bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pollen Beads: A New Carrier for Propolis Active Compounds
Authors: Keskin Şaban , Trusheva Boryana , Popova Milena , Kolaylı Sevgi , Bankova Vassya 
Published: July 2020

Background:
Pollen and propolis are two bee products with highly health promoting
properties. But there are some limitations of raw propolis usage not only in daily consumption but
also in putting it in food formulations. Propolis should be extracted to convert it into consumable
form and ethanol is the first choice as a solvent. But ethanol consumption, either in health-wise or
religious aspect, is one of the factors limiting the usage of propolis extract. The strong taste and
strong smell of propolis are other factors. The immobilization of propolis active compounds could
be a tool for overcoming either all or some of these factors.

Objective:
This study was aimed at immobilization of propolis active constituents on the surface of whole pollen grains.

Methods:
Chemical composition of raw propolis was determined by using GC-MS technique. Total
phenolic content and antioxidant activity of the samples were measured spectrophotometrically. The
release property of the beads was determined.

Results:
Immobilization efficiency was 53%. Total phenolic and flavonoid content of pollen,
propolis and pollen-propolis beads were measured. It was determined that pollen-propolis beads
contain more phenolics than pollen and propolis itself. Ferric reducing activity of the samples was
also investigated and pollen-propolis beads showed better activity. Release behavior of pollen and
pollen-propolis beads was studied in simulated digestive systems. Better release properties of
pollen-propolis beads were achieved in all tested systems as well. These findings support the
immobilization of propolis active compounds on the surface of whole pollen grains.

Conclusion:
It could be concluded that the product obtained, pollen-propolis beads, could be
considered as a more valuable healthy product since the synergistic action of pollen and propolis.
Momordica charantia Seed and Aryl Extracts Potentiate Growth Inhibition and Apoptosis by Dual Blocking of PI3K/AKT and MAPK Pathways as a Downstream Target of EGFR Signaling in Breast Cancer Cells
Authors: Basaran Guzide Satir , Bekci Hatice , Baldemir Ayse , Ilgun Selen , Cumaoglu Ahmet 
Published: July 2020

Background and Objective:
Herbal extracts and plant compounds are increasingly becoming
of interest for their therapeutic potential in various cancer types. Momordica charantia is well
known for its anti-diabetic, anti-inflammatory, and anti-cancer properties.

Methods:
In the present study, we investigated the antiproliferative and pro-apoptotic effects of
Momordica charantia seed and aryl extracts on breast cancer cells and explored the underlying
molecular mechanisms.

Results:
Our results showed that both extract significantly inhibited the growth of MCF-7 and MDA
MB-231 cells in a concentration-dependent manner, and induced apoptosis by upregulation of caspase
9 and caspase 3 mRNA levels. In addition, in different incubation time, both extract evidently inhibited
EGF and induced EGFR phosphorylation/activation in both cell lines. Moreover, Momordica
charantia aryl and seed extracts inhibited phosphorylation/activation of PI3K/AKT and MAPK
(ERK and P38) pathways in both cell lines.

Conclusion:
The current study clearly demonstrates that the Momordica charantia aryl and seed extracts
have the potential to exert its cytotoxic effect on breast cancer cells by a mechanism involving
inhibition of EGFR and EGRF related pathways with the induction of apoptosis. The overall finding
demonstrates that this plant, especially seed extract, could be a potential source of new anticancer
compounds for possible drug development against cancer.
Association Between Magnesium and Oxidative Stress in Patients with Obesity
Authors: de Oliveira Ana R.S. , Cruz Kyria J.C. , Morais Jennifer B.S. , Severo Juliana S. , Beserra Jéssica B. , dos Santos Loanne R. , de Sousa Melo Stéfany R. , Luz Larissa M. , de Sousa Leidejaira A. , de Matos Neto Emídio M. , de Jesus e Silva de Almendra Freitas Betânia , do Nascimento Nogueira Nadir , do Nascimento Marreiro Dilina 
Published: July 2020

Background:
The role of minerals in preventing the generation of oxidative stress in
obese individuals has been evaluated. Magnesium is an antioxidant nutrient and a cofactor of enzymes
involved in the cell membrane stabilization, attenuating the effects of oxidative stress.

Objective:
To evaluate the association between magnesium and concentrations of thiobarbituric acid
reactive substances (TBARS) in patients with obesity and eutrophic women.

Methods:
A cross-sectional study was conducted with 73 women, divided into two groups: case
group (patients with obesity, n=27) and control group (eutrophic women, n=46). Measurements of
body mass index and waist circumference were performed. Dietary magnesium intake was assessed
by the three-day food record using the NutWin software. Urinary magnesium concentration was
measured by atomic absorption spectrophotometry method. Plasma concentrations of thiobarbituric
acid reactive substances (TBARS) were also determined.

Results:
Mean values of dietary magnesium intake were 161.59 ± 60.04 and 158.73 ± 31.96 for patients
with obesity and control group, respectively, with no significant difference between the groups
studied (p >0.05). The value of urinary excretion of magnesium was lower than the reference values
in both groups, with no significant difference between the groups studied (p >0.05). The plasma concentration
of thiobarbituric acid reactive substances was significantly higher in patients with obesity
compared to the control group (p <0.001). There was no correlation between levels of magnesium
biomarkers and the concentration of TBARS (p >0.05).

Conclusion:
Patients with obesity showed a reduced dietary magnesium intake which seems to induce
hypomagnesuria as a compensatory mechanism. The marker of oxidative stress evaluated in this
study was not influenced by magnesium.
COVID-19 in Dental Practice: Transmission Risk, Infection Control Challenge, and Clinical Implications
Authors: Aldahlawi Salwa A. , Afifi Ibtesam K. 
Published: July 2020

Objective:
The COVID-19 pandemic has become a worldwide, significant public health challenge. Dental care providers are at high risk due to the nature of their profession, which necessitates close proximity to the patient's oropharyngeal region and the use of droplet and aerosol-generating procedures.

Methods:
A review of the evolving literature on the COVID-19 pandemic was conducted. Published articles addressing SARS-CoV2 transmission modes and risks, and infection control procedures required in the dental office to protect dental patients and health care providers were assessed. Also, clinical guidelines on the management of dental patients during the pandemic were reviewed.

Results:
The established modes of transmission of SARS-CoV2 appear to be through respiratory droplets and through close contact with either symptomatic or asymptomatic patients. In addition to standard precautions of infection control widely followed in dental practices, extra precautionary measures are needed to control the spread of this highly infectious disease. Dental treatment during the pandemic is limited to emergent and urgent cases after a meticulous patient risk assessment and dental needs are triaged to minimize the risk of COVID-19 transmission and avoid cross-contamination.

Conclusion:
Dentists should be aware of the recently updated knowledge about COVID-19 modes of transmission and the recommended infection control measures in dental settings. Effective management protocols to regulate droplet and aerosol contamination in the dental clinic should be implemented to deliver dental care in a safe environment.
Evaluation of Prognostic Factors Associated with Postoperative Complications Following Pulmonary Hydatid Cyst Surgery
Authors: Ahmadinejad Mojtaba , Hashemi Mozaffar , Azizallahi Nasim 
Published: July 2020

Background:
Hydatid cysts are one of the serious complications following echinococcus infection. The liver and the lungs are the most affected organs, respectively. The severity of the disease is associated with the increase in the number and the size of the cysts, cysts rupture, and systemic effects. The aim of this study is to evaluate prognostic factors that are associated with the increased incidence of postoperative complications following pulmonary hydatid cyst surgery.

Methods:
Patients referred to Madani hospital from 2014-2018, presenting pulmonary hydatid cysts were included in this study. All the patients were evaluated based on the following parameters: age, gender, location and size of the cysts, rupture status of the cysts (intact or perforated), type of surgical intervention (capitonnage or segmentectomy) and Erythrocyte Sedimentation Rate (ESR). The factors were then compared with postoperative complications. Statistical analysis of the data obtained was conducted using R-software

Results:
Of 76 patients enrolled in our study, 52.63% were males and 47.36% were female. Air leak complication was reported in 13.15% of the patients and 3.94% of the patients were presented with pleural effusion. Postoperative complications were significantly associated with the perforated (ruptured) cysts p= 0.001, segmentectomy p= 0.013, giant hydatid cysts p= 0.007 and ESR p= 0.014. However, the side of the lung was not significantly related to postoperative complications.

Conclusion:
Our study reports that perforated cysts, increased size, segmentectomy and abnormal ESR are likely to increase postoperative complications following pulmonary hydatid cysts surgery. Prospective studies with perioperative parameters and greater sample size can help to deduce better inferences.
Physical and Mechanical Properties of Hempcrete
Authors: Demir İsmail , Doğan Cüneyt 
Published: July 2020

Background:Environment-friendly materials attract attention whilst the construction sector causes excessive global energy consumption and emission of greenhouse gas. Renewable plant-based biomaterials, which have a low environmental impact, are very beneficial in order to prevent environmental pollution and to preserve natural resources. Hempcrete provides environment-friendly construction materials as well as thermal and hygroscopic properties.Objective:This paper presents a review of hempcrete research about understanding the environmental effects and construction methods of hempcrete; moreover, the benefits and innovations it has provided throughout its life cycle, have been investigated.Methods:For this purpose, experimental studies of hempcrete were compared to each other in all aspects in order to determine density, thermal conductivity, vapor permeability, hygrometric behavior, durability, acoustic absorption, mechanical properties and life cycle analysis. Moreover, binder characteristics, hemp shiv proportions, water content, curing conditions and results have been focused on to explain the benefits of hempcrete.Results:The results obtained show that hempcrete has high porosity and vapor permeability, medium-low density, low thermal conductivity, Young’s modulus and compressive strength.Conclusion:Based upon the findings of the studies reviewed, hempcrete is an advantageous material in buildings with its extraordinary thermal and hygrometric behaviour. Hemp is also an eco-friendly and economical plant-based raw material for the construction industry.
An authentic assessment model to assess kindergarten students' character
Authors: Faizah Umi , Zuchdi Darmiyati , Alsamiri Yasir 
Published: July 2020

The aim of character development is essential to know, especially for kindergarten pupils. It might help teachers in developing students and offering helps and services. Thus, an assessment model is needed to identify children's character development easily and accurately. This study aims to (1) develop an assessment model for evaluating kindergarten pupils’ character which is considered valid, reliable, and fulfill the criteria of goodness of fit statistic, and (2) know the characteristics of an authentic assessment model instrument to assess the achievements of early childhood characters in kindergarten. This research used Plomp’s Research and Development Model. Data were collected using a questionnaire, documentation, interview, observation, and Focus Group Discussion. The validation was proven by the expert judgment with the Aiken’s V formula and the reliability was estimated with Cronbach’s Alpha. The validation construct and reliability were examined using Exploratory Factor Analysis, followed by Confirmatory Factor Analysis to ensure the result. Furthermore, the results of this research show that (1) the assessment model developed is ASOKA. This model is considered valid and reliable as it meets the criteria of goodness and fits the statistic; (2) the characteristics of an authentic assessment model instrument to assess the achievements of early childhood characters in kindergarten are: (a) with the index of Aiken's V analysis results of 0.901, the content validity is considered high; (b) the instrument construct validity has fulfilled the criteria of goodness of fit statistic; (c) as seen from Alpha Cronbach value coefficient 0.914, its instrument reliability is considered good enough.
Untold Stories in User-Centered Design of Mobile Health: Practical Challenges and Strategies Learned From the Design and Evaluation of an App for Older Adults With Heart Failure
Authors: Cornet Victor Philip , Toscos Tammy , Bolchini Davide , Rohani Ghahari Romisa , Ahmed Ryan , Daley Carly , Mirro Michael J , Holden Richard J 
Published: July 2020

Background
User-centered design (UCD) is a powerful framework for creating useful, easy-to-use, and satisfying mobile health (mHealth) apps. However, the literature seldom reports the practical challenges of implementing UCD, particularly in the field of mHealth.

Objective
This study aims to characterize the practical challenges encountered and propose strategies when implementing UCD for mHealth.

Methods
Our multidisciplinary team implemented a UCD process to design and evaluate a mobile app for older adults with heart failure. During and after this process, we documented the challenges the team encountered and the strategies they used or considered using to address those challenges.

Results
We identified 12 challenges, 3 about UCD as a whole and 9 across the UCD stages of formative research, design, and evaluation. Challenges included the timing of stakeholder involvement, overcoming designers’ assumptions, adapting methods to end users, and managing heterogeneity among stakeholders. To address these challenges, practical recommendations are provided to UCD researchers and practitioners.

Conclusions
UCD is a gold standard approach that is increasingly adopted for mHealth projects. Although UCD methods are well-described and easily accessible, practical challenges and strategies for implementing them are underreported. To improve the implementation of UCD for mHealth, we must tell and learn from these traditionally untold stories.
Exploring Suicidal Ideation Using an Innovative Mobile App-Strength Within Me: The Usability and Acceptability of Setting up a Trial Involving Mobile Technology and Mental Health Service Users
Authors: Bruen Ashley Jane , Wall Abbie , Haines-Delmont Alina , Perkins Elizabeth 
Published: July 2020

Background
Suicide is a growing global public health problem that has resulted in an increase in the demand for psychological services to address mental health issues. It is expected that 1 in 6 people on a waiting list for mental health services will attempt suicide. Although suicidal ideation has been shown to be linked to a higher risk of death by suicide, not everybody openly discloses their suicidal thoughts or plans to friends and family or seeks professional help before suicide. Therefore, new methods are needed to track suicide risk in real time together with a better understanding of the ways in which people communicate or express their suicidality. Considering the dynamic nature and challenges in understanding suicide ideation and suicide risk, mobile apps could be better suited to prevent suicide as they have the ability to collect real-time data.

Objective
This study aims to report the practicalities and acceptability of setting up and trialing digital technologies within an inpatient mental health setting in the United Kingdom and highlight their implications for future studies.

Methods
Service users were recruited from 6 inpatient wards in the north west of England. Service users who were eligible to participate and provided consent were given an iPhone and Fitbit for 7 days and were asked to interact with a novel phone app, Strength Within Me (SWiM). Interaction with the app involved journaling (recording daily activities, how this made them feel, and rating their mood) and the option to create safety plans for emotions causing difficulties (identifying strategies that helped with these emotions). Participants also had the option to allow the study to access their personal Facebook account to monitor their social media use and activity. In addition, clinical data (ie, assessments conducted by trained researchers targeting suicidality, depression, and sleep) were also collected.

Results
Overall, 43.0% (80/186 response rate) of eligible participants were recruited for the study. Of the total sample, 67 participants engaged in journaling, with the average number of entries per user being 8.2 (SD 8.7). Overall, only 24 participants created safety plans and the most common difficult emotion to be selected was feeling sad (n=21). This study reports on the engagement with the SWiM app, the technical difficulties the research team faced, the importance of building key relationships, and the implications of using Facebook as a source to detect suicidality.

Conclusions
To develop interventions that can be delivered in a timely manner, prediction of suicidality must be given priority. This paper has raised important issues and highlighted lessons learned from implementing a novel mobile app to detect the risk of suicidality for service users in an inpatient setting.
Diagnostic Value of Imaging Modalities for COVID-19: Scoping Review
Authors: Aljondi Rowa , Alghamdi Salem 
Published: July 2020

Background
Coronavirus disease (COVID-19) is a serious infectious disease that causes severe respiratory illness. This pandemic represents a serious public health risk. Therefore, early and accurate diagnosis is essential to control disease progression. Radiological examination plays a crucial role in the early identification and management of infected patients.

Objective
The aim of this review was to identify the diagnostic value of different imaging modalities used for diagnosis of COVID-19.

Methods
A comprehensive literature search was conducted using the PubMed, Scopus, Web of Science, and Google Scholar databases. The keywords diagnostic imaging, radiology, respiratory infection, pneumonia, coronavirus infection and COVID-19 were used to identify radiology articles focusing on the diagnosis of COVID-19 and to determine the diagnostic value of various imaging modalities, including x-ray, computed tomography (CT), ultrasound, and nuclear medicine for identification and management of infected patients.

Results
We identified 50 articles in the literature search. Studies that investigated the diagnostic roles and imaging features of patients with COVID-19, using either chest CT, lung ultrasound, chest x-ray, or positron emission topography/computed tomography (PET/CT) scan, were discussed. Of these imaging modalities, chest x-ray and CT scan are the most commonly used for diagnosis and management of COVID-19 patients, with chest CT scan being more accurate and sensitive in identifying COVID-19 at early stages. Only a few studies have investigated the roles of ultrasound and PET/CT scan in diagnosing COVID-19.

Conclusions
Chest CT scan remains the most sensitive imaging modality in initial diagnosis and management of suspected and confirmed patients with COVID-19. Other diagnostic imaging modalities could add value in evaluating disease progression and monitoring critically ill patients with COVID-19.
Utilization and Outcomes of Single and Dual Kidney Transplants from Older Deceased Donors in the United Kingdom
Authors: Ibrahim Maria , Greenhall George H.B. , Summers Dominic M. , Mumford Lisa , Johnson Rachel , Baker Richard J. , Forsythe John , Pettigrew Gavin J. , Ahmad Niaz , Callaghan Chris J. 
Published: July 2020

Background and objectives
Kidneys from elderly deceased donors are often discarded after procurement if the expected outcomes from single kidney transplantation are considered unacceptable. An alternative is to consider them for dual kidney transplantation. We aimed to examine the utilization of kidneys from donors aged ≥60 years in the United Kingdom and compare clinical outcomes of dual versus single kidney transplant recipients.

Design, setting, participants, & measurements
Data from the United Kingdom Transplant Registry from 2005 to 2017 were analyzed. We examined utilization rates of kidneys retrieved from deceased donors aged ≥60 years, and 5-year patient and death-censored graft survival of recipients of dual and single kidney transplants. Secondary outcomes included eGFR. Multivariable analyses and propensity score analysis were used to correct for differences between the groups.

Results
During the study period, 7841 kidneys were procured from deceased donors aged ≥60 years, of which 1338 (17%) were discarded; 356 dual and 5032 single kidneys were transplanted. Donors of dual transplants were older (median, 73 versus 66 years; P<0.001) and had higher United States Kidney Donor Risk Indices (2.48 versus 1.98; P<0.001). Recipients of dual transplants were also older (64 versus 61 years; P<0.001) and had less favorable human leukocyte antigen matching (P<0.001). After adjusting for confounders, dual and single transplants had similar 5-year graft survival (hazard ratio, 0.81; 95% CI, 0.59 to 1.12). No difference in patient survival was demonstrated. Similar findings were observed in a matched cohort with a propensity score analysis method. Median 12-month eGFR was significantly higher in the dual kidney transplant group (40 versus 36 ml/min per 1.73 m2; P<0.001).

Conclusions
Recipients of kidneys from donors aged ≥60 years have similar 5-year graft survival and better graft function at 12 months with dual compared with single deceased donor kidney transplants.
Empowering students’ critical thinking skills, information literacy and cognitive learning outcome through RBL-TPS model
Authors: Narahaubun Siti S. , Rehena Johanis F. , Rumahlatu Dominggus 
Published: July 2020

The use of proper learning model by teachers’ in a class room is crucial to be done in addressing the better learning quality. This study aimed at improving learning quality by choosing the most optimum learning model. This research was a quasi-experimental study using nonequivalent pretest-posttest control group design. This study was conducted in Senior High School 9 and Senior High School 5 of Ambon in academic year 2018/2019.The total sample used in this research was 127 students. The Critical Thingking Skills (CTS) and Cognitive Learning Outcome (CLO) tests as well as information literacy observation sheets were used as the instruments to gain the data. The data obtained in terms of students’ CTS, CLO ang information literacy were analyzed using inferential statistics (ANCOVA and LSD tests). The results showed that there were significant differences among X graders’ CTS, CLO, and information literacy [F(1,124) = 64.380, F(1,124) = 68.238 F(1,124) = 26.078 , p < 0.05] respectively, who were taught using RBL-TPS learning model in biodiversity material. In the other words, the RBL-TPS learning model is able to empower students’ CTS, CLO, and information literacy compared to the common learning model used by biology teachers. Thus, the used of RBL-TPS is recommended to be implemented in the other biology learning materials.