bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reviewer Acknowledgements
Authors: Gibbs Nikki 
Published: May 2020

Applied Economics and Finance (AEF) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether AEF publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 7, Number 3 Ali Massoud, Sohag University, EgyptAyoub Taha Sidahmed, SIU, SudanFarhat Iqbal, University of Balochistan, PakistanHedieh Shadmani, Fairfield University, USAIulia Lupu, Victor Slavescu” Centre for Financial and Monetary Research, Romanian Academy, RomaniaKaveh Dalvand, University of Delaware, United StatesMagdalena Radulescu, University of Pitesti, RomaniaMagdalena Zioło, University of Szczecin, PolandMamdouh Abdelmoula M. Abdelsalam, Minufiya University, EgyptMohammed Al-Mahish, King Faisal University, Saudi ArabiaNana Rusadze, Akaki Tsereteli State University, GeorgiaNuno Crespo, ISCTE-IUL, PortugalPatrycja Kowalczyk-Rolczynska, Wroclaw University of Economics, PolandRajeev Rana, APB Govt. P.G. College, IndiaRamona Orastean, Lucian Blaga University of Sibiu, RomaniaRichard Nguyen, Alliant International University, USARomeo Victor Ionescu, Dunarea de Jos University, RomaniaRuhet Genc, Turkish-German University, TurkeyShahram Fattahi, Razi University, IranSzabolcs Blazsek, Universidad Francisco Marroquín, GuatemalaVictoria Cociug, Academy of Sciences of Moldova, MoldovaY. Saidi, M’sila University, AlgeriaZi-Yi Guo, Wells Fargo Bank, N.A., USAZuzana Janko, San Francisco State University, USA Nikki GibbsEditorial AssistantOn behalf of,The Editorial Board of Applied Economics and FinanceRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://aef.redfame.com
Enhancing responsiveness of human jejunal enteroids to host and microbial stimuli
Authors: Ruan Wenly , Engevik Melinda A. , Chang‐Graham Alexandra L. , Danhof Heather A. , Goodwin Annie , Engevik Kristen A. , Shi Zhongcheng , Hall Anne , Rienzi Sara C. Di , Venable Susan , Britton Robert A. , Hyser Joseph , Versalovic James 
Published: May 2020

Key pointsEnteroids are a physiologically relevant model to examine the human intestine and its functions.Previously, the measurable cytokine response of human intestinal enteroids has been limited following exposure to host or microbial pro‐inflammatory stimuli.Modifications to enteroid culture conditions facilitated robust human cytokine responses to pro‐inflammatory stimuli.This new human enteroid culture methodology refines the ability to study microbiome:human intestinal epithelium interactions in the laboratory.AbstractThe intestinal epithelium is the primary interface between the host, the gut microbiome and its external environment. Since the intestinal epithelium contributes to innate immunity as a first line of defence, understanding how the epithelium responds to microbial and host stimuli is an important consideration in promoting homeostasis. Human intestinal enteroids (HIEs) are primary epithelial cell cultures that can provide insights into the biology of the intestinal epithelium and innate immune responses. One potential limitation of using HIEs for innate immune studies is the relative lack of responsiveness to factors that stimulate epithelial cytokine production. We report technical refinements, including removal of extracellular antioxidants, to facilitate enhanced cytokine responses in HIEs. Using this new method, we demonstrate that HIEs have distinct cytokine profiles in response to pro‐inflammatory stimuli derived from host and microbial sources. Overall, we found that host‐derived cytokines tumour necrosis factor and interleukin‐1α stimulated reactive oxygen species and a large repertoire of cytokines. In contrast, microbial lipopolysaccharide, lipoteichoic acid and flagellin stimulated a limited number of cytokines and histamine did not stimulate the release of any cytokines. Importantly, HIE‐secreted cytokines were functionally active, as denoted by the ability of human blood‐derived neutrophil to migrate towards HIE supernatant containing interleukin‐8. These findings establish that the immune responsiveness of HIEs depends on medium composition and stimuli. By refining the experimental culture medium and creating an environment conducive to epithelial cytokine responses by human enteroids, HIEs can facilitate exploration of many experimental questions pertaining to the role of the intestinal epithelium in innate immunity.
Evaluation of PANS Methodology With Nonlinear Eddy Viscosity Closure: Flow Past a Heated Sphere
Authors: Saroha Sagar , Chakraborty Krishnendu , Sinha Sawan S. , Lakshmipathy Sunil 
Published: May 2020

Abstract
The partially averaged Navier–Stokes (PANS) approach has emerged as a viable scale-resolving bridging method over the last decade. Conventional PANS method, based on the linear eddy viscosity closure, overcomes the scale-resolving inadequacies of Reynolds-averaging but still suffers from limitations arising from linear constitutive modeling of turbulent stresses. Linear PANS has been evaluated in a variety of complex flow fields, including the benchmark case of flow around a sphere. In this work, the authors assess the potential of nonlinear eddy viscosity closure and further extend the evaluation of nonlinear closure in predicting thermal characteristics (besides hydrodynamics) of flow past a sphere. The presented evaluation has been performed on the basis of various surface-related and wake-related quantities. Our results are compared against available experimental and direct numerical simulation (DNS)/large eddy simulation studies. Our study shows that for the same value of the filter-control parameters, nonlinear PANS performs significantly better than linear PANS.
Closed-Loop Control of Transition by Local Dynamic Surface Modification
Authors: Rizzetta Donald P. , Visbal Miguel R. , Mishra Sandipan , Amitay Michael 
Published: May 2020

Abstract
Direct numerical simulations (DNSs) were carried out in order reproduce the generation and control of transition on a flat plate by means of local dynamic surface modification. The configurations and flow conditions duplicate those of previous numerical investigations, and are similar to an experimental arrangement, which employed piezoelectrically driven actuators to impart small amplitude local deformation of the plate surface. In those studies, one actuator was located in the upstream plate region, and oscillated at the most unstable frequency of 250 Hz in order to generate small disturbances, which amplified Tollmien–Schlichting instabilities. A second actuator placed downstream, was then oscillated at the same frequency, but with appropriate amplitudes in order to mitigate disturbance growth and delay the evolution of transition. Prior simulations employed an empirical process to determine optimal values of the control parameters. In the current effort, this process is replaced with a closed-loop control law. Numerical solutions are obtained to the two-dimensional and three-dimensional compressible Navier–Stokes equations, utilizing a high-fidelity numerical scheme and an implicit time-marching approach. Local surface modification of the plate is enforced via grid deformation. Results of the simulations are presented, and features of the flowfields are described. Comparisons are made between results obtained with the two control methods, and effectiveness of the closed-loop approach is evaluated.
Tracing shock-wave propagation in the Chicxulub crater: Implications for the formation of peak rings
Authors: Ebert Matthias , Poelchau Michael H. , Kenkmann Thomas , Schuster Bennet 
Published: May 2020

AbstractThe Chicxulub crater (Yucatán Peninsula, Mexico) is considered exceptional in many scientific aspects; morphologically it is the only known impact structure on Earth with a well-preserved peak ring. Recent drilling (International Ocean Discovery Program–International Continental Scientific Drilling Program Expedition 364) into this topographic feature provides insights into the structural properties and complex formation of a peak ring. By means of U-stage microscopy on shocked quartz grains from the granitic section of the recovered drill core, orientations of feather features (FFs) were determined and local principal axis of stress (σ1) orientations of the shock wave were derived. The FF orientations are strongly confined to a radially outward trend (WNW) relative to the crater center, which emphasizes a link between FF formation and the direction of shock-wave propagation. Thus, FFs represent an excellent tool as a stress-orientation indicator for the shock wave. Our microstructural data set shows that the granitic basement of the peak ring between ∼750 and ∼1200 m below seafloor behaved as a semi-coherent block above an imbricate thrust zone, and underwent both rotation and local folding during cratering. This validates the block sizes of acoustic fluidization employed in most Chicxulub-scale impact simulations. The folding of the upper part of the granitic basement may have developed by either (1) compression of the crater wall at the transient cavity and/or (2) dragging by the centripetal flow of the overlying crater material.
Attitudes and perceived barriers to mental healthcare in the People’s Liberation Army Navy: study from a navy base
Authors: Gu Ren-Ping , Liu X R , Ye X F 
Published: May 2020

IntroductionThe People’s Liberation Army (PLA, China) Navy is increasingly conducting military operations other than war overseas. Factors such as confrontations with pirates, special environments and long sailing times have resulted in mental health problems. However, the navy’s actual utilisation of mental health services is low. This study examined members’ rate of willingness to seek help and the factors that act as barriers to willingness to seek mental health services in the PLA Navy.MethodsThis cross-sectional study was conducted at the Zhoushan Base, operated by the East Sea Fleet, between March 2019 and April 2019. We distributed a 12-item questionnaire to examine participants’ attitudes and perceived barriers to mental healthcare. We recruited 676 navy personnel. Participants’ willingness to seek help if they had mental health problems was also assessed.ResultsThe response rate was 99%. A total of 88.44% of the sample reported being willing to seek help. Univariate analysis suggested that those not willing to seek help were more likely to agree with the items, ‘Mental healthcare does not work’ and ‘My unit leadership might treat me differently’ and all organisational barriers, and they were more likely to have concerns about ‘embarrassment’ and ‘being weak’ than those willing to seek help. After controlling for demographic characteristics, binary logistic regression analyses confirmed that a lack of knowledge regarding the location of mental health clinics and being perceived as weak were the main factors preventing participants’ willingness from seeking help.ConclusionsExtensive efforts to decrease organisational barriers and stigma towards mental healthcare should be a priority for researchers and policymakers to improve the usage of mental health services. Psychoeducation aimed at de-stigmatising mental health problems should be delivered and the accessibility and availability of mental health services should be increased.
Mass and half-life measurements of neutron-deficient iodine isotopes
Authors:   for the Super-FRS Experiment Collaboration, Ayet San Andrés Samuel , Mollaebrahimi Ali , Dickel Timo , Bergmann Julian , Ebert Jens , Geissel Hans , Greiner Florian , Haettner Emma , Hornung Christine , Kalantar-Nayestanaki Nasser , Miskun Ivan , Plaß Wolfgang R. , Purushothaman Sivaji , Rink Ann-Kathrin , Scheidenberger Christoph , Weick Helmut , Bagchi Soumya , Constantin Paul , Finlay Andrew , Kaur Satbir , Lippert Wayne , Mardor Israel , Mei Bo , Moore Iain , Otto Jan-Hendrick , Pietri Stephane , Pohjalainen Ilkka , Prochazka Andrej , Rappold Christophe , Reiter Moritz P. , Tanaka Yoshiki K. , Winfield John S. 
Published: May 2020

AbstractNeutron-deficient iodine isotopes, $$^{116}$$116I and $$^{114}$$114I, were produced at relativistic energies by in-flight fragmentation at the Fragment Separator (FRS) at GSI. The FRS Ion Catcher was used to thermalize the ions and to perform highly accurate mass measurements with a Multiple-Reflection Time-of-Flight Mass-Spectrometer (MR-TOF-MS). The masses of both isotopes were measured directly for the first time. The half-life of the $$^{114}$$114I was measured by storing the ions in an RF quadrupole for different storage times and counting the remaining nuclei with the MR-TOF-MS. The measured half-life was used to assign the ground state to the measured $$^{114}$$114I ions. Predictions on the possible $$\alpha $$α-decay branch for $$^{114}$$114I are presented based on the reduced uncertainties obtained for the $$Q_{\alpha }$$Qα-value. Systematic studies of the mass surface were performed with the newly obtained masses, showing better agreement with the expected trend in this mass region.
Strong deflection gravitational lensing by a Lee-Wick ultracompact object
Authors: Zhu Xing-Ye , Xie Yi 
Published: May 2020

AbstractWe study strong deflection gravitational lensing by a Lee-Wick ultracompact object. Its unique feature is a series of relativistic images inside its photon sphere, which are absent in the case of a black hole. We obtain its observables and estimate them for the supermassive black holes Sgr A* and M87* respectively in the Galactic center and in the center of M87. We find that the innermost relativistic image is a very promising signature according to its angular separation from the photon sphere and its considerable brightness. A preliminary bound on the UV scale of such an object is estimated based on the shadow of M87*.
DNA Methylation–Derived Immune Cell Profiles, CpG Markers of Inflammation, and Pancreatic Cancer Risk
Authors: Michaud Dominique S. , Ruan Mengyuan , Koestler Devin C. , Alonso Lola , Molina-Montes Esther , Pei Dong , Marsit Carmen J. , De Vivo Immaculata , Malats Núria , Kelsey Karl T. 
Published: May 2020

Abstract

Background:
Pancreatic cancer is projected to become the second most common cause of cancer-related death over the next 5 years. Because inflammation is thought to be a common trajectory for disease initiation, we sought to prospectively characterize immune profiles using DNA methylation markers and examine DNA methylation levels previously linked to inflammation biomarkers to evaluate whether these immune markers play a key role in pancreatic cancer.

Methods:
In a nested case–control study pooling three U.S. prospective cohort studies, DNA methylation was measured in prediagnostic leukocytes of incident pancreatic cancer cases and matched controls using the Illumina MethylationEPIC array. Differentially methylated regions were used to predict immune cell types, and CpGs previously associated with inflammatory biomarkers were selected for the analysis. DNA methylation data from a retrospective case–control study conducted in Spain (PanGenEU) was used for independent replication.

Results:
Immune cell proportions and ratio of cell proportions were not associated with pancreatic cancer risk in the nested case–control study. Methylation extent of CpGs residing in or near gene MNDA was significantly associated with pancreatic cancer risk in the nested case–control study and replicated in PanGenEU. Methylation level of a promoter CpG of gene PIM-1 was associated with survival in both studies.

Conclusions:
Using a targeted approach, we identified several CpGs that may play a role in pancreatic carcinogenesis in two large, independent studies with distinct study designs.

Impact:
These findings could provide insight into critical pathways that may help identify new markers of early disease and survival.
Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma
Authors: Kant Shiva , Kesarwani Pravin , Guastella Anthony R. , Kumar Praveen , Graham Stewart F. , Buelow Katie L. , Nakano Ichiro , Chinnaiyan Prakash 
Published: May 2020

Abstract
Glioblastoma is the most common primary malignant brain tumor in adults. Despite aggressive treatment, outcomes remain poor with few long-term survivors. Therefore, considerable effort is being made to identify novel therapies for this malignancy. Targeting tumor metabolism represents a promising therapeutic strategy and activation of fatty acid oxidation (FAO) has been identified as a central metabolic node contributing toward gliomagenesis. Perhexiline is a compound with a long clinical track record in angina treatment and commonly described as an FAO inhibitor. We therefore sought to determine whether this compound might be repurposed to serve as a novel therapy in glioblastoma. Perhexiline demonstrated potent in vitro cytotoxicity, induction of redox stress and apoptosis in a panel of glioblastoma cell lines. However, the antitumor activity of perhexiline was distinct when compared with the established FAO inhibitor etomoxir. By evaluating mitochondrial respiration and lipid dynamics in glioblastoma cells following treatment with perhexiline, we confirmed this compound did not inhibit FAO in our models. Using in silico approaches, we identified FYN as a probable target of perhexiline and validated the role of this protein in perhexiline sensitivity. We extended studies to patient samples, validating the potential of FYN to serve as therapeutic target in glioma. When evaluated in vivo, perhexiline demonstrated the capacity to cross the blood–brain barrier and antitumor activity in both flank and orthotopic glioblastoma models. Collectively, we identified potent FYN-dependent antitumor activity of perhexiline in glioblastoma, thereby, representing a promising agent to be repurposed for the treatment of this devastating malignancy.
Inhibition of Tumor Cell Growth and Cancer Stem Cell Expansion by a Bispecific Antibody Targeting EGFR and HER3
Authors: Rau Alexander , Lieb Wolfgang S. , Seifert Oliver , Honer Jonas , Birnstock Dennis , Richter Fabian , Aschmoneit Nadine , Olayioye Monilola A. , Kontermann Roland E. 
Published: May 2020

Abstract
The frequent activation of HER3 signaling as a resistance mechanism to EGFR-targeted therapy has motivated the development of combination therapies that block more than one receptor tyrosine kinase. Here, we have developed a novel tetravalent, bispecific single-chain diabody-Fc fusion protein targeting EGFR and HER3 (also known as ErbB3) that integrates the antigen-binding sites of a humanized version of cetuximab as well as a recently developed anti-HER3 antibody, IgG 3-43. This bispecific antibody combines the binding and neutralizing properties of the parental antibodies, as observed in biochemical and in vitro two-dimensional and three-dimensional cell culture assays, and gave rise to long-lasting growth suppression in a subcutaneous xenograft head and neck tumor model. In triple-negative breast cancer (TNBC) cell lines, treatment with the bispecific antibody inhibited the proliferation and oncosphere formation efficiency driven by HER3 signaling. In an orthotopic MDA-MB-468 tumor model, this translated into antitumor effects superior to those obtained by the parental antibodies alone or in combination and was associated with a reduced number of cells with stem-like properties. These findings demonstrate that the bispecific antibody efficiently blocks not only TNBC proliferation, but also the survival and expansion of the cancer stem cell population, holding promise for further preclinical development.
Evaluation of psoriasis skin disease classification using convolutional neural network
Authors: Binti Roslan Rosniza , Mohd Razly Iman Najwa , Sabri Nurbaity , Ibrahim Zaidah 
Published: May 2020

<span lang="EN-GB">Skin disease has lower impact on mortality compared to others but instead it has greater effect on quality of life because it involves symptoms such as pain, stinging and itchiness. Psoriasis is one of the ordinary skin diseases which are relapsing, chronic and immune-mediated inflammatory disease. It is estimated about 125 million people worldwide being infected with various types of skin infection. </span><span lang="EN-GB">Challenges arise when patients only predict the skin type disease they had without being accurately and precisely examined. This is because as human being, they only observe and look at the diseases on the surface of the skin with their naked eye, where there are some limits, for example, human vision lacks of accuracy, reproducibility and quantification in the collection of image information. As Plaque and Guttate are the most common Psoriasis skin disease happened among people, this paper presents an evaluation of Psoriasis skin disease classification using Convolutional Neural Network. A total of 187 images which consist of 82 images for Plaque Psoriasis and 105 images for Guttate Psoriasis has been used which are retrieved from Psoriasis Image Library, International Psoriasis Council (IPC) and DermNet NZ. Convolutional Neural Network (CNN) is applied in extracting features and analysing the classification of Psoriasis skin disease. This paper showed the promising used of CNN with the accuracy rate of 82.9% and 72.4% for Plaque and Guttate Psoriasis skin disease, respectively.</span>
Rhythm Violation Enhances Auditory-Evoked Responses to the Extent of Overriding Sensory Adaptation in Passive Listening
Authors: Menceloglu Melisa , Grabowecky Marcia , Suzuki Satoru 
Published: May 2020

Abstract
Sensory systems utilize temporal structure in the environment to build expectations about the timing of forthcoming events. We investigated the effects of rhythm-based temporal expectation on auditory responses measured with EEG recorded from the frontocentral sites implicated in auditory processing. By manipulating temporal expectation and the interonset interval (IOI) of tones, we examined how neural responses adapted to auditory rhythm and reacted to stimuli that violated the rhythm. Participants passively listened to the tones while watching a silent nature video. In Experiment 1 (n = 22), in the long-IOI block, tones were frequently presented (80%) with 1.7-sec IOI and infrequently presented (20%) with 1.2-sec IOI, generating unexpectedly early tones that violated temporal expectation. Conversely, in the short-IOI block, tones were frequently presented with 1.2-sec IOI and infrequently presented with 1.7-sec IOI, generating late tones. We analyzed the tone-evoked N1–P2 amplitude of ERPs and intertrial phase clustering in the theta–alpha band. The results provided evidence of strong delay-dependent adaptation effects (short-term, sensitive to IOI), weak cumulative adaptation effects (long-term, driven by tone repetition over time), and robust temporal-expectation violation effects over and above the adaptation effects. Experiment 2 (n = 22) repeated Experiment 1 with shorter IOIs of 1.2 and 0.7 sec. Overall, we found evidence of strong delay-dependent adaptation effects, weak cumulative adaptation effects (which may most efficiently accumulate at the tone presentation rate of ∼1 Hz), and robust temporal-expectation violation effects that substantially boost auditory responses to the extent of overriding the delay-dependent adaptation effects likely through mechanisms involved in exogenous attention.