bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic Impact of Improving Patient Safety Using Sugammadex for Routine Reversal of Neuromuscular Blockade in Spain
Authors: Martinez-Ubieto Javier , Aragón-Benedí Cristian , de Pedro José María , Cea Luis , Baladron Alberto Morell , Jiang Yiling , Cedillo Sergio , Ramírez-Boix Paula , Pascual-Bellosta Ana 
Published: July 2020

Abstract
Background
Neuromuscular blocking (NMB) agents are often administered to facilitate tracheal intubation and prevent patient movement during surgical procedures requiring the use of general anesthetics. Incomplete reversal of NMB, can lead to residual NMB, which can increase the risk of post-operative pulmonary complications. Sugammadex is indicated to reverse neuromuscular blockade induced by rocuronium or vecuronium in adults. The aim of this study is to estimate the clinical and economic impact of introducing sugammadex to routine reversal of neuromuscular blockade (NMB) with rocuronium in Spain.
Methods
A decision analytic model was constructed reflecting a set of procedures using rocuronium that resulted in moderate or deep NMB at the end of the procedure. Two scenarios were considered for 537,931 procedures using NMB agents in Spain in 2015: a scenario without sugammadex versus a scenario with sugammadex. Comparators included neostigmine (plus glycopyrrolate) and no reversal agent. The total costs for the healthcare system were estimated from the net of costs of reversal agents and overall cost offsets via reduction in postoperative pneumonias and atelectasis for which incidence rates were based on a Spanish real-world evidence (RWE) study. The model time horizon was assumed to be one year. Costs were expressed in 2019 euros (€) and estimated from the perspective of a healthcare system. One-way sensitivity analysis was carried out by varying each parameter included in the model within a range of +/-50%.
Results
The estimated budget impact of the introduction of sugammadex to the routine reversal of neuromuscular blockade in Spanish hospitals was a net saving of €57.1 million annually. An increase in drug acquisition costs was offset by savings in post-operative pulmonary events, including 4,806 post-operative pneumonias and 13,996 cases of atelectasis. The total cost of complications avoided was €70.4 million. All parameters included in the model were tested in sensitivity analysis and were favorable to the scenario with sugammadex.
Conclusions
This economic analysis shows that sugammadex can potentially lead to cost savings for the reversal of rocuronium-induced moderate or profound NMB compared to no reversal or reversal with neostigmine in the Spanish health care setting.
Regulating interfacial chemistry in lithium-ion batteries by a weakly-solvating electrolyte
Authors: Yao Yu-Xing , Chen Xiang , Yan Chong , Zhang Xue-Qiang , Cai Wen-Long , Huang Jia-Qi , Zhang Qiang 
Published: July 2020

Abstract
The performance of lithium-ion battery is highly dependent on its interfacial chemistry, which is regulated by electrolytes. Conventional electrolyte typically contains polar solvents to dissociate Li salts. Here, we report a novel weakly-solvating electrolyte (WSE) that consists of a pure non-polar solvent, which leads to a peculiar solvation structure where ion pairs and aggregates prevail under a low salt concentration of 1.0 M. Importantly, WSE forms unique anion-derived interphases on graphite electrodes that exhibit fast-charging and long-term cycling characteristics. First-principles calculations unravel a general principle that the competitive coordination between anions and solvents to Li ion is the origin of different interfacial chemistries. By bridging the gap between solution thermodynamics and interfacial chemistry in batteries, this work opens a brand-new way towards precise electrolyte engineering for energy storage devices with desired properties.
Flexible and efficient perovskite quantum dot solar cells via hybrid interfacial architecture
Authors: Hu Long , Zhao Qian , Huang Shujuan , Zheng Jianghui , Guan Xinwei , Patterson Robert , Kim Jijun , Shi Lei , Qi Lei , Lin Chun-Ho , Chu Dewei , Wan Tao , Cheong Soshan , Tilley Richard , Ho-Baillie Anita , Luther Joseph , Yuan Jianyu , Wu Tom 
Published: July 2020

Abstract
All-inorganic CsPbI3 perovskite quantum dots (QDs) have received intense research interest for photovoltaic applications because of the recently demonstrated higher power conversion efficiency compared to solar cells using other QD materials. These QD devices also exhibit good mechanical stability amongst various thin-film photovoltaic technologies. In this work, through developing a hybrid interfacial architecture consisting of CsPbI3 QD/PCBM heterojunctions, we report the formation of an energy cascade for efficient charge transfer at both QD heterointerfaces and QD/electron transport layer interfaces. The champion CsPbI3 QD solar cell has a best power conversion efficiency of 15.1%, which is among the highest report to date. Building on this strategy, we demonstrate the very first perovskite QD flexible solar cell with a record efficiency of 12.3%. A detailed morphological characterization reveals that the perovskite QD film can better retain structure integrity than perovskite bulk thin-film under external mechanical stress. This work is the first to demonstrate higher mechanical endurance of QD film compared to bulk thin-film, and highlights the importance of further research on high‐performance and flexible optoelectronic devices using solution-processed QDs.
Runx2 deficiency in osteoblasts promotes myeloma resistance to bortezomib by increasing thrombospondin 1-mediated TGF-ß1 activation and suppression immunity in the bone marrow
Authors: Zhang Chao , Xu Xiaoxuan , Trotter Timothy N. , Gowda Pramod S. , Lu Yun , Suto Mark J. , Javed Amjad , Murphy-Ullrich Joanne E. , Li Juan , Yang Yang 
Published: July 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
High-dose versus low-dose ergocalciferol for correcting hypovitaminosis D after fragility hip fracture: A randomized controlled trial
Authors: Jarusriwanna Atthakorn , Phusunti Suchat , Chotiyarnwong Pojchong , Unnanuntana Aasis 
Published: July 2020

Abstract
Background: Hypovitaminosis D can be observed in most fragility hip fracture patients. However, measurement of 25-hydroxyvitamin D [25(OH)D] level is costly and may not be available in some centers. Without the baseline 25(OH)D level, the appropriate dose of vitamin D supplementation is not known. The aim of this study was to evaluate the effectiveness and safety of vitamin D supplementation in fragility hip fracture patients compared between high- and low-dose vitamin D supplementation. Methods: A total of 140 patients diagnosed with fragility hip fracture were randomly allocated to either the high-dose (60,000 IU/week) or low-dose (20,000 IU/week) vitamin D2 supplementation group for 12 weeks. The number of patients who achieved sufficient vitamin D level [25(OH)D level > 30 ng/mL], the proportion of patients who developed hypercalcemia, and the functional outcome were compared between groups. Results: Of the 140 patients who were enrolled, 21 patients were lost to follow-up during the study period. The remaining 119 patients (58 and 61 in the high- and low-dose group, respectively) were included in the final analysis. The high-dose group had a higher rate of serum 25(OH)D restoration to sufficient level than the low-dose group (82.8% vs 52.5%, respectively). Approximately 3.4% and 1.6% of patients in the high- and low-dose groups, respectively, had mild hypercalcemia, but none developed moderate, severe, or symptomatic hypercalcemia. There were no differences in functional outcome scores between groups.Conclusions: In treatment settings where baseline serum 25(OH)D level can’t be evaluated, we recommend high-dose vitamin D2 of approximately 60,000 IU/week for 12 weeks, with subsequent switch to a maintenance dose. This regimen effectively restored serum vitamin D to a sufficient level in 82.8% of patients without causing symptomatic hypercalcemia.Trial registration: The protocol of this study was retrospectively registered in the Thai Clinical Trials Registry database no. TCTR20180302007 on 20 February 2018.
Awareness of Coronavirus Disease From Conception to Delivery: Antenatal Mental Journey Breaking Anxiety During Outbreak
Authors: Palalioglu Rabia Merve Erbiyik , Karadeniz Ozan , Aytok Gokce Ipek , Palalioglu Batuhan , Koyan Gizem Nur , Erbiyik Halil Ibrahim , Muhcu Murat 
Published: July 2020

Abstract
Purpose
The objective of this study was to evaluate the psychological impact of the coronavirus disease on women sensitized by pregnancy after the first case was confirmed in Turkey, which has been declared a pandemic by the World Health Organization. This study also intends to help developing preventive measures for pregnants, reducing infection incidence, developing solutions to protect public health, and establishing whether pregnants have sufficient knowledge and awareness to manage this situation.
Methods
This prospective study was conducted at two centers. A total of 529 pregnant women from all three trimesters were given questionnaires that consisted of 51 original questions.
Results
The period when anxiety was highest was the 2nd trimester, whereas women in the 1st trimester had the lowest level of anxiety. High levels of awareness were observed in patients with heart disease, but patients with diabetes mellitus had a high level of anxiety. There was a statistically significant correlation between anxiety and awareness scores of the coronavirus disease.
Conclusion
The treatment and the long-term effects of the coronavirus disease remain unknown. It is important to maintain the mental and physical health of pregnants, who are in a more delicate condition in the society.
Neurological and Clinical Outcomes After In-Hospital Cardiac Arrest Following a New Legislation on Life-Sustaining Treatments
Authors: Jeon Sang-beom , Lee Hyunjo , Park Bobin , Choi Soh Hyun , Hong Yoon-Hee , Kim Won Young , Hong Sang-Bum , Kim Young-Hak 
Published: July 2020

Abstract
Background: The precise neurological profiles after in-hospital cardiac arrest (IHCA) are yet to be elucidated. We aimed to evaluate the neurological profiles of patients with IHCA from early time to long-term follow-up and the changes in their neurological outcomes after implementing legislation on the cessation of life-sustaining treatments.Methods: A national legislation allowing the withdrawal of life-sustaining treatments was implemented in South Korea on February 4, 2018. For this prospective cohort study, we established a neurological rapid response team on March 21, 2017, and serially evaluated the neurological status of patients with IHCA from the initial resuscitation to 12 months after the onset of IHCA. The primary outcome was good neurological status defined as a Clinical Performance Category score (range from 1 to 5, with higher scores indicating greater disability) of 1−2 at 12 months after IHCA. The secondary outcomes were the awakening and neurological recovery during the first week and the survival at 12 months. The outcomes were also compared between before and after the implementation of the legislation.Results: Of 291 adult patients with IHCA, 144 were included in the Before Period, and 147 were included in the After Period. Physician Orders for Life-Sustaining Treatments were made in 63 (42.9%) patients in the After Period. On the first day and during the first week after IHCA, the awakening was achieved in 21.0% and 40.9%, respectively, and neurological recovery in 4.1% and 15.8%, respectively. The proportion of patients with good neurological status at 12 months was not significantly different between the Before Period (19.0%) and the After Period (15.1%; p = 0.37). Awakening (40.0% vs. 42.2%; p = 0.65) and neurological recovery (16.7% vs. 15.0%; p = 0 .69) during the first week as well as survival at 12 months (25.0% vs. 18.4%; p = 0.17) also did not show significant differences between the two periods. Conclusion: Awakening and neurological recovery were remarkable throughout the first week. In the current study, implementating the legislation allowing the cessation of life-sustaining treatments did not significantly affect the neurological and survival outcomes after IHCA. Trial registration: This study was registered in clinical-trial.gov (NCT03006484) in December 2016.
Bayesian Learning of Chemisorption for Bridging Complexities of Electronic Descriptors
Authors: Wang Siwen , Pillai Hemanth , Xin Hongliang 
Published: July 2020

Abstract
Building upon the d-band reactivity theory in surface chemistry and catalysis, we develop a Bayesian learning approach to probing chemisorption processes at atomically tailored metal sites. With representative species, e.g., *O and *OH, the Bayesian model trained with ab initio adsorption properties of transition metals predicts site reactivity at a diverse range of intermetallics and near-surface alloys while naturally providing uncertainty quantification from posterior sampling. More importantly, this conceptual framework sheds light on the orbitalwise nature of chemical bonding at adsorption sites with d-states characteristics ranging from bulk-like semi-elliptic bands to free-atom-like discrete energy levels, bridging complexities of electronic descriptors for the prediction of novel catalytic materials.
Force Generation of the Hallux is More Sensitive to the Ankle and Metatarsophalangeal Joint Angle Than the Lesser Toes
Authors: Saeki Junya , Iwanuma Soichiro , Torii Suguru 
Published: July 2020

Abstract
Background: Because the structure of the hallux is independent of that of the lesser toes and it uses different muscles to move, the force generation characteristics of the hallux could be independent of those of the lesser toes. The purpose of this study is to clarify the torque–angle relationships in the first and second–fifth metatarsophalangeal joints (MTPJs).Methods: Ten healthy young men served as volunteers in this study. The maximal voluntary contraction (MVC) of the plantar-ﬂexion torques of the first and second–fifth MTPJs were measured at 0°, 15°, 30°, and 45° dorsiflexed positions of the MTPJs and 20° plantar-flexed, neutral, and 20° dorsiflexed positions of the ankle. The Friedman test and the Wilcoxon signed-rank test with a Holm correction was used for the ankle and MTPJ angles.Results: When the first MTPJ was 0° to DF30°, the MVC torque of the first MTPJ at DF20° of the ankle was higher than at PF20°of the ankle. On the other hand, no significant difference existed between the MVC torques of the second–fifth MTPJs at any ankle position. When the ankle was in a neutral position, the MVC of the first MTPJ torque increased as the MTPJ was dorsiflexed. However, the MVC torques of the second through fifth MTPJs did not significantly differ for the 15°, 30°, and 45° dorsiflexed positions of the MTPJ.Conclusion: The MVC torque of the first MTPJ is more sensitive to the MTPJ and ankle positions than the second–fifth MTPJs.
Efficacy and safety of tocilizumab in COVID-19 patients: A Meta-Analysis
Authors: Liu Li-Peng , Zong Su-Yu , Li Jun , Zhang Ao-Li , Liu Chao , Guo Ye , Yang Wen-Yu , Chen Xiao-Juan , Zhang Ying-Chi , Zhu Xiao-Fan 
Published: July 2020

Abstract
The therapeutic effect of tocilizumab remains controversial. We aimed to evaluate whether tocilizumab might be beneficial in COVID-19 patients. We searched PubMed, Embase and Cochrane library from inception to June 23, 2020. Summary estimates of overall response rate (ORR) and all-cause death rate in all patients were analyzed. This study was registered with PROSPERO (CRD42020191313). We included data from 28 articles including 991 COVID-19 patients who underwent tocilizumab administration. The pooled ORR was 72% (95% CI, 66-79%) and pooled all-cause death rate was 16% (95% CI, 11-22%). The optimal timing of administration was the 7.15 day from the symptom onset and with the lowest death rate of 13.11%. 562 patients were defined as with severe infection, and the pooled ORR was 78% (95% CI, 70-85%). The pooled ORR of 56 organ transplantation recipients was 53% (95% CI, 26-78%), which was lower than non-transplant patients [75% (95% CI, 69-81%)]. Nearly all studies confirmed the safety of tocilizumab administration. Tocilizumab improves the clinical outcome of COVID-19 patients, especially in severe cases, and the optimal timing of administration may provide the guidance for management. However, tocilizumab may be used with caution in solid transplant recipients for the suboptimal efficacy.
Expanding Enhanced Recovery Protocols for Cardiac Surgery to Include the Patient Voice: a Scoping Review Protocol
Authors: Oravec Nebojša , Arora Rakesh C. , Bjorklund Brian , Gregora April , Monnin Caroline , Duhamel Todd A. , Kent David E. , Schultz Annette S.H. , Chudyk Anna Maria 
Published: July 2020

Abstract
Background
Cardiac surgery is becoming increasingly common in older, more vulnerable adults. A focus on timely and complete medical and functional recovery has led to the development of enhanced recovery protocols (ERPs) for a number of surgical procedures and subspecialties, including cardiac surgery (ERAS® Cardiac). An element that is often overlooked in the development and implementation of ERPs is the involvement of key stakeholder groups, including surgery patients and caregivers (e.g., family and/or friends). The aim of this study is to describe a protocol for a scoping review of cardiac patient and caregiver preferences and outcomes relevant to cardiac surgery ERPs.
Methods
Using Arskey and O’Malley’s six-stage framework for scoping review methodologies with adaptions from Levac et al., a scoping review of existing literature describing patient- and caregiver-identified preferences and outcomes as they relate to care received in the perioperative period of cardiac surgery will be undertaken. The search for relevant articles will be conducted using electronic databases (i.e., the Cochrane Library, Medline, PsycINFO, Scopus, and Embase), as well as through a search of the grey literature (e.g., CPG Infobase, Heart and Stroke Foundation, ProQuest Theses and Dissertations, Google Advanced and Prospero). Published and unpublished full-text articles written in English, published after the year 2000, and that relate to the research question will be included. Central to the design of this scoping review is our collaboration with two patient partners who possess lived experience as cardiac surgery patients.
Discussion
This review will identify strategies that can be integrated into ERPs for cardiac surgery which align with patient- and caregiver-defined values. Broadly, it is our goal to demonstrate the added value of patient engagement in research to aid in the success of system change processes.
Clinical characteristics of neonates with coronavirus disease 2019 (COVID-19): a systematic review﻿
Authors: Hu Yuan , Xiong Jing , Shi Yuan 
Published: July 2020

Abstract
This study aimed to summarize the existing literature on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in newborns to clarify the clinical features and outcomes of neonates with COVID-19. A systematic search was performed in PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP databases from January 1, 2019 to April 30, 2020. The references of relevant studies were also searched. A descriptive summary was organized by aspects of clinical presentations (symptoms, laboratory examinations, and imaging) and outcomes. We identified 14 studies reporting 18 newborns with COVID-19. The most common clinical manifestations were fever (62.5%), shortness of breath (50.0%), diarrhea/vomiting/feeding intolerance(43.8%), cough (37.5%), dyspnea (25.0%), and nasal congestion/runny nose/sneeze(25.0%). Atypical symptoms included jaundice and convulsion. Lymphocyte numbers decreased in 5 cases, and radiographic findings were likely to show pneumonia. All newborns recovered and discharged from the hospital, and there was no death.Conclusion: Clinical symptoms of neonatal SARS-CoV-2 infection are atypical, most of them are mild. Up to now, the prognosis of newborns is good, and there is no death. Intrauterine vertical transmission is possible, but confirmed evidence is still lacking. The Long-term follow-up of potential influences of SARS-CoV-2 infection on neonates need further exploration.
ANÁLISE DE CAPACIDADE DO PROCESSO PRODUTIVO UTILIZANDO TÉCNICAS DE PROGRAMAÇÃO LINEAR
Authors: Moura Cassiano Rodrigues , Ulbricht Gerson , Krainski Elcio 
Published: July 2020

Empresas buscam aprimoramento de diversas formas a fim de manterem a competitividade no mercado. Busca-se sempre produzir mais no menor tempo possível, para isso faz-se necessário otimizar a execução de projetos e dos processos. Com este cenário, de elevada competição, as organizações têm buscado maneiras de aumentar sua qualidade e produtividade. Neste contexto este trabalho tem como objetivo avaliar a capacidade do processo produtivo em uma determinada empresa sob a ótica da Pesquisa Operacional, especificamente utilizando a técnica de Programação Linear que é considerada umas das ferramentas mais difundidas para estas tomadas de decisões. Pois, busca obter uma solução ótima para um dado problema. A metodologia de estudo utilizada se trata de um estudo de caso, na qual desejou-se analisar a programação linear como ferramenta para avaliação do setor produtivo, com isso busca-se identificar os principais produtos que são produzidos e em quais setores estes são processados. A partir destas informações é elaborado um modelo de programação linear com o objetivo de fazer a verificação dos setores procurando identificar possíveis gargalos produtivos. Após definido o modelo matemático, foi desenvolvida uma planilha para resolução, utilizando a ferramenta Solver, de modo que está possa ser alimentada com novos parâmetros sempre que necessário. Resultados mostraram que o modelo matemático se torna eficaz para a programação do cenário estudado bem como de novos cenários.
Flood damage and risk assessment for urban area in Malaysia
Authors: Romali Noor Suraya , Yusop Zulkifli 
Published: July 2020

Abstract
In recent years, flood risk map has been widely accepted as a tool for flood mitigation. The risk of flooding is normally illustrated in terms of its hazard (flood inundation maps), while vulnerability emphasizes the consequences of flooding. In developing countries, published studies on flood vulnerability assessment are limited, especially on flood damage. This paper attempts to establish a flood damage and risk assessment framework for Segamat town in Johor, Malaysia. A combination of flood hazard (flood characteristics), exposure (value of exposed elements), and vulnerability (flood damage function curve) were used for estimating the flood damage. The flood depth and areal extent were obtained from flood modeling and mapping using HEC-HMS/RAS and Arc GIS, respectively. Expected annual damage (EAD) for residential areas (50,112 units) and commercial areas (9,318 premises) were RM12.59 million and RM2.96 million, respectively. The flood hazard map shows that Bandar Seberang area (46,184 properties) was the most affected by the 2011 flood. The flood damage map illustrates similar patterns, with Bandar Seberang suffering the highest damage. The damage distribution maps are useful for reducing future flood damage by identifying properties with high flood risk.