bluuebunny/crossref_metadata_2025_split huggingface dataset:
EQ-5D results in stroke survivors: What are they suffering from? Results from the Henan Rural Cohort Study
Authors: Mei Yong-xia , Zhang Zhen-xiang , Wu Hui , Hou Jian , Liu Xiao-tian , Sang Sheng-xiang , Mao Zhen-xing , Zhang Wei-hong , Yang Dong-bin , Wang Chongjian 
Published: August 2020

Abstract
Background Stroke is a major health threat and the leading cause of mortality and disability in China. The aims of this study were to identify the possible influencing factors of health-related quality of life (HRQoL) and its domain-specific contents in stroke patients in rural areas in China. Methods A total of 1709 stroke patients aged from 36 to 79 years from the Henan Rural Cohort Study (n=39259) were included in this study. The Chinese version of the European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L) and visual analogue scale (VAS) were used to evaluate HRQoL in stroke patients. Tobit regression models, generalized linear models and binary logistic regressions models were constructed to determine the potential influencing factors of the EQ-5D utility index, as well as influencing factors of each domains and VAS score.Results The mean utility index and VAS scores of stroke patients were 0.885 (SD, 0.204), and 68.39 (SD, 17.31), respectively. Pain/discomfort (PD, 35.2%) and mobility (MO, 30.4%) were the most frequently reported issues. Regression models revealed that stroke patients who were illiterate; had a low monthly income; reported low physical activity intensity; and had diabetes, anxiety, depression or poor sleep quality had lower utility index and VAS scores. For the different dimensions of the EQ-5D, the influencing factors varied. Conclusion Stroke patients in rural areas had a lower HRQoL than those in urban areas. Factors associated with the EQ-5D utility index as well as each domain and VAS score, need attention. Stroke patients in rural areas need to be managed systematically. Clinical trial registration: The Henan Rural Cohort Study has been registered in the Chinese Clinical Trial Register (Registration Number: ChiCTR-OOC-15006699). Date of registration: 2015-07-06.http://www.chictr.org.cn/showproj.aspx?proj=11375.
Social trust and emotional health in older adults in China: The mediating and moderating role of subjective well-being and subjective social status
Authors: Chen Hongsheng , Zhu Zhenjun 
Published: August 2020

Abstract
Background China is becoming an aging society. The emotional health of the elderly is gaining importance. Social trust is an important factor affecting emotional health, but existing studies have rarely considered the various effects of different types of social trust on elderly emotional health. Few studies have analysed the role of subjective well-being and subjective social status in the relationship between social trust and elderly emotional health.Methods Using the data of the China Labor-force Dynamics Survey 2016 (CLDS 2016) and regression models, this study selected 3767 respondents aged 60 years and above to analyse the impact of social trust on their emotional health. Social trust was divided into three categories: trust in family members, trust in friends, and trust in neighbours. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess emotional health, and the respondents’ self-assessment scores were adjusted.Results Trust in family members was significantly and positively associated with emotional health (coefficient = 2.854, P < 0.01) and subjective well-being (coefficient = 0.189, P < 0.01). Trust in friends was significantly and positively associated with emotional health and subjective well-being (coefficient = 1.703, P < 0.01; coefficient = 0.171, P < 0.01, respectively). Trust in neighbours was significantly and positively associated with emotional health and subjective well-being (coefficient = 1.461, P < 0.01; coefficient = 0.186, P < 0.01; respectively). Subjective well-being effectively reduced the impact of social trust in family, friends, and neighbours on the emotional health of the elderly by 0.378, 0.341, and 0.370, respectively. Trust in family members, friends, and neighbours, significantly and positively affected respondents’ subjective social status (coefficient = 0.115, P < 0.05; coefficient = 0.095, P < 0.05; coefficient = 0.121, P < 0.01, respectively). Subjective social status effectively reduced the impact of social trust in family, friends, and neighbours on the emotional health of the elderly by 0.092, 0.076, and 0.096, respectively. The positive relationship between trust in family members and emotional health was weakened by subjective well-being, and that between trust in neighbours and emotional health was weakened by subjective social status.Conclusions Family relationships play an important role in maintaining the emotional health of the elderly. In response to population ageing, more social policies must be introduced to care for the elderly and help them lead a happy and satisfactory life.
Heart Transplantation of Patients with Ventricular Assist Devices: Impact of Normothermic Ex-Vivo Preservation Using Organ Care System Compared with Cold Storage
Authors: Nurmykhametova Zhuldyz , Kaliyev Rymbay , Lesbekov Timur , Bekbossynov Serik , Bekbossynova Makhabbat , Novikova Svetlana , Medressova Assel , Smagulov Nurlan , Faizov Linar , Samalavicius Robertas , Pya Yuriy 
Published: August 2020

Abstract
Background: Organ Care System (OCS) minimizes the cold ischemic time and allows for optimization of logistics and meticulous recipient preparation. Impact of normothermic ex-vivo preservation using OCS compared with cold storage (CS) for prolonged heart preservation especially beneficial for high-risk recipients bridged to transplantation with Mechanical Circulatory Support (MCS). Methods: Between 2012 and 2018, we performed a retrospective single-center review of prospectively collected data. All patients who underwent heart transplantation with MCS using the OCS Heart (n=25) versus standard cold storage were included in this study. Results: During this period, 300 patients were implanted with left ventricular assisted device (LVAD) and 35 (11.6 %) were bridged to heart transplantation. There was no significant difference in donor and recipient characteristics and risk factors. The Index for Mortality Prediction after Cardiac Transplantation (IMPACT) score was a trend towards higher estimated risk of death at 1y in the OCS group (14.2 vs. 10.8% p= 0.083). Mean total ischemic time during preservation was statistically significantly longer in CS vs OCS group (210 (23) Vs 74.6 (13) min p=0.001). Median ex vivo normothermic heart perfusion time in OCS was 348.4(132; 955) min. There was significant difference in total out of body time between OCS group 423(67) Vs CS group 210(23) min p=0.002). The allografts were reperfused for 73 (33) vs 121 (45) minutes (p=0.01) before disconnection from cardiopulmonary bypass in OCS vs CS group. All patients were alive on the 30th days post implant in CS groups and 96% in OCS group (p=0.5). Conclusion: Normothermic ex-vivo preservation of the allograft during transportation with the organ care system might be beneficial for long-time out of body organ preservation in comparison of cold storage especially for recipients on mechanical circulatory support.
The Change of Urea to Creatinine Ratio is Associated With Postoperative Complications and Skeletal Muscle Wasting in Pancreatic Cancer Patients Underwent Pancreatoduodenectomy
Authors: Duan Kaipeng , Gong Mengting , Gao Xin , Wei Luxin , Zhu Dongming , Zhou Jin 
Published: August 2020

Abstract
BackgroundSurgical Patients with depleted skeletal muscle mass tend to have a worse outcome in the perioperative period, but the muscle mass is difficult to quantify. Here, we aimed to evaluate the relationship of perioperative change of serum urea to creatinine ratio (CUCR) with postoperative complication and skeletal muscle mass in pancreatic cancer patients underwent pancreatoduodenectomy (PD).MethodsPancreatic cancer patients underwent PD were included retrospectively. We analyzed the association of serum urea, creatinine, and urea to creatinine ratio (UCR) between patients with and without major postoperative complications. In a subset of patients with serial CT scans, we tested the correlation of the CUCR and the changes of CT-derived skeletal muscle area (SMA). Furthermore, the capacity of complication prediction of CUCR and CT-derived parameter were compared in these patients.ResultsWe included 321 surgical patients from January 2014 to July 2020. Patients were grouped with high- and low CUCR according ROC curve (cut-off: 71.3 for male and 67.4 for female). Patients with high CUCR (n=175) have higher complication rate (30.3% vs. 21.1%, p=0.002), including POPF (23.4% vs. 15.1%, p=0.017), infection rate (16.0% vs. 11.0%, p=0.043) and longer postoperative days to discharge (16.7±6.5, vs. 12.1±4.2, p=0.031). Multivariable logistic regression demonstrated CUCR was an independent predictor for complications in these patients, independent of age, sex and BMI. In a subset patients with serial CT scans, spearman correlation analysis shown both L3 muscle area and L4-psoas area were significantly correlated with CUCR (R2 = 0.64, p < 0.05; R2 = 0.62, p < 0.05, respectively). ConclusionPerioperative CUCR is an independent predictor for postoperative complications in pancreatic cancer patients underwent PD procedure. Elevated CUCR is a reflection of skeletal muscle wasting in postoperative surgical patients.
Prognostic Factors in the Pulmonary Metastasectomy and Efficacy of the Repeat Pulmonary Metastasectomy from Colorectal Cancer
Authors: Fukada Masahiro , Matsuhashi Nobuhisa , Takahashi Takao , Tanaka Yoshihiro , Okumura Naoki , Yamamoto Hirotaka , Shirahashi Koyo , Iwata Hisashi , Doi Kiyoshi , Yoshida Kazuhiro 
Published: August 2020

Abstract
Background Pulmonary metastasectomy from colorectal cancer (CRC) has improved with recent advances in chemotherapy, diagnostic techniques, and surgical procedures. The purpose of this study was to investigate the prognostic factors of response to pulmonary metastasectomy and the efficacy of repeat pulmonary metastasectomy.Methods This study was a retrospective, single-institution study of 126 CRC patients who underwent pulmonary metastasectomy between 2000 and 2019 at the Gifu University Hospital. Among these 126 patients, 47 cases (37.3%) had pulmonary re-recurrence after initial pulmonary metastasectomy, and 26 cases (20.6%) underwent the second pulmonary metastasectomy. ResultsThe 3- and 5- year survival rates of all 126 patients who underwent complete pulmonary metastasectomy were 84.9% and 60.8%, respectively. Univariate analysis in survival identified seven significant factors: 1) gender (p = 0.04), 2) past history of extra thoracic metastasis (p = 0.04), 3) maximum tumor size (p = 0.002), 4) hilar or mediastinal lymph node metastasis (p = 0.02), 5) preoperative carcinoembryonic antigen (CEA) level (p = 0.01), 6) preoperative carbohydrate antigen 19-9 (CA19-9) level (p = 0.03), and 7) repeat pulmonary metastasectomy for pulmonary re-recurrence (p < 0.001). On the multivariate analysis, only hilar or mediastinal lymph node metastasis (p = 0.02, risk ratio: 8.206, 95% confidence interval (CI): 1.566-34.962) and repeat pulmonary metastasectomy for pulmonary re-recurrence (p < 0.001, risk ratio: 0.054, 95% CI: 0.010-0.202) were significant. Furthermore, there was no significant difference in clinical and surgical characteristics between the initial and the second pulmonary metastasectomy except for intraoperative blood loss [10 (range 0-1130) mL vs 20 (range 0-220) mL, p = 0.008]. Conclusions Repeat pulmonary metastasectomy is likely to be safe and effective for re-recurrent cases that meet the indication. However, hilar or mediastinal lymph node metastasis was a significant independent prognostic factor of worse overall survival.
Thermoelastic Closed-Form Solutions of FGM Plates Subjected to Temperature Change in Axial and Thickness Directions
Authors: Chung Yen-Ling 
Published: August 2020

Abstract
An analytical solution of simply supported FGM plates under thermal loads is developed based on medium-thick plate assumption. Further to assume constant Poisson’s ratio and thermal expansion coefficient, the closed-form solutions of the FGM plates with through-the-thickness Young’s modulus under temperature change in x - and z -directions are evaluated, expressed in terms of the thermal axial force and thermal bending moment. The closed-form solutions confirmed by finite element analysis give a complete insight into the thermal-mechanical behavior of FGM plates. Hence, the deflection, strain, stress, axial force, and bending moment of the FGM plate under thermal loads in axial and thickness directions are discussed. Results show that the use of FGM makes the maximum stress from the top or bottom surface move to the inner portion of the FGM plate, and significantly reduces the maximum stress of the plates. Moreover, although the FGM plate is subjected to thermal load in the thickness direction, the deflection of the FGM plate can be zero by properly choosing the steep material gradation, directly derived from the obtained closed-form solution.
The complicated relationship between parental status and disability: A register study of the 1968 to 1970 birth cohorts
Authors: Namatovu Fredinah , Lundevaller Erling Häggström , Vikström Lotta 
Published: August 2020

Abstract
Background Having children is a major life course, yet some disabilities could make it biologically impossible and some others could limit access to necessary socioeconomic resources. To date, there is relatively little data on disability and parental status. Thus, our study investigates the relationship between disability and parental status.Methods This longitudinal cohort study uses register data from all people born in Sweden from 1968 to 1970 (n=440,202). Of these, 146,946 people were excluded as they did not meet the inclusion criteria. Therefore, the analysis was based on 293,256 people whom we followed from birth through the end of the study in 2010. We performed descriptive statistical analyses, graphical plots and logistic regression analyses to investigate the interplay between the use of disability benefits and the chance of having a first child. Additionally, we used contingency tables and multinomial logistic regression to investigate the chances of having a first child at different age intervals based on the age of starting on disability benefits.Results Receiving disability benefits was strongly associated with reduced chances of having children. Starting on disability benefits at a very early age was associated with low chances of having children during the individual’s lifetime. People that had a first child between 13─20 years of age were more likely to receive disability benefits during their 30s and 40s compared to the rest of the population. Men with disabilities were less likely to have children when compared to women with disabilities and to men and women without disabilities. Conclusions We found evidence of a complicated association between disability and parental status. Early recipients of disability benefits had reduced chances of having children, while having children at an early age was linked to increased risk of using disability benefits later in life. Our findings support policies for promotion of quality health to reduce early use of disability benefits and the related consequences. We further highlight a need to strengthen public health policies geared at reducing very early parenthood and support for young parents, this would promote individual health and could contribute to a reduction in early exits from work.
Biotechnological Improvement of Nutritional Value of Rice straw using Fungi
Authors: Salem Mohamed F. , gaafar khalid mahmoud mohamed , elkhair Reham Nabil Abo , Abonama Osama M. , Yasseen Asmaa Abd-Elrasol , Abouelkhair Ahmed Adel 
Published: August 2020

Abstract
BackgroundElimination of most of Egyptian environmental pollution depends on prevention of burning of agricultural wastes specially rice straw. Microbial improvement of nutritive value for rice straw is not only aids in the prevention of Egyptian environmental pollution but also solve the problem of shortage in animal feeds ingredients. The current study was designed to investigate the microbial improvement of rice straw via solid state fermentation using five strains of fungi namely Trichoderma viride, Trichoderma reesei, pleurotus ostreatus, Aspergillus oryzae and Aspergillus Fetidus. ResultsThis fermentation results in improving of nutritive value of rice straw by increasing its dry matter, protein, fat, ash and energy content with decreasing of fiber and organic matter content. These effects were variable according the type of fungi, which were very high for rice straw treated with Trichoderma viride and Trichoderma reesei followed by that treated by pleurotus ostreatus then those treated by Aspergillus oryzae and Aspergillus Fetidus.ConclusionIt could be concluded that the microbial treatment is a good way to improve the nutritional value of rice strawTrial registrationProject Nr.9/2017- Faculty of Veterinary Medicine- University of Sadat City. http://usc.edu.eg/ar/news/13741.aspx
WITHDRAWN: A global carbon and nitrogen isotope perspective on modern and ancient human diet
Authors: Bird Michael I , Crabtree Stefani , Haig Jordahna , Ulm Sean , Wurster Christopher 
Published: August 2020

Abstract
Stable carbon and nitrogen isotope analyses are widely used to infer diet and mobility in ancient and modern human populations, potentially providing a means to situate humans in global food webs. We collated 13,533 globally distributed analyses of ancient and modern human collagen and keratin samples. We converted all data to a common ‘Modern Diet Equivalent’ reference frame to enable direct comparison between ancient and modern human diets and the natural environment. This approach reveals a broad diet in ancient times, consistent with the human ability to consume opportunistically as extreme omnivores within complex natural food webs and across multiple trophic levels in every terrestrial and many marine ecosystems on the planet. In stark contrast, dietary breadth across modern non-subsistence populations has dramatically compressed by two-thirds, largely as a result of the rise of industrial agriculture and animal husbandry practices, as well as the globalization of food distribution networks.
Qigong Mind-Body Program for Caregivers of Cancer Patients: Design of a Pilot Three-Arm Randomized Clinical Trial
Authors: Budhrani-Shani Pinky , Raeesi Kristin , Walter Eli , Lewis Kai , Wang Wanyi , Cohen Lorenzo , Yeh Gloria Y , Lengacher Cecile A. , Wayne Peter M. 
Published: August 2020

Abstract
Background: Informal caregivers, often family and friends, experience significant psychological and physical distress leading to reductions in health and quality of life (QOL). Mind-body interventions focused on caregivers are often limited and do not address multiple barriers, including caregivers’ economic, geographic, and time constraints. Translation of in-person, community-based interventions to internet-based delivery may offer greater accessibility for caregivers, leading to increased adherence.Methods: Caring for Caregivers with Mind-Body Exercise implements a three-arm, pilot, randomized controlled trial to evaluate the feasibility of delivering a Qigong intervention (Eight Brocades) to cancer caregivers. A total of 54 cancer caregivers will be randomized into one of three 12-week programs: (1) community-based Qigong; (2) internet-based Qigong; or (3) a self-care control group. Study specific aims include 1) Modify intervention content for online delivery; 2) Evaluate the feasibility of recruiting and retaining cancer caregivers into a 12-week clinical trial; and 3) Evaluate the feasibility of collecting and managing data, and the suitability of questionnaires for this population. Several outcomes will be assessed, including caregiver QOL, caregiver burden, caregiver distress, perceived social support, physical function, and cognitive function. A 6-month follow-up will also assess longer-term changes in QOL and psychosocial wellbeing.Discussion: Findings will be used to inform the design and conduct of a large-scale comparative effectiveness trial evaluating caregivers who received Qigong training delivered through community-based vs internet-based programs. A finding that either or both programs are effective would inform care and options for caregivers.Trial registration: NCT04019301; registered on July 15, 2019; clinicaltrials.gov.
Interleukin-7 loaded oncolytic adenovirus improves CAR-T cell therapy for glioblastoma
Authors: Huang Jianhan , Zheng Meijun , Zhang Zongliang , Tang Xin , Chen Yaxing , Tong Aiping , Zhou Liangxue 
Published: August 2020

Abstract
Background: T cell with chimeric antigen receptors (CAR-T) has presented remarkable efficacy for blood cancer as an emerging immunotherapy. However, for solid tumors, the therapeutic efficacy is much impaired due to the lack of infiltration and persistence of CAR-T in tumor tissue. Thus, we constructed an interleukin-7-loaded oncolytic adenovirus and combined the use of oncolytic virus and CAR-T to improve the therapeutic outcome.Methods: We constructed an interleukin-7 loaded oncolytic adenovirus (oAD-IL7) and a B7H3-targeted CAR-T, and explored the efficacy of the single use of oAD-IL7, B7H3-CART or the combined therapy for glioblastoma in vitro and in vivo. The improved CAR-T anti-tumor efficacy was evaluated according to the proliferation, survival, persistence, exhaustion of T cells, and tumor regression.Results: Constructed oAD-IL7 and B7H3-CART presented moderate cytotoxicity during in vitro study, but failed to induce a thorough and persistent anti-tumor therapeutic efficacy in vivo. The combination of oAD-IL7 and B7H3-CART in vitro resulted in enhanced T cell proliferation and reduced T cell apoptosis. The joint efficacy was further confirmed using tumor-bearing xenograft mice. During in vivo study, the mice treated with both oAD-IL7 and B7H3-CART showed prolonged survival and reduced tumor burden. According to the ex vivo study, oAD-IL7 improved the proliferation and persistence of tumor-infiltrating B7H3-CART, but failed to reverse the exhaustion.Conclusions: Our results indicated that oAD-IL7 is a promising auxiliary therapy to improve the therapeutic efficacy of B7H3-CART in glioblastoma by providing the activating signals for tumor-infiltrating T cells. Our results also lay the basis for the future clinical trials for the combination of IL7-loaded oncolytic adenovirus and CAR-T therapy for glioblastoma.
LRRC3B polymorphisms contributed to breast cancer susceptibility in Chinese Han Population
Authors: Jin Tianbo , Peng Linna , Xing Shishi , Li Dandan , He Chunjuan , He Xue , Wang Li 
Published: August 2020

Abstract
Purpose

LRRC3B gene, as a tumor suppressor gene was involved in the development and progress of breast cancer (BC). However, the effect of LRRC3B polymorphisms on BC has rarely been reported. In the study, we aims to evaluate the relation between LRRC3B variants and BC risk.
Methods

Among 563 BC patients and 552 healthy controls, ten single-nucleotide polymorphisms (SNPs) in LRRC3B were genotyped by Agena MassARRAY. Odds ratios (OR) and 95% confidence interval (CI) was calculate using logistic regression model.
Results

Our study demonstrated that rs1907168 polymorphism (OR = 0.71, p = 0.017) reduced the risk of BC in the overall. In stratified analyses by age, rs1907168 decreased (OR = 0.53, p = 0.002) while rs78205284 (OR = 2.83, p = 0.034) increased BC susceptibility among the population at age ≤ 51 years. Clinical parameters such as tumor size, the status of PR and Ki67 were associated with LRRC3B variants. Furthermore, we found that the association of ‘GATT’ haplotype with an increased risk for BC. In addition, LRRC3B gene was down-regulated in BC tumor and had a poor prognosis in BC in silico analysis.
Conclusion

Our study firstly found LRRC3B SNPs contributed to the risk of BC, suggesting LRRC3B variants might help to predict BC progression.