bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Tan/Chen/Yang Synthesis of Schindilactone A
Authors: Taber Douglass F. 
Published: November 2020

Schindilactone A 3 is one of a closely related family of polycyclic lactones that have been used in China for the treatment of rheumatic disease. The synthesis of 3 reported (Angew. Chem. Int. Ed. 2011, 50, 7373) by Ye-Feng Tang of Tsinghua University and Jia-Hua Chen and Zhen Yang of Peking University is an elegant tour of metal-mediated bond construction, as exemplified by the cyclization of 1 to 2. The preparation of 1 began with the Diels-Alder reaction of 4 with the butadiene 5. Addition of methyl magnesium chloride converted 6 to the crystalline lactone 7. Angular hydroxylation followed by ring expansion gave the bromo enone 8, which was homologated to the lactone 11. Apparently, the bulky silyloxy group directed the addition of the butenyl Grignard reagent 10 to the top face of the ketone carbonyl. Hydroxylation of the lactone followed by the addition of 12 then gave 1 as a mixture of diastereomers. Only one of the two diastereomers of 1 could undergo ring-closing metathesis to form the second of the three carbocyclic rings of 3. The two lactol diastereomers were in equilibrium with each other by way of the open-chain enone. When MgBr2 was added to encourage equilibration, the metathesis proceeded to completion to give 2. The tertiary alcohol of 2 was esterified with 2-butynoic acid to give 13. Intramolecular Pauson-Khand cyclization, using the optimized protocol developed by the authors, then delivered the enone 13, completing the last carbocyclic ring of 3. The last remarkable metal-mediated reaction in the synthesis was the oxidative carbonylation of 14 to 15. It is not clear if the postcarbonylation event is direct Pd-mediated C–O bond formation or the intramolecular addition of alkoxide to a transient butenolide. To complete the synthesis, 15 was methylated, then deprotonated and kinetically quenched to set the proper relative configuration of the last methyl group. Remarkably, despite the presence in the molecule of three other acidic protons, including the one that had just been removed and kinetically reset, exposure of the acetate 16 to a large excess of base, followed by oxidation, gave clean conversion to schindilactone A 3.
The Meaning of Life
Authors: Rosenstein Donald L. , Yopp Justin M. 
Published: November 2020

Not long after Susan died, Karl traveled to Connecticut to attend a wedding. He anticipated some uncomfortable moments but made it through the ceremony without feeling too sad. The reception was much more difficult. Karl was sitting alone and nursing a drink when the deejay announced: . . . Listen up everybody. I need all the married couples to come out on the dance floor. . . . A dozen or so couples came forward as the deejay explained the rules. . . .I want everyone to keep dancing until I call out the number of years that you’ve been married. Let’s start with an easy one: take a seat if you’ve been married for less than four hours. . . . The smiling bride and groom walked off the dance floor as their guests laughed and applauded. . . . Now, keep dancing if you’ve been married for five years or longer. . . . Several young couples took their seats. . . . Ten years … fifteen years. . . . Karl’s heart sank. He and Susan would never reach that milestone. Their number, 14, was frozen in time. The contest ended when an elderly couple who had been married for more than fifty years were the only dancers remaining. As the guests stood and clapped, Karl sat in silence and scanned the room. The contest winners were on a victory lap of hugs and high-fives. The newlyweds stood to the side of the dance floor staring deeply into each other’s eyes. Karl was alone and Susan was dead. Nothing about this celebration felt relevant to him. The focus of group meetings continued to evolve. In the beginning, the group was mostly a safe place for the fathers to share their grief and feel less alone. It quickly became a practical problem-solving get-together and over time matured into a forum to experiment with personal reinvention. The men and their children had experienced staggering pain that often struck them as completely meaningless. They related to Karl’s experience at the wedding in that they also often felt alone, disconnected, and fundamentally confused about their new place in the world and whether it even mattered.
Undecidability and Recursive Inseparability
Authors: Smullyan Raymond M 
Published: November 2020

Abstract
§1. Some Preliminary Theorems. we continue to let S be an arbitrary system, P be the set of Gödel numbers of the provable formulas of S and R be the set of Gödel numbers of the refutable formulas of S. Theorem 1. The set P̃* is not representable in S. Proof. This is the diagonal argument all over again. If H(v1) represents P̃* and h is the Gödel number of H(v1), the H[h̅] is provable in S iff h Ï p* iff d(h) ÏP iff H[h̅] is not provable in S, which is a contradiction. Theorem 1.1. If S is consistent, then P* is not definable in S. Proof. Suppose P* is definable in S. If S were consistent, then P* would be completely representable in S (cf. §3.1, Ch. 0). Hence P̃* would be representable in S, contrary to Theorem 1. Therefore, if S is consistent, then P* is not definable in S. Theorem 1.2. If the diagonal function d(x) is strongly definable in S and S is consistent, then P is not definable in S. Proof. Suppose d(x) is strongly definable in S. Since P* = d -1(P), then if P were definable in S, P* would be definable in S (by Th. 11.2, Ch. 0). Hence S would be inconsistent by Theorem 1.1. Exercise 1. Show that if S is consistent, then R* is not definable in S. Exercise 2. Show that if S is consistent, then no superset of R* disjoint from P* is definable in S, and no superset of P* disjoint from R* is definable in S. Exercise 3. Prove that if S is consistent and if the diagonal function is strongly definable in S, then no superset of P disjoint from R is definable in S. [This is stronger than Theorem 1.2.] §2. Undecidable Systems. A system S is said to be decidable (or to admit of a decision procedure) if the set P of Gödel numbers of the provable formulas of S is a recursive set. It is undecidable if P is not recursive. This meaning of ‘undecidable’ should not be confused with the meaning of ‘undecidable’ when applied to a particular formula (as being undecidable in a given system S).
Chemorheology of Thermosets
Authors: Han Chang Dae 
Published: November 2020

Abstract
Thermosets (e.g., unsaturated polyester, epoxy, urethane) are small molecules containing functional groups, which undergo chemical reactions (commonly referred to as “cure”) in the presence of an initiator(s) or a catalyst(s). In a broader sense, thermosets can be regarded as being parts of reactive polymer systems, which include pairs of polymers (e.g., blends of maleated polyolefin and nylon 6, as presented in Chapter 11) that undergo chemical reactions during compounding, and mixtures of an elastomer and a vulcanizing agent that undergo cross-link reactions (commonly referred to as vulcanization) at an elevated temperature. The subject of investigating the rheological behavior of reactive polymer systems is referred to as “chemorheology.” Since chemorheology is such a very broad field of investigation, one must specify the polymer system under consideration, classifying as chemorheology of thermosets, chemorheology of reactive polymer blends, chemorheology of elastomer vulcanization, and so on. In this chapter, for a number of reasons we restrict our presentation to the chemorheology of thermosets only. These reasons include (1) the limited space available here, meaning that it is not possible to present the chemorheology of every reactive polymer system, (2) thermosets play a very important role in polymer processing from an industrial point of view, and (3) the presentation of the chemorheology of thermosets in this chapter lays the foundation for the presentation of processing of thermosets in Chapters 11–13 of Volume 2. In the 1970s and 1980s, considerable amounts of effort were spent on investigating the chemorheology of thermosets. There are many experimental techniques that have been used to investigate the cure kinetics of thermosets: differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, dielectric measurements, and rheokinetic measurements. There are monographs (Kock 1977; May 1983; Turi 1981) and a comprehensive review article (Halley and Mackay 1996) on the subject. A better understanding of the chemorheology of thermosets requires an understanding of the kinetics of chemical reactions during cure. It can then easily be surmised that an understanding of the chemorheology of thermosets is much more complex than the rheology of thermoplastics presented in Chapter 6 through Chapter 12.
The Chemical Basis of Morphogenesis (1952)
Authors: Turing Alan 
Published: November 2020

Abstract
It is suggested that a system of chemical substances, called morphogens, reacting together and diffusing through a tissue, is adequate to account for the main phenomena of morphogenesis. Such a system, although it may originally be quite homogenous, may later develop a pattern or structure due to an instability of the homogeneous equilibrium, which is triggered off by random disturbances. Such reaction-diffusion systems are considered in some detail in the case of an isolated ring of cells, a mathematically convenient, though biologically unusual system. The investigation is chiefly concerned with the onset of instability. It is found that there are six essentially different forms which this may take. In the most interesting form stationary waves appear on the ring. It is suggested that this might account, for instance, for the tentacle patterns on Hydra and for whorled leaves. A system of reactions and diffusion on a sphere is also considered. Such a system appears to account for gastrulation. Another reaction system in two dimensions gives rise to patterns reminiscent of dappling. It is also suggested that stationary waves in two dimensions could account for the phenomena of phyllotaxis. The purpose of this paper is to discuss a possible mechanism by which the genes of a zygote may determine the anatomical structure of the resulting organism. The theory does not make any new hypotheses; it merely suggests that certain well-known physical laws are sufficient to account for many of the facts. The full understanding of the paper requires a good knowledge of mathematics, some biology, and some elementary chemistry. Since readers cannot be expected to be experts in all of these subjects, a number of elementary facts are explained, which can be found in text-books, but whose omission would make the paper difficult reading. In this section a mathematical model of the growing embryo will be described. This model will be a simplification and an idealization, and consequently a falsification. It is to be hoped that the features retained for discussion are those of greatest importance in the present state of knowledge. The model takes two slightly different forms. In one of them the cell theory is recognized but the cells are idealized into geometrical points.
Day surgery, preoperative assessment, gynaecology, urology, and plastics
Authors: Whymark Caroline , Junkin Ross , Ramsey Judith 
Published: November 2020

Abstract
To pass the written part of the FRCA, candidates must achieve the pass mark for the SAQs and the MCQ/ SBA papers combined. Therefore, doing particularly well in one paper, or one area, can compensate for another in which you have scored poorly. The 30 SBA questions is an area that candidates commonly find difficult. There is a feeling these questions are unjust and that it is impossible to second guess the examiners and choose the correct option. They feel further punished that four marks are awarded for each correct answer or lost for an incorrect choice. While this reflects the fact that four answers have been eliminated in the course of choosing the best answer, candidates often state it is an unfair ‘all or nothing’ way to mark these questions. They can commonly narrow the choice down to a final two options but report finding it difficult to then choose between them. They receive no credit having successfully eliminated three of the options and cite the SBA element as being the reason they failed the examination. These comments however are not supported by examination success data published by the RCoA. The pass rate for this paper was consistent at around 70% before and after the introduction of the SBA component in September 2011. We believe the concepts behind the SBAs are misunderstood by many. When asked to write a SBA question, candidates inevitably produce a five- part A to E multiple choice question but with only one correct answer. The finer points of SBA questions are lost among quickly written revision aids containing what the authors believe to be examination standard questions, when often they are not. Further, because SBAs are a relatively new element to the FRCA there is a limited bank of questions, and a highly restricted number in the public domain. Both these factors make practice of these questions difficult. Part of exam success is practice of the technique and question type in advance. We believe the practice of SBAs is an area to which candidates do not give enough attention.
Intensive care
Authors: Whymark Caroline , Junkin Ross , Ramsey Judith 
Published: November 2020

Abstract
To pass the written part of the FRCA, candidates must achieve the pass mark for the SAQs and the MCQ/ SBA papers combined. Therefore, doing particularly well in one paper, or one area, can compensate for another in which you have scored poorly. The 30 SBA questions is an area that candidates commonly find difficult. There is a feeling these questions are unjust and that it is impossible to second guess the examiners and choose the correct option. They feel further punished that four marks are awarded for each correct answer or lost for an incorrect choice. While this reflects the fact that four answers have been eliminated in the course of choosing the best answer, candidates often state it is an unfair ‘all or nothing’ way to mark these questions. They can commonly narrow the choice down to a final two options but report finding it difficult to then choose between them. They receive no credit having successfully eliminated three of the options and cite the SBA element as being the reason they failed the examination. These comments however are not supported by examination success data published by the RCoA. The pass rate for this paper was consistent at around 70% before and after the introduction of the SBA component in September 2011. We believe the concepts behind the SBAs are misunderstood by many. When asked to write a SBA question, candidates inevitably produce a five- part A to E multiple choice question but with only one correct answer. The finer points of SBA questions are lost among quickly written revision aids containing what the authors believe to be examination standard questions, when often they are not. Further, because SBAs are a relatively new element to the FRCA there is a limited bank of questions, and a highly restricted number in the public domain. Both these factors make practice of these questions difficult. Part of exam success is practice of the technique and question type in advance. We believe the practice of SBAs is an area to which candidates do not give enough attention.
Take Two Aspirin
Authors: Smith Gary 
Published: November 2020

Abstract
IBM’s Watson got an avalanche of publicity when it won Jeopardy, but Watson is potentially far more valuable as a massive digital database for doctors, lawyers, and other professionals who can benefit from fast, accurate access to information. A doctor who suspects that a patient may have a certain disease can ask Watson to list the recognized symptoms. A doctor who notices several abnormalities in a patient, but isn’t confident about which diseases are associated with these symptoms, can ask Watson to list the possible diseases. A doctor who is convinced that a patient has a certain illness can ask Watson to list the recommended treatments. In each case, Watson can make multiple suggestions, with associated probabilities and hyperlinks to the medical records and journal articles that it relied on for its recommendations. Watson and other computerized medical data bases are valuable resources that take advantage of the power of computers to acquire, store, and retrieve information. There are caveats though. One is simply that a medical data base is not nearly as reliable as a Jeopardy data base. Artificial intelligence algorithms are very good at finding patterns in data, but they are very bad at assessing the reliability of the data and the plausibility of a statistical analysis. It could end tragically if a doctor entered a patient’s symptoms into a black-box data-mining program and was told what treatments to use, without any explanation for the diagnosis or prescription. Think for a moment about your reaction if your doctor said, I don’t know why you are ill, but my computer says, “Take these pills.” I don’t know why you are ill, but my computer recommends surgery. Any medical software that uses neural networks or data reduction programs, such as principal components and factor analysis, will be hard-pressed to provide an explanation for the diagnosis and prescribed treatment. Patients won’t know. Doctors won’t know. Even the software engineers who created the black-box system won’t know. Nobody knows. Watson and similar programs are great as a reference tool, but they are not a substitute for doctors because: (a) the medical literature is often wrong; and (b) these errors are compounded by the use of data-mining software.
Coinage and Identity in the Roman Provinces
Authors: Howgego Christopher 
Published: November 2020

Abstract‘Identity is Now Seen Not as an Eternal given, but as something actively constructed and contested in a particular historical context, based on subjective, not objective criteria.’ For all that it may be a contingent construct, identity is a powerful driver of action, as we know all too well from our own experience. Identity matters. Coins have been described, in the words of Fergus Millar, as ‘the most deliberate of all symbols of public identity’. Yet the Roman historian will look in vain for any good introduction to, or systematic treatment of, the subject. That, in a nutshell, is the need which this volume seeks to address. It is worth emphasizing the words deliberate and public. It is relevant to recall the late second-century bc inscription which states the reasons why the people of Sestus decided to use its own bronze coinage. The first reason given is so that the city’s coin type should be used as a current type. In this context at least, coins were seen as a deliberate advertisement of public identity. What coinage most obviously provides is an enormous range of self-defined and explicit representations of public/official/communal identities, principally civic in nature. The material thus largely allows us to avoid the thorny problems associated with externally defined, implicit, and private identities. A public medium like coinage is not the place to look for overt opposition to Roman rule. And it invites, rather than answers, the question of to what extent public identities might have been understood as covert ‘resistance’ to Rome, to what extent they represented a self-definition designed to accommodate or play up to Roman attitudes, and to what extent they may even have been inspired or promoted by Rome itself. Identity has been a major focus of research in recent decades, for the obvious reason that it is particularly an issue when under threat. That consideration applies as much to our own scholarly context as it does to our subject, the Roman empire. The advent of the Euro has inevitably drawn attention to money in this context. Naturally there are major differences between now and then.
‘Belonging’ to Rome, ‘Remaining’ Greek: Coinage and Identity in Roman Macedonia
Authors: Kremydi-Sicilianou Sophia 
Published: November 2020

AbstractDuring a Period when the Western world, and especially Europe, has been undergoing radical changes, the concept and definition of ‘identity’ has naturally attracted the interest of sociologists, historians, and political scientists alike. This tendency has influenced classical studies and the way we approach ancient civilizations. Archaeologists, for example, tend to become more cautious concerning the connection between material civilization and ethnic identity, and the ‘objectivity’ of the available evidence, whether literary or material, is now often scrutinized. One of the main interests— but also difficulties—of this perspective is that it requires interdisciplinary research: in order to understand how private individuals, or social groups, perceived ‘themselves’, in other words what they considered as crucial for differentiating themselves from ‘others’, one cannot rely on partial evidence. Can, for example, the adoption of Roman names by members of the provincial elite be conceived as an adoption of Roman cultural identity? Other literary, epigraphic, and archaeological evidence clearly shows that this was not the case. The Roman empire was a state that incorporated many ethnic groups, with different political institutions and various religious beliefs. In this sense it is natural that contemporary studies on cultural identity have, to a large extent, concentrated on the imperial period. And a good many of them are dedicated to the interpretation of literary texts. The contribution of coinage to the understanding of identity under the Roman empire is what this book is about, and Howgego has set the general framework in his introduction. Before trying to explore what coins can contribute to our understanding of the civic identity of Macedonian cities, it is crucial to bear in mind the restrictions imposed by the nature of our material. It is clear that coin types represent deliberate choices made by certain individuals who possessed the authority to act in the name of the civic community they represented. Whose identity therefore do these coins reflect? Under the late Republic and the imperial period provincial cities possessed a restricted autonomy but were always subjected to Roman political authority. Their obligations towards Rome or their special privileges could vary according to the emperor’s will.