bluuebunny/crossref_metadata_2025_split huggingface dataset:
Handling effective communication to support awareness in rescue operations
Authors: Chehade Samer , Matta Nada , Pothin Jean‐Baptiste , Cogranne Remi 
Published: September 2020

AbstractEfficient rescue operations require a high level of situation awareness amongst decision‐makers and first responders for the purpose of achieving operations successfully and reducing losses. Moreover, a common operational picture between involved actors is required in order to support decision‐making. Therefore, different organisations and agencies have to collaborate, cooperate, and coordinate their actions with each other. Hence, effective interactions and communications between participants are vital to fulfil these essential needs. However, emergency actors still lack backing to exchange information effectively and ensure a common operational picture in order to reach shared situational awareness. For this reason, we aim to develop and implement Rescue MODES, a communication system oriented to support situation awareness amongst French emergency actors in rescue operations. In this paper, we examine and analyse actors’ activities and interactions, so that the system will be based on the real needs of actors. We start by studying and modelling the communications, interactions, and information flow. This modelling is based on an application ontology. Then, we define requirements for good communication in these operations and present some existing systems in France and how each system responds to these requirements.
Genome‐wide identification and characterization of long non‐coding RNAs in Tribolium castaneum
Authors: Yang Liu , Wang You‐Wei , Lu Yao‐Yao , Li Bin , Chen Ke‐Ping , Li Cheng‐Jun 
Published: September 2020

AbstractLong non‐coding RNAs (lncRNAs) are poorly understood in insects. In this study, we performed genome‐wide analysis of lncRNAs in Tribolium castaneum by RNA‐seq. In total, 4516 lncRNA transcripts corresponding to 3917 genes were identified from late embryos, early larvae, late larvae, early pupae, late pupae and early adults of T. castaneum, including 3152 novel lncRNAs and 1364 known lncRNAs. These lncRNAs have few exons and transcripts, and are short in length. During development, they exhibited nine different expression patterns. Functionally, they can act either by targeting messenger RNAs (1813 lncRNAs) and lncRNAs (45 lncRNAs) or as micro RNA (miRNA) precursors (46 lncRNAs). LncRNAs were observed to target the metabolic enzymes of glycolysis, TCA cycle and amino acids, demonstrating that lncRNAs control metabolism by regulating metabolic enzymes. Moreover, lncRNAs were shown to participate in cell differentiation and development via their targets. As miRNA precursors, lncRNAs could participate in the ecdysone signaling pathway. This study provides comprehensive information for lncRNAs of T. castaneum, and will promote functional analysis and target identification of lncRNAs in the insect.
Genetic diversity, phylogenetic position and morphometric analysis of Astacus colchicus (Decapoda, Astacidae): a new insight into Eastern European crayfish fauna
Authors: BLÁHA Martin , PATOKA Jiří , JAPOSHVILI Bella , LET Marek , BUŘIČ Miloš , KOUBA Antonín , MUMLADZE Levan 
Published: September 2020

AbstractThe phylogeny of European crayfish fauna, especially with respect to Eastern European species, is still far from being completely resolved. To fill this gap, we analyzed most of the European crayfish species focusing on the phylogenetic position of the endemic crayfish Astacus colchicus, inhabiting Georgia. Three mitochondrial and one nuclear marker were used to study evolutionary relationships among European crayfish species, resulting in the unique phylogenetic position of A. colchicus indicating independent species status to A. astacus. Phylogenetic analyses revealed a deep molecular divergence of A. colchicus in comparison to A. astacus (6.5–10.9% in mtDNA and 1.1% in nDNA) as well as to Pontastacus leptodactylus and P. pachypus (5.5–10.0% in mtDNA and 1.4–2.4% in nDNA). Absent ventral process on second male pleopod and abdominal somites II and III with pleura rounded lacking prominent spines clearly indicate taxonomic assignment to the genus Astacus; however, the species is distributed almost in the middle of Ponto‐Caspian area typical by occurrence of the genus Pontastacus. Several morphological indices linked to head length, carapace, and total body length and width were found to demonstrate apparent differences between A. colchicus and A. astacus. Although this study provides a novel insight into European crayfish phylogeography, we also point out the gaps in comprehensive study of the P. leptodactylus species complex, which could reveal details about the potential species status of particular species and subspecies within this genus.
Androgen receptor DNA methylation is an independent determinant of glucose metabolic disorders in women; testosterone plays a moderating effect
Authors: Liu Xue , Huo Wenqian , Zhang Rui , Wei Dandan , Tu Runqi , Luo Zhicheng , Wang Yan , Dong Xiaokang , Qiao Dou , Liu Pengling , Zhang Li , Fan Keliang , Nie Luting , Liu Xiaotian , Li Linlin , Wang Chongjian , Mao Zhenxing 
Published: September 2020

AbstractBackgroundWe have previously shown that serum testosterone was associated with impaired fasting glucose (IFG) and type 2 diabetes (T2D). Testosterone can be acting through binding the androgen receptor (AR). Therefore, we aimed to explore the independent associations of AR DNA methylation (ARm) with IFG and T2D and the moderation effects of serum testosterone on the associations.MethodsA case‐control study with 1065 participants including 461 men and 604 women was performed. ARm in peripheral blood sample and serum testosterone were measured using pyrosequeuncing and liquid chromatography‐tandem mass, respectively. Multivariable logistic regression was performed to estimate the associations of ARm (including 2 cytosine‐phosphoguanine [CpG] islands and average methylation levels) with different glucose status. Serum testosterone was used as a moderator to estimate the moderation effect.ResultsAfter multivariate adjustment, CpG 1, 2 and CpG average methylation were all significantly associated with IFG (CpG 1: Odds ratio (OR) = 4.80, 95% confidence interval (CI): 2.24‐10.27; CpG 2: OR = 4.35, 95% CI: 2.50‐7.58; CpG average: OR = 11.73, 95% CI: 5.36‐25.67) in women. In addition, testosterone played negative moderation effects in above associations. Moreover, no significant independent associations of methylation levels with T2D was observed both in men and women.ConclusionOur findings demonstrate that ARm was positively associated with IFG in women and the associations would be weakened by testosterone. The individuals experiencing low testosterone and ARm levels reported a lower state of IFG than those who experienced high levels of testosterone and ARm in women.
Cost–utility analysis of adjuvant chemotherapy after concurrent chemoradiation in patients with locally advanced cervical cancer
Authors: Rongsriyam Kanisa , Tangjitgamol Siriwan , Leelahavarong Pattara , Teerawattananon Yot , Tharavichitkul Ekkasit , Tovanabutra Chokaew , Asakij Tussawan , Paengchit Kannika , Sukhaboon Jirasak , Penpattanagul Somkit , Kridakara Lieutenant Col. Apiradee , hanprasertpong Jitti , Khunnarong Jakkapan , Chottetanaprasith Taywin , Lorvidhaya Vichan 
Published: September 2020

AbstractIntroductionThis study aimed to compare the cost utility of concurrent chemoradiation (CCRT) to CCRT followed by adjuvant chemotherapy (CCRT/ACT) in locally advanced cervical cancer (LACC) using provider and societal viewpoints.MethodsData from our trial which was a multi‐centre study evaluating the efficacy of ACT compared to CCRT/ACT were entered into a decision tree model. The data included clinical probability, direct medical and non‐medical costs, and utility obtained from the patients. The total cost, quality‐adjusted life‐years (QALYs) and incremental cost‐effectiveness ratios (ICER) were estimated for a time horizon of 3 years. All costs and outcomes were discounted at 3% annually.ResultsThe cost of CCRT and CCRT/ACT was approximately 3,058 and 6,896 USD and 4,309 and 7,480 USD from provider and from societal viewpoints, respectively. The QALYs for CCRT and CCRT/ACT were 2.31480 and 2.32045, respectively. The ICER was 569,575 USD per QALY. For stage III–IVA LACC, the ICER was 28,050 USD per QALY. In the sensitivity analysis, the cost of ACT was the most significant influential parameter on the ICER. The ICER would be 0.26‐fold lower if the cost of ACT was reduced by 25%. At the current ceiling threshold of 5,000 USD/QALY, CCRT had a 100% probability of being the best option.ConclusionsIn the Thai context, CCRT is more cost effective than CCRT/ACT for stage IIB–IVA LACC. CCRT/ACT may be considered only for stage III–IVA LACC because it has a lower ICER than other types of LACC.
A rare case of transient duodenal volvulus in an elderly patient
Authors: Gavin Dominic J , Wilkie Bruce D , Ali Nadira 
Published: September 2020

SummaryDuodenal volvulus is an extremely rare condition, with few cases reported in the literature. We present the case of an 83‐year‐old man with spontaneous duodenal volvulus diagnosed on CT imaging. Findings included volvulus of the third part of the duodenum, the characteristic whirl pattern of the superior mesenteric vessels and medialisation of the gallbladder. He was treated with nasogastric tube decompression and follow‐up CT demonstrated complete resolution of the volvulus.
Sarcopenia in rheumatoid arthritis: Is it a common manifestation?
Authors: Tekgoz Emre , Colak Seda , Ozalp Ates Funda Seher , Sonaeren Ilknur , Yilmaz Sedat , Cinar Muhammet 
Published: September 2020

AbstractObjectiveTo evaluate the presence of sarcopenia in patients with rheumatoid arthritis (RA).MethodThis cross‐sectional study included 100 patients with RA and 100 gender‐matched healthy individuals. Sarcopenia was assessed by performing tests evaluating muscle strength, muscle mass, and physical performance, using the criteria determined by The European Working Group on Sarcopenia. Sarcopenia is defined as a decrease in muscle strength and muscle mass. On the other hand, presarcopenia is defined as a decrease in muscle strength with a normal muscle mass.ResultsThe participants comprised of 70 females and 30 males. The frequency of presarcopenia was 35% in the RA group and 9% in the control group (P < .001). Results of handgrip and gait speed tests were lower in the RA group than in the healthy control group (P = .002 and P < .001, respectively). Presarcopenia was seen at higher rates among female and older patients, and patients with longer disease duration. Disease activity scores were higher in patients with presarcopenia than in patients without sarcopenia (P < .05). In multivariate regression analysis for presarcopenia; a statistically significant association was found between handgrip test results and age, gender, and disease activity (P < .001, R2 = .62).ConclusionsLonger disease duration and higher disease activity may provoke the development of sarcopenia due to chronic inflammation in patients with RA. Physicians should be aware of the development of sarcopenia during the course of disease and take into account the preservative and preventive methods against sarcopenia by encouraging them about exercise along with controlling disease activity.
Prior statin therapy and 30‐day mortality in South Korean patients with acute respiratory distress syndrome
Authors: Oh Tak Kyu , Song In‐Ae 
Published: September 2020

BackgroundThe effect of prior statin therapy on mortality in patients with acute respiratory distress syndrome (ARDS) remains controversial. This study aimed to investigate whether prior statin therapy was associated with lower 30‐day mortality compared to non‐statin use.MethodsThis population‐based cohort study used nationwide data procured from the National Health Insurance service in South Korea, and included all the adult patients admitted to a hospital for ARDS treatment between January 1, 2013 and December 31, 2017.ResultsIn total, 14,600 patients with ARDS were included: 4,319 were statin users and 10,281 were non‐statin users. After propensity score matching, 6,046 patients with ARDS (3,023 patients in each group) were included in the analysis. The 30‐day mortality of statin users was 44.4% (1,331 of 3,023), while that of non‐statin users was 45.2% (1,331 of 3,023). On Cox regression analysis in the propensity score matched cohort, 30‐day mortality was not significantly associated with statin use compared to non‐statin use (hazard ratio: 0.95, 95% confidence interval: 0.88 to 1.02; P = .165). On Kaplan‐Meier estimation, the median survival time in statin users was 45 days (95% CI: 39 to 50), while that in non‐statin users was 42 days (95% CI: 37 to 47) after propensity score matching, and there was no statistical difference with the log‐rank test (P = .215).ConclusionThis population‐based cohort study in South Korea showed that prior statin therapy was not significantly associated with 30‐day mortality in patients with ARDS. Our findings should be confirmed in future prospective studies.
Non‐suicidal self‐injury and its co‐occurrence with suicidal behavior: An epidemiological‐study among adolescents and young adults
Authors: Voss C. , Hoyer J. , Venz J. , Pieper L. , Beesdo‐Baum K. 
Published: September 2020

ObjectiveNon‐suicidal self‐injury (NSSI) comprising thoughts and behaviors is common and often co‐occurring with suicidal behavior like ideation, plan, and attempt. As limited data are available for adolescents and young adults, this study aims to present prevalence estimates for lifetime NSSI, its co‐occurrence with suicidal behavior, conditional probabilities and their association with socio‐demographic characteristics, severity characteristics of suicidal behavior, and health service utilization.MethodThe epidemiological Behavior and Mind Health (BeMIND) study assessed in 2015/16 a random‐community sample of N = 1180 aged 14–21 years from Dresden, Germany, regarding lifetime NSSI via self‐administered questionnaire and suicidal behaviors via standardized interview.ResultsAny lifetime NSSI was reported by 19.3% (thoughts: 18.0%, behaviors: 13.6%) of the sample with higher prevalence in females (OR = 2.7, 95% CI 1.9–3.8, P < 0.001). Lifetime prevalence of co‐occurring NSSI and suicidal behavior was 7.7%. Females had a 3.3‐ to 8.8‐fold odds of co‐occurrence than males. Among those with any NSSI, 39.6% endorsed suicidal behavior, and 66.3% of those with any suicidal behavior reported NSSI. 42.3% of those with any NSSI reported to have used mental healthcare services at any time during their life with higher rates in those with co‐occurring suicidal behavior (62.3%).ConclusionNon‐suicidal self‐injury and co‐occurring suicidal behavior is common in adolescents and young adults—especially females. The limited utilization of mental healthcare services underpins the need for improving recognition of NSSI and suicidal behavior as well as the accessibility of mental healthcare services during adolescence and emerging adulthood.
Trends in epidemiology, treatment and molecular testing of metastatic colorectal cancer in a real‐world multi‐institution cohort study
Authors: Kuchel Anna , Ahern Elizabeth , Collins Stephanie , Whitehall Vicki , Okano Satomi , Pelecanos Anita , Wyld David , Eastgate Melissa , Burge Matthew 
Published: September 2020

AbstractAimColorectal cancer (CRC) is the third most common cancer in Australia, and survival after diagnosis of metastatic disease is improving. Our aim was to assess trends in epidemiology, treatment, molecular testing and survival in patients with metastatic CRC (mCRC).MethodsClinical data from February 2013 to December 2018 was recorded in a prospective, observational, multicenter cohort study conducted in Queensland, Australia, examining clinical and molecular biomarkers in cases of mCRC.ResultsA total of 159 patients who had metastasis diagnosed after February 2013 were included in survival analysis. Median age at diagnosis was 63.9 years, but 29% had early‐onset disease (diagnosis aged <50 years). Median overall survival was 2.5 years (95% confidence interval [CI], 2.2–3.0) for the 159 patients included in survival analysis. Independent factors correlated with poor prognosis included right‐sided primary tumor, neutrophil–lymphocyte ratio >5, increased alkaline phosphatase level (ALP) and an increasing number of sites of metastatic disease. In contrast, metastasectomy was associated with improved overall survival (adjusted HR = 0.29’ 95% CI, 0.16–0.54), with similar survival between patients who had liver and non‐liver metastasectomy sites. Half (10/20) of the BRAF mutant CRC were also microsatellite unstable. The proportion of detected mutations amongst tested samples increased over time for Kirsten Rat Sarcoma (KRAS; OR [per year] = 1.19; 95% CI, 1.01–1.39). Concurrently, the methods of molecular genetics testing employed in routine clinical practice changed towards the adoption of next‐generation sequencing.ConclusionsMetastasectomy in mCRC may be beneficial regardless of the anatomical site of metastasis. The adoption of next‐generation sequencing techniques for molecular genetics testing coincided with a slightly increased rate of detection of KRAS and BRAF mutations, potentially reflecting greater test sensitivity. Further translational research is required in mCRC to define novel targets for treatment.
Earth's Data: Climate Change, Thai Carbon Markets, and the Planetary Atmosphere
Authors: Whitington Jerome 
Published: September 2020

ABSTRACTCarbon markets are the primary regulatory device for confronting climate change. This article analyzes the data practices through which carbon markets connect local reductions in carbon emissions with the planetary atmosphere as such. Carbon markets and related accounting practices are a special form of what Kim Fortun calls “informating environmentalism,” that is, the rendering of environmental issues into problems that can be managed by information systems. I explore the manufacture of carbon offsets (a kind of financial product) through two companies in Thailand who reduce carbon emissions from agricultural processing factories. Criticism of carbon markets may not recognize their importance if it ignores the information practices through which they are made and global problems to which they are addressed. The study of “Earth's data” helps emphasize the anthropological significance of carbon markets. Specifically, carbon regulation seeks to ensure Earth's future habitability by managing the chemical composition of the planetary atmosphere. [climate change, carbon markets, information infrastructure, global assemblage, planetary atmosphere, chemistry, quantification, Thailand]
Peripartum management of a patient with catecholaminergic polymorphic ventricular tachycardia
Authors: Jimenez Erick , Cortez Daniel , McGill Mark , Ambrose Matthew 
Published: September 2020

AbstractCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal cardiac channelopathy characterized by episodes of ventricular tachycardia (VT) during exercise or in stressful situations. As the peripartum period creates a stressful environment, we describe our approach of this rare condition in a very common situation, child birth.
Length of hospital stay after cesarean section in Denmark from 2004 to 2016: A national register‐based study
Authors: Kruse Anne R. , Arendt Linn H. , Jakobsen Dorthe H. , Kehlet Henrik , Lauszus Finn F. , Forman Axel , Uldbjerg Niels , Sundtoft Iben B. , Kesmodel Ulrik S. 
Published: September 2020

AbstractIntroductionLength of hospital stay after birth has decreased during the last decades, but nationwide data on length of hospital stay after cesarean section are lacking. Elements of Enhanced Recovery Programs were reported to reduce the length of hospital stay. The aim of this nationwide study was to describe the length of hospital stay after cesarean section in Denmark from 2004 to 2016 taking into account birth‐ and health‐related factors as well as demographic changes and, further, to assess potential differences between the five Danish regions.Material and methodsLength of hospital stay was assessed in 164 209 deliveries by cesarean section in Denmark from 2004 to 2016. Data were obtained from the Danish National Patient Register. All deliveries by cesarean section at gestational age <22 weeks were excluded. Median length of hospital stay was reported based on crude and adjusted analyses.ResultsThe median length of hospital stay was significantly reduced by 39 hours (95% confidence interval [CI] 37.9‐40.1), from 97 hours (4.0 days) in 2004 to 58 hours (2.4 days) in 2016. Reductions were observed among both planned and emergency cesarean sections. When birth‐ and health‐related factors as well as demographic changes were accounted for, median length of hospital stay was reduced by 30 hours (95% CI 29.3‐30.8) in the period. The decrease in length of hospital stay from 2004 to 2016 varied between the five Danish regions, with adjusted reductions between 19 and 46 hours.ConclusionsA nationwide decrease in length of hospital stay after cesarean section was observed from 2004 to 2016 across all five regions but with significant regional variations. Further studies on the optimal length of hospital stay are needed, especially with regard to implementation of enhanced recovery programs.
Diagnostic accuracy of prenatal ultrasound in identifying the level of the lesion in fetuses with open spina bifida: A systematic review and meta‐analysis
Authors: Di Mascio Daniele , Greco Francesca , Rizzo Giuseppe , Khalil Asma , Buca Danilo , Sorrentino Felice , Vasciaveo Lorenzo , Greco Pantaleo , Nappi Luigi , D’Antonio Francesco 
Published: September 2020

AbstractIntroductionThe role of prenatal ultrasound in correctly identifying the level of the lesion in fetuses with open spina bifida has yet to be determined. The primary aim of this systematic review was to report the diagnostic accuracy of ultrasound in determining the level of the lesion in fetuses with open spina bifida. The secondary aim was to elucidate whether prenatal magnetic resonance imaging (MRI) improves the diagnostic performance of prenatal imaging in correctly identifying the level of the lesion.Material and methodsInclusion criteria were studies reporting the agreement between ultrasound, MRI and postnatal or postmortem assessment of fetuses with spina bifida. Agreement was defined as: complete (when the upper level of the lesion detected prenatally was the same recorded at postnatal or postmortem evaluation), within one (when the upper level of the lesion recorded prenatally was within one vertebral body higher or lower than that reported postnatally) and within two vertebral bodies (when the upper level of the lesion recorded prenatally was within two vertebral bodies higher or lower than that reported postnatally or postmortem evaluation). Meta‐analyses of proportions were used to combine data.ResultsFourteen studies (655 fetuses) were included. Ultrasound was able to identify the correct level of the lesion in 40.9% (95% confidence interval [CI] 26.9‐55.6) of cases. The upper level of the lesion recorded on ultrasound was within one vertebral body in 76.2% (95% CI 65.0‐85.9) of cases and within two segments in 92.4% (95% CI 84.3‐97.7). Fetal MRI detected the exact level of the lesion in 42.5% (95% CI 35.9‐45.2) of cases; the level of the lesion recorded on MRI was higher in 26.4% (95% CI 20.0‐33.3) of cases and lower in 32.4% (95% CI 25.5‐39.7) than that confirmed postnatally. The upper level of the lesion recorded on MRI was within one vertebral body in 76.2% (95% CI 65.9‐85.2) of cases and within two segments in 94.2% (95% CI 90.2‐97.2).ConclusionsBoth ultrasound and MRI have a moderate diagnostic accuracy in identify the upper level of the lesion in fetuses with open spina bifida.