bluuebunny/crossref_metadata_2025_split huggingface dataset:
Odor Sensitivity Versus Odor Identification in Older US Adults: Associations With Cognition, Age, Gender, and Race
Authors: Xu Lucy , Liu Jia , Wroblewski Kristen E , McClintock Martha K , Pinto Jayant M 
Published: May 2020

Abstract
The ability to identify odors predicts morbidity, mortality, and quality of life. It varies by age, gender, and race and is used in the vast majority of survey and clinical literature. However, odor identification relies heavily on cognition. Other facets of olfaction, such as odor sensitivity, have a smaller cognitive component. Whether odor sensitivity also varies by these factors has not been definitively answered. We analyzed data from the National Social Life, Health, and Aging Project, a nationally representative study of older US adults (n = 2081). Odor identification was measured using 5 validated odors presented with Sniffin’ Stick pens as was odor sensitivity in a 6-dilution n-butanol constant stimuli detection test. Multivariate ordinal logistic regression modeled relationships between olfaction and age, gender, race, cognition, education, socioeconomic status, social network characteristics, and physical and mental health. Odor sensitivity was worse in older adults (P &lt; 0.01), without gender (P = 0.56) or race (P = 0.79) differences. Odor identification was also worse in older adults, particularly men (both P ≤ 0.01), without differences by race. Decreased cognitive function was associated with worse odor identification (P ≤ 0.01) but this relationship was weaker for odor sensitivity (P = 0.02) in analyses that adjusted for other covariates. Odor sensitivity was less strongly correlated with cognitive ability than odor identification, confirming that it may be a more specific measure of peripheral olfactory processing. Investigators interested in associations between olfaction and health should consider both odor sensitivity and identification when attempting to understand underlying neurosensory mechanisms.
COVID-19 Pandemic: Time to Revive the Cyclophilin Inhibitor Alisporivir
Authors: Pawlotsky Jean-Michel 
Published: May 2020

Abstract
December 2019 saw the emergence of a new epidemic of pneumonia of varying severity, called coronavirus disease 2019 (COVID-19), caused by a newly identified coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV-2). No therapeutic option is available to treat this infection that has already killed &gt; 310 000 people worldwide. This Viewpoint summarizes the strong scientific arguments supporting the use of alisporivir, a nonimmunosuppressive analogue of cyclosporine A with potent cyclophilin inhibition properties that has reached phase 3 clinical development, for the treatment of COVID-19. They include the strong cyclophilin dependency of the life cycle of many coronaviruses, including severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, and preclinical data showing strong antiviral and cytoprotective properties of alisporivir in various models of coronavirus infection, including SARS-CoV-2. Alisporivir should be tested without delay on both virological and clinical endpoints in patients with or at risk of severe forms of SARS-CoV-2 infection.
Multiomics-based characterization of specialized metabolites biosynthesis in Cornus Officinalis
Authors: Rai Amit , Rai Megha , Kamochi Hidetaka , Mori Tetsuya , Nakabayashi Ryo , Nakamura Michimi , Suzuki Hideyuki , Saito Kazuki , Yamazaki Mami 
Published: May 2020

Abstract
Cornus officinalis, an important traditional medicinal plant, is used as major constituents of tonics, analgesics, and diuretics. While several studies have focused on its characteristic bioactive compounds, little is known on their biosynthesis. In this study, we performed LC-QTOF-MS-based metabolome and RNA-seq-based transcriptome profiling for seven tissues of C. officinalis. Untargeted metabolome analysis assigned chemical identities to 1,215 metabolites and showed tissue-specific accumulation for specialized metabolites with medicinal properties. De novo transcriptome assembly established for C. officinalis showed 96% of transcriptome completeness. Co-expression analysis identified candidate genes involved in the biosynthesis of iridoids, triterpenoids, and gallotannins, the major group of bioactive metabolites identified in C. officinalis. Integrative omics analysis identified 45 cytochrome P450s genes correlated with iridoids accumulation in C. officinalis. Network-based integration of genes assigned to iridoids biosynthesis pathways with these candidate CYPs further identified seven promising CYPs associated with iridoids’ metabolism. This study provides a valuable resource for further investigation of specialized metabolites’ biosynthesis in C. officinalis.
Micromagnetic simulations of first-order reversal curve (FORC) diagrams of framboidal greigite
Authors: Valdez-Grijalva Miguel A , Nagy Lesleis , Muxworthy Adrian R , Williams Wyn , Roberts Andrew P , Heslop David 
Published: May 2020

SUMMARY
Greigite is a sensitive environmental indicator and occurs commonly in nature as magnetostatically interacting framboids. Until now only the magnetic response of isolated non-interacting greigite particles have been modelled micromagnetically. We present here hysteresis and first-order reversal curve (FORC) simulations for framboidal greigite (Fe3S4), and compare results to those for isolated particles of a similar size. We demonstrate that these magnetostatic interactions alter significantly the framboid FORC response compared to isolated particles, which makes the magnetic response similar to that of much larger (multidomain) grains. We also demonstrate that framboidal signals plot in different regions of a FORC diagram, which facilitates differentiation between framboidal and isolated grain signals. Given that large greigite crystals are rarely observed in microscopy studies of natural samples, we suggest that identification of multidomain-like FORC signals in samples known to contain abundant greigite could be interpreted as evidence for framboidal greigite.
Time–frequency windowing in multiparameter elastic FWI of shallow seismic wavefield
Authors: Athanasopoulos Nikolaos , Manukyan Edgar , Bohlen Thomas , Maurer Hansruedi 
Published: May 2020

SUMMARYFull-waveform inversion of shallow seismic wavefields is a promising method to infer multiparameter models of elastic material properties (S-wave velocity, P-wave velocity and mass density) of the shallow subsurface with high resolution. Previous studies used either the refracted Pwaves to reconstructed models of P-wave velocity or the high-amplitude Rayleigh waves to infer the S-wave velocity structure. In this work, we propose a combination of both wavefields using continuous time–frequency windowing. We start with the contribution of refracted P waves and gradually increase the time window to account for scattered body waves, higher mode Rayleigh waves and finally the fundamental Rayleigh wave mode. The opening of the time window is combined with opening the frequency bandwidth of input signals to avoid cycle skipping. Synthetic reconstruction tests revealed that the reconstruction of P-wave velocity model and mass density can be improved. The S-wave velocity reconstruction is still accurate and robust and is slightly benefitted by time–frequency windowing. In a field data application, we observed that time–frequency windowing improves the consistency of multiparameter models. The inferred models are in good agreement with independent geophysical information obtained from ground-penetrating radar and full-waveform inversion of SH waves.
Devolution of competition policy under the Scotland Act 2016 after Brexit: straining at the edges of the current settlement?
Authors: Andreangeli Arianna 
Published: May 2020

ABSTRACT
The purpose of this article is to examine the challenges that Brexit brings for the devolution of certain aspects of competition policy to Scotland. According to section 63 of the Scotland Act 2016, Scottish Ministers can ask the Competition and Markets Authority (CMA) to carry out a phase 2 market investigation after having sought the agreement of their Westminster counterparts. This article will explore the consequences of Brexit for competition policy in the UK by placing the discussion against the broader background of the relationship existing between the central and devolved governments in the UK, with a particular emphasis on Scotland. After discussing, the nature and scope of the powers that have been devolved to the Scottish Government the article will examine the impact of Brexit on competition policy both in general and for these devolved aspects. It will be argued that the current system for the management of the inter-governmental relations between Westminster and Edinburgh may not be able to withstand the challenges brought by Brexit and affecting the role of the CMA and of the UK Government, respectively, in the fields of antitrust, state aid, and merger control.
The article will conclude that Brexit has exposed how the current framework for intergovernmental relations may not be suitable to the demands of new forms of devolution that are not predicated upon the distinction between reserved and devolved matters, but depend on the joint decision-making between the UK and the Scottish governments. Thus, unless section 63 of the Scotland Act 2016 is to remain ineffective, it may become necessary to rethink the current ways in which Scottish and UK minister interact in areas where devolution means co-decision as opposed to one government ‘giving way’ to the other.
Upscaling Pest Management From Parks to Countries: A New Zealand Case Study
Authors: Chand Ravneel R , Cridge Belinda J 
Published: May 2020

AbstractWorldwide, introduced pest species create significant challenges to native biodiversity and individual health. New Zealand has an extensive history of attempting to protect biodiversity from introduced pests such as the Brushtail possum (Trichosurus vulpecula [Diprotodontia: Phalangeridae]). Success has been achieved on a small scale, but the transition to the whole country management poses new issues. Therefore, this review uses the framework of ‘Predator Free 2050’ to summarize current practices and scrutinize new technologies. Importantly, we include a toxicology focus to the discussion, providing detail on the mechanism(s) of action that inform decisions regarding the pros and cons for the use of various chemical agents. Currently, the New Zealand government supports the use of sodium fluoroacetate (1080) for predator control on a mass scale, but this comes with a social opposition that is not always reflective of the underlying science. Understanding this controversy is vital if new strategies are to be deployed to achieve large-scale pest management. We use New Zealand as a case study in this area because its unique and isolated ecosystem provides a global opportunity for understanding new technologies and best practice.
Pull-through resection without free-flap reconstruction for lateral wall oropharyngeal cancer
Authors: Matsumoto Fumihiko , Kobayashi Kenya , Omura Go , Matsumura Satoko , Matsumoto Yoshifumi , Fukasawa Masahiko , Yoshimoto Seiichi 
Published: May 2020

Abstract

Background
While transoral robotic surgery (TORS) is widely used for the management of lateral wall oropharyngeal carcinomas (OPC), open surgical techniques are still used in some cases. A pull-through method for open surgical resections of OPC has recently been introduced. We improved on this method by eliminating the need for subsequent free-flap reconstruction.

Methods
16 patients with lateral wall OPC underwent pull-through resections. After resection, we used the digastric muscle, stylohyoid muscles, submandibular gland and the surrounding tissues to block the neck and oral cavity and to avoid reconstruction.

Results
This novel technique was performed without major complications or morbidities. The average post-operative hospital stay was 14.6 ± 6.1 days, and the average duration until initiation of oral intake post-operation was 6.5 ± 2.9 days. Oncological outcomes, post-operative course and function were acceptable.

Conclusions
Our novel method provides an efficient and less invasive surgical technique than conventional open approaches.
Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location
Authors: Labadie Julia D , Harrison Tabitha A , Banbury Barbara , Amtay Efrat L , Bernd Sonja , Brenner Hermann , Buchanan Daniel D , Campbell Peter T , Cao Yin , Chan Andrew T , Chang-Claude Jenny , English Dallas , Figueiredo Jane C , Gallinger Steven J , Giles Graham G , Gunter Marc J , Hoffmeister Michael , Hsu Li , Jenkins Mark A , Lin Yi , Milne Roger L , Moreno Victor , Murphy Neil , Ogino Shuji , Phipps Amanda I , Sakoda Lori C , Slattery Martha L , Southey Melissa C , Sun Wei , Thibodeau Stephen N , Van Guelpen Bethany , Zaidi Syed H , Peters Ulrike , Newcomb Polly A 
Published: May 2020

AbstractBackgroundPostmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogeneous disease, we evaluated whether the association of HT and CRC differs across etiologically relevant, molecularly defined tumor subtypes and tumor location.MethodsWe pooled data on tumor subtypes (microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, pathway: adenoma-carcinoma, alternate, serrated), tumor location (proximal colon, distal colon, rectum), and HT use among 8220 postmenopausal women (3898 CRC cases and 4322 controls) from 8 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CIs) for the association of ever vs never HT use with each tumor subtype compared with controls. Models were adjusted for study, age, body mass index, smoking status, and CRC family history. All statistical tests were 2-sided.ResultsAmong postmenopausal women, ever HT use was associated with a 38% reduction in overall CRC risk (OR =0.62, 95% CI = 0.56 to 0.69). This association was similar according to microsatellite instability, CpG island methylator phenotype and BRAF or KRAS status. However, the association was attenuated for tumors arising through the serrated pathway (OR = 0.81, 95% CI = 0.66 to 1.01) compared with the adenoma-carcinoma pathway (OR = 0.63, 95% CI = 0.55 to 0.73; Phet =.04) and alternate pathway (OR = 0.61, 95% CI = 0.51 to 0.72). Additionally, proximal colon tumors had a weaker association (OR = 0.71, 95% CI = 0.62 to 0.80) compared with rectal (OR = 0.54, 95% CI = 0.46 to 0.63) and distal colon (OR = 0.57, 95% CI = 0.49 to 0.66; Phet =.01) tumors.ConclusionsWe observed a strong inverse association between HT use and overall CRC risk, which may predominantly reflect a benefit of HT use for tumors arising through the adenoma-carcinoma and alternate pathways as well as distal colon and rectal tumors.
Impact of a Best Practice Advisory for Pediatric Patients With Staphylococcus aureus Bacteremia
Authors: Lloyd Elizabeth C , Martin Emily T , Dillman Nicholas , Nagel Jerod , Chang Robert , Gandhi Tejal N , Tribble Alison C 
Published: May 2020

Abstract

Background
Infectious diseases (ID) consultation and optimal antibiotic therapy improve outcomes in Staphylococcus aureus bacteremia (SAB). Data on strategies to improve adherence to these practices in children are limited.

Methods
This was a quasi-experimental study evaluating the impact of an electronic medical record (EMR)–based best practice advisory (BPA) for SAB, recommending ID consult and optimal antibiotic therapy based on rapid mecA gene detection. Inpatients &lt; 21 years old with SAB before (January 2015–July 2017) and after (August 2017–December 2018) BPA implementation were included. Primary outcome was receipt of ID consult. Secondary outcomes included receipt of optimal therapy, time to ID consult and optimal therapy, recurrent SAB, and 30-day all-cause mortality. ID consultation rates pre- and postimplementation were compared using interrupted time series (ITS) analysis. Hazard ratios (HRs) and 95% confidence intervals (CIs) for time to optimal therapy were calculated using Cox regression.

Results
We included 99 SAB episodes (70 preintervention, 29 postintervention). Preintervention, 48 (68.6%) patients received an ID consult compared to 27 (93.1%) postintervention, but this was not statistically significant on ITS analysis due to a preexisting trend of increasing consultation. Median hours to optimal therapy decreased from 26.1 to 5.5 (P = .03), most notably in patients with methicillin-sensitive S. aureus (MSSA) (42.2 to 10.8; P &lt; .01). On Cox regression, BPA implementation was associated with faster time to optimal therapy (HR, 3.22 [95% CI, 1.04–10.01]).

Conclusions
Implementation of an EMR-based BPA for SAB resulted in faster time to optimal antibiotic therapy, particularly for patients with MSSA. ID consultation increased throughout the study period and was not significantly impacted by the BPA.
Sleeve gastrectomy without bougie is safe and effective operation: case report
Authors: Shekh Zkria Atia , Roqaia Abdulkafi Hasan 
Published: May 2020

Abstract
Sleeve gastrectomy (SG) is an effective method for weight loss; it is done by laparoscopy or open approach; it is a restrictive procedure and involves removing part of the stomach by cutting over bougie, which ensures that stenosis doesn’t occur. Bougie may cause esophageal perforation. There are studies that show the size of bougie used and weight loss are related. We show a case of open SG without using bougie at all. It is an effective and safe method and results in ~30% of weight loss 3 months after the operation without complications; thus, we conclude that SG can be done without bougie.
A case-series of bloodstream infections caused by theMeyerozyma guilliermondiispecies complex at a reference center of oncology in Brazil
Authors: Chaves Alessandra Leal Silva , Trilles Luciana , Alves Gabriela Machado , Figueiredo-Carvalho Maria Helena Galdino , Brito-Santos Fábio , Coelho Rowena Alves , Martins Ianick S , Almeida-Paes Rodrigo 
Published: May 2020

AbstractBloodstream infections (BSI) caused by Candida species are the fourth cause of healthcare associated infections worldwide. Non-albicans Candida species emerged in the last decades as agents of serious diseases. In this study, clinical and microbiological aspects of six patients with BSI due to the Meyerozyma (Candida) guilliermondii species complex from an oncology reference center in Brazil, were evaluated. To describe demographic and clinical characteristics, medical records of the patients were reviewed. Molecular identification of the isolates was performed by ITS1-5.8S-ITS2 region sequencing. Antifungal susceptibility was evaluated by the EUCAST method and the minimal inhibitory concentrations (MIC) assessed according to the epidemiological cutoff values. Virulence associated phenotypes of the isolates were also studied. Ten isolates from the six patients were evaluated. Five of them were identified as Meyerozyma guilliermondii and the others as Meyerozyma caribbica. One patient was infected with two M. caribbica isolates with different genetic backgrounds. High MICs were observed for fluconazole and echinocandins. Non-wild type isolates to voriconazole appeared in one patient previously treated with this azole. Additionally, two patients survived, despite infected with non-wild type strains for fluconazole and treated with this drug. All isolates produced hemolysin, which was not associated with a poor prognosis, and none produced phospholipases. Aspartic proteases, phytase, and esterase were detected in a few isolates. This study shows the reduced antifungal susceptibility and a variable production of virulence-related enzymes by Meyerozyma spp. In addition, it highlights the poor prognosis of neutropenic patients with BSI caused by this emerging species complex.Lay AbstractOur manuscript describes demographic, clinical and microbiological characteristics of patients with bloodstream infection by the Meyerozyma guilliermondii species complex at a reference center in oncology in Brazil.
ExoMol line lists – XXXVIII. High-temperature molecular line list of silicon dioxide (SiO2)
Authors: Owens A , Conway E K , Tennyson J , Yurchenko S N 
Published: May 2020

ABSTRACT
Silicon dioxide (SiO2) is expected to occur in the atmospheres of hot rocky super-Earth exoplanets but a lack of spectroscopic data is hampering its possible detection. Here, we present the first, comprehensive molecular line list for SiO2. The line list, named OYT3, covers the wavenumber range 0 – 6000 cm−1 (wavelengths λ &gt; 1.67 μm) and is suitable for temperatures up to T = 3000 K. Almost 33 billion transitions involving 5.69 million rotation–vibration states with rotational excitation up to J = 255 have been computed using robust first-principles methodologies. The OYT3 line list is available from the ExoMol data base at www.exomol.com.
SDSS-IV MaNGA: The kinematic-morphology of galaxies on the mass versus star-formation relation in different environments
Authors: Wang Bitao , Cappellari Michele , Peng Yingjie , Graham Mark 
Published: May 2020

ABSTRACT
We study the link between the kinematic-morphology of galaxies, as inferred from integral-field stellar kinematics, and their relation between mass and star formation rate. Our sample consists of ∼3200 galaxies with integral-field spectroscopic data from the MaNGA survey (Mapping Nearby Galaxies at Apache Point Observatory) with available determinations of their effective stellar angular momentum within the half-light radius $\lambda _{R_e}$. We find that for star-forming galaxies, namely along the star formation main sequence (SFMS), the $\lambda _{R_e}$ values remain large and almost unchanged over about two orders of magnitude in stellar mass, with the exception of the lowest masses $\mathcal {M}_{\star }\lesssim 2\times 10^{9} \, \mathcal {M}_{\odot }$, where $\lambda _{R_e}$ slightly decreases. The SFMS is dominated by spiral galaxies with small bulges. Below the SFMS, but above the characteristic stellar mass $\mathcal {M}_{\rm crit}\approx 2\times 10^{11} \, \mathcal {M}_{\odot }$, there is a sharp decrease in $\lambda _{R_e}$ with decreasing star formation rate (SFR): massive galaxies well below the SFMS are mainly slow-rotator early-type galaxies, namely genuinely spheroidal galaxies without discs. Below the SFMS and below $\mathcal {M}_{\rm crit}$ the decrease of $\lambda _{R_e}$ with decreasing SFR becomes modest or nearly absent: low-mass galaxies well below the SFMS, are fast-rotator early-type galaxies, and contain fast-rotating stellar discs like their star-forming counterparts. We also find a small but clear environmental dependence for the massive galaxies: in the mass range $10^{10.9}\!-\!10^{11.5} \, \mathcal {M}_{\odot }$, galaxies in rich groups or denser regions or classified as central galaxies have lower values of $\lambda _{R_e}$. While no environmental dependence is found for galaxies of lower mass. We discuss how the above results can be understood as due to the different star formation and mass assembly histories of galaxies with varying mass.