bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute toxicity of Potentilla anserina L. extract in mice
Authors: Dram Dul , Zhao Cui-Zhu , Ma Qin-Ge , He Jun-Wei , Duo Jia-Jie , Dan Zhen , Wei Rong-Rui 
Published: May 2020

Abstract

Potentilla anserina L. is not only a medicinal plant, but also a traditional cuisine. Hence, an acute toxicity study was performed to confirm its safety profile. Forty Kunming mice were randomly divided into two groups: control group and P. anserina L. extract group. Using the maximum dosage method, the P. anserina L. extract group was given the maximum dose within 12 h, equivalent to 345.6 g/kg crude drug. The control group was given distilled water. After administration, toxicity symptoms of mice were observed, body weight and food intake were recorded. After 14 days, blood was collected to measure biochemical parameters, autopsy was carried out to observe the changes of organs, and the vital organs were separated, weighed, and preserved for histopathological examination. The results showed that P. anserina L. extract group had no toxic symptoms. The activity, weight, and diet of mice were normal, and no abnormality was found in organ index, renal function, liver function, anatomical observation, and histopathological examination. Therefore, the maximum oral dosage (345.6 g/kg) of P. anserina L. was good safety. This study indicated that P. anserina L. had a large safety range and the clinical application was safe.
HIV Tat Protein Selectively Impairs CB1Receptor-Mediated Presynaptic Inhibition at Excitatory But Not Inhibitory Synapses
Authors: Wu Mariah M. , Thayer Stanley A. 
Published: May 2020

AbstractDespite the success of antiretroviral therapy in suppressing viral load, nearly half of the 37 million people infected with HIV experience cognitive and motor impairments, collectively classified as HIV-associated neurocognitive disorders (HAND). In the CNS, HIV-infected microglia release neurotoxic agents that act indirectly to elicit excitotoxic synaptic injury. HIV trans-activator of transcription (Tat) protein is one such neurotoxin that is thought to play a major role in the neuropathogenesis of HAND. The endocannabinoid (eCB) system provides on-demand neuroprotection against excitotoxicity, and exogenous cannabinoids attenuate neurotoxicity in animal models of HAND. Whether this neuroprotective system is altered in the presence of HIV is unknown. Here, we examined the effects of Tat on the eCB system in rat primary hippocampal cultures. Using whole-cell patch-clamp electrophysiology, we measured changes in retrograde eCB signaling following exposure to Tat. Treatment with Tat significantly reduced the magnitude of depolarization-induced suppression of excitation (DSE) in a graded manner over the course of 48 h. Interestingly, Tat did not alter this form of short-term synaptic plasticity at inhibitory terminals. The Tat-induced decrease in eCB signaling resulted from impaired CB1receptor (CB1R)-mediated presynaptic inhibition of glutamate release. This novel loss-of-function was particularly dramatic for low-efficacy agonists such as the eCB 2-arachidonoylglycerol (2-AG) and Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive ingredient in marijuana. Our observation that HIV Tat decreases CB1R functionin vitrosuggests that eCB-mediated neuroprotection may be reducedin vivo; this effect of Tat may contribute to synaptodendritic injury in HAND.
Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice
Authors: Huda M Nazmul , VerHague Melissa , Albright Jody , Smallwood Tangi , Bell Timothy A , Que Excel , Miller Darla R , Roshanravan Baback , Allayee Hooman , Manuel de Villena Fernando Pardo , Bennett Brian J 
Published: May 2020

AbstractPlasma concentration of Cystatin C (CysC) level is a biomarker of glomerular filtration rate in the kidney. We use a Systems Genetics approach to investigate the genetic determinants of plasma CysC concentration. To do so we perform Quantitative Trait Loci (QTL) and expression QTL (eQTL) analysis of 120 Diversity Outbred (DO) female mice, 56 weeks of age. We performed network analysis of kidney gene expression to determine if the gene modules with common functions are associated with kidney biomarkers of chronic kidney diseases. Our data demonstrates that plasma concentrations and kidney mRNA levels of CysC are associated with genetic variation and are transcriptionally coregulated by immune genes. Specifically, Type-I interferon signaling genes are coexpressed with Cst3 mRNA levels and associated with CysC concentrations in plasma. Our findings demonstrate the complex control of CysC by genetic polymorphisms and inflammatory pathways.
The Sunset of Social Democracy in East-Central Europe: Case Study of Hungary
Authors: Gudžinskas Liutauras 
Published: May 2020

The article analyzes the reasons of the long-term decay of the Hungarian Socialist Party (MSZP) since 2010. The party ruled the country between 1994–1998 and 2002–2010 and was one of the strongest and most institutionalized political forces not only in Hungary but in the whole East-Central Europe. However, during the parliamentary elections in 2010, it suffered a crushing defeat by their main political opponents – “Fidesz,” led by V. Orbán. The organizational development of these two parties is compared. Collected evidence reveal the significance of centralized party rule and efforts to organize civil society in shaping the intra-competition of the main Hungarian political parties.
Synthesis, Characterization and In Silico Study of Fe(III) Complex with N'-(4-Chlorobenzoyl)-Isonicotino-Hydrazide as Anti Tuberculosis Candidate
Authors: Ruswanto Ruswanto , Setiawan Fajar , Rahayuningsih Nur , Mardianingrum Richa , Hidayati Nur Laili Dwi , Eryanti Elsi 
Published: May 2020

The synthesis of Fe(III) complexes with ligands N'-(4-Chlorobenzoyl)isonicotinohydrazide can be synthesized through mixing metal and ligand dissolved in ethanol by reflux at ± 75oC for 5 hours. The instruments for the characterization of the complex were used UV-Visible and Infrared Spectrophotometry. The aims of the study are: to determine the synthesis method, characterize of the complex, and to study the interaction of the complex with target receptors. The weight of the synthesized compound was obtained by 38.1 mg. The purity of the complex has been tested using the determination of melting point and got a melting point range was 196-198oC. The maximum wavelength of Fe(III)N'-(4-Chlorobenzoyl)isonicotinohydrazid) complex was 261.0 nm and provide absorption of Fe-O vibrations at wavenumbers 530.42 cm-1. The docking process was done using AutodockTools-1.5.6 software which shows that the Fe(III)N'-(4-Chlorobenzoyl) isonicotinohydrazide complex can interact with Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis and it has better interaction than isoniazid or N'-(4-Chlorobenzoyl)isonicotinohydrazide compound with the acquisition of free energy binding (ΔG) -9.80 kcal/mol and inhibition constant (Ki ) 0.06529 μM.
The comparison of revalcularization outcomes in acute coronary syndrom following primary coronary angioplasty
Authors: Abramova Olga V. , Saiganov Sergey A. 
Published: May 2020

Purpose. To compare clinical and morphofunctional outcomes of revascularization in patients after primary coronary angioplasty with different degree of coronary arteries damage and type of myocardial infarction.
Material and methods. The research involved 258 patients after myocardial infarction who underwent coronary balloon angioplasty with stenting infarct-related artery. By electrocardiographic and angiographic picture all patients were divided into 4 groups: Q-wave myocardial infarction and without Q-wave myocardial infarction with single-vessel and multivessel disease.
Results. The study found that the patients with non Q-wave myocardial infarction and single-vessel disease had no adverse clinical outcomes during a year. The wall motion index and the ejection fraction almost recovered completely (wall motion index varied from 1.18 0.02 to 1.05 0.02 and ejection fraction from 57.4 0.5% to 63.3 0.6%; р 0.001). All the patients with Q-wave myocardial infarction revealed similar clinical outcomes and morphofunctional characteristics. The group of patients with non Q-wave and multivessel disease had the highest rate of adverse clinical outcomes with progressing left-ventricular disfunction according to echocardiography (wall motion index varied from 1.15 0.01 to 1.19 0.04 and ejection fraction from 53.9 0.5% to 55.1 0.6%; р 0.001).
Conclusion. The degree of coronary arteries damage in the patients with Q myocardial infarction did not influence postinfarction remodeling and long-term cardiac outcomes. The patients with non-Q myocardial infarction and single-vessel disease had fewer signs of postinfarction remodeling and complications in postinfarction period. The worst prognosis was revealed by patients with similar forms of myocardial infarction and multivessel disease.
HUBUNGAN KEMAMPUAN METAKOGNISI SISWA DENGAN HASIL BELAJAR IPA MELALUI PENERAPAN MODEL PEMBELAJARAN BERBASIS MASALAH DI SMP NEGERI 2 KURIPAN
Authors: Anindya Ida Ayu Wiwin , Mahrus Mahrus , Hadiprayitno Gito 
Published: May 2020

Metakognisi merupakan suatu kemampuan seseorang mengenai pengetahuannya dan mengenali bagaimana proses berpikirnya sendiri. Penelitian tentang hubungan kemampuan metakognisi siswa dengan hasil belajar IPA telah dilakukan dengan tujuan untuk mengetahui hubungan kemampuan metakognisi siswa dengan hasil belajar IPA melalui penerapan model pembelajaran berbasis masalah di SMPN 2 Kuripan. Penelitian dilakukan pada bulan Juli sampai dengan Agustus 2016. Metode penelitian yang digunakan adalah deskriptif korelasional dengan pendekatan kuantitatif. Teknik pengambilan sampel menggunakan purposive, dan jumlah sampelnya sebanyak 41 siswa. Pengambilan data tentang kemampuan metakognisi siswa menggunakan Metacognitive Awareness Inventory (MAI) dan hasil belajar IPA menggunakan soal pilihan ganda. Pengambilan data dilakukan melalui pretest dan postest. Hasil penelitian menunjukkan bahwa terdapat peningkatan kemampuan metakognisi dengan rata-rata 0,11 untuk kelas VIII A dan 0,23 untuk kelas VIII E serta terdapat hubungan yang positif dan signifikan antara kemampuan metakognisi siswa dengan hasil belajar IPA. Pengaruh kemampuan metakognisi terhadap hasil belajar adalah 17%.
IMPLEMENTASI MODEL PEMBELAJARAN TAI TERHADAP ORAL ACTIVITIES DAN HASIL BELAJAR KOGNITIF C1-C4 MATERI EKSKRESI
Authors: Kusumasari Sri Eka , Saifuddin Much. Fuad 
Published: May 2020

Kegiatan pembelajaran IPA yang masih monoton membuat siswa kurang tertarik mengikuti kegiatan pembelajaran. Kurangnya aktivitas siswa dalam pembelajaran membuat nilai rata-rata ulangan harian di bawah KKM. Penelitian ini bertujuan untuk mengetahui implementasi model pembelajaran TAI terhadap oral activities dan hasil belajar kognitif C1-C4 pelajaran IPA siswa kelas VIII materi sistem ekskresi di SMP Muhammadiyah 9 Yogyakarta. Penelitian ini merupakan penelitian quasi eksperimen dengan desain penelitian posttest-only control design. Populasi dalam penelitian adalah siswa kelas VIII SMP Muhammadiyah 9 Yogyakarta T.A 2018/2019. Teknik pengumpulan data dengan cara observasi dan tes dengan instrumen penelitian lembar observasi dan soal tes. Data yang diperoleh dianalisis secara deskriptif kuantitatif. Hasil uji independent sample t-test oral activities menunjukkan signifikansi < nilai α yaitu 0,00 < 0,05. Hasil uji mann whitney hasil belajar C1-C4 menunjukkan Asymp.Sig. (2-tailed) < α yaitu 0,001 < 0,05. Sehingga dapat disimpulkan adanya pengaruh model TAI terhadap oral activities dan hasil belajar C1-C4.
PENGARUH MODEL PEMBELAJARAN BERBASIS MASALAH DENGAN METODE HYBRID LEARNING TERHADAP KETERAMPILAN KOMUNIKASI MAHASISWA PADA MATAKULIAH PENGEMBANGAN PROFESI GURU
Authors: Setiawan Deny , Irawati Mimien Henie , Indriwati Sri Endah , Sari Murni Sapta , Fachrunnisa Rifka , Mardiyanti Lely 
Published: May 2020

Keterampilan berkomunikasi yang efektif baik secara oral maupun tertulis merupakan salah satu kompetensi dalam menghadapi kehidupan di abad ke-21. Berdasarkan pengalaman membina matakuliah Pengembangan Profesi Guru, ditemukan mahasiswa kurang terampil dalam berkomunikasi, baik secara oral maupun tertulis. Pembelajaran berbasis berbasis masalah dengan metode Hybrid Learning dapat menjadi solusinya. Tujuan dari penelitian ini yaitu mengetahui pengaruh penerapan pembelajaran berbasis masalah dengan metode Hybrid Learning terhadap keterampilan komunikasi mahasiswa pada matakuliah Pengembangan Profesi Guru. Penelitian kuasi eksperimen ini dilakukan pada 2 kelas matakuliah Pengembangan Profesi Guru. Pengumpulan data keterampilan komunikasi dilakukan dengan rubrik observasi keterampilan komunikasi mahasiswa. Data dianalisis menggunakan statistika deskripstif dan independent t-test. Hasil penelitian memperlihatkan bahwa penerapan pembelajaran berbasis masalah dengan metode hybrid learning tidak menimbulkan perbedaan yang signifikan terhadap keterampilan komunikasi mahasiswa di kelompok kontrol dan kelompok eksperimen, khususnya di aspek konten serta tampilan dan informasi. keterampilan komunikasi, khususnya aspek orientasi dan sintaks, pada mahasiswa kelompok eksperimen lebih tinggi dari pada mahasiswa kelompok kontrol.
MARKA BAĞLILIĞI BELİRLEYİCİLERİNİN ETKİSİNİN KUŞAKLARARASI FARKLILIKLARININ ANALİZİ, APPLE&SAMSUNG ÜZERİNE BİR ARAŞTIRMA
Authors: ZENGİN Sevda 
Published: May 2020

Günümüzde artan rekabet koşullarından dolayı işletmelerin pazar konumunu koruması ve karlılığını sürdürebilmesi güçleşmektedir. Bundan dolayı da aynı pazara hitap eden işletmelerin rekabet etmek için kullandıkları araçların başında marka değeri boyutları gelmektedir. İşletmeler marka değeri boyutlarını kullanarak marka bağlılığı oluşturmak için; müşterinin markayı tanıması ve hatırlaması için bir marka farkındalığı yaratarak, güven duyabileceği bir marka imajı haline getirip, genel olarak ürün/hizmetin mükemmel seviyede olduğu algısını oluşturmaya çalışmaktadırlar.Buradan hareketle bu çalışmada, X, Y, Z kuşakları ile marka değeri boyutları arasındaki ilişkilerin incelenmesi amaçlanmıştır. Bu amaçla iki akıllı cihaz markası seçilmiş (Apple ve Samsung) ve veriler kolayda örnekleme yöntemi ile seçilen tüketicilerden yüz yüze anket yöntemi ile toplanmıştır. Araştırma sonuçlarına göre; her iki marka için üç kuşakta modelin anlamlı olduğu görülmektedir.
The Influence of Ottoman Empire on The Conservation of The Architectural Heritage in Jerusalem
Authors: Shehada Ziad M 
Published: May 2020

Abstract Jerusalem is one of the oldest cities in the world. It was built by the Canaanites in 3000 B.C., became the first Qiblaof Muslims and is the third holiest shrine after Mecca and Medina. It is believed to be the only sacred city in the world that is considered historically and spiritually significant to Muslims, Christians, and Jews alike. Since its establishment, the city had been subjected to a series of changes as the result of political, economic and social developments that affected the architectural formation through successive periods from the beginning leading up to the Ottoman Era, which then achieved relative stability. The research aims to examine and review the conservation mechanisms of the architectural buildings during the Ottomans rule in Jerusalem for more than 400 years, and how the Ottoman Sultans had contributed in revitalizing and protecting the city from loss and extinction. The researcher followed the historical interpretive method using descriptive analysis based on a literature review and preliminary study to determine Ottoman practices in conserving the historical and architectural heritage of Jerusalem. The research found that the Ottoman efforts towards conserving the architectural heritage in Jerusalem fell into four categories (Renovation, Restoration, Reconstruction and Rehabilitation). The Ottomans focused on the conservation of the existing buildings rather than new construction, because of their respect of local traditions and the holy places.
Examining Gender Representation in an Indonesian EFL Textbook
Authors: Agni Zango Anisa , Setyaningsih Endang , Sarosa Teguh 
Published: May 2020

Considering its influential role in students’ behavior and attitudes, a textbook has to reflect balanced images and information about males and females. It also has to support broad choices and many roles for both sexes to avoid unjust or bias gender issues. This study aimed at examining whether an EFL textbook published by the Indonesian government promotes gender equity by (1) mapping the proportion of textual and visual representation of males and females in the textbook; (2) describing how males and females are treated in the textbook. Through content analysis, the study revealed that the book is gender-biased as indicated from unbalanced (1) textual and visual representation (2) variety of activity, role, and occupation, (3) order of mention, and (4) adjectival portrayal. In all indicators, the female is underrepresented, hidden, and framed within traditional gender stereotyping. Reflecting on these findings, revision by the government and/ or careful treatment by teachers when using the book are ushered. Keywords: bias, content analysis, gender representation, gender stereotype, textbook.
ECONOMIC ANALYSIS OF DIFFERENT IRRIGATION DEPTHS IN FORAGE SORGHUM CROPS
Authors: RODRIGUES DE SOUSA PAULO GLEISSON , DE ARAÚJO VIANA THALES VINÍCIUS , DE CARVALHO CLAYTON MOURA , FIRMIANO DE SOUSA JOSÉ DE PAULA , CAMPOS KILMER COELHO , DE AZEVEDO BENITO MOREIRA 
Published: May 2020

The objective of this work was to evaluate the production costs and profitability indexes of sorghum crop for silage production under different irrigation depths. The work was conducted at the Federal Institute of Education, Science and Technology of Ceará (IFCE) – Umirim Campus, from September to December 2016. The treatments were arranged in 5 x 5 split plots with 5 replications. Irrigations were performed on a daily basis, and the applied depths were calculated based on crop evapotranspiration (ETc). The primary treatments were 50, 75, 100, 125 and 150% of ETc, associated with different levels of carnauba bagana mulch (0.00, 2.50, 3.75, 5.00, and 6.25 cm). Effective Operating Cost (EOC), Total Operating Cost (TOC), Gross Revenue (GR), Operating Profit (OP), Profitability Index (PI) and Break-Even Price (BEP) were estimated. According to the indicators analyzed, it was found that this is a promising crop within the different agricultural production schools, with favorable rates for the producer. The variety evaluated presents high resistance as to the water limitation factor, showing positive indicators such as break-even point below the average prices practiced in the region.
Cirugía ginecológica ambulatoria
Authors: Jiménez Becerra Alvaro , Marín Ardila Laureano 
Published: May 2020

1.Se hizo una evaluación, del servicio de Cirugía Ginecológica Ambulatoria de CAFAM, durante 3 años, desde su iniciación en marzo de 1980 a marzo de 1983.2.Se estudiaron 733 pacientes, a quienes se les practicaron 963 procedimientos quirúrgicos ginecológicos ambulatorios.3.Se informa de los análisis y evaluación de las pacientes, en sus aspectos médicos, socio-económicos, culturales y ambientales, que las hacen aptas para el programa de cirugía ambulatoria (8).4.Le corresponden a la cirugía ginecológica ambulatoria, 24.7% del total de cirugía realizada en el programa, lo que la ubica en el primer lugar.5.El 73% de las pacientes intervenidas están comprendidas entre los grupos socio-económicos A, B, C, que corresponde a la población con ingresos menores de $25.000.oo6.Se realizó, una amplia variedad de procedimientos ginecológicos, ocupando los primeros lugares el:—Raspado uterino—Ligadura de trompas—Colpoperincorrafia ant-posterior—Laparoscopia diagnósticaMerece especial mención, el haber practicado 123 Colporrafias antero- posteriores y además, operaciones de Manchester, Miomectomíasy extirpaciones de quistes de ovarios sin apoyo hospitalario.7.Todos los procedimientos fueron realizados con anestesia general, a excepción de uno con anestesia peridural y uno con anestesia local.8.El tiempo quirúrgico, osciló entre 15 y 90 minutos.9. La mortalidad fue nula y la morbilidad, alcanzó el 0.95%, la hospitalización post-quirúrgica fue del 0.1%.10.El tiempo de internación quirúrgica osciló entre 2 y 10 horas.11.Con este trabajo, se demuestra la bondad de los programas de cirugía ambulatoria ginecológica en CAFAM.
Estudio ecográfico en obstetricia y ginecología en 1982
Authors: Ulloa Sánchez Jorge 
Published: May 2020

En la Fundación Clínica David Restrepo los primeros pasos en ECOGRAFIA los dimos a partir de marzo de 1982, durante los últimos diez meses de ese año realizamos un total de novecientos cuarenta y cinco (945) estudios a pacientes de la Clínica y de otras Instituciones; el 84.22% correspondió a casos Obstétricos, el 13,87% a casos Ginecológicos y el 1.91% a casos Gineco-obstétricos.En los casos ginecológicos encontramos treinta y seis (36) Miomatosis uterinas, once (11) Quistes de ovario, diez y siete (17) Poliquistosis ováricas y seis (6) Abscesos tubáricos.Dentro de los casos gineco-obstétricos hallamos doce (12) Miomas y Embarazo, uno (1) Quíste de ovario y Embarazo, dos (2) Tumores de ovario y Embarazo, dos (2) Dispositivos ¡ntra-uterinos (Y) y embarazo y uno (1) caso de Quiste de ovario derecho y Embarazo ectópico izquierdo.Los estudios obstétricos correspondieron a treinta y cinco (35) de Patología ovular junto con tres (3) Embarazos molares, ocho (8) Ectópicos, cuarenta y ocho (48) casos de "Aborto" en sus distintos "estadios", veinte (20) Embarazos gemelares, sesenta y cinco (65) casos de Patología de localización placentaria, trece (13) casos de Patología placentaria en pacientes con algún grado de diabetes, siete (7) en pacientes con incompatibilidad Rh, diez y seis (16) en pacientes con algún grado de hipertensión, Pre-eclampsia y/o añosidad, diez y siete (17) muertes fetales ¡n-útero, cuatro (4) malformaciones congénitas y quinientos cincuenta y nueve (559) casos informados como embarazos normales.
Monitoría fetal anteparto en relación con la morbi-mortalidad fetal en el Hospital de San José de Bogotá
Authors: Afanador Rojas Jaime , Montoya Sánchez Germán , Correa Uribe Alfonso 
Published: May 2020

Se hace una revisión de las monitorías fetales ante-parto, pruebas de NST durante un período de un año; tomando los parámetros de interpretación de las pruebas de NST en el Hospital de San José de Bogotá y comparándolo con los postulados enunciados por Evertson y Schifrin. Se correlacionaron las pruebas NST según la interpretación que se les dió en el Hospital de San José y según la nueva interpretación siguiendo los parámetros de Evertson y Schifrin con el estado del niño al nacer, valorado según el Apgar, la presencia o no de meconio y el estado del peso del recién nacido. Se pudo concluír, que siguiendo parámetros de interpretación adecuados la prueba de NST es un método muy acertado para valorar el estado perinatal, ya que hubo una correlación directa de la prueba, siendo ésta reactiva o no reactiva con el Apgar, con la presencia o no de meconio y el estado del peso del niño al nacer. La mortalidad perinatal que se encontró para las pruebas reactivas fue de un 0% y para las no reactivas de un 11%.