bluuebunny/crossref_metadata_2025_split huggingface dataset:
P091 Factors Predicting Compliance With Passive and Active Monitoring in Inflammatory Bowel Disease Patients
Authors: Singer Jorie , Rai Victoria , Sossenheimer Philip , Karpin Jordan , Rodriguez Tina , Yi Yangtian , Yvellez Olivia , Rubin David 
Published: December 2019

BACKGROUND:
Updated goals of management of IBD patients include monitoring disease activity, yet compliance with such strategies is poorly studied. We are performing a multi-year study of patients with active and quiescent IBD to assess the utility of a wearable, continuously active biosensor and validating disease activity with scheduled stool (calprotectin) and serum (CRP) testing. This study assessed compliance with these passive and active monitoring strategies.

METHODS:
Patients with diagnosed IBD were recruited for a prospective study using a biosensor (Fitbit Alta HR, San Francisco, CA) and mobile application (Litmus Health, Austin, TX). Each patient was instructed to wear a biosensor for a one-year period with stool sample drop-offs and blood draws for the first 6 months. The biosensor collected step count, sleep time, and heart rate during the study. Compliance was calculated as the number of days of heart rate, step count, and sleep data received over the duration of the study measured in days. Compliance was defined as ≥80% data collection in the time studied. A t-test was performed to determine the significant difference (P < 0.05) in compliance based on age, sex, disease activity, and body mass index (BMI); and between day time and night time wear.

RESULTS:
A total of 40 patients were analyzed; 23 men (57.5%), 24 with ulcerative colitis (60%), and 20 in remission (50%). 28 patients were <50 years of age (70%). The average BMI was 26.5 kg/m2. Overall, there was a 78% biosensor compliance rate among IBD patients. 45% of patients in clinical remission were compliant in stool drop-offs, while 60% of patients with clinically active disease were compliant in stool drop-offs (P > 0.05; 95% CI: -14.8 to 41.39). There were significant differences between biosensor compliance at night (57%) and day (98%) (P < 0.01; 95% CI: 0.31 to 0.5) and active disease (P < 0.01; 95% CI: -1.13 to -0.80). There was no significant difference in compliance and sex (P > 0.05; 95% CI: -0.53 to 0.11), age (P > 0.05; 95% CI: -11.14 to 7.84), and BMI (P > 0.05; 95% CI: -3.62 to 5.57). There were insufficient data to analyze compliance in answering questionnaires.

CONCLUSION(S):
In this study, patients were more compliant wearing the biosensor during the day than during the night and were more compliant if they had clinically active disease. In future studies, it will be important to provide an incentive and intervention to promote compliance in both active and passive monitoring strategies.
P096 Cerebral Venous Thrombosis as a Complication of Crohn's Disease
Authors: Tatineni Shilpa , Burch Jacob , Al-Abcha Abdullah , Cherian John , Laird-Fick Heather 
Published: December 2019

BACKGROUND:
Extra-intestinal complications of inflammatory bowel disease are extensive; one well-known but rare complication is the development of thrombo-embolism. Most frequently reported events involve pulmonary or peripheral venous thromboses. We report an unusual case of cerebral venous thrombosis in a female patient with Crohn’s disease.

CASE:
A 52-year-old female with past medical history significant for Crohn’s disease and migraines presented to the hospital with a chief complaint of sudden onset numbness and weakness in her right upper extremity. On the day of admission, she awoke at approximately 5AM with a 10/10 throbbing, frontal headache associated with nausea & photophobia. She went back to sleep and awoke 3 hours later with arm weakness. CT brain without contrast showed an extensive thrombosis of the superior sagittal sinus and bilateral cortical veins with associated intraparenchymal hemorrhage of the left frontal lobe. CT angiography (CTA), magnetic resonance angiography (MRA) and magnetic resonance imaging (MRI) of the brain, performed subsequently, re-demonstrated the prominent sagittal sinus thrombosis with involvement of the right transverse and sigmoid sinuses and mild propagation of the thrombus into the straight sinus. She was started on IV heparin and neurosurgery was consulted. Her handgrip strength slowly improved to 4/5. Inflammatory pro-markers, ESR and CRP were elevated, supporting active Crohn’s inflammation. Genetic testing for inherited thrombophilia were negative. She was ultimately discharged home with warfarin.

DISCUSSION:
Arterial and venous thrombo-embolic events are well documented and sometimes life-threatening complications of inflammatory bowel disease. Cerebral venous thrombosis has been reported rarely, but more often in association with ulcerative colitis than Crohn’s disease. Although the exact mechanism is unknown, the synergistic effects of an inflammatory state combined with transient elevation of coagulation factor levels, endothelial vascular activation, acquired natural anticoagulant deficiencies, increased platelet activation, and increased platelet aggregation have been shown to contribute to the prothrombotic state. Overall, patients with IBD have an approximately 2-fold increased risk for venous thrombo-embolism than the general population (RR, 1.96; 95% CI, 1.67-2.30), and account for 1.6% of all patients with central venous thrombosis. Early recognition and high suspicion of this condition for patients with IBD can help decrease mortality and prevent devastating complications such as hemiparesis, seizures, hydrocephalus, visual loss and dural arteriovenous fistulas. The optimal duration of anticoagulation and the risk for recurrent thrombosis are unclear in this population. Treatment merits careful coordination between gastroenterology, hematology, and neurology.
P111 The Efficacy of Early Treatment in Immune Checkpoint Inhibitor-Related Colitis: Clinical Outcomes in a Retrospective Case Series
Authors: Yutsudo Kazuki , Tanaka Akihito , Komaki Yuga , Iwaya Hiromichi , Arima Shiho , Sasaki Fumisato , Tanoue Shiroh , Hashimoto Shinichi , Kanmura Shuji , Ido Akio 
Published: December 2019

BACKGROUND:
New immunotherapy using immune checkpoint inhibitors plays a critical role in cancer treatment. Immune checkpoint inhibitor-related colitis (irAE-colitis) occurs in approximately 1–20% of cancer patients treated with immune checkpoint inhibitors. There are limited data on the outcomes of optimal treatment in patients with irAE-colitis. The aim of this report was to clarify treatment outcomes for patients with irAE-colitis in our facilities.

METHODS:
Of 676 patients who received immune checkpoint inhibitors at our hospital and related facilities, nine patients who developed irAE-colitis were included. We defined effectiveness as follows: a decrease of 3 points or more in a Mayo endoscopic sub-score, 0 or 1 points in a rectal bleeding score and 2 points or more in a Mayo clinical score.

RESULTS:
The male-to-female ratio was five to four. There were five cases of lung cancer, one case of renal cancer, one of head and neck cancer, one of melanoma, and one of gastric cancer. The immune checkpoint inhibitors pembrolizumab and nivolumab, which are anti-PD-1 antibodies, were used in six and three cases, respectively. The drugs used after onset are as follows. One case was mesalazine, six were steroids, one was infliximab, and one was cyclosporine. The effective rate of steroids was 84% (5/6 cases), of which two cases relapsed during steroid tapering. However, both cases improved with steroid re-administration. For one case where steroids were ineffective, we used infliximab. Although the patient’s condition improved temporarily, we encountered secondary failure and changed to cyclosporine, which was effective. One case died before treatment intervention due to severe diarrhea. Immune checkpoint inhibitors were discontinued in all cases. At the time of writing, six patients are still alive after improvement of abdominal symptoms.

CONCLUSION(S):
Steroid therapy was quite effective for the treatment of irAE-colitis, although early relapse occurred in some cases. Prospective studies are required to define the optimal management of irAE-colitis in order to maintain positive long-term outcomes.
Produção científica docente: estudo sobre as publicações dos cursos de Jornalismo do Tocantins
Authors: Macedo de Sousa Poliana 
Published: December 2019

O presente estudo faz um mapeamento da produção científica dos docentes vinculados aos cursos de Jornalismo no Estado do Tocantins, em três Instituições de Ensino Superior (Universidade Federal do Tocantins - UFT, Centro Universitário Unirg e Ceulp/Ulbra), todos credenciados pelo MEC – Ministério da Educação e que estavam em funcionamento durante os anos de 2006 a 2016. Esse mapeamento foi realizado por meio de análise do Currículo Lattes de cada docente até então vinculado aos cursos. Analisou-se a publicação de artigos em periódicos, livros e/ou capítulos de livros publicados, trabalhos publicados em anais de eventos, resumos publicados em anais de eventos e apresentação de trabalhos em eventos científicos. Com esse mapeamento foi possível identificar o quanto os docentes produziram nesse período e qual o canal de comunicação científico mais utilizado pelos mesmos para a divulgação de sua produção científica.
Palavras-chave: Comunicação Científica. Produção Científica. Jornalismo.
Relatos de niños y niñas, y algo más
Authors: Santamaría Valero Flor Alba 
Published: December 2019

El camino que he recorrido tras la búsqueda y la comprensión de los relatos infantiles tiene su origen, inicialmente, en mi experiencia como profesorade niños en escuelas públicas de Bogotá y, posteriormente, como docente de la Universidad Distrital Francisco José de Caldas, en campos de formación de maestros y de profesionales para la infancia, a nivel de pregrado y posgrado, así como también de la participación en investigaciones relacionadas con el uso lenguaje en aula de clase. Estos espacios me han permitido tener de cercalas voces de los niños, no solo escolarizados sino también, desde otras dimensiones, como lo es el programa de radio Tripulantes, creado desde la Cátedra Unesco en Desarrollo del Niño2, donde cada sábado salen al aire las voces y creaciones de losniños, que desde una radionave simbólica, vuelan y llegan hasta lugares inimaginados.
A Point of Contact Between the Archives of Pompeius Niger and of Tryphon the Weaver?
Authors: Maravela Anastasia , Mangerud Jens 
Published: December 2019

Abstract
This article argues that the name of the aggresive female character mentioned by the sender of the private letter SB VI 9121 is Seraeus, and proposes further that through her this letter connects the family of the veteran of the Roman army L. Pompeius Niger, to whose archive it belongs, with the family of Tryphon the weaver.
Reuniting the Dossier of Flavius Demetrios, an Aristocrat and Landowner in Late Antique Hermopolite
Authors: Giacometti Dario 
Published: December 2019

Abstract
This article presents new evidence that a certain Demetrios, documented in CPR IX 12-19, where he issues orders for delivery, is identical with the megaloprepestatos comes Flavius Demetrios, who lived in the Hermopolite nome during the early 7th century AD and is known from SPP XX 218, P.Laur. II 26 and CPR IV 106.
Challenges of Korean Immigrant Leadership in the Church
Authors: Choi Hee An 
Published: December 2019

Abstract
The article suggests that the practices of leadership within Korean communal transformational leadership in Korean resistance movements provide a resource for women in the Korean immigrant church. The article addresses the challenges of Korean leadership in immigrant contexts, how immigrant leadership is performed and transformed, and how immigrants have developed and adapted their leadership from a Korean to US context during the immigrant identity transformation process.
The Role of Surface Hydroxylation, Lattice Vacancies and Bond Covalency in the Electrochemical Oxidation of Water (OER) on Ni-Depleted Iridium Oxide Catalysts
Authors: Nong Hong Nhan , Tran Hoang Phi , Spöri Camillo , Klingenhof Malte , Frevel Lorenz , Jones Travis E. , Cottre Thorsten , Kaiser Bernhard , Jaegermann Wolfram , Schlögl Robert , Teschner Detre , Strasser Peter 
Published: December 2019

Abstract
The usage of iridium as an oxygen-evolution-reaction (OER) electrocatalyst requires very high atom efficiencies paired with high activity and stability. Our efforts during the past 6 years in the Priority Program 1613 funded by the Deutsche Forschungsgemeinschaft (DFG) were focused to mitigate the molecular origin of kinetic overpotentials of Ir-based OER catalysts and to design new materials to achieve that Ir-based catalysts are more atom and energy efficient, as well as stable. Approaches involved are: (1) use of bimetallic mixed metal oxide materials where Ir is combined with cheaper transition metals as starting materials, (2) use of dealloying concepts of nanometer sized core-shell particle with a thin noble metal oxide shell combined with a hollow or cheap transition metal-rich alloy core, and (3) use of corrosion-resistant high-surface-area oxide support materials. In this mini review, we have highlighted selected advances in our understanding of Ir–Ni bimetallic oxide electrocatalysts for the OER in acidic environments.
Persistencia de la reemergencia de la rabia canina en el sur del Perú
Authors: Recuenco Cabrera Sergio 
Published: December 2019

En el siglo pasado la rabia canina fue endémica en nuestro país. En la década de los 1990's, el Perú implementó el plan de acción para la eliminación de la rabia urbana por recomendación de la Organización Panamericana de la Salud, logrando un control exitoso de la rabia. Pese a los esfuerzos desplegados, Puno mantuvo focos endémicos persistentes, y en el 2014, Arequipa reportó el primer evento de reintroducción de rabia urbana en Latinoamérica. El brote de rabia se intensificó en los últimos años en Arequipa, Puno y Cusco, con 19 casos de rabia canina el 2015, a 59 casos el 2016, continuando el 2017 con 47 casos, el 2018 con 46, y hasta julio del 2019, 17 casos. Así, hubo reintroducción de la rabia canina, estableciendo una situación de alta endemicidad no controlada. En el presente reporte, abordamos el contexto y persistencia de la reemergencia de la rabia canina en el sur del Perú.
Síntesis histórica de estudios biosociales de la coca y la alimentación en Perú, 1948-1994
Authors: Ayala Pío Salomón , Quintana-Salinas Margot 
Published: December 2019

El objetivo del presente artículo es ofrecer una perspectiva histórica de investigaciones sobre cocaísmo y alimentación en el hombre andino durante la segunda mitad del siglo XX. El hábito del cocaísmo fue considerado un importante problema de salud pública del Perú en los 40s, cuando el debate académico planteaba asociación entre deficiente alimentación y cocaísmo, atribuidos a la cocaína. Años después, estudios epidemiológicos apoyaron este paradigma. Desde los 70s, publicaciones antropológicas cuestionaron esta asociación y defendieron el uso social de la coca. En los años 80 se demostraron efectos farmacológicos de la coca y cocaína en la reducción del consumo de alimentos en animales de experimentación, que apoyaron la antigua hipótesis de Gutiérrez-Noriega.
Substantiation of Parameters and Operating Modes for the Bunch Planting Device of the Pneumatic Seeder
Authors: Kravchenko Ivan A. , Krasnov Ivan N. , Potseluev Aleksandr A. , Sidorov Vladimir D. 
Published: December 2019

Abstract
The purpose of this work is to develop a dosing system that provides high-quality bunch planting of watermelon seeds with a given seeding rate and their uniform distribution over the plant nutrition area. It is important to know how many seeds it is needed in the bunch in order to provide the required number of plants in a certain plant nutrition area. The method to achieve this goal is to determine the optimal operating modes for the seeding device, in which the dosing system would supply the seed to the bunch without gaps, searching for dependencies that can determine the required number of the sown seeds in the bunch, taking into account their germination and the number of plants specified by agrotechnical conditions in every bunch. Based on the obtained dependencies, determining the probability of bunches with various numbers of plants, while sowing four seeds in the seedbed with maximum field germination, the design of experimental seed discs is proposed, allowing bunch planting and germination due to easy destruction of the soil crust. At the same time, optimal use of the nutritional area for plants, and, consequently, an increase in the yield of the sown crops is ensured. Experimental seed discs with a group arrangement of suction holes (four cells each) will provide bunch planting of watermelon seeds in accordance with agrotechnical requirements.
CRYO PRESERVATION OF HUMAN DENDRITIC CELLS FOR CLINICAL USE
Authors: Chkadua G. Z. , Borunova A. A. , Shoua I. B. , Dolgopolov I. S. , Pimenov R. I. , Mikhailova I. N. , Zabotina T. N. , Baryshnikova M. A. 
Published: December 2019

Introduction. The increasing clinical use of cellular technologies suggests the possibility of long-term storage of the cellular product while maintaining its viability and basic properties. The procedures of cell’s cryopreservation used in laboratory as well in clinical practice differ a lot. Each method includes two tasks to solve: what is the optimal freezing medium to use and what cryopreservation procedure to prefer. In this paper, we present the method utilized in our center for bone marrow cell cryopreservation. The freezing was carried out in nitrogen vapor after adding the medium containing 95 % dextran [average mw 50 000–70 000] and 5 % dimethylsulfoxid.Purpose. To show that the proposed method of cryopreservation of dendritic cells is highly effective, simple, reproducible and most convenient for clinical use.Materials and methods. Viability, expression of surface antigens and stimulating activity towards allogeneic T lymphocytes of cryopreserved mature dendritic cells cultured from peripheral blood monocytes were evaluated.Results. The first cryopreservation resulted in the death of a small amount of cells. The second freezing procedure increased the proportion of dead cells. Meanwhile, the difference in the expression of the surface antigens in fresh, cryopreserved and re-cryopreserved dendritic cells was not statistically significant. The level of stimulating activity of fresh and cryopreserved dendritic cells did not significantly differ. Conversely the proliferation of allogeneic T lymphocytes was decreased after stimulation with re-cryopreserved dendritic cells.Conclusion. The presented method of cryopreservation allows to preserve the viability and basic functions of dendritic cells. After thawing dendritic vaccine could be administered to patients after being diluted in an isotonic saline without washing, which makes this method the most convenient for clinical use.
Self Image Orangtua dalam Memilih Lembaga Pendidikan Anak Usia Dini (Studi kasus pada PAUD Ar Ridho Kota Malang)
Authors: Izzani Cevyana Nafa , Dayati Umi , Ihsan M. Ishom 
Published: December 2019

Abstract: This study aims to determine the parent's Self Image in the selection of audits. The research design used by the researcher is a case study design. This research was conducted in Tarbiyatul Athfal Ar Ridlo, Malang. The key informants selected by the researcher were 4 people, amely the principal and three student guardian. Data collection technique in this study was interviews, document study and observation. Data were analyzed qualitatively which includes the process of data reduction, data display, and verification. Data validity test is done by triangulation techniques and observation extension. The analysis shows that in the view of TA Ar Ridlo's parents are expensive schools that have good quality that raises socialite, fashionable and classy Self Image of parents Abstrak: Penelitian ini bertujuan untuk mengetahui Self Image orangtua dalam pemilihan lembaga PAUD. Rancangan penelitian yang digunakan oleh peneliti adalah rancangan penelitian studi kasus. Penelitian ini dilaksanakan di Tarbiyatul Athfal Ar Ridlo Kota Malang. Informan kunci penelitian ini sebanyak 4 orang, yaitu kepala sekolah dan tiga walimurid. Teknik pengumpulan data dalam penelitian ini adalah wawancara, studi dokumen dan observasi. Data dianalisis secara kualitatif yang meliputi proses reduksi data, display data, dan verifikasi. Uji keabsahan data dilakukan dengan teknik triangulasi dan perpanjangan pengamatan. Hasil analisis menunjukkan bahwa menurut pandangan orangtua TA Ar Ridlo merupakan sekolah mahal yang memiliki kualitas baik yang memunculkan Self Image sosialita, fashionable dan berkelas dari orangtua
Eminectomy for the management of unilateral chronic, recurrent temporomandibular joint dislocation: a case report
Authors: Mehta Sandeep , Kumar Andrews Navin , Dua Gaurav , Sambyal Shanender Singh 
Published: December 2019

<p class="abstract">In this case reportunilateral chronic mandibular dislocation was managed by Myrhaug’s procedure (eminectomy). Temporomandibular joint (TMJ) dislocation is a uncommon clinical entity and surgery is a more definitive option when it’s come to the management chronic and recurrent TMJ dislocation. Eminectomy is shown to be efficient in preventing TMJ dislocations without affecting the maximum mouth opening, articulation and masticatory efficiency.</p><p class="abstract"> </p>
sodA and gap Genes as Markers for The Identification of Staphylococcus capitis
Authors: Firdaus Rininta , Jartun Hege Hartz , Khider Miriam 
Published: December 2019

BACKGROUND: Rapid and accurate identification of Staphylococcus capitis is required to provide a better prognosis for endocarditis patients and tackle the emergence of multidrug resistant strains of the bacteria in hospitals. The current study was aimed to develop polymerase chain reaction (PCR) assay for specific identification of S. capitis using sodA and gap genes as markers.METHODS: Five sequences of sodA and sixteen sequences of gap registered in GeneBank were analysed using bioinformatic tools. PCR primers were designed based on the conserved and specific regions of sodA and gap. Four clinical isolates of S. capitis (named no. 56-59) and six reference strains of coagulase-negative staphylococci (CoNS) species including S. epidermidis ATCC 35984, S. epidermidis 48951I/09, S. lugdunensis 44987/09, S. sciuri 109645I/08, S. warneri 135612/09, S. hominis 114202/08 were used to validate the conventional PCR system.RESULTS: The current PCR system only amplified the DNA template of S. capitis. Current primers specifically targeted S. capitis as the agarose images only showed bands from S. capitis samples.CONCLUSION: The sodA and gap genes might serve as effective markers for identification of S. capitis using conventional PCR. The PCR assay in the current study was able to identify five clinical isolates of S. capitis accurately without mispriming, misamplification and misidentification. The PCR system was also able to discriminate other CoNS including S. epidermidis, S. lugdunensis, S. sciuri, S. warneri and S. hominis.KEYWORDS: Staphylococcus, S. capitis, sodA, gap, PCR