bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Two Overlooked Details in ­Leonardo da Vinci’s Adoration of the Magi
Authors: Pestilli Livio 
Published: September 2020

Abstract
This article focuses on two features of Leonardo’s Adoration of the Magi made more readable after its restoration: the old man behind the Virgin and the object painted in front of him. In contrast to previous interpretations, it is argued that the old man does not represent St. Joseph. Rather, it is St. Donatus, patron saint of the Canons Regular of St. Augustine who commissioned the altarpiece for their church of San Donato a Scopeto. If, as argued, the garment he wears is a chasuble, the object in front of him a wine vat and the vessel he holds a pyx, then the painting referenced both the theme of the Adoration of the Magi and the patron saint’s miracle of the mass while telescoping in a visual prolepsis the beginning and the end of the Christ Child’s redeeming mission.
Re-visiting autoimmunity to sodium-iodide symporter and pendrin in thyroid disease
Authors: Eleftheriadou Anna-Maria , Mehl Sebastian , Renko Kostja , Kasim Rega H , Schaefer Jasmin-Annabelle , Minich Waldemar B , Schomburg Lutz 
Published: September 2020

Objective
Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)). Both transmembrane proteins have been described as autoantigens in thyroid disease, yet the reports on autoantibody (aAb) prevalence and diagnostic usefulness are conflicting. Reasons for the inconclusive findings may be small study groups and principle differences in the technologies used.

Design
We decided to re-evaluate this important issue by establishing novel non-radioactive tests using full-length antigens and comparable protocols, and analyzing a large cohort of thyroid patients (n = 323) and control samples (n = 400).

Methods
NIS and PDS were recombinantly expressed as fusion protein with firefly luciferase (Luc). Stably transfected HEK293 cells were used as reproducible source of the autoantigens.

Results
Recombinant NIS-Luc showed iodide transport activity, indicating successful expression and correct processing. Commercial antibodies yielded dose-dependent responses in the newly established assays. Reproducibility of assay signals from patient sera was verified with respect to linearity, stability and absence of matrix effects. Prevalence of PDS-aAb was similar in thyroid patients and controls (7.7% vs 5.0%). NIS-aAb were more prevalent in patients than controls (7.7% vs 1.8%), especially in Graves’ Disease (12.3%). Neither NIS-aAb nor PDS-aAb concentrations were related to TPO-aAb or TSH-receptor-aAb concentrations, or to serum zinc or selenium status.

Conclusions
Our data highlight a potential relevance of autoimmunity against NIS for thyroid disease, whereas an assessment of PDS-aAb in thyroid patients seems not to be of diagnostic value (yet).
Coincidencia entre agenda mediática y política en las cuentas de Twitter de los 4 candidatos con más votos para la alcaldía de Quito
Authors: Cruz Jorge 
Published: September 2020

Las intervenciones de los políticos en Twitter son medios con importancia para conocer cómo se complementa el discurso. La elección de alcalde de Quito 2019 presenta una oportunidad interesante para analizar cómo se construye ese pensamiento. Esta investigación encuentra cómo los tuits pueden reflejar la relación entre la agenda política y la agenda mediática. Estas dos agendas, se cruzan -en una perspectiva multimodal- a partir de cómo los políticos crean discurso (teorías de la propiedad y prominencia de las cuestiones) y cómo los medios lo hacen.
El estudio se refiere a los cuatro primeros candidatos en las elecciones seccionales (Yunda, Maldonado, Moncayo y Montúfar). El trabajo, a partir de una revisión a los planes de trabajo y a cientos de tuits de los candidatos, genera cuantificaciones y comparaciones en las temáticas trascendentales y comunes. Los hallazgos visualizan si se modificó o no el discurso político.
TheCellVision.org: A Database for Visualizing and Mining High-Content Cell Imaging Projects
Authors: Masinas Myra Paz David , Usaj Mojca Mattiazzi , Usaj Matej , Boone Charles , Andrews Brenda J 
Published: September 2020

AbstractAdvances in genome engineering and high throughput imaging technologies have enabled genome-scale screens of single cells for a variety of phenotypes, including subcellular morphology and protein localization. We constructed TheCellVision.org, a freely available and web-accessible image visualization and data browsing tool that serves as a central repository for fluorescence microscopy images and associated quantitative data produced by high-content screening experiments. Currently, TheCellVision.org hosts ∼575,590 images and associated analysis results from two published high-content screening (HCS) projects focused on the budding yeast Saccharomyces cerevisiae. TheCellVision.org allows users to access, visualize and explore fluorescence microscopy images, and to search, compare, and extract data related to subcellular compartment morphology, protein abundance, and localization. Each dataset can be queried independently or as part of a search across multiple datasets using the advanced search option. The website also hosts computational tools associated with the available datasets, which can be applied to other projects and cell systems, a feature we demonstrate using published images of mammalian cells. Providing access to HCS data through websites such as TheCelllVision.org enables new discovery and independent re-analyses of imaging data.
Maximuma posterioriThreshold Genomic Prediction Model for Ordinal Traits
Authors: Montesinos-López Abelardo , Gutierrez-Pulido Humberto , Montesinos-López Osval Antonio , Crossa José 
Published: September 2020

AbstractDue to the ever-increasing data collected in genomic breeding programs, there is a need for genomic prediction models that can deal better with big data. For this reason, here we propose a Maximum a posteriori Threshold Genomic Prediction (MAPT) model for ordinal traits that is more efficient than the conventional Bayesian Threshold Genomic Prediction model for ordinal traits. The MAPT performs the predictions of the Threshold Genomic Prediction model by using the maximum a posteriori estimation of the parameters, that is, the values of the parameters that maximize the joint posterior density. We compared the prediction performance of the proposed MAPT to the conventional Bayesian Threshold Genomic Prediction model, the multinomial Ridge regression and support vector machine on 8 real data sets. We found that the proposed MAPT was competitive with regard to the multinomial and support vector machine models in terms of prediction performance, and slightly better than the conventional Bayesian Threshold Genomic Prediction model. With regard to the implementation time, we found that in general the MAPT and the support vector machine were the best, while the slowest was the multinomial Ridge regression model. However, it is important to point out that the successful implementation of the proposed MAPT model depends on the informative priors used to avoid underestimation of variance components.
Allelic variation in candidate genes associated with wood properties of cultivated
poplars (Populus)
Authors: Köbölkuti Zoltán Attila , Cseke Klára , Benke Attila , Báder Mátyás , Borovics Attila , Németh Róbert 
Published: September 2020

Introduction
Since Populus has veritable value as timber, plywood,
pulp, and paper, genomic research should create the sound basis for further breeding
toward desirable wood quality attributes.

Materials and methods
In this study, we addressed the need for a research methodology that initially
identifies and then characterize candidate genes encoding enzymes with wood property
phenotypic traits, toward the aim of developing a genomics-based breeding
technology.

Results
On 23 different poplar species/hybrid samples, we successfully amplified 55
primers designed on Populus trichocarpa L. Considering the
number of polymorphic sites, out of 73,206 bp, 51 SNPs and 31 indel events were found.
Non-synonymous single base mutations could be detected in number of 30, 21 out of 164
sequences were the number of minimum recombination events and 41 significant pairwise
comparisons between loci could be detected.

Discussion and conclusion
Our results provide a roadmap for a future association genetic study between
nucleotide diversity and precise evaluation of phenotype.
In-vitro and in-silico anticancer potential of taxoids from Taxus wallichiana
Zucc
Authors: Qayum Mughal , Nisar Muhammad , Rauf Abdur , Khan Imran , Kaleem Waqar Ahmad , Raza Muslim , Karim Nasiara , Saleem Munawar Ahmad , Bawazeer Saud , Uysal Sengul , Zengin Gokhan , Jahan Saqib , Ramadan Mohamed Fawzy 
Published: September 2020

Introduction
Natural products derived from medicinal plants provide beneficial cancer
chemotherapeutic drugs. Bioactive constituents from plants are explored for their
anticancer properties.

Methods
Three known compounds (deacetylbaccatin III, tasumatrol B, and taxawallin J)
were isolated from Taxus wallichiana. Compounds were
screened against four cancer cell lines, such as eA498, HepG2, NCI-H226, and MDR
2780AD. Cytotoxic activity was evaluated using MTT assay against cancer cell
lines.

Results
Tasumatrol B showed good cytotoxic activity conducted for the improvement of
inhibiting potential of these compounds against the cancer drug target protein (EGFR
tyrosine kinase enzyme). The docking study showed that all compounds have binding
affinities and interaction profile with the receptor tyrosine kinase.

Discussion
The study suggests that these compounds could be used for the discovery of novel
inhibitors against the target receptors for the treatment of cancer.
The reducing effect of agomelatine on pentylenetetrazol-induced convulsions
Authors: Demirel Esra Aciman , Erdoğan Mumin Alper , Cinar Bilge Piri , Erbas Oytun 
Published: September 2020

Introduction
Agomelatine is a potent MT1 and MT2 melatonin receptor agonist and a 5-HT2C
serotonin receptor antagonist. The purpose of this study was to show the
convulsion-reducing effect of agomelatine, in both clinical and electrophysiological
terms, in a pentylenetetrazole (PTZ)-induced experimental epilepsy model in
rats.

Methods
The anticonvulsant activity of agomelatine (25 and 50 mg/kg) was evaluated in
rat models of PTZ (35 and 70 mg/kg) and compared with the control groups.

Results
Agomelatine administration at doses of 25 and 50 mg/kg resulted in a
statistically significant decrease in convulsion scores and time to onset of myoclonic
jerks compared to the control groups. In addition, comparison of the two doses
employed showed that high-dose agomelatine (50 mg/kg) was significantly more effective
than the lower dose. In addition to previous studies, we investigated the
anticonvulsant effect of agomelatine using electroencephalogram (EEG). Administration
of agomelatine at doses of 25 and 50 mg/kg in PTZ-induced seizures caused a
significant decrease in the percentage of peak at EEG.

Discussion
Our results suggest that agomelatine has anticonvulsant activity shown in
PTZ-induced seizure model. The results also give some evidences that agomelatine can
use on epileptic seizures, but more studies are needed.
A cilostazol diabeteses betegekben is javítja az életminőséget és az alsó végtagi funkcionális kapacitást
Authors: Farkas Katalin , Kolossváry Endre , Járai Zoltán 
Published: September 2020

Absztrakt:
Bevezetés: A claudicatio intermittens jelentős negatív hatással
van a betegek életminőségére. A különböző revascularisatiós eljárások és a
noninvazív orvosi kezelések javíthatják a betegek járását. A cilostazol I.A
ajánlással rendelkezik a claudicatio intermittens kezelésére.
Célkitűzés: Vizsgálatunk célja a 3 hónapos
cilostazolkezelésnek az egészséggel kapcsolatos életminőségre és az alsó végtag
funkcionális kapacitására gyakorolt hatásának értékelése a klinikai
gyakorlatban, claudicatio intermittensben szenvedő diabeteses (DM) és nem
diabeteses (NDM) betegek körében. Módszer: A tanulmány
multicentrikus, beavatkozással nem járó vizsgálat, amelybe 812, ambuláns kezelés
alatt álló, perifériás verőérbetegségben szenvedő beteg (Fontaine II. stádium,
átlagéletkor: 67,17 év, férfi/nő: 58,25/41,75%, 318 diabeteses) került
beválasztásra, akik cilostazolkezelést kaptak (50 vagy 100 mg naponta kétszer) 3
hónapig. Az életminőséget az EQ-5D-3L-kérdőívvel, a funkcionális kapacitást a
WELCH-kérdőívvel értékeltük. A fájdalommentes és maximális járástávolságnak,
valamint a boka-kar indexnek a mérése megtörtént a vizsgálat indulásakor és a 3
hónapos kezelés után. Eredmények: A vizsgálat befejezése után
az EQ-5D-index javult (kiindulási érték: NDM –0,45 ± 0,22, DM –0,48 ± 0,23, 3.
hónap: –0,24 ± 0,18, –0,27 ± 0,19; p<0,0001), és a WELCH-pontszám szintén
szignifikánsan nőtt (kiindulási érték: NDM 20 ± 14, DM 18 ± 14; 3. hónap: 33 ±
19, 29 ± 16; p<0,0001) mindkét betegcsoportban. Mind a fájdalommentes, mind a
maximális járástávolság nőtt: NDM 59,2% (medián: 50,0%), 46,58 (medián: 40,51%),
és DM 42,85% (medián: 43,33%), 41,61% (medián: 34,68%) (p<0,001).
Következtetés: 3 hónapos cilostazolkezelés javította az
életminőséget és az alsó végtagi funkcionális kapacitást claudicatio
intermittensben szenvedő betegekben, diabetes esetén is. A WELCH-kérdőív hasznos
eszköznek bizonyult a klinikai gyakorlatban a claudicatio kezelése során a
járóképesség értékelésére. Orv Hetil. 2020; 161(38): 1637–1645.
Studi Pengaruh Anion Asetat Terhadap Kelarutan Li2CO3 sebagai Dasar Recovery Litium pada Kondisi Terlindi Asam Asetat
Authors: Wicaksono Muhamad Fajar Wicaksono Fajar , Perdana Indra , Sutijan Sutijan 
Published: September 2020

Litium karbonat, salah satu bentuk senyawa litium yang paling sering dihasilkan pada proses daur ulang baterai bekas. Pada industri proses mineral, pembentukan senyawa litium karbonat disintesis pada kondisi adanya anion-anion ikutan yang berasal dari proses pelindian. Pada beberapa dekade, penggunaan larutan pelindi anorganik mulai ditinggalkan dan beralih ke pelindi organik. Salah satu asam organik yang memberikan hasil recovery leaching tertinggi adalah asam asetat, akan tetapi pembentukan litium karbonat dalam larutan yang mengandung anion asetat sulit dilakukan yang dikarenakan efek anion asetat terhadap kelarutan litium karbonat belum teridentifikasi, Pada penelitian ini, dipelajari pengaruh anion asetat dalam pengendapan litium karbonat dan dari hasil ini didapatkan bahwa pengaruh konsentrasi asetat bersifat non linear terhadap kelarutan litium karbonat dan disimpulkan bahwa konsentrasi asetat 0,2 mol memberikan kelarutan terendah terhadap litium karbonat. Dengan informasi tersebut, maka diharapkan permasalahan recovery litium karbonat pada larutan pelindi asetat dapat terselesaikan.
Kronik Hepatit B Virüs enfeksiyonu olan hastalarda Hepatit A Virüs seroprevalansı
Authors: ÖNER Sedef Zeliha , TÜRKOĞLU Emine 
Published: September 2020

Amaç: Bu çalışmada, Kronik Hepatit B tanısı ile takipli hastaların Hepatit A seroprevalansının retrospektif olarak araştırılması ve duyarlı kişilerin aşılanması amaçlanmıştır.
Gereç ve Yöntemler: Kasım 2018–Kasım 2019 tarihleri arasında hastanemiz enfeksiyon hastalıkları polikliniğine başvuran kronik hepatit B tanılı hastaların HAV Ab-IgG sonuçları değerlendirildi. HAVAb-IgG tetkiki, ARCHITECT i2000SR analizatöründe ARCHITECT® HAVAb-IgG test kiti ile Kemilüminesan Mikropartikül İmmünoassay (CMIA) yöntemi kullanılarak araştırılmıştır. Verilerin istatistiksel analiz Statistical Package for Social Scienses (SPSS) 21 (Inc. Chicago, Illinois, ABD) istatistik paket programıyla analiz edilmiştir.
Bulgular: Kronik hepatit B tanısıyla izlenen 138 hasta değerlendirildi. Hastaların 27’sinde HAV Ab-IgG tetkiki yapılmamıştı. Çalışmaya 111 hasta dahil edildi. Hastaların 64’ü (%57,7) kadın, 47’si (%42,3) erkekti. Hastalar 15-84 yaş aralığına sahipti. Yaş ortalaması 48,01±11,86 yıl olarak tespit edildi. Anti-HAV IgG 105 (%94,6) hastada pozitif, 6 (%5,4) hastada negatifti. Anti-HAV IgG pozitif hastaların yaş ortalaması 49,25±11,31 tespit edildi. Anti-HAV IgG negatif olan hastaların 2’si (%33,3) kadın, 4’ü (%66,7) erkekti. Hastalar 15-36 yaş aralığına sahipti. Yaş ortalaması 26,16±5,16 yıl olarak tespit edildi.
Sonuç: Kronik hepatit B virüs enfeksiyonu olan hastalarda hepatit A virüs seroprevalansı %94,6 olarak bulundu. HBV enfeksiyonu olan hastalarda HAV Ab-IgG tetkiki yapılmalı ve Anti-HAV IgG negatif olan hastalar aşılama programına alınmalıdır.
Outcome of tuberculosis and diabetes mellitus coinfection: A study in a tertiary care centre in semiurban India
Authors: Ponnathota Vindhya , Sujatha Gogineni 
Published: September 2020

Tuberculosis has for a very long time been one of the major causes of morbidity and mortality globally. Diabetes mellitus is another disease which is growing into another major global challenge. Presence of diabetes increases the risk of tuberculosis by 2 to 3 times.2 sputum samples were collected from all the 202 patients for Zeihl Neelson’s staining to screen the Mycobacterium tuberculosis bacillus. Venous blood was taken for blood glycated hemoglobin and other biochemical and hematological tests.Out of these 41.6% had diabetes and 58.4% were non diabetic. The chest X-rays were severe in 51.2% patients among the TB and DM comorbid patients and 33.9% among the non diabetic patients. Poor outcome was seen in 54.8% of the cases among the DM and TB patients which in only TB patients with no diabetes, the number of cured patients was far more.There was a high incidence of diabetes among the patients with TB, which increases the morbidity and mortality among these patients. Smoking and alcoholism are preventable risk factors. So proper counselling and health education is necessary so that the patients would be able to monitor their blood sugar levels.
Introduction to 2020-3
Authors: Buch Anders 
Published: September 2020

This issue of Nordic Journal of Working Life Studies brings together four articles. The first article of this issue, Cherry Picking Disablility Rights? Swedish Disability Policy on Employment, Health and Participation, authored by Faten Nouf-Latif and colleagues, examines how Swedish disability policies are developed to meet UN Conventions on the Right of Persons with Disabilities. Focusing on a recent Swedish governmental disability policy document and legal documents, the authors ask how they describe individuals with disabilities in terms of citizens in the policy areas of health and employment?; how governmental responsibilities are formulated?; and how the policy management affects individuals’ opportunities to enjoy citizenry and participation? Using directed content analysis and theories of social risk and governance, the authors observe that the employment domain is given much more attention and focus at the cost of the policy area of health. Hard governance is predominant in relation to the employment domain, whereas governance in relation to the health domain is softer – employing abstract directives to stakeholder organizations and authorities (...)
Research and Practice on the Construction of Professional Humanities Training System from the Perspective of School-enterprise Integration
Authors: Huang Jing 
Published: September 2020

<p align="justify">From the dimensions of the integration of campus culture and corporate culture, the curriculum system of professional humanities training, the system of professional humanistic education activities, the construction of professional humanities teachers, and the evaluation system of professional humanities, the professional humanistic training system under the school-enterprise integration perspective was explored. In order to better cultivate the socialist builders and successors with the comprehensive development of moral, intellectual, physical and aesthetic education, the vocational and humanistic training of higher vocational colleges is better. </p>
A method for reducing lymphorrhea in the postoperative period after axillary lymphadenectomy for metastatic lesion in patients with skin melanoma
Authors: Yargunin S. A. , Shoyhet Y. N. , Lazarev A. F. 
Published: September 2020

Objective. Prevention of prolonged lymphorrhea, postoperative lymphocysts in patients with melanoma metastases after axillary lymph node dissection.
Material and methods. Patients with metastases of melanoma in axillary lymph nodes (n = 67) who underwent axillary lymph node dissection were studied. Patients were divided into two groups comparisons (n = 35), which, after surgical intervention in the armpit, installed an active aspiration system according to Redon and the main (n = 32), patients of which, in addition to the draining system, installed an elastic rubber ball with water, which provided additional pressure on the skin. A significant difference (p0.001) was established between the main and comparison groups in the number of hospital days spent by patients in the hospital. For a statistical comparison, the Mann-Whitney test was used, the distribution form was checked using the Kolmogorov-Smirnov test. The median and interquartile range (Me [Q25%Q75%]) were determined as measures of the average tendency and spread.
Results. In the main group, patients with lymphorrhea stopped faster, drainage was removed earlier and the average hospital stay was 3 days shorter than in patients in the comparison group, and lymphocyst formation was not observed in comparison with the comparison group in which this complication was observed 11.4%.
Discussion. The duration of patients stay in the hospital directly depended on the date of drainage removal, the time of tissue adhesion and the end of lymphorrhea, the formation of a lymphocyst in the postoperative period, which directly depended on the application of a new technique of additional pressure on the tissues besides vacuum drainage.
Conclusion. the installation of hydraulics immediately after the operation leads to a faster gluing of the separated tissues, a reduction in lymphorrhea, and, accordingly, a shorter use of drainage, early removal and discharge of the patient from the hospital, and prevention of the formation of lymphocytes with the corresponding medical and economic effect. Priority certificate No. 2019109858 dated 04/03/2019 was received for the method used.
Primary open angle glaucoma: scientometric analysis of evidence research
Authors: Borzunov Oleg Igorevich , Ponomarenko G. N. 
Published: September 2020

The article presents modern data of scientometric analysis and scientific substantiation of the introduction of the evidentiary approach to the development of the strategy of physical therapy of primary open-angle glaucoma (POAG).
Aim is to conduct a scientometric analysis of evidence-based studies on the use of therapeutic physical factors in the therapy of primary open-angle glaucoma.
Results. The paper considers the proposed mechanisms of action and the clinical effects of proven therapeutic physical factors in the therapy of POAG. Particular attention is paid to evidence-based studies on the use of magnetotherapy, electrical stimulation, laser stimulation. In the course of the comprehensive analysis, recommendations on the use of therapeutic physical factors in the treatment of patients with POAG based on evidence were suggested.
Сonclusion. An obligatory link in the therapy of patients with POAG is the analysis of existing evidence-based studies and the implementation of new quality randomized controlled clinical trials to study the effect of therapeutic physical factors on the course of POAG treatment.