bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple limbal epithelial transplantation: Current status and future perspectives
Authors: Jackson Catherine J. , Myklebust Ernø Inger T. , Ringstad Håkon , Tønseth Kim A. , Dartt Darlene A. , Utheim Tor P. 
Published: December 2019

AbstractDamage to limbal stem cells as a result of injury or disease can lead to limbal stem cell deficiency (LSCD). This disease is characterized by decreased vision that is often painful and may progress to blindness. Clinical features include inflammation, neovascularization, and persistent cornea epithelial defects. Successful strategies for treatment involve transplantation of grafts harvested from the limbus of the alternate healthy eye, called conjunctival-limbal autograft (CLAU) and transplantation of limbal cell sheets cultured from limbal biopsies, termed cultured limbal epithelial transplantation (CLET). In 2012, Sangwan and colleagues presented simple limbal epithelial transplantation (SLET), a novel transplantation technique that combines the benefits of CLAU and CLET and avoids the challenges associated with both. In SLET a small biopsy from the limbus of the healthy eye is divided and distributed over human amniotic membrane, which is placed on the affected cornea. Outgrowth occurs from each small explant and a complete corneal epithelium is typically formed within 2 weeks. Advantages of SLET include reduced risk of iatrogenic LSCD occurring in the healthy cornea at harvest; direct transfer circumventing the need for cell culture; and the opportunity to perform biopsy harvest and transplantation in one operation. Success so far using SLET is comparable with CLAU and CLET. Of note, 336 of 404 (83%) operations using SLET resulted in restoration of the corneal epithelium, whereas visual acuity improved in 258 of the 373 (69%) reported cases. This review summarizes the results of 31 studies published on SLET since 2012. Progress, advantages, challenges, and suggestions for future studies are presented.Significance statement The present review examines work reporting simple limbal epithelial transplantation (SLET), an innovative technique that uses minimal limbal tissue from the healthy eye to regenerate the cornea in the limbal deficient diseased eye. Results since the introduction of SLET in 2012 suggest that the success rate is comparable to established techniques, conjunctival-limbal autograft and cultured limbal epithelial transplantation. However, SLET has the advantages of requiring a smaller biopsy, achieving harvest and transplantation in a single operation, and the unnecessity of cell culture laboratories. AlloSLET, a novel modification of SLET using allogeneic tissue, promises to further improve outcome through promotion of early resolution of inflammation in the injured/diseased eye.
Cu(NO3)2/Oxone‐Mediated Radical Nitration Cyclization of 1,6‐Enynes
Authors: Song Si‐Zhe , Kang Qing‐Qing , Cao Ting‐Ting , Lei Ke‐Wei , Liu Yan‐Yun , Li Qiang , Wei Wen‐Ting 
Published: December 2019

AbstractHerein we report a protocol for commercial available oxone‐mediated nitration cyclization between 1,6‐enynes and Cu(NO3)2. This strategy shows attractive characteristics such as mild reaction conditions, operational simplicity, broad substrates scope with good to excellent yields and high functional group tolerance. The reaction provides a regioselective way toward the formation of a new C−N and C−C bonds in one step. Mechanistic studies reveal that the procedure undergoes a radical process.
Identification and Screening of Selective WEE2 Inhibitors to Develop Non‐Hormonal Contraceptives that Specifically Target Meiosis
Authors: Hanna Carol B. , Yao Shan , Martin Mat , Schönbrunn Ernst , Georg Gunda I. , Jensen Jeffrey T. , Cuellar Rebecca A. D. 
Published: December 2019

AbstractWe used a progressive elimination strategy to identify oocyte‐specific WEE2 kinase inhibitors for potential non‐hormonal contraceptives that target meiosis. Beginning with an in‐house library of over 300,000 compounds, virtual high throughput screening identified 57 WEE2 inhibitors with preferential predicted binding over the somatic variant WEE1. Seven compounds were further evaluated in vitro by enzyme‐linked immunosorbent assay to measure biochemical inhibition on WEE1 and WEE2 phosphorylation of CDK1. To assess specificity, we evaluated WEE2‐mediated inhibition of meiosis using in vitro oocyte fertilization, and WEE1‐mediated inhibition of mitosis using a somatic cell proliferation assay. Our results from these assays identified three candidates for further development: 6‐(2,6‐dichlorophenyl)‐2‐((4‐(2‐(diethylamino)ethoxy) phenyl)amino)‐8‐methylpyrido[2,3‐d]pyrimidin‐7(8H)‐one (2), 6‐(2,6‐dichlorophenyl)‐8‐methyl‐2‐((4‐morpholinophenyl)amino)pyrido[2,3‐d]pyrimidin‐7(8H)‐one (12), and 3‐((6‐(2,6‐dichlorophenyl)‐8‐methyl‐7‐oxo‐7,8‐dihydropyrido[2,3‐d]pyrimidin‐2‐yl)amino)benzoic acid (16).
Understanding the Mechanism of Nitrobenzene Nitration with Nitronium Ion: A Molecular Electron Density Theory Study
Authors: Cyrille Nana Nouhou , Idrice Adjieufack Abel , Maraf Mbah Bake , Charles Fon Abi , Ibrahim Mbouombouo Ndassa , Ríos‐Gutierrez Mar , Domingo Luis Ramon 
Published: December 2019

AbstractThe nitration reaction of nitrobenzene with nitronium ion yielding ortho‐, meta‐ and para‐dinitrobenzenes has been studied within the Molecular Electron Density Theory, using DFT computational methods at the B3LYP/6‐311G(d,p) level. This electrophilic aromatic substitution (EAS) reaction takes place through a two‐step mechanism involving the formation of a tetrahedric cation intermediate. The electrophilic attack of nitronium ion on nitrobenzene is the rate‐determining step of this EAS reaction, and consequently, responsible for the composition of the reaction mixture. The subsequent proton abstraction from the cation intermediate is barrierless. From the computed activation Gibbs free energies, a relationship 11.0 (ortho) : 87.3 (meta) : 1.7 (para) of the dinitrobenzenes is estimated, in clear agreement with the experimental outcome. The similar nucleophilic activation of the ortho and meta carbons of nitrobenzene makes it possible to question the hypothesis for the orientation in EAS reactions involving nucleophilically deactivated benzenes based on the relative stability of the tetrahedric cation intermediates.
Biodegradable Bi2O2Se Quantum Dots for Photoacoustic Imaging‐Guided Cancer Photothermal Therapy
Authors: Xie Hanhan , Liu Mingqiang , You Baihao , Luo Guanghong , Chen Yue , Liu Bilu , Jiang Zhenyou , Chu Paul K. , Shao Jundong , Yu Xue‐Feng 
Published: December 2019

AbstractAs new 2D layered nanomaterials, Bi2O2Se nanoplates have unique semiconducting properties that can benefit biomedical applications. Herein, a facile top‐down approach for the synthesis of Bi2O2Se quantum dots (QDs) in a solution is described. The Bi2O2Se QDs with a size of 3.8 nm and thickness of 1.9 nm exhibit a high photothermal conversion coefficient of 35.7% and good photothermal stability. In vitro and in vivo assessments demonstrate that the Bi2O2Se QDs possess excellent photoacoustic (PA) performance and photothermal therapy (PTT) efficiency. After systemic administration, the Bi2O2Se QDs accumulate passively in tumors enabling efficient PA imaging of the entire tumors to facilitate imaging‐guided PTT without obvious toxicity. Furthermore, the Bi2O2Se QDs which exhibit degradability in aqueous media not only have sufficient stability during in vivo circulation to perform the designed therapeutic functions, but also can be discharged harmlessly from the body afterward. The results reveal the great potential of Bi2O2Se QDs as a biodegradable multifunctional agent in medical applications.
Viable system function and construction design methodology
Authors: Mouhib Nora , Bah Slimane , Berrado Abdelaziz 
Published: December 2019

AbstractIn this paper, the authors propose a new methodology relative to earlier work on the Viable System Ontology Theory. This theory links Beer's Viability theory and Dietz's Performance in Social Interaction (PSI) theory and aims at supporting the business process design of a viable system. This work extends the Viable System Ontology Theory by a detailed methodology that alternates the VSM functional diagnosis and design with the construction design as recommended by the Generic System Development Process (GSDP). The proposed methodology consists of three iterative phases: the environment construction, the function design, and the construction design of a viable system. Those steps are discussed in the light of the Viable System Ontology Theory propositions. In addition, they are illustrated by the case study of the Moroccan public medicine procurement system.
Quantum tunnelling, real-time dynamics and Picard-Lefschetz thimbles
Authors: Mou Zong-Gang , Saffin Paul M. , Tranberg Anders 
Published: December 2019

Abstract
We follow up the work, where in light of the Picard-Lefschetz thimble approach, we split up the real-time path integral into two parts: the initial density matrix part which can be represented via an ensemble of initial conditions, and the dynamic part of the path integral which corresponds to the integration over field variables at all later times. This turns the path integral into a two-stage problem where, for each initial condition, there exits one and only one critical point and hence a single thimble in the complex space, whose existence and uniqueness are guaranteed by the characteristics of the initial value problem. In this paper, we test the method for a fully quantum mechanical phenomenon, quantum tunnelling in quantum mechanics. We compare the method to solving the Schrödinger equation numerically, and to the classical-statistical approximation, which emerges naturally in a well-defined limit. We find that the Picard-Lefschetz result matches the expectation from quantum mechanics and that, for this application, the classical-statistical approximation does not.
On one loop corrections in higher spin gravity
Authors: Ponomarev Dmitry , Sezgin Ergin , Skvortsov Evgeny 
Published: December 2019

Abstract
We propose an approach to compute one-loop corrections to the four-point amplitude in the higher spin gravities that are holographically dual to free O(N), U(N) and USp(N) vector models. We compute the double-particle cut of one-loop diagrams by expressing them in terms of tree level four-point amplitudes. We then discuss how the remaining contributions to the complete one-loop diagram can be computed. With certain assumptions we find nontrivial evidence for the shift in the identification of the bulk coupling constant and 1/N in accordance with the previously established result for the vacuum energy.
Reevaluating uncertainties in $$ \overline{B} $$ → Xsγ decay
Authors: Gunawardana Ayesh , Paz Gil 
Published: December 2019

Abstract
The rare decay $$ \overline{B} $$

B
¯

→ Xsγ is an important probe of physics beyond the standard model. The largest uncertainty on the total rate and the CP asymmetry arises from resolved photon contributions. These appear first at order 1/mb and are related to operators other than Q7γ in the effective weak Hamiltonian. One of the three leading contributions, $$ {Q}_1^q-{Q}_{7\gamma } $$

Q
1
q

−

Q

7
γ

, is described by a non-local function whose moments are related to HQET parameters. We use recent progress in our knowledge of these parameters to reevaluate the resolved photon contribution to $$ \overline{B} $$

B
¯

→ Xsγ total rate and CP asymmetry.
Seesaw neutrinos with one right-handed singlet field and a second Higgs doublet
Authors: Jurčiukonis D. , Gajdosik T. , Juodagalvis A. 
Published: December 2019

Abstract
We study parameters of an extension of the Standard Model. The neutrino sector is enlarged by one right-handed singlet field, allowing for the seesaw mechanism type-I, and the Higgs sector contains one additional doublet, which contributes to light neutrino masses through one-loop radiative corrections. Employing an approximation for the effective light neutrino mass matrix we express the masses of the light neutrinos analytically, allowing us to parameterize the Yukawa couplings to neutrinos by the experimental measurements on the neutrino sector and only two free parameters. We focus on a CP-conserving Higgs potential for which we present the allowed ranges of the input parameters and a statistical overview over the possible values of the Yukawa couplings.
Phenomenology of GeV-scale scalar portal
Authors: Boiarska Iryna , Bondarenko Kyrylo , Boyarsky Alexey , Gorkavenko Volodymyr , Ovchynnikov Maksym , Sokolenko Anastasia 
Published: December 2019

Abstract
We review and revise the phenomenology of the scalar portal — a new scalar particle with the mass in GeV range that mixes with the Higgs boson. In particular, we consider production channels B → SK1(1270) and $$ B\to S{K}_0^{\ast }(700) $$
B
→
S

K
0
∗

700

and show that their contribution is significant. We extend the previous analysis by comparing the production of scalars from decays of mesons, of the Higgs bosons and direct production via proton bremsstrahlung, deep inelastic scattering and coherent scattering on nuclei. Relative efficiency of the production channels depends on the energy of the beam and we consider the energies of DUNE, SHiP and LHC-based experiments. We present our results in the form directly suitable for calculations of experimental sensitivities.
Special Galileon at one loop
Authors: Přeučil Filip , Novotný Jiří 
Published: December 2019

Abstract
We present a complete one-loop renormalization of the Special Galileon S­matrix. Especially, we give a complete list of the higher derivative operators which are necessary for the one-loop on-shell renormalization and prove the invariance of the one­loop on-shell effective action with respect to the Special Galileon symmetry. This enables us to enlarge the validity of the enhanced O(p3) soft behavior of the scattering amplitudes to the one-loop level. As an illustration, we discuss explicitly the four-point and five-point one-loop scattering amplitudes and comment on some conjectures appearing in the existing literature.
Hexagons and correlators in the fishnet theory
Authors: Basso Benjamin , Caetano João , Fleury Thiago 
Published: December 2019

Abstract
We investigate the hexagon formalism in the planar 4d conformal fishnet theory. This theory arises from $$ \mathcal{N} $$
N
= 4 SYM by a deformation that preserves both conformal symmetry and integrability. Based on this relation, we obtain the hexagon form factors for a large class of states, including the BMN vacuum, some excited states, and the Lagrangian density. We apply these form factors to the computation of several correlators and match the results with direct Feynman diagrammatic calculations. We also study the renormalisation of the hexagon form factor expansion for a family of diagonal structure constants and test the procedure at higher orders through comparison with a known universal formula for the Lagrangian insertion.
On the phenomenology of sphaleron-induced processes at the LHC and beyond
Authors: Papaefstathiou Andreas , Plätzer Simon , Sakurai Kazuki 
Published: December 2019

AbstractWe investigate the phenomenological aspects of non-perturbative baryon- and lepton-number-violating processes at hadron colliders. Such processes, induced by instan- ton/sphaleron configurations of the electroweak gauge fields, are believed to play a crucial role in the generation of baryon asymmetry in the early Universe at finite temperature. On the other hand, at colliders (that represent the zero-temperature high-energy regime) the rate and observability of such processes are still under debate. Motivated by current the- oretical considerations, we construct a modern event generator within the general-purpose Herwig Monte Carlo framework, that aims to capture the most relevant features of the dominant processes. We perform a detailed phenomenological analysis focussing on the Large Hadron Collider, at 13 TeV proton-proton centre-of-mass energy, a potential high- energy upgrade at 27 TeV and the proposed Future Circular Collider (FCC-hh) at 100 TeV. We derive constraints on the expected rates for various parametrisations of our model. We find that all three colliders are capable of providing meaningful information on the nature of instanton/sphaleron-induced processes at various energy scales.
Inequalities for Some Integrals Involving Modified Lommel Functions of the First Kind
Authors: Gaunt Robert E. 
Published: December 2019

AbstractIn this paper, we obtain inequalities for some integrals involving the modified Lommel function of the first kind$$t_{\mu ,\nu }(x)$$tμ,ν(x). In most cases, these inequalities are tight in certain limits. We also deduce a tight double inequality, involving the modified Lommel function$$t_{\mu ,\nu }(x)$$tμ,ν(x), for a generalized hypergeometric function. The inequalities obtained in this paper generalise recent bounds for integrals involving the modified Struve function of the first kind.
PTPN11 mutation with additional somatic alteration indicates unfavorable outcome in juvenile myelomonocytic leukemia: a retrospective clinical study from a single center
Authors: Miao Yan , Li Benshang , Ding Lixia , Zhu Hua , Luo Changying , Wang Jianmin , Luo Chengjuan , Chen Jing 
Published: December 2019

AbstractJuvenile myelomonocytic leukemia (JMML) is a heterogeneous childhood leukemia. The management of patients with JMML requires accurate assessment of genetic and clinical features to help in patient risk stratification. This study aimed to investigate the association between genomic alterations and prognosis in children with JMML. Genomic DNA was extracted from a total of 93 patients with JMML for targeted sequencing. Univariable and multivariable analysis were used to evaluate the correlation between gene mutations and prognosis of the patients. Patients withPTPN11mutation exhibited significantly lower event-free survival (EFS) compared with non-PTPN11mutations (P = 0.005). Patients without or with one somatic alteration at diagnosis showed significantly better prognosis in comparison with those with more than two alterations (P = 0.009).PTPN11mutation with additional alterations showed significantly the poorest outcome in comparison with those with only one non-PTPN11mutation, only onePTPN11mutation, and combined mutations withoutPTPN11, respectively (P < 0.0001).Conclusion: BothPTPN11mutation and the number of somatic alterations detected at diagnosis are likely to be the major determinant of outcome in JMML. The subgroup of patients withPTPN11mutation showed the shortest survival which was even worsened when a secondary mutation was present.
Workplace happiness, well-being and their relationship with psychological capital: A study of Hungarian Teachers
Authors: Kun Agota , Gadanecz Peter 
Published: December 2019

AbstractHappiness and well-being at work has been an increasingly popular topic in the past two decades in academic and business contexts alike, along with positive psychology, through which organizations aim to find out, what makes working environments engaging and motivating. Few studies have focused on education, however, especially from a solution-focused perspective, even though it is a sector where employees are highly exposed to stress and burnout. Accordingly, the purpose of his study was to investigate the relationship between teachers’ psychological resources through the concept of psychological capital, workplace well-being and perceived workplace happiness. We used both qualitative (open-ended question) and quantitative (test battery) methods to examine the relation between the various factors. Content analysis of responses in our qualitative research suggests that the main pillars of teachers’ workplace happiness were realization of goals, feedback, finding meaning in work and social relationships. The results of our quantitative study indicated that workplace well-being and happiness correlated with inner psychological resources, hope and optimism in particular. We conclude that the future focus on employee well-being must take into account positive contributing factors and adopt a positively-oriented approach to promoting well-being. Suggestions for practical implications are also discussed.
Investigating the variation of the Sun’s visual shape, atmospheric refraction and Einstein’s special relativity considered
Authors: Wang Yuanxiu 
Published: December 2019

AbstractBy experimental measurements and theoretical analyses, this paper investigates the variation of the Sun’s visual shape and figures out the reasons for the variation of its shape. First, the method of image processing, the method of moments and the least-square method are combined to perform experimental measurements and calculations, and the features of the Sun’s visual shape are extracted from the photos of the Sun. Second, theoretical analyses are conducted based on atmospheric refraction and the Einstein’s special relativity theory. The relationship model is established between the zenith and azimuth angles of the Sun, the velocity of the Sun relative to the Earth, and the observation time and position; the refraction index of the atmosphere is expressed as a function of altitude and wavelength of light; an iterative algorithm is constructed to trace rays of light in the atmosphere; a set of formulas is derived to determine the contraction ratio and contraction direction of the Sun’s visual shape. Finally, the theoretical and experimental results are compared; their relative errors are less than 0.3%, which verifies the theoretical analyses. Both theoretically and experimentally, this research proves that the Sun’s visual shape is an ellipse; its shape variation mainly results from atmospheric refraction effects; and the length contraction effect of the Einstein’s special relativity also contributes a little, except at the time of sunrise and sunset.