bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Residual Stenosis of the Coronary Arteries in the Dynamics Systolicdiastolic Left Ventricular Function after Acute Coronary Syndrome
Authors: Shveс D. A. , Povetkin S. V. 
Published: April 2020

Objective. The aim of the research under consideration was to study the dynamics of a local systolic-diastolic function of patients with various ischemic heart disease (IHD) progressions after survival of an acute coronary syndrome (ACS) provided there are residual stenoses of coronary arteries.Materials and Methods. There were 112 patients suffering from ACS who took part in the research. The diagnosis was verified (acute myocardial infarction or unstable angina) in accordance with the recommendations of European Society of Cardiology (ESC). All patients were divided into two groups depending on the occurrence of major acute cardiac events (MACE): 59 patients with aggravated IHD progression and 152 patients with non-aggravated course. Echo-cardiography was performed on a scanner Philips iE33 (the Netherlands) with a consideration to systolic and diastolic functions parameters of a left ventricle. Quantitative analysis of the left ventricle was executed in the mode of Tissue Doppler Imaging (TDI) and according to the method of tracing the patches of the ultra-sound image gray scale (ST).Results. In the course of the aggravated IHD a decrease in systolic-diastolic function of left ventricle has been discovered. It has been found out that the amount of the systolic peak of longitudinal strain of the left ventricle anteroseptal wall less than 12% is associated with a greater extent of coronary atherosclerosis and aggravated progression of IHD. TDI and ST methods have enabled to reveal that in the course of non-aggravated IHD the contractility and the diastolic function of the left ventricle anteroseptal wall improve in combination with the increase in the contractility of the left ventricle inferolateral wall. During an aggravated IHD progression the contractility and diastolic function of the left ventricle anteresoptal wall decreases without an increase in contractility and diastolic function of the inferior and inferolateral walls of the left ventricle. The reason for such results might be a progressing myocardial ischemia of the left ventricle anteroseptal wall despite the sufficient anterior interventricular artery stenting. The presence of the relevant residual stenoses of the circumflex and right coronary arteries increases the possibility of the aggravated IHD progressing especially by the end of the fourth year of observation.Conclusion. The disbalance of the local contractility of anterior, inferior and inferolateral left ventricle walls in the course of aggravated IHD is connected with the CA residual stenoses presence and forwards the decrease in global systolic-diastolic function of the left ventricle. The final results can serve as a foundation for optimization of recommendations for performing PCI on the patients with multivessel disease of CA.
Evaluation of swede score and reid score to improve the predictive value of colposcopy and its correlation with histology
Authors: Karya Urmila , Zehra Azme , Rani Anupam 
Published: April 2020

Background: Cervical carcinoma is the second most common malignancy amongst women in India. It is regarded as a public health problem and a priority in cancer control programmes by the WHO. Colposcopy has proven to be very useful in identifying and guiding the biopsy of dysplastic lesion. To minimize inter-observer variation, colposcopic scoring system has been introduced.Methods: A prospective cross- sectional study including 250 women in whom the prevalence of different grades CIN was done. Co-relation of Pap (cytology) with colposcopy scoring system viz. Reid’s and Swede scores, has been made in this study. The two screening methods were compared and their statistical association with histological findings were analyzed.Results: Per speculum examination performed in 250 sexually active women with suspicious looking cervix, belonging to 25-60 years of age, with most common presenting complaints of pain abdomen (38.8%) followed by leucorrhoea, irregular cycles and Post coital bleed. Unhealthy cervix (49.2%) and persistent discharge (28%) were the most common indications for colposcopy. An assessment of both SWEDE score and Reid score as a function of histological findings was done, while Swede score of >5 showed slightly more sensitivity (100%) for diagnosing CIN1+ lesions, Reids score of >5 was more specific (100%) with a higher positive predictive value (100%) for diagnosing CIN 1, 2, 3 and invasive cervical carcinoma. There was a marked positive association between Reid score and SWEDE score.Conclusions: The colposcopic scoring systems and histopathology showed significant compliance. Predictive accuracy of colposcopy increased with increasing severity of disease.
Study of demography and clinical profile of ectopic pregnancies in a tertiary level hospital in Uttarakhand: a five year review
Authors: Nimonkar Shweta , Chaudhari Priyanka , Saxena Namrata , Gupta Vineeta , Tandon Archna , Singh Parul 
Published: April 2020

Background: Ectopic pregnancy is a condition when a fertilized ovum is implanted outside the uterine cavity. Life threatening risk of rupture of ectopic pregnancy remains one of the important causes of maternal mortality in India. The aim of study is to analyse the clinical profile, associated risk factors, complications, treatment outcomes to improve maternal mortality and morbidity associated with ectopic pregnancy.Methods: It is a retrospective study conducted at Shri Guru Ram Rai Institute of Medical and Health Sciences from January 2015 to January 2020. A total of 182 patients diagnosed of Ectopic Pregnancy were analysed for clinical profile, risk factors, serology, ultrasound findings, complications, treatment offered and outcome.Results: During the study period of 5 years there were total 182 patients who were diagnosed of ectopic pregnancy showing the incidence of ectopic pregnancy in our hospital 1.4% of total number of deliveries. Majority of patients were in the age group of 25 to 30 years (43.95%). Mostly multiparous women (80.1%) had ectopic pregnancy. Majority of patients (56.1%) had no associated risk factors for ectopic pregnancy. Main presenting complain was abdominal pain in 58.8% of patients. Majority of patients (63.2%) had surgery as primary care which indicates delay in diagnosis and arrival at hospital especially in hilly region of Uttarakhand.Conclusions: Ectopic pregnancies need to be diagnosed timely to decrease maternal morbidities and mortalities. Clinical signs and symptoms with serology (Serum beta hCG) and radiological findings helps to optimize treatment for potentially life-threatening condition.
ПРИНЦИПЫ УСТОЙЧИВОГО РАЗВИТИЯ ГОРНОТЕХНИЧЕСКИХ СИСТЕМ В ПЕРЕХОДНЫЕ ПЕРИОДЫ
Authors: Бурмистров Константин Владимирович , Осинцев Никита Анатольевич 
Published: April 2020

Актуальность исследования. Функционирование горнодобывающих предприятий в современных условиях характеризуется активным воздействием факторов внешней и внутренней среды. В условиях нестабильной внешней среды, при переходе от одного этапа разработки к другому, подсистемы горнодобывающих предприятий должны подчиняться цели обеспечения устойчивого функционирования предприятия – обеспечению выходных потоков с заданными параметрами. В этот период изменяется устойчивость горнотехнической системы, что оказывает влияние на состояние экономической и социальной подсистем горнодобывающих предприятий, а также на состояние окружающей среды, вызванное изменениями в параметрах технологии и технологических процессах. Это требует разработки новых подходов и принципов управления работой горнодобывающих предприятий, основанных на согласовании экономических целей с целями в области экологии и социального развития. Цель: разработка концепции устойчивого развития горнотехнических систем в переходные периоды разработки месторождений на основе систематизации существующих принципов устойчивого развития в горнодобывающей отрасли. Объекты: горнодобывающее предприятие, горнотехническая система, система вскрытия карьера. Методы: обзор научной литературы, структурно функциональный анализ, системный анализ. Результаты. Обоснована ключевая роль системы вскрытия в структуре горнотехнической системы для обеспечения целей устойчивого развития горнодобывающих предприятий. Выполнена систематизация принципов устойчивого функционирования и развития горнодобывающих предприятий и его систем с выделением четырех групп принципов: общесистемные принципы управления, принципы развития горнодобывающих предприятий, принципы развития горнотехнической системы, принципы развития подсистем горнотехнической системы. В основу предлагаемой системы принципов положена идея последовательного преобразования подсистем горнотехнической системы на всех этапах проектирования и эксплуатации, учитывающая экономические, социальные и экологические аспекты с целью обеспечения заданных параметров функционирования горнодобывающих предприятий. Предложена концепция устойчивого развития горнотехнической системы в переходные периоды разработки. Использование предлагаемого подхода в период перехода от открытых горных работ к открыто-подземному способу разработки позволяет улучшить экономические, экологические и социальные показатели функционирования систем горнодобывающих предприятий.
Program Kemitraan Universitas bagi Pengurus Kelompok Tani Sumber Rejeki III untuk Mengelola Administrasi Keuangan Syariah
Authors: Widyanto R Arri , Sunarni Sunarni , Triyanto Andi 
Published: April 2020

Sumber Rejeki III Farmers Group is an organization that accommodates farmers in Turen, Kradenan Village. Currently there are 45 active members of farmer groups, all of whom are from Turen. The management of the average main job is farmers who are on average 48 years old. The level of education of the management of high school and equivalent farmer groups. The level of mastery of computer operations 0% of all managers. The problem that occurs in this farmer group is that there are no administrators who can operate the computer, so the administration has not been well organized. All documents are written manually using separate books and note papers. Especially in making reports of Lembaga Keuangan Mikro(LKM) that must be reported every month to farmer groups, they must collect from many records and not infrequently there are records that are scattered or lost which cause reports especially financial statements to be invalid. The objectives of this partnership program are: (a) Giving skills to operate computers, especially office application programs for farmer group administrators. (b) Giving skills in making invitations automatically using a mail merge facility. (c). Improve ability in recording and making financial reports. The methods used: (a) the preparation stage, (b) the implementation stage, (c) the evaluation phase and (d) preparing the report. The results of this activity, the average level of mastery of computer utilization for administrative activities are as follows: Mastering (0.78%) and Self-mastering (0.22%), Output of PKU is increasing the ability of partners to use computer applications for administration to 70% of the original target of 50%. In addition, savings and loan activities for these farmer groups' LKM use the sharia accounting system
Integrated analysis of miRNA and mRNA expression profiles in testes of Duroc and Meishan boars
Authors: Ding Haisheng , Liu Min , zhou Changfan , You Xiangbin , Su Tao , Yang Youbing , Xu Dequan 
Published: April 2020

Abstract
Background: MicroRNAs (miRNAs) are small non-coding RNAs playing vital roles in regulating posttranscriptional gene expression. Elucidating the expression regulation of miRNAs underlying pig testis development will contribute to a better understanding of boar fertility and spermatogenesis. Results: In this study, miRNA expression profile was investigated in testes of Duroc and Meishan boars at 20, 75, and 270 days of age by high-throughput sequencing. Forty-five differentially expressed miRNAs were identified from testes of Duroc and Meishan boars before and after puberty. Integrated analysis of miRNA and mRNA profiles predicted many miRNA-mRNA pairs. Gene ontology and biological pathway analyses revealed that predicted target genes of ssc-mir-423-5p, ssc-mir-34c, ssc-mir-107, ssc-165 mir-196b-5p, ssc-mir-92a, ssc-mir-320, ssc-mir-10a-5p, and ssc-mir-181b were involved in sexual reproduction, male gamete generation, and spermatogenesis, and GnRH, Wnt, and MAPK signaling pathway. Four significantly differentially expressed miRNAs and their predicted target genes were validated by quantitative real-time polymerase chain reaction, and phospholipase C beta 1 (PLCβ1) gene was verified to be a target of ssc-mir-423-5p. Conclusions: This study provides an insight into the functional roles of miRNAs in testis development and spermatogenesis and offers useful resources for understanding differences in sexual function development caused by the change in miRNAs expression between Duroc and Meishan boars.
The effect of nicotinamide adenine dinucleotide phosphate oxidase 4 on migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis
Authors: Lee Ha-Reum , Yoo Su-Jin , Kim Jinhyun , Yoo In Seol , Park Chan Keol , Kang Seong Wook 
Published: April 2020

Abstract
Background: Reactive oxygen species (ROS) regulate the migration and invasion of fibroblast-like synoviocytes (FLS), which are key effector cells in rheumatoid arthritis (RA) pathogenesis. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) induces ROS generation and consequently, enhances cell migration. Despite the important interrelationship between RA, FLS, and ROS, the effect of NOX4 on RA pathogenesis remains unclear.Methods: FLS isolated from RA (n=5) and osteoarthritis (OA, n=5) patients were stimulated with recombinant interleukin 17 (IL-17; 10 ng/ml) and tumor necrosis factor alpha (TNF-α; 10 ng/ml) for 1 h. Cell migration, invasion, adhesion molecule expression, vascular endothelial growth factor (VEGF) secretion, and ROS expression were examined. The mRNA and protein levels of NOX4 were analyzed by RT-qPCR and western blotting, respectively. The NOX4 inhibitor GLX351322 and NOX4 siRNA were used to inhibit NOX4 to probe the effect of NOX4 on these cellular processes.Results: Migration of RA FLS was increased 2.48-fold after stimulation with IL-17 and TNF-α, while no difference was observed for OA FLS. ROS expression increased in parallel with invasiveness of FLS following cytokine stimulation. When the expression of NOX was examined, NOX4 was significantly increased by 9.73-fold in RA FLS compared to unstimulated FLS. Following NOX4 inhibition, cytokine-induced vascular cell adhesion molecule 1 (VCAM1), VEGF, and migration and invasion capacity of RA FLS were markedly decreased to unstimulated levels.Conclusion: NOX4 is a key contributor to cytokine-enhanced migration and invasion via modulation of ROS, VCAM1, and VEGF in RA FLS.
Identification of Potential Crucial Genes in Atrial Fibrillation: A Bioinformatic Analysis
Authors: Zhang Junguo , Huang Xin , Wang Xiaojie , Gao Yanhui , Liu Li , Li Ziyi , Chen Xuejiao , Zeng Jie , Ye Zebing , Li Guowei 
Published: April 2020

Abstract
Background Atrial fibrillation (AF) is at least partially heritable, affecting 2-3% of the population in Europe and the USA. However, a substantial proportion of heritability is still lacking. In the present study, we aim to identify potential crucial genes associated with AF through bioinformatic analyses of public datasets. Methods Microarray data sets of GSE115574, GSE31821, GSE79768, GSE41177 and GSE14975 from the Gene Expression Omnibus (GEO) database were retrieved. After merging all microarray data and adjusting batch effect, differentially expressed genes (DEGs) were identified. Functional enrichment analyses based on Gene Ontology (GO) resource, Kyoto Encyclopedia of Genes and Genomes (KEGG) resource, Gene Set Enrichment Analysis (GSEA), Reactome Pathway Database and Disease Ontology (DO) were carried out. Protein-protein interaction (PPI) network was constructed using the STRING database. Combined with aforementioned significant bioinformatics information, potential crucial genes were subsequently selected. The comparative toxicogenomics database (CTD) was carried out to explore the interaction between potential crucial genes and AF. Result We identified 27 of DEGs with gene expression fold change (FC) ≥ 1.5 and 5 with FC ≥ 2 of AF patients compared with sinus rhythm controls. The most significantly enriched pathway was regulation of insulin-like growth factor transport and uptake by insulin-like growth factor binding proteins. IGFBP2, C1orf105, FHL2, CHGB, ATP1B4, IGFBP3, SLC26A9, CXCR4 and HTR2B were considered the potential crucial genes. CTD showed CXCR4, IGFBP2, IGFBP3 and FHL2 had higher scores with AF. Conclusions The 9 potential crucial genes, especially CXCR4, IGFBP2, IGFBP3 and FHL2 , may be associated with risk of AF. Our study provided new insights of AF into genetics, molecular pathogenesis and new therapeutic targets.
CT differential diagnosis of COVID-19 and non-COVID-19 in symptomatic suspects: a practical scoring method
Authors: Luo Lin , Luo Zhendong , Jia Yizhen , Zhou Cuiping , He Jianlong , Lyu Jianxun , Shen Xinping 
Published: April 2020

Abstract
Background: Although typical and atypical CT image findings of COVID-19 are reported in current studies, the CT image features of COVID-19 overlap with those of viral pneumonia and other respiratory diseases. Hence, it is difficult to make an exclusive diagnosis.Methods : Thirty confirmed cases of COVID-19 and forty-three cases of other aetiology or clinically confirmed non-COVID-19 in a general hospital were included. The clinical data including age, sex, exposure history, laboratory parameters and aetiological diagnosis of all patients were collected. Seven positive signs (posterior part/lower lobe predilection, bilateral involvement, rounded GGO, subpleural bandlike GGO, crazy-paving pattern, peripheral distribution, and GGO +/- consolidation) from significant COVID-19 CT image features and four negative signs (only one lobe involvement, only central distribution, tree-in-bud sign, and bronchial wall thickening) from other non-COVID-19 pneumonia were used. The scoring analysis of CT features was compared between the two groups (COVID-19 and non-COVID-19).Results : Older age, symptoms of diarrhoea, exposure history related to Wuhan, and a lower white blood cell and lymphocyte count were significantly suggestive of COVID-19 rather than non-COVID-19 (p<0.05). The receiver operating characteristic (ROC) curve of the combined CT image features analysis revealed that the area under the curve (AUC) of the scoring system was 0.854. These cut-off values yielded a sensitivity of 56.67% and a specificity of 95.35% for a score>4, a sensitivity of 100% and a specificity of 23.26% for a score>0, and a sensitivity of 86.67% and a specificity of 67.44% for a score>2.Conclusions : With a simple and practical scoring system based on CT imaging features, we can make a hierarchical diagnosis of COVID-19 and non-COVID-19 with different management suggestions.
Modification of Magerl’s technique for the placement of translaminar facet screws in transforaminal lumbar interbody fusion: a technical note and comparative outcome analysis
Authors: Xu Daoliang , Jin Haimin , Chen Jiaoxiang , Wang Xiangyang 
Published: April 2020

Abstract
Background

To describe and illustrate a safe and effective technique for the placement of translaminar facet screws (TLFS) in transforaminal lumbar interbody fusion (TLIF).
Methods

Forty-two patients with single-level lumbar diseases were divided into two groups randomly. 21 patients were treated by traditional TLIF using bilateral pedicle screws fixation (BPS) while the other patients underwent insertion of a unilateral pedicle screw (UPS)and contralateral TLFS using our modified technique. In this technique, a small unicortical “hole” was formed adjacent to the contralateral facet joint to ensure that insertion of the screw could be directly visualized through the hole to prevent violation of the spinal canal. The ODI, JOA, VAPS questionnaire, the mean operation time, mean operative blood loss, length of stay and postoperative complications were collected for analysis.
Results

There is no significant difference between the BPS and UPS + TLFS group in the preoperative and postoperative ODI, JOA or VAPS at each follow- up visit, while the UPS + TLFS group using our modified technique significantly reduced the mean operation time, the mean estimated blood loss and the length of stay. These results demonstrated this modified technique to be safe and effective in TLIF.
Conclusions

In contrast to conventional TLIF, our modified technique for placing TLFS in TLIF can reduce soft tissue injuries, reduce the operation risk of violation of the spinal canal and the expenses, minimize radiation exposure, and shorten the length of the operation without a concurrent reduction in clinical efficacy.
Needs, aggravation, and degree of burnout in informal care providers of patients with chronic CVD
Authors: Szlenk-Czyczerska Elżbieta , Guzik Marika , Bielska Dorota Emilia , Ławnik Anna , Polański Piotr , Kurpas Donata 
Published: April 2020

Abstract
Background.

The growing number of patients with chronic cardiovascular disease (CVD) has created an increased demand for homecare. Therefore, it is necessary to analyze the burden of homecare on caregivers, and gain insight into their biopsychosocial situations. By identifying groups of caregivers that experience significant levels of stress and burnout, guardian education (i.e. specialized and supportive training) and practical support can be specifically directed towards these groups. This study aimed to answer two main questions with respect to home carers for people with CVD: 1) Are the needs of home carers being met (and at what level), and what is the severity of burnout of home carers? and 2) What sociodemographic variables of home carers are related to unmet needs and severity of burnout?
Methods.

This study reports on 161 informal home care providers of patients with CVDs. The research was conducted in the homes of patients, using the Camberwell Assessment of Need Short Appraisal Schedule (CANSAS), the Maslach Burnout Inventory (MBI), and a structured interview questionnaire developed by the authors. Spearman’s rank correlation coefficient test and logistic regression were used for analyses.
Results.

The majority of the participants were female (70.2%; n = 113). We found that younger care providers were less likely to report unmet needs (p = 0.011), and less likely to report burnout as measured by the MBI Emotional Exhaustion (p = 0.010) and Depersonalization (p = 0.009) subscales. Care providers with primary education were more likely to report burnout on the MBI Depersonalization subscale (p = 0.028). In addition, care providers who worked more often reported higher levels of met needs (p = 0.022), and burnout as measured on the MBI Depersonalization (p = 0.005) and Emotional Exhaustion (p = 0.018) subscales. Subjects residing in urban areas were more likely to report unmet needs (p = 0.007), and were also more likely to report burnout as measured on the MBI Emotional Exhaustion (p = 0.006) subscale.
Conclusion.

Older care providers who are unemployed and reside in cities and unemployed should be targeted with directed programmes to determine the category of unmet needs, and for personalized support. Care providers with these demographic characteristics should be targeted for occupational burnout prevention programmes.