bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface Pressure a More Skillful Predictor of Normalized Hurricane Damage than Maximum Sustained Wind
Authors: Klotzbach Philip J. , Bell Michael M. , Bowen Steven G. , Gibney Ethan J. , Knapp Kenneth R. , Schreck Carl J. 
Published: January 2020

AbstractAtlantic hurricane seasons have a long history of causing significant financial impacts, with Harvey, Irma, Maria, Florence, and Michael combining to incur more than 345 billion USD in direct economic damage during 2017–2018. While Michael’s damage was primarily wind and storm surge-driven, Florence’s and Harvey’s damage was predominantly rainfall and inland flood-driven. Several revised scales have been proposed to replace the Saffir–Simpson Hurricane Wind Scale (SSHWS), which currently only categorizes the hurricane wind threat, while not explicitly handling the totality of storm impacts including storm surge and rainfall. However, most of these newly-proposed scales are not easily calculated in real-time, nor can they be reliably calculated historically. In particular, they depend on storm wind radii, which remain very uncertain. Herein, we analyze the relationship between normalized historical damage caused by continental United States (CONUS) landfalling hurricanes from 1900–2018 with both maximum sustained wind speed (Vmax) and minimum sea level pressure (MSLP). We show that MSLP is a more skillful predictor of normalized damage than Vmax, with a significantly higher rank correlation between normalized damage and MSLP (rrank = 0.77) than between normalized damage and Vmax (rrank = 0.66) for all CONUS landfalling hurricanes. MSLP has served as a much better predictor of hurricane damage in recent years than Vmax, with large hurricanes such as Ike (2008) and Sandy (2012) causing much more damage than anticipated from their SSHWS ranking. MSLP is also a more accurately-measured quantity than is Vmax, making it an ideal quantity for evaluating a hurricane’s potential damage.
Intake of sugar sweetened soft drinks among adolescents: Trends and social inequality in Denmark 2002-2018
Authors: Holstein Bjørn E. , Damsgaard Mogens Trab , Due Pernille , Krølner Rikke Fredenslund , Pedersen Trine Pagh , Rasmussen Mette 
Published: January 2020

Background: Intake of sugar sweetened soft drinks (SSSD) has decreased among adolescents, but trends in social inequality in SSSD intake are unknown. Aim: Examine trends in social inequality in SSSD intake among adolescents in Denmark during 2002–2018. Methods: Five Health Behaviour in School-aged Children surveys with data on SSSD intake and parents’ occupational social class (OSC) from nationally representative samples of 11, 13 and 15 year olds, n =20,112. Results: The overall prevalence of daily SSSD intake decreased from 10.1% in 2002 to 6.4% in 2018. The prevalence decreased in both high OSC (from 8% to 5%) and middle OSC (from 10% to 6%) but remained around 12% in low OSC. The odds ratio (OR) estimates of low compared with high OSC increased over the years around an overall OR of 2.01 (1.74–2.34). Conclusions: Danish adolescents’ SSSD intake decreased during 2002–2018 and was higher the lower the parents’ OSC. Thus, social inequality increased during 2002–2018.
Perspectives of elders and their adult children of Black and minority ethnic heritage on end-of-life conversations: A meta-ethnography
Authors: De Souza Joanna , Gillett Karen , Froggatt Katherine , Walshe Catherine 
Published: January 2020

Background: People of Black and minority ethnic heritage are more likely to die receiving life supporting measures and less likely to die at home. End-of-life care decision making often involves adult children as advance care planning is uncommon in these communities. Physicians report family distress as being a major factor in continuing with futile care. Aim: To develop a deeper understanding of the perspectives of elders of Black and minority ethnic heritage and their children, about end-of-life conversations that take place within the family, using a meta-ethnographic approach Design: Systematic interpretive exploration using the process of meta-ethnography was utilised. Data sources: CINAHL, MEDLINE, PubMed and PsycINFO databases were searched. Inclusion criteria included studies published between 2005 and 2019 and studies of conversations between ethnic minority elders and family about end-of-life care. Citation snowballing was used to ensure all appropriate references were identified. A total of 13 studies met the inclusion criteria and required quality level using Critical Appraisal Skills Programme. Results: The following four storylines were constructed: ‘My family will carry out everything for me; it is trust’; ‘No Mum, don’t talk like that’; ‘I leave it in God’s hands’; and ‘Who’s going to look after us?’ The synthesis reflected the dichotomous balance of trust and burden avoidance that characterises the perspectives of Black and minority ethnic elders to end-of-life care planning with their children.
Grip strength and pen pressure are not key contributors to handwriting difficulties in children with developmental coordination disorder
Authors: Prunty Mellissa M , Pratt Anna , Raman Evren , Simmons Laura , Steele-Bobat Fahyma 
Published: January 2020

Introduction Children with developmental coordination disorder have significant difficulties with handwriting. Factors such as hand grip strength and pen pressure are often assumed by clinicians to play a role, although empirical evidence is lacking. The aim of this study was to measure grip strength and pen pressure to examine their relationships with handwriting performance in children with developmental coordination disorder. Method Sixteen 8–14-year-old children with developmental coordination disorder were compared with 20 typically developing age- and gender-matched controls. Palmar, pinch and tripod grip strength were measured using hand dynamometers. The mean pressure exerted on a writing tablet by the pen was obtained during a handwriting task. Group comparisons were made and correlations conducted between grip strength and pen pressure and a range of handwriting product and process measures. Results There were no group differences on the three measures of grip strength. However, the developmental coordination disorder group exerted less pressure on the writing surface compared to typically developing peers. There were no significant correlations between grip strength or pen pressure and handwriting performance in children with developmental coordination disorder. Conclusion Clinicians should be cautious when using measures of grip strength or pen pressure to inform them about aspects of handwriting skill in children with developmental coordination disorder.
Is “extreme” bladder neck preservation in robot-assisted radical prostatectomy a safe procedure?
Authors: Dal Moro Fabrizio , Zazzara Michele , Morlacco Alessandro , Gardiman Marina Paola , Costa Giovanni , Zattoni Fabio 
Published: January 2020

Introduction: The aim was to investigate the surgical and pathological outcomes of an “extreme” bladder neck preservation in prostate cancer patients treated with robotic radical prostatectomy. The greatest concern about the “extreme” bladder neck preservation is the potential risk of creating a positive surgical margin at the level of bladder neck. Materials and methods: We prospectively collected data from 88 patients with diagnosed prostate cancer who underwent robotic radical prostatectomy with “‘extreme’ bladder neck preservation.” All surgical procedures were performed by the same expert surgeon (F.D.M.). In this study, “‘extreme’ bladder neck preservation” was considered when the length of the spared intraprostatic segment of bladder neck was ⩾1 cm. We compared the histopathologic data with those of a homogeneous similar cohort of 88 consecutive patients who underwent robotic radical prostatectomy without bladder neck preservation. Results: The two groups analyzed were comparable according to clinical and pathological characteristics. A positive surgical margin at the level of bladder neck was found in five (5.7%) cases in the “extreme” bladder neck preservation group and in six cases (6.8%) in the no–bladder neck preservation group. The prostatic base was involved by neoplasia in 14 and 19 patients (15.9% and 21.6%, respectively); of these, five (35.7%) and six (31.6%) had positive surgical margin at the level of bladder neck, respectively. The pathological staging in positive surgical margin at the level of bladder neck patients was pT3 in five (100%) cases in the “extreme” bladder neck preservation group and in four (66.7%) cases when we decided not to preserve the bladder neck. Conclusion: We demonstrated that “extreme” bladder neck preservation is a safe oncological procedure with similar pathologic findings of a comparable no–bladder neck preservation series. Positive surgical margins at the level of bladder neck are linked to neoplasia with adverse pathological features, rather than the “extreme” bladder neck preservation procedure.
Repeatability of ultrasound examination of the optic nerve sheath diameter in the adult cat: comparison between healthy cats and cats suffering from presumed intracranial hypertension
Authors: Evangelisti Maria Antonietta , Carta Giovanni , Burrai Giovanni P , Pinna Parpaglia Maria Luisa , Cubeddu Francesca , Ballocco Isabella , Puggioni Antonella , Manunta Maria Lucia 
Published: January 2020

Objectives The objectives of this study were to test: (1) the repeatability of ultrasonographic examination of the optic nerve sheath diameter (ONSD) in the cat; (2) the association between the ONSD and age, sex and body weight in healthy cats; and (3) the difference in the ONSD between healthy cats and those suffering from presumed intracranial hypertension (ICH). Methods This study had a prospective, blinded, observational cross-sectional study design. Two groups of animals were considered: healthy cats (group A) and cats with a diagnosis of presumed ICH (group B). The ONSD was evaluated, measured and compared between the two groups via an ultrasonographic transpalpebral approach. Repeatability of the procedure was evaluated through the intraclass correlation coefficient (ICC). Data were statistically compared using the Student’s t-test and linear regression analysis. Results A strong inter- and intraobserver ICC indicating good repeatability was observed. The interobserver ICC was 0.965 ( P  <0.05) for the right eye and 0.956 ( P  <0.05) for the left eye. The intraobserver ICC was 0.988 ( P  <0.05) and 0.984 ( P  <0.05) for the right and left eyes, respectively. In healthy cats the mean ± SD ONSD was 1.23 ± 0.11 mm (range 1–1.47 mm) and 1.23 ± 0.10 (range 1–1.4 mm) for right and left eyes, respectively. The ONSD was not related to sex or weight; a weak relationship was observed with age. In group B, the mean ONSD was 1.68 ± 0.13 mm (range 1.5–1.9 mm) and 1.61 ± 0.15 mm (range 1.4–1.9 mm) for the right and left eyes, respectively. In group B, the ONSD was statistically significantly larger than in group A, the healthy cats ( P  <0.001). Conclusions and relevance The transpalpebral ultrasonographic technique is a non-invasive, feasible and reproducible method to measure ONSD both in healthy cats and in cats suffering from suspected ICH.
A retrospective analysis of NIH-funded digital health research using social media platforms
Authors: Nebeker Camille , Dunseath Sarah E. , Linares-Orozco Rubi 
Published: January 2020

Objective Social network platforms are increasingly used in digital health research. Our study aimed to 1. qualify and quantify the use of social media platforms in health research supported by the National Institutes of Health (NIH) and document changes occurring between 2011 and 2017 and 2. examine whether institutions hosting these studies provided public-facing guidelines on how to conduct ethical social media health research. Methods The NIH RePORTER (Research Portfolio Online Reporting Tools) database was searched to identify research utilizing Instagram, Pinterest, Facebook, or Twitter. Studies included used social media for observational research, recruitment, intervention delivery or to assess social media as an effective research tool. Abstracts were qualitatively analyzed to describe the population and health topic by year. Websites of organizations receiving funding for this research were searched to identify whether guidance or policy existed. Results Studies ( n = 105) were organized by population targeted and health focus. Main “Health” themes were labeled: 1. substance use, 2. disease/diagnosis, 3. psychiatry/mental health, and 4. weight and physical activity. The populations most involved included adolescents and young adults, and men who have sex with men. The number of research studies using social media increased approximately 590% between 2011 and 2017. Studies were linked to 56 organizations of which 21% ( n = 12) provided some accessible guidance with 79% ( n = 44) offering no guidance specific to social media health research. Conclusions Social media research is conducted with vulnerable populations that are traditionally difficult to reach. There is a compelling need for resources designed to support ethical and responsible social media-enabled research to enable this research to be carried out safely.
Effect of cementing on pulmonary arterial pressure in vertebroplasty: A comparison of two techniques
Authors: Kochai Alauddin , Enercan Meric , Kahraman Sinan , Ozturk Cagatay , Hamzaoglu Azmi 
Published: January 2020

Background: Increase in intraosseous pressure and displacement of bone marrow contents leading to fat embolism and hypotension during cement injection in vertebroplasty (VP). We aimed to compare the effect of low and high viscosity cements during VP on pulmonary arterial pressure (PAP) with different cannula. Materials and Methods: Fifty-two patients having multilevel VP due to osteoporotic vertebral compression fractures were randomly treated either by a high viscosity cement (group A, n = 27 patients) and 2.8 mm cannula or a low viscosity cement (group B, n = 25 patients) injected through 4.2 mm cannula. PAP was measured by standard echocardiography and blood d-dimer values were recorded preoperatively, 24 h and third day after operation. Results: Mean age was 69 (62–87) years in group A and 70 (64–88) years in group B, and sex and comorbidities were similar. Average number of augmented levels was 5.4 in group A and 5.7 in group B. Preoperative mean PAP was 33 mm/Hg in group A, elevated to 41 mm/Hg on first day, and decreased to 36 mm/Hg on third day. The mean PAP in group B was 35 mm/Hg preoperatively, 51 mm/Hg on first day and 46 mm/Hg on third day ( p < 0.05). The average blood d-dimer values in group A increased from 2.1 µg/mL to 2.3 µg/mL and in group B from 2.2 µg/mL to 4.2 µg/mL. Conclusion: The finding of this study showed that high viscosity cement injected through a narrower cannula results in lesser PAP increase and d-dimer levels when compared to low viscosity cement injected through a wider cannula. Higher PAP and d-dimer level may show possible thromboembolism. This finding may give spine surgeons to reconsider their choice of cement type and cannula size.
Strain partitioning in host rock controls light rare earth element release from allanite-(Ce) in subduction zones
Authors: Corti Luca , Zanoni Davide , Gatta G. Diego , Zucali Michele 
Published: January 2020

AbstractCombined microstructural, mineral chemical, X-ray maps and X-ray single-crystal diffraction analyses are used to reveal the behaviour of individual grains of magmatic allanite relicts hosted in variably deformed metagranitoids at Lago della Vecchia (inner part of the Sesia-Lanzo Zone, Western Alps, Europe), which experienced high-pressure and low-temperature metamorphism during the Alpine subduction. X-ray single-crystal diffraction shows that none of the allanite crystals, irrespective of the strain state of the host rock, record any evidence of plastic deformation (i.e. intracrystalline deformation), as indicated by the shape of the Bragg diffraction spots, the atomic site positions, and their displacement around the centre of gravity. On the contrary, strong plastic deformation affected matrix minerals, such as quartz, white mica and feldspar of the hosting rocks, during the development of the Alpine eclogitic- and blueschist-facies metamorphism. Despite the strain-free atomic structures of allanite, different patterns of chemical zoning, as a function of strain accumulated in the rock matrix, are observed. As allanite occurs in magmatic and metamorphic rocks and it is stable at high-pressure and low-temperature conditions, we infer that allanite could behave as one of the main carriers of light rare earth elements into the mantle wedge during subduction of continental crust. In particular, the release of light rare earth elements from allanite, under high-pressure conditions in subduction zones, is facilitated by high strain accumulated in the host rock.
Recapitulation of posttransfusion purpura by cross-strain platelet immunization in mice
Authors: Bougie Daniel W. , Sutton Jessica , Aster Richard H. 
Published: January 2020

Abstract
Posttransfusion purpura (PTP) is an uncommon but life-threatening condition characterized by profound thrombocytopenia occurring ∼1 week after a blood transfusion. The hallmark of PTP is a potent immunoglobulin G antibody specific for a transfused platelet-specific alloantigen, usually located on glycoprotein IIb/IIIa (GPIIb/IIIa; αIIb/β3 integrin). It is widely thought that this alloantibody somehow causes the thrombocytopenia, despite absence from host platelets of the alloantigen for which it is specific. In studies described here, we found that cross-strain platelet immunization in mice commonly induces GPIIb/IIIa-specific alloantibodies combined with platelet-specific autoantibodies and varying degrees of thrombocytopenia, and we identified 1 strain combination (129S1Svlm/PWKPhJ) in which 95% of immunized mice made both types of antibody and developed severe thrombocytopenia. There was a strong inverse correlation between autoantibody strength and platelet decline (P &lt; .0001) and plasma from mice that produced autoantibodies caused thrombocytopenia when transfused to syngeneic animals, arguing that autoantibodies were the cause of thrombocytopenia. The findings define a model in which a routine alloimmune response to platelets regularly transitions to an autoimmune reaction capable of causing severe thrombocytopenia and support the hypothesis that PTP is an autoimmune disorder.
Euglycemic diabetic ketoacidosis caused by canagliflozin: a case report
Authors: Fukuda Masafumi , Nabeta Masakazu , Muta Takanori , Fukami Kei , Takasu Osamu 
Published: January 2020

Abstract
Background
Diabetic ketoacidosis (DKA) is seen relatively frequently in the emergency department (ED). DKA is characterized by hyperglycemia, acidosis, and ketonemia, and sodium glucose transporter 2 inhibitors (SGLT2i) represent a new diabetes medication that has been associated with euglycemic DKA (eu-DKA).

Case presentation
A 71-year-old female who was being treated for type 2 diabetes with canagliflozin, metformin, and saxagliptin orally presented to the ED for evaluation of reduced oral intake, malaise, nausea, and abdominal pain. Although her blood glucose was not severely elevated (259 mg/dL), there was notable ketoacidosis (pH 6.89; CO2, 11.4 mmHg; HCO3, 1.9 mEq/L; base excess, − 31.3 mmol/L; 3-hydroxybutyric acid > 10,000 μmol/L) was observed. The uncontrolled acidosis improved following 3 days of continuous renal replacement therapy, but elevated urinary glucose continued for more than 10 days. Ringer’s lactated fluid supplementation was continued for management of polyurea and glucosuria. Urinary glucose turned negative on day 16, and there was improvement in the patient’s overall state; hence, she was discharged on day 18.

Conclusion
Although it is difficult to diagnose eu-DKA because of the absence of substantial blood glucose abnormalities in the ED, there is a need to consider eu-DKA when evaluating acidosis in a patient treated with SGLT2i. Moreover, even after discontinuing the SGLT2i, attention should be given to the possibility of continuing glucosuria. Regular measurements of urinary glucose should be obtained, and the patient should be monitored for dehydration.
A two-pore channel protein required for regulating mTORC1 activity on starvation
Authors: Chang Fu-Sheng , Wang Yuntao , Dmitriev Phillip , Gross Julian , Galione Antony , Pears Catherine 
Published: January 2020

AbstractBackgroundTwo-pore channels (TPCs) release Ca2+from acidic intracellular stores and are implicated in a number of diseases, but their role in development is unclear. The social amoebaDictyostelium discoideumproliferates as single cells that aggregate to form a multicellular organism on starvation. Starvation is sensed by the mTORC1 complex which, like TPC proteins, is found on acidic vesicles. Here, we address the role of TPCs in development and under starvation.ResultsWe report that disruption of the gene encoding the singleDictyosteliumTPC protein, TPC2, leads to a delay in early development and prolonged growth in culture with delayed expression of early developmental genes, although a rapid starvation-induced increase in autophagy is still apparent. Ca2+signals induced by extracellular cAMP are delayed in developingtpc2−cells, and aggregation shows increased sensitivity to weak bases, consistent with reduced acidity of the vesicles. In mammalian cells, the mTORC1 protein kinase has been proposed to suppress TPC channel opening. Here, we show a reciprocal effect astpc2−cells show an increased level of phosphorylation of an mTORC1 substrate, 4E-BP1. mTORC1 inhibition reverses the prolonged growth and increases the efficiency of aggregation oftpc2−cells.ConclusionTPC2 is required for efficient growth development transition inDictyosteliumand acts through modulation of mTORC1 activity revealing a novel mode of regulation.
Burden and antimicrobial resistance of S. aureus in dairy farms in Mekelle, Northern Ethiopia
Authors: Kalayu Alem Abrha , Woldetsadik Daniel Asrat , Woldeamanuel Yimtubezinash , Wang Shu-Hua , Gebreyes Wondwossen A. , Teferi Tadesse 
Published: January 2020

Abstract
Background
Staphylococcus aureus is a frequent colonizer of human and several animal species, including dairy cows. It is the most common cause of intramammary infections in dairy cows. Its public health importance increases inline to the continuous emergence of drug-resistant strains; such as Methicillin-resistant S. aureus (MRSA). Indeed, the recent emergence of human and veterinary adapted MRSA demands serious attention. The aim of this study was to determine the burden and drug resistance pattern of S. aureus in dairy farms in Mekelle and determine the molecular characteristics of MRSA.

Results
This study was done on 385 lactating dairy cows and 71 dairy farmers. The ages of the cows and farmworkers were between 3 and 14 and 17–63 years respectively. S. aureus was isolated from 12.5% of cows and 31% of farmworkers. Highest resistance was observed for penicillin (> 90%) followed by tetracycline (32–35%) and trimethoprim-sulphamethoxazole (10–27%). But no resistance was observed for vancomycin, daptomycin, and rifampin. Only one isolate was MRSA both phenotypically and harboring mecA. This isolate was from nasal of a farmworker and was MRSA SCCmec Iva, spa type t064 of CC8. Multi-drug resistance was observed in 6.2% of cow isolates and 13.6% of nasal isolates.

Conclusions
In this study, S. aureus infected 12.5% of dairy cows and colonized 31% of farmworkers. Except for penicillin, resistance to other drugs was rare. Although no MRSA was found from dairy cows the existence of the human and animal adapted and globally spread strain, MRSA SCCmec IVa spa t064, warrants for a coordinated action to tackle AMR in both human and veterinary in the country.