bluuebunny/crossref_metadata_2025_split huggingface dataset:
PETROLEUM GEOLOGY OF THE WESTERN PART OF THE CENTRAL IRAN BASIN
Authors: Abbasi G. , Motamedi H. , Orang K. , Nickandish A. A. 
Published: March 2020

Eocene extension and magmatism in Central Iran was followed by late Eocene – early Oligocene uplift, erosion, volcanism and the deposition of the continental and evaporitic sediments of the Lower Red Formation. During the late Oligocene – early Miocene, an extensional (or transtensional) phase occurred with the deposition of the limestones and marls of the Qom Formation, followed by the evaporitic deposits or mudstones of the basal part of the Upper Red Formation. Since the late Miocene, compression has resulted in regional shortening and uplift, with the deposition of the thick, clastic‐dominated upper part of the Upper Red Formation and the overlying conglomeratic unit.Between 1951 and 2016, a total of 45 exploration, appraisal and development wells were drilled across the western part of the Central Iran Basin where the Alborz, Sarajeh and Aran fields are hydrocarbon discoveries. Traps at these fields are NW‐SE oriented detachment folds formed during the late Miocene – Pliocene. Porous and fractured limestones in the Qom e‐member are the principal reservoir units, and are capped by evaporites or mudstones in the basal part of the Upper Red Formation. Organic‐rich mudstones in the Qom e‐ and c‐members together with shales in the Jurassic Shemshak Formation are potential source rocks.An overview of 80 years of exploration efforts in the western part of the Central Iran Basin suggests that the main reasons for the general lack of success include drilling‐associated problems, poor reservoir characteristics, lack of hydrocarbon charge, and underestimating the thickness of the overburden on top of the Qom reservoir.
Chlorocladiella gen. nov. (Pithophoraceae, Cladophorales, Chlorophyta), Including Four New Species From Various Freshwater Habitats in China
Authors: Zhu Huan , Sun Hui , Zhao Zhijuan , Liu Xudong , Liu Benwen , Hu Zhengyu , Leliaert Frederik , Liu Guoxiang 
Published: March 2020

Samples of Pithophoraceae, collected in diverse freshwater and damp terrestrial habitats from tropical and subtropical China, were characterized morphologically and ultrastructurally, and their phylogenetic position was determined based on nuclear ribosomal DNA sequences. Our phylogenetic analysis resolved a novel lineage of Pithophoraceae, sister to Aegagropilopsis. Based on our phylogenetic results, morphological observations and comparative rDNA ITS2 secondary structure analysis, we propose Chlorocladiella gen. nov., characterized by a well‐developed system of prostrate filaments, and describe four new species, C. cochlea sp. nov., C. erecta sp. nov., C. medogensis sp. nov., and C. pisformis sp. nov. Two species were found growing on damp soil, which is an unusual habitat for cladophoralean green algae, indicating that the diversity of Cladophorales in terrestrial habitats may be greater than currently recognized.
2D shear wave liver elastography by Aixplorer to detect portal hypertension in cirrhosis: An individual patient data meta‐analysis
Authors: Thiele Maja , Hugger Mie B. , Kim Yongsoo , Rautou Pierre‐Emmanuel , Elkrief Laure , Jansen Christian , Verlinden Wim , Allegretti Giulia , Israelsen Mads , Stefanescu Horia , Piscaglia Fabio , García‐Pagán Juan C. , Franque Sven , Berzigotti Annalisa , Castera Laurent , Jeong Woo K. , Trebicka Jonel , Krag Aleksander 
Published: March 2020

AbstractBackground & AimsLiver stiffness measured with 2‐dimensional shear wave elastography by Supersonic Imagine (2DSWE‐SSI) is well‐established for fibrosis diagnostics, but non‐conclusive for portal hypertension.MethodsWe performed an individual patient data meta‐analysis of 2DSWE‐SSI to identify clinically significant portal hypertension (CSPH), severe portal hypertension and large varices in cirrhosis patients, using hepatic venous pressure gradient and upper endoscopy as reference. We used meta‐analytical integration of diagnostic accuracies with optimized rule‐out (sensitivity‐90%) and rule‐in (specificity‐90%) cut‐offs.ResultsFive studies from seven centres shared data on 519 patients. After exclusion, we included 328 patients. Eighty‐nine (27%) were compensated and 286 (87%) had CSPH. 2DSWE‐SSI < 14 kPa ruled out CSPH with a summary AUROC (sROC), sensitivity and specificity of 0.88, 91% and 37%, and correctly classified 85% of patients, with minimal between‐study heterogeneity. The false negative rate was 60%, of which decompensated patients accounted for 78%. 2DSWE‐SSI ≥ 32 kPa ruled in CSPH with sROC, sensitivity, specificity and correct classifications of 0.83, 47%, 89% and 55%. In a subgroup analysis, the 14 kPa cut‐off showed consistent sensitivity and higher specificity for patients with compensated cirrhosis, without ascites, viral aetiology or BMI < 25 kg/m2. 2DSWE‐SSI ruled out severe portal hypertension and large varices with fewer correctly classified and lower sROC, and with minimal benefit for ruling in.ConclusionLiver stiffness using 2‐dimensional shear wave elastography below 14 kPa may be used to rule out clinically significant portal hypertension in cirrhosis patients, but this would need validation in populations of compensated liver disease. 2DSWE‐SSI cannot predict varices needing treatment.
Exogenous cholesterol prevents cryocapacitation‐like changes, membrane fluidity, and enhances in vitro fertility in bubaline spermatozoa
Authors: Rajoriya Jeetendra Singh , Prasad Jai Kishan , Ramteke Snehal Shalik , Perumal Ponraj , De Arun Kumar , Ghosh Subrata Kumar , Bag Sadhan , Raje Archana , Singh Mahak , Kumar Anuj , Kumaresan Arumugam 
Published: March 2020

AbstractA study was conducted to determine the optimum dosage of the exogenous cholesterol‐loaded cyclodextrins (CLC) to get maximum cryoprotection for bubaline spermatozoa. In the present study, 120 × 106 spermatozoa were incubated in 2, 3 and 4 mg of CLC as grouped as Gr II, III and IV, respectively, and sperm progressive motility, intracellular Ca2+, capacitation status by protein tyrosine phosphorylation (PTP) assay and zona binding per cent (ZBP) and cleavage rate (CR) of the cryopreserved buffalo spermatozoa by in vitro fertility assay were assessed in comparison with an untreated control group (Gr I). Results revealed that there was a significant (p < .05) linear decrease in percentage of sperm population with higher intracellular Ca2+ and percentage of sperm population with medium or high capacitated by PTP in CLC treated from 2 to 3 mg and then increased to 4 mg/120 × 106 spermatozoa whereas sperm progressive motility, percentage of sperm population with low capacitated, ZBP and CR were increased significantly (p < .05) in sperm population treated from 2 to 3 mg CLC and then decreased to 4 mg/120 × 106 spermatozoa. The study has clearly indicated that CLC at 3 mg/120 × 106 spermatozoa has maximum beneficial effects in protection of sperm progressive motility, membrane fluidity (low intracellular Ca2+); prevention of cryocapacitation (low capacitation pattern in immunolocalization) and enhancement of in vitro ZBP and CR. Post‐thaw motility of the CLC‐treated sperm has shown positively significant (p < .05) correlation with sperm population with low intracellular Ca2+, low capacitated sperm population, ZBP and CR, whereas it was negatively (p < .05) correlated with sperm population with high intracellular Ca2+, medium or high capacitated sperm. The present study has revealed for the first time that incubation of spermatozoa with CLC of higher dose (>3 mg/120 × 106 spermatozoa) had adverse effects on sperm cryopreservation, although incubation of sperm with 3 mg/120 million prior to processing had minimised the freezing–thawing‐associated damages in bubaline species.
Combination of minimum wiping pressure and number of wipings that can remove pseudo‐skin dirt: A digital image color analysis
Authors: Konya Issei , Shishido Inaho , Ito Yoichi M. , Yano Rika 
Published: March 2020

AbstractBackgroundExcessive wiping friction in skin care may lead to skin damage. Bed baths are required to remove skin dirt without affecting the skin barrier function; the wiping pressure and number of wipings that satisfy these two requirements have not been clarified. This study aimed to determine the minimum wiping pressure and number of wipings that can remove skin dirt.Materials and MethodsIn this quasi‐experimental study, 50 healthy adults received an adhesion of pseudo‐oily and aqueous dirt, randomly assigned to the left and right forearms. Each participant was wiped three times with wiping pressure classified into six randomly assigned categories. The dirt removal rate was calculated by color‐analyzing images captured before and after each wiping, and its dependence on the combination of wiping pressure and number of wipings was assessed using a linear mixed model.ResultsThe combinations achieving oily dirt removal rates of 80% or more were wiping once and pressure ≥50 mmHg, wiping twice and pressure ≥40 mmHg, and wiping thrice and pressure ≥10 mmHg. Aqueous dirt was removed almost completely by wiping once, even with pressure ≥5 mmHg.ConclusionWiping with at least 10 mmHg or more three times can sufficiently remove both oily and aqueous dirt. Dirt removal rates with weak pressure can be made about as effective as those achieved with strong pressure by increasing the number of wipings. This result can be applied to daily nursing, home care, and long‐term care health facilities.
Performance evaluation and modelling of an integrated municipal wastewater treatment system using neural networks
Authors: Mokhtari Habib A. , Bagheri Majid , Mirbagheri Sayed Ahmad , Akbari Ali 
Published: March 2020

AbstractThis study evaluates and models the impacts of employing biofilm carriers in sequencing batch reactors (SBR). A neural network (NN) was used to predict contaminants in the effluent and analyse the importance of operating parameters. With a hydraulic retention time of 7 h, the removal efficiency of chemical oxygen demand (COD), total phosphorous (TP), and total suspended solids (TSS) were 85, 82, and 98.9%, respectively. The removal efficiency of COD, TP, and TSS in our hybrid system was superior to regular single SBR systems. The training procedure of the NN model was successful and almost a perfect match was achieved between predicted values and experimental values. For all models predicting effluent COD, TP, and TSS, the correlation coefficient was higher than 0.99, and mean squared error approached zero. The analysis of input parameters demonstrated that influent concentration is a significant factor in the modelling of effluent characteristics.
Active Flow Control of a Pump-Induced Wall-Normal Vortex With Steady Blowing
Authors: Liu Qiong , An Byungjin , Nohmi Motohiko , Obuchi Masashi , Taira Kunihiko 
Published: March 2020

Abstract
The emergence of a submerged vortex upstream of a pump can reduce pump intake efficiency and cause structural damage. In this study, we consider the use of active flow control with steady blowing to increase the pressure distribution within a single-phase pump-induced wall-normal vortex model, which is based on the Burgers vortex with a no-slip boundary condition prescribed along its symmetry plane. The goal of our control is to modify the vortex core velocity profile. These changes are sought to increase the core pressure such that detrimental effects on the pump are alleviated. Three-dimensional direct numerical simulations are performed to examine the dynamics of the vortex with the application of axial momentum injection at and around the root of the vortex. We find that the active flow control approach can effectively modify the wall-normal vortical structure and significantly increase the low-core pressure by up to 81% compared to that of the uncontrolled case. The result shows that the control setup is also effective when it is introduced in an off-centered manner. Compared to the unsteady blowing and suction-based actuation from our previous work (Liu, Q., An, B., Nohmi, M., Obuchi, M., and Taira, K., 2018, “Core-Pressure Alleviation for a Wall-Normal Vortex by Active Flow Control,” J. Fluid Mech., 853, p. R1.), the current steady control technique offers an effective and simple flow control setup that can support robust operations of pumps.
Short-course antibiotics for chemotherapy-induced febrile neutropaenia: retrospective cohort study
Authors: Seneviratne Nicola , Yeomanson Daniel , Phillips Robert 
Published: March 2020

BackgroundRecent research in febrile neutropaenia (FN) has focused on reducing the intensity of treatment for those thought to be at low risk of significant morbidity or mortality. This has not led to a reduced burden of treatment for either families or healthcare systems. An alternative approach is to discharge all patients who remain well after 48 hours of inpatient treatment, either with no ongoing treatment or with appropriate antibiotics if the cultures are positive. This paper aimed to demonstrate that this approach is safe.MethodsPatients treated according to this approach in a single centre were reviewed retrospectively, with a random selection of patients from a 4-year period. Data were collected according to the Predicting Infectious Complications of Neutropenic sepsis in Children with Cancer dataset. In addition, all septic deaths over a 10-year period were reviewed in the same manner.Results179 episodes of FN were reviewed from 47 patients. In 70% (125/179) of episodes, patients were discharged safely once 48-hour microbiology results were available, with only 5.6% (7/125) resulting in readmission in the 48 hours following discharge. There were no septic deaths in this cohort.There were 11 deaths due to FN over the 10-year study period. Almost all patients were identified as severely unwell in the early stages of their final presentation or had a prolonged final illness.ConclusionThis paper indicates that the policy described provides a balance between safety and acceptability. Further work is needed to demonstrate non-inferiority and cost–benefit.
Incidence of type 2 diabetes in familial combined hyperlipidemia
Authors: Brouwers Martijn C G J , de Graaf Jacqueline , Simons Nynke , Meex Steven , ten Doeschate Sophie , van Heertum Shadana , Heidemann Britt , Luijten Jim , de Boer Douwe , Schaper Nicolaas , Stehouwer Coen D A , van Greevenbroek Marleen M J 
Published: March 2020

ObjectiveFamilial combined hyperlipidemia (FCHL) is common among survivors of a premature myocardial infarction. FCHL patients are characterized by visceral obesity, fatty liver, and insulin resistance. The aim of the present study was to determine the incidence and determinants of type 2 diabetes (T2D) in a longitudinal cohort of FCHL pedigrees.Research design and methodsFCHL patients, their unaffected relatives and spouses included in our baseline cohort in 1998–2005 (n=596) were re-invited to determine the incidence of self-reported T2D (that was confirmed by medical records), used as the primary outcome measure. The Fatty Liver Index (FLI) and Homeostasis Model Assessment Insulin Resistance (HOMA2-IR) were used as markers of fatty liver and insulin resistance, respectively. A subset of the original cohort underwent ultrasound of the liver, and subcutaneous and visceral fat in 2002–2005 (n=275; ‘ultrasound subcohort’).ResultsFollow-up data (median: 15 years) was acquired for 76%. The incidence rate of T2D was significantly higher in FCHL patients compared with spouses (19.2 per 1000 person-years vs 2.8 per 1000 person-years; HR : 6.3, 95% CI: 2.4 to 16.8), whereas no differences were observed between unaffected relatives and spouses (HR: 0.9, 95% CI: 0.3 to 2.6). Cox’s proportional hazard regression analyses showed that baseline HOMA2-IR and FLI≥60, but not waist circumference, BMI, or the FCHL affected state, were independently associated with incident T2D. Similar results were obtained in the ultrasound subcohort (median follow-up: 11 years), in which baseline HOMA2-IR and fatty liver (assessed by ultrasound) were independently associated with incident T2D.ConclusionThis study further corroborates the suggestion that the liver plays a central role in the pathogenesis of cardiometabolic complications in FCHL. It supports periodical screening for T2D in this high-risk population.
Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population
Authors: Feng Lei , Nian Shiyan , Tong Zongwu , Zhu Ying , Li Ying , Zhang Chunting , Bai Xuejing , Luo Xuan , Wu Mengna , Yan Zefeng 
Published: March 2020

ObjectivesThis study aimed to investigate the dynamic trends in total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels with ageing.DesignA Chinese population-based cross-sectional study.SettingA physical examination centre of a general hospital.ParticipantsAdult subjects (178 167: 103 461 men and 74 706 women) without a known medical history or treatments that affect lipid metabolism.Main outcome measuresDynamic trends in the above-mentioned lipid parameters with ageing were explored; turning points of age were established using age stratification and validated by fitted multivariate linear regression modelling.ResultsAge was found to be an independent factor extensively associated with lipid levels in both sexes when adjusted for serum glucose, body mass index, lifestyle, drinking and smoking. Age was positively associated with TC, logarithm-transformed TG (LnTG) and LDL-C levels in men ≤40, ≤40 and ≤60 years old (yo) and in women ≤60, ≤70 and ≤60 yo, respectively. Conversely, age correlated negatively with TC, LnTG and LDL-C levels in men ≥61, ≥41 and ≥61 yo and in women ≥61, ≥71 and ≥61 yo, respectively. TC, TG and LDL-C levels in women were initially lower than those in men but surpassed those in men in 51–55, 61–65 and 51–55 yo age groups. The trends in HDL-C levels with age were relatively irregular, although HDL-C levels in women were higher than in men for all age groups.ConclusionsThe definition of dyslipidaemia, the atherosclerotic cardiovascular disease risk assessment and the initiation/goals of statin therapy should fully consider age-related trends in lipid levels and sex differences.
Implementing a hybrid cognitive-behavioural therapy for pain-related insomnia in primary care: lessons learnt from a mixed-methods feasibility study
Authors: Tang Nicole K Y , Moore Corran , Parsons Helen , Sandhu Harbinder Kaur , Patel Shilpa , Ellard David R , Nichols Vivien P , Madan Jason , Collard Victoria Elizabeth Janet , Sharma Uma , Underwood Martin 
Published: March 2020

ObjectivesTo test the feasibility of implementing a brief but intensive hybrid cognitive behavioural therapy (Hybrid CBT) for pain-related insomnia.DesignMixed-methods, with qualitative process evaluation on a two-arm randomised controlled feasibility trial.SettingPrimary care.ParticipantsTwenty-five adult patients with chronic pain and insomnia.InterventionHybrid CBT or self-help control intervention.Primary and secondary outcome measuresPrimary outcomes measures were the Insomnia Severity Index and interference scale of the Brief Pain Inventory (BPI). Secondary outcomes measures were the present pain intensity rating from the BPI, Multidimensional Fatigue Inventory, Hospital Anxiety and Depression Scale and EQ-5D-5L.ResultsFourteen participants were randomised to receive Hybrid CBT, 11 to receive the self-help control treatment. Of the 14 in the Hybrid CBT group, 9 (64%) completed all four treatment sessions (4 discontinued due to poor health; 1 due to time constraints). Adherence to the self-help control treatment was not monitored. The total number of participants completing the 12-week and 24-week follow-ups were 12 (6 in each group; Hybrid CBT: 43%; self-help: 55%) and 10 (5 in each group; Hybrid CBT: 36%; self-help: 45%). Based on the data available, candidate outcome measures appeared to be sensitive to changes associated with interventions. Thematic analysis of pre-postintervention interview data revealed satisfaction with treatment content among those who completed the Hybrid CBT, whereas those in the self-help control treatment wanted more contact hours and therapist guidance. Other practical suggestions for improvement included shortening the duration of each treatment session, reducing the amount of assessment paperwork, and minimising the burden of sleep and pain monitoring.ConclusionImportant lessons were learnt with regard to the infrastructure required to achieve better patient adherence and retention. Based on the qualitative feedback provided by a subset of treatment completers, future trials should also consider lowering the intensity of treatment and streamlining the data collection procedure.Trial registration numberISRCTN17294365.
Global eye health and the sustainable development goals: protocol for a scoping review
Authors: Zhang Justine H , Ramke Jacqueline , Mwangi Nyawira , Furtado João , Yasmin Sumrana , Bascaran Covadonga , Ogundo Cynthia , Jan Catherine , Gordon Iris , Congdon Nathan , Burton Matthew J 
Published: March 2020

IntroductionIn 2015, most governments of the world committed to achieving 17 sustainable development goals (SDGs) by the year 2030. Efforts to improve eye health contribute to the advancement of several SDGs, including those not exclusively health-related. This scoping review will summarise the nature and extent of the published literature that demonstrates a link between improved eye health and advancement of the SDGs.Methods and analysisSearches will be conducted in MEDLINE, Embase and Global Health for published, peer-reviewed manuscripts, with no time period, language or geographic limits. All intervention and observational studies will be included if they report a link between a change in eye health and (1) an outcome related to one of the SDGs or (2) an element on a pathway between eye health and an SDG (eg, productivity). Two investigators will independently screen titles and abstracts, followed by full-text screening of potentially relevant articles. Reference lists of all included articles will be examined to identify further potentially relevant studies. Conflicts between the two independent investigators will be discussed and resolved with a third investigator. For included articles, data regarding publication characteristics, study details and SDG-related outcomes will be extracted. Results will be synthesised by mapping the extracted data to a logic model, which will be refined through an iterative process during data synthesis.Ethics and disseminationAs this scoping review will only include published data, ethics approval will not be sought. The findings of the review will be published in an open-access, peer-reviewed journal. A summary of the results will be developed for website posting, stakeholder meetings and inclusion in the ongoing Lancet Global Health Commission on Global Eye Health.