bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications of hepatic echinococcosis: multimodality imaging approach
Authors: Greco Silvia , Cannella Roberto , Giambelluca Dario , Pecoraro Giusy , Battaglia Emanuele , Midiri Massimo , Brancatelli Giuseppe , Vernuccio Federica 
Published: December 2019

AbstractHydatid disease is a worldwide zoonosis endemic in many countries. Liver echinococcosis accounts for 60–75% of cases and may be responsible for a wide spectrum of complications in about one third of patients. Some of these complications are potentially life-threatening and require prompt diagnosis and urgent intervention. In this article, we present our experience with common and uncommon complications of hepatic hydatid cysts which include rupture, bacterial superinfection, and mass effect-related complications. Specifically, the aim of this review is to provide key imaging features and diagnostic clues to guide the imaging diagnosis using a multimodality imaging approach, including ultrasound (US), computed tomography (CT), magnetic resonance (MR), and endoscopic retrograde cholangiopancreatography (ERCP).
Signaling pathways involved in colorectal cancer progression
Authors: Koveitypour Zahra , Panahi Farnoush , Vakilian Mehrdad , Peymani Maryam , Seyed Forootan Farzad , Nasr Esfahani Mohammad Hossein , Ghaedi Kamran 
Published: December 2019

AbstractColorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality. Different molecular mechanisms have been attributed to the development and progress of CRC. In this review, we will focus on the mitogen-activated protein kinase (MAPK) cascades downstream of the epidermal growth factor receptor (EGFR), Notch, PI3K/AKT pathway, transforming growth factor-β (TGF-β), and Wnt signaling pathways. Various mutations in the components of these signaling pathways have been linked to the development of CRC. Accordingly, numerous efforts have been carried out to target the signaling pathways to develop novel therapeutic approaches. Herein, we review the signaling pathways involved in the incidence and progression of CRC, and the strategies for the therapy targeting components of signaling pathways in CRC.
Data compression in ViSAR sensor networks using non-linear adaptive weighting
Authors: Khosravi Mohammad R. , Samadi Sadegh 
Published: December 2019

AbstractNowadays, industrial video synthetic aperture radars (ViSARs) are widely used for aerial remote sensing and surveillance systems in smart cities. A main challenge of a group of networked ViSAR sensors in an IoT-based environment is low bandwidth of wireless links for communicating big video data. In this research, we propose a non-linear statistical estimator for adaptive reconstruction of compressed ViSAR data. Our proposed reconstruction filter is based on an adaptively generated non-linear weight mask of spatial observations. It can strongly outperform several conventional and well-known reconstruction filters for three different video samples.
Weight loss interventions for Hispanic women in the USA: a protocol for a systematic review
Authors: Morrill Kristin E. , Lopez-Pentecost Melissa , Ballesteros Guadalupe , Pfander Jeanne L. , Hingle Melanie D. , Klimentidis Yann C. , Thomson Cynthia A. , Garcia David O. 
Published: December 2019

Abstract
Background
In the U.S., Hispanic women experience a disproportionate rate of obesity and obesity-related chronic diseases. At the same time, Hispanic women remain considerably underrepresented in behavioral weight loss interventions. The purpose of this review is to systematically evaluate the evidence related to the effectiveness of weight loss interventions among Hispanic women in the U.S. This review will identify elements of successful weight loss interventions as well as areas for future research.

Methods/Design
The following databases will be searched to identify all relevant articles (from inception onwards): PubMed, Embase, Scopus, Web of Science (Science Citation Index and Social Sciences Citation Index), PsycINFO, CINAHL, Chicano Database, SPORTDiscus, CAB Abstracts, and Google Scholar. We will include randomized controlled trials and quasi-experimental studies of adult women (> 18 years) from Hispanic/Latino background living in the United States. Eligible interventions will target weight-related behaviors (including diet, physical activity, behavior modification and/or their combinations). The review’s primary outcome will be weight change (expressed as change in lbs/kg or body mass index (BMI) (kg/m2)). Three reviewers will independently screen and select data and two will extract data. The methodological quality (or risk of bias) of individual studies will be appraised using the Effective Public Health Practice Project Quality Assessment Tool. A narrative synthesis will describe quality and content of the evidence.

Discussion
The aim of this systematic review is to critically examine existing weight loss interventions for Hispanic women in the U.S. and provide quality evidence for the effectiveness of these interventions on weight loss. Further, this review seeks to identify characteristics of effective interventions and suggest future directions for research efforts targeting weight loss in this population. This review will inform the development of future weight loss interventions for this population.

Systematic review registration
PROSPERO CRD42019119094
Quality of life and well-being from the perspective of patients on opioid agonist maintenance treatment: study protocol for a systematic review of qualitative research and a scoping review of measures
Authors: Solà Ivan , Trujols Joan , Ribalta Elisa , Alcaraz Saul , Robleda Gemma , Selva Olid Clara , Pérez de los Cobos José 
Published: December 2019

Abstract
Background
Opioid agonist maintenance treatment (OAMT) is a first-line treatment for heroin dependence, but its effectiveness has been assessed primarily through clinical outcomes with a limited attention to patient perspectives. Despite the increased use of patient reported outcome measures their patient-centeredness is highly questionable. This is the protocol of a systematic review of qualitative research on how OAMT users construct the meaning of their quality of life and well-being and a scoping review of instruments that measure these domains.

Methods
We will conduct a systematic review of qualitative research exploring the views of quality of life of patients on OAMT (registration number CRD42018086490). According pre-specified eligibility criteria, we will include studies from a comprehensive search of bibliographical databases from their inception. We will extract data from included studies and assess their risk of bias with the CASP appraisal criteria, and will implement a thematic analysis to generate a set of interpretative analytical themes ascertaining their confidence using the CERQual approach. We will implement similar methods to conduct a scoping review to assess to what extent the existing measures of these domains were focused on user’s views, assessing their validity using the COSMIN methodology, and summarizing their characteristics and level of patient centeredness.

Conclusion
The findings from the reviews will contribute to obtain a genuine understanding of the perspective from users on OAMT regarding their perception of well-being and quality of life and will likely lead to greater patient centeredness when assessing such variables, which in turn may contribute to a more patient-centered care.
A best proximity point theorem for special generalized proximal β-quasi contractive mappings
Authors: Ayari M. Iadh , Jaradat M. M. M. , Mustafa Z. 
Published: December 2019

AbstractIn this paper, we obtain some best proximity point results for a new class of non-self mappings $T:A \longrightarrow B$T:A⟶B called special generalized proximal β-quasi contractive. Our result is illustrated by an example. Several consequences are derived.
Clinicopathologic characterization and abnormal autophagy of CSF1R-related leukoencephalopathy
Authors: Tian Wo-Tu , Zhan Fei-Xia , Liu Qing , Luan Xing-Hua , Zhang Chao , Shang Liang , Zhang Ben-Yan , Pan Si-Jian , Miao Fei , Hu Jiong , Zhong Ping , Liu Shi-Hua , Zhu Ze-Yu , Zhou Hai-Yan , Sun Suya , Liu Xiao-Li , Huang Xiao-Jun , Jiang Jing-Wen , Ma Jian-Fang , Wang Ying , Chen Shu-Fen , Tang Hui-Dong , Chen Sheng-Di , Cao Li 
Published: December 2019

Abstract
Background
CSF1R-related leukoencephalopathy, also known as hereditary diffuse leukoencephalopathy with spheroids (HDLS), is a rare white-matter encephalopathy characterized by motor and neuropsychiatric symptoms due to colony-stimulating factor 1 receptor (CSF1R) gene mutation. Few of CSF1R mutations have been functionally testified and the pathogenesis remains unknown.

Methods
In order to investigate clinical and pathological characteristics of patients with CSF1R-related leukoencephalopathy and explore the potential impact of CSF1R mutations, we analyzed clinical manifestations of 15 patients from 10 unrelated families and performed brain biopsy in 2 cases. Next generation sequencing was conducted for 10 probands to confirm the diagnosis. Sanger sequencing, segregation analysis and phenotypic reevaluation were utilized to substantiate findings. Functional examination of identified mutations was further explored.

Results
Clinical and neuroimaging characteristics were summarized. The average age at onset was 35.9 ± 6.4 years (range 24–46 years old). Younger age of onset was observed in female than male (34.2 vs. 39.2 years). The most common initial symptoms were speech dysfunction, cognitive decline and parkinsonian symptoms. One patient also had marked peripheral neuropathy. Brain biopsy of two cases showed typical pathological changes, including myelin loss, axonal spheroids, phosphorylated neurofilament and activated macrophages. Electron microscopy disclosed increased mitochondrial vacuolation and disorganized neurofilaments in ballooned axons. A total of 7 pathogenic variants (4 novel, 3 documented) were identified with autophosphorylation deficiency, among which c.2342C > T remained partial function of autophosphorylation. Western blotting disclosed the significantly lower level of c.2026C > T (p.R676*) than wild type. The level of microtubule associated protein 1 light chain 3-II (LC3-II), a classical marker of autophagy, was significantly lower in mutants expressed cells than wild type group by western blotting and immunofluorescence staining.

Conclusions
Our findings support the loss-of-function and haploinsufficiency hypothesis in pathogenesis. Autophagy abnormality may play a role in the disease. Repairing or promoting the phosphorylation level of mutant CSF1R may shed light on therapeutic targets in the future. However, whether peripheral polyneuropathy potentially belongs to CSF1R-related spectrum deserves further study with longer follow-up and more patients enrolled.

Trial registration
ChiCTR, ChiCTR1800015295. Registered 21 March 2018.
Effects of dietary menthol-rich bioactive lipid compounds on zootechnical traits, blood variables and gastrointestinal function in growing sheep
Authors: Patra Amlan K. , Geiger Sebastian , Schrapers Katharina T. , Braun Hannah-Sophie , Gehlen Heidrun , Starke Alexander , Pieper Robert , Cieslak Adam , Szumacher-Strabel Malgorzata , Aschenbach Jörg R. 
Published: December 2019

Abstract
Background
The present study aimed at investigating the influence of 90% menthol-containing plant bioactive lipid compounds (PBLC, essential oils) on growth performance, blood haematological and biochemical profile, and nutrient absorption in sheep. Twenty-four growing Suffolk sheep were allotted into three dietary treatments: Control (without PBLC), lower dose of PBLC (PBLC-L; 80 mg/d) and higher dose of PBLC (PBLC-H; 160 mg/d). Sheep in all groups were fed meadow hay ad libitum plus 600 g/d of concentrate pellets for 28 d.

Results
Average daily gain was not affected by treatment. Feeding of PBLC increased hay and total feed intake per kg body weight (P < 0.05). Counts of total leucocytes, lymphocytes and monocytes were not different among treatments. However, neutrophil count decreased (P < 0.05) in PBLC-H with a similar trend in PBLC-L (P < 0.10). Concentrations of glucose, bilirubin, triglycerides, cholesterol, urea and magnesium in serum were not different among sheep fed different doses of PBLC. However, serum calcium concentration tended to increase in PBLC-H (P < 0.10) and serum concentrations of aspartate & asparagine (P < 0.01) and glutamate & glutamine (P < 0.05) increased linearly with increasing PBLC dose. In ruminal epithelia isolated from the rumen after killing, baseline conductance (Gt; P < 0.05) and short-circuit current (Isc; P < 0.01) increased in both PBLC groups. Ruminal uptakes of glucose and methionine in the presence of Na+ were not affected by the dietary PBLC supplementation. In the absence of Na+, however, glucose and methionine uptakes increased (P < 0.05) in PBLC-H. In the jejunum, Isc tended to increase in PBLC-H (P < 0.10), but baseline Gt was not affected. Intestinal uptakes of glucose and methionine were not influenced by PBLC in the presence or absence of Na+.

Conclusion
The results suggest that menthol-rich PBLC increase feed intake, and passive ion and nutrient transport, the latter specifically in the rumen. They also increased serum concentrations of urea precursor amino acids and tended to increase serum calcium concentrations. Future studies will have to show whether some of these findings might be commonly linked to a stimulation of transient receptor potential (TRP) channels in the gastrointestinal tract.
Identity, stigma, and HIV risk among transgender women: a qualitative study in Jiangsu Province, China
Authors: Yan Zi-Han , Lin Jessica , Xiao Wen-Jing , Lin Keh-Ming , McFarland Willi , Yan Hong-Jing , Wilson Erin 
Published: December 2019

Abstract
Background
Transgender women have multiple disparities globally, including social rejection and stigma, HIV infection and untreated mental health problems. However, few data on transgender women are available in China. Therefore, this study aimed to explore transgender women’s experiences on gender identity, disclosure, discrimination, transgender-specific medical care, and perceptions of HIV and sexually transmitted infections (STI) risk in China.

Methods
A qualitative study was conducted in Nanjing and Suzhou city, China in 2018. Key informant interviews (n = 14) and focus group discussions (n = 2) with diverse transgender women were implemented. Text was transcribed and translated, and Dedoose™ software was used for coding, analysis and interpretation by the research team.

Results
Chinese transgender women share experiences with transgender women worldwide, including a long and challenging identity search, stigma and discrimination, poor access to trans-specific services and unmet needs for mental health care. Features unique to them include terms used for self-identification, culturally-shaped expectations for reproduction, and ideals of placing the familial and societal welfare over personal fulfillment. Social networks of this population appear sparse, scattered, and underground. Familial rejection was experienced by nearly all respondents. Perceptions of HIV and STI risk and history of HIV testing were notably low.

Conclusions
Transgender women in China face high social rejection and discrimination along with unmet need for various types of healthcare. Scaling up transgender-specific services including gender-affirming medical care, mental health care and HIV/STI prevention are warranted to address the social, medical and mental health of transgender women in China.
The role of need satisfaction for solo self-employed individuals’ vs. employer entrepreneurs’ affective commitment towards their own businesses
Authors: Schummer Steffen E. , Otto Kathleen , Hünefeld Lena , Kottwitz Maria U. 
Published: December 2019

AbstractPersistence in self-employment is crucial for entrepreneurial activities to generate long-term economic benefits. Consequently, this research examined the commitment of the self-employed towards their business as an important determinant of persistence. However, this research treats the self-employed as one entity. Yet we assume that especially for the research on commitment the differentiation of the self-employed into solo self-employed individuals (self-employed individuals without employees) and employer entrepreneurs (self-employed individuals with employees) provides seminal insights. Thus, this study examined differences in affective commitment to (emotional attachment to and identification with) one’s business and its antecedents between these self-employment forms. We used data of German solo self-employed individuals (n = 117) and employer entrepreneurs (n = 103) from the European Working Condition Survey (EWCS 2010). A simple t test revealed that the solo self-employed individuals report lower levels of affective commitment to their business than employer entrepreneurs. Moreover, regression analyses revealed that satisfaction of the needs for autonomy and competence was more strongly related to affective commitment for the solo self-employed than that for employer entrepreneurs, whereas satisfaction of the need for relatedness was more weakly related among the solo self-employed than that the employer entrepreneurs. These results suggest that solo self-employed individuals and employer entrepreneurs not only differ in affective commitment to their businesses but also in their antecedents. Implications for research on motivational processes of the self-employed and for fostering persistence in self-employment are discussed.
Social capital and entrepreneurial intention: empirical evidence from rural community of Pakistan
Authors: Ali Amjad , Yousuf Sania 
Published: December 2019

AbstractUnderstanding the antecedents of the entrepreneurial intentions is vital in development of entrepreneurship in a region. Entrepreneurship is considered as one of the important elements of local economic development which can be used to address the issues of poverty and scarcity of livelihood opportunities in rural areas of the world. This study investigates the influence of social capital on entrepreneurial intentions in rural area of Pakistan. For this purpose, a representative sample of 325 respondents has been selected from rural community in Gilgit-Baltistan. The constructed model has been estimated using the partial least square method and the results show that social capital has significant positive impact on entrepreneurial intentions by forming perceived desirability, perceived self-efficacy, and perceived social norms towards entrepreneurship. This study recommends rural community of Pakistan should be given awareness about the potential of entrepreneurship opportunities and such awareness programs have unique advantages to various segments of rural community. Women, unemployed individuals, and younger generations in particular may get the maximum benefits as people in mountainous regions have already limited earning options. In such a case, developing entrepreneurial intentions of the mountain community in Gilgit-Baltistan leads to understandings of benefits of initiating their own ventures, get economic advantages, and contribute to households’ income.
Effects of different nose types on class II treatments for female patients
Authors: Cankaya Ozkan Semih , Celebi Fatih , Bicakci Ali Altug 
Published: December 2019

Abstract
Background
The aim of this study was to evaluate the effect of different nose types on the perception of facial aesthetics following camouflage treatment and orthognathic surgery for skeletal class II female patients.

Methods
A pre-treatment profile photograph of a skeletal class II adult patient was selected from the department archive. Two constructed photographs were created to represent orthognathic surgery and camouflage treatments with the aid of computer software. A total of 18 constructed images was composed using three profiles (pre-treatment, post-camouflage, and post-orthognathic surgery) and six nose types. These photographs were shown to the three groups (orthodontists, plastic surgeons, and lay people), and they were asked to assign an attractiveness score to each photo ranging from 0 to 100, with 0 indicating the least attractive and 100 indicating the most attractive.

Results
For the convex nose profiles, anterior movement of the mandible obtained by orthognathic surgery did not result in a significant change in the scores given by the lay people. When surgical or camouflage treatment was not implemented and, instead, just rhinoplasty was performed for these profiles, there was a significant increase in the aesthetic scores given by all groups. For the straight nose profiles, orthognathic surgery increased the attractiveness scores given by all groups. Furthermore, for all the profiles, extraction treatment did not affect the aesthetic scores given by any of the groups (P > 0.05).

Conclusions
The lay people perceived that having a convex-bridged nose was a bigger problem than having a retrognathic profile. Overall, in terms of skeletal and dental orthodontic treatments, nose shape should be considered during the treatment planning process.
Severely imbalanced Big Data challenges: investigating data sampling approaches
Authors: Hasanin Tawfiq , Khoshgoftaar Taghi M. , Leevy Joffrey L. , Bauder Richard A. 
Published: December 2019

AbstractSevere class imbalance between majority and minority classes in Big Data can bias the predictive performance of Machine Learning algorithms toward the majority (negative) class. Where the minority (positive) class holds greater value than the majority (negative) class and the occurrence of false negatives incurs a greater penalty than false positives, the bias may lead to adverse consequences. Our paper incorporates two case studies, each utilizing three learners, six sampling approaches, two performance metrics, and five sampled distribution ratios, to uniquely investigate the effect of severe class imbalance on Big Data analytics. The learners (Gradient-Boosted Trees, Logistic Regression, Random Forest) were implemented within the Apache Spark framework. The first case study is based on a Medicare fraud detection dataset. The second case study, unlike the first, includes training data from one source (SlowlorisBig Dataset) and test data from a separate source (POST dataset). Results from the Medicare case study are not conclusive regarding the best sampling approach using Area Under the Receiver Operating Characteristic Curve and Geometric Mean performance metrics. However, it should be noted that the Random Undersampling approach performs adequately in the first case study. For the SlowlorisBig case study, Random Undersampling convincingly outperforms the other five sampling approaches (Random Oversampling, Synthetic Minority Over-sampling TEchnique, SMOTE-borderline1 , SMOTE-borderline2 , ADAptive SYNthetic) when measuring performance with Area Under the Receiver Operating Characteristic Curve and Geometric Mean metrics. Based on its classification performance in both case studies, Random Undersampling is the best choice as it results in models with a significantly smaller number of samples, thus reducing computational burden and training time.