bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dupilumab treatment ameliorates clinical and hematological symptoms, including blood eosinophilia, in patients with atopic dermatitis
Authors: Yamauchi Teruo , Sasaki Shun , Lee Eun Seon , Tamura Takayuki , Seki Marina , Miwa Tasuku , Kobayashi Kae , Saruta Yusuke , Kitami Yuki , Sueki Hirohiko , Watanabe Hideaki 
Published: September 2020

AbstractBackgroundAtopic dermatitis (AD) is an allergic disease that affects individuals of various ages. Recently, the IL‐4/13 inhibitor dupilumab has gained regulatory approval for clinical use in AD patients. Dupilumab has been reported to reduce several markers of AD, including the serum levels of thymus and activation‐regulated chemokine (TARC/CCL17), blood lactate dehydrogenase (LDH), and serum total immunoglobulin E (IgE).MethodsWe retrospectively reviewed data from 40 AD patients who were treated with dupilumab. Eczema Area and Severity Index (EASI), Investigator’s Global Assessment (IGA), body surface area (BSA) scores, TARC, LDH, total IgE, and eosinophil count in peripheral blood were assessed for a total of 32 weeks.ResultsThe EASI, IGA, and BSA scores improved significantly with treatment, indicating a reduction in AD severity. Serum TARC and LDH levels also significantly decreased with treatment. Serum IgE levels were unchanged at 2 weeks of treatment but decreased significantly between 4 and 32 weeks. The number of eosinophils in the peripheral blood decreased at 4, 16, and 32 weeks after treatment initiation.ConclusionsSeveral studies have reported that serum TARC, LDH, and total IgE levels are reduced by dupilumab treatment. Our real‐world data are the first to demonstrate a reduction in blood eosinophilia in patients who receive clinical treatment with dupilumab.
Nebulous Intentioning – Acute hospital nurses’ struggle to deliver core nursing care
Authors: Lane Aoife , Landers Margaret , Andrews Tom 
Published: September 2020

AbstractAimTo explore the influences on nursing practice in acute hospital care.DesignA Classic Grounded Theory study.MethodsData collection (2013–2015) was through interviews and non‐participant observations. Analysis was undertaken using constant comparative data analysis and theoretical sampling. Memo writing was used as an aid to understanding and conceptualizing data during analysis. Theoretical coding served to integrate emerging concepts.ResultsThis theory explains core nursing as a nebulous intention, an idea which acute care nurses retain throughout each shift, that they will nurse their patients fully when they have the opportunity. It reveals this as the resolution of their main problem which is the constant deferral of core nursing care. This study explains its two sub‐core categories, accommodating and integrity eroding.ConclusionThe theory highlights nurses’ attitudes towards their role, demonstrated by deferring it to accommodate the work of others, but offers a new perspective on the significant contribution nurses make to the safe and cohesive transition of patients through the acute healthcare system.ImpactThe theory adds a new understanding of the unique contribution nurses make to patient health and safety in acute care environments. It also provides insight into nurses’ attitudes towards their own professional work. It explains the consequences of attitudes which undermine core nursing when it competes for priority with accommodating. Accommodating indicates a greater workload for nurses than has been previously understood in explaining the activities, additional to core nursing care, which nurses undertake to contribute safety and cohesion to the patient's acute care journey. These new insights suggest a role for managers in recognizing accommodating in decisions about staffing and resources and for educators in improving the profession's regard for its theoretical underpinnings and for its self‐image.
Loricaria cuffyi (Siluriformes: Loricariidae), a new species of loricariin catfish from the Guiana Shield
Authors: Londoño‐Burbano Alejandro , Urbano‐Bonilla Alexander , Thomas Matthew R. 
Published: September 2020

AbstractLoricaria cuffyi n. sp. is described based on 36 specimens from the Essequibo and upper Negro River drainages in western Guyana and the upper Orinoco River drainage in Venezuela. The new species can be distinguished from sympatric and geographically proximate congeners by a postorbital notch that is inconspicuous, shallow and rounded, odontode ridges on the dorsum of head and predorsal weakly developed, abdominal plates tightly joined and completely covering the median abdominal space and pectoral girdle, higher anterior lateral plate counts, and coloration characteristics. The distribution of the new species adds to an interesting and well‐documented biogeographical pattern exhibited by other Guiana Shield loricariids influenced by the proto‐Berbice during the Cenozoic and recent configuration of drainages in the Guiana Shield. We present an update on the taxonomy of Loricaria, and discuss the biogeography and conservation status of the new species.
Soybean oil deacidification by liquid–liquid extraction using hydrous ethanol
Authors: de Sá Letícia Andrade , Capellini Maria Carolina , Rodrigues Christianne E. C. , Meirelles Antonio J. A. 
Published: September 2020

AbstractSoybean oil (SO) was deacidified by liquid–liquid extraction (LLE) in a perforated rotating disc column using ethanol as solvent. The extraction assays were performed using two approaches: in the first, response surface methodology (RSM) was used to evaluate the effect of perforated discs' rotation speed and solvent hydration on the transfer of free fatty acids (TFFA), loss of neutral oil (LNO), and overall volumetric mass transfer coefficient (KR·a) in assays using refined SO. In second, the best conditions from RSM were used in the degummed SO deacidification; in this case, the influence of phospholipids on the LNO was observed. The maximization of the values of TFFA and LNO occurs for low water contents in the solvent, regardless of discs' rotation speed. Regarding KR·a, both independent variables influence this response. An increase in hydration of the solvent decreases the KR·a by decreasing the free fatty acid (FFA) diffusivity. The total deacidification of degummed SO by LLE is feasible using ethanol with 10 mass% water and a rotation speed of 150 rpm. These process conditions provided reduction on phosphorus, peroxide value, and FFA, along with a low loss of neutral oil, which was significantly lower than the values reported for the traditional process, alkali refining.Practical applicationsThis study is useful to vegetable oil processors and researchers because it is addressed the issue of using a softer deacidification process than traditional methods, which permits to remove free fatty acids, avoiding excessive losses of neutral oil and minimizing the effluent generation when compared to chemical refining. Besides, this process can be accomplished at a temperature below the normal boiling point of the solvent and atmospheric pressure, softer conditions of pressure and temperature than physical method that uses desorption with water vapor, reducing the energy consumption of oil refining. This alternative deacidification process by liquid–liquid extraction uses ethanol, a generally recognized as safe (GRAS) solvent, which allows minimizing the losses of nutraceutical compounds present in the oil. In fact, this study provides data that can be used to design a renewable solvent‐based soybean oil deacidification process.
Relationship between zinc content and carbonic anhydrase activity in blood of anemic pregnant women in Turkey
Authors: Göktuğ Kadıoğlu Berrin , Nalçakan Aysel , Dilek Esra 
Published: September 2020

AbstractAimsCarbonic anhydrase (CA) in pregnancy plays an important part in gaseous exchange across the placenta. The aim of our study was to determine the relationship between zinc content and the CA activity in blood of anemic and normal pregnant women in their third trimester, in Turkey.MethodsThe patients with hemoglobin values below 11 g/dL were accepted as anemic. CA enzyme activity and zinc levels in erythrocyte of anemic and non‐anemic pregnant women were carried out in 27 non‐anemic pregnant women and 31 anemic pregnant women. Mean corpuscular volume (MCV) levels of the participants were also tested.ResultsZinc levels were lower in the anemic group compared to the non‐anemic group (P = 0.049). Total CA enzyme activity was also lower in the anemic group (P = 0.044). MCV levels were found to be lower in the anemic group (P = 0.007). The decrease in these values was statistically significant (P < 0.05).ConclusionThis is the first study to evaluate the zinc content in red blood cells of anemic pregnant women in the third trimester and its relationship with carbonic anhydrase activity. CA isoenzymes to work healthily, providing iron and zinc supports is important for fetal development.
Patient‐reported outcome measures of edentulous patients restored with single‐implant mandibular overdentures: A systematic review
Authors: Fu Liangliang , Liu Gufeng , Wu Xiaoyi , Zhu Zhenzhen , Sun Huifang , Xia Haibin 
Published: September 2020

AbstractAimTo review the literatures concerning the effect of the single‐implant mandibular overdenture (SIMO) on patient‐reported outcome measures (PROMs) and masticatory function in the fully edentulous patients.Materials and MethodsElectronic databases (PubMed, Cochrane Library, EMBASE and Web of Science) were searched, complemented with manual resources. Prospective studies published in English up to February 2020 reporting the effect of SIMO on PROMs and masticatory function in the edentulous patients were included. This review focused on oral health‐related quality of life (OHRQoL), satisfaction and masticatory function outcomes.ResultsOf 1157 initially screened articles, 9 randomised controlled trials (RCTs) and 8 prospective studies involving 551 subjects fulfilled the inclusion criteria. Two RCTs were graded as high risk of bias or some concern, while others were low risk. All prospective studies had adequate representativeness and assessment, but only one study had a controlled cohort. In general, the edentulous patients restored with SIMOs had improved OHRQoL and general satisfaction compared to those with conventional complete dentures (CCDs), but the outcome of masticatory function was controversial. Compared with two‐implant mandibular overdenture (TIMO), SIMO showed no significant differences regarding general satisfaction and satisfaction with speech, comfort, chewing ability, aesthetics and social life. Conflicting results were observed in OHRQoL and satisfaction with retention and stability. Better masticatory performance was observed in TIMO group than SIMO group.ConclusionWithin the limitation of this review, SIMO is featured with better OHRQoL and satisfaction than CCD. SIMO and TIMO rendered similar patient satisfaction, but TIMO had better masticatory performance.
The Selves of Lindsey
Authors: Cahoone Lawrence 
Published: September 2020

AbstractKathleen Wallace’s The Network Self: Relation, Process, and Personal Identity (2019) presents an understanding of personal identity and selfhood. Its central conundrum is how a person or self can be a something that, while being related to and even constituted by many things, including endless experiences and events and social roles, hence subject to continuous change, can nevertheless sustain an identity capable of responsible agency and all the other moral and narrative predicates so crucial to us. In response Wallace creates a Cumulative Network Model of the self, rooted in the relational and social analysis of human individuality characteristic of the American philosophical tradition, that, while processural and complex in the extreme, is nevertheless capable of autonomy and responsibility. Her account provides a novel paradigm for the analysis of human self, but with its very complexity raises questions as to the relation between the referents of “person,” “self,” and “I.”
Kathleen Wallace and the Network Self
Authors: Pratt Scott L. 
Published: September 2020

AbstractKathleen Wallace makes an important contribution to the theoretical frameworks available to understanding the nature of selves. Drawing on the theory of natural complexes proposed by Justus Buchler, Wallace proposes the “cumulative network model” (CNM) of selves. This article provides an overview of CNM, suggests its relation to recent New Materialist theories of agency, ideas of power, and the American philosophical tradition, and proposes that it can serve as a new resource in discussions of pressing problems faced in today’s world.
The cost‐effectiveness of isavuconazole compared to voriconazole, the standard of care in the treatment of patients with invasive mould diseases, prior to differential pathogen diagnosis in Spain
Authors: Azanza José Ramón , Grau Santiago , Vázquez Lourdes , Rebollo Pablo , Peral Carmen , López‐Ibáñez de Aldecoa Alejandra , López‐Gómez Vanessa 
Published: September 2020

AbstractBackgroundInvasive mould diseases are associated with high morbidity, mortality and economic impact. Its treatment is often started prior to differential pathogen diagnosis. Isavuconazole is approved for treatment of invasive aspergillosis (IA) and invasive mucormycosis (IM) when amphotericin‐B is not indicated.ObjectivesTo estimate the cost‐effectiveness of isavuconazole vs voriconazole for the treatment of adult patients with possible IA prior to differential pathogen diagnosis, in Spain.MethodsA decision tree analysis was performed using the Spanish Healthcare System perspective. Among all patients with possible IA, it was considered that 7.81% actually had IM. Costs for laboratory analysis, management of adverse events, hospitalisation and drugs per patient, deaths and long‐term effects in life years (LYs) and quality‐adjusted LYs (QALYs) were considered. Efficacy data were obtained from clinical trials and utilities from the literature. Deterministic and probabilistic sensitivity analyses (PSA) were conducted.ResultsIn patients with possible IA and when compared to voricanozole, isavuconazole showed an incremental cost of 4758.53€, besides an incremental effectiveness of +0.49 LYs and +0.41 QALYs per patient. The Incremental Cost Effectiveness Ratio was 9622.52€ per LY gained and 11,734.79€ per QALY gained. The higher cost of isavuconazole was due to drug acquisition. Main parameters influencing results were mortality, treatment duration and hospitalisation days. The PSA results showed that isavuconazole has a probability of being cost‐effective of 67.34%, being dominant in 24.00% of cases.ConclusionsIsavuconazole is a cost‐effective treatment compared to voriconazole for patients with possible IA for a willingness to pay threshold of 25,000€ per additional QALY.
Tooth ultrastructure of a novel COL1A2 mutation expanding its genotypic and phenotypic spectra
Authors: Intarak Narin , Budsamongkol Thunyaporn , Theerapanon Thanakorn , Chanamuangkon Theerapat , Srijunbarl Anucharte , Boonprakong Lawan , Porntaveetus Thantrira , Shotelersuk Vorasuk 
Published: September 2020

AbstractObjectivesTo investigate tooth ultrastructure and mutation of two patients in a family affected with osteogenesis imperfecta (OI) type IV and dentinogenesis imperfecta (DGI).MethodsMutations were detected by whole exome and Sanger sequencing. The permanent second molar obtained from the proband (DGI1) and the primary first molar from his affected son (DGI2) were studied for their color, roughness, mineral density, hardness, elastic modulus, mineral content, and ultrastructure, compared to the controls.ResultsTwo novel missense COL1A2 variants, c.752C > T (p.Ser251Phe) and c.758G > T (p.Gly253Val), were identified in both patients. The c.758G > T was predicted to be the causative mutation. Pulp cavities of DGI1 (permanent teeth) were obliterated while those of DGI2 (primary teeth) were wide. The patients’ teeth had darker and redder colors; reduced dentin hardness; decreased, disorganized, and scattered dentinal tubules and collagen fibers; and irregular dentinoenamel junction (DEJ), compared to controls. Lacunae‐like structures were present in DGI2.ConclusionsWe reported the novel causative mutation, c.758G > T (p.Gly253Val), in COL1A2 for OI type IV and DGI. The DGI dentin demonstrated inferior mechanical property and ultrastructure, suggesting severe disturbances of dentin formation. These could contribute to fragility and prone to infection of DGI teeth. This study expands phenotypic and genotypic spectra of COL1A2 mutations.
Isolation, not locality
Authors: Demarest Heather , Hicks Michael Townsen 
Published: September 2020

AbstractThere is a long tradition of preferring local theories to ones that posit lawful or causal influence at a spacetime distance. In this paper, we argue against this preference. We argue that nonlocality is scientifically unobjectionable and that nonlocal theories can be known. Scientists can gather evidence for them and confirm them in much the same way that they do for local theories. We think these observations point to a deeper constraint on scientific theorizing and experimentation: the (quasi‐) isolation of causal or lawful influence. We argue that this requirement ought to replace the locality desideratum in science. We then explore the possibility that the order of explanation has been reversed: perhaps it is isolatable influence that determines what counts as local in the first place.
Mental health symptoms, spiritual well‐being and meaning in life among older adults living in nursing homes and community dwellings
Authors: Aydın Adeviye , Işık Abdullah , Kahraman Nilgün 
Published: September 2020

BackgroundAgeing is a process involving physical, social, psychological, spiritual and cultural changes. The elderly's personal characteristics may change, and the place where they live can lead to differences in their individual life expectations. Nursing home or community dwelling, where the elderly live can affect their psychological and spiritual well‐being and their search for meaning in life. This study aimed to determine mental health symptoms, spiritual well‐being and meaning in life among older adults living in nursing homes and community dwellings.MethodsThis cross‐sectional study was conducted in three provinces of Turkey with the highest population of elderly people aged 60 and above. A total of 144 elderly people (71 living in nursing homes and 73 in community dwellings) participated in the study. The Descriptive Information Form, Brief Symptom Inventory (BSI), Spiritual Well‐Being Scale and Meaning in Life Questionnaire were used for data collection. For the statistical analysis, the Kruskal–Wallis test, Mann–Whitney U‐test and Spearman correlation analysis were applied.ResultsAbout 42.3% of the elderly living in nursing homes were aged 80 and above, while 61.6% of those living in community dwellings were in the age range of 60–69 years. The hostility score in the community‐dwelling elders was statistically higher than that of elders living in nursing homes. However, the harmony with nature score was lower in the community‐dwelling elders. Negative relationships were found between total spiritual well‐being and depression, anxiety, negative self and somatisation. Meanwhile, existing meaning in life found positive relationships among transcendence and harmony with nature.ConclusionsThe awareness of healthcare workers is very important in helping the elderly make sense of the changes they experience. Moreover these healthcare workers should undergo systematic training to help the elderly prepare for old age by making sense of preserving mental integrity and seeking meaning in their lives.
Intramammary antibiotics with complementary acupuncture decreases milk serum N‐acetyl‐beta‐D‐glucosaminidase concentrations in dairy cattle with subclinical mastitis
Authors: Ryan Elise Lauren , Klopfenstein Joseph J. , Kutzler Michelle Anne 
Published: September 2020

AbstractThe objective of this research is to determine whether intramammary antibiotics with complementary acupuncture can reduce bovine mammary inflammation due to subclinical mastitis. Lactating cows were selected based on milk with a somatic cell count (SCC) greater than 500,000 cells/ml. Pre‐ and post‐treatment milk samples were collected to determine SCC, aerobic bacterial content, milk ion conductivity, total protein, lactate dehydrogenase (LDH) and N‐acetyl‐beta‐D‐glucosaminidase (NAGase) concentrations. Milk serum was prepared from milk samples by double centrifugation. Concentrations of LDH and NAGase were determined using commercial enzyme‐linked immunosorbent assays. Cows being treated with intramammary antibiotics were separated by random assignment to the acupuncture group (n = 10) and a no‐acupuncture (control) group (n = 9). Both the acupuncture and control group were restrained for 30 min in a head catch 12 hr apart for a total of four times. For front quarters affected by subclinical mastitis, the acupuncture points used were spleen (SP) 12, SP 17, SP 18, SP 21, stomach (ST) 18 and conception vessel (CV) 12. For rear quarters affected by subclinical mastitis, the acupuncture points used were bladder (BL) 30, BL 30‐1, BL 49, kidney (KI) 10, conception vessel (CV) 2 and CV 3. All parameters were compared using a Student t test. Significance was defined as p < .05. Compared to control cows, complementary acupuncture treatment reduced NAGase enzymatic activity in quarters of cows with subclinical mastitis. The reduction in NAGase suggests that complementary acupuncture treatment may be associated with healing of the damaged mammary epithelial cells, which are the primary source of NAGase activity in milk serum.
How accurate is the assessment of certified nursing assistants on resident's oral self‐care function in three North Carolina assisted‐living facilities?
Authors: Chen Xi , D'Souza Violet , Comnick Carissa L , Xie Xianjin 
Published: September 2020

AbstractAimsTo examine the association between the assessments of certified nursing assistants (CNAs) on resident's oral self‐care function and resident's oral hygiene outcomes in three North Carolina assisted‐living (AL) facilities.Methods and resultsSixty‐five dentate AL residents were included in this secondary analysis. CNAs were asked to rate the AL residents’ overall oral self‐care function using a 6‐point Likert scale. Their assessments were then compared with the objective, performance‐based Dental Activities Test and the oral hygiene and gingival health measures. The analysis showed that nearly 90% of the participants presented with at least one untreated decayed or broken tooth. On average, nearly two‐thirds of the surfaces were covered by soft deposits (Debris Index = 1.83, SD = 0.60). Generalized mild to moderate inflammation (Gingival Index = 1.51, SD = 0.53) commonly presented on residents’ gingiva. CNAs were able to accurately identify the residents with substantial impairment in oral self‐care function, yet they tended to overestimate the oral self‐care function of residents with mild to moderate impairment. CNAs assessments were also not significantly correlated with residents’ oral hygiene measures.ConclusionCNAs failed to identify and provide assistance to AL residents with impaired oral self‐care function, contributing to poor oral oral hygiene in these vulnerable individuals.