bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insulin‐stimulated glucose uptake partly relies on p21‐activated kinase (PAK)2, but not PAK1, in mouse skeletal muscle
Authors: Møller Lisbeth L. V. , Jaurji Merna , Kjøbsted Rasmus , Joseph Giselle A. , Madsen Agnete B. , Knudsen Jonas R. , Lundsgaard Anne‐Marie , Andersen Nicoline R. , Schjerling Peter , Jensen Thomas E. , Krauss Robert S. , Richter Erik A. , Sylow Lykke 
Published: August 2020

Key points
Muscle‐specific genetic ablation of p21‐activated kinase (PAK)2, but not whole‐body PAK1 knockout, impairs glucose tolerance in mice.
Insulin‐stimulated glucose uptake partly relies on PAK2 in glycolytic extensor digitorum longus muscle
By contrast to previous reports, PAK1 is dispensable for insulin‐stimulated glucose uptake in mouse muscle.
AbstractThe group I p21‐activated kinase (PAK) isoforms PAK1 and PAK2 are activated in response to insulin in skeletal muscle and PAK1/2 signalling is impaired in insulin‐resistant mouse and human skeletal muscle. Interestingly, PAK1 has been suggested to be required for insulin‐stimulated glucose transporter 4 translocation in mouse skeletal muscle. Therefore, the present study aimed to examine the role of PAK1 in insulin‐stimulated muscle glucose uptake. The pharmacological inhibitor of group I PAKs, IPA‐3 partially reduced (–20%) insulin‐stimulated glucose uptake in isolated mouse soleus muscle (P < 0.001). However, because there was no phenotype with genetic ablation of PAK1 alone, consequently, the relative requirement for PAK1 and PAK2 in whole‐body glucose homeostasis and insulin‐stimulated muscle glucose uptake was investigated. Whole‐body respiratory exchange ratio was largely unaffected in whole‐body PAK1 knockout (KO), muscle‐specific PAK2 KO and in mice with combined whole‐body PAK1 KO and muscle‐specific PAK2 KO. By contrast, glucose tolerance was mildly impaired in mice lacking PAK2 specifically in muscle, but not PAK1 KO mice. Moreover, while PAK1 KO muscles displayed normal insulin‐stimulated glucose uptake in vivo and in isolated muscle, insulin‐stimulated glucose uptake was slightly reduced in isolated glycolytic extensor digitorum longus muscle lacking PAK2 alone (–18%) or in combination with PAK1 KO (–12%) (P < 0.05). In conclusion, glucose tolerance and insulin‐stimulated glucose uptake partly rely on PAK2 in glycolytic mouse muscle, whereas PAK1 is dispensable for whole‐body glucose homeostasis and insulin‐stimulated muscle glucose uptake.
Tilting Pad Journal Bearing Misalignment Effect on Thermally Induced Synchronous Instability (Morton Effect)
Authors: Shin Dongil , Palazzolo Alan B. 
Published: August 2020

Abstract
This paper investigates the influence of misaligned journal bearing effects on the thermally induced rotor instability (Morton effect “ME”) problem. The Morton effect is caused by uneven viscous heating of the journal in a fluid film bearing, which causes thermal bending, especially in rotors with an overhung disc or coupling weight. The thermally induced bending in the shaft may cause a vibration instability, which results in an excessive level of synchronous vibration. Previous research focused on parametric studies of the rotor and bearing design parameters, including overhung mass, bearing radial clearance, and lubricant viscosity. The present study investigates the influence of journal misalignment on the Morton effect. A coupled fluid-thermal-structural, three-dimensional finite element model (FEM) is developed to simulate fluid film pressures and temperatures, and shaft temperatures and vibrations. Simulations were conducted with different ratios of journal misalignment, and different pad-pivot types to determine their effect on the phenomenon. The simulation results indicate that the amplitude of the misalignment angle affects the instability speed range (ISR) caused by the Morton effect under certain conditions.
A Review of Journal Bearing Thermal Effects on Rotordynamic Response
Authors: Shin Dongil , Yang Jongin , Tong Xiaomeng , Suh Junho , Palazzolo Alan 
Published: August 2020

AbstractTraditional analysis of journal bearings assumed a constant viscosity which simplified the solutions for static and dynamic characteristics and responses. Today's high-performance machinery requires more accurate models wherein temperature and viscosity distributions in the film must be calculated. Thermal effects in journal bearings have a strong influence on both static and dynamic properties, and consequently play a critical role in determining rotor-bearing system performance. This paper presents an extensive survey of the thermal modeling methods and effects in journal bearings. The subjects include various bearing types, and recent progress in thermal bearing design and thermal instability problems observed in fluid and gas film hydrodynamic bearings. The extent of the survey ranges from conventional Reynolds equation models to more advanced computational fluid dynamics models.
An Optimal Model Identification Algorithm of Nonlinear Dynamical Systems With the Algebraic Method
Authors: Leylaz Ghazaale , Ma Shangjie (Frank) , Sun Jian-Qiao 
Published: August 2020

Abstract
This article proposes a nonparametric system identification technique to discover the governing equation of nonlinear dynamic systems with the focus on practical aspects. The algorithm builds on Brunton’s work in 2016 and combines the sparse regression with an algebraic calculus to estimate the required derivatives of the measurements. This reduces the required derivative data for the system identification. Furthermore, we make use of the concepts of K-fold cross validation from machine learning and information criteria for model selection. This allows the system identification with less measurements than the typically required data for the sparse regression. The result is an optimal model for the underlining system of the data with a minimum number of terms. The proposed nonparametric system identification method is applicable for multiple-input–multiple-output systems. Two examples are presented to demonstrate the proposed method. The first one makes use of the simulated data of a nonlinear oscillator to show the effectiveness and accuracy of the proposed method. The second example is a nonlinear rotary flexible beam. Experimental responses of the beam are used to identify the underlining model. The Coulomb friction in the servo motor together with other nonlinear terms of the system variables are found to be important components of the model. These are, otherwise, not available in the theoretical linear model of the system.
Operational Transfer Path Analysis Based on Signal Decoupling
Authors: Song Leiming , Gui Qing , Chen Hao , Bai Haifei , Sun Yu 
Published: August 2020

Abstract
This study proposes an input decoupling analysis method based on the pulse test and the traditional operational transfer path analysis (OTPA) method for the OTPA transmission path analysis when the input is strongly coupled, and the algorithm is verified for analysis optimization of results. An experimental model of the dual excitation source is established in the laboratory. Experimental comparison studies show that the OTPA method, which is based on signal decoupling, inhibits the influence of cross-coupling among the source signals during OTPA analysis and effectively improves the accuracy of the transmission path test and analysis. The OTPA method is applied to analyze the transfer path of the vibration and noise of the carriages of the electric multiple unit (EMU) train (a high-speed train in China). The false peak frequency in the traditional OTPA method is eliminated, and the accuracy of the analysis is improved.
A Green’s Function Solution for Acoustic Attenuation by a Cylindrical Chamber With Concentric Perforated Liners
Authors: Veerababu D. , Venkatesham B. 
Published: August 2020

Abstract
In this study, a Green’s function-based semi-analytical method is presented to predict the transmission loss (TL) of a circular chamber having concentric perforated screens. Initially, the Green’s function is developed for a single-screen configuration as the summation of eigenfunctions of the inner pipe in the absence of the mean flow. The inlet and the outlet ports are modeled as oscillating piston sources. A transfer matrix is formulated from the velocity potential generated by the piston sources. The results obtained from the proposed method are validated with the numerical and analytical models and with the experimental results available in the literature. Later, the method has been extended to the double-screen configuration. The effect of the additional perforated screen on the TL is studied in terms of the surface impedance of the chamber. Along with grazing flow considerations, guidelines are provided to incorporate more concentric perforated screens into the formulation.
Optimal Energy Dispatch Controller for Fuel Cell-Integrated Multi-Zone Building
Authors: Lin Yashen , Chinde Venkatesh , Huang Sen 
Published: August 2020

Abstract
Stationary fuel cells provide potential opportunities for energy savings when integrated with buildings. Through smart dispatch of both electrical power and heat generated by the fuel cells and managing the building loads, the buildings can achieve more efficient operation. In this paper, we develop an optimal energy dispatch controller to operate a fuel cell-integrated building. The controller leverages the inherent thermal storage and the dispatchable fuel cell to reduce its operating cost and to allow the building to participate in grid services. The proposed controller is implemented on two types of commercial buildings, a large office building and a large hotel, and the effectiveness of the controller is demonstrated through simulations. The results also indicate that the potential saving varies significantly with different system parameters, including season, fuel prices, and equipment sizing, which provide helpful insights for building operators and other stake holders.
Three-Dimensional Profilometry Utilization on VVER Type Reactors
Authors: Brom Jaroslav , Patera Jan , Zahrádka Pavel 
Published: August 2020

Abstract
The paper is focused on the application of three-dimensional (3D) profilometry on water–water energetic reactor (VVER) type nuclear power plant (NPP) equipment. This method is becoming increasingly used in the power industry and replaces conventional methods such as micrometer measurements. One of the greatest benefits is the accurate recording of the 3D profile of the measured surface and the possibility of its comparison with the production documentation or with the results from previous measurements. Centrum Výkumu Řež, s.r.o. (Research Center Řež) uses 3D laser scanner with a measuring arm. This method was, for example, successfully used for reactor pressure vessel (RPV), steam generator (SG), and bolts. The results are used by the NPP operator for the lifetime management of the primary circuit components.
Fetal haemoglobin and bronchopulmonary dysplasia in neonates: an observational study
Authors: Hellström William , Martinsson Tobias , Hellstrom Ann , Morsing Eva , Ley David 
Published: August 2020

ObjectiveEarly decrease in fetal haemoglobin (HbF) is an indicator of loss of endogenous blood components that might have predictive value for development of bronchopulmonary dysplasia (BPD). The link between HbF and BPD has not been evaluated.DesignRetrospective observational study.SettingTertiary level neonatal intensive care unit, referral centre for Southern Sweden.Patients452 very preterm infants (<30 gestational weeks) born 2009–2015.InterventionsRegular clinical practice.Main outcome measuresMean HbF, haemoglobin (Hb) and partial oxygen pressure (PaO2) levels calculated from 11 861 arterial blood gas analyses postnatal week 1. Relationship between HbF (%) and BPD (requirement of supplemental oxygen at 36 weeks’ postmenstrual age) and the modifying influence of PaO2 (kPa) and total Hb (g/L) was evaluated.ResultsThe mean gestational age (GA) at birth was 26.4 weeks, and 213 (56%) infants developed BPD. A 10% increase in HbF was associated with a decreased prevalence of BPD, OR 0.64 (95% CI 0.49 to 0.83; p<0.001). This association remained when adjusting for mean PaO2 and Hb. Infants with an HbF in the lowest quartile had an OR of 27.1 (95% CI 11.6 to 63.4; p<0.001) for development of BPD as compared with those in the highest quartile. The area under the curve for HbF levels and development of BPD in the full statistical model was 0.871.ConclusionsEarly rapid postnatal decline in HbF levels was associated with development of BPD in very preterm infants. The association between HbF and BPD was not mediated by increased oxygen exposure. The potential benefit of minimising loss of endogenous blood components on BPD outcome will be investigated in a multicentre randomised trial.
Gas flow in preterm infants treated with bubble CPAP: an observational study
Authors: Payne Cameron D , Owen Louise S , Hodgson Kate Alison , Morley Colin J , Davis Peter G , Manley Brett James 
Published: August 2020

ObjectiveTo measure the nasal gas flow in infants treated with bubble continuous positive airway pressure (CPAP) and compare it with commonly used flows during nasal high flow (nHF) treatment.DesignThis is a prospective, single-centre study. Bubble CPAP pressure was measured at the nasal prongs. Set gas flow was reduced until bubbling in the water chamber just ceased. Set gas flow without bubbling then approximated flow entering the infant’s nose (‘delivered flow’).SettingNeonatal intensive care at The Royal Women’s Hospital, Melbourne, Australia.PatientsClinically stable preterm infants receiving bubble CPAP therapy.Main outcome measureDelivered flow (L/min) when bubbling stopped at a range of clinically set CPAP pressures (cm H2O).ResultsForty-four infants were studied, with a mean (SD) gestational age at birth of 28.4 (2.2) weeks and birth weight of 1154 (419) g. At the time of the study, infants had a median (IQR) age of 4.5 (2–12) days and a mean (SD) weight of 1205 (407) g. Delivered flow ranged from 0.5 to 9.0 L/min, and increased with higher set CPAP pressures (median 3.5 L/min at CPAP 5 cm H2O vs 6.3 L/min at CPAP 8 cm H2O) and heavier weights (median 3.5 L/min in infants <1000 g vs 6.5 L/min for infants >1500 g).ConclusionsNasal gas flows during bubble CPAP in preterm infants are similar to flows used during nHF and increase with higher set bubble CPAP pressures and in larger infants.Trial registration numberACTRN12619000197134.
Ethical issues for large-scale hearing aid donation programmes to the Pacific Islands: a Samoan perspective
Authors: Kaspar Annette , Pifeleti Sione , Faumuina Penaia A , Newton Obiga , Driscoll Carlie 
Published: August 2020

The Pacific Islands are estimated to have among the highest global burdens of hearing loss, however, hearing health services are limited throughout this region. The provision of hearing aid is desirable, but should be delivered in accordance with WHO recommendations of appropriate and locally sustainable services. Large-scale hearing aid donation programmes to the Pacific Islands raise ethical questions that challenge these recommendations.The aim of this paper is to consider the ethical implications of large-scale hearing aid donation programmes to Samoa, a nation of the Pacific Islands. Evaluation of both ‘Western’ and ‘Pacific Island’ perspectives reveals important cross-cultural differences regarding attitudes to donation programmes. We attempt to offer possible solutions that satisfy both ethical frameworks, and which should enable us to deliver an effective hearing health service for Samoa. These solutions may be translational and benefit other Pacific Island nations in a similar context.
Ambulatory blood pressure monitoring among emergency medical services night shift workers
Authors: Patterson P Daniel , Mountz Kristina A , Agostinelli Michael G , Weaver Matthew D , Yu Yi-Chuan , Herbert Brandon M , Markosyan Mark A , Hopkins David R , Alameida Alana C , Maloney III John A , Martin Sarah E , Brassil Bridget N , Martin-Gill Christian , Guyette Francis X , Callaway Clifton W , Buysse Daniel J 
Published: August 2020

ObjectivesHigher 24-hour blood pressure (BP) and blunted BP dipping during sleep and night-time hours are associated with adverse health outcomes. Night shift work may affect 24-hour BP and dipping patterns, but empirical data in emergency medical services (EMS) clinician shift workers are sparse. We implemented ambulatory blood pressure monitoring (ABPM) in EMS workers to characterise BP during night shift work versus a non-workday, and sleep versus wake.MethodsParticipants worked night shifts. Hourly ABPM and wrist actigraphy (to measure sleep) were collected during two 24-hour periods, one scheduled night shift and one non-workday. Blunted BP dipping was defined as a BP decrease of <10%.ResultsOf 56 participants, 53 (53.6% female, mean age 26.5 (SD 7.5) years) completed the study. During daytime sleep on a workday, 49.1% of participants had blunted systolic BP (SBP) or diastolic BP (DBP) dipping. During night-time sleep on a non-workday, 25% had blunted SBP dipping and 3.9% blunted DBP dipping. Blunted SBP or DBP dipping occurred among all participants who did not nap during the night shift or who napped <60 min. Blunted SBP dipping occurred in only 14.3% of participants who napped 60–120 min.ConclusionsDuring night shift work, the BP dipping of EMS shift workers is blunted; however, most who nap for 60 min or longer experience a healthy dip in BP. The potential health consequences of these observations in EMS clinicians warrant further study.
Role of occupational exposures in lung cancer risk among women
Authors: Xu Mengting , Ho Vikki , Siemiatycki Jack 
Published: August 2020

ObjectivesTo explore possible associations between selected occupational agents and lung cancer risk among women.MethodsA population-based case–control study on lung cancer was conducted from 1996 to 2001 in Montreal, Canada. Cases were individuals diagnosed with incident lung cancer and population controls were randomly selected from electoral lists and frequency-matched to age and sex distributions of cases. Questionnaires on lifetime occupational history, smoking and demographic characteristics were collected during in-person interviews. As part of a comprehensive exposure assessment protocol, experts reviewed each subject’s work history and assessed exposure to many agents. The current analysis, restricted to working women in the study, includes 361 cases and 521 controls. We examined the association between lung cancer and each of 22 occupational exposures, chosen because of their relatively high prevalences among these women. Each exposure was analysed in a separate multivariate logistic regression model, adjusted for smoking and other selected covariates.ResultsThere were few elevated OR estimates between lung cancer and any of the agents, and none were statistically significant, although the limited numbers of exposed women engendered wide CIs.ConclusionsThere was little evidence to suggest that women in this population had experienced excess risks of lung cancer as a result of their work exposures. However, the wide CIs preclude any strong inferences in this regard.
Association between response rates and monetary incentives in sample study: a systematic review and meta-analysis
Authors: Jia Pengli , Furuya-Kanamori Luis , Qin Zong-Shi , Jia Peng-Yan , Xu Chang 
Published: August 2020

ABSTRACTObjectiveTo investigate the effect of monetary incentive and the dose–response relationship of participants’ response rates in surveys.MethodsThree databases were searched for randomised controlled trials (RCTs) that investigated the effect of monetary incentives on participants’ first and final response rates. First response is defined as the responses after the participant was initially contacted and final response is defined as the responses after several reminders were sent. The potential dose–response relationship of the amount of monetary incentive on the relative response rate (RRR) was established by fitting a restricted cubic spline function based on the robust-error meta-regression model.Results105 RCTs were identified. The first RRR increased by 49% (RRR=1.49; 95% CI 1.29 to 1.72) when monetary incentives were provided. Dose–response analysis revealed that an amount between US$6.25 and US$8 had the maximum effect on increasing the first response rate. On average, the final RRR increased almost by 20% (RRR=1.18; 95% CI 1.11 to 1.25) with monetary incentive compared to no-monetary incentive. An amount between US$10 and US$15 had the maximum effect on the final response rate, with an increase in the final RRR of 34% (RRR=1.34; 95% CI 1.19 to 1.51). There was a significant increase in the response rate when two or more reminders were sent.ConclusionMonetary incentives and reminders improve the response rates. Future studies need to consider providing monetary incentives and sending at least two reminders to increase the response rate and reduce the chances of non-response bias.
Tobacco farming and current debt status among smallholder farmers in Manicaland province in Zimbabwe
Authors: Chingosho Rutendo , Dare Chengetai , van Walbeek Corné 
Published: August 2020

IntroductionZimbabwe is the largest producer of tobacco leaf in Africa and the sixth largest globally. Tobacco leaf is a mainstay of the economy, accounting for about 10% of the country’s GDP in 2018.MethodsWe use descriptive and regression analyses from a face-to-face survey of 381 smallholder farmers in three major tobacco-farming areas in Manicaland province to determine the prevalence of tobacco-related debt and some of its covariates. The survey was conducted in June and July 2019.Results74% of respondents are contract farmers and 26% are independent farmers. 57% of respondents indicated that they were in tobacco-related debt. The likelihood of being in tobacco-related debt is significantly more than average for farmers with the following characteristics (holding other characteristics constant): being a contract farmer, having a larger farm, employing only family labour and not recording expenses (as a proxy for financial sophistication). 91% of contract farmers would prefer to be independent farmers, while 63% of independent farmers would prefer to be contract farmers.ConclusionThere is no evidence to suggest that tobacco growing, in its current state, has benefited the tobacco farmers in Manicaland province. Tobacco farmers are largely victims, rather than beneficiaries, of the sector. There is a strong case for government intervention to improve the conditions of tobacco farmers, either through direct intervention in the tobacco-growing sector, or by encouraging and promoting crop substitution.