bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of noise data into building information model (BIM) to reduce noise in the environment and at workplace
Authors: Butorina Marina , Drozdova Lyudmila , Kuklin Denis , Sharkov Alexander , Aref’ev Konstantin , Sopozhnikov Sergey , Topazh Grigoriy , Lyamaev Boris , Nagornyy Vladimir , Simonov Anatoliy , Muhametova Liliya 
Published: November 2019

Abstract
Noise mapping is the best way to present information on the acoustic pollution. To design noise protection measures, authors use modern software package SoundPLAN, which is based on the up-to-date normative documentation and scientific researches. The program allows importing the results of calculations to Autodesk tools. Improving the efficiency of the noise protection design process is executed through the implementation of building information modeling (BIM). Data exchange between SoundPLAN, AutoCAD 3D or Revit and Navisworks is used in the development of building information model. In the article we present a new approach to noise reduction through implementation of noise data into the overall information model of the infrastructure or building project. BIM helps to track the collision of calculated noise levels with residential buildings, protected premises and workplaces. It lays a basis for the sound proof allocation of workplaces and development of protection measures. BIM also serves as a support tool for the design process of sound protection barriers, since it helps to avoid interconnection of noise barriers basement with engineering networks or paste a barrier in the proper place to provide its efficiency.
Cannabis and residential groundwater pumping impacts on streamflow and ecosystems in Northern California
Authors: Zipper Samuel C , Carah Jennifer K , Dillis Christopher , Gleeson Tom , Kerr Ben , Rohde Melissa M , Howard Jeanette K , Zimmerman Julie K H 
Published: November 2019

Abstract
Cannabis is an emerging agricultural frontier, but due to its quasi-legal status its environmental impacts are poorly understood. Where cannabis is irrigated by groundwater, pumping can lead to streamflow depletion in surrounding streams which may impair other water users or aquatic ecosystems. Here, we investigate the impacts of groundwater pumping for cannabis irrigation at the scale of the watershed, the individual well, and the stream segment, and contextualize by comparing with residential groundwater use. Combining mapped cannabis cultivation and residential structure locations with grower reports of irrigation water sources, we develop distributed estimates of groundwater pumping and associated streamflow depletion caused by cannabis and residential users within the Navarro River Watershed in Northern California (USA). An estimated 73% of cannabis cultivation sites and 92% of residential structures in the watershed rely on groundwater, and groundwater abstraction leads to streamflow depletion during late summer when groundwater is a critical source of baseflow to ecologically important streams. However, streamflow depletion caused by cannabis cultivation is dwarfed by the impacts of residential use, which causes >5 times as much streamflow depletion and is concentrated close to ecologically important stream segments. Focusing on cannabis, a small number of wells (<25%) cause a disproportionate amount of depletion (>50%), and significant predictors for impacts of a well are the annual pumping rate, the distance to the closest stream, and the transmissivity between the well and the stream. Streamflow depletion increases nonlinearly when pumping occurs within 1.2 km of streams, and most cannabis and residential groundwater use is within this critical distance. Given the rapid increase in cannabis cultivation, these results indicate that potential streamflow depletion from groundwater irrigation of cannabis is a current and future concern, and will be superimposed on top of significant depletion already occurring due to residential use in the region studied.
Daily fluctuations in pollination effectiveness explain higher efficiency of native over exotic bees in Lepechinia floribunda (Lamiaceae)
Authors: Baranzelli Matias Cristian , Benitez-Vieyra Santiago , Glinos Evangelina , Trenchi Alejandra , Córdoba Silvina , Camina Julia , Ashworth Lorena , Sérsic Alicia Noemi , Cocucci Andrea Aristides , Fornoni Juan 
Published: November 2019

AbstractBackgroundDespite Stebbins’ principle of the most efficient pollinator being proposed decades ago, the most important pollinators are still mainly identified using the frequency of visits to flowers. This shortcoming results in a gap between the characterization of the flower visitors of a plant species and a reliable estimation of the plant fitness consequences of the mutualistic interaction. The performance of a mutualistic visitor depends on its abundance, behaviour, effectiveness (pollen removal and deposition per unit time) and efficiency (seed set per unit time) conditioned by the temporal matching between pollinator activity and temporal patterns of maturation of the sexual functions of flowers. Although there have been recent attempts to provide a conceptual and methodological framework to characterize pollinators’ performance, few have combined all key elements of visitors and plants to provide an accurate estimation of pollinators’ performance under natural conditions.MethodsWe complement information on the flower biology and mating system of the sub-shrub Lepechinia floribunda (Lamiaceae) to provide a daily quantitative estimation of performance (effectiveness and efficiency) of the more abundant pollinators, i.e. native bumble-bees (Bombus spp.) and leafcutter bees (Megachile sp.), and the exotic honey-bee (Apis mellifera).Key ResultsUnlike honey-bees or leafcutter bees, native bumble-bees matched the daily pattern of nectar production and stigma receptivity, and showed higher effectiveness and efficiency. Despite the overabundance of honey-bees, visits occurred mainly when stigmas were not receptive, thus reducing the honey-bees’ overall performance.ConclusionsBumble-bees appear to be the most important pollinators and potential historical mediators of reproductive trait evolution in L. floribunda. Because the production of seeds by bumble-bees involved fewer pollen grains for plants and less investment in floral display than honey-bees, contemporary and expected changes in pollinator abundance may affect future L. floribunda floral evolution. If bumble-bees were to be further displaced by anthropogenic disturbance or by competition with honey-bees, their lower efficiency will select for a larger floral display increasing reproductive costs. This scenario may also impose selection to reduce dichogamy to match honey-bee foraging activity.
The role of nectar traits and nectary morphoanatomy in the plant-pollinator interaction between Billbergia distachia (Bromeliaceae) and the hermit Phaethornis eurynome (Trochilidae)
Authors: Zambon Vivian , Agostini Kayna , Nepi Massimo , Rossi Mônica Lanzoni , Martinelli Adriana Pinheiro , Sazima Marlies 
Published: November 2019

Abstract
Nectar production dynamics can show inter- and intraspecific variation, which can be associated with environmental and ecological factors and with the ultrastructural diversity of the floral nectary. In this context, we recorded nectar production dynamics from a morphofunctional perspective using the hummingbird-pollinated Billbergia distachia (Bromeliaceae). The scale-throated hermit Phaethornis eurynome was the only floral visitor observed, indicating a specialized pollination system. Nectar production showed significant differences between day and night, and the periods of major pollinator activity and nectar secretion were synchronous. The ultrastructural features of the nectary showed some evidence of nectar reabsorption in flowers at night, and it can be inferred that this process may be a key factor in the nocturnal pause in nectar production. In this way, nectary morphoanatomy, nectar traits and an energy-saving mechanism through nectar reabsorption contribute to the well-established relationship between B. distachia and P. eurynome.
Knockdown of ISOC1 inhibits the proliferation and migration and induces the apoptosis of colon cancer cells through the AKT/GSK-3β pathway
Authors: Gao Bo , Zhao Lianmei , Wang Feifei , Bai Hanyu , Li Jing , Li Meng , Hu Xuhua , Cao Jian , Wang Guiying 
Published: November 2019

Abstract
Isochorismatase domain-containing 1 (ISOC1) is a coding gene that contains an isochorismatase domain. The precise functions of ISOC1 in humans have not been clarified; however, studies have speculated that it may be involved in unknown metabolic pathways. Currently, it is reported that ISOC1 is associated with breast cancer. In this research, the aim is to investigate the critical role of ISOC1 in colorectal cancer (CRC) and to explore its biological function and mechanism in colon cancer cells. In 106 paired clinical samples, we found that the levels of ISOC1 expression were widely increased in cancer tissues compared with matched adjacent non-tumor tissues and that increased expression of ISOC1 was significantly associated with tumor size, tumor invasion, local lymph node metastasis and Tumor, Node and Metastasis (TNM) stage. Moreover, higher expression levels of ISOC1 were correlated with shorter disease-free survival in patients 2 years after surgery. In vitro, ISOC1 knockdown inhibited the proliferation and migration and induced the apoptosis of colon cancer cells, and in vivo, the xenograft tumors were also inhibited by ISOC1 silencing. We also used MTS, Transwell and cell apoptosis assays to confirm that ISOC1 plays a critical role in regulating the biological functions of colon cancer cells through the AKT/GSK-3β pathway. Additionally, the results of confocal microscopy and western blot analysis indicated that ISOC1 knockdown could promote p-STAT1 translocation to the nucleus.
Osteopontin drives KRAS-mutant lung adenocarcinoma
Authors: Giopanou Ioanna , Kanellakis Nikolaos I , Giannou Anastasios D , Lilis Ioannis , Marazioti Antonia , Spella Magda , Papaleonidopoulos Vassilios , Simoes Davina C M , Zazara Dimitra E , Agalioti Theodora , Moschos Charalampos , Magkouta Sophia , Kalomenidis Ioannis , Panoutsakopoulou Vily , Lamort Anne-Sophie , Stathopoulos Georgios T , Psallidas Ioannis 
Published: November 2019

AbstractIncreased expression of osteopontin (secreted phosphoprotein 1, SPP1) is associated with aggressive human lung adenocarcinoma (LADC), but its function remains unknown. Our aim was to determine the role of SPP1 in smoking-induced LADC. We combined mouse models of tobacco carcinogen-induced LADC, of deficiency of endogenous Spp1 alleles, and of adoptive pulmonary macrophage reconstitution to map the expression of SPP1 and its receptors and determine its impact during carcinogenesis. Co-expression of Spp1 and mutant KrasG12C in benign cells was employed to investigate SPP1/KRAS interactions in oncogenesis. Finally, intratracheal adenovirus encoding Cre recombinase was delivered to LSL.KRASG12D mice lacking endogenous or overexpressing transgenic Spp1 alleles. SPP1 was overexpressed in experimental and human LADC and portended poor survival. In response to two different smoke carcinogens, Spp1-deficient mice developed fewer and smaller LADC with decreased cellular survival and angiogenesis. Both lung epithelial- and macrophage-secreted SPP1 drove tumor-associated inflammation, while epithelial SPP1 promoted early tumorigenesis by fostering the survival of KRAS-mutated cells. Finally, loss and overexpression of Spp1 was, respectively, protective and deleterious for mice harboring KRASG12D-driven LADC. Our data support that SPP1 is functionally involved in early stages of airway epithelial carcinogenesis driven by smoking and mutant KRAS and may present an important therapeutic target.
Modelling and analysis of tagging networks in Stack Exchange communities
Authors: Fu Xiang , Yu Shangdi , Benson Austin R 
Published: November 2019

AbstractLarge Question-and-Answer (Q&A) platforms support diverse knowledge curation on the Web. While researchers have studied user behaviour on such platforms in a variety of contexts, there is relatively little insight into important by-products of user behaviour that also encode knowledge. Here, we analyse and model the macroscopic structure of tags applied by users to annotate and catalogue questions, using a collection of 168 Stack Exchange websites that span a diversity of sizes and topics. We study the distribution of tag frequencies and also the structure of ‘co-tagging’ networks where nodes are tags and links connect tags that have been applied to the same question. We find striking similarity in tagging structure across Stack Exchange communities, even though each community evolves independently (albeit under similar guidelines). Our findings thus provide evidence that social tagging behaviour is largely driven by the Stack Exchange platform itself and not by the individual Stack Exchange communities. We also develop a simple generative model that creates random bipartite graphs of tags and questions. Our model accounts for the tag frequency distribution but does not explicitly account for co-tagging correlations. Even under these constraints, we demonstrate empirically and theoretically that our model can reproduce a number of the statistical properties that characterize co-tagging networks.
Insight into the Productivity, Cost and Soil Impacts of Cable-assisted Harvester-forwarder Thinning in Western Oregon
Authors: Green Preston Q , Chung Woodam , Leshchinsky Ben , Belart Francisca , Sessions John , Fitzgerald Stephen A , Wimer Jeffrey A , Cushing Tamara , Garland John J 
Published: November 2019

AbstractCable-assisted (or tethered) mechanized harvesting has recently been introduced to the Pacific Northwest of the United States, and is rapidly being adopted by the forest industry. However, potential environmental impacts, productivity and cost of the new harvesting systems have not been well-assessed. This study aims to examine the effects of cable assistance on soil compaction, system productivity and cost through a field-based experiment. A harvester-forwarder system was used to thin a harvest unit on dry soils in western Oregon, with and without cable-assistance. We conducted a detailed time study during operations and collected soil measurements before and after machine passes. Machine productivity ranged from 28.75 to 92.36 m3 per scheduled machine hour, with resulting unit costs for untethered and tethered systems ranging from $13.19 to $18.13/m3. Our results showed reduced soil impacts in both extent and degree of soil compaction when cable assistance was employed. The reduced extent of soil impacts is attributed to a reduction in track wander owing to the operative tensions of the tether cable, and the smaller increase in soil density appears to be attributed to combined effects of initially denser soil conditions and reduced shear displacement as a result of cable-assistance.
Interventions Promoting Physical Activity Among Older Adults: A Systematic Review and Meta-Analysis
Authors: Grande Guilherme D , Oliveira Crystian B , Morelhão Priscila K , Sherrington Catherine , Tiedemann Anne , Pinto Rafael Z , Franco Marcia R 
Published: November 2019

Abstract

Background and Objectives
Frequent participation in physical activity (PA) has benefits across the lifespan but is particularly important for older adults. PA levels are either measured by objective or self-reported survey methods. Objective PA measurement is used to increase accuracy. This systematic review investigated the effect of physical activity-based interventions on objectively measured PA levels among community-dwelling adults aged 60 years and older.

Research Design and Methods
Literature searches were conducted in five electronic databases and four clinical trial registries. Randomized controlled trials investigating the effect of physical activity–based interventions on objectively measured PA levels (e.g., accelerometers or pedometers) in community-dwelling adults aged 60 years and older compared with no/minimal intervention were considered eligible. Data were pooled using the most conservative estimates reported from each study using the standardized mean difference (SMD). Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the overall quality of the evidence.

Results
Fourteen published trials and 3 ongoing trials were identified. There were significant effects favoring physical activity–based interventions compared with minimal intervention at short-term (less than or equal to 3 months) (SMD: 0.30, 95% CI: 0.17 to 0.43) and intermediate-term (more than 3 months and less than 12 months; SMD: 0.27, 95% CI: 0.06 to 0.49) follow-ups. The quality of evidence was moderate according to GRADE (downgraded for risk of bias).

Discussion and Implications
Our findings suggest that physical activity–based interventions may increase objectively measured PA levels in community-dwelling older adults. Further studies are still needed to identify the optimal dose, intensity, and mode of delivery of physical activity–based interventions.
Gaussian process models—II. Lessons for discrete inversion
Authors: Valentine Andrew P , Sambridge Malcolm 
Published: November 2019

Summary
By starting from a general framework for probabilistic continuous inversion (developed in Part I) and introducing discrete basis functions, we obtain the well-known algorithms for probabilistic least-squares inversion set out by Tarantola & Valette (1982). In doing so, we establish a direct equivalence between the spatial covariance function that must be specified in continuous inversion, and the combination of basis functions and prior covariance matrix that must be chosen for discretised inversion. We show that the common choice of Tikhonov regularisation ($\mathbf {C_m^{-1}} = \sigma ^2\mathbf {I}$) arises from a delta-function spatial covariance, and that this lies behind many of the artefacts commonly associated with discretised inversion. We show that other choices of spatial covariance function can be used to generate regularisation matrices yielding substantially better results, and permitting localisation of features even if global basis functions are employed. We are also able to offer a straightforward explanation for the spectral leakage problem identified by Trampert & Snieder (1996).
Subaltern Histories
Authors: Schwarz Bill 
Published: November 2019

Abstract
Bill Schwarz reviews the work of the South Asian Subaltern Studies historians of the 1980s and 1990s. Formed in the afterlives of the British Communist Historians Group of the 1940s to the 1970s, the Subaltern Studies collective determined to understand what that inherited historiographical paradigm would look like if the question of colonialism were located at its core. He asks also why it was that the History Workshop approaches to history, which began from a similar starting point and sought to recast how history was conceived – emphasizing less colonialism than gender/sexuality – were relatively deaf to the kindred historical project, when each approach was grappling with similar conceptual issues.
Totally endoscopic aortic valve replacement via an anterolateral approach using a standard prosthesis
Authors: Tokoro Masayoshi , Sawaki Sadanari , Ozeki Takahiro , Orii Mamoru , Usui Akihiko , Ito Toshiaki 
Published: November 2019

Abstract

OBJECTIVES
Totally endoscopic aortic valve replacement (AVR) is still a challenging operation, and only a few series reports exist in the literature. The purposes of this study were to establish a method for endoscopic AVR and evaluate its initial results.

METHODS
A total of 47 patients (median age 76 years, 17 men) underwent endoscopic AVR. The main wound was created in the right anterolateral 4th intercostal space through a 4-cm skin incision. No rib spreader was used. A 3-dimensional endoscope was inserted at the midaxillary line. A 5.5-mm trocar was inserted in the 3rd intercostal space, thus creating a 3-port setting similar to that used for endoscopic mitral valve surgery. A standard prosthesis was used, and the sutures were tied using a knot pusher. Results were compared with those of 157 patients who underwent right transaxillary AVR with direct vision plus endoscopic assist.

RESULTS
Patient backgrounds did not differ significantly between the 2 groups. No deaths occurred in the entire series. There was no conversion to thoracotomy or sternotomy in the endoscopic AVR group. The complication rate did not differ significantly between the 2 groups. The total operating time was significantly shorter in endoscopic AVR (188–206 min); the cardiopulmonary bypass time (130–128 min) and the cross-clamp time (90–95 min) did not differ significantly (median, endoscopic AVR, right transaxillary AVR). Two patients underwent endoscopic double-valve (aortic and mitral) surgery under the same conditions.

CONCLUSIONS
Endoscopic AVR was possible through 3 ports created in the right anterolateral chest, similar to the procedure for endoscopic mitral valve surgery. By adopting a common approach for both the aortic and the mitral valve operations, endoscopic double-valve surgery can be performed seamlessly.
Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health
Authors: Yang Qian , Millard Louise A C , Davey Smith George 
Published: November 2019

Abstract

Background
A lack of genetic data across generations makes transgenerational Mendelian randomization (MR) difficult. We used UK Biobank and a novel proxy gene-by-environment MR to investigate effects of maternal smoking heaviness in pregnancy on offspring health, using participants’ (generation one: G1) genotype (rs16969968 in CHRNA5) as a proxy for their mothers’ (G0) genotype.

Methods
We validated this approach by replicating an established effect of maternal smoking heaviness on offspring birthweight. Then we applied this approach to explore effects of maternal (G0) smoking heaviness on offspring (G1) later life outcomes and on birthweight of G1 women’s children (G2).

Results
Each additional smoking-increasing allele in offspring (G1) was associated with a 0.018 [95% confidence interval (CI): -0.026, -0.009] kg lower G1 birthweight in maternal (G0) smoking stratum, but no meaningful effect (-0.002 kg; 95% CI: -0.008, 0.003) in maternal non-smoking stratum (interaction P-value = 0.004). The differences in associations of rs16969968 with grandchild’s (G2) birthweight between grandmothers (G0) who did, versus did not, smoke were heterogeneous (interaction P-value = 0.042) among mothers (G1) who did (-0.020 kg/allele; 95% CI: -0.044, 0.003), versus did not (0.007 kg/allele; 95% CI: -0.005, 0.020), smoke in pregnancy.

Conclusions
Our study demonstrated how offspring genotype can be used to proxy for the mother’s genotype in gene-by-environment MR. We confirmed the causal effect of maternal (G0) smoking on offspring (G1) birthweight, but found little evidence of an effect on G1 longer-term health outcomes. For grandchild’s (G2) birthweight, the effect of grandmother’s (G0) smoking heaviness in pregnancy may be modulated by maternal (G1) smoking status in pregnancy.