bluuebunny/crossref_metadata_2025_split huggingface dataset:
Newcomers and Locals. Invisible Boundaries Among Inhabitants of the Divided City in the Balkans
Authors: Maciulewicz Marzena Anna 
Published: December 2019

Newcomers and Locals. Invisible Boundaries Among Inhabitants of the Divided City in the BalkansResearch on divided cities in the Balkans focuses mostly on ethnic/national divisions. Is this perspective, however, truly viable and sufficient for the description of post-conflict cities in the Balkans? The question is posed not only because of the fact that every city is somehow divided or fragmented. More noteworthy, and not widely known, is the fact that the unstable structure of a city’s population is much more complex with its intergroup relations becoming much more complicated – a fact commonly disregarded due to the importance assigned to ethnic/national rifts which have dominated the narrative of the divided city. Underestimating the importance of other relations within society and the dynamics of a highly changeable social structure, one cannot uncover the actual nature of intergroup relations in a divided city.The main objective of this paper is to briefly present the state of contemporary inter- and intragroup relations in a divided city, with a special focus on inhabitants’ residential status. The article is based mainly on the case study of Mitrovica supplemented with references to other cities in the Balkans considered as divided. The paper is based on selected outcomes of qualitative and quantitative field research conducted in Mitrovica in 2017 and 2018 as well as results of other studies devoted mostly to Mitrovica but also to Mostar, Vukovar, Skopje and Sarajevo. Przybysze i miejscowi. Niewidoczne granice wśród mieszkańców podzielonego miasta na BałkanachBadania nad podzielonymi miastami na Bałkanach koncentrują się głównie na podziałach etnicznych/narodowych. Jednak, czy ta perspektywa jest odpowiednia i wystarczająca do opisania miast pokonfliktowych na Bałkanach? To pytanie nie wynika tylko z faktu, że każde miasto jest w jakiś sposób podzielone lub rozdrobnione. Bardziej istotny, a jednocześnie mniej znany jest fakt, że niestabilna struktura populacji tych miast jest znacznie bardziej złożona, a relacje międzygrupowe – znacznie bardziej skomplikowane, niż przedstawiają to dominujące narracje o podzielonych miastach przypisujące kluczowe znaczenie rozłamom etnicznym/narodowym. Tymczasem, nie doceniając znaczenia innego rodzaju relacji w społeczeństwie oraz dynamiki wysoce zmiennej struktury społecznej, nie można odkryć rzeczywistej natury relacji międzygrupowych w podzielonym mieście.Głównym celem artykułu jest przedstawienie współczesnego stanu między- i wewnątrzgrupowych relacji w podzielonym mieście, ze szczególnym uwzględnieniem statusu mieszkańców Mitrowicy. Artykuł jest przede wszystkim studium przypadku miasta Mitrowica (Kosowo) uzupełnionym o odniesienia do innych podzielonych miast na Bałkanach. Artykuł opiera się na wybranych wynikach jakościowych i ilościowych badań terenowych przeprowadzonych w Mitrowicy w 2017 i 2018 roku, jak również na wynikach innych badań poświęconych głównie Mitrowicy, ale także Mostarowi, Vukovarowi, Skopje i Sarajewu.
The Seasonal Cycle of Upper-Ocean Mixing at 8°N in the Bay of Bengal
Authors: Cherian D. A. , Shroyer E. L. , Wijesekera H. W. , Moum J. N. 
Published: December 2019

AbstractWe describe the seasonal cycle of mixing in the top 30–100 m of the Bay of Bengal as observed by moored mixing meters (χpods) deployed along 8°N between 85.5° and 88.5°E in 2014 and 2015. All χpod observations were combined to form seasonal-mean vertical profiles of turbulence diffusivity KT in the top 100 m. The strongest turbulence is observed during the southwest and postmonsoon seasons, that is, between July and November. The northeast monsoon (December–February) is a period of similarly high mean KT but an order of magnitude lower median KT, a sign of energetic episodic mixing events forced by near-inertial shear events. The months of March and April, a period of weak wind forcing and low near-inertial shear amplitude, are characterized by near-molecular values of KT in the thermocline for weeks at a time. Strong mixing events coincide with the passage of surface-forced downward-propagating near-inertial waves and with the presence of enhanced low-frequency shear associated with the Summer Monsoon Current and other mesoscale features between July and October. This seasonal cycle of mixing is consequential. We find that monthly averaged turbulent transport of salt out of the salty Arabian Sea water between August and January is significant relative to local E − P. The magnitude of this salt flux is approximately that required to close model-based salt budgets for the upper Bay of Bengal.
Does Using Multiple Computer Monitors for Office Tasks Affect User Experience?
Authors: Gallagher Kaitlin M. , Cameron Laura , De Carvalho Diana , Boulé Madison 
Published: December 2019

Objective To compare the impact of multiple computer monitor configurations on health and performance outcomes compared to the use of a single monitor. Background Multiple monitor configurations are used in office settings to promote increased productivity by providing more screen space; however, it is unknown if there are health-related trade-offs to increased productivity. Method A systematic review was conducted according to the PRISMA statement guidelines and adapted the best evidence synthesis. Results Eighteen studies were included in our review. There was strong evidence that implementing dual monitors is in line with users’ preference. There was also moderate evidence for controlled laboratory studies demonstrating that multiple monitors may increase task efficiency with decreased desktop interaction; however, implementing multiple monitors may also result in nonneutral neck postures for users. Conclusion More research needs to be conducted on biomechanical exposures when using larger displays. Longitudinal field studies should be conducted to determine the influence of monitor interventions on health, productivity, and well-being. All studies must consider task complexity and user positioning and should measure health and productivity outcomes together. Researchers must also consider up-to-date purchasing trends when choosing the monitor configurations and sizes for their studies. Application Regulatory bodies and practitioners can use the results to develop evidence-based monitor guidelines and inform decision-making in practice, respectively. Researchers can use this information to design future studies on monitor configurations that incorporate current purchasing trends.
Student nurses’ views of right to food of older adults in care homes
Authors: Dogan Elisabeth Irene Karlsen , Raustøl Anne , Terragni Laura 
Published: December 2019

Background: Human rights are an important part of nursing practice. Although there is increasing recognition regarding the importance of including human rights education in nursing education, few studies have focused on nursing students’ perspectives and experiences in relation to human rights in nursing, especially regarding older nursing home residents’ right to food. Objective: To explore nursing students’ perspectives and experiences in relation to the right to food. Research design: The study followed a qualitative interpretative research design. Data were collected from multistage focus groups before, during and after clinical placement in a nursing home and analysed through thematic analysis. Participants and research context: Participants were 18 first-year nursing students; the study was conducted in 2017. Ethical considerations: This study was approved by the Norwegian Centre for Research Data. Findings: Students’ understanding of older nursing home residents’ right to food was a dynamic process. Their perceptions evolved from a polarized perspective to a reality orientation and finally to retrospective reflection. Discussion: The article discusses how nursing students learn about and understand human rights within and throughout their placements. Conclusion: The study bridges human rights theory and practice. Findings suggest that the human right to food must be enacted in daily practice for students to learn in context. Human rights education, specifically pertaining to nutritional care, thus benefits from a practice-oriented approach preparing students to face ‘real life’ challenges and ethical dilemmas. Findings will help nurse educators tailor education in this field.
Differences between preschool children using tablets and non-tablets in visual perception and fine motor skills
Authors: Lin Ling-Yi 
Published: December 2019

Background Numerous touch-screen applications designed to support visual perceptual skills and fine motor development for young children are available. Objectives This study aimed to investigate whether or not there were differences between children using tablets and non-tablets in visual perception and fine motor skills and to examine the association between visual perception and fine motor skills in two groups. Methods This study had tablet and non-tablet groups, each with 36 typically developing preschool children. Results Children in the non-tablet group yielded significantly higher scores in the subtests of visual discrimination, visual memory, spatial relationships, form constancy, visual figure ground, fine motor precision, fine motor integration, and manual dexterity than those in the tablet group. The association between visual perception and fine motor skills demonstrated different patterns in the two groups. Conclusion There are differences in visual perception and fine motor skills between children using tablets and non-using tablets. Different patterns of association relationship support the need for occupational therapists to consider the underlying mechanism.
Asian Paints: Towards a Lustrous HR Future
Authors: Jaiswal Akanksha , Pande Richa , Deshpande Kirti , S. Sabhanathan 
Published: December 2019

The case narrates the story of Asian Paints, an Indian organization operating in the paint industry. Although best practices were an integral part of Asian Paints from its inception, a shared language for all people decisions and processes was felt necessitated. The objective of this case is to highlight Asian Paints management’s need to professionalize the human resource (HR) processes and practices and strategize towards building the leadership pipeline. The case describes Asian Paints’ leadership competency framework (LCF) and examines its purpose of becoming a common language across all HR processes in the organization. This LCF not only addressed the existing business exigencies but also imbibed the culture on which Asian Paints was fabricated, thus, providing shared principles for all employee-related processes. Key people practices at Asian Paints are encapsulated in the competency framework which not only guides its own leaders but also serves as a benchmark for other organizations.
Computational analysis of continuous body temperature provides early discrimination of graft-versus-host disease in mice
Authors: He Kuang , Wu Zhenke , Fujiwara Hideaki , Whitesall Steven , Zajac Cynthia K. , Choi Sung Won , Reddy Pavan , Tewari Muneesh 
Published: December 2019

Key PointsUnsupervised machine learning analysis of continuous body temperature data revealed early signals of aGVHD in allo-HCT mice. Continuous measurement of body temperature is promising for early prediction of aGVHD in human allo-HCT patients.
End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain
Authors: Farrell Ann T. , Panepinto Julie , Carroll C. Patrick , Darbari Deepika S. , Desai Ankit A. , King Allison A. , Adams Robert J. , Barber Tabitha D. , Brandow Amanda M. , DeBaun Michael R. , Donahue Manus J. , Gupta Kalpna , Hankins Jane S. , Kameka Michelle , Kirkham Fenella J. , Luksenburg Harvey , Miller Shirley , Oneal Patricia Ann , Rees David C. , Setse Rosanna , Sheehan Vivien A. , Strouse John , Stucky Cheryl L. , Werner Ellen M. , Wood John C. , Zempsky William T. 
Published: December 2019

AbstractTo address the global burden of sickle cell disease (SCD) and the need for novel therapies, the American Society of Hematology partnered with the US Food and Drug Administration to engage the work of 7 panels of clinicians, investigators, and patients to develop consensus recommendations for clinical trial end points. The panels conducted their work through literature reviews, assessment of available evidence, and expert judgment focusing on end points related to: patient-reported outcomes (PROs), pain (non-PROs), the brain, end-organ considerations, biomarkers, measurement of cure, and low-resource settings. This article presents the findings and recommendations of the PROs, pain, and brain panels, as well as relevant findings and recommendations from the biomarkers panel. The panels identify end points, where there were supporting data, to use in clinical trials of SCD. In addition, the panels discuss where further research is needed to support the development and validation of additional clinical trial end points.
Clonal evolution and immune evasion in posttransplantation relapses
Authors: Vago Luca 
Published: December 2019

Abstract
Despite the considerable improvements witnessed over the last few decades in the feasibility and safety of allogeneic hematopoietic cell transplantation (allo-HCT) for hematological malignancies, disease relapse continues to represent a frequent occurrence, with largely unsatisfactory salvage options. Recent studies have shed new light on the biology of posttransplantation relapses, demonstrating that they can frequently be explained using an evolutionary perspective: The changes in disease clonal structure and immunogenicity that are often documented at relapse may in fact represent the end results of a process of selection, allowing the outgrowth of variants that are more capable of resisting the therapeutic control of allo-HCT. This review provides an overview of the mechanisms forming the basis of relapse, including clonal evolution, gain of tropism for privileged sites, genomic and nongenomic changes in the HLA asset, and enforcement of immune checkpoints. Finally, this review discusses how these mechanisms may combine in complex patterns and how understanding and untangling these interactions may provide key knowledge for the selection of personalized therapeutic approaches.
Navigating the nexus of MRD and novel agents in ALL
Authors: Advani Anjali S. , Copelan Edward A. 
Published: December 2019

AbstractThe landscape of acute lymphoblastic leukemia (ALL) has evolved significantly over the last few years. Identification of specific recurrent genetic alterations and of minimal residual disease (MRD) guides prognostic classification and management. Novel agents (eg, blinatumomab) have demonstrated encouraging results in relapsed/refractory (R/R) and MRD+ patients and are currently incorporated into upfront treatment in specific settings. Other new strategies include the incorporation of tyrosine kinase inhibitor-based therapy for patients with Philadelphia chromosome–like ALL and the use of DOT inhibitors and bcl-2/bcl-xl inhibitors in R/R disease. These innovations promise to improve management and outcome in this disease.
Molecular profiling and management of mantle cell lymphoma
Authors: Ruan Jia 
Published: December 2019

Abstract
Mantle cell lymphoma (MCL) is a distinct subtype of B-cell non-Hodgkin lymphoma characterized by the t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression and cell cycle dysregulation. Molecular profiling with gene expression and deep sequencing analyses has identified genomic and epigenomic alterations in pathways regulating the cell cycle, DNA damage response, proliferation, and survival, which contribute to disease progression with important prognostic and therapeutic implications. Clinically, the nonnodal MCL subset is notable for leukemic presentation, indolent behavior, and association with hypermutated IGHV and lack of SOX11 expression, which differentiates it from the conventional nodal MCL. In addition to the Mantle Cell Lymphoma International Prognostic Index score and proliferative gene signatures, 17p/TP53 and 9p/CDKN2A alterations, and genomic complexity have emerged as clinically useful biomarkers of high-risk disease associated with aggressive disease behavior, resistance to chemotherapy, and poor overall survival. Although intensive chemoimmunotherapy regimens that incorporate high-dose cytarabine and stem cell transplantation have improved survival in young and fit MCL patients, the introduction of Bruton tyrosine kinase inhibitors and other novel agents has made effective outpatient-based treatment accessible to nearly all MCL patients. Optimizing combinations of novel agents in the relapsed setting and moving novel agents to the first-line setting have the potential to fundamentally change the MCL therapeutic landscape for the better, especially for patients ineligible for chemotherapy or those with high-risk mutations that are resistant to chemotherapy.
Emerging strategies in peripheral T-cell lymphoma
Authors: Mehta-Shah Neha 
Published: December 2019

Abstract
Peripheral T-cell lymphomas (PTCLs) are a heterogenous group of aggressive non-Hodgkin lymphomas that are less chemosensitive than their B-cell counterparts. Until recently, standard therapy did not distinguish between subtypes, and deeper understanding of the biology of these diseases was lacking. The availability of targeted therapy and more sophisticated subtype classification has translated into the development of novel treatment options for these rare diseases. This includes the development of a brentuximab vedotin-based upfront chemotherapy regimen that confers an overall survival benefit for a subset of patients. Clinical trials of targeted agents, as well as development of better preclinical models of PTCL, are leading to therapeutic advances in the field, including the development of phosphoinositide-3-kinase inhibitors, histone deacetylase inhibitor-based strategies, CD30-directed strategies, Janus kinase inhibitors, and spleen-associated tyrosine kinase inhibitors. Better understanding of the biology of these diseases based on gene expression profiling, minimal residual disease evaluation, and modeling in patient-derived xenografts should help define mechanisms of response and resistance to therapy. Given the complex biology of these heterogeneous lymphomas, well-tolerated combination strategies targeted toward specific subtypes of PTCL can lead to advances in the field. Similar to the story of brentuximab vedotin, development of effective therapies in the salvage setting will likely lead to improved upfront strategies in PTCLs, and ultimately a more personalized approach.
How I treat a refractory myeloma patient who is not eligible for a clinical trial
Authors: Leng Siyang , Bhutani Divaya , Lentzsch Suzanne 
Published: December 2019

AbstractMyeloma patients not eligible for clinical trials have many treatment options. Choosing the next best therapy starts with careful assessment of the biology and dynamics of the disease at relapse, as well as the condition and situation of the patient. Fit patients should be considered for triplet regimens, whereas intermediate and frail patients warrant dose-reduced triplets or doublets. An indolent serologic relapse may be treated with dose intensification, especially in a maintenance situation, whereas a rapid relapse requires a more aggressive approach with drug class change or a second-generation immunomodulatory drug (IMID) or proteasome inhibitor (PI). Monoclonal antibodies, in combination with PIs and IMIDs, have proven highly efficacious in early and late relapse. Key elements of supportive care include infection prevention, bone health, thromboprophylaxis, and management of active symptoms, such as pain and distress.
What's new in the prevention and treatment of cancer-associated thrombosis?
Authors: Kimpton Miriam , Carrier Marc 
Published: December 2019

AbstractVenous thromboembolism (VTE) is a common complication in ambulatory cancer patients receiving chemotherapy. Current clinical guidelines recommend against the use of routine primary thromboprophylaxis in unselected ambulatory cancer patients. The Khorana score is a risk assessment tool derived and prospectively validated for the identification of cancer patients at high risk of thrombotic complications. Recently, 2 randomized, controlled trials have assessed the use of low-dose direct oral Xa inhibitors, apixaban and rivaroxaban, for the prevention of cancer-associated thrombosis in ambulatory patients at intermediate to high risk of VTE (Khorana score ≥2). Taken together, these trials have shown that low-dose direct oral Xa inhibitors reduce the risk of VTE in this patient population without a significant increase in major bleeding. These results should encourage clinicians to consider the use of primary thromboprophylaxis in ambulatory cancer patients at intermediate to high risk of VTE who do not have any apparent risk factors for bleeding. The direct oral Xa inhibitors have also been assessed in the acute management of cancer-associated thrombosis. Current evidence suggests that these drugs are a convenient, effective, and safe option for the management of acute VTE in many cancer patients. Low-molecular weight heparin, however, may continue to be the treatment of choice depending on the presence of bleeding risk factors, the type of cancer, drug-drug interactions, and patient preferences.
Update from the laboratory: mechanistic studies of pathways of cancer-associated venous thrombosis using mouse models
Authors: Hisada Yohei , Mackman Nigel 
Published: December 2019

Abstract
Cancer patients have an increased risk of venous thromboembolism (VTE). The rate of VTE varies with cancer type, with pancreatic cancer having one of the highest rates, suggesting that there are cancer type–specific mechanisms of VTE. Risk assessment scores, such as the Khorana score, have been developed to identify ambulatory cancer patients at high risk of VTE. However, the Khorana score performed poorly in discriminating pancreatic cancer patients at risk of VTE. Currently, thromboprophylaxis is not recommended for cancer outpatients. Recent clinical trials showed that factor Xa (FXa) inhibitors reduced VTE in high-risk cancer patients but also increased major bleeding. Understanding the mechanisms of cancer-associated thrombosis should lead to the development of safer antithrombotic drugs. Mouse models can be used to study the role of different prothrombotic pathways in cancer-associated thrombosis. Human and mouse studies support the notion that 2 prothrombotic pathways contribute to VTE in pancreatic cancer patients: tumor-derived, tissue factor–positive (TF+) extracellular vesicles (EVs), and neutrophils and neutrophil extracellular traps (NETs). In pancreatic cancer patients, elevated levels of plasma EVTF activity and citrullinated histone H3 (H3Cit), a NET biomarker, are independently associated with VTE. We observed increased levels of circulating tumor-derived TF+ EVs, neutrophils, cell-free DNA, and H3Cit in nude mice bearing human pancreatic tumors. Importantly, inhibition of tumor-derived human TF, depletion of neutrophils, or administration of DNAse I to degrade cell-free DNA (including NETs) reduced venous thrombosis in tumor-bearing mice. These studies demonstrate that tumor-derived TF+ EVs, neutrophils, and cell-free DNA contribute to venous thrombosis in a mouse model of pancreatic cancer.