bluuebunny/crossref_metadata_2025_split huggingface dataset:
Big Data for Finite Population Inference: Applying Quasi-Random Approaches to Naturalistic Driving Data Using Bayesian Additive Regression Trees
Authors: Rafei Ali , Flannagan Carol A C , Elliott Michael R 
Published: December 2019

AbstractBig Data are a “big challenge” for finite population inference. Lack of control over data-generating processes by researchers in the absence of a known random selection mechanism may lead to biased estimates. Further, larger sample sizes increase the relative contribution of selection bias to squared or absolute error. One approach to mitigate this issue is to treat Big Data as a random sample and estimate the pseudo-inclusion probabilities through a benchmark survey with a set of relevant auxiliary variables common to the Big Data. Since the true propensity model is usually unknown, and Big Data tend to be poor in such variables that fully govern the selection mechanism, the use of flexible non-parametric models seems to be essential. Traditionally, a weighted logistic model is recommended to account for the sampling weights in the benchmark survey when estimating the propensity scores. However, handling weights is a hurdle when seeking a broader range of predictive methods. To further protect against model misspecification, we propose using an alternative pseudo-weighting approach that allows us to fit more flexible modern predictive tools such as Bayesian Additive Regression Trees (BART), which automatically detect non-linear associations as well as high-order interactions. In addition, the posterior predictive distribution generated by BART makes it easier to quantify the uncertainty due to pseudo-weighting. Our simulation findings reveal further reduction in bias by our approach compared with conventional propensity adjustment method when the true model is unknown. Finally, we apply our method to the naturalistic driving data from the Safety Pilot Model Deployment using the National Household Travel Survey as a benchmark.
The protein kinase complex CBL10–CIPK8–SOS1 functions in Arabidopsis to regulate salt tolerance
Authors: Yin Xiaochang , Xia Youquan , Xie Qing , Cao Yuxin , Wang Zhenyu , Hao Gangping , Song Jie , Zhou Yang , Jiang Xingyu 
Published: December 2019

Abstract
Salt tolerance in plants is mediated by Na+ extrusion from the cytosol by the plasma membrane Na+/H+ antiporter SOS1. This is activated in Arabidopsis root by the protein kinase complex SOS2–SOS3 and in Arabidopsis shoot by the protein kinase complex CBL10–SOS2, with SOS2 as a key node in the two pathways. The sos1 mutant is more sensitive than the sos2 mutant, suggesting that other partners may positively regulate SOS1 activity. Arabidopsis has 26 CIPK family proteins of which CIPK8 is the closest homolog to SOS2. It is hypothesized that CIPK8 can activate Na+ extrusion by SOS1 similarly to SOS2. The plasma membrane Na+/H+ exchange activity of transgenic yeast co-expressing CBL10, CIPK8, and SOS1 was higher than that of untransformed and SOS1 transgenic yeast, resulting in a lower Na+ accumulation and a better growth phenotype under salinity. However, CIPK8 could not interact with SOS3, and the co-expression of SOS3, CIPK8, and SOS1 in yeast did not confer a significant salt tolerance phenotype relative to SOS1 transgenic yeast. Interestingly, cipk8 displayed a slower Na+ efflux, a higher Na+ level, and a more sensitive phenotype than wild-type Arabidopsis, but grew better than sos2 under salinity stress. As expected, sos2cipk8 exhibited a more severe salt damage phenotype relative to cipk8 or sos2. Overexpression of CIPK8 in both cipk8 and sos2cipk8 attenuated the salt sensitivity phenotype. These results suggest that CIPK8-mediated activation of SOS1 is CBL10-dependent and SOS3-independent, indicating that CIPK8 and SOS2 activity in shoots is sufficient for regulating Arabidopsis salt tolerance.
Shared Care and Child Maintenance Policies in Nordic Countries
Authors: Hakovirta Mia , Eydal Guðný Björk 
Published: December 2019

Abstract
The Nordic welfare model is referred to as the dual earner/dual carer model, where the explicit policy goal is to promote the equal sharing of the responsibility of care for children and paid work among men and women. However, how does the dual earner/dual carer model apply to parents who do not live together but who share care, ie, both parents spending substantial time caring for and living with their child? In this article, we compare child maintenance policies in the five Nordic countries – Denmark, Finland, Iceland, Norway, and Sweden – as a means of interrogating how dual earner/carer ideals and realities play out for parents who share care but do not live together. The article makes a unique contribution to the knowledge of how the ideology and practice of shared care is implemented across Nordic countries. Based on vignette data collected in 2017, we show that despite an emphasis on the dual earner/dual carer model, in most cases, Finland and Iceland still refer to a male breadwinner model in their maintenance policies and do not recognise shared care arrangements as matters needing particular policy consideration. Sweden, Norway, and Denmark, on the other hand, recognise shared care in their laws and substantially reduce child maintenance payments in cases of shared care.
N-acetylcysteine reduces amphotericin B deoxycholate nephrotoxicity and improves the outcome of murine cryptococcosis
Authors: Magalhães Thais Furtado Ferreira , Costa Marliete Carvalho , Holanda Rodrigo Assunção , Ferreira Gabriela Freitas , Carvalho Vanessa Silva Dutra , Freitas Gustavo Jose Cota , Ribeiro Noelly Queiroz , Emídio Elúzia Castro Peres , Carmo Paulo Henrique Fonseca , de Brito Camila Bernardo , de Souza Daniele Glória , Rocha Cláudia Emanuela Viana , Paixão Tatiane Alves , de Resende-Stoianoff Maria Aparecida , Santos Daniel Assis 
Published: December 2019

AbstractCryptococcosis is a life-threatening fungal infection, and its current treatment is toxic and subject to resistance. Drug repurposing represents an interesting approach to find drugs to reduce the toxicity of antifungals. In this study, we evaluated the combination of N-acetylcysteine (NAC) with amphotericin B (AMB) for the treatment of cryptococcosis. We examined the effects of NAC on fungal morphophysiology and on the macrophage fungicidal activity 3 and 24 hours post inoculation. The therapeutic effects of NAC combination with AMB were investigated in a murine model with daily treatments regimens. NAC alone reduced the oxidative burst generated by AMB in yeast cells, but did not inhibit fungal growth. The combination NAC + AMB decreased capsule size, zeta potential, superoxide dismutase activity and lipid peroxidation. In macrophage assays, NAC + AMB did not influence the phagocytosis, but induced fungal killing with different levels of oxidative bursts when compared to AMB alone: there was an increased reactive oxygen species (ROS) after 3 hours and reduced levels after 24 hours. By contrast, ROS remained elevated when AMB was tested alone, demonstrating that NAC reduced AMB oxidative effects without influencing its antifungal activity. Uninfected mice treated with NAC + AMB had lower concentrations of serum creatinine and glutamate-pyruvate transaminase in comparison to AMB. The combination of NAC + AMB was far better than AMB alone in increasing survival and reducing morbidity in murine-induced cryptococcosis, leading to reduced fungal burden in lungs and brain and also lower concentrations of pro-inflammatory cytokines in the lungs. In conclusion, NAC + AMB may represent an alternative adjuvant for the treatment of cryptococcosis.
Resilient habitability of nearby exoplanet systems
Authors: Kokaia Giorgi , Davies Melvyn B , Mustill Alexander J 
Published: December 2019

ABSTRACT
We investigate the possibility of finding Earth-like planets in the habitable zone of 34 nearby FGK-dwarfs, each known to host one giant planet exterior to their habitable zone detected by RV. First we simulate the dynamics of the planetary systems in their present day configurations and determine the fraction of stable planetary orbits within their habitable zones. Then, we postulate that the eccentricity of the giant planet is a result of an instability in their past during which one or more other planets were ejected from the system. We simulate these scenarios and investigate whether planets orbiting in the habitable zone survive the instability. Explicitly we determine the fraction of test particles, originally found in the habitable zone, which remain in the habitable zone today. We label this fraction the resilient habitability of a system. We find that for most systems the probability of planets existing [or surviving] on stable orbits in the habitable zone becomes significantly smaller when we include a phase of instability in their history. We present a list of candidate systems with high resilient habitability for future observations. These are: HD 95872, HD 154345, HD 102843, HD 25015, GJ 328, HD 6718, and HD 150706. The known planets in the last two systems have large observational uncertainties on their eccentricities, which propagate into large uncertainties on their resilient habitability. Further observational constraints of these two eccentricities will allow us to better constrain the survivability of Earth-like planets in these systems.
H0LiCOW XII. Lens mass model of WFI2033 − 4723 and blind measurement of its time-delay distance and H0
Authors: Rusu Cristian E , Wong Kenneth C , Bonvin Vivien , Sluse Dominique , Suyu Sherry H , Fassnacht Christopher D , Chan James H H , Hilbert Stefan , Auger Matthew W , Sonnenfeld Alessandro , Birrer Simon , Courbin Frederic , Treu Tommaso , Chen Geoff C-F , Halkola Aleksi , Koopmans Léon V E , Marshall Philip J , Shajib Anowar J 
Published: December 2019

ABSTRACT
We present the lens mass model of the quadruply-imaged gravitationally lensed quasar WFI2033 − 4723, and perform a blind cosmographical analysis based on this system. Our analysis combines (1) time-delay measurements from 14 yr of data obtained by the COSmological MOnitoring of GRAvItational Lenses (COSMOGRAIL) collaboration, (2) high-resolution Hubble Space Telescope imaging, (3) a measurement of the velocity dispersion of the lens galaxy based on ESO-MUSE data, and (4) multi-band, wide-field imaging and spectroscopy characterizing the lens environment. We account for all known sources of systematics, including the influence of nearby perturbers and complex line-of-sight structure, as well as the parametrization of the light and mass profiles of the lensing galaxy. After unblinding, we determine the effective time-delay distance to be $4784_{-248}^{+399}~\mathrm{Mpc}$, an average precision of $6.6{{\ \rm per\ cent}}$. This translates to a Hubble constant $H_{0} = 71.6_{-4.9}^{+3.8}~\mathrm{km~s^{-1}~Mpc^{-1}}$, assuming a flat ΛCDM cosmology with a uniform prior on Ωm in the range [0.05, 0.5]. This work is part of the H0 Lenses in COSMOGRAIL’s Wellspring (H0LiCOW) collaboration, and the full time-delay cosmography results from a total of six strongly lensed systems are presented in a companion paper (H0LiCOW XIII).
Understanding the coexistence of spin-up and spin-down behaviours in long-period X-ray pulsars
Authors: Wang W , Tong H 
Published: December 2019

ABSTRACT
Assuming wind-fed accretion magnetars in long-period X-ray pulsars, we calculated the rotational evolution of neutron stars. Our calculations considered the effects of magnetic field decay in magnetars. The results show that wind-fed accretion magnetars can evolve to long-period X-ray pulsars with a spin period much longer than 1000 s. The spin-down trend observed in 4U 2206+54-like sources is expected when young X-ray binary systems are on the way to their equilibrium period. Detailed calculations showed that the spin-down may be affected by accretion with outflows or accretion while spinning down. Due to magnetic field decay in magnetars, wind-fed accretion magnetars will have a decreasing equilibrium period for a constant mass accretion rate. For 2S 0114+65, the spin-up rate due to magnetic field decay is one order of magnitude smaller than observations. The spin-up rate of 2S 0114+65 may be attributed to the formation of a transient disc during wind accretion. The slowest X-ray pulsar AX J1910.7+0917 would be a link source between 4U 2206+54 and 2S 0114+65.
Feasibility of Parent Coaching of Music Interventions for Children With Autism Spectrum Disorder
Authors: Hernandez-Ruiz Eugenia 
Published: December 2019

AbstractParent-mediated interventions for children with autism spectrum disorder (ASD) have elicited emerging interest among music therapists. A conceptual framework (reported elsewhere) delineated the incorporation of music to an established parent coaching model (Parent-Early Start Denver Model [P-ESDM];). The purpose of this study was to explore the feasibility of adapting the P-ESDM to a music-based parent coaching model. An alternating treatments design with a parent–child dyad was implemented, with music and non-music conditions in each treatment session. Behavioral video analysis of parental verbal and non-verbal responsiveness, child joint attention and verbal behaviors, and parent and therapist adherence to treatment provided quantitative data. A semi-structured follow-up interview with a parent addressed concerns, preferences, and suggestions for improvement. Parental verbal responsiveness seemed lower during the music condition, but non-verbal responsiveness increased notably during the music condition. Parent adherence to treatment was achieved in the sixth session. Child receptive joint attention increased in the music condition only, and initiating joint attention was higher in most sessions during the music condition. Parental comfort with the music did not seem ideal with the brief time allotted to training despite familiarity with the music. Music-based parent coaching to enhance social communication of preschoolers with ASD seems feasible. This study provides initial support to a conceptual framework of parent coaching of music interventions. Further research should investigate other methods to teach the music, alternative session schedules, and more precise measures of parental responsiveness.
Native elongation transcript sequencing reveals temperature dependent dynamics of nascent RNAPII transcription in Arabidopsis
Authors: Kindgren Peter , Ivanov Maxim , Marquardt Sebastian 
Published: December 2019

Abstract
Temperature profoundly affects the kinetics of biochemical reactions, yet how large molecular complexes such as the transcription machinery accommodate changing temperatures to maintain cellular function is poorly understood. Here, we developed plant native elongating transcripts sequencing (plaNET-seq) to profile genome-wide nascent RNA polymerase II (RNAPII) transcription during the cold-response of Arabidopsis thaliana with single-nucleotide resolution. Combined with temporal resolution, these data revealed transient genome-wide reprogramming of nascent RNAPII transcription during cold, including characteristics of RNAPII elongation and thousands of non-coding transcripts connected to gene expression. Our results suggest a role for promoter–proximal RNAPII stalling in predisposing genes for transcriptional activation during plant–environment interactions. At gene 3′-ends, cold initially facilitated transcriptional termination by limiting the distance of read-through transcription. Within gene bodies, cold reduced the kinetics of co-transcriptional splicing leading to increased intragenic stalling. Our data resolved multiple distinct mechanisms by which temperature transiently altered the dynamics of nascent RNAPII transcription and associated RNA processing, illustrating potential biotechnological solutions and future focus areas to promote food security in the context of a changing climate.
Systematic review: measurement properties of patient-reported outcome measures evaluated with childhood brain tumor survivors or other acquired brain injury
Authors: Bull Kim S , Hornsey Samantha , Kennedy Colin R , Darlington Anne-Sophie E , Grootenhuis Martha A , Hargrave Darren , Liossi Christina , Shepherd Jonathan P , Walker David A , Morris Christopher 
Published: December 2019

Abstract

Background
Survivors of childhood brain tumors or other acquired brain injury (ABI) are at risk of poor health-related quality of life (HRQoL); its valid and reliable assessment is essential to evaluate the effect of their illness on their lives. The aim of this review was to critically appraise psychometric properties of patient-reported outcome measures (PROMs) of HRQoL for these children, to be able to make informed decisions about the most suitable PROM for use in clinical practice.

Methods
We searched MEDLINE, EMBASE, and PsycINFO for studies evaluating measurement properties of HRQoL PROMs in children treated for brain tumors or other ABI. Methodological quality of relevant studies was evaluated using the consensus-based standards for the selection of health status measurement instruments checklist.

Results
Eight papers reported measurement properties of 4 questionnaires: Health Utilities Index (HUI), PedsQL Core and Brain Tumor Modules, and Child and Family Follow-up Survey (CFFS). Only the CFFS had evidence of content and structural validity. It also demonstrated good internal consistency, whereas both PedsQL modules had conflicting evidence regarding this. Conflicting evidence regarding test-retest reliability was reported for the HUI and PedsQL Core Module only. Evidence of measurement error/precision was favorable for HUI and CFFS and absent for both PedsQL modules. All 4 PROMs had some evidence of construct validity/hypothesis testing but no evidence of responsiveness to change.

Conclusions
Valid and reliable assessment is essential to evaluate impact of ABI on young lives. However, measurement properties of PROMs evaluating HRQoL appropriate for this population require further evaluation, specifically construct validity, internal consistency, and responsiveness to change.
Neurobiological Basis of Migraine
Authors: Holland Philip R. , Hoffmann Jan , Goadsby Peter J. 
Published: December 2019

Abstract
Migraine is the most common disabling primary headache globally. Attacks often present with unilateral throbbing headache and an array of associated symptoms, including, nausea, multisensory hypersensitivity, and marked fatigue. The diverse symptomatology highlights the complexity of migraine as a whole nervous system disorder involving somatosensory, autonomic, endocrine, and arousal networks. While attempts to describe the entirety of migraine are complex and daunting, this chapter focuses on recent advances in the understanding of its pathophysiology and treatment. The chapter focuses on the underlying neuroanatomical basis for migraine-related headache and associated symptomatology and discusses key clinical and preclinical findings that indicate that migraine likely results from dysfunctional homeostatic mechanisms. Whereby abnormal central nervous system responses to extrinsic and intrinsic cues may lead to increased attack susceptibility. Finally, the chapter considers the recent translational success of targeted calcitonin gene-related peptide and serotonin 1F receptor (5-HT1F) modulation for migraine.
Bonhoeffer and Political Life
Authors: Plant Stephen J. 
Published: December 2019

Abstract
This chapter begins by describing some of the influences that shaped Bonhoeffer’s political views, narrowly construed, and the central role of Martin Luther’s thought in guiding the direction of those parts of his theology that connect with political life. The chapter continues by exploring how Bonhoeffer attempted to think with and through these sources about the duties and responsibilities of governments and citizens, of the Church, and of the individual Christian in response to the Church struggle and the policies of the Third Reich. What evolved was a reworking of the orders of creation and preservation, a subtle ecology of temporal and spiritual authority under God, and an understanding of reality understood through the incarnation of Christ. This theology funded a steadfast conviction that the Church can and must speak God’s Word to the world, even to the point of standing in the place of the victims of political oppression.
Bonhoeffer and Contemporary Philosophy
Authors: Zimmermann Jens 
Published: December 2019

Abstract
How does Bonhoeffer view the relation between philosophy and theology? To what extent is his own theology shaped by philosophical thought? Moreover, how do the major themes of Bonhoeffer’s theological work relate to concerns of contemporary philosophy? These are the questions addressed in this chapter. Given Bonhoeffer’s training in and proclivity to continental philosophy, we will focus on the phenomenological tradition in general and on personalism and hermeneutics in particular. As it turns out, Bonhoeffer’s Christological starting point in the incarnation offers important insights for contemporary ethical philosophy (Lévinas) and postmodern hermeneutical thinkers (Derrida, Kearney, Caputo, and Vattimo).
Assessment of Attachment in Infancy and Early Childhood
Authors: Boris Neil W. , Chesher Tessa , Wajda-Johnston Valerie A. 
Published: December 2019

Abstract
Attachment is a fundamental developmental domain in infancy and early childhood and no clinical assessment is complete without a comprehensive assessment of the young child’s key attachment relationships. This chapter uses the Circle of Security, a graphic representation of the hundreds of daily dyadic interactions that form the basis of attachment in early childhood, to help frame attachment theory. The importance of recognizing child and parent factors that might lead to disorganization of attachment in infancy and early childhood is emphasized and the history of research on forms of reactive attachment disorder is presented in the context of differential diagnosis. Key principles for attachment assessment are then reviewed and the tools that comprise comprehensive assessment of attachment in early childhood are presented, with an emphasis on tools used for assessment of parent–child interaction and those used to gather data on the parental state of mind regarding attachment. The chapter concludes with a case example that includes a discussion of treatment planning.
The Contribution of Developmentally Sensitive Measurement to Assessment of Disruptive Behavior in Young Children
Authors: Gray Sarah A. O. , Wakschlag Lauren S. 
Published: December 2019

AbstractThis chapter provides a review of developmentally informed assessments of disruptive behavior in young children. First, the definition of a “developmentally sensitive” approach to the assessment of disruptive behavior is presented. The chapter then provides a review of existing validated measures that assess disruptive behavior and clinical impairment in young children, considering specifically the assessments’ developmental specificity, clinical properties, and how they can be used. Finally, the importance of attending to context in the assessment of disruptive behavior in young children, including the interactional context (e.g., parent vs. nonparental, home vs. school), family and cultural contexts, and the context of developmental functioning, is highlighted. The chapter ends with a review of clinical implications and suggestions for future research to address gaps in the current knowledge base.