bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyomavirus‐driven Merkel cell carcinoma: Prospects for therapeutic vaccine development
Authors: Tabachnick‐Cherny Shira , Pulliam Thomas , Church Candice , Koelle David M. , Nghiem Paul 
Published: March 2020

AbstractGreat strides have been made in cancer immunotherapy including the breakthrough successes of anti‐PD‐(L)1 checkpoint inhibitors. In Merkel cell carcinoma (MCC), a rare and aggressive skin cancer, PD‐(L)1 blockade is highly effective. Yet, ~50% of patients either do not respond to therapy or develop PD‐(L)1 refractory disease and, thus, do not experience long‐term benefit. For these patients, additional or combination therapies are needed to augment immune responses that target and eliminate cancer cells. Therapeutic vaccines targeting tumor‐associated antigens, mutated self‐antigens, or immunogenic viral oncoproteins are currently being developed to augment T‐cell responses. Approximately 80% of MCC cases in the United States are driven by the ongoing expression of viral T‐antigen (T‐Ag) oncoproteins from genomically integrated Merkel cell polyomavirus (MCPyV). Since T‐Ag elicits specific B‐ and T‐cell immune responses in most persons with virus‐positive MCC (VP‐MCC), and ongoing T‐Ag expression is required to drive VP‐MCC cell proliferation, therapeutic vaccination with T‐Ag is a rational potential component of immunotherapy. Failure of the endogenous T‐cell response to clear VP‐MCC (allowing clinically evident tumors to arise) implies that therapeutic vaccination will need to be potent anśd synergize with other mechanisms to enhance T‐cell activity against tumor cells. Here, we review the relevant underlying biology of VP‐MCC, potentially applicable therapeutic vaccine platforms, and antigen delivery formats. We also describe early successes in the field of therapeutic cancer vaccines and address several clinical scenarios in which VP‐MCC patients could potentially benefit from a therapeutic vaccine.
More around Cattaneo equation to describe heat transfer processes
Authors: Spigler Renato 
Published: March 2020

We revisit Cattaneo's derivation of the equation describing heat transfer and bearing his name, finding a more elaborated model equation, that we will compare with the time‐lagged model. This equation does not comply with the second law of thermodynamics, as well as Cattaneo equation. The latter, however, is known to have provided meaningful results in certain experiments conducted in some liquids and solids at very low temperature. These experiments also match the results given by a nonlinear model proposed by A. Morro and T. Ruggeri in 1988, which instead does meet the laws of thermodynamics. A comparison is made with such a model too.
Preventing polyspermy in mammalian eggs—Contributions of the membrane block and other mechanisms
Authors: Evans Janice P. 
Published: March 2020

AbstractThe egg's blocks to polyspermy (fertilization of an egg by more than one sperm) were originally identified in marine and aquatic species with external fertilization, but polyspermy matters in mammalian reproduction too. Embryonic triploidy is a noteworthy event associated with pregnancy complications and loss. Polyspermy is a major cause of triploidy with up to 80% of triploid conceptuses being the result of dispermic fertilization. The mammalian female reproductive tract regulates the number of sperm that reach the site of fertilization, but mammals also utilize egg‐based blocks to polyspermy. The egg‐based blocks occur on the mammalian egg coat (the zona pellucida) and the egg plasma membrane, with apparent variation between different mammalian species regarding the extent to which one or both are used. The zona pellucida block to polyspermy has some similarities to the slow block in water‐dwelling species, but the mammalian membrane block to polyspermy differs substantially from the fast electrical block that has been characterized in marine and aquatic species. This review discusses what is known about the incidence of polyspermy in mammals and about the mammalian membrane block to polyspermy, as well as notes some lesser‐characterized potential mechanisms contributing to polyspermy prevention in mammals.
Flame retardant and mechanical properties of expandable graphite/polyurethane foam composites containing iron phosphonate dopamine‐coated cellulose
Authors: Yun Gyeong Won , Lee Joo Hyung , Kim Seong Hun 
Published: March 2020

AbstractAdditive‐type flame retardants used in polyurethane foams (PUFs) have low compatibility with the matrix and have a large particle size which reduces the mechanical strength. To overcome this, cellulose‐based additive‐type flame retardants were prepared. Microcrystalline cellulose (MCC) was grinded to a suitable size to be applying as a reinforcement for urethane foam. The ground MCC was coated with the mussel‐derived adhesive protein, dopamine, and formed the iron phosphonate coordination network on the surface. It was confirmed that the modification proceeded well by structural analysis by Fourier‐transform infrared spectrometer and morphology analysis by scanning electron microscope. In the synthesis of PUF, expandable graphite (EG) was added to obtain high flame retardancy. The PUF mixed with 3 wt% of ground MCC‐based flame retardant and 12 wt% of EG (GCF3) was found to have an excellent limiting oxygen index (LOI) of 25.3%, while the LOI of pure PUF was 19.3%. In particular, the compressive strength of GCF3 was remarkably enhanced (21 wt%) compared with the PUF containing 15 wt% of EG. This study produced a new additive‐type flame retardant to improve mechanical strength. This provides a simple and comprehensive solution for PUF applications requiring high flame retardancy and mechanical strength.
Expansile cribriform Gleason pattern 4 has histopathologic and molecular features of aggressiveness and greater risk of biochemical failure compared to glomerulation Gleason pattern 4
Authors: Greenland Nancy Y. , Cowan Janet E. , Zhang Li , Carroll Peter R. , Chan Emily , Stohr Bradley A. , Simko Jeffry P. 
Published: March 2020

AbstractBackgroundMolecular testing of prostate cancer biopsies with Gleason pattern 4 suggests the expansile cribriform pattern is more aggressive than the glomerulation pattern. These two extreme patterns have not been compared at prostatectomy. We hypothesized that at prostatectomy the expansile cribriform pattern would be associated with histopathologic and molecular features of aggressiveness and with greater risk of biochemical recurrence (BCR) than the glomerulation pattern.MethodsIn a retrospective cohort study, radical prostatectomy reports with expansile cribriform pattern or glomerulation pattern were analyzed for percentage of total pattern 4, extraprostatic extension (EPE), positive lymph nodes, seminal vesicle invasion (SVI), and intraductal carcinoma (IDC). Cases with pattern 5 or with both expansile cribriform and glomerulations patterns present were excluded. The electronic medical record was reviewed for BCR‐free survival and for Decipher test results.ResultsOf 1020 radical prostatectomies from July 2015 to July 2018, 110 (11%) had either expansile cribriform or glomerulation pattern present. The expansile cribriform group was associated with more histopathologic features of aggressiveness, with higher average total percentage pattern 4 (43.7 vs 27.0, P = .002), a trend of greater extensive EPE (32.7% vs 17.2%, P = .06), a trend toward statistical significance of higher rate of SVI (11.5% vs 3.4%, P = .1), greater positive lymph nodes (9.6% vs 0%, P = .02), and a higher percentage of cases with or suspicious for IDC (23.1% vs 8.6%, P = .04). The risk of BCR was 4.4 (1.3‐15.4) fold greater for the expansile cribriform group vs the glomerulations group (P = .02). For the 38 patients who underwent Decipher testing, the expansile cribriform group had a high‐risk assay category mean score whereas the glomerulations group had an average risk assay category mean score (0.61 vs 0.47, P = .02).ConclusionsIn a comparison of prostatectomy cases with expansile cribriform pattern to those with glomerulation pattern, the expansile cribriform pattern was associated with more histopathologic features of aggressiveness, greater risk of biochemical failure, and higher scores with a molecular classifier (Decipher) test. These findings underscore the importance of reporting the types of pattern 4 and supports the argument that men with expansile cribriform likely require more aggressive management.
Closed‐form expressions for predicting moment redistribution in reinforced concrete beams with application to conventional concrete and ultrahigh performance fiber reinforced concrete
Authors: Sturm Alexander B. , Visintin Phillip , Oehlers Deric J. 
Published: March 2020

AbstractThe redistribution of moment within a statically indeterminate reinforced concrete beam at the ultimate limit state occurs through variations in the flexural rigidities and through the formation of hinges. The phenomena of moment redistribution (MR) is used to increase the efficiency of reinforced concrete design by allowing moments to be transferred away from critical cross sections thereby resulting in lower design moments. To allow for this effect in design, two main approaches are adopted. The first is to perform an elastic analysis and then to adjust the resulting distribution of moment using a codified MR factor. The second is to apply a plastic analysis allowing for the formation of hinges, and to calculate the rotational requirements at the hinges from first principles. This paper uses fundamental plastic analyses to derive closed‐form expressions for the hinge rotational requirements for full MR (that required to achieve the theoretical maximum applied load within the beam based on the moment capacity of sections within the beam). These closed‐form solutions are then used to quantify the maximum load on a beam when the rotational capacities at a hinge are less than the rotational requirements for full MR (partial MR). Closed‐form solutions are then used to derive MR factors which do not require semimechanical calibration.
Teaching the Three E's of Sustainability Through Service‐Learning in a Professional Program
Authors: Reames Tony G. , Blackmar Jeannette M. , Pierce John C. 
Published: March 2020

AbstractUsing seven established course design principles for effective service‐learning, this chapter discusses the lessons learned in teaching the three E's of sustainability: environmental; economic; and (social) equity, in a professional program at an American Midwestern public university.
Resilient Learners, Learning Resilience: Contemplative Practice in the Sustainability Classroom
Authors: Goralnik Lissy , Marcus Sonia 
Published: March 2020

AbstractThrough literature review, anecdote, and empirical case study, this chapter explores the role of contemplative practice—yoga, meditation, reflection, breathwork—in the sustainability classroom as a way to increase both learner resilience and learner capacity to engage the challenging content of socio‐ecological resilience.
The geometric Standard Model Effective Field Theory
Authors: Helset Andreas , Martin Adam , Trott Michael 
Published: March 2020

Abstract
We develop the geometric formulation of the Standard Model Effective Field Theory (SMEFT). Using this approach we derive all-orders results in the $$ \sqrt{2\left\langle {H}^{\dagger }H\right\rangle }/\Lambda $$

2

H
†

H

/
Λ
expansion relevant for studies of Electroweak Precision and Higgs data.
New limits on neutrino non-unitary mixings based on prescribed singular values
Authors: Flieger Wojciech , Gluza Janusz , Porwit Kamil 
Published: March 2020

Abstract
Singular values are used to construct physically admissible 3-dimensional mixing matrices characterized as contractions. Depending on the number of singular values strictly less than one, the space of the 3-dimensional mixing matrices can be split into four disjoint subsets, which accordingly corresponds to the minimal number of additional, non-standard neutrinos. We show in numerical analysis that taking into account present experimental precision and fits to different neutrino mass splitting schemes, it is not possible to distinguish, on the level of 3-dimensional mixing matrices, between two and three extra neutrino states. It means that in 3+2 and 3+3 neutrino mixing scenarios, using the so-called α parametrization, ranges of non-unitary mixings are the same. However, on the level of a complete unitary 3+1 neutrino mixing matrix, using the dilation procedure and the Cosine-Sine decomposition, we were able to shrink bounds for the “light-heavy” mixing matrix elements. For instance, in the so-called seesaw mass scheme, a new upper limit on |Ue4| is about two times stringent than before and equals 0.021. For all considered mass schemes the lowest bounds are also obtained for all mixings, i.e. |Ue4|, |Uμ4|, |Uτ4|. New results obtained in this work are based on analysis of neutrino mixing matrices obtained from the global fits at the 95% CL.
Human host defense peptide LL-37 facilitates double-stranded RNA pro-inflammatory signaling through up-regulation of TLR3 expression in vascular smooth muscle cells
Authors: Dahl Sara , Cerps Samuel , Rippe Catarina , Swärd Karl , Uller Lena , Svensson Daniel , Nilsson Bengt-Olof 
Published: March 2020

Abstract
Objective
The importance of human host defense peptide LL-37 in vascular innate immunity is not understood. Here, we assess the impact of LL-37 on double-stranded RNA (dsRNA) signaling in human vascular smooth muscle cells.

Materials and methods
Cellular import of LL-37 and synthetic dsRNA (poly I:C) were investigated by immunocytochemistry and fluorescence imaging. Transcript and protein expression were determined by qPCR, ELISA and Western blot. Knockdown of TLR3 was performed by siRNA.

Results
LL-37 was rapidly internalized, suggesting that it has intracellular actions. Co-stimulation with poly I:C and LL-37 enhanced pro-inflammatory IL-6 and MCP-1 transcripts several fold compared to treatment with poly I:C or LL-37 alone. Poly I:C increased IL-6 and MCP-1 protein production, and this effect was potentiated by LL-37. LL-37-induced stimulation of poly I:C signaling was not associated with enhanced import of poly I:C. Treatment with poly I:C and LL-37 in combination increased expression of dsRNA receptor TLR3 compared to stimulation with poly I:C or LL-37 alone. In TLR3 knockdown cells, treatment with poly I:C and LL-37 in combination had no effect on IL-6 and MCP-1 expression, showing loss of function.

Conclusions
LL-37 potentiates dsRNA-induced cytokine production through up-regulation of TLR3 expression representing a novel pro-inflammatory mechanism.
Shoulder injuries in polytraumatized patients: an analysis of the TraumaRegister DGU®
Authors: Briese Thorben , Theisen Christina , Schliemann Benedikt , Raschke Michael J. , Lefering Rolf , Weimann Andre 
Published: March 2020

Abstract
Background
The aim of the present study was to analyze the prevalence, epidemiology and relevance of shoulder injuries in polytraumatized patients in a large national trauma database.
We hypothesize a high prevalence of shoulder injuries in traffic accidents and a high prevalence of concomitant injuries of the thorax leading to an aggravated clinical course and higher Injury Severity Score (ISS). Furthermore, we hypothesize an increased rate of surgical treatment with the severity of the injury.

Materials and methods
The retrospective analysis is based on the database (2002–2013) of the TraumaRegister DGU® and includes statistical data from 608 hospitals. The severity of injuries and trauma were scaled using the Abbreviated Injury Scale (AIS), and the Injury Severity Score (ISS), respectively. Patients with an ISS ≥ 16 were included in the study, and injuries were subdivided according to their anatomical involvement and analyzed with respect to the trauma mechanism and the resulting injuries.

Results
In this study, 54,076 cases of patients with an ISS ≥ 16 were analyzed. Shoulder injuries occurred in 15,115 patients (27.9%). Of these, 68.5% were caused by traffic accidents, especially in motorbike, bicycle, and pedestrian accidents. We found more shoulder injuries in blunt trauma mechanisms. Moreover, patients with shoulder injuries spent on average 1.7 more days on the intensive care unit (ICU), or intermediate care unit (IMCU), according to the severity of the injury, and had longer overall hospital stays (26.2 vs. 24.1 days) than patients without shoulder injuries. The overall ISS was increased in patients with shoulder injuries, whereas an increase of mortality could not be identified. Concomitant thoracic injuries occurred significantly more often in patients with shoulder injuries (82.9% vs. 69.6%). Injuries of the abdomen, pelvis, and lower extremity showed no correlation with shoulder injuries, whereas head and spine injuries showed a significant correlation.

Conclusion
Shoulder injuries are very common in polytraumatized patients. Together with their distinctive concomitant injuries, they have an aggravating impact on the clinical progress. Our data confirm the correlation with thoracic injuries. Furthermore, we identified an increased risk of shoulder injuries in motorbike, bicycle, and pedestrian accidents. An increase in mortality could not be identified.
Models for autoregressive processes of bounded counts: How different are they?
Authors: Kim Hee-Young , Weiß Christian H. , Möller Tobias A. 
Published: March 2020

AbstractWe focus on purely autoregressive (AR)-type models defined on the bounded range $$\{0,1,\ldots , n\}$$

{
0
,
1
,
…
,
n
}

with a fixed upper limit $$n \in \mathbb {N}$$

n
∈
N

. These include the binomial AR model, binomial AR conditional heteroscedasticity (ARCH) model, binomial-variation AR model with their linear conditional mean, nonlinear max-binomial AR model, and binomial logit-ARCH model. We consider the key problem of identifying which of these AR-type models is the true data-generating process. Despite the volume of the literature on model selection, little is known about this procedure in the context of nonnested and nonlinear time series models for counts. We consider the most popular approaches used for model identification, Akaike’s information criterion and the Bayesian information criterion, and compare them using extensive Monte Carlo simulations. Furthermore, we investigate the properties of the fitted models (both the correct and wrong models) obtained using maximum likelihood estimation. A real-data example demonstrates our findings.
Cold and heavy: grasping the temperature–weight illusion
Authors: Kuhtz-Buschbeck Johann P. , Hagenkamp Johanna 
Published: March 2020

AbstractThe apparent heaviness of weights placed on the skin depends on their temperature. We studied the effects of such a temperature–weight illusion (TWI) on perception and action in 21 healthy volunteers. Cold (18 °C), thermal-neutral (32 °C, skin temperature) and warm (41 °C) test objects were placed onto the palm of the non-dominant hand. Their veridical mass was 350 g (light) or 700 g (heavy). Perception of heaviness was assessed with two psychophysical experiments (magnitude estimation, cross modal matching). Cold heavy objects felt about 20% heavier than thermal-neutral objects of the same mass, shape and material. In a subsequent grip-lift experiment, the test objects were grasped with a precision grip of the dominant hand and lifted off the palm of the non-dominant hand. The grip and lift forces exerted by the fingertips were recorded. The temperature of the objects had significant effects (ANOVA, p < 0.05) on the peak grip and lift forces and on the peak grip force rate (i.e., the initial force incline). The peak grip force was about 10% higher when cold heavy objects were grasped and lifted, compared to lifts of otherwise identical thermal-neutral objects. The TWI was less pronounced when light objects or warm objects were handled. In conclusion, cooling of an object increases its apparent heaviness (perception) and influences scaling of the fingertip forces during grasping and lifting (action).
Spectroscopic studies on the molecular interactions of curcumin and piperine
Authors: Traxler Florian , Schinnerl Johann , Brecker Lothar 
Published: March 2020

Abstract
The diarylheptanoid curcumin is the yellow coloring agent accumulated in the rhizome of the common spice turmeric (Curcuma longa L.). It has gathered a lot of pharmaceutical interest over the last decades due to some positive effects on human health. However, the use of curcumin as a drug is prevented by its low bioavailability and solubility in water. Interestingly, piperine, the pungent constituent of household pepper (Piper nigrum L.) is able to increase the bioavailability of curcumin up to 20-fold without any known adverse effects. The mechanism responsible for this piperine-based increase of curcumin bioavailability is, however, not fully understood. In a recent publication, a quantum chemical study suggested the formation of a molecular complex between curcumin and piperine being responsible for this effect. The present work now revealed that indeed a 1:1 complex formation can be observed in NMR titration experiments and by mass spectrometry, but the complex strength is rather low (K ~ 1.5 dm3/mol). Furthermore, it is shown that the presence of piperine does not increase the water solubility of curcumin, which makes it rather improbable that such a complex is the main reason for an enhanced curcumin bioavailability.

Graphic abstract
Ethical Consumption Communities Across Physical and Digital Spaces: An Exploration of Their Complementary and Synergistic Affordances
Authors: Hoelscher Vera , Chatzidakis Andreas 
Published: March 2020

AbstractWhile there is an extensive body of literature about the impact of sharing physical space on ethical consumption, and a growing body of literature that addresses the impact of digital technologies on ethical consumption, there is little research on the increasing intersections between the physical and digital realms. This study explores the distinct affordances of physical and digital spaces and how they may work in both complementary and synergistic fashions. Drawing on an ethnographic study of two ethical consumption communities in North London, UK, we explore how ethical consumers navigate and negotiate both physical and digital spaces, taking advantage of such affordances. We develop the notion ofchorophilia, or love for physical space, explore digital commitments and synergistic affordances of scaling up, and advancepolytopes,which focus on the relationality of digital-physical spaces. Implications and avenues for future research are also discussed.
Willingness to Pay for $$\hbox {CO}_2$$ Emission Reductions in Passenger Car Transport
Authors: Hulshof Daan , Mulder Machiel 
Published: March 2020

AbstractPassenger car transportation is a major contributor to global carbon emissions. Despite a range of policy measures, the European passenger car fleet remains largely running on fossil fuels. It is questionable whether the lack of emission reductions can be attributed to a lack of consumer preferences for low-emission cars because consumers may have imperfect information about cars’ emissions and the availability of clean cars remains limited. This paper investigates the preferences of consumers for emission reductions in passenger car transport. We estimate the willingness to pay of passenger car buyers for$$\hbox {CO}_2$$CO2emission reductions by means of a choice experiment amongst a sample of 1471 individuals that represents the Dutch adult population with the intention to buy a car. The main results are that the mean willingness to pay for emission reductions equals €199 per tonne, and that the majority of individuals is willing to pay more than the current market premium for two selected hybrid types. These results suggest there is a large market potential for emission reductions in passenger car transport. Our findings imply that providing consumers with trustworthy information can be considered a key policy tool for achieving emission reductions in passenger car transport.