bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Telehealth in Fellowship-Affiliated Developmental Behavioral Pediatric Practices During the COVID-19 Pandemic
Authors: Wallis Kate E. , Mulé Christina , Mittal Shruti , Cerda Natalie , Shaffer Rebecca , Scott Angela , Langkamp Diane , Augustyn Marilyn , Perrin Ellen , Soares Neelkamal , Blum Nathan J. 
Published: December 2020

ABSTRACT:

Objective:
This study aims to describe the use of telehealth in developmental behavioral pediatric (DBP) fellowship-affiliated practices during the coronavirus disease 2019 (COVID-19) global pandemic.

Methods:
An electronic survey was disseminated to all DBP fellowship-associated practice locations to determine the use of telehealth in DBP care provision, before and since the beginning of the COVID-19 pandemic. We analyzed responses using descriptive statistics.

Results:
A total of 35 of 42 eligible practice sites responded (83% response rate). Most sites (51.4%) reported using telehealth less than once per month before the COVID-19 pandemic. Since the onset of COVID-19, 100% of programs reported conducting video-based telehealth visits multiple days per week. Most sites reported conducting evaluations and follow-up visits for attention-deficit/hyperactivity disorder, autism spectrum disorder, behavioral concerns, developmental delay, genetic disorders, and learning disability. Most sites were able to continue medication management by telehealth (>88%), offer interpreter services for families with limited English proficiency participating in telehealth visits (>90%), and incorporate trainees and interdisciplinary team members in telehealth visits (>90%). Greater variability was observed in sites' ability to collect telehealth practice evaluation measures.

Conclusion:
Most sites are providing evaluations and ongoing care for DBP conditions through telehealth. The rapid adoption of telehealth can have ramifications for the way that DBP care is delivered in the future; therefore, it is imperative to understand current practice patterns and variations to determine the best use of telehealth.
The formation and implications of giant blocks and fluid escape structures in submarine lateral spreads
Authors: Wu Nan , Jackson Christopher A.‐L. , Johnson Howard D. , Hodgson David M. , Clare Michael A. , Nugraha Harya D. , Li Wei 
Published: December 2020

AbstractLateral spread and submarine creep are processes that occur near the headwalls of both terrestrial landslides and submarine mass‐transport complexes (MTCs). Both submarine creep and spread deposits may contain giant (km‐scale) coherent blocks, but their transport processes remain poorly constrained. Here we use seismic reflection data to determine the geometry, scale, and origin of a Late Miocene mass‐transport complex (MTC) located in the Kangaroo Syncline, offshore NW Australia. We show that this large remobilised mass of carbonate ooze is ca. 170–300 m thick and covers an area of at least 1,050 km2. The deposit is defined internally by two distinct seismic facies: (a) large, upward‐tapering blocks (210–300 m thick, 170–210 m wide and 800–1,200 m long) with negligible internal deformation, which decrease in height and spacing along the transport direction (identical, but in situ, seismic facies forms undeformed slope material immediately updip of the deposit headwall); and (b) troughs (160–260 m thick, 190–230 m wide and 800–1,200 m long) comprising moderately deformed strata, which contain ‘v’‐shaped, pipe‐like structures that extend upwards from the inferred basal shear surface to the top surface. The lack of deformation within the blocks, and their correlation to adjacent in situ deposits, suggests they underwent limited transport (ca. 50 m–70 m). The relatively high degree of deformation within the intervening troughs is attributed to the vertical expulsion of fluids and sediment during hydraulic failure of the sediment mass. We present a hydraulic failure model that invokes evacuation of the lower slope by a precursor MTC and which formed the space to trigger the lateral spread. Our study also provides new insights into the genesis and rheology of subaqueous lateral spreads. The genetic links identified between mass wasting and spatially focused fluid flow, as well as disturbing the deep seafloor, indicate that submarine landslides may also create important deep‐sea biodiversity hotspots.
High frequency of anticoagulation management errors preceding ischaemic strokes in atrial fibrillation
Authors: Wong Edmond , Aaqib Muhammad , Thijs Vincent 
Published: December 2020

AbstractBackgroundAnticoagulants are recommended to prevent cardioembolic stroke in most patients with atrial fibrillation (AF). Management errors with anticoagulation and use of aspirin instead of anticoagulants have been documented worldwide, especially with vitamin K antagonists.AimsTo assess the rate of anticoagulant mismanagement errors in patients admitted with ischaemic stroke and the clinical correlates with stroke outcomes in the era of non‐vitamin K oral anticoagulants.MethodsWe performed a retrospective analysis of patients admitted with ischaemic stroke and history of AF to a single‐centre tertiary hospital stroke unit in Melbourne, Australia, between January 2016 and June 2019. We assessed management errors as defined using European Heart Rhythm Association criteria with anticoagulation in the 2 weeks prior to the index stroke.ResultsA total of 306 patients with AF and ischaemic stroke was included, of whom 196 (64%) had management errors. Patients with management errors were older (median age 84 vs 81 years; P = 0.002) and more often female (53% vs 38%; P = 0.02). Of those with management errors, 74 (37%) were not prescribed any anticoagulation despite increased stroke risk and absence of contraindications and 40 (20%) had anticoagulation inappropriately ceased. Mortality at 3 months was 32% in those with management errors, compared with 17% in the appropriately anticoagulated group (P = 0.005).ConclusionsInappropriate management of anticoagulants is present in the majority of acute ischaemic stroke in the 2 weeks preceding the event and is linked to higher mortality. Improved anticoagulation practice has the potential to substantially reduce stroke rates in patients with AF.
The endocannabinoid system – current implications for drug development
Authors: Fowler C. J. 
Published: December 2020

AbstractIn this review, the state of the art for compounds affecting the endocannabinoid (eCB) system is described with a focus on the treatment of pain. Amongst directly acting CB receptor ligands, clinical experience with ∆9‐tetrahydracannabinol and medical cannabis in chronic non‐cancer pain indicates that there are differences between the benefits perceived by patients and the at best modest effect seen in meta‐analyses of randomized controlled trials. The reason for this difference is not known but may involve differences in the type of patients that are recruited, the study conditions that are chosen and the degree to which biases such as reporting bias are operative. Other directly acting CB receptor ligands such as biased agonists and allosteric receptor modulators have not yet reached the clinic. Amongst indirectly acting compounds targeting the enzymes responsible for the synthesis and catabolism of the eCBs anandamide and 2‐arachidonoylglycerol, fatty acid amide hydrolase (FAAH) inhibitors have been investigated clinically but were per se not useful for the treatment of pain, although they may be useful for the treatment of post‐traumatic stress disorder and cannabis use disorder. Dual‐acting compounds targeting this enzyme and other targets such as cyclooxygenase‐2 or transient potential vanilloid receptor 1 may be a way forward for the treatment of pain.
Semiparametric analysis of interval‐censored failure time data with outcome‐dependent observation schemes
Authors: Zhu Yayuan , Chen Ziqi , Lawless Jerald F. 
Published: December 2020

AbstractDisease progression is often monitored by intermittent follow‐up “visits” in longitudinal cohort studies, resulting in interval‐censored failure time outcomes. Furthermore, the timing and frequency of visits is often found related to a person's history of disease‐related variables in practice. This article develops a semiparametric estimation approach using weighted binomial regression and a kernel smoother to analyze interval‐censored failure time data. Visit times are allowed to be subject‐specific and outcome‐dependent. We consider a collection of widely used semiparametric regression models, including additive hazards and linear transformation models. For additive hazards models, the nonparametric component has a closed‐form estimator and the estimators of regression coefficients are shown to be asymptotically multivariate normal with sandwich‐type covariance matrices. Simulations are conducted to examine the finite sample performance of the proposed estimators. A data set from the Toronto Psoriatic Arthritis (PsA) Cohort Study is used to illustrate the proposed methodology.
Compliant Mechanisms That Use Static Balancing to Achieve Dramatically Different States of Stiffness
Authors: Kuppens P. R. , Bessa M. A. , Herder J. L. , Hopkins J. B. 
Published: December 2020

Abstract
Stiffness in compliant mechanisms can be dramatically altered and even eliminated entirely by using static balancing. This requires elastic energy to be inserted before operation, which is most often done with an additional device or preloading assembly. Adding such devices contrasts starkly with primary motivations for using compliant mechanisms, such as part count reduction, increased precision, and miniaturization. However, statically balanced compliant mechanisms with a fully monolithic architecture are scarce. In this article, we introduce two novel statically balanced compliant mechanisms with linear and rotary kinematics that do not require preloading assembly, enabling miniaturization. Static balance is achieved by the principle of opposing constant force and extended to a rotational device by using opposing constant torque mechanisms for the first time. A constant force mechanism based on existing work is used and inspired a novel constant torque mechanism. A single-piece device is obtained by monolithically integrating a bistable switch for preloading, which allows static balance to be turned on and off. The linear device reduces stiffness by 98.5% over 10 mm, has significantly reduced device complexity and has doubled relative range of motion from 3.3% to 6.6% compared to the state of the art. The rotary device reduces stiffness by 90.5% over 0.35 rad.
Application Research of Precision Medical Model Based on Big Data in Primary Health Care in China
Authors: Yin Tianlu 
Published: December 2020

Abstract
In this paper, relevant literatures on precision medicine and primary health care under big data from 2005 to 2020 were selected on CNKI, Wanfang Data Knowledge Service Platform, PUBMED and so on. A total of 98 literatures were included to summarize the development, difficulties and suggestions on precision medicine in China. This paper analyzes the application of precision medicine in China’s primary health care and the technical and social problems that precision medicine faces in the era of big data, and puts forward the next research direction of community precision medicine prevention and treatment. Conclusion,: the application of precision medicine in primary health care is still in its infancy. Genomic data, sample management, data quality control standards and data management platform construction are the foundation of community precision medicine. “Intelligent precision medicine” will be the future development direction.
Inflammatory patterns in plasma associate with hepatocellular carcinoma development in cured hepatitis C cirrhotic patients
Authors: Owusu Sekyere Solomon , Port Kerstin , Deterding Katja , Cornberg Markus , Wedemeyer Heiner 
Published: December 2020

AbstractIntroductionThe risk of hepatocellular carcinoma persists in some patients despite achieving sustained virologic response with current interferon‐free direct‐acting antiviral therapy for hepatitis C. The subject of an even higher carcinoma risk in this context has been reported and is currently being debated. The quest for understanding this paradox relative to the dynamics of inflammatory biomarkers in cirrhosis patients receiving antiviral therapy thus remains a subject of importance.ObjectiveHere, we aimed at evaluating the effects of direct‐acting antiviral therapy‐induced hepatitis C cure on plasmatic markers of systemic inflammation measured before, during and after treatment. Specifically, soluble immune mediator phenotype associations that impact the odds of hepatocellular carcinoma development and the related changes that arise upon direct‐acting antiviral‐mediated hepatitis C clearance in cirrhosis patients was investigated.MethodsEmploying multiplex technology that measured up to 91 circulating biomarker proteins, we profiled the plasma soluble immune mediator concentrations of cirrhosis patients who developed posttreatment hepatocellular carcinoma and their respective negative controls, before and after direct‐acting antiviral treatment.ResultsElevated pretherapy concentrations of specific soluble immune mediators including MCP‐3, GDNF, CDCP1, IL‐17C, IL‐17A, signalling lymphocytic activation family 1, CCL11, FGF‐5, LIF‐R, interleukin 10 (IL‐10), IL‐10RA, IL‐15RA, beta NGF, CCL28, CCL25 and NT‐3 distinguished patients who developed posttreatment hepatocellular carcinoma relative to those that did not. Particularly, GDNF, FGF‐5 and IL‐15RA displayed independent predictive biomarker attributes for delineating carcinoma emergence regardless of de novo or recurrence groupings. Upon successful therapy, the elevated pretherapy soluble immune mediator establishment of the patients who eventually developed hepatocellular carcinoma stayed largely unperturbed whereas a panel of some 38 soluble immune mediators in the posttherapy carcinoma‐free patients experienced significant ameliorations.ConclusionsThese results have considerable implications for delineating potential hepatocellular carcinoma emergence before initiating direct‐acting antiviral therapy for hepatitis C in cirrhosis patients. They provide preliminary contribution to unravelling cases where the benefit of direct‐acting antiviral therapies would be superior to the risk of developing carcinoma.
Information and Communication Technology Adoption and the Demand for Female Labor: The Case of Indian Industry
Authors: Jain Ritika 
Published: December 2020

Abstract
Does the adoption of information and communication technologies (ICTs) lead to better and more inclusive women representation in the workforce? We explore this question for India- a developing economy characterized by strong patriarchal norms and gender-based discrimination in the workforce. Using the World Bank Enterprise Survey of 2014, we examine the effect of computerization, email usage and Internet services on three aspects of female representation- total female representation, representation across the hierarchy of workforce and quality of female representation. Using instrumental variable estimation models, we find that ICT adoption has a positive effect on the total share of women in the workforce. A deeper analysis reveals that the positive effect of ICTs on female employment is limited to the share of females in the highly skilled workforce. In contrast, it does not affect the female share in the low or unskilled workforce. This indicates that ICT adoption has a semi-polarization effect on women. We also find that ICT adoption is associated with better quality females in the workforce. Both rises in demand for skilled people and a women-friendly work environment drive these results. The overall findings establish the effective role of ICTs in enhancing women’s representation in the workforce.
miR-339-3p regulated acute pancreatitis induced by caerulein through targeting TNF receptor-associated factor 3 in AR42J cells
Authors: Wang Qi , Liu Shaofeng , Han Zhen 
Published: December 2020

AbstractAcute pancreatitis (AP) is an inflammatory disease with high morbidity and mortality. The regulation mechanism of miRNA is involved in the production and development of various diseases, but the regulation mechanism of miRNA in AP is still not fully elucidated. The expression of miR-339-3p was detected using quantitative real-time PCR. The levels of TNF-α, IL-1β, and IL-6 were detected using enzyme-linked immunosorbent assay. Cell apoptosis was measured using flow cytometry. The protein expressions of TNF receptor-associated factor 3 (TRAF3), Bcl-2, C-caspase 3, Bax, p-p38, and p38 were measured using western blot. Luciferase reporter assay and RNA immunoprecipitation assay were applied to ensure that miR-399-3p targeted TRAF3. Caerulein promoted the expression of TNF-α, IL-1β, and IL-6, enhanced the expression of C-caspase 3 and Bax while inhibited Bcl-2 protein expression. Meanwhile, caerulein also reduced the expression of miR-339-3p and induced the expression of TRAF3 in rat pancreatic acinar cells. miR-399-3p transfection inhibited the levels of TNF-α, IL-1β, and IL-6 and C-caspase 3 and Bax protein expression as well as suppressed cell apoptosis, while increased Bcl-2 protein expression in caerulein-induced AP. TRAF3 has been verified as a target of miR-339-3p. Interestingly, the reduction of miR-399-3p inhibited the p38 pathway, which was impaired by the upregulation of TRAF3. In addition, the suppression effects of miR-339-3p on cell inflammation and apoptosis in caerulein-induced AP were reversed by enhancing TRAF3 expression. In this study,in vitromodel of AP was characterized by strong inflammation and cell apoptosis. We have first demonstrated the regulatory network of miR-339-3p and TRAF3. Overexpression of miR-339-3p inhibited cell inflammation and cell apoptosis in caerulein-induced AP through modulating TRAF3 expression via the p38 pathway, providing a new therapeutic target in the treatment of AP.
Optimization of sliding mode control with PID surface for robot manipulator by Evolutionary Algorithms
Authors: Loucif Fatiha , Kechida Sihem 
Published: December 2020

AbstractIn this paper, a sliding mode controller (SMC) with PID surface is designed for the trajectory tracking control of a robot manipulator using different optimization algorithms such as, Antlion Optimization Algorithm (ALO) Sine Cosine Algorithm (SCA) Grey Wolf Optimizer (GWO) and Whale Optimizer Algorithm (WOA). The aim of this work is to introduce a novel SMC-PID-ALO to control nonlinear systems, especially the position of two of the joints of a 2DOF robot manipulator. The basic idea is to determinate four optimal parameters (Kp, Ki, Kd and lamda) ensuring the best performance of a robot manipulator system, minimizing the integral time absolute error criterion (ITAE) and the integral time square error criterion (ISTE). The robot manipulator is modeled in Simulink and the control is implemented using the MATLAB environment. The obtained simulation results prove the robustness of ALO in comparison with other algorithms.
Polymer degradation: a short review
Authors: Vohlídal Jiří 
Published: December 2020

Abstract
The reader will find basic knowledge about the degradation of polymers, its causes, course and consequences in a broader context, as indicated through the list of the chapter titles: Introduction; Depolymerization; Initiated cleavage (degradation) of macromolecules; Thermal degradation; Photochemical degradation; Mechanochemical degradation; Oxidative degradation; Polymer burning; Kinetics of cleaving macromolecules when chain depolymerization is negligible; Degradation in polymer recycling; Protection of polymers against degradation.
Caputo generalized ψ-fractional integral inequalities
Authors: Anastassiou George A. 
Published: December 2020

Abstract
Very general univariate and multivariate Caputo ψ-fractional integral
inequalities of Poincaré, Sobolev and Hilbert–Pachpatte types are
presented. Estimates are with respect to

∥
⋅
∥

p

{\lVert\,\cdot\,\rVert_{p}}

,

1
≤
p
<
∞

{1\leq p<\infty}

. Applications are given.
The Impact of the Business Environment on the Formalization of Informal Firms. The Case of Kosovo
Authors: Zylfijaj Kujtim , Nikoloski Dimitar , Tournois Nadine 
Published: December 2020

AbstractThe research presented here investigates the impact of the business environment on the formalization of informal firms, using firm-level data for 243 informal firms in Kosovo. The findings indicate that business-environment variables such as limited access to financing, the cost of financing, the unavailability of subsidies, tax rates, and corruption have a significant negative impact on the formalization of informal firms. In addition, firm-level characteristics analysis suggests that the age of the firm also exercises a significant negative impact, whereas sales volume exerts a significant positive impact on the formalization of informal firms. These findings have important policy implications and suggest that the abolition of barriers preventing access to financing, as well as tax reforms and a consistent struggle against corruption may have a positive influence on the formalization of informal firms. On the other hand, firm owners should consider formalization to be a means to help them have greater opportunities for survival and growth.
It’s Time to Do News Again
Authors: Wilson Anna 
Published: December 2020

AbstractThe study analyses the RT USA show “The News with Rick Sanchez” to identify persuasive and manipulative communication strategies realised by the host’s integration of speech and co-speech gestures.What cognitive systems, conceptual processes and schemas does the speaker employ to construct and communicate viewpoint? What linguistic and gestural units enable certain viewpoint construction? What role does social context play in the interpretation of these units?After a quantitative overview of the use of body-directed and related outward-directed gestures in 180 minutes of RT recordings, the study offers a fine-grained qualitative analysis of viewpoint construction behind four situations from these RT data. It develops an advanced cognitive-linguistic approach anchored in conceptual blending (Fauconnier and Turner 2002) and the cognitive system of force dynamics (Talmy 1988, 2000). The study argues that this approach is successful in revealing speech-gesture integrations as triggering viewpoint blending for the purpose of manipulation and is useful for transferring manual qualitative analysis to analysis at scale.