bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue of Metallic Glasses
Authors: Sha Zhendong , Lin Weihui , Poh Leong Hien , Xing Guichuan , Liu Zishun , Wang Tiejun , Gao Huajian 
Published: August 2020

AbstractMetallic glasses (MGs) are often perceived as quintessential structural materials due to their superior mechanical properties such as high strength and large elastic limit. In practical applications, service conditions that introduce cyclic variations in stresses and strains are inevitably involved. The fatigue of MGs is thus a topic of research and practical interest. In this review, a brief introduction on MGs, their applications and challenges, is first provided. Next, experimental studies on fatigue behaviors of both macroscopic and nanoscale MGs are summarized. The range of topics covered include the stress-life behavior, fatigue-crack growth behavior, fatigue-fracture morphology, fatigue-failure mechanisms, as well as the effects of chemical composition, cycling frequency, loading condition, and sample size on the fatigue limits. Finally, recent progresses in simulation studies on the fatigue of MGs are discussed, with an emphasis placed on the atomic-level understanding of the fatigue mechanisms.
Projections of Wind Gusts for New York City Under a Changing Climate
Authors: Comarazamy Daniel , González-Cruz Jorge E. , Andreopoulos Yiannis 
Published: August 2020

Abstract
To determine potential changes in the frequency and intensity of future storm events due to climate change in New York City (NYC), a statistical downscaling technique is proposed. First, a historical benchmark was determined using weather station data from the John F. Kennedy (JFK) and La Guardia (LGA) airports for the period 1973–2017. This historical information was used to perform the bias-correction exercise of near-future (2011–2050) global circulation model (GCM) output (ORNL RegCM4; RCP 8.5). Results show that NYC is projected to experience higher wind gusts under a warming climate for the period 2017–2050 in comparison with the historical data period, with the most extreme event projected to produce a maximum wind gust of approximately 110 mph, a significant increase over the past maximum of 80 mph. The historical 700-year return period event was estimated at 115 mph, while the overall 700-year event (historical and projected) is estimated at 124 mph. The most extreme cases of maximum daily wind gusts are projected to occur during the winter and early spring seasons. No increase in the number of projected tropical storms was observed, but the intensity of the storms is projected to be higher than during the historical period. These changes in extreme wind events could have serious implications for NYC in terms of urban planning, potential power outages, transportation disruptions, impacts on building structures, and public safety.
On the Discretization of the Power-Law Hemolysis Model
Authors: Faghih Mohammad M. , Islam Ahmed , Sharp M. Keith 
Published: August 2020

AbstractFlow-induced hemolysis remains a concern for blood-contacting devices, and computer-based prediction of hemolysis could facilitate faster and more economical refinement of such devices. While evaluation of convergence of velocity fields obtained by computational fluid dynamics (CFD) simulations has become conventional, convergence of hemolysis calculations is also essential. In this paper, convergence of the power-law hemolysis model is compared for simple flows, including pathlines with exponentially increasing and decreasing stress, in gradually expanding and contracting Couette flows, in a sudden radial expansion and in the Food and Drug Administration (FDA) channel. In the exponential cases, convergence along a pathline required from one to tens of thousands of timesteps, depending on the exponent. Greater timesteps were required for rapidly increasing (large exponent) stress and for rapidly decreasing (small exponent) stress. Example pathlines in the Couette flows could be fit with exponential curves, and convergence behavior followed the trends identified from the exponential cases. More complex flows, such as in the radial expansion and the FDA channel, increase the likelihood of encountering problematic pathlines. For the exponential cases, comparison of converged hemolysis values with analytical solutions demonstrated that the error of the converged solution may exceed 10% for both rapidly decreasing and rapidly increasing stress.
Design, Analysis, and Manufacture of an Axial Length-Saving Disk-Oriented Engine
Authors: Staton Bennett M. , Bohan Brian T. , Polanka Marc D. , Goss Larry P. 
Published: August 2020

Abstract
A disk-oriented engine was designed to reduce the overall length of a gas turbine engine, combining a single-stage centrifugal compressor and radial in-flow turbine (RIT) in a back-to-back configuration. The focus of this research was to understand how this unique flow path impacted the combustion process. Computational analysis was accomplished to determine the feasibility of reducing the axial length of a gas turbine engine utilizing circumferential combustion. The desire was to maintain circumferential swirl from the compressor through a U-bend combustion path. The U-bend reverses the outboard flow from the compressor into an integrated turbine guide vane in preparation for power extraction by the RIT. The computational targets for this design were a turbine inlet temperature of 1300 K, operating with a 3% total pressure drop across the combustor, and a turbine inlet pattern factor (PF) of 0.24 to produce a cycle capable of creating 668 N of thrust. By wrapping the combustion chamber about the circumference of the turbomachinery, the axial length of the entire engine was reduced. Reallocating the combustor volume from the axial to radial orientation reduced the overall length of the system up to 40%, improving the mobility and modularity of gas turbine power in specific applications. This reduction in axial length could be applied to electric power generation for both ground power and airborne distributive electric propulsion. Computational results were further compared to experimental velocity measurements on custom fuel–air swirl injectors at mass flow conditions representative of 668 N of thrust, providing qualitative and quantitative insight into the stability of the flame anchoring system. From this design, a full-scale physical model of the disk-oriented engine was designed for combustion analysis.
Flow Boiling in a Parallel Strip Fin Heat Sink With Nonuniform Heat Flux Conditions
Authors: Ren Kexian , Miao Ze , Yang Bo , Yang Tongzhi , Yuan Weixing 
Published: August 2020

Abstract
This study investigates the thermal performance of a parallel strip fin heat sink (PSFHS) under various heat flux conditions at a flowrate of 100 ml/min, including uniform heat flux and nonuniform heat flux. The heat sink consists of 150 fins with a width of 1 mm, a height of 5.5 mm, and a pitch of 1 mm and has a Z-type inlet/outlet arrangement. Nine separate heaters offer thermal load to the heat sink in order to provide a uniform or nonuniform heat flux. The flow boiling process is captured by a high-speed camera. The temperatures of the heaters have been measured under the uniform and nonuniform heat flux conditions. In addition, the pressure drops inside the heat sink are also obtained. A minichannel heat sink (MCHS) with the same channel dimensions and inlet/outlet configuration is tested too. A comparison between MCHS and PSFHS is discussed in detail, which helps to understand the flow boiling characteristic in PSFHS.
The Cooling Performance of Mixed Convection in a Ventilated Enclosure With Different Ports Configurations
Authors: Dhahad Hayder A. , Al-Sumaily Gazy F. , Habeeb Laith J. , Thompson Mark C. 
Published: August 2020

Abstract
Mixed convection heat transfer in a vertically oriented air-cooled square enclosure is simulated numerically using the finite volume method. The vertical left wall being heated and all others are considered insulated. The effects of six opposite and staggered inlet/outlet openings' locations over the top and bottom walls are investigated, with different sizes of the opening height (0.05 ≤d/H≤ 0.3). The objective is to figure out the better size and location of inlet and outlet to acquire more efficient cooling system in the enclosure by maximizing the heat removal rate. This is conducted over ranges of the governing parameters, which are the Richardson number (0 ≤Ri≤ 30) and the Reynolds number (50 ≤Re≤ 250). The results show that the level of heat transfer enhancement increases with increasing the opening height, with an optimal size of d/H = 0.25 for obtaining maximum heat removal, for all Richardson and Reynolds numbers. The results also indicate that the higher heat dissipation occurs when the cold air is injected vertically near the hot wall and exits the enclosure from the opposite or staggered outlet, for all Richardson and Reynolds numbers.
Evidence for the Effectiveness of the Feldenkrais Method
Authors: Stephens James , Hillier Susan 
Published: August 2020

The Feldenkrais method (FM) is a process that uses verbally and manually guided exploration of novel movements to improve individuals’ self-awareness and coordination. This paper reviews recent literature evaluating the therapeutic value of the FM for improving balance, mobility, and coordination and its effectiveness for management of chronic pain. The authors also explore and discuss studies that have investigated some of the other bodily effects and possible mechanisms of action, such as (a) the process of learning itself, (b) focus of attention during motor learning, (c) autonomic regulation, and (d) body image. They found that research clearly supports the effectiveness of the FM for improvement of balance and chronic pain management. The exploration into mechanisms of action raises interesting questions and possibilities for further investigation.
Molecular and clinical characteristics of monogenic diabetes mellitus in southern Chinese children with onset before 3 years of age
Authors: Lin Yunting , Sheng Huiying , Ting Tzer Hwu , Xu Aijing , Yin Xi , Cheng Jing , Mei Huifen , Shao Yongxian , Zeng Chunhua , Zhang Wen , Rao Min , Liu Li , Li Xiuzhen 
Published: August 2020

IntroductionA specific molecular diagnosis of monogenic diabetes mellitus (MDM) will help to predict the clinical course and guide management. This study aims to identify the causative genes implicated in Chinese patients with MDM with onset before 3 years of age.Research design and methods71 children with diabetes mellitus (43 diagnosed before 6 months of age, and 28 diagnosed between 6 months and 3 years of age who were negative for diabetes-associated autoantibodies) underwent genetic testing with a combination strategy of Sanger sequencing, chromosome microarray analysis and whole exome sequencing. They were categorized into four groups according to the age of onset of diabetes (at or less than 6 months, 6 to 12 months, 1 to 2 years, 2 to 3 years) to investigate the correlation between genotype and phenotype.ResultsGenetic abnormalities were identified in 39 of 71 patients (54.93%), namelyKCNJ11(22),ABCC8(3),GCK(3),INS(3),BSCL2(1) and chromosome abnormalities (7). The majority (81.40%, 35/43) of neonatal diabetes diagnosed less than 6 months of age and 33.33% (3/9) of infantile cases diagnosed between 6 and 12 months of age had a genetic cause identified. Only 11.11% (1/9) of cases diagnosed between 2 and 3 years of age were found to have a genetic cause, and none of the 10 patients diagnosed between 1 and 2 years had a positive result in the genetic analysis. Vast majority or 90.48% (19/21) of patients withKCNJ11(19) orABCC8(2) variants had successful switch trial from insulin to oral sulfonylurea.ConclusionsThis study suggests that genetic testing should be given priority in diabetes cases diagnosed before 6 months of age, as well as those diagnosed between 6 and 12 months of age who were negative for diabetes-associated autoantibodies. This study also indicates significant impact on therapy with genetic cause confirmation.
Association between a biomarker of glucose spikes, 1,5-anhydroglucitol, and cancer mortality
Authors: Kira Sakurako , Ito Chikako , Fujikawa Rumi , Misumi Munechika 
Published: August 2020

Introduction1,5-Anhydroglucitol (1,5-AG) is a biomarker of glucose spikes. To evaluate the effect of acute glucose excursions on cancer death, we clarified the association between 1,5-AG and cancer mortality among Japanese individuals with normal glucose tolerance.Research design and methodsWe measured 1,5-AG in 6783 (2842 men, 3941 women) individuals with normal fasting and 2-hour plasma glucose who received a 75 g oral glucose tolerance test between 1994 and 2012. They were followed for mortality until August 2013. A systematic review of death certificates was used to confirm the cause of death. We divided the participants into four groups according to the quartile of 1,5-AG level at registration. We used Cox regression to clarify the association between 1,5-AG levels and cancer mortality with multivariate adjustment for possible confounders.ResultsDuring the follow-up period (median, 10.0 years), 140 men and 109 women died of cancer. The HR for cancer mortality of the lowest quartile group was higher than that of the highest quartile group in men (HR, 2.62; 95% CI, 1.60 to 4.41) and in women (HR, 1.47; 95% CI, 0.88 to 2.47). These associations were not attenuated with further adjustment for HbA1c.Conclusions1,5-AG was associated with high risk of cancer mortality in Japanese men after adjustment for HbA1c.
The civil registration system is a potentially viable data source for reliable subnational mortality measurement in India
Authors: Rao Chalapati , Gupta Mamta 
Published: August 2020

IntroductionThe Indian national Civil Registration System (CRS) is the optimal data source for subnational mortality measurement, but is yet under development. As an alternative, data from the Sample Registration System (SRS), which covers less than 1% of the national population, is used. This article presents a comparison of mortality measures from the SRS and CRS in 2017, and explores the potential of the CRS to meet these subnational data needs.MethodsData on population and deaths by age and sex for 2017 from each source were used to compute national-level and state-level life tables. Sex-specific ratios of death probabilities in five age categories (0–4, 5–14, 15–29, 30–69, 70–84) were used to evaluate CRS data completeness using SRS probabilities as reference values. The quality of medically certified causes of death was assessed through hospital reporting coverage and proportions of deaths registered with ill-defined causes from each state.ResultsThe CRS operates through an extensive infrastructure with high reporting coverage, but child deaths are uniformly under-reported, as are female deaths in many states. However, at ages 30–69 years, CRS death probabilities are higher than the SRS values in 15 states for males and 10 states for females. SRS death probabilities are of limited precision for measuring mortality trends and differentials. Data on medically certified causes of death are of limited use due to low hospital reporting coverage.ConclusionsThe Indian CRS is more reliable than the SRS for measuring adult mortality in several states. Targeted initiatives to improve the recording of child and female deaths, to strengthen the reporting and quality of medically certified causes of death, and to promote use of verbal autopsy methods can establish the CRS as a reliable source of subnational mortality statistics in the near future.
Effectiveness of primary care gatekeeping: difference-in-differences evaluation of a pilot scheme in China
Authors: Xu Jin , Powell-Jackson Timothy , Mills Anne 
Published: August 2020

IntroductionThis paper evaluates the effectiveness of a gatekeeping pilot in shifting resources and patient visits from hospitals to primary care facilities under the Chinese New Rural Cooperative Medical Scheme.MethodsWe applied a difference-in-differences regression analysis using claims data from a pilot district in northern China. The study covered 200 685 enrollees in 17 townships in 2012 and followed-up the townships over 12 year-quarters until the end of 2014.ResultsThe gatekeeping pilot led to significantly more patients visiting primary care facilities (55.3%, p=0.001), but there was little evidence of increased ambulatory spending on primary care (1.6%, p=0.884). The pilot reduced hospital visits by 23.9% (p=0.048) and ambulatory spending at the hospitals by 22.4% (p=0.011).ConclusionsThis first impact evaluation of gatekeeping outside high-income countries found that gatekeeping policy did not seem to have expanded the care provided by primary care facilities, despite an increased volume of claimed visits. Although claimed patient visits and expenditure at hospitals reduced, we suspect this may have been because patients found it either cumbersome or difficult to obtain reimbursement for their care.
Illicit drug use and self-reported vision loss among military service members or veterans
Authors: McDaniel Justin Tyler , Jenkins W D , Albright D L , Null D , McIntosh S , McDaniel M R 
Published: August 2020

IntroductionLittle is known about differences in vision loss prevalence among service members or veterans (SMVs) and civilians; further, no study has compared vision loss risk factors in these two populations. As such, we seek to fill this gap in the literature.MethodsIn this cross sectional study, we obtained data on 106 SMVs and 1572 civilians from the 2013–2018 National Health and Nutrition Examination Surveys. We compared the prevalence of or mean values of vision loss risk factors between SMVs and civilians using the Wald χ2 statistic or Kruskal-Wallis test. Further, we examined the relative strength of 17 vision loss risk factors in predicting self-reported vision loss via Firth’s logistic regression.ResultsSMVs had a significantly higher prevalence of illicit drug use (20.75% vs 13.62%) and HIV (1.89% vs 0.41%), while civilians had a higher prevalence of poor dietary habits (7.61% vs 13.21%). SMVs also had higher mean values of systolic blood pressure (125.85 vs 122.53 mmHg), pack years of cigarette smoking (8.29 vs 4.25), and sedentary minutes per day (379.15 vs 337.07 min). More SMVs (8.49%) self-reported vision loss than civilians (4.48%). After adjustment for covariates, illicit drug use (adjusted β coefficient=0.72, p=0.02) was associated with self-reported vision loss.ConclusionsThis study indicates that self-reported vision loss among SMVs is more prevalent than among civilians, and vision loss in SMVs is associated with severe or prolonged illicit drug use.
Cost-effectiveness analysis of ixekizumab versus secukinumab in patients with psoriatic arthritis and concomitant moderate-to-severe psoriasis in Spain
Authors: Schweikert Bernd , Malmberg Chiara , Núñez Mercedes , Dilla Tatiana , Sapin Christophe , Hartz Susanne 
Published: August 2020

ObjectiveTo conduct a cost-effectiveness analysis from the perspective of the Spanish National Health System (NHS) comparing ixekizumab versus secukinumab.DesignA Markov model with a lifetime horizon and monthly cycles was developed based on the York model. Four health states were included: a biological disease-modifying antirheumatic drug (bDMARD) induction period of 12 or 16 weeks, maintenance therapy, best supportive care (BSC) and death. Treatment response was assessed based on both Psoriatic Arthritis Response Criteria (PsARC) and ≥90% improvement in the Psoriasis Area Severity Index score (PASI90). At the end of the induction period, responders transitioned to maintenance therapy. Non-responders and patients who discontinued maintenance therapy transitioned to BSC. Clinical efficacy data were derived from a network meta-analysis. Health utilities were generated by applying a regression analysis to Psoriasis Area Severity Index and Health Assessment Questionnaire‒Disability Index scores collected in the ixekizumab SPIRIT studies. Results were subject to extensive sensitivity and scenario analysis.SettingSpanish NHS.ParticipantsA hypothetical cohort of bDMARD-naïve patients with psoriatic arthritis and concomitant moderate-to-severe psoriasis was modelled.InterventionsIxekizumab and secukinumab.ResultsIxekizumab performed favourably over secukinumab in the base-case analysis, although cost savings and quality-adjusted life-year (QALY) gains were modest. Total costs were €153 901 compared with €156 559 for secukinumab (difference −€2658). Total QALYs were 9.175 vs 9.082 (difference 0.093). Base-case results were most sensitive to the annual bDMARD discontinuation rate and the modification of PsARC and PASI90 response to ixekizumab or secukinumab.ConclusionIxekizumab provided more QALYs at a lower cost than secukinumab, with differences being on a relatively small scale. Sensitivity analysis showed that base-case results were generally robust to changes in most input parameters.Trial registration numberSPIRIT-P1: NCT01695239; Post-results, SPIRIT-P2: NCT02349295; Post-results.
Ozone exposure and health effects: a protocol for an umbrella review and effect-specific systematic maps
Authors: Zhao Tianyu , Markevych Iana , Janßen Christian , Nowak Dennis , Steckling-Muschack Nadine , Heinrich Joachim 
Published: August 2020

IntroductionAmbient ozone exposure may be adverse to health. Since the reported associations between ozone and health effects are heterogeneous and the underlying pathways are indistinct, the overall relationship remains unclear. Only a few overall syntheses of the evidence regarding ozone and health effects are available to date.Methods and analysisWe plan to summarise the current evidence on ozone-related health effects systematically. First, to identify the possible associations between ambient ozone exposure and health outcomes, we will conduct an umbrella review. PubMed, Web of Science and grey literature will be searched for systematic reviews on exposure to ambient ozone and any possible health endpoints published before 31 May 2019. Data selection and extraction will be carried out by one reviewer, and a second reviewer will check the agreement of a sample of the studies. The methodological quality of the eligible systematic reviews and level of evidence regarding ozone and every specific health effect will be evaluated. Second, for each of the identified effects with a high level of evidence, comprehensive information retrievals will be conducted, considering both epidemiological and experimental studies. The study selection and data mapping will be carried out by one reviewer and checked by the second reviewer. We will summarise the information of the filtered epidemiological and experimental studies to conduct several systematic maps presenting the currently available evidence for the specific health effect. Because the association between ozone exposure and chronic obstructive pulmonary disease (COPD) is relatively well investigated, we will at least conduct one systematic map of ozone and COPD.Ethics and disseminationNo ethical approval is required for this study. The completed umbrella review and systematic maps will be considered for publication and presentation. We will additionally upload the relevant data to publicly accessible online databases.PROSPERO registration numberCRD42019123064.