bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid reality development - can social responsibility concepts provide guidance?
Authors: Perko Igor 
Published: October 2020

Purpose
This paper aims to define hybrid reality (HyR) as an ongoing process in which artificial intelligence (AI) technology is gradually introduced as an active stakeholder by using reasoning to execute real-life activities. Also, to examine the implications of social responsibility (SR) concepts as featured in the HyR underlying common framework to progress towards the redefinition of global society.

Design/methodology/approach
A combination of systemic tools is used to examine and assess the development of HyR. The research is based on evolutionary and learning concepts, leading to the new meta-system development. It also builds upon the viable system model and AI, invoking SR as a conceptual framework. The research is conducted by using a new approach: using system dynamics based interactions modelling, the following two models have been proposed. The state-of-the-art HyR interactions model, examined using SR concepts; and a SR concept-based HyR model, examined using a smart vehicle case.

Findings
In the HyR model, interaction asymmetry between stakeholders is identified, possibly leading to pathological behaviour and AI technology learning corruption. To resolve these asymmetry issues, an interaction model based on SR concepts is proposed and examined on the example of an autonomous vehicle transport service. The examination results display significant changes in the conceptual understanding of transport services, their utilisation and data-sharing concepts.

Research limitations/implications
As the research proposal is theoretical in nature, the projection may not display a fully holistic perspective and can/should be complemented with empirical research results.

Practical implications
For researchers, HyR provides a new paradigm and can thereby articulate potential research frameworks. HyR designers can recognise projected development paths and the resources required for the implication of SR concepts. Individuals and organisations should be aware of their not necessarily passive role in HyR and can therefore use the necessary social force to activate their status.

Originality/value
For the first time, to the best of the author’s knowledge, the term HyR is openly elaborated and systemically examined by invoking concepts of SR. The proposed model provides an overview of the current and potential states of HyR and examines the gap between them.
Decision and coordination of a low-carbon supply chain considering environmental tax policy on consumers
Authors: Wang Chuanxu , Peng Qiaoyu , Xu Lang 
Published: October 2020

Purpose
This paper aims to explore how upstream supply chain companies will control the carbon emissions and price decisions of products when the government implements environmental tax policy on consumers. It provides some suggestions to control carbon emissions for the government and manufacturers.

Design/methodology/approach
This study establishes two-echelon Stackelberg game models with and without the implementation of environmental tax policy on consumers in a centralized scenario and a decentralized scenario. Through the comparative analysis of the four models, the optimal emission abatement and pricing strategies are obtained.

Findings
This paper concludes that implementing environmental tax policy on consumers within the market’s acceptable range is more beneficial to the retailer and the environment, as well as the overall social welfare, except for the manufacturer. Moreover, consumer’s low-carbon preference always has a broader impact on carbon abatement and corporate profits than environmental tax coefficient. Finally, the side-payment self-executing contract can effectively ensure that the supply chain members make rational decisions spontaneously while achieving a win-win solution of centralized scenario.

Originality/value
This paper first considers how the government’s environmental tax policy on consumers will affect the decision-making of supply chain companies, and proposes an improved side-payment self-enforcing contract to maximize environmental and economic benefits of centralized scenario. In addition, it provides a reference for the government to adopt both the carbon cap policy and the environmental tax policy.
Hedonic valuation of apartments in Kenya
Authors: Kieti Raphael Mutisya , Ogolla Walter 
Published: October 2020

PurposeThis paper applies the hedonic pricing model (HPM) approach to identify critical determinants of apartment value and employs the technique to develop a valuation model that can accurately estimate the value of apartments.Design/methodology/approachThe research employed a case study design that was limited to transaction sales and attribute data of apartments in Nyali estate, Mombasa County in Kenya. A sample of 120 sales of apartments obtained from registered real estate firms was analyzed using quantitative methods.FindingsAccording to the study results, the hedonic valuation model developed comprises four critical determinants of apartment value, namely, number of parking lots, presence of swimming pool, age of apartment and provision of balcony. The hedonic model was tested and found to be accurate and reliable in estimating apartment value.Research limitations/implicationsThe model will improve accuracy, reliability and efficiency in valuation. The application of the model in the valuation of apartments is, however, limited to the case study area where the data are obtained. The scope of application of the model may be improved by increasing the sample size to include apartment sales data from other estates in Mombasa County.Originality/valuePrevious studies that have used the HPM technique in analysis of apartment values have focused on the “explanatory” and “contributory” power of attributes on apartment values, rather than the development and use of the model to measure value. The present study is the first to develop a HPM equation for property value estimation in the apartment real estate sector in Kenya.
The effect of induced mood on traders’ preferences in asset markets – experimental evidence
Authors: Lahav Yaron , Meer Shireen 
Published: October 2020

PurposeIn this paper, we study the effect of induced positive and negative moods on traders' willingness to trade (pay and accept) in experimental asset markets.Design/methodology/approachWe conduct experimental asset markets where subjects undergo a mood induction procedure prior to trade. After the subjects are induced with either negative or positive affect, they can trade an experimental asset with a known stream of dividends for a known number of periods.FindingsWe first show that both positive and negative affects are associated with larger positive deviations from fundamental values. We also show that when subjects are induced with positive mood, they bid higher prices but for fewer units of the stock. On the supply side, positive affect is associated with higher prices and quantities, and consequently in higher willingness to offer. Finally, we use our experimental data to test existing theories on mood effect. We find that negative affect is related to momentum trading, while positive affect is associated with information processing.Originality/valueTo our knowledge, this is the first work that studies the effect of mood on traders' behavior, rather than market outcomes.
Two-layer fabrics for moisture management
Authors: Niles Nilhan , Fernando Sandun , Rathnayake Nipuni , Hewamalavi Ayesha , Weerasinghe Samudika 
Published: October 2020

Purpose
Woven fabrics have been popularised in use owing to their superior properties and functionality. Today, weavers strive to add value to their product to be competitive and to secure profit in performance fabrics such as technical fabrics, smart fabrics and sportswear fabrics. Over the years, fabrics with special properties such as moisture management have gained higher demand. In this context, multi-layer fabrics provide a reasonable solution to the demand.

Design/methodology/approach
An attempt was made to develop two-layer fabrics with different compositions and properties. A two-layer woven fabric was produced using handloom weaving, with a hydrophobic inner layer and hydrophilic outer layer, the two layers being attached together using different stitching methods. Different fabric structures and yarn counts were used to achieve the objectives.

Findings
Experiments carried out verified the suitability of the developed fabric for effective moisture management. It was found that a fabric with a 100% cotton outer layer and 100% polyester inner layer, both layers of 2 × 2 matt weave, showed the best properties.

Practical implications
In the present COVID-19 pandemic situation, the use of masks in public has become mandatory in many countries. This research will help handloom manufacturers meet the need using simple methods.

Originality/value
This research uses handloom fabric. As such it provides an opportunity for small and medium enterprises to use available low-cost technology to develop fabric with superior properties.
Xenorhabdus nematophila bacteria shift from mutualistic to virulent Lrp‐dependent phenotypes within the receptacles of Steinernema carpocapsae insect‐infective stage nematodes
Authors: Cao Mengyi , Goodrich‐Blair Heidi 
Published: October 2020

SummaryXenorhabdus nematophila bacteria are mutualists of Steinernema carpocapsae nematodes and pathogens of insects. Xenorhabdus nematophila exhibits phenotypic variation between insect virulence (V) and the mutualistic (M) support of nematode reproduction and colonization initiation in the infective juvenile (IJ) stage nematode that carries X. nematophila between insect hosts. The V and M phenotypes occur reciprocally depending on levels of the transcription factor Lrp: high‐Lrp expressors are M+V− while low‐Lrp expressors are V+M−. We report here that variable (wild type) or fixed high‐Lrp expressors also are optimized, relative to low‐ or no‐Lrp expressors, for colonization of additional nematode stages: juvenile, adult and pre‐transmission infective juvenile (IJ). In contrast, we found that after the bacterial population had undergone outgrowth in mature IJs, the advantage for colonization shifted to low‐Lrp expressors: fixed low‐Lrp expressors (M−V+) and wild type (M+V+) exhibited higher average bacterial CFU per IJ than did high‐Lrp (M+V−) or no‐Lrp (M−V−) strains. Further, the bacterial population becomes increasingly low‐Lrp expressing, based on expression of an Lrp‐dependent fluorescent reporter, as IJs age. These data support a model that virulent X. nematophila have a selective advantage and accumulate in aging IJs in advance of exposure to insect hosts in which this phenotype is necessary.
Comparative genomics reveals the in planta‐secreted Verticillium dahliae Av2 effector protein recognized in tomato plants that carry the V2 resistance locus
Authors: Chavarro‐Carrero Edgar A. , Vermeulen Jasper P. , E. Torres David , Usami Toshiyuki , Schouten Henk J. , Bai Yuling , Seidl Michael F. , Thomma Bart P. H. J. 
Published: October 2020

SummaryPlant pathogens secrete effector molecules during host invasion to promote colonization. However, some of these effectors become recognized by host receptors to mount a defence response and establish immunity. Recently, a novel resistance was identified in wild tomato, mediated by the single dominant V2 locus, to control strains of the soil‐borne vascular wilt fungus Verticillium dahliae that belong to race 2. With comparative genomics of race 2 strains and resistance‐breaking race 3 strains, we identified the avirulence effector that activates V2 resistance, termed Av2. We identified 277 kb of race 2‐specific sequence comprising only two genes encoding predicted secreted proteins that are expressed during tomato colonization. Subsequent functional analysis based on genetic complementation into race 3 isolates and targeted deletion from the race 1 isolate JR2 and race 2 isolate TO22 confirmed that one of the two candidates encodes the avirulence effector Av2 that is recognized in V2 tomato plants. Two Av2 allelic variants were identified that encode Av2 variants that differ by a single acid. Thus far, a role in virulence could not be demonstrated for either of the two variants.
US State Polarization, Policymaking Power, and Population Health
Authors: MONTEZ JENNIFER KARAS 
Published: October 2020

Policy Points
Explanations for the troubling trend in US life expectancy since the 1980s should be grounded in the dynamic changes in policies and political landscapes. Efforts to reverse this trend and put US life expectancy on par with other high‐income countries must address those factors.
Of prime importance are the shifts in the balance of policymaking power in the United States, the polarization of state policy contexts, and the forces behind those changes.
Validity of the use of porcine bone in forensic cut mark studies
Authors: Bonney Heather , Goodman Adrian 
Published: October 2020

AbstractPorcine bone is often used as a substitute for human bone in forensic trauma studies, but little has been published on its comparative mechanical behavior. The factors affecting mechanical properties and therefore selection of bone models are complex and include the age of the animal at death, and physiological loading conditions, the latter being of particular relevance when using a quadrupedal animal as a human substitute. The regional variation in hardness of adult and infant porcine bones was investigated using Vickers’ indentation tests and compared to published data for human limb bones to relate differences to inherent genetic effects and loading influences, and to examine the validity of the porcine‐human model. Significant differences in hardness were observed both along and around the adult porcine humerus and femur, but no significant differences were found along the length of the infant bones. Significant differences were found between the forelimb and hindlimb, but only in the infant specimens. The hardness values for porcine adult cortical bone from the femur (52.23 ± 1.00 kg mm−2) were comparable to those reported in the literature for adult human cortical bone from the fibula, ilium, and calcaneus. These data will help inform subject selection in terms of both species and bone type for use in future trauma studies.
Mental health presentations to Christchurch Hospital Emergency Department during COVID‐19 lockdown
Authors: Joyce Laura R , Richardson Sandra K , McCombie Andrew , Hamilton Greg J , Ardagh Michael W 
Published: October 2020

AbstractObjectiveTo describe mental health presentations to a tertiary ED in New Zealand during a national COVID‐19 lockdown.MethodsA retrospective, comparative cohort study in Christchurch Hospital, New Zealand.ResultsThere was a 3510 (37%)‐patient decrease in all presentations to Christchurch Hospital ED during the 5‐week COVID‐19 lockdown period from 26 March 2020 to 28 April 2020, compared to a 111 (1.2%)‐patient decrease in the same time period in the previous year (P < 0.00001). There is usually a seasonal reduction in mental health attendances at this time of year compared to the weeks before. In 2019, there was a 49 (9.8%)‐patient reduction in mental health presentations, whereas in 2020 there was a 193 (34%)‐patient reduction (P < 0.001). In 2020, the proportion of mental health attendances compared to all ED attendances during the 5‐week lockdown period was similar to the 5‐week pre‐lockdown period (564/9460 vs 371/5950, P = 0.48). The proportion of mental health patients presenting due to overdose increased by 6.5% (158/564 vs 128/371, P = 0.035); those due to self‐harm increased by 3.5% (35/564 vs 36/371, P = 0.049). The proportion of mental health presentations due to anxiety, depression and other non‐self‐harm/overdose complaints decreased by 10% (371/564 vs 207/371, P = 0.002). The proportion of overdoses of paracetamol and ibuprofen increased by 13.4% during lockdown (22/158 vs 35/128, P = 0.005).ConclusionsDuring the COVID‐19 lockdown, both overall ED presentations as well as mental health‐related presentations decreased. There was a relative increase in overdoses and self‐harm, particularly involving paracetamol and ibuprofen.
Proteomic assessment of serum biomarkers of longevity in older men
Authors: Orwoll Eric S. , Wiedrick Jack , Nielson Carrie M. , Jacobs Jon , Baker Erin S. , Piehowski Paul , Petyuk Vladislav , Gao Yuqian , Shi Tujin , Smith Richard D. , Bauer Douglas C. , Cummings Steven R. , Lapidus Jodi ,   for the Osteoporotic Fractures in Men Study (MrOS) Research Group
Published: October 2020

AbstractThe biological bases of longevity are not well understood, and there are limited biomarkers for the prediction of long life. We used a high‐throughput, discovery‐based proteomics approach to identify serum peptides and proteins that were associated with the attainment of longevity in a longitudinal study of community‐dwelling men age ≥65 years. Baseline serum in 1196 men were analyzed using liquid chromatography–ion mobility–mass spectrometry, and lifespan was determined during ~12 years of follow‐up. Men who achieved longevity (≥90% expected survival) were compared to those who died earlier. Rigorous statistical methods that controlled for false positivity were utilized to identify 25 proteins that were associated with longevity. All these proteins were in lower abundance in long‐lived men and included a variety involved in inflammation or complement activation. Lower levels of longevity‐associated proteins were also associated with better health status, but as time to death shortened, levels of these proteins increased. Pathway analyses implicated a number of compounds as important upstream regulators of the proteins and implicated shared networks that underlie the observed associations with longevity. Overall, these results suggest that complex pathways, prominently including inflammation, are linked to the likelihood of attaining longevity. This work may serve to identify novel biomarkers for longevity and to understand the biology underlying lifespan.
Chronic opioid exposure differentially modulates oxycodone self‐administration in male and female rats
Authors: Mavrikaki Maria , Lintz Tania , Constantino Nick , Page Sarah , Chartoff Elena 
Published: October 2020

AbstractWithdrawal from opioid painkillers can produce short‐lived physical symptoms and protracted psychological symptoms including anxiety and depressive‐like states that often lead to opioid misuse and opioid use disorder (OUD). Studies testing the hypothesis that opioid withdrawal potentiates the reinforcing effects of opioid self‐administration (SA) are largely inconclusive and have focused on males. Although some clinical evidence indicates that women are more likely than men to misuse opioids to self‐medicate, preclinical studies in both sexes are lacking. Based on clinical reports, we hypothesized that withdrawal from escalating‐dose morphine injections that approximates a prescription painkiller regimen would lead to increased oxycodone SA to a greater extent in female compared to male rats. After escalating‐dose morphine (5–30 mg/kg or vehicle, twice/day for 12 days), rats underwent a 2‐week abstinence period during which withdrawal signs were measured. The impact of this treatment was assessed on oxycodone SA acquisition, maintenance, dose response, and progressive ratio responding, with additional analyses to compare sexes. We found that both sexes expressed somatic withdrawal, whereas only males demonstrated hyperalgesia in the warm water tail flick assay. During SA acquisition, males with prior morphine exposure took significantly more oxycodone than females. Finally, females with prior morphine exposure demonstrated the lowest motivation to SA oxycodone in the progressive ratio test. Contrary to our initial hypothesis, our findings suggest that prior opioid exposure increases vulnerability to initiate misuse more in males and decreases the reinforcing efficacy of oxycodone in females.
Prognostic performance of qSOFA in oncology patients admitted to the emergency department with suspected infection
Authors: Koh Tze Lui , Canet Emmanuel , Amjad Sobia , Bellomo Rinaldo , Taylor David , Gan Hui K. , Marhoon Nada , Lim Andrew , Ong Wee Loon , Krishnan Vivek , Khor Richard 
Published: October 2020

AbstractAimWe aimed to test the performance of the quick Sequential Organ Failure Assessment score (qSOFA) in predicting the outcomes of oncology patients admitted to the emergency department (ED) with suspected infection.MethodsRetrospective cohort analysis of all oncology patients presenting to the ED of a tertiary hospital with suspected infection from 1 December 2014 to 1 June 2017. Patients were identified by cross‐linkage of ED and Oncology electronic health records. The primary outcome was in‐hospital mortality and/or ICU stay ≥ 3 days.ResultsA total of 1655 patients were included in this study––1267 (76.6%) with solid tumor and 388 (23.4%) with hematological malignancies. At presentation, 495 patients had chemotherapy, and 140 had radiotherapy within the preceding 6 months. Four hundred patients received chemotherapy and/or radiotherapy in the previous 4 weeks. Overall, 371 (22.4%) patients had qSOFA ≥ 2. Such patients had a higher likelihood of respiratory infections compared to patients with a qSOFA < 2 (43.9% vs 29%) and were more likely to be admitted to ICU or require mechanical ventilation. In‐hospital mortality or in‐hospital mortality and/or ICU stay ≥ 3 days were 17.3% and 21%, for qSOFA ≥ 2 patients versus 4.7% and 6.9% for qSOFA < 2 patients (P < .001). qSOFA ≥ 2 had a negative predictive value of 95% for in‐hospital mortality and 93% for in‐hospital mortality or ICU stay ≥ 3 days.ConclusionAmong oncology patients presenting to the ED with suspected infection, a qSOFA ≥ 2 is associated with a threefold risk of hospital mortality/prolonged ICU stay. Its absence helps identify low‐risk patients.
LINC01133 promotes the progression of cervical cancer via regulating miR‐30a‐5p/FOXD1
Authors: Zhang Dan , Zhang Yuyang , Sun Xiuyun 
Published: October 2020

AbstractBackgroundThe prognosis of patients with recurrent or metastatic cervical cancer (CC) remains poor, and its incidence is especially high in developing countries. Multiple long noncoding RNAs are recently identified as crucial oncogenic factors or tumor suppressors. In this study, we explored the function and mechanism of LINC01133 during the progression of CC.MethodsExpression levels of LINC01133 and miR‐30a‐5p in 50 CC tissue samples were measured using quantitative real‐time polymerase chain reaction. Immunohistochemistry and Western blot analysis were used to detect the expression of oncogene forkhead box D1 (FOXD1). The association between pathological indices and the expression level of LINC01133 was also analyzed. Human CC cell lines HeLa and SiHa were used as cell models. CCK‐8 and bromodeoxyuridine assays were used to assess the effect of LINC01133 on CC cell line proliferation. Flow cytometry was used to study the effect of LINC01133 on CC apoptosis. Transwell assay was conducted to detect the effect of LINC01133 on migration and invasion. Furthermore, luciferase reporter assay was used to confirm the targeting relationship between miR‐30a‐5p to LINC01133.ResultsWe observed that LINC01133 expression in CC clinical samples was significantly increased, with high expression associated with higher T stage and negative HPV infection of the patients. Its overexpression remarkably accelerated proliferation and metastasis of CC cells, with reduced apoptosis. LINC01133 knockdown suppressed the malignant phenotypes of CC cells. Overexpression of LINC01133 significantly reduced the expression of miR‐30a‐5p by sponging it and enhanced the expression of FOXD1.ConclusionsWe report the overexpression of LINC01133 in CC sample and cell lines, which correlated with unfavorable pathological indices. LINC01133 was a sponge of tumor suppressor miR‐30a‐5p, and it enhanced the expression of FOXD1 indirectly and functioned as an oncogenic lncRNA in CC.