bluuebunny/crossref_metadata_2025_split huggingface dataset:
Velocity‐Based Earthquake Detection Using Downhole Distributed Acoustic Sensing—Examples from the San Andreas Fault Observatory at Depth
Authors: Lellouch Ariel , Yuan Siyuan , Ellsworth William L. , Biondi Biondo 
Published: November 2019

AbstractConventional seismographic networks sparsely sample the wavefields excited by earthquakes. Thus, standard event detection is conducted by analyzing separate stations and merging their results. Emerging distributed acoustic sensing recording technologies allow for unbiased spatial sampling of the wavefield and, as a result, array‐based processing of the recorded signals. Using a cemented fiber in the San Andreas Fault Observatory at Depth main hole, 800 virtual receivers are sampled at a 1 m interval from the surface to 800 m depth. Recorded earthquakes are approximated as plane waves reaching the bottom of the array first. Following this assumption, the relative travel times of the recorded event depend on the local velocity at the array location and the angle of incidence at which the planar wavefront reaches it. Given the seismic velocity, a newly proposed detection algorithm amounts to a single‐parameter scan of the incidence angle and measurement of data coherency along the different possible travel‐time curves. Using the entire recording array, a much higher effective signal‐to‐noise ratio can be obtained when compared to individual channel processing. About 20 days of recorded seismic activity from the San Andreas Fault is analyzed. Using a downhole single array, the majority of cataloged events in the area are detected. In addition, a previously unknown event is unveiled. We estimate its magnitude at roughly −0.5.
Creating a Culture of Wellness: A Call to Action for Higher Education, Igniting Change in Academic Institutions
Authors: Amaya Megan , Donegan Teresa , Conner Debbie , Edwards Julie , Gipson Christy 
Published: November 2019

Background: Due to the continued rise of chronic conditions and unhealthy lifestyle choices, more innovative and evidence-based practices are needed for students, faculty and staff to improve population health outcomes and enhance overall well-being. Aim: The purpose of this paper is to inform academic health promotion professionals of key strategies to consider in order to create cultures of wellness on their college campuses. Methods: A review of the existing literature was conducted.Results: The most current evidence-based practices to create a culture of wellness are discussed. Conclusions:Institutions of higher education have an opportunity to create campus cultures that foster health and well-being. The time is now for enacting change to create, improve, or sustain cultures of wellness within campus communities.
The role of budesonide and mometasone furoate on the nasal and sinus symptoms in allergic rhinosinuitis: a randomized study
Authors: Govindaraj Sriram , Arivazhagan Ganeshbala , Subramani Jayendiran , Iype Jinu Vadakkanethu , Chakkravarthy Ilango 
Published: November 2019

<p class="abstract"><strong>Background:</strong> Allergic rhinosinuitis is one of the common clinical problems that otorhinolaryngologist faces daily. Sinusitis symptoms like headache, facial pain and eyelid oedema are frequent in patients with allergic rhinitis, which in turn will affect the cognitive function, productivity and quality of life which impair the efficiency of the individual work performance. It may result in a prescription for antibiotics but the role of antibiotics is debated. Anti-inflammatory drugs such as intranasal steroids play a major role in reducing the symptoms of allergic rhinitis. We plan to compare the efficacy of budesonide nasal spray with mometasone furoate nasal spray in reducing the nasal and sinus symptoms of allergic rhinosinusitis.</p><p class="abstract"><strong>Methods:</strong> 146 patients of allergic rhinitis with sinusitis symptoms were randomly divided into 2 groups as Group A (n=70) received 256 μg budesonide nasal spray of once daily and Group B (n=76) received 200 μg of mometasone furoate nasal spray daily. The patients were assessed by sino-nasal outcome test (SNOT) score and total nasal symptom score (TNSS) at 2, 6 and 12 weeks interval. </p><p class="abstract"><strong>Results:</strong> There is significant reduction in both the groups, in respect to the SNOT and TNSS scores. We also observed significant improvement in the SNOT score in the budesonide group when compared with the mometasone furoate group by 6weeks which continued till the 12 weeks (p=0.001).</p><p class="abstract"><strong>Conclusions:</strong> Budesonide nasal spray is more effective than mometasone furoate spray in managing both sinus and nasal symptoms in allergic rhinitis.</p>
So much for Bardolatry! (Drunken) Romeo and Juliet in Shit-faced Shakespeare
Authors: Mills Dan 
Published: November 2019

A review of the Atlanta production of Romeo and Juliet by the Shit-faced Shakespeare company. Argues that the performance "highlighted the populist nature of American Shakespearean appropriation and commodification and the intersection of highbrow and lowbrow culture in American society" and "explores these aspects of Shakespearean appropriation through engagement with the writings of Antonin Artaud, Guy Debord, and Lawrence Levine on the theatre of cruelty, the society of the spectacle, and highbrow and lowbrow culture, respectively."
In newborn piglets does drying versus no intervention reduce the risk of mortality pre-weaning?
Authors: Blackie Nicola 
Published: November 2019

PICO question
In newborn piglets, does drying piglets, compared to no intervention, reduce the level of mortality pre-weaning (up to 28 days)?
Clinical bottom line
Data specifically evaluating drying piglets are limited. Many papers had multiple factors evaluated or were assessments of management in general. There is evidence that drying piglets can reduced mortality and improve thermoregulation of piglets. The cost of such interventions has not been appraised and should be considered on a case-by-case basis. Therefore, currently when advising farmers it could be suggested that the drying of piglets may form part of a number of recommendations given to reduce piglet mortality pre-weaning.
Mentha spicata L., Origanum onites L., Melissa officinalis L. ve Lavandula angustifolia Mill. Bitkilerinde Uçucu Yağ Oranı Üzerine Ontogenetik ve Diurnal Varyabilitenin Etkileri
Authors: ÖZYAZICI Gülen , KEVSEROĞLU Kudret 
Published: November 2019

Bu çalışmada, Labiatae familyasına ait bazı bitkiler (Mentha spicata L., Origanum onites L., Melissa officinalis L. ve Lavandula angustifolia Mill.)’de ontogenetik ve diurnal varyabilitenin uçucu yağ oranı üzerine etkisinin araştırılması amaçlanmıştır. Araştırma, Türkiye’nin Orta Karadeniz Bölgesi’nde yer alan Bafra Ovası koşullarında iki yıl süre ile yürütülmüştür. Çalışmada, üç farklı hasat dönemi (Çiçeklenme öncesi, % 50 çiçeklenme ve % 100 çiçeklenme) ve üç farklı hasat saati [sabah (07.00), öğle (13.30) ve akşam (19.00)] araştırma konusu olarak ele alınmıştır. Araştırma sonucuna göre uçucu yağ oranı değerleri, M. spicata, O. onites, L. angustifolia ve M. officinalis bitkilerinde sırasıyla % 0.83-1.75, % 1.50-2.67, % 0.25-1.33 ve % 0.13-0.50 arasında değişiklik göstermiş olup; M. spicata ve M. officinalis’de % 50, diğer bitkilerde ise tam çiçeklenme devrelerinde en yüksek değer ölçülmüştür. Hasat devreleri uçucu yağ oranını; M. spicata, ve L. angustifolia’da istatiksel olarak anlamlı derecede (p&lt;0.01) etkilerken, O. onites ve M. officinalis türlerindeki etkileri istatistiksel açıdan önemsiz bulunmuştur. Hasat saatlerinin uçucu yağ oranı üzerine etkisi ise tüm bitkilerde önemli ve/veya çok önemli olmuştur. Araştırma sonucuna göre, ontogenetik varyabilite bakımından M. spicata ve M. officinalis bitkilerinin % 50 çiçeklenme döneminde, L. angustifolia ve O. onites bitkilerinin ise % 100 çiçeklenme döneminde hasat edilmesinin; diurnal varyabilite bakımından ise hasatların, M. spicata’da öğle, O. onites ve M. officinalis’te sabah, L. angustifolia’da ise akşam saatlerinde yapılmasının uygun olduğu önerilmiştir.
On-farm Verification of Potassium Fertilization for Major Cereal Crops under Balanced Fertilizers in North Shew Zone of Amhara Region, Ethiopia
Authors: Kassie Kenzemed , Shewangizaw Beza , Lema Getachew , Getaneh Lisanu , Taye Genet , Tigabie Abiro 
Published: November 2019

Abstract
The present study was conducted to investigate the response of major cereal crops to application of potassium with balanced fertilizers as well as to validate newly released soil fertility map of Amhara Region. A field experiment was carried out with different districts of North Shewa of Amhara region: Kewet (Sorghum), Basona warana (Food Barley) Moretena jiru and Mojana wedera (Bread wheat. A randomized complete block design was used, with three replications. The treatments were consisted of NPS, NPS+K, NPSBZn, and NPSBZn+K. The required amount of nitrogen and phosphorus were adjusted to crop and site specific recommendation. The rate of K was 150 kg ha-1 K2O and applied as a straight fertilizer at planting in the form of potassium chloride (KCl).The highest grain yield of sorghum (4301.9 kg ha-1) was recorded under the treatment of NPSBZn and followed by NPS fertilizer application respectively, while lower grain yields (3017.7 and 3186.9 kg ha-1) were recorded under the treatments of NPSBZn and NPS with potassium fertilizer application. Even though statically insignificance both NPS and NPSBZn, application of NPSBZn had gave 5.3% of sorghum grain yield advantage as compared to sole NPS and N fertilizer application. The highest grain yield of barley (4411 kg ha-1) also was recorded under the treatment of NPS and followed by NPS+K respectively, while lower grain yield (3960.6 kg ha-1) was recorded under the treatments of NPSBZn. Grain yield of bread also showed similar trend as grain yield of food barley at Moretena jiru and Mojana wedera districts. Generally the results of this experiment did not showed agronomical viable options due to utilization of potassium with recommended NP nutrient sources and micronutrients. The soil was deficient in organic matter, total nitrogen, and available phosphorus and adequate in available potassium. Thus it can be concluded that potassium is not a yield limiting nutrient but soil nitrogen and phosphorus management need especial attention.
Changes in bacterial composition during in vitro oil degradation experiments using activated sludge from different sources
Authors: Uyeno Yutaka , Matsumoto Akito 
Published: November 2019

Abstract
We monitored bacterial compositional changes during in vitro food oil degradation experiments, wherein activated sludge (AS) from different sources was employed as seed. Two AS samples were collected from different aeration processes at the same plant and one sample was collected from a different plant; these were used for the degradation of synthetic wastewater containing commercial food oil as the sole carbon source. A 16S rRNA gene-based next generation sequencing technique was applied to study the bacterial community in the seed AS samples and resultant water after in vitro degradation for two days. Out of the total assigned genera of 319, 153 were present in all three AS seed samples, while the remaining 166 genera, observed in one or two AS seed samples, accounted for only 5% of the total operational taxonomic units. We found that different bacterial groups of each AS capable of oil degradation were present in the samples after two days' incubation. This suggests that the oil degradation process differently affected the key microbial groups from different sources. Therefore, monitoring of the AS seed and optimizing the degradation condition may be required to achieve efficient degradation performance.
Ignacio Zarragoitía y Jáuregui y la defensa de la Cuba no azucarera
Authors: Cabrera-Prieto Gerardo 
Published: November 2019

En 1811 el Real Consulado de La Habana solicitó una evaluación del estado de los territorios de la isla. Desde Puerto Príncipe, Ignacio Zarragoitía y Jáuregui, enviaba un informe donde se reflejaban los problemas de la región y de la zona centro oriental en general. Jáuregui solicitaba reformas en que eran administrados y una mayor libertad de comercio, similar a la que ya disfrutaba el occidente de la isla.Nuestra propuesta se centra en el análisis de las ideas económicas de Zarragoitía y Jáuregui, quien en su doble condición de hacendado y funcionario del gobierno colonial -administrador de rentas-, puso al descubierto las principales dificultades por las que atravesaba la región centro oriental y adelantó soluciones desde un ángulo no azucarero, que venían a servir de ejemplo del enfrentamiento entre los dos modelos de desarrollo: azúcar versus ganadería. Dos modelos que Juan Pérez de la Riva sintetizaba en la Cuba A -el occidente de la isla- donde predominaba la plantación esclavista y se concentraba la riqueza de la isla frente a la Cuba B, -la zona oriental- cuya actividad fundamental era la ganadería y se caracterizaba por su grado de atraso.
La inserción del Antropólogo en la dirección de pueblos originarios, municipalidad de Rosario, Santa Fe, Argentina: relaciones de fusión y fisión
Authors: Valdata Marcela 
Published: November 2019

En el presente artículo nos proponemos exponer las políticas de gestión de gobierno relacionadas a Pueblos Originarios, en la ciudad de Rosario, Provincia de Santa Fe, República Argentina. Se abordará las relaciones intra e interétnicas, la conformación de los grupos, sus particularidades y procedencia. Expondremos mecanismos de fisión y fusión como principios estructurantes de las mismas en su punto de contacto con otros grupos y/o con el Estado.
Palabras claves: Pueblos Originarios, Gobierno, Fusión/Fisión.
Classical and New Pharmaceutical Uses of Bacterial Penicillin G Acylase
Authors: Cobos-Puc Luis , Rodríguez-Herrera Raúl , Cano-Cabrera Juan C. , Aguayo-Morales Hilda , Silva-Belmares Sonia Y. , Gallegos Adriana C.F. , Hernández José L.M. 
Published: November 2019

Background:
β-lactam antibiotics are the most used worldwide for the treatment of bacterial
infections. The consumption of these classes of drugs is high, and it is increasing around the world.
To date, the best way to produce them is using penicillin G Acylase (PGA) as a biocatalyst.

Objective:
This manuscript offers an overview of the most recent advances in the current tools to improve
the activity of the PGA and its pharmaceutical application.

Results:
Several microorganisms produce PGA, but some bacterial strains represent the primary source
of this enzyme. The activity of bacterial PGA depends on its adequate expression and carbon or nitrogen
source, as well as a specific pH or temperature depending on the nature of the PGA. Additionally,
the PGA activity can be enhanced by immobilizing it to a solid support to recycle it for a prolonged
time. Likewise, PGAs more stable and with higher activity are obtained from bacterial hosts genetically
modified.

Conclusion:
PGA is used to produce b-lactam antibiotics. However, this enzyme has pharmaceutical
potential to be used to obtain critical molecules for the synthesis of anti-tumor, antiplatelet, antiemetic,
antidepressive, anti-retroviral, antioxidant, and antimutagenic drugs.
MicroRNA-212-3p Attenuates Neuropathic Pain via Targeting Sodium Voltage-gated Channel Alpha Subunit 3 (NaV 1.3)
Authors: Li Yingda , Zhang Xizhe , Fu Zhimei , Zhou Qi 
Published: November 2019

Purpose:
To explore the role and potential mechanism of miR-212-3p in neuropathic
pain regulation.

Methods:
Adult male rats were used to establish chronic constriction injury (CCI) model to mimic
the neuropathic pain. Then, paw withdrawal threshold (PWT) and paw withdrawal thermal latency
(PWL) were determined. The concentrations of interleukin 1 beta (IL-1β), interleukin 6 (IL-6) and
tumor necrosis factor-alpha (TNF-α) were measured with enzyme-linked immune sorbent assay
(ELISA) kit and the expression of miR-212-3p was measured by real time quantitative PCR (RTqPCR).
Besides, miR-212-3p agomir was intrathecally injected into CCI rats and the expression of
key apoptotic proteins was determined by western blot. Furthermore, dual-luciferase reporter assay
was used to determine the binding of miR-212-3p and 3’ untranslated regions (3’UTR) of NaV1.3
and the expression levels of NaV1.3 were measured by western blot and RT-qPCR.

Results:
In the CCI group, the PWT and PWL were significantly decreased and IL-1β, IL-6 and
TNF-α were increased. miR-212-3p was decreased in response to CCI. The intrathecal injection of
miR-212-3p agomir into CCI rats improved the PWT and PWL, decreased the IL-1β, IL-6 and
TNF-α, decreased the expression levels of BCL2 associated X, apoptosis regulator (Bax), cleaved
caspase-3 and increased the expression levels of BCL2 apoptosis regulator (Bcl-2). The results of
dual--luciferase reporter assay showed that miR-212-3p could directly bind with 3’UTR of NaV1.3.
The expression of NaV1.3 was up-regulated in CCI rats who were intrathecally injected with miRctrl,
whereas it decreased in CCI rats intrathecally injected with miR-212-3p agomir.

Conclusion:
The expression of miR-212a-3p attenuates neuropathic pain by targeting NaV1.3.
Papillary Tumor of the Pineal Region with Parinaud Syndrome: A Case Report
Authors: Damgacı Lale , Hayat Büşra , Güreşçi Servet 
Published: November 2019

Background:
Less than 1% of all intracranial tumors are in the pineal region. Papillary
tumor of the pineal region is considered one of four pineal parenchymal tumors according to the
2007 World Health Organisation classification of central nervous system tumors. It is mostly seen
in the middle age and it is rare under the age of 17 in the literature. In this report, we aim to present
a case with papillary tumor of the pineal region with both CT and MRI findings, and discuss the
differential diagnosis.

Case report:
A 17-year-old female patient who underwent a treatment of ventriculoperitoneal shunt
due to hydrocephalus 18 months ago applied to the neurosurgery clinic with nausea, vomiting, sensorineural
hearing loss and Parinaud syndrome continuing through 1 month. Computed tomography
(CT) and magnetic resonance imaging (MRI) have been applied. A 58x31x38 mm mass with cystic
and mild hyperdense soft tissue components was observed in the localization of pineal gland and
posterior comissure on non-enhanced CT. MRI examination revealed that the mass filled the pineal
region, contained solid and large cystic components, and hyperintense on T1-weighted images.
After intravenous contrast media injection, the mass enhanced more peripherally. DW-MRI showed
that there is a diffusion restriction in some parts of the soft tissue components. The mass was totally
resected, and pathology report revealed that it is a papillary tumor of the pineal region.

Conclusion:
When a T1-weighted hyperintense and CT hyperdense mass with cystic and solid
components is seen in the pineal region, even if it is rare, papillary tumor should also be considered
in the differential diagnosis after exclusion of other hyperintense lesions in T1-weighted imaging.
Effects of Probiotics in the Management of Infected Chronic Wounds: From Cell Culture to Human Studies
Authors: Brognara Lorenzo , Salmaso Luca , Mazzotti Antonio , Di Martino Alberto , Faldini Cesare , Cauli Omar 
Published: November 2019

Background:
Chronic wounds are commonly associated with polymicrobial biofilm
infections. In the last years, the extensive use of antibiotics has generated several antibiotic-resistant
variants. To overcome this issue, alternative natural treatments have been proposed, including the
use of microorganisms like probiotics. The aim of this manuscript was to review current literature
concerning the application of probiotics for the treatment of infected chronic wounds.

Methods:
Relevant articles were searched in the Medline database using PubMed and Scholar,
using the keywords “probiotics” and “wound” and “injuries”, “probiotics” and “wound” and
“ulcer”, “biofilm” and “probiotics” and “wound”, “biofilm” and “ulcer” and “probiotics”, “biofilm”
and “ulcer” and “probiotics”, “probiotics” and “wound”.

Results:
The research initially included 253 articles. After removal of duplicate studies, and
selection according to specific inclusion and exclusion criteria, 19 research articles were included
and reviewed, accounting for 12 in vitro, 8 in vivo studies and 2 human studies (three articles
dealing with animal experiments included also in vitro testing). Most of the published studies about
the effects of probiotics for the treatment of infected chronic wounds reported a partial inhibition of
microbial growth, biofilm formation and quorum sensing.

Discussion:
The application of probiotics represents an intriguing option in the treatment of
infected chronic wounds with multidrug-resistant bacteria; however, current results are difficult to
compare due to the heterogeneity in methodology, laboratory techniques, and applied clinical
protocols. Lactobacillus plantarum currently represents the most studied strain, showing a positive
application in burns compared to guideline treatments, and an additional mean in chronic wound
infections.

Conclusions:
Although preliminary evidence supports the use of specific strains of probiotics in
certain clinical settings such as infected chronic wounds, large, long-term clinical trials are still
lacking, and further research is needed.
LC-MS/MS Profiling of 37 Fingerprint Phytochemicals in Oenanthe fistulosa L. and its Biological Activities
Authors: Souilah Nabila , Bendif Hamdi , Ullah Zain , Miara Mohamed Djamel , Laib Messaoud , Öztürk Mehmet , Akkal Salah , Medjroubi Kamel , Mustafa Ahmed M. 
Published: November 2019

Background:
Oenanthe fistulosa L. (Apiaceae) is often associated with damp soils. Its
underground parts and the young leaves are mainly cooked with other vegetables.

Objective:
The aim of the current work was to investigate the chemical profile of dichloromethane
(DCM), Ethyl Acetate (EA) and n-butanol (BuOH) fractions of O. fistulosa through analysis of 37
phytochemicals by LC-MS/MS and to evaluate their biological activities such as antioxidant, anticholinesterase
and antityrosinase for the first time.

Methods:
Analysis of 37 phytochemicals was performed by Liquid Chromatography-Mass Spectrometry
(LC-MS/MS). Antioxidant activity was evaluated using five in vitro assays, while anticholinesterase
and anti-tyrosinase activities were performed using Ellman and Dopachrome methods,
respectively.

Results:
The number of phenolic compounds detected in DCM, EA and BuOH fractions was found
to be 9, 15, and 12; respectively. More specifically, 9 phenolic acids were detected and among them,
chlorogenic, tr-ferulic and p-coumaric acids were the most abundant. While 8 flavonoids were detected
and apigetrin, rutin, and quercitrin were the most abundant. In addition, 3 non-phenolic organic
acids (quinic, malic and fumaric acids) were detected in large quantities. Furthermore, the tested
plant fractions demonstrated a noteworthy and strong antioxidant action. The plant displayed very
strong action against Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes; and
BuOH fraction was the most potent one. Finally, BuOH and DCM fractions showed good tyrosinase
inhibitory activity.

Conclusion:
According to the obtained results, O. fistulosa might be a promising candidate for the
alleviation of oxidative stress, neurodegenerative (such as Alzheimer’s disease) and hyperpigmentation
disorders.