bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ankle Joint Injuries Accompanying Fifth Metatarsal Base Fractures
Authors: Turgut Ali , Uzakgider Melikşah , Altun Ozan , Egeli Ercüment , Erkuş Serkan , Kalenderer Önder 
Published: September 2020

Background
Fifth metatarsal base fractures are the most commonly seen fractures of the foot. Ankle sprains occur with inversion and plantarflexion mechanisms, similar to most fifth metatarsal base fractures. We sought to investigate the possible ankle injuries that accompany fifth metatarsal base fractures.

Methods
A hospital's digital database was searched for the International Classification of Diseases, Tenth Revision codes for metatarsal bone fractures (codes S92.30 and S92.35) between January 2015 and January 2018. Thirty-nine patients with fifth metatarsal base fracture who underwent ankle magnetic resonance imaging (MRI) within 14 days of injury were included in the study. The MRI findings were evaluated, and comparisons were performed according to fracture zone, sex, and age.

Results
The most common MRI finding was talocrural joint effusion, which was observed in 28 patients (71.8%). Bone marrow edema was observed in 16 patients (41.0%). Chondral injury at the medial dome of talus was observed in three patients (7.7%). Grade 1 ligament sprain was observed in six patients (15.4%): two in the lateral ligament and four in the deltoid ligament.

Conclusions
Although most fifth metatarsal base fractures and ankle sprains occur as a result of a common mechanism, physical examination findings and patients' complaints are very important. Routine MRI should be unnecessary for most patients. If a patient with a fifth metatarsal base fracture has complaints about the ankle joint, one should be aware of bone marrow edema, which was observed in 41.0% of the study population.
Assessment of Balance Nutrition (N, P, K, Zn and B) and Green Manuring on Yield, Nutrient Uptake, Economics and Soil Fertility of Rainfed Rice (Oryza sativa L.) in Drought Prone Areas of Odisha
Authors: Udgata J. , Barik M. , Phonglosa A. , Joshi S. K. , Mishra P. J. , Rahman F. H. , Garnayak L. M. , Parida D. 
Published: September 2020

A field experiment was carried out in participatory mode on farmers’ field at Bhoimunda village of Jharsuguda block under Jharsuguda district, Odisha during Kharif season of 2017, 2018 and 2019 to study the efficiency of nutrient management along with green manuring crop on productivity, profitability and soil fertility of rice under Western Central Table Land Zone of Odisha, India. The adopted village was selected by Krishi Vigyan Kendra, Jharsuguda, Odisha under National Innovations in Climate Resilient Agriculture (NICRA) project. The experiment was laid out in Randomized Block Design with four treatments replicated five times taking rice (cv. Sahabhagi dhan) as test crop. The treatments comprised of four viz. T1: Farmer’s practice (NPK @ 50:20:20 kg ha-1), T2: Recommended dose of fertilizer (NPK @ 60:30:30 kg ha-1), T3: 75% RDF + Green manuring of dhaincha (Sesbania aculeata) with seed rate of @ 25 kg ha-1 and T4: Soil Test Based NPKZnB @ 75:38:30:6.25:1.25 kg ha-1 + Green manuring. Results revealed that application of Soil Test Based NPKZnB @ 75:38:30:6.25:1.25 kg ha-1 along with green manuring producing dry biomass 5044 kg ha-1 (T4) recorded significantly higher growth and yield attributes, grain yield (4.04 t ha-1), straw yield (5.15 t ha-1), harvest index (43.92%) as well as nutrient uptake in grain and straw of the crop over farmers practice. The same treatment recorded significant improvement in soil pH, organic carbon, available macronutrients (N, P and K) and micronutrients (Zn and B) status of soil after harvest of the crop. The highest benefit: cost ratio (1.62) and returns (Rs. 28559 ha-1) were recorded with the same treatment (T4) over farmers practice. The present study showed that use of green manuring along with balance nutrition, is an important strategy to maintain and/or improve soil fertility for sustainable crop production in drought prone areas as well as remunerative rice production by the farmers in Odisha, India.
Land Use/Land Cover Change of Rabi Season of Rahuri Taluka of Ahmednagar District Maharashtra
Authors: Mahadule Payal A. , Atre A. A. , Kamble Ankita P. , Pande C. , Gorantiwar S. D. 
Published: September 2020

Advanced change location procedures by utilizing multi-temporal satellite symbolism helps in understanding landscape dynamics. The present examination shows the spatio- temporal elements of land use of Rahuri Taluka, Ahmednagar District, Maharashtra, India. Sentinel 2A satellite imageries of four different months of Rabi season (2019-2020) were acquired by United States Geological Survey (USGS) earth explorer site and quantify the changes in the Rahuri Taluka from October 2019 to January 2020 over a period of 3 months.This study applied supervised classification-maximum likelihood algorithm by using Arc GIS 10.1 Map envision to distinguish land use changes of Rahuri. Land Use/Land Cover (LULC) in the Rahuri has experienced a progression of changes in the course of the last three months. Four significant LULC classes viz; Water body, Built-up Land, Waste/Fallow land, Agriculture land have been distinguished and demonstrate that significant land use in the Rahuri Taluka. Results appears, water bodies was highest in month of October 15.68% (166.48 km2), Agriculture land was highest in month of November 59.77% (634.56 km2) and Waste/Fallow land was significantly higher in month of October 41.1% (437.47 km2) and December 41.7% (442.77 km2) than November 30.54% (324.28 km2). The examination and discoveries of the investigation features significant approach suggestions for the maintainable Land Use/Land Cover the board in the Rahuri.
Detection of H. pylori IgG by Using ELISA
Authors: Mahato Malabika 
Published: September 2020

Background: Helicobacter pylori is a Gram-negative, winding, microaerophilic human pathogen and have indicated solid relationship with different gastroduodenal illnesses. Its contagion is one of the most widely recognized interminable diseases in humans since the isolation of the pathogen (1–3).
Aim and Objectives: This examination was directed to discover the affectability and particularity of ELISA in distinguishing H. pylori.
Materials and Methods: The investigation was completed in the Department of Pathology, Sri Balaji Medical College and Hospital, Chennai for a period from November 2016 to October 2018. The research was planned as Prospective study. The study recruited two population of respondents comprising of 50 symptomatic clinicians and 50 infection populations of either sex, over 18 years of age. Patients with signs identified with the upper gastrointestinal tract prompted by endoscopic examination and identified as having gastritis, peptic ulcer (PU) and those patients were recalled for this investigation. Patients who took treatment of pylori destruction and use of antimicrobial agents, neutron siphon agonists, bismuth containing mixtures during the month prior to endometrial biopsy were removed from the inquiry. All essential history, clinical breakthroughs and research facility records of each subject were methodically documented in Microsoft windows sensitive Excel sheet for the consequent examination. Arterial blood samples were collected for the Enzyme Linked Immunosorbent Assay (ELISA) test. For this, 50 people of either sex matured over 18 years of age were considered.
Results: It was observed that, the normal age of the patient was 40 to 60 years, 56% of them were male and 44% female. In this examination, serology tests to recognize IgG counter acting agent demonstrated the affectability of (60%). By and large, low precision and affectability of IgG serological tests is because of the failure to separate among present and past disease. Conclusion: These examinations show that H. pylori contamination is a typical issue among individuals in tamilnadu, India. The titer of IgG antibodies to H. pylori in serum can be utilized as non-intrusive tests for the presence of gastritis.
Comparative Study of Clinico-Pathological Profiles of Patients with Proximal Versus Distal Gastric Adenocarcinoma
Authors: Krishnamoorthy Ashwini , Rajkumar Shreya , Kuberan K. 
Published: September 2020

Background: Stomach adenocarcinoma has been a major source of malignant development through the greater part of the 20th century. In different parts of the world, the prevalence of this disease has decreased, mostly due to changes in diet and some other natural constituents.
Aim: To examine the clinical pathology of patients with proximal and distal gastric adenocarcinomas.
Methodology: This was the prospective work carried out with gastric adenocarcinoma patients treated at Sree Balaji Medical College and Hospital (SBMCH), Chennai, Tamilnadu, India. All patients were undergone upper gastrointestinal endoscopy and an imaging. In endoscopy, biopsies will be taken from the lesion and biopsies were subjected to histopathological examination.
Results: The most striking epidemiologic perceptions were the increasing frequency of adenocarcinomas of the proximal stomach and distal throat. We found that the occurrence of proximal gastric adenocarcinomas isn't expanding in our populace when contrasted with the rising rate of such proximal tumors in the Western Hemisphere.
Conclusion: In our investigation distal gastric adenocarcinomas were a more incessant finding than the proximal gastric adenocarcinomas.
Tofacitinib in Patients With Psoriatic Arthritis and Metabolic Syndrome: A Post hoc Analysis of Phase 3 Studies
Authors: Ritchlin Christopher T. , Giles Jon T. , Ogdie Alexis , Gomez‐Reino Juan J. , Helliwell Philip , Young Pamela , Wang Cunshan , Wu Joseph , Romero Ana Belén , Woolcott John , Stockert Lori 
Published: September 2020

ObjectiveMetabolic syndrome (MetS) is a cluster of concurrent risk factors for cardiovascular disease and type 2 diabetes. This post hoc analysis explored key efficacy and safety endpoints in patients with psoriatic arthritis (PsA) and MetS treated with tofacitinib.MethodsTofacitinib 5 and 10 mg twice daily and placebo data were pooled from two Phase 3 studies (OPAL Broaden [12 months; ClinicalTrials.gov identifier NCT01877668]; OPAL Beyond [6 months; ClinicalTrials.gov identifier NCT01882439]); patients received one background conventional synthetic disease‐modifying antirheumatic drug. Patients were stratified by baseline presence/absence of MetS. Efficacy and safety were reported to month 3 (tofacitinib and placebo) and 6 (tofacitinib only). Efficacy outcomes included: American College of Rheumatology (ACR)20/50/70, Health Assessment Questionnaire‐Disability Index (HAQ‐DI) response, Psoriasis Area Severity Index (PASI)75 response, and enthesitis/dactylitis resolution rates; and changes from baseline (Δ) in C‐reactive protein, HAQ‐DI, Patient’s/Physician’s Global Assessment of Arthritis, and patient‐reported outcomes. Safety outcomes included treatment‐emergent all‐causality adverse events (AEs), Δ in lipid/hepatic values, and liver parameter increases.ResultsOf 710 patients, 41.4% (n = 294) had baseline MetS. All efficacy outcomes improved with both tofacitinib doses versus placebo, to month 3; tofacitinib efficacy was consistent to month 6, regardless of MetS status. MetS did not appear to affect the incidence of AEs or Δ in lipid/hepatic values with tofacitinib up to month 3 or 6. Arterial thromboembolism and myocardial infarction (adjudicated major adverse cardiovascular events) were each reported once in tofacitinib‐treated patients with MetS.ConclusionRegardless of baseline MetS status, tofacitinib showed greater efficacy versus placebo in patients with active PsA. The tofacitinib safety profile appeared similar in patients with versus without MetS.
High Throughput Screening of Millions of van der Waals Heterostructures for Superlubricant Applications
Authors: Fronzi Marco , Tawfik Sherif Abdulkader , Ghazaleh Mutaz Abu , Isayev Olexandr , Winkler David A. , Shapter Joe , Ford Michael J. 
Published: September 2020

AbstractThe screening of novel materials is an important topic in the field of materials science. Although traditional computational modeling, especially first‐principles approaches, is a very useful and accurate tool to predict the properties of novel materials, it still demands extensive and expensive state‐of‐the‐art computational resources. Additionally, they can often be extremely time consuming. A time and resource efficient machine learning approach to create a dataset of structural properties of 18 million van der Waals layered structures is described. In particular, the authors focus on the interlayer energy and the elastic constant of layered materials composed of two different 2D structures that are important for novel solid lubricant and super‐lubricant materials. It is shown that machine learning models can predict results of computationally expansive approaches (i.e., density functional theory) with high accuracy.
Eliciting Language Samples for Analysis (ELSA): A New Protocol for Assessing Expressive Language and Communication in Autism
Authors: Barokova Mihaela D. , La Valle Chelsea , Hassan Sommer , Lee Collin , Xu Mengyuan , McKechnie Riley , Johnston Emily , Krol Manon A. , Leano Jennifer , Tager‐Flusberg Helen 
Published: September 2020

AbstractExpressive language and communication are among the key targets of interventions for individuals with autism spectrum disorder (ASD), and natural language samples provide an optimal approach for their assessment. Currently, there are no protocols for collecting such samples that cover a wide range of ages or language abilities, particularly for children/adolescents who have very limited spoken language. We introduce a new protocol for collecting language samples, eliciting language samples for analysis (ELSA), and a novel approach for deriving basic measures of verbal communicative competence from it that bypasses the need for time‐consuming transcription. Study 1 presents ELSA‐adolescents (ELSA‐A), designed for minimally and low‐verbal older children/adolescents with ASD. The protocol successfully engaged and elicited speech from 46 participants across a wide range of ages (6;6–19;7) with samples averaging 20–25 min. The collected samples were segmented into speaker utterances (examiner and participant) using real‐time coding as one is listening to the audio recording and two measures were derived: frequency of utterances and conversational turns per minute. These measures were shown to be reliable and valid. For Study 2, ELSA was adapted for younger children (ELSA‐Toddler [ELSA‐T]) with samples averaging 29 min from 19 toddlers (2;8–4;10 years) with ASD. Again, measures of frequency of utterances and conversational turns derived from ELSA‐T were shown to have strong psychometric properties. In Study 3, we found that ELSA‐A and ELSA‐T were equivalent in eliciting language from 17 children with ASD (ages: 4;0–6;8), demonstrating their suitability for deriving robust objective assessments of expressive language that could be used to track change in ability over time. We introduce a new protocol for collecting expressive language samples, ELSA, that can be used with a wide age range, from toddlers (ELSA‐T) to older adolescents (ELSA‐A) with ASD who have minimal or low‐verbal abilities. The measures of language and communication derived from them, frequency of utterances, and conversational turns per minute, using real‐time coding methods, can be used to characterize ability and chart change in intervention research.Lay SummaryWe introduce a new protocol for collecting expressive language samples, ELSA, that can be used with a wide age range, from toddlers (ELSA‐T) to older adolescents (ELSA‐A) with autism spectrum disorder who have minimal or low‐verbal abilities. The measures of language and communication derived from them, frequency of utterances and conversational turns per minute, using real‐time coding methods, can be used to characterize ability and chart change in intervention research.
Synthesis, Structure and Catalytic Properties of Faceted Oxide Crystals
Authors: Zhao Xiaohui , Susman Mariano D. , Rimer Jeffrey D. , Bollini Praveen 
Published: September 2020

AbstractBulk metal oxide catalysts are key components of numerous large‐scale industrial processes that possess a high degree of complexity in bulk and surface structure. Such complexity manifests itself in the form of large uncertainties with respect to the nature, density, and efficacy of active sites responsible for catalytic turnovers. Faceted oxide crystals present the prospect of exposing well‐defined oxide surfaces while also being amenable for investigation at realistic pressures and temperatures. Despite the opportunity faceted oxide crystals present for developing more rigorous relationships between atomic‐level structure and catalytic function, their use remains far less prevalent compared to their metallic counterparts. This review, focused on cuprous oxide and cerium oxide crystals, seeks to examine and highlight challenges in controlling and rationalizing metal oxide crystallization, as well as limitations preventing elucidation of the relationships between atomic‐level structures and catalytic properties. We postulate that a clearer understanding of these challenges will encourage researchers to further pursue the study of catalytic properties of faceted oxide crystals, aiding not only an enhanced molecular‐level knowledge of bulk oxide catalysis, but also the development of improved materials for large‐scale catalytic processes.
An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells
Authors: Meier‐Menches Samuel M. , Neuditschko Benjamin , Zappe Katja , Schaier Martin , Gerner Marlene C. , Schmetterer Klaus G. , Del Favero Giorgia , Bonsignore Riccardo , Cichna‐Markl Margit , Koellensperger Gunda , Casini Angela , Gerner Christopher 
Published: September 2020

AbstractThe organometallic AuI bis‐N‐heterocyclic carbene complex [Au(9‐methylcaffeine‐8‐ylidene)2]+ (AuTMX2) was previously shown to selectively and potently stabilise telomeric DNA G‐quadruplex (G4) structures. This study sheds light on the molecular reactivity and mode of action of AuTMX2 in the cellular context using mass spectrometry‐based methods, including shotgun proteomics in A2780 ovarian cancer cells. In contrast to other metal‐based anticancer agents, this organogold compound is less prone to form coordinative bonds with biological nucleophiles and is expected to exert its drug effects mainly by non‐covalent interactions. Global protein expression changes of treated cancer cells revealed a multimodal mode of action of AuTMX2 by alterations in the nucleolus, telomeres, actin stress‐fibres and stress‐responses, which were further supported by pharmacological assays, fluorescence microscopy and cellular accumulation experiments. Proteomic data are available via ProteomeXchange with identifier PXD020560.
Short‐term decline of Castanopsis fargesii adult trees promotes conspecific seedling regeneration: The complete process from seed production to seedling establishment
Authors: Huang Li , Zhou Lihua , Wang Jingmei , Jin Cheng , Hu Siwei , Qian Shenhua , Lin Dunmei , Zhao Liang , Yang Yongchuan 
Published: September 2020

AbstractDeclining forests usually face uncertain regeneration dynamics and recovery trajectories, which are challenging to forest management. In this study, we investigated the decline pattern of Castanopsis fargesii and examined the effects on conspecific seedling regeneration. We found that 61.45% of adult individuals were in decline and the smaller DBH size classes of trees (10–40 cm) had a greater probability of decline. Most of the intermediate decline (94.52%) and nondecline individuals (95.23%) did not worsen, and the crowns of 21.91% of the intermediate decline trees were recovered during 2013–2018. Adult tree decline had a negative effect on seed production (mean mature seed density of nondecline, intermediate decline, and high decline individuals was 167.3, 63.3, and 2.1 seeds/m2, respectively), but no effect on key seed traits. The seed survival rate of declining trees was greater than that of nondeclining trees at both the seed production and seed dispersal stages. The seed to seedling transition rates in canopy gaps, decline habitats, and nondecline habitats were 7.94%, 9.47%, and 109.24%, respectively. The survival rate and height growth of newly germinated seedlings were positively correlated with the light condition, which was notably accelerated in the canopy gaps. Taken together, these results indicate that the reduction in seed production of some adult trees had a weakly negative effect on new seedling recruitment, while the improved environmental condition after the decline significantly enhanced the survival and growth of both advanced and new germinated seedlings. Looking at the overall life history, the short‐term defoliation and mortality of some C. fargesii adult trees can be regarded as a natural forest disturbance that favors conspecific seedling regeneration. High‐intensity management measures would be unnecessary in cases of an emerging intermediate decline in this forest.
Recommendations for Palliative and Hospice Care in NCCN Guidelines for Treatment of Cancer
Authors: Mo Li , Urbauer Diana L , Bruera Eduardo , Hui David 
Published: September 2020

Abstract

Background
Integration of specialist palliative care into routine oncologic care improves patients’ quality of life and survival. National Comprehensive Cancer Network (NCCN) cancer treatment guidelines are instrumental in standardizing cancer care, yet it is unclear how palliative and hospice care are integrated in these guidelines. In this study, we examined the frequency of occurrence of “palliative care” and “hospice care” in NCCN guidelines and compared between solid tumor and hematologic malignancy guidelines.

Materials and Methods
We reviewed all 53 updated NCCN Guidelines for Treatment of Cancer. We documented the frequency of occurrence of “palliative care” and “hospice care,” the definitions for these terms if available, and the recommended timing for these services.

Results
We identified a total of 37 solid tumor and 16 hematologic malignancy guidelines. Palliative care was mentioned in 30 (57%) guidelines (24 solid tumor, 6 hematologic). Palliative care was mentioned more frequently in solid tumor than hematologic guidelines (median, 2 vs. 0; p = .04). Among the guidelines that included palliative care in the treatment recommendation, 25 (83%) only referred to NCCN palliative care guideline. Specialist palliative care referral was specifically mentioned in 5 of 30 (17%) guidelines. Only 14 of 24 (58%) solid tumor guidelines and 2 of 6 (33%) hematologic guidelines recommended palliative care in the front line setting for advanced malignancy. Few guidelines (n = 3/53, 6%) mentioned hospice care.

Conclusion
“Palliative care” was absent in almost half of NCCN cancer treatment guidelines and was rarely discussed in guidelines for hematologic malignancies. Our findings underscored opportunities to standardize timely palliative care access across NCCN guidelines.

Implications for Practice
Integration of specialist palliative care into routine oncologic care is associated with improved patient outcomes. National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology have an important role to standardize palliative care involvement for cancer patients. It is unclear how often palliative care referral is recommended in these guidelines. In this study involving 53 NCCN Guidelines for Treatment of Cancer, the researchers found that palliative care was not mentioned in over 40% of NCCN guidelines and was rarely discussed in guidelines for hematologic malignancies. These findings underscored opportunities to standardize timely palliative care access across NCCN guidelines.