bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological findings in frozen non-neoplastic kidney tissues of patients with kidney cancer from large-scale multicentric studies on renal cancer
Authors: Abedi-Ardekani Behnoush , Nasrollahzadeh Dariush , Egevad Lars , Banks Rosamonde E. , Vasudev Naveen , Holcatova Ivana , Povysil Ctibor , Foretova Lenka , Janout Vladimir , Mates Dana , Jinga Viorel , Petrescu Amelia , Milosavljevic Sasa , Ognjanovic Miodrag , Ognjanovic Simona , Viksna Juris , Warren Anne Y. , Lathrop Mark , Riazalhosseini Yasser , Carreira Christine , Chanudet Estelle , McKay James , Brennan Paul , Scélo Ghislaine 
Published: January 2021

AbstractThere are unexplained geographical variations in the incidence of kidney cancer with the high rates reported in Baltic countries, as well as eastern and central Europe. Having access to a large and well-annotated collection of “tumor/non-tumor” pairs of kidney cancer patients from the Czech Republic, Romania, Serbia, UK, and Russia, we aimed to analyze the morphology of non-neoplastic renal tissue in nephrectomy specimens. By applying digital pathology, we performed a microscopic examination of 1012 frozen non-neoplastic kidney tissues from patients with renal cell carcinoma. Four components of renal parenchyma were evaluated and scored for the intensity of interstitial inflammation and fibrosis, tubular atrophy, glomerulosclerosis, and arterial wall thickening, globally called chronic renal parenchymal changes. Moderate or severe changes were observed in 54 (5.3%) of patients with predominance of occurrence in Romania (OR = 2.67, CI 1.07–6.67) and Serbia (OR = 4.37, CI 1.20–15.96) in reference to those from Russia. Further adjustment for comorbidities, tumor characteristics, and stage did not change risk estimates. In multinomial regression model, relative probability of non-glomerular changes was 5.22 times higher for Romania and Serbia compared to Russia. Our findings show that the frequency of chronic renal parenchymal changes, with the predominance of chronic interstitial nephritis pattern, in kidney cancer patients varies by country, significantly more frequent in countries located in central and southeastern Europe where the incidence of kidney cancer has been reported to be moderate to high. The observed association between these pathological features and living in certain geographic areas requires a larger population-based study to confirm this association on a large scale.
Impact of the weekend effect on outcome after microsurgical clipping of ruptured intracranial aneurysms
Authors: Goertz Lukas , Kabbasch Christoph , Pflaeging Muriel , Pennig Lenhard , Laukamp Kai Roman , Timmer Marco , Styczen Hanna , Brinker Gerrit , Goldbrunner Roland , Krischek Boris 
Published: January 2021

Abstract
Background
The “weekend effect” describes the assumption that weekend and/or on-call duty admission of emergency patients is associated with increased morbidity and mortality rates. For aneurysmal subarachnoid hemorrhage, we investigated, whether presentation out of regular working hours and microsurgical clipping at nighttime correlates with worse patient outcome.

Methods
This is a retrospective review of consecutive patients that underwent microsurgical clipping of an acutely ruptured aneurysm at our institution between 2010 and 2019. Patients admitted during (1) regular working hours (Monday–Friday, 08:00–17:59) and (2) on-call duty and microsurgical clipping performed during (a) daytime (Monday–Sunday, 08:00–17:59) and (b) nighttime were compared regarding the following outcome parameters: operation time, treatment-related complications, vasospasm, functional outcome, and angiographic results.

Results
Among 157 enrolled patients, 104 patients (66.2%) were admitted during on-call duty and 48 operations (30.6%) were performed at nighttime. Admission out of regular hours did not affect cerebral infarction (p = 0.545), mortality (p = 0.343), functional outcome (p = 0.178), and aneurysm occlusion (p = 0.689). Microsurgical clipping at nighttime carried higher odds of unfavorable outcome at discharge (OR: 2.3, 95%CI: 1.0–5.1, p = 0.039); however, there were no significant differences regarding the remaining outcome parameters. After multivariable adjustment, clipping at nighttime did not remain as independent prognosticator of short-term outcome (OR: 2.1, 95%CI: 0.7–6.2, p = 0.169).

Conclusions
Admission out of regular working hours and clipping at nighttime were not independently associated with poor outcome. The adherence to standardized treatment protocols might mitigate the “weekend effect.”
Precipitation cycles in Turkey
Authors: Yılmaz Erkan , Akdi Yılmaz , Uğurca Esra , Çiçek İhsan , Atakan Cemal 
Published: January 2021

AbstractTurkey is located in the temperate zone; thus, it is influenced by regionally different air masses during summers and winters, resulting in different precipitation regimes. Often, systems with varying masses of air repeatedly affect Turkey; however, at times, these periods are disrupted and difficult to predict. This study analyzes whether a certain periodicity exists in the seasonal and annual total precipitation of 74 meteorological stations in Turkey using periodograms. The analyses conducted herein showed more than one period in the series; therefore, this study was extended, and the first six periods were examined. As a result, we found 2-, 3-, 4-, and 5-year precipitation cycles (PCs) in the short term; 6-, 7-, and 8-year PCs in the medium term; and 11-, 12-, 14-, 17-, and 21-year PCs in the long term in Turkey’s PC. While seasonal distributions exhibited similarities, there were significant differences in the seasonal frequencies owing to seasonal variations in the systems affecting Turkey. The cycles vary by region, and some of these cycles can be found in each region. Three cycles have been identified in Turkey according to frequency and length, namely: (1) short-term cycle across Turkey; (2) Eastern and Central Anatolia, the Black Sea, and Aegean regions; and (3) borders of Central Anatolian and the eastern Mediterranean region. A cluster identifies unrelated locations as the affected local factors. Cycles are connected to the NAO, whereas solar activity is observed throughout Turkey. The analysis showed that certain cycles were repeated and were not dominant in each period, with the best example of this cycle as the 7–14–21 consecutive cycles.
Quantifying the parameter dependent basin of the unsafe regime of asymmetric Lévy-noise-induced critical transitions
Authors: Ma Jinzhong , Xu Yong , Li Yongge , Tian Ruilan , Ma Shaojuan , Kurths J. 
Published: January 2021

AbstractIn real systems, the unpredictable jump changes of the random environment can induce the critical transitions (CTs) between two non-adjacent states, which are more catastrophic. Taking an asymmetric Lévy-noise-induced tri-stable model with desirable, sub-desirable, and undesirable states as a prototype class of real systems, a prediction of the noise-induced CTs from the desirable state directly to the undesirable one is carried out. We first calculate the region that the current state of the given model is absorbed into the undesirable state based on the escape probability, which is named as the absorbed region. Then, a new concept of the parameter dependent basin of the unsafe regime (PDBUR) under the asymmetric Lévy noise is introduced. It is an efficient tool for approximately quantifying the ranges of the parameters, where the noise-induced CTs from the desirable state directly to the undesirable one may occur. More importantly, it may provide theoretical guidance for us to adopt some measures to avert a noise-induced catastrophic CT.
Can HRV Biofeedback Improve Short-Term Effort Recovery? Implications for Intermittent Load Sports
Authors: Perez-Gaido Mauro , Lalanza Jaume F. , Parrado Eva , Capdevila Lluis 
Published: January 2021

AbstractAs intensity and physical demands continue to rise in sport competition, faster and better recovery becomes essential. The aim of this study was to assess the effects of HRV biofeedback (HRVB) while recovering from a submaximal aerobic exercise. Ten physically-active graduate students participated in the study, which was conducted in four sessions: exercise with free-breathing recovery, first resonance frequency (RF) detection, second RF detection, and exercise applying HRVB during recovery. Measurements included time spent running and recovering, HRV parameters, and recovery/exertion perceptions. The results indicate that using HRVB during recovery improves cardiac variability (RRmean, SDNN, RMSSD and LF; p < 0.01). HRVB also lowers recovery time (p < 0.05) and seems to be improving the perception of recovery (p = 0.087). Moreover, time spent exercising (p < 0.01) and perceived physical exertion (p < 0.05) were higher when applying HRVB. The improvement in the psychophysiological adaptation after intensive aerobic exercise provided by the HRVB is a valuable benefit, not only for competition-driven athletes, but also for the general population.
Estimate of turbulent energy dissipation rate using free-fall and CTD-attached fast-response thermistors in weak ocean turbulence
Authors: Yasuda Ichiro , Fujio Shinzou , Yanagimoto Daigo , Lee KeungJong , Sasaki Yusuke , Zhai Shuo , Tanaka Mamoru , Itoh Sachihiko , Tanaka Takahiro , Hasegawa Daisuke , Goto Yasutaka , Sasano Daisuke 
Published: January 2021

AbstractThe measurement of turbulence is necessary to quantify the vertical, diapycnal transport of heat, water and substances influencing climate, nutrient supply and marine ecosystems. As specialist instrumentation and ship-time are required to conduct microstructure measurements to quantify turbulence intensity, there is a need for more inexpensive and easy measurement methods. This study demonstrated that the turbulent energy dissipation rate, ε, estimated from fast-response thermistors Fastip Probe model 07 (FP07) with the depth-average of a > 10 m depth interval well agreed with those from current shear probes to a range of 10–11 W/kg (m2s−3) in the two casts of the most accurate and stable free-fall vertical microstructure profiler, VMP6000 in the Oyashio water. This range cannot be measured with velocity shear probes equipped in smaller profilers in which the lower limit of ε > O (10–10) W/kg. These results extend turbulence measurements using the FP07 to 10–11 W/kg. They may be especially useful for turbulence observations in deep oceans where ε is generally weak (< 10–10 W/kg). As FP07 are much less sensitive to instrument vibrations than current shear and may be attached to various observational platforms such as temperature-conductivity-depth (CTD) profilers and floats. The CTD-attached FP07 observations near the VMP6000 profiles demonstrated their capabilities in the ε range of 10–11–10–8 W/kg by data screening using a $${W}_{\mathrm{sd}}>0.1(W-0.3)$$

W
sd

>
0.1

(
W
-
0.3
)

criterion (1 s mean lowering rate $$W$$
W
m/s and its standard deviation $${W}_{\mathrm{sd}}$$

W
sd

) under rough conditions where the cast-mean $${W}_{\mathrm{sd}}>$$

W
sd

>

0.07 m/s and the standard deviation of $${W}_{\mathrm{sd}}$$

W
sd

in each cast $$\sigma$$
σ
>0.05 m/s.
What Explains Gender Gaps in Household Food Security? Evidence from Maize Farm Households in Southern Ethiopia
Authors: Gebre Girma Gezimu , Isoda Hiroshi , Amekawa Yuichiro , Rahut Dil Bahadur , Nomura Hisako , Watanabe Takaaki 
Published: January 2021

AbstractUsing primary data collected from 560 farm households in Dawuro zone, southern Ethiopia, this study analyzes the gender gaps in food security among male, female, and joint decision-making farm households. It examines the factors inducing gender gaps among the households of those three categories. The results show that female decision-making households have a lower probability of ensuring food-security and a higher probability of being transitionally and chronically food-insecure. Joint decision-making households showed a higher probability of falling into the chronically food-insecure category. The decomposition results show significant gender gaps between male and female decision-making households in terms of food-secure, transitory food-insecure, and chronically food-insecure categories. Overall, both the endowment and return effects account for the gaps; however, the magnitude of the effect from the return is higher than from the endowment on significant gaps in the food-secure, transitory, and chronically food-insecure categories. Hence, there is a need for policies that not only ensure equal levels of productive resources but also help households build their capacity in order to improve both transitory and chronically food insecure situations.
The tensile root strength of Spartina patens declines with exposure to multiple stressors
Authors: Hollis Lauris O. , Turner R. Eugene 
Published: January 2021

AbstractCoastal wetlands may be subjected to numerous biotic and abiotic stressors from natural and anthropogenic forces in the landscape. The influx of nutrients, inorganic compounds and xenobiotics are suspected of degrading the belowground biomass of coastal macrophytes. Spartina patens acts as an ecosystem engineer for lower salinity coastal marshes and its biomechanical properties are vital to the stability and resilience of coastal wetlands. S.patens was exposed to one natural (flooding) and two anthropogenic stressors (atrazine and nutrient addition) in a greenhouse experiment to test the hypothesis that these three stressors reduce the tensile root strength of S. patens. A one-way Welch’s analysis of variance revealed that the tensile root strength S. patens significantly declined after exposure to two flood duration regimes, three levels of atrazine exposure, and two levels of nutrient addition that consisted of nitrogen-phosphorus combinations. A one-way ANOVA of tensile root strength with an atrazine-flood duration-nutrient addition combination treatment as the main effect resulted in a 52 to 63% loss in tensile strength, while the individual atrazine, flooding, and nutrient treatments produced 40, 39, and 37% losses in tensile root strength, respectively. These results indicate that the effects of multiple natural and/or anthropogenic stressors may degrade the tensile root strength of S. patens, which could facilitate coastal erosion and subsequent collapse of the wetland ecosystem.
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia
Authors: Li Jianfeng , Dai Yuting , Wu Liang , Zhang Ming , Ouyang Wen , Huang Jinyan , Chen Saijuan 
Published: January 2021

AbstractB-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic alterations with high heterogeneity. Precise subtypes with distinct genomic and/or gene expression patterns have been recently revealed using high-throughput sequencing technology. Most of these profiles are associated with recurrent non-overlapping rearrangements or hotspot point mutations that are analogous to the established subtypes, such as DUX4 rearrangements, MEF2D rearrangements, ZNF384/ZNF362 rearrangements, NUTM1 rearrangements, BCL2/MYC and/or BCL6 rearrangements, ETV6-RUNX1-like gene expression, PAX5alt (diverse PAX5 alterations, including rearrangements, intragenic amplifications, or mutations), and hotspot mutations PAX5 (p.Pro80Arg) with biallelic PAX5 alterations, IKZF1 (p.Asn159Tyr), and ZEB2 (p.His1038Arg). These molecular subtypes could be classified by gene expression patterns with RNA-seq technology. Refined molecular classification greatly improved the treatment strategy. Multiagent therapy regimens, including target inhibitors (e.g., imatinib), immunomodulators, monoclonal antibodies, and chimeric antigen receptor T-cell (CAR-T) therapy, are transforming the clinical practice from chemotherapy drugs to personalized medicine in the field of risk-directed disease management. We provide an update on our knowledge of emerging molecular subtypes and therapeutic targets in BCP-ALL.
The design fluency test: a reliable and valid instrument for the assessment of game intelligence?
Authors: Finkenzeller Thomas , Krenn Björn , Würth Sabine , Amesberger Günter 
Published: January 2021

AbstractThe design fluency test (DFT) has been reported to predict successful sports performance of soccer players and has therefore been in the spotlight of sport psychology research. There is, however, a lack of research regarding the psychometric properties of the DFT in elite sports. Thus, the aim of this research was to provide findings of test–retest reliability, practice effects and the diagnostic power of the DFT. Multiple studies of youth and adult elite athletes, as well as nonathlete students, were conducted in applied settings. Test–retest relationship demonstrated poor to acceptable short-term and long-term correlations. Furthermore, significant changes between test and retest were obtained in some variables that differed among samples. The differential value of the DFT was corroborated by significant differences between adolescent students and adolescent elite soccer players. Regarding the prospective value, significant partial correlation coefficients were found between DFT scores and volleyball performance in adult elite players. Although our research partially confirmed previous findings on the differential and prospective power of the DFT, the findings on test–retest reliability indicate that the DFT cannot be recommended for application in sports. The psychometric properties—in particular the findings on test–retest reliability—of the DFT have to be improved before research can be carried out on the application for the selection of team sport athletes and for the prediction of future success in team sports. Further research is needed to develop a scientific instrument for the assessment of game intelligence.
Cognitive training in elite soccer players: evidence of narrow, but not broad transfer to visual and executive function
Authors: Scharfen Hans-Erik , Memmert Daniel 
Published: January 2021

AbstractVisual and executive functions have been suggested to be crucial in high-demanding team sports. Consequently, the interest in evaluating training possibilities of these functions is relatively high. However, easily applicable training tools, as well as evidence of their efficacy, especially in the present group of age (i.e. 17–21 years) and performance level, are scarce. Therefore, the present study aimed to evaluate the effectiveness and transfer of an essential cognitive training tool (i.e. NeuroTracker [NT] three dimensional [3D] multiple-object tracking [MOT]) in youth elite soccer players. Visual and executive functions were analyzed in a pre–post test design with an intervention and a control group after 10 weeks of training twice a week. Physical activity was included as a possible covariate. Results show meaningful benefits in the trained ability (i.e. MOT) besides small but negligible improvements in visual clarity and inhibition for the intervention group. Consequently, strict single-task NT 3D-MOT seems to have little transfer to other visual or executive functions. However, future studies should investigate the effects of sport-specific dual-task NT 3D-MOT to analyze possible multitasking adaptations further.
Determinants of pro-environmental behavior among voluntary sport club members
Authors: Thormann Tim F. , Wicker Pamela 
Published: January 2021

AbstractEnvironmental sustainability and climate change have become increasingly important in public debates and politics. This study examines the determinants of sport club members’ pro-environmental behavior in Germany. Theoretically, we draw on the theory of planned behavior, ecofeminism, and the luxury good hypothesis to explain the effects of individuals’ environmental consciousness, gender, and income on their pro-environmental behavior, respectively. Data collection took place in 2019 and 2020 via a nationwide online survey of active sport club members in five team/racket sports (n = 3038). Regression analyses were estimated to examine the determinants of two indicators of pro-environmental behavior, i.e., the monthly carbon footprint resulting from traveling to training sessions and pro-environmental actions. The results reveal that environmentally consciousness members behave more environmentally friendly, supporting the theory of planned behavior. Women have a significantly higher carbon footprint, but only in the model including the interaction with environmental consciousness, indicating that female gender only works in conjunction with environmental attitudes. Income is associated with a significantly higher carbon footprint for training, while it has no effect on pro-environmental actions related to club sport. The findings have implications for sport managers and policy makers.
Effective Parameter of Nano-CuO Coating on CO Gas-Sensing Performance and Heat Transfer Efficiency
Authors: Mahmood M. H. , Maleque M. A. 
Published: January 2021

AbstractThe high gas-sensing performance of semiconductors is mainly due to the high surface-to-volume ratio because it permits a large exposed surface area for gas detection. This paper presents an evaluation study for the effects of nano-CuO coating parameters on the CO gas-sensing performance. The effects on gas-sensing performance and heat transfer efficiency of CuO coating were evaluated by investigating the effects of coating parameters (concentration, temperature, and solution speed) on thickness, grain size, and porosity. The CuO nanoparticle coatings were synthesized using the oxidation method at various operating conditions. Coating characteristics were investigated using X-ray diffraction, energy dispersive X-ray Spectroscopy, field emission scanning electron microscopy, and electrical resistivity meter. The average coating thickness, grain size, and porosity were around 13 μm, 48 nm, and 30%, respectively. The thermal transfer and gas-sensing properties of CuO coating were evaluated according to the total surface area of the coating formed at various operating conditions. The gas-sensing and thermal transfer performance were obtained from the optimization of coating parameters based on the coating morphology to achieve the highest contact surface area. The coating’s surface area was increased by 350 times, which improved the heat transfer efficiency of 96.5%. The result shows that the coating thickness increased with the increase in solution concentration and decrease the temperature. The results also show that the sensitivity of the coating for CO gas was increased by 50% due to the reduction of coatings grain size.
An elementary derivation of Hattendorff’s theorem
Authors: Shiu Elias S. W. , Xiong Xiaoyi 
Published: January 2021

AbstractFor a general fully continuous life insurance model, the variance of the loss-at-issue random variable is the expectation of the square of the discounted value of the net amount at risk at the moment of death. In 1964 Jim Hickman gave an elementary and elegant derivation of this result by the method of integration by parts. One might expect that the method of summation by parts could be used to treat the fully discrete case. However, there are two difficulties. The summation-by-parts formula involves shifting an index, making it somewhat unwieldy. In the fully discrete case, the variance of the loss-at-issue random variable is more complicated; it is the expectation of the square of the discounted value of the net amount at risk at the end of the year of death times a survival probability factor. The purpose of this note is to show that one can indeed use the method of summation by parts to find the variance of the loss-at-issue random variable for a fully discrete life insurance policy.