bluuebunny/crossref_metadata_2025_split huggingface dataset:
The orbitopterygoid corridor as a deep keyhole for endoscopic access to the paranasal sinuses and clivus
Authors: Oyama Kenichi , Watanabe Kentaro , Hanakita Shunya , Champagne Pierre-Olivier , Passeri Thibault , Voormolen Eduard H. , Bernat Anne Laure , Penet Nicolas , Fukushima Takanori , Froelich Sébastien 
Published: June 2020

OBJECTIVE
The anteromedial triangle (AMT) is the triangle formed by the ophthalmic (V1) and maxillary (V2) nerves. Opening of this bony space offers a limited access to the sphenoid sinus (SphS). This study aims to demonstrate the utility of the orbitopterygopalatine corridor (OPC), obtained by enlarging the AMT and transposing the contents of the pterygopalatine fossa (PPF) and V2, as an entrance to the SphS, maxillary sinus (MaxS), and nasal cavity.

METHODS
Five formalin-injected cadaveric specimens were used for this study (10 approaches). A classic pterional approach was performed. An OPC was created through the inferior orbital fissure, between the orbit and the PPF, by transposing the PPF inferiorly. The extent of the OPC was measured using neuronavigation and manual measurements. Two illustrative cases using the OPC to access skull base tumors are presented in the body of the article.

RESULTS
Via the OPC, the SphS, MaxS, ethmoid sinus (EthS), and nasal cavity could be accessed. The use of endoscopic assistance through the OPC achieved better visualization of the EthS, SphS, MaxS, clivus, and nasal cavity. A significant gain in the area of exposure could be achieved using the OPC compared to the AMT (22.4 mm2 vs 504.1 mm2).

CONCLUSIONS
Opening of the AMT and transposition of V2 and the contents of the PPF creates the OPC, a potentially useful deep keyhole to access the paranasal sinuses and clival region through a middle fossa approach. It is a valuable alternative approach to reach deep-seated skull base lesions infiltrating the cavernous sinus and middle cranial fossa and extending into the paranasal sinus.
Complications, outcomes, and management strategies of non-missile penetrating head injuries
Authors: Harrington Bradley M. , Gretschel Armin , Lombard Carl , Lonser Russell R. , Vlok Adriaan J. 
Published: June 2020

OBJECTIVE
While high-velocity missile injury (gunshot) is associated with kinetic and thermal injuries, non-missile penetrating head injury (NMPHI) results in primary damage along the tract of the piercing object that can be associated with significant secondary complications. Despite the unique physical properties of NMPHI, factors associated with complications, expected outcomes, and optimal management have not been defined. In this study, the authors attempted to define those factors.

METHODS
Consecutive adult patients with NMPHI who presented to Tygerberg Academic Hospital (Cape Town, South Africa) in the period from August 1, 2011, through July 31, 2018, were enrolled in a prospective study using a defined treatment algorithm. Clinical, imaging, and laboratory data were analyzed.

RESULTS
One hundred ninety-two patients (185 males [96%], 7 females [4%]) with 192 NMPHIs were included in this analysis. The mean age at injury was 26.2 ± 1.1 years (range 18–58 years). Thirty-four patients (18%) presented with the weapon in situ. Seventy-one patients (37%) presented with a Glasgow Coma Scale (GCS) score of 15. Weapons included a knife (156 patients [81%]), screwdriver (18 [9%]), nail gun (1 [0.5%]), garden fork (1 [0.5%]), barbeque fork (1 [0.5%]), and unknown (15 [8%]). The most common wound locations were temporal (74 [39%]), frontal (65 [34%]), and parietal (30 [16%]). The most common secondary complications were vascular injury (37 patients [19%]) and infection (27 patients [14%]). Vascular injury was significantly associated with imaging evidence of deep subarachnoid hemorrhage and an injury tract crossing vascular territory (p ≤ 0.05). Infection was associated with delayed referral (> 24 hours), lack of prophylactic antibiotic administration, and weapon in situ (p ≤ 0.05). A poorer outcome was associated with a stab depth > 50 mm, a weapon removed by the assailant, vascular injury, and eloquent brain involvement (p ≤ 0.05). Nineteen patients (10%) died from their injuries. The Glasgow Outcome Scale (GOS) score was linearly related to the admission GCS score (p < 0.001). One hundred forty patients (73%) had a GOS score of 4 or better at discharge.

CONCLUSIONS
The most common NMPHI secondary complications are vascular injury and infection, which are associated with specific NMPHI imaging and clinical features. Identifying these features and using a systematic management paradigm can effectively treat the primary injury, as well as diagnose and manage NMPHI-related complications, leading to a good outcome in the majority of patients.
Impact of Cognitive Frailty on Activities of Daily Living, Cognitive Function, and Conversion to Dementia Among Memory Clinic Patients with Mild Cognitive Impairment
Authors: Sugimoto Taiki , Ono Rei , Kimura Ai , Saji Naoki , Niida Shumpei , Sakai Toshihiro , Rakugi Hiromi , Toba Kenji , Sakurai Takashi 
Published: June 2020

Background: Very few studies have investigated the impact of cognitive frailty in clinical settings, especially in memory clinic populations. Objective: To examine the impact of cognitive frailty on activities of daily living (ADL), cognitive function, and conversion to dementia among memory clinic patients with mild cognitive impairment (MCI). Methods: The subjects of this retrospective study were 248 MCI patients (mean age, 76.3±5.4 years; females, 60.9%). All subjects completed a comprehensive geriatric assessment at baseline and at least one assessment during 3-year follow-up. Frailty was defined by generating a frailty index (FI), and MCI patients with frailty (FI≥0.25) were considered to represent cognitive frailty. As primary outcomes, the Barthel Index, Mini-Mental State Examination, and incident dementia were evaluated during follow-up. At baseline, patients were assessed for apolipoprotein E ( APOE) phenotype. A linear mixed model, as well as a Cox proportional hazards regression model with adjustment for confounding variables, was performed. Results: Of these patients, 75 (30.2%) were classified as cognitive frail. APOE ɛ4 carriers accounted for 26.7% of those with cognitive frailty and 44.5% of those without ( p = 0.008). Cognitive frail patients showed a faster ADL decline (estimate, –1.04; standard error, 0.38; p = 0.007) than patients without cognitive frailty. Cognitive frailty was not associated with cognitive decline and incident dementia. Conclusion: Our findings demonstrated cognitive frailty increases the risk of dependence but not cognitive outcomes. Cognitive frailty may have heterogeneous conditions, including APOE ɛ4-related pathologies, which may affect the cognitive trajectories of patients with MCI.
Cerebrospinal Fluid YKL-40 and Neurogranin in Familial Alzheimer’s Disease: A Pilot Study
Authors: Thordardottir Steinunn , Almkvist Ove , Johansson Charlotte , Zetterberg Henrik , Blennow Kaj , Graff Caroline 
Published: June 2020

Background: YKL-40 and neurogranin are promising additional cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) which reflect different underlying disease mechanisms. Objective: To compare the levels of CSF YKL-40 and neurogranin between asymptomatic carriers of familial AD (FAD) mutations (MC) and non-carriers (NC) from the same families. Another objective was to assess changes in YKL-40 and neurogranin, from the presymptomatic to clinical phase of FAD. Methods: YKL-40 and neurogranin, as well as A β42, total tau-protein, and phospho-tau, were measured in the CSF of 14 individuals carrying one of three FAD mutations, APPswe (p.KM670/671NL), APParc (p.E693G), and PSEN1 (p.H163Y), as well as in 17 NC from the same families. Five of the MC developed mild cognitive impairment (MCI) during follow-up. Results: In this pilot study, there was no difference in either CSF YKL-40 or neurogranin when comparing the presymptomatic MC to the NC. YKL-40 correlated positively with expected years to symptom onset and to age in both the MC and the NC, while neurogranin had no correlation to either variable in either of the groups. A subgroup of the participants underwent more than one CSF sampling in which half of the MC developed MCI during follow-up. The longitudinal data showed an increase in YKL-40 levels in the MC as the expected symptom onset approached. Neurogranin remained stable over time in both the MC and the NC. Conclusion: These findings support a positive correlation between progression from presymptomatic to symptomatic AD and levels of CSF YKL-40, but not neurogranin.
Kangaroo mother care can improve the short-term outcomes of very preterm infants
Authors: Pavlyshyn H. , Sarapuk I. , Casper C. , Makieieva N. 
Published: June 2020

BACKGROUND: Kangaroo mother care (KMC) is a cornerstone of preterm infant management. The purpose of this study was to estimate the effectiveness of daily prolonged KMC in very preterm infants and its influence on neonatal morbidity and short-term outcomes, and breastfeeding optimization. METHODS: Research included 52 very preterm infants. According to the KMC duration newborns were divided into two groups; Group1 of 22 infants (42.3%) – KMC lasted more than 3 hours/day, Group 2 of 30 infants (57.7%) – KMC lasted less than 3 hours/day. RESULTS: Nosocomial sepsis occurred less frequently in Group 1 versus Group 2 (OR = 10.50; 95% CI 1.23–89.67, p = 0.012). Incidences of BPD, NEC, IVH I–II grades, the duration of parenteral nutrition, and growth parameters have not been different between groups ( p > 0.05). Breastfeeding rates at discharge prevailed in Group 1 (OR = 3.70; 95% CI 1.16–11.86, p = 0.025). The most important factors for nosocomial sepsis: combination of parenteral nutrition duration and daily prolonged KMC, as a preventing factor ( p = 0.002). Combination of the neonatal intensive care unit (NICU) treatment duration, type of enteral feeding, and mother’s age add as factors that have important influence on breastfeeding prolongation ( p = 0.009). CONCLUSION: Nosocomial infection prevention and breastfeeding optimization are profitable outcomes of daily prolonged KMC in very preterm infants. No significant differences in the BPD, NEC, IVH I–II grades incidences, duration of parenteral nutrition, and growth parameters were found between studied groups. Combination of long-lasting KMC and short-term parenteral nutritionis a significant factor for nosocomial sepsis prophylaxis.
Extubación fallida postoperación de Norwood en pacientes con síndrome de hipoplasia de ventrículo izquierdo
Authors: Herrera J. Adolfo , Springmuller P. Daniel , Del Pozo B. Paulina , Cerda L. Jaime , Adasme J. Rodrigo , Castillo M. Andres 
Published: June 2020

En pacientes con Síndrome de Hipoplasia de Ventrículo Izquierdo (SHVI) la primera etapa hacia una fisiología univentricular de Fontan es la operación de Norwood, cuya mortalidad es 10-30%. En estos pacientes la extubación fallida se presenta en un 18% y se ha asociado a aumento de la mortalidad.Objetivo: Describir la frecuencia de extubación fallida y sus factores de riesgo en pacientes con SHVI operados (Norwood).Pacientes y Método: Estudio de casos y controles que incluyó a todos los pacientes con SHVI manejados con cirugía de Norwood en el Hospital Clínico de la Pontificia Universidad Católica (enero-2000 a febrero-2018). Se define como casos a pacientes con falla en la extubación y como controles a los pacientes sin esta complicación. Se registraron variables demográficas, quirúrgicas, y post-quirúrgicas, y se realizó análisis univariado y multivariado (regresión logística) para determinar los factores de riesgo asociados a la falla en la extubación.Resultados: De un total de 107 pacientes, 26 pacientes tuvieron extubación fallida (24,3%). En el análisis univariado los factores asociados a extubación fallida fueron: mayor tiempo de ventilación mecánica postquirúrgico, desarrollar atelectasias, derrame pleural, quilotórax, tener otras comorbilidades respiratorias (apnea y traqueítis), y mayor tiempo de uso de morfina y midazolam. En el análisis multivariado, la presencia de quilotórax, otras comorbilidades respiratorias, y mayor tiempo de uso de midazolam fueron variables asociadas a extubación fallida (p<0,03). La extubación fallida no se asoció a mayor mortalidad.Conclusiones: La presencia de quilotórax, complicaciones respiratorias y uso de midazolam prolongado deben considerarse para definir el momento de la extubación, con el objetivo de evitar su fracaso.
Un programa de prevención temprana de la obesidad: “HaViSa UC” (2009-2019)
Authors: S. Barja , M. Loyola , C. Ortiz , Y. Araneda , R. Undurraga 
Published: June 2020

Introducción: La prevención es la solución definitiva al grave problema epidemiológico nutricional de la niñez en nuestro país y el mundo, que es la obesidad.Objetivo: Describir los resultados de un programa de prevención de la obesidad en lactantes y preescolares, a diez años de su inicio.Sujetos y Método: Estudio retrospectivo, cuasi experimental, de la prevalencia de sobrepeso y obesidad, en niños y niñas asistentes a las salas-cuna y jardines infantiles de la Universidad Católica de Chile, desde la implementación en 2009 de un programa de promoción precoz de hábitos de vida saludable en alimentación y actividad física (HaViSa-UC), hasta 2019. Se obtuvo aprobación ética y se analizaron los registros anuales de las evaluaciones antropométricas (referencia OMS 2006), de cada mes de marzo, en los centros de tres campus universitarios, utilizando el programa Minitab 17. Las acciones implementadas por el HaViSa-UC fueron: evaluación del estado nutricional y comunicación con los padres, entrega de una alimentación saludable, promoción de un hábito activo de vida y educación para favorecer hábitos saludables de vida. Resultados: El promedio anual fue de 319 asistentes, 14% menores de dos años y 49,5% niñas. En marzo 2009 se detectó 32,6% de sobrepeso y 8,6% de obesidad, cifras que disminuyeron y se estabilizaron, alcanzando en marzo de 2019 a 23,8% y 4,7% respectivamente. Los eutróficos aumentaron desde 56,9% a 67,4%, sin aumentar el bajo peso. En el mismo período, zP/T bajó desde 0,84 ± 0,94 a 0,55 ± 0,87 (p=0,00), y zT/E aumentó desde -0,36 ± 0,87 a -0,32 ± 0,90 (p>0,05).Conclusión: Desde la implementación del programa HaViSa, en esta muestra de lactantes y preescolares la frecuencia de obesidad bajó en 45,4% y el sobrepeso en 27%, con estabilidad al cabo de diez años.
<i>Utopia</i>’s Moorish Inspiration: Thomas More’s Reading of Ibn Ṭufayl
Authors: Regnier Daniel 
Published: June 2020

A promising but neglected precedent for Thomas More’s Utopia is to be found in Ibn Ṭufayl’s Ibn Ḥayy Yaqẓān. This twelfth-century Andalusian philosophical novel describing the self-education and enlightenment of a feral child on an island, while certainly a precedent for the European Bildungsroman, also arguably qualifies as a utopian text. It is possible that More had access to Pico de la Mirandola’s Latin translation of Ibn Ḥayy Yaqẓān. This study consists of a review of historical and philological evidence that More may have read Ibn Ḥayy Yaqẓān and a comparative reading of More’s and Ṭufayl’s two famous works. I argue that there are good reasons to see in Ibn Ḥayy Yaqẓān a source for More’s Utopia and that in certain respects we can read More’s Utopia as a response to Ṭufayl’s novel.
L’Ibn Ḥayy Yaqẓān d’Ibn Ṭufayl consiste en un précédent incontournable mais négligé à l’Utopie de More. Ce récit philosophique andalou du douzième siècle décrivant l’auto-formation et l’éveil d’un enfant sauvage sur une île peut être considéré comme un texte utopique, bien qu’il soit certainement un précédent pour le Bildungsroman européen. Thomas More pourrait avoir lu l’Ibn Ḥayy Yaqẓān, puisqu’il a pu avoir accès à la traduction latine qu’en a fait Pic de la Miradolle. Cette étude examine les données historiques et philologiques permettant de poser que More a probablement lu cet ouvrage, et propose une lecture comparée de l’Ibn Ḥayy Yaqẓān et de l’Utopie de More. On y avance qu’il y a non seulement de bonnes raisons de considérer l’Ibn Ḥayy Yaqẓān d’Ibn Ṭufayl comme une source de l’Utopie de More, mais qu’il est aussi possible à certains égards de lire l’Utopie comme une réponse à l’Ibn Ḥayy Yaqẓān.
More, Huxley, Eggers, and the Utopian/Dystopian Tradition
Authors: Herman Peter C. 
Published: June 2020

From its inception in Plato’s Republic and revival in Thomas More’s Utopia, the concept of a perfect (or as More originally put it in a qualification often lost, “best”) form of a republic has been dogged by the spectres of hypocrisy, contradiction, and authoritarianism. However, the matter is more complicated than a simple declaration that utopias provide a vehicle for totalitarian fantasy, that totalitarian governments inevitably portray themselves as creating a utopia. While today’s readers, at a comfortable distance from the early sixteenth century, may bridle at the lack of privacy, or at the ideological coerciveness in More’s Utopia, that does not eradicate how, in Walter Kendrick’s words, “what for us are problems are for them solutions.” It can be argued that the negative elements are a response to social ills. The same goes for Aldous Huxley’s Brave New World and Dave Eggers’s The Circle. While the negatives in all three fictions undermine or put into question the positives, our realization that the authors also intended the negatives as genuine attempts at resolving genuine problems that cause untold misery invites us to complicate our judgments. The undermining is itself undermined.
L’idée d’un gouvernement parfait (ou « meilleur » pour reprendre l’expression même de More), de son apparition dans la République de Platon jusqu’à son renouveau dans l’Utopie de Thomas More, a été traquée et mise à profit par les partisans de l’hypocrisie, de la contradiction et de l’autoritarisme. Toutefois, la question est plus complexe que la simple affirmation qui voudrait que les utopies favorisent les phantasmes totalitaires, ou que les gouvernements totalitaires se présentent inévitablement comme la réalisation d’une utopie. Ces éléments négatifs répondent en fait souvent à de véritables problèmes sociaux, et, bien que le lecteur d’aujourd’hui, dans la confortable distance qui le sépare du début du XVIe siècle, puisse s’indigner du manque de vie privée et de l’intransigeance idéologique de l’Utopie de More, cela ne change pas le fait que, pour emprunter la formule de Walter Kendrick, « ce qui pour nous sont des problèmes, sont pour eux des solutions ». Il en va de même pour le Brave New World de Aldous Huxley et The Circle de Daver Egger. Alors que les aspects négatifs dans ces trois fictions compromettent leurs aspects positifs, le fait de reconnaître que ces auteurs, par ces moyens discutables, ont sincèrement tenté de régler de vrais problèmes entraînant des misères infinies, amène le lecteur d’aujourd’hui à nuancer ses jugements. Et ainsi, les aspects compromettants de ces oeuvres sont eux-mêmes remis en question.
PM<sub>2.5</sub> concentration and meteorological characteristics in Dhaka, Bangladesh
Authors: Razib - , Nayeem AA , Hossain MS , Majumder AK 
Published: June 2020

Air quality in Dhaka city is gradually deteriorating due to increase of pollutants in air. This study aims to assess the concentration of particulate matter (PM) with an aerodynamic diameter ≤2.5 μm (PM2.5) and its relationship with meteorological parameters in highly polluted Dhaka city. Data for PM2.5 has been collected from the Air Now Department of State (AirNow DOS) and meteorological data from Bangladesh Meteorological Department (BMD). Study observed that 31.9% of hourly Air Quality Index (AQI) category was unhealthy while the percentage of ‘Good’ was very few. The maximum monthly average concentration was found to be 192.97±89.30 μg/m3 in the month of January while minimum average concentration was 29.98±19.37 μg/m3 in July. Besides, it also found that winter season had highest PM2.5concentration among all seasons. Moreover, the annual concentration was found to be 79.94±75.55 μg/m3 in 2017 which exceeded the National Ambient Air Quality Standard (NAAQS) and World Health Organization (WHO) standard. A number of meteorological factors are affecting to this variation. It is also found that rainfall is negatively strong and significantly correlated with the concentration of PM2.5, due to ambient dust are being settle down in the lithosphere. Annual concentration of PM2.5 was 5 times higher than standard level.
Bangladesh J. Sci. Ind. Res.55(2), 89-98, 2020
Polycyclic aromatic hydrocarbons in the atmosphere of Data Darbar Chowk of Lahore, Pakistan
Authors: Kalim I , Zahra N , Saeed MK , Gilani R , Munawar A , Jalees MI 
Published: June 2020

PAHs (polycyclic aromatic hydrocarbons) in atmosphere are amongst the hazardous identified organic pollutants. The present study was conducted on the determination of PAHs concentrations in the air of Data Darbar Chowk, Lahore, Pakistan. The particulate matters in the atmosphere were collected using high volume samplers. Average Total Particulate Matter (mg) of PM2.5was 20.96 and PM10was 188.7. The concentration of PM2.5was 698.81 ngm-3/hr and 16771 ngm-3/day while concentration of PM10was 6290 ngm-3/hr and 150960 ngm-3/day. Quantification of different PAHs and related compounds was done by using Gas Chromatography. The mean total quantity of PAH in air was 955.588 ngm-3. The mean concentration of dibenzo (a, h) anthracene was highest i.e. 161.33 ngm-3with 13.94 ngm-3 Minimum and 308.72 ngm-3Maximum, concentrations. PAHs concentration was found to be very high in current research. There should be proper control through air management system to tackle with harmfulness of health hazardous organic pollutants.
Bangladesh J. Sci. Ind. Res.55(2), 147-152, 2020
Perkembangan Fasies Sedimen Formasi Mamberamo Berumur Miosen Akhir-Pliosen di Cekungan Papua Utara
Authors: Mamengko David Victor , B.Sendjadja Yoga , Mulyana Budi , Panggabean Hermes , Haryanto Iyan , Lelono Eko Budi , Musu Juwita Trivianty , Panuju Panuju 
Published: June 2020

North Papua Basin is a fore arc basin located in northern coastal of Papua Island. This basin filled by Middle-Upper Miocene turbidite sediment and overlied by Upper Miocene – Quarternary clastic sediment. Upper Miocene – Quaternary clastic sediments (Mamberamo Formation) composed by interbedding conglomerate, sandstone and shale as molasses deposit. A detailed stratigraphic study was performed to identify facies and its association of the Mamberamo Formation to that give a new perspective on the characteristics and development of facies succession of Lower Mamberamo Formation. Result shows that the Lower Mamberamo Formation consists of three facies: A) cross bedding sandstone (subtidal), B) heterolothic silty shale (intra-tidal), C) carbonaceous shale (supra-tidal) deposited on Late Miocen to Plio-Pleistocene during centra range orogeny (syn-orogeny) as molasses deposits.Keywords: Fore arc basin, North Papua Basin, Mamberamo Formation, molasse deposits.