bluuebunny/crossref_metadata_2025_split huggingface dataset:
mTOR-Inhibitor-induzierte Pneumonitis bei einem 72-jährigen Patienten nach Herztransplantation
Authors: Kasper Philipp , Göbel Heike , Michels Guido 
Published: February 2020

Zusammenfassung
Anamnese Ein 72-jähriger herztransplantierter Patient stellte sich mit progredienter Belastungsdyspnoe in der Klinik vor. Zuvor war infolge einer zunehmenden Nierenfunktionseinschränkung die Umstellung seiner immunsuppressiven Therapie auf den mTOR-Inhibitor Everolimus erfolgt. Bei initialem Verdacht einer ambulant erworbenen Pneumonie erfolgte zunächst die Einleitung einer empirischen antiinfektiven Therapie, worunter es jedoch zu einer weiteren Verschlechterung mit Ausbildung eines akuten Lungenversagens und Beatmungspflichtigkeit kam.
Untersuchungen Im Rahmen der erweiterten Diagnostik erfolgte eine transbronchiale Lungenbiopsie, wobei sich das Bild einer medikamentös-toxischen Lungenparenchymschädigung zeigte.
Diagnose Klinisch und pathologisch wurde die Arbeitsdiagnose einer mTOR-Inhibitor-induzierten Pneumonitis gestellt.
Therapie und Verlauf Die bestehende Everolimus-Therapie wurde umgehend beendet und eine hochdosierte Glukokortikoid-Therapie initiiert, woraufhin zunächst eine rasche respiratorische Stabilisierung eintrat.
Folgerung Die Everolimus-induzierte Pneumonitis repräsentiert eine seltene, jedoch schwerwiegende Komplikation, welche bei allen Patienten unter Therapie mit mTOR-Inhibitoren und neu aufgetretener Belastungsdyspnoe differenzialdiagnostisch in Erwägung gezogen werden sollte.
Loneliness as a mediator of the impact of social isolation on cognitive functioning of Chinese older adults
Authors: Yang Rumei , Wang Haocen , Edelman Linda S , Tracy Eunjin L , Demiris George , Sward Katherine A , Donaldson Gary W 
Published: February 2020

Abstract

Background and Objective
older adults have increased risk of social isolation, loneliness and cognitive functioning impairment, but the relationships among these factors are not conclusive. We investigated the potential mediation mechanism of loneliness on the association between social isolation and cognitive functioning among Chinese older adults within their cultural context.

Design
secondary analysis of the baseline wave (2011–12) of the harmonised China Health and Retirement Longitudinal Study.

Setting and Subjects
community-dwelling older adults in China (N = 7,410 participants aged 60–101 years).

Methods
we applied a multiple indicator multiple cause approach to determine whether the construct of social isolation is well defined by four indicators (social activity engagement, weekly adult children contact, caregiving for grandchildren and living alone) and used structural equation modelling to examine the direct and indirect effects among variables of interest.

Results
the results demonstrated that social activity engagement, weekly adult children contact and caregiving for grandchildren were significantly related to social isolation (β = −0.26 to −0.28) (Living alone was fixed to 1 for model identification.) The indirect effect of social isolation on cognitive functioning through loneliness was significant (β = −0.15), indicating loneliness was an important mediator. However, the direct effect of social isolation on cognitive functioning also remained significant (β = −0.83), suggesting a partial mediation effect.

Conclusions
our study highlights the mediation role of loneliness in the relationship between social isolation and cognitive functioning among Chinese older adults. The findings support the beneficial effects of maintaining social relations and coping with feelings of loneliness on older adults’ cognitive functioning.
Positive and negative experiences and life satisfaction among spousal caregivers for frail older adults in urban China: a parallel process model
Authors: Jiang Nan , Lu Nan , Sun Qian , Lou Vivian W Q 
Published: February 2020

Abstract

Objectives
Previous literature has suggested that negative and positive aspects of spousal caregiving co-exist. However, positive and negative experiences were often examined independently. This study aimed to empirically test a parallel process model of spousal caregiving.

Methods
This cross-sectional survey of family caregiving involved 269 frail older adults living in Shanghai, China, in 2016. Quota sampling was conducted to find community-dwelling frail older adults with a primary caregiver. Path analysis was used to identify the relationship between negative and positive caregiving experiences and life satisfaction.

Results
We found two independent paths towards life satisfaction: (i) activities of daily living were negatively associated with burden, and burden was associated with lower life satisfaction; and (ii) spousal caregivers’ self-reported health and financial state were positively associated with positive appraisal, and positive appraisal was associated with higher life satisfaction. Caregiving time contributed to both aspects of caregiving experiences. The covariance between caregiving burden and positive appraisals was not statistically significant.

Conclusion
Spousal caregiving involves a parallel process. Negative and positive experiences are separate constructs and their associations with life satisfaction vary. We advocate for policy and interventions that promote positive views of caregiving that encourage caregivers to develop a high level of overall life satisfaction despite the hardships of their caregiving tasks.
GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A
Authors: Shimamoto Kazumi , Tanimoto Keiji , Fukazawa Takahiro , Nakamura Hideaki , Kanai Akinori , Bono Hidemasa , Ono Hiromasa , Eguchi Hidetaka , Hirohashi Nobuyuki 
Published: February 2020

Abstract
We previously demonstrated that expression of a Krüppel-like zinc finger transcription factor, GLIS1, dramatically increases under hypoxic conditions via a transcriptional mechanism induced by HIF-2α cooperating with AP-1 members. In this study, we focused on the functional roles of GLIS1 in breast cancer. To uncover its biological function, the effects of altered levels of GLIS1 in breast cancer cell lines on cellular growth, wound-healing and invasion capacities were assessed. Knockdown of GLIS1 using siRNA in BT-474 cells resulted in significant growth stimulation under normoxia, while attenuation was found in the cell invasion assay under hypoxic conditions. In MDA-MB-231 cells expressing exogenous 3xFLAG-tagged GLIS1, GLIS1 attenuated cell proliferation and enhanced cell mobility and invasion capacities under normoxia. In addition, breast cancer cells expressing GLIS1 acquired resistance to irradiation. Whole transcriptome analysis clearly demonstrated that downstream signals of GLIS1 are related to various cellular functions. Among the genes with increased expression, we focused on WNT5A. Knockdown of WNT5A indicated that enhancement of acquired cell motility in the MDA-MB-231 cells expressing GLIS1 was mediated, at least in part, by WNT5A. In an analysis of publicly available data, patients with estrogen receptor-negative breast cancer showing high levels of GLIS1 expression showed much worse prognosis than those with low levels. In summary, hypoxia-induced GLIS1 plays significant roles in breast cancer cells via regulation of gene expression related to cell migration and invasion capacities, resulting in poorer prognosis in patients with advanced breast cancer.
A Generalizable Multivariate Brain Pattern for Interpersonal Guilt
Authors: Yu Hongbo , Koban Leonie , Chang Luke J , Wagner Ullrich , Krishnan Anjali , Vuilleumier Patrik , Zhou Xiaolin , Wager Tor D 
Published: February 2020

Abstract
Feeling guilty when we have wronged another is a crucial aspect of prosociality, but its neurobiological bases are elusive. Although multivariate patterns of brain activity show promise for developing brain measures linked to specific emotions, it is less clear whether brain activity can be trained to detect more complex social emotional states such as guilt. Here, we identified a distributed guilt-related brain signature (GRBS) across two independent neuroimaging datasets that used interpersonal interactions to evoke guilt. This signature discriminated conditions associated with interpersonal guilt from closely matched control conditions in a cross-validated training sample (N = 24; Chinese population) and in an independent test sample (N = 19; Swiss population). However, it did not respond to observed or experienced pain, or recalled guilt. Moreover, the GRBS only exhibited weak spatial similarity with other brain signatures of social-affective processes, further indicating the specificity of the brain state it represents. These findings provide a step toward developing biological markers of social emotions, which could serve as important tools to investigate guilt-related brain processes in both healthy and clinical populations.
Markets for data
Authors: Koutroumpis Pantelis , Leiponen Aija , Thomas Llewellyn D W 
Published: February 2020

Abstract
Although datasets are abundant and assumed to be immensely valuable, they are not being shared or traded openly and transparently on a large scale. We investigate the nature of data trading with a conceptual market design approach and demonstrate the importance of provenance to overcome appropriability and quality concerns. We consider the requirements for efficient data exchange, comparing existing trading arrangements against efficient market models and show that it is possible to achieve either large markets with little control or small markets with greater control. We describe some future research directions.
Pointwise Convergence of the Schrödinger Flow
Authors: Compaan Erin , Lucà Renato , Staffilani Gigliola 
Published: February 2020

Abstract
In this paper we address the question of the pointwise almost everywhere limit of nonlinear Schrödinger flows to the initial data, in both the continuous and the periodic settings. Then we show how, in some cases, certain smoothing effects for the non-homogeneous part of the solution can be used to upgrade to a uniform convergence to zero of this part, and we discuss the sharpness of the results obtained. We also use randomization techniques to prove that with much less regularity of the initial data, both in continuous and the periodic settings, almost surely one obtains uniform convergence of the nonlinear solution to the initial data, hence showing how more generic results can be obtained.
A Really Big Button That Doesn’t Do Anything? The Anti-NME Clause in US Trade Agreements Between Law and Geoeconomics
Authors: Vidigal Geraldo 
Published: February 2020

Abstract
The United States-Mexico-Canada Agreement (USMCA) features a clause, dubbed ‘anti-China’, which sets out legal consequences in case one of the parties negotiates or enters into a free trade agreement (FTA) with a nonmarket economy (NME). A similarly worded objective appears among the negotiating objectives of the US for FTAs with the European Union, Japan, and the United Kingdom. This article examines the anti-NME clause, arguing that its concrete legal consequences are less relevant than its symbolic effects. The USMCA clause itself is difficult to replicate in bilateral agreements, since it depends on cooperation between the two nonsigning parties. Its operation is nonetheless similar to that of two unilateral remedies available under the law of treaties, permitting a reasonable assessment that the clause, if it follows its original design, will aim to permit termination of bilateral US FTAs in response to the other party entering into an NME FTA. While such a clause would offer little in terms of concrete effects if added to agreements that already permit unilateral withdrawal, its greatest value may not be in its legal effects but in its legitimating and signaling properties, which push USMCA parties to establish a common front in the ‘geoeconomic’ dispute between the United States and China.
Successful field performance in warm and dry environments of soybean expressing the sunflower transcription factor HB4
Authors: Ribichich Karina F , Chiozza Mariana , Ávalos-Britez Selva , Cabello Julieta V , Arce Augustin L , Watson Geronimo , Arias Claudia , Portapila Margarita , Trucco Federico , Otegui Maria E , Chan Raquel L 
Published: February 2020

Abstract
Soybean yield is limited primarily by abiotic constraints. No transgenic soybean with improved abiotic stress tolerance is commercially available. We transformed soybean plants with genetic constructs able to express the sunflower transcription factor HaHB4, which confers drought tolerance to Arabidopsis and wheat. One line (b10H) carrying the sunflower promoter was chosen among three independent lines because it exhibited the best performance in seed yield, and was evaluated in the greenhouse and in 27 field trials in different environments in Argentina. In greenhouse experiments, transgenic plants showed increased seed yield under stress conditions together with greater epicotyl diameter, larger xylem area, and increased water use efficiency compared with controls. They also exhibited enhanced seed yield in warm and dry field conditions. This response was accompanied by an increase in seed number that was not compensated by a decrease in individual seed weight. Transcriptome analysis of plants from a field trial with maximum difference in seed yield between genotypes indicated the induction of genes encoding redox and heat shock proteins in b10H. Collectively, our results indicate that soybeans transformed with HaHB4 are expected to have a reduced seed yield penalty when cultivated in warm and dry conditions, which constitute the best target environments for this technology.
Deducing Crystallization Sequence of Magmas from Spatial Distribution of Crystals in Rocks
Authors: Špillar Václav 
Published: February 2020

Abstract
The order of crystallization of minerals from melt is of prime importance for an understanding of magma fractionation and chemical differentiation from the magma chamber to the planetary scale. Determination of the crystallization sequence based on petrographic observations, however, is often ambiguous; especially in multiply saturated, nearly eutectic felsic melts. This paper presents a novel approach to estimate the order of crystallization of minerals in igneous systems based on a quantitative study of their spatial distributions. Statistical modelling of crystallization demonstrates that later crystallizing mineral phases are generally more clustered. A simple inversion model is then derived to calculate the crystallization sequence and the volume fraction of older minerals present in the system at the onset of crystallization of a later (younger) phase. Application of the model to a sample of equigranular granodiorite (Fichtelgebirge granite batholith, Germany) indicates that plagioclase was the first liquidus phase. It was followed by biotite, K-feldspar, and quartz at 41, 48, and 63 vol. % crystallized, respectively, which is in qualitative agreement with experimental phase equilibria results for moderately hydrous granitic melts. If phase equilibria for a given composition are known or assumed, the crystallization sequence thus constrains the intensive variables (e.g., water content) and their evolution during magma solidification. The model thus provides a novel and independent approach to reconstruct the magma crystallization path that would be inaccessible by other methods.
Sevoflurane and Parkinson’s Disease
Authors: Tsai Sheng-Tzung , Tseng Guo-Fang , Kuo Chang-Chih , Chen Tsung-Ying , Chen Shin-Yuan 
Published: February 2020

Abstract

Background
General anesthetics-induced changes of electrical oscillations in the basal ganglia may render the identification of the stimulation targets difficult. The authors hypothesized that while sevoflurane anesthesia entrains coherent lower frequency oscillations, it does not affect the identification of the subthalamic nucleus and clinical outcome.

Methods
A cohort of 19 patients with Parkinson’s disease with comparable disability underwent placement of electrodes under either sevoflurane general anesthesia (n = 10) or local anesthesia (n = 9). Microelectrode recordings during targeting were compared for neuronal spiking characteristics and oscillatory dynamics. Clinical outcomes were compared at 5-yr follow-up.

Results
Under sevoflurane anesthesia, subbeta frequency oscillations predominated (general vs. local anesthesia, mean ± SD; delta: 13 ± 7.3% vs. 7.8 ± 4.8%; theta: 8.4 ± 4.1% vs. 3.9 ± 1.6%; alpha: 8.1 ± 4.1% vs. 4.8 ± 1.5%; all P < 0.001). In addition, distinct dorsolateral beta and ventromedial gamma oscillations were detected in the subthalamic nucleus solely in awake surgery (mean ± SD; dorsal vs. ventral beta band power: 20.5 ± 6.6% vs. 15.4 ± 4.3%; P < 0.001). Firing properties of subthalamic neurons did not show significant difference between groups. Clinical outcomes with regard to improvement in motor and psychiatric symptoms and adverse effects were comparable for both groups. Tract numbers of microelectrode recording, active contact coordinates, and stimulation parameters were also equivalent.

Conclusions
Sevoflurane general anesthesia decreased beta-frequency oscillations by inducing coherent lower frequency oscillations, comparable to the pattern seen in the scalp electroencephalogram. Nevertheless, sevoflurane-induced changes in electrical activity patterns did not reduce electrode placement accuracy and clinical effect. These observations suggest that microelectrode-guided deep brain stimulation under sevoflurane anesthesia is a feasible clinical option.

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A Mixed-Method Study of Providing and Implementing a Support Model Focusing on Systematic Work Environment Management
Authors: Hellman Therese , Molin Fredrik , Svartengren Magnus 
Published: February 2020

Aims:
To explore how a support model (Stamina) targeting the systematic work environment management was experienced, provided and implemented in Swedish municipalities.

Methods:
A mixed method approach was applied, including material from interviews and questionnaire. The questionnaire was answered by 123 persons (67.5%), and 18 participants were interviewed twice during a one year period. Data were analysed using descriptive statistics and qualitative content analysis.

Results:
The participants followed the structure of the Stamina model in their practical work. Still, there was variation in the practical provision of the model. The implementation was supported by their organizations and was influenced by various actors. Creating commitment was an essential part to facilitate implementation.

Conclusion:
To promote implementation of the Stamina model, there is a need to create commitment among stakeholders that will participate in the implementation.
A concept analysis of nurse practitioner autonomy
Authors: Peacock Michelle , Hernandez Stephen 
Published: February 2020

ABSTRACTBackground:Nurse practitioner (NP) autonomy is often misunderstood and misconstrued. These misconceptions cause a confusing interplay of words that impedes advocating for policy change and ultimately hinders the profession.Objective:To develop a clear definition of NP autonomy to describe the professional role.Data sources:Walker and Avant's method of concept analysis was used to undertake a concept analysis of NP autonomy. The terms used to search for possible uses and definitions of NP autonomy in electronic databases included NP, autonomy, and concept analysis. In addition, the websites for nursing organizations, Google, Google Scholar, and the Merriam-Webster dictionary were searched and included in this analysis. This search yielded 29 articles, consisting of literature reviews, meta-synthesis, position papers, and qualitative and quantitative studies.Conclusions:Nurse practitioner autonomy should be defined as the NP's use of their experience, clinical judgment, and responsibility to practice without restriction in professional collaboration with other health care professionals. Autonomy allows NPs to practice to the maximum extent of their advanced education, participate in productive and voluntarily collaborations, and continue to positively influence health care discrepancies throughout the United States.Implications for practice:This concept analysis provides a clear definition of NP autonomy. In addition, it explains the difference between the concepts of NP autonomy and full practice authority. Clear definitions of the concepts of NP autonomy and full practice authority will be beneficial in advocating and advancing policy on behalf of NPs.
Dynamic balancing of the cleaning unit used in agricultural thresher using a non-dominated sorting Jaya algorithm
Authors: Singh Prem , Chaudhary Himanshu 
Published: February 2020

Purpose
This paper aims to propose a dynamically balanced mechanism for cleaning unit used in agricultural thresher machine using a dynamically equivalent system of point masses.

Design/methodology/approach
The cleaning unit works on crank-rocker Grashof mechanism. This mechanism can be balanced by optimizing the inertial properties of each link. These properties are defined by the dynamic equivalent system of point masses. Parameters of these point masses define the shaking forces and moments. Hence, the multi-objective optimization problem with minimization of shaking forces and shaking moments is formulated by considering the point mass parameters as the design variables. The formulated optimization problem is solved using a posteriori approach-based algorithm i.e. the non-dominated sorting Jaya algorithm (NSJAYA) and a priori approach-based algorithms i.e. Jaya algorithm and genetic algorithm (GA) under suitable design constraints.

Findings
The mass, center of mass and inertias of each link are calculated using optimum design variables. These optimum parameters improve the dynamic performance of the cleaning unit. The optimal Pareto set for the balancing problem is measured and outlined in this paper. The designer can choose any solution from the set and balance any real planar mechanism.

Originality/value
The efficiency of the proposed approach is tested through the existing cleaning mechanism of the thresher machine. It is found that the NSJAYA is computationally more efficient than the GA and Jaya algorithm. ADAMS software is used for the simulation of the mechanism.
Traces left by Herbert Brün that orient my cybernetics (Maybe)
Authors: Lombardi Judith 
Published: February 2020

Purpose
Herbert Brün was a composer of many things including electronic and computer music. His compositions were, by design, nested in his passions for designing a new society – without violence. In this article, the author attempts to address several of Brün’s concepts relevant to his desire for social change. This paper was stimulated by a panel discussion about Brün at the 2018 American Society for Cybernetics (ASC) conference “Framing a Reality and How It Matters in a Shared World.”

Design/methodology/approach
Herbert Brün nested his communication in what he labeled “anticommunication,” which requires a listener to generate new ways of listening. As a video ethnographer, the author had many opportunities to videotape Brün, beginning with our first encounter at the 1992 ASC Conference in Washington State. During the past several decades, the author has composed a variety of movies in which the video footage of Brün and others that the author associates with cybernetics is used. Excerpts from many of these movies are embedded in the links located in the references section of this paper.

Findings
Brün’s cybernetic formulations for designing social transformations explored in this paper include his ideas on floating hierarchies, anticommunication, his notions on a circularity of needs, peace as a need, articulating desires, composing as an element of daily life, and the retardation of decay.

Originality/value
It is the author’s desire that this paper encourages the reader to explore some of Herbert Brün’s formulations for designing social change and transformations.