bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sedimentary Facies, Provenance and Geochronology of the Heshangzhen Group: Implications for the Tectonic Evolution of the Eastern Jiangnan Orogen, South China
Authors: ZHOU Xiaohua , HU Xiumian , JIANG Ren , GAO Tianshan , MA Xue , XING Guangfu , SUN Gaoyuan , SHU Xujie , ZHAO Xilin 
Published: August 2020

AbstractThe Neoproterozoic Jiangnan orogen plays an important role in the study of the Precambrian tectonic evolution of South China. The tectonic nature of the Neoproterozoic sedimentary basins is still controversial, due to poor understanding of the sedimentary sequences and the lack of geochronological data. Here, we present sedimentological, provenance and geochronological data from the Heshangzhen Group in the eastern Jiangnan orogen. Sedimentological analysis shows that the Luojiamen Formation was deposited in a submarine fan, and the overlying Hongchicun Formation was deposited in front of a fan delta. The youngest detrital zircons constrain the lower Luojiamen and Hongchicun formations with ages of 827.3 ± 8.4 Ma and 825 ± 12 Ma, respectively. The sandstones of the Luojiamen Formation are characterized by a large number of intermediate to felsic volcanic grains, suggesting a volcanic arc source. In contrast, quartz and sedimentary lithic grains increase in the Hongchicun Formation, showing a new input from a collisional orogenic source. Detrital zircon from six sandstone samples in the Luojiamen and Hongchicun formations yield similar age spectra of 930–820 Ma with a peak at ca. 845–860 Ma, with one main cluster at 930–820 Ma. Detrital zircons of 930–845 Ma show a positive value of∊Hf(t) (+2.4 to +11, mean +7.6), which is similar to the volcanic arc of the nearby Shuangxiwu Group. There are a minor group of zircons with U‐Pb ages ranging from 820 Ma to 845 Ma from the middle part of the Luojiamen Formation and Hongchicun Formation, with ∊Hf(t) values between –20 to +2.4, which are consistent with the characteristics of the Shuangqiaoshan Group. within light of the bidirectional paleocurrents in the Luojiamen Formation, it is speculated that the zircons of 820–845 Ma were recycled from the Shuangqiaoshan Group, which is derived from a continental arc to the northwest. Our data suggests that the Luojiamen Formation was formed in an inter‐arc basin, while the Hongchicun Formation was formed in an accretionary wedge‐top basin. When juxtaposed with the conglomeratic characteristics at the bottom of the Luojiamen Formation, it is believed that the unconformity represented by the ‘Shen Gong Movement’ reflects the rapid erosion and accumulation process of island arc volcanic material. The disconformity between the Luojiamen and Hongchicun formations is the imprint of transition from inter‐arc basin to accretionary wedge‐top basin, which represents the collision between the Shuangxiwu arc and the Yangtze Plate.
Increased frequency of sleep problems in children and adolescents with familial Mediterranean fever: The role of anxiety and depression
Authors: Durcan Gizem , Yildiz Mehmet , Kadak Muhammed Tayyib , Barut Kenan , Kavruk Erdim Nese , Sahin Sezgin , Adrovic Amra , Haslak Fatih , Dogangun Burak , Kasapcopur Ozgur 
Published: August 2020

AbstractAimFamilial Mediterranean fever (FMF) is the most common hereditary autoinflammatory disease. The main goal of our study is to compare sleep habits, depression and anxiety of patients with FMF to healthy children and to determine the influence of disease‐related factors on sleep habits and psychiatric symptoms.MethodIn total, 323 child and adolescent patients with FMF and 260 healthy peers as a control group were included in this study. Questionnaires were used to evaluate sleep habits, psychological status of children and adolescents with and without FMF.ResultsWhile there was not a significant difference in terms of age, gender, depression and anxiety scores (P > 0.05); patients with FMF had significantly higher total sleeping score (45.69 ± 7.70 vs 43.31 ± 7.77; P = 0.001). Depression and anxiety scores of patients with FMF who have been experiencing sleep problems were found to be dramatically higher compared to those FMF patients without sleep problems (7.70 ± 5.56 vs 4.59 ± 3.97; P = 0.001; 35.46 ± 18.57 vs 25.22 ± 14.12; P = 0.001; respectively). Patients with FMF who had a disease attack last month had remarkably higher depression, anxiety and sleeping scores compared to those who did not. When FMF patients were compared in terms of exertional leg pain, increased acute phase reactant levels, comorbidity and mutation types, there was not a significant difference for depression, anxiety and sleeping scores.ConclusionChildren and adolescents with FMF experience more sleeping problems compared to healthy children and in presence of sleeping disorders, psychiatric symptoms are seen more frequently. Therefore, evaluation of psychopathology is important if youth with FMF have sleep problems.
blaOXA‐731, a new chromosome‐encoded blaOXA‐48‐like variant in Shewanella sp. from the aquatic environment in Myanmar
Authors: Shanmugakani Rathina Kumar , Sugawara Yo , Akeda Yukihiro , Hagiya Hideharu , Sakamoto Noriko , Aye Mya Mya , Myint Thuzar , Hamada Shigeyuki , Tomono Kazunori 
Published: August 2020

SummaryShewanella sp., the progenitors of blaOXA‐48‐like genes are increasingly reported with the possession of different blaOXA‐48‐like variants. This study aims to characterize blaOXA‐731, a new variant of a blaOXA‐48‐like gene identified in Shewanella sp. isolated from the aquatic environment in Myanmar. Phylogenetic analysis of the blaOXA‐731 sequence with other blaOXA‐48‐like variants showed that it has the highest nucleotide identity of 86.09% with blaOXA‐48. However, the active site motifs in OXA‐731 were 100% identical to that in OXA‐48. Whole‐genome sequencing analysis showed that blaOXA‐731 is not surrounded by any mobile genetic elements. The genetic context of blaOXA‐731 was found as similar to other blaOXA‐48‐like genes previously identified in Shewanella sp. S1 nuclease pulsed‐field gel electrophoresis followed by Southern blotting confirmed the location of blaOXA‐731 in the chromosome of the Shewanella genome. Cloning and expression studies showed that OXA‐731 has β‐lactamase activity similar to OXA‐48 and OXA‐181, but it has no significant carbapenemase activity. Our results showed the significance of blaOXA‐48‐like‐carrying Shewanella sp. in the spreading of blaOXA‐48‐like genes in the community.
Measuring the Economic Risk of COVID‐19
Authors: Noy Ilan , Doan Nguyen , Ferrarini Benno , Park Donghyun 
Published: August 2020

AbstractWe measure the economic risk of COVID‐19 at a geo‐spatially detailed resolution. In addition to data about the current prevalence of confirmed cases, we use data from 2014–2018 and a conceptual disaster risk model to compute measures for exposure, vulnerability, and resilience of the local economy to the shock of the epidemic. Using a battery of proxies for these four concepts, we calculate the hazard, the principal components of exposure and vulnerability to it, and of the economy’s resilience (i.e. its ability of the recover rapidly from the shock). We find that the economic risk of this pandemic is particularly high in most of Sub‐Saharan Africa, South Asia, and Southeast Asia. These results are consistent when comparing an ad hoc equal weighting algorithm for the four components of the index, an algorithm that assumes equal hazard for all countries, and one based on estimated weights using previous aggregated disability‐adjusted life years losses associated with communicable diseases.
Bidirectional sex‐dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε
Authors: Moen Janna K. , DeBaker Margot C. , Myjak Julia E. , Wickman Kevin , Lee Anna M. 
Published: August 2020

AbstractNicotine and alcohol are the most commonly abused substances worldwide and are frequently coabused. Nicotinic acetylcholine receptors (nAChRs) containing the α6 and β3 subunits are expressed in neural reward circuits and are critical for nicotine and alcohol reward. nAChRs are dynamically regulated by signaling molecules such as protein kinase C epsilon (PKCε), which impact transcription of α6 and β3 subunit mRNA (Chrna6 and Chrnb3, respectively). Previous work found decreased expression of Chrna6 and Chrnb3 transcripts in the ventral midbrain of male PKCε−/− mice, who also consume less nicotine and alcohol compared with wild‐type (WT) littermates. Using RT‐qPCR, we show that female PKCε−/− mice have higher expression of Chrna6 and Chrnb3 transcripts in the ventral midbrain, which functionally impacts nAChR‐dependent behavior as female but not male PKCε−/− mice exhibit locomotor hypersensitivity to low‐dose (0.25 mg/kg i.p.) nicotine. Female PKCε−/− mice show no differences in alcohol‐induced sedation in the loss‐of‐righting reflex assay (4.0 g/kg i.p.) compared with WT littermates, whereas male PKCε−/− mice have enhanced sedation compared with WT mice. Female PKCε−/− mice also show reduced immobility time in response to varenicline (1.0 mg/kg i.p.) compared with WT littermates in the tail suspension test, and this effect was absent in male mice. Additionally, we found that female PKCε−/− mice show altered alcohol and nicotine consumption patterns in chronic voluntary two‐bottle choice assays. Our data reveal a bidirectional effect of sex in the transcriptional regulation of nicotinic receptors by PKCε, highlighting the importance of studying both sexes in preclinical animal models.
Living in the shadows: Diversity of amphibians, reptiles and birds in shade‐grown yerba mate (Ilex paraguariensis) plantations
Authors: Cabral Hugo , Coronel‐Bejarano Diana , Ruiz Rodolfo , Cañete Lucas , Britez Evelyn , Rojas Viviana 
Published: August 2020

AbstractNativeIlex paraguariensis(yerba mate) is one of the most widespread crops in the Atlantic Forest region of southern South America and has an important economic and cultural value in Paraguay, Argentina, Brazil and Uruguay. Despite the known potential of shade‐grown products (especially cocoa and coffee) to protect biodiversity, the benefits of shade‐grown yerba mate for biodiversity conservation in the Atlantic Forest remain scarce, one of the most threatened ecoregions in the world, also considered a biodiversity hotspot. In order to understand these potential benefits, it is important to identify how species use shade‐grown yerba mate plantations, as well as if it can be an strategy to improve or maintain biodiversity in complex socio‐ecological landscapes. We analysed the potential benefits of forests with shade‐grown yerba mate for birds, amphibian and reptiles in the Reserve for National Park ‘San Rafael’ and its buffer area (Itapúa Department, Paraguay). We evaluated differences in species richness and composition between three environments: forest with shade‐grown yerba mate, forest edge and monoculture crop plantations analysing beta diversity. A total of 112 bird species were recorded in all three environments. Regarding the herpetological community, we recorded 10 species (seven amphibians and three reptiles). Our results indicate that forests with yerba mate plantations not only maintains the bird species richness, but also its species composition differs significantly from edge and croplands, which might be an indicator of the contribution of shade‐grown yerba mate plantations to conservation. The results of the research would help to value the impact of sustainable agroforestry activities for the conservation of Atlantic Forest biodiversity.Abstract in Spanish is available with online material.
Evaluation of a culturally sensitive social and emotional well‐being program for Aboriginal and Torres Strait Islanders
Authors: Snodgrass William J. , Rayner Victoria , Rice Simon M. , Purcell Rosemary , Bowers Jennifer 
Published: August 2020

AbstractObjectiveTo evaluate Deadly Thinking, a social and emotional well‐being promotion program targeted to remote and rural Aboriginal and Torres Strait Islander communities. Deadly Thinking aims to improve emotional health literacy, psychological well‐being and attitudes towards associated help‐seeking.DesignParticipants completed pre/post‐test evaluations via a brief self‐report survey immediately before and after the Deadly Thinking workshop.SettingAboriginal and Torres Strait Islander communities in rural and regional Australia.ParticipantsData were obtained from 413 participants (69.8% female, mean age 41.6 years), of whom 70.4% identified as Aboriginal or Torres Strait Islanders.InterventionDeadly Thinking workshops involve participant's engaging with a series of videos and facilitated group discussions with other participants related to social and emotional well‐being topics relevant to individuals and communities.Main outcome measuresParticipants completed measures of psychological distress, suicidal ideation, substance use, changes in attitudes towards help‐seeking and help‐seeking intentions and satisfaction with the workshop. Additionally, participants in a train‐the‐trainer workshop rated their perceived confidence to deliver the program post‐workshop.ResultParticipants reported positive perceptions of community safety and well‐being and low rates of marked distress, with no significant difference between train‐the‐trainer and community workshop participants. Results indicated significant improvement in help‐seeking intentions post‐workshop and high rates of satisfaction with workshop components.ConclusionInitial evaluation indicates good acceptability and feasibility of delivering the Deadly Thinking program in rural and remote Indigenous communities; however, more robust evaluation of the program is warranted using controlled conditions to measure effectiveness, particularly for changing in help‐seeking behaviour.
Editorial: social distancing during the COVID‐19 pandemic – IBD patients cannot stay at home forever
Authors: Benson‐Pope Samantha Jane , Gearry Richard B. 
Published: August 2020

LINKED CONTENTThis article is linked to the Taxonera et al and Taxonera and Alba papers. To view these articles, visit https://doi.org/10.1111/apt.15804 and https://doi.org/10.1111/apt.15937
Editorial: acute non‐cirrhotic and non‐malignant portal vein thrombosis—who should be candidates for interventional treatment?
Authors: Zhang Dan , Xu Shixue , Tian Yulong , Qi Xingshun 
Published: August 2020

LINKED CONTENTThis article is linked to the Rössle et al papers. To view these articles, visit https://doi.org/10.1111/apt.15811 and https://doi.org/10.1111/apt.15930
Editorial: a diabetologist’s perspective on the diagnosis and monitoring of NAFLD—Authors' reply
Authors: Younossi Zobair M. , Henry Linda 
Published: August 2020

LINKED CONTENTThis article is linked to the Younossi et al and Targher et al papers. To view these articles, visit https://doi.org/10.1111/apt.15830 and https://doi.org/10.1111/apt.15906
Letter: the under‐treatment and under‐diagnosis of pancreatic exocrine insufficiency in chronic pancreatitis and pancreatic cancer is just the tip of the iceberg—authors' reply
Authors: Forsmark Chris E. , Yadav Dhiraj 
Published: August 2020

LINKED CONTENTThis article is linked to Forsmark et al and Shiha et al papers. To view these articles, visit https://doi.org/10.1111/apt.15698 and https://doi.org/10.1111/apt.15913
Thoracoscopic right middle lobectomy for Mycobacterium abscessus in a young patient suspected of having congenital immunodeficiency
Authors: Sekihara Keigo , Hirai Hoshie , Sumiya Ryusuke , Momose Naoya , Sugimura Aya , Nagasaka Satoshi 
Published: August 2020

AbstractMycobacterium abscessus (M. abscessus) infection is resistant to multi‐antibacterial treatment, and surgical resection is often recommended. We report a case of M. abscessus infection in a young patient suspected of having a GATA2 mutation. A 19‐year‐old woman with a medical history of severe sinusitis and a family history of non‐tuberculous mycobacteriosis presented at our hospital. M. abscessus was confirmed by sputum culture. The patient received multidrug therapy, including clarithromycin. CT scan demonstrated bronchodilation and capacity decrease due to non‐obstructive atelectasis in the middle lobe. We performed thoracoscopic resection without complications. Congenital immunodeficiency was suspected given the patient's past medical and family history. The result of lymphocyte subset analysis revealed a GATA2 mutation, but no genetic mutation was detected by a next‐generation sequencer. The patient followed a good clinical course. This paper reports the successful treatment of an M. abscessus infection and the importance of checking the genetic background of young patients.
Complex effect of continuous curcumin exposure on human bone marrow‐derived mesenchymal stem cell regenerative properties through matrix metalloproteinase regulation
Authors: Yang Qichen , Leong Samantha Antonio , Chan Kwok Ping , Yuan Xiang‐Ling , Ng Tsz Kin 
Published: August 2020

AbstractCurcumin has been reported to be beneficial for cancers, cardiovascular and neurodegenerative diseases, based on its anti‐oxidative, anti‐inflammation, anti‐tumorigenic and neuroprotective properties. With its high‐dose application, curcumin toxicity to systemic tissues is a reasonable concern. Here, we report the responses of human bone marrow‐derived mesenchymal stem cells (hBM‐MSCs) to continuous curcumin exposure. hBM‐MSCs were treated with 0.01‐100 μmol/L curcumin continuously in vitro for 7 days. 25 μmol/L curcumin or above significantly attenuated hBM‐MSC maintenance, whereas 10 μmol/L curcumin reduced hBM‐MSC proliferation and hindered their migration with increasing cell apoptosis. Besides, 5 μmol/L curcumin treatment inhibited hBM‐MSC adipogenic differentiation, but enhanced osteogenic differentiation, which depended on matrix metalloproteinase (MMP)‐13 expression and activity. Furthermore, curcumin treatment reduced MMP1 expression but up‐regulated the immunomodulatory gene IDO1 expression. In summary, this study revealed the complex effects of continuous curcumin exposure on hBM‐MSC maintenance and regenerative properties through MMP regulation. Given the complex effects of curcumin, its use for biomedical purposes should be carefully considered in treatment length and dosage.
Characterisation of centriole biogenesis during multiciliation in planarians
Authors: Li Yaping , Guo Fanghao , Jing Qing , Zhu Xueliang , Yan Xiumin 
Published: August 2020

Background InformationDense multicilia in protozoa and metazoa generate a strong force important for locomotion and extracellular fluid flow. During ciliogenesis, multiciliated cells produce hundreds of centrioles to serve as basal bodies through various pathways including deuterosome‐dependent (DD), hyper‐activated mother centriole‐dependent (MCD) and basal bodydependent (BBD) pathways. The centrosome‐free planarian Schmidtea mediterranea is widely used for regeneration studies because its neoblasts are capable of regenerating any body part after injury. However, it is currently unclear how the flatworms generate massive centrioles for multiciliated cells in the pharynx and body epidermis when their cells are initially centriole‐free.ResultsIn this study, we investigate the progress of centriole amplification during the pharynx regeneration. We observe that the planarian pharyngeal epithelial cells generate their centrioles asynchronously through a de novo pathway. Most of the de novo centrioles are formed individually, whereas the remaining ones are assembled in pairs, possibly by sharing a cartwheel, or in small clusters lacking a nucleation center. Further RNAi experiments show that the known key factors of centriole duplication, including Cep152, Plk4 and Sas6, are crucial for the centriole amplification.Conclusions and SignificanceOur study demonstrates the distinct process of massive centriole biogenesis in S. mediterranea and helps to understand the diversity of centriole biogenesis during evolution.
The hidden role of NLRP3 inflammasome in obesity‐related COVID‐19 exacerbations: Lessons for drug repurposing
Authors: Bertocchi Ilaria , Foglietta Federica , Collotta Debora , Eva Carola , Brancaleone Vincenzo , Thiemermann Christoph , Collino Massimo 
Published: August 2020

COVID‐19, the illness caused by SARS‐CoV‐2, has a wide‐ranging clinical spectrum that, in the worst‐case scenario, involves a rapid progression to severe acute respiratory syndrome and death. Epidemiological data show that obesity and diabetes are among the main risk factors associated with high morbidity and mortality. The increased susceptibility to SARS‐CoV‐2 infection documented in obesity‐related metabolic derangements argues for initial defects in defence mechanisms, most likely due to an elevated systemic metabolic inflammation (“metaflammation”). The NLRP3 inflammasome is a master regulator of metaflammation and has a pivotal role in the pathophysiology of either obesity or diabetes. Here, we discuss the most recent findings suggesting contribution of NLRP3 inflammasome to the increase in complications in COVID‐19 patients with diabesity. We also review current pharmacological strategies for COVID‐19, focusing on treatments whose efficacy could be due, at least in part, to interference with the activation of the NLRP3 inflammasome.Linked ArticlesThis article is part of a themed issue on The Pharmacology of COVID‐19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc
Psychometric properties of the Turkish version of Participation and Environment Measure for Children and Youth
Authors: Kaya Kara Ozgun , Turker Duygu , Kara Koray , Yardimci‐Lokmanoglu Bilge Nur 
Published: August 2020

AbstractBackgroundParticipation in daily activities provides many opportunities for children with and without disabilities to improve cognitive, physical and communication abilities; to develop social relationships and to promote adaptive behaviours. The aim of this study is to examine the psychometric properties of the Participation Environment Measure for Children and Youth (PEM‐CY) in Turkish children and youth with and without a disability.MethodsA total of 410 parents of children with (n = 232) and without (n = 178) disabilities, aged 5–17 years, were included in this study. Cronbach's alpha (α) and intraclass correlation coefficients (ICCs) were evaluated for internal consistency and test–retest reliability, respectively. Discriminant validity was determined by comparing the differences in participation and environment scores for disability groups and age intervals with the two‐way analysis of variance (ANOVA) followed by post‐hoc analyses when results were statistically significant.ResultsInternal consistency (0.67–0.80) and test–retest reliability (0.67–0.93, p < 0.0001) ranged from moderate to very strong for different summary scores. Discriminant validity of the Turkish version of PEM‐CY was supported by significant differences between children with and without disabilities on participation and environment scales (p < 0.05). We identified some significant age differences, but they did not follow consistently.ConclusionsThe Turkish version of the PEM‐CY is a valid and reliable tool to determine the participation and environmental factors in the home, at school and in community settings in Turkish children and youth aged 5–17 years, with and without disabilities.