bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origin of noble-metal nuggets in sulfide-saturated arc magmas: A case study of olivine-hosted sulfide melt inclusions from the Tolbachik volcano (Kamchatka, Russia)
Authors: Kamenetsky Vadim S. , Zelenski Michael 
Published: April 2020

AbstractMinerals that contain platinum-group elements (PGEs) and occur in some magmatic Cu-Ni sulfide deposits have been ascribed to crystallization from an originally PGE-rich sulfide liquid. The occurrence of PGE-bearing minerals (PGMs) in some sulfide-undersaturated primitive melts has been envisaged and recently reported, whereas direct crystallization of PGMs in sulfide-saturated silicate magmas is seemingly hindered by strong partitioning of PGE into immiscible sulfide melts. In this study, we discovered abundant nanoparticles containing noble metals in association with sulfide melt inclusions entrapped inside primitive olivine phenocrysts (Fo85–92) from the recent basaltic magma of the Tolbachik volcano (Kamchatka arc, Russia). These nuggets occur in swarms on the surface of the sulfide globules and are represented by native metals, sulfides, and alloys of Pd, Pt, Au, Pb, and Bi. The nuggets on different globules can be either Pd- or Pt-rich nuggets, and the compositions are highly variable, even among adjacent nuggets. We argue that the diffusive supply of Pd from the external nuggets can be responsible for significant uptake of Pd (up to 2 wt%) in the sulfide melt. We consider direct crystallization of PGMs in a primitive basaltic melt undergoing sulfide unmixing, and possibly sulfide breakdown due to oxidation, as another mechanism additional to their “classic” origin from the PGE-rich sulfide melt in response to solidification.
Delayed maximum and recession of an East Antarctic outlet glacier
Authors: King Courtney , Hall Brenda , Hillebrand Trevor , Stone John 
Published: April 2020

Abstract
During the last glaciation, East Antarctic outlet glaciers contributed to a grounded ice sheet in the Ross Embayment. The timing of maximum ice extent, as well as of subsequent deglaciation of these outlets, has implications for the behavior of the Antarctic Ice Sheet (AIS) and its impact on global sea level. We present 45 radiocarbon ages of lacustrine cyanobacteria from the Lake Wellman region alongside Hatherton Glacier, which are the first terrestrial data to both record advance of an Antarctic glacier to its maximum position as well as document a high-resolution chronology of subsequent retreat. Seventeen new exposure ages are widely scattered, but the youngest four are in broad agreement with the radiocarbon data. Hatherton Glacier slowly thickened from 13,000 to 9500 yr B.P. and then thinned steadily until at least ca. 2800 yr B.P. Our work affords evidence of both a delayed maximum and recession of an East Antarctic outlet glacier compared to the global Last Glacial Maximum (LGM) and supports growing evidence of a time-transgressive local LGM within the Ross Sea sector of the ice sheet. Both observations are consistent with the idea that the timing of outlet glacier expansion and timing of recession are controlled by the balance between dynamic thinning from ocean forcing and increased accumulation due to atmospheric warming.
Usual care and a self-management support programme versus usual care and a relaxation programme for people living with chronic headache disorders: a randomised controlled trial protocol (CHESS)
Authors: Patel Shilpa , Achana Felix , Carnes Dawn , Eldridge Sandra , Ellard David R , Griffiths Frances , Haywood Kirstie , Hee Siew Wan , Mistry Dipesh , Mistry Hema , Nichols Vivien P , Petrou Stavros , Pincus Tamar , Potter Rachel , Sandhu Harbinder Kaur , Stewart Kimberley , Taylor Stephanie , Underwood Martin , Matharu Manjit 
Published: April 2020

IntroductionChronic headaches are poorly diagnosed and managed and can be exacerbated by medication overuse. There is insufficient evidence on the non-pharmacological approaches to helping people living with chronic headaches.Methods and analysisChronic Headache Education and Self-management Study is a pragmatic randomised controlled trial to test the effectiveness and cost-effectiveness of a self-management education support programme on top of usual care for patients with chronic headaches against a control of usual care and relaxation. The intervention is a 2-day group course based on education, personal reflection and a cognitive behavioural approach, plus a nurse-led one-to-one consultation and follow-up over 8 weeks. We aim to recruit 689 participants (356 to the intervention arm and 333 to the control) from primary care and self-referral in London and the Midlands. The trial is powered to show a difference of 2.0 points on the Headache Impact Test, a patient-reported outcome measure at 12 months post randomisation. Secondary outcomes include health related quality of life, self-efficacy, social activation and engagement, anxiety and depression and healthcare utilisation. Outcomes are being measured at 4, 8 and 12 months. Cost-effectiveness will be expressed in terms of incremental cost per quality-adjusted life year gained.Ethics and disseminationThis trial will provide data on effectiveness and cost-effectiveness of a self-management support programme for chronic headaches. The results will inform commissioning of services and clinical practice. North West – Greater Manchester East Research Ethics Committee have approved the trial. The current protocol version is 3.6 date 7 March 2019.Trial registration numberISRCTN79708100.
Novel compound LL-a produces long and nociceptive-selective regional anesthesia via TRPV1 channels in rodents sciatic nerve block model
Authors: Zhou Cheng , Tang Lei , Yin Qinqin , Yang Linghui , Gong Deying , Kang Yi , Cao Hangxue , Fan Jing , Zhang Yujun , Qian Duo , Zhang Qianqian , Ke Bowen , Liu Jin , Zhang Wensheng , Yang Jun 
Published: April 2020

Background and objectiveLong-acting nociceptive-selective regional anesthesia has remained an elusive clinical goal. We aspired to identify a novel compound that would produce nociceptive-selective regional anesthesia through the transient receptor potential vanilloid 1 (TRPV1) channels.MethodsWe designed and synthesized a novel compound (LL-a) that penetrates the cell membrane through TRPV1 channels and binds to voltage-gated sodium channels. The regional anesthetic effect of LL-a was evaluated in a rodent sciatic nerve block model. Electrophysiological recording was applied to test the inhibition of LL-a on voltage-gated sodium channel currents.ResultsLL-a inhibited sodium channel currents on the dorsal root ganglion neurons of mice and this action was diminished by TRPV1 channel knockout. In a sciatic nerve block model of a rat, 0.2% and 0.4% (w/v) LL-a produced selective sensory block with median (IQR) durations of 42.0 (24.0, 48.0) and 72.0 (69.0, 78.0) hours, respectively. No motor block was found for 0.2% LL-a. 0.4% LL-a produced a motor block with a median (IQR) duration of 3.0 (0.0, 6.0) hours. This selective sensory block was not observed on TRPV1 knockout mice. As a positive control, 0.5% and 0.75% levobupivacaine produced a non-selective sciatic nerve block with median (IQR) durations of 2.8 (2.6, 2.8) and 3.8 (3.8, 4.8) hours, respectively. No systemic or local irritation was observed during injection of LL-a and sensory and motor function completely recovered for all the animals.ConclusionsLL-a is a potential novel local anesthetic for long-lasting nociceptive-selective analgesia.
Stochastic inflaton wave equation from an expanding environment
Authors: Haba Z. 
Published: April 2020

AbstractWe discuss the inflaton $$\phi $$ϕ in an environment of scalar fields $$\chi _{n}$$χn on flat and curved manifolds. We average over the environmental fields $$\chi _{n}$$χn. We study a contribution of superhorizon $$k\ll aH$$k≪aH as well as subhorizon $$k \gg aH$$k≫aH modes $$\chi _{n}(\mathbf{k})$$χn(k). As a result we obtain a stochastic wave equation with a friction and noise. We show that in the subhorizon regime in field theory a finite number of fields is sufficient to produce a friction and diffusion owing to the infinite number of degrees of freedom corresponding to different $$\mathbf{k}$$k in $$\chi _{n}(\mathbf{k})$$χn(k). We investigate the slow roll and the Markovian approximations to the stochastic wave equation. A determination of the metric from the stochastic Einstein–Klein–Gordon equations is briefly discussed.
Interior solutions of relativistic stars in the scale-dependent scenario
Authors: Panotopoulos Grigoris , Rincón Ángel , Lopes Ilídio 
Published: April 2020

AbstractWe study relativistic stars in the scale-dependent scenario, which is one of the approaches to quantum gravity, and where Newton’s constant is promoted to a scale-dependent quantity. First, the generalized structure equations are derived here for the first time. Then they are integrated numerically assuming a linear equation-of-state in the simplest MIT bag model for quark matter. We compute the radius, the mass and the compactness of strange quarks stars, and we show that the energy conditions are fulfilled.
The Hi's and Lo's of Cytarabine in Acute Myeloid Leukemia
Authors: Watts Justin M. , Bradley Terrence 
Published: April 2020

Abstract
Cytarabine is the backbone of AML therapy, but the dose used during induction has remained controversial. Using an intermediate dose of cytarabine, compared with conventional dose, was shown to improve disease-free and overall survival in adult patients in China up to age 55, particularly in patients with intermediate cytogenetic risk.
See related article by Wei et al., p. 3154
Etiologic Workup in Cases of Cryptogenic Stroke
Authors: McMahon Naoimh E. , Bangee Munirah , Benedetto Valerio , Bray Emma P. , Georgiou Rachel F. , Gibson Josephine M.E. , Lane Deirdre A. , Al-Khalidi A. Hakam , Chatterjee Kausik , Chauhan Umesh , Clegg Andrew J. , Lightbody C. Elizabeth , Lip Gregory Y.H. , Sekhar Alakendu , Watkins Caroline L. 
Published: April 2020

Background and Purpose—
Identifying the etiology of acute ischemic stroke is essential for effective secondary prevention. However, in at least one third of ischemic strokes, existing investigative protocols fail to determine the underlying cause. Establishing etiology is complicated by variation in clinical practice, often reflecting preferences of treating clinicians and variable availability of investigative techniques. In this review, we systematically assess the extent to which there exists consensus, disagreement, and gaps in clinical practice recommendations on etiologic workup in acute ischemic stroke.

Methods—
We identified clinical practice guidelines/consensus statements through searches of 4 electronic databases and hand-searching of websites/reference lists. Two reviewers independently assessed reports for eligibility. We extracted data on report characteristics and recommendations relating to etiologic workup in acute ischemic stroke and in cases of cryptogenic stroke. Quality was assessed using the AGREE II tool (Appraisal of Guidelines for Research & Evaluation). Recommendations were synthesized according to a published algorithm for diagnostic evaluation in cryptogenic stroke.

Results—
We retrieved 16 clinical practice guidelines and 7 consensus statements addressing acute stroke management (n=12), atrial fibrillation (n=5), imaging (n=5), and secondary prevention (n=1). Five reports were of overall high quality. For all patients, guidelines recommended routine brain imaging, noninvasive vascular imaging, a 12-lead ECG, and routine blood tests/laboratory investigations. Additionally, ECG monitoring (>24 hours) was recommended for patients with suspected embolic stroke and echocardiography for patients with suspected cardiac source. Three reports recommended investigations for rarer causes of stroke. None of the reports provided guidance on the extent of investigation needed before classifying a stroke as cryptogenic.

Conclusions—
While consensus exists surrounding standard etiologic workup, there is little agreement on more advanced investigations for rarer causes of acute ischemic stroke. This gap in guidance, and in the underpinning evidence, demonstrates missed opportunities to better understand and protect against ongoing stroke risk.

Registration—

URL:
https://www.crd.york.ac.uk/PROSPERO/
; Unique identifier: CRD42019127822.
High-Sensitivity Cardiac Troponin T and Cognitive Function in Patients With Ischemic Stroke
Authors: Broersen Leonie H.A. , Siegerink Bob , Sperber Pia S. , von Rennenberg Regina , Piper Sophie K. , Nolte Christian H. , Heuschmann Peter U. , Endres Matthias , Scheitz Jan F. , Liman Thomas G. 
Published: April 2020

Background and Purpose—
Our study aim was to assess whether high-sensitivity cardiac troponin T (hs-cTnT), a specific biomarker for myocardial injury, is associated with cognitive function in patients after mild-to-moderate first-ever ischemic stroke.

Methods—
We used data from PROSCIS-B (Prospective Cohort With Incident Stroke Berlin). Cognitive function was assessed by Mini-Mental-State-Examination at baseline, and Telephone Interview for Cognitive Status–modified after 1 to 3 years of follow-up. Patients were categorized according to hs-cTnT quartiles. We performed generalized linear regression to calculate risk ratios of cognitive impairment (Mini-Mental-State-Examination <27; Telephone Interview for Cognitive Status–modified <32). Association of hs-cTnT with cognitive function over time was estimated using a linear mixed model.

Results—
We included 555 patients (mean age, 67 years, 62% male, median National Institutes of Health Stroke Scale 2 [interquartile range, 1–5], hs-cTnT above upper reference limit 40%, baseline cognitive impairment 28%). Baseline Mini-Mental-State-Examination score and rate of cognitive impairment were lower in patients in the highest versus lowest hs-cTnT quartile (median Mini-Mental-State-Examination 27 versus 29, and 15.3% versus 43.0%, adjusted risk ratio, 1.76 [95% CI, 1.07–2.90], respectively). If anything, cognition seemed to improve in all groups, yet Telephone Interview for Cognitive Status–modified scores were consistently lower in patients within the highest versus lowest hs-cTnT quartile (adjusted β, −1.33 [95% CI, −2.65 to −0.02]), without difference in the rate of change over time.

Conclusions—
In patients with mild-to-moderate first-ever ischemic stroke without dementia, higher hs-cTnT was associated with higher prevalence of cognitive impairment at baseline and lower Telephone Interview for Cognitive Status–modified during 3-year follow-up.

Registration—

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01363856.
Prx2 (Peroxiredoxin 2) as a Cause of Hydrocephalus After Intraventricular Hemorrhage
Authors: Tan Xiaoxiao , Chen Jingyin , Keep Richard F. , Xi Guohua , Hua Ya 
Published: April 2020

Background and Purpose—
Our recent study demonstrated that release of Prx2 (peroxiredoxin 2) from red blood cells (RBCs) is involved in the inflammatory response and brain injury after intracerebral hemorrhage. The current study investigated the role of extracellular Prx2 in hydrocephalus development after experimental intraventricular hemorrhage.

Methods—
There were 4 parts in this study. First, Sprague-Dawley rats received an intraventricular injection of lysed RBC or saline and were euthanized at 1 hour for Prx2 measurements. Second, rats received an intraventricular injection of Prx2, deactivated Prx2, or saline. Third, lysed RBC was coinjected with conoidin A, a Prx2 inhibitor, or vehicle. Fourth, rats received Prx2 injection and were treated with minocycline or saline (i.p.). The effects of Prx2 and the inhibitors were examined using magnetic resonance imaging assessing ventriculomegaly, histology assessing ventricular wall damage, and immunohistochemistry to assess inflammation, particularly at the choroid plexus.

Results—
Intraventricular injection of lysed RBC resulted in increased brain Prx2 and hydrocephalus. Intraventricular injection of Prx2 alone caused hydrocephalus, ventricular wall damage, activation of choroid plexus epiplexus cells (macrophages), and an accumulation of neutrophils. Conoidin A attenuated lysed RBC-induced injury. Systemic minocycline treatment reduced the epiplexus cell activation and hydrocephalus induced by Prx2.

Conclusions—
Prx2 contributed to the intraventricular hemorrhage-induced hydrocephalus, probably by inducing inflammatory responses in choroid plexus and ventricular wall damage.
Impacts of Storm Track Variations on Wintertime Extreme Precipitation and Moisture Budgets over the Ohio Valley and Northwestern United States
Authors: Ma Chen-Geng , Chang Edmund K. M. , Wong Sun , Zhang Rui , Zhang Minghua , Del Genio Anthony 
Published: April 2020

AbstractPrevious studies have shown that variations in extratropical cyclone activity significantly affect the frequency of extreme precipitation events over the Ohio Valley and northwestern United States. In this study, we examine the similarities and differences between the dynamics governing these events in these two regions. In the Ohio Valley, extreme precipitation events are associated with midlatitude synoptic-scale convergence northeast of cyclones and a southwestward oriented ridge near the Atlantic coast that drives strong water vapor transport from the Gulf of Mexico into the Ohio Valley. In the northwestern United States, extreme precipitation events are associated with a cyclonic and anticyclonic circulation pair aligned northwest to southeast, which together drive a long and strong moisture transport corridor from the lower latitude of the central Pacific Ocean toward the northwestern United States. Moisture budget analysis shows that moisture convergence due to dynamical convergence dominates in the Ohio Valley, whereas moisture advection dominates over the Pacific Northwest. Differences between the cases in the same region are examined by an empirical orthogonal function (EOF) analysis conducted on the vertically integrated moisture flux. Different EOFs highlight shifts in spatial location, orientation, and intensity of the moisture flux but demonstrate consistent roles of dynamics in the two regions. Composites based on these EOFs highlight the range of likely synoptic scenarios that can give rise to precipitation extremes over these two regions.
Severe Weather Forecasts and Public Perceptions: An Analysis of the 2011 Super Outbreak in Tuscaloosa, Alabama
Authors: Sanders Shadya , Adams Terri , Joseph Everette 
Published: April 2020

AbstractThis paper uses the “Super Outbreak” of 2011 as a case study to examine the potential gaps between the dissemination of severe weather warnings and the public’s behavioral response to this information. This study focuses on a single tornado track that passed through Tuscaloosa, Alabama. The tornado caused massive damage and destruction and led to a total of 62 fatalities. The threat of severe storms was known days in advance, and forecasts were disseminated to the public. Questions were raised about the forecasts, warning lead times, and the perception of the warnings among residents. This paper examines the potential gaps that exist between the dissemination of tornadic warning information and citizen response. The analysis of data collected through a mixed-method approach suggests that, regardless of weather forecast accuracy, a significant chasm exists between the dissemination of warnings and the personalizing of risks, which results in limited use of protective measures in the face of severe weather threats.
Titanium dioxide nanoparticles induce endoplasmic reticulum stress-mediated apoptotic cell death in liver cancer cells
Authors: Li Zhiwang , He Jingliang , Li Bowei , Zhang Jinqian , He Ke , Duan Xiaopeng , Huang Rui , Wu Zuguang , Xiang Guoan 
Published: April 2020

Objective Titanium oxide (TiO2) acts as a photosensitizer in photodynamic therapy by mediating reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress. This study aimed to investigate the effect of TiO2 on ER stress in liver cancer cells. Methods Normal human liver and human hepatocarcinoma cell lines were incubated with various concentrations of TiO2 nanotubes for 48 hours. Cell growth, apoptosis, cell cycle, and cellular ROS were detected. Expression levels of ER stress sensors (PERK and ATF6) and Bax were evaluated by western blot. The effect of TiO2 on liver cancer growth was also investigated in mice in vivo. Results TiO2 inhibited cell growth, increased apoptosis and cellular ROS levels, and arrested the cell cycle in G1 stage in liver cancer cells. TiO2 also increased PERK, ATF6, and Bax expression levels in liver cancer cells in dose-dependent manners. TiO2 had no significant effect on cell growth, apoptosis, ROS level, cell cycle distribution, or PERK, ATF6, or Bax expression in normal liver cells. TiO2 administration reduced tumor volume and increased PERK, Bax, and ATF6 expression levels in tumor tissues in vivo. Conclusions TiO2 nanoparticles increased ROS-induced ER stress and activated the PERK/ATF6/Bax axis in liver cancer cells in vitro and in vivo.
A retrospective analysis of factors affecting surgical site infection in orthopaedic patients
Authors: Yang Jun , Zhang Xiangmin , Liang Wangbo 
Published: April 2020

Objective To investigate the factors affecting surgical site infections (SSI) in patients undergoing orthopaedic surgery. Methods The electronic medical records of patients undergoing orthopaedic surgery between September 2010 and July 2018 were retrospectively retrieved and reviewed. Logistic regression analyses were used to analyse the correlation between surgery-related variables and SSI. The odds ratio (OR) and 95% confidence interval (CI) were estimated for the risk factors. Results Clinical data from 25 954 patients were reviewed and 804 (3.1%) were found to have become infected at the surgical site. Older age (≥60 years) was a risk factor (OR 2.218) and younger age (<18 years) was a protective factor (OR 0.258). Diabetes mellitus (OR 6.560) and hypertension (OR 3.991) were independent risk factors. Compared with type II incisions, type I incisions had a lower risk for SSI (OR 0.031), while type III incisions had a greater risk of SSI (OR 2.599). Compared with upper limbs and hands, the feet had a lower risk of infection, while surgery performed at the spine and joints did not increase the risk as compared with foot surgery. Conclusion Older age, hypertension, diabetes mellitus and type III incisions were risk factors for SSI following orthopaedic surgery.