bluuebunny/crossref_metadata_2025_split huggingface dataset:
Right ventricular phenotype, function, and failure: a journey from evolution to clinics
Authors: Taverne Yannick J. H. J. , Sadeghi Amir , Bartelds Beatrijs , Bogers Ad J. J. C. , Merkus Daphne 
Published: June 2020

AbstractThe right ventricle has long been perceived as the “low pressure bystander” of the left ventricle. Although the structure consists of, at first glance, the same cardiomyocytes as the left ventricle, it is in fact derived from a different set of precursor cells and has a complex three-dimensional anatomy and a very distinct contraction pattern. Mechanisms of right ventricular failure, its detection and follow-up, and more specific different responses to pressure versus volume overload are still incompletely understood. In order to fully comprehend right ventricular form and function, evolutionary biological entities that have led to the specifics of right ventricular physiology and morphology need to be addressed. Processes responsible for cardiac formation are based on very ancient cardiac lineages and within the first few weeks of fetal life, the human heart seems to repeat cardiac evolution. Furthermore, it appears that most cardiogenic signal pathways (if not all) act in combination with tissue-specific transcriptional cofactors to exert inductive responses reflecting an important expansion of ancestral regulatory genes throughout evolution and eventually cardiac complexity. Such molecular entities result in specific biomechanics of the RV that differs from that of the left ventricle. It is clear that sole descriptions of right ventricular contraction patterns (and LV contraction patterns for that matter) are futile and need to be addressed into a bigger multilayer three-dimensional picture. Therefore, we aim to present a complete picture from evolution, formation, and clinical presentation of right ventricular (mal)adaptation and failure on a molecular, cellular, biomechanical, and (patho)anatomical basis.
Illness Perceptions in Pediatric Spinal Muscular Atrophy: Agreement between Children and their Parents, and its Association with Quality of Life
Authors: Fischer M. J. , Ketelaar M. , van der Veere P. J. , Verhoef M. , Wadman R. I. , Visser-Meily J. M. A. , van der Pol W. L. , Schröder C. D. 
Published: June 2020

AbstractIn adults with neuromuscular conditions illness perceptions show a strong relation with QoL. For young patients, illness perceptions are shaped through interaction with their parents. A shared perception between child and parent may benefit the child’s QoL. This study investigated agreement in illness perceptions of children with Spinal Muscular Atrophy (SMA) and their parents, the association between the child’s illness perceptions and QoL, and the relation between child-parent agreement in illness perceptions and the child’s QoL. Twenty-six children and their parents completed the Brief Illness Perception Questionnaire (BIPQ) and the Kidscreen-52 QoL questionnaire (children only). Correspondence between children’s and parents’ illness perceptions was low. Generally, parents held more negative illness perceptions about SMA. Whereas children’s illness perceptions were related to QoL, no clear association was found between agreement in illness perceptions and children’s QoL. Therefore, to understand and improve QoL, healthcare professionals should discuss children’s own illness perceptions during consultations.
Complexity and potentials of clinical feedback in mental health: an in-depth study of patient processes
Authors: Solstad Stig Magne , Kleiven Gøril Solberg , Moltu Christian 
Published: June 2020

Abstract
Purpose
Routine outcome monitoring (ROM) and clinical feedback systems (CFS) are becoming increasingly prevalent in mental health services. Their overall efficacy is unclear, but quantitative evidence suggests they can be useful tools for preventing treatment failure and enhancing therapeutic outcomes, especially for patients who are not progressing in therapy. The body of qualitative material, however, is smaller and less refined. We need to know more about how ROM/CFS is used in psychotherapy, and why it is helpful for some patients, but not others.

Methods
We recorded therapy sessions of 12 patients who were using a CFS as part of their therapies at an outpatient clinic in Norway. We then conducted video-assisted interviews and follow-up interviews with patients. Data were analyzed with systematic text condensation.

Results
Analysis revealed three themes: (1) triggering reflections, emotions, and self-awareness, (2) Ambivalent and ambiguous self-presentation, and (3) potential for feeling understood and talking about what matters.

Conclusion
Answering questions in a CFS is an interpretative and intentional process of self-presentation and the results from ROM/CFS must be interpreted and explored in conversation to be clinically useful. When they are, they have potential for enhancing the therapeutic process by stimulating self-awareness, reflexivity, and allowing access to new therapeutic topics. Further research should explore this how-to aspect of ROM/CFS with different CFS and different types of patients. Integrating clinical feedback in therapeutic practice can be conceptualized as a clinical skill, which should be a part of training programs for therapists.
Benchmarking stateless NAT64 implementations with a standard tester
Authors: Lencse G. 
Published: June 2020

AbstractRFC 5180, the IPv6 update of RFC 2544, declared IPv6 transition technologies out of its scope. RFC 8219 defined a benchmarking methodology for IPv6 transition technologies including stateless NAT64 (more properly called SIIT) in the category of single translation solutions. Whereas several research papers have dealt with the performance of different stateful NAT64 implementations, none of them used RFC 8219 compliant measurements or addressed stateless NAT64 implementations. In this paper, we show, how stateless NAT64 implementations can be benchmarked carrying out the most important tests recommended by RFC 8219 without a special purpose NAT64 Tester, using simply an RFC 2544/RFC 5180 compliant legacy Tester. We carry out benchmarking measurements to examine the performance of three free software NAT64 implementations, namely: Jool, TAYGA and map646. All the details of our measurements are disclosed and their results are presented in the paper.
What is it going to cost? Empirical evidence from a systematic literature review of audit fee determinants
Authors: Widmann Markus , Follert Florian , Wolz Matthias 
Published: June 2020

AbstractThe audit market is subject to ongoing regulation to ensure or improve the quality of audit services. For this reason, international research on the audit market is highly popular. As part of this discussion, pricing is considered one of the most relevant aspects of audits. However, a remarkable heterogeneity of the control variables used in empirical studies can be observed. Prior meta-analyses on audit fees already summarized and categorized them for audit fee studies covering financial periods until fiscal year 2007. We contribute to the international literature with an up-to date and systematic review approach on audit fee studies published in international relevant scientific journals (JQ3 A + , A, B). In addition to prior reviews and meta-analyses, we finally suggest a standard model for the most important fee drivers that can be used for future audit fee studies. Our unique approach is based on an EBSCO keyword search with a sample of 385 papers published in international relevant scientific journals (JQ3 A + , A, B) and is using a scoring model to assess significance of audit fee control variables. On the one hand, we enrich the literature by a new state of the art paper on pricing within audit firms. On the other hand, we contribute to the international literature on audit markets from a theoretical point of view by deriving a new testable model of audit fee determinants. Therefore, our empirical results provide several fundamental insights that can be used for further empirical and theoretical research on the pricing of audit services. Thus, the results are meaningful not only for researchers within the field of auditing but also for experts in management, pricing or European legislature.
Characterizing the heterogeneous correlations between the landscape patterns and seasonal variations of total nitrogen and total phosphorus in a peri-urban watershed
Authors: Li Chongwei , Zhang Haiyan , Hao Yonghong , Zhang Ming 
Published: June 2020

AbstractLandscape patterns in a watershed potentially have significant influence on the occurrence, migration, and transformation of pollutants, such as nitrogen (N) and phosphorus (P) in rivers. Human activities can accelerate the pollution and complicate the problem especially in a peri-urban watershed with different types of land use. To characterize the heterogeneous correlations between landscape patterns and seasonal variations of N and P in a peri-urban watershed located upstream of Tianjin metropolis, China, observations of total nitrogen (TN) and total phosphorus (TP) at 33 locations were performed in the wet and dry seasons from 2013 to 2016. The data from individual locations were averaged for the wet and dry seasons and analyzed with geographical detector to identify influential landscape indices on seasonal water quality variations. The geographically weighted regression method, capable of analyzing heterogeneous correlations, was used to evaluate the integrated effects from different landscape indices. The results demonstrated that the location-weighted landscape contrast index (LWLI), the ratio of urban areas, and the ratio of forest areas were major influential indicators that affected TN and TP in river water. These indices also had integrated effects on variations of TN and TP together with other indices such as Shannon diversity index, landscape shape index, largest patch index, and contagion index. The integrated effects were different in the wet and dry seasons because of different effects of flushing and dilution by rainwater and the heterogeneity in landscape patterns. The LWLI had a positive relationship to water quality in the areas with high ratio of urban areas, indicating that domestic wastewater can be a major source of N and P pollution. The approaches and findings of this study may provide a reference for characterizing the major factors and integrated effects that control nonpoint source pollution in a watershed.
Distance to landfill and human activities affects the debris incorporation into the white stork nests in urbanized landscape in central Spain
Authors: Jagiello Zuzanna , López-García Alejandro , Aguirre José I. , Dylewski Łukasz 
Published: June 2020

AbstractHuman’s activities dominates many aspects of the Earth’s environment; thus animals are forced to adapt and respond to the resulting changes in habitat structure and functioning due to anthropogenic pressure. Along with the growing human population and the associated amount of waste produced, the amount of different type of physical contamination component in environment is increasing. Incorporation of debris in nests may be a mounting avian response to anthropogenic pollution. In this research, we quantified the constituent pieces and total mass of human-derived materials incorporated in white stork nests. The study was conducted on four locations in central Spain where white storks nest along a urbanization gradient. In total, we examined 49 nests. This study demonstrates that the incorporation of debris by white storks into their nests is related to human activity, measured by the Human Footprint Index (HFI). Moreover, the distance between these nests and landfills predicts the occurrence of debris incorporated into nests. Our study shows that birds nest building behaviour is impacted by human activities and pollution in environment.
Parsimonious powertrain modeling for environmental vehicle assessments: part 2—electric vehicles
Authors: Geyer Roland , Malen Donald E. 
Published: June 2020

Abstract
Purpose
Environmental assessments of electric vehicles (EV) require scientifically sound and robust fuel consumption models. The purpose of this paper is to introduce a novel method and model for calculating energy demand of battery electric (BEV) and series plug-in hybrid electric (PHEV) vehicles.

Methods
This paper presents an open-source simulation model for BEV and series PHEV powertrains. It is based on driving and powertrain physics, such as a net force approach to calculate force demand at the tire patch, and the use of motor maps to model motor efficiency. The modeling approach is well suited to include important EV powertrain aspects, such as regenerative braking and battery charging and discharging losses.

Results
The presented method provides parsimonious open-source EV powertrain modeling to the environmental assessment community. It enables the calculation of vehicle energy demand (in MJ/100 km) and so-called energy reduction values (in MJ/100 km and 100 kg vehicle mass reduction) that are specific to each EV configuration and design change.

Conclusions
The presented EV powertrain model complements the ICV powertrain model introduced in part 1 of this paper series. It uses the same modeling methods as the ICV model, which gives it the same modeling advantages, and also facilitates environmental comparisons across powertrain types.
Tracking and visualization of the sensing area for a tethered laparoscopic gamma probe
Authors: Huang Baoru , Tsai Ya-Yen , Cartucho João , Vyas Kunal , Tuch David , Giannarou Stamatia , Elson Daniel S. 
Published: June 2020

Abstract
Purpose
In surgical oncology, complete cancer resection and lymph node identification are challenging due to the lack of reliable intraoperative visualization. Recently, endoscopic radio-guided cancer resection has been introduced where a novel tethered laparoscopic gamma detector can be used to determine the location of tracer activity, which can complement preoperative nuclear imaging data and endoscopic imaging. However, these probes do not clearly indicate where on the tissue surface the activity originates, making localization of pathological sites difficult and increasing the mental workload of the surgeons. Therefore, a robust real-time gamma probe tracking system integrated with augmented reality is proposed.

Methods
A dual-pattern marker has been attached to the gamma probe, which combines chessboard vertices and circular dots for higher detection accuracy. Both patterns are detected simultaneously based on blob detection and the pixel intensity-based vertices detector and used to estimate the pose of the probe. Temporal information is incorporated into the framework to reduce tracking failure. Furthermore, we utilized the 3D point cloud generated from structure from motion to find the intersection between the probe axis and the tissue surface. When presented as an augmented image, this can provide visual feedback to the surgeons.

Results
The method has been validated with ground truth probe pose data generated using the OptiTrack system. When detecting the orientation of the pose using circular dots and chessboard dots alone, the mean error obtained is $$0.05^{\circ }$$

0
.

05
∘

and $$0.06^{\circ }$$

0
.

06
∘

, respectively. As for the translation, the mean error for each pattern is 1.78 mm and 1.81 mm. The detection limits for pitch, roll and yaw are $$360^{\circ }, 360^{\circ }$$

360
∘

,

360
∘

and $$8^{\circ }$$

8
∘

–$$82^{\circ }\cup 188^{\circ }$$

82
∘

∪

188
∘

–$$352^{\circ }$$

352
∘

.

Conclusion
The performance evaluation results show that this dual-pattern marker can provide high detection rates, as well as more accurate pose estimation and a larger workspace than the previously proposed hybrid markers. The augmented reality will be used to provide visual feedback to the surgeons on the location of the affected lymph nodes or tumor.
Die Repräsentation der Bürgerinnen und Bürger durch organisierte Interessen in Deutschland
Authors: Pakull Dominic , Goldberg Felix , Bernhagen Patrick 
Published: June 2020

ZusammenfassungIn dieser Studie analysieren wir das Potenzial organisierter Interessen als Transmissionsriemen zwischen der Bevölkerung und politischen Institutionen im parlamentarischen System der Bundesrepublik zu fungieren. Wir verwenden Daten aus Experteninterviews mit Lobbyistinnen und Lobbyisten und einer repräsentativen Bevölkerungsumfrage, um die Kongruenz zwischen den Themenfeldern zu ermitteln, welche die Bürgerinnen und Bürger und organisierten Interessen in Deutschland jeweils als wichtig ansehen. Ferner analysieren wir, ob sich die Kongruenz hinsichtlich der öffentlichen Salienz des Themas sowie des soziökonomischen Status oder der politischen Einstellungen der Bürgerinnen und Bürger unterscheidet. Dabei differenzieren wir zwischen Unternehmer- und Nichtunternehmerinteressen. Die Ergebnisse deuten auf eine moderate Themenkongruenz zwischen den Agenden der Bürgerinnen und Bürger und der organisierten Interessen hin. Diese Repräsentationsleistung wird jedoch überwiegend von Nichtunternehmerorganisationen erfüllt, die verstärkt an Themen arbeiten, die für die Bevölkerung salient sind. Ferner sind Bürgerinnen und Bürger mit extremeren Einstellungen besser repräsentiert als jene, die sich in der ideologischen Mitte befinden. Hingegen zeigen sich keine Unterschiede hinsichtlich des Einkommens und Geschlechts oder zwischen Ost- und Westdeutschland.
Combining participatory games and backcasting to support collective scenario evaluation: an action research approach for sustainable agroforestry landscape management
Authors: Andreotti Federico , Speelman Erika N. , Van den Meersche Karel , Allinne Clementine 
Published: June 2020

AbstractThe combined and interacting effects of land-use change, resource extraction and climate change threaten the sustainability of millions of mainly smallholder farms in tropical agroforested landscapes. In many of these landscapes, coordinated action among stakeholders at landscape level would help to address challenges such as pests and diseases, price crises and climate change. However, methods to facilitate the co-production of sustainable landscape management in such complex multi-stakeholder systems are currently largely lacking. In this paper, we present a novel approach to explore pathways for the sustainability transition of agroforestry systems. By combining participatory forecasting and backcasting approaches, based on serious games and future vision development, we explore relevant agroforestry management strategies for reaching sustainable future coffee-based agroforestry landscapes. We focused our research on the challenges faced in the main coffee-producing area in Nicaragua. Here, we organized five participatory game sessions to explore farmer decision-making processes, farming strategies and to develop new networks and stimulate social learning among farmers. In the associated backcasting workshop, the most influential game session participants joined technicians, researchers and municipality officials to collectively envision sustainable future landscape management. In all game sessions, farmers developed diversified coffee-based agroforested landscapes characterised by increased density and diversity of shade trees, for the purpose of income diversification as well as forest conservation. During the backcasting workshop, the participants identified policy instruments and community-based solutions for the transition to sustainable landscapes. Our participatory approach facilitated discussion on landscape planning among farmers and other stakeholders and allowed the outline of a pathway towards the collective envisioned future landscape. The combination of participatory forecasting and backcasting proved to be a helpful tool to support multi-stakeholder processes towards sustainable landscape management in this and other complex landscapes.
Lead (Pb) Accumulation in Human THP-1 Monocytes/Macrophages In Vitro and the Influence on Cell Apoptosis
Authors: Metryka Emilia , Kupnicka Patrycja , Kapczuk Patrycja , Aszakiewicz Beata , Piotrowska Katarzyna , Tkacz Marta , Gutowska Izabela , Chlubek Dariusz , Baranowska-Bosiacka Irena 
Published: June 2020

AbstractIn this study, we investigated the ability of THP-1 monocytes and macrophages to accumulate lead (Pb) in vitro, relative to Pb concentration and length of exposure. Moreover, we also evaluated the effect of Pb accumulation on cell viability and apoptosis. THP-1 monocytes and macrophages were cultured in the presence of Pb at 1.25 μg/dL, 2.5 μg/dL, 5 μg/dL, and 10 μg/dL. Pb accumulation was examined by inductively coupled plasma and confocal microscopy. The influence of Pb on cell viability, apoptosis, and necrosis was assessed using flow cytometry. The results showed that Pb was toxic to THP-1 monocytes/macrophages even at very low environmental concentrations. Despite the use of low concentrations, both monocytes and macrophages showed dose-dependent and time-dependent decreases in viability, with a simultaneous increase in the percentage of early and late apoptotic cells. Macrophages reacted more strongly to Pb than monocytes. When exposed to the same Pb concentrations, they showed lower viability and a higher percentage of necrotic cells. The incubation time positively correlated with Pb accumulation in a dose-dependent manner. The obtained results indicate that environmental exposure to low Pb concentrations may significantly impair the function of macrophages, with the increased number of apoptotic cells potentially contributing to the development of many pathologies in the brain and whole body.