bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE INFLUENCE OF TEACHER COMPETENCE, LEARNING RESOURCES, AND THE UTILIZATION OF SCIENCE AND TECHNOLOGY ON SOCIAL STUDIES LEARNING OUTCOMES
Authors: Suyanto Roni , Dul Aji Sudi , Fauzia Putra Dwi 
Published: December 2024

This study aims to analyze the influence of teacher competence, learning resources, and utilization of science and technology on student learning outcomes in Social Sciences (IPS) subjects at SDN Gugus IV, Maron District, Probolinggo Regency. The research method used is quantitative, data collection techniques are carried out by giving questionnaires to samples. The population of this study was students at SDN Gugus IV totaling 595, with a sample of 114 students selected. The data collection instrument was a questionnaire for the variables of teacher competence, learning resources, utilization of science and technology on student learning outcomes at SDN Gugus IV Maron, Maron District. The method used in this study is a survey method with Teacher Competence (X1), Learning Resources (X2), and Utilization of Science and Technology (X3) while the dependent variable is Learning Outcomes (Y). The results of data analysis obtained multiple linear regression of .000b with a significance of 0.05. This figure of 0.000 is smaller than alpha of 0.05. Thus it can be said that the influence of X1, X2, and X3 on Y is significant. In other words, student learning outcomes are a reflection of teacher competence, learning resources, utilization of science and technology, towards good student learning outcomes in student learning taken by students. Based on the description presented, a conclusion can be drawn that with teacher competence that is in accordance with educational standards, the available learning resources are sufficient, and the utilization of science and technology by competent teachers can improve student learning outcomes at SDN Gugus IV, Maron District, Probolinggo Regency.

Keywords: Teacher Competence, Learning Resources, Utilization of Science and Technology, Learning Outcomes.
The Evolving E-Cigarette: A Comparison Narrative of Cigarette Smoke and E-Cigarette Vapour on Sleep
Authors: Kannan Swetha 
Published: December 2024

Recent development of ‘e-cigarettes’ has increased the utilization by the common population, under the assumption of it being a safer alternative compared to conventional cigarettes. However, the harmful biological effects of e-cigarettes, or most commonly called vaping, are still not clear. This review aims to highlight the effect of conventional cigarettes on one’s sleeping patterns and quality. The studies reported in this review were collected from the databases that included PubMed, ScienceDirect, Hindawi, ResearchGate, and AHA journals from 1994-2022. Studies that focussed on the effects of smoking on other aspects of one’s health. Separate literature searches were conducted to analyse sleep quality among people that smoked cigarettes and people who used a vape. Literature reviews showed cigarette smoking caused a reduction in sleep quality and also an increased risk of sleep-related disorders. A review of articles concerning the association between vape and sleep also showed similar results, with vape users reporting shortened and poorer sleep quality compared to non-users. Data from this article can prove useful in shedding light on the deleterious impact of vape on sleep and overall general health, as the common notion of e-cigarettes being an acceptable and safe substitute is widely practiced among the younger population.
Development and mechanical characterization of eggshell bio-filler based hybrid composites
Authors: Khan Afroz , Naveen Kumar B. K. , Anand K. J. , Ashoka E. , Hareesha G. 
Published: December 2024

Hybridization of natural fiber composite by incorporating waste- derived fillers has been identified as a promising sustainable technique to develop environmentally friendly and economical composites with enhanced mechanical properties. This study explores the mechanical performance of hybrid bamboo-epoxy composites incorporated with bio filler derived from waste chicken eggshells. Compression molding was employed to develop unfilled and eggshell powder filled bamboo composites by varying eggshell content (2, 4, and 6 wt%) while maintaining constant bamboo fiber wt%. Composites were tested for mechanical properties by performing tensile test, flexural test, and impact test per ASTM standards. Results indicated that eggshell filler inclusion significantly modifies the tensile, flexural, and impact strength properties of base bamboo composite. Adding eggshell filler enhanced tensile and flexural properties which was attributed to improved interfacial bonding and efficient stress transfer. Optimal filler was achieved for composites with 4 wt % eggshell exhibiting 13.5% improvement in tensile strength and 16.4% improvement in flexural strength. While reduction in impact strength observed was attributed to incorporation of inorganic eggshell filler which mainly consists of CaCo3 content. The fractography studies revealed the improved fiber-matrix interaction with the inclusion of filler, reduced fiber pullouts, and failure by fiber breakage supporting the observed experimental results.
The Role of Customs Taxes in the Development of the Industrial Sector in Iraq for the period (2004-2022)
Authors: Niaz Kamel Asseel , Abdul Jabbar Ahmed Dawood Abdul Jabbar Ahmed 
Published: December 2024

Purpose: The impact of customs taxes in supporting and protecting the domestic product and domestic industry.
Conceptual framework: The paper dealt with the study of the role of customs taxes in the development of the industrial sector in Iraq, and the conceptual and theoretical framework of the industrial sector.
Design /methodology /methodology: We analyzed the role of customs taxes in the development of the industrial sector in Iraq during the period 2004 - 2022.
Results: The study resulted in a set of results, most important of which lies in that the volume of customs tax revenues is low, and that's why that the Iraqi economy is considered as a rentier economy because it mainly depends on the export of oil as a result of the weakness of customs tax revenues being deemed as a financial resource for the general budget in Iraq owing to the widespread financial and administrative corruption in most joints of the tax system, and the weak flexibility of the tax apparatus.
The paper, the practical and social implications: The paper Contributes to clarifying the role of customs taxes in the development of the industrial sector.
Originality/value: The results of this study showed that the number of publications related to customs taxes and their role in the development of the industrial sector is insufficient, so our research contributed to bridge the research gap between customs taxes and the industrial sector.
The Analysis of The Relationship Between Monetary Financing and the General Budget in the United States from 2008 - 2022
Authors: Dadoosh Ali Abdulkadhim , Buraihi Dr.Faris Kareem 
Published: December 2024

ان التمويل النقدي سياسة جديدة من المناقشات الاقتصادية والسياسية والمتعلقة بتمويل الانفاق الحكومي ، اذ انها تتعلق بشأن شرعية البنوك المركزية في الاقتصادات الليبرالية والنامية ، وحتى عام 2008 كان النظر الى الضرائب (النفط في الدول الريعية) واصدار الديون وتجاهل التمويل النقدي طريقة معقولة لفهم توازن الموازنة العامة – او تمويل العجز – حيث قامت الحكومات بتمويل نفسها اما عن طريق فرض الضرائب في الوقت الحاضر او عن طريق الاقتراض بشكل تقليدي ثم السداد من ايرادات الضريبة المستقبلية او عن طريق الفوائض المالية المتحققة ازاء ارتفاع اسعار النفط في الاسواق العالمية، لكن الامر اختلف بعد عام 2008 وذلك حين لجات البنوك المركزية الى استخدام التمويل النقدي كسياسة غير مسبوقة ، واصدرت مبالغ مالية كبيرة لتحفيز الاقتصادات المتأثرة بالأزمات للمواجهة . وكان هدف الدراسة التعرف على التمويل النقدي كسياسة تم فرضها من قبل الحكومات على البنوك المركزية لتمويل حجم النفقات العامة بحجة مواجهة الازمات التي تحدث بين الحين والآخر كما ان الدراسة تهدف أيضا الى بيان العلاقة بين التمويل النقدي كأداة متبعة من قبل البنك المركزي وتأثيرها على المتغيرات الاقتصادية الكلية، اذ ان لجوء الحكومة الامريكية الى سياسة التمويل النقدي ادى الى حدوث التضخم وارتفاع في حجم الدين القومي خلال مدة الدراسة، وقد توصل البحث الى استنتاج بان الحكومة الامريكية تلجا في تسييل عجز الموازنة العامة الى اقتراض الأموال عن طريق بيع حوالات الخزينة والسندات والأوراق المالية الأخرى الى بنك الاحتياطي الفيدرالي بالتالي ان الدين العام قد تراكم على الحكومة مع الفوائد المرتبطة به المستحقة للمستثمرين الذين اشتروا هذه الأوراق المالية
Strategic Thinking and Its Impact on Organizational Compatibility: An Analytical Study In The Iraqi Media Network
Authors: Naeem Hamish Fatima , Mohsen Salman Saadoun 
Published: December 2024

Purpose: This research aims to achieve the most critical objective: to reveal the relationship between strategic thinking and organizational compatibility in the Iraqi Media Network.
Theoretical Framework: In light of what researchers (Srivastava, S., & D’Souza, 2021) and (Nafei, 2017)have stated, this study provides practical guidelines for improving strategic thinking in the face of challenges and difficulties to enhance organizational compatibility.
Design/Methodology/Approach: The study aimed to analyze the data of employees in the Iraqi Media Network (2024) using strategic thinking and its dimensions (organizational thinking, processing divergent ideas, contemplation) on the impact of organizational compatibility and its dimensions (organizational loyalty, organizational similarity, organizational membership or affiliation).
Research Implications: The results confirm the existence of a statistically significant relationship between strategic thinking and organizational compatibility.
Originality/Value: This study seeks to bridge the knowledge gap by analyzing and identifying the essential skills and qualities that contribute to developing strategic thinking, enhancing organizational alignment, and applying these skills in different work environments to achieve better organizational performance.
Педагогічні умови реалізації міждисциплінарних зв’язків у професійній підготовці студентів фахових коледжів із застосуванням ІКТ
Authors: Боско Наталя 
Published: December 2024

Процес професійної підготовки конкурентоспроможних фахівців у мінливому глобалізованому світі потребує застосування інтегрованих підходів та реалізації міждисциплінарних зв’язків. Для цього необхідно виокремити педагогічні умови, що забезпечать успішність впровадження міждисциплінарності у освітній процес закладів фахової передвищої освіти із застосуванням ІКТ.
Вивчення сутності поняття «педагогічна умова» дозволило з’ясувати, що у контексті реалізації міждисциплінарних зв’язків, педагогічні умови – це агенти позитивного впливу на процес реалізації міждисциплінарних зв’язків під час професійної підготовки здобувачів. Педагогічні умови є системою науково обґрунтованих заходів, запровадження яких сприятиме підвищенню рівня та якості професійної підготовки студентів фахових коледжів. До таких умов належать: 1) готовність здобувачів та викладачів до реалізації міждисциплінарних зв’язків за допомогою ІКТ; 2) використання технологічного підходу, зокрема актуальних його елементів, таких як доступ до інформації, інтерактивне навчання та індивідуалізоване, онлайн навчання і дистанційна освіта, імерсивні технології, штучний інтелект, мобільні технології та інше; 3) застосування STEM-підходу до процесу освіти, орієнтованого на забезпечення єдності природничих та професійних дисциплін.
Для перевірки зазначених педагогічних умов та ефективності методики реалізації міждисциплінарних зв’язків під час професійної підготовки здобувачів було створено та апробовано професійно орієнтований елективний дистанційний курс «STEM для майбутніх фахівців», доповнений сучасними можливостями ІКТ, зокрема симуляціями, датчиками смартфонів, сервісами для спільної роботи, засобами оцінювання та чат-ботами. Результати дослідження його ефективності (із використанням коефіцієнта рангової кореляції Спірмена), дозволили підтвердити гіпотезу про те, що проходження елективного курсу сприяє підвищенню рівня професійної компетентності, яка буде продемонстрована під час вивчення пропедевтичної фахової дисципліни «Технології». Водночас, було зафіксовано неоднорідність результатів експериментальних груп різних спеціальностей, що розкриває перспективи для подальших досліджень та свідчить про необхідність розробки додаткових універсальних підходів до реалізації міждисциплінарних зв’язків у професійній підготовці студентів.
Lotus seed (Nelumbinis semen) extract: anticancer potential and chemoprofiling by in vitro, in silico and GC-MS studies
Authors: Mallela Vijaya Jyothi , Rudrapal Mithun , Prasanth D. S. N. B. K. , Pasala Praveen Kumar , Bendale Atul R. , Bhattacharya Soumya , Aldosari Sahar M. , Khan Johra 
Published: December 2024

Lotus seeds, also known as Nelumbinis semen, has been utilized for over 7,000 years as vegetable, functional food and medicine. In this study, we primarily investigated the anticancer effects of lotus seed extracts, particularly of the methanolic extract (MELS) on cell proliferation inhibition, apoptosis induction and cell cycle arrest in ovarian cancer cell lines. Further, we studied the phytochemical composition of the MELS by gas chromatography-mass spectrometry (GC-MS) analysis. Additionally, molecular docking was performed in order to substantiate the in vitro anticancer effect by in silico inhibitory study of human survivin protein. Our in vitro study demonstrated significant inhibition of SKOV3 (IC50: 79.73 ± 0.91), A2780 (IC50: 100.18 ± 2.42), SKOV3-CisR (IC50: 115.87 ± 2.2) and A2780-CisR (IC50: 138.86 ± 2.46) cells by MELS, compared to acetone, petroleum ether, n-hexane extracts, and the standard drug, cisplatin. Furthermore, MELS resulted in a substantial increase in apoptosis cell count to 78% in A2780-CisR cells and 82% in SKOV3-CisR cells, whereas a significant reduction in the G1 and G2/M phases of cells treated with MELS when compared to the control group. To identify the potential phytocompounds present in the MELS, we conducted GC-MS analysis, which led to the identification of 14 compounds. Molecular docking analysis revealed that oleic acid, stigmast-5-en-3-ol, phytol and glyceryl linolenate exhibited remarkable binding affinities of −6.1, −5.9, −5.8 and −5.6 kcal/mol, respectively against survivin. Our findings suggest that certain phytochemicals presented above found in MELS may have therapeutic potential for management of ovarian cancer.
A two-sample Mendelian randomization study reveals the causal effects of statin medication on gut microbiota abundance in the European population
Authors: Zhou Peng , Qiu Chen , Zhuang Zequn , Shi Kaihang , Yang Zhihui , Ding Yuyan , Qu Huiheng , Xia Jiazeng 
Published: December 2024

BackgroundObservational studies have reported changes in gut microbiota abundance caused by long-term statin medication therapy. However, the causal relation between statin medication and gut microbiota subsets based on genetic variants remains unclear.MethodsWe used genome-wide association study (GWAS) data on statin medication from the FinnGen database and gut microbiota abundance GWAS data from the IEU OpenGWAS project. A Mendelian randomization (MR) analysis was conducted to evaluate the causal effect of statin medication on gut microbiota abundance using the inverse variance weighting (IVW) method, MR-Egger regression, and weighted median approach. Meanwhile, heterogeneity and pleiotropy analyses were also undertaken in this study.ResultsStatin medication was negatively correlated with five species of gut microbiota abundance: Parabacteroides (BetaIVW = −0.2745, 95% CI = (−0.4422, −0.1068), and PIVW = 0.0013), Ruminococcaceae UCG-009 (BetaIVW = −0.1904, 95% CI = (−0.3255, −0.0553), and PIVW = 0.0057), Coprococcus 1 (BetaIVW = −0.1212, 95% CI = (−0.2194, −0.0231), and PIVW = 0.0154), Ruminococcaceae UCG-010 (BetaIVW = −0.1149, 95% CI = (−0.2238, −0.0060), and PIVW = 0.0385), and Veillonellaceae (BetaIVW = −0.0970, 95% CI = (−0.2238, 0.0060), and PIVW = 0.0400) and positively correlated with one species of gut microbiota: Desulfovibrio (BetaIVW = 0.2452, 95% CI = (0.0299, 0.4606), and PIVW = 0.0255). In addition, no significant heterogeneity or pleiotropy was detected in the abovementioned gut microbiota.ConclusionThis Mendelian randomization analysis indicates a causal relationship between statin medication and six gut microbiota species. These findings may provide new strategies for health monitoring in populations taking long-term statin medications.
Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma
Authors: Xiang Huihui , Kasajima Rika , Azuma Koichi , Tagami Tomoyuki , Hagiwara Asami , Nakahara Yoshiro , Saito Haruhiro , Igarashi Yuka , Wei Feifei , Ban Tatsuma , Yoshihara Mitsuyo , Nakamura Yoshiyasu , Sato Shinya , Koizume Shiro , Tamura Tomohiko , Sasada Tetsuro , Miyagi Yohei 
Published: December 2024

BackgroundStudies have shown that tumor cell amino acid metabolism is closely associated with lung adenocarcinoma (LUAD) development and progression. However, the comprehensive multi-omics features and clinical impact of the expression of genes associated with amino acid metabolism in the LUAD tumor microenvironment (TME) are yet to be fully understood.MethodsLUAD patients from The Cancer Genome Atlas (TCGA) database were enrolled in the training cohort. Using least absolute shrinkage and selection operator Cox regression analysis, we developed PTAAMG-Sig, a signature based on the expression of tumor-specific amino acid metabolism genes associated with overall survival (OS) prognosis. We evaluated its predictive performance for OS and thoroughly explored the effects of the PTAAMG-Sig risk score on the TME. The risk score was validated in two Gene Expression Omnibus (GEO) cohorts and further investigated against an original cohort of chemotherapy combined with immune checkpoint inhibitors (ICIs). Somatic mutation, chemotherapy response, immunotherapy response, gene set variation, gene set enrichment, immune infiltration, and plasma-free amino acids (PFAAs) profile analyses were performed to identify the underlying multi-omics features.ResultsTCGA datasets based PTAAMG-Sig model consisting of nine genes, KYNU, PSPH, PPAT, MIF, GCLC, ACAD8, TYRP1, ALDH2, and HDC, could effectively stratify the OS in LUAD patients. The two other GEO-independent datasets validated the robust predictive power of PTAAMG-Sig. Our differential analysis of somatic mutations in the high- and low-risk groups in TCGA cohort showed that the TP53 mutation rate was significantly higher in the high-risk group and negatively correlated with OS. Prediction from transcriptome data raised the possibility that PTAAMG-Sig could predict the response to chemotherapy and ICIs therapy. Our immunotherapy cohort confirmed the predictive ability of PTAAMG-Sig in the clinical response to ICIs therapy, which correlated with the infiltration of immune cells (e.g., T lymphocytes and nature killer cells). Corresponding to the concentrations of PFAAs, we discovered that the high PTAAMG-Sig risk score patients showed a significantly lower concentration of plasma-free α-aminobutyric acid.ConclusionIn patients with LUAD, the PTAAMG-Sig effectively predicted OS, drug sensitivity, and immunotherapy outcomes. These findings are expected to provide new targets and strategies for personalized treatment of LUAD patients.
NECTIN-4-redirected T cell Antigen Coupler T cells bearing CD28 show superior antitumor responses against solid tumors
Authors: Wei Cheng , Huang Xin , Xu Tianlong , Fang Yinan , Wang Fabao , He Qiaolin , Zhang Peiyuan , Yu Qianjin , Zhang Ying , Zheng Binjiao , Gao Yue , Chen Yongping , Zhuge Qichuan , Zhao Ai , Gao Jimin , Jiang Jinhong 
Published: December 2024

IntroductionT cell Antigen Coupler (TAC) T cells harness all signaling subunits of endogenous T cell receptor (TCR) to trigger T-cell activation and tumor cell lysis, with minimal release of cytokines. Some of the major obstacles to cellular immunotherapy in solid tumors include inefficient cell infiltration into tumors, lack of prolonged cellular persistence, and therapy-associated toxicity.MethodsTo boost the cytotoxic potential of TAC-T cells against solid tumors, we generated a novel NECTIN-4-targeted TAC-T variant, NECTIN-4 TAC28-T, which integrated the co-stimulatory CD28 cytoplasmic region, and compared the anti-tumor activities between NECTIN-4 TAC-T cells and NECTIN-4 TAC28-T cells in vitro and vivo.ResultsWe demonstrated NECTIN-4 TAC28-Tcells could be effectively activated by NECTIN-4 protein-coated magnetic beads (NECTIN-4-beads), and further revealed that the incorporated CD28 co-stimulatory domain enhanced their activation and proliferation capabilities. Notably, NECTIN-4 TAC28-T cells exhibited better anti-tumor effects both in vitro and in vivo than the original NECTIN-4 TAC-T cells.DiscussionOur data highlighted that NECTIN-4 TAC28-T cells may represent a promising, safe and effective cell therapy for NECTIN-4-overexpressing solid tumors.
Circulating extracellular vesicles and neutrophil extracellular traps contribute to endothelial dysfunction in preeclampsia
Authors: Ramos Alex , Youssef Lina , Molina Patricia , Torramadé-Moix Sergi , Martinez-Sanchez Julia , Moreno-Castaño Ana Belen , Blasco Miquel , Guillén-Olmos Elena , De Moner Blanca , Pino Marc , Tortajada Marta , Camacho Marta , Borrell Maria , Crovetto Francesca , Ramirez-Bajo Maria Jose , Ventura-Aguiar Pedro , Banon-Maneus Elisenda , Rovira Jordi , Escolar Gines , Carreras Enric , Gratacos Eduard , Diaz-Ricart Maribel , Crispi Fatima , Palomo Marta 
Published: December 2024

BackgroundPreeclampsia (PE) is a pregnancy complication characterized by hypertension, proteinuria, endothelial dysfunction, and complement dysregulation. Placenta-derived extracellular vesicles (EVs), necessary in maternal–fetal communication, might contribute to PE pathogenesis. Moreover, neutrophil extracellular traps (NETs) play a pathogenic role in other complement-mediated pathologies, and their contribution in PE remains unexplored.Materials and methodsEVs were isolated from PE (peEVs) and normotensive pregnant women sera. NETs were obtained incubating donor-pre-activated neutrophils with PE or control sera. Microvascular (HMEC) endothelial cells (ECs) were incubated with PE or control sera with or without (depleted sera) EVs or NETs, to assess changes in VCAM-1, ICAM-1, VE-cadherin, eNOS, VWF, ROS, and C5b-9 deposits. Results were expressed as fold increase vs. control.ResultsVWF, VCAM-1, and ROS expression was significantly higher in cells exposed to PE sera vs. control (12.3 ± 8.1, 3.6 ± 2.3, and 1.8 ± 0.2, respectively, p &lt; 0.05), though significantly lower in cells exposed to depleted PE (dPE) sera (6.1 ± 2.7, 0.7 ± 0.6, and 1.2 ± 0.1, respectively, vs. control, p &lt; 0.05). EC exposure to depleted control sera supplemented with peEVs (dC+peEVs) significantly increased VWF, VCAM-1, and ROS compared to non-supplemented sera (4.5 ± 0.3, 2.8 ± 2.0, and 1.4 ± 0.2, respectively, p &lt; 0.05). ICAM-1, VE-cadherin, and C5b-9 did not differ among groups. ECs incubated with PE-NETs increased VWF and VCAM-1 and decreased VE-cadherin expression vs. control (4 ± 1.6, 5.9 ± 1.2, and 0.5 ± 0.1, respectively, p &lt; 0.05), and notably increased C5b-9 deposit (7.5 ± 2.9, p &lt; 0.05). ICAM-1 and ROS did not differ.ConclusionsBoth circulating EVs and NETs from PE pregnant women exhibit a deleterious effect on ECs. Whereas EVs trigger a pro-oxidant and proinflammatory state, NETs potentiate the activation of the complement system, as already described in PE.