bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Body Mass Index and Serum Markers of Tissue Damage with Postoperative Pain. The Role of Lactate Dehydrogenase for Postoperative Pain Prediction
Authors: González-Callejas Cristina , Aparicio Virginia A , De Teresa Carlos , Nestares Teresa 
Published: November 2019

Abstract

Objectives
i) To analyze the association of body mass index (BMI) and some serum tissue damage markers with postoperative pain. ii) To establish a biochemical marker cutoff point able to predict moderate to severe postoperative pain.

Design
Cross-sectional study.

Subjects
Ninety-six adult male patients from Southern Spain (55 ± 13 years old) who underwent an inguinal hernioplasty.

Methods
Postoperative pain (eight hours after surgery) was assessed through a visual analog scale (VAS). Moderate to severe pain was defined as a VAS &gt; 50 mm. BMI was calculated and medication, alcohol consumption, and smoking habit registered. Eight hours after surgery, some serum markers such as fibrinogen, lactate dehydrogenase (LDH), C-reactive protein, cortisol, creatine kinase, glutamic-pyruvic, glutamic oxaloacetic, and gamma-glutamyltransferase transaminases were determined by standard procedures.

Results
After adjusting for potential confounders, BMI was not associated with postoperative pain (P &gt; 0.05). Serum fibrinogen was associated with greater postoperative pain (β = 0.333, P &lt; 0.05). Serum LDH concentration was strongly associated with greater postoperative pain (β = 0.606, P &lt; 0.001). Alcohol consumption was associated with higher postoperative pain (β = 0.212, P &lt; 0.05). No associations were observed regarding age, tobacco consumption, and the rest of serum markers studied. Serum LDH concentration was able to discriminate between presence/absence of moderate to severe postoperative pain (receiver operating characteristic area under the curve = 0.655, P ≤ 0.01). An LDH concentration &gt;204 IU/L was associated with a three-times increased odds ratio of moderate to severe postoperative pain.

Conclusions
Contrary to expectations, greater BMI was not associated with higher postoperative pain. Notwithstanding, the assessment of serum LDH might provide useful information to predict moderate to severe postoperative pain.
Detection rate is not higher for women with BBD history in breast cancer screening
Authors: Qu Penghuan , Liu Xueou , Huang Yubei , Feng Ziwei , Wang Xin , Dai Hongji , Zhang Liwen , Song Fangfang , Li Haixin , Zheng Hong , Song Fengju , Chen Kexin 
Published: November 2019

ABSTRACT

Background
To investigate whether women with benign breast disease (BBD) history have higher breast cancer detection rate in screening.

Methods
We reviewed data for 33 001 female participants in Multi-modality Independent Screening Trial (MIST). Corresponding data for 6823 breast cancer patients were retrieved from the Tianjin Breast Cancer Cases Cohort (TBCCC) and analyzed for comparison.

Results
The breast cancer detection rate was 2.83‰ among women with BBD history and 3.28‰ in women without. Moreover, the proportion of carcinoma in situ (CIS) was also lower in women with BBD history than women without (7.69 versus 20.31%). In contrast, analysis of TBCCC data revealed a higher proportion of CIS in patients with BBD history (5.05%) than patients without (3.26%). Our data showed that a larger proportion of women with BBD history had undergone previous breast examinations. Additionally, among participants diagnosed with both breast cancer and BBD in MIST, we found a lower proportion of CIS in women with BBD history (11.76%) compared to women without (32.14%).

Conclusions
Women with BBD history were not found to have higher detection rate in breast cancer screening. Women with BBD history were more likely to be proactive in seeking breast examinations and to have breast cancer be diagnosed in clinic.
Institutional Trading around Corporate News: Evidence from Textual Analysis
Authors: Huang Alan Guoming , Tan Hongping , Wermers Russ 
Published: November 2019

Abstract
We examine institutional trading surrounding corporate news by combining a comprehensive database of newswire releases on U.S. firms with a high-frequency database of institutional trades. To identify the ability of institutions to predict or quickly interpret news, we form “news clusters” of related news about a particular firm that occurs in rapid succession. We find that institutions chiefly trade on the tone of news directly after the earliest news release in a cluster, and such news-motivated trading predicts returns over the following weeks. Our results suggest that institutional investors contribute to price efficiency through the speedy interpretation of public information.
Refugee Protection Standards in Transition: Studying German NGOs and Public Administrations
Authors: Zimmermann Inga , Rosenow-Williams Kerstin , Behmer-Prinz Katharina , Bergedieck Alina 
Published: November 2019

Abstract
From 2014 to 2015, the number of asylum applications increased by 155 per cent in Germany, which has severely altered Germany’s refugee response system. This article analyses resulting local-level changes in the protection standards for refugees. It sheds light on the interplay between municipal and organisational actors in implementing protections concepts and measures for refugee accommodations. The study applies a neo-institutional research framework to explain organisational behaviour at the level of non-governmental organisations and public administration asking how the security needs of refugee women are met at the “street-level bureaucracy”. Through empirical fieldwork, it shows that in 2018, gender-specific protection standards were higher than before 2014 due to mechanisms of regulative, normative and mimetic isomorphism. The joint development of Minimum Standards for the Protection of Refugees and Migrants in Refugee Accommodation Centres in 2016 by the United Nations Children's Fund, the Federal Ministry for Family Affairs, Senior Citizens, Women and Youth and numerous non-governmental organisations has supported this process. The research combines current debates in refugee studies with theoretical concepts from organisational sociology, gender studies and policy research.
Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature
Authors: Guisle Isabelle , Gratuze Maud , Petry Séréna , Morin Françoise , Keraudren Rémi , Whittington Robert A , Hébert Sébastien S , Mongrain Valérie , Planel Emmanuel 
Published: November 2019

AbstractStudy ObjectivesAggregates of hyperphosphorylated tau protein are a hallmark of Alzheimer’s disease (AD) and other tauopathies. Sleep disturbances are common in AD patients, and insufficient sleep may be a risk factor for AD. Recent evidence suggests that tau phosphorylation is dysregulated by sleep disturbances in mice. However, the physiological regulation of tau phosphorylation during the sleep–wake cycle is currently unknown. We thus aimed to determine whether tau phosphorylation is regulated by circadian rhythms, inherently linked to the sleep–wake cycle.MethodsTo answer these questions, we analyzed by Western blotting tau protein and associated kinases and phosphatases in the brains of awake, sleeping, and sleep-deprived B6 mice. We also recorded their temperature.ResultsWe found that tau phosphorylation undergoes sleep-driven circadian variations as it is hyperphosphorylated during sleep but not during acute sleep deprivation. Moreover, we demonstrate that the mechanism behind these changes involves temperature, as tau phosphorylation was inversely correlated with circadian- and sleep deprivation-induced variations in body temperature, and prevented by housing the animals at a warmer temperature. Notably, similar changes in tau phosphorylation were reproduced in neuronal cells exposed to temperatures recorded during the sleep–wake cycle. Our results also suggest that inhibition of protein phosphatase 2A (PP2A) may explain the hyperphosphorylation of tau during sleep-induced hypothermia.ConclusionTaken together, our results demonstrate that tau phosphorylation follows a circadian rhythm driven mostly by body temperature and sleep, and provide the physiological basis for further understanding how sleep deregulation can affect tau and ultimately AD pathology.
Effects of Cognitive Load on Pure-Tone Audiometry Thresholds in Younger and Older Adults
Authors: Heinrich Antje , Ferguson Melanie A. , Mattys Sven L. 
Published: November 2019

Objectives:
Cognitive load (CL) impairs listeners’ ability to comprehend sentences, recognize words, and identify speech sounds. Recent findings suggest that this effect originates in a disruption of low-level perception of acoustic details. Here, we attempted to quantify such a disruption by measuring the effect of CL (a two-back task) on pure-tone audiometry (PTA) thresholds. We also asked whether the effect of CL on PTA was greater in older adults, on account of their reduced ability to divide cognitive resources between simultaneous tasks. To specify the mechanisms and representations underlying the interface between auditory and cognitive processes, we contrasted CL requiring visual encoding with CL requiring auditory encoding. Finally, the link between the cost of performing PTA under CL, working memory, and speech-in-noise (SiN) perception was investigated and compared between younger and older participants.

Design:
Younger and older adults (44 in each group) did a PTA test at 0.5, 1, 2, and 4 kHz pure tones under CL and no CL. CL consisted of a visual two-back task running throughout the PTA test. The two-back task involved either visual encoding of the stimuli (meaningless images) or subvocal auditory encoding (a rhyme task on written nonwords). Participants also underwent a battery of SiN tests and a working memory test (letter number sequencing).

Results:
Younger adults showed elevated PTA thresholds under CL, but only when CL involved subvocal auditory encoding. CL had no effect when it involved purely visual encoding. In contrast, older adults showed elevated thresholds under both types of CL. When present, the PTA CL cost was broadly comparable in younger and older adults (approximately 2 dB HL). The magnitude of PTA CL cost did not correlate significantly with SiN perception or working memory in either age group. In contrast, PTA alone showed strong links to both SiN and letter number sequencing in older adults.

Conclusions:
The results show that CL can exert its effect at the level of hearing sensitivity. However, in younger adults, this effect is only found when CL involves auditory mental representations. When CL involves visual representations, it has virtually no impact on hearing thresholds. In older adults, interference is found in both conditions. The results suggest that hearing progresses from engaging primarily modality-specific cognition in early adulthood to engaging cognition in a more undifferentiated way in older age. Moreover, hearing thresholds measured under CL did not predict SiN perception more accurately than standard PTA thresholds.
Combination of 1,064-nm Neodymium-doped Yttrium Aluminum Garnet Laser and Steroid Tape Decreases the Total Treatment Time of Hypertrophic Scars: An Analysis of 40 Cases of Cesarean-Section Scars
Authors: Tsai Chia-Hsuan , Kao Huang-Kai , Akaishi Satoshi , An-Jou Lin Jennifer , Ogawa Rei 
Published: November 2019

BACKGROUND
The 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (Cutera, Inc., Brisbane, CA) and steroid tape (fludroxycortide tape) have been used to treat keloids and hypertrophic scars.

OBJECTIVE
To evaluate the efficacy of contact-mode 1,064-nm Nd:YAG laser therapy and steroid tape for hypertrophic cesarean-section scars versus conservative therapy (steroid tape only).

MATERIALS AND METHODS
A medical record review identified 40 consecutive Japanese patients who had hypertrophic scars (total Japan Scar Workshop Scar Scale [JSS] 2015 evaluation scores of 9 to 12) for more than 1 year after a vertical cesarean section and who were treated at our scar-specialist clinic from July 2015 to December 2017. All 40 patients continued treatment until the total JSS score dropped below 3. Recurrence was defined as a ≥1-point increase in the total JSW score 6 months after achieving a total JSS score <3.

RESULTS
The patients had a mean age of 34.2 years. The test (n = 25) and control (n = 15) groups took on average 16.9 and 24.3 months to achieve a total JSS score <3, respectively (p < .01). In the following 6 months, none of the scars recurred.

CONCLUSION
Nd:YAG laser treatment effectively decreased the total treatment time of hypertrophic cesarean-section scars. An algorithm for treating mild and severe hypertrophic cesarean-section scars is proposed.
Prognostic Factors, Treatment, and Survival in Primary Cutaneous Mucinous Carcinoma: A SEER Database Analysis
Authors: Rismiller Kyle P. , Crowe David R. , Knackstedt Thomas J. 
Published: November 2019

BACKGROUND
Limited information exists on the demographics, tumor characteristics, and treatment in primary cutaneous mucinous carcinoma (PCMC).

OBJECTIVE
The authors sought to describe prognostic factors, incidence rates, and the subsequent primary malignancy (SPM) risk in patients with PCMC.

METHODS
Primary cutaneous mucinous carcinoma cases in the National Cancer Institute's Surveillance, Epidemiology, and End Results data (1972–2013) were analyzed to provide demographic, cancer-related, and treatment information and to calculate incidence and mortality. Patients were stratified by stage (local, regional, distant disease) for comparison. The risk of developing an SPM was calculated.

RESULTS
Four hundred eleven PCMC cases were identified. The age-adjusted incidence was 0.04 cases per 100,000-person years. Blacks were disproportionately affected by PCMC (0.048; 95% confidence interval, 0.034–0.065; p < .001). Approximately 67.4% of patients had local disease, 10.5% had regional disease, and 5.8% had distant disease. Primary cutaneous mucinous carcinoma–specific mortality was independent of sex, age, race, primary site, histologic tumor grade, tumor size, tumor stage, or treatment. The overall frequency of developing a second primary malignancy was not increased in patients with PCMC.

CONCLUSION
Although PCMC occurs with equally in both sexes, it may be more common in African Americans than previously recognized. Although eyelid PCMC may have a higher rate of distant metastasis, all patients need close follow-up.
Laparoscopic hepatic left lateral lobectomy using a combination of the harmonic scapel and the Aquamantys bipolar sealer: a case report
Authors: Gong Yuanfeng , Liao Yadi , Tang Yunqiang 
Published: November 2019

Introduction:
There are so many tools and energy devices, used in liver parenchymal transection and hemostasis. No consensus statement is achieved on what kind of tools or energy devices are more efficient or reliable.

Patient Concerns:
A 40-year-old man presenting with epigastric discomfort was detected with a 6-cm sized mass at segment II/III with enhancement in the arterial phase with washout in the portal site or a delayed phase.

Diagnosis:
The clinical diagnosis was hepatocellular carcinoma.

Interventions:
We herein used a promising new tool, the Aquamantys bipolar sealer, combined with harmonic scalpel in liver parenchymal transection and hemostasis, and take laparoscopic left lateral lobectomy, for example.

Outcomes:
When we used the Aquamantys bipolar sealer to coagulate and push parenchymal apart gently, the vessels were exposed spontaneously.

Conclusion:
The coagulative and hemostatic effect was quite better than the previous tools. It is simple and practicable, and will help us to shorten the learning curve of laparoscopic hepatectomy.
The impact of public hospitals’ privatization on nurse staffing
Authors: Ramamonjiarivelo Zo , Hearld Larry , Weech-Maldonado Robert 
Published: November 2019

Background
Privatization is one of the strategies that public hospitals may adopt to remain competitive. Privatized hospitals may implement nurse staffing cuts as a cost-saving mechanism and to increase financial performance. A better understanding of how privatization may affect nurse staffing is important given its association with patient and organizational outcomes.

Purpose
The aim of this study was to examine the impact of not-for-profit (NFP) and for-profit (FP) privatizations of public hospitals on nurse staffing.

Methodology/Approach
Based on secondary data sets from the American Hospital Association Annual Survey, the Centers for Medicare & Medicaid Services Impact Files, and the Area Health Resources File, this study used a nonexperimental longitudinal design consisting of negative binomial and linear regression models with hospital level and year fixed effects. Our sample consisted of nonfederal and noncritical access, acute care, public hospitals (n = 492) followed from 1997 to 2013 (8,335 hospital-year observations). Nurse staffing was measured as full-time equivalents (FTEs) and skill mix. Privatization was defined as conversion from public to either private NFP or private FP status.

Results
FP privatization was associated with greater decreases in registered nurse (RN) staffing FTEs (incidence rate ratio [IRR] = 0.93, p = .004) and total nurse staffing FTEs (IRR = 0.93, p = .001), compared with NFP privatization: RN staffing FTEs (IRR = 0.95, p = .003) and total nurse staffing FTEs (IRR = 0.96, p = .007).

Conclusion
Overall, privatization was associated with decreased RN FTEs and total nurse staffing FTEs and no changes in licensed practical nurse FTEs and RN skill mix.

Practice Implications
A close monitoring of nurse staffing level, after privatization, is encouraged to prevent potential deterioration in quality of care.
Hospital staffing patterns and safety culture perceptions: The mediating role of perceived teamwork and perceived handoffs
Authors: Upadhyay Soumya , Weech-Maldonado Robert , Lemak Christy H. , Stephenson Amber L. , Smith Dean G. 
Published: November 2019

Background
As hospitals are under increasing pressure to improve quality and safety, safety culture has become a focal issue for high-risk organizations, including hospitals. Prior research has examined how structural characteristics directly impact safety culture. However, and based on Donabedian’s structure–process–outcome quality model, there is a need to understand the processes that intermediate the relationship between structural characteristics and safety culture perceptions.

Purpose
The processes by which registered nurse (RN) and hospitalist staffing may affect safety culture perceptions were examined in this study. Specifically, this study investigates the processes of perceived teamwork across units and perceived handoffs.

Methodology
Data sources for this research included Hospital Survey on Patient Safety Culture from the Agency for Healthcare Research and Quality, the American Hospital Association’s Annual Survey Data, the American Hospital Association Information Technology supplement, and the Area Health Resource File. Two separate mediation models for each process were used. Propensity weights were assigned to each hospital in the sample (N = 207) to adjust for potential nonresponse bias of hospitals that did not assess employee’s safety culture perceptions.

Results
Results suggest that RN staffing influences safety culture perceptions, but hospitalist staffing does not. In addition, RN staffing has an indirect effect on safety culture perceptions through better processes.

Practice Implications
Our study sheds light on how staffing affects safety culture perceptions. Specifically, our findings suggest that positive perceptions of teamwork across units and handoffs are integral in the relationship between RN staffing and safety culture perceptions. Hospital managers should, therefore, invest resources in staff recruitment and retention. In addition, a targeted focus on perceived teamwork and handoffs may allow hospital managers to improve safety culture perceptions.
Analysis of postpartum reversible cerebral vasoconstriction syndrome in China
Authors: Liu Lin , Tan Qi , Huang Ruxun , Hu Zongji 
Published: November 2019

AbstractReversible cerebral vasoconstriction syndrome (RCVS) is a rare clinical syndrome accompanying with severe headache as its main symptom. Postpartum reversible cerebral vasoconstriction syndrome (PPRCVS) refers to RCVS occurring in the puerperium, in which it has a low incidence, and that is easily missed diagnosed and misdiagnosed in clinical practice.By searching in CNKI and Wanfang databases, 9 published articles reported PPRCVS were found, totally including 12 cases with PPRCVS. The clinical data of these 12 cases were accordingly analyzed and summarized. The characteristics of these cases were compared with those reported in other countries, and eventually the clinical characteristics of Chinese PPRCVS patients were summarized.The clinical characteristics of Chinese PPRCVS patients were basically as same as those found in other countries, while the onset age was earlier, PPRCVS often occurred earlier after delivery, with higher proportions of concomitant symptoms and abnormal laboratory and imaging examinations; moreover, and fewer patients were diagnosed by digital subtraction angiography (DSA).
Prediction of relapse and prognosis by expression levels of long noncoding RNA PEG10 in glioma patients
Authors: Xiao Hui , Ding Ning , Liao Hang , Yao Zhigang , Cheng Xiankui , Zhang Jian , Zhao Miaoqing 
Published: November 2019

Abstract

Background:
Long noncoding RNA paternally expressed 10 (lncRNA PEG10) is highly expressed in a variety of human cancers and related to the clinical prognosis of patients. However, to date there has been no previous study evaluating the prognostic significance of lncRNA PEG10 in gliomas. In the present study, we investigated the expression levels of lncRNA PEG10 to determine the prognostic value of this oncogene in human gliomas.

Methods:
Expression levels of lncRNA PEG10 were detected by real-time polymerase chain reaction in a hospital-based study cohort of 147 glioma patients and 23 cases of patients with craniocerebral trauma tissues. Associations of lncRNA PEG10 expression with clinicopathological variables and clinical outcome of glioma patients were investigated.

Results:
The results indicated that expression levels of lncRNA PEG10 were significantly increased in human gliomas compared to normal control brain tissues. In addition, lncRNA PEG10 expression was progressively increased from pathologic grade I to IV (P = .009) and correlated with the Karnofsky performance status (P = .018) in glioma patients. Furthermore, we also found that glioma patients with increased expression of lncRNA PEG10 had a higher risk to relapse and a statistically significant shorter overall survival (OS) than patients with reduced expression of lncRNA PEG10. In multivariate analysis, expression level of lncRNA PEG10 was found to be an independent prognostic factor for both progression-free survival and OS in glioma patients.

Conclusions:
LncRNA PEG10 served as an oncogene and played crucial roles in the progression of glioma. Molecular therapy targeted on lncRNA PEG10 might bring significant benefits to the clinical outcome of malignant glioma.