bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective cohort study of immediate implant placement into posterior compromised sockets with or without primary wound closure of reactive soft tissue
Authors: Liu Yeyu , Chen Yilin , Chu Chenyu , Qu Yili , Xiang Lin , Man Yi 
Published: November 2019

AbstractBackgroundConventional wisdom states that reactive soft tissue consisting of granulation tissue and long junctional epithelium in compromised sites should be curetted completely, while others approve of its preservation in implant surgeries.PurposeTo evaluate the presence of reactive soft tissue as wound closure for immediate implantation in posterior compromised sockets.Materials and MethodsThirty‐three implants were included in this study: (a) experimental group (EG), the reactive soft tissue was raised as the primary wound closure for the implant; (b) control group (CG), the reactive soft tissue was also elevated but failed to cover the site. Implants were inserted immediately after the tooth extraction. The bone dimensional changes were observed instantly after surgery (T1) and 6 months later (T2) by cone beam computed tomography. Soft tissue alterations were evaluated before tooth extraction (T0), at prosthesis delivery and at 1‐year follow‐up (T3). Measurements of marginal bone level (MBL) was obtained at the time of prosthesis placement and at T3.ResultsIn all, 100% implant survival was reported during the study period. The buccal bone height and width of keratinized mucosa decreased less in the EG compared to the CG. At the 1‐year follow‐up, MBL and soft tissue changes were not significantly different between the two groups.ConclusionsWithin the limitations of this study, the presence of reactive soft tissue as primary closure may contribute to hard‐soft tissue augmentation during immediate implants into posterior compromised sockets.
Optimization of material removal rate in wire EDM by polynomial neural network models
Authors: Dutta Prasenjit , Majumder Mrinmoy , Panja Subhash Chandra 
Published: November 2019

AbstractMaximization of material removal rate may yield impractical results if the cost for generation of removal rate is not included in the optimization. Presently, there are many studies which have applied different linear, nonlinear, and metaheuristics optimization techniques to maximize material removal rate but none of the approaches have the capability of self‐adaptation. In none of these studies impact of cost on removal rate was considered. That is why, in the present study, the Group Method of Data Handling which is a technique to develop polynomial neural network (PNN) models was utilized for the first time to maximize material removal rate with the help of the on‐ and off‐stage current as the design variables constrained by the operating costs. The PNN architecture is widely used in many fields of technology and science. However, application of this architecture is scarce in case of optimization of material removal rate. According to the results the accuracy level and time of convergence in case of PNN was found to be better compared to that from artificial neural network and linear models both of which were utilized for estimation of the output variable.
Deletion of Ck2β gene causes germ cell development arrest and azoospermia in male mice
Authors: Liang Qiu‐Xia , Wang Zhen‐Bo , Lei Wen‐Long , Lin Fei , Qiao Jing‐Yi , Filhol‐Cochet Odile , Boldyreff Brigitte , Schatten Heide , Sun Qing‐Yuan , Qian Wei‐Ping 
Published: November 2019

AbstractObjectivesIn humans, non‐obstructive azoospermia (NOA) is a major cause of male infertility. However, the aetiology of NOA is largely unknown. Previous studies reported that protein CK2β was abundantly and broadly expressed in spermatogenic cells. Here, we investigate whether protein CK2β participates in spermatogenesis.Materials and MethodsIn this study, we separated spermatogenic cells using STA‐PUT velocity sedimentation, analysed the expression pattern of protein CK2β by immunoblotting, specifically deleted Ck2β gene in early‐stage spermatogenic cells by crossing Ck2βfl mice with Stra8‐Cre+ mice and validated the knockout efficiency by quantitative RT‐PCR and immunoblotting. The phenotypes of Ck2βfl/Δ;SCre+ mice were studied by immunohistochemistry and immunofluorescence. The molecular mechanisms of male germ cell development arrest were elucidated by immunoblotting and TUNEL assay.ResultsAblation of Ck2β gene triggered excessive germ cell apoptosis, germ cell development arrest, azoospermia and male infertility. Inactivation of Ck2β gene caused distinctly reduced expression of Ck2α′ gene and CK2α′ protein.ConclusionsCk2β is a vital gene for germ cell survival and male fertility in mice.
The evaluation of right ventricular systolic function in patients with repaired Tetralogy of Fallot by conventional echocardiographic methods and speckle tracking echocardiography: Compared with the gold standard cardiac mangenetic resonance
Authors: Kavurt Ahmet Vedat , Paç Feyza Ayşenur , Koca Serhat , Mutlu Mıhçıoğlu Ajda , Yiğit Hasan 
Published: November 2019

AbstractBackgroundRight ventricular (RV) function is one of the important prognostic factors in patients with repaired Tetralogy of Fallot (TOF). We aimed to assess RV function by conventional echocardiography and two‐dimensional speckle tracking echocardiography (2D‐STE) in patients with repaired TOF.MethodsTwenty‐seven (male 17) adolescents and young adult patients (mean age 22.7 ± 6.7 years) operated on for TOF and age‐ and gender‐matched healthy controls were included. RV systolic function in both groups were evaluated by fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE), RV myocardial performance index (RVMPI) and tricuspid annular peak systolic velocity by pulsed tissue Doppler (tricuspid S'), and also RV global longitudinal strain (RV GLS) obtained from STE. These results were compared with RV ejection fraction (RVEF) measured by cardiac magnetic resonance imaging (CMRI) performed within 3 months in patient group.ResultsSystolic RVGLS values were significantly lower in patients compared to controls (−17.4 ± 3.1% vs −25.6 ± 3%). Among the echocardiographic parameters, RVGLS had the best correlation with RV EF derived from CMRI (r: −.6). By receiver operating characteristics analysis (ROC), an RV GLS cutoff value of −17.4% had 75% sensitivity and 68.4% specificity in identifying RVEF <45% with an area under curve 0.743 (P < .05). The intra‐ and inter‐observer agreement for RV GLS was excellent.ConclusionRVGLS is an easy, effective, feasible, and reproducible tool in the evaluation of RV systolic function. So, RVGLS measurement by STE may be one of the routine echocardiographic parameters in the evaluation of RV systolic function in patients with repaired TOF.
The evaluation of diastolic function and myocardial performance index during pregnancy: A tissue Doppler echocardiography study
Authors: Gungoren Fatih , Tanriverdi Zulkif , Besli Feyzullah , Barut Mert Ulas , Tascanov Mustafa Begenc 
Published: November 2019

AbstractBackgroundThe pregnancy process is characterized by several changes in the cardiovascular system, especially in left ventricle (LV) systolic and diastolic function. Tissue Doppler imaging (TDI) is a useful tool to evaluate global LV function. This study investigated changes in LV functions using TDI in third‐trimester pregnant women.MethodsA total of 86 consecutive third‐trimester healthy pregnant women and 40 age‐matched nonpregnant healthy women (control group) were enrolled in this cross‐sectional study. LV diameter, standard Doppler and tissue Doppler parameters, and myocardial performance index (MPI) were measured for all patients.ResultsThere was no significant difference in baseline characteristics between the pregnant and control groups. However, the cardiac chamber diameter was larger, the Am velocity was higher, and the E velocity, Em velocity, and E/A ratio were lower in the pregnant group. In addition, the MPI was significantly higher in the pregnant group compared to the control group (0.57 ± 0.11 vs 0.42 ± 0.02, P < .001). Correlation analysis showed that gestational week was positively correlated with the MPI (r = .407, P = .003).ConclusionsDetailed assessment of cardiac function is important during pregnancy. We demonstrated that pregnancy was associated with a significantly increased MPI, as well as structural and functional changes.
Congenital aneurysm of the left atrium associated with double‐outlet right ventricle in a trisomy‐18 fetus: Case report and literature review
Authors: Wang Yi‐Bin , Fu Yi‐Mei 
Published: November 2019

AbstractCongenital aneurysm of the left atrium is a rare cardiac anomaly, most commonly detected between the 2nd and 4th decades of life in a symptomatic patient. We report a congenital aneurysm of the left atrium diagnosed at 24 weeks of gestational age, associated with other congenital heart diseases and 47XY, +18 karyotype. The literature of the left atrial aneurysm diagnosed by fetal echocardiography is also reviewed in this report.
Carotid artery blood velocity decreases in patients with coronary slow flow: A manifestation of systemic arteriosclerosis
Authors: Dong Rui , Lv Qian , Gao Yannan , He Caiyun , Tan Siyuan , Zhang Mingyu , Zhou Tao 
Published: November 2019

AbstractObjectivesCoronary slow flow phenomenon (CSFP) could be a manifestation of systemic arteriosclerosis, as coronary and carotid arteries have similar intimal thickening. However, as an initial cause of arteriosclerosis, hemodynamic changes in carotid arteries have rarely been studied.MethodsTwenty patients with angiography‐proven CSFP and 39 patients with normal coronary flow (NCF) were enrolled. TIMI frame counts (CTFC) were investigated. Carotid intima‐media thickness (CIMT), peak systolic velocity (PSV), and end‐diastolic velocity (EDV) were measured by ultrasonography, and shear rate (SR) and resistance index (RI) were calculated.ResultsThe results showed that PSV, EDV, SR, and RI were significantly lower in patients with CSFP (p＜0.01), but CIMT was significantly increased (P ＜ 0.01). PSV, EDV, SR, and RI were negatively correlated with CTFC, while CIMT was positively correlated with CTFC. Logistic regression analysis revealed that PSV (OR = 0.95, P < 0.01) could be an independent protective factor against CSFP, but CIMT (OR = 1.10, P ＜ 0.05) and male gender (OR = 9.89, P ＜ 0.01) could be risk factors for CSFP.ConclusionsThe slow flow phenomenon was observed in both coronary and carotid arteries, which could be a characteristic manifestation of systemic arteriosclerosis in CSFP; the lower wall shear stress may be the underlying mechanism. Carotid ultrasound could be applied in the noninvasive diagnosis of CSFP in the future.
Myocardial deformation and acute cellular rejection after heart transplantation: Impact of inter‐vendor variability in diagnostic effectiveness
Authors: Ruiz‐Ortiz Martín , Rodriguez‐Diego Sara , Delgado Mónica , Kim Jiwon , Weinsaft Jonathan W. , Ortega Rosa , Carnero Lucía , Sánchez José J. , Carrasco Francisco , López‐Aguilera José , López‐Granados Amador , Arizón José M. , Paredes Nick , Oneto‐Fernandez Jesús , Pan Manuel , Mesa Dolores 
Published: November 2019

AbstractPurposeOur objective was to investigate the impact of inter‐vendor variability in the ability of myocardial strain analysis to detect acute cellular rejection (ACR) in heart transplant recipients.MethodsWe performed serial echocardiographic examinations in 18 consecutive adult heart transplanted patients, in their first year post‐transplantation, within 3 hours of the routine surveillance endomyocardial biopsies (EMB) in a single center. Myocardial strain was analyzed using two software in two different institutions, and inter‐vendor variability of strain values and its association with ACR (any grade or grade ≥2R) was investigated. The parameter of comparison was the peak value of the average curve of strain during the entire cardiac cycle.ResultsA total of 147 pairs of EMB‐echocardiogram were performed, 65 with no ACR, 63 with ACR grade 1R, and 19 with ACR grade ≥2R. Intra‐class correlation coefficients for left ventricle longitudinal, radial, and circumferential strain were 0.38, 0.39, and 0.77, respectively, and 0.32 for right ventricular longitudinal strain. Neither software found significant association of left ventricular longitudinal strain with rejection. Grade ≥2R ACR was associated with left ventricular circumferential strain measured with the first software and with left ventricular radial strain with the other; and ACR of any grade was only significantly associated with right ventricle longitudinal strain measured with the first software.ConclusionsInter‐vendor reproducibility of strain values was low in this study. Some strain parameters were associated to ACR, although these results were inconsistent between two commercially available software. Specific validation of each software is warranted for this clinical indication.
Rapid decreases in relative testes mass among monogamous birds but not in other vertebrates
Authors: Baker Joanna , Humphries Stuart , Ferguson‐Gow Henry , Meade Andrew , Venditti Chris 
Published: November 2019

AbstractLarger testes produce more sperm and therefore improve reproductive success in the face of sperm competition. Adaptation to social mating systems with relatively high and low sperm competition are therefore likely to have driven changes in relative testes size in opposing directions. Here, we combine the largest vertebrate testes mass dataset ever collected with phylogenetic approaches for measuring rates of morphological evolution to provide the first quantitative evidence for how relative testes mass has changed over time. We detect explosive radiations of testes mass diversity distributed throughout the vertebrate tree of life: bursts of rapid change have been frequent during vertebrate evolutionary history. In socially monogamous birds, there have been repeated rapid reductions in relative testes mass. We see no such pattern in other monogamous vertebrates; the prevalence of monogamy in birds may have increased opportunities for investment in alternative behaviours and physiologies allowing reduced investment in expensive testes.
Poly(ADP‐ribose) polymerase‐1 depletion enhances the severity of inflammation in an imiquimod‐induced model of psoriasis
Authors: Kiss Borbála , Szántó Magdolna , Hegedűs Csaba , Antal Dóra , Szödényi Annamária , Márton Judit , Méhes Gábor , Virág László , Szegedi Andrea , Bai Péter 
Published: November 2019

AbstractPoly(ADP‐ribose) polymerase‐1 (PARP1) is a pro‐inflammatory protein, whose pro‐inflammatory properties were demonstrated in human. The pro‐inflammatory properties of PARP1 were shown in Th1‐ and Th2‐mediated inflammatory pathologies, but not Th17‐mediated inflammation. Thus, we studied the role of PARP1 in the imiquimod‐induced model of psoriasis. To our surprise, in imiquimod‐induced psoriasis, PARP1 acted as an anti‐inflammatory factor and its genetic deletion exacerbated symptoms. We showed that in the absence of PARP1, the epidermis thickened and the number of TUNEL‐positive cells decreased in the epidermis. These data indicate programmed cell death is decreased in keratinocytes. Changes in involucrin expression suggest that keratinocyte differentiation is hampered. Furthermore, epidermal expression of IL6 increased in the psoriasiform lesions of PARP1 knockout mice, suggesting that the inflammatory response is also derailed in the absence of PARP1. Finally, we showed that PARP1 expression is reduced in human psoriatic lesions compared with control skin samples. In imiquimod‐treated HPV‐KER keratinocytes, PARP inhibition recapitulated the in vivo findings, namely keratinocyte hyperproliferation; furthermore, the mRNA expression of psoriasis‐associated cytokines (IL6, IL1β, IL8, IL17 and IL23A) was also induced. The inhibition of TRPV1 abrogated the effects of the combined imiquimod + PARP inhibitor treatment.
Living with Uncertainty: Perceptions of Well‐being Among Latinx Young Adults in Immigrant Family Systems
Authors: Daftary Ashley‐Marie Hanna 
Published: November 2019

ObjectiveTo examine how the citizenship and immigrant statuses of Latinx young adults and their families affect their experience.BackgroundScholarship suggests that U.S. policies negatively impact the financial, academic, relational, and emotional well‐being of unauthorized immigrants and their entire family.MethodEighteen Latinx young adults (18–29 years of age) living in immigrant families described their experience through a semi‐structured interview process. Responses were analyzed using thematic analysis at the semantic level.ResultsAn overarching level of uncertainty in relation to immigration status negatively impacted participants' emotional well‐being. These uncertainties were most related to changes in immigration status, the unpredictability of the Deferred Action for Childhood Arrivals (DACA) policy, and the potential for the detention or deportation of unauthorized immigrant family members.ConclusionImmigrant status is often accompanied by a level of unpredictability that negatively impacts emotional well‐being.ImplicationsTo minimize this uncertainty, immigration reform should include a pathway toward U.S. citizenship. Future research related to immigrant families should consider the immigration status of nuclear family members when exploring outcomes for well‐being.
Molecular epidemiologic and clinical analysis of Helicobacter cinaedi bacteremia in Japan
Authors: Nukui Yoko , Chino Takashi , Tani Chihiro , Sonobe Kazunari , Aiso Yoshibumi , Tohda Shuji , Koike Ryuji , Saito Ryoichi 
Published: November 2019

AbstractBackgroundHelicobacter cinaedi is an important pathogen that causes bloodstream infections. Owing to the challenges in its culture and identification, its clinical and bacterial characteristics remain unknown. Our study aimed to investigate the molecular epidemiology and antimicrobial susceptibility of H cinaedi.Materials and MethodsFrom 2003 to 2016, we analyzed 16 non‐repetitive H cinaedi strains, isolated from blood, at the medical hospital of Tokyo Medical and Dental University. Multilocus sequence typing was performed to analyze the genetic relationship across the different isolates. The minimum inhibitory concentrations (MIC) of antibiotics were determined by the agar dilution method.ResultsThe median age of subjects in this study was 61 years (range, 18‐84 years). The most common risk factors included the use of steroids (75.0%) and immunosuppressant drugs (37.5%). In addition, the most common symptoms of H cinaedi bacteremia included colitis (37.5%) and cellulitis (31.3%). The infection recurred in three of seven cases (42.8%) that underwent antibiotic therapy for <10 days. The strains were classified into five sequence types (ST), of which, ST 10 (43.8%) and ST 4 (31.3%) were predominant. The MIC90 values of amoxicillin, gentamycin, imipenem, ciprofloxacin, and clarithromycin were 4, 0.5, 0.25, 64, and 128 mg/L, respectively.ConclusionsSince there is no recommended guideline yet for the choice or duration of antibiotic therapy and antimicrobial break points, our results suggested, for the first time, that prolonged antibiotic therapy, except with ciprofloxacin and clarithromycin, would be required to ensure resolution of symptoms and prevention of recurrence.
Effect of the presence of ethyl lauroyl arginate on the technological properties of edible fish gelatin films
Authors: Otero‐Tuárez Victor , Fernández‐Pan Idoya , Ignacio Maté Juan 
Published: November 2019

SummaryPhysical, chemical and antimicrobial properties of fish gelatin films with different concentrations of ethyl lauroyl arginate (LAE) were studied. Optical properties of film‐forming solution did not vary with increased LAE content. However, pH and surface tension increased. The incorporation of LAE into the formulation increased moisture and solubility of the films. In addition, the presence of LAE affected mechanical properties, making films stronger and more flexible; it had no effect on water vapour permeability. Finally, films with LAE significantly increased antimicrobial properties against Listeria innocua, Shewanella putrefaciens and Pseudomonas fluorescens, but not against Aeromonas hydrophila. These antimicrobial films could be used as an alternative technology for extending shelf‐life of fresh fish products.
FinTech, BigTech, and the Future of Banks
Authors: Stulz René M. 
Published: November 2019

Banks are unique financial institutions in that they combine the production of liquid claims—that is, demand deposits—with loans. Though banks can replicate most of what FinTech firms can do, FinTech firms benefit from an uneven playing field in that they are less regulated than banks. The uneven playing field enables nonbank FinTech firms to challenge banks in specific product areas where success is not tied to what makes banks unique—namely, their deposit‐gathering abilities and the potential for synergies with borrowers provided by deposits. And although banks’ responses to FinTech have also been hampered by their legacy IT systems and by internal frictions inherent in large diversified firms, FinTech's narrow product offerings and lack of established “franchises” appear to put clear limits on Fintech's ability to displace banks.Unlike Fintech, however, BigTech firms have some advantages that banks will find it harder to replicate, and so they present a much stronger challenge to established banks in two main areas: consumer finance and loans to small firms. And FinTech as well as BigTech are contributing to a trend in which banks are losing a comparative advantage that has derived from having more immediate access to information about parties seeking credit. The extent to which banks succeed in warding off such threats will depend on (1) their ability to make effective—and possibly even better—use of the same information technology now being used by its new competitors, and (2) their success in realizing economies of scale and scope that their nonbank competitors will find hard to match.
miR‐148a suppresses inflammation in lipopolysaccharide‐induced endometritis
Authors: Jiang Kangfeng , Yang Jing , Yang Chao , Zhang Tao , Shaukat Aftab , Yang Xiaoyan , Dai Ailing , Wu Haichong , Deng Ganzhen 
Published: November 2019

AbstractEndometritis is a postnatal reproductive disorder disease, which leads to great economic losses for the modern dairy industry. Emerging evidence indicates that microRNAs (miRNAs) play a pivotal role in a variety of diseases and have been identified as critical regulators of the innate immune response. Recent miRNome profile analysis revealed an altered expression level of miR‐148a in cows with endometritis. Therefore, the present study aims to investigate the regulatory role of miR‐148a in the innate immune response involved in endometritis and estimate its potential therapeutic value. Here, we found that miR‐148a expression in lipopolysaccharide (LPS)‐stimulated endometrial epithelial cells was significantly decreased. Our results also showed that overexpression of miR‐148a using agomiR markedly reduced the production of pro‐inflammatory cytokines, such as IL‐1β and TNF‐α. Moreover, overexpression of miR‐148a also suppressed NF‐κB p65 activation by targeting the TLR4‐mediated pathway. Subsequently, we further verified that miR‐148a repressed TLR4 expression by binding to the 3′‐UTR of TLR4 mRNA. Additionally, an experimental mouse endometritis model was employed to evaluate the therapeutic value of miR‐148a. In vivo studies suggested that up‐regulation of miR‐148a alleviated the inflammatory conditions in the uterus as evidenced by H&E staining, qPCR and Western blot assays, while inhibition of miR‐148a had inverse effects. Collectively, pharmacologic stabilization of miR‐148a represents a novel therapy for endometritis and other inflammation‐related diseases.