bluuebunny/crossref_metadata_2025_split huggingface dataset:
FTY720, a sphingosine analog, altered placentome histoarchitecture in ewes
Authors: Dunlap Kathrin A. , White Bryan G. , Erikson David W. , Satterfield M. Carey , Pfarrer Christiane , Wu Guoyao , Bazer Fuller W. , Burghardt Robert C. , Bayless Kayla J. , Johnson Greg A. 
Published: January 2020

Abstract
Background
The lysosphingolipid, sphingosine-1-phosphate, is a well-described and potent pro-angiogenic factor. Receptors, as well as the sphingosine phosphorylating enzyme sphingosine kinase 1, are expressed in the placentomes of sheep and the decidua of rodents; however, a function for this signaling pathway during pregnancy has not been established. The objective of this study was to investigate whether sphingosine-1-phosphate promoted angiogenesis within the placentomes of pregnant ewes. Ewes were given daily jugular injections of FTY720 (2-amino-2[2-(− 4-octylphenyl)ethyl]propate-1,3-diol hydrochloride), an S1P analog.

Results
FTY720 infusion from days 30 to 60 of pregnancy did not alter maternal organ weights nor total number or mass of placentomes, but did alter placentome histoarchitecture. Interdigitation of caruncular crypts and cotyledonary villi was decreased, as was the relative area of cotyledonary tissue within placentomes. Also, the percentage of area occupied by cotyledonary villi per unit of placentome was increased, while the thickness of the caruncular capsule was decreased in ewes treated with FTY720. Further, FTY720 infusion decreased the number and density of blood vessels within caruncular tissue near the placentome capsule where the crypts emerge from the capsule. Finally, FTY720 infusion decreased asparagine and glutamine in amniotic fluid and methionine in allantoic fluid, and decreased the crown rump length of day 60 fetuses.

Conclusions
While members of the sphingosine-1-phosphate signaling pathway have been characterized within the uteri and placentae of sheep and mice, the present study uses FTY720 to address the influence of S1P signaling on placental development. We present evidence that modulation of the S1P signaling pathway results in the alteration of caruncular vasculature, placentome architecture, abundance of amino acids in allantoic and amniotic fluids, and fetal growth during pregnancy in sheep. The marked morphological changes in placentome histoarchitecture, including alteration in the vasculature, may be relevant to fetal growth and survival. It is somewhat surprising that fetal length was reduced as early as day 60, because fetal growth in sheep is greatest after day 60. The subtle changes observed in the fetuses of ewes exposed to FTY720 may indicate an adaptive response of the fetuses to cope with altered placental morphology.
The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits
Authors: Amadi Cecilia Nwadiuto , Nwachukwu Wisdom Izuchukwu 
Published: January 2020

Abstract
Background
Cola nitida is commonly chewed in many West African cultures to ease hunger pangs and sometimes for their stimulant and euphoriant qualities. Metoclopramide is a known substrate for P-gp, SULT2A1 and CYP2D6 and studies have revealed that caffeine- a major component of Cola nitida can induce P-glycoprotein (P-gp), SULT2A1 and SULT1A1, hence a possible drug interaction may occur on co-administration. The aim of this study was to investigate the pharmacokinetic interactions of Cola nitida and metoclopramide in rabbits.

Methods
The study was performed in two stages using five healthy male rabbits with a 1-week washout period between treatments. Stage one involved oral administration of metoclopramide (0.5 mg/kg) alone while in the second stage, metoclopramide (0.5 mg/kg) was administered concurrently with Cola nitida (0.7 mg/kg). Blood samples were collected after each stage at predetermined intervals and analyzed for plasma metoclopramide concentration using HPLC.

Results
Compared with control, the metoclopramide/Cola nitida co-administration produced a decrease in plasma concentration of metoclopramide at all the time intervals except at the 7th hour. The following pharmacokinetic parameters were also decreased: area under the curve (51%), peak plasma concentration (39%), half-life (51%); while an increase in elimination rate constant (113%) and clearance rate (98%) were noted indicating rapid elimination of the drug. A minimal decrease in absorption rate (10%) was also observed.

Conclusions
The results of this study reveal a possible herb-drug interaction between Cola nitida and metoclopramide.
Broad consent under the GDPR: an optimistic perspective on a bright future
Authors: Hallinan Dara 
Published: January 2020

AbstractBroad consent – the act of gaining one consent for multiple potential future research projects – sits at the core of much current genomic research practice. Since the 25th May 2018, the General Data Protection Regulation (GDPR) has applied as valid law concerning genomic research in the EU and now occupies a dominant position in the legal landscape. Yet, the position of the GDPR concerning broad consent has recently been cause for concern in the genomic research community. Whilst the text of the GDPR apparently supports the practice, recent jurisprudence contains language which is decidedly less positive. This article takes an in-depth look at the situation concerning broad consent under the GDPR and – despite the understandable concern flowing from recent jurisprudence – offers a positive outlook. This positive outlook is argued from three perspectives, each of which is significant in defining the current, and ongoing, legitimacy and utility of broad consent under the GDPR: the principled, the legal technical, and the practical.
Soil salinity assessment by using near-infrared channel and Vegetation Soil Salinity Index derived from Landsat 8 OLI data: a case study in the Tra Vinh Province, Mekong Delta, Vietnam
Authors: Nguyen Kim-Anh , Liou Yuei-An , Tran Ha-Phuong , Hoang Phi-Phung , Nguyen Thanh-Hung 
Published: January 2020

AbstractSalinity intrusion is a pressing issue in the coastal areas worldwide. It affects the natural environment and causes massive economic loss due to its impacts on the agricultural productivity and food safety. Here, we assessed the salinity intrusion in the Tra Vinh Province, in the Mekong Delta of Vietnam. Landsat 8 OLI image was utilized to derive indices for soil salinity estimate including the single bands, Vegetation Soil Salinity Index (VSSI), Soil Adjusted Vegetation Index (SAVI), Normalized Difference Vegetation Index (NDVI), and Normalized Difference Salinity Index (NDSI). Statistical analysis between the electrical conductivity (EC1:5, dS/m) and the environmental indices derived from Landsat 8 OLI image was performed. Results indicated that spectral values of near-infrared (NIR) band and VSSI were better correlated with EC1:5(r2= 0.8 andr2= 0.7, respectively) than the other indices. Comparative results show that soil salinity derived from Landsat 8 was consistent with in situ data with coefficient of determination,R2= 0.89 and RMSE = 0.96 dS/m for NIR band andR2= 0.77 and RMSE = 1.27 dS/m for VSSI index. Findings of this study demonstrate that Landsat 8 OLI images reveal a high potential for spatiotemporally monitoring the magnitude of soil salinity at the top soil layer. Outcomes of this study are useful for agricultural activities, planners, and farmers by mapping thesoil salinitycontamination for better selection of accomodating crop types to reduce economical loss in the context of climate change. Our proposed method that estimates soil salinity using satellite-derived variables can be potentially useful as a fast-approach to detect the soil salinity in the other regions with low cost and considerable accuracy.
Application of wavelet for seismic wave analysis in Kathmandu Valley after the 2015 Gorkha earthquake, Nepal
Authors: Adhikari Binod , Dahal Subodh , Karki Monika , Mishra Roshan Kumar , Dahal Ranjan Kumar , Sasmal Sudipta , Klausner Virginia 
Published: January 2020

AbstractIn this paper, we estimate the seismogenic energy during the Nepal Earthquake (25 April 2015) and studied the ground motion time-frequency characteristics in Kathmandu valley. The idea to analyze time-frequency characteristic of seismogenic energy signal is based on wavelet transform which we employed here. Wavelet transform has been used as a powerful signal analysis tools in various fields like compression, time-frequency analysis, earthquake parameter determination, climate studies, etc. This technique is particularly suitable for non-stationary signal. It is well recognized that the earthquake ground motion is a non-stationary random process. In order to characterize a non-stationary random process, it is required immeasurable samples in the mathematical sense. The wavelet transformation procedures that we follow here helps in random analyses of linear and non-linear structural systems, which are subjected to earthquake ground motion. The manners of seismic ground motion are characterized through wavelet coefficients associated to these signals. Both continuous wavelet transform (CWT) and discrete wavelet transform (DWT) techniques are applied to study ground motion in Kathmandu Valley in horizontal and vertical directions. These techniques help to point out the long-period ground motion with site response. We found that the long-period ground motions have enough power for structural damage. Comparing both the horizontal and the vertical motion, we observed that the most of the high amplitude signals are associated with the vertical motion: the high energy is released in that direction. It is found that the seismic energy is damped soon after the main event; however the period of damping is different. This can be seen on DWT curve where square wavelet coefficient is high at the time of aftershock and the value decrease with time. In other words, it is mostly associated with the arrival of Rayleigh waves. We concluded that long-period ground motions should be studied by earthquake engineers in order to avoid structural damage during the earthquake. Hence, by using wavelet technique we can specify the vulnerability of seismically active region and local topological features out there.
Evaluation of landslide hazard and its impacts on hilly environment of the Nilgiris District - a geospatial approach
Authors: Thennavan Edison , Pattukandan Ganapathy Ganapathy 
Published: January 2020

AbstractLandslide Hazard Zonation (LSH) maps play a key role in landuse planning particularly in landslide prone areas. LSH mapping is globally accepted one for analyzing the area for landslide susceptibility. Different approaches were followed by many researchers in India to prepare landslide hazard zonation mapping depending upon their need and requirement. The Nilgiris district in Western Ghats of India is one of the severe to high landslide hazard prone areas of India. Many agencies have carried out research on LSH mapping for the Nilgiris district with different scales. A systematic study of inventory and zonation was 122carried out in 1980’s by government agencies. However there is no proper updation or documentation on landslides after 1980’s in the district The purpose of this paper is to review the existing landslide-related studies in the district of The Nilgiris and review the district’s existing landslide hazard map with updated information. Landslide hazard maps in The Nilgiris were compiled in the GIS platform from various authenticated sources. Data on landslides from 1824 to 2014 were collected and a spatial database on landslides was created. A detailed inventory was analyzed and used for revision of the district’s landslide hazard impact on the 2009 landslides.. Based on the landslide inventory and densely populated areas and repeated landslides at the same locations, the most landslide hazard areas were identified.
‘Neo-Crosssexual’ fashion in contemporary men’s suits
Authors: Lee Hoe Ryung , Kim Jongsun , Ha Jisoo 
Published: January 2020

AbstractToday, fashionable menswear is appropriating traditionally feminine design elements on an unparalleled international scale. This phenomenon should not be interpreted purely as a subversive gender issue, but should also be viewed as an expression of personal style and taste. In order to properly describe this phenomenon, the term ‘crosssexual’ must be introduced to English fashion vocabulary. This paper examines the innovative design characteristics of contemporary crosssexual menswear emerging prominently in men’s suits since 2015 and also raises the necessity of coining a new term: ‘neo-crosssexual’. Ultimately, this paper reveals how neo-crosssexual fashion employs a great variety of innovative silhouettes and novel design elements—ranging from structural or decorative details to colors, fabrics, patterns, and accessories—all of which enable the wearer to express whatever image of themselves they desire. Previous studies have interpreted crosssexual fashion as men simply portraying themselves as effeminate by wearing such clothing, but this conclusion is reductive and reveals there is still an unconscious recognition of limiting binary associations. The richness of neo-crosssexual fashion design, rather, gives individuals freedom to choose a sartorial image devoid of binary constraints. Conventionally classified ‘feminine designs’ are now perceived as creative and functional means to fluidity. This positive cultural shift has led to an increasing number of men choosing to wear suits that incorporate ‘feminine’ design elements, freeing this traditional garment from its limited formal use and symbolic hegemonic power.
Prostate cancer survivors’ preferences on the delivery of diet and lifestyle advice: a pilot best-worst discrete choice experiment
Authors: Robles Luke A. , Wright Stuart J. , Hackshaw-McGeagh Lucy , Shingler Ellie , Shiridzinomwa Constance , Lane J. Athene , Martin Richard M. , Burden Sorrel 
Published: January 2020

Abstract
Background
Lifestyle factors, including diet and physical activity, are associated with prostate cancer progression and mortality. However, it is unclear how men would like lifestyle information to be delivered following primary treatment. This study aimed to identify men’s preferences for receiving lifestyle information.

Methods
We conducted a cross-sectional pilot best-worst discrete choice experiment which was nested within a feasibility randomised controlled trial. Our aim was to explore men’s preferences of receiving diet and physical activity advice following surgery for localised prostate cancer. Thirty-eight men with a mean age of 65 years completed best-worst scenarios based on four attributes: (1) how information is provided; (2) where information is provided; (3) who provides information; and (4) the indirect cost of receiving information. Data was analysed using conditional logistic regression. Men’s willingness to pay (WTP) for aspects of the service was calculated using an out-of-pocket cost attribute.

Results
The combined best-worst analysis suggested that men preferred information through one-to-one discussion β = 1.07, CI = 0.88 to 1.26) and not by email (β = − 1.02, CI = − 1.23 to − 0.80). They preferred information provided by specialist nurses followed by dietitians (β = 0.76, CI = 0.63 to 0.90 and − 0.16, CI = − 0.27 to − 0.05 respectively) then general nurses (β = − 0.60, CI = − 0.73 to − 0.48). Three groups were identified based on their preferences. The largest group preferred information through individual face-to-face or group discussions (β = 1.35, CI = 1.05 to 1.63 and 0.70, CI = 0.38 to 1.03 respectively). The second group wanted information via one-to-one discussions or telephone calls (β = 1.89, CI = 1.41 to 2.37 and 1.03, CI = 0.58 to 1.48 respectively), and did not want information at community centres (β = − 0.50, CI = − 0.88 to − 0.13). The final group preferred individual face-to-face discussions (β = 0.45, CI = 0.03 to 0.88) but had a lower WTP value (£17).

Conclusions
Men mostly valued personalised methods of receiving diet and physical activity information over impersonal methods. The out-of-pocket value of receiving lifestyle information was important to some men. These findings could help inform future interventions using tailored dietary and physical activity advice given to men by clinicians following treatment for prostate cancer, such as mode of delivery, context, and person delivering the intervention. Future studies should consider using discrete choice experiments to examine information delivery to cancer survivor populations.
Isolated ACTH deficiency during single-agent pembrolizumab for squamous cell lung carcinoma: a case report
Authors: Tanaka Sho , Kushimoto Masaru , Nishizawa Tsukasa , Takubo Masahiro , Mitsuke Kazutaka , Ikeda Jin , Fujishiro Midori , Ogawa Katsuhiko , Tsujino Ichiro , Suzuki Yutaka , Abe Masanori 
Published: January 2020

Abstract
Background
The programmed cell death 1 (PD-1) inhibitor pembrolizumab is a promising agent for treatment of several different malignancies, but as with all immunotherapy there is a potential risk of immune-related adverse events. Adrenocorticotropic hormone (ACTH) deficiency and hypophysitis have been reported in patients treated with a different PD-1 inhibitor, nivolumab. However, clinical characteristics of these side effects associated with pembrolizumab have yet to be described in detail.

Case presentation
An 85-year-old Japanese woman was diagnosed with advanced squamous cell lung cancer. The patient was treated with 200 mg pembrolizumab every three weeks as first-line therapy. Routine examination including thyroid function, complete blood count, serum cortisol and sodium levels before each pembrolizumab infusion had shown no significant changes up to the eighth cycle. However, 8 days after the eighth cycle of single-agent pembrolizumab, she presented with rapidly worsening general fatigue and appetite loss over two days. Laboratory data revealed a low serum cortisol level (0.92 μg/dL) with inappropriately low ACTH (8.3 pg/mL), hyponatremia (122 mmol/L) and hypoglycemia (68 mg/dL). Standard-dose short ACTH testing showed an unsatisfactory cortisol response, indicating adrenal insufficiency. Pituitary magnetic resonance imaging showed diffuse substantial gadolinium enhancement, T2 hyperintensity, loss of pituitary bright spot, but no pituitary enlargement. Serum cortisol and ACTH levels were low throughout the day, and urinary free cortisol excretion fell below the lower normal limit. There was no ACTH and cortisol response in the corticotropin-releasing hormone test, despite significant responses of other anterior pituitary hormones to their corresponding challenge tests. Thus, isolated ACTH deficiency was diagnosed, and hypophysitis was suspected as the etiology. After administration of 15 mg/day hydrocortisone, the patient’s debilitation, hyponatremia, and hypoglycemia swiftly disappeared.

Conclusion
This is a case of isolated ACTH deficiency possibly due to hypophysitis in a patient with advanced lung cancer, in whom recent routine examinations had shown unremarkable results. We therefore conclude that isolated ACTH deficiency can suddenly arise during pembrolizumab monotherapy, albeit probably only rarely. Caution should be exercised to make sure that adrenal insufficiency is recognized immediately in order to achieve swift recovery by steroid replacement.
Learning from patient involvement in a clinical study analyzing PET/CT in women with advanced breast cancer
Authors: Vogsen Marianne , Geneser Susanne , Rasmussen Marie Lykke , Hørder Mogens , Hildebrandt Malene Grubbe 
Published: January 2020

Abstract
Background
Despite increasing interest in patient involvement in health care research, researchers may be uncertain about the benefits of involving patients in the design and conduction of clinical studies. We aimed to evaluate the impact of patient involvement on patient recruitment and retention in a clinical study of PET/CT in women with advanced breast cancer. Further, we report our experience regarding the researchers’ attitudes towards involving patients as partners in the research process.

Methods
Two patient representatives from the Danish Breast Cancer Organization were invited as partners in the research team. These patient partners were asked to contribute in particular to participator information material and evaluation of ethical aspects of the study. The impact of patient involvement on patient recruitment was evaluated by comparing expected versus actual number of patients recruited, and then relating it to patient recruitment in a similar study at the same institution that did not involve patients as research partners.

Results
Having patients as partners in the research team led to a major revision of the participator information material and improved patient recruitment. The expected number of patients was 260, but 380 were actually enrolled within the planned study period, thus 146% of the expected patient recruitment. In the previous study, only 100 of the expected 150 patients were enrolled during a 10-month extended study period, i.e. 67% of the expected number. Patient retention in the current study was high, with 86% of eligible patients attending follow-up scans. We observed initial resistance amongst researchers against inviting patients as team partners. This resistance gradually lessened during the study, and the most reluctant researchers at the beginning of the study later applauded the collaboration and the ideas generated by the patient representatives.

Conclusion
Involving patients as partners in the research team resulted in major changes to the participator information material and contributed to higher than expected patient recruitment and retention. Furthermore, we observed a positive change of attitude amongst the researchers towards patient involvement in the research process.

Trial registration
Ongoing study: ClinicalTrials.gov (NCT03358589).
Previous study: ClinicalTrials.gov (NCT01552655).