bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drivers of taxonomic, functional and phylogenetic diversities in dominant ground-dwelling arthropods of coastal heathlands
Authors: Hacala Axel , Lafage Denis , Prinzing Andreas , Sawtschuk Jérôme , Pétillon Julien 
Published: January 2021

AbstractAlthough functional and phylogenetic diversities are increasingly used in ecology for a large variety of purposes, their relationships remain unclear and likely vary presumably over taxa, yet most recent studies focused on plant communities. Different concepts predict that a community becomes functionally more diverse by adding phylogenetic lineages, subtracting lineages, adding species, reducing or increasing environmental constraints. In this study, we investigated ground-dwelling spider, ground beetle and ant assemblages in coastal heathlands (>11 000 individuals, 216 species), and their estimated functional and phylogenetic diversities as minimum spanning trees using several traits related to the morphology, feeding habits and dispersal of species, and phylogenetic trees, respectively. Correlations were overall positive and high between functional and phylogenetic diversities. Accounting for taxonomic diversities and environments made disappear this relationship in ants, but maintained them in spiders and ground beetles, where taxonomic diversity related to functional diversity only via increasing phylogenetic diversity. Environmental constraints reduced functional diversity in ants, but affected functional diversity only indirectly via phylogenetic diversity (ground beetles) and taxonomic and then phylogenetic diversity (spiders and ground beetles). Results are consistent with phylogenetic conservatism in traits in spiders and ground beetles, while in ants traits appear more neutral with any new species potentially representing a new trait state. Lineage diversities mostly increased with taxonomic diversities, possibly reflecting un-measured environmental conditions.
Metabolic engineering ofSaccharomyces cerevisiaefor efficient conversions of glycerol to ethanol
Authors: Khattab Sadat M. R. , Watanabe Takashi 
Published: January 2021

Glycerol is an eco-friendly solvent enhancing plant-biomass decomposition through the glycell process to bio-based chemicals. Nonetheless, the lack of efficient conversion of glycerol by naturalSaccharomyces cerevisiaerestrains many biorefineries-scenarios. Here, we outline a comprehensive strategy for generating efficient glycerol fermentingS. cerevisiaevia rewriting the oxidation of cytosolic nicotinamide adenine dinucleotide by O2-dependent dynamic shuttle while abolishing glycerol phosphorylation and biosynthesis pathways. By following a vigorous glycerol oxidative pathway, our engineered strain demonstrated a breakthrough in conversion efficiency (CE), reaching up to 0.49g-ethanol/g-glycerol—98% of theoretical conversion—with production rate >1 gL−1h−1on rich-medium. Interestingly, the glycerol consumption and its fermentation unrepressed during the mixing by glucose until the strain produced >86 g/L of bioethanol with 92.8% of CE. Moreover, fine-tuning of O2boosted the production rate to >2 gL−1h−1with 82% of CE. Impressively, the strategy flipped the ancestral yeast even from non-growing on glycerol, on the minimal medium, to a fermenting strain with productivities 0.25-0.5 gL−1h−1and 84-78% of CE, respectively. Our findings promote utlising glycerol efficiently in several eco-friendly biorefinery approaches.SummaryEfficient fermentation of glycerol in S. cerevisiae was established by comprehensive engineering of glycerol pathways and rewriting NADH pathway.
Bromodomain 4 inhibition leads toMYCNdownregulation in Wilms’ tumor cells
Authors: Woods Andrew D. , Berlow Noah E. , Purohit Reshma , Freier Katherine E. Tranbarger , Michalek Joel E. , Lathara Melvin , Matlock Kevin , Srivivasa Ganapati , Royer-Pokora Brigitte , Veselska Renata , Keller Charles 
Published: January 2021

AbstractWilms’ tumor is the most common childhood kidney cancer. Two distinct histological subtypes of Wilms’ tumor have been described: tumors lacking anaplasia (the favorable subtype) and tumors displaying anaplastic features (the unfavorable subtype). Children with favorable disease generally have a very good prognosis, while those with anaplasia are oftentimes refractory to standard treatments and suffer poor outcomes.MYCNdysregulation has been associated with a number of pediatric cancers including the anaplastic subtype of Wilms’ tumor. In this context, we undertook a functional genomics approach to uncover novel therapeutic strategies for those patients with anaplastic Wilms’ tumor. Genomic analysis andin vitroexperimentation demonstrate that Wilms’ tumor cell growth can be reduced by modulatingMYCNoverexpression via BRD4 inhibition. We observed a time dependent reduction of MYCN and MYC protein levels upon BRD4 inhibition in Wilms’ tumor cell lines which led to increased cell death and suppressed proliferation. We suggest that AZD5153, a novel dual-BRD4 inhibitor, can reduce MYCN levels and should be further explored for its therapeutic potential against Wilms’ tumor.
Inhibition of Extracellular Vesicle-Associated MMP2 Abrogates Intercellular Transfer of Hepatic miR-122 to Tissue Macrophages and Curtails Liver Inflammation
Authors: Das Arnab , Basu Sudarshana , Bandyopadhyay Diptankar , Dutta Debduti , Chakrabarti Sreemoyee , Adak Moumita , Swarnakar Snehasikta , Chakrabarti Partha , Bhattacharyya Suvendra N. 
Published: January 2021

AbstractmicroRNA-122 (miR-122), a liver specific regulatory RNA, plays an important role in controlling metabolic homeostasis in mammalian liver cells. Interestingly, miR-122 is also a proinflammatory microRNA and when exported to tissue resident macrophage induces expression of inflammatory cytokines there. We found intercellular transfer of miR-122 in lipid exposed liver plays a role in liver inflammation. Exploring the mechanism of intercellular miR-122 transfer from hepatic cells, we detected MMP2 on the membrane of extracellular vesicles derived from hepatic cells which proved to be essential for transfer of extracellular vesicles and their miRNA content from hepatic to non-hepatic cells. Matrix metalloprotease 2 or MMP2 is a metalloproteinase that plays a key role in shaping and remodelling the extracellular matrix of human tissue by targeting degradation of matrix proteins. MMP2 was found to increase the movement of the EVs along the extracellular matrix to enhance their uptake in recipient cells. Inhibition of MMP2 restricts functional transfer of hepatic miRNAs across the hepatic and non-hepatic cell boundaries. By targeting MMP2, we could reduce the innate immune response in mammalian liver by preventing intra-tissue miR-122 transfer.Abstract FigureHuman hepatocytes on exposure to high lipid export out miRNAs including proinflammatory miR-122.Extracellular miR-122 is taken up by tissue macrophages to get them activated to produce inflammatory cytokines.MMP2 present on the surface of the EVs released by hepatocyte is essential for miRNA transfer to macrophage cellsInhibition of MMP2 prevents miR-122 transfer to macrophage and stops activation of recipient macrophage.
Experimental investigation on nozzle diameter of vortex gripper
Authors: Zhao Jianghong , Li Xin 
Published: January 2021

Purpose
Vortex grippers use tangential nozzles to form vortex flow and are able to grip a workpiece without any physical contact, thus avoiding any unintentional workpiece damage. This study aims to use experimental and theoretical methods to investigate the effects of nozzle diameter on the performance.

Design/methodology/approach
First, various suction force-distance curves were developed to analyze the effects of nozzle diameter on the maximum suction force. This study determines the tangential velocity distribution on the workpiece surface by substituting the experimental pressure distribution data into simplified Navier-Stokes equations and then used these equations to analyze the effects on the flow field. Subsequent theoretical analysis of the distribution of pressure and circumferential velocity further validated the experimental results. Next, by rearranging these relationships, the study considered the effects of nozzle diameter on the inherent vortex gripper characteristics. In addition, this study developed various suction force-energy consumption curves to analyze the effects of nozzle diameter.

Findings
The results of this study indicated that the vortex gripper’s circumferential velocity and maximum suction force decrease with increasing nozzle diameter. Nozzle diameter did not significantly affect the inherent frequency of the vortex gripper-workpiece inertial system or the corresponding suspension stability of the workpiece. However, an increase in nozzle diameter did effectively increase the vortex gripper’s suspension region. Finally, as the nozzle diameter increased, the energy required to achieve the same maximum suction force decreased.

Originality/value
This study’s findings can enable optimization of nozzle design in emerging vortex gripper designs and facilitate informed selection among existing vortex grippers.
Business analytics practices and managerial implications based on the evidence from Korea
Authors: Min Hokey 
Published: January 2021

PurposeDespite a growing interest in business analytics (BA) from the business and academic communities, it is still unknown what truly motivates and hinders the adoption of BA. To have a clear picture of what will lead to the successful implementation of BA, this paper identifies contextual variables (e.g. user characteristics, organizational readiness and technology infrastructure/expertise) that significantly influence the BA adoption decision.Design/methodology/approachThis paper conducted a series of classification, discriminant and logistics regressions analyses to analyze the differences in mail survey responses between adopters and nonadopters of BA and then determine what either motivate or inhibit the BA adoption.FindingsThrough a series of hypothesis testing, we discovered that large firms with a greater number of information technology (IT) staff and budget tended to adopt BA more than their smaller counterparts. Also, we found that BA skeptics, who did not fully recognize BA benefit potentials, were more concerned about BA implementation costs and experienced the greater organization resistance to BA adoption than the others did. Therefore, they were less likely to adopt BA.Originality/valueIn the era of knowledge-based economy, the firm's ability to derive actionable insights from big data can be a game changer. Such ability can be developed and nurtured by utilizing BA which is designed to help business executives and policymakers make well-thought and informed decisions. This paper is one of the first attempts to develop practical guidelines for the successful implementation of BA based on the exploratory study of BA practices among the Korean firms.
Putting family first as a boundary management tactic
Authors: Thompson Merideth , Carlson Dawn S. , Kacmar K. Michele 
Published: January 2021

PurposeThe authors examine a boundary management tactic for managing the work–family interface: putting family first (PFF). PFF is a boundary management tactic defined as the voluntary behavior of intentionally putting family obligations ahead of work obligations in a way that violates organizational normsDesign/methodology/approachIn Study 1, The authors develop a theoretically derived measure of PFF and distinguish it theoretically and empirically from similar existing constructs, examining convergent and discriminate validity to demonstrate its uniqueness. In Study 2, the authors demonstrate PFF's predictive validity beyond the job incumbent using a three-way matched sample of 226 individuals, including the job incumbent's coworker and spouse.FindingsThe authors established and validated a measure of PFF, developing and replicating the nomological network. PFF crossed over to positively relate to coworker role overload, job frustration and work–family conflict and to spousal stress transmission and relationship tension. Similarly, PFF related negatively to spousal family satisfaction and organizational commitment.Originality/valueThe authors extend the work–family and boundary management literatures by proposing a new form of boundary management, PFF, which is a tactic for managing the work–family interface, and explore how its use influences not only the job incumbent but also the coworker and the spouse.
Machiavellianism, locus of control, moral identity, and ethical leadership among public service leaders in Malaysia: the moderating effect of ethical role modelling
Authors: Zainun Nor Farah Hanis , Johari Johanim , Adnan Zurina 
Published: January 2021

PurposeThe objective of this study is to examine the predicting role of Machiavellianism, locus of control and moral identity on ethical leadership. This study also assessed the moderating role of ethical role modelling in the linkage between Machiavellianism, locus of control, moral identity and ethical leadership.Design/methodology/approachA total of 202 public service leaders in Malaysia participated in the study. A quantitative study was conducted and structural equation modelling was used to test the hypotheses.FindingsMoral identity poses a substantial influence on ethical leadership. Ethical role modelling is a significant moderator in the association between moral identity and ethical leadership.Research limitations/implicationsThis study contributes to the social learning theory by assessing Machiavellianism, locus of control and moral identity as the predictors of ethical leadership among public service leaders in Malaysia. Future study can be further extended to both managerial and support staff to understand the ethical phenomenon in Malaysian public sector.Practical implicationsThe study highlights the need for public sector to give considerable attention to moral identity in boosting ethical leadership among public service leaders in Malaysia's public sector. Furthermore, the element of ethical role modelling should not be neglected as this factor is a valid moderator in nurturing ethical leadership among public service leaders.Originality/valueThe study deepens the knowledge on the importance of ethical role modelling as a moderator in assessing the influence of the predictors on ethical leadership. Further, this study demonstrates that public service leaders who reported high moral identity would have higher ethical leadership if they experienced good ethical role modelling.
Effect of changing geometrical characteristics for different shapes of a single ridge passing through elastohydrodynamic of point contacts
Authors: Abd Alsamieh Mohamed 
Published: January 2021

Purpose
The purpose of this paper is to study the behavior of a single ridge passing through elastohydrodynamic lubrication of point contacts problem for different ridge shapes and sizes, including flat-top, triangular and cosine wave pattern to get an optimal ridge profile.

Design/methodology/approach
The time-dependent Reynolds’ equation is solved using Newton–Raphson technique. Several shapes of surface feature are simulated and the film thickness and pressure distribution are obtained at every time step by simultaneous solution of the Reynolds’ equation and film thickness equation, including elastic deformation. Film thickness and pressure distribution are chosen to be the criteria in the comparisons.

Findings
The geometrical characteristics of the ridge play an important role in the formation of lubricant film thickness profile and the pressure distribution through the contact zone. To minimize wear, friction and fatigue life, an optimal ridge profile should have smooth shape with small ridge size. Obtained results are compared with other published numerical results and show a good agreement.

Originality/value
The study evaluates the performance of different surface features of a single ridge with different shapes and sizes passing through elastohydrodynamic of point contact problem in relation to film thickness and pressure profile.
An improved degraded adhesion model for wheel–rail under braking conditions
Authors: Zhu Wenliang , Zhu Wenjian , Zheng Shubin , Wu Na 
Published: January 2021

Purpose
The purpose of this paper is to develop an improved adhesion model to better reproduce the low adhesion condition of the anti-skid control for rail vehicles under braking condition.

Design/methodology/approach
In view of the low adhesion characteristics for rail vehicles under braking conditions, the Polach adhesion model was improved based on the sliding power and sliding energy. The wheel–rail low adhesion model suitable for braking condition was given. The analysis of braking anti-skid control under emergency braking condition was carried out through the co-simulation, and compared with the test data; the effectiveness and practicability of the improved low adhesion model were verified.

Findings
The results showed that the improved adhesion model is simple and efficient and the parameters involved are less, and it can be directly applied to the real-time simulation of anti-skid control in the process of train braking.

Originality/value
This paper can provide a theoretical reference for the reasons of change and improvement of adhesion between wheel and rail caused by the adjustment of braking force under anti-skid control, which can fulfill a need to the study of sliding energy on the contact surface, the removal effect of pollutants on the wheel–rail surface and the improvement and recovery of adhesion caused.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-07-2020-0244/
The role of intrinsic and extrinsic motivations in sharing economy post-adoption
Authors: Oliveira Tiago , Barbeitos Iolanda , Calado Antonela 
Published: January 2021

PurposeThe purpose of this paper is to examine use and sharing economy (SE) continuance intention, and the mediation effects of use between individuals' motivations and SE continuance intention. A theoretical model is developed to explain use and SE continuance intention as intrinsic and extrinsic motivated behaviour, as proposed by self-determination theory. Factors are derived from SE context and supported by published research on SE.Design/methodology/approachThe partial least squares path modelling (PLS-PM) technique is used to test the model in a quantitative study involving 256 users of SE services.FindingsFindings suggest that use and SE continuance can be explained by concurrent intrinsic and extrinsic motivations. Moreover, high environmental concerns may restrain the use of SE services. Findings show that continuance intention is influenced by current use of SE services. Moreover, the study emphasizes the mediation effect of use between intrinsic and extrinsic motivation and SE continuance intention.Research limitations/implicationsThe analysis of use behaviour should be complemented with other measures of use and with data provided by qualitative methods of research. Further research should also consider the effect of different control variables and mediation effects.Practical implicationsBrand managers and companies providing services through digital platforms should address individuals' needs in order to stimulate voluntary engagement in persistent SE practices.Social implicationsThis study informs the consumer in general so that the SE can develop its potential alongside an economy based on the ownership of private property.Originality/valueThis study extends findings on continuance intention research by offering internal motivation factors as predictors of post-adoption behaviour and emphasizes the role of use on SE continuance intention.
Trust and elderly users' continuance intention regarding mobile health services: the contingent role of health and technology anxieties
Authors: Meng Fanbo , Guo Xitong , Peng Zeyu , Ye Qiang , Lai Kee-Hung 
Published: January 2021

PurposeMobile health (mHealth) services are considered an important means of relieving the problems of the aging population. The efficiency of mHealth services can be enhanced by engaging more elderly users and guaranteeing their continued use. However, limited attention has been directed toward investigating elderly users' continuance intention regarding mHealth services. The purpose of this paper is to explain elderly users' continuance intention by investigating the contingent role of technology anxiety and health anxiety on affective trust and cognitive trust.Design/methodology/approachSurvey data were collected from 232 elderly users to verify the research model and hypotheses based on structural equation modeling (SEM).FindingsThis study revealed that both affective and cognitive trust enhance elderly users' continuance intention regarding their use of mHealth services. Health anxiety strengthens the effect of cognitive trust but weakens the effect of affective trust with regard to continuance intention. Furthermore, technology anxiety strengthens the effect of affective trust but not the effect of cognitive trust with regard to continuance intention.Originality/valueThis study is one of the first to examine elderly users' continuance intention regarding mHealth services use from the perspective of affective and cognitive trust, thus enriching the extant literature on the use of mHealth services. Additionally, this study sheds light on the contingent effects of technology anxiety and health anxiety on affective and cognitive trust, which have been neglected by previous research.
Innovation in an authoritarian society: China during the pandemic crisis
Authors: Xiong Jie , Yan Jie , Fu Kun , Wang Ke , He Yuanqiong 
Published: January 2021

Purpose
This paper aims to understand the role of government played in the innovation process during the social crisis, and to investigate the innovation activities of the authoritarian state when dealing with social crisis.

Design/methodology/approach
Secondary data pertaining to eight impactful technological innovations in China during the COVID-19 crisis reveal how interactions and joint efforts by commercial firms and government organizations emerged as spontaneous responses.

Findings
The analysis of eight innovations – health code adoption, health omnichannel construction, noncontact service provision, distance education provision, public emotion consolation service, cross-boundary project promotion, cloud office adoption and medical material production – reveals a matrix of best practices that details the roles of government (controller or endorser) and the value creation orientation (pro-social or pro-economic value).

Originality/value
This study enriches innovation literature by providing a new perspective on the relationship between governmental force and technological innovation during social crises. As these new insights reveal, technological innovation can contribute to social crisis management. China’s example provides helpful implications for other countries suffering from the COVID-19 crisis.