bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investment in time preference and long-run distribution
Authors: Hayashi Takashi 
Published: April 2020

AbstractThis paper presents a simple dynamic general equilibrium model in which each household can make a costly investment in patience capital at each time. We show that the interior long-run steady state is unstable, in the sense that per household, there is a one-dimensional curve lying in the two-dimensional space of its patience capital and physical capital amounts, and convergence happens only when its initial pair falls exactly on the curve. Households with the initial vectors falling in the upper side of the curve invest more in patience capital, which leads themselves to save more, and hence, the consumption level grows in the long run. Households with the initial vectors falling in the lower side opt out from investing in patience capital, leading to a decay of patience level, which leads themselves to save less and hence they perish in the long run. We also show a possibility that there is an expanding swing between the two classes.
Linking supervisor developmental feedback to in-role performance: The role of job control and perceived rapport with supervisors
Authors: Zhang Zhenduo , Zhang Li , Wang Honglei , Zheng Junwei 
Published: April 2020

AbstractThis paper investigates the underlying mechanism and boundary condition of the relationship between day-level supervisor developmental feedback (SDF) and day-level in-role performance (IRP) based on the framework of social exchange theory. The current study collects 290 matched surveys nested in 58 Chinese employees for five consecutive days, employing experience sampling method. Using hierarchical linear regression analysis, this paper examines the mediating role of perceived rapport with supervisors (PRS) and the moderating role of job control. Results show SDF has a positive effect on PRS and consequently enhances employee IRP. This indirect effect is moderated by employee job control. When job control is high, SDF helps supervisors develop a high-quality rapport with employees and is conducive to employees improving their IRP. However, when job control is low, the positive effect of SDF on IRP through PRS is not significant.
Causal interaction and effect modification: same model, different concepts
Authors: Keele Luke , Stevenson Randolph T. 
Published: April 2020

AbstractSocial scientists use the concept of interactions to study effect dependency. In the causal inference literature, interaction terms may be used in two distinct type of analysis. The first type of analysis focuses on causal interactions, where the analyst is interested in whether two treatments have differing effects when both are administered. The second type of analysis focuses on effect modification, where the analyst investigates whether the effect of a single treatment varies across levels of a baseline covariate. While both forms of interaction analysis are typically conducted using the same type of statistical model, the identification assumptions for these two types of analysis are very different. In this paper, we clarify the difference between these two types of interaction analysis. We demonstrate that this distinction is mostly ignored in the political science literature. We conclude with a review of several applications where we show that the form of the interaction is critical to proper interpretation of empirical results.
Frequent use of selected sugary products associates with thinness, but not overweight during preadolescence: a cross-sectional study
Authors: Lommi Sohvi , Figueiredo Rejane Augusta de Oliveira , Tuorila Hely , Viljakainen Heli 
Published: April 2020

AbstractConvincing evidence suggests that diets laden with added sugar, specifically sugar-sweetened beverages, associate with excess weight in children. The relationships between sugar consumption frequency and BMI remain less well studied. We, therefore, evaluated children’s consumption frequency of selected sugary products (n8461; mean age 11·1 (sd0·9) years) selected from the Finnish Health in Teens cohort study. Using a sixteen-item FFQ including six sugary products (chocolate/sweets, biscuits/cookies, ice cream, sweet pastry, sugary juice drinks and sugary soft drinks), we calculated a Sweet Treat Index (STI) for the frequency of weekly sugary product consumption and categorised children based on quartiles (Q) into low (Q1, cut-off < 4·0), medium (Q2 + Q3, range 4·0–10·5) and high STI (Q4, cut-off > 10·5), and as thin, normal and overweight/obese based on the measured BMI. Through multinomial logistic regression analyses, we found that subjects with a high STI exhibited a higher risk of being thin (OR 1·20, 95 % CI 1·02, 1·41) and lower risk of being overweight (OR 0·79, 95 % CI 0·67, 0·92), while subjects with a low STI were at higher risk of being overweight (OR 1·32, 95 % CI 1·14, 1·53). High consumption frequencies of salty snacks, pizza and hamburgers most closely were associated with a high STI. Our findings suggest that consuming sugary products at a high frequency does not associate with being overweight. The relationship between a low consumption frequency and being overweight suggests that overweight children’s consumption frequency of sugary products may be controlled, restricted or underreported.
Geochemical and isotopic compositions of Late Permian metavolcano–sedimentary sequence in the southern Songpan–Ganzi Orogen, eastern Tibetan Plateau
Authors: Zhu Yudi , Dai Yanpei , Wang Lili , Xiu Di , Chen Chao 
Published: April 2020

AbstractThe Permian metavolcano–sedimentary sequence of the Jianglang and Taka domes in the southern Songpan–Ganzi Orogen is composed of bedded marble and sandwiched metabasalt. This study presents geochemistry, C–O–Nd isotope systematics and zircon U–Pb geochronology data to explore the formation mechanism and tectonic setting of its protolith. The marble samples have high δ13CV-PDB (4.0 ‰ to −0.1 ‰) and δ18OV-SMOW (16.3 ‰ to 13.6 ‰) values, with similar εNd(t) values (−5.3 to −7.2) to Late Permian conodonts. They display seawater-like features, e.g. superchondritic Y/Ho ratios, negative Ce and positive La, Gd and Y anomalies, indicating a marine carbonate protolith in oxygen-rich palaeoseawater. Their pronounced positive Eu anomalies suggest a contribution (5 % to 1 %) of submarine high-T hydrothermal fluids. The metabasalt samples show low SiO2, high Fe2O3T and MgO contents. They have low La/Sm, (Th/Ta)PM and (La/Nb)PM ratios, without correlations between MgO and other major/trace elements. These signatures could be attributed to insignificant fractional crystallization and crustal contamination. Their rare earth elements (REE) patterns, trace element profiles and trace element ratios are comparable to those of mid-ocean ridge basalt (MORB), suggesting a depleted MORB-type mantle reservoir. Melt modelling illustrates low degrees (<10 %) of partial melting in the spinel stability field at a depth of 30–60 km. Moreover, the metabasalt contains 2453.7–258.9 Ma detrital zircons significantly related to the Palaeoproterozoic crystalline basement, Rodinia supercontinent, Caledonian events and c. 260 Ma Emeishan large igneous province. Combined with previous studies, we advocate that the investigated metavolcano–sedimentary suquence was most likely formed during the Late Permian in a mature back-arc basin of the Palaeo-Tethys ocean.
Does REDD+ have a chance? Implications from Pemba, Tanzania
Authors: Andrews Jeffrey B. , Caro Tim , Juma Ali Said , Collins Amy C. , Bakari Hamadi Bidawa , Sellieman Khamis Hassan , Mzee Abdi , Sharif Ngwali Assaa , Borgerhoff Mulder Monique 
Published: April 2020

AbstractConservation scientists continue to debate the strengths and weaknesses of REDD+ as an instrument to slow greenhouse gas emissions in the developing world. We propose that general positions on this debate are less helpful than drawing lessons from specific investigations into the features of individual projects that make them successful or not. Here, focusing on a site-specific REDD+ intervention in Pemba, Zanzibar (Tanzania), we examine the circumstances under which REDD+ has a chance of success, teasing out specific features of both REDD+ interventions and the socio-economic and institutional contexts that render REDD+ a potentially valuable complement to community forestry. Additionally, we highlight some unanticipated positive outcomes associated with the design features of REDD+ projects. Our broader goal is to move away from ideologically-driven debate to empirically-based identification of general conditions where REDD+ could work, and to provide policy recommendations.
A Comparison of the Greek ACE-III, M-ACE, ACE-R, MMSE, and ECAS in the Assessment and Identification of Alzheimer’s Disease
Authors: Kourtesis Panagiotis , Margioti Eleni , Demenega Christina , Christidi Foteini , Abrahams Sharon 
Published: April 2020

AbstractObjective:This study aimed to adapt the Addenbrooke’s Cognitive Examination-III (ACE-III) and Mini-Addenbrooke’s Cognitive Examination (M-ACE) into Greek and then to examine the convergent validity against their predecessors Addenbrooke’s Cognitive Examination-Revised (ACE-R) and Mini-Mental State Examination (MMSE) in a Greek population. Moreover, a primary aim was to appraise the utility of each screen by conducting a comparison of the psychometric properties of ACE-III, M-ACE, ACE-R, MMSE, and the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis (ALS) Screen (ECAS) in detecting Alzheimer’s disease (AD).Methods:Forty patients with AD were recruited and matched with 38 controls. Bayesian Pearson’s correlation analysis was conducted to examine the convergent validity. Receiver operating characteristic curve analysis was implemented to appraise the sensitivity and specificity of the tests in detecting AD.Results:The ACE-III, M-ACE, and the ECAS scores robustly correlated with ACE-R and MMSE. The ACE-III and the ECAS-ALS Non-Specific score were the most sensitive and specific tools in detecting AD, closely followed by ECAS Total score and M-ACE. Only ECAS Total score correlated with the duration of disease. The ECAS scores were more resilient to ceiling effects than the other screens. M-ACE produced fewer ceiling effects than MMSE.Conclusion:The Greek ACE-III and M-ACE were successfully adapted and showed good convergent validity against their predecessors. They showed very good psychometric properties in detecting AD and may be considered in hectic clinical settings. ECAS Total score and ECAS-ALS Non-Specific showed comparable psychometric properties in the detection of AD and may be considered in polypathological clinics where motor impairments are common.
Cognitive Reserve Proxies Do Not Differentially Account for Cognitive Performance in Patients with Focal Frontal and Non-Frontal Lesions
Authors: MacPherson Sarah E. , Allerhand Michael , Gharooni Sarah , Smirni Daniela , Shallice Tim , Chan Edgar , Cipolotti Lisa 
Published: April 2020

AbstractObjective:Cognitive reserve (CR) suggests that premorbid efficacy, aptitude, and flexibility of cognitive processing can aid the brain’s ability to cope with change or damage. Our previous work has shown that age and literacy attainment predict the cognitive performance of frontal patients on frontal-executive tests. However, it remains unknown whether CR also predicts the cognitive performance of non-frontal patients.Method:We investigated the independent effect of a CR proxy, National Adult Reading Test (NART) IQ, as well as age and lesion group (frontal vs. non-frontal) on measures of executive function, intelligence, processing speed, and naming in 166 patients with focal, unilateral frontal lesions; 91 patients with focal, unilateral non-frontal lesions; and 136 healthy controls.Results:Fitting multiple linear regression models for each cognitive measure revealed that NART IQ predicted executive, intelligence, and naming performance. Age also signiﬁcantly predicted performance on the executive and processing speed tests. Finally, belonging to the frontal group predicted executive and naming performance, while membership of the non-frontal group predicted intelligence.Conclusions:These ﬁndings suggest that age, lesion group, and literacy attainment play independent roles in predicting cognitive performance following stroke or brain tumour. However, the relationship between CR and focal brain damage does not differ in the context of frontal and non-frontal lesions.
Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function
Authors: Giegling Ina , Hartmann Annette M. , Genius Just , Konte Bettina , Maul Stephan , Straube Andreas , Eggert Thomas , Mulert Christoph , Leicht Gregor , Karch Susanne , Hegerl Ulrich , Pogarell Oliver , Hölter Sabine M. , Möller Hans-Jürgen , Graw Jochen , Rujescu Dan 
Published: April 2020

AbstractβB2-crystallin (gene symbol: Crybb2/CRYBB2) was first described as a structural protein of the ocular lens before it was detected in various brain regions of the mouse, including the hippocampus and the cerebral cortex. Mutations in the mouse Crybb2 gene lead to alterations of sensorimotor gating measured as prepulse inhibition (PPI) and reduced hippocampal size, combined with an altered number of parvalbumin-positive GABAergic interneurons. Decreased PPI and alterations of parvalbumin-positive interneurons are also endophenotypes that typically occur in schizophrenia. To verify the results found in mice, we genotyped 27 single nucleotide polymorphisms (SNPs) within the CRYBB2 gene and its flanking regions and investigated different schizophrenia typical endophenotypes in a sample of 510 schizophrenia patients and 1322 healthy controls. In the case-control study, no association with schizophrenia was found. However, 3 of the 4 investigated haplotype blocks indicated a decreased CRYBB2 mRNA expression. Two of these blocks were associated with poorer antisaccade task performance and altered working memory-linked functional magnetic resonance imaging signals. For the two haplotypes associated with antisaccade performance, suggestive evidence was found with visual memory and in addition, haplotype block 4 showed a nominally significant association with reduced sensorimotor gating, measured as P50 ratio. These results were not schizophrenia-specific, but could be detected in a combined sample of patients and healthy controls. This is the first study to demonstrate the importance of βB2-crystallin for antisaccade performance and memory function in humans and therefore provides implications for βB2-crystallin function in the human brain.
LncRNA GOLGA2P10 is induced by PERK/ATF4/CHOP signaling and protects tumor cells from ER stress-induced apoptosis by regulating Bcl-2 family members
Authors: Wu Meng-Zhi , Fu Tao , Chen Jin-Xi , Lin Ying-Ying , Yang Jin-E , Zhuang Shi-Mei 
Published: April 2020

AbstractElevated endoplasmic reticulum (ER) stress is frequently observed in cancers, whereas sustained ER stress may trigger apoptosis. How cancer cells escape from ER stress-induced apoptosis remain unclear. Here, we found that a pseudogene-derived lncRNA, Golgin A2 pseudogene 10 (GOLGA2P10), was frequently upregulated in HCC tissues and significantly elevated in hepatoma cells treated with ER stress inducers, such as tunicamycin and thapsigargin. Higher GOLGA2P10 level was correlated with shorter recurrence-free survival of HCC patients. Upon ER stress, CHOP directly bound to the promoter of GOLGA2P10 and induced its transcription via the PERK/ATF4/CHOP pathway. Interestingly, the ER stress inducer-stimulated apoptosis was promoted by silencing GOLGA2P10 but was antagonized by overexpressing GOLGA2P10. Both gain- and loss-of-function analyses disclosed that GOLGA2P10 increased BCL-xL protein level, promoted BAD phosphorylation, and conferred tumor cells with resistance to ER stress-induced apoptosis. Moreover, BCL-xL overexpression or BAD knockdown abrogated the apoptosis-promoting effect of GOLGA2P10 silencing. Consistently, the Ser75Ala mutation in BAD, which caused phosphorylation-resistance, further enhanced the promoting effect of BAD in tunicamycin-induced apoptosis. These results suggest that ER stress induces GOLGA2P10 transcription through the PERK/ATF4/CHOP pathway, and upregulation of GOLGA2P10 protects tumor cells from the cytotoxic effect of persistent ER stress in tumor microenvironment by regulating Bcl-2 family members, which highlight GOLGA2P10 as a potential target for anticancer therapy.
E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway
Authors: Yu Yan , Zhao Dan , Li Kongfei , Cai Yubo , Xu Penglin , Li Rui , Li Juan , Chen Xiaolong , Chen Ping , Cui Guangying 
Published: April 2020

AbstractThe DEAD/DEAH box helicase 11 (DDX11) plays vital roles in regulating the initiation of DNA replication. However, its precise function and regulation in hepatocellular carcinoma (HCC) have never been reported yet. In the current study, we found that DDX11 was overexpressed in HCC tissues. High DDX11 expression was positively correlated with large tumor size, tumor multiplicity, late tumor-node-metastasis (TNM) stage and poor prognosis. Additional, gain-of-function and loss-of-function experimental results revealed that DDX11 overexpression promoted HCC cell proliferation, migration, invasion and inhibited cell apoptosis in vitro. Overexpression of DDX11 also enhanced HCC tumorigenicity in vivo. Furthermore, DDX11 was transcriptionally regulated by transcription factor E2F1 in HCC, as demonstrated by chromatin immunoprecipitation (Ch-IP) and luciferase reporter assays. Mechanistically, E2F1/DDX11 axis promoted HCC cell proliferation, migration and invasion, at least in part, through activating PI3K/AKT/mTOR signaling pathway. Conclusively, our study demonstrates that E2F1-enhanced DDX11 expression promotes HCC progression through PI3K/AKT/mTOR pathway and DDX11 might be a potential therapeutic and prognostic target for HCC treatment.
Oceanic crust recycling controlled by weakening at slab edges
Authors: Munch Jessica , Gerya Taras , Ueda Kosuke 
Published: April 2020

AbstractRetreating subduction zones such as the Lesser Antilles, Gibraltar and Scotia have been migrating towards the Atlantic Ocean by cutting their way through the oceanic crust. This spontaneously retreating subduction is enabled by the development of faults at the edges of the slab, but the physical mechanisms controlling fault propagation and direction remain unknown. Here, using 3D numerical subduction models we show that oceanic lithosphere recycling is mainly controlled by the intensity of strain-induced weakening of fractures forming at the edges of the slab. Intense strain-induced weakening causes predominantly brittle fault propagation and slab narrowing until detachment. Without weakening, preponderantly ductile slab edge propagation occurs, which causes slab widening. This rheological control is not affected by the proximity of non-weakened passive continental margins. Natural examples suggest that slab edges follow convergent paths that could be controlled by fractures weakening due to deep water penetration into the oceanic lithosphere.
Non-linear interaction modulates global extreme sea levels, coastal flood exposure, and impacts
Authors: Arns Arne , Wahl Thomas , Wolff Claudia , Vafeidis Athanasios T. , Haigh Ivan D. , Woodworth Philip , Niehüser Sebastian , Jensen Jürgen 
Published: April 2020

AbstractWe introduce a novel approach to statistically assess the non-linear interaction of tide and non-tidal residual in order to quantify its contribution to extreme sea levels and hence its role in modulating coastal protection levels, globally. We demonstrate that extreme sea levels are up to 30% (or 70 cm) higher if non-linear interactions are not accounted for (e.g., by independently adding astronomical and non-astronomical components, as is often done in impact case studies). These overestimates are similar to recent sea-level rise projections to 2100 at some locations. Furthermore, we further find evidence for changes in this non-linear interaction over time, which has the potential for counteracting the increasing flood risk associated with sea-level rise and tidal and/or meteorological changes alone. Finally, we show how accounting for non-linearity in coastal impact assessment modulates coastal exposure, reducing recent estimates of global coastal flood costs by ~16%, and population affected by ~8%.
Recent hemispheric asymmetry in global ocean warming induced by climate change and internal variability
Authors: Rathore Saurabh , Bindoff Nathaniel L. , Phillips Helen E. , Feng Ming 
Published: April 2020

AbstractRecent research shows that 90% of the net global ocean heat gain during 2005–2015 was confined to the southern hemisphere with little corresponding heat gain in the northern hemisphere ocean. We propose that this heating pattern of the ocean is driven by anthropogenic climate change and an asymmetric climate variation between the two hemispheres. This asymmetric variation is found in the pre-industrial control simulations from 11 climate models. While both layers (0–700 m and 700–2000 m) experience steady anthropogenic warming, the 0–700 m layer experiences large internal variability, which primarily drives the observed hemispheric asymmetry of global ocean heat gain in 0–2000 m layer. We infer that the rate of global ocean warming is consistent with the climate simulations for this period. However, the observed hemispheric asymmetry in heat gain can be explained by the Earth’s internal climate variability without invoking alternate hypotheses, such as asymmetric aerosol loading.
Polyamide nanofiltration membrane with highly uniform sub-nanometre pores for sub-1 Å precision separation
Authors: Liang Yuanzhe , Zhu Yuzhang , Liu Cheng , Lee Kueir-Rarn , Hung Wei-Song , Wang Zhenyi , Li Youyong , Elimelech Menachem , Jin Jian , Lin Shihong 
Published: April 2020

AbstractSeparating molecules or ions with sub-Angstrom scale precision is important but technically challenging. Achieving such a precise separation using membranes requires Angstrom scale pores with a high level of pore size uniformity. Herein, we demonstrate that precise solute-solute separation can be achieved using polyamide membranes formed via surfactant-assembly regulated interfacial polymerization (SARIP). The dynamic, self-assembled network of surfactants facilitates faster and more homogeneous diffusion of amine monomers across the water/hexane interface during interfacial polymerization, thereby forming a polyamide active layer with more uniform sub-nanometre pores compared to those formed via conventional interfacial polymerization. The polyamide membrane formed by SARIP exhibits highly size-dependent sieving of solutes, yielding a step-wise transition from low rejection to near-perfect rejection over a solute size range smaller than half Angstrom. SARIP represents an approach for the scalable fabrication of ultra-selective membranes with uniform nanopores for precise separation of ions and small solutes.