bluuebunny/crossref_metadata_2025_split huggingface dataset:
Services for people with young onset dementia: The ‘Angela’ project national UK survey of service use and satisfaction
Authors: Stamou Vasileios , La Fontaine Jenny , Gage Heather , Jones Bridget , Williams Peter , O'Malley Mary , Parkes Jacqueline , Carter Janet , Oyebode Jan 
Published: September 2020

AbstractObjectivesYoung onset dementia is associated with distinctive support needs but existing research on service provision has been largely small scale and qualitative. Our objective was to explore service use, cost and satisfaction across the UK.MethodsInformation about socio‐demographic characteristics, service use and satisfaction were gathered from people with young onset dementia (YOD) and/or a family member/supporter via a national survey.ResultsTwo hundred and thirty‐three responses were analysed. Diagnosis was most commonly received through a Memory Clinic or Neurology. The type of service delivering diagnosis impacted on post‐diagnostic care. Those diagnosed in specialist YOD services were more likely to receive support within the first 6 weeks and receive ongoing care in the service where they were diagnosed. Ongoing care management arrangements varied but generally care was lacking. Around 42% reported no follow‐up during 6‐weeks after diagnosis; over a third reported seeing no health professional within the previous 3 months; just over a third had a key worker and just under a third had a care plan. Satisfaction and quality of care were highest in specialist services. Almost 60% of family members spent over 5 h per day caring; median costs of health and social care, 3 months, 2018, were £394 (interquartile range £389 to 640).ConclusionsVariation across diagnostic and post‐diagnostic care pathways for YOD leads to disparate experiences, with specialist young onset services being associated with better continuity, quality and satisfaction. More specialist services are needed so all with YOD can access age‐appropriate care.
Cytogenetic study in primary myelofibrosis at diagnosis: Clinical and histological association and impact on survival according to WHO 2017 classification in an Italian multicenter series
Authors: Iurlo Alessandra , Palandri Francesca , Maria Elli Elena , Cattaneo Daniele , Bucelli Cristina , Sciumè Mariarita , Vincelli Donatella , Brioschi Filippo , Auteri Giuseppe , Croci Giorgio Alberto , Guerneri Silvana , Isimbaldi Giuseppe , Sabattini Elena , Cortinovis Ivan , Bossi Anna , Rosti Vittorio , Martino Bruno , Baldini Luca , Gianelli Umberto 
Published: September 2020

AbstractWe analyzed cytogenetic data at diagnosis in 395 primary myelofibrosis (PMF) patients to evaluate any possible association between karyotype and WHO 2017 classification and its impact on prognosis. All the cases were diagnosed and followed at five Italian Hematological Centers between November 1983 and December 2016. An abnormal karyotype (AK) was found in 69 patients and clustered differently according to bone marrow fibrosis grade as it was found in 31 (27.0%) cases with overt fibrotic and 38 (13.6%) with pre‐fibrotic PMF (p = 0.001). Sex, anemia, thrombocytopenia, circulating blasts ≥1%, higher lactate dehydrogenase, and International Prognostic Scoring System risk classes were all significantly associated with karyotype. At a median follow‐up of >6 years, 101 deaths were recorded. Survival was different between AK and normal karyotype (NK) patients with an estimated median overall survival (OS) of 11.6 and 25.7 years, respectively (p = 0.0148). In conclusion, in our cohort around 20% of patients had an AK, more frequently in subjects with an advanced bone marrow fibrosis grade and clinical‐laboratory features indicative of a more aggressive disease. This study shows that an AK confers a more severe clinical phenotype and impacts adversely on OS, thus representing an additional parameter to be considered in the evaluation of PMF prognosis.
Ibrutinib in relapsed hairy cell leukemia variant: A case report and review of the literature
Authors: Visentin Andrea , Imbergamo Silvia , Trimarco Valentina , Pravato Stefano , Romano Gargarella Leila , Frezzato Federica , Scapinello Greta , Bertorelle Roberta , Piva Elisa , Facco Monica , Semenzato Gianpietro , Piazza Francesco , Trentin Livio 
Published: September 2020

AbstractHairy cell leukemia variant (HCLv) is a provisional disease in the 2016 WHO classification of lymphomas, characterized by unfavorable prognosis and early relapse following conventional purine analog‐based regimens. In this study, we report 2 patients with relapsed HCLv treated with ibrutinib. The first patient achieved a partial response following ibrutinib treatment and received the drug for 16 months, without severe adverse events. However, at disease progression venetoclax was not clinically active. The second patient discontinued the drug early due to intolerance. Ibrutinib was active in our patients with HCLv and deserve further investigations.
Outcomes of second hematopoietic stem cell transplantation using reduced‐intensity conditioning in an outpatient setting
Authors: Jaime‐Pérez José Carlos , Picón‐Galindo Ernesto , Herrera‐Garza José Luis , Gómez‐Almaguer David 
Published: September 2020

AbstractRelapse and graft failure after autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT) are serious and frequently fatal events. A second HSCT can be a life‐saving alternative, however, information on the results of such intervention in an outpatient setting is limited. Outpatient second hematoprogenitors transplant after reduced‐intensity conditioning (RIC) at a single academic center was analyzed. Twenty‐seven consecutive adults who received an allo‐HSCT after an initial auto‐ or allo‐HSCT from 2006 to 2019 were included. Data were compared using the χ2‐test. Survival analysis using Kaplan–Meier and Cox proportional hazard models was performed; cumulative incidence estimation of transplant‐related mortality (TRM) was assessed. Hodgkin lymphoma was the most frequent diagnosis for the group with a first auto‐HSCT with 5/12 (41.7%) cases, and acute myeloid leukemia for those with a first allo‐HSCT with 6/15 (40%). One‐year overall survival and disease‐free survival (DFS) was 66.7% (95% CI 27.2–88.2) and 59% (95% CI 16–86) for 12 patients with a first auto‐HSCT; and for 15 patients with a first allo‐HSCT, it was 43.3% (95% CI 17.9–66.5) and 36% (95% CI 13.2–59.9), respectively. Eight (29.6%) patients died of TRM and the cumulative incidence of TRM at 1 year was 22% (95% CI 8.6–39.27). Chronic graft‐versus‐host disease and late (>10 months) second transplantation were protective factors for longer survival. Neutropenic fever was more common in the group with a first allo‐HSCT (p = 0.01). In conclusion, outpatient second allo‐HSCT using RIC after auto‐ or allografting failure or relapse is feasible and offers a reasonable alternative for patients with severe life‐threatening hematological diseases.
Prophylactic corticosteroid use prevents engraftment syndrome in patients after autologous stem cell transplantation
Authors: Betticher Christophe , Bacher Ulrike , Legros Myriam , Zimmerli Stefan , Banz Yara , Mansouri Taleghani Behrouz , Pabst Thomas 
Published: September 2020

AbstractEngraftment syndrome (ES) following autologous stem cell transplantation (ASCT) at the time of neutrophil recovery may comprise fever, rash, pulmonary edema, or diarrhea. Usually, ES is easily manageable using corticosteroids but may prolong hospitalization. In two consecutive cohorts of subsequent patients with myeloma, lymphomas, and testicular/germ cell cancer, we assessed the benefit of corticosteroid use to prevent incidence and severity of ES following ASCT. Whereas Cohort A (82 patients) received no prophylactic corticosteroids, corticosteroids (4 mg dexamethasone oral daily) were started in Cohort B (60 patients) at day +9 until day +13 following ASCT. Steroid prophylaxis significantly reduced the incidence of ES (6/60; 10% vs. 33/82; 40%; p < 0.001). Hospitalization duration was longer in patients with ES than in patients without ES within both cohorts (in Cohort A: p = 0.007; and B: p = 0.011), but did not differ significantly between cohorts A and B. Finally, in Cohort A, there was a trend to an inferior 2‐year overall survival rate in patients without ES compared to patients with ES (p = 0.067), but definite conclusions are not yet allowed. Our results suggest that corticosteroid prophylaxis from days +9 to +13 following ASCT significantly reduces the risk of ES and shortens hospitalization duration.
How investment in public health has impacted the prevalence of tuberculosis in China: A study of provincial variations between 2005 and 2015
Authors: Liu Jie , Han Ziqiang , Veuthey Justin , Ma Ben 
Published: September 2020

AbstractHow do public investments in public health actually impact health outcomes? This question has not been investigated enough, especially regarding infectious diseases. This study investigates the correlations between public health expenditure and the incidence of tuberculosis in China using a provincial panel dataset. The analysis focuses on the correlations between public health expenditure and tuberculosis incidence, using the fixed effects models and Two Stage Least Squares (2SLS) method. Overall, a 10% increase of public health expenditure per capita is associated with a 0.0019% decrease of tuberculosis incidence. A series of robustness tests show that the correlation between public health expenditure and TB incidence is valid. Future research should focus more on the performance of public health, particularly infectious diseases like tuberculosis, and provide references for health policymakers.
Bioethics and healthcare policies. The benefit of using genetic tests of BRCA 1 and BRCA 2 in elderly patients
Authors: Fonseca Vasco , Caeiro Joaquim 
Published: September 2020

AbstractThis study focuses on the role of bioethics in designing public healthcare policies towards elderly patients with cancer. The general overview of public administration and healthcare approach to treatment. Interpretation of how the EU public administration faces the challenges of an ageing population and extended human longevity. The significant emotional impact a genetic cancer test holds, both in the patients and their families, is to be explained. From the bioethics' perspective, artificial intelligence and transhumanism are dangerous concerning its absence of boundaries. As a result of daily contact with cancer, we acknowledge the immediate and relevant impact science produces in a patient's life. We converge these subjects to the improvement of public policies and governmental efforts in increasing society's positive results.
Refining image‐velocimetry performances for streamflow monitoring: Seeding metrics to errors minimization
Authors: Pizarro Alonso , Dal Sasso Silvano Fortunato , Manfreda Salvatore 
Published: September 2020

AbstractRiver streamflow monitoring is currently facing a transformation due to the emerging of new innovative technologies. Fixed and mobile measuring systems are capable of quantifying surface flow velocities and discharges, relying on video acquisitions. This camera‐gauging framework is sensitive to what the camera can “observe” but also to field circumstances such as challenging weather conditions, river background transparency, transiting seeding characteristics, among others. This short communication paper introduces the novel idea of optimizing image velocimetry techniques selecting the most informative sequence of frames within the available video. The selection of the optimal frame window is based on two reasonable criteria: (a) the maximization of the number of frames, subject to (b) the minimization of the recently introduced dimensionless seeding distribution index (SDI). SDI combines seeding characteristics such as seeding density and spatial clustering of tracers, which are used as a proxy to enhance the reliability of image velocimetry techniques. Two field case studies were considered as a proof‐of‐concept of the proposed framework, on which seeding metrics were estimated and averaged in time to select the proper application window. The selected frames were analysed using LSPIV to estimate the surface flow velocities and river discharge. Results highlighted that the proposed framework might lead to a significant error reduction. In particular, the computed discharge errors, at the optimal portion of the footage, were about 0.40% and 0.12% for each case study, respectively. These values were lower than those obtained, considering all frames available.
Glyphosate Toxicity to Native Nontarget Macrophytes Following Three Different Routes of Incidental Exposure
Authors: Sesin Verena , Davy Christina M , Stevens Kevin J , Hamp Rebekah , Freeland Joanna R 
Published: September 2020

Abstract
A major goal of invasive plant management is the restoration of native biodiversity, but effective methods for invasive plant control can be harmful to native plants. Informed application of control methods is required to reach restoration goals. The herbicide glyphosate, commonly applied in invasive plant management, can be toxic to native macrophytes. Our study assessed the response of 2 macrophytes that are endangered in our study area (Ammannia robusta and Sida hermaphrodita) to glyphosate concentrations that mimic incidental exposure from nearby invasive plant control: spray drift of 4 × 10−7% to 5% glyphosate; pulse and continuous immersion in water containing 2 to 41 µg/L glyphosate; and rhizosphere contact with 5%-glyphosate-wicked invasive plants. We assessed macrophyte sensitivity at 14-d postexposure, and quantified abundance of arbuscular mycorrhizal fungi. Glyphosate spray concentrations as low as 0.1% reduced macrophyte growth. Ammannia was more sensitive overall to glyphosate spray than Sida, although sensitivity varied among measured endpoints. Conversely, macrophytes were not affected by immersion in low concentrations of glyphosate or rhizosphere contact with a glyphosate-wicked plant. Likewise, arbuscular mycorrhizal fungi abundance in roots was similar among glyphosate-sprayed and control plants. Based on our results, we recommend that invasive plant managers reduce risks to native nontarget plants through implementing measures that limit off-target spray drift, and consider the feasibility of more targeted applications, such as with wick equipment. Integr Environ Assess Manag 2021;17:597–613. © 2020 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC)
KEY POINTS
We assessed the response of nontarget, endangered macrophytes and associated mycorrhizal fungi to glyphosate exposures that mimicked realistic scenarios encountered during invasive plant control. Glyphosate toxicity to macrophytes varied with the exposure pathway, where spray at low concentrations reduced native macrophyte growth, but no effects were detected from low-level surface water residues or adjacent wick-application. Mycorrhizal fungi in macrophyte roots were not affected by glyphosate spray. We recommend that glyphosate-based invasive plant management implements measures to limit off-target spray drift, and that risk assessment procedures for nontarget macrophytes consider adding spray exposure tests with emergent species to their repertoire.
Physical activity before and during pregnancy: A cohort study
Authors: Román‐Gálvez María Rosario , Amezcua‐Prieto Carmen , Salcedo‐Bellido Inmaculada , Olmedo‐Requena Rocío , Martínez‐Galiano Juan Miguel , Khan Khalid S. , Bueno‐Cavanillas Aurora 
Published: September 2020

AbstractObjectiveTo estimate physical activity (PA) in healthy women before and during pregnancy and to evaluate the features associated with moderate PA (MPA).MethodsA prospective cohort study was conducted on women selected 14 weeks of pregnancy during 2013–2015 in primary public health service centers in southern Spain. Type, duration, and frequency of PA (IPAQ questionnaire in first, second, and third trimesters [T1, T2, T3]) were measured. Variables associated with MPA were evaluated using multiple logistic regressions controlling for age, pre‐pregnancy obesity, level of education, number of living children, pre‐pregnancy PA, and adherence to Mediterranean diet (AMD).ResultsOut of 463 women, MPA was estimated in 64% pre‐pregnancy, and 54%, 61%, and 59% in T1, T2, and T3, respectively. MPA was associated with greater AMD in T2 (adjusted odds ratio [aOR] 1.17, 95% confidence interval [CI] 1.04–1.33) and T3 (aOR 1.16, 95% CI 1.02–1.31), previous PA (aOR 13.5, 95% CI 8.12–22.5 in T1; aOR 2.61, 95% CI 1.72–3.96 in T2; aOR 2.59, 95% CI 1.65–4.05 in T3), and pre‐pregnancy obesity (aOR 2.97, 95% CI 1.28–6.89 in T1; aOR 2.69, 95% CI 1.23–3.60 in T3).ConclusionPA decreased at the beginning of pregnancy, but compliance remained over 50%. MPA was associated with diet, pre‐pregnancy PA, and obesity.
Maternal mental health and coping during the COVID‐19 lockdown in the UK: Data from the COVID‐19 New Mum Study
Authors: Dib Sarah , Rougeaux Emeline , Vázquez‐Vázquez Adriana , Wells Jonathan C. K. , Fewtrell Mary 
Published: September 2020

AbstractObjectiveTo assess how mothers are feeling and coping during lockdown, and to identify the potential pathways that can assist them.MethodsA descriptive analysis of maternal mental health, coping, support, activities, lockdown consequences was conducted. Women living in the UK with an infant aged ≤12 months completed an online survey. Linear regression was used to identify predictors of maternal mental health and coping.ResultsA majority of the 1329 participants reported feeling down (56%), lonely (59%), irritable (62%), and worried (71%) to some extent since lockdown began, but 70% felt able to cope. Support with her own health (95% confidence interval [CI] 0.004–0.235), contacting infant support groups (95% CI −0.003 to 0.252), and higher gestational age of the infant (95% CI 0.000–0.063) predicted better mental health. Travelling for work (95% CI −0.680 to −0.121), the impact of lockdown on the ability to afford food (95% CI −1.202 to −0.177), and having an income <£30 000 (95% CI −0.475 to −0.042) predicted poorer mental health. Support with her own health and more equal division of household chores were associated with better coping.ConclusionThere is a need to assess maternal mental health and identify prevention strategies for mothers during lockdown.
Preoperative monocyte‐to‐HDL‐cholesterol ratio predicts early recurrence after radiofrequency maze procedure of valvular atrial fibrillation
Authors: Adili Ailiya , Wang Yali , Zhu Xiyu , Cao Hailong , Fan Fudong , Tang Xinlong , Zhou Qing , Wang Dongjin 
Published: September 2020

AbstractBackgroundMonocyte‐to‐high‐density lipoprotein (M/H) ratio has emerged as a novel cardiovascular prognostic biomarker. We aimed to evaluate the prognostic values of M/H with early recurrence in persistent valvular atrial fibrillation (AF) patients after radiofrequency (RF) maze procedure.MethodsWe retrospectively analyzed 131 consecutive persistent AF patients with valvular heart diseases who were followed up 3 months after RF maze procedure. Their clinical data were recorded. Logistic regression analyses were performed for significant predictors. Receiver operating characteristic analysis was used for validation with corresponding area under the curve.Results70 (53.4%) patients experienced early recurrence after procedure. Patients with early recurrence were older, have longer AF duration history, larger left atria diameter (LAD), higher plasma C‐reactive protein (CRP), lower triglycerides (TG), lower cholesterol (TC), increased monocyte counts, lower HDL cholesterol, and increased M/H ratio. In multivariate analysis, age (OR 1.1 95% CI 1.0‐1.1 P = .003), LAD (OR 2.1, 95%CI 1.2‐3.5, P = .006), TG (OR 0.35, 95% CI 0.15‐0.84, P = .019), M/H (OR 6.1, 95% CI 2.9‐13.0, P < .001) were significantly independent predictors of AF early recurrence. M/H ratio demonstrated a significant predictive value (AUC = 0.77, sensitivity 89.0%, specificity 54%). Further, there was a positive correlation of M/H ratio with CRP and white blood cell.ConclusionPreoperative M/H ratio was an independent risk factor of AF early recurrence following RF maze operation. M/H ratio should be considered in prediction of early recurrence for valvular AF patients.
Populus ciliata mediated synthesis of silver nanoparticles and their antibacterial activity
Authors: Hafeez Muhammad , Zeb Maryum , Khan Abdullah , Akram Bilal , Abdin Zain‐ul , Haq Sirajul , Zaheer Muhammad , Ali Shaukat 
Published: September 2020

AbstractDesign and synthesis of bactericidal and fungicidal agents is very important to protect human beings from different diseases. Silver nanoparticles (AgNPs) possess good bactericidal properties. Synthesis of these nanoparticles (NPs) via green route is cost‐effective and environmentally harmonious as compared to the chemical and physical approaches. In this work, AgNPs were synthesized through green synthesis method using Populus ciliata leaf extract. The synthesized AgNPs were characterized by x‐ray diffraction (XRD), ultraviolet‐visible (UV‐Vis) spectroscopy, Fourier‐transform infrared (FT‐IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive x‐ray (EDX) techniques. The XRD pattern depicted the characteristic Bragg's peaks of (111), (200), (220), and (311) planes which are the features of face centered cubic (FCC) geometry of the synthesized AgNPs. TEM micrographs revealed the spherical shaped particles having average size of 4 nm. The AgNPs showed inhibitory effects against selected gram positive (Staphylococcus epidermidis and Streptococcus pyogenes) and gram negative bacteria (Klebsiella pneumoniae, Serratia marcescens, and Pseudomonas pseudoalcaligenes). The maximum zone of inhibition (26 mm) was observed for gram negative bacterium (Serratia marcescens) when 25 mg/ml solution of AgNPs was used and for similar concentration of these NPs, the maximum zone of inhibition (25 mm) was observed against gram positive bacteria (S. pyogenes). The results indicated good bactericidal potential of the synthesized AgNPs.Research Highlights
Populus ciliata leaf extract mediated synthesis of AgNPs.
Transmission electron microscopy analysis revealed very small size of the synthesized AgNPs (4 nm).
The synthesized AgNPs were found very effective against various bacterial pathogens.