bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penile Fracture in Spinal Cord Injury Patient: A Rare Case Report
Authors: Hutajulu Yosua Yerico , Hengky Antoninus , Tritanto Rio , Gouw Tiono Budi 
Published: December 2024

Abstract

Background
Penile fracture is a urological emergency. Penile fracture is rare, with an incidence of 1 in 175,000 men.
Case Presentation
A 35-year-old man came to the ER shortly after experiencing swelling and bruising of his penis during sexual activity. The patient had a history of spinal cord injury nine years prior. The patient experienced paraparesis and hypoesthesia below L1 and sacral sparing. He expressed discomfort in the penis rather than pain. Physical examination revealed diffuse swelling, right-sided angulation, and a penile hematoma. The patient underwent surgery 14 hours after admission. The patient had no postoperative complaints, regained the ability to achieve erections, and showed no early signs of complications.
Conclusion
In penile fracture patients with SCI, severe pain may be absent. Therefore, a thorough evaluation through detailed history-taking and physical examination is crucial. Prompt surgical intervention resulted in successful functional restoration without complications.
Intraprocedural O-arm Computed Tomography guided Navigation with Ventilatory Strategy for Atelectasis Electromagnetic Navigation Bronchoscopic Biopsy of Peripheral Lung Lesions: an IDEAL stage 2a study
Authors: Dai Shaohua , Xu Guoqiu , Tang Jian 
Published: December 2024

Abstract

Background: To improve the accuracy of electromagnetic navigation bronchoscopy (ENB) in the diagnosis of pulmonary nodules, we developed an innovative method to modify ENB, which first combines Intraprocedural Computed tomography (CT) guided navigation with Ventilatory strategy for Atelectasis (ICNVA).
Methods: This was a retrospective single-institution study in alignment with the IDEAL (Idea, Development, Exploration, Assessment, Long-term follow-up) 's prescribed developmental stages 2a. Patients who planned to undergo ENB for pulmonary lesion biopsy were invited to participate. For each patient, we do not use preoperative chest CT data in the conventional ENB approach for navigation planning. Instead, after endotracheal intubation under general anesthesia and bronchoscope insertion into the endotracheal tube, we used O-arm CT scanner in the hybrid operating room to acquire intraoperative CT data for ENB path planning. Following endotracheal intubation under general anesthesia, a ventilation strategy to prevent lung collapse is employed to reduce the occurrence of atelectasis. Moreover, the same ventilation parameters were used when intraoperative CT data was acquired and ENB procedures was performed to minimize computed tomography to body divergence (CTBD) to the greatest extent possible. 50 consecutive participants completed this study beginning in March 2022. We have iteratively adjusted the technology. In accordance with the IDEAL recommendations, we recorded the technological modifications and general characteristics of each patient and ENB related data.
Results: All patients completed biopsy successfully. 2 patients developed pneumothorax, and 2 patients experienced bleeding but did not require surgical treatment. Four deliberate changes in technique occurred. After the first technological modification, ENB related security improved. After starting to establish puncture tunneling by using Wang's needle (MW-319), the ENB accuracy was significantly improved. After the CT scan area was reduced, the radiation dose to patients was reduced.
Conclusions: ICNVA-ENB has early indications for safety and efficacy in the biopsy of peripheral lung lesions.
Effect of Low-dose Esketamine on Postoperative Recovery Quality in Patients Undergoing Total Laparoscopic Hysterectomy: A Randomized Controlled Trial
Authors: Zhang Jing , Niu Zheng , Wang Ting , Yu Lianya , Ren Xinyi , Zhang Shurui , Zhu Yuwei , Qi Dunyi 
Published: December 2024

Abstract

Purpose
To investigate the effect of intraoperative low-dose esketamine infusion on postoperative quality of recovery in patients undergoing total laparoscopic hysterectomy.
Patients and methods:
A total of 106 female patients scheduled for elective total laparoscopic hysterectomy were randomly divided into group P (saline group) and group S (esketamine group). Group P received induction with normal saline, propofol, sufentanil, midazolam, and rocuronium, while group S received induction with low-dose esketamine (0.25 mg/kg), propofol, sufentanil, midazolam, and rocuronium. Both groups were maintained with intravenous infusion of propofol and remifentanil. The quality of recovery (QoR-40), Numerical Rating Scale (NRS), and Pittsburgh Sleep Index (PSQI) scores were assessed at 8, 24, 48, 72 hours, 7 days, and 30 days post-surgery. Hamilton Depression Scale (HAMD) scores were evaluated at 72 hours, 7 days, and 30 days post-surgery. Intraoperative hemodynamics, remifentanil consumption, total surgical cost, inflammatory reactions, and adverse reactions were also documented.
Results
Both groups had similar QoR-40 scores at each time point (P > 0.05). Patients in group S had less intraoperative remifentanil use (P < 0.001), less consumption of phenylephrine (P = 0.005), fewer episodes of hypotension (P < 0.001), and shorter extubation and PACU residence times (P < 0.001). The NRS scores after extubation (P = 0.007), 8 hours (P = 0.027), and 48 hours (P = 0.016) after surgery, and the postoperative NLR (P = 0.003), and postoperative 24-h PSQI score (P = 0.024) were significantly lower in group S. The MBP was higher at T3 (P < 0.001), and the HR was faster at T1 (P = 0.005), T3 (P = 0.023), T4 (P = 0.014) and T5 (P = 0.010) in group S. Multiple linear regression analyses demonstrated that educational attainment was associated with postoperative recovery (P < 0.05).
Conclusion
In patients undergoing total laparoscopic hysterectomy, the use of low-dose esketamine did not affect QoR-40 scores for overall postoperative recovery. However, it resulted in improved maintenance of intraoperative hemodynamics, decreased intraoperative opioid requirements, shortened postoperative extubation and PACU dwell time, and alleviated postoperative inflammatory response and pain, without introducing additional adverse effects.
The impact of stratified management of Ki-67 on the prognosis of small-cell lung cancer
Authors: Zhang Xiaofang , He Mingyang , Zheng Guanghua , Bai Junjun 
Published: December 2024

Abstract

Objective
The Ki-67 protein is frequently employed in pathological immunohistochemistry to indicate cell proliferation activity. The principal aim of this study was to examine the impact of stratified management of Ki-67 on the clinicopathological characteristics and prognosis of patients with small-cell lung cancer (SCLC).
Methods
A total of 175 patients with SCLC who underwent surgical treatment were included in the study, with available data on the results of postoperative immunohistochemistry of the Ki-67 protein. A retrospective analysis was conducted to investigate the correlation between the protein and various clinicopathological features of SCLC, as well as its impact on survival.
Results
The cut-off value for the Ki-67 level was determined to be 75% through receiver operating characteristic (ROC) analysis. An elevated Ki-67 level was found to be associated with preoperative chemotherapy (χ2 = 4.980, P = 0.028), preoperative radiotherapy (χ2 = 4.600, P = 0.032), T stage (χ2 = 4.173, P = 0.041), TNM staging (χ2 = 10.4, P = 0.005), and lymph node involvement (χ2 = 16.721, P < 0.0001). The results of the survival analysis indicated that patients with SCLC exhibiting high levels of Ki-67 had a poorer prognosis than those with low Ki-67 levels (P = 0.0004). This was particularly evident in patients aged 60 years or older (P = 0.034), in males (P = 0.046), smoking for a minimum of 30 years (P < 0.001), advanced T staging (T3 + T4) (P = 0.031), lymph node involvement (P = 0.038), and TNM staging (P = 0.015), were associated with poorer outcomes. The univariate Cox regression analysis indicated that exposure to tobacco consumption (P = 0.005), gender (P = 0.003), pathologic T stage (P = 0.047), lymph node metastasis (P = 0.035), TNM staging (P = 0.012), and Ki-67 positive rate (P < 0.001) were the factors related to prognosis in SCLC. The results of the multivariate regression analysis indicated that gender (HR: 0.161, 95% CI: 0.058–0.449, P = 0.000), higher Ki-67 positive rate ((HR: 1.045, 95%CI: 1.025–1.510, P < 0.001), lymph node metastasis(HR: 0.326, 95%CI: 0.161–0.661, P = 0.002), and pathologic T stage (HR: 0.319, 95%CI: 0.120–0.850, P = 0.022) was identified as an additional risk factor for SCLC-related mortality.
Conclusion
In summary, the Ki-67 protein is not only strongly associated with the malignant characteristics of SCLC, but also the stratification of Ki-67 has significant implications for the treatment and prognosis of patients with small-cell lung cancer.
Intensified dominance of El Niño-like convection relevant for global atmospheric circulation variations
Authors: Lin Shuheng , Cai Fenying , Gerten Dieter , Yang Song , Jiang Xingwen , Su Zhen , Kurths Juergen 
Published: December 2024

Abstract

Tropical convection anomaly could serve as a crucial driver of global atmospheric teleconnections and weather extremes around the world. However, quantifying the dominances of convection anomalies with regional discrepancies, relevant for the variations of global atmospheric circulations, remains challenging. By using a network analysis of observation-based CMAP rainfall and ERA5 reanalysis datasets, our study reveals that El Niño-like convection is the most primary rainfall pattern driving the global circulation variations. Furthermore, we find that the global climate relevance of El Niño-like convection will be doubled by the end of this century, as projected consistently by 23 climate models. Such “rich nodes get richer” phenomenon in the network science is probably attributable to the dipolar rainfall changes over the western-central Pacific, coupled with the projected El Niño-like sea surface temperature changes. This study highlights the dominant role of El Niño-like convection on the global climate variations, especially under the future changing climate.
Association between mental health and professional quality of life among sexual assault victim advocates: a cross-sectional study
Authors: Hiroyama Natsuko , Ogata Yasuko , Sasaki Miki , Misumi Junko , Matsuzaki Masayo , Ikeda Masaomi , Okubo Noriko 
Published: December 2024

Abstract

Background
Sexual assault victim advocates are exposed to the traumatic events of victims, which can lead to occupational stress. Occupational stress specific to advocates who support victims can cause compassion fatigue and burnout, which can worsen their mental health. Furthermore, such exposure could also lead to compassion satisfaction, which, in turn, may buffer compassion fatigue and burnout. To improve the mental health among advocates for victims of sexual assault in Japan, this study was designed to evaluate a hypothesized model explaining the impact of occupational stress on their mental health.
Methods
This cross-sectional study was conducted with a self-administered questionnaire via mail. The sample comprised 560 advocates from one-stop support centers for victims of sexual assault. Questionnaires comprising the components of the hypothesized model, namely, compassion fatigue, burnout, compassion satisfaction, traumatic stress symptoms, and psychological distress were mailed. After using descriptive statistics, path analysis was conducted to test the hypotheses and the fitness of the model.
Results
Data from 250 participants were analyzed. The prevalence rates of compassion fatigue, burnout, and compassion satisfaction were 30%, 65%, and 4%, respectively. The hypothesized model had a good fit. Compassion fatigue had a significant positive effect on traumatic stress symptoms, psychological distress, and burnout. In addition, burnout had a significant positive effect on psychological distress. However, its association with traumatic stress symptoms was not significant. Compassion satisfaction had a significant negative effect on compassion fatigue and burnout.
Conclusions
Findings suggested that increased compassion satisfaction in advocates could buffer compassion fatigue and burnout, indirectly preventing the worsening of mental health of sexual assault victim advocates.
Analysis of Malignant Tumor Trends and Demographics in hospitalized patients in Kashi Prefecture from 2016 to 2023
Authors: Kade Nueraili , Yakufu Wusiman , Zhang Cheng , Wang Lin , Qian Qingqing , Liu Xiaochuan , Jia Long , Wu Chunfeng , Chen Weihua , Chen Tianxiang 
Published: December 2024

Abstract

Objective
To analyze the ranking, composition, trend changes, and distribution by gender and ethnicity of malignant tumors in hospitalized patients in the Kashi Prefecture from 2016 to 2023. This analysis aims to provide a reference for the prevention and treatment of malignant tumors, screening programs, public education, medical resource allocation, and the development of hospital developments in the Kashi prefecture.
Methods
We collected the front-page data of medical records for malignant tumor patients from 2016 to 2023 at four comprehensive hospitals in the Kashi prefecture, and analyze the ranking, composition, and trend changes of diseases among hospitalized patients with malignant tumors.
Results
A total of 8,386 patients with malignant tumors were hospitalized. The number of hospitalizations for patients with malignant tumors showed an increasing trend from 2016 to 2023. The incidence of malignant tumors began to rise rapidly after the age of 40 and peaks at 70 years old. Among the top 10 types of malignant tumors, there were 5,918 hospitalizations, accounting for 70.5% of cases. Of these, gastrointestinal malignancies constituted 43.6%. The most common malignant tumor in males was gastric cancer, while in females, it was cervical cancer. Differences in the ranking of diseases were observed among different ethnic groups, with gastrointestinal malignancies accounting for as high as 44.8% among minority ethnicities.
Conclusion
The high-incidence tumors in this area include malignant tumors of stomach, esophagus, cervix, breast, and colorecum. Health promotion and early screening should be conducted according to the distribution of malignant tumors, medical resources should be reasonably adjusted, and relevant discipline support should be strengthened.
Anatomical Insights and Clinical Implications of the Persistent Trigeminal Artery: A Cadaveric Study Utilizing Latex Injection Techniques
Authors: Soto Gervith Reyes , Cruz Julio Cesar Pérez , Rangel Carlos Castillo , Reyes Luis Delgado , Diaz Bernardo Cacho , Moreno Daniel Alejandro Vega , Chérubin Tshiunza Mpoyi , Nikolenko Vladimir , Pérez Eduardo Javier Valladares , Aguayo Francisco Castañeda , Rosario Andreina Rosario , Ramirez Manuel De Jesus Encarnación 
Published: December 2024

Abstract

Introduction: The persistent trigeminal artery (PTA) is a rare embryonic anastomosis connecting the internal carotid and basilar arteries. It persists in some individuals, with potential clinical implications, including cerebrovascular events and cranial nerve compression syndromes. Understanding the anatomical details of the PTA is crucial for neurosurgical planning and intervention, as its presence can alter hemodynamics and affect surgical outcomes.
Materials and Methods: This cadaveric study utilized a latex injection technique on a single male cadaver specimen. The brain was carefully extracted, and a seven-step brain injection technique was performed to visualize the PTA. Microsurgical dissection followed, documenting the PTA's origin, course, branching patterns, and anatomical relationships. Measurements were recorded using digital calipers, and high-resolution images were taken for analysis. Results: The PTA was identified originating from the posterior bend of the cavernous segment of the internal carotid artery. It coursed posterolaterally into the posterior cranial fossa, bifurcating into medial and lateral branches. Variations included slight tortuosity near its origin. The medial branch contributed to the posterior circulation, while the lateral branch supplied the superior cerebellar artery. These findings offer detailed insights into the PTA's anatomy, enhancing the understanding of its clinical significance.
Conclusion: This study enhances the anatomical understanding of PTA, highlighting its clinical significance in neurosurgical planning and intervention. Further research with larger samples is needed to generalize these findings.
Effects of monochromatic LED light qualities on the photosynthetic capacity and pigment content of Dunaliella salina
Authors: Zhao Tianze , Li Yongfu , Che Xingkai , Wu Haixing , Ye Yuchen , Fan Dingning , Li Zhendong , Zhao Yingjie , Ye Wei 
Published: December 2024

Abstract

Light quality is a crucial abiotic environmental factor that influences the growth and β-carotene accumulation on Dunaliella salina. However, the influence of the factor on the primary photochemical reactions of D. salina and the physiological mechanisms regulating β-carotene metabolism remains unclear at present. This study involved the batch culture of D. salina using low light (40 ± 5 μmol photons m-2 s-1, without inhibiting photosynthetic electron transfer) provided by different colored LEDs. Our results indicated that the growth rate, chlorophyll a/chlorophyll b/β-carotene content of D. salina cells were higher under BL and RL than under WL and GL. The light absorption rates of chloroplasts in algae cells under BL and RL (22.8% and 18.6%, respectively) were higher than those under WL and GL (14.0% and 10.2%, respectively), which was attributed to the reduced light energy dissipation and increased photochemical efficiency under BL and RL. BL and RL enhanced the photosynthetic efficiency and β-carotene synthesis capability of D. salina cells. It was observed that under low light, light quality has little influence on the synthesis process of β-carotene. However, two key genes involved in the degradation pathway of β-carotene (LUT5 and ABA2) are significantly downregulated under both BL and RL. The higher content of all-trans β-carotene under BL than under RL. This is attributed to the inhibition of the conversion pathway from all-trans β-carotene to ABA biosynthesis precursor (9-cis-β-carotene) is more pronounced under BL than under RL. This explains why D.salina has a higher content of all-trans β-carotene under BL, while synthesized more 9-cis-β-carotene under RL.
Limited consensus of marine viral diversity observed across techniques
Authors: Martinez-Garcia Manuel , Martinez-Hernandez Francisco , Gomez Monica Lluesma , Vila-Nistal Marina , Roux Simon , Fornas Oscar 
Published: December 2024

Abstract

Viruses are fundamental to many aspects of life influencing
ecosystem functions. The `lenses´ we use for exploring the viral
diversity have expanded, yet at the same time each has limitations
that constrain our view of the uncultured virosphere. Here, using
the same surface seawater sample, we compare short- and long-read
viromics (i.e., Illumina, PacBio–HiFi and MinION sequencing) along
with high-throughput single-virus genomics (SVG) to explore the
consensus between approaches to uncover the extant viral diversity.
Overall, ≈42,000 viral contigs (> 10 kb) were obtained,
resulting in ≈12,500 and ≈23,400 viral clusters at the genus and
species level, respectively, and predominantly infecting
Flavobacteriaceae and Pelagibacteracea. At the viral family level,
SVG recovered viruses with a more distinct taxonomic profile
compared to other methods
. At lower taxonomic resolution, only < 1% of all species and genera, including some of the most abundant one, were captured by all methods; reaching a value of ≈2% when only viromics -with or without hybrid assemblies- were considered. When exploring how the different methods resolve the co-occurring genomic microdiversity within species using as reference one of the most abundant and microdiverse virus, the uncultured pelagiphages vSAG 37-F6 discovered by SVG, none of the methods separately were able to assemble the complete genome; which was only achieved by combining all datasets. Similarly, neither of the viral clusters at the strain level was recovered by all methods. Our data suggest that the inherent bias of each method still represents a challenge for the recovery of viral diversity.
Uso de Trichoderma spp. e bioativador na promoção de crescimento vegetativo na cultura da soja
Authors: Thainá Fogliatto Moreira  , Fernando Wurzius  , Juliane Nicolodi Camera  , Jana Koefender  , André  Schoffel  
Published: December 2024

Na busca pelo aumento da produtividade da soja (Glycine max), muitas medidas alternativas de manejo têm sido adotadas, como a utilização de produtos biológicos associados com bioestimulantes, que visam incrementar o desenvolvimento da planta e ajudá-la a expressar seu máximo potencial durante seu ciclo. Diante disso, o objetivo do trabalho foi avaliar a influência do uso do bioativador de solo Penergetic K® e do fungo Trichoderma spp. no tratamento de sementes e sobre o crescimento vegetativo da parte aérea e radicular na soja. Para a realização desse experimento usou-se formulações comerciais à base de T. asperellum e T. harzianhum e o bioativador de solo Penergetic K® no tratamento das sementes da soja, as quais posteriormente foram submetidas a testes fisiológicos e a avaliação em casa de vegetação. Os resultados foram comparados pelo teste de Scott-Knott com nível de significância de 5%. O bioestimulante Penergetic K® associado com o fungo Trichoderma spp. pode ser utilizado no tratamento de semente pois eles influenciaram de forma positiva no crescimento vegetativo da parte aérea e radicular de plantas de soja.