bluuebunny/crossref_metadata_2025_split huggingface dataset:
StartReact increases probability of muscle activity and distance in severe/moderate stroke survivors during two-dimensional reaching task
Authors: Rahimi Marziye , Honeycutt Claire F. 
Published: November 2019

AbstractObjectiveStartReact elicits faster, larger, and more appropriate muscle activation in stroke survivors but has been only cursorily studied to date during multi-jointed reaching. Our objective was to evaluate StartReact on unrestricted, two-dimensional point-to-point reaching tasks post-stroke.MethodData from 23 individuals with stroke was collected during point-to-point reaching. Voluntary and StartReact trials were compared between mild, severe/moderate, and the unimpaired arm.ResultsStartReact showed an increase in probability of muscle activity, larger muscle activity amplitude and faster muscle activity onset. Despite changes in muscle activity, metrics of movement (distance, final error, linear deviation) were largely the same between StartReact and Voluntary trials except in severe/moderate stroke who had larger reaching distances during StartReact.ConclusionWhile StartReact impacted many metrics of muscle activity, the most profound effect was on probability of muscle activity increasing 34% compared to Voluntary which allowed severe/moderate subjects to increase reaching distance but did not translate to decrease in final error suggesting that the additional movement was not always directed towards the appropriate target.SignificanceThese results indicate that SR has the capacity to activate paralyzed muscle in severe/moderate patients, but future studies are needed to explore the possible use of SR in the rehabilitation.
A multivariable Mendelian randomization to appraise the pleiotropy between intelligence, education, and bipolar disorder in relation to schizophrenia
Authors: Adams Charleen D. 
Published: November 2019

AbstractEducation and intelligence are highly correlated and inversely associated with schizophrenia. Counterintuitively, education genetically associates with an increased risk for the disease. To investigate why, this study applies a multivariable Mendelian randomization of intelligence and education. For those without college degrees, older age of finishing school associates with a decreased likelihood of schizophrenia—independent of intelligence—and, hence, may be entangled with the health inequalities reflecting differences in education. A different picture is observed for schooling years inclusive of college: more years of schooling increases the likelihood of schizophrenia, whereas higher intelligence distinctly and independently decreases it. This implies the pleiotropy between years of schooling and schizophrenia is horizontal and likely confounded by a third trait influencing education. A multivariable Mendelian randomization of schooling years and bipolar disorder reveals that the increased risk of schizophrenia conferred by more schooling years is an artefact of bipolar disorder – not education.
Cell-type specificity of neuronal excitability and morphology in the central amygdala
Authors: Adke Anisha P. , Khan Aleisha , Ahn Hye-Sook , Becker Jordan J. , Wilson Torri D. , Valdivia Spring , Sugimura Yae K. , Gonzalez Santiago Martinez , Carrasquillo Yarimar 
Published: November 2019

ABSTRACTCentral amygdala (CeA) neurons expressing protein kinase C delta (PKCδ+) or Somatostatin (Som+) differentially modulate diverse behaviors. The underlying features supporting cell-type-specific function in the CeA, however, remain unknown. Using whole-cell patch-clamp electrophysiology in acute mouse brain slices and biocytin-based neuronal reconstructions, we demonstrate that neuronal morphology and relative excitability are two distinguishing features between Som+and PKCδ+CeLC neurons. Som+neurons, for example, are more excitable, compact and with more complex dendritic arborizations than PKCδ+neurons. Cell size, intrinsic membrane properties, and anatomical localization were further shown to correlate with cell-type-specific differences in excitability. Lastly, in the context of neuropathic pain, we show a shift in the excitability equilibrium between PKCδ+and Som+neurons, suggesting that imbalances in the relative output of these cells underlie maladaptive changes in behaviors. Together, our results identify fundamentally important distinguishing features of PKCδ+and Som+cells that support cell-type-specific function in the CeA.
Nuclear encoded photosynthesis genes are specifically controlled by the NuA4 complex
Authors: Bieluszewski Tomasz , Sura Weronika , Bieluszewska Anna , Kabza Michał , Abram Mateusz , Włodzimierz Piotr , Dzięgielewski Wojciech , Szymańska-Lejman Maja , Lachance Catherine , De Winne Nancy , De Jaeger Geert , Côté Jacques , Sadowski Jan , Ziolkowski Piotr A. 
Published: November 2019

AbstractNuA4, an essential histone acetyltransferase complex, is required for efficient transcription in eukaryotes. Using genome editing, genomic approaches and biochemical assays, we characterized plant homologues of two key components of this complex, EPL1 and EAF1 inArabidopsis thaliana. Surprisingly, we found that loss of AtEPL1, which is necessary for enzymatic activity of NuA4, is not lethal. Contrary to yeast, mutants lacking AtEAF1, responsible for complex targeting, display severe pleiotropic phenotype which copies that ofAtepl1.Atepl1andAteaf1mutants grow slowly, contain reduced chlorophyll levels and small chloroplasts. We provide evidence that these alterations are not caused by disturbance of GLK transcription factors, the major regulators of chloroplast development. Using ChIP-seq we show that H4 acetylation levels are dramatically reduced in the chromatin of theAtepl1mutant, while H3 acetylation remains mostly unchanged. We use our data to define NuA4-dependent genes and show that chloroplast-related genes are significantly overrepresented in this group, consistent with the pale-green phenotypes of the mutants. We propose that NuA4 was adopted in plants to control nuclear-encoded photosynthesis genes.SignificancePhotosynthesis depends on chloroplast proteins, most of which are nucleus-encoded and thus subject to control mechanisms common across eukaryotes. Here we show that NuA4, an evolutionary conserved transcriptional coactivator, is necessary for proper development of photosynthetic apparatus. Surprisingly, in contrast to yeast and metazoans, plants engineered to lack core NuA4 subunits are capable of vegetative development despite dramatic genome-wide loss of NuA4-dependent H4K5 acetylation. This chromatin perturbation seems to directly affect 350 genes which, in addition to reduced H4K5ac levels, display decreased transcript levels but no loss of transcription-related H3K9ac. A significant proportion of these genes are related to chloroplast function, particularly to translation, an intriguing parallel to the yeast NuA4’s role in transcription of ribosome biogenesis-related genes.
Assessing the effects of agricultural intensification on natural habitats and biodiversity in Southern Amazonia
Authors: Göpel Jan , Schüngel Jan , Schaldach Rüdiger , Stuch Benjamin , Löbelt Norman 
Published: November 2019

AbstractThe ongoing trend toward agricultural intensification in Latin America makes it essential to explore intensification measures in combination with assumptions regarding future socio-economic development and policies to protect biodiversity and natural habitats. Information on the future development of land-use and land-cover change (LULCC) under the combination of various driving factors operating at different spatial scale-levels, e.g., local land-use policy and global demands for agricultural commodities is required. The spatially explicit land-use change model LandSHIFT was applied to calculate a set of high-resolution land-use change scenarios for Southern Amazonia. The time frame of the analysis is 2010 - 2030. The resulting maps were analyzed in combination with spatially explicit maps depicting vertebrate species diversity in order to examine the effect of a loss of natural habitats on species ranges as well as the overall LULCC-induced effect on vertebrate diversity as expressed by the Biodiversity Intactness Index in this region. The results of this study indicate a general decrease in Biodiversity Intactness in all investigated scenarios. However, agricultural intensification combined with diversified environmental protection policies show least impact of LULCC on vertebrate species richness and conservation of natural habitats compared to scenarios with low agricultural intensification or scenarios with less effective conservation policies.
Redefining economics: why shared value is not enough
Authors: Glauner Friedrich 
Published: November 2019

Purpose
This paper aims to offer scholars and practitioners critical arguments on the strengths and weaknesses of the shared value concept and of the mental model of economics that lies at its heart. On the basis of these arguments, it proposes the paradigm of ethicological value-added creation as a new economic framework extending the shared value concept into a concept of lastingly viable business strategy.

Design/methodology/approach
Conceptual and philosophical analysis of the mental model of economics and of basic concepts and premises regarding scarcity, competition, growth and raising value. Application of this analysis to the re-design of the shared value approach and to the development of practical guidelines for sustainably viable business models.

Findings
This paper highlights how the shared value approach can be transformed into an even stronger strategic tool for the design of viable business models.

Practical implications
Scholars, entrepreneurs and managers receive a new conceptual framework to design lastingly viable business models on the basis of re-defined tools and concepts.

Originality/value
Leading texts on strategy and business development as well as CSR-driven texts on designing sustainable business models do not bridge the paradox of destructive wealth creation, i.e. the fact that individually rational and, in itself, highly successful economic behaviors lead, on the group level and the level of the whole system, to an outcome that by and large is highly destructive, as it places the social, ecological and economic sources of this wealth creation process in existential jeopardy. The paper proposes a new framework of economic reasoning for solving the paradoxes that shape current economic models and the shared value approach. It offers a first set of indicators, the parameters by which the shared value approach can be transformed into a living model for generating resource growth and added value creation cycles that stop the present downward spiral of acceleration, disruption, concentration and resource depletion. The paper thus presents forms of shared value creation that are more holistic and sustainable.
The effects of coopetition on the innovation activities and firm performance
Authors: Fernandes Cristina I. , Ferreira João J. , Veiga Pedro M. , Marques Carla 
Published: November 2019

PurposeThe purpose of this paper involves evaluating the impact of coopetition on the innovation activities and innovation performance of companies.Design/methodology/approachThe study deployed data from the Community Innovation Survey – CIS 2012 and subject to the application of different multivariate statistical analysis processes.FindingsThe authors furthermore conclude that coopetition and the transfer of knowledge to and from competitors generates a statistically significant positive impact on company innovation-related activities and performance.Originality/valueThis work enriches the theory of innovation from the perspectives of game-theoretic strategic and resource theory approach. Moreover, the findings provide several recommendations for managers to effectively conduct firm’s coopetition strategy on innovation performance.
The “Too Hard Basket”: managing workplace bullying
Authors: Lockhart Pamela , Bhanugopan Ramudu 
Published: November 2019

Purpose
The purpose of this paper is to examine the use of employee assistance programs (EAP) as a form of perceived organisational support (POS) to address workplace bullying (WB), from the perspective of employees who have been the victims of bullying.

Design/methodology/approach
Using an on-line survey, data were collected from 397 employees across a range of positions and industry sectors in Australia, who indicated they had been subjected to bullying.

Findings
The results of the study indicate that WB is rife, and although anti-bullying policies were in existence participants felt that these were mere tokenism. The level of POS and use of EAPs were considered to be inadequate and, interestingly, in some cases offered more support to the bully than the victim.

Research limitations/implications
With the increased rate of WB, organisations are seeking different ways to address this. This study highlights that the ability of EAPs to provide support to employees in these circumstances appears to be limited. The findings suggest that if management wish to use EAPs to support employees in cases of WB, they must invest more in them.

Originality/value
This study seeks to extend research into the management of WB through EAPs and POS and posits that there is a high level of dissatisfaction with management’s response and support with regard to bullying incidents.
Exploring forensic service users’ experience of participating in a community life skills and work-readiness programme
Authors: McKenzie Chloe , Tarpey Emma 
Published: November 2019

Purpose
The purpose of this paper is to provide insight into the experiences of individuals with a criminal history of participating in a community life skills and work-readiness programme.

Design/methodology/approach
Semi-structured interviews were conducted with seven individuals that have a criminal history who were participating, or had previously participated, in a community life skills and work-readiness programme. This data was analysed by interpretative phenomenological analysis.

Findings
Four superordinate themes emerged, these were: “need to change”, “changing identity”, “giving back to the community” and “a sense of belonging”. These themes are discussed in relation to desistance literature and the Good Lives Model.

Practical implications
This research identifies through the participants’ narratives that engaging with the programme appeared to facilitate the desistance process. The importance of community programmes that provide participants skills and social integration must be acknowledged.

Originality/value
There is limited research on the experiences of forensic services users’ experiences of community programmes, especially those that are not aimed specifically at ex-offenders. The results of this research can be used to enhance services and identify further research areas.
Traditional agri-food products as a leverage to motivate tourists
Authors: Cafiero Carlo , Palladino Monica , Marcianò Claudio , Romeo Giuseppa 
Published: November 2019

PurposeThis paper aims to provide evidence on the extent to which traditional agri-food products (TFPs) constitute a leverage to promote tourism in the province of Reggio Calabria, Italy, and discuss ways in which community-led local development governance institutions might enhance it.Design/methodology/approachThe study is based on a review of existing information on Calabrian TFPs to classify them by area of production and identify those that are specific or relatively small areas, in addition to a qualitative analysis of the content of the texts of a sample of websites promoting tourism in the region.FindingsThough food is one of the leverages used to promote tourism in Calabria, TFPs are not yet sufficiently exploited to attract tourists to the province of Reggio Calabria, in spite of their potential as a vital expression of local culture and traditions.Research limitations/implicationsThe selection of the websites used in the study may not be exhaustive of the full spectrum of Web-based promotion of tourism in Calabria.Practical implicationsThe results provide useful insights to public and private institutions responsible for rural development and tourism promotion in Calabria. The database on the TFPs of the province of Reggio Calabria permits an easy reading of the geographical distribution of the different categories of products, useful as a resource for further studies and as a local development policy support tool.Social implicationsPromoting a form of culturally sensitive, food-based tourism in the interior areas of Calabria may constitute an important factor to revert the trend towards impoverishment, migration of young people and depopulation of the interior areas of Calabria. This is a particularly sensitive issue in Italy today, in view of the difficulties that other strategies pursued in the area are facing.Originality/valueExisting literature on typical food products in Italy focuses on those labelled by denomination of origin and geographic protection. This is one of the first papers focusing on TFPs labelled asProdotti agroalimentari tradizionaliin the Italian legislation. By exploring the role of local food and traditions in promoting tourism, this paper expands the scope of existing studies of rural tourism and on rural development in Calabria, and beyond.
Impacts of social welfare system on the employment status of low-income groups in urban China
Authors: Wang Shen-cheng , Chan Kin-sun , Han Ke-qing 
Published: November 2019

Purpose
Aiding employment is an important poverty reduction strategy in many countries’ social welfare systems, as this strategy can help empower the recipients with a better living standard, development and social inclusion. The purpose of this paper is to identify the most significant individual and systematic variables for the employment status of low-income groups in urban China.

Design/methodology/approach
The data of this study are drawn from “Social Policy Support System for Poverty-stricken Families in Urban and Rural China 2015” report. The Ministry of Civil Affairs of the People’s Republic of China appointed and funded the Institute of Social Science Survey (ISSS) at Peking University to deliver the related project and organize a research team to write the report. Multiple binary logistic regression analysis is adopted to identify both individual and systematic factors that affect the employment status among low-income groups in urban China.

Findings
According to the results of the binary logistic regression model, individual factors, including: gender; householder status; education; and self-rated health status, play a significant role in determining the employment status of low-income groups in urban China. Clearly, the impacts of individual factors are more influential to marginal families than to families entitled to receive Basic Living Allowance. In contrast, compared with marginal families, systematic factors are more influential to families entitled to receive Basic Living Allowance.

Originality/value
This study highlights the importance of precise poverty reduction strategy and the issue of “welfare dependence” among low-income groups in urban China. Policy recommendations derived from the findings are hence given, including: the promotion of family-friendly policies; the introduction of a smart healthcare system; the establishment of a Basic Living Allowance adjustment mechanism; and the provision of related social services.
Measuring internal service quality: the case of the Greek public higher education institutions
Authors: Skarpeta Kornilia , Koemtzi Maria , Aidonis Dimitrios 
Published: November 2019

Purpose
The purpose of this paper is to investigate the idea of internal service quality in public organizations. An attempt is made to determine the key elements that define the concept of internal service quality and to identify the factors that support the attainment of high levels of internal quality. Internal service quality refers to the quality of services offered between units and/or employees within an organization and achieving internal quality in public authorities can contribute to the sustainability of the public sector.

Design/methodology/approach
A survey was conducted among administrative staff of the publicly owned Greek Higher Education Institutions. The research instrument uses a three-level approach on internal service quality: individual, departmental and organizational. The model was tested using exploratory and confirmatory factor analysis.

Findings
Findings reveal a five-factor structure of internal service quality by adding the factors of interdepartmental quality and the human aspect of internal service provision. Analysis of the data suggests that internal service quality is dependent on the level of responsibility of the respondent’s job.

Research limitations/implications
There is evidence that the individual internal service quality factor needs to be enhanced with more items. In addition, in order to gain generalizable results, further research should be conducted in various types of public organizations.

Originality/value
This study examines a questionnaire that evaluates internal service quality and proposes a basic five-factor model for estimating this type of service quality. It also triggers the use of internal service quality theory within public sector organizations.
The effects of integrating behavioral health into primary care for low‐income children
Authors: Cole Megan B. , Qin Qiuyuan , Sheldrick Radley C. , Morley Debra S. , Bair‐Merritt Megan H. 
Published: November 2019

AbstractObjectiveTo evaluate the impact of TEAM UP—an initiative that fully integrates behavioral health services into pediatric primary care in three Boston‐area Community Health Centers (CHCs)—on health care utilization and costs.Data Sources2014‐2017 claims data on continuously enrolled children from a Massachusetts Medicaid managed care plan.Study DesignWe used a difference‐in‐difference approach with inverse probability of treatment weights to compare outcomes in children receiving primary care at TEAM UP CHCs versus comparison site CHCs, in the pre (2014‐2016q2)‐ versus post (2016q3‐2017)‐intervention periods. Utilization outcomes included emergency department visits, inpatient admissions, primary care visits, and outpatient/professional visits (all cause and those with mental health (MH) diagnoses). Cost outcomes included total cost of care (inpatient, outpatient, professional, pharmacy). We further assessed differential effects by baseline MH diagnosis.Principal FindingsAfter 1.5 years, TEAM UP was associated with a relative increase in the rate of primary care visits (IRR = 1.15, 95% CI 1.04‐1.27, or 115 additional visits/1000 patients/quarter), driven by children with a MH diagnosis at baseline. There was no significant change in avoidable health care utilization or cost.ConclusionsExpanding the TEAM UP behavioral health integration model to other sites has the potential to improve primary care engagement in low‐income children with MH needs.