bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance
Authors: Fittipaldi Antonela S , Hernández Julieta , Castrogiovanni Daniel , Lufrano Daniela , De Francesco Pablo N , Garrido Verónica , Vitaux Patrick , Fasano María Victoria , Fehrentz Jean-Alain , Fernández Adriana , Andreoli María F , Perello Mario 
Published: November 2019

Objective
The octanoylated peptide hormone ghrelin regulates appetite and glycaemic control. Des-acyl ghrelin abolishes some effects of ghrelin, but does not bind to ghrelin receptor. LEAP2 is a novel ligand for ghrelin receptor that blocks the effects of ghrelin. Some evidences show that plasma levels of these peptides are altered in adults with obesity, but their levels in childhood obesity remain poorly studied. Therefore, the objective of this study was to assess fasting plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with normoweight, overweight/obesity and their association with different anthropometric and metabolic variables.

Design
A total of 42 females and 40 males, ages 3–12 years old were enrolled as a cross-sectional cohort.

Results
Plasma levels of des-acyl ghrelin and LEAP2 (but not ghrelin) were lower and ghrelin/des-acyl ghrelin ratio was higher in children with overweight/obesity. Des-acyl ghrelin negatively correlated with age, BMI z-score, insulin and HOMA index, and the correlations were stronger in children with overweight/obesity. LEAP2 levels negatively correlated with BMI z-score. No gender differences were found.

Conclusions
Our findings suggest that ghrelin tone is increased in childhood obesity, due to a decrease on plasma levels of des-acyl ghrelin and LEAP2, and that des-acyl ghrelin is associated to insulin resistance, particularly in children with overweight/obesity.
Prolactin ≤1 ng/mL predicts macroprolactinoma reduction after cabergoline therapy
Authors: Kim Daham , Ku Cheol Ryong , Kim Kyungwon , Jung Hyein , Lee Eun Jig 
Published: November 2019

Objective
The association between prolactin level variation and prolactinoma size reduction remains unclear. This study aimed to determine the prolactin level cut-off predictive of a tumor size reduction.

Design
Retrospective cohort study.

Methods
We reviewed medical records of patients with prolactinoma who received primary cabergoline therapy and for whom complete data on pituitary hormone assays and sellar MRI at baseline and 3 months post treatment were available. We tested whether the certain prolactin level after 3 months post treatment predicted better response.

Results
Prolactin levels normalized in 109 (88.6%) of 123 included macroprolactinoma patients. The mean tumor size reduction was 22.9%, and patients in the lowest prolactin tertile (≤0.7) had the highest frequency of tumor size reductions of ≥20% (73.7 vs 52.9% and 45.9% in tertiles 2 (>0.7 to 2.6) and 3 (>2.6 to 20), P = 0.015). Patients with prolactin levels ≤1 ng/mL exhibited larger tumor size reductions vs those with prolactin levels of 1–20 (27.2 ± 18.3% vs 19.5 ± 13.9%, P = 0.014), 1–10 (19.3 ± 13.7%, P = 0.017) and 1–5 ng/mL (19.2 ± 14.3%, P = 0.039). A multivariable logistic regression analysis revealed that a prolactin level ≤1 ng/mL at 3 months and high-dose cabergoline therapy were significantly associated with tumor size reductions of ≥20% (odds ratio (OR): 2.8, 95% confidence interval (CI): 1.2–6.7, P = 0.017; OR: 2.0, 95% CI: 1.0–3.9, P = 0.043).

Conclusions
A prolactin level ≤1 ng/mL at 3 months after cabergoline treatment was correlated with a significant tumor size reduction in patients with macroprolactinoma. This finding may help clinical decision making when treating macroprolactinoma patients.
La violencia intrafamiliar en el desempeño laboral de las mujeres en el sector textil -confección
Authors: Quintero Arango Luis Fernando , Álvarez Agudelo Carlos Eduardo , Ibagon Parra Diana Marcela 
Published: November 2019

El objetivo principal de la investigación fue conocer los factores que se derivan de la violencia intrafamiliar y la incidencia en la productividad laboral en empresas del sector textil confección. Inicialmente, se realizó una revisión de la literatura, para luego desarrollar el proyecto investigativo bajo el paradigma interpretativo, haciendo énfasis, en identificar cómo el fenómeno de la violencia intrafamiliar impacta el desempeño laboral de las trabajadoras de este tipo de empresas. La metodología fue cualitativa, con un diseño transversal, y se utilizó la técnica de recolección de información por medio de un grupo focal y una entrevista semiestructurada con preguntas orientadoras. En los resultados se pudo constatar que la violencia intrafamiliar es un factor que incide en el bajo nivel de desempeño y productividad de las trabajadoras; donde el desempeño laboral se ve afectado por esta situación impactando la baja calidad en el trabajo. Así mismo, se estableció que las organizaciones no cuentan con una ruta de atención que ofrezca apoyo a las mujeres víctimas de la violencia intrafamiliar.
Occupational stress and evaluation of performance in university professors of the Departmento del Cesar, Colombia/Estrés Ocupacional Y Evaluación De Desempeño En Docentes Universitarios Del Departamento Del Cesar
Authors: Acosta Adriana Cristina , Ruiz Luz Karine Jimenez , Marin Miladys Redondo , Guerrero Edgar Guillermo Pulido 
Published: November 2019

This work analyzes the relation between occupational stress and the evaluation of teachers' performance. Due cultural reasons, both nationally and internationally, we spend a lot of time developing work activities and in our place of work, than in any other area. It increases the importance of evaluating and analyzing these circumstances, making possible the prevention and intervention in this type of cases. In this cross-sectional quantitative, cross-sectional study, we work with 47 teachers from a university in the Department of Cesar. The sociodemographic sheet and the stress survey of the technical annex of resolution 2646 of 2008, validated by Villalobos et al (2013), was applied; data about teacher´s performance evaluations 2016-2, was taken from the Registry and Control Office. The results indicate there is no significant association between the studied variables.
Journalistic quality in the treatment of gender-based violence against women: Caracol Noticias case/Calidad periodística en el tratamiento de la violencia de género contra las mujeres: el caso de Caracol Noticias
Authors: Mejía García Miguel Aviuth , Romero Claudia Beltrán , Marroquín Escalante Vanesa de Jesús 
Published: November 2019

Este artículo tuvo como propósito caracterizar el tratamiento periodístico en las noticias sobre violencia contra las mujeres por razones de género. Para una aproximación al objeto, se analizó Noticias Caracol, del Canal Caracol Televisión en Colombia. Para ello, se realizó un vaciado del contenido noticioso que emitió el canal sobre casos de violencia de género durante los años de 2013 y 2014 y que estuvieron accesibles a través del canal de YouTube del noticiero en mención. Como parte de los hallazgos se encontró una escasa presencia del tema en la agenda del noticiero y la baja importancia que se le ha dado al problema, como también se evidenció una ritualización en la presentación de los hechos, los protagonistas y las causas, aspectos que no contribuyen a que las audiencias vean críticamente las motivaciones del agresor y tampoco se genera conciencia crítica debido a la falta de fuentes expertas sobre esta violación sistemática de los Derechos Humanos.
Environmental Education and Education for Sustainability: history, fundamentals and/Educación Ambiental y Educaciòn para la Sostenibilidad: historia, fundamentos y tendencias.
Authors: Avendaño María Nay Valero , Febres Cordero-Briceño María Elena 
Published: November 2019

Los retos propuestos en el ámbito educativo en este siglo, demandan del educador una formación proactiva y autocrítica, lo que significa que éste debe utilizar diferentes caminos para aproximarse y comprender la dinámica ambiental con la que interactúa desde la complejidad. Unido a ello, el educador debe comprender los fundamentos y las tendencias de los tipos de Educación que emergieron entre 1970-2014, entre ellas:la Educación Ambiental(EA) yla Educaciónpara el Desarrollo Sostenible (EDS). En este contexto es oportuno preguntarnos: ¿serán tipos de educación que se bifurcan o se complementan?, ¿cuáles son los propósitos de cada una?, ¿qué aspectos teórico-metodológicos las caracterizan?,¿cuáles son los fundamentos y las tendencias pedagógicas que las sustentan? ¿cómo se han desarrollado en Venezuela? Para dar respuesta a estas interrogantes se desarrolló una investigación de carácter documental, con el propósito de analizar el recorrido histórico dela EAyla EDSen el marco de los lineamientos internacionales, sus fundamentos y tendencias. La metodología utilizada para la investigación fue el análisis de contenido, estableciendo cuatro categorías: conceptos clave, teorías implícitas y explicitas, paradigma y tendencias pedagógicas agrupadas en las dimensiones. Los resultados se organizaron siguiendo las técnicas de la descripción y el ordenamiento conceptual dela Teoría Fundamentada(Strauss y Corbin, 2002). Se obtienen como resultado el estado del arte dela EAy dela EDSen cuatro décadas, ambas se describen desde las propiedades que caracterizan las dimensiones: conceptual, institucional y pedagógica.
Initial Results from Mobile Low-Dose Computerized Tomographic Lung Cancer Screening Unit: Improved Outcomes for Underserved Populations
Authors: Raghavan Derek , Wheeler Mellisa , Doege Darcy , Doty John D. , Levy Henri , Dungan Kia A. , Davis Lauren M. , Robinson James M. , Kim Edward S. , Mileham Kathryn F. , Oliver James , Carrizosa Daniel 
Published: November 2019

Abstract

Introduction
The National Lung Screening Trial (NLST) demonstrated that screening high-risk patients with low-dose computed tomography (CT) of the chest reduces lung cancer mortality compared with screening with chest x-ray. Uninsured and Medicaid patients usually lack access to this hospital-based screening test because of geographic and socioeconomic factors. We hypothesized that a mobile screening unit would improve access and confer the benefits demonstrated by the NLST to this underserved group, which is most at risk of lung cancer deaths.

Patients and Methods
We created a mobile unit by building a Samsung BodyTom portable 32-slice low-dose CT scanner into a 35-foot coach; it delivers high-quality images for both soft tissue and bone and includes a waiting area and high-speed wireless internet connection for fast image transfer. The unit was extensively tested to show robustness and stability of mobile equipment. This project was designed to screen uninsured and underinsured patients, otherwise with eligibility criteria identical to that of the National Lung Screening Trial, with the only difference being exclusion of patients eligible for Medicare (which provides financial coverage for CT-based lung cancer screening).

Results
We screened 550 patients (20% black, 3% Hispanic, 70% rural) with a male-to-female ratio of 1.1:1, median age 61 years (range, 55–64), and found 12 lung cancers at initial screen (2.2%), including 6 at stage I–II (58% of total lung cancers early stage) and 38 Lung-RADS 4 (highly suspicious) lesions that are being followed closely. Incidental findings included nonlung cancers and coronary artery disease.

Discussion
In this initial pilot study, using the first mobile low-dose whole body CT screening unit in the U.S., the initial cancer detection rate is comparable to that reported in the NLST, despite excluding patients over the age of 64 years who have Medicare coverage, but with marked improvement of screening rates specifically in underserved sociodemographic, racial, and ethnic groups and with better outcomes than conventionally found in the underserved and at lower cost per case.

Implications for Practice
This study shows clearly that a mobile low-dose CT scanning unit allows effective lung cancer screening for underserved populations, such as impoverished African Americans, Hispanics, Native Americans, or isolated rural groups, and has a pick-up rate of 1% for early stage disease. If confirmed in a planned randomized trial, this will be policy changing, as these groups usually present with advanced disease; this approach will produce better survival data at lower cost per case.
Bacteria and yeast isolation and characterisation from a South African fermented beverage
Authors: Moodley Sanchia S. , Dlamini Nomusa R. , Steenkamp Lucia , Buys Elna 
Published: November 2019

Spontaneous fermentation of motoho, a southern African non-alcoholic sorghum beverage, results in products with inconsistent microbiological and sensory quality. We aimed to identify the microorganisms involved in the fermentation of motoho by using culture-dependent techniques as well as culture-independent polymerase chain reaction (PCR) screening and matrix-assisted laser desorption/ionisation time-of-flight analysis (MALDI-TOF). Lactobacillus, Candida, Rhodotorula and Geotrichum species were identified. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) was used to evaluate the protein profiles of the isolated Lactobacillus species which produced protein bands of 14 kDa to 160 kDa, similar to those of other lactic acid bacteria isolated from various foods. A sensory panel evaluated and found significant differences (p<0.05) between the mouth feel, aroma and flavour of the traditional and modified motoho, with the latter being preferred. The microorganisms identified in this study could be used as starter cultures to optimise upscaled production of motoho.
Significance:

Traditionally fermented products have variable quality and the microorganisms isolated in this study could be used to decrease the variability in this fermented sorghum beverage.
Examination cheating: Risks to the quality and integrity of higher education
Authors: Baijnath Narend , Singh Divya 
Published: November 2019

We examine the exigencies and impact of examination cheating, focusing specifically on the prevalence and risk of cheating taking place in examination venues. We document the problem with global coverage and note the consistency of the scourge and highlight the different approaches of institutions to dealing with the risk. Stressing the prejudice arising from examination cheating to both universities specifically and society generally, one of the root causes of the risk, namely the moral compass and ethical norms of university students and the societies in which they function, is discussed. The innovation of students when working out cheating practices and the facilitating effects of technology are considered as a backdrop to exemplars of good practices that have been implemented to mitigate the reality and risk of examination fraud. Recognising examination cheating as a fraud on society and a critical risk to university reputation, we question whether university leadership recognises the risk and gives it adequate (and responsible) emphasis in strategic and operational organisational risk identification and management.
Significance:

Cheating in examinations, and especially in the examination venue, is a global scourge. A comparison of global good practices is presented which provides a framework for institutional discussion to begin to address and transparently deal with the issues and impact of examination cheating.
Acknowledging technology as one of the significant enablers of examination fraud and noting the constraints confronting universities, there is nevertheless a critical need for institutions to mitigate the risk. In not doing so, universities, which are fundamentally supported by the fiscus and public taxpayers, are committing a fraud on society.
The attitude of some students and academic staff, as well as public perceptions to examination cheating raise the lid on a moral decay that is beginning to manifest in society globally.
Universities are challenged to address the issue of examination cheating proactively, openly and honestly. The repercussions of failing to do so are highlighted and exemplars are provided of what can and has already been tried and tested to mitigate the risks.
Assessment, plagiarism and its effect on academic integrity: Experiences of academics at a university in South Africa
Authors: Mahabeer Pryah , Pirtheepal Tashmika 
Published: November 2019

The quality of teaching, learning and assessment is compromised by the growing problem of academic dishonesty, especially in large class sizes as a result of the ‘massification’ of education. In South Africa and around the world, student plagiarism and cheating has become a matter of concern, especially when it comes to teaching large classes. This concern has received much attention as it impacts negatively on the maintenance of academic standards and integrity at many universities. Academics have a major role to play in the process of maintaining academic integrity. Through an ‘interpretivist’ and qualitative approach, we explored the experiences of three emerging academics within the Discipline of Curriculum Studies at a university in South Africa. We used Pinar’s method of currere as a lens that focuses on academics’ experiences of assessment and plagiarism in teaching large classes and its effect on academic integrity. The findings suggest that although ‘massification’ of education in South Africa is commended for addressing past social injustices and for facilitating accessibility to education, quality teaching and learning including assessment is seriously compromised. This demands a serious rethink of assessment strategies to deter academic dishonesty, and a reconsideration of the way academics and institutions think about plagiarism detection tools in teaching large classes.
Significance:

Understanding academics’ experiences of assessment and addressing the growing problem of plagiarism can contribute significantly to efforts towards improving teaching and assessment practices in large classes, and to upholding academic honesty within higher education institutions in South Africa.
A rethink of effective assessment strategies is needed to provide a worthwhile quality educational experience. In the context of this study, ethics within the teacher education curriculum should be prioritised.
IMPLEMENTATION OF POLYCHRONICITY BEHAVIOR IN FRONTLINE EMPLOYEES PT. TAMAN WISATA CANDI BOROBUDUR
Authors: Andriani Rian , Sembiring Nur Hawai 
Published: November 2019

ABSTRAKCandi Borobudur merupakan candi atau kuil Buddha terbesar di dunia berbentuk tumpukan stupa dengan tinggi 42 meter dan memiliki relief dengan panjang lebih dari 1 kilometer yang terletak di Kota Magelang, provinsi Jawa Tengah yang dikelola oleh PT. Taman Wisata Candi Borobudur. Candi Borobudur tidak hanya menjadi tempat ibadah namun menjadi tempat wisata sejarah yang di kelola oleh PT. Taman wisata Candi Borobudur, Prambanan dan Ratu Boko. Faktor tersebut yang menuntut manajemen Candi Borobudur untuk memberikan service excellent kepada pengunjung, terutama pada divisi frontline yang berinteraksi langsung dengan pengunjung. Upaya memaksimalkan faktor service exellent melalui karyawan frontline dapat dilaksanakan dengan memiliki polychronicity behavior. Peneliti menggunakan metode penelitian kualitatif deskriptif dalam penelitian ini untuk mengetahui efektivitas polychronicity behavior dalam meningkatkan kualitas service exellent. Melalui observasi yang mendalam, peneliti mendapatkan hasil temuan bahwa sebagian besar karyawan Frontline mampu menjalankan polychronicity behavior. Kendala utama dalam pelaksanaan polychronicity behavior adalah faktor usia dan tingkat pendidikan karyawan frontline. Kata Kunci: polychronicity behavior, karyawan frontline, candi Borobudur IMPLEMENTATION OF POLYCHRONICITY BEHAVIOR IN FRONTLINE EMPLOYEES PT. TAMAN WISATA CANDI BOROBUDUR ABSTRACTBorobudur Temple is the largest Buddhist temple in the world in the form of a pile of 42 meters high stupa and more than 1 kilometer long relief located in the city of Magelang, Central Java province. Borobudur Temple is not only a place of worship but a historical tourist place managed by PT. Borobudur Temple tourism park, besides Prambanan and Ratu Boko. This factor demands the management of Borobudur Temple to provide excellent service to visitors, especially in the frontline division that interacts directly with visitors. Efforts to maximize exellent service factors through frontline employees can be implemented by having a polychronicity behavior. The researcher used descriptive qualitative research methods in this study to determine the effectiveness of polychronicity behavior in improving exellent service quality. Through in-depth observation, the researchers obtained findings that most Frontline employees were able to carry out polychronicity behavior. The main obstacle in the implementation of the polychronicity behavior is the age and education level of frontline employees.Keywords: polychronicity behavior, frontline employees, Borobudur temple
PERBEDAAN CUSTOMER SERVICE EXPERIENCE PADA GENERASI Y DAN GENERASI Z DALAM MELAKUKAN PEMESANAN ONLINE FOOD DELIVERY MELALUI APLIKASI GO-FOOD
Authors: Wijaya Viany Revita , Warouw Grace Irene , Thio Sienny 
Published: November 2019

ABSTRAKPenelitian ini bertujuan untuk mengetahui customer service experience dari generasi Y dan generasi Z serta melihat apakah terdapat perbedaan pada dua generasi tersebut dalam melakukan pemesanan online food delivery melalui aplikasi GO-FOOD yang dilihat dari faktor psikologis dan faktor fungsional. Penelitian kuantitatif digunakan dalam penelitian ini dengan menyebarkan kuesioner kepada 145 responden generasi Y dan 128 responden generasi Z di Surabaya. Selanjutnya, data diolah dengan menggunakan analisa statistik deskriptif dan independent sample t-test untuk mengetahui apakah terdapat perbedaan signifikan dari dua generasi tersebut dalam melakukan pemesanan makanan secara online. Hasil penelitian menunjukkan bahwa hanya “trust” dan “value for money” yang merupakan sub-variabel dari faktor psikologis yang memiliki perbedaan yang signifikan antara generasi Y dan Z. Kata Kunci : Customer service experience, generasi Y, generasi Z, online food delivery. DIFFERENCES IN CUSTOMER SERVICE EXPERIENCE BETWEEN GENERATION Y AND GENERATION Z IN ORDERING FOOD SERVICE DELIVERY USING GO-FOOD APPLICATION ABSTRACTThis research aims to investigate customer service experience of generation Y and generation Z and to examine differences between the two generations in ordering online food delivery using GO-FOOD application from the perspective of psychological dan functionality factor. Quantitative research was employed in this paper by distributing questionnaires to 145 respondents of generation Y and 128 respondents of generation Z in Surabaya. Then, data was processed using descriptive statistics analysis and independent sample t-test in order to investigate whether there is a significance difference between the two generations in ordering online food delivery. The result of this research shows that only “trust” and “value for money” which are sub-variables of psychological factor have significantly difference between generation Y and generation Z.Keywords : Customer service experience, online food delivery, x generation, y generation