bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relative success of frost-resistant variants of Avena fatua: a field experiment
Authors: Darmency H. , Fleury A. 
Published: December 2020

AbstractWhile climate change mainly applies to global warming and subsequent drought periods, freezing periods also are changing and may trigger genetic adaptation. However, there are few prospective, experimental demonstrations. This paper investigates how effectively genetic frost-resistant variants can respond differently to frost periods, especially in farmers’ fields where various other selection pressures occur. An experiment using Avena fatua variants was set up in the field over 8 years of winter crop rotation. The frequency of each variant identified by their leaf isozymes was estimated every year. Six years were necessary to observe a weak trend towards an increased frequency of the frost-resistant phenotype, while the other variants had apparent erratic behaviour. Selection of the frost-resistant variant was challenged by irregular low temperature selection pressure, differential dormancy, germination and seed production, and possibly herbicide sensitivity that mitigated the expression of the selection response. This experiment shows how plant polymorphism and farmers’ practices that superimpose habitat unpredictability diversify possible responses to selection pressures and delay adaptation. However, if climate change brings both higher mean temperatures and extreme values, changes of apparent plant phenology could happen for weeds species displaying the appropriate genetic variability within the time-frame of farmers’ career, thus necessitating correlative adaptation of farming practices.
Denaturation of selected bioactive whey proteins during pasteurization and their ability to modulate milk immunogenicity
Authors: Bogahawaththa Dimuthu , Vasiljevic Todor 
Published: December 2020

AbstractThis research communication relates to the hypothesis that the consumption of raw or unprocessed cow's milk contributes to lowered prevalence of allergies. Thermal pasteurization of bovine milk can result in denaturation of minor whey proteins and loss of their bioactivity. Denaturation of bovine serum albumin (BSA), immunoglobulin G (IgG) and lactoferrin (LF) in skim milk was studied under different temperature (72, 75 or 78°C) and time (0–300 s) combinations. Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) results revealed that denaturation of all 3 proteins occurred at 72°C and progressed with increase in temperature and holding time. About 59% of LF and 12% of IgG denatured under high-temperature short-time (72°C/ 15 s) pasteurization, while BSA was least impacted. To assess modulation of milk immunogenicity, secretion of selected T helper (Th)-type cytokines by human peripheral blood mononuclear cells (PBMCs) was studied in vitro in response to different concentrations of BSA (0.4–1.0 mg/ml) and IgG (0.8–1.6 mg/ml) in unheated skim milk. Addition of IgG at 1.6 mg/ml induced a prominent Th1-skewed cytokine profile that may not trigger a Th2-skewed allergic reaction. BSA did not appear to modulate milk immunogenicity to any significant extent.
Prospective enzymes for omega-3 PUFA biosynthesis found in endoparasitic classes within the phylum Platyhelminthes
Authors: Babaran D. , Arts M.T. , Botelho R.J. , Locke S.A. , Koprivnikar J. 
Published: December 2020

Abstract
The free-living infectious stages of macroparasites, specifically, the cercariae of trematodes (flatworms), are likely to be significant (albeit underappreciated) vectors of nutritionally important polyunsaturated fatty acids (PUFA) to consumers within aquatic food webs, and other macroparasites could serve similar roles. In the context of de novo omega-3 (n-3) PUFA biosynthesis, it was thought that most animals lack the fatty acid (FA) desaturase enzymes that convert stearic acid (18:0) into ɑ-linolenic acid (ALA; 18:3n-3), the main FA precursor for n-3 long-chain PUFA. Recently, novel sequences of these enzymes were recovered from 80 species from six invertebrate phyla, with experimental confirmation of gene function in five phyla. Given this wide distribution, and the unusual attributes of flatworm genomes, we conducted an additional search for genes for de novo n-3 PUFA in the phylum Platyhelminthes. Searches with experimentally confirmed sequences from Rotifera recovered nine relevant FA desaturase sequences from eight species in four genera in the two exclusively endoparasite classes (Trematoda and Cestoda). These results could indicate adaptations of these particular parasite species, or may reflect the uneven taxonomic coverage of sequence databases. Although additional genomic data and, particularly, experimental study of gene functionality are important future validation steps, our results indicate endoparasitic platyhelminths may have enzymes for de novo n-3 PUFA biosynthesis, thereby contributing to global PUFA production, but also representing a potential target for clinical antihelmintic applications.
The Structure of Religion, Ethnicity, and Insurgent Mobilization
Authors: Sarbahi Anoop 
Published: December 2020

ABSTRACTThis article problematizes the social structure of ethnic groups to account for variation in insurgent mobilization within and across ethnic groups. Relying on network-based approaches to social structure, it argues that insurgent mobilization is constrained by the structural connectivity of the ethnic group, a measure of the extent to which subethnic communities—neighborhoods, villages, clans, and tribes—are socially connected internally and with each other. In agrarian societies, structural connectivity is traced to religion. On the basis of unique data on rebel recruitment from the Mizo insurgency in India and microlevel variations in changes associated with the spread of Christianity among Mizos, the author demonstrates that enhanced structural connectivity resulting from a network of highly centralized churches and institutions under the Welsh Presbyterian Mission significantly bolstered insurgent recruitment. Semistructured interviews of Mizo insurgents and ethnographic evidence from the neighboring Meitei and Naga ethnic insurgencies further support the argument and the casual mechanism.
Characterization of a hospital-based gastroenteritis outbreak caused by GII.6 norovirus in Jinshan, China
Authors: Zhang X. F. , Chen J. R. , Song C. L. , Xie D. J. , Tan M. , Wang L. , Koroma M. M. , Hou Y. Z. , Dong Z. P. , Yu J. R. , Duan W. T. , Zhao D. D. , Du J. R. , Zhu L. , Dai Y. C. 
Published: December 2020

Abstract
An acute gastroenteritis (AGE) outbreak caused by a norovirus occurred at a hospital in Shanghai, China, was studied for molecular epidemiology, host susceptibility and serological roles. Rectal and environmental swabs, paired serum samples and saliva specimens were collected. Pathogens were detected by real-time polymerase chain reaction and DNA sequencing. Histo-blood group antigens (HBGA) phenotypes of saliva samples and their binding to norovirus protruding proteins were determined by enzyme-linked immunosorbent assay. The HBGA-binding interfaces and the surrounding region were analysed by the MegAlign program of DNAstar 7.1. Twenty-seven individuals in two care units were attacked with AGE at attack rates of 9.02 and 11.68%. Eighteen (78.2%) symptomatic and five (38.4%) asymptomatic individuals were GII.6/b norovirus positive. Saliva-based HBGA phenotyping showed that all symptomatic and asymptomatic cases belonged to A, B, AB or O secretors. Only four (16.7%) out of the 24 tested serum samples showed low blockade activity against HBGA-norovirus binding at the acute phase, whereas 11 (45.8%) samples at the convalescence stage showed seroconversion of such blockade. Specific blockade antibody in the population played an essential role in this norovirus epidemic. A wide HBGA-binding spectrum of GII.6 supports a need for continuous health attention and surveillance in different settings.
Recommendations from the Association for European Paediatric and Congenital Cardiology for training in diagnostic and interventional electrophysiology
Authors: Kriebel Thomas , Rosenthal Eric , Gebauer Roman , Happonen Juha-Matti , Drago Fabrizio , Krause Ulrich , Blom Nico A. , Książczyk Tomasz , Kornyei Laszlo 
Published: December 2020

AbstractThe field of electrophysiology (EP) in paediatric cardiology patients and adults with congenital heart disease is complex and rapidly growing. The current recommendations for diagnostic and invasive electrophysiology of the working group for Cardiac Dysrhythmias and Electrophysiology of the Association for European Paediatric and Congenital Cardiology acknowledges the diveristy of European countries and centers. These training recommendations can be fulfilled in a manageable period of time, without compromising the quality of training required to become an expert in the field of paediatric and congenital EP and are for trainees undergoing or having completed accredited paediatric cardiologist fellowship. Three levels of expertise, the training for General paediatric cardiology EP, for non-invasive EP and invasive EP have been defined. This Association for European EP curriculum describes the theoretical and practicsal knowledge in clinical EP; catheter ablation, cardiac implantable electronic devices, inherited arrhythmias and arrhythmias in adults with congenital heart defects for the 3 levels of expertise.
Risk factors and lifelong impact of community-acquired pneumonia in congenital heart disease
Authors: Evers Patrick D. , Farkas Dóra K. , Khoury Michael , Olsen Morten , Madsen Nicolas L. 
Published: December 2020

AbstractIntroduction:The prevalence of congenital heart disease (CHD) in adults is rising necessitating a greater understanding of acquired diseases such as community-acquired pneumonia, which remains a leading cause of age-related mortality and morbidity in the general population. We hypothesise that the CHD population, given cardiopulmonary mechanics and altered immune function, bears a uniquely high risk for pneumonia-related hospitalisations and mortality.Methods:A countrywide cohort study was performed to calculate the relative risk and cumulative incidence of pneumonia hospitalisations and resultant 30-day mortality amongst the adult CHD population, matched 1:10 with non-CHD persons by gender, age, and adjusted for comorbidities. Cox proportional hazard regression quantified the impact of CHD severity and extracardiac defects.Results:The CHD cohort includes 17,162 adults. The majority demonstrate mild/moderate CHD complexity. The cumulative incidence of pneumonia hospitalisation was higher for adults with CHD (hazard ratio 1.90; 95% confidence interval: 1.74–2.06) than the comparison cohort. This risk was increased for those with extracardiac defects or a syndrome (hazard ratio: 4.34; 95% confidence interval: 3.39–5.54). Additionally, CHD individuals with severe/univentricular subtypes demonstrate a heightened risk compared to the non-CHD cohort (hazard ratio: 2.35; 95% confidence interval: 1.94–2.84), as well as compared to those with mild/moderate CHD (hazard ratio: 1.28; 95% confidence interval: 1.07–1.53). In addition, pneumonia hospitalisation mortality was elevated above the comparison population with a 30-day mortality rate ratio of 1.31 (95% confidence interval: 1.00–1.73).Conclusion:Adults with CHD are at elevated risk of pneumonia hospitalisations and pneumonia-associated mortality. This risk is further elevated in those with severe CHD and extracardiac defects.
Veno-arterial CO2 difference and cardiac index in children after cardiac surgery
Authors: Insom Giulia , Marinari Eleonora , Scolari Anna Francesca , Garisto Cristiana , Vitale Vincenzo , Di Chiara Luca , Ricci Zaccaria 
Published: December 2020

AbstractVeno-arterial CO2 difference has been considered as a marker of low cardiac output. This study aimed to evaluate the correlation between veno-arterial CO2 difference and cardiac index estimated by MostCareTM in children after cardiac surgery and its association with other indirect perfusion parameters and the complex clinical course (vasoactive inotropic score above 15 or length of stay above 5 days).Data from 40 patients and 127 arterial and venous CO2 measurements for gap calculation taken 0–5 days postoperatively were available. The median (range) veno-arterial CO2 difference value was 9 (1–25 mmHg). The correlation between veno-arterial CO2 difference and cardiac index was not significant (r: −0.16, p = 0.08). However, there was a significant correlation between veno-arterial CO2 difference and vasoactive inotropic score (r: 0.21, p = 0.02), systolic arterial pressure (r: −0.43, p = 0.0001), dP/dtMAX (r: 0.26, p = 0.004), and arterio-venous O2 difference (r: 0.63, p = 0.0001). Systolic arterial pressure (OR 0.95, 95% CI 0.90–0.99), dP/dtMAX (OR 0.00, 95% CI 0.00–0.06), lactates (OR 1.87, 95% CI 1.21–3.31), and veno-arterial CO2 difference (OR 1.13, 95% CI 1.01–1.35) showed a significant univariate association with the complex clinical course. In conclusion, veno-arterial CO2 difference did not correlate with cardiac index estimated by MostCareTM in our cohort of post-cardiosurgical children, but it identified patients with the complex clinical course, especially when combined with other direct and indirect variables of perfusion.
Straddling between Different Worlds: Navigating Diverse Fieldwork Modes
Authors: Anugrah Iqra 
Published: December 2020

ABSTRACTFieldwork often is seen as a challenging and misunderstood intellectual enterprise. Long perceived as the domain of the few, fieldwork and immersion continue to be the chosen methodological techniques for many political scientists. Focusing on my own fieldwork experience in Indonesia since 2015 as an early-career researcher, I discuss and reflect on three types of activities: (1) policy research, (2) dissertation research, and (3) activist work. In particular, I highlight fieldwork serendipities, fieldwork logistics, and my experience in gathering data and interacting with various interlocutors. It is hoped that this self-reflection will help readers to better understand the relationship between researchers and their interlocutors and collaborators, demystify the fieldwork process, and better prepare political scientists who use fieldwork in their research.
Classifying and Defining Deities in the Late Vedic Age: A Study and an Annotated Translation of Yāska's Nirukta Chapter 7
Authors: VISIGALLI PAOLO , KAWAMURA YŪTO 
Published: December 2020

AbstractYāska's Nirukta (ca. fifth-third century bce), the seminal text of the Sanskritic discipline of nirvacana or ‘etymology’, is one of the most important yet least studied late Vedic texts. Particularly little attention has been paid to Nirukta Chapter 7. This chapter outlines Yāska's views on Vedic deities and articulates the hermeneutic principles whereby they are classified and defined. It plays a crucial, yet underappreciated, role in the history of ancient India's theological and hermeneutical speculations. The absence of an accessible English translation, which tackles the text's many conceptual and linguistic complexities, is the main reason why Nirukta Chapter 7 has not received the attention it deserves. We offer the first complete annotated English translation in a century. A comprehensive introduction clarifies the structure and rationale of Chapter 7 and elucidates the salient features of Yāska's theology.
Prevalence of common mental disorders among Syrian refugee children and adolescents in Sultanbeyli district, Istanbul: results of a population-based survey
Authors: Scherer N. , Hameed S. , Acarturk C. , Deniz G. , Sheikhani A. , Volkan S. , Örücü A. , Pivato I. , Akıncı İ. , Patterson A. , Polack S. 
Published: December 2020

AbstractAimsResearch demonstrates elevated levels of common mental disorders among Syrian refugees, but the majority of studies have, to date, focused on adult populations. This study aims to estimate the prevalence of depression, anxiety and post-traumatic stress disorder (PTSD) among Syrian children and adolescents living in Sultanbeyli district of Istanbul, Turkey.MethodsA population-based survey among Syrian children and adolescents aged 8–17 years living in Sultanbeyli district was conducted in 2019, as part of an all-age survey of disability. 80 clusters of 50 participants (all-ages) were selected from the local municipality's refugee registration database using probability proportionate to size sampling. Children aged 8–17 years were assessed for symptoms of common mental disorders using the Child Revised Impact of Event Scale (CRIES-8) and abbreviated versions of the Center for Epidemiologic Studies Depression Scale for Children (CES-DC) and the Screen for Child Anxiety Related Disorders (SCARED).ResultsOf the 852 participants, 23.7% (95% CI 19.9-27.2) screened positive for symptomatic depression, PTSD and anxiety. The prevalence estimates for depression, PTSD and anxiety were 12.5% (95% CI 9.8–15.6), 11.5% (95% CI 9.1–14.4) and 9.2% (95% CI 6.8–12.1), respectively. Depression and PTSD were significantly more common in older adolescents, whilst anxiety and PTSD were significantly more common in girls. Depression was more common in children from poorer households and those who had received no education. Children coming from larger households were less likely to show symptoms of PTSD.ConclusionsSyrian refugee children and adolescents are vulnerable to common mental disorders, and culturally appropriate prevention and intervention support are needed for this population.
Host Rock Variability Powers the Diversity of Steam‐Driven Eruptions
Authors: Montanaro Cristian , Cronin Shane J. , Scheu Bettina , Kennedy Ben , Scott Bradley J. , Dingwell Donald B. 
Published: December 2020

AbstractSteam‐driven eruptions are explosive events that are fueled by pressurized water and steam trapped within rock and sediments. We show how rock properties modulate explosion size, dynamics, and hazard footprint based on examples from Lake Okaro (New Zealand). Laboratory decompression experiments demonstrate that fragmentation of strong/unaltered host rocks comes with a high energy cost (∼10%–11% of bulk explosion energy). Consequently a low energy fraction (∼7%–8%) remains for kinetic energy and thus particle ejection. In contrast, disaggregation of unconsolidated sediments requires little energy (<2%–7%), allowing higher outputs of kinetic energy (22%–25%), and more efficient debris dispersion. Experimental estimates of bulk explosive energies are consistent with both field observations and empirical models applied to Lake Okaro crater dimensions. This integration of experimental methods, field observations, and empirical modeling underscores the dominant role of alteration state and host rock lithology when estimating crater‐forming and ballistic hazards in volcanic/geothermal areas.
An Autogenic Cycle of Fluvial Transience in Dipping, Layered Rocks
Authors: Sheehan C. E. , Ward D. J. 
Published: December 2020

AbstractWe describe an autogenic process by which steady fluvial incision through dipping, layered rocks of different erodibilities cyclically generates migrating drainage divides. We develop an analytical expression for calculating the autogenic periodicity, test it by simulating the incision of idealized strike valleys with a landscape evolution model, and apply our models to estimate the autogenic periodicity within two strike valleys in central Utah. Our analysis suggests that depending on the long‐term incision rate of the San Rafael River network, the autogenic periodicity within the two valleys can overlap with the ∼100 kyr glacial‐interglacial period of climatic forcing, in which case the two different signals would be difficult to separate. Our method should apply to other regions of dipping layered rocks and can be used as a preliminary test to assess whether autogenic or exogenic forcings are more likely to have created a given set of transient features.
Geomorphic Evidence for the Presence of Ice Deposits in the Permanently Shadowed Regions of Scott‐E Crater on the Moon
Authors: Moon Seulgi , Paige David A , Siegler Matthew A , Russell Patrick S 
Published: December 2020

AbstractThe abundance and distribution of ice on the Moon are still unknown. Here, we examine the connections between geomorphic characteristics and the potential presence of lunar ice in permanently shadowed regions of the Scott‐E crater in the lunar south polar region. We first quantify surface characteristics, such as roughness, based on high‐resolution optical images and topography data and then model spatial variations of water ice stability using a high‐resolution thermal model. We find that the surface roughness in regions where thermally stable surface ice is predicted is significantly lower than in adjacent regions where subsurface ice or no ice is predicted. This correspondence may result from processes such as preferential cold‐trapping in depressions or high albedo areas, or enhanced regolith transport in the ice‐rich regolith.
Impacts of Hurricane Maria on Land and Convection Modification Over Puerto Rico
Authors: Hosannah N. , Ramamurthy P. , Marti J. , Munoz J. , González J. E. 
Published: December 2020

AbstractHurricane Maria drastically altered the landscape across the island of Puerto Rico. This article investigates modifications to surface‐atmospheric interactions due to Hurricane Maria induced land damage and the associated impacts on local convective dynamics. Herein, we employed LANDSAT‐8 image mosaics to quantify the hurricane induced land modification. Results of the analysis indicate that the island suffered significant forest damage—much of which registered as a 28.35% increase in barren land and a 10.85% increase in pasture. Smaller changes included a decrease in cultivated agricultural land cover by 0.76%, along with wetland and water increases of 0.62% and 0.25%, respectively. Pre and postMaria land classifications were then assimilated into the Regional Atmospheric Modeling System cloud resolving model for the simulation of the June 23 to July 2, 2018 period under two land conditions. Results of the numerical experiments indicate that surface to atmosphere interactions were significantly modified when the land cover was altered, and that the highest deviations between pre and postMaria convection occurred over elevated areas with extreme hurricane induced land changes, such as the Cordillera Central mountain range and the El Yunque rainforest.