous solution and tobacco waste extract (TWE). Interestingly, compared with the living biomass of LSD-1, the dead biomass of LSD-1 not only kept a high adsorption efficiency but also did not produce ergosterol. Overall, dead biomass of LSD-1 was a more suitable biosorbent to sterols in TWE. Furthermore, Brunner-Emmet-Teller (BET), Fourier transformed infrared spectrometer (FTIR) and scanning electron microscope (SEM) analysis were used to explore the biosorption process of living and dead biomass and their differences, suggesting that the biosorption of sterols was a physical process.
Nanomaterials by design: a review of nanoscale metallic multilayers
Authors: Sáenz-Trevizo A , Hodge A M 
Published: March 2020

Abstract
Nanoscale metallic multilayers have been shown to have a wide range of outstanding properties, which differ to a great extent from those observed in monolithic films. Their exceptional properties are mainly associated with the large number of interfaces and the nanoscale layer thicknesses. Many studies have investigated these materials focusing on magnetic, mechanical, optical, or radiation tolerance properties. Thus, this review provides a summary of the findings in each area, including a description of the general attributes, the adopted synthesis methods and most common characterization techniques used. This information is followed by a compendium of the material properties and a brief discussion of related experimental data, as well as existing and promising applications. Other phenomena of interest, including thermal stability studies, self-propagating reactions and the progression from nano multilayers to amorphous and/or crystalline alloys, are also covered. In general, this review highlights the use of nano multilayer architectures as viable routes to overcome the challenges of designing and implementing new engineering materials at the nanoscale.
The Improvement of Teacher Competency Makes Expansion Learning Media through Model Workshops Modeling, Modification and Creativity
Authors: Simbolon R , Saragih A H , Situmorang J 
Published: March 2020

Abstract
Teachers in Middle School Sub Rayon 23 Medan still has low competence in making learning media. The creative ideas from the science teacher have not yet emerged, the teacher’s understanding of making the learning media expansion is still minimal, the teacher has not been motivated to make the media curiosity about the media is still low. This study aims to find out how to improve teacher competencies in making science learning media, especially expansion. The action hypothesis in this study is the teacher’s competence in making science learning media possible improved through workshops. The subjects of the study were 9 people of Natural Sciences at Sub Rayon 23 Junior High School in Medan. The object of research is learning media especially expansion. Media Learning IPA is Swelling Solids of goods secondhand or materials that price it cheap so it can be affordable. The results of the data analysis makes learning media Expansion Solids in cycle 1 at 29.33 (Less), Cycle 2 at 64.00 (Good), and meeting 3 at 84.89 (Very good). Increase in the average value of teacher competence: 84.89%-29.33% = 55.56%. The results of the questionnaire analysis showed that 95.00% of the science teachers of the Sub- Rayon 23 Junior High School in Medan strongly agreed to make the learning media for Solid Substance Expansion through workshops conducted by researchers because of their increased competence.
Development of a blended learning model using the online learning system (SIPDA), Universitas Negeri Medan
Authors: Siregar N , Manurung S L 
Published: March 2020

Abstract
This study aims to produce a model of blended learning that is assisted by an Universitas Negeri Medan (Unimed) online learning system (SIPDA) that is valid, practical, and effective. The stages of developing a SIPDA-assisted Blended learning model consist of (1) preliminary stages, (2) prototyping stages, which include planning, evaluation, and revision, and (3) product assessment stages. The quality of the SIPDA-based Blended learning model refers to the quality criteria, according to Nieveen, which includes valid and practical measures. The study conducted at Unimed in the sixth-semester students of Mathematics Education Study Program. The instruments in this study consisted of (1) the validity assessment instruments of the component models and learning support tools, (2) the practical assessment instruments of lecturers and students. The results showed that the SIPDA-based blended learning model that included the syntax/steps of learning, social systems, reaction principles, support systems, and instructional and supportive impacts, along with learning support tools, had met valid and practical criteria.
The use of Mixed Apps as accommodation of mathematical student creativity
Authors: Andriani A , Sagala P N 
Published: March 2020

Abstract

Mixed Apps is a mixture of 3 information and communication technology applications, Web applications, Google classroom applications, and hang out applications. The web application was a place for lecturers and students to share learning material; the google classroom application was for task collection while the hangout was for video conferences. In general, this research was conducted to improve the quality of the process and learning outcomes further, especially in mathematics teaching and learning strategy courses. The specific purpose of this study is to describe the effect of using Mixed Apps on the creativity of Mathematics Education students. This research method is mixed research, a mixture of qualitative methods, and quantitative methods. This research i at a university in Medan city with 30 students. The research instruments were interview items, student creativity products, creativity product assessment sheets and student questionnaire responses. As for learning by utilizing Mixed apps, some students have high creativity scores of 20 students, five students who are of moderate value, and five who fall into the low category. But overall, 87% of students have a positive (happy) response to learning by using Mixed Apps.
Perception of Biology Student Universitas Negeri Medan towards Biology Cell Learning Based on E-Learning
Authors: Gaol A Y L , Sipahutar H 
Published: March 2020

Abstract
The purpose of this research is to know the students’ perceptions of learning biology cell based on e-learning. This descriptive research was done by questionnaire in collecting the data. The source of the data was students of biology of FMIPA Unimed class of 2018. Based on the questioners that have been analyzed, 80,76% students feel that e-learning support them in learning teaching process and 96,15% argue that e-learning can help them to access subject matter. But 50% students face some problems to interact, not only with other students but also with lecturer. Further research is needed to develop e-learning content in biology cell to make it easier for students to understand and to improve the interaction between student and lecturer in e-learning.
The Development of Teaching Material of Physics Introductory for Biology with Science, Technology, Engineering, and Mathematics (STEM) Approach
Authors: Rangkuti Muhammad Aswin , Ritonga Winsyahputra , Brata Wasis Wuyung Wisnu 
Published: March 2020

Abstract
In higher education, many concepts in physics are applied in various disciplines that explain the development of the theory they learn; one of them is Physics Introductory. Natural Science Students, such as Biology and Chemistry, unwittingly use many essential concepts of Physics. However, the learning process in this course generally only explains concepts in Physics without relating them to the needs of interdisciplinary knowledge. As a result, interdisciplinary students feel that Physics is meaningless and not applicable. This raises the perception that causes them not interested to learn Physics. In fact, the concepts contained in this course are very important for the development of their knowledge. This research will try to rearrange the materials in the Physics introductory course linked to the Biology concepts. The development of teaching materials uses the Research and Development (R & D) method. This paper will discuss theories and publications that support the importance of interdisciplinary integrated learning. Furthermore, the development of teaching material and its effectiveness will be discussed in our future publication.
Implementation Of Textbook That Integrates KKNI 6 Task Improving Student Mathematical Communication Ability.
Authors: Manurung SL , Elfitra  , Simorangkir M 
Published: March 2020

Abstract
The purposes of this study were: first to determine the mathematical communication ability differences between students who learned with textbook that integrates 6 task KKNI and students who learned without using textbooks that integrated 6 task KKNI; second to describe the interaction between the application of textbook integrates 6 task KKNI with students’ mathematics prior knowledge.. This study is semi-experimental research. DIK class D-Mat 2019 and the class F-MAT DIK 2019 were randomly selected as consecutively the control class and the experimental class. The instrument used for this study took place, namely mathematical communication ability test and observation sheet. Data was analyzed using ANOVA analysis and ANACOVA. The results showed that, the first class of students communication skills mathematical experiment better than the students who are in the control class. Second, there is no interaction between the application of integrated textbook 6 KKNI task and beginning math ability of students to students mathematical communication.
Comparative of prim’s and boruvka’s algorithm to solve minimum spanning tree problems
Authors: Marpaung F , Arnita  
Published: March 2020

Abstract
Optimization is important in an algorithm. It can save the operational costs of an activity. In the Minimum Spanning Tree, the goal is to achieve how all vertices are connected with the smallest weights. Several algorithms can calculate the use of weights in this graph. The purpose of this study is to find out the Primary electricity distribution network graph model and correct algorithm to determine the minimum spanning tree. By comparing two algorithms, Prim’s and Boruvka’s algorithm, it will get an efficient algorithm to solve the minimum spanning tree problem. To get the output it takes several steps: Data collection: Designing Model: calculating the minimum spanning tree of Prim’s algorithm, the Boruvka’s algorithm: Comparing the efficiency of each algorithms. The analysis shows that the Prim’s and Boruvka’s algorithm have different steps even though the final result in the form of weights obtained in achieving the minimum spanning tree is the same. But in the case of electric network optimization, the Prim’s algorithm is more efficient.
Study of thermodynamics and complex structures on spin transitions of [Fe2(Htrz)6(trz)3]Cl and [Fe4(Htrz)10(trz)5]Cl3 complexes using the Density Functional Theory method
Authors: Nugraha A W , Jahro I S , Onggo D , Martoprawiro M A 
Published: March 2020

Abstract
The complex of iron(II) 1,2,4 H-triazole chloride is a complex that has spin transition characteristics. Thermodynamic studies and determination of changes in complex structured data have been carried out on the [Fe2(Htrz)6(trz)3]Cl and [Fe4(Htrz)10(trz)5]Cl3 complexes with the DFT method. The iron(II) 1,2,4 H-triazole chloride complex has a polymeric structure, so in this study used a model with 2 and 4 Fe(II) ions. The computational chemistry study using a hybrid functional/basis set B3LYP/6-31G(d). The results obtained show the distance between the Fe(II) ions, the bond length of Fe-N, and the distance between the Fe(II) ions with Cl− in the [Fe2(Htrz)6(trz)3]Cl complex at low spin states respectively 3.717Å, 1.990Å-2.049Å, and 6.829Å, while in the high spin state respectively 3.932Å, 2.130Å-2.360Å and 7,050Å. The distance between the Fe(II) ions, the bond length of Fe-N, and the distance between the Fe(II) ions with Cl− in the [Fe4(Htrz)10(trz)5]Cl3 complex at low spin states respectively 3.661Å-3.681Å, 1.960Å-2.089Å and 5.037Å, while in the high spin state respectively 3.911Å-3.946Å, 2.092Å-2.367Å and 5.280Å. Thermodynamic data in [Fe2(Htrz)6(trz)3]Cl complex is ∆E=-24.38989kJ/Mol, ∆H=-24.3909kJ/Mol, ∆G=-47.9364kJ/Mol, and ∆S=0.0789kJ/Mol. Thermodynamic data of [Fe4(Htrz)10(trz)5]Cl3 complex is ∆E=-12.8564kJ/Mol, ∆H=-12.8564kJ/Mol, ∆G=-33.6445kJ/Mol, and ∆S=0.0697kJ/Mol. The structure and thermodynamic data are compatible with experimental measurement data in the laboratory.