bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fairness and annuity divisors for notional defined contribution pension schemes
Authors: Boado-Penas María del Carmen , Haberman Steven , Naka Poontavika 
Published: October 2020

AbstractThe use of a gender-neutral annuity divisor introduces an intra-generational redistribution from short-lived towards long-lived individuals; this entails a transfer of wealth from males to females and from low socioeconomic groups to high socioeconomic groups. With some subpopulations consisting of females from low socioeconomic groups (or males from high groups), the net effect of the redistribution is unclear. The study aims to quantify the lifetime income redistribution of a generic NDC system using two types of divisor – the demographic and the economic – to compute the amount of an initial pension. With this in mind, the redistribution (actuarial fairness) among subpopulations is assessed through the ratio between the present value of expected pensions received and contributions paid. We find that all subgroups of women and men with high educational attainment benefit from the use of the unisex demographic divisor. This paper also shows that the value of the economic divisor depends markedly on population composition. When mortality differentials by gender and level of education are considered, economic divisors are mostly driven by the longevity effect corresponding to gender.
Hypercalcemia due to methadone-induced adrenal insufficiency in a case of oral cancer
Authors: Sharma Ankit , Subhash Mahajan Jitendra , Pandit Anuja , Bhan Swati , Bhatnagar Sushma 
Published: October 2020

AbstractA 31-year-old patient of post-surgical recurrent buccal carcinoma (post-chemo and radiotherapy) on multimodal analgesia with methadone, paracetamol and gabapentin presented to pain clinic with occasional bleeding from tumor area and incidental hypercalcemia. The hypercalcemia was attributed to adrenal insufficiency due to methadone, with no other obvious reasons identified for hypercalcemia or adrenal insufficiency. The patient was managed with the change of opioid, regular aseptic wound dressings and management of hypercalcemia with hydration, calcitonin and steroid therapy. Hypercalcemia in a cancer patient can have multiple other causes like hypercalcemia of malignancy and primary or secondary parathyroid carcinoma. A strong clinical suspicion and appropriate battery of tests may be required to arrive at the diagnosis. Prompt management, including identification and management of the primary pathology along with aggressive hydration with hormonal therapy, may prove to be life-saving.
Gender and Family Ties in Latin American Legislatures
Authors: Schwindt-Bayer Leslie A. , Vallejo Agustín , Cantú Francisco 
Published: October 2020

AbstractAre women disproportionately more likely than men to have family ties in politics? We study this question in Latin America, where legacies have been historically common, and we focus specifically on legislatures, where women's representation has increased dramatically in many countries. We hypothesize that, counter to conventional wisdom, women should be no more likely than men to have ties to political families. However, this may vary across legislatures with and without gender quotas. Our empirical analysis uses data from the Parliamentary Elites of Latin America survey. We find more gender similarities than differences in legislators’ patterns of family ties both today and over the past 20 years. We also find that women are more likely to have family ties than men in legislatures without gender quotas, whereas this difference disappears in legislatures with quotas.
Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
Authors: Juárez Yamila Raquel , Quiroga Sofía , Prochnik Andrés , Wald Miriam , Tellechea Mariana Lorena , Genaro Ana María , Burgueño Adriana Laura 
Published: October 2020

AbstractPrenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked with the development of obesity. The main goal of this study was to analyze the impact of the exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21. Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of sirtuin-1. When these animals were fed a HFD, we observed a rise in glucose and insulin levels and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1 beta. Although females proved to be more resilient to PS consequences, when they were fed a HFD, they showed significant metabolic impairment. In addition to the changes observed in males, females also presented an increase in body weight and adiposity and a rise in cholesterol levels.
Persistence of the Long‐Duration Daytime TEC Enhancements at Different Longitudinal Sectors During the August 2018 Geomagnetic Storm
Authors: Li Qiaoling , Huang Fuqing , Zhong Jiahao , Zhang Ruilong , Kuai Jiawei , Lei Jiuhou , Liu Libo , Ren Dexin , Ma Han , Yoshikawa Akimasa , Hu Lianhuan , Guo Jiapeng , Li Wenbo , Zhou Xu , Cui Jun 
Published: October 2020

AbstractIn this study, the ionospheric responses in the Asian‐Australian, American, and African sectors during the August 2018 geomagnetic storm were investigated based on the Beidou geostationary orbit (GEO) satellite and Massachusetts Institute of Technology (MIT) Madrigal total electron contents (TECs), combined with measurements from ionosondes, magnetometers, and Global Ultraviolet Imager (GUVI). The middle‐ and low‐latitude TECs were dominated by positive responses over the three longitudinal sectors during the storm on 26–29 August. It is unique that daytime TECs at the Asian‐Australian, American, and African sectors displayed large enhancements larger than 10 TEC units (TECu) on 27–29 August, during the recovery phase, when the ionosphere is usually dominated by plasma depletions due to the ionospheric disturbance dynamo and/or disturbed thermospheric compositions. The combination and competition of the disturbed vertical plasma drifts through the solar wind‐magnetosphere‐ionosphere (SW‐M‐I) coupling and disturbed neutral compositions contribute significantly to the daytime TEC responses at different longitudinal sectors on 26 August during the main and early recovery phases. The eastward equatorial electrojet and O/N2 during the recovery phase on 27–29 August are larger than the quiet reference, which suggest that the enhanced upward vertical plasma drifts combining with higher O/N2 make an important contribution on the daytime positive ionospheric storm during the recovery phase. The enhanced vertical plasma drifts could not be driven by the SW‐M‐I coupling or ionospheric disturbance dynamo associated with the geomagnetic storm. Further studies should be untaken to explore the dominant sources for the enhanced upward vertical drifts during the recovery phase.
Mechanisms of Exchange Flow in an Estuary With a Narrow, Deep Channel and Wide, Shallow Shoals
Authors: Geyer W. Rockwell , Ralston David K. , Chen Jia‐Lin 
Published: October 2020

AbstractDelaware Bay is a large estuary with a deep, relatively narrow channel and wide, shallow banks, providing a clear example of a “channel‐shoal” estuary. This numerical modeling study addresses the exchange flow in this channel‐shoal estuary, specifically to examine how the lateral geometry affects the strength and mechanisms of exchange flow. We find that the exchange flow is exclusively confined to the channel region during spring tides, when stratification is weak, and it broadens laterally over the shoals during the more stratified neap tides but still occupies a small fraction of the total width of the estuary. Exchange flow is relatively weak during spring tides, resulting from oscillatory shear dispersion in the channel augmented by weak Eulerian exchange flow. During neap tides, stratification and shear increase markedly, resulting in a strong Eulerian residual shear flow driven mainly by the along‐estuary density gradient, with a net exchange flow roughly 5 times that of the spring tide. During both spring and neap tides, lateral salinity gradients generated by differential advection at the edge of the channel drive a tidally oscillating cross‐channel flow, which strongly influences the stratification, along‐estuary salt balance, and momentum balance. The lateral flow also causes the phase variation in salinity that results in oscillatory shear dispersion and is an advective momentum source contributing to the residual circulation. Whereas the shoals make a negligible direct contribution to the exchange flow, they have an indirect influence due to the salinity gradients between the channel and the shoal.
Igneous or Mud Volcanism on Mars? The Case Study of Hephaestus Fossae
Authors: Dapremont Angela M. , Wray James J. 
Published: October 2020

AbstractHephaestus Fossae are a system of northwest trending troughs west of the Elysium Mons volcanic construct on Mars. Pitted cones present in the fossae region have previously been interpreted as both igneous and mud volcanism products based on morphometry and morphology observations. We take advantage of multiple orbital remote sensing datasets to assess the validity of these hypotheses. Newly examined visible and near‐infrared spectroscopy observations from the Compact Reconnaissance Imaging Spectrometer for Mars provide the strongest line of evidence for an igneous origin for fossae cones based on the presence of olivine signatures on cone rims. We report an expanded set of morphometric parameter values for 253 cones. Morphometry data from High Resolution Imaging Science Experiment and Context Camera (CTX) digital terrain models reveal that fossae cones appear most similar to terrestrial and putative Martian rootless cones but also exhibit similarities with mud volcanoes on Earth and Mars. Nine hundred and twenty‐six mapped cones in our study region exhibit a clustering pattern, as revealed by newly incorporated geospatial analysis, indicating that a nonrandom process controlled feature distribution and individual cones formed near preexisting cones. Cone‐fossae relationship constraints are revealed by CTX images, which show individual fossae cutting across preexisting cones. Fossae region cones lack associated flows that characterize mud volcanoes on Earth and Mars. The study region physiographic setting also does not support a sedimentary depocenter mud volcanism formation scenario. Our analysis of cones in the Hephaestus Fossae region adds to the studied diversity of pitted cones on Mars.
A general-purpose machine-learning force field for bulk and nanostructured phosphorus
Authors: Deringer Volker L. , Caro Miguel A. , Csányi Gábor 
Published: October 2020

AbstractElemental phosphorus is attracting growing interest across fundamental and applied fields of research. However, atomistic simulations of phosphorus have remained an outstanding challenge. Here, we show that a universally applicable force field for phosphorus can be created by machine learning (ML) from a suitably chosen ensemble of quantum-mechanical results. Our model is fitted to density-functional theory plus many-body dispersion (DFT + MBD) data; its accuracy is demonstrated for the exfoliation of black and violet phosphorus (yielding monolayers of “phosphorene” and “hittorfene”); its transferability is shown for the transition between the molecular and network liquid phases. An application to a phosphorene nanoribbon on an experimentally relevant length scale exemplifies the power of accurate and flexible ML-driven force fields for next-generation materials modelling. The methodology promises new insights into phosphorus as well as other structurally complex, e.g., layered solids that are relevant in diverse areas of chemistry, physics, and materials science.
Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
Authors: Wilson Brooke C. , Boehme Lena , Annibali Ambra , Hodgkinson Alan , Carroll Thomas S. , Oakey Rebecca J. , Seitan Vlad C. 
Published: October 2020

AbstractZbtb11 is a conserved transcription factor mutated in families with hereditary intellectual disability. Its precise molecular and cellular functions are currently unknown, precluding our understanding of the aetiology of this disease. Using a combination of functional genomics, genetic and biochemical approaches, here we show that Zbtb11 plays essential roles in maintaining the homeostasis of mitochondrial function. Mechanistically, we find Zbtb11 facilitates the recruitment of nuclear respiratory factor 2 (NRF-2) to its target promoters, activating a subset of nuclear genes with roles in the biogenesis of respiratory complex I and the mitoribosome. Genetic inactivation of Zbtb11 resulted in a severe complex I assembly defect, impaired mitochondrial respiration, mitochondrial depolarisation, and ultimately proliferation arrest and cell death. Experimental modelling of the pathogenic human mutations showed these have a destabilising effect on the protein, resulting in reduced Zbtb11 dosage, downregulation of its target genes, and impaired complex I biogenesis. Our study establishes Zbtb11 as an essential mitochondrial regulator, improves our understanding of the transcriptional mechanisms of nuclear control over mitochondria, and may help to understand the aetiology of Zbtb11-associated intellectual disability.
Multiple imputation for analysis of incomplete data in distributed health data networks
Authors: Chang Changgee , Deng Yi , Jiang Xiaoqian , Long Qi 
Published: October 2020

AbstractDistributed health data networks (DHDNs) leverage data from multiple sources or sites such as electronic health records (EHRs) from multiple healthcare systems and have drawn increasing interests in recent years, as they do not require sharing of subject-level data and hence lower the hurdles for collaboration between institutions considerably. However, DHDNs face a number of challenges in data analysis, particularly in the presence of missing data. The current state-of-the-art methods for handling incomplete data require pooling data into a central repository before analysis, which is not feasible in DHDNs. In this paper, we address the missing data problem in distributed environments such as DHDNs that has not been investigated previously. We develop communication-efficient distributed multiple imputation methods for incomplete data that are horizontally partitioned. Since subject-level data are not shared or transferred outside of each site in the proposed methods, they enhance protection of patient privacy and have the potential to strengthen public trust in analysis of sensitive health data. We investigate, through extensive simulation studies, the performance of these methods. Our methods are applied to the analysis of an acute stroke dataset collected from multiple hospitals, mimicking a DHDN where health data are horizontally partitioned across hospitals and subject-level data cannot be shared or sent to a central data repository.
Topological metastability supported by thermal fluctuation upon formation of chiral soliton lattice in $$\hbox {CrNb}_3\hbox {S}_6$$
Authors: Honda T. , Yamasaki Y. , Nakao H. , Murakami Y. , Ogura T. , Kousaka Y. , Akimitsu J. 
Published: October 2020

AbstractTopological magnetic structure possesses topological stability characteristics that make it robust against disturbances which are a big advantage for data processing or storage devices of spintronics; nonetheless, such characteristics have been rarely clarified. This paper focused on the formation of chiral soliton lattice (CSL), a one-dimensional topological magnetic structure, and provides a discussion of its topological stability and influence of thermal fluctuation. Herein, CSL responses against change of temperature and applied magnetic field were investigated via small-angle resonant soft X-ray scattering in chromium niobium sulfide ($$\hbox {CrNb}_3\hbox {S}_6$$

CrNb
3

S
6

). CSL transformation relative to the applied magnetic field demonstrated a clear agreement with the theoretical prediction of the sine-Gordon model. Further, there were apparent differences in the process of chiral soliton creation and annihilation, discussed from the viewpoint of competing between thermal fluctuation and the topological metastability.
Unravelling the gut bacteriome of Ips (Coleoptera: Curculionidae: Scolytinae): identifying core bacterial assemblage and their ecological relevance
Authors: Chakraborty Amrita , Ashraf Muhammad Zubair , Modlinger Roman , Synek Jiří , Schlyter Fredrik , Roy Amit 
Published: October 2020

AbstractBark beetles often serve as forest damaging agents, causing landscape-level mortality. Understanding the biology and ecology of beetles are important for both, gathering knowledge about important forest insects and forest protection. Knowledge about the bark beetle gut-associated bacteria is one of the crucial yet surprisingly neglected areas of research with European tree-killing bark beetles. Hence, in this study, we survey the gut bacteriome from five Ips and one non-Ips bark beetles from Scolytinae. Results reveal 69 core bacterial genera among five Ips beetles that may perform conserved functions within the bark beetle holobiont. The most abundant bacterial genera from different bark beetle gut include Erwinia, Sodalis, Serratia, Tyzzerella, Raoultella, Rahnella, Wolbachia, Spiroplasma, Vibrio, and Pseudoxanthomonas. Notable differences in gut-associated bacterial community richness and diversity among the beetle species are observed. Furthermore, the impact of sampling location on the overall bark beetle gut bacterial community assemblage is also documented, which warrants further investigations. Nevertheless, our data expanded the current knowledge about core gut bacterial communities in Ips bark beetles and their putative function such as cellulose degradation, nitrogen fixation, detoxification of defensive plant compounds, and inhibition of pathogens, which could serve as a basis for further metatranscriptomics and metaproteomics investigations.
Ex-vivo mechanical sealing properties and toxicity of a bioadhesive patch as sealing system for fetal membrane iatrogenic defects
Authors: Micheletti Talita , Eixarch Elisenda , Berdun Sergio , Febas Germán , Mazza Edoardo , Borrós Salvador , Gratacos Eduard 
Published: October 2020

AbstractPreterm prelabor rupture of membranes (PPROM) is the most frequent complication of fetal surgery. Strategies to seal the membrane defect created by fetoscopy aiming to reduce the occurrence of PPROM have been attempted with little success. The objective of this study was to evaluate the ex-vivo mechanical sealing properties and toxicity of four different bioadhesives integrated in semi-rigid patches for fetal membranes. We performed and ex-vivo study using term human fetal membranes to compare the four integrated patches composed of silicone or silicone-polyurethane combined with dopaminated-hyaluronic acid or hydroxypropyl methylcellulose (HPMC). For mechanical sealing properties, membranes were mounted in a multiaxial inflation device with saline, perforated and sealed with the 4 combinations. We measured bursting pressure and maximum pressure free of leakage (n = 8). For toxicity, an organ culture of membranes sealed with the patches was used to measure pyknotic index (PI) and lactate dehydrogenase (LDH) concentration (n = 5). All bioadhesives achieved appropriate bursting pressures, but only HPMC forms achieved high maximum pressures free of leakage. Concerning toxicity, bioadhesives showed low PI and LDH levels, suggesting no cell toxicity. We conclude that a semi-rigid patch coated with HPMC achieved ex-vivo sealing of iatrogenic defects in fetal membranes with no signs of cell toxicity. These results warrant further research addressing long-term adhesiveness and feasibility as a sealing system for fetoscopy.
Dissemination of Verona Integron-encoded Metallo-β-lactamase among clinical and environmental Enterobacteriaceae isolates in Ontario, Canada
Authors: Kohler Philipp , Tijet Nathalie , Kim Hyunjin C. , Johnstone Jennie , Edge Tom , Patel Samir N. , Seah Christine , Willey Barbara , Coleman Brenda , Green Karen , Armstrong Irene , Katz Kevin , Muller Matthew P. , Powis Jeff , Poutanen Susan M. , Richardson David , Sarabia Alicia , Simor Andrew , McGeer Allison , Melano Roberto G. ,   The Toronto Invasive Bacterial Diseases Network (TIBDN), Plevneshi Agron , Rudnick Wallis , Jamieson Frances , Yaffe Barbara , Matukas Larissa , Downey James , Gold Wayne , Walmsley Sharon , Baqi Mahin , Vearncombe Mary , Belhaj Abdelbaset , Kitai Ian , Chen Danny , de Villa Eileen , Dick Hani , Farshait Nataly , Lee King S. , Krajden Sigmund , Lingley Michael , Lovinsky Reena , Rose David , O’Grady Sharon , Opavsky Anne , Ostrowska Krystyna , Petrich Astrid , Richardson Susan , Rau Neil , Ricciuto Daniel , Sales Valerie , Yamamura Deborah 
Published: October 2020

AbstractSurveillance data from Southern Ontario show that a majority of Verona Integron-encoded Metallo-β-lactamase (VIM)-producing Enterobacteriaceae are locally acquired. To better understand the local epidemiology, we analysed clinical and environmental blaVIM-positive Enterobacteriaceae from the area. Clinical samples were collected within the Toronto Invasive Bacterial Diseases Network (2010–2016); environmental water samples were collected in 2015. We gathered patient information on place of residence and hospital admissions prior to the diagnosis. Patients with and without plausible source of acquisition were compared regarding risk exposures. Microbiological isolates underwent whole-genome sequencing (WGS); blaVIM carrying plasmids were characterized. We identified 15 patients, thereof 11 with blaVIM-1-positive Enterobacter hormaechei within two genetic clusters based on WGS. Whereas no obvious epidemiologic link was identified among cluster I patients, those in cluster II were connected to a hospital outbreak. Except for patients with probable acquisition abroad, we did not identify any further risk exposures. Two blaVIM-1-positive E. hormaechei from environmental waters matched with the clinical clusters; plasmid sequencing suggested a common ancestor plasmid for the two clusters. These data show that both clonal spread and horizontal gene transfer are drivers of the dissemination of blaVIM-1-carrying Enterobacter hormaechei in hospitals and the aquatic environment in Southern Ontario, Canada.
Intuitive decision-making promotes rewarding prosocial others independent of the personality trait Honesty-Humility
Authors: Nockur Laila , Pfattheicher Stefan 
Published: October 2020

AbstractAlthough past research has convincingly shown that rewarding prosocial individuals helps to establish high levels of cooperation, research investigating factors that promote rewarding others has been surprisingly rare. The present research addresses this gap and examines two factors that were shown in past research to play a role in prosocial behaviour. In a well-powered study (totalN = 1003), we tested the impact of (a) a basic prosocial personality trait (the Honesty-Humility dimension from the HEXACO personality model) and (b) intuitive decision-making, as well as (c) their interaction, in rewarding prosocial individuals. We found that (1) intuition promotes rewarding prosocial others; (2) Honesty-Humility was not significantly related to rewarding prosocial others; and (3) that Honesty-Humility did not significantly moderate the effect of intuition on reward. Implications for the understanding of reciprocating others’ prosocial behaviour are discussed.