bluuebunny/crossref_metadata_2025_split huggingface dataset:
But what about...: cosmic rays, magnetic fields, conduction, and viscosity in galaxy formation
Authors: Hopkins Philip F , Chan T K , Garrison-Kimmel Shea , Ji Suoqing , Su Kung-Yi , Hummels Cameron B , Kereš Dušan , Quataert Eliot , Faucher-Giguère Claude-André 
Published: December 2019

ABSTRACTWe present and study a large suite of high-resolution cosmological zoom-in simulations, using the FIRE-2 treatment of mechanical and radiative feedback from massive stars, together with explicit treatment of magnetic fields, anisotropic conduction and viscosity (accounting for saturation and limitation by plasma instabilities at high β), and cosmic rays (CRs) injected in supernovae shocks (including anisotropic diffusion, streaming, adiabatic, hadronic and Coulomb losses). We survey systems from ultrafaint dwarf ($M_{\ast }\sim 10^{4}\, \mathrm{M}_{\odot }$, $M_{\rm halo}\sim 10^{9}\, \mathrm{M}_{\odot }$) through Milky Way/Local Group (MW/LG) masses, systematically vary uncertain CR parameters (e.g. the diffusion coefficient κ and streaming velocity), and study a broad ensemble of galaxy properties [masses, star formation (SF) histories, mass profiles, phase structure, morphologies, etc.]. We confirm previous conclusions that magnetic fields, conduction, and viscosity on resolved ($\gtrsim 1\,$ pc) scales have only small effects on bulk galaxy properties. CRs have relatively weak effects on all galaxy properties studied in dwarfs ($M_{\ast } \ll 10^{10}\, \mathrm{M}_{\odot }$, $M_{\rm halo} \lesssim 10^{11}\, \mathrm{M}_{\odot }$), or at high redshifts (z ≳ 1–2), for any physically reasonable parameters. However, at higher masses ($M_{\rm halo} \gtrsim 10^{11}\, \mathrm{M}_{\odot }$) and z ≲ 1–2, CRs can suppress SF and stellar masses by factors ∼2–4, given reasonable injection efficiencies and relatively high effective diffusion coefficients $\kappa \gtrsim 3\times 10^{29}\, {\rm cm^{2}\, s^{-1}}$. At lower κ, CRs take too long to escape dense star-forming gas and lose their energy to collisional hadronic losses, producing negligible effects on galaxies and violating empirical constraints from spallation and γ-ray emission. At much higher κ CRs escape too efficiently to have appreciable effects even in the CGM. But around $\kappa \sim 3\times 10^{29}\, {\rm cm^{2}\, s^{-1}}$, CRs escape the galaxy and build up a CR-pressure-dominated halo which maintains approximate virial equilibrium and supports relatively dense, cool (T ≪ 106 K) gas that would otherwise rain on to the galaxy. CR ‘heating’ (from collisional and streaming losses) is never dominant.
On the model of the circumgalactic mist: the implications of cloud sizes in galactic winds and haloes
Authors: Liang Cameron J , Remming Ian 
Published: December 2019

ABSTRACT
Ubiquitous detections of cold/warm gas around galaxies indicate that the circumgalactic medium (CGM) is multiphase and dynamic. Recent state-of-the-art cosmological galaxy simulations have generally underproduced the column density of cold halo gas. We argue that this may be due to a mismatch of spatial resolution in the circumgalactic space and the relevant physical scales at which the cold gas operates. Using semi-analytic calculations and a set of magnetohydrodynamic simulations, we present a multiphase model of the gaseous haloes around galaxies, the circumgalactic mist (CGmist). The CGmist model is based on the idea that the observed cold halo gas may be a composite of cold, dense, and small cloudlets embedded in a hot diffuse halo, resembling terrestrial clouds and mist. We show that the resulting cold gas from thermal instabilities conforms to a characteristic column density of $N_{\rm H}\approx 10^{17}\, \rm {cm^{-2}}$ as predicted by the cstcool ansatz. The model implies a large number of cold clumps in the inner galactic halo with a small volume filling factor but a large covering fraction. The model also naturally gives rise to spatial extents and differential covering fractions of cold, warm, and hot gas. To self-consistently model the co-evolution of the CGM and star formation within galaxies, future simulations must address the mismatch of the spatial resolution and characteristic scale of cold gas.
Asteroid masses obtained with INPOP planetary ephemerides
Authors: Fienga A , Avdellidou C , Hanuš J 
Published: December 2019

ABSTRACT
In this paper, we present masses of 103 asteroids deduced from their perturbations on the orbits of the inner planets, in particular Mars and the Earth. These determinations and the INPOP19a planetary ephemerides are improved by the recent Mars orbiter navigation data and the updated orbit of Jupiter based on the Juno mission data. More realistic mass estimates are computed by a new method based on random Monte Carlo sampling that uses up-to-date knowledge of asteroid bulk densities. We provide masses with uncertainties better than 33${{\ \rm per\ cent}}$ for 103 asteroids. Deduced bulk densities are consistent with those observed within the main spectroscopic complexes.
Global simulations of galactic discs: violent feedback from clustered supernovae during bursts of star formation
Authors: Martizzi Davide 
Published: December 2019

ABSTRACT
A suite of idealized, global, gravitationally unstable, star-forming galactic disc simulations with 2 pc spatial resolution, performed with the adaptive mesh refinement code ramses, is used in this paper to predict the emergent effects of supernova feedback. The simulations include a simplified prescription for the formation of single stellar populations of mass $\sim 100 \, {\rm M}_{\odot }$, radiative cooling, photoelectric heating, an external gravitational potential for a dark matter halo and an old stellar disc, self-gravity, and a novel implementation of supernova feedback. The results of these simulations show that gravitationally unstable discs can generate violent supersonic winds with mass-loading factors η ≳ 10, followed by a galactic fountain phase. These violent winds are generated by highly clustered supernovae exploding in dense environments created by gravitational instability, and they are not produced in simulation without self-gravity. The violent winds significantly perturb the vertical structure of the disc, which is later re-established during the galactic fountain phase. Gas resettles into a quasi-steady, highly turbulent disc with volume-weighted velocity dispersion $\sigma \gt 50 \, {\rm km\, s}^{-1}$. The new configuration drives weaker galactic winds with a mass-loading factor η ≤ 0.1. The whole cycle takes place in ≤10 dynamical times. Such high time variability needs to be taken into account when interpreting observations of galactic winds from starburst and post-starburst galaxies.
Music Therapists’ Goal and Objective Writing Practices
Authors: Abbott Elaine A 
Published: December 2019

Abstract
Maintaining current curricular materials for teaching goal and objective writing can be challenging. The purpose of the present study was to investigate the goal and objective writing practices of music therapists and compare them to the related music therapy literature. A survey was emailed to 6,643 board-certified music therapists asking them to describe their goal and objective writing and to share examples of such statements. Four hundred fifty-seven music therapists responded. Quantitative analysis of the results revealed that the majority of respondents participated in writing goals and objectives as well as nine other types of related statements. Qualitative analysis of the statement examples revealed that the statements were constructed using 15 different components. Comparison of study results and published literature demonstrate alignment with current practice in the descriptions it provides of the basic qualities of goal and objective statements. Data analysis also indicates that current practice encompasses a larger scope and complexity of ideas than those presented in the literature. Clinical and educational implications are discussed.
Spatially multiplexed RNA in situ hybridization to reveal tumor heterogeneity
Authors: Voith von Voithenberg Lena , Fomitcheva Khartchenko Anna , Huber Deborah , Schraml Peter , Kaigala Govind V 
Published: December 2019

AbstractMultiplexed RNA in situ hybridization for the analysis of gene expression patterns plays an important role in investigating development and disease. Here, we present a method for multiplexed RNA-ISH to detect spatial tumor heterogeneity in tissue sections. We made use of a microfluidic chip to deliver ISH-probes locally to regions of a few hundred micrometers over time periods of tens of minutes. This spatial multiplexing method can be combined with ISH-approaches based on signal amplification, with bright field detection and with the commonly used format of formalin-fixed paraffin-embedded tissue sections. By using this method, we analyzed the expression of HER2 with internal positive and negative controls (ActB, dapB) as well as predictive biomarker panels (ER, PgR, HER2) in a spatially multiplexed manner on single mammary carcinoma sections. We further demonstrated the applicability of the technique for subtype differentiation in breast cancer. Local analysis of HER2 revealed medium to high spatial heterogeneity of gene expression (Cohen effect size r = 0.4) in equivocally tested tumor tissues. Thereby, we exemplify the importance of using such a complementary approach for the analysis of spatial heterogeneity, in particular for equivocally tested tumor samples. As the method is compatible with a range of ISH approaches and tissue samples, it has the potential to find broad applicability in the context of molecular analysis of human diseases.
Scalable and cost-effective ribonuclease-based rRNA depletion for transcriptomics
Authors: Huang Yiming , Sheth Ravi U , Kaufman Andrew , Wang Harris H 
Published: December 2019

Abstract
Bacterial RNA sequencing (RNA-seq) is a powerful approach for quantitatively delineating the global transcriptional profiles of microbes in order to gain deeper understanding of their physiology and function. Cost-effective bacterial RNA-seq requires efficient physical removal of ribosomal RNA (rRNA), which otherwise dominates transcriptomic reads. However, current methods to effectively deplete rRNA of diverse non-model bacterial species are lacking. Here, we describe a probe and ribonuclease based strategy for bacterial rRNA removal. We implemented the method using either chemically synthesized oligonucleotides or amplicon-based single-stranded DNA probes and validated the technique on three novel gut microbiota isolates from three distinct phyla. We further showed that different probe sets can be used on closely related species. We provide a detailed methods protocol, probe sets for &gt;5000 common microbes from RefSeq, and an online tool to generate custom probe libraries. This approach lays the groundwork for large-scale and cost-effective bacterial transcriptomics studies.
Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes
Authors: Liang Xue-hai , Sun Hong , Hsu Chih-Wei , Nichols Joshua G , Vickers Timothy A , De Hoyos Cheryl L , Crooke Stanley T 
Published: December 2019

AbstractRelease of phosphorothioate antisense oligonucleotides (PS-ASOs) from late endosomes (LEs) is a rate-limiting step and a poorly defined process for productive intracellular ASO drug delivery. Here, we examined the role of Golgi-endosome transport, specifically M6PR shuttling mediated by GCC2, in PS-ASO trafficking and activity. We found that reduction in cellular levels of GCC2 or M6PR impaired PS-ASO release from endosomes and decreased PS-ASO activity in human cells. GCC2 relocated to LEs upon PS-ASO treatment, and M6PR also co-localized with PS-ASOs in LEs or on LE membranes. These proteins act through the same pathway to influence PS-ASO activity, with GCC2 action preceding that of M6PR. Our data indicate that M6PR binds PS-ASOs and facilitates their vesicular escape. The co-localization of M6PR and of GCC2 with ASOs is influenced by the PS modifications, which have been shown to enhance the affinity of ASOs for proteins, suggesting that localization of these proteins to LEs is mediated by ASO-protein interactions. Reduction of M6PR levels also decreased PS-ASO activity in mouse cells and in livers of mice treated subcutaneously with PS-ASO, indicating a conserved mechanism. Together, these results demonstrate that the transport machinery between LE and Golgi facilitates PS-ASO release.
Small Police Agency Use of Social Media: Positive and Negative Outcomes Noted in a Case Study
Authors: Hu Xiaochen , Lovrich Nicholas P 
Published: December 2019

AbstractMany studies on police use of social media focus on large police agencies. The current case study investigates how a rather small police agency has attracted broad attention on ‘Facebook’. By selecting a relatively small police agency that received a great many Facebook ‘likes’, the study investigates two social media-centered questions: (1) What are this police agency’s strategies of engaging so many citizens on Facebook? and (2) what are potential risks related to these strategies? Findings suggest that two major strategies were used to achieve such uncommon ‘subscriber success’ on Facebook: (1) maintaining the department’s Facebook page as a personal account page directed towards a Chief’s or Sheriff’s own philosophy of policing and (2) writing Facebook posts in a folksy vernacular featuring slang terms and relating humorous (often suspect deprecating) stories using such language. The current study proposes that law enforcement agencies may use informal communication to engage citizens, but they also need a formal team to give consistency and avoid dependency on a single person regarding managing their Facebook accounts. Burgoon’s (1978) expectancy violations theory is used to help explain both the positive and negative outcomes noted in the current study. The principal public policy implications regarding social media use by police agencies are discussed, along with implications for further research.
Do Fund Managers Misestimate Climatic Disaster Risk
Authors: Alok Shashwat , Kumar Nitin , Wermers Russ 
Published: December 2019

Abstract
We examine whether professional money managers overreact to large climatic disasters. We find that managers within a major disaster region underweight disaster zone stocks to a much greater degree than distant managers and that this aversion to disaster zone stocks is related to a salience bias that decreases over time and distance from the disaster, rather than to superior information possessed by close managers. This overreaction can be costly to fund investors for some especially salient disasters like hurricanes and tornadoes: a long-short strategy that exploits the overreaction generates a significant DGTW-adjusted return over the following 2 years.
Clinicopathologic analysis of 722 breast cancer patients who met the inclusion criteria of the TAILORx trial
Authors: Xiang Hong-Yu , Liu Yin-Hua , Zhang Hong , Zhang Shuang , Xin Ling , Xu Ling , Ye Jing-Ming , Li Ting , Duan Xue-Ning , Liu Qian 
Published: December 2019

Abstract

Background:
The results of the Trial Assigning IndividuaLized Options for Treatment (TAILORx) suggested that approximately 70% of T1-2N0M0, hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients can avoid chemotherapy and receive only adjuvant endocrine therapy. We conducted a retrospective analysis of the clinicopathologic features and prognostic factors of patients with breast cancer who met the inclusion criteria of the TAILORx trial.

Methods:
According to the enrollment criteria of the TAILORx trial, a retrospective analysis was performed on patients with breast cancer who were treated from January 2008 to December 2015 at Peking University First Hospital. The clinicopathologic characteristics of all patients were analyzed, and prognoses were calculated using the Kaplan-Meier method and a Cox proportionate hazards model.

Results:
A total of 2430 patients with early stage breast cancer who were admitted at our hospital had complete clinicopathologic data and follow-up information. Of these patients, 722 met the inclusion criteria and were enrolled in the present study, accounting for 29.7% of all patients. Among them, 417 (57.8%) patients received only adjuvant endocrine therapy (the non-chemo group), and 305 (42.2%) patients received adjuvant chemotherapy followed by adjuvant endocrine therapy (the chemo group). No statistically significant difference was observed in overall survival (OS) between the two groups (non-chemo vs. chemo: 5-year OS: 97.9% vs. 97.9%, χ
2 = 1.00, P = 0.995; hazard ratio [HR] = 1.00, 95% confidence interval [CI]: 0.46–2.21). A significant difference was observed in disease-free survival (DFS) between the two groups (non-chemo vs. chemo: 5-year DFS: 97.9% vs. 94.7%, χ
2 = 8.65, P = 0.003; HR = 3.05, 95% CI: 1.40–6.67). The choice of adjuvant therapy was associated with clinicopathologic factors, such as the age at diagnosis, T stage, histologic grade, the Ki67 index, the presence of intravascular tumor thrombus (P < 0.001), pathologic type, and menstrual status (P = 0.014).

Conclusions:
In the absence of internationally recognized multigene testing methods, for patients with early hormone receptor-positive, HER2-negative breast cancer, clinicians can develop a treatment plan based on clinicopathologic features only, which can effectively screen some patients who do not need adjuvant chemotherapy. However, nearly half of patients still receive adjuvant chemotherapy, and whether these patients can be exempted from chemotherapy warrants further exploration.
Trends in computed tomography scan uses in Taiwan from 2000 to 2013
Authors: Hsueh Yung-Wei , Lin You-Cheng , Lin Ching-Heng , Chen Hung-Chieh , Huang Zheng-Yi , Chai Jyh-Wen , Chen Clayton Chi-Chang 
Published: December 2019

Background:
The trends in computed tomography (CT) scan uses in Taiwan were examined in different age and sex groups and compared between catastrophic illness and noncatastrophic illness groups.

Methods:
This retrospective cohort study used data from the National Health Insurance Research Database (NHIRD) in Taiwan to analyze CT scan uses from the beginning of 2000 to the end of 2013. The number, annual growth rate, and cumulative fold change ratio were estimated in different groups classified by sex, age, or disease category (catastrophic illness, noncatastrophic illness).

Results:
The number of CT scan uses per million people per year in Taiwan increased 2.5 times from 24 257 in 2000 to 60 351 in 2013, at the average annual growth rate of 7.4% ± 5.9%. The annual number of CT scan uses in different age groups and disease category groups was significantly higher in males than in females. However, the average annual growth rate and the cumulative fold change ratio were slightly higher in females than in males. The majority of CT scan uses were in middle age and young adult groups. The annual number of CT scan uses in the young adult, child/adolescent, and middle age groups increased 3.7-, 3.5-, and 2.7-fold from 2000 to 2013, but decreased 0.8-fold in the old-age group. The annual number of CT scan uses was highest in the noncatastrophic illness group, followed by the catastrophic illness cancer group and catastrophic illness others group.

Conclusion:
CT scan uses in Taiwan increased continuously from 2000 to 2013, even in the groups with higher radiation-related cancer risk. Therefore, clinicians, radiologists, and medical policy makers should weigh diagnostic benefit against sex-specific and age-specific risks in the future.
Hypertonic saline versus mannitol for the treatment of increased intracranial pressure in traumatic brain injury
Authors: DeNett, Taylor , Feltner, Cassandra 
Published: December 2019

ABSTRACT

Background:
Increased intracranial pressure (ICP) occurring after traumatic brain injury (TBI) is associated with increased morbidity and mortality. If appropriate treatments are not initiated, brain herniation can occur and lead to death. Previously, the Brain Trauma Foundation recommended mannitol as the first-choice hyperosmolar agent. However, in 2016, they retracted this recommendation, citing a lack of sufficient supporting evidence. Current research shows that hypertonic saline (HTS) also decreases ICP.

Objectives:
To compare the efficacy of HTS and mannitol in lowering ICP in patients with TBI.

Data sources:
A search was conducted up to June 1, 2019, using PubMed, Embase, CINAHL, and Web of Science. Selected articles compared mannitol and HTS in adults with TBI, with the measured outcome of reduced ICP. Four meta-analyses, three randomized controlled trials, and one retrospective cohort study met the inclusion criteria.

Conclusions:
Hypertonic saline is an effective alternative to mannitol for increased ICP. Three studies suggested HTS may be superior to mannitol. Conclusions were limited by sample size and methodological differences, such as varying concentrations and doses, and inclusion of patients without TBI in their studies.

Implications for practice:
Evidence demonstrates HTS to be as effective as mannitol for ICP reduction. Further research in a large multicenter clinical trial is needed to compare these two agents for superiority in the management of increased ICP. Providers should consider the properties of each agent, adverse effects, and potential benefits when selecting a hyperosmotic agent.
State of clinical pain research in Nepal: a systematic scoping review
Authors: Sharma Saurab , Jensen Mark P. , Pathak Anupa , Sharma Sweekriti , Pokharel Mukesh , Abbott J. Haxby 
Published: December 2019

AbstractBefore determining the pain research priorities for a country, a comprehensive literature review of existing research is warranted. We aimed to (1) identify and describe the extent and nature of pain research performed in Nepal, (2) identify existing knowledge and significant knowledge gaps, and (3) provide recommendations for future studies. We conducted a systematic scoping review of the literature, in accordance with recommended guidelines. We searched local and international databases to identify research conducted in Nepal on individuals with a diagnosis of clinical pain conditions. A pair of independent reviewers screened the studies for inclusion. We identified 1396 records and included 116 studies. Most studies were published in Nepalese journals (75%) and were conducted in clinical settings (73%). Postsurgical pain was the most commonly studied pain condition (33%), followed by musculoskeletal pain (16%), headache (14%), and low back pain (13%). The most common research topics, in order of frequency, were (1) medical management (40%), (2) pain prevalence/incidence (21%), (3) diagnostic procedures (15%), (4) surgical management (8%), and (5) patient-reported outcome measurement (8%). Research gaps and potential areas of research waste were identified. Although a large number of research articles about pain in Nepal have been published, the majority of these have focused on the biomedical diagnosis and management of pain. Other topic areas (eg, psychological and social aspects of pain) are under-represented. The findings may inform future research directions for maximizing the knowledge that could be gained.