bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the fuzzy predictors of stress at work
Authors: Vatankhah Sanaz , Bouzari Mona , Safavi Homayoun Pasha 
Published: May 2020

Purpose
This study aims to identify and rank the significant determinants of stress among tourism and hospitality employees.

Design/methodology/approach
A mixed-method approach is used to identify and rank workplace stressors. Particularly, the synthesis of relative literature and interview with the panel of experts resulted in the preliminary identification of workplace stressors. Underpinned by fuzzy theory, in addition, the fuzzy analytical hierarchy process is used to rank identified criteria and relative sub-criteria.

Findings
Results of three-wave investigation lead to an index comprising key components and weighted ranking of workplace stressors in the tourism and hospitality industry with job characteristics as the most important criteria and mental demand as the most salient sub-criteria influencing stress at work.

Research limitations/implications
The pattern of findings enhances the current knowledge regarding significant workplace stressors in the tourism and hospitality industry.

Practical implications
Compositional framework and the weight-based ranking of identified components may act as a source of strategic solution for managers to reduce and manage stress among employees.

Originality/value
Workplace stressors have attracted considerable research attention, however, no general consensus yet exists among scholars and practitioners conferring to the key composition and relative importance of workplace stressors.
The need for exercise in exergaming perspective of the uses and gratifications theory
Authors: Pham Thi Tuan Linh , Huang Han-Chung , Cheng T.C.E. , Wong May-Kuen , Liao Yen-Ni , Yang Ya-Hui , Teng Ching-I 
Published: May 2020

PurposePlaying exergames may resemble doing conventional exercise and thus has the potential to enhance users’ health. However, no study has yet examined whether and how a need for exercise impacts users’ intention to continuously play exergames, i.e. continuance intention and its antecedents. We developed a model grounded in the uses and gratifications theory (UGT) to address this issue.Design/methodology/approachWe recruited 583 participants to play exergames and collected their psychological responses and physical information. Structural equation modeling (SEM) was used to test the hypotheses.FindingsWe found that health consciousness and perceived exercise benefits are positively related to a need for exercise, which is, in turn, positively related to continuance intention. Moreover, perceived exergame similarity with exercise strengthens the positive link between the need for exercise and continuance intention.Originality/valueThis is the first study using the UGT to explain the underlying mechanism linking health consciousness to continuance intention in the playing of exergames. In addition, we introduced the need for exercise as a novel construct in this study. Our findings provide insights to managers on incorporating health-related features into their exergame products to motivate users' engagement in playing exergames.
Downregulation of lncRNA‐HEIH curbs esophageal squamous cell carcinoma progression by modulating miR‐4458/PBX3
Authors: Wang Dawei , You Dong , Pan Yinghua , Liu Peiji 
Published: May 2020

BackgroundLong non‐coding RNAs (lncRNAs) have been found to play a specific part in the development of esophageal squamous cell carcinoma (ESCC), except for lncRNA HEIH. Here, we aimed to discover the molecular mechanisms of HEIH in ESCC.MethodsWe detected the expression level of HEIH and miR‐4458 in ESCC tissues and cells using qRT‐PCR assay. A dual luciferase reporter assay was used to check the relationship between HEIH, miR‐4458 or PBX3. Counting Clock Kit‐8 (CCK‐8) assay and transwell assay were used to detect ESCC cell proliferation and invasion capability. Western blot analysis was used to measure the protein expression level of PBX3.ResultsHEIH was confirmed to be upregulated in both ESCC tissues and cell lines. Inversely, there was a downregulation of miR‐4458 in ESCC tissues and cell lines. Functionally, we noticed that depletion of HEIH restrained ESCC cell viability, and invasion capability. Moreover, PBX silencing was found to restrain ESCC cell progression, while miR‐4458 or HEIH vector both could alleviate its suppressive effect.ConclusionsThe present study clarified that HEIH regulated ESCC progression by suppressing miR‐4458 and upregulating PBX3. Our findings suggested that HEIH could be a possible therapeutic target for ESCC treatment.
Effects of Prazosin on Provoked Alcohol Craving and Autonomic and Neuroendocrine Response to Stress in Alcohol Use Disorder
Authors: Milivojevic Verica , Angarita Gustavo A. , Hermes Gretchen , Sinha Rajita , Fox Helen C. 
Published: May 2020

BackgroundChronic alcohol use results in changes to stress biology and autonomic arousal contributing to acute alcohol withdrawal symptoms, neuroendocrine tolerance of the hypothalamic–pituitary–adrenal axis responses, high stress‐induced craving, and risk of alcohol relapse. Thus, stress coping and recovery from alcohol during early abstinence may be jeopardized by such stress system dysfunction. Significant preclinical evidence suggests that noradrenergic disruption may contribute to these alcohol‐related stress arousal changes and that alpha‐1 adrenergic antagonists, such as prazosin, may normalize these stress system adaptations and reduce alcohol intake. Thus, we hypothesized that prazosin would reduce stress‐induced craving and improve neuroendocrine and autonomic response to stress and alcohol cue exposure during early abstinence. We secondarily also assessed the role of lifetime anxiety disorders on these prazosin effects.MethodsForty inpatient treatment‐seeking alcohol‐dependent individuals were randomly assigned to receive placebo (n = 18) or 16 mg/d, T.I.D., prazosin (n = 22) in a double‐blind manner, titrated over 2 weeks. In weeks 3 to 4 after achieving full dose, patients were exposed to 3 5‐minute personalized guided imagery conditions (stress cue, alcohol cue, neutral/relaxing cue), on 3 consecutive days in a random, counterbalanced order. Alcohol craving, anxiety, heart rate, cortisol, and adrenocorticotropic hormone (ACTH) levels were assessed at baseline, following imagery and at repeated recovery timepoints.ResultsPrazosin reduced stress cue–induced alcohol craving (p < 0.05) and stress‐ and alcohol cue–induced anxiety (p < 0.05) and increased heart rate responses in all imagery conditions (p < 0.05). Prazosin lowered basal cortisol and ACTH (p’s < 0.05) and attenuated stress cue–induced rises in cortisol (p < 0.05) versus placebo. Finally, in those without lifetime anxiety disorder, the placebo group showed stress‐ and alcohol cue–induced increases in cortisol (p’s < 0.05), while the prazosin group did not.ConclusionsPrazosin may attenuate stress cue–induced alcohol craving and anxiety during early abstinence while improving adrenergic and stress system function, effects which are independent of a history of lifetime anxiety disorders.
The hermit crab–shell relationship through the lens of interaction networks: The use of network metrics and species role across communities
Authors: da Silva Alexandre R. , Rodrigues Gabriel F.B. , Lima Daniel , Cobo Valter J. , da Costa Rogério C. , Castilho Antonio L. 
Published: May 2020

AbstractHermit crabs are among the most unique crustaceans because they have a non‐calcified pleon, and they often use empty gastropod shells for shelter and protection. The lack of an adequate shell impacts their growth, reproduction and other population features especially because the shell resource might not be found for the entire population or community. This study focuses on the relationship between hermit crabs and their shells using network metrics. We analysed the nestedness, modularity, network specialisation, species specialisation and species role in eight hermit crab communities from two different types of substrate (rock and soft bottom). Most of these communities had a modular and non‐nested pattern. Some communities presented different specialisation levels in terms of resource use (generalist or specialist) with species showing different roles across communities. These patterns could be related to the intra‐/interspecific competition mechanism and by the resource (shell) usage pattern in the different regions. According to species roles, some species characterised as connectors can be addressed as conservation targets. The network approach in hermit crab/shell relationship proved to be an important tool in assessing their interaction in a community level.
Differences in the immunosurveillance pattern associated with DNA mismatch repair status between right‐sided and left‐sided colorectal cancer
Authors: Kanno Hiroki , Miyoshi Hiroaki , Yoshida Naohiro , Sudo Tomoya , Nakashima Kazutaka , Takeuchi Mai , Nomura Yoriko , Seto Masao , Hisaka Toru , Tanaka Hiroyuki , Okuda Koji , Akagi Yoshito , Ohshima Koichi 
Published: May 2020

AbstractTumor location and immunity play important roles in the progression of colorectal cancer (CRC). This study aimed to investigate the differences in the immunosurveillance pattern between right‐ and left‐sided CRC and analyze their association with clinicopathologic features, including mismatch repair (MMR) status. We included surgically resected stage II/III CRC cases and evaluated the immunohistochemical findings of HLA class I, HLA class II, programmed cell death‐ligand 1 (PD‐L1), PD‐1, CTLA‐4, CD3, CD4, CD8, TIA‐1, T‐bet, GATA3, RORγT, Foxp3, and CD163. A total of 117 patients were included in the analyses; of these, 30 and 87 had right‐ and left‐sided cancer, respectively. Tumor immunity varied according to the tumor location in the overall cohort. Analysis of the tumors excluding those with DNA mismatch repair (MMR) deficiency also revealed that tumor immunity differed according to the tumor location. In right‐sided colon cancer (CC), high expression of Foxp3 (P = .0055) and TIA‐1 (P = .0396) were associated with significantly better disease‐free survival (DFS). High CD8 (P = .0808) and CD3 (P = .0863) expression tended to have better DFS. Furthermore, in left‐sided CRC, only high PD‐L1 expression in the stroma (P = .0426) was associated with better DFS. In multivariate analysis, high Foxp3 expression in right‐sided CC was an independent prognostic factor for DFS (hazard ratio, 7.6445; 95% confidence interval, 1.2091‐150.35; P = .0284). In conclusion, the immunosurveillance pattern differs between right‐ and left‐sided CRC, even after adjusting for MMR deficiency.
Long‐term neural regeneration following injury to the peroneal branch of the sciatic nerve in sheep
Authors: Roballo Kelly C.S. , Burns Daniel T. , Ghnenis Adel B. , Osimanjiang Wupu , Bushman Jared S. 
Published: May 2020

AbstractPeripheral nerves (PNs) are frequently injured as a result of trauma or disease. Development of therapies to regenerate PNs requires the use of animal models, typically beginning in rodents and progressing to larger species. There are several large animal models of PN regeneration that each has their benefits and drawbacks. Sheep have been used in PN studies due to their similarities in body weight to humans and the ease and lesser expense in their care and housing relative to other species. We have investigated the use of sheep for studies of PN regeneration and have developed and tested an injury model in the peroneal branch of the sciatic nerve. Three experimental groups were tested on mature sheep: a bisection; a 5‐cm reverse autograft; and sham surgery. Protocols were developed for the post‐operative care for animals with this injury, and regeneration was tracked for extended time points via compound muscle action potentials (CMAPs) and endpoint assessments of nerve morphometry, muscle mass and muscle fibrosis. Results indicate the practical viability of this PN injury model and show distinctions in the degree and rate of regeneration between bisection and reverse autograft that persisted 14 months. This long‐term study shows bisections lead to significantly improved CMAPS and muscle mass and lesser muscle fibrosis as compared to reverse autograft. The persistence of these discernable changes between two relatively similar experimental groups out to extended time points is an indication of the sensitivity of this nerve section and its potential applicability for comparative studies.
COVID‐19 and herpes zoster co‐infection presenting with trigeminal neuropathy
Authors: Ferreira A. C. A. de F. , Romão T. T. , Macedo Y. S. , Pupe C. , Nascimento O. J. M. ,   Fellow of the American Academy of Neurology (FAAN)
Published: May 2020

BackgroundVaricella‐zoster virus (VZV) is a human neurotropic virus that remains in a latent state within ganglionic neurons throughout the entire neuroaxis after the primary infection. When herpes zoster (HZ) leads to trigeminal involvement, the ophthalmic division is the most implicated. COVID‐19 has emerged as a viral cause of severe acute respiratory syndrome that has spread all over the world in the last months. Co‐infection with COVID‐19 and other viruses has been reported, but sparsely, and involving the respiratory viruses.MethodsThe case of a co‐infection of COVID‐19 with VZV is reported, and the literature reviewed.ResultsA 39‐year‐old immunocompetent man presented with oligosymptomatic infection with COVID‐19, which evolved to left facial HZ, affecting the three divisions of the trigeminal nerve. The co‐infection was remotely registered, being the respiratory viruses, especially influenza, the most commonly cited association. However, the present case illustrates the emergence of a latent virus infection, which might be favored by the inflammatory response to the former agent (COVID‐19). This reaction ascended from the nasal cavity, where trigeminal branches are also placed.ConclusionsThe emergence of latent VZV infection in this rare presentation might illustrate an effect, at least locally, of COVID‐19. This virus possibly induced a retrograde reactivation of VZV in a young immunocompetent patient.
Exploring movement patterns and changing distributions of baleen whales in the western North Atlantic using a decade of passive acoustic data
Authors: Davis Genevieve E. , Baumgartner Mark F. , Corkeron Peter J. , Bell Joel , Berchok Catherine , Bonnell Julianne M. , Bort Thornton Jacqueline , Brault Solange , Buchanan Gary A. , Cholewiak Danielle M. , Clark Christopher W. , Delarue Julien , Hatch Leila T. , Klinck Holger , Kraus Scott D. , Martin Bruce , Mellinger David K. , Moors‐Murphy Hilary , Nieukirk Sharon , Nowacek Douglas P. , Parks Susan E. , Parry Dawn , Pegg Nicole , Read Andrew J. , Rice Aaron N. , Risch Denise , Scott Alyssa , Soldevilla Melissa S. , Stafford Kathleen M. , Stanistreet Joy E. , Summers Erin , Todd Sean , Van Parijs Sofie M. 
Published: May 2020

AbstractSix baleen whale species are found in the temperate western North Atlantic Ocean, with limited information existing on the distribution and movement patterns for most. There is mounting evidence of distributional shifts in many species, including marine mammals, likely because of climate‐driven changes in ocean temperature and circulation. Previous acoustic studies examined the occurrence of minke (Balaenoptera acutorostrata) and North Atlantic right whales (NARW;Eubalaena glacialis). This study assesses the acoustic presence of humpback (Megaptera novaeangliae), sei (B. borealis), fin (B. physalus), and blue whales (B. musculus) over a decade, based on daily detections of their vocalizations. Data collected from 2004 to 2014 on 281 bottom‐mounted recorders, totaling 35,033 days, were processed using automated detection software and screened for each species' presence. A published study on NARW acoustics revealed significant changes in occurrence patterns between the periods of 2004–2010 and 2011–2014; therefore, these same time periods were examined here. All four species were present from the Southeast United States to Greenland; humpback whales were also present in the Caribbean. All species occurred throughout all regions in the winter, suggesting that baleen whales are widely distributed during these months. Each of the species showed significant changes in acoustic occurrence after 2010. Similar to NARWs, sei whales had higher acoustic occurrence in mid‐Atlantic regions after 2010. Fin, blue, and sei whales were more frequently detected in the northern latitudes of the study area after 2010. Despite this general northward shift, all four species were detected less on the Scotian Shelf area after 2010, matching documented shifts in prey availability in this region. A decade of acoustic observations have shown important distributional changes over the range of baleen whales, mirroring known climatic shifts and identifying new habitats that will require further protection from anthropogenic threats like fixed fishing gear, shipping, and noise pollution.
A synbiotic marine oligosaccharide microcapsules for enhancing Bifidobacterium longum survivability and regulatory on intestinal probiotics
Authors: Chang Liuyi , Wang Peng , Sun Shujuan , Shen Zhaopeng , Jiang Xiaolu 
Published: May 2020

SummaryA novel synbiotic multiparticulate microparticle containing alginate oligosaccharide (AOS), chitosan oligosaccharide (COS) and Bifidobacterium longum CICC 6259 was produced in the current study to expand the synbiotic industrial applications. The influences of these treatments on encapsulation yield, size, morphology, protective effect and stability of microcapsules and on mice gut microbiome were studied in vitro and in vivo. In vitro experiments detected no significant difference (P > 0.05) in encapsulation yield with different types of microcapsules. However, the microcapsule diameter of marine oligosaccharide was approximately 60 μm greater, and these microcapsules increased the number of surviving cells by more than 3 log cfu/g after treatment with simulated gastrointestinal juices, compared to basic alginate microcapsules. In vivo, these microcapsules significantly increased the content of Bifidobacterium and Lactobacillus and reduced the content of Enterococcus and Escherichia in mice gut microbiome. Marine oligosaccharide probiotic microcapsules are promising as a novel functional food ingredient.
FLAER‐negative CD15+ neutrophils can be used for the simplified screening of suspected PNH cases
Authors: Semchenkova Alexandra , Kashpor Svetlana , Verzhbitskaya Tatiana , Borisov Vyacheslav , Illarionova Olga , Fechina Larisa , Maschan Alexey , Novichkova Galina , Popov Alexander 
Published: May 2020

AbstractBackgroundThe flow cytometry analysis of GPI‐linked proteins on red blood cells and leukocytes is crucial for paroxysmal nocturnal hemoglobinuria (PNH) diagnostics. However, the commonly used multicolor panels cannot be implemented in low‐resourced hematology laboratories. In order to develop a simple prediagnostic test for PNH screening, we analyzed the diagnostic accuracy of the two‐color (FLAER/CD15) detection of GPI‐deficient neutrophils.MethodsWe reanalyzed multicolor data set of 1594 peripheral blood samples of patients screened for PNH applying only two markers (FLAER/CD15). The quantitative positivity/negativity was reported. Then, these results were compared in a blinded manner with previously obtained multicolor data from the same samples.ResultsAmong the 1594 samples included in the study, 507 samples were PNH‐positive by the multicolor assay. The two‐color method revealed 510 PNH‐positive samples. The detailed examination of this discrepancy revealed 12 false‐positives and 9 false‐negatives. Therefore, FLAER/CD15 screening method displayed 98.90% of the diagnostic specificity and 98.22% of the sensitivity.ConclusionThis simple two‐color evaluation of FLAER‐negative neutrophils is a highly effective screening test for PNH. Although this approach is not intended to replace the multicolor diagnostic procedure, it could minimize the number of patients requiring a conventional multicolor flow cytometric assay.
Identifying community chronic kidney disease risk profile utilising general practice clinical records and spatial analysis: approach to inform policy and practice
Authors: Bagheri Nasser , Pearce Scott , Mazumdar Soumya , Sturgiss Elizabeth , Haxhimolla Hodo , Harley David 
Published: May 2020

AbstractBackgroundChronic kidney disease (CKD) causes a significant health burden in Australia, and up to 50% of Australians with CKD remain undiagnosed.AimsTo estimate the 5‐year risk for CKD from general practice (GP) clinical records and to investigate the spatial variation and hot spots of CKD risk in an Australian community.MethodA cross‐sectional study was designed using de‐identified GP clinical data recorded from 2010 to 2015. A total of 16 GP participated in this study from West Adelaide, Australia. We used health records of 36 565 patients aged 35–74 years, with no prior history of CKD. The 5‐year estimated CKD risk was calculated using the QKidney algorithm. Individuals' risk score was aggregated to Statistical Area Level 1 to predict the community CKD risk. A spatial hotspot analysis was applied to identify the communities with greater risk.ResultsThe mean estimated 5‐year risk for CKD in the sample population was 0.95% (0.93–0.97). Overall, 2.4% of the study population was at high risk of CKD. Significant hot spots and cold spots of CKD risk were identified within the study region. Hot spots were associated with lower socioeconomic status.ConclusionsThis study demonstrated a new approach to explore the spatial variation of CKD risk at a community level, and implementation of a risk prediction model into a clinical setting may aid in early detection and increase disease awareness in regions of unmet CKD care.
Clinical deterioration and hospital‐acquired complications in adult patients with isolation precautions for infection control: A systematic review
Authors: Berry Debra , Wakefield Erin , Street Maryann , Considine Julie 
Published: May 2020

AbstractAimTo review and synthesize literature examining clinical deterioration and hospital‐acquired complications in adult patients with isolation precautions for infection control.BackgroundIsolation precautions are a common infection prevention and control strategy which may have impact on safety and quality of care.DesignThe Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines guided this systematic review, which was registered with PROSPERO [CRD42019131573].Data sourcesA search of Medline, Embase, and Cumulative Index to Nursing and Allied Health Literature was conducted for studies published in English up to 5 April 2019.Review methodsRisk of bias was determined using Critical Appraisal Skills Program tools. Quality appraisal was performed using the Grades of Recommendation, Assessment, Development, and Evaluation approach. The primary outcomes of interest were clinical deterioration events and hospital‐acquired complications. In‐hospital death and hospital length of stay were secondary outcomes. Data were synthesized using a narrative approach.ResultsThe search yielded 785 citations after removal of duplicates, of which, six studies were relevant. Certainty of evidence for outcomes of interest was low to very low.ConclusionThere is no strong evidence that adult medical and surgical ward patients in isolation precautions for infection control are more or less likely to experience clinical deterioration or hospital‐acquired complications.Impact
What problem did the study address?

Are patients in isolation precautions more likely to experience clinical deterioration or hospital‐acquired complications than non‐isolated patients?

What were the main findings?

There is no strong evidence that clinical deterioration and hospital‐acquired complications are more likely to occur to patients in isolation precautions for infection control.

This research is of relevance to acute care nurses.