bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase I trial to assess the biologic effect of CBM588 (Clostridium butyricum) in combination with nivolumab plus ipilimumab (nivo/ipi) in patients with metastatic renal cell carcinoma (mRCC).
Authors: Bergerot Paulo Gustavo , Dizman Nazli , Ruel Nora , Frankel Paul Henry , Hsu Joann , Pal Sumanta K. 
Published: February 2020

TPS764 Background: The combination of the immune checkpoint inhibitors (ICIs) nivo/ipi is standard of care for pts with intermediate/poor-risk clear cell RCC. Although data are encouraging, less than 50% of pts will exhibit partial or complete response with nivo/ipi, and approximately 20% of pts will progress through this regimen. Studies have shown that response to ICIs may be modulated by the gut microbiome (Routy et al Science 2018), and that certain gut bacteria (e.g., Bifidobacterium spp) may predispose pts to response (Caitano et al ASCO GU 2017). CBM588 is a strain of Clostridium butyricum, a Gram-positive bacillus which produces short-chain fatty acids. It promotes the growth of commensal gut bacteria like Bifidobacterium, Lactobacillus and Bacteroides spp, and has been shown to enhance Th1 cells and IL-10 production with immunomodulatory effects. Here, we present the study design of an ongoing phase I trial to assess the biologic effect of CBM588 in combination with nivo/ipi in pts with mRCC. Methods: This is a single institution phase I trial. Pts will be randomized to one of two treatment arms. The experimental arm will receive the standard dose/schedule for nivo/ipi (3 mg/kg / 1 mg/kg Q3w for 12w, followed by nivo alone Q4w) plus CBM588 (60 mg PO 3x/d). The control arm will receive nivo/ipi at standard dose/schedule. Key eligibility criteria include intermediate/poor-risk mRCC, no concurrent antibiotic therapy and no prior systemic treatment. The primary objective is to determine the biologic effect of CBM588 + nivo/ipi in the modulation of the gut microbiome, measured by the change in Bifidobacterium spp and Shannon index (a measure of microbiome diversity). Secondary objectives include clinical efficacy (progression free survival by RECIST 1.1) and assessment of systemic immune-modulation effects through the analysis of circulating Tregs, MDSCs, and circulating cytokines/chemokines. Stool samples and serum correlatives will be collected on weeks 1 and 13 of treatment. A two-group t-test with a one-sided type I error of 0.05 will be used to assess the study primary endpoints. Clinical trial information: NCT03829111.
To Address Burnout in Oncology, We Must Look to Teams: Reflections on an Organizational Science Approach
Authors: LeNoble Chelsea A. , Pegram Riley , Shuffler Marissa L. , Fuqua Tranaka , Wiper Donald W. 
Published: February 2020

PURPOSE: Despite decades of effort, burnout among physicians remains elevated compared with that of other working populations, and it yields catastrophic consequences, including medical errors and physician suicide. Burnout leaves oncologists feeling like they are alone, but this is not the case—it affects everyone. To effectively address burnout, it is not enough to look only at oncologists; instead, we must include all those involved in the delivery of cancer care. With this aim, we present an overview of the organizational science strategies and initial evidence for the value of a comprehensive, team-focused approach to addressing oncology provider burnout. METHODS: We describe the development of a team-focused burnout intervention approach, implemented for oncology providers, which focuses on the importance of encouraging communication and psychological safety to reduce feelings of isolation and fragmentation. We discuss the initial findings from 1 such team-based initiative currently underway within an academic medical center, presenting data from 409 cancer care providers embedded in 30 oncology units participating in this intervention approach. RESULTS: Preliminary results demonstrate that units that integrated a team-focused intervention for burnout reported significantly higher levels of teamwork and lower levels of burnout. We also describe lessons learned and recommendations for implementing this type of intervention on the basis of best practices from organizational science. CONCLUSION: This approach can positively affect the delivery of cancer care, interprofessional relationships among oncology staff, and the well-being of both patients and providers. Treating physician burnout alone will treat 1 symptom of the overall issue of burnout in oncology. As burnout pulls oncology clinicians apart, our solution must be to bring them together.
Rectal gonorrhoea and chlamydia among men who have sex with men in coastal Kenya
Authors: Ngetsa Caroline J. , Heymann Marc W. , Thiong'o Alex , Wahome Elizabeth , Mwambi John , Karani Clara , Menza Nelson C. , Mwashigadi Grace , Muturi Margaret W. , Graham Susan M. , Mugo Peter M. , Sanders Eduard J. 
Published: February 2020

Background: Men who have sex with men (MSM) have a higher prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections compared to the rest of the population, often remaining undiagnosed. In Kenya, prevalence of rectal CT and NG infection and NG antimicrobial sensitivity are poorly described. Methods: MSM who reported receptive anal intercourse (RAI) were recruited from an ongoing human immunodeficiency virus acquisition and treatment study in coastal Kenya in 2016-2017. Rectal swabs were collected at two time points 6 months apart to estimate prevalence and incidence of CT/NG infection using a molecular point-of-care assay. Participants positive for CT or NG were treated according to national guidelines. NG culture and antimicrobial susceptibility testing was performed. Participant and risk behaviour characteristics were collected and association with baseline CT/NG prevalence assessed by multivariable regression analysis. Results: Prevalence of CT/NG in 104 MSM was 21.2% (CT 13.5%, NG 9.6%, dual infection 1.9%) at baseline and 25.9% in 81 MSM at follow-up (CT 14.8%, NG 14.8%, dual infection 3.7%). CT/NG incidence was estimated at 53.0 (95% CI, 34.5-81.3) per 100 person-years. Most CT/NG positive participants were asymptomatic: 95.5% at baseline and 100% at follow-up. CT/NG infection was associated with being paid for sex [adjusted odds ratio (aOR)=6.2, 95% CI (1.7-22.9)] and being in formal employment [aOR=7.5, 95% CI (1.1-49.2)]. Six NG isolates were obtained at follow-up; all were susceptible to ceftriaxone and cefixime and all were resistant to penicillin, tetracycline and ciprofloxacin. Conclusions: There is a high prevalence and incidence of asymptomatic rectal CT and NG in MSM reporting RAI in coastal Kenya. MSM who were paid for sex or had formal employment were more likely to be infected with CT/NG suggesting increased risk behaviour during transactional sex. Antimicrobial susceptibility results suggest that current antibiotic choices in Kenya are appropriate for NG treatment.
Calculative Trust and Interfirm Contracts
Authors: Susarla Anjana , Holzhacker Martin , Krishnan Ranjani 
Published: February 2020

Interfirm contracts are plagued by opportunism arising from exchange hazards that increase the seller’s gains from holdup in fixed price contracts. These exchange hazards are higher when the seller can engage in unverifiable deliberate obfuscation. Although cost-plus contracts reduce holdup losses, they suffer from cost inefficiency. Past research has underscored the importance of trust as a control instrument to mitigate losses from exchange hazards, especially social relational trust that develops from past experiences. However, trust can also be calculative when it develops from the expectation of future economic gains to the buyer-seller dyad. We identify two dyadic mechanisms that generate calculative trust and curtail the likelihood of cost-inefficient behavior in cost-plus contracts. These mechanisms include future potential and bilateral reputation capital for cost containment. Analysis using probit estimations on 149 information technology outsourcing contracts for the period 1998 to 2005 suggests that calculative trust increases the likelihood of cost-plus contracts. Thus, calculative trust can mitigate inefficiencies in interfirm contracts.This paper was accepted by Shiva Rajgopal, accounting.
Profil Vertikal Logam Berat Tembaga (Cu), Nikel (Ni), dan Mangan (Mn) di Core Sedimen Perairan Pantai Marunda, Teluk Jakarta
Authors: Darmansyah Kresna Rangga , Wulandari Sri Yulina , Marwoto Jarot , Supriyantini Endang 
Published: February 2020

Heavy metals contained in the waste enter to the Marunda coastal waters in Jakarta Bay through the Tiram river, come from the Jabodetabek region which is an industrial and residential area. They will be deposited and accumulated in the bed sediments and potentially to cause contamination in the waters as well. The study was conducted to investigate vertical profiles of heavy metals Cu, Ni, and Mn based on sediment depth and the correlation between the concentration of heavy metals and the grain size of sediments. Coring method was used for sampling the sediments at 1-3 cm, 4-6 cm and 7-9 cm of depths. Samples were analyzed using AAS method to determine Cu, Ni, and Mn concentrations. Sieving and pipetting methods were used to determine the grain size of the sediments. The results showed that the average concentration of heavy metals Cu, Ni, and Mn in the top layer was 7.74 ppm; 8.17 ppm; 1345.03 ppm. The middle layer was 6.91 ppm; 7.48 ppm; 1279.35 ppm. The bottom layer was 7.36 ppm; 7.79 ppm; 1413.66 ppm. The concentration of Cu heavy metal had a positive correlation with the sand fraction, while the heavy metals Ni and Mn had a positive correlation with the mud fraction. Logam berat yang terkandung dalam limbah masuk ke perairan pantai Marunda di Teluk Jakarta melalui sungai Tiram, berasal dari daerah Jabodetabek yang merupakan kawasan industri dan pemukiman. Logam berat tersebut akan mengendap dan terakumulasi di sedimen dasar perairan dan berpotensi menimbulkan pencemaran perairan. Penelitian ini bertujuan untuk mengetahui profil logam berat Tembaga, Nikel, dan Mangan secara vertikal berdasarkan kedalaman sedimen dan korelasi antara konsentrasi logam berat dengan ukuran butir sedimen. Pengambilan sampel sedimen dilakukan menggunakan metode coring untuk kedalaman 1-3 cm, 4-6 cm, dan 7-9 cm. Selanjutnya sampel sedimen dianalisis menggunakan metode AAS untuk mengetahui konsentrasi logam berat Cu, Ni, dan Mn. Metode sieving dan pipetting digunakan untuk mengetahui ukuran butir sedimen. Nilai konsentrasi rata-rata logam berat Cu, Ni, dan Mn pada lapisan atas untuk setiap stasiun berurutan sebesar 7,74 ppm; 8,17 ppm; 1345,03 ppm. Lapisan tengah sebesar 6,91 ppm; 7,48 ppm; 1279,35 ppm. Lapisan bawah sebesar 7,36 ppm; 7,79 ppm; 1413,66 ppm. Konsentrasi logam berat Cu mempunyai korelasi positif terhadap fraksi pasir, sedangkan logam berat Ni dan Mn mempunyai korelasi positif terhadap fraksi lumpur.
Mind the gap
Authors: Khayati Mourad , Lerner Alberto , Tymchenko Zakhar , Cudré-Mauroux Philippe 
Published: February 2020

Recording sensor data is seldom a perfect process. Failures in power, communication or storage can leave occasional blocks of data missing, affecting not only real-time monitoring but also compromising the quality of near- and off-line data analysis. Several recovery (imputation) algorithms have been proposed to replace missing blocks. Unfortunately, little is known about their relative performance, as existing comparisons are limited to either a small subset of relevant algorithms or to very few datasets or often both. Drawing general conclusions in this case remains a challenge.
In this paper, we empirically compare twelve recovery algorithms using a novel benchmark. All but two of the algorithms were re-implemented in a uniform test environment. The benchmark gathers ten different datasets, which collectively represent a broad range of applications. Our benchmark allows us to fairly evaluate the strengths and weaknesses of each approach, and to recommend the best technique on a use-case basis. It also allows us to identify the limitations of the current body of algorithms and suggest future research directions.
Thiophene-based Schiff base ligand as ionophore for Ni(II)-selective polyvinyl chloride membrane electrode
Authors: Suman Shankar , Singh Ram 
Published: February 2020

Abstract
A synthesized Schiff base 2-acetylthiophene semicarbazone (3) was used for the preparation of Ni2+ selective polyvinyl chloride (PVC) membrane electrode. The prepared electrode with the optimized composition, PVC:3:sodium tetraphenylborate:di-n-butylphthalate as 33:6:3:58 exhibited a Nernstian response over the working range of 5.0 × 10−6–5.0 × 10−2 mol l−1 with a slope of 29.0 ± 0.3 mV/concentration. The electrode showed good selectivity towards Ni2+ with respect to several metal ions in the pH range of 2.5–10.0 in <15 s with a detection limit of 4.7 × 10−6 mol l−1. The electrode showed the additional benefit of working in partially nonaqueous media having up to 15% (v/v) methanol or ethanol. This electrode was also successfully applied in Ni2+ ion potentiometric titration with ethylenediaminetetraacetic acid as an indicator electrode.
Visual rhetoric based on triadic approach: Intellectual knowledge, visual representation and aesthetics as modality
Authors: Köksal Fatma Nazlı , İnatçı Ümit 
Published: February 2020

Abstract
The aim of the present study is to evaluate Sonja Foss’s Rhetorical Schema for the Evaluation of Visual Imagery (1994) as well as reflect upon several points for further consideration; and finally suggest a renewed triadic approach as a method for analyzing art-relevant visual imagery. The triadic approach to be discussed assumes three correlative layers: the intellectual knowledge, function of the artistic content as the visual representational component, and aesthetics as modality. This study will include the analysis of a print advertisement that used an artwork as its content of visual rhetoric, and this will inform further discussions on the proposed approach. The contribution of this renewed triadic approached to the field of visual rhetoric has the advantage of expanding and possibly improving rhetorical analysis methods of visual imagery.
Defining Near-Term to Long-Term Research Opportunities to Advance Metrics, Models, and Methods for Smart and Sustainable Manufacturing
Authors: Shankar Raman Arvind , Haapala Karl R. , Raoufi Kamyar , Linke Barbara S. , Bernstein William Z. , Morris K. C. 
Published: February 2020

Abstract
Over the past century, research has focused on continuously improving the performance of manufacturing processes and systems—often measured in terms of cost, quality, productivity, and material and energy efficiency. With the advent of smart manufacturing technologies—better production equipment, sensing technologies, computational methods, and data analytics applied from the process to enterprise levels—the potential for sustainability performance improvement is tremendous. Sustainable manufacturing seeks the best balance of a variety of performance measures to satisfy and optimize the goals of all stakeholders. Accurate measures of performance are the foundation on which sustainability objectives can be pursued. Historically, operational and information technologies have undergone disparate development, with little convergence across the domains. To focus future research efforts in advanced manufacturing, the authors organized a one-day workshop, sponsored by the U.S. National Science Foundation, at the joint manufacturing research conferences of the American Society of Mechanical Engineers and Society of Manufacturing Engineers. Research needs were identified to help harmonize disparate manufacturing metrics, models, and methods from across conventional manufacturing, nanomanufacturing, and additive/hybrid manufacturing processes and systems. Experts from academia and government labs presented invited lightning talks to discuss their perspectives on current advanced manufacturing research challenges. Workshop participants also provided their perspectives in facilitated brainstorming breakouts and a reflection activity. The aim was to define advanced manufacturing research and educational needs for improving manufacturing process performance through improved sustainability metrics, modeling approaches, and decision support methods. In addition to these workshop outcomes, a review of the recent literature is presented, which identifies research opportunities across several advanced manufacturing domains. Recommendations for future research describe the short-, mid-, and long-term needs of the advanced manufacturing community for enabling smart and sustainable manufacturing.
More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment
Authors: Maksour Simon , Ooi Lezanne , Dottori Mirella 
Published: February 2020

AbstractThe molecular mechanisms governing normal neurodevelopment are tightly regulated by the action of transcription factors. Repressor element 1 (RE1) silencing transcription factor (REST) is widely documented as a regulator of neurogenesis that acts by recruiting corepressor proteins and repressing neuronal gene expression in non-neuronal cells. The REST corepressor 1 (CoREST1), CoREST2, and CoREST3 are best described for their role as part of the REST complex. However, recent evidence has shown the proteins have the ability to repress expression of distinct target genes in a REST-independent manner. These findings indicate that each CoREST paralogue may have distinct and critical roles in regulating neurodevelopment and are more than simply “REST corepressors,” whereby they act as independent repressors orchestrating biological processes during neurodevelopment.
Cortico-Thalamo-Cortical Circuits of Mouse Forelimb S1 Are Organized Primarily as Recurrent Loops
Authors: Guo KuangHua , Yamawaki Naoki , Barrett John M. , Tapies Martinna , Shepherd Gordon M. G. 
Published: February 2020

Cortical projections to the thalamus arise from corticothalamic (CT) neurons in layer 6 and pyramidal tract-type (PT) neurons in layer 5B. We dissected the excitatory synaptic connections in the somatosensory thalamus formed by CT and PT neurons of the primary somatosensory (S1) cortex, focusing on mouse forelimb S1. Mice of both sexes were studied. The CT neurons in S1 synaptically excited S1-projecting thalamocortical (TC) neurons in subregions of both the ventral posterior lateral and posterior (PO) nuclei, forming a pair of recurrent cortico-thalamo-cortical (C-T-C) loops. The PT neurons in S1 also formed a recurrent loop with S1-projecting TC neurons in the same subregion of the PO. The PT neurons in the adjacent primary motor (M1) cortex formed a separate recurrent loop with M1-projecting TC neurons in a nearby subregion of the PO. Collectively, our results reveal that C-T-C circuits of mouse forelimb S1 are primarily organized as multiple cortical cell-type-specific and thalamic subnucleus-specific recurrent loops, with both CT and PT neurons providing the strongest excitatory input to TC neurons that project back to S1. The findings, together with those of related studies of C-T-C circuits, thus suggest that recurrently projecting thalamocortical neurons are the principal targets of cortical excitatory input to the mouse somatosensory and motor thalamus.SIGNIFICANCE STATEMENTBidirectional cortical communication with the thalamus is considered an important aspect of sensorimotor integration for active touch in the somatosensory system, but the cellular organization of the circuits mediating this process is not well understood. We used an approach combining cell-type-specific anterograde optogenetic excitation with single-cell recordings targeted to retrogradely labeled thalamocortical neurons to dissect these circuits. The findings reveal a consistent pattern: cortical projections to the somatosensory thalamus target thalamocortical neurons that project back to the same cortical area. Commonalities of these findings to previous descriptions of related circuits in other areas suggest that cortico-thalamo-cortical circuits may generally be organized primarily as recurrent loops.
Revisiting Parameters of Bioinspired Behavior Models in Group Foraging Modeling
Authors: Malyshev Alexander , Burgov Evgenii 
Published: February 2020

Using bioinspired models and methods is one of approaches for solving tasks of swarm robotics. In this paper one of such tasks, modeling of foraging, and it’s solving by creating analogues of social structures of ants and models of feeding behavior are considered. The most important characteristics of ants’ colonies for modeling were defined – individuals number in society and it’s structure, workers’ speed, a communication distance and working area size. Besides, existing experimental basis (a group of robots and a polygon) was estimated for a usage as a hardware platform for experiments. Several models of feeding behavior were considered: a model without foragers’ functions differentiation and a model with differentiation on active and passive ones. Active foragers look for resources by themselves, then they involve passive foragers; passive foragers are settled on a base, while are not involved in harvesting.
A set of finite state machines describe the behavior of agents: basic automatons (provide basic behavior functions) and a meta- automaton, that switches with some conditions an execution of basic automatons. Basic movements were tested on experimental basis. A complex test of models were conducted in a simulation program Kvorum. An analogue of real polygon was made in the program. Modeling consists of series of experiments for every model in which agents must harvest resources. Series differ from each other by number of agents. For models’ quality estimation a ratio of received energy to average obtaining time. Experiments settle that model with functions differentiation works more effective.