bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complementary medicine in orthopaedic and trauma surgery: a cross-sectional survey on usage and needs
Authors: Kilper Anica , Müller Alexander , Huber Roman , Reimers Niklas , Schütz Ludwig , Lederer Ann-Kathrin 
Published: September 2020

ObjectivesComplementary and alternative medicine (CAM) is frequently used in Western countries within general medicine and internal medicine. Information on the use in orthopaedic and trauma surgery is widely lacking. The aim of this study was to investigate usage and needs regarding CAM for these patients.DesignProspective paper-based, pseudoanonymous, cross-sectional survey.SettingFrom August to December 2018, a questionnaire composed of 17 questions was distributed to all eligible patients.ParticipantsIn-house patients in orthopaedic and trauma surgery at a high-volume medical centre in Germany.Primary and secondary outcome measuresPrevious or current usage of CAM, interest and requests towards CAM as well as communication about CAM.ResultsOverall, 457 orthopaedic and trauma surgical patients took part in the survey. They were on average 52 years old and 54% were male. Most of the patients were admitted due to bone fractures and most underwent operative therapy. Previous or current CAM usage was stated by 76% and 30% of patients, respectively. Most of the patients stated to be interested in usage of CAM and demanded for more clinical usage of CAM and reliable information about CAM. More than 90% of patients did not discuss CAM interest or usage with their treating physicians. Patients stated that physicians should have knowledge about CAM. They wish to be treated in a holistic manner and want to strengthen self-efficacy.ConclusionsUsage of CAM of patients in orthopaedic and trauma surgery appears to be high. Only a few patients discuss their interest and usage of CAM with their treating physician. Therefore, surgeons should ask their patients about CAM and should consider evidence-based CAM approaches for complementary treatment.Trial registration numberDRKS0001544.
Factors associated with fear of hypoglycaemia among the T1D Exchange Glu population in a cross-sectional online survey
Authors: Liu Jingwen , Bispham Jeoffrey , Fan Ludi , Poon Jiat-Ling , Hughes Allyson , Mcauliffe-Fogarty Alicia , Varnado Oralee , Mitchell Beth 
Published: September 2020

ObjectivesFear of hypoglycaemia (FoH) has been associated with suboptimal diabetes management and health outcomes. This study investigated factors associated with behavioural and emotional aspects of FoH among adults living with type 1 diabetes (T1D) mellitus.DesignCross-sectional study.SettingOnline survey hosted on T1D Exchange Glu, an online community for patients living with T1D mellitus.MeasuresThe Hypoglycaemia Fear Survey II-short form and the Hypoglycaemic Attitudes and Behaviour Scale were used to assess FoH. Multivariable regressions were performed on assessment scores.ResultsThe study included 494 participants (mean±SD age 43.9±12.2 years, duration of T1D mellitus 16.6±16.8 years, self-reported glycosylated hemoglobin (HbA1c) 6.9%±0.8% (52±9 mmol/mol)), 63% men, 89% on insulin pump, 25% experienced a severe hypoglycaemic event in the last 6 months. Multivariable regression analyses showed higher anxiety, depression severity and diabetes distress were independently associated with FoH (all p<0.01). Longer diabetes duration was associated with lower FoH (p<0.01). Past experience with severe hypoglycaemia was associated with higher worry of hypoglycaemia (p<0.01) but not avoidance behaviour (ns).ConclusionsThese results highlighted the multifaceted nature of FoH, which warrants further discussion between providers and patients to uncover drivers of and actions required to reduce FoH and improve patient care and outcomes.
Epidemiology and determinants of non-diabetic hyperglycaemia and its conversion to type 2 diabetes mellitus, 2000–2015: cohort population study using UK electronic health records
Authors: Ravindrarajah Rathi , Reeves David , Howarth Elizabeth , Meacock Rachel , Soiland-Reyes Claudia , Cotterill Sarah , Whittaker William , Heller Simon , Sutton Matt , Bower Peter , Kontopantelis Evangelos 
Published: September 2020

ObjectivesTo study the characteristics of UK individuals identified with non-diabetic hyperglycaemia (NDH) and their conversion rates to type 2 diabetes mellitus (T2DM) from 2000 to 2015, using the Clinical Practice Research Datalink.DesignCohort study.SettingsUK primary Care Practices.ParticipantsElectronic health records identified 14 272 participants with NDH, from 2000 to 2015.Primary and secondary outcome measuresBaseline characteristics and conversion trends from NDH to T2DM were explored. Cox proportional hazards models evaluated predictors of conversion.ResultsCrude conversion was 4% within 6 months of NDH diagnosis, 7% annually, 13% within 2 years, 17% within 3 years and 23% within 5 years. However, 1-year conversion fell from 8% in 2000 to 4% in 2014. Individuals aged 45–54 were at the highest risk of developing T2DM (HR 1.20, 95% CI 1.15 to 1.25— compared with those aged 18–44), and the risk reduced with older age. A body mass index (BMI) above 30 kg/m2 was strongly associated with conversion (HR 2.02, 95% CI 1.92 to 2.13—compared with those with a normal BMI). Depression (HR 1.10, 95% CI 1.07 to 1.13), smoking (HR 1.07, 95% CI 1.03 to 1.11—compared with non-smokers) or residing in the most deprived areas (HR 1.17, 95% CI 1.11 to 1.24—compared with residents of the most affluent areas) was modestly associated with conversion.ConclusionAlthough the rate of conversion from NDH to T2DM fell between 2010 and 2015, this is likely due to changes over time in the cut-off points for defining NDH, and more people of lower diabetes risk being diagnosed with NDH over time. People aged 45–54, smokers, depressed, with high BMI and more deprived are at increased risk of conversion to T2DM.
Predicting the need for retreatment in venous sinus stenting for idiopathic intracranial hypertension
Authors: Kahan Joshua , Sundararajan Sri , Brown Kenroy , Dinkin Marc , Oliveira Cristiano , Patsalides Athos 
Published: September 2020

Background
Idiopathic intracranial hypertension is a disease of raised intra-cranial pressure of unknown etiology. Lateral cerebral venous sinus stenosis (VSS) has been increasingly reported in these patients, and stenting has emerged as an alternative treatment for medically refractory symptoms. Treatment efficacy on meta-analysis appears promising, but identifying which patients are likely to benefit most, and which are likely to require repeat procedures, is currently unclear.

Methods
We retrospectively reviewed a prospectively collected database of 79 patients treated with venous sinus stenting at a single academic center with minimum follow-up of 18 months. We extracted baseline clinical data, as well as manometry at lumbar puncture and during angiography, and used logistic regression to identify parameters that could predict stent failure.

Results
Retreatment rate after successful VSS was 13.9%. Lumbar puncture opening pressure (OP) was shown to significantly predict treatment failure (ß=0.06; OR=1.064 (1.003–1.135); P=0.039). This effect remained significant when age, sex and body mass index were added to the model (ß=0.06; OR=1.066 (1.002–1.140); P=0.043). OP was correlated with venous sinus manometry readings in the superior sagittal and transverse sinus pre-stent placement, as well trans-stenotic gradient (P<0.001).

Conclusions
Higher lumbar puncture OP was associated with an increased risk of stent failure in transverse sinus stenting for idiopathic intracranial hypertension, although the performance of this model as a linear discriminator was poor. Further studies are required to better assess which patients are at greatest risk of treatment failure.
Feasibility study of a shielding-independent radiation portal monitor system for revealing 241-Am orphan sources in radiometric surveillance of scrap metal
Authors: Zorloni Gabriele , Tancioni Paolo , Caresana Marco 
Published: September 2020

AbstractOrphan radioactive sources inadvertently melted in steel plants are a health and economical hazard. Thus, regulation authorities impose strict control measurements to be performed at these plants. However, a recent series of incidents related to the melting of $${}^{241}\hbox {Am}$$

241

Am

sources demonstrated the inadequacy of even state of the art systems in revealing this low-energy gamma ray emitter up to activities of the order of hundreds GBq. However, $${}^{241}\hbox {Am}$$

241

Am

sources are characterized by a weak neutron emission which can be detected by proper monitor systems. This work provides a feasibility study of a shielding-independent neutron-sensitive portal monitor system to be installed in steel plants. Measurements were performed both with a certified $${}^{241}\hbox {Am}$$

241

Am

shielded source and at the weighing area of a steel plant, to assess both the detector performance and the practical feasibility of the system implementation in work-place fields. A risk evaluation analysis demonstrated that with the current control systems $${}^{241}\hbox {Am}$$

241

Am

sources up to 185 GBq could pass undetected with a potential exposure for workers equal to 1.7 mSv, consistent with recent accidents reports. The proposed technique could reveal $${}^{241}\hbox {Am}$$

241

Am

activities down to 2 GBq, decreasing the worker exposure down to 24 $$\upmu \hbox {Sv}$$

μ
Sv

, without interfering with the standard plant operations.
Renta Básica Universal
Authors: Ponce Carlos 
Published: September 2020

En este artículo se realiza un breve análisis económico relativo a la introducción de una renta básica universal (RBU), una de las propuestas más controvertidas de los últimos tiempos. Existen diversos mecanismos para proveer asistencia social. Es útil caracterizar a los mismos de acuerdo a dos dimensiones. Continuar leyendo...
Bioinformatic analysis reveals hub genes and pathways that promote melanoma metastasis
Authors: Su Wenxing , Guan Yi , Huang Biao , Wang Juanjuan , Wei Yuqian , Zhao Ying , Jiao Qingqing , Ji Jiang , Yu Daojiang , Xu Longjiang 
Published: September 2020

Abstract
Background
Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear.

Methods
With the goal of revealing the underlying mechanism, three data sets with accession numbers GSE8401, GSE46517 and GSE7956 were downloaded from the Gene Expression Omnibus (GEO) database. After identifying the differentially expressed gene (DEG) of primary melanoma and metastatic melanoma, three kinds of analyses were performed, namely functional annotation, protein-protein interaction (PPI) network and module construction, and co-expression and drug-gene interaction prediction analysis.

Results
A total of 41 up-regulated genes and 79 down-regulated genes was selected for subsequent analyses. Results of pathway enrichment analysis showed that extracellular matrix organization and proteoglycans in cancer are closely related to melanoma metastasis. In addition, seven pivotal genes were identified from PPI network, including CXCL8, THBS1, COL3A1, TIMP3, KIT, DCN, and IGFBP5, which have all been verified in the TCGA database and clinical specimens, but only CXCL8, THBS1 and KIT had significant differences in expression.

Conclusions
To conclude, CXCL8, THBS1 and KIT may be the hub genes in the metastasis of melanoma and thus may be regarded as therapeutic targets in the future.
The diagnostic value of homocysteine for the occurrence and acute progression of chronic obstructive pulmonary disease
Authors: Wei Bing , Tian Tian , Liu Yugeng , Li Chunsheng 
Published: September 2020

Abstract
Background
This study aimed to evaluate whether the Homocysteine (Hcy) level was elevated in chronic obstructive pulmonary disease (COPD) patients and its correlation with the occurrence and acute progression of COPD.

Methods
From November 2014 to November 2015, COPD patients were enrolled from Beijing Chao-yang Hospital, and the the biological and clinical data were collected. These patients were tested in the non-acute exacerbation period and the acute exacerbation period, so they were defined as AECOPD group and Non-AECOPD group. Besides, 50 healthy subjects were recruited and defined as control group. Total plasma Hcy levels (antibodies-online, USA) were determined by enzyme-linked immunosorbent assay. Correlation analysis was used to analyze the correlation between serum Hcy level and ventilatory function. Using ROC curve, the diagnostic value of Hcy for the occurrence and acute progression of COPD was explored.

Results
In this study, we found that Hcy levels in the Non-AECOPD group or the AECOPD group were significantly higher than those in the control group (P < 0.001). Meanwhile, compared with the Non-AECOPD group, the Hcy level in the AECOPD group was significantly higher (P < 0.001). In addition, according to the classification of GOLD grade, there was significant difference in the Hcy level among different GOLD grade groups (P < 0.001). The correlation analysis showed that in the AECOPD group and the Non-AECOPD group, Hcy levels presented a negative correlation with FEV1(r < 0). Meanwhile, FEV1% was also negatively correlated with Hcy level (r < 0). ROC curve analysis showed that when the cutoff value was set to 10.8 μg/ml, the specificity, sensitivity and AUC were the best, which were 0.980, 0.800, and 0.945, respectively. Besides, our results showed that when the cutoff value was set to 14.0 μg / ml, the specificity, sensitivity and AUC were the best, which were 0.846, 0.680, and 0.802, respectively. In addition, compared with the prediction of acute progression of COPD, when Hcy level predicted the occurrence of COPD, its specificity (0.980 vs. 0.846, P < 0.001) and sensitivity (0.800 vs. 0.680, P < 0.001) were significantly higher.

Conclusion
Hcy level is positively correlated with the severity of COPD patients, which has predictive value for the occurrence of COPD and acute progression.
Inhibiting MAPK14 showed anti-prolactinoma effect
Authors: Ding Qiao-yan , Zhang Yu , Ma Li , Chen Yong-gang , Wu Jin-hu , Zhang Hong-feng , Wang Xiong 
Published: September 2020

Abstract
Background
The specific underlying pathogenesis of prolactinoma has not been clarified yet, to the best of our knowledge. p38 mitogen-activated protein kinase (MAPK) signaling including p38α MAPK (MAPK14), p38β (MAPK11), p38γ (MAPK12) and p38δ (MAPK13) is associated with the development and progression of several types of cancer.

Methods
Immunofluorescence analysis was performed on the prolactin (PRL) and MAPK14 expressions of pituitary gland in C57BL/6 mice and human prolactinoma specimen. In the present study, the role of MAPK14 in prolactinoma was determined using estradiol-induced mice and dopamine D2 receptor knockout (DRD2−/−) mice models in C57BL/6 wild-type (WT), MAPK14−/− and DRD2−/−MAPK14+/− mice. GH3 cells were transfected with different sets of MAPK14 small interfering RNA, which to study MAPK14 and PRL expression in GH3 cells.

Results
Immunofluorescence analysis showed that PRL and MAPK14 expression were colocalized and increased in the pituitary gland of mice and human prolactinoma specimen compared with the control specimen. It was shown that PRL and MAPK14 expression was colocalized and increased significantly in the pituitary gland of estradiol-injected prolactinoma mice compared with the control mice. Knockout of MAPK14 significantly inhibited tumor overgrowth, and PRL expression was decreased in estradiol-induced mice. Furthermore, MAPK14 knockout of DRD2−/−MAPK14+/− mice significantly reduced the overgrowth of pituitary gland and PRL production and secretion compared with DRD2−/− mice. MAPK14 knockout using siRNA inhibited PRL production in GH3 cells.

Conclusion
These results suggest that MAPK14 serves a promoting role in the formation of prolactinoma, and highlights the potential of MAPK14 as a potential therapeutic target in the treatment of prolactinoma.
Pigmented villonodular synovitis does not influence the outcomes following cruciate-retaining total knee arthroplasty: a case-control study with minimum 5-year follow-up
Authors: Lin Wei , Dai Yike , Niu Jinghui , Yang Guangmin , Li Ming , Wang Fei 
Published: September 2020

AbstractBackgroundPigmented villonodular synovitis (PVNS) is a rare synovial disease with benign hyperplasia, which has been successfully treated with total knee arthroplasty (TKA). The purpose of this study was to investigate the middle-term follow-up outcomes of cruciate-retaining (CR) TKA in patients with PVNS.MethodsFrom January 2012 to December 2014, a retrospective study was conducted in 17 patients with PVNS who underwent CR TKA as PVNS group. During this period, we also selected 68 patients with osteoarthritis who underwent CR TKA (control group) for comparison. The two groups matched in a 1:4 ratio based on age, sex, body mass index, and follow-up time. The range of motion, Knee Society Score, revision rate, disease recurrence, wound complications, and the survivorship curve of Kaplan-Meier implant were assessed between the two groups.ResultsAll patients were followed up at least 5 years. There was no difference in range of motion and Knee Society Score between the two groups before surgery and at last follow-up after surgery (p> 0.05). In the PVNS group, no patients with the recurrence of PVNS were found at the last follow-up, one patient underwent revision surgery due to periprosthetic fracture, and three patients had stiffness one year after surgery (17.6% vs 1.5%,p= 0.005; ROM 16–81°), but no revision was needed. At 7 years, the implant survivorship was 90.0% in the PVNS group and 96.6% in the control group (p= 0.54).ConclusionsThis study demonstrated that the function of patients with PVNS who underwent CR TKA had been significantly improved, and the survival rate of implants in these patients was similar to the patients with OA. Consequently, the patients with PVNS who underwent CR TKA might be an achievable option. However, these patients should pay more attention to the occurrence of postoperative stiffness complications.
Characterization of a rhodanese homologue from Haemonchus contortus and its immune-modulatory effects on goat immune cells in vitro
Authors: Wang Yujian , Ehsan Muhammad , Huang Jianmei , Aimulajiang Kalibixiati , Yan RuoFeng , Song XiaoKai , Xu LiXin , Li XiangRui 
Published: September 2020

AbstractBackgroundModulation of the host immune response by nematode parasites has been widely reported. Rhodaneses (thiosulfate: cyanide sulfurtransferases) are present in a wide range of organisms, such as archaea, bacteria, fungi, plants and animals. Previously, it was reported that a rhodanese homologue could be bound by goat peripheral blood mononuclear cells (PBMCs)in vivo.MethodsIn the present study, we cloned and produced a recombinant rhodanese protein originating fromHaemonchus contortus(rHCRD), a parasitic nematode of small ruminants. rHCRD was co-incubated with goat PBMCs to assess its immunomodulatory effects on proliferation, apoptosis and cytokine secretion.ResultsWe verified that the natural HCRD protein localized predominantly to the bowel wall and body surface of the parasite. We further demonstrated that serum produced by goats artificially infected withH. contortussuccessfully recognized rHCRD, which bound to goat PBMCs. rHCRD suppressed proliferation of goat PBMCs stimulated by concanavalin A but did not induce apoptosis in goat PBMCs. The production of TNF-α and IFN-γ decreased significantly, whereas secretion of IL-10 and TGF-β1 increased, in goat PBMCs after exposure to rHCRD. rHCRD also inhibited phagocytosis by goat monocytes. Moreover, rHCRD downregulated the expression of major histocompatibility complex (MHC)-II on goat monocytes in a dose-dependent manner, but did not alter MHC-I expression.ConclusionsThese results propose a possible immunomodulatory target that may help illuminate the interactions between parasites and their hosts at the molecular level and reveal innovative protein species as candidate drug and vaccine targets.
Factors associated with HIV and syphilis screenings among pregnant women at first antenatal visit in Lusaka, Zambia
Authors: Davis Rindcy , Xiong Xu , Althabe Fernando , Lefante John , Cafferata Maria Luisa , Mwenechanya Musaku , Mwanakalanga Friday Habulembe , Chomba Elwyn , Buekens Pierre 
Published: September 2020

Abstract
Objectives
To identify characteristics associated with obtaining HIV and syphilis screenings of pregnant women attending a first antenatal visit in Lusaka, Zambia.

Results
Among 18,231 participants from April 2015 to January 2016, 95% obtained HIV screening, 29% obtained syphilis screening, and 4% did not obtain antenatal HIV or syphilis screenings. Divorced/separated women were associated with a moderate decrease in prevalence of obtaining HIV (adjusted prevalence ratio (aPR) 0.88, 95% confidence interval (95% CI) 0.82, 0.95) and syphilis (aPR 0.51, 95% CI 0.27, 0.96) screenings compared to married women. Women with previous pregnancies were associated with a slight decrease in prevalence of obtaining HIV screening (aPR 0.97, 95% CI 0.95, 0.99) compared to women without previous pregnancy. Older women ≥ 35 years were associated with a slight decrease in prevalence of obtaining HIV screening (aPR 0.96, 95% CI 0.92, 0.99) compared to younger women. The statistically significant differences were not of clinical relevance as defined by a proportional difference of 10 percent. Findings of this study show that a vast majority of pregnant women are obtaining HIV screenings but not syphilis screenings during first antenatal visit. Provision of antenatal HIV and syphilis screening at first visit is only weakly related to patient level factors.
An adversarial learning approach for discovering social relations in human-centered information networks
Authors: Cui Shicheng , Li Qianmu , Chen Shu-Ching 
Published: September 2020

AbstractThe analytics on graph-structured data in cyber spaces has advanced many human-centered computing technologies. However, if only utilizing the structural properties, we might be prohibited from unraveling unknown social relations of nodes especially in the structureless networked systems. Up-to-date ways to unfold latent relationships from graph-structured data are network representation learning (NRL) techniques, but it is difficult for most existing ones to deal with the network-structureless situations due to the fact that they largely depend on the observed connections. With the ever-broader spectrum of human-centered networked systems, large quantities of textual information have been generated and collected from social and physical spaces, which may provide the clues of hidden social relations. In order to discover latent social relations from the accompanied text resources, this paper attempts to bridge the gap between text data and graph-structured data so that the textual information can be encoded to substitute for those incomplete structural information. Generative adversarial networks (GANs) are employed in the cross-modal framework to make the transformed data indistinguishable in graph-domain space and also capable of depicting structure-aware relationships with network homophily. Experiments conducted on three text-based network benchmarks demonstrate that our approach can reveal more realistic social relations from text-domain information compared against the state-of-the-art baselines.