bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variations in neonatal mortality, infant mortality, preterm birth and birth weight in England and Wales according to ethnicity and maternal country or region of birth: an analysis of linked national data from 2006 to 2012
Authors: Opondo Charles , Jayaweera Hiranthi , Hollowell Jennifer , Li Yangmei , Kurinczuk Jennifer J , Quigley Maria A 
Published: January 2020

BackgroundRisks of adverse birth outcomes in England and Wales are relatively low but vary across ethnic groups. We aimed to explore the role of mother’s country of birth on birth outcomes across ethnic groups using a large population-based linked data set.MethodsWe used a cohort of 4.6 million singleton live births in England and Wales to estimate relative risks of neonatal mortality, infant mortality and preterm birth, and differences in birth weight, comparing infants of UK-born mothers to infants whose mothers were born in their countries or regions of ethnic origin, or elsewhere.ResultsThe crude neonatal and infant death risks were 2.1 and 3.2 per 1000, respectively, the crude preterm birth risk was 5.6% and the crude mean birth weight was 3.36 kg. Pooling across all ethnic groups, infants of mothers born in their countries or regions of ethnic origin had lower adjusted risks of death and preterm birth, and higher gestational age-adjusted mean birth weights than those of UK-born mothers. White British infants of non-UK-born mothers had slightly lower gestational age-adjusted mean birth weights than White British infants of UK-born mothers (mean difference −3 g, 95% CI −5 g to −0.3 g). Pakistani infants of Pakistan-born mothers had lower adjusted risks of neonatal death (adjusted risk ratio (aRR) 0.84, 95% CI 0.72 to 0.98), infant death (aRR 0.84, 95% CI 0.75 to 0.94) and preterm birth (aRR 0.85, 95% CI 0.82 to 0.88) than Pakistani infants of UK-born Pakistani mothers. Indian infants of India-born mothers had lower adjusted preterm birth risk (aRR 0.91, 95% CI 0.87 to 0.96) than Indian infants of UK-born Indian mothers. There was no evidence of a difference by mother’s country of birth in risk of birth outcomes among Black infants, except Black Caribbean infants of mothers born in neither the UK nor their region of origin, who had higher neonatal death risks (aRR 1.71, 95% CI 1.06 to 2.76).ConclusionThis study highlights evidence of better birth outcomes among UK-born infants of non-UK-born minority ethnic group mothers, and could inform the design of future interventions to reduce the risks of adverse birth outcomes through improved targeting of at-risk groups.
Are self-reported health inequalities widening by income? An analysis of British pseudo birth cohorts born, 1920–1970
Authors: Jivraj Stephen 
Published: January 2020

IntroductionThe health of the British population has been shown to be worsening by self-reported health and improving by self-reported limiting illness for those born before and after 1945. Little is known about the inequality in health difference across British birth cohorts by income.MethodsRepeated cross-sections from the British General Household Survey, 1979–2011, are used to create pseudo birth cohorts born, 1920–1970, and their gender stratified, age-adjusted limiting illness and self-rated health (SRH) are estimated by household income tertiles. Absolute and relative differences between the poorest and richest income groups are reported.ResultsAbsolute inequalities in limiting illness between the richest and poorest households have doubled in women and increased by one and a half times in men for those born in 1920–1922 compared with those born in 1968–1970. Relative inequalities in limiting illness increased by a half in women and doubled in men. Absolute inequalities in SRH between the richest and poorest households increased by almost half in women and more than half in men and relative inequalities increased by 18% in women and 14% in men for those born in 1920–1922 compared with those born in 1968–1970.ConclusionInequalities in self-reported health at the same age by household income have widened for successively later-born British cohorts.
Effects of combined histamine H1 and H2 receptor blockade on hemodynamic responses to dynamic exercise in males with high-normal blood pressure
Authors: Naylor Ashley , Shariffi Brian , Gillum Trevor L. , William Boyer , Sullivan Sean , Kim Jong-Kyung 
Published: January 2020

While postexercise hypotension is associated with histamine H1 and H2 receptor-mediated postexercise vasodilation, effects of histaminergic vasodilation on blood pressure (BP) in response to dynamic exercise are not known. Thus, in 20 recreationally active male participants (10 normotensive and 10 with high-normal BP) we examined the effects of histamine H1 and H2 receptor blockade on cardiac output (CO), mean atrial pressure (MAP), aortic stiffness (AoStiff), and total vascular conductance (TVC) at rest and during progressive cycling exercise. Compared with the normotensive group, MAP, CO, and AoStiff were higher in the high-normal group before and after the blockade at rest, while TVC was similar. At the 40% workload, the blockade significantly increased MAP in both groups, while no difference was found in the TVC. CO was higher in the high-normal group than the normotensive group in both conditions. At the 60% workload, the blockade substantially increased MAP and decreased TVC in the normotensive group, while there were no changes in the high-normal group. A similar CO response pattern was observed at the 60% workload. These findings suggest that the mechanism eliciting an exaggerated BP response to exercise in the high-normal group may be partially due to the inability of histamine receptors. Novelty Males with high-normal BP had an exaggerated BP response to exercise. The overactive BP response is known due to an increase in peripheral vasoconstriction. Increase in peripheral vasoconstriction is partially due to inability of histamine receptors.
An improved laboratory method shows that freezing intensity increases N2O emissions
Authors: Libby Mark D. , VanderZaag Andrew C. , Gregorich Edward G. , Wagner-Riddle Claudia 
Published: January 2020

A novel laboratory method was developed to control soil freeze–thaw cycles and study the effects of freezing intensity on soil conditions and N2O emissions. The method created unidirectional freeze–thaw (top-down), similar to field conditions. Soil was placed in boxes that were insulated on the sides, heated from the bottom, and left open on the top. Snow was placed on the soil surface, and the boxes were placed in separate climate-controlled chambers to freeze (−9 °C) and thaw (5 °C). The method was used in an experiment to evaluate the links between freezing degree days (FDD), soil water content, carbon (C) and nitrogen (N) transformations, and N2O emissions. Results showed that N2O emissions were greatest from soils that experienced more freezing, with the 185 FDD treatment emitting significantly more N2O than the 50 FDD treatment (17.7 vs. 7.7 mg N2O-N m−2d−1). Peaks in soil water content during thaw preceded peaks in N2O flux, but increasing water content by simulating rain (in addition to snow melt) did not increase N2O emissions compared with snow melt alone. Extractable soil C and N increased in the top 5 cm when soils froze; however, greater emissions were not linked to greater C and N concentrations at individual points in time. Higher N2O emissions at 134 and 185 FDD were associated with greater C exposure (i.e., extractable soil C concentration integrated over time) than the 50 FDD treatment.
Characterizing effects of mechanical compaction on macropores of reclaimed soil using computed tomography scanning
Authors: Min Xiangyu , Jiao He , Li Xinju 
Published: January 2020

To study the effects of mechanical compaction on soil macropore structure in the process of reclamation, this study investigated reclaimed soil mechanically compacted in coal mining area with high groundwater level. The computed tomography scanning technology was employed to get soil slice images, and ArcGIS® was used to analyze the porosity, number, size, morphology, and distribution of macropores in reclaimed soil, at different compaction times (0, 1, 3, 5, 7, and 9) and depths (0–20, 20–40, and 40–60 cm). Our results proved that the mechanical compaction could decrease the macroporosity, number, and equivalent diameter (ED) of the macropores in reclaimed soil, while the morphology became rounded. The distribution of macropore ED was steeper and more asymmetrical than macropore circularity. However, mechanical compaction could make them flat and symmetrical. The macroporosity, number, ED, and circularity of macropores in packing layer (40–60 cm) were smaller than backfilling top layer (0–20 cm) and sublayer (20–40 cm). Thus, we suggest that subsoiling in packing layer is responsible for the improved macropore characteristics. Moreover, these macropores will possess better permeability if the compaction times are controlled.
Unearthing the buried Palu–Koro Fault and the pattern of damage caused by the 2018 Sulawesi Earthquake using HVSR inversion
Authors: Cipta Athanasius , Rudyanto Ariska , Afif Haunan , Robiana Rahayu , Solikhin Akhmad , Omang Amalfi , Supartoyo  , Hidayati Sri 
Published: January 2020

Abstract

A systematic pattern of destruction was observed caused by the Mw 7.5 Central Sulawesi Earthquake. In brief, the quake ruptured 180 km of Palu–Koro Fault and led to massive destruction of residential buildings in Palu city, Donggala and Sigi Regencies. In Palu city, the damage was concentrated only in Balaroa and Petobo neighbourhoods where at least 930 and 1255 houses, respectively, collapsed. Microtremor time series recorded prior to the earthquake were used to analyse the subsurface structure of Balaroa and surroundings. Surprisingly, inversion of horizontal-to-vertical spectral ratio curves was able to locate the subsurface fault crossing the Balaroa and its dipping direction. Furthermore, the velocity profile deduced from this inversion points out the importance of local geology in the massive destruction in Balaroa. The existence of a subsurface pond led to an extremely water-saturated sandy soil underneath Balaroa. A combination of high level of water saturation and high peak ground acceleration (0.5–0.7 g) was strongly suspected to be the cause of the mega-liquefaction. The high degree of ground motion (>1.54 g) of spectral acceleration 0.2 s resulted in severe damage in elevated areas in Donggala, while in the Palu Basin, ground motion as high as 1.30

g

of spectral acceleration 0.5 s led to the destruction of four-storey or higher buildings.
Efficacy and Safety of Duvelisib Following Disease Progression on Ofatumumab in Patients with Relapsed/Refractory CLL or SLL in the DUO Crossover Extension Study
Authors: Davids Matthew S. , Kuss Bryone J. , Hillmen Peter , Montillo Marco , Moreno Carol , Essell James , Lamanna Nicole , Nagy Zsolt , Tam Constantine S. , Stilgenbauer Stephan , Ghia Paolo , Delgado Julio , Lustgarten Stephanie , Weaver David T. , Youssoufian Hagop , Jäger Ulrich 
Published: January 2020

Abstract

Purpose:
In the phase III DUO trial, duvelisib, an oral dual PI3K-δ,γ inhibitor, demonstrated significantly improved efficacy versus ofatumumab [median (m) progression-free survival (PFS), 13.3 vs. 9.9 months (HR, 0.52; P &lt; 0.0001); overall response rate [ORR], 74% vs. 45% (P &lt; 0.0001)], with a manageable safety profile in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). We report results from patients with progressive disease (PD) after ofatumumab who crossed over to duvelisib in the DUO trial.

Patients and Methods:
Patients with radiographically confirmed PD after ofatumumab received duvelisib 25 mg twice daily in 28-day cycles until PD, intolerance, death, or study withdrawal. The primary endpoint was ORR per investigator. Secondary endpoints included duration of response (DOR), PFS, and safety.

Results:
As of December 14, 2018, 90 ofatumumab-treated patients in the DUO trial prior to crossover had an ORR of 29%, mDOR of 10.4 months, and mPFS of 9.4 months. After crossover, 77% of patients (69/90) achieved a response, with an mDOR of 14.9 months and mPFS of 15.7 months. Patients with del(17p) and/or TP53 mutations had similar outcomes [ORR, 77% (20/26); mPFS, 14.7 months]. Notably, 73% of patients (47/64) with disease previously refractory to ofatumumab achieved a response. The most frequent any-grade/grade 3/4 treatment-emergent adverse events were diarrhea (47%/23%), neutropenia (26%/23%), pyrexia (24%/4%), cutaneous reactions (23%/4%), and thrombocytopenia (10%/6%).

Conclusions:
Duvelisib demonstrated high response rates with good durability and a manageable safety profile in patients with R/R CLL/SLL who progressed on ofatumumab, including patients with high-risk disease and disease previously refractory to ofatumumab.
CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies
Authors: Quayle Steven N. , Girgis Natasha , Thapa Dharma R. , Merazga Zohra , Kemp Melissa M. , Histed Alex , Zhao Fan , Moreta Miguel , Ruthardt Paige , Hulot Sandrine , Nelson Alyssa , Kraemer Lauren D. , Beal Dominic R. , Witt Luke , Ryabin Jessica , Soriano Jonathan , Haydock Mark , Spaulding Emily , Ross John F. , Kiener Peter A. , Almo Steven , Chaparro Rodolfo , Seidel Ronald , Suri Anish , Cemerski Saso , Pienta Kenneth J. , Simcox Mary Ellen 
Published: January 2020

AbstractPurpose:To assess the potential for CUE-101, a novel therapeutic fusion protein, to selectively activate and expand HPV16 E711-20-specific CD8+ T cells as an off-the shelf therapy for the treatment of HPV16-driven tumors, including head and neck squamous cell carcinoma (HNSCC), cervical, and anal cancers.Experimental Design:CUE-101 is an Fc fusion protein composed of a human leukocyte antigen (HLA) complex, an HPV16 E7 peptide epitope, reduced affinity human IL2 molecules, and an effector attenuated human IgG1 Fc domain. Human E7-specific T cells and human peripheral blood mononuclear cells (PBMC) were tested to demonstrate cellular activity and specificity of CUE-101, whereas in vivo activity of CUE-101 was assessed in HLA-A2 transgenic mice. Antitumor efficacy with a murine surrogate (mCUE-101) was tested in the TC-1 syngeneic tumor model.Results:CUE-101 demonstrates selective binding, activation, and expansion of HPV16 E711-20-specific CD8+ T cells from PBMCs relative to nontarget cells. Intravenous administration of CUE-101 induced selective expansion of HPV16 E711-20-specific CD8+ T cells in HLA-A2 (AAD) transgenic mice, and anticancer efficacy and immunologic memory was demonstrated in TC-1 tumor-bearing mice treated with mCUE-101. Combination therapy with anti-PD-1 checkpoint blockade further enhanced the observed efficacy.Conclusions:Consistent with its design, CUE-101 demonstrates selective expansion of an HPV16 E711-20-specific population of cytotoxic CD8+ T cells, a favorable safety profile, and in vitro and in vivo evidence supporting its potential for clinical efficacy in an ongoing phase I trial (NCT03978689).
Cystatin C- Versus Creatinine-Based Assessment of Renal Function and Prediction of Early Outcomes Among Patients With a Left Ventricular Assist Device
Authors: Pinsino Alberto , Mondellini Giulio M. , Royzman Eugene A. , Hoffman Katherine L. , D’Angelo Debra , Mabasa Melissa , Gaudig Antonia , Zuver Amelia M. , Masoumi Amirali , Garan A. Reshad , Mohan Sumit , Husain Syed A. , Toma Katherine , Faillace Robert T. , Giles Jon T. , Takeda Koji , Takayama Hiroo , Naka Yoshifumi , Topkara Veli K. , Demmer Ryan T. , Radhakrishnan Jai , Colombo Paolo C. , Yuzefpolskaya Melana 
Published: January 2020

Background:
Estimated glomerular filtration rate (eGFR) based on serum creatinine (sCr) improves early after left ventricular assist device (LVAD) implantation but subsequently declines. Although sCr is a commonly accepted clinical standard, cystatin C (CysC) has shown superiority in assessment of renal function in disease states characterized by muscle wasting. Among patients with an LVAD, we aimed to (1) longitudinally compare CysC-eGFR and sCr-eGFR, (2) assess their predictive value for early postoperative outcomes, and (3) investigate mechanisms which might explain potential discrepancies.

Methods:
A prospective cohort (n=116) with CysC and sCr concurrently measured at serial time points, and a retrospective cohort (n=91) with chest computed tomography performed within 40 days post-LVAD were studied. In the prospective cohort, the primary end point was a composite of in-hospital mortality, renal replacement therapy, or severe right ventricular failure. In the retrospective cohort, muscle mass was estimated using pectoralis muscle area indexed to body surface area (pectoralis muscle index).

Results:

In the prospective cohort, sCr-eGFR significantly improved early post-LVAD and subsequently declined, whereas CysC-eGFR remained stable. CysC-eGFR but not sCr-eGFR predicted the primary end point: odds ratio per 5 mL/(min·1.73 m
2
) decrease 1.16 (1.02–1.31) versus 0.99 (0.94–1.05). In retrospective cohort, for every 5 days post-LVAD, a 6% decrease in pectoralis muscle index was observed (95% CI, 2%–9%,
P
=0.003). After adjusting for time on LVAD, for every 1 cm
2
/m
2
decrease in pectoralis muscle index, there was a 4% decrease in 30-day post-LVAD sCr (95% CI, 1%–6%,
P
=0.004).

Conclusions:
Initial improvement in sCr-eGFR is likely due to muscle wasting following LVAD surgery. CysC may improve assessment of renal function and prediction of early postoperative outcomes in patients with an LVAD.
6. A Note on the Navigation Space of the Baris-Type Ships from Thonis-Heracleion
Authors: Belov Alexander 
Published: January 2020

‘Painting ships’ (naves pingere), as Pliny the Elder said about the activities of the painter Protogenes (‘until the age of fifty he was also a ship painter…’), may have two meanings: the first is to adorn ships; the second consists of representing ships in paintings. During Alexander’s funerals, the painter Apelles — or his workshop — may have produced four panels adorning the hearse of the Conqueror and celebrating the military power of the Macedonian. Among these depictions was his war fleet. However, this picture, linked to the event that defines the early Hellenistic period, is neither the first nor the only one to represent ships. This chapter will explore these two very different pictorial exercises over a long period of time.
Few artists are described as ‘ship painters’. As a prefect of the imperial war fleet in Misenum, Pliny knew ships very well. Therefore, in calling someone a ship painter, he might imply both artistic and technical expertise. We should therefore pay particular attention to the work of Protogenes. What precisely was a ship painter in the ancient Mediterranean?
Inter- and Intra-Rater Reliability of Laryngeal Sensation Testing with the Touch Method During Flexible Endoscopic Evaluations of Swallowing
Authors: Borders James C. , O’Dea Meredith B. , McNally Edel , Norberg Elizabeth , Kitila Merertu , Walsh Michael , Liu Rui , Pisegna Jessica M. 
Published: January 2020

Objectives: Sensation is an integral component of laryngeal control for breathing, swallowing, and vocalization. Laryngeal sensation is assessed by elicitation of the laryngeal adductor reflex (LAR), a brainstem-mediated adduction of the true vocal folds. During Flexible Endoscopic Evaluations of Swallowing (FEES), the touch method can be used to elicit the LAR to judge laryngeal sensation. Despite the prevalence of this method in clinical practice and research, prior studies have yet to examine inter- and intra-rater reliability. Methods: Four speech-language pathologists rated 125 randomized video clips for the presence, absence, or inability to rate the LAR. Fifty percent of video clips were re-randomized and re-rated 1 week later. Raters then created guidelines and participated in formal consensus training sessions on a separate set of videos. Ratings were repeated post-training. Results: Overall inter-rater reliability was fair (κ = 0.22) prior to training. Pre-training intra-rater reliability ranged from fair (κ = 0.35) to almost perfect (κ = 0.89). Inter-rater reliability significantly improved after training (κ = 0.42, P < .001), though agreement did not reach prespecified acceptable levels (κ ≥ 0.80). Post-training intra-rater reliability ranged from moderate (κ = 0.49) to almost perfect (κ = 0.85). Conclusion: Adequate inter-rater reliability was not achieved when rating isolated attempts to elicit the LAR. Acceptable within-rater reliability was observed in some raters 1 week after initial ratings, suggesting that ratings may remain consistent within raters over a short period of time. Limitations and considerations for future research using the touch method are discussed.
Use of case stories to explore the contextual application of cardiovascular health knowledge in Nigeria
Authors: Ezika Ejiofor A 
Published: January 2020

Objective: The objective of this study was to explore the impact of the use of case stories on promoting cardiovascular health (CVH) knowledge as well as determining the contextual application of CVH knowledge in an urban population in Nigeria. Design: Participatory action research. Setting: Urban setting in Nigeria. Method: Fifty participants were recruited through convenience sampling from an urban population in Nigeria. The researcher in collaboration with two faith leaders, a tribal leader and participants designed two case-based learning tools that were used to facilitate community health education that lasted for 16 weeks and which incorporated the promotion of physical activity and healthy eating twice a week over the same period. The impact of the health education intervention on knowledge concerning cardiovascular disease (CVD) risk factors was determined using McNemar’s test. Results: Overall, 34% of the participants were able to give relevant pieces of advice relating to the two case-based learning scenarios about improving CVH. This percentage is lower compared with overall 76% of the participants who identified modifiable risk factors contributing to CVD in a questionnaire format before the health education session. Although participants were able to identify correct responses in a questionnaire format, it appeared more difficult for them to apply contextualised knowledge using the case-based learning tools. This suggests that the use of case-based learning tools is more realistic to life experience. Conclusion: Raising awareness of modifiable risk factors that contribute to CVD using case-based learning can be an important approach to reaching urban communities. Case-based learning is a useful tool to promote CVH knowledge.