bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interprofessional Collaboration in Dentistry: Role of physiotherapists to improve care and outcomes for chronic pain conditions and sleep disorders
Authors: Herrero Babiloni Alberto , Lam Jacqueline T. A. T. , Exposto Fernando G. , Beetz Gabrielle , Provost Catherine , Gagnon Dany H. , Lavigne Gilles J. 
Published: June 2020

AbstractPhysiotherapists can manage chronic pain patients by using technical interventions such as mobility, strengthening, manual therapy, or flexibility in a specific and functional manner, being a key component of a multidisciplinary team. Dentists are involved in the management of different chronic pain conditions such as temporomandibular disorders and sleep disorders such as obstructive sleep apnea. However, they are frequently unaware of the benefits of collaborating with physical therapists. In this review, the collaboration of physical therapists and dentists will be explored when managing orofacial pain, headaches, and sleep disorders. The physical therapist is important in the management of these disorders and also in the screening of risk factors.
Upregulation of long non‐coding RNA FOXD2‐AS1 promotes progression and predicts poor prognosis in tongue squamous cell carcinoma
Authors: Zhou Guangming , Huang Zixian , Meng Yiyi , Jin Tingting , Liang Yancan , Zhang Bin 
Published: June 2020

AbstractBackgroundAccumulating evidences suggest that lncRNA FOXD2‐AS1 plays an important role in tumor progression, however, its function in tongue squamous cell carcinoma (TSCC) remains unknown. This research aims to investigate the function and mechanism of FOXD2‐AS1 in the modulation of tongue squamous cell carcinoma progression.MethodsExpression of FOXD2‐AS1 was detected in TSCC tissues and TCGA data. Receiver operating characteristic curves (ROCs) analysis and bioinformatic analysis of TCGA data were performed to investigate the role of FOXD2‐AS1 in TSCC prognosis. After siRNA‐mediated downregulation of FOXD2‐AS1, wound healing assay, Transwell migration and invasion assays, and MTS proliferation assay were conducted to explore the effects that FOXD2‐AS1 exerted on SCC‐9 and CAL‐27 cell lines. Western blotting was performed to detect the downstream protein changes.ResultsCompared to the normal tissues and samples, FOXD2‐AS1 significantly highly expressed in TSCC tissues and in TSCC samples of TCGA data, and high expression of FOXD2‐AS1 was associated with lymphatic metastasis and poor TNM stages. ROC analysis and bioinformatic analysis of TCGA data further suggested that high expression of FOXD2‐AS1 was associated with TSCC poor prognosis. Downregulation of FOXD2‐AS1 inhibited the migration and invasion of SCC‐9 and CAL‐27 cell lines. Western blotting showed that the expression of p‐p44 and p‐p65 downregulated after FOXD2‐AS1 knockdown.ConclusionHigh expression of FOXD2‐AS1 promotes TSCC progression through modulating NF‐kB and ERK MAPK signaling pathways and is associated with TSCC poor prognosis, it could be a novel therapeutic target and prognostic biomarker for TSCC.
The WetNet: What the Oral Polio Vaccine Hypothesis Exposes about Globalized Interspecies Fluid Bonds
Authors: Jain S. Lochlann 
Published: June 2020

AbstractThe author analyzes the aftermath of Edward Hooper's suggestion that the trial of an oral polio vaccine (OPV) in the Belgian colonies of Africa engendered the pandemic form of the AIDS virus, HIV‐1. In response to Hooper's book, The River (1999), the Royal Society in London held a conference to debate the origins of HIV. Examination of the quick dismissal of the OPV theory opens a space for legitimately challenging the widely held belief that the vaccine contamination question was convincingly resolved. This article interrogates the relationship between historiography and the making of scientific facts and history, suggesting that historians have been too credulous of scientists’ testimony. The further result of the lack of a thorough analysis of the evidence backing the OPV hypothesis has resulted in a missed opportunity to read The River as one of the few detailed accounts of the immense social, political, technological, and interspecies infrastructure constituted by Cold War vaccine production. This biomedical infrastructure dramatically changed the geographic and interspecies mobility of viruses in ways that may be impossible to reconstruct. Yet these potential transmission routes remain crucial to acknowledge. The COVID‐19 pandemic draws attention to the critical importance of studying The WetNet, a concept coined by the author to name the conceptual and material infrastructures of inter‐ and intraspecies fluid bonding.
Optimized metabarcoding with Pacific biosciences enables semi‐quantitative analysis of fungal communities
Authors: Castaño Carles , Berlin Anna , Brandström Durling Mikael , Ihrmark Katharina , Lindahl Björn D. , Stenlid Jan , Clemmensen Karina E. , Olson Åke 
Published: June 2020

Summary

Recent studies have questioned the use of high‐throughput sequencing of the nuclear ribosomal internal transcribed spacer (ITS) region to derive a semi‐quantitative representation of fungal community composition. However, comprehensive studies that quantify biases occurring during PCR and sequencing of ITS amplicons are still lacking.

We used artificially assembled communities consisting of 10 ITS‐like fragments of varying lengths and guanine‐cytosine (GC) contents to evaluate and quantify biases during PCR and sequencing with Illumina MiSeq, PacBio RS II and PacBio Sequel I technologies.

Fragment length variation was the main source of bias in observed community composition relative to the template, with longer fragments generally being under‐represented for all sequencing platforms. This bias was three times higher for Illumina MiSeq than for PacBio RS II and Sequel I. All 10 fragments in the artificial community were recovered when sequenced with PacBio technologies, whereas the three longest fragments (> 447 bases) were lost when sequenced with Illumina MiSeq. Fragment length bias also increased linearly with increasing number of PCR cycles but could be mitigated by optimization of the PCR setup. No significant biases related to GC content were observed.

Despite lower sequencing output, PacBio sequencing was better able to reflect the community composition of the template than Illumina MiSeq sequencing.
No evidence of homeostatic regulation of leaf temperature in Eucalyptus parramattensis trees: integration of CO2 flux and oxygen isotope methodologies
Authors: Drake John E. , Harwood Richard , Vårhammar Angelica , Barbour Margaret M. , Reich Peter B. , Barton Craig V. M. , Tjoelker Mark G. 
Published: June 2020

Summary

Thermoregulation of leaf temperature (Tleaf) may foster metabolic homeostasis in plants, but the degree to which Tleaf is moderated, and under what environmental contexts, is a topic of debate. Isotopic studies inferred the temperature of photosynthetic carbon assimilation to be a constant value of c. 20°C; by contrast, leaf biophysical theory suggests a strong dependence of Tleaf on environmental drivers. Can this apparent disparity be reconciled?

We continuously measured Tleaf and whole‐crown net CO2 uptake for Eucalyptus parramattensis trees growing in field conditions in whole‐tree chambers under ambient and +3°C warming conditions, and calculated assimilation‐weighted leaf temperature (TL‐AW) across 265 d, varying in air temperature (Tair) from −1 to 45°C. We compared these data to TL‐AW derived from wood cellulose δ18O.

Tleaf exhibited substantial variation driven by Tair, light intensity, and vapor pressure deficit, and Tleaf was strongly linearly correlated with Tair with a slope of c. 1.0. TL‐AW values calculated from cellulose δ18O vs crown fluxes were remarkably consistent; both varied seasonally and in response to the warming treatment, tracking variation in Tair.

The leaves studied here were nearly poikilothermic, with no evidence of thermoregulation of Tleaf towards a homeostatic value. Importantly, this work supports the use of cellulose δ18O to infer TL‐AW, but does not support the concept of strong homeothermic regulation of Tleaf
Bromelain reduces the non‐alcoholic fatty liver disease and periodontal damages caused by ligature‐induced periodontitis
Authors: Alves Even Herlany Pereira , Carvalho André dos Santos , Silva Felipe Rodolfo Pereira , Carvalho França Luiz Felipe , Di Lenardo David , Vasconcelos Any Carolina Cardoso Guimarães , Nascimento Hélio Mateus Silva , Ribeiro Lopes Víctor Lucas , Oliveira Jefferson Soares , Vasconcelos Daniel Fernando Pereira 
Published: June 2020

AbstractObjectiveThe objective of this research was to evaluate the effects of bromelain (derived from Ananas comosus) upon periodontitis in rats.Materials and MethodsTwenty‐four rats were separated into groups: control, periodontitis, and bromelain treatment. Bromelain was administered daily by intraperitoneal injection for 20 days. Periodontitis was induced by ligature around the first molars. Oral parameters and blood biomarkers were measured. The histopathological evaluation of the hepatic tissue was performed. Bromelain treatment significantly reduced several oral inflammatory parameters, alveolar bone loss, and blood biomarkers compared to the rats on periodontitis.ResultsTreatment with bromelain improved the steatosis score. Bromelain used in ligature‐induced periodontitis in rats was able to reduce the oral inflammatory parameters Gingival Bleeding Index (GBI), tooth mobility (TM), probing pocket depth (PPD), malondialdehyde (MDA), alveolar bone height (ABH) and gingival myeloperoxidase (MPO) and blood parameters (cholesterol, triglycerides, alanine aminotransferase, and aspartate aminotransferase). Bromelain treatment reduced the impact of periodontitis, such as the reduction of hepatic steatosis and improvement in the dosages of MDA and GSH.ConclusionBromelain acts as a potential adjunct in the non‐surgical treatment of periodontitis and, consequently, reduces the impact of periodontitis, acting as anti‐inflammatory and antioxidant.
The maize shoot ionome: Its interaction partners, predictive power, and genetic determinants
Authors: Stich Benjamin , Benke Andreas , Schmidt Maria , Urbany Claude , Shi Rongli , von Wirén Nicolaus 
Published: June 2020

AbstractAn improved understanding of how to manipulate the accumulation and enrichment of mineral elements in aboveground plant tissues holds promise for future resource efficient and sustainable crop production. The objectives of this study were to (a) evaluate the influence of Fe regimes on mineral element concentrations and contents in the maize shoot as well as their correlations, (b) examine the predictive ability of physiological and morphological traits of individual genotypes of the IBM population from the concentration of mineral elements, and (c) identify genetic factors influencing the mineral element composition within and across Fe regimes. We evaluated the concentration and content of 12 mineral elements in shoots of the IBM population grown in sufficient and deficient Fe regimes and found for almost all mineral elements a significant (α = 0.05) genotypic variance. Across all mineral elements, the variance of genotype*Fe regime interactions was on average even more pronounced. High prediction abilities indicated that mineral elements are powerful predictors of morphological and physiological traits. Furthermore, our results suggest that ZmHMA2/3 and ZmMOT1 are major players in the natural genetic variation of Cd and Mo concentrations and contents of maize shoots, respectively.
Polls and Elections: “The Carnivalesque in the 2016 US Presidential Campaign”
Authors: Mohammed Shaheed Nick , Trumpbour Robert C. 
Published: June 2020

AbstractThe 2016 U.S. general election saw the emergence of a nonpolitician celebrity, Donald Trump, who frequently challenged existing power structures and figures. Trump's electoral win combined with reports of violence at campaign rallies, calls for removal of those in power, the ridicule of opponents, and the use of invectives and name‐calling suggest parallels to Bakhtin's elucidation of the carnivalesque. The authors examined media coverage of the 2016 campaign to uncover evidence of carnivalesque references. Such references were significantly higher for Trump than for Democratic candidate Hillary Clinton and for the 2012 Republican campaign of Mitt Romney. The implications of presidential campaigns steeped in carnivalesque rhetoric and actions are discussed, with concerns raised regarding the future of media institutions and participatory democracy.
Molecular expression and identification of caprine estrogen receptor gene 1 for fertility status in bucks
Authors: Saraswat S , Kharche SD , Rout PK , Pawaiya R , Gangwar C , Swain DK , Kaushik R 
Published: June 2020

AbstractEstrogen and its receptors are essential for sexual development and reproduction. Oestrogen receptor alpha (ERα) is a nuclear receptor activated by the hormone oestrogen. In male, ERα is encoded by the gene ESR1 (oestrogen receptor1) responsible for better fertility. ESR1 is involved in the reabsorption of luminal fluid during the transit of spermatozoa from the testis to the head of the epididymis which is important for their survival and maturation during epididymal storage. The absence of ESR1 leads to reduced epididymal sperm content, reduced sperm motility and fertilizing ability. The present study was undertaken to investigate the expression and presence of ESR1 gene in fertile and low‐fertile male goat breeds. We identified ESR1 gene through various molecular tools. Genotyping was carried out by high resonance melting analysis using Roche Light Cycler 480(LC‐480) system and found three different genotypes. Genotypic frequency‐AA (blue‐0.67), BB(Red‐0.2), AB(Green‐0.08) with allele frequency A(0.71 and B (0.29). The predominance of this gene in head of epididymis in fertile bucks was confirmed by SDS‐PAGE, Western blotting and immunohistochemistry. From the results, we corroborated that the present study provides a useful and effective way to predict male fertility in goat breeds, which in turn increases the percentage of fertility in flock leading to more number of offspring in a kidding season.
Efficient or Fair? Operationalizing Ethical Principles in Flood Risk Management: A Case Study on the Dutch‐German Rhine
Authors: Ciullo Alessio , Kwakkel Jan H. , De Bruijn Karin M. , Doorn Neelke , Klijn Frans 
Published: June 2020

AbstractFlood risk management decisions in many countries are based on decision‐support frameworks which rely on cost‐benefit analyses. Such frameworks are seldom informative about the geographical distribution of risk, raising questions on the fairness of the proposed policies. In the present work, we propose a new decision criterion that accounts for the distribution of risk reduction and apply it to support flood risk management decisions on a transboundary stretch of the Rhine River. Three types of interventions are considered: embankment heightening, making Room for the River, and changing the discharge distribution of the river branches. The analysis involves solving a flood risk management problem according to four alternative formulations, based on different ethical principles. Formulations based on cost optimization lead to very poor performances in some areas for the sake of reducing the overall aggregated costs. Formulations that also include equity criteria have different results depending on how these are defined. When risk reduction is distributed equally, very poor economic performance is achieved. When risk is distributed equally, results are in line with formulations based on cost optimization, while a fairer risk distribution is achieved. Risk reduction measures also differ, with the cost optimization approach strongly favoring the leverage of changing the discharge distribution and the alternative formulations spending more on embankment heightening and Room for the River, to rebalance inequalities in risk levels. The proposed method advances risk‐based decision‐making by allowing to consider risk distribution aspects and their impacts on the choice of risk reduction measures.
A Resilience‐Based Approach to Risk Assessments—Building Resilient Organizations under Arctic Conditions
Authors: Taarup‐Esbensen Jacob 
Published: June 2020

AbstractReliability and higher levels of safety are thought to be achieved by using systematic approaches to managing risks. The assessment of risks has produced a range of different approaches to assessing these uncertainties, presenting models for how risks affect individuals or organizations. Contemporary risk assessment tools based on this approach have proven difficult for practitioners to use as tools for tactical and operational decision making. This article presents an alternative to these assessments by utilizing a resilience perspective, arguing that complex systems are inclined to variety and uncertainty regarding the results they produce and are therefore prone to systemic failures. A continuous improvement approach is a source of reliability when managing complex systems and is necessary to manage varieties and uncertainties. For an organization to understand how risk events occur, it is necessary to define what is believed to be the equilibrium of the system in time and space. By applying a resilience engineering (RE) perspective to risk assessment, it is possible to manage this complexity by assessing the ability to respond, monitor, learn, and anticipate risks, and in so doing to move away from the flawed frequency and consequences approach. Using a research station network in the Arctic as an example illustrates how an RE approach qualifies assessments by bridging risk assessments with value‐creation processes. The article concludes by arguing that a resilience‐based risk assessment can improve on current practice, including for organizations located outside the Arctic region.
Compassion with Justice: Harari’s Assault on Human Rights
Authors: Martin Mike W. 
Published: June 2020

AbstractYuval Noah Harari contends that human rights are an outdated myth. He calls for replacing them with a new global ethic to meet crises as varied as environmental destruction, disruptive technologies, and extreme gaps between rich and poor. Toward that end, he outlines an ethics that exalts compassion and elides justice, an ethics that animates his trilogy: Sapiens, Homo Deus, and 21 Lessons for the 21st Century. I draw together the key elements in his personal ethics, tracing them to a combination of scientism, postmodernism, and Buddhism. I then argue that he misunderstands human rights, inflates the role of science in moral matters, and fails to reconcile his moral passion with his moral skepticism.
The Intensive Other: Deleuze and Levinas on the Ethical Status of the Other
Authors: Ventura David 
Published: June 2020

AbstractThis paper develops a response to the ethical conception of the human Other formulated by Gilles Deleuze in his review of Michel Tournier’s 1967 novel Friday. The central contention here is that although Deleuze develops a compelling notion of intensive ethics in response to Tournier’s novel, that ethics also remains deeply problematic in refusing to ascribe a positive role to the human Other. My wager is that some of these problems can be brought to light by placing Deleuze’s philosophy in dialogue with that of Emmanuel Levinas. As I seek to show, Levinas’s philosophy of alterity not only reveals that Deleuze is mistaken in failing to ascribe a positive ethical role to the human Other, but also begins to point the way toward a more positive conception of ethics that does not oppose the Other to the intensive realm that Deleuze so much values.
Barley HISTIDINE KINASE 1 (HvHK1) coordinates transfer cell specification in the young endosperm
Authors: Hertig Christian , Melzer Michael , Rutten Twan , Erbe Stephan , Hensel Götz , Kumlehn Jochen , Weschke Winfriede , Weber Hans , Thiel Johannes 
Published: June 2020

SUMMARYCereal endosperm represents the most important source of the world’s food; nevertheless, the molecular mechanisms underlying cell and tissue differentiation in cereal grains remain poorly understood. Endosperm cellularization commences at the maternal–filial intersection of grains and generates endosperm transfer cells (ETCs), a cell type with a prominent anatomy optimized for efficient nutrient transport. Barley HISTIDINE KINASE1 (HvHK1) was identified as a receptor component with spatially restricted expression in the syncytial endosperm where ETCs emerge. Here, we demonstrate its function in ETC fate acquisition using RNA interference‐mediated downregulation of HvHK1. Repression of HvHK1 impairs cell specification in the central ETC region and the development of transfer cell morphology, and consecutively defects differentiation of adjacent endosperm tissues. Coinciding with reduced expression of HvHK1, disturbed cell plate formation and fusion were observed at the initiation of endosperm cellularization, revealing that HvHK1 triggers initial cytokinesis of ETCs. Cell‐type‐specific RNA sequencing confirmed loss of transfer cell identity, compromised cell wall biogenesis and reduced transport capacities in aberrant cells and elucidated two‐component signaling and hormone pathways that are mediated by HvHK1. Gene regulatory network modeling was used to specify the direct targets of HvHK1; this predicted non‐canonical auxin signaling elements as the main regulatory links governing cellularization of ETCs, potentially through interaction with type‐B response regulators. This work provides clues to previously unknown molecular mechanisms directing ETC specification, a process with fundamental impact on grain yield in cereals.
An Improved Phenotype-Genotype Mapping for Solving Selective Assembly Problem Using Evolutionary Optimization Algorithms
Authors: Rezaei Aderiani Abolfazl , Wärmefjord Kristina , Söderberg Rikard 
Published: June 2020

Abstract
Selective assembly is an assembly technique for producing high-quality assemblies from relatively lower quality mating parts. Developing the application of this technique to sheet metal assemblies in the automotive industry can improve the geometrical quality and reduce production costs significantly. Nevertheless, the required calculation time is the main obstacle against this development. To apply a selective assembly technique, an optimization problem of finding the optimal combination of mating parts should be solved. This problem is an MINLP optimization problem for selective assembly of sheet metals. This paper demonstrates that the phenotype-genotype mapping commonly used in most conventional selective assembly studies enlarges the search domain of the optimization. Thereafter, a new approach that makes the mapping one-to-one is proposed and applied to three selective assembly sample cases from the literature. Moreover, it is indicated that meta-heuristic methods are superior to MILP and MINLP methods in solving this problem, particularly for assemblies of more than two components and relatively large batch sizes. The results evidence that using the new method improves the convergence rate of meta-heuristics in solving the problem by reducing the number of cost function evaluations to 45% for sheet metal assemblies. This means reducing up-till 26 h of the optimization time for the presented sample cases.