bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational noise-induced hearing loss in China: a systematic review and meta-analysis
Authors: Zhou Jiena , Shi Zhihao , Zhou Lifang , Hu Yong , Zhang Meibian 
Published: September 2020

ObjectiveMost of the Chinese occupational population are becoming at risk of noise-induced hearing loss (NIHL). However, there is a limited number of literature reviews on occupational NIHL in China. This study aimed to analyse the prevalence and characteristics of occupational NIHL in the Chinese population using data from relevant studies.DesignSystematic review and meta-analysis.MethodsFrom December 2019 to February 2020, we searched the literature through databases, including Web of Science, PubMed, MEDLINE, Scopus, the China National Knowledge Internet, Chinese Sci-Tech Journal Database (weip.com), WanFang Database and China United Library Database, for studies on NIHL in China published in 1993–2019 and analysed the correlation between NIHL and occupational exposure to noise, including exposure to complex noise and coexposure to noise and chemicals.ResultsA total of 71 865 workers aged 33.5±8.7 years were occupationally exposed to 98.6±7.2 dB(A) (A-weighted decibels) noise for a duration of 9.9±8.4 years in the transportation, mining and typical manufacturing industries. The prevalence of occupational NIHL in China was 21.3%, of which 30.2% was related to high-frequency NIHL (HFNIHL), 9.0% to speech-frequency NIHL and 5.8% to noise-induced deafness. Among manufacturing workers, complex noise contributed to greater HFNIHL than Gaussian noise (overall weighted OR (OR)=1.95). Coexposure to noise and chemicals such as organic solvents, welding fumes, carbon monoxide and hydrogen sulfide led to greater HFNIHL than noise exposure alone (overall weighted OR=2.36). Male workers were more likely to experience HFNIHL than female workers (overall weighted OR=2.26). Age, noise level and exposure duration were also risk factors for HFNIHL (overall weighted OR=1.35, 5.63 and 1.75, respectively).ConclusionsThe high prevalence of occupational NIHL in China was related to the wide distribution of noise in different industries as well as high-level and long-term noise exposure. The prevalence was further aggravated by exposure to complex noise or coexposure to noise and specific chemicals. Additional efforts are needed to reduce occupational noise exposure in China.
The effects of Sc doping and O vacancy on the electronic states and optical properties of m-BiVO4
Authors: Huang Yuhong , Zhang Xiaqing , Wang Jingnan , Zhang Jianmin , Wei Xiumei , Ma Fei 
Published: September 2020

Based on density functional theory (DFT), the effects of scandium (Sc) doping and oxygen vacancy (VO) on the electronic states and optical properties of monoclinic BiVO4 (m-BiVO4) are investigated. The generalized gradient approximation plus U (GGA+U) method is adopted during the calculation of the electronic properties to compensate for the limitations of the DFT method. The ideal m-BiVO4 has a direct band gap of 2.400 eV, and if Bi in m-BiVO4 is substituted by Sc (subSc-Bi), the direct band gap will be reduced to 2.393 eV. However, if V is replaced by Sc (subSc-V) as well as oxygen vacancy induced (subSc–V+VO), the band gap will become indirect with values of 1.913 and 2.198 eV, respectively. The reduction capability is in the sequence of subSc–Bi > ideal > subSc–V+VO > subSc–V, while the oxidation capability is in the order of ideal > subSc–Bi > subSc–V+VO > subSc–V. The ε1(0) of the ideal, subSc–Bi, subSc–V, and subSc–V+VO defective m-BiVO4 are 8.290, 8.293, 12.791, and 8.285, respectively. The optical absorptions of ideal and subSc–Bi m-BiVO4 show anisotropy and they are nearly independent of the defect concentration. SubSc–V m-BiVO4 exhibits stronger absorption than the other three semiconductors. The absorptions of subSc–V+VO m-BiVO4 vary widely with the defect concentrations, where 3.906% defect concentration of m-BiVO4 has the strongest absorption. The estimated optical band gaps [Formula: see text] are smaller than Eg for ideal and defective m-BiVO4.
The Pliocene deposits of the Black Sea Shelf east of the Danube River Delta
Authors: Gozhik Petro F. , Rokitsky Valery E. 
Published: September 2020

Abstract
This paper provides analysis of the published materials on the occurrences of the Dacian and Cimmerian molluscs in the Danube River valley as well as the results of Pliocene sediments study based on core material of the boreholes drilled at the Black Sea Shelf east of the Danube River Delta.

In the early Pontian time, the Dacian Basin was a large sub-basin of Paratethys which, due to an abrupt drop in sea level, separated into the Euxinian, Dacian and Caspian basins. At the end of the Bosphorus time, the discharge of the Dacian Basin waters into the Euxinian Basin formed a wide valley from the Galati-Reni region to the east through the Galati gateway. During the Cimmerian transgression, a vast bay existed on the site of the modern Danube Delta, from which mutual migrations of the Dacian and Cimmerian molluscs took place along the runoff valley. The cessation of runoff occurred during the regressive phase of the Late Cimmerian. The rhythmically bedded thick strata originated during the existence of the runoff valley. These strata were identified as the Pridanubian Formation (Suite). The cryptogenic form of
Tulotoma Tulotoma
(
=Viviparus
)
ovidii nasonis
(Bogachev) is characteristic of the lower and middle parts of the suite. The presence of the Dacian and Cimmerian molluscs in this suite became the basis for the correlation of sediments of the Dacian and Cimmerian regional stages. The Duabian molluscs were registered in the Cimmerian deposits of the Transcaucasus (the Duabian layers), Priazovye and the Kerch–Taman region. The migration of these molluscs took place during the regressive phases due to the circular current in the Euxinian Basin similar to the one existing in the Black Sea today.

The Pliocene formation contains marine and continental deposits of the Lower and Upper Pliocene, which are represented by the Pridanubian Formation (Lower and Upper), Cimmerian deposits (non-subdivided Lower and Middle Cimmerian), Lower Kujalnician deposits, Upper Poration deposits, complex of red-coloured palaeosols (the Upper Miocene–Lower Pliocene non-subdivided).
The formation of the Pliocene sediments on the Black Sea Shelf, east of the Danube Delta, was controlled by the inter-basin connectivity of the Eastern Paratethys.
Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death
Authors: Sakuma Stephen , Raices Marcela , Borlido Joana , Guglielmi Valeria , Zhu Ethan Y.S. , D'Angelo Maximiliano A. 
Published: September 2020

AbstractNuclear pore complexes (NPC) are the central mediators of nucleocytoplasmic transport. Increasing evidence shows that many cancer cells have increased numbers of NPCs and become addicted to the nuclear transport machinery. How reducing NPC numbers affects the physiology of normal and cancer cells and whether it could be exploited for cancer therapies has not been investigated. We report that inhibition of NPC formation, a process mostly restricted to proliferating cells, causes selective cancer cell death, prevents tumor growth, and induces tumor regression. Although cancer cells die in response to NPC assembly inhibition, normal cells undergo a reversible cell-cycle arrest that allows them to survive. Mechanistically, reducing NPC numbers results in multiple alterations contributing to cancer cell death, including abnormalities in nuclear transport, catastrophic alterations in gene expression, and the selective accumulation of DNA damage. Our findings uncover the NPC formation process as a novel targetable pathway in cancer cells.Significance:Reducing NPC numbers in cancer cells induces death, prevents tumor growth, and results in tumor regression. Conversely, normal cells undergo a reversible cell-cycle arrest in response to inhibition of NPC assembly. These findings expose the potential of targeting NPC formation in cancer.This article is highlighted in the In This Issue feature, p. 1
Feições tafonômicas em macrorrestos vegetais holocenos da zona costeira do município de Camocim, Ceará
Authors: Xavier Sérgio Augusto Santos , Viana Maria Somália Sales 
Published: September 2020

O município de Camocim, localizado na costa cearense, caracteriza-se por planícies e tabuleiros pré-litorâneos com a presença de largas faixas de dunas móveis, além de trechos com eolianitos que podem conter restos vegetais preservados em seu conteúdo. Nesta pesquisa, objetivou-se caracterizar os processos tafonômicos que preservaram esses macrorrestos vegetais. O trabalho de campo consistiu em observação direta de um afloramento de sedimentos eólicos diagenizados e dos vegetais mineralizados neles contidos, verificando a disposição e os tipos dos restos orgânicos. Os sedimentitos foram observados e descritos no campo e posteriormente no laboratório, sob microscópio estereoscópico, para análise de sua granulometria, tipo de cimento e litificação. Os macrorrestos vegetais mineralizados constituem uma assembleia autóctone/parautóctone de tubos horizontais e/ou verticais in situ, dentro ou ao redor do afloramento, circunvalados por exemplares menores apresentando feições de deformação e fragmentação, preservados por meio de calcificação e incrustação. A presença desses restos vegetais antigos, preservados em posição de vida, contribui para a compreensão da dinâmica sedimentar que atuou na região, permitindo o cruzamento de dados com os processos atuais.
A Unique Population of Regulatory T Cells in Heart Potentiates Cardiac Protection From Myocardial Infarction
Authors: Xia Ni , Lu Yuzhi , Gu Muyang , Li Nana , Liu Meilin , Jiao Jiao , Zhu Zhengfeng , Li Jingyong , Li Dan , Tang Tingting , Lv Bingjie , Nie Shaofang , Zhang Min , Liao Mengyang , Liao Yuhua , Yang Xiangping , Cheng Xiang 
Published: September 2020

Background:
Regulatory T cells (Tregs), traditionally recognized as potent suppressors of immune response, are increasingly attracting attention because of a second major function: residing in parenchymal tissues and maintaining local homeostasis. However, the existence, unique phenotype, and function of so-called tissue Tregs in the heart remain unclear.

Methods:
In mouse models of myocardial infarction (MI), myocardial ischemia/reperfusion injury, or cardiac cryoinjury, the dynamic accumulation of Tregs in the injured myocardium was monitored. The bulk RNA sequencing was performed to analyze the transcriptomic characteristics of Tregs from the injured myocardium after MI or ischemia/reperfusion injury. Photoconversion, parabiosis, single-cell T-cell receptor sequencing, and adoptive transfer were applied to determine the source of heart Tregs. The involvement of the interleukin-33/suppression of tumorigenicity 2 axis and Sparc (secreted acidic cysteine-rich glycoprotein), a molecule upregulated in heart Tregs, was further evaluated in functional assays.

Results:

We showed that Tregs were highly enriched in the myocardium of MI, ischemia/reperfusion injury, and cryoinjury mice. Transcriptomic data revealed that Tregs isolated from the injured hearts had plenty of differentially expressed transcripts in comparison with their lymphoid counterparts, including heart-draining lymphoid nodes, with a phenotype of promoting infarct repair, indicating a unique characteristic. The heart Tregs were accumulated mainly because of recruitment from the circulating Treg pool, whereas local proliferation also contributed to their expansion. Moreover, a remarkable case of repeatedly detected T-cell receptor of heart Tregs, more than that of spleen Tregs, suggests a model of clonal expansion. Besides, Helios
high
Nrp-1
high
phenotype proved the mainly thymic origin of heart Tregs, with a small contribution of phenotypic conversion of conventional CD4
+
T cells, proved by the analysis of T-cell receptor repertoires and conventional CD4
+
T cells adoptive transfer experiments. The interleukin-33/suppression of tumorigenicity 2 axis was essential for sustaining heart Treg populations. Last, we demonstrated that Sparc, which was highly expressed by heart Tregs, acted as a critical factor to protect the heart against MI by increasing collagen content and boosting maturation in the infarct zone.

Conclusions:
We identified and characterized a phenotypically and functionally unique population of heart Tregs that may lay the foundation to harness Tregs for cardioprotection in MI and other cardiac diseases.
A successful multiple litter adoption in a nursing southern black-eared opossum, Didelphis aurita (Didelphimorphia, Didelphidae)
Authors: Toledo Gabriela , Astúa Diego 
Published: September 2020

Abstract
Adoption by an alloparent of an offspring or a litter occurs in at least eight mammal orders, but is rare in marsupials, and was never confirmed in opossums. Here we report the first unequivocal and documented successful event of alloparental adoption of two distinct litters by a single captive female Southern Black-eared Opossum Didelphis aurita (Didelphimorphia, Didelphidae). The female, still nursing her biological litter, accepted and nursed the two offered litters. All three litters were raised simultaneously, and the female cared for and displayed protective behaviour indistinctively of the biological or adopted pups. She was kept captive until released along with her biological litter, which was weaned and fled independently, and the two adoptive litters clinging on her back. This event sheds additional light on the little known social and maternal behaviour of opossums, suggesting it is possibly more complex than originally thought.
Analysis of the Characteristics of a Team Working in Conditions of Exposure (Hospice Environment)
Authors: Trylińska-Tekielska Elżbieta 
Published: September 2020

Background The aim of the study was to examine the functioning of the team, working in conditions of exposure and finding reasons for which a specific group takes actions in conditions of life threatening others or own. The population being studied is a hospice team (N = 229). Methods Logistic regression analysis and multidimensional correspondence analysis were used in the research. Results The level of personal religiosity was regulated in a different way in the respective surveyed professional groups. In the group of hospice volunteers we managed to build 2 models, in the hospice employees – 4 models, in the group of volunteers - 5 models. Conclusion There are different types of motivation and a sense of identity. The highest level of guilt is declared by a group of hospice volunteers. In the group of volunteers of the hospice: the thanatological anxiety and mood stimulate the growth of personal religiousness.
Prevalence of and Associations With Distress and Professional Burnout Among Otolaryngologists: Part II, Attending Physicians
Authors: Carlson Matthew L. , Larson David P. , O’Brien Erin K. , Lohse Christine M. , Kircher Matthew L. , Gurgel Richard K. , Hunter Jacob B. , Micco Alan G. , Nogan Stephen J. , O’Connell Brendan P. , Rangarajan Sanjeet V. , Rivas Alejandro , Sweeney Alex D. , Wanna George B. , Weisskopf Peter A. , Choby Garret 
Published: September 2020

ObjectiveTo ascertain the prevalence of and associations with distress and professional burnout among academic otolaryngology attending physicians.Study DesignCross‐sectional survey.SettingTwelve US academic otolaryngology programs.MethodsA questionnaire was administered that encompassed sociodemographic and professional features, the Expanded Physician Well‐being Index for distress, the 2‐item Maslach Burnout Inventory for professional burnout, the Patient Health Questionnaire–2 screen for major depressive disorder, and the Generalized Anxiety Disorder–2 screen for generalized anxiety disorder.ResultsThe survey response rate was 56% and included 186 attending physicians. The average respondent age was 47 years; 72% were men; 93% were married or partnered; and 86% had children. Distress was present in 40%, professional burnout in 26%, positive depression screening in 8%, and positive anxiety screening in 11%. In a univariable setting, age, hours worked in a typical week, nights on call in a typical week, and years of practice were significantly associated with distress, although in a multivariable setting, only hours worked in a typical week remained significantly associated with a positive Expanded Physician Well‐being Index screen (odds ratio for each 10‐hour increase, 2.61; 95% CI, 1.73‐3.93; P <. 001). In a univariable setting, hours worked in a typical week was significantly associated with a positive Maslach Burnout Inventory screen.ConclusionDistress or professional burnout occurs in more than a quarter of academic otolaryngology attending physicians, whereas the prevalence of depression or anxiety is approximately 10%. The number of hours worked per week had the strongest association with distress and burnout. These findings may be used to develop and implement programs to promote physician well‐being and mitigate professional burnout.
Changes in Tendon Elongation and Muscle Atrophy Over Time After Achilles Tendon Rupture Repair: A Prospective Cohort Study on the Effects of Early Functional Mobilization
Authors: Aufwerber Susanna , Edman Gunnar , Grävare Silbernagel Karin , Ackermann Paul W. 
Published: September 2020

Background: Early functional mobilization (EFM) may improve patient outcome after Achilles tendon rupture (ATR). However, whether EFM affects patient outcome via changes in tendon elongation, thickening, or calf muscle atrophy is unknown. Purpose: To analyze differences in tendon and muscle morphology recovery over time between groups treated with EFM or standard treatment after ATR repair. Study Design: Cohort study; Level of evidence, 2. Methods: This prospective cohort study included 86 patients (20 women) with ATR repair who had a mean (SD) age of 39.3 (8.2) years and were part of a larger prospective randomized controlled trial. Patients were postoperatively randomized to immediate postoperative weightbearing and ankle motion (EFM group) or to immobilization in a below-knee plaster cast for 2 weeks (control group). Patient-reported and functional outcomes were assessed at 6 and 12 months with the Achilles Tendon Total Rupture Score and the heel-rise test for endurance. At 2 and 6 weeks and 6 and 12 months postoperatively, B-mode ultrasound imaging was performed to assess the length and cross-sectional area (CSA) of the Achilles tendon, the gastrocnemius CSA, as well as the thickness of soleus. Results: The Achilles Tendon Total Rupture Score for the EFM and control groups were 65.8 (18.7) and 56.8 (20.1; P = .045), respectively, at 6 months and 79.6 (15.8) and 78.9 (17.2; P = .87), respectively, at 12 months. At 2 weeks, tendon elongation was significantly more pronounced in the EFM group as compared with the control group (mean side-to-side difference, 1.88 cm vs 0.71 cm; P = .005). Subsequently, tendon elongation increased in the control group while it decreased in the EFM group so that at 6 and 12 months no significant differences between groups were found. Mean Achilles tendon elongation at 1 year was 1.73 (1.07) cm for the EFM group (n = 55) and 1.67 (0.92) cm for the control group (n = 27), with a mean difference of 0.06 cm (95% CI, 0.54 to –0.42; P = .80). Achilles tendon CSA and calf muscle atrophy displayed no significant differences between the groups; however, significant changes were demonstrated over time ( P ≤ .001) in both groups. Conclusion: EFM results in more Achilles tendon elongation at early healing, but this difference subsides over time. EFM does not seem to affect patient outcome via changes in tendon elongation, thickening, or calf muscle atrophy. Registration: NCT02318472 (ClinicalTrials.gov identifier).
Ocular Complications in the Prone Position in the Critical Care Setting: The COVID-19 Pandemic
Authors: Sanghi Priyanka , Malik Mohsan , Hossain Ibtesham T. , Manzouri Bita 
Published: September 2020

Purpose: Ocular complications are common in the critical care setting but are frequently missed due to the focus on life-saving organ support. The SARS-CoV-2 (COVID-19) pandemic has led to a surge in critical care capacity and prone positioning practices which may increase the risk of ocular complications. This article aims to review all ocular complications associated with prone positioning, with a focus on challenges posed by COVID-19. Materials and Methods: A literature review using keywords of “intensive care”, “critical care”, “eye care”, “ocular disorders”, “ophthalmic complications,” “coronavirus”, “COVID-19,” “prone” and “proning” was performed using the electronic databases of PUBMED, EMBASE and CINAHL. Results: The effects of prone positioning on improving respiratory outcomes in critically unwell patients are well established; however, there is a lack of literature regarding the effects of prone positioning on ocular complications in the critical care setting. Sight-threatening ophthalmic disorders potentiated by proning include ocular surface disease, acute angle closure, ischemic optic neuropathy, orbital compartment syndrome and vascular occlusions. Conclusions: COVID-19 patients may be more susceptible to ocular complications with increased proning practices and increasing demand on critical care staff. This review outlines these ocular complications with a focus on preventative and treatment measures to avoid devastating visual outcomes for the patient.
Refractory Dabigatran-Induced Hemorrhage Despite Multiple Idarucizumab Administration and Renal Replacement Therapy
Authors: Flynn Francis , Richard Guillaume , Dobrescu Marc A. , Bouchard Josée , Williamson David , Brindamour Dave , Charbonney Emmanuel , Dupuis Sébastien 
Published: September 2020

Purpose: This case report describes a patient with dabigatran accumulation due to acute kidney injury on chronic kidney disease, requiring multiple administration of idarucizumab along with renal replacement therapy because of rebound effect causing numerous episodes of bleeding. Summary: An 86-year-old man on dabigatran etexilate 110 mg twice daily for stroke prevention with atrial fibrillation was admitted to the hospital for bowel obstruction and severe acute kidney injury on chronic kidney disease. The patient had an abnormal coagulation profile and no history of bleeding. Initial laboratory values revealed a hemoglobin concentration of 10.7 g/dL, a platelet count of 115 × 103 platelets/μL, an activated partial thromboplastin time of 150.4 seconds, an international normalized ratio of 10.28, a thrombin time greater than 100 seconds and a serum creatinine of 5.54 mg/dL (490 μmol/L). An initial dose of idarucizumab was administered 1 hour prior to surgery to prevent bleeding. Significant bleeding and hemodynamic instability occurred following surgery. Three additional doses of idarucizumab, 2 sessions of intermittent hemodialysis, continuous venovenous hemofiltration and blood products were required to achieve normalization of coagulation parameters and hemodynamic stability due to rebound coagulopathy after each dose of idarucizumab. Conclusion: Acute kidney injury on chronic kidney disease and third-space redistribution could have led to important dabigatran accumulation and favored rebound coagulopathy. Multiple therapeutic approaches may be required in the management of complex dabigatran intoxication.