bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Pain in Keloids Using Only a Long‐Pulsed 1064 nm Nd:YAG Laser
Authors: Patel Payal M. , Bakus Abnoeal D. , Garden Benjamin C. , Lai Olivia , Jones Virginia A. , Garden Jerome M. 
Published: November 2020

Background and ObjectiveKeloids are benign lesions arising from overproduction of the extracellular matrix and abnormal collagen deposition by dermal fibroblasts. This altered wound healing typically occurs in response to dermal trauma. Keloid treatment poses a challenge due to the variable nature of treatment response, which can be affected by the size, appearance, and associated symptoms of erythema, pruritus, and pain. Recently, successful treatment of keloids has been reported using the Nd:YAG laser in conjunction with 5‐fluorouracil and intralesional corticosteroids. We present a series of patients with symptomatic keloids, who we treated with only a 1064 nm Nd:YAG laser.Study Design/Materials and MethodsEight patients of Fitzpatrick skin types I–VI presented for treatment of keloids with associated symptoms of pain. The keloids were most commonly located on the trunk, and seven patients had intralesional steroid injections prior to presentation with persistence of symptoms. Patient treatment consisted of two passes under a long‐pulsed 1064 nm Nd:YAG laser with a 10 mm spot size, a fluence of 18–19 J/cm2, and 60 ms pulse duration every 3–8 weeks. Patient‐reported pain scores were collected before and after treatment.ResultsFollowing treatment, transient erythema and mild edema were noted at the treatment site. All patients reported improvement in the symptoms of pain, with an average of a 5‐point reduction using a 10‐point scale (R: 2–10). Five out of eight patients had total resolution of their pain. An average of 3.25 treatments (R:1–5) were needed for patients to first notice an improvement in the pain. A Wilcoxon signed‐rank test showed that treatment with a 1064 nm laser elicited a statistically significant improvement in pain in individuals with keloids (Z = 2.46, P = 0.01). No patients in our study suffered any scarring or pigment changes as a result of these treatments.ConclusionKeloids are a common condition with variable rates of treatment satisfaction. Lasers have been used in an attempt to improve clinical appearance and associated symptoms. We report a significant reduction in pain for patients treated exclusively with a 1064 nm Nd:YAG laser. Lasers Surg. Med. © 2020 Wiley Periodicals LLC
Sources of get information and related factors during pregnancy among Afghan migrant women in Iran
Authors: Sharifi Mahnaz , Amiri‐Farahani Leila , Kariman Nourossadat , Hasanpoor‐Azghady Syedeh Batool , Amiri‐Farahani Mina 
Published: November 2020

AbstractAimThe present study aims to investigate the sources of information and its related factors among pregnant Afghan migrant women who reside in southeast Tehran Province, Iran.DesignCross‐sectional study.MethodsA total of 280 pregnant Afghan women who received care at the prenatal clinics of selected healthcare centres in southeast Tehran Province (Iran) in 2018 enrolled in this study. Data were collected by continuous sampling by a questionnaire that asked about demographic, obstetric and sources of information used during pregnancy.ResultsThe most important sources of information accessed by pregnant Afghan women were healthcare providers (65.1%), family and friends (47.55%), the Internet (32.1%) and media (18.9%). There was statistically a significant relationship between sources of information and education level, number of children, length of residence in Iran, place of birth and insurance status.
A fuzzy solution of wave equation by FFS‐transform
Authors: Allahviranloo Tofigh , Ghobadi Mostafa , Matinfar Mashallah 
Published: November 2020

AbstractIn this paper, we introduce a fuzzy Fourier sine transform decomposition as an analytical solution of a fuzzy wave equation under generalized Hukuhara partial differentiability. Since the fuzzy transforms have already been proven to solve several problems in different fields, they propel us to utilize them as a practical and appropriate way to solve the wave equation. The theorems and properties are demonstrated in detail, then the efficiency of the proposed approach is confirmed through solving several examples.
Examining the effects of the personal matrix activity with diverse students
Authors: Muldrew Alexandria C. , Miller Faith G. 
Published: November 2020

AbstractTier 1 implementation of Positive Behavioral Interventions and Supports (PBIS) focuses on developing, teaching, and reinforcing school‐wide behavioral expectations. Yet, it is unclear whether expectations align with the cultural experiences of students from diverse backgrounds. The Personal Matrix Activity (PMA) provides students with an opportunity to describe behavioral expectations across settings and is intended to help bridge cultural gaps that may exist between school and other contexts. The purpose of this study was to examine the acceptability, feasibility, and preliminary efficacy of the PMA with culturally and linguistically diverse (CLD) students in a school already implementing PBIS. Participating classrooms (N = 4) consisted of students (N = 74) who all identified as nonwhite and the majority of whom (81%) were non‐native English speakers. A multiple baseline design across classrooms was implemented with Direct Behavior Rating – Single Item Scales targeting class‐wide respectful and disruptive behavior as primary outcomes. Both visual and quantitative analyses illustrated the class‐wide behaviors of CLD students improved after implementation of the PMA. The PMA appeared feasible to implement and preliminary evidence of effects indicate promise. Future research evaluating the PMA and other culturally responsive PBIS practices is warranted.
Proteomics in the COVID‐19 Battlefield: First Semester Check‐Up
Authors: Grenga Lucia , Armengaud Jean 
Published: November 2020

AbstractProteomics offers a wide collection of methodologies to study biological systems at the finest granularity. Faced with COVID‐19, the most worrying pandemic in a century, proteomics researchers have made significant progress in understanding how the causative virus hijacks the host's cellular machinery and multiplies exponentially, how the disease can be diagnosed, and how it develops, as well as its severity predicted. Numerous cellular targets of potential interest for the development of new antiviral drugs have been documented. Here, the most striking results obtained in the proteomics field over this first semester of the pandemic are presented. The molecular machinery of SARS‐CoV‐2 is much more complex than initially believed, as many post‐translational modifications can occur, leading to a myriad of proteoforms and a broad heterogeneity of viral particles. The interplay of protein–protein interactions, protein abundances, and post‐translational modifications has yet to be fully documented to provide a full picture of this intriguing but lethal biological threat. Proteomics has the potential to provide rapid detection of the SARS‐CoV‐2 virus by mass spectrometry proteotyping, and to further increase the knowledge of severe respiratory syndrome COVID‐19 and its long‐term health consequences.
Interprofessional Practitioners' Opinions on Features and Services for an Augmentative and Alternative Communication Brain‐Computer Interface Device
Authors: Hill Katya , Huggins Jane , Woodworth Chelsea 
Published: November 2020

BackgroundBrain‐computer interface (BCI) technology is an emerging access method to augmentative and alternative communication (AAC) devices.ObjectivesTo identify, in the early stages of research and development, the perceptions and considerations of interprofessional practice (IPP) team members regarding features and functions for an AAC‐BCI device.DesignQualitative research methodology applying a grounded theory approach using focus groups with a follow‐up survey of participants using NVivo analysis software supporting inductive coding of transcription data.SettingFocus groups held at university, clinic, and industry conference rooms. Discussion was stimulated by a 14‐minute video on an AAC‐BCI device prototype. The prototype hardware and electroencephalography (EEG) gel and dry electrode headgear were on display.ParticipantsConvenience sample of practitioners providing rehabilitation or clinical services to individuals with severe communication disorders and movement impairments who use AAC and/or other assistive technology.InterventionsNot applicable.Main Outcome MeasuresDescriptive statistics using thematic analysis of participants' opinions, input, and feedback on the ideal design for a noninvasive, EEG‐based P300 AAC‐BCI device.ResultsInterrater and interjudge reliability were at 98% and 100%, respectively, for transcription and researcher coding. Triangulation of multiple data sources supported theme and subtheme identification that included design features, set‐up and calibration, services, and effectiveness. An AAC device with BCI access was unanimously confirmed (100%) as a desirable commercial product. Participants felt that the AAC‐BCI prototype appeared effective for meeting daily communication needs (75%). Results showed that participants' preference on headgear types would change based on accuracy (91%) and rate (83%) of performance. A data‐logging feature was considered beneficial by 100% of participants.ConclusionsIPP teams provided critical impressions on design, services, and features for a commercial AAC‐BCI device. Expressed feature and function preferences showed dependence on communication accuracy, rate, and effectiveness. This provides vital guidance for successful clinical deployment.
Unmet needs from the first diagnosis of cancer until the end of medical treatment: A longitudinal study
Authors: Gao Yuhan , Zhu Lei , Xie Juan , Liu Ailan , Ding Yanni , Yao Juntao 
Published: November 2020

AbstractObjectiveThis study aimed to examine (1) The courses of Chinese cancer patients' unmet supportive care needs (psychological, physical and daily living, health system and information, patient care and support, and sexual) from the first cancer diagnosis until the end of medical treatment; (2) The predictive role of socio‐demographic and medical characteristics (i.e., age, gender, and cancer stage) in the courses of unmet needs; and (3) The associations of courses of unmet needs with courses of depressive and anxiety symptoms.MethodsA longitudinal study was performed at Shaanxi Provincial Tumour Hospital in Xi'an, China. A total of 153 heterogeneous cancer patients were assessed after the first diagnosis (T1), at the beginning (T2) and the end (T3) of the receipt of medical treatment. Latent growth curve models were used to examine the research questions.ResultsPsychological needs and health system and information needs showed a decrease over time, whereas physical needs, patient care needs and sexual needs remained stable. Younger and female patients tended to report higher levels of unmet psychological needs at T1 and experienced slower decreases from T1 to T3. Only the courses of unmet psychological needs were associated with the courses of depressive and anxiety symptoms from T1 to T3.ConclusionsMore attention can be given to young and female cancer patients, as they were more likely to suffer from high unmet psychological needs over the disease trajectory. Future research may focus more on addressing unmet needs reported by Chinese cancer patients.
An Experimental Comparison of Selected Blue Flame Pyrotechnics
Authors: Juknelevicius Dominykas , Hahma Arno , Webb Rutger , Klapötke Thomas M. , Ramanavicius Arunas 
Published: November 2020

AbstractIn this research, 10 different pyrotechnic blue flame compositions were designed and compared. Chromaticity and luminosity parameters of the flame were measured using Ocean Optics JAZ‐ULM VIS‐Spectrometer equipped with a cosine corrector. Color saturation, luminous intensity, specific luminous intensity, oxygen balance, burn rate, actual and theoretical maximum density, color coordinates (X, Y) are presented and discussed.
Crystal structure of PYCH_01220 from Pyrococcus yayanosii potentially involved in binding nucleic acid
Authors: Noh Haemin , Jeon Jae‐Hyun , Kim Yeon‐Gil , Oh Byung‐Ha 
Published: November 2020

AbstractWe report the crystal structure of PYCH_01220, a hypothetical protein in Pyrococcus yayanosii CH1. This protein is composed of two domains, named Domain A and Domain B. While Domain B is not significantly homologous to known protein structures, Domain A is structurally analogous to the C‐terminal ribonuclease domain of Escherichia coli colicin D. Domain A has a positively charged surface patch rendered by 13 basic residues, eight arginine or lysine residues of which are evolutionarily conserved. Electrophoretic mobility shift assays showed that PYCH_01220 binds to DNA, and charge‐inversion mutations on this patch negatively affect the DNA binding, suggesting that the function of PYCH_01220 might involve nucleic acid‐binding via the positively charged patch.
Extending the footprint record of Pareiasauromorpha to the Cisuralian: earlier appearance and wider palaeobiogeography of the group
Authors: Marchetti Lorenzo , Voigt Sebastian , Mujal Eudald , Lucas Spencer G. , Francischini Heitor , Fortuny Josep , Santucci Vincent L. 
Published: November 2020

AbstractPareiasauromorpha is one of the most important tetrapod groups of the Permian. Skeletal evidence suggests a late Kungurian origin in North America, whereas the majority of occurrences come from the Guadalupian and Lopingian of South Africa and Russia. However, Pareiasauromorpha footprints include the ichnogenus Pachypes, which is unknown from strata older than late Guadalupian. A revision of several Pachypes‐like footprints from the Cisuralian–Guadalupian of Europe and North America confirm the occurrence of this ichnogenus and of the ichnospecies Pachypes ollieri comb. nov. beginning in the Artinskian. This is the earliest known occurrence of Pachypes and it coincides with the Artinskian reptile radiation. Based on a synapomorphy‐based track–trackmaker correlation, P. ollieri can be attributed to nycteroleter pareiasauromorphs such as Macroleter. Therefore, the earliest occurrences of pareiasauromorph footprints precede by at least 10 myr the earliest occurrence of this group in the skeletal record. Moreover, the palaeobiogeography of the group is extended to the Cisuralian and Guadalupian of western Europe.
Examining the relationship between the Educative Teacher Performance Assessment and preservice teachers' pedagogical content knowledge
Authors: Reynolds Wm. Matthew , Park Soonhye 
Published: November 2020

AbstractThis study examined the relationship between preservice teachers' Educative Teacher Performance Assessment (edTPA) scores, the most widely implemented preservice teacher performance assessment in the United States, and the pedagogical content knowledge (PCK) levels reflected in their edTPA portfolios. PCK is a specialized form of teacher professional knowledge widely considered a paramount construct of teacher quality. Thirty‐six preservice science teachers' PCK levels were determined by analyzing their edTPA portfolios, including videos and written commentaries, with the PCK mapping approach, an enumerative analytical method capable of quantifying and visualizing the integration of PCK components. Data analysis indicates there was a significant positive correlation between participants' edTPA scores and their PCK levels (rs[36] = 0.949, p < 0.0001). Through further analysis, this study also identified several key features of preservice teachers' PCK revealed in their edTPA portfolios: (1) preservice science teachers' Knowledge of Student's Understanding (KSU) and Knowledge of Instructional Strategies and Representations (KISR) were the most developed components of PCK; (2) accounting for over 50% of all connections between PCK components, KSU, KISR, and Knowledge of Assessments were among the most frequently integrated components of PCK; (3) Knowledge of Science Curriculum was the least frequently integrated, and therefore the weakest, component of preservice teachers' PCK; and (4) inquiry was the most frequently mentioned, and typically the only Orientation toward Teaching Science found in participants' edTPA materials. This study contributes to the growing body of scholarship on the characteristics of preservice science teachers' PCK and becomes one of only a handful of empirical studies that examine the edTPA's diagnostic abilities. Finally, potential implications regarding the edTPA in science teacher education, as well as directions for future research surrounding preservice science teacher PCK and PCK development, are discussed.
uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells
Authors: Biagioni Alessio , Laurenzana Anna , Menicacci Beatrice , Peppicelli Silvia , Andreucci Elena , Bianchini Francesca , Guasti Daniele , Paoli Paolo , Serratì Simona , Mocali Alessandra , Calorini Lido , Del Rosso Mario , Fibbi Gabriella , Chillà Anastasia , Margheri Francesca 
Published: November 2020

AbstractExosomes (Exos) have been reported to promote pre-metastatic niche formation, proliferation, angiogenesis and metastasis. We have investigated the role of uPAR in melanoma cell lines-derived Exos and their pro-angiogenic effects on human microvascular endothelial cells (HMVECs) and endothelial colony-forming cells (ECFCs). Melanoma Exos were isolated from conditioned media of A375 and M6 cells by differential centrifugation and filtration. Tunable Resistive Pulse Sensing (TRPS) and Nanoparticle tracking analysis were performed to analyze dimension and concentration of Exos. The CRISPR–Cas 9 technology was exploited to obtain a robust uPAR knockout. uPAR is expressed in melanoma Exos that are internalized by HMVECs and ECFCs, enhancing VE-Cadherin, EGFR and uPAR expression in endothelial cells that undergo a complete angiogenic program, including proliferation, migration and tube formation. uPAR loss reduced the pro-angiogenic effects of melanoma Exos in vitro and in vivo by inhibition of VE-Cadherin, EGFR and uPAR expression and of ERK1,2 signaling in endothelial cells. A similar effect was obtained with a peptide that inhibits uPAR–EGFR interaction and with the EGFR inhibitor Gefitinib, which also inhibited melanoma Exos-dependent EGFR phosphorylation. This study suggests that uPAR is required for the pro-angiogenic activity of melanoma Exos. We propose the identification of uPAR-expressing Exos as a potentially useful biomarker for assessing pro-angiogenic propensity and eventually monitoring the response to treatment in metastatic melanoma patients.
Multilevel ensemble Kalman filtering for spatio-temporal processes
Authors: Chernov Alexey , Hoel Håkon , Law Kody J. H. , Nobile Fabio , Tempone Raul 
Published: November 2020

AbstractWe design and analyse the performance of a multilevel ensemble Kalman filter method (MLEnKF) for filtering settings where the underlying state-space model is an infinite-dimensional spatio-temporal process. We consider underlying models that needs to be simulated by numerical methods, with discretization in both space and time. The multilevel Monte Carlo sampling strategy, achieving variance reduction through pairwise coupling of ensemble particles on neighboring resolutions, is used in the sample-moment step of MLEnKF to produce an efficent hierarchical filtering method for spatio-temporal models. Under sufficent regularity, MLEnKF is proven to be more efficient for weak approximations than EnKF, asymptotically in the large-ensemble and fine-numerical-resolution limit. Numerical examples support our theoretical findings.
Conservative treatment versus elective repair of umbilical hernia in patients with liver cirrhosis and ascites: results of a randomized controlled trial (CRUCIAL trial)
Authors: de Goede B. , van Rooijen M. M. J. , van Kempen B. J. H. , Polak W. G. , de Man R. A. , Taimr P. , Lange J. F. , Metselaar H. J. , Kazemier G. 
Published: November 2020

Abstract
Purpose
To establish optimal management of patients with an umbilical hernia complicated by liver cirrhosis and ascites.

Methods
Patients with an umbilical hernia and liver cirrhosis and ascites were randomly assigned to receive either elective repair or conservative treatment. The primary endpoint was overall morbidity related to the umbilical hernia or its treatment after 24 months of follow-up. Secondary endpoints included the severity of these hernia-related complications, quality of life, and cumulative hernia recurrence rate.

Results
Thirty-four patients were included in the study. Sixteen patients were randomly assigned to elective repair and 18 to conservative treatment. After 24 months, 8 patients (50%) assigned to elective repair compared to 14 patients (77.8%) assigned to conservative treatment had a complication related to the umbilical hernia or its repair. A recurrent hernia was reported in 16.7% of patients who underwent repair. For the secondary endpoint, quality of life through the physical (PCS) and mental component score (MCS) showed no significant differences between groups at 12 months of follow-up (mean difference PCS 11.95, 95% CI − 0.87 to 24.77; MCS 10.04, 95% CI − 2.78 to 22.86).

Conclusion
This trial could not show a relevant difference in overall morbidity after 24 months of follow-up in favor of elective umbilical hernia repair, because of the limited number of patients included. However, elective repair of umbilical hernia in patients with liver cirrhosis and ascites appears feasible, nudging its implementation into daily practice further, particularly for patients experiencing complaints.

Trial registration
Clinicaltrials.gov, NCT01421550, on 23 August 2011.
Impact probability under aleatory and epistemic uncertainties
Authors: Tardioli Chiara , Farnocchia Davide , Vasile Massimiliano , Chesley Steve R. 
Published: November 2020

AbstractWe present an approach to estimate an upper bound for the impact probability of a potentially hazardous asteroid when part of the force model depends on unknown parameters whose statistical distribution needs to be assumed. As case study, we consider Apophis’ risk assessment for the 2036 and 2068 keyholes based on information available as of 2013. Within the framework of epistemic uncertainties, under the independence and non-correlation assumption, we assign parametric families of distributions to the physical properties of Apophis that define the Yarkovsky perturbation and in turn the future orbital evolution of the asteroid. We find$${\mathrm{IP}}\le 5\times 10^{-5}$$IP≤5×10-5for the 2036 keyhole and$${\mathrm{IP}}\le 1.6\times 10^{-5}$$IP≤1.6×10-5for the 2068 keyhole. These upper bounds are largely conservative choices due to the rather wide range of statistical distributions that we explored.