bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and application of magnetized nanoparticles to remove lead from drinking water: Taguchi design of experiment
Authors: Jalees Muhammad Irfan 
Published: January 2020

Abstract
Contamination in drinking water from heavy metals like Pb2+ has severe effects on health. In this study, potato peel (PP) was used as the substrate and magnetic iron nanoparticles (MI) were deposited on PP using a co-precipitated method. Fourier transformation infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis confirmed the deposition of MI on PP. The L16 (4^4) method of Taguchi design of experiment (DOE) was used for the optimization of adsorption condition, i.e., at 6 pH, 10 min of contact time, and a dose of 15 g/L can give more than 90% removal efficiency of Pb2+ using PP-MI. Contour maps, Taguchi response analysis, and analysis of variance (ANOVA) suggested that pH has a dominant contribution in the removal of Pb2+. The adsorption process was favorable, spontaneous, and exothermic in nature and was followed by pseudo second order kinetics. A comparison of the sorption capacity of PP-MI for Pb2+ with literature values suggested that PP-MI has good potential for the removal of Pb2+.
This article has been made Open Access thanks to the generous support of a global network of libraries as part of the Knowledge Unlatched Select initiative.
Biofilme a partir de gelatina e glicerol com a adição de íons de prata como agente antimicrobiano
Authors: Leite Inacio de sá , Pinto Jr Wilson Rodrigues , SILVA LEONARDO DE ARAÚJO 
Published: January 2020

O interesse por embalagens biodegradáveis tais como os bioplásticos está aumentando porque o uso de materiais e recursos renováveis contribui para a preservação ambiental. Entre todos os biopolímeros, a gelatina está sendo pesquisada como um material com grande potencial para elaboração de filmes biodegradáveis. O objetivo deste estudo foi à elaboração de um biofilme de gelatina e glicerol com propriedade antibacteriana. O bioplástico formulado na proporção 1:1 (16% de gelatina e 16% de glicerol) apresentou aspecto homogêneo, transparente, com ausência de bolhas na superfície e boa flexibilidade (facilidade de manuseio e ausência de rupturas e zonas quebradiças). O filme apresentou total solubilidade em ácido clorídrico 1N e a análise de biodegradabilidade indicou uma perda de massa total durante 30 dias enterrados no solo. A solução de íons de prata teve um efeito bactericida, com base na concentração inibitória mínima (1 mg. mL-1, 0,5 mg. mL-1, 0,25 mg. mL-1) testada, frente ao microrganismo Escherichia colli ATCC 25922. Esse efeito continuou presente quando os íons de prata (1 mg. mL-1) foram adicionados no biofilme, visto que para todos os filmes testados foram observados halos de inibição maiores ou iguais a 30 mm. Os resultados apontam perspectivas da utilização do biofilme formulado a base de gelatina com adição de íons de prata na categoria de embalagens ativas.
Deciphering the Nature of Caffeic Acid to Inhibit the HSA Aggregation Induced by Glyoxal
Authors: Bhat Waseem Feeroze , Ahmed Azaj , Abbass Shabeena , Afsar Mohammad , Bano Bilqees , Masood Akbar 
Published: January 2020

Background:
Under certain circumstances, the path for protein folding deviates and
attains an alternative path forming misfolded states, which are the key precursors for protein
aggregation. Protein aggregation is associated with variety of diseases and leads to the cytotoxicity.
These protein aggregate related diseases have been untreated so far. However, extensive attempts
have been applied to develop anti-aggregating agents as possible approaches to overcome protein
aggregation. Different types of substances have been reported to halt or decrease the formation of
ordered protein aggregates both in vitro and in vivo, such as polyphenols and metal ions.

Objective:
In the present study the in vitro aggregation of human serum albumin (HSA) by using a
reactive dicarbonyl glyoxal has been investigated, simultaneously an attempt has been done to
inhibit the glyoxal (GO) induced aggregation of (HSA) by caffeic acid (CA).

Methods:
Different methods have been employed to investigate the process, fluorescence
spectroscopy, circular dichroism, cango red binding assay, thioflavin T dye binding, turbidimetric
analysis, docking study and transmission electron microscopy.

Results:
Results have shown that elevated concentration of GO forms aggregates of HSA, and the
activity of CA suggested the possibility of inhibiting the HSA aggregation at higher concentrations,
and this compound was found to have an anti-aggregation property.

Conclusion:
The present study explained that micro molar concentrations of CA inhibits the
aggregation of HSA and showed pronounced anti-aggregation effect at increasing concentrations in
the presence of GO which is elevated in diabetic and hyperglycaemia conditions.
In Silico Elucidation of the Plausible Inhibitory Potential of Withaferin A of Withania Somnifera Medicinal Herb Against Breast Cancer Targeting Estrogen Receptor
Authors: Ali Mohammad A. , Farah Mohammad Abul , Al-Anazi Khalid M. , Basha Syed H. , Bai Fang , Lee Joongku , Al-Hemaid Fahad M.A. , Mahmoud Ahmed H. , Hailan Waleed A.Q. 
Published: January 2020

Background:
Estrogen Receptors (ER) are members of the nuclear intracellular receptors
family. ER once activated by estrogen, it binds to DNA via translocating into the nucleus and regulates
the activity of various genes. Withaferin A (WA) - an active compound of a medicinal plant Withania
somnifera was reported to be a very effective anti-cancer agent and some of the recent studies has
demonstrated that WA is capable of arresting the development of breast cancer via targeting estrogen
receptor.

Objective:
The present study is aimed at understanding the molecular level interactions of ER and Tamoxifen
in comparison to Withaferin A using In-silico approaches with emphasis on Withaferin A
binding capability with ER in presence of point mutations which are causing de novo drug resistance to
existing drugs like Tamoxifen.

Methods:
Molecular modeling and docking studies were performed for the Tamoxifen and Withaferin
A with the Estrogen receptor. Molecular docking simulations of estrogen receptor in complex with
Tamoxifen and Withaferin A were also performed.

Results:
Amino acid residues, Glu353, Arg394 and Leu387 was observed as crucial for binding and
stabilizing the protein-ligand complex in case of Tamoxifen and Withaferin-A. The potential of
Withaferin A to overcome the drug resistance caused by the mutations in estrogen receptor to the existing
drugs such as Tamoxifen was demonstrated.

Conclusion:
In-silico analysis has elucidated the binding mode and molecular level interactions which
are expected to be of great help in further optimizing Withaferin A or design / discovery of future
breast cancer inhibitors targeting estrogen receptor.
Gelatin and Glycerine-Based Bioadhesive Vaginal Hydrogel
Authors: Cassano Roberta , Curcio Federica , Mandracchia Delia , Trapani Adriana , Trombino Sonia 
Published: January 2020

Aim:
The work’s aim was the preparation and characterization of a hydrogel based on gelatin
and glycerine, useful for site-specific release of benzydamine, an anti-inflammatory drug, able to attenuate
the inflammatory process typical of the vaginal infection.

Objective:
The obtained hydrogel has been characterized by Electronic Scanning Microscopy (SEM)
and Differential Scanning Calorimetry (DSC). In addition, due to the precursor properties, the hydrogel
exhibits a relevant mucoadhesive activity.

Methods:
The swelling degree was evaluated at two different pHs and at defined time intervals. In particular,
phosphate buffers were used at pH 6.6, in order to mimic the typical conditions of infectious
diseases at the vaginal level, particularly for HIV-seropositive pregnant women, and pH 4.6, to simulate
the physiological environment.

Results:
The obtained results revealed that the hydrogel swells up well at both pHs.

Conclusion:
Release studies conducted at both pathological and physiological pHs have shown that
benzydamine is released at the level of the vaginal mucosa in a slow and gradual manner. These data
support the hypothesis of the hydrogel use for the site-specific release of benzydamine in the vaginal
mucosa.
Preliminary Analysis of Anti-proliferative, Apoptotic, and Anti-migratory Effects llw-3-6 in Skov-3 Ovarian Cystadenocarcinoma Cell Line
Authors: Gregory-Bass Rosalind , Winfield Leyte L. 
Published: January 2020

Background:
Ovarian cancer and ovarian related diseases affect reproductive health.
Therapeutic molecules are needed to improve treatment outcomes and overcome drug resistance.
The benzimidazole-based sulphonamide LLW-3-6 has both anti-apoptotic and anti-proliferative
effects when used to treat prostate, breast, and brain cancer cells.

Objective:
The study described herein evaluates the anti-proliferative and anti-migratory effects of
LLW-3-6 in SKOV-3 ovarian cystadenocarcinoma cell line.

Methods:
Studies were conducted using SKOV-3 cells treated with LLW-3-6. The cell line was
propagated and proliferative activity was evaluated by hemocytometric and MTT colorimetric
assays. Cellular apoptosis was assessed using caspase-3 spectrophotometric analysis. Lastly, a
scratch wound assay was conducted at several concentrations and time points to assess the effect of
LLW-3-6 on migration.

Results & Conclusion:
Proliferative studies suggest, SKOV-3 cells exposed to LLW-3-6 in culture
resulted in decreased growth and proliferation of cells in a time and dose-dependent manner. The
apoptotic effect of this agent was noted with the confirmed presence of Caspase-3 in a dose and
time-dependent manner as well. Preliminary studies also suggest an anti-migratory effect of LLW-3-
6, confirmed by scratch wound analysis.

Conclusion:
LLW-3-6 is potentially a chemotherapeutic option for decreasing proliferation and
inducing apoptosis in ovarian carcinomas. Additional biological analysis are ongoing to further
assess the utility of the molecule and its mechanism of action.
Characterization of Antimicrobial Resistance Patterns of Klebsiella pneumoniae Isolates Obtained from Wound Infections
Authors: Ghanavati Roya , Kazemian Hossein , Asadollahi Parisa , Heidari Hamid , Irajian Gholamreza , Navab-Moghadam Fatemeh , Razavi Shabnam 
Published: January 2020

Background:
Multidrug resistance among ESBL producing isolates has limited the administration
of proper antibiotics. It is, therefore, important to monitor the resistance patterns of
Klebsiella pneumoniae isolates and provide infection control strategies to prevent nosocomial outbreaks.
This study was aimed to determine antimicrobial resistance patterns of K. pneumoniae isolates
obtained from wound infections of patients in Tehran, Iran.

Methods:
A total of 102 K. pneumoniae isolates were obtained from wound infections of patients
in Tehran, Iran. The production of phenotypic ESBL and carbapenemase was assessed using the
double-disc synergy test (DDST) and modified Hodge test (MHT), respectively. PCR was performed
for the detection of ESBL, carbapenemase, quinolone and aminoglycoside resistance genes.

Results:
Forty-six (45.1%) and 23 (22.5%) isolates, out of the 102 isolates, were phenotypically detected
as ESBL and carbapenemase producers, respectively. The PCR results showed that 80/102
(78.4%) and 51/102 (50%) isolates possessed at least one of the assessed ESBL and carbapenemase
genes, respectively. Quinolone resistance determinants (QRDs) and aac(6')-Ib genes were
found amongst 50 (49%) and 67 (65.7%) isolates, respectively. Four isolates carried blaTEM, blaSHV,
blaCTX-M, qnrB, qnrS and aac(6’)-Ib genes, simultaneously.

Conclusion:
Due to the presence of multiple resistance genes among some K. pneumoniae strains,
antibiotic agents should be used with caution to preserve their efficacy in case of life-threatening infections.
Neovascular Age-Related Macular Degeneration and its Association with Alzheimer’s Disease
Authors: Papadopoulos Zois 
Published: January 2020

:
In developed countries, people of advanced age go permanently blind most often due to
age-related macular degeneration, while at the global level, this disease is the third major cause of
blindness, after cataract and glaucoma, according to the World Health Organisation. The number of
individuals believed to suffer from the disease throughout the world has been approximated at 50
million. Age-related macular degeneration is classified as non-neovascular (dry, non-exudative)
and neovascular (wet, exudative). The exudative form is less common than the non-exudative as it
accounts for approximately 10 percent of the cases of the disease. However, it can be much more
aggressive and could result in a rapid and severe loss of central vision. Similarly, with age-related
macular degeneration, Alzheimer’s disease is a late-onset, neurodegenerative disease affecting millions
of people worldwide. Both of them are associated with age and share several features, including
the presence of abnormal extracellular deposits associated with neuronal degeneration, drusen,
and plaques, respectively. The present review article highlights the pathogenesis, clinical features,
and imaging modalities used for the diagnosis of neovascular age-related macular degeneration. A
thorough overview of the effectiveness of anti-VEGF agents as well as of other treatment modalities
that have either lost favour or, are rarely used, is provided in detail. Additionally, the common
histologic, immunologic, and pathogenetic features of Alzheimer’s disease and age-related macular
degeneration are discussed in depth.
The Effect of Grain Size on Microwave Interaction of Magnetite Concentrate Mixed with Carbonized Biomass Waste
Authors: Öztürk Elif Aranci , Boyrazli Mustafa , Turan Mehmet Deniz , Erdemoğlu Murat 
Published: January 2020

Aims:
In this study, microwave interaction of magnetite ore concentrate which
was mixed with carbonized biomass waste and divided into different grain sizes, was
studied.

Materials and Methods:
The mixture consisting of magnetite concentrate and carbonized
product was pelletized by the addition of molasses and jelly as binders. The pellets prepared
with various particle size powders were subjected to microwave treatment at different
times.

Results:
emperature of the pellet produced with powders between -212 +150 μm grain
sizes and -45 μm were measured as 837.5°C at 304th second and 945.9°C at 210th second
respectively.

Conclusion:
Although there was a large temperature difference between the core and the
surface of the pellet, a high degree of metallization was observed in these samples.
Amelioration of Dementia and Antioxidant Activity of Holarrhena antidysenterica Bark in Mice
Authors: Kaur Jasleen , Kumar Manish , Bansal Nitin 
Published: January 2020

Background:
Holarrhena antidysenterica is a deciduous shrub/small-tree having
bioactive alkaloids such as conessine, known for astringent, antidysenteric, anthelmintic,
stomachic, febrifugal, tonic and anti-acetylcholinesterase properties. Dementia is an
age related neurodegenerative syndrome with Alzheimer’s disease, the most prominent
cause, which has limited therapeutic options available.

Objective:
The present study aimed to explore the potential benefits of H. antidysenterica
in the management of dementia.

Method:
Aqueous and methanol extracts of powdered bark of H. antidysenterica were
prepared, concentrated and conessine concentration was estimated using High Performance
Thin Layer Chromatography (HPTLC) method. Methanol extract of H. antidysenterica
(MEHA) was administered at doses 100, 150 and 200 mg/kg (i.p.) to mice (20-30 g) for 14
consecutive days. Scopolamine (Scop; 1 mg/kg) and Lipopolysaccharide (LPS; 250 μg/kg)
were given (i.p.) before behavioural trials to induce memory impairment. Learning and
memory functions in mice were evaluated. Brain acetylcholinesterase (AChE) activity,
glutathione (GSH) and Thiobarbituric Acid Reactive substances (TBARS) levels were estimated.

Results:
MEHA markedly increased learning and memory of mice. Scop or LPS caused a
significant decline of spatial memory in mice, which was attenuated by MEHA (100 and
200 mg/kg). Furthermore, LPS conspicuously increased the lipid peroxidation and compromised
antioxidant levels in mice brains. MEHA pre-treatment significantly increased
GSH content and decreased TBARS level in the brain of LPS administered mice. AChE
activity was significantly decreased by MEHA in the brain of mice.

Conclusion:
The methanol extract of H. antidysenterica may prove to be a useful remedy
in the management of dementia.
K-means Clustering-based Radio Neutron Star Pulsar Emission Mechanism
Authors: Shrimali Shubham , Pandey Amritanshu , Chowdhary Chiranji L. 
Published: January 2020

Aim:
The aim of this paper is to work on K-means clustering-based radio neutron star
pulsar emission mechanism.

Background:
The pulsars are a rare type of neutron stars that produce radio rays. Such types of
rays are detectable on earth and have attracted scientists because of their concern with space-time,
interstellar medium, and states of matter. During the rotation of pulsar rays, rays are emitted in the
whole sky and after crossing the threshold value, the pattern of radio emission broadband is detected.
As rotation speed of pulsar increases then accordingly the types of the patterns are produced
periodically. Every pulsar emits different patterns that are a little bit different from each
other which fully depends on its rotation. The detected signals are known as a candidates. It can be
determined by the length of observation and it is average of all the rotations of the pulsar.

Objective:
The main objectives of this radio neutron star pulsar emission mechanism are: (a) Decision
Tree Classifier (2) K-means Clustering (3) Neural Networks.

Methods:
The Pulsar Emission Data was broken down into two sets of data: Training Data and
Testing Data. The Training Data is used to train the Decision Tree, the algorithm, K-means clustering
and Neural Networks to allow it to identify, which attributes (Training Labels) are useful for
identification of Neutron Pulsar Emissions.

Results:
The analysis used multiple machine learning algorithms. It was concluded that using neural
networks is the best possible method to detect pulsar emissions from neutron stars. The best result
achieved was 98% using Neural Networks.

Conclusion:
There are so many benefits of pulsar rays in different technologies. Earth can detect
pulsar ray from low orbit. Earth can completely absorb X-ray in the atmosphere and due to this
reason we can say that the wavelength is limited to those who do not have an atmosphere like
space. According to our result, it can be concluded that the algorithm can be successfully used for
detecting the pulsar signals.
An Intelligent Ranking Model for Multi-Criteria Decision Making Using Fuzzy Matrix Method
Authors: Dahiya Naveen , Sangwan Pardeep 
Published: January 2020

Background:
In the daily life, one may encounter several problems whose solution is based on the
consideration of several criteria altogether. To generate a solution for such problems is in fact a complex task. If
one generates a solution, then there is no guarantee that the solution is optimal. It is really challenging to take
into account all the criteria at the same time and generate a solution that is optimal. Several techniques have been
proposed to solve multi-criteria decision making problems.

Methods:
In this paper, we propose an intelligent solution to multi criteria decision making problem by means
of fuzzy aggregation using matrix method. The proposed method finds application in solving such problems
where the criteria are defined in qualitative form (fuzzy linguistic variables) rather than in quantitative form
(crisp). A novel application of the proposed approach to rank the employees in an organization is presented in
the paper.

Results:
The proposed method is empirically validated by applying it to find the best employee in a institute of
repute. Data collection is done in real time to prove the utilization of proposed approach in a efficient manner.

Conclusion:
The results obtained after application of proposed method to rank the employees are realistic as it
takes into consideration the ambiguity involved in human thought process.
Kajian Magnetoresistansi pada Nanopartikel Magnetite (Fe3o4) yang Dienkapsulasi dengan Polyethylene Glycole (PEG) dan Biomaterial dengan Sensor Lapisan Tipis Co/Cu Multilayer Berbasis Giant Magnetoresistance (GMR) (Halaman 13 s.d. 19)
Authors: Artauli Hasibuan1 Ferawati , Pardede Indra , Suharyadi Edi 
Published: January 2020

Telah dilakukan kajian magnetoresistansi (MR) pada nanopartikel magnetit (Fe3O4) yang dienkapsulasi dengan poliethilen glikol (PEG)-4000 dan biomolekul menggunakan sensor lapisan tipis berbasis giant magnetoresistance (GMR). Lapisan tipis yang digunakan adalah Si/Cr(5nm)/[Co(1,5nm)/Cu(x)]20/Cr(5nm) multilayer (x = 0,8; 0,9; dan 1,0 nm). Fenomena GMR dipengaruhi oleh variasi ketebalan lapisan tipis dan pelapisan nanopartikel Fe3O4 yang dienkapsulasi dengan PEG dan penambahan biomolekul yang mengganggu mobilitas momen magnetik material. Resistansi pada ketebalan lapisan tipis Cu 0,8; 0,9; dan 1,0 nm ketika H=0 masing-masing 3,7; 3,5; dan 2,7 Ohm dan ketika H=599,7 G masing-masing 3,5; 3,2; dan 2,3 Ohm. Nilai MR ketika lapisan tipis dilapisi nanopartikel Fe3O4, Fe3O4 yang dienkapsulasi dengan PEG, dan Fe3O4 yang dienkapsulasi dengan PEG dan penambahan biomolekul masing-masing mengalami perubahan yang berbeda. Perubahan nilai MR pada lapisan tipis multilayer sebelum dan setelah pelapisan nanopartikel menunjukkan bahwa lapisan tipis Co/Cu multilayer dapat diaplikasikan sebagai sensor medan magnet dan potensial sebagai biosensor.
Pengembangan Pendingin Termoakustik dengan Menggunakan Penukar Kalor Tambahan dalam Resonator (Halaman 59 s.d. 63)
Authors: P. Asmara , A. Pebriarti , I. Setiawan , Bambang S.U. Agung 
Published: January 2020

Telah dilakukan penelitian piranti termoakustik dengan mengamati pengaruh heat exchanger menggunakan berbagai debit cairan dan jenis cairan pada penurunan suhu tandon panas dan tandon dingin. Hasil yang diperoleh sebagai cairan terbaik yang digunakan adalah air, disamping mudah didapat juga tidak menimbulkan korosi pada pipa tembaga sehingga aliran cairan dalam pipa berjalan dengan lancar dan diperoleh penurunan suhu pada tandon panas sebesar 5,5 °C serta 1,3 °C pada tandon dingin. Adapun penurunan suhu optimum tandon panas sebesar 5,4 °C dan tandon dingin sebesar 1,8 °Cyang terjadi pada saat pipa tembaga dialiri air dengan debit (2,47 ± 0,01) mL/s. Terlihat dengan adanya penggunaan heat exchanger berupa pipa tembaga yang dialiri cairan menyebabkan tandon panas mengalami penurunan suhu sehingga tandon panas belum jenuh dan pemompaan kalor dari tandon dingin ke tandon panas tetap stabil (dingin) yang berarti kinerja sistem meningkat.
Aplikasi Sensor Smartphone dalam Eksperimen Penentuan Percepatan Gravitasi (Halaman 10 s.d. 13)
Authors: Suciarahmat Aan , Pramudya Yudhiakto 
Published: January 2020

Telah dilakukan penelitian untuk menentukan nilai percepatan gravitasi menggunakan aplikasi sensor Smartphone berbasis Android. Analisis matematis dilakukan menggunakan teknik rata-rata dari data yang terekam oleh aplikasi sensor Accelerometer. Analisis data smartphone ini dibandingkan dengan data yang diperoleh dari video analisis program Logger Pro, dan untuk membantu perhitungan dilakukan analisis dengan pendekatan Regresi Linier. Dari hasil analisis data smartphone, diperoleh nilai percepatan gravitasi adalah (9,7245±0,005) m/s2.