bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning and NLP For Knowledge Extraction from Laboratory Reports
Authors: Chen Branson , Dolatabadi Elham , Kwong Jeffrey , Azimaee Mahmoud 
Published: December 2020

IntroductionDue to the ever-growing volume and complexity of clinical data, it has become a tedious task to extract information from data for secondary uses such as decision support, quality assurance, and outcome analysis. Recently, there have been great advances in Natural Language Processing (NLP) approaches that automate knowledge extraction from clinical reports in order to save costs and improve efficiency.
Objectives/Approach​Our goal is the development of an NLP tool designed to automatically extract and encode clinical information from laboratory reports. This study describes and evaluates our NLP tool on provincial repositories of laboratory tests and results called Ontario Laboratory Information System (OLIS). OLIS is an electronic system that covers >200 labs and stores patients’ current and past test results as patients move through different areas of the healthcare system. Our NLP tool is a modular system of pipelined components including Named Entity Recognition module for extracting mentions of virus and test mentions and inference to combine extracted entities into a meaningful outcome.
Results​Initial analyses were conducted on a segment of OLIS related to laboratory tests for respiratory viruses. This data included over a million observations corresponding to ~100 Logical Observation Identifiers Names and Codes (LOINC), with >40,000 unique strings. The clinical text was cleaned, tokenized, and parsed using an in-house text algorithm that was continually refined with manual review from clinical experts. This data was then encoded as virus and test types to be used as a ground truth. The NLP tool was built on ground truth data and achieved an accuracy greater than 95%.
Conclusion/ImplicationsApproaches like these can be applied to many areas of health research that make use of clinical reports. Our methods, when optimized and validated, can be deployed into clinical systems to provide on-the-spot analysis of various laboratory reports.
Prevalence of Expanded Dengue Syndrome in Patients with Dengue Virus Infection at the Dr. Soetomo Hospital Surabaya in 2017 – 2018
Authors: Adissadah Avina Fimas , Aryati Aryati , Pusarawati Suhintam 
Published: December 2020

Dengue Fever (DF) or Dengue Hemorrhagic Fever (DHF) is one of the infectious diseases that attracts much global attention, especially Indonesia because it impacts the mortality rate of the people in the world if adequate treatment is not given. Expanded Dengue Syndrome (EDS) is a clinical manifestation involving several organs such as lungs, liver, kidney, heart, and brain-related to dengue infections, with or without plasma leakage. This study aimed to determine the prevalence of expanded dengue syndrome in patients with dengue virus infection at the Dr. Soetomo Hospital in 2017–2018. Based on its purpose, the sampling technique used in this study was the total sampling of patients with DVI who admitted to Dr. Soetomo Hospital Surabaya. Every pediatric and adult patient who met the criteria were included in this study until a certain period in 2017–2018. After the data collection, only thirty samples of EDS from the 196 sample data were collected. Thirty patients with expanded dengue syndrome had a manifestation of different organs. Such as: neurological, cardiac, respiratory system, gastro-hepatic, and kidneys. The laboratory test results showed that most platelet counts of 51,000 – 100,000 were found in seventeen patients, while the range of hemoglobin and hematocrit was normal. From a total of thirty samples of dengue virus infection patients with EDS, there were only eighteen patients who did a serological test. The most found serological results were (+/-) anti-dengue IgM and (+) anti-dengue IgG (40%).
Accuracy of magnetic resonance imaging for meniscal body tear in anterior cruciate ligament-deficient knees compared to anterior cruciate ligament-intact knee
Authors: Joshi Amit , Singh Nagmani , Basukala Bibek , Bista Rohit , Tripathi Navin , Pradhan Ishor 
Published: December 2020

Objectives:
This prospective case–control study was conducted with primary aim to compare the value of magnetic resonance imaging (MRI) in terms of accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for the detection of meniscal tear in anterior cruciate ligament (ACL)-deficient and ACL-intact groups. The secondary aim was to identify if the sensitivity and accuracy differ if the MRI is older than 3 months from the time of surgery.

Materials and Methods:
There were 255 patients enrolled into this study out of which 207 fulfilled the inclusion criteria. Among 207, 138 underwent surgery within 1 month of MRI, 30 had 1–3 months delay, and 39 cases underwent surgery more than 3 months after their MRI. Among 167 patients who underwent surgery within 3 months of MRI, 97 had ACL tear and 71 had intact ACL.

Results:
The overall sensitivity for lateral meniscus tear (68.2%) is significantly lower than the medial meniscus tear (92.9%). The sensitivity of MRI for medial meniscus tear in ACL-deficient knee is lower than ACL-intact knees (90% vs. 96.2%, P = 0.3). Similarly, the sensitivity is significantly lesser for lateral meniscus tear in ACL-deficient knee compared to ACL-intact knee (50% vs. 83.3%, P = 0.009). The sensitivity of MRI for both the lateral and medial meniscus tear decreased if the MRI performed 3 months before the surgery.

Conclusion:
Patients with ACL-deficient knee have to be counseled for intraoperative detection of lateral meniscus tear as the sensitivity of MRI for lateral meniscus tear in ACL-deficient group is low. Similarly, if the MRI is more than 3 months old from the time of surgery, we recommend to repeat the MRI as the sensitivity decreases significantly.
The search for candidate genes associated with hypermobile Ehlers-Danlos syndrome
Authors: Серебрякова Е.А. , Кадурина Т.И. , Лонишин Л.Р. , Аббакумова Л.Н. , Барбитов Ю.А. , Полев Д.Е. , Глотов О.С. , Глотов А.С. 
Published: December 2020

Представлены результаты молекулярно-генетического исследования пациентов с гипермобильным типом синдрома Элерса-Данло (гСЭД). Предложен возможный алгоритм верификации гСЭД и других наследуемых нарушений соединительной ткани с неуточнённой этиологией.
The results of a molecular genetic study of patients with a hypermobile type of Ehlers-Danlos syndrome (hEDS) are presented. A possible algorithm for verifying hEDS and other inherited disorders of connective tissue with unspecified etiology is proposed.
Study of genetic predisposition to osteoarthritis in women with connective tissue dysplasia from the Republic of Bashkortostan
Authors: Шаповалова Д.А. , Тюрин А.В. , Хусаинова Р.И. 
Published: December 2020

Остеоартрит (ОА) - наиболее распространенное многофакторное заболевание суставов. Одним из вероятных факторов риска развития ОА является недифференцированная дисплазия соединительной ткани (нДСТ) - генетически детерминированное нарушение структуры соединительной ткани, в том числе и в суставах. Вопрос о коморбидности ОА с нДСТ чрезвычайно актуален, и решение данной задачи будет способствовать разработке подходов ранней диагностики ОА в целях профилактики заболевания.
Osteoarthritis (OA) is a common multifactorial joint disease. Undifferentiated connective tissue dysplasia (uCTD) is a genetically determined lesion of the connective tissue structures, including joints, and it can be one of the factors, predisposing to development of OA. Solving the problem of comorbidity OA and uCTD signs will contribute to the early diagnosis and preventive of OA.
The role of collagen protein genes in the development of pelvic floor dysfunction in women
Authors: Вишневский Д.А. , Акуленко Л.В. , Касян Г.Р. , Тупикина Н.В. , Пушкарь Д.Ю. 
Published: December 2020

Коллагеновые волокна играют существенную роль в формировании связочного аппарата тазового дна. Однако, проведенные ранее исследования не дают точного ответа о роли полиморфных вариантов генов коллагена в дисфункции тазового дна. Целью настоящего исследования было определить ассоциацию однонуклеотидных полиморфизмов rs1800012 гена COL1A1, rs1800255 и rs1801184 гена COL3A1, rs2236479 гена COL18A1 и их сочетаний c пролапсом тазовых органов (ПТО) и стрессовым недержанием мочи (НМ). Группу исследования составили 150 пациенток с ПТО и/или НМ. В группу контроля вошли 100 пациенток без тазовой дисфункции. Пациентки были сопоставимы по возрасту и внешним факторам риска. Ассоциаций между полиморфизмами rs1800012 гена COL1A1, rs1800255 и rs1801184 гена COL3A1, rs2236479 гена COL18A1 и тазовой дисфункцией выявлено не было.
Collagen fibers play a significant role in the formation of the ligamentous apparatus of the pelvic floor. However, previous studies do not give an exact answer about the role of polymorphic variants of collagen genes on pelvic floor dysfunction. The aim of this study was to determine the association of single nucleotide polymorphisms rs1800012 of the COL1A1 gene, rs1800255 and rs1801184 of the COL3A1 gene, rs2236479 of the COL18A1 gene and their combinations with pelvic organ prolapse (POP) and stress urinary incontinence (SUI). The study group consisted of 150 patients with POP and/or SUI. The control group included 100 patients without pelvic dysfunction. Patients were comparable in age and external risk factors.All patients received a buccal epithelium for analysis. Sequencing was carried out by the Sanger method. Association between the rs1800012 polymorphisms of the COL1A1 gene, rs1800255 and rs1801184 of the COL3A1 gene, rs2236479 of the COL18A1 gene and pelvic dysfunction were not detected.
Assessment of genotoxic effects in one-and two-cell mouse embryos in vivo and in vitro using comet assay
Authors: Плигина К.Л. , Жанатаев А.К. , Анисина Е.А. , Даугель-Дауге Н.О. , Дурнев А.Д. 
Published: December 2020

Разработана методология оценки первичных повреждений ДНК в одно- и двухклеточных зародышах мышей методом ДНК-комет. Применимость разработанной методологии для оценки генотоксичности в зародышевых клетках in vivo и in vitro подтверждена в экспериментах с модельными генотоксикантами метилметансульфонатом, диоксидином, этопозидом и митомицином С.
A methodology for evaluating DNA damage in one - and two-cell mouse embryos using the comet assay has been developed. The applicability of the developed methodology for assessing genotoxicity in vivo and in vitro was confirmed in experiments with model genotoxicants - methyl methanesulfonate, dioxidine, etoposide and mitomycin C.
Deuterium oxide enhances the SOS response of Escherichia coli induced by bactericidal agents
Authors: Смирнова С.В. , Шапиро Т.Н. , Игонина Е.В. , Абилев С.К. 
Published: December 2020

Изучали генотоксическое действие бактерицидных средств диоксидина, фурацилина и налидиксовой кислоты на клетки дейтерированной культуры lux-биосенсора E.coli MG1655 (pColD::lux), люминесцирующего в результате активации промотора гена колицина colD в ответ на повреждение ДНК. Впервые показано, что оксид дейтерия (D2O) в концентрации 9% усиливает SOS-ответ, индуцированный исследуемыми лекарственными препаратами, в 1,6-2,8 раза в клетках E. coli.
We studied the genotoxic effect of bactericidal agents: dioxine, furaciline and nalidixic acid on cells of the deuterated culture lux-biosensor E. coli MG1655 (pColD::lux), which luminesces as a result of activation of the colicin gene promoter colD in response to DNA damage. For the first time, it was shown that deuterium oxide (D2O) at a concentration of 9% increases the SOS response by 1.6-2.8 times in E. coli cells induced by the studied drugs.
Antimutagenic activity and hepatoprotective effect of anti-radiation drugs
Authors: Сычева Л.П. , Рождественский Л.М. , Лисина Н.И. , Шлякова Т.Г. , Зорин В.В. 
Published: December 2020

Изучена антимутагенная активность противолучевых препаратов разного механизма действия: беталейкина, флагеллина, индралина и рибоксина в краткосрочных и хроническом экспериментах на мышах in vivo. Все препараты проявили антимутагенные свойства в клетках костного мозга, а также гепатопротекторное действие. Наибольший эффект при используемых условиях эксперимента отмечен для беталейкина и нового противолучевого препарата флагеллина.
The antimutagenic activity of anti-radiation drugs betaleukin, flagellin, indraline and riboxin with different mechanisms of action was studied in short-term and chronic experiments in mice in vivo. All drugs showed antimutagenic properties in bone marrow cells, as well as hepatoprotective effect. The greatest effect under the used experimental conditions was noted for betaleukin and the new anti-radiation drug flagellin.
PERKEMBANGAN INDUSTRI PERBANKAN SYARIAH DI INDONESIA : ANALISIS PELUANG DAN TANTANGAN
Authors: Werdi Apriyanti Hani 
Published: December 2020

ABSTRAK Industri Perbankan Syariah memiliki peran yang strategis dalam pembangunan ekonomi rakyat, berkontribusidalam melakukan transformasi perekonomian pada aktivitas ekonomi produktif, bernilai tambah dan inklusif.Akan tetapi di era financial digital dan tingginya persaingan industri jasa keuangan seperti sekarangini, perbankan syariah menghadapi berbagai tantangan, terutama berkaitan dengan rendahnyaTeknologi Informasi dan Komunikasi (ICT) dan keterbatasan modal. Oleh karena itu industri perbankan syariah harus memanfaatkan berbagai peluang ,yaitu dengan menyediakan inovasi produk berbasis Teknologi Informasi dan Komunikasi (ICT) untuk menyediakan beragam pilihan dan memperluas jangkauan pada masyarakat. Akan tetapi, sampai saat ini ivovasi produk perbankan syariah tersebut masih sangat terbatas.Selain itu, hal lain yang tidak kalah penting untuk mendukung perkembangan Perbankan Syariah di Indonesiaadalah dengan memanfaatkan peluang pertumbuhan ekonomi, dan meningkatkan ketersediaan dana banksyariah. Dengan memanfaatkan peluang tersebut, industri Perbankan syariah di Indonesia dapat berkembangdan memiliki dayasaing.
ANALISIS PENGARUH GOOD CORPORATE GOVERNANCE TERHADAP KINERJA PERUSAHAAN PERBANKAN DI INDONESIA
Authors: Listyawati Ika , Kristiana Ida 
Published: December 2020

Corporate governance is still a major problem during financial periods such as Indonesia. Especially, financial institutions have carried out reforms to improve goals and stakeholders. The purposeof this study is to measure corporate governance and in a banking environment that is specific to corporategovernance.The independent variables used in this study are ownership structures consisting of controllingshareholder ownership, foreign ownership, government ownership; the size of the board of directors; the sizeof the board of commissioners; independent commissioner; CAR. The sample of this study is a general bankingcompany located in Indonesia which is listed on the Indonesia Stock Exchange (BEI) for the period 2010-2014.This research data is derived from the annual report of the bank (annual report) for the period 20102014 whichis obtained fromthewebsiteof eachof the banks, theIndonesianBankingDirectory,Indonesian Capital Market Directory(ICMD).Theanalyticalmethodusedismultiple linear regression in accordance with the research objectives that analyzethe effect of independent variables on the dependentvariable. Thepurposivesamplingmethodisusedtodeterminethesampleofchoice.Fro this method,get26 samples of commercial banks.The results of the analysis found that Controlling Shareholder Ownership (OWN) andGovernment Ownership (GOV) showed a negative relationship not significant to banking performance.However, for Foreign Ownership (FOR), Board of Directors Size (BOD), Board of Commissioners Size(BOC), Proportion of Independent Commissioners (INDEP) shows a positive and significant relationship.Then for the variable Capital Adequacy Ratio (CAR) there is a significant negative relationship.
RELATIONSHIP AMONG MATERNAL, PRENATAL AND PREGNANCY OUTCOME IN RANGELI MUNICIPALITY OF NEPAL
Authors: Mahato Asmita , Shrestha Barsha 
Published: December 2020

Background: The incidence of pregnancy complications may be due to risk factors during pregnancy. Whether maternal parameters like age, gravida/ parity, gestational age, and fetal heart rate have any influence to the delivery outcome and newborn weight is a big quest. A young age at birth is more common in Nepal and carries a less social stigma, and hence enforces this study to understand the impact.
Objective and methodology: The objectives of this retrospective study were to evaluate the maternal and prenatal outcomes of pregnancies and the effects of the age of the pregnancy, gravida, gestational age, and newborn weight. Pregnant women giving birth in Rangeli Hospital, Morang (Nepal) in 2019 were retrospectively screened. Pregnant women of all age group were included in this study.
Results: Mean maternal age for delivery of child was 22.45 ±0.225 years. 41.9% of study subjects were primigravida (G1), while 58.1% were multi-gravida (G2-4). The mean age of primigravida is 20.57 ±0.025 years. Mean gestational week, fetal heart rate (FHR), and newborn weight were 38.18 ±0.11, 140.91 ±0.43, and 2870.65 ±26.13 g respectively. Almost one-third (32.1%) of the newborn were preterm babies. 20.9% of the newborn child was low birth weight. Spontaneous vaginal delivery was seen in 90.7% of the pregnancy while 7.9% had caesarean section.
Conclusion: A significant positive correlation was seen of age with gravida, parity, and newborn weight. Newborn weight was significantly related to gestational age. There is no significant difference between the mean maternal age of mother delivering preterm baby or term-baby. No significant difference in the mean age of the mother or the mean gestational duration between male and female children could be established. Significant mean differences were seen in the maternal age of LBW child and normal birth weight child.
Results of laparoscopic extravesical antireflux operation in vesicoureteral reflux in children
Authors: Dubrov V. I. , Strotsky A. V. 
Published: December 2020

The objective was to improve the results of surgical treatment of vesicoureteral reflux in children, using laparoscopic access. The prospective study was performed in 111 children (137 ureters) with the primary III–IV grade vesicoureteral reflux. The mean age was 34.7 months. The modified laparoscopic antireflux technique was performed on 73 children (91 ureters). We compared the perioperative complications and the medium-term outcome with a group of 38 children (46 ureters) who underwent classical laparoscopic extravesical reimplantation.3 In the modified group, the mean surgery time was 109.8 ± 31.5 minutes for unilateral cases and 176.5 ± 47.6 minutes for bilateral cases; in the classical group, it was 118.6 ± 34.3 and 209.5 ± 51.2 minutes respectively (p > 0.05). Postoperative vesicoureteral reflux had 2 (2.7 %) patients in the main group and 8 (21.1 %) children in the control group (p = 0.002). There was no ureteral obstruction in the both groups. The success rate for ureters was 97.8 % with modified technique versus 82.6 % after classical laparoscopic reimplantation (p = 0.003). Laparoscopic extravesical ureteral reimplantation is a safe and effective surgical procedure. The modified technique may improve the surgical treatment results.
Role of calcitriol in modulating of placental dysfunction in pregnant women with chronic kidney disease
Authors: Manasova G. S. , Didenkul N. V. , Mnich L. V. , Chumak Z. V. , Kuzmin N. V. 
Published: December 2020

The pleiotropic effects of vitamin D (VD), whose active form is synthesized in the kidneys, play a certain role both in forming and functioning the feto-placental system, including various pregnancy complications. The aim of the study was to evaluate the vitamin D status in pregnant women with placental dysfunction (PD) and chronic inflammatory kidney disease (CIKD). During 24–34 pregnancy weeks, 56 pregnant women with PD were examined (main group ‒ I); 24 patients (42.85 %) had chronic pyelonephritis (group IA). The control group (group II) had 31 conditionally healthy pregnant women. The total VD level in the blood was determined by ELISA; in addition to the general clinical standard examination, the urine also underwent bacteriological examination. The VD mean level in pregnant women with PD and CIKD was significantly lower than that in the control group (31.08 ± 7.2 and 45.42 ± 9.67 ng/ml (p <0.01)). Only 33.33 % of pregnant women in group IA had a VD optimum, as well as 93.55 % (p < 0.01) in the control group and 17.86 % in group I. 8.33 % of pregnant women had a VD deficiency in group IA (RR = 2.09; CI 95 % ‒ 1.8‒2.42). The patients with a VD-deficiency were absent in the control group. 58.33 % of women in group ІА had a suboptimal VD level and 6.45% in the control group (RR = 3.57; CI 95 % ‒ 1.62‒7.88). Bacteriuria was observed in all pregnant women with a VD-deficient or suboptimal level. At the optimum VD level, bacteriuria was diagnosed twice less (χ2 = 66.67; p <0.01). In patients with an inadequate VD level, CIKD was diagnosed 3.8 times more (RR = 3.57; CI 95 % ‒ 1.62‒7.88). 494 Proceedings of the National Academy of Sciences of Belarus. Medical series, 2020, vol. 17, no. 4, pp. 493–499 A significantly calcitriol reduction in pregnant women with placental dysfunction suggests that the deficiency or the suboptimal level of vitamin D and inflammatory kidney diseases may be the interdependent processes that play a decisive role in the formation of placental dysfunction.
Cluster Analysis and SSR (Simple Sequence Repeats) Primers Selection for Aluminium Tolerance on Hot Pepper
Authors: Herison Catur , Rustikawati  , Meita Ria , Hasanudin  
Published: December 2020

Perakitan varietas unggul cabai merah toleran Al (Aluminium) merupakan solusi terbaik untuk mengatasi persoalan rendahnya produkvitas cabai di lahan kering masam. Identifikasi tetua toleran dan marka SSR (Simple Sequence Repeats) sangat bermanfaat dalam meningkatkan efektifitas program pemuliaan tanaman untuk merakit varietas toleran terhadap cekaman aluminium. Seleksi primer SSR adalah bagian awal yang penting dalam pengembangan marka molekuler tersebut. Penelitian bertujuan untuk menentukan kelompok genotipe toleran alumunium dan menentukan primer prospektif dalam pengembangan marka SSR untuk sifat toleran terhadap Al pada tanaman cabai. Evaluasi tingkat toleransi 27 genotipe cabai terhadap cekaman aluminium dilakukan menggunakan hidroponik sistem sumbu dengan larutan hara AB mix ditambah 500 ppm AlCl3.6H2O. Tahap selanjutnya adalah menguji 20 primer SSR dalam mengamplifikasi DNA genom cabai toleran dan peka yang mewakili. Hasil analisis cluster sifat toleransi terhadap 27 genotipe cabai menghasilkan 7 kelompok tingkat toleransi terhadap aluminium. Individu PBC396 dan PBC518 adalah genotipe yang sangat toleran terhadap cekaman aluminium yang unik sehingga keduanya sangat baik digunakan sebagai tetua dalam pengembangan cabai toleran aluminium. Primer SSR yang potensial menghasilkan marka polimorfik untuk sifat toleran terhadap cekaman aluminium pada cabai adalah TMS7 dan CAMS358. Primer tersebut selanjutnya harus diuji pada mapping population untuk menentukan pita yang dapat digunakan sebagai penanda toleransi terhadap aluminium.
Kata kunci: Capsicum annuum, NTSYS, sidik gerombol, tenggang masam
La participation des patients âgés à la relation de soins en question(s) !
Authors: Bonnemaizon Audrey , Amine Abdelmajid , Josion-Portail Margaret 
Published: December 2020

Cet article propose un aménagement de laService Dominant Logic(SDL) dans le cas des relations de service avec les publics vulnérables sur la base d’une étude qualitative menée dans un service gériatrique. Cette étude révèle d’une part, des pratiques de soins régies par des représentations du patient âgé « déficient » (intégration de ressources externes au patient), d’autre part, des pratiques de soins irriguées par des représentations du patient âgé « en capacité » (intégration de ressources internes au patient). Ces pratiques suggèrent des rôles différenciés endossés par les soignants traduisant une (non) participation des patients.