bluuebunny/crossref_metadata_2025_split huggingface dataset:
Great significance of innovative research on capital for building socialist political economics with Chinese characteristics
Authors: Qiu Haiping 
Published: December 2020

PurposeGeneral Secretary Xi Jinping pointed out that to uphold and develop socialist political economics with Chinese characteristics, the authors should be guided by Marxist political economics.Design/methodology/approachIt is an essential methodological principle for building a theoretical system of socialist political economics with Chinese characteristics as a “systematic economic theory”.FindingsTo implement this principle, the authors need to understand the rich connotation of Marxist political economics and its relationship with socialist political economics with Chinese characteristics fully and correctly and unswervingly uphold and inherit, creatively transform and innovatively develop the theoretical achievements of Marxist economics, especially capital.Originality/valueIt is also an essential and necessary way to build a theoretical system of socialist political economics with Chinese characteristics.
Investigation of spatial configuration management on social distancing of recreational clubhouse for COVID-19 in Penang, Malaysia
Authors: Abdul Nasir Nur Adibah Binti , Hassan Ahmad Sanusi , Khozaei Fatemeh , Abdul Nasir Muhammad Hafeez Bin 
Published: December 2020

PurposeSince the appearance of COVID-19 social distancing and staying home have been recommended repeatedly by the governments for disease prevention. As the challenge continues to remain the current study seeks to examine the factors affecting social distancing through space planning and management. More specifically the current study aims to examine the appropriateness of the spatial organization and space configuration of a clubhouse with a linear plan layout in the mitigation of the spread of infections due to serious pandemic COVID-19.Design/methodology/approachFor an enhanced understanding of the impact of spatial arrangements of public spaces plan on the effective implementation of social distancing this study has used the space syntax analysis method. The MPSP clubhouse building in Penang, Malaysia was selected as the case study. The level of permeability and wayfinding were determined in the building plan and were illustrated using photoshop software to depict the interrelation between the indoor spaces and building circulation. Graphs of the depth of space were used to analyze the level of permeability and wayfinding to illustrate the possibility of social distancing in the plan.FindingsThe result of the study shows the significant role of proper plan layout design on social distancing. While clear and direct wayfinding can positively be associated with more effective social distancing, the inefficient design of user access, inappropriate locations of multiple entry and exit and indefinite directions of users' inside buildings can impose slight limitations. The average level of permeability might suggest ineffective spatial arrangement, ignoring the needs of spatial segregation. The study further found that the linear plan layouts with proper zoning and effective management strategies can be considered a proper layout to facilitate social distancing and the spread of COVID-19.Originality/valueThe current study is unique in terms of examination of the spatial configuration of linear public spaces plan layout for possible temporary adaptability to curb disease spread during the unexpected advent of a pandemic. Based on researchers' best of knowledge it is the first time that the impact of recreational space design on social distancing has been examined. The study also originally sheds light on the fact that the commonly used guideline for the social distancing of 1–2 m between 2 persons, in reality, is practically inadequate given the nature of the sports activities.
Forecasting vehicle's spare parts price and demand
Authors: Alalawin Abdallah , Arabiyat Laith Mubarak , Alalaween Wafa , Qamar Ahmad , Mukattash Adnan 
Published: December 2020

PurposeThese days vehicles' spare parts (SPs) are a very big market, and there is a very high demand for these parts. Forecasting vehicles' SPs price and demand are difficult because of the lack of data and the pricing of the SPs is not following the normal value chain methods like normal products.Design/methodology/approachA proposed model using multiple linear regression was developed as a guide to forecasting demand and price for vehicles' SPs. A case study of selected hybrid vehicle is held to validate the results of the research. This research is an original study depending on quantitative and qualitative methods; some factors are generated from realistic data or are calculated using numerical equations and the analytic hierarchy process (AHP) method; online questionnaire and expert interview survey.FindingsThe price and demand for SPs have a linear relationship with some independent variables is the hypothesis that is tested. Even though the proposed models are generally recommended for predicting demand and price, in this research the linear relationship models are not significant enough to calculate the expected price and demand.Originality/valueThis research should concern both academics and practitioners since it provides new intuitions on the distinctions between scientific and industrial world regarding SPs for vehicles as it is the first study that investigates price and demand of vehicles' SPs.
Mapping QTL controlling soybean seed sucrose and oligosaccharides in a single family of soybean nested association mapping (SoyNAM) population
Authors: Salari Mohammad Wali , Ongom Patrick Obia , Thapa Rima , Nguyen Henry T. , Vuong Tri D. , Rainey Katy Martin 
Published: December 2020

AbstractThe meal value of Soybean for monogastric animals is determined partly by sucrose, raffinose and stachyose. Of these, sucrose is desirable, while raffinose and stachyose are indigestible, causing flatulence and abdominal discomfort. The objective of this study was to identify quantitative trait loci (QTL) controlling seed sucrose, raffinose, and stachyose in a set of 140 SoyNAM (Nested Association Mapping) recombinant inbred lines (RILs), developed from the cross between lines IA3023 and LD02‐4485. A total of 3,038 SNP markers from the Illumina SoyNAM BeadChip SNP were used to map the QTLs for sucrose and the RFOs, raffinose, and stachyose. Significant genotypic differences (p < .001) among RILs were observed for sucrose, raffinose and stachyose contents across years. A 3038 Illumina SoyNAM BeadChip SNPs identified three QTLs for sucrose, one on chromosome 1, explaining 10% variance and two on chromosome 3 each explaining 22%. Raffinose QTL was detected on chromosome 6, explaining 6% variance. The mapped QTLs were novel and spanned regions harbouring candidate genes with roles in plant growth including seed development.
A New Approach to Modeling Slip and Work Input for Centrifugal Compressors
Authors: Harrison Herbert M. , Key Nicole L. 
Published: December 2020

Abstract
A new method of modeling slip factor and work input for centrifugal compressor impellers is presented. Rather than using geometry to predict the behavior of the flow at the impeller exit, the new method leverages governing relationships to predict the work input delivered by the impeller with dimensionless design parameters. The approach incorporates both impeller geometry and flow conditions and, therefore, is inherently able to predict the slip factor both at design and off-design conditions. Five impeller cases are used to demonstrate the efficacy of the method, four of which are well documented in the open literature. Multiple implementations of the model are introduced to enable users to customize the model to specific applications. Significant improvement in the accuracy of the prediction of slip factor and work input is obtained at both design and off-design conditions relative to Wiesner's slip model. While Wiesner's model predicts the slip factor of 52% of the data within ±0.05 absolute error, the most accurate implementation of the new model predicts 99% of the data within the same error band. The effects of external losses on the model are considered, and the new model is fairly insensitive to the effects of external losses. Finally, detailed procedures to incorporate the new model into a meanline analysis tool are provided in the appendices.
Heat Exchanger Design Optimization for Mitigation of Diesel Engine Exhaust Fouling
Authors: Aiello Victor C. , Kini Girish , Staedter Marcel A. , Garimella Srinivas 
Published: December 2020

Abstract
The design optimization of a diesel exhaust-coupled heat and mass exchanger that drives a 2.71 kW cooling capacity absorption heat pump is presented in this study. Fouling layer thermal resistance and pressure drops from single-tube experiments are used to develop a thermodynamic, heat transfer, and pressure drop model for the exhaust-coupled desorber. A parametric study is performed to select a desorber design that meets system performance while minimizing footprint. Experimental heat duties and pressure drops are within 10% and 3%, respectively, of the model predictions. Thus, large data sets from single-tube experiments with representative geometries are successful in accounting for fouling effects at the component level. Desorber design optimization based on this approach ensures continued heat pump performance after fouling. This study, along with the single-tube experiments, presents a systematic approach to design exhaust-coupled heat exchangers while considering the effects of fouling. These results are applicable for a wide range of waste-heat recovery applications, and this method can be extended to different geometries and operating conditions.
Positron Emission Tomography Combined With Computed Tomography vs. No Positron Emission Tomography Combined With Computed Tomography for the Management of Patients With Resectable Colorectal Cancer Liver Metastases and Synchronous Extrahepatic Disease
Authors: Serrano Pablo E. , Gu Chu-Shu , Moulton Carol-Anne , Gallinger Steven 
Published: December 2020

Introduction Selected patients with colorectal cancer liver metastases (CRLM) and synchronous extrahepatic disease (EHD) are considered for surgery. Objectives To evaluate the change in surgical management and long-term survival (disease-free survival [DFS] and overall survival [OS]) for patients with CRLM and EHD who undergo positron emission tomography combined with computed tomography (PET-CT) vs no PET-CT. Methods Patients with CRLM were enrolled in a trial evaluating the effect of PET-CT (vs no PET-CT) on surgical management, DFS, and OS. This is a sub-study of the trial, including only patients with synchronous EHD. Cox proportional hazard models were used to calculate risks for recurrence and death. Survival were described by Kaplan-Meier method and compared with log-rank test. Results Of 25 patients with EHD (PET-CT arm: 14/270 (5%) and no PET-CT arm: 11/134 (8%)), PET-CT changed surgical management in 14%, all of which avoided liver resection due to more extensive disease. Complete metastasectomy was achieved in 36% (5/14) and 72% (8/11), respectively. Respectively, PET-CT vs no PET-CT had statistically similar median DFS, 5.6 months (95% confidence interval (CI) 3.6-18) vs 7.6 months (95% CI 2.9-15) and median OS, 42 months (95% CI 25-48) vs 29 months (95% CI 17-41). EHD was associated with worse DFS (hazard ratio HR = 1.89, 95% CI 1.41-2.52) and OS (HR = 2.47, 95% CI 1.6-3.83). Conclusions Preoperative PET-CT for the management of resectable CRLM did not improve long-term outcomes among patients who had synchronous EHD; however, it changed surgical management in a relatively significant proportion of patients.
Evaluation of Ion Torrent next-generation sequencing for thalassemia diagnosis
Authors: Chen Peisong , Yu Xuegao , Huang Hao , Zeng Wentao , He Xiaohong , Liu Min , Huang Bin 
Published: December 2020

Introduction To evaluate a next-generation sequencing (NGS) workflow in the screening and diagnosis of thalassemia. Methods In this prospective study, blood samples were obtained from people undergoing genetic screening for thalassemia at our centre in Guangzhou, China. Genomic DNA was polymerase chain reaction (PCR)-amplified and sequenced using the Ion Torrent system and results compared with traditional genetic analyses. Results Of the 359 subjects, 148 (41%) were confirmed to have thalassemia. Variant detection identified 35 different types including the most common. Identification of the mutational sites by NGS were consistent with those identified by Sanger sequencing and Gap-PCR. The sensitivity and specificities of the Ion Torrent NGS were 100%. In a separate test of 16 samples, results were consistent when repeated ten times. Conclusion Our NGS workflow based on the Ion Torrent sequencer was successful in the detection of large deletions and non-deletional defects in thalassemia with high accuracy and repeatability.
Pathogenesis, Evaluation, and Management of Osteolysis Following Total Ankle Arthroplasty
Authors: Mehta Nabil , Serino Joseph , Hur Edward S. , Smith Shelby , Hamid Kamran S. , Lee Simon , Bohl Daniel D. 
Published: December 2020

Periprosthetic osteolysis is a common occurrence after total ankle arthroplasty (TAA) and poses many challenges for the foot and ankle surgeon. Osteolysis may be asymptomatic and remain benign, or it may lead to component instability and require revision or arthrodesis. In this article, we present a current and comprehensive review of osteolysis in TAA with illustrative cases. We examine the basic science principles behind the etiology of osteolysis, discuss the workup of a patient with suspected osteolysis, and present a review of the evidence of various management strategies, including grafting of cysts, revision TAA, and arthrodesis. Level of Evidence: Level V, expert opinion.
Comparison of Autogenous Block Bone Graft and Screw Tent-Pole Techniques for Vertical Bone Augmentation in the Posterior Mandible: A Split-Mouth Randomized Controlled Study
Authors: Işık Gözde , Günbay Tayfun , Uyanıkgil Yig˘it , Kısaog˘lu Hüseyin , Yüce Meltem Özden 
Published: December 2020

Aim: To evaluate the effect on vertical bone augmentation of the screw tent-pole technique using particulate allograft in combination with injectable platelet-rich fibrin, and to compare this with autogenous block bone graft. Materials and Methods: This split-mouth randomized controlled study involved patients with bilateral partial edentulism and vertical bone loss in the posterior mandible. In each patient, the control side was treated with autogenous block bone graft harvested from the mandibular ramus and, on the test side, the screw tent-pole technique was employed, using particulate allograft in combination with injectable platelet-rich fibrin. All augmented sites were covered by leukocyte and platelet-rich fibrin membrane. The primary outcome variable of this study was the radiographic changes to bone height 6 months after augmentation. The secondary outcome variables were the percentage of newly formed bone and the implant survival rate. The data were analyzed with a significance level of α = 0.05. Results: Of the 13 patients included, a total of 11 patients (7 females, 4 males; mean age 50.92) completed the study. The mean values of vertical bone gain were 1.72 ± 0.78 mm for the test group and 2.83 ± 0.89 mm for the control group, which constitutes a significant difference ( P = .008). The percentage of newly formed bone was 18.08% ± 2.17% for the test group and 14.26% ± 1.76% for the control group. The difference between the groups was statistically significant ( P < .001). The implant survival rates were 100% for both study groups. Conclusions: Based on the study results, screw tent-pole can be considered a feasible technique for bone augmentation. Further randomized studies will be necessary to fully evaluate vertical bone augmentation using the screw tent-pole technique, with different graft materials and with larger samples.
Remineralization Potential and Shear Bond Strength of Surface Treated Hypomineralized Enamel in Bonding of Orthodontic Brackets: An In Vitro Study
Authors: Enan EnasTawfik , Tawfik Marwa Ali , Mehesen Rabab , Basha Sakeenabi 
Published: December 2020

Aim: To investigate the effect of different conditioning methods on remineralization potential of hypomineralized enamel and its shear bond strength (SBS) to orthodontic brackets. Materials and Methods: An in vitro study was conducted at Mansoura University, Egypt. Eighty premolars were collected and randomly classified into four groups ( n = 20 each) as follows: Group 1. Control (sound teeth), Group 2. Demineralized, Group 3. Demineralized and treated with nanohydroxyapatite (nano-HA) varnish, Group 4. Demineralized and treated with casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) paste. To detect the rate of remineralization on the surface of treated specimens, energy dispersive X-ray (EDX) analysis was used in conjunction with the scanning electron microscope (SEM). The SBS was measured with a universal testing machine. One-way ANOVA test was carried out to analyze differences between the tested groups. Result: SE micrographs of Group 3 and Group 4 specimens showed smoother and less porous enamel surface than that of the Group 2 specimens. EDX analysis showed highest calcium (Ca) (25.47%) and phosphorous (P) (12.76%) values for Group 4 while Group 2 showed the lowest Ca and P values (16.96%) and (10.20%), respectively ( P < .001). Demineralized enamel showed lowest (3.70 MPa) SBS mean value compared to sound (10.69 MPa) and remineralized enamel (Group 3—9.90 MPa, Group 4—10.32 MPa) ( P < .001). Conclusion: Nano-HA and CPP–ACP have equal remineralizing effect on hypomineralized enamel lesions and positive influence on SBS.
Perinatal Asphyxia Among Neonates Admitted Jimma Medical Center, Jimma, Ethiopia
Authors: Kebede Ebissa Bayana , Akuma Adugna Olani , Tarfa Yonas Biratu 
Published: December 2020

Background: Perinatal asphyxia is a severe problem which causes serious problem in neonates in developing countries. This study is aimed to determine magnitude of perinatal asphyxia and its associated factors. Methods: A cross-sectional study design was conducted among neonates admitted over a period of 4 years on 740 samples. Systematic sampling method was employed to get required samples from log book. Epi-data 3.1 is used for data entry and the entered data was exported to SPSS Version 23 for analysis. Bivariable and multiple variable logistic regressions analysis were applied to see the association between dependent and independent variables. Finally, P-value <.05 at 95% CI was declared statistically significant. Results: The main significant factor associated to perinatal asphyxia were prolonged labor ( P = .04, AOR = 1.68 95%CI: [1.00, 2.80]), being primipara ( P = .003, AOR = 2.06, 95%CI: [1.28, 3.30]), Small for Gestational Age (SGA) ( P = .001, AOR = 4.35, 95%CI: [1.85, 10.19]), Large for Gestational Age ( P = .001, AOR = 16.75, 95%CI: [3.82, 73.33]) and mode of delivery. Conclusion: The magnitude of perinatal asphyxia was 18%. Prolonged labor, parity, birth size, mode of delivery, and APGAR score at 1st minute were significantly associated with perinatal asphyxia. So, Nurses, Midwives, Medical Doctors, and health extension workers have to engage and contribute to on how to decrease the magnitude of perinatal asphyxia.
Predicting substitutions to modulate disorder and stability in coiled-coils
Authors: Karami Yasaman , Saighi Paul , Vanderhaegen Rémy , Gerlier Denis , Longhi Sonia , Laine Elodie , Carbone Alessandra 
Published: December 2020

Abstract
Background
Coiled-coils are described as stable structural motifs, where two or more helices wind around each other. However, coiled-coils are associated with local mobility and intrinsic disorder. Intrinsically disordered regions in proteins are characterized by lack of stable secondary and tertiary structure under physiological conditions in vitro. They are increasingly recognized as important for protein function. However, characterizing their behaviour in solution and determining precisely the extent of disorder of a protein region remains challenging, both experimentally and computationally.

Results
In this work, we propose a computational framework to quantify the extent of disorder within a coiled-coil in solution and to help design substitutions modulating such disorder. Our method relies on the analysis of conformational ensembles generated by relatively short all-atom Molecular Dynamics (MD) simulations. We apply it to the phosphoprotein multimerisation domains (PMD) of Measles virus (MeV) and Nipah virus (NiV), both forming tetrameric left-handed coiled-coils. We show that our method can help quantify the extent of disorder of the C-terminus region of MeV and NiV PMDs from MD simulations of a few tens of nanoseconds, and without requiring an extensive exploration of the conformational space. Moreover, this study provided a conceptual framework for the rational design of substitutions aimed at modulating the stability of the coiled-coils. By assessing the impact of four substitutions known to destabilize coiled-coils, we derive a set of rules to control MeV PMD structural stability and cohesiveness. We therefore design two contrasting substitutions, one increasing the stability of the tetramer and the other increasing its flexibility.

Conclusions
Our method can be considered as a platform to reason about how to design substitutions aimed at regulating flexibility and stability.
A2A: a platform for research in biomedical literature search
Authors: Rybinski Maciej , Karimi Sarvnaz , Nguyen Vincent , Paris Cecile 
Published: December 2020

AbstractBackgroundFinding relevant literature is crucial for many biomedical research activities and in the practice of evidence-based medicine. Search engines such as PubMed provide a means to search and retrieve published literature, given a query. However, they are limited in how users can control the processing of queries and articles—or as we call themdocuments—by the search engine. To give this control to both biomedical researchers and computer scientists working in biomedical information retrieval, we introduce a public online tool for searching over biomedical literature. Our setup is guided by the NIST setup of the relevant TREC evaluation tasks in genomics, clinical decision support, and precision medicine.ResultsTo provide benchmark results for some of the most common biomedical information retrieval strategies, such as querying MeSH subject headings with a specific weight or querying over the title of the articles only, we present our evaluations on public datasets. Our experiments report well-known information retrieval metrics such as precision at a cutoff of ranked documents.ConclusionsWe introduce the search andbenchmarkingtool which is publicly available for the researchers who want to explore different search strategies over published biomedical literature. We outline several query formulation strategies and present their evaluations with known human judgements for a large pool of topics, from genomics to precision medicine.