bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operational Impacts of the Coronavirus Disease 2019 (COVID-19) Pandemic and Early Recovery Trends: University of Washington Anatomic Pathology Experience
Authors: Miller Timothy Isaac , Smith Kelly D. , Gonzalez-Cuyar Luis Francisco , Swanson Paul E. 
Published: December 2020

Context.—
The coronavirus disease 2019 pandemic, caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2, has resulted in worldwide disruption to the delivery of patient care. The Seattle, Washington metropolitan area was one of the first in the United States affected by the pandemic. As a result, the anatomic pathology services at the University of Washington experienced significant changes in operational volumes early in the pandemic.

Objective.—
To assess the impact of coronavirus disease 2019 and both state and institutional policies implemented to mitigate viral transmission (including institutional policies on nonurgent procedures) on anatomic pathology volumes.

Design.—
Accessioned specimens from January to June 2020 were evaluated as coronavirus disease 2019 and institutional policies changed. The data were considered in these contexts: subspecialty, billable Current Procedural Terminology codes, and intraoperative consultation. Comparable data were retrieved from 2019 as a historical control.

Results.—
There was a significant reduction in overall accessioned volume (up to 79%) from prepandemic levels during bans on nonurgent procedures when compared with 2020 pre–coronavirus disease 2019 volumes and historical controls. The gastrointestinal and dermatopathology services were most impacted, and breast and combined head and neck/pulmonary services were least impacted. Current Procedural Terminology code 88305, for smaller/biopsy specimens, had a 63% reduction during nonurgent procedure bans. After all bans on procedures were lifted, the overall volume plateaued at 89% of prepandemic levels.

Conclusions.—
A significant decrease in specimen volume was most strongly associated with bans on nonurgent procedures. Although all departmental areas had a decrease in volume, the extent of change varied across subspecialty and specimen types. Even with removal of all bans, service volume did not reach prepandemic levels.
A Healthcare Pilgrim's Progress
Authors: Pitts Peter 
Published: December 2020

Progress is both a noun (forward or onward movement toward a destination) and a verb (to move forward or onward in space or time). Innovation is a noun (the action or process of innovating). They aren’t synonyms. When it comes to the future of healthcare, which is more important? Innovation enables change that maintains an ecosystem. Progress changes the ecosystem. Many new biopharmaceuticals and medical devices are innovative. They can improve both quality of care and quality of life, but do not always represent true progress. Perhaps we need a healthcare technology continuum that considers the value of an innovation (a new molecule, a newly identified receptor, gene therapy, etc.) in the context of progress. Rather than “value-based HTA” we should be thinking about “progress-based HTA. It’s worth repeating that the terms “innovation” and “progress” have separate and distinct meanings. They are, like many generic drugs and biologics, not interchangeable.
Trust, Disconnection, Minimizing risk and Apathy
Authors: Hartley Jannie Møller , Schwartz Sander Andreas 
Published: December 2020

This paper investigates how audiences are coping with digital platforms in their everyday lives. Empirically grounded in focus groups carried out in Denmark with a total of 34 participants of different ages and educational backgrounds, we present the results of an analysis of audiences’ coping tactics in relation to tracking data, collecting data and mining data.
Based on the analysis, we find four overall tactics: coping by absence, coping by trust, coping by minimizing risk and coping by apathy. We argue that these different coping tactics are employed differently depending on the context of the digital routines, the data collected (sensitive vs. non-sensitive data), and the dependence of the platform (private vs. public, national vs. international platforms and apps). These contextual factors are presented in an analytical model—a coping compass—for studying individual users’ coping tactics in their datafied everyday lives.
Planned Behavior in Overcoming Cognitive Dissonance in Ritual Activities of Homecoming (Case Study of Homecoming Travelers Using Motorcycle)
Authors: Latief Abdul , Sihabudin Ahmad , Widowati Dewi 
Published: December 2020

Homecoming in Indonesia has become national traditions. One of transportation for homecoming is a motorcycle. Homecoming by motorcycle has many limitations and raises quite a high risk, as well as an appeal not to go home on a motorcycle from the government, but many still go home on a motorcycle. This study aims to find out what dissonances appear in the travelers who ride motorcycles, and how the travelers' behavioral, normative and control beliefs in dealing with this dissonance.
This research uses qualitative case study methods and data collection techniques through in-depth interviews, with analysis using Theory of Cognitive Dissonance and The Theory of Planned Behavior. Research activities on homecoming are included in the single case category, which researchers carry out on homecoming activities during the Eid al-Fitr homecoming moment in 2019 instead of May-June 2019, with research 18 informants.
The results showed that found cognitive dissonance conditions in the homecoming activities they live. This Dissonance is indicated from the finding that there is denial of one element which is then followed by or following other elements. This research also reveals the effort to eliminate dissonance using 3 (three) elements of The Theory of Planned Behavior, namely Behavioral belief, control belief, and normative belief, which are in line with the methods used by TCD in eliminating dissonance. This research also reveals elements of behavioral belief to overcome cognitive dissonance.
Bioelectronic Implants and Their Role in Modern Medicine
Authors: Nenasheva Ekaterina Vladislavovna , Larina Aleksandra Olegovna , Achmad Harun , Timokhina Tatiana , Markov Alexander 
Published: December 2020

Humanity turned to medicines millions of years ago, when medicinal plants were used for healing. In the century before last, a significant contribution to medicine was made by various fields of science; in particular, here one can name a device that has long been used to deliver medicine to the body – a syringe.
Today, the use of injections of drugs of biological origin is a common practice for the treatment of chronic diseases, but the injection procedure itself is often associated with painful perceptions, and the field of injection is limited. Modern advanced therapies are genetic, electronic and cellular therapies that can meet the needs of caregivers, as well as the patients themselves.
It is well known that digital processes in healthcare are currently undergoing intensive development, and in this context, innovative bioelectronic devices are being used to implement new strategies for personalized injection therapy. This paper examines aspects of the development of innovative methods of drug delivery to the patient's body, such as optogenetic therapy, optogenetic methods, and genetic therapy. For these purposes, bioelectronic implants are used today, in which electronics and optogenetics interact with the help of light, transmitting a certain induction signal to each other. By controlling the synthetic optogenetic pathway in the cell, drugs can be delivered to a particular organ within a clearly limited space or time.
Present technology is revolutionary in medicine, as it can replace a traditional syringe, increasing the accuracy of dosage and time of drug administration, while reducing the involvement of the human factor to a minimum. The technology under consideration also acts as minimally invasive, which minimizes the patient's discomfort when taking medications.
Applications of a Generalized Singular Boundary Value Problem for the Exact Solutions of Some Temperature/Concentration Equations
Authors: Ebaid Abdelhalim , Alharbi Fahad M. 
Published: December 2020

In the field of fluid mechanics, the temperature distribution and the nanoparticles concentration are usually described by singular boundary value problems (SBVPs). Such SBVPs are also used to describe various models with applications in engineering and other areas. Generally, obtaining the analytic solutions of such kind of problems is a challenge due to the singularity involved in the governing equations. In this paper, a class of SBVPs is analyzed. The solution of this class is analyzed and investigated through developing several theorems and lemmas. In addition, the theoretical results are invested to construct several solutions for various models/problems in fluid mechanics in the literature. Moreover, the published results are recovered as special cases of our analysis.
The impact of reappraisal skills on aggressive children
Authors: Maixner‐Schindel Karin , Shechtman Zipora 
Published: December 2020

AbstractThe study investigated the effects of reappraisal training on aggressive children. A pre–post–follow‐up, experimental–control design was used to evaluate the impact of a small‐group intervention that offered practice in reappraisal skills to 89 aggressive children (another 60 were wait‐listed). Results indicate that treatment children benefitted in these skills more than their peers. Based on multiple sources of the report (child, parent, teacher), results also point to reduced aggression, anger, anxiety, and social problems, and an increase in self‐regulation, all of which sustained at follow‐up 7–8 months later. Finally, many outcomes were correlated with benefits in reappraisal skills. Qualitative data gleaned from the study supports these benefits and sheds light on group processes that were helpful. The findings suggest that reappraisal skills training is a useful intervention with aggressive children and can be successfully delivered in small groups.
Confinement Synthesis Based on Layered Double Hydroxides: A New Strategy to Construct Single‐Atom‐Containing Integrated Electrodes
Authors: Fan Kui , Li Zhenhua , Song Yingjie , Xie Wenfu , Shao Mingfei , Wei Min 
Published: December 2020

AbstractHighly efficient and low‐cost electrodes have a key role in the development of advanced energy devices such as fuel cells and metal–air batteries. However, electrode performance is typically limited by low utilization of active sites, which causes a considerable drop in energy density. To overcome this issue, a single‐atom‐containing integrated electrode is developed through a confinement synthesis strategy by using organic molecule‐intercalated layered double hydroxides (LDHs) as precursors. The as‐prepared integrated electrode has a well‐defined nanosheet array structure with a homogeneous anchored single atomic Co catalyst and many exposed hierarchical pores. Moreover, the coordination environment of single atoms (CoN or CoS) is precisely controlled by regulating the type of interlayer molecules in the LDHs. Consequently, the optimized electrode exhibits high bifunctional activity toward both the oxygen reduction and oxygen evolution reactions. This electrode is directly assembled into an all‐solid‐state zinc–air battery that showed outstanding flexibility and long‐term charge/discharge stability. Because of the versatility of LDH materials, it is expected that the proposed strategy can be extended to the construction of other integrated electrodes for high‐performance energy storage and conversion devices.
Textile Technology for Soft Robotic and Autonomous Garments
Authors: Sanchez Vanessa , Walsh Conor J. , Wood Robert J. 
Published: December 2020

AbstractTextiles have emerged as a promising class of materials for developing wearable robots that move and feel like everyday clothing. Textiles represent a favorable material platform for wearable robots due to their flexibility, low weight, breathability, and soft hand‐feel. Textiles also offer a unique level of programmability because of their inherent hierarchical nature, enabling researchers to modify and tune properties at several interdependent material scales. With these advantages and capabilities in mind, roboticists have begun to use textiles, not simply as substrates, but as functional components that program actuation and sensing. In parallel, materials scientists are developing new materials that respond to thermal, electrical, and hygroscopic stimuli by leveraging textile structures for function. Although textiles are one of humankind's oldest technologies, materials scientists and roboticists are just beginning to tap into their potential. This review provides a textile‐centric survey of the current state of the art in wearable robotic garments and highlights metrics that will guide materials development. Recent advances in textile materials for robotic components (i.e., as sensors, actuators, and integration components) are described with a focus on how these materials and technologies set the stage for wearable robots programmed at the material level.
Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy
Authors: Zeng Ziling , Zhang Chi , Li Jingchao , Cui Dong , Jiang Yuyan , Pu Kanyi 
Published: December 2020

AbstractTumor immunometabolism contributes substantially to tumor proliferation and immune cell activity, and thus plays a crucial role in the efficacy of cancer immunotherapy. Modulation of immunometabolism to boost cancer immunotherapy is mostly based on small‐molecule inhibitors, which often encounter the issues of off‐target adverse effects, drug resistance, and unsustainable response. In contrast, enzymatic therapeutics can potentially bypass these limitations but has been less exploited. Herein, an organic polymer nanoenzyme (SPNK) with near‐infrared (NIR) photoactivatable immunotherapeutic effects is reported for photodynamic immunometabolic therapy. SPNK is composed of a semiconducting polymer core conjugated with kynureninase (KYNase) via PEGylated singlet oxygen (1O2) cleavable linker. Upon NIR photoirradiation, SPNK generates 1O2 not only to exert photodynamic effect to induce the immunogenic cell death of cancer, but also to unleash KYNase and trigger its activity to degrade the immunosuppressive kynurenine (Kyn). Such a combinational effect mediated by SPNK promotes the proliferation and infiltration of effector T cells, enhances systemic antitumor T cell immunity, and ultimately permits inhibition of both primary and distant tumors in living mice. Therefore, this study provides a promising photodynamic approach toward remotely controlled enzymatic immunomodulation for improved anticancer therapy.
Coco Stretch: Strain Sensors Based on Natural Coconut Oil and Carbon Black Filled Elastomers
Authors: Lugoda Pasindu , Costa Júlio C. , Garcia‐Garcia Leonardo A. , Pouryazdan Arash , Jocys Zygimantas , Spina Filippo , Salvage Jonathan , Roggen Daniel , Münzenrieder Niko 
Published: December 2020

AbstractA biocompatible inexpensive strain sensor constituting of an elastomer filled with natural coconut oil (CNO) and carbon black (CB) is presented here. Strain sensors are widely utilized for applications in human activity recognition, health monitoring, and soft robotics. Given that these sensors are envisioned to be present in a plethora of fields, it is important that they are low cost, reliable, biocompatible, and eco‐friendly. This work demonstrates that CNO can be used to create conductive percolation network in elastomers, without the necessity for harmful chemicals or expensive machinery. The sensor has a gauge factor of 0.77 ± 0.01, and the sensing material has a porous morphology filled with an oily suspension formed of CNO and CB. Results indicate that the liquid filled porous structure can improve the reliability of these resistive strain sensors in comparison to sensors fabricated utilizing commonly used non‐polar solvents such as heptane. Consequently, the sensor demonstrates a hysteresis of only 2.41% at 200% strain over 250 stretch/release cycles. Finally, to demonstrate the potential of this fabrication technique, a functionalized glove is developed and used to detect wrist motion. These easily manufacturable and cost‐effective sensors enable wearable on‐skin ergonomic intervention systems with minimal impact on the environment.
Kinetic Resolution and Dynamic Kinetic Resolution of γ‐Aryl‐Substituted Butenolides via Copper‐Catalyzed 1,4‐Hydroboration
Authors: Lee Soyeon , Ryu Do Hyun , Yun Jaesook 
Published: December 2020

AbstractKinetic resolution (KR) and dynamic kinetic resolution (DKR) of γ‐aryl and heteroaryl‐substituted butenolides via CuH‐catalyzed 1,4‐hydroboration using pinacolborane is reported. With a copper‐Ph‐BPE catalyst, selectivity factors were extremely high (s=>400) with regard to the kinetic resolution of β‐methyl‐γ‐phenyl butenolide; DKR was possible in the presence of an amine base (DBU), which facilitated racemization of the starting unsaturated lactones. The reaction provided easy access to highly enantioenriched γ‐butyrolactones (>99% ee) containing β,γ‐substituents.magnified image
Which is better to use “body weight” or “standard liver weight”, for predicting small‐for‐size graft syndrome after living donor liver transplantation?
Authors: Toshima Takeo , Yoshizumi Tomoharu , Shimagaki Tomonari , Wang Huanlin , Kurihara Takeshi , Nagao Yoshihiro , Itoh Shinji , Harada Noboru , Mori Masaki 
Published: December 2020

AbstractAimLittle evidence about whether to apply graft‐to‐recipient body weight ratio (GRWR) or graft weight to standard liver weight (GW/SLW) for graft selection has been published. The aim of the present study was to clarify the importance of the correct use of GRWR and GW/SLW for selecting graft according to the recipients’ physique in living donor liver transplantation (LDLT).MethodsData were collected for 694 recipients who underwent LDLT between 1997 and 2020.ResultsOne of the marginal grafts meeting GW/SLW ≥ 35% but GRWR < 0.7% has been used in more recipients with men and higher body mass index (BMI), and the other meeting GRWR ≥ 0.7% but GW/SLW < 35% has been used in more recipients with women with lower BMI. In the cohort of BMI > 30 kg/m2, the recipients with GRWR < 0.7% had a significantly higher incidence of small‐for‐size graft syndrome (SFSS) compared to those with GRWR ≥ 0.7% (P = 0.008, 46.2% vs 5.9%), and using the cutoff of GW/SLW < 35% could not differentiate. In contrast, in the cohort of BMI ≤ 30 kg/m2, the recipients with GW/SLW < 35% also had a significantly higher incidence of SFSS (P = 0.013, 16.9% vs 9.4%). Multivariate analysis showed that GRWR < 0.7% [odds ratio (OR) 14.145, P = 0.048] was the independent risk factor for SFSS in obese recipients, and GW/SLW < 35% [OR 2.685, P = 0.002] was the independent risk factor in non‐obese recipients.ConclusionProper use of the formulas for calculating GRWR and GW/SLW in choosing graft according to recipient BMI is important, not only to meet metabolic demand for avoiding SFSS but also to ameliorate donor shortages.
First‐line treatment of double‐hit and triple‐hit lymphomas: Survival and tolerance data from a retrospective multicenter French study
Authors: Laude Marie‐Charlotte , Lebras Laure , Sesques Pierre , Ghesquieres Herve , Favre Simon , Bouabdallah Krimo , Croizier Carolyne , Guieze Romain , Drieu La Rochelle Laurianne , Gyan Emmanuel , Chin Roza , Aurran‐Schleinitz Thérèse , Marouf Amira , Deau‐Fischer Bénédicte , Coppo Paul , Malot Sandrine , Roussel Xavier , Chauchet Adrien , Schwarz Marianne , Bescond Charles , Lamy de la Chapelle Thierry , Bussot Lucile , Carras Sylvain , Burlet Bénédicte , Rossi Cédric , Daniel Adrien , Morschhauser Franck , Subtil Fabien , Michallet Anne‐Sophie 
Published: December 2020

AbstractHistorically, double or triple hit lymphoma (DHL and THL) have poor outcomes with conventional chemotherapy, but there is currently no guideline. We report the French experience in managing DHL and THL in first line using collective data on both survival and tolerance. All consecutive patients with newly diagnosis of large B‐cell lymphoma with MYC, BCL2, and/or BCL6 rearrangements, as determined by FISH between January 2013 and April 2019 were included. Based on the eligibility criteria, 160 patients were selected among the 184 patients identified. With a median follow‐up of 32 months, 2‐ and 4‐year progression free survival (PFS) rates were 40% and 28% with R‐CHOP compared with 57% and 52% with intensive chemotherapy (P = .063). There was no difference in overall survival (OS). For advanced stages, PFS was significantly longer with intensive chemotherapy than with R‐CHOP (P = .029). There was no impact of autologous stem cell transplantation among patient in remission. For patients with central nervous system (CNS) involvement, the 2‐year PFS and OS rate was 21% and 39%, vs 57% and 75% without CNS disease (P = .007 and P < .001). By multivariate analysis, elevated IPI score and CNS disease were strongly and independently associated with a poorer survival, whereas treatment was not significantly associated with OS. This is the largest series reporting the treatment of DHL and THL in Europe. The PFS was significantly longer with an intensive regimen for advanced stage, but no difference in OS, supporting the need for a prospective randomized trial.
CDKN2A deletions are associated with poor outcomes in 101 adults with T‐cell acute lymphoblastic leukemia
Authors: Wang Huan‐Ping , Zhou Yi‐Le , Huang Xin , Zhang Yi , Qian Jie‐Jing , Li Jian‐Hu , Li Xue‐Ying , Li Chen‐Ying , Lou Yin‐Jun , Mai Wen‐Yuan , Meng Hai‐Tao , Yu Wen‐Juan , Tong Hong‐Yan , Jin Jie , Zhu Hong‐Hu 
Published: December 2020

AbstractThe identification of genetic risk subgroups of T‐cell acute lymphoblastic leukemia (T‐ALL) may provide evidence for risk stratification and individualized treatment. We investigated the characteristics and prognostic value of tumor suppressor gene CDKN2A deletions in 101 patients with T‐ALL. The CDKN2A deletion was present in 23% (23/101) of T‐ALL by fluorescence in situ hybridization (FISH). The most common type of CDKN2A deletion was homozygous deletion (70%, 16/23). A lower frequency of CDKN2A deletion was found in patients with early T‐cell precursor (ETP) ALL than in patients with non‐ETP‐ALL (10.4% vs 34.0%; P = .008). Deletion of CDKN2A was significantly associated with younger age (P = .001), higher white blood cell (WBC) count (P < .001) and higher lactate dehydrogenase (LDH) level (P = .002). Patients with CDKN2A deletion had lower 2‐year overall survival (OS) and event‐free survival (EFS) rates than patients without CDKN2A deletion (2‐year OS: 18.6% ± 8.9% vs 47.4% ± 6.2%, P = .032; EFS: 16.4 ± 8.3 vs 38.6 ± 5.9%, P = .022). In multivariable analysis, CDKN2A deletion was an independent adverse prognostic factor for OS (P = .016). In conclusion, adult T‐ALL patients with CDKN2A deletion had a poor prognosis, and these patients might benefit from intensive chemotherapy or allogeneic hematopoietic stem‐cell transplantation.