bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Single or Multiple Doses of Grapefruit Juice on the Analgesic Effect of Ibuprofen in Mice
Authors: Za'abi Mohammed Al , Sawaqi Amjad Al , Alawi Khalid Ali Al , Tobi Mohammed Al , Ashique Mohammed , Ali Badreldin H. 
Published: September 2020

Grapefruit juice (GFJ) is a rich source of nutritional compounds but has been shown to alter the concentrations of several clinically useful drugs. Ibuprofen is a commonly used over-the counter-drug.
Aim: This study aims to examine the effect of a single or multiple dose of GFJ on the analgesic effect of ibuprofen.
Methodology: CD1 male mice were randomly distributed into four equal groups (n=9, each). The first group served as a control, the second group was given ibuprofen (100 mg/Kg) by oral gavage, the third group was given a single dose of GFJ (10 mg/Kg) by oral gavage followed by ibuprofen, and the fourth group was given a single dose of GFJ for five days and on the fifth day was given ibuprofen. The analgesic effect was tested using two methods with different mechanisms: thermal (hot plate) and chemical (acetic acid-induced abdominal constriction) pharmacologic stimuli models.
Results: Both GFJ dosing regimen significantly increased the duration of abdominal constriction test when compared with ibuprofen group and did not exert any significant effect on the hot plate effect. This suggest that GFJ may affect the peripherally modulated analgesic effect of ibuprofen. Conclusion: The observed effect of GFJ on ibuprofen analgesic effect warrants further studies on their impact and clinical significance on humans.
Comparative Evaluation of Porcelain Fused to Metal (PFM) Material used for Fixed Partial Prosthesis Placed on Vital & Non-vital Abutments on the Periodontal Status – A Two Year Retrospective Follow-up
Authors: Shetty Shreya , Shetty Karunakar , Wali Othman , Tayeb Raghad , Abdou Jumana , Sheikh Khamrunissa Hussain 
Published: September 2020

Objective: Sound periodontal foundation of abutment teeth is essential for successful restorative therapy and also for long-term success of prosthodontic restorations. Porcelain fused to metal (PFM) has been a popular choice of novel esthetic material in fixed prosthodontics over the last few decades. The present study aimed to assess the long term effect and tissue responses of fixed partial prosthesis using PFM material on vital and non- vital abutments on the periodontal parameters both clinically and radiographically.
Methodology: Following ethical committee approval, the study group comprised of 86 abutment teeth in 41 systemically healthy patients (24 males and 17 females) aged between 18 – 45 years who had received 3 unit fixed prosthesis made of PFM, having equigingival margins using vital and non-vital abutments. The following parameters were assessed at baseline, phase 1, 3 and 4 (1 year follow up) – CAL, Probing depth, Distance between CEJ/ cervical crown margin and alveolar crest of the abutment teeth (radiograph).
Results: Statistical analysis carried out by SPSSV22 software revealed no significant changes in probing depth and CAL (p>0.05) and significant changes in radiographic bone levels (p<0.05) in vital abutments whereas significant changes in probing depth and CAL from baseline to the end of 2 years (p<0.05) with no changes in radiographic parameters (p>0.05) with non vital abutments. However, significant differences were observed between vital and non vital abutments with regard to probing depth at the end of 2years, CAL and radiographic bone levels at 6months, 1 year and 2 years (p<0.05)
Conclusion: The response of the periodontal tissues to the PFM material used on fixed prosthesis on both vital and non vital abutment teeth although favorable, were marginally better in vital abutments.
Posttraumatic Stress Disorder, Depression, Anxiety, and Persistence of Methotrexate and TNF Inhibitors in Patients with Rheumatoid Arthritis
Authors: Desilet Luke W. , England Bryant R. , Michaud Kaleb , Barton Jennifer L. , Mikuls Ted R. , Baker Joshua F. 
Published: September 2020

ObjectiveTo examine the relationship of posttraumatic stress disorder (PTSD) with earlier treatment discontinuation and medication adherence in US veterans with rheumatoid arthritis (RA).MethodsVeterans Affairs (VA) administrative data (2005‐2014) were used to define unique dispensing episodes of methotrexate (MTX) and tumor necrosis factor inhibitors (TNFi) for veterans with RA. Diagnosis codes were used to categorize patients into mutually exclusive groups: PTSD (with/without depression/anxiety), depression/anxiety without PTSD, and neither psychiatric diagnosis. Multivariable Cox proportional hazards models were used to evaluate associations between psychiatric diagnoses and time to disease‐modifying antirheumatic drug discontinuation (lapse in refill >90 days). Multivariable logistic regression was used to examine associations of diagnoses with medication nonadherence (proportion of days covered <0.8).ResultsThere were 15 081 dispensing episodes of MTX and 8412 dispensing episodes of TNFi. PTSD was independently associated with a greater likelihood of earlier discontinuation of both MTX (hazard ratio [HR] 1.15 [1.10‐1.21]) and TNFi (HR 1.20 [1.13‐1.28]). Depression/anxiety had a comparable risk of discontinuation for both MTX (HR 1.14 [1.10‐1.19]) and TNFi (HR 1.16 [1.10‐1.22]). Depression/anxiety, but not PTSD, was associated with higher odds of MTX (odds ratio [OR] 1.12 [1.03‐1.22]) and TNFi (OR 1.14 [1.02‐1.27]) nonadherence.ConclusionVeterans with RA and comorbid PTSD, depression, or anxiety had poor persistence of MTX and TNFi therapies. These results suggest that earlier discontinuation and low adherence to therapy among patients with RA with these psychiatric comorbidities may contribute to worse disease outcomes. Mechanisms by which these comorbidities contribute to lower adherence deserve further investigation and may lead to targeted interventions to improve disease outcomes.
Z‐Scheme 2D/2D Heterojunction of CsPbBr3/Bi2WO6 for Improved Photocatalytic CO2 Reduction
Authors: Jiang Yong , Chen Hong‐Yan , Li Jun‐Yan , Liao Jin‐Feng , Zhang Hong‐Hong , Wang Xu‐Dong , Kuang Dai‐Bin 
Published: September 2020

AbstractHeterojunction engineering, especially 2D/2D heterojunctions, is regarded as a quite promising strategy to manipulate the photocatalytic performance of semiconductor catalysts. In this manuscript, a direct Z‐scheme 2D/2D heterojunction of CsPbBr3/Bi2WO6 is designed and fabricated by a simple electrostatic self‐assembly process. By using ultrathin nanosheets with several atomic layers as the building blocks, a close CsPbBr3/Bi2WO6 heterointerface over large area with quite a short charge transport distance is obtained, which enables a valid Z‐scheme interfacial charge transfer between Bi2WO6 and CsPbBr3 and thus boosts charge separation. The CsPbBr3/Bi2WO6 heterojunction exhibits a superior photocatalytic performance toward CO2 reduction. By incorporating Pt nanoparticles as the cocatalyst, a high photoelectron consumption rate of 324.0 µmol g−1 h−1 under AM 1.5G irradiation (150 mW cm−2) is obtained, which is 12.2 fold higher than that of CsPbBr3 nanosheets. Moreover, a stable product yield of up to 1582.0 µmol g−1 and electron consumption yield of 8603.0 µmol g−1 for photocatalytic CO2 reduction to CO (11.4%) and CH4 (84.3%) can be achieved after 30 h of continuous catalytic reaction. The accelerated photogenerated charge transfer and spatial charge separation are investigated in detail by ultrafast spectra, photoelectrochemical test, and Kelvin probe force microscopy.
Bifunctional 3D Hierarchical Hairy Foam toward Ultrastable Lithium/Sulfur Electrochemistry
Authors: Zeng Zhipeng , Li Wei , Chen Xiujuan , Liu Xingbo 
Published: September 2020

AbstractThe dendrite formation resulting from the irregular lithium deposition and the infinite volume expansion in lithium anodes significantly impede their commercialization for high energy applications. Herein, it is demonstrated that carbon nanofibers (CNFs) grown in situ on a nickel foam (CNF@Ni) can locally change the Li stripping/plating behavior by reducing the nucleation overpotential and regulating the electric field distribution. The 3D conductive hairy foam with a hierarchical structure can provide sufficient active sites for lithium nucleation. In addition, the numerous CNFs with protuberant tips can act as the charge centers and significantly increase the electrochemically active surface area, resulting in the locally reduced and uniformly distributed current density. The symmetric cells using CNF@Ni‐Li electrodes can achieve ultralong lifespan with low voltage hysteresis up to 1000 h. More remarkably, the CNF@Ni hairy foam can simultaneously enable reliable sulfur electrochemistry. The corresponding Li‐S full cell shows excellent cycle stability with a high capacity of ≈400 mAh g−1 at 5 C after 800 cycles. This work provides an exemplary way to concurrently address the challenges in lithium and sulfur electrodes toward the development of high‐performance Li–S batteries.
Long‐Term Retention of Low‐Power, Nonvolatile Organic Transistor Memory Based on Ultrathin, Trilayered Dielectric Containing Charge Trapping Functionality
Authors: Lee Changhyeon , Pak Kwanyong , Choi Junhwan , Kim Min Ju , Cho Byung Jin , Im Sung Gap 
Published: September 2020

AbstractA new strategy for multilayer stacking using charge trapping layer (CTL) is proposed and a new CTL material is synthesized, which contains a trilayer dielectric with the total thickness less than 28 nm, deposited by initiated chemical vapor deposition (iCVD) process. 2.6 nm thick poly(1,3,5‐trimethyl‐1,3,5‐trivinyl cyclotrisiloxane) (pV3D3) and 19 nm thick poly(1,4‐butanediol diacrylate) (pBDDA) are employed as tunneling and blocking dielectric layers, respectively. A 6 nm thick ultrathin charge trapping layer containing hydroxyl group is inserted between the tunneling and the blocking layers for stable, long‐term memory operation. For this purpose, a homogeneous copolymer of 1,4‐butanediol diacrylate and 2‐hydroxyethyl acrylate is newly synthesized. The fabricated memory with the trilayer dielectric shows larger than 5.8 V of memory window at low programming/erasing voltage of 16 V. The retention characteristics of the low‐power organic memory device is improved significantly with the drain current decrease less than 0.40 order after 108 s, corresponding to one of the longest retention time periods obtained from organic NVM reported to date. The low‐power organic NVM could also be integrated on flexible substrate, which is fully operational even under 2.72% of applied strain.
Contact Aging Enhances Adhesion of Micropatterned Silicone Adhesives to Glass Substrates
Authors: Thiemecke Jonathan , Hensel René 
Published: September 2020

AbstractThe transfer of biological concepts into synthetic micropatterned adhesives has recently enabled a new generation of switchable, reversible handling devices. Over the last two decades, many design principles have been explored that helped to understand the underlying mechanics and to optimize such adhesives for certain applications. An aspect that has been overlooked so far is the influence of longer hold times on the adhesive contacts. Exemplarily, the pull‐off stress and work of separation of a micropatterned adhesive specimen are enhanced by factors 3 and 6, respectively, after 1000 min in contact with a glass substrate. In addition to such global measures, the increase of adhesion of all individual micropillars is analyzed. It is found that contact aging varied across the microarray, as it drastically depends on local conditions. Despite great differences on the micropillar scale, the adhesion of entire specimens increased with very similar power laws, as this is determined by the mean contact ageing of the individual structures. Overall, contact aging must be critically evaluated before using micropatterned adhesives, especially for long‐term fixations and material combinations that are chemically attractive to each other.
Structural Manipulation of Phase Transitions by Self‐Induced Strain in Geometrically Confined Thin Films
Authors: Kalcheim Yoav , Adda Coline , Salev Pavel , Lee Min‐Han , Ghazikhanian Nareg , Vargas Nicolás M. , del Valle Javier , Schuller Ivan K. 
Published: September 2020

AbstractStrain engineering is a well‐known method often used to tune material properties in thin films. The most studied sources of strain are lattice mismatch and differential thermal contraction between the substrate and film. However, in materials which undergo a structural phase transition (SPT), a third and often overlooked source of strain may play a very significant role. If the substrate confines the area of the film, the SPT may induce stress which changes the evolution of the transition. This is a 2D analog of the isochoric phase transition between water and ice, where the freezing point drops below 0 °C. To illustrate this, the prototypical Mott insulator V2O3 which has an SPT coupled to a metal–insulator transition is used to show how self‐induced strain can drastically alter structural and electronic properties. This effect provides an elegant approach for mapping the phase diagram of the SPT and the transitions coupled to it. Moreover, the magnitude of self‐straining is tunable by modifying the substrate morphology. This effect may be important for numerous materials which exhibit an SPT and are subjected to geometrical constraints.
Highly Sensitive InSb Nanosheets Infrared Photodetector Passivated by Ferroelectric Polymer
Authors: Zhang Shukui , Jiao Hanxue , Wang Xudong , Chen Yan , Wang Hailu , Zhu Liqing , Jiang Wei , Liu Jingjing , Sun Liaoxin , Lin Tie , Shen Hong , Hu Weida , Meng Xiangjian , Pan Dong , Wang Jianlu , Zhao Jianhua , Chu Junhao 
Published: September 2020

AbstractIndium antimony is a direct, narrow bandgap III–V semiconductor with ultrahigh carrier mobility and an attractive optoelectronic device candidate for use in the visible to infrared region. Here, an infrared (IR) photodetector based on high‐quality InSb nanosheets (NSs) is presented, which shows a clear photoresponse over a broad spectral range from visible (637 nm) to infrared (4.3 µm). Due to the high surface‐to‐volume ratio of nanostructured materials, defects on the sample surface can affect performance, which is a disadvantage for the ambipolar InSb photodetectors. To eliminate the impact of sample surface defects on performance, the surface of the sample is passivated with a ferroelectric film and the mechanism of increased sensitivity is explored. After covering the protective layer, the performance of the detector is greatly improved. The responsivity and detectivity of the photodetector are 311.5 AW−1 and 9.8 × 109 Jones, respectively. Compared with devices before passivation, the dark current is two orders of magnitude lower, the responsivity is 20 times higher, and the photoresponse time is shortened from seconds to the order of milliseconds. These InSb NSs with their outstanding photoelectric properties have great potential for developing next‐generation nanoscale optoelectronic devices.
Flexible/Stretchable Supercapacitors with Novel Functionality for Wearable Electronics
Authors: Keum Kayeon , Kim Jung Wook , Hong Soo Yeong , Son Jeong Gon , Lee Sang‐Soo , Ha Jeong Sook 
Published: September 2020

AbstractWith the miniaturization of personal wearable electronics, considerable effort has been expended to develop high‐performance flexible/stretchable energy storage devices for powering integrated active devices. Supercapacitors can fulfill this role owing to their simple structures, high power density, and cyclic stability. Moreover, a high electrochemical performance can be achieved with flexible/stretchable supercapacitors, whose applications can be expanded through the introduction of additional novel functionalities. Here, recent advances in and future prospects for flexible/stretchable supercapacitors with innate functionalities are covered, including biodegradability, self‐healing, shape memory, energy harvesting, and electrochromic and temperature tolerance, which can contribute to reducing e‐waste, ensuring device integrity and performance, enabling device self‐charging following exposure to surrounding stimuli, displaying the charge status, and maintaining the performance under a wide range of temperatures. Finally, the challenges and perspectives of high‐performance all‐in‐one wearable systems with integrated functional supercapacitors for future practical application are discussed.
Metal‐Free Halide Perovskite Single Crystals with Very Long Charge Lifetimes for Efficient X‐ray Imaging
Authors: Song Xin , Cui Qingyue , Liu Yucheng , Xu Zhuo , Cohen Hagai , Ma Chuang , Fan Yuanyuan , Zhang Yunxia , Ye Haochen , Peng Zhanhui , Li Ruipeng , Chen Yonghua , Wang Jianpu , Sun Huaming , Yang Zhou , Liu Zhike , Yang Zupei , Huang Wei , Hodes Gary , Liu Shengzhong (Frank) , Zhao Kui 
Published: September 2020

AbstractMetal‐free halide perovskites, as a specific category of the perovskite family, have recently emerged as novel semiconductors for organic ferroelectrics and promise the wide chemical diversity of the ABX3 perovskite structure with mechanical flexibility, light weight, and eco‐friendly processing. However, after the initial discovery 17 years ago, there has been no experimental information about their charge transport properties and only one brief mention of their optoelectronic properties. Here, growth of large single crystals of metal‐free halide perovskite DABCO‐NH4Br3 (DABCO = N‐N′‐diazabicyclo[2.2.2]octonium) is reported together with characterization of their instrinsic optical and electronic properties and demonstration, of metal‐free halide perovskite optoelectronics. The results reveal that the crystals have an unusually large semigap of ≈16 eV and a specific band nature with the valence band maximum and the conduction band minimum mainly dominated by the halide and DABCO2+, respectively. The unusually large semigap rationalizes extremely long lifetimes approaching the millisecond regime, leading to very high charge diffusion lengths (tens of μm). The crystals also exhibit high X‐ray attenuation as well as being lightweight. All these properties translate to high‐performance X‐ray imaging with sensitivity up to 173 μC Gyair−1 cm−2. This makes metal‐free perovskites novel candidates for the next generation of optoelectronics.
The Experimentalist's Guide to the Cycloid, or Noncollinear Antiferromagnetism in Epitaxial BiFeO3
Authors: Burns Stuart R. , Paull Oliver , Juraszek Jean , Nagarajan Valanoor , Sando Daniel 
Published: September 2020

AbstractBismuth ferrite (BiFeO3) is one of the most widely studied multiferroics. The coexistence of ferroelectricity and antiferromagnetism in this compound has driven an intense search for electric‐field control of the magnetic order. Such efforts require a complete understanding of the various exchange interactions that underpin the magnetic behavior. An important characteristic of BiFeO3 is its noncollinear magnetic order; namely, a long‐period incommensurate spin cycloid. Here, the progress in understanding this fascinating aspect of BiFeO3 is reviewed, with a focus on epitaxial films. The advances made in developing the theory used to capture the complexities of the cycloid are first chronicled, followed by a description of the various experimental techniques employed to probe the magnetic order. To help the reader fully grasp the nuances associated with thin films, a detailed description of the spin cycloid in the bulk is provided. The effects of various perturbations on the cycloid are then described: magnetic and electric fields, doping, epitaxial strain, finite size effects, and temperature. To conclude, an outlook on possible device applications exploiting noncollinear magnetism in BiFeO3 films is presented. It is hoped that this work will act as a comprehensive experimentalist's guide to the spin cycloid in BiFeO3 thin films.
An Antioxidant Enzyme Therapeutic for COVID‐19
Authors: Qin Meng , Cao Zheng , Wen Jing , Yu Qingsong , Liu Chaoyong , Wang Fang , Zhang Jianjun , Yang Fengmei , Li Yanyan , Fishbein Gregory , Yan Sen , Xu Bin , Hou Yi , Ning Zhenbo , Nie Kaili , Jiang Ni , Liu Zhen , Wu Jun , Yu Yanting , Li Heng , Zheng Huiwen , Li Jing , Jin Weihua , Pang Shen , Wang Shuai , Chen Jianfeng , Gan Zhihua , He Zhanlong , Lu Yunfeng 
Published: September 2020

AbstractThe COVID‐19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. Herein it is a therapeutic based on catalase, an antioxidant enzyme that can effectively breakdown hydrogen peroxide and minimize the downstream reactive oxygen species, which are excessively produced resulting from the infection and inflammatory process, is reported. Catalase assists to regulate production of cytokines, protect oxidative injury, and repress replication of SARS‐CoV‐2, as demonstrated in human leukocytes and alveolar epithelial cells, and rhesus macaques, without noticeable toxicity. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID‐19.
Synergistic Interface‐Assisted Electrode–Electrolyte Coupling Toward Advanced Charge Storage
Authors: Sun Shuo , Rao Dewei , Zhai Teng , Liu Qi , Huang Hao , Liu Bo , Zhang Hongshen , Xue Liang , Xia Hui 
Published: September 2020

AbstractOwing to the limited charge storage capability of transitional metal oxides in aqueous electrolytes, the use of redox electrolytes (RE) represents a promising strategy to further increase the energy density of aqueous batteries or pseudocapacitors. The usual coupling of an electrode and an RE possesses weak electrode/RE interaction and weak adsorption of redox moieties on the electrode, resulting in a low capacity contribution and fast self‐discharge. In this work, Fe(CN)64− groups are grafted on the surface of Co3O4 electrode via formation of CoN bonds, creating a synergistic interface between the electrode and the RE. With such an interface, the coupled Co3O4–RE system exhibits greatly enhanced charge storage from both Co3O4 and RE, delivering a large reversible capacity of ≈1000 mC cm−2 together with greatly reduced self‐discharge. The significantly improved electrochemical activity of Co3O4 can be attributed to the tuned work function via charge injection from Fe(CN)64−, while the greatly enhanced adsorption of K3Fe(CN)6 molecules is achieved by the interface induced dipole–dipole interaction on the liquid side. Furthermore, this enhanced electrode–electrolyte coupling is also applicable in the NiO–RE system, demonstrating that the synergistic interface design can be a general strategy to integrate electrode and electrolyte for high‐performance energy storage devices.
Bandgap Renormalization in Monolayer MoS2 on CsPbBr3 Quantum Dots via Charge Transfer at Room Temperature
Authors: Adhikari Subash , Kim Ji‐Hee , Song Bumsub , Doan Manh‐Ha , Tran Minh Dao , Gomez Leyre , Kim Hyun , Gul Hamza Zad , Ghimire Ganesh , Yun Seok Joon , Gregorkiewicz Tom , Lee Young Hee 
Published: September 2020

AbstractMany‐body effect and strong Coulomb interaction in monolayer transition metal dichalcogenides lead to intrinsic bandgap shrinking, originating from the renormalization of electrical/optical bandgap, exciton binding energy, and spin‐orbit splitting. This renormalization phenomenon has been commonly observed at low temperature and requires high photon excitation density. Here, the augmented bandgap renormalization (BGR) in monolayer MoS2 anchored on CsPbBr3 perovskite quantum dots at room temperature via charge transfer is presented. The amount of electrons significantly transferred from perovskite gives rise to the large plasma screening in MoS2. The bandgap in heterostructure is red‐shifted by 84 meV with minimal pump fluence, the highest BGR in monolayer MoS2 at room temperature, which saturates with a further increase of pump fluence. Further, it is found that the magnitude of BGR inversely relates to Thomas–Fermi screening length. This provides plenty of room to explore the BGR within existing vast libraries of large bandgap van der Waals heterostructure toward practical devices such as solar cells, photodetectors, and light‐emitting‐diodes.