bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telephone-Based, Clinician-Guided Self-Help Cognitive Behavioral Therapy for Depression in Parkinson's Disease (dPD): The Responder Cases of "Alice" and "Carl," and the Nonresponder Cases of "Ethan" and "Gary"
Authors: Durland Logan 
Published: July 2020

Roseanne Dobkin and her colleagues (e.g., Dobkin, Interian, Durland, Gara, & Menza, 2018) have developed a 10-session, individual cognitive-behavioral treatment (CBT) program for treating depression in individuals with Parkinson’s disease (dPD). The program has been found to yield statistically and clinically significant success in both uncontrolled group trial designs and randomized clinical trials—originally in a face-to-face version, and then in a telehealth version, using telephone therapy sessions and guided self-help materials for patients. This latter version is herein called "Teleheath Guided Self-Help for dPD," or "TH-GSH-dPD," for short. Applying Fishman, Messer, Edwards, and Dattilio’s (2017) "case studies within psychotherapy trials" methodological model, the present research was designed to complement the group research findings by my conducting systematic, pragmatic case studies (Fishman, 2013) with four patients representative of those in the telehealth studies, given the names of "Alice" (and her caregiver husband "Bob"); "Carl" (and his caregiver wife "Doris"); "Ethan" (and his caregiver wife, "Fay"); and "Gary" (and his caregiver mother, not named). Specifically, Alice and Carl were representative of those patients in the group studies with positive, responsive outcomes; and Ethan and Gary were representative of those patients in the group studies with negative, nonresponsive outcomes. Each case combines (a) quantitative data, comprised of demographic information, psychiatric diagnostic data, neurocognitive data, caregiver distress, and treatment outcome measures; and (b) qualitative data, consisting of recordings of the telephone therapy sessions, my treatment notes, my observations as the therapist, and systematic, post-treatment "Exit Interviews" I conducted with each of the patients and their caregivers about their therapy experience. Each of the four case studies aims (a) to provide a detailed, thickly described portrait of the TH-GSH-dPD treatment process; and (b) to explore the presence and influence of barriers and facilitators of treatment in an idiographic context. Regarding point (b), the following variables that cut across the case studies are explored as appearing to be particularly impactful: patients’ worldviews, patients’ cognitive functioning, caregiver involvement, and homework adherence.
Lessons Learned: Conducting Cases of Manualized, Telephone-Based, Cognitive Behavioral Treatment for Depression in Parkinson’s Disease (dPD)
Authors: Durland Logan 
Published: July 2020

My current clinical practice has been shifted to a telehealth format for the last three months due to the COVID-19 pandemic, and it seems an apt moment to reexamine my participation in Dr. Roseanne Dobkin’s research on manualized telehealth therapy for depression in Parkinson’s disease patients (dPD), using a protocol titled "Teleheath Guided Self-Help for dPD," or "TH-GSH-dPD," for short (Dobkin et al., 2020). My participation involved, in part, being the therapist in four case studies I have written about with "Alice," "Carl," "Ethan," and "Gary" (Durland, 2020). In these case studies, a subset of those in Dr. Dobkin’s group studies, I explored my clinical decision-making, seeking insight into how best to flexibly apply the dPD protocol to meet the needs of a heterogeneous clinical population. Here, my aim is to recontextualize and expand on the conclusions of my four case studies, based on my dissertation and conducted over three years ago (Durland, 2017), in light of both my recent experience providing mental health services and the Commentaries on the four case studies so perceptively contributed by Dr. Dobkin and her colleagues (Mann, Miller, St. Hill, & Dobkin, 2020) and by Liza Pincus (2020). In particular, I will focus first on (a) continuing the analysis of clinical decision-making involved in the case studies described in my earlier article (Duland, 2020); and then on (b) general issues related to the delivery of telehealth treatment.
On the Constraint Factor Relating Uniaxial and Indentation Yield Strength of Polycrystalline Materials Using Spherical Microindentation
Authors: Bhat Anirudh , Neu R. W. 
Published: July 2020

Abstract
High-throughput (HT) material property characterization has become increasingly important for the rapid and cost-effective development of new material systems. In recent years, spherical indentation using the Pathak-Kalidindi (P-K) protocol has been shown to be a reliable and HT method for capturing the elastic-plastic properties of several different types of materials. However, because of the higher hydrostatic pressure under the indenter tip and the constraint of the surrounding elastically deforming material, the indentation yield strength is higher than the uniaxial yield strength and they can be related by a scaling factor, referred to as the constraint factor. For fully plastic indentation, the constraint factor was found by Tabor to be ~2.8. However, the constraint factor is not well defined for elastic-plastic indentation and depends on the strain induced. In this work, the application of the P-K indentation protocol is demonstrated on a set of aluminum 7050 samples that have undergone different solution and aging treatments. Conventional uniaxial tensile and compression tests were also conducted on the same material. The constraint factor at the 0.2 % offset yield point was determined from the indentation and uniaxial measurements to be ~1.4. Experimental observations from our work and a similar work on aluminum 6061 showed a dependence of the constraint factor at the 0.2 % offset yield point on the uniaxial plastic properties. To explain these experimental observations, further investigation was carried out using finite element simulations of spherical indentation on materials with different yield strengths and hardening parameters. New insights are provided on the constraint factor at the 0.2 % yield point, which show that it increases with the ratio of the plastic to elastic strain. It was also found that the effect of the hardening is much less than that of the yield strength on the constraint factor at the 0.2 % yield point.
Team–based Learning of Sustainability: Incorporation of Sustainability Concept and Assessment into Chemical Engineering Senior Design Course
Authors: Amini-Rankouhi Aida , Huang Yinlun 
Published: July 2020

Abstract
Design for Sustainability (DfS) becomes as an increasing important component in engineering education. One of the most effective educational strategies for sustainability integration is through undergraduate senior capstone courses. Chemical engineering as a main engineering discipline aims to prepare next-generation engineers with adequate knowledge and skills for pursing sustainable engineering in the near future. In this paper, we introduce our approach for introducing sustainability concepts and sustainability assessment methods into our undergraduate capstone design course. In the course, we guided students to conduct a sophisticated team project: Process Design, Modification, and Sustainability Assessment for Distributed Biodiesel Manufacturing. Students in teams developed and evaluated all design options from the sustainability point of view using different sustainability metrics systems and discussed for identification of most desirable solutions. Educational experience with the team-based approach was summarized through classroom evaluation.
T-Type Calcium Channels Contribute to Burst Firing in a Subpopulation of Medial Habenula Neurons
Authors: Vickstrom Casey R. , Liu Xiaojie , Zhang Yuqi , Mu Lianwei , Kelly Thomas J. , Yan Xudong , Hu Meng-ming , Snarrenberg Shana T. , Liu Qing-song 
Published: July 2020

AbstractAction potential (AP) burst firing caused by the activation of low-voltage-activated T-type Ca2+channels is a unique mode of neuronal firing. T-type channels have been implicated in diverse physiological and pathophysiological processes, including epilepsy, autism, and mood regulation, but the brain structures involved remain incompletely understood. The medial habenula (MHb) is an epithalamic structure implicated in anxiety-like and withdrawal behavior. Previous studies have shown that MHb neurons fire tonic APs at a frequency of ∼2–10 Hz or display depolarized low-amplitude membrane oscillations. Here, we report in C57BL/6J mice that a subpopulation of MHb neurons are capable of firing transient, high-frequency AP bursts mediated by T-type channels. Burst firing was observed following rebounding from hyperpolarizing current injections or during depolarization from hyperpolarized membrane potentials in ∼20% of MHb neurons. It was rarely observed at baseline but could be evoked in MHb neurons displaying different initial activity states. Further, we show that T-type channel mRNA, in particular Cav3.1, is expressed in the MHb in both cholinergic and substance P-ergic neurons. Pharmacological Cav3 antagonism blocked both burst firing and evoked Ca2+currents in MHb neurons. Additionally, we observed high-frequency AP doublet firing at sustained depolarized membrane potentials that was independent of T-type channels. Thus, there is a greater diversity of AP firing patterns in MHb neurons than previously identified, including T-type channel-mediated burst firing, which may uniquely contribute to behaviors with relevance to neuropsychiatric disease.
Electric Field ApplicationIn VivoRegulates Neural Precursor Cell Behavior in the Adult Mammalian Forebrain
Authors: Sefton Elana , Iwasa Stephanie N. , Morrison Taylor , Naguib Hani E. , Popovic Milos R. , Morshead Cindi M. 
Published: July 2020

AbstractDeep brain stimulation (DBS), which uses electrical stimulation, is a well-established neurosurgical technique used to treat neurologic disorders. Despite its broad therapeutic use, the effects of electrical stimulation on brain cells is not fully understood. Here, we examine the effects of electrical stimulation on neural stem and progenitor cells (collectively neural precursor cells; NPCs) from the subventricular zone in the adult forebrain of C57BL/6J mice. Previous work has demonstrated that adult-derived NPCs are electro sensitive and undergo rapid and directed migration in response to application of clinically relevant electric fields (EFs). We examine NPC proliferation kinetics and their differentiation profile following EF application usingin vitroandin vivoassays.In vitrodirect current electrical stimulation of 250 mV/mm is sufficient to elicit a 2-fold increase in the neural stem cell pool and increases neurogenesis and oligogenesis.In vivo,asymmetric biphasic electrical stimulation similarly increases the size of the NPC pool and alters neurogenesis. These findings provide insight into the effects of electrical stimulation on NPCs and suggest its potential use as a regenerative approach to neural repair.
Problem Based Learning Model for Junior High School in Indonesia (2010-2019)
Authors: Faqiroh Binti Zakkiyatul 
Published: July 2020

Problem-based learning model is a learning model emphasizes on solving the problem as a mean to know the students’ thinking skills and bring learning process more meaningful. But there are some problems in the learning that many teachers still relied their learning practices conventionally in which make students often bored and uncomfortable within the classroom. The purpose of this research is revealing the development of learning practices using problem-based learning model of junior high school students in Indonesia in 2010-2019. This research used qualitative approach and the result shown that problem-based learning model has been used widely and has attracted many first high school students to improve their competencies. Therefore, teachers need to create such innovations based on problem-based learning.
Abstrak
Problem-based learning atau pembelajaran berbasis masalah adalah model pembelajaran yang lebih mengedepankan pemecahan masalah untuk dapat mengetahui perkembangan kemampuan berpikir peserta didik dan menjadikan pembelajaran lebih bermakna. Perlu diketahui bahwasnya ada beberapa permasalahan yang terjadi di dalam pembelajaran yaitu masih banyaknya guru yang menggunakan model pembelajaran konvensional yang membuat siswa sering merasa bosan dan tidak nyaman dalam mengikuti pembelajaran. Tujuan penelitian ini adalah untuk mengetahui perkembangan pembelajaran dengan menggunakan model pembelajaran problem-based learning oleh para siswa pada jenjang sekolah menengah pertama di Indonesia pada tahun 2010-2019. Metode yang digunakan adalah metode kualitatif. Hasil yang akan diperoleh adalah model pembelajaran problem-based learning memang banyak digunakan dan lebih diminati oleh siswa sekolah menengah pertama pada tahun 2010-2019. Penelitian ini menggunakan pendekatan kualitatif dan hasilnya menunjukkan bahwa penggunaannya memang banyak pada periode tahun-tahun tersebut dan dikehendaki oleh siswa untuk meningkatkan kompetensi mereka. Oleh karena itu para guru perlu mengembangkan inovasi-inovasi baru problem-based learning ini.
Clinical heterogeneity of hypophysitis secondary to PD-1/PD-L1 blockade: insights from four cases
Authors: Lupi Isabella , Brancatella Alessandro , Cosottini Mirco , Viola Nicola , Lanzolla Giulia , Sgrò Daniele , Dalmazi Giulia Di , Latrofa Francesco , Caturegli Patrizio , Marcocci Claudio 
Published: July 2020

Summary
Programmed cell death protein 1/programmed cell death protein ligand 1 (PD-1/PD-L1) and cytotoxic T-lymphocyte antigen 4/B7 (CTLA-4/B7) pathways are key regulators in T-cell activation and tolerance. Nivolumab, pembrolizumab (PD-1 inhibitors), atezolizumab (PD-L1 inhibitor) and ipilimumab (CTLA-4 inhibitor) are monoclonal antibodies approved for treatment of several advanced cancers. Immune checkpoint inhibitors (ICIs)-related hypophysitis is described more frequently in patients treated with anti-CTLA-4; however, recent studies reported an increasing prevalence of anti-PD-1/PD-L1-induced hypophysitis which also exhibits slightly different clinical features. We report our experience on hypophysitis induced by anti-PD-1/anti-PD-L1 treatment. We present four cases, diagnosed in the past 12 months, of hypophysitis occurring in two patients receiving anti-PD-1, in one patient receiving anti-PD-1 and anti-CTLA-4 combined therapy and in one patient receiving anti-PD-L1. In this case series, timing, clinical presentation and association with other immune-related adverse events appeared to be extremely variable; central hypoadrenalism and hyponatremia were constantly detected although sellar magnetic resonance imaging did not reveal specific signs of pituitary inflammation. These differences highlight the complexity of ICI-related hypophysitis and the existence of different mechanisms of action leading to heterogeneity of clinical presentation in patients receiving immunotherapy.

Learning points:

PD-1/PD-L1 blockade can induce hypophysitis with a different clinical presentation when compared to CTLA-4 blockade.

Diagnosis of PD-1/PD-L1 induced hypophysitis is mainly made on clinical grounds and sellar MRI does not show radiological abnormalities.

Hyponatremia due to acute secondary adrenal insufficiency is often the principal sign of PD-1/PD-L1-induced hypophysitis and can be masked by other symptoms due to oncologic disease.

PD-1/PD-L1-induced hypophysitis can present as an isolated manifestation of irAEs or be in association with other autoimmune diseases
No hay palabra indígena para decir turismo.
Authors: Enriz Noelia 
Published: July 2020

El presente trabajo aborda la complejidad que presenta la creación de áreas naturales protegidas en territorios de ocupación ancestral indígena, especialmente cuando las áreas protegidas se desarrollan como polos del turismo internacional. El estudio discute el caso específico del turismo de gran escala en la zona de Iguazú, en el norte de Argentina. Allí se emplaza el punto turístico de mas relevancia del país, las Cataratas de Iguazú. Esta indagación se enmarca en proyectos de larga duración en la zona, en el marco de metodologías de investigación de tipo histórico-etnográficas. Empíricamente utilizamos fuentes documentales, registros etnográficos y fragmentos de conversaciones. En el plano teórico, apuntamos a contribuir al campo de las reflexiones sobre las industrias extractivas, los conflictos entre medioambiente, conservación e impacto socio-ambiental desde una perspectiva etnográfica centrada en las poblaciones indígenas.
AZ EMLÉKEZÉS HULLÁMAI:EMBER – TÁRSADALOM – KULTÚRA 150 ÉV EMLÉKEZETELMÉLETEIBEN
Authors: PLÉH CSABA 
Published: July 2020

A modern emlékezetkutatás másfél évszázada indult el Hering elméletével, mely először kötötte az emlékezés közismert kulturális gyakorlatát az idegszövet feltételezett átalakulásaihoz. Azóta is vita tárgya, hogy vajon a múlt minden hatását emlékezetnek nevezzük-e, vagy csupán az egykori helyzetek és események visszaidézését. Az előadás kiindulópontja, hogy az emlékezet kutatása azóta három vágányon halad. Keressük a szervezet múltjának neurális nyomait, az emlékezés szerveződését az egyén lelki életében, s a visszaidézések csoport szervezte s csoportteremtő gyakorlataiban a kulturális (akár történeti) emlékezetet nyomozzuk.A hagyományok közti kapcsolatteremtés egyik fogalmi kérdése a „mik vagy kik” az emlékek és az emlékezés hordozói és ágensei? Emlékezik-e a hippokampusz, s emlékeznek-e a kondicionált állatok? Hogyan emlékezhetnek csoportok, miként Halbwachs ma felújított évszázados elmélete sugallja, úgy, hogy közben ne tételezzünk misztikus „csoportlelkeket”. Hogyan használunk emlékezeti erőforrásként másokat, könyveket, könyvtárakat, s keresőmotorokat? Ki végzi ilyenkor az emlékezést, s hová rendelődik a bevésés-tárolás-felidézés klasszikus hármassága?Klasszikus kérdés mindhárom kutatási hagyományban az emlékek és tudások szerveződése. Ismertetőjegyek, helyek, képek, szokások, történetek, eljárások világáról született biológiai, pszichológiai és kulturális elméletek kavalkádja. Bergson óta velünk él az az igény, hogy az emlékeket a személyhez (egóhoz, selfhez) kapcsoljuk, s az ént egyszerre tekintsük mint a test, a személyi élmény és a társas hatás emlékezeti integrációs felületét és ezek működésének eredményét. A mellett érvelek, hogy a jelentésteli emlékek elbeszélő felfogása, amelyet a hazai irodalomban László János képviselt, kapcsolatot tud teremteni a pszichológiai és a kulturális emlékezet, gyakorlatok és kutatási hagyományok között.Mint egy pszichológustól joggal várható is, mondanivalóm az lesz, hogy a C. P. Snow kiemelte két kultúra, de mára akár három kultúra (művészet, bölcsészet, tudomány) örökségében a kísérleti pszichológus hivatása, hogy megteremtse a hidat és párbeszédet ezek között a szétvált társalgási univerzumok között. Saját emlékezetikultusz-személyeink, Ranschburg, Rapaport, Kardos, Grastyán, Mérei és László életműve és nyitott gondolkodása hordozza ezt az igényt mint elkötelező örökséget.
Effect of a Structured Teaching Module Including Intensive Prophylactic Measures on Reducing the Incidence of Capecitabine-Induced Hand-Foot Syndrome: Results of a Prospective Randomized Phase III Study
Authors: Ostwal Vikas , Kapoor Akhil , Mandavkar Sarika , Chavan Neeta , Gupta Tarachand , Mirani Jimmy , Saklani Avanish , Desouza Ashwin , Murugan Kalaivani , Nashikkar Chaitali , Gupta Sudeep , Ramaswamy Anant 
Published: July 2020

Abstract

Lessons Learned
A structured teaching module including intensive prophylactic measures to alleviate hand-foot syndrome (HFS) during capecitabine therapy is feasible but ineffective at protecting patients from HFS. Pharmacologic therapeutic interventions should be investigated for the management of this complication.

Background
Capecitabine-induced hand-foot syndrome (HFS) has a detrimental effect on quality of life. The effect of a structured teaching module including intensive prophylactic measures was evaluated.

Methods
This non-crossover phase III double-blinded clinical trial randomized patients in a 1:1 ratio to either a control group or to a group administered a structured teaching model including intensive prophylactic measures on HFS administered by a trained oncology nurse at regular intervals (case) versus standard information on HFS care administered by treating clinician (control). The primary endpoint was comparison of fraction of patients in both arms developing at least grade 2 HFS.

Results
Between June 15, 2016, and April 4, 2018, 280 patients (140 to case and 140 to control) were enrolled. The median number of capecitabine chemotherapy cycles was eight; 269 patients (96%) were evaluable for HFS, of whom 89 patients (33.08%) developed at least grade 2 HFS (grade 2 HFS, 73 patients [26.1%]; grade 3 HFS, 16 patients (5.7%}). There was no difference in at least grade 2 HFS between evaluable case and control arms of the study (control group, 45/135 [33.3%]; case, 44/134 [32.8%]; p = .93).

Conclusion
The use of a structured teaching module including intensive prophylactic measures was feasible, but this did not reduce the incidence and severity of capecitabine-induced HFS.
Peculiarities of formation of secondary sexual characteristics and menstrual function in girls with hyperandrogenism during puberty
Authors: Talibli A. A. 
Published: July 2020

Aim: to study the peculiarities of the formation of secondary sexual characteristics and menstrual function in girls with hyperandrogenism (HA) during puberty.Materials and methods. We examined 137 adolescent girls with HA aged 12–17 years. All examined girls were divided into 3 groups: 12–13 years (Group I, n = 27); 14–15 years (Group II, n = 63); 16–17 years (Group III, n = 47). The intensity of secondary sexual characteristics was determined by Tanner scale; the severity of hirsutism was assessed by Ferriman–Galway scale. The studied parameters were compared with previously published data from 42 girls without HA symptoms with normal indicators of physical and sexual development that were also divided into 3 age groups: 12–13 years (n = 16), 14–15 years (n = 14), 16–17 years (n = 12).Results. Girls with HA in puberty, starting from 14–15 years, had marked reduction of mammary glands and enhancement of axillary and suprapubic hair growth. In 32.8 % of girls with HA menstrual function was normal; in 67.1 % menses disorders and menstrual irregularities were observed that manifested by opsomenorrhea (31.5 %), juvenile bleedings (19.6 %), oligomenorrhea (18.5 %), amenorrhea (16.3 %), algodismenorrhea (14.1 %).Conclusion. HA in puberty, regardless of origin that caused this pathology, is a high risk factor for pathologies of sexual development and the formation of menstrual dysfunction.
I Am Trying Hard to Follow the Sound: Meditations on Accepting Typhoon's Offerings
Authors: Steeves H. Peter 
Published: July 2020

ABSTRACTThe latest album from indie‐rock band Typhoon, fronted by Kyle Morton, is an existential trip through birth, sleep, love, life, and after‐life. With ties to Greek mythology, surrealist filmmaking, twentieth‐century literature, and the history of philosophy, Offerings is an album that invites the listener to imagine a stream of consciousness that navigates a watery life‐path toward something liberating. This essay traces the conceptual themes at work in the music and lyrics of the album, offering a song‐by‐song analysis of an intricate narrative that unfolds within a work of art that deserves to be recognized as a contemporary masterpiece.