bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraperitoneal Versus Ultrasound Guided Transversus Abdominis Plane Block by Bupivacaine-Magnesium Sulphate for Pain Relieafter Laparoscopic Cholecystectomy
Authors: Hamoda Nashwa I. , Tatawy Hesham I. El , Shmaa Nagat S. El , Okab Mohammad I. 
Published: October 2020

Background and Aim: Intraperitoneal (IP) administration of local anesthetic is considered a method of control of visceral component of pain. This method cannot be used as sole agent for pain relief after laparoscopic cholecystectomy (LC). Transversus Abdominis Plane block (TAP) becomes a useful anesthetic technique in the treatment of postoperative pain after the LC surgery. The aim of the study was to compare between IP bupivacaine –Magnesiu;m Sulfate (MgSO4) and TAP by bupivacaine- MgSO4 for pain relief after LC.
Materials and Methods: This was a randomized double blinded study on sixty patients ASA I &II, age from 18 to 60 years old, undergoing elective LC surgery were randomly classified into two equal groups (30 patients in each group). Group I: IP instillation of 30 ml [15 ml bupivacaine 0.5% (75mg) plus 2.5ml MgSO4 (250 mg) plus 12.5 normal saline].Group II: Ultrasound guided subcostal TAP block was performed by using total volume 20 ml on each side [10 ml bupivacaine %0.5 (50 mg) plus 1.5ml MgSO4 (150 mg) plus 8.5 normal saline]. Heart rate (HR) and Mean Arterial Blood Pressure (MAP) were measured at 5 min before induction and every 15min after induction till the end of operation and then every 5 min for the first 20 mins after administration of study drugs then they recorded at interval of 30mins, 1hr, 2hrs, 4hr and 6hr postoperative. Numeric Rating Scale (NRS) at emergence, 2, 4, 8, 12, 18 and 24hr after recovery, first rescue analgesia time, postoperative analgesic consumption, length of hospital stay(LOS), patients’ satisfaction and post-operative complications were recorded.
Results: There were insignificant differences in HR and MAP between the two groups. There was a significant decrease in NRS at 4hr and 8 hr in group II than group I. There was a significant decrease regarding to time of first rescue analgesia, total postoperative analgesic consumption and LOS in group II compared to group I. There was a significant increase of satisfaction in group II compared to group I. There was an insignificant difference between both groups in nausea, vomiting, hypotension, bradycardia, bradypnea or MgSO4 toxicity.
Conclusion: TAP by bupivacaine-MgSO4 has superior analgesia, longer duration, less postoperative analgesic consumption and more satisfaction in patients undergoing LC than IP block by bupivacaine-MgSO4.
Políticas Culturais no Brasil: O Edital Circula Minas e o Soft Power mineiro
Authors: Tavares Thiago Rodrigues , Castro Vanessa Gomes de 
Published: October 2020

<p>O presente artigo visa refletir sobre as políticas públicas culturais, pelo viés do <em>soft power, </em>termo cunhado por Joseph Samuel Nye Jr., no intuito de definir a capacidade de influenciar os outros a fazer o que se deseja pela atração, ao invés da coerção, “poder brando”. Nesse sentido, a identidade cultural é um dos elemento que compõem o poder brando de um país, uma vez que o <em>soft power</em> possibilita a utilização da produção cultural enquanto elemento de diplomacia e fomento de boas relações externas. Desse modo, será analisado o edital Circula Minas, programa de intercâmbio promovido pelo governo de Minas Gerais, por intermédio da Secretaria de Estado de Cultura, do ano de 2018. Esse edital de fomento a cultura proporciona o estreitamento das relações intencionais, a troca de experiências e a difusão da cultura mineira em diversas áreas.</p>
Beam angle comparison for distal esophageal carcinoma patients treated with intensity‐modulated proton therapy
Authors: Feng Hongying , Sio Terence T. , Rule William G. , Bhangoo Ronik S. , Lara Pedro , Patrick Christopher L. , Korte Shawn , Fatyga Mirek , Wong William W. , Schild Steven E. , Ashman Jonathan B. , Liu Wei 
Published: October 2020

AbstractPurposeTo compare the dosimetric performances of intensity‐modulated proton therapy (IMPT) plans generated with two different beam angle configurations (the Right–Left oblique posterior beams and the Superior–Inferior oblique posterior beams) for the treatment of distal esophageal carcinoma in the presence of uncertainties and interplay effect.Methods and MaterialsTwenty patients’ IMPT plans were retrospectively selected, with 10 patients treated with the R‐L oblique posterior beams (Group R‐L) and the other 10 patients treated with the S‐I oblique posterior beams (Group S‐I). Patients in both groups were matched by their clinical target volumes (CTVs—high and low dose levels) and respiratory motion amplitudes. Dose‐volume‐histogram (DVH) indices were used to assess plan quality. DVH bandwidth was calculated to evaluate plan robustness. Interplay effect was quantified using four‐dimensional (4D) dynamic dose calculation with random respiratory starting phase of each fraction. Normal tissue complication probability (NTCP) for heart, liver, and lung was calculated, respectively, to estimate the clinical outcomes. Wilcoxon signed‐rank test was used for statistical comparison between the two groups.ResultsCompared with plans in Group R‐L, plans in Group S‐I resulted in significantly lower liver Dmean and lung V30Gy[RBE] with slightly higher but clinically acceptable spinal cord Dmax. Similar plan robustness was observed between the two groups. When interplay effect was considered, plans in Group S‐I performed statistically better for heart Dmean and V30Gy[RBE], lung Dmean and V5Gy[RBE], and liver Dmean, with slightly increased but clinically acceptable spinal cord Dmax. NTCP for liver was significantly better in Group S‐I.ConclusionsIMPT plans in Group S‐I have better sparing of liver, heart, and lungs at the slight cost of spinal cord maximum dose protection, and are more interplay‐effect resilient compared to IMPT plans in Group R‐L. Our study supports the routine use of the S‐I oblique posterior beams for the treatments of distal esophageal carcinoma.
Fabrication of a pediatric torso phantom with multiple tissues represented using a dual nozzle thermoplastic 3D printer
Authors: Mille Matthew M. , Griffin Keith T. , Maass‐Moreno Roberto , Lee Choonsik 
Published: October 2020

AbstractPurposeTo demonstrate an on‐demand and nearly automatic method for fabricating tissue‐equivalent physical anthropomorphic phantoms for imaging and dosimetry applications using a dual nozzle thermoplastic three‐dimensional (3D) printer and two types of plastic.MethodsTwo 3D printing plastics were investigated: (a) Normal polylactic acid (PLA) as a soft tissue simulant and (b) Iron PLA (PLA‐Fe), a composite of PLA and iron powder, as a bone simulant. The plastics and geometry of a 1‐yr‐old computational phantom were combined with a dual extrusion 3D printer to fabricate an anthropomorphic imaging phantom. The volumetric fill density of the 3D‐printed parts was varied to approximate tissues of different radiographic density using a calibration curve relating the printer infill density setting to measured CT number. As a demonstration of our method we printed a 10 cm axial cross‐section of the computational phantom’s torso at full scale. We imaged the phantom on a CT scanner and compared HU values to those of a 1‐yr‐old patient and a commercial 5‐yr‐old physical phantom.ResultsThe phantom was printed in six parts over the course of a week. The printed phantom included 30 separate anatomical regions including soft tissue remainder, lungs (left and right), heart, esophagus, rib cage (left and right ribs 1 to 10), clavicles (left and right), scapulae (left and right), thoracic vertebrae (one solid object defining thoracic vertebrae T1 to T9). CT scanning of the phantom showed five distinct radiographic regions (heart, lung, soft tissue remainder, bone, and air cavity) despite using only two types of plastic. The 3D‐printed phantom demonstrated excellent similarity to commercially available phantoms, although key limitations in the printer and printing materials leave opportunity for improvement.ConclusionPatient‐specific anthropomorphic phantoms can be 3D printed and assembled in sections for imaging and dosimetry applications. Such phantoms will be useful for dose verification purposes when commercial phantoms are unavailable for purchase in the specific anatomies of interest.
A meta‐analytic review of the Self‐Administered Interview©: Quantity and accuracy of details reported on initial and subsequent retrieval attempts
Authors: Horry Ruth , Hughes Chelsea , Sharma Anagha , Gabbert Fiona , Hope Lorraine 
Published: October 2020

AbstractThe Self‐Administered Interview (SAI©) is designed to elicit detailed witness reports in the aftermath of incidents. In two sets of meta‐analyses, we compared the number of correct details reported, the number of incorrect details reported, and the accuracy of reports provided by witnesses in initial reports (SAI© vs. other reporting formats) and in subsequent accounts (initial SAI© vs. no initial SAI©). The number of comparisons ranged from 15 to 19, (N = 722 to 977). For initial accounts, the SAI© was associated with more correct details and more incorrect details than other reporting formats; accuracy was slightly lower for the SAI© than for other reporting formats. Subsequent accounts were more detailed and accurate for witnesses who had completed an initial SAI© than for those who had not. The SAI© is an effective tool for capturing detailed initial accounts and for preserving witness memory until a formal interview can be conducted.
Stacking of 2D Materials
Authors: Guo Hao‐Wei , Hu Zhen , Liu Zhi‐Bo , Tian Jian‐Guo 
Published: October 2020

Abstract2D layered materials have sparked great interest from the perspective of basic physics and applied science in the past few years. Extraordinarily, many novel stacked structures that bring versatile properties and applications can be artificially assembled, as exemplified by vertical van der Waals (vdW) heterostructures, twisted multilayer 2D materials, hybrid dimensional structures, etc. Compared with the ordinary synthesis process, the stacking technique is a powerful strategy to achieve high‐quality and freely controlled 2D material stacked structures with atomic accuracy. This review highlights the most advanced stacking techniques involving the preparation, transfer, and stacking of high‐quality single crystal 2D materials. Apart from the 2D–2D stacked structures, 2D–0D, 2D–1D, and 2D–3D structures offer a prospective platform for the increasing application of 2D materials. The assembly strategy and physical properties of these stacked structures strongly depend on the factors in the stacking process, including the surface quality, angle control, and sample size. In addition, comparative analysis tables on the techniques involved are also available. The summary of these strategies and techniques will hopefully provide a valuable reference for relevant work.
Tissue Engineered Vascular Graft Recipient Interleukin 10 Status Is Critical for Preventing Thrombosis
Authors: Mirhaidari Gabriel J. M. , Barker Jenny C. , Zbinden Jacob C. , Santantonio Brevan M. , Chang Yu‐Chun , Best Cameron A. , Reinhardt James W. , Blum Kevin M. , Yi Tai , Breuer Christopher K. 
Published: October 2020

AbstractTissue engineered vascular grafts (TEVGs) are a promising technology, but are hindered by occlusion. Seeding with bone‐marrow derived mononuclear cells (BM‐MNCs) mitigates occlusion, yet the precise mechanism remains unclear. Seeded cells disappear quickly and potentially mediate an anti‐inflammatory effect through paracrine signaling. Here, a series of reciprocal genetic TEVG implantations plus recombinant protein treatment is reported to investigate what role interleukin‐10, an anti‐inflammatory cytokine, plays from both host and seeded cells. TEVGs seeded with BM‐MNCs from wild‐type and IL‐10 KO mice, plus unseeded grafts, are implanted into wild‐type and IL‐10 KO mice. Wild‐type mice with unseeded grafts also receive recombinant IL‐10. Serial ultrasound evaluates occlusion and TEVGs are harvested at 14 d for immunohistochemical analysis. TEVGs in IL‐10 KO mice have significantly higher occlusion incidence compared to wild‐type mice attributed to acute (<3 d) thrombosis. Cell seeding rescues TEVGs in IL‐10 KO mice comparable to wild‐type patency. IL‐10 from the host and seeded cells do not significantly influence graft inflammation and macrophage phenotype, yet IL‐10 treatment shows interesting biologic effects including decreasing cell proliferation and increasing M2 macrophage polarization. IL‐10 from the host is critical for preventing TEVG thrombosis and seeded BM‐MNCs exert a significant anti‐thrombotic effect in IL‐10 KO mice.
Ionic‐Liquid‐Based Safe Adjuvants
Authors: Ukidve Anvay , Cu Katharina , Goetz Morgan , Angsantikul Pavimol , Curreri Alexander , Tanner Eden E. L. , Lahann Joerg , Mitragotri Samir 
Published: October 2020

AbstractAdjuvants play a critical role in the design and development of novel vaccines. Despite extensive research, only a handful of vaccine adjuvants have been approved for human use. Currently used adjuvants are mostly composed of components that are non‐native to the human body, such as aluminum salt, bacterial lipids, or foreign genomic material. Here, a new ionic‐liquid‐based adjuvant is explored, synthesized using two metabolites of the body, choline and lactic acid (ChoLa). ChoLa distributes the antigen efficiently upon injection, maintains antigen integrity, enhances immune infiltration at the injection site, and leads to a potent immune response against the antigen. Thus, it can serve as a promising safe adjuvant platform that can help to protect against pandemics and future infectious threats.
Regenerative Superhydrophobic Paper Coatings by In Situ Formation of Waxy Nanostructures
Authors: Cordt Cynthia , Geissler Andreas , Biesalski Markus 
Published: October 2020

AbstractThis scientific−technical approach describes a unique self‐structuring coating material made of wax and polysaccharide derivatives, which results in extremely water‐repellent properties if applied to solid surfaces. When cooling the coating down from the molten state, the material forms a nanostructured superhydrophobic surface within seconds. This possibility of a fast thermally induced regeneration of nanoscale surface textures creates the potential to restore superhydrophobic coating properties even after mechanical damage caused, among others, by long‐term use and complex processing and machining steps. Therefore, this coating material has great potential for engineering applications such as superhydrophobic wettability of paper surfaces. Depending on a particular application, there are different requirements for the interaction of paper with water. The highest possible water resistance, which is achieved by superhydrophobic properties, is a quality feature for a majority of paper products, such as packaging materials or novel construction materials, since the ingress of moisture is a major cause of paper damage.
Implementing Superhydrophobic Surfaces within Various Condensation Environments: A Review
Authors: Singh Navdeep Sangeet , Zhang Jitao , Stafford Jason , Anthony Carl , Gao Nan 
Published: October 2020

AbstractSteam condensation is omnipresent, and inevitable in many industrial processes. A classic example is seen within condensers that are used to liquify various gasses. In consequence, water‐vapor is eventually deposited upon the exterior of heat pipes that passively cool the gas to form a thin film of liquid. This macroscopic film is responsible for the degradation of heat transfer efficiencies. Liquid repellent surfaces can microscopically manipulate the hydrodynamics of formulating condensate to transition toward dropwise/jumping‐droplet condensation. This effect will save operating and maintenance costs of steam condensers within power‐plants, subsequently reducing emissions, operating power, and fuel consumption. However, the challenges associated with the stabilization of dropwise/jumping‐droplet condensation, especially at large subcooling temperatures and high supersaturation ratios, have prohibited the use of liquid repellent surfaces. This review aims to discuss recent improvements and understanding of dropwise/jumping‐droplet condensation surfaces on superhydrophobic surfaces. Numerous examples shall be included, showing experimental and numerical studies of various innovative properties of superhydrophobic structures. In addition, various fabrication techniques of superhydrophobic surfaces that are applicable within industrial systems are discussed. These topics are consolidated to provide guidelines for future research into dropwise/jumping‐droplet condensation on liquid repellent surfaces.
Focusing the future of farming on agroecology
Authors: Franzluebbers Alan J. , Wendroth Ole , Creamer Nancy G. , Feng Gary G. 
Published: October 2020

AbstractThe future of humanity and how agriculture can continue to support the food and fiber needs of a burgeoning population are threatened by agriculture's persistent negative effects on the environment. Essential natural resources that will be needed in increasingly greater capacity are being undermined by agricultural practices that continue to deplete the soil resource base, pollute freshwater and coastal estuaries needed for life support, reduce habitat to support biodiversity, and emit harmful greenhouse gases that compromise our ability to withstand changes to the climate. Solutions to these problems are available in known and increasingly well documented approaches using agroecological principles that manage food production in harmony with nature, not against it. This commentary provides a message that we should be seeking healing of our planet, not just less harm than in the past. It is an important distinction that needs to be considered for the future health of people and the planet.
Lifetime stress and war exposure timing may predict methylation changes at NR3C1 based on a pilot study in a warrior cohort in a small‐scale society in Kenya
Authors: Straight Bilinda , Fisher Georgiana , Needham Belinda L. , Naugle Amy , Olungah Charles , Wanitjirattikal Puntipa , Root Cecilia , Farman Jen , Barkman Todd , Lalancette Claudia 
Published: October 2020

AbstractObjectivesCandidate gene methylation studies of NR3C1 have identified associations with psychosocial adversity, including war trauma. This pilot study (sample sizes from 22 to 45 for primary analyses) examined NR3C1 methylation in a group of Kenyan pastoralist young men in relation to culturally relevant traumatic experiences, including participation in coalitional lethal gun violence.MethodsAdolescent and young adult Samburu men (“warriors”) were recruited for participation. DNA was obtained from whole saliva and methylation analyses performed using mass spectrometry. We performed a data reduction of variables from a standardized instrument of lifetime stress using a factor analysis and we assessed the association between the extracted factors with culturally relevant and cross‐culturally comparative experiences.ResultsCumulative lifetime trauma exposure and forms of violence to which warriors are particularly susceptible were associated with DNA methylation changes in the NR3C1 1F promoter region but not in the NR3C1 1D promoter region. However, sensitivity analyses revealed significant associations between individual CpG sites in both regions and cumulative stress exposures, war exposure timing, and war fatalities.ConclusionsThis study supports the importance of NR3C1 methylation changes in response to challenging life circumstances, including in a global south cultural context that contrasts in notable ways from global north contexts and from the starkly tragic examples of the Rwandan genocide and war‐associated rape explored in recent studies. Timing of traumatic exposure and culturally salient means to measure enduring symptoms of trauma remain important considerations for DNA methylation studies.
Seasonality and interindividual variation in mandrill feeding ecology revealed by stable isotope analyses of hair and blood
Authors: Oelze Vicky M. , Percher Alice M. , Nsi Akoué Gontran , El Ksabi Nory , Willaume Eric , Charpentier Marie J. E. 
Published: October 2020

AbstractMandrills are large‐bodied terrestrial forest primates living in particularly large social groups of several hundred individuals. Following these groups in the wild to assess differences in diet over time as well as among individuals is demanding. We here use isotope analyses in blood and hair obtained during repeated captures of 43 identified free‐ranging mandrills (Mandrillus sphinx) from Southern Gabon, to test how dietary variation relates to the season as well as an individual's age and sex. We measured the stable carbon (δ13C‰) and nitrogen (δ15N‰) isotope ratios in 46 blood and 214 hair section samples as well as from a small selection of mandrill foods (n = 24). We found some seasonal isotopic effects, with lower δ13C values but higher δ15N values observed during the highly competitive long dry season compared to the fruit‐rich long rainy season. Variation in δ13C was further predicted by individual age, with higher δ13C values generally found in younger individuals suggesting that they may consume more high canopy fruit than older individuals, or that older individuals consume more low canopy foliage. The best predictor for δ15N values was the interaction between age and sex, with mature and reproductively active males revealing the highest δ15N values, despite the observation that males consume substantially less animal food items than females. We interpret high δ15N values in these mature male mandrill blood and hair sections to be the result of nutritional stress associated with intense male–male competition, particularly during mating season. This is the first study showing isotopic evidence for nutritional stress in a free‐ranging primate species and may spark further investigations into male mandrill diet and energy balance.
Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
Authors: Arnsten Amy F. T. , Datta Dibyadeep , Del Tredici Kelly , Braak Heiko 
Published: October 2020

AbstractThe etiology of the common, sporadic form of Alzheimer's disease (sAD) is unknown. We hypothesize that tau pathology within select projection neurons with susceptible microenvironments can initiate sAD. This postulate rests on extensive data demonstrating that in human brains tau pathology appears about a decade before the formation of Aβ plaques (Aβps), especially targeting glutamate projection neurons in the association cortex. Data from aging rhesus monkeys show abnormal tau phosphorylation within vulnerable neurons, associated with calcium dysregulation. Abnormally phosphorylated tau (pTau) on microtubules traps APP‐containing endosomes, which can increase Aβ production. As Aβ oligomers increase abnormal phosphorylation of tau, this would drive vicious cycles leading to sAD pathology over a long lifespan, with genetic and environmental factors that may accelerate pathological events. This hypothesis could be testable in the aged monkey association cortex that naturally expresses characteristics capable of promoting and sustaining abnormal tau phosphorylation and Aβ production.