bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRPV2 activation reorganizes actin cytoskeleton, induces neurite initiation and branching by altering cAMP levels
Authors: Yadav Manoj , Goswami Chandan 
Published: October 2019

AbstractUnderstanding of molecules and their role in neurite initiation and/or extension is not only helpful to prevent different neurodegenerative diseases but also can be important by which neuronal damages can be repaired. In this work we explored the role of TRPV2, a non-selective cation channel in the context of neurite functions. Using western blot, immunofluorescence, and live cell Ca2+-imaging; we confirm that functional TRPV2 is endogenously present in the F11 cell, a model system mimicking peripheral neuron. In F11 cells TRPV2 localizes in specific sub-cellular regions enriched with filamentous actin, such as in growth cone, filopodia, lamellipodia and in neurites. TRPV2 regulates actin cytoskeleton and also interacts with soluble actin. Ectopic expression of TRPV2-GFP but not GFP-only in F11 cell induces more primary and secondary neurites, confirming its role in neurite initiation, extension and branching events. TRPV2-mediated neuritogenesis is dependent on wild-type TRPV2 as cells expressing TRPV2 mutants reveal no neuritogenesis. However, TRPV2-mediated neuritogenesis is unperturbed by the chelation of intracellular Ca2+ by BAPTA-AM, and thus involves Ca2+-independent signaling events also. We demonstrate that pharmacological modulation of TRPV2 alters cellular cAMP levels. These findings are relevant to understand the sprouting of new neurites, neuroregeneration and neuronal plasticity at the cellular, subcellular and molecular level. Such understanding may have border implication in neurodegeneration and peripheral neuropathy.
Interaction of Quercetin and Epigallocatechin Gallate (EGCG) Aggregates with Pancreatic Lipase Under Simplified Intestinal Conditions
Authors: Bustos Atma-Sol , Håkansson Andreas , Linares-Pastén Javier A. , Peñarrieta J. Mauricio , Nilsson Lars 
Published: October 2019

AbstractDiets rich in flavonoids have been related with low obesity rates, which could be related with their potential to inhibit pancreatic lipase, the main enzyme of fat assimilation. Some flavonoids can aggregate in aqueous medium suggesting that the inhibition mechanism could occur on both molecular and colloidal levels. This study investigates the interaction of two flavonoid aggregates, quercetin and epigallocatechin gallate (EGCG), with pancreatic lipase under simplified intestinal conditions. The stability and the morphology of these flavonoid aggregates were studied in four different solutions: Control (water), salt, low lipase concentration and high lipase concentration. Particles were found by optical microscopy in almost all the solutions tested, except EGCG-control. The results show that the precipitation rate decreases for quercetin and increases for EGCG in salt solution and that lipase stabilize quercetin aggregates. In addition, both flavonoids were shown to precipitate together with pancreatic lipase resulting in a sequestering of the enzyme.
How misconduct in business contributes to understanding the supply side of corruption in international business
Authors: Ertz Myriam , Karakas Fahri , Stapenhurst Frederick , Draman Rasheed , Sarigöllü Emine , Jo Myung-Soo 
Published: October 2019

Purpose
This study aims to offer a better understanding of supply side of bribery and corruption in an international business perspective by conceptualizing it in the narrower concept of misconduct in business (MIB) derived from the deontological perspective to business ethics.

Design/methodology/approach
The authors use a case study methodology of professionals working within Canadian mining multinational corporations operating in Africa. The authors conducted 2 focus groups, 25 in-depth interviews, document search and an open-ended questionnaire to 15 professionals. Further, they drew on a combination of the classic relationalist sociological framework and its recent revision, that they named the relationalism-substantialism framework to analyze the data.

Findings
The triangulated empirical data show that the reason why MIB in the form of bribery supply occurs is not exclusively tied to any given perspective, whether the individual, the organization or the wider societal context. Rather, these different layers are tightly intertwined and interact with each other for the supply of bribery to occur.

Originality/value
Although the three siloed perspectives of MIB have been studied in the literature, they have not been addressed in relation to one another, and even less with a relationalism-substantialism framework. Yet, this perspective contributes compellingly to the understanding of the supply side in bribery. The authors propose a net of conceptually related constructs that intervene in the process of bribery supply occurrence, namely relationality influenced by institutional dysfunctionality and conflation and substantiality through agency and culture.
Innovation and export performance: a meta-analytic review and theoretical integration
Authors: Bıçakcıoğlu-Peynirci Nilay , Hizarci-Payne Ayça Kubra , Özgen Özge , Madran Canan 
Published: October 2019

PurposeSince an accumulated body of research has examined the link between innovation and export performance and little attention has been paid to consolidate the existent fragmented findings in the pertinent literature, the purpose of this paper is to systematically integrate empirical findings based on a meta-analysis of relevant research investigating the association between innovation and export performance.Design/methodology/approachIn this research, correlations within individual studies were examined through performing a meta-analysis, which assists to synthesize the entire findings among past individual studies and helps to quantify the aggregated results. In total, 38 articles surveyed 554,227 exporting manufacturing companies were analyzed through a meta-analysis of 145 total effects.FindingsThis study demonstrates that innovation is a strategic source to achieve competitive advantage with intent to achieve superior performance in export markets. In this sense, the results reveal that while there is a significant relationship between innovation activities of companies and their export performance, export strategic performance dimension captures important facets in this relationship. Moreover, the results indicate that conceptualization of innovation and the development level of countries moderate the link between innovation and export performance. While output-oriented innovation is more influential on innovation-financial export performance association, the input-oriented innovation is more influential on strategic and market performance.Originality/valueThis present study attempted to synthesize fragmented results examining innovation–export performance link via revealing potential moderators on the association between innovation and export performance and providing important insights for both practitioners and scholars.
Bother me only if the client complains: control and resistance in home-based telework in India
Authors: Bathini Dharma Raju , Kandathil George Mathew 
Published: October 2019

Purpose
The purpose of this paper is to explore the link between operations of organization control and workers’ response to them in case of telework, a technology-embedded new way of working.

Design/methodology/approach
The authors adopted an interpretive approach to explore control and home-based teleworkers’ response in the Indian information technology industry. Interviews and non-participant observations were analysed using constructivist grounded theory.

Findings
The discourse of “telework as a privilege” served as a basis for normative control, helping managers exercise increased technocratic control. Combined with the discourse of “self-responsibility to client”, it led teleworkers to self-subjugate to long/unsocial work hours. However, the simultaneous exercise of technocratic and normative controls resulted in an inconsistency, creating space for teleworker’s resistance to technocratic control. Nonetheless, resistance to technocratic control ironically reinforced normative control.

Originality/value
The authors contribute to the recent discussion on compatibility and coherence of multiple control modes, and their relationship to resistance. The authors show how workers’ selves can be compatible with one control mode while being incompatible with other modes. The authors argue that when workers’ experience incoherence between control modes, they can appropriate the logic underlying compatible control mode(s) to resist incompatible control mode(s). Further, the authors demonstrate how resistance to incompatible control mode(s) can ironically reinforce compatible control mode(s), and thus explicate the micro-processes of control-resistance dialectic. Advancing the emergent understanding of resistance, the authors show that resistance is an exercise of strategic counter-power that seeks to exploit incoherence between control modes and inconsistencies between actions and rhetoric.
Pedagogical invention in entrepreneurship education
Authors: Verduijn Karen , Berglund Karin 
Published: October 2019

PurposeFollowing the example of the critical management education tradition, the purpose of this paper is to argue whether we should keep EE vital by disturbing it, in particular by interrogating that which has seemingly become “untouchable” from interrogation.Design/methodology/approachThis paper takes inspiration from Paolo Freire’s work by proposing a pedagogical approach to entrepreneurship education which builds on an iterative and interactive process, oscillating between deconstructing and reconstructing entrepreneurship, creating space for invention in the classroom. The paper provides exemplary contributions in developing suggestions as to ways forward.FindingsThe ways forward being proposed in this paper include entrepreneurship educators engaging students as co-learners, and evoking their curiosity to pose new questions about the phenomenon; “grounding” students in their own creativity and supporting them to build the confidence needed to develop alternative understandings of how entrepreneurship can function – for themselves, in their future organizations and for society as a whole; and challenging our own teaching positions, and adopting a pedagogical process of invention, stimulating curiosity, co-creation, thought-provoking questions and entrepreneurial action.Originality/valueThis paper provides ways forward in keeping EE “fresh”, by sketching how we need to teach about entrepreneurship, adopting the critical insights emerging in the field. The paper argues how we do not only need other models and approaches to understand entrepreneurship, but also to understand learning and education.
Organizational and human factors related challenges to ISO 20000
Authors: Ahmad Nafis , Rabbany Md Golam , Ali Syed Mithun 
Published: October 2019

Purpose
The purpose of this paper is to explore organizational and human factor-related challenges to information technology (IT) service management standard ISO 20000 in an emerging economy context. Then, this research has proposed some implications of the challenges to implementing environmental sustainability and circular economy.

Design/methodology/approach
To fulfill the research purpose, an empirical study was undertaken. The data required for the current study, based on a Likert scale and using questionnaires, were collected through surveys, interviews, telephonic conversations and meetings with IT firm managers and staff. The ranking of challenges was obtained based on the mean and standard deviation calculated from the survey responses.

Findings
The results indicated that senior management support was the most significant challenge for the successful implementation of IT Service Management systems. Other significant challenges were the justification of significant investment, premium customer support, co-operation and co-ordination among IT support teams, proper documentation and effective process design.

Practical implications
The current research is expected to help IT managers implement ISO 20000 and to manage environmental sustainability and circular economy across their organizational networks.

Originality/value
To the best of the authors’ knowledge, the current study is the first attempt to explore the organizational and human factor-related challenges to ISO 2000 in an emerging economy context. Furthermore, the current study proposes implications to the challenges to environmental sustainability and circular economy.
Internet of things adoption: a typology of projects
Authors: Ancarani Alessandro , Di Mauro Carmela , Legenvre Hervé , Cardella Marco Stefano 
Published: October 2019

PurposeThe internet of things (IoT) is one of the pillars of Industry 4.0. Prior OM research has conceptualized IoT, and analyzed potential applications and risks and challenges associated with its adoption. However, little empirical evidence exists on the main types of IoT projects undertaken by organizations and on their impacts. The purpose of this paper is to close this gap by searching for a taxonomy of IoT projects that may be associated to different IoT readiness levels. The dynamic capability lens is used as the theoretical background for the analysis.Design/methodology/approachA database of secondary IoT case studies is used to identify an IoT project taxonomy through two-step cluster analysis. The taxonomy obtained allows classifying projects into homogenous groups by technological novelty, IoT capabilities and functional areas of application. ANOVA is then used to test for the association between cluster membership and alternative operational impacts. Finally, the analysis of selected case studies from the database allows throwing light on the nature of the projects typical of each cluster.FindingsFive clusters of projects have been identified and positioned along varying degrees of capabilities, novelty and scope. The taxonomy is consistent with a three layer IoT technological readiness model. In turn, the three IoT readiness levels correspond to three managerial capabilities: monitoring, control and optimization. Combining cluster results with detailed case analysis suggests that IoT technological readiness can be interpreted as a dynamic capability enabling knowledge creation that can support competitive advantage.Originality/valueThis is a first attempt to describe projects firms undertake when adopting IoT. Building on cluster analysis, the study suggests that different IoT readiness levels are needed to reach different impacts.
Productivity of the Indian non-life insurance sector
Authors: Ilyas Ashiq Mohd , Rajasekaran S. 
Published: October 2019

Purpose
The purpose of this paper is to analyse the performance of the Indian non-life (general) insurance sector in terms of total factor productivity (TFP) over the period 2005–2016.

Design/methodology/approach
This study utilises Färe‒Primont index (FPI) to access the change in TFP and its components: technical change, technical efficiency and mix and scale efficiency over the observation period. Moreover, it employs the Mann–Whitney U-test to scrutinise the difference between the public and the private insurers in terms of growth in productivity.

Findings
The results reveal that the insurance sector possesses a very low level of TFP. Also, the results divulge an improvement of 11.98 per cent in TFP of the insurance sector at an annual average rate of 12.41 per cent over the observation period. The growth in productivity is mainly attributable to the improvement of 10.81 per cent in the scale‒mix efficiency. The progress in scale‒mix efficiency is mainly the result of improvements in residual scale and residual mix efficiency. The results also show that the privately owned insurers have experienced a high productivity growth rate than the state-owned insurers.

Practical implications
The results hold practical implications for the regulators, policymakers and decision makers of the Indian non-life insurance companies.

Originality/value
This study is the first of its kind to use FPI, which satisfies all economically relevant axioms and tests defined by the index number theory to comprehensively access the change in TFP of the Indian non-life insurance sector.
Impact of social support and presence on swift guanxi and trust in social commerce
Authors: Fan Jun , Zhou Wangyue , Yang Xue , Li Boying , Xiang Ying 
Published: October 2019

PurposeSwift guanxi and trust can influence consumers’ decision making in social commerce. What factors will influence the formation of swift guanxi and trust between buyers and sellers in social commerce has not been clearly investigated. The purpose of this paper is to identify antecedents and impacts of swift guanxi and trust in social commerce.Design/methodology/approachAn online questionnaire was used to collect the data, and Partial Least Squares Structural Equation Modeling was employed for data analysis. Social support and presence are introduced as the antecedents for swift guanxi and trust, leading to the repurchase intention (RI) and social sharing intention of customers.FindingsThe results indicate that social support and presence can influence swift guanxi and trust. Social support and presence are positively associated with swift guanxi and trust which further lead to RI and social sharing intention.Practical implicationsThe findings can be used to guide sellers in social commerce platforms to improve their services and make good use of platform features to improve customers’ perception of presence. To attract new customers and retain old customers, sellers should also build swift guanxi and trust through the recommendation and experience sharing of previous buyers on social media.Originality/valueThis study combines social support theory and presence theory to investigate the factors that influence customers’ purchase decision and social sharing intention in the context of social commerce in China. The integration of social support theory and presence theory explains both the social and technical factors that influence swift guanxi and trust in social commerce.
Evaluating the effect of new working practices on office space usage in Hong Kong
Authors: Jayantha Wadu Mesthrige , Oladinrin Olugbenga Timo 
Published: October 2019

PurposeMany organizations in Hong Kong have witnessed a reduction in average space usage due to high occupancy costs. New working practices (NWPs) are viewed as a reform tool to manage expensive real estate around the world. However, it is unclear whether NWPs influence office space usage in business organizations in Hong Kong. This study, therefore, aims to evaluate if the average space reduction in office firms is caused by the NWPs in the finance, insurance, real estate and business (FIREB) firms.Design/methodology/approachA total of 20 NWPs were initially derived from the extant literature. A questionnaire survey was conducted with listed FIREB firms in Hong Kong to assess the impact of the identified NWPs on space usage. The data collected from the questionnaire survey were analysed using descriptive, explorative factor analysis (EFA) and partial least squares-structural equation modelling (PLS-SEM) to evaluate the effects of NWPs on average space usage.FindingsResults revealed that four major NWP factors influence average space usage. Three of these factors, namely, “flexible arrangement”, “multitasking knowledge workers” and “teamwork and communication”, influence space usage positively. Even though the effect of the fourth factor “training and networking” was significant, it does not reflect a positive influence on space usage. Business organizations can focus more on the implementation of NWPs to cushion the effects of the high cost of occupancy.Originality/valueThe research provides new knowledge to the limited literature on the effect of NWPs in FIREB firms and enriches the growing body of international literature on how today’s competitive global business organizations should revisit their workplace strategies to accommodate the rising agile workforce and NWPs. The findings offer new insights into the ongoing debate on the impact of information and communication technology-enabled NWPs on space usage. From the real estate perspective, the findings should inform policymaking towards the better planning ahead of office properties to accommodate NWPs, helping Hong Kong to remain competitive as a key financial centre.
Qualification mismatch in the labor market and the impact on earnings: evidence from Vietnam
Authors: Quang Huy Le , Tran-Nam Binh 
Published: October 2019

PurposeThe purpose of this paper is to investigate the incidence and earning effects of the vertical mismatch between attained and required educational qualifications in a developing country’s labor market.Design/methodology/approachFollowing Duncan and Hoffman (1981), this paper uses the augmented Mincerian wage equation to decompose the actual years of education of a person into years of over-education, years of required education and years of under-education. These years of education are then fitted in an ordinary least squares model to measure the earning effects of an employee when his/her attained educational qualifications are higher or lower than the required educational level in his/her job.FindingsUnlike studies in developed countries, this paper finds that Vietnam has a higher incidence of under-education than over-education due to a large proportion of the population in rural and remote areas not having access to formal education. Further, qualification mismatch has an asymmetric effect on earnings in the sense that the wage rate is flexible downward but rigid upward. In particular, years of schooling that are in excess or in deficit of the required level for the job are not compensated with higher earnings. This paper concludes that although qualification mismatch incidence in Vietnam is different from that in developed countries, mismatched workers also suffer from significant wage penalty.Originality/valueThis paper makes a significant contribution by providing the first evidence from a developing country to the vertical mismatch literature which has already been overwhelmed with studies from advanced economies.