bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matrine involves in the progression of gastric cancer through inhibiting miR‐93‐5p and upregulating the expression of target gene AHNAK
Authors: Liu Zhi‐Min , Yang Xiao‐Li , Jiang Feng , Pan Yan‐Cheng , Zhang Li 
Published: November 2019

AbstractMatrine, also known as oxymatrine, is an important active ingredient of traditional Chinese herb Sophora flavescens. Recent studies have found that matrine may inhibit multiple tumors through inhibiting the tumor cell proliferation, inducing cell apoptosis, blocking cell cycle, suppressing cell invasion and migration and assisting in the synergy, and attenuation of radiotherapy and chemotherapy. This study mainly investigated the role of matrine in gastric cancer and its possible mechanism. The real‐time fluorescence quantitative polymerase chain reaction technique showed that matrine inhibited the proliferation and migration of gastric tumor cells and significantly suppressed the expression of miR‐93‐5p. The dual‐luciferase reporter gene assay indicated that AHNAK was a target gene of miR‐93‐5p and regulated by miR‐93‐5p and matrine. The torsion test demonstrated that matrine exerted its role via miR‐93‐5p while miR‐93‐5p played a role by targeting AHNAK. Thus, this study found that matrine affected the progression of gastric cancer by inhibiting the function of gastric cancer cells through the possible mechanism of inhibiting miR‐93‐5p expression to increase the expression level of the downstream target gene AHNAK.
Circular RNA hsa_circ_0030018 acts as a sponge of miR‐599 to aggravate esophageal carcinoma progression by regulating ENAH expression
Authors: Wang Chengxiang , Tang Derong , Wang Hongying , Hu Guodong , Hu Shuo , Li Lei , Min Bo , Wang Yaqin 
Published: November 2019

AbstractEsophageal carcinoma (EC) bears one of the most rapid‐growing incidences in cancers, which also has the highest mortality rate worldwide. Multiple studies have authenticated that circular RNAs (circRNAs) significantly work on the progression of cancers. circRNA hsa_circ_0030018 was also verified to exert functions on the development of glioma previously. Nevertheless, the biological function of hsa_circ_0030018 in EC has not been well elucidated yet. In the present study, the results displayed the expression of hsa_circ_0030018 was dramatically increased in EC cells. Inhibition of has_circ_0030018 suppressed cell proliferation, migration, and epithelial‐mesenchymal transition (EMT) process in EC. Based on molecular mechanism assays, has_circ_0030018 served as a sponge of miR‐599. Enabled homolog (ENAH), which exhibited high expression in EC cells, was confirmed to be a downstream target gene of miR‐599. Additionally, has_circ_0030018 positively regulated ENAH expression while miR‐599 negatively regulated ENAH expression. Finally, by employing rescue assays, ENAH deficiency partially counteracted the promoting function of miR‐599 silence on cell proliferation, migration, and EMT process in EC cotransfected with sh‐ has_circ_0030018#1 cells. In conclusion, hsa_circ_0030018 acted as a sponge of miR‐599 to aggravate EC progression by regulating ENAH expression. Therefore, hsa_circ_0030018 might serve as a promising biomarker and therapeutic target for EC.
Retracted: Crystal structure, molecular docking, and treatment activity on myocarditis of a co‐Schiff‐base coordination polymer
Authors: Bai Dong‐Song , Bai Li‐Ying , Zhao Ming , Zhang Qing‐Shan 
Published: November 2019

AbstractThis work presents the synthesis and characterization of a dicyanamide‐bridged coordination polymer {[Co2(L)2(dca)2](H2O)}n (named complex 1 hereafter) by using the N,O‐donor Schiff base ligand 2‐(((E)‐2‐(((E)‐2‐hydroxybenzylidene)amino)benzylidene)amino)phenol (H2L). Furthermore, the nanoparticles of complex 1 (denoted as nano 1 hereafter) were prepared using a green grinding approach, which has good water dispersibility. First, the coxsackievirus B3 (CVB3) infection mice model was constructed successfully, and then, the nano 1 was used for treatment. Reverse transcription‐polymerase chain reaction (RT‐PCR) was performed to detect the CVB3 virus loading after nano 1 treatment. Besides, the left ventricular fractional shortening and the left ventricular ejection fraction were measured to evaluate the protective effect of nano 1 on cardiac functions. The hypothesis originating from the experimental observations has been further confirmed by using a molecular docking simulation.
Synthesis of carboxy‐polyethylene glycol‐amine (CA (PEG)n) and [1‐14C]‐CA (PEG)n via oxa‐Michael addition of amino‐polyethylene glycols to propiolates vs to acrylates
Authors: Song Fengbin , Chen Lu , Lin Ronghui , Salter Rhys 
Published: November 2019

AbstractSynthesis of carboxy‐polyethylene glycol‐amine (CA (PEG)n) via oxa‐Michael addition of amino‐polyethylene glycols to either acrylates or propiolates was investigated. Compared with the oxa‐Michael addition to acrylates, the corresponding addition to propiolates was found to proceed under mild reaction conditions and afford the adducts in high yields from a broad scope of substrates. A two‐step efficient and convenient synthesis of benzyl [1‐14C]‐propiolate from 14CO2 was therefore developed and utilized as a common synthon to afford practical and high yielding access to [1‐14C]‐CA (PEG)n.
Scan–Rescan Repeatability and Impact of B0 and B1 Field Nonuniformity Corrections in Single‐Point Whole‐Brain Macromolecular Proton Fraction Mapping
Authors: Yarnykh Vasily L. , Kisel Alena A. , Khodanovich Marina Y. 
Published: November 2019

BackgroundSingle‐point macromolecular proton fraction (MPF) mapping is a recent quantitative MRI method for fast assessment of brain myelination. Information about reproducibility and sensitivity of MPF mapping to magnetic field nonuniformity is important for clinical applications.PurposeTo assess scan–rescan repeatability and a value of B0 and B1 field inhomogeneity corrections in single‐point synthetic‐reference MPF mapping.Study TypeProspective.PopulationEight healthy adult volunteers underwent two scans with 11.5 ± 2.3 months interval.Field Strength/Sequence3T; whole‐brain 3D MPF mapping protocol included three spoiled gradient‐echo sequences providing T1, proton density, and magnetization transfer contrasts with 1.25 × 1.25 × 1.25 mm3 resolution and B0 and B1 mapping sequences.AssessmentMPF maps were reconstructed with B0 and B1 field nonuniformity correction, B0‐ and B1‐only corrections, and without corrections. Mean MPF values were measured in automatically segmented white matter (WM) and gray matter (GM).Statistical TestsWithin‐subject coefficient of variation (CV), intraclass correlation coefficient (ICC), Bland–Altman plots, and paired t‐tests to assess scan–rescan repeatability. Repeated‐measures analysis of variance (ANOVA) to compare field corrections.ResultsMaximal relative local MPF errors without correction in the areas of largest field nonuniformities were about 5% and 27% for B0 and B1, respectively. The effect of B0 correction was insignificant for whole‐brain WM (P > 0.25) and GM (P > 0.98) MPF. The absence of B1 correction caused a positive relative bias of 4–5% (P < 0.001) in both tissues. Scan–rescan agreement was similar for all field correction options with ICCs 0.80–0.81 for WM and 0.89–0.92 for GM. CVs were 1.6–1.7% for WM and 0.7–1.0% for GM.Data ConclusionThe single‐point method enables high repeatability of MPF maps obtained with the same equipment. Correction of B0 inhomogeneity may be disregarded to shorten the examination time. B1 nonuniformity correction improves accuracy of MPF measurements at 3T. Reliability of whole‐brain MPF measurements in WM and GM is not affected by B0 and B1 field corrections.Level of Evidence: 2Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2020;51:1789–1798.
Role of antibiotic envelopes in preventing cardiac implantable electronic device infection: A meta‐analysis of 14 859 procedures
Authors: Kumar Ashish , Doshi Rajkumar , Shariff Mariam 
Published: November 2019

AbstractIntroductionWe conducted an updated meta‐analysis assessing the role of antibiotic envelopes in preventing Cardiac implantable electronic devices (CIED)‐related infections as compared to standard infection prevention strategies.MethodsA systematic search was conducted on Medline/PubMed and EMBASE/Ovid database. We used Mantel‐Haenszel method with fixed‐effect model to compute risk ratio (RR) with 95% confidence interval (CI). We also performed subgroup and trial sequential analysis on the data.ResultsAntibiotic envelope reduced the risk of both all infections [RR: 0.41, CI: 0.31‐0.54, P < .05, I2 = 75%, χ2 P < .05] and major infections [RR: 0.48, CI: 0.32‐0.70, P < .05, I2 = 60%, χ2 P = .04].ConclusionProphylactic use of antibiotic envelopes as an adjuvant therapy to standard infection prevention strategies, helps in reducing the risk of CIED infections.
Contribution of the colicin receptor CirA to biofilm formation, antibotic resistance, and pathogenicity of Salmonella Enteritidis
Authors: Zhang Zhiqiang , Du Wannian , Wang Miao , Li Yonghui , Su Shuoqing , Wu Tonglei , Kang Yuanhuan , Shan Xiaofeng , Shi Qiumei , Zhu Guoqiang 
Published: November 2019

AbstractSalmonella Enteritidis is an important foodborne pathogen that can infect a wide range of animal species including human beings, resulting in great losses to commercial husbandry and human health. CirA is an outer membrane receptor involved in iron uptake and colicin1A/B‐mediated competitive killing. Although iron uptake is crucial to bacterial virulence, limited literature is available about the role of CirA in infection. In the present work, we aimed to evaluate the role of CirA during S. Enteritidis infection. For this purpose, we generated a CirA‐deficient mutant of the S. Enteritidis strain C50336 and examined its biological characteristics. The results showed that cirA gene inactivation caused sharply decreased biofilm formation and apparently impaired antibiotic resistance. Furthermore, the cirA gene deletion mutant showed markedly reduced adhesion and invasion to human epithelial cell line Caco‐2 cells and decreased proliferation in mouse macrophage cell line RAW264.7 cells. Moreover, attenuated virulence was determined by a mouse model, with an LD50 increase of approximately 1,000‐fold. These data indicated that CirA plays critical roles in the S. Enteritidis infection process.
Survival Analysis of Enterally Fed Patients: Prognosis and Mortality Risk According to Baseline Characteristics
Authors: Iturbide‐Casas María Aurora , Cámara‐Martos Fernando , Molina‐Luque Rafael , Molina‐Recio Guillermo 
Published: November 2019

AbstractBackground: Enteral nutrition is widely used. However, its benefits remain unclear in specific conditions like dementia. This study assesses the survival of enterally fed patients and the baseline characteristics associated with higher mortality. Methods: A retrospective analysis of biochemical and clinical data from 377 patients (age 77.5 ± 13.8) who received enteral tube feeding (ETF) at a tertiary hospital in Spain was performed. Kaplan‐Meier and Cox regressions were used to analyze survival expectancy and mortality risk (MR). Risk was evaluated for 30/180 days and up to 5 years. Results: The most common individual diagnoses leading to ETF prescription were dementia (37.9%) and head/neck/upper–gastrointestinal‐tract cancer (17.5%). Comorbidities (high blood pressure [HBP] and/or diabetes) were present in 72.4% of patients. The first 30 days after tube placement showed the highest mortality rate, corresponding to 85.4% of patients that did not continue being tube‐fed. Multivariate Cox analysis (P < .05, 95% CI) showed HBP and glycemia to be predictive of overall (hazard ratio [HR] = 1.600; HR = 1.756) and long‐term (HR = 3.092; HR = 4.539) death. In the short‐term, only glycemia showed an increased MR (HR = 1.572). Conclusion: This enterally fed population showed a noticeably high initial mortality rate. Despite official recommendations against it, ETF is very common in advanced dementia. Baseline characteristics are useful for identifying patients that would be less benefited by the intervention. Accordingly, families should be informed about realistic outcomes and risks derived from this procedure.
Discovery of cryptotephra at Middle–Upper Paleolithic sites Arma Veirana and Riparo Bombrini, Italy: a new link for broader geographic correlations
Authors: Hirniak Jayde N. , Smith Eugene I. , Johnsen Racheal , Ren Minghua , Hodgkins Jamie , Orr Caley , Negrino Fabio , Riel‐Salvatore Julien , Fitch Shelby , Miller Christopher E. , Zerboni Andrea , Mariani Guido S. , Harris Jacob A. , Gravel‐Miguel Claudine , Strait David , Peresani Marco , Benazzi Stefano , Marean Curtis W. 
Published: November 2019

ABSTRACTChemical characterization of cryptotephra is critical for temporally linking archaeological sites. Here, we describe cryptotephra investigations of two Middle–Upper Paleolithic sites from north‐west Italy, Arma Veirana and Riparo Bombrini. Cryptotephra are present as small (<100 µm) rhyolitic glass shards at both sites, with geochemical signatures rare for volcanoes in the Mediterranean region. Two chemically distinct shard populations are present at Arma Veirana (P1 and P2). P1 is a high silica rhyolite (>75 wt.%) with low FeO (<1 wt.%) and a K2O/Na2O > 1 and P2 is also a high silica rhyolite (>75 wt.%) but with higher FeO (2.33–2.65 wt.%). Shards at Riparo Bombrini (P3) are of the same composition as P1 shards at Arma Veirana, providing a distinct link between deposits at both sites. Geochemical characteristics suggest three possible sources for P1 and P3: eruptions from Lipari Island (56–37.7 ka) in Italy, the Acigöl volcanic field (200–20 ka) in Turkey and the Miocene Kirka‐Phrigian caldera (18 Ma) in Turkey. Eruptions from Lipari Island are the most likely source for P1,3 cryptotephra. This study highlights how cryptotephra can benefit archaeology, by providing a direct link between Arma Veirana and Riparo Bombrini as well as other deposits throughout the Mediterranean.
Analytical Method for Diacylglycerol Kinase ζ Activity in Cells Using Protein Myristoylation and Liquid Chromatography–Tandem Mass Spectrometry
Authors: Honda Shotaro , Murakami Chiaki , Yamada Haruka , Murakami Yuki , Ishizaki Ayuka , Sakane Fumio 
Published: November 2019

AbstractSpecific inhibitors of diacylglycerol kinase (DGK) ζ can be promising anticancer medications via the activation of cancer immunity. Although the detection of cellular activities of target enzymes is essential for drug screening in addition to in vitro assays, it is difficult to detect the activity of DGKζ in cells. In the present study, we generated AcGFP‐DGKζ cDNA with a consensus N‐myristoylation sequence at the 5′ end (Myr‐AcGFP‐DGKζ) to target DGKζ to membranes. Using liquid chromatography (LC)‐tandem mass spectrometry (MS/MS) (LC–MS/MS), we showed that Myr‐AcGFP‐DGKζ, but not AcGFP‐DGKζ without the myristoylation sequence, substantially augmented the levels of several phosphatidic acid (PtdOH) species. In contrast to Myr‐AcGFP‐DGKζ, its inactive mutant did not exhibit an increase in PtdOH production, indicating that the increase in PtdOH production was DGK activity‐dependent. This method will be useful in chemical compound selection for the development of drugs targeting DGKζ and can be applicable to various soluble (nonmembrane bound) lipid‐metabolizing enzymes, including other DGK isozymes.
Hot Polarons with Trapped Excitons and Octahedra‐Twist Phonons in CH3NH3PbBr3 Hybrid Perovskite Nanowires
Authors: Song Feilong , Qian Chenjiang , Wang Yunuan , Zhang Feng , Peng Kai , Wu Shiyao , Xie Xin , Yang Jingnan , Sun Sibai , Yu Yang , Dang Jianchen , Xiao Shan , Yang Longlong , Jin Kuijuan , Zhong Haizheng , Xu Xiulai 
Published: November 2019

AbstractHybrid Perovskites have shown a great potential for applications in photovoltaics and light‐emitting devices with high efficiency. Interaction between defect‐induced trapped excitons and phonons plays an important role in understanding the emerging phenomena for such an excellent figure‐of‐merit. Here hot polarons with narrow linewidth in CH3NH3PbBr3 nanowires, which originate from the interaction between trapped excitons and octahedra‐twist phonons, are demonstrated. The observation of hot polarons in photoluminescence without gain methods indicates the large interaction strength between excitons and phonons. The multiple hot polarons are further confirmed by magneto‐optical spectra with a Zeeman splitting of the trapped excitons and a phonon energy increase with diamagnetic effect. Furthermore, the phonons participating in the interaction are demonstrated to be the octahedra‐twist vibrations which are transverse optical phonons, while the interaction between trapped excitons and longitudinal optical phonons is weak. The work demonstrates that trapped excitons in perovskites prefer to interact with transverse rather than longitudinal optical phonons. Since bulk materials usually interact with longitudinal optical phonons, this result provides a physical explanation of the high tolerance of defects in perovskites.
Insight into selective oxidation of dual‐phase steel after annealing in pure H2 atmosphere at different heating rates and temperatures
Authors: Wu Guangxin , Zhang Jieyu 
Published: November 2019

AbstractIn this paper, the oxidation behaviors of DP980 advanced high strength steel (AHSS) are studied during annealing in a hydrogen atmosphere with different temperatures and heating rates. It is revealed that with the increase in holding time, the different heating rates affecting the surface oxide precipitation on the strip surface will be weakened. Mass transfer of Mn in heating, soaking, and cooling stages has been considered to illustrate the effect of heating rate on the oxide morphology of steel. And then, the Wagner model and aluminothermic reaction kinetics were performed to discuss the transition from external to internal and maximum reduction diameter of MnO oxidation.
Role of polyacrylamide concentration on corrosion behavior of N80 steel in the HPAM/H2S/CO2 environment
Authors: Dong Baojun , Zeng Dezhi , Yu Zhiming , Zhang Haixin , Yu Huiyong , Tian Gang , Yi Yonggang 
Published: November 2019

AbstractThe effect of polyacrylamide on corrosion behavior of N80 steel in the HPAM/H2S/CO2 environment was studied by using weight‐loss and electrochemical tests to simulate the environment of production wells in polymer flooding. The morphology and composition of corrosion scales were studied by scanning electron microscopy, energy dispersive X‐ray spectrometer, and X‐ray photoelectron spectroscopy. The results show that as the polyacrylamide concentration increases, the uniform corrosion rate of N80 steel decreases gradually. The safe service life of N80 steel grows along with the increase of the concentration of polyacrylamide. The corrosion scales of N80 steel in the HPAM/H2S/CO2 environment is split into two layers, an inner layer of O‐rich composed of FeCO3 and an outer layer of S‐rich consisting of FeS. Polyacrylamide adsorbs on the surface of N80 steel to form a protective network, which blocks contact between the metal and the solution and then inhibits the anodic dissolution of the metal. Moreover, the growth of polyacrylamide concentration increases the pH value of the solution and promotes the ionization of H2S, HS−, and H2CO3 in the solution.
Metal‐Free Ring‐Opening Alternating Copolymerization of Epoxides and Cyclic Anhydrides Mediated by a Ternary Phosphazene Base and Carboxylic Acids
Authors: Kou Xinhui , Li Yongzheng , Shen Yong , Li Zhibo 
Published: November 2019

AbstractOrganocatalytic, metal‐free ring‐opening alternating copolymerization (ROAP) of epoxides and cyclic anhydrides to produce polyesters with well‐defined alternating structure remains a challenge despite several organocatalysts having been reported. Herein, the ROAP of cyclohexene oxide (CHO) with phthalic anhydride (PA) using a series of carboxylic acids as initiator in the presence of an organic cyclic trimetric phosphazene base (CTPB) as catalyst is reported. The molar ratio of CTPB to carboxylic acid is proven to be crucial to obtain polyester with well‐defined alternating structure without formation of polyether homopolymer. The effects of carboxylic acid, temperature and feed molar ratio on monomer conversions and resultant molecular weights of poly(PA‐alt‐CHO) are systematically investigated. This work enriches the opinion of initiator for the ROAP of epoxides and cyclic anhydrides.
Flame Retardancy and Mechanical Properties of Bio‐Based Furan Epoxy Resins with High Crosslink Density
Authors: Meng Jingjing , Zeng Yushun , Chen Pengfei , Zhang Jie , Yao Cheng , Fang Zheng , Ouyang Pingkai , Guo Kai 
Published: November 2019

AbstractThis work outlines an interesting approach to bioepoxy resins from sustainable 2,5‐bis((oxiran‐2‐ylmethoxy)methyl)furan (BOF). The 3,3′‐diamino diphenyl‐sulfone (33DDS) and 4,4′‐diamino diphenyl‐sulfone (44DDS) are employed as hardeners. For comparison, petro‐based networks from diglycidyl ether of bisphenol A (DGEBA) are developed as well. The systematic analyses suggest that the BOF/DDS networks show higher crosslink densities and mechanical properties than DGEBA/DDS thermosets. Remarkably, an attractive multilayer tubular microstructure is fabricated in the BOF/44DDS thermosets, and it greatly enhances the mechanical performance. Apart from that, BOF/DDS composites exhibit excellent flame retardancy. Especially, for BOF/44DDS, the self‐extinguishment happens in 7 s. The fire retardant mechanism confirms that a low heat release rate and heat release capacity as well as a compact char layer occur in the pyrolysis of BOF/DDS. Thus, the BOF/DDS exhibits superior performance over its DGEBA counterparts and meets a wide variety of requirements in engineering.
The Anterior Caudate Nucleus Supports Impulsive Choices Triggered by Pramipexole
Authors: Martinez Eva , Pasquereau Benjamin , Saga Yosuke , Météreau Élise , Tremblay Léon 
Published: November 2019

AbstractBackgroundPramipexole is a dopamine agonist used as a treatment in PD and restless legs syndrome to reduce motor symptoms, but it often induces impulse control disorders. In particular, patients with impulse control disorders tend to make more impulsive choices in the delay discounting task, that is, they choose small immediate rewards over larger delayed ones more often than patients without impulse control disorders and healthy subjects do. Yet the site of action of pramipexole that produces these impulsive choices remains unknown. Based on the heterogeneity of corticostriatal projections and the massive dopamine innervation of the striatum, we hypothesized that impulsive choices triggered by dopamine treatments may be supported by a specific striatal territory.OBJECTIVESThis study aims to determine by which anteriorstriatum territory the Pramipexole trigger impulsive choices; the caudate nucleus, the ventral striatum or the putamen.METHODSWe compared pramipexole intramuscular injections to intracerebral microinjections within the three striatal territories in healthy monkeys trained to execute the delay discounting task, a behavioral paradigm typically used to evaluate impulsive choices.RESULTSWe found that pramipexole intramuscular injections induced impulsive choices in all monkeys. Local microinjections were performed inside the anterior caudate nucleus, ventral striatum, and anterior putamen and reproduced those impulsive choices when pramipexole was directly injected into the caudate nucleus, whereas injections into the ventral striatum or putamen had no effect on monkeys’ choices.CONCLUSIONSThese results, consistent with clinical studies, suggest that impulsive choices triggered by pramipexole are supported by the caudate nucleus, allowing us to emphasize the importance of dopamine modulation inside this striatal territory in decision processes underlying impulsive behaviors. © 2019 International Parkinson and Movement Disorder Society