bluuebunny/crossref_metadata_2025_split huggingface dataset:
The correlation between spinal and chest wall deformities and pulmonary function in Marfan syndrome
Authors: Otremski Hila , Widmann Roger F. , Di Maio Mary F. , Ovadia Dror 
Published: July 2020

Purpose Scoliosis, chest wall deformities and pulmonary involvement are common features of Marfan syndrome (MFS). We aimed to assess the impact of spinal and chest wall deformities on pulmonary function in paediatric MFS patients with a surgically managed spinal deformity. Methods In this multicentre retrospective study, spirometry, lung volumes and radiographic imaging were performed on 26 MFS patients between the ages of seven and 18 years who were undergoing planned spinal fusion surgery for spinal deformity. A correlation analysis assessed the relationship between radiographic measurements of spinal and chest wall deformities and predicted total lung capacity (TLC), forced vital capacity (FVC) and the ratio between forced expiratory volume in one second and FVC (FEV1/FVC). Results In total, 18 patients (70%) had impaired pulmonary function. Thoracic kyphosis (mean 19.3°; -32° to 54°) had a strong positive correlation with FEV1/FVC (r = 0.65; p < 0.001). Significant decrease in FEV1/FVC below 80% occurred at kyphosis under 15° (p = 0.004). Kyphosis had a moderate negative correlation with FVC (r = -0.43; p = 0.03). Chest wall deformity had a strong negative correlation with FEV1/FVC (r = -0.61; p = 0.001). The magnitude of the thoracic curve (mean 55.2°; 28° to 92°) had a significant moderate negative correlation with TLC (r = -0.45; p = 0.04). Conclusion In MFS, three factors correlate with decreased pulmonary function measures: hypokyphosis, increasing chest wall deformity and increasing coronal curve magnitude. Hypokyphosis and increased chest wall deformity correlated with diminished FEV1/FVC; increasing thoracic spinal curvature with diminished TLC. Further analysis with a larger cohort will help better define the relationship between these deformities and pulmonary function in this unique population. Level of Evidence IV
Single-shot common-path off-axis dual-wavelength digital holographic microscopy
Authors: Kumar Manoj , Quan Xiangyu , Awatsuji Yasuhiro , Tamada Yosuke , Matoba Osamu 
Published: July 2020

A single-shot common-path off-axis self-interference dual-wavelength
digital holographic microscopic (DHM) system based on a cube beam
splitter is demonstrated to expand the phase range in a stepped
microstructure and for simultaneous measurement of the refractive
index and physical thickness of a specimen. In the system, two laser
beams with wavelengths of 532 nm and 632.8 nm are used. These laser
beams are combined to transilluminate the object under study, then the
object beam is divided into two beams by using a beam splitter
oriented in such a way that both the beams propagate in almost the
same direction, with an appropriate lateral separation between them.
One of the object beams is spatially filtered at its Fourier plane,
using a pinhole to generate a reference spherical beam free from the
object information. The reference beam interferes with the object beam
to form a digital hologram at the faceplate of the image sensor. The
phase information is extracted from a single recorded digital hologram
using the phase aberration compensation method that is based on
principal component analysis (PCA). Owing to the common-path
configuration, the system shows high temporal phase stability and it
is less vibration-sensitive compared to counterparts such as a
Mach–Zehnder type DHM. The performance of the dual-wavelength DHM
system is verified in two different application fields by conducting
the experiments using microsphere beads and living plant cells.
High-efficiency edge-coupling based on lithium niobate on an insulator wire waveguide
Authors: Li Ying , Lan Tian , Li Jing , Wang Zhiyong 
Published: July 2020

Edge-coupling on single-crystal thin-film lithium niobate on insulator (LNOI) was systematically studied in this paper. An inverse taper-shaped spot-size converter (SSC) to convert the mode field from the laser chip to a nanoscale LNOI waveguide was adopted to improve the coupling efficiency. Structure of the edge coupler was fully investigated and optimized by using the eigenmode expansion method. The single-mode conditions of the LNOI waveguide for three common communication bands were taken into consideration. Further, the length and tip width of the inverse taper, the cross-section dimensions of SiON waveguide, and the sidewall angle were investigated with respect to coupling efficiency. As a result, the maximum coupling efficiency from an edge coupler to laser chip can reach 54%, 48%, and 58% at 1550, 1310, and 850 nm in Z-cut LNOI for quasi-TM mode, respectively. This proposed work gives a better understanding of the function of the edge coupler based on LNOI material and provides an appropriate method for the design of an edge coupler with high efficiency, which could benefit the further application of high-density monolithic integrated optical components.
INTERAÇÃO MEDICAMENTOSA EM PACIENTES IDOSOS COM DISLIPIDEMIAS EM UNIDADE BÁSICA DE SAÚDE DE SANTANA DO CARIRI, CE, BRASIL
Authors: Barros Lucilene Galdino de , Santos Felisberto Farias , Sousa Júnior Dárcio Luiz de , Marques Ana Emília Formiga 
Published: July 2020

Este estudo teve como objetivo realizar uma análise de possiveis interações medicamentosas baseadas em dados de prescrições médicas para pacientes idosos que fi zessem uso de medicamentos para dislipidemias em unidade básica de saúde na cidade de Santana do Cariri, CE. A coleta e análise dos dados ocorreu entre agosto e setembro de 2018 no município de Santana do Cariri, CE. Trata-se de um estudo descritivo, quantitativo, retrospectivo e transversal. Para a identificação das possíveis interações medicamentosas, foi utilizada a plataforma Micromedex®. Foram selecionados pacientes idosos portadores de alguma dislipidemia, com idade mínima de 60 e máxima de 89 anos. A amostra total foi 40 prescrições, onde a população foi de 103 receituários, em que 80% era do sexo feminino e 20% masculine. Foi identifi cado um total de 37 interações; dentre estas, sinvastatina é o que aparece com maior frequência interagindo com outros fármacos, dentre os quais, o mais frequente foi com o anlodipino. A interação desses dois fármacos provocam interação no paciente é considerada grave, pois o indivíduo corre o risco de apresentar miopatias e rabdomiólise. Diante desses resultados, é importante a implantação de um serviço de farmácia clínica, que possibilita identificar possíveis problemas relacionados a medicamentos e interações, melhorando a farmacoterapia e a qualidade de vida do paciente, benefi ciando com uma assistência eficiente para minimizar riscos à saúde.
Problematika Pembatalan 605 Sertifikat Tanah Dalam Kawasan Otorita Batam ( Studi Putusan Ptun Tanjung Pinang No : 15/G/2014/PTUN - TPI )
Authors: Adhim Nur , Silviana Ana , Govianda Cinthya 
Published: July 2020

Certificates of land rights provide legal certainty to the holders. However, it is possible to file a claim by the party who feels disadvantaged which can result in the cancellation of the certificate. The purpose of this writing is to find out and analyze the reasons for certificates issued by the Batam City Land Office were prosecuted and canceled by PTUN, legal certainty for holders of land certificates whose certificates were canceled, and follow-up from the Batam City Land Office for cancellation of the certificates with court decisions. The method of approach of this research is socio-legal, the subject is PTUN Decision Number: 15/G/2014/PTUN-TPI and the object is legal certainty for holders of land certificates whose certificate is canceled by the court decision. Methods of collecting data were with primary data and secondary data. The results of the research show that the land certificate issued by the Batam City Land Office was brought to the court and canceled due to the illegal transfer of rights to the land of the Himpunan Pengusaha Kecil Pribumi (HPKP) to the Koperasi Usaha Melayu Raya, there is no legal certainty for holders of land certificates whose certificate was canceled with the court decision, as well as the follow-up to the Batam City Land Office was to carry out a court decision if an application had been made by the party who won, namely HPKP.Keywords: Legal Certainty, Cancellation, Certificate Of Land Rights.ABSTRAKSertifikat hak atas tanah memberikan kepastian hukum kepada para pemegangnya. Namun, terbuka kemungkinan diajukan gugatan oleh pihak yang merasa dirugikan yang dapat berakibat pada pembatalan sertifikat. Penulisan ini bertujuan untuk mengetahui dan menganalisis alasan sertifikat yang dikeluarkan oleh Kantor Pertanahan Kota Batam diperkarakan dan dibatalkan oleh PTUN, kepastian hukum bagi pemegang sertifikat tanah yang sertifikatnya dibatalkan, dan tindak lanjut Kantor Pertanahan Kota Batam terhadap pembatalan sertifikat dengan putusan pengadilan. Metode Pendekatan penelitian ini adalah socio-legal, subyeknya Putusan PTUN Nomor: 15/G/2014/PTUN-TPI dan obyeknya kepastian hukum bagi para pemegang sertifikat tanah yang sertifikatnya dibatalkan oleh putusan pengadilan. Metode pengumpulan data dengan data primer dan data sekunder. Hasil penelitian menujukkan alasan sertifikat tanah yang dikeluarkan oleh Kantor Pertanahan Kota Batam diperkarakan dan dibatalkan oleh PTUN adalah karena terjadi peralihan hak yang tidak sah atas lahan Himpunan Pengusaha Kecil Pribumi (HPKP) kepada Koperasi Serba Usaha Melayu Raya, tidak ada kepastian hukum bagi pemegang sertifikat tanah yang sertifikatnya dibatalkan dengan putusan pengadilan, serta tindak lanjut Kantor Pertanahan Kota Batam adalah melaksanakan putusan pengadilan bila telah dilakukan permohonan oleh pihak yang dimenangkan yaitu HPKP. Kata Kunci: Kepastian Hukum, Pembatalan, Sertifikat Hak Atas Tanah.
Paradigm Of Judicial Verdict
Authors: Soemarmi Amiek , Indarti Erlyn , Pujiyono Pujiyono 
Published: July 2020

A judge holds a paradigm that greatly influences the way in which reality is perceived. Grasping the meaning of reality will create a relationship between the judge itself, a paradigm follower, with a comprehended reality in which it will create a methodology for the solving the problem of the reality. Unconsciously, the paradigm will affect a judge in applying discretion. The discretion applied by one judge to another will be different. The difference is based on the diversity of its paradigm that will lead to disparity in the judicial verdict. The disparity in judicial verdicts occurs because of the paradigm of a judge embedded in himself. The paradigm of a judge will influence the extent to which discretionary constraints are applied. The diversity of paradigms adopted by judges will make a difference regarding to the limitation in applying discretion resulting the disparities in judicial verdicts. This study uses paradigm study in a qualitative research as the initial determinant where the dynamic variable is not always static. Construtive paradigm will guide the writer in doing the translation of data obtained through interview and other observation methods. ABSTRAKSeorang Hakim menganut paradigma yang sangat mempengaruhi terhadap cara memandang realitas, setelah menangkap makna dari realitas maka akan tercipta hubungan antara hakim itu sendiri selaku penganut paradigma tertentu dengan realitas yang dipahami, dimana keterkaitan itu akan menciptakan metodologi untuk menyelesaukan masalah-masalah terhadap realitas tersebut. Tanpa disadari paradigma tersebut akan mempengaruhi seorang hakim dalam menerapkan diskresi. Diskresi yang diterapkan seorang hakim yang satu dengan yang lainakan berbeda. Perbedaan tersebut dilandasi atas keberagaman paradigma yang dianutnya, perbedaan paradigma tersebut akan terjadi disparitas dalam putusan hakim. Disparitas putusan hakim terjadi karena paradigma seorang hakim yang tertanam pada dirinya sendiri. Paradigma seorang hakim akan mempengaruhi sejauh mana batasan diskresi yang diterapkan, dengan keberagaman paradigma yang dianut hakim akan menimbuklkan perbedaan mengenai batasan penerapan diskresi sehingga menghasilkan disparitas dalam putusan hakim. Penelitian ini menggunakan kajian paradigma dengan menggunakan penelitian kualitatif sebagai penentu awal dimana variabel bersifat dinamis yang tidak selamanya statis. Paradigmna konstruktivisme akan memandu penulis dalam melakukan penerjemahan data yang diperoleh melalui metode wawancara dan pengamatan lainnya.Kata Kunci: paradigma, hakim, putusan hakim.
Implikasi Hukum Penggunaan Surat Kuasa Membebankan Hak Tanggungan Sebagai Jaminan Dalam Perjanjian Kredit Pemilikan Rumah
Authors: Badriyah Siti Malikhatun , Suharto R. , Kashadi Kashadi 
Published: July 2020

In the agreement a strong guarantee is needed to provide legal protection for the parties. One of them is Encumbrance Right. Encumbrance Right occur after registration of Underwriting Rights at the Land Office. But in practice, often the Encumbrance Right only reaches the making of Power Of Attorney To Establish Encumbrance Right (SKMHT). This study aims to find evidence and analyze the use of SKMHT in the Housing Ownership Credit (KPR) agreement and its legal consequences if the debtor defaults. The research method used is qualitative with a socio legal approach. The results of the study indicate that in the KPR agreement many liability rights are imposed by using SKMHT without being followed by the making of the Deed of Giving Encumbrance Rights and the Registration of Encumbrance Rights. As a result, Encumbrance Rights do not occur, so that if the debtor defaults on the creditor does not have the right of execution as the holder of the Encumbrance Rights as determined in the Encumbrance Rights Act. ABSTRAK Dalam perjanjian dibutuhkan jaminan yang kuat untuk memberikan perlindungan hukum bagi para pihak. Salah satunya adalah Hak Tanggungan. Hak Tanggungan terjadi setelah pendaftaran Hak Tanggungan di Kantor Pertanahan. Namun dalam praktik seringkali Hak Tanggungan hanya sampai pada pembuatan Surat Kuasa Membebankan Hak Tanggungan (SKMHT). Penelitian ini bertujuan untuk mencari bukti-bukti dan menganalisis penggunaan SKMHT dalam perjanjian Kredit Pemilikan Rumah (KPR) serta akibat hukumnya jika debitor wanprestasi. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan socio legal. Hasil penelitian menunjukkan bahwa dalam perjanjian KPR banyak dilakukan pembebanan Hak Tanggungan dengan menggunakan SKMHT tanpa diikuti dengan pembuatan Akta Pemberian Hak Tanggungan dan Pendaftaran Hak Tanggungan. Akibatnya Hak Tanggungan tidak terjadi, sehingga jika debitor wanprestasi kreditor tidak memiliki hak eksekusi sebagai Penerima Hak Tanggungan sebagaimana ditentukan dalam Undang-undang Hak Tanggungan.Kata Kunci: hak tanggungan, kredit, surat kuasa, hak tanggungan, wanprestasi.
Hambatan Implementasi Pencegahan Tindak Pidana Korupsi pada Pelaksanaan Program Dana Desa di Kabupaten Gresik
Authors: Rusdiana Emmilia , Astuti Pudji , Hikmah Nurul , Ali Ahmad Gelar 
Published: July 2020

Tindak pidana korupsi adalah extra ordinary crime, yakni tindak pidana yang memerlukan keterlibatan banyak pihak, cara yang tidak biasa dan melibatkan komitmen dari masyarakat. Salah satu upaya pencegahan tindak pidana korupsi adalah melalui pemberian contoh-contoh berbagai usaha mencegah dan menentang korupsi serta strategi dan rencana aksi pemberantasan korupsi dan integritas dan nilai-nilai antikorupsi. Sehubungan dengan pengawasan pada penggunaan anggaran negara melalui dana desa, maka tujuan penelitian ini adalah menganalisis hambatan dalam penerapan pencegahan korupsi pada penggunaan dana desa. Metode penelitian yang digunakan adalah penelitian eksploratif dengan analisis data secara deskriptif kualitatif. Hasil penelitian menunjukkan bahwa perwujudan pencegahan korupsi pada penggunaan dana desa pada Dinas Pemerintahan Masyarakat dan Desa {PMD)dan Pemerintah Desa Suci, Desa Yosowilangun dan Desa Giri pada Pencegahan korupsi adalah pertama, pemahaman yang rendah mengenai gerakan anti korupsi berupa pemenuhan unsur monitoring dan evaluasi, pemenuhan dokumen saat perencanaan dan pelaksanaan dan administrasi kegiatan. Kedua, bentuk pencegahan korupsi adalah dengan munculnya rasa ketakutan untuk melakukan pelanggaran pada peraturan pelaksanaan penggunaan dana desa tersebut. Ketiga, pembahasan mengenai Pencegahan korupsi seakan-akan merupakan kajian yang baru dan tabu untuk diadakan pembahasan lebih lanjut.
ÜBER FREMDSPRACHENLERNEN DISKUTIEREN – MIT HILFE DIALOGISCHER LERNTAGEBÜCHER
Authors: Nerlicki Krzysztof 
Published: July 2020

Learning journals are widely used in second/foreign language research. They are not only tools to gather data but also contribute to optimization of the learning process and help students become more autonomous.
The discussion presented here focuses on dialogue journals, which are used for ongoing written interaction between the teacher and learners. The paper provides a terminological basis, gives examples of topics and describes the characteristics of the teacher-student dialogue management. The advantages and disadvantages of dialogue journals are discussed from the didactic perspective. The last part of the paper concerns empirical problems to be taken into account when learning journals are introduced and used.
Fe3O4@urea/HITh-SO3H as an efficient and reusable catalyst for the solvent-free synthesis of 7-aryl-8H-benzo[h]indeno[1,2-b]quinoline-8-one and indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine derivatives
Authors: Jiang Shenghao , Shen Macheng , Sheykhahmad Fatima Rashid 
Published: July 2020

AbstractIn this study, Fe3O4@urea/HITh-SO3H MNPs as a new, efficient, and recyclable solid acid magnetic nanocatalyst was synthesized and characterized using various methods including Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, energy-dispersive X-ray spectroscopy, and X-ray powder diffraction. After the characterization of this new magnetic nanocatalyst, it was efficiently utilized for the promotion of the one-pot synthesis of 7-aryl-8H-benzo[h]indeno[1,2-b]quinoline-8-one and indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine derivatives via three-component reaction of the 1,3-indanedione, aldehyde, and 1-naphthylamine/1,3-dimethyl-6-aminouracil under solvent-free conditions at 80°C. The procedure gave the desired heterocyclic structures in high-to-excellent yields and short reaction times. Also because of the magnetic nature of the nanocatalyst, it can be separated with an external magnetic field and reused at least six runs without any considerable decrease in the catalytic behavior.
Effect of natural boron mineral use on the essential oil ratio and components of Musk Sage (Salvia sclarea L.)
Authors: Karayel Hasan Basri 
Published: July 2020

AbstractThis study was aimed to determine the effect of different boron doses (boron free, pure boron with 8 liters per decare and in 1/8 ratio diluted boron) on the rate and quality of volatile oil in musk grown in Kütahya-Gediz conditions. Essential oil from Musk Sage was obtained by hydrodistillation method (GC-MS/FID). In the analysis carried out in 2017, the rate of essential oil was found to be 0.11% in the plant grown without boron, while it was 0.44% in the plant grown with pure boron. However, this rate was found as 0.23% in the 1/8 boron ratio application. The main components of volatile oil were found as follows: for the boron-free application—spathulenol 23.75%, caryophyllene oxide 19.41%, linalool 10.10%, and sclareoloxide 9.92%; for the pure dose application—spathulenol 26.67%, sclareoloxide 18.81%, and caryophyllene oxide 16.13%; for in 1/8 ratio diluted boron dose application—spathulenol 24.82%, sclareoloxide 16.68%, and caryophyllene oxide 14.86%. It has been observed that pure boron dose has a positive effect on the essential oil ratio and components of Musk Sage.
Structural cytotoxicity relationship of 2-phenoxy(thiomethyl)pyridotriazolopyrimidines: Quantum chemical calculations and statistical analysis
Authors: Abuelizz Hatem A. , Anouar El Hassane , Al-Shakliah Nasser S. , Marzouk Mohamed , Al-Salahi Rashad 
Published: July 2020

AbstractPreviously, a series of pyridotriazolopyrimidines (1–6) were synthesized and fully described. The target compounds (1–6) were evaluated for their cytotoxicity against MCF-7, HepG2, WRL 68, and A549 (breast adenocarcinoma, hepatocellular carcinoma, embryonic liver, and pulmonary adenocarcinoma, respectively) cell lines using MTT assay. The tested compounds demonstrated cytotoxicity, but no significant activity. To elucidate the structure–cytotoxicity relation of the prepared pyridotriazolopyrimidines, several chemical descriptors were determined, including electronic, steric, and hydrophobic descriptors. These chemical descriptors were calculated in the polarizable continuum model (water as solvent) using density functional theory calculations at B3LYP/6-31+G(d,p). By employing simple linear regression (SLR) and multiple linear regression (MLR) analyses, the impact of the selected descriptors was assessed statistically. The obtained results clearly reveal that the cytotoxicity of pyridotriazolopyrimidines depends on their (i) basic skeleton and (ii) the type of the tested cell. Interestingly, SLR and MLR analyses show that the impact of the selected descriptors is strongly related to the tested cells and basic skeleton of the tested compounds. For instance, the cytotoxicity of subclasses 2a and 2c–2f against A459 shows strong correlation with ionization potential, hardness (η), and hydrophobicity (log P) with a correlation coefficient of 99.86% and a standard deviation of 0.53.
Synthesis, characterization, and pharmacological evaluation of thiourea derivatives
Authors: Naz Sumaira , Zahoor Muhammad , Umar Muhammad Naveed , Alghamdi Saad , Sahibzada Muhammad Umar Khayam , UlBari Wasim 
Published: July 2020

AbstractThioureas and their derivatives are organosulfur compounds having applications in numerous fields such as organic synthesis and pharmaceutical industries. Symmetric thiourea derivatives were synthesized by the reaction of various anilines with CS2. The synthesized compounds were characterized using the UV-visible and nuclear magnetic resonance (NMR) spectroscopic techniques. The compounds were screened forin vitroinhibition of α-amylase, α-glucosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) enzymes and for their antibacterial and antioxidant potentials. These compounds were fed to Swiss male albino mice to evaluate their toxicological effects and potential to inhibit glucose-6-phosphatase (G6Pase) inhibition. The antibacterial studies revealed that compound4was more active against the selected bacterial strains. Compound1was more active against 2,2-diphenyl-1-picrylhydrazyl and 2,2’-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radicals, AChE, BuChE, and α-glucosidase. Compound2was more potent against α-amylase and G6Pase. Toxicity studies showed that compound4is safe as it exerted no toxic effect on any of the hematological and biochemical parameters or on liver histology of the experimental animals at any studied dose rate. The synthesized compounds showed promising antibacterial and antioxidant potential and were very active (bothin vitroandin vivo) against G6Pase and moderately active against the other selected enzymes used in this study.