bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between polymorphism in BMP15 and GDF9 genes and impairing female fecundity in diabetes type 2
Authors: Al-Thuwaini Tahreer 
Published: July 2020

Abstract
Background
A shortened reproductive period and earlier menopause have been associated with type 2 diabetes. Growth differentiation factor 9(GDF9) and bone morphogenetic protein 15 (BMP15) gene mutations have been associated with earlier menopause. Therefore, this study aimed to evaluate the association between BMP15 and GDF9 mutations with impairing female fecundity in diabetic patients. The study subjects comprised 90 female diabetic patients and 60 female healthy controls. The physio-biochemical analysis was measured using enzymatic determination. A single-strand conformation polymorphism (SSCP) protocol was utilized to assess the pattern of genetic variations.

Results
Genotyping analysis of the BMP15 gene showed a heterogeneous pattern with the presence of two genotypes: AA and AC genotypes. Five novel missense single nucleotide polymorphisms (SNPs) were identified in the BMP15 gene: four SNPs detected in both genotypes, and Met4Leu, a specific SNP, was detected only in the AC genotype. Cumulative in silico tools indicated a highly deleterious effect for the Met4Leu on the mutant protein structure, function, and stability. Diabetes patients showed a significantly higher frequency of genotype AC. The physio-biochemical analysis of fasting plasma glucose (FBG), glycosylated hemoglobin (HbA1c), and luteinizing hormone (LH) were significantly higher (P < 0.05) in AC genotype than AA genotype.

Conclusions
The current research provides the first indication regarding the tight association of BMP15 polymorphism with the impairing female fecundity in the diabetic. A pivotal role is played by the novel (Met4Leu) SNP that can be used as a predictor for the impairing female fecundity of diabetes, while no polymorphism was found in exon 4 of the GDF9 gene.
Early and frequent exposure to antibiotics in children and the risk of obesity: systematic review and meta-analysis of observational studies
Authors: Srivastava Archita , Chau Kim , Kwon Henry , Guo Qin , Johnston Bradley C. 
Published: July 2020

Background: This study aimed to systematically evaluate the available evidence on prenatal and early infancy antibiotic exposure and the association with overweight and obesity in later childhood. Methods: We conducted a comprehensive search of Embase, MEDLINE, and Web of Science for observational studies assessing prenatal and early antibiotic exposure on the risk of overweight and obesity. We independently assessed the risk of bias using the ROBINS instrument and the overall quality of evidence using the GRADE approach. Results: Our search identified thirteen observational studies including 554,983 participants; most studies were at moderate risk of bias. We found a statistically significant impact of early antibiotic exposure and the risk of being overweight later in childhood (OR 1.18; 95% CI 1.05 to 1.34) (very low quality evidence). We also found that early childhood antibiotic exposure was associated with the risk for childhood obesity (OR 1.14; 95% CI 1.04 to 1.24) (very low quality evidence). Conclusions: Very low quality evidence suggests that exposure to antibiotics early in life may be associated with an increased risk of being overweight and obese in later childhood. However, very low quality evidence raises serious questions about the plausibility of prenatal and early infancy antibiotic exposure being causally related to weight in children. PROSPERO registration: CRD42016050011 (14/12/2016)
Raccontare il manicomio: La macchina narrativA di Basaglia fra parole e immagini, Marina Guglielmi (2018)
Authors: Mecchia Giuseppina 
Published: July 2020

Review of: Raccontare il manicomio: La macchina narrativA di Basaglia fra parole e immagini, Marina Guglielmi (2018)
Firenze: Franco Cesati Editore, 179 pp.,
ISBN 978-8-87667-726-7, p/bk, €28.00
Prevalência de Transtornos Depressivos em Estudantes do Curso de Medicina no Brasil / Prevalence of depressive disorders in medical students in Brazil
Authors: Rodrigues Fernanda Odete Souza , Vasconcelos Henrique Guimarães , Nogueira Miriam Barbosa 
Published: July 2020

Objetivo: Analisar a prevalência do transtorno depressivo em acadêmicos de medicina conforme idade, sexo e período do curso em que se encontravam. Métodos: Revisão sistemática de artigos publicados nos últimos 15 anos nas bases de dados PubMed, LILACS e Google Acadêmico, dentre os quais sete estudos corresponderam aos critérios de inclusão pré-estabelecidos nesta pesquisa. Resultados: A prevalência de sintomas depressivos variou entre 8,9% e 79%, sendo as mulheres mais acometidas pelo transtorno. Foram considerados como fatores desencadeantes a carga horária excessiva, amplo conteúdo programático e insegurança quanto à aprendizagem e ao desempenho nas avaliações curriculares e provas de residência. Considerações finais: A jornada acadêmica, desde a preparação para o vestibular até o internato, impacta significativamente na saúde psicológica dos estudantes de medicina. Embora a prevalência da depressão nesses alunos seja superior à média da população geral, a busca por assistência psicológica pelos acadêmicos é, ainda, insatisfatória. Palavras-chave: Saúde Mental, Transtorno Depressivo, Estudantes de Medicina.
Salas Multisseriadas: os desafios da Educação Básica / Multiseries Rooms: Basic Education Challenges
Authors: Nascimento Danielle Ferreira do , Miguel Joelson Rodrigues 
Published: July 2020

O presente estudo objetivou uma discussão sobre as Salas Multisseriadas: os desafios da Educação Básica. A metodologia consistiu em revisão integrativa com os seguintes aportes teóricos de autores como: Costa (2018); Martins; Dias e Silva (2016); Monteiro et al. (2017); Santos e Santos (2017); Freire, (2007); Hage (2006); Oliveira; Santos e Souza (2017), e demais pesquisadores, educadores e profissionais que atuam e defendem uma melhoria tanto para a educação na zona rural, quanto nos métodos e metodologias utilizadas nas salas de ensino multisseriadas. Os resultados parecem indicar uma maior necessidade de mobilização dos professores por capacitação adequada a essa nova demanda didática, bem como por programas educacionais que visem atender as necessidades das escolas do campo ou que tenham classes multisseriadas.
Concepções Pedagógicas e Adequações Curriculares nas Escolas do Campo / Pedagogical Conceptions and Curricular Adaptations in Rural Schools
Authors: Magalhães José Gilmar , Miguel Joelson Rodrigues 
Published: July 2020

Uma educação contextualizada se apresenta como de fundamental importância para desmistificar essa realidade no campo, em geral, negativamente difundida. O presente estudo objetivou uma discussão sobre as concepções pedagógicas e adequações curriculares nas escolas do campo. A metodologia consistiu em revisão integrativa com base nos aportes teóricos de autores como Araújo (2017), cuja contribuição evidenciou a necessidade e importância de consolidação de uma base curricular contextualizada com a realidade dos alunos e a importância desses saberes para valorizar e promover o desenvolvimento local; Martins (2000); Nóvoa (1992), ao defender a necessidade do diálogo entre escola e comunidade, na busca de dar sentido ao que se faz a cada instante; Antunes-Rocha (2012) que traz a compreensão de educação e desenvolvimento sustentável para o meio rural e em especial para a região semiárida; Lima e Melo (2016) traz em sua essência a dimensão politizadora da educação, compreendendo-a enquanto instrumento de humanização, libertação e emancipação dos sujeitos do campo. Os resultados nos levaram a crer que a modernidade traz muitos desafios no campo educacional, mas talvez o mais desafiador seja como nos adequar de forma rápida e, diante de tantas demandas novas? É possível que o currículo contextualizado seja uma das alternativas mais viáveis, para se atender a demanda educacional na contemporaneidade.
Formação Continuada de Professores e o Ensino ante as novas tecnologias / Continuing Teacher Education and Teaching practice in the face of new Technologies
Authors: Viana Maria Elisete Ribeiro Pinto , Miguel Joelson Rodrigues 
Published: July 2020

O presente estudo objetivou uma discussão sobre as Formação Continuada de Professores e o Ensino ante as novas tecnologias. A metodologia consistiu em revisão integrativa com os seguintes aportes teóricos de autores como: Moran (2013), Maissiat (2014), Mercado (1999), Moreira (2003), Almeida (2000), Perrenoud (2000), Lévy (2005), Cortela (2016), dentre outros. Os resultados nos levam a concluir que a prática docente deve incrementar a valorização das relações e os processos cognitivos no âmbito escolar, considerando docentes e discentes como sujeitos aprendizes. Para isso, a formação continuada deve ser concebida como uma necessidade, podendo propiciar ao professor maior segurança para lidar com os diversos desafios inerentes a esse novo contexto educacional.
Lynn Stout, Pro-sociality, and the Campaign for Corporate Enlightenment
Authors: Langevoort Donald C. 
Published: July 2020

Abstract
In this brief essay, I want to call something Lynn Stout was passionate about: building a better account (both theoretical and empirical) of human nature and motivation. This was the subject of a book that extended well beyond the corporate world (Cultivating Conscience [2011]) and was implicit in her most complete set of thoughts about corporate governance, The Shareholder Value Myth (2012). Lynn understood that such a behavioral account was needed to support her theory of corporate purpose. The other CONVIVIUM contributions say little about this aspect of her work, so I am bringing her thoughts about human motivation frontstage.
Protection of Patient Confidentiality from a Civil Law Perspective
Authors: Janiszewska Beata 
Published: July 2020

Abstract
The paper analyses the issue of protection of patient confidentiality by means of civil law instruments. Protection of the patient’s interests related to the preservation of medical information beyond the access of unauthorized persons can be realized primarily through the protection of the patient’s right to medical secrecy and the protection of human personal interests in the form of the right to privacy. The study presents the issue of the violation of the patient’s confidentiality and the claims to be made in connection with such violation. A wider reflection is devoted to the issue of a claim for compensation for damage resulting from the violation of the patient’s rights and the infringement of his/her personal rights, as well as the effects of the co-occurring of these claims, both in the material and procedural perspectives.
PENERAPAN AQUAPONIK DAN PENGEMBANGAN BUDIDAYA IKAN LELE PADA UNIT USAHA PONDOK PESANTREN KOTA MALANG
Authors: Halim Abdul , Pratamaningtyas Suslam 
Published: July 2020

Tarbiyatul Iman Islamic Boarding School (PPTI) located on Jalan Perum Srigading Dalam Kav 11 Malang has a catfish breeding business under the name "Catfish PPTI". The catfish farmers group is a partner in the community partnership program (PKM). The partner group is hoping for good management of fish culture production. The appropriate technology is technology in cultivating fish with a "Bionic" system that combines organic fish farming with organic vegetable plants in limited lands, with the intention of feeding and place efficiency and operational costs. The implementation of PKM in Tarbiyatul Iman Islamic Boarding School (PPTI) begins with coordination with the management. PPTI already has 2 catfish ponds which have been managed as they are as learning media for students. With the existence of this PKM, the number of ponds owned by PPTI has become 7 ponds, plus the installation of aquaponics with a pot system and pipes. There are two aquaponic system models implemented in PPTI, namely the first model where vegetables are grown in pots filled with planting media consisting of gravel / zeolite and husks. Pond water is channeled into plant pots which are arranged on top of a pool and flows out into the pond. While the second model is pond water flowed into PVC pipes, where the pipes are perforated and filled with plants that have been planted in a net pot and the water will be re-inserted into the fish pond. AbstrakPondok Pesantren Tarbiyatul Iman (PPTI) yang berlokasi di Jalan Perum Srigading Dalam Kav 11 Malang mempunyai unit usaha budidya ikan lele dengan nama “Lele PPTI”. Kelompok pembudidaya ikan lele ini merupakan mitra program kemitraan masyarakat (PKM). Kelompok mitra mengharapkan manajemen produksi budidaya ikan yang baik. Teknologi tepat guna tersebut adalah teknologi membudidayakan ikan dengan sistem” Bionic” yaitu menggabungkan budidaya ikan secara organik dengan tanaman sayur organik di lahan terbatas, dengan maksud efisiensi pakan, tempat, serta biaya operasional. Pelaksanaan PKM di Pondok Pesantren Tarbiyatul Iman (PPTI) diawali koordinasi dengan para pengurus. PPTI sudah memiliki 2 buah kolam ikan lele yang selama ini dikelola apa adanya sebagai media pembelajaran bagi santri. Dengan adanya PKM ini, jumlah kolam yang dimiliki PPTI menjadi 7 buah kolam, ditambah dengan instalasi aquaponik sistem pot dan pipa. Ada dua model system aquaponik yang diterapkan, yaitu pertama dimana sayuran ditanam dalam pot yang diisi media tanam yang terdiri dari batu kerikil/zeolite dan sekam. Air kolam dialirkan ke pot-pot tanaman yang disusun di atas kolam ikan dan mengalir keluar kembali masuk ke kolam. Model kedua adalah air kolam dialirkan ke dalam pipa-pipa PVC, pipa-pipa tersebut dilubangi dan diisi tanaman yang telah disemaikan pada net pot dan air akan kembali dimasukkan ke dalam kolam ikan.
SEXUALITY CONSTRUCTION IN CINDERELLA STORY: ASH NOVEL
Authors: Taufik Nafisa Zafira , Leiliyanti Eva 
Published: July 2020

ABSTRACT
Recently, there has been a huge increase of sexuality construction studies in literature field including in Young Adult genre. Ash novel is one of young adult genre retelling the classic fairy tale story of Cinderella with the gendering plot twist of the main female character. Instead of construct the main characters to heterosexual, Malinda Lo deconstructs her gender and sexual identity. The aim of this research will focuses on investigating the relationship between the elements of psychosexual development and sexuality construction in the narratives that change the main character’s gender and sexual identity. This research are using 5 stages of development theory by Sigmund Freud and performativity theory by Judith Butler. To analyze the narratives, this research is using deconstruction theory by Jaques Derrida as methodology approach. The gendering process and sexuality construction to lesbian appears in several events that bring the main character questioning the masculine role and construct her identity by the dominant stepmother.
Keywords: Sexuality Construction; Cinderella; Young - Adult Literature; Lesbian; Psychosexual Development; Performativity, Deconstruction.
A CRITICAL DISCOURSE ANALYSIS OF MOHAMAD NASIR’S SPEECH
Authors: Widiastuti Ni Putu Santhi 
Published: July 2020

ABSTRACT
Discourse is a unit of language in which its form is longer than a sentence including the vast majority of everyday communication; in addition, it ussually employes specific kinds of language as well as infromation structures to deliver specific purposes. In order to identify the structure and purpose of a discourse, the present research employed Critical Discourse Analysis (CDA) to analyze an educational speech in May 2nd, 2016 delivered by the Indonesian Ministry of Research, Technology, and Higher Education, Mohamad Nasir in the celebration of the National Education Day of Indonesia. The result of the analysis showed how the speech was constructed in form of macrostructure, superstructure, and microstructure revealed how the social power was used by symbolic elites to invite all parties in educational field to join together in reforming educational system of Indonesia to be better than what had been conducted by previous partisans in the past.
Keywords: Critical Discourse Analysis (CDA); Indonesian Ministry’s speech; educational speech; National Education Day
REDEFINING AUSTRALIAN LANGUAGE CLASSROOM EFFECTIVITY: TOWARDS INTERCULTURAL COMPETENCE IN FOREIGN LANGUAGE LEARNING
Authors: Ningsih Rahmi Yulia , Devina Devina , Febrianti Lifia Yola 
Published: July 2020

ABSTRACT

Global competence has inevitably expanded the way of education conducted in recent year. One key aspect of global competence is the emergence of cultural intelligence in the classroom – as one medium of global competence transfer is through language learning. Interest to learning a foreign language raises in which many people see foreign language learning as the window and door to the world. This paper aims at exploring global competence is delivered and conducted in a Spanish classroom in Brisbane, Australia. Data were gathered through (1) classroom observation (2) questionnaire distributed to the learner and (3) interview with the learners. Finding shows that in the program is perceived as effective and teacher holds the most important factor in the classroom. In addition to being knowledgeable and skillful, a teacher who possesses cultural intelligence is likely to be preferred. Classroom is portrayed as a hub for transfer of knowledge, allowing learners to bring their identity inside the class while learning being exposed to other foreign language.

Keywords: global competence, cultural intelligence, foreign language learning.
ABILITY OF WRITING POETRY USING THE MEDIA PICTURE GRADE STUDENT VIII SMP 1 PSKD JAKARTA PUSAT
Authors: Siagian Rusmi , Rafli Zainal , Attas Siti Gomo 
Published: July 2020

Abstract

This research is a quantitative research that aims to describe the ability to write poetry based on the image media of students of class VIII SMP 1 PSKD JAKARTA PUSAT District. The population of this study consists of 151 students that are put into 5 classes. Sampling is done by using simple random sampling technique with total sample of 109 students. The instrument used is the test used to obtain the data of students' ability in writing poetry. The tests are given in the form of essays. Data analysis techniques used descriptive statistical analysis that describes the results of Writing Poetry Ability using Picture Media.
Based on the descriptive statistic descriptive statistic analysis, the highest score obtained by the students in terms of the structure of the poem builder is 96 and the lowest score is 50 with the average score of 74,09. Thus it can be concluded that the students of grade VIII SMP 1 PSKD JAKARTA PUSAT are able to write poetry based on the media images.

Keywords: writing, poetry, image media.
Pembelajaran IPA yang Efektif dan Menyenangkan bagi Siswa MI
Authors: Sulthon Sulthon 
Published: July 2020

<p>Pembelajaran di dalam kelas merupakan ujung tombak dari seluruh kegiatan pendidikan yang dilakukan oleh guru, keberhasilan guru dalam pembelajaran sangat dipengaruhi oleh beberapa aspek diantaranya performansi guru dalam pembelajaran. Kemampuan guru dalam pembelajaran menjadi syarat mutlak yang harus dipenuhi untuk meningkatkan kualitas pembelajaran. Sedang keberhasilan pembelajaran siswa sangat ditentukan oleh aktivitas siswa dalam proses pembelajaran yang diciptakan guru.</p><p>Dalam pembelajaran IPA, guru harus memanfaatkan berbagai fasilitas dan sumber belajar yang berorientasi pada keterampilan proses dengan mengadakan pengamatan dan penelitian sehingga siswa akan aktif dan kreatif untuk menemukan suatu konsep dalam IPA selanjutnya siswa menjadi aktif dan asyik sehingga belajar IPA akan menyenagkan.</p><p> </p>
PEMBELAJARAN INTEGRATIF OUTBOUND SAINS DAN PAI SEBAGAI INOVASI PEMBELAJARAN DI MADRASAH IBTIDAIYAH
Authors: Nikmah Alfu 
Published: July 2020

<p>Abstrak</p><p>Pembelajaran sains yang ada di madrasah terkesan banyak membebani siswa dengan banyaknya materi yang diberikan oleh guru. Banyaknya materi yang diberikan oleh guru membuat siswa tidak dapat memahami informasi secara tepat dengan tanpa menghubungkan informasi dalam kehidupan sehari-hari. Pemahaman materi sains akan sangat bermakna apabila dikaitkan dengan lingkungan secara aplikatif dalam kehidupan sehari-hari dan mengacu pada kurikulum 2013 metode pembelajaran integratif diterapkan mulai level dasar yaitu sekolah dasar. Artikel ini membahas tentang inovasi pembelajaran integrative IPA dan sains melalui kegiatan outbound. Artikel ini menelah dengan menggunakan metode kajian pustaka dari beberapa sumber. Hasil dari penelitian kepustakaan ini menunjukkan bahwa Pembelajaran integrative antara IPA atau sains dan PAI menjadi suatu inovasi pembelajaran di madrasah yang dapat meningkatkan motivasi belajar siswa. Pembelajarn sains yang diimplemantasikan dengan pembelajaran di luar atau outbound sekarang banyak dikembangkan dalam proses pendidikan. Outbound sains yang mekankan pembelarana secara langsung di lapangan membuat siswa dapat belajar dan berinteraksi secara langsung dengan sekitar atau lingkungan. Kandungan alam yang banyak dipelajari ini sangat bersentuhan secara langsung dengan pembelajaran PAI yang mengkaitkan penciptaan femonema alam terhadap sang pencipta.</p><p>Kata kunci: pembelajaran integrative, <em>out-bound science</em>, inovasi pembelajaran di madrasah</p><p>Abstract</p><p>Science learning in madrasah seemes giving many burden for the students with the amount of materials given by the teacher. The amount of materials given by the teacher makes students can not understand the information appropriately without linking information in everyday life. Understanding of science materials will be very significant when it is associated with the applicative environment in everyday life and refers to the 2013 curriculum which applies integrative learning methods , starts with the basic level, namely the primary school. This article discussed the innovation of learning and integrative learning science through outbound activities and <em>PAI</em> learning. This article was conducted by using the method of literature review of several sources. The Results from the research literature showed that integrative learning of science and <em>PAI</em> is an innovation study in <em>Madrasah</em> which can increase students' motivation. Learning science can be implemented on the outside or outbound learning that now it has been developed in the educational process. Outbound science implemented the learning in the field directly . it enables students to learn and interact directly with the surrounding or environment. The science studies the natural phenomena that is is related to PAI learning which learn the creation of nature against the creator.</p><p>Keywords: integrative learning, out-bound science, innovation learning in madrasah</p>
CHARACTER EDUCATION IN THE FORMATION OF PRE-SCHOOL CHILDREN’S AKHLAK
Authors: Bastomi Hasan 
Published: July 2020

<p align="center"><em> </em><em>Personal figure of character was not only smartphone born inward, but also has the power to execute something is right. Efforts need to implementation of character education. Character education has higher </em><em>meaning </em><em>than the moral education and ha</em><em>s</em><em> electrostatic formation of morals. Preschool-age children can </em><em>be </em><em>already given the character education by enabling the empathy toward children who already exists, which is part of conscience. In relation to the education characters need to be delicately six character value contains about the following materials: (1) teach the love of God and all His creation, (2) independence, (3) honest, (4) responsibility, (5) tolerance, (6) </em><em>cooperating</em><em>, etc. and that they are all the elements in the good character (akhlaqul karimah).</em></p>