bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Merchant of Venice and the Paschal Moon
Authors: Usher Peter D. 
Published: May 2020

Abstract

The Merchant of Venice contains a puzzling passage by Lancelot Gobbo that refers to Ash Wednesday and Easter Monday, two dates in the Christian religious calendar. The passage is nonsensical, yet it is a commonplace that the utterances of Shakespeare’s clowns are often noteworthy. This paper notes that Lancelot refers to an unusual four-fold coincidence of Passover with Easter Monday, the former on the correct Gregorian calendar, the latter on the outdated Julian calendar. The interpretation is tested and leads to the determination of the dramatic time of the play which with other evidence from the script suggests that the paschal moon of 14 Nisan 5357 (April 2, 1597) is a crux of the play. The resulting timeline is consistent with events in the script and leads to a new interpretation for Old Gobbo’s dish of doves. The timeline leads also to a solution for a question on equity and the law.
Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)-directed treatment of peritoneal metastasis in end-stage colo-rectal cancer patients
Authors: Ellebæk Signe Bremholm , Graversen Martin , Detlefsen Sönke , Lundell Lars , Fristrup Claus W. , Pfeiffer Per , Mortensen Michael B. 
Published: May 2020

AbstractBackgroundPressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) represents a novel approach to intraperitoneal chemotherapy. Hereby results, obtained with PIPAC in patients with advanced peritoneal metastasis (PM) from colorectal cancer (CRC), are presented.MethodsData from CRC patients (n = 24) included in the prospective PIPAC-OPC1 and PIPAC-OPC2 trials are reported. Oxaliplatin 92 mg/m2 was administered at 4-6-week intervals. A CE certified nebulizer was used to aerosolize the chemotherapeutics. Outcome criteria were objective tumor response, survival and adverse events.ResultsRetrospective analysis of 74 PIPAC procedures carried out in 24 consecutive patients with PM from CRC included from October 2015 to February 2019. Five patients had still the primary tumor in situ, and 22 patients had received palliative systemic chemotherapy. Nineteen patients completed more than two PIPAC procedures, and objective tumor response according to the histological Peritoneal Regression Grading Score (PRGS) was observed in 67% of the patients, while 21% had stable disease. Four patients (21%) had complete response (mean PRGS = 1 and negative cytology). We recorded a median survival of 37.6 (range 7.3–48.9) months from the time of PM diagnosis, whereas it was 20.5 (range 0.13–34.7) months following the first PIPAC session. Minor postoperative complications were noted, and few were considered causally related to the PIPAC treatment. However, two cases of severe postoperative complications were recorded (urosepsis and iatrogenic bowel perforation).ConclusionsPIPAC with low-dose oxaliplatin can induce objective tumor regression in selected patients with advanced PM from colorectal cancer.
1H-NMR spectroscopy metabonomics of reactive, ovarian carcinoma and hepatocellular carcinoma ascites
Authors: Zennaro Lucio , Nicolè Lorenzo , Vanzani Paola , Cappello Filippo , Fassina Ambrogio 
Published: May 2020

AbstractBackgroundMetabolomic profiling of human malignant effusion remain a field poorly investigated. Proton nuclear magnetic resonance (1H-NMR) spectroscopy is a rapid relatively low cost technique, and effusion is an optimal biospecimen suitable for metabonomic investigations. With this study we addressed metabolomic profiling of malignant ascitic effusion (mAE) from patients with high grade serous ovarian carcinoma (HGSOC), Hepatocellular carcinoma (HCC), and benign AEs (bAEs) from patients with reactive peritonitis.MethodsMetabolic profiling with 1H-NMR was performed on 72 AEs (31 HGSOC, 16 HCC and 25 bAE) prospectively collected in our cytology service. Histological confirmation was requested for all malignant case. Multivariate analysis comprising PCA and PLS-DA was applied to discover metabolites suitable to differentiate effusions among the investigated groups.Results1H-NMR metabonomic analysis showed clearly different spectra for malignant and benign AEs, as well as for HGSOC vs. HCC effusion. When compared with HCC effusions, the HGSOC effusion were enriched, among all, in alanine, lipids, N-acetyl groups and phenylalanine and depleted in glutamine.ConclusionsSubject to validation in further larger studies, 1H-NMR metabonomics could be an effective and reliable ancillary tool for AE investigations and diagnosis particularly in acellular effusions.
Domino and one-pot syntheses of biologically active compounds using diphenylprolinol silyl ether
Authors: Hayashi Yujiro 
Published: May 2020

AbstractThe successful application of diphenylprolinol silyl ether, which is one of the widely used organocatalysts, to the synthesis of natural products and drugs, is described mostly focusing on the author’s results. The molecules that are explained in this paper are baclofen, telcagepant, oseltamivir, ABT-341, prostaglandins, estradiol, horsfiline and coerulescine.
Inorganic acids – technology background and future perspectives
Authors: Ciesielczyk Filip 
Published: May 2020

AbstractThe presented chapter deals with technological aspects concerning industrial production of major inorganic chemicals such as sulfuric, nitric and phosphorous acids. The idea was to highlight the main assumptions related to their fabrication as well as to point out novel aspects and perspectives concerning their industry. The main attention will be paid to raw materials and their transformation in order to obtain indirect precursors of inorganic acids – acid anhydrides. Characteristics of the individual stages of synthesis, with a special regard to the process conditions will be also of key importance. The environmental impact of this particular technology will be raised and discussed. Finally, the review over recently published scientific papers, concerning innovative solutions in inorganic acids production, will be performed.
A computer-based approach for developing linamarase inhibitory agents
Authors: Paul Lucas , Mudogo Celestin N. , Mtei Kelvin M. , Machunda Revocatus L. , Ntie-Kang Fidele 
Published: May 2020

AbstractCassava is a strategic crop, especially for developing countries. However, the presence of cyanogenic compounds in cassava products limits the proper nutrients utilization. Due to the poor availability of structure discovery and elucidation in the Protein Data Bank is limiting the full understanding of the enzyme, how to inhibit it and applications in different fields. There is a need to solve the three-dimensional structure (3-D) of linamarase from cassava. The structural elucidation will allow the development of a competitive inhibitor and various industrial applications of the enzyme. The goal of this review is to summarize and present the available 3-D modeling structure of linamarase enzyme using different computational strategies. This approach could help in determining the structure of linamarase and later guide the structure elucidationin silicoand experimentally.
Fluorescence and fluorescent dyes
Authors: Langhals Heinz 
Published: May 2020

Abstract
The handling and control of light is becoming more and more attractive in science and technology such as data processing and requires functional chromophores. As a consequence, fluorescent materials are of special importance because they allow the processing of light energy. Thus, basics of fluorescence are reported as prerequisites for planning complex functional structures. Various fluorescent systems are presented beginning with historic observations followed by a detailed discussion of light absorption and emission indicating fluorescent chromophores as molecular resonators; molecular dynamics and intermolecular interactions are leading to complex functional materials.
GERPAC Consensus Conference – Guidance on the Assignment of Microbiological Shelf-life for Hospital Pharmacy Aseptic Preparations
Authors: Crauste-Manciet Sylvie , Krämer Irene , Lagarce Frederic , Sautou Valerie , Beaney Alison , Smith Julian , Fenton-May V’Iain , Hecq Jean-Daniel , Sadeghipour Farshid , Brun Paul Le 
Published: May 2020

AbstractAll dosage forms prepared in hospital pharmacies should be labelled with an appropriate shelf-life. This shelf-life should be validated taking chemical, physical and microbiological data into consideration. This guidance focuses on parenteral aseptically prepared products, as they are high-risk preparations. The risk is exacerbated by a requirement for longer shelf lives for reasons of economy and efficiency. The scope of this guidance includes individual patient preparations, preparations prepared in series (same type of preparation being repeatedly prepared) and batch preparations prepared from the same initial bulk admixture.
A review on fly ash from coal-fired power plants: chemical composition, regulations, and health evidence
Authors: Zierold Kristina M. , Odoh Chisom 
Published: May 2020

AbstractThroughout the world, coal is responsible for generating approximately 38% of power. Coal ash, a waste product, generated from the combustion of coal, consists of fly ash, bottom ash, boiler slag, and flue gas desulfurization material. Fly ash, which is the main component of coal ash, is composed of spherical particulate matter with diameters that range from 0.1 μm to >100 μm. Fly ash is predominately composed of silica, aluminum, iron, calcium, and oxygen, but the particles may also contain heavy metals such as arsenic and lead at trace levels. Most nations throughout the world do not consider fly ash a hazardous waste and therefore regulations on its disposal and storage are lacking. Fly ash that is not beneficially reused in products such as concrete is stored in landfills and surface impoundments. Fugitive dust emissions and leaching of metals into groundwater from landfills and surface impoundments may put people at risk for exposure. There are limited epidemiological studies regarding the health effects of fly ash exposure. In this article, the authors provide an overview of fly ash, its chemical composition, the regulations from nations generating the greatest amount of fly ash, and epidemiological evidence regarding the health impacts associated with exposure to fly ash.
VICTORIA transform, RESPECT and REFORM methods for the proof of the G-Elliptic Law under G-Lindeberg condition and twice stochastic condition for the variances and covariances of the entries of some random matrices
Authors: Girko Vyacheslav L. 
Published: May 2020

AbstractThe G-Elliptic law under the G-Lindeberg condition for the independent pairs of the
entries of a random matrix is proven.
Zur Konstruktion von Spiritualität im Gesundheitswesen
Authors: Frick Eckhard , Bettenbrock Benjamin , Roser Traugott , Deffner Teresa 
Published: May 2020

ZusammenfassungWissenschaftliche Communities bemühen sich um Konsensusdefinitionen von Basiskonzepten, die der empirischen Forschung zu Grunde liegen. In der Forschung über Spiritualität und Spiritual Care können etic-Daten (erhoben durch operationalisierte Methoden) und idiosynkratische, stark subjektive emic-Daten unterschieden werden. Interessanterweise können auch empirische Forscher und Spiritualitäts-Experten ihre persönliche emic-Perspektive ausdrücken, die sehr verschieden von der Perspektive ihrer Kollegen sein kann. Diese Studie verwendet die Repertory Grid Technik (RGT), eine empirische Methode zur Erfassung idiosynkratischer psychologischer Charakteristika, um die persönlichen Konstrukte von „Spiritualität“ und „Spiritual Care“ bei Experten in diesen Forschungs- und Praxisfeldern zu untersuchen.
Comparing various influences on adhesive contact with friction
Authors: Vodička Roman 
Published: May 2020

Abstract
A general computational model covering many types of frictional contact interfaces between visco-elastic bodies is considered for some cases physically relevant in numerical analysis of contact in civil engineering structures. The relations between mechanical quantities and internal parameters of the model are illustrated in a couple of simplified examples including cohesive contact combined with Coulomb friction and/or interface plasticity. The computations are implemented a semi-implicit time discretisation, quadratic programming algorithms, and the boundary-element method.
Non-canonical inverse in Circassian languages
Authors: Arkadiev Peter 
Published: May 2020

AbstractThis paper discusses a typologically peculiar inverse-like construction found in the polysynthetic ergative Circassian languages of the Northwest-Caucasian family. These languages possess a cislocative verbal prefix, which, in addition to marking the spatial meaning of speaker-orientation, systematically occurs in polyvalent verbs when the object outranks the subject on the person hierarchy. The inverse-like use of the cislocative in Circassian differs from the “canonical” direct-inverse system in that, first, it is fully redundant since the person-role linking is achieved by means of the person markers themselves and, second, it does not occur in the basic transitive construction, featuring instead in configurations involving an indirect object both in ditransitive and bivalent intransitive verbs. It is argued that the typologically outstanding properties of the Circassian inverse-like marking can be naturally explained by its diachronic origin.
Counsellors’ interactional practices for facilitating group members’ affiliative talk about personal experiences in group counselling
Authors: Weiste Elina , Tiitinen Sanni , Vehviläinen Sanna , Ruusuvuori Johanna , Laitinen Jaana 
Published: May 2020

AbstractAffiliative talk about personal experiences, that is, talk that supports the person’s affective stance towards the experience, is important in all types of counselling. Often, however, this is not the only or even the main goal of the counselling. We investigate what interactional practices counsellors use to facilitate group members’ affiliative talk about their personal experiences in a problem focused, health promotion group counselling. The findings are based on a conversation analysis of 23 video-recorded group counselling sessions. We present four interactional practices by counsellors for facilitating participants’ talk about their personal experiences in relation to other group members’ experiences. We demonstrate that each interactional practice sets up a different space for telling about one’s experiences in an affiliative way. Loosely designed questions about group members’ thoughts at the end of an assignment seem to engender stretches of affiliative talk about personal experiences very efficiently. We suggest that even if the counselling is focused on solving group members’ problems, it should include time for loosely structured discussions among group members to support affiliative talk.
Metadiscourse and the management of relationships during online conflict among academics
Authors: Shrikant Natasha 
Published: May 2020

AbstractThis study analyzes how members of an online academic committee use metadiscourse to manage communicative norms and relationships during conflict. The data analyzed include 67 listserv posts among academics developing a solution to a conference scheduling conflict. Discourse analysis highlights how tensions between the group’s leader and the group members escalate throughout the interactions. The conflict began when the participants opposed the group leader through positively evaluating the content of their leader’s email, yet re-formulating their leader’s proposed communication process. When the group leader ignored members, the members escalated opposition through negatively formulating the leader’s actions, taking overt negative affective stances, asking the leader to change his decision, and withdrawing from the committee without resolving conflict. Analysis of the group’s metadiscourse illustrates that the group members withdrew not because they disagreed with the leader’s solution, but because they oriented to their leader as repeatedly violating academia-specific communication and relational preferences: the group leader attempted to conduct a top-down, closed conversation, while the group members preferred an open discussion among equals. These findings highlight the need to attend to community-specific communication and relational preferences, particularly when online interactions are the primary form of relational maintenance.
Effect of transportation and freeze-thaw procedure on hemostatic tests
Authors: Öngen İpek Belkız , Sitar Mustafa Erinç 
Published: May 2020

Abstract

Objective
Coagulation tests are sensitive to pre-analytical variables. The aim of our study is to identify the effect of transportation and freeze-thaw status on for Factor VIII, Factor IX, Anti-thrombin III, Protein S, Protein C, Prothrombin time (PT) and Activated partial thromboplastin time (aPTT).

Materials and methods
The study was performed on 102 plasma samples obtained from 34 healthy volunteers. The samples were divided into three groups. Group A was analyzed whereas group B, C were frozen at −20°C. After 24 h, group B and C were transported for 2 h. Following the transfer, group B was analyzed and C was frozen at −20°C. After 24 h, group C was analyzed. Analyses of samples were performed in Thrombolyzer-XRM for PT, aPTT, Factor VIII, Factor IX, Anti-thrombin III, Protein C and Protein S.

Results
There were significant variations for PT, aPTT, Protein S, Factor VIII and Factor IX for group A&B and A&C comparisons in different stability criteria approaches. In significant change limit and percentage change calculations Protein S, Factor VIII and IX showed significant differences. For acceptable change limit approach, aPTT and Factor IX showed significant changes.

Conclusion
Laboratories should take precautions for transportation and freeze-thaw cycles to prevent inaccurate results.
Atypical cells in sysmex UN automated urine particle analyzer: a case report and pitfalls for future studies
Authors: Aydin Ozgur , Yapıcı Onur , Copuroglu Ruksan 
Published: May 2020

Abstract

Objectives
Sysmex UN series fully automated urine analyzer reports a series of research parameters besides routine parameters including the “atypical cells” parameter. An automated instrument in clinical use capable of detecting neoplastic cells of the urinary tract will have paramount significance.

Case presentation
A 73 years old male patient with a recurrent high grade urothelial carcinoma admitted to our urology outpatient clinic due to hematuria.
Urinalysis showed +3 hemoglobin, +3 leukocyte esterase, 200/HPF red blood cells, 300/HPF white blood cells. The instrument also reported atypical cells (7.6/µL or 1.3/HPF) under the heading of “research parameters.” Presence of atypical cells was confirmed by the manual microscopy. The patient has undergone transurethral resection of papillary lesions and the pathology report confirmed a recurrence. On follow-up, atypical cells fell to 0.1/µL after 40 days.

Conclusions
This case report presents a patient with atypical cells in urine, detected by a fully automated urine analyzer. The atypical cells presented on the screen of the analyzer were confirmed by the manual microscopy. This presentation may influence future studies pertaining to the subject.
Study of Correctly Expanded Sonic Jet with Air Tabs
Authors: R Arun Prasad , S Thanigaiarasu , M Sembaruthi , E Rathakrishnan 
Published: May 2020

Abstract
The present numerical study is to understand the effect of air tabs located at the exit of a convergent nozzle on the spreading and mixing characteristics of correctly expanded sonic primary jet. Air tabs used in this study are two secondary jets issuing from constant diameter tubes located diametrically opposite at the periphery of the primary nozzle exit, normal to the primary jet. Two air tabs of Mach numbers 1.0 to 1.4, in steps of 0.1 are considered in this study. The mixing modification caused by air tabs are analysed by considering the mixing of uncontrolled (free) primary jet as a reference. Substantial enhancement in jet mixing is achieved with Mach 1.4 air tabs, which results in 80 % potential core length reduction. The total pressure profiles taken on the plane (YZ) normal to the primary jet axis, at various locations along the primary jet centreline revealed the modification of the jet cross sectional shape by air tabs. The stream-wise vortices and bifurcation of the primary jet caused by air tabs are found to be the mechanism behind the enhanced jet mixing.
Global Justice: A Utopia and Concern of Humanitarianism
Authors: Qun Gong 
Published: May 2020

Abstract
Global justice or the lack thereof has internal connections with global poverty. Global justice is an ideal pursuit of cosmopolitanism, which regards basic human needs as its rightful object. The right to life, from the point of view of global justice, is the most fundamental in the list of Human Rights. International anarchy and the current international economic order, however, cast a utopian shadow on the realization of this right when we consider the de facto institutions and the ostensible goal of impartial love for everyone. Humanitarian aid is another approach to the problem of contemporary global poverty. Its difficulty lies first in people’s different conceptions of obligation and donation. They consider the former as duty while the latter is seen to lie beyond the call of duty. Second, in terms of a correlation between right and duty, since everyone has the right to life, the duty falls accordingly upon organizations or individuals. Meanwhile, donation as duty is not perfect obligation, thus is not compulsory either. Finally, international humanitarian aid is constrained by nationalism and partial love. Hence, in the light of either government or individual, the humanitarian aid approach is beset with challenges.
Global justice has gained academic importance worldwide since John Rawls’ later works. By contrast to domestic justice, it is a theory of justice that proposes to include all human beings. Global justice stands for a kind of utopian justice in regard to both the institutional path and the humanitarian aid approach. I shall examine the theory of global justice under these two aspects.
The Interdependence of Domestic and Global Justice
Authors: Beck Valentin 
Published: May 2020

AbstractThis article focuses on the challenge of determining the relative weight of domestic and global justice demands. This problem concerns a variety of views that differ on the metric, function, scope, grounds and fundamental interpretation of justice norms. I argue that domestic and global economic justice are irreducibly interdependent. In order to address their exact relation, I discuss and compare three theoretical models: (i) the bottom-up-approach, which prioritizes domestic justice; (ii) the top-down-approach, which prioritizes global justice; and (iii) the horizontal framework, according to which both domestic and global principles pose equally stringent demands that are to be implemented horizontally, without attributing a simple priority to one over the other. I argue that the third model represents the best overall framework, although more complex normative criteria need to be elaborated on the basis of this approach, affecting issues such as justice in climate change mitigation and adaption, development cooperation, trade, finance, taxation and immigration.