bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigação-ação com mães de pessoas com deficiência intelectual: a redução da sobrecarga como um projeto de vida
Authors: Fonseca Sarah Cecílio , Carvalho-Freitas Maria Nivalda de , Alves Beatriz André 
Published: July 2020

O artigo tem por objetivo relatar investigação-ação realizada com grupos de mães de pessoas com deficiência intelectual, visando contribuir para a melhoria na qualidade de vida e na ressignificação de seus projetos de vida. A investigação-ação foi realizada com dois grupos, sendo que em um deles realizou-se 24 encontros durante oito meses, e, no outro, foram realizados 12 encontros durante quatro meses. Foram registrados todos os encontros, através de observações sistemáticas, e realizada a análise de conteúdo e dos principais fenômenos grupais, além de avaliação da percepção de mudança após finalização da experiência. No início da pesquisa, observou-se resistência por parte das mães em relação ao tema projeto de vida como consequência de dificuldades pouco trabalhadas em relação à capacidade de seus filhos. Isto é, observou-se que as mães ofereciam poucas possibilidades de seus filhos desenvolverem autonomia e independência para atividades da vida diária, causando sobrecarga às mesmas, enquanto cuidadoras. Assim, o foco da investigação-ação foi discutir sobre atividades concretas que pudessem gerar autonomia, considerando os limites e as possibilidades dos filhos e questões relacionadas às vivências subjetivas das mães, tendo como disparador o Inventário de Habilidades de Vida Independente. Verificou-se que a reflexão sobre atividades diárias dos filhos, sobre formas de estimulação para maior independência e sobre estratégias que poderiam ser utilizadas para o filho desenvolver determinado comportamento, além de reduzir a sobrecarga, constitui-se em um projeto de vida para as mães.
Medidas socioeducativas y colaboración interprofesional: entre tensiones y nuevas estructuras profesionales.
Authors: Blaya Catherine , Allenbach Marco , Angelucci Valérie , Rebetez Frédérique 
Published: July 2020

Este artículo trata de la aparición del trabajo socioeducativo en el ámbito escolar para prevenir el abandono escolar en Suiza (cantón[1] de Vaud). El termino "socioeducativo" se aplica conjuntamente a una serie de situaciones problemáticas recientes, nuevos dispositivos o profesionales adecuados designados para responder a ellas y, también una nueva manera de nombrar algunas de sus actividades. Focus groups que asocian diferentes colaboradores profesionales y luego docentes han permitido investigar sus representaciones del trabajo socioeducativo, comprender los desafíos establecidos e identificar algunas condiciones para que los recursos y estrategias movilizados contribuyan al apoyo de los alumnos en dificultad.
Los resultados muestran que el término “socioeducativo” se puede utilizar para designar diversos ámbitos de actuación considerando cada uno de ellos como perteneciente, tanto a las tareas de los docentes, como a otras competencias profesionales. El trabajo socioeducativo aparece como representativo de la relación interprofesional ya que supone un campo de actividad al que contribuye el conjunto de la comunidad educativa.

[1] Se denomina cantón a cada una de las regiones suizas con gobierno autónomo y capitalidad. La capital del cantón d Vaud es Lausana. (Nota de traducción)
Introduction: this article aims to investigate the emergence of socio-educational work in the school context in order to prevent early school leaving in Switzerland (Canton of Vaud). The term “socio-educational” is used jointly to refer to problematic situations and resources or professionals devoted to addressing such situations. Finally, the term is also used to refer to certain activities beyond teaching. Method: seven focus groups including specific professionals and teachers were surveyed (i) to conceptualize their representations of socio-educational work; (ii) to define perceived challenges; and (iii) to identify conditions which foster the support of disadvantaged children. Findings: the results show that the term "socio-educational" can be used to designate various types of activities which, sometimes, are related to teaching and, some other times, to other professional skills. Socio-educational work seems to represent interprofessional relationships in that it involves the whole educational community.
Estudio piloto de variables socio-emocionales, ansiedad y flow en alumnos de grado profesional de música mediante actividades BAPNE
Authors: Moral Bofill Laura , Vicedo Molla Francisco , Romero Naranjo Francisco Javier 
Published: July 2020

El objetivo de esta investigación es hacer un análisis exploratorio a través de un diseño cuasi-experimental con grupo control no equivalente de los efectos que las actividades del método BAPNE tienen sobre las emociones, la ansiedad, el “flow” y la conducta social en alumnos de Grado Profesional de Música. Los resultados obtenidos apoyan nuestras hipótesis de investigación con diferencias estadísticamente significativas en medidas pre-post del grupo experimental con p< .05 para emociones, ansiedad-estado y flow. Sugiriendo que las actividades BAPNE favorecen las emociones agradables, disminuyen la ansiedad estado y generan una experiencia alta de flow. Para la conducta social, sin embargo, no se han detectado cambios significativos en las medidas tomadas con el cuestionario BAS3.
Adoptant un modèle quasi-expérimental avec un groupe témoin non-équivalent, cette recherche conduit une analyse exploratoire des effets que les activités de la méthode BAPNE ont sur les émotions, l'anxiété, le “flow” et le comportement social chez les étudiants en musique. Les résultats obtenus soutiennent notre hypothèse de recherche avec des différences statistiquement significatives dans les mesures pré-post du groupe expérimental avec p < .05 pour les émotions, l'anxiété état et le flow. Ils suggèrent que les activités de BAPNE favorisent les émotions agréables, diminuent l'anxiété état et génèrent une expérience élevée de flow. Pour le comportement social, cependant, aucun changement significatif n'a été détecté dans les mesures prises avec le questionnaire BAS3.
First report of begomoviruses infectingCucumis sativusL. in North America and identification of a proposed new begomovirus species
Authors: Sanchez-Chavez Sarahi , Regla-Marquez Carlos Fernando , Cardenas-Conejo Zugey Elizabeth , Garcia-Rodriguez Daniel Alejandro , Centeno-Leija Sara , Serrano-Posada Hugo , Liñan-Rico Andromeda , Partida-Palacios Brenda Lizet , Cardenas-Conejo Yair 
Published: July 2020

BackgroundMembers of theBegomovirusgenus are phytopathogens that infect dicotyledonous plants, producing economic losses in tropical and subtropical regions. To date, only seven species of begomoviruses (BGVs) infecting cucumber have been described. Most cucumber infections were reported in South Asia. In the Americas, begomoviral infections affecting cucumber are scarce; just one report of begomovirus has been described in South America. The presence of whitefly and typical symptoms of viral infections observed in a cucumber field in Colima, Mexico, suggested that plants in this field were affected by BGVs.MethodsTo identify the BGVs infecting cucumber, we performed a high-throughput sequencing and compared the assembled contigs against the GenBank nucleic acid sequence database. To confirm the presence of viruses in cucumber samples, we performed a PCR detection using specific oligonucleotides. We cloned and sequenced by Sanger method the complete genome of a potential new begomovirus. Begomovirus species demarcation was performed according to the International Committee on Taxonomy of Viruses. The evolutionary relationship of the new virus was inferred using phylogenetic and recombination analyses.ResultsWe identified five species of begomovirus infecting plants in a field. None of these have been previously reported infecting cucumber. One of the five species of viruses here reported is a new begomovirus species. Cucumber chlorotic leaf virus, the new species, is a bipartite begomovirus that has distinctive features of viruses belonging to the squash leaf curl virus clade.ConclusionsThe findings here described represent the first report of begomoviral infection affecting cucumber plants in North America. Previous to this report, only seven begomovirus species have been reported in the world, here we found five species infecting cucumber plants in a small sample suggesting that cucumber is vulnerable to BGVs. One of these viruses is a new species of begomovirus which is the first begomovirus originally isolated from the cucumber. The findings of this report could help to develop strategies to fight the begomoviral infections that affect cucumber crops.
Arthropod IGF, relaxin and gonadulin, putative orthologs of Drosophila insulin-like peptides 6, 7 and 8, likely originated from an ancient gene triplication
Authors: Veenstra Jan A. 
Published: July 2020

Background
Insects have several genes coding for insulin-like peptides and they have been particularly well studied in Drosophila. Some of these hormones function as growth hormones and are produced by the fat body and the brain. These act through a typical insulin receptor tyrosine kinase. Two other Drosophila insulin-like hormones are either known or suspected to act through a G-protein coupled receptor. Although insulin-related peptides are known from other insect species, Drosophila insulin-like peptide 8, one that uses a G-protein coupled receptor, has so far only been identified from Drosophila and other flies. However, its receptor is widespread within arthropods and hence it should have orthologs. Such putative orthologs were recently identified in decapods and have been called gonadulins.

Methodology
In an effort to identify gonadulins in other arthropods public genome assemblies and short-read archives from insects and other arthropods were explored for the presence of genes and transcripts coding insulin-like peptides and their putative receptors.

Results
Gonadulins were detected in a number of arthropods. In those species for which transcriptome data from the gonads is available insect gonadulin genes are expressed in the ovaries and at least in some species also in the testes. In some insects differences in gonadulin expression in the ovary between actively reproducing and non-reproducing females differs more than 100-fold. Putative orthologs of Drosophila ilp 6 were also identified. In several non-Dipteran insects these peptides have C-terminally extensions that are alternatively spliced. The predicted peptides have been called arthropod insulin-like growth factors. In cockroaches, termites and stick insects genes coding for the arthropod insulin-like growth factors, gonadulin and relaxin, a third insulin-like peptide, are encoded by genes that are next to one another suggesting that they are the result of a local gene triplication. Such a close chromosomal association was also found for the arthropod insulin-like growth factor and gonadulin genes in spiders. Phylogenetic tree analysis of the typical insulin receptor tyrosine kinases from insects, decapods and chelicerates shows that the insulin signaling pathway evolved differently in these three groups. The G-protein coupled receptors that are related to the Drosophila ilp 8 receptor similarly show significant differences between those groups.

Conclusion
A local gene triplication in an early ancestor likely yielded three genes coding gonadulin, arthropod insulin-like growth factor and relaxin. Orthologs of these genes are now commonly present in arthropods and almost certainly include the Drosophila insulin-like peptides 6, 7 and 8.
Correlated Electrical and Chemical Nanoscale Properties in Potassium‐Passivated, Triple‐Cation Perovskite Solar Cells
Authors: Tennyson Elizabeth M. , Abdi‐Jalebi Mojtaba , Ji Kangyu , Garrett Joseph L. , Gong Chen , Pawlicki Alison A. , Ovchinnikova Olga S. , Munday Jeremy N. , Stranks Samuel D. , Leite Marina S. 
Published: July 2020

AbstractPerovskite semiconductors are an exciting class of materials due to their promising performance outputs in photovoltaic devices. To boost their efficiency further, researchers introduce additives during sample synthesis, such as KI. However, it is not well understood how KI changes the material and, often, leaves precipitants. To fully resolve the role of KI, multiple microscopy techniques are applied and the electrical and chemical behavior of a Reference (untreated) and a KI‐treated perovskite are compared. Upon correlation between electrical and chemical nanoimaging techniques, it is discovered that these local properties are linked to the macroscopic voltage enhancement of the KI‐treated perovskite. The heterogeneity revealed in both the local electrical and chemical responses indicates that the additive partially migrates to the surface, yet surprisingly does not deteriorate the performance locally, rather, the voltage response homogeneously increases. The research presented within provides a diagnostic methodology, which connects the nanoscale electrical and chemical properties of materials, relevant to other perovskites, including multication and Pb‐free alternatives.
Clinical Translation of Nanomedicine and Biomaterials for Cancer Immunotherapy: Progress and Perspectives
Authors: Shi Yang 
Published: July 2020

AbstractAdvances in immuno‐oncology have significantly improved cancer therapy outcomes. Unfortunately, potent responses to immunotherapy have only been achieved in subsets of patients. Nanomedicines and biomaterials have enormous potential for making immunotherapy work better in more patients, which has been suggested by a large number of preclinical studies. However, it remains unclear whether and how these materials will really benefit cancer patients treated by immunotherapy. Therefore, reviewing current clinical studies on nanomedicines and biomaterials in immuno‐oncology may provide valuable information for future translation research. In this work, the clinical landscape of cancer immunotherapy involving nanomedicines and biomaterials, mainly Abraxane, Doxil, messenger ribonucleic acid (mRNA) nanovaccines, and a biomaterial scaffold‐supported autologous vaccine, is reviewed. Clinical results demonstrate the high potential of nano/biomaterials in immunotherapy, achieved by rationalized utilization of their targeted delivery and reduced toxicities/side effects. Future clinical translation in this field will likely benefit from designing rational combinations of nanomedicines and biomaterials with the right immunotherapeutics applied in the right patients/tumors, and this should be achieved with the help of immune biomarker analysis. By rationally utilizing the unique features and advantages of nanomedicines and biomaterials, they will highly impact patient care in combination with immunotherapy.
MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy
Authors: Wei Yan , Song Sha , Duan Nianxiu , Wang Feng , Wang Yuxi , Yang Yiwei , Peng Chengyuan , Li Junjun , Nie Di , Zhang Xinxin , Guo Shiyan , Zhu Chunliu , Yu Miaorong , Gan Yong 
Published: July 2020

AbstractPromoting tumor angiogenesis effectively and specifically to resolve tumor‐associated hypoperfusion holds promise for improving pancreatic cancer therapy. Herein, a doxorubicin (DOX) loaded smart liposome, MC‐T‐DOX, is constructed, that carries appropriately low‐density cilengitide, an αvβ3 integrin‐specific Arg‐Gly‐Asp (RGD)‐mimetic cyclic peptide, via a membrane type 1‐matrix metalloproteinase (MT1‐MMP) cleavable peptide. After being administered systemically in a hypoperfused pancreatic cancer mouse model at a low dose of cilengitide, the proangiogenic activity of MC‐T‐DOX is specifically “turned on” in tumor vessels through cleavage by MT1‐MMP on tumor endothelial cells to release cilengitide. This locally released cilengitide increases tumor blood perfusion, thereby improving the accumulation and distribution of MC‐T‐DOX in the tumor site. The loaded‐DOX then displays enhanced penetration and increased cellular uptake upon heat‐triggered release from MC‐T‐DOX in the tumor interstitium, contributing to the improved tumor therapy efficacy. Therefore, the strategy of combining the modulation of tumor vascular promotion with smart nanodrug delivery represents a promising approach to improving drug delivery and therapeutic efficacy in a wide range of hypoperfused tumors.
“Necessary Compromises”: A Qualitative Exploration of the Influence of Burnout on Resident Education
Authors: Lu Dave W. , Germann Carl A. , Nelson Sara W. , Jauregui Joshua , Strout Tania D. 
Published: July 2020

AbstractObjectiveBurnout is prevalent among resident physicians and has a negative impact on their well‐being and effectiveness at work. How burnout shapes residents’ educational experiences, attitudes, habits, and practices is not well understood. There is also a lack of research regarding self‐identified mitigation strategies for residents. The authors qualitatively explored burnout’s role in the educational experiences of resident physicians.MethodsQualitative data were generated from a sample of 29 emergency medicine residents through four semistructured focus groups across four institutions in January and February 2019. The authors employed a constructivist approach to thematic analysis. Transcripts were coded and organized into major and minor themes.ResultsResidents reported that a misalignment of their individual versus institutional priorities and a lack of agency were significant contributors to their burnout. Residents described how burnout affected multiple aspects of their education, including their motivation and curiosity to learn, engagement in scholarly activity, and teaching of others. Residents identified several ways of building a sense of community that they explained was most useful in mitigating their experiences with burnout.ConclusionBurnout had a negative influence on many facets of residents’ educational experiences during training. Program directors and educators can take resident‐identified steps to moderate its detrimental role on trainee education.
Banding of phosphorus as an alternative to lime for wheat in acid soil
Authors: Cho Whoi , Brorsen B. Wade , Arnall D.B. 
Published: July 2020

AbstractSoil acidification limits wheat (Triticum aestivum L.) yields and continues to intensify due to N application and crop harvesting. Applying agricultural limestone (aglime) is the most common remedy for soil acidity but requires a substantial investment. The banding of phosphorus (Banding P) with wheat seed is an alternative temporary solution with lower cash cost than aglime application. However, P2O5 fertilizer costs have increased, and Banding P treatment cannot prevent soil pH reduction. This study compares the net present value (NPV) of aglime and Banding P treatments over varied planning horizons for wheat production in acidic soil updating the work of Kaitibie et al. (2002). For sensitivity analysis, two wheat yield goals, two wheat prices, and two aglime prices were considered. Partial budgeting is used based on estimates from past agronomic research. Banding P treatment was always preferred with a 1‐yr planning horizon and was never preferred with a planning horizon of more than 3 yr. Due to increased P2O5 fertilizer price since 2002, the planning horizons where Banding P treatment now has higher NPV than aglime are shorter than those found by Kaitibie et al.
Non‐Interpenetrated Single‐Crystal Covalent Organic Frameworks
Authors: Liang Lin , Qiu Yi , Wang Wei David , Han Jing , Luo Yi , Yu Wei , Yin Guan‐Lin , Wang Zhi‐Peng , Zhang Lei , Ni Jianwei , Niu Jing , Sun Junliang , Ma Tianqiong , Wang Wei 
Published: July 2020

AbstractGrowth of covalent organic frameworks (COFs) as single crystals is extremely challenging. Inaccessibility of open‐structured single‐crystal COFs prevents the exploration of structure‐oriented applications. Herein we report for the first time a non‐interpenetrated single‐crystal COF, LZU‐306, which possesses the open structure constructed exclusively via covalent assembly. With a high void volume of 80 %, LZU‐306 was applied to investigate the intrinsic dynamics of reticulated tetraphenylethylene (TPE) as the individual aggregation‐induced‐emission moiety. Solid‐state 2H NMR investigation has determined that the rotation of benzene rings in TPE, being the freest among the reported cases, is as fast as 1.0×104 Hz at 203 K to 1.5×107 Hz at 293 K. This research not only explores a new paradigm for single‐crystal growth of open frameworks, but also provides a unique matrix‐isolation platform to reticulate functional moieties into a well‐defined and isolated state.
Present‐Day DNA Contamination in Ancient DNA Datasets
Authors: Peyrégne Stéphane , Prüfer Kay 
Published: July 2020

AbstractPresent‐day contamination can lead to false conclusions in ancient DNA studies. A number of methods are available to estimate contamination, which use a variety of signals and are appropriate for different types of data. Here an overview of currently available methods highlighting their strengths and weaknesses is provided, and a classification based on the signals used to estimate contamination is proposed. This overview aims at enabling researchers to choose the most appropriate methods for their dataset. Based on this classification, potential avenues for the further development of methods are discussed.
Communication, collaboration and contagion: “Virtualisation” of anatomy during COVID‐19
Authors: Byrnes Kevin G. , Kiely Patrick A. , Dunne Colum P. , McDermott Kieran W. , Coffey John Calvin 
Published: July 2020

AbstractCOVID‐19 has generated a global need for technologies that enable communication, collaboration, education and scientific discourse whilst maintaining physical distance. University closures due to COVID‐19 and physical distancing measures disrupt academic activities that previously occurred face‐to‐face. Restrictions placed on universities due to COVID‐19 have precluded most conventional forms of education, assessment, research and scientific discourse. Anatomists now require valid, robust and easy‐to‐use communication tools to facilitate remote teaching, learning and research. Recent advances in communication, video conferencing and digital technologies may facilitate continuity of teaching and research activities. Examples include highly‐interactive video conferencing technology, collaborative tools, social media and networking platforms. In this narrative review, we examine the utility of these technologies in supporting effective communication and professional activities of anatomists during COVID‐19 and after.