bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Imaging characteristics of primary hepatic sarcomatoid carcinoma and sarcoma: a comparative study
Authors: Shi Dongli , Li Hongjun , Sun Jun , Ma Liang , Chang Jing 
Published: April 2020

Abstract
Background
Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS) are rare malignancy with frequent overlap in the clinic and radiology. There has never been a comparative study of these tumors for the restricted cases. The purpose of our study was to analyze the clinical and imaging features of PHSCs and PHSs, with an emphasis on the particularities and similarities by comparing the two tumors.
Methods
We retrospectively analyzed the clinical and imaging features of 39 patients with pathologically proven PHSCs (n = 23) and PHSs (n = 16) from three university centres over a 9-year period from 2010–2019. Univariate analyses were performed to determine the consistent and distinctive features.
Results
The background of chronic hepatitis or cirrhosis was observed with a high frequency in both of PHSCs (73.7%) and PHSs (62.5%). Tumors with a diameter more than 10 cm were significantly more common in PHSs than PHSCs (p = 0.043) and cystic masses were more detected in PHSs (P = 0.041). Both of PHSCs and PHSs mainly present hypovascularity (73.7% vs 82.6%). The ring hyper enhancement on the arterial phase (AP) and wash out were more frequently seen in PHSCs and the iso-hypo enhancement on the AP followed persistent or progressive enhancement were more commonly detected in PHSs (all, p < 0.05).
Conclusion
PHSC and PHS generally present as mass lesions with hypovascularity. The ring hyper enhancement on the AP and wash out favor the diagnosis of PHSC. The large size greater than 10 cm, cystic lesion, iso-hypo persistent or progressive enhancement pattern might suggest the possibility of PHSs.
Observing inter-professional videos: impact of collaboration between physicians and psychologists on attitude and knowledge acquisition
Authors: Großer Johannes , Kimmerle Joachim , Shiozawa Thomas , Hirt Bernhard , Bientzle Martina 
Published: April 2020

Abstract
BackgroundInter-professional collaboration (IPC) is an important prerequisite for successful patient care. Even though inter-professional education (IPE) is increasingly common in undergraduate medical education, few IPE approaches explicitly address the IPC among medical students and students of psychology. IPE videos can be used to give learners the opportunity to gather relevant knowledge from different professional perspectives. So far it has been unclear whether it is enough when the topic of the video itself is inter-professional or if it is necessary for experts from different professions explicitly to appear in the video.MethodsIn an online experiment, medical students watched one of two videos about Parkinson’s disease (PD) and the care of PD patients. The information was either provided by protagonists from only one profession (i.e., physicians; mono-professional condition) or provided by protagonists from two different professions (i.e., physicians and a psychologist; inter-professional condition). Attitude toward inter-professional interaction and learning, evaluation of the entertaining and illustrative character of the video, attitude toward physicians and psychologists, importance of IPC, evaluation of psychological treatment support, and knowledge acquisition served as dependent variables.ResultsThe analysis was based on 140 participants (74 in the mono-, 66 in the inter-professional condition). We found that the inter-professional video was perceived to be more entertaining than the mono-professional video (t(138) = -2.227; p = 0.028; d= 0.38). The inter-professional video was also considered to be more illustrative (t(138) = -6.269; p < 0.001; d= 1.06). Moreover, participants improved their attitude toward physicians by watching the video (F(1, 138) = 4.860, p < 0.001, η2p = 0.11), but they did not change their attitude toward psychologists (p = 0.146). Participants who watched the inter-professional video considered IPC to be more important than participants who watched the mono-professional video (t(138) = -7.954; p < 0.001; d= 1.354). Finally, the inter-professional video led to better performance in the knowledge test (t(138) = -2.285; p = 0.024; d= 0.04).ConclusionsInter-professional videos showing explicitly the appearance of experts from different professions come along with several advantages. We discuss the implications of their application in educational practice.Trial registrationThe study was pre-registered on the pre-registration platform AsPredicted (aspredicted.org) before we began data collection (registration number: #33143).
Prevalence and factors associated with Trichomonas vaginalis infection among men who have sex with men and female sex workers in Togo, 2017.
Authors: TCHANKONI Martin Kouame , SADIO Arnold Junior , GBEASOR-KOMLANVI Fifonsi Adjidossi , FERRÉ Valentine Marie , ZIDA-COMPAORE Wendpouiré Ida Carine , DORKENOO Ameyo Monique , SAKA Bayaki , DAGNRA Anoumou Claver , CHARPENTIER Charlotte , Ekouevi Didier Koumavi 
Published: April 2020

Abstract
Background
The aim of this study was to estimate the prevalence and factors associated with Trichomonas vaginalis (T. vaginalis) among men who have sex with men (MSM) and female sex workers (FSW) in Togo in 2017. A cross-sectional bio-behavioral study was conducted from August to October 2017 using a respondent-driven sampling method in four cities in Togo.
Methods
A standardized questionnaire was used to record socio-demographic data and sexual behavior patterns. T. vaginalis detection by molecular biology tests was performed using Allplex STI Essential Assay which detect also 6 others micro-organisms. A blood sample was drawn and serological test using SD Bioline Duo VIH/Syphilis rapid test was performed for HIV and syphilis testing.
Results
A total of 517 key populations including 310 FSW and 207 MSM with median age 24 years, interquartile range (IQR) [20–28 years] were included. The overall prevalence of T. vaginalis, HIV, Mycoplasma genitalium, Chlamydia trachomatis (C. trachomatis), Neisseria gonorrhoeae were 3.9%, 16.8%, 9.3%, 7.5% and 7.2% respectively. T. vaginalis prevalence among FSW was 6.5% (95%CI= [4.1–9.9]) and 0.0% (95%CI= [0.0-2.3]) among MSM. Logistic regression was conducted to identify factors associated with T. vaginalis infection. Living in Lomé (AOR = 3.19; 95%CI= [1.11–11.49]), having had sexual intercourse before the age of 18 (AOR = 5.72; 95%CI= [1.13–10.89]), and being infected with C. trachomatis (AOR = 3.74; 95%CI= [2.95–12.25]) were factors associated with T. vaginalis among FSW.
Conclusion
The prevalence of T. vaginalis infection using molecular test was low among MSM and FSW in Togo. Extensive studies are needed to confirm and better understand the epidemiology of T. vaginalis in these populations and in other populations in Togo.
Identification of risk factors for hyperamylasemia during laparoscopy-assisted surgery for colorectal cancer: a retrospective cohort study
Authors: Zhang Jizhun , Wang Chunjian , Peng Lipan , Xu Tao , Zuo Jiyang , Zhuo Hongqing , Li Leping , Du Fengying 
Published: April 2020

Abstract
Background: Many complications are frequently reported in the carbon dioxide pneumoperitoneum surgery, except hyperamylasemia occurring in pancreas.Methods: Using data from 380 patients with colorectal cancer registered for a prospective cohort study comparing postoperative serum amylase level, risk factors for postoperative hyperamylasemia and surgical complications were identified by multivariate logistic regression analysis.Results: Hyperamylasemia occurred in 140 patients, and a total of 52 patients in 380 patients had short-term postoperative complications, including 25 patients with hyperamylasemia in which 2 patients with acute pancreatitis. The method of operation, injury of pancreas during operation, the duration of pneumoperitoneum and intraoperative blood loss were significant predictors of hyperamylasemia. However, the economic significance of this phenomenon is not certain.Conclusion: High incidence of hyperamylasemia in laparoscopy-assisted surgery for colorectal cancer, the incidence of postoperative infectious complications will increase significantly. Surgical treatment of rectal cancer, operation around the pancreas, intraoperative blood loss, duration of pneumoperitoneum should be considered when planning surgery. Although patient’s hospital cost and postoperative hospital stay were well documented, it is unclear whether this is of any economic significance.Trial registration: The study was registered with the China Clinical Trial Registry with registration number ChiCTR1800015311 and was registered on March 22, 2018.
Early CT imaging markers of COVID-19 progression
Authors: Chen Yanqing , Tang Ningning , Fu Zhao , Wei Youyong , Ma Longbai , Lu Yumin , Ye kun , Liao Xin , Su Yuandong , Huang Guangyi , Yuan Jun , Wu Qiuxia , Xu Fan , Yang Yingxia 
Published: April 2020

Abstract
Background: Early recognition of patients who are prone to develop severe or critical COVID-19 pneumonia may improve its management and modify its outcome by better treatment regimens.Objective: To investigate Computed Tomography (CT)-based early markers of COVID-19 progression. Material and methods: Thirty-two COVID-19 patients were retrospectively enrolled, including 23 moderate cases who remained moderate until being cured and discharged from hospital, and 9 progressive cases who started with moderate pneumonia and later progressed to severe or critical pneumonia. Clinical and CT data in the early course of disease were reviewed and compared. The association between early features and progression of COVID-19 were analyzed. Results: The multivariate logistic regression analysis revealed that the progression of COVID-19 were significantly associated with older age and higher CT score of the right lower lobe in the early CT images. After adjustment for relevant covariates, the relationship between CT score of the right lower lobe and COVID-19 progression persisted (odds ratio 19.28, 95% confidence interval 1.07 - 348.34).Conclusions: Higher CT Score of the right lower lobe in early images and older age appeared to be promising biomarkers for early prediction of COVID-19 prognosis. Extensive involvement of the right lower lobe at the early stage may suggest a high risk of progression.
The prognostic value of gender in gastric gastrointestinal stromal tumors: A propensity score matching analysis.
Authors: Rong Jian fang , Chen Si hai , Song Cong hua , Wang Huan , Zhao Qiao yun , Zhao Ru lin , He Ya jing , Yan Li li , Song Yan ping , Wang Fang fei , Xie Yong 
Published: April 2020

Abstract
Background
Gastrointestinal stromal tumors (GISTs) of the stomach are the most common GISTs. The risk, incidence and outcome of cancer are different between the sexes. Whether gender is related to the prognosis of gastric stromal tumors is unclear. Therefore, this study aims to explore the relationship between gender and gastric GIST prognosis.
Methods
Data from gastric GIST patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database. After propensity score matching (PSM) was performed to reduce confounding factors, the clinicopathological features and prognosis of GIST patients were comprehensively evaluated.
Results
There were 512 male patients and 538 female patients with gastric GIST. The gender of gastric GIST patients was associated with marital status, surgical treatment, tumor size, and mitotic index (P < 0.05). The Kaplan-Meier analysis and log-rank test revealed that male patients had a higher mortality rate than female patients (P = 0.0024). After matching all the potential confounding factors, the survival of the female gastric GIST patients was better than that of the male gastric GIST patients (P = 0.042). Cox regression analysis revealed that gender was an independent risk factor for overall survival. The risk of death was higher for males than for females (HR: 1.539, 95% CI: 1.066–2.222, P = 0.021).
Conclusion
Gender could be a prognostic factor for gastric GIST survival, and male patients had a higher risk of death.
Clouds over IEMs? Perspectives for Inborn Errors of Metabolism in adults from a retrospective cohort studies in two Swiss adult metabolic Clinics
Authors: Gariani Karim , Nascimento Marnia , Superti-Furga Andrea , Tran Christel 
Published: April 2020

Abstract
Background: Inborn errors of metabolism (IEMs) are complex medical conditions. Thanks to improvements in diagnostics and treatment, a growing number of pediatric IEM patients reach adulthood. Thus, clinical care for adults with IEM has become an emerging and challenging reality. This purpose of this study of adults with IEM in an adult metabolic clinic at two academic hospitals (Lausanne and Geneva) was to help make informed decisions on the future organization of health care for this group of patients. Methods: All adult patients with a biochemical and/or genetic diagnosis of IEM followed at the Clinic were included in the study. Electronic patient records were reviewed for clinical features, diagnostic studies, treatment and long-term outcome. Data of undiagnosed patients referred for IEM suspicion were analyzed separately.Results: 126 patients were included in the study. The most prevalent group of diseases was small molecules disorders with 83 (66%) patients, followed by energy defects disorders with 28 (22%) patients and complex molecules disorders with 15 (12%) patients. Overall, 64% of patients were diagnosed before, and 37 % after the age 16 years. Among the 126 IEM, 51% suffered from medical complications. 79% of the patients were receiving a specific treatment for their disease. Among the 140 undiagnosed patients referred for suspicion of IEM, investigations lead to a diagnosis in 29 (21%) patients. 24 had confirmation of an IEM and 5 were found to have another genetic condition.Conclusions. This retrospective study reveals significant features of adult IEM cohort. The disorders are heterogeneous, and there is no one-size-fits-all approach – treatment must be tailored to fit each specific disorder in each individual patient. Even patients who are followed tightly are not protected from metabolic decompensations and/or chronic organ-specific complications. While it is commonly assumed that patients with IEMs are more stable once they become adults, our data show that the diseases continue to exact a lifelong toll. A coordinated monitoring of target organs by a multidisciplinary team is needed. To ensure that the success in diagnosis and treatment of individuals with IEMs is sustained, there is a clear requirement for adequately staffed adult IEM clinics.
Comparison Of Human Articular Cartilage Tissue And Chondrocytes Isolated From Peripheral vs Central Regions Of Traumatic Lesions
Authors: Acevedo Lina , Iselin Lukas , Berkelaar Majoska , Salzmann Gian , Wolf Francine , Feliciano Sandra , Vogel Nicole , Pagenstert Geert , Martin Ivan , Pelttari Karoliina , Barbero Andrea , Arnold Markus P. 
Published: April 2020

Abstract
Background. It is generally assumed that traumatic cartilage lesions affect the whole joint homeostasis. However, it remains unknown to which extent the properties of chondrocytes within lesions are affected compared to cells from adjacent locations. To unravel cellular and molecular events occurring in cartilage regions close to injury sites, we collected cartilage biopsies from the central part of the lesions ( central ) and from regions closely surrounding the lesion ( peripheral , 2-5mm distance from defect) of traumatic joints and assessed their key functional properties. Additionally, we investigated the correlation of these properties with the inflammatory features of the joint and the quality of the initial cartilage biopsy. Methods. Cartilage samples were collected from the knee joints of 42 patients (male:female = 7:3, age range: 18-60y) with traumatic knee injuries and analysed for cell phenotype (by RT-PCR), histological quality (using a grading score based on glycosaminoglycan staining), cellularity (cell numbers/gram tissue, isolated after enzymatic digestion), cell viability, proliferation capacity (cell doublings/day) and post-expansion chondrogenic capacity of chondrocytes (Bern score of chondrogenically cultured cells in pellets). In addition, synovial tissues were harvested and analysed for the expression of inflammatory cytokine genes. Results. Cartilage quality and post-expansion chondrogenic capacity were higher in peripheral vs central samples. Differences between these two parameters were more pronounced in joints with high (vs low) inflammatory features, as characterised by >100-fold difference in the mRNA levels of IL-6 and IL-8 in the corresponding synovial tissues. Peripheral chondrocytes isolated from initially good compared to bad quality biopsies expressed higher levels of chondrogenic markers (type II/I collagen and aggrecan/versican ratios) and lower levels of cartilage degrading markers MMP13 and ADAMTS5. They also exhibited reduced proliferation and enhanced cartilage-forming capacity. Conclusions. Chondrocytes at the periphery of traumatic lesions better maintain properties typical of healthy cartilage as compared to those isolated from central parts even when derived from bad quality tissues harvested from highly inflamed joints. Future studies will be necessary to investigate the change of functional properties of peripheral chondrocytes over time and, consequently, to identify a “point of no return” (since onset of symptoms) for a possible use of such chondrocytes in cartilage repair strategies.
High triglyceride-glucose index is associated with adverse cardiovascular outcomes in patients with acute myocardial infarction
Authors: Zhang Yue , Ding Xiaosong , Hua Bing , Liu Qingbo , Gao Hui , Chen Hui , Zhao Xue-Qiao , Li Weiping , Li Hongwei 
Published: April 2020

Abstract
Background
Triglyceride glucose (TyG) index is considered a new marker for metabolic disorders. Although recent studies have found an association between TyG index level and vascular disease development, the prognostic value of TyG index in patients with acute myocardial infarction (AMI) remains unclear.
Methods
A total of 3181 patients with AMI, who underwent coronary angiography, were identified from the Cardiovascular Center of Beijing Friendship Hospital Database Bank and included in the analysis. Patients were stratified into 2 groups according to their baseline TyG index levels: the TyG index < 8.88 group and the TyG index ≥ 8.88 group. Clinical characteristics,biochemical parameters, and the incidence of major adverse cardiovascular events (MACEs) during a median of 33.3-month follow-up were recorded. The TyG index was calculated using the following formula: ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2].
Results
Kaplan-Meier analysis revealed no significant difference in the incidence of all-cause death and cardiac death between the 2 groups. Compared with the TyG index < 8.88 group, the TyG index ≥ 8.88 group had significantly higher incidences of non-fatal MI, revascularization, cardiac rehospitalization and composite MACEs. Multivariable Cox regression models revealed that the TyG index was positively associated with all-cause death [HR (95% CI): 1.51 (1.10,2.06), P = 0.010], cardiac death [HR (95%CI): 1.68 (1.19,2.38), P = 0.004], revascularization [HR (95%CI): 1.50 (1.16,1.94), P = 0.002], cardiac rehospitalization [HR (95%CI): 1.25 (1.05,1.49), P = 0.012], and composite MACEs [HR (95%CI): 1.19 (1.01,1.41), P = 0.046] in patients with AMI. The independent predictive effect of TyG index on all-cause death and cardiac death was mainly reflected in the subgroups of male gender, body mass index ≥ 25 kg/m2, smoker, diabetes mellitus, estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m2, high-density lipoprotein cholesterol ≥ 1.01 mmol/L and left ventricular ejection fraction (LVEF) ≥ 0.50. The results also revealed that diabetes mellitus, previous AMI, eGFR, LVEF, and multi-vessel/left main coronary artery lesions were independent predictors of MACEs in patients with AMI (all P < 0.05).
Conclusions
High TyG index levels appeared to be associated with an increased risk of MACEs in patients with AMI. The TyG index might be a valid predictor of cardiovascular outcomes of patients with AMI.
Trial registration:
retrospectively registered
Women empowerment for abortion and family planning decision making among marginalised women in Nepal: a mixed method study
Authors: KC Heera , Shrestha Mangala , Pokharel Nirmala , Niraula Surya Raj , Pyakurel Prajjwal , Parajuli Surya Bahadur 
Published: April 2020

Abstract
Background
Women empowerment is multidimensional. Women’s education, employment, income, reproductive healthcare decision making, household level decision making and social status are vital for women empowerment. Nepal is committed to achieving women empowerment and gender equality, which directly affects the reproductive health issues. This can only be achieved by addressing the issues of the poor and marginalised communities. In this context, we aimed to find the association of women empowerment with abortion and family planning decision making among marginalised women in Nepal.
Methods
A mixed-method study was conducted at selected municipalities of Morang district of Nepal from February 2017 to March 2018. Cross sectional study was conducted among 316 married marginalised women of reproductive age (15–49 years) and key informants interview was conducted among 15 representative healthcare providers and local leaders. From key informants, data were analysed using the thematic framework method. Findings obtained from two separate analyses were drawn together and meta inferences were made.
Results
Women empowered above average were 50.6%. Current use of modern contraceptives were more among below average empowerment groups (p 0.041, OR 0.593 C.I. 0.36–0.98). We could not find any statistical significant differences among women empowerment with abortion knowledge (p 0.549); family planning knowledge (p 0.495) and women’s’ decision for future use of modern contraceptives (p 0.977). Most of key informants reported that unsafe abortion was into practice.
Conclusions
Women empowerment has no direct role for family planning and abortion decision making at marginalised communities of Morang district of Nepal. There was direct influence of different organisations for seeking healthcare services on abortion and family planning despite having women empowerment.