bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography
Authors: Abdighahroudi Mohammad Sajjad , Lutze Holger V. , Schmidt Torsten C. 
Published: May 2020

AbstractN-containing heterocycles (NCHs) are largely used as precursors for pharmaceuticals and can enter the environment. Some NCHs have been shown to be toxic, persistent, and very mobile in the environment. Thus, they have received increasing attention in the past years. However, the analysis of these polar compounds in environmental samples is still a challenge for liquid chromatography. This paper investigates the use of mixed-mode liquid chromatography (MMLC), which has reversed-phase and ion exchange characteristics for measurements of NCHs in water. NCHs with low pKa (i.e., < 2.5) display mainly reversed-phase interactions (neutral species) with the stationary phase and those with higher pKa (i.e., > 5) interact by a mixture of reversed-phase/ion exchange/HILIC mechanism. It was also shown that the presented method performs well in the quantification of the majority of the selected NCHs in surface water with MDLs between 3 and 6 μg/L, a low matrix effect and recoveries in the range of 77–96% except for pyridazine exhibiting 32% were achieved. The method was successfully employed to follow the degradation of NCHs in ozonation.
Echocardiographic and Clinical Follow‐up After Aortic Valve Neocuspidization Using Autologous Pericardium
Authors: Koechlin Luca , Schurr Ulrich , Miazza Jules , Imhof Sebastian , Maurer Markus , Erb Joachim , Gahl Brigitta , Santer David , Berdajs Denis , Eckstein Friedrich S. , Reuthebuch Oliver 
Published: May 2020

AbstractIntroductionMid‐term data from a single centre showed the safety and durability of aortic valve neocuspidization using autologous pericardium (OZAKI procedure). Since validation data from other centres are missing, aim of this study was to analyze echocardiographic and clinical results of our first patients that were operated with the OZAKI technique.MethodsThirty‐five patients (24 males, median (IQR) age 72.0 (59.0, 76.0) years) with aortic stenosis (AS; n = 10), aortic insufficiency (AR; n = 13) or a combination of both (AS/AR; n = 12), underwent aortic valve neocuspidization in our institution between September 2015 and May 2017. Echocardiographic follow‐up was performed using a standardized examination protocol.ResultsClinical follow‐up was completed in 97% of the patients. Median (IQR) follow‐up time was 645 (430, 813) days. Mortality rate was 9% (n = 1: aspiration pneumonia; n = 1: unknown; n = 1: anaphylactic shock), and the reoperation rate was 3% (n = 1: endocarditis). No pacemaker implantation was necessary after isolated OZAKI procedures. Echocardiographic follow‐up was performed in 83% of the patients (n = 29; median (IQR) time 664 (497, 815) days). Median (IQR) mean and peak gradients were 6 (5,9) mmHg and 12 (8, 17) mmHg. Moderate aortic regurgitation was seen in 2 patients (7%). No severe aortic regurgitation or moderate or severe aortic stenosis occurred within the follow‐up period.ConclusionsThe OZAKI procedure is reliable and reoperation due to structural valve deterioration nil within a median 645 days follow‐up period. The low rate of moderate aortic regurgitation will be surveilled very closely. Further studies are required to evaluate the significance of this procedure in aortic valve surgery.Clinical registration numberClinicalTrials.gov (ID NCT03677804)
Prognostic value of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in multiple myeloma patients treated with thalidomide-based regimen
Authors: Szudy-Szczyrek Aneta , Mlak Radosław , Mielnik Michał , Szczyrek Michał , Nowaczyńska Aleksandra , Homa-Mlak Iwona , Zmorzyński Szymon , Kuśmierczuk Kinga , Sompor Jacek , Filip Agata , Małecka-Massalska Teresa , Hus Marek 
Published: May 2020

AbstractNeutrophils to lymphocytes ratio (NLR) and platelets to lymphocytes ratio (PLR) are considered as laboratory markers of inflammation. They can be potentially useful in predicting the course of multiple neoplasms including selected hematological cancers. The aim of the study was to assess the value of NLR and PLR in predicting the effects of therapy and prognosis in multiple myeloma patients treated with thalidomide-based regimen. The study group consisted of 100 patients treated with the first line CTD (cyclophosphamide, thalidomide, and dexamethasone) chemotherapy. The NLR and PLR were calculated before treatment. High NLR was observed in patients with higher stage of the disease, with poor performance status, hypercalcemia, and high CRP. High PLR was associated with low BMI and high CRP. In patients with high NLR, significantly shorter PFS was observed (17 vs. 26 months,p = 0.0405). In addition, high values of NLR and PLR were associated with significantly shorter OS (38 vs. 79 months,p = 0.0010; 40 vs. 78 months,p = 0.0058). Summarizing, NLR and PLR have a significant independent prognostic value for multiple myeloma patients. Furthermore, the NLR can be a predictive marker for the outcome of thalidomide-based chemotherapy.
Videokonsultationen durch Psychotherapeuten in Zeiten der COVID-19-Pandemie
Authors: Haun Markus W. , Hoffmann Mariell , Tönnies Justus , Dinger Ulrike , Hartmann Mechthild , Friederich Hans-Christoph 
Published: May 2020

ZusammenfassungWegen der durch die „corona virus disease 2019“ (COVID-19) ausgelösten Pandemie und den resultierenden Beeinträchtigungen persönlicher (d. h. von Angesicht zu Angesicht stattfindender) Behandlung haben Videokonsultationen in der Erbringung von Gesundheitsleistungen massiv an Bedeutung zugenommen. Die meisten Psychotherapeuten haben allerdings bis dato wenig praktische Erfahrung in der Durchführung von Videokonsultationen, nicht zuletzt auch aufgrund bisher eingeschränkter Möglichkeiten zur Abrechnung mit den Kostenträgern. Der vorliegende Beitrag stellt (1) eine Übersicht über die Wirksamkeit per Videokonsultation durchgeführter psychotherapeutischer Interventionen bei depressiven und Angststörungen, (2) Empfehlungen zur spezifischen Gestaltung des Behandlungsrahmens sowie (3) erste Erfahrungen von Patienten und Psychotherapeuten aus einer deutschen Machbarkeitsstudie sowie mit dem Routineangebot im Krankenhaus während der COVID-19-Pandemie vor.
First application of intraoperative MRI of the liver during ALPPS procedure for colorectal liver metastases
Authors: Riediger Carina , Plodeck Verena , Fritzmann Johannes , Pape Alexander , Kohler Alexander , Lachmann Björn , Koch Thea , Kühn Jens-Peter , Hoffmann Ralf-Thorsten , Weitz Jürgen 
Published: May 2020

Abstract
Purpose
Intraoperative detection of intrahepatic lesions can be demanding. The use of preoperative contrast-enhanced magnetic resonance imaging (MRI) or computer tomography (CT) combined with intraoperative ultrasound of the liver is state of the art. Near totally regressed colorectal liver metastases (CRLM) after neoadjuvant chemotherapy or nodules in severely altered liver tissue as steatosis or cirrhosis are often hard to detect during the operative procedure. Especially differentiation between benign atypical nodules and malignant tumors can be very difficult. The intraoperative use of contrast-enhanced ultrasound or intraoperative navigation are helpful tools. However, both methods show relevant limitations.
The use of intraoperative MRI (ioMRI) can overcome this problem. Relevant structures can be marked within the operative site or immediate control of complete tumor resection can be achieved. This might allow immediate surgical optimization in case of failure.

Methods
We report the intraoperative application of ioMRI in a case of a 61-year-old male patient suffering from rectal cancer with 10 synchronous bilobar CRLM who was treated stepwise by multimodal treatment and staged hepatectomy. Intraoperative contrast-enhanced MRI of the liver was used during completion procedure of an extended right hemihepatectomy performed as “Associating Liver Partition and Portal vein Ligation for Staged hepatectomy (ALPPS)”.

Results
ioMRI provided excellent images and showed absence of liver metastases in the liver remnant. Procedure of ioMRI was safe, fast and feasible.

Conclusion
To the best of our knowledge, we describe the first case of intraoperative application of a contrast-enhanced MRI during open liver surgery at the University Hospital of Dresden.
Dorsal prefrontal and premotor cortex of the ferret as defined by distinctive patterns of thalamo-cortical projections
Authors: Radtke-Schuller Susanne , Town Stephen M. , Yin Pingbo , Elgueda Diego , Schuller Gerd , Bizley Jennifer K. , Shamma Shihab A. , Fritz Jonathan B. 
Published: May 2020

AbstractRecent studies of the neurobiology of the dorsal frontal cortex (FC) of the ferret have illuminated its key role in the attention network, top-down cognitive control of sensory processing, and goal directed behavior. To elucidate the neuroanatomical regions of the dorsal FC, and delineate the boundary between premotor cortex (PMC) and dorsal prefrontal cortex (dPFC), we placed retrograde tracers in adult ferret dorsal FC anterior to primary motor cortex and analyzed thalamo-cortical connectivity. Cyto- and myeloarchitectural differences across dorsal FC and the distinctive projection patterns from thalamic nuclei, especially from the subnuclei of the medial dorsal (MD) nucleus and the ventral thalamic nuclear group, make it possible to clearly differentiate three separate dorsal FC fields anterior to primary motor cortex: polar dPFC (dPFCpol), dPFC, and PMC. Based on the thalamic connectivity, there is a striking similarity of the ferret’s dorsal FC fields with other species. This possible homology opens up new questions for future comparative neuroanatomical and functional studies.
QTL mapping for pre-harvest sprouting resistance in japonica rice varieties utilizing genome re-sequencing
Authors: Cheon Kyeong-Seong , Won Yong Jae , Jeong Young-Min , Lee Youn-Young , Kang Do-Yu , Oh Jun , Oh Hyoja , Kim Song Lim , Kim Nyunhee , Lee Eungyeong , Yoon In Sun , Choi Inchan , Baek Jeongho , Kim Kyung-Hwan , Park Hyun-Su , Ji Hyeonso 
Published: May 2020

AbstractPre-harvest sprouting (PHS) leads to serious economic losses because of reductions in yield and quality. To analyze the quantitative trait loci (QTLs) for PHS resistance in japonica rice, PHS rates on panicles were measured in 160 recombinant inbred lines (RILs) derived from a cross between the temperate japonica varieties Odae (PHS resistant) and Unbong40 (PHS susceptible) under two different environmental conditions—field (summer) and greenhouse (winter) environments. Genome re-sequencing of the parental varieties detected 266,773 DNA polymorphisms including 248,255 single nucleotide polymorphisms and 18,518 insertions/deletions. We constructed a genetic map comprising 239 kompetitive allele-specific PCR and 49 cleaved amplified polymorphic sequence markers. In the field environment, two major QTLs, qPHS-3FD and qPHS-11FD, were identified on chromosomes 3 and 11, respectively, whereas three major QTLs, qPHS-3GH, qPHS-4GH, and qPHS-11GH, were identified on chromosomes 3, 4, and 11, respectively, in the greenhouse environment. qPHS-11GH and qPHS-11FD had similar locations on chromosome 11, suggesting the existence of a gene conferring stable PHS resistance effects under different environmental conditions. The QTLs identified in this study can be used to improve the PHS resistance of japonica varieties, and they may improve our understanding of the genetic basis of PHS resistance.
Modeling Personalized Adjuvant TreaTment in EaRly stage coloN cancer (PATTERN)
Authors: Jongeneel Gabrielle , Greuter Marjolein J. E. , van Erning Felice N. , Koopman Miriam , Medema Jan P. , Kandimalla Raju , Goel Ajay , Bujanda Luis , Meijer Gerrit A. , Fijneman Remond J. A. , van Oijen Martijn G. H. , Ijzermans Jan , Punt Cornelis J. A. , Vink Geraldine R. , Coupé Veerle M. H. 
Published: May 2020

Abstract
Aim
To develop a decision model for the population-level evaluation of strategies to improve the selection of stage II colon cancer (CC) patients who benefit from adjuvant chemotherapy.

Methods
A Markov cohort model with a one-month cycle length and a lifelong time horizon was developed. Five health states were included; diagnosis, 90-day mortality, death other causes, recurrence and CC death. Data from the Netherlands Cancer Registry were used to parameterize the model. Transition probabilities were estimated using parametric survival models including relevant clinical and pathological covariates. Subsequently, biomarker status was implemented using external data. Treatment effect was incorporated using pooled trial data. Model development, data sources used, parameter estimation, and internal and external validation are described in detail. To illustrate the use of the model, three example strategies were evaluated in which allocation of treatment was based on (A) 100% adherence to the Dutch guidelines, (B) observed adherence to guideline recommendations and (C) a biomarker-driven strategy.

Results
Overall, the model showed good internal and external validity. Age, tumor growth, tumor sidedness, evaluated lymph nodes, and biomarker status were included as covariates. For the example strategies, the model predicted 83, 87 and 77 CC deaths after 5 years in a cohort of 1000 patients for strategies A, B and C, respectively.

Conclusion
This model can be used to evaluate strategies for the allocation of adjuvant chemotherapy in stage II CC patients. In future studies, the model will be used to estimate population-level long-term health gain and cost-effectiveness of biomarker-based selection strategies.
Constructing a Human Atrial Fibre Atlas
Authors: Roney Caroline H. , Bendikas Rokas , Pashakhanloo Farhad , Corrado Cesare , Vigmond Edward J. , McVeigh Elliot R. , Trayanova Natalia A. , Niederer Steven A. 
Published: May 2020

AbstractAtrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy measurements are not currently available, and consequently assigning fibre fields to atrial models is challenging. We aimed to construct an atrial fibre atlas from a high-resolution DTMRI dataset that optimally reproduces electrophysiology simulation predictions corresponding to patient-specific fibre fields, and to develop a methodology for automatically assigning fibres to patient-specific anatomies. We extended an atrial coordinate system to map the pulmonary veins, vena cava and appendages to standardised positions in the coordinate system corresponding to the average location across the anatomies. We then expressed each fibre field in this atrial coordinate system and calculated an average fibre field. To assess the effects of fibre field on patient-specific modelling predictions, we calculated paced activation time maps and electrical driver locations during AF. In total, 756 activation time maps were calculated (7 anatomies with 9 fibre maps and 2 pacing locations, for the endocardial, epicardial and bilayer surface models of the LA and RA). Patient-specific fibre fields had a relatively small effect on average paced activation maps (range of mean local activation time difference for LA fields: 2.67–3.60 ms, and for RA fields: 2.29–3.44 ms), but had a larger effect on maximum LAT differences (range for LA 12.7–16.6%; range for RA 11.9–15.0%). A total of 126 phase singularity density maps were calculated (7 anatomies with 9 fibre maps for the LA and RA bilayer models). The fibre field corresponding to anatomy 1 had the highest median PS density map correlation coefficient for LA bilayer simulations (0.44 compared to the other correlations, ranging from 0.14 to 0.39), while the average fibre field had the highest correlation for the RA bilayer simulations (0.61 compared to the other correlations, ranging from 0.37 to 0.56). For sinus rhythm simulations, average activation time is robust to fibre field direction; however, maximum differences can still be significant. Patient specific fibres are more important for arrhythmia simulations, particularly in the left atrium. We propose using the fibre field corresponding to DTMRI dataset 1 for LA simulations, and the average fibre field for RA simulations as these optimally predicted arrhythmia properties.
Personalized Psychotherapy for Outpatients with Major Depression and Anxiety Disorders: Transdiagnostic Versus Diagnosis-Specific Group Cognitive Behavioural Therapy
Authors: Eskildsen Anita , Reinholt Nina , van Bronswijk Suzanne , Brund René B. K. , Christensen Anne B. , Hvenegaard Morten , Arendt Mikkel , Alrø Anja , Poulsen Stig , Rosenberg Nicole K. , Huibers Marcus J. H. , Arnfred Sidse 
Published: May 2020

Abstract
Background
Only about half of all patients with anxiety disorders or major depression respond to cognitive behaviour therapy (CBT), even though this is an evidence-based treatment. Personalized treatment offers an approach to increase the number of patients who respond to therapy. The aim of this study was to examine predictors and moderators of (differential) treatment outcomes in transdiagnostic versus diagnosis-specific group CBT.

Methods
A sample of 291 patients from three different mental health clinics in Denmark was randomized to either transdiagnostic or diagnosis-specific group CBT. The study outcome was the regression slope of the individual patient's repeated scores on the WHO-5 Well-being Index. Pre-treatment variables were identified as moderators or predictors through a two-step variable selection approach.

Results
While the two-step approach failed to identify any moderators, four predictors were found: level of positive affect, duration of disorder, the detachment personality trait, and the coping strategy of cognitive reappraisal. A prognostic index was constructed, but did not seem to be robust across treatment sites.

Conclusions
Our findings give insufficient evidence to support a recommendation of either transdiagnostic or diagnosis-specific CBT for a given patient or to predict the response to the applied group therapies.
Day fines: asymmetric information and the secondary enforcement system
Authors: Kantorowicz-Reznichenko Elena , Kerk Maximilian 
Published: May 2020

AbstractThe most common pecuniary sanction, i.e. fixed-fines, places an emphasis on the severity of the crime. This fine has the problem of being either too high for poorer offenders to pay or too low for the richer offenders to be deterred. Day-fines, on the other hand, systematically account for the financial situation of the offender as well as for the severity of his offense. Consequently, it imposes equivalent burden of punishment on offenders who committed similar crimes, regardless of their wealth. However, a problem of asymmetric information is raised. Accurate financial information is essential for the efficiency of day-fines, yet its collection is costly. Day-fines receive increasing attention from policy-makers around the world. Nonetheless, it is under-researched in the law and economics literature. Therefore, this article is the first to formally analyze the problem of asymmetric information in the context of day-fines and to develop an optimal secondary enforcement system that would incentivize criminals to provide accurate information regarding their wealth.
Best practices in replication: a case study of common information in coordination games
Authors: Chen Roy , Chen Yan , Riyanto Yohanes E. 
Published: May 2020

AbstractRecently, social science research replicability has received close examination, with discussions revolving around the degree of success in replicating experimental results. We lend insight to the replication discussion by examining the quality of replication studies. We examine how even a seemingly minor protocol deviation in the experimental process (Camerer et al. in Science 351(6280):143–1436, 2016. 10.1126/science.aaf0918), the removal of common information, can lead to a finding of “non-replication” of the results from the original study (Chen and Chen in Am Econ Rev 101(6):2562–2589, 2011). Our analysis of the data from the original study, its replication, and a series of new experiments shows that, with common information, we obtain the original result in Chen and Chen (2011), whereas without common information, we obtain the null result in Camerer et al. (2016). Together, we use our findings to propose a set of procedure recommendations to increase the quality of replications of laboratory experiments in the social sciences.
Opportunity Costs Pacifism
Authors: Pattison James 
Published: May 2020

AbstractIf the resources used to wage wars could be spent elsewhere and save more lives, does this mean that wars are unjustified? This article considers this question, which has been largely overlooked by Just War Theorists and pacifists. It focuses on whether the opportunity costs of war lead to a form of pacifism, which it calls ‘Opportunity Costs Pacifism’. The article argues that Opportunity Costs Pacifism is, at the more ideal level, compelling. It suggests that the only plausible response to Opportunity Costs Pacifism applies in highly nonideal circumstances. This has major implications for Just War Theory and pacifism since it is only at the highly nonideal level that war can be justified.
Comparing the post-WWII publication histories of oceanography and marine geoscience
Authors: Mitchell Neil C. 
Published: May 2020

AbstractOceanography and marine geosciences are closely related subjects, though they have had differing influences. The UK, which has experienced the financial benefits of North Sea oil and gas, while also having an extensive fishing industry and a science base linked to other English-speaking countries and European countries, potentially illustrates some changing influences and collaborative tendencies well. In this article, differences in article publication rates and collaborative tendencies, both globally and for the UK, are examined using the Web of Science™, Scopus™ and Georef™ for the period 1946–2018. The results show that publication rates of global oceanography articles rose exponentially faster than all global scientific publishing from the mid-1960s to 1980. Subsequently, the exponential rate of increase slowed though has remained faster than global science publishing. Global Marine Geoscience publication rates increased into the late 1980s, but have since declined. UK oceanography has roughly followed global trends, though its share of global oceanographic publishing declined from 28% in the 1950s to 8% in 2018. UK Marine Geoscience publishing has also generally followed global trends for that field. However, its share of global publications abruptly increased from 4.9% (average 1960–1980) to 13.2% by 1990, largely due to articles arising from UK participation in the Deep-Sea Drilling Project and Ocean Drilling Program. Oceanography and marine geoscience have also experienced strongly differing histories of collaborative articles over the last four decades. While oceanographic articles co-authored with researchers in other countries have been steadily increasing as a share of total UK Oceanography articles, those of marine geoscience peaked in 1990 and have since declined, though remained at high levels similar to those experienced by 2018 in Oceanography. Comparing global publication rates in both fields with measures of data and sample collection at sea suggests fundamental changes occurred in the way research was carried out. For example, Marine Geoscience publication rates were strongly correlated with geophysical track-line distances for the decade until ~1970, but were inversely correlated for the decade after then. This reflects, for example, the development of plate tectonics, which partly involved analysis of existing marine geophysical data, improved equipment capabilities and the increased role of scientific drilling.