bluuebunny/crossref_metadata_2025_split huggingface dataset:
Warm dense matter and cooling of supernovae remnants
Authors: Kumar Ankit , Das H. C. , Biswal S. K. , Kumar Bharat , Patra S. K. 
Published: August 2020

AbstractWe study the thermal effects on the nuclear matter (NM) properties such as binding energy, incompressibility, free symmetry energy and its coefficients using NL3, G3 and IU-FSU parameter sets of relativistic mean-field models. These models being consistent with the properties of cold NM, have also been used to study the effect of temperature by incorporating the Fermi function. The critical temperature for the liquid-gas phase transition in the symmetric NM is found to be 14.60, 15.37 and 14.50 MeV for NL3, G3 and IU-FSU parameter sets respectively, which is in excellent agreement with previous theoretical and experimental studies. We inspect that the properties related to second differential coefficient of the binding energy and free symmetry energy at saturation density ( i.e. $$K_{0}(n,T)$$K0(n,T) and $$Q_{sym,0}$$Qsym,0 ) exhibit the contrary effects for NL3 and G3 parameters as the temperature increases. We find that the prediction of saturated curvature parameter ( $$K_{sym,0}$$Ksym,0 ) for G3 equation of state at finite temperature favour the combined analysis of $$K_{sym,0}$$Ksym,0 for the existence of massive pulsars, gravitational waves from GW170817 and NICER observations of PSR J0030+0451. Further, we investigate the cooling mechanism of newly born stars through neutrino emissivity controlled by direct Urca process and instate some interesting remarks about neutrino emissivity. We also deliberate the effect of temperature on the M-R profile of Proto-Neutron star.
Decay, amplification and absorption of initial terahertz pulse in resonant two-level medium based on noninteracting array of zigzag nanotubes and armchair nanoribbons
Authors: Sadykov N. R. , Peshkov D. A. , Aporoski A. V. , Belonenko M. B. 
Published: August 2020

Theoretical investigation and computer simulation of the evolution of terahertz (THz) radiation in a two-level resonance gain medium was carried out on the basis of Maxwell–Bloch equations, using the slowly varying amplitude approximation. The gain medium is based on a system of noninteracting parallel-oriented metallic carbon nanotubes and nanoribbons. Considering the Maxwell–Garnett theory (MGT), the effective dielectric function (EDF) of the medium was obtained. Due to the large nanotube dipole moment (or large value of oscillator strength) not only THz radiation occurs, but also a totality of periodic pulses generation. Results of simulation totally coincide with the theoretical ones. The equation for the phase by analogy with the self-induced transparency (SIT), taking into account the dissipative processes, was obtained. The obtained equation describes a mathematical pendulum, where friction force is proportional to the velocity and directed to the opposite of particle movement. The friction leads to the fact that the pendulum makes a full rotation around the axis or decays, depending on the absorption properties of a gain medium. It was shown that at the certain properties of a gain medium, the equation coincides with the well-known Sine-Gordon equation. It was obtained, that at the initial pumping [Formula: see text] m[Formula: see text] and at the volume fraction of nanoparticles about 10[Formula: see text], the stationary value of radiation energy in a resonator is about 1 J/m3.
Analyzing Genetic Testing Discourse on the Web Through the Lens of Twitter, Reddit, and 4chan
Authors: Mittos Alexandros , Zannettou Savvas , Blackburn Jeremy , Cristofaro Emiliano De 
Published: August 2020

Recent progress in genomics has enabled the emergence of a flourishing market for direct-to-consumer (DTC) genetic testing. Companies like 23andMe and AncestryDNA provide affordable health, genealogy, and ancestry reports, and have already tested tens of millions of customers. Consequently, news, experiences, and views on genetic testing are increasingly shared and discussed on social media. At the same time, far-right groups have also taken an interest in genetic testing, using them to attack minorities and prove their genetic “purity.”
In this article, we set to study the genetic testing discourse on a number of mainstream and fringe Web communities. We do so in two steps. First, we conduct an exploratory, large-scale analysis of the genetic testing discourse on a mainstream social network such as Twitter. We find that the genetic testing discourse is fueled by accounts that appear to be interested in digital health and technology. However, we also identify tweets with highly racist connotations. This motivates us to explore the connection between genetic testing and racism on platforms with a reputation for toxicity, namely, Reddit and 4chan, where we find that discussions around genetic testing often include highly toxic language expressed through hateful and racist comments. In particular, on 4chan’s politically incorrect board (/pol/), content from genetic testing conversations involves several alt-right personalities and openly anti-semitic rhetoric, often conveyed through memes.
TRAIL and Cancer Immunotherapy: Take a Walk on the Short Side
Authors: de Miguel Diego , Pardo Julian 
Published: August 2020

Abstract
Recent work shows that TRAILshort, a membrane-bound short form of TRAIL, is expressed by human cancer cells and protects them from TRAIL-induced cell death. A mAb that selectively targets TRAILshort enhances cancer susceptibility to TRAIL and increases the efficacy of autologous CD8+ T cells in ex vivo primary tumors.
See related article by Aboulnasr et al., p. 5759
Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer
Authors: Kawai Yoshihisa , Imada Kenjiro , Akamatsu Shusuke , Zhang Fan , Seiler Roland , Hayashi Tetsutaro , Leong Jeffrey , Beraldi Eliana , Saxena Neetu , Kretschmer Alexander , Oo Htoo Zarni , Contreras-Sanz Alberto , Matsuyama Hideyasu , Lin Dong , Fazli Ladan , Collins Colin C. , Wyatt Alexander W. , Black Peter C. , Gleave Martin E. 
Published: August 2020

Abstract
Paternally expressed gene 10 (PEG10) has been associated with neuroendocrine muscle-invasive bladder cancer (MIBC), a subtype of the disease with the poorest survival. In this work, we further characterized the expression pattern of PEG10 in The Cancer Genome Atlas database of 412 patients with MIBC, and found that, compared with other subtypes, PEG10 mRNA level was enhanced in neuroendocrine-like MIBC and highly correlated with other neuroendocrine markers. PEG10 protein level also associated with neuroendocrine markers in a tissue microarray of 82 cases. In bladder cancer cell lines, PEG10 expression was induced in drug-resistant compared with parental cells, and knocking down of PEG10 resensitized cells to chemotherapy. Loss of PEG10 increased protein levels of cell-cycle regulators p21 and p27 and delayed G1–S-phase transition, while overexpression of PEG10 enhanced cancer cell proliferation. PEG10 silencing also lowered levels of SLUG and SNAIL, leading to reduced invasion and migration. In an orthotopic bladder cancer model, systemic treatment with PEG10 antisense oligonucleotide delayed progression of T24 xenografts. In summary, elevated expression of PEG10 in MIBC may contribute to the disease progression by promoting survival, proliferation, and metastasis. Targeting PEG10 is a novel potential therapeutic approach for a subset of bladder cancers.
Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody
Authors: Al-Khami Amir A. , Youssef Sawsan , Abdiche Yasmina , Nguyen HoangKim , Chou Joyce , Kimberlin Christopher R. , Chin Sherman M. , Kamperschroer Cris , Jessen Bart , Kern Brent , Budimir Natalija , Dillon Christopher P. , Xu Allison , Clark Jerry D. , Chou Jeffrey , Kraynov Eugenia , Rajpal Arvind , Lin John C. , Salek-Ardakani Shahram 
Published: August 2020

Abstract
Development of antagonistic mAbs that specifically target the immune checkpoint receptor, programmed cell death protein-1 (PD-1), is of great interest for cancer immunotherapy. Here, we report the biophysical characteristics and nonclinical antagonistic activities of sasanlimab (PF-06801591), a humanized anti-PD-1 antibody of IgG4 isotype. We show that sasanlimab binds selectively and with similar high potency to human and cynomolgus monkey PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, with no detectable Fc-dependent effector function. The binding of sasanlimab to human and cynomolgus PD-1 is associated with the formation of a stable complex, which is likely to be the main driver of this high-affinity interaction. In vitro, sasanlimab significantly augmented T-cell proliferation and cytokine production in mixed lymphocyte reaction and superantigen stimulation assays. In vivo, sasanlimab accelerated the incidence of GvHD by enhancing T-cell proliferation and cytokine secretion in a xenogeneic model of acute GvHD and halted the growth of MC-38 colon adenocarcinoma tumors in human PD-1 knock-in mice. Pharmacokinetic and toxicokinetic findings from cynomolgus monkey showed that sasanlimab was active and well-tolerated. Taken together, the data presented here support the clinical development of sasanlimab for the treatment of patients with advanced cancers as a single agent or in combination with other immunotherapies.
The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA
Authors: Sugimoto Yohei , Katsumi Yoshiki , Iehara Tomoko , Kaneda Daisuke , Tomoyasu Chihiro , Ouchi Kazutaka , Yoshida Hideki , Miyachi Mitsuru , Yagyu Shigeki , Kikuchi Ken , Tsuchiya Kunihiko , Kuwahara Yasumichi , Sakai Toshiyuki , Hosoi Hajime 
Published: August 2020

Abstract
Rhabdoid tumor is an aggressive, early childhood tumor. Biallelic inactivation of the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)/integrase interactor 1 (INI1) gene is the only common genetic feature in rhabdoid tumors. Loss of SMARCB1 function results in downregulation of several tumor suppressor genes including p16, p21, and NOXA. The novel histone deacetylase inhibitor, OBP-801, induces p21 and has shown efficacy against various cancers. In our study, OBP-801 strongly inhibited the cell growth of all rhabdoid tumor cell lines in WST-8 assay. However, Western blotting and cell-cycle analysis revealed that OBP-801 did not activate the P21-RB pathway in some cell lines. p21 knockout indicated that p21 did not dominate the OBP-801 antitumor effect in rhabdoid tumor cell lines. We discovered that OBP-801 induced NOXA expression and caspase-dependent apoptosis in rhabdoid tumor cell lines independent of TP53. Chromatin immunoprecipitation assay showed that OBP-801 acetylated histone proteins and recruited RNA polymerase II to the transcription start site (TSS) of the NOXA promotor. Moreover, OBP-801 recruited BRG1 and BAF155, which are members of the SWI/SNF complex, to the TSS of the NOXA promotor. These results suggest that OBP-801 epigenetically releases the silencing of NOXA and induces apoptosis in rhabdoid tumors. OBP-801 strongly inhibited tumor growth in human rhabdoid tumor xenograft mouse models in vivo. Terminal deoxynucleotidyl transferase–mediated dUTP nick end labeling and cleaved caspase-3 were stained in tumors treated with OBP-801. In conclusion, OBP-801 induces apoptosis in rhabdoid tumor cells by epigenetically releasing the silencing of NOXA, which is a key mediator of rhabdoid tumor apoptosis. The epigenetic approach for NOXA silencing with OBP-801 is promising for rhabdoid tumor treatment.
The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non–Small Cell Lung Cancer
Authors: Hakozaki Taiki , Richard Corentin , Elkrief Arielle , Hosomi Yukio , Benlaïfaoui Myriam , Mimpen Iris , Terrisse Safae , Derosa Lisa , Zitvogel Laurence , Routy Bertrand , Okuma Yusuke 
Published: August 2020

Abstract
The gut microbiome (GM) plays an important role in shaping systemic immune responses and influences immune checkpoint inhibitor (ICI) efficacy. Antibiotics worsen clinical outcomes in patients receiving ICI. However, whether GM profiling and baseline antibiotic can be a biomarker of ICI efficacy in advanced non–small cell lung cancer (NSCLC) remains unknown. We prospectively collected baseline (pre-ICI) fecal samples and clinical data of 70 Japanese patients suffering from advanced NSCLC and treated them with anti–PD-1/PD-L1 antibodies as a first-line or treatment-refractory therapy. We performed 16S rRNA V3–V4 sequencing of gene amplicons of fecal samples, and bacteria diversity and differential abundance analysis was performed. The clinical endpoints were objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and immune-related adverse events (irAE). ORR was 34%, and median PFS and OS were 5.2 and 16.2 months, respectively. Patients who received pre-ICI antibiotic had lower alpha diversity at baseline and underrepresentation of Ruminococcaceae UCG 13 and Agathobacter. When analyzing antibiotic-free patients, alpha diversity correlated with OS. In addition, Ruminococcaceae UCG 13 and Agathobacter were enriched in patients with favorable ORR and PFS &gt;6 months. Ruminococcaceae UCG 13 was enriched in patients with OS &gt;12 months. GM differences were observed between patients who experienced low- versus high-grade irAE. We demonstrated the negative influence of antibiotic on the GM composition and identified the bacteria repertoire in patients experiencing favorable responses to ICI.
See articles by Tomita et al., p. 1236, and Peng et al., p. 1251
SITE INDICATOR SPECIES FOR PREDICTING THE PRODUCTIVITY OF TEAK PLANTATIONS IN PHRAE PROVINCE, THAILAND
Authors: Jumwong Narinthorn , Wachrinrat Chongrak , Sungkaew Sarawood , Teerawatananon Atchara 
Published: August 2020

Site quality assessment is critically important in any tree planting activity as it may serve a range of management functions such as, optimizing productivity estimates of forest plantations. This study aimed to evaluate the site quality, using plant indicators species, for three teak plantations located in Northern Thailand belonging to the Forest Industry Organization (FIO). Twenty-four sample plots were chosen to cover all the growth classes within the age range of 6-39 years. The site index of teak was established by using the anamorphic technique which is based on dominant height and age at a base age of 30 years, divided into 3 site index classes as 24, 21, and 18, as good, moderate, and poor site quality, respectively. Associated species, the native species that are tree and shrub habits, were surveyed in the 24 plots and indicator species were classified using the Indicator Species Analysis (ISA) and Two Way Indicator Species Analysis (TWINSPAN). The relationship between indicator species and environmental factors was analyzed by the Generalized Linear Model (GLM). The associated species was classified into 76 species with 21 families. The results of ISA indicated the significant indicator species under the good site class were Streblus ilicifolius, Lagerstroemia floribunda, Dalbergia cana and Lagerstroemia calyculata; while Schleichera oleosa and Dalbergia nigrescens were presented under poor site class, respectively. The results from TWINSPAN supported Streblus ilicifolius, Lagerstroemia floribunda and Schleichera oleosa were obvious indicators.Â Each indicator species distribution influenced by various relationships with environmental factors, which soil pH and N were the main factors to distribute all indicator species to 3 relationships. First, the indicator species positively associated with soil pH and negatively associated with N were Streblus ilicifolius and Dalbergia nigrescens. Second, the indicator species positively associated with soil pH and N were Lagerstroemia floribunda and Schileichera oleosa. Third, the indicator species negatively associated with soil pH and positively associated N were Dalbergia cana and Lagerstroemia calyculata. The GLM analysis revealed P, Ca and elevation influenced indicator species distribution. As of writing, this is the first study on species indicators for suitable sites of teak in Thailand. Meanwhile, in the absence of confirmatory studies, these indicators can be used as guide for farmers interested in planting teak. In bare lands, the farmer can apply these indicator species to determine the site quality based on the speciesâ€™ past appearance.
O jogo performático de Oswald de Andrade no poema "Reivindicação"
Authors: Araújo Ellen Margareth Dias Ribeiro 
Published: August 2020

Este estudo objetiva discutir a subjetividade lírica no poema “reivindicação”, de Oswald de Andrade, escrito provavelmente na década de 1920. O poema “inédito” possibilita investigar a atuação do sujeito lírico em performances marcadas pela tensão ambígua entre o ficcional e o autobiográfico. Interessa evidenciar o vínculo sujeito lírico e sujeito empírico, disfarçado pelas máscaras do fingimento poético e que culmina no retorno do sujeito empírico ao poema, performando subjetividades como outro “eu”.
A preliminary checklist of spiders (Araneae: Arachnida) in Jambughoda Wildlife Sanctuary, Panchmahal District, Gujarat, India
Authors: Reshma Solanki  , Manju Siliwal  , Kumar Dolly 
Published: August 2020

Studies relating to spiders in Gujarat have been sporadic and most of the spider documentation have been done from agriculture fields, wetlands and few from protected areas. One such undocumented area was Jambughoda Wildlife Sanctuary, Panchmahal District, Gujarat. Therefore, a study to document the spider diversity was carried out in Jambughoda Wildlife Sanctuary from July 2012 to October 2015. A combination of four sampling methods namely, belt transect along with hand-pick method, pitfall sampling, vegetation beating and leaf litter extraction were used for collection of spiders from different strata. During the study, a total of 138 species belonging to 90 genera and 29 families were recorded from the study area. Of which, 21 species and 17 genera were recorded for the first time from Gujarat State. The theridiid genus Cephalobares O. Pickard-Cambridge, 1870 was recorded for the first time from India. The families Araneidae, Salticidae, Theridiidae and Oxyopidae were found to be dominant in the area. We recognized seven feeding guilds namely ambushers, foliage runners, ground runners, orb weavers, sheet web-builders, space web-builders and stalkers. Amongst these, orb-weavers, stalkers and ground runners were dominant. This documentation, however, forms the baseline information for spiders of Jambughoda WLS, suggesting the great diversity of the spider fauna in this protected area, which can be further explored.
Diversity and distribution of figs in Tripura with four new additional records
Authors: Debbarma Smita , Banik Biplab , Baishnab Biswajit , B.K. Datta  , Majumdar Koushik 
Published: August 2020

Abstract: The genus Ficus L., commonly known as Fig plays an important role in the forest ecosystem, being a keystone species. Taxonomic revision, habitat assessment, and floristic study of the genus Ficus of northeastern region are scanty and still lacking. As the genus is rich in diversity, this region possesses tremendous scope for utilisation of its members, as many species belonging to this genus carry good properties for diverse uses for the benefit of mankind. Therefore, the present study has been undertaken for identification of the collected taxa, diversity assessment of the wild as well as planted species, distribution throughout the state and preparation of a comprehensive checklist along with measures of diverse functions and ecological role of the genus Ficus in Tripura, North-East India. Field survey was conducted between April 2017–August 2018 throughout Tripura and all the locations were marked with GPS which is given in the present distribution map of Ficus in Tripura. This study is based on extensive field survey and specimen collection. Key taxonomic description, both accepted and vernacular names, phenology, and diverse habitat function of all species have been provided. Based on the available literatures, distribution information of the present records were calculated. Evaluation of diverse ecological role were scored based on the published literature and field observations. In the present study, 23 taxa of Ficus have been reported from the study area including four new distribution records. Most of the Ficus species recorded in this study were from moist mixed deciduous and secondary forests. Out of 23 species of Ficus recorded in the present study, seven (7) species belong to evergreen small tree to shrub (F. benghalensis, F. drupacea, F. elastica, F. microcarpa, F. racemosa, F. sarmentosa and F. semicordata); three (3) species recorded are large deciduous tree (F. racemosa, F. religiosa and F. rumphii). Fleshy fruited trees are the most preferable option for survival of frugivores over diverse habitats and thus, plays major role for entire ecosystem restoration. The present work will be useful to understand the critical interactions between plants and frugivore at different trophic levels. Further, Ficus groups tend to have multiple ecological roles, and as a result there exists huge scope to understand the mechanisms of plant functional traits for conservation of threatened frugivore diversity.
Notes on the occurrence of a rare pufferfish, Chelonodontops leopardus (Day, 1878) (Tetraodontiformes: Tetraodontidae), in the freshwaters of Payaswini River, Karnataka, India
Authors: Chakraborty Priyankar , Mishra Subhrendu Sekhar , Yardi Kranti 
Published: August 2020

The Banded LeopardblowFish, Chelonodontops leopardus (Day 1878) has been recorded in the freshwater region of Payaswini River, near Sullia Town, Dakshin Kannada District, Karnataka about 65km away from coastline of the Arabian Sea. The paper provides the taxonomic account of the fish and its distribution is discussed.
The first record of Montagu’s Harrier Circus pygargus (Aves: Accipitridae) in West Bengal, India
Authors: Suman Pratihar  , Mandal Niloy 
Published: August 2020

One Montagu’s Harrier Circus pygargus subadult female was identified and photographed in December, 2019 in West Bengal, India. This is the first record from the state.