bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistance training preserves high-intensity interval training induced improvements in skeletal muscle capillarization of healthy old men: a randomized controlled trial
Authors: Leuchtmann Aurel B. , Mueller Sandro Manuel , Aguayo David , Petersen Jens A. , Ligon-Auer Maria , Flück Martin , Jung Hans H. , Toigo Marco 
Published: April 2020

AbstractSkeletal muscle capillarization is a determining factor in gas and metabolite exchange, while its impairments may contribute to the development of sarcopenia. Studies on the potential of resistance training (RT) to induce angiogenesis in older muscles have been inconclusive, and effects of sequential endurance training (ET) and RT on capillarization are unknown. Healthy older men (66.5 ± 3.8 years) were engaged in either 12 weeks of habitual course observation (HC) followed by 12 weeks of RT (n = 8), or 12 weeks of high-intensity interval training (HIIT) followed by 12 weeks of RT (n = 9). At baseline, following 12 and 24 weeks, m. vastus lateralis biopsies were obtained. (Immuno-)histochemistry was used to assess indices of muscle fiber capillarization, muscle fiber morphology and succinate dehydrogenase (SDH) activity. Single periods of RT and HIIT resulted in similar improvements in capillarization and SDH activity. During RT following HIIT, improved capillarization and SDH activity, as well as muscle fiber morphology remained unchanged. The applied RT and HIIT protocols were thus similarly effective in enhancing capillarization and oxidative enzyme activity and RT effectively preserved HIIT-induced adaptations of these parameters. Hence, both, RT and HIIT, are valid training modalities for older men to improve skeletal muscle vascularization.
Visualizing the dynamic change of Ocular Response Analyzer waveform using Variational Autoencoder in association with the peripapillary retinal arteries angle
Authors: Asano Shotaro , Asaoka Ryo , Yamashita Takehiro , Aoki Shuichiro , Matsuura Masato , Fujino Yuri , Murata Hiroshi , Nakakura Shunsuke , Nakao Yoshitaka , Kiuchi Yoshiaki 
Published: April 2020

AbstractThe aim of the current study is to identify possible new Ocular Response Analyzer (ORA) waveform parameters related to changes of retinal structure/deformation, as measured by the peripapillary retinal arteries angle (PRAA), using a generative deep learning method of variational autoencoder (VAE). Fifty-four eyes of 52 subjects were enrolled. The PRAA was calculated from fundus photographs and was used to train a VAE model. By analyzing the ORA waveform reconstructed (noise filtered) using VAE, a novel ORA waveform parameter (Monot1-2), was introduced, representing the change in monotonicity between the first and second applanation peak of the waveform. The variables mostly related to the PRAA were identified from a set of 41 variables including age, axial length (AL), keratometry, ORA corneal hysteresis, ORA corneal resistant factor, 35 well established ORA waveform parameters, and Monot1-2, using a model selection method based on the second-order bias-corrected Akaike information criterion. The optimal model for PRAA was the AL and six ORA waveform parameters, including Monot1-2. This optimal model was significantly better than the model without Monot1-2 (p = 0.0031, ANOVA). The current study suggested the value of a generative deep learning approach in discovering new useful parameters that may have clinical relevance.
Transcriptome-wide shift from photosynthesis and energy metabolism upon endogenous fluid protein depletion in young Nepenthes ampullaria pitchers
Authors: Goh Hoe-Han , Baharin Anis , Mohd Salleh Faris ‘Imadi , Ravee Rishiesvari , Wan Zakaria Wan Nor Adibah , Mohd Noor Normah 
Published: April 2020

AbstractCarnivorous pitcher plants produce specialised pitcher organs containing secretory glands, which secrete acidic fluids with hydrolytic enzymes for prey digestion and nutrient absorption. The content of pitcher fluids has been the focus of many fluid protein profiling studies. These studies suggest an evolutionary convergence of a conserved group of similar enzymes in diverse families of pitcher plants. A recent study showed that endogenous proteins were replenished in the pitcher fluid, which indicates a feedback mechanism in protein secretion. This poses an interesting question on the physiological effect of plant protein loss. However, there is no study to date that describes the pitcher response to endogenous protein depletion. To address this gap of knowledge, we previously performed a comparative RNA-sequencing experiment of newly opened pitchers (D0) against pitchers after 3 days of opening (D3C) and pitchers with filtered endogenous proteins (>10 kDa) upon pitcher opening (D3L). Nepenthes ampullaria was chosen as a model study species due to their abundance and unique feeding behaviour on leaf litters. The analysis of unigenes with top 1% abundance found protein translation and stress response to be overrepresented in D0, compared to cell wall related, transport, and signalling for D3L. Differentially expressed gene (DEG) analysis identified DEGs with functional enrichment in protein regulation, secondary metabolism, intracellular trafficking, secretion, and vesicular transport. The transcriptomic landscape of the pitcher dramatically shifted towards intracellular transport and defence response at the expense of energy metabolism and photosynthesis upon endogenous protein depletion. This is supported by secretome, transportome, and transcription factor analysis with RT-qPCR validation based on independent samples. This study provides the first glimpse into the molecular responses of pitchers to protein loss with implications to future cost/benefit analysis of carnivorous pitcher plant energetics and resource allocation for adaptation in stochastic environments.
Laparoscopic Long Mesh Surgery with Augmented Round Ligaments: A Novel Uterine Preservation Procedure For Apical Pelvic Organ Prolapse
Authors: Long Cheng-Yu , Wang Chiu-Lin , Lin Kun-Ling , Ker Chin-Ru , Loo Zixi , Liu Yiyin , Wu Pei-Chi 
Published: April 2020

AbstractWe aim to assess the surgical outcomes of our novel hysteropexy procedure, laparoscopic long mesh surgery (LLMS) with augmented round ligaments. Twenty-five consecutive women with stage II or greater main uterine prolapse defined by the POP quantification staging system were referred for LLMS. Long mesh is a synthetic T-shaped mesh, with the body fixed at the uterine cervix and the two arms fixed along the bilateral round ligaments. The clinical evaluations performed before and 6 months after surgery included pelvic examinations, urodynamic studies, and questionnaires for urinary and sexual symptoms. After a follow-up time of 12 to 24 months, the anatomical reduction rate was 92% (23/25) for the apical compartment. The average operative time was 65.4  ±  28.8 minutes. No major complications were recognized during LLMS. The lower urinary tract symptoms and scores on the questionnaires improved significantly after the surgery, except urgency urinary incontinence and nocturia. Neither voiding nor storage dysfunction was observed after the operations. All of the domains and total Female Sexual Function Index (FSFI) scores of the 15 sexually active women did not differ significantly after LLMS. The results of our study suggest that LLMS is an effective, safe, and time-saving hysteropexy surgery for the treatment of apical prolapse.
Predicting miRNA-disease association from heterogeneous information network with GraRep embedding model
Authors: Ji Bo-Ya , You Zhu-Hong , Cheng Li , Zhou Ji-Ren , Alghazzawi Daniyal , Li Li-Ping 
Published: April 2020

AbstractIn recent years, accumulating evidences have shown that microRNA (miRNA) plays an important role in the exploration and treatment of diseases, so detection of the associations between miRNA and disease has been drawn more and more attentions. However, traditional experimental methods have the limitations of high cost and time- consuming, a computational method can help us more systematically and effectively predict the potential miRNA-disease associations. In this work, we proposed a novel network embedding-based heterogeneous information integration method to predict miRNA-disease associations. More specifically, a heterogeneous information network is constructed by combining the known associations among lncRNA, drug, protein, disease, and miRNA. After that, the network embedding method Learning Graph Representations with Global Structural Information (GraRep) is employed to learn embeddings of nodes in heterogeneous information network. In this way, the embedding representations of miRNA and disease are integrated with the attribute information of miRNA and disease (e.g. miRNA sequence information and disease semantic similarity) to represent miRNA-disease association pairs. Finally, the Random Forest (RF) classifier is used for predicting potential miRNA-disease associations. Under the 5-fold cross validation, our method obtained 85.11% prediction accuracy with 80.41% sensitivity at the AUC of 91.25%. In addition, in case studies of three major Human diseases, 45 (Colon Neoplasms), 42 (Breast Neoplasms) and 44 (Esophageal Neoplasms) of top-50 predicted miRNAs are respectively verified by other miRNA-disease association databases. In conclusion, the experimental results suggest that our method can be a powerful and useful tool for predicting potential miRNA-disease associations.
Virtual biopsy using MRI radiomics for prediction of BRAF status in melanoma brain metastasis
Authors: Shofty Ben , Artzi Moran , Shtrozberg Shai , Fanizzi Claudia , DiMeco Francesco , Haim Oz , Peleg Hason Shira , Ram Zvi , Bashat Dafna Ben , Grossman Rachel 
Published: April 2020

AbstractBrain metastases are common in patients with advanced melanoma and constitute a major cause of morbidity and mortality. Between 40% and 60% of melanomas harbor BRAF mutations. Selective BRAF inhibitor therapy has yielded improvement in clinical outcome; however, genetic discordance between the primary lesion and the metastatic tumor has been shown to occur. Currently, the only way to characterize the genetic landscape of a brain metastasis is by tissue sampling, which carries risks and potential complications. The aim of this study was to investigate the use of radiomics analysis for non-invasive identification of BRAF mutation in patients with melanoma brain metastases, based on conventional magnetic resonance imaging (MRI) data. We applied a machine-learning method, based on MRI radiomics features for noninvasive characterization of the BRAF status of brain metastases from melanoma (BMM) and applied it to BMM patients from two tertiary neuro-oncological centers. All patients underwent surgical resection for BMM, and their BRAF mutation status was determined as part of their oncological work-up. Their routine preoperative MRI study was used for radiomics-based analysis in which 195 features were extracted and classified according to their BRAF status via a support vector machine. The BRAF status of 53 study patients, with 54 brain metastases (25 positive, 29 negative for BRAF mutation) was predicted with mean accuracy = 0.79 ± 0.13, mean precision = 0.77 ± 0.14, mean sensitivity = 0.72 ± 0.20, mean specificity = 0.83 ± 0.11 and with a 0.78 area under the receiver operating characteristic curve for positive BRAF mutation prediction. Radiomics-based noninvasive genetic characterization is feasible and should be further verified using large prospective cohorts.
Dienedioic acid as a useful diene building block via directed Heck-decarboxylate coupling
Authors: Ke Lei , Chen Zhilong 
Published: April 2020

AbstractThe concise construction of diene scaffolds is quite useful in the synthesis of polyenes. Many diene building blocks have been developed based on Suzuki, Still and Hiyama couplings. Herein, the commercially available and environmentally friendly compound dienedioic acid is used as a diene building block. Broad substrate scope, good functional group tolerance, and late-stage derivatization of complex drug molecules are achieved. Different moieties can be conveniently introduced to both sides. Piperine and the methyl ester of azoxymycin C are each prepared in three steps. Additionally, one product shows promising anticancer activities in leukemia K562 and MV-4-11 cells. Mechanistic studies indicate that the reaction proceeds through a Heck-decarboxylate coupling procedure, and the carboxylic group acts as a directing group to promote the reaction and control regioselectivity. Our research suggests that dienedioic acid can serve as a good alternative for diene preparation via a directed Heck-decarboxylate coupling.
Importance of Cultural Competence in Supervisory Relationships
Authors: Subramanian Anu 
Published: April 2020

Purpose
The purpose of this article is to discuss the importance of cultural competence in the area of supervision. The article uses a fictional scenario to consider the value of open conversations about cultural experiences and differences to begin a supervisory relationship.

Conclusion
It is important for clinical educators to be aware of their cultural identity, gather knowledge about other cultures, and develop positive attitudes about different cultures. Clinical educators should use their supervisory meetings to initiate discussions related to cultural influences and differences to ensure supervisee success.
Diagnostik und Therapie von Schwerhörigkeit inkl. Cochlea-Implantat bei Migranten in Deutschland
Authors: Lesinski-Schiedat Anke , Lenarz Thomas , Illg Angelika 
Published: April 2020

ZusammenfassungDie medizinische Versorgung von Migranten – verantwortet von Ärzten – ist eine administrative und regulatorische Herausforderung. Klar verständliche gesetzliche Vorgaben und administrative Strukturen stehen zur Verfügung 1. Ärztlicherseits und in der allgemeinen Presse wird oft diskutiert, dass zu wenige Ärzte über die Therapie von Asylbewerbern entscheiden, sondern die Sachbearbeiter der Gesundheitsämter 2. In dem folgenden Beitrag werden diese Aspekte erfahrungsbasiert erläutert.
Kardiozirkulatorische Zwischenfälle während der
Schwangerschaft – eine prekäre Reanimationskonstellation
Authors: Strauss Alexander , Gräsner Jan-Thorsten 
Published: April 2020

ZusammenfassungKollaps und akuter Herz-Kreislauf-Stillstand (SCA) können Personen
beiderlei Geschlechts betreffen. Obwohl die Inzidenz eines SCA mit steigendem
Lebensalter positiv korreliert, können (selten) auch schwangere Frauen
von derartigen zirkulatorischen Notfällen betroffen sein. Passagere
Alterationen des mütterlichen Kreislaufs bei
Vena-cava-Kompressionssyndrom und Kollaps sind von einem vollständigen
Herz-Kreislauf-Stillstand variabler Genese zu unterscheiden. Jedes dieser
Einzelereignisse bedarf eines unmittelbaren, koordinierten,
multidisziplinären Notfallteameinsatzes. Nach situationsbedingter
Ersteinschätzung stehen zum Notfallmanagement unterschiedliche
algorithmische Handlungspfade zur Verfügung. Zeitnähe des
Beginns und Beachtung schwangerschaftsbedingter Besonderheiten der
Wiederbelebungsmaßnahmen bis hin zum perimortalen Notfallkaiserschnitt
entscheiden die mütterliche und in der Folge auch die fetale Prognose.
Zur spezialisierten Befähigung der Protagonisten sind
interdisziplinäre/interprofessionelle
Simulationstrainingseinheiten effektiv.
T-shaped Transseptal Approach for Mitral Valve Surgery
Authors: El Beyrouti Hazem , Kornberger Angela , Oberhoffer Martin , Vahl Christian-Friedrich 
Published: April 2020

AbstractWe present a T-shaped transseptal approach for mitral valve surgery that makes adequate exposure possible under challenging anatomic and surgical circumstances, hence eliminating the need for forceful retraction on potentially fragile tissues. Particularly suited for patients with complex mitral pathology, it also facilitates juxta-annular transseptal right atrial anchoring, especially in cases of endocarditic anterior mitral annular destruction.
Comparison of Inflammatory Markers like C - Reactive Protein, Total Leukocyte Count and Erythrocyte Sedimentation Rate in Type II Diabetes Mellitus
Authors: Mungamuri Aditya , Y. Sunil Kumar , N. Suchetha Kumari , Devi Ullal Harshini 
Published: April 2020

Abstract
Background: Diabetes Mellitus (DM) has become an epidemic in the 21st century where India leads the world with largest number of patients. There is increasing evidence that inflammation is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidaemia and atherosclerosis. Many previous studies indicate inflammatory markers like CRP, IL-6, IL-8, TNF-alpha, fibrinogen, total sialic acid, ceruloplasmin and total leucocyte count (TLC) are raised in Type II Diabetes Mellitus. However, not many studies have done association of ESR and TLC in DM.
Aims: In the present study inflammatory markers like CRP, total leukocyte count and ESR were compared in diabetic and non-diabetic patients.
Materials and Methods: 5mL of venous blood was taken from the study subjects.CRP, TLC and ESR was estimated.
Results: There was a significant rise in the CRP, TLC and ESR values seen in patients diagnosed with type II diabetes mellitus when compared to normal individuals. All three parameters (CRP, TLC, and ESR) were raised in a total of 7 cases (14%). 14 cases (28%) showed elevated levels of both CRP and ESR. A significant 8 cases (16%) showed elevation of CRP alone. There was a rise of ESR alone in 5 cases (10%).
Conclusion: CRP, TLC and ESR are elevated in diabetic patients in comparison to normal individuals. These increase the risk of diabetic related complications like atherosclerosis and dyslipaedemia. Hence, anti-inflammatory drugs in combination with antidiabetic treatment can delay these complications.
Oral Melanotic Macule – An Unusual Occurrence In Gingiva
Authors: R. Sajna H. , Thomas Biju , Ramesh Amitha , Bhandary Rahul , Kedlaya Madhurya N. 
Published: April 2020

AbstractMelanotic macule is the most common benign pigmented lesion of the oral cavity characterised by a focal increase in the melanin deposition. A 34 year old female patient reported with a chief complaint of black pigmentation with respect to maxillary gingiva between the central incisors since one year. An excisional biopsy was done for histo pathological examination, which revealed the lesion as melanotic macule.
Legionnaires Disease
Authors: R. Sandeep K. , S. Sandhya Rani B. 
Published: April 2020

AbstractLegionnaires' disease is a form of atypical pneumonia caused by any type of Legionella bacteria. The bacterium is found naturally in fresh water.[4] It can contaminate hot water tanks, hot tubs, and cooling towers of large air conditioners.[4] It is usually spread by breathing in mist that contains the bacteria.[4] It can also occur when contaminated water is aspirated.[4] It typically does not spread directly between people and most people who are exposed do not become infected.[4] Risk factors for infection include older age, history of smoking, chronic lung disease, and poor immune function.[5] There is still a low level of clinical awareness regarding Legionnaires' disease 25 years after it was first detected.
Arterial Blood Lactate in Children Primarily Submitted to Noninvasive Ventilation: A Time-Dependent ROC Analysis
Authors: Luz Luciana S. M. , Silva Andre Ricardo Araujo , Valete Cristina Ortiz Sobrinho 
Published: April 2020

AbstractThe purpose of this study was to evaluate blood lactate measurements and failure to noninvasive ventilation (NIV) in children admitted to a pediatric intensive care unit. This was a retrospective observational single-center study performed between June 2016 and June 2017. Dynamic lactate indices and failure to NIV in 63 children < 18 years and > 1 month old were examined; we considered blood lactate analyses at time 0, 6, 24, and 48 hours. NIV failure group had a higher pediatric risk of mortality (PRISM) score. Lactate indices decreased over time in the success group (p < 0.001). The best area under the curve observed was 69%, at 48 hours. Considering all measurements, the area under the curve for time-dependent receiver-operating characteristic curve was 58.6%. This study demonstrated blood lactate indices evolution over time in children submitted to NIV.
Analog synthesis of DAMASCENOLIDETM, an important aroma component of roses, and their odor properties
Authors: Miyazawa Yamato , Kawaguchi Kenji , Katsuta Ryo , Nukada Tomoo , Ishigami Ken 
Published: April 2020

Abstract
DAMASCENOLIDETM [1, 4-(4-methylpent-3-en-1-yl)furan-2(5H)-one], which has a citrus-like odor, is an important aroma component of roses. We have previously reported on the synthesis and odor evaluation of double-bond isomers of 1 and concluded that the position and the geometric isomerism of the double-bond had a significant effect on the odor. For the purpose of deepening knowledge about structure–odor relationships, we synthesized 13 analogs of compound 1 and evaluated their odors. As a result, it was found that the presence of two double-bonds and branched methyl group at the terminal position in the side chain was essential in order to have a citrus-like odor. Substitution of the side chain with appropriate length at the appropriate 4-position of the 2(5H)-furanone ring was also an important factor in determining the quality of the odor.
High-performance aramid fabric in infrared shielding by magnetron sputtering method
Authors: Jia Leilei , Fu Binhe , Lu Matthew Lee , Liang Hui-e , Wang Lei 
Published: April 2020

Abstract
In addition to providing basic protective functions, modern military uniforms are also being designed to provide special functions, such as infrared shielding. In this study, a nanoscale copper film was deposited on Kevlar para-1414 aramid fabric by magnetron sputtering technology to significantly enhance infrared shielding. The deposition of a uniform nano-copper film on the surface of the aramid fabric enhanced infrared shielding, tensile strain, and conductivity, which is of guiding significance for the development of infrared shielding garments.