bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computer-aided therapeutic diagnosis for anorexia
Authors: Spinczyk Dominik , Bas Mateusz , Dzieciątko Mariusz , Maćkowski Michał , Rojewska Katarzyna , Maćkowska Stella 
Published: June 2020

Abstract
Background
Anorexia nervosa is a clinical disorder syndrome of the wide spectrum without a fully recognized etiology. The necessary issue in the clinical diagnostic process is to detect the causes of this disease (e.g., my body image, food, family, peers), which the therapist gradually comes to by verifying assumptions using proper methods and tools for diagnostic process. When a person is diagnosed with anorexia, a clinician (a doctor, a therapist or a psychologist) proposes a therapeutic diagnosis and considers the kind of treatment that should be applied. This process is also continued during therapeutic diagnosis. In both cases, it is recommended to apply computer-aided tools designed for testing and confirming the assumptions made by a psychologist. The paper aims to present the computer-aided therapeutic diagnosis method for anorexia. The proposed method consists of 4 stages: free statements of a patient about his/her body image, the general sentiment analysis of statement based on Recurrent Neural Network, assessment of the intensity of five basic emotions: happiness, anger, sadness, fear and disgust (using the Nencki Affective Word List and conversion of words to their basic form), and the assessment of particular areas of difficulties—the sentiment analysis based on the dictionary approach was applied.

Results
The sentiment analysis of a document achieved 72% and 51% of effectiveness, respectively, for RNN and dictionary-based methods. The intensity of sadness (emotion) occurring within the dictionary method is differentiated between control and research group at the level of 10%.

Conclusion
The quick access to the sentiment analysis of a statement on the image of patient’s body, emotions experienced by the patient and particular areas of difficulties of people prone to the anorexia nervosa disorders, may help to establish the diagnosis in a very short time and start an immediate therapy. The proposed automatic method helps to avoid patient’s aversions towards the therapy, which may include avoiding patient–therapist communication, talking about less essential topics, coming late for the sessions. These circumstances can guarantee promising prognosis for recovering.
Well-being is more than happiness and life satisfaction: a multidimensional analysis of 21 countries
Authors: Ruggeri Kai , Garcia-Garzon Eduardo , Maguire Áine , Matz Sandra , Huppert Felicia A. 
Published: June 2020

Abstract
Background
Recent trends on measurement of well-being have elevated the scientific standards and rigor associated with approaches for national and international comparisons of well-being. One major theme in this has been the shift toward multidimensional approaches over reliance on traditional metrics such as single measures (e.g. happiness, life satisfaction) or economic proxies (e.g. GDP).

Methods
To produce a cohesive, multidimensional measure of well-being useful for providing meaningful insights for policy, we use data from 2006 and 2012 from the European Social Survey (ESS) to analyze well-being for 21 countries, involving approximately 40,000 individuals for each year. We refer collectively to the items used in the survey as multidimensional psychological well-being (MPWB).

Results
The ten dimensions assessed are used to compute a single value standardized to the population, which supports broad assessment and comparison. It also increases the possibility of exploring individual dimensions of well-being useful for targeting interventions. Insights demonstrate what may be masked when limiting to single dimensions, which can create a failure to identify levers for policy interventions.

Conclusions
We conclude that both the composite score and individual dimensions from this approach constitute valuable levels of analyses for exploring appropriate policies to protect and improve well-being.
TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter
Authors: Wang Jingjie , Zhang Yitong , Zhuo Qin , Tseng Yujen , Wang Jiucun , Ma Yanyun , Zhang Jun , Liu Jie 
Published: June 2020

Abstract
Background
As a lipid metabolic disorder, non-alcoholic fatty liver disease (NAFLD) is an important cause of cirrhosis and hepatocellular carcinoma, with no effective drug up to date. Previous studies have demonstrated increased methylation levels of key genes in NAFLD, suggesting that hydroxymethylation, a key step in demethylation, may be a possible strategy to reverse NAFLD. TET1 is well known as a key hydroxymethylase, however, its role and mechanism in NAFLD remains unclear.

Methods
In this study, we utilized TET1 knockout mice, fed with high-fat diet. Furthermore, by ChIP and hMeDIP. TET1 knockdown L02 and HepG2 cell lines.

Results
Their degree of liver steatosis was more severe than that of wild-type mice, suggesting that TET1 had a significant protective effect against NAFLD. We further found that PPARα, a key regulator of fatty acid oxidation, and its downstream key enzymes ACOX1 and CPT1A, as well as the fatty acid oxidation product β-HB were significantly decreased in TET1 knockout mice. While the key genes for fatty acid synthesis and uptake were not significantly changed, suggesting that TET1 inhibits NAFLD by promoting fatty acid oxidation via PPARα pathway. TET1 was confirmed to directly bind to the promoter of PPARα and elevate its hydroxymethylation level.

Conclusions
This study is the first to show that TET1 can activate PPARα, promote fatty acid oxidation and inhibit NAFLD progression by hydroxymethylation of PPARα promoter, which may be a new strategy to reverse NAFLD.
Quantitative measures of health policy implementation determinants and outcomes: a systematic review
Authors: Allen Peg , Pilar Meagan , Walsh-Bailey Callie , Hooley Cole , Mazzucca Stephanie , Lewis Cara C. , Mettert Kayne D. , Dorsey Caitlin N. , Purtle Jonathan , Kepper Maura M. , Baumann Ana A. , Brownson Ross C. 
Published: June 2020

Abstract
Background
Public policy has tremendous impacts on population health. While policy development has been extensively studied, policy implementation research is newer and relies largely on qualitative methods. Quantitative measures are needed to disentangle differential impacts of policy implementation determinants (i.e., barriers and facilitators) and outcomes to ensure intended benefits are realized. Implementation outcomes include acceptability, adoption, appropriateness, compliance/fidelity, feasibility, penetration, sustainability, and costs. This systematic review identified quantitative measures that are used to assess health policy implementation determinants and outcomes and evaluated the quality of these measures.

Methods
Three frameworks guided the review: Implementation Outcomes Framework (Proctor et al.), Consolidated Framework for Implementation Research (Damschroder et al.), and Policy Implementation Determinants Framework (Bullock et al.). Six databases were searched: Medline, CINAHL Plus, PsycInfo, PAIS, ERIC, and Worldwide Political. Searches were limited to English language, peer-reviewed journal articles published January 1995 to April 2019. Search terms addressed four levels: health, public policy, implementation, and measurement. Empirical studies of public policies addressing physical or behavioral health with quantitative self-report or archival measures of policy implementation with at least two items assessing implementation outcomes or determinants were included. Consensus scoring of the Psychometric and Pragmatic Evidence Rating Scale assessed the quality of measures.

Results
Database searches yielded 8417 non-duplicate studies, with 870 (10.3%) undergoing full-text screening, yielding 66 studies. From the included studies, 70 unique measures were identified to quantitatively assess implementation outcomes and/or determinants. Acceptability, feasibility, appropriateness, and compliance were the most commonly measured implementation outcomes. Common determinants in the identified measures were organizational culture, implementation climate, and readiness for implementation, each aspects of the internal setting. Pragmatic quality ranged from adequate to good, with most measures freely available, brief, and at high school reading level. Few psychometric properties were reported.

Conclusions
Well-tested quantitative measures of implementation internal settings were under-utilized in policy studies. Further development and testing of external context measures are warranted. This review is intended to stimulate measure development and high-quality assessment of health policy implementation outcomes and determinants to help practitioners and researchers spread evidence-informed policies to improve population health.

Registration
Not registered
Anaphylaxis to clindamycin following cutaneous exposure
Authors: Paradis N. , Marois L. , Paradis L. , Graham F. , Bégin P. , Des Roches A. 
Published: June 2020

Abstract
Background
The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.

Case presentation
We describe the first case of intravenous clindamycin anaphylaxis, with likely sensitization due to previous topical exposure to clindamycin gel for acne in a 14-year-old boy with history of atopy and mild atopic dermatitis.

Conclusion
This case highlights the potential sensitization to drug allergens, including antibiotics, via the skin.
Existence of infinitely many high energy solutions for a class of fractional Schrödinger systems
Authors: Li Qi , Zhao Zengqin , Du Xinsheng 
Published: June 2020

AbstractIn this paper, we investigate a class of nonlinear fractional Schrödinger systems $$ \left \{ \textstyle\begin{array}{l@{\quad}l}(-\triangle)^{s} u +V(x)u=F_{u}(x,u,v),& x\in \mathbb{R}^{N}, \\(-\triangle)^{s} v +V(x)v=F_{v}(x,u,v),& x\in\mathbb{R}^{N}, \end{array}\displaystyle \right . $${(−△)su+V(x)u=Fu(x,u,v),x∈RN,(−△)sv+V(x)v=Fv(x,u,v),x∈RN, where $s\in(0, 1)$s∈(0,1), $N>2$N>2. Under relaxed assumptions on $V(x)$V(x) and $F(x, u, v)$F(x,u,v), we show the existence of infinitely many high energy solutions to the above fractional Schrödinger systems by a variant fountain theorem.
A COVID-19 case report from asymptomatic contact: implication for contact isolation and incubation management
Authors: Zhu Chang-Qiang , Gao Shi-Ding , Xu Yan , Yang Xiao-Hong , Ye Fu-Qiang , Ai Le-Le , Lv Rui-Chen , Zhang Bin , Li Yin , Lv Heng , Liu Yun-Sheng , Shi Chun-Meng , Wang Chun-Hui , Tan Wei-Long 
Published: June 2020

Abstract
Background
As of 2 March, 2020, at least 80 151 coronavirus disease 2019 (COVID-19) cases were reported in China. Most of the patients had a history of visiting Hubei Province or contacting with people who had ever stayed in or passed by Hubei Province or were exposed to symptoms. Some patients got infected through only asymptomatic contact. This study aimed to report the epidemic features and lab identification of a patient confirmed with COVID-19 infection through only asymptomatic contact.

Case presentation
A 44-year-old man, who lived in Nanchang, Jiangxi Province, China until 6 March 2020, suffered from cough on 27 January 2020. Fever symptoms appeared on 28 January, with a maximum temperature of 38.8 °C, accompanied by cough, sore throat, headache, fatigue, muscle ache, joint ache, and other symptoms. The symptoms continued until he was hospitalized on 30 January. Coronavirus conventional polymerase chain reaction assay was positive for the throat swab sample. The patient, along with his wife and son, drove from Nanchang to back to Honghu City, Hubei Province, on 23 January 2020. After staying with his parents and brother’s family for 3 days, the patient drove back to Nanchang and arrived on 25 January. On the way back home, they stopped by Tongshan service area, Hubei Province, without any close contact with other people. After arriving home in Nanchang City, Jiangxi Province, none of them left their residence. In addition, his parents stayed at home for 20 days with his younger brother’s family before they got back. His younger brother and one of his brother’s children visited Wuhan on 5 January and came home on 6 January 2020.

Conclusions
This report suggested that, in the early phase of COVID-19 pneumonia, routine screening could miss patients who were virus carriers. Highlighting travel history is of paramount importance for the early detection and isolation of severe acute respiratory syndrome coronavirus 2 cases.
Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy
Authors: Takaichi Yuta , Chambers James K. , Inoue Hiroyuki , Ano Yasuhisa , Takashima Akihiko , Nakayama Hiroyuki , Uchida Kazuyuki 
Published: June 2020

AbstractNeurodegenerative diseases are characterized by the accumulation of specific phosphorylated protein aggregates in the brain, such as hyperphosphorylated tau (hp-tau) in tauopathies and phosphorylated α-synuclein (p-αSyn) in α-synucleinopathies. The simultaneous accumulation of different proteins is a common event in many neurodegenerative diseases. We herein describe the detection of the phosphorylation and dimerization of αSyn and activation of GSK-3β, a major kinase known to phosphorylate tau and αSyn, in the brains of rTg4510 mice that overexpress human P301L mutant tau. Immunohistochemistry showed p-αSyn aggregates in rTg4510 mice, which were suppressed by doxycycline-mediated decreases in mutant tau expression levels. A semi-quantitative analysis revealed a regional correlation between hp-tau and p-αSyn accumulation in rTg4510 mice. Furthermore, proteinase K-resistant αSyn aggregates were found in the region with excessive hp-tau accumulation in rTg4510 mice, and these aggregates were morphologically different from proteinase K-susceptible p-αSyn aggregates. Western blotting revealed decreases in p-αSyn monomers in TBS- and sarkosyl-soluble fractions and increases in ubiquitinated p-αSyn dimers in sarkosyl-soluble and insoluble fractions in rTg4510 mice. Furthermore, an activated form of GSK-3β was immunohistochemically detected within cells containing both hp-tau and p-αSyn aggregates. A semi-quantitative analysis revealed that increased GSK-3β activity strongly correlated with hp-tau and p-αSyn accumulation in rTg4510 mice. Collectively, the present results suggest that the overexpression of human P301L mutant tau promoted the phosphorylation and dimerization of endogenous αSyn by activating GSK-3β in rTg4510 mice. This synergic effect between tau, αSyn, and GSK-3β may be involved in the pathophysiology of several neurodegenerative diseases that show the accumulation of both tau and αSyn.
Effects of afforestation of agricultural land with grey alder (Alnus incana (L.) Moench) on soil chemical properties, comparing two contrasting soil groups
Authors: Nikodemus Oļģerts , Kaupe Dārta , Kukuļs Imants , Brūmelis Guntis , Kasparinskis Raimonds , Dauškane Iluta , Treimane Agita 
Published: June 2020

Abstract
Background
Natural afforestation of former agricultural lands with alder species is common in Europe. Symbiotic nitrogen fixation by actinomycetes associated with alder species has been widely used for improvement of soil properties of abandoned agricultural lands, but relatively little is known of the interactions of these processes with soil type and chemical composition. We conducted a space-for time study with soil sampling under and outside grey alder tree canopies on two different soil groups to explore effects of colonisation of former agricultural lands by alder on soil properties.

Results
The results were analysed using analysis of variance. During the first 25 years after afforestation of former agricultural lands there was a significant increase in content of Ctot, Ntot, K+, Fe3+, Mn2+ and available P in the topsoil (0–10 cm and 11–20 cm) of Dystric Arenosols soils, which are deficient in organic matter. Such trends were not evident in organic matter rich Endostagnic Umbrisols soils, in which exchangeable K+ concentration decreased and exchangeable Fe3+ and Al3+ concentration increased.

Conclusions
The results show that the effects of grey alder on soil chemical properties depend on initial soil properties. The invasion of agricultural land by grey alder leads to spatial variability of soil chemical properties creating a mosaic pattern.
Invasive solid papillary carcinoma with neuroendocrine differentiation of the breast: a case report and literature review
Authors: Lin Xue , Matsumoto Yoshiaki , Nakakimura Tomomi , Ono Kazuo , Umeoka Shigeaki , Torii Masae , Yoshibayashi Hiroshi , Toi Masakazu 
Published: June 2020

Abstract
Background
Solid papillary carcinoma (SPC) of the breast is a rare breast cancer that accounts for less than 1% of all breast cancers. The optimal clinical management of SPC remains controversial. Here, we report a case of invasive SPC with neuroendocrine differentiation in addition to review of the current literature.

Case presentation
A premenopausal 46-year-old female presented with a mass in her left breast that tended to increase in size over a 10-month period. Mammography and ultrasonography revealed a mass in the left upper-inner quadrant. The resulting images suggested a category 3 breast tumor according to the Breast Imaging Reporting and Data System (BI-RADS). A core needle biopsy (CNB) was performed, and the pathological findings showed a solid papillary pattern and atypical cells suggestive of noninvasive SPC. After a left partial mastectomy and sentinel lymph node biopsy (SLNB), the specimens were sent for histopathological analysis for further investigation. Postoperative pathological findings suggested invasive SPC. Whole-breast radiation therapy and adjuvant hormonal therapy were performed as postoperative treatments. Three years after surgery, multiple lung metastases were detected, and the patient was treated with a gonadotropin-releasing hormone agonist and an aromatase inhibitor. Five months later, multiple liver metastases and bone metastases appeared, and oral 5-fluorouracil was chosen for the subsequent treatment. The patient has been treated for 5 years to date, and she is continuing to take oral 5-fluorouracil and is alive without any further disease progression.

Conclusions
We report a rare case of premenopausal invasive SPC with multiple metastases. Further study is needed to clarify the molecular characteristics and clinical behaviors of SPC and to explore the optimal treatment strategy.
Comparison of efficiency between platelet rich plasma and corticosteroid injection therapies in patients with Carpal tunnel syndrome: a prospective randomized controlled study
Authors: Hashim Noha Ali , Fathy Hala Ahmed , Esawy Marwa Mohammed , Shabana Marwa Ahmed 
Published: June 2020

AbstractBackgroundCarpal tunnel syndrome (CTS) is the most common upper limb entrapment neuropathy caused by compression of the median nerve as it traverses the wrist at the carpal tunnel.ObjectivesTo compare the effect of single dose of platelet-rich plasma (PRP) injected locally with that of corticosteroid in patients with CTS.Subjects and methodsA total of 60 patients with very mild to moderate unilateral CTS were recruited to the study. PRP was prepared via two centrifugation procedures. The patients were randomly divided into three groups PRP [i] group, PRP [ii] group, and a third group that received local corticosteroid injection (CS). The patients were followed up at 1.5 and 3 months by visual analog scale (VAS) for pain assessment. The severity and functional outcomes were evaluated through Boston CTS, and neurophysiological analyses were carried out.ResultsOn comparing the PRP [i], PRP [ii], and CS groups, a statistically significant enhancement of all outcome variables was observed in both PRP groups at follow-up except VAS at 3 and 6 months (P= 0.073 andP= 0.068, respectively) in PRP [ii] group.ConclusionIn CTS, PRP was a better treatment alternative with respect to pain and functional outcome. In addition, it was associated well with improved neurophysiological values than those observed after corticosteroid injection.Trial registrationZagazig University, ZU-IRB#5014. Registered 18 December 2018, http://www.IRB_123@medicine.zu.edu.eg. ISRCTN Registry,ISRCTN16755281; 20 March 2020
3-h drain clamping is not effective to reduce total blood loss after primary total knowledge
Authors: Park Dojoon , Choi Youn Ho , Cho Kwang Hyun , Koh Hae Seok 
Published: June 2020

Abstract
Purpose
Total knee arthroplasty (TKA) is a clinically efficacious surgical option for end-stage knee osteoarthritis. However, TKA increases the risk of serious bleeding and blood transfusion. The objective of this study was to evaluate the difference in postoperative blood loss in groups subjected to 3 h of clamping and non-clamping and determine the variations in rate and amount of transfusion after TKA between the two groups.

Materials and methods
Propensity score matching of the group subjected to 3-h drain clamping (43 patients; September 2015 to April 2016) and the control group (43 patients; before initiating the clamping method) was performed in patients undergoing unilateral primary posterior stabilized TKA. The two groups were compared. We measured the total drained blood volume until the drain was removed 48 h after surgery, and we compared the preoperative levels of hemoglobin and hematocrit with levels observed on days 1 and 2 after surgery. We also determined the blood transfusion rate and volume as well as the occurrence of clamping-associated complications.

Results
In the group subjected to 3-h drain clamping, the mean volume of total drained blood was significantly lower than in the control group (333.8 ± 190.2 mL vs. 839.9 ± 339.8 mL, P <0.001). There was no significant difference in total blood loss between the two groups (1226.9 ± 488.1 mL vs. 1127.1 ± 424.5 mL, P = 0.315), but the hidden blood loss was significantly higher in the 3-h drain clamping group than in the control group (893.1 ± 487.7 mL vs. 294.7 ± 531.8 mL, P <0.001). Both the transfusion rate and amount in the 3-h drain clamped group were higher than in the control group but were not statistically significant (30.2% vs. 37.2%, P = 0.494 and 269.8 ± 483.8 mL vs. 316.3 ± 158.2 mL, P = 0.648, respectively). No significant differences in complications, including deep vein thrombosis, pulmonary thromboembolism, and oozing, were noted between the two groups (all, P = 1.000).

Conclusions
The 3-h drain clamping method after primary TKA using posterior stabilized implant reduced the loss of postoperative drained blood. However, hidden blood loss was significantly higher in the 3-h drain clamping group; as a result, there were no differences in total blood loss and transfusion rate. The clamping method did not significantly alter the complication rate.