bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eating disorders among borderline patients: understanding the prevalence and psychopathology
Authors: Khosravi Mohsen 
Published: April 2020

Abstract
Background: Common comorbidity and the shared psychopathology in borderline personality disorder (BPD) and feeding and eating disorder (FED) resulted in conceptualization of the relationship theory between disordered eating behaviors (DEB), alexithymia, depression, and anxiety. Therefore, the present study aims at investigating the FED prevalence in patients with BPD and evaluating the relationship between DEB, alexithymia, anxiety, and depression.Methods: This cross-sectional study was performed from August 2018 to November 2019; 110 patients with BPD and 110 healthy people were studied in this research. The participants were selected by systematic random sampling out of the patients referring to Baharan psychiatric hospital in Zahedan, Iran, with the sampling interval of 3. The subjects were evaluated by demographic data form, the 26-item eating attitudes test (EAT-26), 20-item Toronto alexithymia scale (TAS-20), Beck anxiety disorder (BAI), and Beck depression inventory-II (BDI-II).Results: The results show a 65.4% (n = 72) prevalence of FED in borderline patients; the highest and lowest prevalence rates are reported for avoidant/restrictive food intake disorder (ARFID) and bulimia nervosa, respectively. The highest mean score of TAS-20 is reported in anorexia nervosa. The regression analysis results show that anxiety and depression play a mediating role in the relationship between alexithymia and DEB.Conclusions: The results suggest that alexithymia should be paid clinical attention as a trait and distress-independent construct in the BPD and FED comorbidity.
Cross-Contamination by Disinfectant Towelettes Varies by Product Chemistry and Strain
Authors: Voorn Maxwell , Goss Summer , Nkemngong Carine , Li Xiaobao , Teska Peter , Oliver Haley F 
Published: April 2020

Abstract
Background: Disinfectant products are used frequently on environmental surfaces (e.g. medical equipment, countertops, patient beds) and patient care equipment within healthcare facilities. The purpose of this study was to assess the risk of cross-contamination of Staphylococcus aureus and Pseudomonas aeruginosa during and after disinfection of predetermined surface areas with ready-to-use (RTU) pre-wetted disinfectant towelettes.Methods: This study tested six disinfectant towelette products against S. aureus ATCC CRM-6538 and P. aeruginosa strain ATCC-15442 on Formica surfaces. Each disinfectant was evaluated on a hard nonporous surface and efficacy was measured every 0.5 m 2 using a modified version of EPA MLB SOP-MB-33 to study the risk of cross-contamination.Results: We found that all of the wipes used in this study transferred P. aeruginosa and S. aureus from an inoculated surface to previously uncontaminated surfaces. Disinfectant towelettes with certain chemistries also retained a high level of viable bacteria after disinfection of the surface area. The cross-contamination risk also varied by product chemistry and bacterial strain.Conclusion: Disinfectant wipes can cross-contaminate hard nonporous surfaces and retain viable bacterial cells post-disinfection, especially over larger surface areas. This highlights a need to further investigate the risk disinfectant wipes pose during and post-disinfection and guidance on maximum surface areas treated with a single towelette.
Exercise promotes satellite cell contribution to myofibers in a load-dependent manner
Authors: Masschelein Evi , D'Hulst Gommaar , Zvick Joel , Hinte Laura , Soro-Arnaiz Inés , Gorski Tatiane , von Meyenn Ferdinand , Bar-Nur Ori , De Bock Katrien 
Published: April 2020

Abstract
Background Satellite cells (SCs) are required for muscle repair following injury and are involved in muscle remodeling upon muscular contractions. Exercise stimulates SC accumulation and myonuclear accretion. To what extent exercise training at different mechanical loads drive SC contribution to myonuclei however is unknown. Results By performing SC fate tracing experiments, we show that 8-weeks of voluntary wheel running increased SC contribution to myonuclei in mouse plantar flexor muscles in a load-dependent but fiber type-independent manner. Increased SC fusion however was not exclusively linked to muscle hypertrophy as wheel running without external load substantially increased SC fusion in the absence of fiber hypertrophy. Due to nuclear propagation, nuclear fluorescent fate tracing mouse models were inadequate to quantify SC contribution to myonuclei. Ultimately, by performing fate tracing at the DNA level, we show that SC contribution mirrors myonuclear accretion during exercise. Conclusions Collectively, these findings provide direct evidence that mechanical load during exercise independently promotes SC contribution to existing myofibers.
Cerenkov luminescence imaging is an effective preclinical tool for assessing colorectal cancer PD-L1 levels in vivo
Authors: Zhao Sheng , Pan Wen-Bin , Jiang Hui-Jie , Zhang Rong-Jun , Jiang Hao , Liang Zong-Hui , Hu Hong-Bo 
Published: April 2020

Abstract
Background : Preclinical and clinical studies have demonstrated that immunotherapy has effectively delayed tumor progression, and the clinical outcomes of anti-PD-1/PD-L1 therapy were related to PD-L1 expression level in the tumors. A 131 I-labeled anti-PD-L1 monoclonal antibody tracer, 131 I-PD-L1-Mab, was developed to study the target ability of non-invasive Cerenkov luminescence imaging in colorectal cancer xenograft mice.Method: Anti-PD-L1 monoclonal antibody labeled with 131 I( 131 I-PD-L1-Mab), and in vitro binding assays were used to evaluate the affinity of 131 I-PD-L1-Mab to PD-L1 and their binding level to different colorectal cancer cells, and compared with flow cytometry, western blot analysis, and immunofluorescence staining. The clinical application value of 131 I-PD-L1-Mab was evaluated through biodistribution and Cerenkov luminescence imaging, and different tumor-bearing models expressing PD-L1 were evaluated.Results: 131 I-PD-L1-Mab showed high affinity to PD-L1, and the equilibrium dissociation constant was 1.069×10 -9 M. The competitive inhibition assay further confirmed the specific binding ability of 131 I-PD-L1-Mab. In four different tumor-bearing models with different PD-L1 expression, the biodistribution and Cerenkov luminescence imaging showed that the RKO tumors demonstrated the highest uptake of the tracer 131 I-PD-L1-Mab, with a maximum uptake of 1.613 ± 0.738% ID/g at 120 h.Conclusions: There is a great potential for 131 I-PD-L1-Mab noninvasive Cerenkov luminescence imaging to assess the status of tumor PD-L1 expression and select patients for anti-PD-L1 targeted therapy.
Three-dimensional reconstruction of welding pool surface by binocular vision
Authors: Gu Zunan , Chen Ji , Wu Chuansong 
Published: April 2020

Abstract
Welding pool geometry includes plenty of welding quality information. The observation and reconstruction of the welding pool surface is the basis of developing intelligent control system for welding process to substitute skilled welders. The binocular vision system was ameliorated to capture images of welding pool surface by suppressing the strong arc interference during gas metal arc welding (GMAW). Combining and improving the algorithms of speeded up robust features, binary robust invariant scalable keypoints and KAZE, the feature information of points (i.e. RGB value, pixel coordinates and so on) was extracted as the feature vector of the welding pool surface. Based on the characteristic of welding images, the mismatch elimination algorithm was developed to increase the accuracy of image matching algorithms. The world coordinates of matching feature points was calculated to reconstruct the 3D shape of the welding pool surface. The effectiveness and accuracy of reconstruction for welding pool surface were verified by the experimental results.
Effectiveness of exergames for improving mobility and balance in older adults: A systematic review and meta-analysis.
Authors: Pacheco Thaiana Barbosa Ferreira , de Medeiros Candice Simões Pimenta , de Oliveira Victor Hugo Brito , Vieira Edgar Ramos , Cavalcanti Fabrícia Azevêdo da Costa 
Published: April 2020

Abstract
Background: Exergaming is a fun, engaging, and interactive form of exercising and it may help overcome some of the traditional exercise barriers and help improve adherence by older adults providing therapeutic applications for balance recovery and functional mobility. The purpose of this systematic review is to summarize the effects of exergames in older adults’ mobility and balance. Methods: The PRISMA guidelines for systematic reviews were followed. The following databases were searched from inception to August 2019: Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PEDro, CINAHL and INSPEC. We selected randomized controlled trials that assessed the effects of exergames on balance or mobility of older adults without neurological conditions, in comparison to no intervention or health education. Two review authors independently screened the trials titles and abstracts and identified trials for inclusion according to the eligibility criteria. Trial selection presented an almost perfect agreement between the authors regarding the interrater reliability (kappa = 0.84; p<0,001). Then, a descriptive analysis of the quantitative data was performed to summarize the evidence. Meta-analysis was carried using Revman. Random effects model was used to compute the pooled prevalence at 95% confidence interval. Results: After screening 822 trials, twelve trials comparing exergames with no intervention were included. A total of 1520 older adults participated in the studies, with mean age of 76±6 years for the experimental group and 76±5 years for the control group. Three studies found significant improvements in balance based on center of pressure sway and Berg Balance Scale scores. Three studies found improved mobility based on the timed up and go, 30-second chair stand, and 8-foot up and go test. Conclusions: Exergames improved balance and mobility in older adults without neurological disorders. High quality studies with standardized assessment protocols are necessary to improve evidence.
Prevalence of alcohol use and associated factors among Dilla University Students, Dilla Town, Southern Ethiopia. 2018
Authors: Chekole Yigrem Ali 
Published: April 2020

Abstract
Introduction Compared to other deadly communicable diseases, Psychoactive Substance use is among the leading cause of death. Repeated use linked to addiction, dependence and predisposition for criminal and antisocial behaviors. Even though drug use in Africa relatively is short; however the abuse of drug in Africa is escalating rapidly. Substances use is also one of the most burning and growing public health problems in Ethiopia, as in many developing countries; alcohol is the most frequently used substance. Objective To Assess the Prevalence of alcohol Use and Associated factors among Dilla University undergraduate students in Southern Ethiopia. 2018. Methods An Institution based cross -sectional study was conducted at Dilla University among undergraduate regular students from January-February. Systematic random sampling technique was used to get a total of 803 samples of students from each year and department of the university. The collected data was coded, entered in to EPI-INFO version7.1 and analyzed by using SPSS version 20. Crude and adjusted OR were analyzed using logistic regression and the level of significance of association was determined at P- value <0.05. Result A total of 803 participants were interviewed with a response rate of 91.7%. Among the Participants, alcohol use was found to be 67.6%. (41.8%; n=336). Being 4 th year students (AOR =2.66, 95% CI: 1.64, 4.31), having friends who use substance (AOR=1.53, 95% CI: 1.09, 2.1), being Khat user (AOR= 1.48, 95% CI: 1.05, 2.09) and being Cigarette smoker (AOR=1.76, 95% CI: 1.09, 2.84) were found to be significantly associated with alcohol use. Conclusion Half of the participants found to have alcohol use. Therefore, early prevention, detection and alleviating of alcohol use should be implemented among students in the university.
Quantitative structure-property relationship study of alcohols water solubility based on a new model combined modified autocorrelation method and electro-topological indices
Authors: Jermouni Chaymae , Nohair Mohamed 
Published: April 2020

Abstract
In this study, structure water solubility modeling was performed to describe a set of 50 of aliphatic alcohols in a Quantitative Structure-Property Relationship model by developing of two descriptors types based on multifunctional autocorrelation method, which gives a general description of whole molecule; and electro-topological descriptors. The index combines the topological nature with electronic state of the atom. The Modified Autocorrelation Method was used in structure–property relationships to describe the local environment of the hydroxyl group. For the statistical studies, Multiple Linear Regression, Artificial Neural Networks and Principal Components Analysis were used. The approach efficiency approach was evaluated through the predictive ability of models by leave-p-Out cross-validation method. The coefficient of determination and errors of descriptors combination calculated respectively by multiple linear regression and artificial neural networks were r= 0.99, s = 0.18 and r = 0.99, s = 0.32. In order to simplify components computation, the molecules were coded by means of SMILES system and stored as input files. The results showed that aliphatic alcohols solubility is dominated by the shape and molecule branching, also the electro-topological descriptors had a considered model effect.
A high-efficiency hospital emergency-response mode is key to successful treatment of COVID-19 patients in Zhuhai
Authors: Huang Jin , Li Zhonghe , Qu Xiujuan , Zheng Xiaobin , Tu Changli , Shi Honglei , Chen Meizhu , Tan Cuiyan , Liu Jing , Shan Hong 
Published: April 2020

Abstract
Background: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and has since rapidly spread throughout China. The mortality rates of novel coronavirus pneumonia (NCP) in severe and critical cases are very high. In this public-health emergency, a high-efficiency administrative emergency-response mode in designated hospitals is needed. Method: As an affiliated hospital of Sun Yat-sen University, ours, the Fifth Affiliated Hospital, is the only one designated for the diagnosis and treatment of COVID-19 in Zhuhai, a mid-sized city. The NCP department, for which the president of the hospital is also the direct administrative lead, was established at an early stage of the epidemic at our hospital. This department includes core members of the pulmonary and critical-care medicine (PCCM) specialist and multidisciplinary team. Rather than adhering to national guidelines on NCP, we have focused on individualized treatment, timely adjustment thereof and management strategies in working with COVID-19 patients based on the professional opinions of a professor of respiratory medicine and an expert group. Results: (1) High working efficiency: As of March 2, 2020, we have completed 2974 citywide consultations and treatment of 366 inpatients, including 101 who were diagnosed with COVID-19. (2) Excellent therapeutic effect: Of the 101 patients hospitalized with confirmed COVID-19, only 1 has died, and the rest were all cured and discharged. No secondary hospital infection, pipeline infection or pressure sores were found in any patient. (3) Finding and confirming person-to-person transmission characteristic of COVID-19 prior to the official press conference: Strengthened protection is key to zero infection among the healthcare providers and medical faculty, as well as to a lower rate of second-generation infectious patients. (4) Timely adjustment of management and treatment strategy prior to guideline updates: The first evidence of digestive-tract involvement in COVID-19 has been found, and the earliest clinical trial of chloroquine in the treatment of the disease was carried out at our hospital. Conclusions: At our hospital, establishment of an NCP department, which is directly administered by the hospital president and specialized operation guided by a professor of respiratory medicine, has been key to our success in managing and treating COVID-19 patients. Our hospital’s emergency-response mode could provide a reference for other hospitals and cities in this epidemic situation.
Improved high-order adjacent vertex assignment sequence for similarity vertices and isomorphism identification of planar kinematic chains
Authors: Sun Liang , Ye Zhizheng , Lu Fuwei , Cui Rongjiang , Wu Chuanyu 
Published: April 2020

Abstract
Isomorphism identification is fundamental to synthesis and innovative design of kinematic chains (KCs). The identification can be performed accurately by using the similarity of KCs. However, there are very few researches on isomorphism identification based on the properties of similarity vertices. In this paper, an improved high-order adjacent vertex assignment (IHAVS) sequence method is proposed to seek out the similarity vertices and identify the isomorphism of the planar KCs. First, the specific definition of IHAVS is described. Through the calculation of the IHAVS, the adjacent point value sequence reflecting the uniqueness of the structural features is established. Based on the value sequence, all possible similarity vertices, corresponding relations and isomorphism discrimination can be realized. By checking the topological diagrams of KCs of different number of links, the correctness of the proposed method are verified. Finally, the method is used to find the similarity vertices of all the 9-link 2-DOF(degree of freedom) planar KCs.
The preliminary comparative results between Covid-19 and non-Covid-19 patients in Western China
Authors: Yanzi Li , Hongxia Li , Jianfeng Han , Lin Yang 
Published: April 2020

Abstract
Background: This study aims to investigate the comparative clinical characteristics of Covid-19 and non-Covid-19 patients.Methods: Fifteen Covid-19 and 93 non-Covid-19 patients were included in RNA testing. All epidemiological and clinical data were collected and analyzed, and then comparative results were carried out.Results: Covid-19 patients were older (46.40±18.21 years vs 34.43±18.80 years) and hada higher body weight (70.27±10.67 kg vs 60.54±12.33 kg, P<0.05). The main symptoms that were similar between Covid-19 and non-Covid-19 patients, and Covid-19 patients showed a lower incidence of sputum production (6.67% vs 45.16%, P<0.01) and a lower white-cell count (4.83×109/L vs 7.43×109/L) and lymphocyte count (0.90×109/L vs 1.57×109/L) (P<0.01). Although there were no differences, C-reactive protein and interleukin-6 were elevated in Covid-19 patients. The sensitivity and negative predictive value of CT images were 0.87 and 0.97, respectively. Covid-19 patients showed a higher contact history of Wuhan residents (80% vs 30.11%) and higher familial clustering (53.33% vs 8.60%, P<0.001). Covid-19 patients showed a higher major adverse events (ARDS, 13.33%; death, 6.67%; P<0.05).Conclusion: Our results suggested that Covid-19 patients had a significant history of exposure and familial clustering and a higher rate of severe status; biochemical indicators showed lymphocyte depletion.
A genome-wide association study of deviated nasal septum using UK Biobank cohort
Authors: Liu Li , Wu CuiYan , Dai Xiaoxia , Wen Yan , Cheng Shiqiang , Cheng Bolun , Li Ping , Qi Xin , Ma Mei , Zhang Lu , Liang Chujun , Chu Xiaomeng , Ye Jing , Yao Yao , Guo Xiong , Zhang Feng 
Published: April 2020

Abstract
Background

Deviated nasal septum (DNS) is a common otolaryngology disease. The genetic mechanism underlying DNS remains largely unknown.

Methods

Totally, 2, 978 DNS patients and 2,978 randomly selected controls from the UK biobank were used in this study. Genotyping was done using the Affymetrix UK BiLEVE Axiom or UK Biobank Axiom array. Genome-wide association study (GWAS) was performed by PLINK 2.0, using age, sex, population structure PC1, PC2 and PC3 as covariates. eQTLs analysis and gene set enrichment analysis (GSEA) were also performed to explore the functional relevance of identified loci with DNS.

Results

GWAS identified multiple candidate genetic loci for DNS, such as rs75651247 located in DLGAP1 (β=-5.3398, P=9.31×10-8), rs141366706 located in CCND3 (β=-4.7036, P=2.56×10-6), rs76606504 located in FAF1 (β=-4.5013, P=6.76×10-6), and rs142537880 located in SVIL (β= 4.4336, P=9.27×10-6). GSEA detected multiple DNS associated gene sets or pathways, such as KEGG_CALCIUM_SIGNALING_PATHWAY (FDR=3.35×10-3, P=5×10-5) and DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP (FDR=1.60×10-3, P=5×10-5).

Conclusions

Our study reported multiple candidate genes and gene sets for DNS, providing novel clues for understanding the genetic mechanism of DNS.
Effects of dialysis modality choice on survival of end-stage renal disease patients in southern China: A retrospective cohort study
Authors: He Zhiren , Zhang Difei , Mo Yenan , Zhang La , Lin Junjie , Lu LiMing , Su Guobin , Huang Jingrao , Gu Yewen , Zhang Ying , Lin Jingxia , Yuan Fengling , Peng Yu , Liang Hui , Zhao Daixing , Lu Fuhua , Liu Xusheng , Hou Haijing , Wang Lixing 
Published: April 2020

Abstract
Background Up to date, whether hemodialysis (HD) or peritoneal dialysis (PD) is a better choice for end-stage renal disease (ESRD) patients has been debatable. Few study comparing HD and PD was from China, a large country with the largest number of dialysis patients in the world. Method A retrospective cohort study was conducted on ESRD patients who began renal replace treatment from January 1st, 2012 and December 31st, 2017 in Guangdong Provincial Hospital of Chinese Medicine. We used propensity scoring match model to balance the baseline conditions and Cox's multivariate regression analysis to compare mortality between HD and PD patients, and evaluated the relationship between mortality and various baseline covariates. Results 436 HD patients and 501 PD patients were included and we found that PD patients had better survival than HD patients (The 1-, 3- and 5-year survival rates were 98.1% vs 96.4%, 86.7% vs 83.0%, and 73.4% vs 71.9%), even though the difference was not statistically significant. For younger ESRD patients (<=60 years old), the overall survival of PD was better than that of HD, but HD was associated with lower risk of death in the patients who were older than 70 years of age. This difference was still significant after adjustment for a variety of confounding factors. Female, cardiovascular disease, cholesterol, and HD are risk factors of all-cause mortality in the younger subgroup while PD is risk factor in the older subgroup. Conclusion Younger ESRD patients may be more suitable for PD, and the elderly for HD.