bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect handlers via generalised continuations
Authors: HILLERSTRÖM DANIEL , LINDLEY SAM , ATKEY ROBERT 
Published: March 2020

AbstractPlotkin and Pretnar’s effect handlers offer a versatile abstraction for modular programming with user-defined effects. This paper focuses on foundations for implementing effect handlers, for the three different kinds of effect handlers that have been proposed in the literature: deep, shallow, and parameterised. Traditional deep handlers are defined by folds over computation trees and are the original construct proposed by Plotkin and Pretnar. Shallow handlers are defined by case splits (rather than folds) over computation trees. Parameterised handlers are deep handlers extended with a state value that is threaded through the folds over computation trees. We formulate the extensions both directly and via encodings in terms of deep handlers and illustrate how the direct implementations avoid the generation of unnecessary closures. We give two distinct foundational implementations of all the kinds of handlers we consider: a continuation-passing style (CPS) transformation and a CEK-style abstract machine. In both cases, the key ingredient is a generalisation of the notion of continuation to accommodate stacks of effect handlers. We obtain our CPS translation through a series of refinements as follows. We begin with a first-order CPS translation into untyped lambda calculus which manages a stack of continuations and handlers as a curried sequence of arguments. We then refine the initial CPS translation by uncurrying it to yield a properly tail-recursive translation and then moving towards more and more intensional representations of continuations in order to support different kinds of effect handlers. Finally, we make the translation higher order in order to contract administrative redexes at translation time. Our abstract machine design then uses the same generalised continuation representation as the CPS translation. We have implemented both the abstract machine and the CPS transformation (plus extensions) as backends for the Links web programming language.
What Will the Weather Do? Forecasting Flood Losses Based on Oscillation Indices
Authors: Guimarães Nobre Gabriela , de Moel Hans , Giuliani Matteo , Bischiniotis Konstantinos , Aerts Jeroen C. J. H. , Ward Philip J. 
Published: March 2020

AbstractAtmospheric oscillations are known to drive the large‐scale variability of hydrometeorological extremes in Europe, which can trigger flood events and losses. However, to date there are no studies that have assessed the combined influence of different large‐scale atmospheric oscillations on the probabilities of flood losses occurring. Therefore, in this study we examine the relationship between five indices of atmospheric oscillation and four classes of flood losses probabilities at subregional European scales. In doing so, we examine different combinations of atmospheric oscillations, both synchronous and seasonally lagged. By applying logistic regressions, we aim to identify regions and seasons where probabilities of flood losses occurring can be estimated by indices of atmospheric oscillation with higher skill than historical probabilities. We show that classes of flood losses can be predicted by synchronous indices of atmospheric oscillation and that in some seasons and regions lagged relationships may exist between the indices of atmospheric oscillation and the probability of flood losses. Furthermore, we find that some models generate increased (or decreased) probability of flood losses occurring when the indices are at their extreme positive or negative phases. A better understanding of the effects of atmospheric oscillations on the likelihood of flood losses occurring represents a step forward in achieving flood resilience in Europe. For instance, improved early predictions of the indices that represent such atmospheric oscillations, or the evidence of a lagged relationship between their teleconnections and floods, can significantly contribute to mitigating the socioeconomic burden of floods.
Using Multiple Signatures to Improve Accuracy of Substorm Identification
Authors: Haiducek John D. , Welling Daniel T. , Morley Steven K. , Ganushkina Natalia Yu , Chu Xiangning 
Published: March 2020

AbstractWe have developed a new procedure for combining lists of substorm onset times from multiple sources. We apply this procedure to observational data and to magnetohydrodynamic (MHD) model output from 1–31 January 2005. We show that this procedure is capable of rejecting false positive identifications and filling data gaps that appear in individual lists. The resulting combined onset lists produce a waiting time distribution that is comparable to previously published results, and superposed epoch analyses of the solar wind driving conditions and magnetospheric response during the resulting onset times are also comparable to previous results. Comparison of the substorm onset list from the MHD model to that obtained from observational data reveals that the MHD model reproduces many of the characteristic features of the observed substorms, in terms of solar wind driving, magnetospheric response, and waiting time distribution. Heidke skill scores show that the MHD model has statistically significant skill in predicting substorm onset times.
Patterns and Drivers of Carbon Dioxide Concentrations in Aquatic Ecosystems of the Arctic Coastal Tundra
Authors: Lougheed V. L. , Tweedie C. E. , Andresen C. G. , Armendariz A. M. , Escarzaga S. M. , Tarin G. 
Published: March 2020

AbstractMultiple aquatic ecosystems (pond, lake, river, lagoon, and ocean) on the Arctic Coastal Plain near Utqiaġvik, Alaska, USA, were visited to determine their relative atmospheric CO2 flux and how this may have changed over time. The nearshore coastal waters and large freshwater lakes were small sources of atmospheric CO2, whereas smaller waterbodies were substantial sources. pCO2 was linked to dissolved organic carbon concentrations across broad spatial and temporal scales, with greater concentrations found in smaller freshwater systems (i.e., ponds and rivers). On a day‐to‐day basis, water temperatures appeared to be the strongest driver of pCO2 levels in tundra ponds, where warmer temperatures likely stimulated microbial mineralization of carbon in both aquatic and hydrologically linked terrestrial environments. Large rainfall events, which may lead to inflow of carbon‐rich groundwater into these ponds, also were associated with increased daily average pCO2. Based on comparison to historical data, we estimate that CO2 concentrations in tundra ponds have increased more than 1.8 times over the past 40 years. Quantifying CO2 flux from these abundant aquatic ecosystems on the Arctic Coastal Plain and elsewhere in the high northern latitudes will likely have important implications for furthering understanding of landscape‐level and nearshore carbon dynamics in the Arctic.
Tumour-agnostic drugs in paediatric cancers
Authors: Chisholm Julia C. , Carceller Fernando , Marshall Lynley V. 
Published: March 2020

SummaryThe recognition that new cancer drugs can be truly tumour-agnostic based on mechanism-of-action is important for paediatric cancers, where access to novel targeted therapies developed for adult indications has sometimes been problematic. The recently approved drug larotrectinib is an excellent case study of the development of a tumour-agnostic drug relevant to children.
Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure
Authors: Wu Dechao , Jian Chongshu , Peng Qi , Hou Tingting , Wu Keling , Shang Bizhi , Zhao Minglei , Wang Yanru , Zheng Wen , Ma Qi , Li Chuan-Yun , Cheng Heping , Wang Xianhua , Zhao Ling 
Published: March 2020

AbstractFatty acids are the most major substrate source for adult cardiac energy generation. Prohibitin 2 (PHB2), a highly conserved protein located in mitochondrial inner membrane, plays key roles in cellular energy metabolic homeostasis. However, its functions in regulating cardiac fatty acid metabolism have remained largely unknown. Our study demonstrates that cardiac-specific knockout of Phb2 leads to accumulation of lipid droplets and causes heart failure. Mechanistically, ablation of PHB2 impairs cardiac fatty acid oxidation (FAO) through downregulating carnitine palmitoyltransferase1b (CPT1b), a rate-limiting enzyme of cardiac mitochondrial FAO. Moreover, overexpression of CPT1b alleviates impaired FAO in PHB2-deficient cardiomyocytes. Thus, our study provides direct evidence for the link between PHB2 and cardiac fatty acid metabolism. Our study points out that PHB2 is a potential FAO regulator in cardiac mitochondrial inner membrane, as well as the connection between PHB2 and CPT1b and their relationships to cardiac pathology especially to cardiac fatty acid metabolic disorder.
Can a simple topological-constraints-based model predict the initial dissolution rate of borosilicate and aluminosilicate glasses?
Authors: Gin Stéphane , Wang Mengyi , Bisbrouck Nicolas , Taron Mélanie , Lu Xiaonan , Deng Lu , Angeli Frédéric , Charpentier Thibault , Delaye Jean-Marc , Du Jincheng , Bauchy Mathieu 
Published: March 2020

AbstractTuning glass composition to obtain targeted properties generally relies on empirical approaches. However, a deep understanding of the physical and chemical mechanisms linking glass composition to its structure and properties would enable developing reliable predictive models. Indeed, although empirical models are usually able to interpolate composition–property relationships within a given compositional envelope, they often fail at extrapolating predictions far from their training domain. Here, as an alternative route to empirical models, we show that a structural descriptor based on the number of topological constraints per atom can be used to predict the initial dissolution rate of aluminosilicate and borosilicate glasses after being parameterized on different families of glasses (specific series of borosilicate glasses). Sixteen glasses belonging to these families were studied and their initial dissolution rates were determined at 90 °C and pH90 °C = 9, covering rates spanning over 5 orders of magnitude. The model based on topological constraints was trained based on seven select borosilicate glasses (R2 = 0.997) and used to predict the dissolution rate of nine additional borosilicate and aluminosilicate glasses. We show that, provided that corrections are made for high alkali content glasses that dissolve incongruently (preferential release of Na), the model gives reasonable predictions, even far from its training domain.
Formation of pre-pore complexes of pneumolysin is accompanied by a decrease in short-range order of lipid molecules throughout vesicle bilayers
Authors: Faraj Bayan H. A. , Collard Liam , Cliffe Rachel , Blount Leanne A. , Lonnen Rana , Wallis Russell , Andrew Peter W. , Hudson Andrew J. 
Published: March 2020

AbstractOligomers of pneumolysin form transmembrane channels in cholesterol-containing lipid bilayers. The mechanism of pore formation involves a multistage process in which the protein, at first, assembles into a ring-shaped complex on the outer-bilayer leaflet. In a subsequent step, the complex inserts into the membrane. Contrary to most investigations of pore formation that have focussed on protein changes, we have deduced how the lipid-packing order is altered in different stages of the pore-forming mechanism. An optical tweezing apparatus was used, in combination with microfluidics, to isolate large-unilamellar vesicles and control exposure of the bilayer to pneumolysin. By monitoring Raman-scattered light from a single-trapped liposome, the effect of the protein on short-range order and rotational diffusion of lipids could be inferred from changes in the envelope of the C–H stretch. A significant change in the lipid-packing order takes place during assembly of pre-pore oligomers. We were not able to detect a change in the lipid-packing order during the initial stage of protein binding, or any further change during the insertion of oligomers. Pre-pore complexes induce a transformation in which a bilayer, resembling a liquid-ordered phase is changed into a bilayer resembling a fluid-liquid-disordered phase surrounding ordered microdomains enriched in cholesterol and protein complexes.
Western gorilla space use suggests territoriality
Authors: Morrison Robin E. , Dunn Jacob C. , Illera Germán , Walsh Peter D. , Bermejo Magdalena 
Published: March 2020

AbstractThe evolutionary origins of how modern humans share and use space are often modelled on the territorial-based violence of chimpanzees, with limited comparison to other apes. Gorillas are widely assumed to be non-territorial due to their large home ranges, extensive range overlap, and limited inter-group aggression. Using large-scale camera trapping, we monitored western gorillas in Republic of Congo across 60 km2. Avoidance patterns between groups were consistent with an understanding of the “ownership” of specific regions, with greater avoidance of their neighbours the closer they were to their neighbours’ home range centres. Groups also avoided larger groups’ home ranges to a greater extent, consistent with stronger defensive responses from more dominant groups. Our results suggest that groups may show territoriality, defending core regions of their home ranges against neighbours, and mirror patterns common across human evolution, with core areas of resident dominance and larger zones of mutual tolerance. This implies western gorillas may be a key system for understanding how humans have evolved the capacity for extreme territorial-based violence and warfare, whilst also engaging in the strong affiliative inter-group relationships necessary for large-scale cooperation.
Autologous cord blood cell therapy for neonatal hypoxic-ischaemic encephalopathy: a pilot study for feasibility and safety
Authors: Tsuji Masahiro , Sawada Mariko , Watabe Shinichi , Sano Hiroyuki , Kanai Masayo , Tanaka Emi , Ohnishi Satoshi , Sato Yoshiaki , Sobajima Hisanori , Hamazaki Takashi , Mori Rintaro , Oka Akira , Ichiba Hiroyuki , Hayakawa Masahiro , Kusuda Satoshi , Tamura Masanori , Nabetani Makoto , Shintaku Haruo 
Published: March 2020

AbstractNeonatal hypoxic-ischaemic encephalopathy (HIE) is a serious condition; many survivors develop neurological impairments, including cerebral palsy and intellectual disability. Preclinical studies show that the systemic administration of umbilical cord blood cells (UCBCs) is beneficial for neonatal HIE. We conducted a single-arm clinical study to examine the feasibility and safety of intravenous infusion of autologous UCBCs for newborns with HIE. When a neonate was born with severe asphyxia, the UCB was collected, volume-reduced, and divided into three doses. The processed UCB was infused at 12–24, 36–48, and 60–72 hours after the birth. The designed enrolment was six newborns. All six newborns received UCBC therapy strictly adhering to the study protocol together with therapeutic hypothermia. The physiological parameters and peripheral blood parameters did not change much between pre- and postinfusion. There were no serious adverse events that might be related to cell therapy. At 30 days of age, the six infants survived without circulatory or respiratory support. At 18 months of age, neurofunctional development was normal without any impairment in four infants and delayed with cerebral palsy in two infants. This pilot study shows that autologous UCBC therapy is feasible and safe.
Stereotactic Cortical Atlas of the Domestic Canine Brain
Authors: Johnson Philippa J. , Luh Wen-Ming , Rivard Benjamin C. , Graham Kathleen L. , White Andrew , FitzMaurice Marnie , Loftus John P. , Barry Erica F. 
Published: March 2020

AbstractThe domestic canine (canis familiaris) is a growing novel model for human neuroscientific research. Unlike rodents and primates, they demonstrate unique convergent sociocognitive skills with humans, are highly trainable and able to undergo non-invasive experimental procedures without restraint, including fMRI. In addition, the gyrencephalic structure of the canine brain is more similar to that of human than rodent models. The increasing use of dogs for non-invasive neuroscience studies has generating a need for a standard canine cortical atlas that provides common spatial referencing and cortical segmentation for advanced neuroimaging data processing and analysis. In this manuscript we create and make available a detailed MRI-based cortical atlas for the canine brain. This atlas includes a population template generated from 30 neurologically and clinically normal non-brachycephalic dogs, tissue segmentation maps and a cortical atlas generated from Jerzy Kreiner’s myeloarchitectonic-based histology atlas. The provided cortical parcellation includes 234 priors from frontal, sensorimotor, parietal, temporal, occipital, cingular and subcortical regions. The atlas was validated using an additional canine cohort with variable cranial conformations. This comprehensive cortical atlas provides a reference standard for canine brain research and will improve and standardize processing and data analysis and interpretation in functional and structural MRI research.
System for the remote control and imaging of MW fields for spin manipulation in NV centers in diamond
Authors: Mariani Giacomo , Nomoto Shuhei , Kashiwaya Satoshi , Nomura Shintaro 
Published: March 2020

AbstractNitrogen-vacancy (NV) centers in diamond have been used as platforms for quantum information, magnetometry and imaging of microwave (MW) fields. The spatial distribution of the MW fields used to drive the electron spin of NV centers plays a key role for these applications. Here, we report a system for the control and characterization of MW magnetic fields used for the NV spin manipulation. The control of the MW field in the vicinity of a diamond surface is mediated by an exchangeable lumped resonator, coupled inductively to a MW planar ring antenna. The characterization of the MW fields in the near-field is performed by an FFT imaging of Rabi oscillations, by using an ensemble of NV centers. We have found that the Rabi frequency over a lumped resonator is enhanced 22 times compared to the Rabi frequency without the presence of the lumped resonator. Our system may find applications in quantum information and magnetometry where a precise and controlled spin manipulation is required, showing NV centers as good candidates for imaging MW fields and characterization of MW devices.
Designing bioinspired brick-and-mortar composites using machine learning and statistical learning
Authors: Morsali Seyedreza , Qian Dong , Minary-Jolandan Majid 
Published: March 2020

AbstractThe brick-and-mortar structure inspired by nature, such as in nacre, is considered one of the most optimal designs for structural composites. Given the large number of design possibilities, extensive computational work is required to guide their manufacturing. Here, we propose a computational framework that combines statistical analysis and machine learning with finite element analysis to establish structure–property design strategies for brick-and-mortar composites. Approximately 20,000 models with different geometrical designs were categorized into good and bad based on their failure modes, with statistical analysis of the results used to find the importance of each feature. Aspect ratio of the bricks and horizontal mortar thickness were identified as the main influencing features. A decision tree machine learning model was then established to draw the boundaries of good design space. This approach might be used for the design of brick-and-mortar composites with improved mechanical properties.
Involvement of p53-dependent apoptosis signal in antitumor effect of Colchicine on human papilloma virus (HPV)-positive human cervical cancer cells
Authors: Yan Luchun , Huang Hao , Zhang Ying , Yuan Xinrong , Yan Zhaohua , Cao Chunyan , Luo Xiping 
Published: March 2020

Abstract
Colchicine, a plant-derived alkaloid with relatively low toxicity on normal human epidermal keratinocytes (HEKn), has selective inhibitory effect on the growth of CaSki (HPV16-positive) and HeLa (HPV18-positive) human cervical cancer cell lines via the induction of apoptosis. Colchicine (2.5, 5.0 and 10.0 ng/ml) significantly reduced the expression of human papilloma virus (HPV) 16 E6/E7 mRNA and protein in CaSki and HeLa cells. Moreover, reduced expression of E6 and E7 induced by Colchicine resulted in the up-regulation of tumor suppressor proteins, p53 and Rb, as well as down-regulation of phospho Rb (pRb) protein. In addition, Bax, cytosolic cytochrome c and cleaved caspase-3 protein were increased while Bcl-2 protein was decreased significantly by 48 h of Colchicine treatment. These results implied that Colchicine could be explored as a potent candidate agent for the treatment and prevention of HPV-associated cervical cancer without deleterious effects.
Statin use and the prognosis of patients with hepatocellular carcinoma: a meta-analysis
Authors: Li Xiaofei , Liu Liwen , Hu Yongtao 
Published: March 2020

Abstract
Background: Association between statin use and prognosis in patients with hepatocellular carcinoma (HCC) remains unknown. We performed a meta-analysis of follow-up studies to systematically evaluate the influence of statin use on clinical outcome in HCC patients.
Methods: Studies were obtained via systematic search of PubMed, Cochrane’s Library, and Embase databases. A randomized-effect model was used to pool the results. Subgroup analyses were performed to evaluate the influence of study characteristics on the association.
Results: Nine retrospective cohort studies were included. Overall, statin use was associated with a reduced all-cause mortality in HCC patients (risk ratio [RR]: 0.81, 95% CI: 0.74–0.88, P &lt; 0.001; I2 = 63%). Subgroup analyses showed similar results for patients with stage I-III HCC (RR: 0.83, 0.79, and 0.90 respectively, P all &lt; 0.01) and patients after palliative therapy for HCC (RR: 0.80, P &lt; 0.001), but not for patents with stage IV HCC (RR: 0.91, P = 0.28) or those after curative therapy (RR: 0.92, P = 0.20). However, the different between subgroups were not significant (both P &gt; 0.05). Moreover, statin use was associated with reduced HCC-related mortality (RR: 0.78, P = 0.001) in overall patient population and HCC recurrence in patients after curative therapies (RR: 0.55, P &lt; 0.001).
Conclusions: Satin use is associated with reduced mortality and recurrence of HCC. These results should be validated in prospective cohort studies and randomized controlled trials.