bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kredibilitas Influencer Dan Kesadaran Merek Terhadap Minat Beli Produk Hanasui
Authors: Suryati Enden , Bahtiar Dandi , Rohimah Dwi Laila 
Published: December 2024

Penelitian ini dilakukan bertujuan untuk melihat bagaimana Pengaruh Kredibilitas Influencer, Kesadaran Merek dan Minat Beli produk Hanasui pada Mahasiswi Universitas Putra Indonesia. Bagaimana Pengaruh Kredibilitas Influencer dan Kesadaran Merek terhadap Minat Beli produk Hanasui dan apa saja faktor yang menghambat Minat Beli produk Hanasui pada Mahasiswi Universitas Putra Indonesia. Metode penelitian menggunakan pendekatan kuantitatif dengan menyebarkan kuesioner secara online maupun offline kepada Mahasiswi Universitas Putra Indonesia. Populasi yang digunakan dalam penelitian ini adalah Mahasiswa Universitas Putra Indonesia sebanyak 699 orang dengan jumlah samprel sebesar 87 orang. Teknik sampling penelitian ini menggunakan teknik purposeful sampling. Teknik analisis data yang digunakan adalah regresi linear berganda, uji t, uji F dan uji determinasi ( dengan menggunakan SPSS 26. Adapun hasil dari penelitian ini menunjukkan bahwa Kredibilitas Influencer ( ) secara parsial berpengaruh signifikan terhadap Minat Beli (Y) dan Kesadaran Merek ) secara parsial berpengaruh positif dan signifikan terhadap variabel Minat Beli (Y). kemudian Kredibilitas Influencer ( ) dan Kesadaran Merek ( ) secara simultan berpengaruh positif dan signifikan terhadap Minat Beli. Nilai koefisien determinasi ( yang diperoleh sebesar 66,1% terhadap Minat Beli (Y) produk Hanasui yang dipengaruhi oleh Kredibilitas Influencer ( ) dan Kesadaran Merek ). Sisanya sebesar 33,9% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.
Sertifikasi Halal Produk Untuk Peningkatan Daya Saing Usaha Pada UMK di Desa Ciseeng
Authors: Ismail Verni Yuliaty , Annisa Intan Tri , Roswiem Anna P 
Published: December 2024

Populasi penduduk muslim di indonesia merupakan potensi konsumen produk makanan yang besar. Pemilikan sertifikat halal produk memberi nilai tambah bagi pelaku usaha untuk memproduksi dan menjual produk halal agar sesuai dengan perilaku konsumen muslim yang memiliki value untuk mengkonsumsi produk halal. Disamping itu adanya ketentuan dari pemerintah tentang kewajiban sertifikat halal produk makanan dan minuman bagi pelaku UMKM. Desa Ciseeng yang terletak di Kabupaten Bogor Jawa Barat memiliki banyak UMK yang memproduksi makanan dan relatif masih terbatas yang sudah memiliki sertifikat halal produk. Tujuan Kegiatan Pengabdian kepada Masyarakat ini adalah mengembangkan potensi UMK di Wilayah Ciseeng dalam meningkatkan daya saing usaha produk makanan. Salah satu Upaya tersebut adalah melalui penerbitan sertifikat halal produk makanan UMK. Minimnya literasi pelaku UMK tentang kriteria produk halal dan prosedur pengurusan sertifikat halal produk menjadi kendala bagi pelaku UMK untuk mendapatkan sertifikat halal produk mereka. Solusi yang ditawarkan oleh Lembaga Pengabdian Masyarakat Universitas YARSI adalah dengan memberikan edukasi tentang produk halal, workshop tentang tatacara sertifikasi halal produk self-declare, dan pendampingan pendaftaran langsung pada Sistem Informasi Halal (SIHALAL). Hasil kegiatan adalah diperolehnya peningkatan pemahaman tentang produk halal, dan dari 15 pelaku UMK produk makanan yang mendaftar sertifikat halal produk, 8 sertifikat halal produk telah terbit dari BPJPH
Improvement of tinnitus, anxiety, and depression following cochlear implant surgery: a prospective cohort study
Authors: Lamounier Pauliana , Gonçalves Victória Franco , Queiroz Isabela Carvalho , Gobbo Débora Aparecida , Bernardes Marina Nahas Dafico , Costa Claudiney Cândido , Ramos Hugo Valter Lisboa , Bahmad Fayez 
Published: December 2024

IntroductionHearing loss affects ~1. 5 billion people worldwide and is the greatest risk factor for tinnitus, a condition that can further worsen people's quality of life, lead to high anxiety and depression, and affect general health and wellbeing.ObjectivesThis study aimed to assess the impact of cochlear implants (CIs) on tinnitus perception and quality of life and their relationship with psychological disorders, such as depression and anxiety.MethodsThirty adults with profound bilateral hearing loss who were candidates for CI surgery and experienced tinnitus were assessed using the Tinnitus Handicap Inventory (THI), the Visual Analog Scale (VAS), the World Health Organization Quality of Life Instruments–Bref (WHOQOL-BREF), and the Hospital Anxiety and Depression Scale questionnaires at four different time points: preoperatively, 7 days after cochlear implant activation, and 3 and 6 months after cochlear implant surgery. The International Outcome Inventory CI was applied at 3 and 6 months, and the Glasgow Benefit Inventory (GBI) questionnaire was applied at 6 months.ResultsThe VAS and THI scores improved; however, significant improvements were only observed in the THI scores 6 months post-surgery. Time spent using hearing aids did not correlate significantly with speech recognition test scores, nor were the changes in the preoperative THI score and VAS scores or the changes in the speech recognition test scores 6 months post-surgery significantly correlated. We observed a decrease in anxiety and depression scores at the 6-month follow-up compared to the preoperative period.ConclusionThe THI scores significantly increased after CI surgery, suggesting that the tinnitus had improved. Improved anxiety and depression scores after CI surgery were also observed. The WHOQOL-BREF quality-of-life self-evaluation scores, as well as the environment and general domains, significantly improved as well.
Development and clinical validation of passive shoulder exoskeleton with novel gravity compensation mechanism for stabilizing arm tremor of surgeons during minimally invasive surgery
Authors: Choi Ho Seon , Lee Seung Jun , In Hyunki 
Published: December 2024

IntroductionDuring tasks like minimally invasive surgery (MIS), various factors can make working environment not be ergonomic, and those situations will accumulate fatigue in the surgeon's muscles which will inevitably lead to poor surgical performance. Therefore, there has been a need for technical solutions to solve this problem and one of the methods is exoskeleton robots.MethodsWe designed a passive shoulder exoskeleton whose workspace could be used for MIS to assist the surgeon's movements and performed computational and clinical validation. First, the joint order of the shoulder exoskeleton, which consists of three degrees of freedom, was configured differently from previous studies so that the singularity can be located outside the workspace. And a novel gravity compensation mechanism was developed to replace the existing one, which could no longer be used due to these changes on order of joints. Afterwards, it was computationally verified using statics and kinematics whether sufficient shoulder muscle assistance could be implemented for the entire developed system. Lastly, we manufactured an apparatus that simulated the surgical environment in which the shoulder exoskeleton robot would actually be used, recruited human participants, and conducted an experiment.ResultsThrough computational validation, we can guess that the developed shoulder exoskeleton can provide 18.14% reduction of muscle activation to the wearers in workspace. And the results of clinical experiments with human subjects show that activation of deltoid posterior, medial and anterior decreased with average −8.33%, −14.55%, and −21.0%, respectively during MIS-simulated tasks with developed shoulder exoskeleton than without it. And arm tremor which is equals to movement variability also decreased with average 9.85% by using shoulder exoskeleton and maximum −19.5% in a certain position.DiscussionThese experimental results show that our shoulder exoskeleton and its novel gravity compensation mechanism has enough clinical effectiveness for workers of underhead tasks, especially surgeons who conduct MIS. It reduced deltoid activations of wearers and also stabilized arm tremor which are directly related to performance of fine manipulative task, so that this research implies that shoulder exoskeletons are also need for underhead tasks and our shoulder exoskeleton has possibility to contribute to those utilities.
Effects and safety of propofol intravenous anesthesia in transvaginal oocyte retrieval on outcomes of in vitro fertilization and embryo transplantation
Authors: Liu Xiao-Ming , Zhang Fan , Lu Xiao-Sheng , Xi Hai-Tao , Zhao Jun-Zhao 
Published: December 2024

PurposePropofol, a widely utilized anesthetic, is employed to alleviate pain and anxiety in outpatient oocyte retrieval procedures. However, its potential impact and safety profile in the context of in vitro fertilization and embryo transfer (IVF-ET) remain unclear.MethodsThis retrospective study enrolled 1187 patients undergoing IVF-ET, and divided into two groups depending on whether they received propofol (propofol group, n=140) or not (control group, n=1047) for anesthesia during oocyte retrieval.ResultsThe baseline characteristics were comparable between the groups. Compared with control group, the number of oocytes retrieved in propofol group was more (p=0.012), while both the estradiol (E2) level on the trigger day and the pre-ovulatory follicle count were higher in propofol group ((p&lt;0.01). Additionally, the rate of preterm delivery was significantly higher in the propofol group (p&lt;0.001). To further analyze the effect of propofol on the oocyte retrieval rate, patients were divided into three subgroups depending on the pre-ovulatory follicle count (≤10, 11–20, and &gt;20) to eliminate the influence of inconsistency in the estimation of the pre-ovulatory follicle count between the two groups. Analysis revealed that the use of propofol during oocyte retrieval was particularly advantageous in the subgroup with a pre-ovulatory follicle count of 11–20, yielding a higher oocyte retrieval rate (p&lt;0.001).ConclusionThe use of propofol in oocyte retrieval did not adversely affect fertilization, embryo quality, or clinical outcomes. Moreover, it was found to increase the oocyte retrieval rate among patients with an estimated pre-ovulatory follicle count of 11–20. These findings offer valuable evidence supporting the clinical application of propofol in oocyte retrieval procedures.
Methodological approaches to survey complex ice cave environments - the case of Dobšiná (Slovakia)
Authors: Pukanská Katarína , Bartoš Karol , Gašinec Juraj , Pašteka Roman , Zahorec Pavol , Papčo Juraj , Bella Pavel , Andrássy Erik , Dušeková Laura , Bobíková Diana , Kseňak Ľubomír 
Published: December 2024

IntroductionDobšiná Ice Cave (Slovakia) has attracted the attention of many researchers since its discovery more than 150 years ago. Although the cave is located outside the high-mountain area, it hosts one of the largest volumes of underground perennial ice. The topographic mapping of this unique UNESCO Natural Heritage site has led to several historical surveys. In the last decades of rapid climate change, this natural formation has been subject to rapid changes that are dynamically affecting the shape of the ice body. Increased precipitation, the rise in year-round surface temperatures, and the gravity cause significant shape changes in the ice filling.MethodsThis paper describes modern technological tools to comprehensively survey and evaluate interannual changes in both the floor and wall of the underground ice body. Technologies such as digital photogrammetry, in combination with precise digital tacheometry and terrestrial laser scanning, make it possible to detect ice accumulation and loss, including the effect of sublimation due to airflow, as well as sliding movements of the ice body to the lower part of the cave. To get a comprehensive model of the ice volume, geophysical methods (microgravimetry and ground penetrating radar) have been added to determine the thickness of the floor ice in the upper parts of the cave in the last 2 years.ResultsBetween 2018 and 2023, the ice volume in certain sections of the cave decreased by up to 667 m³, with notable reductions in ice thickness ranging from 0.3 to 0.9 m in areas like the Small Hall and Collapsed Dome. The study also detected dynamic changes, such as the widening of the ice tunnel by 20 cm in some sections, and a vertical ice wall in Ruffinyi’s Corridor showed localized volume losses up to 9 m3 (between 2018 and 2023). Additional geophysical methods - microgravimetry and ground penetrating radar - revealed an average ice thickness ranging from 10 to 25 m.DiscussionThe paper not only highlights the current technological possibilities but also points out the limitations of these technologies and then sets out solutions with a proposal of technological procedures for obtaining accurate geodetic and geophysical data.
Stem cell graft dose and composition could impact on the expansion of donor-derived clones after allogeneic hematopoietic stem cell transplantation – a virtual clinical trial
Authors: Stiehl Thomas 
Published: December 2024

IntroductionHematopoietic stem cell transplantation is a potentially curative intervention for a broad range of diseases. However, there is evidence that malignant or pre-malignant clones contained in the transplant can expand in the recipient and trigger donor-derived malignancies. This observation has gained much attention in the context of clonal hematopoiesis, a medical condition where significant amounts of healthy blood cells are derived from a small number of hematopoietic stem cell clones. In many cases the dominating clones carry mutations conferring a growth advantage and thus could undergo malignant transformation in the recipient. Since clonal hematopoiesis exists in a significant proportion of potential stem cell donors, a more detailed understanding of its role for stem cell transplantation is required.MethodsWe propose mechanistic computational models and perform virtual clinical trials to investigate clonal dynamics during and after allogenic hematopoietic stem cell transplantation. Different mechanisms of clonal expansion are considered, including mutation-related changes of stem cell proliferation and self-renewal, aberrant response of mutated cells to systemic signals, and self-sustaining chronic inflammation triggered by the mutated cells.ResultsModel simulations suggest that an aberrant response of mutated cells to systemic signals is sufficient to explain the frequently observed quick expansion of the mutated clone shortly after transplantation which is followed by a stabilization of the mutated cell number at a constant value. In contrary, a mutation-related increase of self-renewal or self-sustaining chronic inflammation lead to ongoing clonal expansion. Our virtual clinical trials suggest that a low number of transplanted stem cells per kg of body weight increases the transplantation-related expansion of donor-derived clones, whereas the transplanted progenitor dose or growth factor support after transplantation have no impact on clonal dynamics. Furthermore, in our simulations the change of the donors’ variant allele frequencies in the year before stem cell donation is associated with the expansion of donor-derived clones in the recipient.DiscussionThis in silico study provides insights in the mechanisms leading to clonal expansion and identifies questions that could be addressed in future clinical trials.
Impact of inhibitory KIR ligand mismatch and other variables on outcomes following myeloablative posttransplant cyclophosphamide-based T-cell-replete haploidentical bone marrow transplantation
Authors: Kayser Sarah , Salzmann-Manrique Emilia , Serve Hubert , Bader Peter , Klusmann Jan-Henning , Seidl Christian , Schwäble Joachim , Bug Gesine , Ullrich Evelyn 
Published: December 2024

IntroductionPosttransplant cyclophosphamide (PTCy) has revolutionized the landscape of human leukocyte antigen (HLA)-haploidentical hematopoietic cell transplantation (haplo-HCT), providing a pivotal therapeutic option for patients with hematological malignancies who lack an HLA-matched donor.MethodsIn this retrospective analysis involving 54 adult patients undergoing PTCy-based haplo-HCT, we evaluated the impact of inhibitory killer immunoglobulin-like receptor (KIR)/HLA mismatch, alongside patient, donor, and transplant factors, on clinical outcomes within a homogeneous cohort characterized by a myeloablative conditioning regimen and bone marrow graft.ResultsWith a median follow-up of 73.2 months, our findings reveal promising outcomes: 6-year overall survival, relapse-free survival, and graft-versus-host disease (GVHD) and relapse-free survival rates were 63% (95% CI: 51–79), 58% (95% CI: 46–74), and 42% (95% CI: 30–58), respectively. Notably, the cumulative incidence rates of relapse and non-relapse mortality at 6 years post-haplo-HCT were 29% (95% CI: 19–45) and 12% (95% CI: 6–26), respectively. Acute GVHD at day 100 posttransplantation occurred with a cumulative incidence of 33% (95% CI: 22– 49) for grades II–IV and 9% (95% CI: 3–23) for grades III–IV. Furthermore, 41% of patients developed chronic GVHD within 1 year posttransplantation, distributed as follows: 28% mild, 9% moderate, and 4% severe.ConclusionWithin our cohort, several variables were associated with outcomes following PTCy-based haplo-HCT. However, inhibitory KIR/HLA mismatch did not influence these outcomes.
Metformin improves Mycobacterium avium infection by strengthening macrophage antimicrobial functions
Authors: Mediaas Sindre Dahl , Haug Markus , Louet Claire , Wahl Sissel Gyrid Freim , Gidon Alexandre , Flo Trude Helen 
Published: December 2024

IntroductionThe incidence and prevalence of infections with non-tuberculous mycobacteria such as Mycobacterium avium (Mav) are increasing. Prolonged drug regimens, inherent antibiotic resistance, and low cure rates underscore the need for improved treatment, which may be achieved by combining standard chemotherapy with drugs targeting the host immune system. Here, we examined if the diabetes type 2 drug metformin could improve Mav-infection.MethodsMetformin was administered to C57BL/6 mice infected intranasally with Mav and C57BL/6 mice were infected intranasally with Mav and treated with metformin over 3 weeks. Organ bacterial loads and lung pathology, inflammatory cytokines and immune cell profiles were assessed. For mechanistic insight, macrophages infected with Mav were treated with metformin alone or in combination with inhibitors for mitochondrial ROS or AMPK and assessed for bacterial burden and phagosome maturation.Results and discussionThree weeks of metformin treatment significantly reduced the lung mycobacterial burden in mice infected with Mav without major changes in the overall lung pathology or immune cell composition. Metformin treatment had no significant impact on tissue inflammation except for a tendency of increased lung IFNγ and infiltration of Mav-specific IFNγ-secreting T cells. Metformin did, however, boost the antimicrobial capacity of infected macrophages directly by modulating metabolism/activating AMPK, increasing mitochondrial ROS and phagosome maturation, and indirectly by bolstering type I immunity. Taken together, our data show that metformin improved the control of Mav-infection in mice, mainly by strengthening antimicrobial defenses in macrophages, and suggest that metformin has potential as an adjunct treatment of Mav infections.
Case report: Long-term response to a combination of immune checkpoint inhibitors as a single treatment for multiple synchronous cancers: a case study
Authors: Ghammem Nour , Bischoff Herve , Chiappa Pascale , Somme Laura , Moinard-Butot Fabien 
Published: December 2024

IntroductionImmune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by enhancing the antitumor immune response. This case describes an 80-year-old male with synchronous multiple primary malignancies (MPMs), including lung metastatic hepatocellular carcinoma (HCC), and non-small cell lung carcinoma (NSCLC), and brain metastatic urothelial carcinoma, who was treated with dual ICI therapy.Case presentationThe patient, with a history of diabetes, hypertension, dyslipidaemia, well-differentiated neuroendocrine duodenal tumors and micronodular exogenous cirrhosis (Child-Pugh class A), presented with a non-invasive bladder carcinoma (pT1N0M0) resected endoscopically in December 2022. Incidentally discovered hepatic and pulmonary tumors were confirmed as primary HCC and squamous cell carcinoma of the lung (cT1bN0M0, PD-L1 expression 100%), respectively. Due to the rapid progression of pulmonary metastases secondary to HCC, dual ICI therapy (durvalumab and tremelimumab) was initiated, resulting in a partial response (&gt;30%) according to RECISTv1.1 criteria in pulmonary and hepatic lesions. After one year of ICI therapy, cerebellar syndrome due to secondary brain lesions emerged, which was confirmed as urothelial metastases. Surgical resection of the symptomatic cerebral metastases was completed with cerebral radiotherapy, and ICIs were continued. The patient is still receiving dual ICIs.DiscussionThis case highlights the crucial role of ICIs in treating MPMs. The patient’s favourable response suggests the importance of PD-L1 expression as a predictive biomarker.ConclusionThis rare case showed dual ICI therapy efficacy across multiple malignancies. Effective multidisciplinary collaboration and biomarker evaluation are crucial for managing such complex cases.
Perceived training needs by tutors of family and community medicine and nursing of specialized health training: a qualitative descriptive study
Authors: Berlanga-Fernández Sofía , Rodríguez-Monforte Miriam , Pérez-Cañaveras Rosa M. , Valer-Martínez Alicia , Copetti-Fanlo Silvia , Simonet-Aineto Pere J. , Vizcaya-Moreno Flores , Villafáfila-Ferrero Rosa 
Published: December 2024

IntroductionSpecialized Health Training is a postgraduate training pathway in which physicians and nurses can choose to continue their learning and obtain the qualification of specialist professional in a specific field. The training is eminently practical with different clinical tracks in which nurses and physicians are tutored by clinician tutors. Our research aims to describe the experiences and perceptions of clinician tutors related to their own teaching performance and training needs.MethodsWe conducted a descriptive qualitative study. The sample consisted of active clinician tutors of specialized health training of family and community nursing and medicine, this being the main inclusion criterion, regardless of the number of years of experience as a tutor. Data were analyzed following a content analysis method.ResultsFour focus groups were held with 25 participants: 32% nursing tutors (8) and 68% tutors of medicine (17). The main categories identified were: (1) teaching performance; (2) training needs; and (3) characteristics of an ideal training program. The sample consisted of a majority of tutors of medicine compared to nursing.ConclusionClinician tutors of Specialized Health Training of Family and Community nursing and medicine express the need to acquire pedagogical tools, to develop communication skills and to create a tutor network in order to improve their mentorship practice. Furthermore, more institutional recognition and protected time are also highlighted as important elements for their mentorship role. The findings of our research can serve as a guideline to start designing a training plan that meets the real needs of clinician tutors.