bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanosensing of a Graphene Flake on a Bent Beam
Authors: Hu Yue , Leng Jiantao , Chang Tienchong 
Published: November 2020

Abstract
The ability of mechanosensing is essential for intelligent systems. Here we show by molecular dynamics (MD) simulations that a graphene flake on a bent beam exhibits amazing mechanosensing behavior, termed flexotaxis. The graphene flake can perceive the beam bending gradient which indeed leads to a gradient of atomic density that produces a driving force on the flake toward the direction of increasing density. An analytical model is developed to further confirm the mechanism, and the simulation results can be well reproduced by the model. Our findings may have general implications not only for the potential applications of graphene as sensing elements in nanoscale intelligent devices but also for the exploration of mechanosensing capability of other two-dimensional materials.
Sizing Optimization of Pneumatic Actuation Systems Through Operating Point Analysis
Authors: Vigolo Vinícius , De Negri Victor Juliano 
Published: November 2020

Abstract
This paper reports a study on the static and dynamic behavior of pneumatic actuation systems, resulting in a comprehensive view of the influence of the system parameters on the energy efficiency and dynamic performance. The operating point approach based on the steady-state analysis of a pneumatic actuation system is used for developing analytical expressions to describe the relationship between the piston diameter and the system performance, including displacement time, stroke end velocity, and energy efficiency. The validity of the proposed equations is demonstrated by comparison with results from a test rig. Sensitivity analysis using a nonlinear dynamic simulation model indicated that a specific operating region exists, where good energy efficiency and the maximum dynamic performance are achieved. Moreover, the results show that an oversized system becomes more inefficient in both energetic and dynamic aspects. The results obtained provide a very consistent foundation for developing a method for pneumatic system sizing.
National Institute for Health Research Health Informatics Collaborative: development of a pipeline to collate electronic clinical data for viral hepatitis research
Authors: Smith David Anthony , Wang Tingyan , Freeman Oliver , Crichton Charles , Salih Hizni , Matthews Philippa Clare , Davies Jim , Várnai Kinga Anna , Woods Kerrie , Jones Christopher R. , Glampson Ben , Mulla Abdulrahim , Mercuri Luca , Shaw A. Torm , Drumright Lydia N , Romão Luis , Ramlakan David , Higgins Finola , Weir Alistair , Nastouli Eleni , Agarwal Kosh , Gelson William , Cooke Graham S. , Barnes Eleanor 
Published: November 2020

ObjectiveThe National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) is a programme of infrastructure development across NIHR Biomedical Research Centres. The aim of the NIHR HIC is to improve the quality and availability of routinely collected data for collaborative, cross-centre research. This is demonstrated through research collaborations in selected therapeutic areas, one of which is viral hepatitis.DesignThe collaboration in viral hepatitis identified a rich set of datapoints, including information on clinical assessment, antiviral treatment, laboratory test results and health outcomes. Clinical data from different centres were standardised and combined to produce a research-ready dataset; this was used to generate insights regarding disease prevalence and treatment response.ResultsA comprehensive database has been developed for potential viral hepatitis research interests, with a corresponding data dictionary for researchers across the centres. An initial cohort of 960 patients with chronic hepatitis B infections and 1404 patients with chronic hepatitis C infections has been collected.ConclusionFor the first time, large prospective cohorts are being formed within National Health Service (NHS) secondary care services that will allow research questions to be rapidly addressed using real-world data. Interactions with industry partners will help to shape future research and will inform patient-stratified clinical practice. An emphasis on NHS-wide systems interoperability, and the increased utilisation of structured data solutions for electronic patient records, is improving access to data for research, service improvement and the reduction of clinical data gaps.
Motor competence assessments for children with intellectual disabilities and/or autism: a systematic review
Authors: Downs Samantha J , Boddy Lynne M , McGrane Bronagh , Rudd James R , Melville Craig A , Foweather Lawrence 
Published: November 2020

ObjectiveGross motor competence is essential for daily life functioning and participation in physical activities. Prevalence of gross motor competence in children with intellectual disabilities (ID) and/or autism is unclear. This systematic review aimed to identify appropriate assessments for children with ID and/or autism.Design & data sourcesAn electronic literature search was conducted using the EBSCOhost platform searching MEDLINE, Education Research Complete, ERIC, CINAHL Plus and SPORTDiscus databases.Eligibility criteriaIncluded studies sampled children with ID and/or autism aged between 1 and 18 yrs, used field-based gross motor competence assessments, reported measurement properties, and were published in English. The utility of assessments were appraised for validity, reliability, responsiveness and feasibility.ResultsThe initial search produced 3182 results, with 291 full text articles screened. 13 articles including 10 assessments of motor competence were included in this systematic review. There was limited reporting across measurement properties, mostly for responsiveness and some aspects of validity. The Bruininks–Oseretsky Test of Motor Proficiency-2 followed by The Test of Gross Motor Development-2 demonstrated the greatest levels of evidence for validity and reliability. Feasibility results were varied, most instruments required little additional equipment (n=8) and were suitable for a school setting, but, additional training (n=7) was needed to score and interpret the results.ConclusionThis review found the BOT-2 followed by the TGMD-2 to be the most psychometrically appropriate motor competency assessments for children with ID and/or autism in field-based settings. Motor competence assessment research is limited for these cohorts and more research is needed.PROSPERO registration numberCRD42019129464.
Trapping of null geodesics in slowly rotating spacetimes
Authors: Vrba Jaroslav , Urbanec Martin , Stuchlík Zdeněk , Miller John C. 
Published: November 2020

AbstractExtremely compact objects containing a region of trapped null geodesics could be of astrophysical relevance due to trapping of neutrinos with consequent impact on cooling processes or trapping of gravitational waves. These objects have previously been studied under the assumption of spherical symmetry. In the present paper, we consider a simple generalization by studying trapping of null geodesics in the framework of the Hartle–Thorne slow-rotation approximation taken to first order in the angular velocity, and considering a uniform-density object with uniform emissivity for the null geodesics. We calculate effective potentials and escape cones for the null geodesics and how they depend on the parameters of the spacetimes, and also calculate the “local” and “global” coefficients of efficiency for the trapping. We demonstrate that due to the rotation the trapping efficiency is different for co-rotating and retrograde null geodesics, and that trapping can occur even for$$R>3GM/c^2$$R>3GM/c2, contrary to what happens in the absence of rotation.
Alternative Splicing of FN (Fibronectin) Regulates the Composition of the Arterial Wall Under Low Flow
Authors: Murphy Patrick A. , Jailkhani Noor , Nicholas Sarah-Anne , Del Rosario Amanda M. , Balsbaugh Jeremy L. , Begum Shahinoor , Kimble Amy , Hynes Richard O. 
Published: November 2020

Objective:
Exposure of the arterial endothelium to low and disturbed flow is a risk factor for the erosion and rupture of atherosclerotic plaques and aneurysms. Circulating and locally produced proteins are known to contribute to an altered composition of the extracellular matrix at the site of lesions, and to contribute to inflammatory processes within the lesions. We have previously shown that alternative splicing of FN (fibronectin) protects against flow-induced hemorrhage. However, the impact of alternative splicing of FN on extracellular matrix composition remains unknown.

Approach and Results:
Here, we perform quantitative proteomic analysis of the matrisome of murine carotid arteries in mice deficient in the production of FN splice isoforms containing alternative exons EIIIA and EIIIB (FN-EIIIAB null) after exposure to low and disturbed flow in vivo. We also examine serum-derived and endothelial-cell contributions to the matrisome in a simplified in vitro system. We found flow-induced differences in the carotid artery matrisome that were impaired in FN-EIIIAB null mice. One of the most interesting differences was reduced recruitment of FBLN1 (fibulin-1), abundant in blood and not locally produced in the intima. This defect was validated in our in vitro assay, where FBLN1 recruitment from serum was impaired by the absence of these alternatively spliced segments.

Conclusions:
Our results reveal the extent of the dynamic alterations in the matrisome in the acute response to low and disturbed flow and show how changes in the splicing of FN, a common response in vascular inflammation and remodeling, can affect matrix composition.
From Idolatry to Religions: the Missionary Discourses on Hinduism and Buddhism and the Invention of Monotheistic Confucianism, 1550-1700
Authors: Rubiés Joan-Pau 
Published: November 2020

Abstract
The emergence of a European discourse to distinguish, analyze, and historicize various non-Biblical religious traditions within Asia involved a significant amplification of the concept of idolatry. The Jesuit experience of Japanese Buddhism in the second half of the sixteenth century posed a particular challenge, because of its overt atheism. The patristic models of Christian apologetics, based on distinguishing elite monotheism from popular religion in ancient paganism, had been useful in India, but in Japan had to be replaced by a system where the elite cultivated an atheistic form of esoteric monism. When focusing their dialectical firepower upon the doctrines of double truth and non-theistic monism, the Jesuits, led by Alessandro Valignano, were in fact responding to the doctrinal distinctiveness of East Asian Buddhism, notably the emphasis on provisional teachings, on the one hand, and Buddha-nature, on the other. When in China Ricci decided to classify the Confucian literati as civil philosophers rather than as a religious elite, he also transferred Valignano’s critique of Buddhist pantheism to specifically Neo-Confucian doctrines, distinct from the supposed monotheism of the original Confucians.
Federal Proportionality Review in EU Law: Whose Rights are they Anyway?
Authors: Harvey Darren 
Published: November 2020

Abstract
The principle of proportionality has always operated as a means of protecting individuals from excessive uses of public power. When situated alongside the principles of conferral and subsidiarity, proportionality also possesses a federal dimension. In this guise, the principle limits the intensity of EU intervention in order to protect national regulatory autonomy. This federal element of proportionality has featured in recent Court of Justice of the European Union (cjeu) cases. For example, Member States have challenged European Union (EU) legislation for imposing disproportionate social and economic costs in their particular States. This article considers whether individuals can similarly challenge EU legislation for disproportionately interfering with the regulatory autonomy of the Member States? Having considered this question from the perspective of US federalism, it is argued that individuals are actually articulating “Member States’ rights” in such cases. In so doing, attention is drawn to the question of whose rights and interests are really being articulated and balanced in these disputes.
Proportionality and Human Rights Protection in International Investment Arbitration: What’s Left Hanging in the Balance?
Authors: Davitti Daria 
Published: November 2020

Abstract
This article focuses on the proportionality analysis carried out by international investment tribunals when the protection of foreign investment adversely impacts the protection of human rights. International investment arbitrators are increasingly called to adjudicate awards which require a ‘balancing’ between the so-called rights of investors, protected as they are by relevant international investment agreements (iia), and the rights of third parties affected by foreign investment. Such balancing often entails, at its core, a controversial juxtaposition between investment protections and human rights protections. In this article, I argue that a balancing between investors’ rights and human rights is neither possible nor desirable. This argument is crucial to demystify existing assumptions surrounding the use of balancing and proportionality in international investment arbitration as a way of successfully reconciling competing interests as well as conflicting protection obligations vested upon a host State.
The Discourse of Proportionality and the Use of Force: International Law and the Power of Definition
Authors: Bak McKenna Miriam 
Published: November 2020

Abstract
Foregrounding standards like ‘proportionality’ and ‘necessity’ have come to assume a central place in the international legal vocabulary for assessing the legitimacy of war. In both ethical and practical terms, the shift towards common standards provides a useful vernacular to assess military operations. But the question remains: how should these terms be interpreted and applied and by whom? Simultaneously, debates over the definitional boundaries of the legal concept of war and its attendant categories (e.g. lawful military objects, protected zones, combatants, civilians) have arisen in many contexts, leaving room for different and conflicting interpretations, often to the detriment of marginalised groups and weaker States. This article examines the ambivalences, complexities and contestations that have arisen in the move towards broader and subjective discourses of law and war, through the lens of proportionality.
Rebutting Four Arguments in Favour of Resolving ius cogens Norm Conflicts by Means of Proportionality Tests
Authors: Jeutner Valentin 
Published: November 2020

Abstract
The text casts doubt on the utility of proportionality tests to resolve conflicts between peremptory norms of public international law with reference to an argument advanced by João Ernesto Christófolo. Responding to Christófolo, the text maintains that subjecting conflicts between peremptory norms to a proportionality analysis entails judicial law-making, does not safeguard the interests protected by peremptory norms and that the use of proportionality tests cannot be justified with reference to the desired completeness of international law. Instead, the text argues that conflicts between peremptory norms should be dealt with head-on by openly acknowledging the existence of an irresolvable norm conflict and that, if at all, proportionality tests must be applied with utmost care to avoid that the interests of those undertaking a proportionality analysis prevail over the interests of those whose interests the balanced norms in questions are intended to protect.
‘The Curious Ways to Observe Weight in Water’: Thomas Harriot and His Experiments on Specific Gravity
Authors: Clucas Stephen 
Published: November 2020

Abstract
This paper explores the experiments of the English mathematician Thomas Harriot (1560-1621) on specific gravity in the years 1600-1605, as recorded in a series of manuscript notes in British Library Add. MS 6788. It examines the programme of reading undertaken by Harriot before (or during) these experiments (including works by Jean Bodin, Giovanni Battista della Porta, Gerard de Malynes, Gaston du Clo, and Juan Bautista Villalpando), and describes a series of experiments conducted by him which compared the weight of a wide variety of substances in air and water. Harriot’s work is compared to that of his contemporary Marino Ghetaldi (1568-1626) in Promotus Archimedis (1603), and the work of both mathematicians can be positioned in the context of sixteenth-century mathematical responses to the famous problem posed by Hiero, King of Syracuse to Archimedes (as related by Vitruvius). Harriot’s use of proportional mathematics (especially the “rule of alligation”) in his experimental work and his application of this technique to problems in the alloying of metal and chymical analysis is examined in detail.
Why, Exactly, Is Climate Change a Wicked Problem?
Authors: Conradie Ernst M. 
Published: November 2020

Abstract
This contribution explores the assertion that climate change may be described as a “wicked problem.” It notes that the term was introduced in the context of the management sciences where a managerial ethos prevailed and where moral connotations were excluded. Subsequent references to climate change as a wicked problem maintained both these features. Yet, if climate change not only poses technological, economic, and political problems but also has moral and, indeed, spiritual challenges—as is widely maintained—then such moral connotations cannot be avoided. The description of a problem as wicked then becomes part of the problem. It is argued that the term is best understood as one used in jest, so that if we seek to define a problem’s wickedness in a conceptually precise way, we are missing the joke. The major moral dimensions of the challenges posed by climate changes should be taken seriously, but perhaps there is no need to take the term wicked problems all that seriously. What should not be laughed off is the managerial ethos that presumes that the challenges posed by climate changes can be addressed “exactly” through climate engineering or even social engineering.
Overcoming Reconciliation as a Wicked Problem
Authors: Solomons Demaine 
Published: November 2020

Abstract
This contribution provides clues as to why (the quest for) reconciliation in South Africa fits the broad definition of a wicked problem. Popularized by Horst Rittel and Melvin Webber (1973), wicked problem refers to something that is either too difficult or nearly impossible to resolve. It is abundantly clear from the available literature that reconciliation is understood in very different ways. Not only is there a lack of conceptual clarity, but strategies aimed at working towards this ideal reveal or produce new problems as an unintended consequence. Some strategies approach the discourse for the purpose of political expediency, while others are more interested in its theological (or existential) properties. This tension is referenced as the dominant split between heaven and earth. Notwithstanding the complexity of the problem, this contribution alludes to the limitations of such approaches if those who propagate them insist that such views remain mutually exclusive. Building on the theology of Allan Aubrey Boesak and Curtiss Paul DeYoung (2012), this contribution is an attempt to avoid the polarization of such views and highlight the fundamental asymmetry between divine and human action. This is underscored by the work of Christ through which God reconciled the world to himself (2 Cor. 5:19) and the ministry of reconciliation in society. In taking this approach, one avoids the tendency to provide superficial answers to a complex (wicked) problem.
Statistical Postprocessing for Weather Forecasts: Review, Challenges, and Avenues in a Big Data World
Authors: Vannitsem Stéphane , Bremnes John Bjørnar , Demaeyer Jonathan , Evans Gavin R. , Flowerdew Jonathan , Hemri Stephan , Lerch Sebastian , Roberts Nigel , Theis Susanne , Atencia Aitor , Ben Bouallègue Zied , Bhend Jonas , Dabernig Markus , De Cruz Lesley , Hieta Leila , Mestre Olivier , Moret Lionel , Plenković Iris Odak , Schmeits Maurice , Taillardat Maxime , Van den Bergh Joris , Van Schaeybroeck Bert , Whan Kirien , Ylhaisi Jussi 
Published: November 2020

AbstractStatistical postprocessing techniques are nowadays key components of the forecasting suites in many national meteorological services (NMS), with, for most of them, the objective of correcting the impact of different types of errors on the forecasts. The final aim is to provide optimal, automated, seamless forecasts for end users. Many techniques are now flourishing in the statistical, meteorological, climatological, hydrological, and engineering communities. The methods range in complexity from simple bias corrections to very sophisticated distribution-adjusting techniques that incorporate correlations among the prognostic variables. The paper is an attempt to summarize the main activities going on in this area from theoretical developments to operational applications, with a focus on the current challenges and potential avenues in the field. Among these challenges is the shift in NMS toward running ensemble numerical weather prediction (NWP) systems at the kilometer scale that produce very large datasets and require high-density high-quality observations, the necessity to preserve space–time correlation of high-dimensional corrected fields, the need to reduce the impact of model changes affecting the parameters of the corrections, the necessity for techniques to merge different types of forecasts and ensembles with different behaviors, and finally the ability to transfer research on statistical postprocessing to operations. Potential new avenues are also discussed.
Effect of external diaphragmatic pacing therapy on patients with chronic cor pulmonale: a randomized, controlled trial
Authors: Liu Yongchao , Abula Nuer Maimaiti , Wang Qixing , Tong Nana , Zhang Xiangyu , Aisha Aisikaer , Wang Sheng 
Published: November 2020

Objectives This study aimed to evaluate the effects of external diaphragmatic pacing (EDP) on patients with chronic cor pulmonale (CCP). Methods Fifty patients with CCP were enrolled in Kashgar Prefecture Second People’s Hospital in Xinjiang Uygur Autonomous Region of China from 2016 to 2017. The patients were randomized into a group that received anti-CCP therapy (negative control group) or a group that received additional EDP treatment (EDP group). We recorded and compared maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and the 6-minute walking test between the two groups on the first and tenth days of treatment. Results Ten days after treatment began, MIP, FVC, and the 6-minute walking test were significantly improved in both groups. Importantly, MIP and FVC were significantly higher in the EDP group compared with the control group on the tenth day. Conclusion In addition to treatment for CCP, these patients can obtain extra benefit by using EDP treatment.