bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-cultural translation, adaptation and validation of a Japanese version of the Functional Index for Hand Osteoarthritis (J-FIHOA)
Authors: Nakagawa Yasunobu , Kurimoto Shigeru , Maheu Emmanuel , Matsui Yuichiro , Kanno Yuri , Menuki Kunitaka , Hayashi Masanori , Nemoto Tetsuya , Nishizuka Takanobu , Tatebe Masahiro , Yamamoto Michiro , Iwatsuki Katsuyuki , Dreiser Renée Liliane , Hirata Hitoshi 
Published: January 2020

Abstract
Background: Hand osteoarthritis (OA) has a wide spectrum of clinical presentations and physical function is one of the core domains where patients suffer. The Functional Index for Hand Osteoarthritis (FIHOA) is a leading assessment tool for hand dysfunction. Our objective was to make a Japanese version of FIHOA (J-FIHOA) and validate it among Japanese hand OA patients. Methods: Forward and backward translation processes were completed to create a culturally adapted J-FIHOA. A prospective, observational multicenter study was undertaken for the validation process. Seventeen collaborating hospitals recruited Japanese hand OA patients who met the American College of Rheumatology criteria. A medical record review and responses to the following patient-rated questionnaires were collected: J-FIHOA, Hand20, Health Assessment Questionnaire (HAQ), numerical rating scale for pain (NRS pain) and Short Form 36 Health Survey (SF-36). We explored the structure of J-FIHOA using factor analysis. Cronbach’s alpha coefficients and item-total correlations were calculated. Correlations between J-FIHOA and other questionnaires were evaluated for construct validity. Participants in clinically stable conditions repeated J-FIHOA at a one- to two-week interval to assess test-retest reliability. To evaluate responsiveness, symptomatic patients who started new pharmacological treatments had a 1-month follow-up visit and completed the questionnaires twice. Effect size (ES) and standardized response mean (SRM) were calculated with pre- and post-treatment data sets. We assessed responsiveness, comparing ES and SRM of J-FIHOA with other questionnaires (construct approach). Results: A total of 210 patients participated. J-FIHOA had unidimensional structure. Cronbach’s alphas (0.914 among females and 0.929 among males) and item-total correlations (range, 0.508 to 0.881) revealed high internal consistency. Hand20, which measures upper extremity disability, was strongly correlated with J-FIHOA (r=0.82) while the mental and role-social component of SF-36 showed no correlations (r=−0.24 and −0.26, respectively). Intraclass correlation coefficient for test-retest reliability was 0.83 and satisfactory. J-FIHOA showed the highest ES and SRM (−0.68 and −0.62, respectively) among all questionnaires, except for NRS pain. Conclusions: Our results showed J-FIHOA had good measurement properties to assess physical dysfunction in Japanese patients both for ambulatory follow-up in clinical practice, and clinical research and therapeutic trials.
NEAT1 attenuates osteoarthritis development by sponging miR-424-5p and up-regulating SMAD7 expression
Authors: Zhang Dezhi , Song Lin , Wang Xiaohe 
Published: January 2020

Abstract
Background: Osteoarthritis is extensively accepted as a chronic joint disease primarily characterized by destruction of articular cartilage, yet with rare molecular mechanism underlying its development and limited therapeutic targets in clinic. We here to investigate the role of NEAT1 and its molecular basis in OA development. Methods: Rat tissues and chondrocytes with osteoarthritis were used to detect the mRNA level of SMAD7 and miR-424-5p in which the correlation between them was also analyzed; Overexpression and knockdown of miRNA-424-5p were implemented to detect the regulation on SMAD7; The level of inflammatory factors and cell apoptosis of chondrocytes were detected with the opposite treatment on miR-424-5p; The potential interacting lncRNA was identified through online tool and RIP was employed to demonstrate the association between them; The biological coordination between NEAT1 and miR-425-5p in osteoarthritis was explored via the effects on inflammatory factors and cell apoptosis of chondrocytes. Results: Significantly, our results showed that levels of miR-424-5p are negatively correlated to expression of SMAD7 in rat cartilage tissues and chondrocytes, and overexpression of miR-424-5p was demonstrated to down-regulate SMAD7 expression. Additionally, the results also showed that miR-424-5p regulated expression of pro-inflammatory cytokines and apoptosis in chondrocytes via a SMAD7-dependent manner. Morever, the potential interacting lncRNA of miR-424-5p was figured out, and NEAT1 was proved to inversely mediate miR-424-5p expression leading to up-regulation of SMAD7. Further, NEAT1 was also estimated to work concert with miR-424-5p orchestrating expression of pro-inflammatory cytokines and chondrocytes apoptosis to ameliorate development of OA. Conclusions: We here demonstrate that NEAT1 could attenuate OA development via sponging miR-424-5p and thus up-regulating SMAD7 expression. Our data suggest that NEAT1-miR-424-5p-SMAD7 axis might be a potential therapeutic target for OA patients.
Tissue Adhesive for Wound Closure in Fast-recovery Total Hip Arthroplasty: A Prospective, Randomized and Controlled Study
Authors: Kong Xiangpeng , Yang Minzhi , Cao Zheng , Chen Jiying , Chai Wei , Wang Yan 
Published: January 2020

Abstract
Background We aimed to present our experience of adopting tissue adhesive as adjunct to standard wound closure in total hip arthroplasty (THA) and evaluate its role and cost performance. Methods From September 2019 to November 2019, we prospectively enrolled consecutive patients who underwent simultaneous bilateral THA in this randomized and controlled study. The allocation of tissue adhesive was randomized to either hip. The patients’ age, gender, body mass index (BMI), diagnosis, postoperative length of stay (LOS), dressing changes, wound evaluation scores, wound-related cost and complications were collected and analyzed. Results During the hospital stay, the dressing change in hips with tissue adhesive was significantly less than that in the other hips (p=0.000). However, the wound-related cost in hips with tissue adhesive was significantly higher (p=0.000). At one-month follow up, patient-reported wound measurement of hips with tissue adhesive was significantly more superior than the other hips (P=0.004). Seventeen patients preferred tissue adhesive and only five patients preferred the standard wound closure. Conclusions Tissue adhesive could significantly reduce wound drainage and increase patient satisfaction, which can be an ideal adjunct to standard wound closure in fast-recovery THA.
Measurement and Analysis of Sagittal Spinal Morphology and Function in Adolescents: A Cross-Sectional Study
Authors: Feng Qiang , Zhou Yu , Wang Fubaihui , Wang Minghao 
Published: January 2020

Abstract
Background: Spine health is a significant aspect of adolescent health, but few studies have focused on adolescent sagittal plane health. This study aimed to investigate the current status of sagittal spine morphology and function in adolescents. Method: This cross-sectional study analysed 1152 effective samples obtained from junior and senior high school students (543 boys and 609 girls) from demonstration, middle-level, and general schools in Beijing. Spinal sagittal morphology and function were measured by Spinal Mouse, a spine measuring instrument. The sacrum angle (SA), thoracic kyphosis angle (TKA), lumbar lordosis angle (LLA), inclination angle (INA), sacral range of motion (SROM), thoracic range of motion (TROM), lumbar range of motion (LROM), and inclination range of motion (IROM) were measured. The Matthiass test was used to measure the change in angle after external load placement on the adolescent spine. Sacral angle change (SAc), thoracic angle change (TKAc), lumbar lordosis angle change (LLAc), and inclination angle change (INAc) were also analysed. Result ： Abnormal TKA rate was 48.2% and 44.7% in the junior and senior high school. Abnormal LLA rate was 44.6% and 55.4%. In the spinal mobility test of the junior high school , SROM, TROM, LROM, and IROM were 60.6°±19.1°, 23.0°±16.6°, 23.0°±16.6°, and 136.1°±16.9°, respectively, for boys and 66.0°±34.4°, 14.0°±17.3°, 66.3°±18.6°, and 127.4°±26.8°, for girls. There were significant differences found between boys and girls (P<0.05 or P<0.01). In the Matthiass test, INAc of the junior high school was 5.7°±5.0° and 2.6°±3.7° for boys and girls, whereas INAc of the senior high school was 2.8°±3.3 and 1.6°±3.0, showing significant differences (P<0.01). The canonical correlation coefficient of SA, SROM, LROM, and IROM was 1.3877, -2.5384, -0.6625, and 1.6336. SROM and LROM were found to be negatively correlated with spinal function, whereas IROM was positively correlated with spinal function. Conclusion: Adolescents have a high incidence of thoracic kyphosis. During flexion and extension, the thoracic and lumbar vertebral activity and overall activity are better in boys. However, girls are better at maintaining the strength quality of stable muscle groups with a normal spine shape. Sacral obliquity and pelvic position greatly influence the spinal morphology of adolescents.
The influence of different hook tip depths on the treatment of acromioclavicular joint dislocation with clavicular hook plate – a retrospective study
Authors: xu ding , Luo Peng , Shi Yulong , Wang Weikang , Guo Weijun , Chen Jianming Chen 
Published: January 2020

Abstract
Background The purpose of this study was to research the effect of different hook depths on the efficacy and complications of AC dislocation treatment with hook plate, and to provide valuable reference for clinical treatment.Method We retrospectively analyzed the prospectively collected data from 305 consecutive patients with AC joint dislocation between April 2013 and May 2017 at our institute. We defined〝hook tip depth〞as the position of the hook tip relative to the acromion at the coronal plane. According to the division where the tip of the hook was located, the cases were divided into Group A, Group B, Group C, and D group. All patients were required to conform to regular follow up postoperatively. Dislocation and implant maintenance are assessed by routine shoulder imaging. Functional results were evaluated using Constant-Murley criteria.Results A total of 305 cases were included in follow-up and 27 cases were lost. We used Constant-Murley criteria to evaluate functional results. The score of Group B was significantly higher than group A and group C (P<0.01). For evaluation of acromioclavicular joint reduction, we used CCD in imaging to evaluate. There was significant difference between the three groups. Joint reduction was obtained in all patients. Postoperative infection and hardware failure did not present. There were no fractures of acromion and coracoids process. There were 83 cases of shoulder pain, 93 cases of SIS and 124 cases of subacromial erosion. The incidence of complications in group A was significantly higher than group B and group C.Conclusions The relative position of the hook tip and acromion can significantly affect the efficacy and complications of the clavicular hook plate in the treatment of acromioclavicular joint dislocation. During surgery, we should control the depth of hook tip and try our best to put the tip of the hook into the area of group B to achieve an ideal postoperative effect and avoid the occurrence of various complications.
Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast Cells
Authors: Hajimirzaei Nima , Khalili Nazila Pour , Boroumand Behshad , Safari Fatemeh , Pourhosseini Armin , Tavakoli Fatemeh 
Published: January 2020

Abstract
Background: Macrolides are a clinically well-established class of antibiotics. Macrolides induce cardiotoxicity by blocking ERG potassium channels in cardiac myocytes. The aim of this study was to compare the effects of erythromycin, clarithromycin and azithromycin on cell viability and expression of ERG1 gene in H9c2 cells. Methods: Cell viability and ERG1 gene expression of H9c2 cells in 3 different concentrations, 1, 10 and 25µg/ml, after 48 and 72 hours were determined by MTT test and Real time-PCR method respectively. Results: According to the results, these antibiotics decreased cell viability in a concentration and time-dependent manner. After 48 hours, the growth of H9c2 cells treated with erythromycin and clarithromycin (at 1 and 25 μg/ml) were inhibited significantly compared to control group (p <0.05). All three groups of antibiotics showed toxic effects on cells after 72 hours in all concentrations. Azithromycin-inhibiting effects were significantly higher than two other groups after 72 hours of treatment. The expression of ERG1 gene increased in all three groups of antibiotics by increasing the concentration and duration of treatment. Azithromycin had the most pronounced effect on ERG1 expression in 48 and 72 hours. Conclusions: This study indicated that these macrolides affect ERG1 expression due to their potential cardiac adverse effects. Further investigations are required to understand the exact mechanism of cardiotoxicity associated with macrolides.
Prevalence of potential drug- drug interactions and associated factors among outpatients and inpatients in Ethiopian Hospitals: a systematic review and Meta-analysis of observational studies
Authors: Ayenew Wondim , Asmamaw Getahun , Issa Arebu 
Published: January 2020

Abstract
Background A very few number of studies are available regarding the evaluation of potential drug- drug interactions in Sub-Saharan Africa. This is also a problem in Ethiopian health care system. Now a days, in Ethiopia polypharmacy is increased due to comorbid conditions in the hospital health care system, a large number of patients are treated in the outpatient setting and also hospitalized and there is a high possibility for drug- drug interactions. Therefore, this study aims to summarize the prevalence of potential drug- drug interactions and associated factors in hospitals, both among hospitalized patients and outpatients in Ethiopia.Method Literature search was performed through accessing legitimate databases in PubMed/MEDLINE, Google Scholar and Research Gate for English-language publications. Advanced search strategies were applied in Science Direct and HINARI to identify any additional papers and published reviews and to retrieve relevant findings closely related to prevalence of potential drug- drug interactions and associated factors with it. The search was conducted from August 22-25, 2019 and all published and unpublished articles available online until the day of data collection were considered.Results A total of 14 studies were included for systematic review and meta-analysis. From 14 studies, 5761 patients were included and a total of 8717 potential drug- drug interactions were found in 3259 of patients. The prevalence patients with potential drug- drug interactions in Ethiopian Hospitals were found to be 72.2% (95% confidence interval: 59.1%, 85.3%). Based on severity, the prevalence of potential drug- drug interactions were 25.1%, 52.8%, 16.9% and 1.27% for major, moderate, minor potential drug- drug interactions and contraindications respectively. The factors associated with potential drug- drug interactions were related to patient characteristics such as polypharmacy, age, comorbid disease and hospital stay.Conclusion There is a high prevalence of potential drug- drug interactions in Ethiopian Hospitals. From this the most prevalent drug- drug interactions were moderate severity, 52.8%. Polypharmacy, age, comorbid disease and hospital stay were the risk factors associated with potential drug- drug interactions.
Optimal cut-off points after a daily meal corresponding to fasting goal levels of LDL-C and non-HDL-C in Chinese patients with coronary heart disease
Authors: Guo Li-Ling , Chen Yan-qiao , Lin Qiu-zhen , Tian Feng , Xiang Qun-Yan , Zhu Li-yuan , Liu Ling , Xu Jin 
Published: January 2020

Abstract
Background: Although the detection of non-fasting blood lipids has been recommended in patients with coronary heart disease (CHD), the non-fasting cut-off points corresponding to the fasting goals of LDL-C < 1.8 mmol/Land non-HDL-C < 2.6 mmol/L, respectively, have not been explored. Methods: This study enrolled 397 inpatients with CHD. One hundred and ninety-seven patients took statins for < 1 month (m) or did not take any statin before admission (i.e. CHD1 group), while 204 patients took statins for ≥ 1 m before admission (i.e. CHD2 group). Blood lipid levels were measured at 0 h, 2 h, and 4 h after a daily breakfast. Results: Non-fasting low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) levels significantly decreased after a daily meal ( P < 0.05). Both fasting and non-fasting LDL-C or non-HDL-C levels were significantly lower in the CHD2 group. The percent attainment of LDL-C < 1.8 mmol/L at 2 h or 4 h after a daily breakfast was significantly higher than that of its fasting point ( P < 0.05), whereas that of non-HDL-C < 2.6 mmol/L was significantly higher only at 4 h ( P < 0.05). Analysis of c-statistic showed that non-fasting cut-off points for LDL-C and non-HDL-C were 1.5 mmol/L and 2.4 mmol/L, corresponding to their fasting goal levels of 1.8 mmol/L and 2.6 mmol/L, respectively. When postprandial LDL-C and non-HDL-C goal attainments were re-evaluated by non-fasting cut-off points, there were no significant differences in percent attainment between fasting and non-fasting states. Conclusions: Determination ofnon-fasting cut-off points is important to evaluate the efficacy of cholesterol-lowering therapy if blood lipids are detected after a daily meal.
The Experience of Patient-Related Violence Against Emergency Department Nurses in the United States: A Phenomenological Pilot Study
Authors: Al-Qadi Mahmoud M. 
Published: January 2020

Abstract
Purpose This study described the experiences, thoughts, perceptions, and feelings of emergency department nurses regarding patient-related violence.Design and Methods A descriptive phenomenological research approach was adopted to collect data through unstructured interviews. Three participants were recruited via word of mouth through colleagues from two different states (North East) in the United States. Data were collected from October to November 2018. Colaizzi’s phenomenological methodology was adopted to analyze the interview content.Findings Seven themes emerged from the analysis of the data: physical violence, take care of patients regardless of their behavior, communication skills, lack of training and educational intervention, contributing factor: long waiting times, expletive forms of verbal abuse and threatening behaviors, and the impact of violent behavior on nurses led to feelings of negative emotions.Conclusions Provide training to ED nurses on how to handle violence situations and the employers has to implement policies to make the workplace safe for both nurses and patients. The findings of this study highlight the urgency of taking a realistic approach to preventing workplace violence to organizational leaders.
A dose-response study in mice of a tetravalent recombinant dengue envelope domain III protein secreted from insect cells
Authors: Shao Lijun , Pang Zheng , Bi Yu , Li Zhenhua , Lin Weiping , Li Guolei , Wang Mingling , Guo Yanming , Niu Guoyu 
Published: January 2020

Abstract
Background: DENV is the most globally prevalent mosquito-transmitted virus. Induction of a broadly and potently immune response is desirable for dengue vaccine development. Methods: We constructed a secreted tetravalent EDⅢ protein from eukaryotic cells and established a MAC-ELISA method for DENV diagnosis. This work aimed to evaluate the immune responses in mice of several formulations of rEDIII containing different amounts of the tetravalent protein. Results: We demonstrated that the tetravalent protein induced humoral immunity against all four serotypes of DENV, even at the lowest dose assayed. Besides, cellular immunities against DENV-1 and DENV-2 were elicited by medium dose group. Importantly, the immune responses induced by the tetravalent formulation were functional in clearing DENV-2 in circulation of mice. Conclusions: We believe that the tetravalent formulation of secreted EDⅢ protein is a potential vaccine candidate against DENV and suggest further detailed studies of this formulation in nonhuman primates. Keywords: Dengue virus; Tetravalent; Humoral immunity; Cellular immunity; Vaccine
The impact of early neuraminidase inhibitor therapy on clinical outcomes in patients hospitalised with influenza A-related pneumonia: a multicenter, retrospective study
Authors: Chen Liang , Han Xiudi , Li YanLi , Zhang Chunxiao , Xing Xiqian 
Published: January 2020

Abstract
Background Guidelines emphasize prompt antiviral treatment in severe influenza patients. Although nearly a 50% of severe influenza present with pneumonia, the effect of early (≤ 2 days after illness onset) neuraminidase inhibitor (NAI) use on the clinical outcomes of influenza A-related pneumonia (FluA-p) has rarely been assessed. And there is limited data about the administration of NAIs in the real-world management of Flu-p in China.Methods Data of patients hospitalised with FluA-p from five teaching hospitals in China from 1 January 2013 to 31 December 2018 were reviewed retrospectively. The impact of early NAI therapy on the outcomes in FluA-p patients, and the indications of early NAI administration by clinicians were evaluated by logistic regression analysis.Results Totally, 693 FluA-p patients were included. Of these patients, 33.5% (232/693) were treated early. After adjusting for weighted propensity scores for treatment, systemic corticosteroid and antibiotic use, a multivariate logistic regression model showed that early NAI therapy was associated with decreased risk for invasive ventilation [ odds ratio ( OR ) 0.511, 95% confidence interval (CI) 0.312–0.835, p = 0.007) and 30-day mortality ( OR 0.533, 95% CI 0.210–0.807, p < 0.001) in FluA-p patients. A multivariate logistic regression model confirmed early NAI use ( OR 0.415, 95% CI 0.195–0.858, p = 0.001) was a predictor for 30-day mortality in FluA-p patients and a positive rapid influenza diagnostic test was the only indication ( OR 3.586, 95% CI 1.259–10.219, p < 0.001) related to the prescription of early NAI by clinicians.Conclusions Early NAI therapy is associated with better outcomes in FluA-p patients. Improved education and training of clinicians on the guidelines of influenza are needed.