bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENYALAHGUNAAN NARKOBA PADA ANAK -ANAK DIBAHAH UMUR DAN PENANGGULANGANNYA
Authors: Amelia Fitri Rezki 
Published: June 2020

Maraknya penyalahgunaan barang haram (narkoba) akhir-akhir ini menjadi isu yang sangat mengkhawatirkan di Indonesia. Dari fakta yang dapat disaksikan hampir setiap hari baik melalui media cetak maupun elektronik, barang haram tersebut telah merebak kemana-mana tanpa pandang bulu, terutama di antara remaja yang sangat diharapkan menjadi generasi penerus bangsa dalam membangun negara di masa mendatang. Narkoba (narkotika, psikotropika dan bahan-bahan zat adiktif lainnya) dapat membahayakan kehidupan manusia, jika dikonsumsi dengan cara yang tidak tepat, bahkan dapat menyebabkan kematian. Narkoba mempunyai dampak negatif yang sangat luas; baik secara fisik, psikis, ekonomi, sosial budaya hankam, dan lain sebagainya. Banyak cara digunakan agar pemakai narkoba dapat normal dan pulih kembali seperti biasanya.Sehingga kepada pemakai / pengedar dalam ketentuan hukum pidana nasional diberikan sanksi yang berat. Metode penelitian adalah studi kepustakaan, hasilnya adalah kasus penyalahgunaan narkoba mengalami peningkatan sangat tajam karena belum ada standarisasi sistem pencatatan dan pelaporan penyalahgunaan narkoba.
ANALISIS SEMIOTIKA JULIA KRISTEVA DALAM FILM “SEXY KILLERS” (Pendekatan Semanalisis Hingga Intertekstualitas
Authors: Abdullah Siti Nur Alfia 
Published: June 2020

Munculnya sebuah film yang menceritakan keadaan bangsa Indonesia yang melibatkan petinggi-petinggi bangsa dan masyarakatnya yang mempunyai pemahaman berbeda dalam melihat sebuah teknologi, menjadi suatu hal yang patut untuk ditelaah kembali, sejak film tersebut muncul, telah menuai berbagai pujian dan pula yang mengkritisi serta memaknainya dengan cara yang berbeda , yakni film “Sexy Killers. Ini menjadi sebuah dasar penulis dalam melakukan penelitian untuk melihat perbedaan tersebut dari berbagai macam bentuk pemaknaan yang dibangun, dengan memaki teori semiotika dari Julia Kristeva, tentang semanalisis hingga intertektualitas. Walaupun teori tersebut terfokus pada bahasa puitis, namun penulis ingin mencoba menerapkannya dalam sebuah media film yang jarang dilakukan dalam peneltian lain. Hasil penelitian menjelaskan bahwa makna tidaklah mesti dipahami secara kaku dan otoriter, namun makna memiliki perkembangan yang terus berinovasi, “sexy killers” dalam perwujudannya merupakan teks full yang tidak bisa dirubah dalam kristeva disebut dengan genoteksnya, fenoteks merupakan makna yang berkembang di tengah masyarakat saat menyaksikan “sexy killers” makna yang dihasillkan pun berbeda beda, bisa jadi makna tersebut dipahami sama dengan tujuan dari si sutradara film sendiri sebagai bentuk kritis terhadap pemerintah yang tidak bijak dalam melakukan pembangunan tambang batu bara, atau bahkan proses hadirnya film tersebut dimaknai sebatas informasi sesaat dan tidak memiliki pengaruh apa-apa.
Low Potential Pitting Corrosion of Ni-Cr-Fe Alloys in Chloride Plus Thiosulfate Solutions: Determination of Potential and Concentration Boundaries
Authors: Becerra Araneda Abraham A. , Kappes Mariano A. , Rodríguez Martín A. , Carranza Ricardo M. 
Published: June 2020

Low potential pitting corrosion (LPPC) of Alloys 690 and 800 (UNS N06690 and N08800) was studied in neutral solutions, containing chloride ions from 0.1 M to 1 M and thiosulfate ions from 5 × 10−5 M to 10−3 M. LPPC occurred close to the corrosion potential (–0.25 VAg/AgCl) by a synergic effect of the chloride and thiosulfate ions. The threshold concentrations of aggressive species for LPPC occurrence were identified by potentiostatic tests with mechanical scratching of the surface, which yielded more conservative estimations compared to other electrochemical tests. The ranges of potential and concentration of chloride and thiosulfate where LPPC occurred and where it merged with the conventional chloride pitting were determined. The lowest threshold concentrations were measured in Alloy 800, with a lower Cr content than Alloy 690. Thermally-aged Alloys 800 and 690 had lower resistance to LPPC than the corresponding solution-annealed material. In 1 M chloride-based solutions, for aged Alloy 800, LPPC occurred at a thiosulfate concentration as low as 5 × 10−5 M; in 10−3 M thiosulfate-based solutions, the chloride threshold was 0.1 M. For thermally-aged alloys, pits propagated intergranulary in some experiments. In solutions with chloride and thiosulfate concentrations close to the threshold required for pitting, repassivation of LPPC was observed after a sustained period of pit growth, originally initiated by scratching the surface. Such a repassivation has not been reported before in the literature in chloride and thiosulfate solutions. Two possible explanations were presented for this phenomenon.
Gait disturbances in patients with rheumatoid arthritis
Authors: Dzięcioł-Anikiej Zofia , Kuryliszyn-Moskal Anna , Hryniewicz Anna , Kaniewska Katarzyna , Chilińska-Kopko Ewelina , Dzięcioł Janusz 
Published: June 2020

IntroductionRheumatoid arthritis (RA) is a chronic inflammation resulting in the involvement of all the structures constituting a joint. We determined the type and severity of foot deformities, determined the impact of the degree of disturbances of foot statics and the disease activity on the duration of the particular phases of gait, determined the impact of the maximum foot load and the percentage distribution of loads between the forefoot and hindfoot on the duration of the particular phases of gait, and established the link between observed disorders and the stage of rheumatoid arthritis.Material and methodsThe control group consisted of 41 healthy women. Rheumatoid arthritis patients, whose disease had been diagnosed based on the American College of Rheumatology (ACR) criteria, were divided into three groups. Group I consisted of 56 women, Group II of 28 patients in the first and second stage of RA, Group III of 28 patients in the third and fourth stage of the disease. We calculated the disease activity score (DAS28 index) and body mass index, and we conducted a pedobarographic examination.ResultsThe results obtained in our study revealed the disturbances of the parameters of foot statics in RA patients. We also detected a prolongation of gait phases, resulting from the disturbances of statics and the displacement of the maximum foot load both in static and dynamic conditions. Increased activity of the disease constituted an additional factor affecting the prolongation of gait phases.ConclusionsOur results confirm the usefulness of baropodometric examination as an important diagnostic tool in the evaluation of the locomotor system of RA patients.
Familial Mediterranean fever association with schizophrenia: insights from big data analysis
Authors: Sharif Kassem , Watad Abdulla , Bragazzi Nicola , Yavne Yarden , Bridgewood Charlie , McGonagle Dennis , Comanhester Doron , Cohen Arnon , Amital Howard 
Published: June 2020

IntroductionSeveral autoimmune diseases have been associated with schi¬zophrenia; however, little is known about putative links with auto-inflam¬matory conditions. We investigated the association between familial Mediterranean fever (FMF), a paradigmatic auto-inflammatory disease, and schizophrenia and assessed the impact of the latter on the survival of FMF patients.Material and methodsA case-control study was performed by utilising the database of Clalit Health Services, the largest health maintenance organisation in Israel. Familial Mediterranean fever patients were compared to age- and sex-matched controls in terms of prevalence of schizophrenia. The χ2 test was used to assess the distribution of categorical variables, while the t-test was applied for continuous variables. Analysis regarding survival was performed using Kaplan-Meier curves, log rank test, and multivariate Cox proportional-hazards method. Statistical analysis was performed using SPSS version 24.0, IBM, USA.ResultsThe study included 7747 FMF patients and 10,080 age- and sex- matched controls (case-control match 1 : 1.3). On univariate analysis, 50 FMF patients (0.6%) and 89 controls (0.9%) had schizophrenia. On multiple logistic regression model, FMF was inversely associated with schizophrenia (OR = 0.64 [95% CI: 0.43–0.90], p = 0.0173). Familial Mediterranean fever (HR = 1.43 [95% CI: 1.23–1.66]) and schizophrenia (HR = 3.97 [95% CI: 1.47–10.70]) were independently associated with all-cause mortality. However, schizophrenia as a co-morbidity in FMF subjects did not worsen their prognosis (HR = 2.17 [95% CI: 0.60–7.86]).ConclusionsFamilial Mediterranean fever patients have a significantly lower proportion of schizophrenia than controls. The current evidence shows that auto-inflammatory conditions confer protection against schizophrenia development. Patients with either FMF or schizophrenia are at higher risk of all-cause mortality, a finding that calls for assessment of better medical management of mortality outcomes.
Effects of epigallocatechin gallate on total antioxidant capacity, biomarkers of systemic low-grade inflammation and metabolic risk factors in patients with type 2 diabetes mellitus: the role of FTO-rs9939609 polymorphism
Authors: Hosseini Seyedahmad , Alipour Meysam , Zakerkish Mehrnoosh , Cheraghian Bahman , Ghandil Pegah 
Published: June 2020

IntroductionType 2 diabetes mellitus (T2DM) is known as one of the most common metabolic diseases and FTO polymorphism has been implicated in the susceptibility to this disease. Epigallocatechin-3-gallate (EGCG) has shown favorable effects on risk factors related to T2DM. The present study aimed to investigate the effects of EGCG on total antioxidant capacity, biomarkers of systemic low-grade inflammation and metabolic risk factors in patients with T2DM considering the role of FTO polymorphism.Material and methodsIn this double-blind randomized clinical trial, 60 patients with T2DM (20–60 years) were randomly allocated to three groups. Group 1 received 300 mg of EGCG (TT genotype). Group 2 received 300 mg of EGCG (AA + AT genotypes) and Group 3 received placebo. We genotyped FTO (rs9939609) and measured body mass index (BMI), blood pressure, profile lipid, interleukin-6, high sensitivity C-reactive protein and total antioxidant capacity, before and after the intervention, at 2 months.ResultsIn carriers of A allele, EGCG intervention caused a significant decrease in BMI, diastolic blood pressure (DBP), mean arterial pressure and serum cholesterol level compared with placebo (p < 0.05). Also, we found a significant gene-treatment interaction effect between FTO-rs9939609 and EGCG on BMI and DBP (P > 0.05).ConclusionsThese findings suggest that carriers of the risk alleles (A) of FTO-rs9939609 have a better response to EGCG in improving BMI and DBP in patients with T2DM.
Camelliol C inhibits viability, migration, and invasion of human cervical cancer cells via induction of apoptosis, G2/M cell cycle arrest, and blocking of PI3K/AKT signalling pathway
Authors: An Na , Liu Feng 
Published: June 2020

IntroductionCervical cancer is a devastating cancer and is currently ranked as the fourth most prevalent type of cancer in the world. The lack of efficacious chemotherapy forms a bottleneck in the treatment of cervical cancer. This study was therefore undertaken to evaluate the anticancer effects of camelliol C against human cervical cancer cells.Material and methodsNormal cell line (NCEC) and cervical cancer cell lines (Csdki, HeLa, C33A, and siHa) were used in this study. Cell viability was determined by MTT assay, and apoptosis was detected by DAPI and annexin V/PI staining. Cell cycle analysis, ROS, and MMP levels were examined by flow cytometry. Cell migration and invasion was monitored by transwell assays.ResultsThe results showed that camelliol C inhibits the proliferation of all the human cervical cancer cell lines with IC<SUB>50</SUB> ranging from 10 to 20 µM. However, comparatively low antiproliferative effects were observed on the normal cells. Investigation of the underlying mechanisms showed that camelliol C induces apoptosis in HeLa cancer cells. Camelliol C-triggered apoptosis was also linked with cleavage of caspase-3 and -9, and PARP. Additionally, the Bax protein levels were increased and those of Bcl-2 were decreased. Transwell assays showed that camelliol C suppresses the migration and invasion of the HeLa cervical cancer cells. Additionally, camelliol C also blocked the PI3K/AT signalling cascade dose dependently.ConclusionsCamelliol C may prove beneficial in the treatment of cervical cancer.
Integrative analysis reveals key mRNA and long non-coding RNA interaction in idiopathic pulmonary arterial hypertension
Authors: Wang Ruomeng , Zhuang Qi , Wang Jian , Yang Menghui , Zhang Xueming , Shen Jieyan 
Published: June 2020

IntroductionIdiopathic pulmonary arterial hypertension (IPAH) is a rare and sporadic form of pulmonary arterial hypertension (PAH), characterized by elevated pulmonary arterial resistance leading to right heart failure. However, molecular mechanisms of PAH development are still not completely understood.Material and methodsIn this study, we aimed to uncover key mRNAs and long non-coding RNA (lncRNAs), functional modules and pathways. Moreover, to detect the dysregulated pathway or biological function, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. PPI and co-expression networks were constructed to reveal the potential roles of PAH-related mRNAs and lncRNAs.ResultsA total of 3,134 genes, including 945 up-regulated and 2,189 down-regulated genes, were identified to be differentially expressed in IPAH by differential expression analysis. We identified T cell differentiation and the T cell receptor signaling pathway as up-regulated in IPAH by using GO and KEGG analysis. Based on the PPI module analysis, we identified that the pro-inflammatory genes, such as OAS1, CXCL10, STAT1 and TLR4, were the hub genes in the PPI modules. To link the lncRNAs to the PPI modules, we calculated the Spearman correlation coefficient for lncRNA-DE-mRNA pairs to identify the modules with high correlation with each lncRNA.ConclusionsNotably, 6 of these lncRNAs were associated with modules characterized by the NOD-like receptor signaling pathway and chemokine signaling pathway, suggesting that these lncRNAs may promote the occurrence of IPAH via participating in the pro-inflammatory pathways. In conclusion, our systematic analysis not only improved our understanding of the molecular mechanism, but also provided potential lncRNA biomarkers for further research.
Anticancer activity of sulforaphane against human hepatoblastoma cells involves apoptosis, autophagy and inhibition of β-catenin signaling pathway
Authors: Lin Junshan , Xu Yali , Zhao Xing , Qiu Zhixin 
Published: June 2020

IntroductionSulforaphane is an active isothiocyanate and has been reported to exhibit many pharmacological and biological activities including anticancer activity. The current study was undertaken to examine its anticancer activity against human hepatoblastoma.Material and methodsMTT and clonogenic assays were used to assess the antiproliferative effects of sulforaphane. Annexin V/PI staining and immunofluorescence microscopy were used to monitor the induction of apoptosis. GFP-LC3 transfection and fluorescence microscopy were used to investigate the induction of autophagy. Cell migration and invasion were assessed through wound healing and transwell chamber assay. Protein expression was determined by western blot analysis.ResultsThe results indicated that sulforaphane induced antiproliferative effects on the hepatoblastoma cell lines and exhibited an IC50 of 10 µM against the Hepu1 and HepU2 cells as compared to the IC50 of 90 µM against the normal THLE-2 cells. The antiproliferative effects were observed to be mediated via apoptosis which was accompanied by upregulation of Bax and suppression of Bcl-2 together with activation of caspase-3 and PARP cleavage. Sulforaphane also induced autophagy and the β-catenin signaling pathway. In addition, cell migration and cell invasion of the hepatoblastoma cells were also suppressed upon sulforaphane treatment.ConclusionsThe results indicated that sulforaphane is a potential anticancer agent and may be considered as a lead molecule in the development of hepatoblastoma chemotherapy.
Northern Hemisphere blocking simulation in current climate models: evaluating progress from the Climate Model Intercomparison Project Phase 5 to 6 and sensitivity to resolution
Authors: Schiemann Reinhard , Athanasiadis Panos , Barriopedro David , Doblas-Reyes Francisco , Lohmann Katja , Roberts Malcolm J. , Sein Dmitry V. , Roberts Christopher D. , Terray Laurent , Vidale Pier Luigi 
Published: June 2020

Abstract. Global climate models (GCMs) are known to suffer from biases in the simulation of atmospheric blocking, and this study provides an assessment of how blocking is represented by the latest generation of GCMs. It is evaluated (i) how historical CMIP6 (Climate Model Intercomparison Project Phase 6) simulations perform compared to CMIP5 simulations and (ii) how horizontal model resolution affects the simulation of blocking in the CMIP6-HighResMIP (PRIMAVERA – PRocess-based climate sIMulation: AdVances in high-resolution modelling and European climate Risk Assessment) model ensemble, which is designed to address this type of question. Two blocking indices are used to evaluate the simulated mean blocking frequency and blocking persistence for the Euro-Atlantic and Pacific regions in winter and summer against the corresponding estimates from atmospheric reanalysis data. There is robust evidence that CMIP6 models simulate blocking frequency and persistence better than CMIP5 models in the Atlantic and Pacific and during winter and summer. This improvement is sizeable so that, for example, winter blocking frequency in the median CMIP5 model in a large Euro-Atlantic domain is underestimated by 33 % using the absolute geopotential height (AGP) blocking index, whereas the same number is 18 % for the median CMIP6 model. As for the sensitivity of simulated blocking to resolution, it is found that the resolution increase, from typically 100 to 20 km grid spacing, in most of the PRIMAVERA models, which are not re-tuned at the higher resolutions, benefits the mean blocking frequency in the Atlantic in winter and summer and in the Pacific in summer. Simulated blocking persistence, however, is not seen to improve with resolution. Our results are consistent with previous studies suggesting that resolution is one of a number of interacting factors necessary for an adequate simulation of blocking in GCMs. The improvements reported in this study hold promise for further reductions in blocking biases as model development continues.
Singularidades poéticas da hiperconexão: usos de links eletrônicos em poemas de Marie Bélisle
Authors: Pereira Vinícius 
Published: June 2020

Não obstante sua relevância na história das concepções de texto e das tecnologias digitais, a noção de hipertexto frequentemente se esvazia na academia, seja pela inflação semântica a que é submetido para designar dinâmicas de linguagem muito distintas, seja pelo fato de que praticamente todos os discursos na Internet se organizam de modo hipertextual/hipermidiático. Mais especificamente no que tange à literatura eletrônica – campo artístico em franca expansão –, as pesquisas precisam ir além da constatação da organização hipertextual das obras digitais; nesse sentido, devem buscar entender as singulares operações poéticas que o hipertexto pode ensejar e seus respectivos efeitos de sentido. Nessa direção, o presente artigo propõe uma leitura de hiperpoemas de Alter ego, Figures e Lames, desenvolvidos em Flash pela artista québecquense Marie Bélisle. Nessa análise, enfocaremos as operações poéticas engendradas pelo recurso de hiperlinks, para tanto propondo uma categorização de poéticas hipertextuais de alternância, expansão e redistribuição.
Paraffin Immunofluorescence Increases Light-Chain Detection in Extra-Renal Light Chain Amyloidosis and Other Light-Chain–Associated Diseases
Authors: Gibier Jean-Baptiste , Perbet Romain , Lopez Benjamin , Colombat Magali , Dubois Romain , Humez Sarah , Terriou Louis , Copin Marie-Christine , Gnemmi Viviane 
Published: June 2020

Context.—
Distinguishing the different types of amyloid is clinically important because treatments and outcomes are different. Mass spectrometry is the new gold standard for amyloid typing, but it is costly and not widely available. Therefore, immunolabeling remains the first step in identifying the most common types of amyloidosis. In amyloid subtyping, direct immunofluorescence works well when applied to frozen sections, but immunohistochemistry on formalin-fixed, paraffin-embedded material often yields poor results, particularly for light chain amyloidosis. Recently, paraffin immunofluorescence has been described as a valuable salvage technique in renal pathology when frozen sections are not available but it has not been evaluated for extra-renal diseases.

Objectives.—
To evaluate the use of paraffin immunofluorescence for light-chain detection in extra-renal amyloidosis and other light-chain–associated diseases.

Design.—
First, we compared the staining intensity of both light chains between paraffin immunofluorescence and immunohistochemistry on a retrospective cohort of 28 cases of amyloidosis that have been previously typed. Then, we studied the role of paraffin immunofluorescence as an addition to our classical immunohistochemistry panel for amyloidosis typing.

Results.—
In the retrospective cohort, we found that paraffin immunofluorescence outperformed immunohistochemistry for light-chain detection. Then, in the prospective part of the study, we showed that the proportion of correctly classified cases increased from 50% to 71.9% with the adjunction of second-intention paraffin immunofluorescence to the immunohistochemistry procedure.

Conclusions.—
We therefore view paraffin immunofluorescence as a significant addition to the routine workflow for detection of light-chain–related diseases.
RANS Based CFD Investigation of the Interference Between Two Boats Sailing Upwind
Authors: Boehm Christoph , Graf Kai 
Published: June 2020

Two sailboats sailing in close proximity will influence each other's wind field. Depending on their relative positions, positive or negative aerodynamic interference may occur. This phenomenon is generally known to sailors and well understood in a qualitative manner. However, it is of great value for aerodynamicists, performance analysts and tacticians to gain a quantitative understanding of this phenomenon. Modern CFD methods allow extensive flow visualization and are therefore helpful to improve our understanding of flow interference.
This paper describes the results of numerical simulations of the aerodynamic interference of two Elliot 6m sailboats sailing upwind. The simulations were performed using methods based on the solution of the Reynolds Averaged Navier Stokes Equations, so called RANSE-solvers. A broad range of relative positions of the two sailboats were investigated and the differences in boat speed were quantified. The results show that, for a situation where the two boats sail directly abeam of each other, neither of them has an advantage. However, for a situation where the boats sail even with respect to a regatta start line, the leeward boat is able to achieve a quite large speed advantage of 0.2 knots.