bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recognition of the Trachypetidae stat.n. as a new extant family of Ichneumonoidea (Hymenoptera), based on molecular and morphological evidence
Authors: Quicke Donald L. J. , Austin Andrew D. , Fagan‐Jeffries Erinn P. , Hebert Paul D.N. , Butcher Buntika A. 
Published: February 2020

AbstractThe Trachypetinae (type genus Trachypetus Guérin de Méneville) comprise seven species of large‐bodied wasps in three genera (Cercobarcon Tobias, Megalohelcon Turner and Trachypetus) endemic to continental Australia. Historically they have been variously treated, as members of the Helconinae in the case of Megalohelcon, or as separate subfamilies (Cercobarconinae and Trachypetinae). Some 25 years ago they were united in a single subfamily, the Trachypetinae, based on a number of characters. Although there has been conflicting evidence from morphological and molecular phylogenetic studies as to how best to treat the group, there has been a growing consensus that they fall outside the rest of the Braconidae, although taxon sampling has been a limiting factor for molecular studies. We generated a molecular dataset comprising five gene fragments (nuclear 28S ribosomal rDNA, nuclear 18S, elongation factor 1‐alpha, mitochondrial 16S rDNA, and mitochondrial cytochrome oxidase subunit 1) for a taxonomically broad range of Braconidae, Ichneumonidae, trachypetines and outgroup hymenopterans including the first molecular data for the trachypetines Cercobarcon and Trachypetus obtained using specially designed internal primers. Molecular and combined molecular and morphological analyses confirm the monophyly of the Trachypetinae and robustly place them as sister to the Braconidae. Detailed morphological analysis including newly recognized characters shows that trachypetines lack several synapomorphies that define the Braconidae, and that they possess a number of symplesiomorphies absent from this family but found in some ichneumonids. We conclude that family‐level status is warranted for the group based on both molecular and morphological criteria, and hence we propose the new family, Trachypetidae Schulz stat.n. (type genus Trachypetus Guérin de Méneville), for it. As a result, the remaining extant Braconidae become clearly defined based on synapomorphies not present in Trachypetidae stat.n.This published work has been registered on ZooBank,
http://zoobank.org/urn:lsid:urn:lsid:zoobank.org:pub:5418F709‐D724‐4F14‐89D8‐1E054D1D27D0.
Functional analysis of phospholipase Dδ family in tobacco pollen tubes
Authors: Pejchar Přemysl , Sekereš Juraj , Novotný Ondřej , Žárský Viktor , Potocký Martin 
Published: February 2020

SummaryPhosphatidic acid (PA), an important signalling and metabolic phospholipid, is predominantly localized in the subapical plasma membrane (PM) of growing pollen tubes. PA can be produced from structural phospholipids by phospholipase D (PLD), but the isoforms responsible for production of PM PA were not identified yet and their functional roles remain unknown. Following genome‐wide bioinformatic analysis of the PLD family in tobacco, we focused on the pollen‐overrepresented PLDδ class. Combining live‐cell imaging, gene overexpression, lipid‐binding and structural bioinformatics, we characterized five NtPLDδ isoforms. Distinct PLDδ isoforms preferentially localize to the cytoplasm or subapical PM. Using fluorescence recovery after photobleaching, domain deletion and swapping analyses we show that membrane‐bound PLDδs are tightly bound to PM, primarily via the central catalytic domain. Overexpression analyses suggested isoform PLDδ3 as the most important member of the PLDδ subfamily active in pollen tubes. Moreover, only PLDδ3 shows significant constitutive PLD activity in vivo and, in turn, PA promotes binding of PLDδ3 to the PM. This forms a positive feedback loop leading to PA accumulation and the formation of massive PM invaginations. Tightly controlled production of PA generated by PLDδ3 at the PM is important for maintaining the balance between various membrane trafficking processes that are crucial for plant cell tip growth.
Practice recommendations for the use of sedation in routine hospital-based colonoscopy
Authors: Dossa Fahima , Dubé Catherine , Tinmouth Jill , Sorvari Anne , Rabeneck Linda , McCurdy Bronwen R , Dominitz Jason A , Baxter Nancy N 
Published: February 2020

ObjectiveAlthough sedation improves patient experience during colonoscopy, there is great jurisdictional variability in sedative practices. The objective of this study was to develop practice recommendations for the use of moderate and deep sedation in routine hospital-based colonoscopy to facilitate standardisation of practice.DesignWe recruited 32 multidisciplinary panellists to participate in a modified Delphi process to establish consensus-based recommendations for the use of sedation in colonoscopy. Panel members participated in a values assessment survey followed by two rounds of anonymous online voting on preliminary practice recommendations. An inperson meeting was held between voting rounds to facilitate consensus-building. Consensus was defined as >60% agreement/disagreement with recommendation statements; >80% agreement/disagreement was considered indicative of strong consensus.ResultsTwenty-nine panellists participated in the values assessment survey. Panellists ranked all factors presented as important to the development of practice recommendations. The factor considered most important was patient safety. Patient satisfaction, procedural efficiency, and cost were considered less important. Strong consensus was achieved for all nine practice recommendations presented to the panel. These recommendations included that all endoscopists be able to perform colonoscopy with moderate sedation, that an endoscopist and a single trained nurse are sufficient for performing colonoscopy with moderate sedation, and that anaesthesia-provided deep sedation be used for select patients.ConclusionThe recommendations presented in this study were agreed on by a multidisciplinary group and provide guidance for the use of sedation in routine hospital-based colonoscopy. Standardised sedation practices will promote safe, effective, and efficient colonoscopy for all patients.
Randomised controlled trial to investigate the relationship between mild hypercapnia and cerebral oxygen saturation in patients undergoing major surgery
Authors: Wong Clarence , Churilov Leonid , Cowie Dean , Tan Chong Oon , Hu Raymond , Tremewen David , Pearce Brett , Pillai Param , Karalapillai Dharshi , Bellomo Rinaldo , Weinberg Laurence 
Published: February 2020

ObjectivesThe effects of hypercapnia on regional cerebral oxygen saturation (rSO2) during surgery are unclear. We conducted a randomised controlled trial to investigate the relationship between mild hypercapnia and rSO2. We hypothesised that, compared with targeted normocapnia (TN), targeted mild hypercapnia (TMH) during major surgery would increase rSO2.DesignA prospective, randomised, controlled trial in adult participants undergoing elective major surgery.SettingA single tertiary centre in Heidelberg, Victoria, Australia.Participants40 participants were randomised to either a TMH or TN group (20 to each).InterventionsTMH (partial pressure of carbon dioxide in arterial blood, PaCO2, 45–55 mm Hg) or TN (PaCO235–40 mm Hg) was delivered via controlled ventilation throughout surgery.Primary and secondary outcome measuresThe primary endpoint was the absolute difference between the two groups in percentage change in rSO2from baseline to completion of surgery. Secondary endpoints included intraoperative pH, bicarbonate concentration, base excess, serum potassium concentration, incidence of postoperative delirium and length of stay (LOS) in hospital.ResultsThe absolute difference between the two groups in percentage change in rSO2from the baseline to the completion of surgery was 19.0% higher in both hemispheres with TMH (p<0.001). On both sides, the percentage change in rSO2was greater in the TMH group than the TN group throughout the duration of surgery. The difference between the groups became more noticeable over time. Furthermore, postoperative delirium was higher in the TN group (risk difference 0.3, 95% CI 0.1 to 0.5, p=0.02). LOS was similar between groups (5 days vs 5 days; p=0.99).ConclusionTMH was associated with a stable increase in rSO2from the baseline, while TN was associated with a decrease in rSO2in both hemispheres in patients undergoing major surgery. This resulted in a clear separation of percentage change in rSO2from the baseline between TMH and TN over time. Our findings provide the rationale for larger studies on TMH during surgery.Trial registration numberThe Australian New Zealand Clinical Trials Registry (ACTRN12616000320459).
Post-traumatic stress reactions and doctor-certified sick leave after a workplace terrorist attack: Norwegian cohort study
Authors: Dale Maria Teresa Grønning , Nissen Alexander , Berthelsen Mona , Heir Trond 
Published: February 2020

ObjectiveTo explore the association between the psychosocial work environment and the risk of sick leave among governmental employees with symptom-defined post-traumatic stress disorder (PTSD) after a workplace bomb attack.DesignA prospective study on employees who met the symptom criteria for PTSD. Questionnaire data on the psychosocial work environment 10 months after the terrorist attack was linked to registry data on doctor-certified sick leave in the period 12–22 months after the attack.SettingThe bombing of the government ministries in Oslo, Norway, 22 July 2011.ParticipantsThe study sample consists of 94 Norwegian governmental employees, all with symptom-defined PTSD from the Norwegian version of the PTSD checklist (Post-traumatic Stress Disorder Checklist-Specific) measured 10 months after the attack.ResultsAfter adjustment for sex and severity of PTSD symptoms, predictability at work reduced the odds of sick leave (adjusted OR=0.62, 95% CI 0.40 to 0.98). Sense of control over decisions at work was associated with fewer absence days for employees with sick leave (adjusted rate ratio=0.61, 95% CI 0.38 to 0.98).ConclusionsEmployees with PTSD after workplace terrorism would benefit from control over their workplace conditions and increased predictability to reduce the risk of sick leave. The findings suggest that the work environment can facilitate employees’ work ability after stressful events, independent of severity of PTSD symptoms.
Effectiveness of a culturally adapted biopsychosocial intervention (POHON SIHAT) in improving self-efficacy in patients with diabetes attending primary healthcare clinics in Putrajaya, Malaysia: study protocol of a randomised controlled trial
Authors: Suhaimi Aida Farhana , Ibrahim Normala , Tan Kit-Aun , Silim Umi Adzlin , Moore Gaye , Ryan Brigid , Castle David J 
Published: February 2020

IntroductionPeople with diabetes are often associated with multifaceted factors and comorbidities. Diabetes management frameworks need to integrate a biopsychosocial, patient-centred approach. Despite increasing efforts in promotion and diabetes education, interventions integrating both physical and mental health components are still lacking in Malaysia. The Optimal Health Programme (OHP) offers an innovative biopsychosocial framework to promote overall well-being and self-efficacy, going beyond education alone and has been identified as relevant within the primary care system. Following a comprehensive cultural adaptation process, Malaysia’s first OHP was developed under the name ‘Pohon Sihat’ (OHP). The study aims to evaluate the effectiveness of the mental health-based self-management and wellness programme in improving self-efficacy and well-being in primary care patients with diabetes mellitus.Methods and analysisThis biopsychosocial intervention randomised controlled trial will engage patients (n=156) diagnosed with type 2 diabetes mellitus (T2DM) from four primary healthcare clinics in Putrajaya. Participants will be randomised to either OHP plus treatment as usual. The 2-hour weekly sessions over five consecutive weeks, and 2-hour booster session post 3 months will be facilitated by trained mental health practitioners and diabetes educators. Primary outcomes will include self-efficacy measures, while secondary outcomes will include well-being, anxiety, depression, self-care behaviours and haemoglobin A1c glucose test. Outcome measures will be assessed at baseline, immediately postintervention, as well as at 3 months and 6 months postintervention. Where appropriate, intention-to-treat analyses will be performed.Ethics and disseminationThis study has ethics approval from the Medical Research and Ethics Committee, Ministry of Health Malaysia (NMRR-17-3426-38212). Study findings will be shared with the Ministry of Health Malaysia and participating healthcare clinics. Outcomes will also be shared through publication, conference presentations and publication in a peer-reviewed journal.Trial registration numberNCT03601884.
Left ventricular filling pressure and survival following aortic valve replacement for severe aortic stenosis
Authors: Thaden Jeremy J , Balakrishnan Mahesh , Sanchez Jose , Adigun Rosalyn , Nkomo Vuyisile T , Eleid Mackram , Dahl Jordi , Scott Christopher , Pislaru Sorin , Oh Jae K , Schaff Hartzell , Pellikka Patricia A 
Published: February 2020

ObjectiveTo determine whether echocardiography-derived left ventricular filling pressure influences survival in patients with severe aortic stenosis (AS) undergoing aortic valve replacement (AVR).MethodsWe retrospectively reviewed 1383 consecutive patients with severe AS, normal ejection fraction and interpretable filling pressure undergoing AVR. Left ventricular filling pressure was determined according to current guidelines using mitral inflow, mitral annular tissue Doppler, estimated right ventricular systolic pressure and left atrial volume index. Cox proportional hazards regression was used to assess the influence of various parameters on mortality.ResultsAge was 75±10 years and 552 (40%) were female. Left ventricular filling pressure was normal in 325 (23%), indeterminate in 463 (33%) and increased in 595 (43%). Mean follow-up was 7.3±3.7 years, and mortality was 1.2%, 4.2% and 18.9% at 30 days and 1 and 5 years, respectively. Compared with patients with normal filling pressure, patients with increased filling pressure were older (78±9 vs 70±12, p<0.001), more often female (45% vs 35%, p=0.002) and were more likely to have New York Heart Association class III–IV symptoms (35% vs 24%, p=0.004), coronary artery disease (55% vs 42%, p<0.001) and concentric left ventricular hypertrophy (63% vs 37%, p<0.001). After correction for other factors, increased left ventricular filling pressure remained an independent predictor of mortality after successful AVR (adjusted HR 1.45 (95% CI 1.16 to 1.81), p=0.005).ConclusionsPreoperative increased left ventricular filling pressure is common in patients with AS undergoing AVR and has important prognostic implications, regardless of symptom status. Future prospective studies should consider whether patients with increased filling pressure would benefit from earlier operation.
Thoracoscopic lung biopsy under regional anesthesia for interstitial lung disease
Authors: Kurihara Chitaru , Tolly Brian , DeWolf Andre , Nader Antoun , Kim Samuel , Odell David D , Argento Angela C , Budinger G R Scott , Bharat Ankit 
Published: February 2020

BackgroundInterstitial lung disease (ILD) management guidelines support lung biopsy-guided therapy. However, the high mortality associated with thoracoscopic lung biopsy using general anesthesia (GA) in patients with ILD has deterred physicians from offering this procedure and adopt a diagnostic approach based on high-resolution CT. Here we report that thoracoscopy under regional anesthesia could be a safer alternative for lung biopsy and effectively guide ILD treatment.MethodsThis was a single-center retrospective review of prospectively maintained database and consisted of patients who underwent thoracoscopic lung biopsy between March 2016 and March 2018. Patients were divided into two groups: (A) GA, and (B) regional anesthesia using monitored anesthesia care (MAC) and thoracic epidural anesthesia (TEA).ResultsDuring the study period, 44 patients underwent thoracoscopic lung biopsy. Of these, 15 underwent MAC/TEA. There were no significant differences between the two groups with regard to pulmonary function test and clinicodemographic profile. However, operative time and hospital stay were shorter in MAC/TEA group (32.5±18.5 min vs 50.8±18.4; p=0.004, 1.0±1.3 days vs 10.0±34.7 days; p<0.001, respectively). Eight patients in the GA group, but none in the MAC/TEA group, experienced worsening of ILD after lung biopsy (p=0.03). Additionally, one patient in the GA group died due to acute ILD worsening. No cases of MAC/TEA group had to be converted to GA. In all cases a pathological diagnosis could be made.ConclusionsThoracoscopy using regional anesthesia might be a safer alternative to lung biopsy in patients with ILD.
Quasi-periodic oscillations around Kerr-MOG black holes
Authors: Kološ Martin , Shahzadi Misbah , Stuchlík Zdeněk 
Published: February 2020

AbstractThe study of the quasi-periodic oscillations (QPOs) of X-ray flux observed in the stellar-mass black hole (BH) binaries can provide a powerful tool for testing the phenomena occurring in strong gravity regime. We thus present and apply to three known microquasars the model of epicyclic oscillations of Keplerian discs orbiting rotating BHs governed by the modified theory of gravity (MOG). We show that the standard geodesic models of QPOs can explain the observationally fixed data from the three microquasars, GRO 1655-40, XTE 1550-564, and GRS 1915+105. We perform a successful fitting of the high frequency (HF) QPOs observed in these microquasars, under assumption of MOG BHs, for epicyclic resonance and its variants, relativistic precession and its variants, tidal disruption, as well as warped disc models and discuss the corresponding constraints of parameters of the model, which are the mass and spin and parameter $$\alpha $$α of the BH.
Automatic Seizure Detection using Fully Convolutional Nested LSTM
Authors: Li Yang , Yu Zuyi , Chen Yang , Yang Chunfeng , Li Yue , Allen Li X. , Li Baosheng 
Published: February 2020

The automatic seizure detection system can effectively help doctors to monitor and diagnose epilepsy thus reducing their workload. Many outstanding studies have given good results in the two-class seizure detection problems, but most of them are based on hand-wrought feature extraction. This study proposes an end-to-end automatic seizure detection system based on deep learning, which does not require heavy preprocessing on the EEG data or feature engineering. The fully convolutional network with three convolution blocks is first used to learn the expressive seizure characteristics from EEG data. Then these robust EEG features pertinent to seizures are presented as an input to the Nested Long Short-Term Memory (NLSTM) model to explore the inherent temporal dependencies in EEG signals. Lastly, the high-level features obtained from the NLSTM model are fed into the softmax layer to output predicted labels. The proposed method yields an accuracy range of 98.44–100% in 10 different experiments based on the Bonn University database. A larger EEG database is then used to evaluate the performance of the proposed method in real-life situations. The average sensitivity of 97.47%, specificity of 96.17%, and false detection rate of 0.487 per hour are yielded. For CHB–MIT Scalp EEG database, the proposed model also achieves a segment-level sensitivity of 94.07% with a false detection rate of 0.66 per hour. The excellent results obtained on three different EEG databases demonstrate that the proposed method has good robustness and generalization power under ideal and real-life conditions.
Radial anharmonic oscillator: Perturbation theory, new semiclassical expansion, approximating eigenfunctions. II. Quartic and sextic anharmonicity cases
Authors: del Valle J. C. , Turbiner A. V. 
Published: February 2020

In our previous paper I (del Valle–Turbiner, 2019) a formalism was developed to study the general [Formula: see text]-dimensional radial anharmonic oscillator with potential [Formula: see text]. It was based on the Perturbation Theory (PT) in powers of [Formula: see text] (weak coupling regime) and in inverse, fractional powers of [Formula: see text] (strong coupling regime) in both [Formula: see text]-space and in [Formula: see text]-space, respectively. As a result, the Approximant was introduced — a locally-accurate uniform compact approximation of a wave function. If taken as a trial function in variational calculations, it has led to variational energies of unprecedented accuracy for cubic anharmonic oscillator. In this paper, the formalism is applied to both quartic and sextic, spherically-symmetric radial anharmonic oscillators with two term potentials [Formula: see text], [Formula: see text], respectively. It is shown that a two-parametric Approximant for quartic oscillator and a five-parametric one for sextic oscillator for the first four eigenstates used to calculate the variational energy are accurate in 8–12 figures for any [Formula: see text] and [Formula: see text], while the relative deviation of the Approximant from the exact eigenfunction is less than [Formula: see text] for any [Formula: see text].
Vacuum polarization of generalized quantum electrodynamics in the Heisenberg picture
Authors: Montenegro David 
Published: February 2020

In this work, we consider the generalized quantum electrodynamics proposed by Podolsky in Heisenberg picture via Källén methodology. We investigate the effects of higher-order derivatives to understand the qualitative and quantitative aspects of vacuum polarization. In addition, the most general structure of induced current and polarization tensor that emerge naturally by a perturbative scheme “à la” Källén is also obtained. Afterward, we discuss the physical implication of charge renormalization in the perspective of unitary and stable Podolsky theory.
Targeted Brain Tumor Radiotherapy Using an Auger Emitter
Authors: Pirovano Giacomo , Jannetti Stephen A. , Carter Lukas M. , Sadique Ahmad , Kossatz Susanne , Guru Navjot , Demétrio De Souza França Paula , Maeda Masatomo , Zeglis Brian M. , Lewis Jason S. , Humm John L. , Reiner Thomas 
Published: February 2020

Abstract

Purpose:
Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly limit survival, with scant progress having been made in recent decades.

Experimental Design:
123I-MAPi (Iodine-123 Meitner-Auger PARP1 inhibitor) is a precise therapeutic tool composed of a PARP1 inhibitor radiolabeled with an Auger- and gamma-emitting iodine isotope. Here, the PARP inhibitor, which binds to the DNA repair enzyme PARP1, specifically targets cancer cells, sparing healthy tissue, and carries a radioactive payload within reach of the cancer cells' DNA.

Results:
The high relative biological efficacy of Auger electrons within their short range of action is leveraged to inflict DNA damage and cell death with high precision. The gamma ray emission of 123I-MAPi allows for the imaging of tumor progression and therapy response, and for patient dosimetry calculation. Here we demonstrated the efficacy and specificity of this small-molecule radiotheranostic in a complex preclinical model. In vitro and in vivo studies demonstrate high tumor uptake and a prolonged survival in mice treated with 123I-MAPi when compared with vehicle controls. Different methods of drug delivery were investigated to develop this technology for clinical applications, including convection enhanced delivery and intrathecal injection.

Conclusions:
Taken together, these results represent the first full characterization of an Auger-emitting PARP inhibitor which demonstrate a survival benefit in mouse models of GBM and confirm the high potential of 123I-MAPi for clinical translation.