bluuebunny/crossref_metadata_2025_split huggingface dataset:
1-7PROFILE OF HYPERTENSION IN HEMODIALYSIS PATIENTS IN CIKINI CCI HOSPITAL: A DESCRIPTIVE STUDY
Authors: Taruna Dicky , Claresta Anesty , Panggabean Steven D. , Silalahi Todung D.A. 
Published: July 2020

Background:
Chronic kidney disease (CKD) is one of the most common health problems in Indonesia. Some CKD patients may develop to end-stage renal disease (ESRD), which requires renal replacement therapy such as hemodialysis. Many people with ESRD have hypertension. There was no research about the profile of hypertension in hemodialysis patients in Cikini CCI hospital before.

Objective:
To study hypertension among hemodialysis patients in Cikini CCI hospital.

Method:
This is a cross-sectional descriptive study. The subjects of the study are ESRD adult patients on the regular hemodialysis treatment in Cikini CCI hospital. Data were obtained from 121 patients from July to December 2019. The medical record of each patient was reviewed to identify the hypertension of ESRD. We studied the hypertension profile on hemodialysis patients such as hypertension in gender, age group, how long they take hemodialysis, and frequencies in a week.

Result:
The result showed that 106 patients (87.6%) are hypertension. Most of the patients were male (53.7%). Most of hypertension in the age between 40 to 60 years old (49%). Based on the duration of hemodialysis, the majority of hypertension was found in patients undergoing hemodialysis for less than one year (53.7%). Hypertension is more common in the group that doing hemodialysis three times a week (80.1%) rather than twice a week (19.8%).

Conclusion:
Hypertension is almost found in the majority of patients undergoing hemodialysis in Cikini CCI hospital.
1-8DIAGNOSTIC VALUE OF HEMOGLOBIN LEVELS, UREA REDUCTION RATIO AND Kt/V IN DETECTING INTRADIALYTIC HYPERTENSION IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS AT SANGLAH HOSPITAL DENPASAR
Authors: Setyawan Yuswanto , Raka-Widiana I Gde , Kandarini Yenny 
Published: July 2020

Background:
Intradialytic hypertension is the most common complication in hemodialysis patients, with a prevalence of 38%. It is also one of the causes of death in hemodialysis patients.

Aim:
To determine the diagnostic value of haemoglobin (Hb) levels, Urea Reduction Ratio (URR) and Kt/V in detecting intradialytic hypertension in chronic kidney disease (CKD) patients undergoing hemodialysis

Method:
A cross-sectional study was conducted on 222 CKD patients undergoing hemodialysis at Sanglah Hospital, Denpasar, from 1 January 2018 to 30 June 2019. Intradialytic hypertension is defined as an increase in mean arterial blood pressure (MAP) ≥15 mmHg from baseline at the end of the hemodialysis session.

Results:
The AUC values of Hb levels, URR, and Kt/V were 75.5% (95% CI 60.5% - 90.4%, p 0.05), 92.4% (95% CI 87% – 97,9%, p 0.004), and 90.4% (95% CI 84.5% – 96.4%, p 0.006) respectively, with cut-off values of 6.66 g/dL (sensitivity 97.1%, specificity 80%), 83.17% (sensitivity 80%, specificity 85.7%), and 2.16 (sensitivity 80%, specificity 86.4%).

Conclusion:
Haemoglobin levels, URR and Kt/V, have good sensitivity and specificity in predicting intradialytic hypertension in CKD patients undergoing hemodialysis.
2-1EFFECTIVENESS OF ACEI/ARB MONOTHERAPY ON SURVIVAL OUTCOMES IN PATIENTS WITH HYPERTENSIVE CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF LARGE COHORT STUDIES
Authors: Laurentius Andrea , Ivan Ignatius 
Published: July 2020

Cardiovascular morbidity is a significant promoter of 50% overall mortality in renal hypertensive patients. Based on Joint National Committee 8 Guideline, treatment of hypertensive chronic kidney disease (CKD) using angiotensin receptor blockers (ARB) or angiotensin-converting enzyme inhibitor (ACEi) are suggested as they pharmacodynamically block the action of angiotensin II. To address the problem related to inconsistent therapeutic benefits of renin-angiotensin-aldosterone system (RAAS) blockers, head-to-head systematic review and meta-analysis of cohort studies examining pharmacological benefits of ARB/ACEi monotherapy toward the prognosis of major cardiovascular event (MACE) and all-deaths in hypertensive CKD patients were conducted. Database access was obtained through login into remote library, and terms of medical references refined advanced keywords searching. Seven out of 714 studies were systematically assessed from total of five databases using Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) tool deliver quality of studies. Several studies had shown therapeutic benefits of ACEi/ARB in improving cardiovascular prognosis of hypertensive CKD patients. Based on quantitative analysis of a five-year follow-up, we found 31% higher survival rate for patients who received ACE-I/ARB monotherapy compared to non-users via random effect estimation.
Furthermore, seven studies suggested similar outcomes favoring ACEi/ARB for long-term survival benefit against all-cause mortality. This could be biologically explained through the mechanism of RAAS blockers in preventing cardiac remodeling. Thus, further studies toward ACEi/ARB monotherapy in preventing MACE and deaths of hypertensive CKD patients are recommended to support the conclusion.
2-5THE DETERMINANT OF CENTRAL BLOOD PRESSURE IN TYPE 2 DIABETES PATIENTS
Authors: Khumaedi Anandhara Indriani , Nugroho Pringgodigdo , Purnamasari Dyah 
Published: July 2020

Introduction:
Blood pressure (BP) control has been long known to have a role in reducing mortality and morbidity in type 2 diabetes (T2DM) patients. However, routine office BP measurement using brachial BP failed to represent true aortic BP reflected in target organs such as heart, kidney, and brain due to pulse pressure amplification and pulse wave reflection throughout the arterial tree. Several studies suggested that central BP might be a better predictor for cardiovascular (CV) risk than brachial BP in various populations. This study aimed to see the relationship between central systolic blood pressure (cSBP) with various demographic and diabetes-related parameters.

Methods:
This is a cross-sectional study involving 95 T2DM patients. Office blood pressure was measured using Omron® automatic sphygmomanometer. Meanwhile, central blood pressure was measured using SphygmoCor® XCEL. Diabetes-related parameters measured in this study are duration, A1C, and albumin-to-creatinine ratio (ACR). The analysis was conducted in all subjects, and in subgroup based on hypertensive status.

Result:
Among 95 T2DM patients were recruited; 70,5% of them are female. The mean age in this study was 48 years old (CI: 47,3 – 50,5); and mean BMI was 26 kg/m2 (CI: 25,6 – 27,3). Fifty-point-five percent of patients in this study were hypertensive. Central SBP were obviously, higher in patients with hypertension compared to non-hypertension (122,7 mmHg [CI: 93 – 191] vs 136,1 mmHg [CI: 131,4 – 140,8] respectively) and BP amplification (bSBP – cSBP) was more profound in hypertensive group (18,1 mmHg [CI:16,9 – 19,2]) compared to non-hypertensive group (14,5 mmHg [CI: 13,0 – 15,2]) respectively. Overall, a strong correlation found between bSBP and cSBP (R2 = 0,975). Multivariate analysis showed bSBP remained the only factor positively associated with cSBP. In subgroup analysis, bSBP showed strong correlation to cSBP both in hypertensive group and in non-hypertensive group (R2 = 0,987 and R2 = 0,977, respectively). In multivariate analysis, bSBP remained the only predictor of cSBP in hypertensive group, whereas in non-hypertensive group bSBP and female were predictors of cSBP. None of the diabetes-related parameters (duration, HbA1C, and ACR) are correlated with cSBP.

Result:
Agreement between cSBP and bSBP is very strong both in all subjects and in subgroup analysis. This might suggest that although cSBP proven superior than bSBP regarding CV risk predictor and target organ damage, high concordance correlation might suggest that these are still interchangeable, especially when central BP measurement is not convenient.
3-1INTRACRANIAL ARTERY STENOSIS PATTERN IN ISCHEMIC STROKE PATIENTS THROUGH TRANSCRANIAL DOPPLER(TCD) IN DR. M. DJAMIL HOSPITAL, PADANG
Authors: Sutia Dedi , Indra Syarif , Busra Meldayeni , K Yoga setia 
Published: July 2020

Background:
Intracranial artery stenosis is one of significant risk factors in the occurrence of vascular disorders. Intracranial artery stenosis occurs in 33% −50% in stroke patients and 50% in transient ischemic attack patients. Transcranial doppler sonography (TCD) is one of the modalities that can detect intracranial stenosis with 79% sensitivity and 94% specificity. Transcranial doppler sonography can detect stenosis or occlusion of middle cerebral artery (MCA), bifurcatio of Internal Carotid Artery (ICA), anterior cerebral artery (ACA), vertebral arteries (VA), basilar artery (BA), and Posterior Cerebral artery (PCA). According to RSUP DR. M. Djamil medical record data that was obtained in 2018, 35.2% patients experienced intracranial arterial blood vessel disorders based on the results of TCD examination. This study aims to determine the characteristics of intracranial artery stenosis patterns in ischemic stroke patients through TCD examination in RSUP. Dr. M. Djamil Padang.

Method:
This study was an adescriptive study. The population was ischemic stroke patients in the Neurology Outpatient Clinic of DR. M. Djamil Hospital, Padang, who underwent TCD examination from January 1st to December 30th, 2019, with an evaluation of mean flow velocity (MFV).

Results:
In this study, there were 192 subjects; 57.29% of subjects were male. The most dominant age range was 51–60 years (30.21%). There were 55.73% of subjects with normal TCD results, 35.42% with intracranial artery stenosis, and 8.85% with general atherosclerosis. Based on the location, intracranial arteries stenosis was found most often in the Left Middle Cerebral Artery (26.47%), followed by Right Middle Cerebral Artery and Right Vertebral Artery (8.82%).

Conclusion:
Middle Cerebral Artery (MCA) is the most common location of intracranial arteries stenosis that was found in ischemic stroke patients and predominantly occurred in the left cerebral hemisphere.
3-4FUROSEMIDE USE AS POSTPARTUM MANAGEMENT IN WOMEN WITH HYPERTENSIVE DISORDER OF PREGNANCY: A SYSTEMATIC REVIEW
Authors: Ampri Irfan A. H. , Adham Rara M. , Leonardo  , Ivan Ignatius 
Published: July 2020

Introduction:
Hypertensive disorders of pregnancy affect 10 % of pregnancy worldwide. It is also complicated maternal mortality and morbidity. Hypertensive disorders may persist after delivery in the puerperal period up to 12 weeks postpartum. The physiologic changes in pregnancy revert to normal in the postpartum period. Including the return of fluid from interstitial and extravascular compartments into intravascular. The use of diuretics is more fitting in the postpartum period and as an additional anti-hypertensive agent.

Methods:
We formulated a specific search strategy and used the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). PubMed, Cochrane, Scopus, Science Direct, and Ebscohost are used as the literature Database. The criteria of the included studies are as follows: human study, randomized controlled trial; relevant patient characteristic; outcome assessment. Two independent authors assessed the quality of the study. This systematic review used the Cochrane Risk of Bias Tool 2.0.

Results:
Database searching provides a total of 58 studies. A total of 29 studies are duplicates. Six studies are included in the qualitative synthesis. One study does not show the results of the trial. A total of five studies are used. All studies are randomized controlled trials. One study reveals that there was a significant difference in systolic blood pressure, diastolic blood pressure, and mean arterial pressure between the treatment group and the control group. Another study reveals that the use of furosemide reduces the use of another antihypertensive therapy on the hospital and when discharged. Three studies show the insignificant result in reducing anti-hypertensive agents and blood pressure.

Conclusion:
Furosemide use as an anti-hypertensive agent on the postpartum setting is still unclear. Furosemide therapy may be useful in reducing the risk of complications in a patient with severe preeclampsia on postpartum settings such as eclampsia and pulmonary edema. Furosemide may reduce the amounts of anti-hypertensive agents used. Length of stay is the hospital may not be affected by the use of furosemide. The additional high-quality study should be conducted to elucidate furosemide use as a puerperal anti-hypertensive agent.
3-6EFFECTIVENESS OF DEMONSTRATION COUNSELING METHOD ON KNOWLEDGE LEVEL REGARDING COMPLIANCE WITH DIET ON HYPERTENSION PATIENTS IN PUSKESMAS SUNGAI KAKAP, KUBU RAYA REGENCY, WEST KALIMANTAN
Authors: Islami Aditya , Nasution Bakrie Bayquni , Mustika Angnes Dera , Sonia Gatria , Purba Nur Harini 
Published: July 2020

Background:
Hypertension is still a high cause of death and illness. The results of the 2018 Riskesdas study showed that there was an increase in the number of hypertension that remained permanently from 2013 to 2018. Hypertension was still ranked first in the highest number of non-communicable diseases in Sungai Kakap. The most common conventional education patterns used in Primary Health Care Facilities in the form of lecture methods are still seen to be ineffective in influencing the level of public knowledge of salt needs and other nutritional content as well as eating patterns suitable for hypertensive patients.

Methods:
This research is a quasi-experimental research design of One Group Pretest Posttest, the results of which will be analyzed descriptively and analytically. Samples were taken by purposive sampling totaling 32 people divided into two groups: the test group was given conventional counseling material lecture method and the test group was given counseling material with a demonstration method. Primary data were obtained from pretest and posttest using a questionnaire in hypertensive patients in the working area of Puskesmas Sungai Kakap. Data were analyzed using the unpaired T-test.

Result:
The mean post-test in the conventional lecture method group was 69.37 ± 16.11, and there were no significant differences in the comparison between pre-test and post-test scores. The mean post-test results in the group with the demonstration method treatment were worth 85.00 ± 14.60, and there was a significant difference in the comparison between the pre-test and post-test scores in the group with the counseling treatment demonstration method where the post-test value was higher than the post-test. The mean post-test score of the group using the demonstration method was of higher significance statistically when compared to the group with the lecture method (Sig <0.05, 95% confidence level) with a value difference of 15.62.

Summary:
Hypertension Diet Counseling with Demonstration Method is more effective compared to Conventional Counseling Lecture Method.
3-8IMPACT OF CHRONIC HYPERTENSION ON IN-HOSPITAL MORTALITY IN PATIENTS WITH ACUTE CORONARY SYNDROME
Authors: Padmaridho Fachri , Muzakkar Akhtar Fajar 
Published: July 2020

Background:
Chronic hypertension is one of the cardiovascular risk factors in the development of atherosclerosis, the process responsible for causing Acute Coronary Syndrome (ACS). Chronic hypertension needs attention not only as a risk factor for the incidence of ACS but also as a factor that can worsen output of ACS, so that deserves to get a tailored approach in management and follow up.

Objective:
To determine the relation between Chronic Hypertension with In-hospital mortality in patients with Acute Coronary Syndrome (ACS)

Method:
This study is a cross-sectional study conducted at Makassar Cardiac Center at Wahidin Sudirohusodo Hospital. The subjects of this study were patients with Acute Coronary Syndrome (ACS) from June 2018 to May 2019 with a total sampling method of 707 patients obtained from ACS Registry Indonesia. Data were analyzed using the Chi-Square method.

Results:
Patients with chronic hypertension had a significantly higher mortality rate (74.1%) compared to patients without chronic hypertension (p = 0.028). ACS patients with chronic hypertension had an increased risk of In-hospital mortality compared to those without, the odds ratio of 2.00 (p = 0.03)

Conclusion:
ACS patients with chronic hypertension are twice as likely to die at the hospital, so thus requiring a tailored approach in management and follow up for better outcomes.
4-2TAXANES-INDUCED CARDIOTOXICITY: A CASE REPORT IN BREAST CANCER PATIENT WITH PRE-EXISTING HYPERTENSION
Authors: Hartopo A.B. , Anggraeni V.Y. , Mumpuni H. , Jhundy B.W. , Hutajulu S.H. 
Published: July 2020

Background:
Hypertension is one of the most common comorbidities reported in patients with malignancy. This population had a higher risk of developing cardiotoxicity. Taxanes is an important therapeutic agent for several malignancies, including breast cancers. Their applicability, however, is limited by cardiotoxicity. The optimal strategy to prevent and manage chemotherapy-related cardiotoxicity (CTRCT) has not yet implemented in clinical practices.

Case:
A 63 years old breast cancer female patient was planned to be treated with Taxanes for six cycles. On admission, there were no cardiovascular symptoms. The patient had a history of hypertension and no history of myocardial infarction or congestive heart failure (CHF). Baseline transthoracic echocardiogram demonstrated normal left ventricular ejection fraction (LVEF) 66%. She received calcium channel blocker for her hypertension during chemotherapy. After the second cycle, the patient experienced palpitation, and there were no other cardiovascular symptoms. Electrocardiogram showed Left Bundle Branch Block. Echocardiogram revealed LVEF 46% with anteroseptal and inferoseptal hypokinetic. She was suspected as CHF chemotherapy-induced. Taxane was stopped, and she was treated with angiotensin receptor blocker, beta-blocker, and loop diuretic. Two months after therapy, her LVEF revealed partial recovery with LVEF 60% and no reported symptoms.

Conclusion:
Prophylactic agents targeting pre-existing cardiac risk factor has not been implemented in clinical practice but may soon change. Early detection and prompt management appear crucial to reverse left ventricular dysfunction in cancer patients receiving taxanes, especially in patients with pre-existing hypertension.
4-3RENAL DENERVATION FOR RESISTANT HYPERTENSION POST-SIMPLICITY-3 HTN TRIAL: META-ANALYSIS AND SYSTEMATIC REVIEW
Authors: Santoso Jimmy O. , Panjaitan Harrison P.B. 
Published: July 2020

Background:
Following the result from SIMPLICITY-3 trial that failed to show the benefit of renal denervation over sham control, the interest on renal denervation had fallen into hibernation. However, there were some authors indicated that SIMPLICITY-3 trial result seemed to have major problems regarding incomplete denervation that led experts to researched and carefully designed studies regarding renal denervation. Since then, there was three carefully-designed, sham-controlled studies published about the issue. However, there was no published meta-analysis on randomized trials after SIMPLICITY-3 era. We aimed to conduct a meta-analysis of RCTs to determine the effect of renal denervation in resistant hypertension.

Methods:
A search on MEDLINE and EMBASE was conducted in January 2020. Randomized clinical studies comparing renal denervation and sham-controlled trial published after SIMPLICITY-3 trial were included for this meta-analysis.

Study selection:
only fully published RCT and abstracts of RCT comparing renal denervation and sham control for resistant hypertension published after SIMPLICITY-3 trial was included. Studies which were duplicated and non-randomized were excluded.

Results:
The analysis included 149 patients from 3 trials with a duration of follow up of 2–6 months. The reduction in 24-h ambulatory SBP was significantly greater in the renal denervation group compared to the sham procedure (WMD −4.74 mmHg, 95% CI −6.5, −2.99; p < 0,001). There was also significant reduction in 24-h DBP (WMD −3.11 mmHg, 95% CI −3.98, −2.23; p < 0,001), office SBP (WMD −7.1 mmHg, 95% CI −9.12, −5.08; p < 0,001), and office DBP (WMD −4,63 mmHg, 95% CI −5.98, −3.28; p < 0,001).

Conclusion:
Following SIMPLICITY-3 trial, there were positive results regarding renal denervation on resistant hypertension. Renal denervation significantly reduced blood pressure compared to sham control. Our meta-analysis underscores the importance of conducting new well-designed studies to confirm our observed results.
4-5THE RISK OF HYPERTENSION IN ADULTS EXPOSED TO SECONDHAND SMOKE: A META-ANALYSIS
Authors: William Andy , Ningrum Indra Utami Mutiara , Panjaitan Harrison Bernard 
Published: July 2020

Background:
Overwhelming evidence supports the conclusion that cigarette smoking is associated with various adverse cardiovascular events, including hypertension. In addition, exposure to secondhand smoke (SHS) can be just as dangerous because of the lack of filters. However, the effect of secondhand smoke exposure in increasing the risk of hypertension is still unclear.

Objective:
To investigate the risk of hypertension from secondhand smoke exposure among adults who never smoked.

Method:
Systematic search was conducted using MEDLINE and Science Direct for studies up to January 2020, which reported the risk of hypertension in adults exposed to secondhand smoke compared to those who did not. The risk of bias was assessed using the Newcastle-Ottawa Scale.

Results:
A total of 8 studies were included in the main analysis. The total number of subjects across all studies was 5,059,347 subjects. The pooled unadjusted results showed that exposure to SHS was not associated with the risk of hypertension (pooled OR = 1.21; 95% CI: 0.91 – 0.61). However, the pooled adjusted OR did show an increased risk of hypertension among subjects exposed to SHS (pooled aOR = 1.25; 95% CI 1.12–1.40). Subgroup analysis showed a more definite risk in the female population (pooled aOR = 1.28; 95% CI 1.13–1.45).

Conclusion:
When adjustment for potential confounders was made, exposure to SHS was associated with a higher risk of developing hypertension. Therefore, exposure to SHS has a significant public health implication for the prevention of hypertension.
Posteromedial Approach to Tibial Plateau Fracture Nonunion
Authors: Shields Charlotte N. , Eftekhary Nima , Egol Kenneth A. 
Published: July 2020

Summary:
Tibial plateau fractures can involve planes that require reduction and stabilization from a posterior approach. This includes posteromedial, posterolateral, and posterior column shear type injuries. This video outlines the prone posteromedial approach to the tibial plateau for posterior column fracture exposure, reduction, and fixation.
Operative Fixation of a Displaced Midshaft Clavicle Fracture
Authors: Campbell David H. , McKee Michael D. 
Published: July 2020

Summary:
Midshaft clavicle fractures are frequently encountered orthopaedic injuries. Significant displacement portends a higher likelihood of nonunion and symptomatic malunion after nonoperative treatment. Surgical fixation has been shown to reduce the rate of these adverse outcomes. However, the benefit of surgery is narrowly defined and the decision to offer operative treatment involves a careful analysis of patient clinical factors, expectations, and concomitant injuries. In North America, fixation is most commonly performed with a precontoured plate and screw construct. Frequently, fracture patterns are amenable to direct reduction and primary bone healing, but the plate may also be used as a bridging construct for comminuted fractures. This video demonstrates the superior approach to clavicular plating. We detail the exposure, reduction, and fixation using lag screws and stabilization with a plate and screw construct.