bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased plasma rifapentine concentrations associated with AADAC single nucleotide polymorphism in adults with tuberculosis
Authors: Weiner Marc , Gelfond Jon , Johnson-Pais Teresa L , Engle Melissa , Johnson John L , Whitworth William C , Bliven-Sizemore Erin , Nsubuga Pheona , Dorman Susan E , Savic Rada ,   the Pharmacokinetics/Pharmacodynamics Group of Tuberculosis Trials Consortium, Weiner Marc , Savic Rada , Whitworth William C , Engle Melissa , Dooley Kelly , Nsubuga Pheona , Ricaldi Jessica , Vernon Andrew 
Published: November 2020

Abstract

Background
Rifapentine exposure is associated with bactericidal activity against Mycobacterium tuberculosis, but high interindividual variation in plasma concentrations is encountered.

Objectives
To investigate a genomic association with interindividual variation of rifapentine exposure, SNPs of six human genes involving rifamycin metabolism (AADAC, CES2), drug transport (SLCO1B1, SLCO1B3) and gene regulation (HNF4A, PXR) were evaluated.

Methods
We characterized these genes in 173 adult participants in treatment trials of the Tuberculosis Trials Consortium. Participants were stratified by self-identified race (black or non-black), and rifapentine AUC from 0 to 24 h (AUC0–24) was adjusted by analysis of covariance for SNPs, rifapentine dose, sex, food and HIV coinfection. This study was registered at ClinicalTrials.gov under identifier NCT01043575.

Results
The effect on rifapentine least squares mean AUC0–24 in black participants overall decreased by –10.2% for AADAC rs1803155 G versus A allele (Wald test: P = 0.03; false discovery rate, 0.10). Black participants with one G allele in AADAC rs1803155 were three times as likely to have below target bactericidal rifapentine exposure than black participants with the A allele (OR, 2.97; 95% CI: 1.16, 7.58). With two G alleles, the OR was greater. In non-black participants, AADAC rs1803155 SNP was not associated with rifapentine exposure. In both black and non-black participants, other evaluated genes were not associated with rifapentine exposure (P &gt; 0.05; false discovery rate &gt; 0.10).

Conclusions
Rifapentine exposure in black participants varied with AADAC rs1803155 genotype and the G allele was more likely to be associated with below bactericidal target rifapentine exposure. Further pharmacogenomic study is needed to characterize the association of the AADAC rs1803155 with inadequate rifapentine exposure in different patient groups.
Spillovers and strategic interaction in immigration policies
Authors: Görlach Joseph-Simon , Motz Nicolas 
Published: November 2020

Abstract
Asylum policies are interdependent across countries: policy choices in one country can affect refugee flows into neighbouring countries and may provoke policy changes there, in an a priori unknown direction. We formulate a dynamic model of refugees’ location choices and of the strategic interaction among destinations that we fit to Syrian refugee migration to Europe. We find that south and southeastern European countries view recognition rates as strategic substitutes, whereas the same policies can be strategic complements in northern Europe. Our findings imply that regression frameworks which use cross-country variation to estimate the effects of recognition rates on immigration underestimate (overestimate) the effect if this policy is a strategic substitute (complement).
Short Persistence and Vector Susceptibility to Ficam 80WP (bendiocarb active ingredient) During Pilot Application of Indoor Residual Spraying in Burkina Faso, West Africa
Authors: Hien Aristide Sawdetuo , Soma Dieudonné Diloma , Somé Fabrice Anyirekun , Namountougou Moussa , Poda Serge Bèwadéyir , Ouédraogo Georges Anicet , Diabaté Abdoulaye , Dabiré Roch Kounbobr 
Published: November 2020

Abstract
Indoor residual spraying (IRS) was applied in addition to the use of long-lasting insecticidal nets in the South West in Burkina Faso, where Anopheles gambiae s.l. the major malaria vector was resistant to pyrethroids. This study was designed to evaluate the efficacy and residual life of bendiocarb (active ingredient) used for spraying on different wall surfaces (mud and cement). Cone bioassays were done monthly with the susceptible An. gambiae ‘Kisumu’ strain and the local wild populations to determine the duration for which insecticide was effective in killing mosquitoes. Cone bioassay data showed low efficacy and short persistence of bendiocarb applied on mud and cement walls, lasting 2 mo with the susceptible insectary strain and less than 1 mo with An. gambiae wild populations. In addition, WHO tube assays confirmed resistance of An. gambiae wild populations to 0.1% bendiocarb with mortality rates less than 80% in both study sites (sprayed and unsprayed sites). The pilot study of IRS with bendiocarb showed that the residual efficacy of bendiocarb was very short, and resistance to bendiocarb was confirmed in wild populations of An. gambiae s.l. Therefore, Ficam 80 WP was not suitable for IRS in this area due to the short residual duration related mainly to vectors resistance to bendiocarb. While waiting for innovative malaria control tool, alternative insecticide (organophosphate or neonicotinoid classes) or combinations of insecticides have to be used for insecticide resistance management in Burkina Faso.
Intraspecific differentiation in seed flooding tolerance ofEchinochloa crusgallivar.zelayensispopulation in shores of a giant reservoir along altitudinal gradients
Authors: Liu Songping , Lin Feng , Su Xiaolei , Ayi Qiaoli , Niu Hangang , Shi Shaohua , Wan Binna , Zeng Bo , Zhang Xiaoping 
Published: November 2020

AbstractAimsIn a large dam-regulated reservoir with regular hydrological pattern and strong flooding gradients across shore elevations, plants inhabiting in different shore elevations have to confront long-lasting flooding of differential intensities every year. Such persistent stress may lead to intraspecific differentiation of flooding tolerance in seeds. Echinochloa crusgalli var. zelayensis is a dominant annual plant in the shores of the Three Gorges Reservoir (TGR), which plays an important role in the shore vegetation. The objective of this study is to check whether intraspecific differentiation of seed flooding tolerance has occurred among E. crusgalli var. zelayensis populations in the TGR shores and whether such differentiation is associated with weak seed dispersal.MethodsWe collected seeds of E. crusgalli var. zelayensis from different populations in the TGR shores, and then placed them at four elevations in the shores flooded by reservoir impoundment. Parameters reflecting seed flooding tolerance including post-flooding percentage of intact seeds, seed germinability and seedling emergence rate were investigated for the seeds from different populations and undergoing flooding of different intensities. Floating time of seeds and speed of water level rise during impoundment were examined, and used to quantify dispersal potential of seeds in the shores of the TGR when flooded.Important FindingsBoth intact seed percentage and final seedling emergence rate after flooding significantly declined with increasing shore elevations where the seeds were collected, indicating that intraspecific differentiation in seed flooding tolerance has occurred among E. crusgalli var. zelayensis populations in the TGR shores after 7-year operation of the reservoir. The distance of seeds transported by rising water during reservoir impoundment was limited due to short-floating time of the seeds and relatively low speed of water level rise in the reservoir. This would be favourable to the development of intraspecific differentiation in seed flooding tolerance.
The successful use of collagenase for Ledderhose disease (plantar fibromatosis) in a paediatric patient: a case report
Authors: Mahmoud Arin , Kozhikunnath Arun , Buddhdev Pranai 
Published: November 2020

AbstractLedderhose disease is a connective tissue disorder involving proliferation of fibrous tissue in the plantar fascia of the foot. Histologically identical manifestations exist in the hand (Dupuytren’s contracture) and penis (Peyronie’s disease), and collagenase injections are approved as a treatment in both, however not in Ledderhose, where the treatment of choice remains surgical resection. Surgery is associated with high rates of recurrence and need for further surgery, so alternative therapies should be sought. Due to their histological and physiological similarities, it is likely that therapies useful in Dupuytren’s and Peyronie’s would be useful in Ledderhose. Two previous case reports investigating collagenase injections for Ledderhose disease in adults have shown conflicting results; this study demonstrates the efficacy of collagenase injections in a paediatric patient at 1-year follow-up.
Navigating the risks of flying during COVID-19: a review for safe air travel
Authors: Khatib Aisha N , Carvalho Anna-Maria , Primavesi Robert , To Kent , Poirier Vincent 
Published: November 2020

Abstract

Rationale for Review
With air travel restarting, there has been much discourse about the safety of flying during the pandemic. In travel medicine, risk assessment includes estimating baseline risk to the traveller, recognizing factors that may modify that risk, considering the role of interventions to decrease that risk and accounting for a traveller’s perception and tolerance of risk. The goals of this review are to identify the in-flight transmission risks of commercial air travel, provide recommendations about the risks of flying during the pandemic and propose strategies to mitigate the spread of COVID-19.

Key Findings
The airline industry has taken a layered approach to increase passenger safety through effective onboard ventilation, extended ventilation at the gate, boarding and deplaning strategies, improved aircraft disinfection and pre-flight screening such as temperature checks and COVID-19 testing. Proximity to an index case may contribute to the risk of transmission more than the seat type or location. The use of face masks has significantly reduced onboard transmission, and mandatory in-flight mask-wearing policies are being enforced. Innovations such as digital health passports may help standardize screening entry requirements at airports and borders, allowing for a safer return to travel.

Recommendations
In-flight transmission of SARS-CoV-2 is a real risk, which may be minimized by combining mitigation strategies and infection prevention measures including mandatory masking onboard, minimizing unmasked time while eating, turning on gasper airflow in-flight, frequent hand sanitizing, disinfecting high touch surfaces, promoting distancing while boarding and deplaning, limiting onboard passenger movement, implementing effective pre-flight screening measures and enhancing contact tracing capability. Assessing risk is a cornerstone of travel medicine. It is important to evaluate the multiple factors contributing to the cumulative risk of an individual traveller during the COVID-19 pandemic and to employ a multi-pronged approach to reduce that risk.
The role of CLAVATA signalling in the negative regulation of mycorrhizal colonization and nitrogen response of tomato
Authors: Wang Chenglei , Velandia Karen , Kwon Choon-Tak , Wulf Kate E , Nichols David S , Reid James B , Foo Eloise 
Published: November 2020

Abstract
Plants form mutualistic nutrient-acquiring symbioses with microbes, including arbuscular mycorrhizal fungi. The formation of these symbioses is costly, and plants employ a negative feedback loop termed autoregulation of mycorrhizae (AOM) to limit formation of arbuscular mycorrhizae (AM). We provide evidence for the role of one leucine-rich repeat receptor-like kinase (FAB), a hydroxyproline O-arabinosyltransferase enzyme (FIN), and additional evidence for one receptor-like protein (SlCLV2) in the negative regulation of AM formation in tomato. Reciprocal grafting experiments suggest that the FAB gene acts locally in the root, while the SlCLV2 gene may act in both the root and the shoot. External nutrients including phosphate and nitrate can also strongly suppress AM formation. We found that FAB and FIN are required for nitrate suppression of AM but are not required for the powerful suppression of AM colonization by phosphate. This parallels some of the roles of legume homologues in the autoregulation of the more recently evolved symbioses with nitrogen-fixing bacteria leading to nodulation. This deep homology in the symbiotic role of these genes suggests that in addition to the early signalling events that lead to the establishment of AM and nodulation, the autoregulation pathway might also be considered part of the common symbiotic toolkit that enabled plants to form beneficial symbioses.
λ And: a post-main-sequence wind from a solar-mass star
Authors: Ó Fionnagáin D , Vidotto A A , Petit P , Neiner C , Manchester IV W , Folsom C P , Hallinan G 
Published: November 2020

ABSTRACT
We investigate the wind of λ And, a solar-mass star that has evolved off the main sequence becoming a subgiant. We present spectropolarimetric observations and use them to reconstruct the surface magnetic field of λ And. Although much older than our Sun, this star exhibits a stronger (reaching up to 83 G) large-scale magnetic field, which is dominated by the poloidal component. To investigate the wind of λ And, we use the derived magnetic map to simulate two stellar wind scenarios, namely a ‘polytropic wind’ (thermally driven) and an ‘Alfven-wave-driven wind’ with turbulent dissipation. From our 3D magnetohydrodynamics simulations, we calculate the wind thermal emission and compare it to previously published radio observations and more recent Very Large Array observations, which we present here. These observations show a basal sub-mJy quiescent flux level at ∼5 GHz and, at epochs, a much larger flux density (&gt;37 mJy), likely due to radio flares. By comparing our model results with the radio observations of λ And, we can constrain its mass-loss rate $\dot{M}$. There are two possible conclusions. (1) Assuming the quiescent radio emission originates from the stellar wind, we conclude that λ And has $\dot{M} \simeq 3 \times 10^{-9}$ M⊙ yr −1, which agrees with the evolving mass-loss rate trend for evolved solar-mass stars. (2) Alternatively, if the quiescent emission does not originate from the wind, our models can only place an upper limit on mass-loss rates, indicating that $\dot{M} \lesssim 3 \times 10^{-9}$ M⊙ yr −1.
Calibrating the binary black hole population in nuclear star clusters through tidal disruption events
Authors: Fragione Giacomo , Perna Rosalba , Loeb Abraham 
Published: November 2020

ABSTRACT
As the sensitivity of gravitational wave (GW) instruments improves and new networks start operating, hundreds of merging stellar-mass black holes (SBHs) and intermediate-mass black holes (IMBHs) are expected to be observed in the next few years. The origin and distribution of SBH and IMBH binaries in various dynamical environments is a fundamental scientific question in GW astronomy. In this paper, we discuss ways tidal disruption events (TDEs) may provide a unique electromagnetic window into the assembly and merger of binary SBHs and IMBHs in nuclear star clusters (NSCs). We discuss how the host NSC mass and density and the slope of the BH mass function set the orbital properties and the masses of the binaries that undergo a TDE. For typical NSC properties, we predict a TDE rate of ∼10−6–10−7 yr−1 per galaxy. The light curve of TDEs in NSCs could be interrupted and modulated by the companion BH on the orbital period of the binary. These should be readily detectable by optical transient surveys such as the Zwicky Transient Facility and LSST.
Generation of gravitational waves and tidal disruptions in clumpy galaxies
Authors: Pestoni Boris , Bortolas Elisa , Capelo Pedro R , Mayer Lucio 
Published: November 2020

ABSTRACT
Obtaining a better understanding of intermediate-mass black holes (IMBHs) is crucial, as their properties could shed light on the origin and growth of their supermassive counterparts. Massive star-forming clumps, which are present in a large fraction of massive galaxies at z ∼ 1–3, are among the venues wherein IMBHs could reside. We perform a series of Fokker–Planck simulations to explore the occurrence of tidal disruption (TD) and gravitational wave (GW) events about an IMBH in a massive star-forming clump, modelling the latter so that its mass ($10^8 \, {\rm M}_{\odot}$) and effective radius (100 pc) are consistent with the properties of both observed and simulated clumps. We find that the TD and GW event rates are in the ranges of 10−6 to 10−5 and 10−8 to 10−7 yr−1, respectively, depending on the assumptions for the initial inner density profile of the system (ρ ∝ r−2 or ∝ r−1) and the initial mass of the central IMBH (105 or $10^3\, {\rm M}_{\odot}$). By integrating the GW event rate over z = 1–3, we expect that the Laser Interferometer Space Antenna will be able to detect ∼2 GW events per year coming from these massive clumps; the intrinsic rate of TD events from these systems amounts instead to a few 103 per year, a fraction of which will be observable by e.g. the Square Kilometre Array and the Advanced Telescope for High Energy Astrophysics. In conclusion, our results support the idea that the forthcoming GW and electromagnetic facilities may have the unprecedented opportunity of unveiling the lurking population of IMBHs.
Properties of von Zeipel–Lidov–Kozai oscillations in triple systems at the quadrupole order: relaxing the test particle approximation
Authors: Hamers Adrian S 
Published: November 2020

ABSTRACT
Von Zeipel–Lidov–Kozai (ZLK) oscillations in hierarchical triple systems have important astrophysical implications such as triggering strong interactions and producing, e.g. Type Ia supernovae and gravitational wave sources. When considering analytic properties of ZLK oscillations at the lowest (quadrupole) expansion order, as well as complications due to higher order terms, one usually assumes the test particle limit, in which one of the bodies in the inner binary is massless. Although this approximation holds well for, e.g. planetary systems, it is less accurate for systems with more comparable masses such as stellar triples. Although non-test-particle effects are usually taken into account in numerical simulations, a more analytic approach focusing on the differences between the test particle and general case (at quadrupole order) has, to our knowledge, not been presented. Here, we derive several analytic properties of secular oscillations in triples at the quadruple expansion order. The latter applies even to relatively compact triples, as long as the inner bodies are similar in mass such that octupole-order effects are suppressed. We consider general conditions for the character of the oscillations (circular versus librating), minimum and maximum eccentricities, and time-scales, all as a function of $\gamma \equiv (1/2) \, L_1/G_2$, a ratio of inner-to-outer orbital angular momenta variables (γ = 0 in the test particle limit). In particular, eccentricity oscillations are more effective at retrograde orientations for non-zero γ; assuming zero initial inner eccentricity, the maximum eccentricity peaks at $\cos (i_{\mathrm{rel},0}) = -\gamma$, where $i_{\mathrm{rel},0}$ is the initial relative inclination. We provide a python script that can be used to quickly compute these properties.
Parametric instability in a free-evolving warped protoplanetary disc
Authors: Deng Hongping , Ogilvie Gordon I , Mayer Lucio 
Published: November 2020

ABSTRACT
Warped accretion discs of low viscosity are prone to hydrodynamic instability due to parametric resonance of inertial waves as confirmed by local simulations. Global simulations of warped discs, using either smoothed particle hydrodynamics or grid-based codes, are ubiquitous but no such instability has been seen. Here, we utilize a hybrid Godunov-type Lagrangian method to study parametric instability in global simulations of warped Keplerian discs at unprecedentedly high resolution (up to 120 million particles). In the global simulations, the propagation of the warp is well described by the linear bending-wave equations before the instability sets in. The ensuing turbulence, captured for the first time in a global simulation, damps relative orbital inclinations and leads to a decrease in the angular momentum deficit. As a result, the warp undergoes significant damping within one bending-wave crossing time. Observed protoplanetary disc warps are likely maintained by companions or aftermath of disc breaking.
LnCeCell: a comprehensive database of predicted lncRNA-associated ceRNA networks at single-cell resolution
Authors: Wang Peng , Guo Qiuyan , Hao Yangyang , Liu Qian , Gao Yue , Zhi Hui , Li Xin , Shang Shipeng , Guo Shuang , Zhang Yunpeng , Ning Shangwei , Li Xia 
Published: November 2020

Abstract
Within the tumour microenvironment, cells exhibit different behaviours driven by fine-tuning of gene regulation. Identification of cellular-specific gene regulatory networks will deepen the understanding of disease pathology at single-cell resolution and contribute to the development of precision medicine. Here, we describe a database, LnCeCell (http://www.bio-bigdata.net/LnCeCell/ or http://bio-bigdata.hrbmu.edu.cn/LnCeCell/), which aims to document cellular-specific long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) networks for personalised characterisation of diseases based on the ‘One Cell, One World’ theory. LnCeCell is curated with cellular-specific ceRNA regulations from &gt;94 000 cells across 25 types of cancers and provides &gt;9000 experimentally supported lncRNA biomarkers, associated with tumour metastasis, recurrence, prognosis, circulation, drug resistance, etc. For each cell, LnCeCell illustrates a global map of ceRNA sub-cellular locations, which have been manually curated from the literature and related data sources, and portrays a functional state atlas for a single cancer cell. LnCeCell also provides several flexible tools to infer ceRNA functions based on a specific cellular background. LnCeCell serves as an important resource for investigating the gene regulatory networks within a single cell and can help researchers understand the regulatory mechanisms underlying complex microbial ecosystems and individual phenotypes.