bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative Diabetes Insipidus in Patients Undergoing Off-Pump Coronary Bypass Grafting Surgery: A Study on Incidence, Related Factors and Clinical Significance
Authors: Zhong Peng , Guo Zijian , Lu Jiakai , Cheng Weiping , Mu Jin , Yang Yanwei 
Published: December 2020

Abstract
BackgroundPerioperative diabetes insipidus (DI) is a serious complication occurring in patients undergoing off-pump coronary artery bypass grafting (OPCABG). MethodsThis was a retrospective study of 199 patients who underwent OPCABG surgery in Anzhen hospital, Beijing, China, between January 2019 to December 2019. Patients were divided into a DI(+) group and a DI(-) group according to perioperative urine condition. The incidence of perioperative DI in patients undergoing OPCABG surgery was calculated as the main outcome. Multivariable binary logistic regression analysis was used to identify independent prognostic factors of DI.ResultsPerioperative DI occurred in 43.2% (86/199) of these patients. Mean patient age was 62.5 ± 9.0 years, and 156 (78.4%) were male. Multivariable logistic regression analysis showed a correlation between BMI(OR=0.772, 95%CI[0.670-0.890], P＜0.001), Crystal quantity(OR=1.001, 95%CI[1.000-1.001], P=0.008), perioperative Cr(OR=0.965, 95%CI[0.937-0.993], P=0.016). The DI(+) group had a significantly higher imbalance postoperative PH condition(41.9% vs 28.3%, P<0.05), higher median mechanical ventilation time than the DI(-) group (22.0 vs. 20.5, P<0.01) and higher median of ICU stay hours(27.0 vs 31.0, P=0.041).Conclusion﻿Coronary artery disease(CAD) patients underwent OPCABG surgery were easy to have perioperative DI, which had a higher ICU stay and mechanical ventilation time than those without DI. BMI, Crystal quantity, perioperative creatinine was associated with the presence of DI. Prospective studies are needed to validate these findings.
The Association Between Dynamic Changes in Serum Presepsin Levels and Mortality in Immunocompromised Patients with Sepsis: A Prospective Cohort Study
Authors: Lee Jongmin , Kim Seo Hyun , Kim Kyung Hoon , Jeong Na Ri , Kim Seok Chan , Oh Eun-Jee 
Published: December 2020

Abstract

Background: Presepsin is a subtype of soluble CD14 that is increased in the blood of septic patients. We investigated the role of dynamic changes in serum presepsin levels in critically ill, immunocompromised patients with sepsis.Methods: This is a prospective cohort study that included 119 adult patients who were admitted to the intensive care unit (ICU) between March 2019 and June 2020. Sepsis and septic shock were defined as Sepsis-3. Patients were classified into one of the following diagnostic groups: no sepsis, sepsis, and septic shock. Presepsin level was measured on day 1 and day 3 after ICU admission. The primary outcome was in-hospital mortality.Results: Of the 119 patients, sepsis was diagnosed in 40 patients (33.6%) and septic shock was diagnosed in 60 (50.4%) patients. The Simplified Acute Physiology Score (SAPS) 3 and Sequential Organ Failure Assessment score on day 1 were 75.5 ± 14.9 and 9.0 (6.5–11.5), respectively, and the overall hospital mortality was 44.5%. In 61 immunocompromised patients, presepsin levels on day 1 were higher in patients with sepsis than those in patients without sepsis (1203.0 [773.0–2484.0] vs. 753.0 [603.5–1092.0] ng/ml; P = 0.004). The area under the curve (AUC) of presepsin for diagnosing sepsis in immunocompromised patients was 0.87, which was comparable with that of procalcitonin (AUC, 0.892). Presepsin levels on day 3 were higher in patients who died in the hospital than in those who survived (1965.0 [1149.0–3423.0] vs. 933.0 [638.0–1571.0]; P = 0.001). In immunocompromised patients who died in the hospital, presepsin levels on day 3 were significantly higher than those on day 1 (P = 0.018). In the multivariate analysis, ΔPresepsin+ (ΔPresepsin concentrations [day3 – day1] > 0) alone was independently correlated with in-hospital mortality in immunocompromised patients (odds ratio, 6.22; 95% confidence interval, 1.33–29.06; P = 0.020).Conclusion: These findings suggest that dynamic changes in presepsin levels between day 1 and day 3 are associated with in-hospital mortality in patients with sepsis, especially in immunocompromised patients.
Inhaled Nitric Oxide Preserves Ventricular Function During Resuscitation Using a Percutaneous Mechanical Circulatory Support Device in a Porcine Cardiac Arrest Model – An Echocardiographic Myocardial Work Analysis
Authors: Nix Christoph , Zayat Rashad , Ebeling Andreas , Goetzenich Andreas , Chandrasekaran Uma , Rossaint Rolf , Hatam Nima , Derwall Matthias 
Published: December 2020

Abstract
BackgroundResuscitation using a percutaneous mechanical circulatory support device (iCPR) improves survival after cardiac arrest (CA). We hypothesized that the addition of inhaled nitric oxide (iNO) during iCPR might prove synergistic, leading to improved myocardial performance due to lowering of right ventricular (RV) afterload, left ventricular (LV) preload, and myocardial energetics. This study aimed to characterize the changes in LV and RV function and global myocardial work indices (GWI) following iCPR, both with and without iNO, using 2-D transesophageal echocardiography (TEE) and GWI evaluation as a novel non-invasive measurement. MethodsIn 10 pigs, iCPR was initiated following electrically-induced CA and 10min of untreated ventricular fibrillation (VF). Pigs were randomized to either 20ppm (20ppm, n=5) or 0ppm (0ppm, n=5) of iNO in addition to therapeutic hypothermia for 5h following ROSC. All animals received TEE at five pre-specified time-points and invasive hemodynamic monitoring. ResultsLV end-diastolic volume (LVEDV) increased significantly in both groups following CA. iCPR alone led to significant LV unloading at 5h post-ROSC with LVEDV values reaching baseline values in both groups (20ppm: 68.2±2.7 vs. 70.8±6.1 mL, p=0.486; 0ppm: 70.8±1.3 vs. 72.3±4.2 mL, p=0.813, respectively). LV global longitudinal strain (GLS) increased in both groups following CA. LV-GLS recovered significantly better in the 20ppm group at 5h post-ROSC (20ppm: -18±3% vs. 0ppm: -13±2%, p=0.025). LV-GWI decreased in both groups after CA with no difference between the groups. Within 0ppm group, LV-GWI decreased significantly at 5h post-ROSC compared to baseline (1,125±214 vs. 1,835±305 mmHg%, p=0.011). RV-GWI was higher in the 20ppm group at 3h and 5h post-ROSC (20ppm: 189±43 vs. 0ppm: 108±22 mmHg%, p=0.049 and 20ppm: 261±54 vs. 0ppm: 152±42 mmHg%, p=0.041). The blood flow calculated by the Impella controller following iCPR initiation correlated well with the pulsed-wave Doppler (PWD) derived pulmonary flow (PWD vs. controller: 1.8±0.2 vs. 1.9±0.2L/min, r=0.85, p=0.012). ConclusionsiCPR after CA provided sufficient unloading and preservation of the LV systolic function by improving LV-GWI recovery. The addition of iNO to iCPR enabled better preservation of the RV-function as determined by better RV-GWI. Additionally, Impella-derived flow provided an accurate measure of total flow during iCPR.
Vaccine Preventable Diseases in Children Following a Nationwide Sanitation Campaign
Authors: Singh Parvati , Forthal Donald N. , Shah Manisha , Bruckner Tim A. 
Published: December 2020

Abstract
Background: India consistently reports the most diphtheria, pertussis, tetanus and measles cases worldwide. Persistent exposure to fecal pathogens due to open defecation may cause environmental enteropathy that in may lead to undernutrition and vaccine failure in under 5-year old (u5) children. The Swachh Bharat Mission (SBM) program in India, launched in 2014, aimed to construct toilets for every household nationwide and reduce open defecation. Objective: We examine whether increased household toilet availability in Indian districts corresponds with a reduction in 4 Vaccine Preventable Diseases (VPDs): diphtheria, pertussis, tetanus and measles.Methods: We retrieved data on district level change in the prevalence (per 1000 u5 children) of 4 VPDs, from 2013 (pre-SBM) to 2016 (post-SBM). We obtained data on our exposure, the change in the percentage of households with toilets (per district), from three large national surveys conducted in 2013 and 2016. We used linear regression analysis which controlled for change over time in socioeconomic factors, health system-related covariates and pre-SBM prevalence of VPDs.Results: A one percentage point increase in households with toilets corresponds with 0.33 fewer measles cases per 1000 u5 children in that district (coefficient: -0.33, 95% CI: -0.0641, -0.014; p < 0.05). We observe no relation with diphtheria, pertussis, or tetanus. Conclusion: Rapid improvements in ambient sanitation through increased toilet availability (and reduction in open defecation) may correspond with reduction in the prevalence of measles in u5 children.
Differences in Axial Length and IOLs Power Basing on Alternative A-Scan or Fellow-Eye Biometry in Macular-off Rhegmatogenous Retinal Detachment Eyes
Authors: Liu Rui , Li Hongrong , Li Qingchen 
Published: December 2020

Abstract
Background: To observe the potential refractive prediction error basing on alternative A-scan ultrasound and fellow-eye biometry for phacovitrectomy in macula-off rhegmatogenous retinal detachment (RRD) eyes, when the optic biometry IOLMaster fails to obtain data.Methods: Phakic macula-off RRD eyes without axial length (AL) measured using IOLMaster were included. Vitrectomy with silicone oil tamponade but not lens extraction was performed. Preoperative AL was measured using A-scan ultrasound, and postoperative AL, as well as fellow-eye biometry, was obtained using IOLMaster. The IOLs power was calculated according to preoperative A-scan, postoperative IOLMaster and fellow-eye AL.Results: AL measured by alternative A-scan (AL-US) was 25.39±2.14 mm, and AL of fellow-eyes (AL-FE) was 25.85±2.16 mm, and AL in eyes with silicone oil tamponade (AL-SO) was 26.08±2.53 mm. The Bland-Altman agreements among AL-US, AL-FE and AL-SO were well (95.5%, 21/22 of cases were in LoA). The mean IOLs power calculated using AL-US (Power-US) was 16.81±7.19 D, using AL-FE (Power-FE) was 14.74±6.95 D, and using AL-SO (Power-SO) was 13.54±8.32 D. The difference between AL-US and AL-SO was significant (P<0.05), while that between AL-FE and AL-SO was not (P>0.05). The difference between Power-US and Power-SO was significant (P<0.05), while that between Power-FE and Power-SO was not (P>0.05).Conclusion: The alternative A-scan ultrasound leads to a significant difference in AL and prediction error in IOLs power, while fellow-eye biometry provided similar results compared with those of silicone oil-filled eyes after RRD repair.
Patients with Somatic Illness and Accompanying Psychomental Health Problems have Similar Psychological Capacity Impairments Like Patients with Mental Disorders
Authors: Muschalla Beate , Jöbges Michael 
Published: December 2020

Abstract
Background: In patients with somatic illness and additional psychomental health problem, not only motor or sensory functions may be impaired, but also psychological skills which become more and more important for work ability in our modern working world. There are presently no data about the type and distribution of capacity impairments in patients with comorbid somatic and psychomental health problems. These data are however important for estimation of diagnostic and therapy requirements. This research thus investigates capacity impairment in patients who suffer from mixed somatic and mental health problems. Research questions are: (1) How many of patients with comorbid somatic and mental disorders suffer from clinically relevant capacity impairments according to Mini-ICF-APP? and (2) Do patients with different somatic diseaeses have different capacity impairments? Methods: 402 patients with comorbid mental and somatic health problems (out of 1016 screened patients) were in depth investigated in a clinical interview for mental disorders (MINI) and capacity limitations (Mini-ICF-APP). Results: At least half of the patients had any clinically relevant capacity impairment. Neurology patients (67%) and orthopedic patients (72%) were more often affected than cardiology patients (50.5%). Orthopedic patients are slightly more impaired in self-care, neurology and orthopedic patients are more impaired in mobility, and cardiology patients are less impaired in assertiveness.Conclusion: In comparison to patients with chronic mental health problems the number of capacity impairments is similar. The data from this study are important in order to estimate diagnostic and therapeutic needs in respect to capacity training or compensation of capacity impairments.
A Soft Wearable and Full Textile Piezoresistive Sensor for Plantar Pressure Capturing
Authors: Tan Yongsong , Ivanov Kamen , Mei Zhanyong , Li Hui , Lubich Ludwig , Li Huihui , Wang Chaoxia , wang lei 
Published: December 2020

Abstract
The trends of health wearable monitoring system have led to growing demands for gait capturing device. The comfortability and durability under repeated stress in the existing sensor-enabled footwear are still problems. Herein, a flexible textile piezoresistive sensor (TPRS) consisting of rG-cotton fabric electrode and Ag fabric circuit electrode is prepared. Based on the mechanical and electrical properties of two fabric electrodes, the TPRS exhibits superior sensing performance, which includes high sensitivity of 3.96kPa-1 in the lower pressure range of 0-36kPa, wide force range (0-800 kPa), fast response time (170 ms), remarkable durability stability (1000 cycles) and dection ability in differrent pressures. For practical application of capturing plantar pressure, six TPRSs are mounted on a flexible printed circuit board and integrated into an insole. The dynamic plantar pressure distribution is displayed through drawing the pressure maps during walking. The proposed full textile piezoresistive sensor is a strong candidate for next-generation plantar pressure wearables monitoring device.
Effects of Single Transplantation and Multiple Transplantation of Human Umbilical Cord Mesenchymal Stem Cells on the Recovery of Ovarian Function in the Treatment of Premature Ovarian Failure in Mice
Authors: Lv Xiaodan , Guan Chunyi , Li Ying , Su Xing , Zhang lu , Wang Xueqin , Xu Ma , Xia Hong-Fei 
Published: December 2020

Abstract
Background: Previous studies have reported that transplantation of mesenchymal stem cells (MSCs) from many human tissues can improve ovarian dysfunction. However, the therapeutic effects of single injection of MSCs and multiple injections of MSCs on premature ovarian failure (POF) have not been reported yet. In this study, we used long-term follow-up to study the effect of human umbilical cord mesenchymal stem cell (hUC-MSCs) on the functional recovery of mouse POF models. Methods: In this study, we used a mouse model of premature ovarian failure induced by the combination of 120mg/kg cyclophosphamide and 30mg/kg busulfan. Enzyme-linked immunosorbent assay (ELISA) was used to detect estradiol (E2) and follicle stimulating hormone (FSH) levels in mouse serum. Evaluate ovarian function by counting follicles, ovarian weight, number of proliferating cells, anti-Mullerian hormone (AMH) and oocytes. Results: Our study shows that hUC-MSCs have obvious therapeutic effect for the POF mice model, and treatment effect of multiple transplantation is better than single transplantation. Mesenchymal stem cells were detected in follicular granulosa cells with tracer of the ovarian tissue freezing slice, which show hUC-MSCs to selectively migration and stay in damaged tissues. Genome Array screened a number of differentially expressed genes, the hUC-MSCs can change the level of expression of certain genes in the ovarian tissue, thus affecting ovarian function, and laid the foundation for us to further explore the mechanism of hUC-MSCs treatment of premature ovarian failure. Conclusion: This study demonstrated that hUC-MSCs transplantation significantly restored ovarian function after chemotherapy-induced damage.
Cancer Risk in Tuberculosis Patients in A High Endemic Area
Authors: Chen Guang-liang , Guo Li , Yang Shun’e , Ji Dong-Mei 
Published: December 2020

Abstract
ObjectiveTo evaluate the risk of cancer after tuberculosis (TB), we performed a case-control study of the prevalence rate of TB in a high endemic area.MethodsFrom January 2016 to December 2018, a total of 45,455 patients were consecutively enrolled and divided into a malignant tumor group (n=32,539) and a benign tumor group (n=12,916). Patients with active and inactive TB before the diagnosis of cancer were retrospectively identified in the two groups.ResultsA significantly higher prevalence rate of TB was found in the malignant tumor group (n=1776, 5.46%) than in the control (benign tumor) group (n=175, 1.35%) (p<0.0001). The highest and lowest prevalence rates of TB in the malignant group were in patients with non-Hodgkin's lymphoma (16.74%) and thyroid cancer (0.77%), respectively. In multivariate analysis adjusting for age, sex, and ethnicity, TB remained an independent risk factor for all cancers (odds ratio (OR) 1.68; 95% confidence interval (CI) 1.43-1.97). Furthermore, TB was associated with a significantly higher risk of non-Hodgkin's lymphoma, cervical cancer, esophageal cancer, “other” cancers, ovarian cancer, and breast cancer. Moreover, females with TB were more likely to develop cancer than males (p<0.0001), except for esophageal cancer and lymphoma.ConclusionTB patients have an elevated cancer risk. A screening strategy for TB should be taken into consideration before treatment in patients with some cancer types that are associated with a high prevalence rate of TB.
Artemin is Upregulated by TrkB agonist and Protects the Immature Retina against Hypoxic-ischemic Injury by Suppressing Neuroinflammation and Astrogliosis
Authors: Huang Hsiu-Mei , Huang Chao-Ching , Poon Linda Yi-Chieh , Chang Ying-Chao 
Published: December 2020

Abstract
Background: Hypoxic-ischemia (HI) is a major cause of acquired visual impairment in children of developed countries. Previous studies have shown that systemic administration of 7,8-dihydroxyﬂavone (DHF), a selective tropomyosin receptor kinase B (TrkB) agonist, provided long-term neuroprotection against HI injury in immature retina. However, the target genes and the mechanisms of the neuroprotective effects of TrkB signaling are not known. Methods: HI retinal injury was induced by unilateral common carotid artery ligation followed by 8% oxygen for 2 hrs at P7 rat pups. DHF was administered intraperitoneally at 2 hrs before and 18 hrs after HI injury. Polymerase chain reaction (PCR) array was used to identify genes upregulated after DHF treatment, then confirmed with quantitative real-time reverse transcriptase PCR and Western blot. Effects of the downstream mediator of DHF were assessed by intravitreal injection of neutralizing antibody at 4 hrs after DHF administration (24 hrs after HI). Meanwhile, the target protein was injected into the vitreous at 24 hrs after HI to validate its protective effect when exogenously supplemented. The outcomes were assessed by electroretinography and by histopathological sections of the rat retina. Results: Systemic DHF treatment after HI significantly increased the expression of artemin (ARTN) gene and protein at P8 and P10, respectively. The neuroprotective effects of DHF were inhibited after the blockade of ARTN protein with an increase in neuroinflammation and astrogliosis. ARTN treatment showed long-term protection against HI injury at both the histopathological and functional levels. The neuroprotective effects of ARTN were related to a decrease in microglial activation at P17, and attenuation of astrogliosis at P29. ARTN enhances phosphorylation of RET, ERK, and JNK, but not AKT or p38 in the immature retina. Conclusions: Neuroprotective effect of TrkB agonist is partially exerted through a mechanism that involves ARTN because the protective effect is ameliorated by ARTN sequestration. ARTN treatment after HI injury protects the immature retina by attenuating the late neuroinflammation and astrogliosis in the immature retina via ARTN/RET/JNK/ERK signaling pathway. ARTN can be a strategy to provide long-term protection in immature retina against HI injury.
Efficacy and Safety of PARP&nbsp;Inhibitors in Advanced or Metastatic Triple-negative Breast Cancer: A Systematic Review and Meta-analysis
Authors: Liu Xu , Wu Kan , Zheng Dan , Luo Chuanxu , Fan Yu , Zhong Xiaorong , Zheng Hong 
Published: December 2020

Abstract
BackgroundPoly (ADP-ribose) polymerase (PARP) inhibitors have shown promising results in metastatic triple-negative breast cancers (TNBC). We performed a systematic review and meta-analysis to evaluate the efficacy and safety of this drug in patients with advanced or metastatic TNBC.MethodsOn August 2020, we searched all published phase II/III clinical studies of PARP inhibitors in advanced/metastatic TNBC patients. Data were extracted independently by two authors and analyzed using Review Manager software version 5.3. End points included overall response rate (ORR), progression-free survival (PFS) and adverse events.ResultsTen clinical trials were identified, with a total of 1495 patients included. Pooled analyses showed that the addition of PARP inhibitors could provide a significant improvement of ORR (risk ratio [RR]=2.00, 95% confidence interval [CI]: 1.14–3.50, p=0.02) and PFS (hazard ratio [HR]=0.68, 95 %Cl: 0.59-0.77, p<0.0001) compared to chemotherapy in the whole population. In subgroup analysis, BRCA mutated patients have a higher objective response to PARP inhibitor, with a RR of 2.85 (95%CI: 1.34–6.06, p=0.007) compared to BRCA wild-type patients. However, no significant differences in ORR were observed between homologous recombination deficiency (HRD) positive and non-HRD subgroup (RR=1.82, 95%CI: 0.81–4.08, p=0.14). Hematologic toxicities were common adverse events of PARP inhibitors.ConclusionsPARP inhibitors are an effective option for the treatment of advanced or metastatic TNBC patients. BRCA mutated patients could derive more benefits from PARP inhibitors when compared to BRCA wild-type patients. In clinical application, hematological toxicity related to PARP inhibitors should be monitored regularly.
High-precision Online Prediction Model of Plate Crown Based on Multi-factor Interaction Mechanism
Authors: ZhiQiang Li , Liu YuanMing , Wang Tao , Vladimirovih Ignatov Aleksei , Huang QingXue 
Published: December 2020

Abstract
The crown is a key quality index of strip and plate. Up to now, many plate crown prediction models have been established, however, the calculation accuracy of these traditional models is not very high. This is because these models only consider the effect of various influencing factors on the outlet plate crown under the basic process parameters, but these factors are not independent of each other. Therefore, in order to improve the accuracy of the plate crown prediction model, a high-precision prediction model of plate crown is established by introducing the evaluation coefficient that represents the influence of single factor on plate crown and the correction coefficient that represents the effect of factor a on the evaluation coefficient of factor b. This paper takes the steel SPHC as an example, calculates the plate crown without considering the correction coefficient and the plate crown considering the correction coefficient. Then, the two calculation results are compared with the calculation results of the coupled model and the accuracy of the new model is improved after considering the correction coefficient. In general, compared with the traditional crown prediction model, the accuracy of the new model is greatly improved.