bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring social innovation through co-creation in rural India using action research
Authors: Cornet Souresh , Barpanda Saswat 
Published: June 2020

Purpose
Social innovation (SI) has been promoted by policymakers for addressing all kinds of social issues in the context of diminishing government resources. It is, however, difficult to assess the efficiency of SI-based public policies, as the process of SI itself remains largely nebulous. The purpose of this paper is to better understand this process with a focus on its early stage, until the point of identifying a socially innovative idea and in the context of disadvantaged rural communities in India.

Design/methodology/approach
Co-creation workshops were facilitated to generate socially innovative solutions in villages, using co-design technique. Following an action research approach, qualitative data was collected to produce case studies.

Findings
This study found that SI was appropriate for addressing development challenges in rural India. Facilitated co-creation was successful in involving all citizens and effective in generating SI. The authors developed a framework of generating SI through co-creation that gives a more precise understanding of the SI process.

Practical implications
The authors propose a method for co-creating SI that can be of significant use for practitioners. Findings can help design better and more socially impactful public policies.

Originality/value
This paper focusses on understanding the process of generating SI, using a participatory approach. It is the first work that has been conducted of this sort in the context of Indian rural villages.
Dimensions of social capital and learning culture: a case of an IT organization
Authors: Srirama Mamatha V. , Iyer Parameshwar P. , Reddy Hariprasad 
Published: June 2020

PurposeEarlier studies of social capital have focused on its influence on various aspects of business. There is substantial void in the literature on how social capital enables learning culture in organizations. The purpose of this paper is to explore direct and indirect relations between dimensions of social capital and learning culture in the organizational context.Design/methodology/approachA survey-based research was conducted in which the questionnaire based on the Dimensions of Learning Organization Questionnaire (DLOQ) and social capital was used. Participants in this study were employees from an IT organization based in India. Data was subjected to structural equation modeling to understand causal relations between social capital and learning culture.FindingsThis empirical study emphatically shows that parameters of social capital positively influence individual learning. Results show that shared vision, shared narratives in the cognitive dimension; trust and identification in the relational dimension; and mutual confiding in the structural dimension have a positive influence on individual learning.Originality/valueFindings in this paper indicate that a culture of learning in organizations starts with individuals and it can be fueled and sustained by social capital embedded within the organization if managers focus on enabling the factors identified in this study through policies and practices.
Luxury shopping tourism: views from Chinese post-1990s female tourists
Authors: Li Cui Stacey , Zhang Carol Xiaoyue , Chen Xiaoqing , Wu Meng Shan Sharon 
Published: June 2020

Purpose
This study aims to explore how the concept of extended self-influences luxury shopping tourism consumption among Chinese tourists. It explores why luxury shopping is important for Chinese tourists. Specifically, this study focuses on a strategically important emerging market segment: post-1990s female Chinese tourists.

Design/methodology/approach
To explore the link between the extended self and luxury shopping tourism consumption among post-1990s Chinese female tourists, this study adopted a qualitative and interpretive approach. A total of 22 semi-structured in-depth interviews were carried out to collect the data.

Findings
This qualitative inquiry found that luxury shopping during overseas holidays has some subtle differences from luxury shopping in China, as the conceptualisation of luxury is highly context-based. Through a focus on gender and generational differences, the current study reveals that the idea of individuality has started to influence their luxury purchases.

Practical implications
The study shows how different selves are associated with luxury shopping. It thus provides empirical evidence regarding the reasons behind their motivation, especially for shopping overseas to get a good price and an exclusive and enjoyable luxury shopping experience abroad. Also, it was found that curiosity about buying luxury products is viewed as less favoured and logical shopping will be a future trend. Individuality is becoming a trend for younger consumers.

Originality/value
Theoretically, by linking the “extended self” with luxury shopping tourism, this study provides the social-psychological aspects of luxury shopping tourism. Instead of focusing on particular destinations, this study provides compressed but also focused inquiries to explore how the concept of the self-influences post-1990s female Chinese tourists’ shopping consumption while on holiday, and how this luxury shopping experience influences their concept of the self.
Children in the digital world: exploring the role of parental–child attachment features in excessive online gaming
Authors: Malik Anjali , Nanda Ambika Prasad , Kumra Rajeev 
Published: June 2020

Purpose
The marketing of immersive and competitive online gaming products has proliferated in recent times. Consumption has also shown a substantial increase, especially among children. Such elevated levels of gaming have adversely affected children’s overall well-being. This paper aims to examine the role of parental attachment variables in enhancing children’s self-control behavior in counteracting the adverse effects of excessive gaming. The role of gender in excessive gaming is also studied.

Design/methodology/approach
A conceptual framework is tested that examines the direct relationship of features of parental attachment with excessive online gaming behavior and an indirect effect through the mediation of a child’s self-control construct using structural equation modeling.

Findings
The findings indicate that parental attachment through self-control can play a significant role in limiting excessive gaming behavior among vulnerable young gamers. Excessive gaming behavior was more pronounced for boys than girls. Alienation explained excessive gaming behavior among girls, while communication was significant for boys, but in a reversed direction.

Research limitations/implications
All possible antecedent variables from the literature, like parental rearing style, that may further contribute to developing a comprehensive theoretical framework could not be studied.

Practical implications
The study suggests that the priming of children achieved through parental attachment relationships may help prevent excessive gaming behavior among vulnerable young gamers.

Originality/value
This study addresses the gap in the understanding of parental attachment features related to excessive gaming among different genders. It also establishes the role of the intervening mechanism of a child’s self-control in regulating behavior in relation to excessive gaming in the Indian context.
Interaction of Escherichia coli and its culture supernatant with Vibrio vulnificus during biofilm formation
Authors: Ohn Han‐Min , Mizuno Tamaki , Sudo Yuki , Miyoshi Shin‐Ichi 
Published: June 2020

AbstractVibrio vulnificus is a foodborne pathogen causing septicemia with high mortality rate. In this study, we explored how Escherichia coli, one of the commensal bacteria in the human gastrointestinal tract, can interact with V. vulnificus. Our study results show that the amount of biofilm produced by V. vulnificus was reduced in the presence of E. coli ATCC 35218, although the growth of V. vulnificus L‐180 remained unaffected. We also detected an antibiofilm effect of E. coli culture supernatant against V. vulnificus, which could not be reduced even after heat treatment. These findings indicate that E. coli and its culture supernatant may be suitable to prevent biofilm formation by V. vulnificus. By contrast, live cells of V. vulnificus could reduce the amount of preformed E. coli biofilm, but its culture supernatant could not. This suggests that the cell‐associated factors contribute toward reduction in E. coli biofilm. Therefore, we speculate that ingestion of an infectious dose of V. vulnificus might induce dislodging of the commensal bacteria from the intestinal epithelia and thus can colonize to initiate the infection.
Acute hypotensive effect of diminazene aceturate in spontaneously hypertensive rats: role of NO and Mas receptor
Authors: Sartório Carmem Luíza , Pimentel Enildo Broetto , dos Santos Roger Lyrio , Rouver Wender N. , Mill Jose Geraldo 
Published: June 2020

AbstractDiminazene aceturate (DIZE) has been described as an angiotensin‐converting enzyme 2 (ACE2) activator. We aimed to investigate DIZE effects on blood pressure (BP) of spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats. BP was recorded in awake and unrestrained rats 24 hours after femoral artery catheterization. DIZE (15 mg/kg, s.c.) produced a fast BP decrease only in SHR (P < .01). Pre‐treatment with L‐NAME (10 mg/kg, iv) did not change the hypotensive effect on systolic BP whereas mitigated the DIZE effect on diastolic BP (∆ Emax: −31 ± 5 DIZE vs −15 ± 1 mm Hg DIZE + L‐NAME, P < .05). BP changes after DIZE remained unchanged after the treatment of rats with A‐779 (50 ug/kg, iv), a Mas receptor blocker. Vasodilatation curves to DIZE (10‐9 to 10‐4 mol/L) in mesenteric arteries confirmed the NO‐mediation on DIZE effects in SHR, as L‐NAME (300 μmol/L) reduced the vascular sensitivity (∆EC50: −5.12 ± 0.09 CONTROL vs −4.66 ± 0.08 L‐NAME, P < .05) and the magnitude of DIZE effect (area under the curve (AUC), 357.5 ± 8.2 DIZE vs 424.7 ± 11.6 L‐NAME; P < .001), whereas A‐779 (1 μmol/L) enhanced DIZE response (AUC, 357.5 ± 8.2 DIZE vs 309.8 ± 14.7 A‐779, P < .05). Our findings indicate that DIZE acutely reduces the BP in SHR possibly by a mechanism other than Mas receptor activation. This effect seems to be mediated, at least partially, by NO.
Survival motor neuron protein protects H9c2 cardiomyocytes from hypoxia‐induced cell injury by reducing apoptosis
Authors: Zhong Xiao , Song Ziguang , Song Xiang 
Published: June 2020

AbstractBackgroundHypoxia induces cell injury in cardiomyocytes and leads to the development of cardiovascular diseases. The survival motor neuron protein (SMN) is a crucial ubiquitous protein whose functional deficiency causes motor neuron loss seen in spinal muscular atrophy. SMN has shown protective effects on the cardiovascular system and the aim of the present study was to investigate the cardioprotective effects of SMN on hypoxia‐induced cell injury.MethodsCobalt chloride (CoCl2) was used to induce chemical hypoxia in H9c2 cardiomyocytes. Cell proliferation was determined by the MTT assay and the mRNA levels of SMN were evaluated by real‐time polymerase chain reaction. The protein expression levels of SMN, hypoxia‐inducible transcription factor 1α (HIF‐1α), and apoptosis‐related proteins, such as cytochrome c (Cyt c), B cell lymphoma‐2 (Bcl‐2), Bcl‐2 associated X protein (Bax), and cleaved caspase‐3 were evaluated by western blot analysis. Cell apoptosis was analysed using annexin V/propidium iodide (PI) staining.ResultsTreatment with CoCl2 significantly reduced H9c2 cell viability; the level of HIF‐1α, which is a hypoxia‐related indicator increased whereas the expression of SMN protein decreased. Hypoxia also induced cardiomyocyte apoptosis, indicated by reduced Bcl‐2 expression and elevated cleaved caspase‐3, Bax, and cytochrome c levels. Interestingly, SMN, which is a neuron protection factor, ameliorated CoCl2‐induced cell damage by reducing cardiomyocyte apoptosis through upregulation of Bcl‐2 and inhibition of cytochrome c, cleaved caspase‐3, and Bax expression.ConclusionSurvival motor neuron prevents hypoxia‐induced cell apoptosis through inhibition of the mitochondrial apoptotic pathway, and thereby exerts a protective effect on H9c2 cardiomyocytes.
Foucault's Scholarly Virtues and Sexuality Historiography
Authors: MOORE ALISON DOWNHAM 
Published: June 2020

AbstractThis article looks at why many historians of sexuality appear dissatisfied with the level of theoretical precision in the field by considering the reception of Foucault's approach and why some parts of it have been more difficult to assimilate within the historical discipline than others. It proposes that Foucault has been only partially understood by most historians of sexuality, with the result that the properties of his unique disciplined ascesis have been under‐considered. The article argues that Foucault shared many of the critical and ethical goals that are inherent to certain types of historical writing, noting where he diverged from them in ways that have problematised his reception among sexuality historians. It argues that Foucault's own ascesis or ‘transformation of self’ as an intellectual might be better appreciated as a unique set of scholarly virtues expressed in his concerns about teleology, presentism, and the critical practice of ‘history of the present’ that characterise his work on sexuality.
Development of a Pencil Drawn Paper‐based Analytical Device to Detect Lysergic Acid Diethylamide (LSD)*†
Authors: Ribeiro Maria Fernanda M. , Bento Fátima , Ipólito Antônio J. , de Oliveira Marcelo F. 
Published: June 2020

AbstractThe need for agile and proper identification of drugs of abuse has encouraged the scientific community to improve and to develop new methodologies. The drug lysergic acid diethylamide (LSD) is still widely used due to its hallucinogenic effects. The use of voltammetric methods to analyze narcotics has increased in recent years, and the possibility of miniaturizing the electrochemical equipment allows these methods to be applied outside the laboratory; for example, in crime scenes. In addition to portability, the search for affordable and sustainable materials for use in electroanalytical research has grown in recent decades. In this context, employing paper substrate, graphite pencil, and silver paint to construct paper‐based electrodes is a great alternative. Here, a paper‐based device comprising three electrodes was drawn on 300 g/m2 watercolor paper with 8B pencils, and its efficiency was compared to the efficiency of a commercially available screen‐printed carbon electrode. Square wave voltammetry was used for LSD analysis in aqueous medium containing 0.05 mol/L LiClO4. The limits of detection and quantification were 0.38 and 1.27 μmol/L, respectively. Both electrodes exhibited a similar voltammetric response, which was also confirmed during analysis of a seized LSD sample, with recovery of less than 10%. The seized samples were previously analyzed by GCMS technique, employing the full scan spectra against the software spectral library. The electrode selectivity was also tested against 3,4‐methylenedioxymethamphetamine (MDMA) and methamphetamine. It was possible to differentiate these compounds from LSD, indicating that the developed paper‐based device has potential application in forensic chemistry analyses.
Association of bioimpedance‐derived 50‐kHz phase angle as marker of body composition with electrical parameters regarding the Cole‐Cole model
Authors: Yashiro Masatomo , Kotera Hirohisa 
Published: June 2020

AbstractOur aim is to clarify the association of the bioelectrical impedance‐derived 50‐kHz phase angle (φ50) with electrical parameters regarding the Cole‐Cole model and clinical parameters. A total of 440 sets of bioelectrical impedance data from pre‐ and post‐hemodialysis from 157 patients were used. Resistance at infinite frequency (Rinf), resistance at 0 frequency (R0), capacitance of the cell membrane (Cm), and a parameter for the distribution of the time constant (α) were examined as electrical parameters. Normally hydrated lean tissue mass as a percentage of the dry weight (PNHLT), excess fluid mass as a percentage of the dry weight (PExF), body mass index (BMI), age, and sex (Nsex, 0 for male, 1 for female) were examined as clinical parameters. φ50 increased with the decrease in Rinf/R0 and α and also with the increase in Cm (multiple regression coefficients [β]: pre/post, −0.886/−0.936, −0.175/−0.212, and 0.167/0.141), which determined the ratio of intra‐ to extracellular fluid volume (ICV/ECV), tissue homogeneity, and total cell mass. φ50 increased with an increase in PNHLT and BMI and decrease in PExF, Nsex, and age (β: pre/post, 0.654/0.581, 0.466/0.412, −0.483/−0.473, −0.216/−0.154, and −0.145/−0.127). The concordance correlation coefficient between φ50 for pre‐ and post‐hemodialysis (ρ = 0.772) may be improved (ρ = 0.950) by adding a multiplication of 0.2 and PExF to φ50 for correction. φ50 may be used to estimate body composition through the association with ICV/ECV, tissue homogeneity, and total cell mass. The correction for excess fluid is essential in order to use φ50 as a marker of body composition related to nutrition.
Deletion of Tlr3 reduces acute tolerance to alcohol and alcohol consumption in the intermittent access procedure in male mice
Authors: Blednov Yuri A. , Da Costa Adriana , Mayfield Jody , Harris R. Adron , Messing Robert O. 
Published: June 2020

AbstractPharmacological studies implicate toll‐like receptor 3 (TLR3) signaling in alcohol drinking. We examined the role of TLR3 in behavioral responses to alcohol and GABAergic drugs by studying Tlr3 −/− mice. Because of opposing signaling between TLR3 and MyD88 pathways, we also evaluated Myd88 −/− mice. Ethanol consumption and preference decreased in male but not in female Tlr3 −/− mice during two‐bottle choice every‐other‐day (2BC‐EOD) drinking. There were no genotype differences in either sex during continuous or limited‐access drinking. Null mutations in Tlr3 or Myd88 did not alter conditioned taste aversion to alcohol and had small or no effects on conditioned place preference. The Tlr3 null mutation did not alter acute alcohol withdrawal. Male, but not female, Tlr3 −/− mice took longer than wild‐type littermates to recover from ataxia by ethanol or diazepam and longer to recover from sedative‐hypnotic effects of ethanol or gaboxadol, indicating regulation of GABAergic signaling by TLR3. Acute functional tolerance (AFT) to alcohol‐induced ataxia was decreased in Tlr3 −/− mice but was increased in Myd88 −/− mice. Thus, MyD88 and TLR3 pathways coordinately regulate alcohol consumption and tolerance to intoxicating doses of alcohol and GABAergic drugs. Despite similar alcohol metabolism and similar amounts of total alcohol consumed during 2BC and 2BC‐EOD procedures in C57BL/6J mice, only 2BC‐EOD drinking induced tolerance to alcohol‐induced ataxia. Ataxia recovery was inversely correlated with level of drinking in wild‐type and Tlr3 −/− littermates. Thus, deleting Tlr3 reduces alcohol consumption by reducing AFT to alcohol and not by altering tolerance induced by 2BC‐EOD drinking.
Changes in aqueous and vitreous inflammatory cytokine levels in neovascular age‐related macular degeneration: a systematic review and meta‐analysis
Authors: Minaker Samuel A. , Mason Ryan H. , Lahaie Luna Gabriela , Bapat Priya , Muni Rajeev H. 
Published: June 2020

AbstractInflammatory cytokines are involved in the pathogenesis of neovascular age‐related macular degeneration (nAMD) and have been shown to be useful as diagnostic and predictive biomarkers. Given the heterogeneity of data within the literature, we aimed to quantitatively summarize data related to inflammatory cytokines in nAMD. A systematic search without year limitation was performed up to 13 April 2020. Studies were included if they provided data on aqueous or vitreous cytokine concentrations in patients with nAMD. Data were extracted from 95 studies that encompassed 3105 study eyes with nAMD and 1209 control eyes. Effect sizes were generated as standardized mean differences (SMDs) of cytokine concentrations between patients with nAMD and controls. Among the 4314 eyes in 95 studies, aqueous concentrations (standard mean difference, 95% confidence interval and p‐value) of MCP‐1 (0.43, 0.09 to 0.77 and p = 0.01), MIG (0.63, 0.31 to 0.94 and p = 0.0001), TGF‐β (0.45, 0.07 to 0.82 and p = 0.02) and VEGF (0.64, 0.31 to 0.98 and p = 0.0001) were significantly higher in patients with nAMD compared to healthy controls. No differences, failed sensitivity analyses or insufficient data were found between patients with nAMD and healthy controls for the concentrations of the remaining cytokines and with all vitreous samples. Previous studies had shown conflicting associations with nAMD for all 27 cytokines assessed. Our analysis indicates multiple candidate cytokines other than VEGF that are implicated in nAMD and adds clarity to the previous literature. This will help focus translational research in nAMD investigating biomarkers and therapeutic targets.
Geometry of the ideal free distribution: individual behavioural variation and annual reproductive success in aggregations of a social ungulate
Authors: Bonar Maegwin , Lewis Keith P. , Webber Quinn M. R. , Dobbin Maria , Laforge Michel P. , Vander Wal Eric 
Published: June 2020

AbstractVariation in social environment can mitigate risks and rewards associated with occupying a particular patch. We aim to integrate Ideal Free Distribution (IFD) and Geometry of the Selfish Herd (GSH) to address an apparent conflict in their predictions of equal mean fitness between patches (IFD) and declining fitness benefits within a patch (GSH). We tested these hypotheses in a socio‐spatial context using individual caribou that were aggregated or disaggregated during calving and varied in their annual reproductive success (ARS). We then tested individual consistency of these spatial tactics. We reveal that two socio‐spatial tactics accorded similar mean ARS (IFD); however, ARS for aggregated individuals declined near the periphery (GSH). Individuals near the aggregation periphery exhibited flexibility, whereas others were consistent. The integration of classical theories through a contemporary lens of consistent individual differences provides evidence for an integrated GSH and IFD strategy that may represent an evolutionary stable state.