bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early low complication rate of ceramic-on-ceramic total hip arthroplasty by direct anterior approach
Authors: Henri Bauwens Paul , Fary Camdon , Servien Elvire , Lustig Sébastien , Batailler Cécile 
Published: August 2020

Introduction: Ceramic-on-ceramic couplings are an alternative bearing surface to reduce the problems related to polyethylene wear and debris. However, ceramic articulations have their own risk of unique complications: fracture, squeaking, or dislocation. Few studies have assessed the outcomes of ceramic-on-ceramic total hip arthroplasties (THA) by direct anterior approach (DAA). The aim was to evaluate the early complications and revision rate of ceramic-on-ceramic THA by DAA.Material: A retrospective single-center study of 116 consecutive THAs was performed by DAA (106 patients) with ceramic-on-ceramic bearing from January 2015 to February 2018 with a minimum 24 months of follow-up. No patients were lost to follow-up. The mean age was of 55.3 years ± 11.3. The same cementless acetabular shell with a Biolox Delta ceramic insert and head were used. The complication and revision rates were collected at the last follow-up. The positioning of the acetabular implant was assessed on standard radiographs. Postoperative clinical outcomes were assessed by the Harris Hip Score.Results: At a mean follow-up of 31.9 months ± 5.5, no THA was revised. Five patients had late complications: 3 squeaking (2.6%) and 2 psoas impingements (1.7%) and were managed conservatively. All patients had satisfactory bony ingrowth of acetabular component, with no radiolucent lines and no osteolysis. Eight patients (6.9%) had an anterior overhang of the cup. The mean overhang for these patients was 4.1 mm. 111 hips (96%) were perceived as forgotten or having no limitations.Conclusion: This ceramic-on-ceramic coupling and shell by DAA produced excellent clinical outcomes and implant survival rate at a minimum two-year follow-up study. No serious complication was observed during the follow-up.
Die Rolle der Frau in der Medizin
Authors: von Einsiedel Regina 
Published: August 2020

ZUSAMMENFASSUNGGesellschaftspolitisch wird die Chancengleichheit der Frauen in der Medizin propagiert, sie ist 2020 aber immer noch nicht ausreichend umgesetzt. Neben den Genderaspekten und ungleichen Karrierechancen klagen viele Ärztinnen über alltägliche Doppel- oder Mehrfachbelastungen sowie über Barrieren in den verschiedenen Berufs- und Ausbildungsphasen. Entwickeln sich diese Probleme zu individuellen Dauerstressoren, können Befindlichkeitsstörungen, ein Burnout oder eine psychische Störung die Folge sein. Psychische Symptome können die Lebensqualität und Arbeitsfähigkeit der Betroffenen empfindlich einschränken. Die berufsbedingten Krisenherde der Medizinerinnen werden anhand der Literatur dargestellt. Im Fokus steht das präventive und interventionale schematherapiefokussierte Coaching bei berufsbedingtem Burnout als Weg aus der Krise.
Titanocene-Catalyzed Regiodivergent Epoxide Opening – From Desymmetrizing meso-Epoxides to Regiodivergent Arylation of Epoxides
Authors: Gansäuer Andreas , Weißbarth Hendrik , Mühlhaus Felix 
Published: August 2020

While SN2 based desymmetrization of meso-epoxides has been extensively researched, the more general regioselective opening of cis-1,2 substituted epoxides via SN2 mechanism remains elusive. This short review outlines, how this limitation could be overcome by parting with SN2 and moving towards a radical-based mechanism. The development and refinement of the titanocene(III)-catalyzed regiodivergent epoxide opening (REO) is described.1	Introduction to Asymmetric Catalysis2	From Enantiodivergent to Regiodivergent Epoxide Opening3	Regiodivergent Arylation of Epoxides4	Conclusion
A First-Case Report of Pycnodysostosis in an Omani Boy
Authors: Al-Araimi Musallam , Al-Hosni Aliya , Maimani Ashwaq Al 
Published: August 2020

AbstractHere we reported on the genetic findings of a 9-year-old Omani boy with a rare inherited bone disorder. The patient's clinical features include dysmorphic facial features, short stature, and skeletal abnormalities. Exome sequence of the patient's deoxyribonucleic acid revealed a variant in the cathepsin K gene, which was confirmed by Sanger sequencing. These findings established the diagnosis of pycnodysostosis (PKND). To the best of the authors' knowledge, this case is the first case to be reported in the Gulf Cooperative Region of the novel PKND with molecular confirmation.
Polymorphism of Proteasomal Genes Can Be a Risk Factor for Systemic Autoimmune Diseases in Children
Authors: Bakutenko Ivan Y. , Hileuskaya Irena D. , Nikitchenko Natalia V. , Sechko Elena V. , Tchitchko Alexej M. , Batyan Galina M. , Sukalo Alexander V. , Ryabokon Nadezhda I. 
Published: August 2020

AbstractThe study aimed to assess the involvement of three proteasomal genes, PSMA6, PSMC6, and PSMA3, in autoimmune pathogenesis by analyzing associations between single nucleotide polymorphisms and systemic rheumatic diseases with a different autoimmune component: juvenile idiopathic arthritis (JIA), the juvenile form of systemic lupus erythematosus, and Kawasaki's disease (KD). Our results showed that the PSMA6 (rs1048990) polymorphism can be a risk factor for JIA (false discovery rate q ≤ 0.090), while PSMA3 (rs2348071) has a tendency to be nonspecific and is shared with JIA and other autoimmune diseases, including KD, an illness with very low autoimmune activity and high autoinflammation.
NFAT5, which protects against hypertonicity, is activated by that stress via structuring of its intrinsically disordered domain
Authors: Kumar Raj , DuMond Jenna F. , Khan Shagufta H. , Thompson E. Brad , He Yi , Burg Maurice B. , Ferraris Joan D. 
Published: August 2020

Significance
NFAT5 mediates protection from adverse effects of hypertonicity. Cells, e.g. kidney, in hypertonic conditions take up salts and protective organic osmolytes. By mechanisms not fully understood, NFAT5 is activated and induces genes including those that code enzymes responsible for synthesizing protective osmolytes. We show that in solution the NFAT5 NTD, which contains one of NFAT5′s three transcription activation domains, undergoes hypertonicity- and/or osmolyte-induced disorder-to-order conformational rearrangement. In its more folded conformation, interaction of NFAT5 NTD with specific proteins is enhanced, including that with high mobility group protein (HMGI-C), which has been shown to protect against apoptosis. These findings suggest that in vivo, increased intracellular ionic strength, coupled with osmolytes, may directly activate NFAT5. They encourage further pursuit of this possibility.
ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment
Authors: Li Na , Kang Yuqi , Wang Lingling , Huff Sarah , Tang Rachel , Hui Hui , Agrawal Kriti , Gonzalez Gwendolyn Michelle , Wang Yinsheng , Patel Sandip Pravin , Rana Tariq M. 
Published: August 2020

SignificanceN6-methylation of adenosine (m6A) RNA modification plays important roles in development and tumorigenesis. The functions and mechanisms of m6A demethylases during cancer immunotherapy is still unclear. Here we employed melanoma and colon syngeneic mouse models to study the roles of m6A demethylases ALKBH5 and FTO during anti–PD-1 antibody and GVAX vaccination therapy. We found that ALKBH5 knockout in tumor cells enhances efficacy of immunotherapy and prolonged mouse survival. ALKBH5 modulates target gene expression and gene splicing, leading to changes of metabolite contents, such as lactate in tumor microenvironment, which regulates suppressive lymphocytes Treg and myeloid-derived suppressor cell accumulations. Importantly, by using ALKBH5-specific inhibitor, we observed the similar phenotype, indicating future translational application of our findings.
Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells
Authors: Susanto Evelyn , Marin Navarro Ana , Zhou Leilei , Sundström Anders , van Bree Niek , Stantic Marina , Moslem Mohsen , Tailor Jignesh , Rietdijk Jonne , Zubillaga Veronica , Hübner Jens-Martin , Weishaupt Holger , Wolfsberger Johanna , Alafuzoff Irina , Nordgren Ann , Magnaldo Thierry , Siesjö Peter , Johnsen John Inge , Kool Marcel , Tammimies Kristiina , Darabi Anna , Swartling Fredrik J. , Falk Anna , Wilhelm Margareta 
Published: August 2020

Significance
Here we describe and utilize a model of medulloblastoma, a malignancy accounting for 20% of all childhood brain cancers. We used iPS-derived neural stem cells with a familial mutation causing aberrant SHH signaling. We show that these cells, when transplanted into mouse cerebellum, form tumors that mimics SHH-driven medulloblastoma, demonstrating the development of cancer from healthy neural stem cells in vivo. Our results show that reprogramming of somatic cells carrying familial cancer mutations can be used to model the initiation and progression of childhood cancer.
Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection
Authors: Lane Rebecca K. , Guo Hongyan , Fisher Amanda D. , Diep Jonathan , Lai Zhao , Chen Yidong , Upton Jason W. , Carette Jan , Mocarski Edward S. , Kaiser William J. 
Published: August 2020

Significance
Human cytomegalovirus (HCMV) is a β-herpesvirus that establishes life-long infection, leaving the risk of persistent reactivation and disease. Inhibition of viral entry into susceptible cells is an attractive strategy to prevent infection. MCMV is a surrogate to model host-pathogen interactions; however, the precise mechanism of MCMV entry remains incomplete. Here, we utilized a pronecroptotic form of MCMV as a strategy to perform a genome-wide forward genetic screen to identify host factors essential for infection. We characterize VEGF receptor Nrp-1 as a novel mediator of MCMV infection required for viral gene expression, replication, and necroptosis induction. Our observations define Nrp-1 as a key cellular factor that facilitates MCMV infection and may be an entry receptor for the virus.
The whale shark genome reveals how genomic and physiological properties scale with body size
Authors: Weber Jessica A. , Park Seung Gu , Luria Victor , Jeon Sungwon , Kim Hak-Min , Jeon Yeonsu , Bhak Youngjune , Jun Je Hun , Kim Sang Wha , Hong Won Hee , Lee Semin , Cho Yun Sung , Karger Amir , Cain John W. , Manica Andrea , Kim Soonok , Kim Jae-Hoon , Edwards Jeremy S. , Bhak Jong , Church George M. 
Published: August 2020

Significance
We sequenced and analyzed the genome of the endangered whale shark, the largest fish on Earth, and compared it to the genomes of 84 other species ranging from yeast to humans. We found strong scaling relationships between genomic and physiological features. We posit that these scaling relationships, some of which were remarkably general, mold the genome to integrate metabolic constraints pertaining to body size and ecological variables such as temperature and depth. Unexpectedly, we also found that the size of neural genes is strongly correlated with lifespan in most animals. In the whale shark, large gene size and large neural gene size strongly correlate with lifespan and body mass, suggesting longer gene lengths are linked to longer lifespans.
Revealing the intersectoral material flow of plastic containers and packaging in Japan
Authors: Nakatani Jun , Maruyama Tamon , Moriguchi Yuichi 
Published: August 2020

Significance
Plastic containers and packaging are typical single-use plastics. It is essential to quantitatively identify who uses plastic containers and packaging to supply products, and who purchases these products and discards their containers and packaging. We develop a model for material flow analysis using input–output tables (IO-MFA) that specifies the intersectoral flow of plastics as containers and packaging. We apply the model to the nationwide material flow of plastics in Japan and discuss which types of plastics should be collected from what sources to achieve the recycling target set by the government. This IO-MFA model could be applied to other countries that publish input–output tables and contribute a basis for strategies to solve the problems associated with single-use plastics.
Synthetic nanobodies as angiotensin receptor blockers
Authors: McMahon Conor , Staus Dean P. , Wingler Laura M. , Wang Jialu , Skiba Meredith A. , Elgeti Matthias , Hubbell Wayne L. , Rockman Howard A. , Kruse Andrew C. , Lefkowitz Robert J. 
Published: August 2020

Significance
The G protein-coupled receptor (GPCR) family is responsible for regulating much of human physiology, and GPCRs have become the most successful target class for drug development. Although many biologics have gained clinical approval, GPCR-targeted drugs remain almost exclusively small molecules, and developing GPCR-targeted antibodies remains challenging and often unsuccessful. We describe a methodology to isolate antibody fragment antagonists of a peptide-binding GPCR, and we show that one of these antibody fragments can be used to modulate blood pressure in vivo in mice. Antibody-based approaches may be useful in treating conditions where small-molecule drugs cannot be developed or where the unique pharmacological properties of antibodies are desirable.
Efficiency nonminimally supported design for two parameters weighted exponential model
Authors: Widiharih T , Mukid M A , Mustafid  , Prahutama A 
Published: August 2020

Abstract
Minimally supported design is a design with the number of supported design equal to the number of parameters in the model. Locally D-optimal design for weighted exponential model is minimally supported design with uniform weight. The standardized variance of D-optimal design is less than or equal the number of parameters, and maximized the standardized variance at the supported designs. We construct an alternative design by adding one supported design. Nonminimally supported design is obtain from supported design of D-optimal design plus one supported design in three ways, by adding one of them, by adding the average of them or by adding one supported design around them. We compare nonminimally supported designs in terms efficiency, standardized variance, and propose design that are efficient and practically convenient for practitioners.
Development Of Blcs Learning Devices Based On Traditional Or Computer Explorative Media To Improve Mathematical Problem-Solving Skills
Authors: Ina Sukma Dewi Ni Wayan , Made Ardana I , Suweken Gede 
Published: August 2020

Abstract
This study aimed to develop a valid, practical and effective BLCS learning devices to improve problem solving skills. The BLCS (Bruner’s theory, Local Culture, and Scaffolding) learning devices were computer or traditional explorative media supported by lesson plans, worksheets and formative tests. This development research was based on Plomp’s procedure and used research instruments in the form of observation sheets, questionnaires, interview guidelines, and description tests. In the preliminary research stage, several learning problems were found, mainly learning did not lead the students to find mathematical concepts and the exercises given were not mathematical problems. Furthermore, the prototyping phase carried out several stages such as (1) the development of initial learning devices as a solution to the problem, (2) conducting validation tests by three validators, (3) the trial limited to 12 students to obtain practicality data, and (4) the field trial I on 40 students to get practicality and effectiveness data. In the final stage, was carried out a semi-summative assessment called field trials II on 40 students and provided results in the form of a final BLCS learning devices that was valid, practical and effective. The discovery of mathematical concepts was facilitated by computer or traditional explorative media which contain real problems based on local culture and was supported by lesson plans, worksheets, and formative tests with each of their characteristics so that problem solving abilities could also be well honed.
The Influence of Knisley Mathematical Learning Model with Geogebra Towards Mathematical Connection and Mathematical Disposition
Authors: Jatiariska I G A , Sariyasa  , Astawa I W P 
Published: August 2020

AbstractThis research was aimed at comparing mathematical connection and mathematical disposition of student who were taught using Knisley Mathematical learning model with Geogebra and those who learned using conventional learning. This research used quasi experiment method with post-test only control group design. The research population consisted of 213 grade tenth science student at SMA Negeri 6 Denpasar. In addition, cluster random sampling was used to get 2 groups sample. The experimental group was learned using Knisley Mathematical learning model with Geogebra and the control group was treated with conventional learning. The data was collected using test and non-test technique and analysed using Manova. The result showed that mathematical connection and mathematical disposition of students who were taught using Knisley Mathematical learning model with Geogebra were better than students who were taught using conventional learning (F = 4,410; p = 0,016). Knisley Mathematical learning model with Geogebra give students more chance to explore their mind and idea in solving problem, so that can improve their mathematical connection and mathematical disposition.
Developing Realistics Mathematics Education (Rme) Based Mathematics Teaching Video To Advance Higher Order Thinking Skills (Hots) In Cognitive Level Of Vocational School Students
Authors: Wayan Sumandya I , Gusti Agung Handayani I , Wayan Eka Mahendra I 
Published: August 2020

Abstract
The research method for this study is design method with developing approach. This developing research aims at obtaining the learning video of Mathematics that oriented on RME with valid quality, pragmatics and effective to increase the skill of higher level thinking of Vocational School students. It consists of three stages, i.e. Preliminary research, prototyping and assesment. This is applied in all vocational schools in Badung regency. The result of this research is learning video of valid equation linear, practice and effectives and video which able to advance the Higher Order Thinking Skills (HOTS) in cognitive level of Vocational School students.
Validity of Introduction to Basic Mathematics Teaching Materials Based on Conceptual Understanding Procedures Models and Character Education
Authors: Juniantari M , Mahayukti G A , Gita I N , Suryawan I P P 
Published: August 2020

AbstractThe purpose of this study was to develop a valid introduction to basic mathematics teaching materials based on conceptual understanding procedures models and character education. It aims to improve the student’s understanding of concepts. Plomp’s development procedure was applied to conduct the study which consists of five stages, namely: (1) preliminary investigation, (2) design, (3) realization/construction, (4) test, evaluation, and revision, and (5) implementation. In the first year, this study has reached the stage of testing, evaluation, and revision to determine the validity of teaching materials. The validity of the content can be viewed on the suitability of teaching materials developed by the theory of the development and characteristics of the learning model. The validity of the construct can be viewed on the appropriateness of each component of teaching materials with the characteristics of the learning model obtained from the expert. The construct validity of teaching materials is very valid. Advice from validator used as a reference for the revision of teaching materials. The next step is doing limited implementation to see the practicality and effectiveness of teaching materials.
Depletion of dark matter within globular clusters
Authors: Ardi E , Baumgardt H 
Published: August 2020

Abstract
Gravitationally bound group of stars which are identified as globular clusters are known to have a small amount of dark matter. Assuming that globular clusters are formed within dark matter halos, they must have lost significant amount of dark matter. Observations of globular clusters reported flattening velocity dispersion on the outskirt clusters. This could be a sign of existence of dark matter. Theoretically, dynamical processes such as dynamical friction and mass segregation and tidal stripping could be responsible for the depletion of dark matter from the cluster center. Numerical simulations are conducted to follow the evolution of the models of globular clusters composed out of stars and dark matter particles. The results show that the dark matter is depleted from the center of globular clusters due to dynamical friction and mass segregation of stars. An external tidal field from a Milky Way like galaxy effects to deplete the dark matter in the outer part of the clusters. However, within the Hubble time, about 80 % of dark matter’s initial values still remain in the outer part of clusters. This might explain the existence of significant amount of dark matter in the outer part of observed clusters.
Development of Physics Learning Device Based Science Technology Society (STS) Learning Model to Improve Scientific Attitude and Students’ Understanding Concept of X Grade High School
Authors: K Dewi I G A C , Sadia I W , Sudria I B N 
Published: August 2020

Abstract
This research is the development of physics learning device based on the learning model of Science Technology Society (STS) which is synthesized with a scientific approach. This research aimed to produce learning device in the form of lesson plans, student book, student worksheets, and teacher handbook on momentum and impulse material that fulfilled of valid, practical, and effective criteria. The development of this learning device used 4-D model consisting of four main stages, as follows: define, design, develop, and disseminate. The device development was only carried out until the develop stage. The results data included the result of requirement analysis, product planning, validity, practicality, and effectiveness of the device. The research results were obtained (1) the learning device developed presenting issues related to momentum and impulse material, (2) the validity of the student book is evaluated with very valid category and the validity of teacher handbook is evaluated with valid category. (3) the result of practicality was measured from the implementation of learning device, teachers’ response, and students’ response with very practical category, (4) developed device effectively improve scientific attitude and students’ understanding concept.
Alkaline activation of marble-like carbon structure and it’s application for inflammatory adsorption
Authors: Ulfa Maria , Mangesti Gumilar Ivara , Prasetyoko Didik 
Published: August 2020

Abstract
For the first time, carbon microspheres successfully synthesized by using block copolymer F127 combined with gelatin, sucrose, and H2SO4 as soft template, source carbon, catalyst, respectively. The following step of synthesis are hydrothermal treatment, evaporation, carbonization and pyrolysis treatment under nitrogen flow. Microspheres carbon results have activated by a 10% KOH solution at room temperature for 12, 24, and 48 h, respectively then characterized by SEM and FTIR. The Activated microspheres carbon have used for ibuprofen adsorption. The characterization results showed that carbon microspheres carbon as marbles-like morphology with a diameter of 1-10 μm completed by C-OH, CO2, C≡N, -CNN, C=O, COO-, C=C,CK functional groups as the most. So this study shows that increasing activation time of the microsphere carbon have enhanced the equilibrium time and which is reach equilibrium at range 15-25 min and adsorption capacity range at 55.1-59.9 mg g−1. So carbon microspheres in general conclusion could be potentially as Drug Delivery material.