bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of Nutrition Automation on Lactuca Sativa NFT Hydroponic Systems
Authors: Saputro Joko Slamet , Latifa Ulinnuha , Ramelan Agus 
Published: May 2020

<p class="Abstract">This research focus on preserved nutrition on lettuce plants, as well as automation of other parameters that affect plant growth in NFT type hydroponic systems such as temperature, water acidity (pH), water level and light intensity. The automation of this hydroponic system includes the provision of nutrients according to the needs of plants by utilizing EC sensors, keeping the temperature of the water in accordance with plant specifications as well as water levels that are maintained.<em></em></p><p class="Keywords"> </p>
Les biofictions à l’ère du numérique, ou profil de l’auteur posté par soi-même : les hypertextes d’Alain Farah et d’Alain Beaulieu
Authors: Pruteanu Simona Emilia 
Published: May 2020

Visant à envisager les (nouveaux) objets de l’écrivain à l’ère numérique, ce travail prend pour exemple le cas des deux écrivains et professeurs en création littéraire québécois, Alain Farah et Alain Beaulieu. Cette étude de leurs profils numériques démontre comment le réel, le potentiel et la fiction s’imbriquent dans les sphères publiques, privées et académiques investies par le statut d’auteur assumé par les deux écrivains. L’investissement médiatique des écrivains a pour résultat l’apparition de nouvelles formes de paratexte tout en changeant les modalités de partage entre auteur et son public. L’article suit aussi les modalités de « mise en scène du soi » en tenant compte de la citation de l’artiste allemand Joseph Beuys qu’on retrouve sur les pages sociales d’Alain Farah aussi bien que dans ses entretiens : « Je souhaiterais m’en tenir à cela aussi longtemps que ce m’est possible : jouer encore et encore ce rôle, être tout ce qu’on peut dire de moi. »
Objets trouvés d’une reprouvée : les objets d’écriture de Louise Michel en Nouvelle-Calédonie
Authors: Narayana Valérie 
Published: May 2020

Ce travail examine la correspondance d’exil de Louise Michel et y recense les objets qui permettent à la déportée de poursuivre ses projets d’écriture en Nouvelle-Calédonie​. Ces quelques possessions rendent manifestes les conditions de précarité dans lesquelles écrit l’ancienne Communarde. Les lettres, en plus de montrer la fortune de ces objets, témoignent du minimalisme radical de la militante. Cette qualité explique largement l’ascendant que Michel exerce sur ses camarades exilés avec qui elle partage biens et écrits. Parmi ces déportés, l’on compte Henry Bauër, fils naturel d’Alexandre Dumas. La singularité du caractère de Louise Michel éclaire également la correspondance entretenue avec Victor Hugo. En plus de vers envoyés au poète, Michel expédie des objets naturels, sortes d’emblèmes de son regard sur le monde matériel. Le tout est fragmentaire, résultat des pressions de la surveillance et des remous politiques; bref, ces textes épistolaires sont à l’image de la vie mouvementée de l’auteure.
Valoración de una intervención de fisioterapia acuática en niños con parálisis cerebral mediante la gross motor function measure. Un estudio de casos
Authors: Latorre García Julio , Rodríguez Doncel María Luisa , Sánchez López Antonio Manuel , Pozuelo Calvo Rocio , Aguilar Cordero María José 
Published: May 2020

Introducción: El presente estudio, parte de una revisión bibliográfica anterior sobre las técnicas de tratamiento en piscina para los pacientes afectados de Parálisis Cerebral Infantil (PC). Al no encontrar diferencias significativas entre los distintos métodos y técnicas utilizados, diseñamos un programa de ejercicios según el modelo del desarrollo psicomotor del niño sano, implementándolo y valorando su eficacia en el tratamiento de personas con esta patología haciendo un uso de la hidroterapia orientado hacia los aspectos estructurales, funcionales y sociales en el proceso global de la rehabilitación.
Objetivos: El objetivo de este estudio es valorar la evolución que se produce en la función motora gruesa en niños afectados de PC, después de seis meses de tratamiento.
Método: Se trata de un estudio longitudinal prospectivo sobre 12 pacientes con edades comprendidas entre 18 y 33 meses al comienzo, 9 niños y 3 niñas. El protocolo de tratamiento consiste en una sesión semanal de 30 minutos de los cuales, 20 se realizan íntegramente en piscina. Se evaluó mediante la Escala validada Gross Motor Function Measure (GMFM) antes de realizar hidroterapia y a los seis meses de iniciar la intervención. No se ha utilizado grupo control debido a que la diversa sintomatología propia de esta patología lo desaconseja. Cada paciente es su propio control entre el pre y post-test.
Resultados: Se observa una mejoría, estadísticamente significativa, en la escala global GMFM y en aspectos específicos de las subescalas: a) Tumbado y rodando, b) Sentado, c) Gateando y de rodillas, d) de pie, e) Andando, Corriendo, saltando.
Conclusiones: La hidroterapia promueve el desarrollo de habilidades motoras gruesas en niños afectados por PC. También contribuye a un desarrollo positivo en la curva GMFM normal y una mejora posterior a la intervención en los percentiles correspondientes.
Palabras clave: Hidroterapia, Quinesiología Aplicada, Encefalopatía crónica, Enfermedades del recién nacido.
First Insights on Value-Based Healthcare of Elders Using ICHOM Older Person Standard Set Reporting
Authors: Lee Wei-Ju , Peng Li-Ning , Lin Chi-Hung , Lin Shinn-Zong , Loh Ching-Hui , Kao Sheng-Lun , Hung Tzu-Shing , Chang Chia-Yun , Huang Chun-Feng , Tang Ting-Ching , Chen Liang-Kung 
Published: May 2020

Abstract
Background: Clinical guidelines for specific conditions fragment care provision for elders. The International Consortium for Health Outcomes Measurement (ICHOM) has developed a global standard set of outcome measures for comprehensive assessment of older persons. The goal of this study was to report value-based health metrics in Taiwan using this ICHOM toolset.Methods: The cross-sectional study of baseline data excerpted from a prospective longitudinal cohort, which recruited people ≥65 years old with ≥3 chronic medical conditions between July and December 2018. All participants received measurements of physical performance, anthropometric characteristics, health-related behaviors, Charlson Comorbidity Index, and Montreal Cognitive Assessment. The ICHOM toolset comprises three tiers: 1 includes frailty and having chosen a preferred place of death; 2 includes polypharmacy, falls, and participation in decision-making; and 3 includes loneliness, activities of daily living, pain, depression, and walking speed. These items were converted into a 0–10 point value-based healthcare score, with high value-based health status defined as ≥8/10 points. Results: Frequencies of individual ICHOM indicators were: frail 11.7%, chose preferred place of death 14.4%, polypharmacy 31.5%, fell 17.1%, participated in decision-making 81.6%, loneliness 26.8%, limited activities of daily living 22.4, pain 10.4%, depressed mood 13.0%, and slowness 38.5%. People with high disease severity (OR 0.40, 95% CI 0.21–0.76, p=0.005) or cognitive impairment (OR 0.49, 95%CI 0.27–0.87, p=0.014) were less likely to have high value-based healthcare status. Conclusions: The ICHOM Standard Set Older Person health outcome measures provide an opportunity to shift from a disease-centric medical paradigm to whole person-focused goals. This study identified advanced age, chronic disease and cognitive impairment as important barriers to achieving high value-based healthcare status.﻿
The prognostic values of m6A RNA methylation regulators in Uveal melanoma
Authors: Tang Jing , Wan Qi , Lu Jianqun 
Published: May 2020

Abstract
Background: The aim of this study was to identify gene signatures and prognostic values of m6A methylation regulators in uveal melanoma (UM).Methods: The RNA sequencing dataset and corresponding clinical information were downloaded from TCGA and GEO database. Based on the expression of m6A RNA methylation regulators, the patients were further clustered into different groups by applying the “ClassDiscovery” algorithm. Best survival analysis was performed to select prognostic m6A regulators and multivariate cox regression analysis was applied to constructed m6A regulators signature. The association between mutations and m6A regulators was assessed by Kruskal−Wallis tests and clinical characteristics were examined by using chi-square test.Results: Totally, we identified two molecular subtypes of UM (C1/2) by applying consensus clustering to m6A RNA methylation regulators. In contrast to the C1 subtype, the C2 subtype associates with a better prognosis, have higher percentage of subtype 1 and lower percentage of Monosomy 3 which have been regarded as the well established prognostic markers for UM. The malignant hallmarks of mTORC1 signaling, oxidative phosphorylation, interferon-a response and apoptosis signaling are also significantly enriched in the C1 subtype. Moreover, a 3-m6A regulators signature was constructed by multivariate cox regression analysis method, which closely correlated with chromosome 3 status, subtype 1 of UM and can robustly predict patients’ overall survival time.Conclusions: m6A RNA methylation regulators take a crucial role in the potential malignant progression and prognostic value of UM and might be regarded as a new promising biomarker for UM prognosis and treatment strategy development.
Effect Of Smoking On Treatment Outcome Among Tuberculosis Patients In Malaysia; A Multicenter Study
Authors: Khan Amer Hayat , Sulaiman Syed Azhar Syed , Hassali Mohamed Azmi , Khan Kashif Ullah , Ming Long Chiau , Mateen Umer , Malik Obaid Ullah 
Published: May 2020

Abstract
Background: Smoking plays a key role in the development of tuberculosis (TB) infection and is also a predictor of poor TB treatment prognosis and outcomes. The current study was conducted to determine the prevalence of smoking and to assess the effects of smoking on treatment outcomes among TB patients. Methods: A multi-center retrospective study design was used to collect data from TB patients in four different states of Malaysia, namely Penang, Sabah, Sarawak, and Selangor. The study included medical records of TB patients admitted to the selected hospitals in the period from January 2006 to March 2009. Medical records with incomplete data were not included. Patient demographics and clinical data were collected using a validated data collection form. Results: Of all patients with TB (9337), the prevalence of smokers was 4313 (46.2%). Among smokers, 3584 (83.1%) were associated with pulmonary TB, while 729 (16.9%) were associated with extrapulmonary TB. Male gender (OR= 1.43, 95% CI 1.30-1.58), Chinese ethnicity (OR= 1.23, 95% CI 1.02-1.49), Sarawak indigenous ethnicity (OR= 0.74, 95% CI 0.58-0.95), urban residents (OR= 1.46, 95% CI 1.33-1.61), employed individuals (OR= 1.21, 95% CI 1.09-1.34), alcoholics (OR= 4.91, 95% CI 4.04-5.96), drug abusers (OR= 7.43, 95% CI 5.70-9.60) and presence of co-morbid condition (OR= 1.27, 95% CI 1.16-1.40) all showed significant association with smoking habits. This study found that 3236 (75.0 %) patients were successfully treated in the smokers' group, while 4004 (79.7 %) patients were non-smokers. The proportion of deaths (6.6%, n=283), defaulters (6.6%, n=284) and treatment interruptions (4.7%, n=204) was higher in the smokers' group.Conclusions: Smoking has a strong influence on TB and is a major barrier towards treatment success (OR= 0.76, 95% CI 0.69-0.84, p< 0.001). Therefore, the findings indicate that smoking cessations are an effective way to decrease treatment failure and drug resistance.
Setting up a nurse-led model of care for management of Hypertension and Diabetes Mellitus in a high HIV prevalence context in rural Zimbabwe: a descriptive study
Authors: Frieden Marthe Marie , Zamba Blessing , Mukumbi Nisbert , Mafaune Patron Titsha , Makumbe Brian , Irungu Elizabeth , Moneti Virginia , Isaakidis Petros , Garone Daniela , Prasai Madhu Janina 
Published: May 2020

Abstract
Background: In the light of the increasing burden of non-communicable diseases (NCDs) on health systems in low- and middle-income countries, particularly in Sub-Saharan Africa, context-adapted, cost-effective service delivery models are now required as a matter of urgency. We describe the experience of setting up and organising a nurse-led Diabetes Mellitus (DM) and Hypertension (HTN) model of care in rural Zimbabwe, a low-income country with unique socio-economic challenges and a dual disease burden of HIV and NCDs. Methods: Mirroring the HIV experience, we designed a conceptual framework with 9 key enablers: decentralization of services, integration of care, simplification of management guidelines, mentoring and task-sharing, provision of affordable medicines, quality assured laboratory support, patient empowerment, a dedicated monitoring and evaluation system, and a robust referral system. We selected 9 primary health care clinics (PHC) and two hospitals in Chipinge district and integrated DM and HTN either into the general out-patient department, pre-existing HIV clinics, or an integrated chronic care clinic (ICCC). We provided structured intensive mentoring for staff, using simplified protocols, and disease-specific education for patients. Free medication with differentiated periodic refills and regular monitoring with point of care (POC) glycosylated haemoglobin (HbA1c) were provided. Results: Nurses in 7 PHC facilities and one hospital developed sufficient knowledge and skills to diagnose, initiate treatment and monitor DM and HTN patients, and 3094 patients were registered in the programme (188 with DM only, 2473 with HTN only, 433 with both DM and HTN). Major lessons learned from our experience include: the value of POC devices in the management of diabetes; the pressure on services of the added caseload, exacerbated by the availability of free medications in supported health facilities; and the importance of leadership in the successful implementation of care in health facilities.Conclusion: Our experience demonstrates a model for nurse-led decentralized integrated DM and HTN care in a high HIV prevalence rural, low-income context. Developing a context-adapted efficient model of care is a dynamic process. We present our lessons learned with the intention of sharing experience which may be of value to other public health programme managers.
The level of bilirubin and the risk of ischemic stroke: a systematic review and dose-response meta-analysis of real-world studies
Authors: Wang Xiao , Zhou Yang , Ye Xiaofei , Liu Fangchen , Zhu Xi , Wu Danhong , Zhong Ping 
Published: May 2020

Abstract
Background: Bilirubin, a marker of hepatic and hematological diseases in clinical practice, is not only a waste end-product but also an antioxidant that may protect against diseases associated with oxidative stress. Numerous epidemiological studies have shown an inverse relationship between the serum total bilirubin (TBIL) level and the risk of ischemic stroke (IS). However, markedly elevated TBIL levels may exert neurotoxic effects. Based on this, we conducted a dose-response meta-analysis to quantify the relationship between blood TBIL and IS as well as between TBIL and all types of stroke (AS) in the physiological range of bilirubin.Methods: PubMed, Embase, Web of Science, and Cochrane Central databases were searched up to March 2019. Additional studies were identified by reviewing references and contacting authors. Categorical and dose-response meta-analyses were performed to quantify the relationship between TBIL and IS. The primary outcome was ischemic stroke, and the secondary outcome was all types of stroke.Results: Nine observational studies (seven publications) involving 110,032 participants and 3710 stroke cases were included for analysis. The average OR of IS for every 1 µmol/L increment in TBIL level was 0.978 (95% CI: 0.957–0.999). The summary OR of AS for every 1 µmol/L increment in TBIL level was 0.974 (95% CI: 0.956–0.992). Subgroup analysis based on gender showed a negative dose-response relationship between the circulating TBIL level and IS or AS in males, but not in females.Conclusions: The present study found a negative dose-response relationship between the circulating TBIL level and the risk of IS or AS within physiologic range of serum TBIL in males. Moderately elevated blood TBIL levels might be associated with a diminished prevalence of IS. Every 1 µmol/L increment in serum TBIL level was associated with a 2.2% decrease in the risk of IS and a 2.6% decrease in the risk of AS. However, due to the limitations in the number of included studies and their quality, large-scaled prospective cohort studies are needed to confirm the conclusion of the current analysis.Trial registration: This study was registered at PROSPERO (https://www.crd. york.ac.uk/PROSPERO/[CRD42017075988]).
Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats
Authors: Vichaya Elisabeth G. , Malik Sajida , Sominsky Luba , Ford Bianca G. , Spencer Sarah J. , Dantzer Robert 
Published: May 2020

Abstract
Background: Production of inflammatory mediators by reactive microglial cells in the brain is generally considered the primary mechanism underlying the development of symptoms of sickness in response to systemic inflammation.Methods: Depletion of microglia was achieved in C57BL/6 mice by chronic oral administration of PLX5622, a specific antagonist of colony stimulating factor-1 receptor, and in rats by a knock-in model in which the diphtheria toxin receptor was expressed under the control of the endogenous fractalkine receptor (CX3CR1) promoter sequence. After successful microglia depletion, mice and rats were injected with a sickness-inducing dose of lipopolysaccharide according to a 2 (depletion versus control) x 2 (LPS versus saline) factorial design. Sickness was measured by body weight loss and decreased locomotor activity in rats and mice, and reduced voluntary wheel running in mice. Results: Chronic administration of PLX5622 in mice and administration of diphtheria toxin to knock-in rats depleted microglia and peripheral tissue macrophages. However, it did not abrogate the inducible expression of proinflammatory cytokines in the brain in response to LPS and even exacerbated it for some of the cytokines. In accordance with these neuroimmune effects, LPS-induced sickness was not abrogated, rather it was exacerbated when measured by running wheel activity in mice. Conclusions: These findings reveal that the sickness-inducing effects of acute inflammation can develop independently of microglia activation.
No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study
Authors: Hagberg Guri , Ihle-Hansen Hege , Fure Brynjar , Thommessen Bente , Ihle-Hansen Håkon , Øksengård Anne Rita , Beyer Mona K. , Wyller  , Müller Ebba Gløersen , Pendlebury Sarah T. , Selnes Per 
Published: May 2020

Abstract
Background: Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI is unclear. We hypothesize that amyloid deposition, measured with Flutemetamol (18F-Flut) positron emission tomography (PET), is common in seven-year stroke survivors diagnosed with CI and, further, that quantitatively assessed 18F-Flut-PET uptake after seven years correlates with amyloid-β peptide (Aβ₄₂) levels in cerebrospinal fluid (CSF) at one year, and with measures of neurodegeneration and cognition at seven years post-stroke. Methods: 208 patients with first-ever stroke or transient Ischemic Attack (TIA) without pre-existing CI were included during 2007 and 2008. At one- and seven-years post-stroke, cognitive status was assessed, and categorized into dementia, mild cognitive impairment or normal. Etiologic sub-classification was based on magnetic resonance imaging (MRI) findings, CSF biomarkers and clinical cognitive profile. At seven years, patients were offered 18F-Flut-PET, and amyloid-positivity was assessed visually and semi-quantitatively. The associations between 18F-Flut-PET standardized uptake value ratios (SUVr) and measures of neurodegeneration (medial temporal lobe atrophy (MTLA), global cortical atrophy (GCA)) and cognition (Mini-Mental State Exam (MMSE), Trail-making test A (TMT-A)) and CSF Aβ₄₂ levels were assessed using linear regression. Results: In total, 111 patients completed 7-year follow-up, and 26 patients agreed to PET imaging, of whom 13 had CSF biomarkers from one year. Thirteen out of 26 patients were diagnosed with CI seven years post-stroke, but only one had visually assessed amyloid positivity. CSF Aβ₄₂ levels at one year, MTA grade, GCA scale, MMSE score or TMT-A at seven years did not correlate with 18F-Flut-PET SUVr in this cohort.Conclusions: Amyloid binding was not common in 7-year stroke survivors diagnosed with CI. Quantitatively assessed, cortical amyloid deposition did not correlate with other measures related to neurodegeneration or cognition. Therefore, amyloid pathology may not be a key mediator of neurodegeneration seven years post-stroke.Trial registration: Clinicaltrials.gov (NCT00506818). July 23, 2007. Inclusion from February 2007, randomization and intervention from May 2007 and trial registration in July 2007.
Clinical, Functional and Radiographic Outcomes of Primary Total Hip Arthroplasty between Direct Anterior Approach and Posterior Approach: a Systematic Review and Meta-analysis
Authors: Peng Linbo , Zeng Yi , Wu Yuangang , Zeng Junfeng , Liu Yuan , Shen Bin 
Published: May 2020

Abstract
Background: The purpose of this systematic review and meta-analysis was to compare the direct anterior approach and posterior approach for primary total hip arthroplasty in terms of the clinical, functional and radiographic outcomes.Methods: We searched the PubMed and EMBASE databases and Cochrane Library from their inception to November 1, 2019. We searched for previously published articles and meta-analyses of randomized controlled trials.Results: A total of 7 randomized controlled trials with 600 participants met the inclusioncriteria. Among these patients, 301 and 299 were included in the DAA and PA groups, respectively. The DAA was associated with a longer surgery by a mean duration of 13.74 min (95% CI 6.88 to 20.61, p < 0.0001, I2=93%). The postoperative early functional outcomes were significantly better in the DAA group than in the PA group, such as the Visual Analogue Scale (VAS) score at 1 day postoperatively (MD=-0.65, 95% CI -0.91 to -0.38, p < 0.00001, I2=0%), VAS score at 2 days postoperatively (MD=-0.67, 95% CI -1.34 to -0.01, p =0.05, I2=88%) and Harris Hip Score (HHS) at 6 weeks postoperatively (MD=6.05, 95% CI 1.14 to 10.95, p =0.02, I2=52%). There was no significant difference between the DAA and PA groups in the length of the incision, hospital length of stay (LOS), blood loss, transfusion rates or complication rates. We found no significant difference between the two groups regarding late functional outcomes, such as the VAS score at 12 months postoperatively or the HHS scores at 3, 6, and 12 months postoperatively. A significant difference in the radiographic outcomes was not detected.Conclusions: The DAA requires a longer surgery time than does the PA in primary total hip arthroplasty. The DAA yields better early functional recovery than does the PA. There was no significant difference between the two groups in terms of other clinical, complication-related, late functional or radiographic outcomes. The evidence on the superiority of the DAA is insufficient and needs to be studied further.