bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Psychometric Evaluation of the Fathers' Fear of Childbirth Scale: A Mixed Method Study
Authors: Ghaffari Seyedeh Fatemeh , Nia Hamid Sharif , Elyasi Forouzan , Mohammadpoorsaravimozafar Zohre , Shahhosseini Zohreh 
Published: December 2020

Abstract
Background: Fear of childbirth is reported in 13% of fathers, and it may have adverse consequences for the health of fathers as well as their families. Due to the lack of a valid and reliable questionnaire to measure fathers' fear of childbirth, this study was conducted to develop the Fathers' Fear of Childbirth Scale and evaluate its psychometric properties. Methods: This mixed method study was conducted in two phases. In the qualitative phase (or item generation), semi-structured interviews were conducted with 20 expectant fathers, and a literature review was performed to generate the Fathers' Fear of Childbirth Scale items pool. In the quantitative phase (or psychometric evaluation), reliability as well as face, content, and construct validity of this scale were evaluated. To establish construct validity, exploratory and confirmatory factor analyses were performed. Reliability was evaluated through internal consistency and composite reliability measures. Results: The primary version of Fathers' Fear of Childbirth Scale contained 32 items, which were reduced to 17 items while establishing construct validity. Exploratory factor analysis extracted two factors, namely fear of childbirth process (12 items) and fear of hospital (5 items). These factors explained 50.82% of the total variance. Goodness of fit indices within the confirmatory factor analysis was acceptable. Internal consistency and composite reliability indices of all the factors were greater than 0.70. Conclusion: The Fathers' Fear of Childbirth Scale has a suitable validity and reliability for assessing fear of childbirth in fathers. It is a simple report instrument that can be easily implemented by health care professionals.
A high-resolution brain proteome map uncovers the Inter-hemispheric laterality &amp; Inter-regional protein expression changes
Authors: Srivast Sanjeeva , Biswas Deeptarup , Shenoy Sanjyot , Chetanya Chetanya , Athithyan Arunachalam , Lachén-Montes Mercedes , Ghosh Susmita , Ausín Karina , Zelaya María , Fernández-Irigoyen Joaquín , Manna Akash , Roy Sudesh , Barpanda Abhilash , Ball Graham , Santamaría Enrique , Talukdar Arunansu 
Published: December 2020

Abstract
The human brain has always been a black box full of mysteries. Here we present one of the most comprehensive proteomics investigation of the brain, focusing on inter-hemispheric differences. An extensive mass spectrometry-based analysis of 19 brain regions from both left and right hemispheres measured more than 3300 proteins and 38700 peptides. This high-resolution data provides a comprehensive coverage of experimentally measured (non-hypothetical) proteins across various regions to characterize inter-hemispheric differences. We also tried to understand the brain proteins in terms of synapse analysis. The study has attempted to investigate the expression of neuroanatomical allied region and brain disorder protein markers in 19 region and sub-region of brain. Furthermore, we have developed the most comprehensive Brain Proteome Database, based on our, and publicly available curated data representing more than 9000 proteins (with isoforms) and around 90000 peptides at www.brainprot.org, which can aid in understanding the human brain’s complexity.
Upper temperature limits of orogenic gold deposit formation: Constraints from TiO2 polymorphs in the Dongyuan Au deposit, Jiangnan Orogen, China
Authors: Wu Shenghua , Mao Jingwen , Yu Hong , Tan Daorong , Geng Xinxia 
Published: December 2020

Abstract
Gold (Au) deposits have formed in orogenic belts throughout Earth’s history. However, the upper temperature limits of orogenic Au vein formation are difficult to constrain because measurements made on fluid inclusions focus on intermediate to late-stage minerals (e.g., quartz and calcite) or are based on P-T estimates for the metamorphic mineral assemblages of the host rocks. We conducted a study of TiO2 polymorphs that are among the earliest minerals that grew in Au-bearing veins of the Dongyuan deposit, Jiangnan orogenic Au belt, South China. Based on Raman analyzes, we identified TiO2 polymorphs of anatase (with Raman peaks at 396, 515, and 638 cm−1), rutile (with Raman peaks at 235, 447, and 613 cm−1), and anatase–rutile intergrowths. Transmission electron microscope (TEM) confirmed the polymorphs identifying the [111] zone axis of anatase, [110] zone axis of rutile, and [111] and [111] zone axes of rutile–anatase intergrowths. The TiO2 polymorphs in the Dongyuan Au veins constrain a temperature range for early mineral precipitation in the veins of 450–550 °C. The results show that ore-forming fluids for this orogenic Au deposit emplaced in the shallow crust originated from deeper and hotter crustal levels (e.g., high-grade metamorphic rocks in the middle to lower crust).
Wczesne wspomaganie rozwoju dzieci niewidomych i edukacja tyflopedagogiczna ich rodzin na przykładzie projektu "Międzynarodowa szkoła matek"
Authors: Kuczyńska-Kwapisz Jadwiga 
Published: December 2020

Opisywany projekt ma dwa powiązane z sobą cele: wczesne wspomaganie rozwoju dzieci niewidomych oraz kształcenie tyflopedagogiczne członków ich rodzin. Pierwsza edycja projektu odbyła się w 2008 roku i od tego czasu, każdego roku w lipcu, w nim uczestniczę. W artykule kolejno przedstawiam następujące zagadnienia: opis osób pracujących w projekcie, warunki, w których się on odbywa, uczestników, ramowy program, warsztaty z rodzicami oraz krótką charakterystykę wybranych rodzin, a także opis zajęć z zakresu orientacji przestrzennej i lokomocji, które z nimi prowadziłam. W krajach uczestniczących w projekcie jest olbrzymia potrzeba społeczna organizowania pomocy edukacyjnej rodzinom z dziećmi niewidomymi. Bez wsparcia profesjonalistów rodzicom trudno jest zadbać o prawidłowy rozwój małego niewidomego dziecka. Dobrą praktyką w opisywanej „Międzynarodowej Szkole Matek” jest angażowanie bardzo zróżnicowanych profesjonalistów pod względem specjalności, narodowości, wieku, doświadczeń, możliwości wzrokowych, światopoglądu i in. Program zajęć realizowanych w projekcie jest elastycznie dostosowany do indywidualnych potrzeb każdej rodziny, zainteresowań i możliwości dziecka.
Anti-malarial Drugs are Not Created Equal for SARS-CoV-2 Treatment: A Computational Analysis Evidence
Authors: Ronsisvalle Simone , Panarello Federica , Di Mauro Rosaria , Bernardini Renato , Volti Giovanni Li , Cantarella Giuseppina 
Published: December 2020

Background:
The evolution of the pandemic has burdened the national healthcare systems worldwide
and at present, there is no preferred antiviral treatment for COVID-19. Recently, the SARS-Cov-2 protease
structure was released that may be exploited in in-silico studies in order to conduct molecular docking analysis.

Methods:
In particular, we compared the binding of twoantimalarial drugs, already in use, (i.e. chloroquine and
hydroxychloroquine), which showed some potential clinical effects on COVID-19 patients, using ritonavir, lopinavir
and darunavir as positive control tree antiviral recognized compounds.

Results:
Our results showed that hydroxychloroquine but not chloroquine exhibited a significant binding activity
to the main protease similar to that possessed by protease inhibitors tested for other viral infections.

Conclusion:
Our data suggest that hydroxychloroquine may exert additional direct antiviral activity compared
to chloroquine. In the absence of clinical studies comparing the efficacy of these two compounds, hydroxychloroquine
may offer additional effects and may be considered as the first choice.
Yb/Chitosan Catalyzed Synthesis of Highly Substituted Piperidine Derivatives for Potential Nuclease Activity and DNA Binding Study
Authors: Laskar Khairujjaman , Farhan Mohd , Ahmad Aamir 
Published: December 2020

Background:
Herein, a new chitosan-supported ytterbium nano-catalyst has been prepared and used
in a mild, efficient, and expeditious method for the synthesis of substituted piperidine derivatives via threecomponent
condensation of substituted anilines, formaldehyde and different cyclic/acyclic active methylene
compounds at room temperature.

Methods:
The catalyst was characterized by FTIR, XRD, SEM, EDX, TEM, ICP-AES and the stability of the
catalyst was evaluated by TG analysis. The synthesized compound 3,3,11,11-Tetramethyl-15-(phenyl)-15-
azadispiro[5.1.5.3]hexadecane-1,5,9,13-tetrone (3a) was explored for pBR322 DNA cleavage activity and genotoxicity.
Further, the interaction of 3a with CT-DNA was investigated through UV-vis, fluorescence and viscosity.

Results:
The preparation of Yb/chitosan nano-catalyst was verified and the catalyst was found effective towards
substituted piperidine formations with the catalyst reusability. Compound 3a was successfully tested for DNA
cleavage activity. In addition, fluorescence results revealed that compound 3a interacted with DNA with a binding
affinity of 4.84 x 104 M-1.

Conclusion:
Our findings suggest that compounds bearing spiro-piperidine scaffold, synthesized using reusable
nano-catalyst, could be effective biological agents.
Phospholipid Analogues as Chemotherapeutic Agents Against Trypanosomatids
Authors: Chazapi Evanthia , Magoulas George E. , Prousis Kyriakos C. , Calogeropoulou Theodora 
Published: December 2020

Background:
Neglected tropical diseases (NTDs) represent a serious problem in a number of countries
around the world and especially in Africa and South America, affecting mostly the poor population which
has limited access to the healthcare system. The drugs currently used for the treatment of NTDs are dated many
decades ago and consequently, present in some cases very low efficacy, high toxicity and development of drug
resistance. In the search for more efficient chemotherapeutic agents for NTDs, a large number of different compound
classes have been synthesized and tested. Among them, ether phospholipids, with their prominent member
miltefosine, are considered one of the most promising.

Objective:
This review summarizes the literature concerning the development of antiparasitic phospholipid derivatives,
describing the efforts towards more efficient and less toxic analogues while providing an overview of
the mechanism of action of this compound class against trypanosomatids.

Conclusion:
Phospholipid analogues are already known for their antiprotozoal activity. Several studies have
been conducted in order to synthesize novel derivatives with the aim to improve current treatments such as
miltefosine, with promising results. Photolabeling and fluorescent alkyl phospholipid analogues have contributed
to the clarification of the mode of action of this drug family.
Vitiligo: An Updated Narrative Review
Authors: Leung Alexander K.C. , Lam Joseph M. , Leong Kin Fon , Hon Kam Lun 
Published: December 2020

Background:
Vitiligo is a relatively common acquired pigmentation disorder that can
cause significant psychological stress and stigmatism.

Objective:
This article aims to familiarize physicians with the clinical manifestations, evaluation,
diagnosis, and management of vitiligo.

Methods:
A Pubmed search was conducted in Clinical Queries using the key term “vitiligo”. The
search included meta-analyses, randomized controlled trials, clinical trials, observational studies,
and reviews. The search was restricted to English language. The information retrieved from the
above search was used in the compilation of the present article.

Results:
Approximately one quarter of patients with vitiligo have the onset before 10 years of age.
Genetic, immunological, neurogenic and environmental factors may have a role to play in the
pathogenesis. Vitiligo typically presents as acquired depigmented, well-demarcated macules/patches
that appear milk- or chalk-white in color. Lesions tend to increase in number and enlarge centrifugally
in size with time. Sites of predilection include the face, followed by the neck, lower
limbs, trunk, and upper limbs. The clinical course is generally unpredictable. In children with fair
skin, no active treatment is usually necessary other than the use of sunscreens and camouflage cosmetics.
If treatment is preferred for cosmesis, topical corticosteroids, topical calcineurin inhibitors,
and narrowband ultraviolet B phototherapy are the mainstays of treatment.

Conclusion:
The therapeutic effect of all the treatment modalities varies considerably from individual
to individual. As such, treatment must be individualized. In general, the best treatment response
is seen in younger patients, recent disease onset, darker skin types, and head and neck lesions. Topical
corticosteroids and calcineurin inhibitors are the treatment choice for those with localized disease.
Topical calcineurin inhibitors are generally preferred for lesions on genitalia, intertriginous areas,
face, and neck. Narrowband ultraviolet B phototherapy should be considered in patients who
have widespread vitiligo or those with localized vitiligo associated with a significant impact on the
quality of life who do not respond to treatment with topical corticosteroids and calcineurin inhibitors.
Anti-acne Treatment using Nanotechnology based on Novel Drug Delivery System and Patents on Acne Formulations: A Review
Authors: Singh Vandana , Redhu Rakesh , Verma Ravinder , Mittal Vineet , Kaushik Deepak 
Published: December 2020

Background:
Acne is one of the most infectious diseases related to human skin. This disease
of acne is of higher prevalence in adults. The main causative organism involved in the acne vulgaris
is Propionibacterium acne, which leads to sebum production and follicular hyperkeratinization.

Methods:
The scientific data shows inflammatory mediators of genetic factors, stress, physiological
factor, androgens and hormonal changes; all these factors play a major part in the pathophysiology of
acne. Several drugs are currently available for the treatment of Acne like bactericidal, antibiotic and
several others which are directly or indirectly involved in the eradication of acne.

Results:
Nanocarrier systems including liposomes, niosomes, microsponges, nano-emulsion and
micro-emulsion, microspheres and solid lipid nanoparticles have emerged as a successful treatment
for acne. In this article, the authors have laid special emphasis on these nanocarriers and the study of
various patents based on novel technologies in this field. The entrapment of the anti-acne drug molecule
into a particular nanocarrier system has been shown to enhance patient compliance and reduction
in side-effects.

Conclusion:
The present review article provides an overview of the mechanism, advantages, drawbacks
and various patents associated with the nanocarrier systems involved in acne treatment. Some
state of the art patented and novel technologies such as stem cell secretion technology, sol-gel technology
incorporating microcapsules and ultrasound delivery of nanoparticles for acne treatment, are
also briefly discussed. The patent study on these nanocarriers was done through the worldwide database
of the United States patent office, European patent office and several other official patent information
websites.
Recovery of a 91-year-old COVID-19 Patient with Medical and Psychological Support
Authors: Zhang Dong , Liu Chunrong , Li Li 
Published: December 2020

Background::
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is designated as a global pandemic. Elderly men with underlying
medical conditions are more susceptible to SARS-CoV-2 infection and usually develop severe/
critical illness, therefore more attention we should be paid to them.

Objective::
Describe methods that may help old patients with COVID-19 recover.

Methods::
A case of a 91-year-old male COVID-19 patient in Haihe Hospital, Tianjin, China, has
been reported here who survived after receiving supportive medical treatment and psychological
assistance.

Results::
In addition to medical interventions, psychological support may be needed to better treat
COVID-19 patients, including the elderly.

Conclusion::
Special care should be provided for elderly COVID-19 patients. Mutual understanding
and support between patients and health-care workers are essential during this pandemic.
Strategi Panti Sosial Marsudi Putra (PSMP) Antasena Magelang dalam Pelayan dan Rehabilitasi Anak Berhadapan Hukum (ABH)
Authors: Maghfiroh Shinta Astrini , Pratiwi Poerwanti Hadi 
Published: December 2020

Penelitian ini membahas tentang kondisi dan latar belakang Anak Berhadapan Hukum (ABH) yang berada di PSMP Antasena, strategi yang dilaksanakan oleh PSMP Antasena dalam melakukan pelayanan dan rehabilitasi terhadap ABH, serta manfaatnya Penelitian ini menggunakan metode penelitian kualitatif deskriptif. Pengumpulan data dalam penelitian dilakukan dengan observasi, wawancara, dan dokumentasi. Teknik validasi yang dilakukan dengan teknik triangulasi data. Teknik analisis data dalam penelitian ini menggunakan analisis model Miles dan Huberman yaitu pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa kondisi latar belakang ABH sehingga melakukan tindakan penyimpangan dipengaruhi oleh faktor ketidakharmonisan keluarga, pergaulan teman sebaya, kemiskinan, serta kemajuan teknologi yang semakin bebas. Strategi PSMP Antasena dilakukan melalui beberapa program dan kegiatan yaitu; case conference, bimbingan agama, konseling dan terapi psikososial, penegakan hukum, bimbingan etika sosial, pemberian keteladanan, keterbukaan komunikasi, penekanan kata-kata, konsultasi keluarga, dan bimbingan lanjut. Manfaat yang diberikan kepada ABH dari adanya pelayanan dan rehabilitasi adalah membentuk pola kebiasaan yang baik, membentuk kesadaran dan kemampuan diri, membentuk akhlak yang ramah dan santun, melatih ketrampilan, serta pada saat setelah keluar dari panti telah siap untuk kembali bersosialisasi dengan keluarga dan masyarakat.
eHealth Delivery of Educational Content Using Selected Visual Methods to Improve Health Literacy on Lifestyle-Related Diseases: Literature Review
Authors: Aida Azusa , Svensson Thomas , Svensson Akiko Kishi , Chung Ung-Il , Yamauchi Toshimasa 
Published: December 2020

Background
Lifestyle-related diseases, such as stroke, heart disease, and diabetes, are examples of noncommunicable diseases. Noncommunicable diseases are now the leading cause of death in the world, and their major causes are lifestyle related. The number of eHealth interventions is increasing, which is expected to improve individuals’ health literacy on lifestyle-related diseases.

Objective
This literature review aims to identify existing literature published in the past decade on eHealth interventions aimed at improving health literacy on lifestyle-related diseases among the general population using selected visual methods, such as educational videos, films, and movies.

Methods
A systematic literature search of the PubMed database was conducted in April 2019 for papers written in English and published from April 2, 2009, through April 2, 2019. A total of 538 papers were identified and screened in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram. Finally, 23 papers were included in this review.

Results
The 23 papers were characterized according to study characteristics (author and year of publication, study design and region where the study was conducted, study objective, service platform, target disease and participant age, research period, outcomes, and research method); the playback time of the educational videos, films, and movies; and the evaluation of the study’s impacts on health literacy. A total of 7 studies compared results using statistical methods. Of these, 5 studies reported significant positive effects of the intervention on health literacy and health-related measures (eg, physical activity, body weight). Although most of the studies included educational content aimed at improving health literacy, only 7 studies measured health literacy. In addition, only 5 studies assessed literacy using health literacy measurement tools.

Conclusions
This review found that the provision of educational content was satisfactory in most eHealth studies using selected visual methods, such as videos, films, and movies. These findings suggest that eHealth interventions influence people’s health behaviors and that the need for this intervention is expected to increase. Despite the need to develop eHealth interventions, standardized measurement tools to evaluate health literacy are lacking. Further research is required to clarify acceptable health literacy measurements.
Good Glycemic Outcomes Following Bariatric Surgery Among Patients With Type 2 Diabetes, Obesity, and Low-Titer GAD Antibodies
Authors: Kaur Ruveena , Kim David , Cutfield Richard , Booth Michael , Plank Lindsay , Murphy Rinki 
Published: December 2020

OBJECTIVE
To evaluate diabetes remission after bariatric surgery by presence of GAD antibody among those with obesity and type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
Screening GAD was performed in 221 patients with T2D and obesity referred for bariatric surgery. Nine of 16 patients with GAD and 112 of 205 without GAD proceeded with surgery. Diabetes remission and weight loss were compared by GAD presence.

RESULTS
The group with GAD had levels 16–91 IU/mL. Those with and without GAD were similar with regard to age, BMI, diabetes duration, proportion treated with insulin, HbA1c, and C-peptide (1,354 ± 548 vs. 1,358 ± 487 pmol/L). At 1 and 5 years postoperatively, the two groups achieved similar BMI reduction and diabetes remission (67% vs. 73%, P = 0.71, and 56% vs. 57%, P = 1.0).

CONCLUSIONS
Low-titer GAD in patients with T2D and retained C-peptide should not be a deterrent for bariatric surgery when the principal aim is diabetes remission.