bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 42 mV startup ring oscillator using gain-enhanced self-bias inverters for extremely low voltage energy harvesting
Authors: Matsuzuka Ryo , Terada Tatsuya , Matsumoto Kaori , Kitamura Masatoshi , Hirose Tetsuya 
Published: December 2019

Abstract
This paper presents a ring oscillator (ROSC) capable of operating at an extremely low supply voltage. The proposed ROSC consists of gain-enhanced self-bias inverters. The voltage gain of the proposed inverter is improved by controlling the body bias voltages. Measurements of a prototype chip demonstrated that our proposed ROSC can operate at an extremely low supply voltage of 42 mV.
Effects of Dennettia tripetalla (Backer), Xylopia aethiopica (Dunal) and Aframomum melegueta Schum Oils against the African Sweet Potato Weevil, Cylas puncticollis (Boheman)
Authors: Nta A. I. , Oku E. E. 
Published: December 2019

Laboratory investigations were performed to ascertain the efficacies of Dennettia tripetalla (G.Backer), Xylopiaa ethiopica (A. Rich) and Aframomum melegueta (K. Schum) for the control of Cylas puncticolis, African sweet potato weevil. Organic solvent extracts of the leaves and fruits of the test plants were separately applied at concentration of 1, 3 and 5% (w/v) for investigation. The biological assays were conducted for six months under ambient temperature, relative humidity (28±3°C, 65±5% RH) and 12Hr light/dark photoperiods; laid out in a completely randomized design with each treatment replicated four times. Results disclosed that 3 and 5% extracts of the three test plants led to significantly (P<0.05) higher mortality of C. puncticollis when compared with 1% and control. 3.75 extract of the tubers. n-hexane extracts of all the test plant products significantly (P <0.05) repelled more than 60% of C. puncticollis within one-hour of exposure. . Extracts of A. melegueta fruit at 3 and 5% and X. aethiopica fruit at 5% had the most significant (P<0.05) insecticidal activity, followed by extract of D. tripetalla (at 5%). Adult emergence was also significantly higher in control than treated tubers with A. melegueta products giving the lowest significant number of emerged adults. The results of this research demonstrate the efficacies of the test plants extracts for the control of C. puncticollis infesting sweet potato roots during post-harvest storage at the small scale farming level in Calabar, Nigeria.
SNX16 activates c‐Myc signaling by inhibiting ubiquitin‐mediated proteasomal degradation of eEF1A2 in colorectal cancer development
Authors: Shen Zhiyong , Li Yongsheng , Fang Yuan , Lin Mingdao , Feng Xiaochuang , Li Zhenkang , Zhan Yizhi , Liu Yuechen , Mou Tingyu , Lan Xiaoliang , Wang Yanan , Li Guoxin , Wang Jiping , Deng Haijun 
Published: December 2019

Sorting nexin 16 (SNX16), a member of the sorting nexin family, has been implicated in tumor development. However, the function of SNX16 has not yet been investigated in colorectal cancer (CRC). Here, we showed that SNX16 expression was significantly upregulated in CRC tissues compared with normal counterparts. Upregulated mRNA levels of SNX16 predicted poor survival of CRC patients. Functional experiments showed that SNX16 could promote CRC cells growth both in vitro and in vivo. Knockdown of SNX16 induced cell cycle arrest and apoptosis, whereas ectopic overexpression of SNX16 had the opposite effects. Mechanistically, SNX16‐eukaryotic translation elongation factor 1A2 (eEF1A2) interaction could inhibit the degradation and ubiquitination of eEF1A2, followed by activation of downstream c‐Myc signaling. Our study unveiled that the SNX16/eEF1A2/c‐Myc signaling axis could promote colorectal tumorigenesis and SNX16 might potentially serve as a novel biomarker for the diagnosis and an intervention of CRC.
Rigidity evaluation of pre‐stressed rubber bearings of long‐span roofs
Authors: Morita Akira , Honma Keiichi , Watanabe Yasuhiro , Nakamura Misaki , Yamashita Tetsuo 
Published: December 2019

AbstractWhen The Great East Japan Earthquake of 2011 occurred, long‐span structures such as gymnasium with long‐span steel ceiling supported by RC columns was damaged as the bearings, which connected the steel roof column and the RC columns, were damaged. In this study, two effective improvements to prevent the pull‐out of anchor bolts and crushing of base mortar are proposed. The first improvement is to add disk springs between the base plate and anchor bolt nuts, which prevents the pull‐out of anchor bolts. In the second improvement, an elastic rubber plate is inserted between the base plate and mortar to avoid mortar crushing. Based on test results, an evaluation method for rotational stiffness is proposed, which can be calculated from the stiffness corresponding to the pre‐stressed force, disk spring, anchor bolts, and rotational spring constant of the rubber.
Electrical impedance myography for reducing sample size in Duchenne muscular dystrophy trials
Authors: Leitner Melanie L. , Kapur Kush , Darras Basil T. , Yang Michele , Wong Brenda , Dalle Pazze Laura , Florence Julaine , Buck Martin , Freedman Laura , Bohorquez Jose , Rutkove Seward , Zaidman Craig 
Published: December 2019

AbstractObjectiveTo evaluate the sensitivity of electrical impedance myography (EIM) to disease progression in both ambulatory and non‐ambulatory boys with DMD.Methods and ParticipantsA non‐blinded, longitudinal cohort study of 29 ambulatory and 15 non‐ambulatory boys with DMD and age‐similar healthy boys. Subjects were followed for up to 1 year and assessed using the Myolex® mViewTM EIM system as part of a multicenter study.ResultsIn the ambulatory group, EIM 100 kHz resistance values showed significant change compared to the healthy boys. For example, in lower extremity muscles, the average change in EIM 100 kHz resistance values over 12 months led to an estimated effect size of 1.58. Based on these results, 26 DMD patients/arm would be needed for a 12‐month clinical trial assuming a 50% treatment effect. In non‐ambulatory boys, EIM changes were greater in upper limb muscles. For example, biceps at 100kHz resistance gave an estimated effect size of 1.92 at 12 months. Based on these results, 18 non‐ambulatory DMD patients/arm would be needed for a 12‐month clinical trial assuming a 50% treatment effect. Longitudinal changes in the 100 kHz resistance values for the ambulatory boys correlated with the longitudinal changes in the timed supine‐to‐stand test. EIM was well‐tolerated throughout the study.InterpretationThis study supports that EIM 100 kHz resistance is sensitive to DMD progression in both ambulatory and non‐ambulatory boys. Given the technology’s ease of use and broad age range of utility it should be employed as an exploratory endpoint in future clinical therapeutic trials in DMD.Trial Registration: Clincialtrials.gov registration #NCT02340923
Predefined containment control for general linear multiagent systems with time‐varying delays and switching topologies
Authors: Zhou Shiyu , Hua Yongzhao , Dong Xiwang , Li Qingdong , Ren Zhang 
Published: December 2019

AbstractContainment control problems for general linear multiagent systems with switching interaction topologies and time‐varying delays are studied. Firstly, state observers are constructed to estimate the multiple leaders under the influence of switching graphs and time‐varying delays. Secondly, a predefined containment protocol is presented based on the distributed state observer, where the expected convex combination of multiple leaders is predefined by several given weights. Moreover, an algorithm with two steps to confirm the gain matrices of the containment protocol and state observer is given. Based on linear matrix inequality technique and common Lyapunov‐Krasovskii stability theory, the convergence of this control strategy for multiagent systems with switching topologies and time‐varying delays to achieve state containment is proved. Finally, a numerical simulation is given to verify the validity of the theoretical results.
Growth charts in Kabuki syndrome 1
Authors: Ruault Valentin , Corsini Carole , Duflos Claire , Akouete Sandrine , Georgescu Véra , Abaji Mario , Alembick Yves , Alix Eudeline , Amiel Jeanne , Amouroux Cyril , Barat‐Houari Mouna , Baumann Clarisse , Bonnard Adeline , Boursier Guilaine , Boute Odile , Burglen Lydie , Busa Tiffany , Cordier Marie‐Pierre , Cormier‐Daire Valérie , Delrue Marie‐Ange , Doray Bérénice , Faivre Laurence , Fradin Mélanie , Gilbert‐Dussardier Brigitte , Giuliano Fabienne , Goldenberg Alice , Gorokhova Svetlana , Héron Delphine , Isidor Bertrand , Jacquemont Marie‐Line , Jacquette Aurélia , Jeandel Claire , Lacombe Didier , Le Merrer Martine , Sang Kim Hanh Le Quan , Lyonnet Stanislas , Manouvrier Sylvie , Michot Caroline , Moncla Anne , Moutton Sébastien , Odent Sylvie , Pelet Anna , Philip Nicole , Pinson Lucile , Reversat Julie , Roume Joëlle , Sanchez Elodie , Sanlaville Damien , Sarda Pierre , Schaefer Elise , Till Marianne , Touitou Isabelle , Toutain Annick , Willems Marjolaine , Gatinois Vincent , Geneviève David 
Published: December 2019

AbstractKabuki syndrome (KS, KS1: OMIM 147920 and KS2: OMIM 300867) is caused by pathogenic variations in KMT2D or KDM6A. KS is characterized by multiple congenital anomalies and neurodevelopmental disorders. Growth restriction is frequently reported. Here we aimed to create specific growth charts for individuals with KS1, identify parameters used for size prognosis and investigate the impact of growth hormone therapy on adult height. Growth parameters and parental size were obtained for 95 KS1 individuals (41 females). Growth charts for height, weight, body mass index (BMI) and occipitofrontal circumference were generated in standard deviation values for the first time in KS1. Statural growth of KS1 individuals was compared to parental target size. According to the charts, height, weight, BMI, and occipitofrontal circumference were lower for KS1 individuals than the normative French population. For males and females, the mean growth of KS1 individuals was −2 and −1.8 SD of their parental target size, respectively. Growth hormone therapy did not increase size beyond the predicted size. This study, from the largest cohort available, proposes growth charts for widespread use in the management of KS1, especially for size prognosis and screening of other diseases responsible for growth impairment beyond a calculated specific target size.
A Renal‐Clearable Macromolecular Reporter for Near‐Infrared Fluorescence Imaging of Bladder Cancer
Authors: Huang Jiaguo , Jiang Yuyan , Li Jingchao , He Shasha , Huang Jingsheng , Pu Kanyi 
Published: December 2019

AbstractBladder cancer (BC) is a prevalent disease with high morbidity and mortality; however, in vivo optical imaging of BC remains challenging because of the lack of cancer‐specific optical agents with high renal clearance. Herein, a macromolecular reporter (CyP1) was synthesized for real‐time near‐infrared fluorescence (NIRF) imaging and urinalysis of BC in living mice. Because of the high renal clearance (ca. 94 % of the injection dosage at 24 h post‐injection) and its cancer biomarker (APN=aminopeptidase N) specificity, CyP1 can be efficiently transported to the bladder and specially turn on its NIRF signal to report the detection of BC in living mice. Moreover, CyP1 can be used for optical urinalysis, permitting the ex vivo tracking of tumor progression for therapeutic evaluation and easy translation of CyP2 as an in vitro diagnostic assay. This study not only provides new opportunities for non‐invasive diagnosis of BC, but also reveals useful guidelines for the development of molecular reporters for the detection of bladder diseases.
Effects of halloysite nanotubes on the morphology and CO2/CH4 separation performance of Pebax/polyetherimide thin‐film composite membranes
Authors: Afshoun Hamid Reza , Pourafshari Chenar Mahdi , Moradi Mohammad Reza , Ismail Ahmad Fauzi , Matsuura Takeshi 
Published: December 2019

ABSTRACTEnhancing the performance of gas separation membranes is one of the major concerns of membrane researchers. Thus, in this study, poly(ether‐block‐amide) (Pebax)/polyetherimide (PEI) thin‐film composite membranes were prepared and their CO2/CH4 gas separation performance was investigated by means of pure and mixed gases permeation tests. To improve the properties of these membranes, halloysite nanotubes (HNT) were added to Pebax layer at different loadings of 0.5, 1, 2, and 5 wt % to form Pebax‐HNT/PEI membranes. Scanning electron microscopy, gas sorption, X‐ray diffraction, Fourier‐transform infrared, and differential scanning calorimetry tests were also performed to investigate the impact of HNT on structure and properties of prepared membranes. Results showed that both CO2/CH4 selectivity and CO2 permeance increased by adding HNT to Pebax layer up to 2 wt %. By increasing HNT loading to 5 wt %, the CO2/CH4 selectivity decreased from 32 to 18, while CO2 permeance increased from 3.25 to 4.2 GPU. Pebax/PEI and Pebax‐HNT/PEI membranes containing 2 wt % of HNT were tested using CO2/CH4 gas mixtures at different feed CO2 concentrations and feed pressure of 4 bar. The results showed that with increasing CO2 concentration from 20 to 80 vol %, CO2/CH4 selectivity of Pebax/PEI composite membranes increased by 19%, while, in Pebax‐HNT/PEI membrane, CO2/CH4 selectivity decreased by 40%. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48860.
Plasticization of poly(lactide) with poly(ethylene glycol): Low weight plasticizer vs triblock copolymers. Effect on free volume and barrier properties
Authors: Chaos Ana , Sangroniz Ainara , Fernández Jorge , del Río Javier , Iriarte Marian , Sarasua Jose Ramon , Etxeberria Agustin 
Published: December 2019

ABSTRACTIn order to make poly(lactide) (PLA) suitable for food packaging applications, its toughness must be improved. In this work, the plasticization effectiveness of a low‐molecular‐weight plasticizer and a triblock copolymer are analyzed. For this purpose, PLA is blended with poly(ethylene glycol) (PEG) and poly(lactide‐ethylene glycol‐lactide) (LA‐EG‐LA) triblock copolymer. The obtained results show that copolymers are more effective, reducing the glass transition temperature of PLA. Although PLA/PEG blends have been widely studied in the literature, the barrier character has not been analyzed, which is of paramount importance for packaging applications. Therefore, the permeability to carbon dioxide, oxygen, and water vapor of PLA/PEG blends has been characterized observing an increase with the incorporation of PEG, which is the expected behavior. However, the incorporation of LA‐EG‐LA copolymers leads to permeability values that are slightly higher, similar, or even lower than PLA. Furthermore, the free volume of the samples has been analyzed in order to gain a deeper insight on the factors affecting the transport properties. Overall, this works aims to provide a better understanding towards the design of biodegradable packaging with improved properties that could be also extended to other biodegradable polymers. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48868.
Eroding diversity away: Impacts of a tetrapod breakwater on a subtropical coral reef
Authors: Masucci Giovanni Diego , Acierno Alessandro , Reimer James Davis 
Published: December 2019

Abstract

Artificial barriers for coastal protection have been deployed across numerous tropical and subtropical islands in the Pacific, including Okinawa Island, southern Japan, where artificial defences have been installed along a large part of the coastline.
Although artificial barriers can lead to beach narrowing or loss and can exacerbate erosion, their effects on coral reef ecosystems remain understudied.
This study investigated the impact of a tetrapod breakwater in Ogimi Village, Okinawa Island, Japan, comparing the area affected by the presence of the barrier with a nearby natural coastline, and examining differences in physical parameters (depth profiles, sediment granulometry, and erosion on plaster balls) and benthic community composition.
Significant differences in depth profiles, sediment granulometry, and erosion were found, suggestive of alterations in water energy levels (lower than controls on the landward side of the barrier, and higher on the seaward side).
The benthic community was also clearly affected, with almost no living corals growing over the blocks or in their proximity.
Overall, the data show how breakwaters can affect the physical environment and benthic communities in a subtropical coral reef ecosystem, with negative consequences for coral survival.
Determining spatial use of the world's second largest humpback dolphin population: Implications for place‐based conservation and management
Authors: Liu Mingming , Bejder Lars , Lin Mingli , Zhang Peijun , Dong Lijun , Li Songhai 
Published: December 2019

AbstractPlace‐based management can be an effective conservation tool to protect cetaceans from anthropogenic pressures. The spatial use of the world's second largest population of the threatened Indo‐Pacific humpback dolphins (Sousa chinensis) is not well‐documented, which makes it challenging to designate protected areas for this population.To address this knowledge gap and to test the efficacy of an existing dolphin protected area (Zhanjiang Leizhou Bay Municipal Humpback Dolphin Nature Reserve, ZLBMHDNR), boat‐based surveys were conducted to document dolphin occurrence from 2015 to 2018, covering an area of 1221 km2in the eastern waters off Zhanjiang, China. In total, 253 dolphin group sightings were obtained during 174 survey days.Spatial analysis showed that humpback dolphins aggregated in threecore‐use areaswith higher sighting density within the survey area. Furthermore,intermediate‐useandbroad‐use areaswere identified that could be essential for the movements of humpback dolphins among thesecore‐use areas.The spatial usage of humpback dolphins was compared inside and outside the ZLBMHDNR. Results suggest that the ZLBMHDNR is insufficient to encompass a significant portion of dolphin habitat. The ZLBMHDNR (21 km2) is not large enough, and thus it should be expanded for effective place‐based conservation management in this region.For developing a protected area network, important dolphin habitats identified in this study should be protected as a single management unit. Additionally, mitigation of anthropogenic pressures is needed to be taken into consideration as conservation initiatives in the study area.This study provides support for a more science‐informed protected area network, and highlights the necessity of implementing place‐based conservation and management for the world's second largest humpback dolphin population.
Generation of Distinct Patterns of Rheumatoid Arthritis Autoantigens by Peptidylarginine Deiminase Types 2 and 4 During Perforin‐Induced Cell Damage
Authors: Romero Violeta , Darrah Erika , Andrade Felipe 
Published: December 2019

ObjectiveTo address the independent roles of peptidylarginine deiminase type 2 (PAD2) and PAD4 in generating rheumatoid arthritis (RA) autoantigens by using a system that mimics intracellular citrullination in the RA joint.MethodsPAD2‐ or PAD4‐expressing 293T cells and mock‐transfected cells were used as targets in cytotoxic assays using lymphokine‐activated killer cells, cytotoxic YT cell granule contents, or purified human perforin. Protein citrullination and autoantigen production were determined by immunoblotting using the anti–modified citrulline–Senshu method and RA sera (n = 30), respectively.ResultsRA sera recognized at least 3 categories of autoantigens in PAD‐expressing target cells killed by the cytotoxic lymphocyte granule–induced death pathway. These included: 1) autoantigens targeted in their native form, 2) citrullinated antigens, and 3) antigens cleaved by cytotoxic proteases (e.g., granzymes). Interestingly, although target cells expressing PAD2 or PAD4 showed prominent hypercitrullination of a broad range of proteins during cytotoxic granule–induced cell damage, autoantibodies in RA sera targeted only a very limited number of antigens in hypercitrullinated cells. Furthermore, RA sera showed distinct reactivities to autoantigens generated by PAD2 or PAD4.ConclusionThe cytotoxic granule–induced death pathway has the capacity to modify antigens by inducing hypercitrullination and antigen cleavage in target cells. Interestingly, among a large number of citrullinated proteins generated by PAD2 and PAD4 in cells, only a few are likely involved in the production of autoantibodies in RA.
Robust tracking control of an aircraft with critical actuator jam failures
Authors: Chan Po‐Chun , Chang Bor‐Chin , Bayram Mevlut , Kwatny Harry , Belcastro Christine M. 
Published: December 2019

AbstractIn this paper, we present a new single fixed controller approach based on the multivariableH2control/regulator theory with internal model principle to solve a challenging control problem arising from an on‐flight critical elevator jam at random positions that otherwise would need switching numerous controllers or online adaptive redesign approaches.
Synthesis and activity of a coumarin‐based fluorescent probe for hydroxyl radical detection
Authors: Zhang Bin , Xu Lijing , Zhou Yindi , Zhang Weijian , Wang Yuanhong , Zhu Yu 
Published: December 2019

AbstractAs a type of reactive oxygen species (ROS), hydroxyl radical (·OH) is closely associated with many kinds of diseases. The present study aimed to develo p a novel OH fluorescent probe based on coumarin, a new compound that has not been previously reported. This probe exhibited good linear range and selectivity for ·OHl, and is able to avoid interference from some metal ions and other kinds of ROS (H2O2, O2.‐, 1O2, and HClO). Meanwhile, this probe has been used to evaluate the ·OH‐scavenging efficiency of different compounds, such as isopropyl alcohol, cytosine, uracil, Tempo, Glutathione (GSH), and dimethyl sulfoxide (DMSO). Therefore, the present study shows that this probe not only can effectively measure the level of ·OH, but also can assess the ·OH‐scavenging efficiency of different compounds. Furthermore this current study suggested that following further optimization, this probe may be potentially applied in the diagnosis of oxidative stress in human body.