bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary metastasis with coexisting pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma 20 years after endometrioid adenocarcinoma surgery: A case report
Authors: Nakamura Daisuke , Kobayashi Nobutaka , Miyazawa Masahisa , Miura Kentaro , Satomi Hidetoshi 
Published: December 2020

AbstractLate pulmonary metastasis from endometrioid adenocarcinoma (EA) is rare, and occurrence after >20 years is extremely rare. Here, we report a case of pulmonary metastasis with coexisting pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma that occurred 20 years after surgery for EA. A 60‐year‐old Japanese woman had previously undergone surgery for primary EA, and 20 years later presented with an abnormality that was detected on chest radiography. Chest computed tomography (CT) revealed two nodules in the right lower lung lobe, which were suspected to be primary lung cancer. Wedge resection was performed, and the intraoperative pathological diagnosis was that of adenocarcinoma with MALT lymphoma; this prompted additional right lower lobectomy. The final pathological diagnosis was pulmonary metastasis from EA with coexisting MALT lymphoma. This is probably the first report on late pulmonary metastasis coexisting with MALT lymphoma 20 years after surgery for EA. Surgeons should be aware of the possibility of late pulmonary recurrence of EA after more than 20 years and should consider aggressive resection.Key pointsSignificant findings of the studyAlthough extremely rare, pulmonary metastasis can occur more than 20 years after surgery for endometrioid adenocarcinoma. Furthermore, pulmonary metastasis from endometrioid adenocarcinoma may coexist with mucosa‐associated lymphoid tissue lymphoma.What this study addsEndometrioid adenocarcinoma requires long‐term postoperative follow‐up to detect recurrence, even in early‐stage cases. Video‐assisted thoracoscopic surgery (VATS) is useful for resecting pulmonary metastasis from endometrioid adenocarcinoma.
What factors enable mid‐life carers to re‐enter the labour market in New Zealand?
Authors: Spijker Jeroen J. A. , Alpass Fiona M. , Allen Joanne , Stephens Christine 
Published: December 2020

AbstractObjectiveTo assess the characteristics of carers and the caregiving situation associated with return to paid employment among older unemployed carers in New Zealand.MethodsA baseline sample of 280 unemployed carers was identified from responses by people aged 55‐70 to the 2012‐2016 biennial waves of the New Zealand Health, Work and Retirement longitudinal survey. Multiple logistic regression analysis was used to assess characteristics uniquely predicting employment status at two‐year follow‐up.ResultsSixteen percent were employed at follow‐up. Economic living standards, physical health and preference to be in paid employment were positively associated with being employed at follow‐up. There were no statistical differences according to age, gender, ethnicity, marital status, education and care characteristics.ConclusionIndividual preferences were the strongest predictor of return to paid employment. Despite New Zealand employment legislation allowing all employees to request flexible working arrangements, economic and health differences in workforce retention among carers persist.
Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study
Authors: Duan Lucy , Celik Alper , Hoang Jennifer A. , Schmidthaler Klara , So Delvin , Yin Xiaojun , Ditlof Christina M. , Ponce Marta , Upton Julia E.M. , Lee Jean‐Soo , Hung Lisa , Breiteneder Heimo , Palladino Chiara , Atkinson Adelle R. , Kim Vy H.D. , Berenjy Alireza , Asper Maria , Hummel David , Wong Samantha , Alexanian‐Farr Mara , Magder Ahuva , Chinthrajah Sharon R. , Mukai Kaori , Tsai Mindy , Nadeau Kari , Galli Stephen J. , Ramani Arun K. , Szepfalusi Zsolt , Eiwegger Thomas 
Published: December 2020

AbstractBackgroundPeanut and tree nut allergies are the most important causes of anaphylaxis. Co‐reactivity to more than one nut is frequent, and co‐sensitization in the absence of clinical data is often obtained. Confirmatory oral food challenges (OFCs) are inconsistently performed.ObjectiveTo investigate the utility of the basophil activation test (BAT) in diagnosing peanut and tree nut allergies.MethodsThe Markers Of Nut Allergy Study (MONAS) prospectively enrolled patients aged 0.5–17 years with confirmed peanut and/or tree nut (almond, cashew, hazelnut, pistachio, walnut) allergy or sensitization from Canadian (n = 150) and Austrian (n = 50) tertiary pediatric centers. BAT using %CD63+ basophils (SSClow/CCR3pos) as outcome was performed with whole blood samples stimulated with allergen extracts of each nut (0.001‐1000 ng/mL protein). BAT results were assessed against confirmed allergic status in a blinded fashion to develop a generalizable statistical model for comparison to extract and marker allergen‐specific IgE.ResultsA mixed effect model integrating BAT results for 10 and 100 ng/mL of peanut and individual tree nut extracts was optimal. The area under the ROC curve (AUROC) was 0.98 for peanut, 0.97 for cashew, 0.92 for hazelnut, 0.95 for pistachio, and 0.97 for walnut. The BAT outperformed sIgE testing for peanut or hazelnut and was comparable for walnut (AUROC 0.95, 0.94, 0.92) in a sub‐analysis in sensitized patients undergoing OFC.ConclusionsBasophil activation test can predict allergic clinical status to peanut and tree nuts in multi‐nut‐sensitized children and may reduce the need for high‐risk OFCs in patients.
Withdrawal of intensive care during times of severe scarcity: Triage during a pandemic only upon arrival or with the inclusion of patients who are already under treatment?
Authors: Dufner Annette 
Published: December 2020

AbstractMany countries have adopted new triage recommendations for use in the event that intensive care beds become scarce during the COVID‐19 pandemic. In addition to establishing the exact criteria regarding whether treatment for a newly arriving patient shows a sufficient likelihood of success, it is also necessary to ask whether patients already undergoing treatment whose prospects are low should be moved into palliative care if new patients with better prospects arrive. This question has led to divergent ethical guidelines. This paper explores the distinction between withholding and withdrawing medical treatment during times of scarcity. As a first central point, the paper argues that a revival of the ethical distinction between doing and allowing would have a revisionary impact on cases of voluntary treatment withdrawal. A second systematic focus lies in the concern that withdrawal due to scarcity might be considered a physical transgression and therefore more problematic than not treating someone in the first place. In light of the persistent disagreement, especially concerning the second issue, the paper concludes with two pragmatic proposals for how to handle the ethical uncertainty: (1) triage protocols should explicitly require that intensive care attempts are designed as time‐limited trials based on specified treatment goals, and this intent should be documented very clearly at the beginning of each treatment; and (2) lower survival prospects can be accepted for treatments that have already begun, compared with the respective triage rules for the initial access of patients to intensive care.
Deletion of the E3 ubiquitin ligase, Parkin, exacerbates chronic alcohol intake‐induced cardiomyopathy through an Ambra1‐dependent mechanism
Authors: Yang Mingjie , Wang Shuyi , Fu Shouzhi , Wu Ne N. , Xu Xihui , Sun Shiqun , Zhang Yingmei , Ren Jun 
Published: December 2020

Background and PurposeChronic alcohol consumption contributes to contractile dysfunction and unfavourable geometric changes in myocardium, accompanied by altered autophagy and disturbed mitochondrial homeostasis. The E3 ubiquitin ligase Parkin encoded by PARK2 gene maintains a fundamental role in regulating mitophagy and mitochondrial homeostasis, although little is known of its role in the aetiology of alcoholic cardiomyopathy. Here we assessed the effects of Parkin deletion in chronic alcohol‐evoked cardiotoxicity.Experimental ApproachFollowing alcohol (4%) or control diet intake for 8 weeks, adult male wild‐type (WT) and PARK2 knockout (Parkin−/−) mice were examined using echocardiography. Cardiomyocyte mechanical properties, morphology of myocardium, and mitochondrial damage were also evaluated. Autophagy and mitophagy levels were assessed by LC3B and GFP‐LC3 puncta, and lysosome‐dependent autophagic flux was scrutinized using GFP‐mRFP‐LC3 puncta and Bafilomycin A1 treatment.Key ResultsChronic alcohol exposure provoked unfavourable geometric changes in myocardium and led to mitochondrial dysfunction and cardiac contractile defects, effects further exacerbated by Parkin knockout. Chronic alcohol exposure provoked autophagy and PINK1/Parkin‐mediated mitophagy without affecting lysosome‐dependent autophagic flux, the effects of which were diminished by Parkin deletion. Parkin adenovirus infection in neonatal rat cardiomyocytes further increased autophagy and protected against alcohol‐induced myocardial injury, effects blocked by siRNA for Ambra1 (Autophagy and Beclin1 regulator 1). Immunofluorescence staining and co‐immunoprecipitation assays showed interactions between Parkin and Ambra1.Conclusions and ImplicationsParkin was essential for cardiac homeostasis in alcohol challenge, accompanied by increased autophagy/mitophagy and maintenance of mitochondrial integrity through its interaction with Ambra1.
Oxytocin in young children with Prader‐Willi syndrome: Results of a randomized, double‐blind, placebo‐controlled, crossover trial investigating 3 months of oxytocin
Authors: Damen Layla , Grootjen Lionne N. , Juriaans Alicia F. , Donze Stephany H. , Huisman T. Martin , Visser Jenny A. , Delhanty Patric J.D. , Hokken‐Koelega Anita C.S. 
Published: December 2020

AbstractContextPrader‐Willi syndrome (PWS) is characterized by hypothalamic dysfunction, hyperphagia and a typical behavioural phenotype, with characteristics of autism spectrum disorder (ASD) like stubbornness, temper tantrums and compulsivity. It has been suggested that the oxytocin system in patients with PWS is dysfunctional. In ASD, intranasal oxytocin treatment has favourable effects on behaviour.ObjectiveTo evaluate the effects of 3 months of twice daily intranasal oxytocin (dose range 16‐40 IU/day), compared to placebo, on behaviour and hyperphagia in children with PWS.DesignRandomized, double‐blind, placebo‐controlled, crossover study in the Dutch PWS Reference Center.PatientsTwenty‐six children with PWS aged 3‐11 years.Main outcome measures(Change in) behaviour and hyperphagia measured by Oxytocin Questionnaire and Dykens hyperphagia questionnaire.ResultsIn the total group, no significant effects of oxytocin on social behaviour or hyperphagia were found. However, in boys, the Oxytocin Questionnaire scores improved significantly during oxytocin treatment, compared to a deterioration during placebo (4.5 (−0.8 to 15.3) vs. −4.0 (−11.3 to 0.8), P = .025). The Dykens hyperphagia questionnaire scores remained similar during oxytocin treatment, while there was a deterioration during placebo (0.0 (−0.8 to 4.3) vs. −3.5 (−6.0 to 0.0), P = .046). Patients with a deletion had significant improvements in both questionnaire scores during oxytocin treatment, but deteriorations during placebo. Oxytocin treatment was well tolerated, and there were no serious adverse events.ConclusionsIntranasal oxytocin treatment has positive effects on social and eating behaviour in 3‐11 years aged boys with PWS and in children with a deletion without safety concerns. Intranasal oxytocin in children with PWS might be considered, but individual effects should be carefully evaluated and treatment discontinued if no effects are found.
Simulation and performance analysis of 15 NmFinFETbased carry skip adder
Authors: Duraivel N. , Paulchamy B. 
Published: December 2020

AbstractVarious changes in the advanced semiconductor industry, designing adder with higher performance is a major concern. These proposed works constrain the major area in FinFET designing at the range of 15‐nm FinFET technology at 25°C. By designing the FinFET technology with the range of 15 nm is the rising transistor technology with the lesser delay and the management in the power tradeoff. FinFET technology makes the evolutionary step in the semiconductor field because various adders have various complications in scaling at the range of 15 nm. The speed reinforcement is used based on various schemes to improve the efficiency of the conventional carry skip adder (Conv‐CSKA) structure. By taking into account multiplexer logic, the proposed designing structure made in the account of AND‐OR‐Invert (AOI) and OR‐AND‐Invert (OAI) compound gates which are used as the skip logic. The simulation is carried out using HSPICE and Tanner. In various research works, it is concluded that the FinFET based adders are implemented in the semiconductor devices which are the advanced part of the computerized technique with the advancement in the designing circuits. The proposed designing structure includes the 8 T adders which reduce the power consumption with different datapath. The modified designing increases the slack time and decreases the input voltage. This article implements the comparison of FinFET designing based on their speed, power, and energy with the other adder circuits using 15‐nm FinFET technology.
Peroxidase‐catalysed coloration of wool fabrics
Authors: Netithammakorn Nalinee , Smith Edward , Lerpiniere Claire , Shen Jinsong 
Published: December 2020

AbstractAn enzyme‐based textile coloration process using peroxidase (EC1.11.1.7) was investigated for its potential as an alternative to conventional textile dyeing processes, with the benefits of being low in energy use and non‐damaging to fibres. The current study presents a process for the coloration of wool fabric using peroxidase oxidation of a range of different aromatic compounds in the presence of hydrogen peroxide. The results revealed that wool can be successfully dyed by peroxidase‐catalysed coloration at temperatures as low as 30°C. By controlling the pH values and buffer systems during processing, a diverse colour palette was produced, depending on the small molecular aromatic compound used as the precursor. Colour fastness testing found that fastness to washing, rubbing and light properties achieved good to excellent ratings, with further improvement to wash fastness provided by a post‐soaping wash. No fibre damage occurred due to peroxidase‐catalysed coloration. This enzyme coloration process is a promising alternative to conventional wool dyeing processes with the advantage of effective dyeing at low temperatures, therefore having the potential of reducing energy consumption and preventing fibre damage.
A novel reaction‐based fluorescent probe sensitive to pH changes in multiple intervals
Authors: Li Hongqi , Chen Zhen , Zheng Tao , Hu Luping , Song Yanxi , Zhang Ruiqing , Zhang Xin 
Published: December 2020

AbstractA new coumarin derivative containing both imine bond and amide moiety was synthesised. It was used as a reaction‐based pH probe and was sensitive to pH changes in the intervals 1.50–4.10 and 10.20–12.86. In the pH range 1.50–4.10, the ultraviolet‐visible (UV‒vis) absorption band of the probe gradually shifted from 353 nm to 340 nm with decrease in the pH value. The colour changed from pale yellow fluorescence at pH 4.10 to blue fluorescence at pH 1.50. Meanwhile the fluorescence emission band at 501 nm gradually shifted to 560 nm accompanying a gradual enhancing in the emission intensity. This pH response is caused by the hydrolysis of the imine bond in the probe under acidic conditions (pH 1.50–4.10). The colourless probe solution turned yellow at pH range 10.20–12.86. Bathochromic shift of the fluorescence band from 501 nm gradually to 550 nm was observed with the increase of pH value from 10.20 to 12.86 accompanying a gradual enhancement of the fluorescence emission intensity, indicating that the new compound serves as a fluorescent pH probe at pH range 10.20–12.86 through a deprotonation process. Under strongly alkaline conditions with pH larger than 12.86, hydrolysis of the lactone structure in the probe occurred to produce non‐fluorescent species.
Cutaneous acantholytic dyskeratotic acanthoma accompanying syringofibroadenomatous hyperplasia with proliferation of mature sebocytes: A case report
Authors: Tanaka Chiharu , Kurabayashi Atsushi , Furihata Kaoru , Iwashita Waka , Naganuma Seiji , Toi Makoto , Yano Akiko , Furihata Mutsuo 
Published: December 2020

AbstractAcantholytic dyskeratotic acanthoma is a rare variant of epidermal acanthoma. It has a flat, plaque‐like structure and is characterized microscopically by acantholysis and dyskeratosis. Eccrine syringofibroadenomatous hyperplasia is benign and likely reactive. It has recently been considered as a hyperplastic process affecting the eccrine ducts rather than the neoplasm because of its pathological heterogeneity and wide clinical associations. In this article, we present the case of 97‐year‐old Japanese women with a 10‐mm wide, painful acantholytic dyskeratotic acanthoma accompanied by syringofibroadenomatous hyperplasia in the right femoral region. Although syringofibroadenomatous hyperplasia is known to occur as a reactive process with various dermatoses and cutaneous tumors, to date, there have been no reports of cases of acantholytic dyskeratotic acanthoma accompanying syringofibroadenomatous hyperplasia. Moreover, this case also includes the unusual finding of an increase in the mature sebocytes in the area of the syringofibroadenomatous hyperplasia.
The value of identification scanner technology in monitoring and detecting banned patrons in entertainment precincts
Authors: de Andrade Dominique , Puljević Cheneal , Miller Peter G. , Taylor Nicholas , Curtis Ashlee , Ferris Jason 
Published: December 2020

AbstractIntroduction and AimsNetworked identification (ID) scanner technology is a novel approach to collecting licensed venue attendance data, and potentially reducing alcohol‐related violence by detecting banned patrons. Using ID scanner data from three Queensland entertainment precincts (Safe Night Precincts; SNPs), we aim to: (i) examine patterns in patron attendance to licensed venues; and (ii) examine patterns in the detection of banned patrons.Design and MethodsWe conducted descriptive analyses of licensed venue patron entries between 1 October 2017 and 30 June 2019. Scans during high alcohol hours (Friday and Saturday, 20:00–06:00) were stratified by patron sex and key age groups. We described scans associated with a detected banning notice issued by venues, courts or police across all Queensland SNPs and three key SNPs.ResultsID scanner data showed similar attendance trends across SNPs. The peak licensed venue entry hour was 23:00–23:59, with Saturday being the peak day. Approximately two‐thirds of scanned patrons were male, and patrons had a mean age of 25.8 years (SD = 8.80). Scanners detected 48 657 attempted entries by banned patrons, with the majority of attempts made by males (85%) aged 18–24 years (61%).Discussion and ConclusionsThis study adds to the limited evidence on the use of ID scanners in the night‐time economy and highlights the feasibility of ID scanner use in this setting. Results demonstrate the value of scanners to passively collect data on patrons, identify banned patrons and assist in the enforcement of bans.
Ecological uniqueness of species assemblages and their determinants in forest communities
Authors: Yao Jie , Huang Jihong , Ding Yi , Xu Yue , Xu Han , Zang Runguo 
Published: December 2020

AbstractAimBeta diversity can be partitioned into the contributions of individual sampling units to overall beta diversity, which are comparative indicators of the ecological uniqueness of species assemblages in the sampling units. Yet, what determines ecological uniqueness has rarely been examined. Here, we investigated the determinants of ecological uniqueness in species assemblages in forest communities.LocationChina.MethodsWe used tree census data, combined with spatially explicit environmental variables collected from forest dynamics plots across tropical, subtropical and temperate forests in China. We computed beta diversity as the total variation of the community data, and a site‐based approach was used to determine whether ecological uniqueness is related to local environmental conditions and/or community characteristics.ResultsEcological uniqueness was explained by both local environment and community characteristics, but their relative importance varied across the four forest types. We provide direct evidence that the relationship between ecological uniqueness and species richness (EUSRR) is related to the percentage of rare species in the community. Local environmental factors affecting ecological uniqueness and beta diversity were inconsistent, indicating that focusing simultaneously on beta diversity and ecological uniqueness with regard to local environmental conditions is likely to be the appropriate approach to study forest community assembly.Main conclusionsAlthough the EUSRR was negative in some cases, indicating high species richness, this does not necessarily imply high ecological uniqueness. Thus, for biological conservation, species‐rich sites and unique low‐richness sites should be valued more. The higher degree of ecological uniqueness indicates unique species compositions, which provides insight into finding such quadrats and taking measures for protection, restoration or management. We propose that focusing simultaneously on the beta diversity, species richness and ecological uniqueness of individual quadrats is likely to be a valuable approach for biodiversity conservation programmes.
Susceptible host availability modulates climate effects on dengue dynamics
Authors: Nova Nicole , Deyle Ethan R. , Shocket Marta S. , MacDonald Andrew J. , Childs Marissa L. , Rypdal Martin , Sugihara George , Mordecai Erin A. 
Published: December 2020

AbstractExperiments and models suggest that climate affects mosquito‐borne disease transmission. However, disease transmission involves complex nonlinear interactions between climate and population dynamics, which makes detecting climate drivers at the population level challenging. By analysing incidence data, estimated susceptible population size, and climate data with methods based on nonlinear time series analysis (collectively referred to as empirical dynamic modelling), we identified drivers and their interactive effects on dengue dynamics in San Juan, Puerto Rico. Climatic forcing arose only when susceptible availability was high: temperature and rainfall had net positive and negative effects respectively. By capturing mechanistic, nonlinear and context‐dependent effects of population susceptibility, temperature and rainfall on dengue transmission empirically, our model improves forecast skill over recent, state‐of‐the‐art models for dengue incidence. Together, these results provide empirical evidence that the interdependence of host population susceptibility and climate drives dengue dynamics in a nonlinear and complex, yet predictable way.