bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib‐Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency
Authors: Huang Jiali , Zhang Xiankang , Zhang Hui , Li Yu , Huang Huidan , Li Zhiyu , Qiu Zhixia , Wu Hongxi , Huang Dechun , Xu Xi , Bian Jinlei 
Published: December 2024

AbstractOvercoming acquired resistance to Osimertinib remains a critical challenge in treating NSCLC. This research indicates that Osimertinib‐resistant cells exhibit a strong dependence on glutamine metabolism. However, targeting GLS1 shows limited anticancer effects, probably because it cannot fully block the glutamine metabolic pathway. The investigation reveals that a more effective strategy involves simultaneously inhibiting both ASCT2 and GLS1. After confirming the efficacy of this dual‐targeting approach against Osimertinib‐resistant cells in preclinical models, the potential of utilizing a broad‐spectrum glutamine metabolism antagonist is further explored to achieve superior antitumor efficacy. DON, broad‐spectrum glutamine antagonist, presents toxicity issues. Herein, the high NQO1 expression in Osimertinib‐resistant NSCLC cells is leveraged to design an NQO1‐responsive DON prodrug, 10e (LBJ‐10e). This prodrug demonstrates superior safety compared to natural DON and greater antitumor activity against resistant tumors compared to the clinical phase II drug DRP104. These findings may address the clinical limitations of GLS1 allosteric inhibitors and underscore prodrug strategies in effectively treating Osimertinib‐resistant lung cancer, providing a foundation for future clinical trials.
Ca2+‐ and cGAMP‐Contained Semiconducting Polymer Nanomessengers for Radiodynamic‐Activated Calcium Overload and Immunotherapy
Authors: Cheng Danling , Luo Libai , Zhang Qin , Song Zheming , Zhan Yiduo , Tu Wenzhi , Li Jingchao , Ma Qiming , Zeng Xianchang 
Published: December 2024

AbstractVarious second messengers exert some vital actions in biological systems, including cancer therapy, but the therapeutic efficacy is often need to be improved. A semiconducting polymer nanomessenger (TCa/SPN/a) consisting of two second messengers, calcium ion (Ca2+) and cyclic guanosine monophosphate‐adenosine monophosphate (cGAMP) for metastatic breast cancer therapy, is reported here. Such a TCa/SPN/a is constructed to exhibit X‐ray response for the activatable delivery of mitochondria‐targeting Ca compound and cGAMP as stimulator of interferon genes (STING) agonist. With X‐ray irradiation, TCa/SPN/a could generate singlet oxygen (1O2) via radiodynamic effect for ablating solid tumors and improving the tumor immunogenicity by inducing immunogenic cell death (ICD). Furthermore, the released mitochondria‐targeting Ca compounds show a high binging effect on mitochondria and cause reactive oxygen species (ROS) generation and mitochondria damage via calcium overload, while cGAMP boosts immunological effect through activating STING pathway. In this way, TCa/SPN/a enables a radiodynamic‐activated calcium overload and immunotherapy to obviously inhibit the growths of bilateral tumors and also abolish tumor metastasis in metastatic breast cancer mouse models. This article should demonstrate the first smart dual‐functional nanotherapeutic containing two second messengers for precise and specific cancer therapy.
Susceptibility of Mitophagy‐Deficient Tumors to Ferroptosis Induction by Relieving the Suppression of Lipid Peroxidation
Authors: Liu Shan , Chen Jing‐Hong , Li Li‐Chao , Ye Zhi‐Peng , Liu Jian‐Nan , Chen Yu‐Hong , Hu Bing‐Xin , Tang Jia‐Hong , Feng Gong‐Kan , Li Zhi‐Ming , Deng Chu‐Xia , Deng Rong , Zhu Xiao‐Feng , Zhang Hai‐Liang 
Published: December 2024

AbstractThe identification of ferroptosis‐sensitive cancers is critical for the application of ferroptosis‐inducing therapies in cancer therapy. Here, patient‐derived organoid screening models of colorectal cancer are established to identify tumors that are sensitive to ferroptosis‐inducing therapy. This study discovers that patient‐derived tumors characterized by mitophagy deficiency are hypersensitive to ferroptosis‐inducing therapies. Mechanistically, a novel negative feedback regulatory pathway of lipid peroxidation is identified, which is one of the important intrinsic anti‐ferroptosis mechanisms of cancer cells. Lipid peroxidation‐mediated endoplasmic reticulum stress transcriptionally upregulates Parkin to promote mitophagy through ATF4. Mitophagy limits the generation of lipid peroxidation products and subsequently inhibits ferroptosis by inhibiting the accumulation of mitochondrial ROS. Mitophagy‐deficient tumors lack this anti‐ferroptotic mechanism, unleashing the generation of lipid peroxidation and potent ferroptotic cell death induced by erastin, RSL3, cysteine deprivation, radiotherapy, and immunotherapy. More importantly, ferroptosis‐inducing therapy selectively inhibits the growth and distant metastasis of mitophagy‐deficient tumors in vivo. In summary, patient‐derived organoids of colorectal cancer patients for screening ferroptosis‐sensitive tumors are established, providing a paradigm for identifying that patient‐derived tumors are sensitive to ferroptosis‐inducing therapies. This study concludes that mitophagy‐deficient tumors are vulnerable to ferroptosis induction, which may lead to the development of new therapeutic strategies for tumors deficient in mitophagy.
Organohydrogel Based Electronic Skin Reinforced by Dual‐Mode Conduction and Hierarchical Collagen Fibers Skeleton
Authors: Guo Ruyue , Bao Yan , Zheng Xi , Chen Jie , Zhang Wenbo , Liu Chao , Ma Jianzhong 
Published: December 2024

AbstractCollagen fiber skeleton from animal skin is an ideal substrate for electronic skin (e‐skin). However, the interface mismatch between conductive materials and skeleton and the monotonicity of conductive network still hinder its creation. Herein, a novel collagen fiber‐based e‐skin with dual‐mode conduction of NaCl and conductive spheres (IECS) is accomplished by loading organohydrogel into the skeleton via “permeation and self‐assembly”. The resulting interpenetrating network produces a 3D continuous, conductive pathway and strong interface interaction with high‐density hydrogen bonding, thus exhibiting excellent strength (24.5 MPa), conductivity (14.82 S m−1), sensing performance (sensitivity of 16.64), and environmental stability. The physical structure (3D skeleton, interpenetrating network) and chemical interaction (interface interaction, salting‐out) achieve energy dissipation. Meanwhile, the sensitivity is enhanced by dual‐mode conduction, conductive sphere array, and deformation amplification induced by collagen fibers. Additionally, the strong bonding ability between glycerin and collagen fibers with water molecules provides anti‐freezing and moisture‐retention characteristics. Thus, the strategic synergy of compositional and structural design makes IECS a promising force‐sensing part of piezoresistive sensor for human movement, pulse frequency, cipher transmission, and pressure distribution. In short, IECS presents a multifunctional platform for the invention of high‐performance e‐skin with on‐demand property, which offers great application potential in wearable electronics.
A Long‐Life Aqueous Rechargeable Aluminum‐Ammonium Hybrid Battery
Authors: Yuan Xinhai , Wang Tao , Zhong Jiang , Peng Bohao , Zhou Qi , Xiong Xiaosong , Li Chunyang , Liu Lili , Chen Yuhui , Fu Lijun , Zhu Jian , Wu Xiongwei , Wu Yuping , Duan Xiangfeng 
Published: December 2024

AbstractAqueous rechargeable batteries (ARBs) offer a low‐cost, high‐safety, and fast‐reacting alternatives for large‐scale energy storage. However, their further practical applications are limited by challenges in achieving satisfactory energy density, long cycling lifetime, and cost‐effectiveness. In this study, an aqueous rechargeable aluminum‐ammonium hybrid battery is reported (AAHB) that utilizes a Prussian blue analogue (K1.14FeIII[FeII(CN)6]·nH2O) as an ultra‐stable cathode for reversibly accommodating ammonium ion, paired with aluminum‐ one of the lowest‐cost metals, aside from iron—as the anode. An average working voltage of 1.15 V, remarkable rate capability, and an attractive energy density of 89.3 Wh kg−1 are achieved. Notably, the Prussian blue analogue cathode exhibits almost no attenuation after an ultra‐long cycle life of 100,000 cycles, and the assembled AAHB demonstrates a long cycling lifespan exceeding 10,000 cycles. This work opens a door for exploring high‐performance and low‐cost ARBs for grid‐level energy storage.
All‐Solid‐State Batteries with Extremely Low N/P Ratio Operating at Low Stack Pressure
Authors: Oh Jihoon , Kwon Dohun , Choi Seung Ho , Lee Nohjoon , Sohn Yeeun , Lee Taegeun , Lee Taeyong , Kim Ji Young , Bae Ki Yoon , Choi Jang Wook 
Published: December 2024

AbstractAll‐solid‐state batteries (ASSBs) are emerging as promising candidates for next‐generation energy storage systems. However, their practical implementation faces significant challenges, particularly their requirement for an impractically high stack pressure. This issue is especially critical in high‐energy density systems with limited negative‐to‐positive electrode capacity ratios (N/P ratios), where uneven lithium (Li) stripping induces the formation of interfacial voids. This study addresses these challenges by introducing an anode with a novel structural design that operates effectively under practically viable conditions while significantly reducing the N/P ratio to less than one. The approach entails the integration of a lithiophilic magnesium (Mg) film beneath a thin layer of the silicon‐graphite (SiGr) active materials. This structure facilitates the deposition of excess Li beneath the SiGr layer during overcharging, which enables stable cycling even at room temperature and at a low stack pressure of 3 MPa. By mitigating the poor contact that is characteristic of ASSBs with a low stack pressure, and simultaneously increasing the energy density by lowering the N/P ratio, the design significantly advances the key electrochemical properties of ASSBs.
Unlocking Potential Benefits on Applications of Probiotics in Inland Aquaculture Industry: A Review
Authors: Vulla Kelvin E. , Mmanda Francis P. , Nyangoko Baraka P. , Makule Edna E. 
Published: December 2024

ABSTRACTInland aquaculture operations are practised all over the world, contributing about 62.6% of all farmed aquatic animals. This venture is increasing worldwide and outpacing the global market demand for fish and fishery products driven by competition with other animals, over‐population and over‐exploitation of wild capture fisheries. These operations expand globally, associated with the degradation of the culture environment due to poor aquaculture management practices and algal blooms due to nutrient influxes as well as high demand of quality fish feeds of affordable price. To overcome these challenges, sustainable, healthy and environmentally friendly alternatives including probiotics application must be adopted to achieve better production, profitability and productivity as well as a resilient culture environment. In this review, information on potential applications of probiotics in aquaculture (inland aquaculture) focused on sources, safety, approved probiotics for aquaculture, characteristics of probiotics, mode of applications and its potential use on pathogenic microbes control, fish haematological parameters, growth performance and stress responses, water quality parameter, anti‐nutritional factors and feed digestibility, limitation of using probiotics in aquaculture and lastly future perspectives on the probiotics application in aquaculture industry were reviewed and compiled for future sustainable aquaculture production and productivity and environmentally friendly. The review has also highlighted all probiotics application and their approved authority for use in farmed freshwater fish (Nile tilapia Oreochromis niloticus, Catfish Clarias gariepinus, rainbow trout Oncorhynchus mykiss and common carp Cyprinus carpio) and their cultured environment worldwide. Therefore, the review has comprised all information on the potential benefits application of probiotics in an inland aquaculture for public documentation and also identifies gaps in the aquaculture industry that require further research and assessment.
Associations of arthritis with functional disability and depressive symptoms in general US adults: NHANES 1988–1994 and 1999–2018
Authors: Liu Xiaoting , Huang Yunzhen , Fu Jinjing , Mohedaner Mayila , Danzengzhuoga  , Yang Gan , Yang Zhenqing , Li Xueqin , Ma Xinye , Zhang Qiqi , Liu Zuyun , Wu Xifeng , Ying Zhimin 
Published: December 2024

AbstractObjectivesThis study aimed to examine the associations of arthritis with functional disability and depressive symptoms among general US adults. Additionally, it explored the relationship between radiographic knee osteoarthritis (assessed by X‐ray examination) and functional disability. Above findings seek to highlight the need for comprehensive physical and mental health management in individuals with arthritis.MethodsWe designed a cross‐sectional study utilizing multivariable logistic regression models to examine the associations. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were documented in a crude model and three adjusted models. Participants were from the National Health and Nutrition Examination Survey (NHANES) 1988–1994 and 1999–2018. Arthritis was self‐reported or graded by the Kellgren–Lawrence score after an objective X‐ray examination. Functional disability included disability in activities of daily living (ADL disability), instrumental activities of daily living (IADL disability), and mobility disability. Depressive symptom was assessed using the Patient Health Questionnaire (PHQ).ResultsWe included 22,566 older adults (≥60 years; 10,961 had self‐reported arthritis) for functional disability analysis (2377 older adults with data on X‐ray examination; 1012 had radiographic knee osteoarthritis) and 32,056 adults (≥20 years; 9175 had self‐reported arthritis) for depressive symptom analysis. After controlling for all covariates, self‐reported arthritis was associated with ADL disability (odds ratios [OR]: 2.677; 95% confidence interval [CI]: 2.499–2.868), IADL disability (OR: 2.064; 95% CI: 1.940–2.196), and mobility disability (OR: 2.954; 95% CI: 2.778–3.142), and depressive symptom (OR: 2.177; 95% CI: 1.979–2.395). In participants with data on X‐ray examination, radiographic knee osteoarthritis was only associated with mobility disability (OR: 1.437; 95% CI: 1.183–1.744).ConclusionsSelf‐reported arthritis was associated with ADL disability, IADL disability and mobility disability, and depressive symptoms. Among participants with X‐ray data, radiographic knee osteoarthritis was only associated with mobility disability in general US adults. Appropriate managements of both physical and mental health are needed for individuals with arthritis.
The Role of Coordination Mechanisms and Transaction Costs Promoting Sustainability Performance in Agri‐Food Supply Chains: Evidence From Ecuador
Authors: Moreno‐Miranda Carlos , Dries Liesbeth 
Published: December 2024

ABSTRACTSocial tensions and resource depletion pose significant challenges to the agri‐food sector, highlighting the need for coordinated strategies to ensure sustainability in supply chains. Despite its critical importance, the relationship between coordination mechanisms and sustainability performance remains underexplored. This study examines the interrelations between transactional characteristics, relational and formal coordination, and sustainability performance in agri‐food supply chains. By surveying 204 farmers and 135 downstream players across diverse supply chain arrangements, this research employs structural equation modeling and confirmatory factor analysis to analyze data suitability and test hypotheses. The empirical findings reveal nuanced relationships: relational governance has a significantly positive connection to economic and social sustainability within supply chains. There is also a positive, indirect relation between relational governance and ecological performance through the promotion of resource efficiency. Formal coordination practices facilitate strategic relationships and efficient resource allocation and as such connect to social and economic viability of supply chains. Transaction costs play a role as mediator between formal and relational coordination, and sustainability outcomes. Effective management of transaction costs can mitigate inefficiencies and foster collaborative efforts. By understanding these dynamics, policymakers and stakeholders can develop strategies to promote resilience and sustainability in global food systems.
A Review on Use of Electrolytes in Catalytic/ Sub‐Stoichiometric Amounts in Electro‐Organic Synthesis: A Much Greener Approach
Authors: Swaroop Toreshettahally R. , Suresh Rajaghatta N. , Umashankara Muddegowda , Rangappa Kanchugarakoppal S. 
Published: December 2024

AbstractIn this review, we have discussed the various types of organic electrochemical reactions which use catalytic/sub‐stoichiometric amount of inorganic and/or organic salts as electrolytes. We have also presented the plausible mechanism of each electro‐organic reaction. This review article highlights notable examples of electro‐organic synthesis published from 2000 to 2023.
Enhancing Quantum Entanglement Through Parametric Control of Atom‐Cavity States
Authors: Vesperini Arthur , Franzosi Roberto 
Published: December 2024

AbstractDicke states form a class of entangled states that has attracted much attention for their applications in various quantum algorithms. They emerge as eigenstates of the Tavis–Cummings (TC) Hamiltonian, a simplification of the Dicke model, which describes an assembly of two‐level atoms trapped in an electromagnetic cavity. In this letter, it is showed that in the regime where the field energy is large with respect to the atomic energy splitting, precise control of the ground state can be implemented. Specifically, pure Dicke states can be selected and produced by appropriate tuning of the parameters. This result may have important applications in quantum engineering and quantum information theory.
High‐Entropy Electrolytes with High Disordered Solvation Structures for Ultra‐Stable Zinc Metal Anodes
Authors: Wang Haoran , Deng Shenzhen , Wang Shuai , Li Wulong , Yuan Shixing , Han Jing , Fu Hongyan , Xu Bingang , Wei Lei 
Published: December 2024

AbstractAqueous zinc‐ion batteries (ZIBs) are playing an increasingly important role in the field of energy storage owing to their low cost, high safety, and environmental friendliness. However, their practical applications are still handicapped by severe dendrite formation and side reactions (e.g., hydrogen evolution reaction and corrosion) on the zinc anodes. Herein, a low‐concentration high‐entropy (HE) electrolyte strategy is proposed to achieve high reversibility and ultra‐durable zinc metal anode. Specifically, this HE electrolyte features multiple anions participating in coordination and highly disordered solvation shells, which would disrupt the intrinsic H‐bond network between water molecules and suppress interfacial side reactions. Moreover, these diversified weakly solvated structures can lower the solvation energy of Zn2+ solvation configurations and enhance zinc ion diffusion kinetics, thereby promoting uniform Zn deposition and electrode interface stability. Consequently, Zn||Zn symmetric cells exhibit over 2,000 hours of cycling stability, and Zn||Cu asymmetric cells achieve a high average Coulombic efficiency of 99.9 % over 500 cycles. Furthermore, the Zn||PANI full cell with the optimized HE‐50 mM electrolyte delivers a high specific capacity of 110.7 mAh g−1 over 2,000 cycles at 0.5 A g−1 and a capacity retention of 70.4 % at 15 A g−1 after 10,000 cycles. Remarkably, even at a low temperature of −20 °C, the Zn||PANI full cells equipped with HE‐50 mM electrolyte still demonstrate long‐term cycling stability over 600 cycles with a high‐capacity retention of 93.5 %. This research provides a promising strategy for the design of aqueous electrolytes, aiding in the development of low‐cost, high‐safety, and high‐performance aqueous batteries.
Lattice Modulation on Singlet‐Triplet Splitting of Silver Cluster Boosting Near‐Unity Photoluminescence Quantum Yield
Authors: Tian Wei‐Dong , Zhang Chengkai , Paul Sayan , Si Wei‐Dan , Wang Zhi , Sun Pan‐Pan , Anoop Anakuthil , Tung Chen‐Ho , Sun Di 
Published: December 2024

AbstractDeveloping thermally activated delayed fluorescence (TADF)‐active silver clusters with near‐unity quantum efficiency is of practical importance in cutting‐edge optoelectronic devices, but remains a tremendous challenge due to the difficulty of de novo synthesis and uncertainty of properties. Herein, we demonstrate a lattice modulation on parent TADF‐ active silver cluster, achieving TADF‐driven photoluminescence quantum yield (PLQY) from 12 % to near‐unity. Systematic experimental and calculated results reveal that the lattice modulation effectively lowers the singlet‐triplet splitting (ΔEST) from 718 to 549 cm‐1, thereby facilitating thermally activated reverse intersystem crossing: T5→S5, leading to extremely efficient TADF by surpassing both phosphorescence and non‐radiative decay, thus boosting the near‐unity PLQY. Such high PLQY is extremely rare in the TADF‐active silver clusters and even in the whole noble‐metal clusters. This research showcases an unparalleled example of lattice modulation to realize near unity PLQY of TADF‐active silver clusters.
Mass Transfer‐Enhanced Photothermal Membranes with Synergistic Light Utilization for High‐Turbidity Wastewater Purification
Authors: Fu Jiangchen , Xiao Shaoze , Cao Jiazhen , Liang Zhiyan , Chen Jiabin , Jiang Yue , Xing Mingyang 
Published: December 2024

AbstractThe photo‐Fenton process faces significant limitations in treating high‐turbidity, colored wastewater due to light attenuation and impurity interference (blocked mass transfer). To address these issues, we developed a suspended photothermal Fenton membrane by loading a photothermal catalyst on a hydrophobically modified cotton filter paper, enabling precise suspension 1 mm below the water surface. This design achieved 89.49 % light utilization and high chemical oxygen demand (COD) removal, even in wastewater with extreme chromaticity (10 multiples) and turbidity (703 NTU). The enhanced photothermal conversion accelerated molybdenum co‐catalyzed Fenton reactions and improved peroxymonosulfate (PMS) activation, maintaining over 90 % phenol removal for 15 days. Mechanistic simulations revealed improved mass transfer of reactive oxygen species (ROS) and pollutants at the solid–liquid interface, with PMS diffusion identified as the rate‐limiting step. The membrane resisted fouling from suspended solids and maintained stable operation in soil‐containing solutions for 10 days. This innovative approach offers an efficient solution for degrading pollutants in dark‐colored, high‐turbidity wastewater, overcoming traditional process limitations.
A Trithia‐Bridged N‐Heterotriangulene: The Hitherto Missing Electron Donor
Authors: Borstelmann Jan , Gensch Viktoria , Fehn Dominik , Miehlich Matthias E. , Hampel Frank , Rominger Frank , Meyer Karsten , Kivala Milan 
Published: December 2024

AbstractThe very first representative of trithia‐bridged N‐heterotriangulene, a triphenylamine with sulfur atoms bridging the ortho‐positions, was synthesized by a sequence of regioselective sulfenylation with phthalimidesulfenyl chloride followed by Lewis acid‐catalyzed electrophilic cyclization. X‐ray crystallography revealed a saddle‐shaped geometry of the polycyclic scaffold. UV/Vis absorption spectroscopy and cyclic voltammetry were used to characterize the optoelectronic properties. The title compound is a particularly strong electron donor forming a perfectly stable radical cation, which was analyzed by electron paramagnetic resonance spectroscopy and X‐ray crystallography. The electron donor properties were further highlighted by the formation of crystalline donor‐acceptor complexes with strong cyano‐based acceptors.