bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Chondroitin Polymerizing Factor (CHPF) as Tumor Promotor in Cholangiocarcinoma through Regulating Cell Proliferation, Cell Apoptosis and Cell Migration
Authors: Duan Xiaohui , Yang Jianhui , Jiang Bo , Duan Wenbin , Wei Rongguang , Zhang Hui , Mao Xianhai 
Published: June 2020

Abstract
Background: Cholangiocarcinoma (CCA) is a variety of biliary epithelial tumors involving intrahepatic, perihilar and distal bile duct. It is the most common malignant bile duct tumor in the liver and the second most common primary liver cancer, whose molecular mechanism not fully understood. Specifically, the relationship between CCA and chondroitin polymerizing factor (CHPF) is still not clear.Methods: In this study, detection of clinical specimens was performed to preliminarily study the role of CHPF in cholangiocarcinoma. Cholangiocarcinoma cells with CHPF knockdown were constructed for in vitro study, which was also used in the construction of mice xenograft model for investigating the role of CHPF in the development of cholangiocarcinoma.Results: The results demonstrated that CHPF was significantly upregulated in cholangiocarcinoma tissues compared with normal tissues. High expression of CHPF was correlated with more advanced tumor grade. Moreover, knockdown of CHPF significantly inhibited cell proliferation, cell migration, promoted cell apoptosis and arrest cell cycle in G2 phase in vitro, as well as suppressed tumor growth in vivo.Conclusions: In conclusion, CHPF was identified as a tumor promotor in the development and metastasis of cholangiocarcinoma, which may provide a novel therapeutic target for the targeted therapy against cholangiocarcinoma.
Prevalence and Impact of Fibrinolytic Dysregulation in Patients with Acute Coronary Syndromes
Authors: Wan Huaibin , Wu Zhihao , Lie Zhenbang , Li Daqiang , Su Shaohui 
Published: June 2020

Abstract
Background：Dual antiplatelet therapy can reduce coronary thrombosis and improve the prognosis in patients with acute coronary syndrome (ACS). However, there was limited prognostic information about fibrinolytic dysregulation in patients with ACS. This study is aimed to evaluated the prevalence and impact of fibrinolytic dysregulation in patients with acute coronary syndrome (ACS).Methods：We retrospectively analyzed coagulation and fibrinolysis related indexes of ACS in hospitalized adults with rapid thrombelastography between May 2016 and December 2018. All of the follow-up visits were ended by December 2019. The primary outcome was the occurrence of major adverse cardiovascular events (MACEs), which included unstable angina pectoris, non-fatal myocardial infarction, non-fatal cerebral infarction, heart failure and all-cause death. Results：338 patients were finally included with an average age of 62.5 ± 12.8 years old, 273 (80.5%) were males, 137(40.5%) patients were with STEMI. Fibrinolysis shutdown and hyperfibrinolysis were observed among 163 (48.2%) and 76(22.5%) patients, respectively. During a total of 603.2 person·years of follow-up period, 77 MACEs occurred (22.8%). Multivariate Cox regression analysis indicated that age [HR: 1.031 95% CI: 1.007-1.056, P = 0.012] and LY30 [HR: 1.097, 95% CI: 1.013-1.188, P = 0.023] were independently correlated with the occurrence of MACEs. The hazard ratios pertaining to MACEs in patients with LY30＜0.8% and ＞3.0% compared with those in the physiologic range(LY30: 0.8-3.0%) were 2.275 [HR: 2.275, 95% CI: 1.241-1.241, P = 0.003] and 1.196 [HR: 1.196, 95% CI: 0.679-2.109,P=0.535], respectively.Conclusions: Fibrinolytic dysregulation is very common in selected patients with ACS, and hyperfibrinolysis (HF) (LY30 >3%) is associated with poor outcomes in patients with ACS
Climatic change and its relationship with human society in northern Japan since the mid-Holocene - Quantitative reconstruction of atmospheric and sea surface temperature -
Authors: Kawahata Hodaka , Hatta Yoshiki , Kajita Hiroto , Ota Yuki , Akihiro Yoshida , Nishina Kenji , Aono Tomoya , Habu Junko 
Published: June 2020

Abstract
For the prediction for future climate, it is required to enhance our understanding of the Holocene climatic change. By estimating paleo-temperature, we attempted to examine the relationship between climatic changes and human activities in northern Japan. The alkenone SSTs showed a variation of 8.7 °C (14.5 °C to 23.2 °C). Jomon people living around Funka Bay were more dependent on marine products than in Honshu due to cooler climatic conditions. There are two Hypsithermal environments at Funka Bay around 4.6 cal. kyr BP and 1.2 cal. kyr BP. Sea levels for the last 7 kyrs have been controlled mainly by local/regional tectonic vertical movement. Therefore, the highstand never always corresponded to Hypsithermal environments. More than one driving forcing, rather than one, may control climatic/environmental change. The 4.2ka event in northern Japan could be characterized by cooling by a few degrees by the combination of reduced ESAM and El Niño mode. Another notable cooling event occurred in 1.0-0.8 cal. kyr BP due to the La Niña condition and reduced solar activities, which means that the Japanese archipelago never experienced Medieval Warm Event: instead, there was a Medieval Cold Event in Japan. The Okhotsk culture in Hokkaido prospered only under the Hypsithermal condition during the 5 th - 9 th centuries and subsequently it declined and was incorporated into the Satsumon culture under the cooler environmental conditions. For the Yayoi-era (2.9 cal. kyr BP-) and the following periods, our results are consistent with the previous results from Hiroshima Bay, western Japan, that cold periods (6 th - 7 th century BC, 3 rd century BC, 6 th century AD, 10 th -12 h century AD and 16 th century AD) coincided with major shifts in social systems in Japan.
Surgical management of ulnar styloid fractures: comparison of fixation with anchor suture and tension band wire
Authors: Chen Alvin Chao-Yu , Lin Yi-Hsuan , Weng Chun-Jui , Cheng Chun-Ying 
Published: June 2020

Abstract
Background Limited reference is available regarding surgical management in symptomatic ulnar styloid fractures with small bony avulsion. The study goal is to report the surgical outcomes using anchor suture fixation with comparison to traditional tension band wire fixation.Methods We retrospectively reviewed the medical records in patients who underwent surgical repair for unilateral ulnar styloid fractures with distal radioulnar instability between 2004 and 2017. A total of 31 patients were enrolled including two kinds of fixation methods. Anchor suture fixation plus distal radioulnar joint pinning was performed in ten patients with tiny avulsion bony fragments (group A); tension band wire fixation was performed in 21 patients with big styloid fracture fragments (group B). Patient characteristics and 2-year treatment outcomes were compared between two groups based on Mayo Modified Wrist Score (MMWS), Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH), visual analog scale (VAS) and surgical complication. Descriptive statistics were used for calculation of key variables; a p-value of < 0.05 was considered statistically significant.Results Based on Gaulke classification, there were five subtypes in group A and three subtypes in group B. Incidence of concomitant distal radius fractures was significantly higher in group B; other patient characteristics including age, sex, injury side, and time to surgery showed no significant difference. Outcome assessment regarding MMWS, QuickDASH and VAS was comparable between two groups. Bone-related complications including nonunion, DRUJ subluxation and styloid resorption were analyzed; the difference was not significant. Incidence of implant-related complications including migration and secondary removal surgery was significantly higher in group B (p = 0.021).Conclusion Surgical fixation in symptomatic ulnar styloid fractures yields comparable treatment outcomes in both fracture patterns. Implant-related complication with secondary removal surgery is more common in tension band wire group. Anchor suture fixation is a feasible option for tiny styloid avulsion fragments with limited surgical complication.
Probiotics Ameliorate Pioglitazone-associated Bone Loss in Diabetic Rats
Authors: Gholami Ahmad , Dabbaghmanesh Mohammad Hossein , Ghasemi Younes , Talezadeh Pedram , Koohpeyma Farhad , Montazeri-Najafabady Nima 
Published: June 2020

Abstract
Background: Pioglitazone as a PPAR-g agonist are used for management of type 2 diabetes mellitus. Nevertheless, evidence showed that the therapeutic modulation of PPARg activity using Pioglitazone may be linked with bone mass reduction and fracture risk in type 2 diabetes mellitus patients. The objective of the current research was to inspect the preventive role of some types of probiotic strains including (Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus casei, Bifidiobacterum longum and Bacillus coagulans) against pioglitazone-induced bone loss.Methods: Streptozotocin (60 mg/kg) was administered for diabetes induction. Diabetic rats were fed orally with pioglitazone (300 mg/kg) and probiotics (1×109 CFU/ml/day) alone and in combination of both for 4 weeks. Dual energy X-ray absorptiometry (DEXA) were used to asses BMD, BMC and area of the femur, spine and tibia at the experiment termination. Serum glucose, serum calcium, alkaline phosphatase, phosphorus, BUN, Creatinine, and urine calcium were also analyzed. Results: Administration of pioglitazone and probiotics alone and in combination significantly improved elevated blood glucose. Pioglitazone treatment significantly increased urinary calcium and BUN, and decreased ALP and creatinine. Co-treatment of probiotics with pioglitazone significantly decreased urinary calcium, creatinine and ALP. Pioglitazone showed detrimental effects on femur-BMD whereas treatment with probiotics remarkably ameliorated these effects. Among the tested probiotics Bifidiobacterum longum displayed the best protective effects on pioglitazone-induced bone loss in diabetic rats.Conclusion:This study suggests probiotic supplementation in diabetic patients on pioglitazone regime could be considering as a good strategy to ameliorate bone loss induced by pioglitazone.
FusAtNet: Dual Attention based SpectroSpatial Multimodal Fusion Network for Hyperspectral and LiDAR Classification
Authors: Mohla Satyam , Pande Shivam , Banerjee Biplab , Chaudhuri Subhasis 
Published: June 2020

Abstract
With recent advances in sensing, multimodal data is becoming easily available for various applications, especially in remote sensing (RS), where many data types like multispectral imagery (MSI), hyperspectral imagery (HSI), LiDAR etc. are available. Effective fusion of these multisource datasets is becoming important, for these multimodality features have been shown to generate highly accurate land-cover maps. However, fusion in the context of RS is non-trivial considering the redundancy involved in the data and the large domain differences among multiple modalities. In addition, the feature extraction modules for different modalities hardly interact among themselves, which further limits their semantic relatedness. As a remedy, we propose a feature fusion and extraction framework, namely FusAtNet, for collective land-cover classification of HSIs and LiDAR data in this paper. The proposed framework effectively utilizses HSI modality to generate an attention map using "self-attention" mechanism that highlights its own spectral features. Similarly, a "cross-attention" approach is simultaneously used to harness the LiDAR derived attention map that accentuates the spatial features of HSI. These attentive spectral and spatial representations are then explored further along with the original data to obtain modality-specific feature embeddings. The modality oriented joint spectro-spatial information thus obtained, is subsequently utilized to carry out the land-cover classification task. Experimental evaluations on three HSI-LiDAR datasets show that the proposed method achieves the state-of-the-art classification performance, including on the largest HSI-LiDAR dataset available, University of Houston (Data Fusion Contest - 2013), opening new avenues in multimodal feature fusion for classification.
Normative Beliefs and Values Shape Mother’s Care Seeking Behaviours for Skilled Birth Attendance (Sba) During Birthing in Africa: A Scoping Review Protocol
Authors: Jacobs Choolwe , Hyder Adnan 
Published: June 2020

Abstract
Background: Skilled birth attendance (SBA) during delivery has been associated with improved maternal health outcome. However, low utilisation of SBA during childbirth has continued in many developing countries including Zambia. An understanding of the beliefs and values and how mothers are influenced by relational normative motivations is critical in understanding some “hidden” barriers and facilitators to utilisation of SBA in health facilities.Methods: A scoping review of normative beliefs and values shaping care seeking behaviours for Skilled Birth Attendance by mothers in Africa will be conducted. Google scholar, PubMed, EBSCOhost, SCOPUS, Embase and WEB of Science will be searched for articles that meet the eligibility criteria. The primary search will include peer-reviewed articles. Further searches will be made on Research gate, including grey literature from university websites for dissertations and theses. We will also search reference lists for relevant articles and studies. Keyword searches will be used to identify articles. Two independent reviewers will begin screening for eligible titles, abstracts and full articles with a third reviewer to help resolve any disputes. During title and abstract screening, duplicates will be removed. Study selection will conform to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines, and the Mixed Method Appraisal Tool will determine the quality of included studies. Content analysis will be used to present the narrative Discussion: Understanding how individual mother’s health seeking behaviours for SBA and those close to them are influenced by their beliefs and values is critical to informing health systems on the possible “hidden” barriers and facilitators to utilisation of SBA in public health facilities. The review will complement evidence base on normative beliefs and values shaping care seeking behaviours for Skilled Birth Attendance by mothers in Africa.
Contrasting Cumulative Risk and Multiple Individual Risk Models of the Relationship Between Adverse Childhood Experiences (ACEs) and Adult Health Outcomes
Authors: LaNoue Marianna , George Brandon J , Helitzer Deborah L , Keith Scott W 
Published: June 2020

Abstract
Background
A majority of the documented relationships between adverse childhood experiences (ACEs) and adult health outcomes are based in cross-sectional self-reported datasources such as the CDC’s Behavioral Risk Factor Surveillance System survey. Despite using the same or similar questions, there is a great deal of inconsistency in the operationalization of self-reported childhood adversity for use as a predictor variable. A cumulative risk model, resulting in a cumulative numeric ‘ACE Score’, is normative but there are differences in the way the ACE Score is calculated and used in statistical models. Alternative conceptual models are rarely used, even though predictor characterization directly impacts interpretations about the effects of adversity on outcomes. We investigated differences in model fit and performance between the cumulative ACE Score and a ‘multiple individual risk’ model that enters individual ACE events individually into prediction models.
Methods
We merged the 2011–2012 BRFSS data (N = 56,640) and analyzed 3 self-report outcomes. We compared model fit metrics and used Vuong’s test for model selection to arrive at a best fit model.
Results
The multiple individual risk model was a better fit than the categorical ACE Score for the ‘lifetime history of depression’ outcome. For the outcomes of obesity and cardiac disease, the cumulative risk and multiple individual risks models were of comparable fit, but yield very different inferences.
Conclusions
Additional information-rich inferences about ACE-health relationships can be obtained from including a multiple individual risk modeling strategy, either in addition to or in place of a cumulative risk ACE Score.
Assessing the risk factors of preterm births in Kurdistan, Iran: a case-control study
Authors: Hemmatpour Siros , Mansori Majid , Moradi Ghobad , Sheikhahmadi Shobo , Bagheri Batool 
Published: June 2020

Abstract
Background Preterm birth is one of the most common causes of mortality in infants. Despite advances in health care and better access to health services in many countries, preterm birth has increased over the past two decades. Methods This case control study was conducted on two groups with 100 participants including 100 preterm infants (case) and 100 term infants (control) with gender match in Kurdistan Province-Iran in 2018. The required information was collected from medical files and interviewing the mothers as to demographical information, midwifery specifications, background diseases, disease over pregnancy term, and infants’ information. Conditional logistic regression test was used to estimate the final model and compute the risk ratio. Results Multivariate regression analysis showed that the risk of preterm birth in individual with AB blood type was higher (OR=5.04; 95% CI 1.40-18.08). In addition, the risk of preterm birth was higher in the mothers with a history of stillbirth (OR=13.63; 95% CI 1.39-133.5). Preterm birth was significantly related to the history of birth diseases, history of pregnancy diseases, and using medicine for specific diseases during pregnancy. Conclusions Blood type of mother, history of still birth, history of birth disease, history of pregnancy diseases, using medicines for specific diseases, and history of preterm birth were the risk factors of preterm birth. These factors need to be taken into account before and during pregnancy. Paying more attention to these factors attenuates the rate of preterm birth and premature infants and in turn the mortality rate of infants and mothers.
Effect of early oseltamivir on COVID-19-suspected outpatients without hypoxia.
Authors: Chiba Satoru 
Published: June 2020

Abstract
Background
Since December 2019, COVID-19 (corona virus disease 2019) outbreaks has occurred in China and many countries around the world. We evaluate the effectiveness of oseltamivir on COVID-19-suspected outpatients without hypoxia.
Methods
We studied 13 COVID-19-suspected medical staffs and their cohabitation families without hypoxia, who came to our adult fever clinic from March to May 2020. All patients received antiviral therapy (oseltamivir) and antibacterial therapy together.
Results
Most of the infected patients were female (8 [62%]); less than half had diabetes (one [8%]) and hypertension (three [23%]). Median age was 45 years (IQR 26–53). Oseltamivir administration made the temperature fall within 24 hours in part (8 [62%]). Clinical data were compared between patients receiving early treatment (ET) with oseltamivir, initiated within 24 hours, and patients administered late treatment (LT), initiated after this time point. Duration of fever was shorter in the ET group than in the LT group (33 ± 24 versus 94 ± 38 hours; p < 0.01). The time from fever onset to treatment initiation correlated with duration of fever (r = 0.74; p < 0.01) and the time from peak to decline (r = 0.55; p < 0.05).
Conclusions
Our findings suggest that early oseltamivir administration may lower the duration of fever in COVID-19-suspected outpatients without hypoxia when it is used in combination with antibacterial therapy.
Distributing Information in Small-World Networks: Four Social Cases of the Process of Contagion in Spain.
Authors: Belli Simone , Reyes Leonardo 
Published: June 2020

Abstract
This case study is part of a research project based in Spain between 2011 and 2014 on the social institutions and affective processes involved in what is normally referred to as social movement. Our purpose is to study how information circulates in small-world networks in which the dynamics are modeled with a stochastic version of the Greenberg-Hasting's excitable model. This is a three state model, in which a node can be in an excited, passive, or susceptible state. Only in the susceptible state does a node interact with its neighbors in the small-world network and its interaction depends on a probability of contagion. We introduce an infection probability, which is the only parameter in our implementation of the Greenberg-Hasting's model. The small-world network is characterized by a mean connectivity parameter and by a disorder parameter.The resulting dynamics are characterized by the average activity in the network. We have found transitions from inactive to active collective regimes, and we can induce this transition by varying. We search for different dynamics within small-world networks of citizens’ organizations by going through the following steps: identifying alliance patterns; looking for robust small-world attributes and how they are constructed; and interpreting the three modes of our model.
Changes in Serum Markers Failed to Predict Persistent Infection after Two-stage Exchange Arthroplasty
Authors: Jiang Qiao , Fu Jun , Chai Wei , Hao Li-bo , Zhou Yong-Gang , Xu Chi , CHEN Ji-Ying 
Published: June 2020

Abstract
Background

The 2018 International Consensus Meeting suggested that a variation trend toward normalization in serum markers was useful for determining the proper timing of reimplantation. However, the opposite results were found that by previous studies, and the normalization of serum markers was reported to fail to predict infection control. We investigated whether value changes and percent changes in four common serum markers (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinogen) can predict persistent infection?

Methods

A retrospective review of 141 patients treated with two-stage revision from 2014 to 2018 was conducted. The variation trend in serum indicators was evaluated by the percent changes (using values of serum markers prereimplantation divided by values preresection) and value changes (using values of serum markers preresection minus values prereimplantation). Treatment success was defined according to the Delphi-based consensus criteria with a minimum follow-up of 1 year, and the receiver operator characteristic (ROC) was used to examine the usefulness of changes in serum markers.

Results

22 patients (15.60%) were persistently infected. No significant difference was found in either the value change or percent change in serum markers between reinfection and non-reinfection patients. When predicting persistent infection, the area under the curves (AUC) demonstrated that both percent changes and value changes in serum markers were poor indicators. The AUC of value changes was 0.533 for the CRP, 0.504 for the IL-6, 0.508 for the ESR and 0.586 for fibrinogen when predicted persistent PJI. In addition, the AUC indicated that percent changes in the CRP (0.464), the IL-6 (0.534), the ESR (0.527) and fibrinogen (0.586) were all poor markers.

Conclusions

We have shown that both value changes and percent changes in serum markers were not sufficiently rigorous to aid in persistent infection diagnosis. The proper timing of reimplantation must therefore take into account various clinical tests rather than the downward trend of serum markers only.