bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric analysis of acute pancreatitis in Web of Science database based on CiteSpace software
Authors: Sun Wenjie , Huang Pinxian , Song Hualing , Feng Dianxu 
Published: December 2020

Abstract

Objectives:
Recent years have witnessed some controversial viewpoints in clinical and basic research, which exert a great influence on the research trend of acute pancreatitis (AP). We aimed to analyze the literature on AP by metrology, co-occurrence, co-citation, and visualization, and to explore the research status and trend in this field in the past 5 years.

Methods:
The relevant literature collected in Web of Science Core Collection (WoSCC) database from 2015 to 2019 was searched using “acute pancreatitis” as the title word, and the co-occurrence analysis of authors, institutions, countries, and keywords was carried out by using CiteSpace V. On this basis, the keywords were clustered and analyzed by using VOSviewer 1.6.8 and Carrot 2 software, and a visual map was drawn.

Results:
A total of 2035 articles were included, with an average annual volume of more than 400. The high-yield authors were mainly Chinese, among which Li WQ was the most prominent. Most of these articles were from universities and institutions of high-yielding countries including China, the United States, and India. The main sources of journals were professional journals, among which Pancreas and Pancreatology have the most literature collection volume (both over 100), including clinical and basic research. Among the funds, the National Natural Science Foundation of China and NIH were the main 2 sponsors. Disciplinary attributes involved multiple subjects such as gastroenterology, internal medicine, and surgery. Keyword co-occurrence and clustering results showed that the classification, mortality, and risk factors of AP were still more concerned, and the research trend of this disease was the molecular mechanism of the severity of AP.

Conclusions:
CiteSpace can be used to analyze the knowledge graph of AP, to show its development status initially and intuitively, and to provide a reference for topic content and its further development.
Arthroscopy versus nonoperative treatment of symptomatic femoroacetabular impingement syndrome
Authors: Kim Chul-Ho , Moon Jun-Ki , Yoon Jae Youn , Lee Sunhyung , Kim Won Jun , Kim Han Soul , Lee Soong Joon , Yoon Pil Whan 
Published: December 2020

Abstract

Background:
Presently, hip arthroscopy is a widely adopted surgical intervention for the treatment of femoroacetabular impingement (FAI). However, there is insufficient evidence regarding which between arthroscopy and nonoperative treatment is more optimal for symptomatic FAI.

Methods:
MEDLINE, Embase, Web of Science, and the Cochrane Library were systematically searched for studies that compared arthroscopy and nonoperative interventions for FAI treatment from inception to August 4, 2020. We included studies that directly compared surgical and nonsurgical treatment for symptomatic FAI and excluded those that did not use arthroscopic treatment as a surgical technique and studies performed on patients with concomitant diagnoses instead of pure FAI. We compared the following clinical outcome scores at 6 and 12 months of follow-up: International Hip Outcome Tool 33 (iHOT-33), hip outcome score (HOS), EuroQol-visual analog scale (EQ-VAS), modified Harris hip score (mHHS), and nonarthritic hip score (NAHS).

Results:
Five studies totaling 838 patients were included in the qualitative and quantitative synthesis; 382 patients underwent hip arthroscopy, and 456 patients were treated by nonoperative interventions. At 6 months of follow-up, there were no statistically significant differences in iHOT-33 ratings (mean difference [MD] = 7.92, P = .15), HOS (MD of HOS-ADL = 5.15, P = .26 and MD of HOS-Sports = 2.65, P = .79, respectively), and EQ-VAS (MD = 1.22, P = .76) between the 2 treatment strategies. At 12 months of follow-up, the arthroscopy group had a greater mean improvement in iHOT-33 score than the conservative treatment group (MD = 8.42, P = .002), but there was no difference between the groups in terms of mHHS rating (MD = −0.24, P = .83) and NAHS (MD = −2.08, P = .09).

Conclusion:
Despite arthroscopy being associated with significantly superior iHOT-33 scores after 12 months of follow-up, we were unable to discern the difference between the treatment strategies using other scoring methods, such as HOS, EQ-VAS, mHHS, and NAHS. Further studies will be needed to conclusively determine if 1 strategy is superior to the other for treating FAI.
Effect and safety of Chinese patent medicine capsules for recurrent angina pectoris after percutaneous coronary intervention
Authors: Sun Yize , Wang Zheyi , Wang Chao , Tang Zhuoran , Shi Jinyu , Zhao Haibin 
Published: December 2020

Abstract

Introduction:
Recurrent angina pectoris after percutaneous coronary intervention (PCI) is a common clinical syndrome, which seriously reduces the quality of life and health of patients, increases medical costs, and causes the risk of cardiogenic death. The efficacy of various western medicine improving angina symptoms has not been fully confirmed at the moment, whereas Chinese patent medicine capsules (CPMC) have been generally used in clinical practice due to the therapeutic efficacy and safety. This study evaluates the efficacy and safety of CPMC for stable angina after PCI, designed to provide more evidence for clinical treatment.

Methods:
This protocol was based on the previous reporting items. We will search 3 English databases (PubMed, Excerpta Medica Database, and the Cochrane Library) and 3 Chinese databases (China Network Knowledge Infrastructure, Wan Fang Database, and Chinese Biomedicine) until January 2020. RCTs to evaluate the efficacy and safety of CPMC for recurrent stable angina pectoris after PCI will be included. The primary outcome will be assessed by major adverse cardiovascular events and angina attack frequency. We will use the criteria provided by Cochrane risk of bias tool for quality evaluation and risk assessment, and use the Revman 5.3 for meta-analysis.

Ethics and Dissemination:
Ethical approval is not required for systematic review and meta-analysis. The results of this review will be disseminated in a peer-review journal.

PROSPERO registration number:
CRD42020164005.
Bringing prevost's sign into the third dimension: Artificial intelligence estimation of conjugate gaze adjusted length (CGAL) and correlation with acute ischemic stroke
Authors: Maresky Hillel S. , Rootman Joseph M. , Klar Miriam M. , Levitt Max , Kossar Alexander P. , Zucker David , Glazier Michael , Kalmanovich-Avnery Shani , Aviv Richard , Ertl-Wagner Birgit , Tal Sigal 
Published: December 2020

Abstract
Conjugate gaze deviation is associated with acute ischemic stroke (AIS), although previously only measured on a 2D plane. The current study evaluates 3D imaging efficacy to assess conjugate gaze deviation and correlate direction and strength of deviation to neuro-clinical findings.
A retrospective analysis of 519 patients who had CT scans for suspected AIS at our institution. Direction and angle of eye deviation were calculated based on 2D axial images. Volumetric reconstruction of CT scans allowed for calculation of 3D conjugate gaze adjusted length (CGAL). Angle, direction, and vector strength of both 2D and 3D scans were calculated by an artificial intelligence algorithm and tested for agreement with hemispheric ischemia location. CGAL measurements were correlated to NIHSS scores. Follow up MRI data was used to evaluate the sensitivity and specificity of CGAL in the identification of AIS.
The final analysis included 122 patients. A strong agreement was found between 3D gaze direction and hemispheric ischemia location. CGAL measurements were highly correlated with NIHSS score (r = .72, P = .01). A CGAL >0.25, >0.28, and >0.35 exhibited a sensitivity of 91%, 86%, and 82% and specificity of 66%, 89%, and 89%, respectively, in AIS identification. A CGAL >0.28 has the best sensitivity-specificity balance in the identification of AIS. A CGAL >0.25 has the highest sensitivity.
Given CED's correlation with NIHSS score a 1/4 deviation in the ipsilateral direction is a sensitive ancillary radiographic sign to assist radiologists in making a correct diagnosis even when not presented with full clinical data.
Contraceptive and reproductive health practices of unmarried women globally, 1999 to 2018
Authors: Wang Meng-yao , Temmerman Marleen , Zhang Wei-hong , Fan Yu , Mu Yi , Mo Si-ping , Zheng Ai , Li Jin-ke 
Published: December 2020

Abstract

Background:
Premarital sex practices and contraceptive prevalence rate (CPR) among unmarried women worldwide remain unclear, even though unmarried women tend to have multiple sex partners over time, which makes their sexual behaviors particularly important to the sexual and reproductive health of society more broadly.

Methods:
We searched the MEDLINE, PubMed, and Google Scholar databases for relevant articles published between January 1, 1999 and December 31, 2018. Data on prevalence of premarital sexual intercourse, use of highly prevalent contraceptive methods, as well as CPR overall and at first sexual intercourse were extracted and estimated using a DerSimonian– Laird random effects model.

Results:
Of the 3918 articles identified, 37 covering 19 countries were included. The estimated overall prevalence of premarital sexual intercourse was 41.9% (95%CI 34.2–49.6%). Pooled CPR was 57.0% (95%CI 44.3–69.8%) overall and 57.6% (95% CI 39.5– 75.6%) at first intercourse. The overall prevalence of condom use was 51.2% (95%CI 42.7–59.7%), followed by oral contraceptives (20.5%, 95%CI 13.7–27.3%), withdrawal (12.7%, 95%CI 9.4–15.9%), and rhythm (12.1%, 95%CI 6.7–17.4%).

Conclusion:
The findings of this global study indicate worrying trends in unprotected intercourse and contraceptive practices, suggesting the need for greater attention and resources aimed at educating unmarried adolescent women about sexual and reproductive health.

Systematic review registration number:
CRD42019132736.
Gemcitabine, cisplatin, and dexamethasone and ifosfamide, carboplatin, and etoposide regimens have similar efficacy as salvage treatment for relapsed/refractory aggressive lymphoma
Authors: Mi Mi , Zhang Caijiao , Liu Zijian , Wang Ye , Li Juan , Zhang Liling 
Published: December 2020

Abstract
In this study, our aim was to compare the efficacy and toxicity profiles of gemcitabine, cisplatin, and dexamethasone (GDP) and ifosfamide, carboplatin, and etoposide (ICE) regimens in the salvage treatment of relapsed/refractory lymphoma. A total of 110 patients with refractory/relapsed classical Hodgkin lymphoma (n = 22) or non-Hodgkin lymphoma (n = 88) who received GDP or ICE salvage regimens from January 2011 to July 2018 were retrospectively analyzed. Of the 110 patients, 50 patients received GDP, and 60 patients received ICE. The response could be evaluated in all patients. In the GDP group, 30 (60.0%) patients achieved overall response rate (ORR), and in the ICE group, the ORR was 56.6%. Of the classical Hodgkin lymphoma patients, the ORR were 72.8% and 54.6% in the GDP and ICE groups, respectively. Of the non-Hodgkin lymphoma patients, the ORR were 56.4% and 57.1% in the GDP and ICE groups, respectively. Grade I-II toxicity occurred in 16 (32.0%) patients in the GDP group and 18 patients (30.0%) in the ICE group; 14 (28.0%) patients had Grade III-IV toxicity in the GDP group, as did 20 (33.3%) patients in the ICE group. As a result, both GDP and ICE regimens are suitable for the treatment of recurrent/refractory lymphoma. The overall adverse reactions of both regimens are acceptable.
The association study of Apolipoprotein E polymorphisms and chronic obstructive pulmonary disease in the Chinese population
Authors: Zhang Yuan , Li Xiao-hui , Zhou Yu-tian , Xiang Lu , Xiao Meng , Guo Jian-shu , Zhang Jing-wei , Chen Guo 
Published: December 2020

Abstract
Chronic obstructive pulmonary disease (COPD) patients have increased cardiovascular morbidity and mortality. Apolipoprotein E (ApoE) is involved in chronic inflammation which is the common characteristic of emphysema and cardiovascular disease. ApoE polymorphisms are associated with cardiovascular disorders and atherosclerosis. There is no report about the association between ApoE polymorphism and COPD.
A total of 480 COPD patients and 322 controls who were unrelated Chinese Han individuals were enrolled. Rs429358 and rs7412 were genotyped and the associations between ApoE polymorphisms and COPD risk were analyzed by logistic regression analysis. Online software SHEsis were applied to perform linkage disequilibrium (LD) and haplotypes analysis. The interactions of ApoE and environmental factor on COPD susceptibility was analyzed by software MDR3.0.2.
No significant association was found between rs429358, rs7412 and COPD under different genetic models. Rs429358 and smoking formed the best model in the MDR analysis. The frequency of E2/E2 phenotype was the lowest in 2 groups. E3/E3 was the most common phenotype, accounting for 69.8% of COPD patients and 68.9% of controls. No statistically difference was identified between the cases and controls under different phenotypes.
This was the first genetic association study between ApoE and COPD. No positive association was found in the Chinese Han population. Rs429358 and smoking status existed significant interaction, indicating that both of ApoE and smoking may be involved in the development of COPD disease.
Unicompartmental knee replacement and high tibial osteotomy for medial unicompartmental knee osteoarthritis
Authors: Yin Yongqiang , Zhang Xu , Zhang Kaiming , He Xiang 
Published: December 2020

Abstract

Background:
Many clinical studies have been published in the literature to compare the outcomes of unicompartmental knee replacement (UKR) and high tibial osteotomy (HTO), but reached different conclusions. Therefore, the relative merits and demerits of these 2 procedures remain under debate. The purpose of the present protocol was to design a retrospective comparative study to further investigate the clinical effectiveness of HTO compared to UKR in the medial unicompartmental osteoarthritis of knee patients.

Methods:
This is an observational retrospective research, which prospectively collected the data from several surgeons in our center and utilized the above 2 methods to treat the unicompartmental osteoarthritis of knee. In our single hospital, we reviewed unicompartmental knee osteoarthritis patients treated using UKR or HTO from June 2016 to February 2018. For the HTO, its criteria included:
For the UKR, its inclusion criteria contained
In our cohorts, the clinical investigations of the knee were composed of the objective parameters, which were recorded and then documented through utilizing the Function Score and Orthopedic American Knee Society Knee Score. The extra clinical findings evaluated involved operative time, postoperative requirements of blood transfusion, possible postoperative complications, as well as the range of motion.

Conclusion and discussion:
The results of this study will provide clinical evidence on appropriate surgical treatment for patients with medial unicompartmental knee osteoarthritis.

Trial registration:
This study protocol was registered in Research Registry (researchregistry6152).
A randomized, multi-center, open-label study to compare the safety and efficacy between afatinib monotherapy and combination therapy of afatinib and HAD-B1 for the locally advanced or metastatic NSCLC patients with EGFR mutations
Authors: Song Si-Yeon , Ha Su-Jeong , Park Ji-Hye , Park So-Jung , Shin Seong Hoon , Oak Chulho , Choi Jun-Yong , Yoon Seong Woo , Kim Jung-A , Yoon Seong Hoon , Son Ji Woong , Kim Seung Joon , Yoo Hwa-Seung 
Published: December 2020

Abstract

Background:
Afatinib is an epidermal growth factor receptor - tyrosine kinase inhibitor (EGFR-TKI) with proven efficacy for treating patients with advanced or metastatic non-small cell lung cancer (NSCLC). Unfortunately, responses are limited by acquired resistance. Because traditional Korean medicine may have synergistic effects when combined with chemotherapy or radiotherapy, the aim of our study is to elucidate the efficacy and safety of afatinib plus HangAmDan-B1 (HAD-B1) combination therapy in the treatment of patients with NSCLC, as well as EGFR mutations, who need afatinib therapy.

Methods/design:
This study is a randomized, multi-center, open clinical trial. A total of 142 eligible subjects, recruited at 8 centers, are randomly assigned to take Afatinib (20–40 mg) ± HAD-B1 (0.972 g/day) for 16 weeks. In the test group, HAD-B1 and afatinib will be used in combination. The primary outcome is a comparison of starting dose maintenance rate as well as the disease control rate (DCR) between afatinib monotherapy and afatinib plus HAD-B1 combination therapy in patients with local advanced or metastatic (Stage IIIA, B, C/IV) NSCLC. Secondary outcomes are the Progression Free Survival (PFS), Time to progression (TTP), Overall survival rate, ORR based on RESIST 1.1, tumor size reduction, health-related quality of life (HRQoL), and Tumor marker.

Discussion:
The result of this clinical trial will provide evidence for the efficacy and safety of using HAD-B1 in the treatment of EGFR-positive patients with locally advanced or metastatic NSCLC who require afatinib therapy.

Trial registration:
Clinical Research Information Service (CRIS), Republic of Korea (ID: KCT0005414), on September 23, 2020.
Effects of glucagon-like peptide 1 receptor agonists and sodium glucose cotransporter 2 inhibitors on major adverse cardiovascular events in type 2 diabetes by race, ethnicity, and region
Authors: Qiu Mei , Ding Liangliang , Wei Xubin , Wei Wei , Zhou Hairong 
Published: December 2020

Abstract

Background:
The effects of sodium-glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists on major adverse cardiovascular events (MACE) in type 2 diabetic subgroups defined by race, ethnicity, and region are unestablished.

Methods:
We searched PubMed and Embase for related randomized controlled trials. We conducted random-effects meta-analysis, stratified by drug class, on MACE in various subgroups defined by 3 factors of interest (ie, race, ethnicity, and region) to estimate pooled hazard ratio (HR) and 95% confidence interval. Random-effects meta-regression was conducted to evaluate the differences between 2 drug classes.

Results:
We included 11 randomized controlled trials for pooled analysis. Compared with placebo, SGLT2is and GLP-1 RAs significantly reduced the risk of MACE (HR ranged from 0.76 to 0.93) in most diabetic subgroups defined by 3 factors of interest. The 2 drug classes did not significantly reduced this risk in the Black race group (HR 0.92, 95% confidence interval 0.70–1.20). The effect of the 2 drug classes on MACE was not significantly different in all diabetic subgroups of interest (P-value for subgroup differences ranged from .101 to .971).

Conclusions:
SGLT2is and glucagon-like peptide 1 receptor agonists can significantly reduce the risk of MACE in most type 2 diabetic subgroups defined by race, ethnicity, and region, whereas they fail to do it in Black individuals.
Aerobic, resistance and combined training for adults with chronic kidney disease
Authors: Zeng Rong , Lai Honghao , Li Zhuoyan , Chen Beibei , Wang Lu , Zhang Yali 
Published: December 2020

Abstract

Background:
Chronic kidney disease (CKD) as a disease that poses a great threat to human health, which has become a public health issue of great concern. Studies have found that exercise training has a positive effect on improving the condition of chronic kidney disease. We will conduct a network meta-analysis to assess the effects of aerobic training, resistance training and combined aerobic and resistance training in treating CKD patients.

Methods:
We will search PubMed, EMBASE, Medline, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of science to identify randomized control trails (RCTs) that assessed the effect of different exercise training for CKD patients. Cochrane Handbook will be used to evaluate the risk of bias of included articles. We will use Stata or R software to perform data analysis.

Results and Conclusion:
Our systematic review and network meta-analysis will be the first study that investigates the effect of different exercise training for CKD patients, and will provide evidence for management of chronic kidney disease.

Ethics and dissemination:
The data involved in this study are from published articles. For this reason, there is no need for ethical approval or patient consent.

Trial registration:
the registration number was: CRD42020157280
Infrared thermography in the diagnosis of musculoskeletal injuries
Authors: Li Xiaoyu , Zhang Yajun , Sun Haiju , Jiang Yongliang , Lou Jiali , He Xiaofen , Fang Jianqiao 
Published: December 2020

Abstract

Background:
Musculoskeletal injuries (MSDs) have become a major public health problem worldwide. Current diagnosis techniques for MSDs are often associated with radiation exposure, expensive cost, or contraindication. Infrared thermography (IRT) is becoming a proposed tool to assist in diagnosing MSDs, but current evidence is inconclusive. Thus, herein we aimed to evaluate the diagnostic accuracy of IRT for MSDs.

Methods:
We will search EMBASE, MEDLINE, EBSCO, Cochrane Library, SCOPUS, Web of Science, CNKI, SinoMed, and Wangfang. Two researchers will independently screen eligible studies. Study quality will be evaluated based on the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Data synthesis will be completed using STATA 14.0 software. A bivariate random-effects analysis will be utilized to estimate the pooled estimation of the diagnostic odds ratio (DOR) and the summary receiver operating characteristics (SROC) curve. Subgroup analyses will be performed to determine heterogeneity sources.

Results:
This systematic review and meta-analysis will provide reliable evidence about the diagnostic accuracy of IRT for MSDs.

Conclusion:
The conclusion of this study will be published in a peer-reviewed journal.

Ethics and Communication:
Given that this is a systematic review of published research, patient consent and ethical approval are not relevant. The findings of this study will be disseminated through conference presentations and publication in peer-reviewed journals.

Prospero registration number:
CRD42020184867.