bluuebunny/crossref_metadata_2025_split huggingface dataset:
Funktionelle Ergebnisse nach transmandibulärer Resektion und primärer Radiochemotherapie bei fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen
Authors: Knopf A. , Mansour N. , Hofauer B. , Johnson F. , Bier H. , Wakonig F. , Teutsch S. 
Published: September 2020

Zusammenfassung
Ziel der Arbeit
In dieser Studie wurden die funktionellen Ergebnisse nach transmandibulärer Resektion und Rekonstruktion mittels mikrovaskulär anastomosiertem Radialistransplantat (TMR+Tx) gegenüber einer primären Radiochemotherapie (pRCT) bei fortgeschrittenen orophayngealen Plattenepithelkarzinomen (OPSCC) verglichen.

Methoden
Es erfolgte ein Vergleich zwischen 50 OPSCC-Patienten mit TMR+Tx und 50 OPSCC-Patienten mit pRCT. Die Wasserschluckzeit war als primärer Endpunkt definiert. Der Saxon-Test, die maxillomandibuläre Distanz, der Mallampati-Score, der Quotient aus Körpergröße zu Gewicht, eine nasale Penetration, das Vorhandensein einer Ernährungssonde/Tracheostomie sowie 4 validierte Fragebögen (Visuelle Analogskala zur Mundtrockenheit, Sicca VAS; MD Anderson Dysphagia Inventory, MDADI; Voice Handicap Index, VHI; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire – Head and Neck Cancer – 35 Items, QLQ-H&N35) dienten als sonstige Endpunkte zur Beurteilung der Funktion und Lebensqualität.

Ergebnisse
Die Gesamtkohorte an operierten Patienten zeigte eine erhöhte Rate an nasaler Penetration (p < 0,0001), was mit einer verlängerten Wasserschluckzeit verbunden war (p < 0,05). Durch eine modifizierte Rekonstruktion des Weichgaumens wurde die nasale Penetration in der chirurgisch therapierten Gruppe im Vergleich zur klassischen Rekonstruktion signifikant reduziert (p = 0,0001). Patienten mit pRCT litten signifikant stärker an einer Xerostomie (Saxon-Test) als Patienten nach TMR+Tx und Adjuvanz (p = 0,001). In den Fragebögen zur Funktionalität und Lebensqualität zeigte sich kein Unterschied zwischen den Gruppen.

Schussfolgerung
Die TMR+Tx mit modifizierter Rekonstruktion und adjuvante Therapie zeigte gegenüber der pRCT vergleichbare funktionelle Ergebnisse.
Interleukin 15 and Eotaxin correlate with the outcome of breast cancer patients vice versa independent of CTC status
Authors: Vilsmaier Theresa , Heidegger Helene Hildegard , Schröder Lennard , Trapp Elisabeth , zehni Alaleh Zati , Rack Brigitte , Janni Wolfgang , Mahner Sven , Weissenbacher Tobias , Jeschke Udo , Mumm Jan-Niclas ,   SUCCESS Study Group, Vilsmaier Theresa , Heidegger Helene Hildegard , Schröder Lennard 
Published: September 2020

AbstractBackgroundCirculating tumor cells (CTC) in the peripheral blood in women with breast cancer has been found to be an indicator of prognosis before the start of systemic treatment. The aim of this study is the assessment of specific cytokine profiles as markers for CTC involvement that could act as independent prognostic markers in terms of survival outcome for breast cancer patients.MethodsPatients selected for this study were defined as women with breast cancer of the SUCCESS study. A total of 200 patients’ sera were included in this study, 100 patients being positive for circulating tumor cells (CTC) and 100 patients being CTC negative. The matching criteria were histo-pathological grading, lymph node metastasis, hormone receptor status, TNM classification, and patient survival. Commercial ELISA with a multi cytokine/chemokine array was used to screen the sera for Interleukin 15 (IL-15) and eotaxin.ResultsStatistically significant concentrations were exposed for IL-15 levels regardless of the CTC-Status, lymph node involvement, or hormone receptor status. Significantly enhanced serum IL-15 concentrations were observed in those patients with worse overall survival (OS) and disease-free survival (DFS). Elevated serum concentrations of IL-15 significantly correlate with patients diagnosed with Grade 3 tumor and worse OS. In contrast, patients with a Grade 3 tumor with a favourable OS and DFS demonstrated significantly decreased IL-15 values. The CTC negative patient subgroup with a favourable OS and DFS, showed statistically significant elevated eotaxin values.ConclusionThese findings suggest a potential functional interaction of increased IL-15 concentrations in the peripheral blood of patients with a worse OS and DFS, regardless of prognostic factors at primary diagnosis. The increased levels of the chemokine eotaxin in CTC negative patients and a favourable OS and DFS, on the other hand, suggest that the overexpression inhibits CTCs entering the peripheral blood, thus emphasizing a significant inhibition of circulation specific metastasis. To sum up, IL-15 could be used as an independent prognostic marker in terms of survival outcome for breast cancer patients and used as an early indicator to highlight high-risk patients and consequently the adjustment of cancer therapy strategies.
The model structure of the copper-dependent ammonia monooxygenase
Authors: Musiani Francesco , Broll Valquiria , Evangelisti Elisa , Ciurli Stefano 
Published: September 2020

AbstractAmmonia monooxygenase is a copper-dependent membrane-bound enzyme that catalyzes the first step of nitrification in ammonia-oxidizing bacteria to convert ammonia to hydroxylamine, through the reductive insertion of a dioxygen-derived O atom in an N–H bond. This reaction is analogous to that carried out by particulate methane monooxygenase, which catalyzes the conversion of methane to methanol. The enzymatic activity of ammonia monooxygenase must be modulated to reduce the release of nitrogen-based soil nutrients for crop production into the atmosphere or underground waters, a phenomenon known to significantly decrease the efficiency of primary production as well as increase air and water pollution. The structure of ammonia monooxygenase is not available, rendering the rational design of enzyme inhibitors impossible. This study describes a successful attempt to build a structural model of ammonia monooxygenase, and its accessory proteins AmoD and AmoE, fromNitrosomonas europaea, taking advantage of the high sequence similarity with particulate methane monooxygenase and the homologous PmoD protein, for which crystal structures are instead available. The results obtained not only provide the structural details of the proteins ternary and quaternary structures, but also suggest a location for the copper-containing active site for both ammonia and methane monooxygenases, as well as support a proposed structure of a CuA-analogue dinuclear copper site in AmoD and PmoD.Graphic abstract
Non-programmed gait generation of quadruped robot using pulse-type hardware neuron models
Authors: Takei Yuki , Morishita Katsuyuki , Tazawa Riku , Katsuya Koichi , Saito Ken 
Published: September 2020

AbstractIn this paper, the authors will propose the active gait generation of a quadruped robot. The theory that quadruped animals unconsciously generate gaits by some system based on neural networks in the spinal cord is widely accepted. However, how biological neurons or neural networks can generate gaits is not clear. To clarify the gait generation method, one of the solutions is using the neuron model similar to the biological neuron. We developed the quadruped robot system using self-inhibited pulse-type hardware neuron models (P-HNMs), which can output the electrical activity similar to those of biological neurons. The P-HNMs consist of the cell body model and the inhibitory synaptic model. The cell body model periodically outputs pulsed voltages; the inhibitory synaptic model inhibits the pulsed voltages. The pulse period can change by varying the synaptic weight control voltage applied to the P-HNMs. We varied the synaptic weight control voltage according to the pressure on the robot’s toes. Also, we changed the angle of the robot’s joints by a constant angle each time the P-HNMs output a pulse. As a result of the walking experiment, we confirmed that the robot generates walk gait and trot gait according to the moving speed. Also, we clarified the process by which the robot actively generates gaits from the upright state. These results show that animals may not use many biological neurons to generate gaits. Furthermore, the results suggest the possibility of realizing simple and bio-inspired robot control.
Preparation of cellulose-rich membranes from wood: effect of wood pretreatment process on membrane performance
Authors: Lopatina Anastasiia , Anugwom Ikenna , Esmaeili Mohammadamin , Puro Liisa , Virtanen Tiina , Mänttäri Mika , Kallioinen Mari 
Published: September 2020

AbstractIn this study cellulose-rich membranes were fabricated from untreated and treated hardwood biomass solutions in 1-ethyl-3-methylimidazolium acetate ([Emim][OAc])—dimetylsulfoxide (DMSO) system via wet phase separation. Wood treatment methods aimed to get purified cellulose fraction of wood. Treatment sequence was as followed: deep eutectic solvent pretreatment, sodium chlorite bleaching, and alkaline treatment. Resulted biomass after each treatment step was characterized by chemical composition and crystalline fraction content. Flat-sheet membranes were produced from biomass samples after each treatment step. Characterization of membranes included measurements of pure water permeability and (poly)ethyleneglycol 35 kDa retention, Fourier-transform infrared and Raman spectroscopy, X-ray diffraction measurements and thermogravimetric analysis. The study revealed that it was possible to fabricate membrane from untreated wood as well as from wood biomass after each of treatment steps. The resulted membranes differed in chemical composition and filtration performance. Membrane prepared directly from untreated wood had the highest permeability, the lowest retention; and the most complex chemical composition among others. As treatment steps removed lignin and hemicelluloses from the wood biomass, the corresponding membranes became chemically more homogeneous and showed increased retention and decreased permeability values.
The Hardest Paradox for Closure
Authors: Smith Martin 
Published: September 2020

AbstractAccording to the principle of Conjunction Closure, if one has justification for believing each of a set of propositions, one has justification for believing their conjunction. The lottery and preface paradoxes can both be seen as posing challenges for Closure, but leave open familiar strategies for preserving the principle. While this is all relatively well-trodden ground, a new Closure-challenging paradox has recently emerged, in two somewhat different forms, due to Backes (Synthese 196(9):3773–3787, 2019a) and Praolini (Australas J Philos 97(4):715–726, 2019). This paradox synthesises elements of the lottery and the preface and is designed to close off the familiar Closure-preserving strategies. By appealing to a normic theory of justification, I will defend Closure in the face of this new paradox. Along the way I will draw more general conclusions about justification, normalcy and defeat, which bear upon what Backes (Philos Stud 176(11):2877–2895, 2019b) has dubbed the ‘easy defeat’ problem for the normic theory.
Si3N4 nanofelts/paraffin composites as novel thermal energy storage architecture
Authors: Valentini Francesco , Dorigato Andrea , Pegoretti Alessandro , Tomasi Michele , Sorarù Gian D. , Biesuz Mattia 
Published: September 2020

AbstractThe environmental problems associated with global warming are urging the development of novel systems to manage and reduce the energy consumption. An attractive route to improve the energy efficiency of civil buildings is to store the thermal energy thanks, during heating, to the phase transition of a phase-change material (as paraffin) from the solid to the liquid state and vice versa. The stored energy can be then released under cooling. Herein, we developed a novel material (nanofelt) constituted by Si3N4nanobelts able to absorb huge amounts of liquid paraffin in the molten state and to act as an efficient shape stabilizer. The nanofelt manufacturing technology is very simple and easy to be scaled-up. The effect of the Si3N4nanofelts density and microstructure on the paraffin sorption and leakage and on the thermal properties of the resulting composite structures is investigated. It is shown that the produced Si3N4/paraffin composites are able to retain enormous fractions of paraffin (up to 70 wt%) after 44 day of desorption test on absorbent paper towel. The thermal energy storage efficiency measured through calorimetric tests is as high as 77.4% in heating and 80.1% in cooling.
Stable honeycomb structures and temperature based trajectory optimization for wire-arc additive manufacturing
Authors: Bähr Martin , Buhl Johannes , Radow Georg , Schmidt Johannes , Bambach Markus , Breuß Michael , Fügenschuh Armin 
Published: September 2020

AbstractWe consider two mathematical problems that are connected and occur in the layer-wise production process of a workpiece using wire-arc additive manufacturing. As the first task, we consider the automatic construction of a honeycomb structure, given the boundary of a shape of interest. In doing this, we employ Lloyd’s algorithm in two different realizations. For computing the incorporated Voronoi tesselation we consider the use of a Delaunay triangulation or alternatively, the eikonal equation. We compare and modify these approaches with the aim of combining their respective advantages. Then in the second task, to find an optimal tool path guaranteeing minimal production time and high quality of the workpiece, a mixed-integer linear programming problem is derived. The model takes thermal conduction and radiation during the process into account and aims to minimize temperature gradients inside the material. Its solvability for standard mixed-integer solvers is demonstrated on several test-instances. The results are compared with manufactured workpieces.
Baseline chest X-ray in coronavirus disease 19 (COVID-19) patients: association with clinical and laboratory data
Authors: Gatti Marco , Calandri Marco , Barba Matteo , Biondo Andrea , Geninatti Carlotta , Gentile Stephanie , Greco Marta , Morrone Vittorio , Piatti Clara , Santonocito Ambra , Varello Sara , Bergamasco Laura , Cavallo Rossana , Di Stefano Rosario , Riccardini Franco , Boccuzzi Adriana , Limerutti Giorgio , Veltri Andrea , Fonio Paolo , Faletti Riccardo 
Published: September 2020

Abstract
Purpose
To assess the reliability of CXR and to describe CXR findings and clinical and laboratory characteristics associated with positive and negative CXR.

Methods
Retrospective two-center study on consecutive patients admitted to the emergency department of two north-western Italian hospitals in March 2020 with clinical suspicion of COVID-19 confirmed by RT-PCR and who underwent CXR within 24 h of the swab execution. 260 patients (61% male, 62.8 ± 15.8 year) were enrolled. CXRs were rated as positive (CXR+) or negative (CXR−), and features reported included presence and distribution of airspace opacities, pleural effusion and reduction in lung volumes. Clinical and laboratory data were collected. Statistical analysis was performed with nonparametric tests, binary logistic regression (BLR) and ROC curve analysis.

Results
Sensitivity of CXR was 61.1% (95%CI 55–67%) with a typical presence of bilateral (62.3%) airspace opacification, more often with a lower zone (88.7%) and peripheral (43.4%) distribution. At univariate analysis, several factors were found to differ significantly between CXR+ and CXR−. The BLR confirmed as significant predictors only lactate dehydrogenase (LDH), C-reactive protein (CRP) and interval between the onset of symptoms and the execution of CXR. The ROC curve procedure determined that CRX+ was associated with LDH > 500 UI/L (AUC = 0.878), CRP > 30 mg/L (AUC = 0.830) and interval between the onset of symptoms and the execution of CXR > 4 days (AUC = 0.75). The presence of two out of three of the above-mentioned predictors resulted in CXR+ in 92.5% of cases, whereas their absence in 7.4%.

Conclusion
CXR has a low sensitivity. LDH, CRP and interval between the onset of symptoms and the execution of CXR are major predictors for a positive CXR.
Modulation of visual processing of food by transcutaneous vagus nerve stimulation (tVNS)
Authors: Alicart Helena , Heldmann Marcus , Göttlich Martin , Obst Martina A. , Tittgemeyer Marc , Münte Thomas F. 
Published: September 2020

AbstractPresent project is concerned with the possibility to modulate the neural regulation of food intake by non-invasive stimulation of the vagus nerve. This nerve carries viscero-afferent information from the gut and other internal organs and therefore serves an important role in ingestive behavior. The electrical stimulation of the vagus nerve (VNS) is a qualified procedure in the treatment of drug-resistant epilepsy and depression. Since weight loss is a known common side effect of VNS treatment in patients with implanted devices, VNS is evaluated as a treatment of obesity. To investigate potential VNS-related changes in the cognitive processing of food-related items, 21 healthy participants were recorded in a 3-Tesla scanner in two counterbalanced sessions. Participants were presented with 72 food pictures and asked to rate how much they liked that food. Before entering the scanner subjects received a 1-h sham or verum stimulation, which was implemented transcutanously with a Cerbomed NEMOS® device. We found significant activations in core areas of the vagal afferent pathway, including left brainstem, thalamus, temporal pole, amygdala, insula, hippocampus, and supplementary motor area for the interaction between ratings (high vs low) and session (verum vs sham stimulation). Significant activations were also found for the main effect of verum compared to sham stimulation in the left inferior and superior parietal cortex. These results demonstrate an effect of tVNS on food image processing even with a preceding short stimulation period. This is a necessary prerequisite for a therapeutic application of tVNS which has to be evaluated in longer-term studies.
Missed Lisfranc injuries—surgical vs conservative treatment
Authors: Singh Amit , Lokikere Naveen , Saraogi Aakash , Unnikrishnan P. N. , Davenport James 
Published: September 2020

Abstract
Introduction
Lisfranc injuries form a distinct group of rare but severe injury. Literature suggests a low incidence, but failure to diagnose these injuries early and its subsequent delay in management will affect the patient’s mobility and quality of life significantly. The preferred mode of management is said to be surgical. Conversely, the method of intervention for patients not suitable for surgery is less clear.

Aim
This study aims to evaluate the effect of delayed diagnosis and the treatment provided on the overall functional outcome for the patients with missed Lisfranc injury.

Methodology
The study was conducted at a specialist centre in the North-West of UK between January 2011 and November 2016. All patients with acute Lisfranc injuries were included in this study. Patient data was collected through electronic notes and analysed to ascertain missed diagnosis. It was also used to evaluate functional and radiological outcome.

Results
In our series, 58.8% of Lisfranc injuries were missed on their initial presentation. We report better results for the surgical group when compared with the non-operated group, in spite of the delay in diagnosis.

Conclusion
We believe that definitive treatment in the form of surgical fixation and anatomical reduction has more influence on the functional outcome than the timing of the surgical fixation in case of subtle Lisfranc injuries.
Evaluation of exposure dose in fetal computed tomography using organ-effective modulation
Authors: Kobayashi Masanao , Haba Tomonobu , Suzuki Sayaka , Nishihara Yusei , Asada Yasuki , Minami Kazuyuki 
Published: September 2020

AbstractOrgan-effective modulation (OEM) is a computed tomography scanning technique that reduces the exposure dose to organs at risk. Ultrasonography is commonly used for prenatal imaging, but its reliability is reported to be limited. Radiography and computed tomography (CT) are reliable but pose risk of radiation exposure to the pregnant woman and her fetus. Although there are many reports on the exposure dose associated with fetal CT scans, no reports exist on OEM use in fetal CT scans. We measured the basic characteristics of organ-effective modulation (X-ray output modulation angle, maximum X-ray output modulation rate, total X-ray output modulation rate, and noise modulation) and used them in a Monte Carlo simulation to evaluate the effect of this technique on fetal CT scans in terms of image quality and exposure dose to the pregnant woman and fetus. Using ImPACT MC software, Monte Carlo simulations of OEMON and OEMOFF were run on 8 cases involving fetal CT scans. We confirmed that the organ-effective modulation X-ray output modulation angle was 160°; the X-ray output modulation rate increased with increasing tube current; and no modulation occurred at tube currents of 80 mA or below. Our findings suggest that OEM has only a minimal effect in reducing organ exposure in pregnant women; therefore, it should be used on the anterior side (OEMON,front) to reduce the exposure dose to the fetus.
Politics and the Federal Court of Malaysia, 1960–2018: An Empirical Investigation
Authors: Dressel Björn , Inoue Tomoo 
Published: September 2020

AbstractSince its inception in 1957, Malaysia’s Federal Court (FC) has often been embroiled in high-profile decisions that have dramatically shaped the rule of law and constitutional practice in Malaysia. Recent political change has renewed hope that the FC can reassert its early role as an independent and impartial arbiter of political conflict. This paper investigates determinants of the FC’s behaviour since 1960. It draws on a unique data set of 102 major political cases and socio-biographic profiles of the 73 judges who voted in these cases. After describing patterns of court decisions across time and judges, we test specifically for the impact on their decisions of the 1988 judicial crisis, length of time on the bench, the terms of successive prime ministers, and judges’ personal attributes, such as religion and ethnicity. Ethnicity, appointment after 1988, and the appointing prime minister proved to be closely associated with the direction of voting. We then position the results in the context of Malaysia’s evolving constitutional democracy and discuss their implications for students of comparative judicial politics.
The exchange between citizens and elected officials: a social psychological framework for citizen climate activists
Authors: SHERMAN DAVID K. , SHTEYN MICHELLE F. , HAN HAHRIE , VAN BOVEN LEAF 
Published: September 2020

AbstractCitizen activists play a role in translating public concern about the climate crisis to policymakers and elevating it on the political agenda. We consider the dynamic between citizen activists and the decision-makers they seek to influence and we review psychological research relevant to advocating for climate legislation. We conducted a study with citizen activists who lobby the US Congress for a carbon pricing policy to address climate change. The study assessed how activists think about four social psychological approaches: affirmation, social norms, legacy and immediacy. The findings provide a window into activists’ intuitions about which strategies to use, whom to use them with and their perceived effectiveness. A strategy of establishing shared values and common ground (affirmation) was used most frequently overall. A strategy emphasizing the long-term costs and benefits of addressing climate change (legacy) was employed less frequently than affirmation and seen as less effective by activists but it was the only strategy that was associated with perceived increases in Congressional Representatives’ support of the policy. Citizen activists and their interactions with elected officials provide an opportunity for social-behavioral scientists to understand and potentially overcome barriers to enacting climate policy.