bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of superfine grinding on physicochemical and antioxidant properties of soybean residue powder
Authors: Li Guanghui , Guo Weiyun , Gao Xueli , Wang Yonghui , Sun Sisheng 
Published: January 2020

AbstractSoybean residue is an underutilized, nutrient‐rich by‐product of soybean processing. To enhance its value, we subjected soybean residue to superfine grinding and measured the resulting physiochemical properties and antioxidant activities. We prepared powders with particle sizes of 115.35, 77.93, 39.38, 25.01, and 20.44 μm. As particle size decreased, the surface area (from 96.46 to 198.32 m2/kg) and swelling capacity (from 2.05 to 10.62 ml/g) increased. Conversely, we observed decreases in the surface‐number mean (from 23.07 to 11.20 μm), volume‐surface mean (from 141.70 to 27.96 μm), angles of repose (from 48.30° to 31.46°), water holding capacity (from 7.86 to 4.39 g/g), and oil binding capacity (from 1.78 to 1.42 g/g). The water solubility index and antioxidant activity (reducing power and free radical scavenging activities of 2,2‐diphenyl‐1‐picrylhydrazyl and 2,2′‐azino‐di‐(3‐ethylbenzthiazoline sulfonic acid)) improved as particle size decreased. In conclusion, superfine grinding improved some properties of soybean residue. Additionally, our findings provide theoretical support for using superfine grinding in industrial food applications.
Statistical based hydromechanical models to estimate poroelastic effects of CO2 injection into a closed reservoir
Authors: Raziperchikolaee Samin , Mishra Srikanta 
Published: January 2020

AbstractIn this study, a statistical‐based methodology is used to evaluate the poroelastic effects of injection during CO2 geologic sequestration in a closed reservoir. We constructed a series of hydromechanical models to evaluate the poroelastic effect of injection by quantifying total stress changes inside the reservoir, reservoir displacement, and surface uplift. The models are representative of closed carbonate reef reservoirs of the Michigan basin. A combination of experimental design for seven independent parameters (depth, caprock and reservoir Young's modulus, caprock and reservoir Poisson's ratio, pressure, and Biot's coefficient) and response surface modeling was used to develop statistical‐based reduced‐order models. We performed 147 numerical simulations to develop simplified models. The poroelastic model responses were captured using a standard quadratic model with full interaction terms, as well as a reduced model with only statistically significant coefficients. The interpretation of reduced‐order models, using R2 loss method, shows that while surface uplift depends mainly on the depth of the reservoir, stress increase depends mainly on Biot's coefficient. The developed statistical‐based models provide a quick tool to evaluate the poroelastic effect of injection into the closed carbonate reservoirs of the Michigan basin. Reduced‐order models were then combined with a Monte Carlo simulation to perform poroelastic uncertainty analyses and achieve a better understanding of the poroelastic performance of CO2 storage in the closed carbonate system of the Michigan basin. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd.
Forecast of long‐term EUA price probability using momentum strategy and GBM simulation
Authors: Vulin Domagoj , Arnaut Maja , Karasalihović Sedlar Daria 
Published: January 2020

AbstractCO2 storage projects are financially intensive and, without the European Union emission trading scheme that encourages CO2 emission reduction projects, they will not be cost effective, that is, feasible. Similar to the huge uncertainties involved in long‐term energy price prediction, CO2 market price is volatile. In this paper, indicators for key CO2 price changes are detected by moving average analysis. To prove the validity of the methods, geometric Brownian motion (GBM) simulations were performed for different drift and volatility values. Drift, the standard deviation of CO2 price changes and CO2 volatility were used on a daily, weekly and monthly basis for short term simulations and on a weekly basis for long term simulations. GBM simulation can help determine the probability of a European emission allowances (EUA) price, which is featured by great variations, depending on the period. Signals for periods were determined by momentum strategy, with 60 days for short and 365 days for the long moving average. They show correlation with natural gas prices, that is, EUA signals appear 13–17 months after the signal in natural gas price. Among the vast number of proposed hybrid prediction models, this correlation allows the prediction of a long‐term price trend. It seems that back‐loading measures obstructed risk estimates because they resulted in extreme price drift in some periods, as the consequence of rebalancing in supply and demand. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd.
Design of Light‐Induced Molecular Switcher for the Driver of the Quantum Cellular Automata (QCA) Based on the Transition through the Intramolecular Charge Transfer (ICT) Structure
Authors: Zilberg Shmuel 
Published: January 2020

AbstractThe design of light‐induced switcher for the molecular QCA driver was discussed. The driver‐cell with two connected chromophores was proposed as a basic model of the molecular light‐induced trigger. One of the chromophores will conjugate with a left diagonal and the second chromophore will conjugate with a right diagonal. Some differences between two chromophores can allow selective controlling of the switch to the left or to the right. The following three‐steps mechanism for QCA switcher was suggested – light‐induced transition through ICT area (a), initiation of the driver‘s polarization (b) and the beginning of the signal transition to the other cells (c). The principal physical characteristics of the driver‘s trigger was proposed, and the corresponding chemical implementation was discussed. Three kinds of processes leading to ICT were discussed as mechanisms suggested for potential switchers: 1) Irradiation leading to the ICT excited state; 2) Chemical reaction with ICT transition state; 3) Excited State Intramolecular Proton Transfer (ESIPT). The common features of these processes are the non‐radiative transition to the initial state after excitation, with the back transition going through the highly polar charge transfer (CT) area.
Cross‐lateralisation in children with attention‐deficit/hyperactivity disorder and motor skill performance
Authors: Musálek Martin , Scharoun Benson Sara M. , Lejcarova Alena , Bryden Pamela J. 
Published: January 2020

Cross‐lateralisation and increased motor difficulties have been reported in children with attention‐deficit/hyperactivity disorder (ADHD). Nevertheless, the question of how crossed (i.e. mixed preference) or uncrossed (i.e. same side preference) lateralisation impacts motor performance in children with ADHD has yet to be examined. In this study, previously validated observational measures of hand and foot preference were used to identify right‐handed children with ADHD who display cross‐ (n = 29) and uncross‐lateralisation (n = 31). An uncross‐lateralised typically developing (TD) group (n = 32) was also identified, and included as a control. Motor performance was assessed with seven valid and reliable fine and gross motor tasks performed with both preferred and non‐preferred limbs. Group, task and sex‐related effects were examined. Findings revealed that male (but not female) cross‐lateralised children with ADHD performed significantly worse, respectively, in two of the fine motor tasks (spiral tracing [p < .01], and dot filling [p < .05]). Results suggest that cross‐lateralised hand and foot preference may affect complex motor skills in male children with ADHD. Furthermore, characteristics of ADHD may manifest differently in male and female children. Findings highlight the importance of considering both hand and foot preference when targeting motor interventions for children with ADHD.
Collagen‐I/silk‐fibroin biocomposite exhibits microscalar confinement of cells and induces anisotropic morphology and migration of embedded fibroblasts
Authors: Konar Subhajit , Edwina Privita , Ramanujam Vaibavi , Arunachalakasi Arockiarajan , Bajpai Saumendra Kumar 
Published: January 2020

AbstractMicrostructural anisotropy of tumor‐associated matrix correlates with invasion of cancer cells into the surrounding matrix during metastasis. Here, we report the fabrication and characterization of a three‐dimensional (3D) silk‐fibroin/collagen‐I bio‐composite based cell‐culture model that exhibits microstructural and biochemical anisotropy. Using RGD‐deficient silk‐fibroin fibers to confine collagen‐I gelation, we develop a silk‐fibroin/collagen‐I (SFC) bio‐composite in a one‐step process allowing control over the microstructural and biochemical anisotropy and the pore‐size. Two forms of the SFC bio‐composite are reported: a sandwich (Sfc) configuration amenable to live‐cell microscopy and an unsupported membrane (Mfc) for use as a scaffold. Both microscalar and macroscalar mechanical properties of the SFC bio‐composite are characterized using atomic force microscope (AFM)‐based indentation and tensile‐testing. We find that the modulus of stiffness of both Sfc and Mfc can be controlled and falls in the physiological range of 5–20 kPa. Furthermore, the modulus of stiffness of Mfc exhibits a ~200% increase in axial direction of microstructure, as compared to lateral direction. This implies a highly anisotropic mechanical stiffness of the microenvironment. Live‐cell morphology and migration studies show that both the morphology and the migration of NIH‐3 T3 fibroblasts is anisotropic and correlates with microstructural anisotropy. Our results show that SFC bio‐composite permits proliferation of cells in both Sfc and Mfc configuration, promotes cell‐migration along the major axis of anisotropy and together with morphological and migration data, suggest a potential application of both the composite configurations as a biomimetic scaffold for tissue engineering applications.
Community‐based Youth Participatory Action Research studies with a focus on youth health and well‐being: A systematic review
Authors: Branquinho Cátia , Tomé Gina , Grothausen Teresa , Gaspar de Matos Margarida 
Published: January 2020

AbstractOn the basis of the systematic literature review, we investigate the characteristics of community‐based Youth Participatory Action Research (YPAR) programs with a focus on health and well‐being and their recommendations for future programs. The study was based on Preferred Reporting Items for Systematic Reviews and Meta‐Analyses diagram. Most included a case study design, mixed or qualitative methodology, interview as data collection, and YPAR youth in data reporting. The sample differs between studies, and most of the work took place in the United States. The stages (raise awareness, capacitation, design, motivation, implementation, evaluation, dissemination, and replication) are evident as a fundamental strategy in these programs.
Implementation of high‐resolution melting analysis of the porcupine (PORCN) gene for molecular diagnosis of focal dermal hypoplasia: Identification of a novel mutation
Authors: Martínez‐Saucedo Mirna , Ornelas‐Fuentes Carolina , Dedden Mark , Sánchez‐Urbina Rocío , Díaz‐García Héctor , Aquino‐Jarquin Guillermo , Moreno‐Salgado Rodrigo , Granados‐Riveron Javier T. 
Published: January 2020

AbstractBackgroundFocal dermal hypoplasia (FDH) is rare X‐linked dominant disease characterized by atrophy and linear pigmentation of the skin, split hand/foot deformities and ocular anomalies. FDH is caused by mutations of the Porcupine (PORCN) gene, which encodes an enzyme that catalyzes the palmitoylation of Wnt ligands required for their secretion. High resolution melting analysis (HRM) is a technique that allows rapid, labor‐efficient, low‐cost detection of genomic variants. In the present study, we report the successful implementation of HRM in the molecular diagnosis of FDH.MethodsPolymerase chain reaction and HRM assays were designed and optimized for each of the coding exons of the PORCN gene, processing genomic DNA samples form a non‐affected control and a patient complying with the FDH diagnostic criteria. The causal mutation was characterized by Sanger sequencing from an amplicon showing a HRM trace suggesting heterozygous variation and was validated using an amplification‐refractory mutation system (ARMS) assay.ResultsThe melting profiles suggested the presence of a variant in the patient within exon 1. Sanger sequencing revealed a previously unknown C to T transition replacing a glutamine codon for a premature stop codon at position 28, which was validated using ARMS.ConclusionsNext‐generation sequencing facilitates the molecular diagnosis of monogenic disorders; however, its cost–benefit ratio is not optimal when a single, small or medium size causal gene is already identified and the clinical diagnostic presumption is strong. Under those conditions, as it is the case for FDH, HRM represents a cost‐ and labor‐effective approach.
Low abundance of TFPI‐2 by both promoter methylation and miR‐27a‐3p regulation is linked with poor clinical outcome in gastric cancer
Authors: Geng Guangyong , Liu Xin , Xu Aman , Lu Zhen , Chen Kaiwei , He Juntong , Qi Dongjiang , Yuan Xiao 
Published: January 2020

AbstractBackgroundThe tumor suppressor role of tissue factor pathway inhibitor 2 (TFPI‐2) has been reported in various tumors. The present study aimed to improve the understanding of the oncogenic properties of TFPI‐2 in gastric cancer.MethodsRelative expression of TFPI‐2 was determined by a real‐time polymerase chain reaction (PCR) and western blotting, respectively. Cell viability was measured via a cell counting kit‐8 assay and proliferation was evaluated by a colony formation assay. Cell apoptosis was assessed with a caspase‐3 activity kit and invasion was evaluated by a transwell chamber assay. The methylation level of TFPI‐2 promoter was assayed by methylation‐specific PCR. The regulatory effect of miR‐27a‐3p on TFPI‐2 was analyzed with a luciferase reporter assay. The direct association between miR‐27a‐3p and TFPI‐2 was shown by biotin‐labelling pulldown.ResultsTFPI‐2 was down‐regulated in gastric cancer, which associated with an unfavorable prognosis clinically. Ectopic introduction of TFPI‐2 greatly compromised cell viability, colony formation and invasive capacity, and also induced cell apoptosis simultaneously. The promoter region of TFPI‐2 was extensively methylated in gastric cancer tissues compared to normal tissues, suggesting the epigenetic inhibition of TFPI‐2 expression. We further identified that TFPI‐2 functioned as sponge RNA against miR‐27a‐3p. Most importantly, miR‐27a‐3p‐specific inhibitor significantly exerted a tumor suppressor function akin to TFPI‐2 itself, and the anti‐tumoral activities were completely abolished by TFPI‐2 knockdown.ConclusionsWe found that the epigenetically suppressed TFPI‐2 compromised sponging effects with respect to miR‐27a‐3p in gastric cancer, which consequently and mechanistically contributed to the tumor biology of gastric cancer.
NIS‐promoted multicomponent reaction of 2‐aminopyridines with aldehydes and nitromethane for the synthesis of 3‐nitroimidazo[1.2‐a]pyridines
Authors: Sun Jinwei , Yang Xinrui , Liu Yun , Wang Yi , Pan Yi 
Published: January 2020

AbstractAn efficient synthesis of 3‐nitroimidazo[1,2‐a]pyridines has been developed via N‐iodosuccinimide (NIS)‐mediated multicomponents reaction of 2‐aminopyridines, aldehydes, and nitromethane under metal‐free conditions. This protocol has many advantages such as broad substituent scope, mild and eco‐friendly conditions, high step economy, and good yields.
Cyclization ofN‐benzyl cyanoacetamide: Novel synthesis and biological activity of pyrrole, pyrimidine, and pyran derivatives
Authors: Hamed Eman O. , Assy Mohamed G. , Shalaby Adel M. , Sayed Rawda E. 
Published: January 2020

AbstractHeteroannulation ofN‐Benzyl cyanoacetamide1to a new series of heterocycles has been developed. Thus, reaction of1with different polarized π systems afforded pyrrolo4, pyridone6, pyridine8, and diazapene10derivatives, respectively.N‐Benzyl cyanoacetamide that undergo condensation reaction with salicylaldehyde yielded pyran derivative11. Nitrosation of11furnished condensed pyran13. Compound11reacted with benzaldehyde, carbon disulfide (cyclizing agent), and ammonium thiocyanate to provide pyrane17, thiazine18, and thiourea20derivatives, respectively. Cinnamoyl isothiocyanate was reacted with compound11to produce non‐isolable thiourea derivative21. The newly synthesized compounds have been characterized by infrared (IR), proton nuclear magnetic resonance (1H NMR), and carbon nuclear magnetic resonance (13C NMR) spectral data. The compounds were then evaluated for antibacterial and anticancer activities.
Interreader Agreement of Liver Imaging Reporting and Data System on MRI: A Systematic Review and Meta‐Analysis
Authors: Kang Ji Hun , Choi Sang Hyun , Lee Ji Sung , Park Seong Ho , Kim Kyung Won , Kim So Yeon , Lee Seung Soo , Byun Jae Ho 
Published: January 2020

BackgroundUse of the Liver Imaging Reporting and Data System (LI‐RADS) is increasing, but the reported results for interreader agreement seem quite variable.PurposeTo systematically determine the interreader agreement of LI‐RADS on magnetic resonance imaging (MRI) and to determine the sources of heterogeneity between the reported results.Study TypeSystematic review and meta‐analysis.SubjectsFifteen original articles with 2968 lesions.Field Strength1.5T and 3.0T.AssessmentTwo reviewers independently performed the data extraction. The reviewers identified and reviewed the original articles reporting the interreader agreement of LI‐RADS using MRI.Statistical TestsThe meta‐analytic pooled intraclass correlation coefficient (ICC) for lesion size and kappa value (κ) for major features (arterial‐phase hyperenhancement [APHE], nonperipheral washout [WO], enhancing capsule [EC]) and LI‐RADS categorization (LR) were calculated using the random‐effects model. Sensitivity analysis and meta‐regression analysis were performed to explore the cause of study heterogeneity.ResultsThe meta‐analytic pooled ICC of lesion size was 0.97 (95% confidence interval [CI], 0.94–1.00). Meta‐analytic pooled κ of APHE, WO, EC, and LR were 0.72 (95% CI, 0.62–0.82), 0.69 (95% CI, 0.60–0.78), 0.66 (95% CI, 0.58–0.74), and 0.70 (95% CI, 0.56–0.85), respectively. Substantial study heterogeneity was noted in all five variables (I2 ≥ 89.1%, P < 0.001). Study design, type, and clarity of blinding review were factors that significantly influenced study heterogeneity (P ≤ 0.05).Data ConclusionLI‐RADS demonstrated overall substantial interreader agreement for major features and the category on MRI, but showed heterogeneous results between studies.Level of Evidence3Technical Efficacy Stage2 J. Magn. Reson. Imaging 2020;52:795–804.
Effectiveness of scaling and root planing with and without adjunct probiotic therapy in the treatment of chronic periodontitis amongshammausers and non‐users: A randomized controlled trial
Authors: Vohra Fahim , Bukhari Ishfaq A. , Sheikh Saeed A. , Albaijan Refal , Naseem Mustafa , Hussain Mudassir 
Published: January 2020

AbstractBackgroundEffectiveness of scaling and root planing (SRP) with/without adjunct probiotic (Lactobacillus reuteri) treatment towards the reduction in periodontal inflammatory parameters (clinical attachment loss [AL], marginal bone loss [MBL], plaque index [PI], and bleeding on probing [BOP] inshammausers and non‐users [controls] with chronic periodontitis [CP]) remains uninvestigated. The aim of the present randomized controlled trial was to compare the efficacy of SRP with and without adjunct probiotic therapy (PT) in the treatment of CP amongshammausers and controls (individuals not using tobacco in any form).MethodsThe study was conducted in accordance with the Consolidated Standards of Reporting Trials guidelines. Patient demographics were recorded using a questionnaire. Therapeutically, patients were allotted into four groups as follows: 1) group 1: Shamma chewers that underwent SRP alone; 2) group 2: Shamma‐chewers that underwent SRP + PT; 3) group 3: Non‐chewers that underwent SRP alone; and 4) group 4: Non‐chewers that underwent SRP + PT. Periodontal parameters (PI, BOP, PD, clinical AL and mesial and distal MBL) were measured on all teeth except third molars at baseline and at 3‐ and 6‐month follow‐ups. Level of significance was set atP < 0.05.ResultsIn total, 31, 32, 31, and 33 individuals were included in groups 1, 2, 3, and 4, respectively. Amongshammausers, there was no significant difference in the scores of PI, BOP, PD, clinical AL and MBL when SRP was performed with/without adjunct PT. Amongst controls, SRP with adjunct PT was more effective in reducing PI (P < 0.05), BOP (P < 0.05) and PD (P < 0.05) at 3‐month follow‐up. There was no significant difference in periodontal parameters at 3‐ and 6‐month follow‐ups in patients that underwent SRP with and without adjunct PT.ConclusionsHabitualshammause compromises the outcome of SRP in patients with CP. Among patients that do not use any form of ST product, SRP is an effective treatment modality for the treatment of CP, and this relationship is independent of use of adjunct PT.
Long term crop management effects on soil organic carbon, structure, and water retention in a cropland soil in central Ohio, USA
Authors: Yadav Surender Singh , Guzman Jose G. , Meena Ram Swaroop , Lal Rattan , Yadav Gulab Singh 
Published: January 2020

AbstractThe objective of this study was to determine 13‐year management effects on soil properties between a corn–soybean (Zea mays–Glycine max) cropping system (CSRS) and vegetable production systems (VPS) on a soil in central Ohio. Three treatments included in the VPS were: (1) addition of wood chips, (2) permanent raised beds (PRB) with black polyethylene film (20 μm thick), and (3) bare soil surface (BSS). Additionally, (4) animal manure was applied in all CSRS and VPS treatments except for the wood chips (WCP) added plot in the VPS. Research data from the study show that relatively more soil organic carbon (SOC) stock in the 0–20 cm soil depth of the BSS treatment (100.6 Mg ha−1) was primarily due to differences in the type of soil amendments applied. For example, composted poultry manure was applied in the BSS and PRB plots, compared with input of fresh dairy manure mixed with straw being applied in the CSRS. Furthermore, soil management practices that aided in avoiding or reducing soil compaction (i.e., PRB or application of WCP in the surface) resulted in the overall improvement in soil structure and water retention, compared with that under chisel and disc ploughing done in the CSRS. The highest plant available water capacity (1.79 cm) was observed in the CSRS compared with 0.97 cm under BSS and PRB plots. These trends suggest that the type and amount of animal manure is critical to increasing SOC stocks in intensively cultivated VPS and CSRS in central Ohio, while also improving soil structure and water retention.