bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aberrant β-catenin Activity in Hepatoid Adenocarcinoma of the Stomach
Authors: Wang Nan , Kong Rui , Han Wei , Lu Jie 
Published: May 2020

Background:
Hepatoid adenocarcinoma of the stomach (HAS) has been
recognized as a rare primary gastric tumor characterized by hepatocellular carcinomalike
histology. HAS often causes diagnostic confusion with conventional gastric
adenocarcinoma (CGA) due to the difficulty to detect hepatoid differentiation solely
based on findings from hematoxylin and eosin (H&E) staining. β-catenin is highly
expressed in hepatocellular carcinoma (HCC), which is involved in the maintenance of
tumor initiating cells, drug resistance, tumor progression, and metastasis. Due to the
scarcity of confirmed cases of HAS, there are few studies on β-catenin.

Objectives:
14 patients diagnosed in our hospital were selected.

Methods:
The clinical characteristics of 14 patients were statistically studied, and
pathological specimens were analyzed by immunohistochemistry.

Results:
We detected statistically significant difference in the expression of β-catenin (P
= 0.000), glypican3 (P = 0.019), and hepar-1 (P = 0.007) between HAS cancer tissues
and normal tissues. Furthermore, a significant correlation was found between the
expression of β-catenin in HAS cancer tissue and normal tissue (Pearson correlation
coefficient: 0.686, P = 0.007). Meanwhile, a significant correlation was observed
between the expression of β-catenin and survival time (Spearman correlation
coefficient= - 0.482, P = 0.003). However, we found the expression of β-catenin did not
correlate with the tumor differentiation and size, age, gender, serum AFP levels,
microinvasion, and metastasis (P > 0.05).

Conclusion:
Our findings establish β-catenin as a useful marker that can distinguish
HAS from CGA and may improve the early diagnosis to guide the appropriate and timely
treatment of HAS patients.
Plant-Derived Butters as Lipid Nanocarriers: A Systematic and Prospective Review
Authors: Coelho Angélica G. , dos Santos Webysten R.P. , dos Santos Andressa A. , da Silva Maisa G. , Cunha Francisco V. Macedo , Mendes Anderson N. , Arcanjo Daniel D.R. 
Published: May 2020

Background:
Pharmaceutical nanotechnology represents an efficient alternative for the delivery
of pharmacologically active plant-derived compounds, considering their protective capacity, oral
bioavailability and drug vectorization capacity. In this context, butters obtained from plant seeds have
emerged as promising products for the development of pharmacologically active nanostructures. They
possess a complex lipid composition, allowing the formation of different emulsion systems with solid
cores, since this mixture of different triglycerides is solid at room temperature and body temperature.
Therefore, the systematic mapping around the technological development of nanostructures produced
from plant-derived butters is potentially valuable for researchers interested in novel alternative formulations
for pharmacological therapy, with potential industrial, economic, health and societal impacts.

Methods:
Systematic review was carried out by the search of scientific papers and patents deposited in
official databases concerning the development of nanostructured pharmaceutical products using plantderived
butters as starting material. The publications obtained were subjected to sorting and analysis
by applying the following inclusion/exclusion criteria.

Results:
The Solid Lipid Nanoparticle (SLN) was the type of nanostructure produced in all the analyzed
scientific papers, due to the physicochemical characteristics of the lipid constituents of plantderived
butters. In this sense, 54% of the articles have reported the use of Cocoa Butter for the production
of nanostructures; 28% for Shea Butter; 6% for Cupuacu Butter, 6% for Murumuru Butter and 6%
for Bacuri Butter.

Discussion:
In the technological prospection, only two patents exhibited SLN as an invention based on
cocoa butter and on shea butter, respectively. The production methods employed have included: phase
inversion temperature, microemulsion, hot high pressure homogenization, high shear homogenization
and ultrasonication.

Conclusion:
In light of this prospective review, the encouragement of novel studies in lipids-based
nanotechnology is evident, considering the small number of findings so far, in order to stimulate new
research involving plant-derived butters from easily cultivated fruits in tropical regions, then stimulating
the pharmaceutical development of new therapeutic alternatives using biocompatible and sustainable
raw materials.
Malaria, Collapsing Glomerulopathy, and Focal and Segmental Glomerulosclerosis
Authors: Amoura Ariane , Moktefi Anissa , Halfon Matthieu , Karras Alexandre , Rafat Cédric , Gibier Jean-Baptiste , Gleeson Patrick J. , Servais Aude , Argy Nicolas , Maillé Pascale , Belenfant Xavier , Gueutin Victor , Delpierre Alexia , Tricot Leila , El Karoui Khalil , Jourde-Chiche Noémie , Houze Sandrine , Sahali Dil , Audard Vincent 
Published: May 2020

Background and objectives
Malaria, a potentially life-threatening disease, is the most prevalent endemic infectious disease worldwide. In the modern era, the spectrum of glomerular involvement observed in patients after malarial infections remains poorly described.

Design, setting, participants, & measurements
We therefore performed a retrospective multicenter study to assess the clinical, biologic, pathologic, and therapeutic characteristics of patients with glomerular disease demonstrated by kidney biopsy in France within 3 months of an acute malaria episode.

Results
We identified 23 patients (12 men), all but 1 of African ancestry and including 10 patients with concomitant HIV infection. All of the imported cases were in French citizens living in France who had recently traveled back to France from an endemic area and developed malaria after their return to France. Eleven patients had to be admitted to an intensive care unit at presentation. Plasmodium falciparum was detected in 22 patients, and Plasmodium malariae was detected in 1 patient. Kidney biopsy was performed after the successful treatment of malaria, a mean of 24 days after initial presentation. At this time, all patients displayed AKI, requiring KRT in 12 patients. Nephrotic syndrome was diagnosed in 17 patients. Pathologic findings included FSGS in 21 patients and minimal change nephrotic syndrome in 2 patients. Among patients with FSGS, 18 had collapsing glomerulopathy (including 9 patients with HIV-associated nephropathy). In four patients, immunohistochemistry with an antibody targeting P. falciparum histidine-rich protein-2 demonstrated the presence of the malaria antigen in tubular cells but not in podocytes or parietal epithelial cells. An analysis of the apoL1 risk genotype showed that high-risk variants were present in all seven patients tested. After a mean follow-up of 23 months, eight patients required KRT (kidney transplantation in two patients), and mean eGFR for the other patients was 51 ml/min per 1.73 m2.

Conclusions
In patients of African ancestry, imported Plasmodium infection may be a new causal factor for secondary FSGS, particularly for collapsing glomerulopathy variants in an APOL1 high-risk variant background.
Clinical Features of Maintenance Hemodialysis Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China
Authors: Wu Jun , Li Jushuang , Zhu Geli , Zhang Yanxia , Bi Zhimin , Yu Yean , Huang Bo , Fu Shouzhi , Tan Yiqing , Sun Jianbin , Li Xiangyou 
Published: May 2020

Background and objectives
Previous reports on the outbreak of coronavirus disease 2019 were on the basis of data from the general population. Our study aimed to investigate the clinical features of patients on maintenance hemodialysis.

Design, setting, participants, & measurements
In this retrospective, single-center study, we included 49 hospitalized patients on maintenance hemodialysis and 52 hospitalized patients without kidney failure (controls) with confirmed coronavirus disease 2019 at Tongren Hospital of Wuhan University from January 30, 2020 to March 10, 2020. Demographic, clinical, laboratory, and radiologic characteristics and treatment and outcomes data were analyzed. The final date of follow-up was March 19, 2020.

Results
The median age of 101 patients was 62 years (interquartile range, 49–72). All patients were local residents of Wuhan. In terms of common symptoms, there were differences between patients on hemodialysis and controls (fatigue [59% versus 83%], dry cough [49% versus 71%], and fever [47% versus 90%]). Lymphocyte counts were decreased (0.8×109/L [patients on hemodialysis] versus 0.9×109/L [controls], P=0.02). Comparing patients on hemodialysis with controls, creatine kinase–muscle and brain type, myoglobin, hypersensitive troponin I, B-type natriuretic peptide, and procalcitonin were increased, and the percentage of abnormalities in bilateral lung was higher in computed tomographic scan (82% versus 69%, P=0.15) and unilateral lung was lower (10% versus 27%, P=0.03). Common complications including shock, acute respiratory distress syndrome, arrhythmia, and acute cardiac injury in patients on hemodialysis were significantly higher. Compared with controls, more patients on hemodialysis received noninvasive ventilation (25% versus 6%, P=0.008). As of March 19, 2020, three patients on hemodialysis (6%) were transferred to the intensive care unit and received invasive ventilation. Seven patients on hemodialysis (14%) had died.

Conclusions
The main symptoms of coronavirus disease 2019 pneumonia, including fever and cough, were less common in patients on hemodialysis. Patients on hemodialysis with coronavirus disease 2019 were at higher risk of death.
Emerging Psychedelic-Assisted Therapies: Implications for Nursing Practice
Authors: Denis-Lalonde Dominique , Estefan Andrew 
Published: May 2020

BackgroundPsychedelic-assisted therapy research is demonstrating unprecedented rates of success in treating mental illness, addictions, and end-of-life distress. This psychedelic renaissance is a turning point in how complex human conditions can be treated and has implications for nursing knowledge, advocacy, and practice internationally.ObjectiveThis article aims to explore the current state of knowledge in the field of psychedelic-assisted therapy and the practice implications for nurses.MethodsA scoping review of the literature was undertaken with a focus on mental health, addictions, and palliative care indications. Commentaries, syntheses, and reviews from the last 20 years were included, as well as all relevant primary study results. We then explored what is known about the nurse's past and present role in this field.ResultsThe nurse's role in psychedelic-assisted therapy and research has been hitherto mostly invisible and thus remains under-explored and undefined. The profession is ideally positioned, however, to contribute to the future of this promising field.ConclusionAs advocates for safe, ethical, and interdisciplinary practice, nurses can lead the development of psychedelic-assisted therapy practice, ethics, research, advocacy, policy, and education. This article provides guidance and support for prescient nursing leadership in these areas.
Self-Efficacy and Diabetes Self-Management in Middle-Aged and Older Adults in the United States: A Systematic Review
Authors: Qin Weidi , Blanchette Julia E. , Yoon Miyoung 
Published: May 2020

OBJECTIVE | This study aimed to systematically review the existing literature on the relationship between self-efficacy and diabetes self-management in middle-aged and older adults in the United States and to determine whether the relationship applies across race and ethnicity.
METHODS | Study selection followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method. Studies published between 1990 to 2018 that investigated self-efficacy and diabetes self-management in middle-aged and older adults were searched using eight search engines: PsycINFO, CINAHL, SocIndex, AgeLine, MedLine, Social Science Citation Index, Cochrane Library, and Academic Search Complete. Only quantitative studies were included.
RESULTS | Eleven studies met the inclusion criteria. Ten studies found significant association between self-efficacy and at least one self-management behavior, which included exercise, healthy diet, adherence to medication, blood glucose testing, and foot care. Findings were mixed regarding the role of self-efficacy in exercise and medication adherence. Higher self-efficacy in Mexican Americans predicted better self-management behaviors, whereas no relationship between self-efficacy and diabetes self-management was found in a sample of Black and White participants. The methodological quality of the studies was assessed. In general, the included studies demonstrated moderate methodological quality. Their limitations included inconsistency in the self-efficacy measures, a lack of longitudinal studies, and confounding bias.
CONCLUSION | Self-efficacy has significant effects on self-management in middle-aged and older adults, but the effects may differ by race. Efforts to improve self-efficacy and deliver culturally appropriate services could potentially promote self-management behaviors in middle-aged and older adults with diabetes.
Implementation of Prisoners' Self-Guidance Development at Penitentiary Institutions to Eradicate Negative Stigma
Authors: Febrianto Dewa Dermawan 
Published: May 2020

In Law 12 of 1995 concerning Correctional, it is explained that the convict is someone who has obtained permanent legal force from the court for violating the law he commited and placed in a correctional institution. In undergoing their criminal term in correctional institution they receive guidance in order to realize their mistakes, improve themselves, and no longer to repeat their criminal acts, so that they can be readmitted into the community. In the process of their return to the community, many of them were struggled to adapt again, because of negative stigmatization of the community. The impact is they will find hard to get a decent job, will be exclude from the community, and even worse they will did their crime again. In correctional institution there is a term for recidivist or a term for those ex-convict who have been released but go back again into correctional institution for repeating their crime. In this case many opinions from outside assume if the coaching process was given did not go well or failed. So in the study will discuss how to disperse the negative stigma of ex-convicts through the implementation results of the guidance that has been given into the community.
Fire disaster preparedness of public buildings in Ibadan metropolis, Nigeria
Authors: Adeleye Oluwaseyi Igbekele 
Published: May 2020

Fire outbreaks have risen to a worldwide attention in recent years as both an environmental and economic issue. Despite the fact that nothing could be sustainably done to completely stop the occurrence of fire disaster, something could be done to mitigate the spread. This study therefore assessed fire preparedness and mitigation provisions in the events of fire disaster in public buildings in Ibadan Metropolis, Nigeria. Disaster Preparedness provided the conceptual framework for this study. Cross-sectional survey was adopted in this study. Forty three (43) public buildings and one hundred and eight (108) building users were conveniently selected and sampled. Data were gathered through direct observation and questionnaire administration in selected buildings. Findings showed that banks, social buildings and hospitals were the public buildings more committed to providing and maintaining fire safety equipment. The study also revealed that 51.9% of the occupants of the public buildings have poor knowledge in the operation of fire safety installations. The study concluded by recommending that existing fire safety provisions in building codes should be reviewed and implemented with defaulters punished according to the law. Additionally, public building occupants should be compelled to participate in regular training on fire safety, fire disaster first aid and evacuation procedure.
Improving the Health System with Performance Reporting – Real Gains or Unnecessary Work?
Authors: Day Gary E , South Linda 
Published: May 2020

Aim: This paper will discuss current approaches to performance reporting and whether there are real benefits to healthcare organisations or whether it is a time consuming activity that adds little to improving quality healthcare and organisational performance. Most importantly, this paper will argue that performance reporting will not prevent another major healthcare scandal, such as that seen at Bundaberg Hospital or NHS Mid Staffordshire Trust. The paper will also outline learnings for Australia from other health systems where performance reporting is part of management practice.
Approach: While performance reporting is largely designed to increase the efficiency and effectiveness of healthcare organisations, this paper will explore the approach from a practical managerial perspective.
Context: This paper explores performance reporting across a range of Australian healthcare organisational settings to highlight differing approaches to improving performance.
Main findings: Performance reporting can be an effective tool to improve organisational performance. For performance reporting to be successful, managers and clinicians need to work collaboratively to identify areas for performance improvement and useful measures to address these. Additionally, organisations must choose a meaningful suite of measurements that can help drive performance improvement. Real time performance reporting, such as through performance dashboards, provides managers with the opportunity to make timely, incremental improvements. Finally, performance reporting must be done in a way that does not detract from providing safe, quality patient care.
Conclusions: Performance reporting can be a useful management tool for healthcare organisations, however organisations must consider timeliness of performance reporting and select a number of measurements that have impact for their given facilities and avoid the wholesale analysis of data that has little opportunity to improve practice or performance.
Abbreviations: LHN – Local Health Network; NEAT – National Emergency Access Targets; NHPA – National Health Performance Authority.
Employability Skills in Health Services Management: perceptions of recent graduates
Authors: Messum Diana Glen , Wilkes Lesley Marie , Jackson Debra , Peters Kath 
Published: May 2020

Background: Employer skill requirements of graduates are monitored by Graduate Careers Australia, but health services management (HSM) specific employability skills (ES) perceived by graduates to be important on the job and their perceptions of skills they need to improve are not well reported. Academics need this feedback to improve course employment outcomes by helping current students identify and articulate appropriatecompetencies to potential employers. Also teaching of industry requirements can help improve job matching for employers.
Method: Recent graduates working in HSM in New South Wales, Australia were surveyed to rate ES for importance and rate their own skill levels on the same items. The gap between these two ratings was identified for 44 ES. Results: ES important to recent graduates in rank order were: verbal communication skills, integrity and ethical conduct, time management, teamwork, priority setting, ability to work independently, organisational skills, written communication, being flexible and open minded and networking. Highest self-ratings were found for integrity and ethical conduct, ability to work independently, being flexible and open minded, tertiary qualifications, interpersonal skills, written communication skills, time management, life-long learning, priority setting and administration skills. Generally graduates rated their skills lower than their ratings of importance.
Conclusions: Recent graduates can provide valuable feedback to universities about ES required for HSM positions and identify their own skill gaps for development at work or through study. Generic skills rather than job-specific skills are what they rate as most important. Closer engagement of universities and employers is recommended especially through placements.
Abbreviations: ES – employability skills; GCA – Graduate Careers Australia; HEI – higher education institutions; HRM – human resource management; HSM – health services management; IPC – interpersonal and communication skills.
Using Linked Lung Cancer Registry and Hospital Data for Guiding Health Service Improvement
Authors: Roder David , You Hui , Baker Deborah , Walton Richard , McCaughan Brian , Sranda Sanchia , Currow David 
Published: May 2020

Objective: To use linked NSW Cancer Registry and hospital lung cancer (LC) data for raising discussion points on how to improve outcomes.
Design: Historical cohort – cases diagnosed in 2003-2007.
Setting: New South Wales, Australia
Outcome Measures: Relative odds (OR) of localised disease and resection of non-small cases (NSCLC) using multiple logistic regression. Comparisons of risk of NSCLC death using competing risk regression.
Findings: (1) Older patients have fewer resections of localised NSCLC [adjusted OR 95% CLs; 80+Vs <60 years; 0.20 (0.14, 0.28)]. Cases with co-morbidity have fewer resections [adjusted OR, 0.74 (0.61, 0.90)] and have more conservative resections. Question: Is there the best balance between resection and avoiding surgery to accommodate frailty and co-morbidity? (2) Compared with public patients, the health insured: have higher odds of localised LC [adjusted OR, 1.23 (1.12, 1.35] and resection for localised NSCLC [adjusted OR, 2.08 (1.70, 2.54)]; are more likely to have lobectomies than wedge/segmental resections (p<0.001); and have a lower risk of LC death [adjusted SHR, 0.89 (0.85, 0.93)]. Question: Are there opportunities for improving publicpatient outcomes? (3) Patients born in non-English speaking countries have lower odds of localised disease [adjusted OR, 0.88 (0.79, 0.99)]. – Question: Could this difference be decreased by reducing cultural and language barriers? (4) Cancers of pulmonary lobes rather than the main bronchus pose lower risks of LC death. Question: Could outcomes for main bronchus cancers be improved by up-skilling or referral to higher-volume centres? (5) Greater extent of disease is strongly predictive of case fatality – Question: Could LC deaths be reduced by earlier treatment? (6) Use of lobectomies varies – Question: Could survival be increased through greater use of lobectomies for localised NSCLC?
Conclusions: Linked cancer registry and hospital data can increase system-wide understanding of local health-service delivery and prompt discussion points on how to improve outcomes.
Abbreviations: APDC – Australian Patient Data Collection; CHeReL – Centre for Health Record Linkage; EOD – Extent of Disease; LC – Lung Cancer; NSCLC – Non-Small Cell Cancers; NSWCR – New South Wales Cancer Registry; OR – Relative Odds; SEIFA – Socio-Economic Index for Areas; SES – Socio- Economic Status.