bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of clopidogrel vs. prasugrel vs. ticagrelor on endothelial function, inflammatory parameters, and platelet function in patients with acute coronary syndrome undergoing coronary artery stenting: a randomized, blinded, parallel study
Authors: Schnorbus Boris , Daiber Andreas , Jurk Kerstin , Warnke Silke , Koenig Jochem , Lackner Karl J , Münzel Thomas , Gori Tommaso 
Published: December 2019

Abstract

Aims
In a randomized, parallel, blinded study, we investigate the impact of clopidogrel, prasugrel, or ticagrelor on peripheral endothelial function in patients undergoing stenting for an acute coronary syndrome.

Methods and results
The primary endpoint of the study was the change in endothelium-dependent flow-mediated dilation (FMD) following stenting. A total of 90 patients (age 62 ± 9 years, 81 males, 22 diabetics, 49 non-ST elevation myocardial infarctions) were enrolled. There were no significant differences among groups in any clinical parameter. Acutely before stenting, all three drugs improved FMD without differences between groups (P = 0.73). Stenting blunted FMD in the clopidogrel and ticagrelor group (both P &lt; 0.01), but not in the prasugrel group. During follow-up, prasugrel was superior to clopidogrel [mean difference 2.13, 95% confidence interval (CI) 0.68–3.58; P = 0.0047] and ticagrelor (mean difference 1.57, 95% CI 0.31–2.83; P = 0.0155), but this difference was limited to patients who received the study therapy 2 h before stenting. Ticagrelor was not significantly superior to clopidogrel (mean difference 0.55, 95% CI −0.73 to 1.82; P = 0.39). No significant differences were seen among groups for low-flow-mediated dilation. Plasma interleukin (IL)-6 (P = 0.02 and P = 0.01, respectively) and platelet aggregation reactivity in response to adenosine diphosphate (P = 0.002 and P = 0.035) were lower in the prasugrel compared to clopidogrel and ticagrelor group.

Conclusion
As compared to ticagrelor and clopidogrel, therapy with prasugrel in patients undergoing stenting for an acute coronary syndrome is associated with improved endothelial function, stronger platelet inhibition, and reduced IL-6 levels, all of which may have prognostic implications. This effect was lost in patients who received the study medication immediately after stenting.

EUDRACT-No
2011-005305-73
Influence of baseline QRS on the left ventricular ejection fraction recovery after frequent premature ventricular complex ablation
Authors: Penela Diego , Jáuregui Beatriz , Fernández-Armenta Juan , Aguinaga Luis , Tercedor Luis , Ordóñez Augusto , Acosta Juan , Bisbal Felipe , Vassanelli Francesca , Teres Cheryl , Aceña Marta , Martí-Almor Julio , De Sensi Francesco , Vatasescu Radu , Borràs Roger , Sánchez Millán Pablo , Soto-Iglesias David , Oller Martínez Guillermo , Carballo Julio , Berruezo Antonio 
Published: December 2019

Abstract

Aims
Frequent premature ventricular complexes (PVCs) can induce or worsen left ventricular systolic dysfunction. We aimed to investigate the influence of the baseline QRS in the response after PVC ablation in patients with depressed left ventricular ejection fraction (LVEF).

Methods and results
Two hundred and fifteen [59 ± 13 years old, 152 (71%) men] consecutive patients with left ventricular (LV) systolic dysfunction and frequent PVCs referred for ablation were included and followed-up for 12 months. Echocardiographic response was defined as an improvement of at least five absolute points in LVEF. Clinical, electrocardiogram, and electrophysiological characteristics were analysed. Mean baseline QRS duration was 110 ms [97–140]. Premature ventricular complex burden significantly decreased after ablation from 23% [16–33] at baseline to 1% [0–8] at 12 months, P &lt; 0.001. Mean PVC burden reduction was 18 [8–30] points. There was a significant improvement of LVEF from 35% [29–40] at baseline to 44% [35–55] at 12 months, P &lt; 0.001. One hundred and thirty (61%) patients were considered as echocardiographic responders. Baseline QRS duration (ms) [odds ratio (OR) 0.98 (0.97–0.99), P = 0.01] was an independent predictor of echocardiographic response. Mean LVEF improvement was 16 [10–21] points when the baseline QRS duration was &lt;90 ms; 12 [4–20] when it was 90–110 ms; 5 [0–15] when it was 110 ± 130 ms; and 0 [0–6] points when it was &gt;130 ms.

Conclusions
In patients with LV systolic dysfunction, intrinsic QRS duration is inversely related to the probability and the degree of echocardiographic response after frequent PVC ablation. Patients with a QRS duration &gt;130 ms at baseline have the poorer response after ablation.
Differences in urban forest visitor preferences for emerald ash borer-impacted areas
Authors: Arnberger Arne , Schneider Ingrid E , Eder Renate , Choi Ami 
Published: December 2019

AbstractEmerald ash borer (EAB), an invasive forest insect from Asia, has impacted vast areas in the United States and European Russia. To proactively understand the social impact of an EAB invasion in Europe and the USA, this study analyzed visitors’ preferences and preference heterogeneity for EAB-impacted forest scenarios in Vienna, Austria (n = 510) and Minneapolis, USA (n = 307). An image-based discrete choice experiment with latent-class analysis among on-site completed questionnaires in Vienna indicated four different visitor segments based on trade-offs among biophysical, social and viewscape elements. Within the forested environment, two segments placed greater importance on (bio)physical attributes and two on social aspects. Although all segments preferred a non-impacted ash forest, only one of the four identified the attribute describing EAB impacts and forest management as the most important attribute. Rather, visitor numbers and background viewscapes were more important than EAB impact and management to differentiate landscape preferences for three of the four segments. Differences in preferences were found between the Vienna and Minneapolis samples. Vienna respondents showed a higher preference for more natural conditions, disliked more the initial stage of EAB impact and placed more importance on background viewscapes and visitor numbers. Forest managers and greenspace planners need to consider the entirety of the forested condition, social and visual, for effective management and address that visitors differ in their preferences for all of these conditions.
Investigating the Generation and Spread of Numerical Misinformation: A Combined Eye Movement Monitoring and Social Transmission Approach
Authors: Coronel Jason C , Poulsen Shannon , Sweitzer Matthew D 
Published: December 2019

Abstract
Numerical facts play a prominent role in public discourse, but individuals often provide incorrect estimates of policy-relevant numerical quantities (e.g., the number of immigrants in the country). Across two studies, we examined the role of schemas in the creation of numerical misinformation, and how misinformation can spread via person-to-person communication. In our first study, we combined eye movement monitoring and behavioral methods to examine how schemas distorted what people remembered about policy-relevant numerical information. Then, in a second study, we examined the consequences of these memory distortions via the social transmission of numerical information, using the serial reproduction paradigm. We found that individuals misremembered numerical information in a manner consistent with their schemas, and that person-to-person transmission can exacerbate these memory errors. Our studies highlight the mechanisms supporting the generation and spread of numerical misinformation and demonstrate the utility of a multi-method approach in the study of misinformation.
Progressive cardiac arrhythmias and ECG abnormalities in the Huntington’s disease BACHD mouse model
Authors: Zhu Yujie , Shamblin Isaac , Rodriguez Efrain , Salzer Grace E , Araysi Lita , Margolies Katherine A , Halade Ganesh V , Litovsky Silvio H , Pogwizd Steven , Gray Michelle , Huke Sabine 
Published: December 2019

Abstract
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease. There is accumulating evidence that HD patients have increased prevalence of conduction abnormalities and compromised sinoatrial node function which could lead to increased risk for arrhythmia. We used mutant Huntingtin (mHTT) expressing bacterial artificial chromosome Huntington’s disease mice to determine if they exhibit electrocardiogram (ECG) abnormalities involving cardiac conduction that are known to increase risk of sudden arrhythmic death in humans. We obtained surface ECGs and analyzed arrhythmia susceptibility; we observed prolonged QRS duration, increases in PVCs as well as PACs. Abnormal histological and structural changes that could lead to cardiac conduction system dysfunction were seen. Finally, we observed decreases in desmosomal proteins, plakophilin-2 and desmoglein-2, which have been reported to cause cardiac arrhythmias and reduced conduction. Our study indicates that mHTT could cause progressive cardiac conduction system pathology that could increase the susceptibility to arrhythmias and sudden cardiac death in HD patients.
Returning Insurgency to the Archive: the Dissemination of the ‘Philosophy of the Bomb’
Authors: Maclean Kama 
Published: December 2019

Abstract
The recent surge of scholarly writing on seditious material in British India tends to focus on the reception and analysis of the content of proscribed publications. We still have scant knowledge of how revolutionary literature was produced and disseminated, partly because of the necessary secrecy in which this took place. Intelligence reports and revolutionary memoirs alike tend to describe the distribution of revolutionary literature in vague terms, almost invariably using the passive voice – ‘offensive pamphlets appeared’ or were simply ‘found’ in such and such a place – as though they somehow distributed themselves. In this paper, I turn my focus to the ways in which revolutionaries of the Hindustan Socialist Republican Association (HSRA) distributed ‘The Philosophy of the Bomb’ in January 1930. Following the HSRA’s daring attempt on the life of the Viceroy in December 1929, the Government of India’s search for key members and their sympathizers took on a renewed urgency. In an attempt to trace the revolutionaries and to break ‘the steel frame of the violence movement’, the Intelligence Bureau turned its attention to the distribution of this polemical document (a four-page riposte to Gandhi’s critique of revolutionary praxis. Analysis of modes of distribution of material on the verge of proscription, I argue, enables a more textured understanding of the thrust of revolutionary literature and its reception. This paper therefore aims to inject the spirit of insurgency into the archive by explaining the ways in which a key document of the Hindustan Socialist Republican Association (HSRA), ‘The Philosophy of the Bomb’, was disseminated in early 1930. The paper is organized into three sections. The first section provides a background for the political context of ‘The Philosophy of the Bomb’ amid debates about violence and nonviolence in the broader nationalist movement. The second describes the different ways in which the document was disseminated in early 1930, drawing on both revolutionary and intelligence reports. The paper then concludes by considering the alignment between the dissemination and impact of the revolutionary manifesto and the bomb itself.
Preoperative skeletal muscle density is associated with postoperative mortality in patients with cardiovascular disease
Authors: Yamashita Masashi , Kamiya Kentaro , Matsunaga Atsuhiko , Kitamura Tadashi , Hamazaki Nobuaki , Matsuzawa Ryota , Nozaki Kohei , Ichikawa Takafumi , Nakamura Takeshi , Yamamoto Shohei , Kariya Hidenori , Maekawa Emi , Meguro Kentaro , Ogura Misao , Yamaoka-Tojo Minako , Ako Junya , Miyaji Kagami 
Published: December 2019

Abstract

OBJECTIVES
Although skeletal muscle density (SMD) is useful for predicting mortality, the cut-off in an acute clinical setting is unclear, especially in patients with cardiovascular disease (CVD). This study was performed to determine the preoperative SMD cut-off using the psoas muscle and to investigate the effect on postoperative outcomes, including sarcopaenia, in CVD patients.

METHODS
Preoperative psoas SMD was measured by abdominal computed tomography in CVD patients. Postoperative sarcopaenia was defined according to the criteria of the Asia Working Group for Sarcopaenia. The Youden index was used to test the predictive accuracy of survival models. The prognostic capability was evaluated using multivariable survival and receiver operating characteristic curve analyses.

RESULTS
Continuous data were available for 1068 patients (mean age 65.5 years; 63.6% male). A total of 105 (9.8%) deaths occurred during the 1.99-year median follow-up period (interquartile range 0.71–4.15). The psoas SMD cut-off estimated by the Youden index was 45 Hounsfield units with high sensitivity and moderate specificity for all-cause mortality and was consistent in various stratified analyses. After adjusting for the existing prognostic model, EuroSCORE II, preoperative and postoperative physical status, psoas SMD cut-off was predicted for mortality (hazard ratio 2.42, 95% confidence interval 1.32–4.45). The psoas SMD cut-off was also significantly associated with postoperative sarcopaenia and provided additional prognostic information to EuroSCORE II on receiver operating characteristic curve analysis (area under the curve 0.627 vs 0.678, P = 0.011).

CONCLUSIONS
Reduced psoas SMD was associated with postoperative mortality and added information prognostic for mortality to the existing prognostic model in CVD patients.
The Weil Algebra of a Double Lie Algebroid
Authors: Meinrenken Eckhard , Pike Jeffrey 
Published: December 2019

Abstract
Given a double vector bundle $D\to M$, we define a bigraded bundle of algebras $W(D)\to M$ called the “Weil algebra bundle”. The space ${\mathcal{W}}(D)$ of sections of this algebra bundle ”realizes” the algebra of functions on the supermanifold $D[1,1]$. We describe in detail the relations between the Weil algebra bundles of $D$ and those of the double vector bundles $D^{\prime},\ D^{\prime\prime}$ obtained from $D$ by duality operations. We show that ${\mathcal{V}\mathcal{B}}$-algebroid structures on $D$ are equivalent to horizontal or vertical differentials on two of the Weil algebras and a Gerstenhaber bracket on the 3rd. Furthermore, Mackenzie’s definition of a double Lie algebroid is equivalent to compatibilities between two such structures on any one of the three Weil algebras. In particular, we obtain a ”classical” version of Voronov’s result characterizing double Lie algebroid structures. In the case that $D=TA$ is the tangent prolongation of a Lie algebroid, we find that ${\mathcal{W}}(D)$ is the Weil algebra of the Lie algebroid, as defined by Mehta and Abad–Crainic. We show that the deformation complex of Lie algebroids, the theory of IM forms and IM multi-vector fields, and 2-term representations up to homotopy all have natural interpretations in terms of our Weil algebras.
Time-Dependent Effects of Relational Composition on the Success of Online Wellness Challenge Groups
Authors: Meng Jingbo , Shin Soo Yun , Bae Arram , Van Der Heide Brandon 
Published: December 2019

Abstract
This study aims to examine time-dependent effects of group-level relational composition, including the number and cohesion of prior online relationships and multiple-group membership (MGM), on the success of online wellness challenge groups (OWCGs) in promoting positive health behavior among group members. Bridging literature on online groups and social networks for health, this study collected data on 1,252 OWCGs and conducted analyses on how relational composition affected group success longitudinally over the life span of the OWCGs. The results showed that the number of prior online relationships within a group had a positive but decreasing effect over time on group success, whereas cohesion was not a significant predictor. MGM, indicating members' concurrent participation in multiple OWCGs, showed a positive effect on group success at the beginning but a negative effect towards the end of a group's life span. Theoretical and practical implications for designing successful OWCGs were discussed.
Easy Statistical Mediation Analysis With Distinguishable Dyadic Data
Authors: Coutts Jacob J , Hayes Andrew F , Jiang Tao 
Published: December 2019

AbstractResearch in communication and other social science disciplines that relies on measuring each member of a dyad on putative causes and effects can require complex analyses to illuminate how members of the dyad influence one another. Dyadic mediation analysis is a branch of mediation analysis that focuses on establishing the mechanism(s) by which mutual influence operates. Relying on the similarity between dyadic mediation analysis using structural equation modeling and mediation analysis with ordinary least squares regression, we developed MEDYAD, an easy-to-use computational tool for SPSS, SAS, and R that conducts dyadic mediation analysis with distinguishable dyadic data. MEDYAD implements the Actor-Partner Interdependence Model Extended to Mediation (APIMeM), as well as simpler and more complex dyadic mediation models. Bootstrapping methods are implemented for inferences about indirect effects. Additional features include methods for conducting all possible pairwise comparisons between indirect effects, heteroskedasticity-robust inference, and saving bootstrap estimates of parameters for further analysis.
Systematic Review and Meta-Analysis of Anxiety and Depression in Youth With Epilepsy
Authors: Scott Amelia J , Sharpe Louise , Loomes Max , Gandy Milena 
Published: December 2019

Abstract

Objective
The aim of this systematic review and meta-analysis was to provide an estimate of the prevalence of anxiety and depressive disorders in youth with epilepsy (YWE). It also aimed to calculate the overall magnitude of observed differences in anxiety and depressive symptoms reported by YWE compared with healthy controls and investigate whether any factors moderated anxiety and depression outcomes in YWE.

Methods
Following prospective registration, electronic databases were searched up until October 2018. Studies were included if they reported on the rate of anxiety or depression in samples of YWE, and/or if they used valid measures of anxious or depressive symptomatology in YWE compared with a healthy control sample.

Results
Twenty-three studies met inclusion criteria. The overall pooled prevalence of anxiety disorders in YWE was 18.9% (95% confidence interval [CI] 12.0%–28.5%), and for depression the pooled prevalence was 13.5% (95% CI 8.8%–20.2%). In samples of YWE compared with healthy controls, significantly higher anxiety (d = 0.57, 95% CI 0.32–0.83, p &lt; .000) and depressive (d = 0.42, 95% CI 0.16–0.68, p &lt; .000) symptomatology was reported.

Conclusions
YWE report anxiety and depressive disorders and symptoms to a significantly higher degree than youth without epilepsy. There is also evidence that certain anxiety disorders (e.g. generalized anxiety disorder, separation anxiety disorder) are particularly elevated, perhaps reflecting the unique impact of epilepsy on youth psychopathology. Research is needed to understand the risk factors associated with anxiety and depressive disorders in epilepsy, and better understand how these symptoms change across development.
Hospital-level Antibiotic Use and Complexity of Care Among Neonates
Authors: Singh Prachi , Steurer Martina A , Cantey Joseph B , Wattier Rachel L 
Published: December 2019

AbstractBackgroundDespite increasing neonatal antibiotic stewardship efforts, understanding of interhospital variation in neonatal antibiotic use is limited.MethodsA retrospective cohort study was conducted among primarily academically affiliated hospitals participating in the Vizient Clinical Database/Resource Manager. Neonatal discharges were identified by admission age &lt;1 month, excluding nonviable neonates and normal newborns. Hospitals with ≥100 neonatal discharges and complete data for January-December 2016 were included. Antibiotic use was measured in days of therapy per 1000 patient-days (DOT/1000 pd). A composite measure of neonatal care complexity (NCC; low, medium, high) was based on the volume of very low-birth-weight neonates and neonates undergoing surgical procedures, cardiac surgery, or extracorporeal membranous oxygenation.ResultsThe 118 included hospitals represented 184 716 neonatal discharges; 22 hospitals with low NCC, 56 with medium NCC, and 40 with high NCC. Mean antibiotic DOT/1000 pd was 363 (standard deviation [SD], 94) in high NCC hospitals, 243 (SD, 88) in medium NCC hospitals, and 184 (SD, 122) in low NCC hospitals. Increasing NCC was associated with higher antibiotic use, with an incidence rate ratio (IRR) of 1.95 (95% confidence interval [CI], 1.55 to 2.47) for high vs low NCC and IRR 1.31 (95% CI, 1.05 to 1.64) for medium vs low NCC. Increasing case mix index was associated with higher antibiotic use (IRR 1.86 per unit increase; 95% CI, 1.50 to 2.31).ConclusionsAggregate antibiotic use among hospitalized neonates varies based on care complexity. Substantial variation despite stratification by complexity suggests incomplete risk adjustment and/or avoidable variation in care.
Arabidopsis sucrose synthase localization indicates a primary role in sucrose translocation in phloem
Authors: Yao Danyu , Gonzales-Vigil Eliana , Mansfield Shawn D 
Published: December 2019

Abstract
Sucrose synthase (SuSy) is one of two enzyme families capable of catalyzing the first degradative step in sucrose utilization. Several earlier studies examining SuSy mutants in Arabidopsis failed to identify obvious phenotypic abnormalities compared with wild-type plants in normal growth environments, and as such a functional role for SuSy in the previously proposed cellulose biosynthetic process remains unclear. Our study systematically evaluated the precise subcellular localization of all six isoforms of Arabidopsis SuSy via live-cell imaging. We showed that yellow fluorescent protein (YFP)-labeled SuSy1 and SuSy4 were expressed exclusively in phloem companion cells, and the sus1/sus4 double mutant accumulated sucrose under hypoxic conditions. SuSy5 and SuSy6 were found to be parietally localized in sieve elements and restricted only to the cytoplasm. SuSy2 was present in the endosperm and embryo of developing seeds, and SuSy3 was localized to the embryo and leaf stomata. No single isoform of SuSy was detected in developing xylem tissue of elongating stem, the primary site of cellulose deposition in plants. SuSy1 and SuSy4 were also undetectable in the protoxylem tracheary elements, which were induced by the vascular-related transcription factor VND7 during secondary cell wall formation. These findings implicate SuSy in the biological events related to sucrose translocation in phloem.