bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiota metabolic exchange is critical for colorectal cancer redox homeostasis and growth
Authors: Bell Hannah , Goyert Joshua , Kerk Samuel A. , Das Nupur K. , Lyssiotis Costas A. , Shah Yatrik M. 
Published: December 2020

AbstractIntestinal microbiota play a fundamental role in human health and disease. Microbial dysbiosis is a hallmark of colorectal cancer (CRC) as tumor stage-specific shifts potentiate tumor growth, influence the inflammatory microenvironment, and alter response to therapy. Recent work has demonstrated a critical role for microbial metabolite exchange in host response. However, the role of most microbial metabolites in colon cancer growth is unclear. To better understand how metabolic exchange between the microbiota and tumor epithelium alter CRC growth, a screen of the most abundant bacterially derived metabolites was assessed. Several metabolites were found to alter CRC growth, but reuterin most significantly suppressed CRC cell proliferation. Reuterin is a bifunctional metabolite containing both hydroxy and aldehyde functional groups. Reuterin is primarily synthesized from glycerol byLactobacillus reuteri,a commensal bacterium found throughout the gastrointestinal tract. We found that reuterin suppresses growth via alterations to the redox balance of CRC cells. Mechanistically, reuterin potentiates reactive oxygen species (ROS) which leads to irreversible cysteine oxidation and enhanced cell death. Supplementation of either antioxidants or hydrogen sulfide fully rescued growth, suggesting that reuterin is suppressing CRC growth through protein oxidation. These studies demonstrate the potential of reuterin to act as a potent chemotherapeutic for treating colorectal cancers.
Optogenetic analysis of Ca++transients inCaenorhabditis elegansmuscle cells during forward and reverse locomotion
Authors: Manjarrez Jacob R. , Shaw Magera , Mailler Roger 
Published: December 2020

ABSTRACTUnderstanding how an organism generates movement is an important step toward determining how a system of neurons produces behavior. With only 95 body wall muscles and 302 neurons,Caenorhabditis elegansis an attractive model organism to use in uncovering the connection between neural circuitry and movement. This study provides a comprehensive examination of the muscle cell activity used byC. elegansduring both forward and reverse locomotion. By tracking freely moving worms that express genetically encoded calcium indicators in their muscle cells, we directly measure the patterns of activity that occur during movement. We then analyzed these patterns using a variety of signal processing and statistical techniques. Although our results agree with many previous findings, we also discovered there is significantly different mean Ca++levels in many of the muscle cells during forward and reverse locomotion and, when considered independently, the dorsal and ventral muscle activation waves exhibit classical neuromechanical phase lag (NPL).
Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2in Vitro
Authors: Gammeltoft Karen A. , Zhou Yuyong , Galli Andrea , Offersgaard Anna , Pham Long V. , Fahnøe Ulrik , Feng Shan , Ramirez Santseharay , Bukh Jens , Gottwein Judith M. 
Published: December 2020

AbstractAntivirals targeting SARS-CoV-2 could improve treatment of COVID-19. We evaluated the efficacy of clinically relevant hepatitis C virus (HCV) NS3 protease inhibitors (PI) against SARS-CoV-2 and their interactions with remdesivir, the only antiviral approved for treatment of COVID-19. HCV PI showed differential potency in VeroE6 cell-based antiviral assays based on detection of the SARS-CoV-2 Spike protein. Linear PI boceprevir, telaprevir and narlaprevir had 50% effective concentrations (EC50) of ~40 μM. Among macrocyclic PI simeprevir, paritaprevir, grazoprevir, glecaprevir, voxilaprevir, vaniprevir, danoprevir and deldeprevir, simeprevir had the highest (EC50 15 μM) and glecaprevir the lowest (EC50 >178 μM) potency. Acyclic PI asunaprevir and faldaprevir had EC50 of 72 and 23 μM, respectively. ACH-806, an HCV NS3 protease co-factor NS4A inhibitor, had EC50 of 46 μM. For selected PI, potency was similar in human hepatoma Huh7.5 cells. Selectivity indexes, based on antiviral and cell viability assays, were highest for linear PI. In combination with remdesivir, linear PI boceprevir and narlaprevir showed antagonism, while macrocyclic PI simeprevir, paritaprevir and grazoprevir showed synergism with drug reduction indexes of up to 27 for simeprevir. Treatment of infected cultures with equipotent concentrations (1-fold EC50) of HCV PI revealed minor differences in barrier to SARS-CoV-2 escape. Complete viral suppression was achieved treating with ≥3-fold EC50 boceprevir or combination of 1-fold EC50 simeprevir with 0.4-fold EC50 remdesivir, not leading to significant viral suppression in single treatments. Considering potency, human plasma concentrations and synergism with remdesivir, simeprevir seemed the most promising compound for optimization of future antiviral treatments of COVID-19.
Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles
Authors: Kumar Sonu , Lin Xiaohe , Ngo Timothy , Shapero Benjamin , Sou Cindy , Allen Joel D. , Copps Jeffrey , Zhang Lei , Ozorowski Gabriel , He Linling , Crispin Max , Ward Andrew B. , Wilson Ian A. , Zhu Jiang 
Published: December 2020

ABSTRACTAntigen-specific B-cell sorting and next-generation sequencing (NGS) were combined to isolate HIV-1 neutralizing antibodies (NAbs) from mice and rabbits immunized with BG505 trimers and nanoparticles. Three mouse NAbs potently neutralize BG505.T332N and recognize a glycan epitope centered at the C3/V4 region, as revealed by electron microscopy (EM), x-ray crystallography, and epitope mapping. Three potent NAbs were sorted from rabbit B cells that target glycan holes on the BG505 envelope glycoprotein (Env) and account for a significant portion of autologous NAb response. We then determined a 3.4Å-resolution crystal structure for the clade C transmitted/founder Du172.17 Env with a redesigned heptad repeat 1 (HR1) bend. This clade C Env, as a soluble trimer and attached to a ferritin nanoparticle, along with a clade A Q482-d12 Env trimer, elicited distinct NAb responses in rabbits. Our study demonstrates that nanoparticles presenting gp41-stabilized trimers can induce potent NAb responses in mice and rabbits with Env-dependent breadth.TEASERMouse and rabbit NAbs elicited by gp41-stabilized trimers and nanoparticles neutralize autologous HIV-1 by targeting different epitopes
Narrowing the gap between consumer purchasing intention and behaviour through ecolabelling: a challenge for eco-entrepreneurism
Authors: Calderon-Monge Esther , Redondo-Rodriguez Roger-Guzman , Ramírez-Hurtado José M. 
Published: December 2020

PurposeThe gap between the self-declarations of buyers as responsible consumers and the purchase of sustainable products means that consumer knowledge needs to be examined in depth, to guide the initiatives of eco-entrepreneurs towards sectors and demands that will make them viable and to advance responsible production and consumption – Objective 12: Sustainable Development 2030. The purpose of this study is to analyse the profile of consumers in relation to the purchase of ecolabelled products and to establish relations between purchasing decisions with environmental, social and ethical factors.Design/methodology/approachMultiple correspondence analysis is applied to the results of a questionnaire administered to a sample of 407 consumers resident in Spain. Information is gathered on environmental, social and economic concerns and the importance consumers attach to certain product attributes such as ecolabels, price and quality.FindingsConsumers concerned over environmental, social and economic questions attached greater importance to information on ecolabels, principally within the textile, and drugstore sectors, followed by electrical and electronic appliances and the food sector. These consumers selected ecolabelled products with a good quality–price relationship.Originality/valueThe academic and business value of this research is its focus on the attributes of sustainable products so that eco-entrepreneurs may advance initiatives that are at once viable and sustainable, motivating consumers with concerns over environmental, social and economic issues.
Information-seeking strategy and likelihood of workplace health disclosure
Authors: Li Jo-Yun , Lee Yeunjae 
Published: December 2020

PurposeThis study seeks to address the question on the role of information-seeking behavior in dealing with uncertainty on workplace health disclosure from the perspectives of internal communication.Design/methodology/approachAn online survey was conducted with 409 full-time employees in large-sized companies in the United States.FindingsThe results showed that employees engage in proactive and passive information-seeking strategies when they are uncertain about their supervisors' reactions toward their health problems. Positive EOR and organizational climate would increase their intention to adopt inquiry strategy, whereas negative EOR and the climate would increase their intention to adopt monitoring strategy. Employees who adopt inquiry strategy tend to perceive the benefits of health disclosure, whereas those who adopt monitoring strategy tend to perceive the risks of health disclosure. If employees perceived increased benefits in terms of health disclosure, then they tend to disclose their health problems to their supervisors, and vice versa.Originality/valueThis study is among first to investigate workplace health disclosure decision-making from the perspectives of internal communication. These findings highlight the importance of excellent internal communications in employees' health disclosure decision-making process and support the proposition that proactive information-seeking is a strategy that contributes to uncertainty management in the workplace. This study also provides significant practical guidelines for corporate communication practitioners and leaders by establishing a safe and friendly environment where employees feel comfortable to disclose their health problems to supervisors.
Rethinking the role of the EU in enhancing European competitiveness
Authors: Ketels Christian , Porter Michael E. 
Published: December 2020

Purpose
This paper aims to review the evidence on Europe’s economic performance and on the role played by policies pursued at the European Union (EU) level, using the competitiveness framework as the conceptual lens.

Design/methodology/approach
Why has Europe not made more progress on upgrading its competitiveness over the past few decades, despite the many initiatives that the EU has launched?

Findings
It finds Europe’s sluggish performance to be driven by a failure to adjust the EU’s policy approach to fundamental changes in the competitiveness context and challenges faced by European economies.

Originality/value
Based on this analysis, the paper suggests a new role for the EU in supporting EU member countries and regions in achieving higher levels of competitiveness.
Reputations and corruption: Bell Pottinger in South Africa
Authors: Wöcke Albert , Mthombeni Morris , Cuervo-Cazurro Alvaro 
Published: December 2020

Learning outcomes
The case can be used in strategic management, international business or ethics courses. In strategic management courses, students will be able to identify political relationships as sources of a firm’s competitive advantage. Students will also understand the role of ethics in the firm’s competitive advantage. In international business courses, the students will be able to analyze the role that corruption and bribery play in the analysis of a country’s institutions. Students will also understand how corruption in a host country influences a firms’ decision to internationalize. Finally, students will understand the challenges that firms face when serving customers in other countries. In ethics courses, students will understand the nature of state/business corruption, i.e. the abuse of public office for private gain and the concept of state capture, i.e. managers controlling the political system for their advantage. Students will be able to analyze the decision of whether to collaborate with unethical partners or customers.

Case overview/synopsis
Bell Pottinger Private (BPP) was a British public relations (PR) firm with a successful but questionable reputation of helping famous critical figures and despots improve their public image. In 2016, Lord Tim Bell and the other leaders of BPP were asked to create a PR campaign for the Gupta family. The Guptas were a group of businessmen headed by three brothers who migrated from India to South Africa in the early 1990s. By the 2010s, they had built a business empire allegedly thanks to a corrupt relationship with the President of South Africa, Jacob Zuma and his family. The press and prosecutors were increasing their investigations on these relations. The case has two parts, which address two separate challenges and can be taught as standalone cases or in a sequence in two sessions.

Complexity academic level
MBA and Executive Education.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 5: International business.
Developing an information classification method
Authors: Bergström Erik , Karlsson Fredrik , Åhlfeldt Rose-Mharie 
Published: December 2020

Purpose
The purpose of this paper is to develop a method for information classification. The proposed method draws on established standards, such as the ISO/IEC 27002 and information classification practices. The long-term goal of the method is to decrease the subjective judgement in the implementation of information classification in organisations, which can lead to information security breaches because the information is under- or over-classified.

Design/methodology/approach
The results are based on a design science research approach, implemented as five iterations spanning the years 2013 to 2019.

Findings
The paper presents a method for information classification and the design principles underpinning the method. The empirical demonstration shows that senior and novice information security managers perceive the method as a useful tool for classifying information assets in an organisation.

Research limitations/implications
Existing research has, to a limited extent, provided extensive advice on how to approach information classification in organisations systematically. The method presented in this paper can act as a starting point for further research in this area, aiming at decreasing subjectivity in the information classification process. Additional research is needed to fully validate the proposed method for information classification and its potential to reduce the subjective judgement.

Practical implications
The research contributes to practice by offering a method for information classification. It provides a hands-on-tool for how to implement an information classification process. Besides, this research proves that it is possible to devise a method to support information classification. This is important, because, even if an organisation chooses not to adopt the proposed method, the very fact that this method has proved useful should encourage any similar endeavour.

Originality/value
The proposed method offers a detailed and well-elaborated tool for information classification. The method is generic and adaptable, depending on organisational needs.
Hope for the best and prepare for the worst. Do short-time work schemes help workers remain in the same firm?
Authors: Arranz José M. , García-Serrano Carlos , Hernanz Virginia 
Published: December 2020

PurposeThis paper investigates whether short-time work (STW) schemes were successful in their objective of maintaining employment and keeping workers employed within the same firms after the onset of the financial and economic crisis in 2008.Design/methodology/approachSpanish longitudinal administrative data has been used, making it possible to identify short-time work (STW) participation not only of workers but also of employers and allowing to know the future labour market status of participants and non-participants. Accordingly, treatment and control groups are defined, and Propensity Score Matching models estimated. The dependent variable is measured as the probability that an individual remained employed with the same employer in the future (one, two and three years) after implementation of a STW arrangement.FindingsOur results suggest that treated individuals are about 5 percentage points less likely to remain working with the same employer one year later than similar workers, and this negative effect of participation increases over time. Thus, STW schemes would not have the assumed effect of preventing unemployment by keeping the participants employed relative to non-participants.Research limitations/implicationsAs our analysis is based on the comparison of the employment trajectories of participant and non-participant workers in firms that have used STW arrangements, our findings cannot be interpreted as the job saving effects of either macro or micro studies carried out previously.Practical implicationsThe analysis carried out in the paper is complementary to the country-level and firm-level approaches that have been used in the empirical literature.Originality/valueWe adopt a worker-level approach. This is novel since no previous study has focused attention on the impact of STW participation on the subsequent labour market status of workers.
The current sustainability scenario of Industry 4.0 enabling technologies in Indian manufacturing industries
Authors: Pasi Bhaveshkumar Nandanram , Mahajan Subhash K. , Rane Santosh B. 
Published: December 2020

PurposeThe purposes of this research article are as follows: to explore the understanding of the Industry 4.0 (I4.0) concept among Indian manufacturing industries, to determine the motivating factors for I4.0 implementation, to identify I4.0 enabling technologies which are used by Indian manufacturing industries and assess their sustainability, to explore the impact of above identified enabling technologies on sustainability pillars, to determine how Indian manufacturing industries interpret the concept of I4.0 and to develop a road map for I4.0 implementation and sustainability.Design/methodology/approachTo perform this research work, a dual research methodology was adopted. Questionnaires were sent to 16 Indian manufacturing industries, and expert interviews were conducted with seven experts who have been practicing the I4.0 concept since the last three years in their business. Also, a sustainability measurement tool was developed to measure the sustainability of the used I4.0 enabling technologies.FindingsIn this research article, it is found that smart sensors and robot arms have high sustainability, whereas cyber physical systems (CPSs) and big data analytics have low sustainability. During an expert interview, it has been found that adoption of the I4.0 concept in Indian manufacturing industries is creating job loss fear in employees. Also, it is found that Indian workers must be trained to adopt and sustain I4.0 enabling technologies.Research limitations/implicationsThe sustainability of I4.0 enabling technologies in Indian manufacturing industries was indicated by analyzing responses received through questionnaires and expert interviews. There are other measures of sustainability which are beyond this study. Further studies are expected to fill the gap.Practical implicationsThe authors have explored reasons for low sustainability of I4.0 enabling technologies in Indian manufacturing industries, suggested a road map for its implementation and sustainability and identified the relationship between different parameters (such as job loss, job creation, workers’ qualification and business profit) and I4.0 sustainability, therefore helping Indian organizations to develop sustainable manufacturing systems based on the I4.0 concept.Originality/valueThis research article gives an idea about sustainability of I4.0 enabling technologies in Indian manufacturing industries.
The influence of narrative disclosure readability, information ordering and graphical representations on non-professional investors' judgment: evidence from an emerging market
Authors: El-Sayed Dalia Hussein , Adel Eman , Elmougy Omar , Fawzy Nadeen , Hatem Nada , Elhakey Farida 
Published: December 2020

PurposeThis study examines whether manipulation in attributes of corporate narrative disclosures and the use of graphical representations can bias non-professional investors' judgment towards firms' future performance, in an emerging market context.Design/methodology/approachThe authors conduct three different experiments with a 2 × 2 between-subjects design, using accounting and finance senior undergraduate students to proxy for the non-professional investors.FindingsResults show that simple (more readable) disclosures improve non-professional investors' judgment towards firms' future performance. In addition, it is found that non-professional investors are prone to a recency effect from the intentional ordering of narrative information, when using complex (less readable) narratives. However, no primacy effect is found, when using simple (more readable) disclosures. The results further provide evidence that the inclusion of graphical representations, along with the manipulated narrative disclosures, can moderate the recency effect of information order, when using less readable and complex narrative disclosures.Research limitations/implicationsThe results reveal that although the content of corporate disclosures can be objective, neutral and relevant, manipulation in textual features and the use of graphical presentations, can interact to impact how non-professional investors perceive and process the disclosed information. This study provides an Egyptian evidence regarding this issue, as the majority of prior studies concentrate on developed capital markets. In addition, it contributes to prior studies evaluating the appropriateness of the Belief Adjustment Model predictions about the effect of textual presentation order on decision-making, by providing evidence from an emerging market.Practical implicationsResults attempt to increase the awareness of investors and encourage them to use multiple sources of information to avoid the probable bias that can result from management's manipulation of narratives. In addition, the study could be of interest to regulators and standard-setters, where the results reveal the need for guidelines and regulations to guide the disclosure of narrative information and the use of graphical information in corporate reports.Originality/valueTo the best of the authors' knowledge, this is the first study to examine the effect of two impression management strategies in narrative disclosures (readability and information order), along with the use of graphical representations, on non-professional investors' judgment in an emerging market, like Egypt.