bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les nouveaux mouvements constitutionnels dans le monde arabe (2011-2016)
Authors: Boumédiene Malik 
Published: December 2019

Le monde arabe rencontre, depuis 2011, un certain nombre de bouleversements importants : bouleversements sociétaux ; économiques ; politiques ; constitutionnels. Ce sont ces derniers qui ont attiré, avant tout, l’attention du juriste. À travers cette étude il s’agit de tenter de mettre en lumière les grandes dynamiques constitutionnelles qui touchent un certain nombre de pays arabes. L’analyse de cette période parait montrer que deux grandes orientations semblent prédominer : La volonté de consolider les droits fondamentaux d’une part et, d’autre part, la nécessité d’assurer un meilleur équilibre entre le pouvoir exécutif et législatif. Si cette volonté est réelle il faut aussi souligner que le chemin restant à parcourir est encore important. En effet, ces dynamiques juridiques non seulement doivent être relativisées mais elles doivent faire face à des dynamiques politiques conservatrices.
An Early Neutrophil Recruitment into the Infectious Site Is Critical for Bacterial Lipoprotein Tolerance–Afforded Protection against Microbial Sepsis
Authors: Chen Wenting , Zhao Shuqi , Ita Michael , Li Yue , Ji Jingjing , Jiang Yong , Redmond H. Paul , Wang Jiang Huai , Liu Jinghua 
Published: December 2019

Abstract
Bacterial lipoprotein (BLP)–induced tolerance represents an essential regulatory mechanism during bacterial infection and has been shown to protect against microbial sepsis. This protection is generally attributed to BLP-tolerized monocytes/macrophages characterized by hyporesponsiveness in producing inflammatory cytokines and, simultaneously, an augmented antimicrobial activity. However, the contribution of polymorphonuclear neutrophils (PMNs), another major player in innate immunity against bacterial infection, to BLP tolerance–afforded protection against microbial sepsis has not been identified. In this study, we report that induction of BLP tolerance protected mice against cecal ligation and puncture–induced polymicrobial sepsis, with significantly improved survival. Importantly, BLP tolerization via i.p. injection triggered an early PMN recruitment even before bacterial infection and promoted further PMN influx into the infectious site (i.e., the peritoneal cavity upon cecal ligation and puncture–associated septic challenge). Notably, this early PMN influx was mediated by BLP tolerization–induced PMN chemoattractant CXCL2-formed concentration gradient between the circulation and peritoneal cavity. Critically, blockage of PMN influx with the CXCR2 antagonist SB225002 abolished BLP tolerance–afforded protection and rendered BLP-tolerized mice more vulnerable to microbial infection with impaired bacterial clearance and increased overall mortality. Thus, our results highlight that an early recruitment of PMNs in the infectious site, as an important cellular mechanism, contributes to BLP tolerance–afforded protection against microbial sepsis.
Activation of TCR Vδ1+ and Vδ1−Vδ2− γδ T Cells upon Controlled Infection with Plasmodium falciparum in Tanzanian Volunteers
Authors: Rutishauser Tobias , Lepore Marco , Di Blasi Daniela , Dangy Jean-Pierre , Abdulla Salim , Jongo Said , Ramadhani Kamaka , Sim B. Kim Lee , Hoffman Stephen L. , Tanner Marcel , Daubenberger Claudia , De Libero Gennaro 
Published: December 2019

Abstract
Our understanding of the human immune response to malaria remains incomplete. Clinical trials using whole-sporozoite-based vaccination approaches such as the Sanaria PfSPZ Vaccine, followed by controlled human malaria infection (CHMI) to assess vaccine efficacy offer a unique opportunity to study the immune response during Plasmodium falciparum infection. Diverse populations of T cells that are not restricted to classical HLA (unconventional T cells) participate in the host response during Plasmodium infection. Although several populations of unconventional T cells exist, the majority of studies focused on TCR Vγ9Vδ2 cells, the most abundant TCR γδ cell population in peripheral blood. In this study, we dissected the response of three TCR γδ cell subsets and mucosal-associated invariant T cells in healthy volunteers immunized with PfSPZ Vaccine and challenged by CHMI using Sanaria PfSPZ Challenge. Using a flow cytometry-based unbiased analysis followed by T cell cloning, several findings were made. Whereas major ex vivo alterations were not detectable after immunization with PfSPZ Vaccine, TCR Vδ2, and mucosal-associated invariant T cells expanded after asexual blood-stage parasitemia induced by CHMI. CHMI, but not vaccination, also induced the activation of TCR Vδ1 and Vδ1−Vδ2− γδ T cells. The activated TCR Vδ1 cells were oligoclonal, suggesting clonal expansion, and upon repeated CHMI, showed diminished response, indicating long-term alterations induced by blood-stage parasitemia. Some TCR Vδ1 clones recognized target cells in the absence of parasite-derived Ags, thus suggesting recognition of self-molecules. These findings reveal the articulate participation of different populations of unconventional T cells to P. falciparum infection.
Diacylglycerol Kinase ζ Regulates Macrophage Responses in Juvenile Arthritis and Cytokine Storm Syndrome Mouse Models
Authors: Mahajan Sahil , Mellins Elizabeth D. , Faccio Roberta 
Published: December 2019

Abstract
Dysregulation of monocyte and macrophage responses are often observed in children with systemic juvenile idiopathic arthritis (sJIA) and cytokine storm syndrome (CSS), a potentially fatal complication of chronic rheumatic diseases. Both conditions are associated with activation of TLR signaling in monocyte and macrophage lineage cells, leading to overwhelming inflammatory responses. Despite the importance of TLR engagement in activating proinflammatory macrophages, relatively little is known about activation of intrinsic negative regulatory pathways to attenuate excessive inflammatory responses. In this study, we demonstrate that loss of diacylglycerol (DAG) kinase (Dgk) ζ, an enzyme which converts DAG into phosphatidic acid, limits inflammatory cytokine production in an arthritic mouse model dependent on TLR2 signaling and in a CSS mouse model dependent on TLR9 signaling. In vitro, Dgkζ deficiency results in reduced production of TNF-α, IL-6, and IL-1β and in limited M1 macrophage polarization. Mechanistically, Dgkζ deficiency decreases STAT1 and STAT3 phosphorylation. Moreover, Dgkζ levels are increased in macrophages derived from mice with CSS or exposed to plasma from sJIA patients with active disease. Our data suggest that Dgkζ induction in arthritic conditions perpetuates systemic inflammatory responses mediated by macrophages and highlight a potential role of Dgkζ–DAG/phosphatidic acid axis as a modulator of inflammatory cytokine production in sJIA and CSS.
Smokeless Tobacco Warnings in Indian Mass Media: Intention and Attempts to Quit
Authors: Madewell Zachary J. , Kolaja Claire A. 
Published: December 2019

AbstractIntroduction: In India, over 200 million people use smokeless tobacco (SLT), which increases the risk of cancers. Studies have demonstrated mass media campaigns effectively reduce smoking tobacco prevalence, but few have assessed their impact on SLT cessation. Objectives: This study used data from the Global Adult Tobacco Surveys (GATS) in 2009–2010 and 2016–2017 to examine associations between SLT health warnings in mass media, and intention and attempts to quit using SLT. We also compared the proportion of SLT users who noticed mass media warnings between 2009–2010 and 2016–2017. Materials and Methods: Over 16,000 and 15,000 current SLT users from the GATS-1 and GATS-2, respectively, were used for analysis. Weighted logistic regression models were used to analyze associations between noticed health warnings on SLT packages, newspapers/magazines, television, radio, billboards, cinemas, internet, vehicles, and walls, and intention and attempts to quit SLT. Results: In final models, the odds of intention and attempts to quit were highest among those who noticed warnings in newspapers/magazines (adjusted odds ratio [AOR]: 1.50; 95% confidence interval [CI]: 1.30–1.74) and the internet (AOR: 1.60; 95% CI: 1.12–2.29), respectively. Warnings on SLT packages, television, billboards, radio, vehicles, and walls were also associated with increased cessation behavior. More noticed warnings on SLT packages, television, billboards, and newspapers/magazines in GATS-2 than GATS-1, but fewer heard radio warnings. Conclusions: Among Indian SLT users, we found evidence that SLT warnings in mass media may promote cessation behavior. Health warnings in mass media could play an important role in the overall strategy to reduce the morbidity and mortality associated with SLT use.
A Prospective Randomized Comparison of Concurrent Chemoradiation with Neoadjuvant and Adjuvant Chemotherapy with Concurrent Chemoradiation Alone for Locally Advanced Carcinoma Cervix
Authors: Singh Rahul , Bhatt M LB , Kumar Rajendra , Srivastava Kirti , Grover R K , Shukla Pragya , Raturi Vijay P , Gaur Jalaj , Saha Mandira , Kishan Dewesh ,   Roopali
Published: December 2019

Abstract
Aims: The aim of this study was to compare concurrent chemoradiation along with neoadjuvant and adjuvant chemotherapy versus concurrent chemoradiation alone in locally advanced cervical cancer regarding treatment response and toxicities. Subjects and Methods: A randomized control study was done on 116 patients with locally advanced carcinoma cervix (Stage IIB to IIIB) registered between January 2014 and February 2015. Patients were randomly divided to receive either one cycle of cisplatin/5-fluorouracil neoadjuvant chemotherapy and two cycles of the same adjuvant chemotherapy with concurrent chemoradiation with weekly cisplatin (Arm A) or only concurrent chemoradiation (Arm B). All patients received three fractions of high-dose-rate intracavitary brachytherapy after completion of the external radiation. Results: A higher proportion of the patients of chemotherapy arm achieved complete response (94%) as compared to the nonchemotherapy arm (56%), and this was statistically significant. There was a trend toward more treatment-related acute toxicity with chemotherapy. Conclusions: These results have corroborated the view that if neoadjuvant and adjuvant chemotherapies are added to concurrent chemoradiation, it could further the effects of concurrent chemoradiation for patients with locally advanced cancer of the uterine cervix.
Efficacy of a Reduced-dose Rasburicase: Single-institution Experience in India
Authors: Lakshmaiah K C , Babu K Govind , Rajeev L K , Loknatha D , Abraham Linu Jacob , Babu M C Suresh , Lokesh K N , Rudresha A H , Agarwal Ankit 
Published: December 2019

Abstract
Background: Tumor lysis syndrome (TLS) is an oncological emergency associated with life-threatening metabolic abnormalities. Hyperuricemia is a feature of TLS and is treated with hydration, urine alkalinization, and allopurinol. Rasburicase lowers uric acid (UA) rapidly at the labeled dose of 0.15–0.2 mg/kg/day for 5 days. In a developing country like India where affordability is one major limitation to medical care, the use of rasburicase at the dose recommended by the US Food and Drug Administration (FDA) is not always possible. There is no convincing data suggesting the efficacy of a lower dose of rasburicase (1.5 mg or 3 mg) in the treatment of TLS. We conducted a retrospective study from January 2015 to June 2016 to assess the efficacy of a reduced-dose rasburicase in patients with TLS. Materials and Methods: All the patients with TLS were given rasburicase (single dose of 1.5 mg) on day 1 of chemotherapy. Serum UA, potassium, creatinine, and calcium levels were monitored every 24 h. All the patients who did not achieve normalization of UA with one dose of rasburicase were given another 1.5 mg of rasburicase. Results: Out of 90 patients, 54 patients (60%) had normalization of UA levels after 1.5 mg of rasburicase and 16 (18%) patients required 3 mg of rasburicase for bringing down the UA level to normal. The low serum UA levels were maintained even on the 3rd day of rasburicase. Rasburicase was well tolerated, and there was no death due to TLS. Thirty-one patients (64%) had normalization in the serum creatinine levels after rasburicase. Conclusion: We conclude that a low dose of rasburicase (1.5 mg or 3 mg) is cost effective in reducing serum UA (especially for low-risk and intermediate-risk TLS) and the higher dose as recommended by the US FDA is required only for patients with high-risk TLS.
Depression among Women Diagnosed with Breast Cancer: A Study from North India
Authors: Thakur Monika , Gupta Bandna , Kumar Rohitash , Mishra Anand Kumar , Gupta Sameer , Kar Sujita Kumar 
Published: December 2019

Abstract
Introduction: Major depressive disorder is a major mental health problem and is the fourth most important cause of loss of disability-adjusted life years worldwide. Aim: The study aimed to assess the association of depression among women diagnosed with breast cancer. Methodology: A descriptive, cross-sectional study was done on 102 females diagnosed with breast cancer. Women were recruited using purposive sampling technique. Patients were evaluated on Mini International Neuropsychiatric Interview Version 6.0.0 to screen other psychiatric comorbidities. Hamilton depression 17-item, rating scale was used to measure severity of depression. Results: The prevalence of depression was 47.05% in women diagnosed with breast cancer. Majority of the patients (54.1%) had mild depression. Correlations of clinical and Sociodemographic variables with parameters of depression were not significant. Conclusions: Depression is commonly associated psychiatric morbidity in patients diagnosed with breast cancer. The severity of depression is independent of the sociodemographic and clinical variables of patients with breast cancer.
Neuroparenting: tussen apocalyps en utopie
Authors: Snoek Anke , Horstkötter Dorothee 
Published: December 2019

AbstractNeuroparenting: Between apocalypse and utopiaNeuroscience increasingly invades all domains of our lives, including the intimate realm of child raising and parenting. The current trend of neuroparenting, that is parenting advice based on neuroscientific research, fits this development. This article analyses this development from an ethical point of view. We will outline the current developments in the domain of neuroparenting with a special focus on the so-called ‘baby brain’ and ‘adolescent brain’. To discuss corresponding promises and perils, we do not only provide an overview of current studies developing ethical arguments, but we will also present several blind spots in that debate. We will conclude with some advice on how to integrate neuroscience findings in parenting practice in the most ethical way and point out limits that ought to be respected.
Onderwijs in het post-truth tijdperk
Authors: Lambrechts Wim 
Published: December 2019

Abstract

Education in the post-truth era: Reflections on the role of learning in sustainability and democracy

This paper revisits the field of (Higher) Education for Sustainable Development in a post-truth era. It reflects on the current debate regarding the role of education in sustainability from a Deweyan perspective. This approach leads towards a renewed interpretation of individual sustainability competences in societal context influenced by post-truth characteristics and super wicked problems. The Deweyan perspective with focus on personal flourishing and the role of education in democracy, provides guiding principles to frame individual sustainability competences in the current post-truth context, thereby highlighting the importance of critical inquiry. The paper recommends to revisit the connection between education and sustainability from a personal and societal perspective, thereby taking into account the current context of higher education, influenced by neoliberalism, economic efficiency and managerialism.
‘De overlevenden zullen de doden benijden’1
Authors: Duurland Tom 
Published: December 2019

Abstract

‘The living will envy the dead’: Medical responsibility in the face of a nuclear apocalypse, 1960-1989

During the 1980s, the heightening of tensions between nato and the Eastern Bloc motivated thousands of physicians to voice concerns about the medical consequences of a nuclear war. It seemed certain that such a conflict, extending to the major civilian centers and industrial areas of the protagonists, would see millions of casualties engulfing the health care systems. These gloomy predictions were coupled with the prevalent idea that nuclear war is immoral and physicians have a special responsibility to prevent it. Although contested by a majority of physicians, the medical movement against nuclear weapons found more support than ever before. In the Netherlands this is explained by (1) the intensity of the public debate, (2) the medicalization of the subject and (3) the compulsory registration of all physicians for Civil Defense plans. These factors motivated one third of all Dutch physicians to openly refuse cooperation with Civil Defense authorities. The article concludes that fear of an uncontrollable disaster put an emphasis on the ethics of consequentialism. This encouraged physicians to take political action and stress the importance of social responsibility in medicine.
Spatiotemporal variation of aerosol and potential long-range transport impact over the Tibetan Plateau, China
Authors: Zhu Jun , Xia Xiangao , Che Huizheng , Wang Jun , Cong Zhiyuan , Zhao Tianliang , Kang Shichang , Zhang Xuelei , Yu Xingna , Zhang Yanlin 
Published: December 2019

Abstract. The long-term temporal–spatial variations in the aerosol optical properties
over the Tibetan Plateau (TP) and the potential long-range transport from
surrounding areas to the TP were analyzed in this work, by using multiple years
of sun photometer measurements (CE318) at five stations in the TP, satellite
aerosol products from the Moderate Resolution Imaging Spectroradiometer (MODIS) and Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP), back-trajectory analysis from the Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) and model simulations from the Goddard Earth Observing System (GEOS)-Chem chemistry transport model. The results from the ground-based observations showed that the annual aerosol optical depth (AOD) at 440 nm at most TP sites increased in recent decades with trends of 0.001±0.003 yr−1 at Lhasa, 0.013±0.003 yr−1 at Mt_WLG, 0.002±0.002 yr−1 at NAM_CO and 0.000±0.002 yr−1 at QOMS_CAS. The increasing trend was also found for the aerosol extinction Ångström exponent (EAE) at most sites with the exception of the Mt_WLG site. Spatially, the AOD at 550 nm observed from MODIS showed negative trends at the northwest
edge close to the Taklimakan Desert and to the east of the Qaidam Basin and
slightly positive trends in most of the other areas of the TP. Different
aerosol types and sources contributed to a polluted day (with CE318 AOD at
440 nm > 0.4) at the five sites on the TP: dust was the dominant
aerosol type in Lhasa, Mt_WLG and Muztagh with sources in the Taklimakan Desert, but fine-aerosol pollution was dominant at NAM_CO and QOMS_CAS with transport from South Asia. A case of aerosol pollution at Lhasa, NAM_CO and QOMS_CAS during 28 April–3 May 2016 revealed that the
smoke aerosols from South Asia were lifted up to 10 km and transported to
the TP, while the dust from the Taklimakan Desert could climb the north
slope of the TP and then be transported to the central TP. The long-range
transport of aerosol thereby seriously impacted the aerosol loading over the TP.
The influence of the moisture content of raw materials on the structuring of the extrudates
Authors: Tsagareishvili Davit , Sesikashvili Otari , Dadunashvili Gia , Sakhanberidze Nugzari , Tsagareishvili Shalva 
Published: December 2019

The article presents the results of studies on the model systems of extrudates conducted with a view to determining the function of moisture during the process of forming the structure of starch pastes. There was studied the influence of the moisture content of raw materials on a starch gelatinization point. Studies showed that 15% moisture content in raw materials is sufficient for its constituent phase - starch gelatinization, as well as for the transition of the whole mass to a fluid-viscous state. Further increase in the moisture content is accompanied by a decrease in a gelatinization point. In order to study the influence of moisture on the formation of a porous structure of extrudates, we studied the relationship between the different-type starch pastes and the degree of its transparency and its embrittlement temperature. It has been found that during the process of thermal and mechanical impacts, there occurs the process of the formation of a structure of starch pastes, in particular, samples with the different moisture contents can have an amorphous or crystalline structure. There has been established the relationship between the moisture content of raw materials on the modulus of elasticity of starch pastes based on them. The modulus of elasticity of samples was determined one hour (cooling time to room temperature) and one week after obtaining the starch paste. The above studies showed that minimal physico-chemical and mechanical transformations occur in starch pastes, which are in an amorphous state, that is, in the conditions of a low moisture content. We have established that the moisture content of raw materials, on the one hand, ensures the transition of a high-dispersive phase to a fluid state, or implementing the ex process of extrusion, and on the other hand, influences on the formation of a porous structure in the extrudates.
Temporal Variability of Particulate Matter in Urban Area of Port Harcourt, Nigeria
Authors: Onuorah Christopher U. , Leton T. G. , Momoh O. L. Y. 
Published: December 2019

Particulate matter pollution poses serious health concern to public health in Nigeria especially at elevated concentration. Its size is very vital in determination of its long stay in the atmosphere as well as its deposition in human respiratory system. This study analyzes the temporal variation of particulate matter (PM10 and PM2.5) concentrations and its ratio in urban area of Port Harcourt. The study was carried out in Woji, area of Port Harcourt, Nigeria, from May to December 2018 using Aerocet 531 particulate monitor while meteorological variables were monitored via Misol wireless weather station mounted 10 m above the ground level. The highest particle pollution occurred in the month of December with an average daily PM2.5 concentration of 58.8 μgm-3 and PM10 concentration of 164.5 μgm-3, which exceeds WHO and USEPA daily threshold. These particle pollution exceedances recorded the dry season month of December was due to high atmospheric stability with dry dusty north east trade wind associated with harmattan. Also, Particulate matter concentration are usually lower during the weekends than weekdays with high PM level occurring at night from 8:00 PM to 9:00 AM in the morning with the peak at 8.00 AM. This shows that the weekdays experienced elevated PM level than weekend as a result of high industrial, commercial and traffic activities emitting particles within the weekdays. Also the average PM2.5/PM10 ratio for wet and dry season was 0.3 respectively. This shows that the town is town is predominated by coarse particle.