bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphometric Study on the Mandible of Colobine Fossil (Mesopithecus pentelicus) Found in East Asia, a Comparison With Extant Taxa
Authors: Pan Hao , Ji Xueping , Youlatos Dionisios , Chen Ying , Zhang He , Guo Gaigai , Wang Jing , Huang Kang , Hou Rong , He Gang , Guo Songtao , Zhang Pei , Li Baoguo , Pan Ruliang 
Published: December 2024

ABSTRACTA tooth‐bearing mandible fossil of a colobine monkey discovered at Shuitangba, Zhaotong, Yunnan, China, was morphometrically analyzed and compared with extant Asian colobines. Our previous qualitative and quantitative descriptions indicate that it can be safely attributed to Mesopithecus pentelicus, a Miocene fossil colobine widely found in Europe and South Asia. The present research aims to explore fossil association with extant colobines and functionally propose its dietary preferences based on multivariate morphometric analyses of mandibular morphology. The results indicate that this fossil species presents a mosaic association with extant langurs (Presbytis, Trachypithecus, and Semnopithecus) and odd‐nosed monkeys (Pygathrix, Nasalis, and Rhinopithecus), with most similarities of size‐related traits and size‐adjusted shapes, and a notable difference from extant Rhinopithecus, due to the increased body size of the latter since the Pliocene. The allometric analysis showed that, like the fossils of the same species in other sites, its mandibular structure appears more adapted to crushing hard seed shells than chewing leaves. Moreover, our findings also imply that the Asian colobines significantly modified their dietary preferences over the last 6 million years following the ecological and environmental changes triggered by the accelerated uplift of the Qinghai‐Tibet Plateaus and severe monsoons. Morphologically, the more developed condyle length and moment arms of the temporomandibular joint and medial pterygoid muscles appear to accommodate a more folivorous dietary selection, functionally related to the intake of rigid fibers in leaves that require frequent one or two‐side mandibular chewing and grinding.
Individual and joint associations between sleep duration and physical activity with cognitive function: A longitudinal analysis among middle‐aged and older adults in China
Authors: Liu Hongwei , Shi Yan , Yu Min , Guo Xiaolei , Ruan Ye , Qin Fei , Zhou Rongfei , Feng Jingyuan , Hu Zihan , Wu Fei , Jia Qingqing , Yin Yanlu , Guo Yanfei , Wu Fan 
Published: December 2024

AbstractINTRODUCTIONStudies using cross‐sectional data or with a short follow‐up period fail to distinguish whether the associations between sleep duration and physical activity with cognitive function result from reverse causation.METHODSThe longitudinal study examined the individual and joint associations, with specific temporality, between sleep duration and physical activity with cognitive function, using time‐lagged linear mixed models and generalized additive mixed models.RESULTSA total of 14,694 participants aged ≥ 50 years were included, with an average lagged time of 4.5 (standard deviation 1.3) years. Long sleep duration was independently associated with cognitive decline, while short sleep duration and physical activity were not. The analysis of joint effects showed that increased physical activity slowed the rate of cognitive decline among participants reporting long sleep duration, consistent with the results of the stratified analyses.DISCUSSIONInterventions on improving sleep should consider concurrent physical activity to maximize benefits for slowing cognitive decline.Highlights
Long sleep duration was independently associated with worse cognitive function, while short sleep duration was not.
Elevated levels of physical activity were not independently associated with better cognitive function.
Increased physical activity appeared to mitigate the negative impact of long sleep duration on cognitive function.
Photonic Spin Hall Effect of Nanoparticles: Fundamentals, Advances, and Applications
Authors: Khan Aizaz , Gu Xiaoying , Gao Lei , Novitsky Andrey , Gao Dongliang 
Published: December 2024

AbstractThe net angular momentum of light remains conserved during propagation. This conservation leads to a spin transport which becomes evident when light encounters a refractive index gradient, i.e., when it is reflected, refracted, or scattered. The phenomenon is so‐called as the spin‐orbit interaction (SOI) of light has paved the way to manipulate the light‐matter interaction at the nanoscale and has remained the core of many recent studies. Particularly, the photonic spin Hall effect (PSHE) which is the microscopic spin splitting into circular polarization has given rise to novel applications, for example, precision metrology. The PSHE is well explored at planar interfaces, however much less attention is given to it when the optical potential gradient is of higher dimensionality, i.e., for nanoparticles. In this review, the theoretical description of the PSHE as well as the SOI in the scattering of light from nanoparticles are covered. Recent advances and trends in the PSHE in nanoparticles are reviewed. The review is concluded with suggestions for some novel directions in the field of PSHE of nanoparticles.
Low‐Temperature Cured and High‐Toughness Epoxy Resin Modified by Triblock Liquid Rubber
Authors: Fang Yiliang , Cai Lifeng , Deng Chongqing , Ma Xiaoyan , Wang Luyao 
Published: December 2024

ABSTRACTLow‐temperature cured epoxy resin (EP) is a suitable resin system for bonding thermal and temperature‐sensitive devices, which can also reduce energy consumption and production costs. In order to further broaden the application range of low‐temperature curing EP systems in amine‐sensitive environments, in addition to selecting a well‐compatible curing agent, an effective rubber to form a three‐dimensional network structure with the resin matrix, so as to significantly improve the toughness of the EP. In this work, two kinds of triblock liquid rubber hydroxy‐terminated polypropylene glycol‐polybutadiene‐polypropylene glycol (HTPO‐PB‐PO) and hydroxy‐terminated polyphenylethylene oxide‐polybutadiene‐polyphenylethylene oxide (HTSO‐PB‐SO) with controlled molecular weight are synthesized and adopted to improve the mechanical properties of cured EP with methyl hexahydro phthalic anhydride (MEHHPA). It is found that all triblock liquid rubber‐modified epoxy systems can be cured below 100°C, and the curing mechanism is similar to that of the pure EP system. Compared with the original pure EP, the impact resistance of modified samples is significantly improved, and the glass transition temperature (T

g
) is similar, among which the best impact strength of modified EP can reach 16.22 kJ/m2, 62.7% higher than that of the pure sample with only slightly reduced thermal decomposition temperature. These results can provide a low‐temperature curing resin material with excellent mechanical properties, high dimensional accuracy, and high heat resistance for amine‐sensitive environments while reducing costs due to high‐temperature components and energy consumption.
Anionic Photoacid Generator Bound Polymer Photoresists With Improved Performance for Advanced Lithography Patterning
Authors: Zhuang Changchang , Chen Jiao , Wang Tao , Zhao Jun , Li Haoyuan , Xin Hanshen , Zhang Jianhua 
Published: December 2024

ABSTRACTChemically amplified resist (CAR) has gained considerable attention in the realm of extreme ultraviolet lithography (EUVL) due to their exceptional photosensitivity, high resolution, and commercialization. This work presents the development of an anionic photoacid generator (PAG) bound polymer (PGM) photoresist composed of three rationally selected monomeric units: 2‐Phenyl‐2‐propyl methacrylate (PPMA), γ‐butyrolactone‐3‐yl methacrylate (GBLMA), and triphenyl sulfonium salt 1,1,2‐trifluorobutanesulfonate methacrylate (MTFBS‐TPS). Electron beam lithography (EBL) studies demonstrate that the PGM photoresist functions as a positive tone photoresist with commendable sensitivity (27.9 μC/cm2) and contrast (6.53). When compared under similar conditions, with equal amounts of PAG and identical processing, the PGM photoresist exhibited superior pattern fidelity, ease of handling, and higher line resolution (25 nm) relative to the triphenyl sulfonium triflate (TPS‐OTF) blend polymer (PG‐T) photoresist. This enhancement is probably caused by anionic PAG directly attaching to the polymer backbone, which mitigates acid diffusion during the post‐exposure baking (PEB) process. Moreover, the PGM photoresist obtained a pattern of 37.5 nm at 50 mJ/cm2 in the EUVL test. The positive tone resists were successfully applied for the fabrication of nanoscale patterns.
Scleractinian Corals at Their Subtropical Southwestern Atlantic Limit: Post‐2019 Mass Bleaching Event Analysis
Authors: Roos Natália C. , Longo Pedro A. S. , Ilieva Jéssica R. , Motta Fábio S. , Pereira‐Filho Guilherme H. 
Published: December 2024

ABSTRACTThermal anomalies caused by climate change have emerged as a major threat to reef ecosystems globally. While the effects of warming oceans have been extensively investigated in tropical reefs, its effects on subtropical reefs, where coral diversity is lower, remain largely unstudied. We analysed the spatial distribution, mean cover and health status of scleractinian corals in the subtropical rocky reefs of the Alcatrazes Archipelago, a no‐take marine protected area located 30 km off the coast of São Paulo state, Brazil (24° S). Data were collected before (2018) and after (2022) the most intense marine heatwave ever recorded in the region, in 2019, using either fixed or random photoquadrats. Five scleractinian corals were recorded as follows: The zooxanthellate massive species Mussismilia hispida and Madracis decactis, the azooxanthellate solitary corals Astrangia spp. and Coenocyathus sebroecki and the invasive sun coral Tubastraea spp. M. hispida and M. decactis were the most abundant species, particularly in the sheltered sites, while Astrangia spp. and C. sebroecki were less abundant and only recorded in the exposed side of the island. In the single site where Tubastraea spp. colonies prevailed, other coral species were nearly absent. Both M. hispida and M. decactis exhibited resilience to the 2019's bleaching event, with their abundance remaining almost the same in 2022. Our findings add evidences to the emerging idea that subtropical reefs in the southwestern Atlantic may serve as refuges during future thermal anomalies, highlighting the importance of monitoring these reefs in the context of changing habitats driven by warming oceans.
Metabarcoding Reveals Meiofaunal Diversity in Rhodolith Beds From SE Brazil
Authors: Coppo Gabriel C. , Netto Sergio A. , Pais Fabiano S. , Mazzuco Ana Carolina A. , Halanych Ken M. , Bernardino Angelo F. 
Published: December 2024

ABSTRACTRhodolith beds (RBs) are known to increase the seabed complexity and act as a hotspot, supporting a unique biodiversity. This increased structural complexity due to the presence of rhodolith nodules is expected to influence benthic diversity at a local scale. To investigate this further, we tested the hypothesis that high‐density rhodolith beds hold higher meiofaunal diversity than low‐density beds. We used metabarcoding (V9 hypervariable region from 18S SSU rRNA) on sediment samples from a region with extensive rhodolith beds in the Eastern Brazil Marine Ecoregion, with distinct areas covered by high‐ and low‐density beds. The sediment underneath high‐density beds showed higher food availability (biopolymeric carbon) and organic matter quality (protein content and protein‐to‐carbohydrate ratio); however, meiofaunal composition and phylogenetic diversity was similar among all rhodolith beds sampled in the study area. Shannon's diversity was lower in high‐density beds, which may be attributed to the higher organic matter content and quality supporting strong competitors, such as crustaceans and annelids that may dominate and suppress the presence of other meiofaunal taxa. Our results showed that rhodolith beds host a number of meiofaunal zoobenthos that are rarely sampled with traditional morphology‐based methods, and we suggest that metabarcoding may become an important complementary method to study rhodolith beds globally. As assessing biodiversity is a prerequisite for any conservation measures, this study can provide insights when managing valuable marine habitats.
5‐methyl‐2‐carboxamidepyrrole‐based novel dual mPGES‐1/sEH inhibitors as promising anticancer candidates
Authors: Colarusso Ester , Lauro Gianluigi , Potenza Marianna , Galatello Paola , Garigliota Maria Luisa d'Aulisio , Ferraro Maria Grazia , Piccolo Marialuisa , Chini Maria Giovanna , Irace Carlo , Campiglia Pietro , Hoffstetter Robert Klaus , Werz Oliver , Ramunno Anna , Bifulco Giuseppe 
Published: December 2024

AbstractInhibiting microsomal prostaglandin E2 synthase‐1 (mPGES‐1), an inducible enzyme involved in prostaglandin E2 (PGE2) biosynthesis and tumor microenvironment (TME) homeostasis, is a valuable strategy for treating inflammation and cancer. In this work, 5‐methylcarboxamidepyrrole‐based molecules were designed and synthesized as new compounds targeting mPGES‐1. Remarkably, compounds 1f, 2b, 2c, and 2d were able to significantly reduce the activity of the isolated enzyme, showing IC50 values in the low micromolar range. With the aim of further profiling the synthesized molecules, their ability to interfere with the activity of soluble epoxide hydrolase (sEH), whose inhibition blocks the loss of the anti‐inflammatory mediators epoxyeicosatrienoic acids (EETs or epoxyicosatrienoic acids), was investigated in silico and by employing specific biological assays. Among the set of tested compounds, 1f, 2b, 2c, and 2d emerged as mPGES‐1/sEH dual inhibitors. Moreover, given that overexpression of mPGES‐1 has been observed in many human tumors, we finally explored the biological effect of our compounds in an in vitro model of human colorectal cancer (CRC). The obtained outcomes pave the way for future investigation to optimize and further characterize anticancer pharmacological profile of the carboxamidepyrrole‐based molecules.
Die Nachhaltigkeitszertifizierung von Büroimmobilien gewinnt an Relevanz
Authors: Barthauer Matthias 
Published: December 2024

AbstractDGNB, LEED und BREEAM sind die führenden Green‐Building‐Zertifizierungssysteme für Immobilien in Deutschland. Der Anteil der zertifizierten Büroimmobilien am gesamten Bestand in den sieben wichtigsten Märkten beträgt im Schnitt 14 %, wobei der Anteil in Frankfurt am Main mit 27 % mit Abstand am höchsten ausfällt. Insbesondere Banken und Finanzdienstleister mieten überdurchschnittlich häufig Flächen in zertifizierten Büroimmobilien an. Aus Investorensicht hat die Zertifizierung eine positive Auswirkung auf die erzielbare Miete. Der Effekt liegt zwischen 0,4 % in Toplagen und 6,8 % in Drittlagen.
Treatment decision regret after precision prostatectomy: An analysis of patient‐reported outcomes predicting decision regret
Authors: Kolanukuduru Kaushik P. , Jeong Wooju , Pistin Larisa , Abdollah Firas , Tewari Ash K. , Menon Mani 
Published: December 2024

AbstractObjectivesThis study aimed to assess postoperative decision regret (DR) after precision prostatectomy (PP), a novel subtotal surgical technique for prostate cancer (PCa) that involves the preservation of the unilateral capsule and seminal vesicle, and to identify factors predictive of DR after PP.Materials and MethodsAfter a shared decision‐making process, 128 patients underwent PP for the treatment of localised PCa. Given the subtotal nature of the surgery, patients were informed about the possibility of a detectable prostate‐specific antigen and secondary treatment. Between 6 and 12 months of follow‐up, DR was analysed using the previously validated decision regret score (DRS). A univariable linear regression analysis was performed to analyse factors predictive of DR after PP.ResultsBetween 6 and 12 months after PP, objective measurements of DR were obtained on 64 patients who completed the DRS. At the time of DRS, 16 patients were impotent (SHIM < 17), while six were incontinent (≥1 pad/day). The median time to DRS was 10 months (IQR 7.5–11.8). Only two patients (3.1%) reported significant DR after PP (DRS > 25), while 53 patients (83%) reported no regret (DRS = 0). The median DRS was 0 (0–0). Incontinence and impotence at the time of DRS predicted higher DR after PP (incontinence estimate: 11.3 ± 3.2, p < 0.001; impotence estimate: 5.4 ± 2.3, p = 0.02).ConclusionsThe incidence of DR after PP is low, with only 3% of patients reporting significant regret. Patients who are either incontinent or impotent after PP are more likely to regret their decision. Further studies with larger sizes and longer follow‐ups are required to measure the longitudinal trends in DR after PP.
Copper–Cobalt Nanozyme Mimicking Laccase for Sensitive Colorimetric Determination of Cannabidiol in Food and Cosmetics
Authors: Wang Le , Li Qiulan , Yang Dezhi , Yang Yaling , Zhu Yanqin , Yin Qinhong 
Published: December 2024

ABSTRACTIn colorimetric analysis, nanozymes are invaluable tools due to their simple production, long‐lasting stability, and adaptable enzymatic activity, which enable them to induce changes in substrate color. In this study, a simple nanozyme‐based colorimetric sensor was developed to detect cannabidiol (CBD) by using the laccase activity of the self‐made MOF with copper and cobalt loading (Cu/Co@MOF) nanozyme, which was synthesized using a one‐pot microwave method. The Cu/Co@MOF has the ability to catalyze the coupling reaction between 4‐AP and various phenolic substrates, thereby converting colorless phenolic substrates into red substances. Notably, 16 ng/mL was the limit of detection. Based on Y = 0.137X + 0.003 equation, absorbance and CAN concentrations (0.067 to 10 μg/mL with a correlation value [R2] of 0.993) had a significant correlation. The developed colorimetric method was subsequently employed to determine CBD in facial masks and essential oil samples, resulting in relative standard deviations (RSDs) ranging from 1.4% to 4.3%. Therefore, this sensitive, cost‐effective, and rapid method ensures an effective determination of CBD in food and cosmetics.
Advancements in Plant Gene Editing Technology: From Construct Design to Enhanced Transformation Efficiency
Authors: Yuan Pu , Usman Muhammad , Liu Wenshan , Adhikari Ashna , Zhang Chunquan , Njiti Victor , Xia Ye 
Published: December 2024

ABSTRACTPlant gene editing technology has significantly advanced in recent years, thereby transforming both biotechnological research and agricultural practices. This review provides a comprehensive summary of recent advancements in this rapidly evolving field, showcasing significant discoveries from improved transformation efficiency to advanced construct design. The primary focus is on the maturation of the Clustered regularly interspaced short palindromic repeats/CRISPR‐associated protein (CRISPR/Cas)9 system, which has emerged as a powerful tool for precise gene editing in plants. Through a detailed exploration, we elucidate the intricacies of integrating genetic modifications into plant genomes, shedding light on transport mechanisms, transformation techniques, and optimization strategies specific to CRISPR constructs. Furthermore, we explore the initiatives aimed at extending the frontiers of gene editing to nonmodel plant species, showcasing the growing scope of this technology. Overall, this comprehensive review highlights the significant impact of recent advancements in plant gene editing, illuminating its transformative potential in driving agricultural innovation and biotechnological progress.
Investigating Task‐Free Functional Connectivity Patterns in Newborns Using Functional Near‐Infrared Spectroscopy
Authors: Vahidi Homa , Kowalczyk Alexandra , Stubbs Kevin , Musabi Melab , Roychaudhuri Sriya , Kent Michaela , Bhattacharya Soume , de Ribaupierre Sandrine , Lawrence Keith St. , Mohsenzadeh Yalda , Duerden Emma G. 
Published: December 2024

ABSTRACTBackgroundResting‐state networks (RSNs), particularly the sensorimotor network, begin to strengthe in the third trimester of pregnancy and mature extensively by term age. The integrity and structure of these networks have been repeatedly linked to neurological health outcomes in neonates, highlighting the importance of understanding the normative variations in RSNs in healthy development. Specifically, robust bilateral functional connectivity in the sensorimotor RSN has been linked to optimal neurodevelopmental outcomes in neonates.
AimIn the current study, we aimed to map the developmental trajectory of the sensorimotor RSN in awake neonates using functional near‐infrared spectroscopy (fNIRS).Materials & MethodsWe acquired fNIRS resting‐state data from 41 healthy newborns (17 females, gestational age ranging from 36 + 0 to 42 + 1 weeks) within the first week after birth. We performed both single channel and hemispheric analyses to investigate the relationship between functional connectivity and both gestational and postnatal age.ResultsWe observed robust positive connectivity in numerous channel‐pairs across the sensorimotor network, especially in the left hemisphere. Next, we examined the relationship between functional connectivity, gestational age, and postnatal age, while controlling for sex and subject effects. We found both gestational and postnatal age to be significantly associated with changes in functional connectivity in the sensorimotor RSN. In our hemispheric analysis (Ninterhemispheric = 10, Nleft intrahemispheric = 15, and Nright intrahemispheric = 9), we observed a significant positive relationship between interhemispheric connectivity and postnatal age.Discussion and ConclusionIn summary, our findings demonstrate the utility of fNIRS for monitoring early developmental changes in functional networks in awake newborns.
Impact of Clinical Characteristics and Treatment on Cholangiocarcinoma Prognosis in Southern Thailand
Authors: Sathitruangsak Chirawadee , Pattarapuntakul Tanawat , Kaewdech Apichat , Thongkan Tortrakoon , Prisutkul Apinya , Thongwatchara Phatcharaporn , Sriplung Hutcha , Kongkamol Chanon , Kanokwiroon Kanyanatt , Obchoei Sumalee , Sripongpun Pimsiri 
Published: December 2024

ABSTRACTBackgroundCholangiocarcinoma (CCA) is most commonly seen in Northeastern Thailand and other parts of Asia where liver flukes are prevalent. However, it is unknown whether CCA patients in low and high liver fluke prevalence areas are similar. This study aimed to analyze the clinical characteristics and outcomes of CCA patients in Southern Thailand.MethodsWe retrospectively reviewed 223 patients diagnosed with CCA between 2018 and 2021 in a tertiary‐care center. Clinicopathologic data were reviewed and compared between intrahepatic, perihilar, and distal CCA (iCCA, pCCA, and dCCA, respectively). Overall survivals (OS) were determined by Kaplan–Meier method and multivariable Cox regressions.ResultsThe mean age was 63.9 years; 50.7% were men. The most common subtype was iCCA (49.3%), followed by pCCA (36.3%) and dCCA (14.3%). Most patients were diagnosed at a later stage: 59.4% TMN stage IV and 23.3% stage III. Cirrhosis was present in 6.3%, while the presence of liver fluke was not detected. Only 15.1% of the cohort were deemed resectable. The median OS for iCCA, pCCA, and dCCA patients were 27.3, 22.0, and 19.3 weeks, respectively (p = 0.9). One‐year survival rate differed significantly between resectable and unresectable patients (85.2% vs. 21.2%, p < 0.0001). TMN stage (aHR 1.88), palliative biliary drainage (aHR 0.31), and systemic chemotherapy (aHR 0.19) were independent predictors for mortality in unresectable pCCA and dCCA patients. In unresectable iCCA patients, only systemic chemotherapy was significant (aHR 0.30).ConclusionMost patients were diagnosed late, and the median OS was only 5–6 months. Unresectable CCA patients with systemic chemotherapy and palliative biliary drainage had better survival rates.