bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reaction of Amines with NO at room temperature and atmospheric pressure: is nitroxyl a reaction intermediate?
Authors: Hamer Mariana , Suarez Sebastián A. , Muñoz Martina , Álvarez Lucía , Marti Marcelo , Doctorovich Fabio 
Published: August 2020

Abstract
The novelty of this work lies in the experimental confirmation that alkylamines react with Nitric oxide (NO) in aqueous solution at room temperature and atmospheric pressure conditions releasing HNO. We combined spectroscopic, electrochemical, and kinetic techniques to describe the reactions intermediates and characterized end products determined by UV–vis, NMR, and GC-MS. Nitrosamine and propene were detected for the reactions of diethylamine and isopropylamine, showing differential mechanisms between primary and secondary alkylamines. Finally, mechanistic analysis using ab-initio methods was performed and compared with the molecular mechanism proposed for the decomposition of NONOates. The results are discussed in the context of the growing interest in the NO/HNO interconversion reactions, required to understand their overlapping and different reactivity.
On the discovery of new elements (IUPAC/IUPAP Report)
Authors: Hofmann Sigurd , Dmitriev Sergey N. , Fahlander Claes , Gates Jacklyn M. , Roberto James B. , Sakai Hideyuki 
Published: August 2020

AbstractAlmost thirty years ago the criteria that are currently used to verify claims for the discovery of a new element were set down by the comprehensive work of a Transfermium Working Group, TWG, jointly established by IUPAC and IUPAP. The recent completion of the naming of the 118 elements in the first seven periods of the Periodic Table of the Elements was considered as an opportunity for a review of these criteria in the light of the experimental and theoretical advances in the field. In late 2016 the Unions decided to establish a new Joint Working Group, JWG, consisting of six members determined by the Unions. A first meeting of the JWG was in May 2017. One year later this report was finished. In a first part the works and conclusions of the TWG and the Joint Working Parties, JWP, deciding on the discovery of the now named elements are summarized. Possible experimental developments for production and identification of new elements beyond the presently known ones are estimated. Criteria and guidelines for establishing priority of discovery of these potential new elements are presented. Special emphasis is given to a description for the application of the criteria and the limits for their applicability.
Study of prognostic and diagnostic significance of P53 and PTEN mutation in proliferative lesions of endometrium.
Authors: Ray Dr. Suchandra , Jha Dr. Ashish , Afreen Islam Dr. Ayesha , Sengupta Dr. Moumita 
Published: August 2020

Background: Endometrial hyperplasia essentially implies an overgrowth of the endometrium. Complex hyperplasia associated with cellular atypia, seems to be the most important predictor of malignant potential. Endometrioid Endometrial Carcinomas account for three-fourths of Endometrial Carcinomas and are thought to develop following a continuum of premalignant lesions ranging from endometrial hyperplasia without atypia, to hyperplasia with atypia, and finally to well-differentiated carcinoma. Currently the most frequently observed gene mutation in endometrioid carcinoma is located on chromosome 10 and is related with the PTEN gene (phoshatase and tensin homolog). PTEN inactivation is found to correlate with clonal growth pattern detected in endometrial hyperplasia and carcinoma. The p53 tumor suppressor gene locates to chromosome 17p13. The abnormal p53 expression has been found in 11% of grade 1 endometrioid endometrial carcinoma, while p53 mutations occur in 90%
of non-endometrioid endometrial carcinoma.
Aims and objectives: In this study we aim to evaluate the immuno histochemical expression of P53 and PTEN genes in endometrial hyperplasia and endometrial carcinoma and correlate their expression with prognostic outcomes like grade and stage, in cases of endometrial carcinoma.
Material and methods: A prospective study of 60 patients with abnormal uterine bleed in the peri and post menopausal age was conducted, for a period of three years. Histological specimens were studied for HPE and IHC for the markers PTEN and P53.
Results: The mean age for hyperplastic and carcinomatous lesions was 44.9 years and 53.2 years respectively. 35% (21 cases) were endometrial hyperplasia and 65% (39 cases) of cases were endometrial carcinoma. Among endometrial carcinoma 87% are of endometrioid type and 13% are of other types, which include serous, clear and malignant mixed Mullerian type of carcinoma. IHC study showed that PTEN expression is higher in endometrial hyperplasia than endometrial carcinoma cases. Elevated P53 expression correlated with poor differentiation of endometrial cancer. P53 was found to be more in cases with FIGO staging III &IV compared to stage I & II (100% vs 18.1% p value= 0.0016) and grade 3 compared to grade 1&2 (50% vs 0 p value= 0.0116).
Conclusion: Immuno histochemical biomarkers like PTEN and P53 may contribute to better tumor characterization and thus more precisely determine its clinical behavior.
Key words: endometrial hyperplasia, endometrial carcinoma, PTEN, P53.
Perfil dos usuários de benzodiazepínicos que frequentam uma drogaria da região Noroeste do Rio Grande do Sul
Authors: Kowalski Layza , Schneider Marília Salet , Alves Izabel Almeida 
Published: August 2020

Objetivo: Traçar o perfil dos usuários de benzodiazepínicos, por meio da coleta de dados em forma de entrevista guiada por questionário nos meses de agosto a outubro do ano de 2017 no município de Cerro Largo. Metodologia: Trata-se de um estudo transversal, observacional, descritivo e prospectivo que envolveu usuários de benzodiazepínicos de ambos os sexos e idades. Resultados: A maioria dos entrevistados (68%) pertencia ao sexo feminino, com idade média dos pacientes do sexo feminino foi de 59,7 ± 17,0 anos. Já a idade média dos pacientes do sexo masculino foi de 61,7 ± 12,4. O tempo médio de uso foi de 1 a 3 anos e o medicamento mais utilizado foi o clonazepam 2,5 mg/ml. Entre os pacientes entrevistados, 52% receberam prescrição de um médico clínico geral. Conclusão: O estudo sugere a ocorrência de uso indevido desta classe de medicamentos por períodos longos. Salienta-se que a dispensação farmacêutica deve assumir papel complementar ao serviço médico para maior resolutividade do tratamento farmacológico independente da faixa etária do usuário, com orientações quanto ao uso, risco de dependência e efeitos adversos, além de auxiliar no cuidado do paciente através pela relação paciente e prescritor.
Efeito da atividade física sobre densidade mineral óssea de mulheres pós menopausa
Authors: Porto Elias Ferreira , Kümpel Claudia , Batista Ilzane Da Silva Souza , Filoni Eduardo , De Castro Antônio Adolfo Mattos , Souza Jonatas Da Silva , Ferracioli Ana Maria Jora 
Published: August 2020

Introdução: A osteoporose vem sendo um grande problema de saúde pública, tem se tornado uma das principais doenças incapacitantes principalmente de mulheres, por apresentar um menor pico de massa óssea e também pelas consequências provenientes da menopausa. Um importante exame deve ser feito a densitometria óssea, sendo um meio não invasivo para a avaliação de pacientes com osteoporose, possibilitando a realização de seu diagnóstico e seguimento. Objetivo: avaliar se a atividade física regular e no estilo de vida podem influenciar na densidade mineral óssea de mulheres maiores de 40 anos. Método: Estudo transversal com abordagem quantitativa, composto por dois grupos, o Grupo I formado por mulheres fisicamente ativas (25), e o Grupo II foi formado por mulheres sedentárias (25). Todos responderam aos seguintes questionários: Questionário internacional de atividade física versão curta (IPAQ), Escala Perfil de Estilo de Vida Individual (NAHAS), e um questionário elaborado pelos avaliadores com o objetivo de obter informações mais especificas dos avaliados. Foram incluídas mulheres maiores de 40 anos, que realizaram o exame de densitometria óssea, que fazia ou não atividade física. Resultados: Foram avaliadas 50 mulheres sendo que 25 eram ativas fisicamente e 25 sedentárias, a idade média foi de 60,6±9,7 anos, com IMC de 26,5±6,1kg/m2. 8% da amostra eram tabagistas 8% consumiam bebidas alcoólicas regularmente 33% eram diabéticas, 30% era dislipidêmico e 63% eram hipertensas. A proporção de indivíduos sedentários que dissera que sua saúde era pior em relação a pessoas de sua mesma idade foi significantemente maior do que para o grupo de mulheres ativa fisicamente, isto também foi visto quando perguntado se a sua saúde tinha piorado em relação há um ano anterior (p=0,003) e (p=0,003) respectivamente. O estilo de vida não foi diferente significantemente entre os grupos; porem a densidade mineral óssea da colona lombar foi significante maior para o grupo dos indivíduos fisicamente ativos. O T-score e o Z-score foram significantemente mais negativos no seguimento do fêmur total para o grupo sedentário do que no grupo dos ativos fisicamente. Conclusão: Diante dos resultados obtidos evidencia-se que o estilo de vida e a atividade estão diretamente relacionados com a densidade mineral óssea de mulheres pós-menopausa.
"I mellemtiden har jeg lært alle den sociologiske forståelses sygdomme at kende."
Authors: Krais Beate , Bourdieu Pierre 
Published: August 2020

Abstract
In 1968 École des Hautes Études en Sciences Sociales and Mouton Éditeurs published the book Le métier de sociologue. Préalables épistemologiques by Pierre Bourdieu, Jean-Claude Chamboredon og Jean-Claude Passeron. In 1991, 23 years later Walter de Gruyter published, at the same time, a German and an slightly edited English version of the second edition of the French original. Especially the number of illustrative texts was reduced.
Connected to the publishing Pierre Bourdieu was interviewed by Beate Krais from "Max-Planck-Institut für Bildungsforschung". She asked Bourdieu to explain the genesis of Le métier de sociologue, the positions within the sociological research milieu the book is related to, and what happened since then. In the interview especially two of Bourdieu's demands for sociology to be a science are in focus, the construction of the scientific object and the double break.
Caracterización de las bibliotecas universitarias en la ciudad de Medellín, Colombia
Authors: Restrepo-Betancurt Luis Fernando 
Published: August 2020

Objetivo: evaluar los servicios que prestan las bibliotecas universitarias en la ciudad de Medellín, contrastándolos por sexo y tipo de universidad. Método: se utilizó un estudio descriptivo, comparativo, exploratorio de tipo multidimensional, con preguntas de tipo cerrado, en escala dicótoma (de acuerdo, en desacuerdo) y multimodal (bueno, regular y malo). Se empleó análisis multivariado de varianza (MANOVA) con contraste canónico de tipo ortogonal, análisis factorial y análisis descriptivo exploratorio de tipo unidimensional. Resultados: las bibliotecas universitarias privadas cuentan con mayor tecnología en equipos computacionales y en servicios de conexión a internet, mientras las estatales poseen mejor material bibliográfico y atención al usuario, lo que permite un mejor desarrollo investigativo por parte de los estudiantes. En general, la percepción de los sexos es muy similar en lo referente al servicio que presta la biblioteca; la mayor diferencia se detectó en lo relacionado al aspecto ambiental, donde el sexo femenino tiene mejor concepto. Discusión y Conclusiones: en general, el concepto de los estudiantes con respecto a las bibliotecas universitarias, fue bueno, donde al 78% de ellos señaló que les gusta visitar la biblioteca.
Um estudo bibliométrico sobre a pesquisa operacional aplicada à sustentabilidade ## A bibliometric study on operational research applied to sustainability
Authors: De Abreu Victor Hugo Souza , Baltar Marina Leite de Barros , Santos Andrea Souza 
Published: August 2020

ResumoA sustentabilidade está sendo cada vez mais vista como uma possível solução para os problemas decorrentes, principalmente, da ação humana no meio ambiente. Entretanto, para que seus efeitos sejam observados à longo prazo faz-se necessário que sejam utilizadas abordagens como a Pesquisa Operacional (PO) que busca solucionar, ou pelo menos minimizar, problemas reais e complexos, fornecendo apoio aos tomadores de decisão. Nesse sentido, este estudo busca realizar uma revisão da literatura com abordagem bibliométrica que tem como objetivo identificar estudos que utilizam a PO aplicada à sustentabilidade. Para obter e compilar as informações, foram utilizados os bancos de dados do Web of Science™, que apresenta alcance e cobertura satisfatórios. Os resultados mostram, por exemplo, que o assunto, embora antigo, continua em expansão, sendo publicados estudos em periódicos com elevada relevância científica. Além disso, nota-se que a utilização da PO é uma importante estratégia de suporte aos tomadores de decisão brasileiros de diversas áreas do conhecimento tais como saúde pública, gerenciamento urbano e rural e engenharia para promoção da sustentabilidade. AbstractSustainability is increasingly being seen as a possible solution to problems arising mainly from human action on the environment. However, for its long-term effects to be observed, it is necessary to use approaches such as Operational Research (OR) which seeks to solve, or at least minimize, real and complex problems, providing support to decision makers. Thus, this study conducts a literature review with a bibliometric approach that aims to identify studies that use the OR applied to sustainability. To obtain and compile the data, we used Web of Science ™ databases, which have satisfactory range and coverage. The results show, for example, that the despite being an old subject, it is still expanding, with studies published in journals with high scientific relevance. In addition, it is noted that the use of OR is an important strategy to support Brazilian decision makers from various areas of knowledge such as public health, urban and rural management, and engineering to promote sustainability.
Análise da disposição de consumo por orgânicos em uma indústria de cereais ## Analysis of consumption disposal by organic in a cereal industry
Authors: Hsu Pang Lien , Dietrichkeit Emerson , Barboza José Vinícius Santos , Johann Jerry Adriani , Bertolini Geysler Rogis Flor 
Published: August 2020

ResumoO artigo apresentado tem por objetivo analisar se os consumidores estão dispostos e até quanto pagariam para adquirir produtos orgânicos em relação aos produtos tradicionais de uma indústria de cereais do interior do Paraná, sendo escolhidos para o trabalho, os três mais vendidos pela organização: Milho para pipoca, Amendoim e Canjiquinha. O estudo em questão foi aplicado a 221 consumidores em dois supermercados localizados em Cascavel – PR e os resultados foram analisados pelo modelo Bertolini (2009) adaptado. O estudo demonstrou que há consumidores dispostos a pagarem um valor adicional por produtos orgânicos, como também gerou um estudo preliminar em relação aos custos e retornos que a empresa pode sofrer com a oferta dos produtos orgânicos, demonstrando que podem comercializar esses produtos no mercado a um custo unitário superior ao tradicional, além de que foi possível identificar que os consumidores que não pagariam a mais pelo produto orgânico continuariam a consumir o produto tradicional. AbstractThe presented article aims to examine whether consumers are willing to pay and how much they are willing to expend for organic products over traditional products of a cereal industry of Paraná state, for this case the three most sold produtcs by the organization was chosen: Maize popcorn, Peanuts and ground corn grits. The study in question was administered to 221 consumers in two supermarkets located in Cascavel - PR and the results were analyzed by adapted Bertolini model (2009). The study showed that there are consumers willing to pay an additional amount for organic products, but also generated a preliminary study on the costs and returns that the company may suffer by offering these organic products, demonstrating that they can offer these products to the market with a higher unit cost than the traditional, and also it was possible to identify that consumers who would not pay more for organic products continue to consume traditional product.
Assessment of drug utilization pattern in patients undergoing chemotherapy for various types of metastatic cancers in a tertiary care government hospital
Authors: Vijayalakshmi D. , Bendi Srinivas Rao , Usharani Motakatla , Swarna Latha K. 
Published: August 2020

Background: Cancer is one among main causes of morbidity and mortality in developing and developed countries. The World Cancer Report 2014 of World Health Organization’s (WHO’s) International Agency for Research on Cancer (IARC), states that in 2012 the global incidence of cancer increased to a 14 million new cases, the figure expected to rise to an annual 19.3 million by 2025. The prescription pattern of anticancer drugs has evolved considerably in recent years because of better understanding of underlying pathophysiology of carcinomas as well as introduction of newer drugs. Methods: It was a hospital-based prospective, cross-sectional study conducted in Department of Oncology, GGH, Kakinada for a period of twelve months from February 2017 to January 2018. A total of 100 patients were enrolled using convenience sampling technique. Patient demographics like age, gender, educational level, employment status, marital status, smoking category, alcohol consumption, stage of cancer was collected. Drug utilization pattern was obtained from inpatient case reports, prescriptions and medication charts used during a chemotherapy cycle.Results: Among all anticancer drugs, cisplatin and 5-flurouracil were most commonly prescribed followed by Adriamycin. The most commonly used adjuvant drugs were B-complex, diclofenac, granisetron, ranitidine, dexamethasone. Antibiotic use was found to be very limited.Conclusions: Various anticancer drug prescription patterns are being used for treatment of patient with metastatic cancers. In this study, cisplatin and 5-flurouracil were commonly used. Injudicious antibiotic prescribing was not observed.
Data-based decision-making practices in secondary schools of North Gondar, Ethiopia
Authors: Fitsumbirhan Gebremedhin , Asrat Aster , Kelkay Asrat Dagnew 
Published: August 2020

The main purpose of this study was to examine data-based decision-making practices in secondary schools of North Gondar. Descriptive design was employed in the study. Data were collected from 14 principals, 28 vice principals and 78 department heads through a questionnaire which contained closed and open-ended items and from document analysis. Regarding the sampling of participants, systematic sampling was used for selecting the sample districts; principals and vice principals were selected using comprehensive sampling and purposive sampling were used to select the department heads. The result of the analysis shows that the secondary schools under study had varieties of decision areas and data available for their decisions but they did not use such data available properly to address the decision areas specified. From this, it was possible to conclude that the data-based decision-making in secondary schools was not practiced as expected and it was highly affected by a host of factors like poor scientific methods of data collection, lack of data analysis practices using different techniques and poor data storage and retrieval systems in secondary schools. It is, therefore, recommended that training in skill and awareness development on data-based decision-making should be provided to school teachers in the area.

Keywords: Data-based, decision-making, practice and secondary school.
Explicating Practice Norms and Tensions Between Values in Resident Training in Family Medicine
Authors: Achkar Morhaf Al 
Published: August 2020

Abstract
Background. Residency programs have the intricate and complex role of training health care providers. But little is known about what residents and attendings consider norms of practice or the tensions among different values residents are expected to uphold. Thus, dialogical and reflective frameworks are being explored for resident learning.Methods. This study examined the use of facilitated conversations with groups of residents and attending physicians while reviewing video-recorded resident–patient interactions. The conversations were recorded, transcribed, and qualitatively analyzed.Results. A total of 24 residents and 10 attendings participated in conversations while separately and in parallel groups reviewing 15 resident sessions. Residents explicated the norms of practice and evaluated their performance, which often agreed with those of attending physicians in calling out important learning opportunities. When disagreement occurred, residents’ explications of their reasoning were often relevant and, via reflection and dialogue, helped clarify intentions that were not apparent in the videos. Residents and attendings often judged actions on more than one domain of value. For instance, if a resident addressed problems, built relationships in a timely manner, and acted autonomously without jeopardizing the quality of care, she satisfactorily performed her duty.Conclusions. Practice norms and value struggles were addressed by participants during reviews, which provided a promising framework for learning and assessment. Also, the non-hierarchical structure opened space to acknowledge a diversity of positions and for tensions among values to be explicated.
Prophylactic antibiotic treatment with TMP-SMX decreased the incidence of interstitial pneumonia in patients with B-cell lymphoma on chemotherapy
Authors: Li Cong , Lu Fangxiao , Tao Lei , Yu Haifeng , Chen Xi , Peng Shuailing , Han Shuiyun , Yang Haiyan 
Published: August 2020

Abstract
Background Several studies have reported the incidence of interstitial pneumonia (IP) among patients with non-Hodgkin lymphoma (NHL) that are undergoing combination chemotherapy plus rituximab; however, the effective prophylactic treatment for IP remains unclear. This study aims to explore the prophylactic effect of trimethoprim-sulfamethoxazole (TMP-SMX) on IP and identify IP-associated risk factors in NHL patients.Methods Between March 2013 and April 2018, 498 patients (264 males, 53%) with B-cell NHL undergoing first-line RCHOP-like chemotherapy treatment with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone were enrolled in this study.Results These patients had a median age of 56 years, and 311 of the 498 patients (62.4%) were administered once daily with the prophylactic treatment of TMP-SMX. IP occurred in 65 patients (13.1%), indicating a significant reduction in the IP incidence rate (21.4% vs. 8.0%; p<0.001). Among patients treated with TMP-SMX, 2 (1.2%) exhibited rashes, 38 (12.2%) suffered from nausea and vomiting, 52 (16.7%) showed signs of neutropenia, and 18 (5.8%) suffered from kidney dysfunction. Both univariate and multivariate analysis showed that gender (male), history of diabetes, and absence of prophylactic TMP-SMX treatment were significant risk factors associated with IP. Disease progression was observed in 55/311 (17.7%) patients that underwent prophylactic TMP-SMX treatment and in 63/187 (33.7%) patients that did not (p<0.001).Conclusions This study revealed that the occurrence of IP was common in B-cell NHL patients undergoing combined chemotherapy plus rituximab treatment. IP could be reduced with prophylactic treatment of once-daily oral TMP-SMX.