bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypic and genotypic analysis of SERPINA12‐related autosomal recessive palmoplantar keratoderma in southwestern China
Authors: Li Zhongtao , Xie Shengyu , Xu Xueqin , Chen Zhiming , Wang Long , Yang Yuan , Wang Sheng 
Published: December 2024

AbstractHereditary palmoplantar keratoderma (hPPK) comprises a clinical and heterogeneous group of skin disorders characterized by hyperkeratosis of the palms and soles. Variants of SERPINA12 have been implicated in autosomal recessive diffuse hPPK, which shares similarities with Nagashima‐type PPK due to biallelic variants in SERPINB7. To date, seven SERPINA12 variants have been found in 11 patients with biallelic SERPINA12 variants worldwide. Herein, we described six new cases of hPPK caused by biallelic SERPINA12 variants from southwestern China. Our study showed commonly extensive distribution of skin lesions and various comorbidities in patients with SERPINA12‐related hPPK. Moreover, we revealed the variant c.635‐7A>G was a founder variant in patients with SERPINA12‐related hPPK in southwestern China. Our work is helpful to improve the knowledge of clinical and genetic characteristics of SERPINA12‐related hPPK.
Impact of long‐term mass‐rearing on the genetic structure of tsetse fly Glossina palpalis gambiensis colonies
Authors: Dera Kiswend‐sida M. , Pagabeleguem Soumaïla , Melachio Tanekou Tito Tresor , Toé Ange Irénée , Ouedraogo/Sanou Gisèle Marie Sophie , Belem Adrien Marie Gaston , Ravel Sophie , Mach Robert L. , Vreysen Marc J. B. , Abd‐Alla Adly M.M. 
Published: December 2024

AbstractTsetse flies are the sole cyclic vectors of African trypanosomes, which cause human and animal African trypanosomiases in Africa. Tsetse fly control remains a promising option for disease management. The sterile insect technique (SIT) stands as an environmentally friendly tool to control tsetse populations. SIT requires the mass‐rearing of competent sterile males to mate with wild females. However, long‐term colonization might affect the genetic structure of the reared flies. This study investigated the genetic structure of four Glossina palpalis gambiensis colonies of different ages: two originating from Senegal (SEN and ICIRSEN) and two from Burkina Faso (CIR and IBD). Samples from these colonies were genotyped at ten microsatellite loci, followed by downstream population genetic analyses. The results show that the two colonies from Burkina Faso collected from close sites (∼20 km apart) over 45‐year interval retained the same genetic background (FST_CIR∼IBD ≈ 0, P‐value = 0.47). These flies were however, genetically different from those from the Senegal colonies (FST_CIR∼SEN ≈ 0.047; FST_IBD∼SEN ≈ 0.058, P‐value = 10−4). Moreover, no significant difference was detected in the gene diversity of the CIR and IBD colonies, with HS values of 0.650 and 0.665, respectively. The inbreeding coefficient showed that all four colonies where under Hardy–Weinberg equilibrium, with FIS values of 0.026, 0.012, −0.064, and 0.001, for CIR, IBD, ICIRSEN, and SEN, respectively. Furthermore, no sign of a recent bottleneck was identified in tsetse samples from any of the four colonies. The results suggest that long‐term mass‐rearing of tsetse flies has no significant impact on their genetic background and diversity.
The token undermining effect: When and why adding a small reward to a dated outcome makes it less preferred
Authors: Jiang Cheng‐Ming , Chen Li‐Na , Luo Qian , Wang Wen , Zhou Jing , Ma Jia‐Tao 
Published: December 2024

AbstractThe mere token strategy, which adds a small reward (token) to an option to increase attractiveness, is widely used in the consumer field. However, we conducted six studies that seek to confirm the ‘token undermining effect’, where adding a small token to a sooner and smaller reward (SS) paired with a later and larger reward (LL) decreases the preference for the SS. The results showed that the effect persists across various choice sets, participant populations, reward amounts, delays, outcome properties and regardless of whether the scenarios are incentivized. However, an important boundary condition was that the token must share the same nature as the original option. Furthermore, we used mouse cursor tracking methods to examine the underlying process of attention allocation and demonstrated that adding a small token to the SS leads individuals to allocate more attention to the magnitude dimension than to the delay dimension, ultimately decreasing their preference for the SS. Therefore, managers and policymakers should use the mere token strategy with caution as it could backfire.
Positive well‐being and dampened emotional reactivity to daily family conflict and family cohesion
Authors: Rahal Danny , Fosco Gregory M. 
Published: December 2024

AbstractConflict and a lack of cohesive daily family relationships can negatively affect adolescent adjustment, although adolescents differ in how they respond (i.e., their emotional reactivity) to these daily experiences. The present study assessed whether adolescents' well‐being (i.e., life satisfaction, purpose) was associated with dampened emotional reactivity to daily variability in family conflict and cohesion. Adolescents (N = 150; MAge = 14.60, SD = 0.83; 61.3% female; 83.4% white) completed a questionnaire regarding well‐being and reported family conflict, cohesion, and negative emotion for 21 days between August 2015 and November 2016. Greater life satisfaction was related to dampened negative emotional reactivity to daily conflict, whereas greater purpose was related to dampened negative emotional reactivity to changes in daily family cohesion. Well‐being may foster resilience in adolescents' day‐to‐day emotional processes.
The Impact of Traumatic Dental Injury on the Oral Health‐Related Quality of Life of Preschool Children: A Cross‐Sectional Study
Authors: Zhang Li , Wang Xinmeng , Wang Yumin , Peng Jiahan , Huang Ruijie 
Published: December 2024

ABSTRACTBackground/AimThe aim of this study was to investigate the impact of traumatic dental injury (TDI) on oral health‐related quality of life (OHRQoL) of preschool children, and further inform public oral health care policies and strategies for this age group TDI patients.Materials and MethodsThis retrospective and cross‐sectional study was conducted in the Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China. It included 314 children aged from 2 to 5 years, with 90 children diagnosed with TDIs and 224 without TDIs. Parents or primary caregivers completed questionnaires, and the responses were gathered for statistical analysis to evaluate the impact of TDIs. The OHRQoL was assessed using the Early Childhood Oral Health Impact Scale (ECOHIS).ResultsThe total ECOHIS score and the scores for the 13 individual items were significantly higher in children with TDIs compared with those without TDI (p < 0.001). In the child impact section, eating and masticatory function were the most severely affected (40%), while most of parents experienced strong feelings of self‐blame in the family impact section (61.1%). A positive correlation was observed between the number of injured teeth and the total ECOHIS score (p = 0.001), while the time elapsed since TDI indicates a negative correlation with the total ECOHIS score (p < 0.001). Additionally, children with severe TDIs had higher ECOHIS scores than those with mild TDIs, indicating a greater impact on OHRQoL (p = 0.006). In contrast, tooth discoloration, the caregiver's relationship to the child, caregiver education level and the position of the affected teeth did not significantly influence the total ECOHIS score (p > 0.05).ConclusionsTDIs have a significant impact on OHRQoL in preschool children, highlighting the need for greater societal attention. Strengthening preventive and proper treatment measures for TDIs, along with enhancing health education programs, is strongly recommended.
Partial arytenoidectomy in 21 standing draught horses with recurrent laryngeal neuropathy
Authors: Gray S. M. , Gutierrez‐Nibeyro S. D. 
Published: December 2024

SummaryObjectiveTo report the use of standing partial arytenoidectomy (PA) in draught horses affected by left‐sided recurrent laryngeal neuropathy (RLN).Study designRetrospective descriptive study.AnimalsTwenty‐one draught horses diagnosed with left‐sided recurrent laryngeal neuropathy (RLN).MethodsMedical records of 21 draught horses subjected to standing PA to treat left‐sided RLN were reviewed. Data recorded included history, signalment, presenting complaint, athletic or intended use, pre‐ and postoperative resting upper respiratory tract endoscopic findings, perioperative medication, surgical details, postoperative exercise recommendations and follow‐up.ResultsTwenty‐one horses (100%) had a history of abnormal respiratory noise and 15 horses (71%) had exercise intolerance. Of the 19 horses with follow‐up, surgery resolved or significantly reduced the abnormal respiratory noise in 17 horses (90%) and resolved exercise intolerance in all 13 horses with a history of exercise intolerance and follow‐up. None of the horses had signs or evidence of coughing at the time of follow‐up.ConclusionStanding left‐sided PA can resolve the clinical signs associated with left‐sided RLN in draught horses.
On the Retention of Cod Early Life Stages Spawned at Jan Mayen
Authors: Frøysa Håvard G. , Bogstad Bjarte , Williams Tom , Stiansen Jan Erik 
Published: December 2024

ABSTRACTThe Jan Mayen shelf has recently been identified as a spawning area for cod (Gadus morhua). Genetic analyses and otolith types of adult cod caught in the Jan Mayen area show that they are of mixed origin, from both Iceland and the Barents Sea. However, they are genetically different from both stocks indicating the possibility of a cod stock around Jan Mayen. Motivated by this, we investigate the potential for eggs and larvae of cod to stay behind at Jan Mayen after spawning, which would be a requirement for having a self‐sustained stock. This is done using a numerical model for larval drift and growth, similarly to what has been done for other cod stocks. Using the modelled drift, we compare the proportion of larvae retained in different years to the strength of year classes as indicated by fisheries data. We find that even if most individuals are transported away from Jan Mayen, there are still some years where a significant proportion (more than 20%) of the larvae remains at the time of settlement in October–November. However, the year‐to‐year variability is large, with almost no individuals remaining in certain years. Our results suggest that aggregated over years, the amount of larvae that reach the age of bottom settlement on the Jan Mayen shelf area could be sufficient to give a potential for a self‐sustained cod population. In addition, we find that the main drift direction away from Jan Mayen is southwest towards East Greenland.
Quantitative color analysis of the diets of patients with metabolic dysfunction‐associated steatotic liver disease: Comparative study with nutritionally balanced diets
Authors: Yamazaki Asumi , Takachi Yuka , Takahashi Hirokazu , Hara Nagisa , Ogawa Yuji , Hyogo Hideyuki , Koseki Masahiro , Hayakawa Mariko , Nakajima Atsushi , Iwaki Michihiro , Fujii Makoto , Ishida Takayuki , Kamada Yoshihiro ,   Japan Study Group of NAFLD (JSG‐NAFLD)
Published: December 2024

AbstractAimThe prevalence of metabolic dysfunction‐associated steatotic liver disease (MASLD), including its severe subtype, metabolic dysfunction‐associated steatohepatitis (MASH), is increasing worldwide. This condition is a major health concern as MASH can progress to cirrhosis and hepatocellular carcinoma. With no specific medications available, lifestyle modifications, particularly dietary and exercise interventions, are crucial for managing MASLD. This study aimed to analyze the color characteristics of meals consumed by MASLD patients, seeking insights for dietary modifications.MethodsWe quantitatively analyzed the chromaticity, hue, and chroma of photographs of patients' meals and compared these statistical measures with those of nutritionally balanced meals recommended by dietitians. We also examined associations between the color characteristics of patients' meals, their clinical data, and dietary nutrients.ResultsPatients' meals exhibited significantly lower variances in chromaticity (a∗ and b∗) and lower average chroma compared to nutritionally balanced meals. Specifically, the overall mean of variance of a∗ for patients' meals was 151.1, compared to 340.5 for nutritionally balanced meals. The overall mean of average chroma for patients' meals was 24.54, whereas that for nutritionally balanced meals was 34.47. Additionally, patients' dietary patterns were found to be potentially linked not only to nutritional deficiencies but also to the prognosis and progression of hepatic fibrosis and MASLD severity.ConclusionsThis study reveals reduced color vibrancy and diversity in the diets of MASLD patients, suggesting potential dietary modifications to improve nutritional habits and clinical management for MASLD patients.
Empathy as a Psychometric Property in Dental Undergraduate Students
Authors: Anishchuk Sviatlana , Seery Aidan 
Published: December 2024

ABSTRACTObjectivesEmpathy has been an essential competency in the clinical training of dental students and plays an important role in building relationship with patients. It has been found that gender and age may influence these empathetic responses; however, the findings vary across the literature. This study aims to investigate if age, gender and type of undergraduate dental training have a dependent relationship with the level of empathy.MethodsThe participants' empathy levels were measured using the Jefferson Scale of Empathy for Health Professional Students and reported as a total score. The data were analysed using an independent t‐test to compare the means of age and gender with level of empathy. An ANOVA test was used to evaluate the mean difference between dental science, dental hygiene and dental nursing students and their level of empathy.ResultsMost of the 57 participants were females (82%). Only 10 males participated and were all members of the dental science. The male students had a higher mean empathy level (110.6) than their female peers (109) (p = 0.733); participants aged 19–23 years had a lower mean (108) empathy level than their peers aged 24 and older (114) (p = 0.113); discipline empathy levels in dental science and dental hygiene were similar (111), with a lower mean level in dental nursing (106) (p = 0.233).ConclusionThe study did not demonstrate a statistically significant difference between age, gender or discipline of undergraduate training with level of empathy. However, the results showed that age and gender have some influential relationship and should be investigated further to guide development of the educational curriculum in dental undergraduate training.
Full‐length transcriptome‐referenced analysis reveals developmental and olfactory regulatory genes in Dermestes frischii
Authors: Hu Gengwang , Li Liangliang , Li Yifei , Shao Shipeng , Zhang Ruonan , Gao Yundi , Guo Yi , Wang Yinghui , Gu Zhiya , Wang Yu 
Published: December 2024

AbstractDermestes frischii Kugelann, 1792 is a storage pest worldwide, and is important for estimating the postmortem interval in forensic entomology. However, because of the lack of transcriptome and genome resources, population genetics and biological control studies on D. frischii have been hindered. Here, single‐molecule real‐time sequencing and next‐generation sequencing were combined to generate the full‐length transcriptome of the five developmental stages of D. frischii, namely egg, young larva, mature larva, pupa and adult. A total of 41,665 full‐length non‐chimeric sequences and 59,385 non‐redundant transcripts were generated, of which 42,756 were annotated in public databases. Using the weighted gene co‐expression network analysis, gene co‐expression modules related to the five developmental stages were constructed and screened, and the genes in these modules were subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. The expression patterns of the differentially expressed genes (DEGs) related to olfaction and insect hormone biosynthesis were also explored. Transcription of most odorant binding proteins was up‐regulated in the adult stage, suggesting they are important for foraging in adults. Many genes encoding for the ecdysone‐inducible protein were up‐regulated in the pupal stage, may be mainly responsible for the tissue remodelling of metamorphosis. The results of the quantitative real‐time polymerase chain reaction (qRT‐PCR) were consistent with the RNA‐seq results. This is the first full‐length transcriptome sequencing of dermestids, and the data obtained here are vital for understanding the stage‐specific development and olfactory system of D. frischii, providing valuable resources for storage pest and forensic research.
Pharmacological characteristics of once‐weekly insulin icodec in Japanese individuals with type 1 diabetes
Authors: Eto Takashi , Haranaka Miwa , Kristensen Niels Rode , Navarria Andrea , Nishida Tomoyuki , Ribel‐Madsen Rasmus , Søgaard Stinne Byrholdt , Halberg Inge Birk 
Published: December 2024

ABSTRACTIntroductionInsulin icodec is a basal insulin designed for once‐weekly administration. This study assessed the pharmacological properties of icodec in Japanese individuals with type 1 diabetes (T1D).Materials and MethodsIn a randomized, open‐label, crossover study, 24 Japanese individuals with T1D (20–64 years; glycated hemoglobin ≤9.0%) received once‐weekly icodec for 8 weeks and once‐daily insulin glargine U100 for 14 days at individual constant equimolar doses per week together with bolus insulin aspart. Individual doses were determined during run‐in with glargine U100 titrated to prebreakfast self‐measured plasma glucose (SMPG) of 4.4–7.2 mmol/L. Blood samples for icodec pharmacokinetics were taken from the first icodec dose until 35 days after last dose. The steady‐state glucose‐lowering effect was measured in glucose clamps (target 6.7 mmol/L) during 24–48 h and 150–168 h after last icodec dose and 0–24 h after last glargine U100 dose. One‐week glucose‐lowering effect of icodec was simulated using a pharmacokinetic/pharmacodynamic model. Hypoglycemia was identified from SMPG during the treatment periods.ResultsIcodec pharmacokinetic steady state was achieved on average after 2–3 weeks of treatment. Model‐derived daily glucose‐lowering effect during the weekly dosing interval averaged 14.6%, 18.0%, 16.6%, 14.9%, 13.3%, 11.9%, and 10.7%, respectively. Rates of level 2 hypoglycemia (PG <3.0 mmol/L) were 37.3 vs 30.6 episodes per patient‐year of exposure for icodec vs glargine U100.DiscussionIcodec pharmacological properties in Japanese individuals with T1D in this study support the potential of icodec to provide basal insulin coverage with once‐weekly dosing in Japanese individuals with diabetes.
The Effect of Computer‐Aided Device on Adenoma Detection Rate in Different Implement Scenarios: A Real‐World Study
Authors: Zhang Chenxia , Tao Xiao , Pan Jie , Huang Li , Dong Zehua , Lin Jiejun , Su Huang , Zhu Yijie , Du Hongliu , Xiao Bing , Chen Mingkai , Wu Lianlian , Yu Honggang 
Published: December 2024

ABSTRACTBackgroundSeveral recent studies have found that the efficacy of computer‐aided polyp detection (CADe) on the adenoma detection rate (ADR) diminished in real‐world settings. The role of unmeasured factors in AI–human interaction, such as monitor approaches, remains unknown. This study aimed to validate the effectiveness of CADe in the real world and assess the impact of monitor approaches.MethodsA retrospective propensity score–matched cohort study was conducted using routine data from a tertiary endoscopy center in China before and after the implementation of CADe. Four propensity score–matched cohorts were established: Cohort 1: pre‐CADe matched with dual‐monitor CADe‐assisted group; Cohort 2: dual‐monitor CADe‐assisted with single‐monitor CADe‐assisted group; Cohort 3: pre‐CADe with single‐monitor CADe‐assisted group; and Cohort 4: pre‐CADe with CADe period. ADR was set as the primary outcome.ResultsThere were 5390, 6083, and 6131 eligible patients in the pre‐CADe group, dual‐monitor group, and single‐monitor group, respectively. In the matched analysis, results indicated that regardless of the monitor setup, CADe‐assisted groups showed a trend of increased ADR compared with the pre‐CADe period (CADe period: OR 1.141, 95% CI 1.047–1.243; p = 0.003; dual‐monitor: OR 1.178, 95% CI 1.069–1.299, p = 0.001; single‐monitor: OR 1.094, 95% CI 0.998–1.200, p = 0.056). Moreover, no significant difference between different monitor approaches was observed, although dual‐monitor setup showed an increasing tendency on ADR compared with single‐monitor setup (OR 1.069, 95% CI 0.985–1.161, p = 0.109).ConclusionCADe shows great potential to improve ADR during colonoscopy in the real world. Meanwhile, changes in monitor setup do not significantly impact the assistance capability of CADe. Further research dedicated to evaluating the unmeasured elements in the AI–clinician hybrid for better implementation of CADe would be beneficial.
The Baby Club: Paternity and Performance in a High‐Pressure Setting
Authors: Butler David , Butler Robert 
Published: December 2024

ABSTRACTWe offer new insights into fatherhood by asking if the onset of paternity changes workplace productivity. We do this in the well‐monitored and high‐pressure setting of professional football using a novel dataset that matches 115 birth disclosures to the performance of 96 players. Our empirical approach involves specifying a performance equation for a suite of match‐level performance statistics and estimating OLS and Poisson fixed‐effect panel regressions. We find a negative correlation between fatherhood and collaborative performance as measured by expected assists—a player's ability to create goalscoring opportunities. We also report negative effects for the perinatal period for expected assists and passing measures. There is no evidence of performance changes resulting from expectancy news. As negative performance effects are observed in a context of ‘superstar wages’, this raises concerns for high‐pressure labour markets where workers are remunerated less but have low uptake of leave entitlements or where paternity leave is culturally taboo.