bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan antara Frekuensi Baby Spa dengan Pola Tidur pada Bayi Usia 6-12 bulan di Klinik Almawadah 2 Day Care Kabupaten Batang
Authors: Prajayanti Hilda , Baroroh Ida , Artanti Swasti 
Published: May 2020

Istirahat dan tidur yang tepat sama pentingnya dengan nutrisi yang baik dan latihan yang adekuat. Aktivitas tidur merupakan salah satu stimulasi bagi tumbuh dan kembang bayi (Perry et al, 2006). Indonesia cukup banyak bayi yang mengalami masalah tidur, yaitu sekitar 44,2% bayi mengalami gangguan tidur seperti sering terbangun di malam hari. Namun hampir atau bahkan lebih dari 72% orang tua tidak menganggap gangguan tidur pada bayi sebagai suatu masalah.Meskipun dianggap masalah mereka hanya menganggapnya sebagai masalah kecil. Padahal, masalah tidur dapat menganggu pertumbuhan bayi, menyebabkan fungsi imun rentan, dan mengganggu regulasi system endokrin. Baby spa merupakan perawatan spa tubuh pada bayi yang dapat dilakukan dengan dua cara, yaitu mandi berendam atau berenang dan pijat. Manfaat baby spa ini dapat memberikan rasa tenang, nyaman, dan segar. Hantaman air yang ditimbulkan dari air yang bergolak dapat memberi sensasi dan pijatan yang menghilangkan lelah, melancarkan peredaran darah dan menciptakan relaksasi.Klinik Almawadah 2 Day Care Batang merupakan salah satu klinik yang memberikan pelayanan pijat bayi maupun baby spa. Penelitian ini menggunkan jenis penelitian analitik adalah penelitian yang mencoba menggali bagaimana dan mengapa fenomena kesehatan terjadi. Kemudian melakukan dinamika korelasi antara fenomena atau antara faktor resiko dengan efek. Yang dimaksud efek adalah suatu akibat dari adanya faktor resiko, sedangkan faktor resiko adalah suatu fenomena yang mengakibatkan terjadinya efek (pengaruh) (Notoatmodjo, 2012). Rancangan penelitian yang digunakan adalah cross sectional yang menekankan pada waktu pengukuran atau observasi data variable independen dan dependen hanya satu kali pada satu itu. Dari hasil penelitian mengenai hubungan antara baby spa dengan kualitas tidur bayi usia 6-12 bulan di Almawadah 2 DayCare Denasri Kulon Kabupaten Batang sebagai berikut: Sebagian besar Pendidikan Ibu SMA yang melakukan baby spa bayinya secara rutin, Sebagian besar bayi tidur nyenyak setelah dilakukan baby spa dan Ada hubungan antara baby spa dengan kualitas tidur.
ANALISIS FAKTOR MEMPENGARUHI LABA BERSIH PERUSAHAAN ASURANSI PT JASA RAHARJA (PERSERO)
Authors: Riftiasari Dinar , Sugiarti Sugiarti 
Published: May 2020

PT Jasa Raharja (Persero) adalah BUMN yang mengelola asuransi kecelakaan lalu lintas dengan menghimpun dana bersumber dari pendapatan premi, investasi kemudian menyalurkan dengan klaim. Tujuan Penelitian menganalisis pendapatan premi, hasil investasi, beban klaim terhadap laba bersih menggunakan korelasi secara parsial, determinasi dan regresi linier berganda. Penelitian menggunakan metode kuantitatif. Teknik analisa regresi linier berganda menggunakan software IBM SPSS 21. Data sekunder keuangan PT Jasa Raharja (persero) 2009-2017. Hasil penelitian uji koefisien korelasi secara parsial diperoleh pendapatan premi dan hasil investasi memiliki hubungan signifikan terhadap laba bersih sebesar 0,916 dan 0,844 hubungan sangat kuat dan searah, beban klaim terhadap laba bersih tidak terdapat hubungan secara parsial, secara simultan pendapatan premi, hasil investasi, dan beban klaim hubungan sangat kuat dan searah sebesar 0,994. Hasil uji koefisien determinasi menunjukkan pengaruh yang signifikan sebesar 98,8% dan sisanya 1,2% dipengaruhi oleh faktor lain. Persamaan regresi berganda yang terbentuk Y=3.409+1.603X1+ 0.257X2–1.021 X3
The Warrior Women of Islam
Authors: Kruk Remke 
Published: May 2020

Colloquial Arabic storytelling is most commonly associated with The Thousand and One Nights. But few people are aware of a much larger corpus of narrative texts known as popular epic. These heroic romantic tales, originating in the Middle Ages, form vast cycles of adventure stories whose most remarkable feature is their portrayal of powerful and memorable women. Wildly appreciated by medieval audiences, and spread by professional storytellers throughout the cities of the Muslim world, these fictions were printed and reprinted over the centuries and comprise a vital part of Arab culture. Yet virtually none are available in translation, and so remain almost unknown to a non-Arab public. Remke Kruk at last makes these neglected romances available to a Western audience. She recounts the story of Princess Dhat al-Himma, brave and undefeated leader of the Muslim army in its wars against the Byzantines; of Ghamra, brought up as a boy to become a fearless leader of men; and of cool-headed Qannasa, raiding from her mountain fortress to capture and seduce her enemies before putting them pitilessly to the sword.
The Warrior Women of Islam puts a bold new complexion on gender roles and the wider perception of women in the Middle East.
The End of Empire in Uganda
Authors: Mawby Spencer 
Published: May 2020

The negative legacy of the British empire is often thought of in terms of war and economic exploitation, while the positive contribution is associated with the establishment of good governance and effective, modern institutions. In this new analysis of the end of empire in Uganda, Spencer Mawby challenges these preconceptions by explaining the many difficulties which arose when the British attempted to impose western institutional models on Ugandan society.
Ranging from international institutions, including the Commonwealth, to state organisations, like the parliament and army, and to civic institutions such as trade unions, the press and the Anglican church, Mawby uncovers a wealth of new material about the way in which the British sought to consolidate their influence in the years prior to independence. The book also investigates how Ugandans responded to institutional reform and innovation both before and after independence, and in doing so sheds new light on the emergence of the notorious military dictatorship of Idi Amin. By unpicking historical orthodoxies about 20th-century imperial history, this institutional history of the end of empire and the early years of independence offers an opportunity to think afresh about the nature of the colonial impact on Africa and the development of authoritarian rule on the continent.
Hegel's Political Aesthetics
Authors: Bird-Pollan Stefan , Marchenkov Vladimir 
Published: May 2020

What is the role of art in modern society? To what extent are the beautiful and the morally good intertwined? Hegel's Political Aesthetics explores Hegel’s take on these ever-relevant philosophical questions and investigates three key themes: art’s contribution to modern ethical life, the loss of art’s authority in modern ethical life and ways of thinking beyond Hegel’s analysis of art’s role in society. The aesthetic is explored through the lens of German Idealism from Kant to Hegel, ultimately placing ethics and morality at the forefront of this debate.
The authors explore Hegel’s take on Kant’s conception by historicizing what it means to be responsible to others, which for Hegel means being free within the norms of society, within what he calls ethical life. As a set of concrete social arrangements designed for finite human beings, however, ethical life falls short of actualizing freedom absolutely.
The themes in this volume are motivated by a central ambivalence in Hegel’s thinking about modernity. The question of freedom sits at the forefront of this text, alongside the relation between art and the spirit. This book will be of particular interest to philosophers of aesthetics, politics and ethics.
The Theatre of Christopher Durang
Authors: Chirico Miriam M. 
Published: May 2020

The Theatre of Christopher Durang documents and analyses the major plays and productions of one of America’s significant contemporary playwrights who has contributed much to the American stage by his provocative works. It covers both his full-length and one-act plays, from his early success of Sister Mary Ignatius Explains it All For You (1974) to his most recent Tony-Award winning play, Vanya and Sonia and Masha and Spike (2012). Durang has given an original theatrical voice to American theatre by writing comedies that are irreverent and shocking, yet profoundly draw a connection between fear and laughter. This book, the first to provide an in-depth analysis of his plays, examines Durang’s use of specific comedic genres such as black comedy, satire, and farce as the means to explore American social malaise. Placing Durang within a tradition of Theater of the Absurd, the author incorporates comedic theory to examine how laughter in performance can dissolve hierarchies and subvert social conventions.
This volume provides the first comprehensive examination of Durang’s works and incorporates comedic theory to examine how laughter in performance subverts social conventions and hierarchies. Through a clear, detailed discussion of the plays, Miriam Chirico considers Durang’s use of black comedy, satire, and parody to explode such topics as: western literature, religion, dysfunctional families, and American social malaise. Robert Combs and Jay Malarcher provide additional critical perspectives about Durang’s works, detailing his use of alienation techniques and locating his place within the American parodic tradition. The book also includes a warm introduction by Durang’s former student, Pulitzer Prize-winner, David Lindsay-Abaire. The Theatre of Christopher Durang, in demonstrating how Durang has shaped contemporary theatrical possibilities, offers a valuable guide for students of American drama and comedy.
Dancefloor-Driven Literature
Authors: Morrison Simon A. 
Published: May 2020

Almost as soon as “club culture” took hold – during the UK’s Second Summer of Love in 1988 – its socio-political impact became clear, with journalists, filmmakers, and authors all keen to use this cultural context as source material for their texts. This book uses that electronic music subculture as a route into an analysis of these cultural representations of a music scene: both why such artefacts appear and what function they serve.
The book conceives of a new literary genre to accommodate these stories born of the dancefloor – “Dancefloor-Driven Literature.” Using interviews with Irvine Welsh, author of Trainspotting (1994), alongside other Dancefloor-Driven authors Nicholas Blincoe and Jeff Noon as case studies, the book analyzes three separate ways writers draw on electronic music in their fictions, interrogating that very particular intermedial intersection between the sonic and the linguistic. It explores how such authors write about something so subterranean as the nightclub scene, and analyses what specifically literary techniques they deploy to write lucidly and fluidly about the metronomic beat of electronic music, and the chemical accelerant that further alters that relationship.
Vorinostat in the acute neuroinflammatory form of X‐linked adrenoleukodystrophy
Authors: Zierfuss Bettina , Weinhofer Isabelle , Kühl Jörn‐Sven , Köhler Wolfgang , Bley Annette , Zauner Katharina , Binder Johannes , Martinović Ksenija , Seiser Christian , Hertzberg Christoph , Kemp Stephan , Egger Gerda , Leitner Gerda , Bauer Jan , Wiesinger Christoph , Kunze Markus , Forss‐Petter Sonja , Berger Johannes 
Published: May 2020

AbstractObjectiveTo identify a pharmacological compound targeting macrophages, the most affected immune cells in inflammatory X‐linked adrenoleukodystrophy (cerebral X‐ALD) caused by ABCD1 mutations and involved in the success of hematopoietic stem cell transplantation and gene therapy.MethodsA comparative database analysis elucidated the epigenetic repressing mechanism of the related ABCD2 gene in macrophages and identified the histone deacetylase (HDAC) inhibitor Vorinostat as a compound to induce ABCD2 in these cells to compensate for ABCD1 deficiency. In these cells, we investigated ABCD2 and pro‐inflammatory gene expression, restoration of defective peroxisomal β‐oxidation activity, accumulation of very long‐chain fatty acids (VLCFAs) and their differentiation status. We investigated ABCD2 and pro‐inflammatory gene expression, restoration of defective peroxisomal ß‐oxidation activity, accumulation of very long‐chain fatty acids (VLCFA) and differentiation status. Three advanced cerebral X‐ALD patients received Vorinostat and CSF and MRI diagnostics was carried out in one patient after 80 days of treatment.ResultsVorinostat improved the metabolic defects in X‐ALD macrophages by stimulating ABCD2 expression, peroxisomal ß‐oxidation, and ameliorating VLCFA accumulation. Vorinostat interfered with pro‐inflammatory skewing of X‐ALD macrophages by correcting IL12B expression and further reducing monocyte differentiation. Vorinostat normalized the albumin and immunoglobulin CSF‐serum ratios, but not gadolinium enhancement upon 80 days of treatment.InterpretationThe beneficial effects of HDAC inhibitors on macrophages in X‐ALD and the improvement of the blood‐CSF/blood‐brain barrier are encouraging for future investigations. In contrast with Vorinostat, less toxic macrophage‐specific HDAC inhibitors might improve also the clinical state of X‐ALD patients with advanced inflammatory demyelination.
A novel patient with White–Sutton syndrome refines the mutational and clinical repertoire of the POGZ‐related phenotype and suggests further observations
Authors: Pascolini Giulia , Agolini Emanuele , Fleischer Nicole , Gulotta Elisa , Cesario Claudia , D'Elia Gemma , Novelli Antonio , Majore Silvia , Grammatico Paola 
Published: May 2020

AbstractA rare developmental delay (DD)/intellectual disability (ID) syndrome with craniofacial dysmorphisms and autistic features, termed White–Sutton syndrome (WHSUS, MIM#614787), has been recently described, identifying truncating mutations in the chromatin regulator POGZ (KIAA0461, MIM#614787). We describe a further WHSUS patient harboring a novel nonsense de novo POGZ variant, which afflicts a protein domain with transposase activity less frequently impacted by mutational events (DDE domain). This patient displays additional physical and behavioral features, these latter mimicking Smith–Magenis syndrome (SMS, MIM#182290). Considering sleep–wake cycle anomalies and abnormal behavior manifested by this boy, we reinforced the clinical resemblance between WHSUS and SMS, being both chromatinopathies. In addition, using the DeepGestalt technology, we identified a different facial overlap between WHSUS patients with mutations in the DDE domain (Group 1) and individuals harboring variants in other protein domains/regions (Group 2). This report further delineates the clinical and molecular repertoire of the POGZ‐related phenotype, adding a novel patient with uncommon clinical and behavioral features and provides the first computer‐aided facial study of WHSUS patients.
Association between glioblastoma cell‐derived vessels and poor prognosis of the patients
Authors: Mei Xin , Chen Yin‐Sheng , Zhang Qing‐Ping , Chen Fu‐Rong , Xi Shao‐Yan , Long Ya‐Kang , Zhang Ji , Cai Hai‐Ping , Ke Chao , Wang Jing , Chen Zhong‐Ping 
Published: May 2020

AbstractBackgroundVessels with different microcirculation patterns are required for glioblastoma (GBM) growth. However, details of the microcirculation patterns in GBM remain unclear. Here, we examined the microcirculation patterns of GBM and analyzed their roles in patient prognosis together with two well‐known GMB prognosis factors (O6‐methylguanine DNA methyltransferase [MGMT] promoter methylation status and isocitrate dehydrogenase [IDH] mutations).MethodsEighty GBM clinical specimens were collected from patients diagnosed between January 2000 and December 2012. The microcirculation patterns, including endothelium‐dependent vessels (EDVs), extracellular matrix‐dependent vessels (ECMDVs), GBM cell‐derived vessels (GDVs), and mosaic vessels (MVs), were evaluated by immunohistochemistry (IHC) and immunofluorescence (IF) staining in both GBM clinical specimens and xenograft tissues. Vascular density assessments and three‐dimensional reconstruction were performed. MGMT promoter methylation status was determined by methylation‐specific PCR, and IDH1/2 mutations were detected by Sanger sequencing. The relationship between the microcirculation patterns and patient prognosis was analyzed by Kaplan‐Meier method.ResultsAll 4 microcirculation patterns were observed in both GBM clinical specimens and xenograft tissues. EDVs were detected in all tissue samples, while the other three patterns were observed in a small number of tissue samples (ECMDVs in 27.5%, GDVs in 43.8%, and MVs in 52.5% tissue samples). GDV‐positive patients had a median survival of 9.56 months versus 13.60 months for GDV‐negative patients (P = 0.015). In MGMT promoter‐methylated cohort, GDV‐positive patients had a median survival of 6.76 months versus 14.23 months for GDV‐negative patients (P = 0.022).ConclusionGDVs might be a negative predictor for the survival of GBM patients, even in those with MGMT promoter methylation.
Helices on Interdomain Interface Couple Catalysis in the ATPPase Domain with Allostery in Plasmodium falciparum GMP Synthetase
Authors: Shivakumaraswamy Santosh , Pandey Nivedita , Ballut Lionel , Violot Sébastien , Aghajari Nushin , Balaram Hemalatha 
Published: May 2020

AbstractGMP synthetase catalyses the conversion of XMP to GMP through a series of reactions that include hydrolysis of Gln to generate ammonia in the glutamine amidotransferase (GATase) domain, activation of XMP to adenyl‐XMP intermediate in the ATP pyrophosphatase (ATPPase) domain and reaction of ammonia with the intermediate to generate GMP. The functioning of GMP synthetases entails bidirectional domain crosstalk, which leads to allosteric activation of the GATase domain, synchronization of catalytic events and tunnelling of ammonia. Herein, we have taken recourse to the analysis of structures of GMP synthetases, site‐directed mutagenesis and steady‐state and transient kinetics on the Plasmodium falciparum enzyme to decipher the molecular basis of catalysis in the ATPPase domain and domain crosstalk. Our results suggest an arrangement at the interdomain interface, of helices with residues that play roles in ATPPase catalysis as well as domain crosstalk enabling the coupling of ATPPase catalysis with GATase activation. Overall, the study enhances our understanding of GMP synthetases, which are drug targets in many infectious pathogens.
A Step toward Molecular Evolution of RNA: Ribose Binds to Prebiotic Fatty Acid Membranes, and Nucleosides Bind Better than Individual Bases Do
Authors: Xue Mengjun , Black Roy A. , Cornell Caitlin E. , Drobny Gary P. , Keller Sarah L. 
Published: May 2020

AbstractA major challenge in understanding how biological cells arose on the early Earth is explaining how RNA and membranes originally colocalized. We propose that the building blocks of RNA (nucleobases and ribose) bound to self‐assembled prebiotic membranes. We have previously demonstrated that the bases bind to membranes composed of a prebiotic fatty acid, but evidence for the binding of sugars has remained a technical challenge. Here, we used pulsed‐field gradient NMR spectroscopy to demonstrate that ribose and other sugars bind to membranes of decanoic acid. Moreover, the binding of some bases is strongly enhanced when they are linked to ribose to form a nucleoside or – with the addition of phosphate – a nucleotide. This enhanced binding could have played a role in the molecular evolution leading to the production of RNA.
A Multilevel investigation into the effect of cultural distance on bilateral trade: The roles of product type and uncertainty avoidance
Authors: Wang Ying , Yang Zhiyong , Yasar Mahmut 
Published: May 2020

AbstractPrevious research shows mixed findings about how cultural distance may affect bilateral trade. To reconcile the mixed findings, we examine how key moderators at both the country‐pair level (product type) and the country level (uncertainty avoidance) affect the magnitude of the effect of cultural distance on bilateral trade. Using trade data on electronic products from 90 nations during 2008–2 014, we show that cultural distance in general has a negative impact on bilateral trade. However, the effect is more pronounced when the trade is on experience (versus search) products, or if the importing country is low (versus high) in uncertainty avoidance. Apart from its moderating effect, experience (versus search) product also has a negative main effect on bilateral trade, but its impact is stronger for countries low (versus high) in uncertainty avoidance.
Copper‐Catalyzed Carbocyclization of Silyl Enol Ether Tethered Ynamides for Efficient and Practical Synthesis of 2‐Azabicyclo[3.2.0] Compounds†
Authors: Huang En‐He , Zhang Zhi‐Xin , Ye Si‐Han , Chen Yang‐Bo , Luo Wen‐Feng , Qian Peng‐Cheng , Ye Long‐Wu 
Published: May 2020

Summary of main observation and conclusionAn efficient copper‐catalyzed carbocyclization of silyl enol ether tethered ynamides has been developed, allowing rapid and practical construction of diverse 2‐azabicyclo[3.2.0] compounds in generally good to excellent yields with broad substrate scope under mild reaction conditions. Importantly, this protocol not only constitutes a rare example of non‐noble metal‐catalyzed alkyne carbocyclization, but also represents a rare cyclization on the β‐position of π‐tethered ynamides. The possibility of asymmetric carbocyclization via kinetic resolution also emerges.
On water‐use efficiency, boundary functions, and yield gaps: French and Schultz insight and legacy
Authors: Sadras Victor O. 
Published: May 2020

AbstractThis article is part of a series of brief commentaries to highlight papers that have resulted in important and distinctly new perspectives in crop science. Here, we outline a series of two papers by French and Schultz (F&S) on water use efficiency of wheat (Triticum aestivum L.) published in 1984. The insight of F&S was not to draw a regression line across their yield‐evapotranspiration data. Instead they saw an upper limit of 20 kg ha−1 mm−1 that, less than a decade after publication, was widely used by Australian farmers to benchmark their crops and identify causes of yield gaps. Over the last two decades, F&S‐type benchmarks have been expanded beyond wheat and beyond Australia to include sunflower (Helianthus annuus L.) in Argentina, maize (Zea mays L.) and wheat in the United States and China, and millet [Pennisetum glaucum (L.) R. Br.] in West Africa, among others. More recently, the concept of yield gap analysis based on a upper limit of yield per unit resource uptake has been successfully extrapolated to N. The N uptake per millimeter of water required to meet the water‐limited yield potential (0.65 kg N ha−1 mm−1 under their original conditions) is a hidden insight in the work of French and Schultz; it has been recently rediscovered in the context of crop improvement, co‐limitation theory, and drought‐induced N deficit. Perhaps more deeply, French and Schultz shifted farmers mindset from the mildly fatalistic idea of “drought” to the notion that many other factors were typically limiting crop yield, and the quantitative challenge of attaining a plausible benchmark.