bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extended Platelet‐Rich Fibrin as a Membrane for Lateral Window Sinus Lifts: A Case Series
Authors: Estrin Nathan E. , Basma Hussein , Espinoza Alan Rene , Pinto Marco Antonio Castro , Pikos Michael A. , Miron Richard J. 
Published: December 2024

ABSTRACTIntroductionPlatelet‐rich fibrin (PRF) is being increasingly utilized in surgical procedures due to various improvements in clinical outcomes. More recently, a heating process to denature albumin in the platelet poor plasma (PPP) layer has been shown to extend the resorption time of PRF from a typical 2‐week period to 4–6 months. Because of its > 4 month resorption properties, extended PRF (e‐PRF) membranes have been used in dentistry as an alternative to collagen membranes in alveolar ridge preservations, ridge augmentations, soft tissue grafting, and as a barrier membrane in lateral sinus grafting procedures.Materials and MethodsA total of 22 patients from 3 different clinical facilities participated in this multicenter case series study. All clinicians completed a standard lateral window sinus technique with sticky bone utilizing allograft, xenograft, or autologous dentin with an e‐PRF membrane utilized for sole coverage of the lateral window. The survival rate at second stage implant surgery (~6 months) and radiographic analysis determined on consecutive radiographs: (1) the mean residual bone height (RBH) under the maxillary sinus at implant placement and (2) the change in endosinus bone level, were calculated to assess the endosinus bone changes at 6 months.ResultsBetween June 2022 and December 2023, 22 patients were included in this study. Patients included 12 women and 10 men with a mean age of 58.8 years, ranging from 32 to 78 years. In 22 lateral window sinuses completed, a total of 31 implants were placed. All patients healed uneventfully without any post‐operative complications. Post‐op CBCTs were taken at 6 months to demonstrate successful sinus floor augmentation and to calculate endosinus gain. No soft tissue invagination was encountered in any of the study participants nor displacement of the graft material into the buccal mucosa. In one case highlighted in this study, the e‐PRF membrane was utilized to repair a sinus perforation. The average 6‐month post‐operative sinus height was 12.3 mm with a mean change in endosinus bone gain of 8.0 mm.ConclusionUtilizing extended‐PRF membranes in place of collagen membranes for coverage of the lateral window during sinus floor elevation was shown to be a successful treatment modality in this case series. These findings provide new opportunities utilizing denatured albumin membranes in implant dentistry and paves the way for additional applications. The material is 100% autologous, low cost. This is the first case series study highlighting its novel use for coverage of the lateral window during sinus grafting. Larger longitudinal studies are now needed with comparison to standard resorbable membranes as well as long‐term follow‐up of implants placed into sites grafted with e‐PRF membranes.
Caffeine's Neuroprotective Effect on Memory Impairment: Suppression of Adenosine A2A Receptor and Enhancement of Tyrosine Hydroxylase in Dopaminergic Neurons Under Hypobaric Hypoxia Conditions
Authors: Zhong Zhifeng , Dong Huaping , Zhou Simin , Lin Chaoqun , Huang Pei , Li Xiaoxu , Zhang Jijian , Xie Jiaxin , Wu Yu , Li Peng 
Published: December 2024

ABSTRACTAimsChronic hypobaric hypoxia frequently results in memory deficits, with severe cases showing marked alterations in dopamine levels and its metabolites. This research explores caffeine's modulation of the adenosine A2A receptor (A2AR) and its regulatory effects on tyrosine hydroxylase (TH), aiming to restore dopamine homeostasis and mitigate memory impairments associated with hypoxia. The goal is to identify novel preventive strategies against cognitive decline induced by hypoxia.MethodsNetwork pharmacological analysis was employed to predict the interactions between caffeine, cognitive function, and hypobaric hypoxia‐related disorders. The novel object recognition and Y‐maze tests were utilized to assess caffeine's impact on memory deficits under hypobaric hypoxia conditions in male mice. LC–MS/MS analysis was subsequently conducted to examine the variations in dopamine and its metabolites within the midbrain. Molecular docking further confirmed the binding affinities between A2AR and caffeine, as well as TH and caffeine. Additionally, immunofluorescence and protein‐protein docking were employed to elucidate the interaction between A2AR and TH.ResultsThe findings highlight the pivotal role of adenosine receptors and dopamine‐related pathways in the interplay between caffeine, cognition, and hypobaric hypoxia‐related disorders. Behavioral tests demonstrated that caffeine effectively alleviated memory impairments caused by chronic hypobaric hypoxia. LC–MS/MS results revealed significant differences in dopamine, metanephrine, and 3‐hydroxyanthranilic acid levels following caffeine treatment for hypoxia‐induced cognitive deficits. Molecular docking confirmed the high affinity between A2AR and caffeine, as well as TH and caffeine, while immunofluorescence and protein–protein docking provided insights into the A2AR‐TH interaction and its modulation during hypobaric hypoxia.ConclusionsCaffeine exhibits potent neuroprotective effects against chronic high‐altitude‐induced cognitive impairments, potentially through its action on A2AR, leading to enhanced TH expression and subsequent release of dopamine and its related neurotransmitters.
Real‐world evidence in the cloud: Tutorial on developing an end‐to‐end data and analytics pipeline using Amazon Web Services resources
Authors: Anderson Wes , Bhatnagar Roopal , Scollick Keith , Schito Marco , Walls Ramona , Podichetty Jagdeep T. 
Published: December 2024

AbstractIn the rapidly evolving landscape of healthcare and drug development, the ability to efficiently collect, process, and analyze large volumes of real‐world data (RWD) is critical for advancing drug development. This article provides a blueprint for establishing an end‐to‐end data and analytics pipeline in a cloud‐based environment. The pipeline presented here includes four major components, including data ingestion, transformation, visualization, and analytics, each supported by a suite of Amazon Web Services (AWS) tools. The pipeline is exemplified through the CURE ID platform, a collaborative tool designed to capture and analyze real‐world, off‐label treatment administrations. By using services such as AWS Lambda, Amazon Relational Database Service (RDS), Amazon QuickSight, and Amazon SageMaker, the pipeline facilitates the ingestion of diverse data sources, the transformation of raw data into structured formats, the creation of interactive dashboards for data visualization, and the application of advanced machine learning models for data analytics. The described architecture not only supports the needs of the CURE ID platform, but also offers a scalable and adaptable framework that can be applied across various domains to enhance data‐driven decision making beyond drug repurposing.
Unveiling Diagnostic Clues of NTRK‐Rearranged Spindle Cell Neoplasms in Fine‐Needle Aspiration Specimens
Authors: Xie Yilin , Zhou Diwei , Peng Li , Chang Xiaona , Zhong Jingmin 
Published: December 2024

ABSTRACTNTRK (neurotropic tropomyosin receptor kinase)‐rearranged spindle cell tumours represent a rare group of molecularly defined soft tissue neoplasms. These tumours, excluding infantile fibrosarcomas, are characterised by NTRK gene rearrangements and exhibit a range of histomorphologies, including spindle, epithelioid or rhabdoid cells with invasive growth. Their prognosis correlates with histological grade, and surgical resection is the primary treatment. The abnormally expressed oncogenic receptor tyrosine kinases TRK‐A, TRK‐B and TRK‐C in this tumour have been shown to be therapeutical targetable, which may improve patient prognosis. We report a 17‐year‐old male patient presenting with a left axillary mass. Both fine‐needle aspiration cytology (FNAC) and surgical resection specimens were submitted for examination. Comprehensive analysis of cytomorphology, immunohistochemical staining results and next‐generation sequencing (NGS) data led to a final diagnosis of NTRK‐rearranged spindle cell tumour. By comparing cytological and histological morphologies, we identified diagnostic clues in cytological specimens. NTRK‐rearranged spindle cell tumours' definitive diagnosis enables targeted therapy. Fine‐needle aspiration cytology, being minimally invasive, offers the potential for earlier and more definitive diagnoses, thereby improving patient treatment options.
Home‐based detoxification for individuals with alcohol or drug dependence: A systematic review of the recent literature
Authors: Rens Eva , Ceelen Anna , Martens Nicolaas , Van Camp Lynn , Destoop Marianne 
Published: December 2024

AbstractIssueThere is growing awareness of the benefits of treating patients in their own home, yet home‐based detoxification of individuals with substance use disorder has received limited attention. While home‐based alcohol detoxification seems to be safe and effective for patients without severe withdrawal, little is known about detoxification for illicit or polysubstance dependence. This review synthesises recent findings on home‐based detoxification for alcohol and other substances.ApproachA systematic search of published and unpublished studies from 2010 onwards was conducted. Studies describing home detoxification interventions and programs, along with qualitative, quantitative and mixed‐methods research, were included. Study quality was assessed using the Mixed Methods Appraisal Tool. Findings were narratively synthesised.Key FindingsEleven publications were included. Many studies are descriptive, explorative or use a small sample, but four studies are of high quality. Five publications focused exclusively on alcohol detoxification. The outcomes in reducing or abstaining from substance use seem acceptable, except for opioids. Patients and families reported high satisfaction, viewing it as less stressful than inpatient care. However, no conclusions can be drawn regarding the effectiveness compared to other detoxification settings.ImplicationsThe limited evidence base illustrates a great need for further investigation and controlled trials of home‐based detoxification and comparison between detoxification settings. Investigating the broader applicability across substances is crucial.ConclusionHome‐based detoxification shows potential as a safe and patient‐preferred intervention, though more research is required to assess its broader effectiveness and feasibility across various substances. It could play a valuable role within established care models.
Changes in socio‐economic inequality in alcohol‐attributable mortality in periods of increasing and decreasing alcohol affordability
Authors: Mäkelä Pia , Lindell Elsi 
Published: December 2024

AbstractIntroductionReducing alcohol affordability reduces alcohol‐related harm but its impact on socio‐economic inequalities requires further study. We examine changes in alcohol‐attributable mortality inequalities in Finland during periods of sharply rising (2000–2007) and falling (2008–2017) alcohol affordability.MethodsLinking individual‐level register data on causes of death and socio‐demographics for the Finnish population aged ≥25 in 2000–2017 (68 million person‐years), we analysed age‐standardised monthly alcohol‐attributable mortality rates by sex and income quintile (n = 32,699 alcohol‐attributable deaths). Regression models were used to analyse mortality trends in the two periods, contrasting high‐ and low‐income groups.ResultsInequalities in alcohol‐attributable mortality between low‐ and high‐income groups were large throughout the study period. During the period of rising alcohol affordability, mortality increased among high‐income men with an average monthly increase of 0.17% (p = 0.046). This rate was even higher among low‐income men, increasing by 0.55% per month, that is, +0.38 percentage points more than the rate for high‐income men (p = 0.002). Among women, mortality increased at similar rates in both income groups. During the period of falling alcohol affordability, mortality decreased among high‐income men with an average monthly decrease of −0.21% (p < 0.001), and it decreased even more among low‐income men (−0.40%, i.e., −0.19 percentage points more, p = 0.030). Among women, the decreases were not statistically significant.Discussion and ConclusionsThe results indicate that increased alcohol affordability was associated with widening socio‐economic inequalities while reduced affordability was linked with narrowing inequalities among men. Reducing alcohol affordability is thus a recommendable policy for reducing socio‐economic inequality in alcohol‐related harm.
Laser and light‐based treatments for port‐wine birthmarks – a systematic review and network meta‐analysis
Authors: Nguyen Lynhda , Sorbe Christina , Schoen Gerhard , Schneider Stefan W. , Herberger Katharina 
Published: December 2024

SummaryPort‐wine birthmarks (PWB) are common vascular malformations in infants. Despite various laser and light‐based treatments, comparative data on their effectiveness is limited. This study compares different treatments for PWB using a systematic review and network meta‐analysis (NMA). We searched for randomized controlled trials (RCTs) and ongoing studies up to November 2023: Primary outcomes were patient satisfaction, investigator‐assessed reduction in redness, and long‐term adverse events (AEs). Risk of bias was assessed using the Cochrane Risk of Bias 2 Tool.We identified 27 RCTs for qualitative analysis and twelve RCTs for the NMA, covering 1033 observations, 19 treatments, and three sub‐networks. Seven studies reported on patient satisfaction. Hemoporfin‐mediated photodynamic therapy was more effective in lesion clearance than PDL but had the highest risk of AEs. The 755 nm alexandrite laser and the combination of 595 nm PDL + 1064 nm Nd:YAG also showed high AE risks. Treatment discontinuation rates due to AEs did not significantly differ. Most studies had unclear bias risks, mostly owing to insufficient reporting.This study is the first NMA comparing laser‐ and light‐based therapies for PWB. Further well‐designed studies are warranted to determine optimal methods and patient‐influencing factors for individualized treatments.
The Effectiveness of the Flipped Learning Model in Improving Second/Foreign Language Metacognitive Listening Awareness and Strategy Use
Authors: Azarniyoosh Samaneh , Roohani Ali 
Published: December 2024

ABSTRACTThis study investigated the effectiveness of the flipped learning model, compared with the nonflipped learning model, in improving second/foreign language metacognitive listening awareness and perceived strategy use. For this purpose, 40 young adult learners studying English as a foreign language in two intact classes were selected. They were assigned into flipped and nonflipped groups, which received flipped and nonflipped instruction, respectively. A mixed‐methods embedded design was adopted. Data were gathered by employing the Metacognitive Awareness Listening Questionnaire and diaries. Analysis of covariance and thematic analysis revealed that the flipped model significantly fostered the learners' metacognitive awareness and strategy use in listening. Although the strategies related to planning and evaluation, person knowledge, directed attention, mental translation and problem solving were used in both groups, the flipped group demonstrated a greater tendency to use the metacognitive strategies requiring high‐order processes. Flipped learning can drive L2 students to become metacognitively strategic listeners.
Compared Influence of a Lubricant on Mode I and Mode II Fatigue Crack Growth Kinetics in a Gear Steel
Authors: Doquet Véronique , Zaid Maël , Bonnand Vincent , Pacou Didier , Chiaruttini Vincent , Depouhon Pierre 
Published: December 2024

ABSTRACTThe influence of a helicopter gearbox lubricant on Mode I or Mode II fatigue crack growth in 16NCD13 steel was characterized through tests performed on single‐edge notched tensile samples loaded in tension–compression and on cruciform samples submitted to reversed shear plus static biaxial compression, respectively. In Mode I, the lubricant reduced the growth rate at low ΔKI and increased the threshold
, while in Mode II, it accelerated crack growth at low ΔKIIeffective, which was not only due to a reduction in crack face friction. The upward convective flow of lubricant carrying debris exuding from the crack, a modification in oil aspect and properties, and chemical analyses near the crack front suggest that a temperature‐induced degradation of the lubricant leads to a corrosive attack of the metal, which accelerates crack growth. A tribologically transformed structure is observed along the lips of cracks grown in Mode II with normal compression in oil.
DIE ‘GOTTESRECHTE DES MENSCHEN’: HUMAN RIGHTS AS SECULARISED RIGHTS IN HEINRICH HEINE'S ESSAYS
Authors: Cha Kyung‐Ho 
Published: December 2024

ABSTRACTHeinrich Heine shows in his essays on France and Germany that human rights have a religious prehistory. For him, ‘Menschheitsrechte’ are not merely secular rights but secularised rights. The human rights proclaimed in the American and French Revolutions are the secularised historical form in which the fundamental ‘Urrechte der Menschheit’ manifest themselves. This article takes as its starting point the observation that, for Heine, religions have a political dimension and political movements a religious dimension. His history of primal rights or human rights begins with Judaism and Christianity and leads via the philosophy of the Enlightenment and the revolutions of the eighteenth century to Saint‐Simonism and pantheism. The article focuses on Heine's texts of the 1830s, when he envisages Saint‐Simonism and pantheism as the new religions of his time that bring about the emancipation of the spirit and the body, whose rights had been neglected until then.
Improving grinding efficiency and performance of new impeller type ball mill using discrete element method simulations and Taguchi method
Authors: Li Daiwei , Zeng Dan , Liu Zhiwen , Zhang Mingjun , Li Fazhi 
Published: December 2024

AbstractIn this paper, a new grinding method utilizing impeller‐driven particle motions was proposed. A discrete element kinetic model for simulating the grinding process of SiO2 material was established. Through the quantitative analysis of energy conversion during grinding, the kinetic energy of particles, the kinetic energy of materials, and the energy consumed by materials were identified as three indicators for evaluating the grinding efficiency and performance of the ball mill. The optimal impeller structural parameters for improving the energy conversion efficiency of the ball mill were determined using the Taguchi method. The grinding efficiency and microstructure performance of the impeller type and traditional ball mills were compared. The results show that the energy loss between the materials and impeller accounted for the most significant proportion, about 30.4% of the total conversion energy. Based on the signal‐to‐noise ratio analysis, the optimum structural parameters of the impeller were obtained as follows: the height–diameter ratio of 1/2, blade thickness of 3 mm, inclination angle of 80°, and blade number of 5. Compared with planetary and horizontal ball mills, the average particle size of powders ground with the impeller‐type ball mill improved by 8.16% and 11.38%, respectively, and the particle uniformity increased by 1.22% and 26.5%.
Developing and Validating an Academic Vocabulary List in Chinese
Authors: Jia Xiaogang , Wei Yaoyu , Liu Kanglong , Lei Lei 
Published: December 2024

AbstractThe research on academic vocabulary lists has been a topic of interest for decades, as a good command of academic words may in part define a learner's academic performance. With China's increasing international impact over the past decades, more learners have chosen to learn Chinese as their foreign language. In response, a few word lists of general Chinese have been developed, while no vocabulary list of academic Chinese is available. In this study, we developed the Academic Vocabulary List in Chinese (AVLC) based on our home‐made large‐scale dataset of academic Chinese. The words to be included in our list were carefully selected with strict criteria regarding frequency, range, dispersion, and discipline measures. Our AVLC list contains 594 words, which explain 12.28% of the corpus data. In addition, their coverage in academic texts is much higher than that in non‐academic texts, such as news and literary works, which shows that the AVLC includes words that are particularly used in academic texts. The AVLC is, to our knowledge, the first vocabulary list of academic Chinese. Pedagogical implications and directions for future research are also discussed in the study.
The Role of Wnt5a in Inflammatory Diseases
Authors: Yu Xin‐hua , Guo Xin‐ning , Li Kui , Li Jia‐wei , Wang Kaijin , Wang Dan , Liu Bi‐cui 
Published: December 2024

ABSTRACTWnt5a plays an important role in cell development and maturation and is closely associated with various diseases, such as malignant tumours, metabolic disorders, fibrosis, growth and development. Recent studies have shown that Wnt5a expression and signal transduction are strongly involved in the inflammatory response. This study comprehensively reviewed the latest research progress on the association between Wnt5a and several inflammatory diseases, such as sepsis, asthma, chronic obstructive pulmonary disease, tuberculosis, rheumatoid arthritis, atherosclerosis and psoriasis vulgare. We elucidated the mechanism by which the Wnt5a protein is involved in the pathogenesis of these diseases, providing a basis for the prevention and treatment of inflammatory diseases.
Tailoring dielectric properties of flexible ceramic sheets through graphene doping in the diatomite matrix
Authors: Chiberio Paulo H. , Alves Hugo P. A. , Neto João M. Dantas , Carvalho Bruno R. , Silva Elialdo C. , Acchar Wilson , Vaz Filipe , Lopes C. , Ferreira Armando , Correa Marcio A. 
Published: December 2024

AbstractThis work presents a novel tape‐casting method for producing flexible, graphene‐enhanced diatomite ceramic sheets. These sheets target dielectric substrates for applications in the critical yet under‐explored, high‐frequency range. Structural and morphological analyses confirmed the incorporation of graphene nanoplatelets into the ceramics matrix, validating the efficiency of the tape‐casting process. The results show the crucial role of the composite's crystalline structure in its dielectric response, where oxygenated functional groups within the graphene nanoplatelets act as intrinsic barriers to restrict leakage current, resulting in low dielectric loss. Doping of flexible ceramic plates with graphene nanoplatelets led to significant dielectric variations of approximately 100% over a wide frequency range. The capacitance increased by 215.35 with the addition of 10 wt. graphene compared to pure diatomite. Our results demonstrate the ability to adapt the framework's structural, morphological, and dielectric properties through doping with graphene in diatomite, offering promising prospects for applying flexible ceramic sheets at high frequency.