bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensional hierarchy of higher-order topology in three-dimensional sonic crystals
Authors: Zhang Xiujuan , Xie Bi-Ye , Wang Hong-Fei , Xu Xiangyuan , Tian Yuan , Jiang Jian-Hua , Lu Ming-Hui , Chen Yan-Feng 
Published: November 2019

AbstractWave trapping and manipulation are at the heart of modern integrated photonics and acoustics. Grand challenges emerge on increasing the integration density and reducing the wave leakage/noises due to fabrication imperfections, especially for waveguides and cavities at subwavelength scales. The rising of robust wave dynamics based on topological mechanisms offers possible solutions. Ideally, in a three-dimensional (3D) topological integrated chip, there are coexisting robust two-dimensional (2D) interfaces, one-dimensional (1D) waveguides and zero-dimensional (0D) cavities. Here, we report the experimental discovery of such a dimensional hierarchy of the topologically-protected 2D surface states, 1D hinge states and 0D corner states in a single 3D system. Such an unprecedented phenomenon is triggered by the higher-order topology in simple-cubic sonic crystals and protected by the space group $${P}_{m\bar{3}m}$$Pm3 ¯m. Our study opens up a new regime for multidimensional wave trapping and manipulation at subwavelength scales, which may inspire future technology for integrated acoustics and photonics.
Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
Authors: McGrath Erica , Shin Hyunsu , Zhang Linyi , Phue Je-Nie , Wu Wells W. , Shen Rong-Fong , Jang Yoon-Young , Revollo Javier , Ye Zhaohui 
Published: November 2019

AbstractDNA base editors have enabled genome editing without generating DNA double strand breaks. The applications of this technology have been reported in a variety of animal and plant systems, however, their editing specificity in human stem cells has not been studied by unbiased genome-wide analysis. Here we investigate the fidelity of cytidine deaminase-mediated base editing in human induced pluripotent stem cells (iPSCs) by whole genome sequencing after sustained or transient base editor expression. While base-edited iPSC clones without significant off-target modifications are identified, this study also reveals the potential of APOBEC-based base editors in inducing unintended point mutations outside of likely in silico-predicted CRISPR-Cas9 off-targets. The majority of the off-target mutations are C:G->T:A transitions or C:G->G:C transversions enriched for the APOBEC mutagenesis signature. These results demonstrate that cytosine base editor-mediated editing may result in unintended genetic modifications with distinct patterns from that of the conventional CRISPR-Cas nucleases.
Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae
Authors: Heo Kyoo , Park Young-Ha , Lee Kyung-Ah , Kim Joonwon , Ham Hyeong-In , Kim Byung-Gee , Lee Won-Jae , Seok Yeong-Jae 
Published: November 2019

AbstractBiofilm formation protects bacteria from stresses including antibiotics and host immune responses. Carbon sources can modulate biofilm formation and host colonization in Vibrio cholerae, but the underlying mechanisms remain unclear. Here, we show that EIIAGlc, a component of the phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS), regulates the intracellular concentration of the cyclic dinucleotide c-di-GMP, and thus biofilm formation. The availability of preferred sugars such as glucose affects EIIAGlc phosphorylation state, which in turn modulates the interaction of EIIAGlc with a c-di-GMP phosphodiesterase (hereafter referred to as PdeS). In a Drosophila model of V. cholerae infection, sugars in the host diet regulate gut colonization in a manner dependent on the PdeS-EIIAGlc interaction. Our results shed light into the mechanisms by which some nutrients regulate biofilm formation and host colonization.
Nickel-molybdenum nitride nanoplate electrocatalysts for concurrent electrolytic hydrogen and formate productions
Authors: Li Yan , Wei Xinfa , Chen Lisong , Shi Jianlin , He Mingyuan 
Published: November 2019

AbstractHydrogen production by electrocatalytic water splitting is an efficient and economical technology, however, is severely impeded by the kinetic-sluggish and low value-added anodic oxygen evolution reaction. Here we report the nickel-molybdenum-nitride nanoplates loaded on carbon fiber cloth (Ni-Mo-N/CFC), for the concurrent electrolytic productions of high-purity hydrogen at the cathode and value-added formate at the anode in low-cost alkaline glycerol solutions. Especially, when equipped with Ni-Mo-N/CFC at both anode and cathode, the established electrolyzer requires as low as 1.36 V of cell voltage to achieve 10 mA cm−2, which is 260 mV lower than that in alkaline aqueous solution. Moreover, high Faraday efficiencies of 99.7% for H2 evolution and 95.0% for formate production have been obtained. Based on the excellent electrochemical performances of Ni-Mo-N/CFC, electrolytic H2 and formate productions from the alkaline glycerol solutions are an energy-efficient and promising technology for the renewable and clean energy supply in the future.
Interference between overlapping memories is predicted by neural states during learning
Authors: Chanales Avi J. H. , Dudukovic Nicole M. , Richter Franziska R. , Kuhl Brice A. 
Published: November 2019

AbstractOne of the primary contributors to forgetting is interference from overlapping memories. Intuitively, this suggests—and prominent theoretical models argue—that memory interference is best avoided by encoding overlapping memories as if they were unrelated. It is therefore surprising that reactivation of older memories during new encoding has been associated with reduced memory interference. Critically, however, prior studies have not directly established why reactivation reduces interference. Here, we first developed a behavioral paradigm that isolates the negative influence that overlapping memories exert during memory retrieval. We then show that reactivating older memories during the encoding of new memories dramatically reduces this interference cost at retrieval. Finally, leveraging multiple fMRI decoding approaches, we show that spontaneous reactivation of older memories during new encoding leads to integration of overlapping memories and, critically, that integration during encoding specifically reduces interference between overlapping, and otherwise competing, memories during retrieval.
Screen Printed Passives and Interconnects on Bio-Degradable Medical Hydrocolloid Dressing for Wearable Sensors
Authors: Alsuradi Haneen , Yoo Jerald 
Published: November 2019

AbstractThe healthcare system is undergoing a noticeable transformation from a reactive, post-disease treatment to a preventive, predictive continuous healthcare. The key enabler for such a system is a pervasive wearable platform. Several technologies have been suggested and implemented as a wearable platform, but these technologies either lack reliability, manufacturing practicability or pervasiveness. We propose a screen-printed circuit board on bio-degradable hydrocolloid dressings, which are medically used and approved, as a platform for wearable biomedical sensors to overcome the aforementioned problems. We experimentally characterize and prepare the surface of the hydrocolloid and demonstrate high-quality screen-printed passive elements and interconnects on its surface using conductive silver paste. We also propose appropriate models of the thick-film screen-printed passives, validated through measurements and FEM simulations. We further elucidate on the usage of the hydrocolloid dressing by prototyping a Wireless Power Transfer (WPT) sensor and a humidity sensor using printed spiral inductors and interdigital capacitors, respectively.
Silver-coated magnetic nanocomposites induce growth inhibition and protein changes in foodborne bacteria
Authors: Park Seong B. , White Shecoya B. , Steadman Christy S. , Pechan Tibor , Pechanova Olga , Clemente Henry J. , Thirumalai Rooban V. K. G. , Willard Scott T. , Ryan Peter L. , Feugang Jean M. 
Published: November 2019

AbstractCytotoxicity concerns of nanoparticles on animal or human bodies have led to the design of iron oxide core nanocomposites, coated with elemental silver to allow their magnetic removal from bio-mixtures. Although the antimicrobial effect of silver is well-described, the effects of nanoparticles derived from silver on microorganisms remain unfolded. Here, we characterized a customized magnetic silver nanocomposite (Ag-MNP) and evaluated its effects on bacterial growth and protein changes. The Ag-MNP displayed both longitudinal and round shapes under High-Resolution Transmission Electron Microscopy imaging, while the Energy Dispersive X-ray Spectroscopy and X-ray diffraction analysis confirmed the presence of Ag, Fe3O4 (Magnetite) and FeO2 (Goethite). Optical density, bioluminescence imaging, and Colony Forming Unit assessments revealed that the presence of Ag-MNP induced strong dose-dependent bacteria (Escherichia coli O157:H7, Salmonella enterica serovar Typhimurium and S. Anatum) growth inhibition. The TEM imaging showed penetration and infiltration of bacteria by Ag-MNP, leading to membrane degeneration and vacuole formation. The presence of Ag-MNP led to fifteen up-regulated and nine down-regulated proteins (P < 0.05) that are involved in cell membrane synthesis, inhibition of protein synthesis, interference with DNA synthesis, and energy metabolism inhibition. This study provides insights to develop alternative antimicrobials to treat foodborne pathogens with antibiotic resistance avoidance.
Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease
Authors: Ashfaq-Khan Muhammad , Aslam Misbah , Qureshi Muhammad Asif , Senkowski Marcel Sascha , Yen-Weng Shih , Strand Susanne , Kim Yong Ook , Pickert Geethanjali , Schattenberg Jörn M. , Schuppan Detlef 
Published: November 2019

AbstractWe previously demonstrated that a common dietary protein component, wheat amylase trypsin inhibitors (ATI), stimulate intestinal macrophages and dendritic cells via toll like receptor 4. Activation of these intestinal myeloid cells elicits an inflammatory signal that is propagated to mesenteric lymph nodes, and that can facilitate extraintestinal inflammation. Mice were fed a well-defined high fat diet, with (HFD/ATI) or without (HFD) nutritionally irrelevant amounts of ATI. Mice on HFD/ATI developed only mild signs of intestinal inflammation and myeloid cell activation but displayed significantly higher serum triglycerides and transaminases compared to mice on HFD alone. Moreover, they showed increased visceral and liver fat, and a higher insulin resistance. ATI feeding promoted liver and adipose tissue inflammation, with M1-type macrophage polarization and infiltration, and enhanced liver fibrogenesis. Gluten, the major protein component of wheat, did not induce these pathologies. Therefore, wheat ATI ingestion in minute quantities comparable to human daily wheat consumption exacerbated features of the metabolic syndrome and non-alcoholic steatohepatitis, despite its irrelevant caloric value.
Association between Information and Communication Technology use and Ocular Axial Length Elongation among Middle-Aged Male Workers
Authors: Honda Toru , Nakagawa Toru , Watanabe Yuya , Hayashi Takeshi , Nakano Tadashi , Horie Seichi , Tatemichi Masayuki 
Published: November 2019

AbstractThe use of Information and Communication Technology devices (ICT) has spread globally; therefore, increasing exposure to these display devices is an important health issue in the workplace. The association between ocular axial length (AL) elongation and ICT use was investigated among 7334 middle-aged Japanese male workers. Detailed ICT use information was obtained using a self-administered questionnaire. The high AL group was defined as the group with AL above the 75th percentile for each 5-year age interval. Logistic analysis showed that the odds ratio (OR) for the high AL group of >8 hours/day, adjusted for potent confounding factors, was significantly elevated relative to <1 hour/day. Notably, there was a strong association in the older groups (OR = 6.60, 95% CI = 3.92–11.12), based on work-related uses: word processing, sending e-mails, preparation of presentation materials, and browsing websites. In addition, among workers with extended ICT use for these work-related purposes, a significant lateral difference was observed in AL. However, these associations were not observed for private use, such as playing games. The results of our prospective cross-sectional study show that increased time spent on work-related ICT uses was associated with AL elongation, particularly in older workers.
Exceptional points in classical spin dynamics
Authors: Galda Alexey , Vinokur Valerii M. 
Published: November 2019

AbstractNon-conservative physical systems admit a special kind of spectral degeneracy, known as exceptional point (EP), at which eigenvalues and eigenvectors of the corresponding non-Hermitian Hamiltonian coalesce. Dynamical parametric encircling of the EP can lead to non-adiabatic evolution associated with a state flip, a sharp transition between the resonant modes. Physical consequences of the dynamical encircling of EPs in open dissipative systems have been explored in optics and photonics. Building on the recent progress in understanding the parity-time ($${\mathscr{P}}{\mathscr{T}}$$PT)-symmetric dynamics in spin systems, we use topological properties of EPs to implement chiral non-reciprocal transmission of a spin through the material with non-uniform magnetization, like helical magnet. We consider an exemplary system, spin-torque-driven single spin described by the time-dependent non-Hermitian Hamiltonian. We show that encircling individual EPs in a parameter space results in non-reciprocal spin dynamics and find the range of optimal protocol parameters for high-efficiency asymmetric spin filter based on this effect. Our findings offer a platform for non-reciprocal spin devices for spintronics and magnonics.
Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix)
Authors: Wang Xinhua , Liu Haiyang , Pang Meixia , Fu Beide , Yu Xiaomu , He Shunping , Tong Jingou 
Published: November 2019

AbstractHigh-density genetic map and quantitative trait loci (QTL) mapping are powerful tools for identifying genomic regions that may be responsible for such polygenic trait as growth. A high-density genetic linkage map was constructed by sequencing 198 individuals in a F1 family of silver carp (Hypophthalmichthys molitrix) in this study. This genetic map spans a length of 2,721.07 cM with 3,134 SNPs distributed on 24 linkage groups (LGs). Comparative genomic mapping presented a high level of syntenic relationship between silver carp and zebrafish. We detected one major and nineteen suggestive QTL for 4 growth-related traits (body length, body height, head length and body weight) at 6, 12 and 18 months post hatch (mph), explaining 10.2~19.5% of phenotypic variation. All six QTL for growth traits of 12 mph generally overlapped with QTL for 6 mph, while the majority of QTL for 18 mph were identified on two additional LGs, which may reveal a different genetic modulation during early and late muscle growth stages. Four potential candidate genes were identified from the QTL regions by homology searching of marker sequences against zebrafish genome. Hepcidin, a potential candidate gene identified from a QTL interval on LG16, was significantly associated with growth traits in the analyses of both phenotype-SNP association and mRNA expression between small-size and large-size groups of silver carp. These results provide a basis for elucidating the genetic mechanisms for growth and body formation in silver carp, a world aquaculture fish.
Determination of the Aspect-ratio Distribution of Gold Nanorods in a Colloidal Solution using UV-visible absorption spectroscopy
Authors: Kumar Rahul , Binetti Leonardo , Nguyen T. Hien , Alwis Lourdes S. M. , Agrawal Arti , Sun Tong , Grattan Kenneth T. V. 
Published: November 2019

AbstractKnowledge of the distribution of the aspect ratios (ARs) in a chemically-synthesized colloidal solution of Gold Nano Rods (GNRs) is an important measure in determining the quality of synthesis, and consequently the performance of the GNRs generated for various applications. In this work, an algorithm has been developed based on the Bellman Principle of Optimality to readily determine the AR distribution of synthesized GNRs in colloidal solutions. This is achieved by theoretically fitting the longitudinal plasmon resonance of GNRs obtained by UV-visible spectroscopy. The AR distribution obtained from the use of the algorithm developed have shown good agreement with those theoretically generated one as well as with the previously reported results. After bench-marking, the algorithm has been applied to determine the mean and standard deviation of the AR distribution of two GNRs solutions synthesized and examined in this work. The comparison with experimentally derived results from the use of expensive Transmission Electron Microscopic images and Dynamic Light Scattering technique shows that the algorithm developed offers a fast and thus potentially cost-effective solution to determine the quality of the synthesized GNRs specifically needed for many potential applications for the advanced sensor systems.
Replication of a Printed Volatile Mold: a novel microfabrication method for advanced microfluidic systems
Authors: Brossard Rémy , Brouchet Thomas , Malloggi Florent 
Published: November 2019

AbstractA novel and simple method to fabricate microchannels is reported based on an inkjet printing of a volatile solid mold. A liquid ink -1,6 hexanediol- ejected from a piezoelectric nozzle is instantaneously frozen when touching a cooled substrate. The created mold is then poured with PDMS. Once the PDMS is crosslinked, the ink is sublimated and the device is ready. With this approach it is possible to make microchannels on different nature surfaces such as glass, paper, uncross-linked PDMS layer or non planar substrates. The versatility of this method is illustrated by printing channels directly on commercial electrodes and measuring the channel capacitance. Moreover, millimetric height microfluidic systems are easily produced (aspect ratio $$\ge $$≥ 25) as well as 3D structures such as bridges. To demonstrate, we have fabricated a combinatorial microfluidic system which makes 6 mixtures from 4 initial solutions without any stacking and tedious alignment procedure.
Visualization and quantification of the degenerative pattern of the talus in unilateral varus ankle osteoarthritis
Authors: Seki Hiroyuki , Ogihara Naomichi , Kokubo Tetsuro , Suda Yasunori , Ishii Ken , Nagura Takeo 
Published: November 2019

AbstractThe aim of this study was to quantify and visualize the degenerative patterns of the talus in ankle osteoarthritis (OA). The differences in talar morphology between sides of patients with unilateral varus ankle OA (medial talar tilt > 4°) were compared. Computed tomography images of both feet of 35 patients (OA: 22 patients, control: 13 patients) were analyzed. Each surface model of the right and left tali was registered to the opposite talus via a mirror-image technique and an iterative closest point algorithm. The surface deviation between the two models was quantified and visualized by deviation color maps. The results quantitatively demonstrated that osteophytes are generated in the area under the antero-medial margin of the trochlea in OA tali. In severe OA tali, bone resorption of more than 2 mm in the medial portion of the trochlea, as well as a similar degree of osteophyte formation on the lateral surface, was also seen. Stereotypical patterns of degeneration occurring in OA tali were successfully visualized and quantified by left-right comparison of patients with unilateral ankle OA. Such information would contribute to better understanding of the development of ankle OA and preoperative planning of total ankle arthroplasty and arthrodesis.
Nano-scale characterisation of sheared β” precipitates in a deformed Al-Mg-Si alloy
Authors: Christiansen Emil , Marioara Calin Daniel , Holmedal Bjørn , Hopperstad Odd Sture , Holmestad Randi 
Published: November 2019

AbstractThis paper compares the nano-scale structure of β” precipitates in a peak-aged Al-Mg-Si alloy before and after deformation. Three complementary advanced transmission electron microscopy techniques are used to reveal the structures and elucidate the interaction between dislocations and β” precipitates. We show that the needle-like and semi-coherent β” precipitates are sheared several times on different planes by dislocations during deformation, with no indications that they are bypassed or looped. Our results show that dislocations cut through precipitates and leave behind planar defects lying on planes inclined to 〈100〉 directions inside the precipitates. The results also indicate that precipitates are sheared in single steps, and the implication of this observation is discussed in terms of slip behaviour.
Localization effect on AMS fabric revealed by microstructural evidence across small-scale shear zone in marble
Authors: Kusbach V. K. , Machek M. , Roxerová Z. , Racek M. , Silva P. F. 
Published: November 2019

AbstractAnisotropy of magnetic susceptibility (AMS) is regularly applied as a tool to infer structural analysis of deformation and flow in rocks, particularly, with low anisotropy. AMS integrates the magnetic signature of crystallographic and shape preferred orientation of all mineral grains present in the rock microstructure. Those preferred orientations result from multiple processes affecting the rock during its evolution, therefore the desirable AMS-strain relationship is not straightforward. Here we show that due to localization of deformation, AMS is indirectly dependent on the magnitude and character of deformation. In order to decipher the AMS-strain relationship, AMS studies should be accompanied by microstructural analyses combined with numerical modelling of magnetic fabric. A small-scale shear zone produced by single deformation event was studied. The resultant AMS fabric is “inverse” due to the presence of Fe-dolomite and controlled by calcite and dolomite crystallographic preferred orientations. The localized deformation resulted in the angular deviation between macroscopic and magnetic fabric in the shear zone, systematically increasing with increasing strain. This is a result of the presence of microstructural subfabrics of coarse porphyroclasts and fine-grained recrystallized matrix produced by localization.The localization of deformation is a multiscale and widespread process that should be considered whenever interpreting AMS in deformed rocks and regions.