bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Propagation Prediction and Assessment Method with Imported Cases and Infection Generations: Shanxi Province as a Case
Authors: Zhang Juan , Sun Gui-Quan , Li Mingtao , Zhang Wenyi , Chang Lili , Jia Zhongwei , Magalhães Ricardo J Soares , Zhang Juping , Ren Huarong , Pei Xin , Cao Xiaochun , Zhang Fenfen , Zhang Zi-Ke , Liu Guirong , Yao Meiping , Jin Zhen 
Published: March 2020

Abstract
When everyone focuses on 2019 coronavirus disease (COVID-19) in Hubei province, the epidemic in other province cannot be ignored, which also has an impact on the epidemic in the whole country. The most distinctive epidemic characteristic in all regions except Wuhan is that the most of confirmed cases are imported cases from Wuhan, and the propagation chain is relatively clear. Based on detailed contact tracing information of confirmed cases, combined with first-order outbreak response measures, we establish a disease transmission dynamical model to describe the infection propagation chain among the human population. Using Shanxi province as a case, modeling results indicate that the epidemic peak in Shanxi province occurred in February 2. In addition, our model suggests that according to the current development trend, COVID-19 will disappear in February with the final epidemic number of approximately 175 cases. It is verified that the most effective outbreak control measures in Shanxi include home isolation of people, surveillance and isolation of second-generation cases, contact tracing and management of contacts. With the end of the holiday, if the average number of contacts per person per day is less than 6 , it has little impact on the incidence of COVID-19, and even if third- and fourth-generation cases occur, the epidemic will be under control, no later than late March with a finial outbreak size of 220 cases. However, if the average number of contacts per person per day is greater than 6, the number of COVID-19 cases will continue to be reported resulting in another epidemic peak. Through the forecast and evaluation of COVID-19 in Shanxi, it is verified that the model with infection generations is more accurate to describe the spread mode and can be extended to regions with imported cases.
The correlation between IL-33 and inflammation factors in rheumatoid arthritis patients in vivo and in fibroblast-like synoviocytes in vitro
Authors: Wu Jing , Li Qiang , Deng Jia-Xin , Zhao Jin-Jun , Yu Qing-Hong 
Published: March 2020

Abstract
Background: Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines whose role remains controversial in rheumatoid arthritis (RA), because no clear conclusion has been established regarding the relationship between IL-33 and other cytokines and chemokines. The present study was conducted to evaluate the correlation of IL-33 with other cytokines and chemokines in serum and the synovia, and to explore the nature of the relationship.Results: IL-33 was found to exhibit an inverted-U-shaped correlation with multiple cytokines and chemokines in synovial fluid, including IL-6, IL-1β, CXCL8 (IL-8), CXCL9 (MIG) and CXCL10 (IP-10), but not in serum. Moreover, in vitro experiments confirmed that IL-33 also exhibits U-type dose-dependent regulation of FLS function.Conclusions: IL-33 exhibit an inverted-U-shaped correlation with multiple cytokines and chemokines in synovial fluid of RA patients. IL-33 affects the secretion of cytokines and chemokines in the synovium in a U-type dose-dependent relationship.
A retrospective study of acral melanoma that happened on foot
Authors: Weitao Yao , Qiqing Cai , Jiaqiang Wang , Peng Zhang , Xin Wang , Xinhui Du , author) Niu Xiaohui (co-corresponding 
Published: March 2020

Abstract
Methods: The aim was to investigate the epidemiological, clinical, and prognostic features of acral melanoma (AM) that occurred on foot, and to provide associated data for further study. A retrospective study was performed on patients with malignant melanoma (MM) who were treated in our hospital from January 2015 to January 2019. The tumor site was screened by foot. Basic data (e.g., gender, age, occupation, tumor location and etiology) of eligible patients, tumor-related data (such as tumor thickness, lymph node metastasis, and systemic metastasis), surgical related data (e.g., surgical site, operation time, bleeding volume, postoperative drainage time and volume), and prognostic data (including local recurrence or metastasis) were extracted. Survival analysis was used to study event-free survival (EFS) and overall survival (OS) and factors influencing survival of patients.
Results: A total of 109 patients with AM happened on foot, including 52 males and 57 females, male/female = 0.91, were involved. The patients’ age was 58.31±12.13 years old. The occupations included 69 (63.3%) of farmers, 20 (18.3%) of freelance work, 4, 10 and 6 (18.4% in total) of others, including workers, students, and retirees. Tumor locations were 19 (17.4%) of the thumbs, 9 (8.3%) of other toes, 54 (49.5%) of the inner and outer soles, 20 (18.3%) of the heels, and 7 (6.4%) of the back foot. The causes were 57 cases (52.3%) of malignant nevus, 7 cases (6.4%) of trauma stimulation, and 45 cases (41.3%) without inducement. Additionally, 29 cases (26.6%) were newly diagnosed and treated in our hospital, and 80 cases (73.4%) were previously treated in external hospitals. Symptoms of nudes or ulceration lasted for 1 to 15 months, with an average of 5.92 months. The main surgical methods are tumor (enlarged) resection, lymph nodes resection, and combined resection of tumor and lymph nodes. During the treatment, 45 patients needed additional surgery. At the last follow-up, 8 cases had tumor recurrence, 43 cases had lymph node metastasis, 29 patients (stage IV) had metastasis in vital viscera, and 12 patients died. The EFS was 16 months, and OS was 31 months on average. Univariate analysis suggested that there was a correlation between occupations and EFS, locations and OS.
Conclusions: Middle-aged and elderly manual workers were found as the main population of AM that happened on foot. The tumor appeared at the weight-bearing area of the soles and heels. The proportion of metastasis was high, while the prognosis was poor. Preventive resection of precancerous lesions and early diagnosis and treatment of tumors are the primary tasks to improve the efficacy and survival of patients
Analysis of immediate and long-term outcomes of perimesencephalic subarachnoid hemorrhage according to the hospital register data
Authors: Kulesh A. A. , Drobakha V. E. , Nurieva Ju. A. , Shestakov V. V. 
Published: March 2020

Introduction. Perimesencephalic subarachnoid hemorrhage (PMSAH) accounts for approximately half of all cases of non-aneurysmal hemorrhage, has a typical pattern on computed tomography (CT) of the brain, and favorable clinical course. Moreover, in the domestic literature there are no studies devoted to this problem.The purpose of the study: to study the frequency of occurrence, clinical and CT features of PMSAH in comparison with nonaneurismatic non-PMSAH according to the hospital register of the regional stroke center.Materials and methods. The data of 383 patients who underwent treatment with a diagnosis of spontaneous SAH in the regional stroke center of Perm Clinical Hospital №4 in 2014–2019 were analyzed. All patients underwent a standard examination, including CT of the brain and digital selective angiography (DSA). According to the pattern of SAH on CT, patients are divided into the groups PM-1 (isolated preptine), PM-2 (traditional) and PM-3 (diffuse). Evaluation of the long-term outcome was carried out using a telephone interview, as well as according to the regional electronic medical system.Results. Of 383 patients with SAH, aneurysms were identified in 350 patients (91,3%). Non-aneurysmal SAH was found in 20 patients (5,2%), in 8 patients (2,1%) − PMSAH. The age of patients averaged 48 years, women predominated. Intense headache in the onset of the disease was observed in the vast majority of patients. Nausea was significantly more often observed in patients with PMSAР (50%) compared with patients with non-PMSAР (8,3%). Loss of consciousness occurred in every fourth patient with PMSAР and only 8% of patients with non-PMSAH. The neurological status of the patients also did not differ and was characterized by a normal consciousness, meningeal syndrome (in 63% of patients with PMSAH) in the absence of focal symptoms. The level of neurological deficit according to NIHSS averaged 0 points, the severity of SAH on the Hunt-Hess scale averaged 2 points. At the time of completion of treatment, most patients did not have a neurological and functional deficit. According to CT, in 4 patients (50%), PM-2 was visualized, in 3 patients (38%) − PM-3, and in one patient − PM-1 (12%). On average, after 15 months, none of the treated patients developed repeated SAH, patients did not have functional limitations.Conclusions. This study for the first time made it possible to characterize the approximate frequency of occurrence, clinical and CT picture, as well as the long-term prognosis of PMSAH in a cohort of patients from a large regional stroke center in Russia.
The role of targeted synthetic drugs in the treatment of rheumatic diseases: focus on tofacitinib
Authors: Karateev D. E. , Luchikhina E. L. 
Published: March 2020

The treatment of immuno-inflammatory rheumatic diseases has advanced significantly in recent decades due to development of biological medications, which, however, are not without some weak points. They include immunogenicity, parenteral administration, and potentially insufficient stability of the composition of the drug. Great hopes are related to a relatively new class of targeted synthetic immunomodulatory drugs, currently represented in rheumatology by JAK kinase inhibitors (tofacitinib, baricitinib, upadacitinib) and phosphodiesterase 4 inhibitor (apremilast). The most actively developed group is JAK inhibitors that influence one of the most important signal pathway of immune system. This family includes 4 subtypes: JAK1, JAK2, JAK3 и tyrosine-kinase2 (TYK2). JAK-kinases selectively aggregate with cytoplasmic domains of different cytokine receptors, activation of which includes intracellular signal pathway JAK-STAT (Signal Transducer and Activator of Transcription). STAT proteins are responsible for transduction of the signals from more than 50 cytokines, hormones and growth factors that regulate key processes of survival, proliferation and differentiation of immune cells. The greatest practical experience achieved on tofacitinib. This medication approved inRussiafor several indications: rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis. Clinical trials of III phase of ORAL series in rheumatoid arthritis and OPAL series in psoriatic arthritis showed high efficacy of Tofacitinib in different clinical situations. In Russian strategic trial REMARKA after treatment with Tofacitinib very fast improvement of the signs of activity was observed, 68,8% patients achieved low disease activity or remission at 6th month of follow-up. Russian open multi-center observational study of Tofacitinib in 101 patients with rheumatoid arthritis and insufficient efficacy of basic and biologic drugs showed achievement of low disease activity or remission in 60% patients, as well as significant improvement of quality of life with a very low frequency of withdrawals due to adverse events (less than 2%).
Etoricoxib in the treatment of osteoarthritis
Authors: Anikin S. G. , Alekseeva L. I. 
Published: March 2020

Osteoarthritis (OA) is one of the most common diseases of the musculoskeletal system.The main symptoms of osteoarthritis are pain, stiffness, joint swelling. According to epidemiological studies, about one-third of the chronic moderate and severe pain is associated with OA. Currently, OA is considered as a multifactorial disease resulting from the interaction of various genetic, biological, mechanical, and metabolic factors. Inflammation plays a central role in development and progression of ОА. In patients with OA, histological studies of the synovial membrane detected signs of chronic inflammation. The level of some proinflammatory cytokines may increased and the level of anti-inflammatory cytokines may decreased in blood serum, synovial fluid and joint tissue. Also, adaptive immune cell responses are detected in the joint tissues in patients of OA. Due to its high effectiveness, non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in OA. Oral or local forms of NSAIDs are the drugs of choice in the initial stages of therapy in all guidelines. Etoricoxib is a selective inhibitor of cyclooxygenase 2 (COX-2) and is used for the treatment of OA and other rheumatic diseases. The article discusses the use of etoricoxib in patients with OA.
Toxicity Evaluation of the Subacute Diazinon in Aged Male Rats: Hematological Aspects
Authors: Samarghandian Saeed , Farkhondeh Tahereh , Yousefizadeh Shahnaz 
Published: March 2020

Background & Objective::
Age-dependent Organophosphates (OPs) toxicity is a controversial
topic. The present study was designed to investigate the effect of the sub-acute exposure to
diazinon (DZN), one of the main OPs insecticides, on the hematological alterations in adult and
aged male rats.

Methods:
For the aim of this approach, the adult and aged rats were administered with DZN (15 mg/kg,
orally) for 4 weeks. Then, the blood samples were collected from the retro-orbital sinus for measuring
red blood cell (RBC), hemoglobin (Hb), hematocrit (Hct), platelets (PLT), MCV (mean corpuscular
volume), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin (MCHC).

Results:
The obtained results indicated that DZN significantly decreased RBCs (4.93 ± 0.41), Htc
(28.12 ± 1.21), Hb (10.31 ± 0.36), MCHC (30.51 ± 2.04), MCV (62.86 ± 2.58), and PLT (265.6 ±
34.81) values in the adult and aged rats versus the age-matched control rats. Moreover, RBC, Hb,
and Htc levels decreased significantly in the aged rats versus adult rats. However, no significant
differences were observed between MCHC, MCV, and PLT levels in adult and aged rats. Moreover,
the MCH concentration did not change in any group. Additionally, DZN did not deteriorate the hematological
alterations in the aged rats versus adult rats.

Conclusion:
The present study showed that the toxicity of DZN is not associated with age. However,
more studies should be conducted to confirm this finding.
Comparison of Effect of Colloid Graphite Nano Particle on Properties of Fuel Ash-Green Cement Composite
Authors: Kırgız Mehmet Serkan 
Published: March 2020

Aims:
This current study aims at comparing the effect of colloid graphite nano particle on the properties of class C pulverized fuel ash-green cement composite (CPFA-GCC).

Background:
In view of major and minor oxides, the CPFA is a very valuable artificial pozzolanic material, which is generated by power plant that uses high-calorie charcoal in the manufacturing of electrical energy, for the cement industry. The CPFA is light-brown color and includes more than 10

Objective:
The purpose of study reported in this article compares new properties of the CPFA-CC modified by either the GNP or the CGNP to discuss assessment of effect difference between the GNP and the CGNP. It also concludes the effectiveness of GNP and colloid GNP on the development of optical atomic absorbance spectra, stiffness-time, and flow, apparent density, apparent porosity, and apparent fullness as well as early age compressive stress.

Method:
The effect of colloid graphite nano particle on properties of fuel ash-green cement composite was measured as standard tests method and literature analysis accepted

Result:
Characteristic result of the GNP and the CGNP provides the defining of certain effect as the stiffness accelerator, the apparent density, and the apparent fullness increaser, the flow and the apparent porosity reducer as well as compressive stress gainer for green cement based composite at early age.

Conclusion:
In view of positive characteristic of the GNP and of the CGNP, those could be used such engineering applications as the green construction building, the infrastructure renewal, the construction retrofit, and the construction reinforcement for dramatically extend service life, that has taken advantage of the maintenance cost.

Other:
As explained in this article, the CGNP is the most logical, productive and sustainable additive to be used in manufacturing of the class C pulverized fuel ash-green cement binder and composite for saving the future of pure cement, making infrastructure safer, extending service life, reducing maintenance cost and natural resource use.
Analysis of Strengthening Mechanisms Forming the Yield Strength in Hardox 450 Steel
Authors: Smirnov A. N. , Ababkov N. V. , Popova N. A. , Murav’ev V. V. , Knyaz’kov K. V. , Koneva N. A. 
Published: March 2020

Представлены результаты исследования механизмов упрочнения, формирующих предел текучести в стали Hardox 450 в зоне термического влияния.В последнее время в связи с увеличением добычи угля и применением современной мощной горнодобывающей техники необходимо применять новые материалы с высокими эксплуатационными характеристиками. К таким материалам относится сталь Hardox 450, из которой изготовлены многие детали и элементы оборудования для добычи угля открытым способом.Установлено и рассчитано, что основной и практически одинаковый вклад в формирование предела текучести стали Hardox 450, как в исходном состоянии, так и в зоне термического влияния сварки, вносят дальнодействующие поля напряжений и дислокации «леса» (до 325…385 МПа – исходное состояние, 325…405 МПа – зона термического влияния). Значительный вклад в упрочнение вносят частицы цементита. Наличие структурной прослойки, выявленной электронно-микроскопическими исследованиями в зоне термического влияния, подтверждено расчетом вкладов различных видов упрочнения: неполяризованными дислокациями «леса», внутренними дальнодействующими полями, некогерентными карбидами, твердорастворное, зернограничное, субструктурное, торможение дислокаций в кристаллической решетке; здесь сумма вкладов минимальна (850 МПа) и достигнута снижением доли зернограничного упрочнения и перераспределения цементитных частиц в фазах.В результате исследований структуры и расчетов установлено, что сталь Hardox 450 в исходном состоянии и в зоне термического влияния после рекомендованного режима сварки имеет микроструктуру, обладающую высокими эксплуатационными свойствами. Присутствие структурной прослойки незначительно снижает эксплуатационные характеристики в зоне термического влияния.
PEMBENTUK UNDANG-UNDANG DI INDONESIA MENURUT UUDNRI 1945 SERTA KEDUDUKAN DPD DALAM PELAKSANAAN FUNGSI LEGISLASI PASCA PUTUSAN MAHKAMAH KONSTITUSI
Authors: Reza Fahrul 
Published: March 2020

Abstrak: Artikel ini akan membahas tentang dua permasalahan utama: Pertama, siapa pembentuk undang-undang di Indonesisa menurut UUD 1945 pasca putusan Mahkamah Konstitusi? Kedua, bagaimanakah kedudukan DPD dalam pelaksanaan fungsi legislasi pasca putusan Mahkamah Konstitusi? Hasil dari penelitian ini menjelaskan bahwa siapa pembentuk undang-undang di Indonesia menurut UUD 1945 pasca putusan Mahkamah Konstitusi jelas sudah terjawab oleh UUD Tahun 1945 pasca amandemen. Artinya keberadaan DPD harus equal dengan DPR dalam hal program legislasi di Indonesia. Selanjutnya kedudukan DPD dalam pelaksanaan fungsi legislasi pasca putusan Mahkamah Konstitusi juga sudah terjawab oleh putusan Mahkamah Konstitusi bahwa kehadiran DPD menjadi pengimbang legislasi di Indonesia bahkan jangan lagi Presiden dan DPR sebagai pendulum pembentuk undang-undang namun institusi DPD harus mendapatkan perhatian bahkan Kementerian juga harus menstarakan kedudukan DPD dengan DPR dalam rapat-rapat mitra kerja. Abstract: This article will discuss two main issues: First, who is the legislator in Indonesia according to the 1945 Constitution after the decision of the Constitutional Court? Second, how is the position of the DPD in the implementation of the legislative function after the Constitutional Court's decision? The results of this study explain that who is the legislator in Indonesia according to the 1945 Constitution after the decision of the Constitutional Court has clearly been answered by the 1945 Constitution after the amendment. This means that the presence of the DPD must be equal to the DPR in terms of the legislative program in Indonesia. Furthermore, the position of the DPD in the implementation of the legislation function after the Constitutional Court's ruling has also been answered by the Constitutional Court's ruling that the presence of the DPD is a balancer of legislation in Indonesia and not even the President and the House of Representatives as pendulators of legislative formations but the DPD institution must get the attention of even the Ministry DPD and the DPR in work partner meetings.
KAJIAN PENERAPAN DESAIN UNIVERSAL PADA RUANG KULIAH BAGI DISABILITAS PENDENGARAN DI PERGURUAN TINGGI (Studi kasus : Ruang Kuliah Gedung CADL di ITB)
Authors: Harahap Rachmita Maun , Santosa Imam , Wahjudi Deddy , Martokusumo Widjaja 
Published: March 2020

Hambatan arsitektural bagi disabilitas pendengaran terhadap desain universal yang diaplikasikan dalam kebutuhan jauh lebih jelas dan biasanya melibatkan informasi. Padahal disabilitas pendengaran memiliki kebutuhan ruang yang bersifat lebih spesifik. Penelitian bertujuan berusaha untuk memperbaiki konsep desain asli dengan membuat perguruan tinggi lebih universal dan mengintegrasikan penerapan desain universal dengan desain Deaf Space di ruang kuliah. Ruang kuliah berfungsi sebagai tempat kegiatan belajar mengajar bagi mahasiswa disabilitas pendengaran dan strategi untuk mengatasinya. Studi kasus di ruang kuliah gedung CADL di ITB, kemudian dilakukan eksperimen simulasi ruang kuliah bagi responden mahasiswa aktif/alumni/drop out disabilitas pendengaran dan informan kunci yang memahami regulasi desain universal. Guna memecahkan masalah tersebut, mendesain sebuah konsepsi desain Deaf Space kemudian dijelaskan penerapan konsep desain universal yang terkait aspek elemen interior. Metode penelitian adalah kualitatif deskriptif dan metode survei dengan teknik wawancara untuk mendapatkan data kebutuhan dari subjek penelitian. Penelitian juga bersifat evaluatif, yaitu menganalisis aspek elemen interior, yaitu area sirkulasi, tata letak furnitur, pencahayaan, warna dan akustik. Hasil penelitian menunjukkan aspe elemen interior tersebut di ruang kuliah belum memenuhi standar desain universal dan desain Deaf Space
ANALISIS VISUAL KARAKTER UTAMA DAN SISTEM KETERBACAAN PADA BUKU INFOGRAFIS STATIS SEBAGAI SARANA EDUKASI BAGI ANAK SEKOLAH DASAR (SD)
Authors: Hasni Fatimah Yasmin , Yustikasari Nur Afni 
Published: March 2020

Infografis merupakan desain visual yang menggabungkan visualisasi data, ilustrasi, teks dan gambar dalam satu kesatuan dan membentuk sebuah cerita. Saat ini, infografis menjadi media informasi yang diminati, karena visual yang sederhana sehingga mudahan dipahami. Infografis menjadi pilihan baru untuk menyampaikan informasi, penggabungan penyampaian pembelajaran dan menghindari pembacaan juga tata letak yang menjenuhkan dengan visualisasi yang menyegarkan akan membantu anak menerima informasi/pembelajaran lebih baik daripada tulisan yang terkesan panjang.Pada penelitian kali ini peneliti meninjau buku infografis anak “Yuk, Mengenal 5 Rukun Islam!”. Pembuatan konsep menentukan keberhasilan infografis dalam fungsinya yaitu menyampaikan data secara informatif. Peneliti juga meninjau tampilan visual yang berkaitan terhadap karakter, warna, bentuk berupa bidang, ilustrasi, tipografi, ikon/simbol, dan layout yang digunakan. Berdasarkan data tersebut, penelitian ini akan mengkaji buku infografis berjudul “Yuk, Mengenal 5 Rukun Islam!”, buku ini menjadi salah satu buku edukasi anak yang beredar di beberapa toko buku dengan mencantumkan “Infografis” dalam sampul bukunya. Dengan meneliti bagaimana infografis tepat untuk edukasi anak, diharapkan akan menjadi strategi baru dalam proses belajar mengajar demi menumbuhkan semangat belajar siswa.