bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healing as Constitutive of Jesus’ Mission Handed to the Church
Authors: Wankar Gabriel T. 
Published: May 2020

AbstractAfter a basic statement of the Catholic doctrine on healing ministry, this article adopts the understanding of the World Council of Churches’ document Healing and Wholeness: The Churches’ Role in Health, adopted in 1990 by the central committee. The document views health, healing, and wholeness not just as medical issues, but as embracing the political, social, economic, cultural, and spiritual dimensions. Building on the above, this article proposes an integral approach to sacramental healing for the African Catholic Church, arguing that alongside healing of physical ailments and deliverance from evil and malignant forces, healing must include working for social justice and peace for the people.
Linking Mission and Networks
Authors: Dokman Frans 
Published: May 2020

AbstractThe Ecumenical Water Network (EWN) is a network of churches and Christian organizations promoting people’s access to water around the world. There are many actors on advocacy for water justice; the EWN was formed to make a Christian witness be heard in the present debate on water issues. This article reflects on the meaning of spirituality for the EWN as an organization and on the relationship the EWN has with other actors in the field of water justice. This reflection is intended to ponder the questions which the EWN places at the core of its mission: “why we do, what we do?” Answering these questions contributes to theories and practices on mission and diversity and provides a stimulus to the manner in which organizations for mission and water justice deal with diversity. The perspectives derive from theology, mission studies, management sciences, and social anthropology.
A revised dynamic data envelopment analysis model with budget constraints
Authors: Lim Dong‐Joon , Kim Moon‐Su , Lee Kyu‐Won 
Published: May 2020

AbstractIn this study, we focus on an unintended limitation in the conventional specification of budget constraints in dynamic data envelopment analysis (DEA). In particular, it is revealed that in the existing models, the production possibilities tend to be underestimated owing to misleading assumptions, and consequently, the models yield overstated efficiency measures. Besides addressing the relevant issues, we developed a revised dynamic DEA model to properly take budget constraints into account in a dynamic setting, while preserving the major principles of efficiency analysis. We compared the proposed model with the intertemporal cost indirect technology to clarify the differences. Finally, we illustrated, by way of examples, an empirical case of operational assessment in fire departments.
Methylation‐mediated miR‐214 regulates proliferation and drug sensitivity of renal cell carcinoma cells through targeting LIVIN
Authors: Xu Hao , Wu Shangjun , Shen Xin , Shi Zhan , Wu Ding , Yuan Yuan , Jiang Wei , Wang Qianliang , Ke Qin , Mao Qing , Li Xianlong , Liu Yong , Yuan Pingcheng , Zhang Qinghan , Huang Enying , Chen Xiaogang 
Published: May 2020

AbstractLIVIN, a member of the inhibitor of apoptosis proteins (IAPs), is reported playing important roles in the development and progression of multiple human cancers. However, its underlined mechanisms in human renal cell carcinoma (RCC) are still needed to be clarified. In the present study, we reported that inhibition of miR‐214 promoted the expression of LIVIN, then facilitated RCC cells growth and reduced the sensitivity of RCC cells to chemotherapeutic drugs. In constant, overexpression of miR‐214 had contradictory effects. Further investigation showed that miR‐214 was down‐regulated in RCC because of abnormal methylation. In addition, DNA methyltransferase DNMT1, miR‐214 and LIVIN are directly correlated in RCC patients. In conclusion, these results suggest that abnormal miR‐214 methylation negatively regulates LIVIN, which may promote RCC cells growth and reduced the sensitivity of RCC cells to chemotherapeutic drugs.
Bone tissue engineering using adipose‐derived stem cells and endothelial cells: Effects of the cell ratio
Authors: Mutschall Hilkea , Winkler Sophie , Weisbach Volker , Arkudas Andreas , Horch Raymund E. , Steiner Dominik 
Published: May 2020

AbstractThe microvascular endothelial network is essential for bone formation and regeneration. In this context, endothelial cells not only support vascularization but also influence bone physiology via cell contact‐dependent mechanisms. In order to improve vascularization and osteogenesis in tissue engineering applications, several strategies have been developed. One promising approach is the coapplication of endothelial and adipose derived stem cells (ADSCs). In this study, we aimed at investigating the best ratio of human umbilical vein endothelial cells (HUVECs) and osteogenic differentiated ADSCs with regard to proliferation, apoptosis, osteogenesis and angiogenesis. For this purpose, cocultures of ADSCs and HUVECs with ratios of 25%:75%, 50%:50% and 75%:25% were performed. We were able to prove that cocultivation supports proliferation whereas apoptosis was unidirectional decreased in cocultured HUVECs mediated by a p‐BAD‐dependent mechanism. Moreover, coculturing ADSCs and HUVECs stimulated matrix mineralization and the activity of alkaline phosphatase (ALP). Increased gene expression of the proangiogenic markers eNOS, Flt, Ang2 and MMP3 as well as sprouting phenomena in matrigel assays proved the angiogenic potential of the coculture. In summary, coculturing ADSCs and HUVECs stimulates proliferation, cell survival, osteogenesis and angiogenesis particularly in the 50%:50% coculture.
Associations of sleep with psychological problems and well‐being in adolescence: causality or common genetic predispositions?
Authors: Vermeulen Marije C.M. , van der Heijden Kristiaan B. , Kocevska Desana , Treur Jorien L. , Huppertz Charlotte , van Beijsterveldt Catharina E.M. , Boomsma Dorret I. , Swaab Hanna , Van Someren Eus J.W. , Bartels Meike 
Published: May 2020

BackgroundWhereas short and problematic sleep are associated with psychological problems in adolescence, causality remains to be elucidated. This study therefore utilized the discordant monozygotic cotwin design and cross‐lagged models to investigate how short and problematic sleep affect psychological functioning.MethodsAdolescent twins (N = 12,803, 13–20 years, 42% male) completed questionnaires on sleep and psychological functioning repeatedly over a two‐year interval. Monozygotic twin pairs were classified as concordant or discordant for sleep duration and trouble sleeping. Resulting subgroups were compared regarding internalizing problems, externalizing problems, and subjective well‐being.ResultsCross‐sectional analyses indicated associations of worse psychological functioning with both short sleep and problematic sleep, and cross‐lagged models indicate bidirectional associations. Longitudinal analyses showed that an increase in sleep problems experienced selectively by one individual of an identical twin pair was accompanied by an increase of 52% in internalizing problem scores and 25% in externalizing problem scores. These changes were significantly different from the within‐subject changes in cotwins with unchanged sleep quality (respectively, 3% increase and 5% decrease). Psychological functioning did, however, not worsen with decreasing sleep duration.ConclusionsThe findings suggest that sleep quality, rather than sleep duration, should be the primary target for prevention and intervention, with possible effect on psychological functioning in adolescents.
Metabolic reprogramming and angiogenesis in primary cutaneous Merkel cell carcinoma: expression of hypoxia‐inducible factor‐1α and its central downstream factors
Authors: Toberer F. , Haenssle H.A. , Heinzel‐Gutenbrunner M. , Enk A. , Hartschuh W. , Helmbold P. , Kutzner H. 
Published: May 2020

AbstractBackgroundMetabolic reprogramming and altered gene expression mediated by hypoxia‐inducible factors play crucial roles during tumour growth and progression. Nevertheless, studies analysing the expression of hypoxia‐inducible factor‐1α and its downstream targets in Merkel cell carcinoma (MCC) are lacking but are warranted to shed more light on MCC pathogenesis and to potentially provide new therapeutic options.ObjectivesTo analyse the immunohistochemical expression of hypoxia‐inducible factor‐1α (HIF‐1α), vascular endothelial growth factor‐A (referred to as VEGF throughout the manuscript), VEGF receptor‐2 (VEGFR‐2), VEGF receptor‐3 (VEGFR‐3), glucose transporter‐1 (Glut‐1), monocarboxylate transporter 4 (MCT4) and carbonic anhydrase IX (CAIX) in primary cutaneous MCC.MethodsThe 16 paraffin‐embedded primary cutaneous MCCs (Merkel cell polyomavirus (McPyV) positive/negative: 11/5) were analysed by immunohistochemistry, namely HIF‐1α, VEGF, VEGFR‐2 (KDR), VEGFR‐3 (FLT4), Glut‐1, MCT4 and CAIX. An established quantification score (QS) was applied to quantitate the protein expression by considering the percentage of positive tumour cells (0: 0%; 1: up to 1%; 2: 2–10%; 3: 11–50%; 4: >50%) in relation to the staining intensity (0: negative; 1: low; 2: medium; 3: strong).ResultsHIF‐1α was expressed in all MCCs and predominantly found at the invading edges of tumour margins. The HIF‐1α downstream factors Glut‐1, MCT4 and CAIX were expressed in 13 of 16 MCC (81%), 14 of 16 MCC (88%) and 16 of 16 MCC (100%), respectively. Interestingly, VEGF and VEGFR‐2 were not expressed in tumour cells, whereas VEGFR‐3 was expressed in all MCCs. HIF‐1α was expressed significantly stronger in McPyV+ tumours (QS: 10.36 ± 2.41) than in McPyV− tumours (QS: 5.40 ± 1.34; P = 0.002). Similarly, VEGFR‐3 was also expressed significantly stronger in McPyV+ tumours (QS: 10.00 ± 2.52) than in McPyV− tumours (QS: 5.40 ± 3.43, P = 0.019).ConclusionsOur data provide first evidence for a role of HIF‐1α in induced metabolic reprogramming contributing to MCC pathogenesis. The metabolic signatures of McPyV+ and McPyV− tumours seem to show relevant differences.
Redescription of Rigidohymena inquieta (Stokes, 1887) Berger, 2011 as Metahymena inquieta gen. nov., comb. nov. (Ciliophora, Hypotricha) Based on Morphology, Morphogenesis, and Molecular Phylogeny
Authors: Kabir Ahmed Salahuddin , Bharti Daizy , Kumar Santosh , Shazib Shahed Uddin Ahmed , Shin Mann Kyoon 
Published: May 2020

AbstractThe morphology and morphogenesis of Rigidohymena inquieta (Stokes, 1887) Berger, 2011, isolated from a lawn soil in the campus of the University of Ulsan, Korea, was studied, using live observation and protargol impregnation. The molecular phylogeny was studied based on the SSU rRNA gene sequences. The morphology of the Korean population of R. inquieta matches the previously known populations; however, the morphogenetic pattern shows differences to the species R. candens in the involvement of cirrus V/3 in the anlagen formation. A novel genus namely Metahymena gen. nov. has been erected for the present species based on the ontogenetic difference, and the new combination Metahymena inquieta gen. nov., comb. nov. is proposed. The morphology, morphogenesis, distribution, and phylogeny of M. inquieta are presented. The morphologic and morphogenetic data corroborate the phylogenetic analyses as M. inquieta clusters among the stylonychid ciliates in a clade distant from Rigidohymena candens.
Targeted mutagenesis in Arabidopsis thaliana using CRISPR‐Cas12b/C2c1
Authors: Wu Fan , Qiao Xinyu , Zhao Yafei , Zhang Ziyi , Gao Yifan , Shi Lingfeng , Du Haokun , Wang Lulu , Zhang Ya‐Jie , Zhang Yu , Liu Langyu , Wang Quan , Kong Dejing 
Published: May 2020

AbstractCas12b/C2c1 is a newly identified class 2 CRISPR endonuclease that was recently engineered for targeted genome editing in mammals and rice. To explore the potential applications of the CRISPR‐Cas12b system in the dicot Arabidopsis thaliana, we selected BvCas12b and BhCas12b v4 for analysis. We successfully used both endonucleases to induce mutations, perform multiplex genome editing, and create large deletions at multiple loci. No significant mutations were detected at potential off‐target sites. Analysis of the insertion/deletion frequencies and patterns of mutants generated via targeted gene mutagenesis highlighted the potential utility of CRISPR‐Cas12b systems for genome editing in Arabidopsis.
Deep learning‐based classification of rectal fecal retention and analysis of fecal properties using ultrasound images in older adult patients
Authors: Matsumoto Masaru , Tsutaoka Takuya , Nakagami Gojiro , Tanaka Shiho , Yoshida Mikako , Miura Yuka , Sugama Junko , Okada Shingo , Ohta Hideki , Sanada Hiromi 
Published: May 2020

AbstractAimThe present study aimed to analyze the use of machine learning in ultrasound (US)‐based fecal retention assessment.MethodsThe accuracy of deep learning techniques and conventional US methods for the evaluation of fecal properties was compared. The presence or absence of rectal feces was analyzed in 42 patients. Eleven patients without rectal fecal retention on US images were excluded from the analysis; thus, fecal properties were analyzed in 31 patients. Deep learning was used to classify the transverse US images into three types: absence of feces, hyperechoic area, and strong hyperechoic area in the rectum.ResultsOf the 42 patients, 31 tested positive for the presence of rectal feces, zero were false positive, zero were false negative, and 11 were negative, indicating a sensitivity of 100% and a specificity of 100% for the detection of rectal feces in the rectum. Of the 31 positive patients, 14 had hard stools and 17 had other types. Hard stool was detected by US findings in 100% of the patients (14/14), whereas deep learning‐based classification detected hard stool in 85.7% of the patients (12/14). Other stool types were detected by US findings in 88.2% of the patients (15/17), while deep learning‐based classification also detected other stool types in 88.2% of the patients (15/17).ConclusionsThe results showed that US findings and deep learning‐based classification can detect rectal fecal retention in older adult patients and distinguish between the types of fecal retention.
Protective actions of exercise‐related FNDC5/Irisin in memory and Alzheimer’s disease
Authors: de Freitas Guilherme B. , Lourenco Mychael V. , De Felice Fernanda G. 
Published: May 2020

AbstractThe proportion of elderly populations is rapidly booming, and human lifespan has considerably increased in the past century because of scientific and medical advances. However, the winds of change brought by the 21st century made sedentarism one of the factors that renders the brain vulnerable to age‐related chronic diseases, such as Alzheimer's disease (AD). Conversely, physical exercise has been shown to stimulate molecular mechanisms beneficial to cognition. Here, we review evidence showing the positive effects of physical exercise in the brain. We further discuss recent evidence that irisin, a myokine stimulated by physical exercise derived from fibronectin type III domain‐containing protein 5 (FNDC5) transmembrane protein, has neuroprotective actions in the brain. Lastly, we highlight the importance of the crosstalk between the periphery and the brain in cognition and the therapeutic potential of FNDC5/irisin in AD.
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Screen Time Exposure and Altered Sleep in Young Children With Epilepsy
Authors: Lin Ying‐Ying , Lee Wang‐Tso , Yang Hsiao‐Ling , Weng Wen‐Chin , Lee Chien‐Chang , Jeng Suh‐Fang , Tsai Shao‐Yu 
Published: May 2020

AbstractPurposeTo examine the association between daily screen time exposure and both sleep patterns (sleep onset, sleep offset, and nighttime, and daily sleep durations) and sleep disturbances among a clinical sample of children with epilepsy.DesignA cross‐sectional actigraphic sleep study.MethodsA convenience sample of 141 children with epilepsy (1.5–6 years of age) was recruited from an outpatient pediatric neurology clinic of a university‐affiliated children's hospital in northern Taiwan. Participating families completed questionnaires and reported children's screen time use, with children wearing an actigraphy monitor for 7 days to assess sleep patterns. Multivariable linear regression analyses were conducted to examine the association of screen time exposure with the child's sleep patterns and sleep disturbance scores.FindingsMean minutes per day of screen time exposure was 89.79 ± 83.94 min, with 62 parents (44.0%) reporting their child having >1 hr of screen time daily. Mean daily sleep duration was 9.26 ± 1.01 hr, with 106 children (93.0%) sleeping <10 hr in a 24‐hr period. In multivariate regression models, daily screen time exposure of >1 hour was associated with 23.4‐min later sleep onset (b = 0.39, p = .02), 20.4‐min later sleep offset (b = 0.34, p = .04), and more severe sleep disturbances (b = 2.42, p = .04).ConclusionsIn toddlers and preschool‐age children with epilepsy, daily screen time exposure is greater and sleep duration is shorter than the recommended amount, with increased screen time exposure associated with disturbed sleep.Clinical RelevanceParents need to be informed about the possible adverse impact of screen time exposure on children's sleep and health as well as the importance of limiting screen time exposure to <1 hr per day for their toddlers and preschool‐age children with epilepsy.
The Psychological Toll of Emotion Work in Same‐Sex and Different‐Sex Marital Dyads
Authors: Umberson Debra , Thomeer Mieke Beth , Pollitt Amanda M. , Mernitz Sara E. 
Published: May 2020

AbstractObjectiveThis study considers how the provision of daily emotion work may affect the psychological well‐being of the emotion worker, and how this linkage may vary for men and women in same‐ and different‐sex marriages.BackgroundEmotion work–work intended to bolster a spouse's well‐being by reading and managing the spouse's emotional needs—is common within marital relationships and often gendered, with women more aware of and concerned with emotion work than men. Yet, the psychological cost of performing emotion work is largely unexplored.MethodThis study relies on 10 days of daily experiences data from spouses in same‐ and different‐sex marriages (n = 756 individuals). Mixed effects multilevel regression modeling is used to examine how the provision of emotion work is associated with the emotion workers' psychological well‐being.ResultsProviding emotion work is inversely associated with emotion workers' psychological well‐being, especially when provided for a spouse with elevated depressive symptoms. These estimated effects are generally similar for men and women but greater for those married to a man than for those married to a woman, whether in a same‐ or different‐sex marriage.ConclusionEmotion work appears to adversely affect the worker's own psychological well‐being, especially when a spouse has elevated depressive symptoms and when one's spouse is a man. These results point to the importance of dyadic approaches and consideration of gendered relationship dynamics of same‐ as well as different‐sex couples in studies of emotion work and other marital processes.
Cardiovascular‐renal axis disorder and acute‐phase proteins in cats with congestive heart failure caused by primary cardiomyopathy
Authors: Liu Mengmeng , Köster Liza S. , Fosgate Geoffrey T. , Chadwick Christopher C. , Sanz‐González Íñigo , Eckersall Peter David , Wotton Paul R. , French Anne T. 
Published: May 2020

AbstractBackgroundCurrently, the pathogenesis of congestive heart failure (CHF) in cats is not fully understood.ObjectiveTo identify novel biomarkers for CHF in cats caused by primary cardiomyopathy, particularly related to cardiovascular‐renal axis disorder and systemic inflammatory response.AnimalsTwenty‐five cats in CHF caused by primary cardiomyopathy, 12 cats with preclinical cardiomyopathy, and 20 healthy controls.MethodsCase control and observational case series. The following serum biomarkers were compared among the 3 cat groups: a cardiorenal profile that included N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), symmetric dimethylarginine (SDMA), and creatinine and an inflammatory profile that included 7 acute‐phase proteins (APPs). Survival analyses and longitudinal studies were performed in CHF cats.ResultsAll cardiorenal biomarkers were positively correlated and higher in CHF cats, and high NT‐proBNP and SDMA were associated with poor clinical outcome. Cats with CHF had significantly higher leucine‐rich alpha‐2‐glycoprotein 1, serum amyloid A, and ceruloplasmin, and these APPs were positively correlated with NT‐proBNP and left atrial size. In a multivariable survival analysis, alpha‐1‐acid glycoprotein concentration (P= .01), body weight (P= .02) and left atrial‐to‐aortic root ratio (P= .01) were independent prognostic factors for CHF in these cats.Conclusions and Clinical ImportanceIn cats, CHF is an inflammatory disorder and outcome in CHF may be determined by the extent of inflammation and possibly the amount of residual renal function. These novel biomarkers have potential use for the clinical management, prognosis, and future research into CHF and cardiomyopathy in cats.
Misinformation encountered during a simulated jury deliberation can distort jurors' memory of a trial and bias their verdicts
Authors: Thorley Craig , Beaton Lara , Deguara Phillip , Jerome Brittany , Khan Dua , Schopp Kaela 
Published: May 2020

PurposeJurors swear to base their verdicts solely on the evidence presented at trial. Their recall of a trial during deliberation can, however, be inaccurate, exposing other jurors to misinformation about the trial. This study examined whether jurors who are exposed to misinformation during a simulated deliberation, where the misinformation supports the prosecution's case, will misremember the misinformation as appearing during a trial and be more likely to reach a guilty verdict. It also examined whether allowing jurors to take notes during a trial, and refer to those notes throughout, stops these potentially harmful effects.MethodsOne hundred and twenty‐four participant jurors watched a murder trial. Half were allowed to take notes. They then read a transcript of a deliberation that either contained or did not contain six pieces of pro‐prosecution misinformation. Afterwards, they reached a verdict. Finally, they completed a source monitoring test that required indicating whether the misinformation, and actual trial information, appeared during the trial.ResultsJurors exposed to misinformation misremembered it as appearing during the trial. Those who misattributed the most misinformation to the trial were most likely to reach a guilty verdict. Note taking, and note access, did not stop these effects.ConclusionsJurors can make mistakes when recalling a trial during deliberation but the consequences of this were largely unknown. This study provides initial evidence that their mistakes may distort other jurors' recollection of the trial and bias their verdicts. Attempts to replicate these findings using live deliberations are encouraged to determine their generalizability.
Conflicting‐claims and labour market concerns in a supermultiplier SFC model
Authors: Brochier Lídia 
Published: May 2020

AbstractWe propose to introduce inflation via conflicting‐claims, an endogenous labour productivity regime à la Kaldor‐Verdoorn and an explicit account for the labour market into an SFC model that combines an endogenous autonomous expenditure component with the induced investment behaviour of firms. The aim of the paper is to analyse the dynamics of real wage and productivity growth and the impacts on the long run growth trend, income shares and the employment rate of: (a) changes in the propensity to consume; (b) changes in the bargaining power of workers; and (c) changes in the labour productivity under different institutional settings.