bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgery of the amygdala and uncus: a case series of glioneuronal tumors
Authors: Vivas Andrew C. , Reintjes Stephen , Shimony Nir , Vale Fernando L. 
Published: January 2020

Abstract
Background
Patients with a lesion within the amygdala and uncus may develop temporal lobe epilepsy despite having functional mesial structures. Resection of functional hippocampus and surrounding structures may lead to unacceptable iatrogenic deficits. To our knowledge, there is limited descriptions of surgical techniques for selectively resecting the amygdala and uncus lesions while preserving the hippocampus in patients with language-dominant temporal lobe pathology.

Methods
Thirteen patients with language-dominant temporal lobe epilepsy related to amygdala-centric lesions were identified. Patients with sclerosis of the mesial structures or evidence of pathology outside of the amygdala-uncus region were excluded. Neuropsychological evaluation confirmed normal function of the mesial structures ipsilateral to the lesion. All patients were worked up with video-EEG, high-resolution brain MRI, neuro-psychology evaluation, and either Wada or functional MRI testing.

Results
All patients underwent selective resection of the lesion including amygdala and uncus with preservation of the hippocampus via a transcortical inferior temporal gyrus approach to the mesial temporal lobe. Pathology was compatible with glioneuronal tumors. Post-operative MRI demonstrated complete resection in all patients. Eight of the thirteen patients underwent post-operative neuropsychology evaluations and did not demonstrate any significant decline in tasks of delayed verbal recall or visual memory based on the Rey Auditory Verbal Learning Test (RAVLT). One patient showed a slight decrease in confrontation naming using the Boston Naming Test (BNT). Seizure freedom (Engel class I) was achieved in 12 of 13 patients.

Conclusion
Selective transcortical amygdala and uncus resection with hippocampus preservation may be a reasonable way to achieve seizure control while sparing functional mesial structures.
Economic Crisis, Poor Governance and the Rise of Populism: The Case of Greece
Authors: Halikiopoulou Daphne 
Published: January 2020

AbstractWhereas across Western Europe, the salience of an emerging cultural cleavage has triggered the rise of right-wing populist parties that focus on immigration, in Greece the salience of the materialist cleavage exacerbated by the country’s severe and protracted economic crisis gave rise to populist forces of both the right and the left.
A Simple HPLC–UV Approach for Rapid Enantioseparation of Cathinones, Pyrovalerones and Other Novel Psychoactive Substances on a 2.5-µm Cellulose Tris-(3,5-dimethylphenyl-carbamate) Column
Authors: Hägele Johannes S. , Seibert Elisabeth , Schmid Martin G. 
Published: January 2020

AbstractThe misuse of so called novel psychoactive substances is still a challenging problem worldwide. A special attribute of a lot of these compounds is a chiral centre enabling two possible enantiomers probably related to different pharmacological and toxicological properties. The goal of the present study was to present a simple and isocratic HPLC–UV method for enantioseparation of mainly cathinone and pyrovalerone derivatives as well as selected representatives of amphetamines, ketamines, benzofuries, phenidines, phenidates, morpholines and thiophenes. A Waters Acquity UPC2® Trefoil™ CEL1 2.5 µm, 3.0 × 150 mm column served as chiral stationary phase by means of cellulose tris-(3,5-dimethylphenylcarbamate) as chiral selector. Mobile phases consisted either of n-hexane/n-butanol/diethylamine (100:0.3:0.2) or n-hexane/diethylamine (100:0.2). The method was found to be applicable for rapid simultaneous chiral separations of cathinone derivatives, to determine enantiomeric elution orders, to detect positional isomers and to identify real-life samples. Also, a repeatability study was performed successfully. 78 out of 95 compounds were separated in their enantiomers successfully, 51 of them within 6 min. It was shown that all NPS bought from online vendors or seized by police were traded as racemic mixtures.
Autonomous ballistic airdrop of objects from a small fixed-wing unmanned aerial vehicle
Authors: Mathisen Siri Gulaker , Leira Frederik Stendahl , Helgesen Håkon Hagen , Gryte Kristoffer , Johansen Tor Arne 
Published: January 2020

AbstractAutonomous airdrop is a useful basic operation for a fixed-wing unmanned aerial system. Being able to deliver an object to a known target position extends operational range without risking human lives, but is still limited to known delivery locations. If the fixed-wing unmanned aerial vehicle delivering the object could also recognize its target, the system would take one step further in the direction of autonomy. This paper presents a closed-loop autonomous delivery system that uses machine vision to identify a target marked with a distinct colour, calculates the geographical coordinates of the target location and plans a path to a release point, where it delivers the object. Experimental results present a visual target estimator with a mean error distance of 3.4 m and objects delivered with a mean error distance of 5.5 m.
Theoretical Modeling of High-Resolution X-ray Spectra Emitted by Tungsten and Molybdenum Ions from Tokamak Plasmas
Authors: Syrocki Ł. , Słabkowska K. , Węder E. , Polasik M. , Rzadkiewicz J. 
Published: January 2020

AbstractIn order to allow the advanced interpretation of the X-ray spectra registered by the high-resolution crystal KX1 spectrometer on the JET with an ITER-like wall, especially to determine how the relative emission contributions of tungsten and molybdenum ions change during a JET discharge, the X-ray spectra have been carefully modeled over a narrow wavelength range. The simulations have been done in the framework of Collisional–Radiative model implemented in Flexible Atomic Code for an electron density (ne = 2.5 × 1019 m−3), and electron temperatures between Te = 3.0 keV and Te = 4.5 keV, typical for JET. Moreover, performed detailed analysis in the framework of the proposed procedure can be useful in determining temperature of a high temperature plasma generated in tokamaks.
The role of TP53 gain-of-function mutation in multifocal glioblastoma
Authors: Olafson Lauren R. , Gunawardena Manuri , Nixdorf Sheri , McDonald Kerrie L. , Rapkins Robert W. 
Published: January 2020

Abstract
Purpose
The phenotypic and genotypic landscapes in multifocal glioblastoma (MF GBM) cases can vary greatly among lesions. In a MF GBM patient, the rapid development of a secondary lesion was investigated to determine if a unique genetic signature could account for the apparent increased malignancy of this lesion.

Methods
The primary (G52) and secondary (G53) tumours were resected to develop patient derived models followed by functional assays and multiplatform molecular profiling.

Results
Molecular profiling revealed G52 was wild-type for TP53 while G53 presented with a TP53 missense mutation. Functional studies demonstrated increased proliferation, migration, invasion and colony formation in G53.

Conclusion
This data suggests that the TP53 mutation led to gain-of-function phenotypes and resulted in greater overall oncogenic potential of G53.
Mental Health Needs of an Emerging Latino Community
Authors: Bucay-Harari Linda , Page Kathleen R. , Krawczyk Noa , Robles Yvonne P. , Castillo-Salgado Carlos 
Published: January 2020

AbstractOver the last decade, Baltimore has become a non-traditional sanctuary city, receiving an unprecedented influx of Latino immigrants, mostly from Central America’s Northern Triangle, who are often fleeing violence in their home countries. This study explored the nature and frequency of healthcare utilization for mental health problems among uninsured/uninsurable Latinos who received outpatient care between 2012 and 2015 through an academic hospital-affiliated program that covers primary and specialty services to uninsured patients without regard to documentation status. Encounters for mental health disorders were the most common category, accounting for 14.88% of all visits. Mood (78%) and anxiety disorders (16%) were the most prevalent mental health diagnoses. The most frequent reason to seek care was symptom, signs, and ill-defined conditions (37.47%), and within this subgroup, pain was the leading cause of seeking care (88%), which may indicate high rates of somatization of mental health distress. This study presents a unique opportunity to explore the burden and nature of mental health needs among a population for which healthcare information is rarely attainable and highlights the need for culturally competent screening mechanisms and interventions to address the stressors faced by emergent communities.
Depression and Disordered Gaming: Does Culture Matter?
Authors: O’Farrell Dominic Lloyd , Baynes Kyi-Lyn , M. Pontes Halley , D. Griffiths Mark , Stavropoulos Vasileios 
Published: January 2020

AbstractThe dearth of evidence related to cultural and gender variations of established associations between Internet Gaming Disorder (IGD) and other psychopathologies has been highlighted. Accordingly, the present study examined the association between depression and disordered gaming behaviors, while considering cultural perspectives of vertical individualism (independence and hierarchy) and gender as potentially variating factors. To achieve this, an ethnically diverse online sample of internet gamers from multicultural societies (N = 1032; Australia = 738; 71.5%; USA = 222; 21.5%; other multicultural countries = 72; 13.3%; Mage = 24 years; males = 503 [48.7%], females = 529 [51.3%]) completed the Internet Gaming Disorder Scale–Short-Form (IGDS9-SF); the Depression, Anxiety and Stress Scale (DASS-21) and the Individualism and Collectivism Scale (ICS). Regression, moderation and moderated moderation analyses were conducted. Results demonstrated that gamers presenting concurrently with symptoms of depression and vertically individualistic inclinations reported higher levels of disordered gaming behaviors, with no significant gender differences. The findings obtained imply that practitioners globally, and especially in multicultural societies (e.g., Australia, USA), should consider cultural differences when developing prevention and intervention strategies for disordered gaming.
Augmentation of haptic feedback for teleoperated robotic surgery
Authors: Schleer Philipp , Kaiser Philipp , Drobinsky Sergey , Radermacher Klaus 
Published: January 2020

Abstract
Purpose
A frequently mentioned lack of teleoperated surgical robots is the lack of haptic feedback. Haptics are not only able to mirror force information from the situs, but also to provide spatial guidance according to a surgical plan. However, superposition of the two haptic information can lead to overlapping and masking of the feedback and guidance forces. This study investigates different approaches toward a combination of both information and investigates effects on system usability.

Methods
Preliminary studies are conducted to define parameters for two main experiments. The two main experiments constitute simulated surgical interventions where haptic guidance as well as haptic feedback provide information for the surgeon. The first main experiment considers drilling for pedicle screw placements, while the second main experiment refers to three-dimensional milling tasks such as during partial knee replacements or craniectomies. For both experiments, different guidance modes in combination with haptic feedback are evaluated regarding effectiveness (e.g., distance to target depth), efficiency and user satisfaction (e.g., detectability of discrepancies in case of technical guidance error).

Results
Regarding pedicle screw placements a combination of a peripheral visual signal and a vibration constitutes a good compromise regarding distance to target depth and detectability of discrepancies. For milling tasks, trajectory guidance is able to improve efficiency and user satisfaction (e.g., perceived workload), while boundary constraints improve effectiveness. If, assistance cannot be offered in all degrees of freedom (e.g., craniectomies), a visual substitution of the haptic force feedback shows the best results, though participants prefer using haptic force feedback.

Conclusion
Our results suggest that in case haptic feedback and haptic assistance are combined appropriately, benefits of both haptic modalities can be exploited. Thereby, capabilities of the human–machine system are improved compared to usage of exclusively one of the haptic information.
Generative Critique in Interdisciplinary Collaborations: From Critique in and of the Neurosciences to Socio-Technical Integration Research as a Practice of Critique in R(R)I
Authors: Smolka Mareike 
Published: January 2020

AbstractDiscourses on Responsible Innovation and Responsible Research and Innovation, in short R(R)I, have revolved around but not elaborated on the notion of critique. In this article, generative critique is introduced to R(R)I as a practice that sits in-between adversarial armchair critique and co-opted, uncritical service. How to position oneself and be positioned on this spectrum has puzzled humanities scholars and social scientists who engage in interdisciplinary collaborations with scientists, engineers, and other professionals. Recently, generative critique has been presented as a solution to the puzzle in interdisciplinary collaborations on neuroscientific experiments. Generative critique seeks to create connections across disciplines that help remake seemingly stable objects in moments when taken-for-granted ways of seeing and approaching objects are unsettled. In order to translate generative critique from the neurosciences to R(R)I, socio-technical integration research (STIR) is proposed as a practice of generative critique in interdisciplinary R(R)I collaborations. These collaborations aim to account for societal aspects in research and technology development. For this purpose, a variety of approaches have been developed, including STIR and video-reflexive ethnography (VRE). STIR and VRE resemble each other but diverge on affective, collaborative, and temporal dimensions. Their juxtaposition serves to develop suggestions for how STIR could be modified on these dimensions to better enact generative critique in interdisciplinary R(R)I collaborations. In this way, the article contributes to ongoing discussions in R(R)I and in the engaged programme in science and technology studies more broadly on the dynamics of positioning in collaborative work.
Cracking and Failure Characteristics of Flame Cut Thick Steel Plates
Authors: Jokiaho T. , Santa-aho S. , Peura P. , Vippola M. 
Published: January 2020

Abstract
The manufacturing of thick wear-resistant steel plates commonly leads to a layered structure and non-uniform properties in the thickness direction which makes the processing and utilization of the plates problematic. The processing steps of thick plates include flame cutting, which generates a heat-affected zone and high residual stresses into the cut edge. In the worst case, the cutting causes cracking. However, the residual stress level alone is not high enough to break a wear-resistant steel plate that behaves normally. Therefore, high-tensile stress also requires a microstructurally weak factor for crack initiation. For this reason, the main objective of this study is to reveal the main microstructural reasons behind the cracking of plates in flame cutting. To achieve this, plate samples containing cracks are mechanically tested and analyzed by electron microscopy. The results show that cracks are commonly formed horizontally into the tempered region of the heat-affected zone. Cracks initiate in the segregations, which typically have a higher amount of impurity and alloying elements. Increased impurity and alloying content in the segregations decreases the cohesion of the prior austenite grain boundaries. These weakened grain boundaries combined with high-residual tensile stress generate the cracks in the flame-cutting process.
Depressive Emotionality Moderates the Influence of the BDNF Val66Met Polymorphism on Executive Functions and on Unconscious Semantic Priming
Authors: Sanwald Simon , Montag Christian , Kiefer Markus 
Published: January 2020

AbstractAutomatic semantic processing can be assessed using semantic priming paradigms. Individual differences in semantic priming have been associated with differences in executive functions. The brain-derived neurotrophic factor (BDNF) Val66Met (substitution of valine (Val) to methionine (Met) at codon 66) polymorphism has been shown to be associated with executive functions as well as depression. Depression-associated variables such as depressed mood also moderated the relationship between BDNF Val66Met and executive functions in previous work. In this study, we therefore aimed at investigating whether BDNF Val66Met genotype modulates masked and unmasked semantic priming as well as executive functions and whether sadness is a moderator of these associations. We collected data of N = 155 participants measuring reaction times (RTs) as well as error rates (ERs) in masked and unmasked semantic priming paradigms using a lexical decision task. We assessed the primary emotion of SADNESS using the Affective Neuroscience Personality Scale (ANPS) and working memory using digit span forward and backward tasks. Met+ carriers showed reduced RT priming and increased ER priming in the masked priming paradigm. Even though there was no direct association between BDNF Val66Met and executive functions, SADNESS significantly moderated the association between BDNF Val66Met and executive functions as well as masked RT priming. We suggest that Met+ individuals with low depressive tendencies have not only superior EF, but also a faster and more superficial processing style, compared with Val/Val homozygotes. However, in Met+ individuals, cognitive functioning exhibits a greater vulnerability to depressed emotionality compared with Val/Val homozygotes. Our study thus demonstrates how emotional and molecular genetic factors exert an interacting influence on higher-level cognition.
Experimental and numerical studies of process variabilities in biaxial carbon fiber braids
Authors: Czichos Ruben , Bareiro Oscar , Pickett Anthony K. , Middendorf Peter , Gries Thomas 
Published: January 2020

AbstractThis paper investigates the manufacture of biaxial carbon fiber braids and the influence that different machine settings have on variability of the textile architecture produced. In parallel, numerical simulations of the braiding process with these different machine settings have been conducted. For these studies yarn tension and process speed are varied to generate cylindrical biaxial braids with an average braid angle of±45°. The overall preform quality is characterized by means of variability in braid angle, yarn width, cover factor and fiber damage, using a variety of experimental techniques. Furthermore, from the final infused composite variations in yarn cross-section dimensions have been measured. A method is presented to transfer braid process simulation results to a detailed three dimensional finite element model of the architecture using a technique based on thermal expansion and compaction simulation. This method also allows the possibility to introduce experimentally observed variability in yarn cross-section dimensions. Such a model provides a valuable starting point for mesoscopic infusion or mechanical analysis of the textile composite. A comparison between experimental and numerical results shows that the process simulation can well reproduce the real braid angles in terms of mean value and scatter under different machine configurations and that the meso-scale textile model gives a good reproduction of the true textile architecture.
The Role of the Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation After Radical Prostatectomy: A Randomized Clinical Trial
Authors: Baccaglini Willy , Pazeto Cristiano Linck , Corrêa Barros Eduardo Augusto , Timóteo Frederico , Monteiro Leonardo , Saad Rached Raiff Yusser , Navas Arthur , Glina Sidney 
Published: January 2020

Abstract

Background
Erectile dysfunction (ED) after radical prostatectomy (RP) still represents a major issue. Considering the benefits recently described regarding the application of low-intensity extracorporeal shockwave therapy (LiESWT) in vasculogenic ED, questions arise about its role in the scenario of penile rehabilitation.

Aim
To compare the early introduction of phosphodiesterase-5 inhibitor (PDE5i) with a combination therapy enrolling both early PDE5i use and LiESWT in patients submitted to RP.

Methods
This study is a randomized clinical trial, open-label, with 2 parallel arms and an allocation ratio of 1:1. The study was registered in ReBEC (ensaiosclinicos.gov.br) Trial: RBR-85HGCG. Both arms started tadalafil at a dose of 5 mg/day right after the removal of the transurethral catheter, and the experimental group received 2,400 shocks/session-week distributed on 4 different penile regions. The full treatment consisted of 19,200 impulses across 8 weeks.

Outcomes
The primary clincal end point was ≥4-point difference favoring the experimental group considering the mean International Index of Erectile Function short form (IIEF-5) at last follow-up. Any statistical difference in the IIEF-5 score between the arms was stated as the primary statistical end point.

Results
Between September 25, 2017, and December 3, 2018, 92 men were enrolled in the study. At last follow-up, we assessed 77 patients, 41 in the control group and 36 in the intervention group. A difference between groups was detected when accessing the final median IIEF-5 score (12.0 vs 10.0; P = .006). However, the primary clinical endpoint considering a difference ≥4-point between the arms has not been reached. When performing an exploratory analysis comparing the proportion of those individuals with an IIEF-5 score ≥17, no difference between groups was noted (17.1% vs 22.2%; P = .57).

Clinical Implications
So far, the benefits arising from LiESWT for penile rehabilitation after RP have been uncertain.

Strengths & Limitations
This is the first trial assessing the role of LiESWT on erectile function after RP. Our study protocol included only one session per week for the experimental group, raising a query if a more intensive application could achieve better results once a statistically significant difference was found between groups. We discontinue the PDE5i use at the last session, which may have interfered in the penile vascular rehabilitation, maybe compromising the results too.

Conclusion
After therapy with 19,200 impulses therapy across 8 weeks, we found an improvement of the IIEF-5 score, but it was not enough to be considered clinically significant. More studies are warranted before any recommendation on this topic.