bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Application of 3D Printing Technology in the Classification and Preoperative Planning of Complex Tibial Plateau Fractures
Authors: Chen Fuyang , Huang Chenyu , Ling Chen , Zhou Jinming , Wang Yufeng , Zhang Po , Jiang Xiao , Xu Xiaoming , Jian Jian , Wang Liming , Yao Qingqiang 
Published: August 2020

Abstract
Background: Tibial plateau fracture is one of the common intra-articular fractures in clinic. And its accurate classification and treatment is a difficult problem for orthopedic surgeons. Our research aims to investigate the application value of 3D printing in the classification and preoperative planning of complex tibial plateau fractures.Methods: 28 cases of complex tibial plateau fractures diagnosed and treated in our hospital from January, 2017 to January, 2019.01 were analyzed. Preoperative spiral CT scan was performed and then DICOM data were input into the computer. We use Mimics to process data. And 3D printing technology was applied to print the 3D model of fracture (1:1). Combined with the 3D printed model, the tibial plateau fractures were subdivided into seven types according to the geometric plane of the tibial plateau. The surgical approach was determined on the 3D printed model. And then simulated operations such as accurate reduction of fracture and selection of plate placement were performed.Results: The reconstructed 3D model of tibial plateau fracture can accurately reflect the direction of fracture displacement and the degree of plateau collapse. Also, it and can help with the preoperative surgical design of tibial plateau fracture. The intraoperative fracture details were basically the same as the 3D printed model. And the fracture surface of the tibial plateau was well improved in all 28 cases.Conclusion: 3D printing technology can be used to guide the classification and preoperative planning of complex tibial plateau fractures.
Increased Incidence of Susac Syndrome: A Case Series Study
Authors: Wilf-Yarkoni Adi , Elkayam O. , Aizenstein O. , Yahav O. , Furer V. , Zur D. , Goldstein M. , Barequet D. , Hallevi H. , Karni A. , Habot-Wilner Z , Regev K 
Published: August 2020

Abstract
BackgroundSusac syndrome (SuS) is a rare condition characterized by a clinical triad of sensorineural hearing loss, branch artery occlusion and encephalopathy. This study reports an increased incidence of SuS in Israel. We describe the clinical characteristics of these patients, diagnostic procedures and the use and subsequent outcomes of newly published treatment guidelines. MethodsThis is a single center retrospective study. Patients who were diagnosed with SuS between July 2017 and August 2018 were enrolled in this study. ResultsSeven patients were diagnosed with SuS according to the diagnostic criteria in a time period of 13 months. The annual incidence was recently evaluated in Austria to be 0.024/100000, therefore, our case series represent at least a 5.4- fold increase in the annual incidence of SuS expected in Israel and a 7-fold increase in the annual incidence expected in our medical center. Mean time from the onset of the symptoms to diagnosis was three weeks and follow-up time was twenty four months. Recent exposure to cytomegalovirus was serologically evident in three patients and one patient had high titer of anti-streptolysin antibody. All patients underwent brain MRI, fluorescein angiography and audiometry. All patients were treated according to the newly recommended guidelines. All patients achieved clinical and radiological stability. ConclusionsWe report of an increased incidence of SuS in Israel. Infectious serological findings may imply a post infectious mechanism. The use of the recommended diagnostic procedures reduced the time to diagnosis. Newly published treatment guidelines led to favorable clinical outcomes.
Effects of brewers’ spent grain protein hydrolysates on gas production, ruminal fermentation characteristics, microbial protein synthesis and microbial community in an artificial rumen fed a high grain diet
Authors: Ran Tao , Jin Long , Abeynayake Ranithri , Saleem Atef Moohanmed , Zhang Xiumin , Niu Dongyan , Chen Lingyun , Yang Wenzhu 
Published: August 2020

Abstract
Background

Brewers’ spent grain (BSG) typically contains 20 ~ 29% crude protein (CP) with high concentrations of glutamine, proline and hydrophobic and non-polar amino acid, making it an ideal material for producing value-added products like bioactive peptides which have antioxidant properties. For this study, protein was extracted from BSG, hydrolyzed with 1% alcalase and flavourzyme, with the generated protein hydrolysates (AlcH and FlaH) showing antioxidant activities. This study evaluated the effects of AlcH and FlaH on gas production, ruminal fermentation characteristics, nutrient disappearance, microbial protein synthesis and microbial community using an artificial rumen system (RUSITEC) fed a high-grain diet.

Results

As compared to the control of grain only, supplementation of FlaH decreased ( P < 0.01) disappearances of dry matter (DM), organic matter (OM), CP and starch, without affecting fibre disappearances; while AlcH had no effect on nutrient disappearance. Neither AlcH nor FlaH affected gas production or VFA profiles, however they increased ( P < 0.01) NH 3 -N and decreased ( P < 0.01) H 2 production. Supplementation of FlaH decreased ( P < 0.01) the percentage of CH 4 in total gas and dissolved-CH 4 (dCH 4 ) in dissolved gas. Addition of monensin reduced ( P < 0.01) disappearance of nutrients, improved fermentation efficiency and reduced CH 4 and H 2 emissions. Total microbial nitrogen production was decreased ( P < 0.05) but the proportion of feed particle associated (FPA) bacteria was increased with FlaH and monensin supplementation. Numbers of OTUs and Shannon diversity indices of FPA microbial community were unaffected by AlcH and FlaH; whereas both indices were reduced ( P < 0.05) by monensin. Taxonomic analysis revealed no effect of AlcH and FlaH on the relative abundance (RA) of bacteria at phylum level, whereas monensin reduced ( P < 0.05) the RA of Firmicutes and Bacteroidetes and enhanced Proteobacteria. Supplementation of FlaH enhanced ( P < 0.05) the RA of genus Prevotella , reduced Selenomonas , Shuttleworthia , Bifidobacterium and Dialister as compared to control; monensin reduced ( P < 0.05) RA of genus Prevotella but enhaced Succinivibrio .

Conclusions

The supplementation of FlaH in high-grain diets may potentially protect CP and starch from ruminal degradation, without adversely affecting fibre degradation and VFA profiles. It also showed promising effects on reducing CH 4 production by suppressing H 2 production. Protein enzymatic hydrolysates from BSG using flavourzyme showed potential application to high value-added bio-products.
The variation tendency of serum C-reactive protein is a good marker to predict postoperative complications after laparoscopic gastrectomy for adenocarcinoma of esophagogastric junction
Authors: Luo Bin , Liao Qianchao , Zheng Jiabin , Hu Weixian , Yao Xueqing , Cai Guanfu , Li Yong , Wang Junjiang 
Published: August 2020

Abstract
Background: Postoperative complications (PCs) after laparoscopic gastrectomy with mediastinal lymph nodes resection for adenocarcinoma of esophagogastric junction (AEG) prolonged the time of hospitalization and increased mortality rate. Early diagnosis of PCs was of great importance. This retrospective study aimed to investigate whether the variation tendency of serum C-reactive protein can be used as an early marker to predict major postoperative complications after laparoscopic gastrectomy for AEG.Methods: Data for patients underwent laparoscopic gastrectomy for AEG, from January 2015 to March 2020, were retrospectively analyzed. The area under the receiver operating characteristic (ROC) curve (AUC) was used to determine diagnostic accuracy of inflammatory markers. The optimal cutoff values were calculated by maximizing Youden’s index. Univariate and multivariate logistic regression analyses were performed to identify risk factors for PCs of grade III or more，according to the Clavien-Dindo classification. Results: A total of 114 patients were analyzed, of whom 21 (18.4%, 95% CI 11.4-25.4 %) developed major PCs, including anastomotic leakage in 13. The ratio of CRP level on postoperative day 3 to day 2 (POD3/2 CRP) provided the best diagnostic accuracy (AUC 0.903, 95% CI 0.814-0.993, p＜0.001). Proximal gastrectomy (OR 8.224, 95% CI 1.976-34.234, p=0.004) and operation time ≥360 minutes (OR 6.753, 95% CI 2.037-22.395, p=0.002) were identified as significant independent risk factors for major PCs.Conclusions: The POD3/2 CRP was the best marker to predict PCs after laparoscopic gastrectomy for AEG.
Frequency Ratio Density, Logistic Regression and Weights of Evidence Modelling for Landslide Susceptibility Assessment and Mapping in Yanase and Naka Catchments of Southeast Shikoku, Japan
Authors: Meten Matebie , Bhandary Netra Prakash 
Published: August 2020

Abstract
Landslide susceptibility assessment is an important tool for disaster management and development activities. Shikoku Island in the southwest Japan is one of the most landslide prone areas due to heavy typhoon rainfall, complex geology and the presence of mountainous areas and low topographic features (valleys).Yanase and Naka Catchments of Shikoku Island in Japan were chosen as a study area. The objective of this study is to apply Frequency Ratio Densisty (FRD), Logistic Regression (LR) and Weights of Evidence (WoE) models in a GIS environment to prepare the landslide susceptibility maps of this area and select the best one for future infrastructure and landuse planning. Data layers including slope, aspect, profile curvature, plan curvature, lithology, land use, distance from river, distance from fault and annual rainfall were used in this study. In FR method, two models were attempted but the FRD model was found slightly better in its performance. In case of LR method, two models, one with equal proportion and the other with unequal proportion of landslide and non-landslide points were applied and the one with equal proportions was chosen based on its highest performance. A total of five landslide susceptibility maps(LSMs) were produced using FR, LR and WoE models resulting two, two and one LSMs respectively. However, one best model was chosen from the FR and LR methods based on the highest area under the curve (AUC) of the receiver operating characteristic (ROC) curves. This reduced the total number of landslide susceptibility maps to three with the success rates of 86.7%, 86.8% and 80.7% from FRD, LR and WoE models respectively. For validation purpose, all landslides were overlaid over the three landslide susceptibility maps and the percentage of landslides in each susceptibility class was calculated. The percentages of landslides that fall in the high and very high susceptibility classes of FRD, LR and WoE models showed 82%, 84% and 78% respectively. This showed that the LR model with equal proportions of landslides and non-landslide points was slightly better than FRD and WoE models in predicting the probability of future landslide occurrence.
On Jones et al.’s Method for Assessing Limits of Agreement with the Mean for Multiple Observers
Authors: Christensen Heidi S. , Borgbjerg Jens , Børty Lars , Bøgsted Martin 
Published: August 2020

Abstract
Background To assess the agreement of continuous measurements between a number of observers, Jones et al. introduced limits of agreement with the mean (LOAM) for multiple observers, representing how much an individual observer can deviate from the mean measurement of all observers. Besides the graphical visualisation of LOAM, suggested by Jones et al., it is desirable to supply LOAM with confidence intervals and to extend the method to the case of multiple measurements per observer.Methods We reformulate LOAM under the assumption the measurements follow an additive two-way random effects model. Assuming this model, we provide estimates and confidence intervals for the proposed LOAM. Further, this approach is easily extended to the case of multiple measurements per observer.Results The proposed method is applied on two data sets to illustrate its use. Specifically, we consider agreement between measurements regarding tumour size and aortic diameter. For the latter study, three measurement methods are considered. Conclusions The proposed LOAM and the associated confidence intervals are useful for assessing agreement between continuous measurements.
Contralateral hemisphere as a lifeguard which is supported by melatonin for molecular and functional recovery after stroke
Authors: Kilic Ulkan , Elibol Birsen , Caglayan Ahmet Burak , Beker Mustafa Caglar , Beker Merve , Altug-Tasa Burcugul , Uysal Omer , Yilmaz Bayram , Kilic Ertugrul 
Published: August 2020

Abstract
Successful functional recovery from stroke is crucial in the rehabilitation of patients and mainly depends on several ischemia-induced processes, including cell survival and apoptosis. Melatonin is an interesting candidate for secondary stroke prevention due to its effect on signaling pathways. Therefore, we investigated the coordination of ipsilateral and contralateral hemispheres to evaluate delayed post-acute effect of melatonin on recovery of the cell survival and apoptosis after stroke. Melatonin was administered (4 mg/kg/day) intraperitoneally for 45 days, starting 3-day after 30-min of middle cerebral artery occlusion. The genes and proteins related to the cell survival and apoptosis were investigated by immunofluorescence, western blotting and RT-PCR techniques after behavioral experiments. Melatonin produced delayed neurological recovery by improving motor coordination, which was also reflected by enhanced neuronal survival and reduced apoptosis in the post-acute phase of stroke in both contralateral and ipsilateral hemispheres. The increase of NGF, Nrp1, c-jun; activation of AKT; and dephosphorylation of ERK and JNK at the 55th day showed that cell survival and apoptosis signaling molecules compete to contribute to the remodeling of brain. Furthermore, an increase in the CREB and Atf-1 expressions suggested the melatonin's strong reformative effect on neuronal regeneration. The contralateral hemisphere was more active at the latter stages of the molecular and functional regeneration which provides a further proof of principle about melatonin's action on the promotion of brain plasticity and recovery after stroke.
Effects of effort-reward imbalance, job satisfaction, and work engagement on self-rated health among healthcare workers
Authors: Ge Jingjing , He Jing , Liu Yan , Zhang Juying , Pan Jingping , Zhang Xueli , Liu Danping 
Published: August 2020

Abstract
Background
Healthcare workers, who protect and improve the health of individuals, are critical to the success of health systems and achieving national and global health goals. To respond effectively to the healthcare needs of populations, healthcare workers themselves must be in a perfect state of health. However, healthcare workers face various psychosocial pressures, including having to work night shifts, long working hours, demands of patient care, medical disputes, workplace violence, and emotional distress due to poor interactions with patients and colleagues, and poor promotion prospects. Constant exposure to these psychosocial hazards adversely impacts healthcare workers’ health. Consequently, this study aimed to examine the influence of effort-reward imbalance, job satisfaction, and work engagement on self-rated health of healthcare workers. The results would be conducive to providing policy guidance to improve the health of healthcare workers.
Methods
We analysed the data of 1327 participants from The Chinese Sixth National Health and Services Survey in Sichuan Province that was conducted from August 2018 to October 2018. Structural equation modelling was used to test the hypothesized relationships among the variables.
Results
Only 40.1% of healthcare workers rated their health as ‘relatively good’ or ‘good’. Effort-reward imbalance had a significant negative correlation with self-rated health (β = -0.053, 95% CI [-0.163, -0.001]). The associations of effort-reward imbalance and work engagement with self-rated health were both mediated by job satisfaction (95% CI [-0.150, -0.050] and [0.011, 0.022]), and work engagement mediated the relationship between effort-reward imbalance and self-rated health (95% CI [-0.064, -0.008]).
Conclusion
In order to improve the health of healthcare workers, administrators should balance effort and reward and provide opportunities for career development and training. In addition, health managers should help healthcare workers realize the significance and value of their work and keep them actively devoted to their work through incentive mechanisms.
The effectiveness of preoperative rehabilitation programmes on postoperative outcomes following anterior cruciate ligament (ACL) reconstruction: a systematic review.
Authors: Carter Hayley , Littlewood Chris , Webster Kate , Smith Benjamin 
Published: August 2020

Abstract
Background To explore the effectiveness of preoperative rehabilitation programmes (PreHab) on postoperative physical and psychological outcomes following anterior cruciate ligament reconstruction (ACLR). Method A systematic search was conducted from inception to November 2019. Randomised controlled trials (RCTs) published in English were included. Risk of bias was assessed using Version 2 of the Cochrane risk-of-bias tool, and the Grading of Recommendations Assessment system was used to evaluate the quality of evidence. Results The search identified 739 potentially eligible studies, three met the inclusion criteria. All included RCTs scored ‘high’ risk of bias. PreHab in all three RCTs was an exercise programme, each varied in content (strength, control, balance and perturbation training), frequency (10 to 24 sessions) and length (3.1- to 6-weeks). Statistically significant differences (p<0.05) were reported for quadriceps strength (one RCT) and single leg hop scores (two RCTs) in favour of PreHab three months after ACLR. One RCT reported no statistically significant between-group difference for pain and function. No RCT evaluated post-operative psychological outcomes. Conclusion Low-quality evidence suggests that PreHab that includes muscular strength, balance and perturbation training offers a small benefit to quadriceps strength and single leg hop scores three months after ACLR. There is no consensus on the optimum PreHab programme content, frequency and length; this requires future consideration including the development of PreHab programmes that consider psychosocial factors and the measurement of relevant post-operative outcomes such as psychological readiness. PROSPERO trial registration number CRD42020162754
Unplanned hospital readmission after surgical treatment for thoracic spinal stenosis: incidence and causative factors
Authors: Wang Hui , Wang Longjie , Sun Zhuoran , Jiang Shuai , Li Weishi 
Published: August 2020

Abstract
Background: To assess the incidence and causative factors of unplanned hospital readmission within 90 days after surgical treatment of thoracic spinal stenosis (TSS).Methods: Hospital administrative database was queried to identify patients who underwent surgical treatment of TSS from July 2010 through December 2017. All unplanned readmissions within 90 days of discharge were reviewed for causes and the rate of unplanned readmissions was calculated. Patients of unplanned readmission were matched 1:3 to a control cohort without readmission.Results: Twenty-one patients (incidence of 1.7% in 1239 patients) presented unplanned hospital readmission within a 90-day period and enrolled as the study group, 63 non-readmission patients (a proportion of 1: 3) were randomly selected as the control group. Causes of readmission include CSF cyst (8 patients; 38%), CSF leakage combined with poor incision healing (6 patients; 29%), wound dehiscence (2 patient; 9%), surgical site infection (2 patients; 9%), spinal epidural hematoma (1 patient; 5%), inadequate original surgical decompression (2 patients; 9%). Mean duration from re-admission to the first surgery was 39.6 ± 28.2 days, most of the patients readmitted at the first 40 days (66.7%, 14/21 patients). When compared to the non-readmitted patients, diagnosis of OPLL + OFL, circumferential decompression, dural injury, long hospital stay were more to be seen in readmitted patients.Conclusions: The incidence of 90-day unplanned hospital readmission after surgical treatment of TSS is 1.7%, the peak period of readmission occurred from 10 to 40 days after surgery, CSF leakage and CSF cyst were the most common causes of unplanned hospital readmission.
WITHDRAWN: Antimicrobial activity of mouth rinses incorporating zein coated magnesium oxide nanoparticles
Authors: Naguib Ghada H , Hamed Mohamed T , Hatrom Abdulkarim A , Alnowaiser Abeer M , Bukhary Sahar MN , Hassan Ali H 
Published: August 2020

Abstract
Background The addition of antibacterial agents to oral prophylaxis materials showed inhibition of plaque accumulation and bacterial acid production. This study aimed to test the antimicrobial effect of distinctive oral mouth washes on an exemplary of oral bacteria after the addition of zein-coated MgO nanoparticles.Materials and Methods Three hundred and twelve groups were used in this study. MgO nanoparticles in five concentrations with zein and without zein-coating, were incorporated in three oral mouth washes: Listerine Zero, Listerine Total Control and Oral B in the mass percentages of 0.3%, 0.5%, 1%, 2%, 5% and 10%, in addition to controls with no MgO nanoparticles. The three mouthwashes with variable concentrations were studied in opposition of Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis and Candida albicans using two different tests, the Disc Diffusion Test (DDT) and Direct Contact Test (DCT). Data was analyzed with Kruskall-Wallis and Mann-Whitney U tests.Results Results showed a highly significant statistical difference of antimicrobial activity for all tested mouth washes with Zein coated MgO nanoparticles on Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Candida albicans in the disc diffusion test. While in the DCT, all tested mouth washes with MgO nanoparticles with and without zein coating showed antimicrobial activity on all tested microorganisms.Conclusion Zein coated MgO nanoparticles is a potent antimicrobial agent when added to oral mouth washes. It is recommended to incorporate Zein MgO nanoparticles to Oral mouth washes to improve its antibacterial property.
Investigations on Spectroscopic Properties of Manganese Ions in Sodium Lead Alumino Borate Glasses
Authors: karumuri Vijaya Babu , Vema Madhuri , Boddu Suresh 
Published: August 2020

Abstract
Divalent manganese ions containing 20Na2O-15PbO-(5-x)Al2O3-60B2O3:xMnO2 (x ranging from 0 to 1 mol%) NPAB glasses are prepared by using melt quenching technique and are characterized by several spectroscopic techniques. Various physical parameters are calculated from the measured density values. Structural properties of MnO2 doped NPAB glasses are investigated by Powder XRD, EPR, UV-VIS absorption and FT-IR spectroscopic techniques. The amorphous nature of prepared glass samples are confirmed by X- ray diffraction spectra. EPR spectra of these glasses exhibited a well resolved six line hyperfine structure around g = 2.00 is the characteristic nature of Mn(II) ions in distorted octahedral site symmetry. Optical absorption spectra of these glasses revealed a single broad band at  21000 cm-1 which has been assigned to the transition 6A1g(S) → 4T1g(G) of Mn(II) ions. Optical band gap energies and Urbach energies are evaluated through the fundamental Ultra Violet absorption edges of the glasses. FT-IR spectra clearly exhibited different vibrational bands and assigned to borate groups and water molecules.