bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of personalized and precision medicine: Pharmacometabolomic applications to rare cancer, microbiological investigation, and therapy
Authors: Cristoni Simone , Bernardi Luigi Rossi , Malvandi Amir Mohammad , Larini Martina , Longhi Ermanno , Sortino Francesco , Conti Matteo , Pantano Nicola , Puccio Giovanni 
Published: October 2020

RationaleAdvances in metabolomics, together with consolidated genetic approaches, have opened the way for investigating the health of patients using a large number of molecules simultaneously, thus providing firm scientific evidence for personalized medicine and consequent interventions. Metabolomics is an ideal approach for investigating specific biochemical alterations occurring in rare clinical situations, such as those caused by rare associations between comorbidities and immunosuppression.MethodsMetabolomic database matching enables clear identification of molecular factors associated with a metabolic disorder and can provide a rationale for elaborating personalized therapeutic protocols. Mass spectrometry (MS) forms the basis of metabolomics and uses mass‐to‐charge ratios for metabolite identification. Here, we used an MS–based approach to diagnose and develop treatment options in the clinical case of a patient afflicted with a rare disease further complicated by immunosuppression. The patient's data were analyzed using proprietary databases, and a personalized and efficient therapeutic protocol was consequently elaborated.ResultsThe patient exhibited significant alterations in homocysteine:methionine and homocysteine:thiodiglycol acid plasma concentration ratios, and these were associated with low immune system function. This led to cysteine concentration deficiency causing extreme oxidative stress. Plasmatic thioglycolic acid concentrations were initially altered and were used for therapeutic follow‐up and to evaluate cysteine levels.ConclusionsAn MS–based pharmacometabolomics approach was used to define a personalized protocol in a clinical case of rare peritoneal carcinosis with confounding immunosuppression. This personalized protocol reduced both oxidative stress and resistance to antibiotics and antiviral drugs.
An active endoscope with small sweep volume that preserves image orientation for arthroscopic surgery
Authors: Ryu Geunwoong , Kim Jeongryul , Park Chulmin , Kim Keri 
Published: October 2020

AbstractBackgroundMicrosurgery is generally performed in narrow spaces with limited movement. Endoscopes that allow for angle changes have been developed using elastic materials, but they require a large bending space. We propose a new endoscope with a small sweep volume for angle changes.MethodsWe fabricated a prototype with a thumb‐operated joystick. The image sensor is attached to the tooltip. The image signal is input to a motor control board which computes inverse kinematics and transforms it into joint angle values. Each axis is positioned according to these values.ResultsThe tooltip sweeping volume was 104 mm3. Surgeons at the Asan Medical Center used our endoscope to obtain images of the biceps tendon and subscapularis joints of a cadaver.ConclusionCurrently, a low‐resolution image sensor is attached to endoscope tooltips. In the future, we will develop a high‐resolution image module equipped with an ultra‐small complementary metal oxide semiconductor sensor.
Pluripotent stem cell-based screening identifies CUDC-907 as an effective compound for restoring the in vitro phenotype of Nakajo-Nishimura syndrome
Authors: Kase Naoya , Terashima Madoka , Ohta Akira , Niwa Akira , Honda-Ozaki Fumiko , Kawasaki Yuri , Nakahata Tatsutoshi , Kanazawa Nobuo , Saito Megumu K. 
Published: October 2020

Abstract
Nakajo-Nishimura syndrome (NNS) is an autoinflammatory disorder caused by a homozygous mutations in the PSMB8 gene. The administration of systemic corticosteroids is partially effective, but continuous treatment causes severe side effects. We previously established a pluripotent stem cell (PSC)-derived NNS disease model that reproduces several inflammatory phenotypes, including the overproduction of monocyte chemoattractant protein-1 (MCP-1) and interferon gamma-induced protein-10 (IP-10). Here we performed high-throughput compound screening (HTS) using this PSC-derived NNS model to find potential therapeutic candidates and identified CUDC-907 as an effective inhibitor of the release of MCP-1 and IP-10. Short-term treatment of CUDC-907 did not induce cell death within therapeutic concentrations and was also effective on primary patient cells. Further analysis indicated that the inhibitory effect was post-transcriptional. These findings suggest that HTS with PSC-derived disease models is useful for finding drug candidates for autoinflammatory diseases.
Improved Stability and Photothermal Performance of Polydopamine‐Modified Fe3O4 Nanocomposites for Highly Efficient Magnetic Resonance Imaging‐Guided Photothermal Therapy
Authors: Li Bo , Gong Tingting , Xu Nannan , Cui Fengzhi , Yuan Biying , Yuan Qinghai , Sun Hongzan , Wang Lei , Liu Jianhua 
Published: October 2020

AbstractMagnetic nanomaterials are a promising class of contrast agents for magnetic resonance imaging (MRI). However, their poor stability and low relaxivity are major challenges hindering their clinical applications. In this study, magnetic theranostic nanoagents based on polydopamine‐modified Fe3O4 (Fe3O4@PDA) nanocomposites are fabricated for MRI‐guided photothermal therapy (PTT) cancer treatments. Their high transverse relaxivity of 337.8 mM−1 s−1 makes these Fe3O4@PDA nanocomposites a promising T2‐weighted MRI contrast agent for cancer diagnosis and image‐guided cancer therapy. Due to the good photothermal effect of polydopamine (PDA), the tumors of 4T1 tumor‐bearing mice are completely excised by PTT. Most importantly, the PDA shell also improves the stability of the Fe3O4@PDA nanocomposites, which contributes to their excellent, long‐term performance in MRI and PTT applications. Their good stability, high T2 relaxivity, robust biocompatibility, and satisfactory treatment effect give these Fe3O4@PDA nanocomposites great potential for use in cancer theranostics.
Predicting change in newly created files in a software product line project
Authors: Alshehri Yasser Ali 
Published: October 2020

AbstractAt the beginning of the testing phase and before the deployment phase of a project's development cycle, we need to predict files with a high chance of change. Software products are always prone to change due to several reasons, including fixing errors or improvements. In this work, we used the Eclipse (releases from 2.0 to 3.5) to investigate how prediction models can perform when learning from a release and predicting in the subsequent one, which contains new files that models have not seen. We compared the performance of these models with models that are trained and tested on the same release. We found no differences between predicting the same release or subsequent release on two pre Europa releases. Predicting change in newly created files helps improve maintenance planning for software project managers and reduce cost. It will also help to enhance the quality of software by improving the practices of developers. This study used the Adaptive Boost classifier with the decision tree J48 algorithm and combined it with the re‐sampling method. We find this to be better than using a meta classifier alone or combine the re‐sampling with the standard classification. We compared our results with related works and found that our results are outperforming.
Benzo[a]pyrene exposure and overcrowding stress impacts anxiety‐like behavior and impairs learning and memory in adult zebrafish, Danio rerio
Authors: Aparna Sai , Patri Manorama 
Published: October 2020

AbstractBenzo[a]pyrene (B[a]P), a prototype of polycyclic aromatic hydrocarbons and ubiquitous environmental pollutant, alters neurobehavioral responses in aquatic organisms like zebrafish. Increasing organic load on water bodies causes population explosion leading to overcrowding (OC) stress. The effect of OC stress on neurobehavioral alterations remains unclear. The objective of our study is to elucidate the impact of OC stress on behavioral alterations and neurodegenerative phenotypes on exposure to B[a]P in zebrafish. We demonstrate the effects of OC stress (12 fish/L) on acute waterborne exposure to B[a]P (0.2 mg L−1) in adult wild zebrafish. Anxiety‐like behavior, learning, and memory impairment were assayed by novel tank diving test, light/dark preference test, and T‐maze test. Oxidative stress bio‐markers were assayed along with histopathological changes in zebrafish brain. OC stress significantly impaired the learning ability and mood behavior by increasing the number of transition and time spent in the alter zones. Increased lipid peroxidation and protein carbonyl formation with significant decreased catalase activity and reduced glutathione level showed oxidative stress on exposure to OC stress and B[a]P. Pyknotic neuronal counts dramatically increased in periventricular grey zone of optic tectum brain region of zebrafish. Our findings showed that OC stress modulates the B[a]P‐induced behavioral alterations causing learning and memory deficiency with histopathological changes in adult zebrafish brain. OC stress may act as an early risk factor for the eventual development of cognitive impairments and B[a]P exposure plays a key role in mediating both the facilitating and impairing actions of OC stress in memory processes.
Truthfulness and Affect via Digital Mediation in Audiovisual Storytelling
Authors: Tseng Chiao-I 
Published: October 2020

AbstractThis chapter investigates different ways in which the film techniques of digitally mediated images—such as found footage, diegetic camera, and computer screen—achieve story truthfulness and affective engagement in the viewer’s narrative interpretation process. The pursuit of truthful storytelling is to demonstrate objective facts, while mediated images in film are predominantly subjective. The chapter starts by reviewing the perennial paradox of two seemingly mutually exclusive narrative functions and then tackles the paradox by proposing a multi-leveled framework, synthesizing semiotic conceptualization and cognitive research findings. It also analyzes the various forms of digital mediated images in films over the last two decades and sheds light on how the functions of truthfulness and affective engagement can be closely intertwined rather than in conflict.
Language in Digital Motion: From ABCs to Intermediality and Why This Matters for Language Learning
Authors: Lotherington Heather 
Published: October 2020

AbstractLinguistic communication has moved beyond simple alphabetic encoding to multimedia design, challenging the fit of structural theories of language to digital communication. This transition is barely evident in mobile language learning contexts where top-selling apps present language as a linguistic structure to be drilled, ironically bypassing the complex communicative potential of smart devices. This chapter overviews changing language norms from language as structure to language within multimodality and comparatively discusses multimodality from a social semiotics paradigm nested in linguistic theory and from Elleström’s intermediality paradigm. To illustrate how one could conceptualize multimodality from a perspective decentred from linguistics and leveraged to explain language use in multimedia contexts, the author examines two novel features of digital communication:emojiandconversational digital agents.
The New Trend: The Word Plus the Image
Authors: Pae Hye K. 
Published: October 2020

AbstractThis chapter discusses the new trend of co-use of words and images in digitally-mediated text as well as its impact on our cognition. The function of the left and right hemispheres of the brain is first reviewed. Next, how images are processed, compared to words, is reviewed. Reading words recruits different neural networks than those of “reading” images. Literacy acquisition changes neuronal pathways in the brain, as evidenced by the research findings of pre-literate and literate subjects. Based on the suggestive evidence, script relativity is revisited and highlighted. Research evidence from the comparison of image processing and word processing as well as the comparison of how literate and illiterate subjects process objects and faces indirectly supportscript relativity.
Neurolinguistic Evidence for Script Relativity
Authors: Pae Hye K. 
Published: October 2020

Abstract
This chapter reviews a vast amount of neuroimaging studies of Chinese, Japanese, and Korean in comparison to L2 English, using the neuonral recycling hypothesis (Dehaene, 2009) and the (writing) system accommodation hypothesis (Perfetti & Liu, 2005) as theoretical frameworks. In order to understand the basic brain network associated with reading, the major reading circuits found among typical readers are first reviewed. The findings of neuroimaging studies of reading in alphabetic scripts are reviewed and then moved on to the nonalphabetic Chinese and Japanese scripts, compared to L2 English. Although reviewed studies were not carried out to directly test script relativity, evidence converges on biological unity, script diversity, and cognitive diversity, which points toward script relativity.
Simple model for large CP violation in charm decays, B-physics anomalies, muon g − 2 and dark matter
Authors: Calibbi Lorenzo , Li Tianjun , Li Ying , Zhu Bin 
Published: October 2020

Abstract
We present a minimal extension of the Standard Model that can simultaneously account for the anomalies in semi-leptonic B meson decays and the muon g − 2, give large CP violation in charm decays (up to the value recently measured by LHCb), and provide thermal-relic dark matter, while evading all constraints set by other flavour observables, LHC searches, and dark matter experiments. This is achieved by introducing only four new fields: a vectorlike quark, a vectorlike lepton, and two scalar fields (a singlet and a doublet) that mix due to the electroweak symmetry breaking and provide the dark matter candidate. The singlet-doublet mixing induces chirally-enhanced dipole transitions, which are crucial for the explanation of the muon g − 2 discrepancy and the large charm CP violation, and allows to achieve the observed dark matter density in wide regions of the parameter space.
Collapsing domain walls in the two-Higgs-doublet model and deep insights from the EDM
Authors: Chen Ning , Li Tong , Teng Zhaolong , Wu Yongcheng 
Published: October 2020

Abstract
We study the domain wall solutions in the general two-Higgs-doublet model (2HDM) with a CP-violating phase. The 2HDM with the spontaneouse CP violation is found to have domain wall solutions whose tensions are $$ \mathcal{O} $$
O
(106) GeV3, which are excluded by the Zel’dovich-Kobzarev-Okun bound. With the explicit CP-violating (CPV) terms as the so-called biased term in the scalar potential, domain walls can collapse in the early Universe. The sizes of the explicit CP violation can be constrained from the Big Bang nucleosynthesis. This constraint is converted to the CPV mixing of αc, and is mostly sensitive to the mass splittings between two heavy neutral Higgs bosons. We estimate the possible gravitational wave signals and the electric dipole moment (EDM) predictions due to the domain wall collapsing. It turns out that the peak spectrum of the GW from the domain wall collapsing cannot be probed in any future program. In contrast, the untenable regions with very tiny explicit CPV parameter in the Higgs potential has been partially excluded by the latest electron EDM measurements at the ACME-II and will be further confirmed or excluded by the future ACME-III projection.
Asymptotic symmetries of Yang-Mills fields in Hamiltonian formulation
Authors: Tanzi Roberto , Giulini Domenico 
Published: October 2020

Abstract
We investigate the asymptotic symmetry group of the free SU(N )-Yang-Mills theory using the Hamiltonian formalism. We closely follow the strategy of Henneaux and Troessaert who successfully applied the Hamiltonian formalism to the case of gravity and electrodynamics, thereby deriving the respective asymptotic symmetry groups of these theories from clear-cut first principles. These principles include the minimal assumptions that are necessary to ensure the existence of Hamiltonian structures (phase space, symplectic form, differentiable Hamiltonian) and, in case of Poincaré invariant theories, a canonical action of the Poincaré group. In the first part of the paper we show how these requirements can be met in the non-abelian SU(N )-Yang-Mills case by imposing suitable fall-off and parity conditions on the fields. We observe that these conditions admit neither non-trivial asymptotic symmetries nor non-zero global charges. In the second part of the paper we discuss possible gradual relaxations of these conditions by following the same strategy that Henneaux and Troessaert had employed to remedy a similar situation in the electromagnetic case. Contrary to our expectation and the findings of Henneaux and Troessaert for the abelian case, there seems to be no relaxation that meets the requirements of a Hamiltonian formalism and allows for non-trivial asymptotic symmetries and charges. Non-trivial asymptotic symmetries and charges are only possible if either the Poincaré group fails to act canonically or if the formal expression for the symplectic form diverges, i.e. the form does not exist. This seems to hint at a kind of colour-confinement built into the classical Hamiltonian formulation of non-abelian gauge theories.
Investigations on the Triboelectrostatic Charging Behaviour and the Triboelectrostatic Sortability of Different Oxides
Authors: Gehringer Sabrina , Luckeneder Christoph , Flachberger Helmut 
Published: October 2020

AbstractIn the course of this study, several test series were carried out to investigate the triboelectrostatic charging behaviour of various oxides. At the beginning, the influence of the degree of aging and the influence of the sample storage on the charging efficiency of the oxide samples was analysed. For this purpose, two oxide samples were stored under different environmental conditions and then sorted using triboelectrostatic belt separation. Results of a previous series of tests showed that an increased feed temperature has a negative effect on the charging behaviour of calcium and magnesium oxide. Therefore, the effects of a reduced feed temperature were also examined. For these experiments, samples were stored at 8 °C under exclusion of air. In addition, a series of tests was carried out with a gradual increase of the voltage on the triboelectrostatic belt separator in order to determine possible differences in the charging efficiency of calcium oxide and magnesium oxide and to subsequently use them for the separation.
Effect of Statin Therapy on the Plasma Concentrations of Retinol, Alpha-Tocopherol and Coenzyme Q10 in Children with Familial Hypercholesterolemia
Authors: Motkowski Radosław , Maciejczyk Mateusz , Hryniewicka Marta , Karpińska Joanna , Mikołuć Bożena 
Published: October 2020

AbstractPurposeFamilial hypercholesterolemia (FH) requires early treatment. However, statins, which are regarded the first-line therapy, have an influence on redox balance. Antioxidant vitamins are important for many metabolic processes in the developing body. There are few data available on the long-term safety of statin use in children. The aim of this study was to evaluate the influence of statin treatment in children with FH on plasma concentrations of antioxidant vitamins: retinol, alpha-tocopherol and coenzyme Q10.MethodsThe first study group consisted of 13 children aged 10–18 years treated with simvastatin for at least 6 months, and the second group comprised 13 age- and sex-matched children with hypercholesterolemia, in whom pharmacological treatment had not been applied yet. Analyses were performed using a high-performance liquid chromatograph coupled with a MS detector.ResultsThe analysis did not reveal significant differences in the concentration of retinol, alpha-tocopherol or coenzyme Q10 between the studied groups. The adjustment of the concentrations of the vitamins to the cholesterol level also indicated no significant differences. We found no deficits in antioxidant vitamins in patients treated with statins, or any risk of adverse effects associated with an increase in their concentration.ConclusionThere is no rationale for additional supplementation using antioxidant vitamins or modification of low-fat and low-cholesterol diet in pediatric patients treated with statins.
Improvement in early continence after introduction of periurethral suspension stitch in robotic prostatectomy
Authors: Aarsæther Erling , Roaldsen Marius , Knutsen Tore , Patel Hiten R. , Soltun Bård 
Published: October 2020

AbstractEarly urinary incontinence remains a major source of morbidity for patients undergoing robotic prostatectomy. The purpose of the study was to determine whether the introduction of a suspension stitch would improve early urinary continence rates in patients undergoing robotic prostatectomy for localized prostate cancer at our department. We retrospectively reviewed patients undergoing robotic prostatectomy with either suspension (n = 119) or figure-of-eight (n = 48) stitching of the dorsal venous complex. The patients submitted EPIC-26 questionnaires before surgery and after 3 and 18 months, respectively. Logistic regression analysis was run to determine the effect of the suspension stitch, nerve-sparing, posterior reconstruction, prostate volume, age and body mass index on early continence rate. The odds ratio of experiencing urinary leaks was 2.1 times higher (95% CI 1.0–4.3) in the figure-of-eight stitch group compared to the suspension stitch group 3 months after surgery (p < 0.05). The early urinary continence rate was 61.3% in the suspension stitch group compared to 35.4% in the figure-of-eight stitch group (p < 0.005). There were no differences between the groups 18 months post-prostatectomy (90.7% in the suspension stitch group versus 81.4% in the non-suspension stitch group, p = 0.1). Ordinal regression analysis identified the suspension stitch, bilateral nerve-sparing and body mass index as independent predictors of urinary continence at 3 months. The association between urinary continence and either unilateral nerve-sparing, posterior reconstruction, prostate volume or age did not reach statistical significance. Our results suggest that the suspension stitch improved early urinary continence following robotic prostatectomy.