bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Atellica COAG 360 coagulation analyzer in a central laboratory of a maximum care hospital
Authors: Hörber Sebastian , Lehmann Rainer , Peter Andreas 
Published: November 2019

AbstractIntroductionFully‐automated coagulation analyzers are key components of a high‐throughput central laboratory. The novel Atellica COAG 360 (Siemens Healthineers) is a high‐volume coagulation analyzer approved for hemostasis diagnostics. The aim of the study was to evaluate the analytical performance of this coagulation analyzer in a central laboratory.MethodsIntra (n = 10)‐ and inter (n = 20)‐assay precision of the Atellica COAG 360 was determined using commercially available control samples. Patient samples (n = 74‐104) were used for comparison analyses with the Sysmex CS‐5100 (Siemens Healthineers). Effects of visual interferences on coagulation testing were assessed and the sample throughput rate of the Atellica COAG 360 was determined.ResultsIntra‐ and inter‐assay precision of the Atellica COAG 360 showed coefficient of variations (CVs) < 5% for most of the coagulation parameters comparable to CVs of the Sysmex CS‐5100. Passing‐Bablok and Bland‐Altman analyses revealed high correlation and good agreement between both coagulation analyzers in determination of coagulation parameters. Results of coagulation measurements determined in optically abnormal samples were comparable between the Atellica COAG 360 and the Sysmex CS‐5100 and were confirmed by mechanical measurements on a STart Max (Stago Diagnostics) coagulation analyzer. A sample throughput rate of about 190 tests per hour in a routine setting including five coagulation parameters was determined for the Atellica COAG 360 integrated in a total laboratory automation system.ConclusionThe Atellica COAG 360 provides high analytical performance as high‐throughput analyzer for routine and specific coagulation parameters and is suitable to be connected to a total laboratory automation.
Creating Spaces for Reflection with Digital Autoethnography: Students as Researchers into Their Own Practices
Authors: Neil Joanna 
Published: November 2019

AbstractThis article discusses how digital technologies give students agency in creating new spaces for their reflective activity. Undergraduate art and design students from across fine art, textiles, fashion, interiors, graphics and illustration and animation degree programmes experimented with digital tools, platforms and social media to document and examine their own making. The research took place at a further education college with externally validated higher education provision in the North West of England. Thirteen students signed up as research participants and shared blogs and documentation, had tutorials recorded and completed in‐depth interviews. The research project investigated how and what technologies students used and whether their use stimulated in‐depth reflection on their art and design practices and developing professional identities. This student‐led pedagogy evidences an inclusive approach where they used autoethnography to support themselves as researchers into their own practices; the methodology became a strategy for critical and dialogic reflection. Participants took part in several unstructured interviews providing a wealth of rich phenomenological data. Thematic analysis as defined by Braun & Clarke (2006), was used as a method to analyse and identify patterns of experience, interpretations and descriptions across the data set, enabling me to see and make sense of these collective and shared meanings.
The 6Rs: Inclusive Creative Methodology for Design Research
Authors: White Tanya 
Published: November 2019

AbstractIn fashion design, pedagogy balancing a strong technical foundation with a more disruptive attitude during the ideation and development procedures provides the potential for diverse, emergent, aesthetically and critically poignant outputs. The ultimate goal in this is to offer a learning environment that is inclusive and accesses dormant design curiosity, also, as a teacher, to devise methods that will lead to discovering a personal and distinct aesthetic vocabulary. ‘Ratio’, ‘resize’, ‘repeat’, ‘reduce’, ‘remix’ and ‘rearrange’ are the 6Rs that can challenge the creative design process and reprogramme the design brain into unearthing radical new forms, concepts and aesthetics. This article will address the established literature on the ways of nurturing creative thinking as it supports the methodology of serious play directed by the 6R terms to exercise ideation generation in fashion education. This discussion will be evidenced with a case study to show that the 6Rs can successfully introduce and/or expand creative thinking in fashion design processes. The aim of this is to provide students with tools, habits and tasks that empower a creative mindset when approaching the early conceptual and compositional stages of garment development, while also addressing the tutor’s role in establishing and exemplifying a creative ethos that is integral to initiating these methods and pedagogy. Most importantly, this approach is fundamentally driven by the need to invest in a more diverse student body to potentially reach unnoticed and less privileged fashion talent.
Anton Ehrenzweig, the Artist Teacher and a Psychoanalytic Approach to School Art Education
Authors: Walton Neil 
Published: November 2019

AbstractIn the 1960s Anton Ehrenzweig devised an experimental course for school art teachers based on his deep knowledge of British psychoanalytic theory, especially Melanie Klein’s ideas of projection and introjection. Ehrenzweig’s early advocacy for the idea of an artist teacher, which formed a key element of his Art Teachers Certificate course at Goldsmiths, could be seen as ahead of its time, anticipating some of the ideas and practices of the past couple of decades. However, his claim that good teachers use their pupils as a medium for the teacher’s own creativity raises ethical questions that still resonate today. In this article, I will draw out some comparisons between Ehrenzweig’s theories of creativity and art education, and recent writing on the artist teacher. I will consider ways in which Ehrenzweig’s development of Kleinian psychoanalytic theory can both complement and challenge current thinking about the merging and differentiation of artist, teacher and student identities.
Developing Place‐Based Pedagogies to Challenge Institutional Authority
Authors: Riding Deborah , Talbot‐Landers Catherine , Grimshaw Nichola , O’Keeffe Helen 
Published: November 2019

AbstractThis article discusses a current research project being undertaken by Tate Liverpool with a local university. The study is exploring the impact of a school‐in‐residence programme on children, teachers and the gallery. The invitation to schools to undertake these residencies fits with current agendas within the museum and galleries sector where institutions internationally have increasing ambitions towards handing over to their audiences, encouraging them to take ownership of their physical and intellectual spaces. However, the power dynamics at play, in terms of who makes the invitation and on what terms, have ethical implications that make taking up this offer challenging and potentially limiting. This article will begin to explore the possibilities of Place‐Based Education and its pedagogy as a practice to challenge these positions for both the teacher and gallery.
How mothers feel: Validation of a measure of maternal mood
Authors: Savage McGlynn Emily , Martin Colin R. , Redshaw Maggie 
Published: November 2019

AbstractRationaleLow mood may affect developing relationships with a new baby, partner and family. Early identification of mood disturbance is crucial to improve outcomes for women perinatally. Instruments such as the Edinburgh Postnatal Depression Scale (EPDS) are used routinely, with evidence that some women do not feel comfortable with how they are asked about their mental health.ObjectiveTo develop a mood checklist as a user‐friendly, effective measure of well‐being in post‐partum women, for use by health professionals.MethodsCognitive interviews with women who had recently given birth assessed response format and face validity of a prototype measure. A cross‐sectional survey followed. A random split‐half instrument development protocol was used. Exploratory factor analysis determined factor structure with the first sample,. The second sample confirmed factor structure and evaluationof key psychometric variables and known‐groups discriminant validity (KGDV), requiring a supplementary between‐subjects design with stratification based on case negative/case positive classification using EPDSscreening cut‐off criteria.ResultsCognitive interview data confirmed the face validity of the measure. Exploratory factor analysis indicated an 18 item two‐factor model with two (negatively) correlated factors. Factor 1 loaded with items reflecting positive mood and factor 2 negative items. Confirmatory factor analysis showed a good fit to the two‐factor model across the full spectrum of fit indices. Statistically significant differences between groups were observed in relation to as EPDS caseness classification. Cronbach alpha coefficients for the positive and negative subscales revealed acceptable internal consistency of 0.79 and 0.72, respectively.ConclusionThe outcome checklist may be appropriate for use in clinical practice. It demonstrated effective psychometric properties and clear cross‐validation with existing commonly used measures.
Variation in cownose ray Rhinoptera neglecta abundance and group size on the central east coast of Australia
Authors: Tagliafico Alejandro , Butcher Paul A. , Colefax Andrew P. , Clark Graeme F. , Kelaher Brendan P. 
Published: November 2019

AbstractHere, we provide baseline information about the relative abundance and group size of the Australian cownose ray Rhinoptera neglecta on the central east coast of Australia. Using drone monitoring over 2 years, we completed 293 transects, each 2 km in length, at four locations distributed along c.100 km of coast. In total, 5979 R. neglecta were observed with overall relative abundance (±SE) of, 20.4 (±3.3) individuals per transect. The numbers of R. neglecta varied among locations, with the highest density found off the beach adjacent to the river mouth at Evans Head. The number of rays observed also decreased with increasing wind speed. While some of this relationship was probably associated with visibility, R. neglecta may also move offshore during strong winds. We found no evidence that R. neglecta was under significant threat. Additionally, our cost‐effective surveys demonstrate the utility of aerial drones in fisheries conservation biology.
β‐Carotene‐fortified gari: Processing variables effect on nutritional and sensory qualities
Authors: Abano Ernest E. , Quayson Enoch T. , Bosompem Martin , Quarm Margaret 
Published: November 2019

AbstractDifferent proportions of orange‐fleshed sweet potatoes (OFSP) were used to substitute cassava mash and fermented spontaneously to produce composite gari—a gritty‐crispy ready‐to‐eat food product. Both the amount of OFSP and the fermentation duration (FD) caused significant increases in the β‐carotene content of the composite gari. OFSP addition reduced the luminance while roasting made the composite gari yellower when compared with the cake used. Addition of OFSP negatively affected the swelling capacity of the gari although not significant. The taste, texture, flavor, and the overall preferences for the composite gari decreased due to the addition of the OFSP but FD improved them. The sample with 10% OFSP and FD of 1.81 days was found to produce the optimal gari. One portion of the optimal gari would contribute to 34.75, 23.2, 23.2, 27, 17, and 16% of vitamin A requirements among children, adolescent, adult males, adult females, pregnant women, and lactating mothers, respectively. The study demonstrated that partial substitution of cassava with OFSP for gari production would have the potential to fight the high prevalence rate of vitamin A deficiency among less developed regions of Africa.Practical applicationsGari is a major staple for Ghanaians and people in the West African subregion due to its affordability and swelling capacity. It is mainly eaten raw with water, sugar, groundnut, and milk as gari‐soakings or with hot water to prepare gelatinized food called gari‐kai in Ghana or “eba” among Nigerians. However, gari is limited in β‐carotene, a precursor of vitamin A. Orange‐fleshed sweet potato (OFSP) is known to contain a large amount of β‐carotene, a vitamin A precursor. There is severe clinical vitamin A deficiency (VAD) prevalence among Ghanaians and many African countries. Therefore, addition of OFSP to gari would have the potential to fight the high prevalence rate of VAD among less developed regions of Africa.
Living in one's own world, while life goes on: Patients' experiences prior to a kidney transplantation with a living donor
Authors: Kristensen Ingrid V. , Birkelund Regner , Henriksen Jette , Agerskov Hanne , Norlyk Annelise 
Published: November 2019

AbstractAims and objectivesTo investigate patients' existential experiences in everyday life prior to a kidney transplantation with a living donor.BackgroundKidney transplantation is a well‐established treatment for patients with end‐stage kidney disease. The prevalence of patients living with end‐stage renal disease is increasing. Simultaneously, kidney transplantations with a living donor are increasing. However, patients experience challenging existential aspects concerning kidney transplantation.DesignA qualitative study with a hermeneutic‐phenomenological approach inspired by Ricoeur was chosen.MethodsFourteen interviews with patients living with end‐stage kidney disease were conducted 7–14 days before a planned kidney transplantation with a living donor. Analysis and interpretation were based on Ricoeur's theory of interpretation. We applied the Criteria for Reporting Qualitative Research (see Appendix S1).ResultsFour themes were identified: living with subjective feelings of illness while objectifying the body; living in one's own world while the world outside goes on; feeling grateful while being concerned for the donor; and hoping for the best, while preparing for the worst.ConclusionPatients' existential challenges are multifaceted. Patients articulate their kidney function in numeric terms, trying to make the invisible visible for themselves and others. Sustaining normality becomes important for patients, and the waiting time from donor evaluation to transplantation triggers excitement, hope and frustration.Relevance to clinical practiceThe results increase insights into individuals' existential experiences in their everyday lives. Hereby, the results articulate the need for support from health professionals prior to a kidney transplantation.
Situational awareness in the outpatient encounter between patients with breast cancer or malignant melanoma and healthcare professionals: Patients’ perceptions
Authors: Jørgensen Lone , Kastrup Jensen Susanne , Brogaard Bettina 
Published: November 2019

AbstractAims and objectivesTo explore patients’ experiences of situational awareness in the outpatient encounter when they are informed about the diagnosis of breast cancer or malignant melanoma.BackgroundPatients enter a stressful situation when receiving a diagnosis of breast cancer or malignant melanoma, and research indicates that needs are most prominent at this time. However, healthcare professionals often fail to address these needs adequately. It is unclear how patients experience situational awareness practised to meet their fundamental needs in the encounter when they are informed about the diagnosis of cancer.DesignThis study used a phenomenological hermeneutical approach.MethodsNine semi‐structured interviews with patients being diagnosed with breast cancer or malignant melanoma were performed. The interpretation theory of Paul Ricoeur guided the analysis. The study is presented in line with the COREQ checklist.ResultsThe analysis resulted in three themes: 1) “Being accompanied” refers to how patients need information to be targeted to them as individuals. 2) “Being seen” points to HCPs’ exploration of the patients’ perspectives to get an understanding of their preferences. 3) “Being taken care of” indicates that patients feel supported if situational awareness is practised by the healthcare professionals.ConclusionPracticing situational awareness in the outpatient encounter is essential to patients’ experience of feeling accommodated or rejected. Patients feel rejected when their fundamental needs are not met while experiencing situational awareness seems to accommodate fundamental needs and pre‐empt an inappropriate patient outcome.Relevance to clinical practiceHCPs need to acknowledge the importance of using a structured approach to meeting patients’ fundamental needs in a stressful situation. Each patient is different and may experience different needs in encounters where they are receiving the diagnosis of breast cancer or malignant melanoma. Therefore, treatment and care must be tailored to the individual patient based on a caring relationship.
A single oral dose of fluralaner (Bravecto®) in dogs rapidly kills 100% of blood‐fed Phlebotomus perniciosus, a main visceral leishmaniasis vector, for at least 1 month after treatment
Authors: Bongiorno G. , Meyer L. , Evans A. , Lekouch N. , Bianchi R. , Khoury C. , Chiummo R. , Thomas E. , Gradoni L. 
Published: November 2019

AbstractDogs are the reservoir host of zoonotic visceral leishmaniasis (VL) caused by Leishmania infantum (Kinetoplastida: Trypanosomatidae). Both subclinically‐infected and sick animals can be infectious to competent phlebotomine vectors. The degree and duration of insecticidal efficacy of an oral dose of fluralaner (Bravecto®; Merck Animal Health) was determined in dogs exposed to bites of Phlebotomus perniciosus (Diptera: Psychodidae), a main Mediterranean vector of VL. Twelve dogs allocated to two groups of six animals each were included in a parallel‐group designed, negative‐controlled, randomized, blinded, single‐centre efficacy study. Group 2 was treated with fluralaner on day 0, and sand‐fly exposure of both groups was performed on days 1, 28 and 84. Viability of blood‐fed females was assessed up to 96 h after exposure and efficacy was measured as the survival rate of specimens fed on Group 2 versus those fed on Group 1. A mortality of 100% was recorded at 24 h in females fed on Group 2 at both days 1 and 28. Significant insecticidal efficacy was still observed on day 84, with > 50% mortality recorded by 48 h post blood meal in Group 2. Fluralaner treatment of dogs represents a promising and affordable method for reducing the pool of infected vectors in endemic settings of zoonotic VL.
Therapeutic Enhancement of Verteporfin‐mediated Photodynamic Therapy by mTOR Inhibitors
Authors: Kraus Daniel , Palasuberniam Pratheeba , Chen Bin 
Published: November 2019

AbstractPhotodynamic therapy (PDT) with photosensitizer verteporfin is a clinically approved vascular disrupting modality that is currently in clinical trial for cancer treatment. In this study, we evaluated PDT in combination with either mTORC1 inhibitor rapamycin or mTORC1/C2 dual inhibitor AZD2014 for therapeutic enhancement in SVEC endothelial cells. Verteporfin‐PDT alone induced cell apoptosis by activating the intrinsic apoptotic pathway. However, it increased the expression of anti‐apoptotic protein MCL‐1 and the phosphorylation of S6, a downstream molecule of mTOR signaling. In contrast, mTOR inhibitors rapamycin and AZD2014 did not induce apoptosis in SVEC cells. They suppressed MCL‐1 expression and S6 phosphorylation and imposed a potent inhibition on cell proliferation. PDT in combination with mTOR inhibitors activated the intrinsic apoptotic pathway and resulted in increased apoptosis. Combination treatments also led to sustained inhibition of cell proliferation. Although AZD2014 was more effective for cell growth inhibition and PDT enhancement than rapamycin at the higher concentrations examined in the study, both inhibitors effectively enhanced PDT response, suggesting that inhibition of mTORC1 is crucial for PDT enhancement. Our results indicate that mTOR inhibitors mechanistically cooperate with PDT for enhanced cell death and sustained growth inhibition, supporting a combination approach for therapeutic enhancement.
Patterns of Policy Integration and Administrative Coordination Reforms: A Comparative Empirical Analysis
Authors: Trein Philipp , Maggetti Martino 
Published: November 2019

AbstractDuring the last two decades, scholars have pointed to a process of “denationalization,” or the delegation of competencies away from the center of the nation‐state—upward, downward, and sideward. At the same time, scholars have observed a transformation of the central state aimed at strengthening its steering capacity by means of integrating sectoral public policies and coordinating administrative units. Little systematic comparative evidence is available regarding this second phenomenon and its relationship with denationalization. The authors contribute to this line of research by presenting a comparative analysis of cross‐sectoral reforms concerning public policies and public sector organizations, covering four policy fields in 13 countries, from 1980 to 2014. Using descriptive statistics and Bayesian change point estimation, this article shows that policy integration and administrative coordination reforms configure a powerful trend, which displays considerable variation across time, policy fields, and countries.
Does lean body mass equal health despite body mass index?
Authors: Colpitts Benjamin H. , Bouchard Danielle R. , Keshavarz Mohammad , Boudreau Jonathan , Sénéchal Martin 
Published: November 2019

ObjectiveTo determine the association between having simultaneously high body mass index (BMI) and high relative lean body mass (LBM) and cardio‐metabolic risk factors, metabolic syndrome (MetS), and diabetes in adults.Materials and MethodsA cross‐sectional analysis was performed on 4982 adults aged 19‐85 years that participated in the National Health and Nutrition Examination Survey (cycles 1999‐2000‐2005‐2006). The primary exposure variable was categorization into four groups: (a) Low‐BMI/Low‐LBM, (b) Low‐BMI/High‐LBM, (c) High‐BMI/Low‐LBM, and (d) High‐BMI/High‐LBM. LBM was assessed using dual‐energy X‐ray absorptiometry. The primary outcome measures were cardio‐metabolic risk factors, MetS based on the ATP III definition; participants were required to have at least three of the following five criteria: high waist circumference, low HDL cholesterol, elevated triglyceride levels, high resting blood pressure, and self‐reported diabetes.ResultsCompared to the High‐BMI/High‐LBM, most cardio‐metabolic risk factors were significantly different among groups (P < .05) while no such differences were observed for the High‐BMI/Low‐LBM (P > .05). Exception of waist circumference (OR [95%]: 21.8 [8.84‐53.82]), there was no increased odds of having cardio‐metabolic risk factors in the High‐BMI/Low‐LBM compared with the High‐BMI/High‐LBM (P > .05). The odds of having MetS and diabetes for the High‐BMI/Low‐LBM compared with the High‐BMI/High‐LBM were OR (95% CI): 1.68 (0.84‐3.36) and 0.59 (0.26‐1.34), respectively.ConclusionsOur results suggest that having a high‐BMI as well as high relative LBM levels is not associated with cardio‐metabolic risk factors, MetS, and diabetes. Therefore, maintaining a BMI below 30 kg/m2 appears to be clinically relevant, regardless of LBM levels.