bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetic Neuropathy Pain Management: A Global Challenge
Authors: Qureshi Zunaira , Ali Murtaza N. 
Published: November 2020

Background:
Painful Diabetic Neuropathy (PDN) is a devastating condition affecting
one in three people with diabetes.

Introduction:
Keeping in mind the unceasingly escalating prevalence of diabetes mellitus worldwide,
the number of PDN patients is also expected to rise with a reduced quality of life in patients
and a staggering increase in healthcare costs. Despite relentless efforts and continuous research, the
commercially available medications for relieving diabetic neuropathy pain are only partially effective
with substantial side effects. This is, in part, due to our partial awareness of the underlying
complexities causing PDN. The pathogenesis of PDN remains elusive because of the difficulty in
obtaining damaged nerve samples and the absence of non-invasive methods to investigate the
pathogenesis at different stages of disease progression. The purpose of this review was to describe
pathogenesis, clinical manifestations and treatment options for PDN.

Methods:
The keywords relevant to the scope of this paper were put in electronic databases
(PubMed and Google Scholar) to fetch the relevant data. The data were then analyzed and
compiled.

Results:
A simplified overview of PDN for researchers new to the field has been provided in an attempt
to clarify common confusions. The changes in skin structure and functions in response to diabetes,
diabetic neuropathy and painful diabetic neuropathy are also discussed. The unavailability of
an efficacious pain reliever for PDN stresses on the need for identifying the microenvironmental
factors that are altered in PDN and manipulate them to tailor targeted theranostics.

Conclusion:
In the end, we proposed to consider the altered skin structure, function and microenvironmental
factors in the diabetic population for devising smart, targeted, stimuli-responsive treatment
options to attain maximum pain relief with minimum side effects.
Can Edible Insects Complement Conventional Livestock? The Desirability of Insect Nutrition for Food Security of a World Heritage Site and Biosphere Reserve
Authors: Hazarika Arup K. , Kalita Unmilan , Khanna Subhash 
Published: November 2020

Background:
Insects have formed a part of the human diet since pre-historic times. Entomophagy
has garnered recent attention due to its increased role in food security as nutrient-rich alternatives
of conventional livestock.

Methods:
We have made an effort in this paper to study the edible insect composition of Manas National
Park, a UNESCO Natural World Heritage Site and Biosphere Reserve, located in the Indo-
Burma biodiversity hotspot of Southern Asia. Edible insect variety was determined through a
field reconnaissance while the nutrient composition (macronutrient and micronutrient) of each edible
insect species was computed through biochemical analyses with a view to explore the possibility
of promoting them as food/feed or as a base for nutritive products. We conducted nutrient profiling
using the Nutrient Value Score (NVS) model and UK Ofcom nutrient profiling (NP) model.

Results:
Hymenoptera and Orthoptera were found to be the dominant orders with 4 species each,
followed by Hemiptera with 3 species, Lepidoptera with 2 species, Mantodea, Blattodea and
Coleoptera with 1 species each. The nutrient analysis shows that insects have a rich nutrient composition
that is comparable with typical livestock.

Conclusion:
As realised during COVID-19, insects may prove to be an alternative, sustainable,
and cheaper sources of nutrients necessary for ensuring global food security.
Development, Validation, and Application of a High-Performance Liquid Chromatography Method for the Analysis of Dissolution Samples of Telmisartan and Rosuvastatin Calcium Double-Layer Formulation
Authors: Lee Sang-Ho , Lee Sang-Ho , Lee Jong-Hyuk , Kim Joo-Eun 
Published: November 2020

Background:
Telmisartan and rosuvastatin calcium fixed-dose combination double-layer
tablet is used for hypertension and hyperlipidemia treatment. Owing to the critical problem in establishing
the specificity, precision, and accuracy of the USP analysis method and simultaneous analysis
method for both components, an analysis method that could be applied to researchers in the field is
urgently needed.

Objective:
To develop and validate a reversed phase-high-performance liquid chromatography method
for the quantitative analysis of dissolution samples of telmisartan and rosuvastatin calcium fixed-dose
combination double-layer tablets, as a hypertension and hyperlipidemia treatment.

Methods:
The developed analysis method was validated according to USP Category I requirements.
The validity of the quantitative assay of the dissolution test solution was determined based on the system
suitability, specificity, linearity, accuracy, precision, and solution stability of the assay for the components.

Results:
The developed method was selective and precise. The retention times of telmisartan and rosuvastatin
calcium was 8.1 min and 2.8 min, respectively, and system suitability was 0.217 and 0.17, respectively.
Both components showed linearity at 10–120% concentration. The accuracy and precision
were also within acceptable limits. The drugs in the dissolution samples were stable for a long time, no
interaction occurred between the excipients and active pharmaceutical ingredients, and no interference
was observed in the analysis.

Conclusion:
The quantitative analysis of the double-layered formulation of telmisartan and rosuvastatin
calcium was accurate, selective, and precise. Therefore, this method can be recommended for use in the
industrial quality control of telmisartan and rosuvastatin calcium formulations.
Prospects of Treating Tenosynovial Giant Cell Tumor through Pexidartinib: A Review
Authors: Alsayadi Yunes M.M.A. , Chawla Pooja A. 
Published: November 2020

Background:
Tenosynovial giant cell tumor refers to a group of rarely occurring tumors that are
formed in the joints, which are characterized by pain, swelling, and limitation of movement of the joint. Surgery
is the main treatment strategy, but the tumor is likely to recur, especially in pigmented villonodular synovitis,
which is the diffuse-type giant cell tumor. Pexidartinib was approved in August 2019 by the Food and Drug
Administration (FDA) with a brand name TURALIO as the first systemic approved therapy for patients having
Tenosynovial Giant Cell Tumors (TGCT).

Objective:
In this review, different aspects pertaining to pexidartinib have been summarized, including the
pathophysiology of TGCT, chemistry, pharmacokinetics and pharmacodynamics of pexidartinib. Special
attention is given to various reported clinical trials of pexidartinib.

Methods:
A comprehensive literature search was conducted in the relevant databases to identify studies
published in this field during recent years.

Conclusion:
Pexidartinib acts by inhibiting the Colony-Stimulating Factor (CSF1)/CSF1 receptor pathway,
which leads to the inhibition of the cell lines proliferation and promotes the autophosphorylation process of the
ligand-induced CSF1 receptor. Pexidartinib emerged as a potential drug candidate for the treatment of TGCT.
Optimization of Scattering Parameters Through Numerical Investigation of One-Bit RF MEMS Switch Over Ku, K and Ka Band
Authors: Debnath Pampa , Mondal Ujjwal , Deyasi Arpan 
Published: November 2020

Aim:
Computation of loss factors for one-bit RF MEMS switch over Ku, K and Ka-band for two different insulating substrates.

Objective:
Numerical investigation of return loss, insertion loss, isolation loss are computed under both actuated
and unactuated states for two different insulating substrates of the 1-bit RF MEMS switch, and
corresponding up and down-capacitances are obtained.

Methods:
The unique characteristics of a 1-bit RF MEMS switch of providing higher return loss under both
actuated and unactuated states and also of isolation loss with negligible insertion loss makes it as a
prime candidate for phase shifter application. This is presented in this manuscript with a keen focus
on improvement capability by changing transmission line width, and also of overlap area; where
dielectric constant of the substrate also plays a vital role.

Results:
The present work exhibits very low down-capacitance over the spectrum whereas considerable
amount of up-capacitance. Also when overall performance in terms of all loss parameters are
considered, switch provides very low insertion loss, good return loss under actuated state and standard
isolation loss.

Conclusion:
Reduction of transmission line width of about 33% improved the performance of the
switch by increasing isolation loss. Isolation loss of -40 dB is obtained at actuated condition in higher
microwave spectra for SiO2 at higher overlap area. Down capacitance of ~ 1dB is obtained which is
novel as compared with other published literature. Moreover, a better combination of both return loss,
isolation loss and insertion loss are reported in this present work compared with all other published data
so far.
Software Reliability Growth Model with Rate of Change in Application Characteristics
Authors: Sharma Himanshu , Mehta Prarna , Tandon Abhishek 
Published: November 2020

Background:
There has been continuous advancement in technologies for past few decades by incorporating new features in accordance to the market demand. The evolution of software projects/applications has intricated debugging process by generating numerous faults in it.

Objective:
In this study, an attempt is made to develop a software reliability growth model (SRGM) taking into account the software project/application’s characteristic such as complexity of code and testing environment. The simulation is based on previous fault data in order to foresee the future latent faults occurring in the system for a given time frame. This model not only forecast the number of faults but is an extended version of Kapur and Garg’s error removal phenomenon model incorporating factors that might have influence on the model.

Methods:
The performance of the model is validated using three data sets and finally compared with extant models, namely GO model and Yamada model to assess the proposed model’s efficiency.

Results::
The parameter estimations were significant and the proposed model performed better in comparison to the other two models.

Conclusion:
The proposed model is a contribution to the studies on the reliability of the project and can be extended in future by generalizing the results over various datasets and models.
The Acceptability and Efficacy of Electronic Data Collection in a Hospital Neurodevelopmental Clinic: Pilot Questionnaire Study
Authors: Patel Shrujna , Boulton Kelsie Ann , Redoblado-Hodge Marie Antoinette , Papanicolaou Angela , Barnett Diana , Bennett Beverley , Drevensek Suzi , Cramsie Jane , Ganesalingam Kalaichelvi , Ong Natalie , Rozsa Magdalen , Sutherland Rebecca , Williamsz Marcia , Pokorski Izabella , Song Yun Ju Christine , Silove Natalie , Guastella Adam John 
Published: November 2020

Background
There is a growing need for cost-efficient and patient-centered approaches to support families in hospital- and community-based neurodevelopmental services. For such purposes, electronic data collection (EDC) may hold advantages over paper-based data collection. Such EDC approaches enable automated data collection for scoring and interpretation, saving time for clinicians and services and promoting more efficient service delivery.

Objective
This pilot study evaluated the efficacy of EDC for the Child Development Unit, a hospital-based diagnostic assessment clinic in the Sydney Children’s Hospital Network. Caregiver response rates and preference for EDC or paper-based methods were evaluated as well as the moderating role of demographic characteristics such as age, level of education, and ethnic background.

Methods
Families were sent either a paper-based questionnaire via post or an electronic mail link for completion before attending their first on-site clinic appointment for assessment. A total of 62 families were provided a paper version of the questionnaire, while 184 families were provided the online version of the same questionnaire.

Results
Completion rates of the questionnaire before the first appointment were significantly higher for EDC (164/184, 89.1%) in comparison to paper-based methods (24/62, 39%; P<.001). Within the EDC group, a vast majority of respondents indicated a preference for completing the questionnaire online (151/173, 87.3%), compared to paper completion (22/173, 12.7%; P<.001). Of the caregiver demographic characteristics, only the respondent’s level of education was associated with modality preference, such that those with a higher level of education reported a greater preference for EDC (P=.04).

Conclusions
These results show that EDC is feasible in hospital-based clinics and has the potential to offer substantial benefits in terms of centralized data collation, time and cost savings, efficiency of service, and resource allocation. The results of this study therefore support the continued use of electronic methods to improve family-centered care in clinical practices.
Citizen Responses to Government Restrictions in Switzerland During the COVID-19 Pandemic: Cross-Sectional Survey
Authors: Selby Kevin , Durand Marie-Anne , Gouveia Alexandre , Bosisio Francesca , Barazzetti Gaia , Hostettler Maxime , D'Acremont Valérie , Kaufmann Alain , von Plessen Christian 
Published: November 2020

Background
The success of government-recommended mitigation measures during the COVID-19 pandemic depends largely on information uptake and implementation by individual citizens.

Objective
Our aim was to assess citizens’ knowledge and perceptions about COVID-19 recommendations in the Canton of Vaud, Switzerland.

Methods
A cross-sectional electronic survey with open and closed questions was disseminated by community-based partners prior to the relaxation of government restrictions. Outcomes included citizen knowledge (9-question measure) and worry about the virus, perception of government measures, and recommendations for improvements. Comparisons used linear regression, controlling for age, sex, education, and health literacy. Free-text answers were analyzed thematically.

Results
Of 807 people who accessed the survey, 684 (85%) completed all questions and 479 (60%) gave free-text recommendations. Overall, 75% were female, the mean age was 48 years, and 93% had high health literacy. Knowledge scores were high, with a median score of 8 out of 9. Mean levels of worry about the COVID-19 pandemic were higher in women than men (55/100 versus 44/100, P<.001), and in respondents with lower health literacy (57/100 versus 52/100, P=.03). Self-reported adherence to recommendations was high (85%) and increased with age and worry (both P<.001). Respondents rated their own adherence higher than others (85% versus 61%, P<.001). Moreover, 34% of respondents reported having self-quarantined; this rose to 52% for those aged ≥75 years. Those who had self-quarantined reported higher levels of fear. Nearly half (49%) of respondents felt the government response had been adequate, though younger age and higher levels of worry were associated with considering the response to be insufficient (both P<.001). Analysis of open-text answers revealed 4 major themes: access to and use of masks, gloves, and hand sanitizer; government messaging; lockdown and lockdown exit plan communication; and testing for COVID-19.

Conclusions
Knowledge, adherence, and satisfaction regarding government recommendations and response were high in this sample, but many desired greater access to personal protective equipment. Those with lower health literacy and those who have been in self-isolation reported greater concerns about the pandemic.
Acciones y fundamentos del trabajo del Cuerpo Médico Escolar en el Uruguay (1907-1927). La construcción de la normalidad en los cuerpos en el magisterio
Authors: Sosa Fernanda 
Published: November 2020

En este trabajo se analiza el funcionamiento del Cuerpo Médico Escolar (CME) en el Uruguay entre 1907 y 1927 y se sostiene que uno de los ámbitos de mayor influencia de sus acciones lo constituye la construcción de normalidad en los cuerpos de maestras, maestros y estudiantes magisteriales. La normalización es un concepto foucaultiano que refiere a la regulación de los cuerpos de los individuos (disciplinas) y de las poblaciones (biopolíticas) y que orientará el análisis de las acciones del CME, particularmente las desarrolladas con estudiantes magisteriales, concursantes para cargos docentes, y en el reconocimiento anual del estado sanitario del magisterio. Las acciones llevadas adelante por el CME se fundan en argumentos que provienen del higienismo, superpuestos con argumentos propios de la eugenesia. Para este trabajo se analizaron reglamentaciones, sesiones e informes internos del Cuerpo Médico Escolar; artículos en Anales de Instrucción Primaria; Informes del CME en las Memorias de Instrucción Primaria y manuales de Anatomía, Fisiología e Higiene y de Economía Doméstica.
PENGARUH MODEL PEMBELAJARAN NUMBERED HEAD TOGETHER (NHT) TERHADAP KEMAMPUAN MENGIDENTIFIKASI STRUKTUR DAN UNSUR TEKS DRAMA SISWA KELAS XI SMA NEGERI 2 BINJAI TAHUN PEMBELAJARAN 2019/2020
Authors: Rangkuti Nabilah Ananda , Lubis Fitriani 
Published: November 2020

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Numbered Heads Together (NHT) terhadap mengidentifikasi struktur dan unsur teks drama siswa kelas XI SMA Negeri 2 Binjai tahun pembelajaran 2019/2020. Populasi penelitian ini adalah seluruh siswa kelas XI SMA Negeri 2 Binjai tahun pembelajaran 2019/2020 yang terdiri dari 12 kelas dengan jumlah 404 siswa. Sampel yang diambil adalah kelas XI PMS 6 berjumlah 30 siswa. Metode yang digunakan adalah metode penelitian kuantitatif dengan bentuk eksperimen dan penelitian deskriptif dengan tipe tes awal-tes akhir kelompok tunggal (the one group pre-test-post-test). Nilai rata-rata pre-test siswa yaitu sebesar 60,00 dengan kategori kurang dan tidak memenuhi KKM yang ditentukan pihak sekolah yaitu sebesar 75, sedangkan nilai rata-rata post-test siswa yaitu sebesar 82,77 dengan kategori baik dan telah memenuhi KKM. Berdasarkan hasil analisis, diperoleh bahwa data berdistribusi normal. Setelah dilakukan perhitungan uji normalitas Lhitung>Ltabel pada taraf signifikan, hasil uji normalitas data pre-test adalah (0,159< 0,161), hasil uji normalitas data post-test adalah (0,131< 0,161). Hasil uji homogenitas kemampuan mengidentifikasi struktur dan unsur teks drama adalah Fhitung < Ftabel yakni 3,11<4,17 dan uji hipotesis thitung > ttabel yaitu 7,87> 2,045, sehingga hipotesis nihil (H0) ditolak dan hipotesis alternatif (Ha) diterima. Jadi, dapat disimpulkan bahwa model pembelajaran Numbered Heads Together (NHT) memiliki pengaruh terhadap kemampuan mengidentifikasi struktur dan unsur teks drama siswa kelas XI SMA Negeri 2 Binjai tahun pembelajaran 2019/2020.
ANALISIS KEMAMPUAN KOGNITIF DAN SIKAP SISWA PADA MATERI SISTEM REPRODUKSI MANUSIA KELAS XI IPA SMA NEGERI 1 TANJUNG MORAWA T.P 2016/2017
Authors: Rajagukguk Jessika , Hasairin Ashar , Hutagaol Nurhayati 
Published: November 2020

This study aims to find the learning outcome and attitudes on material of humans reproductive system in grade XI IPA SMA Negeri 1 Tanjung morawa Learning Year 2016/2017. The population in this study were all students of class XI IPA which amounted to 78 people. 39 samples taken by purposive sampling in class XI IPA 5 and 39 samples from each classes were taken by purposive sampling. The datas were collected by observasion sheets were used to know students attitudes and 30 question were used to get learning outcome the student The results showed that the percentage of cognitive aspect ability was good with the average score of 72,08. This can be seen from the presentation of the complete value of 75.64% with the categories of material and unfinished presentation as much as 24.53% with less understood category. While the presentation of student attitudes is good where the material assessment consisting of the following 5 categories of assessment indicators can be elaborated as follows: presentation of attitudes value to respect as much as 80.68%, presentation of attitudes value for responsibilities of 75.08%, presentation of values Attitudes for discipline as much as 81.97%, presentation attitudes to work together as much as 70.35% and presentation of attitude values for liveliness as much as 60.81%.Keywords: cognitive aspect ability, student attitudes, human reproductive system.
PENGARUH GENIUS LEARNING STRATEGY TERHADAP KEMAMPUAN BERPIKIR TINGKAT TINGGI PADA MATERI SISTEM PERNAPASAN MANUSIA
Authors: Sirait Gloria , Djulia Ely , Sinaga Saria 
Published: November 2020

Penelitian quasi eksperimen ini bertujuan untuk mengetahui pengaruh genius learning strategy terhadap kemampuan berfikir tingkat tinggi siswa kelas VIII SMP Negeri 1 Tebing Tinggi pada materi Sistem Pernapasan Manusia T.P 2018/2019 serta mengetahui hubungan antara genius learning strategy dengan kemampuan berpikir tingkat tinggi. Sampel diambil dengan teknik Purposive Sampling yaitu siswa/i kelas VIII-7 dan VIII-8 SMP Negeri 1 Tebing Tinggi yang berjumlah 82 orang.Instrumen yang digunakan berupa tes kemampuan berpikir tingkat tinggi setiap siswa. Teknik analisis data yang digunakan adalah uji-t. Hasil penelitian dapat disimpulkan bahwa terdapat pengaruh yang signifikangenius learning strategy terhadap kemampuan berpikir tingkat tinggi dengan nilai sig 0,000< 0,05.
PENERAPAN MODEL PROBLEM BASED LEARNING UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA PEMBELAJARAN TEMA 7
Authors: Nurman Veni , Ramadhani Rizqa , Wahyugi Rahmad , Fitria Yanti , Desyandri Desyandri 
Published: November 2020

This study aimed to increase the learning outcomes by applying problem based laerning in class 4th SDN 13 IV Koto Aur Malintang. The subjects of this study amounted to 20 students. Data collection techniques used were observation, interview, and documentation. The data collected in this study were observational data of lesson plan, student and teacher activities in learning and test results. Data analysis techniques used descriptive qualitative analysis and quantitative analysis. The results of this study indicate an increase in learning outcomes. This was show from cycle I, II and III. The activities has increased compared to the pre-cycle. The results students activities meet the criteria for success of action, name ly the success of the learning process by students is said to be good, if every aspect of the observation sheet students all come up with information that has been carried out well and the average value of students is ≥ 70 and increases each cycle. Thus, the application of problem based learning can increase the learning outcomes in learning in grade IV of SDN 13 IV Koto Aur Malintang.Keywords: problem based learning, student learning outc