bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher economic education as the basis of a new quality of management of the agro-industrial complex of the Far East
Authors: Latkin A P , Gorlov A V 
Published: August 2020

Abstract
The article analyzes the current state of higher economic education in the Russian Far East. The system of training economic specialists is considered in the context of the goals and objectives of state policy for the development of the Far Eastern Federal District. The features of the distribution of students in universities in the context of regions, levels and areas of training are revealed. Based on many years of studying the problems of developing economic education, the authors give suggestions for improving the efficiency of the system of training highly qualified personnel for the needs of the region’s agro-industrial complex.
Effect of growing conditions on the formation of reproductive organs in soybean varieties with different maturity dates
Authors: Sinegovskaia V T , Ochkurova V V , Boiarskii B S 
Published: August 2020

Abstract
The influence of sowing methods on the process of formation of reproductive organs was studied on new soybean varieties Sentyabrinka, Kitrossa, Kruzhevniza in the conditions of the Amur Region. Generally, the methods of sowing with different row spacing widths are applied individually for each soybean variety. Choosing unfavorable methods can lead to low yields and a lack of seed quality. The development of cultivation technologies is required for each cultivar with individual morphological and biological features, which leads to the need for research in this direction. One of the reasons for low soybean yield is abortion during flowering, the formation of pods and seeds. We aim to study the process of the formation of reproductive organs in Amur Region soybean varieties of a new generation, depending on the availability of nutritional area in soil due to the method of sowing. With a wide-row method of sowing, more favorable conditions are formed for the growth and development of plants, which is confirmed by the yield.
Ecological variability of the quality of oats varieties depending on vegetation conditions
Authors: Trifuntova I B 
Published: August 2020

Abstract
Studies were conducted on the environmental variability of the quality of oat varieties depending on the growing conditions in the Khabarovsk territory (Russia). In recent years, the demand for high-quality oat grain has increased. The conditions for cultivating grain crops in the same soil and climate zone are very diverse. The research was aimed at studying the influence of the environment during the growing season on the quality of oats. It was noted that the most affected indicators were grain filminess (coefficient of variation (CV) is 16.8%) and the content of lysine in the grain (CV is 18.8%). To an average extent, the conditions of the year affect the characteristics of the protein content in the grain (CV is 10.1%) and the nature of the grain (CV is 14.5%), which is determined by the ecological fitness of oat varieties when cultivated in the region. The low variability of the 1000 grain weight trait (CV is 9.4%) indicates a weak response of oat genotypes to changes in environmental conditions. Based on a set of quality indicators, the varieties of oats Marshal, Cardinal and Peredovik. The Marshall oats variety was characterized by a high and stable protein and lysine content. In the variety Peredovik, a high mass of 1000 grains and a full grain weight were noted. Over the years of research, the Cardinal oat variety had a low pitting and a large mass of 1000 grains. We recommend them for sustainable crops of high-quality grain for various food uses. These varieties of oats are recommended for cultivation in the Khabarovsk Territory.
Information support for strategic management processes’ in geoecology and agriculture
Authors: Turkov S L 
Published: August 2020

Abstract
The report discusses the current situation in the field of information support in solving the problems of sustainable development of regions in their application to the field of knowledge in geoecology and agriculture. The basis for such a combination of these areas of practical activity is their structural unity in the original object of study. The purpose of the research is to develop “human-machine” systems for making optimal management decisions in the field of strategic management of sustainable development processes of territories at the global, regional and local levels of the organization. Object of research: active, including “dissipative”, complex organized systems of the class “nature” – “society”. The starting points of the methodology and management theory are the following concepts: unified Field Theory (late XX century), new “Scientific revolutions” and “Sustainable development of regions”; the leading scientific methods are “noospheric” and “geosystem” approaches. The research results and their practical significance lead to the conclusion that it is necessary to move from differentiation of all available knowledge about Nature and Society to their full integration.
Safety Guidelines Concerning the Use of Protective Eyewear and Gauze During Laser Procedures
Authors: Wamsley Christine E , Hoopman John , Kenkel Jeffrey M 
Published: August 2020

Abstract
The advancement of laser technology has seen its use gain popularity across a wide range of specialties to treat diseases, as well as address aesthetic concerns. In order to protect both the patient and the healthcare personnel providing treatment, instruction and knowledge of laser safety remain of utmost importance. In this paper, we discuss the classification of laser systems, review ocular injuries that may be caused by inappropriate laser exposure, and provide background on laser protective eyewear. In addition, we highlight the current recommendations for proper eyewear during laser use outlined in the American National Standards Institute standard Z136.3, Safe Use of Lasers in Health Care. Finally, although it is common in some healthcare facilities to place gauze under external eye shields or use gauze alone over eyes during laser procedures, this practice poses an extreme risk to both patients and healthcare personnel. Therefore, we discuss why the use of gauze under eyewear for any laser procedures is not recommended, and instead, offer suggestions to consider when acquiring safe and comfortable patient eyewear.
The performance of permutations and exponential random graph models when analyzing animal networks
Authors: Evans Julian C , Fisher David N , Silk Matthew J 
Published: August 2020

Abstract
Social network analysis is a suite of approaches for exploring relational data. Two approaches commonly used to analyze animal social network data are permutation-based tests of significance and exponential random graph models. However, the performance of these approaches when analyzing different types of network data has not been simultaneously evaluated. Here we test both approaches to determine their performance when analyzing a range of biologically realistic simulated animal social networks. We examined the false positive and false negative error rate of an effect of a two-level explanatory variable (e.g., sex) on the number and combined strength of an individual’s network connections. We measured error rates for two types of simulated data collection methods in a range of network structures, and with/without a confounding effect and missing observations. Both methods performed consistently well in networks of dyadic interactions, and worse on networks constructed using observations of individuals in groups. Exponential random graph models had a marginally lower rate of false positives than permutations in most cases. Phenotypic assortativity had a large influence on the false positive rate, and a smaller effect on the false negative rate for both methods in all network types. Aspects of within- and between-group network structure influenced error rates, but not to the same extent. In "grouping event-based" networks, increased sampling effort marginally decreased rates of false negatives, but increased rates of false positives for both analysis methods. These results provide guidelines for biologists analyzing and interpreting their own network data using these methods.
GraphQA: protein model quality assessment using graph convolutional networks
Authors: Baldassarre Federico , Menéndez Hurtado David , Elofsson Arne , Azizpour Hossein 
Published: August 2020

Abstract

Motivation
Proteins are ubiquitous molecules whose function in biological processes is determined by their 3D structure. Experimental identification of a protein’s structure can be time-consuming, prohibitively expensive and not always possible. Alternatively, protein folding can be modeled using computational methods, which however are not guaranteed to always produce optimal results. GraphQA is a graph-based method to estimate the quality of protein models, that possesses favorable properties such as representation learning, explicit modeling of both sequential and 3D structure, geometric invariance and computational efficiency.

Results
GraphQA performs similarly to state-of-the-art methods despite using a relatively low number of input features. In addition, the graph network structure provides an improvement over the architecture used in ProQ4 operating on the same input features. Finally, the individual contributions of GraphQA components are carefully evaluated.

Availability and implementation
PyTorch implementation, datasets, experiments and link to an evaluation server are available through this GitHub repository: github.com/baldassarreFe/graphqa.

Supplementary information
Supplementary data are available at Bioinformatics online.
Double atrioventricular valve replacement using Melody™ transcatheter valves in an infant with unbalanced atrioventricular septal defect: a case report
Authors: Kahl Béatrice Susanne , Michel-Behnke Ina , Zimpfer Daniel 
Published: August 2020

Abstract

Background
To the best of our knowledge, this is the first report of a successful one-stage double atrioventricular valve (AVV) replacement using two Melody™ transcatheter valves in an infant.

Case summary
We report a successful case of double AVV replacement with Melody™ transcatheter valves in a 9-month-old infant with a right ventricular dominant atrioventricular septal defect (AVSD). The boy initially presented with borderline sized left-sided heart structures, congenital left AVV stenosis, ventricular displacement of the right AVV with high-grade insufficiency and moderate valvar pulmonary stenosis. Double AVV replacement was performed 2 months after an unsuccessful attempt to repair the defect with persisting left AVV stenosis, underfilling of the small left ventricle and high-grade right AVV, and pulmonary valve regurgitation, resulting in low cardiac output. During double Melody™ AVV replacement, the right ventricular outflow tract was replaced with a pulmonary homograft. The boy was discharged on post-operative Day 28 and presented with competent valves, no ventricular outflow tract obstruction and no paravalvular leak at 11 months of follow-up.

Discussion
The presented innovative approach allowed for biventricular correction of an unbalanced AVSD with unfavourable anatomy for standard techniques. The heart team should decide individualized, after careful assessment of cardiac anatomy and function, if the benefits of replacement of AVVs with Melody™ transcatheter valves may outweigh the benefits of univentricular palliation in case of unbalanced AVSD.
Pseudohyphal differentiation inKomagataella phaffii: investigating theFLOgene family
Authors: De Sonakshi , Rebnegger Corinna , Moser Josef , Tatto Nadine , Graf Alexandra B , Mattanovich Diethard , Gasser Brigitte 
Published: August 2020

ABSTRACTMany yeasts differentiate into multicellular phenotypes in adverse environmental conditions. Here, we investigate pseudohyphal growth in Komagataella phaffii and the involvement of the flocculin (FLO) gene family in its regulation. The K. phaffii FLO family consists of 13 members, and the conditions inducing pseudohyphal growth are different from Saccharomyces cerevisiae. So far, this phenotype was only observed when K. phaffii was cultivated at slow growth rates in glucose-limited chemostats, but not upon nitrogen starvation or the presence of fusel alcohols. Transcriptional analysis identified that FLO11, FLO400 and FLO5-1 are involved in the phenotype, all being controlled by the transcriptional regulator Flo8. The three genes exhibit a complex mechanism of expression and repression during transition from yeast to pseudohyphal form. Unlike in S. cerevisiae, deletion of FLO11 does not completely prevent the phenotype. In contrast, deletion of FLO400 or FLO5-1 prevents pseudohyphae formation, and hampers FLO11 expression. FAIRE-Seq data shows that the expression and repression of FLO400 and FLO5-1 are correlated to open or closed chromatin regions upstream of these genes, respectively. Our findings indicate that K. phaffii Flo400 and/or Flo5-1 act as upstream signals that lead to the induction of FLO11 upon glucose limitation in chemostats at slow growth and chromatin modulation is involved in the regulation of their expression.
Robotic Pet Use Among Community-Dwelling Older Adults
Authors: Hudson Janella , Ungar Rachel , Albright Laurie , Tkatch Rifky , Schaeffer James , Wicker Ellen R 
Published: August 2020

Abstract

Objective
The primary purpose of this study was to explore the efficacy of robotic pets in alleviating loneliness for older adults.

Method
Self-reported lonely individuals with AARP Medicare Supplement plans insured by UnitedHealthcare who participated in a program with a robotic pet (n = 20) were recruited to participate in semi-structured interviews. Participants were asked to provide feedback about their experiences interacting with a robotic pet, their perceptions about the potential impact on loneliness, and recommendations for improving the program. Interviews were audio-recorded and transcribed verbatim. Participants’ responses were analyzed using qualitative content analysis. Constant comparison and consensus-gaining processes were used to develop categories that later formed representative themes.

Results
Seven themes emerged from analysis: Openness to Adoption of Robotic Pet, Reactions to Pet and its Attributes, Integration of Pet in Daily Life, Strategic Utilization and Forging New Connections, Deriving Comfort and Camaraderie, Advice for Future Users, and Recommendations for Enhancing Ownership Experience. Participants living alone, with fewer social connections and less active lifestyles, derived the most benefit from interacting with their pets. Common responses to pets included cuddling, petting, grooming, and sleeping with them. Some shared or loaned their pets, while others refused to loan their pets to interested peers. Most reported showing their pets to others, which helped some facilitate communication and social connections.

Conclusion
Robotic pets may be an effective solution for alleviating loneliness in older adults, especially among those who live alone, have fewer social connections, and live less active lifestyles.
Study on roof-mounted radiant cooling system for LNG-fueled refrigerated vehicles
Authors: Wang Fang , Li Mengchu , Zhang Yanling , Liu Xianfei , Xie Dong , Zhang Qiongwei , Yang Huiling 
Published: August 2020

Abstract
A roof-mounted radiant cooling system incorporating a bypass structure, intended for use on liquid natural gas (LNG)-fueled refrigerated vehicles and offering stable dynamic regulation was designed. A model was established using the TRNSYS software package to simulate the operation of this system, and the effects of various factors on the refrigeration performance were analyzed. The quantitative relationship between the LNG flow rate and the ambient temperature was determined and a dynamic regulation strategy proposed. The results of this work show that, when the vehicle is operated at an economical speed, the cooling capacity provided by the system is greater than 1.2 kW, which meets the requirements for a refrigerated vehicle. The dynamic regulation approach developed in this study was found to allow use of the refrigerated vehicle under different climactic conditions and to improve the stability of the cooling system.
Fefferman–Stein Inequalities for the Hardy–Littlewood Maximal Function on the Infinite Rooted k-ary Tree
Authors: Ombrosi Sheldy , Rivera-Ríos Israel P , Safe Martín D 
Published: August 2020

Abstract
In this paper, weighted endpoint estimates for the Hardy–Littlewood maximal function on the infinite rooted $k$-ary tree are provided. Motivated by Naor and Tao [ 23], the following Fefferman–Stein estimate $$\begin{align*}& w\left(\left\{ x\in T\,:\,Mf(x)&gt;\lambda\right\} \right)\leq c_{s}\frac{1}{\lambda}\int_{T}|f(x)|M(w^{s})(x)^{\frac{1}{s}}\: \text{d}x\qquad s&gt;1\end{align*}$$is settled, and moreover, it is shown that it is sharp, in the sense that it does not hold in general if $s=1$. Some examples of nontrivial weights such that the weighted weak type $(1,1)$ estimate holds are provided. A strong Fefferman–Stein-type estimate and as a consequence some vector-valued extensions are obtained. In the appendix, a weighted counterpart of the abstract theorem of Soria and Tradacete [ 38] on infinite trees is established.
Bounding Tangencies of Sections on Elliptic Surfaces
Authors: Ulmer Douglas , Urzúa Giancarlo 
Published: August 2020

Abstract
Given an elliptic surface $\mathcal{E}\to \mathcal{C}$ over a field $k$ of characteristic zero equipped with zero section $O$ and another section $P$ of infinite order, we give a simple and explicit upper bound on the number of points where $O$ is tangent to a multiple of $P$.
Safe use of the EHR by medical scribes: a qualitative study
Authors: Ash Joan S , Corby Sky , Mohan Vishnu , Solberg Nicholas , Becton James , Bergstrom Robby , Orwoll Benjamin , Hoekstra Christopher , Gold Jeffrey A 
Published: August 2020

AbstractObjectiveHiring medical scribes to document in the electronic health record (EHR) on behalf of providers could pose patient safety risks because scribes often have no clinical training. The aim of this study was to investigate the effect of scribes on patient safety. This included identification of best practices to assure that scribe use of the EHR is not a patient safety risk.Materials and MethodsUsing a sociotechnical framework and the Rapid Assessment Process, we conducted ethnographic data gathering at 5 purposively selected sites. Data were analyzed using a grounded inductive/hermeneutic approach.ResultsWe conducted site visits at 12 clinics and emergency departments within 5 organizations in the US between 2017 and 2019. We did 76 interviews with 81 people and spent 80 person-hours observing scribes working with providers. Interviewees believe and observations indicate that scribes decrease patient safety risks. Analysis of the data yielded 12 themes within a 4-dimension sociotechnical framework. Results about the “technical” dimension indicated that the EHR is not considered overly problematic by either scribes or providers. The “environmental” dimension included the changing scribe industry and need for standards. Within the “personal” dimension, themes included the need for provider diligence and training when using scribes. Finally, the “organizational” dimension highlighted the positive effect scribes have on documentation efficiency, quality, and safety.ConclusionParticipants perceived risks related to the EHR can be less with scribes. If healthcare organizations and scribe companies follow best practices and if providers as well as scribes receive training, safety can actually improve.
A citizen science initiative for open data and visualization of COVID-19 outbreak in Kerala, India
Authors: Ulahannan Jijo Pulickiyil , Narayanan Nikhil , Thalhath Nishad , Prabhakaran Prem , Chaliyeduth Sreekanth , Suresh Sooraj P , Mohammed Musfir , Rajeevan E , Joseph Sindhu , Balakrishnan Akhil , Uthaman Jeevan , Karingamadathil Manoj , Thomas Sunil Thonikkuzhiyil , Sureshkumar Unnikrishnan , Balan Shabeesh , Vellichirammal Neetha Nanoth ,   the Collective for Open Data Distribution-Keralam (CODD-K) consortium
Published: August 2020

Abstract

Objective
India reported its first coronavirus disease 2019 (COVID-19) case in the state of Kerala and an outbreak initiated subsequently. The Department of Health Services, Government of Kerala, initially released daily updates through daily textual bulletins for public awareness to control the spread of the disease. However, these unstructured data limit upstream applications, such as visualization, and analysis, thus demanding refinement to generate open and reusable datasets.

Materials and Methods
Through a citizen science initiative, we leveraged publicly available and crowd-verified data on COVID-19 outbreak in Kerala from the government bulletins and media outlets to generate reusable datasets. This was further visualized as a dashboard through a front-end Web application and a JSON (JavaScript Object Notation) repository, which serves as an application programming interface for the front end.

Results
From the sourced data, we provided real-time analysis, and daily updates of COVID-19 cases in Kerala, through a user-friendly bilingual dashboard (https://covid19kerala.info/) for nonspecialists. To ensure longevity and reusability, the dataset was deposited in an open-access public repository for future analysis. Finally, we provide outbreak trends and demographic characteristics of the individuals affected with COVID-19 in Kerala during the first 138 days of the outbreak.

Discussion
We anticipate that our dataset can form the basis for future studies, supplemented with clinical and epidemiological data from the individuals affected with COVID-19 in Kerala.

Conclusions
We reported a citizen science initiative on the COVID-19 outbreak in Kerala to collect and deposit data in a structured format, which was utilized for visualizing the outbreak trend and describing demographic characteristics of affected individuals.
AMPK differentially alters sulphated glycosaminoglycans under normal and high glucose milieu in proximal tubular cells
Authors: Shrikanth C B , Jagannath Sanjana , Chilkunda Nandini D 
Published: August 2020

AbstractGlycosaminoglycans (GAGs) and AMP-activated protein kinase (AMPK) are two critical molecular players involved in cellular homeostasis. Both of them are altered due to hyperglycaemia in the kidney, leading to the pathogenesis of diabetic nephropathy. Here, we have looked into the effect of AMPK modulation on sulphated GAG (sGAG) levels of tubular cells of proximal and distal origin to understand the mechanism of hyperglycaemia-mediated pathogenesis of the diabetic nephropathy. In MDCK cells (distal tubular cell) and NRK-52E (proximal tubular cell), AMPK inhibition resulted in increased sGAG levels under normal glucose conditions characteristically of heparan sulphate class, whereas AMPK activation did not have any effect. High glucose (HG) condition did not alter sGAG levels in MDCK cell despite a decrease in AMPK phosphorylation. Subjecting NRK-52E cells to HG milieu significantly decreased sGAG levels more so of chondroitin/dermatan sulphate, which is significantly prevented when HG is co-treated with AMPK activator. Interestingly, knockdown of AMPK by AMPKα1/α2 siRNA showed increased sGAG levels in NRK-52E. Our results suggest that changes in sGAG level, in particular, as a result of AMPK modulation is differentially regulated and is dependent on cell type as well as its physiological status. Furthermore, activation of AMPK is beneficial in preventing the HG-mediated decrease in sGAGs in proximal tubular cells.