bluuebunny/crossref_metadata_2025_split huggingface dataset:
CmVVD is involved in fruiting body development and carotenoid production and the transcriptional linkage among three blue‐light receptors in edible fungus Cordyceps militaris
Authors: Zhang Jiaojiao , Wang Fen , Yang Ying , Wang Ying , Dong Caihong 
Published: November 2019

SummaryFruiting body development and carotenoid production are light‐induced in Cordyceps militaris. Our previous studies have shown that two blue‐light receptors, CmWC‐1 and CmCRY‐DASH, regulate fruiting body development and secondary metabolism. However, the photosensory system of C. militaris remains unclear. Here, gene deletion of Cmvvd, coding for another blue‐light receptor, resulted in reduced conidiation level and significant promotion of carotenoid content. Cmvvd transcription levels at fruiting body stages were higher than at other stages, and fruiting bodies could not develop normally in ΔCmvvd strains, indicating that Cmvvd might play an important role in fruiting body development. Rhythm loops were not affected in ΔCmvvd strains but were regulated by Cmwc‐1, and the expression of the rhythm regulator gene Cmfrq was dependent on CmWC‐1. Chromatin immunoprecipitation assay confirmed that Cmvvd is the direct target of CmWC‐1 in this fungus. Our results also revealed interdependent transcriptional relationships between Cmwc‐1 and Cmvvd, and between Cmwc‐1 and Cmcry‐DASH. Cmcry‐DASH expression was affected by Cmvvd, and the function‐loss of Cmcry‐DASH might be compensated by the high transcription of Cmvvd. This is the first report of the transcriptional linkage among the three blue‐light receptors in edible fungi and will be helpful for studies of multicellular development in this fungus.
Mbp1, a component of the MluI cell cycle box‐binding complex, contributes to morphological transition and virulence in the filamentous entomopathogenic fungus Beauveria bassiana
Authors: Ding Jin‐Li , Lin Hai‐Yan , Feng Ming‐Guang , Ying Sheng‐Hua 
Published: November 2019

SummaryThe Mbp1 protein functions as a DNA‐binding protein in the MluI cell cycle box‐binding complex and plays significant roles in yeast development. In this study, an ortholog of yeast Mbp1, BbMbp1, was characterized in a filamentous insect mycopathogen, Beauveria bassiana. BbMbp1 plays an important role in morphological changes under aerial and liquid environments. On the aerial surface, BbMbp1 was indispensable for the biogenesis of conidiophores and conidiation. Under submerged conditions, the ∆BbMbp1 mutant displayed abnormal spore‐producing structures, with a dramatic decrease in blastospore yield (~95%). The virulence of the ∆BbMbp1 mutant was notably weakened, which might be due to the defect in in vivo blastospore formation in the insect. Moreover, disruption of BbMbp1 resulted in a substantial reduction in hyphal growth on cadavers. Comparative transcriptomics revealed that BbMbp1 mediated different transcriptomes during the formation processes of conidia and blastospores. Yeast one‐hybrid assays demonstrated that BbMbp1 was required for transcriptional control of a cell wall protein gene, BbCwp, and an integral membrane protein gene, BbImp that played significant roles in conidiation and blastospore formation respectively. Our results demonstrate that BbMbp1 contributes to the morphological transitions in the pathogenic and saprophytic growth of B. bassiana via different genetic pathways.
Corporate social responsibility and financial fraud: evidence from China
Authors: Liao Lin , Chen Guanting , Zheng Dengjin 
Published: November 2019

AbstractThis paper investigates the impact of corporate social responsibility (CSR) on corporate financial fraud in China. We find that CSR scores are negatively associated with fraudulent financial activities, suggesting that CSR firms are less likely to engage in financial fraud. The results also indicate that the negative relation is more significant for CSR performance than CSR disclosure. Additionally, we demonstrate that the negative effect of CSR is more pronounced for firms with voluntary CSR practices, continuous CSR engagements, financial pressure and internal control weaknesses. Overall, we find that CSR is an ethical behaviour that reduces financial misconduct.
Voluntary stopping of eating and drinking in advance directives for adults with late‐stage dementia
Authors: Trowse Philippa 
Published: November 2019

AbstractObjectiveThe objective of this paper is to explore the ethical and legal validity of advance directives that request the voluntary stopping of eating and drinking against a backdrop of late‐stage dementia.MethodDoctrinal research and analysis of primary and secondary materials including Australian legislation, Australian case law and journal articles was undertaken.ResultsThere is legal uncertainty in Australia around whether an advance directive to voluntarily stop eating and drinking will be followed should the adult become incompetent.ConclusionVoluntary stopping of eating and drinking should be viewed in law as a form of “treatment” that competent adults can nominate in advance directives, thereby providing dementia patients with the opportunity to choose in advance, if they wish, to end their life legally, with dignity and comfort, and in a manner that does not implicate others in criminal behaviour such as assisted suicide, acceleration of death or euthanasia.
Sharp bounds on the relative treatment effect for ordinal outcomes
Authors: Lu Jiannan , Zhang Yunshu , Ding Peng 
Published: November 2019

AbstractFor ordinal outcomes, the average treatment effect is often ill‐defined and hard to interpret. Echoing Agresti and Kateri, we argue that the relative treatment effect can be a useful measure, especially for ordinal outcomes, which is defined as , with and being the potential outcomes of unit under treatment and control, respectively. Given the marginal distributions of the potential outcomes, we derive the sharp bounds on which are identifiable parameters based on the observed data. Agresti and Kateri focused on modeling strategies under the assumption of independent potential outcomes, but we allow for arbitrary dependence.
Quantifying contributions to tournament catches among resident, stocked and hybrid black basses (Micropterus spp.)
Authors: Hargrove John S. , Rogers Mark W. , Kacmar Phillip T. 
Published: November 2019

AbstractMillions of Florida bass, Micropterus floridanus Lesueur, are stocked annually into populations of largemouth bass, Micropterus salmoides Lacepède, to increase trophy fish abundance. However, little effort has related the role that resultant hybrids make to angler catches. Largemouth bass were sampled from an important recreational fishery subject to extensive Florida bass stocking to address the hypothesis that anglers capture Florida bass, largemouth bass and hybrids at rates equivalent to their overall abundance in the population. Fin clips obtained from tournament angling events (n = 348) and boat‐mounted electrofishing sampling (n = 219) were screened at 38 species‐diagnostic markers and individuals were assigned to genealogical classes using Bayesian clustering algorithms. No significant differences were identified between angler and electrofishing catches providing evidence that hybridised individuals stemming from a long‐term stocking programme may constitute an important contribution to tournament angling catch.
Migration among East and Southeast Asian Economies
Authors: Fong Eric , Shibuya Kumiko , Chen Xi 
Published: November 2019

AbstractConventional studies focus on why migration occurs between a particular pair of places. Our study asks a different question: what characteristics of the origin and destination places can explain migration flows between any two places in a region. Our study explores how economic, political, and geographic factors influence bilateral migration flows within a region in which various countries are increasingly being integrated into the regional as well as into the global economy. Drawing from diverse data sources, we explore migration flows among various economies in East and Southeast Asia between 2000 and 2005 and 2005 and 2010. Our analyses yielded two major findings. First, the relationship between economic factors and the volume of migration flows depends on the overall economy in the region. Second, the findings reveal a consistently robust and significant relationship between geographic proximity and migration flow. Implications of these findings are discussed.
How Many Parents Should There Be in a Family?
Authors: Grill Kalle 
Published: November 2019

AbstractIn this article, I challenge the widespread presumption that a child should have exactly two parents. I consider the pros and cons of various numbers of parents for the people most directly affected – the children themselves and their parents. The number of parents, as well as the ratio of parents to children, may have an impact on what resources are available, what relationships can develop between parents and children, what level of conflict can be expected in the family, as well as the costs involved in parenting and the experience of parenting a child. Indirectly, there is also an effect on who will have the opportunity to be a parent, as well as on wider social issues that I mention but do not discuss. Having considered all these factors, I conclude that there is some reason to believe that three or more parents is usually better than one or two, especially if children are to have siblings, which is typically beneficial. However, these reasons are not strong enough to support a general presumption in favor of any particular number. We should therefore jettison the two‐parent presumption and make different numbers of parents more socially accepted as well as legally possible.
Plantaricin bacteriocins: As safe alternative antimicrobial peptides in food preservation—A review
Authors: Abdulhussain Kareem Raghda , Razavi Seyed Hadi 
Published: November 2019

AbstractMany peptides are excreted by gram‐positive (+) and gram‐negative (−) bacteria, possessing antimicrobial properties, called bacteriocins. Common bacterial species produce bacteriocins are called lactic acid bacteria. Nowadays, plantaricins are natural antimicrobial peptides produced byLactobacillus plantarumstrains have obtained special attention. TheL. plantarumand their bacteriocins have got great importance in different areas as food biopreservatives and/or starters in dairy products, meat products, and fish products also, were used for treating diseases caused by pathogenic bacteria that is, reducing symptoms of irritable bowel syndrome disease (IBS) and decreasing the number of colonies of pathogenic bacteria in the wound‐burning model in mice. Moreover, plantaricins have got a potent protective role against urinary tract infection (UTI). Although there are many studies on the types of bacteriocins and their purification and uses, such as Nisin and Pediocin, there have been no reports in the literature on the characterizations, production, and purification of plantaricins. The present review aims to describe plantaricins and some of their features and applications in general. Also mentioned are the most common methods of isolation and purification.
Evaluation of the Interaction Model of Client Health Behavior‐based multifaceted intervention on patient activation and osteoarthritis symptoms
Authors: Ahn Yang Heui , Ham Ok Kyung 
Published: November 2019

AbstractPurposeThis study evaluated a multifaceted intervention for osteoarthritis symptoms.MethodsA cluster randomized controlled trial was conducted with a convenience sample of 90 patients aged between 45 and 82 years, who were recruited from three Community Health Posts (CHPs). The CHPs were randomized into two experimental groups (E1 and E2) and one control group (C). The intervention included health education and counseling combined with exercise classes based on the Interaction Model of Client Health Behavior. Trained community health nurse practitioners led the intervention. Stretching exercise (E1) and walking (E2) combined with muscle strengthening exercise were provided. The instruments included the Patient Activation Measure (PAM), Korean version of the Western Ontario and McMaster Universities Osteoarthritis Index (K‐WOMAC), Stanford Health Assessment Questionnaire Disability Scale (HAQDS), and Center for Epidemiologic Studies Depression Scale (CES‐D). The HAQDS was measured using an ordinal scale, and Likert scales were used for the other instruments. Chi‐square test and analysis of covariance were used;Pvalues <.05 were considered significant. The study was conducted in 2014.ResultsThe groups were similar at the baseline (P> .05) except for joint pain and patient activation (P< .05). At post‐test, the changes in the mean scores were significant for joint pain and stiffness, and physical functioning. E2 with walking exercise showed better improvements in joint pain and physical functioning than the other groups (P< .01).ConclusionsEight sessions of multifaceted intervention improved the osteoarthritis symptoms. Follow‐up studies will be needed to determine the intermediate and long‐term effects of the multifaceted intervention.
Therapeutic effects of Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma on doxorubicin-induced chronic heart failure in rats based on an integrated approach
Authors: Wen Jian-Xia , Li Rui-Sheng , Wang Jian , Hao Jun-Jie , Qin Wei-Han , Yang Tao , Wang Rui-Lin , Wei Shi-Zhang , Liu Xiao-Yi , Li Hao-Tian , Wang Jia-Bo , Liu Hong-Hong , Zhao Yan-Ling 
Published: November 2019

Abstract

Objectives
This study was aimed to explore the mechanism of Aconiti Lateralis Radix Praeparata (ALRP) and Zingiberis Rhizoma (ZR) on doxorubicin (DOX)-induced chronic heart failure (CHF) in rats by integrated approaches.

Methods
Effects of ALRP and ZR on cardiac function, serum biochemical indicators and histopathology in rats were analysed. Moreover, UHPLC-Q-TOF/MS was performed to identify the potential metabolites affecting the pathological process of CHF. Metabolomics and network pharmacology analyses were conducted to illustrate the possible pathways and network in CHF treatment. The predicted gene expression levels in heart tissue were verified and assessed by RT-PCR.

Key findings
ALRP-ZR demonstrated remarkable promotion of hemodynamic indices and alleviated histological damage of heart tissue. Metabolomics analyses showed that the therapeutic effect of ALRP and ZR is mainly associated with the regulation of eight metabolites and ten pathways, which may be responsible for the therapeutic efficacy of ALRP-ZR. Moreover, the results of RT-PCR showed that ALRP-ZR could substantially increase the expression level of energy metabolism-related genes, including PPARδ, PPARγ, Lpl, Scd, Fasn and Pla2g2e.

Conclusions
The results highlighted the role of ALRP-ZR in the treatment of CHF by influencing the metabolites related to energy metabolism pathway via metabolomics and network pharmacology analyses.
Dehydrodiconiferyl alcohol from Silybum marianum (L.) Gaertn accelerates wound healing via inactivating NF-κB pathways in macrophages
Authors: Hu Xu , Qin Ningbo , Xue Jingjing , Li Siqi , Huang Xiaofang , Sun Jianan , Xu Fanxing , Li Zhanlin , Li Dahong , Hua Huiming 
Published: November 2019

Abstract

Objectives
The aim of this study was to investigate the molecular mechanisms of the efficacy of lignin compound dehydrodiconiferyl alcohol (DHCA) isolated from Silybum marianum (L.) Gaertn in improving wound healing. These findings preliminarily brought to light the promising therapeutic potential of DHCA in skin wound healing.

Methods
First, the effect of DHCA on healing in vivo was studied using a full-thickness scalp wound model of mice by topical administration. Histopathological examinations were then conducted by haematoxylin and eosin (H&E), Masson’s trichrome staining and the immunofluorescence assay. Second, we further examined the anti-inflammatory mechanism of DHCA in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages by immunofluorescence assay and Western blot analysis.

Key findings
DHCA could promote scalp wound healing in mice by enhancing epithelial cell proliferation and collagen formation and reducing inflammatory cells infiltration. Moreover, the NF-κB nuclear translocation was suppressed remarkably by DHCA administration in connective tissue of healing area. DHCA was also shown to inhibit production of nitric oxide (NO) and interleukin (IL)-1β with downregulated inducible nitric oxide synthase (iNOS) expression in LPS-induced RAW 246.7 cells. More importantly, DHCA administration upregulated p-IκBα expression and induced nuclear translocation of NF-κB without affecting its expression.

Conclusions
Our study indicated that DHCA exerted anti-inflammatory activity through inactivation of NF-κB pathways in macrophages and subsequently improved wound healing.
Examining the Impact of Religious Initiation Rites on Religiosity and Disaffiliation over Time
Authors: Perry Samuel L. , Longest Kyle C. 
Published: November 2019

AbstractEarly religion scholars stressed the importance of institutionalized “rites of passage” to integrate and reinvigorate groups themselves. Surprisingly, little work, however, has explored the efficacy of such rites for the religious lives of individuals. Although research has examined the transformative role of semi‐institutionalized rites like short‐term mission trips and pilgrimages, we shift the focus to consider the potential influence of more fundamental initiation rites such as baptism, first communion, and bar/bat mitzvahs. Utilizing surveys 1 and 4 of the National Study of Youth and Religion and focusing on overall religiosity and disaffiliation as the outcomes, we examine whether experiencing a religious rite of passage during or before one's teenage years predicts the religious outcomes of young adults. We find no difference in religiosity over time between persons who experienced a religious rite passage and those who did not. However, those who underwent a religious rite of passage were 30 percent less likely to disaffiliate between data collection points. Tests for interactions show that the influence of such initiation rites does not vary across religious traditions. Findings suggest the experience of baptism, bar/bat mitzvah, confirmation, or other rites of passage matter primarily as durable markers of social identity, binding adherents to their faith community, if only nominally.
Assessing the acceptability and efficacy of teens taking charge: Transplant—A pilot randomized control trial
Authors: Korus Moira , Cruchley Elizabeth , Calic Masa , Gold Anna , Anthony Samantha J. , Parekh Rulan S. , Stinson Jennifer N. 
Published: November 2019

AbstractBackgroundAdolescents who have undergone SOT are at heightened risk for graft failure. This pilot randomized controlled trial aimed to determine the feasibility and obtain preliminary estimates of efficacy of the online TTC program.MethodsTTC is a web‐based self‐management program for adolescent SOT patients. Participants—kidney or liver transplant candidates or recipients—were enrolled over a 2‐year period and randomized to either an intervention group that accessed TTC or a control group that did not access the program. Outcome measures included feasibility, how much the program was utilized, and pre‐ and post‐intervention health‐related outcomes evaluating self‐management, self‐efficacy, mood, use of healthcare services, and knowledge. Semi‐structured interviews were conducted with participants post‐intervention.ResultsForty‐two participants were enrolled in the study. Participants in the intervention group expressed that they enjoyed learning about other teens’ experiences, but reported barriers to accessing the site, such as being too busy, computer being too slow, and not being able to access the site on their mobile device. Time spent using the website was low for the majority of participants. Patients less than 1‐year post‐transplant accessed TTC more than patients who had their transplant for longer. No significant differences were found for health‐related outcomes between groups.ConclusionsNo differences in health‐related outcomes were found between groups. Further studies that examine barriers to engagement with web‐based education tools are warranted.
Long‐Circulating Prostate‐Specific Membrane Antigen‐Targeted NIR Phototheranostic Agent
Authors: Overchuk Marta , Damen Martha P.F. , Harmatys Kara M. , Pomper Martin G. , Chen Juan , Zheng Gang 
Published: November 2019

AbstractTargeted photodynamic therapy (PDT) combined with image‐guided surgical resection is a promising strategy for precision cancer treatment. Prostate‐specific membrane antigen (PSMA) is an attractive target due to its pronounced overexpression in a variety of tumors, most notably in prostate cancer. Recently, we reported a pyropheophorbide‐based PSMA‐targeted agent, which exhibited long plasma circulation time and effective tumor accumulation. To further advance PSMA‐targeted photodynamic therapy by harvesting tissue‐penetrating properties of the NIR light, we developed a bacteriochlorophyll‐based PSMA‐targeted photosensitizer (BPP), consisting of three building blocks: (1) a PSMA‐affinity ligand, (2) a peptide linker to prolong plasma circulation time and (3) a bacteriochlorophyll photosensitizer for NIR fluorescence imaging and photodynamic therapy (Qy absorption maximum at 750 nm). BPP exhibited excellent PSMA‐targeting selectivity in both subcutaneous and orthotopic mouse models. The nine D‐peptide linker in BPP structure prolonged its plasma circulation time (12.65 h). Favorable pharmacokinetic properties combined with excellent targeting selectivity enabled effective BPP tumor accumulation, which led to effective PDT in a subcutaneous prostate adenocarcinoma mouse model. Overall, bright NIR fluorescence of BPP enables effective image guidance for surgical resection, while the combination of its targeting capabilities and PDT activity allows for potent and precise image‐guided photodynamic treatment of PSMA‐expressing tumors.
Effects of cultural institutes on bilateral trade and FDI flows: Cultural diplomacy or economic altruism?
Authors: Demir Firat , Im Hyeonjin 
Published: November 2019

AbstractThe number of cultural institutes from major developed and developing countries increased significantly in the last twenty years. In this paper, using cross‐sectional and panel data analysis on bilateral trade in goods and services, and FDI inflows and outflows, we examine the economic effects of 1,266 cultural institutes from China, France, Germany, Japan, Portugal, Spain, Turkey and UK for the period of 1990–2015. The empirical results suggest that cultural institutes have significantly positive trade and FDI enhancing effects, which are persistent over time. However, these effects are most robust only with goods exports and FDI outflows. Furthermore, the economic effects of cultural institutes are not homogenous across destinations and are the strongest for developed rather than developing host countries. There is also significant heterogeneity among cultural institutes with significant differences in their economic effects on different types of bilateral trade and FDI flows.