bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards the Design of a Community-Engaged Data Visualization Course
Authors: Bratt Sharon 
Published: August 2020

Educational action research bridges the gap between theory and practice; where the learning design is the proposed hypothesis and the classroom is where it is field-tested by the teacher as researcher (McKernan, 2007; Stenhouse, 1975). Through this lens we see inquiry as a deepened understanding of one’s own practice. The purpose of this study was to critically evaluate the design of an introduction to data visualization course with community-engaged learning as its core pedagogy. Results show that many of the core elements of community-engaged learning were achieved at the exemplary level, based on the assessment matrix developed by Dahan and Seligsohn (2003). Several recommendations emerged, both situational and generalizable, which could enhance the redesign and improve the experience for practitioners who use community-engaged learning as a core pedagogy.
O CONFRONTO SOCIAL E JURÍDICO NOS CASOS DE TRANSFUSÃO DE SANGUE EM TESTEMUNHAS DE JEOVÁ
Authors: Silva Maria Elenie Alves da 
Published: August 2020

Este artigo tratará dos direitos constitucionais à vida, à liberdade religiosa e a saúde pública, nos tratamentos médicos que necessitam de transfusões de sangue e seus derivados. Demonstrar os direitos e garantias constitucionais fundamentais a todos nós cidadãos brasileiros, pois o nosso país é declaradamente um país laico, o que significa e quais as suas consequências, questionamentos que relataremos no artigo que segue. O tema aborda questões relacionadas à dignidade da pessoa humana, direito assegurado pela constituição brasileira, na qual a doutrina demonstra que o cidadão precisa ter o mínimo de condições para dignificar seus atos, tais como nascer, crescer, desenvolver-se e ter uma vida confortável; tema que irei abordar também será o posicionamento de cada lado do problema, bem como a questão que envolvem biodireito e bioética dentro do tema abordado. É um dever do Estado garantir a saúde e o bem-estar de seus cidadãos, dever esse concretizado no direito fundamental e social; o direito a saúde pública que também se encontra positivado em nossa constituição, relatarei qual a orientação que o conselho de medicina passa aos servidores da saúde, ao se depararem diante do caso concreto perante aos seguidores testemunhas de Jeová no que diz respeito as recusas diante da necessidade de uma transfusão de sangue, o médico deve respeitar a vontade deste paciente e de seus familiares?
Identification of Genetic Alterations by Circulating Tumor DNA in Leiomyosarcoma: A Molecular Analysis of 73 Patients
Authors: Arshad Junaid , Barreto-Coelho Priscila , Jonczak Emily , Espejo Andrea , D'Amato Gina , Trent Jonathan C. 
Published: August 2020

ABSTRACT

Background
Leiomyosarcoma is a malignant mesenchymal tumor of cells of smooth muscle lineage arising commonly in retroperitoneum, uterus, large veins, and the limbs. The genetics of leiomyosarcomas are complex and there is very limited understanding of common driver mutations. Circulating tumor DNA (ctDNA) offers a rapid and noninvasive method of next-generation sequencing (NGS) that could be used for diagnosis, therapy, and detection of recurrence.

Methods
ctDNA testing was performed using Guardant360, which detects single nucleotide variants, amplifications, fusions, and specific insertion/deletion mutations in 73 genes using NGS.

Results
Of 73 patients, 59 were found to have one or more cancer-associated genomic alteration. Forty-five (76%) were female with a median age of 63 (range, 38–87) years. All samples were designated metastatic. The most common alterations were detected in Tp53 (65%), BRAF (13%), CCNE (13%), EGFR (12%), PIK3CA (12%), FGFR1 (10%), RB1(10%), KIT (8%), and PDGFRA (8%). Some of the other alterations included RAF1, ERBB2, MET, PTEN TERT, APC, and NOTCH1. Potentially targetable mutations, by Food and Drug Administration–approved or clinical trials, were found in 24 (40%) of the 73 patients. Four patients (5%) were found to have incidental germline TP53 mutations.

Conclusion
NGS of ctDNA allows identification of genomic alterations in plasma from patients with leiomyosarcoma. Unfortunately, there is limited activity of current targeted agents in leiomyosarcomas. These results suggest opportunities to develop therapy against TP53, cell cycle, and kinase signaling pathways. Further validation and prospective evaluation is warranted to investigate the clinical utility of ctDNA for patients with leiomyosarcoma.
Nurses' Perception of Safety on Hospital Interior Environments and Infectious Diseases: An Exploratory Study
Authors: Bae Suyeon , Asojo Abimbola O. 
Published: August 2020

ABSTRACT

Introduction
Healthcare environments consist of a variety of different fomites containing infectious agents. From the 2003 outbreaks of Severe Acute Respiratory Syndrome to the recent concerns about the Ebola and Zika viruses, interest in the role of healthcare environment fomites in spreading infectious diseases has increased. Because of a high risk of being exposed to infections, the goal of this study was to learn how hospital interior environments impact nurses' perceptions of safety about infectious diseases.

Methods
Semistructured, in-depth interviews were conducted with six nurses at a public hospital.

Results
The following three themes were identified: (1) perceptions of safety from infectious diseases were diverse among the participants; (2) various interior environments in hospital settings can prevent as well as promote the spreading of infectious diseases; and (3) the different perceptions influenced the ways participants developed their contrasting behaviors of treating interior environments to cope with their fears (e.g., how they open doors).

Conclusion
The findings from this study contribute to the existing body of knowledge on designing hospital interior environments to better understand nurses' perception of infectious diseases.
The Origin of Feminism and the Feminist Movement in the Late 18th — Early 19th Centuries
Authors: Захарова О.В. , Нойкова Е.А. 
Published: August 2020

Вторая половина XVIII века в истории Европы богата не только войнами, революциями, колониальной политикой и множеством важных научных, технических и культурных открытий, но также и коренным социальными преобразованиями на европейском общественном пространстве. Именно эпоха Просвещения заложила начало к переоценке женщины как независимой личности, способной на равных правах с мужчинами полноценно участвовать в экономической, политической и производственной деятельности. Период протофеминизма дает богатый исторический материал о начале зарождения первых женских движений, лозунгов и выдвигаемых требований. На данном этапе появляются первые борцы за равноправие между мужчинами и женщинами, первые праматери феминистских движений, заложившие основы и постулаты для будущих поколений, появляются первые труды и первые произведения, положившие начало движению к равноправной гендерной свободе и борьбе женщин за свои права.
In the late 18th century, Europe witnessed many wars, revolutions, colonial oppression, but it also saw many important scientific, technical and cultural discoveries and dramatic social changes. The Age of Enlightenment reassessed the role of women as independent personalities who can fully participate in economics, politics and manufacturing at par with men. Protofeminism anticipated modern feminism with its mottos and aspirations. In that era, there appeared first activists fighting for gender equality, forerunners of the feminist movement who formulated the principles of feminism. There appeared first works which lay the foundation of the gender equality movement and initiated womenʼs struggle for their rights.
Jet Properties of Compact Steep-spectrum Sources and an Eddington-ratio-driven Unification Scheme of Jet Radiation in Active Galactic Nuclei
Authors: Zhang Jin , Zhang Hai-Ming , Gan Ying-Ying , Yi Ting-Feng , Wang Jun-Feng , Liang En-Wei 
Published: August 2020

Abstract
Compact steep-spectrum sources (CSSs) likely represent a population of young radio-loud active galactic nuclei (AGNs) and have been identified as γ-ray-emitting sources. We present a comprehensive analysis of their γ-ray emission observed with Fermi/LAT and establish their broadband spectral energy distributions (SEDs). We derive their jet properties using SED fits with a two-zone leptonic model for radiation from the compact core and the large-scale extended region, and explore the possible signature of a unification picture of jet radiation among subclasses of AGNs. We show that the observed γ-rays of CSSs with significant variability are contributed by the radiation of their compact cores via the inverse-Compton process of the torus photons. The derived power-law distribution index of the radiating electrons is p
1 ∼ 1.5–1.8, magnetic field strength is B ∼ 0.15–0.6 G, and Doppler-boosting factor is δ ∼ 2.8–8.9. Assuming that the jet is composed of e
± pairs, the compact cores of CSSs are magnetized and have a high radiation efficiency, similar to that of flat-spectrum radio quasars. The γ-ray-emitting CSSs on average have higher Eddington ratio and black hole mass than those non-GeV-detected CSSs, and they follow the correlation between the jet power in units of Eddington luminosity (

) and Eddington ratio (R
Edd) with other subclasses of AGNs,

, indicating that R
Edd would be a key physical driver for the unification scheme of AGN jet radiation.
Does Matter Matter? Using the Mass Distribution to Distinguish Neutron Stars and Black Holes
Authors: Fishbach Maya , Essick Reed , Holz Daniel E. 
Published: August 2020

Abstract
Gravitational-wave detectors have opened a new window through which we can observe black holes (BHs) and neutron stars (NSs). Analyzing the 11 detections from LIGO/Virgo’s first gravitational-wave catalog, GWTC-1, we investigate whether the power-law fit to the BH mass spectrum can also accommodate the binary neutron star (BNS) event GW170817, or whether we require an additional feature, such as a mass gap in between the NS and BH populations. We find that with respect to the power-law fit to binary black hole (BBH) masses, GW170817 is an outlier at the 0.13% level, suggesting a distinction between NS and BH masses. A single power-law fit across the entire mass range is in mild tension with (a) the detection of one source in the BNS mass range (∼1–2.5 M
⊙), (b) the absence of detections in the “mass-gap” range (∼2.5–5 M
⊙), and (c) the detection of 10 sources in the BBH mass range (≳5 M
⊙). Instead, the data favor models with a feature between NS and BH masses, including a mass gap (Bayes factor of 4.6) and a break in the power law, with a steeper slope at NS masses compared to BH masses (91% credibility). We estimate the merger rates of compact binaries based on our fit to the global mass distribution, finding

and

. We conclude that, even in the absence of any prior knowledge of the difference between NSs and BHs, the gravitational-wave data alone already suggest two distinct populations of compact objects.
Prevalence and associated risk factors of intestinal parasitic infections among primary school children at Bure town, north-west Ethiopia
Authors: Sitotaw Baye , Gebeyaw Yezina , Mekonnen Haile 
Published: August 2020

The burden of intestinal parasitic infections (IPIs) has been a common problem on children in Ethiopia. While communities in Bure town, northwest Ethiopia, are presumed to be exposed to IPIs, no study has been conducted before. The aim of this study was therefore to assess the prevalence of IPIs and associated risk factors among school children in Bure town by conducting a cross-sectional study from January to June 2019. A total of 430 students were selected using stratified systematic random sampling technique. Direct wet-mount and formal-ether concentration techniques were used for parasitological analysis from stool samples taken from each student. Information about the risk factors was collected using structured questionnaire. Data were analyzed using SPSS version 24. The overall prevalence of IPIs among the children involved in the study was found to be 40% (172/430). Some 37.7% of the students exhibited single parasite infection, 2.1% double and 0.23% triple parasite. Seven species of intestinal parasites were detected, and Entamoeba histolytica/dispar was the most prevalent parasite (22.1%) followed by Giardia lamblia (8.6%), hookworms (6.75%) and Ascaris lumbricoides (3.7%). Hymenolepis nana, Trichuris trichuira and Taenia species were rare (<1% prevalence each). Knowledge about personal and food hygiene as well as environmental sanitation were the most important predictors for IPIs (P<0.05). Primary school children in Bure town are at high risk of IPIs. Awareness creation on personal hygiene and environmental sanitation is strongly recommended.
Keywords: Intestinal parasitic infections; Prevalence; Primary school children; Risk factor; Bure town
“Being fat is not a disease but a sign of good living”: The Political Economy of Overweight and Obesity in Nigeria
Authors: Osayomi Tolulope 
Published: August 2020

Increasing overweight and obesity rates have accompanied economic development in recent years. This twofold health issue has become increasingly worrisome and is currently receiving academic interest and government attention. A growing volume of studies has examined the demographic, socio economic, environmental and cultural risk factors of overweight and obesity in Nigeria where fatness is culturally revered. However, information on large scale factors associated with economic development shaping the geographical distribution of overweight and obesity is sparse. From the political economic standpoint, the central question of this paper is: ‘Does the spatial pattern of overweight and obesity correspond with the varying levels of economic development in Nigeria? The study relied on secondary data from published sources. Linear regression models were estimated to determine the impact of economic development variables on overweight and obesity. Results reveal that percent population with white collar jobs had a significant positive effect on overweight whereas poverty, gross domestic product (GDP) and degree of urbanization were significantly related to obesity. The paper concludes that the spatial patterns of overweight and obesity follow the pathways of economic development in Nigeria.
Satisfação e motivação no trabalho: insights sobre percepção da justiça distributiva e remuneração estratégica por indivíduos da Geração Z
Authors: Spagnol Simi dos Santos Silvia , Olivo Ana Maria , Petry David Rodrigo , Oro Ieda Margarete 
Published: August 2020

A justiça organizacional é assunto contemporâneo que passou a ser observada pelas organizações em função da Geração Z. Este estudo objetiva verificar a relação existente entre justiça distributiva, remuneração estratégica e os fatores de satisfação e motivação de indivíduos da Geração Z no mercado de trabalho. Como metodologia optou-se pela abordagem quantitativa por intermédio de survey online enviado para 13.000 indivíduos pertencentes a essa geração, resultando em uma amostra de 1.112 pessoas. A análise dos resultados foi realizada com utilização dos softwares SPSS® e AMOS®, e das ferramentas de análise fatorial e modelagem de equações estruturais. A partir das hipóteses testadas foi possível verificar que a percepção de Justiça Distributiva e da Remuneração Estratégica influenciam na Motivação e na Satisfação de indivíduos da Geração Z no mercado de trabalho. Os achados revelam que não é o tipo de remuneração que é o mais importante, mas a percepção de ganhos.
Studio Companion Series Drafting Basics
Authors: Fullmer Donna Lynne 
Published: August 2020

The Studio Companion Series consists of four books, available separately or as a set, which provide a launch pad into the study of design and architecture. Clear instructions and a wealth of examples give students a comprehensive look at the entire design process, from concept to presentation. Developed for today's student, the books present material in a contemporary and graphic manner and are compact and highly portable. The series incl	udes: Design Basics, Drafting Basics, 3D Design Basics, and Presentation Basics.
Drafting Basics offers an introduction to the art of hand drafting using lead and ink. Students will first learn how to communicate through fundamental two-dimensional drawings including lettering, plans, elevations, and sections. The book then covers the basics of technical drafting, reinforcing the importance of the hand skills required of interior design professionals at every point along the career path.
Associations between human leukocyte antigen C locus polymorphism and psoriatic arthritis in populations of European and Middle Eastern descent: a meta-analysis
Authors: Shao Lin-Nan , Wang Ni , Zhou Shi-Hang , Wang Zi 
Published: August 2020

ABSTRACT

BACKGROUND:
Gene-disease association between human leukocyte antigen (HLA)-C locus polymorphism and psoriatic arthritis (PsA) remains controversial.

OBJECTIVE:
Evaluate the relationship between HLA-C locus polymorphism and PsA in populations of European and Middle Eastern descent.

SEARCH METHODS:
PubMed, PMC, Elsevier and Google Scholar databases from 1980 to January 2020. The search was limited to articles in English.

SELECTION CRITERIA:
Case-control studies (with unrelated participants) that had allele/genotype data on the association between HLA-C locus polymorphism and PsA susceptibility.

DATA COLLECTION AND ANALYSIS:
Two investigators searched independently in searching the literature. Disagreements were resolved by discussion and consultation with a third researcher. The Q-Genie tool was used to assess the quality of articles.

RESULTS:
Twenty-five studies met the inclusion criteria. At the allelic level, three alleles were associated with an increased risk of PsA and five were associated with a reduced risk. At the phenotypic level, four alleles were associated with increased risk of PsA and three were associated with a reduced risk. At both the allelic and phenotypic levels, the results revealed that HLA-C*04 played a protective role in PsA (The pooled odds ratio [OR] is 0.66 for allelic level and 0.63 for phenotypic level), while HLA-C*02, *06 and *12 increased the risk of suffering from PsA (The pooled ORs of C*02, *06 and *12 are 2.21, 2.63 and 1.49 for allelic level, and 1.79, 2.96 and 2.25 for phenotypic level, respectively).

CONCLUSION:
The pooled results showed a significant association between PsA and the HLA-C gene in populations of European and Middle Eastern descent. At both the allelic and phenotypic levels, the HLA-C*02, *06 and *12 may contribute to susceptibility to PsA, while HLA-C*04 may confer a protective role against PsA.

REGISTRATION:
Not registered.

CONFLICT OF INTEREST:
None.
Classificação Internacional para a Prática de Enfermagem em dissertações e teses brasileiras
Authors: Clares Jorge Wilker Bezerra , Guedes Maria Vilaní Cavalcante , Freitas Maria Célia de 
Published: August 2020

Objetivou-se descrever o uso da Classificação Internacional para a Prática de Enfermagem (CIPE®) em dissertações e teses desenvolvidas nos programas de pós-graduação stricto sensu brasileiros. Estudo documental e quantitativo, realizado a partir de teses e dissertações, publicadas de 2000 a 2018, nos catálogos do Centro de Estudos e Pesquisas em Enfermagem da Associação Brasileira de Enfermagem e no portal de periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Elegeram-se 26 teses e 92 dissertações. Verificou-se crescimento da produção acadêmica sobre a CIPE®, com predominância de estudos do tipo metodológico (36,1%), com abordagem quantitativa (89,8%), oriundos da região Nordeste (45,8%), voltados para a prática assistencial (88,2%), com temáticas relacionadas à saúde do adulto (45,3%), e descritores relacionados à Enfermagem. Os indicadores avaliados possibilitaram desvelar padrões de pesquisa e identificar tendências nos estudos de pós-graduação stricto sensu, que poderão direcionar a condução de novas investigações sobre a CIPE®.
Descritores: Enfermagem; Classificação; Terminologia; Pesquisa em Enfermagem; Educação de Pós-Graduação em Enfermagem.
Comme des perles dans la nuit : lecture de Batman et réflexivité du détail
Authors: Mellier Denis 
Published: August 2020

Si les formes de la réécriture transmédiatique et transfictionnelle jouent sur des caractéristiques générales de la fiction matrice ou sur des effets de rupture, de subversion ou de révérence aux éléments du Canon qui fixe les règles du jeu transtextuel, qu’en est-il quand le moteur de toute cette production d’avatars et de versions est un simple instant, un geste, une image, qui se sont imposés au coeur même d’une des stations constitutives du récit. Le jeune Bruce Wayne trouve sa vocation de justicier nocturne et schizée dans le meurtre de ses parents. L’assassin se saisit du collier de perles qui cède et celles-ci s’envolent en l’air, se répandent dans la case, roulent dans la planche, et continuent dès lors d’essaimer formellement et sur le plan figural dans un Batmanverse qu’elles occupent de leur présence visuelle : traces, archives, mémoires ou figures obsédantes? On s’interrogera sur la façon dont l’étude figurale et le réemploi d’un motif visuel ténu, minimal et local, peuvent servir un processus d’engendrement des images qui nourrit une forme de réflexivité spécifique à travers le corpus intermédial de la geste deBatman.
Proteomic analysis of exudate of Cercospora armoraciae from Armoracia rusticana
Authors: Wang Haining , Wei Songhong , Yang Xiaohe , Liu Wei , Zhu Lijun 
Published: August 2020

Background
Cercospora armoraciae causes leaf spot disease on Armoracia rusticana. Exudation of droplets, when grown on PDA, distinguishes this fungi from other members of the genus Cercospora. The role this exudate plays in the virulence of this pathogen has not been elucidated. To explore this, we characterized the transcriptome of C. armoraciae and the proteome of exudate associated with this plant pathogen.

Methods
Virulence of three strains of C. armoraciae was evaluated in greenhouse assays. De novo sequencing was applied to assemble transcriptome from these strains. Nano-HPLC-MS/MS analysis was used to identify proteins in the pathogen exudate. Identified proteins were functionally classified and annotated using GO, KEGG, and COG/KOG bioinformatics analysis methods.

Results
When treated with the exudate of C. armoraciae strain SCa-01, leaves of A. rusticana showed yellowing and necrosis of the leaves and similar symptoms to plants inoculated with this fungi. A total of 14,937 unigenes were assembled from C. armoraciae, and 576 proteins comprising 1,538 peptides, 1,524 unique peptide, were identified from the exudate. GO annotation classified 411 proteins (71%) into 27 functional categories, namely, 12, seven and eight biological process, cellular component, and molecular function subcategories, respectively. KEGG analysis assigned 314 proteins to 84 signaling/metabolic pathways, and 450 proteins were annotated against the COG/KOG database.

Discussion
Transcriptome and GO analysis of C. armoraciae found most proteins in the exudate. GO analysis suggested that a considerable proportion of proteins were involved in cellular process and metabolic process, which suggests exudates maintain the metabolic balance of this fungi. Some proteins annotated to the phenylalanine metabolism, which suggests that the exudates may enhance the virulence of this pathogen. Some proteins annotated to the phenylalanine metabolism, which suggests that the exudates may enhance the pathogenicity of the pathogen. Also some proteins were annotated to the peroxisome metabolic pathway and the fatty acid biosynthesis pathways. These pathways may confer antifungal, antioxidant and antimicrobial activity on the exudates.