bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of a patient with PPP syndrome presenting pancreatic pseudocysts, panniculitis, and symptoms of polyarthritis. A radicular cyst of the upper jaw could be another manifestation of the syndrome
Authors: Konschake Wolfgang , Westphal Thea , Jünger Michael , Arnold Andreas , Lutze Stine 
Published: January 2020

AbstractIn rare cases, pancreatic enzymes can enter the bloodstream and cause fat necrosis in the bone and tissue leading to a disorder called pancreatitis, panniculitis, and polyarthritis syndrome. Clinicians should have this syndrome in mind when treating patients with pancreatitis.
A hidden cause of infertility in hypothyroid patients
Authors: Allam Magdy Mohamed , El‐Zawawy Hanaa Tarek , Barakat Sherine Samir , Ahmed Soha Magdy , Saleh Rasha Noureldin M. 
Published: January 2020

AbstractMethylene tetrahydrofolate reductase (MTHFR) gene mutations could be the cause of infertility in hypothyroid patients. Hence, it is worthy to screen for MTHFR gene mutations in infertile hypothyroid females and their partners if infertility persists after optimizing thyroid function.
Biventricular hypertrabeculations or noncompaction in a 54‐year‐old woman in Sub‐Saharan Africa: A case report
Authors: Jingi Ahmadou Musa , Mfeukeu‐Kuate Liliane , Amougou Sylvie Ndongo , Boombhi Jerome , Hakapoka Herbert , Mintom Pierre , Wawo‐Guela Edvine , Hamadou Ba 
Published: January 2020

AbstractVentricular noncompaction or hypertrabeculation is rare and unclassified cardiomyopathy that mostly affects the left ventricle. We report the case of biventricular hypertrabeculation in a 54‐year‐old woman who presented with congestive heart failure de novo associated with arrhythmia in a low‐income setting. We also discussed the therapeutic challenges.
Rational Stepwise Construction of Different Heterometallic–Organic Frameworks (HMOFs) for Highly Efficient CO2 Conversion
Authors: Liu Jiao , Wu Dan , Yang Guo‐Ping , Wu Yunlong , Zhang Shuyu , Jin Jing , Wang Yao‐Yu 
Published: January 2020

AbstractThe coordination preference of different metal ions and ligands have an immense influence on the constructions of functional MOF materials. In this work, two new monometallic complexes, namely [Ag(HL)(bipy)0.5] (1) and {[Tb(L)1.5(H2O)]⋅4 H2O}n (2) (bipy=4,4‐bipyridine), have been synthesized successfully by employing a bifunctional 2‐(imidazol‐1‐yl)terephthalic acid (H2L) ligand. After that, two new different heterometallic–organic frameworks (HMOFs), namely {[TbAg(L)2(H2O)3]⋅H2O}n (3) and [TbAg(L)2(H2O)]n (4), were obtained from complexes 1 and 2 as the precursors based on a rational stepwise construction strategy and the theory of hard and soft acids and bases (HSAB principle), respectively. The HMOFs bearing dual metallic catalytic sites (Tb and Ag) can be used as heterogeneous catalysts without losing performance for the chemical fixation of CO2 with epoxides including the sterically hindered epoxides, demonstrating some of the highest reported catalytic activity values. This work may provide a new synthetic route toward tailoring new HMOFs with excellent catalytic activity.
Borosulfates—Synthesis and Structural Chemistry of Silicate Analogue Compounds
Authors: Bruns Jörn , Höppe Henning A. , Daub Michael , Hillebrecht Harald , Huppertz Hubert 
Published: January 2020

AbstractBorosulfates are oxoanionic compounds consisting of condensed sulfur‐ and boron‐centered tetrahedra. Hitherto, they were mostly achieved from solvothermal syntheses in SO3‐enriched sulfuric acid, or from reactions with the superacid H[B(HSO4)4]. The crystal structures are very similar to those of the corresponding class of silicates and their substitution variants, especially regarding the typical structural motif of corner‐sharing tetrahedra. However, the borosulfates are supposed to be even more versatile, because (BO3) units might also be part of the anionic network. The following article deals with detailed reports on the different synthesis strategies, the crystal chemistry of borosulfates in comparison to silicates, and their hitherto identified properties.
Ruthenium‐Induced Cyclization of Heteroatom‐Functionalized Alkynes: Progress, Challenges and Perspectives
Authors: Chung Lai‐Hon , Yeung Chi‐Fung , Wong Chun‐Yuen 
Published: January 2020

AbstractMetal‐induced cyclization of functionalized alkynes represents one of the most general approaches to prepare organic heterocycles. Although RuII centers are well‐established to promote alkyne to vinylidene rearrangements and many RuII‐mediated alkyne cyclizations have been rationalized to be the results of post‐vinylidene transformations, recent discoveries indicate that RuII centers can serve as electrophiles and induce alkyne cyclizations without vinylidene intermediacy. In this Minireview, an overview of the RuII‐induced cyclization of heteroatom‐functionalized alkynes in the last decade is provided, with an emphasis on the discoveries and validations of the unconventional “non‐vinylidene‐involving” pathways.
Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I‐NBOMe
Authors: Garrido Eva , Alfonso María , Díaz de Greñu Borja , Lozano‐Torres Beatriz , Parra Margarita , Gaviña Pablo , Marcos M. Dolores , Martínez‐Máñez Ramón , Sancenón Félix 
Published: January 2020

AbstractThis work reports the synthesis, characterization, and sensing behavior of a hybrid nanodevice for the detection of the potent abuse drug 25I‐NBOMe. The system is based on mesoporous silica nanoparticles, loaded with a fluorescent dye, functionalized with a serotonin derivative and capped with the 5‐HT2A receptor antibody. In the presence of 25I‐NBOMe the capping antibody is displaced, leading to pore opening and rhodamine B release. This delivery was ascribed to 5‐HT2A receptor antibody detachment from the surface due to its stronger coordination with 25I‐NBOMe present in the solution. The prepared nanodevice allowed the sensitive (limit of detection of 0.6 μm) and selective recognition of the 25I‐NBOMe drug (cocaine, heroin, mescaline, lysergic acid diethylamide, MDMA, and morphine were unable to induce pore opening and rhodamine B release). This nanodevice acts as a highly sensitive and selective fluorometric probe for the 25I‐NBOMe illicit drug in artificial saliva and in sweets.
Challenges and Opportunities in the Production of Oxymethylene Dimethylether
Authors: Gierlich Christian Henning , Beydoun Kassem , Klankermayer Jürgen , Palkovits Regina 
Published: January 2020

AbstractTo reduce the NOx and soot emissions of conventional diesel fuels, different renewable alternatives are investigated. One example are oxymethylene ethers (OMEx) of different chain lengths, which are intended to be used as diesel blends. Especially OME3–5 show properties comparable to diesel. The key to producing longer chain OMEs is OME1 as feedstock, which can react with formaldehyde to afford larger molecules. This article reviews different synthesis routes for OME1, in order to elucidate energy‐efficient methods.
Grouping multi‐rate sampling fault detection method for penicillin fermentation process
Authors: Li Keqin , Feng Jian 
Published: January 2020

AbstractFor the multi‐rate sampling problem of the penicillin fermentation process, some traditional methods cannot be solved due to the different lengths of samples. To solve this problem, a grouping multi‐rate sampling fault detection method is proposed. The training sample set is divided into multiple groups according to different sampling rates of variables. Each group has the same sample length. We use the principle component analysis and k‐nearest neighbour methods to build model for every group. Then the models of all groups are combined to determine the control limit. The PenSim2.0 software is used to generate a sample set of the penicillin fermentation process that contained multiple variables at different sampling rates. The simulation result shows the effectiveness of the proposed method.
Clustering of cutaneous T‐cell lymphoma is associated with increased levels of the environmental toxins benzene and trichloroethylene in the state of Georgia
Authors: Clough Lindsay , Bayakly A. Rana , Ward Kevin C. , Khan Mohammad K. , Chen Suephy C. , Lechowicz Mary Jo , Flowers Christopher R. , Allen Pamela B. , Switchenko Jeffrey M. 
Published: January 2020

BackgroundCutaneous T‐cell lymphoma (CTCL) is a rare form of non‐Hodgkin lymphoma arising in the skin. Geographic clustering of CTCL has recently been reported, but its association with environmental factors is unknown. Benzene and trichloroethylene (TCE) are environmental toxins with carcinogenic properties. The authors investigated associations between geographic clustering of CTCL incidence in the state of Georgia with benzene and TCE exposure.MethodsThe statewide county‐level incidence of CTCL within Georgia was obtained from the Georgia Cancer Registry for the years 1999 to 2015. Standardized incidence ratios (SIRs) were calculated by dividing observed cases by expected cases using national incidence rates by age, sex, and race. Clustering of CTCL was analyzed using spatial analyses. County‐level concentrations of benzene and TCE between 1996 and 2014 were collected from the Environmental Protection Agency's National Air Toxics Assessment database. Linear regression analyses on CTCL incidence were performed comparing SIRs with levels of benzene and TCE by county.ResultsThere was significant geographic clustering of CTCL in Georgia, particularly around Atlanta, which was correlated with an increased concentration of benzene and TCE exposure. Among the 4 most populous counties in Georgia, CTCL incidence was between 1.2 and 1.9 times higher than the state average, and benzene and TCE levels were between 2.9 and 8.8 times higher.ConclusionsThe current results demonstrate nonrandom geographic clustering of CTCL incidence in Georgia. To the authors' knowledge, this is the first analysis to identify a correlation between geographic clustering of CTCL and environmental toxic exposures.
Quantitative trait loci sequencing–derived molecular markers for selection of stem rot resistance in peanut
Authors: Cui Renjie , Clevenger Josh , Chu Ye , Brenneman Timothy , Isleib Thomas G. , Holbrook C. Corley , Ozias‐Akins Peggy 
Published: January 2020

AbstractDeveloping markers linked to key traits has been a focus of peanut (Arachis hypogaea L.) genomics in the postgenome era. Multiple disease resistance traits have been found to be qualitative and controlled by major quantitative trait loci (QTL) or even single genes while others are more complex. Southern stem rot (stem rot in short) is a devastating disease of peanut caused by the fungus Sclerotium rolfsii. It has been one of the most damaging diseases of peanut with regard to both cost of control and yield loss in the southeastern United States for the last decade. The disease is initiated annually from sclerotia in the soil. The nonuniform distribution of these propagules leads to the nonuniform development of disease, which makes phenotyping and genetic mapping of resistance difficult. Here we report the mapping of two QTL regions controlling stem rot resistance in peanut. Using careful field evaluation, resistant and susceptible bulks were identified from a recombinant inbred line (RIL) population and subjected to QTL sequencing (QTL‐seq). Developed SNP markers linked to the QTL were validated in a blind selection test by selecting only with markers in a part of the population not used for initial analysis. The lines selected for bulk sequencing also were shown to have strong separation for resistance in an independent field experiment. This work not only delivers markers for marker‐assisted selection (MAS) for an important disease in peanut but shows that QTL‐seq can work effectively even when considering highly complex, and quantitative traits.
Recent Advances of Two‐Dimensional Nanomaterials for Electrochemical Capacitors
Authors: Huang Tingting , Jiang Yuan , Shen Guozhen , Chen Di 
Published: January 2020

AbstractTwo‐dimensional (2D) nanomaterials have drawn a wide range of research interests because of their unique ultrathin layered structures and attractive properties. In particular, the electrochemical properties and great variety of 2D nanomaterials make them highly attractive candidates for electrochemical capacitors, such as supercapacitors, lithium‐ion capacitors, and sodium‐ion capacitors. Herein, a comprehensive review of recent progress towards the application of 2D nanomaterials for electrochemical capacitors is provided. Several typical types of 2D nanomaterials are first briefly introduced, followed by detailed descriptions of their electrochemical capacitor applications. Finally, research perspectives and future research directions of these interesting areas are also provided.
Selected pharmacotherapy agents as antiproliferative and anti‐inflammatory compounds
Authors: AlKhalil Mthanna , Al‐Hiari Yusuf , Kasabri Violet , Arabiyat Shereen , Al‐Zweiri Muhammad , Mamdooh Noor , Telfah Ahmad 
Published: January 2020

AbstractThe repurposing of safe therapeutic drugs has emerged as an alternative approach to rapidly identify effective, safe, and conveniently available therapeutics to treat/prevent cancer. Therefore, it was hypothesized that acidic chelator drugs could have a genuine potential as antiproliferative agents. Based on their pKa, the selected 15 acidic drugs of eight classes—namely sulfonylureas, proton pump inhibitors, fluoroquinolones, nonsteroidal anti‐inflammatory agents, thiazolidinediones, thienopyridines, statins, and nicotinic acid—were assayed for anticancer HTS against the lung A549, skin A375, breast MCF7 and T47D, pancreatic PANC1, cervical HeLa, and leukemia K562 cancer cell lines and normal fibroblasts. Lipopolysaccharide‐prompted inflammation in RAW264.7 macrophages was the potential anticancer mechanism. Atorvastatin exerted remarkably superior cytotoxicity against A375.2S (IC50 value 0.02 μM p < .001 vs. cisplatin 0.07 μM IC50 value). Atorvastatin exhibited an equipotency to cisplatin's T47D growth inhibition (34.6 μM vs. 34.59 μM; p > .05). Levofloxacin as well as ciprofloxacin superbly superseded the antineoplastic cisplatin activity against the K562 cell line (respective IC50 values [μM] 10.4 and 19.5 vs. 29.3; p < .05–<.01). Gemifloxacin and lansoprazole had comparable antiproliferation in K562 to cisplatin's (respective IC50 values [μM] 34.9 and 36.3 vs. 29.3; p > .05). The selected agents lacked cytotoxicity in the panel of MCF7, HeLa, A549, or Panc1 cancer cells. Most notably, LPS prompted RAW264.7 macrophages, atorvastatin, piroxicam, clopidogrel, esomeprazole, and lansoprazole were of higher anti‐inflammation potency than indomethacin (p < .01–.001). Evidently, omeprazole, pioglitazone, gemifloxacin, and indomethacin were of comparable anti‐inflammation potencies (p > .05). Collectively, this work reveals acidic chelator drugs (atorvastatin, gemifloxacin, and lansoprazole with dual anti‐inflammation and antiproliferation propensities) as authentic agents for the repurposing approach in anticancer chemotherapy/prevention.
Development of a Molecularly Imprinted Poly(Acrylic Acid)‐MWCNT Nanocomposite Electrochemical Sensor for Tramadol Determination in Pharmaceutical Samples
Authors: Ricardo Teixeira Tarley César , de Cássia Mendonça Jhessica , Rianne da Rocha Luana , Boareto Capelari Tainara , Carolyne Prete Maiyara , Cecílio Fonseca Matheus , Midori de Oliveira Fernanda , César Pereira Arnaldo , Luiz Scheel Guilherme , Bastos Borges Keyller , Gava Segatelli Mariana 
Published: January 2020

AbstractA new voltammetric sensor based on molecularly imprinted poly(acrylic acid)‐MWCNT nanocomposite (MIP‐MWCNT) drop‐coated onto glassy carbon electrode (GCE) was developed and applied to tramadol (TR) determination in pharmaceutical samples. The voltammetric sensor prepared by suspension of MIP‐MWCNT at 1 : 1 (w/w) ratio show an improved performance compared to unmodified GCE. The electrochemical method is based on preconcentration of tramadol onto MIP‐MWCNT modified GCE surface at −1.5 V vs Ag/AgCl for 180 s in 0.1 Britton‐Robinson buffer (pH 8.0) at stirred solution. Upon preconcentration, the differential anodic voltammogram was recorded under the optimized condition giving rise to an analytical curve varying from 9.0 up to 30.0 μmol L−1 (R2=0.997) and limits of detection and quantification of 1.4 and 4.8 μmol L−1, respectively. The method precision was assessed in terms of intraday (n=6) and interday (two consecutive days) precision, giving relative standard deviations (RSD%) values between 2.8 to 7.4 %. Excipients usually found in pharmaceutical pills (magnesium stearate, microcrystalline cellulose, starch, and silica) and paracetamol were evaluated as potential interferents, however no interference was evidenced in TR determination. The method applicability was evaluated by TR analysis in pharmaceutical samples. Moreover, the method accuracy was attested by comparison of addition and recovery assays with a reference technique (high‐performance liquid chromatography).
A reconstructed discontinuous Galerkin method for multi‐material hydrodynamics with sharp interfaces
Authors: Pandare Aditya K. , Waltz Jacob , Bakosi Jozsef 
Published: January 2020

SummaryDiscontinuous Galerkin (DG) methods have been well established for single‐material hydrodynamics. However, consistent DG discretizations for non‐equilibrium multi‐material (more than two materials) hydrodynamics have not been extensively studied. In this work, a novel reconstructed DG (rDG) method for the single‐velocity multi‐material system is presented. The multi‐material system being considered assumes stiff velocity relaxation, but does not assume pressure and temperature equilibrium between the multiple materials. A second‐order DG(P1) method and a third‐order least‐squares based rDG(P1P2) are used to discretize this system in space, and a third‐order total variation diminishing (TVD) Runge‐Kutta method is used to integrate in time. A well‐balanced DG discretization of the non‐conservative system is presented and is verified by numerical test problems. Furthermore, a consistent interface treatment is implemented, which ensures strict conservation of material masses and total energy. Numerical tests indicate that the DG and rDG methods are, indeed, the second‐ and third‐order accurate. Comparisons with the second‐order finite volume method show that the DG and rDG methods are able to capture the interfaces more sharply. The DG and rDG methods are also more accurate in the single‐material regions of the flow. This work focuses on the general multidimensional rDG formulation of the non‐equilibrium multi‐material system and a study of properties of the method via one‐dimensional numerical experiments. The results from this research will be the foundation for a multidimensional high‐order rDG method for multi‐material hydrodynamics.
Influence of E‐beam irradiation on microbiological and physicochemical properties and fatty acid profile of frozen duck meat
Authors: Arshad Muhammad Sajid , Kwon Joong‐Ho , Ahmad Rabia Shabir , Ameer Kashif , Ahmad Sheraz , Jo Yunhee 
Published: January 2020

AbstractThis study investigated the effect of different doses (0, 3, and 7 kGy) of e‐beam on the microbiological and physicochemical qualities and the profile of fatty acids of the frozen duck meat (FDM). Electron beam at the dose of 3 kGy showed more than 2 log and 1 log cycles of reduction in the total bacterial (TAB) and coliform counts (TCC), respectively. The results indicated an increase in the TBARS values (1.50 ± 0.02 mg MDA/kg), peroxide value (0.83 ± 0.04 meq peroxide/kg), and total volatile base nitrogen (1.31 ± 0.16 mg/100 ml), but no effect on the sensory parameters. Irradiation lowered the lightness (L*) (31.87 ± 0.98) and redness (a*) (11.04 ± 0.20) values but elevated the metmyoglobin content in FDM. In addition, irradiation had no effect on the benzopyrene content; however, a reduction was observed in the vitamin A (0.239 ± 0.015 µg/g) and vitamin E (1.847 ± 0.075 µg/g) contents of the FDM samples. There were no trans‐fatty acids present in the treated (irradiated) as well as the untreated (nonirradiated) meat samples (FDM), whereas the fatty acid content decreased in irradiated samples, in contrast with the nonirradiated control. Electronic nose clearly discriminated between the nonirradiated and irradiated FDM based on principal component analysis. It is concluded that the e‐beam successfully improved the microbial quality of FDM with slight changes in physicochemical properties, but without altering its sensory properties.
Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats
Authors: Wei Qi , Li Jie , Zhan Yishu , Zhong Qiangui , Xie Baogui , Chen Lei , Chen Bingzhi , Jiang Yuji 
Published: January 2020

AbstractAgaricus blazei Murrill (ABM) is an edible fungus. This study investigated the protective role of ABM fruiting body against streptozotocin (STZ)‐induced diabetic rats. After 4 weeks of ABM supplement, glucose homeostasis was improved in diabetic rats. Quantitative real‐time and Western blot analyses suggested that ABM could promote the gene and protein expression level of insulin receptor, pyruvate dehydrogenase kinase, phospho‐kinase B, kinase B, phosphatidylinositol 3‐kinase, insulin receptor substrate 1, glucose transporter‐4, and glutamine synthetase, while inhibiting the expression of glycogen synthase kinase 3β and c‐jun N‐terminal kinase 1 and 2. According to multivariate and univariate statistical analysis, liver metabolite profiles of the normal and diabetic rats fed basal and experimental diet were clearly separated. The differential liver metabolites from diabetic rats fed basal and ABM diet‐related pathways including the glycolysis pathway, pentose phosphate pathway, tricarboxylic acid cycle, and oxidative phosphorylation were analyzed. A total of 18 potential biomarker metabolites were identified as differential biomarkers associated with ABM supplement diet.
Hepatitis C Virus Prevalence in 50 U.S. States and D.C. by Sex, Birth Cohort, and Race: 2013‐2016
Authors: Bradley Heather , Hall Eric W. , Rosenthal Elizabeth M. , Sullivan Patrick S. , Ryerson A. Blythe , Rosenberg Eli S. 
Published: January 2020

Hepatitis C virus (HCV) infection is a leading cause of liver‐related morbidity and mortality, and more than 2 million adults in the United States are estimated to be currently infected. Reducing HCV burden will require an understanding of demographic disparities and targeted efforts to reduce prevalence in populations with disproportionate disease rates. We modeled state‐level estimates of hepatitis C prevalence among U.S. adults by sex, birth cohort, and race during 2013‐2016. National Health and Nutrition Examination Survey data were used in combination with state‐level HCV‐related and narcotic overdose–related mortality data from the National Vital Statistics System and estimates from external literature review on populations not sampled in the National Health and Nutrition Examination Survey. Nationally, estimated hepatitis C prevalence was 1.3% among males and 0.6% among females (prevalence ratio [PR] = 2.3). Among persons born during 1945 to 1969, prevalence was 1.6% compared with 0.5% among persons born after 1969 (PR = 3.2). Among persons born during 1945 to 1969, prevalence ranged from 0.7% in North Dakota to 3.6% in Oklahoma and 6.8% in the District of Columbia. Among persons born after 1969, prevalence was more than twice as high in Kentucky, New Mexico, Oklahoma, and West Virginia compared with the national average. Hepatitis C prevalence was 1.8% among non‐Hispanic black persons and 0.8% among persons of other races (PR = 2.2), and the magnitude of this disparity varied widely across jurisdictions (PR range: 1.3‐7.8). Overall, 23% of prevalent HCV infections occurred among non‐Hispanic black persons, whereas 12% of the population was represented by this racial group. These estimates provide information on prevalent HCV infections that jurisdictions can use for understanding and monitoring local disease patterns and racial disparities in burden of disease.