bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective clinical trial of the effects produced by the extrusion arch in the treatment of anterior open bite
Authors: de Brito Vasconcelos Juliana , de Almeida-Pedrin Renata Rodrigues , Poleti Thais Maria Freire Fernandes , Oltramari Paula , de Castro Conti Ana Cláudia Ferreira , Bicheline Mirchel Henrique Bertola , Lindauer Steven J. , de Almeida Marcio Rodrigues 
Published: October 2020

Abstract
Aim
To evaluate the maxillary dentition effects of the extrusion arch for anterior open bite (AOB) correction in mixed dentition patients.

Materials and methods
Fourteen subjects with an initial mean age of 9.17 ± 1.03 years presenting with dentoalveolar AOB (mean − 1.28 ± 1.46 mm) and normal facial pattern (FMA = 25.76°) were treated with an extrusion arch. The mean treatment period was 7.79 ± 2.58 months. Lateral cephalograms and dental models were taken before (T0) and after the correction of AOB (T1). Data were analyzed using paired t test to evaluate differences between T0 and T1. For all tests, a significance level of P < .05 was used.

Results
All patients achieved positive overbite at T1, with a mean increase of 3.07 mm. The maxillary incisors extruded 1.94 mm. Retroclination of the maxillary incisors (− 6.15°) and an increase in the interincisal angle (5.57°) were observed. There was a significant decrease in the distance between the incisal edge of the maxillary incisors and the molars (− 2.21 mm). There was significant mesial tipping of the maxillary molar (− 11.49°). Significant reductions of overjet (− 1.65 mm), arch perimeter (− 3.02 mm), and arch length (− 2.23 mm) were noted. The transverse maxillary intermolar distance did not change significantly.

Conclusions
The use of a maxillary extrusion arch was effective in the treatment of AOB. Overbite increased due to incisor extrusion, as well as retroinclination and overjet reduction. However, side effects, such as mesial molar tipping and decreases in arch perimeter and length might occur.
Exploring the trends of educational virtual reality games: a systematic review of empirical studies
Authors: Oyelere Solomon Sunday , Bouali Nacir , Kaliisa Rogers , Obaido George , Yunusa Abdullahi Abubakar , Jimoh Ebunayo R. 
Published: October 2020

AbstractVirtual Reality (VR) and educational games are emerging technologies mediating a rapid transformation in the educational world. However, few studies have systematically analyzed Educational Virtual Reality Games (EVRGs) and how they have been applied in educational settings. This study reviewed 31 articles published in high impact journals and educational conference proceedings to unravel thetechnological, pedagogical, and gaming characteristics of contemporaryEVRGs. The results show the predominance of Oculus Rift headsets and HTC Vive as the main technology used in EVRGs. Moreover, the analysis revealed that the pedagogical application of the majority of EVRGs was developed for all levels of education (e.g. tertiary, K-12, lifelong learning), with the specific target audience of each game based on the desired learning outcome. Furthermore, the application of EVRGs has primarily focused on out of class use, with healthcare education topics dominating the topics taught using EVRGs. Based on our findings, we highlight some key implications and suggestions to advance the field of EVRGs.
The usage of Mate Select, a web-based selection tool for pedigree dogs for promoting sustainable breeding
Authors: Janes Mateja , Lewis Thomas W. , Ilska Joanna J. , Woolliams John A. 
Published: October 2020

AbstractBackgroundInbreeding is a phenomenon that accumulates through the mating of relatives within closed populations, such as pedigree dog breeds, and results in reduced genetic variation within breeds, and may lead to poorer health and fertility from inbreeding depression. The impact of inbreeding is driven by the selection and mating of parents, but information on choices to reduce inbreeding is difficult to assess for individual breeders. Tools to inform dog breeders on the current state of the inbreeding and the relationships among possible parents are potentially useful for providing guidance towards choices that are more beneficial to the breed. However, their utility depends on their usage and this study examines the usage of Mate Select, a web-based tool offered by The Kennel Club, covering 222 breeds for a period of 7 years following its launch in 2011.ResultsThe average usage was 2830 searches/week in 2012 with a slight fall of 2.2% per year (P < 0.001) to 2480 searches/week in 2018. Of these, 4% originated from outside the UK, across all continents except Antarctica, with the majority coming from English speaking countries. Searches/week showed a cyclical pattern with two cycles of 26.0 and 50.1 weeks. Since Mate Select’s launch there has been a steady increase in searches from mobile devices, from 11% in 2012 to 43% in 2018. For the 197 breeds with at least 10 dams registered with the Kennel Club during the study period, there was a relationship between usage and registrations, with the average number of searches as a multiple of the number of dams increasing from 2 to 10 for breeds with up to 70 dams and declining towards 2 again for the largest breeds with approximately 20,000 registered dams. However, there remained substantial variation among breeds of similar size, and breeds for which EBVs had become available during the study period had a 2.46 fold greater frequency of searches per registered bitch (P < 0.001), but this was not linked directly to the publication of EBVs.ConclusionsMate Select has sustained and substantial usage, although there is also substantial variation in usage among breeds, which offers an opportunity to develop further guidance.
Half-graben inversion tectonics revealed by gravity modeling in the Mikawa Bay Region, Central Japan
Authors: Miyakawa Ayumu , Abe Tomoya , Sumita Tatsuya , Otsubo Makoto 
Published: October 2020

AbstractThe Mikawa Bay Region, central Japan, is characterized by many active faults recording Quaternary activities. It is, however, difficult to understand the overall tectonic character of the region due to a thick sedimentary cover. We report the first finding of Neogene basin inversion in southwest Japan by estimating the depth and structure of the basement surface in the Mikawa Bay Region by analyzing gravity data. Our gravity basement map and two-dimensional density-structure model automatically determined using the genetic algorithm revealed a half-graben bounded on the south by the north-dipping Utsumi Fault. The motion of the Utsumi Fault, which inverted from normal faulting during the Miocene to recent reverse faulting, indicated the inversion of the half-graben. The timing of the inversion of the fault motion, i.e., the reverse faulting of the Miocene normal fault, can be compared with an episode of basin inversion observed at the eastern margin of the Japan Sea, northeastern Japan. The Takahama Fault in the southwestern part of the Nishi–Mikawa Plain is considered to have formed as a result of the backthrust of the Utsumi Fault under inversion tectonics. If the Takahama Fault is indeed the backthrust fault of the Utsumi Fault, the root of the Takahama Fault may be deep such that the Takahama Fault is seismogenic and linked to the 1945 Mikawa earthquake.
Recurrent gastric cancer sustaining a partial response after the nivolumab discontinuation because of immune-related adverse events: a case report
Authors: Arigami Takaaki , Matsushita Daisuke , Okubo Keishi , Tanaka Takako , Sasaki Ken , Noda Masahiro , Kita Yoshiaki , Mori Shinichiro , Tsuruda Yusuke , Kurahara Hiroshi , Ohtsuka Takao 
Published: October 2020

Abstract
Background
The prognosis of patients with recurrent gastric cancer is poor despite chemotherapy being clinically recommended as the first therapeutic strategy. Recent clinical trials have established the clinical utility of nivolumab in the third-line treatment of such patients. Immune-related adverse events (irAE) have been focused as a promising predictor for tumor response to nivolumab. This report aims to present a long-term survivor of recurrent gastric cancer who was followed up without any treatments after the nivolumab discontinuation because of irAE.

Case presentation
A 65-year-old male with stage III gastric cancer (cT4aN1M0) underwent surgery after neoadjuvant chemotherapy. Owing to the final pathological stage IIIB (ypT4bN1M0), the patient received adjuvant chemotherapy. Nevertheless, during adjuvant chemotherapy 1-year post-surgery, computed tomography (CT) revealed lymph node swelling in station no. 9. Thus, upon diagnosis with lymph node recurrence, the patient was treated with two courses of capecitabine + oxaliplatin and three courses of ramucirumab + paclitaxel as the first- and second-line regimens, respectively. Based on these regimens, the patient had a progressive disease to chemotherapy. Consequently, we administered nivolumab as the third-line regimen. After four courses of nivolumab, CT revealed a significant shrinkage of the metastatic lymph node, with a 45.6% reduction. We confirmed a partial response during 11 courses of nivolumab. Since the occurrence of grade 4 diabetes mellitus after 12 courses of nivolumab, the patient was followed up without any treatment after the nivolumab discontinuation. Currently, the patient remains a partial response for 15 months, since the nivolumab discontinuation and is alive for 31 months after disease recurrence.

Conclusions
Acute irAE during nivolumab chemotherapy could be one of the crucial clinical factors to predict tumor suppression in patients with advanced gastric cancer.
A community feasibility study of a cooking behavior intervention in African-American adults at risk for cardiovascular disease: DC COOKS (DC Community Organizing for Optimal culinary Knowledge Study) with Heart
Authors: Farmer Nicole , Powell-Wiley Tiffany M. , Middleton Kimberly R. , Roberson Brenda , Flynn Sharon , Brooks Alyssa T. , Kazmi Narjis , Mitchell Valerie , Collins Billy , Hingst Rachel , Swan Lucy , Yang Shanna , Kakar Seema , Harlan Timothy , Wallen Gwenyth R. 
Published: October 2020

AbstractBackgroundCooking interventions have increased in popularity in recent years. Evaluation by meta-analyses and systematic reviews show consistent changes in dietary quality reports and cooking confidence, but not of cardiovascular (CVD) biomarkers. Interventions evaluating or reporting behavioral mechanisms as an explanatory factor for these outcomes has been sparse. Moreover, evaluations of cooking interventions among communities with health disparities or food access limitations have received little attention in the literature.MethodsThis study will occur over two phases. Phase 1 will assess acceptability among the target population of African-American adults living within an urban food desert. Phase 2 will consist of a 6-week cooking intervention delivered at a community kitchen setting. Pre and post intervention visits for clinical examinations and biomarker collection will be conducted, as well as dietary and cooking skill assessments. Primary outcomes include cooking behavior and feasibility measures. Secondary outcomes are related to dietary quality, psychosocial factors, CVD biomarkers, and food environment measures.DiscussionThis study seeks to demonstrate feasibility of a community-based cooking intervention and to provide necessary information to plan future interventions that identify cooking behavior as an outcome of participation in cooking interventions among African-American adults, especially in relation to dietary and biomarker outcomes.Trial registrationThis study was registered atClinicalTrials.gov(NCT04305431) on March 12, 2020.
Spinal anesthesia for muscle biopsy in an infant with a suspected neuromuscular disorder: a case report
Authors: Ishida Yoshiaki , Morita Masato , Sasaki Takahisa , Taniguchi Akiko 
Published: October 2020

Abstract
Background
Neuromuscular disorders (NMDs) occur in different forms and are generally diagnosed using muscle biopsy. Among the available anesthetic management options for infants with a suspected NMD are general anesthesia (GA) and regional anesthesia (RA), including spinal anesthesia (SA). Anesthesia selection is often challenging from the point of potential airway risks and anesthetic drug-related complications.

Case presentation
A 6-month-old male infant repeatedly underwent endotracheal intubation and extubation after birth because of respiratory muscle weakness and copious secretions. He was suspected of having NMD and was scheduled for muscle biopsy. His generalized hypotonia and decreased respiratory function presented a potentially difficult airway and complicated the selection of an appropriate anesthetic method. We selected SA and dexmedetomidine, which are safe for infants.

Conclusion
We report the successful and effective anesthetic management of SA and dexmedetomidine in an infant with a suspected NMD.
The validity of astrological predictions on marriage and divorce: a longitudinal analysis of Swedish register data
Authors: Helgertz Jonas , Scott Kirk 
Published: October 2020

AbstractThis paper examines astrology, a concept that is considered unscientific by broad segments of the population in the western world. Despite this, astrology remains for some an important source for advice regarding choices in a range of different matters, including career and relationships. The continuing popularity of astrology may at least partly be linked to an insufficient body of empirical research that has been able to test hypotheses formulated by astrological theory, both due to a lack of data beyond very small study populations as well as astrological predictions frequently being vague and thereby difficult to test. This article examines how differences in astrological favorability influence partner choice in marriage as well as the divorce risk among married couples using longitudinal individual-level data from Sweden over the period 1968-2001. The results fail to provide any consistent evidence to support the notion that astrologically more compatible couples are either overrepresented among observed marital unions or associated with a lower risk of divorce.
A mixed-methods evaluation of a group based trail walking program to reduce anxiety in cancer survivors
Authors: Lesser I. A. , Prystupa J. , Belanger L. , Thomson C. , Nienhuis C. P. 
Published: October 2020

Abstract
Background
Cancer survivorship results in an increased number of physical and psychosocial health issues. Engaging in physical activity in natural environments is often thought of as restorative. Despite the potential benefits of engaging in physical activity in natural environments there are no sustainable community-based programs for cancer survivors that employ this form of physical activity. This study aims to evaluate the impact of an 8-week trail-walking (TW) program on anxiety in a population of adult cancer survivors.

Methods
The TW program consisted of two trail walks per week for 8 weeks led by a hiking guide. Individuals were eligible to participate if they were 19 years or older, were a cancer survivor, were not on active immunotherapy, and had medical clearance from their physician for physical activity. While 12 participants signed up for the program, 9 participants (N = 9, 8 F, 1 M) completed the program. A mixed methodology included pre-and-post quantitative program surveys and post-program interviews. Questionnaires measured generalized anxiety, sleep disturbances, self-efficacy, self-esteem, psychological well-being and depression as well as pre-and-post hike state anxiety. Data was analysed using paired t-tests. Interviews were transcribed verbatim and an inductive thematic analysis was conducted to consolidate meaning and identify themes using NVivo 11 software.

Results
Average attendance was 74% of the 16 hikes. There was no significant reduction in the primary outcome of generalized anxiety (p = .38). There was a significant reduction in perceived stress after 8-weeks (p = .03) and a significant reduction in state anxiety after TW (p < .001). None of the other secondary outcomes were statistically significant (p > .05). Four overarching themes, or benefits, emerged from qualitative data analysis: (a) benefits of program design (b) physical benefits, (c) psychological benefits, and (d) social benefits.

Conclusions
These findings demonstrate the utility of a TW program for cancer survivors in order to promote physical, psychological and social health. Feasibility of a TW program would be contingent on access to natural areas for TW and an instructor-led program with other cancer survivors.
Cardiovascular risk knowledge in patients of South Asian origin living with rheumatoid arthritis: data from India and the UK
Authors: Kumar Kanta , Arya Suvrat , Nightingale Peter , Sheeran Tom , Aggarwal Amita 
Published: October 2020

Abstract
Background
South Asians have a higher risk of cardiovascular disease (CVD). Rheumatoid arthritis (RA) increases the risk of premature atherosclerosis. We investigated whether there was a substantial difference in the level of CVD risk knowledge among patients of South Asian origin with RA in India and in the UK.

Methods
In this cross-sectional survey, patients of South Asian origin with RA from India and the UK were recruited from secondary care settings. Data were collected via Heart Disease Fact Questionnaire-Rheumatoid Arthritis (HDFQ-RA), a validated self-completion questionnaire. The HDFQ-RA was translated into Hindi and piloted among patients from South Asian background before use. Additionally, clinical and demographic data was collected.

Results
Among 118 patients from each country, 84% were female and they had similar age, education level, employment status and co-morbidities. Patients from India had longer disease duration (5.5 years versus 4.1 years (p = 0.012) whereas those from the UK had higher disease activity score (4.0 + 0.8 versus 3.1 + 0.7, p < 0.01). Regarding modifiable risk factors for CVD only 51.2% from India and 51.3% in the UK were aware of them. However, awareness of the link between RA and increased risk of CVD was even more limited (32.8% in India and 34.4% in UK).

Conclusion
Patients of South Asians origin with RA from both countries had limited knowledge about CVD risk. There is a need to educate them about CVD risk during consultation, as this will result in better outcomes.
Optimal rearing medium for the population growth of the predatory mite, Amblyseius swirskii (Athias-Henriot) (Acari: Phytoseiidae)
Authors: San Phyu Phyu , Tuda Midori , Nakahira Kengo , Takagi Masami 
Published: October 2020

Abstract
Background
The successful rearing of predators or parasitoids is one of the most important elements in biological control programs. The dried fruit mite, Carpoglyphus lactis (L.), can be used as an alternative prey for the phytoseiid predatory mite, Amblyseius swirs0kii (Athias-Henriot).

Main body
This study aimed to evaluate the suitability of 3 different diets for C. lactis when rearing A. swirskii: brown sugar, baker’s yeast, and the mixture of brown sugar and baker’s yeast along with 3 initial predator:prey ratios (1:7, 1:12, and 1:20). After 30 days, both the baker’s yeast and the mixture of brown sugar + baker’s yeast diets resulted in the highest predator densities (40.5 times increase at an initial predator:prey ratio of 1:20, with the baker’s yeast diet), whereas the mixture diet produced the highest density of prey. The brown sugar resulted in the lowest number of predator and prey mites. This may be due to lower feeding and predation rates of the prey and the predator mites on the brown sugar medium since its relative moisture content and adhesiveness inhibits mite movement. The final predator:prey ratio was also highest on the baker’s yeast diet.

Conclusions
This study demonstrated that the population growth of A. swirskii was the highest when C. lactis was reared on baker’s yeast.
Schizophrenic patients’ cognitive functions in relation to their metabolic profile: a cross-sectional, comparative study on an Egyptian sample
Authors: Ali Dalia Hegazy , Elserafi Doha Mostafa , Soltan Marwa Abdel Rahman , Eissa Mohamed Fikry , Zein Hanan Ahmed , Elshahawi Heba Hamed 
Published: October 2020

Abstract
Background
Patients with schizophrenia suffer from diffuse cognitive impairment and high prevalence of cardiovascular metabolic risks, associated with poor clinical outcomes. We aimed in this study to test the presence of cognitive impairment in a sample of patients with schizophrenia, and evaluate its possible relations to patients’ metabolic profile. We recruited forty patients diagnosed with schizophrenia and their matched controls from the inpatient departments and outpatient services from January to December 2016. Schizophrenia diagnosis was confirmed by the ICD10 criteria checklist. Symptoms profile and severity were assessed by the Positive and Negative Syndrome Scale. Cognitive profile was assessed through (1) Trail Making Test, Parts A and B and (2) Wechsler Memory Scale-Revised Visual Reproduction Test. Metabolic profile was assessed by measuring the body mass index, fasting blood glucose, and lipid profile. SPSS (V. 22.0, IBM Corp., USA, 2013) was used for data analysis.

Results
The patients group had a significantly higher means in the speed of processing, executive function, attention, and working memory scores on TMT-A (p = 0.0), TMT-B (p = 0.00), and WMS-R (p = 0.029) and significantly higher FBG levels (p = 0.00). Correlation studies showed that the increase in patients’ age, illness duration, treatments, number of hospitalizations, number of episodes and of ECT sessions received, symptoms severity, and deficits in cognitive function scores was associated with higher BMI and FBG.

Conclusions
Patients with schizophrenia have a higher prevalence of cognitive impairment and vascular risk factors than the general population. Close monitoring and early management of these risk factors can promote better cognitive abilities and overall functions.