bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testosterone Effects on Short-Term Physical, Hormonal, and Neurodevelopmental Outcomes in Infants with 47,XXY/Klinefelter Syndrome: The TESTO Randomized Controlled Trial
Authors: Davis Shanlee , Howell Susan , Janusz Jennifer , Lahlou Najiba , Reynolds Regina , Thompson Talia , Swenson Karli , Wilson Rebecca , Ross Judith , Zeitler Philip , Tartaglia Nicole 
Published: December 2024

ABSTRACTContext47,XXY/Klinefelter syndrome (XXY) is associated with impaired testicular function and differences in physical growth, metabolism, and neurodevelopment. Clinical features of XXY may be attributable to inadequate testosterone during the mini-puberty period of infancy.ObjectiveWe tested the hypothesis that exogenous testosterone treatment positively effects short-term physical, hormonal, and neurodevelopmental outcomes in infants with XXY.DesignDouble-blind randomized controlled trial, 2017-2021SettingUS tertiary care pediatric hospitalPatientsInfants 30-90 days of age with prenatally identified, non-mosaic 47,XXY (n=71).InterventionTestosterone cypionate 25mg intramuscular injections every 4 weeks for 3 dosesMain outcome measuresThea prioriprimary outcomes were change in percent fat mass (%FM) z-scores and change in the total composite percentile on Alberta Infant Motor Scales (AIMS) assessment from baseline to 12 weeks.ResultsThe between group difference in change in %FM z-scores was -0.57 [95% CI -1.1, - 0.06], p=0.03), secondary to greater increases in lean mass in the testosterone-treated group (1.5±0.4 kg vs 1.2±0.4, p=0.001). Testosterone suppressed gonadotropins and inhibin B (p<0.001 for all). In contrast, there were no significant group differences in short term motor, cognitive, or language outcomes (p>0.15 for all).ConclusionsIn this double-blind randomized controlled trial in infants with XXY, testosterone injections resulted in physical effects attributable to systemic androgen exposure; however, there was no impact on neurodevelopmental outcomes and the hypothalamic-pituitary-gonadal axis was suppressed. These results do not support routine testosterone treatment in infants with XXY, however long term follow up on physical health, neurodevelopment and testicular function is needed.
Integration of Elemental Imaging and Spatial Transcriptomic Profiling for Proof-of-Concept Metals-Based Pathway Analysis of Colon Tumor Microenvironment
Authors: Srivastava Aruesha , Shaik Neha , Lu Yunrui , Chan Matthew , Diallo Alos , Han Serin , Punshon Tracy , Jackson Brian , Vahdat Linda , Liu Xiaoying , Mittal Vivek , Lau Ken , Gui Jiang , Vaickus Louis , Hoopes Jack , Kolling Fred , Perreard Laurent , Marotti Jonathan , Levy Joshua 
Published: December 2024

AbstractThe complex interplay between metal abundance, transport mechanisms, cell distribution, and tumor progression-related biological pathways (e.g., metabolism, collagen remodeling) remains poorly understood. Traditionally, genes and metals have been studied in isolation, limiting insights into their interactions. Recent advances in spatial transcriptomics and elemental profiling now enable comprehensive exploration of tissue-wide metal-gene interactions, though integration remains challenging. In this proof-of-concept study, we investigated metal-dependent signaling within the tumor microenvironment of a unique colorectal cancer (CRC) tumor. We implemented a spatial multimodal workflow which integrated elemental imaging, gene expression, cellular composition, and histopathological features to uncover metals-related pathways through spatially resolved differential expression analysis. Preliminary findings revealed significant associations, for instance: elevated iron correlated with mesenchymal phenotypes located at the tumor’s proliferative front, reflecting epithelial-to-mesenchymal transition pathways, and extracellular matrix remodeling. High concentrations of copper were predominantly localized in regions of active tumor growth and associated with the upregulation of immune response genes. This proof-of-concept workflow demonstrates the feasibility of integrating elemental imaging with spatial transcriptomics to identify metals-based gene correlates. Future application of this workflow to larger patient cohorts will pave the way for expansive comparisons across the metallome and transcriptome, ultimately identifying novel targets for tumor progression biomarkers and therapeutic interventions.
A simple analytical model for predicting locomotive ground reaction forces in foals
Authors: Opolz Melany D. , Moshage Sara G. , McCoy Annette M. , Kersh Mariana E. 
Published: December 2024

AbstractEquine models are useful in biomechanics research of locomotion due to their similarity in musculoskeletal tissue to humans, their athletic nature, and rapid skeletal development which permits ontogenetic studies. However, a continuing challenge in musculoskeletal models for large animal biomechanics is measuring the ground reaction force (GRF) during locomotion. This gap has resulted in a lack of reporting of gait measures such as joint torques. Here we propose an analytical method for predicting ground reaction forces in foals (growing horses) based on the Froude number. Motion capture, GRF, and subject mass data during walking and trotting gaits were collected longitudinally. To account for differences in subject size, we calculated the dimensionless Froude number (Fr=v2/(g*l)). The walk-trot transition speed occurred near Fr=0.5, v=1.75-2.15 m/s and was consistent for all evaluated ages. Of the analytical regression models tested, linear regression models had the best performance for predicting vertical GRF data in foals with an average absolute error percent of 7.97% during trotting and 2.39% during walking, compared to a non-linear logistic model with an error of 8.38%. The model was converted to Python and implemented to predict GRF data for foals using the subject velocity and limb length as input. Our resulting analytical model can be used to estimate the GRF profile of equine gait enabling comparative studies of locomotion.
How to unravel the nature of the
Σ*(1430)(1/2−)
state from correlation functions
Authors: Li Hai-Peng , Xiao Chu-Wen , Liang Wei-Hong , Wu Jia-Jun , Wang En , Oset Eulogio 
Published: December 2024

We calculate the correlation functions for the K¯0p,π+Σ0,π0Σ+,π+Λ, and ηΣ+ states, which in the chiral unitary approach predict an excited Σ*(1/2−) state at the K¯N threshold, recently observed by the Belle Collaboration. Once this is done, we tackle the inverse problem of seeing how much information one can obtain from these correlation functions. With the resampling method, one can determine the scattering parameters of all the channels with relative precision, by means of the analysis in a general framework, and find a clear cusplike structure corresponding to the Σ*(1/2−) in the different amplitudes at the K¯N threshold.

Published by the American Physical Society
2024
Finding flavons at colliders
Authors: Abbas Gauhar , Kumar Alok Ashutosh , Chundawat Neetu Raj Singh , Khan Najimuddin , Singh Neelam 
Published: December 2024

We conduct a comprehensive investigation into the flavor phenomenology and collider signatures of flavon of ZN×ZM flavor symmetries for the soft symmetry-breaking scenario and a new symmetry-conserving mechanism at the high-luminosity LHC, high-energy LHC, and a 100 TeV hadron collider. The flavor physics of quark and leptonic observables places different bounds on the parameter space of flavons of ZN×ZM flavor symmetries. On the collider side, the decay t→ca can be probed by the high-luminosity LHC, high-energy LHC, and a 100 TeV hadron collider for the Z8×Z22 flavor symmetry. The inclusive production signatures can be used to probe the flavon of all the ZN×ZM flavor symmetries for the soft symmetry-breaking scenario for a heavy flavon at a 100 TeV collider. Flavons of all the ZN×ZM flavor symmetries can be probed at high-energy LHC and a 100 TeV collider for a low mass in the case of soft symmetry breaking. The diflavon production is within reach of the high-luminosity LHC, high-energy LHC, and a 100 TeV collider only for a light flavon. The 14 TeV high-luminosity LHC can probe only the Z2×Z5 and Z8×Z22 flavor symmetries for a few specific inclusive signatures. The symmetry-conserving scenario remains beyond the detection capabilities of any collider.

Published by the American Physical Society
2024
A multi-criteria approach to egress location selection in buildings: integrating economic, technical and social factors
Authors: Alac Ruken , Hammad Ahmed W.A. , Hadigheh Ali , Opdyke Aaron 
Published: December 2024

PurposeThis paper aims to introduce an innovative decision-making framework designed to optimize egress location selection in buildings, significantly enhancing safety during emergencies. By integrating social, economic and technical criteria through the fuzzy analytic hierarchy process (F-AHP), this framework effectively manages the uncertainties inherent in emergency scenarios, providing a robust tool for safeguarding lives and property.Design/methodology/approachThe proposed methodology employs the F-AHP to systematically integrate and evaluate social, economic and technical criteria for egress location selection. A comprehensive case study conducted on a one-story school building demonstrates this approach’s practical application and effectiveness.FindingsThe analysis reveals that economic criteria are the most significant in determining the optimal egress location, constituting 61.9% of the overall weight, followed by technical criteria at 26.8% and social criteria at 11.3%. The findings highlight the practical application and effectiveness of the proposed approach in addressing uncertainties and optimizing egress location selection. Integrating social, economic and technical considerations gives decision-makers a robust tool to optimize safety, cost-effectiveness and evacuation efficiency.Practical implicationsThe findings underscore the practical benefits and effectiveness of the proposed approach in managing uncertainties and improving the selection of optimal egress locations. Integrating social, economic and technical considerations gives decision-makers a robust tool to optimize safety, cost-effectiveness and evacuation efficiency. This approach equips practitioners with a comprehensive framework for enhancing emergency preparedness and resilience in various building scenarios.Originality/valueThis research introduces a novel framework for egress location selection that addresses the limitations of existing studies by integrating multiple criteria – social, economic and technical – into a cohesive decision-making process. Using the F-AHP in a case study illustrates the framework’s practicality and adaptability, providing a dynamic solution that enhances the overall effectiveness of emergency plans. By prioritizing safety, cost-effectiveness and efficiency, this framework ensures that emergency plans are robust and adaptable, thereby significantly enhancing resilience in the face of emergencies.
Integrating UPnP technology with CAFM systems – automated device identification and device control in building operation and maintenance
Authors: Gärtner Asbjörn , Kurzrock Björn-Martin 
Published: December 2024

Purpose
Modern buildings use intelligent automation for comfort, efficiency and sustainability, impacting their construction and operation. Although building automation (BA) operates via bus lines and is controlled by sensors and actuators, computer-aided facility management (CAFM) systems often handle data redundantly. Current standards fail to detail effective systems integration, with a noticeable gap in practical network models and solutions.The purpose of this paper is to design a network model that integrates building services and networks at the automation level. The goal is to enable the CAFM side to control all electrical loads (such as lighting, blinds, pumps), climate control (HVAC) and security monitoring.

Design/methodology/approach
This paper explores the automatic discovery and integration of BA devices and centralized controls into CAFM systems, focusing on innovative networking models, system data provisioning, import functions and web operation. Established technologies such as Universal Plug and Play (UPnP) and Extensible Markup Language (XML) standards are utilized to develop new solutions.

Findings
The paper introduces a solution with a database and software module enabling bidirectional web-based coupling via LAN. The UPnP standard was enhanced to include facility management (FM)–specific information for device communication. The prototype effectively controls devices through CAFM systems, setting a foundation for future improvements in web-based BA. These results are crucial for developing standards for automated data processing between CAFM systems and BA.

Practical implications
This research benefits FM, especially in maintenance, operations, energy and compliance. In addition, the need for time-consuming on-site inspections to record device master data for maintenance management, in case of commissioning or changing facility service providers, can be eliminated. The principles of the developed software module enhance CAFM systems as high-performance building control tools.

Originality/value
The paper adapts existing technologies for specific FM applications and integrates them for the first time into key FM processes.
Unlocking sustainable partnerships: exploring the willingness of oil palm producers to engage in contract farming initiatives
Authors: Wongnaa Camillus Abawiera , Addai Peter , Quainoo Prince , Ohene-Yankyera Kwasi , Tham-Agyekum Kwame Enoch , Awunyo-Vitor Dadson 
Published: December 2024

PurposeThis study examined the factors influencing oil palm farmers’ decisions to engage in contract farming as well as their extent of participation.Design/methodology/approachThe study used cross-sectional data collected from 210 oil palm producers in the western region of Ghana. Descriptive statistics and Cragg’s double hurdle model were the methods of analysis.FindingsThe results showed that household size, membership of farmer association, farm size, market knowledge and loan availability significantly positively influence farmers’ decisions to engage in contract farming. Also, while membership in farmer associations and market knowledge exerted significant positive influences on the extent to which farmers participated in contract farming, extension contacts and distance to the farm exerted significant negative influences on the extent of farmers’ participation.Practical implicationsThe government, in collaboration with other interested parties, should educate and encourage farmers on the benefits of participating in contract farming arrangements with reputable and well-known institutions that have taken steps to make their services available to farmers.Social implicationsThe study recommends that the government and other contracting firms, like the Golden Star Oil Palm Plantation, should make farm credit a key aspect of their packages, as this will be more attractive to the smallholders.Originality/valueThe study adds to existing literature by providing contracting companies with helpful information on factors influencing oil palm farmers’ decisions to engage in contract farming.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-03-2024-0284
Knowledge base and innovative practices: analysis of the moderating effect of network competence. An application in the Alicante wine industry
Authors: Expósito-Langa Manuel , Tomás-Miquel José-Vicente , Fotă Andreea-Elena 
Published: December 2024

Purpose
This study aims to contribute to the debate on the firm’s innovative determinants. Drawing on the relevance of internal resources, such as the knowledge base, in developing the innovative practices, it also considers the multiplier effect of network competence, defined as the ability to develop and consciously manage relationships with other actors in the territory.

Design/methodology/approach
The study is based on data obtained from personal interviews with managers and oenologists from the wineries that adhered to the Protected Designation of Origin in the Alicante province/region.

Findings
The results confirm the positive effect of the knowledge base. In addition, it shows that increased competence in managing the firm’s relational context allows it to obtain external knowledge inputs, which, combined with internal knowledge, benefits its innovative practices.

Originality/value
This study contributes to a better understanding of how companies can improve their innovation by combining internal knowledge with developing and strengthening links with other agents in the territory.
Developmental milestones and terrorism: age-linked variations in risk assessment
Authors: Kenyon Jonathan , Simpson Kris 
Published: December 2024

Purpose
Against a backdrop of an increasingly younger terrorist cohort within His Majesty’s Prison and Probation Service, this study aims to explore the relationship between age and various Extremism Risk Guidance 22+ (ERG22+) assessment outcomes.

Design/methodology/approach
A database of 490 individuals was developed by coding content of ERG22+ reports from 2010 to 2021, equating to nearly all cases in England and Wales across this time period. Socio-demographic information, offending histories, online activities and risk factors were coded for all individuals. This study focuses on 465 individuals convicted of terrorist/terrorist-related offending, with statistical analyses used to compare three age groups: “20 and under” (61 cases), 21–25 (133 cases) and “26 and over” (271 cases).

Findings
Significant associations were found between presence of certain behaviours/characteristics and age groups. For those aged 20 and under, a heightened propensity for excitement, comradeship and adventure, along with greater susceptibility to influence and need for status were generally key to offending pathways, with a diminished likelihood of a prior criminal history. Of the three ERG22+ dimensions, findings indicate a weak but significant negative correlation between age and engagement levels.

Practical implications
Recommendations include ensuring extremism risk assessments reflect age-specific behaviours and tendencies, that interventions are tailored to address common age-related vulnerabilities, and the need for age-specific policies to support and manage children and young adults within the counter-terrorism space.

Originality/value
These novel findings point towards notable developmental milestones in adolescence, affecting behavioural tendencies and risk. This underscores the importance of age as a determinant when interpreting extremism risk assessments.
Examining CSR communication on social media during a victim crisis: a machine learning based text analytics approach
Authors: Yang Jing , Basile Kelly , Zhao Xiaowei 
Published: December 2024

PurposeThis study examines how top global brands changed their corporate social responsibility (CSR) communication on social media during a victim crisis, and how their CSR communication on social media influenced consumer sentiment.Design/methodology/approachUsing 18,502 firms’ Facebook posts and their most relevant consumer comments from pre-pandemic and during-pandemic timeframes, this study integrates machine learning techniques (BERTopic) with human-based qualitative analysis to analyze CSR posts. It also measures the polarity and magnitude of consumer sentiment with Google Natural Language AI. We tested seven hypotheses using Hierarchical Linear Modeling (HLM).FindingsThe machine learning-based topic modeling analysis showed that firms increased CSR communications intensity on social media and they more intentionally chose different CSR communication strategies for different topics on social media during the victim crisis. The hypothesis testing results show proactive, accommodative and interactive strategies have a significant impact on consumer sentiment polarity and magnitude, and these effects are moderated by the level of interactivity and industry type.Originality/value(1) This study takes a dynamic view to examine the firms’ CSR communication on social media during a victim crisis. It used machine learning-based text analytics and found many interesting results on how firms changed their CSR communication topics and strategies on social media during the crisis. (2) It measures both consumer sentiment polarity and sentiment magnitude to conduct sentiment analysis. The results indicate that the CSR communication strategies have different impacts on the two sentiment components. (3) It integrates machine learning techniques with human-based qualitative analysis. It shows how researchers can gain the benefits of both approaches.
Industry 5.0 – the human centric solution and personalization: challenges and opportunities for libraries
Authors: Ashiq Murtaza 
Published: December 2024

Purpose
Industry 5.0 is considering a paradigm shift from mass production to mass personalization and a human-centric model of services using modern technologies. This study aims to examine the Industry 5.0 and its applications in various sectors. It also pinpoints the possible challenges and opportunities for libraries promoting library services, resources, infrastructure and spaces to attract the modern library users.

Design/methodology/approach
Relevant literature on the topic was searched using keywords including Industry 5.0, modern technologies, artificial intelligence, sustainability and green shift and libraries. The researcher also used his experience and the initiatives of the Punjab University Library, which is the oldest and largest university in Pakistan, to promote personalization and user-centered approaches.

Findings
Findings revealed challenges and opportunities for libraries. Using Industry 5.0, Libraries have the potential to understand users’ preferences, browsing history and information behavior, and accordingly design their services, resources, infrastructure and spaces. Libraries can serve their modern users through personalization and human centric approach such as content recommendations, alert and notification services, customized research assistant, inclusive and accessibility services, personalized event services and personalization through human books.

Practical implications
Professional library associations, library schools, library directors and libraries need to proactive learn and apply Industry 5.0 while establishing library services, resources, infrastructure and spaces. Library schools need to design their curriculum considering the Industry 5.0 technologies, tools, and platforms.

Originality/value
This study provides a pen picture of the Industry 5.0 and its impact on libraries. Potential challenges and opportunities are highlighted. These all initiatives required a visionary library leadership to take initiatives toward human-centered personalized services and attract the modern library users.