bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis
Authors: Huang Tao , Zhang Jun , Ke Wujian , Zhang Xiaohui , Chen Wentao , Yang Jieyi , Liao Yiwen , Liang Fangwen , Mei Shuqing , Li Mingjiu , Luo Zhenzhou , Zhang Qiwei , Yang Bin , Zheng Heping 
Published: January 2020

Abstract
Background
Treponema pallidum ( T. pallidum ) infection evokes significant immune responses, resulting in tissue damage. The immune mechanism underlying T. pallidum infection is still unclear, although microRNAs (miRNAs) have been shown to influence immune cell function and, consequently, the generation of antibody responses during other microbe infections. However, these mechanisms are unknown for T. pallidum .
Methods
In this study, we performed a comprehensive analysis of differentially expressed miRNAs in healthy individuals, untreated patients with syphilis, patients in the serofast state, and serologically cured patients. miRNAs were profiled from the peripheral blood of patients obtained at the time of serological diagnosis. Then, both the target sequence analysis of these different miRNAs and pathway analysis were performed to identify important immune and cell signaling pathways. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was performed for microRNA analysis.
Results
A total of 89 differentially regulated miRNAs were identified. Following RT-qPCR confirmation, three miRNAs (hsa-miR-195-5p, hsa-miR-223-3p, hsa-miR-589-3p) showed significant differences in the serofast and serologically cured states ( P <0.05). One miRNA (hsa-miR-195-5p) showed significant differences between untreated patients and healthy individuals.
Conclusions
This is the first study of miRNA expression differences in peripheral blood mononuclear cells (PBMCs) in different stages of T. pallium infection. Our study suggests that the combination of three miRNAs has great potential to serve as a non-invasive biomarker of T. pallium infections, which will facilitate better diagnosis and treatment of T. pallium infections.
Visual Style of 21 Intelectual Property Right (IPR) Certified Lasem Batik Motifs as the Expression of Cultural Hybridity
Authors: Setyoningrum Yunita , Lukman Christine Claudia , Rismantojo Sandy 
Published: January 2020

The problem in this research derived from the fact that many Lasem batik entrepreneurs nowadays had limited knowledge of the novel characteristics of Lasem batik and hardly aware of its geographical indication. The research objective was to identify how the cultural hybridity of Chinese-Javanese culture and Lasem geographical environment were reflected by both the Tionghoa Peranakan-descent and Javanese-descent artists through the visual signs in the batik design. The purposive samples used were 21 Lasem batik motifs made by Tionghoa Peranakan-descent and Javanese-descent entrepreneurs which already IPR-certified. The method used was a compositional interpretation by interpreting each batik motif composition according to its content (subject matter), color, spatial organization, and expressive content (the combined effect of subject matter and visual form). The finding reveals that Lasem visual style hybridity is generally visible in: (1) the use of Chinese subject matter combined with Javanese motifs, (2) the use of Chinese subject matter combined with local Javanese isen-isen (texture), and (3) the rich use of red (from Chinese batik visual style) combined with brown (from Javanese batik visual style). This finding can be used as a reference guide for latter Lasem batik entrepreneurs to maintain the particular characteristics of Lasem batik while developing other batik motifs innovation.
EXPERIENCE WITH SUBCUTANEOUS TRASTUZUMAB USED IN RUSSIAN FEDERATION
Authors: Lubennikova E. V. , Ganshina I. P. , Lud A. N. , Komov D. V. , Kolyadina I. V. , Vishnevskaya Y. V. , Vorotnikov I. K. , Stroyakovsky D. L. , Savelov N. A. , Semiglazov V. F. , Manikhas А. G. , Osheychik А. V. , Strelnikova T. B. , Zeynalova K. R. , Zhukova L. G. 
Published: January 2020

The HannaH study showed that neoadjuvante-adjuvant subcutaneous and intravenous trastuzumab have similar efficacy and tolerability in patients with early HER2-positive breast cancer. The analysis of the results of the subcutaneous and intravenous trastuzumab usage in Russian population showed the favorable association between tpCR anf EFS. tpCR achiviement is associated with clinical benefit in HER2 positive breast cancer. For patients with difficult venous access who do not require intravenous chemotherapy currently, Subcutaneous trastuzumab allows to receive effective treatment without the risk of complications, which involves catheterization of a Central vein.
TRENDS OF INITIAL METABOLIC SYNDROME AND ITS RELATIONSHIP WITH SUBCLINICAL ATHEROSCLEROSIS AMONG YOUNG AND MIDDLE-AGED MEN
Authors: Serdyukov D. Y. , Gordienko A. V. , Dyidyishko V. T. , Panova M. A. , Rudchenko I. V. 
Published: January 2020

Atherosclerotic cardiovascular diseases substantially have contributing to mortality and structure of disability in developed countries. Metabolic syndrome is a cluster of clinico-biochemical changes with the most aterogenic potential.Objective: to determine trends of early stages of metabolic syndrome and its relationship with the initial atherosclerosis in young and middle-aged men. Have been examined 436 men with an assessment symptoms of metabolic syndrome, as well as signs of subclinical atherosclerosis. The young men with initial manifestations of metabolic syndrome were characterized by the classical cardiovascular risk factors. According to the results of the study have been already diagnosed dyslipidemia, violation of apolipoproteides fractions, postprandial hyperglycemia at the initial stage of metabolic syndrome in this category of patients. have been proposed assessment of waist circumference, degree of diastolic blood pressure and postprandial glycemia as the most sensitive diagnostic markers of cardiovascular lesions in primary manifestations of metabolic syndrome.
PROSPECTS OF NEPHROPROTECTION AGAINST TYPE 2 DIABETES USING THE DPP-4 INHIBITOR VILDAGLIPTIN
Authors: Bayrasheva V. K. , Babenko A. Y. , Bayramov A. A. , Chefu S. G. , Shatalov I. S. , Pchelin I. Y. , Arefieva A. N. , Grineva E. N. 
Published: January 2020

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus (DM), which increases morbidity and mortality. Accumulated evidence, mostly experimental ones that DPP-4 inhibitors have non-glycemic tissue effects including renal protection. Clinical data confirming these effects are insufficient. This makes it relevant to study the influence of iDPP-4 on the renal function in patients with Type 2 diabetes.To study the effects of iDPP vildagliptin on glycemic, metabolic and renal parameters in patients with type 2 diabetes with CKD 1–2 receiving insulin therapy 44 patients were randomized to continue therapy with insulin or insulin + vildagliptin at a dose of 50 mg/day, with the evaluation of results in 6 months.In group of vildagliptin therapy a significant decrease of HbA1c, postprandial glycemia, diastolic blood pressure, HOMA-IR, insulin demand and a reduction in the frequency of hypoglycemia occurred. The positive dynamics of indicators of glomerular functions of the kidney were noted in this group - a significant reduction in albuminuria and a significant increase in eGFR by cystatin C and decreased urinary excretion of type IV collagen. The findings suggest the positive effect of vildagliptin on metabolic status and indicators of glycaemia and hemodynamics as earlier confirmed in clinical studies and the ability of vildagliptin independent from glycemic effects to slow the development of glomerular dysfunction in patients with type 2 diabetes and the initial manifestations of DN.
Treatment of Bisphenol A (BPA) in water using UV/H2O2 and reverse osmosis (RO) membranes: assessment of estrogenic activity and membrane adsorption
Authors: Moreira Carolina G. , Moreira Mariana H. , Silva Vanessa M. O. C. , Santos Henrique G. , Bila Daniele M. , Fonseca Fabiana V. 
Published: January 2020

Abstract
Removal of an endocrine disrupting compound, Bisphenol A (BPA), from water was investigated using two treatment processes, UV/H2O2 advanced oxidation (AOP) and reverse osmosis (membrane separation). Furthermore, changes in estrogenic activity using in vitro yeast estrogen screen assay as well as the adsorption of BPA by the membrane surface were evaluated. The best UV/H2O2 performance was obtained using the highest established values of all parameters, reaching 48% BPA removal. Within the investigated conditions of the AOP, when lower doses of UV were used, a higher removal efficiency was achieved at a higher initial concentration of BPA. However, the same behavior was not observed for the highest UV dose, in which the removal efficiency was not dependent on BPA initial concentration. In both cases, removal efficiency increased as H2O2 concentration increased. The formation of estrogenic by-products was observed in UV/H2O2. The membrane rejection efficiency varied from 60% to 84% and all experiments showed adsorption of BPA by the membrane surface. The RO membrane showed a greater BPA removal efficiency for samples containing 10 μg·L−1 than UV/H2O2 at the evaluated treatment conditions.
Percepção da corrupção em ambiente acadêmico: análise empírica a partir de alunos do curso de ciências contábeis da Universidade Federal do Ceará (UFC)
Authors: Do Nascimento Roberto Sérgio , Pinho Ruth Carvalho de Santana 
Published: January 2020

Objetivo: A corrupção é um fenômeno mundial que atinge, indistintamente, pobres e ricos. Como fenômeno multidisciplinar, compreender o problema tornou-se um aspecto complexo dado à diversidade de conceitos que abarca e a forma como se apresenta nos países. Neste sentido, o presente trabalho objetiva analisar aspectos significativos do perfil social que influenciam a percepção da corrupção por parte dos alunos de Ciências Contábeis da Universidade Federal do Ceará.
Metodologia: A pesquisa se caracteriza como descritiva quanto aos objetivos, de levantamento quanto aos procedimentos e quantitativa quanto à natureza. Utilizou-se questionário com escala do tipo Likert, preenchido de forma anônima, formado por 4 grupos de perguntas, nos quais se alocou 20 questões associadas ao tema corrupção (compreensão, impacto profissional, estrutura atual do curso de ciências contábeis e mecanismos institucionais para o seu combate). A análise dos resultados se deu por intermédio da estatística descritiva.
Resultados: Foram considerados posicionamentos intermediários que não revelam a total negação ou confirmação das perguntas apresentadas, o que evidencia que parte das opiniões ainda se encontra em construção. A exceção se deve ao nível de compreensão do fenômeno que foi considerado satisfatório pelos pesquisadores. No que se refere às respostas intermediárias, os resultados apontam para a necessidade de múltiplas soluções em relação ao fenômeno estudado: aprimoramento do tratamento do tema por parte do curso como um todo, melhora da compreensão da amplitude da corrupção como fenômeno que atinge também empresas e organizações sociais e afastamento do entendimento dos alunos de que o curso deve prover conhecimento acerca do modus operandi dos atos corruptos.
Contribuições do Estudo: O estudo contribui para que novas formas de abordagem da corrupção sejam desenvolvidas para o ambiente acadêmico, notadamente do Curso de Ciências Contábeis, visando aumentar a percepção sobre o tema.
Provável, possível ou remoto? Um estudo acerca das contingências tributárias dos bancos brasileiros
Authors: Schmitt Matheus , Fagundes Ernando , Alex Mussoi Ribeiro  
Published: January 2020

Objetivo: Identificar fatores determinantes na classificação das provisões e passivos contingentes tributários pelas instituições financeiras brasileiras. A natureza tributária foi escolhida devido a representatividade destas contingências. Já as instituições financeiras foram elencadas pela escassez de pesquisas similares.
Metodologia: Para analisar os fatores determinantes da classificação provisões e contingências foi utilizado um modelo de regressão logística. As empresas analisadas pertencem a Brasil, Bolsa, Balcão (B3) e o período analisado compreende o exercício de 2016.
Resultados: A média dos processos em que as instituições financeiras são rés apresentam 5 anos de instauração e o valor relativo dos processos (razão entre montante do processo e ativo da empresa) representa em média 0,4%. Os resultados do estudo corroboram a Ribeiro (2012), uma vez que existe divergência de opiniões na interpretação da legislação e na determinação da chance de perda, sendo uma prática factível de gerenciamento de resultados. Corrobora com Hennes (2014), visto que observou a insuficiência das divulgações quantitativas para determinar as expectativas de perda e com Aharony e Dotan (2004) que demonstraram o menor conservadorismo dos gestores e auditores quando comparados aos analistas financeiros. Alinhando aos estudos similares e a Teoria Positiva da Contabilidade, conclui-se que a discricionariedade fornecida aos gestores pode contribuir no gerenciamento de informações, possibilitando o uso desta com intuito informativo ou oportunista.
Contribuições do Estudo: A contribuição deste estudo está em elucidar questões relacionadas aos elementos que direcionam os critérios de classificação das provisões e dos passivos contingentes utilizados pelos gestores. Assim, contribui evidenciando como características relacionadas com os processos (esfera administrativa ou judicial), a instância, o seu valor e seu prazo de condução podem influenciar na classificação como provável, possível ou remoto.
Método do caso: um relato sobre sua efetividade e aplicabilidade no ensino de contabilidade
Authors: Januário Alessandro Henrique de Araújo , Pinho Cássia Marcelle Dias , Gonçalves Tadeu Junior de Castro , Araújo Aneide Oliveira 
Published: January 2020

Objetivo: Investigar a efetividade e a aplicabilidade do método do caso junto a alunos do mestrado em ciências contábeis da Universidade Federal do Rio Grande do Norte (UFRN).
Metodologia: O estudo realizado foi caracterizado como descritivo e a coleta de dados se deu através de um questionário com perguntas abertas após a aplicação de um caso. O tratamento dos dados foi realizado através de análise de conteúdo com auxílio do software ATLAS.ti®.
Resultados: No que diz respeito à efetividade, destacou-se a interação dos alunos a partir das discussões em pequenos grupos para, posteriormente, no grande grupo, ocorrer a contribuição para a resolução do caso com uma discussão mais profunda. Referente à aplicabilidade, os resultados demonstram a necessidade de utilização de outras metodologias ativas na resolução do caso, como exemplo mais citado pelos alunos, têm-se o role-play. Também foram evidenciadas as dificuldades e limitações identificadas durante a intervenção educativa, entre elas, o pouco tempo disponibilizado para a aplicação deste método e a dificuldade de se encontrar bons casos para aplicar em sala de aula.
Contribuições do estudo: O estudo contribui com as discussões acerca da adoção de metodologias ativas, o que permite a identificação de pontos fortes e fracos, assim como as limitações, oportunizando, por consequência, sugestões de melhoria e aprimoramento do processo de ensino-aprendizagem.
CRESCIMENTO POPULACIONAL, PAISAGEM E QUALIDADE DE VIDA EM POÇOS DE CALDAS (MG), UMA CIDADE MÉDIA TURÍSTICA
Authors: Carvalho de Andrade Alexandre , Moraes Ramos Giovanna , Miranda Martins Raphael 
Published: January 2020

Poços de Caldas é um município localizado no Sul de Minas e tem população de 152.435 habitantes (IBGE, 2010). Desde o começo de sua formação como cidade, apresenta significativa importância da atividade turística, em especial devido as fontes de águas hidrotermais e sua paisagem montanhosa. Entretanto, em meados do século XX se iniciou um processo de diversificação e desenvolvimento da economia, o que favoreceu o crescimento populacional, a expansão urbana, e, por consequência, aconteceram diferentes impactos na qualidade de vida, na organização espacial e na paisagem local. Neste contexto, o presente trabalho tem como objetivo analisar a qualidade de vida em Poços de Caldas, por meio de indicadores quantitativos e da percepção de seus moradores.
Palavras-chave: Qualidade de Vida Urbana; Paisagens; Turismo.
Inhibition of Cyclooxygenase Enzyme by Bioflavonoids in Horsegram Seeds Alleviates Pain and Inflammation
Authors: Ramalingam Malarvizhi , Sali Veeresh K. , Bhardwaj Meenakshi , Mani Sugumar , Vasanthi Hannah R. 
Published: January 2020

Background:
Inflammation and pain, mainly induced by the prostaglandins synthesized
by the cyclooxygenase enzymes, may cause distress. To overcome this unpleasant stress in a safer
manner, numerous natural molecules are proven for modulating the COX enzymes. Epicatechin
and daidzein are two bioactive natural compounds present in horsegram, a legume known for its
medicinal properties.

Objective:
The present study aims at evaluating the potential of horsegram, and some of its
bioactive molecules, to be used as an anti-inflammatory and analgesic agent mediated by the
inhibition of COX enzymes, which can be recommended as a substitute for chemically synthesized
NSAIDs.

Methods:
The present work involved the quantification of epicatechin and daidzein present in
horsegram seeds. The COX enzyme inhibitory nature of epicatechin and daidzein was tested using
in silico docking analysis with Autodock software and was further confirmed by in vitro COX
inhibitory biochemical assays. Furthermore, the anti-inflammatory and analgesic activities of the
horsegram seeds were evaluated in animal experiments.

Results:
Horsegram seeds contain 158.1 microgram/g and 6.51 microgram/g of epicatechin and
daidzein respectively. The docking studies reveal that both the bioactive molecules exhibit better
binding efficiency with COX-2 protein as compared to COX-1. Hence, in vitro COX-2 inhibitory
assay was performed for epicatechin, daidzein and compared with known analgesic agent
diclofenac which revealed a pronounced dose dependent inhibitory activity. Furthermore, the
analgesic and anti-inflammatory activity of horsegram in experimental animals exhibited a dose
dependent effect which might be due to the presence of the bioactive compounds such as
epicatechin and daidzein.

Conclusion:
The results suggest that epicatechin and daidzein present in horsegram are potent
cyclooxygenase inhibitors and thus would be helpful in the management of inflammation and pain.
Combinatorial Synthesis of A Series of Paeonol-based Phenylsulfonyl hydrazone Derivatives as Insecticidal Agents
Authors: Che Zhi-Ping , Yang Jin-Ming , Sun Di , Tian Yue-E , Liu Sheng-Ming , Lin Xiao-Min , Jiang Jia , Chen Gen-Qiang 
Published: January 2020

Background:
Plant secondary metabolites play an essential role in the discovery of
novel insecticide due to their unique sources and potential target sites. Paeonol, the main phenolic
components in Moutan Cortex, is recognized as a safe and potent botanical insecticide to many
insects. The structural modification of paeonol in this study into phenylsulfonylhydrazone
derivatives is proved an effective approach for the development of novel insecticides, those
derivatives being more toxic than paeonol. However, there have been no reports on the insecticidal
activity of paeonol-based phenylsulfonylhydrazone derivatives in controlling Mythimna separata.

Methods:
We have been working to discover biorational natural products-based insecticides.
Twelve novel paeonol-based phenylsulfonylhydrazone derivatives have been successfully prepared
by structural modification of paeonol, and the insecticidal activity against M. separata by the leafdipping
method at the concentration of 1 mg/mL has been evaluated.

Results:
Insecticidal activity revealed that out of 12 title compounds, derivatives 5c and 5f
displayed the best against M. separate with the FMR both of 53.6% than toosendanin (FMR =
50.0%).

Conclusion:
The results suggested that for the paeonol-based phenylsulfonylhydrazone series
derivatives, the proper substituent of arylsulfonyl R at the hydroxyl position of paeonol was very
important for their insecticidal activity. These preliminary results will pave the way for further
modification of paeonol in the development of potential new insecticides.
Formulation, Standardization, and a Preliminary Before-After Clinical Trial on Effect of a Traditional Herbal Formula (Maqliasa) on Manifestations of Ulcerative Colitis
Authors: Shirzad Meysam , Ahmadian-Attari Mohammad Mahdi , Ghafoori Seyed Mohammad Sadegh , Kashani Leila Mohammad Taghizadeh , Pasalar Mehdi , Abbassian Alireza , Agah Shahram 
Published: January 2020

Background:
Ulcerative Colitis (UC) is a chronic condition that represents a group of
intestinal disorders causing prolonged inflammation of the digestive tract. Nowadays, efforts to
investigate new remedies have led to a committed movement toward the integration of traditional
and complementary medicine into mainstream medicine. In Traditional Persian Medicine (TPM),
Maqliasa is one of the most frequent gastrointestinal prescriptions which is claimed to be effective
in both remission and recurrent phases of UC.

Objective:
The aim of this pilot study was to examine the effect of Maqliasa on UC symptoms.

Methods:
Through a non-randomized before-after uncontrolled clinical trial, 13 outpatients with
active UC were enrolled in the study. They continued their conventional drug regimens plus
Maqliasa capsules (2 capsules t.i.d.) for 28 days. Three visits were arranged for each patient− the
first admission, day 14th admission and day 28th admission. The patients were evaluated by
Lichtiger Colitis Activity Index. Wilcoxon signed-rank test was used for statistical analysis.

Results:
The Lichtiger colitis activity index improved in the study group was compared to the corresponding
baseline values: baseline score: 7.8 ± 0.5; after two weeks: 5.9 ± 0.6 (P=0.002); after
four weeks: 3.6 ± 0.5 (P=0.001).

Conclusion:
This study showed the promising effect of Maqliasa in the treatment of active UC.
However, due to some of the limitations of the study, conducting future high-quality randomized
clinical trials would be crucial.
Utilization of LTEx Feynman Gate in Designing the QCA Based Reversible Binary to Gray and Gray to Binary Code Converters
Authors: Mukherjee Chiradeep , Panda Saradindu , Mukhopadhyay Asish K. , Maji Bansibadan 
Published: January 2020

Aims:
The Quantum-dot Cellular Automata explores a unique perspective in the arena of
the architectural design of future quantum computers, precisely due to its ultra-low packing density,
high operating speed, and low power dissipation. On the other side, reversible computing allows the
implementation of extreme low power-consuming circuits by avoiding energy dissipation during the
time of computation.

Objective:
In this paper, we have explored the QCA design of reversible binary to gray and gray to binary
code converters based on the application of a unique model of Feynman gate using the layered T
exclusive-OR module (abbreviated in this work as LTEx Feynman gate).

Methods:
We have proposed algorithms to produce multi-control reversible binary to gray and gray to
binary code converters and to develop cost-efficient QCA layouts.

Results:
Our systematic literature survey on the existing QCA designs of reversible binary to gray and
gray to binary code converters helped us to compare and analyze the proposed design with the existing
ones and identify it as the best design in terms of reversible, and QCA design metrics.

Conclusion:
Significant improvements in design metrics owing to successful experimentations over
the previous designs are reported while instantiating 3X3,4X4, and 8X8 counterpart layouts.