bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaspin inhibits ferroptosis: A new hope for treating myocardial ischemia–reperfusion injury
Authors: Lin Xuehong , Xin Laiyun , Meng Xianqing , Chen Duo 
Published: December 2024

Objective:
Myocardial ischemia–reperfusion injury (MIRI) is a critical pathological basis for cardiovascular diseases. In recent years, the effect of ferroptosis on MIRI has attracted extensive attention. Vaspin, an adipose tissue-derived serine protease inhibitor, has multiple biological functions, including anti-inflammatory and antioxidant effects. This study aims to investigate the molecular mechanism by which vaspin alleviates MIRI by regulating hypoxia-inducible factor-1α (HIF-1α) and ferroptosis signaling pathways.

Material and Methods:
A mouse model of myocardial ischemia/reperfusion (I/R) and a hypoxia/reoxygenation (H/R) model was used to evaluate the protective effects of vaspin on MIRI. The mechanism by which ferroptosis is modulated by the vaspin/HIF-1α signaling pathway was investigated by constructing a vaspin overexpression adenoviral vector. Myocardial infarct size and histological changes were assessed using triphenyltetrazolium chloride and hematoxylin–eosin staining. Ferroptosis-related proteins were detected by Western blot assay, and apoptosis and reactive oxygen species levels were analyzed by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling. Iron content in myocardial tissue and cells was measured by enzyme-linked immunosorbent assay.

Results:
Myocardial I/R increased myocardial infarct size and serum lactate dehydrogenase (LDH) levels compared with the control group, indicating severe myocardial injury. Western blot results showed that MIRI reduced endogenous vaspin and HIF-1α levels and inhibited glutathione peroxidase 4. In vivo and in vitro vaspin overexpression treatment reduced infarct size, decreased LDH levels, inhibited ferroptosis pathway activity, and alleviated oxidative stress levels in myocardial tissues. In the H/R model, vaspin overexpression upregulated HIF-1α, inhibited ferroptosis markers, and reduced apoptosis and iron deposition. However, inhibiting HIF-1α reversed the cardioprotective and anti-ferroptotic effects of vaspin.

Conclusion:
Vaspin inhibits ferroptosis and upregulates the HIF-1α signaling pathway to mitigate myocardial I/R injury. The vaspin/HIF-1α pathway could be a potential target for MIRI prevention and treatment and offers fresh perspectives on ischemic heart disease management. Vaspin could be a novel cardioprotective agent that plays a significant role in the prevention and treatment of cardiovascular diseases.
Comparison of dexmedetomidine versus fentanyl-based total intravenous anesthesia technique on the requirement of propofol, brain relaxation, intracranial pressure, neuronal injury, and hemodynamic parameters in patients with acute traumatic subdural hematoma undergoing emergency craniotomy: A randomized controlled trial
Authors: Chandar Chinnarasan Vivek , Bidkar Prasanna Udupi , Swaminathan Srinivasan , Mani Manoranjitha , Vairappan Balasubramaniyan , Chatterjee Protiti , Joy Jerry Jame , Dey Ankita , Ramadurai Rajasekar , Gunasekaran Adethen 
Published: December 2024

Background:
Propofol is one of the most used intravenous anesthetic agents in traumatic brain injury (TBI) patients undergoing emergency neurosurgical procedures. Despite being efficacious, its administration is associated with dose-related adverse effects. The use of adjuvants along with propofol aids in limiting its consumption, thereby mitigating the side effects related to propofol usage. This study aims to compare the safety and efficacy of dexmedetomidine-propofol versus fentanyl-propofol-based total intravenous anesthesia (TIVA) in adult TBI patients.

Methods:
A hundred patients posted for emergency evacuation of acute subdural hematoma were enrolled, and they were randomized into two groups of 50 each. Propofol-based TIVA with a Schneider target-controlled infusion model was used for induction and maintenance. Patients in Group F received fentanyl, and those in Group D received dexmedetomidine infusions as adjuvants. Advanced hemodynamic parameters were monitored. Intracranial pressure (ICP) and brain relaxation were measured after dural opening. The mean propofol consumption, number of additional fentanyl boluses, and blood samples for S100b (a biomarker of neuronal injury) were also collected.

Results:
The mean propofol consumption in Group D (88.7 ± 31.8 μg/kg/min) was lower when compared to Group F (107.9 ± 34.6 μg/kg/min), (P = 0.005). The mean intraoperative fentanyl requirement and postoperative S100b were significantly reduced in Group D. Subdural ICPs and brain relaxation scores were comparable. Hemodynamic parameters were well maintained in both groups.

Conclusion:
In TBI, dexmedetomidine as an adjunct to propofol-based TIVA results in a greater reduction in total propofol consumption and intraoperative opioid requirements while maintaining hemodynamic stability when compared to fentanyl.
Devenir soi dans la troisième Inactuelle
Authors: Poignant-Le Goff Avrile 
Published: December 2024

Cet article se propose d’étudier en quoi la problématique du devenir soi, telle qu’elle émerge dans Schopenhauer éducateur, s’avère redevable de la figure de l’éducateur que Nietzsche y élabore. L’éducateur apparaît paradoxalement moins comme l’instigateur d’une formation de l’individu que comme le type d’homme dont l’éduqué lui-même doit assurer l’émergence future, en se mettant au service de la culture. La notion d’éducation de soi constitue alors le concept clé à partir duquel comprendre la vocation pédagogique nietzschéenne, en réponse au contexte de crise de l’éducation allemande : il lui faut s’éduquer lui-même pour pouvoir devenir à son tour éducateur.
Individualism against individuality: J. S. Mill and F. Nietzsche facing democracy as an anthropological turn
Authors: Dejardin Camille 
Published: December 2024

Tous deux lecteurs de Humboldt et de Tocqueville, également animés du souci proto-sociologique et même « physiologique » de scruter les interactions liant l’épanouissement de chaque individu et la bonne santé du corps social, John Stuart Mill et Friedrich Nietzsche partagent, à quelques décennies de distance, un diagnostic inquiet sur la mutation qui s’achève sous leurs yeux : le passage de ce que Louis Dumont a appelé le schème holiste au schème individualiste sous l’espèce de la démocratie, non comme forme institutionnelle mais comme nouvelle condition humaine marquée par l’égalisation. De fait, l’anthropologie démocratique consacrant l’individu comme fondement de la souveraineté et comme dépositaire de droits inaliénables se déploie pour la première fois sous le signe de l’égalité, à la fois juridique et représentationnelle, à la fois principe politique et « passion » psychologique. Pourtant, au moment où il se voit ainsi sacré, l’individu semble dissous. Atomisé, nivelé, déchu de toute perspective de grandeur ou de distinction (sinon purement matérielle), il se voit réduit à un ectoplasme juridique et économique. La réalisation voire la fortification de l’individualité sont-elles encore possibles ? Un individualisme de l’individualité est-il compatible avec les valeurs démocratiques ? Si oui, à quelles conditions ? Peut-on envisager une politique de l’individualité ? De Mill à Nietzsche, le regard critique se fait de plus en plus radical et subversif, et aussi plus incompatible avec le maintien de la démocratie.
Prioritisation of infectious diseases from a public health perspective: a multi-criteria decision analysis study, France, 2024
Authors: Ploin Dominique , Alexandre Mathilde , Ventelou Bruno , Che Didier , Coignard Bruno , Boulanger Nathalie , Burucoa Christophe , Caron François , Gallian Pierre , Hansmann Yves , Lienhardt Christian , Minodier Philippe , Partouche Henri , Revest Matthieu , Saidani Nadia , Salvat Gilles , Vignier Nicolas , Floreani Sylvie ,   Collaborators’ group, Henry Sabine , Pozzetto Bruno , Hoen Bruno 
Published: December 2024

Background
Within the International Health Regulations framework, the French High Council for Public Health was mandated in 2022 by health authorities to establish a list of priority infectious diseases for public health, surveillance and research in mainland and overseas France.

Aim
Our objective was to establish this list.

Methods
A multi-criteria decision analysis was used, as recommended by the European Centre for Disease Prevention and Control. A list of 95 entities (infectious diseases or groups of these, including the World Health Organization (WHO)-labelled ‘Disease X’) was established by 17 infectious disease experts. Ten criteria were defined to score entities: incidence rate, case fatality rate, potential for emergence and spread, impact on the individual, on society, on socially vulnerable groups, on the healthcare system, and need for new preventive tools, new curative therapies, and surveillance. Each criterion was assigned a relative weight by 77 multidisciplinary experts. For each entity, 98 physicians from various specialties rated each criterion against the entity, using a four-class Likert-type scale; the ratings were converted into numeric values with a nonlinear scale and respectively weighted to calculate the entity score.

Results
Fifteen entities were ranked as high-priorities, including Disease X and 14 known pathologies (e.g. haemorrhagic fevers, various respiratory viral infections, arboviral infections, multidrug-resistant bacterial infections, invasive meningococcal and pneumococcal diseases, prion diseases, rabies, and tuberculosis).

Conclusion
The priority entities agreed with those of the WHO in 2023; almost all were currently covered by the French surveillance and alert system. Repeating this analysis periodically would keep the list updated.
Antigenic changes in influenza A(H3N2) driven by genetic evolution: Insights from virological surveillance, EU/EEA, week 40/2023 to week 9/2024
Authors: Broberg Eeva K , Vukovikj Maja , Svartström Olov , Hasibra Iris , Riess Maximilian , Melidou Angeliki ,   Members of the ERLI-Net network
Published: December 2024

Background
During the 2023/24 influenza season in the European Union/European Economic Area (EU/EEA), influenza viruses A(H1N1)pdm09, A(H3N2) and B/Victoria viruses were co-circulating.

Aim
We aimed to describe the circulating influenza viruses by (sub)type, genetic clade, antigenic group and antiviral susceptibility in that season in the EU/EEA.

Methods
We collected surveillance data from EU/EEA countries through weekly submissions to The European Surveillance System (TESSy). Data were submitted in strain-based format for weeks 40/2023 to 9/2024.

Results
Twenty-nine EU/EEA countries reported 154,718 influenza virus detections (primary care sentinel and non-sentinel combined), of which 97% (150,692) were type A and 3% (4,026) were type B. Of the subtyped influenza A viruses, 30,463 (75%) were influenza A(H1)pdm09 and 10,174 (25%) were influenza A(H3). For 809 (20%) of the type B viruses, the lineage was determined; all were B/Victoria/2/87 lineage, and none were B/Yamagata/16/88 lineage. Genetic diversification of seasonal influenza viruses continued, and clade 5a.2a of A(H1N1)pdm09, 2a.3a.1 of A(H3N2) and V1A.3a.2 of B/Victoria-lineage viruses dominated. Of the A(H3N2) 2a.3a.1 viruses, 23% were antigenically distinct from the 2023/24 vaccine virus.

Conclusion
The 2023/24 influenza season was characterised by co-circulation of different influenza (sub)types, antigenically similar to the components recommended for the 2023/24 northern hemisphere vaccine, A/Victoria/4897/2022 (egg-based) and A/Wisconsin/67/2022 (cell culture- or recombinant-based). However, genetic diversification of the viruses continued. The World Health Organization’s vaccine recommendations for the northern hemisphere 2024/25 season were updated to include a new A(H3N2) component, while maintaining the current A(H1N1)pdm09 and B/Victoria components.
Redefiniendo el viaje: El papel emergente de la inteligencia artificial en el turismo
Authors: Flores Abrego Francisco , Guadarrama Atrizco Victor Hugo , Fragoso Manzo Dora Lidia 
Published: December 2024

La inteligencia artificial (IA) llega como una nueva oportunidad en diferentes áreas y sectores productivos. Para el caso del turismo se abren nuevas posibilidades y nuevos mercados. Esto impacta directamente en cómo se planifica, promociona y experimenta los viajes. En este artículo científico se examinará y deducirá el papel que juega la IA en el sector turístico, tanto a nivel internacional como en el contexto nacional. Para ello se presenta el contexto actual de las aplicaciones que tiene la IA, el uso de asistentes virtuales, así como también el uso de estas tecnologías por parte de algunos gobiernos. De igual forma se pretende abordar las implicaciones éticas y morales del uso de la misma, ya que al estar alimentados por grandes cantidades de datos, se pretende hacer una búsqueda del cómo se llevan a cabo la privacidad y el uso de datos para el aprendizaje de las IA. Se identificó que, dentro del contexto turístico, se presentan áreas de oportunidad que se pueden explotar para favorecer al turista y al prestador de servicios de diversas índoles. Finalmente indagar en la forma en la cual la IA se presenta como un sistema que se puede explotar de una forma que ayude al turista y al prestador a satisfacer sus variadas necesidades.
Lexicogrammatical Choices and Cognitive Patterns in Autism Spectrum Disorder: Insights from Self-Other Differentiation and Sense of Agency
Authors: Kato Sumi 
Published: December 2024

This study investigates key lexicogrammatical differences between individuals with Autism Spectrum Disorder (ASD) and non-ASD individuals, utilizing a corpus of spoken language from both ASD and non-ASD participants. Participants included 54 individuals with ASD (mean age = 20, SD = 6.83) and 70 non-ASD individuals (mean age = 21, SD = 6.72), all aged 15 and older. Framed within the Systemic Functional Linguistics model, the analysis focused on the TRANSITIVITY system, which organizes human experiences into six Process Types: Material, Mental, Relational, Behavioral, Verbal, and Existential. TRANSITIVITY system is essential for representing human experiences by categorizing them into processes, participants, and circumstantial elements. A t-test revealed a significant difference in the use of Existential Processes, with ASD individuals showing a higher frequency of expressions, such as aru (exist: inanimate) and iru (exist: animate), compared to non-ASD individuals. This suggests that individuals with ASD favor direct, concrete expressions of existence, which align with the ecological self—a cognitive orientation focused on immediate, physical interaction with the environment. This contrasts with more relational or socially mediated language, revealing distinct cognitive patterns in how ASD individuals perceive the world. The study examines the role of cognitive profiles in shaping lexicogrammatical choices, particularly in relation to self-other differentiation and agency. These findings underscore the link between cognitive functioning and language use, offering insights for ASD diagnosis. No prior studies have used lexicogrammatical choices as diagnostic markers for ASD, providing new perspectives on the relationship between cognition and language, with significant diagnostic implications.
Critical Analysis to Abu-Obiedas Speeches: Strength and Weak Points from a Translational Perspective
Authors: K Talafha Duaa , BaniYounes Zein Bassam , Khanam Afeera , Tahat Abdelrazzaq 
Published: December 2024

Speeches of Abu-Obieda constitute a cornerstone in the ongoing Al-Aqsa deluge war that embarked the agony between Israel and Hamas troops in Palestine. These speeches were presumably different from regular speeches of any regular army spokesmen in that Hamas is but a folk group that chooses to defend its freedom. This paper comes to analyze the weaknesses and strengths of these speeches as literature would barely cover them unless a paper by Alnwihe and Al-Abbas has touched upon a few points. The researchers disseminate CDA by Fairclough ,Aristotle's modes of persuasion and textuality theory by Beaugrande and Dressler to bring about these weaknesses and strengths. It is found that on the level of topics, speeches of Abu-Obieda bear real accusations based on featured logos prior to them while digression causes confusion to the English audiences. Linguistic devices, though show fewer weak points as far as Arabic discourse is concerned, the translation of these linguistic devices impedes the clarity of the message because of the cultural-specific terms and ‘enallage’ which are language devices peculiar to the Arabic language. Other linguistic devices such as cohesion and modality contribute to the power of the discourse in that they level up the cohesive and coherent force of the text. It is recommended that Abu-Obieda shall concentrate on reporting information more than adorning the text with Arabic stylistic devices that are difficult to be rendered into English by auto-generated translations.
A female with severe knee osteoarthritis and tibial pseudoarthrosis after stress fracture treated with knee endoprosthesis and tibial plating. Case report
Authors:   Department of Orthopedics and Traumatology, University of Medical Sciences, Poznań, Poland, Stępień Gabor , Żyliński Marcin ,   Department of Orthopedics and Traumatology, University of Medical Sciences, Poznań, Poland, Trzeciak Tomasz ,   Department of Orthopedics and Traumatology, University of Medical Sciences, Poznań, Poland
Published: December 2024

Stress fracture of the lower extremity is a significant cause of decreased mobility in orthopedic patients. With repetitive stress on the bone tissue of the lower extremities, stress fractures occur in 50% of the cases, primarily involving the tibia. This article presents a method of managing the pseudoarthrosis of the tibia resulting from a stress fracture of the shinbone of a patient with advanced degenerative changes in both knee joints. This article presents the case of a 69-year-old woman with advanced degenerative changes in both knee joints and a significant varus deformity of both lower limbs. She developed a stress fracture in the proximal part of the left tibia, resulting in the formation of pseudoarthrosis. The authors describe
a simultaneous left knee joint total knee replacement (TKR) procedure with limb axis correction using
a long tibial stem (tibial extension) passing through the pseudoarthrosis and rotational stabilization of the tibia with an osteo-plate.
Horses’ Self-recognition in the Mirror Test. New Approach
Authors: Ilmer Ida Aleksandra , Smoleń Tomasz 
Published: December 2024

This paper aims to present a new, modified mirror test procedure and to answer the question of whether the domestic horse (Equus caballus) is a self-conscious species in terms of reflexive consciousness. The new approach to the mirror test is characterised by a reduction in the animal’s exposure time to the mirror image, changes in the marker, and introduction of a control condition, which minimises the likelihood of false positive results. The sample includes 24 horses tested in two conditions. A quarter of the horses tested were able to detect a treat that was invisible to them, without seeing themselves in the mirror. This behaviour was interpreted as self-recognition. This proportion turned out to be statistically significantly different from the proportion expected in the null hypothesis, as shown by the McNemar test. In the light of the above results of the experiment and theoretical analysis of the characteristics of the species we draw a conclusion that the observed horses’ self-recognition is a likely mark of their self-consciousness.
Kontestasi Pemaknaan Ruwatan sebagai Alternatif Akikah (Studi Kasus di Desa Patrang Tengah Kabupaten Jember)
Authors: Yusnita Titis Rizka 
Published: December 2024

Siasat lokal yang mencampuradukkan ruwatan sebagai alternatif akikah menimbulkan kontestasi pemaknaan bagi masyarakat dan tokoh keagamaan setempat. Penelitian ini bertujuan mengidentifikasi latar belakang pelaksanaan ruwatan sebagai alternatif akikah dan bentuk tradisi ruwatan berdasarkan studi kasus yang terjadi di Desa Patrang Tengah, Kabupaten Jember.Data dalam penelitian ini berwujud hasil wawancara langsung terhadap dua tokoh agama (Islam) setempat. Data dianalisis berdasarkan teori budaya hibrid dan mimikri yang dikemukakan oleh Homi Bhabha. Tahap analisis data juga ditunjang dengan studi pustaka yang mengkaji hakikat ruwatan dan akikah dalamkelompok masyarakat tertentu. Tahap penyajian hasil analisis data menggunakan metode informal agar kontestasi pemaknaan ruwatan sebagai alternatif akikah yang terjadi di Desa Patrang Tengah dapat dijabarkan secara deskriptif dan mendalam. Hasil penelitian menunjukkan bahwa ruwatan sebagai budaya lokal yang dijalankan oleh kalangan masyarakat tertentu mengalami kontestasi pemaknaan yang cukup kompleks. Hal ini tidak terlepas dari dinamika pemahaman masyarakat, masalah ekonomi, dan waktu yang terus berjalan. Tradisi ruwatan sebagai produk kebudayaan dipengaruhi oleh persepsi masyarakat dalam memilah sudut pandang dan menyikapi tradisi yang berjalan. Budaya yang hidup berdampingan dengan konteks keagamaan berpotensi mengalami pergesekan jika tidak disikapi dengan tepat. Oleh sebab itu, konsep hibridisasi budaya ruwatan dengan akikah dihadirkan sebagai upaya masyarakat untuk menyelaraskan kondisi sosial dan ekonomi yang terjadi di kalangan tersebut.
Peran Pemandu Wisata Dalam Pengembangan Keberlanjutan Pariwisata Pasar Seni Ubud, Bali
Authors: Sitohang Lidya Lestari , Oktaviona Eka Rahma , Fa’addihillah Clarista Wahyu , Alfi Wawan , Yuviansyah Firdaus Adam , Hanifah Devi Fitriyah 
Published: December 2024

Kepuasan wisatawan dalam perjalanan wisata salah satunya dihasilkan oleh kualitas pelayanan melalui keterampilan pemandu wisata. Bali memiliki objek wisata menarik seperti Pasar Seni Ubud.Peran pemandu wisata atau tour guide dalam pengembangan objek wisatawan di Bali sangat penting. Studi ini bertujuan untuk mengetahui secara empiris bagaimana peran pemandu wisata dalam pengembangan objek pariwisata di Pasar Seni Ubud, Bali. Metode penelitian dalam penelitian ini adalah metode kualitatif.Teknik pengumpulan data berupa teknik triangulasi meliputi wawancara, observasi, catatan lapangan, dan studi kepustakaan. Teknik pemilhan nara sumber berdasarkan accidental sampling. Analisis dilakukan dengan menggunakan analisis tema. Hasil penelitian menujukkan bahwa peran pemandu wisata dalam pengembangan pariwisata di Bali terlihat dari kualitas karakter dan keterampilan berbahasa asing pemandu wisata. Peran pemandu wisata secara umum adalah penghubung antara destinasi wisata dan wisatawan. Peran pemandu wisata dalam pengembangan keberlanjutan pasar seni Ubud, Bali adalalah sebagai komunikator, pihak/agen yang menampung aspirasi, dan jembatan antara pemerintah dan wisatawan Kata Kunci : Pemandu Wisata, Peran Pemandu Wisata, Pengembangan Berkelanjutan Wisata