bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal Integrity and Spontaneous Nonlinear Dynamic Properties of the Salience Network Revealed by Human Intracranial Electrophysiology: A Multicohort Replication
Authors: Das Anup , Menon Vinod 
Published: April 2020

Abstract
The salience network (SN) plays a critical role in cognitive control and adaptive human behaviors, but its electrophysiological foundations and millisecond timescale dynamic temporal properties are poorly understood. Here, we use invasive intracranial EEG (iEEG) from multiple cohorts to investigate the neurophysiological underpinnings of the SN and identify dynamic temporal properties that distinguish it from the default mode network (DMN) and dorsolateral frontal–parietal network (FPN), two other large-scale brain networks that play important roles in human cognition. iEEG analysis of network interactions revealed that the anterior insula and anterior cingulate cortex, which together anchor the SN, had stronger intranetwork interactions with each other than cross-network interactions with the DMN and FPN. Analysis of directionality of information flow between the SN, DMN, and FPN revealed causal outflow hubs in the SN consistent with its role in fast temporal switching of network interactions. Analysis of regional iEEG temporal fluctuations revealed faster temporal dynamics and higher entropy of neural activity within the SN, compared to the DMN and FPN. Critically, these results were replicated across multiple cohorts. Our findings provide new insights into the neurophysiological basis of the SN, and more broadly, foundational mechanisms underlying the large-scale functional organization of the human brain.
The Changing Patterns of Coronavirus Disease 2019 (COVID-19) in China: A Tempogeographic Analysis of the Severe Acute Respiratory Syndrome Coronavirus 2 Epidemic
Authors: Tang Weiming , Liao Huipeng , Marley Gifty , Wang Zaisheng , Cheng Weibin , Wu Dan , Yu Rongbinand 
Published: April 2020

Abstract

Background
Evaluating whether an infectious disease has reached a turning point is important for planning additional intervention efforts. This study aimed to analyze the changing patterns and the tempogeographic features of the coronavirus disease 2019 (COVID-19) epidemic in China, to provide further evidence for real-time responses.

Methods
Daily data on COVID-19 cases between 31 December 2019 and 26 February 2020 were collected and analyzed for Hubei and non-Hubei regions in China. Observed trends for new and cumulative cases were analyzed through joinpoint regression analysis. Spatial analysis was applied to show the geographic distribution and changing patterns of the epidemic.

Results
By 26 February 2020, 78 630 confirmed COVID-19 cases had been reported in China. In Hubei, an increasing trend (slope = 221) was observed for new cases between 24 January and 7 February 2020, after which a decline commenced (slope = −868). However, as the diagnosis criteria changed, a sudden increase (slope = 5530) was observed on 12 February, which sharply decreased afterward (slope = −4898). In non-Hubei regions, the number of new cases increased from 20 January to 3 February and started to decline afterward (slope = −53). The spatial analysis identified Chongqing, Guangzhou, Shenzhen, Changsha, Nanchang, Wenzhou, Shanghai, Xinyang, Jining, and Beijing as the hotspots outside of Hubei Province in China.

Conclusions
The joinpoint regression analysis indicated that the epidemic might be under control in China, especially for regions outside of Hubei Province. Further improvement in the response strategies based on these new patterns is needed.
Dispute Settlement in the Belt and Road Initiative: Progress, Issues, and Future Research Agenda
Authors: Wang Jiangyu 
Published: April 2020

Abstract
Policy-makers in China for the Belt and Road Initiative (BRI) initially did not consider dispute settlement very seriously, but they have realized in recent years that this is an issue that might have to form a critical part of BRI transactions and projects. This introduction gives an overview of the types of disputes emerging out of the BRI deals and critically examines China’s efforts to build institutions and rules for resolving BRI disputes. In this context, it introduces the articles contained in this special issue and presents a future research agenda for moving the study of BRI dispute settlement to the next level.
Blood stream infection and outcomes in recipients of a left ventricular assist device
Authors: Angleitner Philipp , Matic Aleksa , Kaider Alexandra , Dimitrov Kamen , Sandner Sigrid , Wiedemann Dominik , Riebandt Julia , Schlöglhofer Thomas , Laufer Günther , Zimpfer Daniel 
Published: April 2020

Abstract

OBJECTIVES

Our aim was to investigate associations between blood stream infection [≥1 positive blood culture (BC)] and outcomes in recipients of a left ventricular assist device (LVAD).

METHODS
We retrospectively analysed all adult recipients of a continuous-flow LVAD between 2006 and 2016 at the Division of Cardiac Surgery, Medical University of Vienna (n = 257; devices: Medtronic HeartWare® HVAD®, Abbott HeartMate II®, Abbott HeartMate 3™). The primary outcome was all-cause mortality during follow-up. Secondary outcomes included the risk of stroke and pump thrombus during follow-up as well as the probability of heart transplantation (HTx). Risk factors for the development of ≥1 positive BC were evaluated additionally.

RESULTS
The incidence of ≥1 positive BC during the first year of LVAD support was 32.1% [95% confidence interval (CI) 26.4–37.9]. Multivariable Cox proportional cause-specific hazards regression analysis showed that a positive BC was associated with significantly increased all-cause mortality [hazard ratio (HR) 5.51, 95% CI 3.57–8.51; P &lt; 0.001]. Moreover, a positive BC was associated with a significantly increased risk of stroke (HR 2.41, 95% CI 1.24–4.68; P = 0.010). There was no association with the risk of pump thrombus or the probability of HTx. Independent risk factors for a positive BC included preoperative albumin and extracorporeal membrane oxygenation/intra-aortic balloon pump support.

CONCLUSIONS
Blood stream infection is common and associated with a significantly increased risk of all-cause mortality and stroke at any given time during LVAD support. Effective strategies of prevention and treatment are necessary.
Minimally invasive access type related to outcomes of sutureless and rapid deployment valves
Authors: Andreas Martin , Berretta Paolo , Solinas Marco , Santarpino Giuseppe , Kappert Utz , Fiore Antonio , Glauber Mattia , Misfeld Martin , Savini Carlo , Mikus Elisa , Villa Emmanuel , Phan Kevin , Fischlein Theodor , Meuris Bart , Martinelli Gianluca , Teoh Kevin , Mignosa Carmelo , Shrestha Malakh , Carrel Thierry P , Yan Tristan , Laufer Guenther , Di Eusanio Marco 
Published: April 2020

Abstract

OBJECTIVES
Minimally invasive surgical techniques with optimal outcomes are of paramount importance. Sutureless and rapid deployment aortic valves are increasingly implanted via minimally invasive approaches. We aimed to analyse the procedural outcomes of a full sternotomy (FS) compared with those of minimally invasive cardiac surgery (MICS) and further assess MICS, namely ministernotomy (MS) and anterior right thoracotomy (ART).

METHODS
We selected all isolated aortic valve replacements in the Sutureless and Rapid Deployment Aortic Valve Replacement International Registry (SURD-IR, n = 2257) and performed propensity score matching to compare aortic valve replacement through FS or MICS (n = 508/group) as well as through MS and ART accesses (n = 569/group).

RESULTS
Postoperative mortality was 1.6% in FS and MICS patients who had a mean logistic EuroSCORE of 11%. Cross-clamp and cardiopulmonary bypass (CPB) times were shorter in the FS group than in the MICS group (mean difference 3.2 and 9.2 min; P &lt; 0.001). Patients undergoing FS had a higher rate of acute kidney injury (5.6% vs 2.8%; P = 0.012). Direct comparison of MS and ART revealed longer mean cross-clamp and CPB times (12 and 16.7 min) in the ART group (P &lt; 0.001). The postoperative outcome revealed a higher stroke rate (3.2% vs 1.2%; P = 0.043) as well as a longer postoperative intensive care unit [2 (1–3) vs 1 (1–3) days; P = 0.009] and hospital stay [11 (8–16) vs 8 (7–12) days; P &lt; 0.001] in the MS group than in the ART group.

CONCLUSIONS
According to this non-randomized international registry, FS resulted in a higher rate of acute kidney injury. The ART access showed a lower stroke rate than MS and a shorter hospital stay than all other accesses. All these findings may be related to underlying patient risk factors.
Dynamic Systems, Contextual Influences, and Multiple Timescales: Emotion Regulation as a Resilience Resource
Authors: Bergeman Cindy S , Blaxton Jessica , Joiner Raquael 
Published: April 2020

Abstract
We need to understand how psychosocial resources develop, identify the influences that threaten their maintenance, detect the circumstances under which these resources are used, and elucidate the factors that support and promote their growth. Three important components to studying the development of resilience include its dynamic nature, context, and timescale of measurement. Dynamic systems (DS) approaches focus on physiological and psychological structures underling the development of resilience by explicitly mapping parameters of change onto their corresponding aspects of functioning. Previous research has captured emotion regulation within individuals, across traits, and in close personal relationships to show how these methods depict dynamic regulation/resilience resources and their influence on outcomes of interest. The use of multi-time scaled data informs how daily emotion regulation is disrupted in the context of stress to produce dysregulation and disease later in the life course. This approach can also reveal how resilience resources counteract these adverse processes and allow others to thrive and be well. Researchers must not only explore short-term variation in constructs of interest, but also explore how these shorter-term fluctuations contribute to longer-term changes. The confluence of DS, contextual influences, and multiple timescales provides an important set of tools to better understand development.
Seasonal and interannual variation in spatio-temporal models for index standardization and phenology studies
Authors: Thorson James T , Adams Charles F , Brooks Elizabeth N , Eisner Lisa B , Kimmel David G , Legault Christopher M , Rogers Lauren A , Yasumiishi Ellen M 
Published: April 2020

AbstractClimate change is rapidly affecting the seasonal timing of spatial demographic processes. Consequently, resource managers require information from models that simultaneously measure seasonal, interannual, and spatial variation. We present a spatio-temporal model that includes annual, seasonal, and spatial variation in density and then highlight two important uses: (i) standardizing data that are spatially unbalanced within multiple seasons and (ii) identifying interannual changes in seasonal timing (phenology) of population processes. We demonstrate these uses with two contrasting case studies: three bottom trawl surveys for yellowtail flounder (Limanda ferruginea) in the Northwest Atlantic Ocean from 1985 to 2017 and pelagic tows for copepodite stage 3+ copepod (Calanus glacialis/marshallae) densities in the eastern Bering Sea from 1993 to 2016. The yellowtail analysis illustrates how data from multiple surveys can be used to infer density hot spots in an area that is not sampled one or more surveys. The copepod analysis assimilates seasonally unbalanced samples to estimate an annual index of the seasonal timing of copepod abundance and identifies a positive correlation between this index and cold-pool extent. We conclude by discussing additional potential uses of seasonal spatio-temporal models and emphasize their ability to identify climate-driven shifts in the seasonal timing of fish movement and ecosystem productivity.
Non-ischaemic intramyocardial dissection following total arch replacement
Authors: Wakatabe Makoto , Kotani Sohsyu , Inoue Yoshito 
Published: April 2020

Abstract
Intramyocardial dissection (ID) is a rare left ventricular (LV) disorder characterized by myocardial fibre dissection and neocavitation. In this study, we present a rare case of a 66-year-old woman who had a history of sarcoidosis with non-ischaemic ID following total arch replacement. ID developed suddenly in the free wall of the LV and expanded rapidly to form an LV aneurysm. We successfully performed LV reconstructive surgery to prevent ID rupture.
Ecological efficiency management of tourism scenic spots based on carbon footprint analysis
Authors: Li Yang , Zhang Lei 
Published: April 2020

Abstract
The analysis of carbon footprint plays an important role in the management of tourism scenic spots. This paper first introduced the calculation method of carbon footprint and ecological efficiency value of tourism scenic spots, then analyzed the general situation of tourism scenic spots in Jiangsu province and collected the data of 2013–17 to calculate the carbon footprint and ecological efficiency value. The results showed that the carbon footprint of tourism scenic spots in Jiangsu province was increasing year by year, of which the traffic carbon footprint accounted for the largest proportion, 60%. The value of ecological benefits of accommodation was the largest, followed by catering, activities and transportation, and accommodation created the highest economic benefits. According to the calculation results, some suggestions were put forward for the ecological efficiency management of tourism scenic spots in Jiangsu province, which is conducive to the better development of tourism scenic spots.
Rapid diagnostic tests for common infection syndromes: less haste, more speed
Authors: Patel S V , Pulcini C , Demirjian A , van Hecke O 
Published: April 2020

Abstract
Rapid diagnostic tests, which accurately distinguish bacterial from viral infections, are being heralded as the solution to antibiotic overuse, which is a key driver of antimicrobial resistance. We have concerns that this approach is oversimplistic. Rapid diagnostic tests are complex interventions, with clinical context, patient flow, access and timing affecting their impact. There is little robust evidence that they reduce antibiotic prescribing in real-world settings. We suggest that prior to introducing these costly tests, emphasis should be placed on optimizing the implementation of efficient evidence-based antimicrobial stewardship interventions, such as increasing the use of proven automated clinical infection syndrome prediction tools by clinicians, supporting patients to self-care by providing them with high-quality safety-netting resources, providing front-line clinicians with individual prescribing data to facilitate peer benchmarking and setting specific and purposeful antibiotic prescribing targets to improve the quality of antimicrobial prescribing. The stakes are high and time is running out; let’s start by getting the basics right.
Neuroendocrine carcinoma of the ampulla of Vater: a case report, review and recommendations
Authors: Kleinschmidt Thomas K , Christein John 
Published: April 2020

AbstractNeuroendocrine tumor (NET) of the ampulla of Vater is a rare presentation of biliary obstruction. Here, we present a case of NET and discuss the current recommendations that necessitate different management and surgical treatment than other sites. A 56-year-old Caucasian female presented with 2 years of right upper quadrant pain. Workup revealed a well-differentiated 2.2 cm NET at the ampulla with 0 MF/10 HPF, Stage 1A T2NOMO. Whipple procedure performed with 2.2 cm ampullary NET with 1 of the 15 lymph node metastases and &lt;2 mitoses in 10 HPF. TNM classification: Stage IV T2N1MO. Regardless of tumor size, NETs metastasize in half of cases. Local excisions including endoscopic and laparoscopic ampullectomy were recommended only for poor surgical candidates. Ampullary NETs behave more aggressively than nonampullary NETs and their biological behaviors are irrespective of size. For patients of acceptable surgical risk, we recommend radical resection utilizing Whipple procedure.
Philosophy of energy and energy transition in the age of the petro-Anthropocene†
Authors: Heurtebise Jean-Yves 
Published: April 2020

Abstract
The purpose of this article is to present the multidimensional issue of an ‘energy transition’ from a philosophical, that is, conceptual and analytical, point of view. The argument of this article is that ‘energy transition’ is not simply a technological and economic problem but also an epistemological, cultural, anthropological and even metaphysical one. Energy transition does not only consist of changing the kind of energy that is produced and consumed to power our modern middle-income societies, from fossil fuels to renewable energies. Energy transition asks us to understand what is implied in cultural and social terms by such a shift from ‘grey’ to ‘green’ sources of energy that does not only entail qualitative transformation but also could imply quantitative curtailment. What will be the consequences of our necessary departure from ‘petromodernity’, that is, from the mode of living that came with fossil fuels in modern times that shape our current age of the Anthropocene? To address this question, different dimensions of the philosophy of energy will be studied: epistemological, phenomenological, anthropological, critical and metaphysical. In conclusion, we will, first, propose the notion of a ‘negative energy tax’ to address the problems of ‘energy injustice’. We will then refer to Bataille to provide an ontology of energy that can help to redefine our assumptions and expectations regarding energy spending.
The sequence and thresholds of leaf hydraulic traits underlying grapevine varietal differences in drought tolerance
Authors: Dayer Silvina , Herrera José Carlos , Dai Zhanwu , Burlett Régis , Lamarque Laurent J , Delzon Sylvain , Bortolami Giovanni , Cochard Hervé , Gambetta Gregory A 
Published: April 2020

AbstractAdapting agriculture to climate change is driving the need for the selection and breeding of drought-tolerant crops. The aim of this study was to identify key drought tolerance traits and determine the sequence of their water potential thresholds across three grapevine cultivars with contrasting water use behaviors, Grenache, Syrah, and Semillon. We quantified differences in water use between cultivars and combined this with the determination of other leaf-level traits (e.g. leaf turgor loss point, π TLP), leaf vulnerability to embolism (P50), and the hydraulic safety margin (HSM P50). Semillon exhibited the highest maximum transpiration (Emax), and lowest sensitivity of canopy stomatal conductance (Gc) to vapor pressure deficit (VPD), followed by Syrah and Grenache. Increasing Emax was correlated with more negative water potential at which stomata close (Pgs90), π TLP, and P50, suggesting that increasing water use is associated with hydraulic traits allowing gas exchange under more negative water potentials. Nevertheless, all the cultivars closed their stomata prior to leaf embolism formation. Modeling simulations demonstrated that despite a narrower HSM, Grenache takes longer to reach thresholds of hydraulic failure due to its conservative water use. This study demonstrates that the relationships between leaf hydraulic traits are complex and interactive, stressing the importance of integrating multiple traits in characterizing drought tolerance.
Gametophyte-specific DEAD-box RNA helicase 29 is required for functional maturation of male and female gametophytes in Arabidopsis
Authors: Chen Dan , Wang Yameng , Zhang Wen , Li Na , Dai Bo , Xie Fei , Sun Yang , Sun Mengxiang , Peng Xiongbo 
Published: April 2020

Abstract
The maturation of male and female gametophytes together with its impact on plant sexual reproduction has not received much attention, and the molecular mechanisms underlying the process are largely unknown. Here, we show that Arabidopsis DEAD-box RNA helicase 29 (RH29) is critical for the functional maturation of both male and female gametophytes. Homozygous rh29 mutants could not be obtained, and heterozygous mutant plants were semi-sterile. Progression of the cell cycle in rh29 female gametophytes was delayed. Delayed pollination experiments showed that rh29 female gametophytes underwent cell-fate specification but were unable to develop into functional gametophytes. Functional specification but not morphogenesis was also disrupted in rh29 male gametophytes, causing defective pollen tube growth in the pistil. RH29 was highly and specifically expressed in gametophytic cells. RH29 shares high amino acid sequence identity with yeast Dbp10p, which partially rescues the aborted-ovules phenotype of rh29/RH29 plants. RH29 is essential for the synthesis of REGULATORY PARTICLE TRIPLE A ATPase 5a (RPT5a), a subunit of the regulatory particle of the 26S proteasome. Our results suggest that gametophyte functional maturation is a necessary process for successful fertilization and that RH29 is essential for the functional maturation of both male and female gametophytes.
The effects of parasite exposure on mortality from aquatic contaminants, carbaryl and elevated salinity, in a freshwater crustacean
Authors: Ilmain Juliana K , Searle Catherine L 
Published: April 2020

Abstract
Freshwater pollution is a major global concern. Common methods for determining the effects of contaminants on freshwater organisms involve short-term laboratory experiments with otherwise healthy organisms. However, in natural systems, organisms are commonly exposed to parasites, which could alter their ability to survive exposure to aquatic contamination. We used a freshwater crustacean (Daphnia dentifera) to quantify the effects of parasite exposure on mortality from two common freshwater contaminants (elevated salinity [NaCl] and carbaryl). In our salinity trial, both parasite exposure and elevated salinity reduced survival in an additive manner. In our carbaryl trial, exposure to carbaryl reduced survival and we found a less-than-additive (i.e. antagonistic) interaction between carbaryl and the parasite; the parasite only reduced survival in the control (no carbaryl) treatments. Our results demonstrate that parasites and contaminants can jointly affect mortality in aquatic organisms in an additive or less-than-additive manner.
Toward experimental observations of induced Compton scattering by high-power laser facilities
Authors: Tanaka Shuta J , Yamazaki Ryo , Kuramitsu Yasuhiro , Sakawa Youichi 
Published: April 2020

Abstract
Induced Compton scattering (ICS) is a nonlinear interaction between intense electromagnetic radiation and a rarefied plasma. Although the magnetosphere of pulsars is a potential site at which ICS occurs in nature, ICS signatures have not been discovered so far. One of the reasons for the non-detection of ICS signatures is that we still do not possess a concrete understanding of such nonlinear plasma interactions because of their nonlinear nature and the lack of experimental confirmations. Here, we propose a possible approach to understand ICS experimentally in laboratories, specifically, with the use of the up-to-date short-pulse lasers. We find that the scattered light of ICS has characteristic signatures in its spectrum. The signatures will be observed in some current laser facilities. The characteristic spectrum is quantitatively predictable and we can diagnose the properties of the scattering plasma from the signatures.