bluuebunny/crossref_metadata_2025_split huggingface dataset:
GeoCGNN: A Geometric-Information-Enhanced Crystal Graph Network for Property Predictions
Authors: Jiucheng Cheng , Dong Lifeng , Zhang Chunkai 
Published: December 2020

Abstract
Graph neural networks (GNNs) have been explored to search for novel crystal materials. But in previous works, geometric structure was not taken into consideration or incompletely. Here, we develop a geometric-information-enhanced crystal graph neural network (GeoCGNN) to predict properties of novel crystal materials. By considering the distance vector between each node and its neighbors, our model can learn full topologic and spatial geometric structure information. Furthermore, we incorporate an effective method based on the mixed basis functions to encode the geometric information into our model, which outperforms other CGNN methods in a variety of databases. As for predicting the formation energy, our model is 30.3%, 14.6% and 13% better than CGCNN, MEGNet and iCGCNN models, respectively. For band gap, our model outperforms respectively 27.6% and 15.2% than CGCNN and MEGNet. Also, we interpret the implied material properties of the learned graph vector in a visible way.
The association between Helicobacter pylori infection and food intolerance in western&nbsp;China
Authors: Liu Ying , Li Dongyu , Xiao Ning , Liu Yuping , Shuai Ping 
Published: December 2020

Abstract
IntroductionHelicobacter pylori (H. pylori) has been found to be associated with extragastrointestinal diseases while the studies on its association with food intolerance are rare. In our study, we tried to explore the relationship between H. pylori infection and food intolerance.MethodsWe retrospectively analyzed the physical examination data of 21,822 subjects from February 2014 to December 2018 in this study. H. pylori infection was determined by 13C urea breath test. The food specific IgG in serum were detected to assess the food tolerance status of egg, milk and wheat.ResultsThe total infection rate of H. pylori was 39.3% and the total food intolerance rates of egg, milk and wheat were 25.2%, 9.0% and 4.7%, respectively. The infection rate of H. pylori was higher in males than that in females, while the intolerance rates were lower in males than that in females. The infection rates of H. pylori increased with age except for people over sixty, while the intolerance rates decreased. In H. pylori positive group, the intolerance rates were lower than that in the H. pylori negative group. At the same level of food intolerance, the intolerance rates in H. pylori positive group were lower than that in H. pylori negative group. Multivariate Logistic regression analysis showed that H. pylori infection was negatively correlated with intolerance of egg, milk and wheat (OR value of egg 0.844–0.873, milk 0.741–0.751, wheat 0.762–0.801).ConclusionsH. pylori infection was negatively correlated with intolerance of egg, milk and wheat in Sichuan, western China.
Ability of artificial intelligence to detect T1 esophageal squamous cell carcinoma from endoscopic videos: supportive effects of real-time assistance
Authors: Shiroma Sho , Yoshio Toshiyuki , Kato Yusuke , Horie Yoshimasa , Namikawa Ken , Tokai Yoshitaka , Yoshimizu Shoichi , Horiuchi Yusuke , Ishiyama Akiyoshi , Hirasawa Toshiaki , Tsuchida Tomohiro , Akazawa Naoki , Akiyama Junichi , Tada Tomohiro , Fujisaki Junko 
Published: December 2020

Abstract
Diagnosis using artificial intelligence (AI) with deep learning could be useful in endoscopic examinations. We investigated the ability of AI to detect superficial esophageal squamous cell carcinoma (ESCC) from esophagogastroduodenoscopy (EGD) videos. We retrospectively collected 8428 EGD images of esophageal cancer to develop a convolutional neural network through deep learning. We evaluated the detection accuracy of the AI diagnosing system compared with that of 18 endoscopists. We used 144 EGD videos for the two validation sets. First, we used 64 EGD observation videos of ESCC using both white light imaging (WLI) and narrow-band imaging (NBI). We then evaluated the system using 80 EGD videos from 40 patients (20 with superficial ESCC and 20 with non-ESCC). In the first set, the AI system correctly diagnosed 100% ESCCs. In the second set, it correctly detected 85% (17/20) ESCCs. Of these, 75% (15/20) and 55% (11/22) were detected by WLI and NBI, and the positive predictive value was 36.7%. The endoscopists correctly detected 45% (25-70%) ESCCs. With AI real-time assistance, the sensitivities of the endoscopists were significantly improved without AI assistance (p<0.05). AI can detect superficial ESCC from EGD videos with high sensitivity and improve endoscopists’ detection of ESCC with real-time support.
Association of the Extent of Myocardial Ischemia with Outcomes in Patients with Suspected Coronary Artery Disease
Authors: Kato Takao , Momose Mitsuru , Uemura Yukari , Naya Masanao , Matsumoto Naoya , Hida Satoshi , Yamauchi Takao , Nakajima Takamoto , Suzuki Eriko , Inoko Moriaki , Tamaki Nagara 
Published: December 2020

Abstract
Background: There is an ongoing controversy regarding the necessity of single-photon emission computed tomography (SPECT) for patients with ischemic heart diseases after the publication of the results of the ISCHEMIA trial. We aimed to evaluate the association of the extent of myocardial ischemia with outcomes in patients with suspected coronary artery disease in Japan.Methods: From the data of 2780 patients with stable angina, who were enrolled prospectively between January 2006 and March 2008 in Japan and had undergone physician-referred non-invasive imaging tests, 1205 patients managed with SPECT were stratified by 10% myocardial ischemia. Major adverse cardiac events (MACEs), including death, myocardial infarction, hospitalization for heart failure, and late revascularization, were followed-up for 1 year. Results: Patients with ≥10% myocardial ischemia (n=173) were older than patients with <10% myocardial ischemia (n=1032) and had a significantly higher 1-year cumulative incidence of MACEs (9.1% vs. 1.2%, P<0.0001). After adjusting for confounders, the risk of ≥10% myocardial ischemia relative to <10% myocardial ischemia for MACEs remained significant (adjusted hazard ratio [95% confidence interval], 2.40 [1.09-5.26], P=0.029).Conclusion: The presence of ≥10% myocardial ischemia was significantly associated with the 1-year risk for MACEs in Japanese patients with suspected coronary artery disease.
Genetic Inconsistency Assessment and Selection Criteria of Bambara groundnut (Vigna subterranea L.Verdc.) Landraces for High Yield Revealed by Qualitative and Quantitative traits
Authors: Khan Md Mahmudul Hasan , Rafii Mohd Y. , Ramlee Shairul Izan , Jusoh Mashitah , Al-Mamun Md 
Published: December 2020

Abstract
As a crop for the new millennium Bambara groundnut (Vigna subterranea L. Verdc.) considered as leading legumes in the tropical regions due to its versatile advantages. The main intent of this study was to find out the high yielding potential genotypes and considering these genotypes to develop pure lines for commercial cultivation in Malaysia. Considering the 14 qualitative and 27 quantitative traits of fifteen landraces the variation and genetic parameters namely, variability, heritability, genetic advance, characters association, and cluster matrix were determined. ANOVA revealed significant variation for all the agronomic traits (except plant height). Among the accessions, highly significant differences (P ≤ 0.01) were found for almost all the traits excluding fifty percent flowering date, seed length, seed width. The 16 traits out of the 27 quantitative traits had a coefficient of variation (CV) ≥ 20%. A positive and intermediate to perfect highly significant association (r = 0.23 to 1.00; P < 0.00) was found between yield and its related traits. The trait dry seed weight per plant (g) had the highest GCV = 59.91% and PCV = 59.57% whereas the trait fresh pod weight (99.55%), dry seed weight (98.86%), and yield (98.10%) were highly heritable. The genetic advance recorded the highest for dry seed weight (122.01%) and lowest (3.97%) for plant height. To validate the genetic disparity, an unweighted pair-group produce with arithmetic mean (UPGMA), principal component analysis (PCA), and Hˊ-index was performed considering 27 quantitative traits. The constructed dendrogram showed five distinct groups of accessions. Genotypes G2, G3, and G9 from Group IV consider as promising lines which gave 70.05% higher mean yield compared to grand mean yield (1180 kg ha-1) with desirable traits. Group II had a maximum number of accessions while group III and group V had one of each. However, findings declared that the availability of genetic variance will be beneficial for this crop improvement and plant breeders to prefer desirable traits in V. subterranea L. Verdc. for further breeding purposes.
Curbing Adolescent Illicit Drug Use in Owerri Metropolis, Nigeria: A Public Perceptive
Authors: Ogu Udochukwu , Ezumah Nkoli , Odii Aloysius , Pamela Nkolika 
Published: December 2020

Abstract
Background: To reduce the rate of illicit drug use, the public has an important role to play, therefore how they perceive illicit drug use among youths must be ascertained. This study seeks to ascertain the public perception of strategies for curbing adolescent drug use.Methods: A descriptive cross-sectional research design was used for the study. The study adopted a mixed-method approach comprising quantitative and qualitative methods. The study population consisted of members of the public aged 18 years and above, residing in Owerri metropolis at the time of the study. A total of 10 communities were selected randomly in all: four communities from the 16 communities that make up Owerri West, five communities from the 18 communities that make up Owerri North and one community from the five communities that make up Owerri Municipal. A total of 16 respondents were purposively selected for in-depth interviews.Results: The quantitative findings show that 70.7% of respondents believe that the use of illicit drugs by adolescents can be controlled. The findings also show that one of the public’s perception to control adolescent drug use is to establish stringent anti-illicit drugs consumption laws/policies (20.4%) amongst others. The qualitative findings report that in order to curb the use of drugs by adolescents, the following activities and bodies need to be implored: health promotion, raising more awareness and sensitization campaigns, creation of remand homes for juveniles, the involvement of parents, school authorities and religious organizations and rehabilitation programmes. However, raising awareness, according to the study was reported as a reliable way of eliminating drug use among adolescents.Conclusion: To curb illicit drug use, proper funding of drug enforcement agencies, sensitization campaigns, strict laws on drug prescription, provision and use and health education etc. are very necessary for reducing adolescents’ illicit drug consumption.
Removal of Direct Yellow 50 From Aqueous Solutions Using Chitosan-ISO-Vanillin Derivatives Chelating Polymers
Authors: Alabbad Eman 
Published: December 2020

Abstract

Background Water contamination has increasingly become a significant problem affecting the welfare of living organisms perceived to be aquatic beneficiaries. The nature and origin of the contaminant always determines the purification techniques. The most common contaminants in wastewater include organic compounds such as dyes that must be eliminated to enhance water purity and safety.Result The results indicate that the removal of DY50 by the modified chitosan was affected by the solution pH, sorbent dosage, initial DY50 concentration, contact time, and temperature. The experimental data were fitted to the Langmuir, Freundlich, and Temkin isotherms, and Langmuir isotherm showed the best fit. The kinetic data were fitted to the pseudo-first-order and pseudo-second-order rate equations. The removal rate was 97.9% by chemisorption components after the three hours at about 0.05 g of sorbent dose and 100 ppm of the Direct Yellow 50 dye initial concentration. The adsorption behavior of the modified chitosan for the removal of DY50 was well-described using the pseudo-second-order kinetic model, Intraparticle diffusion analysis was also conducted. The thermodynamic properties such as free energy (∆G), enthalpy (∆H), and entropy (∆S), in addition to the intra-particle diffusion rate were similarly defined.Conclusion The pH, initial DY50 concentration, sorbent dosage, adsorption temperature, and contact time had a significant effect on the adsorption of DY50 by chitosan-iso-vanillin.
A Prospective Feasibility Study of a 1-mm bolus for Postmastectomy Radiotherapy
Authors: Kawamoto Terufumi , Shikama Naoto , Kurokawa Chie , Hara Naoya , Oshima Masaki , Sasai Keisuke 
Published: December 2020

Abstract
Background: The optimal chest wall bolus regimen for postmastectomy radiotherapy (PMRT) remains unknown. We aimed to prospectively evaluate the use of a 1-mm-thick daily tissue-equivalent bolus in patients who received PMRT using thermoluminescent dosimeters (TLDs) and skin toxicity assessment.Methods: Patients with a 1-mm-thick daily bolus during PMRT were prospectively enrolled at The Juntendo University Hospital. The surface dose was measured in vivo under the 1-mm-thick bolus on the chest wall. We assessed the acute skin toxicity weekly during PMRT, and 1, 2, 4, and 12 weeks after the completion of PMRT.Results: A total of 19 patients aged 32−79 years old received PMRT from July 2019 to January 2020. All patients completed the protocol treatment without interruptions, and the median follow-up was 32 weeks. In vivo dosimetry analysis revealed surface doses between 77% and 113% of the prescribed dose, with a mean of 92% of the prescribed radiation dose, and a standard deviation of 7% being delivered. Grade 2 dermatitis was found in 10 patients (53%), and Grade 3 dermatitis was found in one patient (5%). All cases of Grade 2 and 3 dermatitis were improved 4 weeks after PMRT. There were no cases of Grade 4 dermatitis and no chest wall recurrences during the treatment or follow-up period.Conclusions: The results confirmed the feasibility of using the 1-mm-thick daily bolus for PMRT, with appropriate dose buildup and acceptable skin toxicity without treatment interruptions.Trial registration: The University Hospital Medical Information Network Clinical Trials Registry, UMIN000035773. Registered 1 July 2019, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000040622
Mental Health of Preschool and Primary School Children: Dynamics and Improvement
Authors: Spichak Valentina , Sirotinkina Valentina , Sokolenova Irina , Akulinina Iuliia 
Published: December 2020

Abstract
Background: Improving the mental health of children is one of the main tasks for modern society. The aim of the work is to study the dynamics of mental health in preschool and primary school children under a psychological and pedagogical experiment. Methods: The study was conducted at 12 kindergartens (250 children) and 3 primary schools (200 children) in 2018 – 2019, in Moscow (Russian Federation). Children of each age group were divided into 2 groups according to the time spent on the Internet. The control group spent up to 15 minutes a day. The experimental group had an uncontrolled pastime. In total, there were 4 groups. The performance indicators (average score) and the dynamics of aggression were studied. The parents were provided with a survey. Children and parents had lectures with psychologists and teachers during the second academic year. The child aggression can be associated with an extra time spent on the Internet and the conniving attitude of parents. Results: The conducted research confirmed the importance of complex actions in reducing the aggressiveness and improving the mental health of children. The joint work of psychologists, parents and children themselves gave positive results. The control groups children significantly faster reduced aggressiveness by 1.4 - 1.6 times, on average, comparing to the experimental groups (1.2 times, p ≤ 0.05). The aggressiveness of children is associated with a lack of parents’ attention, that leads to uncontrolled surfing on the Internet and playing video games. Children from the experimental group demonstrated aggressive behavior 1.5 - 1.7 times more often than children from the control group (p ≤ 0.01). The survey of parents showed the same pattern. Thus, connivance of aggression and an aggressive reaction to communication with teachers were more significant (0.5 - 0.7 times, p ≤ 0.05) in the experimental group compared with the control. Conclusions: The improvement of the behavior of children was successful already after a 1 year of the experiment. The academic performance improved, while aggressiveness decreased in all groups.
Predictors of Adherence to Prescribed Exercise Programs for Older Adults With Medical or Surgical Indications for Exercise: a Systematic Review
Authors: Shaw Julia F , Pilon Sophie , Vierula Matthieu , McIsaac Daniel 
Published: December 2020

Abstract
BACKGROUND AND OBJECTIVES: Prescribed exercise to treat medical conditions and to prepare for surgery is a promising intervention to prevent adverse health outcomes for older adults; however, adherence to exercise programs may be low. Our objective was to identify and grade the quality of predictors of adherence to prescribed exercise in older adults. METHODS: Prospective experimental studies were identified using a peer-reviewed search strategy applied to MEDLINE, EMBASE, Cochrane and CINAHL from inception until October 6, 2020. Following independent and duplicate review of titles, abstracts and full texts, we included prospective studies with an average population age >65 years, where exercise was formally prescribed for a medical or surgical condition. We excluded studies where exercise was prescribed for a chronic musculoskeletal condition. Risk of bias was assessed using the Quality in Prognostic studies tool or Cochrane risk of bias tool, as appropriate. Predictors of adherence were identified, pooled, and graded for quality using an adaptation of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework for predictor studies.RESULTS: We included 19 observational studies and 4 randomized controlled trials (n=5785) Indications for exercise included cardiac (n=6), pulmonary rehabilitation (n=7), or other (n=10; surgical, medical, and neurologic). Of the 10 studies that reported adherence as the percent of prescribed sessions completed, average adherence was 80% (range 60%-98%; standard deviation (SD) 11%). Of the 10 studies that reported adherence as a categorical threshold demarking adherent vs not adherent, average adherence was 57.5% (range 21%-83%; SD 21%). Moderate-quality evidence suggested that positive predictors of adherence were self-efficacy and good self-rated mental health; negative predictors were depression (high quality) and distance from the exercise facility. Moderate-quality evidence suggested that comorbidity and age were not predictive of adherence.CONCLUSIONS: These findings can inform design of future exercise programs as well as identification of individuals who may require extra support to benefit from prescribed exercise.SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018108242
Urinary Sodium-To-Potassium Ratio Is A Dual Indicator Of Hypertension And Current Disease Activity In Patients With Rheumatoid Arthritis: A Cross-Sectional Study In The KURAMA Cohort Database
Authors: Minamino Hiroto , Katsushima Masao , Hashimoto Motomu , Fujita Yoshihito , Yoshida Tamami , Ikeda Kaori , Isomura Nozomi , Oguri Yasuo , Yamamoto Wataru , Watanabe Ryu , Murakami Kosaku , Murata Koichi , Nishitani Kohei , Tanaka Masao , Ito Hiromu , Ohmura Koichiro , Matsuda Shuichi , Inagaki Nobuya , Morinobu Akio 
Published: December 2020

Abstract
Background: Excessive salt intake is thought to exacerbate both development of hypertension and autoimmune diseases in animal models, but the clinical impact of excessive salt in rheumatoid arthritis (RA) patients is still unknown. We performed a cross-sectional study to clarify the associations between salt load index (urinary sodium-to-potassium ratio (Na/K ratio)), current disease activity and hypertension in an RA population.Methods: Three hundred thirty-six participants from our cohort database (KURAMA) were enrolled. We used the spot urine Na/K ratio as a simplified index of salt loading, and used the 28-Joint RA Disease Activity Score (DAS28-ESR) as an indicator of current RA disease activity. Using these indicators, we evaluated statistical associations between urinary Na/K ratio, DAS28-ESR and prevalence of hypertension.Results: Urinary Na/K ratio was positively associated with measured systolic and diastolic blood pressure and also with prevalence of hypertension even after covariate adjustment (OR 1.30, p < 0.001). In addition, increased urinary Na/K ratio was significantly and positively correlated with DAS28-ESR in multiple regression analysis (estimate 0.12, p < 0.001), as was also the case in gender-separated and prednisolone-separated sub-analyses.Conclusion: Urinary Na/K ratio was independently associated with current disease activity as well as with prevalence of hypertension in RA patients. Thus, dietary modifications such as salt restriction and potassium supplementation may well attenuate both disease activity and hypertension in RA patients.
Long-term Prognosis Analysis of PARACHUTE Device Implantation in Patients with Ischemic Heart Failure: A Single-Center Experience of Chinese patients
Authors: Li Jianghua , Liu Huadong , Liu Qiyun , Liu Cheng , Xiong Wei , Ma Wei , Zhang Baowei , Dong Shaohong , Li Tangzhiming 
Published: December 2020

Abstract
Background: Heart failure (HF) is one of the leading causes of mortality and morbidity. The PARACHUTE device is designed to partition for left ventricular (LV) apical aneurysm post extensive anterior myocardial infarction. However, the long-term prognosis of the PARACHUTE device post-implantation is unclear.Methods：From November 2015 to April 2017, six subjects with New York Heart Association Class II, III and IV ischemic HF, LV ejection fraction between 15% and 40%, and LV anterior apical aneurysm were enrolled in our center. The cumulative event rates for myocardial infarction, hospitalization, and mortality were documented respectively. Further assessment of LV ejection fraction, LV end-diastolic diameter, and estimated pulmonary artery pressure were determined by echocardiography core laboratory. For quantitative data comparison, paired t‑test was employed.Results: Device implantation was successful in all six enrolled subjects, and acute device association adverse events were not observed. At 4.6 ± 1.7 years follow-up, MACEs were found in 50% patients, and the survival rate was 86.7%. We found that the LV ejection fraction was significantly elevated after deployment (46.00 ± 6.00% vs. 35.83 ± 1.47%, P=0.009). Besides, the LVEDD elevated after MI (51.17 ± 3.71 vs. 62.83 ± 3.25, P<0.001) was revealed, but the device sustained preserved LVEDD after implantation.Conclusion: The PARACHUTE device is an alternative therapy for patients with severe LV maladaptive remodeling. The procedure of PARACHUTE implantation is safe and has a potential benefit in long-term mortality reduction. However, the device seems to increase the HF ratio.Clinical Trial Registration: NCT02240940, https://clinicaltrials.gov/ct2/ show/NCT02240940