bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proportion and Factors that Associate with Incidence of Hepatotoxicity in Rheumatoid Arthritis Patients Treated with Methotrexate in RSCM Year 2013−2015
Authors: Prathitasari Rahma Anindya , Isbagio Harry 
Published: May 2020

Background Rheumatoid arhtirtis (RA) is a chronic autoimmune disease that mainly attacks joints. It may causes joint deformities which leads to lower quality of life of RA patients. RA is treated with metothrexate (MTX) which inhibiting disease progression. MTX is known for its hepatotoxicity side effect, which is described by an elevation of aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) beyond the upper normal limit. Factors that may enhance hepatotoxicity are gender, age, cummulative dose of MTX, and duration therapy of MTX. Prevalence of hepatotoxicity caused by MTX therapy in RA patients in Indonesia is still unknown. The objective of this research is to know the proportion of hepatotoxicity and its associations with the factors that may enhance hepatotoxicity caused by MTX therapy in RA patients in RSCM.Method Data about gender, age, cummulative dose and duration therapy of MTX are obtained from 115 RA patients' medical records.Result Proportion of hepatotoxicity in RA patients treated with MTX in RSCM is 42.60%. Gender, age, cummulative dose and duration therapy of MTX do not significantly enhance hepatotoxicity (p>0.05).Conclusion In conclusion gender, age, cummulative dose and duration therapy of MTX do not have association with hepatotoxicity in RA patients treated with MTX. Keywords: Rheumatoid Arthritis, Methotrexate, Hepatotoxicity
The Differences in Serum Complements and Anti-dsDNA Levels between Renal and Non-renal Manifestations in Systemic Lupus Erythematosus
Authors: Suryana Bagus Putu Putra , Rosita Lya , Djais Nursamsu , Hasanah Dian 
Published: May 2020

Background. Systemic lupus erythematosus (SLE) has diverse clinical manifestations, including renal and non-renal. Renal manifestation is related to significant morbidity and mortality. SLE is also characterized by serological aberrations, including levels of complement C3, C4 and anti-dsDNA, but the association of them with clinical manifestations including renal and non-renal is unclear. This study investigated the associations of C3, C4 and anti-dsDNA levels with renal and non-renal manifestations in SLE patients.
Method. A cross-sectional study was conducted in the Polyclinic of Rheumatology, Dr. Saiful Anwar Hospital Malang. A number of 43 subjects fulfilled the 1997 American College of Rheumatology criteria participated in this study, that consisted of 11 patients with renal manifestation and 32 patients with non-renal manifestations. Serum C3 and C4 levels were measured using immunoturbidimetry, and serum anti-dsDNA levels were measured using enzyme-linked immunosorbent assays (ELISA). The independent T-test was used to compare C3 levels and the Mann-Whitney U test was used to compare C4 and anti-dsDNA levels between groups.
Result. SLE with renal manifestation had significant lower levels of serum C3 compare to non-renal manifestations (mean ± SD: 71.27 ± 32.65 mg/dL and 94.47 ± 26.29 mg/dL respectively, p=0.022). SLE with renal manifestation also had significantly lower levels of serum C4 compare to non-renal manifestations (mean ± SD: 14.55 ± 8.20 mg/dL and 25.50 ± 11.05 mg/dL respectively, p=0.002). Conversely, SLE with renal manifestation had significantly higher levels of serum anti-dsDNA compare to non-renal manifestations (mean ± SD: 249.27 ± 240.34 IU/mL and 109.91 ± 166.11 IU/mL respectively, p=0.014).
Conclusion. SLE patients with renal manifestation have significantly lower levels of serum C3 and C4 and a higher level of serum anti-dsDNA than SLE patients with non-renal manifestations.
Correlation Between Cognitive Function with Disease Activity of Systemic Lupus Erythematosus Patients in Dr. Hasan Sadikin Hospital Bandung: An Analytical Cross-Sectional Study
Authors: Saepudin Aep , Ong Paulus Anam , Hidayat Syarief , Rahmadi Andri Reza , Hamijoyo Laniyati 
Published: May 2020

Background: Cognitive dysfunction was found in 55-80% Neuropsychiatry Systemic Lupus Erythematosus (NPSLE) patients. Serious concern from clinicans was needed as its impact to patient’s quality of life. Disease activity is expected to be affecting patient’s cognitive function. Previous studies regarding correlation between disease activity and cognitive dysfunction showed various results. This study aimed to evaluate the correlation between disease activity and cognitive function in SLE patients.Methods: This study is an analytical cross-sectional study. Subjects were SLE patients at the rheumatology clinic of Dr. Hasan Sadikin Hospital Bandung during June-August 2017. Subject’s evaluations included disease activity assessment using SLE disease activity index-2K (SLEDAI-2K) and cognitive function assessment using MoCA-Ina test. Data were analyzed by using Spearman Rank correlation test. Results: Mean age of the subjects was 31 ± 8 years old, most of them were senior high school graduates (65.8 %) and median length of study was 12 years. Subject’s median duration of illness was 44 months. Their MoCA-Ina median score was 25, while SLEDAI-2K median score was 6. Cognitive dysfunctions were found in more than half of subjects (52.63%), which memory domain (78.95%) was most frequently impaired. Most of subjects were patients with active SLE (63.2%). Correlation test showed there was no correlation between SLEDAI-2K score and MoCA-Ina score (rs=0.023, p=0.445).Conclusion: There was no correlation between disease activity (SLEDAI-2K score) and cognitive function (MoCA-Ina score).
Keywords: Cognitive dysfunction, MoCA-Ina, Systemic lupus erythematosus, SLEDAI-2K
PENEGAKAN DISIPLIN GUNA MEMINIMALISIR TINGKAT PELANGGARAN DISIPLIN ANGGOTA SESUAI UNDANG-UNDANG NOMOR 25 TAHUN 2014 TENTANG HUKUM DISIPLIN MILITER DI GARNISUN III SURABAYA
Authors: . Rumadi 
Published: May 2020

Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis Pelaksanaan Penegakan Disiplin Guna Meminimalisir Tingkat Pelanggaran Disiplin Anggota Di Kogartap III/Surabaya dan mendeskripsikan dan menganalisis faktor yang mendorong dan menghambat Penegakan Disiplin Guna Meminimalisir Tingkat Pelanggaran Disiplin Anggota. Hasil penelitian menunjukkan dalam pelaksanaannya bentuk pelanggaran hukum yang terjadi di wilayah Kogartap III/Surabaya yang sering terjadi dibagi menjadi dua yang pertama adalah pelanggaran dalam satuan, dan yang di luar satuan . Penyelesaian Pelanggaran Hukum Disiplin Prajurit TNI pada kogartap III dilaksanakan melalui kegiatan: pemeriksaan, penjatuhan hukuman, pelaksanaan hukuman dan pencatatan dalam buku hukuman. Alat bukti yang sah yang berlaku dalam Penyelesaian Pelanggaran Hukum Disiplin Prajurit TNI meliputi barang bukti, surat, informasi elektronik dan/atau dokumen elektronik, keterangan saksi, keterangan ahli dan keterangan tersangka

Kata Kunci: Penegakkan Disiplin, Pelanggaran Disiplin Prajurit
KONTRAK INTERNASIONAL YANG BERDASARKAN ASAS KEBEBASAN BERKONTRAK
Authors: Chrisdanty Febry 
Published: May 2020

Orang sebagai subyek hukum dan Perjanjian merupakan sesuai yang tidak dapat dipisahkan, meskipun terkadang orang sendiri merasa tidak sedang melakukan suatu perjanjian. Kehidupan sehari-hari selama itu berkaitan dengan suatu janji atau prestasi, artinya bahwa orang tersebut telah membuat perjanjian dengan pihak lain. Perjanjian atau kontrak dapat dibuat secara lisan maupun tertulis yang kemudian mengikat kedua belah pihak. Dalam dunia bisnis, aktivitas bisnis tidak terlepas dari perjanjian antara para pelaku usaha yang umumnya diwujudkan dalam bentuk kontrak. Pembuatan kontrak sendiri juga menganut asas perjanjian pada umumnya yaitu salah satunya asas kebebasan berkontrak. Asas kebebasan berkontrak ini berlaku secara umum baik untuk kontrak local maupun kontrak internasional. Kebebasan berkontrak berkaitan dengan kemungkinan dapat tidaknya orang membuat kontrak dengan pihak lain, kapanpun dimanapun dan tentang apapun. Namun kebebasan tersebut tidak dapat berlaku secara multak karena tetap terbatas dengan hal-hal yang telah diatur sebelumnya.

Kata Kunci : Perjanjian, Kontrak, asas, kebebasan
DFT Mechanistic Study on the Reaction of Benzenesulfonyl Azides with Oxabicyclic Alkenes
Authors: Akuamoah Daniel Aboagye , Tia Richard , Adei Evans 
Published: May 2020

The reaction of benzenesulfonyl azides with oxabicyclic alkenes to form aziridines, reported by Chen et al (J. Org. Chem. 2019, 84, 18, 11863-11872), could proceed via initial [3+2] cycloaddition to form triazoline intermediates followed by dinitrogen cleavage or via initial dinitrogen cleavage of the benzenesulfonyl azide to afford a nitrene intermediate followed by insertion of this species into the olefinic bond of the oxabicyclic alkene. Calculations at the DFT M06-2X/6-311G+(d,p) level show that the initial [3+2] cycloaddition has barriers of 17.3 kcal/mol (endo) and 10.2 kcal/mol (exo) while the initial nitrogen extrusion step has a barrier of 38.9 kcal/mol. The rate-determining step along the former pathway is the dinitrogen cleavage from triazoline cycloadducts which has barriers of 32.3 kcal/mol (endo) and 38.6 kcal/mol (exo) and that along the latter pathway is dinitrogen cleavage from benzenesulfonyl azide with an activation of barrier of 38.9 kcal/mol. The [3+2] addition of benzenesulfonyl azide with oxabicyclic alkene to afford endo and exo triazoline intermediates is kinetically favored over the dinitrogen cleavage from benzenesulfonyl azide by 21.6 and 28.1 kcal/mol for endo and exo pathway respectively. Thus, the preferred pathway for the reaction of oxabicyclic alkene with benzenesulfonyl azide is via initial [3+2] addition followed by dinitrogen cleavage, contrary to the proposal by Chen et al. The lower activation barrier for the dinitrogen extrusion step leading to endo aziridine compared to exo isomer means that the endo product will be formed as the major product, confirming the experimental observation. The position of substituents on the benzene group of the benzenesulfonyl azide greatly affects the endo / exo diastereoselectivity.
AGE AND GENDER-RELATED DIFFERENCES IN MONEY BELIEFS AND ATTITUDES
Authors: Angelova Natasha Virmozelova 
Published: May 2020

This article presents research on the relationships of gender role identification, biological sex, and age to the beliefs and behaviors about money. The participants were 240 whose age varied from 17 to 91 years (M = 38.68, SD = 1.81). Bulgarian adaptations of Bem Sex-Role Inventory (BSRI) and Furnham's Money Beliefs and Behavior Scale (MBBS) were used. The results indicated that people with different gender role patterns (masculine type, feminine type, androgynous type, undifferentiated type) differed in their beliefs and behaviors towards money. According to the results of this research, biological sex was related to male attitudes and beliefs that money could be the main purpose and value, and may be used to demonstrate excellence. The data showed that women tended to feel more tension, anxiety, and guilt when spending money, and also perceived money as a means of security and protection. The assumption that the participants from different age groups would have different beliefs and attitudes about money was also confirmed.
Optimalisasi Leadership dan Sarana Belajar Sebagai Pilar Pendidikan Sekolah Alam Melalui Inisiasi Outbound di Sekolah Alam Rumbai Pekanbaru
Authors: Kurnia Vilmala Berry , Hafid Afdhil , Hamka Defrizal 
Published: May 2020

One of the shortcomings in the implementation of education in schools is the lack of a forum that can facilitate student leadership which is integrated with learning in the Classroom. In general, Leadership is carried out in extracurricular activities in schools. The implementation of Leadership training has limited time in its implementation and is felt to be less than optimal. Leadership is separate from student learning activities. UMRI has experts in the field of Science (IPA) and Education under the auspices of the Faculty of Teacher Training and Education and the field of Technology Design under the auspices of the Faculty of Computer Science who can contribute their knowledge to the Leadership optimization program and the means of learning together with nature through outbound initiation at the Rumbai Nature School. The main activity that would be carried out in this program is to design and create an integrated outbound facility with the Natural Joint Learning facilities in the Sekolah Alam Rumbai environment. The output that is expected to be generated from this activity is the availability of integrated outbound facilities to support Leadership through outbound and scientific logic through Student Learning Together Nature can be optimized.
Cegah Penyakit ISPA di Puskesmas Kecamatan Limapuluh Kota Pekanbaru
Authors: Yuyun Priwahyuni  , Sinaga Erisca feroza , Christine Vita Gloria  , Agus Alamsyah  , Ikhtiyaruddin Ikhtiyaruddin  , Iqlima Afif Azizah  
Published: May 2020

Infeksi Saluran Pernapasan Akut (ISPA) merupakan penyakit saluran pernapasan atas atau bawah yang disebabkan agen infeksius. Penyakit-penyakit berbasis lingkungan memang masih merupakan penyebab utama kematian di Indonesia. Penyakit ISPA di Indonesia berada pada 10 daftar penyakit terbanyak di rumah sakit. penyebab ISPA berkaitan dengan kondisi lingkungan tempat tinggal penderita. Tujuan PKM adalah untuk meningkatkan pengetahuan dan pemahaman masyarakat bagaimana mengenali faktor resiko penularan penyakit ispa. Metode PKM penyuluhan dan pendidikan kesehatan tentang faktor resiko terserang penyakit ISPA dan pecegahan dari penularannya, sasaran PKM masyarakat di Puskesmas Kecamatan Limapuluh Kota Pekanbaru. Kegiatan dilaksanakan Sabtu 30 November 2019. Hasil kegiatan PKM didapat bahwa dari 50 masyarakat yang mengikuti kegiatan tersebut, 80% masyarakat mengetahui penyakit ISPA dan 40% memahami cara pencegahan dan pengobatan penyakit ISPA
Pengaruh Pelatihan dan Motivasi Terhadap Kinerja Karyawan PT. Bank Perkreditan Rakyat Chandra Mukti Artha Yogyakarta
Authors: Shofi'unnafi S. 
Published: May 2020

Tujuan penelitian ini untuk mengidentifikasi pengaruh pelatihan dan motivasi terhadap kinerja karyawan. Penelitian ini menggunakan metode deskriptif kuantitatif. Data dikumpulkan dengan menyebarkan kuesioner kepada responden. Analisis data menggunakan regresi linier berganda dengan melibatkan sampel sebanyak 120 karyawan dan supervisor di PT. Bank Perkreditan Rakyat Chandra Mukti Artha Yogyakarta. Hasil penelitian menunjukan bahwa pelatihan dan motivasi berpengaruh terhadap kinerja karyawan. Temuan penelitian ini memberikan implikasi bahwa program pelatihan kepada karyawan dapat meningkatkan keterampilan teknikal maupun non-teknikal. Selain itu, motivasi karyawan dapat ditingkatkan melalui pemberian kompensasi agar karyawan bisa bekerja lebih baik dan produktif.
Detection of Polarization due to Cloud Bands in the Nearby Luhman 16 Brown Dwarf Binary
Authors: Millar-Blanchaer Maxwell A. , Girard Julien H. , Karalidi Theodora , Marley Mark S. , van Holstein Rob G. , Sengupta Sujan , Mawet Dimitri , Kataria Tiffany , Snik Frans , Boer Jos de , Jensen-Clem Rebecca , Vigan Arthur , Hinkley Sasha 
Published: May 2020

Abstract
Brown dwarfs exhibit patchy or spatially varying banded cloud structures that are inferred through photometric and spectroscopic variability modeling techniques. However, these methods are insensitive to rotationally invariant structures, such as the bands seen in Jupiter. Here, we present H-band Very Large Telescope/NaCo linear polarization measurements of the nearby Luhman 16 L/T transition binary, which suggest that Luhman 16A exhibits constant longitudinal cloud bands. The instrument was operated in pupil tracking mode, allowing us to unambiguously distinguish between a small astrophysical polarization and the ∼2% instrumental linear polarization. We measure the degree and angle of linear polarization of Luhman 16A and B to be p

A
= 0.031% ± 0.004% and ψ

A
= −32° ± 4°, and p

B
= 0.010% ± 0.004% and

, respectively. Using known physical parameters of the system, we demonstrate that an oblate homogeneous atmosphere cannot account for the polarization measured in Luhman 16A, but could be responsible for that of the B component. Through a nonexhaustive search of banded cloud morphologies, we demonstrate a two-banded scenario that can achieve a degree of linear polarization of p = 0.03% and conclude that the measured polarization of the A component must be predominantly due to cloud banding. For Luhman 16B, either oblateness or cloud banding could be the dominant source of the measured polarization. The misaligned polarization angles of the two binary components tentatively suggest spin–orbit misalignment. These measurements provide new evidence for the prevalence of cloud banding in brown dwarfs while at the same time demonstrating a new method—complementary to photometric and spectroscopic variability methods—for characterizing the cloud morphologies of substellar objects without signs of variability.
Cosmological Model Insensitivity of Local H0 from the Cepheid Distance Ladder
Authors: Dhawan S. , Brout D. , Scolnic D. , Goobar A. , Riess A. G. , Miranda V. 
Published: May 2020

Abstract
The observed tension (∼9% difference) between the local distance ladder measurement of the Hubble constant, H
0, and its value inferred from the cosmic microwave background could hint at new, exotic, cosmological physics. We test the impact of the assumption about the expansion history of the universe (

) on the local distance ladder estimate of H
0. In the fiducial analysis, the Hubble flow Type Ia supernova (SN Ia) sample is truncated to z < 0.15, and the deceleration parameter (q
0) is fixed to −0.55. We create realistic simulations of the calibrator and Pantheon samples, and account for a full systematics covariance between these two sets. We fit several physically motivated dark-energy models, and derive combined constraints from calibrator and Pantheon SNe Ia and simultaneously infer H
0 and dark-energy properties. We find that the assumption on the dark-energy model does not significantly change the local distance ladder value of H
0, with a maximum difference (ΔH
0) between the inferred value for different models of 0.47 km

, i.e., a 0.6% shift in H
0, significantly smaller than the observed tension. Additional freedom in the dark-energy models does not increase the error in the inferred value of H
0. Including systematics covariance between the calibrators, low-redshift SNe, and high-redshift SNe can induce small shifts in the inferred value for H
0. The SN Ia systematics in this study contribute ≲0.8% to the total uncertainty of H
0.
The ELM Survey South. I. An Effective Search for Extremely Low Mass White Dwarfs
Authors: Kosakowski Alekzander , Kilic Mukremin , Brown Warren R. , Gianninas Alexandros 
Published: May 2020

Abstract
We begin the search for extremely low mass (M ≤ 0.3M
⊙, ELM) white dwarfs (WDs) in the southern sky based on photometry from the VST ATLAS and SkyMapper surveys. We use a similar color selection method as the Hypervelocity star survey. We switched to an astrometric selection once Gaia Data Release 2 became available. We use the previously known sample of ELM white dwarfs to demonstrate that these objects occupy a unique parameter space in parallax and magnitude. We use the SOAR 4.1 m telescope to test the Gaia-based selection, and identify more than two dozen low mass white dwarfs, including six new ELM white dwarf binaries with periods as short as 2 h. The better efficiency of the Gaia-based selection enables us to extend the ELM Survey footprint to the southern sky. We confirm one of our candidates, J0500−0930, to be the brightest (G = 12.6 mag) and closest (d = 72 pc) ELM white dwarf binary currently known. Remarkably, the Transiting Exoplanet Survey Satellite (TESS) full-frame imaging data on this system reveals low-level (<0.1%) but significant variability at the orbital period of this system (P = 9.5 hr), likely from the relativistic beaming effect. TESS data on another system, J0642−5605, reveals ellipsoidal variations due to a tidally distorted ELM WD. These demonstrate the power of TESS full-frame images in confirming the orbital periods of relatively bright compact object binaries.
Magnetar as Central Engine of Gamma-Ray Bursts: Quasi-universal Jet, Event Rate, and X-Ray Luminosity Function of Dipole Radiations
Authors: Xie Wen-Jin , Zou Le , Liu Hong-Bang , Wang Shan-Qin , Liang En-Wei 
Published: May 2020

Abstract
Early shallow-decaying X-ray afterglows of gamma-ray bursts (GRBs) may be attributed to the dipole radiations of newly born magnetars. Assuming that the GRB jets powered by magnetars are quasi-universal, we find that the jet structure can be parameterized as a uniform jet with a luminosity of

(1σ) and an opening angle

(50% confidence level), surrounding by a power-law decay component with an index of

(1σ). The inferred local GRB rate is ρ = 9.6 Gpc−3 yr−1 by including both the typical GRBs and LL-GRBs as the same population. The typical viewing angle is 3.3°, and may be 20° ∼ 30° for LL-GRBs. The X-ray luminosity function of the dipole radiation wind can be empirically described by a broken power-law function with indices

and

broken at

. In the case where the wind outflow is collimated and coaxial with the GRB jet, we find that the wind structure is similar to the GRB jet, i.e.,

,

, and

. The observed correlation between the prompt gamma-ray luminosity and X-ray luminosity of the wind may result from the viewing angle effect in such a jet–wind system. A discussion on surveys using the X-ray instruments on board the Einstein Probe mission in the soft X-ray band for the jet and wind emission is also presented.
Evidence for Proton Acceleration up to TeV Energies Based on VERITAS and Fermi-LAT Observations of the Cas A SNR
Authors: Abeysekara A. U. , Archer A. , Benbow W. , Bird R. , Brose R. , Buchovecky M. , Buckley J. H. , Chromey A. J. , Cui W. , Daniel M. K. , Das S. , Dwarkadas V. V. , Falcone A. , Feng Q. , Finley J. P. , Fortson L. , Gent A. , Gillanders G. H. , Giuri C. , Gueta O. , Hanna D. , Hassan T. , Hervet O. , Holder J. , Hughes G. , Humensky T. B. , Kaaret P. , Kar P. , Kelley-Hoskins N. , Kertzman M. , Kieda D. , Krause M. , Krennrich F. , Kumar S. , Lang M. J. , Maier G. , Moriarty P. , Mukherjee R. , Nievas-Rosillo M. , O’Brien S. , Ong R. A. , Park N. , Petrashyk A. , Pfrang K. , Pohl M. , Pueschel E. , Quinn J. , Ragan K. , Reynolds P. T. , Richards G. T. , Roache E. , Sadeh I. , Santander M. , Sembroski G. H. , Shahinyan K. , Sushch I. , Weinstein A. , Wilcox P. , Wilhelm A. , Williams D. A. , Williamson T. J , Zitzer B. , Ghiotto A. 
Published: May 2020

Abstract
We present a study of γ-ray emission from the core-collapse supernova remnant Cas A in the energy range from 0.1 GeV to 10 TeV. We used 65 hr of the Very Energetic Radiation Imaging Telescope Array System (VERITAS) data to cover 200 GeV–10 TeV, and 10.8 yr of Fermi-Large Area Telescope (LAT) data to cover 0.1–500 GeV. The spectral analysis of Fermi-LAT data shows a significant spectral curvature around 1.3 ± 0.4stat GeV that is consistent with the expected spectrum from pion decay. Above this energy, the joint spectrum from Fermi-LAT and VERITAS deviates significantly from a simple power law, and it is best described by a power law with a spectral index of 2.17 ± 0.02stat and a cutoff energy of 2.3 ± 0.5stat TeV. These results, along with radio, X-ray, and γ-ray data, are interpreted in the context of leptonic and hadronic models. Assuming a one-zone model, we exclude a purely leptonic scenario and conclude that proton acceleration up to at least 6 TeV is required to explain the observed γ-ray spectrum. From modeling of the entire multiwavelength spectrum, a minimum magnetic field inside the remnant of B
min ≈ 150 μG is deduced.