bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrolytes supplementation can decrease the risk of nephrotoxicity in patients with solid tumors undergoing chemotherapy with cisplatin
Authors: Minzi Omary M. S. , Lyimo Tatu E. , Furia Francis F. , Marealle Alphonce I. , Kilonzi Manase , Bwire George M. , Malichewe Christina 
Published: September 2020

Abstract
Background
Cisplatin is an important drug in the treatment of various Cancers. However, this drug causes nephrotoxicity that is linked to electrolyte derangement. The aim of this study was to evaluate the effect of electrolyte supplementation in reducing kidney injury in patients receiving cisplatin-based regimen.

Methods
This was non-randomized interventional study conducted at Ocean Road Cancer Institute (ORCI) among patients with confirmed solid tumors. Patients who received cisplatin-based chemotherapy at a dose of ≥50 mg with intravenous normal saline supplemented with Magnesium, Calcium and Potassium (triple electrolyte supplementation) were compared with those who received cisplatin-based chemotherapy with normal saline alone. The patients were followed up for 4 weeks and serum creatinine was measured at every visit. Nephrotoxicity was defined as serum creatinine elevation > 1.5 times that at baseline.

Results
A total of 99 patients were recruited, whereby 49 patients (49.5%) received electrolyte supplementation (treatment group) and 50 patients (51.5%) did not receive electrolyte supplementation (control group). The incidence risk of nephrotoxicity was 20.41% (n = 10) in the treatment group and 54% (n = 27) in the control group. Patients in the control group were 2.6 times more likely to experience nephrotoxicity as compared to treatment group [Relative Risks (RR); 2.6, 95%CI; 1.5–4.9, P < 0.0001]. The most common malignancy was cervical cancer, n = 43 (87.8%) in treatment group and n = 45 (90.0%) in the control group (P = 0.590). The Kaplan-Meier analysis and the log-rank test revealed that electrolytes supplementation was associated with extended survival with less nephrotoxicity incidences [P = 0.0004; Hazard ratio (HR) 0.3149; 95% CI 0.165 to 0.6011].

Conclusions
Electrolytes supplementation decreases the risk of nephrotoxicity after chemotherapy with cisplatin. A randomized controlled trial with a larger sample size is recommended to evaluate the robustness of these findings.
Staffordshire Bull Terriers in the UK: their disorder predispositions and protections
Authors: Pegram Camilla , Wonham Katie , Brodbelt Dave C. , Church David B. , O’Neill Dan G. 
Published: September 2020

AbstractBackgroundThe Staffordshire Bull Terrier is a popular dog breed in the UK but there is limited reliable evidence on disorder predispositions and protections within the breed. Using anonymised veterinary clinical data from the VetCompass™ Programme, this study aimed to identify common disorders with predisposition and protection in the Staffordshire Bull Terrier. The study hypothesised that Staffordshire Bull Terriers would have higher odds of aggression compared with non-Staffordshire Bull Terriers.ResultsThe clinical records of a random sample of dogs of all types were reviewed to extract the most definitive diagnoses for all disorders existing during 2016. A combined list from the 30 most common disorders in Staffordshire Bull Terriers and the 30 most common disorders in non-Staffordshire Bull Terriers was generated. Multivariable logistic regression was used to report the odds of each of these disorders in 1304 (5.8%) Staffordshire Bull Terriers compared with 21,029 (94.2%) non-Staffordshire Bull Terriers. After accounting for confounding, Staffordshire Bull Terriers had significantly increased odds of 4/36 (11.1%) disorders compared to non-Staffordshire Bull Terriers with highest odds for seizure disorder (OR 2.06; 95% CI 1.24 to 3.40;p = 0.005). Conversely, Staffordshire Bull Terriers had reduced odds of 5/36 (13.9%) disorders, with lowest odds for patellar luxation (OR 0.15; 95% CI 0.04 to 0.61;p = 0.008). There was no significant difference in the odds of aggression between Staffordshire Bull Terriers compared with non-Staffordshire Bull Terriers (OR 1.09; 95% CI 0.75 to 1.58;p = 0.644).ConclusionsThis study provides a reliable evidence base of breed-specific disorder predispositions and protections that can be used by breeders to optimise breeding decisions. The findings can assist prospective owners of Staffordshire Bull Terriers to make informed decisions when acquiring a dog. From the relative number of predispositions to protections identified, there is no evidence that Staffordshire Bull Terriers have higher overall health problems than non-Staffordshire Bull Terriers.
Biogeophysical and biogeochemical impacts of land-use change simulated by MIROC-ES2L
Authors: Ito Akihiko , Hajima Tomohiro 
Published: September 2020

AbstractLand-use change is one of the focal processes in Earth system models because it has strong impacts on terrestrial biogeophysical and biogeochemical conditions. However, modeling land-use impacts is still challenging because of model complexity and uncertainty. This study examined the results of simulations of land-use change impacts by the Model for Interdisciplinary Research on Climate, Earth System version 2 for long-term simulations (MIROC-ES2L) conducted under the Land-Use Model Intercomparison Project protocol. In a historical experiment, the model reproduced biogeophysical impacts such as decreasing trends in land-surface net radiation and evapotranspiration by about 1970. Among biogeochemical impacts, the model captured the global decrease of vegetation and soil carbon stocks caused by extensive deforestation. By releasing ecosystem carbon stock to the atmosphere, land-use change shortened the mean residence time of terrestrial carbon and accelerated its turnover rate, especially in low latitudes. Future projections based on Shared Socioeconomic Pathways indicated substantial alteration of land conditions caused primarily by climatic change and secondarily by land-use change. Sensitivity experiments conducted by exchanging land-use data between different future projection baseline experiments showed that, at the global scale, the anticipated extent of land-use conversion would likely play a modest role in the future terrestrial radiation, water, and carbon budgets. Regional investigations revealed that future land use would exert a considerable influence on runoff and vegetation carbon stock. Further model refinement is required to improve its capability to analyze its complicated terrestrial linkages or nexus (e.g., food, bioenergy, and carbon sequestration) to climate-change impacts.
Towards integrated assessments of water risks in deglaciating mountain areas: water scarcity and GLOF risk in the Peruvian Andes
Authors: Motschmann Alina , Huggel Christian , Muñoz Randy , Thür Angela 
Published: September 2020

AbstractDifferent water related risks such as lake outburst floods and water scarcity are typically assessed by separate methods and often by separate research communities. However, in a local context such as in mountain regions of the developing world different water risks are intertwined and shaped by multi-dimensional natural and socio-economic drivers. Progressing glacier melt and the associated growing number of lakes rises the threat of glacier lake outburst floods (GLOFs); at the same time declining melt water supply changes the hydrological regime, resulting in changing water availability, especially during dry seasons. Here, we address this challenge by integratively assessing water scarcity and GLOF risks and their interactions for two study sites in glacierized catchments in the Cordillera Blanca and Urubamba in the Peruvian Andes. We used hydrological modelling, GLOF flow path modelling, and interviews with local people and technical experts to assess the hazard and risks of water scarcity and GLOFs. We incorporate perspectives of people living in those areas in order to gain a more comprehensive view on risks. While metrics of flood and water scarcity hazards are difficult to compare, we found insightful results using a comparative analysis of elements at risk from different water related hazards with different probabilities of occurrence. Furthermore, our study shows that considering the diverse local perspectives on risks as well as the social, cultural, economic and political context is essential to more successful and sustainable disaster risk reduction, climate change adaptation and integrated water management.
The feasibility of an innovative GP-physiotherapist partnership to identify and manage chronic obstructive pulmonary disease (INTEGRATED): study protocol
Authors: Pagano Lisa , McKeough Zoe , Wootton Sally , Crone Stephen , Pallavicini Deborah , Chan Andrew S. L. , Mahadev Sriram , Zwar Nicholas , Dennis Sarah 
Published: September 2020

Abstract
Background
Chronic obstructive pulmonary disease (COPD) contributes significantly to mortality, hospitalisations and health care costs worldwide. There is evidence that the detection, accurate diagnosis and management of COPD are currently suboptimal in primary care. Physiotherapists are well-trained in cardiorespiratory management and chronic care but are currently underutilised in primary care. A cardiorespiratory physiotherapist working in partnership with general practitioners (GPs) has the potential to improve quality of care for people with COPD.

Methods
A prospective pilot study will test the feasibility of an integrated model of care between GPs and physiotherapists to improve the diagnosis and management of people with COPD in primary care. Four general practices will be selected to work in partnership with four physiotherapists from their local health district. Patients at risk of developing COPD or those with a current diagnosis of COPD will be invited to attend a baseline assessment with the physiotherapist, including pre- and post-bronchodilator spirometry to identify new cases of COPD or confirm a current diagnosis and stage of COPD. The intervention for those with COPD will involve the physiotherapist and GP working in partnership to develop and implement a care plan involving the following tailored to patient need: referral to pulmonary rehabilitation (PR), physical activity counselling, medication review, smoking cessation, review of inhaler technique and education. Process outcomes will include the number of people invited and reviewed at the practice, the proportion with a new diagnosis of COPD, the number of patients eligible and referred to PR and the number who attended PR. Patient outcomes will include changes in symptoms, physical activity levels, smoking status and self-reported exacerbations.

Discussion
If feasible, we will test the integration of physiotherapists within the primary care setting in a cluster randomised controlled trial. If the model improves health outcomes for the growing numbers of people with COPD, then it may provide a GP-physiotherapist model of care that could be tested for other chronic conditions.

Trial registration
ANZCTR, ACTRN12619001127190. Registered on 12 August 2019—retrospectively registered.
Design, rationale and analysis plan for the Stand Up for Health trial in contact centres: a stepped wedge feasibility study
Authors: Parker Richard A. , Manner Jillian , Sivaramakrishnan Divya , Baker Graham , Stoddart Andrew , Lloyd Scott , Jepson Ruth 
Published: September 2020

Abstract
Background
Contact centres are one of the most sedentary workplaces, with employees spending a very high proportion of their working day sitting down. About a quarter of contact centre staff regularly experience musculoskeletal health problems due to high levels of sedentary behaviour, including lower back pain. There have been no previous randomised studies specifically aiming to reduce sedentary behaviour in contact centre staff. To address this gap, the Stand Up for Health (SUH) study aims to test the feasibility and acceptability of a complex theory-based intervention to reduce sedentary behaviour in contact centres.

Methods
The Stand Up for Health study has a stepped wedge cluster randomised trial design, which is a pragmatic design whereby clusters (contact centres) are randomised to time points at which they will begin to receive the intervention. All contact centre staff have the opportunity to experience the intervention. To minimise the resource burden in this feasibility study, data collection is not continuous, but undertaken on a selective number of occasions, so the stepped wedge design is “incomplete”. Eleven contact centres in England and Scotland have been recruited, and the sample size is approximately 27 per centre (270 in total). The statistical analysis will predominantly focus on assessing feasibility, including the calculation of recruitment rates and rates of attrition. Exploratory analysis will be performed to compare objectively measured sedentary time in the workplace (measured using an activPAL™ device) between intervention and control conditions using a linear mixed effects regression model.

Discussion
To our knowledge, this is the first stepped wedge feasibility study conducted in call centres. The rationale and justification of our novel staircase stepped wedge design has been presented, and we hope that by presenting our study design and statistical analysis plan, it will contribute to the literature on stepped wedge trials, and in particular feasibility stepped wedge trials. The findings of the study will also help inform whether this is a suitable design for other settings where data collection is challenging.

Trial registration
The trial has been registered on the ISRCTN database: http://www.isrctn.com/ISRCTN11580369
Prevalence of HIV-associated esophageal candidiasis in sub-Saharan Africa: a systematic review and meta-analysis
Authors: Olum Ronald , Baluku Joseph Baruch , Okidi Ronald , Andia-Biraro Irene , Bongomin Felix 
Published: September 2020

Abstract
Background
Esophageal candidiasis (OC) is a common AIDS-defining opportunistic infection. Antiretroviral therapy (ART) reduces the occurrence of OC and other opportunistic infections among persons living with HIV (PLHIV). We sought to determine and compare the prevalence of OC in the ART and pre-ART era among PLHIV in sub-Saharan Africa (SSA).

Methods
We searched PubMed, Embase, Web of Science, and the African Journals Online databases to select studies in English and French reporting the prevalence of HIV-associated OC in SSA from January 1980 to June 2020. Reviews, single-case reports, and case series reporting < 10 patients were excluded. A random-effect cumulative meta-analysis was performed using STATA 16.0, and trend analysis performed using GraphPad Prism 8.0.

Results
Thirteen eligible studies from 9 SSA countries including a total of 113,272 patients were qualitatively synthesized, and 9 studies were included in the meta-analysis. Overall pooled prevalence of HIV-associated OC was 12% (95% confidence interval (CI): 8 to 15%, I2 = 98.61%, p <. 001). The prevalence was higher in the pre-ART era compared to the ART era, but not to statistical significance (34.1% vs. 8.7%, p = 0.095). In those diagnosed by endoscopy, the prevalence was higher compared to patients diagnosed by non-endoscopic approaches, but not to statistical significance (35.1% vs. 8.4%, p = .071). The prevalence of OC significantly decreased over the study period (24 to 16%, p < .025).

Conclusion
The prevalence of OC among PLHIV in the ART era in SSA is decreasing. However, OC remains a common problem. Active endoscopic surveillance of symptomatic patients and further empirical studies into the microbiology, optimal antifungal treatment, and impact of OC on quality of life of PLHIV in SSA are recommended.
Clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: adult cardiac conditions
Authors: Ali Arafat , Ballard David H. , Althobaity Waleed , Christensen Andy , Geritano Mariah , Ho Michelle , Liacouras Peter , Matsumoto Jane , Morris Jonathan , Ryan Justin , Shorti Rami , Wake Nicole , Rybicki Frank J. , Sheikh Adnan ,   on behalf of the RSNA 3D Printing Special Interest Group
Published: September 2020

Abstract
Background
Medical 3D printing as a component of care for adults with cardiovascular diseases has expanded dramatically. A writing group composed of the Radiological Society of North America (RSNA) Special Interest Group on 3D Printing (SIG) provides appropriateness criteria for adult cardiac 3D printing indications.

Methods
A structured literature search was conducted to identify all relevant articles using 3D printing technology associated with a number of adult cardiac indications, physiologic, and pathologic processes. Each study was vetted by the authors and graded according to published guidelines.

Results
Evidence-based appropriateness guidelines are provided for the following areas in adult cardiac care; cardiac fundamentals, perioperative and intraoperative care, coronary disease and ischemic heart disease, complications of myocardial infarction, valve disease, cardiac arrhythmias, cardiac neoplasm, cardiac transplant and mechanical circulatory support, heart failure, preventative cardiology, cardiac and pericardial disease and cardiac trauma.

Conclusions
Adoption of common clinical standards regarding appropriate use, information and material management, and quality control are needed to ensure the greatest possible clinical benefit from 3D printing. This consensus guideline document, created by the members of the RSNA 3D printing Special Interest Group, will provide a reference for clinical standards of 3D printing for adult cardiac indications.
Diagnostic efficacy of gel infusion sonography in post-menopausal bleeding
Authors: Ahmed Shimaa Abdalla , Abo-Taleb Hisham 
Published: September 2020

Abstract
Background
Our purpose was to evaluate the diagnostic performance of two-dimensional transvaginal ultrasound (2D-TVUS) and gel infusion sonography (GIS) at offline analysis for endometrial characterization compared with real-time evaluation during scanning.
One hundred fifty women presented with PMB. At TVUS, endometrial thickness was ≥ 4 mm in 122 (81.3%) women and < 4 mm in 28 (18.72%). Among 122 women with endometrial thickness > 4 mm, GIS was successfully performed in 117 (95.9%). Examinations were stored as video clips for later evaluation (offline analysis) by two less experienced radiologists. Endometrial lesions were classified into four categories: no endometrial abnormality, hyperplasia, polyps, and cancer. Diagnostic efficiency of real-time and offline analysis for diagnosis of each category was calculated and compared, and inter-observer agreement for offline analysis was calculated.

Results
All patients underwent hysteroscopy and/or hysterectomy. Histopathological results confirmed no endometrial abnormality in (27.3%, 41/150), endometrial hyperplasia in (12.7%, 19/150), endometrial polyps in (17.3%, 26/150), and endometrial cancer in (42.7%, 64/150).
Overall diagnostic accuracy of real-time imaging was 89.7% (CI 84–91%)). The highest accuracy 92.7% (CI 88–98%) was seen in the diagnosis of cancer, and polyps 91.5% (CI 86–97%). The lowest accuracy 75% (CI 69–82%) was seen in hyperplasia.
Overall diagnostic accuracy of offline analysis was 81%, and it increased to 88% (CI 83–92%) after a restricted analysis of good quality clips. The highest accuracy 90.7% (CI 83–95%) was seen in the diagnosis of polyps, and cancer 90.4% (CI 83–96%). The lowest accuracy 71% (CI 69–75%) was seen in hyperplasia.
At offline analysis, the inter-observer agreement was substantial k = 0.77 (CI 71–84) in the evaluation of four endometrial categories after the exclusion of bad quality videos. It was excellent in exclusion of endometrial abnormalities k = 0.85 (0.78–0.90), substantial in the diagnosis of polyps k = 0.71 (0.69–0.88), cancer k = 0.61 (0.61–0.77), and moderate in the diagnosis of hyperplasia k = 0.41 (0.30–0.41).

Conclusion
Offline 2D analysis with a good image quality has comparable accuracy to a real-time evaluation during scanning in the diagnosis of endometrial lesions. It can increase the accuracy of sonography in ruling out endometrial abnormalities and diagnose non-hyperplastic endometrial pathologies. High NPV and substantial reproducibility can make it an efficient initial screening method in a post-menopausal bleeding.
More than noise: Context-dependant luminance contrast discrimination in a coral reef fish (Rhinecanthus aculeatus)
Authors: van den Berg Cedric P. , Hollenkamp Michelle , Mitchell Laurie J. , Watson Erin J. , Green Naomi F. , Marshall N. Justin , Cheney Karen L. 
Published: September 2020

Achromatic (luminance) vision is used by animals to perceive motion, pattern, space and texture. Luminance contrast sensitivity thresholds are often poorly characterised for individual species and are applied across a diverse range of perceptual contexts using over-simplified assumptions of an animal's visual system. Such thresholds are often estimated using the Receptor Noise Limited model (RNL) using quantum catch values and estimated noise levels of photoreceptors. However, the suitability of the RNL model to describe luminance contrast perception remains poorly tested.
Here, we investigated context-dependent luminance discrimination using triggerfish (Rhinecanthus aculeatus) presented with large achromatic stimuli (spots) against uniform achromatic backgrounds of varying absolute and relative contrasts. ‘Dark’ and ‘bright’ spots were presented against relatively dark and bright backgrounds. We found significant differences in luminance discrimination thresholds across treatments. When measured using Michelson contrast, thresholds for bright spots on a bright background were significantly higher than for other scenarios, and the lowest threshold was found when dark spots were presented on dark backgrounds. Thresholds expressed in Weber contrast revealed increased contrast sensitivity for stimuli darker than their backgrounds, which is consistent with the literature. The RNL model was unable to estimate threshold scaling across scenarios as predicted by the Weber-Fechner law, highlighting limitations in the current use of the RNL model to quantify luminance contrast perception. Our study confirms that luminance contrast discrimination thresholds are context-dependent and should therefore be interpreted with caution.
O cuidado ao idoso com transtorno mental em uma instituição de longa permanência no Sudoeste de Minas Gerais: relatos de cuidadores e equipe de enfermagem
Authors: Martins Graziele Alves , Gomes Lilian Cristiane 
Published: September 2020

Objetivo: identificar o cuidado ao idoso institucionalizado com transtorno mental, as principais dificuldades e percepções da equipe diante do cuidado e de seu impacto na relação profissional-paciente. Métodos: estudo transversal e descritivo, de abordagem qualitativa. A amostra foi constituída de oito profissionais, entre membros da equipe de enfermagem e cuidadores de idosos, em uma instituição de longa permanência para idosos de um município do sudoeste mineiro. A coleta de dados foi realizada na própria instituição, por meio de gravação das verbalizações (depoimentos) dos participantes, mediante roteiro padronizado de entrevista individual, contendo variáveis sociodemográficas e profissionais para a caracterização da amostra, bem como três questões disparadoras concernentes ao objetivo do estudo. Para a interpretação dos dados, utilizou-se a técnica da análise temática de conteúdo. Resultados: entre os entrevistados, houve predomínio de profissionais do sexo feminino, com nível médio de escolaridade e curto tempo de formação e de atuação em instituições de longa permanência para idosos. Ao investigar o cuidado ao idoso com transtorno mental, evidenciaram-se duas categorias temáticas: lidando com as reações de agressividade do idoso e seu impacto no cuidado; despreparo/ insegurança do profissional e a falta de recursos. Conclusão: os achados reiteram a necessidade de capacitação de recursos humanos na área de Gerontologia, com ênfase em Saúde Mental, assim como a atuação de uma equipe multidisciplinar junto aos idosos institucionalizados.