bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wind driven dragonfly algorithm for global optimization
Authors: Zhong Lianlian , Zhou Yongquan , Luo Qifang , Zhong Keyu 
Published: October 2020

SummaryDragonfly algorithm (DA) is a new swarm intelligence optimization algorithm based on the static and dynamic swarm behavior of dragonflies. The algorithm has the characteristics of simple structure, strong search ability, easy implementation, and strong robustness. However, the DA algorithm itself also has insufficient solution accuracy and slow convergence speed. The Wind Driven Optimization algorithm (WDO) has the characteristics of fast convergence speed and strong global search capability. So as to improve the optimization performance of the DA algorithm and avoid premature convergence, the speed of the WDO is introduced into the later calculation of the algorithm iteration, which speeds up the convergence speed of the global optimal solution. This paper proposes a dragonfly algorithm based on wind driven (WDDA), that is to reduce the blindness of the dragonfly algorithm search, improve the solution accuracy and convergence speed, to improve the overall optimization performance of the algorithm. The 23 benchmark test functions and one engineering example for optimization and comparison experiments. The experimental results show that WDDA algorithm has better performance in function optimization.
Structural, Photophysical, and Photobiological Studies on BODIPY‐Anthracene Dyads
Authors: Callaghan Susan , Vindstad Benedikte E. , Flanagan Keith J. , Melø Thor B. , Lindgren Mikael , Grenstad Kristin , Gederaas Odrun A. , Senge Mathias O. 
Published: October 2020

AbstractWe report the structural, photophysical, and photobiological properties of a promising BODIPY‐anthracene dyad (BAD) that was previously shown to induce a therapeutic effect against MDA‐MB‐468 cells. The BODIPY was synthesized and its crystal structure was elucidated. We further investigate the potential of this molecule as a versatile photosensitizer for photodynamic therapy against AY27 and F98 cancer cell models. Both necrosis and apoptosis were found to play a role in cell death and G1 phase arrestation was observed following PDT. From time‐resolved spectroscopic analysis of absorbance and luminescence, it was found that the singlet oxygen quantum yield of the most promising BODIPY‐anthracene dyad is high (>70 %) and originates from a triplet state. Interestingly, despite the efficient PDT effect, long‐lived triplet states or singlet oxygen formation were not observed when water (or D2O) was used as the solvent but were readily observed in solvents such as MeOH and EtOH.
Nickel is a Different Pickle: Trends in Water Oxidation Catalysis for Molecular Nickel Complexes
Authors: Hessels Joeri , Masferrer‐Rius Eduard , Yu Fengshou , Detz Remko J. , Klein Gebbink Robertus J. M. , Reek Joost N. H. 
Published: October 2020

AbstractThe development of novel water oxidation catalysts is important in the context of renewable fuels production. Ligand design is one of the key tools to improve the activity and stability of molecular catalysts. The establishment of ligand design rules can facilitate the development of improved molecular catalysts. In this paper it is shown that chemical oxidants can be used to probe oxygen evolution activity for nickel‐based systems, and trends are reported that can improve future ligand design. Interestingly, different ligand effects were observed in comparison to other first‐row transition metal complexes. For example, nickel complexes with secondary amine donors were more active than with tertiary amine donors, which is the opposite for iron complexes. The incorporation of imine donor groups in a cyclam ligand resulted in the fastest and most durable nickel catalyst of our series, achieving oxygen evolution turnover numbers up to 380 and turnover frequencies up to 68 min−1 in a pH 5.0 acetate buffer using Oxone as oxidant. Initial kinetic experiments with this catalyst revealed a first order in chemical oxidant and a half order in catalyst. This implies a rate‐determining oxidation step from a dimeric species that needs to break up to generate the active catalyst. These findings lay the foundation for the rational design of molecular nickel catalysts for water oxidation and highlight that catalyst design rules are not generally applicable for different metals.
Diagnostic significance of flow cytometry scales in diagnostics of myelodysplastic syndromes
Authors: Davydova Yulia O. , Parovichnikova Elena N. , Galtseva Irina V. , Kokhno Alina V. , Dvirnyk Valentina N. , Kovrigina Alla M. , Obukhova Tatyana N. , Kapranov Nikolay M. , Nikiforova Ksenia A. , Glinkina Svetlana A. , Troitskaya Vera V. , Mikhailova Elena A. , Fidarova Zalina T. , Moiseeva Tatyana N. , Lukina Elena A. , Tsvetaeva Nina V. , Nikulina Olga F. , Kuzmina Larisa A. , Savchenko Valeriy G. 
Published: October 2020

AbstractBackgroundMyelodysplastic syndromes (MDS) can present a challenge for clinicians. Multicolor flow cytometry (MFC) can aid in establishing a diagnosis. The aim of this study was to determine the optimal MFC approach for MDS.MethodsThe study included 102 MDS (39 low‐grade MDS), 83 cytopenic patients without myeloid neoplastic disorders (control group), and 35 healthy donors. Bone marrow was analyzed using a six‐color MFC. Analysis was conducted according to the “Ogata score,” “Wells score,” and the integrated flow cytometry (iFC) score.ResultsThe respective sensitivity and specificity values were 77.5% and 90.4% for the Ogata score, 79.4% and 81.9% for the Wells score, and 87.3% and 87.6% for the iFC score. Specificity was not 100% due to deviations of MFC parameters in the control group. Patients with paroxysmal nocturnal hemoglobinuria (PNH) had higher levels of CD34+CD7+ myeloid cells than donors. Aplastic anemia and PNH were characterized by a high proportion of CD56+ cells among CD34+ precursors and neutrophils. The proportion of MDS‐related features increased with the progression of MDS. The highest number of CD34+ blasts was found in MDS with excess blasts. MDS with isolated del(5q) was characterized by a high proportion of CD34+CD7+ cells and low granularity of neutrophils. In 39 low‐grade MDS, the sensitivities were 53.8%, 61.5%, and 71.8% for Ogata score, Wells score, and iFC, respectively.ConclusionThe results support iFC as a useful diagnostic tool in MDS.
Gold Nanoparticles/Biphenol–biphenoquinone for Ultra‐trace Voltammetric Determination of Captopril
Authors: Shahbakhsh M. , Hashemzaei Z. , Narouie S. , Shahbakhsh Y. , Noroozifar M. 
Published: October 2020

AbstractThis study aims to synthesize gold nanoparticles/biphenol–biphenoquinone (AuNPs−BOH−BQ) and to study its application as a novel heterogeneous electron transfer mediator to modify carbon paste electrode (CPE/Au NPs−BOH−BQ) for ultra‐trace determination of captopril (CP). Characterization results show well dispersed Au NPs with sizes in the range of 8.0–10.5 nm. Under optimized conditions, the calibration plot was linear from 1 to 5×104 nM (two segments, 1–150 nM and 0.15–50.0 μM) and the detection limit was calculated to be 0.4 nM (S/N=3). Finally, the suggested sensor showed stable and reliable responses to CP in CP pharmaceutical tablet and urine samples.
Application of MWCNT/Ag‐Pt Nanocomposite Modified GCE for the Detection of Nevirapine in Pharmaceutical Formulation and Biological Samples
Authors: Okumu Fredrick O. , Silwana Bongiwe , Matoetoe Mangaka C. 
Published: October 2020

AbstractA study of nanosensor comprising of a glassy carbon electrode modified with a composite of multiwall carbon nanotube (MWCNT) and bimetallic (Ag‐PtNPs) for the determination of Nevirapine. The GCE/MWCNT/Ag‐PtNPs sensor had remarkable electrocatalytic properties with enhanced response towards Nevirapine under optimized conditions. The platform electrochemical characterisation in 0.01 M NaOH solution, with cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) is detailed. The limit of the detection (LOD) was 0.021 μM. The nanosensor was validated for real sample study using spiked pharmaceutical dose form, milk and urine samples, which showed acceptable recoveries (90‐ 112 %), good precision (RSD=3.3 %, N=3), reproducibility (RSD=4.3 %) and excellent selectivity towards Nevirapine from studied interferents.
Graphene‐AuNP Enhanced Inkjet‐printed Silver Nanoparticle Paper Electrodes for the Detection of Nickel(II)‐Dimethylglyoxime [Ni(dmgH2)] Complexes by Adsorptive Cathodic Stripping Voltammetry (AdCSV)
Authors: Pokpas Keagan , Jahed Nazeem , McDonald Earl , Bezuidenhout Petrone , Smith Suzanne , Land Kevin , Iwuoha Emmanuel 
Published: October 2020

AbstractThe development of low‐cost, disposable electrode materials has been at the forefront of sensor technology in recent decades. Paper, offers possibilities for multi‐functional, disposable and economically friendly sensing capabilities and has proved to be a suitable reagent storage and substrate material in paper‐based analytical devices (PADs). In this work, we report a simple inkjet printing procedure on photographic paper for the fabrication of single analyte electrochemical sensors. A three‐electrode system, consisting of a 3 mm diameter working electrode (WE), a counter electrode (CE) and a reference electrode (RE) were prepared by inkjet printing of silver conductive inks for comparison to common commercial screen printed electrode (SPE) brands. In a second step, carbon coating and modification of the working electrode surface with an electrochemically reduced graphene oxide, gold nanoparticle (ERGO‐AuNP) film, to improve electrode sensitivity and selectivity was employed. Improved electron‐transfer kinetics, increased active surface area and enhanced catalytic properties were achieved due to the ERGO‐AuNP layer inclusion. Electrical and topographical characterization of the printed layers was performed in the fabrication process. Printing of Ag−NP ink showed good resistivity (1.8–6.3 Ω) on photographic paper. The prepared printed paper‐based electrodes (PPE) offer a quantitative analysis of Ni(II), based on the accumulation of Ni(dmgH)2 complexes at the modified electrode surface by square‐wave adsorptive cathodic stripping voltammetry (SW‐AdCSV). This study offers the first investigation on the feasibility of adsorptive electrochemical sensing methods at porous cellulose paper‐based substrates. Instrumental parameters including deposition potential and deposition time were optimized for both electrochemical sensors. Improved sensitivities were achieved at the modified integrated electrodes over the unmodified derivate with a limit of detection (LOD) of 32.19 μg L−1 achieved for the ERGO‐AuNP−CC−Ag−PPE. This is well below the EPA and WHO standards of 0.1 mg L−1 or 0.1 ppm for Ni2+ in drinking water.
A comprehensive analysis of the achievable throughput in interference‐limited wireless‐powered networks with nonlinear energy harvester
Authors: Badarneh Osamah S. 
Published: October 2020

AbstractIn this article, a comprehensive analysis of the achievable throughput in interference‐limited wireless‐powered networks (WPNs) with nonlinear energy harvester is presented. In particular, we consider a WPN in which an energy‐constrained transmitter access point (AP) harvests radio‐frequency (RF) energy transferred by a power beacon (PB) before data transmission to destination node. The AP and PB are equipped with multiantenna, whereas the destination node and interferers nodes are equipped with a single antenna. The channel between the PB and the AP experiences Nakagami‐m fading, while the channels between the AP and the destination, and the interferers nodes and the destination are assumed to follow composite fading channels. For this system, we derive novel analytical expressions for the achievable capacity under different transmission schemes, namely optimal rate adaptation, effective capacity, optimal power and rate adaptation, channel inversion with fixed rate, truncated channel inversion with fixed rate, and effective capacity. The derived expressions are then employed to evaluate the performance of the achievable throughput under different system and channel conditions. The analytical analyses are validated through numerical and Monte‐Carlo simulations.
Waste cooking oil as an efficient solvent for the production of urea precursor ammonium carbamate from carbon dioxide
Authors: Sachin Eledathu Kuriachan , Ramachandran Andimuthu , Palanivelu Kandasamy , Syrtsova Daria Aleksandrovna , Teplyakov Vladimir Vasilievich , Kunalan Shankar 
Published: October 2020

AbstractCarbon sequestration and utilization are currently gaining attention as they help to reduce the emission of greenhouse gases in the atmosphere. This study explores the possibility of using carbon dioxide as a feedstock for the production of ammonium carbamate, a precursor molecule for urea production. Waste cooking oil was used as the indispensable nonaqueous medium for the formation of pure ammonium carbamate. This makes the process completely ecofriendly and cost‐effective. A continuous process of ammonium carbamate production at 20°C results in 88.86% consumption of carbon dioxide. The highest yield of ammonium carbamate was achieved at an NH3/CO2 ratio of 2.5. A three‐stage setup was also found to increase the yield of ammonium carbamate. The reusability of oil after each cycle was checked and it was found that the formation of the product is comparatively less compared to the previous cycle. Lower yield was observed when the same experiment was carried out with fresh oil (sunflower oil). The exit gas from the process was found to be rich in ammonia that can be further used for the production of struvite, a phosphate fertilizer. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd.
Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts
Authors: Colaianni Graziana , Errede Mariella , Sanesi Lorenzo , Notarnicola Angela , Celi Monica , Zerlotin Roberta , Storlino Giuseppina , Pignataro Patrizia , Oranger Angela , Pesce Vito , Tarantino Umberto , Moretti Biagio , Grano Maria 
Published: October 2020

ABSTRACT
Irisin is a myokine produced by skeletal muscle during exercise in both mice and humans. We previously showed that irisin treatment ameliorates immobility-induced osteoporosis and muscular atrophy in mice. Data in humans showed a positive association between irisin and bone mineral density (BMD) in athletes and a population of healthy children. However, the role of this myokine regarding the state of muscle and bone in the same population remained to be determined. For this purpose, 62 patients (age 68.71 ± 12.31 years) undergoing total hip or knee replacement were recruited. Our results showed that irisin serum levels negatively correlated with age (R = −0.515; p = .000018) and positively correlated with femoral BMD (R = 0.619; p = .001) and vertebral BMD (R = 0.201; p = .0001). Irisin was also positively associated with Fndc5 mRNA in muscle biopsies (R = 0.248; p = .016), as well as with Osteocalcin (Ocn) mRNA in bone biopsies (R = 0.708; p = .006). In skeletal muscle, FNDC5 positive fibers positively correlate with BMD of total femur (R = 0.765; p = .0014) and BMD of femoral neck (R = 0.575; p = .031), Interestingly, by analyzing patients divided by their T-score, we found lower irisin levels (p = .0011) in patients with osteopenia/osteoporosis (OP) compared to healthy controls matched for age and sex. By analyzing the senescence marker p21, we found a significant increase of its mRNA expression in the bone biopsies of OP patients compared to control ones. Therefore, we investigated in vitro whether rec-irisin had a direct effect on this senescence marker, showing that p21 mRNA expression was significantly downregulated in osteoblasts by the treatment with irisin. Overall, these results indicate that higher irisin levels are associated with a lower rate of age-related osteoporosis and that irisin could be effective in delaying the osteoblast aging process, suggesting a potential senolytic action of this myokine. © 2020 American Society for Bone and Mineral Research (ASBMR).
“I forgive myself”: The association between self‐criticism, self‐acceptance, and PTSD in women victims of IPV, and the buffering role of self‐efficacy
Authors: Crapolicchio Eleonora , Vezzali Loris , Regalia Camillo 
Published: October 2020

AbstractThe effects of intimate partner violence (IPV) concerning specifically posttraumatic stress disorder (PTSD) symptomatology have been widely demonstrated, but the consequences of abuse are not the same for all victims. We know little about the psychological processes that limit these adverse consequences. Therefore, we explored the association between self‐criticism felt by abused women and their PTSD, and we investigated self‐acceptance as the underlying process explaining this relationship. We also examined self‐efficacy as the protective (moderating) factor. The results indicated that self‐criticism was indirectly associated with greater PTSD via lower self‐acceptance. Critically, the indirect effect only emerged for individuals low in self‐efficacy.
Clinical utility of a newly developed microfluidic device for detecting circulating tumor cells in the blood of patients with pancreatico‐biliary malignancies
Authors: Konno Naoki , Suzuki Rei , Takagi Tadayuki , Sugimoto Mitsuru , Asama Hiroyuki , Sato Yuki , Irie Hiroki , Hikichi Takuto , Ohira Hiromasa 
Published: October 2020

AbstractBackgroundThe development of an optimal screening method is required to improve the prognosis of pancreatico‐biliary (PB) cancers. A recently developed microfluidic device achieved a high diagnostic yield by detecting circulating tumor cells (CTCs) in the blood of cancer patients. We conducted this study to investigate the clinical utility of measuring CTCs in peripheral venous blood to diagnose PB cancer.MethodsSixty‐three subjects were enrolled in this study (29 with pancreatic cancer [PC], 19 with biliary cancer [BC] and 16 non‐tumor controls). Using a microfluidic chip device and image analyzer, circulating blood cells were selected based on their size and immunocytochemistry staining pattern. The primary endpoint was the diagnostic accuracy of CTCs with regard to distinguishing between PB cancer patients and controls. We divided all cases into the training set (n = 32) and validation set (n = 31). The diagnostic accuracy of CTCs, carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA19‐9) were analyzed.ResultsIn both the training set and validation set, CTCs showed the highest diagnostic accuracy (training set: CTCs 90.6%, CA19‐9 90.6%, CEA 65.6%, validation set: CTCs 87.5%, CA19‐9 78.1%, CEA 81.2). Regarding non‐metastatic PC (cStage I‐III, n = 11), CTCs also had the highest diagnostic accuracy among the three markers tested (CTCs: 84.6%, CA19‐9:80.7%, CEA 73.0%).ConclusionsA newly developed microfluidic device could diagnose PB cancers by detecting CTCs. This trial was registered with the UMIN Clinical Trials Registry, no. UMIN000029808.
Lights off, camera on! Laparoscopic cholecystectomy improves outcomes in cirrhotic patients with acute cholecystitis
Authors: Finco Tiago , Firek Matthew , Coimbra Bruno C. , Brenner Megan , Coimbra Raul 
Published: October 2020

AbstractBackgroundThe best surgical approach to treat acute cholecystitis (AC) in cirrhotic patients is controversial. This study aimed to evaluate treatment options in cirrhotic patients with AC. We hypothesized that laparoscopic cholecystectomy (LC) would lead to better clinical outcomes when compared to non‐operative management (NOM) and open cholecystectomy (OC), independent of the severity of liver cirrhosis.MethodsPatients from the National Inpatient Sample diagnosed with AC were stratified into no cirrhosis (NC), compensated cirrhosis (CC), and decompensated cirrhosis (DC) and analyzed according to treatment: NOM, OC, and LC. Primary outcome was in‐hospital mortality. Secondary outcomes included hospital length of stay (HLOS), cost, and surgical complications. Univariate and multivariate analyses using generalized linear models were performed. A P < 0.05 was deemed significant.ResultsOf 1 367 495 AC patients, 49 030 (3.6%) had cirrhosis; 23 260 had CC, and 25 770 had DC. LC (12 080 in CC group and 4840 in DC group) was accompanied by significantly lower mortality, HLOS, complications, and cost when compared to OC and NOM.OC was significantly associated with higher mortality, increased HLOS, total cost, and postoperative complications, independent of the presence or severity of cirrhosis.ConclusionsLC in cirrhotic patients leads to superior outcomes compared to OC and NOM regardless of the severity of cirrhosis.
Early clinical factors predicting the development of critical disease in Japanese patients with COVID‐19: A single‐center, retrospective, observational study
Authors: Higuchi Takatoshi , Nishida Tsutomu , Iwahashi Hiromi , Morimura Osamu , Otani Yasushi , Okauchi Yukiyoshi , Yokoe Masaru , Suzuki Norihiro , Inada Masami , Abe Kinya 
Published: October 2020

AbstractThe factors predicting the progression of coronavirus disease‐2019 (COVID‐19) from mild to moderate to critical are unclear. We retrospectively evaluated risk factors for disease progression in Japanese patients with COVID‐19. Seventy‐four patients with laboratory‐confirmed COVID‐19 were hospitalized in our hospital between February 20, 2020, and June 10, 2020. We excluded asymptomatic, non‐Japanese, and pediatric patients. We divided patients into the stable group and the progression group (PG; requiring mechanical ventilation). We compared the clinical factors. We established the cutoff values (COVs) for significantly different factors via receiver operating characteristic curve analysis and identified risk factors by univariate regression. We enrolled 57 patients with COVID‐19 (median age 52 years, 56.1% male). The median time from symptom onset to admission was 8 days. Seven patients developed critical disease (PG: 12.2%), two (3.5%) of whom died; 50 had stable disease. Univariate logistic analysis identified an elevated lactate dehydrogenase (LDH) level (COV: 309 U/l), a decreased estimated glomerular filtration rate (eGFR; COV: 68 ml/min), lymphocytopenia (COV: 980/μl), and statin use as significantly associated with disease progression. However, in the Cox proportional hazards analysis, lymphocytopenia at admission was not significant. We identified three candidate risk factors for progression to critical COVID‐19 in adult Japanese patients: statin use, elevated LDH level, and decreased eGFR.