bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dominance Effects and Functional Enrichments Improve Prediction of Agronomic Traits in Hybrid Maize
Authors: Ramstein Guillaume P , Larsson Sara J , Cook Jason P , Edwards Jode W , Ersoz Elhan S , Flint-Garcia Sherry , Gardner Candice A , Holland James B , Lorenz Aaron J , McMullen Michael D , Millard Mark J , Rocheford Torbert R , Tuinstra Mitchell R , Bradbury Peter J , Buckler Edward S , Romay M Cinta 
Published: March 2020

Abstract
Single-cross hybrids have been critical to the improvement of maize (Zea mays L.), but the characterization of their genetic architectures remains challenging. Previous studies of hybrid maize have shown the contribution of within-locus complementation effects (dominance) and their differential importance across functional classes of loci. However, they have generally considered panels of limited genetic diversity, and have shown little benefit from genomic prediction based on dominance or functional enrichments. This study investigates the relevance of dominance and functional classes of variants in genomic models for agronomic traits in diverse populations of hybrid maize. We based our analyses on a diverse panel of inbred lines crossed with two testers representative of the major heterotic groups in the U.S. (1106 hybrids), as well as a collection of 24 biparental populations crossed with a single tester (1640 hybrids). We investigated three agronomic traits: days to silking (DTS), plant height (PH), and grain yield (GY). Our results point to the presence of dominance for all traits, but also among-locus complementation (epistasis) for DTS and genotype-by-environment interactions for GY. Consistently, dominance improved genomic prediction for PH only. In addition, we assessed enrichment of genetic effects in classes defined by genic regions (gene annotation), structural features (recombination rate and chromatin openness), and evolutionary features (minor allele frequency and evolutionary constraint). We found support for enrichment in genic regions and subsequent improvement of genomic prediction for all traits. Our results suggest that dominance and gene annotations improve genomic prediction across diverse populations in hybrid maize.
Rif1 Functions in a Tissue-Specific Manner To Control Replication Timing Through Its PP1-Binding Motif
Authors: Armstrong Robin L , Das Souradip , Hill Christina A , Duronio Robert J , Nordman Jared T 
Published: March 2020

Abstract
Replication initiation in eukaryotic cells occurs asynchronously throughout S phase, yielding early- and late-replicating regions of the genome, a process known as replication timing (RT). RT changes during development to ensure accurate genome duplication and maintain genome stability. To understand the relative contributions that cell lineage, cell cycle, and replication initiation regulators have on RT, we utilized the powerful developmental systems available in Drosophila melanogaster. We generated and compared RT profiles from mitotic cells of different tissues and from mitotic and endocycling cells of the same tissue. Our results demonstrate that cell lineage has the largest effect on RT, whereas switching from a mitotic to an endoreplicative cell cycle has little to no effect on RT. Additionally, we demonstrate that the RT differences we observed in all cases are largely independent of transcriptional differences. We also employed a genetic approach in these same cell types to understand the relative contribution the eukaryotic RT control factor, Rif1, has on RT control. Our results demonstrate that Rif1 can function in a tissue-specific manner to control RT. Importantly, the Protein Phosphatase 1 (PP1) binding motif of Rif1 is essential for Rif1 to regulate RT. Together, our data support a model in which the RT program is primarily driven by cell lineage and is further refined by Rif1/PP1 to ultimately generate tissue-specific RT programs.
When Pigs Fly: A Multidisciplinary Approach to Navigating a Critical Heparin Shortage
Authors: Rosovsky Rachel P. , Barra Megan E. , Roberts Russel J. , Parmar Alison , Andonian Jennifer , Suh Larren , Algeri Suzanne , Biddinger Paul D. 
Published: March 2020

Abstract

A recent outbreak of African swine fever (ASF) in China has claimed the lives of millions of pigs, and although this virus has no health impacts on humans, the disruption of the global pig population has far-reaching negative impacts on economic and pork-derived products, including the creation of the critical drug heparin. The active pharmaceutical ingredient in heparin is derived from pig intestines, and because of the ASF outbreak, the U.S. faces an imminent shortage of heparin. This drug shortage has the potential for profound implications, as heparin is used in a substantial and varied number of medical conditions. In response to notification of the heparin shortage crisis, our institution, Massachusetts General Hospital, activated its Hospital Incident Command System to streamline organization of major stakeholders and oversee operational and clinical activities required to mitigate the potential risks and optimize alternative effective strategies. This article describes the essential elements of our institution's emergency response plan, including detailed clinical algorithms developed by our experts for maximal heparin conservation and waste reduction by promoting safe and effective alternative strategies. Through this practice, we have also identified opportunities to change providers’ prescribing and utilization behaviors for the better. As the ASF has not yet been contained and this crisis continues, the strategies and policies employed by our institution can provide a framework for other institutions to tackle this ongoing challenge and future drug shortage crises.
Image in Media Landscape: a Linguistic Discourse Portrait
Authors: Muzychuk Tatyana , Litovkina Anna 
Published: March 2020

The review is a critical response to the monograph «Image advertorial as phenomenon of the contemporary media landscape» by L.G. Yegorova.
The monograph makes a deep linguistic discourse analysis of the notion of media text, and shows relevant category features and ontological properties of image advertorial. The work is a coherent inter-disciplinary research, where the genre of image advertorial in Russian mass media discourse is studied from the position of linguo-sociological culturology and psycholinguistics, and from a communicative-pragmatic point of view.
Petrography and Petrochemical Characteristics of Rare Metal Pegmatites around Oro, Southwestern Nigeria
Authors: Oyebamiji Abiola O. 
Published: March 2020

Petrographic and geochemical evaluation of pegmatite bodies occurring as discontinuous dykes have been studied in Oro area of southwestern Nigeria, with a view to determine the compositional characteristics that may be related to Ta-Nb mineralization potentials. They are found intruding semi discordantly, the older assemblages of quartz mica schist and granite gneiss.
A total of twenty-eight samples comprising whole rock pegmatites and eluvial soils were analyzed for major, trace and rare earth elements using (ICP-AES) geochemical method which show the pegmatite samples to be generally highly siliceous with SiO2 values ranging from (71.49-97.77%) with an average of 86.43% in the whole rock samples, and it also ranges from (41.88-57.99%) with an average of 48.43% in the eluvial soil samples, while Al2O3 content is as high as 25.87% in the eluvial soil samples and 6.86% in the whole rock samples depicting the complexity of the pegmatite rock.
Variation plots of K/Rb versus Rb, Ta versus Rb, Ta versus Nb, Ta versus K/Cs, Ta versus Cs+Rb and Ta versus Cs discriminant plot indicate the potentials of rare metal mineralization.
A Review on Chemical Synthesis Process of Platinum Nanoparticles
Authors: Islam Md. Aminul , Bhuiya M. Anwarul Kabir , Islam M. Saidul 
Published: March 2020

Nanoparticles are key components in the advancement of future energy technologies; thus, strategies for preparing nanoparticles in large volume by techniques that are cost-effective are required. In the substitution of fossil-fuels by renewable energy resources, nanometersized particles play a key role for synthesizing energy vectors from varying and heterogeneous biomass feedstocks. They are extensively used in reformers for the production of hydrogen from solid, liquid, or gaseous energy carriers. Catalyst activities depend critically on their size-dependent properties. Nanoparticles are further indispensable as electrocatalysts in fuel cells and other electrochemical converters. The desire to increase the activity per unit area, and decrease the necessary amount of the expensive catalytic standard, It is clear that performance and commercialization of fuel cells depend on electrode materials performance. The application of pt nanomaterials as an electrode in the field of fuel cell has become a new, growing area of interest in recent years. We review chemical process for synthesis of pt nanoparticles. Recent developments in syntheses process of pure & mixed platinum nanoparticles has briefly reviewed specifically for applications in fuel cells. As the physicochemical properties of noble-metal nanostructures are strongly dependent upon shape and size, the development of reliable synthesis methods for the production of nanocrystals with well-defined size and morphology have been discussed briefly. The role of nanostructured supports for the nanoparticles, such as ordered mesoporous carbon, dendrimer have also discussed. And size of the nanoparticles obtained in deferent process and their temperature dependence has also discussed briefly.
The Effect of Time Management in Shadow Puppet Performance on the Audience Satisfaction
Authors: Basuki Ribut , Dwi Setiawan Dwi , Joko Riyanto Theophilus , Jiwa Husada Tarigan Zeplin 
Published: March 2020

Indonesia has one of the greatest diversities in the world as reflected by its many cultures, languages, customs, and beliefs. This diversity can be easily seen in the East Java region which, despite its Javanese ethnic majority, is also populated by other ethnics, sub ethnics, and mixed groups. Shadow puppet theatre is a form of public attraction long existing in Java, even before the era of the Majapahit Empire. It is usually performed at night and takes a considerable time. In this multidisciplinary paper, it is hypothesized that good time management will increase audience satisfaction and in turn contribute to the sustainability of the theatre and Javanese culture. Based on the analysis of the survey, using partial least square by java web start program, it is found that, first, shadow puppet attraction positively affects to time management as 0.720. Further, the attraction leads to audience satisfaction as 0.558. Lastly, time management affects audience satisfaction as 0.258.
Keywords: audience satisfaction; wayang attraction; wayang time management.
An Optimization Algorithms-based Approach to District Health System Population Areas in Iran
Authors: Tayyebi Javad , Mostafayi Darmian Sobhan 
Published: March 2020

Background: One of important subject in the operations' management fields is partitioning matter that was investigated in the study. This topic has recently received more attention from researchers of the healthcare management systems' field. This subject is important because planning about improvement of the healthcare system structure is considered as one of the most important management problems in each society. The goal of solving this problem was to district a society into several areas, so that each area can cover its health services completely.
Methods: This fundamental-applied study was conducted based on the Genetic optimization algorithm, particle swarm, and differential evolution to improve the current structures with regard to the existing health structure in Iran. Moreover, the health system strategic model was applied to categorize the population regions into 10 partitions. According to nature of the investigated problem, the objective function is maximizing the equilibrium amount in each district. The constraints included exclusive assignment and not-existing unusual assignment. Unusual assignment is defined as existence of no contiguity and holes in partitions.
Results: According to the obtained results, the particle swarm algorithm had the most efficiency, while differential evolution had the lowest efficiency. However, the stated constraints were satisfied completely in all algorithms, which represented appropriate efficiency of the modified algorithm in the generation solutions.
Conclusion: The results obtained from solving this problem can be used as a useful tool in improving the existing healthcare system in Iran.
Reviewing the Status and Experience of Outsourcing Policy in Healthcare: A review study
Authors: Ahmadizadeh Elahe , Tajvar Maryam , Ahmadi Batoul , Ahmadi Batoul 
Published: March 2020

Background: Outsourcing is a method and tool for delivering services to increase effectiveness and efficiency. Regarding the outsourcing policies, identifying experiences and outsourcing records is essential. In this regard, the present study aimed at examining the status and experience of outsourcing policy in the health sector as a review study.
Methods: The present systematic review was carried out by searching Persian language articles from sources such as Magiran, SID, Hospital and Medical Education Magazines, Handouts, and Announcements and English language articles from sources indexed in Google scholar, PubMed, Scopus databases. The authors search for English and Persian language articles from 2000 until 2018. The following keywords were used in the search outsourcing, private sector, purchasing, contracting, public-private participation. A total of 25 articles were entered in the final analysis according to the inclusion criteria.
Results: Based on the results, outsourcing improves the quality, satisfaction of patients, and efficacy in most cases. The findings also suggested that outsourcing policies needed to be prescriptive and should be taken into consideration.
Conclusion: Hospitals should note that in the case of assigning a unit and transferring it to other parts not related to their expertise, it is not really possible to accept the transfer's general and absolute success in improving efficiency and effectiveness and reducing costs. The outsourcing policies need to relevant assumptions and requirements to succeed.
Evaluation of Patient's Dose and Estimate of Cancer Risk in Electrophysiology Studies and Ablation in Cath Lab Center of Afshar Hospital, Yazd, Iran
Authors: Bouzarjomehri Fatollah , Omidvar Fereshteh , Zare Mohammad Hossein , Nakhaeine Nejad Mashallah 
Published: March 2020

Introduction: Today electrophysiology studies and ablation have been developed due to increasing arrhythmias disorder of heart. In these diagnostic – treatments methods, the use of fluoroscopy can be causes patient radiation dose, therefore evaluation of patient's absorbed dose is necessary to protection of the radiation. The aim of this study was to evaluate the absorbed dose in patients undergoing electrophysiology and cardiac ablation and to estimate their risk of cancer in Yazd Afshar Hospital.
Methods: This study was a cross-sectional study. In this study, the mean absorbed dose of referral patients for electrophysiology studies and ablation had been measured in the cat. Lab of Afshar Hospital, Yazd. The dosimeter had been used in this research was KAP meter, the M4 DIAMENTOR made in Germany that was able to measure dose-area product and time of the fluoroscopy. The patient effective dose was calculated by the PCXMC software from dose-area product.
Results: The mean dose-area in ablation and electrophysiology studies was respectively 153.34±105.32 and 5.62 14.88 Gy.cm2 and the radiation time range was recorded 3.32 to 68.65 minutes and 1.03 to 6.28 minutes, respectively. The mean effective dose of ablation and electrophysiology studies were respectively 16.38 and 1.65 mSv. The cancer risk per ten thousands of patients, who were under the ablation and electrophysiology examinations were estimated 13 and 1.3 people, respectively.
Conclusion: Increasing of patient dose due to ablation in this study relation to the other studies can be due to long old of image intensifier device.
Cesarean Section and Maternal-fetal Mortality Rates in Nigeria: An Ecological Lens into the Last Decade
Authors: Galadanci Hadiza , Dongarwar Deepa , K Wolfgang , Shittu Oladapo , Yusuf Murtala , Abdurrahman Sadiq , Lufadeju Dolapo , Salihu Hamisu M. 
Published: March 2020

Background or Objectives: Despite the global decline in maternal mortality within the last decade, women continue to die excessively from pregnancy-related complicationsin developing countries. We assessed the trends in maternal mortality, fetal mortality and cesarean section (C-Section) rates within 25 selected Nigerian hospitals over the last decade.
Methods: Basic obstetric data on all deliveries were routinely collected by midwives using the maternity record book developed for the project in all the participating hospitals. Trends of C-Section Rates (CSR), Maternal Mortality Rates (MMR), Fetal Mortality Rates (FMR) and Spontaneous Vaginal Delivery rates (SVD) were calculated using joinpoint regression models.
Results: The annual average percent change in CSR was 12.2%, which was statistically significant, indicating a rise in CSR over the decade of the study. There was a noticeable fall in MMR from a zenith of about 1,868 per 100,000 at baseline down to 1,315/100,000 by the end of the study period, representing a relative drop in MMR of about 30%. An average annual drop of 3.8% in FMR and 1.5% drop in SVD over time were noted over the course of the study period.
Conclusion and Global Health Implications: We observed an overall CSR of 10.4% and a significant rise in CSR over the 9-year period (2008-2016) of about 108% across hospital facilities in Nigeria. Despite the decrease in MMR, it was still high compared to the global average of 546 maternal deaths per 100 000 livebirths. The FMR was also high compared with the global average. The MMR found in this study clearly indicates that Nigeria is far behind in making progress toward achieving the Sustainable Development Goal 3 (SGD 3) which aims to reduce the global MMR to less than 70 per 100 000 live births by 2030.
Key words: • Cesarean section • Maternal mortality • Fetal mortality • Spontaneous vaginal delivery • Trends in MMR • Nigeria

Copyright © 2020 Galadanci et al. This is an open-access article distributed under the terms of the Creative Com - mons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Characterization of Gemcitabine Loaded Polyhydroxybutyrate Coated Magnetic Nanoparticles for Targeted Drug Delivery
Authors: Parsian Maryam , Mutlu Pelin , Yalcin Serap , Gunduz Ufuk 
Published: March 2020

Background:
Targeted drug delivery is one of the recent hot topics in cancer therapy. Because of
having a targeting potential under the magnetic field and a suitable surface for the attachment of different therapeutic
moieties, magnetic nanoparticles are widely studied for their applications in medicine.

Objective:
Gemcitabine loaded polyhydroxybutyrate coated magnetic nanoparticles (Gem-PHB-MNPs) were
synthesized and characterized for the treatment of breast cancer by the targeted drug delivery method.

Methods:
The characterization of nanoparticles was confirmed by FTIR, XPS, TEM, and spectrophotometric
analyses. The cytotoxicities of drug-free nanoparticles and Gemcitabine loaded nanoparticles were determined
with cell proliferation assay using SKBR-3 and MCF-7 breast cancer cell lines.

Result:
The release of Gemcitabine from PHB-MNPs indicated a pH-dependent pattern, which is a desirable
release characteristic, since the pH of the tumor microenvironment and endosomal structures are acidic, while
bloodstream and healthy-tissues are neutral. Drug-free PHB-MNPs were not cytotoxic to the SKBR-3 and MCF-
7 cells, whereas the Gemcitabine loaded PHB-MNPs was about two-fold as cytotoxic with respect to free Gemcitabine.
In vitro targeting ability of PHB-MNPs was shown under the magnetic field.

Conclusion:
Considering these facts, we may suggest that these nanoparticles can be a promising candidate for
the development of a novel targeted drug delivery system for breast cancer.
Lauric Acid Modulates Cancer-Associated microRNA Expression and Inhibits the Growth of the Cancer Cell
Authors: Verma Poonam , Ghosh Amit , Ray Manisha , Sarkar Saurav 
Published: March 2020

Background:
microRNAs are known to regulate various protein-coding gene expression posttranscriptionally.
Fatty acids are cell membrane constituents and are also known to influence the biological
activities of the cells like signal transduction, growth and differentiation of the cells, apoptosis induction, and
other physiological functions. In our experiments, we used lauric acid to analyse its effects on human cancerous
cell lines.

Objective:
Our objective was to speculate the miRNA expression profile in lauric acid treated and untreated
cancerous cell lines and further study the metabolic pathways of the targeted tumour suppressor and oncogenes.

Methods:
The KB cells and HepG2 cells were treated with lauric acid and miRNA was isolated and the expression
of tumour suppressor and oncogenic miRNA was measured by quantitative PCR. The untreated cells were
used as control. The metabolic pathways of the target tumour suppressor and oncogenes were examined by
GeneMANIA software.

Results:
Interestingly, the lauric acid treatment suppresses the expression of oncogenic miRNA and significantly
upregulated the expression of some tumour suppressor miRNAs. GeneMANIA metabolic pathway revealed that
the upregulated tumour suppressor miRNAs regulate several cancer-associated pathways such as DNA damage,
signal transduction p53 class mediator, stem cell differentiation, cell growth, cell cycle phase transition, apoptotic
signalling pathway, cellular response to stress and radiation, etc. whereas oncogenic miRNAs regulate the
cancer-associated pathway like cell cycle phase transition, apoptotic signalling pathway, cell growth, response to
oxidative stress, immune response activating cell surface protein signalling pathway, cyclin-dependent protein
kinase activity, epidermal growth factor receptor signalling pathways, etc.

Conclusion:
In our study, we found that lauric acid works as an anticancer agent by altering the expression of
miRNAs.