bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ventilated slabs: Energy consumption mitigation and thermal comfort augmentation
Authors: Özdenefe Murat , Mousavi Soad Abokhamis , Atikol Uğur 
Published: October 2019

Abstract
This study is an effort to investigate the energy and thermal comfort performance of a ventilated slab application for a particular building type-office building-that is located in Cyprus, which has typical Mediterranean climate with hot dry summers and mild rainy winters. In Cyprus, almost all of the buildings employ reinforced concrete (high thermal mass) for the building frame and slabs. Daytime maximum and night-time minimum temperature difference is substantial, particularly in inland regions of the island during summer time (up to 16 °C). This traditional building structure together with high diurnal temperature difference generates convenient conditions for the application of ventilated slabs. In this work model of an office building, which is incorporated with ventilated slab is simulated with Energy Plus for the Cyprus weather conditions. The results revealed that the ventilated slab system reduced the cooling energy significantly and augmented the thermal comfort. The variation in the ventilated slab hollows’ length and diameter is not effective if the air flow rate is not increased. Thus, the authors suggest to increase the air flow rate through the slab for the best practice.
Development of load calculation algorithm for large space building based on RTS method
Authors: Shim Jisoo , Song Doo-sam 
Published: October 2019

Abstract
Since a large space building has distinguished characteristics, to analyse and predict the peak load these should be considered. The existed building energy simulation cannot reflect the characteristics of large space building, especially vertical temperature distribution. Therefore, to analyse the large space building, it is inevitably used the methods which requires high knowledge skills and economic cost. The goal of this research is suggesting the peak load calculation algorithm for a large space building. With RTS(Radiant Time Series) and simplified model for predicting vertical temperature distribution, the algorithm is expected to show highly applicability with minimum input data and consisted with clear calculation process. The calculation process is composed with three steps. 1) calculation for preparing initial condition, 2) calculation of air movement, 3) calculating peak load for occupied space. With the Energyplus applying airflow network, the result of algorithm is assessed. The predicted temperature and peak load for an occupied zone at each cases are compared. The result applying proposed algorithm shows 33.64 °C at 15 hour and the peak load is 50.92 kW. In case of applying Energy plus, 35.59 °C, 63.93 kW at 16 hour is predicted. For the further research, vertical temperature measurements in large space building will be proceeded. By comparing the measured vertical temperature distribution and predicted temperature in a large space building, the algorithm will be assessed.
Performance evaluation and comparison between rural new and traditional house in severe cold regions of China
Authors: Shao T , Jin H 
Published: October 2019

Abstract
With the development of urban-rural integration, the number of newly built houses is increasing. Due to the influence of climatic characteristics, traditional technology, economy etc, the phenomenon of large heating energy consumption and low indoor thermal comfort in winter is common in rural houses. In order to explore the energy-saving design methods for rural houses in severe cold regions and create a low-carbon and comfortable indoor thermal environment in winter, this paper selects the new house and traditional house of Zhalantun, Inner Mongolia as research objects, applying the methods of testing and calculation to comprehensive comparison of the differences between two types of housing from the aspects of building energy consumption, indoor thermal environment and thermal performance of building envelop. Results show that through the reasonable thermal environment zoning, performance optimization of building envelop and improvement of heating mode etc., the indoor thermal environment can be effectively improved, so as to achieve the purpose of comfort and energy saving.
Thermal analysis in daytime radiative cooling
Authors: Feng Jie , Santamouris Mattheos , Shah Kwok Wei , Ranzi Gianluca 
Published: October 2019

Abstract
Radiative cooling is a well-researched cooling technique which is based on the ability of terrestrial surfaces to dissipate heat to the cold outer space. Past research on radiative cooling mostly failed to present sub-ambient temperature under direct sun due to the limited solar reflectance and emissivity in the atmospheric window. The nanostructures developed in recent years have successfully achieved sub-ambient feature during daytime. This paper mainly presents and analyses the experiment and simulation/calculation in the related thermal analysis in daytime radiative cooling. The main purpose is to provide some feasible tools, techniques in testing its thermal performance. It emphasizes the importance of objective and critical evaluation about different cooling performance results reported in papers since the results are significantly influenced by settings in both simulation and experiment.
An early-design stage assessment method based on constructibility for building performance evaluation
Authors: Contrada F , Kindinis A , Caron J-F , Gobin C 
Published: October 2019

Abstract
The goal of Zero Energy Buildings represents a challenge for designers: in order to meet required performance, a wide range of technologies and solutions is needed, and interactions with other stakeholders can limit productivity of building process. In this context, early-design stage plays a key role in building lifecycle: at this point, choices define design strategies, which strongly influence the following phases (developed design, construction and operational stages). In order to support decision making in early-design stage, we propose a new assessment method based on the French concept of constructibility, enabling designers to verify the relevancy and robustness of proposed solutions and process. Constructibility comes from buildability and constructability concepts, it sets some principles based on the anticipation of risks and considers both stakeholders’ satisfactions and building performance issues. The evaluation is based on seven criteria: the simplicity of the solution, the verifiability, project skills availability, the simplicity to manage, the compliance with user-centric requirements, sustainability, and cost efficiency. Multi-criteria assessment employs Analytic Hierarchy Process technique to consider professional feedbacks about risks of performance changing. In the case study, a modular office south-oriented in Paris, the multi-criteria assessment is used to enable a decision-making support between various envelope solutions. The method enables to report project weakness and it represents a new practical tool enhancing constructibility.
Model house F3 in Ljubljana – Nearly Zero-Energy Building
Authors: Varšek Damjana , Rak Gaj 
Published: October 2019

Abstract
Building F3, Model House is a multi-apartment building, located in the new “Zeleni Gaj” residential development in Ljubljana’s Brdo district. The architectural design of the multi-apartment low-energy structure involves vertical divisions into four distinct sections or “lamellas” (A, B, C and D). The lamellas differ from each other in terms of technology, structure and design/concept. This means that they differ above all in terms of the materials used for floor finishes and types of ventilation. As a Nearly Zero-Energy Building the building is also part of a special project researching living comfort in a multi-apartment building, which consist of a minimum three-year period of implementation, research and monitoring.
Epicuticular Compounds of Protopiophila litigata (Diptera: Piophilidae): Identification and Sexual Selection Across Two Years in the Wild
Authors: Angell Christopher S , Curtis Sharon , Ryckenbusch Anaïs , Rundle Howard D 
Published: October 2019

AbstractThe epicuticular compounds (ECs) of insects serve both to waterproof the cuticle and, in many taxa, as pheromones that are important for various social interactions, including mate choice within populations. However, ECs have not been individually identified in many species and most studies of their role in mate choice have been performed in a laboratory setting. Here we newly identify and quantify the ECs of the antler fly, Protopiophila litigata Bonduriansky, and use a cross-sectional selection analysis to quantify their association with male mating success in the wild across two years (2013 and 2017). The ECs of antler flies include straight-chain and methylated alkanes, alkenes, and a family of branched wax esters. We find all ECs to be shared between males and females but also demonstrate sexual dimorphism in the abundance of several. Male EC relative abundances were significantly associated with mating success in both years, although the multivariate direction of selection differed significantly between the years. Surprisingly, only two of the 18 compounds (or groups of compounds) we identified were similarly associated with mating success across the sampling years. In 2017, we further partitioned sexual selection into intra- and intersexual components, revealing selection on ECs to be significant via female choice but not male–male competition. Our study is one of few to investigate the potential role of ECs in mating success in the wild and adds to a growing body of evidence demonstrating significant temporal variability in selection in natural populations.
Invited Commentary: Religion as a Social Determinant of Health
Authors: Kawachi Ichiro 
Published: October 2019

Abstract
There is broad agreement that religion is a social determinant of health. In the article by Chen and VanderWeele (Am J Epidemiol. 2018;187(11):2355–2364), the authors took an outcome-wide approach to demonstrate associations between religious practices early in the life course (regular service attendance and prayer/mediation) and a wide range of health endpoints and behaviors later on. Is religion a panacea? The study adds to the evidence that religious practices are correlated with a broad swath of health outcomes. However, more work is needed to translate that evidence into practicable advice for individuals and for society. The following tasks remain. 1) We must sharpen our understanding of which elements of religious practices promote health. (Specifically, is it service attendance, prayer, or both? Could a nonreligious person achieve the same benefit via regular participation in a secular group, like a choir?). 2) We should improve our understanding of the different contexts in which religion is likely to have beneficial, as well as potentially harmful, effects.
The Population Impact of Late Presentation With Advanced HIV Disease and Delayed Antiretroviral Therapy in Adults Receiving HIV Care in Latin America
Authors: Belaunzarán-Zamudio Pablo F , Caro-Vega Yanink N , Shepherd Bryan E , Rebeiro Peter F , Crabtree-Ramírez Brenda E , Cortes Claudia P , Grinsztejn Beatriz , Gotuzzo Eduardo , Mejia Fernando , Padgett Denis , Pape Jean W , Rouzier Vanessa , Veloso Valdilea , Cardoso Sandra Wagner , McGowan Catherine C , Sierra-Madero Juan G ,   on behalf of the Caribbean, Central and South America network for HIV epidemiology (CCASAnet)
Published: October 2019

Abstract
Late presentation to care and antiretroviral therapy (ART) initiation with advanced human immunodeficiency virus (HIV) disease are common in Latin America. We estimated the impact of these conditions on mortality in the region. We included adults enrolled during 2001–2014 at HIV care clinics. We estimated the adjusted attributable risk (AR) and population attributable fraction (PAF) for all-cause mortality of presentation to care with advanced HIV disease (advanced LP), ART initiation with advanced HIV disease, and not initiating ART. Advanced HIV disease was defined as CD4 of &lt;200 cells/μL or acquired immune deficiency syndrome. AR and PAF were derived using marginal structural models. Of 9,229 patients, 56% presented with advanced HIV disease. ARs of death for advanced LP were 86%, 71%, and 58%, and PAFs were 78%, 58%, and 43% at 1, 5, and 10 years after enrollment. Among people without advanced LP, ARs of death for delaying ART were 39%, 32%, and 37% at 1, 5, and 10 years post-enrollment and PAFs were 20%, 14%, and 15%. Among people with advanced LP, ART decreased the hazard of death by 63% in the first year after enrollment, but 93% of these started ART; thus universal ART among them would reduce mortality by only 10%. Earlier presentation to care and earlier ART initiation would prevent most HIV deaths in Latin America.
Effectiveness of 1, 2, and 3 Doses of Human Papillomavirus Vaccine Against High-Grade Cervical Lesions Positive for Human Papillomavirus 16 or 18
Authors: Johnson Jones Michelle L , Gargano Julia Warner , Powell Melissa , Park Ina U , Niccolai Linda M , Bennett Nancy M , Griffin Marie R , Querec Troy , Unger Elizabeth R , Markowitz Lauri E ,   for the HPV-IMPACT Working Group
Published: October 2019

Abstract
Before 2016, human papillomavirus (HPV) vaccination was recommended on a 3-dose schedule. However, many vaccine-eligible US females received fewer than 3 doses, which provided an opportunity to evaluate the real-world vaccine effectiveness (VE) of 1, 2, and 3 doses. We analyzed data on cervical intraepithelial neoplasia (CIN) grades 2–3 and adenocarcinoma in situ (designated CIN2+) from the HPV Vaccine Impact Monitoring Project (HPV-IMPACT; 2008–2014). Archived tissue from CIN2+ lesions was tested for 37 types of HPV. Women were classified by number of doses received ≥24 months before CIN2+ detection. Using a test-negative design, VE was estimated as 1 minus the adjusted odds ratio from a logistic regression model that compared vaccination history for women whose lesions tested positive for HPV-16/18 (vaccine-type cases) with that for women who had all other CIN2+ lesions (controls). Among 3,300 women with available data on CIN2+, typing results, and vaccine history, 1,561 (47%) were HPV-16/18–positive, 136 (4%) received 1 dose of HPV vaccine, 108 (3%) received 2 doses, and 325 (10%) received 3 doses. Adjusted odds ratios for vaccination with 1, 2, and 3 doses were 0.53 (95% confidence interval (CI): 0.37, 0.76; VE = 47%), 0.45 (95% CI: 0.30, 0.69; VE = 55%), and 0.26 (95% CI: 0.20, 0.35; VE = 74%), respectively. We found significant VE against vaccine-type CIN2+ after 3 doses of HPV vaccine and lower but significant VE with 1 or 2 doses.
MIAmS: microsatellite instability detection on NGS amplicons data
Authors: Escudié Frédéric , Van Goethem Charles , Grand David , Vendrell Julie , Vigier Anna , Brousset Pierre , Evrard Solène M , Solassol Jérôme , Selves Janick 
Published: October 2019

Abstract

Summary
Microsatellite instability (MSI) is a molecular marker of DNA mismatch repair deficiency frequently at play in oncogenesis. MSI testing is used for diagnostic, prognostic and therapeutic purposes in several cancers. The current gold standard analysis for microsatellite status is based on length distribution analysis of multiplex-PCR generated DNA fragments from tumor samples which is a laborious and time consuming method. Next generation sequencing (NGS) using amplicon panels is an easy, accurate and scalable technique to determine both the microsatellite status and tumor genome mutations at the same time. Here, we describe MIAmS, an application designed to tag microsatellite status from amplicon NGS of tumor samples. Interestingly, this tool does not require paired normal tissue for comparison. In addition, this scalable application provides a user-friendly report for the interpretation of the results by biologists and exhibits a strong accuracy and robustness for determination of the MSI status.

Availability and implementation
https://github.com/bialimed/miams. Evaluation data are available at http://www.ebi.ac.uk/ena/data/view/PRJEB31725.

Supplementary information
Supplementary data are available at Bioinformatics online.
Improved Diagnostics Help to Identify Clinical Features and Biomarkers That Predict Mycoplasma pneumoniae Community-acquired Pneumonia in Children
Authors: Meyer Sauteur Patrick M , Krautter Selina , Ambroggio Lilliam , Seiler Michelle , Paioni Paolo , Relly Christa , Capaul Riccarda , Kellenberger Christian , Haas Thorsten , Gysin Claudine , Bachmann Lucas M , van Rossum Annemarie M C , Berger Christoph 
Published: October 2019

Abstract

Background
There are no reliable signs or symptoms that differentiate Mycoplasma pneumoniae (Mp) infection in community-acquired pneumonia (CAP) from other etiologies. Additionally, current diagnostic tests do not reliably distinguish between Mp infection and carriage. We previously determined that the measurement of Mp-specific immunoglobulin M antibody-secreting cells (ASCs) by enzyme-linked immunospot assay allowed for differentiation between infection and carriage. Using this new diagnostic test, we aimed to identify clinical and laboratory features associated with Mp infection.

Methods
This is a prospective cohort study of children, 3–18 years of age, with CAP from 2016 to 2017. Clinical features and biomarkers were compared between Mp-positive and -negative groups by Mann-Whitney U test or Fisher exact test, as appropriate. Area under the receiver operating characteristic curve (AUC) differences and optimal thresholds were determined by using the DeLong test and Youden J statistic, respectively.

Results
Of 63 CAP patients, 29 were Mp-positive (46%). Mp positivity was statistically associated with older age (median, 8.6 vs 4.7 years), no underlying disease, family with respiratory symptoms, prior antibiotic treatment, prolonged prodromal respiratory symptoms and fever, and extrapulmonary (skin) manifestations. Lower levels of C-reactive protein, white blood cell count, absolute neutrophil count, and procalcitonin (PCT), specifically PCT &lt;0.25 μg/L, were statistically associated with Mp infection. A combination of age &gt;5 years (AUC = 0.77), prodromal fever and respiratory symptoms &gt;6 days (AUC = 0.79), and PCT &lt;0.25 μg/L (AUC = 0.81) improved diagnostic performance (AUC = 0.90) (P = .05).

Conclusions
A combination of clinical features and biomarkers may aid physicians in identifying patients at high risk for Mp CAP.
Hidden Markov Model-based Load Balancing in Data Center Networks
Authors: He Binjie , Zhang Dong , Zhao Chang 
Published: October 2019

AbstractModern data centers provide multiple parallel paths for end-to-end communications. Recent studies have been done on how to allocate rational paths for data flows to increase the throughput of data center networks. A centralized load balancing algorithm can improve the rationality of the path selection by using path bandwidth information. However, to ensure the accuracy of the information, current centralized load balancing algorithms monitor all the link bandwidth information in the path to determine the path bandwidth. Due to the excessive link bandwidth information monitored by the controller, however, much time is consumed, which is unacceptable for modern data centers. This paper proposes an algorithm called hidden Markov Model-based Load Balancing (HMMLB). HMMLB utilizes the hidden Markov Model (HMM) to select paths for data flows with fewer monitored links, less time cost, and approximate the same network throughput rate as a traditional centralized load balancing algorithm. To generate HMMLB, this research first turns the problem of path selection into an HMM problem. Secondly, deploying traditional centralized load balancing algorithms in the data center topology to collect training data. Finally, training the HMM with the collected data. Through simulation experiments, this paper verifies HMMLB’s effectiveness.
Heterogeneity in migration strategies of Whooping Cranes
Authors: Pearse Aaron T , Metzger Kristine L , Brandt David A , Bidwell Mark T , Harner Mary J , Baasch David M , Harrell Wade 
Published: October 2019

AbstractMigratory birds use numerous strategies to successfully complete twice-annual movements between breeding and wintering sites. Context for conservation and management can be provided by characterizing these strategies. Variations in strategy among and within individuals support population persistence in response to changes in land use and climate. We used location data from 58 marked Whooping Cranes (Grus americana) from 2010 to 2016 to characterize migration strategies in the U.S. Great Plains and Canadian Prairies and southern boreal region, and to explore sources of heterogeneity in their migration strategy, including space use, timing, and performance. Whooping Cranes completed ~3,900-km migrations that averaged 29 days during spring and 45 days during autumn, while making 11–12 nighttime stops. At the scale of our analysis, individual Whooping Cranes showed little consistency in stopover sites used among migration seasons (i.e. low site fidelity). In contrast, individuals expressed a measure of consistency in timing, especially migration initiation dates. Whooping Cranes migrated at different times based on age and reproductive status, where adults with young initiated autumn migration after other birds, and adults with and without young initiated spring migration before subadult birds. Time spent at stopover sites was positively associated with migration bout length and negatively associated with time spent at previous stopover sites, indicating Whooping Cranes acquired energy resources at some stopover sites that they used to fuel migration. Whooping Cranes were faithful to a defined migration corridor but showed less fidelity in their selection of nighttime stopover sites; hence, spatial targeting of conservation actions may be better informed by associations with landscape and habitat features rather than documented past use at specific locations. The preservation of variation in migration strategies existing within this species that experienced a severe population bottleneck suggests that Whooping Cranes have maintained a capacity to adjust strategies when confronted with future changes in land use and climate.