bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of active occupational stress management on psychosocial and physiological wellbeing: a pilot study
Authors: Jukic Tomislav , Ihan Alojz , Strojnik Vojko , Stubljar David , Starc Andrej 
Published: July 2020

Abstract
Background: The aim of the study was to address the working population with an occupational stress prevention program using mHealth solution and encourage them for healthy lifestyle choices.Methods: Sixteen participants were randomized from the corporate setting. A 24alife app with a good compliance program was selected. Test battery has been designed to test the physical readiness, psychological evaluation and biological blood markers for stress. Participants were followed up after 30, 60 and 90 days, respectively, within the intervention period. Weight of participants was tracked three times per month. Univariate analysis compared the continuous variables by One-Way Repeated-Measures ANOVA test when the data were normally distributed, or Wilcoxon rank sum test for abnormal distribution of variables.Results: Participants used the app with a compliance rate of 94.1%. The psychological evaluation revealed higher motivation for work, lower burnout scores and participants gave subjective responses of better general wellbeing. Some of the participants lost up to four kg of body mass. Physical readiness has also improved.Conclusions: Results of mHealth projects on corporate could include primary health care institutions and health ministry to extend the existing system to patients’ pockets where they can monitor their disease and increase the ability of self-care.
Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal
Authors: Volkman Sarah K. , Sarr Oumar , Steketee Richard W. , Schaffner Stephen F. , Dieye Yakou , Dieng Gnagna , Hainsworth Michael , Fall Fatou B. , Diouf Coumba Ndoffene , Ndiop Medoune , Cissé Moustapha , Gueye Alioune Badara , Guinot Philippe , Daniels Rachel F. , Deme Awa B. , Bei Amy K. , Sy Mouhamad , Thwing Julie , MacInnis Bronwyn , Earle Duncan , Guinovart Caterina , Sene Doudou , Hartl Daniel L. , Ndiaye Daouda , Wirth Dyann F. 
Published: July 2020

Abstract
Background Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history. Methods A genetic strategy was applied to better understand the contribution of imported infections and to test for local transmission in the very low prevalence region of Richard Toll, Senegal. Results Genetic relatedness analysis, based upon molecular barcode genotyping data derived from diagnostic material, provided evidence for both imported infections and ongoing local transmission in Richard Toll. Evidence for imported malaria included finding that a large proportion of Richard Toll parasites were genetically related to parasites from Thiès, Senegal, a region of moderate transmission with extensive available genotyping data. Evidence for ongoing local transmission included finding parasites of identical genotype that persisted across multiple transmission seasons as well as enrichment of highly related infections within the households of non-travellers compared to travellers. Conclusions These data indicate that, while a large number of infections may have been imported, there remains ongoing local malaria transmission in Richard Toll. These proof-of-concept findings underscore the value of genetic data to identify parasite relatedness and patterns of transmission to inform optimal intervention selection and placement.
A modular multi-agent framework for innovation diffusion in changing business environments: conceptualization, formalization and implementation
Authors: Johanning Simon , Scheller Fabian , Abitz Daniel , Wehner Claudius , Bruckner Thomas 
Published: July 2020

Abstract
Understanding how innovations are accepted in a dynamic and complex market environment is a crucial factor for competitive advantage. To understand the relevant factors for this diffusion and to predict success, empirically grounded agent-based models have become increasingly popular in recent years.

Despite the popularity of these innovation diffusion models, no common framework that integrates their diversity exists. This article presents a flexible, modular and extensible common description and implementation framework that allows to depict the large variety of model components found in existing models. The framework aims to provide a theoretically grounded description and implementation framework for empirically grounded agent-based models of innovation diffusion.

It identifies 30 component requirements to conceptualize an integrated formal framework description. Based on this formal description, a java-based implementation allowing for flexible configuration of existing and future models of innovation diffusion is developed.

As a variable decision support tool in decision-making processes on the adoption of innovations the framework is valuable for the investigation of a range of research questions on innovation diffusion, business model evaluation and infrastructure transformation.
A pilot randomised trial of home-based rehabilitation compared to usual care in patients with heart failure with preserved ejection fraction and their caregiver’s (REACH-HFpEF study): a process evaluation.
Authors: Smith Karen , Lang Chim , Wingham Jenny , Frost Julia , Greaves Colin , Abraham Charles , Warren Fiona , Coyle Joanne , Jolly Kate , Miles Jackie , Paul Kevin , Doherty Patrick , Davis Russell , Dalal Hasnain , Taylor Rod S 
Published: July 2020

Abstract
Background: Whilst heart failure (HF) with preserved ejection fraction (HFpEF) affects almost 50 percent of the HF population, evidence-based treatment options remain limited. However, there is emerging growing evidence of the potential value of exercise-based cardiac rehabilitation. This study reports the process evaluation of the Rehabilitation Enablement in Chronic Heart Failure (REACH-HF) intervention for HFpEF patients and their caregivers conducted as part of the REACH-HFpEF pilot trial. This study reports the process evaluation conducted as part of the REACH-HFpEF trial. Methods: Mixed methods Pprocess evaluation sub study parallel to a single centre (Tayside, Scotland) pilot randomised controlled trial with qualitativequantitative assessment of both intervention fidelity delivery and a qualitative exploration of HFpEF patients’ and caregivers’ experiences. The Rehabilitation EnAblement in Chronic Heart Failure (REACH-HF) intervention consisted of self-help manual for patients and caregivers, facilitated over 12 weeks by trained healthcare professionals. Data included audio-recorded intervention sessions; demographic information; intervention fidelity scores; and qualitative interviews conducted following completion of intervention in a purposeful sample of 15 HFpEF patients and 7 caregivers.,Results: Intervention fidelity analysis was indicative of the adequate delivery of the majority of the REACH-HF components, with three items relating caregiver involvement (addressing emotional consequences of being a caregiver, caregiver health and well-being, and closure of the session) scoring poorly. Qualitative information from the facilitator interactions and interviews identified three key themes and a number of sub-themes for patients and caregivers: (1) understanding their condition (2) emotional consequences of HF, and (3) patients’ and caregivers’ responses to the REACH-HF intervention were uncovered by qualitative interviews. Different professional backgrounds and typical models of service delivery of facilitators demonstrate to possibility of delivering this through either our HF or CR services of a combination of the two.Conclusions: The REACH-HF home-based facilitated intervention for HFpEF appears feasible and well accepted model for delivery of a CR intervention, with the potential to address key unmet needs of patients and their caregivers who are often excluded from service provision and current CR programmes. Results of this study will inform a future recently funded full multicentre randomised clinical trial.
Self-perceived Workplace Discrimination and Mental Health Among Immigrant Workers in Italy: a Cross-sectional Study
Authors: Napoli Anteo Di , Rossi Alessandra , Baralla Francesca , Ventura Martna , Gatta Rosaria , Perez Minica , Sarchiapone Marco , Mirisola Concetta , Petrelli Alessio 
Published: July 2020

Abstract
BackgroundThe process of immigration is associated with poor mental and physical health. While the workplace represents an important context of social integration, previous studies evaluating the effect of discrimination experienced in the workplace found worse mental health status among immigrants. The aim of this study was to investigate the association between self-perceived workplace discrimination and other personal experiences, such as self-perceived loneliness, level of life satisfaction, physical health, and mental well-being, among immigrants in Italy.MethodsA cross-sectional study was conducted on a sample of 12,408 immigrants (aged 15-64) living and working in Italy. Data derived from the first national survey on immigrants carried out by the Italian National Institute of Statistics (Istat). Mental health status was measured through the mental component summary (MCS) of the SF-12 questionnaire. A linear multivariate linear regression was carried out to evaluate the association between mental health status, self-perceived workplace discrimination, and sociodemographic factors; a structural equation model was used to test hypothesized relationships shown in a conceptual path analysis model.ResultsWorse mental health status was independently (p<0.001) associated with self-perceived workplace discrimination (β:-1.873), self-perceived loneliness (β:-3.021), level of life satisfaction (β:-2.775), and physical health status (β:-0.088). As confirmed by the structural equation model, the effect of self-perceived workplace discrimination on MCS was mediated by the other factors considered: self-perceived loneliness (13.6%), level of life satisfaction (13.6%), and physical health status (3.9%).ConclusionsOur study suggests that self-perceived workplace discrimination is associated with worse mental health status in immigrant workers, through personal experiences in the workplace and explain the effect of the exposure to workplace discrimination on immigrants’ psychological well-being. Our findings suggest that an overall public health response is needed to facilitate the social integration of immigrants and their access to health services, particularly those services that address mental health issues.
An Empirical Analysis of the Socioeconomic and Demographic characteristics influencing Birth Certification in Nigeria
Authors: Anaduaka Uchechi Shirley 
Published: July 2020

Abstract
Background: Promoting birth certification is instrumental to achieving target 16.9 of the Sustainable Development Goals: legal identity for all by 2030. However, limited research has investigated the determinants of birth certification of children in the sub-Saharan African context. This study analyzes the socioeconomic and demographic factors associated with the birth certification of children under-five years in Nigeria.
Methods: The study employed three rounds of the Nigerian Demographic and Health Survey involving 79487 children (0-4 years) in Nigeria. Birth certification was defined as whether a parent/caregiver had a child’s birth certificate at the time of the interview. Ordinary least squares and multilevel logistic regression models established the relationships between the socioeconomic and demographic factors and birth certification.
Results: Children under-five years who had a skilled attendant at birth, at least one vaccination, and maternal access to prenatal visits had about 25.6%, 60.5% and 35.0% higher odds of having their births certified. Children born to more educated mothers and fathers had 1.023 and 1.012 times the odds of birth certification. Children from average and rich households also had 13.2% and 34.2% higher odds of birth certification, respectively. Conversely, child age, higher birth order, longer birth intervals, polygyny, having at least two dead siblings, father being employed in a low skilled job, living far from a registration center and in a poor community are risk factors for birth certification. Maternal age at birth and paternal has non-linear, albeit weak effects on birth certification. Being large at birth, bank account ownership were also significant predictors of birth certification. Mixed effects were noted for religion, ethnicity and region. Finally, no significant effects were noted for gender, maternal occupation and rural residence.
Conclusions: The findings identify several socioeconomic and demographic factors associated with birth certification suggesting possible risks with improving birth certification in Nigeria. Access to health care and higher socioeconomic backgrounds are significant protectors of and distance to registration centers as obstacles to birth certification for children in Nigeria. Public policy strategies should encourage the use of health care services and also increase the number of registration centers in Nigeria.
Hypoxia induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic scleroderma
Authors: Mao Jing , Liu Jiexiong , Zhou Mei , Wang Guiqiang , Xiong Xia , Deng Yongqiong 
Published: July 2020

Abstract
Background: Endothelial mesenchymal transition (EndMT) is a key pathological event for vasculopathy, and is one of the early features and hallmarks of systemic scleroderma (SSc). It has been well-established that hypoxia contributes to EndMT. However, little is known about the effects of EndMT induced by hypoxia on the skin microvascular remodeling of SSc, as well as the underlying mechanism. Methods: Skin biopsy was performed for SSc patients and healthy controls, and skin tissues were collected for isobaric tags for the relative and absolute quantification (iTRAQ)-based proteomics and immunohistochemical test. Human microvascular endothelial cell line-1 (HMEC-1) cultured in hypoxic or normal conditions was treated by tamoxifen or bevacizumab. The expression of hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF)-a, CD31, α-smooth muscle actin (α-SMA), VE-cadherin, and fibronectin were detected at both the protein and mRNA level.Results: The iTRAQ-based proteomics indicated the significantly upregulated HIF-1 signal in the skin tissues of SSc patients. The immunohistochemical results demonstrated the significant downregulation of endothelial cell (EC) marker CD31 and the distinct positive staining of interstitial cell (IC) marker α-SMA at sites that lined the vessel lumens in skin tissues of SSc. Meanwhile, the positive staining of HIF-1α, which is a key transcription factor in response to chronic hypoxia, and VEGF-a were found to be diffusely distributed in SSc skin tissues. Consistent with these observations, HMEC-1 cells cultured under hypoxic conditions exhibited a significant decrease in CD31 and VE-cadherin expression, alongside the marked increase in the expression of α-SMA and fibronectin, as well as the distinct upregulation of HIF-1α and VEGF-a, when compared with those under normal conditions. It is noteworthy that the inhibition of HIF-1α by tamoxifen effectively downregulated the hypoxic induction of VEGF-a and α-SMA, while rescuing the hypoxic suppression of CD31. In addition, the VEGF-a inhibitor bevacizumab treatment had the same effect on the hypoxic expression of α-SMA and CD31, as a tamoxifen intervention, but did not reduce HIF-1α. Conclusion: These results suggest that the HIF-1α/VEGF signaling pathway has a critical role in mediating the effect of hypoxia-induced EndMT on the skin microvascular remodeling of SSc.
Circular RNA hsa_circ_000780 has been identified by genomic expression profile analysis as a potential diagnostic marker for gastric cancer
Authors: Song Jian , Yu Shuyong , Zhong Dunjing , Yang Weizhong , Jia Zhen , Yuan Guihong , Li Ping , Zhang Ronglin , Li Yini , Zhong Guobing , Chen Zhaowei 
Published: July 2020

Abstract
Background : The present study attempted to detect a specific circular RNA (circRNA) for the early diagnosis of gastric cancer (GC). Methods: We selected four patients with GC for this study. The total RNA of the malignant and adjacent tissues was extracted, and the circRNA was screened. The eight most upregulated and downregulated circRNAs with a statistically significant relation to GC and paired adjacent nontumorous tissues were identified using real-time fluorescent quantitative polymerase chain reaction (PCR). CircRNA expression was identified by quantitative reverse transcriptase PCR in 78 cases of GC and adjacent tissues, and in the gastric fluids of 30 patients with chronic nonatrophic gastritis, 30 patients with chronic atrophic gastritis, 21 with early GC, and 57 with advanced GC. Results: A total of 445 circRNAs, including 69 upregulated and 376 downregulated circRNAs, showed significant aberrant expression in GC tissues. A majority of the differentially expressed circRNAs originated from chr1, chr3, chr4, chr6, and chr11. Hsa_circ_000780 was significantly downregulated in 80.77% of GC tissues, and its level in GC tissues correlated with the tumor size, tumor stage, T stage, venous invasion, carcinoembryonic antigen, and carbohydrate antigen 19-9 expression. A crucial observation was the presence of this circRNA in the gastric fluid of patients with early and advanced GC. Conclusions: The present study uncovered a new hsa_circRNA expression profile in human GC, of which hsa_circ_000780 was significantly downregulated in GC tissues and in gastric fluid. It can be potentially used as a novel biomarker for early GC screening.
Occupational risk factors for shoulder chronic tendinous pathology in the Spanish automotive manufacturing sector: a case-control study.
Authors: DIEZ-CABALLERO BEATRIZ RODRIGUEZ , Alfonso-Beltran Joaquin , Bautista Iker J. , Pitarque Carlos Barrios 
Published: July 2020

Abstract
Introduction: Musculoskeletal Diseases (MSDs) are among the most prevalent health problems encountered in the workforce in Europe. Multiple risk factors contribute to their onset. In the present study, different individual risk factors for chronic tendinous pathology affecting the shoulder were analysed in a sample of workers from the automotive manufacturing sector. Methods: An observational retrospective study was conducted with 73 cases of officially recognised and compensated occupational diseases and 94 aleatory cases of healthy workers from the same car assembly company. The experimental group comprised individuals with tendinous chronic pathology of the rotator cuff. Multiple variables that identified the risks present in the job were assessed along with participants clinical evaluation. Furthermore, two standardised guidelines for risk factors assessment were also used: the Spanish National Institute of Social Security (INSS) and the American Occupational Information Network (O*Net). Both descriptive statistical analysis and Odds ratios calculations considering the occupational disease as a dependent variable were performed. Results: Using univariate analysis, the use of hand tools, exposure to mechanical pressure in the upper limbs and awkward postures were the most prevalent risk factors. Pressure on the palm of the hand and the hand tool impacting the hand were also important risk factors. Some psychosocial factors such as lack of autonomy and mental workload were also associated shoulder tendinous diseases. In the logistic regression model, age, load handling, and awkward postures were the core risk factors responsible for most of the tendinous chronic injuries of the shoulder in this sample of car assembly workers.Conclusions: Both ergonomic and psychosocial factors were present and increased the risk of developing occupational chronic tendinopathies at the shoulder in this sample of workers. Aging, load handling, and awkward postures showed the strongest predictive values. Greater knowledge of how risk factors interact would facilitate the design of better preventive workplace strategies.
Sedimentation and sediment geochemistry in a tropical mangrove channel meander, Sungai Kerteh, Peninsular Malaysia
Authors: Shaari Hasrizal Bin , Nasir Qatrunnada Mohd , Mohamed Che Abd Rahim , Yusoff Abdul Hafidz , Khalid Wan Mohd Afiq Wan Mohd , Naim Erick , Setiawan Riza Yuliratno , Anthony Edward J. 
Published: July 2020

Abstract
Tropical mangrove swamps are commonly characterized by dense networks of tidal channels that may show pronounced meandering and dendritic patterns. Channel meanders are sometimes accompanied by cut offs, and, like classical fluvial meanders, record changes in hydrology and sedimentation over time. Channel meandering can, thus, be an important process that contributes to spatial and temporal variability in the preserved record of the sedimentology and geochemistry of mangrove sediments. The aim of this study is to highlight changes in channel meander sedimentation in response to a meander cut-off in a tropical mangrove swamp. Two short sediment cores were sampled, respectively from a point bar (core KR1, 122 cm) at the junction with the neck cut-off and inside the cut-off (core KR2, 98 cm) in the Sungai Kerteh mangroves of Peninsular Malaysia. The profile comparison was based on sediment characteristics, total organic carbon (TOC) and selected elements (Fe, Na, Mg, Mn, Ba and Sr). Sedimentation rates at both sites were determined from 210 Pb. A smaller standard deviation of mean grain size (MGS) was found at the point bar (4.37±0.51 ϕ) than in the cut-off (4.43 ±1.76 ϕ), indicating a difference in flow velocity between the two settings. A small difference in sedimentation rate between the upper (0.41 cm.yr -1 ) and bottom (0.50 cm.yr -1 ) parts of core KR1 suggests that water velocity at the point bar area has been rather uniform over the timescale of sedimentation. On the other hand, a higher sedimentation rate in the bottom (0.60 cm.yr -1 ), compared to the upper (0.39 cm.yr -1 ) part of core KR2 may reflect a reduction in sediment supply following cut-off. This change also resulted in increased accumulation of selected elements and TOC at the cut-off site from a depth of ~ 60 cm to the core-top segment probably associated with a slowing down of sediment settling. A higher TOC recorded in the cut-off (2.74±1.42%) compared to the point bar (1.14±0.46%) suggests a propensity for prolonged in-situ accumulation of organic matter in the abandoned meander bend. This study provides grain-size and sediment geochemical information that is consistent with patterns of long-term active and inactive sedimentation in the meander bends of mangrove channels.