bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semantic processing event‐related potential features in patients with schizophrenia and bipolar disorder
Authors: Wang Kui , Zhao Yan‐li , Tan Shu‐ping , Zhang Jin‐guo , Li Dong , Chen Jing‐xu , Zhang Li‐gang , Yu Xin‐yang , Zhao Dan , Cheung Eric F. C. , Turetsky Bruce I. , Gur Ruben C. , Chan Raymond C. K. 
Published: December 2019

AbstractImpairment in semantic association has been reported in bipolar disorder (BD) and schizophrenia (SZ) patients and could underlie abnormal speech patterns in both disorders. In this study, we compared the electrophysiological semantic processing features in patients with these two disorders. Participants (n = 61; BD = 19; SZ = 19; healthy controls [HCs] = 23) were administered a semantic judgment task and event‐related potentials (ERPs) were recorded. Responses of the two patient groups were significantly slower than HCs, but comparable behavioral semantic priming effects were observed in both patient groups. The N400 priming effect was observed in all groups, with a delayed peak in the two patient groups. The N400 effect was enhanced for both BD and SZ patients over the left frontal and frontal pole region, but SZ patients showed additional reduction of N400 over the right posterior and occipital regions. The N400 mean amplitudes for related targets correlated with less severe negative symptoms in patients with SZ. Discriminant functional analysis using reaction time and N400 measures successfully classified 82% of the participants into their respective clinical groups. These results suggest that patients with BD and SZ have both overlapping and distinctive semantic processing dysfunction. These findings are consistent with the continuum conceptualization of these disorders, but also offer some support for the traditional Kraepelinian dichotomy.
Capacity Assessment of Prosthetic Performance for the Upper Limb (CAPPFUL): Characterization of Normative Kinematics and Performance
Authors: Boyle Alec , Prejean Brian , Ruhde Logan , Pool Kasey , Bollinger Christopher , Miguelez John , Conyers Dan , Ryan Tiffany , Kontson Kimberly L. 
Published: December 2019

BackgroundEvaluation of maladaptive compensatory movement is important to objectively identify the impact of prosthetic rehabilitative intervention on body mechanics. The Capacity Assessment of Prosthetic Performance for the Upper Limb (CAPPFUL) scores this type of compensation by comparing movements of the prosthesis user to movements of individuals with intact, sound upper limbs (ULs). However, expected movements of individuals with sound, intact ULs have not been studied for the set of tasks performed in the CAPPFUL.ObjectiveTo enhance the scoring approach for the maladaptive compensatory movement domain of the CAPPFUL by defining normative kinematic movement and characterizing variability and repeatability.DesignClinical measurement.SettingLaboratories at the U.S. Food and Drug Administration (FDA) and University of Texas‐Arlington.ParticipantsConvenience sample of 20 participants with no upper limb (UL) disability or impairment.InterventionsNot applicable.Main Outcome MeasurementsKinematic trajectories, range of motion, maximum angle, and completion time were calculated. Repeatability and intersubject variability were assessed by calculating Pearsonʼs correlation coefficient (R), adjusted coefficient of multiple correlation (CMCadj), and max SD (SDmax) for nine joint angles at the elbow, shoulder, neck, and torso.ResultsFor most joints evaluated, repeatability was lower (R < 0.8) for CAPPFUL 3‐Zip vest, CAPPFUL 7‐Cut w/ knife, and CAPPFUL 8‐Squeeze water, implying inconsistent approaches within a subject from trial to trial for a given task. For most tasks, the joint angle SDmax across all participants was <20°. The approach for completing CAPPFUL 1 ‐ Weights in crate and CAPPFUL 4 ‐ Pick up dice was generally similar across participants (CMCadj >0.4). For other tasks, however, different approaches across participants at the torso and shoulder joint can be seen.Conclusion(s)This work established the expected movements of individuals with sound, intact ULs for tasks performed in the CAPPFUL that can be used to inform consistent, standardized scoring of the maladaptive compensatory movement domain.
From migrant student to migrant employee: Three models of the school‐to‐work transition of mainland Chinese in Hong Kong
Authors: Peng Yinni 
Published: December 2019

AbstractAgainst the backdrop of the internationalisation of higher education and the increasing migration of young people in recent decades, how migrant students experience their school‐to‐work transition in host societies has become an important issue. Although the literature has explored the school‐to‐work transition of migrant students in higher education from a structural and an individual perspective, most studies have analysed this transition as a one‐time decision or focused on the migrant students' job‐hunting tactics. This study enriches the discussion of the intersection of youth transition and migration by discussing transition as a process of multiple and connected events, continuous experiences, and subjective interpretations. It demonstrates the diversity of the transition process in three models, proactive, challenging, and accommodative, and highlights the processual nature of transition with temporal, spatial, biographical, and emotional dimensions.
Monitoring recombinant protein expression in bacteria by rapid evaporative ionisation mass spectrometry
Authors: Sarsby Joscelyn , McLean Lynn , Harman Victoria M. , Beynon Robert J. 
Published: November 2019

RationaleThere is increasing interest in methods of direct analysis mass spectrometry that bypass complex sample preparation steps.MethodsOne of the most interesting new ionisation methods is rapid evaporative ionisation mass spectrometry (REIMS) in which samples are vapourised and the combustion products are subsequently ionised and analysed by mass spectrometry (Synapt G2si). The only sample preparation required is the recovery of a cell pellet from a culture that can be analysed immediately.ResultsWe demonstrate that REIMS can be used to monitor the expression of heterologous recombinant proteins in Escherichia coli. Clear segregation was achievable between bacteria harvesting plasmids that were strongly expressed and other cultures in which the plasmid did not result in the expression of large amounts of recombinant product.ConclusionsREIMS has considerable potential as a near‐instantaneous monitoring tool for protein production in a biotechnology environment.
Fault diagnosis and fault‐tolerant control based on Laplace transform for nonlinear networked control systems with random delay
Authors: Li Lifan , Yao Lina , Jin Haokun , Zhou Jinglin 
Published: December 2019

SummaryAiming at the problem of random delay for nonlinear networked control systems, a Laplace transform strategy is used to obtain the description of the random time‐delay block in the frequency domain in this paper and the equivalent system without delay can be obtained based on the output response expectation equivalent principle. Then, the fault diagnosis observer is designed to estimate the state and fault of the equivalent system simultaneously. The fault‐tolerant controller based on PI control algorithm and adaptive compensation is designed. Both the observer gain and fault tolerance controller gain are obtained by solving the linear matrix inequalities. Finally, the validity of the proposed method is verified by the simulation and experiment results.
Deferoxamine pretreatment inhibits metal neurotoxicity in Caenorhabditis elegans
Authors: Alves Carla , Zancan Natália Piva , Concato Ani Carla , Vanin Ana Paula , Tamagno Wagner A. , Tessaro Diego , Kaizer Rosilene R. 
Published: December 2019

AbstractNeurodegenerative diseases are increasingly common in humans. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of extracellular plaques containing β‐amyloid peptides and neurofibrillary tangles in the brains. Researchers have focused on the elucidation of a correlation between high concentrations of aluminum or iron (in the organism with observed neuropathology). The objective of this study was to evaluate the effects of aluminum and iron on the behavioral parameters (pharyngeal pumping and defecation cycle) of the nematode Caenorhabditis elegans pretreated with deferoxamine (DFX). Acetylcholinesterase (AChE) activity was evaluated as well. DFX is a chelant that is widely used for the treatment of metal toxicity, and it has a high affinity for aluminum and iron. The worms were pretreated with DFX, and then exposed to aluminum and iron. In the absence of DFX, aluminum exposure decreased pharyngeal pumping compared with that in the control group. The defecation cycle of the control was significantly different from that of the worms exposed to aluminum. In contrast, an increased defecation cycle was observed in worms exposed to iron without DFX pretreatment. AChE activity increased in aluminum‐exposed groups that received DFX pretreatment compared with those that did not receive pretreatment. These results suggest that pretreatment with DFX is effective in reducing metal toxicity, particularly with reference to AChE activity, which did not decrease in groups that did not receive DFX pretreatment.
Superconformal blocks for mixed 1/2-BPS correlators with SU(2) R-symmetry
Authors: Baume Florent , Fuchs Michael , Lawrie Craig 
Published: December 2019

Abstract
For SCFTs with an SU(2) R-symmetry, we determine the superconformal blocks that contribute to the four-point correlation function of a priori distinct half-BPS superconformal primaries as an expansion in terms of the relevant bosonic conformal blocks. This is achieved by using the superconformal Casimir equation and the superconformal Ward identity to fix the coefficients of the bosonic blocks uniquely in a dimension-independent way. In addition we find that many of the resulting coefficients are related through a web of linear transformations of the conformal data.
Streamlined mail-based methods for large randomised trials: lessons learnt from the ASCEND study
Authors: Mafham Marion M. , Bowman Louise J. , Haynes Richard J. , Armitage Jane M. 
Published: December 2019

AbstractReliable assessment of the effects of an intervention usually requires large randomised trials but such studies are becoming increasingly complex and costly to run. ‘Streamlined’ trials are needed in which every aspect of the trial design and conduct is simplified, retaining only those elements needed to answer the research question and ensure the safety of the individual participants. In this review we discuss how the trial ‘A Study of Cardiovascular Events iN Diabetes’ (ASCEND) was streamlined. The study included a two-by-two factorial design: it assessed the effects of low-dose aspirin and, separately, supplementation with n-3 fatty acids on serious vascular events in 15,480 people with diabetes but no overt cardiovascular disease. Other key streamlined design features, such as mail-based recruitment and follow-up, mainly by post, with no in-person visits and use of a run-in period, are also described. We go on to discuss the success of the study and other studies that have employed a similar mail-based approach, and the type of clinical trials that are suitable for mail-based design. Finally, we consider the limitations of the study, and how these could be circumvented in future studies. ASCEND randomised large numbers of eligible participants, achieved good adherence rates and almost complete follow-up at a fraction of the cost of traditional clinic-based trials. Such studies are necessary if researchers are to address the important clinical questions most relevant to improving health.
Nonlinear optimal moisture perturbations as excitation of primary MJO events in a hybrid coupled climate model
Authors: Wei Yuntao , Ren Hong-Li , Mu Mu , Fu Joshua-Xiouhua 
Published: December 2019

AbstractAlthough the moisture feedback has been well known to be essential in the Madden–Julian Oscillation (MJO) dynamics, whether its pre-moistening effect plays a key role in exciting the onset of primary MJO events, as has been confirmed in the successive initiation, remains elusive. In this study, using a hybrid coupled climate model that has a good fidelity in simulating the intraseasonal variability, we develop a new framework of methodology to investigate the nonlinear excitation of primary MJO event, of which the key achievement is the successful implementation of theconditional nonlinear optimal perturbation(CNOP). In an application of this new framework, the CNOP-type moisture perturbations are calculated for the pre-chosen non-MJO reference states and generally favor a moistening in the equatorial region while drying in the poleward. Comparisons of the model simulation with observation give credibility to the existence of moisture signals several weeks before some primary MJO events. A suite of numerical experiments confirms that the CNOPs of moisture can contribute to the excitation and propagation of strong primary MJO events while random perturbations cannot. The moisture budget analysis further reveals the central importance of the horizontal moisture advection, especially the nonlinearly upscaled moisture transports associated with the high-frequency disturbances on the quasi-3–4-day and 6–8-day synoptic time scales, in supporting the nonlinear excitation of the primary MJO events. The subgrid-scale processes of evaporation, condensation and eddy transport of moisture are found to be critical for the pre-moistening effect in the boundary layer as well. This study directly supports the vital importance of the moisture perturbations, which are characterized by a particular pattern concentrated at low levels, to the nonlinear growth and propagation of the primary MJO events.
One-year clinical outcomes in patients with renal insufficiency after contemporary PCI: data from a multicenter registry
Authors: Scholz Sean S. , Lauder Lucas , Ewen Sebastian , Kulenthiran Saarraaken , Marx Nikolaus , Sakhov Orazbek , Kauer Floris , Witkowski Adam , Vaglimigli Marco , Wijns William , Scheller Bruno , Böhm Michael , Mahfoud Felix 
Published: December 2019

AbstractBackgroundChronic kidney disease (CKD) is highly prevalent in patients with coronary artery disease (CAD).ObjectiveThe outcome following revascularization using contemporary technologies (new-generation abluminal sirolimus-eluting stents with thin struts) in patients with CKD (i.e., glomerular filtration rate of < 60 mL/min/1.73m2) and in patients with hemodialysis (HD) is unknown.Methodse-Ultimaster is a prospective, single-arm, multi-center registry with clinical follow-up at 3 months and 1 year.ResultsA total of 19,475 patients were enrolled, including 1466 patients with CKD, with 167 undergoing HD. Patients with CKD had a higher prevalence of overall comorbidities, multiple/small vessel disease (≤ 2.75 mm), bifurcation lesions, and more often left main artery treatments (allp < 0.0001) when compared with patients with normal renal function (reference). CKD patients had a higher risk of target lesion failure (unadjusted OR, 2.51 [95% CI 2.04–3.08]), target vessel failure (OR, 2.44 [95% CI 2.01–2.96]), patient-oriented composite end point (OR, 2.19 [95% CI 1.87–2.56]), and major adverse cardiovascular events (OR, 2.34 [95% CI 1.93–2.83,pfor all < 0.0001]) as reference. The rates of target lesion revascularization (OR, 1.17 [95% CI 0.79–1.73],p = 0.44) were not different. Bleeding complications were more frequently observed in CKD than in the reference (allp < 0.0001).ConclusionIn this worldwide registry, CKD patients presented with more comorbidities and more complex lesions when compared with the reference population. They experienced higher rate of adverse events at 1-year follow-up.Graphic abstract
Self-reported health problems in a health risk appraisal predict permanent work disability: a prospective cohort study of 22,023 employees from different sectors in Finland with up to 6-year follow-up
Authors: Pihlajamäki Minna , Uitti Jukka , Arola Heikki , Korhonen Mikko , Nummi Tapio , Taimela Simo 
Published: December 2019

Abstract
Purpose
Work disability (WD) as a medico-legal concept refers to disability benefits (DB) that are granted due to diseases that permanently reduce work ability. We studied whether an occupational healthcare instrument for the prediction of sickness absence (SA) risk—a health risk appraisal (HRA)—also predicts permanent WD.

Methods
HRA results were combined with registry data on DB of 22,023 employees from different industry sectors. We analysed how the HRA risk categories predict DB and considered occupational group, gender, age, and prior SA as confounding variables. Cumulative incidence function illustrates the difference between the HRA risk categories, and the Fine–Gray model estimates the predictors of WD during 6-year follow-up.

Results
The most common primary reasons for permanent WD were musculoskeletal (39%) and mental disorders (21%). Self-reported health problems in the HRA, labelled as “WD risk factors”, predicted DB when controlling for age and prior SA. Hazard ratios were 10.9 or over with the lower limit of the 95% confidence interval 3.3 or over among those with two simultaneous WD risk factors. 14% of the females and 17% of the males with three or more simultaneous WD risk factors had received a DB, whereas the respective figures among those without findings were 1.9% and 0.3%.

Conclusions
Self-reported health problems in the HRA, especially multiple simultaneous WD risk factors, predict permanent WD among both genders across occupational groups. Screening WD risk with a self-administered questionnaire is a potential means for identifying high-risk employees for targeting occupational healthcare actions.
Flip-Connectivity of Triangulations of the Product of a Tetrahedron and Simplex
Authors: Liu Gaku 
Published: December 2019

AbstractA flip is a minimal move between two triangulations of a polytope. The set of triangulations of a polytope was shown by Santos to not always be connected by flips, and it is an interesting problem to find large classes of polytopes for which it is. One such class which has received considerable attention is the product of two simplices. Santos proved that the set of triangulations of a product of two simplices is connected by flips when one of the simplices is a triangle. However, the author showed that it is not connected when one of the simplices is four-dimensional and the other has very large dimension. In this paper we show that it is connected when one of the simplices is a tetrahedron, thereby extending Santos’s result as far as possible.
Healthcare professionals’ perspectives of barriers and facilitators in implementing physical activity programmes delivered to cancer survivors in a shared-care model: a qualitative study
Authors: IJsbrandy Charlotte , van Harten Wim H. , Gerritsen Winald R. , Hermens Rosella P.M.G. , Ottevanger Petronella B. 
Published: December 2019

Abstract
Background
The positive impact of physical activity programmes has been recognised, but the current uptake is low. Authorities believe delivering these programmes in a shared-care model is a future perspective. The present study aimed to identify the barriers and facilitators affecting physical activity programme implementation in a shared-care model delivered with the cooperation of all the types of healthcare professionals involved.

Methods
Thirty-one individual interviews with primary healthcare professionals (PHPs) and four focus group interviews with 39 secondary healthcare professionals (SHPs) were undertaken. We used Grol and Flottorp’s theoretical models to identify barriers and facilitators in six domains: (1) physical activity programmes, (2) patients, (3) healthcare professionals, (4) social setting, (5) organisation and (6) law and governance.

Results
In the domain of physical activity programmes, those physical activity programmes that were non-tailored to the patients’ needs impeded successful implementation. In the domain of healthcare professionals, the knowledge and skills pertaining to physical activity programmes and non-commitment of healthcare professionals impeded implementation. HCPs expressed their concerns about the negative influence of the patient’s social network. Most barriers occurred in the domain of organisation. The PHPs and SHPs raised concerns about ineffective collaboration and networks between hospitals. Only the PHPs raised concerns about poor communication, indeterminate roles, and lack of collaboration with SHPs. Insufficient and unclear insurance coverage of physical activity programmes was a barrier in the domain of law and governance.

Conclusions
Improving the domain of organisation seems the most challenging because the collaboration, communication, networks, and interactive roles between the PHPs and SHPs are all inadequate. Survivor care plans, more use of health information technology, improved rehabilitation guidelines, and better networks might benefit implementing physical activity programmes.
Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review
Authors: Verhaak Eline , Gehring Karin , Hanssens Patrick E. J. , Aaronson Neil K. , Sitskoorn Margriet M. 
Published: December 2019

AbstractPurposeA growing number of patients with brain metastases (BM) are being treated with stereotactic radiosurgery (SRS), and the importance of evaluating the impact of SRS on the health-related quality of life (HRQoL) in these patients has been increasingly acknowledged. This systematic review summarizes the current knowledge about the HRQoL of patients with BM after SRS.MethodsWe searched EMBASE, Medline Ovid, Web-of-Science, the Cochrane Database, PsycINFO Ovid, and Google Scholar up to November 15, 2018. Studies in patients with BM in which HRQoL was assessed before and after SRS and analyzed over time were included. Studies including populations of several types of brain cancer and/or several types of treatments were included if the results for patients with BM and treatment with SRS alone were described separately.ResultsOut of 3638 published articles, 9 studies met the eligibility criteria and were included. In 4 out of 7 studies on group results, overall HRQoL of patients with BM remained stable after SRS. In small study samples of longer-term survivors, overall HRQoL remained stable up to 12 months post-SRS. Contradictory results were reported for physical and general/global HRQoL, which might be explained by the different questionnaires that were used.ConclusionsIn general, SRS does not have significant negative effects on patients’ overall HRQoL over time. Future research is needed to analyze different aspects of HRQoL, differences in individual changes in HRQoL after SRS, and factors that influence these changes. These studies should take into account several methodological issues as discussed in this review.