bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eco-evo-devo and iterated learning: towards an integrated approach in the light of niche construction
Authors: Segovia-Martín José , Balari Sergio 
Published: July 2020

AbstractIn this paper we argue that ecological evolutionary developmental biology (eco-evo-devo) accounts of cognitive modernity are compatible with cultural evolution theories of language built upon iterated learning models. Cultural evolution models show that the emergence of near universal properties of language do not require the preexistence of strong specific constraints. Instead, the development of general abilities, unrelated to informational specificity, like the copying of complex signals and sharing of communicative intentions is required for cultural evolution to yield specific properties, such as language structure. We argue that eco-evo-devo provides the appropriate conceptual background to ground an account for the many interconnected genetic, environmental and developmental factors that facilitated the emergence of an organic system able to develop language through the iterated transmission of information. We use the concept of niche construction to connect evolutionary developmental accounts for sensory guided motor capacities and cultural evolution guided by iterated learning models. This integrated theoretical model aims to build bridges between biological and cultural approaches.
Structure-based inhibitor design of mutant RAS proteins—a paradigm shift
Authors: Nyíri Kinga , Koppány Gergely , Vértessy Beáta G. 
Published: July 2020

AbstractAs a member of small GTPase family, KRAS protein is a key physiological modulator of various cellular activities including proliferation. However, mutations of KRAS present in numerous cancer types, most frequently in pancreatic (> 60%), colorectal (> 40%), and lung cancers, drive oncogenic processes through overactivation of proliferation. The G12C mutation of KRAS protein is especially abundant in the case of these types of malignancies. Despite its key importance in human disease, KRAS was assumed to be non-druggable for a long time since the protein seemingly lacks potential drug-binding pockets except the nucleotide-binding site, which is difficult to be targeted due to the high affinity of KRAS for both GDP and GTP. Recently, a new approach broke the ice and provided evidence that upon covalent targeting of the G12C mutant KRAS, a highly dynamic pocket was revealed. This novel targeting is especially important since it serves with an inherent solution for drug selectivity. Based on these results, various structure-based drug design projects have been launched to develop selective KRAS mutant inhibitors. In addition to the covalent modification strategy mostly applicable for G12C mutation, different innovative solutions have been suggested for the other frequently occurring oncogenic G12 mutants. Here we summarize the latest advances of this field, provide perspectives for novel approaches, and highlight the special properties of KRAS, which might issue some new challenges.
Impact of Repeated Exposure and Cleaning on Protective Properties of Structural Firefighting Turnout Gear
Authors: Horn Gavin P. , Kerber Steve , Andrews Jessica , Kesler Richard M. , Newman Hannah , Stewart Jacob W. , Fent Kenneth W. , Smith Denise L. 
Published: July 2020

AbstractThe US fire service has become acutely aware of the need to clean PPE after fires. However, there is concern that damage from repeated cleaning may impact critical protection from fireground risk. Using a protocol that included repeated simulated fireground exposures (between 0 cycles and 40 cycles) and/or repeated cleaning with techniques common in the fire service, we found that several important protective properties of NFPA 1971 compliant turnout gear are significantly changed. Outer shell and thermal liner tear strength showed a statistically significant reduction when laundered as compared to wet or dry decontamination. Larger changes in outer shell tear strength resulted when the coat closure incorporated hook & dee clasps as compared with garments using zippered closures. Total Heat Loss was reduced for all samples that underwent any form of cleaning while Thermal Protective Performance was only increased in the gear that was laundered. These results suggest that some important protective properties of bunker gear can be decreased after repeated exposure/cleaning cycles relative to their levels when tested in a new condition. For the specific materials tested, outer shell trap tear strength in the fill direction and seam strength dropped below NFPA 1971 requirements after 40 laundering cycles. The findings for this study may have utility for setting preconditions for the measurement of certain performance properties in future editions of NFPA 1971.
A review of the physiology behind letrozole applications in infertility: are current protocols optimal?
Authors: Rose Bruce I. , Brown Samuel E. 
Published: July 2020

AbstractLetrozole is a targeted aromatase inhibitor which has primarily been used in post-menopausal women with breast cancer. Recently, it has been utilized in infertile pre-menopausal women because of its ability to enhance FSH production for ovulation induction. However, the ovarian follicle’s response to FSH is only a part of the endocrine events occurring in a developing follicle. The health of the small antral follicles is driven primarily by androgens, which contribute to granulosa cell mitosis, sensitivity to FSH, and resistance to atresia. In contrast, elevated androgens in the late antral to pre-ovulatory follicle have a negative impact on follicle health and lead to atresia and cystic follicle formation. This ovarian physiologic data suggests that current applications of letrozole to infertility may be squandering some of the primary benefits available in using letrozole to promote follicle development. Four applications of letrozole to infertility that have appeared in the medical literature are reviewed. Androgen-related benefits are reviewed and various questions put forward about how letrozole could be more effectively used to help patients in these settings.
Phytoextraction from Chromium-Contaminated Soil Using Moso Bamboo in Mediterranean Conditions
Authors: Ranieri Ezio , Tursi Angelo , Giuliano Silvia , Spagnolo Vincenzo , Ranieri Ada Cristina , Petrella Andrea 
Published: July 2020

AbstractAn experimentation has been carried out in simulated Mediterranean and tropical laboratory conditions aimed to show the Moso bamboo capability of phytoextraction chromium from contaminated soil. Electronic microscopy supported the analyses performed on soil and on the different plant tissues. A preliminary test on the bamboo has been carried out in laboratory evaluating his growth with irrigation in Mediterranean conditions (600 mm/year) and tropical conditions (1.800 mm/year). A test of the bamboo tolerance of was also carried out by measuring his growth with irrigation with a solution of 100 mg Cr/l, reporting not significant damages to the plant tissues. Subsequently chromium phytoextraction was tested highlighting that bamboo removes Cr from soil with a percentage ranging from 43% (600 mm/year) to 47.4% (1.800 mm/year) of the total content in soil. Lastly, the distribution of chromium in the different fragments of the bamboo plants has been performed. It has been shown that approx. 69% of chromium, in Mediterranean conditions, was in the rhizomes and approx. 68% in tropical conditions. A slightly higher tendency to chromium translocation to leaves has been shown in tropical conditions than in Mediterranean conditions.
Living with leg lymphedema: developing a novel model of quality lymphedema care for cancer survivors
Authors: Bowman Catharine , Oberoi Devesh , Radke Lori , Francis George J. , Carlson Linda E. 
Published: July 2020

AbstractPurposeLower-extremity lymphedema (LEL) is a lifelong consequence of cancer therapy and can lead to serious physical and psychosocial complications for many cancer survivors. However, clinical knowledge and treatment of LEL remain minimal. The purpose of this study was to integrate perspectives of lymphedema patients and healthcare providers (HCPs) on LEL to develop a novel model for quality lymphedema care.MethodsA mixed-methods approach was implemented. Standardized questionnaires and semi-structured interviews were used to assess psychosocial well-being and experiences of LEL patients. Interviews were also used to evaluate the clinical experiences of HCPs working within tumour groups associated with cancer-related LEL. Thematic analysis was used to analyse qualitative data.ResultsTwenty-two patients and eleven HCPs participated in this study. Patient QOL, generalized anxiety and depressive symptom scores revealed a complex interplay between psychosocial well-being and supportive LEL care after cancer. Three themes emerged from interviews with patients (n = 19) and HCPs (n = 11): level of lymphedema knowledge, effectiveness of rehabilitation oncology services and barriers to care.Implications for Cancer SurvivorsWe developed a novel model for quality lymphedema care that emphasizes the importance of continued physical and psychosocial support for LEL patients, while illustrating the importance of HCPs in facilitating a smooth transition for patients to LEL care after cancer treatment.
Separation of diffracted waves via SVD filter
Authors: Shen Hong-Yan , Li Qin , Yan Yue-Ying , Li Xin-Xin , Zhao Jing 
Published: July 2020

Abstract
Diffracted seismic waves may be used to help identify and track geologically heterogeneous bodies or zones. However, the energy of diffracted waves is weaker than that of reflections. Therefore, the extraction of diffracted waves is the basis for the effective utilization of diffracted waves. Based on the difference in travel times between diffracted and reflected waves, we developed a method for separating the diffracted waves via singular value decomposition filters and presented an effective processing flowchart for diffracted wave separation and imaging. The research results show that the horizontally coherent difference between the reflected and diffracted waves can be further improved using normal move-out (NMO) correction. Then, a band-rank or high-rank approximation is used to suppress the reflected waves with better transverse coherence. Following, separation of reflected and diffracted waves is achieved after the filtered data are transformed into the original data domain by inverse NMO. Synthetic and field examples show that our proposed method has the advantages of fewer constraints, fast processing speed and complete extraction of diffracted waves. And the diffracted wave imaging results can effectively improve the identification accuracy of geological heterogeneous bodies or zones.
Prospective observational study of bevacizumab combined with paclitaxel as first- or second-line chemotherapy for locally advanced or metastatic breast cancer: the JBCRG-C05 (B-SHARE) study
Authors: Yamamoto Yutaka , Yamashiro Hiroyasu , Toh Uhi , Kondo Naoto , Nakamura Rikiya , Kashiwaba Masahiro , Takahashi Masato , Tsugawa Koichiro , Ishikawa Takashi , Nakayama Takahiro , Ohtani Shoichiro , Takano Toshimi , Fujisawa Tomomi , Toyama Tatsuya , Kawaguchi Hidetoshi , Mashino Kojiro , Tanino Yuichi , Morita Satoshi , Toi Masakazu , Ohno Shinji 
Published: July 2020

Abstract
Purpose
To investigate the effectiveness and safety of bevacizumab–paclitaxel combination therapy as first- or second-line chemotherapy for HER2-negative locally advanced or metastatic breast cancer in daily clinical practice.

Methods
In this prospective multicenter observational study, bevacizumab–paclitaxel was administered at the discretion of attending physicians. Cohorts A and B had hormone receptor-positive and triple-negative breast cancer (TNBC), respectively. Primary endpoint was overall survival (OS). Multivariate analyses were conducted to identify prognostic factors.

Results
Between November 2012 and October 2014, 767 patients were enrolled from 155 institutions across Japan. Effectiveness was analyzed in 754 eligible patients (cohort A, 539; cohort B, 215) and safety in 750 treated patients (median observation period, 19.7 months). Median OS (95% CI) was 21.7 (19.8–23.6) months in eligible patients; 25.2 (22.4–27.4) months and 13.2 (11.3–16.6) months in cohorts A and B, respectively; and 24.4 (21.9–27.2) months and 17.6 (15.2–20.0) months in patients receiving first- and second-line therapy, respectively. Factors affecting OS (hazard ratio 95% CI) were TNBC (1.75, 1.44–2.14), second-line therapy (1.35, 1.13–1.63), ECOG performance status ≥ 1 (1.28, 1.04–1.57), taxane-based chemotherapy (0.65, 0.49–0.86), cancer-related symptoms (0.56, 0.46–0.68), and visceral metastasis (0.52, 0.40–0.66). Incidences of grade ≥ 3 AEs hypertension, neutropenia, peripheral neuropathy, proteinuria, and bleeding were 35.7%, 27.2%, 7.2%, 3.7%, and 0.3%, respectively.

Conclusions
In Japanese clinical practice, combined bevacizumab–paclitaxel was as effective as in previous studies. Factors that independently predicted poor prognosis in the present study are consistent with those identified previously.

Trial registration
Trial no. UMIN000009086.
First Report of the Co-occurrence of Cylindrospermopsin, Nodularin and Microcystins in the Freshwaters of Lake Victoria, Tanzania
Authors: Mchau Geofrey J. , Machunda Revocatus , Kimanya Martin , Makule Edna , Gong Yun Yun , Mpolya Emmanuel , Meneely Julie P. , Elliott Christopher T. , Greer Brett 
Published: July 2020

AbstractThere is a global concern regarding the increase of cyanotoxins in freshwater and their potential effects on human health. The existence of multiple toxins in freshwater can result in an increased risk of their bioaccumulation in humans from their ingestion through contaminated drinking water or recreational activities. This study, the first of its kind, was conducted to determine the occurrence of thirteen cyanotoxins namely; microcystins (-LA, -LF, -LR, -LY, -LW, -RR, -YR, -WR, dm MC-RR and dm MC-LR), anatoxin-a, nodularin and cylindrospermopsin in the freshwaters of Lake Victoria in Tanzania. A total of 23 sites were selected for water sampling. Samples were randomly collected from lakeshores (n = 54), wells (n = 66) and piped water (n = 18) in two phases, February (dry season) and December (rainy season) 2018. Samples (n = 138) were analysed using liquid chromatography mass spectrometry (UPLC-MS/MS). Cylindrospermopsin was the most abundant cyanotoxin detected in the lakeshores, with eight of the nine collection sites (89%) reporting cylindrospermopsin in phase I, compared to three out of nine (33%) in phase II. Microcystin congeners -RR, -LR and -YR were detected in phase I, with microcystins -RR and -LR detected in phase II. MC concentrations ranged from 0.003 to 0.007 μg/L for MC-RR, 0.01–0.013 μg/L for MC-LR and 0.004 to 0.01 μg/L for cylindrospermopsin, with nodularin reported once at a concentration of 0.01 μg/L. No cyanotoxins were detected in wells or in treated pipe water samples. The existence of multiple toxins in different collection sites may lead to synergistic effects and increase the toxicological risk to humans. This is the first study to report the presence of cylindrospermopsin and nodularin in the freshwaters of Lake Victoria.
Stationary water waves on rotational flows of two vortical layers
Authors: Shōji Mayumi , Okamoto Hisashi 
Published: July 2020

AbstractStationary waves of constant shape and constant propagation speed on rotational flows of two layers are computed numerically. Two layers are assumed to be of distinct constant vorticity distributions. Three different kinds of waves of finite depth are considered: pure capillary, capillary-gravity, and gravity waves. The problem is formulated as a bifurcation problem, which involves many parameters and produces a complicated structure of solutions. We adopted a numerical method by which waves with stagnation points can be computed, and obtained variety of new solutions. It is also reported that the locations of the stagnation points vary curiously with the prescribed parameters and that they offer an interesting problem.
HIV transmission by human bite: a case report and review of the literature—implications for post-exposure prophylaxis
Authors: Schürmann Dirk , Hoffmann Christian , Stegemann Miriam S. , Ruwwe-Glösenkamp Christoph , Gürtler Lutz 
Published: July 2020

AbstractWe report a case of a probable HIV-1 transmission by human bite. The analyzed data from ten previously reported suspected or allegedly confirmed HIV transmissions revealed a deep bleeding bite wound as the primary risk factor. A high HIV plasma viral load and bleeding oral lesions are present most of the time during HIV transmission by bite. HIV post-exposure prophylaxis (PEP) should be recommended in case of a bleeding wound resulting from a bite of an HIV-infected person. PEP was missed in this presented case.
On the irreducibility of cones of 3-secant planes
Authors: Ciliberto Ciro 
Published: July 2020

AbstractIn this paper we prove that if $$X\subset {\mathbb P}^r$$

X
⊂

P

r

is a 2-smooth, irreducible, projective non-degenerate variety of dimension n such that $${\text {Sec}}_2(X)={\mathbb P}^r$$

Sec
2

(
X
)

=

P

r

, if $$n > \frac{4}{7}(r-2)$$

n
>

4
7

(
r
-
2
)

and if $$X'$$

X
′

is the projection of X to $${\mathbb P}^{r-1}$$

P

r
-
1

from a general point, then the set of length 3 subschemes of $$X'$$

X
′

which lie on a line form an irreducible variety.
Body Image, Orgasmic Response, and Sexual Relationship Satisfaction: Understanding Relationships and Establishing Typologies Based on Body Image Satisfaction
Authors: Horvath Zsolt , Smith Betina Hodt , Sal Dorottya , Hevesi Krisztina , Rowland David L. 
Published: July 2020

Abstract

Introduction
This study explored the role of body image dissatisfaction on orgasmic response during partnered sex and masturbation and on sexual relationship satisfaction. The study also described typologies of women having different levels of body image satisfaction.

Methods
A sample of 257 Norwegian women responded to an online survey assessing body image dissatisfaction, problems with orgasm, and sexual relationship satisfaction. Using structural equation modeling and factor mixture modeling, the relationship between body image dissatisfaction and orgasmic response was assessed, and clusters of sexual response characteristics associated with varying levels of body image dissatisfaction were identified.

Main Outcome Measure
Orgasmic function during partnered sex and masturbation, along with sexual relationship satisfaction, were assessed as a function of body image.

Results
Body image dissatisfaction, along with a number of covariates, predicted higher levels of “problems with orgasm” during both partnered sex and masturbation, with no significant difference in the association depending on the type of sexual activity. Varying levels of body image dissatisfaction/satisfaction were associated with differences in orgasmic incidence, difficulty, and pleasure during partnered sex; with one orgasmic parameter during masturbation; and with sexual relationship satisfaction.

Conclusion
Body image dissatisfaction and likely concomitant psychological distress are related to impaired orgasmic response during both partnered sex and masturbation and may diminish sexual relationship satisfaction. Women with high body image dissatisfaction can be characterized by specific sexual response patterns.
Chemsex in Italy: Experiences of Men Who Have Sex with Men Consuming Illicit Drugs to Enhance and Prolong Their Sexual Activity
Authors: Nimbi Filippo Maria , Rosati Fausta , Esposito Rita Maria , Stuart David , Simonelli Chiara , Tambelli Renata 
Published: July 2020

Abstract

Background
Chemsex is a novel phenomenon referring to the consumption of illicit drugs to facilitate, enhance, and prolong the sexual experience in men who have sex with men (MSM).

Aim
The present study aims to investigate contexts, patterns of substance use, first chemsex experience, and harm reduction in a group of MSM practicing chemsex in Italy.

Methods
Thirty MSM involved in chemsex activities were interviewed between February and July 2019.

Outcomes
The interviews were conducted using an ad hoc grid exploring general characteristics of Italian chemsex, patterns of substance use, first chemsex experience, and harm reduction opinions.

Results
Chemsex in Italy showed important peculiarities and patterns because of sociocultural background. Chemsex was mainly reported in private venues within couple and group sexual activities. Most participants attended chemsex sessions about 1-2 times per month often concurring with men-only club events. Freebase cocaine emerged among the most relevant substances consumed together with gamma-hydroxybutyrate/gamma-butyrolactone, crystal methamphetamine, and mephedrone. A rare use of injected substances compared with other European Union countries was shown. Given the high prevalence of erectile problems, a large use of phosphodiesterase type 5 inhibitors was reported, and noncoital sexual activities were usually preferred (eg, oral sex, fist fucking). The first chemsex experiences were usually accessed by geolocation-based dating apps and sexual partners and were generally described as positive experiences, with some negative consequences at the end of the session (dysphoric mental states, guilt, craving). Taking part in international gay events seems to favor the first experience of chemsex for some participants. Moreover, some MSM practiced chemsex only abroad or in other cities in Italy so as not to be recognized as chem users in their daily environment.

Clinical Translation
Implications for ad hoc harm reduction programs are discussed.

Strengths & Limitations
Despite the methodological limitations due to participants’ number and the absence of interviews audio recording, results highlighted some relevant characteristics of chemsex in Italy, such as freebase cocaine use, attitudes regarding slamming, geographical movements, and secrecy.

Conclusion
The results revealed a need for greater scientific and public attention on chemsex to act with the most specific and effective prevention and harm reduction tools.
Phase-controlled field-effect micromixing using AC electroosmosis
Authors: Modarres Paresa , Tabrizian Maryam 
Published: July 2020

AbstractThe exploration and application of electrokinetic techniques in micro total analysis systems have become ubiquitous in recent years, and scientists are expanding the use of such techniques in areas where comparable active or passive methods are not as successful. In this work, for the first time, we utilize the concept of AC electroosmosis to design a phase-controlled field-effect micromixer that benefits from a three-finger sinusoidally shaped electrodes. Analogous to field-effect transistor devices, the principle of operation for the proposed micromixer is governed by the source-gate and source-drain voltage potentials that are modulated by introducing a phase lag between the driving electrodes. At an optimized flow rate and biasing scheme, we demonstrate that the source, gate, and drain voltage phase relations can be configured such that the micromixer switches from an unmixed state (phase shift of 0°) to a mixed state (phase shift of 180°). High mixing efficiencies beyond 90% was achieved at a volumetric flow rate of 4 µL/min corresponding to ~13.9 mm/s at optimized voltage excitation conditions. Finally, we employed the proposed micromixer for the synthesis of nanoscale lipid-based drug delivery vesicles through the process of electrohydrodynamic-mediated nanoprecipitation. The phase-controlled electrohydrodynamic mixing utilized for the nanoprecipitation technique proved that nanoparticles of improved monodispersity and concentration can be produced when mixing efficiency is enhanced by tuning the phase shifts between electrodes.