bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Iranian Version of the Hospital Ethical Climate Survey
Authors: Rivaz Mozhgan , Rakhshan Mahnaz , Vizeshfar Fatemeh , Setoodegan Elahe 
Published: March 2020

Background and PurposeThe aim of this study was to determine validation of the Iranian version of the Hospital Ethical Climate Survey (HECS).MethodsThis is a methodological study with a cross-sectional design that was conducted in 2016. A forward–backward translation method was used to translate the questionnaire from English to Persian and face, content, and construct validity as well as reliability were assessed.ResultsThe factor structure of the HECS through explorative Principal Component Analysis (PCA) confirmed five factors that explained 64.7% of total variance. The overall Cronbach's alpha coefficient was .86 and the Cronbach's alphas for five of the subscales were between .63 and .92.ConclusionsThe Iranian version of HECS has adequate validity and reliability for measuring the hospital ethical climate in the Iraniansociety.
Validation of the Arabic Version of the Brief Symptom Inventory to Measure Anxiety in Patients With Acute Myocardial Infarction
Authors: Al-Dweik Ghadeer , Eid AbuRuz Mohannad 
Published: March 2020

Background and PurposeAnxiety after acute myocardial infarction is well-known phenomenon. This study aimed to examine the psychometric properties of the Arabic version of the Brief Symptom Inventory to measure anxiety in this population.MethodsThis was a prospective observational study among 460 patients. Patients answered the Brief Symptom Inventory and the Hospital Anxiety and Depression Scale to measure anxiety. Complications and other clinical variables abstracted from medical records.ResultsCronbach's α was .86, indicating adequate internal consistency. The item-total correlations and all interitem correlations were all acceptable. Anxiety was independent predictor for complication after acute myocardial infarction and higher in females supporting the construct validity.ConclusionArabic version of the Brief Symptom Inventory is a valid and reliable instrument to measure anxiety after acute myocardial infarction.
Percepção da equipe multiprofissional infanto-juvenil cardiovascular sobre a integralidade
Authors: Silva Cristiane Pinto , Medeiros Thaize Sousa , Santos Roseana Gomes Leal dos 
Published: March 2020

O objetivo desse artigo foi analisar a percepção da equipe multidisciplinar em relação ao princípio da integralidade no atendimento infanto-juvenil na Fundação Pública Estadual Hospital de Clínicas Gaspar Vianna – FPHCGV, referência em serviços de cardiopediatria em Belém, no Estado do Pará. Realizou-se estudo qualitativo, utilizando-se entrevistas semiestruturadas. A sistematização e a interpretação dos dados foram realizados pela análise de conteúdo definida por Minayo1 (2008). Os resultados do estudo apontaram lacunas na efetivação da assistência integral destinada ao público infanto-juvenil nos serviços de saúde, conforme revelado nas falas dos profissionais, além das dificuldades ao acesso à rede de serviços de cardiopediatria, a falta de assistência ao familiar no período de hospitalização que ocasiona empecilhos e repercussões no cuidado desses sujeitos, a falta de infraestrutura para efetivação do atendimento aos usuários considerando as peculiaridades destes, assim como, à falta de diálogo entre os membros da equipe e a não participação nas atividades em grupo, além da constatação da presença do modelo hospitalocêncrico presente em detrimento da prática interdisciplinar nas instituições de saúde.
O bolsa família
Authors: Sousa Karla Kaliane de Moura 
Published: March 2020

O livro O Bolsa Família: verso e reverso é fruto de um projeto de pesquisa denominado Programas de Transferência de Renda Condicionada na América Latina que permite um estudo comparado - Bolsa Família (Brasil), Nuevo Régimen de Asignaciones Familiares (Uruguai) e Asignación Universal por Hijo para la Protección Social (Argentina). Trata-se de uma cooperação acadêmico-cientifica financiada pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) envolvendo o Programa de Pós-Graduação em Políticas Públicas da Universidade Federal do Maranhão, os Programas de Pós-Graduação em Serviço Social da Pontifícia Universidade Católica de São Paulo e da Pontifícia Universidade Católica do Rio Grande do Sul, o Programa de Doctorado en Ciencias Sociales de la Faculdad de Ciencias Sociales da Universidade de la Republica do Uruguai e do Mestrado en Ciencias Sociales de la Faculdad de Ciencias Humanas da Universidad Nacional del Centro de la Provincia de Buenos Aires, Argentina.
Aktivitas Antibakteri dan Stabilitas Sediaan Gel Minyak Atsiri Daun Jeruk Purut (Citrus hystrix folium)
Authors: Les Luky Hayuning , Isnaeni Isnaeni , Soeratri Widji 
Published: March 2020

Pendahuluan: Daun jeruk (Citrus hystrix folium) mengandung minyak esensial 1-1,5%, menunjukkan aktivitas antibakteri. Bahan aktif yang berkontribusi sebagai aktivitas antibakteri mengandung senyawa dengan gugus alkohol dan aldehida yang mendenaturasi protein sel bakteri. Tujuan: mengevaluasi efektivitas dan stabilitas antibakteri gel yang mengandung minyak esensial hasil isolasi dari daun Citrus hystrix terhadap Staphylococcus epidermidis dan Staphylococcus aureus. Metode: Formulasi gel minyak atsiri dibuat menggunakan karbomer 940 sebagai gelling agent. Aktivitas antibakteri gel yang mengandung minyak atsiri dievaluasi terhadap Staphylococcus epidermidis dan Staphylococcus aureus dengan gel yang mengandung 1% klindamisin sebagai kontrol positif dengan metode difusi agar. Hasil: Sediaan Gel efektif terhadap Staphylococcus epidermidis dan Staphylococcus aureus. Diameter rata-rata zona hambatan pertumbuhan sebelum dan sesudah penyimpanan selama 4 minggu adalah 16,75 mm, dan 17,65 mm. Aktivitas hambatan terhadap dua bakteri uji relatif lebih kecil daripada gel klindamisin. Gel memiliki stabilitas fisik yang baik ditunjukkan dengan tidak adanya perubahan pada konsistensi, warna, bau, viskositas dan pH yang diamati selama penyimpanan 4 minggu. Gel menghasilkan warna putih kekuningan dan bau jeruk yang khas, sedangkan gel kontrol menunjukkan warna kuning transparan dan berbau tween. Kesimpulan: Gel minyak atsiri jeruk secara efektif menghambat pertumbuhan Staphylococcus epidermidis dan Staphylococcus aureus, stabil setelah penyimpanan selama 4 minggu, oleh karena itu prospektif untuk dikembangkan sebagai bahan baku untuk gel anti jerawat.
A Comparison of Contiguous Two-level Anterior Cervical Discectomy and Fusion using a Structural Allograft versus a Polyetheretherketone (PEEK) Cage: The Results of a Three-Year Follow-up
Authors: MOO ING HOW , Kam Carmen Jia Wen , Lai Maksim Wen Sheng , Yeo William , Soh Reuben Chee Cheong 
Published: March 2020

Abstract
Background: Allografts and polyetheretherketone (PEEK) cages are the two most commonly used material in anterior cervical discectomy and fusion (ACDF). However, their effectiveness in in two-level ACDF remains controversial. The primary aim of this retrospective study is to compare the clinical and radiological outcomes of two-level ACDF with plate fixation using either a structural allograft or a PEEK cage.
Methods: From 2010 to 2015, 88 consecutive patients underwent a two-level ACDF of which 53 used an allograft and 35 patients with a PEEK cage. All PEEK cages were filled with local autografts. All clinical outcomes were prospectively collected preoperatively, at six months and at two years after surgery. Clinical efficacy was evaluated using visual analogue scale for neck pain and limb pain, the Neck Pain and Disability Score, Neck Disability Index, Neurogenic Symptom Score, and the Japan Orthopedic Association score. Radiological outcomes were assessed preoperatively, immediately after surgery, and at the final follow-up.

Results: A preoperative comparison revealed no difference between the two patient groups in terms of age, gender, body mass index, smoking status, preoperative symptoms, operated levels, and follow-up (mean= 42.8 months). No difference in improvements in the clinical outcome between the two groups was observed. Both groups showed significant improvement in mean disc height, segmental height, and segmental lordosis postoperatively. The fusion rates for PEEK cage was 100% at both levels while the fusion rates for allograft group was 98.1% at cephalad level and 94.2% at caudad level (p>0.05). Subsidence at the cephalad level occurred in 22.9% (8/35) segments in the PEEK group and 7.7% (4/52) segments in the allograft group (p=0.057). At the caudal level, a higher cage subsidence was noted in the PEEK group compared to the allograft group [37.1% (13/35) versus 15.4% (8/52)] (p=0.02). Overall, subsidence was noted in 30% (21/70) of the PEEK group and in 11% (12/104) of the allograft group (p<0.05).
Conclusion: The use of PEEK cages resulted in a higher rate of subsidence in two-level ACDF as compared to allograft. Two-level ACDF using either allografts or PEEK cages resulted in similar clinical outcomes, radiological improvements in alignment and fusion rates.
Incidence and Predictors of Tuberculosis Occurrence among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, Northwest Ethiopia: Retrospective Follow-up Study
Authors: Aemro Agazhe , Jember Abebaw , Anlay Degefaye Zelalem 
Published: March 2020

Abstract
Background : In resource limited settings, Tuberculosis (TB) is a major cause of morbidity and mortality among patients on antiretroviral treatment. Ethiopia is one of the 30 high TB burden countries. TB causes burden in healthcare system and challenge the effectiveness of HIV care. This study was to assess incidence and predictors of Tuberculosis among adults on antiretroviral therapy at Debre Markos Referral Hospital, Northwest Ethiopia, 2019. Methods : Institution based retrospective follow up study was conducted among adults on ART newly enrolled from 2014 to 2018 at Debre Markos Referral Hospital. Simple random sampling technique was used to select patients chart. Data was entered to EPI- INFO version 7.2.2.6 and analyzed using Stata 14.0. Tuberculosis incidence rate was computed and described using frequency tables. Both bivariable and multivariable Cox proportional hazard models was fitted to identify predictors of TB. Results : Out of the 536 patients chart reviewed, 494 patient records were included in the analysis. A total of 62 patients developed new TB cases during the follow up period of 1000.22 Person Years (PY); which gives an overall incidence rate of 6.19 cases per 100 PY (95% CI: 4.83 - 7.95). The highest rate was seen within the first year of follow up. After adjustment base line Hemoglobin < 10 g/dl (AHR= 5.25; 95% CI: 2.52 - 10.95), ambulatory/bedridden patients at enrolment (AHR = 2.31; 95% CI: 1.13 - 4.73), having fair or poor ART adherence (AHR = 3.22; 95% CI: 1.64 – 6.31) were associated with increased risk of tuberculosis whereas taking Isoniazid Preventive Therapy (IPT) (AHR = 0.33; 95% CI: 0.12 - 0.85) were protective factors of TB occurrence. Conclusion : TB incidence was high among adults on ART especially in the first year of enrollment to ART. Low hemoglobin level, ambulatory or bedridden functional status, non-adherence to ART and IPT usage status were found to be independent predictors. Hence, continuous follow up for ART adherence and provision of IPT has a great importance to reduce the risk of TB.
Adolescents’ Perception Of Dietary Behaviour In A Public School In Chile: A Focus Groups Study
Authors: Vio Fernando , Olaya Marcela , Yañez Marisol , Montenegro Edith 
Published: March 2020

Abstract
Background: The objective of this study was to assess dietary behavior among sixth- to eighth-grade students to inform the delivery and content of nutrition education. Methods: This was a qualitative study through focus groups. Subjects were 57 adolescents 10-14 years old, 30 males and 27 females distributed in six groups. To compare group responses, transcriptions were coded using the original question guide. The information was analyzed using the content analysis technique. Results: The main findings showed that adolescents knew dietary guidelines, but they consumed non-healthy food. They liked to cook but preferred fast food preparations. They increased fast food consumption on weekends and with friends. In utilization of Information Communication Technologies (ICT), all students had access to technology through mobile phones, tablets and computers and were open to have an interactive program with personal information about diet and behavior. Conclusions: Adolescents dietary behavior is not healthy and can be changed with interactive programs considering participation, personal information and utilizing ICT. Keywords: adolescents, community health promotion, dietary behavior, qualitative methods, focus groups
Prevalence of postpartum depression and associated factors among postnatal care attendees in Debre Berhan, Ethiopia, 2018.
Authors: wubetu abate Dargie , Engidaw Nigus Alemnew , Gizachew Kefyalew Dagne 
Published: March 2020

Abstract
Background: Postpartum depression explains various groups of depressive symptoms and syndromes that can take place during the first 6 weeks following birth. The postpartum period is a critical time where both mild and severe mood disorders can occur. The familiar forms are baby blues and postpartum depression. Understanding the prevalence and associated factors of postpartum depression is mandatory for early detection and treatment.
Methods: Institution based cross-sectional study was conducted from 1st May to June 30, 2018. The study participants were eligible women who came to Debre Berhan referral hospital and health centers for postnatal care and vaccination service. The Edinburgh postnatal depression scale was used to assess postpartum depression. A systematic random sampling technique was used to collect the data after determining the skip fraction (k=2). The collected data were coded and entered into Epi-info version 7 and transported to SPSS version 20 for analysis. Both bivariate and multivariate binary logistic regression were done to identify associated factors. During bivariate analysis, variables with p-value < 0.05 were included in multivariate analysis. Odds ratios and their 95% confidence intervals were computed and variables with p-value less than 0.05 were considered to declare significantly associated factors (multivariate analysis).
Putting RFMix and ADMIXTURE to the test in a complex admixed population
Authors: Uren Caitlin , Hoal Eileen G. , Möller Marlo 
Published: March 2020

Abstract
Background
Global and local ancestry inference in admixed human populations can be performed using computational tools implementing distinct algorithms. The development and resulting accuracy of these tools has been tested largely on populations with relatively straightforward admixture histories but little is known about how well they perform in more complex admixture scenarios.
Results
Using simulations, we show that RFMix outperforms ADMIXTURE in determining global ancestry proportions even in a complex 5-way admixed population, in addition to assigning local ancestry with an accuracy of 89%. The ability of RFMix to determine global and local ancestry to a high degree of accuracy, particularly in admixed populations provides the opportunity for more accurate association analyses.
Conclusion
This study highlights the utility of the extension of computational tools to become more compatible to genetically structured populations, as well as the need to expand the sampling of diverse world-wide populations. This is particularly noteworthy as modern-day societies are becoming increasingly genetically complex and some genetic tools and commonly used ancestral populations are less appropriate. Based on these caveats and the results presented here, we suggest that RFMix be used for both global and local ancestry estimation in world-wide complex admixture scenarios particularly when including these estimates in association studies.
Third molar agenesis in modern humans with and without agenesis of other teeth
Authors: Scheiwiller Maya , Oeschger Elias S. , Gkantidis Nikolaos 
Published: March 2020

Abstract
Background The number of teeth in the human dentition is of interest both from developmental and evolutionary aspects. The present case-control study focused on the formation of third molars in modern humans aiming to shed more light on the most variable tooth class in the dentition. Methods For this reason, we investigated third molar formation in a sample of 303 individuals with agenesis of teeth other than third molars (agenesis group) and compared it to a sex and age matched control group of 303 individuals without agenesis of teeth other than third molars. Results The prevalence of third molar agenesis in the agenesis group was 50.8%, which is significantly higher than the 20.5% in the control group (p < 0.001). The chance of a missing third molar in the agenesis group was increased by 38.3% (p < 0.001), after controlling for the agenesis in other teeth factor. When considering the amount of missing third molars per individual, a clear tendency towards more missing third molars was evident in the agenesis group compared to the control group. The frequency of bilaterally missing third molars in the agenesis group was 29% in the maxilla, as well as in the mandible, which is about three times higher than the frequency of unilaterally missing third molars (p < 0.001). In the control group, bilaterally missing third molars occurred in 8.6% in the maxilla and 8.9% in the mandible. Conclusion The present results indicate that genetic factors involved in tooth agenesis affect also the dentition as a whole. Furthermore, the third molars are more vulnerable to factors involved in agenesis of other teeth and they are more often affected as a whole. These findings seem to be associated with the evolutionary trend in humans towards reduced molar number.
Lenticulostriate arteries appearance before thrombectomy predicts good outcome in acute middle cerebral artery occlusion
Authors: Liu Feifeng , Chen Chen , Hong Lan , Shen Hao , Cao Wenjie , Dong Qiang , Yang Xinyi , Guo Mengruo , Li Ying , Xiao Yaping , Cheng Xin , Li Gang 
Published: March 2020

Abstract
Purpose Endovascular therapy is widely used in acute large vessel occlusion. This study investigated whether imaging of lateral lenticulostriate arteries(LSAs) before thrombectomy would potentially be helpful for predicting prognosis of patients with acute M1 segment of middle cerebral artery occlusion(MCAO). Methods 59 consecutive patients with acute M1 segment of MCAO treated with mechanical thrombectomy at two comprehensive stroke center were analyzed. Patients were categorized into LSA+ (appearing of lateral LSAs) and LSA- (sparing of lateral LSAs) group according to preprocedural digital substraction angiography (DSA).Baseline data and clinical outcomes were compared. A good clinical outcome was defined as a modified Rankin Scale score of 0 to 2 at 3 months. The association between clinical and imaging parameters and functional outcome was evaluated with logistic regression analysis. Results LSA+ was shown in 36 patients (61%). LSA+ group had a significantly higher proportion of good outcome (72.2% vs. 8.7%, OR 27.3,95% CI 5.38-138.4, P <0.001), lower risk of symptomatic intracranial haemorrhages (sICH) (8.3% vs. 47.8%,OR 0.10,95% CI 0.02-0.42, P =0.001) and lower mortality in hospital (5.6% vs. 34.8%, OR 0.11,95% CI 0.02 -0.58, P <0.004) compared with LSA- group. Patients in LSA+ group had lower baseline NIHSS score( P <0.01) and NIHSS score at 14 days( P <0.01) and smaller infarct core volume( P =0.016) on computed tomography perfusion imaging (CTP) compared to the LSA- group. Multivariate logistic regression analysis showed that a small infarct core volume (OR 6.74,95% CI 1.148-39.569, P =0.035) and LSA+(OR 22.114,95% CI 3.339-146.470, P =0.001) were associated with a good clinical outcome. Conclusions Our data suggest that appearance of lateral LSAs before mechanical thrombectomy would be potentially helpful for predicting favorable prognosis of patients with acute M1 segment of MCAO.
Urinary continence outcomes of four years of follow-up and predictors of early and late urinary continence in patients undergoing robot-assisted radical prostatectomy
Authors: Li Xing , Zhang Huan , Jia Zhuo , Wang Yunpeng , Song Yong , Liao Limin , Zhang Xu 
Published: March 2020

Abstract
Background: The robot-assisted radical prostatectomy (RARP) has been widely applied in recent years; however, only a few studies are reported about long-term urinary continence after surgery. The present study aimed to examine the outcomes of continence rates (CRs) and determine the risk and protective factors of urinary continence in patients with prostate cancer (PCa) undergoing RARP. Methods: This retrospective study included 650 patients treated with RARP with perioperative data and at least one year of follow-up from January 2009 to November 2017. Also, the preoperative, intraoperative, and postoperative parameters of the patients were analyzed. Continence was defined as no pad use. Early and late continence was defined as the return of urinary continence within 3 months and beyond 12 months post-surgery, respectively. CRs were examined from 1–48 months postoperatively. Logistic regression analysis evaluated the association between the predictive factors and urinary continence in the early and late stages. Results: No significant difference was detected in the CR from 12–48 months postoperatively (P=0.766). Logistic regression analysis proved that pelvic lymph node dissection (PLND) was a significant risk factor of urinary continence at 1 month. Nerve-sparing (NS) was a significant protective factor of urinary continence at 1, 3, and 6 months. Advanced age was an independent risk factor of urinary continence at 6, 12, and 24 months. Other variables were not statistically significant predictors of urinary continence. Conclusions: The current results demonstrated that CR gradually improved with time within 1 year and stabilized 1 year after the surgery. PLND, NS, and age were significant determinants of continence in the early and late stages, respectively. These parameters could be used for preoperative identification of patients at high risk and counseling about postoperative expectations for urinary continence.
LncRNA MALAT1 exhibits positive effects on nucleus pulposus cell biology in vivo and in vitro by sponging miR-503
Authors: Zheng Hongyu , Wang Tingting , Li Xiangmin , He Wei , Gong Zhiqiang , Lou Zhenkai , Wang Bing , Li Xingguo 
Published: March 2020

AbstractBackground: Intervertebral disc degeneration (IDD) is characterized by the loss of nucleus pulposus cells (NPCs) and phenotypic abnormalities. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are involved in the pathogenesis of IDD. In this study, we aimed to investigate the functional effects of lncRNA MALAT1 on NPCs in IDD and the possible mechanism governing these effects. Results: We validated the decreased expression of MALAT1 in the IDD tissues, which was associated with decreased Collagen II and Aggrecan expression. In vitro, overexpressed MALAT1 could attenuate the effect of IL-1β on NPC proliferation, apoptosis, and Aggrecan degradation. In vivo, MALAT1 overexpression attenuated the severity of disc degeneration in IDD model rats. Our molecular study further demonstrated that MALAT1 could sponge miR-503, modulate the expression of miR-503, and activate downstream MAPK signaling pathways. The effects of MALAT1 on NPCs were partially reversed/aggregated by miR-503 mimics/inhibitor treatment. Conclusion: Our data suggested that the MALAT1-miR-503-MAPK pathway plays a critical role in NPCs, which may be a potential strategy for alleviating IDD.