bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence Framework for Efficient Detection and Classification of Pneumonia Using Chest Radiography Images
Authors: Alqudah Ali Mohammad , Qazan Shoroq , Masad Ihssan S. 
Published: September 2020

Abstract
BackgroundChest diseases are serious health problems that threaten the lives of people. The early and accurate diagnosis of such diseases is very crucial in the success of their treatment and cure. Pneumonia is one of the most widely occurred chest diseases responsible for a high percentage of deaths especially among children. So, detection and classification of pneumonia using the non-invasive chest x-ray imaging would have a great advantage of reducing the mortality rates.ResultsThe results showed that the best input image size in this framework was 64 64 based on comparison between different sizes. Using CNN as a deep features extractor and utilizing the 10-fold methodology the propose artificial intelligence framework achieved an accuracy of 94% for SVM and 93.9% for KNN, a sensitivity of 93.33% for SVM and 93.19% for KNN and a specificity of 96.68% for SVM and 96.60% for KNN.ConclusionsIn this study, an artificial intelligence framework has been proposed for the detection and classification of pneumonia based on chest x-ray imaging with different sizes of input images. The proposed methodology used CNN for features extraction that were fed to two different types of classifiers, namely, SVM and KNN; in addition to the SoftMax classifier which is the default CNN classifier. The proposed CNN has been trained, validated, and tested using a large dataset of chest x-ray images contains in total 5852 images.
Factors Associated with the Use of Insecticide-Treated Nets: Analysis of the 2018 Burkina Faso Malaria Indicator Survey
Authors: Tassembedo Mahamadi , Coulibaly Soumaila , Ouedraogo Boukary 
Published: September 2020

Abstract
Sleep under an ITN reduce contact with mosquitoes through the combination of a physical barrier and an insecticidal effect, which reduces the incidence of malaria. The 2016–2020 Burkina Faso National Malaria Strategic Plan aims to have at least 90% of the population, 100% of children under age 5, and 100% of pregnant women sleep under an ITN. To help achieve this goal, this analysis examines the factors that are associated with the use of ITN nets by using data from the 2017-18 Burkina Faso Malaria Indicator Survey (MIS). The analysis examines individual, household, and community-level factors associated with ITN usage. According to the 2017-18 Burkina Faso MIS, 58% of individuals in households that own at least one ITN reported that they slept under an ITN on the night before the survey. The use of ITNs was significantly associated with individual, household, and community-level variables that included age, gender, age of household head, number of sleeping rooms, wealth, malaria prevalence, residence, and region. The results highlight areas of intervention at the individual, household, and community levels that can increase ITN use.
Isolation and Characterization of Cellulolytic Marine Bacteria for Litopenaeus Vannamei Aquaculture Using Sugarcane Bagasse as Carbon Source
Authors: Ren Wei , Xu Xueni , Long Hao , Zhang xiang , Cai Xiaoni , Huang Aiyou , Xie Zhenyu 
Published: September 2020

Abstract
Background: In aquaculture system, it is essential to adjust the inherent disadvantage of C/N ratio by adding a lot of additional carbon sources, such as sugarcane molasses, organic acids, and organic acid salts, which will greatly increase the cost of shrimp aquaculture. Herein, we aimed to isolate cellulolytic marine bacteria to hydrolyze sugarcane bagasse (SB) for reducing the cost of addition of external carbon sources in industrial Litopenaeus vannamei aquaculture.Results: A total of 97 cellulolytic marine bacterial strains belonged to 6 genera were isolated from 2,585 indigenous bacteria, indicating that seagrass bed can be used as an important place for screening the cellulolytic bacteria. The hydrolysis capacity (HC) of 58 cellulolytic marine bacterial strains was ranged from 1.1–4.0. MW-M5 displayed the largest HC value, followed by MW-M10 and MW-M14. The cellulase contents of 30 strains were more than 3 U/g in the supernatant of fermentation broth after 24 h, which was significantly higher than that of commercial cellulose. 26 cellulolytic marine bacteria with HC greater than 2 were safe for L. vannamei. MW-M19 with the lowest multiple antibiotic resistance index, 0.1, had a highest SB enzyme activity, 4.14 U/mL. The SB decomposition rates of CFW-C18 and MW-M15 were up to about 63.81% and 48.57% after fifteen days, respectively. Conclusions: These results provide valuable information for further construction of a shrimp aquaculture system based on low-cost external carbon sources using cellulolytic bacteria, and even for other biotechnological applications.
Impact of Culture Sensitivity Reports on the Pattern of Antibiotics use and Cost of Therapy: A Prospective Observational study
Authors: Altaf Ummara , Akhtar Muhammad Furqan , Ahmad Bashir , Yasir Hassan Mehmood , Godman Brian , Hashmi Furqan K , Saeed Hamid , Saleem Zikria 
Published: September 2020

Abstract
Background: There are concerns with inappropriate prescribing of antibiotics in hospitals especially broad spectrum in Pakistan and the subsequent impact on antimicrobial resistance rates. One recognized way to reduce inappropriate prescribing is for empirical therapy to be adjusted according to the result of culture sensitivity reports.Objective: To find the impact of culture sensitivity reports on the use of antibiotics and cost in a leading tertiary care hospital in Lahore.Methods: This prospective observational study was carried out in Ghurki trust teaching hospital. A total of 465 positive culture patients were taken over an 8 month study period using convenient sampling techniques and immediately sent to the microbiology laboratory for pathogen identification and susceptibility testing using the Kirby-Bauer disc diffusion method. Additional data was collected from the patient medical file which included demographic data, sample type, causative microbe, anti-microbial treatment given in empirical and definitive treatment as well as medicine costs. Results: Total of 497 isolates were detected from the 465 patient samples, which included 309 gram-negative rods and 188 gram-positive cocci. Out of 497 isolates, the most common Gram-positive pathogen isolated was MSSA (28.4%) and Gram-negative was E. coli (23.8%). Most of the gram-negative isolates were found to be resistant to ampicillin and co-amoxiclav. Most of the A. baumannii isolates were resistant to carbapenems. Gram-positive microorganism showed the maximum sensitivity to linezolid and vancomycin. The most widely used antibiotics in empirical therapy were cefoperazone+sulbactam, ceftriaxone, amikacin, vancomycin and metronidazole whereas high use of linezolid, clindamycin, meropenem and piperacillin + tazobactam was evidenced in definitive treatment. Empiric therapy was adjusted in 222 (71.8%) cases of Gram-negative infections and 131 (69.6%) cases of gram-positive infections (p-value <0.0001). Compared with empirical therapy, there was a 13.8% reduction in the number of antibiotics in definitive treatment. The average costs of antibiotics in definitive treatment was less than the empirical treatment (8.2%) and the length of hospitalization also decreased.Conclusion: Culture sensitivity reports helped reduce antibiotic utilization, hospital stay and costs as well as helping select the most appropriate treatment. We also found an urgent need for implementing antimicrobial stewardship programs and the development of hospital antibiotic guidelines within the hospital to reduce future unnecessary prescribing of broad-spectrum antibiotics.
Activities of Daily Living (ADL) Predicts in-hospital Mortality in Geriatric Patients with Community-acquired Pneumonia (CAP)
Authors: Kang Yu , Fang Xiang-Yang , wang dong , Wang Xiao-juan 
Published: September 2020

Abstract
Background: Community-acquired pneumonia (CAP) is an important problem with significant mortality. Activity of daily living (ADL) function decline is associated with increased mortality in elderly patients. We aimed to investigate the prognostic value of ADL at admission on the in-hospital mortality in geriatric patients with pneumonia. Methods: Patients over 65 years old admitted to Beijing Chao-yang hospital due to CAP from June 2012 through June 2020 were retrospectively reviewed by electronic medical records. Risk factors for mortality in pneumonia patients described in literature were included in our study. ADL evaluation at admission was performed by Barthel index (BI). Results: 4880 patients were included, 131 patients (2.7%) died during their admission. 69.5% patients in Dead group had a BI scores < 60. Mean BI score in the Dead group and Alive group were 49.89±30.20 and 81.57±22.14, respectively. Dead group had lower BI scores than Alive group (p＜0.001). A low BI was associated with increased in-hospital mortality. Logistic regression analyses demonstrated that ADL function at admission was significantly and independently associated with the in-hospital mortality, either in younger (age 65-74years) or very elderly (age≥75years) patients. Receiver operating characteristic ( ROC ) curve analysis revealed that BI at admission is an predictor related to in-hospital mortality in elderly patients, The area under the receiver operating characteristic (ROC) curves of BI in predicting in-hospital mortality was 0.81 (with 95% confidence interval: 0.78–0.85).Conclusion: ADL decline is associated with increased risk of in-hospital mortality among elderly patients hospitalized with CAP. ADL function at admission can predict in-hospital mortality in geriatric patients with CAP. Barthel Index (BI) can be used as a simple and convenient method for the assessment of the ADL functional status at admission in geriatric patients with CAP to identify patients at high risk and conducive to clinical decision making.
Chidamide Combined with Doxorubicin Induced p53-Driven Cell Cycle Arrest and Cell Apoptosis Reverse Multidrug Resistance of Breast Cancer
Authors: CAO Lixia , Zhao Shaorong , Yang Qianxi , Shi Zhendong , Liu Jingjing , Pan Teng , Zhou Dongdong , Zhang Jin 
Published: September 2020

Abstract
Background The multidrug-resistant (MDR) phenotype is usually accompanied by an abnormal expression of histone deacetylase (HDAC). Given that HDAC is vital in chromatin remodeling and epigenetics, inhibiting the role of HDAC has become an important approach for tumor treatment. However, the effect of HDAC inhibitors on MDR breast cancer has not been elucidated. This study aimed to evaluate the resistance of two MDR breast cancer cell lines to the HDAC-selective inhibitor chidamide (CHI). Methods Cell viability, cell cycle and apoptosis were detected by CCK8, crystal violet staining, EDU staining, TUNEL assay, flow cytometry. The expression of HDAC1, H3K9, H3K18, p53, p21, caspase3/7/9 and the Bcl family was analyzed by western blotting and Quantitative real-time PCR. MDR breast cancer growth suppression by CHI and/or doxorubicin (DOX) in vivo was investigated in a tumor xenograft mouse model. Results The results showed that, CHI combined with DOX showed significant cytotoxicity to MDR breast cancer cells in vitro and in vivo compared with the CHI monotherapy. The cell cycle distribution results showed that CHI caused G0/G1 cell cycle arrest and inhibited cell growth regardless of the addition of DOX. At the same time, Annexin V staining and TUNEL staining results showed that CHI enhanced the number of cell apoptosis in drug-resistant cells. The western blot analysis found that p53 as a tumor suppressor was in a silent state in drug-resistant cells. However, p53 was activated in the CHI-treated and combined treatment groups, which, in turn, activated the p53 up-regulated apoptosis regulator recombinant protein (Puma) and pro-apoptotic protein Bax, downregulated the apoptotic proteins Bcl-xL and Bcl-2, and activated the caspase cascade to induce apoptosis. Conclusion The irreversible cell stress induced by CHI combined with DOX reduced the expression of HDAC1 and activated caspase-dependent apoptosis and p21-mediated growth arrest pathway, which might have been driven by the activation of p53. This provided a strong theoretical basis for exploring the treatment strategy of the combined use of CHI in patients with breast cancer who did not respond to chemotherapy or had cancer progression.
Physician-Patient Communication in Decision-Making about Caesarean Sections in Eight District Hospitals in Bangladesh: A Mixed-Method Study
Authors: Doraiswamy Sathyanarayanan , Billah Sk Masum , Karim Farhana , Siraj Md. Shahjahan , Buckingham Alan , Kingdon Carol 
Published: September 2020

Abstract
Background: Caesarean sections (CS) in Bangladesh have risen eight-fold in the last 15 years. Few studies have explored why. Anecdotally, physicians suggest maternal request for CS is a reason. Women and families suggest physicians influence their decision-making. The aim of this research was to understand more about the decision-making process surrounding CS by exploring physician-patient communication leading to informed-consent for the operation. Methods: We conducted a mixed-method study using structured observations with the Option Grid Collaborative’s OPTION5 tool and interviews with physicians and women between July and December 2018. Study participants were recruited from eight district public-sector hospitals. Eligibility criteria for facilities was ≥80 births every month; and for physicians, was that they had performed CSs. Women aged ≥18 years, providing consent, and delivering at a facility were included in the observation component; primigravid women delivering by CS were selected for the in-depth interviews. Quantitative data from observations were analysed using descriptive statistics. Following transcription and translation, a preliminary coding framework was devised for the qualitative data analysis. We combined both inductive and deductive approaches in our thematic analysis. Results: In total, 306 labour situations were observed, and interviews were conducted with 16 physicians and 32 women who delivered by CS (16 emergency CS; 16 elective CS). In 92.5% of observations of physician-patient communication in the context of labour situations, the OPTION5 mean scores were low (5-25 out of 100) for presenting options, patient partnership, describing pros/cons, eliciting patient preferences and integrating patient preferences. Interviews found that non-clinical factors prime both physicians and patients in favour of CS prior to the clinical encounter in which the decision to perform a CS is documented. These interactions were both minimal in content and limited in purpose, with consent being an artefact of a process involving little communication.Conclusions: Insufficient communication between physicians and patients is one of many factors driving increasing rates of caesarean section in Bangladesh. While this single clinical encounter provides an opportunity for practice improvement, interventions are unlikley to impact rates of CS without simultaneoulsy addressing physician, patient and health system contextual factors too.
The Nexus of ‘Music, Mind, and Well-being’: Effects of Harmony in the Bush Music Intervention for Residents with Advanced Dementia in Australian Rural Nursing Homes
Authors: Hamiduzzaman Mohammad , Kuot Abraham , Greenhill Jennene , Strivens Edward , Parajuli Daya Ram , Isaac Vivian 
Published: September 2020

Abstract
BackgroundPersons with dementia often show aggression, depression, and anxiety and these symptoms and behaviours escalate overtime without treatment. Music has been found to be useful for managing these symptoms and behaviours and can significantly improve well-being. This paper reports the effect of music on residents with advanced dementia in rural nursing homes, as a key part of the Harmony in the Bush study.MethodsWe conducted a quasi-experimental research in five Australian rural nursing homes. Managers of nursing homes were contacted to select residents with advanced dementia, resulted in 74 residents who participated in person-centred music and culturally-appropriate group music sessions. Staff (104) and musicians (6) participated in 65 interviews and 20 focus groups. One-Way ANOVA and paired-samples t-test were performed to understand Music in Dementia Assessment Scale (MiDAS) scores. Qualitative data were thematically analysed.ResultsSeventy-four residents participated in an average of 9.5 [SD 4.73] person-centred music sessions and most of them were female (n = 52/70%). Analysis revealed the overall mean effect of the person-centred music at two-time points as 67% [during-70% {351.22 (SD:93.51)}; and after-63% {315.09 (SD:98.52)}]. The residents with (moderate to severe) pain, anxiety, sadness, and agitation at pre-intervention, presented an improvement in their levels of interest, response, initiation, involvement, and enjoyment at different time-points. The t-test showed that the MiDAS sub-categories’ mean scores differed significantly between the time-points: interest [t = 2.75, p = 0.001]; response [t = 2.94, p = 0.005]; initiation [t = 2.41, p = 0.019]; and involvement [t = 2.78, p = 0.007]. Additionally, the residents were observed at post-intervention with a reduction of agitation (87.5%), low in mood (87.5%), and anxiousness (70.3%); and an improvement in relaxation (75.5%), attentiveness (56.5%), and smiling (56.9%). Themes from qualitative data were behavioural change, meaningful interaction, being initiative, increased participation, and contentment.ConclusionFindings suggest the music intervention probably reduce the residents’ psychiatric symptoms and behaviours and improve well-being.Clinical RegistrationThe study is registered with the Australian and New Zealand Clinical. Trials Registry (ANZCTR) on 20/2/2018 (Registration No: ACTRN12618000263291p; http://www.ANZCTR.org.au/ACTRN12618000263291p.aspx).
Prevalence and Risk Factors for Nasal and Oropharyngeal Carriage of Staphylococcus Aureus in Insulin-Dependent Diabetics Individuals
Authors: Teixeira Nathalia Bibiana , Fortaleza Carlos Magno Castelo Branco , de Souza Matheus Cristovam , Pereira Thais Aline Monteiro , Colenci Bibiana Prada de Camargo , Cunha Maria de Lourdes Ribeiro de Souza da 
Published: September 2020

Abstract
Individuals with insulin-dependent diabetes are a risk group for infections caused by Staphylococcus aureus. The objective of this study was to determine the prevalence and risk factors for nasal and oropharyngeal carriage of S. aureus and MRSA in insulin-dependent diabetic individuals from Botucatu, São Paulo, Brazil. Additionally, susceptibility profiling, detection of the mecA gene, SCCmec typing and molecular typing by PFGE and MLST were performed in nasal and oropharyngeal swabs of 312 subjects. The prevalence of S. aureus and MRSA was 30.4% and 4.8%, respectively. SCCmec type IV was the predominant type among isolates, although some carried SCCmec types I and II. MRSA and MSSA clones were detected among the isolates of this population. In addition, an important clonal lineage (ST398) was identified among resistant and susceptible isolates. Age and lung disease were negatively associated with S. aureus carriage, while lower-extremity ulcers were a risk factor for S. aureus carriage. For MRSA, only male gender was a risk factor. These data suggest widespread dissemination of MRSA in the insulin-dependent diabetic population studied, as well as the emergence of important lineages among these individuals.
Electric Modulation of Conduction in MAPbBr3 Single Crystals
Authors: Ke Shanming , Luo Shangyu , Gong Jinhui , Qiu Liwen , Liang Renhong , Zhou Yangbo , Luo Bingcheng , Cheng Baochang , Wang Li , Shu Longlong 
Published: September 2020

Abstract
The resistive switching (RS) mechanism of hybrid organic-inorganic perovskites is an open question until now. Here, a switchable diode-like RS behavior in MAPbBr3 single crystals using Au (or Pt) symmetry electrodes is reported. Both the high resistance state (HRS) and low resistance state (LRS) are electrode-area dependent and light responsive. We propose an electric-field-driven inner p-n junction accompanied by an interface trap-controlled SCLC mechanism to explain this switchable diode-like RS behavior in MAPbBr3 single crystals.
Under nutrition and Associated Factors Among Adult People Attending Highly Active Anti-Retroviral Therapy in Health Facilities of Bench Maji Zone, South West Ethiopia, 2018.
Authors: Regassa Tilahun Mekonnen , Gudeta Tesfaye Abera 
Published: September 2020

Abstract
Background - Malnutrition is a condition in which a nutrition deficiency, excess or imbalance of energy, protein, and other nutrients causes adverse effects on tissue/body form. Nutritional issues are common in HIV disease. At some point, almost everyone living with HIV will face challenges in maintaining good nutrition. Objective - To assess under nutrition and associated factors among Adult Clients on Highly Active Antiretroviral Therapy in Health Facilities of Bench Maji Zone, South West Ethiopia,2018. Methods - Institutional based cross sectional study design with quantitative data collection was employed from May 01 – June 30/2018 . A total sample size was 1007 and the participants were selected by using consecutive sampling technique from selected health facilities. EpiData Statistical software version 3.1 and Statistical Package for Social Sciences (SPSS) software version 21.0 were used for data entry and analysis. Logistic regression analysis was used to identify factors associated to under nutrition in adults attending ART. Odds ratios with 95 % confidence intervals were used to examine associations between dependent & independent variables. P. value less than 0.05 was considered significant. Result: The magnitude of under nutrition among peoples on ART in this study was 154 (16.0%). In multivariable logistic regression analysis, factors contributing to under nutrition were identified; Age [AOR 2.4, 95% CI (1.1-5.4)], marital status[AOR 2.2, 95% CI (1.3-3.7)], occupational status[AOR 0.4,95% (0.2-0.9)], developing GI symptoms [AOR 2.6, 95% CI (1.5-4.5)] and WHO clinical stage [AOR 3.1, 95% CI (1.4-6.8)].were found to have statistically significant association with among peoples on ART. Conclusion: Significant numbers of peoples on ART drugs in the study area were under nutrition .Age, marital status, occupational status, WHO clinical stage of disease and developing gastro intestinal symptoms were identified factors of under nutrition among adult people on ART. The health care workers and experts work on the ART clinic should focuses on patient counseling about early prevention, detection and treatment of opportunistic infection, early health seeking behaviors before AIDs stage.