bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulsar Timing Array Constraints on the Merger Timescale of Subparsec Supermassive Black Hole Binary Candidates
Authors: Nguyen Khai , Bogdanović Tamara , Runnoe Jessie C. , Taylor Stephen R. , Sesana Alberto , Eracleous Michael , Sigurdsson Steinn 
Published: September 2020

Abstract
We estimate the merger timescale of spectroscopically selected, subparsec supermassive black hole binary (SMBHB) candidates by comparing their expected contribution to the gravitational-wave background (GWB) with the sensitivity of current pulsar timing array (PTA) experiments and in particular, with the latest upper limit placed by the North American Nanohertz Observatory for Gravitational Waves. We find that the average timescale to coalescence of such SMBHBs is

yr, assuming that their orbital evolution in the PTA frequency band is driven by emission of gravitational waves. If some fraction of SMBHBs do not reside in spectroscopically detected active galaxies, and their incidence in active and inactive galaxies is similar, then the merger timescale could be ∼10 times longer,

yr. These limits are consistent with the range of timescales predicted by theoretical models and imply that all the SMBHB candidates in our spectroscopic sample could be binaries without violating the observational constraints on the GWB. This result illustrates the power of the multimessenger approach, facilitated by the PTAs, in providing an independent statistical test of the nature of SMBHB candidates discovered in electromagnetic searches.
Prediction of Work Impact in Axial Spondyloarthritis by the Work Instability Scale: A Prospective Cohort Study of 101 Patients
Authors: Cucos Irina , Dadoun Sabrina , Jacquemin Charlotte , Kreis Sarah , Fabre Stephanie , Hudry Christophe , Pertuiset Eduard , Fautrel Bruno , Gossec Laure 
Published: September 2020

Objective.Axial spondyloarthritis (axSpA) may have an effect on work. The Ankylosing Spondylitis Work Instability Scale (AS-WIS) assesses difficulties at work. The objective of this study was to evaluate the predictive value of the AS-WIS on work impact.Methods.This is a prospective cohort study with 2 timepoints (at baseline and after 1.5 yrs) that included patients with axSpA who had paid employment. Patients completed the AS-WIS at baseline and work instability was scored as moderate/high if ≥ 11 (0–20 scale). At follow-up, adverse work outcomes (AWO) were grouped as moderate (short-term sick leave) or severe AWO (long-term sick leave, disability, unemployment). Univariable and multivariable logistic regression analyses were performed to explain AWO.Results.Of 101 patients, mean age 45 (SD 9) years, 52% male, disease duration was 14 (SD 8) years. The Bath AS Disease Activity Index and the Bath AS Functional Index were 34 (SD 21) and 23 (SD 23), respectively, and 69 (68%) received a tumor necrosis factor inhibitor. At baseline, 46 (46%) patients had moderate/high AS-WIS. At 1.5 years of follow-up, 37 patients (36%) had AWO: 25 patients (25%) a short-term sick leave, and 12 patients (12%, 7/100 patient-years) a severe AWO. Independent baseline factors associated with AWO were a moderate/high AS-WIS score (OR 2.71, 95% CI 1.04–7.22) and shorter disease duration (OR 0.94, 95% CI 0.89–0.99).Conclusion.In patients with axSpA, a moderate/high AS-WIS score was predictive of AWO in this population with well-controlled axSpA. This short questionnaire can be helpful to screen for future difficulties at work.
Evaluating Quality of Care for Rheumatoid Arthritis for the Population of Alberta Using System-level Performance Measures
Authors: Barber Claire E.H. , Lacaille Diane , Faris Peter , Mosher Dianne , Katz Steven , Patel Jatin N. , Zhang Sharon , Yee Karen , Barnabe Cheryl , Hazlewood Glen S. , Bykerk Vivian , Shiff Natalie J. , Twilt Marinka , Burt Jennifer , Benseler Susanne M. , Homik Joanne , Marshall Deborah A. 
Published: September 2020

ObjectiveWe evaluated 4 national rheumatoid arthritis (RA) system-level performance measures (PM) in Alberta, Canada.MethodsIncident and prevalent RA cases ≥ 16 years of age since 2002 were identified using a validated case definition applied in provincial administrative data. Performance was ascertained through analysis of health data between fiscal years 2012/13–2015/16. Measures evaluated were as follows: proportion of incident RA cases with a rheumatologist visit within 1 year of first RA diagnosis code (PM1); proportion of prevalent RA patients who were dispensed a disease-modifying antirheumatic drug (DMARD) annually (PM2); time from first visit with an RA code to DMARD dispensation and proportion of incident cases where the 14-day benchmark for dispensation was met (PM3); and proportion of patients seen in annual follow-up (PM4).ResultsThere were 31,566 prevalent and 2730 incident RA cases (2012/13). Over the analysis period, the proportion of patients seen by a rheumatologist within 1 year of onset (PM1) increased from 55% to 63%; however, the proportion of RA patients dispensed DMARD annually (PM2) remained low at 43%. While the median time to DMARD from first visit date in people who received DMARD improved over time from 39 days to 28 days, only 38–41% of patients received treatment within the 14-day benchmark (PM3). The percentage of patients seen in yearly follow-up (PM4) varied between 73–80%.ConclusionThe existing Alberta healthcare system for RA is suboptimal, indicating barriers to accessing specialty care and treatment. Our results inform quality improvement initiatives required within the province to meet national standards of care.
National Sjögren’s Foundation Survey: Burden of Oral and Systemic Involvement on Quality of Life
Authors: McCoy Sara S. , Bartels Christie M. , Saldanha Ian J. , Bunya Vatinee Y. , Akpek Esen K. , Makara Matthew A. , Baer Alan N. 
Published: September 2020

Objective.To define the association between oral and systemic manifestations of Sjögren syndrome (SS) and quality of life (QOL).Methods.We analyzed a cross-sectional survey conducted by the Sjögren’s Foundation in 2016, with 2961 eligible responses. We defined oral symptom and sign exposures as parotid gland swelling, dry mouth, mouth ulcers/sores, oral candidiasis, trouble speaking, choking or dysphagia, sialolithiasis or gland infection, and dental caries. Systemic exposures included interstitial lung disease, purpura/petechiae/cryoglobulinemia, vasculitis, neuropathy, leukopenia, interstitial nephritis, renal tubular acidosis, autoimmune hepatitis, primary biliary cholangitis, or lymphoma. Outcomes included SS-specific QOL questions generated by SS experts and patients.Results.Using multivariable regression models adjusted for age, sex, race, and employment, we observed that mouth ulcers or sores, trouble speaking, and dysphagia were associated with poor quality of life. The following oral aspects had the greatest effect on the following QOL areas: (1) mouth ulcers/sores on the challenge and burden of living with SS (OR 4.26, 95% CI 2.89–6.28); (2) trouble speaking on memory and concentration (OR 4.24, 95% CI 3.28–5.48); and (3) dysphagia on functional interference (OR 4.25, 95% CI 3.13–5.79). In contrast, systemic manifestations were associated with QOL to a lesser extent or not at all.Conclusion.Oral manifestations of SS, particularly mouth ulcers or sores, trouble speaking, and dysphagia, were strongly associated with worse QOL. Further study and targeted treatment of these oral manifestations provides the opportunity to improve quality of life in patients with SS.
« On n’est pas des magiciens » : Le contrôleur, facilitateur de compromis dans le processus de commensuration
Authors: Jerman Lambert , Alcouffe Simon , Oriot Fabienne 
Published: September 2020

Dans cet article, nous définissons le contrôleur de gestion comme un « facilitateur de compromis » pour comprendre son influence dans le processus de commensuration des organisations et de leurs activités. Le « facilitateur de compromis » décrit les pratiques et les discours par lesquels le contrôleur bricole et adapte les indicateurs et nombres, pour les doter de l’élasticité et de la polysémie nécessaires à ce qu’ils soient largement acceptables. Au moyen d’entretiens avec les administrateurs et acteurs clés de Centres Dramatiques Nationaux (CDN), nous montrons que le contrôleur « facilitateur de compromis » se structure autour de l’absorption des contradictions, de la personnalisation de la quantification et de la mise en valeur de ses mesures et résultats pour répondre aux exigences du pilotage. Ces trois ensembles de pratiques et de discours permettent de mieux comprendre l’influence du contrôleur dans le processus de commensuration, à la fois agent d’une rationalisation du théâtre et d’une théâtralisation de la gestion. Ils éclairent la puissance et la résilience de ses ajustements, de ses savoir-faire et de ses jugements pour rendre indicateurs et nombres plus acceptables.
L’annonce d’une mauvaise nouvelle : la nécessité d’un dialogue éthique
Authors: Mounier Frédéric , Laurent Laetitia , Buard Géraldine , Goujon Patrick 
Published: September 2020

Le 16 novembre 2019, le Centre Laennec Paris et l’Université catholique de Lille ont organisé une rencontre sur un thème sensible : « Comment annoncer une mauvaise nouvelle ? », pour leurs étudiants. Laetitia Laurent, mère de deux garçons atteints de maladie orpheline, a rappelé les difficultés des parents lors de l’annonce. Puis Géraldine Buard, neurologue, est revenue sur son expérience de l’annonce de maladies neurologiques invalidantes. Enfin, Patrick Goujon, théologien et directeur du 1 er cycle au Centre Sèvres 1 , a proposé sa réflexion sur le mode d’emploi du langage en de telles occasions. L’ordre des interventions, que vous retrouverez ici, reprend le déroulé d’une consultation médicale : le médecin expose au patient son problème de santé ; il lui communique un diagnostic et lui prodigue des soins ; il relit ensuite sa pratique.
Éthique et politique du soin : quel tournant à l’occasion de la pandémie ?
Authors: Saintôt Bruno 
Published: September 2020

La pandémie de la Covid-19 n’est pas encore terminée ; ses effets sur la santé, la vie sociale, l’économie et la politique ne sont ni inventoriés ni mesurés parce qu’ils dépendent notamment de futures décisions politiques. Il serait donc prétentieux de faire des bilans et des recommandations assurés. Mais il est toutefois possible d’analyser en quoi cette pandémie devrait être l’occasion d’un tournant dans les manières collectives et professionnelles d’aborder l’éthique et la politique du soin.
Effectiveness of quadriceps muscle strengthening on knee joint stability and activities of daily living in patients with knee joint osteoarthritis
Authors: Kumarahewa C. V. , Amaratunga H. A. 
Published: September 2020

Objectives: Knee is the largest weight bearing joint in the body and thereby is affected by diseases such as osteoarthritis more frequently. The aim of this study was to evaluate the effect of a 4 week physiotherapy exercise program, designed to improve quadriceps muscle strength and girth, and to observe its effect on knee pain and activities of daily life through a pre and post exercise analysis in patients with knee joint osteoarthritis (OA). Methods: Thirty patients diagnosed with knee joint osteoarthritis irrespective of gender, over the age of 45 and less than 75 years were recruited for the study. Initially knee joint pain severity was assessed using the VAS (visual analogue scales) and WOMAC questionnaire was used to assess the activities of daily living. The thigh circumference was measured in centimeters. Data was analyzed by SPSS 20. Results: Mean age of osteoarthritis patients was 54 years. There was a statistically significant, reduction in knee pain (p=0.001), improvement of quadriceps muscles girth (p=0.012) and an improvement of daily living activities (p=0.001) after engaging in the physiotherapy exercise program. Conclusion: A four week guided quadriceps muscle strengthening exercise program can significantly increase the quadriceps muscles girth and knee joint stability and reduce pain and improve the activities of daily living in patients with knee OA.
Melatonin as an index of periodontal disease
Authors: Franco Rocco , Bollero Patrizio 
Published: September 2020

AbstractPeriodontal disease affects the supporting tissues of the tooth. The clinical manifestation varies from gingivitis to periodontitis. Periodontal disease is triggered by bacterial infection that releases toxins. The imbalance between oxidants and antioxidants determines the progression of periodontal disease. Melatonin (MEL) (N-acetyl-5-methoxytryptamine) is a hormone in the human body. Its production takes place in various organs including the retina, gastrointestinal tract, bone marrow, leukocytes, lymphocytes, skin, and principally pineal gland. Its main function is the regulation of circadian and seasonal rhythm, body weight, reproduction, bone metabolism, and tumor growth. An important function of melatonin is the ability to reduce oxidative stress. The aim of this work is to explain if there are differences in salivary melatonin concentration between periodontal and healthy individuals. The study was conducted utilizing the main scientific databases (PubMed, MEDLINE, and Web of Science). The time window considered for the electronic search was from March 1, 2007, to March 1, 2020. The work takes into account 6 works on the disease. Other studies were excluded as they did not meet the inclusion criteria. Studies revealed a concentration of salivary melatonin compared to patients with periodontal disease. Studies agree that the concentration of melatonin is lower in people with periodontal disease. Only one study showed no difference in concentration. Melatonin, therefore, has a protective effect on the periodontium thanks to its antioxidant properties. The salivary measurement of melatonin could be a useful tool for early detection. It can also be used as a therapy to improve the symptoms of periodontal disease.
Breast uptake on a myocardial perfusion scan
Authors: Morales Cristina , Apostol Angelin 
Published: September 2020

AbstractA 42-year-old female underwent a myocardial perfusion scan (MPS) for the evaluation of coronary artery disease. Raw and cine loop images hinted at abnormal tracer accumulation in the chest. Review of short-axis slices and low-dose computed tomography images taken for attenuation correction and their subsequent fusion confirmed the presence of focal tracer uptake localized to nodular breast masses. This case demonstrates that despite MPS not being optimized to detect breast pathologies, careful inspection of unprocessed images and the application of available software for fusion can help detect concurrent pathology.
A case of dermatopathic lymphadenitis mimicking lymphoma on 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging
Authors: Ng Koon , Hui Yan , Kung Boom , Au Yong Ting 
Published: September 2020

AbstractThis case report illustrates a rare case of dermatopathic lymphadenitis with interval 18F-fluorodeoxyglucose positron emission tomography/computed tomography performed. The clinical presentation, imaging, and histological findings are described. We discuss the diagnostic challenges in this case.
Trends in the utilization of nuclear medicine technology in Jamaica: Audit of a private facility
Authors: Kennedy-Dixon Tracia-Gay , McDonnough Karlene , Reid Marvin , Gossell-Williams Maxine 
Published: September 2020

AbstractThis study sought to evaluate the types and frequencies of nuclear medicine studies that were carried out at a privately-run nuclear medicine facility in Kingston, Jamaica. Previous studies of this nature have not been done among this population, therefore the researchers sought to gather data which may prove to be useful for the growth of nuclear medicine practice in Jamaica. The study was a nonexperimental, retrospective study which involved an assessment of the records of all nuclear medicine patients who received a radiopharmaceutical during January 01, 2017, to December 31, 2018. The data extracted included age, gender, radiopharmaceutical administered, indication for study, and impression from scan. The total number of nuclear medicine scans that were carried out at the facility for the 2-year period was 3756. Of this number, 1889 (50.3%) were male and 1866 (49.7%) were female, with the age ranging from 3 months to 100 years. The types and frequencies of the most frequently occurring studies conducted were bone (2116, 56.3%), renal (867, 23.1%), thyroid (307, 8.2%), and lung (254, 6.8%). Patients aged 60 years and over accounted for the majority of the bone scans (1353/2116). The age group 26–59 years accounted for most of the scans of the lung (123/254), thyroid (209/307), parathyroid (34/65), and whole body (26/34). Patients under 12 years of age accounted for the majority of the renal (596/867), gastrointestinal (22/26), and hepatobiliary (16/28) scans. The audit of this private facility reflects the documented demand on the International Atomic Energy Agency database for Latin America and the Caribbean, and demonstrates the need for continuity of this specialized service in our population.
Genetic diversity of sorghum (<i>Sorghum bicolor </i>(L) Moench) accessions from thirteen regions of Burkina Faso
Authors: Nikiema S. Zara , Sanou Jacob , Ouedraogo Banse , Gracen Vernon , Tongoona B. Pangirayi , Kwame Samuel Offei 
Published: September 2020

Sorghum (Sorghum bicolor (L.) Moench) is a staple food crop for West African countries in general and Burkina Faso in particular. It is mainly grown by small holder farmers for their livelihoods. They grow their landraces which is a mixture of more than two varieties. Unfortunately, the yields of farmer varieties are low compared to improved ones bred by sorghum breeders with the potential up to 3t/ha. The objective of the study was to identify the genetic diversity between improved varieties released by research institutions and farmer accessions at the molecular level. DNA sample were collected from hundred and twenty-three accessions collected from thirteen regions of Burkina Faso. DNA samples were successfully genotyped using a multiplexed complex of 28 microsatellites DNA markers for 110 genotypes. The sorghum genotypes comprised of Guinea, Caudatum and Guinea-Caudatum races. Farmer varieties were defined mainly in Guinea and Guinea-Caudatum races while the improved varieties were mainly Caudatum races. The inbreeding level FIS (the inbreeding level within a given population) for each group improved, farmer varieties varied between -1 <FIS>1. This shows the autogenous nature of sorghum varieties. Breeding schemes can therefore be designed for improvement of farmer preferred varieties.Keywords: Sorghum Microsatellites, Guinea, Caudatum, Yield, Landraces
INVESTIGATION OF CHLOROPHYLL PIGMENT CONCENTRATION AND SEA SURFACE TEMPERATURE OF THE LAKE VAN
Authors: Kavak Mehmet Tahir 
Published: September 2020

Current study is investigated chlorophyll-a (Chl-a) pigment concentration and its relationship with Sea Surface Temperature (SST) using cloud-free high resolution 59 Landsat-The Operational Land Imager (OLI) images from May 2013 to September 2018 covering Lake Van of Turkey. In addition, the concentrations of coccolithophore which is a kind of phytoplankton was also studied using the same method.
The fact that Van Lake is extremely rich in terms of aquatic life has led to the investigation of the factors affecting the marine habitat. Therefore, SST, Chl-a concentrations, as well as the relationship between them and coccolithophore concentrations were investigated to evaluate marine life and ecosystem in the Lake. Satellite-generated data can provide information about the marine life in a particular area worldwide. Coccolithophore, SST and Chl-a were obtained from high resolution 59 Landsat OLI using SeaDAS software. Aforementioned parameters were extracted from images using SeaDAS's OCSSW L2GEN module and then output processed by QGIS (Open Source Geographic Information System) to conduct statistical calculation. Negative correlation coefficients of 74% and 73.7% were found for 2014 and 2017, respectively, and these were not statistically significant. Although the information does not give meaningful results, it may be useful in future studies about the effects of global temperature changes and the marine life for particular region.
ANALISA PENYAKIT KECACINGAN, TINGKAT ASUPAN ZAT GIZI DENGAN KEJADIAN ANEMIA PADA ANAK SEKOLAH DASAR DI SD INPRES SEREH DISTRIK SENTANI KABUPATEN JAYAPURA
Authors: Iriyanti Sri , Gultom Marlin Paulina , Raya Maxianus Kopong 
Published: September 2020

Latar belakang: Anak usia sekolah merupakan salah satu kelompok yang sering terkena anemia karena pada masa ini anak masih dalam masa pertumbuhan dan mempunyai aktifitas yang tinggi. Berdasarkan data Riskesdas 2007, prevalensi anemia pada anak < 14 tahun di Provinsi Papua sebesar 16,7 %, lebih tinggi dari prevalensi anemia nasional yaitu 14,8 %. Penelitian ini bertujuan untuk menganalisa penyakit kecacingan dan tingkat asupan zat gizi dengan kejadian anemia pada anak sekolah dasar di SD Inpres Sereh Distrik Sentani Kabupaten Jayapura.
Metode : Penelitian observasional analitik ini menggunakan rancangan Cross Sectional. Populasi adalah seluruh anak sekolah dasar di SD Inpres Sereh usia 9 â€“ 11 tahun di Distrik Sentani. Sampel sebanyak 64 orang yag dipilih dengan purposive sampling. Variabel bebas yang diteliti meliputi penyakit kecacingan dan asupan gizi (energi, protein, Fe, vitamin C). Variabel terikat yaitu kejadian anemia, yang ditentukan berdasarkan pemeriksaan kadar hemoglobin dengan metode cyanmethemoglobin. Data dianalisis dengan uji Chi-Square kemudian dilanjutkan dengan Regresi Logistik.
Hasil: Penelitian ini menunjukkan hasil prevalensi anemia anak sekolah dasar di SD Inpres Sereh Distrik Sentani sebesar 51,6 %. Hasil uji statistik dengan Chi-Square menunjukkan adanya hubungan antara asupan gizi; energi (p = 0,001), protein (p = 0,001), Fe (p = 0,004), vitamin C (p = 0,016) dengan kejadian anemia. Ada hubungan juga antara penyakit kecacingan (p = 0,000) dengan kejadian anemia pada anak sekolah dasar di SD Inpres Sereh Distrik Sentani.
Kesimpulan : Ada hubungan antara penyakit kecacingan dengan kejadian anemia (p = 0,000), asupan gizi ; energi (p = 0,001), protein (p = 0,001), Fe (p = 0,004), vitamin C (p = 0,016) dengan kejadian anemia pada anak sekolah dasar di Distrik Sentani Kabupaten Jayapura.

Kata kunci	: Anak sekolah, Anemia, Asupan gizi, Kecacingan ,
Gambaran Faktor-Faktor Yang Mempengaruhi Perkembangan Motorik Pada Balita Usia 4-5 Tahun Di Tk Siswa Harapan, Ciliwung - Surabaya
Authors: Rhomadona Shinta Wurdiana 
Published: September 2020

Pendahuluan: Perkembangan anak yang optimal tergantung pada berkembangnya kemampuan dan ketrampilan motorik, baik motorik kasar maupun halus. Namun tidak semua balita dapat berkembang seperti yang seharusnya, terkadang ada balita yang lambat atau menyimpang dari kemampuan yang seharusnya dimiliki pada tahapan usianya. Proses perkembangan motorik dipengaruhi oleh beberapa faktor yaitu motivasi belajar anak, pengetahuan ibu, lingkungan pengasuhan, teman sebaya, stimulasi, tingkat gizi. Tujuan : Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi perkembangan motorik pada balita usia 4-5 tahun di TK Siswa Harapan Ciliwung Surabaya. Metode : Penelitian dilakukan menggunakan metode deskriptif korelatif dengan populasi balita usia 4–5 tahun beserta orang tuanya, yang berjumlah 20 orang. Sampel berjumlah 19 orang yang diambil menggunakan teknik purposive sampling. Teknik analisis data dengan menggunakan distribusi frekuensi dan tabulasi silang. Pengumpulan data dengan menggunakan kuisioner dan lembar DDST. Hasil: Hasil penelitian menunjukan bahwa faktor-faktor yang mempengaruhi perkembangan motorik pada balita usia 4-5 tahun adalah faktor gizi, faktor lingkungan, dan faktor stimulasi. Sedangkan faktor yang tidak mempengaruhi adalah faktor pengetahuan. Disarankan pihak TK dapat bekerja sama dengan instansi kesehatan untuk meningkatkan peran orang tua dalam memantau perkembangan motorik pada balitanya.