bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between component-resolved diagnosis of house dust mite and efficacy of allergen immunotherapy in allergic rhinitis patients
Authors: Huang Yanran , Wang Chengshuo , Lin Xi , Lou Hongfei , Cao Feifei , Li Wenhan , Zhang Yuan , Zhang Luo 
Published: December 2019

AbstractData regarding clinical relevance of house dust mite (HDM) components over allergen immunotherapy (AIT) for allergic rhinitis (AR) are lacking. 18 adult AR patients receiving HDM-AIT for 52 weeks were followed up to assess serum levels of sIgE and sIgG4 to HDM components. The study showed that Der p1, p2, p23, Der f1 and f2, are important sensitizing components of HDM, of which Der p1 appears to be the most clinically relevant allergenic component for effective AIT.
Integrating spatial accessibility in the design of volcano evacuation plans in the French West Indies (Guadeloupe and Martinique)
Authors: Leone Frédéric , Komorowski Jean-Christophe , Gherardi-Leone Monique , Lalubie Guillaume 
Published: December 2019

AbstractThis article provides a spatial and comparative approach to evaluate the territorial accessibility in the event of a volcanic crisis in the French West Indies. A spatial assessment of resources and populations exposed to volcanic hazards is performed, followed by an assessment of the risk of territorial isolation due to lahars. Modelling of the risk of terrestrial isolation builds upon graph-based computations and indices that take into account the specific vulnerability of river-crossing structures and the knowledge of historical lahars. Another application of the graphs concerns scenarios for the evacuation of population, the sole efficient response to an eruption. This results in an optimised division of areas to evacuate in order to assess the potential reduction of the load on the road network. These different results are integrated into a prototype for evacuation maps intended for local authorities. The situation of Guadeloupe is of greater concern than that in Martinique, given the level of exposure, the potential losses of accessibility in case of lahars, and the greater and on-going volcanic unrest of La Soufrière volcano in Guadeloupe.
The subway microbiome: seasonal dynamics and direct comparison of air and surface bacterial communities
Authors: Gohli Jostein , Bøifot Kari Oline , Moen Line Victoria , Pastuszek Paulina , Skogan Gunnar , Udekwu Klas I. , Dybwad Marius 
Published: December 2019

Abstract
Background
Mass transit environments, such as subways, are uniquely important for transmission of microbes among humans and built environments, and for their ability to spread pathogens and impact large numbers of people. In order to gain a deeper understanding of microbiome dynamics in subways, we must identify variables that affect microbial composition and those microorganisms that are unique to specific habitats.

Methods
We performed high-throughput 16S rRNA gene sequencing of air and surface samples from 16 subway stations in Oslo, Norway, across all four seasons. Distinguishing features across seasons and between air and surface were identified using random forest classification analyses, followed by in-depth diversity analyses.

Results
There were significant differences between the air and surface bacterial communities, and across seasons. Highly abundant groups were generally ubiquitous; however, a large number of taxa with low prevalence and abundance were exclusively present in only one sample matrix or one season. Among the highly abundant families and genera, we found that some were uniquely so in air samples. In surface samples, all highly abundant groups were also well represented in air samples. This is congruent with a pattern observed for the entire dataset, namely that air samples had significantly higher within-sample diversity. We also observed a seasonal pattern: diversity was higher during spring and summer. Temperature had a strong effect on diversity in air but not on surface diversity. Among-sample diversity was also significantly associated with air/surface, season, and temperature.

Conclusions
The results presented here provide the first direct comparison of air and surface bacterial microbiomes, and the first assessment of seasonal variation in subways using culture-independent methods. While there were strong similarities between air and surface and across seasons, we found both diversity and the abundances of certain taxa to differ. This constitutes a significant step towards understanding the composition and dynamics of bacterial communities in subways, a highly important environment in our increasingly urbanized and interconnect world.
“Service with open arms”: enhancing community healthcare experiences for individuals with a history of incarceration
Authors: Walsh-Felz Devin , Westergaard Ryan , Waclawik Gabrielle , Pandhi Nancy 
Published: December 2019

Abstract
Background
The criminal justice-involved population has a higher disease burden than the general population and a high risk of death post-incarceration. However, this group underutilizes healthcare, especially preventive and primary care services. Sixteen in-person, semi-structured interviews were conducted with formerly incarcerated individuals in Milwaukee to explore health impacts of incarceration, barriers and facilitators to healthcare access, and what ideal health service provision would look like following incarceration. Interviews were transcribed, coded, and analyzed using an immersion/crystallization approach.

Results
Overall, people perceived incarceration to have a negative impact on their physical and mental health and expressed dissatisfaction with care in correctional settings. Many faced lapses in care following incarceration, frequently due to insurance challenges.

Conclusions
Participants offered advice for designing an ideal clinic including formal coordination with corrections and provision of additional social services. Staff demeanor that created a welcoming and caring environment was highlighted as an important component and facilitator of care.
Evaluation of the acute toxicity, phototoxicity and embryotoxicity of a residual aqueous fraction from extract of the Antarctic moss Sanionia uncinata
Authors: da Silva Fernandes Andréia , Brito Lara Barroso , Oliveira Gisele Augusto Rodrigues , Ferraz Elisa Raquel Anastácio , Evangelista Heitor , Mazzei José Luiz , Felzenszwalb Israel 
Published: December 2019

AbstractBackgroundUltraviolet (UV) radiation is the main exogenous inductor of skin damage and so photoprotection is important to control skin disorders. The Antarctic mossSanionia uncinatais an important source of antioxidants and the photoprotective activity of its organic extracts has been investigated. This study aimed to evaluate the potential photoprotection, cytotoxicity and embryotoxicity of residual aqueous fraction (AF) from the mossS. uncinata.MethodsUV-visible spectrum and SPF (sun protection factor) were determined by spectrophotometry. Embryotoxicity potential was evaluated by Fish embryo-larval toxicity test using zebrafish (Danio rerio) as organism model. Cell death assays by water-soluble tetrazolium salt (WST-1) and lactate dehydrogenase (LDH) were investigated using HaCaT keratinocyte cell line cultured in monolayers and three dimensions (3D). Phototoxicity and association with UV-filters were performed by 3T3 neutral red uptake test.ResultsThe AF showed sharp absorption bands in the UV region and less pronounced in the visible region. The SPF was low (2.5 ± 0.3), but the SPF values of benzophenone-3 and octyl-methoxycinnamate increased ~ 3 and 4 times more, respectively, in association with AF. The AF did not induce significant lethal and sublethal effects on zebrafish early-life stages. In monolayers, the HaCaT cell viability, evaluated by WST-1, was above 70% by ≤0.4 mg AF/mL after 48 and 72-h exposure, whereas ≤1 mg AF/mL after 24-h exposure. The LDH assay showed that the cell viability was above 70% by ≤0.4 mg AF/mL even after 72-h exposure, but ≤1 mg/mL after 24 and 48-h exposure. In 3D cell culture, an increased cell resistance to toxicity was observed, because cell viability of HaCaT cell by WST-1 and LDH was above ~ 90% when using ≤1 and 4 mg AF/mL, respectively. The AF demonstrated values of photo irritation factor < 2 and of photo effect < 0.1, even though in association with UV-filters.ConclusionsThe residual AF absorbs UV-vis spectrum, increased SPF values of BP-3 and OMC and does not induce embryotoxicity to zebrafish early life-stage. The cell death assays allowed establishing non-toxic doses of AF and phototoxicity was not detected. AF ofS. uncinatapresents a good potential for skin photoprotection against UV-radiation.
Assessing the significance of course materials for graduate program admission
Authors: Khaydarov Firdavs , Peterson Haley R. , Miller Carrie Lewis 
Published: December 2019

AbstractEnrollment into graduate programs continue to increase. Given major changes occurring within education (e.g., online courses and OER integration), it is imperative for faculty and students to be aware of the impact these changes could entail to those with higher education aspirations. The use of Open Educational Resources (OER) is one important change that has occurred with respect to the types of academic materials used in higher education courses. The use of OER has significantly expanded over the past decade. Resources accessible under the caption of OER are free and available in the public domain. Currently, there is little information regarding how these changes might affect graduate school applications or admission. The purpose of this study was to examine the importance of academic materials used in undergraduate classes in the evaluation of individuals for graduate admission. The results indicated that academic materials are the least important factor utilized for admission criteria. This result may indicate that the use of Open Educational Resources, low cost or free course materials with a copyright license that allows for reuse, should not impact the likelihood of a student being accepted into a graduate program.
The 2017 Nishinoshima eruption: combined analysis using Himawari-8 and multiple high-resolution satellite images
Authors: Kaneko Takayuki , Maeno Fukashi , Yasuda Atsushi , Takeo Minoru , Takasaki Kenji 
Published: December 2019

AbstractNishinoshima volcano suddenly resumed eruptive activity in April 2017 after about 1.5 years of dormancy since its previous activity in 2013–2015. Nishinoshima is an uninhabited isolated island. We analyzed the eruption sequence and the eruptive process of the 2017 eruption (17 April–10 August: 116 days) by combining high-temporal-resolution images from Himawari-8 and high-spatial-resolution images from the ALOS-2, Landsat-8, and Pleiades satellites. We used these data to discuss how temporal variations in the lava effusion rate affected the flow formations and topographical features of the effused lava. The total effused volume was estimated to be 1.6 × 107 m3, and the average effusion rate was 1.5 × 105 m3/day (1.7 m3/s). Based on variations in the thermal anomalies in the 1.6-μm band of Himawari-8, which roughly coincided with that of the lava effusion rate estimated by ALOS-2, the activity was segmented into five stages. In Stage 1 (17–30 April: 14 days), the lava effusion rate was the highest, and lava flowed to the west and southwest. Stage 2 (1 May–5 June: 36 days) showed a uniform decrease in flow, and lava flowed to the southwest and formed the southwestern lava delta. During Stage 3 (6–15 June: 10 days), the lava effusion rate increased in a pulsed manner, the flow direction changed from southwestward to westward, and a narrow lava flow effused from the southern slope of the cone. In Stage 4 (16 June–31 July: 46 days), the lava effusion rate decreased and lava flowed westward through lava tubes, enlarging the western lava delta. Around the end of July, lava effusion mostly stopped. Finally, in Stage 5 (1–10 August: 10 days), explosive eruptions occurred sporadically. The variation in lava effusion rate seemed to play an important role in forming different flow patterns of lava on Nishinoshima. In Stages 1 and 3, lava flowed in multiple directions, while in Stages 2 and 4, it flowed in single direction, probably because the effusion rate was lower. A pulsed increase in the lava effusion rate during Stage 3 caused new breaks and disturbances of the lava passages near the vents, which resulted in changes in flow directions. Differences in the size of lava lobes between the southwestern and western deltas are also considered to result from differences in the lava effusion rate.
Miniaturization effect of electroosmotic self-propulsive microswimmer powered by biofuel cell
Authors: Yamanaka Toshiro , Arai Fumihito 
Published: December 2019

AbstractFor future medical microrobotics, we have proposed the concept of the electroosmotic self-propulsive microswimmer powered by biofuel cell. According to the derived theoretical model, its self-propulsion velocity is inversely proportional to the length of the microswimmer, while it is proportional to the open circuit potential generated by the biofuel cell which does not depend on its size. Therefore, under conditions where those mechanisms work, it can be expected that the smaller its microswimmer size, the faster its self-propulsion velocity. Because of its remarkable feature, this concept is considered to be suitable as propulsion mechanisms for future medical microrobots to move inside the human body through the vascular system, including capillaries. We have already proved the mechanisms by observing the several 10 μm/s velocity of 100 μm prototypes fabricated by the optical photolithography using several photomasks and alignment steps. However, the standard photolithography was not suitable for further miniaturization of prototypes due to its insufficient resolution. In this research, we adopted femtosecond-laser 3D microlithography for multi-materials composing of the conductive polymer composites and nonconductive polymer composite and succeeded in fabricating 10 μm prototypes. Then we demonstrated more than 100 μm/s velocity of the prototype experimentally and proved its validity of the smaller and faster feature.
Effect of Different Physical Training Forms on Change of Direction Ability: a Systematic Review and Meta-analysis
Authors: Nygaard Falch Hallvard , Guldteig Rædergård Håvard , van den Tillaar Roland 
Published: December 2019

AbstractBackgroundThe ability to perform a rapid change of direction (COD) is a critical skill in numerous court- and field-based sports. The aim of this review is to investigate the effect of different physical training forms on COD performance.MethodsA systematic review of the literature was undertaken using the following databases: PubMed, SPORTDiscus and Google Scholar. Studies were eligible if they met the following criteria: (1) a COD test measuring performance before and after the training intervention, with specific description of the test in terms of length and number of changes in a direction with specified angles, (2) involve training intervention like plyometric, strength, sprint, specific COD training, or a combination of these training forms targeting the lower extremities, (3) the study had to state training background in terms of which sport they participated in and their competitive level and a detailed methodological description. Non-English articles were excluded. Percentage difference and effect sizes were calculated in order to compare the effects of different training interventions.ResultsA range of studies performing plyometrics, strength, sprint, specific COD training, training with post-activation potentiation or a combination of these training forms were examined. The percentage of change and effect size (ES) were calculated. Seventy-four studies met the inclusion criteria, comprising 132 experimental groups and 1652 unique subjects. The review revealed no clear consensus on which training form is optimal to develop COD performance. All training forms resulted in an increase in performance from almost no ES to large ES.ConclusionsThe results of the study indicate that COD ability is a specific skill, whereas the COD task, the sports require determines which training form is the most effective to develop COD ability. Training targeting improvement in COD performance should address the duration of the training in line with which energy system is utilized. The complexity of the COD task with respect to the individual athlete must be considered. Consequently, the number of changes in direction and the angles of the task are relevant when organizing training.
Results of the feasibility phase of the managed activity graded exercise in teenagers and pre-adolescents (MAGENTA) randomised controlled trial of treatments for chronic fatigue syndrome/myalgic encephalomyelitis
Authors: Brigden Amberly , Beasant Lucy , Gaunt Daisy , Hollingworth William , Mills Nicola , Solomon-Moore Emma , Jago Russell , Metcalfe Chris , Garfield Kirsty , Wray Charlotte , Trist Adam , Vilenchik Victoria , Grayson Caroline , Crawley Esther 
Published: December 2019

Abstract
Background
Chronic fatigue syndrome (CFS) also known as myalgic encephalomyelitis (ME) is relatively common in young people and causes significant disability. Graded exercise therapy (GET) and activity management are recommended by the National Institute for Health and Care Excellence (NICE) despite a limited evidence-base for either treatment in paediatric CFS/ME. This paper reports on feasibility and acceptability measures from the feasibility phase of the ongoing MAGENTA randomised controlled trial (RCT) investigating GET versus activity management for young people with CFS/ME.

Methods
Setting: Three specialist secondary care National Health Service (NHS) Paediatric CFS/ME services (Bath, Cambridge and Newcastle).
Participants: Young people aged 8–17 years with a diagnosis of mild to moderate CFS/ME. Young people were excluded if they were severely affected, referred to cognitive behavioural therapy (CBT) at initial assessment or unable to attend clinical sessions.
Interventions: GET and activity management delivered by physiotherapists, occupational therapists, nurses and psychologists. Families and clinicians decided the number (typically 8–12) and frequency of appointments (typically every 2–6 weeks).
Outcome Measures: Recruitment and follow-up statistics. We used integrated qualitative methodology to explore the feasibility and acceptability of the trial processes and the interventions.

Results
80/161 (49.7%) of eligible young people were recruited at two sites between September 2015 and August 2016, indicating recruitment to the trial was feasible. Most recruitment (78/80; 97.5%) took place at one centre. Recruitment consultations, online consent and interventions were acceptable, with less than 10% in each arm discontinuing trial treatment. Response rate to the primary outcome (the SF36-PFS at 6 months) was 91.4%. Recruitment, treatment and data collection were not feasible at one centre. The site was withdrawn from the study.
In response to data collected, we optimised trial processes including using Skype for recruitment discussions; adapting recruiter training to improve recruitment discussions; amending the accelerometer information leaflets; shortening the resource use questionnaires; and offering interventions via Skype. These amendments have been incorporated into the full trial protocol.

Conclusions
Conducting an RCT investigating GET versus activity management is feasible and acceptable for young people with CFS/ME.

Trial registration
ISRCTN23962803 10.1186/ISRCTN23962803, date of registration: 03 September 2015
Effect of households’ dietary knowledge on local (ofada) rice consumption in southwest Nigeria
Authors: Ogunleke A. O. , Baiyegunhi Lloyd J. S. 
Published: December 2019

AbstractAn understanding of dietary knowledge will most likely inform the consumption of healthy foods. Studies have shown that local (ofada) rice is superior to other rice brands in terms of protein and minerals crucial for overall mental and physical well-being. This study, therefore, examined the effect of households’ dietary knowledge on the consumption of local (ofada) rice, using a simultaneous equation system that accommodates censored dependent variable and continuous endogenous dietary knowledge. The study used survey data from 600 rice consumers’ households in southwest Nigeria and hypothesized that dietary knowledge affects the consumption of local (ofada) rice. The results revealed that dietary knowledge is significantly influenced by factors such as being a household meal planner and presence of household member(s) on a special diet. Dietary knowledge, as hypothesized, was found to positively influence the consumption of local (ofada) rice, as were some sociodemographic variables. The study recommends that effective dietary education about health and other benefits of consuming local (ofada) rice should be developed to promote its consumption in Nigerians’ diets.
GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement
Authors: Melvin Audrey , Chantzichristos Dimitrios , Kyle Catriona J , Mackenzie Scott D , Walker Brian R , Johannsson Gudmundur , Stimson Roland H , O’Rahilly Stephen 
Published: December 2019

Abstract

Context
GDF15 is a stress-induced hormone acting in the hindbrain that activates neural circuitry involved in establishing aversive responses and reducing food intake and body weight in animal models. Anorexia, weight loss, nausea and vomiting are common manifestations of glucocorticoid deficiency, and we hypothesized that glucocorticoid deficiency may be associated with elevated levels of GDF15.

Objective
To determine the impact of primary adrenal insufficiency (PAI) and glucocorticoid replacement on circulating GDF15 levels.

Methods and Results
We measured circulating concentrations of GDF15 in a cohort of healthy volunteers and Addison’s disease patients following steroid withdrawal. Significantly higher GDF15 (mean ± standard deviation [SD]) was observed in the Addison’s cohort, 739.1 ± 225.8 pg/mL compared to healthy controls, 497.9 ± 167.7 pg/mL (P = 0.01). The effect of hydrocortisone replacement on GDF15 was assessed in 3 independent PAI cohorts with classical congenital adrenal hyperplasia or Addison’s disease; intravenous hydrocortisone replacement reduced GDF15 in all groups. We examined the response of GDF15 to increasing doses of glucocorticoid replacement in healthy volunteers with pharmacologically mediated cortisol deficiency. A dose-dependent difference in GDF15 (mean ± SD) was observed between the groups with values of 491.0 ± 157.7 pg/mL, 427.0 ± 152.1 pg/mL and 360 ± 143.1 pg/mL, in the low, medium and high glucocorticoid replacement groups, respectively, P &lt; .0001.

Conclusions
GDF15 is increased in states of glucocorticoid deficiency and restored by glucocorticoid replacement. Given the site of action of GDF15 in the hindbrain and its effects on appetite, further study is required to determine the effect of GDF15 in mediating the anorexia and nausea that is a common feature of glucocorticoid deficiency.