bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exostosin1 as a novel prognostic and predictive biomarker for squamous cell lung carcinoma: A study based on bioinformatics analysis
Authors: Wu Disheng , Huo Chao , Jiang Siyu , Huang Yanxia , Fang Xuehong , Liu Jun , Yang Min , Ren Jianwei , Xu Bilian , Liu Yi 
Published: December 2020

AbstractThe exostosin (EXT) protein family is involved in diverse human diseases. However, the expression and prognostic value of EXT genes in human lung squamous cell carcinoma (LUSC) is not well understood. In this study, we analyzed the association between expression of EXT1 and EXT2 genes and survival in patients with LUSC using bioinformatics resources such as Oncomine and The Cancer Genome Atlas (TCGA) databases, the Gene Expression Profiling Interactive Analysis (GEPIA) server and Kaplan–Meier plotter. Furthermore, regulatory microRNAs (miRNAs) were predicted for EXT1 and used to establish a potential miRNA‐messenger RNA (mRNA) regulation network for LUSC using the ENCORI platform. We observed that EXT1 and EXT2 expression levels were higher in LUSC than those in normal tissues. However, only EXT1 expression was significantly associated with poor overall survival (OS) in LUSC patients. Functional annotation enrichment analysis showed that genes co‐expressed with the EXT1 gene were enriched in biological processes such as cell adhesion and migration, and KEGG pathways such as extracellular matrix receptor interactions, complement and coagulation cascades, and cell death. Furthermore, three miRNAs, hsa‐mir‐190a‐5p, hsa‐mir‐195‐5p, and hsa‐mir‐490‐3p, were identified to be potentially involved in the regulation of EXT1. In summary, we identified EXT1 expression as a novel potential prognostic marker for human LUSC and the regulatory miRNAs that could possibly contribute to the prognosis of the disease.
KeyFrame extraction for human motion capture data via multiple binomial fitting
Authors: Xu Chenxu , Yu Wenjie , Li Yanran , Lu Xuequan , Wang Meili , Yang Xiaosong 
Published: December 2020

AbstractIn this paper, we make two contributions. The first is to propose a new keyframe extraction algorithm, which reduces the keyframe redundancy and reduces the motion sequence reconstruction error. Secondly, a new motion sequence reconstruction method is proposed, which further reduces the error of motion sequence reconstruction. Specifically, we treated the input motion sequence as curves, then the binomial fitting was extended to obtain the points where the slope changes dramatically in the vicinity. Then we took these points as inputs to obtain keyframes by density clustering. Finally, the motion curves were segmented by keyframes and the segmented curves were fitted by binomial formula again to obtain the binomial parameters for motion reconstruction. Experiments show that our methods outperform existing techniques, in terms of reconstruction error.
Self‐expanding transcatheter aortic valve infolding: Current evidence, diagnosis, and management
Authors: Ancona Marco Bruno , Beneduce Alessandro , Romano Vittorio , Buzzatti Nicola , Russo Filippo , Bellini Barbara , Ferri Luca Angelo , Agricola Eustachio , Landoni Giovanni , Scandroglio Anna Mara , Chieffo Alaide , Montorfano Matteo 
Published: December 2020

AbstractBackgroundProsthetic valve infolding is a rare but severe complication of transcatheter aortic valve implantation (TAVI) with self‐expanding valves. However, currently available clinical data are limited and fragmented.ObjectivesThis report aims to provide a comprehensive overview of this complication focusing on predisposing factors, clinical presentation, diagnostic findings, treatment and clinical outcomes.MethodsA systematic review of the literature was performed to identify cases of infolding occurring during TAVI with self‐expanding valves published until August 2020. These data were pooled with all the retrospectively identified infolding cases occurred at San Raffaele Scientific Institute between December 2014 and August 2020.ResultsA total of 34 cases were included. Among patients with available data, 38% received a first‐generation CoreValve, and 62% a second‐generation Evolut R (82%) or Evolut PRO (18%). Infolding occurred mostly with ≥29‐mm valves (94%). Predisposing factors included resheathing of a second‐generation valve (82%), heavy calcification of the native valve (65%), lack of predilatation (16%), Sievers type‐1 bicuspid aortic valve (11%), and improper valve loading (5%). Infolding resulted in severe PVL causing hemodynamic instability (29%) or cardiac arrest (12%). Postdilatation was the treatment strategy in 68%, while prosthesis replacement with a new device in 23% of cases. Device success rate was 82%. Death and stroke occurred in 3% and 12% of cases.ConclusionsProsthetic valve infolding is typically observed after resheathing of a large‐size self‐expanding TAVI. When infolding is timely diagnosed, prosthesis removal and replacement should be pursued. Further studies are required to precisely define predisposing factors to prevent this complication.
Insight into the Metal‐Support Interactions between Ruthenium and Nanodiamond‐derived Carbon material for CO Oxidation
Authors: Zhang Liyun , Wu Kuang‐Hsu , Ding Yuxiao , Shi Wen , Liu Siyang , Niu Yiming , Zhang Bingsen 
Published: December 2020

AbstractFor supported metal catalysts, metal‐support interactions (MSI) are vital for their catalytic performance, which can be regulated by controlling surface structures of supports. In this work, two kinds of nanodiamond (ND)‐derived carbon materials, i. e. ND@graphene (ND@G) and onion‐like carbon (OLC), were applied to support Ru catalyst. The characterization results show that compared with OLC supported Ru catalyst (Ru/OLC), ND@G supported Ru catalyst (Ru/ND@G) exhibits a higher Ru dispersity, large amount of nanoclusters and Ru single atoms with positive charges dispersing on the surface of ND@G, indicating a stronger MSI in Ru/ND@G. Ru/ND@G favors twin CO adsorbates, while Ru/OLC favors linear adsorbates. For CO oxidation reaction, it was found that Ru/OLC with more metallic Ru NPs exhibited higher catalytic activity compared to Ru/ND@G. Moreover, Ru/OLC showed better reusability and stability compared to Ru/ND@G during CO oxidation reaction. This work highlights the importance of having an adequate rather than an excessively strong MSI for some catalytic systems.
Structural Exploration of Multilayered Ionic Liquid/Ag Electrode Interfaces by Atomic Force Microscopy and Surface‐Enhanced Raman Spectroscopy
Authors: Zhang Meng , Duan Sai , Luo Siheng , Zhong Yunxin , Yan Jiawei , Liu Guokun , Mao Bingwei , Tian Zhongqun 
Published: December 2020

AbstractExperimentally and theoretically exploring the detailed structure of ionic liquid/electrode interfaces is challenging. Progress has been made in understanding inner two‐dimensional ionic liquid/electrode interfaces. However, few studies have investigated the multilayer structure of the ionic liquid/electrode interface, which requires high spatial and chemical resolution. Here, using the interface structure of 1‐ethyl‐3‐methylimidazolium bis‐trifluoromethylsulfonyl imide (EMITFSI)/Ag (111) as a model system, its multilayer structure was revealed by in situ atomic force microscopy (AFM) and molecular dynamics simulations. The potential‐dependent interfacial orientations of the first and second EMITFSI layers were determined by electrochemical shell‐isolated nanoparticles‐enhanced Raman spectroscopy (SHINERS) on Ag(111) and surface‐enhanced Raman spectroscopy (SERS) on Ag nanoparticles. This work shows that a clear multilayer structure of ionic liquid/electrode interfaces can be explored by combining multiple techniques.
PD‐1 blockade using pembrolizumab in adolescent and young adult patients with advanced bone and soft tissue sarcoma
Authors: Scheinberg Tahlia , Lomax Anna , Tattersall Martin , Thomas David , McCowage Geoff , Sullivan Michael , Karim Rooshdiya , Luk Peter P. , Mahar Annabelle , Bonar Fiona , Bhadri Vivek A. 
Published: December 2020

AbstractBackgroundSarcomas represent 10%–15% of cancers in adolescent and young adult (AYA) patients, and survival for those with metastatic disease or relapse is poor. Immunotherapy with checkpoint inhibition has improved outcomes in multiple tumor types, but data in advanced sarcomas, particularly within the AYA population, are limited.AimWe aim to evaluate response and toxicity for AYA patients with sarcoma treated with pembrolizumab.Methods and resultsWe retrospectively reviewed AYA patients with advanced bone and soft tissue sarcoma who received self‐funded pembrolizumab between May 2015 and January 2019. Eighteen patients were identified. One patient with Ewing sarcoma had a sustained complete response to therapy. Two patients with alveolar soft part sarcoma received a clinical benefit from pembrolizumab: one had a radiological partial response with an excellent clinical response and one patient achieved stable disease. Four patients died of disease prior to first scheduled assessment and thus were not evaluable. The remaining eleven patients had progressive disease.ConclusionThe role of immunotherapy in AYA sarcoma warrants further investigation. Biomarkers of response need to be further evaluated in order to guide patient selection.
Prognostic and therapeutic considerations of antibodies against c‐ter apolipoprotein A‐1 in the general population
Authors: Vuilleumier Nicolas , Antiochos Panagiotis , Marques‐Vidal Pedro , Pagano Sabrina , Virzi Julien , Satta Nathalie , Hartley Oliver , Gaertner Hubert , Brandt Karim J , Burger Fabienne , Montecucco Fabrizio , Waeber Gerard , Mach François , Vollenweider Peter 
Published: December 2020

AbstractObjectivesAutoantibodies against apolipoprotein A1 (anti‐apoA1 IgGs) and its C‐terminal region (cter apoA1) have emerged as an independent biomarker for cardiovascular disease. Cter apoA1 mimetic peptides were shown to reverse the deleterious anti‐apoA1 IgG effects in vitro. We evaluated the association of anti‐cter apoA1 IgGs with overall mortality in the general population and tested the ability of a cter apoA1 mimetic peptide to reverse the anti‐apoA1 IgG‐induced inflammatory response and mortality in vitro and in vivo, respectively.MethodsAnti‐cter apoA1 IgGs were measured in serum samples of 6386 participants of the CoLaus study of which 5220 were followed for a median duration of 5.6 years. The primary outcome was overall mortality. The peptide inhibitory concentration 50% (IC50) was determined in vitro on HEK‐Blue‐4 and RAW cells. ApoE−/− mice were exposed to 16 weeks of anti‐apoA1IgG passive immunisation with and without peptide co‐incubation.ResultsAnti‐cter apoA1 IgGs were associated with higher interleukin 6 levels and independently predicted overall mortality; an increase of one standard deviation of anti‐cter apoA1 IgG level was associated with an 18% increase in mortality risk (hazard ratio: 1.18, 95% confidence interval: 1.04–1.33; P = 0.009). The cterApoA1 analogue reversed the antibody‐mediated inflammatory response with an IC50 of 1 µm in vitro but did not rescue the significant anti‐apoA1 IgG‐induced mortality rate in vivo (69% vs. 23%, LogRank P = 0.02).ConclusionAnti‐cter apoA1 IgG independently predicts overall mortality in the general population. Despite being effective in vitro, our cter apoA1 analogue did not reverse the anti‐apoA1 IgG‐induced mortality in mice. Our data suggest that these autoantibodies are not readily treatable through cognate peptide immunomodulation.
Ultrathin Metal Silicate Hydroxide Nanosheets with Moderate Metal–Oxygen Covalency Enables Efficient Oxygen Evolution
Authors: Zhu Jiexin , Li Shikun , Zhuang Zechao , Gao Shan , Hong Xufeng , Pan Xuelei , Yu Ruohan , Zhou Liang , Moskaleva Lyudmila V. , Mai Liqiang 
Published: December 2020

AbstractExploring efficient, cost‐effective, and durable electrocatalysts for electrochemical oxygen evolution reaction (OER) is pivotal for the large‐scale application of water electrolysis. Recent advance has demonstrated that the activity of electrocatalysts exhibits a strong dependence on the surface electronic structure. Herein, a series of ultrathin metal silicate hydroxide nanosheets (UMSHNs) M3Si2O5(OH)4 (M = Fe, Co, and Ni) synthesized without surfactant are introduced as highly active OER electrocatalysts. Cobalt silicate hydroxide nanosheets show an optimal OER activity with overpotentials of 287 and 358 mV at 1 and 10 mA cm−2, respectively. Combining experimental and theoretical studies, it is found that the OER activity of UMSHNs is dominated by the metal–oxygen covalency (MOC). High OER activity can be achieved by having a moderate MOC as reflected by a σ*‐orbital (eg) filling near unity and moderate [3d]/[2p] ratio. Moreover, the UMSHNs exhibit favorable chemical stability under oxidation potential. This contribution provides a scientific guidance for further development of active metal silicate hydroxide catalysts.
A Novel Approach to N‐Tf 2‐Aryl‐2,3‐Dihydroquinolin‐ 4(1H)‐ones via a Ligand‐Free Pd(II)‐Catalyzed Oxidative Aza‐Michael Cyclization
Authors: Kim Young Min , Yoo Hyung‐Seok , Son Seung Hwan , Kim Ga Yeong , Jang Hyu Jeong , Kim Dong Hwan , Kim Soo Dong , Park Boyoung Y. , Kim Nam‐Jung 
Published: December 2020

Abstract2‐Aryl‐2,3‐dihydroquinolin‐4(1H)‐ones have recently been identified as important structures with potent biological activities such as antitumor and antidiabetic effect. Herein, a total of 25 novel N‐Tf 2‐aryl‐2,3‐dihydroquinolin‐4(1H)‐ones were expediently synthesized via the oxidative aza‐Michael cyclization of N‐Tf‐2′‐aminodihydrochalcones by ligand‐free palladium(II) catalysis. This study presents a new synthetic approach to yield N‐Tf 2‐aryl‐2,3‐dihydroquinolin‐4(1H)‐ones, which can be easily transformed into pharmacologically interesting aza‐flavanones and other N‐heterocycles, such as quinolines and tetrahydroquinolines, in yields up to 84 %. This methodology has various advantages, which includes short reaction times under mild conditions and suitable functional group tolerance. Furthermore, a plausible mechanism was proposed and demonstrated by kinetic analysis.
Distinct element modeling of the dynamic response of a rocking podium tested on a shake table
Authors: Malomo Daniele , Mehrotra Anjali , DeJong Matthew J. 
Published: December 2020

AbstractA blind prediction contest was organized to evaluate the ability of different modeling approaches to simulate the seismic rocking response of a full‐scale four‐column podium structure. The structure was tested on a shake table, and was subjected to two bidirectional ground motion ensembles comprising 100 synthetic records each. This short communication presents the main assumptions and results from the model, developed using the distinct element method, which provided the second‐best prediction of the experimental results. A comparison of the model predictions and the experimental results demonstrates that the numerical model was generally able to reproduce the large displacements induced by the more intense ground motion ensemble, while tending to overestimate the displacements of the less intense earthquake ensemble. This overestimation of the response was reduced through the inclusion of damping in the system. However, the addition of damping greatly increased the solve time, which is problematic for a competition, and in the case of the more intense ground motion ensemble also resulted in an underprediction of the maximum response of the structure.
An experimental investigation for a hybrid phase change material‐liquid cooling strategy to achieve high‐temperature uniformity of Li‐ion battery module under fast charging
Authors: Chen Siqi , Garg Akhil , Gao Liang , Wei Xuezhe 
Published: December 2020

SummaryFast charging is significant for the convenience of long‐term driving. In this study, a hybrid‐phase change material (PCM)‐liquid cooling system is designed for a battery module with eight prismatic cells under high charging current rates. Temperature rise, temperature distribution, and energy consumption of the cooling system are measured in experiments under 3C, 2.5C, and 2C fast charging. The results indicate that the highest coolant flow rate and the largest PCM thickness cannot achieve the optimal thermal performance. Therefore, appropriate coolant flow rate and PCM thickness selection ensure the cooling performance and reduce energy mass and volume consumption. Experimental results demonstrate that the maximum temperature of the module can be decreased from 43°C to 35.6°C, 34.5°C, and 34.8°C by pure PCM, pure liquid cooling, and the hybrid PCM‐liquid cooling system under 3C fast charging; and temperature standard deviation (TSD) can be controlled within 0.9°C, 1.5°C, and 0.96°C, respectively. When the PCM thickness and coolant flow rate are set as 0.65 mm and 54 mL/min, respectively, the hybrid cooling system achieves the optimal thermal performance (maximum temperature: 34.8°C, TSD: 1°C) under 3C fast charging, and the energy consumption (459 J) can be controlled within the acceptable range.
Forecasting China's Crude Oil Futures Volatility: The Role of the Jump, Jumps Intensity, and Leverage Effect
Authors: Wang Jiqian , Ma Feng , Wahab M.I.M. , Huang Dengshi 
Published: December 2020

AbstractThis study explores the forecasting ability of jump, jump intensity, and leverage effect for an emerging futures market, China's crude oil futures market, using different kinds of HAR‐type models. From an in‐sample perspective, we find that the HAR components, monthly leverage effect, jump size, and jump intensity have positive effects on future oil volatility. Moreover, out‐of‐sample results show that a forecasting model with jump and jump intensity cannot only achieve a superior forecasting performance under low volatility level but also increase the economic value. Subsequently, we examine the effect of decompositions of jump information, the results show signed jump components can improve the accuracy. Finally, we extend our empirical analysis considering different forecast horizons, COVID‐19 pandemic, and different trading hours. Our empirical results are robust and consistent.
Advances in Solar‐Driven Hygroscopic Water Harvesting
Authors: Zhuang Shendong , Qi Heshan , Wang Xueyang , Li Xiuqiang , Liu Kai , Liu Jun , Zhang Han 
Published: December 2020

AbstractWater scarcity is one of the greatest global challenges at this time. Significant efforts have been made to harvest water from the air, due to widely available water sources present in the atmosphere. Particularly, solar‐driven hygroscopic water harvesting based on the adsorption–desorption process has gained tremendous attention because of the abundance of solar energy in combination with substantial improvements in conversion efficiency enabled by advanced sorbents, improved photothermal materials, interfacial heating system designs, and thermal management in recent years. Here, recent developments in atmospheric water harvesting are discussed, with a focus on solar‐driven hygroscopic water harvesting. The diverse structural designs and engineering strategies that are being used to improve the rate of the water production, including the design principles for sorbents with high adsorption capacity, high‐efficiency light‐to‐heat conversion, optimization of thermal management, vapor condensation, and water collection, are also explored. The current challenges and future research opportunities are also discussed, providing a roadmap for the future development of solar‐driven hygroscopic water harvesting technology.
Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches
Authors: Shi Zhimin , Zhang Zeyu , Schaffer Lana , Huang Zhi , Fu Lijuan , Head Steven , Gaasterland Terry , Wang Xiu‐Jie , Li XiaoChing 
Published: December 2020

AbstractMale juvenile zebra finches learn to sing by imitating songs of adult males early in life. The development of the song control circuit and song learning and maturation are highly intertwined processes, involving gene expression, neurogenesis, circuit formation, synaptic modification, and sensory‐motor learning. To better understand the genetic and genomic mechanisms underlying these events, we used RNA‐Seq to examine genome‐wide transcriptomes in the song control nucleus HVC of male juvenile (45 d) and adult (100 d) zebra finches. We report that gene groups related to axon guidance, RNA processing, lipid metabolism, and mitochondrial functions show enriched expression in juvenile HVC compared to the rest of the brain. As juveniles mature into adulthood, massive gene expression changes occur. Expression of genes related to amino acid metabolism, cell cycle, and mitochondrial function is reduced, accompanied by increased and enriched expression of genes with synaptic functions, including genes related to G‐protein signaling, neurotransmitter receptors, transport of small molecules, and potassium channels. Unexpectedly, a group of genes with immune system functions is also developmentally regulated, suggesting potential roles in the development and functions of HVC. These data will serve as a rich resource for investigations into the development and function of a neural circuit that controls vocal behavior.
Embryonic lethality and defective mammary gland development of activator‐function impaired conditional knock‐in Erbb3V943R mice
Authors: Senger Kate , Yuan Wenlin , Sagolla Meredith , Doerr Jonas , Bolon Brad , Ziai James , Sun Kai‐Hui , Warming Soren , Roose‐Girma Merone , Zhang Na , Tam Lucinda , Newman Robert J. , Chaudhuri Subhra , Antony Aju , Goldstein Leonard D. , Durinck Steffen , Jaiswal Bijay S. , Lafkas Daniel , Modrusan Zora , Seshagiri Somasekar 
Published: December 2020

AbstractERBB3 is a pseudokinase domain‐containing member of the ERBB family of receptor tyrosine kinases (RTKs). Following ligand binding, ERBB receptors homo‐ or hetero‐dimerize, leading to a head‐to‐tail arrangement of the intracellular kinase domains, where the “receiver” kinase domain of one ERBB is activated by the “activator” domain of the other ERBB in the dimer. In ERBB3, a conserved valine at codon 943 (V943) in the kinase C‐terminal domain has been shown to be important for its function as an “activator” kinase in vitro. Here we report a knock‐in mouse model where we have modified the endogenous Erbb3 allele to allow for tissue‐specific conditional expression of Erbb3V943R (Erbb3CKI‐V943R). Additionally, we generated an Erbb3D850N (Erbb3CKI‐D850N) conditional knock‐in mouse model where the conserved aspartate in the DFG motif of the pseudokinase domain was mutated to abolish any potential residual kinase activity. While Erbb3D850N/D850N animals developed normally, homozygous Erbb3V943R/V943R expression during development resulted in embryonic lethality. Further, tissue specific expression of Erbb3V943R/V943R in the mammary gland epithelium following its activation using MMTV‐Cre resulted in delayed elongation of the ductal network during puberty. Single‐cell RNA‐seq analysis of Erbb3V943R/V943R mammary glands showed a reduction in a specific subset of fibrinogen‐producing luminal epithelial cells.