bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards adopting open and data‐driven science practices in bed form dynamics research, and some steps to this end
Authors: Gutierrez Ronald R. , Lefebvre Alice , Núñez‐González Francisco , Avila Humberto 
Published: January 2020

AbstractIn recent years, open and data‐driven science has fostered very important scientific breakthroughs. This study describes the challenges and opportunities for the scientific community devoted to bed form dynamics research in adopting such scientific paradigms through, for example, engineered data sharing, formal recognition of scientists who collect the data, and collaborative development of free accessible software. It highlights that once these actions are completed, the potential application of deep learning techniques could substantially improve bed form models and the scientific understanding of bed form dynamics. Likewise, it discusses the potential of Bedforms‐ATM, a free available software, to standardize some bed form data analysis techniques. We propose that the technical challenges be tackled by following scholarly accepted/proposed standards (e.g. FAIR Guiding Principles, Geoscience Papers of the Future), using the body of knowledge being built on the matter by some institutions (e.g. Federation of Earth Science Information Partners), and through technical discussions at scientific meetings such as MARID. © 2020 John Wiley & Sons, Ltd.
Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK
Authors: Sandoval‐Rodriguez Ana , Monroy‐Ramirez Hugo Christian , Meza‐Rios Alejandra , Garcia‐Bañuelos Jesus , Vera‐Cruz Jose , Gutiérrez‐Cuevas Jorge , Silva‐Gomez Jorge , Staels Bart , Dominguez‐Rosales Jose , Galicia‐Moreno Marina , Vazquez‐Del Mercado Monica , Navarro‐Partida Jose , Santos‐Garcia Arturo , Armendariz‐Borunda Juan 
Published: January 2020

Nonalcoholic steatohepatitis (NASH) is recognized by hepatic lipid accumulation, inflammation, and fibrosis. No studies have evaluated the prolonged‐release pirfenidone (PR‐PFD) properties on NASH features. The aim of this study is to evaluate how PR‐PFD performs on metabolic functions, and provide insight on a mouse model of human NASH. Male C57BL/6J mice were fed with either normo diet or high‐fat/carbohydrate diet for 16 weeks and a subgroup also fed with PR‐PFD (300 mg/kg/day). An insulin tolerance test was performed at the end of treatment. Histological analysis, determination of serum hormones, adipocytokines measurement, and evaluation of proteins by western blot was performed. Molecular docking, in silico site‐directed mutagenesis, and in vitro experiments using HepG2 cultured cells were performed to validate PR‐PFD binding to peroxisome proliferator–activated receptor alpha (PPAR‐α), activation of PPAR‐α promoter, and sirtuin 1 (SIRT1) protein expression. Compared with the high‐fat group, the PR‐PFD‐treated mice displayed less weight gain, cholesterol, very low density lipoprotein and triglycerides, and showed a significant reduction of hepatic macrosteatosis, inflammation, hepatocyte ballooning, fibrosis, epididymal fat, and total adiposity. PR‐PFD restored levels of insulin, glucagon, adiponectin, and resistin along with improved insulin resistance. Noteworthy, SIRT1–liver kinase B1–phospho‐5′ adenosine monophosphate–activated protein kinase signaling and the PPAR‐α/carnitine O‐palmitoyltransferase 1/acyl‐CoA oxidase 1 pathway were clearly induced in high fat + PR‐PFD mice. In HepG2 cells incubated with palmitate, PR‐PFD induced activation and nuclear translocation of both PPARα and SIRT1, which correlated with increased SIRT1 phosphorylated in serine 47, suggesting a positive feedback loop between the two proteins. These results were confirmed with both synthetic PPAR‐α and SIRT1 activators and inhibitors. Finally, we found that PR‐PFD is a true agonist/ligand for PPAR‐α. Conclusions: PR‐PFD provided an anti‐steatogenic effect and protection for inflammation and fibrosis.
A Dinucleating Ligand System with Varying Terminal Donors to Mimic Diiron Active Sites
Authors: Walleck Stephan , Glaser Thorsten 
Published: January 2020

AbstractTo mimic dinuclear active sites of metalloproteins, we have developed a dinucleating ligand system consisting of two tetradentate tripodal ligand compartments with varying terminal donors (carboxylates, phenolates, and pyridines). These ligands provide access to a series of μ‐oxo‐bridged diferric complexes. The spectroscopic study allows to investigate the molecular structures even in solution, e. g. depending on protonation/deprotonation of coordinated OH− and H2O ligands or to observe a reversible pH‐dependent carboxylate‐shift between terminal and bridging binding mode. The electrochemical behavior is strongly influenced by the exogenous ligands, e. g. OH− facilitates oxidation to FeIV by 690 mV relative to Cl−. Using the terminal carboxylates and a {FeIII(μ‐O)2FeIII} core even allows oxidation with O2 to a high‐valent species with FeIV (S=2). The implications of this study for further generation of high‐valent or peroxo species and their utilization in catalysis is discussed.
Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non–small‐cell lung cancer patients
Authors: Ye Qing , Zhang Min , Yin Yiping 
Published: January 2020

AbstractObjectiveThe present study aimed to investigate the correlation of katanin P80 expression with clinicopathological features and survival profile in non–small‐cell lung cancer (NSCLC) patients.MethodsTotally, 398 NSCLC patients treated by pulmonary resection were enrolled and their tumor specimens were collected to determine katanin P80 expression by immunohistochemistry (IHC) assay. Clinical data were collected at diagnosis, and survival data including disease‐free survival (DFS) and overall survival (OS) were assessed after treatment.ResultsThere were 195 (49.0%) patients with katanin P80 high expression and 203 (51.0%) patients with katanin P80 low expression, respectively. Meanwhile, katanin P80 high expression was associated with larger tumor size (P = .001), lymph node (LYN) metastasis (P = .005), and advanced TNM stage (P = .001). As for survival data, katanin P80 high expression was correlated with reduced DFS (P < .001) and OS (P < .001). And forward stepwise multivariate Cox's regression revealed that katanin P80 high expression was an independent predictor for decreased DFS (P < .001) and OS (P < .001). Besides, further analysis indicated that DFS (P < .001) and OS (P < .001) were the shortest in patients with katanin P80 high+++ expression, followed by patients with katanin P80 high++ expression and then those with katanin P80 high + expression and katanin P80 low expression.ConclusionKatanin P80 correlates with larger tumor size, LYN metastasis, and advanced TNM stage, and serves as a potential biomarker for predicting poor survival in NSCLC patients.
Up‐regulation of long non‐coding RNA THRIL in coronary heart disease: Prediction for disease risk, correlation with inflammation, coronary artery stenosis, and major adverse cardiovascular events
Authors: Qi Haijun , Shen Jie , Zhou Wenping 
Published: January 2020

AbstractObjectiveThis study aimed to investigate the role of long non‐coding RNA (lncRNA) THRIL in coronary heart disease (CHD) patients.MethodsA total of 420 patients who underwent coronary arteriography due to suspected symptoms of CHD were enrolled, in which 220 were diagnosed as CHD and 200 were set as control subjects. LncRNA THRIL in plasma samples of CHD patients and control subjects was detected by reverse transcription‐quantitative polymerase chain reaction. Gensini score and biochemical indexes were evaluated in CHD patients and control subjects. Plasma inflammatory cytokines were detected, and major adverse cardiovascular events (MACE) were recorded in CHD patients.ResultsBoth before and after adjustment by age/gender, lncRNA THRIL was increased in CHD patients compared with control subjects (both P < .001), and it well predicted enhanced CHD risk by receiver operating characteristic curves. For coronary artery stenosis, it was positively correlated with Gensini score (P < .001, r = .430). For clinical characteristics, lncRNA THRIL was positively correlated with diabetes mellitus occurrence (P < .001) and fasting blood glucose (FBG) level (P = .029, r = .147). For inflammation, it was positively associated with CRP (P < .001, r = .374), TNF‐α (P < .001, r = .249), IL‐1β (P = .001, r = .222), IL‐8 (P < .001, r = .254), and IL‐17 (P = .011, r = .172), while negatively correlated with IL‐10 (P < .001, r = −.244). For prognosis, lncRNA THRIL was positively associated with MACE accumulating rate (P = .037) in CHD patients.ConclusionLong non‐coding RNA THRIL was increased in CHD patients and well predicted elevated CHD risk. Moreover, it was correlated with enhanced coronary stenosis, systematic inflammation, FBG level, and MACE risk in CHD patients.
#4645Boricuas: Twitter reactions to the estimates of deaths by Hurricane María in Puerto Rico
Authors: García‐Ramírez Grisel M. , Bogen Katherine W. , Rodríguez‐Guzmán Von M. , Nugent Nicole , Orchowski Lindsay M. 
Published: January 2020

AbstractThis study explores the sentiment expressed by Twitter users after the Harvard University report was released, reporting a death estimate of 4,645 Puerto Ricans following Hurricane María. Researchers utilized the NVivo addition NCapture to collect Twitter data including the hashtag #4645Boricuas. Thematic content analyses explored emergent themes within the hashtag. Geographic information systems (GIS) documented the location of Tweets and differences across geographical locations among Twitter users. The themes that emerged in #4645Boricuas included: disaster phases, media, psychological processes, and politics. GIS documented that Tweets from Puerto Rico were more likely to discuss themes of psychological processes, politics, and resilience compared with disaster phases or media. The present data highlights how individuals engage with Twitter to cope following the trauma of natural disasters.
Implementation of e‐mental health for depression and anxiety: A critical scoping review
Authors: Ellis Louise A. , Augustsson Hanna , Grødahl Anne I. , Pomare Chiara , Churruca Kate , Long Janet C. , Ludlow Kristiana , Zurynski Yvonne A. , Braithwaite Jeffrey 
Published: January 2020

AbstractThe aim of this review was to scope the growth and development of implementation research of e‐mental healthcare programs for anxiety and depression, the research and evaluation tools used, and the specific implementation processes and outcomes examined. A search of four electronic databases (MEDLINE, EMBASE, PsycINFO, and CINAHL) was conducted from January 2000 to January 2019. Of 33 studies identified, most (n = 28) were published in the last five years. Only 10 used an implementation framework to guide implementation or evaluation. Most studies reported on acceptability (n = 28), appropriateness (n = 23), and feasibility (n = 17). Less commonly reported implementation outcomes were fidelity (n = 10) and adoption (n = 7); with penetration (n = 4), sustainability (n = 3), and implementation cost (n = 2) being studied rarely. Of the 21 studies that used surveys to study implementation outcomes, less than half used a previously published survey (n = 9). More rigorous implementation studies, underpinned by strong theory and real‐world understanding, are urgently needed.
CCCH-type zinc finger antiviral protein mediates antiviral immune response by activating T cells
Authors: Zhu Mingjun , Zhou Jing , Liang Yanfei , Nair Venugopal , Yao Yongxiu , Cheng Ziqiang 
Published: January 2020

Abstract
The zinc finger antiviral protein (ZAP), as a host restriction factor, inhibits the replication of certain viruses by binding viral mRNA or proteins for degradation. However, little is known about the role of ZAP in the antiviral immune response. We now show that ZAP participates in the antiviral immune response by activating T cells. Overexpression of ZAP significantly inhibited avian leukosis virus subgroup J (ALV-J) replication and reduced the associated inflammatory damage in vivo. In this study, we found that ZAP tended to be expressed in T lymphocytes, especially after ALV-J infection. T lymphocyte proliferation proceeded as usual in response to ALV-J infection in the presence of ZAP, indicating that ZAP endows T lymphocytes with resistance to the immunosuppression caused by ALV-J. Furthermore, ZAP activated cytokine secretion by T lymphocytes by contributing to nuclear translocation of nuclear factors of activated T cells and indirectly promoted anti-ALV-J antibody generation. Together, our findings show that ZAP, acting as an immunomodulatory factor, is involved in the antiviral immune response via T lymphocyte activation.
Characterization of major capsid protein (L1) variants of Human papillomavirus type 16 by cervical neoplastic status in Indian women: Phylogenetic and functional analysis
Authors: Mane Arati , Patil Linata , Limaye Sanket , Nirmalkar Amit , Kulkarni‐Kale Urmila 
Published: January 2020

AbstractThe etiological role of infection with Human papillomavirus type 16 (HPV16) in cervical cancer is well established. HPV16 variants, classified based on less than 10% nucleotide variations in the major capsid (L1 ORF) are known to contribute to persistent infection leading to cancer development. L1 protein forms the cornerstone of HPV structure and antigenicity. In the present study, HPV16 L1 variants were characterized by cervical lesion grade and variations in sequences were correlated to structure and function. The L1 gene was analyzed in 152 HPV16 positive cervical samples obtained from Indian women using polymerase chain reaction‐directed sequencing. Phylogenetic analysis was carried out for lineage typing. Sixty‐one SNPs were detected in L1 genes resulting in 20 nonsynonymous amino acid substitutions of which N56T, N92T, L158F, V178G, N181I, K236T, K443Q, K454T, and K475R are reported in Indian isolates for the first time. The substitutions N181T, T353P, and T389S were significantly associated with high‐grade cervical disease. The predominance of lineage A (A1‐A4, 84.96%) was observed among the isolates, while the D3 sublineage showed significant association with high‐grade cervical lesions. No evidence for recombination and the positive selection was obtained. These substitutions, when mapped on three‐dimensional structure, revealed that 11 and 4 substitutions are part of experimentally validated B‐ and T‐cell epitopes, of which T266A and N285T were common to both types of epitopes and may impact HPV vaccine efficacy. The variants identified through this study have the potential to serve as translational leads for designing diagnostic probes and vaccines.
More robust changes in the East Asian winter monsoon from 1.5 to 2.0°C global warming targets
Authors: Miao Jiapeng , Wang Tao , Chen Dong 
Published: January 2020

AbstractThis study investigates changes in the East Asian winter monsoon (EAWM) under 1.5 and 2.0°C global warming (1.5 and 2.0GW) targets using multi‐model results from the Coupled Model Intercomparison Project phase 5 (CMIP5). It is found that the surface air temperature increases over the Asian continent and Pacific, and the precipitation increases over the northern Asian continent in winter during the 1.5 and 2.0GW periods. For the 1.5GW period, large uncertainties can be found in the projection of EAWM system members (i.e., Siberian high, Aleutian low, low‐level winds over eastern Asia, East Asian trough [EAT] and East Asian jet stream [EAJS]). For the 2.0GW period, more than two‐thirds of the models show that the Siberian high, the EAT and the meridional shear of the EAJS are weakened, but the Aleutian low is intensified. In addition, the intensified Aleutian low enhances low‐level northwesterly wind along the coast of northeastern Asia. Compared to those in the 1.5GW period, the EAWM system members show more robust changes during the 2.0GW period, except for the low‐level winds at mid‐latitude eastern Asia. These conclusions are suitable for both the RCP4.5 and RCP8.5 scenarios.
Anionic Surfactant Impregnation in Solid Waste for Cu2+ Adsorption: Study of Kinetics, Equilibrium Isotherms, and Thermodynamic Parameters
Authors: Pinheiro Nascimento Paula F. , Barros Neto Eduardo L. , Fernandes Bezerra Diego V. , Ferreira da Silva Alfredo J. 
Published: January 2020

AbstractCoconut shell powder (CP) and diatomite (Di) were modified with microemulsion (μE), producing low‐cost adsorbents for copper (II) removal from aqueous solutions. The μE was prepared using as active phase an anionic surfactant sodium octanoate (SO), obtained from the saponification of octanoic acid. The effect of modification on the adsorption capacity of Cu+2 was evaluated taking into consideration the solution pH, equilibrium time, temperature, and initial concentration of metal in solution. The adsorbents were analyzed by characterization techniques of X‐Ray Fluorescence, scanning electron microscope and Fourier Transform Infrared Spectroscopy. The obtained experimental data were analyzed using the equations of Langmuir, Freundlich, Temkin, and Dubinin Radushkevich models. The initial concentration of 50 mg Cu+2/L solution and 0.2 g of adsorbent materials modified with the μE presented a Cu+2 removal efficiency of 86.81% and 96.3% for CP and Di, respectively. The kinetic models of pseudo first‐order, pseudo second‐order, Elovich, and intraparticle diffusion were used in this study to describe the adsorption rate. The presence of sodium octanoate functional (OS) group provided ion exchange sites suitable to Cu+2 adsorption. The stability of the OS impregnation using microemulsion was evaluated based on a desorption study.
Synthesis and Properties of pH‐Dependent Gemini Surfactants Containing Multiple Carboxyl Groups
Authors: Qiao Longyin , Zhang Wanjing , Xu Libo , Han Fu , Zhou Yawen , Xu Baocai 
Published: January 2020

AbstractA series of Gemini surfactants N,N″‐dialkyl‐N,N′,N″‐tripropionate diethylenetriamine (referred as DTPDT‐n, where n is the length of the hydrocarbon chain, n = 10, 12, 14) were synthesized, which have three carboxylic head‐groups and two hydrophobic alkane chains. The products were characterized by means of nuclear magnetic resonance and mass spectrometry. The physicochemical properties of DTPDT‐n surfactants with different hydrocarbon chain lengths were studied such as isoelectric point, surface activities, emulsifying properties, and foam properties. It is showed that these compounds exhibit pH‐dependent protonation‐deprotonation behavior. The isoelectric points of DTPDT‐n surfactants are between 3.40 and 10.90. The critical micellar concentration (cmc) of all three surfactants are lower than the corresponding monomeric surfactants (single head group, single‐chain), especially DTPDT‐14, whose cmc can reach 2.29 × 10−5 mol/L. With an increase in the length of the alkyl chain, the solubility of the surfactants decreases and the surface tension of the three surfactants at cmc increases. In consideration of pH, all of three surfactants appear better emulsifying capacity and foaming property under weak alkaline conditions. DTPDT‐14 has the best performance of emulsifying capacity among the three surfactants. DTPDT‐10 has excellent foaming ability and foam stability.
Transvaginal Ultrasound and Doppler Features of Intraligamental Myomas
Authors: Ambrosio Marco , Raimondo Diego , Savelli Luca , Salucci Paolo , Arena Alessandro , Borghese Giulia , Mattioli Giulia , Giaquinto Ilaria , Scifo Maria Cristina , Meriggiola Maria Cristina , Casadio Paolo , Seracchioli Renato 
Published: January 2020

ObjectivesTo describe the ultrasound (US) features of intraligamental myomas (IMs) using Morphological Uterus Sonographic Assessment group standardized terminology.MethodsThis was a retrospective monocentric study. A total of 125 consecutive women with a preoperative US diagnosis of a myoma located close to the uterine isthmus (International Federation of Gynecology and Obstetrics stages 5, 6, and 7) from 2016 to 2019 who underwent laparoscopic or laparotomic myomectomy or hysterectomy were included for study analyses. The US data were retrieved from US reports and stored digital images by 2 authors. Ultrasound features of myomas were described according to Morphological Uterus Sonographic Assessment terminology. Clinical data for the study population were retrieved from the patients’ records.ResultsNineteen women with a surgical confirmation of an IM were included in the study group; the remaining population constituted the control group (n = 106). Non‐uniform echogenicity was detected in 17 of 19 (89%) of IMs compared to 26 of 106 (25%) fibroids in the control group (P < .001). The presence of shadowing was detected in 12 of 19 (63%) IMs compared to 94 of 106 (89%) cases in the control group (P = .004). Intraligamental myomas were more vascularized tumors compared to myomas in the control group (P = .004). Transvaginal US showed high specificity for the diagnosis of an IM (0.93; 95% confidence interval, 0.87–0.96).ConclusionsOn US imaging, IMs appear as vascularized solid tumors with nonuniform echogenicity; cones of shadows were less frequent in IMs than the control group, and this finding can help in the differential diagnosis. Knowledge of their specific US features could help sonographers make an accurate diagnosis, allowing them to plan correct surgery and avoid severe complications.
An amino‐based protic ionic liquid as a corrosion inhibitor of mild steel in aqueous chloride solutions
Authors: Schmitzhaus Tobias Eduardo , Ortega Vega Maria R. , Schroeder Roberto , Muller Iduvirges Lourdes , Mattedi Silvana , Malfatti Célia de Fraga 
Published: January 2020

AbstractProtic ionic liquids (PILs) have shown to be promising substances as corrosion inhibitors (CIs). In line with this, the aim of this study is to study the performance and propose the corrosion inhibition mechanism of N‐methyl‐2‐hydroxyethylamine (M‐2HEAOL) and bis‐2‐hidroxyethylamine (B‐HEAOL) oleate, for mild steel, in a neutral chloride solution. Electrochemical characterization was conducted under static and hydrodynamic conditions, and it was revealed that M‐2HEAOL and B‐HEAOL worked as mixed‐type CIs with more interference on the anodic reaction. Inhibition efficiency depended on the concentration reaching 97% of inhibition efficiency in 5 mmol/L concentration. Scanning electron microscopy, optical interferometry, Raman spectroscopy, and Fourier‐transform infrared spectroscopy are used to elicit the chemical composition of the surface film and corrosion morphology of steel in the presence of CIs, the adsorption processes of which involved physical and chemical adsorption between metal and different parts of ionic liquids. The results allowed the proposition of a corrosion inhibition mechanism.