bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of a strong desire to void on gait for incontinent and continent older community‐dwelling women at risk of falls
Authors: Paquin Marie‐Hélène , Duclos Cyril , Lapierre Nolween , Dubreucq Lucie , Morin Melanie , Meunier Jean , Rousseau Jacqueline , Dumoulin Chantal 
Published: November 2019

AbstractAimsThe fall rate in urgency urinary incontinence (UUI) and mixed UI (MUI) older women is higher when compared with that of continent women. One hypothesis is that a strong desire to void (SDV) could alter gait parameters and therefore increase the risk of falls. The aim of this study was to investigate and compare the effect of SDV on gait parameters in UUI/MUI and continent older women who experienced falls. The secondary aim was to determine the relationship between UI severity and gait parameters in incontinent women.MethodsA quasi‐experimental pilot study was conducted with two groups of healthy community‐dwelling women who experienced at least one fall in the last year: continent (n = 17; age: 74.1 ± 4.3) and UUI/MUI (n = 15; age: 73.5 ± 5.9). We recorded, analyzed, and compared spatiotemporal gait parameters for participants in each group with both SDV and no desire to void condition.ResultsA pattern of reduced velocity (P = 0.05) and stride width (P = 0.02) was observed in both groups with SDV. Incontinence severity was correlated with reduced velocity (rs = −0.63,P = 0.01), increased stance time (rs= 0.65,P = .01) and stance time variability (rs = 0.65,P = .01) in no desire to void condition and with reduced velocity (rs = −0.56,P = .03) and increased stride length variability (rs = 0.54,P = .04) in SDV condition.ConclusionsSDV reduced gait velocity and stride width regardless of continence status in older women at risk of falls. Further, UI severity in the UUI/MUI women was correlated to reduced gait velocity and increased variability. Our findings could explain the higher fall rate in this population.
The role of a new three‐dimensional ultrasound technique in the diagnosis of levator ani muscle avulsion
Authors: Montaguti Elisa , Cariello Luisa , Dodaro Maria Gaia , Rizzo Nicola , Pilu Gianluigi , Youssef Aly 
Published: November 2019

AbstractAimsTo evaluate the intermethod agreement between the tomographic ultrasound imaging (TUI), considered as the gold standard, and the OmniView‐VCI in the diagnosis of levator ani muscle (LAM) avulsion and in the measurement of levator‐urethral gap (LUG).MethodsWe acquired dynamic 4D transperineal ultrasound volumes from 114 women. Each data set was analyzed on maximal pelvic floor contraction by TUI and OmniView‐VCI techniques to check for LAM avulsion. Moreover, we measured LUG using both TUI and OmniView‐VCI, twice by an operator and once by another to assess intraobserver and interobserver reproducibility. Reproducibility and intermethod agreement were studied by means of intraclass correlation coefficient (ICC) and Cohen's kappa coefficient.ResultsIn the diagnosis of ani levator avulsion, the two techniques showed a good agreement (Cohen's κ = 0.691, 95% confidence interval [CI], 0.522‐0.860; P < .001); we also reported a good intraobserver and interobserver agreement (Cohen's κ = 0.738, 95% CI, 0.597‐0.879; P < .001, and Cohen's κ = 0.864, 95% CI, 0.750‐0.978; P < .001, respectively). LUG measurements by OmniView‐VCI technique showed high intraobserver (ICC 0.895; 95% CI, 0.866‐0.918) and interobserver (ICC 0.821; 95% CI, 0.774‐0.858) reproducibility. High intermethod agreement was demonstrated between the two methods (ICC 0.813; 95% CI, 0.764‐0.853). The area under the receiver‐operating characteristic curve of LUG in predicting avulsion was 0.931 (0.868‐0.994, 95% CI; P < .001) with 24 mm showing the best sensitivity (82%) and specificity (97%).ConclusionsOmniView‐VCI is a reliable method for LUG measurement and for levator avulsion diagnosis.
Base force element method based on the complementary energy principle for the damage analysis of recycled aggregate concrete
Authors: Wang Yao , Peng Yijiang , Kamel Mahmoud M. A. , Ying Liping 
Published: November 2019

SummaryThe finite element method (FEM) is an effective approach for exploring the failure mechanism of heterogeneous materials. According to the complementary energy principle, the use of FEM might suffer from several difficulties in terms of keeping the elements and their boundaries balanced, as well as finding interpolation functions. In this study, we introduced an efficient approach to researching the failure mechanism of the material, named base force element method (BFEM), according to complementary energy principle. Specifically, the element compliance matrix of an arbitrary quadrilateral element with four mid‐edge nodes was expressed based on the complementary energy principle. Then, the node displacement was obtained by the governing equation using the Lagrange multiplier method. In addition, both the compliance matrix and the node displacement were represented as explicit expressions without the use of Gaussian integration. A numerical model of the recycled aggregate concrete (RAC) was established according to the Monte Carlo method. A comparative sample of the digital image model was also established using digital image technology. The influences of substituting recycled aggregate and the relative mechanical properties of adhered mortar to those of new mortar on the failure mechanism of RAC were studied. The simulation results indicated that the BFEM is an effective approach to researching the damage mechanism of heterogeneous materials.
Switchable dual bonding nature in silabicyclo[1.1.0]butanes that exhibit bond stretch isomerism
Authors: Chinaroj Siwat , Iwamoto Takeaki 
Published: November 2019

AbstractSilicon analogues of bicyclo[1.1.0]butanes are known to exhibit a bond stretch isomerism where the bridgehead SiSi bond changes in both length and geometry. The bridgehead silicon atom of long bond (lb) isomers exhibits an unusual geometry where all the bonds are located on the same hemisphere, making the geometry of the bridgehead SiSi bond the so‐called inverted σ bond in contrast with the typical σ bond geometry found in the short bond (sb) isomers. Herein, the bonding nature of bridgehead SiSi bonds was theoretically investigated in detail using valence bond theory calculation at SL‐BOVB/6‐31G(d) level of theory. Our calculation demonstrates that the bond type of the bridgehead bond depends on the geometry around the bridgehead atoms with those in sb and lb isomers classified as covalent (COV) and charge‐shift (CS) bonds, respectively. The different bond types between two bond stretch isomer indicate that the bonding nature is switchable in one molecule. The detailed examination of the bond stretch isomerization in parent 1,3‐disilabicyclo[1.1.0]butane demonstrated that the enhanced CS bond nature in the lb isomer is mainly attributed to the geometry inversion of the σ bond rather than the bond elongation. This switchable dual bonding nature provides an important platform to compare covalent and CS bond on equal footing for both theoretical and experimental investigations.
Post‐discharge respiratory outcomes of children with acute respiratory distress syndrome
Authors: Boucher Valérie , Mathy Clémence , Lacroix Jacques , Émériaud Guillaume , Jouvet Philippe , Tse Sze Man 
Published: November 2019

AbstractObjectivesWhile long‐term sequelae of acute respiratory distress syndrome (ARDS) are well‐documented in adults, few studies reported post‐discharge respiratory complications in pediatric ARDS (PARDS) and none used the recent Pediatric Acute Lung Injury Consensus Conference (PALICC) diagnostic criteria. This study describes the respiratory symptoms, pulmonary function, and health resource use of PARDS survivors at 3 months post‐discharge.DesignRetrospective study.Patient SelectionChildren less than 18 years admitted to the intensive care unit of Sainte‐Justine University Health Center from 1st September 2015 to 1st July 2017, and meeting PALICC diagnostic criteria for PARDS.MethodsWe evaluated 38 of the 44 children with PARDS in the follow‐up clinic at a mean (SD) of 3.4 (2.0) months post‐discharge for respiratory symptoms, age‐appropriate pulmonary function tests (spirometry or oscillometry, maximal respiratory pressures), and all‐cause emergency department (ED) visits or rehospitalizations since discharge.ResultsFourteen (36.8%) had abnormal respiratory symptoms (most commonly cough between respiratory infections and wheezing), 7 of whom (18.4%) presented new respiratory symptoms since PARDS diagnosis. A mild‐to‐moderate restrictive pattern was observed in 3 of 10 patients who performed spirometry and mildly decreased maximal inspiratory pressures were noted in 2 of 8 patients who performed these maneuvers. Nine (23.7%) patients consulted in the ED and 4 (10.5%) were rehospitalized post‐discharge.ConclusionsDespite our cohort's limited sample size, our findings suggest that a significant proportion of PARDS survivors experience abnormal respiratory symptoms, pulmonary function deficits, and recurrent problems requiring medical attention. Larger, multicenter studies are required to identify risk factors associated with poor post‐discharge outcomes among PARDS survivors.
Genotype and phenotype evaluation of patients with primary ciliary dyskinesia: First results from Turkey
Authors: Emiralioğlu Nagehan , Taşkıran Ekim Z. , Koşukcu Can , Bilgiç Elif , Atilla Pergin , Kaya Bengisu , Günaydın Önder , Yüzbaşıoğlu Ayşe , Tuğcu Gökçen Dilşa , Ademhan Dilber , Eryılmaz Polat Sanem , Gharibzadeh Hızal Mina , Yalçın Ebru , Doğru Deniz , Kiper Nural , Alikaşifoğlu Mehmet , Özçelik Uğur 
Published: November 2019

AbstractBackground and objectivePrimary ciliary dyskinesia (PCD) is a rare and genetically heterogeneous disease and the severity of the disease related with genetic analysis has been described in some previous studies. The main aim of our study was to describe the clinical characteristics and laboratory findings of patients with genetically diagnosed PCD and to investigate the correlation between clinical, radiologic, and laboratory findings and genetic analyses of these patients.MethodThis is a cohort study in which we analyzed the clinical characteristics, laboratory findings, and genetic results of 46 patients with genetically diagnosed PCD through whole‐exome sequencing at our single center from a total of 265 patients with PCD within a 5‐year period.ResultsGenetic analysis revealed pathogenic variants in DNAH5 (n = 12 individuals, 12 families), CCDC40 (n = 9 individuals, six families), RSPH4A (n = 5 individuals, three families), DNAH11 (n = 4 individuals, four families), HYDIN (n = 5 individuals, five families), CCNO (n = 4 individuals, four families), DNAI1 (n = 2 individuals, one family), ARMC4 (n = 2 individuals, two families), TTC25 (n = 1), DNAH1 (n = 1), and CCDC39 (n = 1) genes. Although not statistically significant, the age at diagnosis was lower (median: 3 years; range, 6 months‐4 years) in patients with CCNO pathogenic variants due to the early reporting of symptoms, and the median body mass index (BMI) and BMI z scores were lower in patients at 18.7 and 16 kg/m2, and −0.78 and −1.2 with CCDC40 and CCNO pathogenic variants, respectively. The median forced expiratory flow in 1 second (FEV1%), forced vital capacity (FVC%), and forced expiratory flow (FEF)25‐75% were 53%, 64%, and 28%, respectively; these parameters were also lower in the CCDC40 group than in the other groups. There was no significant correlation between the genetic results and symptoms, radiologic findings, and microbiologic data of patients with PCD.ConclusionIn PCD, there was significant heterogeneity of lung disease, patients who had pathogenic variants in CCNO presented earlier, and those with CCDC40 and CCNO had worse lung disease, and poorer nutritional status compared with the other subgroups. We hope that whole genotype‐phenotype and clinical relationships will be identified in PCD.
Heterogeneity of human prostate carcinoma‐associated fibroblasts implicates a role for subpopulations in myeloid cell recruitment
Authors: Vickman Renee E. , Broman Meaghan M. , Lanman Nadia A. , Franco Omar E. , Sudyanti Putu Ayu G. , Ni Yang , Ji Yuan , Helfand Brian T. , Petkewicz Jacqueline , Paterakos Michael C. , Crawford Susan E. , Ratliff Timothy L. , Hayward Simon W. 
Published: November 2019

AbstractBackgroundCarcinoma–associated fibroblasts (CAF) are a heterogeneous group of cells within the tumor microenvironment (TME) that can promote tumorigenesis in the prostate. By understanding the mechanism(s) by which CAF contributes to tumor growth, new therapeutic targets for the management of this disease may be identified. These studies determined whether unique sub‐populations of human prostate CAF can be identified and functionally characterized.MethodsSingle‐cell RNA‐seq of primary human prostate CAF followed by unsupervised clustering was utilized to generate cell clusters based on differentially expressed (DE) gene profiles. Potential communication between CAF and immune cells was analyzed using in vivo tissue recombination by combining CAF or normal prostate fibroblasts (NPF) with non‐tumorigenic, initiated prostate epithelial BPH‐1 cells. Resultant grafts were assessed for inflammatory cell recruitment.ResultsClustering of 3321 CAF allows for visualization of six subpopulations, demonstrating heterogeneity within CAF. Sub‐renal capsule recombination assays show that the presence of CAF significantly increases myeloid cell recruitment to resultant tumors. This is supported by significantly increased expression of chemotactic chemokines CCL2 and CXCL12 in large clusters compared to other subpopulations. Bayesian analysis topologies also support differential communication signals between chemokine‐related genes of individual clusters. Migration of THP‐1 monocyte cells in vitro is stimulated in the presence of CAF conditioned medium (CM) compared with NPF CM. Further in vitro analyses suggest that CAF‐derived chemokine CCL2 may be responsible for CAF‐stimulated migration of THP‐1 cells, since neutralization of this chemokine abrogates migration capacity.ConclusionsCAF clustering based on DE gene expression supports the concept that clusters have unique functions within the TME, including a role in immune/inflammatory cell recruitment. These data suggest that CCL2 produced by CAF may be involved in the recruitment of inflammatory cells, but may also directly regulate the growth of the tumor. Further studies aimed at characterizing the subpopulation(s) of CAF which promote immune cell recruitment to the TME and/or stimulate prostate cancer growth and progression will be pursued.
Resilience‐based component importance measures
Authors: Wen Meilin , Chen Yubing , Yang Yi , Kang Rui , Zhang Yanbo 
Published: November 2019

SummaryThe resilience of critical infrastructures has become a major concern throughout the design, operation, and maintenance process in recent years. While traditional evaluation measures are mainly concerned with complete and timely restoration, this work considers simultaneously the cases where systems fail to recover thoroughly or timely. We define resilient limit and propose a new resilience evaluation framework for systems suffering different levels of breakdowns. Furthermore, from perspectives of topological structure, cold standby, and resilient limit of components, this paper proposes three resilience‐based importance measures, namely, structure importance, redundancy importance, and reinforcement importance. Finally, we demonstrate our method with a numerical example, illustrating its effectiveness as a tool to evaluate the influences of component resilience characteristics on the overall system.
Forschung und Innovation für den Metallleichtbau an der RWTH Aachen University
Authors: Kuhnhenne Markus , Pyschny Dominik , Brieden Matthias , Reger Vitali , Vontein Marius , Janczyk Kevin , Mehrtens Peter , Pauli Gesa 
Published: November 2019

AbstractDer vorliegende Beitrag gibt einen Überblick über die bisherigen Aktivitäten der Professur „Nachhaltigkeit im Metallleichtbau”, welche zum 1. Juli 2015 an der RWTH Aachen University eingerichtet wurde und vom Internationalen Verband für den Metallleichtbau (IFBS) unterstützt und gefördert wird. Die Professur, bekleidet von Univ.‐Prof. Dr.‐Ing. Markus Kuhnhenne, beschäftigt sich in Forschung und Lehre mit Aspekten des statisch‐konstruktiven Entwurfs, der Bauphysik und insbesondere der Nachhaltigkeit von Gebäudehüllen mit Metallleichtbauelementen. Es werden die aktuellen Entwicklungen zu energetischen Anforderungen im Gebäudebereich beschrieben, um im Anschluss die laufenden Forschungsprojekte und ‐netzwerke der Professur im Einzelnen vorzustellen.
Simplified assessment of the need to use the explicit model of reinforced concrete beam‐column joints instead of the centreline model
Authors: Costa Ricardo , Providência Paulo , Gomes Fernando 
Published: November 2019

AbstractThis paper considers the structural modeling of reinforced concrete beam‐column (RCBC) joints of unbraced framed structures. The main objective is to establish a formula that determines, for each particular situation, if the centreline joint model may be used or if an explicit model, which although more accurate is also more complex, is required. Accordingly, in order to circumvent the need to analyze the full frame and to avoid the shortcomings of empirical procedures we derive simplified classification criteria (SCC) based on the stiffness of the joint components. By applying these SCC to a given RCBC joint, it is classified either as semi‐rigid, meaning that an explicit model is required, or as nominally rigid otherwise. The determination of the parameters that are required by the SCC is fully discussed. The presented example illustrates the application of the developed SSC to particular RCBC joints, showing that its results are mainly confirmed by the analysis of the full frame to which they pertain.
Soziale Netzwerke und Behinderung – Zugang und Stabilisierung der Einbindung in den allgemeinen Arbeitsmarkt
Authors: Zapfel Stefan , Reims Nancy , Niehaus Mathilde 
Published: November 2019

Zusammenfassung

Die arbeitsmarktbezogene Behinderungs- und Rehabilitationsforschung verzichtet bisher weitestgehend auf die Verwendung von Netzwerktheorien. Ihr Analyse- und Erklärungspotenzial wurde daher auf diesem Gebiet bei weitem noch nicht ausgeschöpft.

Behinderungen stehen jedoch in engem Zusammenhang mit Genese und Stabilität von Netzwerken, die ihrerseits mit Zugang und Kontinuität von Beschäftigungsverhältnissen korrespondieren.

Wohlfahrtsstaatliche Regelungen und Institutionen (z. B. Schwerbehindertenvertretung, Betriebliches Eingliederungsmanagement, Zentrale Auslands- und Fachvermittlung der Bundesagentur für Arbeit, Einrichtungen der beruflichen Rehabilitation) bieten Menschen mit Behinderung die Möglichkeit, Netzwerkkontakte (wieder) aufzubauen oder zu erweitern und Anschluss an den Arbeitsmarkt zu finden bzw. diesen aufrechtzuerhalten.
Follow-up imaging after cryoablation of clear cell renal cell carcinoma is feasible using single photon emission computed tomography with 111In-girentuximab
Authors: van Oostenbrugge Tim J. , Langenhuijsen Johan F. , Oosterwijk Egbert , Boerman Otto C. , Jenniskens Sjoerd F. , Oyen Wim J. G. , Fütterer Jurgen J. , Mulders Peter F. A. 
Published: November 2019

Abstract
Purpose
Detection of residual or recurrent vital renal tumor on follow-up (FU) cross-sectional imaging after ablative therapy is challenging. The specific and high expression levels of carbonic anhydrase IX (CAIX) in clear cell renal cell carcinoma (ccRCC) makes it a suitable target for imaging using radiolabeled anti-CAIX antibody girentuximab. The objective of this study was to evaluate the feasibility of targeted FU imaging 1 month after cryoablation of ccRCC using single photon emission computed tomography (SPECT) after 111In-labeled girentuximab administration.

Methods
In this prospective study 16 patients underwent 111In-girentuximab-SPECT before MR-guided renal cryoablation between February 2015 and September 2018. In case of tumor targeting 111In-girentuximab-SPECT was repeated 1 month following MR-guided cryoablation. Presence of residual or recurrent vital tumor was assessed on contrast-enhanced cross-sectional imaging during further FU. The standard FU imaging protocol consisted of MRI/CT scans at 1, 3, 6, 12, and 18 months and annually thereafter.

Results
A total of 10 (63%) patients showed positive tumor targeting on 111In-girentuximab-SPECT before cryoablation and 9 ( 56%) were eligible to undergo FU SPECT. Of the 9 111In-girentuximab-SPECT FU scans, 8 (89%) were considered negative. One (11%) scan showed uptake suggestive for residual vital tumor. Six months after treatment, FU CT showed contrast enhancement suggestive for residual/recurrent disease in the ablated zone at the site of the 111In-girentuximab uptake after treatment. During a mean FU of 21 months (range 1–33) no other cases with residual/recurrent disease were detected.

Conclusion
FU imaging with 111In-girentuximab-SPECT is feasible after ccRCC cryoablation and may contribute to early detection of residual or recurrent disease.
Henneguya (Cnidaria: Myxosporea: Myxobolidae) infections of cultured barramundi, Lates calcarifer (Perciformes: Latidae) in an estuarine wetlands system of Malaysia: description of Henneguya setiuensis n. sp., Henneguya voronini n. sp. and Henneguya calcarifer n. sp.
Authors: Borkhanuddin Muhammad Hafiz , Cech Gábor , Molnár Kálmán , Shaharom-Harrison Faizah , Khoa Tran Nguyen Duy , Samshuri Muhammad Arif , Mazelan Suhairi , Atkinson Stephen D. , Székely Csaba 
Published: November 2019

AbstractExamination of 35 barramundi (Lates calcarifer) from aquaculture cages in Setiu Wetland, Malaysia, revealed a single fish infected with three Henneguya spp. (Cnidaria: Myxosporea). Characterization of the infections using tissue tropism, myxospore morphology and morphometry and 18S rDNA sequencing supported description of three new species: Henneguya setiuensis n. sp., Henneguya voronini n. sp. and H. calcarifer n. sp. Myxospores of all three species had typical Henneguya morphology, with two polar capsules in the plane of the suture, an oval spore body, smooth valve cell surfaces, and two caudal appendages. Spores were morphometrically similar, and many dimensions overlapped, but H. voronini n. sp. had shorter caudal appendages compared with H. calcarifer n. sp. and H. setiuensis n. sp. Gross tissue tropism distinguished the muscle parasite H. calcarifer n. sp. from gill parasites H. setiuensis n. sp. and H. voronini n. sp.; and these latter two species were further separable by fine-scale location of developing plasmodia, which were intra-lamellar for H. setiuensis n. sp. and basal to the filaments for H. voronini n. sp. small subunit ribosomal DNA sequences distinguished all three species: the two gill species H. setiuensis n. sp. and H voronini n. sp. were only 88% similar (over 1708 bp), whereas the muscle species H. calcarifer n. sp. was most similar to H. voronini n. sp. (98% over 1696 bp). None of the three novel species was more than 90% similar to any known myxosporean sequence in GenBank. Low infection prevalence of these myxosporeans and lack of obvious tissue pathology from developing plasmodia suggested none of these parasites are currently a problem for barramundi culture in Setiu Wetland; however additional surveys of fish, particularly at different times of the year, would be informative for better risk assessment.