bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of anatomical variation of the sacroiliac joint in asymptomatic young adults and its relationship with sacroiliac joint degeneration
Authors: Tok Umay Sermin , Korkmaz Mehmet 
Published: December 2019

AbstractIntroductionTo evaluate the variations of the sacroiliac joint (SIJ) in asymptomatic young adults and their relationship to SIJ degeneration.Materials and MethodsA total of 860 SIJs were retrospectively evaluated in 430 abdominal computed tomographies (CT) of abdominal pain cases. The study population consisted of 430 patients (176 female, 254 male) aged 20–45 years with abdominal pain. The anatomical variations of the SIJ were classified as (1) accessory sacroiliac joint, (2) iliosacral complex, (3) bipartite iliac bony plate, (4) semicircular defects, (5) crescent‐like iliac bony plate, and (6) ossification center. The CT findings of SIJ degeneration included joint space narrowing, sclerosis, subcortical cysts, vacuum phenomenon, and osteophytes. Chi‐square and cross tabulation tests were used for statistical analysis.ResultsThe iliosacral complex was the most common (bilateral) anatomical variation (7.7%, n = 66). A total of 71 SIJ degenerations were detected in cases with anatomical variations. They were determined in 22 (2.6%) iliosacral complex, 19 (2.2%) bipartite iliac bony plate, 15 (1.7%) accessory sacroiliac joint, 6 (0.7%) semicircular defect, 5 (0.6%) crescent‐like iliac bony plate, and 4 (0.5%) ossification center cases.ConclusionWe found that iliosacral complex was the most common SIJ variation in asymptomatic young adults and also that there was significantly more SIJ degeneration among subjects with anatomical variations of the SIJ than those without. SIJ degeneration was most common in subjects with the iliosacral complex variation.
Predictive factors for progression‐free survival in non‐small cell lung cancer patients receiving nivolumab based on performance status
Authors: Adachi Yuichi , Tamiya Akihiro , Taniguchi Yoshihiko , Enomoto Takatoshi , Azuma Kouji , Kouno Shunichi , Inagaki Yuji , Saijo Nobuhiko , Okishio Kyoichi , Atagi Shinji 
Published: December 2019

AbstractBackgroundNivolumab has promising efficacy for the treatment of non‐small cell lung cancer (NSCLC). Various predictive factors for nivolumab response in those with NSCLC have been reported, including performance status (PS). The objective of this retrospective study was to determine the predictive factors for nivolumab response in those with NSCLC with good PS and those with poor PS.MethodsWe retrospectively collected pretreatment clinical data of 296 consecutive patients with NSCLC treated with nivolumab. We investigated the relationship between progression‐free survival (PFS) and patient characteristics and analyzed predictive factors associated with good PS (PS 0‐1) or poor PS (PS 2‐4).ResultsThe median age of patients was 70 years; 206 patients were male, and 224 were classified as having good PS (PS 0‐1). The median PFS was 3.0 months, 3.7 months, and 1.2 months for all patients, patients with good PS, and patients with poor PS respectively. Multivariate analysis showed that never smoking (hazard ratio [HR], 1.77; 95% confidence interval [CI], 1.15‐2.75), high C‐reactive protein (CRP) (HR, 1.39; 95% CI, 1.00‐1.93), liver metastasis (HR, 1.95; 95% CI, 1.24‐3.07), pleural effusion (HR, 1.45; 95% CI, 1.06‐2.00), and steroid use (HR, 2.85; 95% CI, 1.65‐4.94) were associated with significantly shorter PFS in patients with good PS. A high advanced lung cancer inflammation index (ALI) was significantly associated with longer PFS in patients with poor PS (HR, 0.24; 95% CI, 0.08‐0.79).ConclusionsIn patients with NSCLC treated with nivolumab, the factors found to be predictive of shorter PFS in patients with good PS were never smoking, high CRP, liver metastasis, pleural effusion, and steroid administration, whereas high ALI was predictive of longer PFS in patients with poor PS.
Analysis of tumor markers in pleural effusion and serum to verify the correlations between serum tumor markers and tumor size, TNM stage of lung adenocarcinoma
Authors: Chen Zhongqing , Wang Ying , Fang Min 
Published: December 2019

AbstractBackgroundThe study of tumor markers (TM) in pleural effusion (PE) was not extensive.MethodsTM in PE and serum were analyzed to determine whether TM was expressed in intrathoracic and extrathoracic tissues. To further verify the correlations between serum TM and tumor size, TNM stage of lung adenocarcinoma.ResultsSerum AFP was not correlated with tumor size, T stage, N stage, and M stage (P > .05). Serum CEA, serum CA125, serum CA15‐3 were positively correlated with tumor size, T stage, N stage, M stage (P < .05). Serum CA19‐9 was not significantly correlated with tumor size and T stage (P > .05), but was positively correlated with N stage and M stage (P < .05). The levels of PE CEA, PE CA125, PE CA15‐3 were higher than those of serum CEA, serum CA125, serum CA15‐3 (all P < .05). The level of PE AFP was lower than that of serum AFP (P < .05). The level of PE CA19‐9 was not significantly different from that of serum CA19‐9 (P > .05). The positive rates of PE CEA and PE CA125 were higher than those of serum CEA and serum CA125 (P < .05). The positive rates of PE AFP, PE CA15‐3, PE CA19‐9 were not significantly different from those of serum AFP, serum CA15‐3, serum CA19‐9 (P > .05).PE CEA, PE CA125, PE CA15‐3 were moderately positively correlated with serum CEA, serum CA125, serum CA15‐3, respectively (r = 0.597; r = 0.46; r = 0.583, all P < .05). However, PE AFP and PE CA19‐9 were very strongly positively correlated with serum AFP and serum CA19‐9, respectively (r = 0.888; r = 0.874, all P < .05).ConclusionThe expression characteristics of TM in PE and serum supported the correlations between serum TM and tumor size, TNM stage of lung adenocarcinoma.
SCAI expert consensus statement update on best practices for transradial angiography and intervention
Authors: Shroff Adhir R. , Gulati Rajiv , Drachman Douglas E. , Feldman Dmitriy N. , Gilchrist Ian C. , Kaul Prashant , Lata Kusum , Pancholy Samir B. , Panetta Carmelo J. , Seto Arnold H. , Speiser Bernadette , Steinberg Daniel H. , Vidovich Mladen I. , Woody Walter W. , Rao Sunil V. 
Published: December 2019

AbstractTransradial angiography and intervention continues to become increasingly common as an access site for coronary procedures. Since the first “Best Practices” paper in 2013, ongoing trials have shed further light onto the safest and most efficient methods to perform these procedures. Specifically, this document comments on the use of ultrasound to facilitate radial access, the role of ulnar artery access, the utility of non‐invasive testing of collateral flow, strategies to prevent radial artery occlusion, radial access for primary PCI and topics that require further study.
Effect of postdilatation following balloon expandable transcatheter aortic valve implantation
Authors: Kawaguchi Tomohiro , Yamaji Kyohei , Ishizu Kenichi , Morinaga Takashi , Hayashi Masaomi , Isotani Akihiro , Kakumoto Shinichi , Arai Yoshio , Sakaguchi Genichi , Shirai Shinichi , Ando Kenji 
Published: December 2019

AbstractBackgroundPostdilatation after transcatheter heart valve (THV) implantation was associated with larger aortic valve areas in large‐scale registries; however, the specific effects of postdilatation are poorly understood.Methods and ResultsAmong a total of 224 consecutive patients who underwent transcatheter aortic valve replacement using SAPIEN 3, 121 patients (54.0%) underwent postdilatation (same contrast volume: N = 101, +1 ml: N = 17, +2 ml: N = 3). THV diameter was assessed (a) during, (b) after implantation, (c) during postdilatation, and (d) after postdilatation by quantitative fluoroscopy. In the overall patients (N = 224), acute recoil was observed from during implantation (23.0 ± 2.0 mm) to after implantation (22.5 ± 2.0 mm, p < .001) with an absolute recoil of 0.52 ± 0.25 mm. After postdilatation (N = 121), THV diameter significantly increased from 22.5 ± 2.0 mm to 22.9 ± 2.1 mm (p < .001), with smaller absolute recoil (0.39 ± 0.21 mm, p < .001). Compared with those who did not undergo postdilatation, patients who underwent postdilatation had larger postprocedural THV area assessed by multi‐slice computed tomography (471.4 ± 78.1 mm2 vs. 447.5 ± 76.3 mm2, p = .02) and larger effective orifice area (EOA) assessed by echocardiography throughout 1 year (at 30 day, 1.66 ± 0.33 cm2 vs. 1.45 ± 0.27 cm2, p < .001; at 6 month, 1.66 ± 0.33 cm2 vs. 1.44 ± 0.29 cm2, p < .001; at 1 year, 1.69 ± 0.38 cm2 vs. 1.47 ± 0.30 cm2, p < .001).ConclusionsPostdilatation after implantation of the SAPIEN 3 valve produced a larger THV diameter with less acute recoil, followed by larger EOA throughout 1 year. Further studies are needed to evaluate the impact of postdilatation on long‐term clinical outcomes.
Management of thymoma‐associated pure red cell aplasia: A novel use of blood substitute HBOC‐201 in a Jehovah’s Witness
Authors: Rubinstein Maria M. , Goss Cheryl , Avecilla Scott T. , Dubé Gregory P. , Riely Gregory J. , Mones Jodi V. 
Published: December 2019

AbstractPure red cell aplasia (PRCA) is a rare paraneoplastic syndrome occasionally associated with thymomas. Here, we report on the first ever use of a bovine hemoglobin‐based oxygen carrier, HBOC‐201 (HbO2 Therapeutics LLC; Hemopure®, Waltham, MA) for the supportive management of pure red cell aplasia in a Jehovah Witness patient.
Covalent Organic Frameworks (COFs) for Cancer Therapeutics
Authors: Guan Qun , Zhou Le‐Le , Li Wen‐Yan , Li Yan‐An , Dong Yu‐Bin 
Published: December 2019

AbstractAs newly emerged crystalline porous materials, covalent organic frameworks (COFs) possess fascinating structures and some specific features such as modularity, crystallinity, porosity, stability, versatility, and biocompatibility. Besides adsorption/separation, sensing, catalysis, and energy applications, COFs have recently shown a promise in biomedical applications. This contribution provides an overview of the recent developments of COF‐based medicines in cancer therapeutics, including drug delivery, photodynamic therapy (PDT), photothermal therapy (PTT), and combined therapy. Furthermore, the major challenges and developing trends in this field are also discussed. These recent developments are summarized and discussed to help encourage further contributions in this emerging and promising field.
Synthesis of Chiral β‐Lactams by Pd‐Catalyzed Enantioselective Amidation of Methylene C(sp3)–H Bonds
Authors: Zhou Tao , Jiang Meng‐Xue , Yang Xu , Yue Qiang , Han Ye‐Qiang , Ding Yi , Shi Bing‐Feng 
Published: December 2019

Summary of main observation and conclusionA Pd(II)‐catalyzed enantioselective intramolecular amidation of both benzylic and unbiased methylene C(sp3)−H bonds for the straightforward synthesis of chiral β‐lactams from aliphatic carboxamides is reported. The combination of 2‐pyridinylisopropyl (PIP) auxiliary with 3,3’‐substituted BINOL ligands is crucial for the enhancement of both reactivity and enantiocontrol of differentiating unbiased methylene C(sp3)−H bonds. The desired chemoselective C—N reductive elimination was achieved by employing 2‐fluoro‐1‐iodo‐4‐nitrobenzene as oxidant.
Are measures of marital satisfaction valid for women with depressive symptoms? The examination of factor structure and measurement invariance of the Couple Satisfaction Index‐4 across depression levels in Portuguese women
Authors: Lamela Diogo , Figueiredo Bárbara , Morais Ana , Matos Paula , Jongenelen Inês 
Published: December 2019

AbstractMarital satisfaction (MS) is a key indicator of mental and physical health. Factor structure of MS measures in individuals with clinical levels of depression as well as their measurement invariance across groups with different levels of depressive symptoms were not yet explored. The lack of evidence of measurement invariance might compromise valid comparisons between individuals with elevated and minimal depressive symptoms in MS. This study examined the factor structure of the Couple Satisfaction Index‐4 (CSI‐4) among women with clinical levels of depression, tested the CSI‐4 measurement invariance across depression levels groups, and investigated CSI‐4 convergent and divergent validity. Participants were 891 heterosexual married/cohabiting women who were assigned into one of two groups based on assessment of their levels of depressive symptoms. Participants completed the CSI‐4 and self‐reported measures used to examine convergent and divergent validity. Support was found for the factor structure of the CSI‐4 for the total sample and both elevated depressive symptoms and minimal depressive symptoms groups. Subsequent multigroup confirmatory factor analyses supported the measurement invariance of the CSI‐4 across depression levels groups. The CSI‐4 revealed excellent values of internal consistency and convergent and divergent validity. Our findings suggest that CSI‐4 produces comparable response patterns across depression groups and thus meaningful comparisons between groups can be performed.
A pharmacokinetics study of orally administered higenamine in rats using LC–MS/MS for doping control analysis
Authors: Wang Rui , Xiong Xiaoping , Yang Ming , He Sirui , Xu Xiaoping 
Published: December 2019

AbstractAccording to WADA guidelines, the presence of Higenamine (HG) in urine should not be ≥10 ng/mL. HG is widely found in materials used in Chinese herbal medicines as well as food and additives. This paper is the first method wherein a rat model has been used to evaluate the pharmacokinetics of orally administered HG by LC–MS/MS and would be helpful in doping control analysis. The method was found to be linear over a concentration range of 0.5(lower limit of quantification, LLOQ)–500 ng/mL for plasma and 0.5(LLOQ)–1000 ng/mL for urine. The values for intra‐ and inter‐day accuracy and precision did not deviate by >12.25% for HG in plasma and 5.87% in urine. Extraction recoveries of HG were 70.30–86.71% from plasma and 74.93%–79.29% from urine. HG was stable in plasma and urine after the extraction process and when exposed to different storage conditions. The findings of this study could provide some reference value for the assessment of HG misuse and for the control of intake and external application of HG‐related materials (foods and medicinal herbs). Our key findings are that high levels of external application or oral administration of HG‐rich materials may lead to a positive urine test for HG in athletes.
Food availability modulates temperature‐dependent effects on growth, reproduction, and survival in Daphnia magna
Authors: Betini Gustavo S. , Wang Xueqi , Avgar Tal , Guzzo Matthew M. , Fryxell John M. 
Published: December 2019

AbstractReduced body size and accelerated life cycle due to warming are considered major ecological responses to climate change with fitness costs at the individual level. Surprisingly, we know little about how relevant ecological factors can alter these life history trade‐offs and their consequences for individual fitness. Here, we show that food modulates temperature‐dependent effects on body size in the water flea Daphnia magna and interacts with temperature to affect life history parameters. We exposed 412 individuals to a factorial manipulation of food abundance and temperature, tracked each reproductive event, and took daily measurements of body size from each individual. High temperature caused a reduction in maximum body size in both food treatments, but this effect was mediated by food abundance, such that low food conditions resulted in a reduction of 20% in maximum body size, compared with a reduction of 4% under high food conditions. High temperature resulted in an accelerated life cycle, with pronounced fitness cost at low levels of food where only a few individuals produced a clutch. These results suggest that the mechanisms affecting the trade‐off between fast growth and final body size are food‐dependent, and that the combination of low levels of food and high temperature could potentially threaten viability of ectotherms.
Ecosystem scale evapotranspiration and CO2 exchange in burned and unburned peatlands: Implications for the ecohydrological resilience of carbon stocks to wildfire
Authors: Morison M. Q. , Petrone R. M. , Wilkinson S. L. , Green A. , Waddington J. M. 
Published: December 2019

AbstractBoreal peatlands represent a significant global store of soil carbon, which are subject to increasing natural and anthropogenic disturbance. Wildfire is the single largest disturbance to boreal forest and wetlands annually. Critical to the long‐term carbon storage function in peatlands is the (re‐)establishment of a near‐surface water table following wildfire. This has been recently shown to in part be facilitated by post‐fire reductions in water losses via evapotranspiration (ET). However, reduced ET may also have cascade impacts on other ecohydrological processes in recovering peatlands, such as a reduction in carbon sequestration. To investigate the linked cycles of evaporative loss and carbon exchange in burned peatlands, the burned and unburned peatlands in Alberta, Canada, were instrumented with eddy covariance systems to monitor continuous fluxes of energy, carbon dioxide, and water vapour, over two summer seasons (2013 and 2014; 2–3 years post‐burn). The burned site showed significant changes to respiration and productivity and a shift in the partitioning of available energy (significantly larger Bowen ratio; mean values of 1.19 and 1.10 at the burned and unburned sites, respectively), as well as a significant reduction in ET rates. Decreases in respiration did not offset the decrease in primary productivity, and the burned site was significantly less productive than the reference site on a net production basis for the available data period. This provides direct observations of ET and CO2 fluxes at a novel ecosystem scale to show the impacts of fire on short‐term (2–3 years) post‐burn ecosystem ecohydrological function.
Design and testing of highly transparent concentrator photovoltaic modules for efficient dual‐land‐use applications
Authors: Sato Daisuke , Yamada Noboru 
Published: December 2019

AbstractTwo types of highly transparent concentrator photovoltaic (CPV) modules that separately utilize direct sunlight and diffuse sunlight for efficient dual‐land‐use applications were designed and tested. The type A module, comprising a typical‐scale CPV lens and solar cells, has a completely direct‐diffuse‐separated design for power generation and other solar applications. On the other hand, the type B module, consisting of a microscale CPV lens and solar cells, was designed to increase the amount of direct sunlight transmitted based on an intentional reduction in the ratio of the lens aperture area to the module aperture area. In experiments, both modules exhibit higher electricity yields and module‐transmitted irradiances (MTIs) than those of a conventional partially transparent flat photovoltaic module with 17% efficiency Si solar cells. Furthermore, the modules show direct normal irradiance‐based efficiencies of 26.7% (type A) and 18.5% (type B) while simultaneously showing MTI‐to‐global normal irradiance ratios of 15.3%‐63.7% (type A) and 38.0%‐63.8% (type B) under various irradiance conditions. Thus, an irradiance of at least 160 W/m2 under the modules can be achieved even when they are arrayed without gaps (at a ground coverage ratio = 1).
Bioavailability Assessment of Metals in Freshwater Environments: A Historical Review
Authors: Adams William , Blust Ronny , Dwyer Robert , Mount David , Nordheim Eirik , Rodriguez Patricio H. , Spry Doug 
Published: December 2019

Abstract
Many metals (aluminum, cadmium, cobalt, copper, nickel, lead, zinc) are widely studied environmental contaminants because of their ubiquity, potential toxicity to aquatic life, and tendency for toxicity to vary widely as a function of water chemistry. The interactions between metal and water chemistry influence metal “bioavailability,” an index of the rate and extent to which the metal reaches the site of toxic action. The implications of metal bioavailability for ecological risk assessment are large, with as much as a 100-fold variability across a range of water chemistries in surface waters. Beginning as early as the 1930s, considerable research effort was expended toward documenting and understanding metal bioavailability as a function of total and dissolved metal, water hardness, natural organic matter, pH, and other water characteristics. The understanding of these factors and improvements in both analytical and computational chemistry led to the development of modeling approaches intended to describe and predict the relationship between water chemistry and metal toxicity, including the free ion activity model, the gill surface interaction model, the biotic ligand model, and additional derivatives and regression models that arose from similar knowledge. The arc of these scientific advances can also be traced through the evolution of the US Environmental Protection Agency's ambient water quality criteria over the last 50 yr, from guidance in the “Green Book” (1968) to metal-specific criteria produced in the last decade. Through time, water quality criteria in many jurisdictions have incorporated increasingly sophisticated means of addressing metal bioavailability. The present review discusses the history of scientific understanding of metal bioavailability and the development and application of models to incorporate this knowledge into regulatory practice. Environ Toxicol Chem 2019;39:48–59. © 2019 SETAC
Best Practices for Derivation and Application of Thresholds for Metals Using Bioavailability-Based Approaches
Authors: Van Genderen Eric , Stauber Jenny L. , Delos Charles , Eignor Diana , Gensemer Robert W. , McGeer James , Merrington Graham , Whitehouse Paul 
Published: December 2019

Abstract
The primary goal of the present study is to provide a broad view of best practices for evaluating bioavailability models for metals for use in the protection of aquatic life. We describe the state of the science regarding 1) the evaluation and selection of ecotoxicity data, 2) the selection of bioavailability models for use in normalization, and 3) subsequent application of bioavailability models. Although many examples of normalization steps exist worldwide, a scheme is proposed to evaluate and select a model that takes account of its representativeness (water chemistry and taxonomic coverage of the ecotoxicity data set) and validation performance. Important considerations for a suitable model are the quantity of inputs needed, accuracy, and ease of use, all of which are needed to set protective values for aquatic life and to use these values to evaluate potential risks to organisms in receiving waters. Although the end results of different model application approaches may be broadly similar, the differences in these application frameworks ultimately come down to a series of trade-offs between who needs to collect the data and use the bioavailability model, the different requirements of spatial scales involved (e.g., regional vs site-specific values), and model predictiveness and protectiveness. Ultimately, understanding the limits and consequences of these trade-offs allows for selection of the most appropriate model and application framework to best provide the intended levels of aquatic life protection. Environ Toxicol Chem 2019;39:118–130. © 2019 SETAC