bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agathisflavone, a Biflavonoid from Anacardium occidentale L., Inhibits Influenza Virus Neuraminidase
Authors: de Freitas Caroline S. , Rocha Marco E.N. , Sacramento Carolina Q. , Marttorelli Andressa , Ferreira André C. , Rocha Natasha , de Oliveira Andrea Cheble , de Oliveira Gomes Andre Marco , dos Santos Patrícia Souza , da Silva Edilene Oliveira , da Costa Josineide Pantoja , de Lima Moreira Davyson , Bozza Patrícia T. , Silva Jerson L. , Barroso Shana Priscila Coutinho , Souza Thiago Moreno L. 
Published: December 2019

Background:
Neuraminidase inhibitors (NAIs) are the only class of antivirals in clinical use
against influenza virus approved worldwide. However, approximately 1-3% of circulating strains present
resistance mutations to oseltamivir (OST), the most used NAI. Therefore, it is important to catalogue
new molecules to inhibit influenza virus, especially OST-resistant strains. Natural products from
tropical plants used for human consumption represent a worthy class of substances. Their use could be
stimulated in resource-limited setting where the access to expensive antiviral therapies is restricted.

Methods:
We evaluated the anti-influenza virus activity of agathisflavone derived from Anacardium
occidentale L.

Results:
The neuraminidase (NA) activity of wild-type and OST-resistant influenza virus was inhibited
by agathisflavone, with IC50 values ranging from 20 to 2.0 µM, respectively. Agathisflavone inhibited
influenza virus replication with EC50 of 1.3 µM. Sequential passages of the virus in the presence of
agathisflavone revealed the emergence of mutation R249S, A250S and R253Q in the NA gene. These
changes are outside the OST binding region, meaning that agathisflavone targets this viral enzyme at a
region different than conventional NAIs.

Conclusion:
Altogether our data suggest that agathisflavone has a promising chemical structure for the
development of anti-influenza drugs.
The Impact of Nitrogen Fixers and Phosphate Solubilizing Microbes on Sorghum (Sorghum bicolor) Yield
Authors: Vijayalakshmi V. , Pradeep S. , Manjunatha H. , Krishna V. , Jyothi V. 
Published: December 2019

Objective:
The inoculants, mainly nitrogen fixers and phosphate solubilizing microbes, have
an influence on plant growth attributes. The current study was conducted to assess the fertilizing activity
of A. chroocaccum and B. megaterium strains on growth, yield parameters and nutrient uptake of
Sorghum bicolor.

Methods:
The isolation and identification of the nitrogen-fixing bacterium- A. chroocaccum and phosphate
solubilizing microbe- B. megaterium and the growth and yield parameters of Sorghum bicolor as
well as NPK uptake levels were studied.

Results:
A. chroocaccum and B. megaterium exhibited the proliferation of microbial population in soil
by synergistic interaction with plants, and the application increased the availability of NPK in the soil
after harvest of the crop. These beneficial inoculants are also known to help in the uptake of some other
nutrients. The maximum beneficial aspects of the plant were noticed in the plants inoculated with
100% Recommended Dose of Fertilizer (RDF)+ A. chroocaccum+ B. megaterium, and the least was
noticed in the control plants at all growth stages and at the time of harvest.

Conclusion:
From this study, it can be concluded that the beneficial effect of A. chroocaccum and
B. megaterium is observed in sorghum crop with improved yield and nutrient uptake. Therefore, this
species can be used extensively for future inoculation of the sorghum crop for better growth and development
and for good returns in an ecological way.
Multi-Criteria Decision-Making Techniques for Asset Selection
Authors: Harode Shraddha , Jha Manoj , Srivastava Namita 
Published: December 2019

Background:
It has been a matter of discussion in years even after using an FST. Because
of being a single valued membership, a fuzzy set can't express desired information. Further extended
as HFSs which allows all possible membership degree lying between [0,1] is used widely where hesitancy
occurs in taking preference over matters in Decision Making.

Objective:
The aim in this paper is to create a diversified portfolio where the return is maximum and
the risk is minimal.

Methods:
Decision making methods like Fuzzy Soft Set, Mean Potentially Approach, and Soft Hesitant
Fuzzy Rough Set which are based on Fuzzy Soft Set theory for construct the optimal portfolio.
And non-fuzzy set method is applied for the optimal portfolio. It is found that a Soft hesitant fuzzy
rough set is best as compare to other methods. Then, the ratio of optimal portfolio is obtained with
the help of firefly optimization.

Results:
Soft Hesitant Fuzzy Rough Set has better outcomes on the basis of Performance Measure of
these methods. With the help of Soft Hesitant Fuzzy Rough Set, diversified portfolio is also constructed.
After constructing the optimal portfolio, Firefly algorithm is applied for obtain the proportions
of seven assets. It is clearly showing the firmness of the ranked portfolio having maximum return
and minimum risk on comparing without rank portfolio.

Conclusion:
Firefly algorithm is applied for optimization to the proportion of optimal assets of seven
assets. The main result is, return and dividend is better and risk is less when compared to without
ranking method. It is clear that the optimal portfolio with the ranking method is better than without
ranking method.
Designing an Expert System for the Diagnosis of Multiple Myeloma by Using Rough Set Theory
Authors: Karimi Tooraj , Hojati Arvin , Razavi Reza 
Published: December 2019

Background:
One of the most interesting and important topics in the field of information
systems and knowledge management is the concept of eliciting rules and collecting the knowledge
of human experts in various subjects to be used in expert systems. Many scientists have used decision
support systems to support businesses or organizational decision-making activities, including
clinical decision support systems for medical diagnosis.

Objective:
In this study, a rough set based expert system is designed for the diagnosis of one type of
blood cancer called multiple myeloma. In order to improve the validity of generated models, three
condition attributes that define the shape of “Total protein”, “Beta2%” and “Gamma%” are added
to the models to improve the decision attribute value domain.

Method:
In this study, 1100 serum protein electrophoresis tests are investigated and based on these
test results, 15 condition attributes are defined. Four different rule models are obtained through extracting
rules from reducts. Janson and Genetic Algorithm with "Full" and "ORR" approaches have
been used to generate reducts.

Results:
The GA/ORR of the information system with 87% accuracy is used as an inference engine
of an expert system and a unique user interface is designed to automatically analyze test results
based on these generated models. Gamma% is detected as a core attribute of the information system.

Conclusion:
Based on the results of generating reducts, the Gamma% attribute is detected as a core
of the information system. This means that information, which is resulted from this conditional attribute,
has the greatest impact on the diagnosis of multiple myeloma. The GA/ORR model with
87% accuracy is selected as the inference engine of the expert system and finally, a unique user interface
is created to help specialists diagnose multiple myeloma.
Efficacy and Safety of an mHealth App and Wearable Device in Physical Performance for Patients With Hepatocellular Carcinoma: Development and Usability Study
Authors: Kim Yoon , Seo Jinserk , An So-Yeon , Sinn Dong Hyun , Hwang Ji Hye 
Published: December 2019

Background
Exercise is predicted to have a positive effect among hepatocellular carcinoma (HCC) patients. However, these patients are hesitant to start and build up an exercise program for one major reason: the vague fear of developing hepatic decompensation, a potentially fatal condition that can lead to death. Integrating mobile health (mHealth) with individualized exercise programs could be a possible option for promoting physical capacity among HCC patients.

Objective
The aim of this study was to evaluate the efficacy and safety of rehabilitation exercises, which have been individually prescribed via an mHealth app, on physical fitness, body composition, biochemical profile, and quality of life among HCC patients.

Methods
A total of 37 HCC patients were enrolled in a 12-week course with an mHealth app program targeted to HCC patients. The wearable wristband device Neofit (Partron Co) was provided to participants, and recorded daily physical data, such as the number of steps, calorie expenditure, exercise time, and heart rate. Each participant was given an individualized rehabilitation exercise program that was prescribed and adjusted at the 6-week midintervention period based on the assessment results. At baseline, 6-week, and 12-week sessions, participants’ physical fitness levels (ie, 6-minute walk test, grip strength test, and 30-second chair stand test) were measured. Physical activity levels, as measured by the International Physical Activity Questionnaire-Short Form (IPAQ-SF); body composition (ie, body mass index, body fat percentage, and muscle mass); biochemical profiles; and quality of life, as measured by the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire C30, were assessed at baseline and at the end point. At the 6-week midpoint, exercise intensity was individually adjusted.

Results
Of the 37 patients, 31 (84%) completed the 12-week intervention. Grip strength improved significantly after 12 weeks of the intervention. The 30-second chair stand test and the 6-minute walk test showed significant improvement from 0 to 6 weeks, from 0 to 12 weeks, and from 6 to 12 weeks. Muscle mass and the IPAQ-SF score increased significantly after 12 weeks of the intervention without biochemical deterioration.

Conclusions
Following 12 weeks of mHealth care, including an individually prescribed rehabilitation exercise program, we saw significant improvements in physical fitness, body composition, and physical activity without any complication or biochemical deterioration among compensated HCC patients who had completed therapy.
Violência de gênero e a atuação da delegacia da mulher na Amazônia Parense
Authors: Neves Luciana C , Oliveira Marcelo V , Vieira Norma C 
Published: December 2019

Trata-se de pesquisa acerca da violência de gênero no município de Bragança, Amazônia Paraense e das práticas da Delegacia Especializada de Atendimento à Mulher (DEAM) Bragança/PRO PAZ Integrado – 6ª Região Integrada de Segurança Pública (RISP) Caeté. O objetivo geral é de analisar a prática dos agentes do Estado mediante as denúncias de violência de gênero, no ano de 2017. Constatamos que a DEAM Bragança, desde sua implantação, tem trabalhado no combate a violência de gênero no município de Bragança-PA; que o atendimento maioritário das profissionais da instituição pesquisada é voltado para as mulheres que se encontram em vulnerabilidade social e ressalta-se que a implantação dessa instituição no município pesquisado é um marco para a questão do combate à violência doméstica contra mulheres, crianças, adolescentes, idosos e idosas.
A Importância do contencioso do algodão: Brasil versus Estados Unidos para o projeto brasileiro de inserção internacional durante o governo Lula (2003-2010)
Authors: Guimarães Fernanda 
Published: December 2019

O presente trabalho é um estudo sobre a importância do contencioso sobre o comércio internacional de algodão entre Brasil e Estados Unidos para o projeto brasileiro de inserção internacional, tendo como referencial a política externa praticada pelo Governo Lula (2003-2010). Mais especificamente, busca compreender como a execução das diretrizes de política externa traçadas no período culminaram no destaque brasileiro no cenário internacional, processo que ficou evidente na sua posição como uma liderança frente à cooperação Sul-Sul, e também os determinantes do sucesso do país em negociar acordos comerciais favoráveis a seus interesses agrícolas na Organização Mundial do Comércio através do ganho de maior poder de barganha em meio às discussões relativas ao contencioso em questão. Dessa forma, o Brasil se pautou como uma importante economia em ascensão e ator de destaque para vocalizar as demandas e agendas do mundo em desenvolvimento no que tange às questões políticas e comerciais no cenário global. A análise pretendida será realizada através de uma contextualização sobre a construção de política externa brasileira durante o começo da década de 2000, seguido da apresentação do contencioso do algodão e, por fim, a análise crítica da forma como as negociações do contencioso refletiram em maior projeção internacional para o Brasil.
Promoting Religious Dimension in Conflict Resolution: A Review on Mohammed Abu-Nimer Thoughts
Authors: Rohman Muhammad Saifullah 
Published: December 2019

The aim of this paper is to review Mohammed Abu Nimer thoughts on the field of conflict resolution, peace-building, and inter-religious dialogues. As a thinker and practitioner of conflict resolution, he built his work based on his intimate relationship with conflicts. To review his thoughts, this paper traced and observed his main ideas about conflict resolution based on his writings; books, journals, articles, etc. Thus, the findings show that Mohammed Abu Nimer draws upon his thoughts by referring to his religion, Islam. Therefore, Islam as a religion supports peace-building of civilization through its teaching to Muslims. Although Islam became the basis of his works on conflict resolution, it does not mean that he insists it to be used in conflict resolution. His idea is promoting religious dimension in conflict resolution which makes religion as a source of peace rather than a source of conflict. Then, he proves the limit on peace-building and inter-religious dialogue as a means to reach peace between two sides of a conflict. Therefore, peace-building activists should acknowledge and accommodate any possible ways to mediate the conflicting parties in order to make peace.Â Keywords:Religious Dimension, Conflict Resolution, Peace-building, Dialogue
Public Fundraising for Financing Islamic Education and Dakwa Mission
Authors: Isbah M. Falikul 
Published: December 2019

Studies on Islamic education and Islamic propagation (dakwa) have not addressed the aspect of how particular actors fund their missions in Islamic education and dakwa. Based on a case study at Hidayatullah Islamic boarding school or Pesantren Hidayatullah, this article tries to correlate the issue of public fundraising and the financing of Islamic education and dakwa mission in contemporary Indonesia. Pesantren Hidayatullah conducts public fundraising program by forming a charity organization, namely Baitul Maal Hidayatullah (BMH). The finding reveals that the majority of the fund raised from public is used to finance Hidayatullahâ€™s schools and dakwa missions. This finding is in contrast to what have been suggested by other studies stating that charitable fund is supposed to be distributed back to the community based on the need criteria.Â Keywords:Public Fundrising, Islamic Education, Dakwaâ€™
Pesantren, Womenâ€™s Agency and Arranged Marriages in Indonesia
Authors: Wafiroh Nihayatul 
Published: December 2019

This paper is a case study based on the research of the process of arranged marriages in Pesantren. Arranged marriages have basically been a tradition in the world for a long time. In the process, the women involved in arranged marriages are often put in the position of an object and are considered to have no voice. Women have been seen as passive agents that do not contribute anything in the process of arranged marriages, whereas those who have full power in the process of arranged marriages in Pesantren are the Kyai or other male family members. This study took place in the five major Pesantren in East Java. One female informant, the daughter of a Kyai, was taken from each Pesantren so there were five informants. This research was conducted through in-depth interviews using the capital theory by Pierre Bourdieu, power relation by Michel Foucault, and women's agency by Sherry B. Ortner. This study reveals that Kyaiâ€™s daughters and wives, Nyai, are active agents, as well. Using the capital they have, women played their agencies in different ways to achieve certain goals. They engage in critiques on the habitus practice of arranged marriages. They also negotiate and resist when the arranged marriage process runs. This study confirms that doing research focused on womenâ€™s voice can expose additional aspects of womenâ€™s agency that have been widely ignored.Â Keywords:Pesantren, Womenâ€™s agency, Arranged marriages
Yhteisymmärryksen rakentamisen monet keinot
Authors: Lehtinen Esa 
Published: December 2019

Arvioitu teos
Jenny Paananen: Yhteisymmärryksen rakentaminen monikulttuurisilla lääkärin vastaanotoilla. Turun yliopistonjulkaisuja – Annales Universitatis Turkuensis, Sarja – Ser. C Osa – Tom. 465. Scripta Lingua Fennica Edita. Turku: Turun yliopisto 2019. isbn 978-951-29-7556-3. Johdanto 119 s., artikkelit 132 s. Luettavissa verkossa osoitteessa http://urn.fi/URN:ISBN:978-951-29-7557-0.
Kirjallisuus kohtaa tabloidisaation: Pienempi sivukoko ja Helsingin Sanomien kulttuurijournalismin muutos
Authors: Hellman Heikki , Ruohonen Voitto 
Published: December 2019

Tabloidisaatiohypoteesiksi kutsutun oletuksen mukaan tabloidiformaattiin siirtyminen tiivistää lehteä sekä tuo muutoksia journalismin muoto- ja keinovalikoimaan lyhentämällä tekstejä, lisäämällä kuvien käyttöä ja keventämällä lehden sisältöjä. Artikkelissa verrataan sisällönanalyysin avulla Helsingin Sanomien kulttuurijournalismin sisällöllisiä painotuksia sekä erityisesti kirjallisuusjournalismin muotoja ja puhuttelutapoja syksyllä 2011 ja syksyllä 2016, ennen ja jälkeen tammikuussa 2013 tapahtuneen tabloidisiirtymän. Määrällinen analyysi osoittaa, että tabloidisaatio ei toteudu suoraviivaisesti, vaan se voi johtaa keskenään ristiriitaisiin ja tabloidisaatiohypoteesin kannalta osin odottamattomiin seurauksiin. Vaikka lehti uudistuksen myötä tiivistyi ja juttujen määrä väheni, vastoin odotuksia kulttuurisivujen palstatila kasvoi, jutut pidentyivät ja niiden palastelu väheni. Pienempi koko suosi feature- ja henkilölähtöistä journalismia ja lisääntynyttä kuvien käyttöä, mutta odotusten vastaisesti myös arvostelujen suhteellinen asema hienokseltaan vahvistui.
Analisis Perancangan Bio Briket Biji Salak Menggunakan Bisnis Model Kanvas
Authors: Saleh Andri 
Published: December 2019

Indonesia merupakan negara agraris yang artinya sektor pertanian memiliki peranan yang sangat penting. Sektor pertanian juga meliputi perkebunan yang memberikan sumbangsih yang cukup signifikan untuk perekonomian negara. Diantara hasil perkebunan itu berupa sayur mayur dan buah buahan. Untuk produksi buah-buahan khususnya buah salak di Indonesia menempati urutan kelima dengan produksi sebesar 1.118.953 ton atau sekitar 5,65 % terhadap total produksi buah nasional. Padangsidimpuan merupakan salah satu kota di Sumatera Utara yang sebagian besar penduduknya bekerja sebagai petani salak dansalak merupakan komoditi pertanian yang banyak dijumpai di kota Padangsidimpuan adalah salak. Luas lahan tanaman salak di Padangsidimpuan berkisar 460 Ha dengan jumlah produksi 426.758 ton/tahun. Salah satu energi alternatif yang terus dikembangkan adalah briket. Briket merupakan bahan bakar yang berwujud padat yang terbuat dari sisa limbah biomassa. Salah satu limbah yang cukup banyakselain kulit adalah biji salak yang menjadi perhatian untuk di daur ulang sebagai energi alternatif. Briket dari biji salak merupakan ide yang cukup tepat untuk dikembangkan dalam perancangan produk bernilai ekonomis karena memiliki nilai kalor yang tinggi berdasarkan penelitian awal yang sudah dilakukan yaitu 7,058 kKal/gram. Nilai ini memenuhi nilai Standar Nasiona Indonesia dan juga Nilai Standar Internasional. Perancangan Biobriket dengan metode Design for Manufacturing dan bisnis model kanvas diawali dengan menghitung Harga Pokok Produksi (HPP) , setiap memproduksi 1kg briket membutuhkan HPP sebesar Rp 5,90,- dengan asumsi harga jual 50%, maka harga jual briket tersebut sebesar Rp 8.85,-/kg. Dari hasil Analisa Business Model Canvas yang dilakukan pada pembuatan briket biji salak Model Bisnis yang dihasilkan dari pengembangan pasar produk briket biji salak dan ampas tebu disesuaikan dari kebutuhan masyarkat khususnya kalangan ibu rumah tangga dan pedagang kecil. Segi pelayanan juga bisa dimaksimalkan untuk menyesuaikan permintaan konsumen. Permasalahan channel yang dialami dalam peningkatan penjualan briket biji salak dapat ditanggulangi karna adanya analisa potensi market place yang akan menjadi target pasar untuk mendukung realisasi dan memaksimalkan potensi bisnis briket.
L’INTERVENANT DOIT ÊTRE UN PROBLÈME POUR LES ENFANTS !
Authors: CORTIAL Cédric 
Published: December 2019

The Intervenient Must be a Problem for the Children! This article attempts to find a theoretically and philosophically consistant foundation for the role of the facilitator of philosophy with children and draws conclusions about the type of activity that this facilitator must do. This requires a thetic implication on what makes us philosophize. We defend then that it is by the concept of problem that the philosophy appears, and that thus the facilitator must act by being an instantiation of this very concept.
Aspergiloma pulmonar en paciente con síndrome de sobreposición: Reporte de caso
Authors: Rozo Ortiz Edwar Jassir , Vargas Rodriguez Ledmar Jovanny , Agudelo Sanabria Milena Brigitte 
Published: December 2019

Introducción: La infección por Aspergillus spp. representa un reto diagnóstico y terapéutico para el clínico, puesto que existe un número aproximado de 180 especies. El pulmón es el principal órgano afectado por el Aspergillus debido a la alta capacidad esporulativa de este hongo, y a que sus conidias son lo suficientemente pequeñas para poder alcanzar el alveolo. Caso: Mujer de 41 años de edad con antecedente de lupus eritematoso sistémico, ingresó con un cuadro de disfagia, en el cual se confirmó la presencia de síndrome de sobreposición mediante perfil inmunológico. Posteriormente, mediante estudio imagenológico, realizado por tener tos y disnea, se encontró la presencia de una masa ovoidea en hemitorax derecho y al realizar una fibrobroncoscopia se evidenció que dicha lesión era compatible con un aspergiloma, por lo que se dio manejo antifúngico con una evolución clínica adecuada. Conclusión: El aspergiloma se presenta como una masa voluminosa constituida por filamentos miceliales, la cual se puede confundir con múltiples patologías principalmente de tipo tumoral, por lo que es necesario realizar biopsia de la misma.
Validating a destructive measurement system using Gauge R&R — a case study
Authors: Sharma Mithun , Sahni Sanjeev P. , Sharma Shilpi 
Published: December 2019

Abstract
The research study aims to evaluate the precision of the measurement system using Gauge R&R. An experimental research design adopting a positivist empirical approach with deductive strategy was followed to assess the effectiveness of Crossed Gauge R&R technique for validating a measurement system using destructive testing. Crossed Gauge R&R technique in Minitab was found to be highly effective in quantifying different components of measurement variation relative to process variation. Clue generation from the Crossed Gauge R&R study combined with manufacturing and measurement process know-how helped in identifying and eliminating the root causes for measurement variation. Overall Crossed Gauge R&R proved successful in validating the burst strength test equipment. However, it should be noted that manufacturing and test equipment played an equally important part in developing and executing the gauge R&R study and accurately analysing the results. So, Crossed Gauge R&R should be used as an aid rather than the solution for measurement system validation.