bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a Small Amount of Thermoplastic Starch Blend on the Mechanical Recycling of Conventional Plastics
Authors: Åkesson Dan , Kuzhanthaivelu Gauthaman , Bohlén Martin 
Published: October 2020

AbstractThe usage of bioplastics could increase in the future which may cause contamination of the waste streams of conventional plastics. The objective of this study was to investigate if a small amount of biopolymer contaminating conventional polymers would significantly affect mechanical and thermal properties. A starch-based plastic was first compounded by blending plasticised starch with PLA (polylactic acid). This polymer blend was subsequently compounded with HDPE (high density polyethylene), PP (polypropylene) or PET (polyethylene terephthalate) at 0%, 1% and 5% of the biopolymer. The compounds were characterised by tensile tests, Charpy impact tests, DSC (differential scanning calorimetry) and FESEM (field emission scanning electron microscopy). Tests showed that PE and PP were not significantly affected in terms of tensile strength and modulus but the elongation at break showed a strong reduction. PET was, on the other hand, incompatible with the starch-based plastic. Already at 1% contamination, PET had lost most of its impact strength.
Complex Formation Between Zinc(II) and Alkyl-N-iminodiacetic Acids in Aqueous Solution and Solid State
Authors: Häggman Leif , Lindblad Cecilia , Cassel Anders , Persson Ingmar 
Published: October 2020

AbstractRemoval of metal compounds from wastewater using processes where metals can be removed and valuable chemicals recycled is of significant industrial importance. Chelating surfactants are an interesting group of chemicals to be used in such applications. Carboxylated polyamines are a promising group to be used in such processes. To apply carboxylated polyamines as chelating surfactants, detailed knowledge of the solution chemistry, including complex formation, kinetics and structures of pure fundamental systems, is required. In this study zinc(II) alkyl-N-iminodiacetate systems with varying length of the alkyl chain have been studied. Acidic and stability constants have been studied by potentiometry, and the structures of both solids and aqueous solutions have been determined by EXAFS. Zinc(II) forms two strong complexes with alkyl-N-iminodiacetates in aqueous solution. In an attempt to determine the acidic constants of these complexes, the deprotonation of the nitrogen atom in the complex bound ligands, it was observed that this reaction is very slow and no accurate values could be obtained. The bis(alkyl-N-iminodiacetato)zincate(II) complexes take, however, up two protons in the pH region 3–7, which means that this complex is approximately singly protonated in the pH region 3–7 and doubly protonated at pH < 3. The bis(n-hexyl-N-iminodiacetato)zincate(II) complex at pH = 13 has a distorted octahedral configuration with four short strong Zn–O bonds at 2.08(1) Å, while the Zn–N bonds are weaker at much longer distance, 2.28(2) Å. Similar configurations are also found in most reported structures of zinc(II) complexes with carboxylated amines/polyamines. The singly protonated complex seems to be five-coordinate, with four Zn–O bond distances at ca. 2.03 Å, and a single Zn–N bond distance in the range 2.15–2.25 Å. The relationship between the structure of the protonated bis(n-hexyl-N-iminodiacetato)zincate(II) complex and the slow kinetics in the region pH = 3–7 are discussed.
Population dynamics and natural hazard risk management: conceptual and practical linkages for the case of Austrian policy making
Authors: Clar Christoph , Löschner Lukas , Nordbeck Ralf , Fischer Tatjana , Thaler Thomas 
Published: October 2020

AbstractThis contribution explores the conceptual and empirical linkages between population dynamics and natural hazard risk management (NHRM). Following a review of the international scholarly literature, we conduct a mixed-methods approach in Austria, combining an online survey among policy makers and other stakeholders with a thematic analysis of policy documents. The aim is to investigate the practical relevance of socio-demographic change in Austria’s NHRM. The study shows that many hazard-prone regions in Austria face population change, in particular demographic ageing and population decline. In addition, our findings from the online survey demonstrate the relevance of population dynamics in NHRM, especially with regard to hazard response and recovery. Nonetheless, policy formulation in NHRM overwhelmingly disregards demographic change as a relevant factor. Accordingly, the study underscores the importance of future-oriented risk management strategies to better account for ongoing and expected socio-demographic changes.
Interactive editing of virtual chordae tendineae for the simulation of the mitral valve in a decision support system
Authors: Walczak Lars , Tautz Lennart , Neugebauer Mathias , Georgii Joachim , Wamala Isaac , Sündermann Simon , Falk Volkmar , Hennemuth Anja 
Published: October 2020

Abstract
Purpose
Decision support systems for mitral valve disease are an important step toward personalized surgery planning. A simulation of the mitral valve apparatus is required for decision support. Building a model of the chordae tendineae is an essential component of a mitral valve simulation. Due to image quality and artifacts, the chordae tendineae cannot be reliably detected in medical imaging.

Methods
Using the position-based dynamics framework, we are able to realistically simulate the opening and closing of the mitral valve. Here, we present a heuristic method for building an initial chordae model needed for a successful simulation. In addition to the heuristic, we present an interactive editor to refine the chordae model and to further improve pathology reproduction as well as geometric approximation of the closed valve.

Results
For evaluation, five mitral valves were reconstructed based on image sequences of patients scheduled for mitral valve surgery. We evaluated the approximation of the closed valves using either just the heuristic chordae model or a manually refined model. Using the manually refined models, prolapse was correctly reproduced in four of the five cases compared to two of the five cases when using the heuristic. In addition, using the editor improved the approximation in four cases.

Conclusions
Our approach is suitable to create realistically parameterized mitral valve apparatus reconstructions for the simulation of normally and abnormally closing valves in a decision support system.
Valuation of firms with multiple business units
Authors: Dierkes Stefan , Schäfer Ulrich 
Published: October 2020

AbstractCorporate valuation often relies on the assumption of a constant and homogenous growth rate. However, large firms frequently (re)balance their activities by diverting cash flows from some business units to fund investments in other units. We develop a value driver model of terminal value for a firm with two units. The model relaxes common assumptions and allows for cross-unit differences in the return on invested capital. We consider intra-unit and cross-unit investments and show their implications for firm value and the long-term development of key accounting variables. Our results help characterize business unit strategies that can be reconciled with popular firm strategies such as the constant payout and constant growth strategies. We find that popular valuation methods that assume both constant payout ratios and constant growth rates (e.g., Gordon and Shapiro, Manage Sci 3:102–110, 1956) constitute a restrictive special case of our model and should only be applied to firms with homogenous business units. We use a simulation analysis to compare our results with alternative valuation models and to illustrate the economic relevance of our findings. The simulation shows that an accurate depiction of business unit strategy is particularly useful if firms plan large-scale cross-unit investments into business units with high returns and if the cost of capital is low.
Participatory multi-modelling as the creation of a boundary object ecology: the case of future energy infrastructures in the Rotterdam Port Industrial Cluster
Authors: Cuppen Eefje , Nikolic Igor , Kwakkel Jan , Quist Jaco 
Published: October 2020

AbstractFinding leverage points for sustainability transformation of industrial and infrastructure systems is challenging, given that transformation is emergent from the complex interactions among socio-technical system elements over time within a specific social, technical and geographical context. Participatory multi-modelling, in which modellers and stakeholders collaborate to develop multiple interacting models to support a shared understanding of systems, is a promising approach to support sustainability transformations. Theparticipatory processof modeling can serve as a leverage point by facilitating social learning amongst stakeholders, in which models can function as boundary objects that facilitate dialogue between stakeholders from different social worlds. We propose that participatory multi-modeling allows for the creation ofa boundary object ecology, which involves a set of interacting and co-evolving boundary objects emerging throughout the modeling process. To explore this, we analyse the participatory multi-modelling process in the Windmaster project in the Rotterdam Port industrial cluster to understand which design choices were key to the creation of boundary objects. Our analysis shows that two types of design choices were key: design choices that enabled translations between participants, and those between participants and their organisation. We conclude that conceptualising participatory multi-modelling as a process of an evolving boundary object ecology, creating and adaptingmultipleinteracting boundary objects provides a novel perspective that is useful for analysis and design of future participatory multi-modeling processes.
A NURBS-based solid modeling to enhance rapid prototyping in the restoration of decorative elements
Authors: Calì Michele , Oliveri Salvatore Massimo , Calì Placido , Ambu Rita 
Published: October 2020

AbstractIn this research, we describe a computer-aided approach to improve the reconstruction method of decorum in architectural surfaces and sculpture. The effects of withdrawal caused by catalysis of mold in silicone was evaluated and simulated by a NURBS-based solid modelling. A tolerance analysis model was developed to predict manufacturing precision levels. In particular, differential increment along three dimensions was performed considering different volume distributions. The methodology was validated by experimental data obtained during the coffered ceiling restoration of Teatro Massimo Vittorio Emanuele in Palermo. The proposed methodology allowed the reconstruction of decorations or fragments of decoration with high accuracy.
Protective Role of Low Ethanol Administration Following Ischemic Stroke via Recovery of KCC2 and p75NTR Expression
Authors: Khirug Stanislav , Soni Shetal , Saez Garcia Marta , Tessier Marine , Zhou Liang , Kulesskaya Natalia , Rauvala Heikki , Lindholm Dan , Ludwig Anastasia , Molinari Florence , Rivera Claudio 
Published: October 2020

AbstractA striking result from epidemiological studies show a correlation between low alcohol intake and lower incidence for ischemic stroke and severity of derived brain injury. Although reduced apoptosis and inflammation has been suggested to be involved, little is known about the mechanism mediating this effect in vivo. Increase in intracellular chloride concentration and derived depolarizing GABAAR-mediated transmission are common consequences following various brain injuries and are caused by the abnormal expression levels of the chloride cotransporters NKCC1 and KCC2. Downstream pro-apoptotic signaling through p75NTR may link GABAA depolarization with post-injury neuronal apoptosis. Here, we show that changes in GABAergic signaling, Cl− homeostasis, and expression of chloride cotransporters in the post-traumatic mouse brain can be significantly reduced by administration of 3% ethanol to the drinking water. Ethanol-induced upregulation of KCC2 has a positive impact on neuronal survival, preserving a large part of the cortical peri-infarct zone, as well as preventing the massive post-ischemic upregulation of the pro-apoptotic protein p75NTR. Importantly, intracortical multisite in vivo recordings showed that ethanol treatment could significantly ameliorate stroke-induced reduction in cortical activity. This surprising finding discloses a pathway triggered by low concentration of ethanol as a novel therapeutically relevant target.
Immunosuppressive regimens for adult liver transplant recipients in real-life practice: consensus recommendations from an Italian Working Group
Authors: Cillo Umberto , De Carlis Luciano , Del Gaudio Massimo , De Simone Paolo , Fagiuoli Stefano , Lupo Francesco , Tisone Giuseppe , Volpes Riccardo 
Published: October 2020

AbstractIt is a well-recognized fact that implementing new guidelines in clinical practice may be difficult; therefore the Italian Society for Organ and Tissue Transplantation (SITO) set out to define practical immunosuppression tools for the management of liver transplantation patients. In 2017, an Italian Working Group of liver transplant experts and hepatologists issued a set of consensus statements along with evidence-based recommendations on the use of everolimus after liver transplantation. This article presents the evidence- and consensus-based algorithms developed within the Italian Working Group, which are aimed towards guiding clinicians in the selection of immunosuppressive regimens for the management of adult liver transplant recipients in real-life practice. The liver transplant recipient population, typically managed in clinical practice, was divided into the following categories: (1) standard patients; (2) critically ill patients; (3) patients with a specific etiology; (4) patients with hepatocellular carcinoma; (5) and patients with de novo malignancies. The algorithms are divided into two parts, according to the time from transplantation (0–3 months and > 3 months) and are discussed here along with relevant supporting literature, when available. Ultimately, it is hoped that the evidence- and consensus-based algorithms developed within the Italian Working Group, and presented here, contribute to simplify, personalize, and optimize immunosuppression of liver transplantation recipients in clinical practice.
Ropeginterferon alfa-2b every 2 weeks as a novel pegylated interferon for patients with chronic hepatitis B
Authors: Huang Yi-Wen , Hsu Chao-Wei , Lu Sheng-Nan , Yu Ming-Lung , Su Chien-Wei , Su Wei-Wen , Chien Rong-Nan , Hsu Ching-Sheng , Hsu Shih-Jer , Lai Hsueh-Chou , Qin Albert , Tseng Kuan-Chiao , Chen Pei-Jer 
Published: October 2020

Abstract
Background
Ropeginterferon alfa-2b is a novel mono-pegylated interferon that has only one major form as opposed to 8–14 isomers of other on-market pegylated interferon, allowing injection every two or more weeks with higher tolerability. It received European Medicines Agency and Taiwan marketing authorization in 2019 and 2020, for treatment of polycythemia vera. This phase I/II study aimed to have preliminary evaluation of safety and efficacy in chronic hepatitis B.

Methods
Thirty-one HBeAg-positive and 31 HBeAg-negative were stratified by HBeAg status and randomized at 1:1:1 ratio to q2w ropeginterferon alfa-2b 350 μg (group 1), q2w 450 μg (group 2) or q1w PEG-IFN alfa-2a 180 μg (group 3). Each patient received 48-week treatment (TW48) and 24-week post-treatment follow-up (FW24).

Results
The baseline demographics were comparable among the three groups, except for mean HBeAg in HBeAg-positive patients (2.90, 2.23, 2.99 log10 S/CO, respectively). Cumulative HBeAg seroconversion rate at follow-up period was 27.3% (3/11), 36.4% (4/11), and 11.1% (1/9) with time to HBeAg seroconversion starting from TW24, TW16, and TW48 in group 1, 2, and 3, respectively. The rate of HBV DNA < 2000 IU/mL and HBsAg levels < 1500 IU/mL at FW24 were comparable in all groups. Ropeginterferon alfa-2b (group 1 & 2) had numerically lower incidence of rash (9.5% and 4.5%) as compared to PEG-IFN alfa-2a (36.8%). Ropeginterferon alfa-2b 350 μg (group 1) had more ALT elevation (38.1%), however the rate was comparable in group 2 (9.1%) and group 3 (10.5%).

Conclusion
In this preliminary study, ropeginterferon alfa-2b, although in only half the number of injections, is as safe and effective as pegylated interferon alfa-2a for chronic hepatitis B.

Graphic abstract
Environmental-Economic Assessment of the Pressure Swing Adsorption Biogas Upgrading Technology
Authors: Kohlheb Norbert , Wluka Mathias , Bezama Alberto , Thrän Daniela , Aurich Andreas , Müller Roland Arno 
Published: October 2020

AbstractA large-scale biogas upgrading plant using the CarboTech® technology with a treatment capacity of 1333 Nm3 biogas per hour was analyzed. Our scope of evaluation encompasses all technology steps that are necessary for upgrading biogas, i.e., both pretreatment and biogas upgrade. A cradle-to-gate life-cycle and life-cycle cost assessment (LCA and LCCA) methodology was used with the functional unit (FU) of 1 Nm3 of biogas upgraded in order to ease comparison with other biogas upgrading technologies. The calculation was made using the GaBi8 LCA software and databases of GaBi Professional, Construction materials, Food&Feed, and the ecoinvent3. We applied the CML characterization model with all its mid-point indicators. The mid-point indicators of the CML characterization model were aggregated after normalization by the CML2001 - Jan.2016 normalization factors. The normalized environmental impact was 541.74·10−15/Nm3 raw biogas. The highest environmental impacts were the marine aquatic ecotoxicity potential (15.705 kg dichlorobenzene-equiv./Nm3 raw biogas), the abiotic depletion potential (1.037 MJ/Nm3 raw biogas), and global warming potential (0.113 kg CO2-equiv./Nm3 raw biogas). The unit production cost of the PSA technology was 0.05-0.063 €/Nm3 raw biogas. The most considerable source of expenses was the operational cost from which 77% was spent on electricity. The initial investment, personal costs, and the reinvestment amounted to only 34% of the total costs for the whole life cycle. Strategies to lower the environmental burden of the PSA technology are to use green electricity and to optimize the size of the plant in order to reduce unnecessary material flows of building material and their indirect energy use. This can also lower investment expenditures while automatization and remote control may spare personnel costs.
Effect of a yeast autolysate produced by high pressure homogenization on white wine evolution during ageing
Authors: Voce Sabrina , Calligaris Sonia , Comuzzo Piergiorgio 
Published: October 2020

AbstractThe enological characteristics and the performances of a yeast autolysate produced by high pressure homogenization (HPH-YD) were investigated for the first time in white wine and model solution, in comparison with a thermolysate (T-YD) and a commercial yeast derivative (COMM). In wine-like medium, HPH-YD showed a significant release of glucidic colloids (on average, slightly higher than the other products), also leading to a greater glutathione solubilization with respect to T-YD. Concerning the volatile composition of the autolysates, HPH-YD was characterized by the highest concentration of alcohols and esters, while showing an average amount of fatty acids, carbonyls and heterocyclic compounds lower than COMM. These features are potentially linked to a more favorable impact of this product on the composition of wine aroma, should these compounds be released into the wine itself. HPH-YD determined minor modifications on wine volatile profile when added for short contact times, without releasing unwanted compounds and with a slightly lower binding capacity towards wine esters. The effects of the three yeast derivatives (YDs) on wine color during ageing was also investigated in comparison with sulfur dioxide (SO2). HPH-YD was the most efficient preparation, limiting wine color changes due to oxidation during four months and behaving more similarly to SO2. The use of HPH for the production of yeast autolysates for winemaking may represent an interesting alternative to thermal treatments, improving the enological characteristics of these additives, particularly their antioxidant capacity, leading anyhow a significant release of colloidal molecules and a limited impact on wine aroma composition.
miR-224 targets BTRC and promotes cell migration and invasion in colorectal cancer
Authors: Zheng Qi , Yu Jane J. , Li Chenggang , Li Jiali , Wang Jiping , Wang Shuyang 
Published: October 2020

AbstractOur study aims to investigate the impact of miR-224 on cell migration and invasion in colorectal cancer (CRC) as well as its molecular mechanisms. The results showed that miR-224 was significantly upregulated in CRC compared to normal tissues via the TCGA database. Overexpression of miR-224 promoted CRC cell migration and invasion, while inhibition of miR-224 demonstrated the opposite result via transwell assays. In addition, we found that BTRC was a target gene of miR-224 through the miRecords database and dual-luciferase assay, while western blot together with RT-qPCR showed that inhibition of miR-224 led to elevated BTRC expression in protein level but not in mRNA level, and also decreased the expression of β-catenin. In reference to the Human Protein Atlas, BTRC protein expression was higher in normal tissues than in CRC tissues. In conclusion, miR-224 regulates its target BTRC protein expression and its related Wnt/β-catenin pathway. Its impact on cell migration and invasion in CRC cells suggested that miR-224 could be a prospective therapeutic target for early-stage non-metastatic CRC.
Older age groups and country-specific case fatality rates of COVID-19 in Europe, USA and Canada
Authors: Hoffmann Christian , Wolf Eva 
Published: October 2020

AbstractPurposeTo evaluate the association between the percentages of older age groups among confirmed SARS-CoV-2 infections and the country-specific case fatality rate (CFR).MethodsThis ecological study analyzed data from the 20 most severely affected European countries, USA and Canada, in which national health authorities provided data on age distribution and gender among confirmed SARS-CoV-2 cases and deaths.ResultsThe proportion of individuals older than 70 years among confirmed SARS-CoV-2 cases differed markedly between the countries, ranging from 4.9 to 40.4%. There was a strong linear association between the proportion of individuals older than 75 years and the country-specific CFRs (R2 = 0.803 for all countries,R2 = 0.961 after exclusion of three countries with incongruent data). Each 5% point increase of this older age group among confirmed SARS-CoV-2 cases was associated with an increase in CFR of 2.5% points (95% CI 1.9–3.1).ConclusionData from 20 European countries and the USA and Canada showed that the variance of crude CFR of COVID-19 is predominantly (80–96%) determined by the proportion of older individuals who are diagnosed with SARS-CoV-2. The age distribution of SARS-CoV-2 infections is still far from being homogeneous. Detailed demographic data have to be taken into account in all the analyses on COVID-19-associated mortality. We urgently call for standardized data collection by national health authorities.