bluuebunny/crossref_metadata_2025_split huggingface dataset:
An exploratory study of 89Zr-DFO-Atezolizumab ImmunoPET/CT in patients with locally advanced or metastatic renal cell carcinoma.
Authors: Bowman I. Alex , Dakanali Marianna , Mulgaonkar Aditi , Hammers Hans J. , Sun Xiankai , Oz Orhan K. , Brugarolas James 
Published: February 2020

TPS759 Background: Immune checkpoint inhibitors (ICIs) have changed the treatment landscape for renal cell carcinoma (RCC). Despite this, responses to single-agent anti-PD-1 occur in only 25% of patients. Biomarkers such as PD-L1 expression and tumor infiltrating lymphocyte density may predict response, but require invasive biopsies that fail to fully interrogate the complex tumor microenvironment throughout the patient. Efforts are underway to identify who will benefit from ICIs. Among these are the use of radiolabeled antibodies against PD-L1. We propose to combine the specificity of anti-PD-L1 antibodies with the sensitivity, resolution, and quantification offered by positron emission tomography to develop immunoPET (iPET). iPET will allow real-time monitoring of tumor and its microenvironment in-vivo, and may correlate with response and toxicity with ICIs. Methods: The anti-PD-L1 antibody Atezolizumab is conjugated to Zirconium-89 via desferrioxamine (DFO). 89Zr-DFO-Atezolizumab will be administered to two cohorts of approximately 20 patients. Cohort 1 have localized RCC prior to undergoing surgery, and cohort 2 have metastatic RCC prior to treatment with an ICI. The main exclusion criteria are existing use of an ICI or comorbidities that would preclude treatment with an ICI. All subjects will receive an IV injection of 89Zr-DFO-Atezolizumab followed 7 days (+/- 1 day) by a PET/CT scan. Subjects in cohort 2 will receive treatment with ICI per clinician discretion. Subjects will receive a repeat scan if disease recurrence is documented (cohort 1) or should progression or toxicity occur after treatment with an ICI (cohort 2). Biopsy of disease recurrence (cohort 1) will be standard, and encouraged for sites of disease progression on ICI (cohort 2). Co-primary endpoints are an exploratory analysis of 89Zr-DFO-Atezolizumab uptake on PET/CT with PD-L1 expression assessed by IHC in patients undergoing surgery (cohort 1) and to evaluate uptake across metastatic sites and explore the relationship with response or toxicity with ICI therapy (cohort 2). An investigational new drug approval has been granted for 89Zr-DFO-Atezolizumab (IND 143266) and accrual commenced 1 October 2019. Clinical trial information: NCT04006522.
The efficacy of music as a non-pharmacological intervention in the endoscopy setting: a literature review
Authors: Ware Dale , Habron John 
Published: February 2020

Background: Music has been demonstrated to have therapeutic effects for relaxation and pain management in various healthcare settings. However, this practice has not been adopted in the UK in the endoscopy environment. Music as an intervention could potentially lower pain thresholds, promote anxiolysis, reduce sedation and enhance the patient experience. Aims: The study aimed to identify, analyse and discuss existing knowledge on the topic of music medicine as an intervention in the endoscopy setting and to expose gaps in previous research and form recommendations for future research. Methods: Iterative searching of electronic databases, hand searches and grey literature searches were employed, following inclusion/exclusion criteria to identify relevant studies. Studies were then thematically analysed and themes identified. Findings: The search identified 11 relevant studies, with emergent themes of anxiety, patient satisfaction, sedation/analgesia, choice of music and procedure times. Conclusions: This literature review showed that music is a safe therapeutic intervention. It has the potential to act as an anxiolytic, reducing amounts of sedation or even replacing sedation in some cases. Patient satisfaction and experience can be enhanced, reducing DNA rates and encouraging greater uptake of repeat procedures.
Spinal sagittal alignment and head control in patients with cerebral palsy
Authors: Ilharreborde Brice , de Saint Etienne Adrien , Presedo Ana , Simon Anne-Laure 
Published: February 2020

Purpose Spinal sagittal alignment restoration has been associated with improved functional outcomes and with reduced complications rates. Several limitations exist for radiological analysis in cerebral palsy (CP) patients. The goal of this study was to summarize the existing literature and report the important considerations to evaluate in a CP patient undergoing spinal surgery. Methods A retrospective radiological analysis was performed, including non-ambulant CP children with progressive scoliosis. Full-spine sitting radiographs performed pre-and postoperatively were required to measure spino-pelvic sagittal parameters. Result A total of 23 non-ambulating CP patients were included, mean age 16.0 years (standard error of the mean 0.5). Two distinct groups of patients were identified. Group 1 (61%) were patients with less trunk control (lumbar lordosis (LL) < 50°), retroverted and vertical pelvis (mean sacral slope (SS) 11.4° and pelvic tilt (PT) 38.1°) and anterior imbalance (mean sagittal vertical axis (SVA) 5.9 cm) and Group 2 (39%) were patients with better trunk control (LL > 60°, anteverted and horizontal pelvis (mean SS 49.3°, PT 9.7°) and posterior imbalance (mean SVA 5.8 cm). Postoperative measures showed significant impact of surgery with a PT reduction of 19° (p = 0.007), a mean SS increase of 15° (p = 0.04) and a LL gained of 10° (p = 0.2). Conclusion Sagittal spino-pelvic alignment in non-ambulating CP patients remains difficult to assess. The current literature is poor but our radiological study was able to define two distinct groups among Gross Motor Function Classification System (GMFCS) level V patients, based on the quality of their trunk control. All possible factors that may influence head and trunk posture should be systematically considered and optimized. Level of evidence Level IV
The simultaneous removal of reactive and disperse dyes by Electrocoagulation Process with a bipolar connection of combined Iron and Aluminum electrodes: Experimental design and Kinetic studies
Authors: Sqalli Noufissa , Essadki Abdelhafid , Elqars Essedik , Elqars Essedik 
Published: February 2020

This study concerns the ability of electrocoagulation process to remove simultaneously disperse and reactive dyes by using combined iron and aluminum electrodes in bipolar mode. A statistical experiment design (Response Surface Methodology: RSM) was adopted to model the process and to optimize the parameters influencing the removal efficiency of the dyes. The mathematical model is established, using a rotatable central composite design uniform to study the empirical relationships between two responses (Removal efficiency, energy consumption) and five factors: initial pH, current density, the concentration of supporting electrolyte, time and stirring speed. This treatment, therefore, led to a removal efficiency that can reach more than 95% with low consumption energy of 9 kWh/Kg of removed dye. Kinetic, isotherm adsorption and thermodynamic studies were undertaken with the optimized parameters. Electrocoagulation mechanism was modeled using adsorption kinetics and isotherm models, it is sited were on the insoluble iron and aluminum flocs. This study shows that the Freundlich model fit the adsorption isotherm, the kinetic of the electrocoagulation is better presented by the pseudo- second-order kinetic, the adsorption is endothermic and spontaneous for both dyes. Analysis of the sludge allowed quantifying the role of each electrode in removing dyes.
Fixed physical length spoof surface plasmon polariton delay lines for a 2-bit phase shifter
Authors: Unutmaz Muhammed Abdullah , Unlu Mehmet 
Published: February 2020

A novel and promising candidate for the main building block of the 2-bit, 360° phase shifters, namely, the fixed physical length, spoof surface plasmon polariton (sSPP) delay lines, is presented. An analytical approach is used for the calculation of the electrical lengths of the sSPP delay lines for what we believe is the first time. The delay lines use the idea of changing the corrugation depths of the sSPP waveguides (WGs), which allows us to obtain different electrical lengths without changing the physical length of the WG. The special design of the coplanar WG to sSPP WG transitions maintains the mode conversion under different phase states and minimizes the insertion and return losses for all phase states. The measurement results of the fabricated delay lines for four different phase states show good agreement with the simulations, having average and maximum phase errors of 1.7% and 3.6% with respect to the ideal phase states, 0.5% and 1.2% with respect to the simulations, and average and maximum insertion losses of

−

0

.

26

and

−

0

.

43

d
B

at 7.15 GHz, respectively. The proposed designs, to the best of our knowledge, are the first instances of the sSPP delay lines for low-loss, high-accuracy, compact phase shifters with real-life design constraints.
Probing optical mode hybridization in an integrated graphene nano-optomechanical system
Authors: Dash Aneesh , Selvaraja S. K. , Naik A. K. 
Published: February 2020

We propose a scheme for sensitive local monitoring of mode hybridization in vertically asymmetric waveguides with a nano-optomechanical probe based on graphene. Extracting local information about mode hybridization is challenging using intensity measurements at the output or scanning optical probes over the waveguide. Transferring the information about the guided field profiles into the mechanical mode of graphene (with ultra-low-force sensitivity) using the optical gradient force allows for sensitive probing of the mode hybridization. In our proposed scheme, we estimate that a 100% change in the TE fraction of the fundamental quasi-TM waveguide mode would cause a change in the vibration amplitude of graphene on the order of 1000 pm. The limit of detection of the TE fraction is approximately 0.001. The change in the TE fraction due to index perturbations in the core and cladding can also be used for index sensing with responsivity on the order of 1000 pm change in vibration amplitude per refractive index unit and a limit of detection of

2
×

10

−
4

refractive index units. This work provides novel methods for applications in optomechanical modulation and sensing.
Gifts of welcome: Precarity, intimacy and the gift in Die Farbe des Ozeans (Peren, 2011) and Welcome (Lioret, 2009)
Authors: Stehle Maria , Weber Beverly 
Published: February 2020

Abstract
This article examines the role of Europe as gift in Lioret's Welcome (2009) and Peren's Die Farbe des Ozeans (2011) by focusing on gestures of welcome extended by white European characters to undocumented migrants. In both films, these gestures include gifts, in the form of money, shelter or skills taught, that play an important narrative role, but subordinate refugee characters' lives and stories to the emotional needs of white European 'givers'. In this way gifts of welcome become violent acts that reinforce European assumptions about European political and epistemological superiority, and paper over the existence of colonial and racist violence that continues to produce precarious lives.
Falling in love with robots: a phenomenological study of experiencing technological alterities
Authors: Viik Tõnu 
Published: February 2020

AbstractIs it possible for human beings to establish romantic relationships with robots? What kind of otherness, or alterity, will be construed in the process of falling in love with a robot? Can a robotic companion mean more than being a tool for house-work, a caretaker, an aid of self-gratification, or a sex-doll? Phenomenological analysis of love experience suggests that romantic feelings necessarily include experiencing the alterity of the partner as an affective subjectivity that freely, willingly, and passionately commits to its partner. The romantic commitment is expected to stem from the sentient inner selves of the lovers, which is one of the features that robots are lacking. Thus the artificial alterity might disengage our romantic aspirations, and, as argued by many, will make them morally inferior to intraspecies love affairs. The current analysis will restrain from ethical considerations, however, and will focus on whether robots can in principle elicit human feelings of love.
Zum Begriff der Sprachbewusstheit in der Schreibforschung und -didaktik
Authors: Akbulut Muhammed , Schmölzer-Eibinger Sabine , Ebner Christopher 
Published: February 2020

AbstractThe goal of text-procedure-oriented writing instruction models is to foster metalinguistic awareness, but they lack a sound theoretical foundation for the concept of metalinguistic awareness. In response to this, this paper discusses theories from the field of metalinguistic awareness research, which are then used to develop a text-procedure-orientated writing instruction model. Using a mixed methods approach which combines inferential statistics, corpus analysis and the in-depth analysis of individual cases, the writing instruction model was evaluated, and the texts produced by the students were analyzed in conjunction with their collaborative writing dialogues (since these document the genesis of the texts) to examine the relationship between metalinguistic awareness and academic writing competence.
Bewertungen sprachlichen Handelns und good practice in der Angewandten Gesprächsforschung
Authors: Brünner Gisela , Pick Ina 
Published: February 2020

AbstractThe article focuses on methodological issues of practice-oriented discourse research and suggests several methodological approaches to assess conversational practice. It makes an argument for the relevance of assessing conversational practice and for why aspects of good practice should be included more systematically in the analyses by way of considering objectives in the examined practice domains. We provide examples of different institutional fields (mostly doctor-patient and lawyer-client interaction) and discuss how actual communicative practices can be assessed with methods of discourse analysis. We thus aim to expand the methodological spectrum of conversation research by including matters of immediate social interest and aspects that are relevant for practitioners.
Positionierungen in argumentativen Gesprächen und Briefen der Schule
Authors: Grundler Elke , Rezat Sara , Schmölzer-Eibinger Sabine 
Published: February 2020

Abstract
The current research in the field of argumentation in school contexts predominantly focuses on the development of oral and written argumentation skills and interventions to improve students’ argumentative skills, while comparative studies of argumentative practices in different modes, particularly the linguistic features of oral versus written argumentative practices, are still rare. To close this gap, our study investigates argumentative oral and written practices of students in secondary school to answer the question whether the mode has an influence on the use of specific procedures and linguistic features. We examined how students express their stance on a controversial issue linguistically (Positionierung) by analyzing a small corpus of argumentative discussions and letters by 12th grade students. The results of the study show that while students use similar procedures and linguistic features in both modes, they are more varied and multifaceted in discussions, i. e. oral communication, than in letters, i. e. written communication.
Sprachnormbezogene Akkommodation in der Hochschullehre
Authors: Vergeiner Philip C. 
Published: February 2020

AbstractThis paper examines the relationship between accommodation processes and social norms in varietal choice within tertiary education in Austria. The investigation consists of (a) a content analysis of metalinguistic statements in semi-structured interviews and (b) a variable rule analysis of actual language variation in university lectures.The findings show that there are norms prescribing that listeners must have at least be able to comprehend a particular variety, whereas accommodation to actual language use does not appear to be required to the same extent. However, the norms depend strongly on group membership: while there is a norm prescribing the use of the standard variety in the presence of speakers of German as a foreign language, there is no such norm for Austrians vis-à-vis people from Germany, although speakers from both groups may lack the ability to understand the respective nonstandard varieties. This difference can be explained by the sociocultural context and differing language attitudes.
BlobToolKit – Interactive Quality Assessment of Genome Assemblies
Authors: Challis Richard , Richards Edward , Rajan Jeena , Cochrane Guy , Blaxter Mark 
Published: February 2020

AbstractReconstruction of target genomes from sequence data produced by instruments that are agnostic as to the species-of-origin may be confounded by contaminant DNA. Whether introduced during sample processing or through co-extraction alongside the target DNA, if insufficient care is taken during the assembly process, the final assembled genome may be a mixture of data from several species. Such assemblies can confound sequence-based biological inference and, when deposited in public databases, may be included in downstream analyses by users unaware of underlying problems. We present BlobToolKit, a software suite to aid researchers in identifying and isolating non-target data in draft and publicly available genome assemblies. BlobToolKit can be used to process assembly, read and analysis files for fully reproducible interactive exploration in the browser-based Viewer. BlobToolKit can be used during assembly to filter non-target DNA, helping researchers produce assemblies with high biological credibility. We have been running an automated BlobToolKit pipeline on eukaryotic assemblies publicly available in the International Nucleotide Sequence Data Collaboration and are making the results available through a public instance of the Viewer at https://blobtoolkit.genomehubs.org/view. We aim to complete analysis of all publicly available genomes and then maintain currency with the flow of new genomes. We have worked to embed these views into the presentation of genome assemblies at the European Nucleotide Archive, providing an indication of assembly quality alongside the public record with links out to allow full exploration in the Viewer.
The Temporal Dynamics of Background Selection in Nonequilibrium Populations
Authors: Torres Raul , Stetter Markus G , Hernandez Ryan D , Ross-Ibarra Jeffrey 
Published: February 2020

Abstract
Neutral genetic diversity across the genome is determined by the complex interplay of mutation, demographic history, and natural selection. While the direct action of natural selection is limited to functional loci across the genome, its impact can have effects on nearby neutral loci due to genetic linkage. These effects of selection at linked sites, referred to as genetic hitchhiking and background selection (BGS), are pervasive across natural populations. However, only recently has there been a focus on the joint consequences of demography and selection at linked sites, and some empirical studies have come to apparently contradictory conclusions as to their combined effects. To understand the relationship between demography and selection at linked sites, we conducted an extensive forward simulation study of BGS under a range of demographic models. We found that the relative levels of diversity in BGS and neutral regions vary over time and that the initial dynamics after a population size change are often in the opposite direction of the long-term expected trajectory. Our detailed observations of the temporal dynamics of neutral diversity in the context of selection at linked sites in nonequilibrium populations provide new intuition about why patterns of diversity under BGS vary through time in natural populations and help reconcile previously contradictory observations. Most notably, our results highlight that classical models of BGS are poorly suited for predicting diversity in nonequilibrium populations.
Ad-hoc-Publizitätspflicht einer Muttergesellschaft bei konzerndimensionalen Sachverhalten
Authors: Kumpan Christoph , Misterek Robin 
Published: February 2020

Zusammenfassung
Das Bekanntwerden von Manipulationen bei Dieselfahrzeugen durch Volkswagen hat nicht nur den Absatzmarkt für Automobile, sondern auch den Kapitalmarkt erschüttert. Mehrere Gerichte beschäftigen sich seither mit der Frage, ob das Anlegerpublikum früher über die Rechtsverstöße und Ermittlungen hätte unterrichtet werden müssen. Das LG Stuttgart hatte dabei zu klären, ob auch die Dachgesellschaft von VW – die Porsche SE – zur Abgabe einer Ad-hoc-Meldung verpflichtet war. Wann eine börsennotierte Muttergesellschaft in der Sphäre einer konzernangehörigen Tochtergesellschaft entstandene Insiderinformationen veröffentlichen muss, war bisher in der Rechtswissenschaft hoch umstritten. Das Gericht hatte deshalb die Möglichkeit, über den Einzelfall hinaus Maßstäbe für die Publizitätspraxis von Konzernen zu setzen und Rechtssicherheit zu schaffen.
Preliminary Speech Rate Normative Data in Adult Jordanian Speakers
Authors: Damhoureyeh Mohammad A. , Darawsheh Wesam B. , Qa’dan Wa’el N. , Natour Yaser S. 
Published: February 2020

Studies conducted to establish normative data on speech rate; including speaking and articulation rate, for the Jordanian Arabic dialect are scarce. Aim: to establish preliminary normative data on speaking and articulation rate for the adult male and female Jordanian Arabic speakers. Methodology: The sample of the study comprised 51 participants (23 males and 28 females), age (18-25 yrs, mean 20.82 yrs ±1.52). Spontaneous speech and reading samples were collected from participants. Results: Means of articulation rates during the tasks of spontaneous speech and reading passage were (140.07 w/m, 161.83 w/m, respectively), while the means of speaking rates during the tasks of spontaneous speech and reading passage were (124.51w/m, 141.36w/m, respectively). The ANOVA showed no significant differences (p=0.237) attributed to the effect gender on the articulation or the speaking rates in both tasks of spontaneous speech and reading passage. Pearson-r test showed moderate-strong positive correlations between articulation and speaking rates during both the reading passage and the spontaneous speech tasks (p<0.01, r = 0.416; p <0.001, r = 0.962, respectively). Conclusion: this study can be of a clinical significance in the evaluation and treatment of fluency, articulation and motor speech disorders.