bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone turnover biomarkers in COPD patients randomized to either a regular or shortened course of corticosteroids: a substudy of the randomized controlled CORTICO-COP trial
Authors: Sivapalan Pradeesh , Jørgensen Niklas R. , Mathioudakis Alexander G. , Eklöf Josefin , Lapperre Therese , Ulrik Charlotte Suppli , Andreassen Helle F. , Armbruster Karin , Sivapalan Praleene , Janner Julie , Godtfredsen Nina , Weinreich Ulla M. , Nielsen Thyge L. , Seersholm Niels , Wilcke Torgny , Schuetz Philipp , Klausen Tobias W. , Marså Kristoffer , Vestbo Jørgen , Jensen Jens-Ulrik 
Published: October 2020

Abstract
Background
Long-term treatment with corticosteroids causes loss of bone density, but the effects of using short-term high-dose systemic-corticosteroid therapy to treat acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are unclear. Our aim was to determine whether high-dose corticosteroid therapy affected bone turnover markers (BTMs) to a greater extent compared to low-dose corticosteroid therapy.

Methods
The CORTICO-COP trial (NCT02857842) showed that an eosinophil-guided corticosteroid intervention led to approximately 60% lower accumulated corticosteroid dose for hospitalized patients with AECOPD (low-dose group) compared with 5-day standard corticosteroid treatment (high-dose group). We compared the levels of BTMs C-terminal telopeptide of type 1 collagen (CTX) and procollagen type 1 N-terminal propeptide (P1NP) in 318 participants during AECOPD and at 1- and 3-month follow-up visits.

Results
CTX decreased and P1NP increased significantly over time in both treatment groups. There were no significant differences between the groups at 1- or 3-months follow-up for P1NP. A significant drop in CTX was seen at 3 months (down Δ24% from the baseline, p = 0.017) for the high dose group.

Conclusion
Short-term, high-dose systemic corticosteroid treatment caused a rapid suppression of biomarkers of bone resorption. Corticosteroids did not suppress biomarkers of bone formation, regardless of patients receiving low or high doses of corticosteroids. This therapy was, therefore, harmless in terms of bone safety, in our prospective series of COPD patients.

Trial registration
ClinicalTrials.gov Identifier: NCT02857842. Submitted August 2nd, 2016.
Clusterization in acute myeloid leukemia based on prognostic alternative splicing signature to reveal the clinical characteristics in the bone marrow microenvironment
Authors: Zhang Nan , Zhang Ping , Chen Ying , Lou Shifeng , Zeng Hanqing , Deng Jianchuan 
Published: October 2020

Abstract
Background
Alternative splicing (AS), a crucial post-transcriptional regulatory mechanism in expanding the coding capacities of genomes and increasing the diversity of proteins, still faces various challenges in the splicing regulation mechanism of acute myeloid leukemia (AML) and microenvironmental changes.

Results
A total of 27,833 AS events were detected in 8337 genes in 178 AML patients, with exon skip being the predominant type. Approximately 11% of the AS events were significantly related to prognosis, and the prediction models based on various events demonstrated high classification efficiencies. Splicing factors correlation networks further altered the diversity of AS events through epigenetic regulation and clarified the potential mechanism of the splicing pathway. Unsupervised cluster analysis revealed significant correlations between AS and immune features, molecular mutations, immune checkpoints and clinical outcome. The results suggested that AS clusters could be used to identify patient subgroups with different survival outcomes in AML, among which C1 was both associated with good outcome in overall survival. Interestingly, C1 was associated with lower immune scores compared with C2 and C3, and favorable-risk cytogenetics was rarely distributed in C2, but much more common in C1.

Conclusions
This study revealed a comprehensive landscape of AS events, and provides new insight into molecular targeted therapy and immunotherapy strategy for AML.
Modeling fire ignition probability and frequency using Hurdle models: a cross-regional study in Southern Europe
Authors: D’Este Marina , Ganga Antonio , Elia Mario , Lovreglio Raffaella , Giannico Vincenzo , Spano Giuseppina , Colangelo Giuseppe , Lafortezza Raffaele , Sanesi Giovanni 
Published: October 2020

Abstract
Background
Wildfires play a key role in shaping Mediterranean landscapes and ecosystems and in impacting species dynamics. Numerous studies have investigated the wildfire occurrences and the influence of their drivers in many countries of the Mediterranean Basin. However, in this regard, no studies have attempted to compare different Mediterranean regions, which may appear similar under many aspects. In response to this gap, climatic, topographic, anthropic, and landscape drivers were analyzed and compared to assess the patterns of fire ignition points in terms of fire occurrence and frequency in Catalonia (Spain), Sardinia, and Apulia (Italy). Therefore, the objectives of the study were to (1) assess fire ignition occurrence in terms of probability and frequency, (2) compare the main drivers affecting fire occurrence, and (3) produce fire probability and frequency maps for each region.

Results
In pursuit of the above, the probability of fire ignition occurrence and frequency was mapped using Negative Binomial Hurdle models, while the models’ performances were evaluated using several metrics (AUC, prediction accuracy, RMSE, and the Pearson correlation coefficient). The results showed an inverse correlation between distance from infrastructures (i.e., urban roads and areas) and the occurrence of fires in all three study regions. This relationship became more significant when the frequency of fire ignition points was assessed. Moreover, a positive correlation was found between fire occurrence and landscape drivers according to region. The land cover classes more significantly affected were forest, agriculture, and grassland for Catalonia, Sardinia, and Apulia, respectively.

Conclusions
Compared to the climatic, topographic, and landscape drivers, anthropic activity significantly influences fire ignition and frequency in all three regions. When the distance from urban roads and areas decreases, the probability of fire ignition occurrence and frequency increases. Consequently, it is essential to implement long- to medium-term intervention plans to reduce the proximity between potential ignition points and fuels. In this perspective, the present study provides an applicable decision-making tool to improve wildfire prevention strategies at the European level in an area like the Mediterranean Basin where a profuse number of wildfires take place.
Exploring the validity evidence of a high-stake, second language reading test: an eye-tracking study
Authors: Lim Hyojung 
Published: October 2020

AbstractThe current study aims to explore the cognitive validity of the iBT TOEFL reading test by investigating test takers’ eye movements on individual items. It is assumed that successful test takers would adopt the intended reading processes, the same types and levels of cognitive processes that they would use for real-world reading tasks. Forty-seven Chinese ESL students participated in the study, in which they took the TOEFL reading practice testlet on a computer, completed comprehension subskill tasks, and had stimulated recall interviews. Results showed that test takers tend to rely heavily on careful reading skills, while expeditious reading skills were rarely activated. The scope of reading was often restricted to the local level; learners hardly read more than a paragraph to answer questions. In some factual question items, successful readers were more efficient in reading and locating key information, whereas such group differences were not found in other items. Lastly, the gaze plots suggest that learners’ eye movements manifest various interactions between comprehension subskills, primarily subject to bottom-up linguistic processing. The limitations and implications of learners’ eye-tracking data for test validation will be further discussed.
The Impact of Korean Ambassadors’ Encounters with Qing Entertainments, Focusing on Lantern Festivals, Fireworks, Plays, and Theater Facilities
Authors: Kim Youme 
Published: October 2020

Abstract
This study examines how Chosŏn Korean ambassadors’ encounters with Qing entertainment impacted their views of the Qing dynasty in China based on their travel accounts written during the eighteenth and early nineteenth centuries. During diplomatic trips as ambassadors, select Chosŏn literati were able to experience new and exotic forms of foreign culture. This article focuses on Qing entertainments, including fireworks, lantern festivals, and plays, and related aspects such as theater facilities, that captured the attention of the traveling ambassadors. Through direct experience with Qing entertainments, traveling Chosŏn dignitaries gained first hand experience of Qing commercial and technological development. Some of these witnesses came to the realization that the Qing had become a successful ruling dynasty, which dismantled previously held assumptions by most Chosŏn literati that the Manchus were barbaric and uncultivated.
Making Sense of Fiction: Social and Political Functions of Serialized Fiction in the Daily News (Maeil sinbo) in 1910s Korea
Authors: Rhee Jooyeon 
Published: October 2020

Abstract
Modern Korean newspapers played a decisive role in transforming the Korean fiction genre in the early twentieth century―a transformation that was carried out in two distinctively different cultural and political environments. In the 1900s, reform-minded Korean intellectuals translated and authored fictional works in newspapers primarily as a way to instigate Koreans to participate in the nation-building process during the Patriotic Enlightenment movement (Aeguk kyemong undong) period. When Japan annexed Korea in 1910, the Daily News (Maeil sinbo) continually used fiction as a vehicle to deliver the colonial government’s assimilation policy, that is, to raise Korea’s socioeconomic and cultural status, with the aim of civilizing the society. The rhetoric of civilization is a common feature in fictional works produced during the period. However, what characterized the works serialized in Maeil sinbo was their increasing focus on individual desire and domestic affairs, which manifested itself in the form of courtship and familial conflicts. The confrontation between private desire and family relationships in these fictional works represented the prospect of higher education and economic equity while invoking emotional responses to the contradictory social reality of colonial assimilation in the portrayal of domestic issues in fiction. Looking at Maeil sinbo and its serialization of fiction not as a fixed totality of the Japanese imperial force but as a discursive space where contradicting views on civilization were formed, this paper scrutinizes emotional renderings of individuality and domesticity reflected in Maeil sinbo’s serialized fiction in the early 1910s.
Wandering Ghosts of the Cold War: Military Sex Workers in the Film Tour of Duty (Kŏmi ŭi ttang)
Authors: Kim Jeehey 
Published: October 2020

Abstract
This paper explores the memories of military prostitutes in US camptowns in South Korea through the film titled Tour of Duty (Kŏmi ŭi ttang, 2012). The film experiments with a genre of documentary, showcasing stories of three ex-prostitutes who struggle with their past experiences with US GIs. One of them carries on numerous dialogues with evil spirits, which give her physical and psychological pains that haunt her endlessly. Another woman keeps wandering in search of traces of her mother and friend, both of whom were prostitutes for US soldiers. She traces her memory of them around the ruins of what was called the monkey house, where US military prostitutes with venereal diseases were relocated. The film shows three women haunted by ghosts of the Cold War while remaining invisible and often forced to be silent within Korean society. The paper deals with gendered memory of the Cold War through the stories of wandering ghosts in the dilapidated streets of US camptown sites in South Korea. Pak Kyŏngt’ae and Kim Tongnyŏng, the directors of the film, challenge the boundaries of documentary film, experimenting with various filmic strategies such as interviews, monologues, fantasies, and personal memories.
Identification of selected primary bloodstream infection pathogens in patients attending Kisii level five and Homa Bay county hospitals
Authors: Kirera Ronald , Kipkirui Erick , Koech Margaret , Ombogo Abigael , Ndonye Janet , Kirui Mary , Philip Cliff Odhiambo , Kipkemoi Nancy , Odundo Elizabeth , Flynn Alexander F. , Hulseberg Christine , Walson Judd , Nganga Joseph , Kariuki Daniel 
Published: October 2020

Background: Bloodstream infection (BSI) contributes to a substantial proportion of mortality in sub-Saharan Africa and is marked by the presence of bacterial and/or fungal microorganisms in the blood. Because BSI can be life threatening, it requires a timely, reliable and accurate diagnosis. This study retrospectively analyzed data of identified BSI pathogens and compared the performance of the different diagnostic technologies used in terms of accuracy, sensitivity, turnaround time (TAT) and cost. Methods: Currently, culture followed by analytical profile index biochemical strips (API), (BioMerieux) are used as the conventional standard diagnostics in Kenyan public hospitals and labs. We compared the results of this standard to that of the BioFire FilmArray (FA) (BioFire Diagnostics) and MicroScan WalkAway-40 plus System (MS) (Beckman Coulter) used in diagnosis of BSI. The FA technology was able to identify 150/152 bacterial and yeast isolates with an overall accuracy of 99.04% (95% CI: 96.59-99.88%), sensitivity of 98.68% (95% CI: 95.33-99.84%), mean TAT of 8 hours 40 minutes per eight samples and running cost per sample of USD 140.11. The MS identified 150/152 isolates with an overall accuracy of 98.56% (95% CI: 95.86-99.70%), sensitivity of 98.68% (95% CI: 95.30-99.84%), mean TAT per sample was 42 hours and running cost per sample of USD 28.05. API detected 150/152 isolates, with an overall accuracy of 99.04% (95% CI: 96.59-99.88%), sensitivity of 98.68% (95% CI: 95.33-99.84%) and the mean TAT per sample was 53 and 103 hours for bacterial and yeast samples, respectively, with a running cost per sample of USD 28.05.Conclusions: The findings in this paper suggest that the FA and MS platforms should be able to perform adequately in Kenya referral hospitals and medical clinics as a rapid diagnostic tool.
Study on mechanism of down-regulating ikca1 molecule affecting the increment of oral squamous cell carcinoma
Authors: Liu Jianmin , Guo Ying 
Published: October 2020

This research aimed to explore the mechanism of mediating the down-regulation of the calcium-activated potassium channel (IKCa1) gene expression in human oral squamous cell carcinoma Tca-8113 cells, thereby affecting cell proliferation and apoptosis. The expression level of IKCa1 in Tca-8113 cell line (oral squamous cell carcinoma) and HOEC cell line (human normal oral epithelial cell) was detected by RT-PCR. Then, after IKCa1 was knocked down in Tca-8113 cell line and HOEC cell line by RNA interference, and then cell proliferation levels were detected by cell counting kit 8 (CCK-8) method. Cell cycle distribution was detected by flow cytometry. Apoptosis was detected by membrane linked protein V-FITC/propidium iodide (PI) double-staining apoptosis detection kit. The protein expression level of IKCa1 was detected by Western Blot method. According to RT-PRC results, IKCa1 was significantly more expressed in Tca-8113 cell line than in HOEC cell line (P< 0.01). In addition, the mRNA expression levels in the normal oral epithelium and oral squamous cell carcinoma showed the same trend. After knocking down IKCa1 in Tca-8113 cell line, the IKCa1siRNA group significantly inhibited cell proliferation compared with the siNC control group. The results of flow cytometry showed that the proportion of apoptotic Tca-8113 cells transfected with IKCa1siRNA was significantly increased. The ratio of early apoptosis and late apoptosis of Tca-8113 cells increased (P< 0.05). To investigate the effect of IKCa1 on apoptosis, we tested the expression levels of apoptosis-related proteins. The results showed that the mRNA level of IKCa1siRNA group was significantly decreased by 44.41% compared with the control group (p< 0.01). Meanwhile, the mRNA level of Bax was significantly increased by 36.0% (p< 0.05). Our results showed that knocking down IKCa1 in Tca-8113 cells could induce cell cycle arrest and apoptosis to produce an anti-proliferation effect, thus inhibiting the expression of IKCa1 has an anti-cancer effect in oral squamous cell carcinoma.
Two new spotted Chiloschista species (Orchidaceae: Aeridinae) from Bhutan
Authors: Gyeltshen Nima , Gyeltshen Choki , Tobgay Kezang , Dalström Stig , Gurung Dhan Bdr. , Gyeltshen Ngawang , Ghalley Bhakta Bdr. 
Published: October 2020

Two new spotted species of Chiloschista from Bhutan are described, illustrated, and compared with similar species. The second of the new species has been misidentified in previous publications as C. lunifera and C. parishii, and a comparison between the three is provided. It is also compared with C. glandulosa, which is a distinctly smaller-flowered species from the coastal area of southwestern India, and with C. javanica from Indonesia. The latter species and C. parishii are easily distinguished from both new species by having hairs on the backside and along the margins of the sepals and petals, as opposed to having virtually glabrous to indistinctly micro-pubescent sepals and petals for the new species. Although many spotted Chiloschista species are superficially similar, the differences can be better observed when studying the internal morphology of particularly the glandular callosity in the saccate lip. The morphological differences are often minute and difficult to describe in words, but are more easily recognized when compared with illustrations and photographs.
Key Words: Chiloschista glandulosa, C. javanica, C. lunifera, C. parishii, new Chiloschista
Modèle épidémiologie stochastique dans un population structurée en âge
Authors: Yéo Yardjouma 
Published: October 2020

Dans ce papier, on s'interesse à l'étude des modèles épidémiologique dans un population structurée en âge. Il s'agit d'abord de construire un modèle épidémiologique structurée en age. Ce modèle étant déterministe, il n'est donc pas valable dans une population de petite taille. Cela va nous permet de construire sa version stochastique. Notre travail est ensuite de votre si cette version stochastique converge vers le modèle déterministe. Pour terminer, par la méhode des simulations on prouve ce même resutats.
CONVOLUTIONAL NEURAL NETWORKS AS AN AID TO BIOSTRATIGRAPHY AND MICROPALEONTOLOGY: A TEST ON LATE PALEOZOIC MICROFOSSILS
Authors: PIRES DE LIMA RAFAEL , WELCH KATIE F. , BARRICK JAMES E. , MARFURT KURT J. , BURKHALTER ROGER , CASSEL MURPHY , SOREGHAN GERILYN S. 
Published: October 2020

ABSTRACTAccurate taxonomic classification of microfossils in thin-sections is an important biostratigraphic procedure. As paleontological expertise is typically restricted to specific taxonomic groups and experts are not present in all institutions, geoscience researchers often suffer from lack of quick access to critical taxonomic knowledge for biostratigraphic analyses. Moreover, diminishing emphasis on education and training in systematics poses a major challenge for the future of biostratigraphy, and on associated endeavors reliant on systematics. Here we present a machine learning approach to classify and organize fusulinids—microscopic index fossils for the late Paleozoic. The technique we employ has the potential to use such important taxonomic knowledge in models that can be applied to recognize and categorize fossil specimens. Our results demonstrate that, given adequate images and training, convolutional neural network models can correctly identify fusulinids with high levels of accuracy. Continued efforts in digitization of biological and paleontological collections at numerous museums and adoption of machine learning by paleontologists can enable the development of highly accurate and easy-to-use classification tools and, thus, facilitate biostratigraphic analyses by non-experts as well as allow for cross-validation of disparate collections around the world. Automation of classification work would also enable expert paleontologists and others to focus efforts on exploration of more complex interpretations and concepts.
The effectiveness and safety of D2 plus para-aortic lymphadenectomy for resectable gastric cancer: a systematic review and meta-analysis
Authors: Zou Shi-Hui , Zhong Xi , Zhang Jia-Le , Huang Bao-Jun , Xu Hui-Mian , Liu Jin-Xin 
Published: October 2020

Abstract
Background: Gastric cancer (GC) is among the malignant tumors of highest morbidity and mortality in the world, and has a profile of high lymph node metastasis rate. Lymph node clearance is a critical part of gastric cancer surgery, however, the extent of lymph node clearance, for example, whether to perform abdominal aortic lymph node dissection, remains considerably controversial. In this study, we performed a systematic review and meta-analysis to assess the effects of D2 plus para-aortic lymphadenectomy (PALD) on survival and postoperative complications in patients with GC.Methods: An electronic search was conducted through PubMed, Embase and cochrane library. The Q test and I2 were used to assess heterogeneity. The publication bias was evaluated via funnel plots. All statistical analyses were performed using STATA 14.0 (STATA, College Station, TX).Results: 908 studies were retrieved via literature search and eight studies were finally included. There was no significant difference between D2 and D2+PALD in the 5-year survival rate after surgery (HR: 1.00, 95% CI: 0.97-1.03, P = 0.897; I2 = 64.9%). Besides, the 30-day mortality (RR: 1.17, 95% CI: 0.66-2.10, P = 0.590; I2 = 0.0%) and the overall risk of postoperative complications (RR: 1.15, 95% CI: 0.83-1.59, P = 0.411; I2 = 35.5%) were comparable between D2 and D2+PALD.Conclusion: Based on current literature body, compared with D2, D2+PALD does not prevail in terms of long-term survival or perioperative outcomes.