bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migrating Dental Implants Into the Maxillary Sinus; Evaluation of Different Direct Trans-Oral Surgical Approaches
Authors: Hamdoon Zaid , Mahmood Nazhat , Talat Wael , Sattar Abier Abdul , Naeim Karrar , Qais Ahmed , Kheder Waad , Jerjes Waseem 
Published: August 2020

Abstract
Background: Dental implant surgery in atrophied maxilla has many risks, in some patients simultaneous sinus lifting with implant placement must be performed to increase the chances of successful implant which can cause implant migration. The aim of this study was to illustrate different surgical approaches to remove displaced dental implants into the maxillary sinus. Methods: Eleven patients were diagnosed with implant migration into the maxillary sinus. Radiographs were taken to identify the exact location of these implants which showed that they can be displaced in four anatomical area: sinus floor above the alveolar bone, near the junction of the sinus and nasal floor, near the floor of the orbit, and the most posterior aspect the sinus. The surgical removal was performed through four different trans-oral approaches depending on the location of the displaced implant. The surgical challenges, duration of surgery and postoperative complications were reported.Results: The least challenging surgical intervention was noted when removing the displaced implants from the floor of the sinus. More challenges were experienced during the surgical removal of anteriorly displaced implants near the nasal cavity using the Caldwell-Luc technique (anterior window) with noted difficulty to differentiate between the nasal cavity and maxillary sinus. Implant displacement into the maxillary sinus roof near the orbital floor can be technically challenging due to surgical access and the proximity of vital anatomical structures. Bleeding from the pterygoid venous plexus was profound with posterior lateral approach. Discussion: The choice of the appropriate surgical approach to retrieve displaced dental implants into the maxillary sinus depends on the implant’s location and the surrounding vital anatomical structures.
Multiple Isolated Extramedullary Relapse and Long-term Survival of One AML Patient
Authors: Li Jiman , Liu Yang , Li Yunzhu , weiping liu 
Published: August 2020

Abstract
Background: Granulocytic sarcomas (GS) are very rare. If it occurs after complete remission of acute myeloblastic leukemia（AML）, it indicates a recurrence of AML and a poor prognosis. In such cases, relapse of leukemia occurs within a mean of 10 months following granulocytic sarcoma.Case presentation: Here we present an unusual case of 78-year-old male who presented with AML-M1 38 years ago. After complete remission from AML-M1 6 years later, he developed unusual multiple isolated extramedullary relapses. And the extramedullary relapse occurred 7 times and involved 8 anatomic sites during 15 years. Despite repeated relapses, treatment and physical damage, the patient managed to survive into 2016.However, we did not detect any signs of leukemia after 1992 and his bone marrow and peripheral blood remained normal Until his death. Immunohistochemical results of our case are all the same, suggesting that they were all derived from the recurrence of the same tumor.Conclusions: Extramedullary relapses may occur in AML patients after complete relieve and without the blood count and BM involvement. Accurate diagnosis of GS is important so the patient could to be treated timely. It is a challenge for the pathologist to make the diagnosis, and without immunohistochemistry (IHC), it may be misdiagnosed as another tumor.
The potential effect of the angiotensin-converting enzyme 2 (ACE2) receptor of 2019-nCoV on lung adenocarcinoma patients
Authors: huo qin , li zhenwei , shao ling , chen siqi , li jiaying , xie ni 
Published: August 2020

Abstract
BackgroundThe 2019-nCoV epidemic is the public health emergency that has had the greatest impact on the world. Our study aimed to better understand the underlying mechanisms and function of angiotensin-converting enzyme 2 (ACE2) receptor of 2019-nCoV on lung adenocarcinoma patients (LUAD), and provide a theoretical basis for early diagnosis, prognosis and targeted therapy of 2019-nCoV. MethodsThis study focuses on the expression level, functions, mutation rate, and copy number variations (CNVs) of ACE2 in LUAD using an extensive bioinformatics data mining process. The interaction between ACE2 expression and clinical-pathological parameters of patients with LUAD was investigated using UALCAN. Also, the essential biological features, single nucleotide variations (SNVs), CNVs, and pathway activities of genes interacting with ACE2 in these cancers were further analyzed. ResultsWe found that ACE2 expression in LUAD patients increased with age, but it was not related to cancer status, patient’s race, patient’s gender, or patient’s smoking habits. Moreover, our results showed that compared to that in normal tissues, ACE2 was highly expressed in colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), and stomach adenocarcinoma (STAD). However, there is no significant difference in the expression of ACE2 in patients of different ages. ConclusionsThese findings demonstrate the importance of ACE2 in LUAD, and provide insights into the regulatory mechanisms and function of ACE2.
Health-related quality of life of middle-aged and elderly people with hypertension: a cross-sectional survey from a rural area in China
Authors: Chen Qi , Ran Li , Tan Xiaodong 
Published: August 2020

Abstract
Background
The purpose of this study was to evaluate health-related quality of life (HRQoL) of middle-aged and elderly people with hypertension in Enshi, China, and to explore the important correlates defining HRQoL.
Methods
During the period of April through July 2018, a self-monitoring intervention program for hypertension control was implemented in a remote area of central China. Participants completed a cross-sectional survey which included demographic characteristics, the Health-related Quality of Life Survey, and the Pittsburgh Sleep Quality Index Survey. Univariate analysis was performed by analysis of variance, and multiple linear regression analysis was used to analyze the influencing factors of HRQoL in middle-aged and elderly hypertensive patients. In the multivariate analysis, the variables with P ≤ 0.05 in the single factor analysis were combined with the professional significance to establish a multiple linear regression model.
Results
Information from 500 participants was available for analysis. Among them, the scores of PCS and MCS was 31.66 ± 9.50 and 41.38 ± 10.69, respectively. Multivariable regression analyses showed that the influencing factors for PCS scores were age, education level, sleep quality status, tea-drinking habit, and exercise frequency. The influencing factors for MCS scores were family monthly income, sleep quality status, tea-drinking habit, and exercise frequency.
Conclusion
The overall HRQoL for rural middle-aged and elderly hypertensive patients in Xuan’en county of Hubei province was poor. Effective relevant measures for the above factors were urgently needed to improve the quality of life for the elderly in rural areas. Awareness of these relevant factors could help health care professionals provide better supportive care.
Development and clinical validation of A Novel 9-gene prognostic biomarkers based on multi-omics in pancreatic adenocarcinoma
Authors: Xu Dafeng , Wang Yu , Liu Xiangmei , Zhou Kailun , Wu Jincai , Chen Jiacheng , Chen Cheng , Chen Liang , Zheng Jinfang 
Published: August 2020

Abstract
Background: The prognosis of patients with pancreatic cancer remains poor due to the lack of biomarkers for early diagnosis and effective prognosis. Methods: RNA-Seq, SNP, CNV data were downloaded from The Cancer Genome Atlas(TCGA); Univariant cox regression was used to identify prognosis-related genes; GISTIC 2.0 was used to identify significantly amplified or deleted genes; Lasso method was used to construct risk prognosis model, which was then validated in GEO and ICGC cohorts. rms package was used to evaluate the overall predictive performance of the model by calculating and comparing the C-index values with other models. Experiments of western blot were performed to evaluate the expression of genes. Results: 54 candidate genes were obtained after integrating the genomic mutated genes and prognosis-related genes. The Lasso method was conducted to finally ascertain nine characteristic genes, including UNC13B, TSPYL4, MICAL1, KLHDC7B, KLHL32, AIM1, ARHGAP18, DCBLD1, and CACNA2D4. The 9-gene signature model can help with stratifying samples at risk in the training cohort and external validation cohort. In addition, the overall predictive performance of our model is superior to the others. We found that AIM1 and DCBLD1 were highly expressed in tumor tissues, while ARHGAP18, CACNA2D4, and TSPYL4 were lowly expressed in tumor tissues at the protein and transcription levels. Conclusion: The nine-gene signatures constructed in this study can be used as the novel prognostic markers to predict the survival of PAAD patients.
Reporting of Screening and Diagnostic AI Rarely Acknowledges Ethical, Legal and Social Implications: A Mass Media Frame Analysis
Authors: Frost Emma Kellie , Carter Stacy M 
Published: August 2020

Abstract
Introduction. Healthcare is a rapidly expanding area of application for Artificial Intelligence (AI). Although there is considerable excitement about its potential, there are also substantial concerns about the negative impacts of these technologies. Since screening and diagnostic AI tools now have the potential to fundamentally change the healthcare landscape, it is important to understand how these tools are being represented to the public via the media. Methods. Using a framing theory approach, we analysed how screening and diagnostic AI was represented in the media and the frequency with which media articles addressed the benefits and the ethical, legal, and social implications (ELSIs) of screening and diagnostic AI. Results. All the media articles coded (n = 136) fit into one of three frames: social progress (n = 132), economic development (n = 59), and alternative perspectives (n = 9). The vast majority of the articles were positively framed, with 135 of the articles discussing benefits of screening and diagnostic AI, and only 9 articles discussing the ethical, legal, and social implications. Conclusions. We found that media reporting of screening and diagnostic AI was overwhelmingly positive. Screening and diagnostic AI may be represented more positively in the mass media than AI in general. This represents an opportunity for health journalists to provide publics with deeper analysis of the ethical, legal and social implications of screening and diagnostic AI, and to do so now before these technologies become firmly embedded in everyday healthcare delivery.
Analysis of Stress, Strain, and Fatigue Strength of the Rotary Table of Boom-type Roadheaders
Authors: Tian Jie , zhang lansheng , yao haifeng , Wu miao 
Published: August 2020

Abstract
The rotary table is the key component in the optimal design of roadheaders. In this study, a simulation model of the cutting part and a rotary table is established in SolidWorks, and stress analysis and strength evaluation of the structure of the rotary table are performed. To this end, finite element analysis is performed on the basis of the dynamic theory of a coupled multibody system comprising rigid and flexible bodies. Considering actual working conditions, the load file of the cutting head is calculated based on the development of the “Roadheader Machine load Calculation Program”, and the stress and strain cloud map of the cutting head running to the bottom left, middle end, and right end of the rotary table is obtained through Adams simulation. Then, the 6-order modal analysis is carried out, and the S-N curve of the turntable is finally established. In addition, the fatigue life reliability of the turntable is analyzed using the AWE fatigue module. The results show that, provided reliable working conditions, the EBZ160 type roadheader machine during the normal service life shows no risk of fatigue failure under normal working load.
Cardiac Troponin I Associated with Poor Prognosis and Death Risk in 726 Severe and Critical COVID-19 Patients: A Retrospective Cohort Study
Authors: Chen Huilong , Li Xinjie , Marmar Tuohutaerbieke , Xu Qiang , Tu Jing , Li Tong , Han Jun , Xu Dong , Shen Tao 
Published: August 2020

Abstract
Background: A few patients with coronavirus disease 2019 (COVID-19) may progress into irreparable outcomes. Early identification of patients with serious symptoms who may develop critical illness and even death is of considerable importance for personalizing treatment and balancing medical resources.Methods: In this retrospective study, demographic, clinical characteristics and laboratory tests from 726 patients with serious COVID-19 from Tongji Hospital (Wuhan, China) were analyzed. The standards for the serious type are guided by the Chinese management guideline for COVID-19. Patients were classified into critical group (174 cases) and severe group (552 cases) based on whether the composite endpoint was reached, and the former group was divided into the survivors (47 cases) and non-survivors (127 cases). Univariable and multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were performed to investigate the risk factors associated with poor prognosis and mortality outcomes.Results: Male patients accounted for 62.1% and 51.6% in the critical group and severe group, with a median age of 68 and 65 years, respectively. Among critical cases there was a higher prevalence of chronic obstructive lung disease (p = 0.029) and chest distress (p = 0.040) than in severe cases. In the multivariable analysis, the risk factors associated with poor prognosis in severe cases were advanced age (p = 0.002), high respiratory rate (RR) (p < 0.0001), high lactate dehydrogenase (LDH) level (p = 0.021), high hypersensitive cardiac troponin I (hs-cTnI) level (p < 0.0001), and low platelet counts (p = 0.005) at admission. In the adjusted models, higher mortality outcomes in critical patients were associated with high hs-cTnI level (p = 0.037). By plotting ROC curves of different indices, hs-cTnI and LDH were found to be predictive factors for poor prognosis in patients with severe COVID-19.Conclusions: For the risk assessment of serious COVID-19 patients on admission, advanced age, high level of RR, LDH, hs-cTnI, and low platelet counts, constitute important risk factors for poor prognosis in severe cases, and the hs-cTnI level can be helpful in predicting fatal outcomes in critically ill patients.
Exploring the potential for item banking in assessing quality of life for evaluating adolescent health interventions
Authors: Khadka Jyoti , Chen Gang , Ratcliffe Julie 
Published: August 2020

Abstract
Background

To develop and validate an item bank using existing items from both preference and non-preference-based health-related quality of life (HRQoL) instruments targeted for application with adolescent populations.
Methods

Australian adolescents completed the Child Health Utility 9D (CHU9D), demographic details, self-rated health status, disability and one other instrument (either preference-based: Health Utilities Index (HUI) or EuroQoL-5 Dimension-Youth (EQ-5D-Y) or Assessment of Quality of Life (AQoL)-6D Adolescent or non-preference-based: Pediatric Quality of Life Inventory (PedsQL) Short Form 15 or KIDSCREEN-10) using online survey portals. Data from all the instruments were pooled together to create an item bank, which was then subjected to Rasch analysis to tests its psychometric properties. Validity of the item bank was assessed by testing its ability to discriminate varying levels of self-reported health, disability and socio-economic status (as approximated by the Family Affluence Scale).
Results

A total of 4,352 Australian adolescents aged 11–17 years from the general population participated. The CHU9D (common instrument) items were used as anchor items to create the item bank. Rasch analysis demonstrated that 2 of the 75 items (2.7%) misfit and were removed from the item bank. The 73-item item bank had adequate precision, no misfitting items, no item bias and demonstrated sufficient unidimensionality. In general boys exhibited higher HRQoL scores than girls (p = 0.001). More severe health status/disability and lower socio-economic status being associated with lower HRQoL (p < 0.0001).
Conclusions

The item bank demonstrated adequate Rasch-based psychometric properties and validity demonstrating the feasibility of the construction of an item bank in this context. The addition of more targeted items for adolescents in the general population and the addition of participants with more health impairments may improve the general applicability of the item bank for both general population and patient cohorts.
Species Structure, Diversity, and Tree Regeneration on Stumps in Second-Growth Temperate Rainforests of British Columbia, Canada
Authors: Wang Qing , Srivast Vivek , Super Laura , Wang Tongli , El-Kassaby Yousry A. 
Published: August 2020

Abstract
Background: The significance of stumps and other coarse woody debris (CWD) in maintaining biodiversity has been widely recognized. However, there is a paucity of research on the role of stumps in tree regeneration. We studied vascular plant structure, diversity, and tree regeneration on stumps in temperate rainforests across three sites in British Columbia, Canada (Malcom Knapp Research Forest, MKRF; Pacific Spirit Regional Park, PSRP; and Stanley Park, SP).Results: 1) There were 19 vascular plant species found on stumps, including eight tree species, 2) Overall seedling abundance was higher on stumps than the nearby ground, 3) The number of established plants showed a positive linear (MKRF, SP) or Gaussian (PSRP) relationship with stump basal diameter, 4) Vegetation abundance varied with site (MKRF > SP > PSRP), 5) The overall species established on stumps were positively associated in MKRF (Variance ratio = 2.74) and SP (Variance ratio = 1.37), but negatively associated in PSRP (Variance ratio = 0.57), and 6) Tree species appeared to compete with each other on stumps and were likely to co-occur with understorey species.Conclusion: Our results highlight community and species associations on stumps. We found that stump diameter is a major factor affecting tree regeneration in these second-growth temperate rainforests. To aid future research on stump-vegetation relationships, we synthesize our results in a schematic of vascular plant biodiversity and tree regeneration on stumps. Our work and this schematic can be used to stimulate ideas for new hypothesis generation and for studies relevant for conservation, management and basic science research.
Enhancing Early Engagement (E3) in Mental Health Services Training for Children's Advocacy Center's Victim Advocates: Protocol for a Randomized Clinical Trial
Authors: Taylor Erin K , Dopp Alex R , Lounsbury Kaitlin , Thompson Yutian , Miller Michelle , Jorgensen Ashley G. , Silovsky Jane F 
Published: August 2020

Abstract
Background: Child maltreatment is a major public issue in the United States, yet most children affected by abuse or neglect never engage in evidence-based practices (EBP) for child mental health. Children’s Advocacy Centers (CACs’) are uniquely situated to serve as Family Navigators who connect children impacted by maltreatment to appropriate EBPs. In fact, the CAC position of Victim Advocate mirrors the Mental Health Family Navigator national initiative. Methods: We will develop, implement, and evaluate web-based and consultative training for Victim Advocates to enhance early engagement in services (E3 training). The interactive web-based training will embed key targets of knowledge and skills related to family engagement, trauma, and EBP services. Participating CACs will be randomized to E3 webinar-based training, E3 webinar plus consultation, or delayed training. The project will test the E3 training’s impact on key mechanisms of change (e.g., knowledge, skills) to improve rates of screening, referral, and access to EBP services. The feasibility of implementing the training program, and differential impact and costs by level of training will be examined.Discussion: The overarching goal of this project is to test a training that is readily implemented through CACs and examine the mechanisms for improving early engagement and, ultimately, child and adolescent mental health outcomes. Results and cost findings will be used to plan a large-scale comprehensive, mixed-methods Hybrid Type II effectiveness-implementation and cost-effectiveness trial of Family Navigator E3 training. If outcomes are positive, considerable infrastructure exists to support the scale-up and sustainability of E3 training nationwide, by embedding the training in national CAC training protocols.Trial registration: NCT04221633
The COVID-19 Pandemic in Francophone West Africa: From the First Cases to Responses in Seven Countries
Authors: Bonnet Emmanuel , Bodson oriane , Marcis Fréderic Le , Faye Adama , Sambieni Emmanuel , Fournet Florence , Boyer Florence , Coulibaly Abdourahmane , Kadio Kadidiatou , Diongue Fatoumata Binetou , Ridde Valery 
Published: August 2020

Abstract
Background: In early March 2020, the COVID-19 pandemic hit West Africa. Countries in the region quickly set up crisis management committees and organised drastic measures to stem the spread of the coronavirus. The objective of this article is to analyse the epidemiological evolution of COVID-19 in seven Francophone West African countries (Benin, Burkina Faso, Côte d'Ivoire, Guinea, Mali, Niger, Senegal) as well as the public health measures decided upon during the first four months of the pandemic. Methods: Our method is based on quantitative and qualitative data from the pooling of information from a COVID-19 data platform and collected by a network of interdisciplinary collaborators present in the seven countries. Descriptive and spatial analyses of quantitative epidemiological data and content analyses of qualitative data on public measures and management committees were performed. Results: Attack rates for COVID-19 range from less than 10 per 100,000 inhabitants (Benin) to more than 45 per 100,000 inhabitants (Guinea). The spatio-temporal analysis shows three phases of incidence clusters. By the end of June 2020, case numbers had plateaued in some countries (Burkina Faso, Niger, Mali) while others continued to see the number of infections increasing (Benin, Côte d'Ivoire, Guinea, Senegal). The countries all reacted quickly to the crisis, in some cases before the first reported infection, and implemented public measures in a relatively homogeneous manner. None of the countries implemented country-wide lockdowns, but in some cases implemented partial or local containment measures. At the end of June 2020, countries began to lift certain restrictive measures, sometimes under pressure from the general population or from certain economic sectors. All the countries have adopted response plans and organized multiple crisis management committees, although their content and functioning have not always been transparent or easy to understand. Conclusion: Much research remains to be done in West Africa. It will be necessary to better understand the dynamics of the pandemic, which appears to be largely under control, as well as the effectiveness and implementation of the state responses, which have been rapidly formulated.