bluuebunny/crossref_metadata_2025_split huggingface dataset:
QuitSMART Utah: an implementation study protocol for a cluster-randomized, multi-level Sequential Multiple Assignment Randomized Trial to increase Reach and Impact of tobacco cessation treatment in Community Health Centers
Authors: Fernandez Maria E. , Schlechter Chelsey R. , Del Fiol Guilherme , Gibson Bryan , Kawamoto Kensaku , Siaperas Tracey , Pruhs Alan , Greene Tom , Nahum-Shani Inbal , Schulthies Sandra , Nelson Marci , Bohner Claudia , Kramer Heidi , Borbolla Damian , Austin Sharon , Weir Charlene , Walker Timothy W. , Lam Cho Y. , Wetter David W. 
Published: January 2020

Abstract
Background
Tobacco use remains the leading cause of death and disability in the USA and is disproportionately concentrated among low socioeconomic status (SES) populations. Community Health Centers (CHCs) are a key venue for reaching low SES populations with evidence-based tobacco cessation treatment such as Quitlines. Electronic health record (EHR)-based interventions at the point-of-care, text messaging (TM), and phone counseling have the potential to increase Quitline reach and are feasible to implement within CHCs. However, there is a lack of data to inform how, when, and in what combination these strategies should be implemented. The aims of this cluster-randomized trial are to evaluate multi-level implementation strategies to increase the Reach (i.e., proportion of tobacco-using patients who enroll in the Quitline) and Impact (i.e., Reach × Efficacy [efficacy is defined as the proportion of tobacco-using patients who enroll in Quitline treatment that successfully quit]) and to evaluate characteristics of healthcare system, providers, and patients that may influence tobacco-use outcomes.

Methods
This study is a multilevel, three-phase, Sequential Multiple Assignment Randomized Trial (SMART), conducted in CHCs (N = 33 clinics; N = 6000 patients). In the first phase, clinics will be randomized to two different EHR conditions. The second and third phases are patient-level randomizations based on prior treatment response. Patients who enroll in the Quitline receive no further interventions. In phase two, patients who are non-responders (i.e., patients who do not enroll in Quitline) will be randomized to receive either TM or continued-EHR. In phase three, patients in the TM condition who are non-responders will be randomized to receive either continued-TM or TM + phone coaching.

Discussion
This project will evaluate scalable, multi-level interventions to directly address strategic national priorities for reducing tobacco use and related disparities by increasing the Reach and Impact of evidence-based tobacco cessation interventions in low SES populations.

Trial registration
This trial was registered at ClinicalTrials.gov (NCT03900767) on April 4th, 2019.
Impact of a low FODMAP diet on the amount of rectal gas and rectal volume during radiotherapy in patients with prostate cancer – a prospective pilot study
Authors: Schaefer Christian , Zamboglou Constantinos , Volegova-Neher Natalja , Martini Carmen , Nicolay Nils Henrik , Schmidt-Hegemann Nina-Sophie , Rogowski Paul , Li Minglun , Belka Claus , Müller Arndt-Christian , Grosu Anca-Ligia , Brunner Thomas 
Published: January 2020

AbstractBackgroundSmall inter- and intrafractional prostate motion was shown to be a prerequisite for precise radiotherapy (RT) of prostate cancer (PCa) to achieve good local control and low rectal toxicity. As rectal gas and rectal volume are known to have a relevant effect on prostate motion, this study aims to reduce these parameters by using a Low FODMAP Diet (LFD) and to show feasibility of this intervention.MethodsWe compared a prospective intervention group (IG,n = 25) which underwent RT for PCa and whose patients were asked to follow a LFD during RT with a retrospective control group (CG,n = 25) which did not get any dietary advice. In the planning CT scan and all available cone beam CT scans rectal gas was classified based on a semiquantitative score (scale from 1 to 5) and rectal volume was measured. Furthermore, patients’ compliance was evaluated by a self-assessment questionnaire.ResultsClinical and treatment characteristics were well balanced between both groups. A total of 266 (CG, 10.6 per patient) and 280 CT scans (IG, 11.2 per patient), respectively, were analysed. The frequency distribution of gas scores differed significantly from each other (p < .001) with the IG having lower scores. Rectal volume was smaller in the IG (64.28 cm3, 95% CI 60.92–67.65 cm3, SD 28.64 cm3) than in the CG (71.40 cm3, 95% CI 66.47–76.32 cm3, SD 40.80 cm3) (p = .02). Mean intrapatient standard deviation as a measure for the variability of rectal volume was 22 cm3in the IG and 23 cm3in the CG (p = .81). Patients’ compliance and contentment were satisfying.ConclusionsThe use of a LFD significantly decreased rectal gas and rectal volume. LFD was feasible with an excellent patients’ compliance. However, prospective trials with a larger number of patients and a standardized evaluation of gastrointestinal toxicity and quality of life are reasonable.Trial registrationGerman Clinical Trials Register, DRKS00012955. Registered 29 August 2017 - Retrospectively registered,https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00012955
Multisession radiosurgery for intracranial meningioma treatment: study protocol of a single arm, monocenter, prospective trial
Authors: Pinzi V. , Marchetti M. , De Martin E. , Cuccarini V. , Tramacere I. , Ghielmetti F. , Fumagalli M. L. , Iezzoni C. , Fariselli L. 
Published: January 2020

Abstract
Background
Single session radiosurgery represents a widely accepted treatment for intracranial meningiomas. However, this approach could involve a high risk of treatment-related complications when applied to large volume lesions. In these cases and for those not suitable for surgical resection, radiosurgery in multisession setting could represents a viable option. The literature results are reassuring in terms of correlated adverse events as well as in terms of tumor control. However, no prospective long-term results are available. In this scenario, we design a prospective monocentric phase II study, in order to verify the safety of a multisession radiosurgery schedule delivering 25 Gy in 5 daily fractions.

Methods
Patients diagnosed with large and/or near to critical structures, intracranial meningiomas have been treated by means of multisession radiosurgery in both exclusive and postoperative settings. The primary study aim is safety that has been being prospectively scored based on international scales, including NCI Common Toxicity criteria, version 4.03, Barrow Neurological Institute pain intensity score, Barrow Neurological Institute facial numbness score and House-Brackmann Facial Nerve Grading System for qualitative analysis. Secondary aim is treatment efficacy in terms of local control that has been being assessed on volumetric analysis.

Discussion
This is the first prospective phase II trial on multisession radiosurgery for large and/or near to critical structures intracranial meningiomas. If positive results will be found, this study could represent the starting point for a phase III trial exploring the role of multisession radiosurgery in the exclusive and postoperative radiation therapy treatment of intracranial meningiomas.

Trial registration
Trial registration: clinicaltrials.gov platform (Multisession Radiosurgery in Large Meningiomas –MuRaLM- identifier NCT02974127). Registered: November 28, 2016. Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02974127?term=radiosurgery&cond=Intracranial+Meningioma&draw=2&rank=1
Combined one-stage minimally invasive surgery for primary pulmonary carcinoma and mitral regurgitation
Authors: Huang Chengfeng , Yang Chao , Huang Jiawen , Liao Qiuying , Zhang Xiaoshen , Liao Shengjie 
Published: January 2020

Abstract
Background
We report the first successful short-term outcome of one-stage minimally invasive surgery (MIS) mitral valve repair and video-assisted thoracoscopic surgery (VATS) lobectomy.

Case presentation
We report the first successful short-term outcome of combined one-stage video-assisted thoracoscopic surgery lobectomy and minimally invasive surgery in a patient with operable primary right upper lobe adenocarcinoma and mitral regurgitation. Post- operative recovery was uneventful, and follow-up at 6 weeks confirmed an excellent surgical and oncologic outcome.

Conclusions
We think one-stage minimally invasive surgery (MIS) cardiac surgery and video-assisted thoracoscopic surgery (VATS) lobectomy would benefit patients with satisfactory cardiac and pulmonary function.
Falsely undetectable TSH in a euthyroid patient
Authors: Rahimkhani Monireh , Kazemian Kiana , Daryasari Rashid Ramezani 
Published: January 2020

Abstract
Background
Measuring thyroid hormone levels is essential and helpful in the diagnosis of thyroid diseases.

Case presentation
We had a patient with undetectable serum TSH level by the Siemens immunoassay, whereas by ELISA and Roche-Abott immunoassay, serum level of TSH was in the normal range.

Conclusion
If the result of TSH level revealed very low or undetectable through one specific method, it should not be considered necessarily as a symptom of hyperthyroidism. It is to be requested to measure by the other methods with other devices too.
Early universal use of oral progesterone for prevention of preterm births in singleton pregnancy (SINPRO study): protocol of a multicenter, randomized, double-blind, placebo-controlled trial
Authors: Cheung Ka Wang , Seto Mimi Tin Yan , Ng Ernest Hung Yu 
Published: January 2020

Abstract
Background
Preterm birth accounts for 75% of perinatal deaths and more than 50% of long-term neurological disabilities. For a singleton pregnancy, progesterone treatment is effective in prevention of preterm birth in women with an asymptomatic short cervix or a history of preterm birth. However, a large proportion of preterm births still is not currently preventable. The aim of this study is to determine whether early universal use of oral progesterone before 14 + 0 weeks of gestation can prevent preterm birth better than universal screening of cervical length at 18 + 0 to 23 + 6 weeks of gestation, followed by progesterone treatment in those with a short cervix in singleton pregnancy.

Methods
This is a multicenter, randomized, double-blind, placebo-controlled trial registered with ClinicalTrials.gov on 12 February 2018. Eligible consecutive pregnant women with singleton gestation attending antenatal outpatient clinics will be recruited after receiving counseling and signing the written consent form. Transvaginal cervical length measurement will be performed at recruitment (before 14 + 0 weeks of gestation) and between 18 + 0 and 23 + 6 weeks of gestation. After randomization, women will be randomly assigned to either the treatment group (oral dydrogesterone 10 mg three times daily) or the placebo group, and medication will be started before 14 + 0 weeks of gestation. Assigned groups will be unblinded if the cervical length is ≤ 25 mm between 18 + 0 and 23 + 6 weeks of gestation, and the management option for short cervix will be discussed (oral progesterone, vaginal progesterone, or cervical cerclage). The primary outcome is preterm birth before 37 + 0 weeks of gestation.

Discussion
Progesterone is used extensively in part of the in vitro fertilization program as luteal phase support, and it is not associated with teratogenicity. Universal progesterone supplementation may be a better approach to prevent preterm birth. This large, multicenter, randomized, double-blind, placebo-controlled trial will provide the best evidence, leading to the best strategy for the prevention of preterm birth.

Trial registration
ClinicalTrials.gov, NCT03428685. Registered on 12 February 2018.
Aspirin for metal stent in malignant distal common bile duct obstruction (AIMS): study protocol for a multicenter randomized controlled trial
Authors: Choi Jin Ho , Paik Woo Hyun , You Min Su , Lee Kyong Joo , Choi Young Hoon , Shin Bang-sup , Lee Sang Hyub , Ryu Ji Kon , Kim Yong-Tae 
Published: January 2020

Abstract
Background
Endoscopic retrograde biliary drainage (ERBD) is the treatment of choice for patients with malignant distal common bile duct (CBD) obstruction. Self-expandable metal stents (SEMS), which are commonly used in unresectable cases, have many clinical advantages, including longer stent patency. Although the expected patency of SEMS is around 8 months, it has recently been reported that the duration of SEMS’ patency in patients using aspirin is prolonged. Our study, therefore, aims to investigate the effect of aspirin on SEMS’ patency.

Methods/design
This is an investigator-initiated, prospective, multicenter, double-blind, randomized placebo-controlled trial that will be conducted from November 2017 in four tertiary centers in South Korea. We intend to include in our study 184 adult (aged ≥ 20 years) patients with malignant distal CBD obstruction for whom ERBD with SEMS was successfully performed. The patients will be randomly allocated to two groups, which will comprise patients who have either taken 100 mg aspirin or a placebo for 6 months after index ERBD. The primary outcome will be the rate of stent dysfunction, and the secondary outcomes will be the duration of patency, the rate of reintervention, and the occurrence of adverse events.

Discussion
The aspirin for metal stents in malignant distal common bile duct obstruction (AIMS) study should determine the efficacy of aspirin in maintaining metal-stent patency in patients with malignant distal CBD obstructive.

Trial registration
ClinicalTrials.gov, ID: NCT03279809. Registered on 5 September 2017.
Direct and indirect effects of predation and parasitism on the Anopheles gambiae mosquito
Authors: Ong’wen Fedinand , Onyango Patrick Ogola , Bukhari Tullu 
Published: January 2020

AbstractBackgroundA good understanding of mosquito ecology is imperative for integrated vector control of malaria. In breeding sites,Anopheleslarvae are concurrently exposed to predators and parasites. However, to our knowledge, there is no study on combined effects of predators and parasites on development and survival of larvae and their carry-over effects on adult survivorship and susceptibility to further parasite infection.MethodsThis study focused on effects of the nymphs of the dragonflyPantala flavescensand the parasitic fungusBeauveria bassianaonAnopheles gambiae, to determine: predation efficacy of nymphs againstAn. gambiaelarvae; development rate ofAn. gambiaelarvae in the presence of one, two or four constrained nymphs; efficacy ofB. bassianaagainstAn. gambiaelarvae at doses of 3, 6 and 12 mg; and survival of adult mosquitoes exposed toB. bassiana, following pre-exposure to a constrained predator and/or parasite at the larval stage. The experiments consisted of survival bioassays quantified as pupation day, or dead larvae and/or adults.ResultsNymphs had an average predation efficacy of 88.3% (95% CI: 87.5–89.1) at 24 hours, againstAn. gambiaelarvae. The presence of one or two nymphs reduced development time of larvae by 0.65 and 0.35 days, respectively. However, development time of larvae exposed to four nymphs was similar to the control larvae. Larvae exposed to 3, 6 and 12 mg ofB. bassianawere 2.0, 2.5 and 3.5 times more likely to die, respectively, compared to control larvae. Adults not pre-exposed, those pre-exposed to predator, parasite, or both were 45.8, 67.4, 50.9 and 112.0 times more likely to die, respectively, compared to control that were unexposed to predator or parasite, at larval and adult stage.ConclusionsThis study shows that both predator and parasite can reduce larval population ofAn. gambiae, and presence of predator cues decreases development time in breeding sites, as well as, increases the susceptibility of emerging adult to fungus. Predator and parasite both have an additive effect on survival of adults exposed toB. bassiana. Field studies are required for an in-depth understanding of predator and parasite influence on mosquito development time, survival and susceptibility in nature.
Complete monotonicity and inequalities related to generalized k-gamma and k-polygamma functions
Authors: Zhang Ju-Mei , Yin Li , You Hong-Lian 
Published: January 2020

AbstractIn this paper, we prove new complete monotonicity properties of some functions related to generalized k-gamma and k-polygamma functions. Applications of the results yield various new inequalities. In the end, double inequalities are constructed involving the k-generalized digamma and polygamma functions.
Positive periodic solutions for multiparameter nonlinear differential systems with delays
Authors: Chen Ruipeng , Li Xiaoya 
Published: January 2020

AbstractWe establish several criteria for the existence of positive periodic solutions of the multi-parameter differential systems
$$\left \{ \textstyle\begin{array}{l} u'(t)+a_{1}(t)g_{1}(u(t))u(t)=\lambda b_{1}(t)f(u(t-\tau_{1}(t)),v(t-\zeta_{1}(t))), \\ v'(t)+a_{2}(t)g_{2}(v(t))v(t)=\mu b_{2}(t)g(u(t-\tau_{2}(t)),v(t-\zeta_{2}(t))), \end{array}\displaystyle \right . $${u′(t)+a1(t)g1(u(t))u(t)=λb1(t)f(u(t−τ1(t)),v(t−ζ1(t))),v′(t)+a2(t)g2(v(t))v(t)=μb2(t)g(u(t−τ2(t)),v(t−ζ2(t))), where the functions $g_{1}, g_{2}:[0,\infty)\to[0,\infty)$g1,g2:[0,∞)→[0,∞) are assumed to be unbounded. The analysis in the paper relies on the classical fixed point index theory. Our main findings improve and complement some existing results in the literature.
Existence of positive ground state solutions to a nonlinear fractional Schrödinger system with linear couplings
Authors: Du Xinsheng , Mao Anmin , Liu Ke 
Published: January 2020

AbstractIn this paper, we investigate a nonlinear fractional Schrödinger system with linear couplings as follows:
$$ \textstyle\begin{cases} (-\Delta )^{\alpha }u+(1+a(x))u=F_{u}(u,v)+\lambda v,& \text{in } \mathbb{R}^{3}, \\ (-\Delta )^{\alpha }v+(1+b(x))v=F_{v}(u,v)+\lambda u,& \text{in } \mathbb{R}^{3}, \\ u,v\in H^{\alpha }(\mathbb{R}^{3}), \end{cases} $${(−Δ)αu+(1+a(x))u=Fu(u,v)+λv,in R3,(−Δ)αv+(1+b(x))v=Fv(u,v)+λu,in R3,u,v∈Hα(R3), where $(-\Delta )^{\alpha }, \alpha \in (0,1)$(−Δ)α,α∈(0,1), denotes the fractional Laplacian and $\lambda >0$λ>0 is the coupling parameter. Under some assumptions, we prove the existence of positive ground state solutions to the above system with the help of the method of Nehari manifold and concentration compactness lemma.
Some identities for degenerate complete and incomplete r-Bell polynomials
Authors: Kwon Jongkyum , Kim Taekyun , Kim Dae San , Kim Han Young 
Published: January 2020

AbstractIn this paper, we study degenerate complete and incomplete r-Bell polynomials. They are generalizations of the recently introduced degenerate r-Bell polynomials and degenerate analogues for the complete and incomplete r-Bell polynomials. We investigate some properties and identities for these polynomials. In particular, we give explicit formulas for the degenerate complete and incomplete r-Bell polynomials.
Estimation of the mean of the partially linear single-index errors-in-variables model with missing response variables
Authors: Qi Xin , Yu ZhuoXi 
Published: January 2020

AbstractIn this paper, we estimate the mean of the partially linear single-index errors-in-variables model with missing response variables. The linear covariate is measured with additive error, therefore missing is not random. Two special estimators are defined that include a semiparametric regression imputation estimator and a marginal average estimator. These estimators are shown to be asymptotically normal and have the same asymptotic variance. A simulation experiment is used to illustrate our proposed method.
Existence of solutions for integral boundary value problems of mixed fractional differential equations under resonance
Authors: Song Shiying , Cui Yujun 
Published: January 2020

AbstractIn this paper, we concerned the existence of solutions of the following nonlinear mixed fractional differential equation with the integral boundary value problem:
$$\left \{ \textstyle\begin{array}{l} {}^{C}D^{\alpha}_{1-} D^{\beta}_{0+}u(t)=f(t,u(t),D^{\beta +1}_{0+}u(t),D^{\beta}_{0+}u(t)),\quad 0< t< 1,\\ u(0)=u'(0)=0,\qquad u(1)=\int^{1}_{0}u(t)\,dA(t), \end{array}\displaystyle \right . $${D1−αCD0+βu(t)=f(t,u(t),D0+β+1u(t),D0+βu(t)),0<t<1,u(0)=u′(0)=0,u(1)=∫01u(t)dA(t), where ${}^{C}D^{\alpha}_{1-}$D1−αC is the left Caputo fractional derivative of order $\alpha\in(1,2]$α∈(1,2], and $D^{\beta}_{0+}$D0+β is the right Riemann–Liouville fractional derivative of order $\beta\in(0,1]$β∈(0,1]. The coincidence degree theory is the main theoretical basis to prove the existence of solutions of such problems.
Impulsive control on delayed feedback chaotic financial system with Markovian jumping
Authors: Rao Ruofeng , Zhong Shouming 
Published: January 2020

AbstractIn this paper, the global asymptotic stability of both the closed economy system and the open economy system is investigated under impulse control, and the obtained stability criteria improve the existing results in the previous literature, generalizing the stabilization from the closed economy system to the open economy system, and stabilizing the unstable equilibrium point with positive interest rate. Particularly, stability of the equilibrium point with positive interest rate is suitable for the open economic market of China, for the interest rates during different periods in China’s financial market are always some of positive percentages. Finally, numerical examples illustrate the effectiveness of the proposed methods.
The year 2020, a milestone in breaking the vicious cycle of poverty and illness in China
Authors: Wang Yun-Ping , Zhou Xiao-Nong 
Published: January 2020

AbstractMarking the end of the five-year programme initiated by the Chinese Government to lift more than 70 million people out of poverty, the year 2020 is a milestone. Poverty alleviation has moved strongly forward in China and the major health indicators are now better than the average of all middle- and high-income countries. However, the dual burden of infectious and chronic diseases remains a challenge with respect to achieving the health target in the United Nations 2030 Agenda for sustainable development goals (SDGs). In 2015, about 44% of the poor population in China were impoverished by illness but already in 2018, multi-sectoral actions delivered by the Health-related Poverty Alleviation programme had reduced the number almost by half. In the past three years 15 million poor people (98% of the poor population) with infectious and chronic diseases had been treated and taken care of thanks to financial support through multiple health insurance schemes and other governmental subsidies. This article discusses the lessons learnt with regard to health-related poverty alleviation in China with special reference to those still remaining impoverished by illness. Consolidation of the achievements reached and provision of basic needs to those still disadvantaged and in poor health will require a major improvement of accessibility to, and affordability of, health services. The next step towards enhanced productivity and better living conditions will involve upgrading of the capacity of health professionals in the poor regions, promotion of coherent efforts in health-related poverty alleviation and rural revitalization measures. As an additional measure, data monitoring and research on health poverty alleviation should be strengthened as they are essential to generate the evidence and knowledge needed to support the move in the direction envisioned by the SDGs, and the new Healthy China 2030 programme.