bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying opportunities to strengthen school food environments in the Pacific: a case study in Samoa
Authors: Reeve Erica , Thow Anne-Marie , Bell Colin , Soti-Ulberg Christina 
Published: October 2019

Abstract
Background Despite global recommendations to prioritise policies that create healthy environments within education institutions, the implementation of effective healthy school food policies has proved challenging for many countries. This study examined the experience of Samoa in introducing a stronger policy to improve the healthiness of school food environments. Our aim was to identify opportunities to strengthen school food policy implementation in Samoa and other comparable contexts.Methods We used a qualitative case study approach, underpinned by policy science theory. We conducted in-depth semi-structured interviews with 30 informants, coupled with analysis of relevant documents, to generate a detailed understanding of the relevant policy implementation processes in Samoa, and the perspectives and capacities of key implementation actors. Data collection and analysis were guided by the Health Policy Analysis Triangle supplemented by other policy theories relevant to policy process.Results Samoa’s school food policy operationalizes international ‘best practice’ recommendations for school food policy, and provides insights into the outcomes resulting from high level political commitment. We found health policymakers and leaders in Samoa to be strongly committed to improving school food environments. Despite this, compliance to the school food policy had continued to face challenges. Key issues that negatively impacted on the policy’s effectiveness were the broader food environment in which schools were surrounded by unhealthy options, the lack of priority by stakeholders outside of health, and the high degree of agency exercised by actors in and around the school. We noted several opportunities for policies to be effectively implemented and sustained. Respondents identified community level leaders as potentially pivotal stakeholders, particularly in a context where school governance draws heavily on community representation.Conclusions The re-engagement of political and community leaders to identify the institutional and operational changes required, including a fully-enforceable accountability mechanism, may be needed to improve and embed effectiveness.
Meta-analysis reveals severe pollination limitation for the flowering plants growing in East Himalaya-Hengduan Mountains region.
Authors: Jiang Xianfeng , Xie Yanping 
Published: October 2019

Abstract
Pollination limitation widely occurs and has an important effect on flowering plants. East Himalaya-Hengduan Mountains region is one of the 24 biodiversity hot spots around the world. However, no study as we known has synthetically assessed the degree of pollination limitation in this area. The present study aims to reveal the degree of pollination limitation for the flowering plants growing on East Himalaya-Hengduan mountains, and test if the reproductive features, the floral traits or the elevation are closely correlated with the degree of pollination limitation. We complied data from 76 studies, with 96 species and 108 independent data records included. We found that flowering plants in this area undergo severe pollination limitation (overall hedges’d=2.004, with the 95% confident interval [1.3264, 2.6743]), which is much higher than the flowering plants growing in many other regions around the world. The degree of pollination limitation was tested to be related to the capacity of autonomous self-reproduction and the pollination pattern (generalized vs. specialized pollinated) of plants. In addition, we found a clear relationship between elevation and the degree of pollination limitation, which indicates that plants might undergo severe pollination limitation in higher places.
Patterns of Failure in triple negative breast cancer patients in an urban, predominately black population
Authors: Cherng Hua-Ren , Rice Stephanie R , Hamza Muhammad , Murali Shruti , Rosenblatt Paula , Tkaczuk Katherine H R , Bellavance Emily , Cheston Sally , Amin Neha , Nichols Elizabeth 
Published: October 2019

Abstract
Background: We sought to evaluate the comprehensive patterns of failure associated with treatment for triple negative breast cancer (TNBC) at a single urban institution.
Methods: A retrospective review of TNBC patients treated from 2005-2015 was conducted. Detailed patient, tumor and treatment characteristics were included. Information on patterns of treatment failure, including local, regional, distant and combinations of these three were collected. Chi-square testing was used to compare variables, while logistic regression with Kaplan-Meier estimate was used to calculate overall survival (OS) and freedom from recurrence (FFR).
Results: With a median follow-up of 46 months, 32 (16%) documented failures occurred. Locoregional failures comprised 84% of failure patterns whether isolated or in combination with distant failure. 5-year OS and FFR were 76.4% and 83.8%, respectively. On univariate analysis, treatment failure was associated with insurance type, smoking status, presence of LVSI, clinical detection of tumor, increasing clinical tumor size (>2 cm), and increasing pathologic tumor stage, nodal stage, and overall staging. On multivariate analysis, pathologic nodal staging was the most significant predictor of treatment failure.
Conclusion: Our work shows that with modern therapies, treatment outcomes for patients with TNBC are very good. 53% of patients failed in distant and locoregional sites simultaneously, with an additional 34% failing locally only. These results highlight the need for aggressive local therapies in high-risk patients as well as suggest a need for improved follow up care focusing on detecting locoregional failures. Integrated multidisciplinary care is essential in the management of these patients at time of failure.
Keywords: Triple negative, breast cancer, failure, patterns, predictors
Bom Surabaya 2018: Terorisme dan Kekerasan Atas Nama Agama
Authors: Tamawiwy August Corneles 
Published: October 2019

The socio-political analysis of the acts of terrorism has produced phrases such as “terrorism/terrorist has no religion”. Such expressions overlook ethical-theological approaches in analyzing the acts of terrorism. This article aims to show that without an ethical-theological analysis, the socio-political interpretation of acts of terrorism is inadequate because of very strong theological elements that influence the person or group of people committing such acts of terror. Studying the case of the Surabaya Bombing in May 2018, this articledemonstrates that socio-political ideology is not strong enough to make a person or group of people to carry out acts of terrorism unless they are based on theologically informed belief.
Etika Animalitas
Authors: Borrong Robert Patannang 
Published: October 2019

Why animal ethics? The importance of animal ethics for the Indonesian public is to respond to the extinction threat of some animal species in Indonesia, like Tiger in Sumatera, Orang Utan in Kalimantan, Anoa in Sulawesi, and Cendrawasih in Papua. The way humans consume animals is often cruel, causing pain and suffering on the part of the animals. Such an attitude indicates the lack of moral standing in animal sphere. Philosophically and theologically, animal has sentience and intrinsic values which with humans have to recognise as the moral standard for animal.Using the theological-ethical concept that human being was created in the image of God, which means that they are not only endowed with senses but also the intellect to make them moral standing creature, this article points to the capacity as well as responsibility of humans to the environment, specifically to the animal world (animalities). As such, animals have to be regarded as having moral standing in the context of human beings’moral attitude and treat. Animals have to be respected and loved morally because they have sense, sentience and intrinsic value. Animals have feeling of pleasure and suffering which with human beings must honor and make as a moral standard. Like human beings, animals have the right to enjoy contentment and to be protected as the good creatures created by God. Although consuming animals can be considered part of natural order and natural recycle, animals have the right to enjoy liberation and prosperity during they are living, and to be avoided from suffering. In this sense, life and death must be accepted in balance. As a conclusion, in relating to animals, humans should demonstrate the virtues of respect, love, justice, and restrained attitudes. Animal ethics, thus, concerns with the sustainability of the peace and welfare of the whole creation on the planet earth.
Paulus dalam Konflik Antarumat Beragama: Membaca Konflik di Maluku Utara Berdasarkan Sikap Nasionalisme Paulus
Authors: Nataniel Demianus 
Published: October 2019

The imagination reflected in this article is what if Paul as a nationalist Jew living in the Roman imperium milieu became part of the North Maluku people in the late twentieth century. What would he likely have done when recognizing that there were signs that the conflict involving Muslims and Christians tended to develop into a religious war? Based on the discourses among scholars in the New Perspectives on Paul, arguing that Paul’sletters were part of his rhethoric againts his opponents including Roman imperialism, this article shows that as an educated leader, he was trying hard to prevent a religious war form occuring. Such an imagining is helpful for reflecting on the context of post-conflict North Maluku, where, as Christopher Duncan assumes, there has never been a truly reconciliation.
Shadow effect compensation method for ultrasonic transducer array model
Authors: Yang Yingpeng , Chen Xiao 
Published: October 2019

Although ultrasonic wind meter is widely used in wind speed measurement, the disadvantages of the ultrasonic wind meter structure by its measurement way still exist. The ultrasonic probe will stop on the way of the wind, which in turn produces a shadow area at the back of the probe, probe produce turbulence ahead. Therefore, it will result in error during the process of our normal wind speed measurement. At present, the ultrasonic wind speed Angle compensation formula is deduced by using the wind speed compensation formula on the path. The measurement data and the compensation formula are used for fitting comparison. It is observed that the Angle compensation function of wind and ultrasonic path fits well with the measured data, and the wind speed error after compensation is reduced from 14.65 % to 1.74 %. The modified measurement of accuracy of wind speed and direction can be used in two-dimensional ultrasonic orthogonal wind array model.
Investigation and optimization of the cable force of a combined highway and railway steel truss cable-stayed bridge in completion state
Authors: Li Haohong , Liu Shuyang , Shan Qiuwei , Zhang Liangliang , Wu Bo 
Published: October 2019

In order to study the reasonable cable force of a highway and rail dual-purpose steel truss cable-stayed bridge in the completion state, this paper employs four methods, i.e. the rigid supported continuous beam method, bending minimum energy method, influence matrix method and BP neural network method combined with a genetic algorithm. The Baijusi Yangtze river bridge, with a main span of 660 m in the completion state, is chosen as the object of study. Through comparative analysis, it is found that the rigid supported continuous beam combined with the influence matrix method can determine the reasonable cable force of the highway and rail dual-purpose steel truss cable-stayed bridge more quickly and effectively.
Core-Shell Molecularly Imprinted Polymer Nanocomposites for Biomedical and Environmental Applications
Authors: Shah Nasrullah , Gul Saba , Mazhar Ul-Islam  
Published: October 2019

:
Core-shell polymers represent a class of composite particles comprising of minimum two dissimilar
constituents, one at the center known as a core which is occupied by the other called shell. Core-shell molecularly
imprinting polymers (CSMIPs) are composites prepared via printing a template molecule (analyte) in the coreshell
assembly followed by their elimination to provide the everlasting cavities specific to the template molecules.
Various other types of CSMIPs with a partial shell, hollow-core and empty-shell are also prepared. Numerous
methods have been reported for synthesizing the CSMIPs. CSMIPs composites could develop the ability to identify
template molecules, increase the relative adsorption selectivity and offer higher adsorption capacity. Keen
features are measured that permits these polymers to be utilized in numerous applications. It has been developed
as a modern technique with the probability for an extensive range of uses in selective adsorption, biomedical
fields, food processing, environmental applications, in utilizing the plant's extracts for further applications, and
sensors. This review covers the approaches of developing the CSMIPs synthetic schemes, and their application
with special emphasis on uses in the biomedical field, food care subjects, plant extracts analysis and in environmental
studies.
Retraction Note: Low Doses of CPS49 and Flavopiridol Combination as Potential Treatment for Advanced Prostate Cancer
Authors: Zalazar Florencia , Luca Paola De , Gardner Kevin , Figg William D. , Meiss Roberto , Spallanzani Raúl G. , Vallecorsa Pablo , Elguero Belén , Cotignola Javier , Vazquez Elba , Siervi Adriana De 
Published: October 2019

:
Due to some inconsistencies in the figures provided by the first author that have come to light, and after a thorough investigation we would like to retract our paper: “Low doses of CPS49 and flavopiridol combination as potential treatment for advanced prostate cancer. By: Zalazar F, De Luca P, Gardner K, Figg WD, Meiss R, Spallanzani RG, Vallecorsa P, Elguero B,
Cotignola J, Vazquez E, De Siervi A. Curr. Pharm. Biotechnol., 2015, 16(6), 553-63.

:
Submission of a manuscript to the respective journals implies that all authors have read and agreed to the content of the
Copyright Letter or the Terms and Conditions. As such this article represents a severe abuse of the scientific publishing system.
Bentham Science Publishers takes a very strong view on this matter and apologizes to the readers of the journal for any
inconvenience this may cause.
Multi-Targeted Design and Development of Dihydroisoquinolines as Potent Antimalarials
Authors: Mule Raviraj V. , Rochlani Sneha P. , Choudhari Prafulla B. , Dhavale Rakesh P. , Bhatia Manish S. 
Published: October 2019

Background:
Malaria is a serious parasitic infection with greater morbidity and motility
in recent decades. Cysteine protease and DHODH enzyme serve as a potential target for antimalarial
agents which inhibit parasite multiplication in the erythrocyte stage. Development of new leads
which specifically target cysteine protease and DHODH enzyme can reduce the side effects and
overcome multidrug resistance.

Objectives:
Representing the design and development of antimalarial agents by targeting cysteine
protease and DHODH (Dihydroorotate dehydrogenase) enzyme by structure-based drug design.

Methods:
In present work, the rational development of antimalarial agents by targeting cysteine
protease and DHODH has been made by integrating binding confirmation from virtual analysis and
synthetic procedures.

Result:
A novel series of dihydroisoquinolines was designed by structure-based drug design.
Compounds from the dataset were screened for interaction at the target site by performing molecular
docking study and subsequently, all molecules were screened for drug-like properties and toxicity,
prior to synthesis molecules subjected to virtual filters. Designed molecules which exceed these
virtual filters were synthesized, characterized and finally screened for antimalarial activity.

Conclusion:
In this work, it has been observed that compound A1, A5, A6 and A9 showed desirable
biological activity towards targets and also specific hydrogen bonding interaction with the targets.
Further optimization in leads yields a drug-like candidate and may overcome multidrug resistance.
Development of 'S', 'N' Heterocycles as Antimycobacterials Targeting Fatty Acid Biosynthesis
Authors: Dahiwade Lalita K. , Rochlani Sneha P. , Choudhari Prafulla B. , Dhavale Rakesh P. , More Harinath N. 
Published: October 2019

Background:
Mycobacterium tuberculosis is a causative organism of tuberculosis,
which is the most deadly disease after cancer in the current decade. The development of multidrug
and broadly drug- resistant strains makes the tuberculosis problem more and more critical. In the last
40 years, only one molecule is added to the treatment regimen. Generally, drug design and development
programs are targeted proteins whose function is known to be essential to the bacterial cell.

Objectives:
Here are the development of 'S', 'N’ heterocycles as antimycobacterials targeting fatty
acid biosynthesis are reported.

Material and Methods:
In the present communication, rational development of anti-mycobacterial
agent's targeting fatty acid biosynthesis has been done by integrating the pocket modeling and virtual
analysis.

Results:
The identified potential 33 lead compounds were synthesized, characterized by physicochemical
and spectroscopic methods like IR, NMR spectroscopy and further screened for antimycobacterial
activity using isoniazid as standard. All the designed compounds have shown profound
antimycobacterial activity.

Conclusion:
In this present communication, we found that 3c, 3f, 3l and 4k molecules had expressive
desirable biological activity and specific interactions with fatty acids. Further optimization of
these leads is necessary for the development of potential antimycobacterial drug candidates having
fewer side effects.
Epigenetics, Maternal Diet and Metabolic Programming
Authors: Ramírez-Alarcón Karina , Sánchez-Agurto Ángela , Lamperti Liliana , Martorell Miquel 
Published: October 2019

Background:
The maternal environment influences embryonic and fetal life. Nutritional deficits or excesses alter the trajectory of fetus/offspring’s development. The concept of “developmental programming” and “developmental origins of health and disease” consists of the idea that maternal diet may remodel the genome and lead to epigenetic changes. These changes are induced during early life, permanently altering the phenotype in the posterior adult stage, favoring the development of metabolic diseases such as obesity, dyslipidemia, hypertension, hyperinsulinemia, and metabolic syndrome. In this review, it is aimed to overview epigenetics, maternal diet and metabolic programming factors and determine which of these might affect future generations.

Scope and Approach:
Nutrients interfere with the epigenome by influencing the supply and use of methyl groups through DNA transmethylation and demethylation mechanisms. They also influence the remodeling of chromatin and arginine or lysine residues at the N-terminal tails of histone, thus altering miRNA expression. Fats, proteins, B vitamins and folates act as important cofactors in methylation processes. The metabolism of carbon in the methyl groups of choline, folic acid and methionine to S-Adenosyl Methionine (SAM), acts as methyl donors to methyl DNA, RNA, and proteins. B-complex vitamins are important since they act as coenzymes during this process.

Key Findings and Conclusion:
Nutrients, during pregnancy, potentially influence susceptibility to diseases in adulthood. Additionally, the deficit or excess of nutrients alter the epigenetic machinery, affecting genes and influencing the genome of the offspring and therefore, predisposing the development of chronic diseases in adults.
Exopolysaccharide Produced from Rhizobium spp. - An Interesting Product for Industry and Environment
Authors: Castellane Tereza Cristina Luque , de Sousa Bruna Fernanda Silva , Lemos Eliana Gertrudes de Macedo 
Published: October 2019

:
Most legume species, such as soybeans, beans, and clover, have the ability to establish a
symbiotic relationship with nitrogen-fixing bacteria in the soil, which promotes plant growth and
productivity. Exopolysaccharide macromolecules are particularly necessary for binding the bacteria
to root hairs and initiating the deformation of root hairs, thus trapping the bacteria to initiate root invasion
through a tube-like infection thread. Very few studies have focused on the isolation and characterization
of new rhizobial exopolysaccharides, despite their unique and specific biological and
physicochemical properties. However, rhizobial exopolysaccharides may be studied in detail in the
near future, for the development of suitable substitutes for xanthan gum. This review discusses some
analytical strategies for characterization of rhizobial exopolysaccharide, the relation between their
structure and properties, and a novel application of rhizobial exopolysaccharides. The potential application
of exopolysaccharides and living cells as biosorbents has also been reviewed.
Total Hip Arthroplasty in Patient with Melorheostosis (Case Report)
Authors: Kuzin V. V. , Egiazaryan K. A. , Raksha A. P. , Ratyev A. P. , Kuzin A. V. , Zhavoronkov E. A. , Chebotarev V. V. 
Published: October 2019

Melorheostosis is a rare mesenchymal dysplasia of bone manifesting as regions of sclerosing and thickening of bone tissue. This disease may involve the adjacent soft tissues and lead to joint pain, limitation of joint motion, stiffness resulting from abnormal ossification and soft-tissue contractures due to periarticular fibrosis. The paper describes a clinical case of a patient who presented with pain and stiffness in the proximal part of the left hip which patient suffered for the last 10 years. At first the patient had intermittent pain in the lower back and left hip during and after walking. Radiographs revealed dense sclerotic and wavy cortex and hyperostosis involving the left iliac crest, the acetabulum, and the femur. CT angiography with contrast was performed for preoperative planning. During the procedure the authors performed total hip arthroplasty of the left hip with excision of fibro-ossifications in the left ilioinguinal area. Severe periarticular fibrosis of the soft tissue was observed intraoperatively and cartilage-like formation was visible around the joint. A sample of the ossification bone was resected for histologic confirmation of the diagnosis; extensive cortical sclerosis with varying thickness typical of melorheostosis was found. Early postoperative period went without complications following routine post-THR protocol. Postoperative X-rays at 6, 12, 24 months did not reveal any complications or new ossifications. Full ROM and pain-free function were achieved in the left hip and lower back of the patient. The present clinical case of total hip arthroplasty with excision of fibroossifications provided good clinical outcome for melorheostosis of the left hip.