bluuebunny/crossref_metadata_2025_split huggingface dataset:
ArhGAP15, a RacGAP, Acts as a Temporal Signaling Regulator of Mac-1 Affinity in Sterile Inflammation
Authors: Margraf Andreas , Cappenberg Anika , Vadillo Eduardo , Ludwig Nadine , Thomas Katharina , Körner Katharina , Zondler Lisa , Rossaint Jan , Germena Giulia , Hirsch Emilio , Zarbock Alexander 
Published: August 2020

Abstract
During inflammation, leukocyte recruitment has to be tightly controlled to prevent overwhelming leukocyte infiltration, activation, and, consequently, organ damage. A central regulator of leukocyte recruitment is Rac1. In this study, we analyzed the effects of the RacGAP ArhGAP15 on leukocyte recruitment. Using ArhGAP15-deficient mice, reduced neutrophil adhesion and transmigration in the TNF-α–inflamed cremaster muscle and a prolongation of chemokine-dependent leukocyte adhesion could be observed. In a murine model of sterile kidney injury, reduced neutrophil infiltration, and serum creatinine levels were apparent. Further in vitro and in vivo analyses revealed a defective intravascular crawling capacity, resulting from increased affinity of the β2-integrin Mac-1 after prolonged chemokine stimulation of neutrophils. LFA-1 activity regulation was not affected. Summarizing, ArhGAP15 specifically regulates Mac-1, but not LFA-1, and affects leukocyte recruitment by controlling postadhesion strengthening and intravascular crawling in a Mac-1–dependent manner. In conclusion, ArhGAP15 is involved in the time-dependent regulation of leukocyte postadhesion in sterile inflammation.
Simulating patient matching to clinical trials using a property rights blockchain
Authors: Bergeron Jay , Nguyen Anh , Alt Casey , Brewster Nicole , Quoc Cuong Le Quy , Krohn Thomas , Luong Vien , Nguyen Michael , Telenti Amalio , Wulff Jennifer , Moss-Pultz Sean 
Published: August 2020

Objective:
Biomedical data processing generally requires the secure stepwise transfer of sensitive personal information across multiple parties. Mediating such operations using distributed secure digital ledgers, i.e., blockchains, is investigated in this article.

Materials and Methods:
The bitmark property rights blockchain was used to simulate the process of assessing individuals for enrollment to specific clinical trials. In the scenario presented, a sponsor publishes a recruitment call for a clinical trial and patients signal their willingness to participate in the trial through blockchain transactions. The blockchain creates and maintains digital references of the medical data assets of prospective study participants as well as digital property certificates for assigning access rights to corresponding medical data assets. Trial matching services review the patient blockchain records and recommend study participants that are likely to meet the enrollment criteria of recruiting clinical trials. Digital certificates assign transient access rights to the data assets of the prospective study participants. These certificates are transferred to pertinent matching services and sponsors, allowing these organizations to examine the candidacy of each prospective study participant.

Results:
The trial matching simulation demonstrates that property rights blockchains can implement complicated multiparty interactions, such as those associated with medical data exchange, without supplemental peer-to-peer communications.

Conclusions:
Blockchain-based data marketplaces of the type described, when coupled with data-controlled virtual infrastructure environments (i.e., Medical Data Trusts), provide a viable model for managing the transfer, provenance, and processing of individual health information.
New Public Sphere dan Perkembangan Teknologi Media Sosial di Kawasan MENA (Middle East and North Africa): Studi Kasus Peranan Media InternasionalterhadapPembentukan Social Networking dalam Egyptian Revolution
Authors: Rahmanillah Ajeng Rizqi 
Published: August 2020

<p align="center"><strong> </strong></p><p align="center"><strong>ABSTRACT</strong></p><p align="center"><strong> </strong></p><p><em>Massive movement of the Egyptian people, called the Egyptian Revolution, is part of a wave of democratization of the Arab Spring in the Middle East and North Africa.The purpose of this essay is to provide information about the influence of new public sphere and media technology, to the civil society movement in the region. The public sphere is the space of communication of ideas and projects that emerge from society and are addressed to the decision makers in the institutions of society. The global civil society is the organized expression of the values and interests of society. The relationships between government and civil society and their interaction via the public sphere define the polity of society. This essay is a qualitative study using the case study method. The results of this study showed that the development of global communication media has a significant influence on the civil society to develop their skills in using information technology. This has led to the Arab Spring in Tunisia became a successful spark that triggered the revolution in Egypt. Phase emergence of Reformers in the Arab Spring wave of democratization in Egypt indicate that the movement of the Reformers strongly associated with one of the instruments of mass communication become public means of expression, to spread the idea, and eventually forms a networking in a short time</em>.</p><p> </p><p><strong><em>Keywords: New Public Sphere, social media, social movement, egyption revolution</em></strong></p>
EVALUASI IMPLEMENTASI MANAJEMEN PENGETAHUAN DI KATOR PELAYAHAN PAJAK PRATAMA JAKARTA
Authors: Sumardi Rebin , Suharyono Suharyono , Elwisam Elwisam , Aldrianto Hendi 
Published: August 2020

<p><em>Knowledge management provides an opportunity for changes and information values and libraries to make themselves relevant to the times. The purpose of this study is to determine the extent of the application of knowledge management at the Pratama Tamansari Dua Jakarta Tax Office. The method in this study is simple qualitative through the technique of observing objects in the field and literature. Based on the results of the research and evaluation it turned out that the Tamansari Dua Tax Service Office had implemented Knowledge Management well and consistently so that the process of achieving goals had a basis for reference in work and had shown significant results in trying to achieve individual and organizational performance. Institutional innovation and development is faster because with the knowledge management cycle pattern all knowledge is well archived and can be easily accessed by all members. However, the willingness of each individual in the member's institution to be explicit in all tacit knowledge is needed so that it can be disseminated to other members.</em></p><p> </p><p>Keywords<em>: Evaluation, Implementation, Knowledge Management</em></p>
AN ANNOTATED TRANSLATION OF A NOVEL ENTITLED THE GREAT PATRIOTIC WAR OF THE SOVIET UNION
Authors: Adnyana I Nyoman 
Published: August 2020

<p>This research is about annotated translation with the object a novel entitled <em>The Great Patriotic War of the Soviet Union</em> written by Joseph Stalin. The problems of this research are: (1) What are the difficulties encountered by the researcher in translating the source text? and (2) How are those difficulties solved in the translation? The aims of this research are: (1) To identify the difficulties encountered by the translator in translating the source text; and (2) How the difficulties are solved which include strategies in translating the source text. In conducting this annotated translation, the researcher employed introspective and retrospective methods. The researcher analyzed 25 annotations of problems out of 100 items of data related to lexicon, grammatical structure, communication situation, and cultural context, and revealed that there were 17 lexicons, 7 grammatical structures, 1 communication situation. Those difficulties which, at the same time, had become problems were analysed to attain solutions in accordance with the relevant translation strategies and translation theories, namely: descriptive translation, naturalization, paraphrasing, addition, deletion, cultural equivalent. The finding of this research can be concluded that translation theories are still needed or even they are very important in the process of translation to produce a good translation. Appropriate translation theories, methods, and procedures can overcome translation problems.</p><p>Key words: annotation, lexicon, grammatical structure, communication situation, and cultural context.</p>
MEMAHAMI KOMPLEKSITAS GROWTH TRIANGLES
Authors: Nizmi Yusnarida Eka 
Published: August 2020

<p><em>Tulisan ini menganalisa beberapa konseptual utama dalam lingkup fenomena growth triangle yang dibagi menjadi beberapa pembahasan. Diawali dengan etimologi dari growth triangle dan membahas apa yang membedakannya dengan bentuk kerjasama ekonomi regional lainnya. Terminologi Growth Triangles muncul setelah deputi Pedana Menteri Singapura Goh Chok Tong menggunakannya pada Desember 1989 untuk menjabarkan kerjasama ekonomi subregional yang melibatkan Singapura, Selatan Johor dan Pulau Batam di Indonesia. Growth Triangles, mengeksploitasi komplementaritas diantara negara-negara yang berbeda secara geografis untuk mendapatkan keuntungan kompetitif dalam rangka promosi ekspor. Growth Triangles menampilkan karakteristik-karakteristik mikrolinkages, namun dibedakan oleh komposisi tripartite. Mereka dianggap sebagai “transnational economic” dimana ekonomi-ekonomi yang memiliki perbedaan sumber daya dari ragam faktor produksi, jasa, tenaga kerja, modal, sumber daya alam, efesiensi-efesiensi yang ada, dan kekuatan-kekuatan masing-masing negara. Dalam teori, lebih besar comaprative advantage yang ada, maka dapat menjamin anggota-anggota yang ada untuk bekerja secara bersama-sama diluar batas-batas negara mereka. Growth Triangle merujuk pada dimensi Comparative tersebut. Area-area ekonomi pinggiran, yang jauh dari pusat-pusat utama, secara khusus diuntungkan. Dalam Growth Triangle juga ditemukan insentif sosial-ekonomi yang meningkat yakni peluang-peluang mendapatkan pendapatan dan pekerjaan.</em></p><p><em> </em></p><p><em> </em><strong><em>Kata Kunci: Kerjasama ekonomi, Growth Triangle, Prospek dan Pertumbuhan, Comparative Advantage, Keuntungan Kompetitif.</em></strong></p>
Crecimiento y metabolitos secundarios de Stevia pilosa Lag. en tres condiciones edafoclimáticas en el estado de Hidalgo, México
Authors: Romero-Figueroa José C. , Rodríguez-Mendoza María de las Nieves , Gutiérrez-Castorena Ma. del Carmen , Escalante-Estrada José Alberto Salvador , Peña-Valdivia Cecilia Beatriz , Cueto-Wong José Antonio 
Published: August 2020

Introducción: La distribución de Stevia pilosa Lag. y su contenido de metabolitos con propiedades terapéuticas se han documentado; sin embargo, no hay reportes del desarrollo in situ y de los factores que influyen en el crecimiento de la planta.Objetivo: Cuantificar el crecimiento, contenido fitoquímico y nutrimental de plantas de S. pilosa in situ bajo tres condiciones edafoclimáticas del estado de Hidalgo, México.Materiales y métodos: En los sitios denominados Huasca de Ocampo (HO), Mineral del Chico (MCh) y Mineral del Monte (MM), con clima, suelo y altitud diferentes, se colectó suelo y se hicieron tres muestreos de plantas para dar seguimiento al desarrollo de la especie. En el último muestreo se cuantificó la concentración nutrimental y fitoquímica.Resultados y discusión: La cantidad de plantas varió en función de los sitios de muestreo, siendo mayor en MCh (12 plantas·m-2). La tasa de crecimiento y el área foliar se relacionaron directamente. En plantas de MCh y MM, la fotosíntesis neta solo abasteció la demanda en los dos primeros muestreos, donde hubo acumulación significativa (P ≤ 0.05) de materia, mientras que en HO abasteció todos los muestreos. Las plantas de MCh y HO tuvieron mayor concentración nutrimental (P ≤ 0.05). Las plantas de MCh y MM presentaron mayor concentración de fenoles y flavonoides, y las de HO sobresalieron en terpenos totales.Conclusiones: Las condiciones edafoclimáticas en los tres sitios del estado de Hidalgo modificaron la presencia, forma de crecimiento y desarrollo de S. pilosa.
Análisis regional de los factores del cambio de cobertura del bosque de encino (Quercus sp.) en la región Tehuacán-Cuicatlán, México
Authors: Osorio-Olvera Laura Paulina , García-Romero Arturo , Couturier Stéphane André , Guerra-Martínez Francisco 
Published: August 2020

Introducción: Los bosques de encino (Quercus sp.) están representados escasamente en las Áreas Naturales Protegidas de México y son sumamente vulnerables a la deforestación.Objetivo: Evaluar la dinámica regional de la deforestación y la recuperación, así como los factores del cambio de cobertura y uso del suelo (CCUS) en el bosque de encino de la Región Tehuacán-Cuicatlán (RTC) que incluye el polígono de la Reserva de la Biosfera Tehuacán-Cuicatlán (RBTC) y su zona de influencia.Materiales y métodos: La dinámica de CCUS se analizó en dos periodos; uno previo a la declaración de la RBTC (1979-2001) y otro posterior (2001-2011). El análisis de los factores consistió en dos etapas: análisis de regresión logística a partir de la interpolación espacial de los factores, y análisis de las tendencias socioeconómicas municipales a partir de las tasas de cambio.Resultados y discusión: El bosque de encino se deforestó previo al decreto de la RBTC, con una tasa anual de cambio de -0.97 %. La deforestación estuvo asociada a áreas de baja pendiente, cercanas a localidades y con presencia de mayor población masculina. En contraste, en el periodo posterior resaltó su recuperación (0.22 %), la cual estuvo asociada con áreas de pendiente y altitud elevadas, y disminución de la población masculina.Conclusión: El decreto de la RBTC no debe considerarse la causa principal del cambio en los procesos de CCUS; sin embargo, debe aceptarse una injerencia indirecta.
Análisis del ambiente físico del trabajo en aserraderos de El Salto, Durango, México
Authors: Silva-Lugo Edwin D. , Aragón-Vásquez Alondra Y. , Nájera-Luna Juan A. , Hernández Francisco J. , De la Cruz-Carrera Ricardo , Medina-Urrutia Víctor Manuel 
Published: August 2020

Introducción: En los aserraderos, los trabajadores desempeñan su labor en un medio físico adverso que influye en el bienestar, desconociendo si los niveles de seguridad en el área son aceptables. Objetivo: Analizar la exposición de los trabajadores al ruido, confort térmico e iluminación en cinco puestos de trabajo de seis aserraderos de la región de El Salto, Durango, México. Materiales y métodos: Las variables físicas del ambiente de trabajo se midieron directamente en tres horarios del día durante siete días laborales en cinco puestos de trabajo (montacargas, desorilladora, trocero, reaserradora y sierra principal). El tiempo máximo permisible de exposición al ruido, el confort térmico mediante la temperatura efectiva y la iluminación del área de trabajo se determinaron. Las diferencias estadísticas de las variables físicas entre puestos de trabajo, aserraderos y horarios del día se detectaron mediante análisis de varianza y pruebas de comparación de rangos de la mediana de Kruskal-Wallis. Resultados y discusión: El nivel de ruido (85 a 102 dB[A]) representa mayor riesgo auditivo en los puestos de la sierra principal, la reaserradora y el trocero al rebasar los 90 dB(A). El confort térmico fue de 20 °C, el cual garantiza que el trabajador puede estar expuesto el 100 % del tiempo de la jornada laboral a dicha temperatura. Los niveles de iluminación resultaron altos al superar los 2 000 lx. Conclusiones: Los niveles de ruido e iluminación son altos en los aserraderos evaluados y representan un riesgo para la seguridad de los trabajadores si no se vigila el uso obligatorio de protectores auriculares y oculares.
Sistemas de ecuaciones de altura-diámetro-edad para Pinus arizonica Engelmann y Pinus durangensis Martínez en rodales mezclados de Durango, México
Authors: Quiñonez-Barraza Gerónimo , Zhao Dehai , De los Santos-Posadas Héctor M. 
Published: August 2020

Introducción: La altura total (H) y el diámetro normal (DBH) son variables importantes en el inventario forestal y son la base de sistemas de crecimiento y rendimiento.Objetivo: Generar tres sistemas de ecuaciones de predicción y proyección para Pinus arizonica Engelmann (Pa) y Pinus durangensis Martínez (Pd) en rodales mezclados de Durango, México.Materiales y métodos: Ecuaciones de DBH con corteza como funciones del DBH sin corteza se desarrollaron y la relación H-DBH fue extendida a tres relaciones con el uso de la edad (A): H-DBH, H-A y DBH-A. Los sistemas de ecuaciones de H-DBH-A se desarrollaron a partir de una base de datos de 46 y 66 árboles de análisis troncales con 601 y 760 mediciones longitudinales de Pa y Pd, respectivamente. Los ajustes se realizaron con regresión aparentemente no relacionada y con el enfoque de variables Dummy con parámetros comunes y específicos.Resultados y discusión: Las relaciones mostraron precisión significativa en los estadísticos de ajuste evaluados (coeficiente de determinación ajustado, raíz del cuadrado medio del error, criterio de información de Akaike, error estándar de la estimación y sesgo). Las ecuaciones inversas de las tres relaciones conformaron un sistema global de ecuaciones de predicción y proyección.Conclusiones: Las ecuaciones son útiles para predecir y proyectar H y DBH y pueden usarse como variables de entrada en modelos de crecimiento y rendimiento.
Observation of wave-driven air–water turbulent momentum exchange in a large but fetch-limited shallow lake
Authors: Lükő Gabriella , Torma Péter , Krámer Tamás , Weidinger Tamás , Vecenaj Zeljko , Grisogono Branko 
Published: August 2020

Abstract. Wind-induced waves play a key role in air–sea momentum and heat exchange. Fetch-limited shallow lakes differ significantly from open ocean circumstances since the wave field is characterized by young and growing waves that (i) are steeper and can collapse by white-capping at lower wind speeds, and (ii) travel with lower phase velocity. Consequently, momentum (and heat) flux estimation methods arising from oceanographic observations cannot be directly applied; however, few attempts have been made to describe air–water turbulent exchange in case of large, but still fetch-limited shallow lakes. Within a Croatian-Hungarian measurement campaign, turbulent flux measurements were performed in Lake Balaton.
Momentum and heat fluxes were measured with eddy-covariance technique at an
offshore station, while waves were simultaneously recorded with underwater
acoustic surface tracking. Momentum fluxes were also recorded at two further stations closer to the shore. In this study, we analyze the measured wind stress and surface waves to reveal surface drag in case of highly fetch-limited conditions. We compare our results with relevant model
formulations that attempt to estimate momentum flux using different wave
state parameterizations (i.e. wave age and wave slope modified Charnock
formulations) and show that derived drag and roughness length parameterizations differ significantly from oceanographic formulas.
Climatic information archived in ice cores: impact of intermittency and diffusion on the recorded isotopic signal in Antarctica
Authors: Casado Mathieu , Münch Thomas , Laepple Thomas 
Published: August 2020

Abstract. The isotopic signal (δ18O and δD) imprinted in ice cores from Antarctica is not solely generated by the temperature sensitivity of the isotopic composition of precipitation, but it also contains the signature of the intermittency of the precipitation patterns, as well as of post-deposition processes occurring at the surface and in the firn. This leads to a proxy signal recorded by the ice cores that may not be representative of the local climate variations. Due to precipitation intermittency, the ice cores only record brief snapshots of the climatic conditions, resulting in aliasing of the climatic signal and thus a large amount of noise which reduces the minimum temporal resolution at which a meaningful signal can be retrieved. The analyses are further complicated by isotopic diffusion, which acts as a low-pass filter that dampens any high-frequency changes. Here, we use reanalysis data (ERA-Interim) combined with satellite products of accumulation to evaluate the spatial distribution of the numerical estimates of the transfer function that describes the formation of the isotopic signal across Antarctica. As a result, the minimum timescales at which the signal-to-noise ratio exceeds unity range from less than 1 year at the coast to about 1000 years further inland. Based on solely physical processes, we are thus able to define a lower bound for the timescales at which climate variability can be reconstructed from the isotopic composition in ice cores.
Aeroelastic load validation in wake conditions using nacelle-mounted lidar measurements
Authors: Conti Davide , Dimitrov Nikolay , Peña Alfredo 
Published: August 2020

Abstract. We propose a method for carrying out wind turbine load validation in wake conditions using measurements from forward-looking nacelle lidars. Two lidars, a pulsed- and a continuous-wave system, were installed on the nacelle of a 2.3 MW wind turbine operating in free-, partial-, and full-wake conditions. The turbine is placed within a straight row of turbines with a spacing of 5.2 rotor diameters, and wake disturbances are present for two opposite wind direction sectors. The wake flow fields are described by lidar-estimated wind field characteristics, which are commonly used as inputs for load simulations, without employing wake deficit models. These include mean wind speed, turbulence intensity, vertical and horizontal shear, yaw error, and turbulence-spectra parameters. We assess the uncertainty of lidar-based load predictions against wind turbine on-board sensors in wake conditions and compare it with the uncertainty of lidar-based load predictions against sensor data in free wind. Compared to the free-wind case, the simulations in wake conditions lead to increased relative errors (4 %–11 %). It is demonstrated that the mean wind speed, turbulence intensity, and turbulence length scale have a significant impact on the predictions. Finally, the experiences from this study indicate that characterizing turbulence inside the wake as well as defining a wind deficit model are the most challenging aspects of lidar-based load validation in wake conditions.
The Impact of E-Learning Strategy on Students' Academic Achievement. Case Study: Al- Quds Open University.
Authors: Abdel Jawad Yousef Abdel Latif , Shalash Basem 
Published: August 2020

The study examines the effect of e-learning on the students’ academic performance at Al-Quds Open University. 382 students have been randomly selected from the university's official records where a statistical analysis of the study variables was performed using the Statistical Package of Social Sciences program (SPSS.20). The study hypotheses were tested by Paired Samples T-tests.The study has revealed that there are statistically significant differences in the students’ academic performance over the implementation of the e-learning strategy with regard to the level of the vast majority of students, gender, educational program, as well as their academic level.The study recommends the necessity of enhancing the e-learning strategy in the higher education institutions to foster the students’ academic performance taking into account the specificity of some learning programs such as the Arabic language programs and the social studies.