bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seizures in autoimmune encephalitis: Kindling the fire
Authors: Wesselingh Robb , Butzkueven Helmut , Buzzard Katherine , Tarlinton David , O'Brien Terence J. , Monif Mastura 
Published: May 2020

AbstractEpilepsy is a common neurological disorder that increases the risk of morbidity and mortality. Autoimmune epilepsy is a subset of epilepsy that occurs in the setting of autoimmunity, such as in autoimmune encephalitis (AIE). AIE is an autoimmune disorder characterized by immune‐mediated neuroinflammation resulting in a variety of neurological symptoms, including psychiatric disturbance, cognitive dysfunction, and seizures. Seizures in AIE are thought to be a result of antibodies directed against neuronal cell‐surface proteins involved in synaptic transmission. The role of blood‐brain barrier dysfunction, myeloid cell infiltration, and the initiation of proinflammatory cascades in epileptogenesis has been shown to be important in animal models and human patients with epilepsy. Epileptogenesis in AIE is likely to arise from the synergistic effect of both innately driven neuroinflammation and antibody‐induced hyperexcitability. Together, these processes produce persistent drug‐resistant seizures that contribute to the morbidity seen in AIE. Understanding the proinflammatory pathways involved in this process may improve diagnostics and provide alternative treatment targets in AIE.
Stereotactic laser anterior corpus callosotomy for Lennox‐Gastaut syndrome
Authors: Tao James X. , Satzer David , Issa Naoum P. , Collins John , Wu Shasha , Rose Sandra , Henry Julia , Santos de Lima Fabiane , Nordli Douglas , Warnke Peter C. 
Published: May 2020

AbstractObjectiveCorpus callosotomy is an effective palliative treatment for drug‐resistant Lennox‐Gastaut syndrome (LGS). Laser interstitial thermal therapy has been increasingly used in the treatment of epilepsy. Here, we assess the safety and effectiveness of minimally invasive stereotactic laser anterior corpus callosotomy (SLACC) for drop attacks in LGS.MethodsWe reviewed sequential cases of patients with medically intractable LGS who underwent SLACC using a two‐cannula technique between November 2014 and July 2019. Pre‐ and postoperative magnetic resonance imaging was used to measure the anteroposterior length of callosal ablation (contrast‐enhancing lesion) and estimated disconnection (gap in tract projections on diffusion tensor imaging). Patients were followed longitudinally to assess clinical outcomes.ResultsTen patients were included in this study. The median age was 33 (range = 11‐52) years, median duration of epilepsy was 26 (range = 10‐49) years, and median duration of postoperative follow‐up was 19 (range = 6‐40) months. In the anteroposterior direction, 53 ± 7% (mean ± SD) of the corpus callosum was ablated and 62 ± 19% of the corpus callosum was estimated to be disconnected. Six (60%) of 10 patients achieved >80% seizure reduction, two (20%) of whom became seizure‐free. Eight (80%) patients had >80% reduction in drop attacks, five (50%) of whom became free of drop attacks. Three patients subsequently underwent laser posterior callosotomy with further improvement in drop attacks and/or overall seizure frequency. One patient had an asymptomatic intracerebral hemorrhage along the cannula tract. One patient developed significant aggression after becoming seizure‐free.SignificanceSeizure outcomes following SLACC were comparable to previously reported outcomes of open callosotomy, with reasonable safety profile. SLACC appears to be an effective alternative to open anterior corpus callosotomy with minimal postoperative discomfort and a short recovery period.
On the identification and analysis of citation pattern irregularities among journals
Authors: Chakraborty Joyita , Pradhan Dinesh K. , Nandi Subrata 
Published: May 2020

AbstractRecent studies report that few journals are adopting unethical citation practices to inflate Impact Factor (IF) artificially. “Clarivate Analytics” has started to blacklist such journals since 2006. As reported in the literature, evaluation of journals individually, to detect anomalies from vast and dynamically changing citation network is not efficient. The primary purpose of this work is to define a diverse feature set that can identify such cases of extreme outliers and reason them. The sample size is narrowed down using an unsupervised clustering algorithm in the absence of a labeled training dataset. Next, time‐series IF data is analyzed to detect point outliers. Furthermore, microscopic features are identified to reason them. Results reflected from the F‐value after ANOVA analysis reveals that geometrical patterns (self‐loop, pairwise and group mutual‐citation) among journals, an abrupt increase in the paper count of donor and corresponding IF inflation of recipient are some of the essential features. Microscopic features include social factor (calculation of revised IF after removing directed self or mutual‐citation), impact of the field of study, impact of publication house and author factor that includes author self and mutual‐citation. The significance of this work is to ensure that the quality of a journal is withheld without compromising research integrity by controlling or auditing individual features periodically.
Mapping potentials adjacent to the cavo‐tricuspid isthmus ablation line during incremental pacing: A feasible and highly accurate maneuver to confirm complete CTI conduction block
Authors: Jiménez‐López Jesus , Vallès Ermengol , Martí‐Almor Julio , González‐Matos Carlos , Bas Deva , Benito Begoña , Alcalde Oscar , Cabrera Sandra , Altaba Carmen , Bazan Victor 
Published: May 2020

AbstractBackgroundThe diagnostic accuracy of incremental atrial pacing (IP) to determine complete cavo‐tricuspid isthmus (CTI) block during typical atrial flutter (AFL) ablation is limited by both an extensive/nonlinear ablation and/or the presence of intra‐atrial conduction delay elsewhere in the right atrium. We examined the diagnostic performance of an IP variant based on the assessment of the atrial potentials adjacent to the ablation line which aims at overcoming both limitations.MethodsFrom a prospective population of 108 consecutive patients, 15 were excluded due to observation of inconclusive CTI ablation potentials precluding for a straight comparison between the IP maneuver and its variant. In the remaining 93, IP was performed from the low lateral right atrium and the coronary sinus ostium, with the ablation catheter positioned both at the CTI line and adjacent (<5 mm) to its septal and lateral aspect. The IP variant consisted of measuring the interval between the two atrial electrograms situated on the same side of the ablation line, opposite to the pacing site, a ≤10 ms increase indicating complete CTI block.ResultsThe IP maneuver and its variant were consistent with complete CTI block in 82/93 (88%) and 87/93 (93%) patients, respectively. Four patients had AFL recurrence during follow‐up: 2/4 and 4/4 had been adequately classified as incomplete block by the IP maneuver and its variant, respectively. Twenty‐three patients (24%) had significant intra‐atrial conduction delay elsewhere in the right atrium. The IP maneuver and its variant were suggestive of an incomplete CTI block in 11/23 and 4/23 in this setting (P = .028), with the later best predicting subsequent AFL relapses (2/12 vs 2/4, P = .01).ConclusionsThe IP variant, which was designed to overcome the limitations of the conventional IP maneuver, accurately distinguishes complete from incomplete CTI block and helps to predict AFL recurrences after ablation.
How EU Juridification shapes Constitutional Social Rights
Authors: Bruzelius Cecilia 
Published: May 2020

AbstractThis article demonstrates how EU member states' distinct constitutional traditions shape the impact of EU juridification on national welfare states and social rights. These traditions come with different ‘constitutional social rights norms’ – that is, distinct distributions of obligation and power to protect social rights between judicial and political actors. The article argues that norms common to the political constitutional tradition are less compatible with the EU's juridified notion of rights than those distinguishing legal constitutionalism. To develop this argument, the article takes an in‐depth look at Germany and Sweden, which represent the two constitutional traditions. This reveals how the Swedish constitutional understanding of social rights as politically defined collective rights has shifted towards a more juridified notion of rights, as EU law effectively makes social entitlements defined in national legislation more justiciable. The already significantly juridified understanding of social rights in Germany, in contrast, comes closer to that of the EU.
Certolizumab for the treatment of psoriasis and psoriatic arthritis: a real‐world multicentre Italian study
Authors: Dattola A. , Balato A. , Megna M. , Gisondi P. , Girolomoni G. , De Simone C. , Caldarola G. , Cama E. , Piaserico S. , Fargnoli M.C. , Fidanza R. , Parodi A. , Burlando M. , Offidani A. , Diotallevi F. , Potenza C. , Conti A. , Chiricozzi A. , Campione E. , Bianchi L. 
Published: May 2020

AbstractBackgroundCertolizumab, a pegylated tumour necrosis factor‐α inhibitor, reduced disease activity in randomized trials of patients with psoriasis and psoriatic arthritis. Real‐life data are missing.ObjectiveTo confirm the effectiveness and safety of certolizumab in patients with psoriasis and psoriatic arthritis in routine clinical practice.MethodsIn this retrospective study involving 11 Italian sites, patients with psoriasis and psoriatic arthritis received subcutaneous certolizumab (400 mg loading dose at 0, 2 and 4 weeks, followed by 200 mg every 2 weeks) for up to 52 weeks. Primary outcomes included mean change from baseline in Psoriasis Area and Severity Index (PASI) and modified Nail Psoriasis Severity Index (mNAPSI) scores, and the proportion of patients achieving a 75%, 90% or 100% reduction in PASI score. Other endpoints included Disease Activity Score computed on 44 joints correlated with the erythrocyte sedimentation rate during the first hour (DAS44‐ESR), Tender Joint Count (TJC), Swollen Joint Count (SJC), pain [visual analogue scale (VAS) score], inflammatory markers and quality of life (QOL).ResultsIn the study were enrolled 153 patients (mean age: 55 years). Certolizumab reduced the mean PASI score from baseline by 4.45, 6.30 and 7.58 at weeks 12, 24 and 52, respectively (P < 0.001 for all). At weeks 24 and 52, 69.6% and 83.3% of patients had a PASI score ≤3. DAS44‐ESR, TJC, SJC and mNAPSI scores, and pain VAS were also all significantly improved from baseline at each time point. C‐reactive protein levels decreased during treatment, being significant at week 24. On multivariate analysis, psoriasis duration, baseline PASI, mNAPSI and pain VAS scores were found to be predictive of the improvement in PASI score at week 12.ConclusionCertolizumab displayed also in the real‐life encouraging results in both psoriasis and psoriatic arthritis patients.
Population expansion of the invasive Pomacentridae Chromis limbata (Valenciennes, 1833) in southern Brazilian coast: long‐term monitoring, fundamental niche availability and new records
Authors: Anderson Antônio B. , da Silva Jodir Pereira , Sorvilo Raquel , Francini Carlo Leopoldo B. , Floeter Sergio R. , Barreiros João P. 
Published: May 2020

AbstractHuman‐mediated species invasions are recognized as a leading cause of global biotic homogenization and extinction. Studies on colonization events since early stages, establishment of new populations and range extension are scarce because of their rarity, difficult detection and monitoring. Chromis limbata is a reef‐associated and non‐migratory marine fish from the family Pomacentridae found in depths ranging between 3 and 45 m. The original distribution of the species encompassed exclusively the eastern Atlantic, including the Azores, Madeira and the Canary Islands. It is also commonly reported from West Africa between Senegal and Pointe Noire, Congo. In 2008, vagrant individuals of C. limbata were recorded off the east coast of Santa Catarina Island, South Brazil (27° 41′ 44″ S, 48° 27′ 53″ W). This study evaluated the increasing densities of C. limbata populations in Santa Catarina State shoreline. Two recent expansions, northwards to São Paulo State and southwards to Rio Grande do Sul State, are discussed, and a niche model of maximum entropy (MaxEnt) was performed to evaluate suitable C. limbata habitats. Brazilian populations are established and significantly increasing in most sites where the species has been detected. The distributional boundaries predicted by the model are clearly wider than their known range of occurrence, evidencing environmental suitability in both hemispheres from areas where the species still does not occur. Ecological processes such as competition, predation and specially habitat selectivity may regulate their populations and overall distribution range. A long‐term monitoring programme and population genetics studies are necessary for a better understanding of this invasion and its consequences to natural communities.
Comparison of the efficiency of two different proton pump inhibitor formula in treatment of patients with atypical gastroesophageal reflux disease: a prospective randomized study
Authors: Lin Xi‐Hsuan , Luo Jiing‐Chyuan , Ting Po‐Hsiang , Chang Tien‐En , Huang Yi‐Hsiang , Hou Ming‐Chih , Lee Fa‐Yauh 
Published: May 2020

AbstractBackground and AimThe prospective, open‐label, randomized study aims to compare the efficacy of lansoprazole, a fast orally disintegrating proton pump inhibitor (PPI), and dexlansoprazole, a dual delayed release PPI, in patients with atypical symptoms of gastroesophageal reflux disease (GERD).MethodsPatients with atypical GERD symptoms with a total reflux symptom index score > 10 were eligible for enrollment. From February 2018 to December 2019, 232 subjects were randomly assigned (1:1 ratio) to receive oral lansoprazole, Takepron OD 30 mg, once daily before breakfast or oral dexlansoprazole, Dexilant 60 mg, once daily before breakfast for 8 weeks. The primary end‐point is to compare the symptoms response rate after an 8‐week PPI therapy between the two groups.ResultsThere were 232 study subjects enrolling in this study. After the 8‐week PPI therapy, dexlansoprazole‐treated group had a significantly higher response rate than lansoprazole‐treated group in cough (76.5% vs 38.0%) and globus (69.7% vs 30.8%) (P all < 0.05 by intention‐to‐treat). Multivariate logistic regression analysis showed that the use of dexlansoprazole, presence of dyslipidemia, and typical GERD symptoms (acid reflux and heartburn) were predictors for symptom response for cough; the use of dexlansoprazole and presence of erosive esophagitis were predictors for symptom response for globus (P all < 0.05). No predictor for therapy response to hoarseness was noted.ConclusionsThere is a higher response rate for cough and globus symptoms in patients with atypical GERD after the 8‐week PPI therapy with dexlansoprazole rather than lansoprazole.
Professionals' Perspectives on Partnering with Families of Individuals with ID
Authors: John Aesha 
Published: May 2020

AbstractBackgroundSince individuals with intellectual disability (ID) and their parents rely on a wide variety of support and services from helping professionals such as social workers, teachers, and therapists, family‐professional partnership is an important area of research. Although past research sheds light on parental views on partnership, relatively few studies have focused on professionals' perspectives.Specific AimsThe aim of this study was to capture the perspectives of ID professionals on partnering with families of individuals with ID.MethodForty‐three ID professionals participated in a focus group that included open‐ended questions on characteristics of their most and least effective partnerships with families, and supportive and challenging factors in forming partnerships with parents.FindingsThematic analyses of the focus group responses helped uncover five themes: (1) clear, honest, and respectful communication between professionals and families, (2) the quality of relationship between the professional and the client's family, (3) professionals' and parents' knowledge and experience in the ID field, (4) degree to which a family is involved, and (5) realistic expectations.DiscussionThese findings can inform both the training of future professionals and parent education initiatives, and in turn, positively impact the quality of parent‐professional partnerships.
The clinical and economical impact of postoperative ileus in patients undergoing colorectal surgery
Authors: Peters Emmeline G. , Pattamatta Madhuri , Smeets Boudewijn J. J. , Brinkman Daan J. , Evers Silvia M. A. A. , de Jonge Wouter J. , Hiligsmann Mickaël , Luyer Misha D. P. 
Published: May 2020

AbstractBackgroundColorectal surgery is associated with postoperative ileus (POI). Despite its widespread manifestation, the influence of POI on recovery, quality of life (QoL), and costs is largely unknown. The aim of this study was to assess whether the inflammatory processes found in experimental studies are also evident in patients undergoing colorectal surgery. In addition, the impact of POI on short and long‐term QoL and costs was investigated.MethodsWe analyzed the outcomes of the SANICS‐II trial, including prospective evaluation of inflammatory parameters in blood samples, costs from a societal perspective and QoL, using validated questionnaires. Outcomes were compared between patients with and without POI, and in particular patients with POI as unique complication.Key ResultsA total of 265 patients (POI, n = 66 vs non‐POI, n = 199) were included and 38/66 had POI as only complication. CRP levels were significantly increased on postoperative day (POD) 1, 2, 3, and 4 in patients with POI. Furthermore, plasma levels of cytokines IL‐6, Il‐8 and IL‐10 were significantly increased the first 2 days after resection. Patients with POI had a higher overall complication rate and a reduced QoL 3 months postoperatively, even in the only POI group. Moreover, mean societal cost per patient with POI was 38%‐47% higher at 3 months postoperatively.Conclusions & InferencesSupporting findings from experimental studies, inflammatory parameters were increased in patients with only POI and comparable with all patients with POI. These results demonstrate the impact and large contribution of POI in postoperative inflammation, costs and QoL in patients undergoing colorectal surgery.
Cannabidiol on 5‐FU‐induced oral mucositis in mice
Authors: Cuba Letícia de Freitas , Salum Fernanda Gonçalves , Guimarães Francisco Silveira , Cherubini Karen , Borghetti Ruchielli Loureiro , de Figueiredo Maria Antonia Zancanaro 
Published: May 2020

AbstractPurposeThe aim of this study was to evaluate the clinical, histological, hematological, and oxidative stress effects of cannabidiol (CBD) in mice with induced oral mucositis.MethodsWe used 90 mice of the CF‐1 strain in which oral mucositis was induced using a protocol with 5‐fluorouracil (5‐FU) chemotherapy. The animals were divided randomly into 10 study groups. Three groups were treated with different doses of CBD (3, 10, and 30 mg/kg), while 2 were control groups (positive control: 5‐FU + mechanical trauma + placebo; and negative control: mechanical trauma + placebo), and 2 experimental times were studied (4 and 7 days). All treatments were by intraperitoneal administration.ResultsIn the clinical evaluation, the groups treated with CBD showed less severity of oral lesions compared with the positive control at both experimental times. The intensity of the inflammatory response was also lower in the groups treated with this drug, but there was no statistically significant difference when compared with the positive control. With regard to erythrocyte, leukocyte, and platelet counts and anti‐oxidant enzyme activity, the groups treated with CBD showed better results, but only some of these variables showed statistically significant differences.ConclusionsCBD seems to exert an anti‐inflammatory and anti‐oxidant activity favoring a faster resolution of oral mucositis in this animal model.
Phosphorus addition increased carbon partitioning to autotrophic respiration but not to biomass production in an experiment with Zea mays
Authors: Ven Arne , Verlinden Melanie S. , Fransen Erik , Olsson Pål Axel , Verbruggen Erik , Wallander Håkan , Vicca Sara 
Published: May 2020

AbstractPlant carbon (C) partitioning—the relative use of photosynthates for biomass production, respiration, and other plant functions—is a key but poorly understood ecosystem process. In an experiment with Zea mays, with or without arbuscular mycorrhizal fungi (AMF), we investigated the effect of phosphorus (P) fertilization and AMF on plant C partitioning. Based on earlier studies, we expected C partitioning to biomass production (i.e., biomass production efficiency; BPE) to increase with increasing P addition due to reduced C partitioning to AMF. However, although plant growth was clearly stimulated by P addition, BPE did not increase. Instead, C partitioning to autotrophic respiration increased. These results contrasted with our expectations and with a previous experiment in the same set‐up where P addition increased BPE while no effect on autotropic respiration was found. The comparison of both experiments suggests a key role for AMF in explaining these contrasts. Whereas in the previous experiment substantial C partitioning to AMF reduced BPE under low P, in the current experiment, C partitioning to AMF was too low to directly influence BPE. Our results illustrate the complex influence of nutrient availability and mycorrhizal symbiosis on plant C partitioning.
Mutation of MEDIATOR 18 and chromate trigger twinning of the primary root meristem in Arabidopsis
Authors: Ruiz‐Aguilar Bricia , Raya‐González Javier , López‐Bucio Jesús Salvador , Reyes de la Cruz Homero , Herrera‐Estrella Luis , Ruiz‐Herrera León Francisco , Martínez‐Trujillo Miguel , López‐Bucio José 
Published: May 2020

AbstractPlants adapt to soil injury and biotic stress via cell regeneration. In Arabidopsis, root tip damage by genotoxic agents, antibiotics, UV light and cutting induces a program that recovers the missing tissues through activation of stem cells and involves ethylene response factor 115 (ERF115), which triggers cell replenishment. Here, we show that mutation of the gene encoding an MED18 subunit of the transcriptional MEDIATOR complex and chromate [Cr(VI)], an environmental pollutant, synergistically trigger a developmental program that enables the splitting of the meristem in vivo to produce twin roots. Expression of the quiescent centre gene marker WOX5, auxin‐inducible DR5:GFP reporter and the ERF115 factor traced the changes in cell identity during the conversion of single primary root meristems into twin roots and were induced in an MED18 and chromate‐dependent manner during the root twinning events, which also required auxin redistribution and signalling mediated by IAA14/SOLITARY ROOT (SLR1). Splitting of the root meristem allowed dichotomous root branching in Arabidopsis, a poorly understood process in which stem cells may act to enable whole organ regeneration.