bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abemaciclib, a CDK4/6 inhibitor, exerts preclinical activity against aggressive germinal center‐derived B‐cell lymphomas
Authors: Tanaka Yuka , Momose Shuji , Tabayashi Takayuki , Sawada Keisuke , Yamashita Takahisa , Higashi Morihiro , Sagawa Morihiko , Tokuhira Michihide , Rosenwald Andreas , Kizaki Masahiro , Tamaru Jun‐ichi 
Published: December 2019

AbstractThe revised WHO classification newly defined the entities “High‐grade B‐cell lymphoma with MYC and BCL2, and/or BCL6 rearrangements (HGBL‐DH/TH)” and “HGBL, NOS.” Standard immunochemotherapy for diffuse large B‐cell lymphoma (DLBCL), R‐CHOP, is insufficient for HGBL patients, and there are currently no optimized therapeutic regimens for HGBL. We previously reported that CCND3, which encodes cyclin D3, harbored high mutation rates in Burkitt lymphoma (BL), HGBL and a subset of DLBCL. Furthermore, the knockdown of cyclin D3 expression was toxic to germinal center (GC)‐derived B‐cell lymphomas. Thus, the fundamental function of cyclin D3 is important for the pathogenesis of GC‐derived B‐cell lymphoma. We herein used two structurally different CDK4/6 inhibitors, palbociclib and abemaciclib, and examined their suppressive effects on cell proliferation and their ability to induce apoptosis in various aggressive B‐cell lymphoma cell lines. The results obtained demonstrated that abemaciclib more strongly suppressed cell proliferation and induced apoptosis in GC‐derived B‐cell lymphoma cell lines than the control, but only slightly inhibited those features in activated B‐cell (ABC)‐like DLBCL cell lines. Palbociclib exerted partial or incomplete effects compared with the control and the effect was intermediate between abemaciclib and the control. Moreover, the effects of abemaciclib appeared to depend on cyclin D3 expression levels based on the results of the expression analysis of primary aggressive B‐cell lymphoma samples. Therefore, abemaciclib has potential as a therapeutic agent for aggressive GC‐derived B‐cell lymphomas.
YES1 activation induces acquired resistance to neratinib in HER2‐amplified breast and lung cancers
Authors: Takeda Tatsuaki , Yamamoto Hiromasa , Suzawa Ken , Tomida Shuta , Miyauchi Shunsaku , Araki Kota , Nakata Kentaro , Miura Akihiro , Namba Kei , Shien Kazuhiko , Soh Junichi , Shien Tadahiko , Kitamura Yoshihisa , Sendo Toshiaki , Toyooka Shinichi 
Published: December 2019

AbstractMolecular‐targeted therapies directed against human epidermal growth factor receptor 2 (HER2) are evolving for various cancers. Neratinib is an irreversible pan‐HER tyrosine kinase inhibitor and has been approved by the FDA as an effective drug for HER2‐positive breast cancer. However, acquired resistance of various cancers to molecular‐targeted drugs is an issue of clinical concern, and emergence of resistance to neratinib is also considered inevitable. In this study, we established various types of neratinib‐resistant cell lines from HER2‐amplified breast and lung cancer cell lines using several drug exposure conditions. We analyzed the mechanisms of emergence of the resistance in these cell lines and explored effective strategies to overcome the resistance. Our results revealed that amplification of YES1, which is a member of the SRC family, was amplified in two neratinib‐resistant breast cancer cell lines and one lung cancer cell line. Knockdown of YES1 by siRNA and pharmacological inhibition of YES1 by dasatinib restored the sensitivity of the YES1‐amplified cell lines to neratinib in vitro. Combined treatment with dasatinib and neratinib inhibited tumor growth in vivo. This combination also induced downregulation of signaling molecules such as HER2, AKT and MAPK. Our current results indicate that YES1 plays an important role in the emergence of resistance to HER2‐targeted drugs, and that dasatinib enables such acquired resistance to neratinib to be overcome.
Long‐term outcomes of the implants accidentally protruding into nasal cavity extended to posterior maxilla due to inferior meatus pneumatization
Authors: Park Won‐Bae , Kim Young‐Jin , Kang Kyung Lhi , Lim Hyun‐Chang , Han Ji‐Young 
Published: December 2019

AbstractBackgroundThere is limited information about inferior meatus pneumatization in terms of implant treatment for the posterior maxilla.PurposeTo demonstrate the clinical, radiologic, and nasal endoscopic outcomes of implants accidentally protruding into the nasal cavities with inferior meatus pneumatization in the posterior maxilla.Materials and MethodsA total of 560 implants (324 patients) with transcrestal sinus augmentation in the posterior maxilla were screened. On panoramic radiographs, 132 implants (78 patients) appear to penetrate the sinus floor, but cone‐beam computed tomography demonstrated that 26 implants (13 patients) penetrated the nasal floor due to inferior meatus pneumatization. Width of nasal and sinus cavities and extent of penetration were radiographically measured. Nasal endoscopy was performed.ResultsTwo implants were lost during 13.81 ± 5.40 years due to peri‐implantitis. However, no nasosinusal problem occurred in any patient. The nasal cavity was significantly larger in patients with implants penetrating the pneumatized inferior meatus than in those with implants penetrating the sinus floor (P< .05). Nasal endoscopy demonstrated that the apical portion of the implants was covered with thin mucosa without inflammation.ConclusionImplants accidentally penetrating the pneumatized inferior meatus demonstrated high survival with no specific nasosinusal complications. Inferior meatus pneumatization should be considered for implant treatment in the posterior maxilla.
Green synthesis of reactive dye for ink‐jet printing
Authors: Faisal Saira , Lin Long 
Published: December 2019

AbstractChloropyrimidine‐based reactive dyes are reported as well suited to textile printing; however, nucleophilic aromatic substitution of chloropyrimidines with amino‐containing chromophores is slow and often suffers from poor yields. In this study, a novel and simple method was developed for the synthesis of chloropyrimidine‐based reactive dye under microwave irradiation. In addition, the dye was also synthesised by conventional heating for comparison, which took both the reaction time and yield into account. The progress of the synthesis reactions concerned were monitored using capillary electrophoresis and the purity of the dye obtained was assessed by thin‐layer chromatography. The structure of the synthesised trichloropyrimidine dye was confirmed by Fourier Transform–infrared spectroscopy and elemental analysis. It was found that the reaction rate of the nucleophilic aromatic substitution carried out under microwave irradiation was 4‐fold faster than that carried out under conventional heating, although the enhancement in product yield was modest. These results suggest that microwave irradiation is an effective technique for the synthesis of chloropyrimidine‐based reactive dyes. The synthesised chloropyrimidine dye was formulated into an ink and applied onto a wool fabric by ink‐jet printing. The printed fabrics were steamed at 102°C for 5‐25 minutes at 5‐minute intervals. Good K/S and rate of dye fixation were obtained, both of which improved with increasing steaming time. The prints obtained exhibited reasonably good light and wash fastness properties.
Diagnosis of pyridoxine‐dependent epilepsy in an adult presenting with recurrent status epilepticus
Authors: Osman Chinar , Foulds Nicola , Hunt David , Jade Edwards Casidhe , Prevett Martin 
Published: December 2019

AbstractPyridoxine‐dependent epilepsy (PDE) is a genetic metabolic disease caused by inborn errors affecting vitamin B6 metabolism, which typically presents with neonatal seizures resistant to antiepileptic drugs (AEDs). Treatment with pyridoxine terminates seizures and prevents neurological decline. We describe a case in which the diagnosis was established at the age of 22 years. Birth and development were normal, but there was a history of three isolated tonic‐clonic seizures during childhood and adolescence. At the age of 18 years, she developed frequent focal motor seizures, many evolving into tonic‐clonic seizures. Electroencephalography identified a focus in the posterior right hemisphere, but magnetic resonance imaging of the brain was normal. Over the next 3 years, she was hospitalized with uncontrolled seizures on six occasions and spent a total of 121 days in intensive care. The seizures proved resistant to 12 different AEDs. Exome sequencing revealed two pathogenic mutations in ALDH7A1. Since starting on pyridoxine 50 mg once daily, she has been seizure‐free, all AEDs have been withdrawn, and cognition has improved to premorbid levels. This case illustrates the importance of considering PDE in drug‐resistant epilepsy in adults.
Effect of multiaxial stress state on creep damage in ASME T92 welded joint
Authors: Wang Xiao , Wang Xue , Wang Chuang , Zhang Ya‐Lin , Huang Qiao‐Sheng 
Published: December 2019

AbstractThis study reports the type IV fracture process and the influence of multiaxial stress state in ASME T92 welded joints during creep. The type IV fracture occurs at the fine‐grained heat‐affected zone (ie, FGHAZ), involving void initiation, growth, and coalescence, microcrack occurrence, propagation and extension, and eventual macrocrack with consequent joint failure. The creep damage is not uniformly distributed along the thickness direction in the FGHAZ, and the central part of the welded joint is the most seriously damaged region. The equivalent creep strain is higher at the external surface, but the stress triaxiality is larger in the centre section. Large equivalent creep strain could promote creep void initiation, whereas high hydrostatic pressure and stress triaxiality factor accelerate void growth in the FGHAZ of T92 joints. Besides, reducing groove angle and HAZ width of the joints is recommended to delay the occurrence of type IV cracking because of lower equivalent creep strain and stress triaxiality factor.
Maintaining historic disturbance regimes increases species' resilience to catastrophic hurricanes
Authors: Henry Erica H. , Burford Reiskind Martha O. , Land Aerin D. , Haddad Nick M. 
Published: December 2019

AbstractAs habitat loss and fragmentation, urbanization, and global climate change accelerate, conservation of rare ecosystems increasingly relies on human intervention. However, any conservation strategy is vulnerable to unpredictable, catastrophic events. Whether active management increases or decreases a system's resilience to these events remains unknown. Following Hurricane Irma's landfall in our habitat restoration study sites, we found that rare ecosystems with active, human‐imposed management suffered less damage in a hurricane's path than unmanaged systems. At the center of Irma's landfall, we found Croton linearis' (a locally rare plant that is the sole host for two endangered butterfly species) survival and population growth rates in the year of the hurricane were higher in previously managed plots than in un‐managed controls. In the periphery of Irma's circulation, the effect of prior management was stronger than that of the hurricane. Maintaining the historical disturbance regime thus increased the resilience of the population to major hurricane disturbance. As climate change increases the probability and intensity of severe hurricanes, human management of disturbance‐adapted landscapes will become increasingly important for maintaining populations of threatened species in a storm's path. Doing nothing will accelerate extinction.
Non‐destructive prediction of forage crop moisture contents using microwave transmitted signals with a microstrip transmission line sensor
Authors: Matsuo Morinobu , Osada Akira , Kon Seitaro 
Published: December 2019

AbstractThis paper describes a non‐destructive method for using microwave transmitted signals to measure the moisture content of silage wrapped with plastic films. To collect measurements by a vector network analyzer, each bag of silage was placed on a microstrip transmission line without destruction of the films. Both rye and corn were tested. Significant linear relationships between the amplitude change (ΔA) and phase shift (Δφ) were obtained except for with fully dried corn, and the corresponding R2 values between ΔA and Δφ were 0.8 or greater. The slopes, which represent the ratio of phase shift to amplitude change (Δφ–ΔA ratio), depended on the frequency and moisture content. R2 values between the Δφ–ΔA ratio and moisture content of rye and corn were greater than 0.8 at the frequency of 3.6 GHz or above except for with fully dried corn samples. At 3.6 GHz, significant linear relationships between the Δφ–ΔA ratio and moisture content were obtained for rye and corn. Furthermore, the slope and intercept of the linear regression line between the Δφ–ΔA ratio and moisture content of rye were not significantly different from those of corn. These results illustrate the potential of the non‐destructive moisture content measurement method with microwave transmitted signals for silage materials with high moisture contents.
Cardiovascular disease risk and its determinants in people living with HIV across different settings in South Africa
Authors: Roozen G V T , Vos A G , Tempelman H A , Venter W D F , Grobbee D E , Scheuermaier K , Klipstein‐Grobusch K 
Published: December 2019

ObjectivesSocio‐economic factors and lifestyle are known to differ across geographies and populations, which may result in distinct risk profiles for cardiovascular disease (CVD). This study assessed carotid intima‐media thickness (CIMT), a proxy for CVD, and its determinants in two groups of people living with HIV (PLHIV) in two different settings in South Africa.MethodsA cross‐sectional analysis was conducted comparing data from the Ndlovu Cohort Study in the Limpopo Province (group 1) and from three clinical trials in Johannesburg (group 2). The association between demographics, conventional CVD risk factors, HIV‐related factors and CIMT in groups 1 and 2 was analysed with two separate multivariable linear regression models.ResultsGroup 1 consisted of 826 participants (mean age 42.2 years) and mean (± standard deviation) CIMT was 0.626 ± 0.128 mm. In this group, sex, age, body mass index (BMI), cholesterol, glucose and antiretroviral therapy (ART) duration (β = 0.011 mm per 5 years; P = 0.02) were associated with higher CIMT. There were positive interactions between age and ART duration and age and cholesterol. Group 2 consisted of 382 participants (mean age 39.5 years) and mean (± standard deviation) CIMT was 0.560 ± 0.092 mm. In this group, only sex, education level, BMI and cholesterol were associated with higher CIMT, albeit with weaker associations than in group 1.ConclusionsConventional CVD risk factors were the main drivers of CIMT. The impact of some of these risk factors appeared to increase with age. Differences in sample size, age and viral suppression might explain why an effect of ART was observed in group 1 but not in group 2.
Distribution of ductile deformation around the Main Central Thrust zone at the frontal part of nappe in southeastern Nepal Himalaya
Authors: Sato Katsushi , Sakai Harutaka , Kawakami Tetsuo 
Published: December 2019

AbstractA geological survey and morphological analysis of quartz grains were performed to investigate the distribution of ductile deformation caused by the Himalayan Main Central Thrust (MCT) around Dhankuta, southeastern Nepal. The MCT was mapped as the lithological boundary between the gneiss of the Higher Himalayan Crystalline (HHC) as the hanging wall and the inverted metamorphic sequence of the Lesser Himalayan Sediments (LHS) as the footwall. The MCT was found to truncate various stratigraphic levels of LHS and cuts a map‐scale gentle fold developed in the LHS. Ductile deformation was quantified by fractal dimension between size and perimeter of dynamically recrystallized quartz grains in bedded metaquartzite intercalated in both HHC and LHS. Serrate and polygonal shapes of quartz indicate large and small strain rates, respectively, when the temperature during ductile deformation was assumed to be uniform. A peak of strain rate was found at the lithological boundary with the peak width of ca. 500 m. Such a thin shear zone is favorable for producing frictional heat to promote the inverted metamorphism in LHS.
First mover advantage by product proliferation in multiproduct duopoly
Authors: Cheng Yi‐Ling , Tabuchi Takatoshi 
Published: December 2019

AbstractThis study aims to show that the product proliferation strategy in multi‐product duopoly is first‐mover advantage. We consider simultaneous and Stackelberg variety competitions. A firm producing more varieties charges a higher price, produces larger total quantities, and earns higher total revenue. When firms sequentially choose the masses of varieties and then simultaneously decide prices, the leader produces more varieties and enjoys first‐mover advantage. The masses of varieties can be regarded as strategic substitutes in the same way that quantities are. Finally, the market is likely to provide too few varieties relative to the social optimum.
Application of the novel Droplet digital PCR technology for identification of meat species
Authors: Basanisi Maria Grazia , La Bella Gianfranco , Nobili Gaia , Coppola Rosa , Damato Annita Maria , Cafiero Maria Assunta , La Salandra Giovanna 
Published: December 2019

AbstractThe authenticity and traceability of meat products are issues of primary importance to ensure food safety. Unfortunately, food adulteration (e.g. the addition of inexpensive cuts to minced meat products) and mislabelling (e.g. the inclusion of meat from species other than those declared) happens frequently worldwide. The aim of this study was to apply a droplet digital PCR assay for the detection and quantification (copies μL−1) of the beef, pork, horse, sheep, chicken and turkey in meat products. The analysis conducted on commercial meat showed the presence of traces of DNA from other animal species than those declared. We show that the method is highly sensitive, specific and accurate (accuracy = 100%). This method could be adopted by competent food safety authorities to verify compliance with the labelling of meat products and to ensure quality and safety throughout the meat supply chain, from primary production to consumption.
Nurse staffing, nurses prioritization, missed care, quality of nursing care, and nurse outcomes
Authors: Cho Sung‐Hyun , Lee Ji‐Yun , You Sun Ju , Song Kyung Ja , Hong Kyung Jin 
Published: December 2019

AbstractAimTo examine the relationships among nurse staffing, nurses prioritization of nursing activities, missed care, quality of nursing care, and nurse outcomes.BackgroundInadequate staffing is associated with increased missed care, which threatens the quality of care and nurse outcomes.MethodsThe study sample included 2114 staff nurses from 156 medical or surgical units of 49 general hospitals who had participated in a cross‐sectional survey conducted in 2015. Nurse staffing was measured using the patient‐to‐nurse ratio and perceived staffing adequacy. The Missed Nursing Care Survey was used to measure how frequently nurses had missed each of 24 activities. Multilevel regression analyses were employed to examine the relationships among variables.ResultsThe prevalence of missed care differed by nursing activity. Poorer staffing was associated with an increased number of missed activities. A higher number of missed activities and poorer staffing were associated with poorer patient safety, quality of nursing care and job satisfaction, and a higher intent to leave. Nurses gave the highest priority to focused patient reassessments, timely medications, and patient teaching, under hypothetical conditions of improved staffing.ConclusionAdequate staffing is required to reduce missed care and to improve quality of care and nurse outcomes.
Patient education materials on pressure injury prevention in hospitals and health services in Victoria, Australia: Availability and content analysis
Authors: Team Victoria , Bouguettaya Ayoub , Richards Catelyn , Turnour Louise , Jones Angela , Teede Helena , Weller Carolina D. 
Published: December 2019

AbstractPressure injuries (PIs) are a common quality indicator for hospital care, and preventing PIs often requires patient engagement; as such, Australian consensus research has recommended that high‐quality education materials be made to patients for PIs via hospital networks. The purpose of the present study was to assess the availability and accuracy of patient education materials on PIs in publicly available hospital websites in Victoria, Australia. Two independent coders assessed 212 websites for content on PI prevention and management, analysing availability and accuracy of PI definitions, risk factors, preventive strategies, referral, visual tools, consumer endorsement, information for family/carers, and translation on community languages. A greater proportion of hospitals did not have any patient education materials on PI prevention publicly available, with private hospitals (compared with public) and metropolitan hospitals (compared to rural) more likely to have materials available on their sites. The available materials contained accurate messages on PI defining characteristics and risk factors for PIs, although there was considerable variability on the availability of other information. Our findings suggest a significant deficit in the availability of educational materials for acute care patients and their families. There is a need for evidence‐based, consumer‐endorsed, uniform materials on all hospital websites to prevent PIs in acute care.
Incidence and risk factors for medical device‐related pressure ulcers: The first report in this regard in Iran
Authors: Rashvand Farnoosh , Shamekhi Lida , Rafiei Hossein , Nosrataghaei Mohammad 
Published: December 2019

AbstractFew studies, especially among developing countries such as Iran, have been conducted on the incidence and risk factors for medical device‐related pressure ulcers (MDRPUs). Given the importance of this issue and the lack of previous studies, the present study aimed to investigate the incidence and risk factors for MDRPUs in Iran. The present descriptive‐analytical study was conducted at three hospitals in Qazvin, Iran, from June 1, 2019, to September 1, 2019. Data collection took approximately 3 months from July to September 2019. Sampling was carried out through a convenience sampling method, and the samples consisted of 404 patients. For data collection, a checklist for demographic variables, a checklist for patient‐connected medical devices, Braden Scale, Glasgow Coma Scale, National Pressure Ulcer Advisory Panel Pressure Grading Scale, and Nutrition Risk Screening 2002 were used. Of the 404 patients studied, 20.54% (n = 83) developed some degree of MDRPUs. From those, 61 (70.11%) were in stage I, 17 (19.5%) were in stage II, and 9 (10.34%) were in stage III. Among the nine medical devices that caused pressure ulcers, the most commonly reported ones were nasal oxygen tubes (31 cases), oxygen face masks (23 cases), and endotracheal tubes (17 cases). The mean score of Braden Scale (P = .004), the mean score of NRS 2002 (P = .037), older age (P = .007), male gender (P = .002), the average length of stay in hospitals (P = .001), and having pressure ulcers in body (P = .025) significantly increased the possibility of occurring MDRPUs. In the present study, the incidence of MDRPUs was high. Taking the necessary measures into consideration in order to prevent the MDRPUs is essential in Iranian hospitals. Further studies in this regard are strongly recommended.