bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Characteristics of Risk Factors in Chinese Young Women with Acute Coronary Syndrome
Authors: Liu Ruifang , Xu Fangxing , Zhou Yujie , Liu Tongku 
Published: March 2020

Abstract
Background In recent years, the prevalence rate of ACS in Chinese young women has been increasing significantly, becoming the main cause of death in young female. This study aimed to investigate the characteristics and difference of risk factors in Chinese young women with ACS and to provide references for ACS prevention and treatment. Methods A 1:1 case-control study was conducted to evaluate risk factors of 415 young female patients with ACS (ACS group) who underwent PCI treatment and 415 young female cases without ACS (control group) who were hospitalized and confirmed by coronary angiography to exclude coronary heart disease from January 2010 to August 2016. The average age of the cases in the two groups was respectively (40.77±4.02) years-old and (40.57±4.01) years-old (P> 0.05). Results The risk factors in ACS group were overweight (64.10%), hypertension (49.88%), hyperlipidemia (35.66%), diabetes (23.37%), depression or anxiety disorder (16.62%), gynecological diseases (16.39%), Hyperuricemia (15.18%), family history of early onset coronary heart disease (14.94%), hyperhomocysteinemia (11.33%), hypothyroidism(14.96%), hypercholesterolemia (8.43%) and high c-reactive protein (7.47%), and were statistically significant difference (P<0.01) compared with that of control group. The average number of risk factors per case in ACS group was significantly more than that of control groups (P<0.01). There was a statistically significant difference in the number of combined risk factors of the overweight cases compared between two groups (P<0.01). Regression analysis showed that hyperlipidemia, hyperhomocysteinemia, overweight（obesity）, high CRP, hypertension, hypothyroidism, gynecological diseases, depression or anxiety, cardiac insufficiency, hypercholesterolemia, diabetes, oral contraceptives, family history of early onset CHD, and autoimmune diseases were independent risk factors (P<0.01). The bivariate correlation analysis between CRP level and age was r= -0.158 (P<0.01). This result showed the younger ACS patient is the higher serum CRP. Conclusion The independent risk factors of ACS in young women are hyperlipidemia, hyperhomocysteinemia, overweight, high CRP, hypertension, hypothyroidism, gynecological diseases, depression or anxiety, cardiac insufficiency, hypercholesterolemia, diabetes, oral contraceptives, family history of early onset CHD, and autoimmune diseases. The co-existence of multiple risk factors is the main cause suffering from ACS in young women.
Use of powder silicon as a photocurable resin filler for laser stereolithography and prospects for transforming stereolithographic parts with silicon from polymeric to ceramic ones.
Authors: Markov Michael , Vnuk Vyacheslav , Ippolitov Evgeny , Kamaev Sergey , Cherebylo Svetlana 
Published: March 2020

Abstract
The article deals with the peculiarities of using silicon micropowder as a chemically inert filler when creating photocurable resins (PCR) for laser stereolithography. The authors provide the results of their experiments on making three-dimensional parts from such resins and discuss the feasibility of transforming the parts from polymeric, containing a filler, into ceramic ones through annealing. The use of silicon allows for a two-fold increase in the mass of the ceramic component due to the interaction of silicon with air oxygen and with products resulting from the thermal decomposition of the photopolymer's polymer base.
Pur-alpha participates in the progression of Alzheimer's disease through direct and indirect ways
Authors: Shi Xiaoguang , Ren Shuanglai , Zhang Bingying , Guo Shanshan , He Wenxin , Yuan Chengmin , Yang Xiaofan , Ig-lzevbekhai Kevin , Sun Tao , Wang Qinwen , Cui Jianqi 
Published: March 2020

Abstract
Background: Purine rich element binding protein A (Pur-alpha)，encoded by the PURA gene， is an important transcriptional regulator that binds to DNA and RNA and is involved in processes such as DNA replication and RNA translation. Pur-alpha plays an important role in the nervous system. Our previous research found that the regulatory effect of Pur-alpha on APP suggests that it may be involved in the production of beta-amyloids. Suggestting that Pur-alpha may plays a role in Alzheimer ’s disease (AD), but the relevant evidence is insufficient.Methods: We performed RNA-sequencing (RNA-seq) analysis of Pura-KO mouse hippocampal neuronal cell line (HT22) to analyze the effect of puralpha deletion on neuron expression profile. And then combined with ChIP-seq analysis to explore the mechanism of Pura on gene regulation.Results: we found 656 differentially expressed genes between HT22 and Pura-KO HT22. A total of 62 overlapping genes were found by comparison with early brain protein expression profiles in mice, which may play important role in early neuronal development. We found 7 Alzheimer’s disease (AD)-related genes (Lpl, Mapt, Mme, Ndufa3, Lrp1, Gapdh, mt-Co3) and 5 Ab clearance related genes (Mme, C3, Lrp1, Insr, Trem2) were regulated by Pur-alpha, suggesting that Pur-alpha plays an important role in AD. Through ChIP-seq analysis, we found that Pur-alpha binds directly to 47 genes and regulates their transcription, including Insr, Mapt, Vldlr, Jag1, etc. The direct regulation of Vldlr，the Reelin ligand，suggests that Pur-alpha may be involved in the process of synaptic plasticity. The direct regulation of Jag1 suggests that Pur-alpha may be involved in the Notch pathway.Conclusions: Our study re-confirms the important role of Pur-alpha in neurodevelopment. The regulation of Pur-alpha on AD-related genes means that Pur-alpha plays an important role in the pathogenesis of AD.
Nutritional Perspectives On Sickle Cell Disease In Africa: A Systematic Review
Authors: Nartey Eunice Berko , Spector Jonathan , Adu-Afarwuah Seth , Jones Catherine L. , Jackson Alan A. , Ohemeng Agartha , Shah Rajiv , Koryo-Dabrah Alice , Kuma Amma Benneh-Akwasi , Hyacinth Hyacinth I. , Steiner-Asiedu Matilda 
Published: March 2020

Abstract
Background

Sickle Cell Disease (SCD) is an inherited blood disorder and mostly affects individuals living in sub-Saharan Africa. Whilst there is an established link between its pathophysiology and nutritional status, research in this area in Africa is limited and evidence-based nutritional guidelines lacking. This systematic review aimed to evaluate studies in sub-Saharan Africa focused on nutritional aspects of SCD, codify results, and highlight gaps in knowledge that could inform priority-setting for future research.

Methods

The study was conducted using the Preferred Reporting items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We sought to include all studies involving original research of nutritional status of individuals (children and adults) with SCD in Africa. ‘Nutritional status’ was defined as topics related to dietary intake, measurements of growth or anthropometry, and nutritional-related biomarkers. Studies of anemia alone in non-SCD individuals were excluded as well as studies that assessed individuals with sickle cell trait (i.e., carriers). The databases used were Ovid Embase, Medline, Biosis and Web of Science. Studies conducted between 1995 and 2018 were included in the analyses.

Results

The search returned 366 articles from which 66 studies were included in the final analyses. Most investigations (70%) were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (47% of studies), descriptive studies of macro- or micronutrient levels (36% of studies), and interventional studies (14% of studies). There were fairly uniform findings that demonstrate that the growth of SCD patients in sub-Saharan Africa was impaired, especially in childhood and adolescence. Studies assessing macro- and micro-nutrients generally had small sample sizes and were exploratory in nature. Only two randomized, placebo-controlled trials were identified, which measured the impact of fatty acid supplementation and lime juice on health outcomes.

Conclusions

The findings of this review are consistent with data from other regional settings that describe a significant risk of malnutrition in individuals with SCD. There appears to be a substantial unmet need for clinical research to better understand the potential utility of nutritional-related interventions for patients with SCD in sub-Saharan Africa, to promote optimal growth and improve health outcomes.
Identification and validation of quantitative trait loci for ascites syndrome in broiler chickens using whole genome resequencing.
Authors: Parveen Alia , Jackson Christa , Dey Shatovisha , Tarrant Katy , Anthony Nicholas B , Rhoads Douglas 
Published: March 2020

Abstract
Background Ascites syndrome is a hypertensive, multifactorial, multigene trait affecting meat-type chickens imposing significant economic losses on the broiler industry. A region containing the CPQ gene has been previously identified as significantly affecting ascites phenotype. The region was discovered through whole genome resequencing focused on chicken chromosome 2. The association was confirmed through further genotyping in multiple broiler populations. Results The whole genome resequencing analyses have now been extended to the current chicken genome assembly. DNA samples were pooled according to gender and phenotype and the pools subjected to next generation sequencing. Loci were identified as clusters of single nucleotide polymorphisms where frequencies of the polymorphisms differed between resistant and susceptible chickens. The chickens are an unselected line descended from a commercial elite broiler line. Regions identified were specific to one or both genders. The data identify a total of 28 regions as potential quantitative trait loci for ascites. The genes from these regions have been associated with hypertensive-related traits in human association studies. One region on chicken chromosome 28 contains the LRRTM4 gene. Additional genotyping for the LRRTM4 region demonstrates an epistatic interaction with the CPQ region for ascites phenotype. Conclusions The 28 regions identified were not previously identified in a multi-generational genome wide association study using 60k Single Nucleotide Polymorphism panels. This work demonstrates the utility of whole genome resequencing as a cost effective, direct, and efficient method for identifying specific gene regions affecting complex traits. The approach is applicable to any organism with a genome assembly and requires no a priori assumptions.
Integrating transcriptomic and metabolomic analysis of hormone pathways in Acer rubrum during developmental leaf senescence
Authors: Zhu Chen , Xiaoyu Lu , Junlan Gao , Yun Xuan , Ren Jie 
Published: March 2020

Abstract
Background: To fully elucidate the roles and mechanisms of plant hormones in leaf senescence, we adopted an integrated analysis of both non-senescing and senescing leaves from red maple with transcriptome and metabolome data.Results: Transcription and metabolite profiles were generated through a combination of deep sequencing, third-generation sequencing data analysis, and ultrahigh-performance liquid chromatograph Q extractive mass spectrometry (UHPLC-QE-MS), respectively. We investigated the accumulation of compounds and the expression of biosynthesis and signaling genes for eight hormones. The results revealed that ethylene and abscisic acid concentrations increased during the leaf senescence process, while the contents of cytokinin, auxin, jasmonic acid, and salicylic acid continued to decrease. Correlation tests between the hormone content and transcriptional changes were analyzed, and in six pathways, genes closely linked with leaf senescence were identified.Conclusions: These results will enrich our understanding of the mechanisms of plant hormones that regulate leaf senescence in red maple, while establishing a foundation for the genetic modification of Acer in the future.
Sacral incidence to pubis: a novel and alternative morphologic radiological parameter to pelvic incidence in assessing spinopelvic sagittal alignment
Authors: Takahashi Yasuhito , Watanabe Kei , Okamoto Masashi , Hatsushikano Shun , Hasegawa Kazuhiro , Endo Naoto 
Published: March 2020

Abstract
Background: Although pelvic incidence (PI) is a key morphologic parameter in assessing spinopelvic sagittal alignment, accurate measurements of PI become difficult in patients with severe hip dislocation or femoral head deformities. This study aimed to investigate the reliability of our novel morphologic parameters and the correlations with established sagittal spinopelvic parameters.Methods: One hundred healthy volunteers (25 male and 75 female), with an average age of 38.9 years, were analysed. Whole-body alignment in the standing position was measured using a slot-scanning X-ray imager. We measured the established spinopelvic sagittal parameters and two original parameters: 1) the sacral incidence to pubis (SIP), which is the value of the angle between the line perpendicular to the superior plate of the first sacral vertebra at its anterior edge and the line connecting this point to the upper edge of the pubic symphysis, and 2) the pelvic inclination angle (PIA).Results: Reliability analysis showed high intra- and inter-rater agreements in all the spinopelvic parameters, with ICCs > 0.9. The SIP and PIA demonstrated strong correlation with PI (R = 0.96) and pelvic tilt (PT) (R = 0.92), respectively. PI could be predicted according to the regression equation: PI = –9.92 + 0.905 * SIP (R = 0.9596, p < 0.0001). The ideal lumbar lordosis (LL) could be predicted using the following equation using PI and age: ideal LL = 32.33 + 0.623 * PI – 0.280 * age (R = 0.6033, p < 0.001) and using SIP and age: ideal LL = 24.29 + 0.609 * SIP – 0.309 * age (R = 0.6177, p < 0.001).Conclusion: Both SIP and PIA were reliable parameters for determining the morphology and orientation of the pelvis, respectively. Ideal LL was accurately predicted using the SIP with equal accuracy as the PI. Our findings will assist clinicians in the assessment of spinopelvic sagittal alignment, decision-making, and ultimately help improve patient quality of life.
More than six weeks to resolve from CT manifestations in COVID-19 patient: A case report
Authors: Xu Wenxiong , Lei Ziying , Chen Dabiao , Li Xuejun , Huang Zhanlian , Liu Jing , Gao Zhiliang , Peng Liang 
Published: March 2020

Abstract
Background: Coronavirus Disease 2019 (COVID-19) outbroke in Wuhan and spread to the world recently. But there were little studies on how long it took to recover from treatment beginning and resolve from chest computed tomography (CT) imaging so far.Case presentation: A patient diagnosed with severe type of COVID-19 was reported in this study. He was the first patient recovered and discharged from our hospital located in Guangzhou city. Initial chest computed tomography (CT) images of him showed bilateral multiple lobular peripheral ground-glass opacities without consolidation. Features and changes of his chest CT images from admission to discharge and follow-up were demonstrated. It took more than six weeks for lesion resolution in CT manifestations although the symptoms improved for a period of time after proper treatment. Conclusions: Repeated chest CT imaging for a period of more than six weeks in patients of COVID-19 is necessary to ascertain the lesion resolution and completely recovery. The result could be supplementary data to COVID-19 and help health care providers manage the COVID-19 patients.
Conocimiento, formación y uso de herramientas TIC aplicadas a la Educación Superior por el profesorado de la Universidad Miguel de Cervantes
Authors: Venegas-Ramos Luis , Luzardo Martínez Hendry J. , Pereira Santana Adrián 
Published: March 2020

El presente estudio tuvo por objeto conocer el nivel de conocimiento, formación y aplicación que posee el profesorado de la Universidad Miguel de Cervantes (Chile) sobre las herramientas TIC en su práctica personal y docente. La investigación fue de tipo descriptivo - correlacional, con diseño no experimental y de carácter transeccional; desarrollada mediante la aplicación de una encuesta debidamente validada. Los datos recogidos han permitido establecer que los docentes de la UMC hacen una subutilización de las herramientas TIC en su práctica docente, debido a una falta de conocimiento y formación ad hoc, y a la falta de políticas institucionales que garanticen el proceso de integración tecnológico – curricular al interior de la Universidad.
Okul Çapında Olumlu Davranışsal Destek Modeli ve İkincil Düzey Müdahalelere Bakış
Authors: ATBAŞI Zehra 
Published: March 2020

Öğrencilerin temel sosyal becerilerini geliştirmeye odaklanan Okul Genelinde Olumlu Davranışsal Destek (OGODD), problem davranışları belirleyerek uygun davranışları öğretmek için veriye dayalı bir sistem kullanmaktadır. OGODD ekip çalışmasına dayanan, anaokulundan, liseye kadar pek çok okul ve kademesinde uygulanan bir yapı özelliği taşımaktadır. Okuldaki bütün öğrencileri kapsayan OGODD, tüm öğrencilere ve okul personeline güvenli ve olumlu okul ortamı sunmaktadır. Sunulan destekler okul genelinde, sınıfta ve bireysel müdahaleler biçiminde yürütülmektedir. Her okulun kendine özgü kapsamlı bir sistem kurmasına olanak sağlayan OGODD, öğrencilere yönelik tüm desteği kanıta dayalı olarak sunan bir sistem yaklaşımıdır. OGODD çeşitli stratejiler yoluyla ulaşılan ana bileşenleri bulunan bir yaklaşım olmasına rağmen paket bir program değildir ve üç aşamalı piramit modeliyle açıklanmaktadır. Üç aşamalı bu modelde okuldaki tüm öğrencilerin ihtiyaçlarına yönelik uygulamalar bulunmaktadır. Bu çalışmanın amacı, OGODD modelinin çerçevesini, bu çerçevede sunulan ikincil düzey müdahaleleri ve ikincil düzey müdahalelerde, öğrencilerin ihtiyaçlarını en iyi şekilde karşılanmasını sağlamaya yönelik yapılması gerekenleri tanımlamaktır. Ayrıca, okulların ikincil düzey müdahalelerini hem başlangıç hem de devam eden uygulanma sürecinde nasıl planladığını açıklayarak gelecekteki araştırma ve uygulamalara ışık tutmak amaçlanmıştır.
Intranasal Lipid Particulate Drug Delivery Systems: An Update on Clinical Challenges and Biodistribution Studies of Cerebroactive Drugs in Alzheimer’s disease
Authors: Arora Deepshi , Bhatt Shailendra , Kumar Manish , Vattikonda Hari D.C. , Taneja Yugam , Jain Vishal , Joshi Veenu , Gali Chaitanya C. 
Published: March 2020

Background:
Alzheimer is the primary cause of death in the various countries that affects wide strata of the
population. The treatment of it is restricted to a few conventional oral medications that act only superficially. It is
evident that the delivery of a drug to the brain across the blood-brain barrier is challenging as the BBB is armed with
several efflux transporters like the P-glycoprotein as well as nasal mucociliary clearance adds up leading to
decreased concentration and reduced therapeutic efficacy. Considering these, the intranasal IN route of drug
administration is emerging as an alternative route for systemic delivery of a drug to the brain. The intranasal (IN)
administration of lipid nanoparticles loaded with cerebroactive drugs showed promise in treating various
neurodegenerative diseases, since the nasal route allows the direct nose to brain delivery by means of solid lipid
nanoparticles (SLN’s). The tailoring of intranasal lipid particulate drug delivery systems is a pleasing approach to
facilitate uptake of therapeutic agents at the desired site of action, particularly when a free drug has poor
pharmacokinetics/ biodistribution (PK/BD) or significant off-site toxicities.

Objectives:
1) In this review, key challenges and physiological mechanisms regulating intranasal brain delivery in
Alzheimer’s disease, ex vivo studies, pharmacokinetics parameters including brain uptake and histopathological
studies are thoroughly discussed.

:
2) A thorough understanding of the in vivo behaviour of the intranasal drug carriers will be the elusive goal.

:
3) The article emphasizes to drag the attention of the research community working in the intranasal field towards
the challenges and hurdles of the practical applicability of intranasal delivery of cerebroactive drugs.

Method:
Various electronic databases, journals like nanotechnology and nanoscience, dove press are reviewed for
the collection and compilation of data.

Results:
From in vivo biodistribution studies, pharmacokinetics parameters, and gamma scintigraphy images of
various drugs, it is speculated that intranasal lipid particulates drug delivery system shows better brain targeting
efficiency for various CNS disorders in comparison to other routes.

Conclusion:
Various routes are explored for the delivery of drugs to increase bioavailability in the brain for CNS
disorders but the intranasal route shows better results that pave the way for success in the future if properly explored.
The Effect of Narrative on Physical Activity via Immersion During Active Video Game Play in Children: Mediation Analysis
Authors: Sousa Caio Victor , Fernandez Austin , Hwang Jungyun , Lu Amy Shirong 
Published: March 2020

BackgroundActive video games (AVGs) can increase physical activity (PA) and help produce higher physiological expenditure. Animated narrative videos (NVs) possess unique immersive and motivational properties. When added to AVGs, they have been found to increase moderate-to-vigorous physical activity (MVPA) as opposed to the original no video condition. However, there is no evidence of whether that was due to the NV or the addition of an animated video to an AVG.ObjectiveThis study aimed to investigate the differential effect of adding an NV versus a nonnarrative video (NNV) to an AVG on PA parameters and physiological responses and to explore the mediating role of immersion.MethodsA total of 22 children aged 8 to 12 years were randomly assigned to the NV or NNV condition. They were instructed to play an AVG (on Xbox Kinect) for as long as they wanted. We used accelerometers to estimate the time spent (in minutes) in MVPA. Heart rate (HR) and rate of perceived exertion (RPE) were measured before, during, and after the AVG play session. The participants then reported their experience of narrative immersion via a questionnaire.ResultsThe NV group had significantly higher narrative immersion (mean 3.50, SD 0.55 vs mean 2.91, SD 0.59; P=.03) and MVPA (mean 19.46, SD 13.31 vs mean 7.85, SD 5.83; P=.02) than the NNV group. Narrative immersion was positively correlated with MVPA (r=0.52; P=.01) and average HR during AVG (r=0.43; P=.05). Mediation analysis indicated that narrative immersion mediated the effect of NV (NV vs NNV) on MVPA (direct effect: beta=7.51; P=.01). The indirect effect was that NV was positively correlated with the mediator variable narrative immersion (beta=.59; P=.03), which was itself marginally associated with MVPA (beta=6.95; P=.09); when narrative immersion was included in the model, the regression coefficient was attenuated.ConclusionsAVG with added narratives elicits more narrative immersion, resulting in more minutes in MVPA. Narrative immersion served as a mediator between NV and MVPA via its elicitation of an elevated HR without increasing RPE. The inclusion of immersive narratives in AVG could be helpful for inducing MVPA, to enhance AVG engagement without additional exertion.