bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inefficacy: the tipping point of driver burnout
Authors: Thomas Stephanie P. , Liao-Troth Sara , Williams Donnie F. 
Published: May 2020

PurposeTruck drivers keep supply chains moving, but driver shortages and high turnover levels plague the industry. The purpose of this research is to examine the three dimensions of Maslach's job burnout model: exhaustion, cynicism and professional inefficacy, as it relates to role stressors and turnover intention. Logistics boundary spanners such as truck drivers appear to be especially susceptible to job burnout. Role theory and organizational support theory were used to develop hypotheses.Design/methodology/approachIndividual level survey data were collected from 190 truck driver respondents (not owner operators) at two large truck stops. Data were analyzed using structural equation modeling.FindingsFindings suggest that the relationship between role stressors and the dimensions of job burnout are not all the same. Role conflict significantly impacts exhaustion and cynicism. Role ambiguity significantly impacts cynicism and inefficacy. Results support a progression through burnout dimensions that begins with exhaustion and ends with inefficacy. Inefficacy was significantly related to intention to stay. Organizational support is a way to help drivers mitigate feelings of inefficacy.Practical implicationsManagers in trucking organizations can track burnout levels in their drivers using the Maslach Burnout Inventory with a specific focus on monitoring feelings of inefficacy, which may help lower turnover levels.Originality/valueThe findings support that the burnout dimension of inefficacy is the strongest indicator that a driver is considering leaving his current organization or the industry. This is contrary to other studies that have focused on the other two burnout dimensions.
A meaning-based framework for customer loyalty
Authors: Närvänen Elina , Kuusela Hannu , Paavola Heli , Sirola Noora 
Published: May 2020

PurposeThis paper's purpose is to develop a meaning-based framework for customer loyalty by examining how consumers make sense of customer loyalty through meanings and metaphors.Design/methodology/approachA qualitative study based on in-depth interviews and focus group data in the retail context was conducted with Finnish customers. The data were analysed with qualitative data analysis techniques such as the constant comparative technique.FindingsThe empirical findings comprise eight loyalty meanings characterised by two dimensions. The first dimension is reflexive vs. routinised, and the second dimension is private vs. social. The loyalty types are dimensionalised through four metaphors: loyalty as freedom of choice; as being conventional and binding; and as belongingness.Practical implicationsThe findings improve the way customer loyalty currently is understood in the retail setting. The paper proposes that customer insight that utilises thick data can be used to grasp loyalty meanings. These data are rich in context and detail, and they take into account customers' everyday lives. Utilising thick data in the form of storytelling fuels customers' meaning-making related to customer loyalty, potentially enriching their relationship with the retailer.Originality/valueCustomer loyalty has been driven largely by a transactional and company-centric perspective. This article presents an alternative view of customer loyalty that accounts for the variety of meanings that customers may assign to their loyalty-related thoughts and behaviours.
Expatriate management in hostile environments from a multi-stakeholder perspective – a systematic review
Authors: Faeth Pia Charlotte , Kittler Markus G. 
Published: May 2020

PurposeThe successful management of business expatriates and their families in hostile environments (HE) is a current concern for academics and human resources (HR) practitioners alike. Terrorism and other forms of violent crime have become salient topics on the public agenda, and international organizations are increasingly affected. Hence, scholarly interest in the HR implications for organizations sending staff to HEs has recently grown, and a nascent research area has emerged. This paper is the first systematic review synthesizing emerging literature in the field of expatriate management in HEs and its theoretical foundations, applying a multi-stakeholder perspective.Design/methodology/approachFollowing accepted review procedures, systematic searches were conducted across three major databases. Manual search in target journals provided additional scrutiny.FindingsAfter analysing 28 articles, four main stakeholders were identified as follows: environments, expatriates, assigning organizations and the expatriates' social networks. Findings reveal the ways of how all stakeholders can affect expatiation success or be affected so that the success of the assignment is jeopardised.Originality/valueOur paper illustrates how these diverse articles can be linked within a comprehensive multi-stakeholder framework and provides avenues for future research. We also shift attention to neglected theoretical perspectives that might further improve the understanding of expatriates in HEs while offering actionable guidance for managerial and organizational practices.
Rock‐physics forward modelling to predict seismic behaviour: A case study for exploration target in Mahanadi basin, East Coast of India
Authors: Mondal Samit , Yadav Ashok , Chatterjee Rima 
Published: May 2020

ABSTRACTOne of the major aspects of rock‐physics forward modelling is to predict seismic behaviour at an undrilled location using drilled well data. It is important to model the rock and fluid properties away from drilled wells to characterize the reservoir and investigate the root causes of different seismic responses. Using the forward modelling technique, it is possible to explain the amplitude responses of present seismic data in terms of probable rock and reservoir properties. In this context, rock‐physics modelling adds significant values in the prospect maturation process by reducing the risk of reservoir presence in exploration and appraisal phases. The synthetic amplitude variation with offset gathers from the forward model is compared with real seismic gathers to ensure the fidelity of the existing geological model. ‘Prospect A’ in the study area has been identified from seismic interpretation, which was deposited as slope fan sediments in Mahanadi basin, East Coast of India. The mapped prospect has shown class‐I amplitude variation with offset response in seismic without any direct hydrocarbon indicator support. The existing geological model suggests the presence of an excellent gas reservoir with proven charge access from the fetch area, moderate porosity and type of lithology within this fan prospect. But, whether the seismic response from this geological model will exhibit a class‐I amplitude variation with offset behaviour or ‘dim spot’ will be visible; the objective of the present study is to investigate these queries. A rock‐physics depth trend analysis has been done to envisage the possibilities of class‐I reservoir in ‘Prospect A’. Forward modelling, using a combination of mechanical and chemical compaction, shows the synthetic gas gathers at ‘Prospect A’, which are class I in nature. The study has also depicted 2D forward modelling using lithology and fluid properties of discovery well within similar stratigraphy to predict whether ‘dim spot’ will be seen in seismic. The estimated change in synthetic amplitude response has been observed as ∼5% at contact, which suggests that the changes will not be visible in seismic. The study connects the existing geological model with a top‐down seismic interpretation using rock‐physics forward modelling technique to mature a deep‐water exploratory prospect.
assignR: An r package for isotope‐based geographic assignment
Authors: Ma Chao , Vander Zanden Hannah B. , Wunder Michael B. , Bowen Gabriel J. 
Published: May 2020

Abstract

Methods for inferring geographic origin from the stable isotope composition of animal tissues are widely used in movement ecology, but few computational tools and standards for data interpretation are available.

We introduce the assignR r package, which provides a structured, flexible toolkit for isotope‐based migration data analysis and interpretation using a widely adopted semi‐parametric Bayesian inversion method.

assignR bundles data resources and functions that support data interpretation, hypothesis‐testing and quality assessment, allowing end‐to‐end data analysis with only a few lines of code. Tools for post hoc analysis offer robust, standardized methods for aggregating information from multiple individuals, assignment of individuals to a sub‐region of the study area and comparison of potential regions of origin using odds ratios. Assessment tools quantify the quality and power of the isotopic assignments and can be used to test prototype study designs.

The assignR package should increase the accessibility of isotopic geolocation methods. assignR supports flexible data sources and analysis decisions, making it suitable for a wide range of applications, but also promotes standardization that will help foster increased consistency and comparability among studies and a more holistic understanding of animal migration. Lastly, assignR can help make isotope‐based geolocation research more efficient by helping researchers plan projects to be optimally aligned with their research questions.
Nutritional Deficits In Children With Cancer: A Situation‐Specific Theory
Authors: Teixeira Iane Ximenes , de Oliveira Lopes Marcos Venícios , Diniz Camila Maciel 
Published: May 2020

PURPOSETo construct a situation‐specific theory (SST) to represent nutritional deficits for assessing children with cancer.DATA SOURCESLiterature review.DATA SYNTHESISThe SST included the definition of key concepts, a pictorial scheme, propositions, causal relationships, and evidence for nursing practice.CONCLUSIONSIt was possible to characterize the elements as antecedent and consequent clinical factors to allow for an understanding of the existing relationships between them and their temporality. These elements differed considerably from those included in NANDA International.IMPLICATIONS FOR NURSING PRACTICEThis study provides additional information so that nurses in clinical practice can infer the presence of nutritional deficits in children with cancer early, given the risk already inherent in the diagnosis of cancer and treatment.
Acute Alcohol Intake Produces Widespread Decreases in Cortical Resting Signal Variability in Healthy Social Drinkers
Authors: Sevel Landrew , Stennett Bethany , Schneider Victor , Bush Nicholas , Nixon Sara Jo , Robinson Michael , Boissoneault Jeff 
Published: May 2020

BackgroundAcute alcohol intoxication has wide‐ranging neurobehavioral effects on psychomotor, attentional, inhibitory, and memory‐related cognitive processes. These effects are mirrored in disruption of neural metabolism, functional activation, and functional network coherence. Metrics of intraregional neural dynamics such as regional signal variability (RSV) and brain entropy (BEN) may capture unique aspects of neural functional capacity in healthy and clinical populations; however, alcohol’s influence on these metrics is unclear. The present study aimed to elucidate the influence of acute alcohol intoxication on RSV and to clarify these effects with subsequent BEN analyses.Methods26 healthy adults between 25 and 45 years of age (65.4% women) participated in 2 counterbalanced sessions. In one, participants consumed a beverage containing alcohol sufficient to produce a breath alcohol concentration of 0.08 g/dl. In the other, they consumed a placebo beverage. Approximately 35 minutes after beverage consumption, participants completed a 9‐minute resting‐state fMRI scan. Whole‐brain, voxel‐wise standard deviation was used to assess RSV, which was compared between sessions. Within clusters displaying alterations in RSV, sample entropy was calculated to assess BEN.ResultsCompared to the placebo, alcohol intake resulted in widespread reductions in RSV in the bilateral middle frontal, right inferior frontal, right superior frontal, bilateral posterior cingulate, bilateral middle temporal, right supramarginal gyri, and bilateral inferior parietal lobule. Within these clusters, significant reductions in BEN were found in the bilateral middle frontal and right superior frontal gyri. No effects were noted in subcortical or cerebellar areas.ConclusionsFindings indicate that alcohol intake produces diffuse reductions in RSV among structures associated with attentional processes. Within these structures, signal complexity was also reduced in a subset of frontal regions. Neurobehavioral effects of acute alcohol consumption may be partially driven by disruption of intraregional neural dynamics among regions involved in higher‐order cognitive and attentional processes.
Ethanol and Cannabinoids Regulate Zebrafish GABAergic Neuron Development and Behavior in a Sonic Hedgehog and Fibroblast Growth Factor‐Dependent Mechanism
Authors: Boa‐Amponsem Oswald , Zhang Chengjin , Burton Derek , Williams Kevin P. , Cole Gregory J. 
Published: May 2020

BackgroundEthanol (EtOH) has diverse effects on nervous system development, which includes development and survival of GABAergic neurons in a sonic hedgehog (Shh) and fibroblast growth factor (Fgf)‐dependent mechanism. Cannabinoids also function as inhibitors of Shh signaling, raising the possibility that EtOH and cannabinoids may interact to broadly disrupt neuronal function during brain development.MethodsZebrafish embryos were exposed to a range of EtOH and/or cannabinoid receptor 1 (CB1R) agonist concentrations at specific developmental stages, in the absence or presence of morpholino oligonucleotides that disrupt shh expression. In situ hybridization was employed to analyze glutamic acid decarboxylase (gad1) gene expression as a marker of GABAergic neuron differentiation, and zebrafish behavior was analyzed using the novel tank diving test as a measure of risk‐taking behavior.ResultsCombined acute subthreshold EtOH and CB1R agonist exposure results in a marked reduction in gad1 mRNA expression in zebrafish forebrain. Consistent with the EtOH and cannabinoid effects on Shh signaling, fgf8 mRNA overexpression rescues the EtOH‐ and cannabinoid‐induced decrease in gad1 gene expression and also prevents the changes in behavior induced by EtOH and cannabinoids.ConclusionsThese studies provide evidence that forebrain GABAergic neuron development and zebrafish risk‐taking behavior are sensitive to both EtOH and cannabinoid exposure in a Shh‐ and Fgf‐dependent mechanism, and provide additional evidence that a signaling pathway involving Shh and Fgf crosstalk is a critical target of EtOH and cannabinoids in FASD.
It is currently unknown whether SARS‐CoV‐2 is viable in semen or whether COVID‐19 damages spermatozoa
Authors: Perry Melissa J. , Arrington Suzanne , Neumann Laura M. , Carrell Douglas , Mores Christopher N. 
Published: May 2020

AbstractResearch is needed to understand the presence of the SARS‐CoV‐2 virus in semen, sexual transmissibility, and impact on sperm quality. Several studies have examined men recovering from COVID‐19, but large‐scale community‐based testing is needed to ascertain the effects on the male reproductive tract, and the potential for prolonged transmission.
Visual‐motor functions are affected in young adults who were born premature and screened for retinopathy of prematurity
Authors: Pétursdóttir Dýrleif , Holmström Gerd , Larsson Eva , Böhm Birgitta 
Published: May 2020

AbstractAimTo assess visual‐motor integration in young adults previously included in a prospective study on the incidence of retinopathy of prematurity (ROP).MethodsThe study encompassed 59 preterm individuals, born 1988‐1990, with a birth weight ≤1500 g, and 44 full‐term controls, aged 25‐29 years. Ophthalmological examination, including visual acuity and contrast sensitivity, and the Beery Visual‐Motor Integration (VMI) with supplemental tests of visual perception and motor coordination, were performed. A short questionnaire was filled in.ResultsThe preterm individuals had significantly lower scores than the controls in all VMI tests, median values and interquartile ranges: Beery VMI 87 (21) vs 103 (11), visual perception 97 (15) vs 101 (8) and motor coordination 97 (21) vs 102 (15), respectively. Within the preterm group, no correlations were found between the VMI tests and ROP, gestational age, birth weight or visual acuity. Contrast sensitivity was correlated to visual perception. Neurological complication at 2.5 years was a risk factor for lower scores on Beery VMI. The preterm subjects reported six times as many health problems as compared to the controls.ConclusionBeing born preterm seemed to have life‐long effects. This study shows that visual‐motor integration was affected in young adults born preterm.
Opportunities for changes in the drug product design to enhance medication safety in older people: Evaluation of a national public portal for medication incidents
Authors: Karapinar‐Çarkit Fatma , van den Bemt Patricia M.L.A. , Sadik Mariam , van Soest Brigit , Knol Wilma , van Hunsel Florence , van Riet‐Nales Diana A. 
Published: May 2020

AimsMedication safety requires urgent attention in hospital pharmacy. This study evaluated the medication‐related problems/errors as reported to the Dutch medication incident registry and disseminated for information to pharmacists. Through analysis by an expert panel we aimed to better understand which problems could have been mitigated by the drug product design. Additionally, the (wider) implications of the problems for current hospital/clinical practice were discussed.MethodsItems were extracted from the public Portal for Patient Safety. Items were included if relevant for older people and connected with the drug product design and excluded if they should reasonably have been intercepted by compliance to routine controls or well‐known professional standards in pharmaceutical care. To explore any underreporting of well‐known incidents, it was investigated if different medication‐related problems could be observed in a regional hospital practise over a 1‐month period. For 6 included items (cases), the implications for hospital/clinical practise were discussed in an expert panel.ResultsIn total, 307 items were identified in the Portal for Patient Safety; all but 14 were excluded. Six cases were added from daily hospital practice. These 20 cases commonly related to confusing product characteristics, packaging issues such as the lack of a single unit package for an oncolytic product, or incorrect or incomplete user instructions.ConclusionMedication registries provide important opportunities to evaluate real‐world medication‐related problems. However, underreporting of well‐known problems should be considered. The product design can be used as an (additional) risk mitigation measure to support medication safety in hospital practice.
Potential dual functional roles of the Y‐linked RBMY in hepatocarcinogenesis
Authors: Kido Tatsuo , Tabatabai Z. Laura , Chen Xin , Lau Yun‐Fai Chris 
Published: May 2020

AbstractHepatocellular carcinoma (HCC) is a highly heterogeneous liver cancer with significant male biases in incidence, disease progression, and outcomes. Previous studies have suggested that genes on the Y chromosome could be expressed and exert various male‐specific functions in the oncogenic processes. In particular, the RNA‐binding motif on the Y chromosome (RBMY) gene is frequently activated in HCC and postulated to promote hepatic oncogenesis in patients and animal models. In the present study, immunohistochemical analyses of HCC specimens and data mining of The Cancer Genome Atlas (TCGA) database revealed that high‐level RBMY expression is associated with poor prognosis and survival of the patients, suggesting that RBMY could possess oncogenic properties in HCC. To examine the immediate effect(s) of the RBMY overexpression in liver cancer cells, cell proliferation was analyzed on HuH‐7 and HepG2 cells. The results unexpectedly showed that RBMY overexpression inhibited cell proliferation in both cell lines as its immediate effect, which led to vast cell death in HuH‐7 cells. Transcriptome analysis showed that genes involved in various cell proliferative pathways, such as the RAS/RAF/MAP and PIP3/AKT signaling pathways, were downregulated by RBMY overexpression in HuH‐7 cells. Furthermore, in vivo analyses in a mouse liver cancer model using hydrodynamic tail vein injection of constitutively active AKT and RAS oncogenes showed that RBMY abolished HCC development. These findings support the notion that Y‐linked RBMY could serve dual tumor‐suppressing and tumor‐promoting functions, depending on the spatiotemporal and magnitude of its expression during oncogenic processes, thereby contributing to sexual dimorphisms in liver cancer.
Biological evaluation of Keggin‐type polyoxometalates on tyrosinase: Kinetics and molecular modeling
Authors: Chi Guoxiang , Xie Lefang , Zhao Meijuan , Wang Li , Wang Fang , Li Jian , Zheng Aping 
Published: May 2020

AbstractAbnormal overexpression of tyrosinase activity can lead to the production of hyperpigmentation in human skin and enzymatic browning in fruits and vegetables. Herein, the inhibition and mechanism of the H3PMo12O40 and two transition metal‐substituted Keggin‐type polyoxometalates (Na7PMo11CoO40 and Na7PMo11ZnO40) on tyrosinase were studied by kinetics and molecular modeling. Kinetic studies indicated that all compounds had more potent inhibitory activities than standard arbutin, and H3PMo12O40 (IC50 = 0.443 ± 0.006 mm) is ~15‐fold stronger inhibition than arbutin. Additionally, all compounds inhibited tyrosinase in a reversible competitive manner. Intriguingly, molecular modeling elucidated that three compounds competitively bind to tyrosinase mainly through more interactions with Cu2+ ions and the amino acid residue capable of forming cation‐π and hydrogen bonding, forming a reversible non‐covalent complex. Molecular simulation study correlated well with the biological activity of three compounds in vitro. This work provided new insights into design and synthesis of polyoxometalates as tyrosinase inhibitors in the field of medicine, cosmetic, and food.
MECP2 mutation spectrum and its clinical characteristics in a Chinese cohort
Authors: Wen Yongxin , Wang Jiaping , Zhang Qingping , Chen Yan , Wu Xiru , Bao Xinhua 
Published: May 2020

AbstractThe dysfunction of methyl‐CpG‐binding protein 2 (MeCP2) is associated with several neurological disorders, of which Rett syndrome (RTT) is the most prominent. This study focused on a Chinese patient cohort with MECP2 mutations, and analyzed the characteristics of these mutations and their clinical manifestations. In total, 666 patients were identified with 126 different MECP2 mutations, including 22 novel mutations. Over 80% of patients carried an MECP2 mutation on exon 4. Nonsense and missense mutations were the most commonly reported types. Missense mutations were mainly located on methyl‐CpG‐binding domain (MBD), and nonsense mutations predominantly occurred on transcription repression domain (TRD) and inter domain. The predilection site of large deletion was exon 3 and/or exon 4. Patients with p.R133C, p.R294*, p.R306C, and C‐terminal domain (CTD) deletions were less severely affected. Significant differences were found in ambulation ability, hand function, and language among different mutation groups. Three female patients with MECP2 mutations (1 with p.R306P and 2 with p.R309W) only presented with intellectual disability/developmental delay (ID/DD), and no obvious RTT symptoms were reported. Eight male individuals with MECP2 mutations were also identified in this study, including 2 diagnosed with typical RTT, 3 with atypical RTT and 3 with ID/DD.