bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blast-induced ground motion effect on dynamic response of a cylindrical vertical water tank with piled raft foundation
Authors: Hacıefendioğlu Kemal , Demir Gökhan , Altunışık Ahmet Can 
Published: September 2020

This paper studies to estimate the dynamic behavior of a demineralized water tank with a piled raft foundation system considering soil-pile-structure-fluid interaction to shock-ground motion. A three-dimensional finite element model of a coupled system is constituted in ANSYS software. Interaction between pile and soil is represented with the frictional contact element. The frictionless contact elements are utilized to model between the water and tank shell to allow for displacement of the free surface adjacent to the tank wall. Shell elements are used for the tank body and its vault. The dynamic analyses of the tank including soil-pile-structure-fluid interaction are presented by using shock response spectra. Ground shock acceleration time histories, generated by using a developed computer program based on Fortran programming language, produce shock response spectra. The effects of the different charge weights and distances from the charge center are examined in the analyses. Also, the effect of the water fill level in the tank and the number of piles is also investigated. The results of the research are presented with the directional displacements and equivalent stresses. It seen from the analyses that the dynamic responses of the tank increase with the charge weight, while decreasing with the charge center distance. Moreover, the water fill level and the number of piles extremely affect the displacement and stress values of the coupled interaction system.
The Effect of Different Thyroxine Hormone (T4) Concentration on The Growth, Survival, and Pigment Development of Pink Zebra Fish Larvae (Brachydanio reiro)
Authors: Heraedi Arifianto , Prayitno Slamet Budi , Yuniarti Tristiana 
Published: September 2020

The thyroxin hormone plays an important role in the process of metabolism, yolk sac absorbsion, and growth of fish. The aims of this research were to observe the effect of various concentration of thyroxin (T4) on the absolute growth weight, total length, survival rate, and pigment development of pink zebra fish larvae (Brachydanio reiro ) after being reared 42 days. The pink zebra fish larvae at 4 day age with the average weight of 0,002 – 0,003g and average length of ± 3.10 – 3.43 mm were immersed at various concentration of T4 for 24 hours. Prior the treatment fish larvae were dipped into 1 ppt salinity for 2 minutes then transferred into 1 Liter, 1ppt saline and various T4 in plastic bags. The thyroxin concentrations were A (0 mg / L); B (0.05 mg / L); C (0.10 mg / L) and D (0.15 mg / L) respectively. The stocking density was 40 fish/L. After that they were transferred into aquariums and reared for 42 days. Completely Randomized Design (RAL) with four treatments and three replications were used. The variables observed were absolute and specific growth, total length, survival rate and hue degree. The results showed that the thyroxin hormone had significant effect on absolute growth weight, total length and specific growth rate. The dosage 0.1 mg/L was the best treatment on absolute growth, total length, and specific growth rate. Whilee the survival rate showed no significant differences across the treatments. Treatment C also demonstrated the best ppigment development (14.60 + 0.36º hue) compared to others.
Perbedaan Kepercayaan Diri Pada Siswa yang Mengikuti Ekstrakurikuler Olahraga
Authors: Kamnuron Andri , Hidayat Yusuf , Nuryadi Nuryadi 
Published: September 2020

Prestasi dalam olahraga dapat ditingkatkan apabila seseorang memiliki rasa percaya diri yang baik, terutama pada olahraga beregu maupun olahraga perorangan. Oleh karena itu penting untuk mengkaji tingkat kepercayaan diri yang dimiliki oleh atlet cabang olahraga beregu ataupun cabang olahraga perorangan. Tujuan dari penelitian ini yaitu untuk membandingkan tingkat kepercayaan diri siswa yang mengikuti ekstrakurikuler olahraga beregu dengan siswa yang mengikuti ekstrakurikuler olahraga perorangan. Metode pada penelitian ini mengguakan metode deskrptif dengan instrumen peneliitan berupa angket kepercayaan diri. Populasi dan sampel berjumlah 30 orang dengan rincian siswa-siswi yang mengikuti ekstrakurikuler cabang olahraga beregu sepak bola berjumlah 15 orang dan siswa-siswi yang mengikuti ekstrakurikuler olahraga perorangan karate berjumlah 15 orang. Hasil analisis menunjukan bahwa siswa yang mengikuti ekstrakurikuler beregu dan perorangan memiliki tingkat kepercayaan diri yang baik, akan tetapi siswa yang mengikuti ekrakurikuler olaraga beregu sepak bola meiliki tingkat kepercayaan diri yang lebih baik dibandingkan dengan siswa yang mengikuti ekstrakurikuler olahraga perorangan karate. Kesimpulan penelitian ini yaitu tidak tedapat perbedaan yang signifikan pada tingkat percaya diri pada siswa ekstrakurikuler olahraga beregu maupun perorangan di SMAN 1 Jatinangor. Saran dari penelitian ini rasa percaya diri perlu dimiliki dan ditingkatkan pada diri siswa untuk menunjang prestasi yang diperoleh pada bidang pendidikan maupun olahraga.
Innate-like T Cells in the Context of Metabolic Disease and Novel Therapeutic Targets
Authors: van der Woude Hannah , Krebs Jeremy , Filoche Sara , Gasser Olivier 
Published: September 2020

Abstract
Metabolic diseases continue to rise in global prevalence. Although there is evidence that current methods of treatment are effective, the continued rise in prevalence indicates that alternative, more efficient treatment options are needed. Over the last several years, immune cells have been increasingly studied as important players in the development of a range of diseases, including metabolic diseases such as obesity and obesity-induced type 2 diabetes. This review explores how understanding the intrinsic metabolism of innate-like T cells could provide potential targets for treating metabolic disease, and highlights research areas needed to advance this promising therapeutic approach.
Open Tibial Shaft Fractures
Authors: Albright Patrick D. , MacKechnie Madeline C. , Roberts Heather J. , Shearer David W. , Padilla Rojas Luis G. , Segovia Julio , Quintero Jose Eduardo , Amadei Rafael , Baldy dos Reis Fernando , Miclau Theodore ,   and the ACTUAR Open Tibia Study Group
Published: September 2020

Background:
Open tibial shaft fractures are an important source of disability in Latin America. High-income countries (HICs) worldwide have established standardized treatment protocols for open tibial fractures, but less is known about their treatment in middle-income countries (MICs) in Latin America. This survey of Latin American orthopaedic surgeons characterizes open tibial fracture treatment patterns.

Methods:
Orthopaedic surgeons from 20 national orthopaedic societies throughout Latin America completed an online survey assessing their treatment of open tibial fractures. Demographic information was collected. Treatment patterns were queried according to 2 groupings of Gustilo-Anderson (GA) fracture types: treatment of type-I and type-II fractures (GA-I/II) and treatment of type-III fractures (GA-III). Treatment patterns were evaluated across 4 domains: antibiotic prophylaxis, irrigation and debridement, fracture stabilization, and wound management. Summary statistics were reported; analysis was performed using the Fisher exact test (p < 0.05).

Results:
There were 616 survey participants from 20 Latin American countries (4 HICs and 16 MICs). Initial external fixation followed by staged internal fixation was preferred for GA-I/II (51.0%) and GA-III fractures (86.0%). Nearly one-third (31.5%) of GA-IIIB fractures did not receive a soft-tissue coverage procedure. Stratifying by country socioeconomic status, surgeons in MICs more commonly utilized delayed internal fixation for GA-I/II (53.3% versus 22.0%, p < 0.001) and GA-III fractures (94.0% versus 80.4%, p = 0.002). Surgeons in MICs more commonly used primary closure for GA-I/II (88.9% versus 62.8%, p < 0.001) and GA-III fractures (32.6% versus 9.8%, p < 0.001).

Conclusions:
This survey reports Latin American orthopaedic surgeons’ treatment patterns for open tibial shaft fractures. Surgeons in MICs reported higher delayed internal fixation use for all fracture types, while surgeons in HICs more routinely avoid primary closure. Soft-tissue coverage procedures are not performed in nearly one-third of GA-IIIB fractures because of a lack of operative personnel and training.
Impact of Organizational Commitment on Employee Performance with Organizational Citizenship Behavior as an Intervening Variable in Transportation Companies in Sidoarjo, Indonesia
Authors: Makhfudho Silvya , Abadiyah Rifdah 
Published: September 2020

This study aims to determine the effect of Competency and Organizational Commitment on Employee Performance through Organizational Citizenship Behavior (OCB) at PT. Mentari Trans Nusantara in Sidoarjo. The analytical tool used is tabulating the questionnaire, collecting data in the form of a validity test and a reliability test. The hypothesis in this study is that there is an influence of Competence and Organizational Commitment on Employee Performance. There is an influence of Organizational Competence and Commitment on Organizational Citizenship Behavior (OCB). There is an influence of Organizational Competence and Commitment on Employee Performance through Organizational Citizenship Behavior (OCB). To test this hypothesis a data analysis tool is used in the form of a t-statistic test. The results obtained by the validity test showed that all statements were said to be valid. And for the reliability test of all variables is said to be reliable. For the hypothesis test based on the t-statistic test showed that there was a significant influence between competence and organizational commitment on Organizational Citizenship Behavior (OCB) and Employee Performance.
The Role of Organizational Commitment and Work Stress on Nurse Performance
Authors: Fatchurohman Mochammad , Abadiyah Rifdah 
Published: September 2020

This study aims to determine the effect of Organizational Culture, Organizational Commitment, Work Stress and Burnout on the Performance of Nurses at the Siti Khodijah Muhammadiyah Hospital Sepanjang branch - Sidoarjo. This research includes quantitative research with hypothesis testing. The samples used in this study were 67 nurses at the Siti Khodijah Muhammadiyah Hospital Sepanjang branch - Sidoarjo. The analysis used is the multiple linear regression test ,F test, t test, multiple correlation coefficient test (R), and the coefficient of determination test (R2) which is tested using SPSS version 18.0 for windows. This primary data is obtained from a questionnaire whose test uses a Likert scale that is tested for validity and reliability and the data is declared valid and reliable. The results of this study prove that Organizational Culture, Organizational Commitment, Work Stress and Burnout simultaneously significantly influence Nurse’s Performance. Organizational Culture has a significant partial effect on Nurse Performance, Organizational Commitment has a Significant Partial effect on Nurse Performance, Work Stress has a Significant Partial effect on Nurse Performance, and Burnout has a Significant negative Partial effect on Nurse Performance. Besides the variable Organizational Commitment has the most significant influence on the performance of nurses at the Siti Khodijah Muhammadiyah Hospital Sepanjang branch - Sidoarjo.
Turbid of Water By Using Fuzzy C- Means and Hard K- Means
Authors: Fawzi Rand Muhaned , Alkanani Iden Hassan 
Published: September 2020

In this research two algorithms are applied, the first is Fuzzy C Means (FCM) algorithm and the second is hard K means (HKM) algorithm to know which of them is better than the others these two algorithms are applied on a set of data collected from the Ministry of Planning on the water turbidity of five areas in Baghdad to know which of these areas are less turbid in clear water to see which months during the year are less turbid in clear water in the specified area.
Using geo-spatial analysis for assessing the Risk of Hospital Admissions due to Community-Acquired Pneumonia in Children and its association with socially vulnerable areas (Brazil)
Authors: Pina Juliana Coelho , Alves Luana Seles , Arroyo Luiz Henrique , Arcêncio Ricardo Arcêncio , Gondim Ellen Cristina , Furtado Maria Cândida de Carvalho , de Mello Débora Falleiros 
Published: September 2020

Abstract
Background: The concentration of child morbidity and mortality due to pneumonia in developing countries reflects the social inequities, which lead to greater exposure to risk factors and make access to prevention, diagnosis and treatment of the disease more difficult. This study aimed to map and assess the spatial risk for hospitalization due to Community-Acquired Pneumonia in children under 5 years of age and its association with vulnerable areas. Methods: Ecological study, carried out in the city of Ribeirão Preto, state of São Paulo, Brazil. The study population consisted of hospitalized children under the age of five, diagnosed with community-acquired pneumonia, in Ribeirão Preto-São Paulo-Brazil, from 2012 to 2013. Data were collected in different databases, by a trained team, between March 2012 and August 2013 and from the 2010 Demographic Census of the Brazilian Institute of Geography and Statistics. The 956 urban census tracts were considered as the units of analysis. The incidence of cases per 10,000 inhabitants was calculated by census tracts during the study period. For the identification of the spatial risk clusters, the Kernel density estimator and the Getis-Ord Gi* technique were measured from the Radius of the distance of 7,589km, with p<.01, found using the Incremental Spatial Autocorrelation tool. Generalized additive models were used to verify the association between areas with social vulnerability and the occurrence of childhood pneumonia. Results: The study included 265 children under the age of five, hospitalized due to community-acquired pneumonia. A concentration of cases was identified in the regions with greater social vulnerability (low income, poor housing conditions and homelessness), as well as a lower occurrence of cases in the most developed and economically privileged area of the city. The majority of the children lived in territories served by traditional primary healthcare units, in which the health surveillance and family and community focus are limited. Conclusions: The results contribute to the comprehension of the social factors involved in child hospitalization due to pneumonia, based on the analysis of the spatial distribution, and address the interface with individual and institutional factors.
MiR-103a-3p promotes tumour glycolysis in colorectal cancer&nbsp;via Hippo/YAP1/HIF1A axis
Authors: Sun Zhenqiang , Zhang Qiuge , Yuan Weitang , Li Xiaoli , Chen Chen , Guo Yaxin , Shao Bo , Dang Qin , Zhou Quanbo , Wang Qisan , Wang Guixian , Liu Jinbo , Kan Quancheng 
Published: September 2020

Abstract
Background: Glycolysis plays an essential role in the growth and metastasis of solid cancer and has received increasing attention in recent years. However, the complex regulatory mechanisms of tumour glycolysis remain elusive. This study aimed to explore the molecular effect and mechanism of the noncoding RNA miR-103a-3p on glycolysis in colorectal cancer (CRC).Methods: We explored the effects of miR-103a-3p on glycolysis and the biological functions of CRC cells in vitro and in vivo. Furthermore, we investigated whether miR-103a-3p regulates HIF1A expression through the Hippo/YAP1 pathway, and evaluated the role of the miR-103a-3p-LATS2/SAV1-YAP1-HIF1A axis in promoting glycolysis and angiogenesis in CRC cells and contributed to invasion and metastasis of CRC cells.Results: We found that miR-103a-3p was highly expressed in CRC tissues and cell lines compared with matched controls and the high expression of miR-103a-3p was associated with poor patient prognosis. Under hypoxic conditions, a high level of miR-103a-3p promoted the proliferation, invasion, migration, angiogenesis and glycolysis of CRC cells. Moreover, miR-103a-3p knockdown inhibited the growth, proliferation, and glycolysis of CRC cells and promoted the Hippo-YAP1 signalling pathway in nude mice in a xenograft model. Here, we demonstrated that miR-103a-3p could directly target LATS2 and SAV1. Subsequently, we verified that TEAD1, a transcriptional coactivator of Yes-associated protein 1 (YAP1), directly bound to the HIF1A promoter region and the YAP1 and TEAD1 proteins co-regulated the expression of HIF1A, thus promoting tumour glycolysis.Conclusions: MiR-103a-3p, which is highly expressed in CRC cells, promotes HIF1A expression by targeting the core molecules LATS2 and SAV1 of the Hippo/YAP1 pathway, contributing to enhanced proliferation, invasion, migration, glycolysis and angiogenesis in CRC. Our study revealed the functional mechanisms of miR-103a-3p/YAP1/HIF1A axis in CRC glycolysis, which would provide potential intervention targets for molecular targeted therapy of CRC.
Pseudomonas putida as a potential biocontrol agent against Salmonella Java biofilm formation in the drinking water system of broiler houses
Authors: Maes Sharon , De Reu Koen , Weyenberg Stephanie Van , Lories Bram , Heyndrickx Marc , Steenackers Hans 
Published: September 2020

Abstract
Background: Environmental biofilms can induce attachment and protection of other microorganisms including pathogens, but can also prevent them from invasion and colonization. This opens the possibility for so-called biocontrol strategies, wherein microorganisms are applied to control the presence of other microbes. The potential for both positive and negative interactions between microbes, however, raises the need for in depth characterization of the sociobiology of candidate biocontrol agents (BCAs). The inside of the drinking water system (DWS) of broiler houses is an interesting niche to apply BCAs, because contamination of these systems with pathogens plays an important role in the infection of broiler chickens and consequently humans. In this study, Pseudomonas putida, which is part of the natural microbiota in the DWS of broiler houses, was evaluated as BCA against the broiler pathogen Salmonella Java.Methods: To study the interaction between these species, an in vitro model was developed simulating biofilm formation in the drinking water system of broilers. Mono- and dual-species biofilms were grown in 6-well microtiter plates and quantified based on bacterial counts and social interactions in mixed communities were determined by the cooperation criterion and biodiversity effect.Results: Dual-species biofilms of P. putida strains P1, P2, and P3 with S. Java were characterized by competitive interactions, independent of P. putida strain, S. Java inoculum density and application order. When equal inocula of S. Java and P. putida strains P1 or P3 were simultaneously applied, the interaction was characterized by mutual inhibition, whereas P. putida strain P2 showed an exploitation of S. Java. Lowering the inoculum density of S. Java changed the interaction with P. putida strain P3 also into an exploitation of S. Java. A further increase in S. Java inhibition was established by P. putida strain P3 forming a mature biofilm before applying S. Java.Conclusions: This study provides the first results showing the potential of P. putida as BCA against S. Java in the broiler environment. Future work should include more complex microbial communities residing in the DWS, additional Salmonella strains as well as chemicals typically used to clean and disinfect the system.
Citations and publication rate of preprints on pharmacological interventions for COVID-19: The good, the bad and, the ugly.
Authors: Nicolalde Bryan , Añazco Diego , Mushtaq Mariam , Espinosa Isabel , Gimenez Jimena , Teran Enrique 
Published: September 2020

Abstract
Background: Preprints are preliminary reports that have not been peer-reviewed. On December 2019, a novel coronavirus appeared in China, and since then, scientific production, including preprints, has drastically increased. In this study, we intend to evaluate how often preprints regarding pharmacological interventions against COVID-19 were cited, in spite of the fact that some of these preprints remained unpublished.Methods: We conducted a search on medRxiv and bioRxiv to identify preprints related to pharmacological interventions against SARS-CoV-2 from January 1, 2020 to March 31, 2020. We included any study type that addressed or reported data on pharmacological interventions. We gathered metadata on June 26, 2020 of included preprints and identified if they had been published in a scholarly journal. We performed Mann-Whitney U tests to evaluate if published articles had differences in citation counts or metrics, as defined by PDF downloads and abstract reads, when compared to unpublished preprints.Results: Our sample included 97 preprints, of which 23 were published on scholarly journals and 74 remained unpublished (Publication rate of 23,7%). The most common study designs we found among preprints were basic science research and case series. The number of citations in our sample ranged from 0 to 1409 for published articles, and ranged from 0 to 175 citations for unpublished preprints. Published articles had a significantly higher number of citations when compared to unpublished preprints (p=0,000013). We did not find a statistical difference in PDF download (p=0,167) and abstract reads (p= 0,181). In the published articles, the time from posting on a preprint server to publication on a journal ranged from 0 to 98 days (median: 42.0 days). The time period from date of submission to a journal to date of acceptance in our sample ranged from 1 to 228 days (median: 23 days). Almost half of the preprints that were subsequently published (47,8%) had modifications made to the result section after peer-review.Conclusions: The publication rate of the preprints in this sample was low (1 in 4), although review times in scholarly journals seems to be accelerated. However, there was no difference in the number of views or downloads between preprints already published in scholarly journals and those not yet.
TREM-1 Associated Macrophage Polarization Plays a Significant Role in Inducing Insulin Resistance in the Obese Population
Authors: Subramanian Saravanan , Agrawal Swati , Pallati Pradeep K , Sharma Poonam , Agrawal Devendra K , Nandipati Kalyana C 
Published: September 2020

Abstract
Background: TREM-1 acts as an amplifier of inflammation expressed on macrophages. The objective of this study was to evaluate the relationship between TREM-1 and macrophage polarization, and association of TREM-1 and M1 macrophage polarization with insulin resistance (IR) in the obese population compared to the non-obese population.Methods: We enrolled 34 patients after obtaining IRB approval for this study. We evaluated the mRNA and protein expression levels of general macrophage marker (CD68), M1 marker (CD86, CCR7, iNOS, IFNγ, TNF-α, and IL-6,), M2 marker (CD206, CD163, IL-10, IL-4) and chemokine axis (MCP-1, CCR2, and CCR5) along with TREM-1 and TREM-2 in omentum fat, subcutaneous fat, and liver biopsy tissues of non-obese (N=4), obese non-diabetics, (N=16) and obese diabetics (N=14).Results: The results of our study showed over-expression of TREM-1, M1 markers, and down-regulation of TREM-2 and M2 markers in the omentum, subcutaneous and liver biopsies of obese patients (diabetics and non-diabetics) compared to non-obese patients. Overall, the obese diabetic group showed a significant (p<0.05) higher number of patients with overexpression of M1 markers (TREM-1, CD68, CD86, CCR-7, iNOS, IFN-γ, TNF-α, IL-6, MCP-1, CCR-2, and CCR-5) and down-regulation of M2 markers (CD206, CD163, IL-10, and IL-4) in liver biopsy compared to obese non-diabetics. Conclusion: TREM-1 expression is significantly increased along with the M1 markers in liver biopsy of obese diabetic (14/14) and obese nondiabetic patients (9/16). Our data suggest that TREM-1 overexpression and M1 macrophage polarization are associated with obesity-induced IR.