bluuebunny/crossref_metadata_2025_split huggingface dataset:
Panorama of Gynecologic Cancer in Brazil
Authors: Paulino Eduardo , de Melo Andreia Cristina , Silva-Filho Agnaldo Lopes , Maciel Luiza de Freitas , Thuler Luiz Claudio Santos , Goss Paul , Nogueira-Rodrigues Angelica 
Published: October 2020

PURPOSE Little is known, or has been published previously, regarding consolidated data on the epidemiology of gynecologic cancers (GC) in Brazil. This article describes the incidence, morbidity, and mortality of women in Brazil affected with GC between the years of 2000 and 2017. METHODS Incidence, morbidity, and mortality data from patients with a diagnosis of one out of the five most common GC, cervical (CC), uterine (UC), ovarian (OC), vulvar (VvC), and vaginal (VgC), were obtained from three governmental sources of data. RESULTS From 2000 to 2015 CC, OC, and VgC incidence rates (IRs) decreased, whereas the IRs for UC and VvC remained relatively stable. Data from 382,932 women with GC were analyzed. Most patients presented with locally advanced or advanced disease at diagnosis: 60.1% of patients with CC, 31.2% of patients with UC, 67.2% of patients with OC, 45.2% of patients with VvC, and 67.0% of patients with VgC. Time from diagnosis to first treatment was ≥ 60 days in 58.0% of patients with CC, 58.5% of patients with UC, 27.0% of patients with OC, 55.3% of patients with VvC, and 52.7% of patients with VgC. Regarding mortality rates (MRs), with the exception of CC, UC, and VvC, which showed a slight decrease, MRs remained stable between 2000 and 2017. CONCLUSION A comparison with international data indicates that Brazilian patients are diagnosed with more advanced disease and face a longer delay between diagnosis and first treatment. Despite advances in screening and treatment, GC mortality has not decreased satisfactorily in this country.
Optimized Management of Nivolumab and Ipilimumab in Advanced Renal Cell Carcinoma: A Response-Based Phase II Study (OMNIVORE)
Authors: McKay Rana R. , McGregor Bradley A. , Xie Wanling , Braun David A. , Wei Xiao , Kyriakopoulos Christos E. , Zakharia Yousef , Maughan Benjamin L. , Rose Tracy L. , Stadler Walter M. , McDermott David F. , Harshman Lauren C. , Choueiri Toni K. 
Published: October 2020

PURPOSE In this phase II response-adaptive trial, we investigated the rational application of immune checkpoint blockade in renal cell carcinoma (RCC; ClinicalTrials.gov identifier: NCT03203473 ). METHODS We enrolled patients with metastatic RCC with no prior checkpoint inhibitor exposure. All patients received nivolumab alone with subsequent arm allocation based on response. Patients with a confirmed partial response (PR) or complete response (CR) within 6 months discontinued nivolumab and were observed (arm A). Patients with stable disease or progressive disease (PD) after no more than 6 months of nivolumab received two doses of ipilimumab (arm B). The primary endpoints were the proportion of patients with PR/CR at 1 year after nivolumab discontinuation (arm A) and proportion of nivolumab nonresponders who converted to PR/CR after ipilimumab (arm B). RESULTS Overall, 83 patients initiated treatment, of whom 96% had clear-cell histology, 51% were treatment naïve, and 67% had intermediate/poor-risk disease. Median follow-up was 19.5 months. Within 6 months, induction nivolumab resulted in a confirmed PR in 12% of patients (n = 10). Fourteen patients were not allocated to a study arm (seven because of toxicity, seven because of PD). Twelve patients (14%) were allocated to arm A and discontinued nivolumab, of whom five (42%; 90% CI, 18% to 68%) remained off nivolumab at ≥ 1 year. Of 57 patients (69%) allocated to arm B, two patients converted to a confirmed PR (4%; 90% CI, 1% to 11%), and no CRs were observed. CONCLUSION In this study, nivolumab followed by two doses of ipilimumab resulted in no CRs and a low PR/CR conversion. The number of patients evaluated for nivolumab discontinuation was too small to assess the value of this approach. Currently, our data do not support a response-adaptive strategy for checkpoint blockade in advanced RCC.
The Global Far North
Authors: Yeager Stephen 
Published: October 2020

AbstractThis essay describes a plan for Indigenizing medieval studies that has two elements. The first is an area of research inquiry, “The Global Far North, 500–1500 CE,” which moves past the written records of the Vinland sagas to privilege alternative forms of evidence about cultural contact in the defined period, particularly the oral traditional evidence of Indigenous communities. The project’s investigations will apply the emerging protocols for research ethics and for reciprocity with Indigenous communities, and they will aim to historicize and challenge settler notions of legality that rely on written documents. The essay concludes by arguing that teaching, service, and community outreach must be prioritized over publication as modes of professional activity more conducive to Indigenization’s political goals. Decolonizing medieval studies will require not only that we engage with Indigenous communities but also that we actively center their concerns and contributions at every step.
Mitochondria and the thermal limits of ectotherms
Authors: Chung Dillon J. , Schulte Patricia M. 
Published: October 2020

ABSTRACTTemperature is a critical abiotic factor shaping the distribution and abundance of species, but the mechanisms that underpin organismal thermal limits remain poorly understood. One possible mechanism underlying these limits is the failure of mitochondrial processes, as mitochondria play a crucial role in animals as the primary site of ATP production. Conventional measures of mitochondrial performance suggest that these organelles can function at temperatures much higher than those that limit whole-organism function, suggesting that they are unlikely to set organismal thermal limits. However, this conclusion is challenged by recent data connecting sequence variation in mitochondrial genes to whole-organism thermal tolerance. Here, we review the current state of knowledge of mitochondrial responses to thermal extremes and ask whether they are consistent with a role for mitochondrial function in shaping whole-organism thermal limits. The available data are fragmentary, but it is possible to draw some conclusions. There is little evidence that failure of maximal mitochondrial oxidative capacity as assessed in vitro sets thermal limits, but there is some evidence to suggest that temperature effects on ATP synthetic capacity may be important. Several studies suggest that loss of mitochondrial coupling is associated with the thermal limits for organismal growth, although this needs to be rigorously tested. Most studies have utilized isolated mitochondrial preparations to assess the effects of temperature on these organelles, and there remain many untapped opportunities to address these questions using preparations that retain more of their biological context to better connect these subcellular processes with whole-organism thermal limits.
Health- and skill-related physical fitness profile of Brazilian children and adolescents: a systematic review
Authors: Pedretti Augusto , Mello Júlio Brugnara , Gaya Anelise Reis , Pedretti Alessandro , Cezar Araujo Gaya Adroaldo 
Published: October 2020

Since 1994, the Projeto Esporte Brasil (PROESP-Br) battery tests has been used to evaluate health- and skill-related physical fitness among aged 6-17 Brazilian schoolchildren. The aim of this study was to delineate the Brazilian children and youth’s physical fitness profile from a systematic review over studies that used the PROESP-Br proposal. The search was carried at PubMed, ScienceDirect, Lilacs, SciELO and Google Scholar. Original studies published between 1994 and 2017 about physical fitness (health and/or motor performance) with schoolchildren (children and/or adolescents) that used the PROESP-Br battery test were included. A total of 13.582 participants were evaluated to health-related fitness and 276 to skill-related fitness from 18 included studies. The methodological quality was evaluated using the Newcastle-Ottawa quality assessment scale adapted version. The results show that 27-30% of youngsters are at health “risk zone” for Body Mass Index (BMI), 70% for cardiorespiratory fitness (CRF), 50% and 65% for flexibility (FLEX) and muscular strength (MST), respectively. The data concerning skill-related fitness were inconsistent. In summary, the results suggest that Brazilian children and adolescents have low cardiovascular health level (BMI/CRF), mainly regarding CRF, and low muscle health level (FLEX/MST). We emphasize that the lack of studies regarding skill-related fitness, make it impossible to describe the profile of the components of this construct.
Salience and Mutual Fund Investor Demand for Idiosyncratic Volatility
Authors: Clifford Christopher P. , Fulkerson Jon A. , Jame Russell , Jordan Bradford D. 
Published: October 2020

We find that mutual fund investors are more likely to both purchase and redeem funds with high idiosyncratic volatility (IV). Investors’ tendency to purchase high IV funds is largely driven by high IV funds having more extreme returns, which increases the salience of the fund. Including flexible controls for extreme past returns over multiple horizons decreases the effect of IV on new investment, and experimental evidence corroborates that increasing the salience of extreme returns increases investor demand for IV. Demand for IV is higher among retail investors and funds with otherwise lower salience. Collectively, the evidence suggests that extreme returns attract investor attention and contribute to investors’ risk seeking behavior when purchasing mutual funds. This paper was accepted by David Simchi-Levi, finance.
Optical fiber surface waveguide with Fabry–Perot cavity for sensing
Authors: Chen Qi , Wang D. N. , Feng Gao , Wang Q. H. , Niu Y. D. 
Published: October 2020

A parallel structured optical fiber Fabry–Perot interferometer sensor is proposed and demonstrated for refractive index and strain sensing with low temperature cross sensitivity. The device consists of two Fabry–Perot cavities fabricated by a femtosecond laser: one is inscribed in the fiber surface waveguide and used for sensing, and the other one is located in the fiber core for referencing. Part of the light propagating in the fiber core can be directed to the fiber surface waveguide via an

X

coupler. Because of the evanescent field, the light traveling along the fiber surface waveguide interacts with the surrounding medium and enables external refractive index sensing. The measurement sensitivity of the device is enhanced due to the Vernier effect associated with the parallel structured two Fabry–Perot interferometers. The sensitivities of

∼

843.3

n
m

/

R
I
U

and

∼

101.8

p
m

/

µ
ε

have been obtained for refractive index and strain, respectively, and the corresponding temperature cross sensitivities are

∼

9.6

×

10

−
6

R
I
U

/

∘

C

and

∼
7.956
×

10

−
2

µ
ε

/

∘

C

, respectively. The device is featured with high robustness, compact size, and large sensitivity.
SE PERDER PARA SE ENCONTRAR
Authors: Santana Samuel Antônio 
Published: October 2020

Valendo-me de conceitos próprios à prática dos Viewpoints e relacionando-os à criação dramatúrgica em campo expandido, durante um processo de desconstrução onde miro minha própria trajetória artística, rememoro os passos como pistas para desvendar esse processo trilhado de Desmontagem Cênica, buscando tornar visível o invisível, pra poder me perder e reencontrar, enquanto rascunho a cartografia de uma um processo criativo e de pesquisa em artes da cena.
Identificación de activos y ciber activos críticos en sistemas de transmisión de energía eléctrica
Authors: Carreño Perez Juan Carlos , Espinel Ortega Alvaro 
Published: October 2020

resumen
Objetivo: Presentar una propuesta para la identificación de activos y ciber activos críticos, facilitando a los agentes del sector conocer su planta tecnológica instalada, clasificar sus activos y ciber activos, para que posteriormente se valore el estado de vulnerabilidad cibernética y se tomen las acciones necesarias para mantener su sistema en un nivel operativamente seguro.
Metodología: Debido al avance de los sistemas de comunicaciones y tecnologías electrónicas, se ha promulgado durante los últimos 18 años la implementación de estos beneficios tecnológicos a los sistemas de potencia eléctrica abarcando toda la cadena productiva de energía eléctrica, es decir, generación, transmisión, distribución, comercialización e incluso en proyectos de generación distribuida, con el propósito de brindar confiabilidad, selectividad y controlar de manera centralizada la información y gestión de todas las variables eléctricas. En consecuencia, la investigación se construyó a partir de modelar el funcionamiento desde la perspectiva de ciberseguridad e identificando los servicios, arquitecturas y topologías de operación del sistema de transmisión de energía eléctrica.
Resultados:
Anteriormente en los sistemas eléctricos, las únicas fallas que podrían producir una pérdida del suministro de energía eran las ocasionadas por descargas atmosféricas, sobrecargas de los circuitos o fallas en los activos del sistema como conductores, transformadores, interruptores, bujes entre otros. Ahora, con la integración de redes de comunicación en los sistemas energéticos, a estos imprevistos se suman problemas de seguridad cibernética como lo son la seguridad e integridad de la información, así como el control de acceso para la manipulación de los dispositivos de maniobras del sistema eléctrico.

Con base en este nuevo aspecto que puede ocasionar fallas y daños en la infraestructura eléctrica, se necesita conocer detalladamente los activos que pueden ser afectados y que a su vez su intervención maliciosa pueda afectar el sistema de transmisión de energía eléctrica. Por tal razón, en este documento se presenta una propuesta para la identificación de activos y ciber activos críticos, facilitando a los agentes del sector conocer su planta tecnológica instalada, clasificar sus activos y ciber activos.
Conclusiones: En este trabajo presenta una propuesta para la identificación de activos y ciber activos críticos, facilitando a los agentes del sector conocer su planta tecnológica instalada, clasificar sus activos y ciber activos, para que posteriormente se valore el estado de vulnerabilidad cibernética y se tomen las acciones necesarias para mantener su sistema en un nivel operativamente seguro.
Tendencias actuales, retos y oportunidades de los procesos de aprendizaje universitario aplicados a las ciencias forestales
Authors: Valverde Juan Carlos , Romero-Zúñiga Mariela , Vargas-Fonseca Lupita 
Published: October 2020

En las últimas décadas la introducción de nuevas tecnologías, técnicas de aprendizaje y métodos de enseñanza ha incidido en la simplificación del entendimiento de conceptos. La facilidad para encontrar información mediante fuentes de internet, redes sociales y medios interactivos ha generado el reforzamiento en los sistemas de aprendizaje dinámicos, en especial a nivel universitario. En el presente trabajo se estableció como objetivo analizar las tendencias de aprendizaje puestas en marcha en la educación superior, así como los retos y potenciales cambios que se deben considerar en próximos años con el fin de mejorar el aprendizaje y el incremento de conocimiento en estudiantes universitarios de Ciencias Forestales. Mediante una revisión bibliográfica se tuvieron en cuenta teorías psicológicas conductistas y cognitivas; además, se analizaron las tendencias de tipos de aprendizaje, desde la alternativa tradicional (memorística) hasta otras más nuevas como la cooperativa, emocional y latente, que estimulan el desarrollo y el uso de habilidades blandas. Los resultados evidenciaron que actualmente las tendencias se mueven hacia aprendizajes teórico-prácticos en los cuales la parte emocional y experimental toma relevancia y mejora la interacción con la realidad social y el entorno cercano. Finalmente, se consideraron las perspectivas a largo plazo en las que la implementación de e-learning (combinación de redes sociales), programas, videos y equipos informáticos impulsen el empoderamiento del nuevo conocimiento.
A fusion of research-informed teaching and teaching-informed research: Designing a scalable online ecosystem for new partnerships in educational research
Authors: Connolly Cornelia , Hall Tony , Ryan Marie , McMahon Jennifer , McGann Marek , Egan Alison 
Published: October 2020

This paper examines the unbundling of research in the context of the Teachers’ Research Exchange (T-REX) platform, the national flagship Internet platform in Ireland for teachers to access, use and engage in research. This paper draws on two theoretical frameworks: Laurillard’s conversational framework and Salmon’s five-stage model. The first highlights the experimental, exploratory and creative aspects of developing an overall framework to structure the digital learning environment for teachers-as-researchers. The second explores the future of higher education and systems like T-REX in the era of digital transformation and the emerging context of Education 4.0. The original contribution is the integration of these frameworks in the creation of an open and shared learning platform so that schools and teachers can be supported to access, collaborate in and undertake research. In particular, the paper outlines signature features of the T-REX design and the way it has emerged over the last 5 years as an innovative platform to mediate the fusion of research and teaching in education. The paper highlights key issues and challenges in unbundling the traditional university, particularly in the context of educational research, but also the imperative of doing so, in the emerging era of Education 4.0.
Implications for practice or policy:

Supporting teachers’ research engagement is increasingly identified as a key priority in the improvement of educational standards and systems.
T-REX is of value to educationalists interested in a shared learning and open online teacher-research platform.
There should be a dialogic approach to the relationship between teaching and research, where each informs and enhances the other.
Legal Language in the Legislative Text (The Case Study of the Bill on Higher Education and Science)
Authors: Lizisowa Maria Teresa 
Published: October 2020

AbstractThe aim of the paper is to determine whether the text of the act is edited in such a way that legal clarity is possible under conditions of legal certainty and predictability of citizen behaviour when applying the act. The bill: law on higher education and science is written in legal language. The genre pattern of the text maintains a normative procedure which is mutual to all legal orders. The text is performative because it is an act of law making. It is also normative because it sets general legal norms. In this article, the author assumes that the basic legal concept is the legal relationship.
Referential Transparency of Motivated Public Authorities' Names in Translations
Authors: Iluk Łukasz 
Published: October 2020

Abstract
The paper focuses on adequacy and clarity of motivated public authorities' names in translation of constitutional acts. In order to assess the adequacy level of identification of the authorities' name references in the source legal system, a survey has been conducted. Its results allowed to conclude, that literal translation of authorities' names in incompatible systems can be referentially empty, even for persons with field knowledge. However, it can generally be assumed, that the sufficient identification is determined by an adequate level of knowledge about the given subject (entity) in the source legal system. It is functional translation that offers a significant simplification in the process of decoding the terms used to denote authorities' names.
Odwrót od wolnego handlu na przykładzie Partnerstwa Transpacyficznego
Authors: Gwiazda Adam 
Published: October 2020

W ostatnich paru latach do władzy doszły w niektórych państwach zachodnich partie prawicowe, które bardziej posługują się argumentami politycznymi i nie dostrzegają korzyści, jakie niesie ze sobą wolny handel. Przykładem może być Parnterstwo Transpacyficzne (TPP), które miało doprowadzić do przyśpieszenia handlu i wzmocnienia współpracy gospodarczej w regionie Azji i Pacyfiku. Partnerstwo to miało też być przeciwwagą dla ekspansji gospodarczej Chin w tym regionie. Stany Zjednoczone wspierały prawie 7-letni proces negocjacji i doprowadziły przy końcu 2015 roku do podpisania porozumienia o utworzeniu TPP. Do początku 2017 roku porozumienie to nie zostało jednak ratyfikowane przez parlamenty państw członkowskich, a w lutym 2017 roku prezydent Donald Trump wycofał USA z tego partnerstwa. Stworzyło to szansę dla Chin, które forsują swoją koncepcję Regionalnego Kompleksowego Partnerstwa Gospodarczego (RCEP) i osłabiło zaufanie do Stanów Zjednoczonych wśród wielu dotychczasowych sojuszników tego mocarstwa.
Relacjonowanie prezydenckiej kampanii wyborczej w 2015 roku przez „Wiadomości” TVP1: zrównoważone czy stronnicze?
Authors: Klepka Rafał 
Published: October 2020

We współczesnych demokracjach media pełnią kilka istotnych ról: informowanie wyborców o kandydatach i ich programach, tłumaczenie działań kandydatów i ich oponentów, kontrolowanie rządzących oraz mobilizację polityczną wyborców. Wiedza elektoratu o kandydatach biorących udział w wyborach, ocena ich kandydatur, a w konsekwencji także decyzja o głosowaniu na określonego kandydata, pozostają w określonym związku z tym, jaki obraz danego kandydata został wykreowany w mediach. Szczególną rolę odgrywa tu telewizja, gdyż 81% respondentów wskazało, że głównym źródłem informacji na temat polityki są dla nich telewizyjne programy informacyjne. Artykuł przedstawia wyniki badań analizy zawartości „Wiadomości” TVP1 przed wyborami prezydenckimi w 2015 roku w Polsce. Celem badań była ocena, czy kampania relacjonowana była w sposób zrównoważony czy stronniczy. Analizie poddano widoczność medialną oraz wydźwięk newsów w najchętniej oglądalnym telewizyjnym programie informacyjnym.
Mediacja jako sposób rozwiązywania sporów gospodarczych o charakterze transgranicznym na przykładzie Polski i Niemiec
Authors: Kopka Artur 
Published: October 2020

Celem niniejszego opracowania jest nakreślenie specyfiki gospodarczych sporów transgranicznych oraz zaprezentowanie mediacji jako metody ich rozwiązywania, alternatywnej wobec sądów powszechnych, dającej zwaśnionym stronom możliwość zarówno ich szybszego i mniej kosztownego zakończenia, jak i kontynuowania relacji gospodarczych oraz rozwijania dalszej współpracy pomiędzy przedsiębiorcami. W pierwszym kroku określone zostaną cechy konstytutywne mediacji oraz specyfika mediacji transgranicznej ze szczególnym uwzględnieniem aspektów interkulturowych. W tym kontekście przedstawione zostaną specyficzne kompetencje mediatora, niezbędne do skutecznego przeprowadzenia postępowania mediacyjnego w tego typu konfliktach oraz podstawy prawne zastosowania mediacji w odniesieniu do sporów pomiędzy podmiotami z Polski i Niemiec. Omówione zostaną zarówno regulacje prawa polskiego i niemieckiego dotyczące mediacji, jak i ramy i uwarunkowania instytucjonalno-prawne postępowania mediacyjnego w UE w zakresie sporów gospodarczych o charakterze transgranicznym. Ponadto analizie poddane zostaną dane empiryczne dotyczące zakresu upowszechnienia mediacji w obu krajach, stosunku polskich i niemieckich przedsiębiorców do mediacji jako metody rozwiązywania sporów gospodarczych pomiędzy podmiotami z obu krajów oraz trudności w jej zastosowaniu wynikające z różnic kulturowych.