bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombolysis Outcomes in Patients with Diabetes and Previous Stroke: A Meta-Analysis
Authors: Pajo Azalea T. , Diestro Jose Danilo B. , Espiritu Adrian I. , Dmytriw Adam A. , Enriquez-Marulanda Alejandro , Sarmiento Robert Joseph C. , Bagnas Marjorie Anne C. , Spears Julian , San Jose Maria Cristina Z. 
Published: April 2020

ABSTRACT:Background:Intravenous tissue-type plasminogen activator (IVtPA) is a proven treatment for acute ischemic stroke; however, diabetes mellitus (DM) and previous cerebral infarction (PCI) were considered relative contraindications for thrombolysis within the 3–4.5 h period.Objective:The study aimed to determine the safety and efficacy of IVtPA among diabetic patients with PCI presenting with acute ischemic stroke.Methods:Studies which evaluated the outcome of IVtPA in terms of symptomatic intracerebral hemorrhage (sICH), functional outcome in modified Rankin scale, and death among diabetic patients with PCI presenting with acute ischemic stroke within the 3–4.5 h period were systematically searched until July 2019. Screening and eligibility criteria were applied. Risk of bias was evaluated using the Newcastle–Ottawa Scale. Odds ratios (ORs) with 95% confidence interval (CI) were used to compare measures of treatment effect. Mantel–Haenszel method and random-effects model were also employed.Results:Four registry-based studies with a total of 44,572 patients were included for quantitative synthesis. Giving IVtPA among DM+/PCI+ patients did not result in significantly increased rate of sICH (OR, 1.09; 95% CI, 0.88, 1.36) compared to No DM+/PCI+ patients. However, there was significantly higher mortality (OR, 1.81; 95% CI, 1.60, 2.06) in the DM+/PCI+ group. Conversely, among those who survived, the DM+/PCI+ patients were more functionally independent at 3 months (OR, 0.76; 95% CI, 0.61, 0.94).Conclusion:Limited evidence suggests that thrombolysis in DM+/PCI+ patients does not result in significantly higher incidence of sICH and may improve functional independence. However, the significantly higher mortality in this group warrants an assessment of the individualized risk–benefit ratio in the use of IVtPA.
High-power operation of double-pass pumped Nd:YVO4 thin disk laser
Authors: Wang Wei , Sun Di , Du Xiao , Guo Jie , Liang Xiaoyan 
Published: April 2020

A simple, compact, double-pass pumped Nd:YVO4 thin disk laser is demonstrated. Its continuous-wave performance with different Nd doping concentrations and thicknesses is investigated experimentally. The maximum output power of 17.7 W is achieved by employing a 0.5 at.% doped sample, corresponding to an optical-to-optical efficiency of 46% with respect to the absorbed pump power. In addition, a numerical analysis and an experimental study of the temperature distribution, and thermal lens effect of the Nd:YVO4 thin disk, are presented considering the influence of the energy transfer upconversion effect and the temperature dependence of the thermal conductivity tensor. The simulated results are in good agreement with the experimental results.
Temperature-Sensitive Paint Applications in the Heat Transfer Analysis of 90° Elbow Microchannel Flow with Sharp and Curved Turns
Authors: Huang Chih-Yung , Lin Jhih-Ren , Liou Tong-Miin 
Published: April 2020

ABSTRACTThis study presents the heat transfer analysis of 90° elbow microchannel flow with sharp and curved turn designs. Experimental technique of temperature-sensitive paint was adapted in the experiment for measuring both fluid and surface temperature. The detailed information of fluid and surface temperature data were successfully acquired with a microscope system at Reynolds number varying from 50.5 to 101.1. Micro heaters were fabricated and positioned underneath the microchannel to provide the constant heat flux boundary condition. The utilization of micro heaters can prevent the axial heat conduction. The Nusselt number contours were obtained in this study with sharp and curved corners, which can provide detailed information of localized region with high and low heat transfer. The experimental approach performed in this study could be applied in the future for micro heat exchanger or heat sink design with complex microchannel systems.
English fragments, Minimize Domains, and Minimize Forms
Authors: NYKIEL JOANNA , HAWKINS JOHN A. 
Published: April 2020

ABSTRACTWe offer an account of preposition drop under clausal ellipsis in terms of two language processing principles: Minimize Domains and Minimize Forms. We argue that when Minimize Domains operates within the PP domain, it disfavors preposition drop due to the preferred independent processability of the PP fragment. When it operates within the VP domain it favors preposition drop in proportion to the number and strength of semantic dependencies between V and P in a given language: the more dependencies there are, and the stronger they are, the stronger the preference for preposition drop. In this way fragments are avoided with long dependencies between P and a distant V. We demonstrate this pattern in English corpora and propose it as an explanation for the typologically unusual preference that English shows for NP fragments. Minimize Forms supports preposition drop in easy-to-process environments cross-linguistically and in English when the more minimal fragment (NP) can be easily linked to its correlate in the antecedent, disfavoring preposition drop elsewhere. The predictions of Minimize Domains and Minimize Forms receive support from a mixed-effects regression model fitted to data from spoken US English, and can be understood as motivations for construction-specific constraints and preferences in clausal ellipsis.
Depleted and ultradepleted basalt and picrite in the Davis Strait: Paleocene volcanism associated with a transform continental margin
Authors: Larsen Lotte Melchior , Williamson Marie-Claude 
Published: April 2020

AbstractVolcanic rocks from the Davis Strait were studied to elucidate the tectonomagmatic processes during rifting and the start of seafloor spreading, and the formation of the Ungava transform zone between Canada and Greenland. The rocks are from the wells Hekja O-71, Gjoa G-37, Nukik-2 and Hellefisk-1, and from dredges on the northern Davis Strait High. Ages range from Danian to Thanetian (dinocyst palynozones P2 to P5, 62.5–57.2 Ma). The rocks are predominantly basaltic, but include picrites on the Davis Strait High. Calculated mantle potential temperatures for the Davis Strait High arec.1500°C, suggesting the volume of magma generated was large; this is consistent with geophysical evidence for magmatic underplating in the region. The rare earth element patterns indicate residual mantle lithologies of spinel peridotite and, together with Sr–Nd isotopes, indicate melting beneath regionally extensive, depleted asthenosphere beneath a lithosphere of thickness similar to, or thinner than, beneath Baffin Island and distinctly thinner than beneath West Greenland. Some sites include basalts with more enriched compositions. Depleted and enriched basalts in the Hellefisk well show contemporaneous melting of depleted and enriched mantle components in the asthenosphere. The Hekja and Davis Strait High basalts and picrites have unique, ultradepleted compositions with (La/Sm)N< 0.5, (Tb/Lu)N< 1 and Nb/Zr = 0.013–0.027. We interpret these compositions as a product of the melting regime within the Ungava transform zone, where the melting column would be steep-sided in cross-section and not triangular as expected at normal spreading ridges. Magmatism along the transform stopped when the tectonic regime changed from transtension to transpression during earliest Eocene time.
Histopathologic evaluation of experimental murine neurocysticercosis after treatment with albendazole/nitazoxanide combination
Authors: Sampaio Guilherme A. , Zago Larissa V. , de Lima Nayana F. , Picanço Guaraciara de A. , Lino Júnior Ruy de S. , Vinaud Marina C. 
Published: April 2020

AbstractNeurocysticercosis (NCC) is the most common helminthic brain infection related to epilepsy. Only albendazole (ABZ) and praziquantel are used in its treatment. The development of new therapeutics has been encouraged.Taenia crassicepscysticerci intracranial infection is the experimental model used in NCC studies. This study evaluated the histopathology of the brains of BALB/c mice experimentally infected withT. crassicepscysticerci after the treatment with the ABZ/nitazoxanide (NTZ) combination. Thirty days after the inoculation the mice received an oral single dose of the ABZ/NTZ combination (40 mg kg−1each). The control groups were treated with: NaCl 0.9%; ABZ or NTZ. The histopathologic evaluation of the brains was performed 24 h after treatment. The ABZ treatment induced discrete mononuclear inflammatory infiltration, meningitis, gliosis, hyperaemia and hippocampus compression; moderate ependimitis and oedema. The NTZ treatment induced accentuated inflammatory infiltration, foamy macrophages, ependimitis, choroiditis, gliosis and hyperaemia and moderate oedema. The ABZ/NTZ combination treatment induced a significant decrease in the polymorphonuclear inflammatory infiltration, ependimitis, choroiditis, gliosis, hyperaemia and ventriculomegaly in comparison with the other groups. The cysticerci showed destruction of the tegument not observed in other groups. The ABZ/NTZ combination is efficient as the parasite showed signs of destruction and lower damage to the host's tissue.
Gastrointestinal parasitic infestation in the Rock ptarmiganLagopus mutain the French Alps and French Pyrenees based on long-term sampling (1987–2018)
Authors: Fanelli Angela , Tizzani Paolo , Belleau Eric 
Published: April 2020

AbstractData presented in this work represents the first record of parasites from the Alpine and PyreneanLagopus mutasubspecies, providing valuable information to consider for conservation management. From 1987 to 2018, 207 Rock ptarmigans were collected in the framework of a long-term sanitary monitoring in France. Eight parasites were found in the Alpine Rock ptarmigan, and one in the Pyrenean subspecies. Only two parasites occurred with high prevalence in the Alpine Rock ptarmigan:Capillaria caudinflata(38.9%) andEimeriasp. (34.7%). Prevalence of the other parasites (Ascaridia compar, Cestodes,Amphimerussp. andTrichostrongylus tenuis) was lower than 20%.Dispharynx nasutawas found with a prevalence of 52.9% in the Pyrenean Rock ptarmigan. Overall, we found a spatially aggregated distribution of parasites in the northern French Alps, probably due to both favourable climatic conditions for parasite cycle and high host density. Statistical analyses indicated a positive effect of altitude and latitude onC. caudinflataoccurrence whereas risk factors forEimeriasp. were the distance from urban areas and land cover. In addition, the majority of the infested birds came from areas close to ski-pistes, where human disturbance increases the susceptibility to diseases, causing stress to wildlife.
The DSM-5 proposal for attenuated psychosis syndrome: a history
Authors: Zachar Peter , First Michael B. , Kendler Kenneth S. 
Published: April 2020

AbstractThis article narrates a consensus history of the proposal to include diagnostic criteria for a psychosis risk syndrome in the DSM-5, in part, to document what happened, but also to potentially help focus future efforts at clinically useful early detection. The purpose of diagnosing a risk state would be to slow and ideally prevent the development of the full disorder. Concerns about diagnosing a psychosis risk state included a high false positive rate, potentially harmful use of anti-psychotic medication with people who would not transition to psychosis, and stigmatization. Others argued that educating professionals about what ‘risk’ entails could reduce inappropriate treatments. During the revision, the proposal shifted from diagnosing risk to emphasizing current clinical need associated with attenuated psychotic symptoms. Within the community of researchers who studied psychosis risk, people disagreed about whether risk and/or attenuated symptoms should be an official DSM-5 diagnosis. Once it became clear that the DSM-5 field trials did not include enough cases to establish the reliability of the proposed criteria, everyone agreed that the criteria should be put in a section on conditions for further study rather the main section of the DSM-5. We close with recommendations about some practical benchmarks that should be met for including criteria for early detection in the classification system.
Resource ecologies, political economies and the ethics of audio technologies in the Anthropocene
Authors: Bates Eliot 
Published: April 2020

AbstractUnderstanding how recorded and amplified stage musics contribute towards producing the Anthropocene necessitates attending to complex transnational flows of material, capital and labor, and how they coalesce into technological objects. This is complicated by the wide array of sites, practices and knowledges involved during various stages of the production process, from initial resource extraction, to smelting, component manufacturing, technology assembly, and distribution. To develop a suitable technological ethics, and to understand what happens to environments and to human, animal and plant lifeworlds, requires one to resist abstraction and undertake a global accounting of resource ecologies with recourse to planetary-scale political economy. Towards this goal, I provide a partial account of an early 2000s mic preamp, a mundane but nonetheless fetishised recording studio technological object. I focus on two metals, tin and tantalum, that are primarily extracted for electronics manufacturing, and two building blocks of electronics, solder and capacitors, which are essential for making contemporary electronics.
Time Is Power: Rethinking Meritocratic Political Selection in China
Authors: Zeng Yu , Wong Stan Hok-wui 
Published: April 2020

AbstractWhether local officials in China are promoted on a meritocratic basis has been the subject of long-standing debate. Merit is commonly gauged by a leader's ability to deliver local GDP growth. Although some find economic performance to be a strong predictor of the career success of local leaders, we argue that the existing measure, which focuses on the promotion outcome of a single career step, is problematic because the career success of individual local leaders is seldom determined by a single promotion, or the lack thereof. We propose an alternative measure that is more suitable for China's political context: the length of time until promotion. Analysing the time it takes to gain promotion for four types of local leaders, we find that good economic performance is associated with a shorter time until promotion. However, the cumulative time-reducing effect of economic performance is far from significant, as it is generally insufficient to help local leaders overcome the age ceiling for promotion.
Explaining variations in responsiveness to external pressure: Japan's aid policy and bureaucratic politics
Authors: Iwanami Yukari 
Published: April 2020

AbstractAlthough preceding studies on Japan's foreign aid tend to report that Japan's aid policy is receptive to US pressure, it remains unclear which direction the US wishes Japan to assist its aid programs and how bureaucratic politics of Japan reduces the magnitude of US influence. This paper pursues the first attempt to provide a theoretical framework for the direction of US influence on Japan's aid provision and to explore whether its impact varies across different types of aid. I utilize a new dataset on Japan's Official Development Assistance from 1971 to 2009 and employ both ordinary least squares and two-stage least squares regressions to handle the issues of reverse causality and joint decision-making. The combined results of quantitative and qualitative analyses suggest that the US tends to urge Japan to complement its aid efforts rather than to substitute them as substitution will allow Japan to increase its clout in strategically important recipients and the US attempts to minimize this risk by asking Japan to disburse aid in tandem. I also find that the allocation of Japanese grants is more receptive to US pressure than that of loans because the former is left to the discretion of the Ministry of Foreign Affairs that uses external pressure to win bureaucratic turf wars, whereas loans are determined through consultations among multiple agencies with constituencies that prioritize Japan's domestic interests. The findings are robust across different model specifications and different samples.
TRUTH AND THE GOLDILOCKS PRINCIPLE
Authors: Capps John 
Published: April 2020

AbstractTheories of truth are designed to help us understand this fundamental philosophical concept. But some theories of truth do too little while others do too much. Some theories omit important aspects of truth while other theories place limits on what's true and what we can know. Because theories that do too much can have significant drawbacks I propose what I call the Goldilocks Principle. Theories of truth should not do too much or too little but aim to be just right.
Associations between cognitive performance and Mediterranean dietary pattern in patients with type 1 or type 2 diabetes mellitus
Authors: Kössler Theresa , Weber Katharina S. , Wölwer Wolfgang , Hoyer Annika , Strassburger Klaus , Burkart Volker , Szendroedi Julia , Roden Michael , Müssig Karsten ,   for the GDS Group, Roden M. , Al-Hasani H. , Buyken A. E. , Belgardt B. , Geerling G. , Herder C. , Icks A. , Kotzka J. , Kuß O. , Lammert E. , Hwang J-H. , Müssig K. , Markgraf D. , Rathmann W. , Szendroedi J. , Ziegler D. 
Published: April 2020

AbstractDiabetes mellitus has been associated with impaired cognitive performance, particularly in verbal memory. Mediterranean diets (MedD) may lead to improvements in overall and single cognitive functions. We hypothesised that adherence to MedD associates with better performance in verbal memory in patients with type 1 or type 2 diabetes. Thus, we performed a cross-sectional analysis including patients with recently diagnosed type 1 (n = 75) or type 2 diabetes (n = 118), metabolically healthy individuals (n = 41) and individuals with type 1 (n = 44) or type 2 diabetes (n = 62) of at least five years after diagnosis. Participants underwent comprehensive metabolic phenotyping and cognitive testing. Adherence to the Modified Mediterranean diet scale (MMDS) was computed from a food frequency questionnaire. Among patients with type 2 diabetes with a known diabetes duration ≥5 years, closer adherence to the MMDS was associated with higher score in verbal memory after adjustment for potential confounders (P = 0.043). Adherence to the MMDS did not relate to verbal memory in recently diagnosed type 2 diabetes (P = 0.275), recently diagnosed or longer-standing type 1 diabetes (P = 0.215 andP = 0.626, respectively) or metabolically healthy individuals (P = 0.666). In conclusion, closer adherence to MedD may exert beneficial effects on cognitive performance in the course of type 2 diabetes.
Ki-67 response-guided preoperative chemotherapy for HER2-positive breast cancer: results of a randomised Phase 2 study
Authors: Mukai Hirofumi , Yamaguchi Takeshi , Takahashi Masato , Hozumi Yasuo , Fujisawa Tomomi , Ohsumi Shozo , Akabane Hiromitsu , Nishimura Reiki , Takashima Tsutomu , Park Youngjin , Sagara Yasuaki , Toyama Tatsuya , Imoto Shigeru , Mizuno Toshiro , Yamashita Satoshi , Fujii Satoshi , Uemura Yukari 
Published: April 2020

Abstract
Background
The effectiveness of a therapeutic strategy that switches chemotherapy, based on Ki-67 tumour expression after initial therapy, relative to that of standard chemotherapy, has not been evaluated.

Methods
Patients were randomly assigned to the control arm or the Ki-67 response-guided arm (Ki-67 arm). Primary tumour biopsies were obtained before treatment, and after three once-weekly doses of paclitaxel and trastuzumab to assess the interim Ki-67 index. In the control arm, paclitaxel and trastuzumab were continued for a total of 12 doses, regardless of the interim Ki-67 index. In the Ki-67 arm, subsequent treatment was based on the interim Ki-67 index. Ki-67 early responder is defined as the absolute Ki-67 value that was <10%, and the percentage of Ki-67-positive tumour cells was reduced by >30% compared with before treatment. Early Ki-67 responders continued to receive the same treatment, while early Ki-67 non-responders were switched to epirubicin plus cyclophosphamide. The primary endpoint was the pathological complete response (pCR) rate.

Results
A total of 237 patients were randomised. There was almost linear correlation between the Ki-67 reduction rate at interim assessment and the pCR rate. The pCR rate in Ki-67 early non-responders in the Ki-67 arm was inferior to that in the control arm (44.1%; 31.4–56.7; P = 0.025).

Conclusions
The standard chemotherapy protocol remains as the recommended strategy for patients with HER2-positive breast cancer.

Clinical trial registration
Clinical Trial Registration: UMIN-CTR as UMIN000007074.
The WRKY transcription factor PlWRKY65 enhances the resistance of Paeonia lactiflora (herbaceous peony) to Alternaria tenuissima
Authors: Wang Xue , Li Junjie , Guo Jing , Qiao Qian , Guo Xianfeng , Ma Yan 
Published: April 2020

AbstractIn this study, the disease resistance gene PlWRKY65 was isolated from the leaves of Paeonia lactiflora and analyzed by bioinformatics methods, and the localization of the encoded protein was explored. Quantitative real-time PCR (qRT-PCR) was also used to explore the response of this gene to Alternaria tenuissima. The results showed that the gene sequence contained multiple cis-acting elements involved in the response to hormone signaling molecules belonging to the IIe subgroup of the WRKY family, and the encoded proteins were located in the nucleus. The PlWRKY65 gene has a positive regulatory effect on A. tenuissima infection. After silencing the PlWRKY65 gene via virus-induced gene silencing (VIGS), it was found that the gene-silenced plants were more sensitive to A. tenuissima infection than the wild plants, exhibiting more severe infection symptoms and different degrees of changes in the expression of the pathogenesis-related (PR) genes. In addition, we showed that the endogenous jasmonic acid (JA) content of P. lactiflora was increased in response to A. tenuissima infection, whereas the salicylic acid (SA) content decreased. After PlWRKY65 gene silencing, the levels of the two hormones changed accordingly, indicating that PlWRKY65, acting as a disease resistance-related transcriptional activator, exerts a regulatory effect on JA and SA signals. This study lays the foundation for functional research on WRKY genes in P. lactiflora and for the discovery of candidate disease resistance genes.