bluuebunny/crossref_metadata_2025_split huggingface dataset:
Child catastrophizing about parent chronic pain: A potential child vulnerability factor
Authors: Higgins Kristen S. , Chambers Christine T. , Rosen Natalie O. , Sherry Simon , Mohammadi Somayyeh , Lynch Mary E. , Campbell‐Yeo Marsha , Clark Alexander J. 
Published: March 2020

ObjectiveRobust evidence suggests children’s catastrophizing about their own pain is a risk factor for poor child pain‐related outcomes. In children of parents with chronic pain, child catastrophizing about their parents’ pain might be a unique predictor of child pain‐related outcomes given their increased exposure to parental chronic pain and disability. The objective of this study was to examine associations between child and parent catastrophizing about their own and each other’s pain and child and parent pain‐related outcomes.MethodsSeventy‐two parents with chronic pain and their children (ages 8–15) completed questionnaires assessing their trait catastrophizing about their own and each other’s pain, their own pain, and the child’s internalizing symptoms. Children completed the cold pressor task (CPT) in the presence of their parent. Parents and children rated children’s worst pain intensity and their own anxiety during the task. Analyses were guided by the Actor‐Partner Interdependence Model.ResultsGreater child catastrophizing about parent pain was associated with children’s and parents’ increased catastrophizing about their own pain. Child catastrophizing about parent pain was associated with greater child‐ and parent‐reported child internalizing symptoms and greater CPT pain intensity for the child, but not parent/child usual pain or CPT anxiety, over and above the influence of parent and child catastrophizing about their own pain.ConclusionsChild catastrophizing about parent pain is a potential vulnerability factor associated with poor pain‐related outcomes in children of parents with chronic pain that should be considered in future research and clinical settings.
Statement of contribution

What is already known on this subject?

Higher rates of pain and internalizing symptoms are observed in offspring of parents with vs. without chronic pain.

Greater child and parent pain catastrophizing are associated with poorer pain‐related outcomes in children.

Child catastrophizing about parent chronic pain and its association with child outcomes has not been examined.

What does this study add?

Greater child catastrophizing about parent chronic pain is associated with greater child internalizing and CPT pain.

These effects were seen beyond the association of child and parent catastrophizing about their own pain.
Endothelium‐targeted overexpression of Krüppel‐like factor 11 protects the blood‐brain barrier function after ischemic brain injury
Authors: Zhang Xuejing , Tang Xuelian , Ma Feifei , Fan Yanbo , Sun Ping , Zhu Tianqing , Zhang Jifeng , Hamblin Milton H. , Chen Y. Eugene , Yin Ke‐Jie 
Published: March 2020

AbstractMicrovascular endothelial cell (EC) injury and the subsequent blood‐brain barrier (BBB) breakdown are frequently seen in many neurological disorders, including stroke. We have previously documented that peroxisome proliferator‐activated receptor gamma (PPARγ)‐mediated cerebral protection during ischemic insults needs Krüppel‐like factor 11 (KLF11) as a critical coactivator. However, the role of endothelial KLF11 in cerebrovascular function and stroke outcome is unclear. This study is aimed at investigating the regulatory role of endothelial KLF11 in BBB preservation and neurovascular protection after ischemic stroke. EC‐targeted overexpression of KLF11 significantly mitigated BBB leakage in ischemic brains, evidenced by significantly reduced extravasation of BBB tracers and infiltration of peripheral immune cells, and less brain water content. Endothelial cell‐selective KLF11 transgenic (EC‐KLF11 Tg) mice also exhibited smaller brain infarct and improved neurological function in response to ischemic insults. Furthermore, EC‐targeted transgenic overexpression of KLF11 preserved cerebral tight junction (TJ) levels and attenuated the expression of pro‐inflammatory factors in mice after ischemic stroke. Mechanistically, we demonstrated that KLF11 directly binds to the promoter of major endothelial TJ proteins including occludin and ZO‐1 to promote their activities. Our data indicate that KLF11 functions at the EC level to preserve BBB structural and functional integrity, and therefore, confers brain protection in ischemic stroke. KLF11 may be a novel therapeutic target for the treatment of ischemic stroke and other neurological conditions involving BBB breakdown and neuroinflammation.
Assessing skeletal muscle radiodensity by computed tomography: An integrative review of the applied methodologies
Authors: Poltronieri Taiara Scopel , de Paula Nathália Silva , Chaves Gabriela Villaça 
Published: March 2020

AbstractLow‐radiodensity skeletal muscle has been related to the degree of muscle fat infiltration and seems to be associated with worse outcomes. The aim of this study was to summarize the methodologies used to appraise skeletal muscle radiodensity by computed tomography, to describe the terms used in the literature to define muscle radiodensity and to give recommendations for its measurement standardization. An integrative bibliographic review in four databases included studies published until August 2019 in Portuguese, English or Spanish and performed in humans, adults and/or the elderly, of both sex, which investigated skeletal muscle radiodensity through computed tomography (CT) of the region between the third and fifth lumbar vertebrae and evaluated at least two muscular groups. One hundred and seventeen studies were selected. We observed a trend towards selecting all abdominal region muscle. A significant methodological variation in terms of contrast use, selection of skeletal muscle areas, radiodensity ranges delimitation and their cut‐off points, as well as the terminologies used, was also found. The methodological differences detected are probably due to the lack of more precise information about the correlation between skeletal muscle radiodensity by CT and its molecular composition, among others. Therefore, until the gaps are addressed in future studies, authors should avoid arbitrary approaches when reporting skeletal muscle radiodensity, especially when it comes to prognosis inference. Studies using both CT and direct methods of muscle composition evaluation are encouraged, to enable the definition and validation of the best approach to classify fat‐infiltrated muscle tissue, which will favour the nomenclature uniformization.
Alcohol‐related male mortality in the context of changing alcohol control policy in Lithuania 2000–2017
Authors: Stumbrys Daumantas , Telksnys Tadas , Jasilionis Domantas , Liutkutė Gumarov Vaida , Galkus Lukas , Goštautaitė Midttun Nijolė , Štelemėkas Mindaugas 
Published: March 2020

AbstractIntroduction and AimsOver the recent decades, Lithuania has reported very high alcohol‐related harm and mortality indicators when compared to other countries. This, among other reasons, led to an adoption of comprehensive evidence‐based alcohol control policy measures back in 2007 and 2016. The aim of this study is to examine alcohol‐related male mortality in the context of changing alcohol control policies over the period 2000–2017.Design and MethodsThe life table decomposition method was applied to estimate to what extent the age groups and causes of death are responsible for changes in male life expectancy in the period 2000–2017. Furthermore, a time series intervention model was used to study the impact of alcohol control measures on alcohol‐related mortality. A seasonal autoregressive integrated moving average model was fitted.ResultsMale life expectancy increased by 6.23 years in the period 2007–2017, mainly due to a decrease in mortality from external causes of death (2.12 years), cardiovascular diseases (1.84 years) and alcohol‐related disorders (0.86 years). Reduced male mortality in the 30–64 years age group also contributed to a large increase in male life expectancy during the same period.Discussion and ConclusionsThe greatest positive effect of reduced alcohol‐related mortality to male life expectancy was observed during the period 2007–2009. It overlaps with the start of implementation of the comprehensive alcohol control measures. However, further research on the impact of different alcohol policy interventions on various outcomes is needed.
Comparing the mechanical properties of a self‐expandable metallic stent for colorectal obstruction: Proposed measurement method of axial force using a new measurement machine
Authors: Sasaki Takashi , Ishibashi Rei , Yoshida Shuntaro , Fujisawa Toshio , Shinagawa Hiroki , Gon Chimyon , Nakai Yousuke , Sasahira Naoki , Saida Yoshihisa , Isayama Hiroyuki 
Published: March 2020

ObjectivesColorectal stenting is widely performed using self‐expandable metallic stents (SEMSs), but the mechanical properties have not been evaluated. Therefore, we conducted an in vitro study to evaluate the mechanical properties of colorectal SEMSs.MethodsEighteen individual types and sizes of uncovered SEMSs were evaluated for their mechanical properties. Radial force was measured using a measurement machine. Axial force (AF) was measured by two methods: a conventional manual method and a new method using a measurement machine. The correlation of these two methods was evaluated. We also proposed an “AF zero border” that was defined as the angle at which the torque force disappeared.ResultsRadial force versus diameter curves and AF versus angle curves were influenced by the structure and the size of each stent. There was excellent correlation of AFs measured by the new and conventional manual method (y = 21.434x, R = 0.881, P < 0.0001). Colorectal SEMSs could be categorized into five subgroups according to the mechanical properties. Most hook‐wired SEMSs had the AF of zero border.ConclusionsThis is the first report to evaluate the mechanical properties of colorectal SEMSs, and these data may provide useful information for the clinical use and development of colorectal SEMS. Furthermore, the new measurement machine might standardize the measuring method of AF.
Chemical cues from competitors change the oviposition preference of Drosophila suzukii
Authors: Kidera Hiroaki , Takahashi Kazuo H. 
Published: March 2020

AbstractAlthough Drosophila suzukii Matsumura (Diptera: Drosophilidae) infests fresh and ripening fruits, it is attracted to fermented fruits as well. Because fermented fruits attract other flies too, if D. suzukii utilizes fermented fruits as oviposition substrates, competition can be more intense on them. To avoid such competition, D. suzukii may change oviposition preference when particular species of competitor flies are present, but the effect of odor cues associated with competitors on the oviposition preference of D. suzukii is still unknown. To examine such an effect, we investigated the oviposition preference of D. suzukii in the presence of four competitor fly species – Drosophila melanogaster Meigen, Drosophila lutescens Malloch, Drosophila rufa Kikkawa & Peng, and Drosophila auraria Peng – and D. suzukii itself. We prepared artificial substrates with yeast treatment (Y+: yeast supplementation, Y−: control) and competitor fly treatment (F+: pre‐inoculated with competitor fly odor, F−: control), and performed two‐choice experiments using the substrates with various Y and F treatments. Our results showed that D. suzukii oviposited more eggs on Y+ substrates than on Y− substrates when no competitor flies were present and the presence of competitor flies influenced D. suzukii’s oviposition preference for yeast‐supplemented substrates and its effect changed depending on the competitor fly species. If the presence of competitors around fallen fruits on the ground suppresses D. suzukii’s oviposition on the fallen fruits and facilitates the oviposition on non‐fermenting substrates in nature, it may drive D. suzukii to use ripening fruits on the tree. Such selective pressure may facilitate the evolution of morphological traits such as a serrated ovipositor in D. suzukii.
Conservatism and stability of the symbiotic system of the invasive alien treehopper Stictocephala bisonia (Hemiptera, Cicadomorpha, Membracidae)
Authors: Szklarzewicz Teresa , Świerczewski Dariusz , Stroiński Adam , Michalik Anna 
Published: March 2020

1. Nutritional symbiosis between insects and microorganisms (bacteria and/or yeast‐like symbionts) that provide amino acids and vitamins which are lacking in the diet of host insects is widespread in nature. Auchenorrhyncha are usually host to two ancient bacterial symbionts – bacterium Sulcia (Bacteroidetes) and a betaproteobacterium – which, in some groups, were lost or replaced by other bacteria.2. The aim of this research was to: (i) identify the symbiotic microorganisms associated with the invasive treehopper Stictocephala bisonia; (ii) describe their localisation as well as the mode of inheritance; and (iii) address the issue of whether individuals of S. bisonia, living in different areas and feeding on various plants, possess identical, similar or perhaps different symbiotic microbial systems.3. Individuals of S. bisonia collected in their native range in North America (U.S.A.) and in 11 localities in Europe were investigated using molecular, histological and ultrastructural methods.4. The results indicate that all the examined specimens are characterised by the same conservative symbiotic system. All of them are host to only two types of bacterial symbiont: Sulcia and the betaproteobacteria belonging to the Nasuia lineage. No other symbionts in any of 36 individuals examined were detected.5. Both symbionts are localised in a common bacteriome and are transovarially transmitted between generations.
A randomized, double‐blind, single‐dose, three‐arm, parallel group study to determine pharmacokinetic similarity of ABP 959 and eculizumab (Soliris®) in healthy male subjects
Authors: Chow Vincent , Pan Jean , Chien David , Mytych Daniel T. , Hanes Vladimir 
Published: March 2020

AbstractObjectivesABP 959 is a proposed biosimilar to eculizumab, a monoclonal antibody targeting the human C5 complement protein. The objective of this randomized, double‐blind, three‐arm, study was to demonstrate pharmacokinetic (PK) and pharmacodynamic (PD) similarity of ABP 959 relative to the eculizumab reference product (RP) in healthy adult male subjects.MethodsEligible subjects aged 18‐45 years were randomized to receive a 300‐mg IV infusion of ABP 959, or FDA‐licensed eculizumab (eculizumab US), or EU‐authorized eculizumab (eculizumab EU). Primary PK endpoint was area under the total serum concentration‐time curve from 0 to infinity (AUC0−∞); primary PD endpoint was area between the effect curve (ABEC) of CH50‐time data.ResultsThe geometric mean of PK and PD parameters were similar between ABP 959 versus eculizumab US and eculizumab EU; PK and PD similarity was established based on 90% confidence intervals of the geometric mean ratio being within prespecified equivalence margin of 0.8 and 1.25. The incidence of treatment‐emergent adverse events was similar across groups. The incidence of binding anti‐drug antibodies was similar across treatments; no subjects developed neutralizing antibodies.ConclusionsThis study demonstrated PK and PD similarity of ABP 959 to eculizumab RP; safety and immunogenicity profiles were also similar.
Monogenic cerebral small‐vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology
Authors: Mancuso M. , Arnold M. , Bersano A. , Burlina A. , Chabriat H. , Debette S. , Enzinger C. , Federico A. , Filla A. , Finsterer J. , Hunt D. , Lesnik Oberstein S. , Tournier‐Lasserve E. , Markus H. S. 
Published: March 2020

Background and purposeGuidelines on monogenic cerebral small‐vessel disease (cSVD) diagnosis and management are lacking. Endorsed by the Stroke and Neurogenetics Panels of the European Academy of Neurology, a group of experts has provided recommendations on selected monogenic cSVDs, i.e. cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), autosomal dominant High Temperature Requirement A Serine Peptidase 1 (HTRA1), cathepsin‐A‐related arteriopathy with strokes and leukoencephalopathy (CARASAL), pontine autosomal dominant microangiopathy and leukoencephalopathy (PADMAL), Fabry disease, mitochondrial encephalopathy, lactic acidosis and stroke‐like episodes (MELAS) and type IV collagen (COL4)A1/2.MethodsWe followed the Delphi methodology to provide recommendations on several unanswered questions related to monogenic cSVD, including genetic testing, clinical and neuroradiological diagnosis, and management.ResultsWe have proposed ‘red‐flag’ features suggestive of a monogenic disease. General principles applying to the management of all cSVDs and specific recommendations for the individual forms of monogenic cSVD were agreed by consensus.ConclusionsThe results provide a framework for clinicians involved in the diagnosis and management of monogenic cSVD. Further multicentre observational and treatment studies are still needed to increase the level of evidence supporting our recommendations.
Age‐related differences in blood pressure, ultrasound‐derived arterial diameters and arterial wall stiffness parameters in horses
Authors: Vera Lisse , Van Steenkiste Glenn , Decloedt Annelies , Chiers Koen , van Loon Gunther 
Published: March 2020

AbstractBackgroundArterial rupture mainly affects older horses. The reason why older horses are more prone to arterial rupture and which underlying vascular changes predispose older horses to aortic rupture is still unclear.ObjectivesTo investigate the effect of ageing on the equine arterial wall and blood pressure.Study designCohort study.MethodsNon‐invasive blood pressure measurement using a tail cuff and vascular ultrasound from aorta, common carotid artery and external iliac artery was performed in 50 healthy young (3‐7 years) and 50 healthy old Warmblood horses (>18 years). Arterial diameters and cross‐sectional areas, and arterial wall thickness were measured offline. Regional arterial wall stiffness of the aorta and common carotid artery were assessed using pulse wave velocity, while lumen area/diameter change, strain, compliance and distensibility were calculated to assess local arterial wall stiffness.ResultsNo difference in blood pressure was found between old and young horses. All arterial dimensions and intima‐media thickness of the common carotid artery were significantly larger in old horses. A significantly higher local arterial wall stiffness was found for the aorta and the caudal common carotid artery in older horses. For the external iliac artery, no significant differences in arterial wall stiffness were found. Both aortic and carotid pulse wave velocities were higher in older horses compared with younger horses.Main limitationsBlood pressure was measured non‐invasively.ConclusionsIn horses, arteries stiffen with age, in combination with luminal enlargement and arterial wall thickening. This might, at least partially, explain the increased incidence of arterial rupture in older horses.
The role of sand lances (Ammodytes sp.) in the Northwest Atlantic Ecosystem: A synthesis of current knowledge with implications for conservation and management
Authors: Staudinger Michelle D. , Goyert Holly , Suca Justin J. , Coleman Kaycee , Welch Linda , Llopiz Joel K. , Wiley David , Altman Irit , Applegate Andew , Auster Peter , Baumann Hannes , Beaty Julia , Boelke Deirdre , Kaufman Les , Loring Pam , Moxley Jerry , Paton Suzanne , Powers Kevin , Richardson David , Robbins Jooke , Runge Jeffrey , Smith Brian , Spiegel Caleb , Steinmetz Halley 
Published: March 2020

AbstractThe American sand lance (Ammodytes americanus, Ammodytidae) and the Northern sand lance (A. dubius, Ammodytidae) are small forage fishes that play an important functional role in the Northwest Atlantic Ocean (NWA). The NWA is a highly dynamic ecosystem currently facing increased risks from climate change, fishing and energy development. We need a better understanding of the biology, population dynamics and ecosystem role of Ammodytes to inform relevant management, climate adaptation and conservation efforts. To meet this need, we synthesized available data on the (a) life history, behaviour and distribution; (b) trophic ecology; (c) threats and vulnerabilities; and (d) ecosystem services role of Ammodytes in the NWA. Overall, 72 regional predators including 45 species of fishes, two squids, 16 seabirds and nine marine mammals were found to consume Ammodytes. Priority research needs identified during this effort include basic information on the patterns and drivers in abundance and distribution of Ammodytes, improved assessments of reproductive biology schedules and investigations of regional sensitivity and resilience to climate change, fishing and habitat disturbance. Food web studies are also needed to evaluate trophic linkages and to assess the consequences of inconsistent zooplankton prey and predator fields on energy flow within the NWA ecosystem. Synthesis results represent the first comprehensive assessment of Ammodytes in the NWA and are intended to inform new research and support regional ecosystem‐based management approaches.
Erythropoietin induces miRNA‐210 by JAK2/STAT5 signaling in PBMCs of End‐stage Renal Disease patients
Authors: Felaco Paolo , Felaco Mario , Franceschelli Sara , Ferrone Alessio , Gatta Daniela M. P. , Speranza Lorenza , Patruno Antonia , De Lutiis Maria A. , Ballerini Patrizia , Sirolli Vittorio , Grilli Alfredo , Bonomini Mario , Pesce Mirko 
Published: March 2020

Anemia of chronic kidney disease is associated with blunted response/resistance to erythropoietin‐stimulating agents (ESAs) in hemodialysis (HD) patients. Several molecules have been successfully associated with ESA responsiveness; however, none of them is now considered a valid therapeutic biomarker of erythropoietin resistance in these patients. We performed an evaluation of the level of specific plasma circulating miRNAs in blood samples of HD patients, in relation to ESA treatment, with a follow‐up of 1 year (T0–T3). We found significantly lower circulating levels of all miRNAs analyzed at baseline (T0) in HD patients vs. healthy control (HC). The plasmatic levels of miRNA‐210 resulted significantly and negatively associated with Erythropoietin Resistance Index (ERI), and the variance of ΔmiRNA‐210 (miRNA‐210T3 minus miRNA‐210T0) explained significant percentage of ΔERI (ERIT3 minus ERIT0) variance. The receiver operating characteristic analysis at T0 showed that the plasmatic level of miRNA‐210 could distinguish HD patients with positive or negative trend in ERI at T3. In vitro, recombinant human erythropoietin (EPO) induced significant release of miRNA‐210 from cultured peripheral blood mononuclear cells, through the activation of Janus kinase 2 (JAK2)/ signal transducer and activator of transcription 5 (STAT5) signaling, but not by the activation of the MAPK protein 38α and extracellular signal‐regulated kinase ½. Accordingly, HD patients with negative ΔERI showed higher level of phosphor‐Janus kinase 2 and nuclear translocation of phosphor‐signal transducer and activator of transcription 5. vs. patients with positive ΔERI or HC. Our data highlighted that chronic HD significantly reduces the circulating level of the miRNAs evaluated; within the targets analyzed, the miRNA‐210 could be considered as a prognostic indicator of ESA responsiveness and index for anemia management.