bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life and Prolonged Symptoms in Korean Breast Cancer Survivors
Authors: Jang Min Kyeong , Kim Sue , Park Chang Gi , Collins Eileen G. , Quinn Lauretta T. , Ferrans Carol Estwing 
Published: September 2020

Background
A culture of serious overwork in South Korea, more than other developed countries, may impact symptoms and quality of life (QOL) experienced by Korean breast cancer survivors (BCS).

Objectives
The aim of this study was to examine health-related QOL and influencing factors in BCS in Seoul, Korea, who have recovered from treatment for at least 1 year and returned to normal life and work.

Methods
In a cross-sectional study, 199 BCS completed a self-administered questionnaire in Seoul, Korea.

Results
Mean QOL scores were lower than expected, with 49% of the variance explained by depressive symptoms, physical fatigability, cognitive impairment, and social support. Psychological distress was high (67.8%), along with anxiety (47.2%) and depressive symptoms (36.7%). Participants reported a high prevalence of physical fatigability (71.1%), sleeping an average of only 6 hours per night, with 58.9% reporting poor quality sleep.

Conclusions
Quality of life was lower in Korean BCS than comparable studies in the United States, although participants received care at a premiere medical center. Depressive symptoms and anxiety were common and did not taper off over the 5 years after diagnosis, unlike BCS elsewhere. Korean survivors experienced significant physical fatigability, much higher than reported in a US study of mixed male and female cancer survivors. Overwork was not a significant predictor of QOL, although 30% of employed women reported working 45 to 90 hours weekly.

Implications for Practice
Findings demonstrate the importance of continued efforts to mitigate these symptoms in clinical survivorship care, as well as future research, to provide avenues for improving QOL for BCS, particularly in Korea.
99mTc-MIP-1404 SPECT/CT for Assessment of Whole-Body Tumor Burden and Treatment Response in Patients With Biochemical Recurrence of Prostate Cancer
Authors: Schmidkonz Christian , Götz Theresa Ida , Atzinger Armin , Ritt Philipp , Prante Olaf , Kuwert Torsten , Bäuerle Tobias , Goebell Peter , Cordes Michael 
Published: September 2020

Objective
This study aims to investigate the value of 99mTc-MIP-1404 SPECT/CT for assessment of whole-body tumor burden and treatment response in patients with biochemical recurrence of prostate cancer who undergo androgen deprivation therapy (ADT) or external beam radiation therapy (EBRT).

Methods
A total of 125 patients with biochemical recurrence of prostate cancer underwent 99mTc-MIP-1404 SPECT/CT. All 364 prostate-specific membrane antigen (PSMA)–positive lesions in the field of view were assessed quantitatively to calculate PSMA-derived metabolic tumor parameters, including whole-body PSMA tumor volume and whole-body total lesion PSMA. These metrics were correlated with serum prostate-specific antigen (PSA) levels and Gleason scores. In a subset of 50 patients who underwent 99mTc-MIP-1404 SPECT/CT before the initiation of ADT or EBRT, TL-PSMA and SUVmax were compared with radiographic response assessment by CT based on RECIST 1.1 and to biochemical response (BR) determined by changes in serum PSA levels.

Results
Serum PSA levels correlated with SUVmax, whole-body PSMA tumor volume, and whole-body total lesion PSMA in patients with 1 and in those with more than 1 PSMA-positive lesion (P < 0.05). The correlations were significant for both well-differentiated (Gleason score ≤7) and poorly differentiated tumors (Gleason score ≥8) (P < 0.05). The agreement between TL-PSMA derived from SPECT and BR in patients who underwent 99mTc-MIP-1404 SPECT/CT before and after initiation of ADT was 80% (95% confidence interval [CI], 0.43–0.91; Cohen κ = 0.68; P < 0.05); in these patients, the agreement between TL-PSMA and CT was 60% (95% CI, 0.20–0.72; Cohen κ = 0.46; P < 0.05) and the agreement between BR and CT was 52% (0.07–0.61; Cohen κ = 0.34; P < 0.05). Comparable results were found for patients who underwent SPECT/CT before and after initiation of EBRT, with the strongest agreement between TL-PSMA and BR (80%; 95% CI, 0.38–0.93; Cohen κ = 0.66; P < 0.05) compared with the agreement between TL-PSMA and CT (60%; 95% CI, 0.13–0.69; Cohen κ = 0.69; P < 0.05) and between BR and CT (48%; 95% CI, 0–0.54; Cohen κ = 0.26; P = 0.11). Discordant findings between SPECT and CT were most likely due to limitations in the assessment of small lymph node metastases and bone involvement, which were detectable on SPECT but not on CT.

Conclusions
The results of our study show that 99mTc-MIP-1404 SPECT/CT is a promising method for the evaluation of treatment response in patients with biochemical recurrence of prostate cancer who undergo either ADT or EBRT. TL-PSMA for assessment of treatment response has the strongest correlation with serum PSA levels, superior to SUVmax-based evaluation and response assessment based on CT data and RECIST 1.1.
Unusual Case of an Exophytic Leiomyoma of Rectum Mimicking Malignancy on 18F-FDG PET/CT
Authors: Li Chongjiao , Tian Yueli , Shen Ying , Wen Bing , He Yong 
Published: September 2020

Abstract
Rectal leiomyoma is an exceedingly rare benign lesion. We here report a case with extraluminal leiomyoma of the middle and lower parts of the rectum showing aberrant hypermetabolism on 18F-FDG PET/CT in a 54-year-old man.
Isolated Pancreatic Metastasis From Choroidal Melanoma After 10 Years of Enucleation Mimicking Neuroendocine Tumor on 68Ga-DOTANOC PET/CT
Authors: Shamim Shamim Ahmed , Tripathy Sarthak , Rastogi Sameer , Barwad Adarsh , Prakash Sneha 
Published: September 2020

Abstract
Isolated pancreatic metastasis from choroidal melanoma is a rare phenomenon. We describe a case of a 38-year-old woman who underwent enucleation surgery for right choroidal melanoma and subsequently developed lesions in the pancreas 10 years after enucleation, which were depicted on 68Ga-DOTANOC PET/CT and confirmed to be metastasis from choroidal melanoma on surgical histopathology.
Pseudoprogression on 68Ga–Prostate-Specific Membrane Antigen-11 PET/CT in a Treated Glioblastoma
Authors: Gupta Manoj , Choudhury Partha Sarathi , Gairola Munish , Premsagar Ishwar Chandra , Rao Sriram Avinash 
Published: September 2020

Abstract
After standard treatment of glioblastoma, pseudoprogression versus true progression is a clinical challenge. Indeed, to differentiate these 2 on contrast MRI (cMRI) is problematic. In recent time, 68Ga–prostate-specific membrane antigen-11 (68Ga-PSMA) PET/CT has been suggested to have high accuracy in glioblastoma recurrence. We present a case of a 40-year-old man with right frontotemporal glioblastoma underwent surgery and radiotherapy. One month posttreatment cMRI showed a new enhancing lesion in the right hippocampal region, which was also positive on 68Ga-PSMA-11 PET/CT. On follow-up with conservative management, both cMRI and 68Ga-PSMA-11 PET/CT showed regression in new lesion, hence suggest pseudoprogression.
10-Year Clinical Experience With 18F-Choline PET/CT
Authors: Zattoni Fabio , Ravelli Ilaria , Rensi Marco , Capobianco Decio , Borsatti Eugenio , Baresic Tania , Chiaravalloti Agostino , Schillaci Orazio , Alongi Pierpaolo , Bartolotta Tommaso Vincenzo , Rambaldi Ilaria , Bartolomei Mirco , Farsad Mohsen , Tredici Manuel , Donner Davide , Chierichetti Franca , Trifirò Giuseppe , Brugola Elisabetta , Burei Marta , Dal Moro Fabrizio , Cecchin Diego , Evangelista Laura 
Published: September 2020

Purpose
The primary aim of this multicenter retrospective analysis is to examine the role of 18F-choline PET/CT as a diagnostic tool for staging and restaging prostate cancer (PCa) in a large population in the light of 10 years of clinical experience. A secondary aim of the study is to produce data on the predictors of a positive 18F-choline PET/CT result in the setting of PCa primaries and biochemical recurrences.

Materials and Methods
This multicenter retrospective cohort study is based on data collected by 9 Italian nuclear medicine departments. Between October 2008 and September 2019, 3343 men underwent 18F-choline PET/CT scans before receiving definitive treatments for a primary PCa or biochemical recurrence. Inclusion criteria were (1) histologically proven PCa (on surgical specimens or prostate biopsies from patients not treated surgically) and (2) availability of clinical and pathological data, including serum prostate specific antigen (PSA) level at the time of PET/CT scanning.

Results

18F-choline PET/CT was performed in 545 cases (16.4%) for cancer staging and in 2798 (83.6%) for restaging purposes, and the result was positive in 540 (99.1%) for the former and 1993 (71.2%) for the latter. A positive PET/CT result was always associated with a high Gleason score (>7) and high PSA levels (P < 0.01). The percentage of patients with a PSA threshold less than 1.0 ng/mL for performing PET/CT was higher in the years 2014 to 2019 (n = 341, 25% of cases) than during the previous period (n = 148, 16%; in 2008–2013). When used for staging purposes, receiver operating characteristic analysis showed that PSA levels of 9.2, 16.4, and 16.6 ng/mL were the optimal cutoffs for distinguishing between positive and negative PET/CT findings for local disease, lymph node involvement, and metastasis, respectively. In the restaging setting, a PSA level of 1.27 ng/mL was the optimal cutoff for distinguishing between a positive and negative PET/CT scan.

Conclusions

18F-choline PET/CT can help identify early recurrences, even in the case of low PSA levels (<1 ng/mL). Our data suggest that important improvements have been made in the interpretation of 18F-choline images and in patient selection in the last 5 years.
Widespread Skin Infiltration of Leukemia Cutis on 18F-FDG PET/CT
Authors: Zheng Jieling , Xue Qianqian , Lin Kaixian , Miao Weibing 
Published: September 2020

Abstract
A 67-year-old man experienced multiple cutaneous nodules for 3 weeks. His initial skin biopsy only showed local inflammation. However, after a 2-week anti-inflammation therapy, the skin manifestations were not improved while the leukocyte count gradually increased. FDG PET/CT revealed widespread cutaneous and subcutaneous hypermetabolic lesions in many parts of the body, and heterogeneously increased uptakes in the bone marrow. Bone marrow biopsy and second skin biopsy were performed. Pathological examination from both specimen demonstrated acute monocytic leukemia.
18F-Fluciclovine PET/MRI in a Patient With Squamous Cell Carcinoma of the Uterine Cervix Correlated With 18F-FDG PET/CT
Authors: Nguyen Nghi C. , Moon Chan Hong , Beriwal Sushil 
Published: September 2020

Abstract
A 32-year-old woman with a FIGO (International Federation of Gynecology and Obstetrics) stage IIA invasive squamous cell carcinoma of the uterine cervix underwent a clinical FDG PET/CT scan, which revealed intense uptake in the primary. On research 18F-fluciclovine PET/MRI, the primary showed elevated fluciclovine uptake at 5 and 40 minutes after radiotracer injection, with no evidence of regional or distant metastasis. Fluciclovine PET may have diagnostic value for cervical cancer imaging with a potential advantage over FDG of minimal urinary activity from renal excretion; however, in this patient, the metabolic activity was inferior to that of FDG PET.
FDG PET/CT Suggesting Pulmonary Artery Involvement of Takayasu Arteritis
Authors: Liu Yong , Tong Guansheng , Wen Zhe 
Published: September 2020

Abstract
Pulmonary artery involvement can occur in about half of the patients suffering Takayasu arteritis. Increased FDG activity in the aorta and its main branches in patients with Takayasu arteritis on PET/CT had been well-reported. However, the FDG PET/CT appearance of pulmonary artery involvement in Takayasu arteritis is less known. We present FDG PET/CT findings in a 37-year-old patient with known Takayasu arteritis. The images showed rim-like FDG activity in opacities in the left lung, which was later proven due to narrowed left main pulmonary artery.
18F-FDG PET/CT in Xanthoma Disseminatum
Authors: Arslan Esra , Aksoy Tamer , Leblebici Cem , Koku-Aksu Ayşe Esra , Çermik Tevfik Fikret 
Published: September 2020

Abstract
A 64-year-old woman who had yellowish orange–colored, sharp-edged, and flat skin plaques and back pain for about a year was referred for 18F-FDG PET/CT imaging and her bone marrow biopsy revealed 10% to 20% atypical plasma cells suggestive of monoclonal gammopathy. PET/CT showed linear 18F-FDG uptake on the surface of the skin on the neck, axillary, chest, inframammary, and inguinal regions. Punch biopsy revealed numerous histiocyte infiltrates with large vacuoles, xanthomized cytoplasm in the dermis, and midsection, and there are several Touton-type giant cells supporting the preliminary diagnosis of xanthoma disseminatum.
99mTc-MDP Bone Scan Findings in Fibrodysplasia Ossificans Progressiva
Authors: Gupta Nitin , Verma Ritu , Belho Ethel Shangne , Dey Sudip 
Published: September 2020

Abstract
Fibrodysplasia ossificans progressiva is a rare debilitating, connective tissue disease characterized by progressive extraosseous ossification with abnormal great toes. Clinical (hallux valgus), radiological, and classical bone scan findings help to reach diagnosis and prevent patient from unnecessary surgical interventions for fibrodysplasia ossificans progressiva lesions and radiotherapy cycles. Here we present a case where a child presented with multiple swellings over the body and hallux valgus, and further bone scan findings helped to reach the diagnosis. The progressive nature of disease is difficult to halt, but early diagnosis can help in the delay of the disease process, by preventing trauma and giving disease-modifying agents.
Incidental COVID-19 Pneumonia on 18F-Fluorocholine PET/CT
Authors: García Vicente Ana María , Soriano Castrejón Ángel 
Published: September 2020

Abstract
We present the case of a patient who underwent 18F-fluorocholine PET/CT for biochemical recurrence of prostate cancer in which bilateral pneumonia was diagnosed. In the current state of COVID-19 pandemic, a high prevalence of incidental pneumonia may be expected, even with previous clinical triage, explained by a nondefined number of patients who were asymptomatic or minimally symptomatic for infectious process. Therefore, nuclear medicine physicians should be prepared to recognize and diagnose incidental COVID-19 pneumonia manifestation on 18F-fluorocholine PET/CT, due to the crucial epidemiological implications.
Head-to-Head Comparison of the Two MAO-B Radioligands, 18F-THK5351 and 11C-L-Deprenyl, to Visualize Astrogliosis in Patients With Neurological Disorders
Authors: Ishibashi Kenji , Kameyama Masashi , Miura Yoshiharu , Toyohara Jun , Ishii Kenji 
Published: September 2020

Abstract
Three patients with neurological disorders (cerebral infarction, progressive multifocal leukoencephalopathy, and multiple sclerosis) underwent 18F-THK5351 and 11C-L-deprenyl PET on the same day to visualize lesions undergoing astrogliosis by measuring MAO-B activity. BP
ND map and SUV image with 18F-THK5351 as well as K
i map, K
i/K
1 map and SUV image with 11C-L-deprenyl were created. 18F-THK5351 BP
ND maps and SUV images clearly identified the lesions undergoing astrogliosis. 11C-L-deprenyl K
i/K
1 maps were close to 18F-THK5351 images, but very noisy. K
i maps and SUV images were likely affected by the effect of blood flow. Hence, 18F-THK5351 is superior to 11C-L-deprenyl for visualizing lesions undergoing astrogliosis.
18F-FDG PET/CT in Labrune Syndrome
Authors: Cuzzocrea Marco , Florimonte Luigia , Scola Elisa , Benti Riccardo , Castellani Massimo 
Published: September 2020

Abstract
A 69-year-old woman presented with cognitive impairment related to attentive, executive, and mnemonic functions; progressive worsening of walking, speaking, writing, and reading ability; and double sphincter incontinence. Leukoencephalopathy, cystic lesions, and calcifications, suspected for Labrune syndrome, were observed at MRI and CT brain images. Generalized wave abnormalities were also visible at electroencephalogram. Functional brain imaging performed with 18F-FDG PET/CT demonstrated a decreased glucose metabolism in impaired brain regions, in accordance with MRI findings. Genetic testing confirmed a mutation of SNORD118.
Successful and Safe Treatment With 177Lu-DOTATATE (Lutathera) of Progressive Metastatic Pancreatic Neuroendocrine Tumor Under Hemodialysis
Authors: Dierickx Lawrence O. , Séverine Brillouet , Fatima Mokrane , Amel Bensafi , Rosine Guimbaud 
Published: September 2020

Abstract

177Lu-DOTATATE is an effective treatment for inoperable metastatic well-differentiated pancreatic neuroendocrine tumors. There are no guidelines for patients with terminal renal failure. We present the case of a 74-year-old woman who received different lines of treatment: analogs of somatostatin, chemotherapy, a first series of peptide receptor radionuclide therapy (PRRT), and finally chemoembolization. Because of persistent hepatic progression, a safe and successful administration of 4 cycles of a second series of PRRT under hemodialysis was administered. Patient was in scintigraphic complete remission at 12 months with normal hematological parameters at 12 and 30 months after PRRT.
Sentinel Node Imaging and Radioguided Surgery in the Era of SPECT/CT and PET/CT
Authors: Valdés Olmos Renato Alfredo , Rietbergen Daphne D. D. , Rubello Domenico , Pereira Arias-Bouda Lenka M. , Collarino Angela , Colletti Patrick M. , Vidal-Sicart Sergi , van Leeuwen Fijs W. B. 
Published: September 2020

Abstract
We review recent technological advances and new clinical indications for sentinel node (SN) and radioguided surgery in order to delineate future tendencies of interventional nuclear medicine in this field. A literature research was performed in PubMed to select relevant articles to be used as key references for analysis of the current approaches and tendencies in SN and radioguided surgery, as well as the evolving contribution of nuclear medicine intervention techniques to the various clinical applications. For classic indications such as melanoma and breast cancer, the incorporation of the SN approach based on the combined use of existing and new preoperative and intraoperative technologies in high-risk patient categories is becoming an emerging area of clinical indication. For SN biopsy staging in other malignancies with more complex lymphatic drainage, the incorporation of sophisticated tools is most helpful. The consecutive use of PET/CT and the SN procedure is increasing as a potential combined approach for the management of specific areas such as the axilla and the pelvis in patients at high risk of regional dissemination. Also, for the management of locoregional metastasis and oligometastatic disease, interventional nuclear medicine techniques are becoming valuable alternatives. The extended experience with SN biopsy is leading to technological advances facilitating the incorporation of this procedure to stage other malignancies with complex lymphatic drainage. New nuclear medicine–based approaches, incorporating SPECT/CT and PET/CT to guide resection of SNs and occult metastases, have recently been gaining ground.
Potential False-Positive Meckel’s Scan Caused by Umbilical Ornamentation
Authors: Pillenahalli Maheshwarappa Ravishankar , Menda Yusuf 
Published: September 2020

Abstract
An 18-year-old woman presented to the emergency department for bloody stools. A CT scan of the abdomen ruled out intussusception. Meckel’s scan was ordered to rule for Meckel’s diverticulum before upper endoscopy and colonoscopy. After proper pretreatment with H2 blocker, 99mTc-pertechnetate Meckel’s scan was performed. Dynamic planar imaging revealed a focus of gradual increase in uptake in midabdomen suggestive of Meckel’s diverticulum. A SPECT/CT was done to localize the focus of uptake. Surprisingly, the focus of uptake localized to the periumbilical region on SPECT/CT images. The cause of uptake could be due to local inflammation from umbilical ornamentation.
Multiple Cutaneous Leiomyomas Showing Increased FDG Uptake
Authors: Ji Xia , Bi Hongda , Dong Aisheng 
Published: September 2020

Abstract
Cutaneous leiomyomas are rare, sporadic, or inherited benign tumors arising from smooth muscle cells of the skin associated with various disorders. We present a case of multiple cutaneous leiomyomas showing increased FDG uptake with SUVmax of 19.9. This case indicates cutaneous leiomyoma should be considered as a rare differential diagnosis in patients with hypermetabolic cutaneous lesions. Careful correlation with clinical history is needed to avoid misdiagnosis.
Talocalcaneal Coalition With Os Sustentaculum
Authors: Usmani Sharjeel , Muzaffar Samreen , Al Kandari Fareeda , Ahmed Najeeb , Rehman Uzma 
Published: September 2020

Abstract
Os sustentaculi is a rare accessory bone of the foot located along the posterior end of sustentaculum tali. It is a component type of extra-articular talocalcaneal coalition. We report the case of a 17-year-old boy with symptomatic os sustentaculum with talocalcaneal coalition diagnosed on 99mTc-HDP SPECT/CT. We wish to emphasize on the use of SPECT/CT in not only characterizing the ossicle morphologically, but also for evaluation of this anatomical variant as an active source of pain in the absence of a more common cause of pain in young physically active patients.
Quality and Safety in Healthcare, Part LXXVII
Authors: Harolds Jay A. , Miller Laura B. 
Published: September 2020

Abstract
The chief nursing officer serves in multiple roles, but among the most important are being the chief administrator for the division of nursing, the chief voice in the organization to engage and empower nurses as professionals, and a major leader for increasing patient satisfaction, quality, and safety. Each of these roles has overlapping responsibilities, and failure in any one of could result in failure in all of them. If all of these roles are done well, the value of the care rendered by the healthcare organization will be substantially increased.
Abnormal FDG Uptake on PET/CT Due to Periosteal Reaction Caused by Hypervitaminosis D in a Pediatric Patient
Authors: Liu Jun , Wang Wei , Yang Jigang 
Published: September 2020

Abstract
A 7-year-old boy presented with diffuse bone pain. FDG PET/CT was performed to find the possible underlying malignant cause of hypercalcemia. The images demonstrated multiple foci of abnormal FDG activity at the sites of periosteal reaction. In addition, calcium deposit was noted in the basal ganglia, stomach, and the colon. History taking revealed that the patient had routinely taken an over-the-counter “supplement” that contains a high dose of vitamin D. One week after calcitonin therapy and stopping the supplement, the patient became symptom free. This case suggests that hypervitaminosis D might cause hypermetabolic periosteal reaction on FDG PET/CT imaging.
Incidental Metastatic Melanoma Identified on 18F-FDOPA PET/CT With Confirmation by Histology
Authors: Zhang-Yin Jules , Jublanc Christel , Aouidad Iman , Montravers Françoise , Talbot Jean-Noël 
Published: September 2020

Abstract
A 47-year-old woman with a history of surgically treated abdominal paraganglioma and left thigh melanoma underwent an 18F-FDOPA PET/CT for suspected locoregional recurrence of paraganglioma. 18F-FDOPA PET/CT disconfirmed this recurrence but revealed 2 FDOPA-avid left inguinal lymph nodes, confirmed on a subsequent 18F-FDG PET/CT. Excision and pathology characterized these lymph nodes as melanoma metastases. 18F-FDOPA PET/CT is a widely used and valuable tool in the assessment of paraganglioma, both for staging and recurrence detection. Uptake of FDOPA has only rarely been documented in metastatic melanoma that could be a pitfall for detecting neuroendocrine tumors.