bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approval of the method of modeling of regenerating systems by the example of modeling the process of functioning of the information system taking into account service of various types of applications
Authors: Zamoryonov M V , Kopp V Y , Zamoryonova D V 
Published: July 2020

Abstract
The article verifies the method of modeling regenerative systems with a common phase state space using the example of phase enlargement of the model of the information system functioning process taking into account the servicing of various types of applications. The distribution functions of random variables obtained using the method proposed in this work, based on the theorem on the distribution functions of the residence time in a subset of continuous states, and obtained using the classical phase enlargement algorithm, are compared, and the transition probabilities of the enlarged system and the stationary distribution of the embedded circuit are determined and compared Markov. It shows the coincidence of the results of phase enlargement carried out by the method proposed in the work and the classical algorithm of phase enlargement. This work clearly demonstrates the simplicity and convenience of the proposed method of phase enlargement due to the fact that there is no need to determine the stationary distribution of the embedded Markov chain for systems with a common phase state space, which is a rather complicated task that requires solving systems of integral equations containing sums and differences of variables. Currently, a general solution to this problem is unknown, although there are solutions for individual cases.
Choice of materials and justification of the parameters for the over-bit hammer
Authors: Iungemeister D A , Korolev R I , Yacheikin A I , Isaev A I 
Published: July 2020

Abstract
Currently, there is a lack of efficiency of intensification of the rotational drilling process. Therefore, it is proposed to amplify it with shock loads by installing a downhole hammer (DH) into the rig’s drilling assembly, for instance, SBSh-250. In addition, the PPU changes the impact system by placing between the piston-striker and the drilling tool, an intermediate element of smaller mass and size – the striker made of a special Al-Ti alloy. At the same time, it is assumed that the drilling tool will be reinforced with tungsten carbide WC and other high-strength materials. Besides the SBSh-250 machines, shock loads can be applied to disk cones used in tunneling complexes. In this case, the oscillation generator should be placed together with the disk roller cutter into the body of the rotary actuator. The article also discusses the issue related to the choice of bearing material operating under high shock loads. The proposed constructions of rock-cutting tools are calculated in the process of experimental studies in a manner that the increased impact energy does not influence the durability of the working tool and the elements of the DH impact system (selection of high-strength material for making the striker). Having selected the necessary parameters using a test stand, the improved drilling system will allow one to increase the drilling speed (productivity) by 20–30 %, to increase the speed of tunneling with the installed vibroactive disk rolling-cutter by 25 %, and also to extend the operational life of the working tool.
Flood susceptibility mapping in densely populated urban areas using MCDM and fuzzy techniques
Authors: Nourani Vahid , Andaryani Soghra 
Published: July 2020

Abstract
Flood, as the most destructive natural phenomenon in Iran, causes a multitude of deaths and financial losses every year in different parts of the country. This study sought to determine flood-prone areas in one of the Ajay River sub-basins (Lighvan River basin), Iran using Analysis Hierarchy Procedure (AHP) for ranking, fuzzy logic (FZ) for integrating with AHP in order to rank and Weighted Linear Combination (WLC) for the combination of maps. For this purpose, the geomorphologic and hydrologic factors affecting the occurrence of floods such as slope, distance from the river, Hydrological Soil Group (HSG), Curve Number (CN), runoff, lithology, land use, drainage density, Gravilius coefficient in each of the 23 sub-basins were considered based on the literature. The desired criteria and sub-criteria were weighted by the AHP and FZ, respectively. Then, WLC aggregation method was applied to generate the flood susceptibility map in five classes. The results earned by the combination of Multi-Criteria Decision Analysis (AHP and WLC)-FZ (MCDM-FZ) show that 28% of the area is in high and very high hazard classes that these areas are located almost at the entrance of Tabriz city, which is a densely populated urban area. Basic measured need to be taken in the upstream of the basin especially in areas with the high flood zone.
Application of organic fertilizer on swamps pond for catfish (Pangasius sp.) culture
Authors: Jubaedah D , Sasanti A D , Marsi  , Mukhlas M A 
Published: July 2020

Abstract
Swamp fish pond has a problems related to submerged flat soil and water pH value and result in low productivity of ponds. Fertilization increase productivity of pond water by providing nutrients for fish food organisms, The objective of this research was to determine the best dosage of organic fertilizer to improve water quality and pond productivity and it’s effect to survival and absolute growth of catfish Pangasius sp. The research was conducted with using completely randomized design with four treatments and three replications. All of ponds unit were limed using dolomite of 10 ton/ha, incubated for 13 days, then gave four difference dosage of organic fertilizer, that were without fertilizer (P0), with fertilizer of 100 g/m2 (P1), 170 g/m2 (P2), and 240 g/m2 (P3). Pangasius sp. fish (average body length of 5±0.5 cm) was stocked with the density of 15 fish/m2 and cultured for 30 days. The parameters observed were soil (pH, N, P2O5, Ca, and C-organic) and water quality (pH, alkalinity, temperature, dissolved oxygen, ammonia, total Phosphate, Ca, and TOC), pond productivity, density of phytoplankton, survival, absolute growth, feed efficiency, and production of fish. The data were statistically analyzed by one-way ANOVA, Least Significant Difference test, and regression models analysis. The results showed that P1 (100 g/m2 of fertilizer) was the best dosage indicated by pH 7.60, nitrogen 0.13%, P2O5 0.16%, Ca 2.59%, C-organic 1.49% of pond soil; pH 7.42, temperature 27.3-32.4°C, dissolved oxygen 4.94-5.09 mgL−1, alkalinity 51.33 mgL−1, Ca 55 mgL−1,TOC 12.3 mgL−1, ammonia 0.24 mgL−1, Total Nitrogen (TN) 3.78 mgL−1, Total Phosphate (TP) 0.109 mgL−1 of pond water. Based on TN:TP (10.09) of water showed nutrient was balanced. Productivity of ponds was on eutrophic state based on both TN and TP. Survival rate of catfish was 100%, absolute gain of weight 8.46 g and lenght 3.99 cm, Feed efficiency of fish was 101.55% and the density of phytoplankton was 217 cell/mL.
Salt farmer’s adaptation strategy facing climate change (case study in Pati Regency)
Authors: Kurniawan T , Zulham A 
Published: July 2020

Abstract
Climates change impact on salt productions in Pati Regency. The salt farmer usually only shifts to aquaculture in the rainy season. Thus, while the climate becomes unpredictable, they adapted to extreme weather conditions. However, changes in weather such as dryer summers, rain in summer, more extended summer season, longer rainy season, and high tides. It made the salt production decrease. Salt farmer have their adaptation strategies during climate change. This research aims to analyze reasons for adaptation strategies regarding climate change. The research conducted in Pati Regency from 2011 to 2016. Pati Regency is the 3rd most significant salt production area in Indonesia. We interviewed the respondents, as well as confirmed the data to other farmers, extension officers, and agency officers in the district. The data used in this paper are the salt farmer perception is regarding climate change and their adaptation strategies. We also used content analysis to strengthen our data based on literature and other founding. We found that Salt farmers use their strategy to fasten production, such as using canvas, black stone, LDPE (Low-Density Poly Ethylene), and HDPE (High-Density Poly Ethylene). LDPE and HDPE were introduced by Ministry Marine Affairs and Fisheries (MMAF) in 2013 and turned out to be very helpful for the farmers. The technology introduced by MMAF increased production by 14% and price by 144% than before while working loads become lighter, especially in the harvesting process. Several adaptation strategies have implemented in other Regencies, such as MMAF technology. However, it still needs continuous persuasion because not all farmers wanted to apply it.
Increasing productivity of snakehead fish (Channa striata) juvenile in ponds with different bottom substrates
Authors: Widyastuti Y R , Prihadi T H , Taufik I , Pamungkas B A , Das S K 
Published: July 2020

Abstract
Low production of striped snakehead juvenile in ponds is due to the difference between pond and their natural habitat. Bottom substrate might probably a factor influencing the growth performance of striped snakehead juvenile. The purpose of this research was to determine the best bottom substrate to increase growth performance of striped snakehead juvenile reared in ponds. A randomized design consisted of three treatments of bottom substrates, sand, mud, no substrate as control, with three replications were used in the present study. Striped snakehead juvenile sized 6.1±0.05 cm and 2.11±0.07 g were in a 3 × 2 × 1 m plastic line pond, with 30 cm depth water. The density of fish were 20 fish per m3 and juveniles reared for 60 days. The result showed that juvenile reared with sand substrate had better survival rate and blood glucose (P<0.05) than other treatments. The substrate treatments, sand and mud, were also better in absolute length, absolute weight, specific growth rate, than no substrate one (control). In contrast, control was better than substrates treatments (sand and mud) in feed efficiency. Overall data indicated that sand substrate is a supporting environment for growing out juvenile of snakehead fish.
A case study on mortality of neon tetra (Paracheirodon innesi) associated with the seasonal climate transitions in West Java – Indonesia
Authors: Sugiani D , Purwaningsih U , Gardenia L , Mufidah T , Nafiqoh N , Aryati Y , Sumiati T , Andriyanto S , Taukhid  , Lusiastuti A M , Caruso D 
Published: July 2020

Abstract
This study aimed to identify pathological agent and determine the impact of water quality during climate transitions on mass mortalities of neon tetra (Paracheirodon innesi) in the West Java region of Indonesia. Ten thousand fishes reported died each day during the seasonal. Samples of 10 fish/tank were taken and tested for parasites, fungal, and bacteria. The investigations tests showed that the primary disease was caused by parasite from protozoa Pleistophora spp. (Microsporidia). It was confirmed by taxonomic descriptions and histopathological diagnosis. This parasite causes histozoic infection. Fungus was not detected, and bacteria were identified as Aeromonas sp. and Pseudomonas sp.. The water temperature fluctuation was recorded higher than 7°C between daylight and night. Mortality was recorded in every size of fish. The clinical signs of fish on the outbreak were pale body, discoloration of the lateral line, the appearance of white patches under the skin, lethargy, swimming disorder, and losing weight. The recommendations due to the outbreaks were total eradication for infected fish populations, separating newly arrived fish (quarantine) at least 2 weeks, maintaining water quality in the optimal range, and proper cleaning (sanitizing) must be performed.
Controlling gonad maturation on snakehead (Channa striata, Bloch 1793) for eliminating impact of climate change
Authors: Gustiano R , Ath-thar M H F , Kristanto A H , Prakoso V A , Kusmini I I , Saputra A 
Published: July 2020

Abstract
The consequences of climate change, in general, are changes in temperature and extreme season. Related to the fish gonad maturation, the effect of temperature can be distinguished by its effect on fish depending on the pattern of the reproduction and spawning season. In fish that spawn seasonally, rising temperatures in the tropical area signal the fish to ripen the gonads and migrate to the spawning area for ovulation in the early spawning season. Therefore, changing in the beginning and its duration of the season related to climate change will affect the maturity of fish gonads. In this paper communication, controlling gonad maturation on snakehead for eliminating impact of climate change is discussed. Observation of the gonad development on thirty mature snakehead stocks in Bogor, West Java, was conducted every month during a year. The obtained data were then compared to a similar previous study in the same area to have better insight on the impact of climate change on gonad development. To eliminate natural signal influence on the snakehead spawning, the study of gonad maturation in spawning (August to January) and out spawning season (February to July) using combination hormone of Pregnant Mare Serum Gonad (PMSG) and Anti Dopamine (AD) was done. The study used three breeders for each season, the dosage hormone of 2 mL/kg body weight was injected every month when the eggs were starting to develop, from September to November for spawning season and from May to July for out spawning season. The observed parameters were eggs diameter, fecundity, estradiol concentration, and gonadosomatic index. The results showed that reproductive performance tends to decline and fluctuate compared to the previous study done two years earlier. The highest eggs diameter, fecundity, and gonadosomatic index were in November. Hormone treatments in spawning and out spawning season were not significantly different (P>0.05) in the eggs diameter. The concentration of estradiol in the spawning season were higher than out spawning season, but they were not significantly different (P>0.05). Thus, hormone induction out the spawning season enabled to enhance breeder maturation as in the spawning season. Based on the result, hormone treatment could be used as an alternative to control maturation on the snakehead breeders from the impact of climate change.
Evolution of structural and magnetic properties in iron oxide nanoparticles synthesized using Azadirachta indica leaf extract
Authors: Kanase R S , Karade V C , Kollu P , Sahoo Subasa C , Patil P S , Kang S H , Kim J H , Nimbalkar M S , Patil P B 
Published: July 2020

Abstract
The novel superparamagnetic nature of magnetic nanoparticles (MNPs) has received significant attention in the wide variety of fields. However, the prerequisites to use these MNPs, particularly in biomedical applications are biocompatibility and high saturation magnetization (Ms). Thus, the development of a sustainable approach for the synthesis of biocompatible MNPs, which utilizes the redox properties of natural compounds from plant extracts, is highly desired. Herein, we have examined the growth of phase selective MNPs synthesized using Azadirachta indica (Neem) extract as a reducing and capping agent. The physical and biological properties of MNPs synthesized with the modified green hydrothermal method at different reaction times and temperatures were investigated. It was observed that the reaction time and temperature strongly modulated the magnetic and structural characteristics of MNPs. At lower reaction time and temperature of 200 °C for 2 h, primarily iron oxalate hydrate (Fe(C2O4).2(H2O)) was formed. Further, with increasing reaction temperature, the phase transformation from iron oxalate hydrate to pure magnetite (Fe3O4) phase was observed. The MNPs prepared with optimum conditions of 220 °C for 4 h show superparamagnetic nature with improved Ms value of 58 emu g−1. The antibacterial study of MNPs against gram-positive bacteria Staphylococcus aureus showed that the MNPs inhibits the growth of bacteria with the least inhibitory MNPs concentration of 6 μl. Thus, the MNPs obtained by this modified biogenic approach will widen the scope and their applicability in future biomedical applications.
An information-theoretic approach for measuring the distance of organ tissue samples using their transcriptomic signatures
Authors: Manatakis Dimitris V , VanDevender Aaron , Manolakos Elias S 
Published: July 2020

Abstract

Motivation
Recapitulating aspects of human organ functions using in vitro (e.g. plates, transwells, etc.), in vivo (e.g. mouse, rat, etc.), or ex vivo (e.g. organ chips, 3D systems, etc.) organ models is of paramount importance for drug discovery and precision medicine. It will allow us to identify potential side effects and test the effectiveness of new therapeutic approaches early in their design phase, and will inform the development of better disease models. Developing mathematical methods to reliably compare the ‘distance/similarity’ of organ models from/to the real human organ they represent is an understudied problem with important applications in biomedicine and tissue engineering.

Results
We introduce the Transcriptomic Signature Distance (TSD), an information-theoretic distance for assessing the transcriptomic similarity of two tissue samples, or two groups of tissue samples. In developing TSD, we are leveraging next-generation sequencing data as well as information retrieved from well-curated databases providing signature gene sets characteristic for human organs. We present the justification and mathematical development of the new distance and demonstrate its effectiveness and advantages in different scenarios of practical importance using several publicly available RNA-seq datasets.

Availability and Implementation
The computation of both TSD versions (simple and weighted) has been implemented in R and can be downloaded from https://github.com/Cod3B3nd3R/Transcriptomic-Signature-Distance.

Contact
dimitris.manatakis@emulatebio.com

Supplementary information
Supplementary data are available at Bioinformatics online.
Long-term impact of the burden of new-onset atrial fibrillation in patients with acute myocardial infarction: results from the NOAFCAMI-SH registry
Authors: Luo Jiachen , Xu Siling , Li Hongqiang , Gong Mengmeng , Li Zhiqiang , Liu Baoxin , Qin Xiaoming , Shi Beibei , Wei Yidong 
Published: July 2020

Abstract

Aims
We aimed to investigate the prognostic impact of the burden of new-onset atrial fibrillation (NOAF) on long-term cardiovascular outcomes in patients with acute myocardial infarction (AMI).

Methods and results
This retrospective analysis consecutively included patients without a documented atrial fibrillation (AF) history who admitted for AMI at Shanghai Tenth People’s Hospital between February 2014 and March 2018. Atrial fibrillation burden was measured as the percentage of time spent in AF, and its optimal cut-off value of 10.87% was identified by X-tile software. Of 2399 patients (mean age: 65.8 years, 76.6% of men), 278 (11.6%) developed NOAF during hospitalization. During a median follow-up of 2.7 years, the incidence of all-cause death was 3.19, 9.00, and 17.41 per 100 person-years in the sinus rhythm (SR), low-burden (AF burden ≤ 10.87%), and high-burden (AF burden &gt; 10.87%) groups, respectively. After adjustment for confounders, it was the high-burden NOAF [hazard ratio (HR): 1.94, 95% confidence interval (CI): 1.28–2.95] rather than the low-burden one (HR: 1.47, 95% CI: 0.97–2.21) that was significantly associated with increased mortality compared with SR. Concordant results were obtained in our propensity score-matched analyses [2.55 (1.57–4.16) and 1.32 (0.85–2.05) for high- and low-burden NOAF, respectively). In addition, post-myocardial infarction NOAF was associated with an increased risk of heart failure irrespective of its burden. Only those high-burden individuals were at heightened risk of ischaemic stroke. The restricted cubic spline curves illustrated a dose-response relationship of NOAF burden with outcomes.

Conclusion
In patients with NOAF complicating AMI, high AF burden was strongly associated with long-term outcomes.
Leukocytospermia is not an informative predictor of positive semen culture in infertile men: results from a validation study of available guidelines
Authors: Ventimiglia Eugenio , Capogrosso Paolo , Boeri Luca , Cazzaniga Walter , Matloob Rayan , Pozzi Edoardo , Chierigo Francesco , Abbate Costantino , Viganò Paola , Montorsi Francesco , Salonia Andrea 
Published: July 2020

Abstract

STUDY QUESTION
Are the European Association of Urology (EAU) guidelines for performing semen culture accurate enough for detecting a positive semen culture in Caucasian-European infertile men?

SUMMARY ANSWER
The majority (80%) of asymptomatic infertile men with a positive sperm culture may miss a proper diagnostic assessment when relying on EAU guidelines; no single parameter can assist in medical decision-making.

WHAT IS KNOWN ALREADY
The EAU guidelines suggest performing semen culture in case of increased leukocytes in semen (&gt;106 peroxidase positive white blood cells/ml, i.e. leukocytospermia).

STUDY DESIGN, SIZE, DURATION
A cross-sectional validation study including 523 infertile men was carried out during 2010–2018.

PARTICIPANTS/MATERIALS, SETTING, METHODS
Infertile men who were asymptomatic for genital infections were enrolled at a single academic center, and a semen culture was obtained in every case. A concentration of &gt;103 cfu/ml urinary tract pathogens in the ejaculate was considered indicative of significant bacteriospermia. Semen analysis values were assessed on the basis of 2010 World Health Organization reference criteria. EAU guidelines for semen culture were used to predict positive semen culture in our cohort and thus validated. Moreover, we tested the predictive performance and accuracy of several clinical parameters and compared them to EAU guidelines.

MAIN RESULTS AND THE ROLE OF CHANCE
A positive semen culture was found in 54 men (10%). The application of EAU guidelines would have missed 43 out of 54 (80%) positive semen cultures with 120/131 (92%) useless examinations. EAU guidelines specificity, sensitivity and discrimination were 74%, 20% and 47%, respectively. When trying to improve positive semen culture prediction, we were unable to find any informative baseline parameter except for serum neutrophil-to-lymphocyte ratio (odds ratio 1.70 (95% CI 1.04–2.77)), although without any improvement in terms of discrimination (P = 0.10).

LIMITATIONS, REASONS FOR CAUTION
The study was limited by the lack of a control group of fertile men its retrospective nature. Moreover, monoclonal antibodies were not used for leukocyte assessment.

WIDER IMPLICATIONS OF THE FINDINGS
Since it is not possible to identify infertile men at risk of semen infection, further studies are needed to tailor the execution of semen culture.

STUDY FUNDING/COMPETING INTEREST(S)
No funding was received for this study. There are no competing interests.