bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease
Authors: Amara Amy W. , Wood Kimberly H. , Joop Allen , Memon Raima A. , Pilkington Jennifer , Tuggle S. Craig , Reams John , Barrett Matthew J. , Edwards David A. , Weltman Arthur L. , Hurt Christopher P. , Cutter Gary , Bamman Marcas M. 
Published: February 2020

AbstractBackgroundSleep dysfunction is common and disabling in persons with Parkinson's Disease (PD). Exercise improves motor symptoms and subjective sleep quality in PD, but there are no published studies evaluating the impact of exercise on objective sleep outcomes. The goal of this study was to to determine if high‐intensity exercise rehabilitation combining resistance training and body‐weight interval training, compared with a sleep hygiene control improved objective sleep outcomes in PD.MethodsPersons with PD (Hoehn & Yahr stages 2–3; aged ≥45 years, not in a regular exercise program) were randomized to exercise (supervised 3 times a week for 16 weeks; n = 27) or a sleep hygiene, no‐exercise control (in‐person discussion and monthly phone calls; n = 28). Participants underwent polysomnography at baseline and post‐intervention. Change in sleep efficiency was the primary outcome, measured from baseline to post‐intervention. Intervention effects were evaluated with general linear models with measurement of group × time interaction. As secondary outcomes, we evaluated changes in other aspects of sleep architecture and compared the effects of acute and chronic training on objective sleep outcomes.ResultsThe exercise group showed significant improvement in sleep efficiency compared with the sleep hygiene group (group × time interaction: F = 16.0, P < 0.001, d = 1.08). Other parameters of sleep architecture also improved in exercise compared with sleep hygiene, including total sleep time, wake after sleep onset, and slow‐wave sleep. Chronic but not acute exercise improved sleep efficiency compared with baseline.ConclusionsHigh‐intensity exercise rehabilitation improves objective sleep outcomes in PD. Exercise is an effective nonpharmacological intervention to improve this disabling nonmotor symptom in PD. © 2020 International Parkinson and Movement Disorder Society
A compact pattern diversity MIMO antenna with enhanced bandwidth and high‐isolation characteristics for WLAN/5G/WiFi applications
Authors: Yang Ming , Zhou Jinzhi 
Published: February 2020

AbstractIn this article, a novel multiple input multiple output (MIMO) antenna with compact structure and diverse radiation patterns is designed for a wireless communication device. Four monopole antenna elements are placed orthogonally at the corner of the substrate. A decoupling structure composed of a circular patch and 4 L‐shaped branches placed counterclockwise is printed on the upper surface of the substrate to reduce coupling between antenna elements. Due to the surface current on the circular parasitic patch, which was acquired by coupling with the monopole antenna, the MIMO antenna exhibits an omnidirectional radiation pattern at low frequencies and a directional radiation pattern at high frequencies. In order to verify the accuracy of theoretical analysis and simulated results, the proposed antenna with a compact size of 30 mm × 30 mm is fabricated and measured. The measured results show that the overlapping bandwidths (S11 ≤ −10 dB) are 28.8% from 4.58 to 6.12 GHz and over 4.02 dBi gain. Furthermore, the measured results of pattern diversity are basically consistent with the simulated results, and the measured isolation is up to 15.4 dB, which suggest that the presented antenna can be applied to WLAN/5G/WiFi wireless communication.
Nutrition in Chronic Liver Disease: A Point‐of‐Care Review
Authors: Ghufran Aiman 
Published: February 2020

AbstractPatients with chronic liver disease have a very high lifetime risk of malnourishment. It has been increasingly identified in literature that the severity of liver disease affects severity of malnutrition and vice versa. The objective of this review article is to recognize the severity of complications associated with malnutrition in patients with cirrhosis and ways to overcome these obstacles.
MicroRNA Profiling in Adipose Before and After Weight Loss Highlights the Role of miR‐223‐3p and the NLRP3 Inflammasome
Authors: Macartney‐Coxson Donia , Danielson Kirsty , Clapham Jane , Benton Miles C. , Johnstone Alice , Jones Angela , Shaw Odette , Hagan Ronald D. , Hoffman Eric P. , Hayes Mark , Harper Jacquie , Langston Michael A. , Stubbs Richard S. 
Published: February 2020

ObjectiveAdipose tissue plays a key role in obesity‐related metabolic dysfunction. MicroRNA (miRNA) are gene regulatory molecules involved in intercellular and inter‐organ communication. It was hypothesized that miRNA levels in adipose tissue would change after gastric bypass surgery and that this would provide insights into their role in obesity‐induced metabolic dysregulation.MethodsmiRNA profiling (Affymetrix GeneChip miRNA 2.0 Array) of omental and subcutaneous adipose (n = 15 females) before and after gastric bypass surgery was performed.ResultsOne omental and thirteen subcutaneous adipose miRNAs were significantly differentially expressed after gastric bypass, including downregulation of miR‐223‐3p and its antisense relative miR‐223‐5p in both adipose tissues. mRNA levels of miR‐223‐3p targets NLRP3 and GLUT4 were decreased and increased, respectively, following gastric bypass in both adipose tissues. Significantly more NLRP3 protein was observed in omental adipose after gastric bypass (P = 0.02). Significant hypomethlyation of NLRP3 and hypermethylation of miR‐223 were observed in both adipose tissues after gastric bypass. In subcutaneous adipose, significant correlations were observed between both miR‐223‐3p and miR‐223‐5p and glucose and between NLRP3 mRNA and protein levels and blood lipids.ConclusionsThis is the first report detailing genome‐wide miRNA profiling of omental adipose before and after gastric bypass, and it further highlights the association of miR‐223‐3p and the NLRP3 inflammasome with obesity.
Peripheral ameloblastic carcinoma of the mandible: Report of two cases with different types
Authors: Sumita Yoshinori , I Takashi , Kawasaki Takako , Hara Masahito , Fujita Shuichi , Asahina Izumi 
Published: February 2020

AbstractPeripheral ameloblastic carcinoma is a rare odontogenic tumor that is characterized by malignant cytological features in combination with histological features of ameloblastoma. In this report, two cases of peripheral ameloblastic carcinoma of different types arising at the mandibular gingiva are presented. Both patients had marginal resection after incisional biopsy and were diagnosed as ameloblastic carcinoma according to WHO classification in 2017. However, two cases had distinct pathological features. First case had no finding suspicious of malignant transformation from benign ameloblastoma (primary type with 2005 WHO classification), while the other case showed benign ameloblastoma with malignant changes within the gingiva (secondary type with 2005 WHO classification).
Association between cell‐free DNA fetal fraction and gestational diabetes
Authors: Hopkins Maeve K. , Koelper Nathanael , Bender Whitney , Durnwald Celeste , Sammel Mary , Dugoff Lorraine 
Published: February 2020

AbstractObjectiveTo determine the association between cell‐free DNA (cfDNA) fetal fraction and gestational diabetes (GDM) in a cohort of women presenting for cfDNA screening for fetal aneuploidy.MethodsA retrospective cohort study of women with singleton pregnancies who had cfDNA screening at a single institution at 10 to 20 weeks gestation between October 2011 and October 2017. Fetal fractions were adjusted for gestational age (GA) using multiples of the median (MoM). Multivariable logistic regression was used to estimate the odds ratio (OR) of GDM controlling for potential confounders.ResultsTwo thousand six hundred twenty‐three pregnancies met criteria. Women with GDM had a lower fetal fraction (0.93 MoM vs. 1.05 MoM, P = .002). However, the association between fetal fraction and GDM was not significant after adjusting for body mass index (BMI) [OR 0.84, 95% confidence interval (CI) 0.52‐1.36; P = .48]. Since insulin resistance increases at later GAs, separate analysis on women with GA 14 to 20 weeks was performed. Again, the association between fetal fraction and GDM was not significant after adjusting for BMI, (OR 0.81, 95% CI 0.31‐2.12; P = .67).ConclusionLow or high fetal fraction of cfDNA was not associated with GDM. Although fetal fraction was lower among women diagnosed with GDM, this relationship was no longer statistically significant once maternal BMI was taken into account.
Characteristics of vascular anastomoses in monochorionic twin 587 placentas with selective intrauterine growth restriction via 89 three‐dimensional computed tomography angiography
Authors: Li Meizhi , Wang Chaoyang , Yang Yanhong , Mao Lijuan , Chen Jiawen , He Shaofu , Gou Chenyu , Zhang Xiaoling 
Published: February 2020

AbstractObjectiveTo determine the characteristics of the choriovascular anatomy, especially the potential role of arteriovenous perfusion imbalance in the pathogenesis of selective intrauterine growth restriction (sIUGR) using three‐dimensional computed tomography angiography (3D‐CTA).MethodComputed tomography angiography of the placental choriovascular tree from 15 twins with sIUGR and 15 twins without sIUGR were analyzed, and inter‐twin vascular anastomoses were compared between the placentas from these two groups. The parameters evaluated were the presence and measures of artery‐to‐artery anastomoses (AAA), vein‐to‐vein anastomoses (VVA) or artery‐to‐vein anastomoses (AVA).ResultsThe frequency of AAA, VVA, and AVA did not differ significantly between sIUGR and without sIUGR‐pairs. The area of the vein draining to the AVA in the larger twin's placenta was significantly greater in sIUGR compared to when no sIUGR was present. Based on the net cross‐sectional area difference we speculate that in sIUGR there is net flow from the smaller to the larger twin.ConclusionWe used 3D‐CTA to display the vascular anastomoses in sIUGR twin pairs, demonstrating a difference in cross‐sectional diameter of the vein draining to the AVA.
A metabolomics study of ascorbic acid‐induced in situ freezing tolerance in spinach (Spinacia oleracea L.)
Authors: Min Kyungwon , Chen Keting , Arora Rajeev 
Published: February 2020

AbstractFreeze–thaw stress is one of the major environmental constraints that limit plant growth and reduce productivity and quality. Plants exhibit a variety of cellular dysfunctions following freeze–thaw stress, including accumulation of reactive oxygen species (ROS). This means that enhancement of antioxidant capacity by exogenous application of antioxidants could potentially be one of the strategies for improving freezing tolerance (FT) of plants. Exogenous application of ascorbic acid (AsA), as an antioxidant, has been shown to improve plant tolerance against abiotic stresses but its effect on FT has not been investigated. We evaluated the effect of AsA‐feeding on FT of spinach (Spinacia oleracea L.) at whole plant and excised‐leaf level, and conducted metabolite profiling of leaves before and after AsA treatment to explore metabolic explanation for change in FT. AsA application did not impede leaf growth, instead slightly promoted it. Temperature‐controlled freeze–thaw tests revealed AsA‐fed plants were more freezing tolerant as indicated by: (a) less visual damage/mortality; (b) lower ion leakage; and (c) less oxidative injury, lower abundance of free radicals ( and H2O2). Comparative leaf metabolite profiling revealed clear separation of metabolic phenotypes for control versus AsA‐fed leaves. Specifically, AsA‐fed leaves had greater abundance of antioxidants (AsA, glutathione, alpha‐ & gamma‐tocopherol) and compatible solutes (proline, galactinol, and myo‐inositol). AsA‐fed leaves also had higher activity of antioxidant enzymes (superoxide dismutase, ascorbate peroxidase, and catalase). These changes, together, may improve FT via alleviating freeze‐induced oxidative stress as well as protecting membranes from freeze desiccation. Additionally, improved FT by AsA‐feeding may potentially include enhanced cell wall/lignin augmentation and bolstered secondary metabolism as indicated by diminished level of phenylalanine and increased abundance of branched amino acids, respectively.
Rapid inactivation of airborne porcine reproductive and respiratory syndrome virus using an atmospheric pressure air plasma
Authors: Nayak Gaurav , Andrews Austin J. , Marabella Ian , Aboubakr Hamada A. , Goyal Sagar M. , Olson Bernard A. , Torremorell Montserrat , Bruggeman Peter J. 
Published: February 2020

AbstractThe transmission of airborne diseases in animals poses great risks to animal safety with potential significant economic losses. In this study, we report on the use of a dielectric barrier discharge (DBD) for in‐flight inactivation of an airborne aerosolized porcine reproductive and respiratory syndrome virus. The infectivity of the sampled virus downstream compared to upstream of the DBD reactor as determined by the TCID50 method showed a ∼3.5 log10 reduction in the virus titer. Independent testing of the viral genome by the reverse‐transcription quantitative real‐time polymerase chain reaction method confirmed the inactivation with minimal filtering effects. Both short‐lived species such as and and peroxynitrous acid (ONOOH) chemistry at low pH in the virus‐laden droplets are suggested to be responsible for the observed inactivation.
Krasovskii and Razumikhin criteria on input‐to‐state stability of discrete‐time time‐varying switched delayed systems
Authors: Peng Shiguo , Deng Feiqi , Xiao Mingqing , Wang Yonghua 
Published: February 2020

SummaryIn this article, we are concerned with the problem on input‐to‐state stability (ISS) for discrete‐time time‐varying switched delayed systems. Some Krasovskii and Razumikhin ISS criteria are provided by using the notions of uniformly asymptotically stable (UAS) function and mode‐dependent average dwell time (MDADT). With the help of the concept of UAS function, the advantage of our results in this article is that the coefficients of the first‐order difference inequalities for the mode‐dependent Krasovskii functionals and mode‐dependent Razumikhin functions are allowed to be time‐varying, mode‐dependent, and can even take both positive and negative values, and the whole switched system can be allowed to have both ISS subsystems and non‐ISS subsystems. With the aid of the notion of MDADT, each subsystem can have its own average dwell time. As an application, we also provide an ISS criterion for discrete‐time time‐varying switched delayed Hopfield neural networks with disturbance inputs. Numerical simulations verify the effectiveness of the established criteria.
Effect of land use/cover changes on runoff in the Min River watershed
Authors: Ma Kai , Huang Xiaorong , Liang Chuan , Zhao Hongbin , Zhou Xingyu , Wei Xiaoyue 
Published: February 2020

AbstractQuantifying and interpreting the impacts that land use/cover change (LUCC) have on hydrology at basin scales are of great significance for the sustainable development of watershed ecosystems, water resources, and land management. The Soil and Water Assessment Tool was used to establish the regional model. The Min River watershed was divided into 236 sub‐basins, and simulations showed the spatial distribution of runoff in each sub‐basin with GIS‐based image displays. We set five scenarios to investigate the negative hydrological effects characterized by reductions in the water yield. From 1995 to 2004, the effect of simulated mean annual runoff caused by LUCC was −12.61 m3/s and the climate variability caused −67.61 m3/s. From 2005 to 2014, the hydrological effect caused by LUCC was −2.38 m3/s and the climate variability caused −58.53 m3/s. The elevation, Shannon's diversity index, largest patch index, and interspersion and juxtaposition index were all characterized by strong relationships with the sub‐basin outlet flows (adjusted R2 = 0.572) using multivariate stepwise regression analysis. Redundancy analysis further proved that the reduction in grassland has led to a decrease in vegetation dominance while large increase in cultivated and residential lands has led to a higher degree of landscape richness and fragmentation, which has caused the reduced water yield. The restoration of grassland vegetation, as well as urban and agricultural water usage should be the primary focus of flow recovery.
Target‐oriented habitat and wildlife management: estimating forage quantity and quality of semi‐natural grasslands with Sentinel‐1 and Sentinel‐2 data
Authors: Raab Christoph , Riesch Friederike , Tonn Bettina , Barrett Brian , Meißner Marcus , Balkenhol Niko , Isselstein Johannes 
Published: February 2020

AbstractSemi‐natural grasslands represent ecosystems with high biodiversity. Their conservation depends on the removal of biomass, for example, through grazing by livestock or wildlife. For this, spatially explicit information about grassland forage quantity and quality is a prerequisite for efficient management. The recent advancements of the Sentinel satellite mission offer new possibilities to support the conservation of semi‐natural grasslands. In this study, the combined use of radar (Sentinel‐1) and multispectral (Sentinel‐2) data to predict forage quantity and quality indicators of semi‐natural grassland in Germany was investigated. Field data for organic acid detergent fibre concentration (oADF), crude protein concentration (CP), compressed sward height (CSH) and standing biomass dry weight (DM) collected between 2015 and 2017 were related to remote sensing data using the random forest regression algorithm. In total, 102 optical‐ and radar‐based predictor variables were used to derive an optimized dataset, maximizing the predictive power of the respective model. High R2 values were obtained for the grassland quality indicators oADF (R2 = 0.79, RMSE = 2.29%) and CP (R2 = 0.72, RMSE = 1.70%) using 15 and 8 predictor variables respectively. Lower R2 values were achieved for the quantity indicators CSH (R2 = 0.60, RMSE = 2.77 cm) and DM (R2 = 0.45, RMSE = 90.84 g/m²). A permutation‐based variable importance measure indicated a strong contribution of simple ratio‐based optical indices to the model performance. In particular, the ratios between the narrow near‐infrared and red‐edge region were among the most important variables. The model performance for oADF, CP and CSH was only marginally increased by adding Sentinel‐1 data. For DM, no positive effect on the model performance was observed by combining Sentinel‐1 and Sentinel‐2 data. Thus, optical Sentinel‐2 data might be sufficient to accurately predict forage quality, and to some extent also quantity indicators of semi‐natural grassland.
Free‐Standing NiO Nanosheets as Non‐Enzymatic Electrochemical Sensors
Authors: Qin Yanan , Chen Fei , Halder Arnab , Zhang Minwei 
Published: February 2020

AbstractA simple, rapid and sensitive electrochemical sensor for determination of urea has been developed based on two‐dimensional (2D) Free‐standing NiO nanosheet. High quality, ultrathin two‐dimensional NiO nano‐sheets were synthesized by using graphene oxide paper as sacrificial template. Various techniques such as x‐ray diffraction (XRD), x‐ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM) and transmission electron microscopy (TEM) were used to characterize the morphology of the nanostructure. According to TEM image, the average size of the as‐synthesized NiO nanosheets is around 50 nm and with 5–20 nm pores. Electrochemical studies indicate that the 2D NiO papers exhibit excellent stability and high electrocatalytic activity for the oxidation of urea in an alkaline medium, even without any conductive supporting agent, and low oxidation potential (vs SCE), high sensitivity (3.4 A/M cm2) and a low detection limit (2 μM) as a non‐enzymatic sensor for urea.
Stability indicating LC method for estimation of Valbenazine and its degradation kinetic study
Authors: Parmar Payal J. , Patel Vandana B. , Shah Dimal A. 
Published: February 2020

AbstractStability indicating analytical method helps to identify the instrinsic stability of molecule and likely degradation pathway. Present study involves development of a liquid chromatography method for Valbenazine which can be used in the analysis of forced degraded samples along with its degradation kinetic study. The liquid chromatography method was developed using Column (Shimadzu ODS Shim‐pack Solar (250* 4.6 mm, 5 µm)) as stationary phase and acetonitrile/water (90:10) was used as mobile phase. Flow rate was maintained at 1 mL/min and detection was performed using diode array detector at 210 nm. The retention time of Valbenazine Tosylate was observed to be 7.2 min. The linear regression analysis data for the calibration plots showed a good linear relationship for Valbenazine Tosylate over a concentration range of 1–20 µg/mL. The proposed method was validated with respect to linearity, accuracy, precision and robustness. To find out the possible degradation pathway, forced degradation studies were performed. The degraded product peaks were well resolved from the pure drug peak with significant difference in their retention time. To determine the order of reaction for base degradation, kinetic studies were performed. The drug was found to follow first order kinetic for base degradation condition. The developed method can be used for analysis of stability samples and routing quality control evaluation of Valbenazine Tosylate in bulk.
The role of home governments in entry bargaining of multinationals: China's investment in Central Asia's natural resource sector
Authors: Orazgaliyev Serik 
Published: February 2020

AbstractOver the last two decades, China's participation in Central Asia's energy sector has increased dramatically. This article explores the case study of China's outward foreign direct investment (OFDI) in Central Asia's natural resource sector through the framework of bargaining model. Although the scholarly literature studied extensively FDI determinants and support of the home government on MNE activities abroad, there is little evidence‐based research on the effect of governmental negotiations on OFDI. The existing research on China's OFDI in natural resource sector highlighted the country's complex approach to energy deals, which was facilitated by investment in infrastructure projects and provision of loans. As this study confirmed, support with loans and investment in the development of export pipeline infrastructure was crucial in securing energy deals for Chinese multinationals (CMNEs). More specifically, this article makes an important contribution toward the understanding of China's investment in developing markets with high levels of political risk such as Central Asian region. The presented evidence suggests that there is a positive correlation between home government support and successful entry of CMNEs to natural resource sectors in emerging markets.