bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical supervision in older adult mental health services
Authors: Merizzi Alessandra 
Published: October 2019

Purpose
The purpose of this paper is to explore how supervision is applied in the context of National Health Service services for older adults, with particular regard to the profession of clinical psychology and psychotherapy.

Design/methodology/approach
The clinical supervision theories that are considered in this exploration are the Seven-Eyed Model (Hawkins and Shohet, 2012) and the Cyclical Model (Page and Wosket, 2015). The discussion also integrates an overview of psychological dynamics as presented by the existing literature with the author’s reflections on the influence of ageing stereotypes in the therapeutic work with older adults.

Findings
The theoretical models of clinical supervision considered can offer a robust framework and pathway for supervisory work in psychology and psychotherapy for older people. However, this alone seems insufficient and needs to be combined with the supervisor’s knowledge on psychology of ageing as well as their own self-reflection on internalised ageing stereotypes.

Practical implications
The paper suggests a need for health care professionals, providing clinical supervision on older adult therapeutic work, to be familiar with the aspects analysed.

Originality/value
Clinical supervision handbooks overlook aspects related to age as an issue of difference. This paper adds value to the clinical work with older people through a novel attempt to link implications of ageing stereotypes with the therapeutic and supervisory practice.
Ustekinumab treatment for hidradenitis suppurativa
Authors: Takeda Kana , Kikuchi Katsuko , Kanazawa Yoshitake , Yamasaki Kenshi , Aiba Setsuya 
Published: October 2019

AbstractHidradenitis suppurativa (HS) is a follicular occlusive inflammatory skin disease that occurs in the axilla, groin, buttocks and vulval region. Control of the intractable inflammation is a primary goal of HS treatments. Benefit of anti‐tumor necrosis factor (TNF) antibodies against HS have been reported, and adalimumab has been approved for HS in Europe, the USA and Japan. However, the alternative therapies for anti‐TNF antibodies have not been established yet. We experienced a case of HS which developed during the infliximab treatment for Crohn’s disease (CD) and was well managed by ustekinumab (UST). We reviewed the articles relating to ustekinumab treatments for HS. Twenty‐four HS patients, 16 women and eight men, have been treated with ustekinumab. The average age was 35.7 ± 10.8 years (mean ± SD). All were of Hurley stage II or III. Ten (10/24, 41.6%) had received anti‐TNF drugs including infliximab, adalimumab and etanercept prior to UST treatment for HS. Although the initial doses varied from 45 mg s.c. to 390 mg i.v., all cases were treated with 45 or 90 mg s.c. every 8 or 12 weeks at the regular dose, by following the regimen for psoriasis or CD. HS in most of the cases started to improve after 3–5 months of UST initiation, and some achieved complete remission. To our knowledge, our case is the first Asian HS patient improved by UST. Overall, UST is useful for HS and could be an alternative treatment if HS patients do not respond to other medications including anti‐TNF drugs.
Non‐canonical localization of RubisCO under high‐light conditions in the toxic cyanobacterium Microcystis aeruginosa PCC7806
Authors: Barchewitz Tino , Guljamow Arthur , Meissner Sven , Timm Stefan , Henneberg Manja , Baumann Otto , Hagemann Martin , Dittmann Elke 
Published: October 2019

SummaryThe frequent production of the hepatotoxin microcystin (MC) and its impact on the lifestyle of bloom‐forming cyanobacteria are poorly understood. Here, we report that MC interferes with the assembly and the subcellular localization of RubisCO, in Microcystis aeruginosa PCC7806. Immunofluorescence, electron microscopic and cellular fractionation studies revealed a pronounced heterogeneity in the subcellular localization of RubisCO. At high cell density, RubisCO particles are largely separate from carboxysomes in M. aeruginosa and relocate to the cytoplasmic membrane under high‐light conditions. We hypothesize that the binding of MC to RubisCO promotes its membrane association and enables an extreme versatility of the enzyme. Steady‐state levels of the RubisCO CO2 fixation product 3‐phosphoglycerate are significantly higher in the MC‐producing wild type. We also detected noticeable amounts of the RubisCO oxygenase reaction product secreted into the medium that may support the mutual interaction of M. aeruginosa with its heterotrophic microbial community.
Taxonomic review and distribution of giant water bugs (Hemiptera: Belostomatidae: Lethocerinae) in the Palearctic, Oriental, and Australian regions
Authors: Sareein Nattawut , Kang Ji Hyoun , Jung Sang Woo , Phalaraksh Chitchol , Bae Yeon Jae 
Published: October 2019

AbstractThe aim of the present study was to analyze the morphology and COI sequences of giant water bugs (Belostomatidae: Lethocerinae) that inhabit the Palearctic, Oriental, and Australian regions (i.e., three Lethocerus and a single Kirkaldyia species). Analysis revealed that both L. patruelis and L. indicus share two light stripes on the pronotum, but L. patruelis possesses narrower stripes and L. insulanus possesses an additional longitudinal narrow dark median band, whereas K. deyrolli was characterized by not having such markings. With regards to genetic analysis, the average intraspecific genetic distances of L. patruelis and L. indicus (from Palearctic and Oriental regions are 0.3 and 0.8%, respectively), but K. deyrolli which was collected from Northeast Asia, showed much higher intraspecific genetic distance (3.7%). The genetic distance between Kirkaldyia and Lethocerus (16.4–16.8%) is similar to that found between the genera of other hemipteran taxa. This study also newly reported the extended easternmost distribution of L. patruelis up to Surat Thani Province in southern Thailand. Along with K. deyrolli, which is considered threatened in South Korea and Japan, Lethocerus species have been facing threats in Southeast Asia, where they are heavily harvested and commonly sold in local markets as food. Therefore, future conservation efforts should be directed toward Lethocerus species in tropical Southeast Asia, especially the rarely found L. patruelis.
Accounting‐Based Compensation and Debt Contracts*
Authors: Li Zhi , Wang Lingling , Wruck Karen 
Published: October 2019

ABSTRACTWe examine how accounting‐based compensation plans influence a firm's contracts with its creditors. After granting long‐term accounting‐based compensation plans (LTAPs) to CEOs, firms pay lower spreads and have fewer restrictive covenants in new bank loans. Mechanisms leading to lower borrowing cost include improvements in debt repayment ability, reduced shareholder‐debtholder conflicts, and reduced risk‐taking incentives. Creditors view LTAPs as a substitute for monitoring, adjust covenant design based on LTAP features, and value plans with concave performance‐payout functions and reasonable performance targets. A firm's credit rating improves and CDS spread declines after LTAP grants, suggesting that LTAPs help reduce firms' credit risk.
Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction‐like phenotype in aged mice
Authors: Katsimpardi Lida , Kuperwasser Nicolas , Camus Claire , Moigneu Carine , Chiche Aurélie , Tolle Virginie , Li Han , Kokovay Erzsebet , Lledo Pierre‐Marie 
Published: October 2019

AbstractAging is a negative regulator of general homeostasis, tissue function, and regeneration. Changes in organismal energy levels and physiology, through systemic manipulations such as calorie restriction and young blood infusion, can regenerate tissue activity and increase lifespan in aged mice. However, whether these two systemic manipulations could be linked has never been investigated. Here, we report that systemic GDF11 triggers a calorie restriction‐like phenotype without affecting appetite or GDF15 levels in the blood, restores the insulin/IGF‐1 signaling pathway, and stimulates adiponectin secretion from white adipose tissue by direct action on adipocytes, while repairing neurogenesis in the aged brain. These findings suggest that GDF11 has a pleiotropic effect on an organismal level and that it could be a linking mechanism of rejuvenation between heterochronic parabiosis and calorie restriction. As such, GDF11 could be considered as an important therapeutic candidate for age‐related neurodegenerative and metabolic disorders.
Exploring patient attitudes to behaviour change before surgery to reduce peri‐operative risk: preferences for short‐ vs. long‐term behaviour change
Authors: McDonald S. , Yates D. , Durrand J. W. , Kothmann E. , Sniehotta F. F. , Habgood A. , Colling K. , Hollingsworth A. , Danjoux G. 
Published: October 2019

SummaryPre‐operative intervention to improve general health and readiness for surgery is known as prehabilitation. Modification of risk factors such as physical inactivity, smoking, hazardous alcohol consumption and an unhealthy weight can reduce the risk of peri‐operative morbidity and improve patient outcomes. Interventions may need to target multiple risk behaviours. The acceptability to patients is unclear. We explored motivation, confidence and priority for changing health behaviours before surgery for short‐term peri‐operative health benefits in comparison with long‐term general health benefits. A total of 299 participants at three UK hospital Trusts completed a structured questionnaire. We analysed participant baseline characteristics and risk behaviour profiles using independent sample t‐tests and odds ratios. Ratings of motivation, confidence and priority were analysed using paired sample t‐tests. We identified a substantial prevalence of risk behaviours in this surgical population, and clustering of multiple behaviours in 42.1% of participants. Levels of motivation, confidence and priority for increasing physical activity, weight management and reducing alcohol consumption were higher for peri‐operative vs. longer term benefits. There was no difference for smoking cessation, and participants reported lower confidence for achieving this compared with other behaviours. Participants were also more confident than motivated in reducing their alcohol consumption pre‐operatively. Overall, confidence ratings were lower than motivation levels in both the short‐ and long‐term. This study identifies both substantial patient desire to modify behaviours for peri‐operative benefit and the need for structured pre‐operative support. These results provide objective evidence in support of a ‘pre‐operative teachable moment’, and of patients’ desire to change behaviours for health benefits in the short term.
Stopping anti‐tumour necrosis factor therapy in patients with perianal Crohn’s disease
Authors: Mak Joyce Wing Yan , Tang Whitney , Yip Terry Cheuk Fung , Ran Zhi Hua , Wei Shu Chen , Ahuja Vineet , Kumar Sudheer , Leung Wai Keung , Hilmi Ida , Limsrivilai Julajak , Aniwan Satimai , Lam Belsy C. Y. , Chan Kam Hon , Ng Ka Man , Leung Chi Man , Li Michael K. K. , Lo Fu Hang , Sze Alex Shun Fung , Tsang Steven Woon Choy , Hui Aric J. , Hartono Juanda Leo , Ng Siew C. 
Published: October 2019

SummaryBackgroundLittle is known of the outcome of patients with perianal Crohn's disease after stopping anti‐tumour necrosis factor (TNF) therapy.AimTo evaluate the rate of relapse in perianal Crohn's disease (CD) after stopping anti‐TNF therapy.MethodsConsecutive perianal CD patients treated with anti‐TNF therapy with subsequent discontinuation were retrieved from prospective inflammatory bowel disease database of institutes in Hong Kong, Shanghai, Taiwan, Malaysia, Thailand and Singapore from 1997 to June 2019. Cumulative probability of perianal CD relapse was estimated using Kaplan‐Meier method.ResultsAfter a median follow‐up of 89 months (interquartile range [IQR]: 65‐173 months), 44 of the 78 perianal CD patients (56.4%) relapsed after stopping anti‐TNF, defined as increased fistula drainage or recurrence of previously healed fistula, after stopping anti‐TNF therapy. Cumulative probabilities of perianal CD relapse were 50.8%, 72.6% and 78.0% at 12, 36 and 60 months, respectively. Younger age at diagnosis of CD [adjusted hazard ratio (HR): 1.04; 95% CI 1.01‐1.09; P = .04] was associated with a higher chance of perianal CD relapse. Among those with perianal CD relapse (n = 44), retreatment with anti‐TNF induced remission in 24 of 29 patients (82.8%). Twelve (27.3%) patients required defunctioning surgery and one (2.3%) required proctectomy. Maintenance with thiopurine was not associated with a reduced likelihood of relapse [HR = 1.10; 95% CI: 0.58‐2.12; P = .77]. Among the 17 patients who achieved radiological remission of perianal CD, five (35.3%) developed relapse after stopping anti‐TNF therapy after a median of 6 months.ConclusionsMore than half of the perianal CD patients developed relapse after stopping anti‐TNF therapy. Most regained response after resuming anti‐TNF. However, more than one‐fourth of the perianal CD patients with relapse required defunctioning surgery. Radiological assessment before stopping anti‐TNF is crucial in perianal CD.
Trends in urethral stricture management over two decades
Authors: McGeorge Stephen , Chung Amanda , Desai Devang J. 
Published: October 2019

ObjectivesTo identify trends in the management of urethral stricture disease in Australia, assess changes in the standard of care, and examine the availability of genitourinary reconstructive surgery.MethodsData on eight stricture management procedures were collected online via Medicare Item Reports from the Australian Government Department of Human Services, and then matched to population data from the Australian Bureau of Statistics. A survey was disseminated via the Urological Society of Australia and New Zealand (USANZ) asking whether active members performed urethroplasty and whether this was done in a rural, regional or metropolitan setting.ResultsOver a 22‐year period, there were 140 540 endoscopic procedures and 5136 urethroplasties, with 27.4 endoscopic procedures per urethroplasty. From 1994 to 2016, the per capita number of passage of sounds and dilatation procedures decreased by 74% and 75%, respectively, with increases in use of optical urethrotomy of 70% and in single‐stage urethroplasty of 144%. Overall, the ratio of all endoscopic procedures vs urethroplasty decreased from 58.9 to 16.8. There were as few as 16 surgeons in the USANZ performing urethroplasty, with seven providing this service in regional areas. Seven had formal fellowship training.ConclusionThere has been a clear shift from repetitive endoscopic procedures towards urethroplasty, but the former still make up the majority of interventions. This may be explained by patients not being referred for urethroplasty earlier in the course of disease and there appears to be a gap in genitourinary reconstructive expertise in regional and rural areas.
Activation of oestrogen receptor α induces a novel form of LTP at hippocampal temporoammonic‐CA1 synapses
Authors: Clements Leigh , Harvey Jenni 
Published: October 2019

Background and Purpose17β estradiol (E2) rapidly regulates excitatory synaptic transmission at the classical Schaffer collateral (SC) input to hippocampal CA1 neurons. However, the impact of E2 on excitatory synaptic transmission at the distinct temporoammonic (TA) input to CA1 neurons and the oestrogen receptors involved is less clear.Experimental ApproachExtracellular recordings were used to monitor excitatory synaptic transmission in hippocampal slices from juvenile male (P11‐24) Sprague Dawley rats. Immunocytochemistry combined with confocal microscopy was used to monitor the surface expression of the AMPA receptor (AMPAR) subunit, GluA1 in hippocampal neurons cultured from neonatal (P0‐3) rats.Key ResultsHere, we show that E2 induces a novel form of LTP at TA‐CA1 synapses, an effect mirrored by the ERα agonist, PPT, and blocked by an ERα antagonist. ERα‐induced LTP is NMDA receptor (NMDAR)‐dependent and involves a postsynaptic expression mechanism that requires PI 3‐kinase signalling and synaptic insertion of GluA2‐lacking AMPARs. ERα‐induced LTP has overlapping expression mechanisms with classical Hebbian LTP, as HFS‐induced LTP occluded PPT‐induced LTP and vice versa. In addition, activity‐dependent LTP was blocked by the ERα antagonist, suggesting that ERα activation is involved in NMDA‐LTP at TA‐CA1 synapses.Conclusion and ImplicationsERα induces a novel form of LTP at juvenile male hippocampal TA‐CA1 synapses. As TA‐CA1 synapses are implicated in episodic memory processes and are an early target for neurodegeneration, these findings have important implications for the role of oestrogens in CNS health and neurodegenerative disease.
Life‐Cycle Approach to Environmental Innovation: Cost Structure, Advertising, and Competition
Authors: Yenipazarli Arda , Vakharia Asoo , Bala Ram 
Published: October 2019

ABSTRACTUsing life‐cycle assessment–based methods, products can be differentiated by the environmental performance/impact during their manufacturing and use life‐cycle stages. Some products are reported to have higher environmental impact during the use stage, whereas for others, the environmental impact turns out to be higher during the manufacturing stage. In this article, we focus on those products in the former category, and consider a duopoly setting where profit‐maximizing firms decide on their use‐stage environmental innovation efforts, advertising efforts to disclose information on the manufacturing‐stage environmental performance of their products, and production quantities. Use‐stage environmental innovation not only improves the environmental performance of the product in use, but also increases the value of the product to end‐consumers (e.g., through cost‐of‐use reduction). We examine two distinct cases where such innovation can be achieved through either an up‐front capital investment or an increase in variable cost of production. Manufacturing‐stage environmental performance of a product is typically not visible to end‐consumers but could be communicated through advertising efforts. Two well‐recognized advertising strategies—namely, combative advertising and constructive advertising—are analyzed as alternative information disclosure strategies. We show that when only symmetric strategies are followed by competing firms (i.e., when each firm matches its competitor's advertising approach), firms should always employ constructive advertising strategy to disclose information on the manufacturing‐stage environmental performance of their products, and this result holds regardless of the environmental innovation cost structure. When asymmetric strategies are also an option, for marginal cost‐intensive innovations, the equilibrium can be characterized by asymmetric advertising strategy choices of symmetric firms, whereas for development cost‐intensive innovations, it is always characterized by symmetric advertising strategy choices. In this context, we advance understanding on when use‐stage environmental innovation and manufacturing‐stage environmental performance disclosure decisions can be the most effective economically to competing firms and examine their corresponding environmental consequences.
Impact of duration of untreated psychosis in short‐term response to treatment and outcome in antipsychotic naïve first‐episode psychosis
Authors: Cavalcante Daniel A. , Coutinho Luccas S. , Ortiz Bruno B. , Noto Mariane N. , Cordeiro Quirino , Ota Vanessa K. , Belangeiro Sintia I. , Bressan Rodrigo A. , Gadelha Ary , Noto Cristiano 
Published: October 2019

AbstractAimDuration of untreated psychosis (DUP) is one of the few potentially modifiable outcome predictors in psychosis. Previous studies have associated a longer DUP with a poor prognosis, but few of them were performed in countries with low and middle level of income. This study aimed to investigate the DUP in a Brazilian sample of antipsychotic‐naïve first‐episode psychosis (AN‐FEP) patients and its association with clinical characteristics and treatment outcomes in a short‐term follow‐up.MethodsOne hundred forty‐five AN‐FEP patients between 16 and 40 years were enrolled and were reassessed 10 weeks after risperidone treatment. We investigated the association between DUP and symptom severity, functionality and response to treatment, using the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression—Severity Scale (CGI) and the Global Assessment of Functionality (GAF) scale. DUP was defined as the period between the onset of the first psychotic symptoms and the first effective antipsychotic treatment. For the analysis, we performed multivariate linear regressions.ResultsThe DUP's median was 61 days. At baseline, we did not find any significant association between DUP and clinical characteristics. After treatment, the longer DUP predicted worse positive and negative symptom dimensions, worse total PANSS, GAF and CGI scores and poorer response to treatment.ConclusionOur results showed that DUP is associated with worse outcomes after short treatment, but it does not modify the baseline clinical profile of the AN‐FEP patients. Such results reinforce the need to develop early intervention strategies, reducing DUP.
No consistent effects of humans on animal genetic diversity worldwide
Authors: Millette Katie L. , Fugère Vincent , Debyser Chloé , Greiner Ariel , Chain Frédéric J. J. , Gonzalez Andrew 
Published: October 2019

AbstractHuman impacts on genetic diversity are poorly understood yet critical to biodiversity conservation. We used 175 247 COI sequences collected between 1980 and 2016 to assess the global effects of land use and human density on the intraspecific genetic diversity of 17 082 species of birds, fishes, insects and mammals. Human impacts on mtDNA diversity were taxon and scale‐dependent, and were generally weak or non‐significant. Spatial analyses identified weak latitudinal diversity gradients as well as negative effects of human density on insect diversity, and negative effects of intensive land use on fish diversity. The observed effects were predominantly associated with species turnover. Time series analyses found nearly an equal number of positive and negative temporal trends in diversity, resulting in no net monotonic trend in diversity over this time period. Our analyses reveal critical data and theory gaps and call for increased efforts to monitor global genetic diversity.
Fungal infection alters the selection, dispersal and drift processes structuring the amphibian skin microbiome
Authors: Wilber Mark Q. , Jani Andrea J. , Mihaljevic Joseph R. , Briggs Cheryl J. 
Published: October 2019

AbstractSymbiotic microbial communities are important for host health, but the processes shaping these communities are poorly understood. Understanding how community assembly processes jointly affect microbial community composition is limited because inflexible community models rely on rejecting dispersal and drift before considering selection. We developed a flexible community assembly model based on neutral theory to ask: How do dispersal, drift and selection concurrently affect the microbiome across environmental gradients? We applied this approach to examine how a fungal pathogen affected the assembly processes structuring the amphibian skin microbiome. We found that the rejection of neutrality for the amphibian microbiome across a fungal gradient was not strictly due to selection processes, but was also a result of species‐specific changes in dispersal and drift. Our modelling framework brings the qualitative recognition that niche and neutral processes jointly structure microbiomes into quantitative focus, allowing for improved predictions of microbial community turnover across environmental gradients.