bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-performance liquid chromatographic profile and 1H quantitative nuclear magnetic resonance analyses for quality control of a Xinjiang licorice extract
Authors: Miyazaki Atsumi , Eerdunbayaer  , Shiokawa Tsugumi , Tada Hiroko , Lian Yunhe , Taniguchi Shoko , Hatano Tsutomu 
Published: July 2020

Abstract
Various pharmacological properties of Xinjiang licorice flavonoids have been reported recently. We have investigated constituents corresponding to distinct peaks on the high-performance liquid chromatography (HPLC) profile of a flavonoid-rich extract from licorice, and identified 13 flavonoids, including licochalcone A (1), licochalcone B (3), glabrone (4), and echinatin (5), by isolating them and then performing high-resolution electrospray ionization mass spectrometry and 1H nuclear magnetic resonance (NMR) spectral analyses. We then applied the 1H quantitative NMR (qNMR) method for analysis of major flavonoids, 1 and 3–5 in the extract. The 1H qNMR results were supported by 13C NMR analysis. The results demonstrated the utility of the combination of HPLC profiling and qNMR analyses for quality control of Xinjiang licorice. Additionally, we observed a moderate inhibitory effect of the most abundant constituent, licochalcone A (1), on acetylcholine esterase activity, suggesting utility as a seed for drug development.
The RNA‐binding protein hnRNPU regulates the sorting of microRNA‐30c‐5p into large extracellular vesicles
Authors: Zietzer Andreas , Hosen Mohammed Rabiul , Wang Han , Goody Philip Roger , Sylvester Marc , Latz Eicke , Nickenig Georg , Werner Nikos , Jansen Felix 
Published: July 2020

ABSTRACTThe transfer of microRNAs (miRs) via extracellular vesicles (EVs) is a functionally relevant mechanism of intercellular communication that regulates both organ homoeostasis and disease development. Little is known about the packaging of miRs into EVs. Previous studies have shown that certain miRs are exported by RNA‐binding proteins into small EVs, while for other miRs and for large EVs, in general, the export mechanisms remain unclear. Therefore, a proteomic analysis of endothelial cell‐derived large EVs was performed, which revealed that heterogeneous nuclear ribonucleoprotein U (hnRNPU) is abundantly present in EVs. EVs were characterized by electron microscopy, immunoblotting and nanoparticle tracking analysis. Taqman microRNA array and single qPCR experiments identified specific miR patterns to be exported into EVs in an hnRNPU‐dependent way. The specific role of hnRNPU for vesicular miR‐sorting was confirmed independently by gain‐ and loss‐of‐function experiments. In our study, miR‐30c‐5p was the miR whose export was most significantly regulated by hnRNPU. Mechanistically, in silico binding analysis showed that the export of miRs into EVs depends on the binding efficiency of the respective miRs to hnRNPU. Among the exported miRs, a significant enrichment of the sequence motif AAMRUGCU was detected as a potential sorting signal. Experimentally, binding of miR‐30c‐5p to hnRNPU was confirmed independently by RNA‐immunoprecipitation, electrophoretic mobility shift assay and reciprocally by miR‐pulldown. Nuclear binding of miR‐30c‐5p to hnRNPU and subsequent stabilization was associated with a lower cytoplasmatic abundance and consequently reduced availability for vesicular export. hnRNPU‐dependent miR‐30c‐5p export reduced cellular migration as well as pro‐angiogenic gene expression in EV‐recipient cells. In summary, hnRNPU retains miR‐30c‐5p and other miRs and thereby prevents their export into large EVs. The data presented provide a novel and functionally relevant mechanism of vesicular miR export.
Probing string-inspired gravity with the inspiral–merger–ringdown consistency tests of gravitational waves
Authors: Carson Zack , Yagi Kent 
Published: July 2020

Abstract
The extreme-gravity collisions between black holes allow us to probe the underlying theory of gravity. We apply a predictive forecast of the theory-agnostic inspiral–merger–ringdown consistency test to an example theory beyond general relativity for the first time, for future gravitational wave observations. Here we focus on the string-inspired Einstein-dilaton Gauss–Bonnet gravity and modify the inspiral, ringdown, and remnant black hole properties of the gravitational waveform. We found that future multiband observations allow us to constrain the theory stronger than current observations by an order of magnitude. The formalism developed here can easily be applied to other theories.
A kinetic model of continuous radiation damage to populations of cells: comparison to the LQ model and application to molecular radiotherapy
Authors: Neira Sara , Gago-Arias Araceli , Guiu-Souto Jacobo , Pardo-Montero Juan 
Published: July 2020

Abstract
The linear-quadratic (LQ) model to describe the survival of irradiated cells may be the most frequently used biomathematical model in radiotherapy. There has been an intense debate on the mechanistic origin of the LQ model. An interesting approach is that of obtaining LQ-like behavior from kinetic models, systems of differential equations that model the induction and repair of damage. Development of such kinetic models is particularly interesting for application to continuous dose rate therapies, such as molecular radiotherapy or brachytherapy. In this work, we present a simple kinetic model that describes the kinetics of populations of tumor cells, rather than lethal/sub-lethal lesions, which may be especially useful for application to continuous dose rate therapies, as in molecular radiotherapy. The multi-compartment model consists of a set of three differential equations. The model incorporates in an easy way different cross-interacting compartments of cells forming a tumor, and may be of especial interest for studying dynamics of treated tumors. In the fast dose delivery limit, the model can be analytically solved, obtaining a simple closed-form expression. Fitting of several surviving curves with both this solution and the LQ model shows that they produce similar fits, despite being functionally different. We have also investigated the operation of the model in the continuous dose rate scenario, firstly by fitting pre-clinical data of tumor response to 131I-CLR1404 therapy, and secondly by showing how damage repair and proliferation rates can cause a treatment to achieve control or not. Kinetic models like the one presented in this work may be of special interest when modeling response to molecular radiotherapy.
Traveling fronts in self-replicating persistent random walks with multiple internal states
Authors: Ishihara Keisuke , George Ashish B , Cornelius Ryan , Korolev Kirill S 
Published: July 2020

Abstract
Self-activation coupled to a transport mechanism results in traveling waves that describe polymerization reactions, forest fires, tumor growth, and even the spread of epidemics. Diffusion is a simple and commonly used model of particle transport. Many physical and biological systems are, however, better described by persistent random walks that switch between multiple states of ballistic motion. So far, traveling fronts in persistent random walk models have only been analyzed in special, simplified cases. Here, we formulate the general model of reaction-transport processes in such systems and show how to compute the expansion velocity for arbitrary number of states. For the two-state model, we obtain a closed-form expression for the velocity and report how it is affected by different transport and replication parameters. We also show that nonzero death rates result in a discontinuous transition from quiescence to propagation. We compare our results to a recent observation of a discontinuous onset of propagation in microtubule asters and comment on the universal nature of the underlying mechanism.
Compaction of dispersed granular material by a vibratory compactor with polyharmonic oscillation exciter
Authors: Morozov AV , Usoltsev VM 
Published: July 2020

Abstract
This paper addresses problems connected with machine engineering for compaction of powder materials by vibration. The authors present an engineering solution of disperse granular material compaction in pone operating cycle of a compacting equipment. The structural layout of a vibratory compactor involves a polyharmonic oscillation exciter. Some research findings on the compaction process of granular material with the proposed facility are given, and its efficiency is compared with a compacter with a harmonic oscillation exciter. The research shows the promising nature of this method, while the polyharmonic oscillation exciter expands the application range of vibratory equipment in many industries.
Geomechanical justification of geotechnical situation in coal extraction with highwall mining system
Authors: Neverov AA , Nikolsky AM , Tsymbalyuk TA 
Published: July 2020

Abstract
One of the most effective approaches to reduction of coal loss in open pit within ultimate limits is extraction of coal reserves from the pit walls and bottom using the highwall mining systems. The high efficiency of the method is conditioned by minimal capital cost and reuse of the existing geotechnical infrastructure. On the other hand, the safe application of this approach depends on the rock mass quality. In mining practice, the major application area of the highwall mining systems is pitwall rock mass of damping jointing. In this connection, this paper aims to estimate influence of rock mass quality on stability of pit wall and underground openings (rooms and pillars). The set problem is solved by the finite element modeling of geomechanical situation for standard conditions of an open pit coal mine. The novelty of the research consists in more comprehensive inclusion of rock mass lithology, jointing, deformation and strength characteristics, initial stress state and structural features of technology in the problem solution.
Validation of variants and structural parameters for mining systems for thin ore bodies
Authors: Shchukin SA , Konurin AI , Neverov SA 
Published: July 2020

Abstract
The current mining of thin and steeply dipping ore bodies features depth down to 700–1100 m below ground surface, increased dimension of various-purpose pillars and, as consequence, higher mineral loss and overall degradation of mining efficiency. In connection with this, it is urgent to find new mining systems as well as scientific approaches to validation of safe parameters of geotechnologies such that, depending on geological and geomechanical conditions, as well as on mineral value, minimize geotechnical risks and maintain competitiveness of production. The aim of this study is to determine safe parameters of open stoping technology for thin ore bodies in terms of the Irtysh complex ore mine. The key research methods are production planning and mathematical (numerical) stress–strain analysis and stability of structural elements in underground mines. The calculated parameters of pillars and stopes for open stoping ensure operating stoping in areas of steeply dipping or inclined ore bodies. Application of 3D mathematical modeling to geological and geomechanical conditions of an operating mine greatly expands the range of approaches and knowledge in complicated problem solving, which proves reliability and correctness of the results obtained for specific nonrecurring geotechnical situations.
Modeling the axially symmetric fracture evolution in deep-hole blasting
Authors: Sher EN 
Published: July 2020

Abstract
When blasting deep-hole charges in a brittle rock mass, rock disintegration mainly proceeds due to development of radial fractures induced by dramatic tensile azimuthal stresses in the vicinity of a charge and along its surface. Coincidently, appreciable tensile stresses are generated by blasting nearby ends of deep charges along their axes. Such stresses can initiate a rise and development of axially symmetric fractures. In the present paper the computational model is set forth for development of axially symmetric fractures nearby free surface in the vicinity of a charge end. Calculations of a fracture shape and size are reported.
Temperature effects on stress–strain behavior of underground openings in permafrost zone
Authors: Baryshnikov VD , Gakhova LN 
Published: July 2020

Abstract
The authors describe the research results on the temperature effects on the stress–strain behavior of rock mass around single openings driven in permafrost beyond the influence zone of stoping. The variation patterns of stresses and displacements in rock mass and at the boundary of an underground opening are found depending on its operating life and ventilation air temperature. In terms of the Aikhal mine of ALROSA, it is shown that in an opening at a depth of 350 m, given its ventilation temperature is 20 deg for 3 years, the vertical convergence is comparable with elastic displacements caused by the opening driving. An approach is proposed to determining rock stability category based on expected displacements of an opening during its ventilation. The research results are meant for guidelines and regulatory documents on justification of mine support designs in permafrost zone.
Determination of nonuniform stress field and rheological properties by caliper log measurements
Authors: Skulkin AA , Nazarova LA , Rubtsova EV 
Published: July 2020

Abstract
The authors formulate and solve the problem on finding nonuniform stress field and effective viscosity in the plane oriented orthogonally to a borehole axis drilled in rocks with rheological properties by the data of caliper logging using a viscoelastic model. From the numerical research with artificial input data, the effective viscosity range is determined, and the testing time such that the problem has the unique solution is found.
A tool for gas dynamic logging in drainage holes
Authors: Serdyukov SV 
Published: July 2020

Abstract
The paper presents the design and specifications of a modular down-the-hole logging tool to analyze gas dynamics in horizontal uncased drainage holes drilled from roadways. The tool incorporates a pneumatic push bar to advance the tool in the hole together with air hose and electric cable, an electro-drive air control, inflatable removable sealer and a flow rate for gas flow from a sealed section of a hole to its mouth. The author gives recommendations on using the tool in coal mines.
Background for engineering a continuous-operation soil drifter
Authors: Tishchenko IV 
Published: July 2020

Abstract
The paper discusses the feasibility of combining compaction and excavation processes in hole making. The continuous loop of hole-making and soil removal from hole pipe by compressed air return flow is proposed. Usability of an air hammer drill with elastic valve in the air distribution system in capacity of a drifter motor is examined. Using a physical dimension model with piston 4 kg in weight, the author refines energy and frequency performance of the pulse generator given the backpressure in the exhaust chamber. The experimental curves of the percussion capacity parameters are obtained.
Expansion of application range of pneumatic hammers with adjustable impact effect
Authors: Chervov VV 
Published: July 2020

Abstract
The author reviews briefly existing machines for trenchless laying of underground utilities and vertical driving of steel elements in soil. For a pneumatic hammer with ring and inertia valves for driving different diameter pipes, arrangement and operating principles are described. Powerful longitudinal forces generated by shocks ensure destruction of solid rocks or compaction of soil in the zone of hole-making. These forces can be used in implementation of other technologies as well. For instance, maintenance and rehabilitation of oil well centrifugal pumps, which requires complete disassembling of the machine. For taking of many parts (impellers and guide vanes) out of a hole (a pipe), a pneumatic hammer with piston weight of 40 kg was tested. Another application area of pneumatic hammers can be stimulation of caking material unloading from railway cars using a vibropercussion plant driven by pneumatic puncher. Replacement of the latter by a pneumatic hammer of the same size and performance can enhance efficiency of the process.
Ground control with backfill and caving in deep-level mining of gently dipping ore bodies
Authors: Vasichev SYu 
Published: July 2020

Abstract
The research aims to solve the relevant problem of ground control through the combination of backfill and caving in complicated geomechanical conditions of stoping in thick and gently dipping ore bodies with reliable support of overlying rocks. This problem is conditioned by the absence of data of ground control using a combination of mining methods with caving and cemented backfill, which attracts scientific interest and needs a deep insight. The problem was solved by means of finding regular patterns in stress distribution in different modulus rock mass and based on the sound selection of parameters for ore and artificial pillars, including shape and size of caving zone, such that to ensure stability of undermined rock strata, using the finite element method. It is found that alteration of trapezoid-shaped areas mined out by backfill with caving, as well as making more accurate dome of natural equilibrium in the roof caving zone improves mining safety.
Time variations in physicomechanical and acoustic properties of granite irradiated by accelerated electrons
Authors: Rostovtsev VI 
Published: July 2020

Abstract
In earlier R&D works executed at IM SB RAS the optimal dose of the granite treatment with accelerated electrons was experimentally established. It equals 10 kGy, this doze causes weakening of granite strength under uniaxial compression from 68.33 to 35.08 MPa, deformation modulus reduces from 13.19 to 7.04 GPa. This pretreatment permits to lower the compressive energy of granite core disintegration from 7.68 to 3.06 J and the crushing energy from 700.42 to 470.88 J. Of specific technological importance is dynamics of chronological variations in mineral properties after pretreatment of minerals with accelerated electrons. The present research aim is to study chronological variations in properties of granite, conventionally associated with deposits of such valuable elements, as Au, Sn, W, Mo, Li, Be, Rb, Bi, etc. The complex experiments on granite revealed that after a granite specimen is subjected to the high-energy electron irradiation, the increase in an absorbed dose causes first reduction in P- and S-waves velocities, then P- and S-wave velocities are growing and later again slowing down. The established experimental regularities of variations in granite properties relate to granite imperfections, specified by memory of the study rock. The most substantial variations in P- and S-waves velocities in the pretreated granite-core specimens within time interval up to 5360 hours after the irradiation are recorded for the adsorbed dose equal to 10 kGy. The established increase in P- and S-waves velocities versus a time interval after granite-core treatment with the adsorbed dose of more than 10 kGy could indicate a reduction in number of available imperfections and a probable strengthening of the study mineral material. Scientific novelty of the present research concerns the determination of chronological variations in granite properties and the beneficial feasibility to use the mineral weakening effect of in mineral processing operations.
Modern techniques to process Eastern Transbaikalia zeolite-bearing rock
Authors: Razmakhnin KK , Khatkova AN 
Published: July 2020

Abstract
Technological research results are used to substantiate the selection of an optimal technique to process zeolite-bearing rocks of Eastern Transbaikalia origin. The feasibility is established to improve appreciably a grade of zeolite-bearing materials by employing the target-action physical, physicochemical and energy techniques.
D-shape Fiber Coated with Indium Tin Oxide for Temperature Sensor Application
Authors: Nizamani B , Abdul Khudus M I M , Hanafi E , Harun S W 
Published: July 2020

Abstract
We designed a temperature sensor by using a D-shape fiber coated with indium tin oxide as a sensing probe. D-shape fiber was fabricated out of conventional single mode fiber by a homemade setup using wheel polishing technique. Insertion loss of D-shape fiber was about 3.5 dB. ITO was deposited over the D-shape fiber by electron-beam deposition technique to have precise deposition of 60nm thin film over the D-shape region of fiber to be utilized as a sensor. It is observed that the transmitted power increased with the increase in temperature with a sensitivity of 0. 0013 dBm/°C. The proposed sensor also provides a good linearity and stability.
Use of Software Engineering on the Project Implementation Schedule of Lamreung Limpok Bridge
Authors: Muhyi Abdul , Hamzi Miftahul , Busra  
Published: July 2020

Abstract
The development of technology is growing along with the time. It affects on development of construction management which several application programs are offered to facilitate construction management in term of implementing schedule and project data. The application program had facilitated the management to entry project data, manage project activities, project reports and control of project activities on lamreung limpok bridge, Lamgapang, Aceh besar, Aceh, Indonesia. The bridge incurred the expense of Rp.27.179.501.000.00 which it was supported by Aceh government budget 2018. The bridge connected the area of ulee kareng and limpok which the duration of project was 141 working days. This project consisted of 8 parameters in the activity that is the general work, drainage, work relate to land, aggregate pavement, asphalt pavement, structure, finishig, and maintenance. The issue of this study was the reach of project implementation schedule. This study will redesign the project schedule with the use of Microsoft Project 2013, The result showed that the duration of project was 122 working. Furthermore, the Gantt Chartand PDM had referred to the standard.
Pore Pressure Prediction using Anfis Method on Well and Seismic Data Field “Ayah”
Authors: Andrian D , Rosid M S , Septyandy M R 
Published: July 2020

Abstract
Nowadays oil and gas industries are focusing in production and development where well drilling is common and often done. One among many aspects need to be considered for drilling safety is pore pressure prediction. There are so many methods used in prediction the pressure including machine learning ANN but no one has ever done this with ANFIS which is combination of ANN and FIS machine learning. This study wants to use ANFIS for making a pore pressure distribution in 2D seismic data with 70% accuracy. Both pre-stack and post-stack seismic data are used here with well and RFT measurement. The modified Eaton-Azadpour and Eaton are two methods that applied to predict pore pressure. The methods are considered to be good in prediction pore pressure as they accommodate the rocks condition during drilling. The well parameters models are then distributed with ANFIS to find its correlation with P-impedance, S-impedance and density so we may find its distribution in 2D seismic data. The result shows that pore pressures are distributed very well but still need another study to give information regarding drilling safety.