bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence on Respectful Maternity Care For Adolescents: A Systematic Review Protocol
Authors: Habib Helen H , Mwaisaka Jefferson , Torpey Kwasi , Maya Ernest Tei , Ankomah Augustine 
Published: September 2020

Abstract
Background
Intrapartum mistreatment of women is a globally rising public health and human rights phenomenon. The issue reportedly has severe maternal and neonatal outcomes including mortality, and generally leads to a decreased satisfaction with maternity care. Intrapartum mistreatment, despite being ubiquitous, indicates higher incidence among adolescent parturients who are simultaneously at a higher risk of maternal morbidity and mortality. Studies have suggested that Respectful Maternity Care (RMC) interventions reduce intrapartum mistreatment and improve clinical outcomes for women and neonates in general. However, evidence on the effect of RMC on adolescents is unclear. Hence the specific aim of this study is to synthesise the available evidence relating to the provision of RMC for adolescents during childbirth.
Methods
The methodology of the proposed systematic review follows the procedural guideline depicted in the preferred reporting items for systematic review protocol. The review will include all observational and intervention studies conducted between January 1, 1990 and April 30, 2020. Electronic databases including MEDLINE, PubMed, ScienceDirect, Cochrane, CINAHL, PsycINFO, Scopus, Google Scholar, and Web of Science will be searched to retrieve available studies using the appropriate search strings. The search results will be appraised with Joanna Briggs Institute quality assessment tool. The selection of relevant studies, data extraction, and quality assessment of individual studies will be carried out by two independent authors.
Results
A systematic narrative synthesis of the resultant studies will be done, and the relevant themes extracted. Findings will also be summarised in tables.
Discussion
Respectful Maternity Care for adolescents holds great promise for improved maternal and neonatal care. However, there is a gap in knowledge on the interventions that work and the extent of their effectiveness. Findings from this study will be beneficial in improving Adolescents Sexual and Reproductive Health and Rights (ASRHR) and reducing maternal mortality, especially for adolescents.
Systematic review registration:
PROSPERO (Submitted 21 August 2020)
The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes
Authors: Rautenbach Petro Hannie , Nienaber-Rousseau Cornelie , Pieters Marlien 
Published: September 2020

Abstract
Background Alcohol consumption is associated with haemostasis and so may influence cardiovascular conditions. It is unknown whether the association of alcohol with total and γ’ fibrinogen concentrations, as well as clot structure, are modulated by fibrinogen and factor (F)XIII single nucleotide polymorphisms (SNPs). Methods Total fibrinogen, γ’ fibrinogen and clot properties of 2010 healthy black South Africans were measured in relation to alcohol intake as well as its markers – gamma-glutamyltransferase (GGT), percentage carbohydrate deficient transferrin (%CDT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Fourteen fibrinogen and two SNPs in the FXIII gene were genotyped to determine their influence. Results Alcohol intake and its markers correlated negatively with fibrinogen and clot lysis time (CLT) as well as with most of the clot properties. Percentage γ’ fibrinogen correlated positively with AST and negatively with alcohol intake. We then stratified for alcohol intake and found inverse associations between γ’ fibrinogen and both %CDT and GGT–CDT in consumers, but the positive association with AST remained only in abstainers. Alcohol intake and its markers modulated the influence of fibrinogen SNPs on total fibrinogen concentrations and the fibrinogen SNPs as well as an FXIII SNP on clot density (all p <0.004). Conclusion/s We show for the first time that some individuals harbour certain genotypes that, in combination with alcohol consumption, might predispose or protect them from haemostatic factors that might lead to the development of cardiovascular disease. Studies are needed to clarify the mechanisms related to the interplay between alcohol and gene variants observed here.
“Double hit” B-lymphoblastic lymphoma with concurrent IGH/BCL2 and 8q24/MYC translocations: a case report
Authors: He Lu , Li Zhiwen , Fan Xiangshan , Chen Jieyu , Wu Hongyan , Fu Yao 
Published: September 2020

Abstract
BackgroundB-lymphoblastic lymphomas (B-LBLs) with a documented “double-hit” (DH) (IGH/BCL2 and 8q24/MYC rearrangement) are rare and their clinical, cytogenetic and immunophenotypic features have not been well elucidated. Here we describe an unusual case of de novo DH B-LBL.Case presentationA 39-year-old man presented with abdominal distention at admission. Radiological findings revealed a retroperitoneal lump and multiple lymphadenopathy. Histologic examination of the abdominal mass showed a predominant population of neoplastic lymphoblasts with round nuclei, which focally formed single files surrounded by fibrotic septa. These cells have high nuclear to cytoplasmic ratio, fine chromatin, and no inconspicuous nucleoli. Necrosis, apoptotic bodies and mitotic figures were common. Prominent starry-sky appearance was not observed. The typical immunophenotype of malignant cells was positive for TdT, CD99, CD10, PAX-5, Bcl2 (70%), MYC (70%), and negative for CD34,Cyclin-D1, SOX11, CD56, and CD123. The proliferation index was high with Ki-67 of 80%. Fluorescence in situ hybridization (FISH) studies demonstrated 8q24/MYC rearrangement and IGH/BCL2 gene fusion. Subsequent bone marrow biopsy showed no involvement. Normal chromosome karyotype was observed. Finally, the diagnosis of “double-hit” B-LBL was clinically rendered. The patient showed an initial response to six cycles of hyper-CVAD chemotherapy (hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone) and was alive at the last follow-up (2020.4.10, six months after the diagnosis).ConclusionsFew guidelines regarding DH B-LBL are available in the literature or in the WHO scheme. The optimal clinical management of such patients has not been fully established attributed to the small number of reported cases. Multicenter data is warranted to better make clinical strategies on patients with DH B-LBL.
Better Health Related Quality of Life Reduced Elevated Lp(a) Levels in Man
Authors: Bao Jinlan , Wen ZhuZhi , Tang Ying , Sun Runlu , Huang Canxia , Wang JingFeng , Zhang Yuling 
Published: September 2020

Abstract
Background: Elevated Lipoprotein(a) (Lp(a)) is an independent risk factor for premature coronary heart disease (PCHD), but drug therapy rarely changes. Recently, health related quality of life (HRQOL) has been used to measure the prognosis of PCHD, but it is unclear whether HRQOL can improve Lp(a) levels. Aim: To explore whether HRQOL score in PCHD patients is closely related to increased Lp(a) level.Methods: The retrospective study included 448 male patients, 218 male patients with PCHD (49.63±3.72 years) and 230 male healthy controls, the two groups were matched in age. According to Lp(a) levels, they were divided into normal Lp(a) group (Lp(a)<30mg/dL) and elevated Lp(a) group (Lp(a)≥30mg/dL). All participants received HRQOL scores. HRQOL scores were assessed using the health Survey of 36 items (SF-36).Results: Elevated Lp(a) subgroup had more PCHD patients 150(65.5%) than normal Lp(a) subgroup 68(31.1%), P<0.001. In elevated Lp(a) subgroup and normal Lp(a) subgroup, the Lp(a) level of PCHD patients were significantly higher than health healthy controls, and HRQOL scores were significantly lower than healthy controls(P<0.001). HRQOL scores significantly reduced the risk of PCHD (P<0.001), while Lp(a) levels significantly increased the risk of PCHD (P<0.001). HRQOL scores in the whole Lp(a) group were negatively correlated with Lp(a) levels (r=-0.131, P=0.006), but not with the elevated Lp(a) and normal Lp(a) subgroups.Conclusion: Better HRQOL may be an important indicator to reduce the risk of high Lp(a) and PCHD in man.
Penetrating Atheromatous Ulcer as a Precursor of Aortic Dissection: A Case Report
Authors: Shah Priya , Polan Erik 
Published: September 2020

Abstract
Background: Acute aortic syndromes include a range of life-threatening conditions with the most familiar entity being aortic dissection. However, variants of aortic dissection also include intimal tear without hematoma, aortic intramural hematoma, and lastly penetrating aortic ulcer (PAU), which will be the focus of this case report. Most PAUs are located in the descending thoracic aorta (85-95%), but they can also occur in the ascending aorta or arch as in the current case.Case Presentation: We report a case of a 77 year old male who presented with chief complaint of intermittent right-handed weakness associated with no numbness or mental status changes. Patient was admitted for stroke workup with unrevealing findings on CT (computed tomography) for acute abnormalities or any hemodynamically significant stenosis on carotid ultrasound. CT angiogram of head/neck revealed a penetrating aortic ulcer of the lateral aspect of the mid to distal ascending aorta. Patient was then transferred for further evaluation to a center of higher level care for further management.Conclusions: Patient was evaluated for surgical repair of penetrating ascending aortic ulcer. Patient underwent serial imaging throughout hospital course which showed grossly similar findings to prior examination and thus no surgical intervention was needed at that time. Patient was recommended to have follow up CT scan in one month to monitor progression of aortic ulcer. Penetrating aortic ulcers are rarely located in the ascending aorta and are considered precursors of life-threatening aortic dissections.
P2X7R-mediated Autophagic Impairment Contributes to Central Sensitization in a chronic Migraine Model with Recurrent Nitroglycerin Stimulation in Mice
Authors: Jiang Li , Zhang Yixin , Jing Feng , Long Ting , Qin Guangcheng , Zhang Dunke , Chen Lixue , Zhou Jiying 
Published: September 2020

Abstract
Background: Central sensitization is an important pathophysiological mechanism of chronic migraine (CM). According to our previous studies, microglial activation and subsequent inflammation in the trigeminal nucleus caudalis (TNC) contribute to the central sensitization. The P2X7 receptor (P2X7R) is a purinergic receptor expressed in microglia and participates in central sensitization in chronic pain, but its role in CM is unclear. Numerous studies have shown that P2X7R regulates the level of autophagy and that autophagy affects the microglial activation and inflammation. Recently, autophagy has been shown to be involved in neuropathic pain, but there is no information about autophagy in CM. Therefore, the current study investigated the role of P2X7R in CM and its underlying mechanism, focusing on autophagy regulation.Methods: The CM model was established by repeated intraperitoneal injection of nitroglycerin (NTG) in mice. A Von Frey filament and radiant heat were used to assess the mechanical and thermal hypersensitivity. Western blotting and immunofluorescence assays were performed to detect the expression of P2X7R, autophagy-related proteins, and the cellular localization of P2X7R. To determine the role of P2X7R and autophagy in CM, we detected the effects of the autophagy inducer, rapamycin (RAPA) and P2X7R antagonist, Brilliant Blue G (BBG), on pain behavior and the expression of calcitonin gene-related peptide (CGRP) and c-fos. In addition, the effect of RAPA and BBG on microglial activation and subsequent inflammation were investigated.Results: The expression of P2X7R was increased and was mainly colocalized with microglia in the TNC following recurrent NTG administration. The autophagic flux was blocked in CM, which was characterized by up-regulated LC3-II, and accumulated autophagy substrate protein, p62. RAPA significantly improved the basal rather than acute hyperalgesia. BBG alleviated both basal and acute hyperalgesia. BBG activated the level of autophagic flux. RAPA and BBG inhibited the activation of microglia, limited the inflammatory response, and reduced the expression of CGRP and c-fos. Conclusions: Our results demonstrate the dysfunction of the autophagic process in CM. Activated autophagy may have a preventive effect on migraine chronification. P2X7R contributes to central sensitization through mediating autophagy regulation and might become a potential target for CM.
Exciton–phonon coupling strength in single-layer MoSe2 at room temperature
Authors: Li Donghai , Trovatello Chiara , Conte Stefano Dal , Nuß Matthias , Soavi Giancarlo , Wang Gang , Ferrari Andrea , Cerullo Giulio , Brixner Tobias 
Published: September 2020

Abstract
Single-layer transition metal dichalcogenides (1L-TMDs) are at the center of an ever increasing research effort both in terms of fundamental physics and applications. Exciton–phonon coupling (EXPC) plays a key role in determining the photonic and (opto)electronic properties of 1L-TMDs. However, the EXPC strength has not been measured at room temperature. Here, we develop two-dimensional (2D) micro-spectroscopy to determine EXPC of 1L-MoSe2. We detect beating signals as a function of waiting time T, induced by the coupling between the A exciton and the A'1 optical phonon. Analysis of 2D beating maps provides the EXPC with the help of simulations. The Huang–Rhys factor of ~1 is larger than in most other inorganic semiconductor nanostructures. Our technique offers a unique tool to measure EXPC also in other 1L-TMDs and heterogeneous semiconducting systems with a spatial resolution ~260 nm, and will provide design-relevant parameters for the development of novel optoelectronic devices.
Sulpiride-Induced Dystonia in Tourette Syndrome; A Stroke Mimicking Presentation
Authors: Abdelnaby Ramy , Abosrea Mona Ali , Rudek Markus A. , Elsayed Mohamed 
Published: September 2020

Abstract
We report a case of sulpiride induced dystonia, which was misleading to identify because of the acute onset during exercise mimicking stroke in a Tourette syndrome patient. After excluding artery dissection through MR-Angiography, Biperiden was infused, which lead to the immediate disappearance of the dystonic symptoms.
2D Visual Analysis of SARS-CoV-2
Authors: Zheng Jeffrey , Qiao Mu , Wu Ruoxue 
Published: September 2020

Abstract
COVID-19 is outbreaking in worldwide. It caused millions of infections, killing hundreds of thousands of people and making all countries loss immeasurable trade. For finding the secret of SARS-CoV-2, researchers need to analyze various variation information such as multiple coronaviruses in different times over distinct countries. In this paper, the metagenetic analysis system MAS is used to analyze SARS-CoV-2 genomes collected from different countries as input datasets, and special genomic indices are provided to be a global characteristic quantity based on the A1 and C1 modules of the MAS for visualizations. In this method, one RNA sequence is split into M segments and counting the number of genetic probability measures for 16 combinations of four genomic symbols. After statistical probability processes, each probability distribution can be transferred into an entropy quantity on both 2D and 1D histograms to show these results for all collected genomes. Under this approach, a pair of combinatorial entropies determine a 2D genomic index map to generate a heatmap for more massive clusters of genomes with similarity contents to provide basic quantitative in variants to organize further collected genomes as a construction of a phylogenetic tree. Further explorations are required.
Effects of Various Conditions Related to Circadian Rhythm Disturbances on Plasma and Erythrocyte Lipids in Rats: A Peroxisomal Perspective
Authors: Otlu Hüsniye Gül , Uğur Yılmaz , Yıldız Azibe , Erdoğan Selim , Yoloğlu Saim , Vardı Nigar , Güldür Tayfun 
Published: September 2020

Abstract
Background: It was aimed to investigate effects of various conditions known to cause circadian rhythm disturbances (i.e. calorie restriction, time-restricted feeding, constant light exposure) on various peroxisomal parameters and to compare those effects with that of fenofibrate, a PPARα agonist, in rats. Methods: Plasmalogens and some fatty acids in erythrocyte lysates were analyzed by GC. Peroxisomal metabolites including very long chain fatty acids as well as phytanic and pristanic acids in plasma were measured by GC-MS. Results: Unlike calorie restricted feeding, fenofibrate treatment yielded lower level of plasma phytanic acid concentration implying higher peroxisomal α-oxidation rate. However both calorie restriction and fenofibrate treatment exhibited lower plasmalogen, DHA and arachidonic acid contents of erythrocyte lysates. Conclusion: Shared effects of conditions associated with circadian rhythm disturbances and peroxisomal induction by fenofibrate on erythrocyte membrane lipids might indicate a link between them.
Index Analysis of Osteonecrosis and Related Causes
Authors: Liu Tingting , Cao Yuju , Wu Huiqiang , An Feimeng , Han Changxu , Wang Tiantian , Sun Menghu , Tian Ye , Wang Kunzheng , Wang Jianzhong 
Published: September 2020

Abstract
Background: The pathogenesis of non-traumatic osteonecrosis of the femoral head (ONFH ) is related to the interruption of blood supply caused by lipid metabolism and hypercoagulability. The purpose of this study was to explore the relationship between clinical biochemical parameters and non-traumatic ONFH. Methods: The basic information and biochemical indexes of 1292 patients with non- traumatic ONFH and 1880 healthy controls were collected. SPSS software (version 22.0) was used to process and analyze the data. T-test was used for quantitative analysis. Chi-square test was used for categorical variables.p< 0.05 were the index with statistical significance. Results: In the population sample, TC (p= 0.00004), LDL (p= 0.014) and PLT (p= 0.000005) levels were statistically significant between the two groups.In men, levels of TC (p = 0.004), LDL (p= 0.011), and PLT (p= 0.00005) were statistically significant between the two groups.In women, TC (p= 0.001) and PLT (p= 0.048) levels were statistically significant between the two groups.There were differences in TC (p= 0.00001) and PLT (p= 0.031) levels between the case group and the control group in samples aged less than 45 years.There were differences in LDL (p= 0.00002) and PLT (p= 0.022) levels between the two groups in samples older than 45 years.Compared with the control group, patients with alcohol-induced ONFH had HDL (p = 0.002).LDL (p= 0.00002);The level of PLT (p= 0.0001) was significantly different.HDL (p = 0.005) was found in alcohol-induced ONFH patients younger than 45 years of age.The PLT level (p=0.045) was different from that of the control group.There was a difference in LDL (p= 0.000003) levels between control and alcohol-induced ONFH patients older than 45 years.The older the onset age, the TC in vivo;HDL;LDL;ApoA1;ApoB;The lower the PLT level.With the prolongation of the onset time, the PLT level in the patient's body is decreasing continuously.Conclusion: The changes of biochemical indexes are closely related to the occurrence of non-traumatic ONFH. Our research can provide a new direction for the prevention of ONFH.
Sleep Disturbance is Associated With Cognitive Impairment: a Community Population-based Cross-sectional Study
Authors: Gao Fan , Wei Shan , Dang Liangjun , Gao Yao , Gao Ling , Shang Suhang , Chen Chen , Huo Kang , Wang Jingyi , Wang Jin , Qu Qiumin 
Published: September 2020

Abstract
Background: Sleep is an important physiological process and conducive to the elimination of brain metabolites and the recovery of brain function. However, the relationship between sleep disturbance and cognitive impairment is not fully been determined.Methods: This was a community population-based cross-sectional study. A total of 1,461 participants from a village in the suburbs of Xi’an, China were enrolled from January 3 to March 26, 2017. Sleep quality was evaluated using the Pittsburgh sleep quality index (PSQI), and sleep disturbance was defined as a PSQI score >5. Mini-mental state examination (MMSE) was used to assess cognitive function and cognitive impairment was defined as the MMSE score less than cutoff values and meets the diagnostic criteria. Univariate and multivariate analyses were used to analyze the relationships between sleep disturbance and cognitive impairment.Results: Among 1,461 subjects, 87(5.95%) had cognitive impairment, and 842 (57.63%) had sleep disturbance. In bivariate analysis, cognitive impairment was associated with insomnia (ρ=1.000, P＜0.001), age (ρ=0.172, P＜0.001) and educational level (ρ=-0.160, P＜0.001). In the binary logistic regression, cognitive impairment was positively associated with the sleep disturbance (OR=1.779, 95%CI=1.055-3.001, P=0.031). In the internal constitution of PSQI, cognitive impairment was positively associated with the sleep interference (OR=1.678; 95%CI=1.029-2.736, P=0.038), and negatively associated with the habitual sleep efficiency (OR=0.115, 95%CI=0.043-0.306, P<0.001). However, people sleep more than 8 hours a day are more likely to suffer from cognitive impairment (OR=3.174, 95%CI=1.570-6.417, P=0.001). Conclusions: Sleep disturbance is associated with cognitive impairment. However, the causal relationships between sleep disturbances and cognitive impairment are not clear. It needs to be further studied.
A New Method for Error Modeling in the Kinematic Calibration of Redundantly Actuated Parallel Kinematic Machine
Authors: He Lei-Ying , Wang Zhen-Dong , Li Qin-Chuan , Chai Xin-Xue 
Published: September 2020

Abstract
This paper presents a new method for error modeling and studies the kinematic calibration of redundantly actuated parallel kinematic machines (RA-PKM). First, a n-DOF RA-PKM is split into several n-DOF non-redundantly actuated sub-mechanisms by removing actuators in limbs in an ergodic manner without changing the DOF. The error model of the sub-mechanisms is established by differentiating the forward kinematics. Then, the complete error model of the RA-PKM is obtained by a weighted summation of errors for all sub-mechanisms. Finally, a kinematic calibration experiments are performed on a 3-DOF RA-PKM to verify the method of error modeling. The positioning and orientation error of the moving platform is replaced by the positioning error of the tool center point, which was reduced considerably from 3.427 mm to 0.177 mm through kinematic calibration. The experimental results demonstrate the improvement of the kinematic accuracy after kinematic calibration using the proposed error modeling method.