bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for postpartum sepsis: A nested case control study
Authors: Bakhtawar Samina , Sheikh Sana , Qureshi Rahat , Hoodbhoy Zahra , Payne Beth , Azam Iqbal , Dadelszen Peter van 
Published: January 2020

Abstract
Background: Majority (99%) of maternal deaths occur in low and middle income countries. The three most important causes of maternal deaths in these regions are postpartum hemorrhage, pre-eclampsia and puerperal sepsis. There are several diagnostic criteria used to identify sepsis and one of the commonly used criterion is systematic inflammatory response syndrome (SIRS). However, these criteria require laboratory investigations which may not be feasible in resource constrained settings. Therefore, this study aimed to develop a model based on risk factors and clinical signs and symptoms that can identify sepsis early among postpartum women.Methods: A case control study was nested in an ongoing cohort of 4000 postpartum women who delivered or were admitted in study hospital. According to standard criteria of SIRS, 100 women with sepsis (cases) and 498 women without sepsis (controls) were recruited from January to July 2017. Information related to socio-demographic status, antenatal care and maternal life styles were obtained via interview while pregnancy and delivery related information, comorbid and clinical sign and symptoms were retrieved from ongoing cohort. Multivariable logistic regression was performed and discriminative performance of the model was assessed using area under the curve (AUC) of the receiver operating characteristic (ROC).Results: Multivariable analysis revealed that 1-4 antenatal visits (95% CI 0.01 - 0.62), 3 or more vaginal examinations (95% CI 1.21 - 3.65), home delivery (95% CI 1.72-50.02), preterm delivery, diabetes in pregnancy (95% CI 1.93-20.23), lower abdominal pain (95% CI 1.15 - 3.42)) vaginal discharge (95% CI 2.97-20.21), SpO2 <93% (95% CI 4.80-37.10) and blood glucose were significantly associated with sepsis. AUC was 0.84 (95% C.I 0.80-0.89) which indicated that risk factors and clinical sign and symptoms based model has adequate ability to discriminate women with and without sepsis.Conclusion: This study developed a non-invasive tool which can identify postpartum women with sepsis as accurately as SIRS criteria with good discriminative ability. Once validated, this tool has a potential to be scaled up for community use by frontline health care workers.
Research of Network Closed-loop Control System Based on the Model Predictive Control
Authors: Shuping Xu , Shuang Wang , yu Guo , Xiaohui Su 
Published: January 2020

Abstract
Uncertainty latency of the remote closed-loop control system in information transmission through Internet, Analysis delays how to influence closed-loop control system. Based on predictive control method of neural network, research the application of closed-loop control system control methods under a random network delay. Simulation results show that: This method is able to reflect and predict the delay characteristics of between network path represented by the measured data, and can be replace actual network to research in application based on Internet closed-loop control system; the methods used is fast and accurate, it can be used for online learning network model and predict the network delay value, provides a new way of remote closed-loop control based on Internet.
Design and Research of Future Network (IPV9) API
Authors: Yinqiu Xu , Jianping Xie 
Published: January 2020

Abstract
Socket is a way of process communication, that is used it to invoke some API function to realize the distribution network libraries in different host of data exchange between the relevant process. According to the TCP/IP protocol assigned to the network address of the local host, to communicate between the two processes, the host must know the other’s location first, that is, the IP of the other host. At the same time, to get the port number, it is used to identify the local communication process; a local process in communication will occupy a port number, different process port number is different, so it must be assigned a port number that is not used before communication. A complete inter-network process consists of two processes and should use the same high-level protocol. IPV9 is the most important part of future network. This paper introduces the interface function and socket of IPV9, which lays a foundation for further network application programming.
On the RFID Information Query Technology Based on IPV9
Authors: Guiping Li , Lei Xue 
Published: January 2020

Abstract
Since coding format of RF label is inconsistent with the protocol format of the information server’s network, a design scheme of network architecture is proposed to achieve the connectivity between the decimal network based on IPV9 and the Internet network based on IPV4/IPV6. And also, two ways of information’s Query and connectivity based on D-ONS and direct routing between the decimal network is devised by using the expert modules. The experiment results shows that both the two ways can provide efficient service of RFID Information Query.
Target Characterization Using MIMO Radar
Authors: Nath Sur Samarendra , Bera Soumyasree , Shome Subhankar , Bera Rabindranath , Maji Bansibadan 
Published: January 2020

Abstract
The exploitation of coherency gain and diversity gain to improve the MIMO system performance is a burning research topic. This paper is to examine the performance analysis of MIMO radar by utilizing the above-said gains. The authors have analyzed the performance of the MIMO radar, in terms of mathematical modeling, considering the probability of detection and post-processing SNR, with respect to changes in the diversity order. Furthermore, this paper also deals with the practical implementation and analysis of the said system, demonstrating the range imaging and RCS pattern of a known standard target.
Traditional and Conventional Social Communication Processes for Increasing Tolerance and Harmonization of Inter-Religious Communities in Indonesia
Authors: Aras Muhammad , Gunawan Alexander A. S. 
Published: January 2020

This research focused on the social communication process for increasing tolerance and harmonization of inter-religious communities in Indonesia. This research method used the case study design. Research data of this case study were collected through observations and in-depth interviews. The results indicate that the process of social communication between religions takes place dynamically in the community. It involves mutual interactions and respect for each other according to social norms and values adopted by the local community. By interacting and respecting each other, the social life of the community can be maintained to be harmonious, safe, comfortable, full of tolerance and harmony, and coexist in religious, cultural, ethnic, racial, and ethnic diversity. Based on research findings, all can be done through the social communication process for increasing tolerance and harmonization of social life among religious communities in Indonesia that the process of social communication is directly referred to as traditional and conventional communication.
Effectiveness of drugs with delayed-release structurally modified action depending on the phenotype of osteoarthritis
Authors: Kabalyk M. A. 
Published: January 2020

Aim. To evaluate the effectiveness of a fixed combination of honadroitin and glucosamine sulfate (Teraflex, Bayer) in the treatment of osteoarthritis (OA), depending on the molecular phenotype of the disease.Materials and methods. A 6-month prospective, open, randomized trial included 65 patients with OA of the knee joints who were prescribed therapy with Teraflex (Bayer) daily dose of 1500 mg + 1200 mg. Kinetic assessment of articular status was performed using a visual analogue pain scale and a WOMAC questionnaire, and serum concentrations of CRTAP (cartilage-associated protein), OSGIN-1 (oxidative stress-induced growth inhibitor 1), IL-1β (interleukin-1 beta) were determined in blood serum. Measurements of these parameters were made at the beginning of the study, after 3 and 6 months.Results. It was established that the rate of onset of the therapeutic effect and the effect on the molecular patterns of inflammation and oxidative stress depend on the phenotype of the disease. So, with oxidative and mixed phenotypes of the disease, clinical efficacy is observed in the treatment of teraflex after 3 months from the start of therapy. Indicators of oxidative stress during treatment decreased in the group of patients with the oxidative phenotype of the disease, while the level of interleukin-1 significantly decreased only in groups of patients with inflammatory and mixed OA phenotypes.Conclusions. The results indicate the effectiveness and safety of the drug Teraflex (Bayer) for the treatment of patients with OA. The results of the study indicate the targeted effect of a fixed combination of chondroitin + glucosamine on the molecular mechanisms of the disease.
A comparative study of the bacteriotropic effect of metabiotics
Authors: Neschislyaev V. A. , Fedorova T. V. , Sorokina Yu. V. , Molokhova E. I. , Savina A. S. 
Published: January 2020

Objective of the study:comparative evaluation of the bacteriotropic activity of Actoflor-S metabiotic and the exometabolic bifidobacteria complex.Materials and methods:in our work we used Actoflor-S dietary supplement as oral solution in 2 ml drop tubes (Solopharm). As a comparator drug, we used an exometabolite complex from the culture fluid of strain Bifidobacterium bifidum 1 obtained by method of ultrafiltration using separation apparatus with HOMM 15 kDa. We studied the stimulating effect of metabolite compositions on the acid forming activity and dynamics of the accumulation of lactobacilli Lactobacillus plantarum 8P-A3. Antagonistic activity against enterobacteria was determined in the test of inhibition of bioluminescence of the indicator strain Escherichia coli lum+ and quantified as an index of antibacterial activityResults and discussions.A comparative study of the effects of metabiotics on the acid forming activity of lactobacilli showed that both drugs have a pronounced stimulating effect on the probiotic strain L. plantarum. A comparative study of the effects of metabiotics on the model test strain of enterobacteria showed that whole preparations quickly and significantly (by more than 90%) inhibit the bioluminescence of E.coli lum+. Preparation dilutions 1:10 and 1:100 discovered significant differences in their activity. Given equal pH values (5.8 ± 0.1), Actoflor-S (dilution 1:10) inhibited the luminescence of E. coli lum + to a greater degree, exceeding almost 2 times the indicators of the metabolite bifidobacteria complex. It is revealing that Actoflor-S diluted 1:10 is not inferior to the whole preparation in terms of the level of effect on the test strain culture. What calls attention to itself is that large dilutions of UFLC of bifidobacteria after a short period of inhibition of luminescence of E. coli lum + have a stimulating effect. There is evidence that effect of inhibition of the luminescence of the control culture is dose-dependent.Conclusion.The results of a comparative examination of the bacterial action profile of the native exometabolites complex and Actoflor-S preparation confirm the presence of combination of the necessary inhibitory and stimulating activity against various agents of the microbiota. Creation of the metabiotics line based on Actoflor-S preparation with variability of biological properties and specialized for the management of various dysbiotic conditions show promise. An additional inclusion of native exometabolites of bifidobacteria and/or lactobacilli into the formula of artificial compositions will make it possible to expand the spectrum of the positive effect of probiotic preparations on the microorganism.
Optimization of long-term prognosis of patients with alcoholic liver disease
Authors: Lunkov V. D. , Maevskaya M. V. , Ivashkin V. T. 
Published: January 2020

Aim: to prove the effectiveness of combined physical and psychological assessment in improving the long-term outcome of patients with alcoholic liver disease (ALD).Materials and methods: the active outpatient follow-up (AOF) group included 29 patients with ALD consisted of active liver function and motivation assessment, motivational interviewing, liver panel lab tests with the rate once at 3 months. The AOF program consisted of dynamic monitoring of liver function at least 1 time in 3 months and psychological support provided by the hepatologist using brief interventional approach. The control of abstinence was provided by using self-reports and indirect biomarkers of alcohol consumption. The control group included 36 patients with ALD and history of two-years follow-up after first alcoholinduced liver injury who received comprehensive therapy and a simple advice to avoid alcohol.Results: the adherence to abstinence were significantly higher in AOF group compared with control group. The proportion of patients with decompensated cirrhosis was significantly lower in AOF group compared with control group at 12 and 24 months after enrollment. The long-term survival in AOF-group was significantly higher than in control group. The only parameter independently associated with long-term survival was the presence of AOF program.Conclusion: the combined physical and psychological assessment of patients with ALD, provided by internists improves adherence to abstinence, reduces the risk of decompensation of liver function, severity of ALD and improves patients survival in the long term period.
Experience of patient preparation for colonoscopy and colonic surgery with sodium phosphate
Authors: Katorkin S. E. , Andreev P. S. , Berezkina S. Yu. , Davydova O. E. 
Published: January 2020

The article presents the experience of using sodium phosphate in patients, who were treated at the Clinic of Hospital Surgery of the Samara State Medical University Clinics in 2019.Purpose of the study: evaluate the quality of patient preparation for colonoscopy with sodium phosphate in surgical hospital environment. Material and methods. A total of 50 patients who were admitted for emergency indications to the Clinic of Hospital Surgery in 2019 were enrolled in the study. All patients were divided into two groups.The study included patients aged 24 to 69 years. The median age was 55.1 years in the treatment group and 56.2 years in the control group (p = 0.06). Men predominated in both groups: 16 (64%) in group 1 and 18 (72%) in group 2 (p = 0.08). The average time for submitting complaints about intestinal bleeding before seeking medical aid was 1.0 ± 0.70 days in the treatment group and 1.0 ± 0.35 days in the control group (p = 0.92). Group 1 included 25 patients, who were preparing for colonoscopy with sodium phosphate, Group 2 included 25 patients who were preparing for the examination with Macrogol.Results: the preparation quality was evaluated using the Boston Bowel Preparation Scale. Initially, the treatment and control groups did not have any statistically significant differences in all studied parameters. The colonoscopy identified the following nosologies. In Group 1, 9 patients had a diverticular disease of the colon; 4 – colon cancer; 12 patients continued treatment of grade 2–3 chronic internal hemorrhoids. In Group 2, the patients were distributed as follows: 10 patients were diagnosed with diverticular disease of the colon; 4 – colon cancer; 1 – an adenomatous polyp of the transverse colon and 10 patients had grade 2–3 chronic internal hemorrhoids. In addition, all patients filled out the questionnaire, which showed that the use of sodium phosphate is more convenient for the patient not only in terms of the dosage, but also due to relatively pleasant organoleptic properties. After examination of the colon, 45 patients received conservative treatment, five were operated following the colonoscopy and preoperative preparation.Conclusion: we believe that the quality of preparation of patients with intestinal bleeding with sodium sulphate and Macrogol does not differ, however, sodium sulfate is preferable because of its more pleasant organoleptic properties and the smaller volume of solution used.
Effect of vitamin D on women’s somatic and reproductive health
Authors: Zhoukovskaya I. G. , Yakupova I. R. 
Published: January 2020

The article presents the results of a study of the effect of vitamin D deficiency on women’s health.The study aimed to determine the prevalence of vitamin D deficiency and its relationship with the somatic and reproductive health of women.Methods: observation group I included 31 women with a reduced serum vitamin D levels (20.4 ± 1.0 ng/ml), comparison group II included 31 patients with normal vitamin D levels (39.0 ± 1.4 ng/ml). Results: the negative effect of vitamin D deficiency on women’s health is also practically assured, i.e. the incidence of somatic pathology is significantly higher in group I compared with group II: obesity (62.5 ± 12.1% and 18.8 ± 9.8%; p <0.5), insulin resistance (55.0 ± 9.0% and 1.0 ± 6.0%; p <0.001); arterial hypertension (42.0 ± 8.8% and 13.0 ± 6.0%; p <0.01); hypertrophic myocardiopathy (25.8 ± 7.8% and 6.4 ± 4.4%; p <0.05); chronic colitis (29.0 ± 8.1% and 6.4 ± 4.4%; p <0.05), gastric ulcer (22.5 ± 7.5% and 3.2 ± 3.2%; p <0.05), chronic pancreatitis (22.5 ± 7.5% and 3.2 ± 3.2%; p <0.05), chronic gastritis (25.8 ± 7.8% and 9.7 ± 5.3%; p <0.1). The interaction between reduced vitamin D levels and reproductive system diseases is confirmed by significant increase in the prevalence of secondary amenorrhea (80.0 ± 9.0% and 16.0 ± 7.3%; p <0.001), secondary oligomenorrhea (75.0 ± 9.7% and 20.0 ± 8.0%; p <0.001), hyperplastic processes – uterine fibroids (48.4 ± 9.0% and 13.3 ± 6.1%; p <0.001) and adenomyosis (26.6 ± 7.9% and 6.7 ± 4.5%; p <0.05), polycystic ovary syndrome (29.0 ± 8.2% and 6.7 ± 4.5%; p <0.05), vaginal microbiocenosis disorders (aerobic vaginitis – 42.0 ± 8.9% and 16.1 ± 6.6%; p <0.05; bacterial vaginosis – 29.0 ± 8.2% and 9.7 ± 5.3%; p <0.05).Conclusion: management of vitamin D level is one of the priorities in the formation of therapeutic and preventive measures to improve the women’s health.
Fetal death in the women with cholestasis pregnancy
Authors: Kachkovskiy M. A. , Kosheleva O. V. 
Published: January 2020

Background. The development of fetal death among pregnant women with cholestasis pregnancy (CP) is possible.Aim. The purposeи is to determine the interconnection between clinico-anamnestic and laboratory indicators of pregnant women with CP and fetal death.Patients and methods. 211 pregnant women were examined. The main group – 144 (68%) women with CP, controlgroup – 67 (32%) patients without symptoms of this disease. There are 2 subgroups depending on the presence or absence of fetal death among pregnant women with CP. A complex of standard clinical and diagnostic studies was performed, including obstetric ultrasound and cardiotocography. Results. In the group of patients with CP, postpartum hemorrhages (p<0.05), intrauterine fetal hypoxia (p<0.001) were significantly more frequent, fetal death was noted only in the main group (2.1%). In both subgroups miscarriages were more common in the history (p = 0.019). Most women with CHP had diseases of the hepatobiliary system, gestational hypertension and kidney disease (p<0.05). In the subgroup with fetal death arterial hypertension existed significantly more frequent before pregnancy (p<0.05). The itchy skin was extremely permanent among patients with CP and fetal death. The subgroup with fetal death significantly differed from the control group for hyperfermentemia both during pregnancy (alanine transaminase (ALT) – p<0.001, aspartate transaminase (AST) – p = 0.001, alkaline phosphatase (APH) – p = 0.001), and after delivery (ALT –p = 0.002, AST – p = 0.033, APH – p = 0.006).Conclusions. Women with CP, with a miscarriage in anamnesis or hypertension are in a risk group of fetal death. A more frequent study of the fetal condition is needed among patients with persistent itching at CP.
Safety of dabigatran in patients with atrial fibrillation and chronic kidney disease: pharmacokinetic and pharmacogenetic aspects
Authors: Skripka A. I. , Bochkov P. O. , Akmalova K. A. , Shevchenko R. V. , Krupenin P. M. , Kogay V. V. , Listratov A. I. , Krainyaya A. S. , Napalkov D. A. , Gurinovich O. S. , Sokolova A. A. , Fomin V. V. , Sychev D. A. 
Published: January 2020

Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD). This study was aimed to evaluate relationships between CES1 and ABCB1 polymorphism, dabigatran trough plasma concentration (DTPC) and bleeding events in patients with AF and CKD.Methods: patients with atrial fibrillation (AF) and stage 3 CKD treated with dabigatran 110mg or 150 mg have been included in the study. Real-time PCR was used to evaluate single nucleotide polymorphisms (SNPs) of the ABCB1 gene (rs1045642, rs4148738) and CES1 gene (rs2244613). A plasma trough concentration/dose (C/D) ratio was used as a pharmacokinetic index.Results: a total of 60 patients, aged 51–89 years (median age 76 years) were evaluated. Compared with patients given 150 mg twice a day, those given 110 mg twice a day were older (79 vs 67.5, p < 0.0001) and had lower creatinine clearance (CrCl) (50.5 vs 60.5 mL/min/1.73 m2, p = 0.015). We found C/D values to have high interindividual variability (mean 365.9 ± 290.4 μg/ml: mg/day, range 23.64-1452.73). Individuals with CKD 3B had higher concentration of dabigatran compared with those with 3A stage (488.7 ± 232.3 vs 332 ± 297.8 μg/ml : mg/day, p = 0.02). Consequently, there also was negative correlation of C/D with CrCl (r = -0.4, p = 0.0015). Evaluated SNPs (rs1045642, rs4148738, and rs2244613) did not affect C/D values (H test p > 0.05).Conclusions: C/D values were significantly higher in patients with CKD 3B stage and those treated with dabigatran 110 mg. There was no influence of aforementioned SNPs on dabigatran trough concentrations and clinical outcomes.
Frequency analysis of precipitation extremes under a changing climate: a case study in Heihe River basin, China
Authors: Tian Qingyun , Li Zhanling , Sun Xueli 
Published: January 2020

Abstract
The stationary assumption for the traditional frequency analysis of precipitation extremes has been challenged due to natural climate variability or human intervention. To overcome this challenge, this paper, taking Heihe River basin as the case study, performed the frequency analysis by developing a nonstationary GEV model for those seasonal maximum daily precipitation (SMP) time series with nonstationary characteristics by employing the GEV conditional density estimation network. In addition, the confidence intervals (CIs) of estimated return levels were also investigated by using the residual bootstrap technique. Results showed that, 7 of 12 SMP series were nonstationary. The parameters in the nonstationary model were specified as functions of time varying or correlated climate indices varying covariates. The frequency analysis showed that the return levels varied linearly or nonlinearly with covariates. Precipitation extremes with the same magnitude in the study area were found to be occurring more frequently in the future. The CIs of such return levels increased with time passing, especially those from the more complex GEV11 model, embedding a nonlinear increasing trend in model scale parameters. It implied that the increase of model complexity is likely to result in the increase of uncertainty in estimates.