bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain inhibition is not affected by exercise-induced pain
Authors: Szikszay Tibor M. , Adamczyk Waclaw M. , Wojtyna Ewa , Luedtke Kerstin 
Published: March 2020

Abstract

Introduction:
Offset analgesia (OA) and conditioned pain modulation (CPM) are frequently used paradigms to assess the descending pain modulation system. Recently, it was shown that both paradigms are reduced in chronic pain, but the influence of acute pain has not yet been adequately examined.

Objectives:
The aim of this study is to investigate OA and CPM after exercise-induced pain to evaluate whether these tests can be influenced by delayed-onset muscle soreness (DOMS) at a local or remote body site.

Methods:
Forty-two healthy adults were invited to 3 separate examination days: a baseline appointment, the consecutive day, and 7 days later. Participants were randomly divided into a rest (n = 21) and an exercise group (n = 21). The latter performed a single intensive exercise for the lower back. Before, immediately after, and on the following examination days, OA and CPM were measured at the forearm and the lower back by blinded assessor.

Results:
The exercise provoked a moderate pain perception and a mild delayed-onset muscle soreness on the following day. Repeated-measurements analysis of variance showed no statistically significant main effect for either OA or CPM at the forearm or lower back (P > 0.05).

Conclusion:
Delayed-onset muscle soreness was shown to have no effect on the inhibitory pain modulation system neither locally (at the painful body part), nor remotely. Thus, OA and CPM are robust test paradigms that probably require more intense, different, or prolonged pain to be modulated.
Trajectories of Viral Suppression in People Living With HIV Receiving Coordinated Care: Differences by Comorbidities
Authors: Li Michael J. , Su Erica , Garland Wendy H. , Oksuzyan Sona , Lee Sung-Jae , Kao Uyen H. , Weiss Robert E. , Shoptaw Steven J. 
Published: March 2020

Background:
In March of 2013, the Los Angeles County (LAC) Division of HIV and STD Programs implemented a clinic-based Medical Care Coordination (MCC) Program to increase viral suppression (VS) (<200 c/mL) among people living with HIV (PLWH) at high risk for poor health outcomes.

Objective:
This study aimed to estimate trajectories of VS and to assess whether these trajectories differed by stimulant use, housing instability, and depressive symptom severity as reported by PLWH participating in MCC.

Methods:
Data represent 6408 PLWH in LAC receiving services from the MCC Program and were obtained from LAC HIV surveillance data matched to behavioral assessments obtained across 35 Ryan White Program clinics participating in MCC. Piecewise mixed-effects logistic regression with a random intercept estimated probabilities of VS from 12 months before MCC enrollment through 36 months after enrollment, accounting for time by covariate interactions for 3 comorbid conditions: housing instability, stimulant use, and depressive symptoms.

Results:
The overall probability of VS increased from 0.35 to 0.77 within the first 6 months in the MCC Program, and this probability was maintained up to 36 months after enrollment. Those who reported housing instability, stimulant use, or multiple comorbid conditions did not achieve the same probability of VS by 36 months as those with none of those comorbidities.

Conclusions:
Findings suggest that MCC improved the probability of VS for all patient groups regardless of the presence of comorbidities. However, those with comorbid conditions will still require increased support from patient-centered programs to address disparities in VS.
The Effect of Topical Tacrolimus on Pedicled Flap Survival
Authors: Van Y-Vu Robert , Wald Gal , Lu Connie , Samadi Arash , Wright Matthew , Lara Daniel , Marano Andrew , Otterburn David M. 
Published: March 2020

Purpose
Skin necrosis is a known postoperative complication of mastectomies. The pathophysiology of tissue necrosis involves lymphatic congestion, followed by venous congestion and ultimately arterial insufficiency. Recent mouse model studies have shown topical tacrolimus to increase growth of lymphatic collateral vessels and decrease lymphedema, potentially obviating the cycle of necrosis and increasing skin survival. The purpose of this study was to investigate the effect of topical tacrolimus on skin flap necrosis in a rat model.

Methods
A cranially based dorsal skin flap measuring 3 × 10 cm was raised and reinset on 22 Sprague-Dawley rats. They were then randomized to either the control (topical petroleum jelly) or the treatment (topical 0.1% tacrolimus) arm. In addition, 0.2 g of either ointment was spread over the flap and then covered with an occlusive dressing. Dressings were changed daily with reapplication of both the topical ointment and occlusive dressing. The rats were sacrificed 7 days postoperatively; areas of viable tissue, reversible ischemia, and full thickness necrosis were measured with Fiji software, and comparative analysis was performed with GraphPad statistical software.

Results
The average area of the dorsal flaps in the control and tacrolimus groups was 22.5 and 23.9 cm2, respectively. In the control cohort, the average viable area was 42.4%, the average reversible ischemia area was 43.6%, and the average necrotic area was 13.9%. In the tacrolimus cohort, the average viable area was 31.5%, the average reversible ischemia area was 59.3%, and the average necrotic area was 9.2%. Total necrotic area was significantly lower in rats receiving topical tacrolimus as compared with controls (P = 0.015). Furthermore, the ratios of necrotic to reversible ischemia and necrotic to viable tissue were significantly lower in the tacrolimus group as compared with controls (P = 0.003, P = 0.015). There was one incidence of wound dehiscence secondary to rodent self-removal of dressings and suture that required reoperation and reinset.

Conclusions
Topical tacrolimus was associated with significantly less full thickness necrosis as compared with topical.
Perspectives on disruptive technology and innovation
Authors: Liu Wan , Liu Ren-huai , Chen Hui , Mboga Jet 
Published: March 2020

Purpose
Disruptive technology and innovation represent complex conflicts in nature. This paper aims to present an analytical review of the heterogeneity and conflicts that exist in the disruptive technology/innovation between the eastern and western countries using Chinese high-speed railways to illustrate disruptive innovation.

Design/methodology/approach
The emerging economy brings about other theoretical and practical conflicts. Qualitative analysis is conducted on Chinese high-speed railways to assess the validity of innovation characteristics using Professor Clayton M. Christensen’s theories of disruptive technology/innovation and conflict. The authors explore the conflicts that can accompany the introduction of disruptive technologies in the current platform and how appropriately this specific context can lessen these conflicts.

Findings
The study revealed that Christensen’s theories could be applied 100per cent to the Chinese context if the western disruptive innovation theory can meet the practical requirements of Chinese disruptive technology/innovation. Qualitative analysis showed that Chinese high-speed railways had experienced greater success with disruptive innovation mechanism. The authors conclude that while the Chinese market is critical in shaping the kind of innovations that are emerging there, many disruptive technologies/innovations in China have their roots in the low-end market and new market. Implications for theory and practice are discussed.

Originality/value
There exists a research gap in the literature on the Chinese context. Conflict of disruptive technology and innovation within China and the characteristics of the Chinese high-speed railway prompt further research for scholars and practitioners.
Trade diversion risk for halal food exports
Authors: Kabir Shahriar , Shams Syed , Lawrey Roger 
Published: March 2020

Purpose
The purpose of this paper is to investigate the link between trade diversion risk and new Halal market exploration.

Design/methodology/approach
This paper analyzes the Halal trade flows for Malaysia’s top 11 halal food/food-related commodities from 1967 to 2018 by relying on co-integration and auto-regression techniques.

Findings
This paper determines that the greater the country’s current comparative advantage in an exported good, the higher the risk of export diversion between the Halal and conventional markets. The diversion risk, however, disappears with a lower current comparative advantage.

Practical implications
To take advantage of the fast-emerging Halal market, a country should expand export of commodities with relatively low current comparative advantage but high demand in the target market, along with supportive trade policies to build competitiveness in the long term.

Originality/value
This study fills the gap in the literature by investigating if the theory of comparative advantage can predict the market diversification risk that may arise from the expansion of exports to the Halal market occurring alongside existing exports to the conventional market.
Controlling and enabling practices to manage supply in online service triads
Authors: van Kalsbeek Robert , Broekhuis Manda , Roodbergen Kees Jan 
Published: March 2020

Purpose
The purpose of this paper is to understand which controlling and enabling practices are used, how the numerous supplying partners are managed and how positive network effects are generated in online service triads (multi-sided platform – supplying partners – consumers).

Design/methodology/approach
A single representative in-depth case study was conducted to refine theory on managing service triads. The main data source consists of field notes collected by one author, who held a temporary position within the organization. Additional data were collected from observations, internal documents, informal talks and 20 interviews.

Findings
The authors found controlling and enabling organizational practices in four main categories on two levels as follows: managing network composition (system level), managing order fulfillment and returns (operations level), category management (both levels) and capability enhancement (both levels).

Research limitations/implications
The authors show that both controlling and enabling practices are present in online service triads. This enables platform owners and supplying partners to share responsibilities for creating positive network effects, i.e. to increase scale, which increases value, which again attracts more suppliers and consumers, which creates more value, etc.

Practical implications
The authors present a range of and controlling and enabling practices that describe how multi-sided platforms can manage numerous supplying partners in an online context.

Originality/value
This study is the first to show that contractual and relational governance is insufficient in service triads in online settings with numerous supplying partners. Further, the authors provide empirical evidence that supply networks continuously adapt over time.
Epidemiological features of rosacea in Changsha, China: A population‐based, cross‐sectional study
Authors: Li Jinglin , Wang Ben , Deng Yuxuan , Shi Wei , Jian Dan , Liu Fangfen , Huang Yingxue , Tang Yan , Zhao Zhixiang , Huang Xin , Li Ji , Xie Hongfu 
Published: March 2020

AbstractRosacea is a common chronic skin disorder of unknown etiology. While population prevalence rates range 0.2–22% in Europe and North America, prevalence in China is currently undetermined. We conducted a large population‐based case–control study to determine the present epidemiological status of rosacea in China, involving 10 095 participants aged 0–100 years (mean age, 35.5 ± 19.1; 50.5% female). A census of rosacea among 15 communities in Changsha in south central China was conducted with skin examination by board‐certified dermatologists. Rosacea was observed in 3.48% (95% confidence interval, 3.13–3.85%) of the study population. Subtype distribution was erythematotelangiectatic in 47.6%, papulopustular in 35.0% and phymatous in 17.4%. Family history was noted in 37.8% and ocular symptoms in 31.3%. Associations with rosacea were observed for melasma, hypertension, hyperthyroidism and breast cancer in females (P < 0.05), and also for hyperthyroidism and peptic ulcers in males (P < 0.05). Our results provide baseline information about epidemiological aspects of rosacea in China.
Surgical site infection caused by Aeromonas hydrophila presenting as necrotizing soft tissue infection after esophagectomy
Authors: Yamasaki Osamu , Takahashi Eizo , Noda Kazuyo , Kanaya Nobuhiko , Tanabe Shunsuke , Shirakawa Yasuhiro , Morizane Shin 
Published: March 2020

AbstractSeveral virulence factors of Aeromonas such as hemolysin, proteases and lipases have been characterized. The relationship between these virulence factors and disease remains unclear. A 71‐year‐old man underwent thoracoscopic esophagectomy, lymph node dissection and Roux‐en‐Y reconstruction for esophageal cancer. On postoperative day 1, redness around the wound on the thoracic abdominal wall gradually enlarged and necrosis became apparent with septic shock. Necrotizing soft tissue infection was suspected and emergency surgical debridement was performed. Blood and wound cultures were positive for Aeromonas hydrophila. The strain was found to have hemolytic activity, proteolytic activity and extremely high elastolytic activity. In addition, the strain actively produced elastolytic metalloprotease, which may contribute to extensive tissue necrosis.
DNA sequencing, genomes and genetic markers of microbes on fruits and vegetables
Authors: Shen Youming , Nie Jiyun , Kuang Lixue , Zhang Jianyi , Li Haifei 
Published: March 2020

SummaryThe development of DNA sequencing technology has provided an effective method for studying foodborne and phytopathogenic microorganisms on fruits and vegetables (F & V). DNA sequencing has successfully proceeded through three generations, including the tens of operating platforms. These advances have significantly promoted microbial whole‐genome sequencing (WGS) and DNA polymorphism research. Based on genomic and regional polymorphisms, genetic markers have been widely obtained. These molecular markers are used as targets for PCR or chip analyses to detect microbes at the genetic level. Furthermore, metagenomic analyses conducted by sequencing the hypervariable regions of ribosomal DNA (rDNA) have revealed comprehensive microbial communities in various studies on F & V. This review highlights the basic principles of three generations of DNA sequencing, and summarizes the WGS studies of and available DNA markers for major bacterial foodborne pathogens and phytopathogenic fungi found on F & V. In addition, rDNA sequencing‐based bacterial and fungal metagenomics are summarized under three topics. These findings deepen the understanding of DNA sequencing and its application in studies of foodborne and phytopathogenic microbes and shed light on strategies for the monitoring of F & V microbes and quality control.
Application of Bayesian causal inference and structural equation model to animal breeding
Authors: Inoue Keiichi 
Published: March 2020

AbstractOptimized breeding goals and management practices for the improvement of target traits requires knowledge regarding any potential functional relationships between them. Fitting a structural equation model (SEM) allows for inferences about the magnitude of causal effects between traits to be made. In recent years, an adaptation of SEM was proposed in the context of quantitative genetics and mixed models. Several studies have since applied the SEM in the context of animal breeding. However, fitting the SEM requires choosing a causal structure with prior biological or temporal knowledge. The inductive causation (IC) algorithm can be used to recover an underlying causal structure from observed associations between traits. The results of the papers, which are introduced in this review, showed that using the IC algorithm to infer a causal structure is a helpful tool for detecting a causal structure without proper prior knowledge or with uncertain relationships between traits. The reports also presented that fitting the SEM could infer the effects of interventions, which are not given by correlations. Hence, information from the SEM provides more insights into and suggestions on breeding strategy than that from a multiple‐trait model, which is the conventional model used for multitrait analysis.
Phase I study of imalumab (BAX69), a fully human recombinant antioxidized macrophage migration inhibitory factor antibody in advanced solid tumours
Authors: Mahalingam Devalingam , Patel Manish R. , Sachdev Jasgit C. , Hart Lowell L. , Halama Niels , Ramanathan Ramesh K. , Sarantopoulos John , Völkel Dirk , Youssef Ashraf , de Jong Floris A. , Tsimberidou Apostolia Maria 
Published: March 2020

AimPreclinical evidence suggests that oxidized macrophage migration inhibitory factor (oxMIF) may be involved in carcinogenesis. This phase 1 study (NCT01765790) assessed the safety, tolerability, pharmacokinetics and antitumour activity of imalumab, an oxMIF inhibitor, in patients with advanced cancer using ‘3 + 3’ dose escalation.MethodsIn Schedule 1, patients with solid tumours received doses from 1 to 50 mg/kg IV every 2 weeks. In Schedule 2, patients with metastatic colorectal adenocarcinoma, non‐small‐cell lung, or ovarian cancer received weekly doses of 10 or 25 mg/kg IV (1 cycle = 28 days). Treatment continued until disease progression, unacceptable toxicity, dose‐limiting toxicity, or withdrawal of consent.ResultsFifty of 68 enrolled patients received imalumab. The most common treatment‐related adverse events (TRAEs) included fatigue (10%) and vomiting (6%); four grade 3 serious TRAEs (two patients) occurred. The dose‐limiting toxicity was allergic alveolitis (one patient, 50 mg/kg every 2 weeks). The maximum tolerated and biologically active doses were 37.5 mg/kg every 2 weeks and 10 mg/kg weekly, respectively. Of 39 assessed patients, 13 had stable disease (≥4 months in 8 patients).ConclusionsImalumab had a maximum tolerated dose of 37.5 mg/kg every 2 weeks in patients with advanced solid tumours, with a biologically active dose of 10 mg/kg weekly. Further investigation will help define the role of oxMIF as a cancer treatment target.
Spatial behaviour of the Apennine hare: Are females territorial?
Authors: Lovari Sandro , Fattorini Niccolò , Calosi Martina , Cozzi Francesca , Gabbrielli Chiara , Giari Chiara , Torniai Letizia , Romeo Giorgia , Mori Emiliano 
Published: March 2020

AbstractThe spatial behaviour of seven male and five female Apennine hares Lepus corsicanus was studied in a scrub‐wood area of Central Italy, through radiotracking. The median percentage of home‐range overlap was about five times lower between females (< 15%) than between males (75%). Intrasexual aggression was recorded for females, but never for males. No species within the Lepus genus are known to be territorial, whereas we suggest that inter‐individual female intolerance in the Apennine hare may be compatible with territoriality. The Apennine hare is also unusual among hares because it reproduces throughout the year, that is also during food‐poor months, which could have triggered resource defence between females to maximise their reproductive fitness.
Fracture behaviour analysis of the full‐graded concrete based on digital image correlation and acoustic emission technique
Authors: Xiangqian Fan , Shengtao Li , Xudong Chen , Saisai Liu , Yuzhu Guo 
Published: March 2020

AbstractThree‐point bending tests of the full‐graded concrete under different loading rates were carried out. The cracks were quantitatively analyzed by digital image correlation (DIC). The toughening mechanism during the crack development process was observed, and there are obvious crack branching and aggregate interlocking during the crack propagation. At the same load level, the crack opening width increases with the increase of the loading rate. DIC detects a decrease in the tortuosity of the fracture morphology. And at the same time, the damage of the dam concrete was evaluated by the frequency analysis and the damage type analysis from acoustic emission (AE) signals. The signal strength increases at a higher loading rate as well as the tensile type cracks. The results show that the monitoring results of DIC and AE technique are in agreement with each other, which is very effective for determining the fracture behaviour of concrete materials.HighlightsThe aggregate interlocking and crack branching form the toughening mechanism after peakThe interlocking and crack branching decrease with the increase of the loading rate.Signals with different frequency content correspond to different fracture scale.The development type of crack tends to direct tension with the increase of the rate.
Effects of pasture age on the genotype and phenotype of perennial ryegrass
Authors: Faville Marty J. , Crush James R. , Hong Won , Phillips Holly , Lee Julia M. , Chapman David 
Published: March 2020

AbstractLimited persistence of perennial ryegrass (Lolium perenne L.) in dairy pastures is a significant issue in parts of New Zealand. The contribution of plant genetic background to this problem is not well understood. Temporal changes were investigated in genotypic and phenotypic composition of two perennial ryegrass cultivars (Nui SE and Alto AR37, older and newer cultivars respectively) sown as fields plots at three locations. Samples from survivor populations collected annually over 6 years from each location were established in a field nursery, analysed by simple sequence repeat (SSR) markers and assessed for vigour, leaf morphology and tiller number. SSR‐based estimates of the statistic G′ST indicated no significant (p > .05) genetic differentiation between survivor populations and plants grown from remnant seed (ex‐seed) after 5 years, and no significant change (p > .05) in within‐population genetic diversity for either cultivar at any location. SSR analysis of endophytic fungus (Epichloë festucae var. lolii) type revealed only limited ingress of off‐type ryegrass volunteers into plots at two locations. Vigour scores of survivor plants were not significantly (p > .05) different among plants collected from different locations and ex‐seed plants. Leaves on ex‐seed plants were longer (p < .001) than those on the survivor plants after four but not 6 years and may reflect a short‐term response to climatic conditions experienced in the field nursery. Our results suggest that the reported poor ryegrass persistence is not driven by changes in population genetic structure and that the sown cultivars survived and remained true to type.