bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detailed Mechanistic Pattern in Halogen Dance Reactions of Iodothiophenes
Authors: Sakhaee Nader , Sakhaee Sahar , Doustkhah Esmail , mobaraki Akbar 
Published: November 2020

Background::
Synthetic chemists have utilized base catalyzed halogen dance reactions
ever since their discovery by Bunnet et al. Many modifications under various conditions have enabled
synthetic chemists to build substituted heterocyclic targets with rich structural diversity.

Methods::
Using DFT-Cam-B3LYP/ land2dz computations and focusing on Hannes Frohlich et al.
Halogen dance reactions of iodothiophenes, a new iodo-bridged transition state is proposed. This iodo-
bridged TS was then used to put forth 8 possible isomerization as well as 8 possible disproportionation
paths.

Results & Discussion:
All mechanistic pathways were then thoroughly investigated based on TS’s
energy and protonation/deprotonation steps to find the most suitable pathways. Collectively, these
mechanistic pathways were joined like a jigsaw puzzle to yield, for the first time, a comprehensive
cascade-like pattern for base-catalyzed halogen dance in iodothiophenes.

Conclusion::
The present work may shed light on a dynamic domino mechanism that may well
dominate the organic chemistry of iodothiophenyl anions. Trends like this may reveal mechanistic
pathways in base digestion of halogenated aromatic compounds in CS2.
Effect of follicular growth promoters on timed artificial insemination in dairy cows.
Authors: Câmara-de-Almeida Ítalo , Albani-Oliveira Fabrício , Madureira Ana P , Barioni Graziela , Alves-Torres Ciro A 
Published: November 2020

Objective. To evaluate the efficiency of equine chorionic gonadotropin (eCG) and follicle stimulating hormone (FSH) on the pregnancy rate of crossbred cows from different body condition score (BCS) in the postpartum period in timed artificial insemination (TAI). Material and methods. The cows were subjected to the same hormone protocol: Day zero (D0), progesterone-release intravaginal device (PRID) and 2 mg estradiol benzoate (EB); D8, withdrawal of PRID, application 0.150 mg of prostaglandin. On D8, the animals were distributed into three treatments: 1 – (TeCG; n = 98) injection of 300 IU eCG; 2 – (TFSH; n = 84) injection of 20 mg of FSH and; 3 – (Control; n = 115) without further treatment. On D9, all animals received 1 mg of EB; D10, TAI of all the cows. After 30 days from TAI, ultrasound diagnosis of pregnancy was performed. Results. Pregnancy rate did not differ among eCG (52.04%), FSH (40.47%), and Control (40.00%) treated cows (p>0.05). In cows with low body condition, the pregnancy rate was higher (p<0.05) for cows treated with eCG (41.46%) when compared to FSH (18.18%) and Control (17.07%) cows. The postpartum interval among treatments was similar (p>0.05) (35–65 or 66–95days). Conclusions. The use of eCG or FSH did not result in an increase in the pregnancy rate when compared to the control treatment; however, eCG improved the pregnancy rate of cows with low body condition scores.
Potential of development of economic cooperation between Russia and EAEU and CIS countries
Authors: Migranyan A. A. 
Published: November 2020

The article examines the peculiarities of the economic situation and the potential for the development of regional integration of Russia and the CIS and EAEU countries. The complexity of the current economic downturn against the backdrop of the COVID-19 pandemic and the turbulence of world energy markets has a mixed impact not only on the economic downturn in the countries of the region, but also on integration processes, their nature and development prospects. In this context, the study of a set of interrelated processes from the point of view of the formation of economic policies of countries, their foreign economic guidelines and goals is relevant. At the same time, the methodology for integrated assessment of the development potential of regional integration is based on the following assumptions: the need to coordinate and develop economic development strategies and geopolitical strategies; creating the attractiveness of the Russian economy as a core of integration; development of common energy markets as the basic platform for integration in the EAEU.
Hubungan religiusitas, depresi, dan kecemasan Matematika Mahasiswa
Authors: Purnomo Andreas Wisnu Adi , Loekmono J.T. Lobby 
Published: November 2020

Penelitian ini bertujuan untuk mengetahui ada tidaknya hubungan yang signifikan antara variabel religiusitas, depresi dan kecemasan matematika secara bersamaan pada mahasiswa Fakultas Teknik Informatika Universitas Kristen Satya Wacana (FTI UKSW) angkatan 2017 penerima beasiswa dari pemerintah Kabupaten Bengkayang. Penelitian ini berjenis penelitian korelasional dengan jumlah responden sebanyak 34 individu. Teknik sampling yang digunakan adalah Total sampling, yaitu semua populasi dijadikan sampel. Teknik analisis yang digunakan ialah korelasi ganda dengan koefisien signifikansi Sig< 0,05Â dinyatakan ada hubungan signifikan. Berdasarkan hasil analisis didapati tidak ada hubungan yang signifikan antara variabel religiusitas, depresi dan kecemasan matematika secara bersamaan. Hal ini dilihat dari koefisien signifikansi korelasi berganda senilai 0,601> 0,05.Â Abstract: This study aims to determine whether there is a significant relationship between the variables of religiosity, depression and math anxiety simultaneously in the Satya Wacana Christian University (SWCU FTI) Informatics Engineering students class of 2017 who are scholarship recipients from the Bengkayang Regency government. This research is a correlational research type with the number of respondents as many as 34 individuals. The sampling technique used was total sampling, in which all populations were sampled. The analysis technique used is multiple correlation with a significance coefficient of Sig <0.05, it is stated that there is a significant relationship. Based on the results of the analysis, it was found that there was no significant relationship between the variables of religiosity, depression and math anxiety simultaneously. This can be seen from the multiple correlation significance coefficient of 0.601> 0.05.
Pemberdayaan Remaja Masjid di masa pandemi Covid-19 melalui workshop dan simulasi Konseling Sebaya
Authors: Sari Ratna , Saleh M Nurul Ikhsan , Rahman Diana Nur , Aisah Anita 
Published: November 2020

Pandemi Covid-19 membuat ruang gerak semua orang menjadi terbatas, termasuk pada diri remaja. Remaja yang semestinya bebas untuk bersosialisasi dan berinteraksi, kini terbatasi oleh ruang-ruang online. Remaja disibukkan dengan sekolah online yang membuat lebih sibuk di dunia maya daripada di dunia nyata. Hal ini, tidak hanya menimbulkan kebosanan bagi remaja, melainkan juga berefek pada kesehatan mental remaja, sehingga membutuhkan rekan yang dapat membantu permasalahan yang dialami. Penelitian ini bermaksud untuk mengkaji efektifitas metode workshop dan simulasi sebagai wahana pemberdayaan remaja masjid dalam peningkatan skill konselor sebaya di masa pandemi Covid-19. Pendekatan penelitian mengkombinasikan metode kuantitatif dan kualitatif atau mixed method. Metode pengumpulan data berupa observasi serta wawancara terstruktur, pretest dan posttest. Responden dalam penelitian ini adalah remaja masjid yang berjumlah 22 orang. Data kuantitatif dianalisis dengan statistik deskriptif teknik frekuensi. Adapun data kualitatif dianalisis menggunakan teknik Miles dan Huberman, yaitu; reduksi data, verifikasi data dan penyajian data. Hasil dari penelitian ini adalah berupa peningkatan pengetahuan dan kompetensi yang ditunjukkan remaja masjid setelah mengikuti rangkaian workshop konselor sebaya. Responden yang memiliki pemahaman yang baik pada materi posttest sebesar 87% dan dalam simulasi responden mampu melakukan praktik konseling sebaya sesuai panduan.Â Abstract: The Covid 19 pandemic limited everyone's space, including adolescents. Online spaces now limit youths who should be free to socialize and interact. Adolescents are preoccupied with online schools, which make them busier in cyberspace than in the real world. This case causes boredom for adolescents and affects their mental health, thus requiring partners to help their problems. This study intends to examine the effectiveness of workshop and simulation methods to empower mosque youth in increasing peer counselor skills during the Covid-19 pandemic. The research approach combines quantitative and qualitative methods (mixed method). The data collection methods were observation, a structured interview, pretest and posttest. Respondents in this study were 22 mosque youths. The quantitative data were analyzed by using descriptive statistics with frequency technique. The qualitative data were analyzed using the Miles and Huberman technique consisting of data reduction, data verification, and data presentation. This study's result is increased knowledge and competence shown by mosque youth after participating in peer counselor workshops and simulations. Respondents who had a good understanding of the posttest material were 87%, and in the simulation, respondents were able to practice peer counseling according to the guidelines.
TRADISI BERSIH KALI (STUDI KEARIFAN LOKAL DAN POTENSINYA SEBAGAI SUMBER PEMBELAJARAN IPS SD
Authors: Sunyoto S 
Published: November 2020

<p>Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan nilai kearifan lokal yang terkandung di dalam tradisi bersih kali di Desa Baosan Kidul Kecamatan Ngrayun Kabupaten Ponorogo dan potensinya sebagai sumber pembelajaran IPS SD. Penelitian ini menggunakan pendekatan kualitatif etnografi dengan memanfaatkan sumber data primer dan sumber data sekunder. Informan ditentukan dengan teknik purposive sampling. Data primer diperoleh dari informan melalui wawancara, observasi dan pencatatan dokumentasi. Sedangkan analisa data analisis data kualitatif menurut Miles dan Huberman yang meliputi reduksi data (data reduction), penyajian data (data display), serta penarikan kesimpulan dan verifikasi (<em>conclusion drawing/verification</em>). Hasil penelitian memberi gambaran bahwa Tradisi Bersih Kali adalah sebuah tradisi turun temurun yang dimiliki oleh masyarakat Desa Baosan Kidul, yang memiliki nilai-nilai kearifan lokal diantaranya: tanggung jawab, rela berkorban, persatuan atau kerukunan, gotong royong, hormat menghormati, religi, spiritual, dan estetika. Oleh karenanya Tradisi Bersih Kali ini berpotensi sebagai salah satu sumber pembelajaran kajian Mata Pelajaran IPS kelas 5 Sekolah Dasar.</p><p> </p><p> </p>
Modeling of dynamic mosaicism on ring chromosomes in human fibroblasts and IPSCS
Authors: Никитина Т.В. , Кашеварова А.А. , Гридина М.М. , Хабарова А.А. , Мензоров А.Г. , Яковлева Ю.С. , Васильев С.А. , Пристяжнюк И.Е. , Минина Ю.М. , Распопова М.А. , Дериглазов Д.А. , Серов О.Л. , Лебедев И.Н. 
Published: November 2020

Митотическая нестабильность кольцевых хромосом может приводить к появлению клеточных клонов с различной генетической структурой. В качестве модели нестабильности кольцевых хромосом в митозе мы использовали фибробласты от пациентов с r(8), r(13), r(18) и r(22) и полученные из них индуцированные плюрипотентные стволовые клетки (ИПСК). Линии ИПСК с r(22) имели относительно стабильный кариотип на протяжении десятков (до 60) пассажей и сохраняли неизменную структуру кольцевой хромосомы. Кариотип линий ИПСК с r(8) и r(18) на ранних пассажах стабильный, планируется его изучение на поздних пассажах. Наибольшее разнообразие кариотипа выявлено в линиях ИПСК с r(13), в которых наблюдали различные перестройки и выраженную клеточную гетерогенность. Определение факторов, влияющих на митотическую стабильность кольцевых хромосом, может иметь значение для консультирования пациентов.
Mitotic instability of ring chromosomes can lead to the appearance of cell clones with different genetic structure. IPSCs from fibroblasts of patients with r(8), r(13), r(18), and r(22) were used as a model of ring chromosomes mitotic behavior. Karyotypes of iPSC lines with r(8) and r(18) have so far been evaluated only in the early passages, lines with r(22) have maintained a relatively stable karyotype up to 60 passages. The occurrence of rearrangements and cellular heterogeneity was found characteristic for r(13) iPSCs. The determination of factors affecting the ring chromosomes mitotic stability would be beneficial for the patient’s prognosis.
Clinical and molecular-genetics diagnosis of microdeletion Xp11.4
Authors: Миньженкова М.Е. , Маркова Ж.Г. , Маркова Т.В. , Шилова Н.В. 
Published: November 2020

Представлены клинические и молекулярно-генетические результаты обследования девочки с задержкой психомоторного, речевого и физического развития, микроцефалией, гипоплазией моста и мозжечка. Хромосомный микроматричный анализ позволил выявить делецию Хр11.4, затрагивающую ген CASK, который ассоциирован с клиническими проявлениями MICPCH-синдрома (mental retardation and microcephaly with pontine and cerebellar hypoplasia).
Сlinical and molecular-genetic study results of a girl with developemental and psychomotor delay, lack of speech development, microcephaly, and pontocerebellar hypoplasia are presented. Chromosomal microarray analysis revealed a deletion of Xp11.4 affecting the CASK gene that is associated with clinical manifestations of MICPCH-syndrome.
Klinefelter syndrome: low level and tissue mosaicism
Authors: Требка Е.Г. 
Published: November 2020

Представлены результаты исследования FISH лимфоцитов крови и буккального эпителия 9 пациентов с синдромом Клайнфельтера и азооспермией.
The results of FISH study of lymphocytes and buccal epithelium of 9 patients with Klinefelter syndrome and azoospermia are presented.
Direct and reverse ontogenetics of chromosomal diseases
Authors: Лебедев И.Н. 
Published: November 2020

Представлен анализ современных тенденций исследований на стыке молекулярной цитогенетики, вспомогательных репродуктивных технологий и клеточного репрограммирования, направленных на моделирование патогенеза хромосомных заболеваний в динамике индивидуального развития.
Current trends in molecular cytogenetics, assisted reproductive technologies and cell reprogramming for the revelation of chromosomal diseases pathogenesis are reviewed.
A clinical case of prenatal trisomy 2
Authors: Талантова О.Е. , Серебрякова Е.А. , Малышева О.В. , Тихонов А.В. , Шабанова Е.С. , Ефимова О.А. , Чиряева О.Г. , Прохорова В.С. , Глотов А.С. 
Published: November 2020

Представлен редкий случай трисомии 2, подтверждённый пренатально на сроке 18/19 недель беременности методом хромосомного микроматричного анализа (arrayCGH) ворсин плаценты.
A rare case of trisomy 2 is presented. Prenatally at 18/19 weeks of pregnancy, confirmed by the method of chromosome microarray analysis (arrayCGH) of placental villi.
Genetic counselling for patients with fetal sex chromosome aberrations
Authors: Тарасова Ю.А. , Гнетецкая В.А. , Ижевская В.Л. , Мельникова Л.Л. 
Published: November 2020

Распространение НИПТ с оценкой риска аберраций половых хромосом привело к увеличению количества пациентов, нуждающихся в генетическом консультировании в отношении этих заболеваний. Анализ факторов, влияющих на репродуктивный выбор семьи, необходим для улучшения качества предоставляемой семье информации.
The spread of NIPTs with risk assessment of sex chromosome aberrations has led to an increase in the number of patients requiring genetic counselling for these pathologies. Analysis of factors influencing family reproductive choices is necessary to improve the quality of information provided to families.
The chromosomal microarray analysis of abortive material in pregnancy loss
Authors: Панченко Е.Г. , Канивец И.В. , Романова И.И. , Киевская Ю.К. , Кудрявцева Е.В. , Пьянков Д.В. , Коростелев С.А. 
Published: November 2020

Цель исследования - оценить распространенность и типы хромосомных аномалий (ХА) в абортивном материале за период с 2015 по 2019 гг. Методом хромосомного микроматричного анализа был исследован 2201 образец ДНК, выделенной из абортивного материала при неразвивающейся беременности. ХА были обнаружены в 49,57% случаев, из них анеуплоидии, в том числе нескольких хромосом и мозаичные формы, составляют 79,65%, триплоидия - 10,72%, другие ХА, возможно имеющие клиническое значение, - 8,62%, тетраплоидия - 1,01%. Таким образом, хромосомный микроматричный анализ может быть рекомендован как рутинный метод для поиска несбалансированных ХА в абортивном материале при невынашивании беременности.
Study objective is to assess the prevalence and pattern of chromosomal abnormalities (CAs) in products of conception (POC) for the period from 2015 to 2019. Materials and Methods: 2201 samples of POC were studied by the chromosomal microarray analysis. Study Results: CAs were detected in 49.57% of cases, of which aneuploidy, including several chromosomal and mosaic forms, were detected in 79.65%, triploidy - 10.72%, other CAs with possible clinical significance - 8.62%, tetraploidy - 1.01%. Conclusion: chromosomal microarray analysis can be recommended as a routine method for searching of unbalanced CAs in POC.
Noninvasive prenatal screening for fetal aneuploidy (NIPS): usage for obstetric and gynecological care
Authors: Барков И.Ю. , Шубина Е. , Каретникова Н.А. , Трофимов Д.Ю. 
Published: November 2020

Используемый в настоящее время в России пренатальный скрининг хромосомной патологии основан на косвенных маркерах и имеет ограничение по чувствительности и специфичности. Поэтому более перспективным является применение неинвазивного пренатального ДНК-скрининга анеуплоидий (НИПС). Целью данной работы являлась оценка возможности применения полногеномного НИПС при оказании акушерско-гинекологической помощи. Проведена валидация ДНК-скрининга на образцах с известными результатами пренатальной инвазивной диагностики (N=1134). Доказана возможность транспортировки и хранения образцов (N=477). Проведено отсроченное исследование аликвот плазмы через год после первоначального исследования (N=70). Оценены факторы, которые могут влиять на результаты НИПС - доля плодовой ДНК, индекс массы тела (ИМТ), срок беременности, мозаицизм и другие.
Widely performed in Russia prenatally first-trimester screening is based on secondary markers of pathology and has limited sensitivity and specificity. The most promising alternative is the use of noninvasive prenatal screening for fetal aneuploidy (NIPS). This study aims to validate the possibility of NIPS usage for obstetric and gynecological care. DNA screening was validated on samples with known results of invasive prenatal diagnostics (N=1134). It was proven that it is possible to store and transport the samples (N=477). We studied plasma aliquot samples after one year of storage (N=70). Factors that can influence the NIPS results were also evaluated: the proportion of fetal DNA, body mass index (BMI), gestational age, mosaicism, and others.
Application of nipt by ngs sequencing in D.O. Ott research institute for obstetrics, gynaecology and reproductology
Authors: Козюлина П.Ю. , Вашукова Е.С. , Моршнева А.В. , Двойнова Н.М. , Тарасенко О.Е. , Талантова О.Е. , Коротеев А.Л. , Иванов Д.О. , Серебрякова Е.А. , Шабанова Е.С. , Пендина А.А. , Тихонов А.В. , Чиряева О.Г. , Ефимова О.А. , Иващенко Т.Э. , Баранов В.С. , Глотов А.С. 
Published: November 2020

Представлены результаты оригинальной технологии использования неинвазивного пренатального скрининга на основе полногеномного секвенирования внеклеточной ДНК (вкДНК) плода в материнской крови. Охарактеризованы основные параметры технологии и предложены новые возможности ее использования.
The results of the original technology of non-invasive prenatal screening based on genome-wide fetal DNA (cfDNA) sequencing of the fetus in maternal blood are presented. The main parameters of the technology are characterized and new possibilities for its use are proposed.
Siamese twin pregnancy in peritoneal dialysis : first case in the world
Authors: El Hamssili D , Bouattar T. , Bayahia R. , Benamar L. 
Published: November 2020

Introduction: The probability of conception is low in peritoneal dialysis (PD), and the probability of successful pregnancy is even lower. Nearly 60 years after the first reported case of successful pregnancy in a dialysis patient, many questions about pregnancy during dialysis remain unresolved, namely the required dialysis dose, the follow-up rhythm, the choice of the the most appropriate dialysis technique.
Case report: We report the first case worldwide of twin Siamese pregnancy in a patient on continuous ambulatory peritoneal dialysis (CAPD). The pregnancy was diagnosed at 7 weeks of amenorrhea (WA). The patient was initially under 2 exchanges per day, with 2-liter bags of Dianealof 1.36% glucose. As soon as the pregnancy was discovered, the prescription was modified, putting the patient under 3 exchanges a day with the same concentrates. The infusion volume was maintained at 2 liters up to 18 WA , and then reduced to 1.5 liters due to patient discomfort and abdominal hyperpressure. Daily ultrafiltration ranged from 180 to 800 ml with 1 liter diuresis. The blood pressure was well controlled, with an average of 125/80 mmHg, without need of antihypertensive drugs. On a biological level, the Kt / V was 2.2, nPCR was 0.8, and the weekly clearance was 80 L / 1.73 m². The average hemoglobin was 11.5 g / dl under erythropoietin 9000 units per week. At 20 WA, obstetrical ultrasound revealed a mono-chorionic, mono-amniotic twin pregnancy. Due to high maternal and fetal risks, closer obstetrical control was indicated. At 24 WA, morphological obstetrical ultrasound coupled with Doppler examination of the uterine and umbilical arteries favored the diagnosis of mono-amniotic mono-chorionic twin pregnancy with strong suspicion of Siamese contiguous to the pelvis, with a cerebral malformation in one of the fetuses. The patient experienced intense contractions and pelvic pain leading to an emergency cesarean section with two surviving Siamese twins, contiguous to the pelvis, weighing 900g, but who died one day after delivery.
Conclusion: Pregnancy during dialysis is at high maternal and fetal risks. It is necessary to prepare and follow this pregnancy to optimize the chances of success. This implies an adaptation of the medical treatment and dialysis prescription, including the volume and modality of exchanges. The same holds true for gynecological and obstetrical follow-up, which must be regular and strict, in order to prevent any maternal-fetal complications.
Les pièges des bilans de qualité de dialyse et nutrition en dialyse péritonéale
Authors: Padernoz-Lavallée Marie-Christine , Veniez Ghislaine 
Published: November 2020

Le RDPLF met à la disposition de ses membres différents modules de suivi et d’évaluation du traitement par DP. Le « Module nutrition et Dialyse Adéquate » est l’un des plus utilisés. Les résultats de ce module sont criblés, vérifiés, avant d’être enregistrés dans la base de données statistique du Registre. Nous présentons les principaux problèmes rencontrés lors des contrôles de qualité des données.
English abstract
The RDPLF makes available to its members different modules for monitoring and evaluating treatment by PD. The Nutrition and adequacy module is one of the most used. The results of this module are screened and verified before being recorded in the registry database. We present the main problems encountered during the data quality controls.
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