bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflection point in the power spectrum of stellar brightness variations
Authors: Amazo-Gómez E. M. , Shapiro A. I. , Solanki S. K. , Kopp G. , Oshagh M. , Reinhold T. , Reiners A. 
Published: September 2020

Context. Stellar rotation periods can be determined by observing brightness variations caused by active magnetic regions transiting visible stellar disk as the star rotates. Successful stellar photometric surveys stemming from the Kepler and TESS observations have led to the determination of rotation periods in tens of thousands of young and active stars. However, there is still a lack of information on the rotation periods of older and less active stars like the Sun. The irregular temporal profiles of light curves caused by the decay times of active regions, which are comparable to, or even shorter than, stellar rotation periods, in combination with the random emergence of active regions make period determination for such stars very difficult.
Aims. We tested the performance of a new method for the determination of stellar rotation periods against stars with previously determined rotation periods. The method is based on calculating the gradient of the power spectrum (GPS) and identifying the position of the inflection point (i.e. point with the highest gradient). The GPS method is specifically aimed at determining rotation periods of low-activity stars like the Sun.
Methods. We applied the GPS method to 1047 Sun-like stars observed by the Kepler telescope. We considered two stellar samples individually: one with near-solar rotation periods (24–27.4 d) and a broad range of effective temperatures (5000–6000 K) and the other with near-solar effective temperatures (5700–5900 K) and a broad range of rotation periods (15–40 d).
Results. We show that the GPS method returns precise values for stellar rotation periods. Furthermore, it allows us to constrain the ratio between facular and spot areas of active regions at the moment of their emergence. We also show that the relative facular area decreases with the stellar rotation rate.
Conclusions. Our results suggest that the GPS method can be successfully applied to retrieve the periods of stars with both regular and non-regular light curves.
Case report: Infant with a Fast-growing Soft Tissue Tumor on the
Thumb, Revealing a PLAG1-positive Connatal Lipoblastoma
Authors: Deeg Susanne , Wessel Lucas , Martel Richard , Porubsky Stefan , Svoboda Daniel 
Published: September 2020

AbstractAt the age of 4 months, an infant was presented to us with a nodular subcutaneous
tumor on the right thumb measuring 2cm, already seen prenatally via ultrasound.
An MRI in sedation performed at the age of 4.5 months had no diagnostic
specificity. By a biopsy at the age of 5 months malignancy could be excluded.
Finally at the age of 16 months the tumor which had meanwhile grown to a
monstrous size (5 cm of diameter) could be entirely removed by
microsurgical technique maintaining the integrity of all intrinsic structures.
The diagnosis of myxoid lipoblastoma was confirmed. According to literature,
Lipoblastomas often present as connatal rapid growing soft tissue tumors and are
benign. Total removal is essential for avoiding a local recurrence.
Development and Validation of a Stability Indicating LC-MS/MS Method for the Determination of Clenbuterol HCl
Authors: Prajapati Krunal J. , Kothari Charmy 
Published: September 2020

AbstractClenbuterol hydrochloride (CLT), β2 adrenergic agonist is used as a bronchodilator in the therapeutic treatment of asthma. It is important to know the stability behaviour of the drug in different degradation conditions as per ICH Q1A (R2) guidelines for safety and efficacy purpose. The main objective of the study is to develop and validate stability indicating LC-MS/MS method for the determination of Clenbuterol HCl. The separation was achieved using Phenomenex Gemini NX C18 (250*4.6 mm, 5 μ) column and the mobile phase consisting of ammonium acetate buffer (5 mM), 0.15% triethylamine (TEA), pH 7.5 with acetic acid: methanol (70:30, v/v) at flow rate 1 ml/min. The detection was done using PDA detector at 245 nm. The validation was performed as per ICH Q2 (R1) guideline. The drug was subjected to stress degradation conditions as per ICH Q1A (R2) guidelines. The significant degradation was observed in acidic (8.78%) and sunlight (liquid) (9%) condition while no degradation was observed in neutral, basic, oxidation and thermal condition. The drug and its degradation products were characterized using LC-MS/MS and the proposed degradation mechanism was communicated. The developed method was found to be stability-indicating, simple, specific, selective, sensitive, linear, accurate, robust and precise and used as a routine analysis in quality control laboratory.
Ist die kieferorthopädische Korrektur einer wachsenden hyperdivergenten retrognathen Klasse II möglich?
Authors: Buschang Peter H. 
Published: September 2020

ZusammenfassungEin großer Teil der Klasse-II-Fälle ist retrognath und hyperdivergent. Viele zeigen ein ungünstiges Wachstumsmuster, durch das sich die anteroposterioren, die vertikalen und die transversalen skelettalen Beziehungen immer weiter verschlechtern. Mit den bisherigen Behandlungsstrategien ließen sich zwar die dentalen Beziehungen korrigieren, bei den skelettalen Problemen waren sie jedoch wenig effektiv. Bei der Behandlung der dentalen und der skelettalen Probleme ist es daher wichtig, den Unterkiefer nach vorne zu rotieren, anstatt ihn nach vorne zu überstellen. Eine echte Rotationsbewegung der Mandibula nach vorne, durch die bei wachsenden Kindern hauptsächlich die Projektion des Kinns bestimmt wird, lässt sich am besten durch absolute oder relative Intrusion der Zähne durchführen. Dies führt bei Kindern im Wachstum zu einer stärkeren Kinnprojektion, zu einem verbesserten Skelettprofil, zur Verkleinerung von Grund- und Kieferwinkeln und zur Verringerung der vorderen unteren Gesichtshöhe. Die mit diesem Verfahren erreichten orthopädischen Veränderungen sind vergleichbar mit oder sogar besser als die Ergebnisse, die kieferorthopädisch mit skelettaler Verankerung oder chirurgisch bei Erwachsenen erreicht werden. Das Verfahren scheint außerdem zu stabileren Ergebnissen zu führen als die Behandlung erwachsener Patienten, da hier mit und nicht gegen das Wachstum gearbeitet wird.
„Er hat verstanden, welche Verantwortung er trägt.“
Authors: Brodersen Folke 
Published: September 2020

ZusammenfassungEinleitung Mediale Darstellungen der Pädophilie ändern sich. Im Kontext von therapeutischen und Selbsthilfeangeboten entstehen seit Ende der 2000er-Jahre Repräsentationen kontrollierter Sexualität, die sich von Verwerfungen als „Monster“ und als „Bandenkrimineller“ unterscheiden.Forschungsziele Der Beitrag untersucht die Struktur und rekonstruiert die Bedingungen und Effekte des medialen Diskurses. Er fragt erstens nach Rhetoriken, die eine andere Repräsentation möglich erscheinen lassen. Zweitens diskutiert er, wie vor dem Hintergrund der historischen Abwertungen und Verwerfungen ein pädophiles Subjekt medial neu bzw. anders konstituiert werden kann.Methoden Untersuchungsgegenstand sind 33 Print- und audio(-visuelle) Reportagen, die pädophile Teilnehmende an therapeutischen und/oder Selbsthilfeangeboten porträtieren. Diese werden innerhalb der Phänomenstruktur der Grounded Theory analysiert.Ergebnisse In den medialen Repräsentationen wird Pädophilie ursächlich als Gefahr entworfen und zugleich negiert: Das Potential des sexuellen Kindesmissbrauchs wird ausgewiesen, erscheint aber als nicht zwingende Folge der sexuellen Disposition. Intervenierende Bedingung dafür ist die medizinische Rahmung als überzeitliche, unveränderbare Sexualität, mit der eine prekäre Patho-Normalisierung ebenso wie die Möglichkeit der Kontrolle auf der Handlungsebene einhergeht. Die Problemlösung der sexuellen Kontrolle wird in den Reportagen anhand von drei Subjektpositionen nachgezeichnet: der leidenden Seele auf dem Weg zur Therapie, dem vom eigenen Gewissen verfolgten Empathiker und dem herausgeforderten, sich aber aufopfernden Helden. Gesellschaftlich ergibt sich aus Mitgefühl und rationaler Abwägung eine Aufforderung zur Entstigmatisierung.Schlussfolgerung Der Beitrag rekonstruiert eine Gegen-Emotionalisierung und technokratische Kontrollversprechen als Entstehungsbedingungen eines neuen legitimen pädophilen Subjekts. Dieses konstituiert ein Gegenbild zu vorherigen Darstellungen, unternimmt eine teilweise Normalisierung und deutet in Teilen Idealisierungen des Pädophilen als Kindern besonders zugewandtem Subjekt an.
Die Gradierung in Bönninghausens Therapeutischem Taschenbuch
Authors: Schipflinger Guntmar , Lucae Christian 
Published: September 2020

ZusammenfassungDie unterschiedliche Gradierung verschiedener Autoren beginnend bei Bönninghausens Therapeutischem Taschenbuch (TB) bis hin zu den verschiedenen Software-Varianten wird tabellarisch gegenübergestellt und ausführlich kommentiert. Die Bedeutung des TB bleibt unbestritten und eine einheitliche Gradierung wäre wünschenswert.
Asymptomatic Females Are at Higher Risk for Perioperative TIA/Stroke and Males Are at Higher Risk for Long-Term Mortality after Carotid Artery Stenting: A Vascular Quality Initiative Analysis
Authors: Erben Young , Li Yupeng , Da Rocha-Franco Joao A. , Tawk Rabih G. , Barrett Kevin M. , Freeman William D. , Lin Michelle , Huang Josephine F. , Miller David , Farres Houssam , Brott Thomas G. , Meschia James F. , Hakaim Albert G. 
Published: September 2020

AbstractThe study aims to review the sex differences with respect to transient ischemic attack (TIA)/stroke and death in the perioperative period and on long-term follow-up among asymptomatic patients treated with carotid stenting (CAS) in the vascular quality initiative (VQI). All cases reported to VQI of asymptomatic CAS (ACAS) patients were reviewed. The primary end point was risk of TIA/stroke and death in the in-hospital perioperative period and in the long-term follow-up. The secondary end point was to evaluate predictors of in-hospital perioperative TIA/stroke and mortality on long-term follow-up after CAS. There were 22,079 CAS procedures captured from January 2005 to April 2019. There were 5,785 (62.7%) patients in the ACAS group. The rate of in-hospital TIA/stroke was higher in female patients (2.7 vs. 1.87%, p = 0.005) and the rate of death was not significant (0.03 vs. 0.07%, p = 0.66). On multivariable logistic regression analysis, prior/current smoking history (odds ratio = 0.58 [95% confidence interval or CI = 0.39–0.87]; p = 0.008) is a predictor of in-hospital TIA/stroke in females. The long-term all-cause mortality is significantly higher in male patients (26.9 vs. 15.7%, p < 0.001). On multivariable Cox-regression analysis, prior/current smoking history (hazard ratio or HR = 1.17 [95% CI = 1.01–1.34]; p = 0.03), coronary artery disease or CAD (HR = 1.15 [95% CI = 1.03–1.28]; p = 0.009), chronic obstructive pulmonary disease or COPD (HR = 1.73 [95% CI = 1.55–1.93]; p < 0.001), threat to life American Society of Anesthesiologists (ASA) class (HR = 2.3 [95% CI = 1.43–3.70]; p = 0.0006), moribund ASA class (HR = 5.66 [95% CI = 2.24–14.29]; p = 0.0003), and low hemoglobin levels (HR = 0.84 [95% CI = 0.82–0.86]; p < 0.001) are the predictors of long-term mortality. In asymptomatic carotid disease patients, women had higher rates of in-hospital perioperative TIA/stroke and a predictor of TIA/stroke is a prior/current history of smoking. Meanwhile, long-term all-cause mortality is higher for male patients compared with their female counterparts. Predictors of long-term mortality are prior/current smoking history, CAD, COPD, higher ASA classification of physical status, and low hemoglobin level. These data should be considered prior to offering CAS to asymptomatic female and male patients and careful risks versus benefits discussion should be offered to each individual patient.
A New Technique to Puncture and Remove a PTCA Balloon that Fails to Deflate
Authors: Pasamanickam Kannan , Rajadurai Jeyamalar , Choo Gim-Hooi 
Published: September 2020

AbstractWe present the first clinical report and describe the technique of using a modified Heartrail II guiding catheter to successfully puncture and remove a coronary angioplasty balloon that failed to deflate after stent implantation.
In Utero Vertical Transmission of Coronavirus Disease 2019 in a Severely Ill 29-week Preterm Infant
Authors: Gupta Arpit , Malhotra Yogangi , Patil Uday , Muradas Ana R. , Lee William T. , Krammer Florian , Amanat Fatima , Clare Camille A. , Vinod Suja , Ghaly Emad 
Published: September 2020

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-Cov-2) or coronavirus disease 2019 (COVID-19) is currently in worldwide pandemic state with very limited data about the mode of transmission to the growing fetus. There are a few published cases of COVID-19 infection in the infants born to COVID-19 positive mothers where most of the reported cases were either mildly symptomatic with positive COVID-19 polymerase chain reaction (PCR) or had negative COVID-19 PCR raising the question of vertical transmission. We present a case of likely intrauterine transmission of COVID-19 infection in a critically ill premature infant born to a COVID-19 infected mother and describing her clinical course thus far. The clinical presentation in the infant is consistent with COVID-19 infection described so far in literature along with positive PCR, and positive COVID-19 serology: immunoglobulin G, immunoglobulin M, and immunoglobulin A.
Registered Nurse Strain Detection Using Ambient Data: An Exploratory Study of Underutilized Operational Data Streams in the Hospital Workplace
Authors: Womack Dana M. , Hribar Michelle R. , Steege Linsey M. , Vuckovic Nancy H. , Eldredge Deborah H. , Gorman Paul N. 
Published: September 2020

Abstract
Background Registered nurses (RNs) regularly adapt their work to ever-changing situations but routine adaptation transforms into RN strain when service demand exceeds staff capacity and patients are at risk of missed or delayed care. Dynamic monitoring of RN strain could identify when intervention is needed, but comprehensive views of RN work demands are not readily available. Electronic care delivery tools such as nurse call systems produce ambient data that illuminate workplace activity, but little is known about the ability of these data to predict RN strain.
Objectives The purpose of this study was to assess the utility of ambient workplace data, defined as time-stamped transaction records and log file data produced by non-electronic health record care delivery tools (e.g., nurse call systems, communication devices), as an information channel for automated sensing of RN strain.
Methods In this exploratory retrospective study, ambient data for a 1-year time period were exported from electronic nurse call, medication dispensing, time and attendance, and staff communication systems. Feature sets were derived from these data for supervised machine learning models that classified work shifts by unplanned overtime. Models for three timeframes —8, 10, and 12 hours—were created to assess each model's ability to predict unplanned overtime at various points across the work shift.
Results Classification accuracy ranged from 57 to 64% across three analysis timeframes. Accuracy was lowest at 10 hours and highest at shift end. Features with the highest importance include minutes spent using a communication device and percent of medications delivered via a syringe.
Conclusion Ambient data streams can serve as information channels that contain signals related to unplanned overtime as a proxy indicator of RN strain as early as 8 hours into a work shift. This study represents an initial step toward enhanced detection of RN strain and proactive prevention of missed or delayed patient care.
Hearing and Neurodevelopmental Outcomes of Young Infants with Parechovirus-A and Enterovirus Meningitis: Cohort Study in Singapore Children and Literature Review
Authors: Lee Elis Yuexian , Tan Jessica Hui Yin , Choong Chew Thye , Tee Nancy Wen Sim , Chong Chia Yin , Thoon Koh Cheng , Maiwald Matthias , Tan Melody Si Shan , Tan Natalie Woon Hui 
Published: September 2020

Abstract
Parechovirus-A (PeV-A) and Enterovirus (EV) commonly cause childhood aseptic meningitis. Bacterial meningitis in children has been associated with devastating long-term sequelae. However, developmental outcomes are unclear in Parechovirus meningitis. This study aims to review the clinical findings and developmental outcomes of infants with PeV-A and EV meningitis. We performed a retrospective study of infants aged 90 days or younger being admitted to our hospital with PeV-A meningitis between November 2015 and July 2017, with positive cerebrospinal fluid (CSF) PeV-A PCR and negative blood and CSF bacterial cultures. Hearing and neurodevelopmental outcomes were compared with a previous cohort of infants aged 90 days or younger with EV meningitis admitted from January 2015 to December 2015. A total of 161 infants were included in our study, of which 68 infants (42.2%) had PeV-A meningitis and 93 infants (57.8%) had EV meningitis. We assessed their developmental outcome at 6 months, 1 year, and 2 years post-meningitis. At 2 years post-meningitis, three infants with PeV-A meningitis had developmental delay (5.5%), whereas none with EV meningitis had developmental delay. One patient had speech delay and autism spectrum disorder, while two had mild speech delay. When compared with our cohort of EV meningitis ≤90 days old, children with PeV-A meningitis ≤90 days old were more likely to have developmental delay 2 years post-meningitis (odds ratio 2.4, 95% confidence interval 2.0–3.0, p = 0.043). None of the patients with PeV-A or EV meningitis had sensorineural hearing loss or neurological sequelae, such as cortical blindness, oropharyngeal dysphagia, hydrocephalus, epilepsy, or cerebral palsy. Infants with PeV-A meningitis had a significant risk of developmental delay 2 years post-meningitis compared with those with EV meningitis. It is important to follow-up the developmental milestones of infants diagnosed with PeV-A meningitis for at least 2 years; and when they develop developmental delay, to ensure that they receive appropriate intervention.
Assessment of an Orthopaedic Templating Software Package for Uncemented Total Hip Arthroplasty
Authors: Newman Michael , Hartwright David 
Published: September 2020

AbstractThe aim of this study was to assess a large, single-surgeon dataset of uncemented total hip arthroplasties that had been templated using software. This assessment compared preoperative templated predictions with what was implanted with regard to (1) femoral prosthesis size and (2) acetabular cup size. The operation notes for two types of uncemented total hip arthroplasty performed by a single surgeon between January 9, 2008, and March 21, 2019, were assessed. The data were refined so that only those that were fully templated on a correctly calibrated pelvic radiograph were included. This provided a total of 153 cases. The predicted software template was compared with actual implanted component sizes. With regard to the femoral stems, the templating software was exactly correct in 45.75% of cases and was accurate to within one size in 87.59% of cases. With regard to the acetabular component, the templating software was exactly correct in 52.94% of cases and was accurate to within one size (2 mm) in 86.94% of cases. Templating software offers an accurate prediction of the size of uncemented femoral and acetabular components. In addition, the benefits of templating include cognitive rehearsal, insight into potentially challenging aspects of surgery, and highlighting intraoperative issues where there is a large intraoperative deviation from what is templated. This study demonstrates the congruence and reproducibility of templating software when compared with other smaller studies performed in the literature.
Expressivism, self-knowledge, and rational agency
Authors: Blackwood Stephen 
Published: September 2020

AbstractOne family of thought about self-knowledge has argued that authoritative self-ascriptions express a form of higher-order knowledge whose special character is explained by the role that knowledge plays in rational agency. In contrast to this “regulative model”, according to Wittgenstein’s treatment of self-knowledge authoritative self-ascription of one’s present-tense mental states is explained by the fact that sincere self-ascriptions express the very states they self-ascribe. The Wittgensteinian account is epistemologically deflationary, and it makes no use of higher-order thought to account for the distinctive features of self-ascriptions. It is argued that the regulative model faces difficulties that both undermine it and reinforce the Wittgensteinian explanation. Making use of ideas from Donald Davidson and Richard Moran, an alternative first-order sketch of rational agency consistent with the expressivist view is offered.
Determinants of happiness among healthcare professionals between 2009 and 2019: a systematic review
Authors: Muthuri Rose Nabi Deborah Karimi , Senkubuge Flavia , Hongoro Charles 
Published: September 2020

AbstractHappiness is characterized by experiencing positive emotions while simultaneously perceiving one’s life as meaningful and worthwhile. Research on the mental health of healthcare professionals usually focuses on psychopathology as opposed to the positive aspects of mental health. Thus, the purpose of this study is to examine recent literature on individual-level and organization-level determinants of healthcare professionals happiness. The EBSCOhost, PubMed, Scopus, and Web of Science databases were searched for articles published between 2009 and 2019 that focused on happiness among healthcare professionals. Based on the eligibility criteria, both quantitative and qualitative studies were selected for this systematic review. The final review included a total of 18 studies. The main measures of healthcare professionals happiness in cross-sectional and intervention studies were self-report measures, and the main measures of happiness in qualitative studies were interviews. Multiple determinants of healthcare professionals happiness were identified in this systematic review. The interplay between individual-level and organization-level determinants collectively contributes to the happiness of healthcare professionals. Existing evidence highlights the importance of healthcare professionals happiness in the strengthening of the healthcare workforce and healthcare systems. This review also highlights the importance of health policy makers, health authorities and healthcare professionals in creating and effectively implementing policies and strategies to increase healthcare professionals happiness. Future similar studies should use large and more heterogeneous samples of healthcare professionals from various settings to generate contextually relevant and robust evidence regarding methods to enhance healthcare professionals happiness and ultimately the performance of health systems globally.
Nanaerobic growth enables direct visualization of dynamic cellular processes in human gut symbionts
Authors: García-Bayona Leonor , Coyne Michael J. , Hantman Noam , Montero-Llopis Paula , Von Salena S. , Ito Takeshi , Malamy Michael H. , Basler Marek , Barquera Blanca , Comstock Laurie E. 
Published: September 2020

Significance
Despite recent technological advances to study the human gut microbiota, we still lack a facile system to image dynamic cellular processes in most abundant gut species due to the requirement of oxygen for chromophore maturation of commonly used fluorescent proteins. Here, we took advantage of the ability of anaerobes of the gut microbiota to respire aerobically and grow robustly at 0.10 to 0.14% oxygen. This physiologic concentration of oxygen is sufficient for fluorescent proteins to mature, allowing for visualization of biological processes never before imaged in these bacteria. This advance will allow for numerous types of analyses in actively growing “nanaerobic” gut bacteria including subcellular protein localizations, single-cell analyses, biofilm imaging, and protein interactions with other microbes and the host.