bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic associations between interpersonal needs and suicidal ideation in a sample of individuals with eating disorders
Authors: Bodell Lindsay P. , Smith April R. , Witte Tracy K. 
Published: March 2020

AbstractBackgroundOver half of individuals with eating disorders experience suicidal ideation at some point in their lives, yet few longitudinal studies have examined predictors of ideation in this at-risk group. Moreover, prospective research has focused on relatively distal or trait-level factors that are informative for distinguishing who is most at risk but not when. Little is known about more proximal or state-level risk factors that fluctuate within an individual, which is critical for determining when a person is most likely to engage in suicidal behaviors.MethodsWomen (N= 97) receiving treatment for their eating disorder completed questionnaires weekly to assess suicidal ideation and interpersonal constructs (i.e. perceived burdensomeness, thwarted belongingness) theorized to be proximal predictors of suicidal desire. Longitudinal multilevel models were conducted to examine both within- and between-person predictors of suicidal ideation across 12 weeks of treatment.ResultsStatistically significant within-person effects for burdensomeness (β= 0.06;p< 0.001) indicate that when individuals have greater feelings of burdensomeness compared to their own average, they also experience higher suicidal ideation. We did not find any significant influence of thwarted belongingness or the interaction between burdensomeness and belongingness on suicidal ideation.ConclusionsThis study was the first to examine dynamic associations between interpersonal constructs and suicidal ideation in individuals with eating disorders. Results are only partially consistent with the Interpersonal Theory of Suicide and suggest that short-term changes in burdensomeness may impact suicidal behavior in individuals with eating disorders.
FEMINISTING FREE IMPROVISATION
Authors: Reardon-Smith Hannah , Denson Louise , Tomlinson Vanessa 
Published: March 2020

AbstractThe idea and meaning of ‘freedom’ in free improvisation has largely been determined by a masculine subject position. This paper proposes a thinking of free improvisation from a feminist perspective, drawing upon the writings of Donna Haraway, Sara Ahmed and Anna Löwenhaupt Tsing, and on our own practices as improvising musicians. Reflecting on our own experiences in music and life, we ask: What does it mean to be a feminist free improviser? What inspires us to seek freedom through our improvisation practices? Can thinking improvisation through the lens of feminist theory inform our improvisational practices? We seek to think improvisation from a collective, inclusive origin. We posit that improvising is always, as Donna Haraway has suggested, ‘making-with’: creating, moment-to-moment, requiring interaction with the environment and its inhabitants. Free improvisation is not free if its practice is delimited by an exclusive world view. ‘Feministing’ free improvisation can challenge assumptions that undermine free improvisation's claim to freedom.
Reduced diet breadth in the Scarlet MacawAra macaoof the Área de Conservación Osa (ACOSA), Costa Rica: Implications for conservation and ecotourism
Authors: HAMM JOSEPH O.E. , BOND GRACE M. , EXLEY LAURA C. , KOREIN EMMA A. 
Published: March 2020

SummaryThe Área de Conservación Osa (ACOSA) contains the largest population of Scarlet MacawsAra macaoin Costa Rica. Despite their influence on ecosystem dynamics and status as a flagship species, empirical data on the foraging patterns of this population is lacking. This information is crucial in implementing effective conservation strategies, particularly reintroduction attempts. Observations of feeding behaviour were made systematically over a 12-month period to provide the first direct examination of Scarlet Macaw diet within the ACOSA region. Scarlet Macaws feed on various items including seeds, flowers, bark, and leaf-gall larvae. Key findings included a demonstration of a smaller dietary niche breadth than that recorded for other Central American populations, use of button mangroveConocarpus erectus, a species not previously recognised as a food source for Scarlet Macaws, and a heavy reliance on an exotic non-native species,Terminalia catappa.We argue that whilst human-modified coastal locations may present viable habitat for Scarlet Macaws, anthropogenic influences including the removal of native food sources and proliferation of exotic and cultivated species have left the Scarlet Macaws of the ACOSA particularly dependent on a small number of species.
Oxygen Vacancy Substitution Linked to Ferric Iron in Bridgmanite at 27 GPa
Authors: Fei Hongzhan , Liu Zhaodong , McCammon Catherine , Katsura Tomoo 
Published: March 2020

AbstractFerric iron can be incorporated into the crystal structure of bridgmanite by either oxygen vacancy substitution (MgFeO2.5 component) or charge‐coupled substitution (FeFeO3 component) mechanisms. We investigated the concentrations of MgFeO2.5 and FeFeO3 in bridgmanite in the MgO‐SiO2‐Fe2O3 system at 27 GPa and 1700–2300 K using a multianvil apparatus. The FeFeO3 content increases from 1.6 to 7.6 mol.% and from 5.7 to 17.9 mol.% with and without coexistence of (Mg,Fe)O, respectively, with increasing temperature from 1700 to 2300 K. In contrast, the MgFeO2.5 content does not show clear temperature dependence, that is, ~2–3 and < 2 mol.% with and without the coexistence of (Mg,Fe)O, respectively. Therefore, the presence of (Mg,Fe)O enhances the oxygen vacancy substitution for Fe3+ in bridgmanite. It is predicted that Fe3+ is predominantly substituted following the oxygen vacancy mechanism in (Mg,Fe)O‐saturated Al‐free bridgmanite when Fe3+ is below ~0.025 pfu, whereas the charge‐coupled mechanism occurs when Fe3+ > 0.025 pfu.
On the Ubiquity of Magnetic Reconnection Inside Flux Transfer Event‐Like Structures at the Earth's Magnetopause
Authors: Fargette N. , Lavraud B. , Øieroset M. , Phan T. D. , Toledo‐Redondo S. , Kieokaew R. , Jacquey C. , Fuselier S. A. , Trattner K. J. , Petrinec S. , Hasegawa H. , Garnier P. , Génot V. , Lenouvel Q. , Fadanelli S. , Penou E. , Sauvaud J.‐A. , Avanov D. L. A. , Burch J. , Chandler M. O. , Coffey V. N. , Dorelli J. , Eastwood J. P. , Farrugia C. J. , Gershman D. J. , Giles B. L. , Grigorenko E. , Moore T. E. , Paterson W. R. , Pollock C. , Saito Y. , Schiff C. , Smith S. E. 
Published: March 2020

AbstractFlux transfer events (FTEs) are transient phenomena frequently observed at the Earth's magnetopause. Their usual interpretation is a flux rope moving away from the reconnection region. However, the Magnetospheric Multiscale Mission revealed that magnetic reconnection sometimes occurs inside these structures, questioning their flux rope configuration. Here we investigate 229 FTE‐type structures and find reconnection signatures inside 19% of them. We analyze their large‐scale magnetic topology using electron heat flux and find that it is significantly different across the FTE reconnecting current sheets, demonstrating that they are constituted of two magnetically disconnected structures. We also find that the interplanetary magnetic field (IMF) associated with reconnecting FTEs presents a strong By component. We discuss several formation mechanisms to explain these observations. In particular, the maximum magnetic shear model predicts that for large IMF By, two spatially distinct X lines coexist at the magnetopause. They can generate separate magnetic flux tubes that may become interlaced.
Polyphase Tectonic Evolution of Fore‐Arc Basin Related to STEP Fault as Revealed by Seismic Reflection Data From the Alboran Sea (W‐Mediterranean)
Authors: d'Acremont E. , Lafosse M. , Rabaute A. , Teurquety G. , Do Couto D. , Ercilla G. , Juan C. , de Lépinay B. Mercier , Lafuerza S. , Galindo‐Zaldivar J. , Estrada F. , Vazquez J. T. , Leroy S. , Poort J. , Ammar A. , Gorini C. 
Published: March 2020

AbstractSince the Miocene, the thinned continental crust below the Alboran Sea and its overlying sedimentary cover have been undergoing deformation caused by both convergence of Eurasia and Africa and by deep processes related to the Tethyan slab retreat. Part of this deformation is recorded at the Xauen and Tofiño banks in the southern Alboran Sea. Using swath bathymetry and multichannel seismic reflection data, we identified different stages and styles of deformation. The South Alboran Basin is made up of Early Miocene to Pliocene sedimentary layers that correlate with the West Alboran Basin depocenter and are dominated by E‐W trending folds and thrusts. The Xauen and Tofiño Banks first recorded the phase of extension and strike‐slip movement during the slab retreat, followed by the phase of compressional inversion since the Tortonian and are now structured by tight folds, thrusts, and mud bodies. This study proposes that the Banks were located on the southern‐inherited Subduction Tear Edge Propagator (STEP) fault related to the westward migration of the Alboran domain during the Miocene. The STEP fault zone, acting as a boundary between the African block and the Alboran block, was located along the onshore Jebha‐Nekor fault and the offshore Alboran Ridge and the Yusuf fault zone. Thick‐skinned and thin‐skinned shortening occurred when slab retreat stopped, and inversion began. The present‐day style of the deformation seems to be linked to a decollement level made of undercompacted shale on top of the Ghomaride complex.
Bortezomib-based consolidation or maintenance therapy for multiple myeloma: a meta-analysis
Authors: Zhang Shijia , Kulkarni Amit A. , Xu Beibei , Chu Haitao , Kourelis Taxiarchis , Go Ronald S. , Wang Michael L. , Bachanova Veronika , Wang Yucai 
Published: March 2020

AbstractBortezomib-based regimens are widely used as induction therapy for multiple myeloma (MM). Unlike lenalidomide, the role of bortezomib in consolidation and maintenance therapy for MM is less clear. We performed a meta-analysis to evaluate the impact of bortezomib-based consolidation and maintenance therapy on survival outcomes and adverse events. PubMed, Web of Science, Embase databases, and major conference proceedings were searched for randomized controlled trials (RCTs) of bortezomib-based regimens as consolidation or maintenance therapy for MM. Ten RCTs enrolling 3147 patients were included in the meta-analysis. Bortezomib-based regimens were compared with regimens without bortezomib or observation. The meta-analysis suggested that bortezomib-based maintenance therapy improved progression-free survival (PFS; hazard ratio [HR] = 0.72, 95% CI 0.55–0.95, P = 0.02) and overall survival (OS; HR = 0.71, 95% CI 0.58–0.87, P = 0.001). Bortezomib-based consolidation therapy improved PFS (HR = 0.77, 95% CI 0.68–0.88, P < 0.001) but not OS (HR = 0.98, 95% CI 0.78–1.24, P = 0.87). Bortezomib-based consolidation/maintenance therapy led to a trend toward increased risk of grade ≥ 3 neurologic symptoms, gastrointestinal symptoms, and fatigue. More research is warranted to further assess the role of bortezomib-based consolidation and maintenance therapy for multiple myeloma.
Deep learning radiomics can predict axillary lymph node status in early-stage breast cancer
Authors: Zheng Xueyi , Yao Zhao , Huang Yini , Yu Yanyan , Wang Yun , Liu Yubo , Mao Rushuang , Li Fei , Xiao Yang , Wang Yuanyuan , Hu Yixin , Yu Jinhua , Zhou Jianhua 
Published: March 2020

AbstractAccurate identification of axillary lymph node (ALN) involvement in patients with early-stage breast cancer is important for determining appropriate axillary treatment options and therefore avoiding unnecessary axillary surgery and complications. Here, we report deep learning radiomics (DLR) of conventional ultrasound and shear wave elastography of breast cancer for predicting ALN status preoperatively in patients with early-stage breast cancer. Clinical parameter combined DLR yields the best diagnostic performance in predicting ALN status between disease-free axilla and any axillary metastasis with areas under the receiver operating characteristic curve (AUC) of 0.902 (95% confidence interval [CI]: 0.843, 0.961) in the test cohort. This clinical parameter combined DLR can also discriminate between low and heavy metastatic burden of axillary disease with AUC of 0.905 (95% CI: 0.814, 0.996) in the test cohort. Our study offers a noninvasive imaging biomarker to predict the metastatic extent of ALN for patients with early-stage breast cancer.
Single particles as resonators for thermomechanical analysis
Authors: Okeyo Peter Ouma , Larsen Peter Emil , Kissi Eric Ofosu , Ajalloueian Fatemeh , Rades Thomas , Rantanen Jukka , Boisen Anja 
Published: March 2020

AbstractThermal methods are indispensable for the characterization of most materials. However, the existing methods require bulk amounts for analysis and give an averaged response of a material. This can be especially challenging in a biomedical setting, where only very limited amounts of material are initially available. Nano- and microelectromechanical systems (NEMS/MEMS) offer the possibility of conducting thermal analysis on small amounts of materials in the nano-microgram range, but cleanroom fabricated resonators are required. Here, we report the use of single drug and collagen particles as micro mechanical resonators, thereby eliminating the need for cleanroom fabrication. Furthermore, the proposed method reveals additional thermal transitions that are undetected by standard thermal methods and provide the possibility of understanding fundamental changes in the mechanical properties of the materials during thermal cycling. This method is applicable to a variety of different materials and opens the door to fundamental mechanistic insights.
CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling
Authors: Jun Joon-Il , Lau Lester F. 
Published: March 2020

AbstractExpression of the matricellular protein CCN1 (CYR61) is associated with inflammation and is required for successful wound repair. Here, we show that CCN1 binds bacterial pathogen-associated molecular patterns including peptidoglycans of Gram-positive bacteria and lipopolysaccharides of Gram-negative bacteria. CCN1 opsonizes methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa and accelerates their removal by phagocytosis and increased production of bactericidal reactive oxygen species in macrophages through the engagement of integrin αvβ3. Mice with myeloid-specific Ccn1 deletion and knock-in mice expressing CCN1 unable to bind αvβ3 are more susceptible to infection by S. aureus or P. aeruginosa, resulting in increased mortality and organ colonization. Furthermore, CCN1 binds directly to TLR2 and TLR4 to activate MyD88-dependent signaling, cytokine expression and neutrophil mobilization. CCN1 is therefore a pattern recognition receptor that opsonizes bacteria for clearance and functions as a damage-associated molecular pattern to activate inflammatory responses, activities that contribute to wound healing and tissue repair.
Collapse of layer dimerization in the photo-induced hidden state of 1T-TaS2
Authors: Stahl Quirin , Kusch Maximilian , Heinsch Florian , Garbarino Gaston , Kretzschmar Norman , Hanff Kerstin , Rossnagel Kai , Geck Jochen , Ritschel Tobias 
Published: March 2020

AbstractPhoto-induced switching between collective quantum states of matter is a fascinating rising field with exciting opportunities for novel technologies. Presently, very intensively studied examples in this regard are nanometer-thick single crystals of the layered material 1T-TaS2, where picosecond laser pulses can trigger a fully reversible insulator-to-metal transition (IMT). This IMT is believed to be connected to the switching between metastable collective quantum states, but the microscopic nature of this so-called hidden quantum state remained largely elusive up to now. Here, we characterize the hidden quantum state of 1T-TaS2 by means of state-of-the-art x-ray diffraction and show that the laser-driven IMT involves a marked rearrangement of the charge and orbital order in the direction perpendicular to the TaS2-layers. More specifically, we identify the collapse of interlayer molecular orbital dimers as a key mechanism for this non-thermal collective transition between two truly long-range ordered electronic crystals.
Controlled partial transfer hydrogenation of quinolines by cobalt-amido cooperative catalysis
Authors: Pang Maofu , Chen Jia-Yi , Zhang Shengjie , Liao Rong-Zhen , Tung Chen-Ho , Wang Wenguang 
Published: March 2020

AbstractCatalytic hydrogenation or transfer hydrogenation of quinolines was thought to be a direct strategy to access dihydroquinolines. However, the challenge is to control the chemoselectivity and regioselectivity. Here we report an efficient partial transfer hydrogenation system operated by a cobalt-amido cooperative catalyst, which converts quinolines to 1,2-dihydroquinolines by the reaction with H3N·BH3 at room temperature. This methodology enables the large scale synthesis of many 1,2-dihydroquinolines with a broad range of functional groups. Mechanistic studies demonstrate that the reduction of quinoline is controlled precisely by cobalt-amido cooperation to operate dihydrogen transfer from H3N·BH3 to the N=C bond of the substrates.
Verifying molecular clusters by 2-color localization microscopy and significance testing
Authors: Arnold Andreas M. , Schneider Magdalena C. , Hüsson Christoph , Sablatnig Robert , Brameshuber Mario , Baumgart Florian , Schütz Gerhard J. 
Published: March 2020

AbstractWhile single-molecule localization microscopy (SMLM) offers the invaluable prospect to visualize cellular structures below the diffraction limit of light microscopy, its potential has not yet been fully capitalized due to its inherent susceptibility to blinking artifacts. Particularly, overcounting of single molecule localizations has impeded a reliable and sensitive detection of biomolecular nanoclusters. Here we introduce a 2-Color Localization microscopy And Significance Testing Approach (2-CLASTA), providing a parameter-free statistical framework for the qualitative analysis of two-dimensional SMLM data via significance testing methods. 2-CLASTA yields p-values for the null hypothesis of random biomolecular distributions, independent of the blinking behavior of the chosen fluorescent labels. The method is parameter-free and does not require any additional measurements nor grouping of localizations. We validated the method both by computer simulations as well as experimentally, using protein concatemers as a mimicry of biomolecular clustering. As the new approach is not affected by overcounting artifacts, it is able to detect biomolecular clustering of various shapes at high sensitivity down to a level of dimers.
Using global isotopic data to constrain the role of shale gas production in recent increases in atmospheric methane
Authors: Milkov Alexei V. , Schwietzke Stefan , Allen Grant , Sherwood Owen A. , Etiope Giuseppe 
Published: March 2020

AbstractThe accelerated increase in global methane (CH4) in the atmosphere, accompanied by a decrease in its 13C/12C isotopic ratio (δ13CCH4) from −47.1‰ to −47.3‰ observed since 2008, has been attributed to increased emissions from wetlands and cattle, as well as from shale gas and shale oil developments. To date both explanations have relied on poorly constrained δ13CCH4 source signatures. We use a dataset of δ13CCH4 from >1600 produced shale gas samples from regions that account for >97% of global shale gas production to constrain the contribution of shale gas emissions to observed atmospheric increases in the global methane burden. We find that US shale gas extracted since 2008 has volume-weighted-average δ13CCH4 of −39.6‰. The average δ13CCH4 weighted by US basin-level measured emissions in 2015 was −41.8‰. Therefore, emission increases from shale gas would contribute to an opposite atmospheric δ13CCH4 signal in the observed decrease since 2008 (while noting that the global isotopic trend is the net of all dynamic source and sink processes). This observation strongly suggests that changing emissions of other (isotopically-lighter) CH4 source terms is dominating the increase in global CH4 emissions. Although production of shale gas has increased rapidly since 2008, and CH4 emissions associated with this increased production are expected to have increased overall in that timeframe, the simultaneously-observed increase in global atmospheric CH4 is not dominated by emissions from shale gas and shale oil developments.
Evaluation of Radiation dosimetry of 99mTc-HYNIC-PSMA and imaging in prostate cancer
Authors: Zhang Jianping , Zhang Jiangang , Xu Xiaoping , Lu Linjun , Hu Silong , Liu Chang , Cheng Jingyi , Song Shaoli , Zhang Yingjian , Shi L. Q. 
Published: March 2020

AbstractThis study aims to evaluate the radiation dosimetry of a new technetium-99m‒labelled small-molecule inhibitor of prostate-specific membrane antigen (HYNIC-Glu-Urea-A, 99mTc-HYNIC-PSMA) and its feasibility as a tumor-imaging agent in prostate cancer (PCa) patients. A total of 15 PCa patients were enrolled in this study. For the dosimetry study, 5 PCa patients received whole-body planar scans at 0.5 h, 1 h, 2 h, 4 h and 8 h after 99mTc-HYNIC-PSMA injection. The Dosimetry Toolkit (GE, Milwaukee) was used to process the data and segment the organs in the SPECT/CT images, which were then projected onto planar images. The organ-specific absorbed doses, total-body absorbed doses and 99mTc-HYNIC-PSMA effective doses of patients were calculated using OLINDA/EXM 1.1 software. Whole-body SPECT/CT images were also acquired from additional 10 prostate patients to investigate the feasibility of 99mTc-HYNIC-PSMA for imaging tumors by calculating the ratio of tumor-to-background tracer uptake at 2 h after 740 MBq administration. The total-body absorbed dose was 1.54E-03 ± 2.43E-04 mGy/MBq, and the effective dose was 3.72E-03 ± 4.5E-04 mSv/MBq. Compared to published studies of other similar PSMA tracers and 99mTc-targeted conventional tracers, the absorbed doses of 99mTc-HYNIC-PSMA in all organs showed that it could be used safely in the human body. In addition, 99mTc-HYNIC-PSMA showed high tracer uptake (with a tumor-to-background ratio of 9.42 ± 2.62) in the malignant lesions of PCa patients, making it a promising radiopharmaceutical imaging method for site-specific management of PCa.