bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroweak corrections to the fermionic decays of heavy Higgs states
Authors: Domingo Florian , Paßehr Sebastian 
Published: November 2019

Abstract
Extensions of the standard model often come with additional, possibly electroweakly charged Higgs states, the prototypal example being the Two-Higgs-Doublet Model. While collider phenomenology does not exclude the possibility for some of these new scalar fields to be light, it is relatively natural to consider masses in the multi-TeV range, in which case the only remaining light Higgs boson automatically receives SM-like properties. The appearance of a hierarchy between the new-physics states and the electroweak scale then leads to sizable electroweak corrections, e. g. in the decays of the heavy Higgs bosons, which are dominated by effects of infrared type, namely Sudakov logarithms. Such radiative contributions obviously affect the two-body decays, but should also be paired with the radiation of electroweak gauge bosons (or lighter Higgs bosons) for a consistent picture at the one-loop order. Resummation of the leading terms is also relatively easy to achieve. We re-visit these questions in the specific case of the fermionic decays of heavy Higgs particles in the Next-to-Minimal Supersymmetric Standard Model, in particular pointing out the consequences of the three-body final states for the branching ratios of the heavy scalars.
On the resolution of regional archaeomagnetism: untangling directional geomagnetic oscillations and data uncertainties using the French archaeomagnetic database for dates between AD 1000 and 1500 as a guide
Authors: Le Goff Maxime , Gallet Yves 
Published: November 2019

Abstract
A complexity is emphasized in the distribution of French archaeomagnetic directions during the thirteenth and the fourteenth centuries AD. Data uncertainties, and the smoothing introduced when estimating an average secular variation curve, prevent scrutiny of the very nature of this complexity. It might correspond to a directional yaw, the nature of which would be compatible with the recent geomagnetic field evolution as traced by the gufm1 model. In order to emphasize this indeterminacy, a reference secular variation curve was constructed for dates between AD 1000 and 1500, including the yaw in question, and synthetic databases that mimic the accuracy and density characteristics of the true French archaeomagnetic database were considered for some of these. The synthetic curves hence obtained show that the dating accuracy of archaeomagnetic data is the crucial parameter for constructing a detailed secular variation path. The significant impact of the experimental data accuracy is also illustrated. Even more crucial is the fact that the precision of the data dating required to describe the directional variability over the century timescale largely exceeds the precision of the archaeological dates available for the structures generally studied. This highlights the intrinsic limitation of archaeomagnetism for regional reconstruction of century-scale geomagnetic field variations.
Penetrance Estimates Over Time to First and Second Primary Cancer Diagnosis in Families with Li-Fraumeni Syndrome: A Single Institution Perspective
Authors: Shin Seung Jun , Dodd-Eaton Elissa B. , Gao Fan , Bojadzieva Jasmina , Chen Jingxiao , Kong Xianhua , Amos Christopher I. , Ning Jing , Strong Louise C. , Wang Wenyi 
Published: November 2019

Abstract

Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder associated with TP53 germline mutations and an increased lifetime risk of multiple primary cancers (MPC). Penetrance estimation of time to first and second primary cancer within LFS remains challenging because of limited data and the difficulty of characterizing the effects of a primary cancer on the penetrance of a second primary cancer. Using a recurrent events survival modeling approach that incorporates a family-wise likelihood to efficiently integrate the pedigree structure, we estimated the penetrance for both first and second primary cancer diagnosis from a pediatric sarcoma cohort at MD Anderson Cancer Center [MDACC, Houston, TX; number of families = 189; single primary cancer (SPC) = 771; and MPC = 87]. Validation of the risk prediction performance was performed using an independent MDACC clinical cohort of TP53 tested individuals (SPC = 102 and MPC = 58). These findings showed that an individual diagnosed at a later age was more likely to be diagnosed with a second primary cancer. In addition, TP53 mutation carriers had a HR of 1.65 (95% confidence interval, 1.1–2.5) for developing a second primary cancer versus SPC. The area under the ROC (AUC) curve for predicting individual outcomes of MPC versus SPC was 0.77. In summary, we provide the first set of penetrance estimates for first and second primary cancer for TP53 germline mutation carriers and demonstrate its accuracy for cancer risk assessment.

Significance:
These findings present an open-source R package LFSPRO that could be used for genetic counseling and health management of individuals with LFS as it estimates the risk of both first and second primary cancer diagnosis.
See related article by Shin et al., p. 354
Disparities in Hepatocellular Carcinoma Incidence in California: An Update
Authors: Sangaramoorthy Meera , Yang Juan , DeRouen Mindy C. , Ho Chanda , Somsouk Ma , Tana Michele M. , Thompson Caroline A. , Gibbons Joseph , Gomez Scarlett Lin , Shariff-Marco Salma 
Published: November 2019

Abstract

Background:
Given changes in hepatocellular carcinoma (HCC) incidence and the ethnodemographic landscape, we analyzed recent HCC incidence patterns and trends in California.

Methods:
Using 47,992 primary, invasive HCC cases diagnosed from 1988 to 2014 from the California Cancer Registry, we calculated age-adjusted incidence rates (IR), annual percent change (APC), and 95% confidence intervals (CI) by sex, race/ethnicity, and nativity among Hispanics and Asian ethnic groups.

Results:
Compared with non-Hispanic Whites (NHW), all other racial/ethnic groups had higher HCC incidence. Vietnamese had the highest IRs (males: 47.4, 95% CI, 45.3–49.5; females: 14.1, 95% CI, 13.0–15.3). Foreign-born Chinese, Japanese, Korean, and Vietnamese had higher incidence than U.S.-born. The reverse was observed for Hispanic males, whereas no differences by nativity were seen for Hispanic females. IRs increased most for NHWs. Among Asians, male and female Filipinos and Japanese males experienced rate increases, whereas male and female Koreans and Chinese males experienced rate decreases. U.S.-born male and female Hispanics and Japanese had higher APCs than foreign-born, as did Filipino males, whereas Chinese males had a reverse pattern. Annual increases in HCC incidence slowed down in recent years for U.S.-born Hispanic males and females and stabilized among male NHWs and non-Hispanic Blacks. For some Asian groups, early time periods exhibited increasing/stable APCs, whereas later time periods showed decreasing APCs.

Conclusions:
We found significant racial/ethnic and nativity differences in HCC IRs and trends.

Impact:
With changing trends, closer surveillance of HCC incidence by disaggregated race/ethnicity and nativity is warranted among Hispanics and Asians.
Circulating Antibodies against Epstein–Barr Virus (EBV) and p53 in EBV-Positive and -Negative Gastric Cancer
Authors: Camargo M. Constanza , Kim Kyoung-Mee , Matsuo Keitaro , Torres Javier , Liao Linda M. , Morgan Douglas , Michel Angelika , Waterboer Tim , Song Minkyo , Gulley Margaret L. , Dominguez Ricardo L. , Yatabe Yasushi , Kim Sung , Cortes-Martinez Gustavo , Lissowska Jolanta , Zabaleta Jovanny , Pawlita Michael , Rabkin Charles S. 
Published: November 2019

Abstract

Background:
Epstein–Barr virus (EBV)-positive gastric cancers have clinicopathologic differences from EBV-negative tumors and lack TP53 mutation. Serologic profiles may inform viral contribution to carcinogenesis.

Methods:
We compared humoral responses of EBV-positive (n = 67) and EBV-negative (n = 137) patients with gastric cancer from the International EBV-Gastric Cancer Consortium. Serum antibodies against four EBV proteins, nuclear (EBNA), viral capsid (VCA), early-diffuse (EA-D), and Zta replication activator (ZEBRA), and to p53 were assessed by multiplex assays. OR of antibody level tertiles (T1–T3) were adjusted by logistic regression. We also conducted a meta-analysis of reported anti-p53 seropositivity in gastric cancer.

Results:
Consistent with EBV's ubiquity, 99% of patients were seropositive for anti-EBNA and 98% for anti-VCA, without difference by tumor EBV status. Seropositivity varied between patients with EBV-positive and EBV-negative tumors for anti-EA-D (97% vs. 67%, respectively, P &lt; 0.001) and anti-ZEBRA (97% vs. 85%, respectively, P = 0.009). Adjusted ORs (vs. T1) for patients with EBV-positive versus EBV-negative tumors were significantly elevated for higher antibodies against EBNA (2.6 for T2 and 13 for T3), VCA (1.8 for T2 and 2.4 for T3), EA-D (6.0 for T2 and 44 for T3), and ZEBRA (4.6 for T2 and 12 for T3). Antibodies to p53 were inversely associated with EBV positivity (3% vs. 15%; adjusted OR = 0.16, P = 0.021). Anti-p53 prevalence from the literature was 15%.

Conclusions:
These serologic patterns suggest viral reactivation in EBV-positive cancers and identify variation of p53 seropositivity by subtype.

Impact:
Anti-EBV and anti-p53 antibodies are differentially associated with tumor EBV positivity. Serology may identify EBV-positive gastric cancer for targeted therapies.
Carlo Denina’s Lettres Critiques: Transnational History in an Age of Information Overload
Authors: Corredera Edward Jones 
Published: November 2019

Abstract
This article recovers the transnational historical approach of the eighteenth-century Piedmontese thinker Carlo Denina (1731-1813) and his Lettres Critiques. The Lettres, which have remained largely overlooked to this day, addressed a number of cultural debates on the epistemology of the Encyclopédie, the art of translation, and European geopolitics, by drawing on a transnational approach to the history of Europe. This article frames Denina’s transnational gaze in the context of early modern concerns over information overload and eighteenth-century ideas of cultural superiority and alterity. The article follows the ways the Lettres Critiques addressed three querelles: Morvilliers’ 1782 rhetorical attack on Spain, German debates on the merits of French culture and the nature of knowledge, and Madrid’s protracted response to William Robertson’s History of America (1777). The article sheds light on an overlooked eighteenth-century vision of transnational history as a solution to embryonic forms of nationalism and the politicization of knowledge.
Response of flower visitors to the morphology and color of crab spiders in a coastal environment of the Gulf of Mexico
Authors: Rodríguez-Morales Dulce , Ajuria-Ibarra Helena , Hernández-Salazar Laura T. , Rico-Gray Víctor , García-Franco José G. , Rao Dinesh 
Published: November 2019

Abstract
Predation is one of the main interactions between organisms and one of the primary selective agents for their survival. Both prey and predators have developed different strategies and characteristics that allow them to be conspicuous or go undetected. In sit and wait predators, their shape and appearance are important factors that allow them to remain undetected by their potential prey. Sit and wait predators such as crab spiders are difficult to identify when they sit on flowers or areas of flowers with colors similar to the color of their bodies. In this study, we aimed to determine if insects can recognize the morphology and color polymorphism of crab spiders by evaluating the response of flower visitors. We quantified the visits and approaches of floral visitors to the flowerheads of Palafoxia lindenii with spider morphology and color polymorphism treatments. Our results show that insects in general, and bees in particular, avoid visiting flowers with a real spider or a spider model and visit vacant flowers more frequently. In the case of the color polymorphism, insects approached flowerheads with spiders with a similar frequency independently of the color of the spiders, but did not visit them. Insects appeared to identify spiders through their morphological characteristics rather than their color characteristics, since flower visitors did not discriminate between the evaluated spider colors (white, lilac, and purple). This study emphasizes the differential response of different insect prey to the presence, color, and morphology of sit and wait predators.
Foraging modes of carnivorous plants
Authors: Ellison Aaron M. 
Published: November 2019

Abstract
Carnivorous plants are pure sit-and-wait predators: they remain rooted to a single location and depend on the abundance and movement of their prey to obtain nutrients required for growth and reproduction. Yet carnivorous plants exhibit phenotypically plastic responses to prey availability that parallel those of non-carnivorous plants to changes in light levels or soil-nutrient concentrations. The latter have been considered to be foraging behaviors, but the former have not. Here, I review aspects of foraging theory that can be profitably applied to carnivorous plants considered as sit-and-wait predators. A discussion of different strategies by which carnivorous plants attract, capture, kill, and digest prey, and subsequently acquire nutrients from them suggests that optimal foraging theory can be applied to carnivorous plants as easily as it has been applied to animals. Carnivorous plants can vary their production, placement, and types of traps; switch between capturing nutrients from leaf-derived traps and roots; temporarily activate traps in response to external cues; or cease trap production altogether. Future research on foraging strategies by carnivorous plants will yield new insights into the physiology and ecology of what Darwin called “the most wonderful plants in the world”. At the same time, inclusion of carnivorous plants into models of animal foraging behavior could lead to the development of a more general and taxonomically inclusive foraging theory.
Community Assessment of Colorectal Cancer Screening Compliance in Northwest Louisiana
Authors: Holden Stephanie 
Published: November 2019

Background In the United States, colorectal cancer (CRC) screening rates have steadily increased. The state of Louisiana has persistent lower screening rates compared to the United States and other states, and with African Americans experiencing the highest CRC incidence rates. Aggregate national and state data can be problematic in isolating key health issues and data in rural areas. Study Purpose: At the Louisiana parish-level, which is comparable to county municipalities in other U.S. states, the research study examined endoscopy CRC screening among African American Medicare beneficiaries. Method Using cluster sampling, survey-based data from two neighboring parishes in northwest Louisiana were collected. The survey instrument was adapted from the Medicare Current Beneficiary Survey. Results The key study variables were CRC screening compliance, residence location, self-reported CRC knowledge, and physician recommendation. The findings showed significant differences in CRC screening compliance between the two parishes. Participants with CRC knowledge score of at least 3 out of 5 were more likely to be compliant with CRC screening. The findings demonstrated the importance of isolating geo-specific data, especially in rural areas, to plan effective health education or intervention strategies.
Near-Infrared Optical Nanosensors for Continuous Detection of Glucose
Authors: Le Long V. , Chendke Gauree S. , Gamsey Soya , Wisniewski Natalie , Desai Tejal A. 
Published: November 2019

Background: Continuous glucose monitors (CGMs) enable people with diabetes to proactively manage their blood glucose and reduce the risk of hypoglycemia. Commercially available CGMs utilize percutaneous electrodes that, after days to weeks of implantation, are subjected to the foreign body response that severely reduces sensor accuracy. The previous work demonstrated the use of hydrogels containing a glucose-responsive viologen that quenches a nearby fluorophore. Here, we investigate the immobilization of this sensing motif onto a nanoparticle surface and optimize local surface concentrations for optical glucose sensing. Methods: A viologen quencher-fluorescent dye system was incorporated into poly(2-hydroethyl methacrylate) hydrogels in varying quantities to assess the effect of quencher-fluorophore concentration on glucose responsiveness. The sensing motif was then immobilized onto silica nanoparticles by carbodiimide chemistry. Nanosensors with a range of dye and quencher concentrations were challenged for glucose responsiveness to determine the optimal sensor formulation. Results: When incorporated into a hydrogel, high concentrations of viologen quencher and fluorophore were required to permit electron transfer between the two components and yield a detectable glucose response. Immobilization of this glucose-responsive system onto a silica nanoparticle facilitated this electron transfer to yield detectable responses at even low concentrations. Increasing quencher concentration on the nanoparticle, relative to the fluorophore, resulted in the greatest apparent glucose response. Conclusion: The nanoparticle sensors demonstrated excellent glucose response in the physiological range and are a promising tool for real-time glucose tracking.
The Cost-Effectiveness of Vancomycin Powder in Lumbar Laminectomy
Authors: Kerbel Yehuda E. , Kirchner Gregory J. , Sunkerneni Anisha Reddy , Lieber Alexander M. , Moretti Vincent M. , Khalsa Amrit S. , Levine Marc J. 
Published: November 2019

Study Design: Break-even cost analysis. Objective: The goal of this study is to examine the cost-effectiveness of vancomycin powder for preventing infection following lumbar laminectomy. Methods: The product cost of vancomycin powder was obtained from our institution’s purchasing records. Infection rates and revision costs for lumbar laminectomy and lumbar laminectomy with fusion were obtained from the literature. A break-even analysis was then performed to determine the absolute risk reduction (ARR) in infection rate to make prophylactic application of vancomycin powder cost-effective. Analysis of lumbar laminectomy with fusion was performed for comparison. Results: Costing $3.06 per gram at our institution, vancomycin powder was determined to be cost-effective in lumbar laminectomy if the infection rate of 4.2% decreased by an ARR of 0.015%. Laminectomy with fusion was also determined to be cost-effective at the same cost of vancomycin powder if the infection rate of 8.5% decreased by an ARR of 0.0034%. The current highest cost reported in the literature, $44.00 per gram of vancomycin powder, remained cost-effective with ARRs of 0.21% and 0.048% for laminectomy and laminectomy with fusion, respectively. Varying the baseline infection rate did not influence the ARR for either procedure when the analysis was performed using the product cost of vancomycin at our institution. Conclusions: This break-even analysis demonstrates that prophylactic vancomycin powder can be highly cost-effective for lumbar laminectomy. At our institution, vancomycin powder is economically justified if it prevents at least one infection out of 6700 lumbar laminectomy surgeries.
OsProT1 and OsProT3 Function to Mediate Proline- and γ-aminobutyric acid-specific Transport in Yeast and are Differentially Expressed in Rice (Oryza sativa L.)
Authors: Lin Jin-Hong , Xu Zhi-Jun , Peng Jia-Shi , Zhao Jing , Zhang Guo-Bin , Xie Jun , Yi Zhen-Xie , Zhang Jian-Hua , Gong Ji-Ming , Ye Neng-Hui , Meng Shuan 
Published: November 2019

Abstract

Background
Proline (Pro) and γ-aminobutyric acid (GABA) play important roles in plant development and stress tolerance. However, the molecular components responsible for the transport of these molecules in rice remain largely unknown.

Results
Here we identified OsProT1 and OsProT3 as functional transporters for Pro and GABA. Transient expression of eGFP-OsProTs in plant protoplasts revealed that both OsProT1 and OsProT3 are localized to the plasma membrane. Ectopic expression in a yeast mutant demonstrated that both OsProT1 and OsProT3 specifically mediate transport of Pro and GABA with affinity for Pro in the low affinity range. qRT-PCR analyses suggested that OsProT1 was preferentially expressed in leaf sheathes during vegetative growth, while OsProT3 exhibited relatively high expression levels in several tissues, including nodes, panicles and roots. Interestingly, both OsProT1 and OsProT3 were induced by cadmium stress in rice shoots.

Conclusions
Our results suggested that plasma membrane-localized OsProT1 and OsProT3 efficiently transport Pro and GABA when ectopically expressed in yeast and appear to be involved in various physiological processes, including adaption to cadmium stress in rice plants.
Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes
Authors: Ogungbemi Afolarin , Leuthold David , Scholz Stefan , Küster Eberhard 
Published: November 2019

AbstractTests with zebrafish embryos have gained wide acceptance as an alternative test model for drug development and toxicity testing. In particular, the behavioral response of the zebrafish embryo is currently seen as a useful endpoint to diagnose neuroactive substances. Consequently, several behavioral test methods have been developed addressing various behavioral endpoints such as spontaneous tail coiling (STC), photomotor response (PMR), locomotor response (LMR) and alternating light/dark-induced locomotor response (LMR-L/D). Although these methods are distinct in their application, most of their protocols differ quite strongly in the use of experimental parameters and this is usually driven by different research questions. However, if a single mode of action is to be diagnosed, then varying experimental parameters may cause incoherent behavioral responses (hypo- or hyperactivity) of zebrafish during toxicity assessment. This could lead to inconclusiveness of behavioral test results for use within a prospective and diagnostic risk assessment framework. To investigate the influence of these parameters, we conducted a review of existing behavioral assays to address the following two questions: (1) To what extent do varying experimental parameters influence observed effects in published behavioral test methods? (2) Is the observed behavior change (hypo- or hyperactivity) of zebrafish embryos consistent with the expected mode of action of a chemical? We compiled a set of 18 substances which are anticipated to be neuroactive. We found that behavioral changes are not only affected by chemicals but also variation in the use of experimental parameters across studies seems to have a high impact on the outcome and thus comparability between studies. Four parameters, i.e., exposure concentration, exposure duration, endpoint parameter and developmental stage were the most influential parameters. Varying combinations of these parameters caused a non-reproducible outcome for the hyperactivity expected for the organophosphates; chlorpyrifos and diazinon. We highlighted that the STC test shows a higher capacity to predict the hyperactivity of organophosphates, while PMR and LMR-L/D were more suitable to predict the hypoactivity expected for anticonvulsants. We provide a list of recommendations which, when implemented, may help to exclude the risk of bias due to experimental parameters if similar goals are desired.