bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interferon Regulatory Factor‐5 in Resident Macrophage Promotes Polycystic Kidney Disease
Authors: Zimmerman Kurt A. , Huang Jifeng , He Lan , Revell Dustin Z. , Li Zhang , Hsu Jung-Shan , Fitzgibbon Wayne R. , Hazard E. Starr , Hardiman Gary , Mrug Michal , Bell P. Darwin , Yoder Bradley K. , Saigusa Takamitsu 
Published: March 2020

Background
Autosomal dominant polycystic kidney disease is caused by genetic mutations in PKD1 or PKD2. Macrophages and their associated inflammatory cytokines promote cyst progression; however, transcription factors within macrophages that control cytokine production and cystic disease are unknown.

Methods
In these studies, we used conditional Pkd1 mice to test the hypothesis that macrophage-localized interferon regulatory factor-5 (IRF5), a transcription factor associated with production of cyst-promoting cytokines (TNFα, IL-6), is required for accelerated cyst progression in a unilateral nephrectomy (1K) model. Analyses of quantitative real-time PCR (qRT-PCR) and flow-cytometry data 3 weeks post nephrectomy, a time point before the onset of severe cystogenesis, indicate an accumulation of inflammatory infiltrating and resident macrophages in 1K Pkd1 mice compared with controls. qRT-PCR data from FACS cells at this time demonstrate that macrophages from 1K Pkd1 mice have increased expression of Irf5 compared with controls. To determine the importance of macrophage-localized Irf5 in cyst progression, we injected scrambled or IRF5 antisense oligonucleotide (ASO) in 1K Pkd1 mice and analyzed the effect on macrophage numbers, cytokine production, and renal cystogenesis 6 weeks post nephrectomy.

Results
Analyses of qRT-PCR and IRF5 ASO treatmentsignificantly reduced macrophage numbers, Irf5 expression in resident—but not infiltrating—macrophages, and the severity of cystic disease. In addition, IRF5 ASO treatment in 1K Pkd1 mice reduced Il6 expression in resident macrophages, which was correlated with reduced STAT3 phosphorylation and downstream p-STAT3 target gene expression.

Conclusions
These data suggest that Irf5 promotes inflammatory cytokine production in resident macrophages resulting in accelerated cystogenesis.
PENGARUH PROFITABILITAS (ROA), LEVERAGE (LTDER) DAN INTENSITAS AKTIVA TETAP TERHADAP PENGHINDARAN PAJAK (TAX AVOIDANCE) PADA PERUSAHAAN SUBSEKTOR MAKANAN DAN MINUMAN YANG TERDAFTAR DI BEI PERIODE 2015-2017
Authors: Jamaludin Ali 
Published: March 2020

This study aims to analyze the effect of Profitability (ROA), Leverage (LTDER), and Intensity of Fixed Assets Against Tax Avoidance. The population in this study were all food and beverage subsector companies listed on the Indonesia Stock Exchange (BEI) in 2015-2017, namely 18 companies. Data collection using purposive sampling method and based on predetermined criteria, the number of samples obtained were 12 food and beverage sub-sector manufacturing companies listed on the Stock Exchange during the 2015-2017 period. The data analysis method used is the panel data regression analysis method.
The results showed that: 1) Profitability (Return On Assets) had a negative and not significant effect on Tax Avoidance, 2) Leverage (Long Term Debt to Equity Ratio) had no effect on Tax Avoidance, 3) CapitL Intensity had no effect on Tax Avoidance.
PENGARUH GREEN MARKETING DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN PRODUK ORIFLAME PURWAKARTA
Authors: Mawardi Amna 
Published: March 2020

The Research aimed to determine factors that influencing the purchase decision of oriflame’s product. This research was take in two variables that affect the decision to purchase the green marketing (X1) and Product Quality (X2). Data collection using non-probability technique and the kind of the purposive sampling spread at les 100 respondents in Purwakarta that are active and ever of Oriflame’s consumer products. The research analyzed through the software SPSS 22.
The outcome of this research, in partial such green marketing and the product quality have had a significant positive impact of the purchase decision. The whole dependent variable simultaneously influence of the purchase decision with F value count 55,587 and the economic situation of significant 0,000 < 0.05. R square value showed the results of 0,534 having meaning that whole of dependent variable influential simultaneously as many as 53,4 %.
ANALISIS TINGKAT KESEHATAN BANK MENGGUNAKAN METODE PROFIL RISIKO, TATA KELOLA PERUSAHAAN YANG BAIK, PENDAPATAN & MODAL (Studi Komparasi Antara Bank Umum Konvensional dan Bank Umum Syariah Di Indonesia Lemabaga yang Terdaftar Pada Otoritas Layanan Keuangan
Authors: Manda Gusganda Suria , Hendriyani Rina Maria 
Published: March 2020

This analysis aims to find out, analyze and explain how the bank's soundness level compares with the Risk Profile, Good Corporate Governance, Earning and Capital methods in accordance with applicable regulations.
This research was conducted using a comparative descriptive method with a quantitative approach.
The results of the analysis of this study the authors get that Conventional Commercial Banks have a Risk Profile (NPL ratio) with a rating of "Good" better than a Sharia Commercial Bank with a rating of "Fairly Good". Conventional Commercial Banks have a Risk Profile (LDR) higher than Islamic Commercial Banks with a rating of "Fairly Good". Conventional Commercial Banks have Good Corporate Governance (GCG) better than Sharia Commercial Banks with a "Good" rating. Conventional Commercial Banks have better Earning (ROA) with a "Very Good" rating than a Sharia Commercial Bank with a "Very Poor" rating. Sharia Commercial Banks have a Capital (CAR) higher than Conventional Commercial Banks with a rating of "Very Good
Economic Models of Mongolia and Vietnam: Common and Distinctive Features
Authors: Nguyen Quoc Hunga , Lezhenina T. V. 
Published: March 2020

New economic models began to develop in Mongolia and Vietnam after the collapse of the Union of Soviet Socialist Republics (USSR), when former Soviet republics formed the Commonwealth of Independent States (CIS). Further development after the USSR’s dissolution was especially difficult for Mongolia, which almost entirely relied on the economic aid from the USSR. The US and the International Monetary Fund (IMF) immediately took advantage of the crisis in Mongolia. They offered tranches to Mongolia under the condition of complete democratization of political power and establishment of market-based development institutions within the framework of a standby arrangement. Vietnam embarked on a course of destroying the socialist model in 1986, i.e. before the USSR’s collapse, and its transition to a market economy was peculiar, yet significantly different from Mongolia’s.Aim. The presented study aims to examine the benefits and drawbacks of the economic models of Vietnam and Mongolia as well as their common and distinctive features.Methods. The study uses general methods of analyzing the international experience of transforming economic models.Results. The authors prove the efficiency of the current Mongolian and Vietnamese models in the context of global instability and crises. Emergence of new, highly efficient technological paradigms and absence of internal political protests in Mongolia and Vietnam ensure economic sustainability and high growth rate. Russia’s military aid to these countries also plays an important role.Conclusions. After the collapse of the Soviet Union, Mongolia received substantial assistance from the United States and was able to maintain state independence and develop its economy under the market conditions of economic activity. Relying on cooperation with Russia and China, in the 21st century Mongolia engaged in the processes of integration in the Asia-Pacific region (APR). The Vietnamese model was forming during the country’s participation in the ASEAN free trade zone and cooperation with the developed economies of Japan, the Republic of Korea, and the United States. Unlike Mongolia, Vietnam retained full political leadership of the Communist party, the unity of its people, and support for the development of market economy. In confronting difficult challenges, Vietnam receives assistance from the Donor Club.
The Effect of Flipped Classroom technique on Iraq EFL Students’ Achievement in Learning Adjectives
Authors: Salal Assi. Prof. Saad , Ali Assi. Instr. Bilal 
Published: March 2020

The current study aimed at investigating the effect of flipped classroom technique on Iraq EFL students’ achievement in learning adjectives.
The sample of the current study was 3rd grade students from the English Department at the college of Basic Education/ Al-Mustansiriyha University.
To filful the aim of the study, the researcher adopted a null hypothesis which indicates that there was no significant difference between students’ achievement that used a new technique in learning adjectives of that do not use. To achieve the aim of the current study an eight weeks experiment was conducted on the experimental group with pre and posttest. The experiment was started on 11 October and ended in 11th January, 2017.
At the end of the experiment, the researcher has used t-test for two groups and he submitted the form of the test to experts to ensure its validity and reliability, the calculated results had shown that there was a statistically significance difference between the achievement of the students of the experimental group on the posttest from control group. Finally, the researcher had put down some conclusions, recommendations and suggestions for further research.
MODELLING OF THE ELECTROMAGNETIC FIELDS CREATED BY COMPACT MULTI SEGMENT POWER LINES
Authors: Buyakova Natal'ya , Zakaryukin Vasiliy , Kryukov Andrey , Le Van 
Published: March 2020

In the article analysis technique of electromagnetic safety conditions on routes of
compact power lines (CPL) is offered. As the tool the program complex Fazonord was applied to modeling of CPL modes and electromagnetic fields.
Results of modeling show that the average levels of CPL electric field strengths exceed a similar indicator for the standard power line by 25…145 %, distinctions of maximums lie within 7… 150 %.
Especially considerable strength excesses take place at three-segment CPL. By criterion of magnetic
field strength the return picture is observed: levels of CPL magnetic field strength on 70 … 90 % below
than in traditional power line, and the best picture of electromagnetic safety possesses the foursegment power line.
SOCIOCULTURAL SPLIT AND RADICALIZATION OF SOCIETY IN THE SECOND HALF OF THE NINETEENTH CENTURY
Authors: Savchuk Natal'ya 
Published: March 2020

The article discusses the causes of the sociocultural contradictions that led to the
radicalization of society and the emergence of terrorist revolutionary organizations in the second half
of the 19th century. The social structure of society is considered. The danger of underestimating society propaganda of extremist ideas of revolutionaries is shown.
Utilization Of Ted Talks Videos In Facilitating The Lessons In Social Science: Adult Learners In Focus
Authors: Gregoria Robles Concepcion Maria 
Published: March 2020

With the advancement of technology, teachers are challenged on how they could cope with the academic needs of their students - understanding the lessons in class. This qualitative study focused on the adult learners’ experiences on how TED Talks Videos enhanced their understanding of the lessons and gathered their views on how the utilization of the strategy be improved. Results revealed that the students generally like the speakers’ professionalism and expertise. However, the length of the videos hindered students’ interests and understanding. Moreover, the participants mentioned that the videos’ factual information and contextual examples helped them understand the lesson well. They also found the subject teachers’ additional explanation on the topic was beneficial. They suggested that background information may be given before the videos may be presented. Variant answers, conclusion, and implications were also presented.
Nilai-Nilai Pendidikan Multikultural dalam Mata Pelajaran Aswaja dan ke-NU-an Siswa SMP/MTs
Authors: Bukhori Imam 
Published: March 2020

Aswaja and NU's Education taught in Nahdlatul Ulama educational institutions, especially for junior high school / MTs are directed to maintain, preserve, develop and practice Ahlu al-Sunnah Wal Jama'ah Islam teachings and conduct activities aimed at to create the benefit of society, the progress of the nation and the height of human dignity and dignity that can be understood very in tune with the values of multicultural education. The values of multicultural education include: (1) the value of democracy, equity and justice; (2) the value of humanity, togetherness, and peace; and (3) social attitudes, namely: recognition, acceptance and appreciation to others is very appropriate and all of which are covered in Aswaja and NU's educational content for junior high school / MTs, ie al-ta'awun, al-tawasuth, al-i'tidal, al-tasamuh, al-tawazun, and amar ma'ruf nahi munkar, and ukhuwah baikukhuwah nahdliyah, islamiyah, wathaniyah, basyariyah and then embodied in the form of mabadi 'khaira ummat which originated from al-shidqu norm, al -aahah wa al-wafa bi al-'ahdi, al-'adalah, al-ta'awun and al-istiqamah.Hal affirms that the practice of Aswaja and NU's education is taught in educational institutions within the organization Nahdlatul Ulama very inclusive. Internally, education in Nahdlatul Ulama 'organization has been proven to have introduced multicultural values to its students both in terms of doctrine of the teachings, as well as in terms of the daily life experiences of the students. Externally, these multicultural values are also socialized and made into principles in establishing social relationships with communities and other groups outside Nahdlatul Ulama's educational institutions'.
Keywords: Values of Multicultural Education, Aswaja Subjects and Nuns, SMP / MTs.
Strategi Pendidikan Agama Islam dalam Meningkatkan Kualitas Kepribadian Siswa di MTs Negeri Probolinggo
Authors: Hamid Abdul 
Published: March 2020

Education has always sought to provide guidance to students to establish and develop science and personality intact. The importance of improving the quality of education for students, and based on the term that education is as one program that can prepare and predict the development of students in the future, then, some efforts should be made by the Islamic educational institutions. In this case, MTs Probolinggo is one that should be oriented to achieve the quality of personality to development and prepare future generations who are ready to face the globalization era. In achieving this goal, the Islamic religious education in particular must have the correct strategy and precise in its development.Based on the reality happened in MTs Probolinggo, the learning of Islamic religious education in schools had been running in precise. But Islamic religious education especially MTs Probolinggo this should be taken to ensure that students not only can learn by heart religious lessons, but also able to be affective and behavioral. It is evident that in the previous year students MTs Probolinggo one has a moral decline that is one of the students exposed to cases of liquor. But it can be solved by getting serious handlers by the school so that the good name of MTs Probolinggo back brilliantly.From the background of the above problems, the researcher is motivated to conduct the research on the strategy of Islamic religious education in improving students' personalities in MTs Probolinggo. The focal points of this study are: (1) how is the steps of learning Islamic religious education in improving the quality of students' personalities in MTs Probolinggo?; (2) how is the implementation of learning Islamic religious education in students personality development in MTs Probolinggo?.The objectives in this study are: (1) to describe the steps of learning Islamic religious education in improving the quality of students' personalities in MTs Probolinggo; (2) to describe the implementation of learning Islamic education in improving the quality of students' personalities in MTs Probolinggo.Based on the data obtained and the result of this research, it can be can be summarized as follows: The first steps of learning Islamic education in improving the quality of students' personalities in the MTs Probolinggo can be quite good. Teachers of Islamic religious education in MTs Probolinggo has taken steps learning through teacher's council of Islamic religious education lessons, ranging from the preparation of the appropriate standard of syllabus content, standard competence and guide the preparation curriculum KTSP; make analysis today effective; effective last analysis; annual program; term program and lesson plan.
Keywords: Islamic education strategy, Improving the quality of student personality
Pengetahuan Ibu Menyusui Dalam Pemberian ASI Eksklusif
Authors: Tendean Angelia Friska 
Published: March 2020

ABSTRACT
Exclusive breastfeeding is highly recommended for infants aged 0-6 months, where the content of breast milk is in accordance needed by the baby. The research method used descriptive analytic with the cross sectional approach. The purpose of this study was to determine the relationship between knowledge of nursery mothers and exclusive breastfeeding in the working area of ​​the Airmadidi health center. The research sample consisted 34 breastfeeding mothers of infants aged 6-24 months in the working area of the Airmadidi health center. The results obtained were 11 respondents (16.2%) had good knowledge and 11 respondents (16.2%) also had sufficient knowledge, where 21 respondents (61.8%) did not provide exclusive breastfeeding and 13 respondents (38 , 2%) give exclusive breastfeeding. The last education that had good knowledge was D3 / Bachelor 7 respondents (58.3%) and those who gave the most exclusive breastfeeding were high school as many as 9 respondents (56.3%). Based on the number of children who have better knowledge are primipara 8 respondents (53.3%), and those who give the most exclusive breastfeeding are multiparas 7 respondents (41.2%). The results of statistical tests using Pearson Correlation found p = 0.008 <0.05, that meaning there was a significant relationship between the knowledge of nursery mothers and exclusive breastfeeding. The results of statistical tests using Partial Correlation showed that there was a significant relationship between knowledge of breastfeeding mothers and exclusive breastfeeding if the education status and parity factors were included with the value p = 0.018 <0.05 for education status and p = 0.005 <0.05 for parity. Good knowledge will influence the behavior of nursery mothers on exclusive breastfeeding.
Diaphragmatic Breathing Exercise And Blood Pressure Of Prehipertensive Clients At Universitas Advent Indonesia
Authors: Sinaga Giovanni M , Malinti Evelin 
Published: March 2020

ABSTRAK
Peningkatan tekanan darah adalah suatu kondisi progresif. Studi pendahuluan menunjukkan bahwa mahasiswi Universitas Advent Indonesia ada potensi untuk mengalami peningkatan tekanan darah. Penelitian ini bertujuan untuk menginvinvestigasi efek dari diaphragmatic breathing exercise pada tekanan darah klien prehipertensi. Penelitian ini menggunakan desain pre experimental dengan jenis one group pretest posttest. Populasi peneletian adalah mahasiswi keperawatan yang tinggal di asrama putri Universitas Advent Indonesia. Responden dipilih dengan teknik purposive sampling. Sebanyak 17 responden yang memenuhi kriteria inklusi dan menandatangani informed consent. Responden diajarkan cara melakukan diaphragmatic breathing exercise dan melakukannya sebanyak 3 siklus. Tekanan darah sistol dan diastol diukur sebelum dan sesudah melakukan diaphragmatic breathing exercise. Rata- rata tekanan darah sebelum melakukan diaphragmatic breathing exercise dikategorikan sebagai prehipertensi. Rata- rata tekanan darah setelah melakukan diaphragmatic breathing exercise dikategorikan normal. Hasil uji t-berpasangan menunjukkan bahwa ada perbedaan signifikan (p value < .05) pada tekanan darah baik sistol maupn diastol sebelum dan sesudah diaphragmatic breathing exercise. Saran bagi penelitian selanjutnya adalah mengembangkan penelitian ini dengan jumlah responden yang lebih besar pada pasien hipertensi dengan mengukur tekanan darah dan nadi .
Kata kunci: Diaphragmatic Breathing Exercise, Tekanan Darah, Prehipertensi
Fenomena Merokok Pada Anak Usia Remaja: Studi Kualitatif
Authors: Elon Yunus , Malinti Evelin 
Published: March 2020

Abstrak

Merokok dikalangan remaja merupakan salah satu fenomena yang cukup memprihatinkan. Peringatan bahaya merokok yang terdapat pada bungkus rokok tidak memberikan pengaruh yang signifikan dalam mengurangi jumlah perokok dan bahkan sebaliknya jumlah perokok terus meningkat. Tujuan yang hendak dicapai dalam penelitian ini adalah: untuk mendeskripsikan gambaran merokok pada anak usia remaja. Metode yang digunakan pada penelitian ini adalah metode kualitatif dengan tehnik accidental sampling. Informan yang digunakan dalam penelitian ini berjumlah 10 orang pelajar SMP yang berdomisili di kecamatan Parongpong. Hasil penelitian menunjukkan fenomena merokok pada anak usia remaja antar lain: alasan remaja merokok; coba-coba, sahabat, orang tua, iseng-iseng dan ketagihan. Hal-hal yang dirasakan saat pertama kali merokok antara lain; pahit, batuk, ketagihan/kecanduan, kebiasaan, keterusan, pusing, tidak enak, nyesel dan tenggorokan kering. Pandangan informan tentang seseorang yang merokok antara lain: macho/keren, gaul, percaya diri, dan jelek. Respon orang tua, guru dan teman saat informan merokok yaitu: marah, melarang, dihukum, ngajakin. Waktu yang biasa digunakan oleh informan untuk merokok: saat berkumpul bersama teman, sehabis makan dan cuaca dingin. Tanggapan tentang merokok saat ini; dinikmati dan enak. Hasil penelitian ini diharapkan dapat menjadikan referensi untuk melakukan penelitian tentang status merokok dalam hubungan dengan kualitas hidup di kalangan remaja.

Kata kunci: Fenomena, Merokok; Remaja;
Hubungan BMI Dengan Kadar Gula Darah Pada Wanita Dewasa Di Desa Cihanjuang Rahayu
Authors: Riris Okno , Elon Yunus 
Published: March 2020

Abstrak

Body Mass Index (BMI) merupakan gambaran dari tingkat keidealan tubuh seseorang. Sehingga peningkatan BMI menjadi salah satu indikator dalam menentukan status kesehatan seseorang. Mereka yang memiliki BMI yang tinggi menunjukkan bahwa mereka memiliki kelebihan berat badan atau obesitas dan beresiko menderita hypertensi, diabetes meletus type 2, jantung, stroke, kolesterol dan kanker. .obesitas dapat mengakibatkan meningkatnya kadar gula darah. Tujuan penelitian ini adalah menentukan hubungan BMI dengan kadar gula darah puasa pada wanita dewasa. Jenis penelitian ini menggunakan Cross sectional study, yang merupakan penelitian observasional yang bersifat analitik terhadap 45 responden wanita dewasa dengan batasan umur 26-45 tahun. Hasil analisis bivariate menunjukkan usia 36-45 tahun sebesar 53,3%, 26-35 tahun 46,7%; rata-rata pendidikan SD=44,4%. SMP 44,4% dan SMA 11,1%. BMI diatas normal sebanyak 73.3% dan normal 26,7%. Sedangkan gula darah 91,1% normal, dan 4,4% tinggi serta 4,4% rendah. Hasil analisis univariate Pearson Product-Moment Correlation .023 dengan p-value = >.05. Hasil analisa penelitian ini menunjukan bahwa tidak ada hubungan yang bermakna antara BMI terhadap kadar gula darah puasa pada wanita dewasa. Untuk mendapatkan gambaran yang menyeluruh maka, penelitian selanjutnya tentang hubungan BMI dengan kadar gula darah puasa perlu dilakukan pada berbagai kelompok usia, serta melibatkan kedua jenis kelamin.

Kata Kunci: Indeks Massa Tubuh, Obesitas, Kadar Gula Darah Puasa