bluuebunny/crossref_metadata_2025_split huggingface dataset:
واقع التخطيط الاستراتيجي بكليات جامعة مصراتة- كلية التربية نموذجاً
Authors: عبدالسلام زهرة الشريف , بن إسماعيل غادة جمال 
Published: October 2019

هدف البحث الحالي إلى التعرف على (واقع التخطيط الاستراتيجي بكليات جامعة مصراته- كلية التربية نموذجاً) ولتحقيق هذا الهدف تم طرح التساؤل الرئيسي الآتي:
- ما واقع التخطيط الاستراتيجي بكليات جامعة مصراتة – كلية التربية نموذجاً؟ ويتفرع منه التساؤلات الفرعية الآتية:
1- ما مستوى انتشار ثقافة التخطيط الاستراتيجي في الكلية ؟
2- ما مستوى ممارسة إدارة الكلية للتخطيط الاستراتيجي ؟
3- ما مستوى كفاءة الموارد البشرية في عملية التخطيط الاستراتيجي ؟
4- ما مدى توافر الموارد المالية في الكلية لخدمة عملية التخطيط الاستراتيجي ؟
5- هل توجد فروق ذات دلالة إحصائية في استجابات أفراد العينة لواقع التخطيط الاستراتيجي وفقاً لمتغيرات الجنس، وسنوات الخبرة؟
ولتحقيق أهداف البحث اعتمدت الباحثتان على المنهج الوصفي التحليلي، وتم الاعتماد على الاستبانة المعدّة مسبقاً في دراسة (الشويخ، 2007) بعد إجراء بعض التعديلات عليها حيث تكونت من (34) فقرة ضمن أربعة مجالات، وتم توزيعها على عدد (16) من رؤساء الأقسام العلمية، وتم معالجة البيانات باستخدام برنامج التحليل الإحصائي"SPSS".وقد توصل البحث إلى النتائج الآتية:

1-	أن مستوى انتشار ثقافة التخطيط الاستراتيجي لدى أفراد العينة جاء بنسبه متوسطة.
2-	أن مستوى ممارسة التخطيط الاستراتيجي لدى أفراد العينة جاء بنسبه متوسطة.
3-	أن مستوى كفاءة الموارد البشرية لدى أفراد العينة جاء بنسبه متوسطة.
4-	أن توافر الموارد المالية في الكلية لخدمة عملية التخطيط الاستراتيجي جاءت بنسبة منخفضة.
5-	عدم وجود فروق ذات دلالة إحصائية في استجابات أفراد العينة حول واقع التخطيط الاستراتيجي وفقاً لمتغيرات الجنس, سنوات الخبرة.
الكلمات المفتاحية: التخطيط – التخطيط الاستراتيجي – جامعة مصراتة
Semen exosomes inhibit HIV infection and HIV‐induced proinflammatory cytokine production independent of the activation state of primary lymphocytes
Authors: Welch Jennifer L. , Kaufman Thomas M. , Stapleton Jack T. , Okeoma Chioma M. 
Published: October 2019

Semen exosomes (SE) inhibit HIV infection. However, the effect of SE on cell activation and inflammation remains unknown. We characterized the response of peripheral blood mononuclear cells (PBMCs) from HIV‐uninfected and antiretroviral therapy‐suppressed HIV‐infected (HIV+) subjects to SE. Quiescent PBMCs or T‐cell receptor (TCR)‐activated PBMCs from HIV− and HIV+ donors were stimulated with SE in the presence/absence of ex vivo HIV infection. In HIV‐infected PBMCs, SE did not reactivate HIV, did not induce lymphoblast development, nor increase CD69+/CD25+ numbers. Furthermore, SE inhibited de novo HIV infection without altering cell activation. SE also asynchronously downregulated HIV‐inducible IL1β, IL8, and TNFα and upregulated CXCL10. These data suggest that SE inhibits HIV infection and production of HIV‐induced proinflammatory cytokines while preserving lymphocyte activation.
A Redox‐Triggered Bispecific Supramolecular Nanomedicine Based on Peptide Self‐Assembly for High‐Efficacy and Low‐Toxic Cancer Therapy
Authors: Yang Da‐Song , Yang Yin‐He , Zhou Yunjiang , Yu Li‐Li , Wang Rui‐Han , Di Bin , Niu Miao‐Miao 
Published: October 2019

AbstractPolo‐like kinase 1 (PLK1) and polo‐like kinase 4 (PLK4) are closely associated with the progression of several cancers, and their bispecific inhibitors can kill tumor cells effectively. Herein, a redox‐responsive bispecific supramolecular nanomedicine based on the self‐assembly of a cyclic peptide, termed as C‐1, targeting both PLK1 and PLK4 as a potent anticancer agent is reported. C‐1 is a cyclic peptide in response to reducing agents such as glutathione (GSH), which is constructed by a combined approach of pharmacophore modeling, molecular docking, and reversible cyclization. After entering the cytosol of cancer cell, the disulfide linkage is reduced by intracellular GSH, with the resulting linear conformation self‐assembling into bispecific nanofibers. C‐1 can lead to apoptotic cell death by inducing caspase‐3 activation and PARP cleavage in HeLa cells. Moreover, it suppresses the growth of HeLa cells in cell assays, and inhibits the progression of HeLa cells‐induced xenografts in nude mice without inducing notable side effects. This work provides a successful example of developing the redox‐responsive bispecific nanomedicine for high‐efficacy and low‐toxic cancer therapy.
Metal Boride‐Based Catalysts for Electrochemical Water‐Splitting: A Review
Authors: Gupta Suraj , Patel Maulik K. , Miotello Antonio , Patel Nainesh 
Published: October 2019

AbstractElectrocatalytic water‐splitting has gained a firm hold in the area of renewable hydrogen production owing to its integrative compatibility with intermittent energy sources. However, wide‐scale implementation of this technology demands discovery of new electrode materials that strike a good balance between efficiency, stability, and cost. In the pool of inexpensive electrodes capable of catalyzing hydrogen and oxygen evolution reactions, metal borides/borates have made a big splash in the last decade. However, the research in this family of electrocatalysts remains unorganized owing to the diversity of reports. This review summarizes the past and present research progress in metal borides/borates for electrocatalytic water‐splitting. The fundamental reasons for electrochemical behavior in different metal borides/borates are highlighted here, also including some comments regarding erroneous practices in the performance evaluation of metal borides/borates. Various strategies used to enhance the electrocatalytic performance of metal borides/borates are discussed in detail. Different methods evolved over the years for the synthesis of metal borides/borates are also discussed. Finally, an assessment of the commercial viability of metal borides/borates is made and future research directions are suggested.
3D Printed Microheater Sensor‐Integrated, Drug‐Encapsulated Microneedle Patch System for Pain Management
Authors: Yin Mengtian , Xiao Li , Liu Qingchang , Kwon Sung‐Yun , Zhang Yi , Sharma Poonam R. , Jin Li , Li Xudong , Xu Baoxing 
Published: October 2019

AbstractMicroneedle patch devices have been widely utilized for transdermal drug delivery in pain management, but is challenged by accurate control of drug release and subsequent diffusion to human body. The recent emerging wearable electronics that could be integrated with microneedle devices offer a facile approach to address such a challenge. Here a 3D‐printed microheater integrated drug‐encapsulated microneedle patch system for drug delivery is presented. The ink solution comprised polydimethylsiloxane (PDMS) and multiwalled carbon nanotubes (MWCNTs) with a mass concentration of up to 45% (≈10 times higher of existing ones) is prepared and used to print crack‐free stretchable microheaters on substrates with a broad range of materials and geometric curves. The adhesion strength of the printed microheater on the microneedle patch in elevated temperatures is measured to evaluate their integration performance. Assessments of encapsulated drug release into rat's skin are confirmed by examining degradation of microneedles, skin morphologies, and released fluorescent signals. Results and demonstrations established here creates a new opportunity for developing sensor controlled smart microneedle patch systems by integrating with wearable electronics, potentially useful in clinical and biomedical research.
CRISPR/Cas13a‐Powered Electrochemical Microfluidic Biosensor for Nucleic Acid Amplification‐Free miRNA Diagnostics
Authors: Bruch Richard , Baaske Julia , Chatelle Claire , Meirich Mailin , Madlener Sibylle , Weber Wilfried , Dincer Can , Urban Gerald Anton 
Published: October 2019

AbstractNoncoding small RNAs, such as microRNAs, are becoming the biomarkers of choice for multiple diseases in clinical diagnostics. A dysregulation of these microRNAs can be associated with many different diseases, such as cancer, dementia, and cardiovascular conditions. The key for effective treatment is an accurate initial diagnosis at an early stage, improving the patient's survival chances. In this work, the first clustered regularly interspaced short palindromic repeats (CRISPR)/Cas13a‐powered microfluidic, integrated electrochemical biosensor for the on‐site detection of microRNAs is introduced. Through this unique combination, the quantification of the potential tumor markers microRNA miR‐19b and miR‐20a is realized without any nucleic acid amplification. With a readout time of 9 min and an overall process time of less than 4 h, a limit of detection of 10 pm is achieved, using a measuring volume of less than 0.6 µL. Furthermore, the feasibility of the biosensor platform to detect miR‐19b in serum samples of children, suffering from brain cancer, is demonstrated. The validation of the obtained results with a standard quantitative real‐time polymerase chain reaction method shows the ability of the electrochemical CRISPR‐powered system to be a low‐cost, easily scalable, and target amplification‐free tool for nucleic acid based diagnostics.
3D Printable and Reconfigurable Liquid Crystal Elastomers with Light‐Induced Shape Memory via Dynamic Bond Exchange
Authors: Davidson Emily C. , Kotikian Arda , Li Shucong , Aizenberg Joanna , Lewis Jennifer A. 
Published: October 2019

Abstract3D printable and reconfigurable liquid crystal elastomers (LCEs) that reversibly shape‐morph when cycled above and below their nematic‐to‐isotropic transition temperature (TNI) are created, whose actuated shape can be locked‐in via high‐temperature UV exposure. By synthesizing LCE‐based inks with light‐triggerable dynamic bonds, printing can be harnessed to locally program their director alignment and UV light can be used to enable controlled network reconfiguration without requiring an imposed mechanical field. Using this integrated approach, 3D LCEs are constructed in both monolithic and heterogenous layouts that exhibit complex shape changes, and whose transformed shapes could be locked‐in on demand.
CV‐driven Optimization: Cobalt‐Catalyzed Electrochemical Expedient Oxychlorination of Alkenes via ORR
Authors: Tian Siyu , Lv Shide , Jia Xiaofei , Ma Li , Li Baoying , Zhang Guofeng , Gao Wei , Wei Yingqin , Chen Jianbin 
Published: October 2019

AbstractInstead of screening reaction conditions by yield‐based chemical trial‐and‐error, potential‐based cyclic voltammetry was alternatively employed for optimization of electrochemical oxychlorination of alkenes. With this unconventional screening method, the catalyst system including catalysts, molar ratio of chloride sources and solvents were identified in a rational, time‐ and energy‐efficient manner. The optimal catalytic system in combination with oxygen reduction reaction enabled broad substrate scopes for the desired transformation by taking advantages of persistent radical effect. UV‐vis and CV titration experiments confirmed the in‐situ formed catalytic species [CoCl5]. Moreover, cyclic voltammetry was applied to obtain mechanistic insights in our reaction system.magnified image
Composite Thermoresponsive Hydrogel with Auranofin‐Loaded Nanoparticles for Topical Treatment of Vaginal Trichomonad Infection
Authors: Zhang Yue , Miyamoto Yukiko , Ihara Sozaburo , Yang Justin Z. , Zuill Douglas E. , Angsantikul Pavimol , Zhang Qiangzhe , Gao Weiwei , Zhang Liangfang , Eckmann Lars 
Published: October 2019

AbstractTrichomonas vaginalisis responsible for the most common non‐viral sexually transmitted disease worldwide. Standard treatment is with oral metronidazole or tinidazole, but resistance is emerging and adverse effects can be problematic. Topical treatment offers potential benefits for increasing local drug concentrations while reducing systemic exposure, but none are currently approved for trichomoniasis. The anti‐rheumatic drug, auranofin (AF), was recently discovered to have significant trichomonacidal activity, but has a long plasma half‐life and significant adverse effects. Here, this drug is used as a model to develop a novel topical formulation composed of AF‐loaded nanoparticles (NP) embedded in a thermoresponsive hydrogel for intravaginal administration. The AF‐NP composite gel shows sustained drug release for at least 12 h, and underwent sol–gel transition with increased viscoelasticity within a minute. Intravaginal administration in mice shows excellent NP retention for >6 h and markedly increases local AF levels, but reduces plasma and liver levels compared to oral treatment with a much higher dose. Furthermore, intravaginal AF‐NP gel greatly outperforms oral AF in eliminating vaginal trichomonad infection in mice, while causing no systemic or local toxicity. These results show the potential of the AF‐NP hydrogel formulation for effective topical therapy of vaginal infections.
Droplets as Carriers for Flexible Electronic Devices
Authors: Zhou Mingxing , Wu Ziyue , Zhao Yicong , Yang Qing , Ling Wei , Li Ya , Xu Hang , Wang Cheng , Huang Xian 
Published: October 2019

AbstractCoupling soft bodies and dynamic motions with multifunctional flexible electronics is challenging, but is essential in satisfying the urgent and soaring demands of fully soft and comprehensive robotic systems that can perform tasks in spite of rigorous spatial constraints. Here, the mobility and adaptability of liquid droplets with the functionality of flexible electronics, and techniques to use droplets as carriers for flexible devices are combined. The resulting active droplets (ADs) with volumes ranging from 150 to 600 µL can conduct programmable functions, such as sensing, actuation, and energy harvesting defined by the carried flexible devices and move under the excitation of gravitational force or magnetic force. They work in both dry and wet environments, and adapt to the surrounding environment through reversible shape shifting. These ADs can achieve controllable motions at a maximum velocity of 226 cm min−1 on a dry surface and 32 cm min−1 in a liquid environment. The conceptual system may eventually lead to individually addressable ADs that offer sophisticated functions for high‐throughput molecule analysis, drug assessment, chemical synthesis, and information collection.
The Spacer Cations Interplay for Efficient and Stable Layered 2D Perovskite Solar Cells
Authors: Zhou Ning , Huang Bolong , Sun Mingzi , Zhang Yu , Li Liang , Lun Yingzhuo , Wang Xueyun , Hong Jiawang , Chen Qi , Zhou Huanping 
Published: October 2019

AbstractOrganic spacer cations in layered 2D (A1)2(A2)n−1BnX3n+1 (where A1 is an organic cation acting as a spacer between the perovskite layers, A2 is a monovalent cation, e.g., Cs+,CH3NH3+, CH(NH2)2+) perovskite materials improve the long‐term stability of the resulting solar cells, but hamper their power conversion efficiency due to poor carrier generation/transportation. Rational guidelines are thus required to enable the design of organic spacer cations. Herein, mixed A1 cations are employed in layered 2D perovskites to investigate the interplay between alkylamine cations and unsaturated alkylamine cations. It is revealed that alkylamine spacer cations are able to facilitate precursor assembly, which results in the orientated growth of perovskite crystals. Unsaturated alkylamine cations further lead to reduced exciton binding energy, which improves carrier pathway in the 2D perovskites. By mixing both cations, substantially improved open circuit voltage is observed in the resultant photovoltaic cells with the efficiency of 15.46%, one of the highest one based on (A1)2(A2)3Pb4I13 layered 2D perovskites. The generality of the design principle is further extended to other cation combinations.
Cyanomethylation of β‐Alkoxyaldehydes: Toward a Short Synthesis of Atorvastatin
Authors: Tak Raj Kumar , Noda Hidetoshi , Shibasaki Masakatsu 
Published: October 2019

AbstractThe cyanomethylation of β‐alkoxyaldehydes is described. These elimination‐prone substrates pose a chemoselectivity issue due to the competing elimination and addition pathways. While many commonly used strong Brønsted bases favor elimination,nBuLi effectively promotes the addition of an α‐cyanocarbanion and suppresses the undesired elimination. The cyanomethylated product can be converted to a known intermediate for the synthesis of atorvastatin, an active pharmaceutical ingredient of Lipitor, showcasing the synthetic potential of the current transformation.
Synthesis of Polyampholyte Janus‐like Microgels by Coacervation of Reactive Precursors in Precipitation Polymerization
Authors: Xu Wenjing , Rudov Andrey , Oppermann Alex , Wypysek Sarah , Kather Michael , Schroeder Ricarda , Richtering Walter , Potemkin Igor I. , Wöll Dominik , Pich Andrij 
Published: October 2019

AbstractControlling the distribution of ionizable groups of opposite charge in microgels is an extremely challenging task, which could open new pathways to design a new generation of stimuli‐responsive colloids. Herein, we report a straightforward approach for the synthesis of polyampholyte Janus‐like microgels, where ionizable groups of opposite charge are located on different sides of the colloidal network. This synthesis approach is based on the controlled self‐assembly of growing polyelectrolyte microgel precursors during the precipitation polymerization process. We confirmed the morphology of polyampholyte Janus‐like microgels and demonstrate that they are capable of responding quickly to changes in both pH and temperature in aqueous solutions.
Organocatalytic Enantioselective Synthesis of Tetrasubstituted α‐Amino Allenoates by Dearomative γ‐Addition of 2,3‐Disubstituted Indoles to β,γ‐Alkynyl‐α‐imino Esters
Authors: Yang Junxian , Wang Zheng , He Zeyuan , Li Guofeng , Hong Liang , Sun Wangsheng , Wang Rui 
Published: October 2019

AbstractThe first asymmetric synthesis of tetrasubstituted α‐amino allenoates by a chiral phosphoric acid catalyzed dearomative γ‐addition reaction of 2,3‐disubstituted indoles to β,γ‐alkynyl‐α‐imino esters is reported. This method provides access to a series of highly functionalized tetrasubstituted allenes featuring quaternary stereocenters in high yields, and with excellent regio‐, diastereo‐, and enantioselectivities under mild conditions without by‐product formation. Representative large‐scale reactions and diverse transformations of the products into various scaffolds with potential biological activities render are also disclosed. The mechanism of the reaction was elucidated by control reactions and DFT calculations.
Cellulose Nanocrystal Elastomers with Reversible Visible Color
Authors: Boott Charlotte E. , Tran Andy , Hamad Wadood Y. , MacLachlan Mark J. 
Published: October 2019

AbstractResponsive photonic crystals have potential applications in mechanical sensors and soft displays; however, new materials are constantly desired to provide new innovations and improve on existing technologies. To address this, we report stretchable chiral nematic cellulose nanocrystal (CNC) elastomer composites that exhibit reversible visible color upon the application of mechanical stress. When stretched (or compressed) the colorless materials maintain their chiral nematic structure but the helical pitch is reduced into the visible region, resulting in coloration of the CNC‐elastomer composite. By increasing the percentage elongation of the material (ca. 50–300 %), the structural color can be tuned from red to blue. The color of the materials was characterized by reflectance optical microscopy and reflectance circular dichroism to confirm the wavelength and polarization of the reflected light. We also probed the mechanism of the structural color using 2D‐X‐ray diffraction. Finally, by either water‐patterning the starting CNC film, or by forming a CNC film with gradient color, through masked evaporation, we were able to prepare encoded stretchable chiral nematic CNC‐elastomers.
Microporosity of a Guanidinium Organodisulfonate Hydrogen‐Bonded Framework
Authors: Brekalo Ivana , Deliz David E. , Barbour Leonard J. , Ward Michael D. , Friščić Tomislav , Holman K. Travis 
Published: October 2019

AbstractGuanidinium organosulfonates (GSs) are a large and well‐explored archetypal family of hydrogen‐bonded organic host frameworks that have, over the past 25 years, been regarded as nonporous. Reported here is the only example to date of a conventionally microporous GS host phase, namely guanidinium 1,4‐benzenedisulfonate (p‐G2BDS). p‐G2BDS is obtained from its acetone solvate, AcMe@G2BDS, by single‐crystal‐to‐single‐crystal (SC‐SC) desolvation, and exhibits a Type I low‐temperature/pressure N2 sorption isotherm (SABET=408.7(2) m2 g−1, 77 K). SC‐SC sorption of N2, CO2, Xe, and AcMe by p‐G2BDS is explored under various conditions and X‐ray diffraction provides a measurement of the high‐pressure, room temperature Xe and CO2 sorption isotherms. Though p‐G2BDS is formally metastable relative to the “collapsed”, nonporous polymorph, np‐G2BDS, a sample of p‐G2BDS survived for almost two decades under ambient conditions. np‐G2BDS reverts to zCO2@p‐G2BDS or yXe@p‐G2BDS (y,z=variable) when pressure of CO2 or Xe, respectively, is applied.
Construction of Chiral 2,3‐Allenols through a Copper(I)‐Catalyzed Asymmetric Direct Alkynylogous Aldol Reaction
Authors: Zhong Feng , Xue Qi‐Yan , Yin Liang 
Published: October 2019

AbstractChiral 2,3‐allenols were constructed through copper(I)‐catalyzed asymmetric direct alkynylogous aldol reaction. With aromatic and heteroaromatic aldehydes, the alkynylogous aldol reaction with (R)‐DTBM‐SEGPHOS as the ligand proceeded smoothly to furnish the products in excellent regioselectivity with good to high diastereoselectivity and excellent enantioselectivity. In the cases of aliphatic aldehydes, esters of but‐2‐yn‐1‐ol as the substrates and (R,R)‐Ph‐BPE as the ligand were found to be crucial to get good to high regio‐ and diastereoselectivity. The produced chiral 2,3‐allenols are easily transformed into synthetically useful 2‐furanones through cyclization. Finally, the developed method was successfully applied in the rapid synthesis of two chiral intermediates toward the synthesis of two pharmaceutically active compounds that have been proposed for the treatment of neurological disorders.
Designing Sub‐2 nm Organosilica Nanohybrids for Far‐Field Super‐Resolution Imaging
Authors: Liang Liangliang , Yan Wei , Qin Xian , Peng Xiao , Feng Han , Wang Yu , Zhu Ziyu , Liu Lingmei , Han Yu , Xu Qinghua , Qu Junle , Liu Xiaogang 
Published: October 2019

AbstractStimulated emission depletion (STED) microscopy enables ultrastructural imaging of biological samples with high spatiotemporal resolution. STED nanoprobes based on fluorescent organosilica nanohybrids featuring sub‐2 nm size and near‐unity quantum yield are presented. The spin–orbit coupling (SOC) of heavy‐atom‐rich organic fluorophores is mitigated through a silane‐molecule‐mediated condensation/dehalogenation process, resulting in bright fluorescent organosilica nanohybrids with multiple emitters in one hybrid nanodot. When harnessed as STED nanoprobes, these fluorescent nanohybrids show intense photoluminescence, high biocompatibility, and long‐term photostability. Taking advantage of the low‐power excitation (0.5 μW), prolonged singlet‐state lifetime, and negligible depletion‐induced re‐excitation, these STED nanohybrids present high depletion efficiency (>96 %), extremely low saturation intensity (0.54 mW, ca. 0.188 MW cm−2), and ultra‐high lateral resolution (ca. λem/28).
2D Oligosilyl Metal–Organic Frameworks as Multi‐state Switchable Materials
Authors: Burns David A. , Press Eric M. , Siegler M. A. , Klausen Rebekka S. , Thoi V. Sara 
Published: October 2019

AbstractWe report the synthesis of a set of 2D metal–organic frameworks (MOFs) constructed with organosilicon‐based linkers. These oligosilyl MOFs feature linear SinMe2n(C6H4CO2H)2 ligands (lin‐Sin, n=2, 4) connected by Cu paddlewheels. The stacking arrangement of the 2D sheets is dictated by van der Waals interactions and is tunable by solvent exchange, leading to reversible structural transformations between many crystalline and amorphous phases.