bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weighted gene co-expression network analysis revealed key biomarkers associated with the diagnosis of hypertrophic cardiomyopathy
Authors: Li Xin , Wang Chenxin , Zhang Xiaoqing , Liu Jiali , Wang Yu , Li Chunpu , Guo Dongmei 
Published: October 2020

Abstract
Objective
To reveal the molecular mechanism underlying the pathogenesis of HCM and find new effective therapeutic strategies using a systematic biological approach.

Methods
The WGCNA algorithm was applied to building the co-expression network of HCM samples. A sample cluster analysis was performed using the hclust tool and a co-expression module was constructed. The WGCNA algorithm was used to study the interactive connection between co-expression modules and draw a heat map to show the strength of interactions between modules. The genetic information of the respective modules was mapped to the associated GO terms and KEGG pathways, and the Hub Genes with the highest connectivity in each module were identified. The Wilcoxon test was used to verify the expression level of hub genes between HCM and normal samples, and the “pROC” R package was used to verify the possibility of hub genes as biomarkers. Finally, the potential functions of hub genes were analyzed by GSEA software.

Results
Seven co-expression modules were constructed using sample clustering analysis. GO and KEGG enrichment analysis judged that the turquoise module is an important module. The hub genes of each module are RPL35A for module Black, FH for module Blue, PREI3 for module Brown, CREB1 for module Green, LOC641848 for module Pink, MYH7 for module Turquoise and MYL6 for module Yellow. The results of the differential expression analysis indicate that MYH7 and FH are considered true hub genes. In addition, the ROC curves revealed their high diagnostic value as biomarkers for HCM. Finally, in the results of the GSEA analysis, MYH7 and FH highly expressed genes were enriched with the “proteasome” and a “PPAR signaling pathway,” respectively.

Conclusions
The MYH7 and FH genes may be the true hub genes of HCM. Their respective enriched pathways, namely the “proteasome” and the “PPAR signaling pathway,” may play an important role in the development of HCM.
E-cigarette, or vaping, product use-associated lung injury: a review
Authors: Belok Samuel H. , Parikh Raj , Bernardo John , Kathuria Hasmeena 
Published: October 2020

Abstract
Background
E-cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI) is a disease entity related to the use of battery-operated or superheating devices that create an aerosolized form of nicotine and tetrahydrocannabinol (THC) and/or other substances for inhalation.

Methods
We performed a literature review to document epidemiology, pathogenesis and risk factors, diagnosis, clinical presentation, evaluation and management of EVALI.

Results
In the summer of 2019, an outbreak of EVALI cases brought this disease entity into the national spotlight. Since being recognized as a serious pulmonary disease with public health implications, more than 2600 cases have been reported to CDC with 68 deaths as of February 2020. The pathophysiology of EVALI remains unknown. Substances such as Vitamin E acetate have been implicated as a possible causes of lung injury. The CDC has established case definitions of “confirmed EVALI” cases to help guide identification of the disease and assist in surveillance. While clinical judgement by healthcare providers is imperative in the identification of EVALI cases, the heterogeneous presentations of EVALI make this difficult as well. Ultimately most investigative studies should be aimed at ruling out other disease processes that can present similarly. Treatment is centered around removing the offending substance and providing supportive care.

Conclusions
EVALI is a serious pulmonary disease with public health implications. Diagnosis requires a high degree of suspicion to diagnose and exclusion of other possible causes of lung disease. It may be beneficial to involve a pulmonary specialist early in the management of this disease which is generally supportive care.
Phenylpropanoid metabolism and pigmentation show divergent patterns between brown color and green color cottons as revealed by metabolic and gene expression analyses
Authors: LI Zhonghua , SU Qian , XU Mingqi , YOU Jiaqi , KHAN Anam Qadir , LI Junyi , ZHANG Xianlong , TU Lili , YOU Chunyuan 
Published: October 2020

AbstractBackgroundNaturally-colored cotton has become increasingly popular because of their natural properties of coloration, UV protection, flame retardant, antibacterial activity and mildew resistance. But poor fiber quality and limited color choices are two key issues that have restricted the cultivation of naturally-colored cotton. To identify the possible pathways participating in fiber pigmentation in naturally-colored cottons, five colored cotton accessions in three different color types (with green, brown and white fiber) were chosen for a comprehensive analysis of phenylpropanoid metabolism during fiber development.ResultsThe expression levels of flavonoid biosynthesis pathway genes in brown cotton fibers were significantly higher than those in white and green cotton fibers. Total flavonoids and proanthocyanidin were higher in brown cotton fibers relative to those in white and green cotton fibers, which suggested that the flavonoid biosynthesis pathway might not participate in the pigmentation of green cotton fibers. Further expression analysis indicated that the genes encoding enzymes for the synthesis of caffeic acid derivatives, lignin and lignan were activated in the developing fibers of the green cotton at 10 and 15 days post-anthesis.ConclusionsOur results strengthen the understanding of phenylpropanoid metabolism and pigmentation in green and brown cotton fibers, and may improve the breeding of naturally-colored cottons.
Molecular Analysis of the CYP11B2 Gene in 62 Patients with Hypoaldosteronism Due to Aldosterone Synthase Deficiency
Authors: Merakou Christina , Fylaktou Irene , Sertedaki Amalia , Dracopoulou Maria , Voutetakis Antonis , Efthymiadou Alexandra , Christoforidis Athanasios , Dacou-Voutetakis Catherine , Chrysis Dionisios , Kanaka-Gantenbein Christina 
Published: October 2020

Abstract

Context
Isolated congenital hypoaldosteronism presents in early infancy with symptoms including vomiting, severe dehydration, salt wasting, and failure to thrive. The main causes of this rare autosomal recessive disorder is pathogenic variants of the CYP11B2 gene leading to aldosterone synthase deficiency.

Objective
To investigate the presence of CYP11B2 pathogenic variants in a cohort of patients with a clinical, biochemical, and hormonal profile suggestive of aldosterone synthase deficiency.

Design
Clinical and molecular study.

Setting
Tertiary academic Children’s Hospital, Center for Rare Pediatric Endocrine Diseases.

Patients and Methods
Sixty-two patients (56 unrelated patients and 6 siblings), with hypoaldosteronism and their parents, underwent CYP11B2 gene sequencing after its selective amplification against the highly homologous CYP11B1 gene. In silico analysis of the identified novel variants was carried out to evaluate protein stability and potential pathogenicity.

Results
CYP11B2 gene sequencing revealed that 62 patients carried a total of 12 different pathogenic CYP11B2 gene variants, 6 of which are novel. Importantly, 96% of the 56 patients carried the previously reported p.T185I variant either in homozygosity or in compound heterozygosity with another variant. The 6 novel variants detected were: p.M1I, p.V129M, p.R141Q, p.A165T, p.R448C, and the donor splice site variant of intron 8, c.1398 + 1G &gt; A.

Conclusion
Molecular diagnosis was achieved in 62 patients with aldosterone synthase deficiency, the largest cohort thus far reported. Six novel genetic variants were identified as possibly pathogenic, extending the spectrum of reported molecular defects of the CYP11B2 gene.
Effect of Exercise Intensity on Exogenous Glucose Requirements to Maintain Stable Glycemia At High Insulin Levels in Type 1 Diabetes
Authors: Shetty Vinutha B , Fournier Paul A , Paramalingam Nirubasini , Soon Wayne , Roby Heather C , Jones Timothy W , Davis Elizabeth A 
Published: October 2020

Abstract

Context
Under basal insulin levels, there is an inverted U relationship between exercise intensity and exogenous glucose requirements to maintain stable blood glucose levels in type 1 diabetes (T1D), with no glucose required for intense exercise (80% V̇O2 peak), implying that high-intensity exercise is not conducive to hypoglycemia.

Objective
This work aimed to test the hypothesis that a similar inverted U relationship exists under hyperinsulinemic conditions, with high-intensity aerobic exercise not being conducive to hypoglycemia.

Methods
Nine young adults with T1D (mean ± SD age, 22.6 ± 4.7 years; glycated hemoglobin, 61 ± 14 mmol/mol; body mass index, 24.0 ± 3.3 kg/m2, V̇O2 peak, 36.6 ± 8.0 mL·kg–1 min–1) underwent a hyperinsulinemic-euglycemic clamp to maintain stable glycemia (5-6 mmol·L−1), and exercised for 40 minutes at 4 intensities (35%, 50%, 65%, and 80% V̇O2peak) on separate days following a randomized counterbalanced study design.

Main Outcome Measures
Glucose infusion rates (GIR) and glucoregulatory hormones levels were measured.

Results
The GIR (± SEM) to maintain euglycemia was 4.4 ± 0.4 mg·kg–1 min–1 prior to exercise, and increased significantly by 1.8 ± 0.4, 3.0 ± 0.4, 4.2 ± 0.7, and 3.5 ± 0.7 mg·kg–1 min–1 during exercise at 35%, 50%, 65%, and 80% V̇O2 peak, respectively, with no significant differences between the 2 highest exercise intensities (P &gt; .05), despite differences in catecholamine levels (P &lt; .05). During the 2-hour period after exercise at 65% and 80% V̇O2 peak, GIRs did not differ from those during exercise (P &gt; .05).

Conclusions
Under hyperinsulinemic conditions, the exogenous glucose requirements to maintain stable glycemia during and after exercise increase with exercise intensity then plateau with exercise performed at above moderate intensity ( &gt; 65% V̇O2 peak). High-intensity exercise confers no protection against hypoglycemia.
Professionalismi, õppimise ja identiteedi kontseptsioonide sidumine
Authors: Ruijters Manon C. P. , Simons P. Robert-Jan 
Published: October 2020

Selles kontseptuaalses artiklis püüame ühendada mõned oma varasematest käsitustest uueks sidusaks õppija identiteedi mudeliks. Artikli esimeses osas esitame ülevaate teadusuuringutest ja teooriatest, mis käsitlevad professionaalset ja töökohal õppimist. Teises osas vaatleme töötamist nn õppe maastikul. See on metafoor, mida kasutame organisatsioonilise õppimise kirjeldamiseks. Kolmandas osas käsitleme õppimiseelistusi: kirjeldame viit töökohal õppimise viisi. Neljandas osas tutvustame õppiva professionaali kontseptsiooni. Viiendas osas anname ülevaate teadusuuringutest ja teooriatest, mis käsitlevad professionaalset identiteeti, mille lahutamatuteks osadeks on see, kes sa oled (inimesena), millist tööd (elukutse) ja kus sa seda teed (keskkond). Arutelu osas püüame selgitada, kuidas saab erinevaid mudeleid ühendada, diferentseerida ja lõimida. Kõikide käsitluste puhul lähtume professionaalsest identiteedist. Lõimitud kontseptuaalses küsimustikus võtame kogu teema kokku, pakume välja õppija identiteedi uue kontseptsiooni ja näitame, milliseid tulemusi annab professionaalse õppimiskultuuri soodustamine.
Full text
Eesti keele ja matemaatika õppevara valiku põhimõtted ja eesmärgid lasteaia- ja klassiõpetajate hinnangul
Authors: Taimalu Merle , Uibu Krista , Leola Heily 
Published: October 2020

Kvaliteetne õppevara on abivahend, mis on õpetajale toeks laste arengu eesmärgipärasel suunamisel. Uurimuse eesmärk oli välja selgitada, millisena hindavad Eesti lasteaia- ja klassiõpetajad oma võimalusi otsustada eesti keele ja matemaatika õppevara valiku üle, millistest põhimõtetest nad lähtuvad ja milliste eesmärkide täitmist õppevara puhul oluliseks peavad. Erinevuste väljaselgitamiseks lasteaia- ja klassiõpetajate hinnangute vahel küsitleti 64 lasteaiaõpetajat ja 47 klassiõpetajat, kasutades valikvastuste ja avatud küsimustega ankeeti. Õppevara valiku põhimõtteid analüüsides eristus neli peakategooriat: vastavus õppekavale, sisu ja ülesannete mitmekesisus, sisu ja ülesannete selgus ja arusaadavus, välised tegurid. Õppevara eesmärkidest tõid õpetajad kõige sagedamini välja, et heal tasemel õppevara peaks toetama laste kognitiivsete oskuste kujundamist. Samuti selgus, et võrreldes klassiõpetajatega saavad lasteaiaõpetajad rohkem ise otsustada, millist õppevara eesti keele või matemaatika õpetamisel kasutada. Teadvustades, millistest põhimõtetest õppevara valikul lähtuda ja milliseid eesmärke heal tasemel õppevara täidab, saab õpetaja teha otsuseid, mis toetavad mitmekülgselt lapse arengut.
Summary
Otsides "müstilist miskit": millest koosneb kooli maine?
Authors: Tikerperi Mari-Liis 
Published: October 2020

Kooli maine on leidnud Eesti üldhariduse kontekstis käsitlemist kui koondmõiste, mis määrab kooli positsiooni abstraktses võrdluses teistega. Teoreetilised lähenemised näevad maine seoseid organisatsiooni identiteediga ja mainekujundust osana organisatsiooni juhtimisest. Muutunud ühiskondlikud nõudmised ja nüüdisaja meediaruum on koolijuhtimisse toonud muu hulgas vajaduse olla nähtav ning kujundada oma tegevust huvirühmade ootuste järgi. Kvalitatiivse uuringu eesmärk oli välja selgitada, millised indikaatorid loovad koolijuhtide (N = 19) hinnangul arusaama kooli mainest ning millised on koolide kogemused mainekujundusega. Olulise tulemusena võib näha, et kooli maine ei ole konstantne väärtus, vaid sõltub üldiselt pikemast ajalisest faktorist ja maine tajuja positsioonist huvirühmade koosseisus. Maine teadlikumaks kujundamiseks pole aga alati piisavalt vahendeid ega oskusi ning osa mainekujunduslikest katsumustest on seotud hoopis kooliväliste teguritega.
Summary
Väärtuskasvatust toetavad tegevused ja nende enesehinnanguline tulemuslikkus Eesti üldhariduskoolide näitel
Authors: Parder Mari-Liisa , Hirsnik Helen 
Published: October 2020

Siinse uurimuse eesmärk on analüüsida väärtuskasvatust toetavaid tegevusi ja nende tulemuslikkuse hindamist Eesti üldhariduskoolides. Uurime, kuivõrd toovad Eesti üldhariduskoolid refleksiooni kaudu välja väärtusi toetavaid tegevusi ning analüüsivad deklareeritud ja tegevustes rakendatavate väärtuste kooskõla. Vaatluse all on tegevused, mida koolid seostavad väärtuskasvatuse toetamisega, ning see, kas ja milliste meetoditega analüüsivad koolid väärtuskasvatust toetavate tegevuste tulemuslikkust. Analüüsi aluseks on üldhariduskoolide koostatud eneseanalüüsid, mis on esitatud Tartu Ülikooli eetikakeskuse tunnustusprogrammi ja mis sisaldavad väärtusarenduse analüüsi neljas valdkonnas. Valimisse kuulub 39 eneseanalüüsi aastatest 2010; 2016 ja 2019, mida analüüsiti kvalitatiivse sisuanalüüsi abil. Siinse uurimuse põhjal saab öelda, et Eesti koolides on levinud integreeriv eetiline kasvatus.
Summary
A Scholar Poet from the Neighbouring Land
Authors: Chettiarthodi Rajendran 
Published: October 2020

A Scholar Poet from the Neighbouring Land: Uddaṇḍa Śāstrin’s Perceptions of Kerala
The present paper proposes to investigate the perceptions of Kerala in the works of Uddaṇḍa Śāstrin, a remarkable scholar, who came in search of patronage to the court of Mānavikrama, the Zamorin of Calicut of the 15th century A.D, from Lāṭapura, a famous Brahmin centre in Toṇḍamaṇḍala, in Chengalpattu, in the present Tamil Nadu. Often stereotyped as a haughty outsider looking down upon his contemporaries with contempt, Uddaṇḍa was actually a sharp-witted scholar, who readily appreciated the scholarship of his adopted land, even while mincing no words when he encountered mediocrity. His message poem Kokilasandeśa and his play Mallikāmāruta, as well as many stray verses still current in Kerala, apart from being a veritable treasure of information as far as medieval Kerala is concerned, are of great cultural significance as they register the perceptions of a gifted scholar poet from the neighbouring land. Unfortunately, in popular imagination, he is projected as a haughty outsider outsmarting indigenous scholarship, but ultimately defeated by a native prodigy in the form of Kākkaśśeri Bhaṭṭatiri. This paper aims at retrieving Uddaṇḍa’s valuable and often unbiased insights of Kerala, which are often overlooked in popular perceptions of him. As a sensitive author who recorded his impressions on crossing the geographical boundaries of his native land to reach Kerala, his firsthand accounts of great cities, centres of learning, famous temples, food habits and festivals, such as Ōṇaṃ of Kerala, that can be found in his works are really worth probing.
The Female Voice and the Crossing of the Boundaries of Scholarship
Authors: Anandakichenin Suganya 
Published: October 2020

The Female Voice and the Crossing of the Boundaries of Scholarship: A Note on the Rahasyam of the Lady from Tirukkōḷūr, with a Complete, Annotated Translation
The Śrīvaiṣṇavas are prolific writers, who masterfully used multiple languages for composing works in a range of genres, from commentaries to esoterical works, from devotional poetry to hagiography. But while this community, roughly half of which consists of women, claims equality with a difference for women—which includes the right to liberation at death and to religious, albeit non-Vedic, learning—it hardly seems to have encouraged them to emulate the male authors and produce works of any kind. Despite this attitude, a few female voices, sometimes muffled as they can be, are heard across the centuries. One such voice belongs to Tirukkōḷūr peṇpiḷḷai (“the woman from Tirukkōḷūr,” 12th c.?), who allegedly spoke words betraying her scholarly knowledge, and that, too, to the great Rāmānuja himself. Who this woman—who ventured into the jealously-guarded male domain of scholarship—was, and what her ‘composition’ deals with are the topics of this brief essay.
Exit God: Border Crossings in Jīrṇoddhāra Procedure
Authors: Mills Libbie 
Published: October 2020

Exit God: Border Crossings in Jīrṇoddhāra Procedure
Jīrṇoddhāra, the disposal and replacement of an old idol or temple, necessitates the temporary departure of the deity from that place. The ritual for this departure will be followed as it is reported in two texts: the Piṅgalāmata and the Tantrasamuccaya. The Piṅgalāmata is useful in understanding the process of jīrṇoddhāra: the text defines the process, explains the need for it, rationalises the ritual procedure, and gives a brief account of it. The description in the Tantrasamuccaya gives finer detail on how the procedure should be carried out. Unlike other records of the subject, that of the Tantrasamuccaya does not glide over the most important moments of transition for the deity, but stops to consider them in depth, giving attention to his displacement in terms of saṅkocana (contraction), niṣkrāmaṇa (expulsion), and sūtracchidā (the severing of the cord). While this pair of texts offers the material in contrasting forms, the two sets of teaching are found to be congruent one with the other, making them companion pieces that give us a good view into what it means to invite the deity to leave. We find that in order for the deity to cross concentric borders to leave his base, the human ritual officiant must make a crossing too, and, indeed, the borders themselves will be moved around.
Perancangan Aplikasi Ujian Online Jurusan Sistem Komputer Universitas Diponegoro
Authors: Meinawati Tristy , Satoto Kodrat Iman , Nurhayati Oky Dwi 
Published: October 2020

E-service adalah istilah untuk suatu layanan elektronik yang memanfaatkan teknologi informasi dan komunikasi untuk mempermudah penggunanya untuk melakukan suatu aktifitas tertentu. Salah satu manfaat dari e-service adalah akses yang lebih luas. Salah satu aplikasi dari e-service adalah aplikasi ujian online. Aplikasi ujian online adalah aplikasi yang bertujuan mempermudah melakukan ujian, yaitu secara online. Aplikasi ujian online difokuskan untuk ujian penerimaan mahasiswa baru pada Jurusan Sistem Komputer karena Jurusan Sistem Komputer tersebut berkaitan erat dengan teknologi informasi sehingga sewajarnya jika penerimaan mahasiswa baru dilaksanakan secara online.Dengan menggunakan sebuah sistem basis data, ujian online ini diharapkan mempermudah sistem ujian dalam menampilkan soal-soal maupun penilaian sehingga mempermudah user untuk menggunakannya serta bagi administrator untuk mengelola soal. Dalam e-service yang dibuat kali ini adalah menggunakan PHP sebagai program aplikasi dan MySQL sebagai server basis data yang sudah terangkum dalam satu aplikasi XAMPP.Dengan adanya aplikasi ini diharapkan menambah minat masyarakat terhadap Jurusan Sistem Komputer Universitas Diponegoro, dan juga mempermudah pengguna untuk melakukan ujian secara online dan tidak perlu menggunakan alat tulis untuk melakukan pengerjaan.
Perancangan Aplikasi Toko Online "XO-Licious" Berbasis Mobile Web pada Sistem Operasi Android
Authors: Arviningrum Alifvia , Satoto Kodrat Iman , Kridalukmana Rinta 
Published: October 2020

XO-Licious merupakan sebuah toko online yang bergerak dalam bidang penjualan original CD, official maupun unofficial goods para penyanyi di Asia. Sasaran penjualan dari toko online ini adalah kalangan muda. Agar tidak kalah bersaing dengan banyaknya toko online yang sekarang ada, maka XO-Licious membutuhkan suatu terobosan yang dapat mempermudah pembeli untuk melakukan transaksi maupun hanya untuk mendapatkan update terbaru.Mobile commerce atau seringkali disebut dengan m-commerce adalah pengembangan sistem perdagangan elektronik (e-commerce) dengan menggunakan peralatan portabel/mobile seperti telepon genggam, Smart Phone, PDA, atau Notebook. Aplikasi mobile commerce yang dibangun adalah aplikasi mobile yang dapat berjalan pada sistem operasi android. Karena saat ini android telah menguasai pasar smartphone dan merupakan sistem operasi open source yang mudah untuk dikembangkan. Framework yang digunakan dalam pembuatan m-commerce ini adalah jQuery Mobile dan PhoneGap. Framework – framework tersebut tersebut dipilih karena memiliki banyak fitur yang menarik seperti, tampilan jQuery mobile dapat menyesuaikan layar dari perangkat bergerak. Sedangkan PhoneGap merupakan sebuah framework opensource yang digunakan untuk membuat aplikasi cross-platform mobile hanya dengan menggunakan bahasa pemrograman HTML , JavaScript dan CSSMobile commerce yang berbasis mobile web akan sangat cocok untuk XO-Liciou. Aplikasi mobile commerce ini dapat mempermudah pelanggan/pembeli untuk memesan barang dari XO-Licious dimanapun dan kapanpun melalui smartphone atau tablet yang telah menjadi gaya hidup remaja saat ini.
Problemy i potrzeby uczniów klas IV szkoły podstawowej w relacjach z rówieśnikami
Authors: Deptuła Maria , Borucka Anna 
Published: October 2020

Deptuła Maria, Borucka Anna, Problemy i potrzeby uczniów klas IV szkoły podstawowej w relacjach z rówieśnikami [Problems and Needs of 4th Grade Students in their Relations with Peers]. Studia Edukacyjne nr 56, 2020, Poznań 2020, pp. 57-84. Adam Mickiewicz University Press. ISSN 1233-6688. DOI: 10.14746/se.2020.56.4The aim of the paper is to present the results of longitudinal questionnaire surveys carried out amongstudents of the 4th grade on their problems and needs in relations with peers. Method: Students from 17 classes from all IV grades existing in the 2017/2018 school year in public schools in Bydgoszcz took part in the study. An anonymous questionnaire containing 21 closed-end questions and open questions regarding the relationship with peers and teachers was used.
Results: The qualitative analysis was used to distinguish categories of students’ statements, whichreferred to individual experiences related to (1) functioning among peers and (2) the social climate ofthe school.Quantitative analyses did not show any correlation between student statements and variables relatedto the school environment. In contrast, there was a correlation between the frequency of statementsabout changes in the class and the wishes related to the desirable behavior towards the respondentand the quality of the conditions of psychosocial development in relation with peers.