bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minocycline prevents and repairs the skin disorder associated with afatinib, one of the epidermal growth factor receptor-tyrosine kinase inhibitors for non-small cell lung cancer
Authors: Sano Kazumi , Nakadate Kazuhiko , Hanada Kazuhiko 
Published: April 2020

Abstract
Background
While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients’ quality of life. This study aimed to develop a treatment for inflammatory ulcers as one of the side effects of afatinib (Giotrif®), a second-generation EGFR-TKI, and established a skin disorder mouse model to investigate the protective effect of minocycline.

Methods
First, under inhalation anesthesia with isoflurane, the back of a male ddy mouse was shaved, and afatinib petrolatum was applied alone or in combination with minocycline to observe the state of the skin and measure transepidermal water transpiration (TEWL). Next, afatinib was administered orally to mice, and minocycline petrolatum was applied to observe whether the skin disorder was prevented and its effect on repair of the skin disorder.

Results
Skin injury occurred on the back of the mouse following afatinib (1 mg/g in petrolatum) application, and scab formation was observed. Application of minocycline prevented and improved the skin disorder caused by afatinib. When the minocycline-petrolatum mixture was applied to the mouse that developed the skin disorder, a significant improvement in TEWL was observed, and skin repair was observed macroscopically.

Conclusions
These results suggest that minocycline petrolatum applied locally prevents and repairs afatinib-induced skin disorders of non-small cell lung cancer patients. Histological examination of skin has provided insights into the mechanism of the occurrence of afatinib-related skin disorder and suggested the efficacy of minocycline topical application in clinical practice.
TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription
Authors: Wang Guangyu , Meng Qingshu , Xia Bo , Zhang Shuo , Lv Jie , Zhao Dongyu , Li Yanqiang , Wang Xin , Zhang Lili , Cooke John P. , Cao Qi , Chen Kaifu 
Published: April 2020

AbstractWe present TADsplimer, the first computational tool to systematically detect topologically associating domain (TAD) splits and mergers across the genome between Hi-C samples. TADsplimer recaptures splits and mergers of TADs with high accuracy in simulation analyses and defines hundreds of TAD splits and mergers between pairs of different cell types, such as endothelial cells and fibroblasts. Our work reveals a key role for TAD remodeling in epigenetic regulation of transcription and delivers the first tool for the community to perform dynamic analysis of TAD splits and mergers in numerous biological and disease models.
ERP and oscillatory differences in overweight/obese and normal-weight adolescents in response to food stimuli
Authors: Biehl Stefanie C. , Keil Julian , Naumann Eva , Svaldi Jennifer 
Published: April 2020

Abstract
Background
Findings are mixed regarding the association of electroencephalographic (EEG) attentional bias measures and body weight, with few studies measuring food craving or intake and no study reporting oscillatory measures.

Methods
EEG data were collected while 28 satiated adolescents (14 overweight/obese) viewed pictures of neutral, low-calorie food, and high-calorie food stimuli and rated their desire to eat, before having access to high-calorie snacks.

Results
Unlike normal-weight adolescents, overweight/obese participants showed similar P300 amplitudes for high- and low-calorie food, and strongest event-related alpha band desynchronization for low-calorie stimuli. P300 amplitudes and state craving for low-calorie food furthermore predicted snack intake in this group.

Conclusions
The current research focus in overweight/obesity might need to be extended to include low-calorie food. While all participants showed an attentional bias for high-calorie food, it was the processing of low-calorie food which distinguished the two weight groups on measures of neural activity and which was associated with snack food intake in the overweight/obese group.
The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: A case control study
Authors: Chang Ning-Chia , Yang Hua-Ling , Dai Chia-Yen , Lin Wen-Yi , Wang Hsun-Mo , Chien Chen-Yu , Ho Kuen-Yao 
Published: April 2020

Background Age-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with ARHI. The aim of this study is to analyze the associations of single nucleotide polymorphisms (SNPs) of IL-1 receptor genes with ARHI in an elderly population in Taiwan. Method Participants ≥65 years of age were recruited for audiometric tests and genetic analyses. The bilateral pure-tone average (PTA) of high-tone hearing levels was calculated for ARHI evaluation. The associations of SNPs of the IL-1 receptor type 1 gene (IL1R1) (rs3917225 and rs2234650) and type 2 gene (IL1R2) (rs4141134 and rs2071008) with ARHI were analyzed in 182 ARHI-susceptible (case) and 176 ARHI-resistant (control) participants. Results The G allele of IL1R1 rs3917225 showed a decreased risk of ARHI after adjustments for sex, age, and noise exposure. The GG genotype of IL1R1 rs3917225 in all hereditary models and the TT genotype of IL1R2 rs2071008 in the recessive model also showed decreased risks of ARHI after adjustments. Conclusion These findings suggest that IL1R1 and IL1R2 polymorphisms may contribute to the decreased risk of ARHI in the elderly population.
Evaluation of the value of the VI-RADS scoring system in assessing muscle infiltration by bladder cancer
Authors: Wang Ziyong , Shang Yunyun , Luan Ting , Duan Yi , Wang Jiansong , Wang Haifeng , Hao Jingang 
Published: April 2020

Abstract
Background
The Vesical Imaging-Reporting and Data System (VI-RADS) was created in 2018, and a 5-point VI-RADS scoring system was proposed to determine whether the muscularis of the bladder has been infiltrated by tumor tissues.

Purpose
To verify the accuracy of the VI-RADS scoring system in predicting muscle-invasive bladder cancer and to explore its value in clinical application.

Materials and methods
A total of 220 patients with bladder cancer who underwent multiparameter magnetic resonance imaging from January 2017 to June 2019 were selected. Then, two radiologists with equivalent qualifications gave their diagnoses of bladder tumors on T2-weighted imaging, diffusion-weighted imaging and dynamic contrast enhanced imaging. Meanwhile, the bladder tumor was also scored on the basis of the VI-RADS system; for multifocal tumors, the highest tumor load was selected for scoring. Furthermore, the final pathological results of the patients were unknown during the imaging diagnosis and scoring. Next, the VI-RADS score was compared with the pathological results after surgery, and the ability of the VI-RADS score to assess the degree of muscularis infiltration was finally analyzed.

Results
A total of 220 patients were included in our study, including 194 males and 26 females. Among them, the pathological results were 113 cases of muscle-invasive bladder cancer and 107 cases of non-muscle-invasive bladder cancer. The results showed that there was a positive correlation between the pathological results and VI-RADS score (r = 0.821, P < 0.05). The area under the receiver operating characteristic curve of the VI-RADS score was 0.960 (95% CI: 0.937, 0.983). When the VI-RADS score was above 3, the sensitivity, specificity and accuracy of predicting muscle-invasive bladder cancer were 82.3, 95.3 and 88.64%, respectively.

Conclusion
The VI-RADS scoring system has good diagnostic value in predicting the degree of tumor invasion and can be used to guide clinical decision-making and management.
The role of brain structural magnetic resonance imaging in the assessment of hippocampal subfields in Alzheimer’s disease
Authors: Saad Sameh Hany Sobhy , Alashwah Mohammad Mahmoud Alhousini , Alsafa Ashraf Abo , Dawoud Mahmoud A. 
Published: April 2020

Abstract
Background
Volumetric MR neuroimaging can visualize the pattern of hippocampal subfield atrophic changes in AD. This can be used as a biomarker in early diagnosis of AD and allow early treatment to improve memory, behavioral symptoms, and delay the cognitive deterioration. The aim of this work is to assess the role of the volumetric study of different hippocampal subfields as a post-processing technique of structural MR imaging in patients with Alzheimer’s disease of different severity of cognitive functions. The regional ethics committee approved the study and written informed consent was obtained from all participants. In the duration from 2016 to 2018, a cross-sectional study was conducted on 30 patients (17 males and 13 females) and 15 healthy elderly controls (9 males and 6 females) referred to the Radiodiagnosis Department from the Neuropsychiatry Department. Patients were diagnosed with AD by clinical examination and using the Mini Mental State Examination (MMSE) and the Clinical Dementia Rating scale (CDR) as a measure of general cognitive performance.

Results
CA1 and subiculum subfields were significantly reduced in size in patients with Alzheimer’s disease in relation to the age-matched control group (P < 0.05). This finding was positively correlated with the MMSE score and negatively correlated with CDR clinical tests. No significant atrophy was found among other hippocampal subfields in the patients’ group.

Conclusion
This study proposed a new approach to detect atrophy in hippocampal subfields, using MR volumetric study of high-resolution T1 images, that can be used as a biomarker in the diagnosis of AD patients and differentiating them from elderly control subjects which is important in early diagnosis of AD and hence the proper treatment to improve the prognosis of the cognitive function.
Lower extremity arterial calcifications assessed by multislice CT as a correlate to coronary artery disease
Authors: Aly Gamal Samir Gamal , Kassem Hussien Heshmat , Hashad Assem , Salem Mohammad Ali , Labib Dina , Baligh Essam 
Published: April 2020

Abstract
Background
Patients with peripheral artery disease (PAD) frequently have concomitant coronary artery disease (CAD) and display a higher risk for myocardial infarction, stroke, and death due to cardiovascular events. In order to prevent cardiovascular events, there is an increasing interest in new markers of atherosclerosis. Vascular calcifications (VC) are often present in the early stages of atherogenesis and could be considered an early marker. The aim of this study is to correlate the extent of lower limbs, aortic, and coronary arterial calcification diagnosed by non-contrast multislice CT with the severity of coronary artery disease diagnosed by conventional coronary angiography.

Results
There is borderline significant association between CAD (Gensini score) and each of total lower limb and aorto-iliac calcifications. There is significant association between the number of diseased coronaries and lower limb calcifications. Also, there is significant association between the coronary artery calcifications and lower limb arterial calcifications (total and segmental).
Diabetes mellitus and hypertension are significantly associated with lower limb calcification (total, aorto-iliac, and infra-popliteal). Moreover, lower limb arterial calcifications (total and segmental) are positively correlated with increasing age.

Conclusion
Lower limb arterial calcifications, as diagnosed by non-contrast MSCT, is a noninvasive measure for evaluation of the atherosclerotic burden that correlate to the CAD; it can aid to refine risk stratification and the need for more aggressive preventive strategies.
Incidence of Anaphylaxis to Sugammadex in a Single-Center Cohort of 19,821 Patients
Authors: Burbridge Mark A. 
Published: April 2020

Background:
Sugammadex is a modified cyclodextrin that is being increasingly used in anesthetic practice worldwide for the reversal of the aminosteroid neuromuscular blockers rocuronium and vecuronium. Its safety profile, however, is incompletely understood. One such aspect is the incidence of anaphylactic reactions that occur after its administration. While several case reports exist in the literature, there is a paucity of information on the actual incidence of anaphylactic reactions.

METHODS:
A single-center retrospective chart review identified patients who experienced anaphylaxis to sugammadex in the institutional electronic medical record system. These charts were then reviewed to determine whether the etiology of anaphylaxis was sugammadex administration.

RESULTS:
Two patients experienced anaphylaxis to sugammadex, which occurred in a single institution cohort of 19,821 patients who received 23,446 total doses. This rate is markedly lower than the 1/300 that the manufacturer’s package insert states and also lower than the 1/2500 that the only other large cohort study performed has reported.

CONCLUSIONS:
The incidence of anaphylaxis to sugammadex in this cohort of patients was 2 of 19,821 patients, who received a total of 23,446 doses.
Global trends in indications for total elbow arthroplasty: a systematic review of national registries
Authors: Macken Arno A. , Prkic Ante , Kodde Izaäk F. , Lans Jonathan , Chen Neal C. , Eygendaal Denise 
Published: April 2020

National registries provide useful information in understanding outcomes of surgeries that have late sequelae, especially for rare operations such as total elbow arthroplasty (TEA). A systematic search was performed and data were compiled from the registries to compare total elbow arthroplasty outcomes and evaluate trends. We included six registries from Australia, the Netherlands, New Zealand, Norway, the United Kingdom and Sweden. Inflammatory arthritis was the most common indication for total elbow arthroplasty, followed by acute fracture and osteoarthritis. When comparing 2000–2009 to 2010–2017 data, total elbow arthroplasty for inflammatory arthritis decreased and total elbow arthroplasty for fracture and osteoarthritis increased. There was an increase in the number of revision TEAs over this time period. The range of indications for total elbow arthroplasty is broadening; total elbow arthroplasty for acute trauma and osteoarthritis is becoming increasingly more common. However, inflammatory arthritis remains the most common indication in recent years. This change is accompanied by an increase in the incidence of revision surgery. Cite this article: EFORT Open Rev 2020;5:215-220. DOI: 10.1302/2058-5241.5.190036
Mitochondrial DNA control region diversity in Common Terns Sterna hirundo from Slovenia and Croatia
Authors: Svetličić Ida , Kralj Jelena , Martinović Miloš , Tome Davorin , Basle Tilen , Božić Luka , Škornik Iztok , Jurinović Luka , Galov Ana 
Published: April 2020

Abstract
63 Common Tern Sterna hirundo samples from Croatia and Slovenia were analysed with respect to their genetic diversity and differentiation. Samples originated from two freshwater populations (areas of the rivers Sava and Drava) and one coastal population (Sečovlje Salina). The molecular marker of choice was 709 bp long fragment of the mitochondrial control region, the fastest-evolving part of the mitochondrial genome. 21 haplotypes with 12 polymorphic sites were identified. Overall haplotype diversity was substantial and estimated at 0.8599, while the overall nucleotide diversity was low and estimated at 0.0025. Diversity indices were highest for the Drava population, followed by the Sava and the lowest for the Sečovlje population. Overall genetic structure was significantly low (Fst=0.0377) and attributed to the differences in haplotype frequencies between the populations. The high level of genetic diversity found in continental populations illustrates the importance of their habitats as reservoirs of genetic diversity and calls for their further protection and management.
Експериментальні дослідження транспортного абсорбційного холодильного приладу
Authors: Очеретяний Ю. О. , Тітлов О. С. 
Published: April 2020

Транспортні холодильні пристрої є невід’ємною частиною ланцюга безперервного холодильного обладнання та незамінні для туристів, мисливців та експедиційних працівників. Сучасні аналоги стиснення та термоелектрики транспортних абсорбційних холодильних пристроїв працюють від генераторів електроенергії або від акумуляторних батарей, що призводить до збільшення ваги автомобіля і, зрештою, до додаткових витрат палива. Актуальність досліджень транспортних абсорбційних х холодильних пристроїв пов'язана насамперед з можливістю їх роботи з неелектричними джерелами теплової енергії – пальними елементами. У пальниковому елементі 100% енергії згоряння викопного палива безпосередньо перетворюється на теплову енергію. При цьому коефіцієнт корисної дії сучасних генераторів електричної енергії не перевищує 20%. Тем не менш, для широкого використання транспортних абсорбційних холодильних пристроїв необхідно вживати заходів щодо зменшення споживання енергії, що сприятливо позначиться на вагових параметрах транспортного засобу. Через складність побудови тео­ретичних моделей експериментальним методом було обрано основний метод дослідження транспортних абсорбційних холодильних пристроїв. Об’єктом експериментальних досліджень став транспортний абсорбційний холодильний прилад «Київ» виробництва Васильківського холодильного заводу. У пальному елементі завдяки установці спеціального керамічного елемента каталізатора газ окислюється атмосферним киснем на поверхні каталізатора. Конструкція пальника дозволяє створити якісну суміш повітря-газ і рівномірно розподілити полум'я по всій поверхні каталізатора. Експериментальні дослідження показали, що: а) при роботі з етиловим спиртом і гасом необхідні умови охолодження досягаються в холодильнику; б) при рівних робочих умовах відсутність турбулайзера потоку продуктів згоряння у вентиляційному каналі генератора не дозволяє забезпечити необхідні режими охолодження. Для посилення режимів охолодження тепловіддаючих елементів холодильника (абсорбера та конденсатора) було проведено ряд експериментів із продуванням за допомогою повітряного вентилятора. При низьких температурах навколишнього середовища (16-21 ºС) ефект зовнішнього охолодження прак­тично непомітний – падіння температур в холодильній камері становить 0,8-1,2 ºС, при температурі 22-26 ºС ефект досягає 2,6 ºС, а при 30-33 ºС – 5,3 ºС
Protección de los derechos de las familias residentes en el barrio La Paz de Barranquilla, año 2010
Authors: Álvarez Pertuz Alicia 
Published: April 2020

El presente artículo de refl exión tiene como fi nalidad efectuar un estudio y evaluación acerca de los organismos de orden público y privado encargados de la protección de la familia como célula fundamental de la sociedad. En consideración a lo anterior, el Constituyente de 1991 consagró el derecho que le asiste a toda persona a tener una familia y la protección constitucional que esta merece como núcleo esencial de la sociedad. Especial énfasis se da a la necesidad de mantener la armonía y la unidad familiar, fundamento de la convivencia social y de la paz. Para lograr este cometido el Estado cuenta con diversos programas, políticas y organismos especializados, donde cada uno de ellos ejecuta unos planes específi cos tendientes a proteger a la familia y a sus miembros, proporcionándoles los medios para su desarrollo integral, en virtud de lo cual se investigará si los organismos encargados de ejecutar esta labor los aplican y hacen efectivos respecto a los habitantes del barrio La Paz de la ciudad de Barranquilla durante el año 2010.
Perspectivas y retos del sistema jurídico en Colombia. Una mirada al precedente constitucional como tendencia anti-formal y obligatoria
Authors: Palencia Ramos Eduardo Antonio 
Published: April 2020

Este artículo de reflexión tiene como objetivo fundamental la contribución al ya dilatado y, siempre sustancial, debate referente al precedente constitucional, cuyo valor estriba en la consecución de un ordenamiento normativo signado por la función creadora del operador judicial. Surge entonces, como intención primera, el exhibir al precedente como fuente del Derecho y como tendencia antiformal que permite así mismo lograr la superación del sistema legalista, característico en los países de tradición jurídica continental europea. Por consiguiente se considera que la irrupción de la figura del precedente generó beneficios al Derecho colombiano, puesto que la igualdad y la coherencia son pilares esenciales en todo ordenamiento jurídico. Los conceptos emanados pretenden ser parte de la controversia jurídica nacional en torno al tema en cuestión, vista esta como único medio que le permite al estudioso de la ciencia jurídica, incrementar su cognición y ser partícipe propositivo del Derecho.

AbstractThis article’s main purpose reflection contribution to the already lengthy and always substantive debate concerning the constitutional precedent , whose value lies in achieving a regulatory system marked by the creative function of the judicial operator. Then arises as a first intention, the previous display as a source of law and as antiformal trend likewise allows overcoming achieve characteristic in countries of European continental legal tradition legalistic system. Therefore it is considered that the emergence of the figure of the previous generated benefits to Colombian law, since equality and consistency are essential pillars in all laws. The concepts emanating intended to be part of the national legal controversy surrounding the issue at hand, view this as the only way that allows the student of legal science, increase cognition and be proactive part right.
Três poemas de futebol
Authors: Carmona Kaio 
Published: April 2020

Nestes três poemas, sem título, "Desmedida" e "Uma e outra", Caio Karmona liga o futebol ao erotismo (ludos e eros), não definindo precisas regras entre o jogo da bola e o jogo erótico, porque ambos movidos pelo prazer – “Se a uma me entrego nos carinhos / de mesa e cama, à outra me dou / nos fins de semana”.
O futebol brasileiro e a constituição de sujeitos trans: sob as lentes do cronotopo bakhtiniano
Authors: Marques Garcia Rafael , Fernandes de Santana Wilder Kleber 
Published: April 2020

O presente trabalho delimitou como categoria para subsidiar a pesquisa o cronotopo, termo bakhtiniano que diz respeito a estudos literários e éticos (da cultura humana). Para tanto, fizemos um estudo sobre a constituição de sujeitos trans no futebol contemporâneo brasileiro, em que é preciso recorrer à História, reenunciando dizeres de Platão, Aristóteles dentre outros. O objetivo de nosso trabalho consiste em analisar a constituição de sujeitos trans no futebol contemporâneo brasileiro sob as lentes do cronotopo bakhtiniano, e isso nos impulsionou a traçar processos de (des)naturalização das concepções de sujeito no tempo e no espaço. Em aspectos temáticos, o presente manuscrito aborda o cronotopo e sua implicação para repensar o futebol e os sujeitos trans no futebol contemporâneo brasileiro, situando esse esporte enquanto um importante espaço histórico e simbólico, onde são perceptíveis mudanças nos sujeitos.