bluuebunny/crossref_metadata_2025_split huggingface dataset:
Who is the boss? Identifying key roles in telecom fraud network via centrality-guided deep random walk
Authors: Chang Yi-Chun , Lai Kuan-Ting , Chou Seng-Cho T. , Chiang Wei-Chuan , Lin Yuan-Chen 
Published: November 2020

PurposeTelecommunication (telecom) fraud is one of the most common crimes and causes the greatest financial losses. To effectively eradicate fraud groups, the key fraudsters must be identified and captured. One strategy is to analyze the fraud interaction network using social network analysis. However, the underlying structures of fraud networks are different from those of common social networks, which makes traditional indicators such as centrality not directly applicable. Recently, a new line of research called deep random walk has emerged. These methods utilize random walks to explore local information and then apply deep learning algorithms to learn the representative feature vectors. Although effective for many types of networks, random walk is used for discovering local structural equivalence and does not consider the global properties of nodes.Design/methodology/approachThe authors proposed a new method to combine the merits of deep random walk and social network analysis, which is called centrality-guided deep random walk. By using the centrality of nodes as edge weights, the authors’ biased random walks implicitly consider the global importance of nodes and can thus find key fraudster roles more accurately. To evaluate the authors’ algorithm, a real telecom fraud data set with around 562 fraudsters was built, which is the largest telecom fraud network to date.FindingsThe authors’ proposed method achieved better results than traditional centrality indices and various deep random walk algorithms and successfully identified key roles in a fraud network.Research limitations/implicationsThe study used co-offending and flight record to construct a criminal network, more interpersonal relationships of fraudsters, such as friendships and relatives, can be included in the future.Originality/valueThis paper proposed a novel algorithm, centrality-guided deep random walk, and applied it to a new telecom fraud data set. Experimental results show that the authors’ method can successfully identify the key roles in a fraud group and outperform other baseline methods. To the best of the authors’ knowledge, it is the largest analysis of telecom fraud network to date.
Effect of online hotel reviews on the relationship between defender and prospector strategies and management controls
Authors: Bortoluzzi Daiane Antonini , Lunkes Rogério João , Santos Edicreia Andrade dos , Mendes Alcindo Cipriano Argolo 
Published: November 2020

Purpose
This study aims to analyze the effect of online hotel reviews on the relationship between defender and prospector strategies and management control system (MCS) design.

Design/methodology/approach
To conduct the study, this paper administered a questionnaire to large Brazilian hotels and analyzed data from 204 hotels using structural equation modeling and fuzzy logic.

Findings
The main results show that online hotel reviews have a positive and significant effect on the relationship between prospector strategy and personnel and action control. In contrast, online reviews have a negative effect on the relationship between defender strategy and personnel, action and results controls. Thus, it is confirmed that online reviews change the relationship between strategy and MCS design.

Practical implications
The results show that online reviews play an important role in the decisions of hotel managers regarding MCS design. Customer demand evaluations, which are regularly available online on analysis websites, help managers adapt the MCS design, ensuring that their actions are aligned with the adopted strategy. This study adds to previous studies by showing that hotel managers use the information from customer evaluations to improve their performance.

Originality/value
The management literature based on the contingency theory indicates that strategy is a variable that affects MCS design. This study extends this discussion by indicating that online reviews, specifically in the hotel industry, can also be a determining factor in defining management controls. In addition, this paper points out that OHR impacts differently, depending on the strategy used and the type of management control.
Two decades of international branch campus development, 2000–2020: a review
Authors: Wilkins Stephen 
Published: November 2020

PurposeThe research aims to assess the achievements and challenges of international branch campuses (IBCs) to date and to consider how IBC development may progress in the future.Design/methodology/approachThe article presents a review of the scholarly and grey literatures on IBCs. The commentary and discussion is structured around the objectives, perspectives and experiences of three key stakeholder groups, namely the institutions that own IBCs, students and host countries.FindingsSome IBCs have failed to achieve their student recruitment and financial targets, while others have been successful, often expanding and moving into new, larger, purpose-built campuses. In the last few years, several countries have announced their intention to become a transnational education hub, or at least to allow the establishment of IBCs. It may be reasonable to assume that when there is demand for a product, supply will eventually follow. IBCs will survive and prosper as long as they provide benefits to each of their main stakeholder groups (i.e. students, institutions and governments), and as long as the local demand for higher education places exceeds the total supply.Originality/valueThe article provides a comprehensive and up-to-date review of IBC developments and research during the period 2000–2020. The findings and conclusions will be of interest to both researchers and practitioners.
Aphicidal activity of Bacillus thuringiensis strain AH‐2 against cotton aphid (Aphis gossypii)
Authors: Ajuna Henry B. , Kim Iksoo , Han Yeon Soo , Maung Chaw Ei Htwe , Kim Kil Yong 
Published: November 2020

AbstractBacillus thuringiensis (Bt) is the most commercialized entomopathogenic species. However, the low efficacy against notorious sap‐sucking Hemipteran pests and the high costs of production, reduce the applicability of Bt biopesticides. In this context, B. thuringiensis AH‐2 (Bt‐2) isolated from soil was found to release parasporal inclusions and aphicidal activity. Bt‐2 showed optimal growth at pH 8 and 30°C in tryptic soy broth (TSB) and maintained normal growth when cultured in cost‐effective test media, pink brown (PB), supplemented with either glucose (PBG) or sucrose (PBS). To study aphicidal activity against cotton aphid (Aphis gossypii), Bt‐2 and a commercial B. thuringiensis subspecies kurstaki (Btk) were used. Using third nymph (3 N) instars, treatment with Bt‐2 caused 70.2, 78.1 and 88.4% mortality at 10, 25 and 50% culture concentrations, respectively. Similarly, Btk resulted in 79.9, 80.4 and 92.9% mortality at 10, 25 and 50%, respectively. When cultured in TSB, PBG and PBS media, Bt‐2 culture (50%) resulted in 85.9, 82.9 and 82.2% 3 N mortality, respectively. Equally, Btk caused a mortality of 79.9, 78.9 and 78.9% in TSB, PBG and PBS, respectively. Bt‐2 exerted a notably higher aphicidal efficacy at 24 h after treatment compared to Btk, especially at low concentration. Moreover, both Bt strains significantly suppressed adult fecundity compared to control. At 50% culture concentration, Bt‐2 and Btk suppressed adult fecundity by 98.3 and 91.1%, respectively. Our result demonstrates a strong aphicidal efficacy of Bt‐2, and its potential production using cost‐effective PB medium.
Prognostic and clinicopathological roles of programmed death‐ligand 1 (PD‐L1) expression in thymic epithelial tumors: A meta‐analysis
Authors: Koh Hyun Min , Jang Bo Gun , Lee Hyun Ju , Hyun Chang Lim 
Published: November 2020

BackgroundProgrammed death‐ligand 1 (PD‐L1) is one of the immune checkpoint proteins, and plays an important role in the progression and microenvironment of cancer. PD‐L1 expression has been associated with poor survival in many cancers. Several studies have also shown an association between PD‐L1 expression and the prognosis of patients with thymic epithelial tumors (TETs). In this study, we systematically evaluated the prognostic and clinicopathological roles of PD‐L1 expression in TETs.MethodsWe searched the literature through PubMed, Embase and Cochrane library and chose the eligible studies, and subsequently performed a meta‐analysis to evaluate the prognostic and clinicopathological roles of PD‐L1 expression in TETs.ResultsSix of the 75 articles found in the literature were selected. PD‐L1 expression was significantly related to unfavorable overall survival (hazard ratio 1.52, 95% confidence interval [CI]: 1.01–2.30, P = 0.046) in TETs. PD‐L1 expression was significantly associated with male gender (odds ratio [OR] 1.55, 95% CI: 1.08–2.22, P = 0.017) and higher Masaoka stage (OR 3.93, 95% CI: 2.44–6.32, P < 0.001).ConclusionsPD‐L1 expression was correlated with unfavorable prognosis in TETs, indicating PD‐L1 expression could help determine the prognosis of TET patients.
Clinical characteristics and risk factors for in‐hospital mortality of lung cancer patients with COVID‐19: A multicenter, retrospective, cohort study
Authors: Nie Lei , Dai Kai , Wu Jiang , Zhou Xia , Hu Junjun , Zhang Chao , Zhan Yan , Song Yu , Fan Wen , Hu Zhimin , Yang Hongshan , Yang Qiong , Wu Dongde , Li Fajiu , Li Daoyuan , Nie Rui 
Published: November 2020

BackgroundData on clinical, laboratory, and radiographic characteristics and risk factors for in‐hospital mortality of lung cancer patients with COVID‐19 are scarce. Here, we aimed to characterize the early clinical features of lung cancer patients with COVID‐19 and identify risk factors associated with in‐hospital mortality.MethodsAll consecutive lung cancer patients with laboratory‐confirmed COVID‐19 admitted to 12 hospitals in Hubei province, China, from 3 January to 6 May 2020 were included in the study. Patients without definite clinical outcomes during the period were excluded. Data on initial clinical, laboratory and radiographic findings were compared between survivors and nonsurvivors. Univariable and multivariable logistic regression analyses were used to explore the risk factors associated with in‐hospital mortality.ResultsOf the 45 lung cancer patients (median [interquartile range] age, 66 [58–74] years; 68.9% males) included, 34 (75.6%) discharged and 11 (24.4%) died. Fever (73.3%) and cough (53.3%) were the dominant initial symptoms, and respiratory symptoms were common. Lung cancer patients also presented atypical appearances of COVID‐19. In the multivariable analysis, prolonged prolongation prothrombin time (PT) (OR = 2.1, 95% CI: 1.00–4.41, P = 0.0497) and elevated high sensitivity cardiac troponin I (hs‐TNI) (OR = 7.65, 95% CI: 1.24–47.39, P = 0.0287) were associated with an increased risk of in‐hospital mortality.ConclusionsLung cancer patients with COVID‐19 have high in‐hospital mortality. Prolonged PT and elevated hs‐TNI are independent risk factors for in‐hospital mortality of lung cancer patients with COVID‐19.Key pointsSignificant findings of the study
Lung cancer patients with COVID‐19 have atypical early symptoms and imaging features.
The prolonged prothrombin time and elevated high sensitivity cardiac troponin I are independent risk factors for in‐hospital mortality of lung cancer patients with COVID‐19.
What this study addsThis study characterizes the early clinical features of lung cancer patients with COVID‐19 in China, and identifies the risk factors associated with in‐hospital mortality of lung cancer patients with COVID‐19.
Sweet turning bitter: Carbohydrate sensing of complement in host defence and disease
Authors: Hevey Rachel , Pouw Richard B. , Harris Claire , Ricklin Daniel 
Published: November 2020

The complement system plays a major role in threat recognition and in orchestrating responses to microbial intruders and accumulating debris. This immune surveillance is largely driven by lectins that sense carbohydrate signatures on foreign, diseased and healthy host cells and act as complement activators, regulators or receptors to shape appropriate immune responses. While carbohydrate sensing protects our bodies, misguided or impaired recognition can contribute to disease. Moreover, pathogenic microbes have evolved to evade complement by mimicking host signatures. While complement is recognized as a disease factor, we only slowly start to appreciate the role of carbohydrate interactions in the underlying processes. A better understanding of complement's sweet side will contribute to a better description of disease mechanisms and enhanced diagnostic and therapeutic options. This review introduces the key components in complement‐mediated carbohydrate sensing, discusses their role in health and disease, and touches on the potential effects of carbohydrate‐related disease intervention.Linked ArticlesThis article is part of a themed issue on Canonical and non‐canonical functions of the complement system in health and disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issuetoc
dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells
Authors: Yokogawa Tatsushi , Yano Wakako , Tsukioka Sayaka , Osada Akiko , Wakasa Takeshi , Ueno Hiroyuki , Hoshino Takuya , Yamamura Keisuke , Fujioka Akio , Fukuoka Masayoshi , Ohkubo Shuichi , Matsuo Kenichi 
Published: November 2020

AbstractDeficiency in DNA repair proteins confers susceptibility to DNA damage, making cancer cells vulnerable to various cancer chemotherapies. 5‐Fluorouracil (5‐FU) is an anticancer nucleoside analog that both inhibits thymidylate synthase (TS) and causes DNA damage via the misincorporation of FdUTP and dUTP into DNA under the conditions of dTTP depletion. However, the role of the DNA damage response to its antitumor activity is still unclear. To determine which DNA repair pathway contributes to DNA damage caused by 5‐FU and uracil misincorporation, we examined cancer cells treated with 2ʹ‐deoxy‐5‐fluorouridine (FdUrd) in the presence of TAS‐114, a highly potent inhibitor of dUTPase that restricts aberrant base misincorporation. Addition of TAS‐114 increased FdUTP and dUTP levels in HeLa cells and facilitated 5‐FU and uracil misincorporation into DNA, but did not alter TS inhibition or 5‐FU incorporation into RNA. TAS‐114 showed synergistic potentiation of FdUrd cytotoxicity and caused aberrant base misincorporation, leading to DNA damage and induced cell death even after short‐term exposure to FdUrd. Base excision repair (BER) and homologous recombination (HR) were found to be involved in the DNA repair of 5‐FU and uracil misincorporation caused by dUTPase inhibition in genetically modified chicken DT40 cell lines and siRNA‐treated HeLa cells. These results suggested that BER and HR are major pathways that protect cells from the antitumor effects of massive incorporation of 5‐FU and uracil. Further, dUTPase inhibition has the potential to maximize the antitumor activity of fluoropyrimidines in cancers that are defective in BER or HR.
Is it really possible to compensate for colour blindness with a filter?
Authors: Valero Eva M. , Huertas Rafael , Martínez‐Domingo Miguel Ángel , Gómez‐Robledo Luis , Hernández‐Andrés Javier , Nieves Juan Luis , Romero Javier 
Published: November 2020

AbstractIn the last 2 decades, there has been a resurgence of the idea that passive aids such as colour filters can be an effective solution to compensate colour vision deficiency (CVD) or improve colour vision for subjects with CVD. We examine briefly the scientific evidence that has to date been gathered to study the reliability of these aids. In the light of our experience working in this field, we reflect on several related issues: why this question has not been elucidated before, how a filter would have to be designed for a specific task, and the importance of developing a personalised colour space for subjects with CVD to gain some insight into the effect of aids.
Assessment of Target Engagement in a First‐in‐Human Trial with Sinbaglustat, an Iminosugar to Treat Lysosomal Storage Disorders
Authors: Gehin Martine , Melchior Meggane , Welford Richard W.D. , Sidharta Patricia N. , Dingemanse Jasper 
Published: November 2020

In this first‐in‐human study, the tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple oral doses of sinbaglustat, a dual inhibitor of glucosylceramide synthase (GCS) and non‐lysosomal glucosyl ceramidase (GBA2), were investigated in healthy subjects. The single‐ascending dose (SAD) and multiple‐ascending dose (MAD) studies were randomized, double‐blind, and placebo‐controlled. Single doses from 10 to 2,000 mg in men and multiple doses from 30 to 1,000 mg twice daily for 7 days in male and female subjects were investigated. Tolerability, PK, and PD data were collected up to 3 days after (last) treatment administration and analyzed descriptively. Sinbaglustat was well‐tolerated in the SAD and MAD studies, however, at the highest dose of the MAD, three of the four female subjects presented a similar pattern of general symptoms. In all cohorts, sinbaglustat was rapidly absorbed. Thereafter, plasma concentrations decreased biphasically. In the MAD study, steady‐state conditions were reached on Day 2 without accumulation. During sinbaglustat treatment, plasma concentrations of glucosylceramide (GlcCer), lactosylceramide, and globotriaosylceramide decreased in a dose‐dependent manner, reflecting GCS inhibition. The more complex the glycosphingolipid, the more time was required to elicit PD changes. After treatment stop, GlcCer levels returned to baseline and increased above baseline at lowest doses, probably due to the higher potency of sinbaglustat on GBA2 compared to GCS. Overall, sinbaglustat was welltolerated up to the highest tested doses. The PK profile is compatible with b.i.d. dosing. Sinbaglustat demonstrated target engagement in the periphery for GCS and GBA2.
Diffuse Drivers of Modern Slavery: From Microfinance to Unfree Labour in Cambodia
Authors: Natarajan Nithya , Brickell Katherine , Parsons Laurie 
Published: November 2020

ABSTRACTOver the past two decades, the global issue of modern slavery has become increasingly prominent within development thinking and practice. Efforts to address it largely focus on criminal prosecutions of immediate ‘perpetrators’, for instance those who are direct employers or middlemen. This article adds to a growing call from critical scholars to look to the structural drivers of such highly exploitative labour relations. Drawing on an unfree labour approach that views debt bondage as embedded in and reproduced by capitalist accumulation, this analysis explores the diffuse drivers of unfree labour through the experiences of indebted farmers who have migrated from rural areas to work in and around Phnom Penh as debt‐bonded brick‐kiln labourers. The study demonstrates how debt discipline in the context of unregulated microfinance lending in rural Cambodia creates the conditions for unfree labour to emerge. Evidencing links between risky lending practices and unfree labour, the article strengthens calls to understand modern slavery as unfree labour and, in doing so, highlights the failures of the UN's Sustainable Development Goal 8 and other similar policies to make these crucial connections.
Inhibition of exosomal miR‐24‐3p in diabetes restores angiogenesis and facilitates wound repair via targeting PIK3R3
Authors: Xu Yan , Ouyang Liu , He Lei , Qu Yanzhen , Han Yu , Duan Deyu 
Published: November 2020

AbstractDiabetic foot ulcer (DFU) is one of the common ailments of elderly people suffering from diabetes. Exosomes containing various active regulators have been found to play a significant role in apoptosis, cell proliferation and other biological processes. However, the effect and the underlying mechanism of action of diabetes patients derived from circulating exosomes (Dia‐Exos) on DFU remain unclear. Herein, we aim to explore the potential regulatory role of Dia‐Exos. First, we attempted to demonstrate the harmful effect of Dia‐Exos both in vivo and in vitro. miRNA‐24‐3p (miR‐24‐3p) was found enriched with Dia‐Exos. Hence, inhibition of this miRNA could partially reverse the negative effect of Dia‐Exos, thus, in ture, accelerates wound repair. Luciferase assay further verified the binding of miR‐24‐3p to the 3′‐UTR of phosphatidylinositol 3‐kinase regulatory subunit gamma (PIK3R3) mRNA and the PIK3R3 expression enhanced human umbilical vein endothelial cells functionality in vitro. Hence, the findings of this study reveal the regulatory role of Dia‐Exos in the process of wound healing and provide experimental evidence for the therapeutic effects of knocking down miR‐24‐3p in DFU treatment.
Potentials of AI in medical image analysis in Gastroenterology and Hepatology
Authors: Chen Hao , Sung Joseph J Y 
Published: November 2020

AbstractWith the advancement of artificial intelligence (AI) technology, it comes in a big wave carrying possibly huge impact in the field of medicine. Gastroenterology and hepatology, being a specialty relying much on diagnostic imaging, endoscopy, and histopathology, AI technology has promised improving the quality and consistency of care to the patients. In this review, we will elucidate the development of machine learning methods, especially the visual representation mechanism in deep learning on recognition tasks. Various AI‐image analysis applications in endoscopy, radiology, and pathology are covered in gastroenterology and hepatology and reveal the enormous potentials for AI in assisting diagnosis, prognosis, and treatment. We also discuss the promises as well as pitfalls for AI in medical image analysis and pointing out future research directions.
Comorbidities, anthropometric, demographic, and lifestyle risk factors for ulnar neuropathy at the elbow: A case control study
Authors: Mondelli Mauro , Mattioli Stefano , Vinciguerra Claudia , Ciaramitaro Palma , Aretini Alessandro , Greco Giuseppe , Sicurelli Francesco , Giorgi Stefano , Curti Stefania 
Published: November 2020

AbstractWe performed a prospective multicenter case‐control study to explore the association between ulnar neuropathy at elbow (UNE) and body and elbow anthropometric measures, demographic and lifestyle factors, and comorbidities. Cases and controls were consecutively enrolled among subjects admitted to four electromyography labs. UNE diagnosis was made on clinical and neurographic findings. The control group included all other subjects without signs/symptoms of ulnar neuropathy and with normal ulnar nerve neurography. Anthropometric measurements included weight, height, waist, hip circumferences, and external measures of elbow using a caliper. The participants filled in a self‐administered questionnaire on personal characteristics, lifestyle factors, and medical history. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) by fitting unconditional logistic regression models adjusted by center and education level. We enrolled 220 cases (males 61.8%; mean age 51.7 years) and 460 controls (47.4% males; mean age 47.8 years). At multivariable analysis, UNE was associated to male gender (OR = 2.4, 95%CI = 1.6‐3.7), smoking habits (>25 pack‐years (OR = 2.3, 95%CI = 1.3‐4.1), body mass index (OR = 1.05, 95%CI 1.01‐1.10), polyneuropathies (OR = 4.1, 95%CI 1.5‐11.5), and leaning with flexed elbow on a table/desk (OR = 1.5, 95%CI 1.0‐2.2). Cubital groove width (CGW) turned out to be negatively associated with UNE (OR = 0.80, 95%CI = 0.74‐0.85). Our study suggests that some personal factors especially anthropometric measures of the elbow may play a role in UNE pathogenesis as the measures of wrist in CTS. We demonstrated that for each millimeter of smaller CGW the risk of idiopathic UNE increases of 25%.