bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the shear bond strength of resin cement to enamel after bleaching with Er: YAG and diode laser
Authors: Ceyda Akin , Müjde Sevimay , Yusuf Ozyilmaz Ozgun , Neslihan Cokuk 
Published: May 2020

Objective: The shear bond strength (SBS) of composite resin cement and color change to enamel bleached with two different concentrations of hydrogen peroxide (HP) bleaching agents in combination with two different laser applications was evaluated. Materials and Methods: The Er: YAG laser ( λ = 2940 nm) and diode laser ( λ = 940 nm) were used with the bleaching agent consisting of 40% HP opalescence (Opalescence Xtra Boost, Ulgen, South Jordan, UT, USA) and 35% HP whiteness (Whiteness HP Blue, FGM Dental Products, Joinville, SC, Brazil). Seventy-two human extracted teeth were randomly divided into two groups: For the 40% HP treatment, 36 specimens were divided into three subgroups: (1) HP agent with no laser treatment, (2) HP agent treated with Er: YAG laser, and (3) HP agent treated with diode laser. The same protocol was performed for the 35% HP. The color change was analyzed using the Commission Internationale de l’ Eclairage (CIE) L* a* b* system and surface roughness was analyzed by an atomic force microscope. The specimens were bonded with resin cement and a shear bond test was performed at 0.5 mm/min. The failure surfaces were evaluated using scanning electron microscope analysis. Results: Δ E value of the 40% HP + Er: YAG group was significantly higher than the other groups while diode groups showed the lower SBS values than the control groups ( p < 0.05). Conclusions: The Er: YAG laser with 40% HP may be effective for the brighter teeth and the use of Er: YAG laser produced higher adhesion between enamel and resin cement than diode laser.
Surgical adhesions among women undergoing laparoscopic gynecological surgery with or without adhesiolysis – prevalence, severity, and implications: retrospective cohort study at a University Hospital
Authors: Al-Husban Naser , Elayyan Yousef , El-Qudah Malab , Aloran Bayan , Batayneh Rima 
Published: May 2020

Objective: To find out the prevalence of adhesions, severity, and their relation to the current clinical scenario and to the type of previous surgery. Methods and Materials: A retrospective study of patients who already had different previous abdominopelvic surgery and subsequently underwent gynecological laparoscopic surgery for various indications. The patients’ clinical and operative notes were reviewed and analyzed. Results: There were 654 procedures performed. The most common indication for the laparoscopic surgery was secondary infertility 23.5%, followed by adnexal lesions 22.0% and primary infertility 19.6%. Intraoperative adhesions were found in 45.3%. Adhesions were deemed relevant to the clinical scenario in 21.3%. Patients who had a previous history of open (traditional) surgery were more likely to be found with adhesions in comparison with patients with history of laparoscopic surgery (odds ratio: 2.7, 95% confidence interval: 1.4–5.3, p = 0.0025). The presence of adhesions was found to be strongly associated with previous abdominopelvic surgery than non-abdominopelvic surgery (odds ratio: 4.3, p = 0.0078, 95% confidence interval: 1.5–12.5). The most common location of the adhesions was abdominal (36.1%), mixed abdominal and pelvic (35.1%), and pelvic adhesions (28.1%). Severe adhesions were found in 36.1%; 13.6% of converted laparoscopy to open surgery was due to adhesions. Cesarean sections were significantly associated with adhesions. Patients who had cesarean sections were more likely to have adhesions than those who had not (odds ratio: 5.7, 95% confidence interval: 3.8–8.6, p < 0.0001). Adhesiolysis was done without complications in 19.6% of patients with adhesions. Conclusion: Adhesions were prevalent in gynecological patients with previous abdominopelvic surgery. They were a significant contributor to the gynecological and reproductive issues. To minimize the risk of postoperative adhesions, laparoscopic approach should be encouraged instead of traditional surgery and rates of cesarean section should be reduced. Further high-quality studies are needed to establish conclusion and practical guidance toward the use of adhesion barriers.
Inflammatory signaling in dengue-infected platelets requires translation and secretion of nonstructural protein 1
Authors: Quirino-Teixeira Anna Cecíllia , Rozini Stephane Vicente , Barbosa-Lima Giselle , Coelho Diego Rodrigues , Carneiro Pedro Henrique , Mohana-Borges Ronaldo , Bozza Patrícia T. , Hottz Eugenio D. 
Published: May 2020

Abstract
Emerging evidence identifies major contributions of platelets to inflammatory amplification in dengue, but the mechanisms of infection-driven platelet activation are not completely understood. Dengue virus nonstructural protein-1 (DENV NS1) is a viral protein secreted by infected cells with recognized roles in dengue pathogenesis, but it remains unknown whether NS1 contributes to the inflammatory phenotype of infected platelets. This study shows that recombinant DENV NS1 activated platelets toward an inflammatory phenotype that partially reproduced DENV infection. NS1 stimulation induced translocation of α-granules and release of stored factors, but not of newly synthesized interleukin-1β (IL-1β). Even though both NS1 and DENV were able to induce pro-IL-1β synthesis, only DENV infection triggered caspase-1 activation and IL-1β release by platelets. A more complete thromboinflammatory phenotype was achieved by synergistic activation of NS1 with classic platelet agonists, enhancing α-granule translocation and inducing thromboxane A2 synthesis (thrombin and platelet-activating factor), or activating caspase-1 for IL-1β processing and secretion (adenosine triphosphate). Also, platelet activation by NS1 partially depended on toll-like receptor-4 (TLR-4), but not TLR-2/6. Finally, the platelets sustained viral genome translation and replication, but did not support the release of viral progeny to the extracellular milieu, characterizing an abortive viral infection. Although DENV infection was not productive, translation of the DENV genome led to NS1 expression and release by platelets, contributing to the activation of infected platelets through an autocrine loop. These data reveal distinct, new mechanisms for platelet activation in dengue, involving DENV genome translation and NS1-induced platelet activation via platelet TLR4.
Adult T-cell leukemia/lymphoma incidence rate in French Guiana: a prospective cohort of women infected with HTLV-1
Authors: Ramassamy Jill-Léa , Tortevoye Patricia , Ntab Balthazar , Seve Béatrice , Carles Gabriel , Gaquière Dominique , Madec Yoann , Fontanet Arnaud , Gessain Antoine 
Published: May 2020

Abstract
Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy caused by the human T-cell leukemia virus type 1 (HTLV-1). The incidence of ATL among HTLV-1 carriers remains largely unknown in endemic countries other than Japan as very few prospective studies have been performed. We assessed the ATL incidence rate among HTLV-1 infected women in a prospective cohort in French Guiana. This is the first prospective study to assess the ATL incidence rate in an area of South America where HTLV-1 prevalence is high. Patients were enrolled between 1991 and 2005, and follow-up continued until April 2018. In the general hospital in Saint-Laurent-du-Maroni, 307 pregnant women were diagnosed with HTLV-1 infection, and 268 of them were observed for a median of 16.7 years. During follow-up, 9 ATL incident cases occurred resulting in an ATL incidence rate of 2.03 per 1000 HTLV-1 carrier-years (95% confidence interval, 0.93-3.85 per 1000 HTLV-1 carrier-years). The median age at diagnosis was 47.4 years, and median survival from diagnosis was low at 3.5 months. The ATL incidence rate was elevated for a study population consisting mostly of young people, which could either be a general feature in South America or could be specific to the Noir Marron population that constituted most of the cohort.
Measuring inflammation in paediatric severe asthma: biomarkers in clinical practice
Authors: Licari Amelia , Manti Sara , Castagnoli Riccardo , Leonardi Salvatore , Marseglia Gian Luigi 
Published: May 2020

Severe asthma in children is a highly heterogeneous disorder, encompassing different clinical characteristics (phenotypes) and immunopathological pathways (endotypes). Research is focusing on the identification of noninvasive biomarkers able to predict treatment response and assist in designing personalised therapies for severe asthma. Blood and sputum eosinophils, serum IgE and exhaled nitric oxide fraction mostly reflect type 2 airway inflammation in children. However, in the absence of available point-of-care biomarkers, the diagnosis of non-type 2 asthma is still reached by exclusion. In this review, we present the most recent evidence on biomarkers for severe asthma and discuss their implementation in clinical practice. We address the methods for guiding treatment decisions and patient identification, focusing on the paediatric age group.Key pointsSevere asthma in children is a highly heterogeneous disorder, encompassing different clinical characteristics (phenotypes) and immunopathological pathways (endotypes).Research is focusing on the identification of noninvasive biomarkers able to predict treatment response and assist in designing personalised therapies for severe asthma.Blood and sputum eosinophils, serum IgE and exhaled nitric oxide fraction mostly reflect type 2 airway inflammation in children. However, knowledge regarding non-type 2 inflammation and related biomarkers is still lacking.Educational aimsTo summarise the most recent evidence on biomarkers for severe asthma in children.To discuss their implementation in clinical practice through guiding patient identification and treatment decisions.
Bamboo surface coated with polymethylsilsesquioxane/Cu-containing nanoparticles (PMS/CuNP) xerogel for superhydrophobic and anti-mildew performance
Authors: Wang Da , Hu Chuanshuang , Gu Jin , Tu Dengyun , Wang Ge , Jiang Mingliang , Zhang Weiwei 
Published: May 2020

AbstractIn this study, a colloidal suspension, composed of polymethylsilsesquioxane (PMS) and Cu-containing nanoparticles (CuNP), was prepared through simple neutralization reaction using sodium methyl siliconate (SMS) and CuCl2solutions. The nano-structure of CuNP was investigated by TEM and the results showed that lamellar crystal Cu(OH)2with size of around 10 nm was imbedded in PMS nano-particle. The FTIR also confirmed the presence of small amount of PMS in CuNP. The specific nano-structure of CuNP resulted in excellent thermal stability based on TG analysis. After dip-coating in optimized conditions and drying, a PMS/CuNP xerogel coating layer was generated at the bamboo surface, endowing superhydrophobic and excellent anti-mildew performance according to ASTM D3273-16. The water contact angle (WCA) reached up to 151.3 ± 1.9° and the mildew resistance grade was marked as 10 where no mold was found at the surface after 4 weeks incubation.
Triple-Band Perfect Light Absorber Based on Hybrid Metasurface for Sensing Application
Authors: Cheng Yongzhi , Chen Fu , Luo Hui 
Published: May 2020

AbstractA simple design of triple-band perfect light absorber (PLA) based on hybrid metasurface in visible region has been presented in this work, which turns out to be applicable for refractive index (RI) sensing. Distinct from previous designs, the proposed hybrid metasurface for visible PLA is only consisted of periodic silicon cross nanostructure arrays and gold substrate. The periodic silicon cross arrays deposited on the gold substrate contribute to excite the guided modes under the normal incident light illumination. According to the simulation results, it can be found that three perfect absorption peaks of 98.1%, 98.7%, and 99.6% which are located at 402.5 THz, 429.5 THz, and 471.5 THz, respectively, have been clearly observed in PLA. This triple-band perfect absorption effect could be attributed to the intrinsic loss of silicon material originated from the guided mode excitations caused by the standing waves of different orders. It has been confirmed that the perfect absorption properties of the PLA can be easily regulated by changing the geometric parameters of the unit-cell nanostructure. Furthermore, the designed PLA served as a RI sensor can achieve sensitivity of about 25.3, 41.3, and 31.9 THz /refractive index unit (RIU). It can be believed that the proposed design of PLA for RI sensing would provide great potential applications in sensing, detecting, the enhanced visible spectroscopy, etc.
Numerical investigation of particles’ transport, deposition and resuspension under unsteady conditions in constructed stormwater ponds
Authors: Yan Hexiang , Vosswinkel Nina , Ebbert Simon , Lipeme Kouyi Gislain , Mohn Rainer , Uhl Mathias , Bertrand-Krajewski Jean-Luc 
Published: May 2020

Abstract
Background
Total suspended solids (TSS) loads carried by stormwater runoff is a major pollutant source on receiving water bodies. Stormwater ponds are widely used for controlling TSS discharge. However, the trap efficiency is not satisfactory because it is affected by many complex factors, which are not fully understood. Therefore, there is a necessity to gain insight into the sediment process in stormwater ponds for optimization design of stormwater ponds. To address this issue, we propose a novel modeling framework based on discrete phase model (DPM), aiming to fully represent the sediment transport, settling, and resuspension at grain scale under time-dependent conditions.

Results
In the newly proposed method, heterogeneous characteristics of sediments’ loads, varying flows and sediment loads, settling and resuspension effect at grain scale, time-dependent conditions, and turbulent effect are all well considered. The proposed models have been coded with C language and hooked in computational fluid dynamics software Fluent, and the methods were tested with a case of laboratory experimental setup. Different bed boundary conditions are tested and compared with the observation data for optimization parameters’ identification. The simulation results demonstrated that the physically based DPM with the newly developed method can well reproduce the evolution of sediment transport, settling and resuspension behaviors compared with the scale experiment.

Conclusions
The newly proposed method can accurately predict the trap efficiency and temporal–spatial sediment distribution. The decomposition of bed load motion at grain scale is a necessary and valid way to represent the sedimentation process in shallow ponds. The developed model could be a tool to help us gain insight into the sediment transport phenomena at grain scale in shallow tanks since it can provide detailed information which the experiment cannot.
Carbonaceous composite materials from calcination of azo dye-adsorbed layered double hydroxide with enhanced photocatalytic efficiency for removal of Ibuprofen in water
Authors: Shen Xiaolin , Zhu Zhiliang , Zhang Hua , Di Guanglan , Chen Ting , Qiu Yanling , Yin Daqiang 
Published: May 2020

Abstract
Background
The discard of used adsorbents may pose a great threat to human health and ecological environment. This work herein reported a facile and feasible method, with aims of (i) reusing the calcined layered double hydroxide (CLDH) adsorbent after azo dye adsorption, and (ii) being further used as a photocatalyst to enhance the degradation of typical pharmaceuticals. Calcination under inner gas flow has been utilized to carbonize adsorbed azo dye and a kind of novel carbonaceous CLDH composite material (CM-CLDH) was synthesized. This fabricated material was used as a catalyst for Ibuprofen removal in water samples under simulated sunlight irradiation.

Results
According to our experimental results, combination of carbonaceous material with CLDH showed an enhanced photocatalytic performance compared to original CLDH materials. More than 90% of Ibuprofen could be removed in less than 180 min. Introduction of carbon material narrowed catalyst’s band gap and turned its conduct band potential to a more negative state, which brought considerable light absorption and higher oxidation ability of photo-induced electrons. Furthermore, photoluminescent spectra and transient photocurrent examination confirmed that carbon material suppressed recombination of photo-induced electrons and holes through faster electron transportation. Under experimental conditions, the removal efficiency of Ibuprofen by CM-CLDH composite kept above 90% during five cycles.

Conclusion
Calcination under inner gas flow can transform organic pollutant-adsorbed CLDH to CM-CLDH composite with higher photocatalytic performance. A feasible way to reuse spent LDH adsorbents was proposed, which is a benefit to reduce second pollution of spent adsorbents in environment.
A novel electron transfer flavoprotein dehydrogenase (ETFDH) gene mutation identified in a newborn with glutaric acidemia type II: a case report of a Chinese family
Authors: Ou Mingcai , Zhu Lin , Zhang Yong , Zhang Yaguo , Zhou Jingyao , Zhang Yu , Chen Xuelian , Yang Lijuan , Li Ting , Su Xingyue , Hu Qi , Wang Wenjun 
Published: May 2020

Abstract
Background
Glutaric acidemia type II (GA II) or multiple acyl-CoA dehydrogenase deficiency (MADD, OMIM 231680) is an inherited autosomal recessive disease affecting fatty acid, amino acid and choline metabolism, due to mutations in one of three genes namely, electron transfer flavoprotein alpha-subunit, ETFA, electron transfer flavoprotein β-subunit, ETFB and electron transfer flavoprotein dehydrogenase, ETFDH. Currently, few studies have reported genetic profiling of neonatal-onset GA II. This study aimed to identify the genetic mutations in a Chinese family with GA II.

Case presentation
We reported a case of GA II with purulent meningitis and septicemia and identified a novel ETFDH gene mutation in a female infant. The patient developed an episode of hypoglycemia and hypotonicity on the postnatal first day. Laboratory investigations revealed elevations of multiple acylcarnitines indicating glutaric acidemia type II in newborn screening analysis. Urinary organic acids were evaluated for the confirmation and revealed a high glutaric acid excretion. Genetic analysis revealed two mutations in the ETFDH gene (c.623_626 del / c. 1399G > C), which were considered to be the etiology for the disease. The novel mutation c.623_626 del was identified in the proband infant and her father, her mother was carriers of the mutation c.1399G > C.

Conclusions
A novel variant (c.623_626 del) and a previously reported missense (c.1399G > C) in the ETFDH gene have been identified in the family. The two variants of ETFDH gene identified probably underlie the pathogenesis of Glutaric acidemia type II in this family, and also enlarge ETFDH genotype-phenotype correlations spectrum.
A novel pathogenic frameshift variant unmasked by a large de novo deletion at 13q21.33-q31.1 in a Chinese patient with neuronal ceroid lipofuscinosis type 5
Authors: Li Wei , Fan Xin , Zhang Yue , Huang Limei , Jiang Tingting , Qin Zailong , Su Jiasun , Luo Jingrong , Yi Shang , Zhang Shujie , Shen Yiping 
Published: May 2020

Abstract
Background
Neuronal ceroid lipofuscinosis type 5 (CLN5) is a rare form of neuronal ceroid lipofuscinoses (NCLs) which are a group of inherited neurodegenerative diseases characterized by progressive intellectual and motor deterioration, visual failure, seizures, behavioral changes and premature death. CLN5 was initially named Finnish variant late infantile NCL, it is now known to be present in other ethnic populations and with variable age of onset. Few CLN5 patients had been reported in Chinese population.

Case presentation
In this paper, we report the symptoms of a Chinese patient who suffer from developmental regression and grand mal epilepsy for several years. The DNA was extracted from peripheral blood of proband and both parents, and then whole exome sequencing was performed using genomic DNA. Both sequence variants and copy number variants (CNVs) were analyzed and classified according to guidelines. As the result, a novel frameshift mutation c.718_719delAT/p.Met240fs in CLN5 and a de novo large deletion at 13q21.33-q31.1 which unmasked the frameshift mutation were identified in the proband. Despite the large de novo deletion, which can be classified as a pathogenic copy number variant (CNV), the patient’s clinical presentation is mostly consistent with that of CLN5, except for early developmental delay which is believed due to the large deletion. Both variants were detected simultaneously by exome sequencing.

Conclusions
This is the first report of whole gene deletion in combination with a novel pathogenic sequence variant in a CLN5 patient. The two mutations detected with whole exome sequencing simultaneously proved the advantage of the sequencing technology for genetic diagnostics.
Radiosurgery and fractionated stereotactic body radiotherapy for patients with lung oligometastases
Authors: Kalinauskaite Goda G. , Tinhofer Ingeborg I. , Kufeld Markus M. , Kluge Anne A. , Grün Arne A. , Budach Volker V. , Senger Carolin C. , Stromberger Carmen C. 
Published: May 2020

Abstract
Background
Patients with oligometastatic disease can potentially be cured by using an ablative therapy for all active lesions. Stereotactic body radiotherapy (SBRT) is a non-invasive treatment option that lately proved to be as effective and safe as surgery in treating lung metastases (LM). However, it is not clear which patients benefit most and what are the most suitable fractionation regimens. The aim of this study was to analyze treatment outcomes after single fraction radiosurgery (SFRS) and fractionated SBRT (fSBRT) in patients with lung oligometastases and identify prognostic clinical features for better survival outcomes.

Methods
Fifty-two patients with 94 LM treated with SFRS or fSBRT between 2010 and 2016 were analyzed. The characteristics of primary tumor, LM, treatment, toxicity profiles and outcomes were assessed. Kaplan-Meier and Cox regression analyses were used for estimation of local control (LC), overall survival (OS) and progression-free survival.

Results
Ninety-four LM in 52 patients were treated using SFRS/fSBRT with a median of 2 lesions per patient (range: 1–5). The median planning target volume (PTV)-encompassing dose for SFRS was 24 Gy (range: 17–26) compared to 45 Gy (range: 20–60) in 2–12 fractions with fSBRT. The median follow-up time was 21 months (range: 3–68). LC rates at 1 and 2 years for SFSR vs. fSBRT were 89 and 83% vs. 75 and 59%, respectively (p = 0.026). LM treated with SFSR were significantly smaller (p = 0.001). The 1 and 2-year OS rates for all patients were 84 and 71%, respectively. In univariate analysis treatment with SFRS, an interval of ≥12 months between diagnosis of LM and treatment, non-colorectal cancer histology and BED < 100 Gy were significantly associated with better LC. However, none of these parameters remained significant in the multivariate Cox regression model. OS was significantly better in patients with negative lymph nodes (N0), Karnofsky performance status (KPS) > 70% and time to first metastasis ≥12 months. There was no grade 3 acute or late toxicity.

Conclusions
Longer time to first metastasis, good KPS and N0 predicted better OS. Good LC and low toxicity rates were achieved after short SBRT schedules.