bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity assessment of self-reported medication use for hypertension, diabetes and dyslipidemia in a pharmacoepidemiologic study by comparison with health insurance claims
Authors: Matsumoto Minako , Harada Sei , Iida Miho , Kato Suzuka , Sata Mizuki , Hirata Aya , Kuwabara Kazuyo , Takeuchi Ayano , Sugiyama Daisuke , Okamura Tomonori , Takebayashi Toru 
Published: January 2020

Abstract
Background Although self-reported questionnaires are widely employed in epidemiologic studies, their validity has not been sufficiently assessed. The aim of this study was to evaluate the validity of a self-reported questionnaire on medication use by comparison with health insurance claims and to identify individual determinants of discordance.Methods Participants were 2,720 community-dwellers aged 37 to 78 years from the Tsuruoka Metabolomics Cohort Study. Information on lifestyle and medications was collected through a questionnaire. Sensitivity and specificity were determined using health insurance claims from November 2014 to March 2016, which were used as a standard. Potential determinants of discordance were assessed by multivariable logistic regression.Results The self-reported questionnaire on medication use showed high validity. Sensitivity and specificity were 0.95 (95% CI:0.93-0.96) and 0.94 (0.93-0.95) for antihypertensives, 0.94 (0.91-0.97) and 0.98 (0.98-0.99) for diabetes medications, 0.84 (0.82-0.87) and 0.96 (0.95-0.97) for dyslipidemia medications, respectively. Males without high education were found to be associated with discordant reporting, especially those with medication use for dyslipidemia.Conclusions In this population-based study, we found that the self-reported questionnaire on medication use was a valid measure of true medication use. Sensitivity for dyslipidemia medications was lower than those for the other medications. Type of medication, gender and education influenced discordance in self-reporting.
RNA-seq analysis of galaninergic neurons from ventrolateral preoptic nucleus identifies expression changes between sleep and wake
Authors: Guo Xiaofeng , Gao Xiaoling , Keenan Brendan T. , Zhu Jingxu , Sarantopoulou Dimitra , Lian Jie , Galante Raymond J. , Grant Gregory R. , Pack Allan I. 
Published: January 2020

Abstract
Background : Previous studies show that galanin neurons in ventrolateral preoptic nucleus (VLPO-Gal) are essential for sleep regulation. Here, we explored the function of the VLPO-Gal neurons in sleep by comparing their transcriptional responses between sleeping mice and those kept awake, sacrificed at the same diurnal time. Results : RNA-sequencing (RNA-seq) analysis was performed on eGFP(+) galanin neurons isolated using laser captured microdissection (LCM) from VLPO. Expression of Gal was assessed in our LCM eGFP(+) neurons via real time qPCR and showed marked enrichment when compared to LCM eGFP(-) neurons and to bulk VLPO samples. Gene set analysis utilizing data from a recent single-cell RNA-seq study of the preoptic area demonstrated that our VLPO-Gal samples were highly enriched with galanin-expressing inhibitory neurons, but not galanin-expressing excitatory neurons. A total of 263 genes were differentially expressed between sleep and wake in VLPO-Gal neurons. When comparing differentially expressed genes in VLPO-Gal neurons to differentially expressed genes in a wake-active neuronal region (the medial prefrontal cortex), evidence indicates that both systemic and cell-specific mechanisms contribute to the transcriptional regulation in VLPO-Gal neurons. In both wake-active and sleep-active neurons, ER stress pathways are activated by wake and cold-inducible RNA-binding proteins are activated by sleep. In contrast, expression of DNA repair genes is increased in VLPO-Gal during wakefulness, but increased in wake-active cells during sleep. Conclusion : Our study identified transcriptomic responses of the galanin neurons in the ventrolateral preoptic nucleus (VLPO) during sleep and sleep deprivation. Data indicate that VLPO contains mainly sleep-active inhibitory galaninergic neurons. The VLPO galanin neurons show responses to sleep and wake similar to wake-active regions, indicating these responses, such as ER stress and cold-inducible RNA-binding proteins, are systemic affecting all neuronal populations. Region-specific differences in sleep/wake responses were also identified, in particular DNA repair, suggesting these could be driven by neuronal activity. Our study expands knowledge about the transcriptional response of a distinct group of neurons essential for sleep.
“Everything is provided free, but they are still hesitant to access healthcare services”: Why does the Indigenous community in Attapadi, Kerala continue to experience poor access to healthcare?
Authors: George Mathew Sunil , Davey Rachel , Mohanty Itismita , Upton Penney 
Published: January 2020

Abstract
Background Inequity in access to healthcare services is a constant concern. While advances in healthcare have progressed in the last several decades, thereby significantly improving the prevention and treatment of disease, these benefits have not been shared equally. Excluded communities such as Indigenous communities typically face a lack of access to healthcare services that others do not. This study seeks to understand why the indigenous community in Attapadi continues to experience poor access to healthcare in spite of both financial protection and adequate coverage of health services Methods Ethnographic fieldwork was carried out among the various stakeholders living in Attapadi . A total of 52 in-depth interviews and 5 focus group discussions were conducted amongst the indigenous community, the healthcare providers and key informants. The data was coded utilising a reflexive and inductive approach leading to the development of the key categories and themes Results The health system provided a comprehensive financial protection package in addition to a host of healthcare facilities for the indigenous community to avail services. In spite of this, the community resisted the attempts of the health system to improve their access. The failure to provide culturally respectful care, the discrimination of the community at healthcare facilities, the centralisation of the delivery of services as well as the lack of power among the indigenous community to negotiate with the health system for services that were less disruptive to their lives were barriers to improving healthcare access. Power differentials between the community and the health system stakeholders also ensured that meaningful involvement of the community in the local health system did not occur. Conclusion Improving access to health care for indigenous communities would require UHC interventions to be culturally safe, locally relevant and promote active involvement of the community at all stages of the intervention. Structural power imbalances that affect access to resources and prevent meaningful involvement of indigenous communities also need to be addressed.
The relational development of infants with CLP: impact on parents and on the parent-infant relationship. Results from the first French prospective multicenter CLP study.
Authors: GROLLEMUND BRUNO , Dissaux Caroline , Gavelle Pascale , Martinez Carla Perez , Mullaert Jimmy , Alfaiate Toni , Guedeney Antoine 
Published: January 2020

Abstract
Background : The objective of this prospective, multidisciplinary and multicenter study was to explore the impact of a cleft lip, whether or not in association with a cleft palate (CLP) on the parents, on the parent-infant relationship, and on the infant’s relational development, depending on the type of malformation and the timing of the repair surgery, at 4 and 12 months postpartum. Method : 158 infants with CLP and their parents participated in this multicenter prospective cohort. Clinical evaluations were performed at 4 and 12 months postpartum. The impact on the parents and on the parent-infant relationship was evaluated by the Parenting Stress Index (PSI), the Edinburgh Post-partum Depression Scale (EPDS) and the Impact-on-Family Scale (IOFS). The relational development of the infant was assessed using the Alarm Distress Baby Scale (ADBB). The main criteria used to compare the infants were the severity of CLP and the time of surgery. Results 1) No effect was found in this sample of the timing of surgery, the type of malformation or the care structure on social withdrawal behaviors of the child at 4 and 12 months postpartum (ADBB). Furthermore, early intervention significantly decreased maternal stress assessed with the PSI at 4 months. 2) Parents for whom it had been possible to give a prenatal diagnosis were much better prepared to accept the waiting time between birth and the first surgical intervention (PSI, EPDS, IOFS). 3) Higher postpartum depression scores (EPDS) were found for both parents compared to the general population. Conclusion : A joint assessment of the mental health of both infants and parents is required in the follow-up of cleft lip and palate. Even if most families are remarkably resilient when faced with this major cause of stress, a significant proportion of them could require help to deal with the situation, especially during this first year of follow-up. An assessment of social withdrawal behaviours in the child and of the level of parental stress and depression appears useful, in order to adapt care to infant and parents alike. Trial Registration: ClinicalTrials.gov Identifier: NCT00993993. Registered 10/14/2009, https://clinicaltrials.gov/ct2/show/NCT00993993?term=grollemund&draw=2&rank=1.
Better efficacy in differentiating WHO grade II from III oligodendrogliomas with machine-learning than radiologist’s reading from conventional T1 contrast-enhanced and fluid attenuated inversion recovery images
Authors: Zhao Sha-Sha , Feng Xiu-Long , Hu Yu-Chuan , Han Yu , Tian Qiang , Sun Ying-Zhi , Zhang Jie , Ge Xiang-Wei , Cheng Si-Chao , Li Xiu-Li , Mao Li , Shen Shu-Ning , Yan Lin-Feng , Cui Guang-Bin , Wang Wen 
Published: January 2020

Abstract
Background: The medical imaging to differentiate World Health Organization (WHO) grade II (ODG2) from III (ODG3) oligodendrogliomas still remains a challenge. We investigated whether combination of machine leaning with radiomics from conventional T1 contrast-enhanced (T1CE) and fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) offered superior efficacy. Methods: Thirty-six patients with histologically confirmed ODGs underwent T1CE and 33 of them underwent FLAIR MR examination before any intervention from January 2015 to July 2017 were retrospectively recruited in the current study. The volume of interest (VOI) covering the whole tumor enhancement were manually drawn on the T1CE and FLAIR slice by slice using ITK-SNAP and a total of 1072 features were extracted from the VOI using 3-D slicer software. Random forest (RF) algorithm was applied to differentiate ODG2 from ODG3 and the efficacy was tested with 5-fold cross validation. The diagnostic efficacy of radiomics-based machine learning and radiologist’s assessment were also compared. Results: Nineteen ODG2 and 17 ODG3 were included in this study and ODG3 tended to present with prominent necrosis and nodular/ring-like enhancement (P < 0.05). The AUC, ACC, sensitivity, and specificity of radiomics were 0.798, 0.735, 0.672, 0.789 for T1CE, 0.774, 0.689, 0.700, 0.683 for FLAIR, as well as 0.861, 0.781, 0.778, 0.783 for the combination, respectively. The AUCs of radiologists 1, 2 and 3 were 0.700, 0.687, and 0.714, respectively. The efficacy of machine learning based on radiomics was superior to the radiologists' assessment. Conclusions: Machine-learning based on radiomics of T1CE and FLAIR offered superior efficacy to that of radiologists in differentiating ODG2 from ODG3.
Leak Detection
Authors: Hamilton Stuart , Charalambous Bambos 
Published: January 2020

Ageing infrastructure and declining water resources are major concerns with a growing global population. Controlling water loss has therefore become a priority for water utilities around the world. In order to improve their efficiencies, water utilities need to apply good practice in leak detection.
To deal with losses in an effective manner, particularly from networks in water-scarce areas, water utility managers are increasingly turning to technology to reduce costs, increase efficiency and improve reliability. Companies that continuously invest in technology and innovation should see a positive return on investment in terms of improving daily operations and collection and analysis of network data for decisionmaking and forward planning.
Methodologies for achieving the best results to reduce water losses are continuously evolving. Water utilities and equipment manufacturers are increasingly working together to stretch the boundaries of current knowledge. This is leading to some innovative technologies and new product development to complement current methodologies. This book reflects the situation at the time of publication.
This second edition of the book updates practices and technologies that have been introduced or further developed in recent years in leakage detection. It outlines recent advancements in technology used, such as satellite aided methods in leak location, pipeline inspection with thermal diagnostics, inspection of pipelines by air using infrared or thermal imaging cameras, drones for leak detection activities and even sniffer dogs. In addition, it is enriched with new case studies that provide useful examples of practical applications of several leak detection practices and technologies.
ISBN: 9781789060843 (paperback)
ISBN: 9781789060850 (eBook)
ISBN: 9781789060867 (ePub)
Water in military stabilisation operations: comprehensive water intervention framework for conflict management and peacekeeping
Authors: Huizinga R. P. , Enserink B. 
Published: January 2020

Abstract
Water issues can be a root cause of political instability, but even in times of crisis, and especially in the aftermath of war, water management also requires and contributes towards co-operation. Within the complexity of military stabilisation operations, water management has been identified as a potentially suitable crisis and conflict management tool. Therefore, a comprehensive and appropriate approach to apply water throughout the entire process of transition from a conflict, post-conflict or unstable region towards stability, peace and prosperity is desirable. During the Dutch military stabilisation mission in the Afghan province of Uruzgan, water management was applied effectively by the Netherlands Army as an instrument to create stability and co-operation in the conflict and post-conflict period. Based on this experience, a Comprehensive Water Intervention Framework is presented in this paper. By integrating water management, military, development, diplomacy and co-operation approaches, this framework provides practical guidance for policymakers, mission planners and field officers. Its implementation follows after the initial military intervention and within the stabilisation operation, as a mechanism contributing to peacekeeping and development efforts. The framework can also be further improved, most notably by integrating land management and experiences gained from its implementation in civil–military exercises and from its actual application in stabilisation operations.
The bottlenecks and causes, and potential solutions for municipal sewage treatment in China
Authors: Cao Yeshi , Van Loosdrecht M. C. M. , Daigger Glen. T. 
Published: January 2020

AbstractSince about the 1990s China has achieved remarkable progress in urban sanitation. The country has built very extensive infrastructure for wastewater treatment, with 94.5% treatment coverage in urban areas and legally mandated nation-wide full nutrient removal implemented. However, municipal wastewater treatment plants (WWTPs) in China are still confronted with issues rooted in the unique sewage characteristics. This study compares energy recovery, cost of nutrient removal and sludge production between Chinese municipal WWTPs and those in countries with longer wastewater treatment traditions, and highlights the cause-effect relationships between Chinese sewage characteristics – high inorganic suspended solids (ISS) loads, and low COD and C/N ratio, and municipal WWTP process performance in China. Integrated design and operation guidelines for municipal WWTPs are imperative in relation to the unique sewage characteristics in China. Cost-effective measures and solutions are proposed in the paper, and the potential benefits of improving the sustainability of municipal WWTPs in China are estimated.
Treatment of sidestream dewatering liquors from thermally hydrolised and anaerobically digested biosolids
Authors: Driessen W. , Van Veldhoven J. T. A. , Janssen M. P. M. , Van Loosdrecht M. C. M. 
Published: January 2020

Abstract
A long term operation (22 months) of the sidestream treatment plant at the water and resource recovery facility at the Tilburg sewage works in The Netherlands is presented. This plant treats dewatering reject liquor from thermally hydrolysed (THP) and mesophillic anaerobically digested (MAD) biosolids. The sidestream plant is comprised of a Phospaq struvite reactor for removal and recovery of phosphate and an Anammox reactor for removal of ammoniacal nitrogen. Potential inhibiting characteristics of THP-MAD reject liquor were successfully mitigated by various measures like pre-aeration and addition of dilution water. The sidestream plant demonstrated excellent performance in handling large fluctuations in load and composition, producing effluent with stable low NH4 and BOD concentrations achieving removal efficiencies up to 90% on both NH4 and BOD.
Current Nanoparticle Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review
Authors: Ansari Mohammad A. , Chung Ill-Min , Rajakumar Govindasamy , Alzohairy Mohammad A. , Alomary Mohammad N. , Thiruvengadam Muthu , Pottoo Faheem H. , Ahmad Niyaz 
Published: January 2020

:
Nanoparticles (NPs) are unique may be organic or inorganic, play a vital role in the development of
drug delivery targeting the central nervous system (CNS). Intranasal drug delivery has shown to be an efficient
strategy with attractive application for drug delivery to the CNS related diseases, such as Parkinson's disease,
Alzheimer 's disease and brain solid tumors. Blood brain barrier (BBB) and blood-cerebrospinal fluid barriers are
natural protective hindrances for entry of drug molecules into the CNS. Nanoparticles exhibit excellent intruding
capacity for therapeutic agents and overcome protective barriers. By using nanotechnology based NPs targeted,
drug delivery can be improved across BBB with discharge drugs in a controlled manner. NPs confer safe from
degradation phenomenon. Several kinds of NPs are used for nose to the brain (N2B) enroute, such as lipidemic
nanoparticles, polymeric nanoparticles, inorganic NPs, solid lipid NPs, dendrimers. Among them, popular lipidemic
and polymeric NPs are discussed, and their participation in anti-cancer activity has also been highlighted in
this review.
SO3H-functionalized Zeolite-Y as an Efficient Nanocatalyst for the Synthesis of Nbenzimidazole- 2-aryl-4-thiazolidinones and tri-substituted Imidazoles
Authors: Kalhor Mehdi , Zarnegar Zohre , Seyedzade Zahra , Banibairami Soodabeh 
Published: January 2020

Background:
SO3H-functionalized zeolite-Y was prepared and used as a catalyst for the synthesis of
2-aryl-N-benzimidazole-4-thiazolidinones and tri-substituted imidazoles at ambient conditions.

Objective:
The goals of this catalytic method include excellent yields and high purity, inexpensive procedure
and ease of product isolation, the use of nontoxic and heterogeneous acid catalyst, shorter reaction times and
milder conditions.

Materials and Methods:
NMR spectra were recorded on Brucker spectrophotometer using Me4Si as internal
standard. Mass spectra were recorded on an Agilent Technology 5975C VL MSD with tripe-axis detector. FTIR
spectra were obtained with KBr disc on a galaxy series FT-IR 5000 spectrometer. The surface morphology
of nanostructures was analyzed by FE-SEM (EVO LS 10, Zeiss, Carl Zeiss, Germany). BET analysis were
measured at 196 °C by a Japan Belsorb II system after the samples were vacuum dried at 150°C overnight.

Results:
The NSZ was characterized by FT-IR, FESEM, EDX, XRF, and BET. The catalytic activity of NSZ
was investigated for synthesis of 1,3-tiazolidin-4-ones in H2O/Acetone at room temperature. Moreover, NSZ
was used for synthesis of tri-substituted imidazoles at 60 °C via solvent-free condensation. Different kinds of
aromatic aldehydes were converted to the corresponding of products with good to excellent yields.

Conclusion:
Sulfonated zeolite-Y was as an efficient catalyst for the preparation of N-benzimidazole-2-aryl-1,3-
thiazolidin-4-ones and 2,4,5-triaryl-1H-imidazoles. High reaction rates, elimination toxic solvent, simple experimental
procedure and reusability of the catalyst are the important features of this protocol.
New Spectrophotometric Method for the Assessment of Catalase Enzyme Activity in Biological Tissues
Authors: Hamza Thulfeqar A. , Hadwan Mahmoud H. 
Published: January 2020

Background:
Catalase is a vital antioxidant enzyme that dismutates H2O2 into water and
molecular oxygen. Many protocols have been developed to measure catalase enzyme activity. Spectrophotometric
methods are the most common assays that used to assess catalase enzyme activity.

Methods:
Because the rate-limiting step during catalase enzyme activity depends upon the dissociation
of hydrogen peroxide, the developed assay measures the reaction between a hydroquinone/
anilinium sulfate/ammonium molybdate reagent and Unreacted Hydrogen Peroxide, which results in
the production of a purple, disubstituted quinone compound with a maximum absorbance value at
550 nm.

Results:
To clarify the precision of the developed method, the coefficients of variation were determined
to be 2.6% and 4.7% within run measurements and between run measurements, respectively.
This method returned results that correlated well (r = 0.9982) with the results returned using the
peroxovanadate method to assess catalase enzyme activity. Additionally, we examined the use of the
newly developed hydroquinone assay to measure catalase enzyme activity in liver and bacterial homogenate
samples.

Conclusion:
These results demonstrated that this assay can be used for scientific research and routine
health applications because it is inexpensive, simple, accurate, and rapid. This method is suitable for
use in clinical pathology laboratories because it is simple and produces precise and reproducible results.