bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 in a Tropical Area of Colombia, a Remarkable Conversion of Presymptomatic to Symptomatic People Impacts Public Health
Authors: Martinez Caty , Serrano Hector , Mattar Salim , Faccini-Martínez Álvaro A. , Contreras Veronica , Galeano Ketty , Botero Yesica , Herrera Yonairo , Garcia Alejandra , Garay Evelin , Rivero Ricardo , Contreras Hector , Lopez Yesica , Guzman Camilo , Miranda Jorge , Arrieta German 
Published: November 2020

Abstract
The ability of SARS-CoV-2 to remain in asymptomatic individuals facilitates its dissemination and makes its control difficult. Objective. To establish a cohort of asymptomatic individuals, change to the symptomatic state, and determine the most frequent clinical manifestations. Methods. Between April 9 and August 9, 2020, molecular diagnosis of SARS-CoV-2 infection was confirmed in 154 asymptomatic people in contact with subjects diagnosed with COVID-19. Nasopharyngeal swabs were performed on these people in different hospitals in Córdoba, the Caribbean area of Colombia. The genes E, RdRp, and N were amplified with RT-qPCR. Based on the molecular results and the Cq values, the patients were subsequently followed up through telephone calls to verify their health conditions. Results. Overall, of 154 asymptomatic individuals, 103 (66.9%) remained asymptomatic, and 51 (33.1%) changed to symptomatic. The most frequent clinical manifestations in young people were anosmia and arthralgia; in adults, they were cough, ageusia, and odynophagia; in the elderly were epigastralgia, dyspnea, and headache. Mortality was 8%. Conclusions. A proportion of 33% of presymptomatic individuals was found, of which four of them died. This high rate could indicate a silent transmission, contributing significantly to the increase in the epidemic associated with SARS-CoV-2.
Comparison of severity signs between patients with primary and secondary dengue infection during the 2016 Burkina Faso (West Africa) outbreak.
Authors: Diendéré Eric Arnaud , Sondo/Ouédraogo Apoline Kognimisson , Diallo ismael , Ky/Ba Absetou , Rouamba Toussaint , Dutertre Yann Yves , Bognounou René , Ly Djeneba , Zoungrana Jacques , Sawadogo Abdoulaye , Guira Oumar , Tieno Hervé , Poda Armel , Tinto Halidou 
Published: November 2020

Abstract
Background The factors that expose the severity of dengue are still controversial, particularly the relationship between severe dengue and secondary dengue. More importantly, the severity of dengue infection remains poorly studied in Africa. The objective of this study was to compare severity signs between patients with primary and secondary dengue infection during the 2016 dengue outbreak in Burkina Faso.Methods This was a cross-sectional study through a retrospective examination of patient medical records managed in Ouagadougou for dengue fever from 1 January 2015 to 31 December 2017. All health facilities with the capacity to perform dengue diagnosis in Ouagadougou were considered in the survey. Primary dengue was defined as the presence of AgNS1 and/or IgM and secondary dengue as the presence of IgG associated with one of these two markers. Patients with only IgG were excluded. Univariate and multivariable analyzes were performed using a logistic regression with dengue infection (primary or secondary dengue) as the binary dependent variable. The statistical significant level was set at 0.05.Results Of the 811 patients managed for dengue fever during the study period, 418 (51.5%) were male. Thirty-five patients (4.3%) had primary dengue infection (AgNS1 + and / or IgM + with negative IgG) and seven hundred seventy-six (776) patients (95.7%) had secondary dengue infection. 245 patients (30.2%) experienced severe signs. Renal failure (13.1%) was the main sign of severity, followed by severe bleeding (10.6%). In univariate analysis, severe bleeding were associated with primary dengue infection (OR = 2.65, 95%IC: 1.16 -6.03, p = 0.01). Twenty-four deaths (9.8%) were reported during the period. Conclusion Signs of gravity can occur during primary dengue fever. This study highlight the need to conduct more studies on the severity factors of dengue fever.
Group-ICA with Functional Connectivity During Inhibition Control in Young Adults With Autistic-like Traits: an fMRI Study of a Stop-Signal Task
Authors: Yu Yaxu , He Li , jiang qiu 
Published: November 2020

Abstract
BackgroundFew studies explored response inhibition in autistic-like traits people, using task fMRI. In this study, we examine the functional connectivity of the brain using a stop-signal task based on fMRI among young adults with autistic-like traits and investigated their ability to achieve inhibition control.Methods29 of Chinese individuals measured with AQ. Then applied stop signal task to explore the difference in brain functional connectivity in individuals with autistic-like traits.ResultsThe results showed autistic-like traits people the longer the SSRT, the worse the inhibition ability. And we used networks obtained from groupICA analysis at the functional connectivity analysis level, the SN had a negative connection with left SMG; the DAN had a negative connection with left LG; the FPN had a positive connection with left PCG; the LN had a positive connection with vermis 4 5 and negative connection with left ITG. Furthermore, the SMG, LG, PCG, and temporal gyrus were also obtained in ROI-to-ROI analysis.LimitationsOur sample size smaller, still need to multicenter, large sample confirmed this conclusion. We want to use more task paradigms to explore inhibition control in autistic-like traits people.Conclusions﻿We found that autistic-like traits people had atypical functional connectivity within brain networks in the SN, DAN, FPN, and LN, and had atypical brain areas centered on the SMG, LG, PCG, and temporal gyrus. And also highlight the importance of considering executive control function of whole-brain functional connections to better characterize brain connectivity in young adults with autistic-like traits.
Transcriptome-(Phospho)proteome Characterization of the Brain of a Constitutional Model of Cytoplasmic-predominant Pten Expression With Autism-Like Phenotypes
Authors: Thacker Stetson , Eng Charis 
Published: November 2020

Abstract
BackgroundPTEN, a well-studied tumor suppressor, has one of the strongest Mendelian associations with autism spectrum disorder (ASD), representing a special case in autism’s complex genetic architecture. Animal modeling for constitutional Pten mutation creates an opportunity to study how disruption of Pten affects neurobiology, providing insights that may be generalizable or at least inform our understanding of ASD. Although the neural transcriptome has been well characterized in Pten models, little has been done concerning the proteome and phosphoproteome. This is a critical gap in knowledge given that these –omic landscapes are more proximal to the actively observed biology than the transcriptome.MethodsWe sought to comprehensively characterize the neural proteome and phosphoproteome of the Ptenm3m4/m3m4 mouse, which exhibits cytoplasmic-predominant Pten expression. Proteomic and phosphoproteomic scans of Ptenm3m4/m3m4 and wildtype mouse brain at two-weeks- (P14) and six-weeks-of-age (P40) were performed using liquid chromatography with tandem mass spectrometry technology. Following quantification of differentially expressed/phosphorylated proteins, we performed gene overlap, gene enrichment, pathway, and network analyses to identify the similarity across the various datasets and understand the affected biological landscape.ResultsWe identified numerous differentially expressed/phosphorylated proteins, finding that dysregulation was greater at P40, consistent with the prior neural transcriptome data. We found the affected biological pathways were largely related to PTEN function, neurological processes, or neuroinflammation. Although we found minimal overlap among differentially expressed transcriptome-proteome-phosphoproteome molecules between P14 and P40 brains, there was congruence amongst the affected pathways. Importantly, network analysis identified Pten and Psd-95 as predominant regulatory nodes in the proteome and phosphoproteome, respectively. Moreover, we found overlap between our differentially expressed/phosphorylated proteins and known ASD risk genes.ConclusionsDifferential expression/phosphorylation revealed by transcriptome-proteome/phosphoproteome analyses of a germline Pten mutation model point to ASD risk genes like Pten and Psd-95 as major hubs in the protein networks, highlighting their important regulatory influence. Our observations here suggest Pten and Psd-95, known interactors in biological networks in the brain, are critical to either initiation or maintenance of cellular and perhaps organismal phenotypes related to ASD. Future research should explore rescuing Pten and Psd-95 function in attempts to ameliorate neurological pathologies and behavioral abnormalities.
Clinical Risk Factors for Mortality Among Critically ill Mexican Patients With COVID-19
Authors: Hernández-Cárdenas Carmen , Choreño-Parra José Alberto , Torruco-Sotelo Carlos , Jurado Felipe , Serna-Secundino Héctor , Aguilar Cristina , García-Olazarán José G. , Hernández-García Diana , Choreño-Parra Eduardo M. , Zúñiga Joaquín , Lugo-Goytia Gustavo 
Published: November 2020

Abstract
BackgroundLittle literature exists about the experience with critically ill COVID-19 patients from Latin America, despite this is the current epicenter of the pandemic. Here, we aimed to describe the clinical characteristics and risk factors for mortality in mechanically-ventilated COVID-19 patients from Mexico. MethodsClinical data from sixty-seven consecutive, mechanically-ventilated COVID-19 patients were analyzed. Patients were grouped according to their clinical outcome (survival vs. death). Clinical risk factors for mortality were identified by machine-learning algorithms and traditional regression analyses. ResultsThe median age of study participants was 42 years and 65% were men. The most common comorbidity observed in our study was obesity (49.2%). Fever was the most frequent symptom of illness (88%), followed by dyspnea (84%), and cough (62%). Multilobe ground-glass opacities were observed in 76% of patients by thoracic CT scan. Fifty-two percent of study participants were ventilated in prone position, and 59% required cardiovascular support with norepinephrine. Furthermore, 49% of participants had a coinfection with a second pathogen. Two-thirds of COVID-19 patients developed acute kidney injury (AKIN). Thirty deaths occurred during the study (44.7%). Levels of uric acid, creatinine, bilirubin, and SOFA score, were significantly higher among deceased patients, whereas survivors showed higher PaO2/FiO2 values at admission. AKIN, uric acid, LDH, and a longitudinal increase in ventilatory ratio were associated with mortality. Baseline PaO2/FiO2 values and a longitudinal recovery of lymphocytes were protective factors against mortality.ConclusionsOur study provides reference data about the clinical phenotype and risk factors for COVID-19-assocaited mortality among mechanically-ventilated Mexican patients.
CXCL17 is a Prognostic Biomarker That Distinguishes Severe Pandemic InfluenzaA(H1N1) from COVID-19
Authors: Choreño-Parra José Alberto , Jiménez-Álvarez Luis Armando , Ramírez-Martínez Gustavo , Sandoval-Vega Montserrat , Salinas-Lara Citlaltepetl , Sánchez-Garibay Carlos , Luna-Rivero César , Hernández-Montiel Erika M. , Fernández-López Luis Alejandro , Cabrera-Cornejo María Fernanda , Choreño-Parra Eduardo M. , Cruz-Lagunas Alfredo , Domínguez Andrea , Márquez-García Eduardo , Cabello-Gutierrez Carlos , Bolaños-Morales Francina Valezka , Mena-Hernández Lourdes , Delgado-Zaldivar Diego , Rebolledo-García Daniel , Guadarrama-Ortiz Parménides , Regino-Zamarripa Nora E. , Mendoza-Milla Criselda , García-Latorre Ethel A. , Rodríguez-Reyna Tatiana Sofía , Hernández-Cárdenas Carmen M. , Khader Shabaana A. , Zlotnik Albert , Zúñiga Joaquín 
Published: November 2020

Abstract
BackgroundCXCL17 is chemotactic for myeloid cells, exhibits broad-spectrum bactericidal activity, and is expressed in mucosal tissues. This chemokine is constitutively expressed in the respiratory tract, suggesting a role for CXCL17 in lung defenses. However, little is known about the possible participation of CXCL17 during respiratory infections in humans. Here, we evaluated the role of CXCL17 as a biomarker in patients with severe pandemic influenza A(H1N1) and coronavirus disease 2019 (COVID-19). MethodsWe conducted a prospective cohort study in hospitalized patients with severe influenza A(H1N1) and COVID-19 admitted to two national reference centers in Mexico City. Peripheral blood samples were obtained on admission for determinations of the serum levels of CXCL17 by enzyme-linked immunosorbent assay (ELISA). The expression of CXCL17 in lung autopsy specimens from patients that succumbed to both diseases was assessed by immunohistochemistry (IHQ). Serum CXCL17 levels were compared between patients grouped according to their disease and clinical outcome. The diagnostic and predictive value of serum CXCL17 levels was evaluated using machine-learning algorithms and regression analyses. ResultsA total of 92 patients were enrolled in the study, from which 68 were infected with influenza and 24 had COVID-19. Their clinical characteristics were similar, although dyspnea, rhinorrhea, and sputum production were more common during influenza, whereas dry cough and vomit were more frequent among COVID-19 patients. Both diseases induced the local expression of CXCL17 in the lung. However, serum levels of CXCL17 were increased only in patients with influenza but not COVID-19. CXCL17 not only differentiates influenza from COVID-19 but serves as a prognostic biomarker associated with mortality and renal failure in influenza patients. Using cell culture assays, we also identified that human alveolar A549 cells and peripheral blood monocyte-derived macrophages produce CXCL17 after influenza A(H1N1) pdm09 virus infection. ConclusionsOur results suggest a possible role for CXCL17 in the pathogenesis of influenza A(H1N1), supporting the use of this molecule as a prognostic biomarker. Future studies on the role of CXCL17 in COVID-19 are warranted.
One-Year Mortality of Cancer Patients with an Unplanned ICU Admission: A Cohort Analysis Between 2008 and 2017 in the Netherlands
Authors: Zee Esther Nadine van der , Termorshuizen Fabian , Benoit Dominique D. , Keizer Nicolette F. de , Bakker Jan , Kompanje Erwin J.O. , Rie Wim J.R. , Epker Jelle L. 
Published: November 2020

Abstract
BackgroundOver the last decades, a decrease in short-term mortality in cancer patients admitted to the ICU has been described in literature. However, it is unclear whether this decrease also results in a decrease in long-term mortality. Therefore, we examined the 1-year mortality of cancer patients (either haematological or solid) with an unplanned ICU admission.Methods and dataAll adult patients registered in the National Intensive Care Evaluation registry with an unplanned ICU admission in the Netherlands between 2008 and 2017 were included. The primary outcome was 1-year mortality, analysed with a mixed-effects cox-proportional hazard regression. We examined the trend in mortality rates over the inclusion period. Furthermore, we compared the 1-year mortality of cancer patients to that of patients without cancer. ResultsWe included 470,305 patients: 10,401 with haematological cancer, 35,920 with solid tumours, and 423,984 without cancer. The 1-year mortality rates were 60.1%, 46.2%, and 28.3% (p<0.01), respectively. While no statistically significant trend was found (p=0.58), a visual inspection of the graph showed a slightly decreasing trend in 1-year mortality over the inclusion period. Although we found a statistical significant difference in 1-year mortality in patients with a solid tumour (p<0.01), visual inspection showed a wide variety per year. We found a decreasing trend in 1-year mortality in ICU patients without a malignancy (p<0.01). Cancer patients surviving their critical illness and hospital admission had a 30% mortality at 1 year. ConclusionThe 1-year mortality in cancer patients with an unplanned ICU admission (either haematological or solid) was significantly higher than that of patients without cancer. A visual inspection showed a slight decrease in 1-year mortality in haematological patients, while the 1-year mortality in patients with a solid tumour varied per year. After hospital discharge, a considerable part of the patients with a malignancy died within 1 year. Physicians should discuss the long-term prognosis after an ICU admission with patients and relatives in order to manage treatments and expectations. Future research should focus on identifying cancer patients who will benefit from an ICU admission.
The Effect of the Timing of Dexamethasone Administration in Patients with COVID-19 Pneumonia
Authors: Lee Hyun Woo , Park Jimyung , Lee Jung-Kyu , Park Tae Yeon , Heo Eun Young 
Published: November 2020

Abstract
Introduction: Despite the proven benefits of dexamethasone in hospitalized COVID-19 patients, the optimum time for the administration of dexamethasone is unknown. We investigated the progression of COVID-19 pneumonia based on the timing of dexamethasone administration.Methods: A single-center, retrospective cohort study based on medical record reviews was conducted between June 10 and September 21, 2020. We compared the risk of severe COVID-19, defined as the use of a high-flow nasal cannula or a mechanical ventilator, between groups that received dexamethasone either within 24 hours of hypoxemia (early dexamethasone group) or 24 hours after hypoxemia (late dexamethasone group). Hypoxemia was defined as room-air SpO2 <90%. Results: Among 59 patients treated with dexamethasone for COVID-19 pneumonia, 30 were in the early dexamethasone group and 29 were in the late dexamethasone group. There was no significant difference in baseline characteristics, the time interval from symptom onset to diagnosis or hospitalization, or the use of antiviral or antibacterial agents between the two groups. The early dexamethasone group showed a significantly lower rate of severe COVID-19 compared to the control group (75.9% vs 40.0%, P-value=0.012). Further, the early dexamethasone group showed a significantly shorter total duration of oxygen supplementation (10.45 d vs. 21.61 d, P-value=0.003) and length of stay in the hospital (19.76 d vs. 27.21 d, P-value=0.013). However, extracorporeal membrane oxygenation and in-hospital mortality rates were not significantly different between the two groups.Conclusions: Early administration of dexamethasone may prevent the progression of COVID-19 to a severe disease, without increased mortality.
Nomogram to Early Screen Multiparous Women for Preterm Birth in a Cohort Study
Authors: Traboulsi Mayssa , Talibi Zainab El Alaoui , Boussaid Abdellatif 
Published: November 2020

Abstract
Background: Preterm Birth (PTB) can negatively affect the health of mothers as well as infants. Prediction of this gynecological complication remains difficult especially in Middle and Low-Income countries because of limited access to specific tests and data collection scarcity. Multiparous women in our study presented a higher PTB prevalence compared to nulliparous women. Methods: In a cohort study from Northern Lebanon of 1996 women, 922 were multiparous presenting a PTB prevalence of 8%. We analyzed the personal, demographic, and health indicators available for this group of women. We compared 4 modified logistic regression models (up-sampling, lasso penalized regression) to develop a nomogram that can screen for preterm in multi-parous women. The models were trained and validated on different data sets.Results: The best PTB prediction of the Logistic regression model reached around 88%. This was obtained using a Logistic Regression Model trained on up-sampled datasets and LASSO (Least Absolute Shrinkage and Selection Operator) penalized. The regression coefficients of the 6 selected variables (Pre-hemorrhage, Social status, Residence, Age, BMI, and Weight gain) were used to create a nomogram to screen multiparous women for PTB risk. Conclusions: The nomogram based on readily available indicators for multiparous women reasonably predicted most of the at PTB risk women. This tool will allow physicians to screen women that represent a high risk for spontaneous preterm birth and run furthermore adequate additional tests leading to better medical surveillance that can reduce PTB incidence.
Risk Factors Associated with Infection Recurrence of Posttraumatic Osteomyelitis Treated with Ilizarov Bone Transport Technique—A Retrospective Study of 149 Cases
Authors: Ainizier Yalikun , Maimaiaili Yushan , Li WenQiang , Alimujiang Abulaiti , Ahemaitijiang Yusufu 
Published: November 2020

Abstract
Background: Post-traumatic tibial osteomyelitis is considered as complex clinical problem due to its unique characteristics such as prolonged course, multi-staged treatment and high recurrence rate. The purpose of this study is to identify and analyze the causes and risk factors associated with infection recurrence of tibial osteomyelitis treated with Ilizarov technique. Methods: From January 2011 to January 2019, a total of 149 patients with post-traumatic tibial osteomyelitis treated with Ilizarov bone transport technique were included in this study. Demographic and clinical data were collected and analyzed. Univariate analysis and logistic regression analysis were used to analyze the factors that may affect the recurrence or reinfection of post-traumatic tibial osteomyelitis after treated with Ilizarov bone transport technique.Results: All included patients were successfully followed up with an average of 37.5 month (18-78 month), among them, 17 patients (11.41%) occurred with recurrence or reinfection of tibial osteomyelitis in which 2 cases were in distraction area and 15 cases in docking site. Among them, 5 patients were treated successfully with sensitive intravenous antibiotic, the remaining 12 patients were intervened by surgical debridement or bone grafting after debridement. Univariate analysis showed that pseudomonas aeruginosa infection, bone exposure, number of previous operations (>3 times), blood transfusion during bone transport surgery, course of osteomyelitis >3 months, diabetes was associated with recurrence or reinfection of postoperative tibial osteomyelitis. According to the results of logistic regression analysis, pseudomonas aeruginosa infection, bone exposure, and the number of previous operations (>3 times) are risk factors for recurrence or reinfection of posttraumatic tibial osteomyelitis treated with Ilizarove bone transport technique, with odds ratios (OR) of 6.055, 7.413, and 1.753, respectively. Conclusion: The number of previous operations (>3 times), bone exposure, and pseudomonas aeruginosa infection are risk factors for infection recurrence of posttraumatic tibial osteomyelitis treated with Ilizarove bone transport technique.