bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncertainty and grey data analytics
Authors: Yang Yingjie , Liu Sifeng , Xie Naiming 
Published: December 2019

Purpose
The purpose of this paper is to propose a framework for data analytics where everything is grey in nature and the associated uncertainty is considered as an essential part in data collection, profiling, imputation, analysis and decision making.

Design/methodology/approach
A comparative study is conducted between the available uncertainty models and the feasibility of grey systems is highlighted. Furthermore, a general framework for the integration of grey systems and grey sets into data analytics is proposed.

Findings
Grey systems and grey sets are useful not only for small data, but also big data as well. It is complementary to other models and can play a significant role in data analytics.

Research limitations/implications
The proposed framework brings a radical change in data analytics. It may bring a fundamental change in our way to deal with uncertainties.

Practical implications
The proposed model has the potential to avoid the mistake from a misleading data imputation.

Social implications
The proposed model takes the philosophy of grey systems in recognising the limitation of our knowledge which has significant implications in our way to deal with our social life and relations.

Originality/value
This is the first time that the whole data analytics is considered from the point of view of grey systems.
Emotion-regulation strategies in older people: a systematic review
Authors: Ramirez-Ruiz Blanca , Quinn Kathryn , Ferreira Nuno 
Published: December 2019

Purpose
Emotion regulation (ER) has been identified as an important factor influencing psychological and health problems of adult populations. The purpose of this paper is to address a gap in the literature by examining available evidence relating to the use of ER strategies (avoidance, problem solving, reappraisal, rumination and suppression) on the well-being of older people (OP).

Design/methodology/approach
A systematic search for peer-reviewed articles published from 1985 to 2015 was conducted in PsycINFO, CINAHL, Medline, Psychological and Behavioural Sciences Collections and ASSIA and resulted in 1746 titles. In total, 20 studies met full inclusion criteria (the cross-sectional association between well-being and ER was reported, participants were 60 years or older, without cognitive impairment and the article was written in English, Portuguese or Spanish).

Findings
Rumination was found to be the ER strategy most strongly associated with symptoms of anxiety and depression in OP populations, while mixed result were found for avoidance, problem solving, suppression and reappraisal.

Research limitations/implications
Given the scarcity of research examining the association between ER and positive psychological concepts only a conclusion about ER and negative mood measures could be made. Questions for future research on ER and well-being in OP are proposed.

Originality/value
This paper addresses a significant gap in the literature regarding the use of ER strategies in older adults.
Immunogenicity and contraceptive efficacy of recombinant fusion protein encompassing Sp17 spermatozoa‐specific protein and GnRH: Relevance of adjuvants and microparticles based delivery to minimize number of injections
Authors: Minhas Vidisha , Kumar Robin , Moitra Trisha , Singh Rita , Panda Amulya K. , Gupta Satish Kumar 
Published: December 2019

AbstractProblemRequirement of multiple injections of contraceptive vaccines to achieve infertility is one of the important impediments for their application. In the present study, attempts have been made to reduce the number of injections of contraceptive vaccine.Method of studyFusion protein encompassing C‐terminus fragment of sperm protein Sp17 (aa residues 76‐126) and two copies of gonadotropin‐releasing hormone along with T‐cell epitopes and dilysine linkers (abbreviated as Sp17C‐GnRH2) was expressed in Escherichia coli. Its immunogenicity and contraceptive efficacy have been evaluated in female FVB/J mice using different adjuvants and delivery platforms.ResultsImmunization of female mice with recombinant Sp17C‐GnRH2 (25 μg/injection/mouse) emulsified with squalene‐arlacel A following two injections schedule led to failure of 88.8% immunized animals to conceive, which was not significantly different from mice immunized with same protein along with alum following three injections schedule. To make single‐dose vaccine, poly d,l‐lactic acid–based microparticles (PLA‐MPs) entrapping Sp17C‐GnRH2 were prepared. Immunization of female mice with a combination of soluble Sp17C‐GnRH2 (12.5 μg/injection/mouse) along with Sp17C‐GnRH2 entrapped in PLA‐MPs (12.5 μg/injection/mouse) in alum showed higher antibody titres and contraceptive efficacy as compared to mice immunized with Sp17C‐GnRH2 entrapped in PLA‐MPs alone in alum. Immunization with recombinant Sp17C‐GnRH2 led to long‐term infertility as second mating (150 days after immunization) of various groups of immunized mice showed similar infertility as observed during first mating.ConclusionSingle‐dose immunization with PLA‐MPs entrapping Sp17C‐GnRH2 along with soluble recombinant protein in alum generated long‐lasting infertility in female mice.
Effect of BIN1 on cardiac dysfunction and malignant arrhythmias
Authors: Jiang Xiao‐Xin , Zhu Yan‐Rong , Liu Hong‐Ming , Chen Shao‐Liang , Zhang Dai‐Min 
Published: December 2019

AbstractHeart failure (HF) is the end‐stage syndrome for most cardiac diseases, and the 5‐year morbidity and mortality of HF remain high. Malignant arrhythmia is the main cause of sudden death in the progression of HF. Recently, bridging integrator 1 (BIN1) was discovered as a regulator of transverse tubule function and calcium signalling in cardiomyocytes. BIN1 downregulation is linked to abnormal cardiac contraction, and it increases the possibility of malignant arrhythmias preceding HF. Because of the detectability of cardiac BIN1 in peripheral blood, BIN1 may serve as a predictor of HF and may be useful in therapy development. However, the mechanism of BIN1 downregulation in HF and how BIN1 regulates normal cardiac function under physiological conditions remain unclear. In this review, recent progress in the biological studies of BIN1‐related cardiomyocytes and the effect of cardiac dysfunction and malignant arrhythmia will be discussed.
Numerical and experimental validation of residual stresses of laser‐welded joints and their influence on the fatigue behaviour
Authors: Sepe Raffaele , Wiebesiek Jens , Sonsino Cetin Morris 
Published: December 2019

AbstractIn this work laser‐welded tube‐tube specimens made of aluminium alloys AlMg3.5Mn and AlSi1MgMn T6 were experimentally tested under constant and variable amplitude loading, under pure axial and pure torsion loading. In order to evaluate the influence on fatigue behaviour of the residual stresses, because of the welding process, some specimens were subjected to postweld heat treatment and then were tested. The numerical analyses, using finite element (FE), were carried out to obtain a reliable estimation of the residual stress in the specimen. The numerical results were in a good agreement with experimental ones obtained by means of hole‐drilling method. Finally, the residual stress distribution was superimposed to stress distribution because of fatigue loads obtained by FE analyses applying local concept, to calculate the stresses in the crack initiation zone and to understand the different types of failure that occurred in as‐welded and relieved specimens.
Involvement of portosystemic shunts in impaired improvement of liver function after direct‐acting antiviral therapies in cirrhotic patients with hepatitis C virus
Authors: Tsuji Shohei , Uchida Yoshihito , Uemura Hayato , Kouyama Jun‐Ichi , Naiki Kayoko , Nakao Masamitsu , Motoya Daisuke , Sugawara Kayoko , Nakayama Nobuaki , Imai Yukinori , Tomiya Tomoaki , Mochida Satoshi 
Published: December 2019

AimFactors responsible for impaired improvement of liver function despite sustained viral response after direct‐acting antiviral agents therapies in cirrhotic patients with hepatitis C virus need to be elucidated.MethodsLiver function and the extent of portosystemic shunting were evaluated for 79 patients with compensated cirrhosis, in whom sustained viral response had been achieved after direct‐acting antiviral agents therapies for hepatitis C virus at least 3 years earlier.ResultsPortosystemic shunts were observed in 63 patients (80%). Improvement and worsening, as compared with the baseline, of esophageal/gastric varices after direct‐acting antiviral agents therapies was seen in three patients (4%) and 10 patients (13%), respectively. Portal hypertension‐related events, such as varices and ascites requiring treatment, were observed in six patients (8%), in whom three patients showing worsening of Child–Pugh scores were included. Multivariate analysis showed that maximal diameter of the shunts (P = 0.012) and serum Mac‐2 binding protein glycosylation isomer levels at the end of treatment (P = 0.005) were associated with the development of portal hypertension‐related events, with cut‐off values of 5.25 mm (P = 0.001) and 6.84 cut‐off index (P < 0.001), respectively. The increase of serum albumin levels at 3 years, as compared with the baseline, was smaller in 22 patients having shunts with maximal diameters of ≥5 mm than in the remaining 57 patients (P = 0.034), whereas no such difference was seen between the patients with and without elevation of serum Mac‐2 binding protein glycosylation isomer level of ≥6.8 cut‐off index.ConclusionsA large size of portosystemic shunts was found to be a crucial determinant of impaired improvement of liver function, as well as of the development of portal hypertension‐related events, even after sustained viral response in patients with compensated cirrhosis.
Effect of different fibres on texture, rheological and sensory properties of acid casein processed cheese sauces
Authors: Szafrańska Jagoda O. , Sołowiej Bartosz G. 
Published: December 2019

SummaryThe objective of this study was the evaluation of different fibres (bamboo, acacia, potato or citrus) addition on texture, rheological and sensory properties of acid casein processed cheese sauces. Fibres used in production of sauces had an impact on the texture, viscosity, viscoelastic and sensory properties. The largest increase in viscosity was observed in products with addition of potato fibre, which have good water holding and adsorption capacity. Processed cheese sauce with the addition of citrus fibre was characterised by the highest values in general, and the increase of this feature in the tested samples was regular. Adhesiveness was the highest in products with 1% addition of every fibre. The lowest values of viscosity single shear,G′andG″moduli, among all tested, had sauces with acacia fibre. Moreover, they had the most thin liquid consistency, which was different from preferred one.
In vitro evaluation of the hyaluronic acid/alginate composite powder for topical haemostasis and wound healing
Authors: Chen Yi‐Wen , Lu Chia‐Hsin , Shen Meng‐Han , Lin Shih‐Yeh , Chen Chia‐Hui , Chuang Ching‐Kuang , Ho Chia‐Che 
Published: December 2019

AbstractThe use of haemostatic agents can provide life‐saving treatment for patients who suffer from massive bleeding in both prehospital and intraoperative conditions. However, there are still urgent demands for novel haemostatic materials that exhibit better haemostatic activity, biocompatibility, and biodegradability than existing products. In the present study, we aim to evaluate the feasibility of new wound dressing, RapidClot, for treating uncontrolled haemorrhage through a series of in vitro assessments to determine the swelling ratio, clotting time, enzymatic degradation, haemolytic activity, cytotoxicity, cell proliferation, and migration. The results indicated that the RapidClot revealed better water adsorption capacity and shorter blood clotting time (132.7 seconds) than two commercially available haemostatic agents Celox (378.7 seconds) and WoundSeal (705.3 seconds). Additionally, the RapidClot dressing exhibited a similar level of degradability in the presence of hyaluronidase and lysozyme as that of Celox, whereas negligible degradation of WoundSeal was obtained. Although both Celox and RapidClot revealed a similar level in cell viability (above than 90%) against NIH/3 T3 fibroblasts, improved cell proliferation and migration could be obtained in RapidClot. Taking together, our results demonstrated that RapidClot could possess a great potential for serving as an efficient healing dressing with haemorrhage control ability.
Rebuilding and guiding a care community: A grounded theory of end‐of‐life nursing care practice in long‐term care settings
Authors: Nasu Katsumi , Sato Kana , Fukahori Hiroki 
Published: December 2019

AbstractAimsTo investigate the end‐of‐life (EOL) nursing care practice process in long‐term care (LTC) settings for older adults in Japan.DesignA qualitative study based on grounded theory developed by Corbin and Strauss.MethodsSampling, interviewing, and analysis were performed cyclically, with results for each stage used as the basis for data collection and next‐stage analysis decisions. Semi‐structured interviews were conducted from March 2015‐March 2019 with 22 nurses from eight LTC settings. Analysis was performed using coding, constant comparison, and emerging categories.ResultsThe core category, “guiding the rebuilt care community to assist the dying resident” comprised five categories: “assessing the resident's stage,” “harmonizing care with the dying process,” “rebuilding a care community,“ “helping community members care for the resident,” and “encouraging community members to give meaning.” The participants were described as “traditional village elders“ who were the integral members of the care community, as well as guides who helped and encouraged the community.ConclusionResults revealed the holistic process of EOL nursing‐care practice in Japan. Nurses aimed to allow LTC residents to die as social human beings, surrounded by people, and not just responding physical and psychological distress. Such practice requires nursing expertise, healthcare skills, and leadership qualities to build and serve care communities. Nurses must also consider residents’ uncertainties and vulnerabilities as well as their cultural backgrounds.ImpactThis study showed that the nurses hold unique roles in providing dying people with care from a community. These findings can potentially be applied for developing a universal model for LTC nurses in many aging populations, to modify their EOL care practice, educate new LTC nurses, and collaborate with other healthcare professionals.
Curcumin has immunomodulatory effects on RANKL‐stimulated osteoclastogenesis in vitro and titanium nanoparticle‐induced bone loss in vivo
Authors: Yang Chao , Zhu Kechao , Yuan Xiangwei , Zhang Xianlong , Qian Yebin , Cheng Tao 
Published: December 2019

AbstractWear particle‐stimulated inflammatory bone destruction and the consequent aseptic loosening remain the primary causes of artificial prosthesis failure and revision. Previous studies have demonstrated that curcumin has a protective effect on bone disorders and inflammatory diseases and can ameliorate polymethylmethacrylate‐induced osteolysis in vivo. However, the effect on immunomodulation and the definitive mechanism by which curcumin reduces the receptor activators of nuclear factor‐kappa B ligand (RANKL)‐stimulated osteoclast formation and prevents the activation of osteoclastic signalling pathways are unclear. In this work, the immunomodulation effect and anti‐osteoclastogenesis capacities exerted by curcumin on titanium nanoparticle‐stimulated macrophage polarization and on RANKL‐mediated osteoclast activation and differentiation in osteoclastic precursor cells in vitro were investigated. As expected, curcumin inhibited RANKL‐stimulated osteoclast maturation and formation and had an immunomodulatory effect on macrophage polarization in vitro. Furthermore, studies aimed to identify the potential molecular and cellular mechanisms revealed that this protective effect of curcumin on osteoclastogenesis occurred through the amelioration of the activation of Akt/NF‐κB/NFATc1 pathways. Additionally, an in vivo mouse calvarial bone destruction model further confirmed that curcumin ameliorated the severity of titanium nanoparticle‐stimulated bone loss and destruction. Our results conclusively indicated that curcumin, a major biologic component of Curcuma longa with anti‐inflammatory and immunomodulatory properties, may serve as a potential therapeutic agent for osteoclastic diseases.
The probiotic, Leuconostoc mesenteroides, inhibits Listeria monocytogenes biofilm formation
Authors: Shao Xinhao , Fang Kuili , Medina Daniel , Wan Jason , Lee Jung‐Lim , Hong Seok Hoon 
Published: December 2019

AbstractListeria monocytogenes biofilm formation renders these cells highly resistant to current sanitation methods, and probiotics may be a promising approach to the efficient inhibition of Listeria biofilms. In the present study, three Leuconostoc mesenteroides strains of lactic acid bacteria isolated from kimchi were shown to be effective probiotics for inhibiting Listeria biofilm formation. Biofilms of two L. monocytogenes serotypes, 1/2a (ATCC15313) and 4b (ATCC19115), in dual‐species culture with each probiotic strain were decreased by more than 40‐fold as compared with single‐species Listeria biofilms; for instance, a reduction from 5.4 × 106 colony forming units (CFU)/cm2 L. monocytogenes ATCC19115 in single‐species biofilms to 1.1 × 105 CFU/cm2 in dual‐species biofilms. Most likely, one of the Leuconostoc strains, L. mesenteroides W51, led to the highest Listeria biofilm inhibition without affecting the growth of L. monocytogenes. The cell‐free supernatant from the L. mesenteroides W51 culture containing large protein molecules (>30 kDa) also inhibited Listeria biofilms. These data indicate that Leuconostoc probiotics can be used to repress L. monocytogenes biofilm contamination on surfaces at food processing facilities.
The safety of stopping nucleos(t)ide analogue treatment in patients with HBeAg‐negative chronic hepatitis B
Authors: Wong Grace L.‐H. , Chan Henry L.‐Y. , Yuen Becky W.‐Y. , Tse Yee‐Kit , Luk Hester W.‐S. , Yip Terry C.‐F. , Hui Vicki W.‐K. , Liang Lilian Y. , Lee Hye‐Won , Lui Grace C.‐Y. , Wong Vincent W.‐S. 
Published: December 2019

AbstractBackgroundThe rates of hepatitis B surface antigen (HBsAg) seroclearance after stopping nucleos(t)ide analogues (NA) in European (19% in 2 years) and Asian (13% in 6 years) patients with chronic hepatitis B (CHB) vary dramatically. We evaluated the incidence of hepatitis flare and HBsAg seroclearance in hepatitis B e antigen (HBeAg)‐negative Chinese CHB patients who had stopped NA.MethodsThis was a territory‐wide retrospective study in Hong Kong. We identified HBeAg‐negative CHB patients from January 2000 to December 2017 who had stopped NA treatment for more than 3 months. Hepatitis flare was defined as ALT >2×ULN.ResultsThe 1076 patients were predominantly middle‐aged men (mean age 52 years, male 74.8%) when starting NA; they stopped NA after 82 ± 35 months of treatment. At 44.3 ± 24.6 months after stopping NA, 147 (13.6%) patients had hepatitis flare, which led to resumption of NA; whereas 77 (7.2%) patients had flare but did not resume NA. Decompensation occurred in 7/914 (0.8%) patients. A total of 695 (64.6%) patients remained on NA treatment at the last visit. Eleven patients had achieved HBsAg seroclearance (6 of them had hepatitis flare and 1 of these 6 patients achieved HBsAg seroclearance after NA was restarted). Hepatic events developed in 75/695 (10.8%) patients who had NA resumed vs 43/381 (11.3%) patients who did not resume NA (P = .677).ConclusionsHepatitis flare and retreatment were common in HBeAg‐negative CHB patients who stopped NA treatment; whereas HBsAg seroclearance rarely occurred. Stopping NA to achieve functional cure should not be recommended at this moment.
Transfusion risk associated with recent arbovirus outbreaks in French Polynesia
Authors: Beau Frédéric , Mallet Henri‐Pierre , Lastère Stéphane , Broult Julien , Laperche Syria 
Published: December 2019

Background and objectivesFrench Polynesia, where dengue virus (DENV) has been present for a long time, experienced two successive outbreaks of Zika (ZIKV) and chikungunya viruses (CHIKV) between 2013 and 2015. To avoid the transmission of these viruses by transfusion, nucleic acid testing (NAT) has been in place for DENV since 2013 and for ZIKV and CHIKV during epidemics. The objective was to compare the estimated risk of viraemic blood donation with NAT results and to discuss the impact on the prevention of transfusion‐related infectious risk.Materials and methodsThe average risks of viraemic blood donation were estimated per year for DENV, and during the epidemic periods for ZIKV and CHIKV, using the Biggerstaff and Petersen model based on the incidence rate, the mean length of viraemia and the frequency of asymptomatic infection. The estimated risks were compared with the number of viraemic blood donations detected by NAT.ResultsAccording to the different assumptions, risks estimates ranged from 11·2 to 53·1/100 000 donations for DENV, 746 to 1924/100 000 for ZIKV and 1083 /100 000 for CHIKV. When compared to the number of donations collected during the study periods, these estimates match NAT results (5 blood donors reactive for DENV, 42 for ZIKV and 34 for CHIKV).ConclusionThe risks of viraemic blood donation were related to the viral incidence in the general population and concordant with NAT results. These findings suggest that the screening may be optimized by a targeted NAT implementation based on incidence data.
Resilience Decision-Making for Complex Systems
Authors: Salomon Julian , Broggi Matteo , Kruse Sebastian , Weber Stefan , Beer Michael 
Published: December 2019

Abstract
Complex systems—such as gas turbines, industrial plants, and infrastructure networks—are of paramount importance to modern societies. However, these systems are subject to various threats. Novel research does not only focus on monitoring and improving the robustness and reliability of systems but also focus on their recovery from adverse events. The concept of resilience encompasses these developments. Appropriate quantitative measures of resilience can support decision-makers seeking to improve or to design complex systems. In this paper, we develop comprehensive and widely adaptable instruments for resilience-based decision-making. Integrating an appropriate resilience metric together with a suitable systemic risk measure, we design numerically efficient tools aiding decision-makers in balancing different resilience-enhancing investments. The approach allows for a direct comparison between failure prevention arrangements and recovery improvement procedures, leading to optimal tradeoffs with respect to the resilience of a system. In addition, the method is capable of dealing with the monetary aspects involved in the decision-making process. Finally, a grid search algorithm for systemic risk measures significantly reduces the computational effort. In order to demonstrate its wide applicability, the suggested decision-making procedure is applied to a functional model of a multistage axial compressor, and to the U-Bahn and S-Bahn system of Germany's capital Berlin.