bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apoptotic exosome-like vesicles regulate endothelial gene expression, inflammatory signaling, and function through the NF-κB signaling pathway
Authors: Migneault Francis , Dieudé Mélanie , Turgeon Julie , Beillevaire Déborah , Hardy Marie-Pierre , Brodeur Alexandre , Thibodeau Nicolas , Perreault Claude , Hébert Marie-Josée 
Published: July 2020

AbstractPersistent endothelial injury promotes maladaptive responses by favoring the release of factors leading to perturbation in vascular homeostasis and tissue architecture. Caspase-3 dependent death of microvascular endothelial cells leads to the release of unique apoptotic exosome-like vesicles (ApoExo). Here, we evaluate the impact of ApoExo on endothelial gene expression and function in the context of a pro-apoptotic stimulus. Endothelial cells exposed to ApoExo differentially express genes involved in cell death, inflammation, differentiation, and cell movement. Endothelial cells exposed to ApoExo showed inhibition of apoptosis, improved wound closure along with reduced angiogenic activity and reduced expression of endothelial markers consistent with the first phase of endothelial-to-mesenchymal transition (endoMT). ApoExo interaction with endothelial cells also led to NF-κB activation. NF-κB is known to participate in endothelial dysfunction in numerous diseases. Silencing NF-κB reversed the anti-apoptotic effect and the pro-migratory state and prevented angiostatic properties and CD31 downregulation in endothelial cells exposed to ApoExo. This study identifies vascular injury-derived extracellular vesicles (ApoExo) as novel drivers of NF-κB activation in endothelial cells and demonstrates the pivotal role of this signaling pathway in coordinating ApoExo-induced functional changes in endothelial cells. Hence, targeting ApoExo-mediated NF-κB activation in endothelial cells opens new avenues to prevent endothelial dysfunction.
Serum interleukin 17A and interleukin 17F in children with inflammatory bowel disease
Authors: Krawiec Paulina , Pac-Kożuchowska Elżbieta 
Published: July 2020

AbstractInterleukin 17A (IL-17A) and interleukin 17F (IL-17F) appear to play important role in pathogenesis of some autoimmune diseases. However, their role in inflammatory bowel disease (IBD) has not been yet fully elucidated. We aimed to determine serum IL-17A and IL-17F in children with IBD and to assess their association with IBD activity. Recruited children underwent blood tests including complete blood count, C-reactive protein, erythrocyte sedimentation rate, IL-17A and IL-17F and stool sampling for calprotectin. The study group comprised 68 children with IBD, including 43 with ulcerative colitis and 25 with Crohn’s disease. Control group included 20 healthy children. IL-17A was significantly increased in children with IBD (median: 10.95 pg/ml; range: 0.65–200.54 pg/ml) compared to controls (median: 4.09 pg/ml; range: 0.67–26.20 pg/ml) (p = 0.002). IL-17A was significantly increased in patients with active phase of ulcerative colitis (median: 14.58 pg/ml; range: 0.65–200.54 pg/ml) compared to those in ulcerative colitis remission (median: 8.13 pg/ml; range: 1.61–58.56 pg/ml) (p = 0.04). There were no significant differences in IL-17A among patients with active and inactive Crohn’s disease (p = 0.18). IL-17F did not differ significantly between children with IBD (median: 15.11 pg/ml; range: 0.09–189.84 pg/ml) and controls (median: 11.56 pg/ml; range: 0.19–32.49 pg/ml) (p = 0.33). Our study suggests that interleukin 17A may diverse active phase from remission only in ulcerative colitis but not in Crohn’s disease.
Multi-group analysis using generalized additive kernel canonical correlation analysis
Authors: Bae Eunseong , Hur Ji-Won , Kim Jinyoung , Kwon Jun Soo , Lee Jongho , Lee Sang-Hun , Lim Chae Young 
Published: July 2020

AbstractMultivariate analysis has been widely used and one of the popular multivariate analysis methods is canonical correlation analysis (CCA). CCA finds the linear combination in each group that maximizes the Pearson correlation. CCA has been extended to a kernel CCA for nonlinear relationships and generalized CCA that can consider more than two groups. We propose an extension of CCA that allows multi-group and nonlinear relationships in an additive fashion for a better interpretation, which we termed as Generalized Additive Kernel Canonical Correlation Analysis (GAKCCA). In addition to exploring multi-group relationship with nonlinear extension, GAKCCA can reveal contribution of variables in each group; which enables in-depth structural analysis. A simulation study shows that GAKCCA can distinguish a relationship between groups and whether they are correlated or not. We applied GAKCCA to real data on neurodevelopmental status, psychosocial factors, clinical problems as well as neurophysiological measures of individuals. As a result, it is shown that the neurophysiological domain has a statistically significant relationship with the neurodevelopmental domain and clinical domain, respectively, which was not revealed in the ordinary CCA.
Respiratory microbiota of humpback whales may be reduced in diversity and richness the longer they fast
Authors: Vendl Catharina , Slavich Eve , Wemheuer Bernd , Nelson Tiffanie , Ferrari Belinda , Thomas Torsten , Rogers Tracey 
Published: July 2020

AbstractHumpback whales endure several months of fasting while undertaking one of the longest annual migrations of any mammal, which depletes the whales’ energy stores and likely compromises their physiological state. Airway microbiota are linked to respiratory health in mammals. To illuminate the dynamics of airway microbiota in a physiologically challenged mammal, we investigated the bacterial communities in the blow of East Australian humpback whales at two stages of their migration: at the beginning (n = 20) and several months into their migration (n = 20), using barcoded tag sequencing of the bacterial 16S rRNA gene. We show that early in the fasting the whale blow samples had a higher diversity and richness combined with a larger number of core taxa and a different bacterial composition than later in the fasting. This study provides some evidence that the rich blow microbiota at the beginning of their fasting might reflect the whales’ uncompromised physiology and that changes in the microbiota occur during the whales’ migration.
Wearable radio-frequency sensing of respiratory rate, respiratory volume, and heart rate
Authors: Sharma Pragya , Hui Xiaonan , Zhou Jianlin , Conroy Thomas B. , Kan Edwin C. 
Published: July 2020

AbstractMany health diagnostic systems demand noninvasive sensing of respiratory rate, respiratory volume, and heart rate with high user comfort. Previous methods often require multiple sensors, including skin-touch electrodes, tension belts, or nearby off-the-body readers, and hence are uncomfortable or inconvenient. This paper presents an over-clothing wearable radio-frequency sensor study, conducted on 20 healthy participants (14 females) performing voluntary breathing exercises in various postures. Two prototype sensors were placed on the participants, one close to the heart and the other below the xiphoid process to couple to the motion from heart, lungs and diaphragm, by the near-field coherent sensing principle. We can achieve a satisfactory correlation of our sensor with the reference devices for the three vital signs: heart rate (r = 0.95), respiratory rate (r = 0.93) and respiratory volume (r = 0.84). We also detected voluntary breath-hold periods with an accuracy of 96%. Further, the participants performed a breathing exercise by contracting abdomen inwards while holding breath, leading to paradoxical outward thorax motion under the isovolumetric condition, which was detected with an accuracy of 83%.
Social-Media-Marketing: Ohne geht es nicht!
Authors: Lehwald Andrea 
Published: July 2020

ZusammenfassungWer heutzutage der Öffentlichkeit sein Unternehmen präsentieren möchte oder auf der Suche nach neuen Mitarbeitern ist, der kommt um das Thema Social-Media nicht herum. Die verschiedenen Plattformen sind inzwischen fester Bestandteil der Unternehmenskommunikation.
Aktiv in der Verbandsarbeit
Authors: Lukuc Sarah 
Published: July 2020

ZusammenfassungDa heißt es oft, junge Menschen engagieren sich zu wenig. In der Arbeitsgruppe Nachwuchs Pflegemanagement im Bundesverband Pflegemanagement sieht das anders aus. Lesen Sie mehr zu den motivierten Zielen der AG im Erfahrungsbericht von Vorstandsmitglied Sarah Lukuc.
The rise and fall of viticulture in the Late Antique Negev Highlands reconstructed from archaeobotanical and ceramic data
Authors: Fuks Daniel , Bar-Oz Guy , Tepper Yotam , Erickson-Gini Tali , Langgut Dafna , Weissbrod Lior , Weiss Ehud 
Published: July 2020

Significance
Commercial production of luxury “Gaza wine” was long assumed to be the economic basis of Late Antique settlement in the Negev Desert. We present empirical evidence for local viticulture of scale and its connection to Mediterranean trade. Offering unprecedented testimony to the globalization of an ancient production economy in a marginal environment, our archaeobotanical and ceramic dataset illuminates the rise and fall of local viticulture in the fourth to sixth centuries of the common era (CE). Decline likely resulted from market contraction triggered by plague and climate change rather than Islamic conquest, exposing systemic vulnerabilities of Negev agricultural commercialization. In millennial-scale Negev history, the Late Antique commercial florescence is anomalous, lasting about two centuries before reverting to smaller settlement and survival–subsistence strategies.
The Development of Interactive E-book of Teaching Indonesian for Speaker of Other Language (TISOL) Containing Local Wisdom with Scientific-Thematic Approach
Authors: Saddhono K , Ridwan M , Suherman A , Anwar K , Putri N Q H 
Published: July 2020

Abstract
TISOL learning definitely needs to notice planning, processes, evaluations, learning materials, media, and methods used. However, selecting the media and learning material should give foreign students the description about Indonesia condition so that can lead them to be more interested in learning Indonesian language. This study was a developmental research aiming to apply a model of the local wisdom-based interactive book for TISOL students in Indonesia. The research stages are applied 4 stages, namely (1) preliminary study or exploration, (2) prototype development, (3) prototype test, and (4) dissemination or product implementation. The location of this study was institutions which organizing TISOL in Indonesia. This study was planned to be conducted in 3 years to get data as a reference for the product development and implementation in term of the interactive e-book. Sources of data were (1) TISOL students, instructors, organizers and persons in charge; (2) TISOL teaching-learning activities in TISOL institution; (3) data which obtained through questionnaire containing questions to emphasize the result of the exploration, and (4) textbooks used by BIPA institutions and also learning curricula. After passing some assessment, such as expert assessment, small-scale and wide-scale tests, and experiment class test, interactive e-book for TISOL learning conducted in high level score. Therefore, it can be said that the use of TISOL interactive e-book on learning process as a variation in giving learning materials in TISOL. It can be also considered as an input for TISOL learning developers to give innovation on their products developed.
The effect of work environment and social security on employees’ productivity of production department in textile industry
Authors: Ratnasahara Elisabeth Damarsari , Suyono Joko , Sukaris  
Published: July 2020

Abstract
This research was carried out at a textile industry in Krian, Mojokerto and Nganjuk, East Java. Data is taken using questionnaires and interviews with production employees of the company. The number of samples used as respondents was 95 people from the total population of 1750 people. From the results of interviews and data collection via questionnaires and the results of data analysis, it shows that the working environment and social security variables have a significant effect on employees’ work productivity in textile industry.
The Cause And Effect Of Commercial Flight On-Time Performance (Case Study : Citilink)
Authors: Ratnasari Devi , Amanda Anggi Nurul , Darmawan Farhan , Warsito Tito , Amonalisa Siska 
Published: July 2020

Abstract
The needs of the air transportation is increasing day by day. In order to meet the demand, airline industries made full service, medium service and low cost carrier airline concepts. However, airline concepts might have some risk factors, notably the safety factor. Not only safety factor but The time factor is also a crucial factor in airline. Sometimes airline needs to do schedule changes due to some reasons. But, in fact the airline sometimes has to delay the schedule, and will affect the on-time performance (OTP). This research is aimed to find out the cause and effect of OTP in citilink airline used exploratory descriptive research with the cause and effect diagram method. The identify categories of causes used 5M, particularly regarding Manpower, Method, Mother Nature, Machine and Management. Researchers’ data collection methods are observation, interviews, and documentation, using three phases of data analysis, namely data collection, data classification, and drawing of conclusions.
Effect Of Maintenance System And Simulator Pilots On Aviation Safety In Airlines
Authors: Rahmawati S. D. , Maulida S. J. R. , Rafi S. , Ratnasari Devi 
Published: July 2020

Abstract
Safety and security are a priority in an aviation industry that is very mindful because it is crucial. In order to achieve that virtue, there are some things that must be noticed by the airline in supporting safety and security is the maintenance system which pays attention to the profanation of an aircraft to operate and A pilot simulator to prepare physical and mental pilot readiness in all natural situations and conditions while minimizing the risk of falling planes, two factors affecting the pilot’s performance in operating the aircraft Will reduce the accident rate significantly and can improve the pilot’s ability to deal with problems in the field through certain simulations related to these problems. This research aims to study flight readiness in terms of feasibility control by maintenance system and pilot readiness in the face of emergencies and decision making in crucial situation. This research uses a regression method whereby the data retrieval technique uses the questionnaire with the target of the pilot respondent of the airline Garuda Indonesia. The result of analysis Acquired linear equation multiple regression Y = 0.754+0.383X1+0.398X2, R is obtained at 0.518.
Preliminary investigation of Industry 4.0 readiness among small and medium aviation companies in Malaysia
Authors: Ghafar N H , Harun K , Lailawati M S , Rahman N A A 
Published: July 2020

Abstract
In recent years, the wave of Industry 4.0 is seen to encroach into the Malaysian aviation industry especially among major aviation companies. However, the Industry 4.0 readiness among small and medium aviation companies is virtually unknown. This study aimed to conduct a preliminary investigation on the Industry 4.0’s readiness level among small and medium aviation companies. Multiple case study has been conducted over 4 aviation companies (1 chartered airlines, and 3 maintenance, repair and overhaul (MRO) companies) operating in Malaysia. Data was collected using qualitative interview with managers of the respective companies and analysed using content analysis. Finding shows that the Industry 4.0 readiness status of small and medium aviation companies are still at the embryonic stage. The practical implication of this study contributes to the understanding of rising need for government agencies’ supports to assist the small and medium aviation companies particularly in overcoming the Industry 4.0 implementation challenges. The purposive sampling and the small number of samples limit the generalizability of the findings. Hence, full fledge empirical study is suggested to be conducted to facilitate the generalization to the whole aviation population.
Metrological characterization of MEMS accelerometers by LDV
Authors: D’Emilia Giulio , Gaspari Antonella , Mazzoleni Fabrizio , Natale Emanuela , Prato Andrea , Schiavi Alessandro 
Published: July 2020

Abstract
In this work two calibration methodologies, able to characterize the digital sensitivity of MEMS accelerometers, are presented and compared, to identify the contributions for the evaluation of the reproducibility in the low frequency range. The methodologies are different from the point of view of test bench, test procedure and data processing method. In particular, different vibration actuators are used, a linear slide and an electro-dynamic shaker, different sensors as a reference for the calibration, piezoelectric accelerometers and a Laser Doppler Vibrometer (LDV). A group of 5 accelerometers is tested for the purpose of developing the calibration techniques and evaluate a first reproducibility estimate. The experimental results provided by the two calibration procedures show significant differences. Some elements that could explain these differences have been identified, and will be further investigated in future work.
Measurement uncertainty estimation of gap and profile in the automotive sector
Authors: D’Emilia G , Gaspari A , Iavicoli C , Natale E 
Published: July 2020

Abstract
In this paper, a methodology is described aiming at assessing the variability causes, affecting the measurement instruments typically used in the automotive sector for the analysis of dimensional defects of coupled components, to check the conformity of the width of the gap between two adjacent parts and the profile, i.e. the alignment of the two surfaces. The inspection may be performed by means of different gap/flush tools, such as feeler gages, calipers and Laser scanner devices; depending on the choice, a different measurand has to be considered. The obtained measurements need to be consistent, because these devices are used indistinctly, depending on the severity of the control and on the typology of the control itself. The paper proposes a methodology to verify the metrological conformity of measurements provided by both traditional and laser-based instruments, so that it is possible to interpret them in an interchanging manner. A 3D geometric model is realized, used as a basis for the analysis of the most influencing uncertainty causes and measurement biases. The methodology will demonstrate to be able to identify and evaluate in a parametric way, the typical variability causes of the instruments considered. It will also highlight possible improvements in the integration of the obtained results.
Numerical performance assessment of a novel Darrieus-style VAWT with auxiliary straight blades
Authors: Arpino F. , Cortellessa G. , Massarotti N. , Mauro A. , Scungio M. 
Published: July 2020

Abstract
Domestic Vertical Axis Wind Turbines (VAWT) are able to operate also when the wind speed is low and can be installed in the open spaces of housing areas. The Darrieus turbine is the most promising since it is characterized by higher efficiency, even if for applications at higher wind speeds with respect to Savonius VAWTs. Several researchers try to optimize the aerodynamics of the Darrieus rotors, allowing wind turbines to start rotation even in the presence of low wind speeds. In this paper the authors propose a numerical investigation of the flow field around a 1:4 scaled model of a pair of blades installed on an innovative Darrieus-type VAWT. A Reynolds Averaged Navier-Stokes-based CFD model was validated on the basis of the wind tunnel data, and the scaled turbine performance was analysed by numerically evaluating the effect of different geometric configurations and rotation angles on the turbine torque coefficients. The results of the simulations confirmed the capabilities of the proposed configuration to give valuable performance even for low wind speeds.
Temporal Analysis of Radiocesium Concentration in Sewage Sludge after Fukushima Daichi Nuclear Power Plant Accident
Authors: Faturrohman M A , Pratama M A , Moersidik S S 
Published: July 2020

Abstract
Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident in April 2011 had released radioactive substances to the environment. Radiocesium transported from the urban area to the sewerage system by transfer wash-off mechanism. Eventually, radiocesium accumulated in the sludge produced by the wastewater treatment plant. This study was aimed to evaluate the possibility of using the time-series of Radiocesium concentrations in sewage sludge to quantify the wash off rate of the radionuclide on the surface of an urban area. This study used monitoring data from four WWTPs in Fukushima Prefecture and daily concentrations of Radiocesium in their sewer sludge over 8 years were collected. The results show time-dependent of Radiocesium concentration in sludge fitted with double exponential regression which means there are two rates: rapid rate (22 – 36 months) and slow rate (123 – 213 months). Values of the model parameters based on temporal analysis of radiocesium concentrations in sewage sludge are consistent with radiocesium wash off after the Chernobyl accident indicating that the decreasing rate of radiocesium concentrations in sewage sludge reflect the wash off rates on the surface of the corresponding urban area.
Analysis of Supply and Demand Situation of Low Carbon Energy in China Based on Grey System Neural Network
Authors: Xi Jing 
Published: July 2020

Abstract
At present, with the rapid development of the world economy, the demand for energy and resources is increasing day by day. Resource scarcity and environmental deterioration have become important issues facing the world. The energy development mode based on traditional fossil energy cannot support the rapid economic development of our country, which makes the energy transformation of our country imperative. In this paper, the grey GM (1, 1) model and artificial neural network are combined to modify the prediction results of GM (1, 1) model. In order to make GM(1, 1) model have higher prediction accuracy in medium and long-term prediction, partial data GM(1, 1) model groups are respectively established by using partial data sequences of original data, and the nonlinear mapping relationship between fitting values and original data is calculated by establishing this partial GM(1, 1) model groups by using BP neural network. The calculation results show that the prediction method is reliable and has high prediction accuracy.
Network Pharmacology Analysis of Anticonvulsant Effect of Xiao Chai Hu Tang
Authors: Kong Weikaixin , Huang Weiran , Huang Zhuo , Xie Zhengwei 
Published: July 2020

Abstract
Epilepsy is the second largest disease after headache in the neurology department of the hospital. Previous studies have shown that Xiao Chai Hu Tang (XCHT) has a certain therapeutic effect on epilepsy. We used the gene expression array data of epilepsy patients, and the relevant data of the Chinese medicine components in the TCMSP database and DrugBank database, combined with bioinformatics analysis methods, to construct herbs-compounds-targets (HCT) network and protein-protein interaction (PPI) core network of XCHT. The result suggests that Caveolin 1 (CAV1) may be a key target in the treatment of epilepsy, and β-carotene may have potential antiepileptic activity. In addition, the PPI core function network is enriched in the process of transcription factor regulation, and the related protein is located on the nuclear chromosome and closely related to the immune process, which provides a reference for other researchers.