bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Serum Vasohibin 1 Level Associated With the Development of Nephropathy in Diabetic Patients?
Authors: Sezal Didem Tutuncu , Seyithanoglu Muhammed , Sahin Murat , Ozturk Ilyas , Senel Mahmut Egemen , Erken Ertugrul , Gungor Ozkan , Altunoren Orcun 
Published: September 2020

Abstract
Background: Glomerular filtration surface area and glomerular filtration rate (GFR) are increased in patients with diabetic nephropathy, especially in the early phase of the disease. Glomerular neoangiogenesis contributes to this increased GFR. Increased GFR is associated with glomerular neoangiogenesis. Vasohibin-1 is an inhibitor of neoangiogenesis. The aim of this study is to evaluate serum vasohibin-1 levels of diabetic patients with and without diabetic nephropathy (DN). Methods: One hundred and five diabetic patients and 39 healthy controls matched for age and gender were included in the study. Diabetic patients with eGFR<60 ml/min/1,73m2 and/or those who had persistent proteinuria (>200 mg/gr) measured by urine protein/creatinine ratio (UP/C) were diagnosed as overt diabetic nephropathy (DN) if they haven’t any other known kidney diseases. Serum vasohibin-1 levels were measured by ELISA. Serum creatinine, eGFR, UP/C and vasohibin-1 levels were recorded.Results: Thirty-four percent of diabetic patients had DN. Systolic blood pressure and UP/C were higher in diabetic patients than healthy controls and age, sex, eGFR were similar. Diabetic patients have nonsignificantly lower serum vasohibin-1 levels than healthy controls. Patients with DN had higher UP/C, lower eGFR and long-standing diabetes compared to diabetic patients without nephropathy. Serum vasohibin-1 levels were similar between diabetic patients with and without DN. There was no correlation between vasohibin-1 levels and eGFR or UP/C.Conclusions: In this study for the first time we showed that diabetic patients have slightly lower vasohibin-1 levels than healthy subjects but there was no difference between diabetic patients with and without nephropathy in terms of serum vasohibin levels. Because, vasohibin-1 exhibits its anti-angiogenetic properties by acting via autocrine-paracrine pathways; local vasohibin activity at the tissue level may be more important than the circulating levels.
The Association of Clinical Characteristics With Cytogenetic Testing in Miscarriage Tissues: A Retrospective Review
Authors: Feng Chun , Yang Yan , Tao Xiao-Ling , Du Xin , Duan Jie 
Published: September 2020

Abstract
Background It is known little about to what extent the cytogenetic abnormalities association with clinical factors including maternal age, history of miscarriage, fertilization way and ultrasonographic finding in miscarriage tissues. A comprehensive investigation had informed to reveal the relevance of the profiles of these clinical factors of miscarriage with chromosomal abnormalities and propose feasible recommendations. Methods 478 cases of miscarriage tissue were performed by chromosomal microarray analysis between January 1, 2019, and December 31, 2019, the collected clinical data and the genetic findings were assessed using chi-squared analysis. Results 261 cases (54.7%) were identified as chromosomal abnormalities. Trisomy took place more frequency in advanced age of pregnancy women (p＜0.05), and it was closely related to the history of miscarriage. trisomy 16 (24.1%) was predominant in the ＜35 years group, whereas trisomy 15 (25.0%) was significantly more frequent in ≥35 years group. Trisomy 16, 15 and 13 were significantly more frequent in the first miscarriage, the second miscarriage and more than two times miscarriage, respectively. The positive rate in more than two times miscarriage in＜35 years group and ≥35 years group was 40.9% and 87.5%, respectively. More than two times miscarriages in ＜35 years was significantly difference with ≥35 years (P=0.02). Conclusion It is necessary to perform cytogenetic analysis to the miscarriage cases which are considered about the maternal age combined with history of miscarriage.
Design of a Motion Simulation System to Assist Respiratory Gating for Radiation Therapy
Authors: Wu Jian-Kuen , Chen Shih-Han , Hsu Feng-Ming , Liao Shu-Hsien , Wang Yu Jen 
Published: September 2020

Abstract
Background
Stereotactic ablative radiotherapy (SABR) aims to deliver high doses of radiation to kill cancer cells and shrink tumors in less than or equal to 6 fractions. However, organ motion during treatment is a challenging issue for this kind of technique. We develop a control system via Bluetooth technology to simulate and correct body motion during SABR.
Methods
Radiation doses were analyzed, and the radiation damage protection capability was checked by external beam therapy 3 (EBT3) films irradiated by a linear accelerator. A wireless signal test was also performed. A validation was performed with 8 previously treated patient respiratory pattern records and 8 healthy volunteers.
Results
The homemade simulation system consisted of 2 linear actuators, one movable stage with a maximal moving distance of 6.5 cm x 12.5 cm x 5 cm to simulate the respiratory pattern of 8 patients precisely with a median error of 0.36 mm and a maximal motion difference of 1.17 mm, and 3.17 and chipset transited signals to display them as a waveform. From the test with 8 volunteers, the chip could detect deep respiratory movement up to 3 cm. The effect of the chip on a radiation dose of 400 monitor units (MUs) by 6 MV photons and 200 MUs by 10 MV photons showed high penetration rates of 98.8% and 98.6%, respectively.
Conclusions
We invented a tubeless and wireless respiratory gating detection chip. The chip has minimal interference with the treatment angles, good noise immunity and the capability to easily penetrate a variety of materials. The simulation system consisting of linear actuators also successfully simulates the respiratory pattern of real patients.
Postoperative mortality among surgical patients with COVID-19: A systematic review and meta-analysis
Authors: Abate semagn , Mantefardo Bahiru , Basu Bivash 
Published: September 2020

Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic puts perioperative providers and staff at risk of viral exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during aerosol-generating procedures, particularly in asymptomatic carriers. However, the perioperative risk for adverse outcomes in SARS-CoV-2 infected patients remain uncertain and the topic of debate. The current study was designed to determine the postoperative mortality in COVID-19 patients based on a systematic review and meta-analysis of the global published peer-reviewed literature.Methods: A comprehensive search was conducted in PubMed/Medline; Science direct and LILACS from December 29, 2019, to August15, 2020, without language restriction. All observational studies reporting the prevalence of mortality were included while case reports and reviews were excluded. The data from each study were extracted with two independent authors with a customized format excel sheet and the disagreements were resolved by the third author. The methodological quality of included studies was evaluated using a standardized critical appraisal Tool adapted from the Joanna Briggs Institute.Results: A total of 715 articles were identified from different databases and 45 articles were selected for evaluation after the successive screening. Twenty-three articles with 2947 participants were included. The meta-analysis revealed a very high global rate of postoperative mortality among COVID-19 patients of 20% (95% CI: 15 to 26) and a postoperative ICU admission rate of 15% (95% confidence interval (CI):10 to 21). Conclusion: The unexpected high postoperative mortality rate in SARS-CoV-2 infected patients of 20% in the global literature mandates further scrutiny in assuring appropriate surgical indications and perioperative surgical safety measures in this vulnerable cohort of patientsRegistration: This systematic review and meta-analysis was registered in Prospero's international prospective register of systematic reviews (CRD42020203362) on August 10, 2020.
Weighted Gene Co-Expression Network Analysis to Construct Competitive Endogenous RNAs Network in Chromogenic Renal Cell Carcinoma
Authors: Chen Yon-Bo , Gao Liang , Tang Liang-You , Tian Yu-Chang , Tian Guan-Qiang , You PingHong 
Published: September 2020

Abstract
Background: This study aimed to construct the competing endogenous RNA (ceRNA) network in chromophobe renal cell carcinoma (ChRCC). Methods: Clinical and RNA sequence profiles of patients with ChRCC, including messenger RNAs (mRNAs), microRNAs (miRNAs), and long noncoding RNAs (lncRNAs), were obtained from The Cancer Genome Atlas (TCGA) database. “EdgeR” and “clusterProfiler” packages were utilized to obtain the expression matrices of differential RNAs (DERNAs) and to conduct gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Weighted gene co-expression network analysis (WGCNA) was performed to screen the highly related RNAs, and miRcode, StarBase, miRTarBase, miRDB, and TargetScan datasets were used to predict the connections between them. Univariate and multivariate Cox proportional hazards regressions were performed in turn to elucidate prognosis-related mRNAs in order to construct the ceRNA regulatory network. Results: A total of 1628 DElncRNAs, 104 DEmiRNAs, and 2619 DEmRNAs were identified. WGCNA showed significant correlation in 1534 DElncRNAs, 98 DEmiRNAs, and 2543 DEmRNAs, which were related to ChRCC. Fourteen DEmiRNAs, 113 DElncRNAs, and 43 DEmRNAs were screened. Nine mRNAs (ALPL, ARHGAP29, CADM2, KIT, KLRD1, MYBL1, PSD3, SFRP1, SLC7A11) significantly contributed to the overall survival (OS) of patients with ChRCC (P < 0.05). Furthermore, two mRNAs (CADM2, SFRP1) appeared to be independent risk factors for ChRCC. Conclusion: The findings revealed the molecular mechanism of ChRCC and potential therapeutic targets for the disease.
How FDI attracted? A Configurational Analysis for Regional Competitiveness in Mechanism of FDI Entry and Exit: Evidence from China
Authors: Zheng Yi 
Published: September 2020

Abstract
The economic benefits and spillover effects from FDI could lead accelerating the innovation of local economy and technological concept, which make it welcome in underdeveloped countries' authorities. This paper focuses on the entry and exit mechanism of FDI in 31 provinces of China from 2001 to 2016. The optimized diamond model associated with multi-theoretical cooperation is adopted to set up the regional competitiveness configuration for attracting FDI. It revealed that FDI attempts to enter regions with certain economic basis and favorable government conditions; but if the market fluctuates, even if there are favorable policy conditions, FDI will restructure because of their profit-seeking. Based on the conclusions, local governments can use the minimum resources to attract FDI in appropriate circumstances, and can optimize policies in time when it is not suitable for the entry and maintenance of FDI, so as to focus on develop local markets.
Sexual Assault Magnitude, Complications and Associated Factors among Females Who Visited Gynecologic Outpatient Department of Hawassa University Comprehensive Specialized Hospital
Authors: Ayele Abebaw Nigussie , Workneh Gelagay Zewudie , Gelaw Misganaw Worku 
Published: September 2020

Abstract
Background

Sexual assault is a major form of sexual violence affecting one out of every five women in the world. It is a complex problem with many consequences including sexually transmitted infections, posttraumatic stress disorder and risk of unintended pregnancy in reproductive-aged survivors of sexual assault.
Objective

To assess the magnitude, complication and factors associated with sexual assault among female visited gynecologic outpatient department of Hawassa University Comprehensive Specialized Hospital.
Methods

Cross sectional study was conducted from January 1 to October 30, 2019. Self-administered questionnaire developed using variables taken from WHO multi-country study on women health and from sexual violence medical evaluation certificate format were used to collect data. Descriptive analysis was done on sexual assault related characteristics and binary and multivariate logistic regression analysis were done to identify factors associated with sexual assault.
Results

399 clients were participated in the study and prevalence of sexual assault was 10.8% (43) of which 79.1% (34) of the victims were under the age of 18 years. 25% of the victims tested for pregnancy were positive and 7% (3) of each were positive for Hepatitis B and Trichomonas vaginalis. Age less than 18 years [AOR = 95.9, 95%CI (17.93, 512.96)], being single [AOR = 9.2, 95% CI (2.11, 40.42)], being in primary school [AOR = 18.0, 95% CI (1.63, 199.19)] and monthly income of < 1500 birr [AOR = 6.7, 95% CI (1.54, 29.50)] were significantly associated with sexual assault.
Conclusions

In this study, Age, marital status, monthly income and educational level were significantly associated with sexual assault.
Thoracoscopic Resection of Bilateral Multiple Superior Mediastinal Neurofibromas
Authors: Azuma Yoko , Tochigi Naobumi , Sano Atsushi , Sakai Takashi , Koezuka Satoshi , Otsuka Hajime , Iyoda Akira 
Published: September 2020

Abstract
Background: The indications for surgical resection concerning multiple bilateral neurofibromas in the superior mediastinum remain controversial, because vascular injury or development of postoperative Horne syndrome are concerned.Case presentation: A 60-year-old woman presented with multiple nodules in her right neck and bilateral chest cavity tops which indicated neurofibromatosis. The thoracic masses grew slowly over 9 years, and she then underwent a 2-stage resection starting with the left to right side. Bilateral tumors were completely removed via video-assisted thoracic surgery. The patient’s postoperative course was uneventful, without postoperative Horner syndrome. Conclusions: To the best of our knowledge, this is the first case of multiple bilateral superior mediastinal neurofibromas resected from the pulmonary apices via thoracoscopy. We selected a minimally invasive pure video-assisted thoracoscopic surgery approach and enucleated some tumors to avoid nerve injury. This approach may be safe and useful for multiple neurofibromas in patients with neurofibromatosis.
A New Method for Conservation of Ancient Colored Drawing on Hemp Textiles
Authors: Liu Jiaojiao , Li Yuhu , Xing Huiping , Hu Daodao , Chao Xiaolian , Cao Jing , Jia Zhihui 
Published: September 2020

Abstract
As a kind of textile, hemp artifact is a valuable cultural heritage. Suffering from several degradation factors in the preservation of cultural relics, some ancient hemp colored-paintings have been damaged, further affected their ornamental values. Therefore, it is urged to take the suitable conservation measures to protect the precious hemp artifacts for the historical culture succession. In this paper, an examination and analysis of the hemp colored paintings were the first step to propose an appropriate conservation treatment. Ultra-depth-of-field microscope was used to identify the kinds of fiber, and scanning electron microscope (SEM) was utilized to observe their condition and surface morphology. The element distribution and composition were identified by SEM, energy disperse spectroscopy (EDS) and X-ray fluorescence spectroscopy (XRF). Gas chromatography-mass spectrometer (GC-MS) was applied to identify the kinds of binding media and amino acid composition. Moreover, novel reinforcement materials and technology were proposed with the principle of compatibility and feasibility. The properties of tensile strength, aging resistance and chromatic aberration were tested before and after dry heat aging, wet heat aging and UV light aging. After systematic examination and evaluation of the hemp colored paintings and reinforcement materials, the optimal conservation treatment was finally established, and the Chinese hemp painting as an example has been protected successfully. This paper provides new methods and ideas for the restoration and protection of the linen cultural relics, which would promote the progress of protecting valuable cultural heritages.
Circulating Omentin-1, Insulin Resistance and Lipid Profile Responses Following 8-weeks Aerobic Training Intervention Among Smokers Vs. Non-smokers
Authors: Mousavi Seyed Maysam , Heidarianpour Ali , Tavassoli Hassan 
Published: September 2020

Abstract
Background: Omentin-1 is a recently circulating adipokine that plays a crucial role in modulating insulin resistance and diabetes. We investigated the effect of eight weeks aerobic exercise training on serum omentin-1, insulin resistance and lipid profile in the smoker and non-smokers with normal-weight. Methods: Nineteen healthy men and twenty smoker men were randomly assigned into healthy control group (C), healthy exercise group (E), control smoker group (CS) and exercise smoker group (ES). Exercise groups participated in an 8-weeks aerobic exercise training program (three times a week, 45 min per session at 65%-80% of maximum heart rate). Serum omentin-1 and insulin values were determined by ELISA and HOMA-IR, glucose and lipid profile were measured at pre and post of the intervention. Paired Sample t-test, one-way analysis of variance (One-way ANOVA) and post-hoc Tukey test were applied to analyze the data (p<0.05).Results: Aerobic exercise improved both serum omentin-1 and high lipoprotein cholesterol (HDL-C) in the exercise groups (p<0.05). Also, Exercise training reduced insulin, blood sugar, HOMA-IR, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels (p<0.05). Omentin-1 were significantly associated with insulin (r=-0.40, P=0.01), HOMA-IR (r=-0.38, P=0.04), TG (r=-0.40, P=0.01), TC (r=-0.49, P=0.02), LDL-C (r=-0.70, P=0.02) and HDL-C (r=0.55, P=0.03).Conclusion: The findings suggest that aerobic exercise-induced changes in omentin-1 in exercise trained smokers may be associated with the beneficial effects of exercise on reduced insulin and lipid profile.
Development and Validation of an Immune-Related Gene-Pair Model of High-Grade Serous Ovarian Cancer After Platinum-Based Chemotherapy
Authors: Lin Jiaxing , Sun Dan , Li Tianren 
Published: September 2020

Abstract
Background: High-grade serous ovarian cancer (HGSOC) is a common cause of death from gynecological cancer, with an overall survival rate that has not significantly improved in decades. Reliable bio-markers are needed to identify high-risk HGSOC to assist in the selection and development of treatment options.Method: The study included ten HGSOC cohorts, which were merged into four separate cohorts including a total of 1526 samples. We used the relative expression of immune genes to construct the gene-pair matrix, and the Least absolute shrinkage and selection operator regression was performed to build the prognosis model using the training set. The prognosis of the model was verified in the training set (363 cases) and three validation sets (of 251, 354, and 558 cases). Finally, the differences in immune cell infiltration and gene enrichment pathways between high and low score groups were identified.Results: A prognosis model of HGSOC overall survival rate was constructed in the training set, and included data for 35 immune gene-related gene pairs and the regression coefficients. The risk stratification of HGSOC patients was successfully performed using the training set, with a p-value of Kaplan-Meier of < 0.001. A score from this model is an independent prognostic factor of HGSOC, and prognosis was evaluated in different clinical subgroups. This model was also successful for the other three validation sets, and the results of Kaplan-Meier analysis were statistically significant. The model can also predict patient progression-free survival with HGSOC to reflect tumor growth status. There were differences in some immune cells between the high-risk and low-risk groups as defined by the model. There was a lower infiltration level of M1 macrophages in the high-risk group compared to that in the low-risk group (p < 0.001). Finally, many of the immune-related pathways were enriched in the low-risk group, with antigen processing and presentation identified as the most enriched pathways.Conclusion: The prognostic model based on immune-related gene pairs developed is a potential prognostic marker for high-grade serous ovarian cancer treated with platinum. The model has robust prognostic ability and wide applicability. More prospective studies will be needed to assess the practical application of this model for precision therapy.
Long Non-Coding RNA-DUXAP8 Regulates TOP2A in the Growth and Metastasis of Osteosarcoma via MicroRNA-635
Authors: Yang Ting , Quo Jian Ping , Li Fan , Xiu Chao , Wang Hua , Duan Xian Liang 
Published: September 2020

Abstract
Purpose: Osteosarcoma (OS) is a malignant tumor disease with high morbidity and mortality in children and adolescents. Evidence indicates that long non-coding RNAs (lncRNAs) may be important players in human cancer progression, including OS. In this study, we identified the role of lnc-DUXAP8 in the development of OS.Materials and Methods: Expression of lncRNA DUXAP8 was determined by real-time quantitative PCR and Western blotting in OS tissues. Cell proliferation was evaluated using CCK8 and colony formation assay; Transwell assay was conducted to measure cell invasion. Cell migration was evaluated using Wound Healing assay. The binding site between the lnc-DUXAP8 and miR-635 RNAs was evaluated using a luciferase reporter assay. Results: The expression of the lnc-DUXAP8 was significantly upregulated in OS samples and OS cell lines compared to normal tissue. High expression of lncRNA DUXAP8 was associated with shorter overall survival. Knockdown of lncRNA DUXAP8 inhibited proliferation and migration, and invasion in OS cells. More importantly, mechanism investigation revealed that lncRNA DUXAP8 was predominantly acted as a competing endogenous RNA (ceRNA) in OS by regulating miR-635/ TOP2A axis. Conclusion: LncRNA DUXAP8 is upregulated in OS, and LncRNA DUXAP8 knockdown plays a vital anti-tumor role in OS cell progression through a miR-635/ TOP2A axis. Our study suggests that LncRNA DUXAP8 may be a novel, promising biomarker for diagnosis and prognosis of OS.