bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sociodemographic and Behavioral Factors Associated with Diet Quality among Low-income Community Health Center Patients with Hypertension
Authors: Cheng Jessica , Faulkner Katherine C , Malone Ashlie , Gu Kristine D. , Thorndike Anne N 
Published: December 2024

AbstractObjectiveIdentify the most important sociodemographic and behavioral factors related to the diet of low-income adults with hypertension in order to guide the development of a community health worker (CHW) healthy eating intervention for low-income populations with hypertension.Design:In this cross-sectional analysis, dietary recalls were used to assess Healthy Eating Index-2020 (HEI-2020) total (range: 0 to 100 [best diet quality]) and component scores and sodium intake. Self-reported sociodemographic and behavioral data were entered into a Least Absolute Shrinkage and Selection Operator (LASSO) regression model to determine the relative importance of factors related to diet quality.SettingFive community health centers in Boston, Massachusetts.ParticipantsAdults (>20 years old) with a hypertension diagnosis.ResultsParticipants (N=291) were mostly female (65.0%), on Medicaid (82.8%), food insecure (59.5%), and Hispanic (52.2%). The mean (95% CI) HEI-2020 score was 63.0 (62.3, 65.7) Component scores were low for sodium and whole grains; mean (SE) sodium intake was 2676.9 (45.5) mg/day. The most important factors associated with lower HEI-2020 scores were: not having own housing, male gender, tobacco use, marijuana use, and skipping meals; the most important factors associated with higher HEI-2020 scores were Hispanic ethnicity and receipt of community food resources (5-fold cross-validated R2=0.17).ConclusionsIn this population of low-income adults with hypertension, diet quality would be improved by reducing sodium and increasing whole grain intake. Healthy eating interventions among low-income populations should consider providing dietary guidance in the context of behavioral factors (e.g., meal skipping) and substance use (e.g., marijuana) and should address barriers to health eating through referral to community food resources (e.g., food pantries).
Hyperorality in Frontotemporal Dementia: How Psychiatric and Neural Correlates Change Across the Disease Course
Authors: Morrow Christopher B. , Onyike Chiadi , Pantelyat Alexander , Smith Gwenn S. , Leoutsakos Jeannie , Faria Andreia V. , Graff-Radford Neill R. , Darby R. Ryan , Ghoshal Nupur , Staffaroni Adam M. , Rascovsky Katya , Miyagawa Toji , Balaji Akshata , Tsapkini Kyrana , Lapid Maria I. , Mendez Mario F. , Litvan Irene , Pascual Belen , Rojas Julio C. , Wszolek Zbigniew K. , Domoto-Reilly Kimiko , Kornak John , Kamath Vidyulata 
Published: December 2024

AbstractObjectivesHyperorality is one of the core features of behavioral variant frontotemporal dementia (bvFTD), however, the cognitive, psychiatric, and neuroanatomic correlates of hyperorality across disease stages remain unclear. This study works to fill this knowledge gap by exploring these associations in the early and advanced stages of bvFTD.MethodsParticipants with sporadic and genetic bvFTD were enrolled in the ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration consortium (ALLFTD). The primary analyses used baseline data to compare cognitive and psychiatric symptoms in those with and without hyperorality stratified by disease severity. Linear multivariable regressions adjusting for age and total intracranial volume were used to examine baseline associations between regional gray matter volumes and hyperorality status. Five anatomic regions of interest were pre-selected for analysis based on previously identified neuroanatomic correlates of hyperorality in bvFTD.ResultsHyperorality was present in 50% of early-stage bvFTD participants (n = 136) and was associated with higher rates of ritualistic/compulsive behavior. Hyperorality was present in 63% of advanced-stage participants (n = 208) and was associated higher rates of apathy, and ritualistic/compulsive behavior. Regional gray matter volumes were similar in those with and without hyperorality in early-stage participants. In the advanced-stage participants, hyperorality was associated with lower gray matter volumes in the right dorsal and ventral striatum.ConclusionsHyperorality emerges early in bvFTD and is accompanied by deficits in social cognition and complex-ritualistic behavior prior to clinically significant gray matter volume loss. These findings suggest that early identification and treatment of hyperorality could improve neuropsychiatric trajectories in bvFTD.
Laser Ablation of Periventricular Nodular Heterotopia for Medically Refractory Epilepsy
Authors: McCormack Ryan M. , Chandran Arjun S , Lhatoo Samden D. , Pati Sandipan , Li Zhouxuan , Harris Katherine , Lacuey Nuria , Kalamangalam Giridhar , Thompson Stephen , Tandon Nitin 
Published: December 2024

AbstractObjectivePeriventricular Nodular Heterotopia (PVNH) is the most common neuronal heterotopia, frequently resulting in pharmaco-resistant epilepsy. PVNH has a deep location which renders localization of seizure onsets and traditional surgical therapy challenging and of limited success. Here we characterize variables that predict good epilepsy outcomes following surgical intervention using SEEG-informed MRgLITT.MethodsA prospectively compiled surgical epilepsy database from a single high-volume epilepsy referral center was used to identify patients who underwent SEEG evaluation for PVNH and characterize the intervention on outcomes.ResultsThirty-nine patients underwent SEEG-informed MRgLITT. Associated imaging abnormalities— mesial temporal sclerosis (MTS) or polymicrogyria (PMG) were treated based on SEEG.SEEG-guided MRgLITT of the seizure onset zone (SoZ) in PVNH and associated epileptic tissue was carried out. PVNH and PMG were densely sampled—mean 16.5(SD=2)/209.4(SD=36.9) SEEG probes/recording contacts. A single trajectory was used in 18, two in 13, and three or more in eight patients. Volumetric analyses revealed a high percentage of PVNH SoZ ablation (96.6%, SD=5.3%) in unilateral and bilateral (92.9%, SD=7.2%) cases. Mean follow-up duration was 31.4 months (SD=20.9). Seizure freedom was excellent overall: unilateral PVNH without other imaging abnormalities—80%; PVNH with MTS or PMG—63%; Bilateral PVNH—50%. SoZ ablation percentage significantly impacted surgical outcomes (p<0.001).InterpretationPVNH plays a central role in seizure genesis. MRgLITT represents a transformative technological advance in PVNH-associated epilepsy with seizure control outcomes consistent with those seen in focal lesional epilepsies. In localized unilateral cases and otherwise normal imaging, performing PVNH ablation without invasive recordings may be reasonable.
A Mixed-Methods Investigation of Coping, Adaptation and Health-Related
Quality of Life in Individuals Experiencing Endometriosis
Authors: Moore Chloe , Cogan Nicola , Williams Lynn 
Published: December 2024

Abstract

Objectives
Endometriosis is associated with reduced health-related quality of life
(HRQoL). Coping has been linked to HRQoL in this population but longitudinal
research to establish the impact of coping on HRQoL over time is lacking.
Additionally, limited research has examined coping and adaptation to
endometriosis from an in-depth qualitative or mixed-methods perspective.
Therefore, adopting a mixed-methods approach, the current research aimed to
investigate how individuals experiencing endometriosis coped and adapted to
their condition, and the extent to which coping predicted HRQoL over
time.

Design
A sequential, mixed-methods design incorporating a two-wave longitudinal
survey and semi-structured interviews.

Methods
408 UK-based participants diagnosed with endometriosis completed the
baseline survey, measuring demographics, clinical factors, and coping with
283 completing the follow-up survey assessing HRQoL a year later. Data was
analysed through hierarchical regression analysis. Meanwhile, 30
semi-structured interviews were conducted and analysed using reflexive
thematic analysis. Findings were integrated by considering points of
convergence, divergence, and complementarity between the datasets.

Results
Analysis of the quantitative data indicated an enduring impact of coping
on HRQoL. Avoidant strategies and endometriosis-related information-seeking
predicted reduced HRQoL, whilst trust in medical care exerted a protective
function. Three themes were constructed from the qualitative data:
disconnection from the body; balancing boundaries and self-care; and
empowered adaptation. Integration of the datasets emphasised the significant
impact of coping on HRQoL and wellbeing, revealing avoidance and positive
adaptation as prominently employed coping strategies.

Conclusions
The results position coping as an important therapeutic target in
endometriosis care, particularly through fostering empowerment and
adaptation to support HRQoL.
Orbitofrontal cortex hypergyrification in hallucinating schizophrenia patients: surface ratio as a promising brain biomarker
Authors: Núñez Christian , Stephan-Otto Christian , Roldán Alexandra , Grasa Eva Mª , Escartí Mª José , Aguilar García-Iturrospe Eduardo J. , García-Martí Gracián , de la Iglesia-Vaya Maria , Nacher Juan , Portella Maria J. , Corripio Iluminada 
Published: December 2024

BackgroundThere has been increasing interest in the study of brain gyrification in schizophrenia since it may provide additional useful information on the cytoarchitecture and connectivity of the brain. Various methods have been developed to estimate brain gyrification that, so far, have yielded mixed and inconclusive results in schizophrenia studies. To the best of our knowledge, an alternative method to compute brain gyrification, known as surface ratio (SR), has not yet been applied to a schizophrenia sample. Our aim in this study was to assess whether SR could provide new insights on the brain structure of schizophrenia patients and the severity of symptoms. We also computed a more established brain gyrification measure, namely absolute mean curvature (AMC), for comparison.MethodWe processed and analyzed a total of 63 magnetic resonance images, 25 from schizophrenia patients with treatment-resistant auditory verbal hallucinations (SCH-H), 18 from schizophrenia patients without hallucinations (SCH-NH), and 20 from healthy controls (HC). We estimated brain gyrification with SR and AMC employing CAT software.ResultsThe SR measure mainly revealed that SCH-H patients had a more folded orbitofrontal cortex than SCH-NH patients and HC. Gyrification in this region was also negatively associated with positive symptoms, specifically with the delusions and conceptual disorganization items, only in the SCH-H group. Conversely, SCH-NH and HC showed more SR than SCH-H in other frontal areas. As for the AMC measure, we identified two areas where HC showed more gyrification than SCH-H patients, but no relationships arose with symptoms.DiscussionWe hypothesize that the hypergyrification of the orbitofrontal cortex displayed by SCH-H patients, as captured by the SR measure, suggests aberrant and/or excessive wiring in these patients, which in turn could give rise to auditory verbal hallucinations. Alternatively, we comment on potential compensatory mechanisms that may better explain the negative association between orbitofrontal gyrification and positive symptomatology. Importantly, the estimation of brain gyrification with the SR measure seems to capture the most relevant differences and associations, making it a promising biomarker in schizophrenia research.
The WHO Disease Outbreak News during the Covid-19 pandemic
Authors: Weets Ciara M. , Carlson Colin J. , Robertson Hailey , Toole Kate , McGivern Lauren , Graeden Ellie , Katz Rebecca 
Published: December 2024

AbstractDuring the Covid-19 pandemic, the World Health Organization (WHO) was faced with the task of regular public updating—about both the pandemic itself, and hundreds or potentially thousands of other health emergencies. Here, we examined the 242 reports published in the WHO Disease Outbreak News (DON) during the first four years of the Covid-19 pandemic (2020 to 2023), and document the diseases and regions that were reported. We find that multinational epidemics of diseases like Ebola virus and MERS-CoV continue to dominate the DON. However, recent years have also seen more reports of climate-sensitive infectious diseases, as well as a state shift in influenza outbreak reporting in both China and the rest of the world. Surprisingly, the DON was only minimally used to document the Covid-19 pandemic and the global mpox epidemic, almost exclusively before the declaration of a public health emergency of international concern. Notably, inconsistent reporting related to Covid-19 variants of concern speaks to the ongoing evolution of the DON as a resource, and potentially, to its complicated relationship with international travel and trade restrictions. We suggest that researchers should continue to exercise caution when treating the DON as a global record of outbreak history, but that the DON is a compelling record of the WHO itself, including the process it uses to assess outbreak risk.
Sourcing Bivariate Genetic Overlap for Polygenic Prediction using MiXeR-Pred
Authors: Parker Nadine , Cheng Weiqiu , Hindley Guy F. L. , O’Connell Kevin S. , Parekh Pravesh , Hagen Espen , Smeland Olav B. , Djurovic Srdjan , Shadrin Alexey A. , Andreassen Ole A. , Frei Oleksandr , Dale Anders M. 
Published: December 2024

AbstractThe past two decades have seen the advent and mass application of genome-wide association studies (GWAS). The observation that complex phenotypes are polygenic has contributed to the development of the polygenic score (PGS) for understanding individual-level genetic predisposition. There have been substantial advances in PGS methodology in recent years. However, few methods leverage the pleiotropic nature of complex phenotypes for polygenic prediction. Here, we present MiXeR-Pred, a novel approach for polygenic prediction that builds on an established MiXeR framework to source genetic overlap with a secondary phenotype to inform PGS prediction of a primary phenotype. We apply MiXeR-Pred using both bipolar disorder and schizophrenia as complex primary phenotypes along with the following secondary phenotypes: education attainment, major depressive disorder, and measures of cortical brain morphology. We compare MiXeR-Pred predictions to the PGS derived from each primary phenotype’s GWAS in addition to the multi-trait analysis of GWAS (MTAG) approach, which can use correlated secondary phenotypes to boost discovery and prediction for a primary phenotype. We show that MiXeR-Pred improves prediction performance when compared to both the primary GWAS and MTAG PGS, regardless of the secondary phenotype. Not only can MiXeR-Pred be used to further our understanding of pleiotropy among complex phenotypes, but it also provides a novel conceptualization of how one can source pleiotropy to improve PGS performance which can ultimately contribute to advancements in personalized medicine. The MiXeR-Pred tool is available athttps://github.com/precimed/mixer-pred.
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
Authors: Jerez Pilar Álvarez , Wild Crea Peter A. , Ramos Daniel M. , Gustavsson Emil K. , Radefeldt Mandy , Makarious Mary B. , Ojo Oluwadamilola O. , Billingsley Kimberley J. , Malik Laksh , Daida Kensuke , Bromberek Sarah , Hu Carol , Schneider Zachary , Surapaneni Aditya L. , Stadler Julia , Rizig Mie , Morris Huw R. , Pantazis Caroline B. , Leonard Hampton L. , Screven Laurel , Qi Yue A. , Nalls Mike A. , Bandres-Ciga Sara , Hardy John , Houlden Henry , Eng Celeste , Burchard Esteban González , Kachuri Linda ,   Global Parkinson’s Genetics Program (GP2), Singleton Andrew B. , Fischer Steffen , Bauer Peter , Reed Xylena , Ryten Mina , Beetz Christian , Ward Michael , Okubadejo Njideka U. , Blauwendraat Cornelis 
Published: December 2024

AbstractRecently, a novel African ancestry specific Parkinson’s disease (PD) risk signal was identified at the gene encoding glucocerebrosidase (GBA1). This variant (rs3115534-G) is carried by ∼50% of West African PD cases and imparts a dose-dependent increase in risk for disease. The risk variant has varied frequencies across African ancestry groups, but is almost absent in European and Asian ancestry populations.GBA1is a gene of high clinical and therapeutic interest. Damaging bi-allelic protein-coding variants cause Gaucher disease and mono-allelic variants confer risk for PD and Dementia with Lewy Bodies, likely by reducing the function of glucocerebrosidase. Interestingly, the novel African ancestry specificGBA1risk variant is a non-coding variant, suggesting a different mechanism of action. Using full length RNA transcript sequencing, we identified intron 8 expression in risk variant carriers (G) but not in non-variant carriers (T). Antibodies targeting the N-terminus of glucocerebrosidase showed that this intron-retained isoform is likely not protein coding and subsequent proteomics did not identify a shorter protein isoform, suggesting the disease mechanism is RNA-based. CRISPR editing of the reported index variant (rs3115534) revealed that this is the responsible sequence alteration driving production of these intron 8 containing transcripts. Follow-up analysis of this variant showed that it is in a key intronic branchpoint sequence and therefore has important implications in splicing and disease. In addition, when measuring glucocerebrosidase activity we identified a dose-dependent reduction in risk variant carriers (G). Overall, we report the functional effect of aGBA1non-coding risk variant, which acts by interfering with the splicing of functionalGBA1transcripts, resulting in reduced protein levels and reduced glucocerebrosidase activity. This understanding reveals a novel therapeutic target in an underserved and underrepresented population.
Inconsistent Music-Based Intervention Reporting in Dementia Studies: A Systematic Mapping Review
Authors: Lepping Rebecca J. , Hess Benjamin J. , Taylor Jasmine M. , Hanson-Abromeit Deanna , Williams Kristine N. 
Published: December 2024

ABSTRACTRecent research has shown beneficial results for music-based interventions (MBIs) for persons living with Alzheimer’s disease and related dementias (AD/ADRD), but reports often lack sufficient detail about the MBI methodology, which reduces replicability. A detailed checklist for best practices in how to report MBIs was created in 2011 by Robb and colleagues to remedy the lack of detail in MBI descriptions. The implementation of the checklist specifically in AD/ADRD research has not been established. Given the complexity of music and the variety of uses for research and health, specific MBI descriptions are necessary for rigorous replication and validation of study results.This systematic mapping review utilized the “Checklist for Reporting Music-Based Interventions” to evaluate the current state of MBI descriptive specificity in AD/ADRD research. Research articles testing MBIs and reviews of MBI efficacy published between January 2015 and August 2023 were scored using the checklist and the results were summarized. Nineteen studies were screened, and reporting was inconsistent across the 11 checklist criteria. Six out of 19 studies fully reported more than 5 of the 11 criteria. Only one of the 11 scoring criteria was at least partially reported across all 19 studies.Thorough reporting of intervention detail for MBIs remains limited in AD/ADRD MBI research. This impedes study validation, replication, and slows the progress of research and potential application of music in practice. Greater implementation of the reporting guidelines provided by Robb and colleagues would move the field of MBI research for AD/ADRD forward more quickly and efficiently.
Early, robust mucosal secretory IgA but not IgG response to SARS-CoV-2 spike in oral fluid is associated with faster viral clearance and COVID-19 symptom resolution
Authors: Pisanic Nora , Antar Annukka A. R. , Hetrich Marissa K. , Demko Zoe O. , Zhang Xueyan , Spicer Kristoffer , Kruczynski Kate L. , Detrick Barbara , Clarke William , Knoll Maria Deloria , Thomas David L. , Dawood Fatimah S. , Veguilla Vic , Karron Ruth A. , Manabe Yukari C. , Heaney Christopher D. 
Published: December 2024

AbstractHigh priority efforts are under way to support the development of novel mucosal COVID-19 vaccines, such as the US Government’s ProjectNextGenand the Center for Epidemic Preparedness Innovations’ (CEPI) goal to respond to the next pandemic with a new vaccine in 100 days. However, there is limited consensus about the complementary role of mucosal immunity in disease progression and how the immunogenicity of mucosal vaccines will be evaluated. This study investigated the role of oral mucosal antibody responses in viral clearance and in COVID-19 symptom duration.Participants with PCR-confirmed SARS-CoV-2 infection provided oral fluid for testing with SARS-CoV-2 antibody multiplex assays, nasal swabs for RT-PCR and symptom information at up to eight follow-ups from April 2020 to February 2022.High and moderate oral fluid anti-spike (S) SIgA post infection was associated with significantly higher likelihood of viral clearance and of COVID-19 symptom resolution across age groups. Those with high and moderate anti-S SIgA cleared the virus and recovered 14 days (95% CI: 10-18 days) and 9-10 days (95% CI: 6-14 days) earlier, respectively. Delayed but higher oral fluid anti-S IgG was associated with significantly longer time to viral clearance and recovery. The effect size of moderate or high SIgA was equivalent to prior COVID-19 vaccine immunity, which was also associated with faster clearance and recovery. Unvaccinated adults with prolonged COVID-19 symptoms had significantly lower anti-RBD SIgA 15-30 days after infection onset (p<0.001).Robust mucosal SIgA early post infection appears to support faster clearance of SARS-CoV-2 and recovery from COVID-19 symptoms. This research underscores the importance of harmonizing mucosal immune response assays to evaluate new vaccines that can boost local mucosal immunity.DisclaimerThe findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Using Coincidence Analysis to Identify Causal Chains of Factors Associated with Implementation and Optimization of Lynch Syndrome Tumor Screening Across Multiple Health care Systems
Authors: Cragun Deborah , Salvati Zachary M , Schneider Jennifer L , Burnett-Hartman Andrea N , Epstein Mara M , Hunter Jessica Ezzell , Liang Su-Ying , Lowery Jan , Lu Christine Y. , Pawloski Pamala A. , Schleider Victoria , Sharaf Ravi N , Williams Marc S , Rahm Alanna Kulchak 
Published: December 2024

ABSTRACTPurposeThis study of multiple case study compared Lynch syndrome universal tumor screening (UTS) to understand multi-level factors that may impact the successful implementation of complex programs.MethodsData from 66 stakeholder interviews were used to conduct multi-value coincidence analysis (mv-CNA) and identify key factors that consistently make a difference in whether UTS programs were implemented and optimized at the system level.ResultsThe selected CNA model revealed combinations of conditions that distinguish 4 optimized UTS programs, 10 non-optimized programs, and 4 systems with no program. Fully optimized UTS programs had both a maintenance champion and a positive inner setting. Two independent paths were unique to non-optimized programs: 1) positive attitudes and a mixed inner setting, or 2) limited planning & engaging among stakeholders. Negative views about UTS evidence or lack of knowledge about UTS led to a lack of planning and engaging, which subsequently prevented program implementation.ConclusionThe model improved our understanding of program implementation in health care systems and informed the creation of a toolkit to guide UTS implementation, optimization, and changes. Our findings and toolkit may serve as a use case to increase the successful implementation of other complex precision health programs.