bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Mobile Apps and Biosensing Devices to Monitor Physical Activity and Respiratory Function in Smokers With and Without Respiratory Symptoms or Chronic Obstructive Pulmonary Disease: Protocol for a Proof-of-Concept, Open-Label, Feasibility Study
Authors: Sharman Almaz , Zhussupov Baurzhan , Sharman Dana , Kim Irina 
Published: January 2020

Background
Chronic obstructive pulmonary disease (COPD) is a global public health problem, and continuous monitoring is essential for both its management as well as the management of other chronic diseases. Telemonitoring using mobile health (mHealth) devices has the potential to promote self-management, improve control, increase quality of life, and prevent hospital admissions.

Objective
This study aims to demonstrate whether a large-scale study assessing the use of mHealth devices to improve the treatment, assessment, compliance, and outcomes of chronic diseases, particularly COPD and cardio-metabolic syndrome, is feasible. This will allow our team to select the appropriate design and characteristics for our large-scale study.

Methods
A total of 3 cohorts, with 9 participants in each, will use mHealth devices for 90 days while undergoing the current standard of care. These groups are: 9 “non-COPD,” otherwise healthy, smokers; 9 “grey zone” smokers (forced expiratory volume in 1 second/ forced vital capacity ≥0.70 after bronchodilator treatment; COPD Assessment Test ≥10); and 9 smokers diagnosed with Stage 1-3 COPD. Rates of recruitment, retention, and adherence will be measured. Overall, two mHealth devices will be utilized in the study: the AnaMed Original Equipment Manufacturer device (measures distance, energy expenditure, heart rate, and heart rate variability) and the Air Next mobile spirometry device. The mHealth devices will be compared against industry standards. Additionally, a questionnaire will be administered to assess the participants’ perceptions of the mHealth technologies used.

Results
The inclusion of participants started in June 2019. Study results will be published in peer-reviewed scientific journals.

Conclusions
This study will demonstrate whether a large-scale study to assess the use of mHealth devices to improve the treatment, assessment, compliance, and outcomes of chronic diseases, particularly COPD and cardio-metabolic syndrome, is feasible. It will also allow the research team to select the appropriate design and characteristics for the large-scale study.

Trial Registration
ClinicalTrials.gov NCT04081961; https://clinicaltrials.gov/ct2/show/NCT04081961

International Registered Report Identifier (IRRID)
DERR1-10.2196/16461
Impact of Built Environments on Body Weight (the Moving to Health Study): Protocol for a Retrospective Longitudinal Observational Study
Authors: Mooney Stephen J , Bobb Jennifer F , Hurvitz Philip M , Anau Jane , Theis Mary Kay , Drewnowski Adam , Aggarwal Anju , Gupta Shilpi , Rosenberg Dori E , Cook Andrea J , Shi Xiao , Lozano Paula , Moudon Anne Vernez , Arterburn David 
Published: January 2020

Background
Studies assessing the impact of built environments on body weight are often limited by modest power to detect residential effects that are small for individuals but may nonetheless comprise large attributable risks.

Objective
We used data extracted from electronic health records to construct a large retrospective cohort of patients. This cohort will be used to explore both the impact of moving between environments and the long-term impact of changing neighborhood environments.

Methods
We identified members with at least 12 months of Kaiser Permanente Washington (KPWA) membership and at least one weight measurement in their records during a period between January 2005 and April 2017 in which they lived in King County, Washington. Information on member demographics, address history, diagnoses, and clinical visits data (including weight) was extracted. This paper describes the characteristics of the adult (aged 18-89 years) cohort constructed from these data.

Results
We identified 229,755 adults representing nearly 1.2 million person-years of follow-up. The mean age at baseline was 45 years, and 58.0% (133,326/229,755) were female. Nearly one-fourth of people (55,150/229,755) moved within King County at least once during the follow-up, representing 84,698 total moves. Members tended to move to new neighborhoods matching their origin neighborhoods on residential density and property values.

Conclusions
Data were available in the KPWA database to construct a very large cohort based in King County, Washington. Future analyses will directly examine associations between neighborhood conditions and longitudinal changes in body weight and diabetes as well as other health conditions.

International Registered Report Identifier (IRRID)
DERR1-10.2196/16787
Hemostatis Analyzer-Supported Hemotherapy Algorithm in Cardiac Surgery: Protocol for a Randomized Controlled Monocentric Trial
Authors: Michel Sophie , Piekarski Florian , Fischer Jan-Hendrik , Hettler Vanessa , Adam Elisabeth Hannah , Holzer Lars , Lotz Gösta , Walther Thomas , Zacharowski Kai , Raimann Florian Jürgen 
Published: January 2020

Background
Point of care devices for performing targeted coagulation substitution in patients who are bleeding have become increasingly important in recent years. New on the market is the Quantra. It is a device that uses sonorheometry, a sonic estimation of elasticity via resonance, which is a novel ultrasound-based technology that measures viscoelastic properties of whole blood. Several studies have already shown the comparability of the Quantra with devices already established on the market, such as the rotational thromboelastometry (ROTEM) device.

Objective
In contrast to existing studies, this study is the first prospective interventional study using this new system in a cardiac surgical patient cohort. We will investigate the noninferiority between an already existing coagulation algorithm based on the ROTEM/Multiplate system and a new algorithm based on the Quantra system for the treatment of coagulopathic cardiac surgical patients.

Methods
The study is divided into two phases. In an initial observation phase, whole blood samples of 20 patients obtained at three defined time points (prior to surgery, after completion of cardiopulmonary bypass, and on arrival in the intensive care unit) will be analyzed using both the ROTEM/Multiplate and Quantra systems.
The obtained threshold values will be used to develop a novel algorithm for hemotherapy. In a second intervention phase, the new algorithm will be tested for noninferiority against an algorithm used routinely for years in our department.

Results
The main objective of the examination is the cumulative loss of blood within 24 hours after surgery. Statistical calculations based on the literature and in-house data suggest that the new algorithm is not inferior if the difference in cumulative blood loss is <150 mL/24 hours.

Conclusions
Because of the comparability of the Quantra sonorheometry system with the ROTEM measurement methods, the existing hemotherapy treatment algorithm can be adapted to the Quantra device with proof of noninferiority.

Trial Registration
ClinicalTrials.gov NCT03902275; https://clinicaltrials.gov/ct2/show/NCT03902275

International Registered Report Identifier (IRRID)
DERR1-10.2196/17206
DEVELOPMENT AND EVALUATION OF NANOSPONGE LOADED TOPICAL HERBAL GEL OF WRIGHTIA TINCTORIA
Authors: IRIVENTI PADMINI , GUPTA N. VISHAL 
Published: January 2020

Objective: Psoriasis is the most common chronic autoimmune disease. The main objective of the present study was to develop Nanosponge (NS) based Topical gels of Wrightia tinctoria extract using cross-linker and polymer by melting method. It is used in treating Psoriasis.
Methods: Phytoconstituents present in the herbal extract were identified by Liquid Chromatography-Mass Spectroscopy (LC-MS) studies. In vitro drug release and Entrapment Efficiency of all NS were determined. The optimized NS were incorporated in the gel to formulate nano topical gel. Evaluation studies like homogenicity, viscosity, spreadability, pH and In vitro studies were carried out for all gel formulations.
Results: The prepared gels were transparent, had good viscosity and spreadability. SEM photographs confirmed that the prepared formulation were roughly spherical and porous in nature. In vitro diffusion studies showed drug release of 92.15% in 24 h.
Conclusion: From this study it can be concluded that constituents responsible for treating psoriasis are present in the obtained extract and prepared NS based topical gel has significant effect in providing sustained drug release.
OPTIMIZATION OF STATISTICALLY DESIGNED ACECLOFENAC FAST DISSOLVING TABLETS EMPLOYING STARCH GLUTAMATE AS A NOVEL SUPERDISINTEGRANT
Authors: KUMAR R. SANTOSH , MUDILI SAHITHI 
Published: January 2020

Objective: To optimize aceclofenac fast dissolving tablets employing starch glutamate as novel superdisintegrant by 23factorial design to improve bioavailability and enhance patient compliance.
Methods: Starch glutamate was prepared by the esterification process. Starch glutamate physical and micromeritics properties had been evaluated and the prepared starch glutamate was used as a superdisintegrant for the formulation of the fast dissolving tablets of aceclofenac by direct compression method and optimized by employing 23factorial design. The prepared aceclofenac fast dissolving tablets were evaluated for post compression parameters as well as in vitro and in vivo release characteristics. Optimized formulation stability studies were performed at accelerated conditions for 6 mo as per ICH and WHO guidelines.
Results: The prepared starch glutamate was amorphous, insoluble in aqueous and organic solvents were tested. Fast dissolving tablets of aceclofenac were formulated by employing starch glutamate as a superdisintegrant showed good tablet properties and showed an increased dissolution efficiency of the drug. Among all the formulations (F1 to F8), the formulation F8 containing 5% concentration of starch glutamate, croscarmellose sodium and, crospovidone as a superdisintegrants showed 99.7±0.15% of drug release within 5 min. Whereas the formulation F2 containing 5% concentration of starch glutamate, drug release characters were comparable to the formulation F8. Optimized formulation F2 attained peak plasma concentration within a short period and showed increased relative bioavailability of the drug.
Conclusion: From the physical properties, disintegration time, in vitro dissolution studies and pharmacokinetic studies, it was concluded that fast dissolving tablets of aceclofenac tablets formulated by employing starch glutamate as a superdisintegrant enhanced the dissolution efficiency and improved the bioavailability of the drug as compared to the pure drug and stable.
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF APREPITANT BY USING NATURAL AND SYNTHETIC SUPERDISINTEGRANTS
Authors: BALA RAJNI , SHARMA SHAILESH , IKGPTU  
Published: January 2020

Objective: The present study was aimed to formulate fast dissolving tablets (FDTs) of Aprepitant (APT) using natural and synthetic superdisintegrants with the desired onset of action, increased bioavailability by reducing the frequency of dosage and also reduce the first-pass metabolism of the drug.
Methods: In this research, the gum isolated from cordia dichotoma was investigated as super disintegrants in fast dissolving tablets (FDTs). The aprepitant tablets were prepared separately using cordia dichotoma (natural), sodium starch glycolate and croscarmellose sodium (synthetic) as superdisintegrants by direct compression method. The tablets were evaluated for various precompression and post-compression parameters.
Results: The optimized formulation (APT F3) of cordia dichotoma (8%) showed satisfactory physicochemical properties, minimum disintegration time (34 seconds) and highest dissolution rate (86.52%) in 10 min than the other synthetic superdisintegrants. Also, the pharmacokinetic study of the optimized formulation showed effective results as compared with marketed product of aprepitant.
Conclusion: The developed formulation can improve the onset of action as well as improve patient compliance.
IMPLEMENTATION OF QUALITY BY DESIGN (QBD) APPROACH IN FORMULATION AND DEVELOPMENT OF RITONAVIR PELLETS USING EXTRUSION SPHERONIZATION METHOD
Authors: MANDLIK SATISH K. , AGARWAL PAYAL P. , DANDGAVHAL HARSHAL P. 
Published: January 2020

Objective: Ritonavir is an antiretroviral drug used for HIV-AIDS treatment. The purpose of this research work was to implement the quality by design (QbD) approach in formulation of ritonavir sustained-release pellets by industrially applied extrusion spheronization technique.
Methods: Pellets were prepared by extrusion spheronization method and evaluated for their physicochemical properties. Initially, on the basis of prior knowledge Quality Target Product Profile (QTTP) element was identified and further Critical Quality Attributes (CQA) elements were defined. Risk assessment (RA) was done by two tools as failure mode and effect analysis (FMEA) and fishbone diagram (Ishikawa plot). Placket Burman design was implemented as a screening design using seven high-risk factors (spheronization speed, spheronization time, extrusion speed, drying method, PVP K 30, cross povidone, and solvent). Optimization study was done by 23 full factorial design with three critical factors as (spheronization speed, extrusion speed and PVP K 30). The in vitro drug release was studied in both gastric and intestinal fluids for 12 h using USP Ι apparatus. Control space was established for the sustained release pellets.
Results: Among all batches obtained in 23 full factorial design, batch R7 was found to be effective with carr’s index value of 5.281, percentage yield of 69.6%, time required to release 50% drug was 8 h and percent drug release after 12 h was found 83.132 %, R7 batch was selected as optimized batch. Statistical analysis showed model terms were significant.
Conclusion: We can conclude that; sustained-release pellets of ritonavir were successfully designed using QbD approach.
Hubungan Tingkat Kecemasan Dengan Hemodinamik Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisa
Authors: Nurlinawati Nurlinawati , Rudini Dini , Yuliana Yuliana 
Published: January 2020

Latar Belakang : Pasien hemodialisis seringkali mengalami kecemasan. Kecemasan ini apabila tidak diatasi akan mempengaruhi aspek fisiologis dan hemodinamik yang dikhawatirkan akan menimbulkan komplikasi yaitu dialysis disequilibrium syndrome. Penelitian ini bertujuan untuk mengetahui hubungan tingkat kecemasan dengan kondisi hemodinamik pasien gagal ginjal kronik yang sedang menjalani hemodialisa. Metode : Jenis penelitian kuantitatif dengan menggunakan cross sectional. Sampel dalam penelitian ini berjumlah 57 responden. Analisis univariat menggunakan distribusi frekuensi dan analisis bivariat menggunakan regresi linier sederhana. Hasil : Hasil penelitian didapat tingkat kecemasan hanya berhubungan dengan Mean Arterial Pressure (MAP) sebelum hemodialisis dengan nilai signifikan 0.023 dan sesudah hemodialisis didapatkan nilai signifikan 0.026. Sedangkan nadi dan respirasi rate tidak terdapat hubungan dengan nilai signifikan >0.05. Kesimpulan : Ada hubungan antara tingkat kecemasan dengan Mean Arterial Pressure (MAP) pasien gagal ginjal kronik yang sedang menjalani hemodialisa di ruang Hemodialisa RSUD Raden Mattaher Jambi Tahun 2018.
Motivasi Widyaiswara Dalam Penulisan Karya Tulis Ilmiah Pada Badan Pengembangan Sumber Daya Manusia Provinsi Jambi
Authors: Asnofidal Asnofidal 
Published: January 2020

Pembuatan karya tulis ilmiah merupakan bagian dari tugas dan kewajiban bagi widyaiswara, karena mereka berfungsi sebagai pengembang sumber daya manusia aparatur sipil negara. Membuat karya tulis ilmiah memerlukan motivasi yang kuat, karena ia merupakan tugas yang memerlukan konsentrasi penuh. Penelitian ini tentang motivasi widyaiswara Badan Pengembangan Sumber Daya Manusia (BPSDM) Provinsi Jambi untuk membuat karya tulis ilmiah. Data diperoleh melalui Wawancara, Observasi, Focus Group Siscussion (FGD) dan Studi Pustaka. Informan dipilih secara porpusive sampling dan dianalisis dengan metode trianggulasi. Hasil penelitian memperoleh bahwa widyaiswara BPSDM Provinsi Jambi memiliki motivasi instrinsik untuk membuat karya tulis ilmiah yang muncul dari dalam dirinya sendiri, yaitu untuk peningkatan kompetensi diri, karir dan kenaikan pangkat. Selain itu, widyaiswara juga memiliki motivasi ekstrinsik untuk membuat karya tulis ilmiah, yaitu dukungan lingkungan yang nyaman, fasilitas atau sarana dan prasarana yang cukup, dan dukungan kebijakan pimpinan BPSDM Provinsi Jambi dengan berbagai program dan ketersediaan anggaran. Dalam rangka meningkatkan motivasi widyaiswara BPSDM Provinsi Jambi untuk membuat karya tulis ilmiah perlu disarankan beberapa hal sebagai berikut: pengaturan jadwal widyaiswara untuk mengajar secara struktural, sehingga setiap tahun widyaiswara dapat menghasilkan karya tulis ilmiah, mengikutserta widyaiswara dalam setiap kegiatan pertemuan ilmiah seperti seminar dan konferensi baik di dalam daerah maupun di luar daerah, menyediakan anggaran penelitian dan pembuatan karya tulis ilmiah, dan sangat penting memasukkan karya tulis ilmiah sebagai beban kinerja widyaiswara yang harus dimuatkan dalam Sasaran Kinerja Pegawai (SKP).
Studi Komparatif Mediasi Antara Peraturan Mahkamah Agung (PERMA) Nomor I Tahun 2008 Dan Peraturan Mahkamah Agung (PERMA) Nomor I Tahun 2016
Authors: Alissa Evalina , Erwita Yerni 
Published: January 2020

Mediasi sebagai instrumen penyelesaian sengketa berdasarkan ketentuan Pasal 130 HIR dan Pasal 154 Rbg yang mewajibkan hakim untukterlebih dahulu mendamaikan para pihak yang berperkara sebelum perkaranya diperiksa. Diundangkannya PERMA No. I Tahun 2008 dan diperbaharui dengan PERMA No.ITahun 2016 yang memberikan panduan tentang penjelasan prosedur mediasi bagi para pihak untuk menyatakan perdamaian. Objek masalah hukum dalam penelitian ini adalah menganalisis perbandingan substansi dari dua Peraturan Mahkamah Agung, dan menganalisis efektivitas mediasi sebagai solusi untuk mengurangi akumulasi kasus sehingga mewujudkan proses peradilan yang cepat dan murah. Pendekatan penelitian yang dilakukan adalah statuta dan pendekatan konseptual terhadap materi hukum yang telah dikumpulkan melalui penelitian kepustakaan. Hasil penelitian menunjukkan bahwa ada beberapa pengaturan tentang mediasi, yang telah mengalami perubahan dalam Peraturan Mahkamah Agung Nomor I Tahun 2016 adalah: (1) kewajiban untuk memberikan formulir penjelasan hakim ketua majelis tentang mediasi dan formulir pernyataan para pihak tentang penjelasan mediasi yang wajib ditanda tangani para pihak, (2)mempersingkat waktu mediasi, kewajiban para pihak untuk secara langsung menghadiri pertemuan mediasi, (3) adanya niat baik dalam proses mediasi serta konsekuensi hukum jika niat baik ini dilanggar. Implementasi mediasi belum dapat menjadi sarana yang efektif untuk mengurangi akumulasi kasus perdata karena masih banyak kendala, termasuk rendahnya tingkat pemahaman dan kesadaran masyarakat tentang fungsi mediasi. Oleh karena itu, peran aktif hakim yang ditunjuk sebagai mediator untuk memberikan pemahaman dan pengetahuan yang benar tentang manfaat dan fungsi mediasi dalam sistem hukum perdata di Indonesia sehingga peradilan yang cepat dan murah dapat diwujudkan.
The Correlation Between Reading Comprehension Ability and Vocabulary Class IX At SMP N 6 Jambi
Authors: Dewi Kartika 
Published: January 2020

The main purpose of this study was to find out whether there is any correlation between Reading Comprehension and vocabulary class IX at SMP N 6 Jambi. The hypotheses of this study are, (1) there is no correlation between reading comprehension and vocabulary (2) there is any correlation between vocabulary mastery and reading comprehension. The problem of this research study was: is there any correlation between reading comprehension and vocabulary class IX at SMP N 6 Jambi? The population of this research was 373 students. The sample of this research was 76 students which were taken cluster random sampling from two classes. To conduct this study, qualitative method was used. The data were analyzed by using, Pearson Moment Product Bivariate with SPSS. Based on the findingit was found that the average score reading comprehension test was 56, 5 and the score vocabulary test was 52, 9 .it means that the students' reading comprehension was fair. And the students' competency in vocabulary was fair. Based on the finding, it was found that the correlation coefficient obtained is 0.001. It shows that there is no correlation between vocabulary mastery and reading comprehension and vocabulary.
Mutu Minyak Jelantah Dengan Adsorben Biji Salak (Salacca zalacca (Gaertn.)Voss) menggunakan Parameter Bilangan Peroksida dan Asam Lemak Bebas
Authors: Ihwan Ihwan , Fadlia Fadlia , Anam Syariful 
Published: January 2020

Quality of used cooking oil with snake fruit (Salacca zalacca (Gaertn.) Voss) seed adsorbent has been conducted. This study aims to determine the ability of snake fruit seed in reducing peroxide value and free fatty acids in used cooking oil which can improve the quality and extend usage lifespan of the used cooking oil. The oil sampled in this study was packaged cooking oil which is usually used to fry food untill 7th frying. The oil was then neutralized using snake fruit activated charcoal. The test refers to the Indonesian National Standard (SNI) 7709: 2012 as the quality requirements of cooking oil. The results showed that snake fruit activated charcoal can reduce peroxide value as much as 56.18% and free fatty acid 76.04% in the used cooking oil.
Motivasi Kepesertaan Mandiri BPJS di Era Universal Health Coverage Jaminan Kesehatan Nasional
Authors: Dahliana Anita 
Published: January 2020

Abstract. This research was conducted to determine the motivation of BPJS Health participants as independent participants. In this study, researchers used a motivational theory developed by Clayton Alderfer with three indicators namely Existence, Relatedness and Growth with a descriptive quantitative research approach with non-random sampling using a purposive method using conditions in selecting respondents ie respondents were outpatients in Specialist Poly Wiyung Hospital, Surabaya. The selected respondents were 43 people.The results of this study were the discovery of community motivation as independent health insurance participants.
Abstrak. Penelitian ini dilakukan untuk mengetahui motivasi peserta BPJS Kesehatan sebagai peserta mandiri. Pada penelitian ini, peneliti menggunakan teori motivasi yang dikembangkan oleh Clayton Alderfer dengan tiga indikator yaitu Existence, Relatedness dan Growth dengan pendekatan penelitian kuantitatif deskriptif. Teknik pengambilan sampel non-random menggunakan cara purposive, yakni pemilihan responden menggunakan syarat tertentu (responden adalah pasien rawat jalan di Poli Spesialis RS Wiyung Surabaya). Responden yang dipilih berjumlah 43 orang. Hasil penelitian ini menunjukkan adanya motivasi masyarakat yang menjadi peserta mandiri jaminan kesehatan.
Escândalo na Academia Imperial de Belas Artes: uma expulsão por manifesta desobediência
Authors: Chillón Alberto Martín 
Published: January 2020

Em 12 de dezembro de 1838, Bernardo Pereira de Vasconcelos (1795-1850), ministro interino do Império, decidiu o castigo que deveria ser imposto ao aluno de escultura da Academia Imperial de Belas Artes, Honorato Manoel de Lima, por seu descomedido procedimento e manifesta desobediência, excluíndo-o para sempre de dita Academia. Este documento se conserva, assim como a produção documental da Academia Imperial de Belas Artes, no Arquivo Histórico da Escola de Belas Artes da Universidade Federal do Rio de Janeiro, acervo fundamental para o estudo da arte brasileira dos séculos XIX e XX e para a história do ensino artístico no Brasil.