bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atmospheric Radiation Measurement (ARM) Aerosol Observing Systems (AOS) for Surface-Based In Situ Atmospheric Aerosol and Trace Gas Measurements
Authors: Uin Janek , Aiken Allison C. , Dubey Manvendra K. , Kuang Chongai , Pekour Mikhail , Salwen Cynthia , Sedlacek Arthur J. , Senum Gunnar , Smith Scott , Wang Jian , Watson Thomas B. , Springston Stephen R. 
Published: November 2019

AbstractAerosols alter Earth’s radiative budget both directly and indirectly through interaction with clouds. Continuous observations are required to reduce the uncertainties in climate models associated with atmospheric processing and the interactions between aerosols and clouds. Field observations of aerosols are a central component of the Atmospheric Radiation Measurement (ARM) Facility’s global measurements. The ARM mission goal is to “provide the climate research community with strategically located in situ and remote sensing observatories designed to improve the understanding and representation, in climate and earth system models, of clouds and aerosols as well as their interactions and coupling with the Earth’s surface.” Since 1996, ARM has met this goal by operating Aerosol Observing Systems (AOS) for in situ measurement of aerosols. Currently the five ARM AOSs are the most comprehensive field deployable aerosol systems in the United States. The AOS suite includes seven measurement classes: number concentration, size distribution, chemical composition, radiative and optical properties, hygroscopicity, trace gases, and supporting meteorological conditions. AOSs are designed as standardized measurement platforms to enable intercomparison across the ARM Facility for regional process studies within a global context. The instrumentation and measurement capabilities of the ARM AOSs, along with a history of their design and field deployments are presented here.
Hindcasting the First Tornado Forecast in Europe: 25 June 1967
Authors: Antonescu Bogdan , Púçik Tomáš , Schultz David M. 
Published: November 2019

Abstract
The tornado outbreak of 24–25 June 1967 was the most damaging in the history of western Europe, producing 7 F2–F5 tornadoes, 232 injuries, and 15 fatalities across France, Belgium, and the Netherlands. Following tornadoes in France on 24 June, the Royal Netherlands Meteorological Institute (KNMI) issued a tornado forecast for 25 June, which became the first ever—and first verified—tornado forecast in Europe. Fifty-two years later, tornadoes are still not usually forecast by most European national meteorological services, and a pan-European counterpart to the NOAA/NWS/Storm Prediction Center (SPC) does not exist to provide convective outlook guidance; yet, tornadoes remain an extant threat. This article asks, “What would a modern-day forecast of the 24–25 June 1967 outbreak look like?” To answer this question, a model simulation of the event is used in three ways: 20-km grid-spacing output to produce a SPC-style convective outlook provided by the European Storm Forecast Experiment (ESTOFEX), 800-m grid-spacing output to analyze simulated reflectivity and surface winds in a nowcasting analog, and 800-m grid-spacing output to produce storm-total footprints of updraft helicity maxima to compare to observed tornado tracks. The model simulates a large supercell on 24 June and weaker embedded mesocyclones on 25 June forming along a stationary front, allowing the ESTOFEX outlooks to correctly identify the threat. Updraft helicity footprints indicate multiple mesocyclones on both days within 40–50 km and 3–4 h of observed tornado tracks, demonstrating the ability to hindcast a large European tornado outbreak.
Office-Based Steroid Injections for Idiopathic Subglottic Stenosis: Patient-Reported Outcomes, Effect on Stenosis, and Side Effects
Authors: Hoffman Matthew R. , Francis David O. , Mai Johnny P. , Dailey Seth H. 
Published: November 2019

Objective: Office-based steroid injection has shown promise for idiopathic subglottic stenosis (iSGS). It is important to understand safety and patient-lived experience. We report patient experience related to airway restriction, voice, and side effects. Methods: Sixteen patients (51 ± 14 years) with mild-moderate (20-50%) stenosis undergoing office-based transnasal steroid injections were included; fourteen had prior operations. Patients typically underwent three injections, 1 month apart, followed by transnasal tracheoscopy 1 month later to evaluate outcome; number of injections can vary based on disease severity and response. Outcomes were Dyspnea Index (DI), Modified Medical Research Council (MMRC) dyspnea scale, voice handicap index-10 (VHI-10), and degree of stenosis (estimated from procedural video). At each visit, patients were queried about post-injection airway restriction and side effects. Paired t-tests compared values at baseline versus follow-up tracheoscopy. Results: DI decreased ( t = 3.938, P = 0.0013), as did MMRC ( t = 2.179, P = 0.0457). There was no change in VHI-10 ( t = 1.354; P = 0.1957) scores. Airway stenosis decreased ( t = 4.331; P = 0.0006); this was not correlated with change in DI ( r = 0.267, P = 0.318). Side effects included airway restriction lasting <48 hours (n = 5), cough (n = 3), and nasal pain (n = 2). Conclusion: Steroid injections improved upper airway symptoms. Side effects were mild and transient. Improvement in DI did not correlate with percent stenosis.
Exogenous supplementation of antithrombin III in adult and pediatric patients receiving extracorporeal membrane oxygenation
Authors: Sorial Mark N , Greene Rebecca A , Zullo Andrew R , Berard-Collins Christine , Willis Steve 
Published: November 2019

Background: Antithrombin III deficiency can occur with heparin anticoagulation during extracorporeal membrane oxygenation leading to heparin resistance. Antithrombin III supplementation has been shown to improve anticoagulation; however, there is no consensus on appropriate administration. We described the effect of antithrombin III supplementation on coagulation parameters in adult and pediatric extracorporeal membrane oxygenation patients. Methods: We conducted a retrospective cohort study using electronic medical records of patients who received ⩾1 dose of antithrombin III during extracorporeal membrane oxygenation while on continuous heparin. Endpoints included the change in anti-Xa levels and antithrombin III activity at −6 versus 6 h relative to antithrombin III supplementation, and heparin infusion rates at 6 versus 12 h after antithrombin III supplementation. Results: Eighteen patients receiving 36 antithrombin III administrations were analyzed. Mean (standard deviation) anti-Xa values at −6 versus 6 h were 0.15 (0.07) versus 0.24 (0.15) IU/mL ( p-value: 0.250) for pediatrics and 0.19 (0.22) versus 0.31 (0.27) IU/mL ( p-value: 0.052) for adults. Mean (standard deviation) plasma antithrombin III activity at the same intervals were 32% (14.2%) versus 66.8% (25.1%; p-value: 0.062) for pediatrics and 30.3% (14%) versus 52.8% (8.1%; p-value: 0.094) for adults. Mean (standard deviation) heparin rates at 6 versus 12 h after antithrombin III for pediatrics were 23.6 (6) versus 23.5 (6.5) units/kg/h ( p-value: 0.728), and 15.3 (6.6) versus 13.5 (8) units/kg/h ( p-value: 0.188) for adults. Conclusion: Administration of antithrombin III improved anti-Xa levels in both populations, however, did not significantly reduce heparin rates. Our findings suggest that the use of antithrombin III restores heparin responsiveness in patients with low antithrombin III activity and low anti-Xa activity.
The Design of Experiments in Occupational Ergonomics Research: Issues and Challenges
Authors: Fox Bob , Mines Dan , Cort Joel , Jones Monica , Lu Ming-Lun , Potvin Jim , Rempel David 
Published: November 2019

As with all scientific disciplines involving research (laboratory or field), the design of an experiment, and the statistical methods used, are critical factors in research rigor, thus in our ability to compare, evaluate and communicate research findings. Courses in experimental design and statistics are required for the pursuit of advanced training in ergonomics. Across various scientific fields, there has been renewed interest in, and scrutiny of, statistical methods in establishing the validity and “truthfulness” of data, opinions, interpretations and projections of outcomes. Ergonomics researchers use distinct research methods (e.g., laboratory vs field; cross-sectional v. experimental, etc.) and must contend with a variety of constraints based on resources, availability of participants and access to the workplace. The variety of study designs chosen will challenge researchers as well as practitioners when comparing their results across published studies and attempting to generalize findings to new settings. This discussion panel will explore several the questions and issues related to research design and draw on specific studies from the literature. Topics and discussion will include study design (laboratory v field); different forms of experimental design (RCT v opportunistic); sample size and heterogeneity; non-parametric methods and differences in outcome measures and study durations. Following the presentations, ample time will be set aside for discussions of key issues with the panelists and audience. This session is relevant for the practitioners who must understand, interpret and apply the results of research to real-world problems.
HFES Goes to Washington
Authors: Endsley Mica , Saab Nick , Cao Caroline , Handley Holly , Harris-Adamson Carisa 
Published: November 2019

Learn how HFES members can get involved in advocating for the science of human factors and ergonomics (HF/E). This panel will present an overview of the Human Factors and Ergonomics Society’s activities in working to promote the science of HF/E in Congress and across government agencies. The activities of the Government Relations Committee will be discussed, to include outreach to Congress and responses to pending legislation, as well as the development of policy statements on Human Systems Integration, Airline Seating, and Autonomous Vehicles. Nicholas Saab will provide a discussion of the many activities Lewis-Burke Associates engages in on behalf of HFES. As our government relations experts, Lewis-Burke tracks relevant legislation, and activities and opportunities for HF/E involvement in supporting government operations across its many agencies. They help represent the society on the ground in DC and provide inputs on our behalf across a wide range of topics. New to HFES, the Science Policy Fellows program was established in 2018 to provide a valuable opportunity for members to learn how to navigate the federal policy process and successfully advocate for human factors and ergonomics on the national stage. They receive extensive training in public affairs, advocacy, and outreach, and represent HFES in an annual Capitol Hill day in Washington, DC. In addition to working with the Government Relations Committee, the Science Policy Fellows are each developing a tailored outreach program to include continued participation in Capitol Hill Day and interactions with policy makers in DC, supporting the Society’s policy objectives at the local and/or state level, serving on the GRC or a subcommittee, or other activities developed by each participant. Our 2018 Science Policy Fellows, Caroline Cao, Holly Handley and Carisa Harris-Adamson, will each present on their experiences and activities. This special session provides an opportunity for HFES members to learn more about how the society is representing and supporting our profession in Washington, and about how they can get involved in promoting human factors and ergonomics at the local, state or national level.
The Effects of Restricted Sight Distances on Drivers at Simulated Rural Intersections
Authors: Achtemeier Jacob , Craig Curtis M. , Morris Nichole L. 
Published: November 2019

Short sight distances at rural intersections can result in reduced safety including drivers choosing smaller gaps between oncoming vehicles (Yan & Richards, 2010). Conversely, increased sight distances may result in improved driver confidence, but not safety as seen at rail crossings (Ward & Wilde, 1996). Thus, simply increasing sight distances may not result in linear gains in safety. Establishing appropriate lower and upper-visibility limits at rural intersections will minimize operational costs for clearing and grubbing labor and may reduce serious injury and fatal crashes by promoting safer crossing behavior around rural thru-STOP intersections. This driving simulation study will examine intersection visibility and other intersection design factors that influence driver behavior at rural thru-STOPs. Time to collision, or TTC, is a primary motivating factor on driver decisions to cross intersections. Drivers’ TTC perception is a function of oncoming vehicle speed, distance, and rate of retinal expansion (tau; Hancock & Manser, 1997). We hypothesize TTC factors may interact with confidence in intersection crossing judgments. Specifically, when people must quickly make judgments, their confidence must be estimated after the decision has been made, but if the time pressure is not high and the decision is not immediate, people’s judgments and their confidence in those judgments can both be considered prior to action. This can be problematic because people are normally overconfident in their judgments (Harvey, 1997). The present study comprised a crossing judgment block, and a mainline drive block. The experimental stimuli were validated by engineers with experience in rural intersections, who rated the simulated intersections as “significantly representative” to real-world intersections through an average rating score of 5.25 ( SD = 0.5) on a 7-pt scale. This was done to ensure that the study findings would be more likely to be applicable to world intersections. The goal of the study is to identify whether sight distance and other variables, including speed for the judgment task and vehicle proximity to the intersection for the mainline drive task, impact safety at rural intersections.
Prevalence and incidence of neuromyelitis optica spectrum disorder and multiple sclerosis in Korea
Authors: Kim Jee-Eun , Park Sang-Hyun , Han Kyungdo , Kim Ho Jin , Shin Dong-Wook , Kim Sung-Min 
Published: November 2019

Background: The epidemiology of neuromyelitis optica spectrum disorder and multiple sclerosis varies depending on the region and ethnicity. Objective: To estimate the prevalence and incidence of neuromyelitis optica spectrum disorder and multiple sclerosis in Korea during 2010–2016. Methods: We analyzed the National Health Insurance research database, which contains single-payer health insurance data collected in Korea. Neuromyelitis optica spectrum disorder was defined based on the 2006 Wingerchuk criteria (for 2010–2015), and the 2015 International Panel for Neuromyelitis Optica Diagnosis criteria (for 2016). Multiple sclerosis was defined by the 2005 International Panel criteria for multiple sclerosis. Results: In 2016, the age-standardized prevalence per 100,000 persons was 2.56 (95% confidence interval: 2.43–2.7) for neuromyelitis optica spectrum disorder and 3.23 (95% confidence interval: 3.08–3.39) for multiple sclerosis. The age-standardized incidence of neuromyelitis optica spectrum disorder and multiple sclerosis were 0.73 (95% confidence interval: 0.66–0.8) and 0.50 (95% confidence interval: 0.44–0.56) per 100,000 persons in 2016. The prevalence of neuromyelitis optica spectrum disorder and multiple sclerosis have increased over time during 2010–2016 (18.5% and 5.4% annually; both p-trend < 0.001). The incidence of neuromyelitis optica spectrum disorder increased annually (10.0%, p-trend < 0.001), while the incidence of multiple sclerosis remained stable. Conclusion: While the prevalence of neuromyelitis optica spectrum disorder and multiple sclerosis are comparable in Korea, the incidence of neuromyelitis optica spectrum disorder is higher than that of multiple sclerosis. Both the prevalence and incidence of neuromyelitis optica spectrum disorder are rapidly increasing in Korea.
Comparison of Outcomes Following Infrapopliteal Plain Balloon Angioplasty in the BASIL Trial (1999-2004) and in a Contemporary Series (2009-2013)
Authors: Popplewell Matthew A. , Davies Huw O.B. , Renton Mary , Bate Gareth , Patel Smitaa , Deeks Jonathan J. , Bradbury Andrew W. 
Published: November 2019

Objectives: To compare outcomes in patients randomized to infrapopliteal (IP) plain balloon angioplasty (PBA) for chronic limb-threatening ischemia within the Bypass versus Angioplasty in Severe Ischemia of the Leg (BASIL)-1 trial between 1999 and 2004 with outcomes in consecutive patients undergoing IP PBA at an academic vascular unit a decade later (2009-2013, Contemporary series [CS]). Methods: Individual patient data were obtained from prospective BASIL-1 (48 patients) and CS databases (73 patients). All had a minimum of 3-years of follow-up. Outcomes studied were amputation-free survival (AFS), overall survival (OS), major (above ankle) limb amputation, arterial reintervention, immediate technical success, and length of hospital stay for the index procedure and during the following 12-month period. Statistical analysis was performed using SAS version 9.4. Results: The BASIL and CS cohorts were well matched for gender, age, diabetes, previous stroke, myocardial infarction and arterial intervention, and presence of tissue loss. More patients in BASIL-1 underwent concomitant treatment of the superficial femoral (60% vs 37%, P = .01) and above knee popliteal (60% vs 34%, P = .005) arteries. Immediate technical success increased from 73% in BASIL-1 to 90% in the CS ( P = .01). Between the two cohorts, there were no differences in AFS (hazard ratio [HR] = 1.00, 95% confidence interval [CI]: 0.65-1.54, P = 1.0), OS (HR = 1.04, 95% CI: 0.66-1.62, P = .9), major amputation (HR = 0.86, 95% CI: 0.37-1.97, P = .7), or reintervention (HR = 0.61, 95% CI: 0.29-1.27, P = .2). Contemporary series patients spent significantly fewer days in hospital following the index procedure ( P = .02) and also over the following 12 months ( P = .002). Conclusions: Despite improvements in the immediate technical angiographic success of IP PBA between BASIL and the CS, there were no significant improvements in survival outcomes. Results from BASIL-2 and BEST-CLI are required in order to properly define the clinical and cost-effectiveness of endovascular treatment in such patients.
Quantifying the Impact of Influenza Among Persons With Type 2 Diabetes Mellitus: A New Approach to Determine Medical and Physical Activity Impact
Authors: Samson Sandrine I. , Konty Kevin , Lee Wei-Nchih , Quisel Tom , Foschini Luca , Kerr David , Liska Jan , Mills Henry , Hollingsworth Rosalind , Greenberg Michael , Beal Anne C. 
Published: November 2019

Background: We describe the impact of influenza on medical outcomes and daily activities among people with and without type 2 diabetes mellitus (T2DM). Methods: Retrospective cohort analysis of a US health plan offering a digital wellness platform connecting wearable devices capable of tracking steps, sleep, and heart rate. For the 2016 to 2017 influenza season, we compared adults with T2DM to age and gender matched controls. Medical claims were used to define cohorts and identify influenza events and outcomes. Digital tracking data were aggregated at time slices of minute-, day-, week-, and year-level. A pre-post study design compared the peri-influenza period (two weeks before and four weeks after influenza diagnosis) to the six-week preceding period (baseline). Results: A total of 54 656 T2DM and 113 016 non-DM controls were used for the study. People with T2DM had more influenza claims, vaccinations, and influenza antivirals per 100 people (1.96% vs 1.37%, 34.3% vs 24.3%, and 27.1 vs 22 respectively, P < .001). A total of 1086 persons with T2DM and 1567 controls had an influenza claim (47.4% male, median age 54, 6.4% vs 7.8% trackers, respectively). Glycemic events, pneumonia, and ischemic heart disease increased over baseline during the peri-influenza period for T2DM (1.74-, 7.4-, and 1.6-fold increase respectively, P < .01). In a device wearing subcohort, we observed 10 000 fewer steps surrounding the influenza event, with the lowest (5500 steps) two days postinfluenza. Average heart rate increased significantly (+5.5 beats per minute) one day prior to influenza. Conclusion: Influenza increases rates of pneumonia, heart disease, and abnormal glucose levels among people with T2DM, and negatively impacts daily activities compared to controls.
Down-regulation of miR-30b-5p protects cardiomyocytes against hypoxia-induced injury by targeting Aven
Authors: Zhang Lanfang , Jia Xinwei 
Published: November 2019

Abstract
Background
Ischemia/hypoxia-induced cardiomyocyte apoptosis has been considered as a main cause of myocardial infarction. Here, we aimed to investigate the functional role of miR-30b-5p in hypoxic cardiomyocytes.

Methods
AC16 human cardiomyocytes were cultured under hypoxia to simulate myocardial infarction. A qRT-PCR assay was performed to determine miR-30b-5p expression in hypoxic cardiomyocytes. Cell survival, injury and apoptosis were assessed by MTT, lactate dehydrogenase (LDH) release, and flow cytometry assays, respectively. The target gene of miR-30b-5p in hypoxic cardiomyocytes was validated by luciferase reporter assay and Western blotting.

Results
MiR-30b-5p expression was found to be significantly upregulated in hypoxic AC16 cells. The in vitro experiments showed that downregulation of miR-30b-5p effectively alleviated hypoxia-induced cardiomyocyte injury. Furthermore, Aven is a potential target gene of miR-30b-5p and its downregulation could partially reverse the influence of miR-30b-5p knockdown on AC16 cells under hypoxia.

Conclusions
Inhibition of miR-30b-5p could protect cardiomyocytes against hypoxia-induced injury by targeting Aven.
Functional Haplotype and eQTL Analyses of Genes Affecting Cadmium Content in Cultivated Rice
Authors: Lee Sang-Beom , Kim Gyeong-Jin , Kim Kyu-Won , Chu Sang-Ho , Shin Jung-Du , Lee Yu-Ji , Park Yong-Jin , Park Sang-Won 
Published: November 2019

Abstract
Background
Rice is a major food resource for Asian countries including Korea. However, most Asian countries are facing food safety problems due to cropland contamination by heavy metals. Thus, this study was conducted to investigate genetic factors affecting the expression of cadmium (Cd) gene, and to confirm differences in Cd translocation among cultivars because the current molecular understanding of Cd uptake-transport mechanisms remains insufficient. Associations between genotypes and gene expression level of Cd-related genes such as NRAMP, MTP, and HMA gene families in the rice core collection were analyzed at the genomic level.

Results
Os01g0956700, Os05g0128400 and Os11g0485200 showed strong associations between expression level and genotype in the rice core collection, the regulatory factors that associated with these genes in cis and trans were founded. The association between the expression level and genotype of the candidate gene (Os01g0611300: metal tolerance protein) predicted to affect Cd content in rice by a previous genome-wide association study (GWAS) was also analyzed. Furthermore, as a result of the phylogeny and haplotype analyses of the candidate gene, high-Cd tolerance cultivars were selected. The correlations between Cd and other inorganic components (Mg, Mn, Fe, Cu and Zn) in the roots, stems, leaves and unpolished grain of selected rice cultivars were analyzed.

Conclusion
Therefore, these results may be useful for understanding the uptake-transport mechanisms of Cd and other inorganic components via molecular genetics and may help rice breeders develop new low-Cd cultivars in the near future.