bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competencies for a healthy physically active lifestyle: Second-order analysis and multidimensional scaling
Authors: Carl Johannes , Sudeck Gorden , Pfeifer Klaus 
Published: May 2020

Abstract
The model of physical activity-related health competence (PAHCO) assumes that individuals require movement competence, control competence, and self-regulation competence to lead a healthy, physically active lifestyle. Although previous research has already established some measurement factors (n = 8) of the three dimensions, no attempts have so far been made to statistically aggregate them on the sub-competence level. Therefore, the goal of the present study was to test two additional factors for PAHCO and subsequently model the second-order structure with two samples from the fields of rehabilitation and prevention. We conducted two questionnaire surveys with persons with multiple sclerosis (n = 475) and teaching students undergoing a basic qualification course in physical education (n = 502). After performing exploratory items analysis, we used second-order confirmatory factor analysis (CFA) and multidimensional scaling to investigate whether the scales could be bundled in accordance with the PAHCO model. The CFAs with ten factors (42 items) demonstrated a good model fit. In contrast, the second-order analysis with a simple loading structure on the three sub-competencies revealed an unacceptable model fit. Instead, a second-order model variant was preferred (CFI = 0.926, RMSEA = 0.048, SRMR = 0.065) in which body awareness and self-efficacy had theory-conform cross-loadings. The results of multidimensional scaling (two-dimensional solution) were in line with the extracted second-order structure. The present results suggested that the extension of the measurement instrument to ten first-order factors was psychometrically justified. The results from the second-order analyses provided the basis for the creation of sum scores, representing manifest indicators of movement competence, control competence, and self-regulation competence. Future studies are needed that relate the sub-competencies of PAHCO to indicators of health-enhancing physical activity in relevant target Groups.
The impact of asymptomatic individuals on the strength of public health interventions to prevent the second outbreak of COVID-19
Authors: Wang Xiaochen , Wang Shengfeng , Lan Yueheng , Tao Xiaofeng , Xiao Jinghua 
Published: May 2020

Abstract
The pandemic of coronavirus disease 2019(COVID-19) has threatened the social and economic structure all around the world. Generally, COVID-19 has three possible transmission routes, including pre-symptomatic, symptomatic, and asymptomatic transmission, among which the last one has brought a severe challenge for the containment of the disease. One core scientific question is to understand the influence of asymptomatic individuals and of the strength of control measures on the evolution of the disease, particularly on a second outbreak of the disease. To explore these issues, we proposed a novel compartmental model that takes the infection of asymptomatic individuals into account. We get the relationship between asymptomatic individuals and critical strength of control measures theoretically. Furthermore, we verify the reliability of our model and the accuracy of the theoretical analysis by using the real confirmed cases of COVID-19 contamination. Our results, showing the importance of the asymptomatic population on the control measures, would provide useful theoretical reference to the policymakers and fuel future studies of COVID-19.
Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis
Authors: Gao Yi-jie , Ye Lei , Zhang Jia-shuo , Yin Yang-xue , Liu Min , Yu Hong-biao , Zhou Rong 
Published: May 2020

Abstract
Background: COVID-19 outbreak in Wuhan, China recently. It quickly spread throughout worldwide. In this study, we systematically reviewed the clinical features and outcomes of pregnant women with COVID-19.Methods: PubMed、Web of Science、EMBASE、MEDLINE were searched from January 1, 2020 to April 16, 2020. Case review of pregnant women infected with COVID-19 were included. Two reviewers screened 366 literatures and 14 studies included, four reviewers independently extracted the features of the literatures. We used random-effects model to analyze incidence (P) and 95% confidence interval (95%CI). Heterogeneity was assessed using the I2 statistic.Results: The meta- analysis included 236 pregnant women with COVID-19. The results were as follows: positive CT findings (71%; 95%CI, 0.49~0.93), cesarean section (65%; 95%CI, 0.42~0.87), fever (51%; 95%CI, 0.35~0.67), lymphopenia (49%; 95%CI, 0.29~0.70), coexisting disorders (33%; 95%CI, 0.21~0.44), cough (31%; 95%CI, 0.23~0.39), fetal distress (29%; 95%CI, 0.08~0.49), preterm labor (23%; 95%CI, 0.14~0.32), severe case or death (12%; 95%CI, 0.03~0.20). The subgroup analysis showed compared with nonpregnant patients, pregnant women with COVID-19 had significantly lower incidences of fever (pregnant women group, 51%; nonpregnant patients group, 91%; P＜0.00001) and cough (pregnant women group, 31%; nonpregnant patients group, 67%; P＜0.0001). Conclusions: The incidence of fever, cough and positive CT findings in pregnant women with COVID-19 is less than that in the general population, preterm labor is the opposite. There is no evidence that COVID-19 can propagate vertically for the time being.
Coronavirus herd immunity&nbsp;optimizer (CHIO)
Authors: Al-Betar Mohammed Azmi , Alyasseri Zaid Abdi Alkareem , Awadallah Mohammed A. , Doush Iyad Abu 
Published: May 2020

Abstract
In this paper, a new nature-inspired human-based optimization algorithm is proposed which called Coronavirus Herd Immunity Optimizer (CHIO). The inspiration of CHIO is originated from the herd immunity concept as a way to tackle coronavirus pandemic (COVID-19). The speed of spreading coronavirus infection depends on how the infected individuals directly contact with other society members. In order to protect other members of society from the disease social distancing is suggested by health experts. Herd immunity is a state the population reach when most of the population is immune which results in the prevention of disease transmission. These concepts are modeled in terms of optimization concepts. CHIO mimics the herd immunity strategy as well as the social distancing concepts. Three types of individual cases are utilized for herd immunity: susceptible, infected, and immuned. This is to determine how the newly generated solution updates its genes with social distancing strategies. CHIO is evaluated using 23 well-known benchmark functions. Initially, the sensitivity of CHIO to its parameters is studied. Thereafter, the comparative evaluation against seven state-of-the-art methods is conducted. The comparative analysis verifies that CHIO is able to yield very competitive results compared to those obtained by other well-established methods. In conclusion, CHIO is a very powerful optimization algorithm that can be used to tackle many optimization problems across a wide variety of optimization domains.
COVID-19 in Elderly Patient: A Case Report
Authors: Qin Zheng , Wang Xingjian , Wang Wei 
Published: May 2020

Abstract
Background: Coronavirus Disease 2019 (COVID-19) outbroke in Wuhan, China in December 2019 and spread rapidly. Elderly patients with COVID-19 are more likely to develop into severe type, but little related experience has been introduced. Case presentation: An 82-year-old female patient living in Wuhan, China was referred because of fever, dry cough and chest distress for a week. Clinical diagnosis of COVID-19 was considered, confirmed by viral nucleic acid detection. For her poor nutritional status and deteriorated hypoalbuminemia, intact protein enteral nutrition powder was added and albumin was supplemented besides the antiviral therapy. Her fever gradually subsided with the alleviation of related symptoms. During her hospitalization, D-dimer level elevated with ultrasonographically detected thromboembolism in bilateral gastrocnemius veins, and low molecular weight heparin was thereby administrated for the prevention of pulmonary embolism. Conclusions: The experience of this case suggested that the timely screening and intervention of malnutrition and venous thromboembolism are crucial issues to be concerned when treating elderly patients with severe COVID-19 besides the routine antiviral therapy.
ASSESSMENT OF BUSINESS PROCESS MANAGEMENT FOR MSMEs IN EAST JAVA
Authors: Chotijah Umi 
Published: May 2020

The role of micro, small and medium enterprises (MSME) for the economy of many countries, especially Indonesia are very important. The garment industry is one of the developing industries in Indonesia. Enterprises need to understanding, documenting, modelling, analyzing, simulating, implementing to increasing the value and achieving business operational efficiency and survive business competition. Therefore, it is necessary to know assess the maturity level of business process management in MSMEs. The purpose of this study is to assess the maturity level of business process management from MSMEs. First, the relevant literature is reviewed to gain insight into the practice of business process management in general, the context of MSME in Indonesia and previous studies related to business process management in the context of MSMEs. This research was conducted in East Java and data collection was done by distributing questionnaires to MSME owners. This study shows that a lack of knowledge resources about BPM is the main factor causes the MSMEs have low business process maturity level.
Novel Insights on the Role of the Human Sperm Proteome
Authors: Cannarella Rossella , Condorelli Rosita A. , Calogero Aldo E. , La Vignera Sandro 
Published: May 2020

The spermatozoon has classically been seen only as a paternal DNA transporter into the oocyte, thus underestimating the entire contribution of the male gamete to the embryo development. The advancement of the research supports that not only the sperm genome, but the entire sperm transcriptome and proteome carry crucial information for fertilization and embryo development.Altogether, 6871 proteins have been reported in spermatozoa so far. Their functional analysis has recently addressed to the sperm proteome a role in fertilization, preimplantation embryo development and paternal epigenetic inheritance. Targeted analysis of human spermatozoa is warranted to compile an evidence-based list of sperm-carried molecular targets in infertile patients.
Evaluation of Changes in the Expression Profile of mRNA and Proteinencoding Adiponectin in Ishikawa Cell Line under the Influence of Cisplatin – Preliminary Report
Authors: Kiełabsiński Robert , Kieszkowski Przemysław , Grabarek Beniamin O. , Boroń Dariusz 
Published: May 2020

Background:
A reduced concentration of adiponectin is considered as an independent factor
of the risk of inducing endometrial cancer. Cisplatin is a drug used in the therapy of this type of neoplasm.
However, knowledge of the effects of cisplatin on the adiponectin level is still limited.

Objective:
he purpose of this study was to assess the impact of cisplatin depending on the concentration
and time of exposition of the cells to the drug on the adiponectin level in the endometrial cancer
cell line.

Methods:
: Cells of endometrial cancer cell line Ishikawa were exposed for 12,24 and 48 hour periods to
cisplatin with the following concentrations: 2.5μM, 5μM, 10μM. The changes in the expression profile
of adiponectin were compared to the RtqPCR reaction and ELISA test. The STATISTICA 13.0 PL
program was used for statistical analysis (p<0.05).

Results:
: In the culture without the drug, the concentration of adiponectin was statistically lower than in
the cell culture incubated with the drug. Changes on the mRNA level seem to be more specific than on
the protein level, although in both cases, the same trend in the expression changes was noted.

Discussion:
The longer the time of exposition of the cells to the drug, the expression of mRNA, and
the adiponectin protein increased. Changes in the expression profile were characterized statistically
(p<0.05).

Conclusion:
Cisplatin, in a noticeable way, changes the expression profile of adiponectin. Molecular
analysis indicated that in the case of endometrial cancer therapy should be implemented with a concentration
of no less than 5 μM.
Physical Activity and Body Mass Index in Relation to Infertility in Women
Authors: Kaneda Chieko , Kanejima Yuji , Kitamura Masahiro , Izawa Kazuhiro P. 
Published: May 2020

Background:
Infertility is a global social issue, and reproductive health is a priority in
global health. This review aimed to study the relation between physical activity (PA) and infertility
in non-obese or non-overweight women.

Methods:
We used search strategies in the National Library of Medicine database including the
PubMed database to October 2019 to find articles related to women and fertility, infertility, exercise,
PA, pregnancy rate, live births, fecundability, and conception. Only cohort studies or randomized
controlled trials in English were chosen for review that included outcomes directly related
to becoming pregnant. We selected studies in which the participants were categorized by low or
high body mass index (BMI).

Results:
We found 6 papers meeting our criteria. In the association between PA and outcome, vigorous
PA in women with low BMI resulted in both positive and negative effects that were weaker
than those in women with high BMI. Among women with low BMI, moderate PA was weakly but
positively associated with outcome whereas walking was not.

Conclusion:
We observed some trends and a slight difference between the outcomes of women
with low versus high BMI. There are only a few studies on infertile women with low BMI, and further
investigation is warranted.
Antidyslipidemic and Antioxidant Activities of Matricaria pubescens (Desf.) Shultz. in Streptozotocin-Induced Diabetic Rats
Authors: Amssayef Ayoub , Azzaoui Bouchra El , Ajebli Mohammed , Eddouks Mohamed 
Published: May 2020

Aims:The study aimed to evaluate the antihyperlipidemic and antioxidant activities of Matricaria pubescens.Background:Matricaria pubescens (Desf.) Shultz belongs to Asteraceae family and it is commonly used traditionally for handling diabetes mellitus.Objective:The objective of this study was to assess the antioxidant activity of Matricaria pubescens (Desf.) Shultz and its effect on lipid and lipoprotein profile in normal and streptozotocin-induced diabetic rats.Methods:The effect of repeated (7 days of treatment) oral administration of the aqueous extracts of aerial part of Matricaria pubescens (MPAE) at a dose of 40 mg/kg on lipid and lipoprotein profile was examined in normal and streptozotocin-induced diabetic rats. Furthermore, a preliminary phytochemical screening and the quantification of phenolic, flavonoid and tannin contents as well as the antioxidant activity using two methods (FRAP and ABTS) were carried out.Results:MPAE demonstrated a potent antidyslipidemic effect in diabetic rats by reducing serum levels of triglycerides, total cholesterol and Low-Density Lipoprotein (LDL). In addition, the results showed that the extract is rich in several phytochemical compounds and revealed an important antioxidant activity.Conclusion:In summary, this study proved that Matricaria pubescens (Desf.) Shultz. has a favorable effect on diabetic dyslipidemia.
Peranan Otoritas Jasa Keuangan (OJK) Sebagai Lembaga Muhtasib Dalam Industri Keuangan Syariah di Indonesia
Authors: Salam Abdul , Irsyad Syaiful Muhammad 
Published: May 2020

<p>In Indonesia, one of the institutions that can be considered a Muhtasib institution in the sharia financial sector is the Financial Services Authority (OJK). As Law Number 21 of 2011, the OJK has the function of organizing an integrated system of regulation and supervision of all activities in the financial services sector which include financial service activities in the Banking sector; financial service activities in the Capital Market sector; and financial service activities in the Insurance, Pension Funds, Financing Institutions and Other Financial Services Institutions sectors, including the Islamic finance industry sector. This study will unravel the extent of the role of the FSA as the Muhtasib in the Islamic finance industry in Indonesia, especially in the regional areas of Central Java and D.I. Yogyakarta.</p><p>This research did 2 (two) kinds of research, they are field of study and literature study. The collecting data of this research through observation and non-structured interview. The methode of data collection is conducting interviews with the Central Java OJK, OJK D.I. Yogyakarta.</p><p>The conclusion of this study is that the role of the Financial Services Authority (OJK) in Regional Region 3 of Central Java and Yogyakarta as a Muhtasib institution in supervising the Islamic financial industry in Central Java and Yogyakarta is quite significant, although with some notes, including the position of OJK Regional 3 Central Java and DIY Yogyakarta which is only able to reach Islamic financial institutions (LKS) whose head office is located in Central Java and Yogyakarta, while LKS only has branch offices in Central Java and Yogyakarta Yogyakarta. Is the authority of the Regional OJK 3 of Central Java and DIYogyakarta, meaning that it is the domain of the authority of the Central OJK in Jakarta. The problem is if there is a violation or an act that is against the law, then the Regional OJK 3 of Central Java and D.I. Yogyakarta is only reporting or coordinating with the Central OJK. The Financial Services Authority (OJK) in Region 3 of Central Java and Yogyakarta Yogyakarta has carried out its function as an actress in the context of violations of law or criminal acts, in which the OJK has played a function as an investigator and then reported to law enforcement officials (APH ) and submitted to the judicial process. However, related to the implementation of the Microfinance Institution Law, OJK has not been able to carry out its function as a constitutional acter in enforcing Article 39 of the LKM Law regarding the existence of BMTs in the community which should abide and comply with licensing regulations under the OJK</p><p><strong>Keywords:</strong><strong> </strong><strong>Financial Services Authority, Muhtasib Institution, Sharia Financial Industry</strong></p>
Prediction Model for Timing of Death in Potential Donors After Circulatory Death (DCD III): Protocol for a Multicenter Prospective Observational Cohort Study
Authors: Kotsopoulos Angela M M , Vos Piet , Jansen Nichon E , Bronkhorst Ewald M , van der Hoeven Johannes G , Abdo Wilson F 
Published: May 2020

Background
Controlled donation after circulatory death (cDCD) is a major source of organs for transplantation. A potential cDCD donor poses considerable challenges in terms of identification of those dying within the predefined time frame of warm ischemia after withdrawal of life-sustaining treatment (WLST) to circulatory arrest. Several attempts have been made to develop models predicting the time between treatment withdrawal and circulatory arrest. This time window determines whether organ donation can occur and influences the quality of the donated organs. However, the selected patients used for these models were not always restricted to potential cDCD donors (eg, patients with cancer or severe infections were also included). This severely limits the generalizability of those data.

Objective
The objectives of this study are the following: (1) to develop a model predicting time to death within 60 minutes in potential cDCD patients; (2) to validate and update previous prediction models on time to death after WLST; (3) to determine timing and patient characteristics that are associated with prognostication and the decision-making process that leads to initiating end-of-life care; (4) to evaluate the impact of timing of family approach on organ donation approval; and (5) to assess the influence of variation in WLST processes on postmortem organ donor potential and actual postmortem organ donors.

Methods
In this multicenter observational prospective cohort study, all patients admitted to the intensive care unit of 3 university hospitals and 3 teaching hospitals who met the criteria of the cDCD protocol as defined by the Dutch Transplant Foundation were included. The target of enrolment was set to 400 patients. Previously developed models will be refitted in our data set. To further update previous prediction models, we will apply least absolute shrinkage and selection operator (LASSO) as a tool for efficient variable selection to develop the multivariable logistic regression model.

Results
This protocol was funded in August 2014 by the Dutch Transplant Foundation. We expect to have the results of this study in July 2020. Patient enrolment was completed in July 2018 and data collection was completed in April 2020.

Conclusions
This study will provide a robust multimodal prediction model, based on clinical and physiological parameters, that can predict time to circulatory arrest in cDCD donors. In addition, it will add valuable insight in the process of WLST in cDCD donors and will fill an important knowledge gap in this essential field of health care.

Trial Registration
ClinicalTrials.gov NCT04123275; https://clinicaltrials.gov/ct2/show/NCT04123275

International Registered Report Identifier (IRRID)
DERR1-10.2196/16733