bluuebunny/crossref_metadata_2025_split huggingface dataset:
МАТЕМАТИЧНЕ МОДЕЛЮВАННЯ ПОПИТУ
Authors: Циганчук Роман , Мельник Надія 
Published: November 2019

Розроблено математичну модель споживчого попиту з пом’якшеними вимогами щодо диференційованості функції корисності. Для знаходження необхідної аналізові кількості частинних похідних використано співвідношення між середніми і граничними її величинами. При моделюванні попиту використовується два основні підходи: за першого підходу використовується побудова функції корисності і карт байдужості; за другого — встановлюється статистичний зв’язок між попитом, доходом і цінами. Функція корисності повинна відповідати вимогам про неперервну зміну її аргументів, неперервність самої функції та існування необхідного числа її похідних. При розв’язуванні практичних задач, пов’язаних із моделюванням попиту, виконання таких вимог не завжди можливе. У роботі функція корисності представлена як добутки її відношень до аргументів на самі аргументи. Такий підхід усуває проблему знаходження похідних функції корисності і суттєво розширює коло задач, які розв’язуються за допомогою економіко-математичної моделі споживчого попиту.
Attitudes Towards Functional Foods Scale: Psychometric Proprieties and Adaptation for Use Among Adolescents
Authors: Oliveira Leandro , Poínhos Rui , Sousa Francisco 
Published: November 2019

Introduction: Functional foods are those that promote health and well-being and/or decrease the risk of certain chronic diseases. It is known that young people’ knowledge about functional foods is low. The aim of this study is to assess the psychometric proprieties of the “Attitudes towards Functional Foods Scale” in a sample of adolescents and, based on that analysis, adapting the scale for its use among this population group.Material and Methods: After a pre-test, the scale was applied to 340 students attending the 3rd cycle of basic education in Terceira island (Azores, Portugal), whose ages ranged between 11 and 19 years (mean = 14.0, standard deviation = 1.2). We analyzed the scale’s internal consistency and construct validity.Results: The study of the psychometric proprieties led to the exclusion of one item. Cronbach’s alpha (α = 0.876) showed a good internal consistency of the scale, and factor analysis revealed that, as the original (adults) version, it presents an unifactorial structure.Discussion: The scale showed to be an instrument easy and quick to apply among adolescents. We emphasize that its application should be preceded by the clarification on the concept of functional foods in order to ensure the adequacy of the answers.Conclusion: This study has demonstrated the adequacy of the Attitudes Towards Functional Foods Scale to assess Portuguese adolescents’ perception regarding functional foods, highlighting the need of using its adapted version.
EXPERIMENTAL STUDY THE EFFECT ANGLE OF BLADE ON THE ELECTRICAL POWER OUTPUT OF PROPELLER PICOHYDRO TURBINE
Authors: Shalih Abdullah , Widodo Purwadi Joko , Himawanto Dwi Aries 
Published: November 2019

<p><em>This study aimed to analyze the effect of angle of blade on the horizontal flow to the performance of the propeller water turbine. The experiments were performed using several test parameters including the angle of blade on the variation mass flow rate of water. With potential head 2 meters and variated turbine blade angle to achieved optimal power generated. The result showed that the variation of angle of blade with 30<sup>0</sup> angles and 11.6 l/s mass flow rate of water was the best variation to improve the performance of the propeller water turbine. The best variation can generated 32 Watt of electric power.</em></p>
Transient Wellbore-Pressure-Buildup Correlation Helps Engineers To Ensure HIPPS Safe Operation
Authors: Homoud Ahmed , Gajbhiye Rahul , Al-Shehri Dhafer 
Published: November 2019

Summary
The objective of this study is to develop a correlation for transient wellbore-pressure buildup and relate it to the high-integrity pressure-protection system (HIPPS) response time in multiphase flow. The developed correlation gives an accurate estimate of the pressure buildup with time under shut-in conditions. It provides guidelines to set the HIPPS activation pressure considering different reservoir and wellbore parameters to ensure the safety and timely response of HIPPS.
The correlation was developed by performing transient simulations to calculate the wellbore-pressure-buildup time under shut-in conditions accounting for different reservoir and wellbore parameters. The input data were gathered from three oil fields with various fluid properties, reservoir pressures, productivity indices (PIs), depths, and shut-in wellhead pressures (SIWHPs). Before feeding the data to the dynamic flow simulator, the reservoir data were tuned to match the well-flow conditions. After completing the transient simulation for every well, the pressure-buildup data as a function of time were collected and used as input to develop a correlation using the nonlinear-regression method.
The results of this study show that the most influential parameters on the pressure-buildup behaviors are fluid compressibility, PI, flowing wellhead pressure (FWHP), and well measured depth (MD). In addition, we observed that there is a strong relationship between the fluid compressibility at FWHP condition and the time it takes to pressurize the wellbore to maximum pressure. The higher the fluid compressibility, the longer it takes the system to pressurize. The newly developed correlation provides a guideline for setting the HIPPS activation pressure and ensuring the wells’ safe operation.
Evaluation of venous pathology of the lower extremities with triggered angiography non-contrast-enhanced magnetic resonance imaging (TRANCE-MRI)
Authors: Huang Yao-Kuang , Tseng Yuan-Hsi , Lin Chih-Hung , Tsai Yuan-Hsiung , Hsu Yin-Chen , Wang Shih-Chung , Chen Chien-Wei 
Published: November 2019

Abstract
Background: To explore the diagnostic performance of triggered angiography non-contrast-enhanced magnetic resonance imaging (TRANCE-MRI) for the evaluation of venous pathology of the lower extremity.
Methods: This was a single-centre prospective cohort study of 25 patients with suspected venous disease in the lower extremities. Each patient received Doppler ultrasonography (for venous evaluation) before the scheduled TRANCE-MRI (for venous and arterial evaluations) on a 1.5T MR scanner (Philips Ingenia, Philips Healthcare, Best, the Netherlands), followed by lymphography and computed tomography angiography that were arranged according to the diagnostic indications.
Results: The sensitivity, specificity and accuracy of TRANCE-MRI were 85.7%, 88/9% and 88%, respectively. The inter-rater agreement for deep vein thrombosis (DVT) of the thigh between the ultrasonography and TRANCE-MRI results was substantial agreement (Cohen's kappa κ, 0.72). In ultrasonography-negative cases, TRANCE-MRI detected four additional cases (16%, 4/25) of DVT; three cases (12%, 3/25) of venous compression caused by pelvic lymphadenopathy, hip prosthesis or knee joint effusion; one case (4%, 1/25) of vena cava anomaly; two cases (8%, 2/25) of occult peripheral artery disease (PAD); and one case (4%, 1/25) of an occluded bypass graft.
Conclusion : TRANCE-MRI can be used as an alternative and objective tool for assessing lower extremity diseases, especially suspected venous pathology. Compared with ultrasonography, TRANCE-MRI plays a better role in assessing varicose veins of the lower extremities and deep veins of the pelvis and abdomen. However, false-positive results may occur in the left common iliac vein of elderly patients. Finally, occult PAD rarely occurs in patients with suspected lower extremity venous disease. Therefore, we recommend performing the TRANCE-MRV protocol instead of the full protocol (MRV+MRA) in the clinical setting in patients with venous scenarios.
The effect of intraoperative lidocaine versus esmolol infusion on postoperative analgesia in laparoscopic cholecystectomy: A randomized clinical trial
Authors: Bajracharya Joshan Lal , Subedi Asish , Pokharel Krishna , Bhattarai Balkrishna 
Published: November 2019

Abstract
Background: As a part of multimodal analgesia for laparoscopic cholecystectomy, both intraoperative lidocaine and esmolol facilitate postoperative analgesia. Our objective was to compare these two emerging strategies that challenge the use of intraoperative opioids. We aimed to assess if intraoperative esmolol infusion is not inferior to lidocaine infusion for opioid consumption after laparoscopic cholecystectomy.
Methods: In this prospective, randomized, double-blind, non-inferiority clinical trial, 90 female patients scheduled for elective laparoscopic cholecystectomy received either intravenous (IV) lidocaine bolus 1.5 mg/kg at induction followed by an infusion (1.5 mg/ kg/hour) or IV bolus of esmolol 0.5 mg/kg at induction followed by an infusion (5-15 µg/kg/min) till the end of surgery. Remaining aspect of anesthesia followed a standard protocol apart from no intraoperative opioid supplementation. Postoperatively, patients received either morphine or tramadol IV to maintain visual analogue scale (VAS) scores ≤ 3. The primary outcome was opioid consumption (in morphine equivalents) during the first 24 postoperative hours. Pain and sedation scores, time to first perception of pain and void, and occurrence of nausea/vomiting were secondary outcomes measured up to 24 hours postoperatively.
Results: Two patients in each group were excluded from the analysis. The postoperative median (IQR) morphine equivalent consumption in patients receiving esmolol was 1 (0-1.5) mg compared to 1.5 (1-2) mg in lidocaine group ( p =0.27). The median pain scores at various time points were similar between the two groups ( p >0.05). More patients receiving lidocaine were sedated in the post-anesthesia care unit (PACU) than those receiving esmolol (p<0.05); however, no difference was detected later.
Conclusion: Infusion of esmolol is not inferior to lidocaine in terms of opioid requirement and pain severity in the first 24 hours after surgery. Patients receiving lidocaine were more sedated during their stay in PACU than those receiving esmolol.
Transcriptomic and proteomic analysis reveals mechanisms of low pollen-pistil compatibility during water lily cross breeding
Authors: Sun Chun-Qing , Chen Fa-Di , Teng Nian-Jun , Yao Yue-Mei , Shan Xi , Dai Zhong-liang 
Published: November 2019

Abstract
Background: In water lily (Nymphaea) hybrid breeding, breeders often encounter non-viable seeds, which make it difficult to transfer desired or targeted genes of different Nymphaea germplasm. We found that pre-fertilization barriers were the main factor in the failure of the hybridization of Nymphaea. The mechanism of low compatibility between the pollen and stigma remains unclear; therefore, we studied the differences of stigma transcripts and proteomes at 0, 2, and 6 hours after pollination (HAP). Moreover, some regulatory genes and functional proteins that may cause low pollen-pistil compatibility in Nymphaea were identified. Results: RNA-seq was performed for three comparisons (2 vs 0 HAP, 6 vs 2 HAP, 6 vs 0 HAP), and the number of differentially expressed genes (DEGs) was 8,789 (4,680 were up-regulated), 6,401 (3,020 were up-regulated), and 11,284 (6,148 were up-regulated), respectively. Using label-free analysis, 75 (2 vs 0 HAP) proteins (43 increased and 32 decreased), nine (6 vs 2 HAP) proteins (three increased and six decreased), and 90 (6 vs 0 HAP) proteins (52 increased and 38 decreased) were defined as differentially expressed proteins (DEPs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that the DEGs and DEPs were mainly involved in cell wall organization or biogenesis, S-adenosylmethionine (SAM) metabolism , hydrogen peroxide decomposition and metabolism, reactive oxygen species (ROS) metabolism, secondary metabolism, secondary metabolite biosynthesis, and phenylpropanoid biosynthesis. Conclusions: Our transcriptomic and proteomic analysis highlighted specific genes, incuding those in ROS metabolism, biosynthesis of flavonoids, SAM metabolism, cell wall organization or biogenesis and phenylpropanoid biosynthesis that warrant further study in investigations of the pollen-stigma interaction of water lily. This study strengthens our understanding of the mechanism of low pollen-pistil compatibility in Nymphaea at the molecular level, and provides a theoretical basis for overcoming the pre-fertilization barriers in Nymphaea in the future.
Simulation and minimization: Technical advances for factorial experiments designed to optimize clinical interventions
Authors: Kuhn Jocelyn Lara , Sheldrick Radley Christopher , Broder-Fingert Sarabeth , Chu Andrea , Fortuna Lisa , Jordan Megan , Rubin Dana , Feinberg Emily 
Published: November 2019

Abstract
Background: The Multiphase Optimization Strategy (MOST) is designed to maximize the impact of clinical healthcare interventions, which are typically multicomponent and increasingly complex. MOST often relies on factorial experiments to identify which components of an intervention are most effective, efficient, and scalable. When assigning participants to conditions in factorial experiments, researchers must be careful to select the assignment procedure that will result in balanced sample sizes and equivalence of covariates across conditions while maintaining unpredictability.
Methods: In the context of a MOST optimization trial with a 2x2x2x2 factorial design, we used computer simulation to empirically test five subject allocation procedures: simple randomization, stratified randomization with permuted blocks, maximum tolerated imbalance (MTI), minimal sufficient balance (MSB), and minimization. We compared these methods across the 16 study cells with respect to sample size balance, equivalence on key covariates, and unpredictability. Leveraging an existing dataset to compare these procedures, we conducted 250 computerized simulations using bootstrap samples of 304 participants.
Results: Simple randomization, the most unpredictable procedure, generated poor sample balance and equivalence of covariates across the 16 study cells. Stratified randomization with permuted blocks performed well on stratified variables but resulted in poor equivalence on other covariates and poor balance. MTI, MSB, and minimization had higher complexity and cost. MTI resulted in balance close to pre-specified thresholds and a higher degree of unpredictability, but poor equivalence of covariates. MSB had 19.7% deterministic allocations, poor sample balance and improved equivalence on only a few covariates. Minimization was most successful in achieving balanced sample sizes and equivalence across a large number of covariates, but resulted in 34% deterministic allocations. Small differences in proportion of correct guesses were found across the procedures.
Conclusions: Computer simulation was highly useful for evaluating tradeoffs among randomization procedures. Based on the computer simulation results and priorities within the study context, minimization with a random element was selected for the planned research study. Minimization with a random element, as well as computer simulation to make an informed randomization procedure choice, are utilized infrequently in randomized experiments but represent important technical advances that researchers implementing multi-arm and factorial studies should consider.
Measles Outbreak Investigation in Artuma Fursi Woreda, Oromia Zone, Amhara Region, Ethiopia, 2018: A case control study
Authors: Tariku Mengistie Kassahun , Misikir Sewnet Wongiel 
Published: November 2019

Abstract
Objective: To confirm the existence of Outbreak, describe cases in person, place and time, and identify determinants of the outbreak. Unmatched case control study in the ratio of 1:4 (38 cases and 152 controls) was conducted in Artuma fursi woreda from July 13- August 1 /2018. Data were collected with standard questionnaires. Collected data were entered into Epi Info version 7 and exported to Statistical package for social science (SPSS) version 23 for analysis. Results: A total of 38 cases and 1 death with attack rate and case fatality rate 11.8/100,000 and 2.6% respectively. All study participants had not vaccination history. Females and age group 5-14 were more affected. Being 5-14 years old versus (vs) 15 years [adjusted odd ratio (AOR) =3.53; 95% CI; 1.52-8.45)], contact with cases vs no contact with cases [AOR=2.78; 95% CI; 1.23-8.67] and travel history 7-18 days prior onset of illness vs no travel history [AOR= 2.53; 95% CI; 1.31-7.24] were significantly associated with contracting measles. Routine and supplement immunization should be strengthened to reduce future occurrence of outbreak. Keywords: Measles, outbreak, Artuma fursi woreda
Tobacco Use and Associated Risk Factors in Burkina Faso: Results from a Population-Based Cross-Sectional Survey.
Authors: Bonnechère Bruno , Kadari Cissé , Tiéba Millogo , Gautier Ouédraogo H. , Franck Garanet , Mariam Ouedraogo A. , Gabriela Boyle , Sékou Samadoulougou , Seni Kouanda , Fati Kirakoya-Samadoulougou 
Published: November 2019

Abstract
Background: Tobacco is a leading preventable cause of non-communicable diseases (NCDs). Studies characterizing the prevalence of tobacco use in low-income countries are lacking. This study describes the prevalence of tobacco use in Burkina Faso and its associated factors.
Methods : Data from the 2013 Burkina Faso World Health Organization (WHO) Stepwise approach to Surveillance (STEPS) were analyzed. The prevalence of any tobacco product use, cigarette smoking, and other tobacco use was calculated. Logistic regression analyses identified factors associated with tobacco use. Overall, 4,691 people were included in this analysis.
Results: The prevalence of any tobacco use was 19.8% (95% CI: 18.4–21.2). Tobacco use was higher for men (29.2% [27.0–31.5]) than women (11.8% [10.3–13.4]). The prevalence of smoked tobacco was 11.3% (10.3–12.4), with a significantly higher prevalence among men (24.5% [22.1–27.0]) than women (0.1% [0.01–0.3]). The overall prevalence of other tobacco use was 8.9% (7.4–10.7), with lower values for men (5.6% [4.1–7.2]) compared to women (11.7% [9.4–14.1]). Tobacco smoking among men was significantly associated with an increased age and alcohol consumption. The analysis of risk factors for other tobacco use stratified by gender showed that age, education, residence, and alcohol consumption were significantly associated with consumption for women, and age and alcohol consumption for men.
Conclusion: Tobacco use is common in Burkina Faso. To effectively reduce tobacco use in Burkina Faso, a comprehensive tobacco control program should consider associated factors, such as gender, age, and alcohol consumption.
Treating periodontitis-A systematic review and meta-analysis comparing ultrasonic and manual subgingival scaling at different probing pocket depths.
Authors: Zhang Xin , Hu Zixuan , Zhu Xuesong , Li Wenjie , Chen Jun 
Published: November 2019

Abstract
Background: Mechanical plaque removal has been commonly accepted to be the basis for periodontal treatment. This study aims to compare the effectiveness of ultrasonic and manual subgingival scaling at different initial probing pocket depths (PPD) in periodontal treatment. Methods: Public databases were searched. Weighted mean differences in PPD and clinical attachment loss (CAL) reduction were estimated by random effects model. Bleeding on probing (BOP), gingival recession (GR), and post-scaling residual dental calculus were analyzed by comparing the results of each study. Results: Ten randomized controlled trials were included out of 1,434 identified. Selected outcomes were PPD and CAL. Initial PPD and follow-up periods formed subgroups. For 3-month follow-up: (1) too few shallow initial pocket studies available to draw a conclusion; (2) the heterogeneity of medium depth studies was so high that could not be merged to draw a conclusion; (3) deep pocket studies showed no statistical differences in PPD and CAL reduction between ultrasonic and manual groups. For 6-month follow-up: (1) too few shallow initial PPD studies to draw a conclusion; (2) at medium pocket depth, PPD reduction showed manual subgingival scaling better than ultrasound. No statistical differences were observed in CAL reduction between the two approaches; (3) for deep initial PPD studies, both PPD and CAL reduction showed manual subgingival scaling better. GR results indicated no statistical differences at medium and deep initial pocket studies between the two methods. BOP results showed more reduction at deep pocket depths with manual subgingival scaling. No conclusion could be drawn about residual dental calculus. Conclusion: When initial probing pocket depth was 4-6mm, PPD reduction proved manual scaling superior to ultrasonic subgingival scaling, but CAL and GR results showed no statistical differences between the two means. When initial probing pocket depth was ≥6mm, PPD, CAL and BOP reductions suggested that manual subgingival scaling was superior to ultrasonic subgingival scaling, but GR results showed no statistical differences. No conclusion could be drawn about residual dental calculus.
Surgical treatment to multiple primary lung cancer patients: A systematic review and meta-analysis
Authors: Author) Ting-Fei Chen(Former Corresponding , Xie Chun-Ying , Rao Bing-Yu , Shan Shi-Chao , Zhang Xin , Zeng Bo , Lei Yi-Yan , Author) Hong-He Luo(New Corresponding 
Published: November 2019

Abstract
Background As there is no consensus on the optimal surgery strategy for multiple primary lung cancer (MPLC), we conducted this study to address this issue by comparing the prognosis of MPLC patients underwent different surgical strategies including sublobar resection and the standard resection through a systemic review and meta-analysis. Methods Relevant literature was obtained from three databases including PubMed, Embase and Web of Science. Inclusion and exclusion criteria were set for the screening of articles to be selected for further conduction of systemic review and meta-analysis. The HRs of OS of the sublobar group compared with standard resection group were extracted directly or calculated indirectly from included researches. ResultsTen researches published from 2000 to 2017 were included in this study, with 468 and 445 MPLC cases for the standard resection group and sublobar resection group respectively. The result suggested that OS of MPLC patients underwent sublobar resection (segmentectomy or wedge resection for at least one lesion) was comparable with those underwent standard resection approach (lobectomy or pneumonectomy for all lesions), with HR 1.07, 95% CI 0.67 - 1.71, p = 0.784. Further analysis found no difference in subgroups of synchronous and metachronous (from second metachronous lesion), different population region and dominant sex type. Conclusions This study may reveal that sublobar resection is acceptable for patients with MPLC at an early stage, because of the equivalent prognosis to the standard resection and better pulmonary function preservation. Further research is needed to validate these findings.