bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth to early adulthood following extremely preterm birth: the EPICure study
Authors: Ni Yanyan , Beckmann Joanne , Gandhi Rashmi , Hurst John R , Morris Joan K , Marlow Neil 
Published: January 2020

ObjectiveTo investigate growth trajectories from age 2.5 to 19 years in individuals born before 26 weeks of gestation (extremely preterm; EP) compared with term-born controls.MethodsMultilevel modelling of growth data from the EPICure study, a prospective 1995 birth cohort of 315 EP participants born in the UK and Ireland and 160 term-born controls recruited at school age. Height, weight, head circumference and body mass index (BMI) z-scores were derived from UK standards at ages 2.5, 6, 11 and 19 years.Results129 (42%) EP children were assessed at 19 years. EP individuals were on average 4.0 cm shorter and 6.8 kg lighter with a 1.5 cm smaller head circumference relative to controls at 19 years. Relative to controls, EP participants grew faster in weight by 0.06 SD per year (95% CI 0.05 to 0.07), in head circumference by 0.04 SD (95% CI 0.03 to 0.05), but with no catch-up in height. For the EP group, because of weight catch-up between 6 and 19 years, BMI was significantly elevated at 19 years to +0.32 SD; 23.4% had BMI >25 kg/m2and 6.3% >30 kg/m2but these proportions were similar to those in control subjects. EP and control participants showed similar pubertal development in early adolescence, which was not associated with height at 19 years in either study group. Growth through childhood was related to birth characteristics and to neonatal feeding practices.ConclusionsEP participants remained shorter and lighter and had smaller head circumferences than reference data or controls in adulthood but had elevated BMI.
The epidemiology of hepatitis delta virus infection in Cameroon
Authors: Besombes Camille , Njouom Richard , Paireau Juliette , Lachenal Guillaume , Texier Gaëtan , Tejiokem Mathurin , Cauchemez Simon , Pépin Jacques , Fontanet Arnaud 
Published: January 2020

ObjectiveTo investigate the distribution and risk factors of hepatitis delta virus (HDV) infection in Cameroon.DesignWe tested for hepatitis B virus (HBV) surface antigen (HBsAg) and anti-HDV antibody 14 150 samples collected during a survey whose participants were representative of the Cameroonian adult population. The samples had already been tested for hepatitis C virus and HIV antibodies.ResultsOverall, 1621/14 150 (weighted prevalence=11.9%) participants were HBsAg positive, among whom 224/1621 (10.6%) were anti-HDV positive. In 2011, the estimated numbers of HBsAg positive and HDV seropositives were 1 160 799 and 122 910 in the 15–49 years age group, respectively. There were substantial regional variations in prevalence of chronic HBV infection, but even more so for HDV (from 1% to 54%). In multivariable analysis, HDV seropositivity was independently associated with living with an HDV-seropositive person (OR=8.80; 95% CI: 3.23 to 24.0), being HIV infected (OR=2.82; 95% CI: 1.32 to 6.02) and living in the South (latitude <4°N) while having rural/outdoor work (OR=15.2; 95% CI: 8.35 to 27.6, when compared with living on latitude ≥4°N and not having rural/outdoor work).ConclusionWe found evidence for effective intra-household transmission of HDV in Cameroon. We also identified large differences in prevalence between regions, with cases concentrated in forested areas close to the Equator, as described in other tropical areas. The reasons underlying these geographical variations in HDV prevalence deserve further investigation.
Pulmonary embolism rule out: positivity and factors affecting the yield of CT angiography
Authors: Aggarwal Tanya , Eskandari Ali , Priya Sarv , Mullan Aidan , Garg Ishan , Siembida Jakub , Mullan Brian , Nagpal Prashant 
Published: January 2020

AbstractObjectiveCT pulmonary angiography (CTPA) is one of the most commonly ordered CT imaging tests. It is often believed to be overutilised with few recent studies showing a yield of less than 2%. This study aimed to determine the overall positivity rate of CTPA examinations and understand the factors that affect the yield of the CTPA examination.MethodsWe retrospectively analysed 2713 patients who received the CTPA exam between 2016 and 2018. Type of study ordered (CTPA chest or CTPA chest with abdomen and pelvis CT), patient location (emergency department (ED), outpatient, inpatient, intensive care unit (ICU)) and patient characteristics—age, sex and body mass index (BMI) were recorded. A logistic regression analysis was performed to determine what factors affect the positivity rate of CT scans for pulmonary embolism (PE).ResultsWith 296 positive test results, the overall CTPA positivity was 10.9%. Male sex was associated with higher CTPA positivity, gender difference was maximum in 18-year to 35-year age group. Overweight and obese patients had significantly higher positivity as compared with BMI&lt;25 (p&lt;0.05). Higher positivity rate was seen in the BMI 25–40 group (11.9%) as compared with BMI&gt;40 (10.1%) (p&lt;0.05). Significant difference (p&lt;0.001) was also found in CTPA examination yield from ICU (15.3%) versus inpatients (other than ICU) (12.4%) versus ED (9.6%), and outpatients (8.5%). The difference in CTPA yield based on the type of CT order (CTPA chest vs CTPA chest with CT abdomen and pelvis), patient’s age and sex was not significant.ConclusionCTPA yield of 10.9% in this study is comparable to acceptable positivity rate for the USA and is higher than recent studies showing positivity of &lt;2%. Patient characteristics like obesity and ICU or inpatient location are associated with higher rate of CT positivity.
Anti-ulcerogenic activity of Gum Arabic in gastric mucosal injury induced by ethanol in male albino rats
Authors: Taha Mervat S. , El-Sherbiny Emad. M. , Osman Hala. F. 
Published: January 2020

The present study was performed to evaluate the anti-ulcerogenic activity of Acacia senegal (Gum Arabic) against ethanol-induced gastric mucosal injury in rats. Thirty-six adult male albino rats were divided into 4 groups: group 1 served as a control; group 2 consisted of rats that received 15% of gum in drinking water for 2 weeks; group 3 comprised ulcerated animals administered 5 mL of ethanol/kg body weight by gavage; and group 4 consisted of rats received 15% of gum in drinking water for 2 weeks before ethanol administration. Superoxide dismutase (SOD) glutathione peroxidase (GPx), malondialdehyde (MDA), prostaglandin E2(PGE2), tumor necrosis factor alpha (TNF-α), interleukin (IL)-B1), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein, and albumin were assayed in addition to histological study. The results revealed that ethanol decreased SOD, GPx, and PGE2in tissue and serum total protein and albumin, while increased MDA in tissue, serum TNF-α, IL-B1, PGE2, ALT, AST, and ALP. Histological findings showed less edema and leucocytes infiltration compared with ulcer group. Furthermore, gum administration elevated PGE2, SOD, and GPx and significantly reduced MDA, TNF-α, and IL-B2. In conclusion, Gum Arabic can enhance gastric protection and sustain the integrity of the gastric mucosa.Novelty The selected dose of Gum Arabic has the ability to decrease the pro-inflammatory cytokines in plasma and gastric tissue, thus enhancing gastric protection and maintaining the integrity of the gastric mucosa. Gum Arabic can compensate for the loss of antioxidants.
Solid-state tube wakefield accelerator using surface waves in crystals
Authors: Sahai Aakash A. , Tajima Toshiki , Taborek Peter , Shiltsev Vladimir D. 
Published: January 2020

Solid-state or crystal acceleration has for long been regarded as an attractive frontier in advanced particle acceleration. However, experimental investigations of solid-state acceleration mechanisms which offer [Formula: see text] acceleration gradients have been hampered by several technological constraints. The primary constraint has been the unavailability of attosecond particle or photon sources suitable for excitation of collective modes in bulk crystals. Secondly, there are significant difficulties with direct high-intensity irradiation of bulk solids, such as beam instabilities due to crystal imperfections and collisions etc. Recent advances in ultrafast technology with the advent of submicron long electron bunches and thin-film compressed attosecond x-ray pulses have now made accessible ultrafast sources that are nearly the same order of magnitude in dimensions and energy density as the scales of collective electron oscillations in crystals. Moreover, nanotechnology enabled growth of crystal tube structures not only mitigates the direct high-intensity irradiation of materials, with the most intense part of the ultrafast source propagating within the tube but also enables a high degree of control over the crystal properties. In this work, we model an experimentally practicable solid-state acceleration mechanism using collective electron oscillations in crystals that sustain propagating surface waves. These surface waves are driven in the wake of a submicron long particle beam, ideally also of submicron transverse dimensions, in tube shaped nanostructured crystals with tube wall densities, [Formula: see text]. Particle-In-Cell (PIC) simulations carried out under experimental constraints demonstrate the possibility of accessing average acceleration gradients of several [Formula: see text] using the solid-state tube wakefield acceleration regime. Furthermore, our modeling demonstrates the possibility that as the surface oscillations and resultantly the surface wave transitions into a nonlinear or “crunch-in” regime under [Formula: see text], not only does the average gradient increase but strong transverse focusing fields extend down to the tube axis. This work thus demonstrates the near-term experimental realizability of Solid-State Tube Wakefield Accelerator (SOTWA). The ongoing progress in nanoengineering and attosecond source technology thereby now offers the potential to experimentally realize the promise of solid-state or crystal acceleration, opening up unprecedented pathways in miniaturization of accelerators.
Addition of trans fat and alcohol has divergent effects on atherogenic diet-induced liver injury in rodent models of steatohepatitis
Authors: Daniels Samuel J. , Leeming Diana J. , Detlefsen Sönke , Bruun Maria F. , Hjuler Sara T. , Henriksen Kim , Hein Peter , Krag Aleksander , Karsdal Morten A. , Nielsen Mette Juul , Brockbank Sarah , Cruwys Simon 
Published: January 2020

Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are common causes of chronic liver disease. The overlap between ALD and NAFLD suggests the existence of metabolic steatohepatitis. Development of in vivo models that reflect various aspects of human steatohepatitis is essential for drug discovery. We aimed to characterize several models of steatohepatitis (SH) and to investigate whether the pathology could be modulated. Sprague-Dawley rats were fed a high-fat diet (HFD) for 9 wk, followed by either a high-fat, high-cholesterol and cholate diet (HFC) or a HFC diet containing 13% trans fat (HFC-TF). A subset received 15% ethanol-water twice a week for 12 wk. Serum triglycerides, cholesterol, LDL, HDL, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and rodent NH2-terminal propeptide of type III collagen (rPRO-C3) were assessed. The liver was weighed and evaluated using modified Nonalcoholic Steatohepatitis Clinical Research Network histological score system criteria. All diets induced hepatomegaly, but only HFC-TF increased the size of visceral adipose tissue. Trans fat augmented HFC-induced dyslipidemia, and cholesterol was higher and HDL was lower in the HFC-TF groups. Alcohol lowered triglycerides in both dietary groups. HFC elevated ALT and AST, which were lowered by trans fat. All diets induced histological SH, addition of trans fat induced more steatosis but less inflammation. Inclusion of alcohol augmented the HFC-induced inflammation. All diets induced mild fibrosis. Inclusion of trans fat and alcohol significantly increased rPRO-C3. The addition of trans fat reduced the HFC-induced inflammation but augmented steatosis and dyslipidemia. Inclusion of alcohol induced a more inflammatory and fibrogenic phenotype. NEW & NOTEWORTHY Alcoholic liver disease and nonalcoholic liver disease share significant overlap, which suggests the existence of metabolic steatohepatitis. Trans fat has been implicated in steatohepatitis development. Here, we show that the addition of trans fat to an atherogenic diet results in a more steatotic but less inflammatory phenotype, whereas the addition of alcohol to an atherogenic diet augments the inflammatory and fibrogenic properties of the diet.
Mechanisms underlying reduced weight gain in intestinal fatty acid-binding protein (IFABP) null mice
Authors: Lackey Atreju I. , Chen Tina , Zhou Yin X. , Bottasso Arias Natalia M. , Doran Justine M. , Zacharisen Sophia M. , Gajda Angela M. , Jonsson William O. , Córsico Betina , Anthony Tracy G. , Joseph Laurie B. , Storch Judith 
Published: January 2020

Intestinal-fatty acid binding protein (IFABP; FABP2) is a 15-kDa intracellular protein abundantly present in the cytosol of the small intestinal (SI) enterocyte. High-fat (HF) feeding of IFABP−/−mice resulted in reduced weight gain and fat mass relative to wild-type (WT) mice. Here, we examined intestinal properties that may underlie the observed lean phenotype of high fat-fed IFABP−/−mice. No alterations in fecal lipid content were found, suggesting that the IFABP−/−mice are not malabsorbing dietary fat. However, the total excreted fecal mass, normalized to food intake, was increased for the IFABP−/−mice relative to WT mice. Moreover, intestinal transit time was more rapid in the IFABP−/−mice. IFABP−/−mice displayed a shortened average villus length, a thinner muscularis layer, reduced goblet cell density, and reduced Paneth cell abundance. The number of proliferating cells in the crypts of IFABP−/−mice did not differ from that of WT mice, suggesting that the blunt villi phenotype is not due to alterations in proliferation. IFABP−/−mice were observed to have altered expression of genes and proteins related to intestinal structure, while immunohistochemical analyses revealed increased staining for markers of inflammation. Taken together, these studies indicate that the ablation of IFABP, coupled with high-fat feeding, leads to changes in gut motility and morphology, which likely contribute to the relatively leaner phenotype occurring at the whole-body level. Thus, IFABP is likely involved in dietary lipid sensing and signaling, influencing intestinal motility, intestinal structure, and nutrient absorption, thereby impacting systemic energy metabolism.NEW & NOTEWORTHY Intestinal fatty acid binding protein (IFABP) is thought to be essential for the efficient uptake and trafficking of dietary fatty acids. In this study, we demonstrate that high-fat-fed IFABP−/−mice have an increased fecal output and are likely malabsorbing other nutrients in addition to lipid. Furthermore, we observe that the ablation of IFABP leads to marked alterations in intestinal morphology and secretory cell abundance.
Contributions of Convective and Orographic Gravity Waves to the Brewer–Dobson Circulation Estimated from NCEP CFSR
Authors: Kang Min-Jee , Chun Hye-Yeong , Song Byeong-Gwon 
Published: January 2020

Abstract
Contributions of convective gravity waves (CGWs) and orographic gravity waves (OGWs) to the Brewer–Dobson circulation (BDC) are examined and compared to those from resolved waves. OGW drag (OGWD) is provided by NCEP Climate Forecast System Reanalysis (CFSR), while CGW drag (CGWD) is obtained from an offline calculation of a physically based CGW parameterization with convective heating and background data provided by CFSR. CGWD contributes to the shallow branch of the BDC regardless of the season, while OGWD contributes to both the shallow and deep branches except for the summertime, when OGWs hardly propagate into the stratosphere. At 70 hPa, the annual-mean tropical upward mass fluxes from Eliassen–Palm flux divergence (EPD), OGWD, and CGWD are 68%, 7%, and 4% of the total mass flux, respectively. The tropical upward mass flux at 70 hPa shows an increasing trend during the time period from 1979 to 1998, with 28%, 18%, and 6% of the trend driven by EPD, OGWD, and CGWD, respectively. The width of the turnaround latitudes tends to narrow for the streamfunctions induced by OGWD and CGWD but tends to widen for that induced by EPD. The contributions of GWD from MERRA (MERRA-2) to the climatology and long-term trend of the BDC are 7% (7%) and 13% (4%), respectively, somewhat smaller than the contributions of CGWD plus OGWD, which are estimated from CFSR to be 12% and 20%, respectively.
Tropical Cyclone Wind Speed Retrieval from Dual-Polarization Sentinel-1 EW Mode Products
Authors: Gao Yuan , Guan Changlong , Sun Jian , Xie Lian 
Published: January 2020

AbstractRecent studies indicate that the cross-polarization synthetic aperture radar (SAR) images have the ability of retrieving high wind speed on ocean surface without wind direction input. This study presents a new approach for tropical cyclone (TC) wind speed retrieval utilizing thermal-noise-removed Sentinel-1 dual-polarization (VV + VH) Extra-Wide Swath (EW) Mode products. Based on 20 images of 9 TCs observed in the 2016 and 2018 and SAR-collocated European Centre for Medium-Range Weather Forecasts (ECMWF) fifth-generation reanalysis (ERA5) data and the National Oceanic and Atmospheric Administration (NOAA) Hurricane Research Division’s (HRD) Real-time Hurricane Wind Analysis System (H*Wind) data, a subswath-based geophysical model function (GMF) Sentinel-1 EW Mode Wind Speed Retrieval Model after Noise Removal (S1EW.NR) is developed and validated statistically. TC wind speed is retrieved by using the proposed GMF and the C-band model 5.N (CMOD5.N). The results show that the wind speeds retrieved by the S1EW.NR model are in good agreement with wind references up to 31 m s−1. The correlation coefficient, bias, and standard deviation between the retrieval results and reference wind speeds are 0.74, −0.11, and 3.54 m s−1, respectively. Comparison of the wind speeds retrieved from both channels suggests that the cross-polarized signal is more suitable for high–wind speed retrieval, indicating the promising capability of cross-polarization SAR for TC monitoring.
Safety of Outpatient Type 1 Thyroplasty
Authors: Patel Jena , Boon Maurits , Spiegel Joseph , Huntley Colin 
Published: January 2020

Objective: Type 1 thyroplasty is an established procedure for the treatment of vocal fold paralysis to improve voice and swallowing outcomes. At our institution, we commonly perform this procedure on an outpatient basis in medically stable patients. With this study, we assess the safety of outpatient thyroplasty by examining complication and readmission rates, need for revision surgery, and predictors of these outcome measures. Methods: We performed a retrospective review of patients undergoing outpatient type 1 thyroplasty for vocal fold paralysis between 2013 and 2018 at our institution. We documented the etiology of paralysis, comorbidities, and demographic data. Our primary outcome measures were complications, need for readmission, and need for revision surgery. Results: During the study period, 160 patients met our inclusion criteria. Mean age at time of surgery was 62.1 ± 13.9 years; there were 82 (51%) males and 78 (49%) females. Nine (5.6%) patients experienced major complications after surgery and 7 (4.4%) patients required unplanned readmission. Mean time to complication was 6.9 ± 9.7 days. There were no instances of postoperative airway compromise requiring intervention. There were no mortalities. Of those who underwent primary surgery, 22 (14%) patients required revision surgery. Conclusion: Given that complications tend to occur in a delayed fashion rather than in the acute postoperative period, same-day discharge seems reasonable as compared to overnight observation in medically stable patients undergoing type 1 thyroplasty. Level of Evidence: IV
Optical coherence tomography angiography findings in young β-thalassemia patients
Authors: Güler Kazancı Elif , Korkmaz Muhammet Furkan , Can Mehmet Erol 
Published: January 2020

Purpose: The purpose was to evaluate retinal vascular parameters by optical coherence tomography angiography in β-thalassemia major patients. Methods: Thirty-three patients with β-thalassemia major (study group) and 29 healthy children (control group) were enrolled in the study. All subjects underwent a complete ocular examination. The mean foveal avascular zone, non-flow area, foveal avascular zone perimeter, acircularity index of foveal avascular zone, foveal density, the superficial capillary plexus, and deep capillary plexus were scanned using 6 × 6 mm optical coherence tomography angiography scans centered on the macula. Superficial capillary plexus and deep capillary plexus were also scanned centered on the optic disk. We collected data on histories of patients, and hemoglobin and ferritin were also studied from both groups. Results: The mean age was 13.85 ± 4.69 years (range: 4–21 years) in β-thalassemia major group and 12.59 ± 3.66 years (range: 6–18 years) in the control group. The mean foveal avascular zone value was 0.265 ± 0.11 mm2 in the study group and 0.296 ± 0.12 mm2 in the control group. The mean non-flow area value was 0.468 ± 0.12 mm2 in the study group and 0.479 ± 0.14 mm2 in the control group ( p > 0.05). Differences in the mean values for foveal density and acircularity index were statistically significant between the study group and control group ( p < 0.05, p = 0.026, and p = 0.026, respectively). Superficial capillary plexus and deep capillary plexus were not a significant difference between the study and control groups in 6 × 6 mm scans on macula and 4.5 × 4.5 mm scans on optic disk area ( p > 0.05). Acircularity index was negatively correlated ( r = −0.292, p = 0.026), and foveal density was positively correlated with hemoglobin ( r = 0.292, p = 0.026). Conclusion: By using optical coherence tomography angiography, we detected foveal microvascular changes in young β-thalassemia patients before significant ocular anomalies development.
Overexpression of a modified eIF4E regulates potato virus Y resistance at the transcriptional level in potato
Authors: Gutierrez Sanchez Pablo A. , Babujee Lavanya , Jaramillo Mesa Helena , Arcibal Erica , Gannon Megan , Halterman Dennis , Jahn Molly , Jiang Jiming , Rakotondrafara Aurélie M. 
Published: January 2020

Abstract
Background
Potato virus Y (PVY) is a major pathogen of potatoes with major impact on global agricultural production. Resistance to PVY can be achieved by engineering potatoes to express a recessive, resistant allele of eukaryotic translation initiation factor eIF4E, a host dependency factor essential to PVY replication. Here we analyzed transcriptome changes in eIF4E over-expressing potatoes to shed light on the mechanism underpinning eIF4E-mediated recessive PVY resistance.

Results
As anticipated, modified eIF4E-expressing potatoes demonstrated a high level of resistance, eIF4E expression, and an unexpected suppression of the susceptible allele transcript, likely explaining the bulk of the potent antiviral phenotype. In resistant plants, we also detected marked upregulation of genes involved in cell stress responses.

Conclusions
Our results reveal a previously unanticipated second layer of signaling attributable to eIF4E regulatory control, and potentially relevant to establishment of a broader, more systematic antiviral host defense.