bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investor Sentiment, Misstatements, and Auditor Behavior*
Authors: Amin Keval , Eshleman John Daniel , Guo Peng 
Published: May 2020

ABSTRACTHigh investor sentiment has been linked with opportunistic managerial behavior in the face of more optimistic investors and analysts. We extend this line of work by documenting that the likelihood of misstatements is higher when sentiment is high. Although this would suggest elevated audit risk, we posit that a contemporaneous reduction in auditors' litigation cost could drive down audit fees and going concern opinion (GCO) reporting conservatism in order to please clientele. Consistent with this notion, we document that auditors charge lower fees and report GCOs less conservatively when sentiment is high. However, this reduction in reporting conservatism is unwarranted; results reveal that auditors are less likely to issue GCOs to clients which subsequently file for bankruptcy during high sentiment periods. We conduct additional tests to examine whether auditors' litigation costs indeed vary with sentiment and document that auditors are less likely to be sued and the market reacts less negatively to misstatement announcements when sentiment is high. Collectively, our findings suggest that, although misstatement risk is increasing with sentiment, auditors' litigation risk actually declines.
Determination of adequate positive end‐expiratory pressure level required for carbon dioxide homeostasis in an animal model of infant laparoscopy
Authors: Karlsson Jacob , Fodor Gergely H. , dos Santos Rocha Andre , Lin Na , Habre Walid , Wallin Mats , Hallbäck Magnus , Peták Ferenc , Lönnqvist Per‐Arne 
Published: May 2020

BackgroundCapnoperitoneum provides a ventilatory challenge due to reduction in end‐expiratory lung volume and peritoneal carbon dioxide absorption in both children and adults. The primary aim of this controlled interventional trial was to determine the positive end‐expiratory pressure (PEEP) level needed to ensure for adequate carbon dioxide clearance and preservation of carbon dioxide homeostasis in an experimental model of infant laparoscopy. The secondary aim was to evaluate potential effects on cardiac output of PEEP and abdominal pressure level variations in the same setting.MethodsEight chinchilla bastard rabbits were anesthetized and mechanically ventilated. Intra‐abdominal pressures were randomly set to 0, 6, and 12 mm Hg by carbon dioxide insufflation. Carbon dioxide clearance using volumetric capnography, arterial blood gas data, and cardiac output was recorded, while PEEP 3, 6, and 9 cmH2O were applied in a random order.ResultsA PEEP of 9 cmH2O showed restoration of carbon dioxide clearance without causing changes in arterial partial pressure of carbon dioxide and bicarbonate and with no associated deterioration in cardiac output.ConclusionThe results promote a PEEP level of 9 cmH2O in this model of infant capnoperitoneum to allow for adequate carbon dioxide removal with subsequent preservation of carbon dioxide homeostasis. The use of high PEEP was not associated with any decrease in cardiac output.
Epidural vs. transversus abdominis plane block for abdominal surgery – a systematic review, meta‐analysis and trial sequential analysis
Authors: Desai N. , El‐Boghdadly K. , Albrecht E. 
Published: May 2020

SummaryTraditionally, pain relief for abdominal surgery has centred on epidural analgesia, but transversus abdominis plane block is increasingly being used. Our aim was to compare the analgesic efficacy and the side‐effect profile of transversus abdominis plane block with epidural analgesia in a systematic review with meta‐analysis and trial sequential analysis. After a systematic search of the electronic databases, we identified 18 randomised controlled trials with 1220 patients. Confirmed by trial sequential analysis, our first co‐primary outcome, postoperative pain score at rest at 12 h, was decreased by a mean difference (95%CI) of 0.69 (0.12–1.27; p = 0.02) with epidural analgesia compared with transversus abdominis plane block, with the quality of evidence graded as low. No difference was found for the second co‐primary outcome, postoperative pain score at rest at 24 h, with the quality of evidence rated as very low. Relative to transversus abdominis plane block, epidural analgesia further reduced the need for intravenous morphine‐equivalent consumption during the 0–24 h interval by a mean difference (95%CI) of 5.91 mg (2.34–9.49; p = 0.001) at the expense of an increased incidence of hypotension at 72 h, with a risk ratio (95%CI) of 5.88 (2.08–16.67; p < 0.001). Our meta‐analysis was limited by detection and performance bias, significant statistical heterogeneity and publication bias. In view of the minimal clinically important difference in postoperative pain scores, epidural analgesia was interpreted to not be clinically different to transversus abdominis plane block after abdominal surgery. With transversus abdominis plane block, the increase in intravenous morphine‐equivalent consumption at 24 h should be balanced against the decreased risk of hypotension at 72 h. In choosing between epidural analgesia and transversus abdominis plane block, potential benefits should be balanced against the reported risk of harm, although the confidence in the evidence varied, underlining the uncertainty in our estimates.
The Outsider
Authors: Balaswaminathan Sowparnika 
Published: May 2020

SummaryThe practice of ethnography relegates the anthropologist to an interstitial space of belonging, even when the anthropologist is of the community. This experience is not unique to anthropology, as anyone living a life of intersectionality faces competing claims of communal membership, but what is it about the act of observing with distance that turns us into outsiders? This story is inspired by this intersectionality, twice framed, centered on Kathir, a man who belongs between several worlds: the village and town, Hindu and Muslim, dreams and lethargy, youth and adulthood. That he is also the interpreter and the assistant to an anthropologist appends an additional layer of interstitiality, because such middlemen technicians are often elided in the ethnographic narrative. Consequently, this fictional narrative explores themes of belonging and intersectionality, both in terms of anthropology as well as the subject of anthropology, everyday life.
Group‐based multimodal physical therapy in women with chronic pelvic pain: A randomized controlled trial
Authors: Nygaard Ane Sigrid , Rydningen Mona Birgitte , Stedenfeldt Mona , Wojniusz Slawomir , Larsen Marthe , Lindsetmo Rolv‐Ole , Haugstad Gro Killi , Øian Pål 
Published: May 2020

AbstractIntroductionChronic pelvic pain in women is a complex condition, and physical therapy is recommended as part of a broader treatment approach. The objective of this study was to compare structured group‐based multimodal physical therapy in a hospital setting (intervention group) with primary‐care physical therapy (comparator group) for women with chronic pelvic pain.Material and methodsWomen aged 20‐65 years with pelvic pain ≥6 months and referred for physical therapy were eligible. The primary outcome measure was change in the mean pelvic pain intensity from baseline to 12 months, measured using the numeric rating scale (0‐10). Secondary outcomes were changes in scores of “worst” and “least” pain intensity, health‐related quality of life, movement patterns, pain‐related fear of movements, anxiety and depression, subjective health complaints, sexual function, incontinence, and obstructed defecation. The differences between the groups regarding change in scores were analyzed using the independent t test and Mann‐Whitney U test. Sensitivity analysis of the primary outcome was performed with a linear regression model adjusted for the baseline value. A P value <.05 was considered statistically significant.ResultsOf the 62 women included, 26 in the intervention group and 25 in the comparator group were available after 12 months for data collection and analysis. The difference between the groups for change in the mean pain intensity score was −1.2 (95% CI −2.3 to −0.2; P = .027), favoring the intervention group. The intervention group showed greater improvements in respiratory patterns (mean difference 0.9; 95% CI 0.2‐1.6; P = .015) and pain‐related fear of movements (mean difference 2.9; 95% CI −5.5 to −0.3; P = .032), and no significant differences were observed between the groups for the other secondary outcomes.ConclusionsAlthough the reduction in the mean pelvic pain intensity with group‐based multimodal physical therapy was significantly more than with primary‐care physical therapy, the difference in the change between the groups was less than expected and the clinical relevance is uncertain.
Colour vision classification – comparing CAD and CIE 143:2001 International recommendations for colour vision requirements in transport
Authors: Koefoed Vilhelm F. , Miles Tyler , Cason John B. , Troche Ray 
Published: May 2020

AbstractPurposeTo evaluate the colour vision severity classification standard ‘CIE 143:2001 International recommendations for colour vision requirements in transport’ (CIE 143:2001), which has become out of date because of the lack of commercial availability of required colour vision tests.MethodsOne‐hundred‐five subjects had colour vision tested and colour vision severity classified according to a modified CIE 143:2001 algorithm that included pseudoisochromatic plates (Ishihara's test and Hardy Rand Rittler (HRR) 4th edition), Optec 900 lantern and Farnsworth D‐15. Subject's results and colour vision severity classification were compared to performance and colour vision severity classification on the computerized ‘Colour Assessment and Diagnosis’ (CAD) test.ResultsAccording to CIE 143:2001, using Ishihara’s test, Optec lantern and Farnsworth D 15, 11 subjects (10%) were category I (normal), 16 (15%) were category II (mild), 48 (46%) were category III (poor), and 30 (29%) were category IV (severe). Classified by CAD score, 10 (10%) were category I, 11 (10%) were category II, 41 (39%) were category III, and 43 (41%) were category IV. The correlation between the two estimates of the severity of colour vision loss (i.e. CIE 143:2001 and CAD) was high, with a Kendall’s Tau test of 0.81 (τ = 0.81 p < 0.001). A suggested CIE 143:2001 classification including new CAD score limits improves the classification correlation to 0.90 (τ = 0.90 p < 0.001) for all diagnoses.ConclusionThe colour vision severity classification standard ‘CIE 143:2001 International recommendations for colour vision requirements in transport’, has not implemented new diagnostic tools with better accuracy. We propose three possible revisions to the CIE 143:2001 algorithm, based on the availability of CAD: (1) Replacing the current CIE 143:2001 algorithm using new CAD threshold limits, (2) Use of CAD as a secondary test to Ishihara's test and HRR or (3) Revising the current CIE 143:2001 algorithm using Ishihara's test, HRR, Optec 900 and FD15.
The sodium channel NaV1.5 impacts on early murine embryonic cardiac development, structure and function in a non‐electrogenic manner
Authors: Marchal Gerard A. , Verkerk Arie O. , Mohan Rajiv A. , Wolswinkel Rianne , Boukens Bastiaan J. D. , Remme Carol Ann 
Published: May 2020

AbstractAimThe voltage‐gated sodium channel NaV1.5, encoded by SCN5A, is essential for cardiac excitability and ensures proper electrical conduction. Early embryonic death has been observed in several murine models carrying homozygous Scn5amutations. We investigated when sodium current (INa) becomes functionally relevant in the murine embryonic heart and how Scn5a/NaV1.5 dysfunction impacts on cardiac development.MethodsInvolvement of NaV1.5‐generated INa in murine cardiac electrical function was assessed by optical mapping in wild type (WT) embryos (embryonic day (E)9.5 and E10.5) in the absence and presence of the sodium channel blocker tetrodotoxin (30 µmol/L). INa was assessed by patch‐clamp analysis in cardiomyocytes isolated from WT embryos (E9.5‐17.5). In addition, cardiac morphology and electrical function was assessed in Scn5a‐1798insD−/− embryos (E9.5‐10.5) and their WT littermates.ResultsIn WT embryos, tetrodotoxin did not affect cardiac activation at E9.5, but slowed activation at E10.5. Accordingly, patch‐clamp measurements revealed that INa was virtually absent at E9.5 but robustly present at E10.5. Scn5a‐1798insD−/− embryos died in utero around E10.5, displaying severely affected cardiac activation and morphology. Strikingly, altered ventricular activation was observed in Scn5a‐1798insD−/− E9.5 embryos before the onset of INa, in addition to reduced cardiac tissue volume compared to WT littermates.ConclusionWe here demonstrate that NaV1.5 is involved in cardiac electrical function from E10.5 onwards. Scn5a‐1798insD−/− embryos displayed cardiac structural abnormalities at E9.5, indicating that NaV1.5 dysfunction impacts on embryonic cardiac development in a non‐electrogenic manner. These findings are potentially relevant for understanding structural defects observed in relation to NaV1.5 dysfunction.
Entrepreneurial Coaching: A Two‐Dimensional Framework in Context
Authors: Kotte Silja , Diermann Isabell , Rosing Kathrin , Möller Heidi 
Published: May 2020

Coaching is increasingly used to support entrepreneurs across different stages of the entrepreneurial process. Due to its custom‐tailored, active, and reflection‐oriented approach, it has been suggested that it is particularly well suited to entrepreneurs’ complex job demands. However, in the entrepreneurial context, the termcoachinglacks a clear definition and is frequently used interchangeably with other types of support. We therefore sought to characterize entrepreneurial coaching (EC) and to position it relative to related interventions. We conducted 67 interviews with coaches (n = 44) and early‐stage entrepreneurs (n = 23) experienced in EC. Using qualitative content analysis, we specify outcomes, input, process, and contextual factors for EC. Among process factors, we identify seven coach functions that reflect specific coach behaviors. Contextual factors include entrepreneurial job demands and institutional boundary conditions of “embedded” EC. Based on our findings, we position EC within a two‐dimensional framework, consisting of the expert‐ versus process‐consultation approach and the individual‐work‐venture focus. We locate the seven coach functions within this framework. Relative to other interventions, EC stands between classical workplace coaching and start‐up consultancy, closer to, yet distinct from, entrepreneurial mentoring and executive coaching. We derive practical implications for coaches, entrepreneurs, and organizational stakeholders and propose directions for future research.
Impact of granulocyte colony‐stimulating factor on FOLFIRINOX‐induced neutropenia prevention: A population pharmacokinetic/pharmacodynamic approach
Authors: Macaire Pauline , Paris Justine , Vincent Julie , Ghiringhelli François , Bengrine‐Lefevre Leïla , Schmitt Antonin 
Published: May 2020

AimsGranulocyte colony‐stimulating factor (G‐CSF) is frequently prescribed to prevent chemotherapy‐induced neutropenia, but the administration schedule remains empirical in case of bimonthly chemotherapy such as FOLFIRINOX regimen. This pharmacokinetic/pharmacodynamic (PK/PD) study was performed to determine the effect of different G‐CSF regimens on the incidence and duration of neutropenia following FOLFIRINOX administration in order to propose an optimal G‐CSF dosing schedule.MethodsA population PK/PD model was developed to describe individual neutrophil time course from absolute neutrophil counts (ANC) obtained in 40 advanced cancer patients receiving FOLFIRINOX regimen. The structural model considered ANC dynamics, neutropenic effect of cytotoxics and the stimulating effect of G‐CSF on neutrophils. Final model estimates were used to simulate different G‐CSF dosing schedules for 1000 virtual subjects. The incidence and duration of neutropenia were then calculated for different G‐CSF dosing schedules.ResultsThe final model successfully described the myelosuppressive effect induced by the 3 cytotoxics for all patients. Simulations showed that pegfilgrastim administration reduced the risk of severe neutropenia by 22.9% for subjects with low ANC at the start of chemotherapy. Median duration in this group was also shortened by 3.1 days when compared to absence of G‐CSF. Delayed G‐CSF administration was responsible for higher incidence and longer duration of neutropenia compared to absence of administration.ConclusionThe PK/PD model well described our population's ANC data. Simulations showed that pegylated‐G‐CSF administration 24 hours after the end of chemotherapy seems to be the optimal schedule to reduce FOLFIRINOX‐induced neutropenia. We also underline the potential negative effect of G‐CSF maladministration.
Diagnostic conversion from unipolar depression to bipolar disorder, schizophrenia, or schizoaffective disorder: A nationwide prospective 15‐year register study on 43 495 inpatients
Authors: Baryshnikov Ilya , Sund Reijo , Marttunen Mauri , Svirskis Tanja , Partonen Timo , Pirkola Sami , Isometsä Erkki T. 
Published: May 2020

AbstractObjectiveTo examine temporal patterns and predictors for diagnostic conversion from unipolar depression (UD) to bipolar disorder (BD), schizophrenia, and schizoaffective disorder (SAD).MethodsA prospective nationwide register‐based cohort (n = 43 495) of all first psychiatric hospitalizations due to UD during 1996‐2011 was followed up to 15 years. We used cumulative incidence function (CIF) analyses and the Fine‐Gray subdistribution model to define the cumulative incidence of the conversions and subdistribution hazard ratios (SHRs) for predictors.ResultsThe overall 15‐year cumulative incidence of conversion was 11.1% (95% CI 10.7‐11.6): 7.4% (95% CI 7.0‐7.8) for BD, 2.5% (95% CI 2.3‐2.7) for schizophrenia, and 1.3% (95% CI 1.1‐1.4) for SAD. The highest crude incidence rate emerged during the first year. Psychotic depression predicted higher conversion risk to BD (SHR = 2.0, 95% CI 1.5‐2.7), schizophrenia (SHR = 5.3, 95% CI 3.3‐8.7), and SAD (SHR = 10.6, 95% CI 4.0‐28.4) than mild depression. Female sex, greater overall disturbance, and comorbid personality disorder predicted conversion to BD, whereas young age and male sex to psychotic disorders.ConclusionsAmong patients with first hospitalization due to UD, approximately one in nine converts to another major psychiatric disorder during 15 years, with the highest risk occurring within the first year. Patients with psychotic depression are particularly vulnerable for conversion to other major psychiatric disorders. Conversion to psychotic disorders occurs earlier than to BD. Males are at higher risk for progression to psychotic disorders, whereas females, patients with recurrent depressive episodes, severe disturbance of overall functioning, and personality disorder are at higher risk for converting to BD.
Genomic analysis of multiple myeloma using targeted capture sequencing in the Japanese cohort
Authors: Kanamori Takashi , Sanada Masashi , Ri Masaki , Ueno Hiroo , Nishijima Dai , Yasuda Takahiko , Tachita Takuto , Narita Tomoko , Kusumoto Shigeru , Inagaki Atsushi , Ishihara Rei , Murakami Yuki , Kobayashi Nobuhiko , Shiozawa Yusuke , Yoshida Kenichi , Nakagawa Masahiro M. , Nannya Yasuhito , Shiraishi Yuichi , Chiba Kenichi , Tanaka Hiroko , Miyano Satoru , Horibe Keizo , Handa Hiroshi , Ogawa Seishi , Iida Shinsuke 
Published: May 2020

SummaryPrevious genomic studies have revealed the genomic landscape of myeloma cells. Although some of the genomic abnormalities shown are believed to be correlated to the molecular pathogenesis of multiple myeloma and/or clinical outcome, these correlations are not fully understood. The aim of this study is to elucidate the correlation between genomic abnormalities and clinical characteristics by targeted capture sequencing in the Japanese multiple myeloma cohort. We analysed 154 patients with newly diagnosed multiple myeloma. The analysis revealed that the study cohort consisted of a less frequent hyperdiploid subtype (37·0%) with relatively high frequencies of KRAS mutation (36·4%) and IGH‐CCND1 translocation (26·6%) compared with previous reports. Moreover, our targeted capture sequencing strategy was able to detect rare IGH‐associated chromosomal translocations, such as IGH‐CCND2 and IGH‐MAFA. Interestingly, all 10 patients harboured MAX mutations accompanied by 14q23 deletion. The patients with del(17p) exhibited an unfavourable clinical outcome, and the presence of KRAS mutation was associated with shorter survival in patients with multiple myeloma, harbouring IGH‐CCND1. Thus, our study provides a detailed landscape of genomic abnormalities, which may have potential clinical application for patients with multiple myeloma.
Detrital zircon age spectra of middle and upper Eocene outcrop belts, U.S. Gulf Coast region
Authors: Craddock William H. , Coleman James L. , Kylander‐Clark Andrew R. C. 
Published: May 2020

AbstractRecently reported detrital zircon (DZ) data help to associate the Paleogene strata of the Gulf of Mexico region to various provenance areas. By far, recent work has emphasised upper Paleocene‐lower Eocene and upper Oligocene strata that were deposited during the two episodes of the highest sediment supply in the Paleogene. The data reveal a dynamic drainage history, including (1) initial routing of western Cordilleran drainages towards the Gulf of Mexico in the Paleocene, (2) an eastward shift of the western continental divide, from the Jura‐Cretaceous cordilleran arc to the eastern edge of the Laramide province after the Paleocene and (3) a southward shift, along the eastern Laramide province, of the headwaters of river systems draining to the Mississippi and Houston embayments at some time between the early Eocene and Oligocene. However, DZ characterisation of most (~20 Myr) of the middle Eocene‐lower Oligocene section remains limited. We present 60 DZ age spectra, most of which are from the middle or upper Eocene outcrop belts, with 50–200‐km spacing. We define six to eight distinct groups of DZ age spectra for middle and upper Eocene strata. Data from this and other studies resolve at least six substantial temporal changes in age spectra at various positions along the continental margin. The evolving age spectra constrain the middle and upper Eocene drainage patterns of large parts of interior North America. The most well‐resolved aspects of these drainage patterns include (1) persistent rivers that flowed from erosional landscapes across the Paleozoic Appalachian orogen either into the low‐lying Mississippi embayment or directly into the eastern Gulf; (2) at least during marine regressions, a trunk channel that likely flowed southward along the axial part of Mississippi Embayment and integrated tributaries from the east and west; and (3) rivers that flowed to the Houston embayment in the middle Eocene that likely originated in the Laramide province in central Colorado and southern Wyoming, as Precambrian basement highs in those source areas were being unroofed.