bluuebunny/crossref_metadata_2025_split huggingface dataset:
A PROSPECTIVE STUDY ON TRANSVAGINAL DOPPLER SONOGRAPHY OF ENDOMETRIUM IN WOMEN WITH POSTMENOPAUSAL BLEEDING.
Authors: Choudhary Dr. Richa , Sinha Dr. Rishikant 
Published: March 2020

Objectives: This present study was to evaluate the clinical profile and Transvaginal Doppler Sonography findings of endomterium in women with postmenopausal bleeding.
Methods: Detail history, clinical examinations and relevant investigations were performed to all cases of PMB. BMI was calculated. Transvaginal sonography of the uterus and Doppler analysis of the blood flow were performed using vaginal probe at 5-7.5 megahertz. Endometrial thicknesses as well as other pathologies in the cavity were noted. Resistive index was calculated.
Results: Data was analyzed by using SPSS version 26 software. One sample statistical methods was used. Mean ± standard deviation was observed. P-value was taken equal to less than 0.05 for significant differences.
Conclusions: Highest prevalence of PMB was seen in women with age greater than 50 years. Most of the cases had BMI 20-25 kg/m2. Most of the benign and malignant cases had parity status P3-P4 and P1-P2 respectively. Endometrial thickness of malignant PMB cases was significantly greater than benign PMB cases. Resistive index of malignant PMB women was significantly lower than benign PMB women. Hence, promotion of healthy lifestyles and contraceptives in early reproductive life and awareness for the need of early screening should be recommended to reduce the prevalence of PMB. And early diagnosis and management of post menopausal bleeding are needed for prevention from malignancy.
Key words: Postmenopausal Bleeding, Benign, Malignancy, Transvaginal Doppler Sonography.
THE STUDY OF DETECTION OF DENGUE CASES BY NS1 ANTIGEN AND IGM ANTIBODY IN RIMS, ADILABAD, INDIA.
Authors: Zade Dr. Tanajee , Srinivas Dr. K. , Berad Dr. Akshay 
Published: March 2020

Dengue fever is an acute febrile arboviral disease affecting tropical & subtropical regions of the world. Dengue infection produces a spectrum of clinical illness, ranging from an asymptomatic to its most severe form like dengue haemorrhagic fever and dengue shock syndrome. In view of high morbidity and mortality, it is imperative to have a rapid and sensitive laboratory assay for early detection of the dengue infection. The newer parameter NS1 antigen has gained a lot of interest for early diagnosis of the disease. Detection of non-structural antigen (NS1 Ag), IgM and IgG antibody may help in the early diagnosis. The present study was conducted in a RIMS Adilabad, tertiary care hospital & medical college in the Department of General Medicine. A total of 100 serum samples were processed from suspected cases of dengue fever by using dengue test for detection of NS1 antigen and IgG antibodies. Platelet counts of all these cases were noted. . Of these 100 subjects 85 were serologically proved to have dengue illness, 57 patients were NS1 antigen positive, 28 patients were IgM antibody positive patients. As the NS1 antigen is detectable in blood from day one after onset of fever, its assay is an effective tool for early diagnosis of dengue infection so as to avoid complications.
Key words: Dengue, NS1 Antigen, IgM antibody, Platelet
EFFECTIVENESS OF NON-SURGICAL PERIODONTAL THERAPY ON AMLODIPINE INDUCED GINGIVAL ENLARGEMENT: A CASE REPORT
Authors: Mona Dagar , Prerna Kataria 
Published: March 2020

Gingival enlargement, [sometimes abbreviated to GO (gingival overgrowth)] is an increase in the size of the gingiva. It is a common feature of gingival disease. Gingival enlargement is a well known side-effect of drugs like anticonvulsants, calcium channel blockers and immunosuppressant. A case of amlodipine induced gingival enlargement was reported and after drug substitution when the patient was treated non-surgically (scaling and root planing), the enlargement subsides to a normal state which suggested the effectiveness of non-surgical periodontal therapy in the treatment of drug induced gingival enlargement.
Keywords: Anticonvulsants, Immunosuppressants, Calcium channel blockers, gingival enlargement
TO FIND OUT THE TOXICITY PROFILE OF TWICE WEEKLY CISPLATIN OVER CONVENTIONAL ONCE WEEKLY CISPLATIN BASED CRT IN LOCALLY ADVANCED CERVICAL CANCER.
Authors: Vardhan Ranveer , Rana Amit , Gupta Manoj , Seam Rajeev , Gupta Manish 
Published: March 2020

Background: Carcinoma cervix ranks fourth most common malignancy (for both incidence & mortality) globally and third most common diagnosed malignancy in females (~16.5%) in India, (after breast & lip/oral cavity), with about 80% of the total burden occurring in developing countries like India.
Methods: This Prospective comparative study was conducted in the Department of Radiotherapy and Oncology TCC, IGMC, Shimla, in patients suffering from
advanced carcinoma of cervix.
Results: Hematological toxicities were seen mainly in the study group as compared to the control group (28 patients in the study group vs. 22 patients in control group). The difference was not statistically significant (p = 0.214). Grade III toxicities were seen in 5 patients in study group and 4 patients in control group. Cutaneous toxicity of different grades was seen in all the patients in the study arm and of the patients in the control arm. There was no statistically significant difference between the two arms (p=0.8121).
Conclusion: Both (Study & control) groups are comparable in terms of toxicity and are equally well tolerated by the patients.
Keywords: Chemoradiotherapy, RT, Partial response, toxicity.
TO COMPARE THE TOXICITY PROFILE OF ACCELERATED RADIOTHERAPY (SIX FRACTIONS PER WEEK) WITH CONCOMITANT CHEMO-RADIOTHERAPY IN LOCALLY ADVANCED HEAD AND NECK CANCER
Authors: Kaushal Vikrant , Rana Amit , Gupta Manoj , Seam Rajeev , Gupta Manish 
Published: March 2020

Background: Head and neck malignancies are common among males in India. The age adjusted incidence rate of head and neck cancer in India in males is 16.4/100,000 and in females it is 8.8/100,000.In All India Institute of Medical Science head and neck cancer represents 25% of all malignancies registered
Methods: This prospective randomized study was conducted in the Department of Radiation Therapy & Oncology, Regional Cancer Centre, IGMC, Shimla and patients were enrolled for a period of one year, from July 2012 to July 2013.It included all the eligible, previously untreated patients of squamous cell carcinoma of Head and Neck with histologically confirmed diagnosis and no evidence of distant metastasis. The sites included were oro-pharynx, hypo-pharynx and larynx with stages III, IV A and IV B.
Results: Grade 3 and grade 4 skin toxicities were higher in CRT arm but without statistically significant difference from that in ART arm. G3 & G4 mucositis was higher in the Concomitant CRT arm however the difference was not statistically significant. G2 and G3 Laryngeal Toxicities were higher in Concomitant CRT arm as compared to Accelerated arm but the difference was not statistically significant. G2 & G3 haematological toxicities were significantly (combined p value = 0.002) higher in the concomitant CRT arm (32.4%) as compared to Accelerated RT arm (2.9%). Only one patient in accelerated arm had any hematological toxicity.
Conclusion: Higher peak incidence of toxicities was seen in concomitant CRT arm as compared to accelerated arm.
Keywords: Toxocity, six fraction, chemoradiation, Local control
PREVALENCE OF HYPERTENSION AMONG PRE-ELDERLY PATIENTS ATTENDING PERIPHERAL HEALTH CENTRE OF TERTIARY CARE HOSPITAL OF INDIA
Authors: Sharma Dr. Munish Kumar , Gour Dr. Neeraj , Goel Dr N K , Sharma Dr. Deepak , Chaudhary Dr. Meenakshi , Chouksey Dr. Megha 
Published: March 2020

Background: In this modern era, chronic noncommunicable diseases (NCDs) are a major global health challenge with numerous grave complications on the human body. Hypertension is the most common disorder which is being encountered in the outdoor patients
Method: This cross sectional study was undertaken to provide the data on the prevalence of hypertension amongst patients who were aged 20 years and above (pre elderly) and who attended the Out Patients Department of the Rural Health & Training Centre of tertiary care hospital of Chandigarh city of India.
Results: Association of age with systolic blood pressure & diastolic pressure was found to be highly significant (P < 0.001). On the other hand association gender with systolic blood pressure & diastolic blood pressure was also found to be highly significant (P < 0.001). Logistic regression was also applied & it was found that age and male gender is a better predictor of diastolic hypertension but it was found to be non-significant (P > 0.05).
Conclusion: Hypertension was found to be highly prevalent among the outdoor patients of Rural Health & Training Centre of Chandigarh, India. This study warrants the need of an early detection of hypertension, which can be accomplished by a periodic screening of the people.
Key words: Hypertension; India.
DILEMMA OF THYROID NODULES AND THE TIME TESTED RATIFICATION OF USG WITH HISTOPATHOLOGY, IN A SHORT PROSPECTIVE STUDY OF THE LOCAL POPULATION.
Authors: Lodha Dr. Sambhav , Soni Dr. Viral , Mor Dr. Vandita , Kapadia Dr. Mahin , Pooja Dr. 
Published: March 2020

Ultrasonography enjoys the intrinsic advantages of universal availability economy and non-invasive nature. It presents no radiation hazards and can be readily repeated. Ultrasonography can demonstrate normal thyroid anatomy and pathologic with remarkable clarity. The role of ultrasonography as an initial diagnostic modality for thyroid noduleswith high sensitivity and specificity as correlated with the pathological findings.
Keywords: Thyroid nodules, Ultrasonography.
ROLE OF VITAMIN B12 SUPPLEMENTATION IN METFORMIN INDUCED DIABETIC NEUROPATHY IN INDIAN PATIENTS. CAN SUPPLEMENTATION HELP?
Authors: Merchant Dr. Fatema. S. , Merchant Dr. Arwa. S. 
Published: March 2020

Metformin is one of the most commonly used oral hypoglycemic drug amongst type II diabetes mellitus patients, particularly overweight with normal kidney functions. Literature reports an average of 10-30% of patients taking metformin for longer duration (more than 4 years) have shown some signs of vitamin B12 deficiency.
Thus the present study was planned to assess the development of peripheral neuropathy in metformin users due to Vitamin B12 deficiency and effect of its supplementation was assessed for improvement in terms of VPT (Vibration perception threshold) score assessed by Biothesiometer which is a simple, portable, reliable, non-invasive method to screen the peripheral neuropath
Unique about this study is, evaluating the effect of B12 supplementation on Indians patients. They being primarily vegetarian are at more risk to develop Vitamin B12 deficiency, so, metformin induced Cobalamin deficiency assumes greater risk in such patients in terms of development and progression of peripheral neuropathy.
STUDY OF CENTRAL STORE DEPARTMENT ACTIVITIES BY PROCESS FLOW MAPPING IN A TERTIARY CARE HOSPITAL
Authors: Bhatia Pallavi , Bhatia Kapil , Damania Binal , Patil Neelam 
Published: March 2020

Introduction: Healthcare industry is witnessing sharp rise in price in almost all its products and services. Hospital’s inventory management has become increasingly important in the recent past. Organizations process mapping is composed of activities involved in defining what an organizational entity does, who is responsible, to what standard organization process should be completed, and how the success of an organizations process can be determined.
Aim and objectives: This study focuses on basic components of supply chain process in the central store to make it more efficient in sales, distribution and storage of drugs.
Materials and methods: Data was collected from central stores department for two months through process mapping; Quantitative and observational/ prospective design are used to identify the main supply issues and data analysis.
Results: The compliance was found to be 100 % in all the different processes like procurement process, internal quality checks, storage of drugs, ledger maintenance & documentation and maintenance of special drugs except GRN date which was 75.45%, storage of high risk medicine amounting to 81.82%.
Conclusion: Innovative design of supply chain has a significant impact on selection of and cooperation with excellent suppliers, improves supply chain efficiency, and encouragement of QM practices.
Keywords: Inventory management, Supply chain, Central stores department, Drugs
TO FIND OUT THE VARIATION OF SYMPATHETIC & PARASYMPATHETIC TESTS BETWEEN MALE & MENSTRUAL PHASE OF MENSTRUAL CYCLE IN FEMALE.
Authors: Solanki Dr. Hitesh Kumar , Yadav Dr. Omnath P , Gojiya Dr. Anita J 
Published: March 2020

The hormonal fluctuations that occur during normal menstrual cycle has profound influence on autonomic functions. This influence on autonomic nervous system may affect cardiovagal control. The aim of the study is to find out the variation of Parasympathetic function tests during different phases of menstrual cycle in young healthy females.
The mean E:I ratio in Menstrual Phase of menstrual cycle in females is 1.34 ± 0.06.
The mean E:I ratio in males is 1.41 ± 0.12.
The mean Postural SBP in Menstrual Phase of menstrual cycle in females is 97.76 ± 5.13 mmHg. The mean Postural SBP in males is 103.24 ± 6.88 mmHg.
The study concludes that there was statistically significant heart rate variability during three phases of the menstrual cycle, as observed by the increased sympathetic discharge in the luteal phase compared to the increased parasympathetic discharge in the follicular phase. The results of our study have emphasized the complexity of the relationship between ovarian steroids and various hemodynamic regulatory systems.
Keywords: Sympathetic, Parasympathetic & Menstrual.
TO STUDY THE CORRELATION BETWEEN SONOGRAPHIC MODIFICATION OF CORMACK LEHANE SCORING WITH ACTUAL CL GRADING DURING DIRECT LARYNGOSCOPY
Authors: Koundal Dr. Vishal 
Published: March 2020

Background: Airway assessment is an essential aspect of preanaesthetic assessment. Presently, prediction of difficult airway is based on clinical assessment of airway.
Methods: Prospective Observational conducted at Department of Anesthesiology, Dr. RPGMC Kangra at Tanda, Himachal Pradesh.
Results: It was observed that 44% patients (n=88) were in grade 2 followed by 27 % (n=54) in grade 1, grade 3 was observed in 24.5% patients (n=49) whereas Cormack Lehane grade 4 was seen in 4.5% patients (n=9)
Conclusion: The thyromental distance was more than 6.5 cm in the majority of patients (87.5%) while 12.5% had a thyromental distance less than 6.5 cm. There was a significant difference in Thyromental distance between different Cormack Lehane grades (P=0.001)
Keywords: Ultrasound, endotracheal intubation, direct laryngoscopy
A STUDY ON THE CORRELATION OF ADENOSINE DEAMINASE AND GLYCATED HAEMOGLOBIN IN THE PATIENTS OF TYPE 2 DIABETES MELLITUS.
Authors: Singh Supriya , Suri Arpita , Sinha Maheep , Fiza Bushra 
Published: March 2020

Background & Objectives: Adenosine modulates insulin action on various tissues and its concentration in tissues is affected by Adenosine Deaminase (ADA) levels. ADA is an enzyme involved in purine metabolism and is considered to be a marker of T cell activation. Immunological disturbances in type 2 diabetic individuals have an association with cell mediated responses and inappropriate T-lymphocyte function. Hence, the study was undertaken to determine the levels of Serum ADA activity in patients of type 2 DM and its correlation with parameters of glycemic profile such as Fasting blood sugar (FBS) and Glycated Haemoglobin.
Material and Methods- A total of 100 patients diagnosed for type 2 DM visiting the Outpatient Department of General Medicine and Endocrinology at Mahatma Gandhi Medical College & Hospital, Jaipur were enrolled for the study based on predefined inclusion and exclusion criteria. Blood samples were collected for all enrolled patients and analysed for the investigations like Serum BSF, HbA1c and Serum ADA.
Results- In the study, BSF, mean HbA1c and serum ADA level was significantly higher in diabetic group in comparison to control group (p=0.000). The diabetic group was subdivided on the basis of HbA1c levels, HbA1c ≤ 8% as good glycemic control and HbA1c > 8% as poor glycemic control. BSF, mean HbA1c and serum ADA levels were observed to be significantly higher in poor glycemic control group as compared to that of good glycemic control. A significant positive correlation between S. ADA and HbA1c activity was also seen (r= 0.388).
Conclusion- Increased ADA level can be used to determine the glycemic status in the patients of type 2 DM and serve as a marker for insulin resistance. Hence, by analysing ADA levels in diabetes, glycemic control and insulin resistance can be assessed. Raised ADA levels can be an early indicator of progressive diabetic change and help to take preventive measures for the development of diabetic complication and thereby improving the outcome of the disease.
Keywords- Diabetes Mellitus, Adenosine Deaminase, Glycated haemoglobin
STANDARDIZATION OF HYDROPONIC AND WILD GROWING TEUCRIUM POLIUM L. BY HPLC
Authors: M Galstyan H. , H Dumanyan K. , O Tsaturyan A. , H Gukasyan N. , A Engibaryan A. , B Chichoyan N. 
Published: March 2020

It was approved that flavonoids (luteoline, apigenin) and phenylpropanoid glycosides verbascoside best separation was implemented by using UM detector and isocratic isolation regime.
Depending on the growing conditions main influencing substance quantities fluctuate: in the wild growing plants were synthesized nearly 2 times more than in hydroponic growing plants. For the study were obtained 500 alcoholic extracts from hydroponic and wild growing T. polium. The studied samples before analysis were developed three-chloral-acetic-acid anhydride and centrifuged by 10 minutes 12000 rev/m speeds. The solution volume of each injected analysis was 10 mkl. Then some amount of standard verbascoside, luteolin and apigenin samples were solved in 1ml ethyl alcohol and were filled into the special test tubes for analysis. By T. polium chloroform-methanol and tower chromatography water fractions teupolizoid, verbascoside and poliumozid phenylpropanoid glycosides were separated which Rf were equal to 0.25, 0.5, 0.37 in our researches in the past. These compounds composition was proved by complex spectroscopic methods. They had close structure to each other and verbascoside enclosed peaks in HPLC were supposed that belong to poliumozid and teupoliozid and also was brought the above mentioned compounds quantities by calculating chromatography data.
Keywords: Teucrium polium L., wild and hydroponic, HPLC, standardization, verbascoside, apigenine, luteolin.
NANO-ENGINEERED IRRIGATING SOLUTIONS AND LASERS – AN ANTIBACTERIAL STUDY AGAINST ENTEROCOCCUS FAECALIS
Authors: Sundaresan Balagopal , James Vandana , Sebatni Anisha , M Nazrin , Hemasathya Bahavathi Ananthan , Chandrasekaran Charanya , Senthilnathan Natarajan 
Published: March 2020

BACKGROUND:
Enterococcus faecalis (E. faecalis) is the most commonly detected micro-organism in asymptomatic and persistent endodontic infections. Thorough disinfection of the root canal is more important than proper shaping for a successful endodontic treatment. This study is an attempt to implement nanoparticles which have proven anti-bacterial efficacy as irrigating solutions against E. faecalis.
AIM:
To compare and evaluate the anti-bacterial efficacy of 5% sodium hypochlorite (NaOCl), 0.2% chitosan nanoparticles solution (ChNP) and 0.01% silver nanoparticles solution (AgNP) against E.faecalis with and without diode laser activation.
MATERIALS AND METHODS:
70 single rooted mandibular premolars were included in this study. Access opening, working length determination and biomechanical preparation were standardized. Samples were embedded in putty material inside an eppendorf tube to simulate periodontal ligament and autoclaved followed by inoculation of E.faecalis (MTCC 439) and incubated at 37℃ for 7 days. The samples were divided into 7 groups (10 samples in each group). Group 1- No treatment (Negative control), group 2 - 5% NaOCl without activation (Positive control), group 3 - 5% NaOCl with diode laser activation, group 4- 0.01% AgNP without activation, group 5- 0.01% AgNP with diode laser activation, group 6- 0.2% ChNP without activation and group 7- 0.2% ChNP with diode laser activation. A final rinse of the respective irrigants and activation were performed, followed by counting the colony forming units. Statistical analysis used were one-way analysis of variance (ANOVA) followed by Tukey’s post-hoc tests. Results showed that diode laser in combination with 5% NaOCl and 0.2% ChNP had significant effects in the reduction of microbial colony counts of E. faecalis in comparison to other experimental groups.
Keywords: Nanoparticles, Irrigation, LASER, Enterococcus faecalis
LEMON SCORE: A TOOL TO PREDICT DIFFICULT AIRWAY IN ED IN INDIAN SETTING.
Authors: Tripathi Sumalya , Shinde Dr V.S , Shaikh Zahid Parvez 
Published: March 2020

Background: Airway management is a critical need in many acutely ill and injured patients. Inadequate delivery of oxygen to brain and other vital structures is the quickest killer. Emergency airway management is the major key for successful resuscitation in ED. Emergency medicine is an emerging branch in India at present and no research study has been conducted to evaluate difficult airway prediction score. Hence this study aimed to find the use of LEMON score as a tool to predict difficult airway in our ED.
Methods: All the patients requiring invasive mechanical ventilation with age >12 years, not admitted outside and admitted to the emergency medicine department from July 2017 to September 2019 were included in our study. A total of 67 patients required invasive ventilation and were assessed by LEMON score for difficult intubation. This score is related to number of attempts required and Cormack lehane class of laryngoscopic view while intubation.
Results: In the “LOOK EXTERNALLY” the most common finding was edentulous mouth with occurrence of 26.87%. In ‘EVALUATE’ component the most common difficulty was 2-3-2. In MALLAMPATI CLASS 56.71% were class I, 39.39% were class II. In OBSTRUCTION component of LEMON, 98.51% had no obstruction. In NECK MOBILITY component we found that 85.1% subjects had mobile neck and only 15.15% subjects had restricted neck mobility. We observed that the LEMON score is 60% sensitive and 96.15% specific to predict difficult airway. The positive predictive value was 83.33%.
Conclusion: This tool can reduce the chance of unexpectedly encountering difficult airway.