bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of FDG-PET and FMISO-PET as a treatment strategy for patients undergoing early-stage NSCLC stereotactic radiotherapy
Authors: Watanabe Shiro , Inoue Tetsuya , Okamoto Shozo , Magota Keiichi , Takayanagi Ayumi , Sakakibara-Konishi Jun , Katoh Norio , Hirata Kenji , Manabe Osamu , Toyonaga Takuya , Kuge Yuji , Shirato Hiroki , Tamaki Nagara , Shiga Tohru 
Published: December 2019

Abstract
Background
We investigated the prognostic predictive value of the combination of fluorodeoxyglucose (FDG)- and fluoromisonidazole (FMISO)-PET in patients with non-small cell lung carcinoma (NSCLC) treated with stereotactic body radiation therapy (SBRT).

Patients and methods
We prospectively examined patients with pathologically proven NSCLC; all underwent FDG and FMISO PET/CT scans before SBRT. PET images were acquired using a whole-body time-of-flight PET-CT scanner with respiratory gating. We classified them into recurrent and non-recurrent groups based on their clinical follow-ups and compared the groups' tumor diameters and PET parameters (i.e., maximum of the standardized uptake value (SUVmax), metabolic tumor volume, tumor-to-muscle ratio, and tumor-to-blood ratio). We performed univariate analysis to evaluate the impact of the PET variables on the patients' progression-free survival (PFS). We divided the patients by thresholds of FDG SUVmax and FMISO SUVmax obtained from receiver operating characteristic analysis for assessment of recurrence rate and PFS.

Results
Thirty-two NSCLC patients (19 male and 13 females; median age, 83 years) were enrolled. All received SBRT. At the study endpoint, 23 patients (71.9%) were non-recurrent and nine patients (28.1%) had recurrent disease. Significant between-group differences were observed in tumor diameter and all the PET parameters, demonstrating that those were significant predictors of the recurrence in all patients. In the 22 patients with tumors > 2 cm, tumor diameter and FDG SUVmax were not significant predictors. Thirty-two patients were divided into three patterns from the thresholds of FDG SUVmax (6.81) and FMISO SUVmax (1.89); A, low FDG and low FMISO (n = 14); B, high FDG and low FMISO (n = 8); C, high FDG and high FMISO (n = 10). No pattern A patient experienced tumor recurrence, whereas two pattern B patients (25%) and seven pattern C patients (70%) exhibited recurrence. A Kaplan-Meier analysis of all patients revealed a significant difference in PFS between patterns A and B (p = 0.013) and between patterns A and C (p < 0.001). In the tumors > 2 cm patients, significant differences in PFS were demonstrated between pattern A and C patients (p = 0.002).

Conclusion
The combination of FDG- and FMISO-PET can identify patients with a baseline risk of recurrence and indicate whether additional therapy might be performed to improve survival.
Transient expression analysis of synthetic promoters containing F and D cis-acting elements in response to Ascochyta rabiei and two plant defense hormones
Authors: Shokouhifar Farhad , Bahrabadi Marjan , Bagheri Abdolreza , Mamarabadi Mojtaba 
Published: December 2019

AbstractIntroduction of a foreign gene coding for a pathogen resistant protein into the target plant and constitutive expression of Resistance (R) proteins may confer high level of resistance. However, genetic engineering could lead to reprogramming of molecular mechanisms that manage physiological behavior, which in turn could lead to undesired results. Therefore, using a pathogen-inducible synthetic promoter approach, response to pathogens could be more specific. Ascochyta rabiei is a destructive fungal pathogen in chickpea production. In this study, we analyzed the expression pattern of three synthetic promoters in response to pathogen and two defense hormones. We have tested three synthetic pathogen-inducible promoters designated as (1) synthetic promoter-D box-D box (SP-DD), (2) synthetic promoter-F element-F element (SP-FF) and (3) synthetic promoter-F element-F element-D box-D box (SP-FFDD) via Agrobacterium transient expression assay. The cis-acting element designated as ‘D’ is a 31 base pair sequence from the promoter of parsley pathogenesis-related gene 2 (PR2 gene) and the cis-acting element designated as ‘F’ is a 39 base pairs sequence from the promoter of Arabidopsis AtCMPG1 gene. We used mycelial extracts from two pathotypes of A. rabiei as elicitor to define the responsiveness of the promoters against pathogen. Plant phytohormones including salicylic acid and methyl jasmonate were also used to study the promoter sensitivity in plant signaling pathways. Our results showed that the SP-FF promoter was highly inducible to A. rabiei and methyl jasmonate as well, while the SP-DD promoter was more sensitive to salicylic acid. The SP-FFDD promoter was equally responsive to both pathotypes of A. rabiei which is probably due to the complex nature of box D cis-acting element.
DOA estimation of spectrally overlapped LFM signals based on STFT and Hough transform
Authors: Zhang Xiaofa , Zhang Weike , Yuan Ye , Cui Kaibo , Xie Tao , Yuan Naichang 
Published: December 2019

AbstractTraditional subspace methods which are based on the spatial time-frequency distribution (STFD) matrix have been investigated for direction-of-arrival (DOA) estimation of linear frequency modulation (LFM) signals. However, the DOA estimation performance may degrade substantially when multiple LFM signals are spectrally overlapped in time-frequency (TF) domain. In order to solve this problem, this paper proposes single-source TF points selection algorithm based on Hough transform and short-time Fourier transform (STFT). Firstly, the signal intersections in TF domain can be solved based on the Hough transform, and multiple-source TF points around the intersections are removed, so that the single-source TF points set is reserved. Then, based on the Euclidean distance operator, the single-source TF points set belonging to each signal can be obtained according to the property that TF points of the same signal have same eigenvector. Finally, the averaged STFD matrix is constructed for each signal, and DOA estimation is achieved based on multiple signal classification (MUSIC) algorithm. In this way, the proposed algorithm exhibit remarkable superiority in estimation accuracy and angular resolution over the state-of-the-art schemes and can achieve DOA estimation in the underdetermined cases. In addition, the proposed algorithm can still perform DOA estimation when multiple LFM signals intersect at one point. Numerical simulations demonstrate the validity of the proposed method.
Some invariant solutions and conservation laws of a type of long-water wave system
Authors: Zhang Xiangzhi , Zhang Yufeng 
Published: December 2019

AbstractWe propose a generalized long-water wave system that reduces to the standard water wave system. We also obtain the Lax pair and symmetries of the generalized shallow-water wave system and single out some their similarity reductions, group-invariant solutions, and series solutions. We further investigate the corresponding self-adjointness and the conservation laws of the generalized system.
Projective synchronization of different uncertain fractional-order multiple chaotic systems with input nonlinearity via adaptive sliding mode control
Authors: Rashidnejad Heydari Zahra , Karimaghaee Paknosh 
Published: December 2019

AbstractThis paper introduces the projective synchronization of different fractional-order multiple chaotic systems with uncertainties, disturbances, unknown parameters, and input nonlinearities. A fractional adaptive sliding surface is suggested to guarantee that more slave systems synchronize with one master system. First, an adaptive sliding mode controller is proposed for the synchronization of fractional-order multiple chaotic systems with unknown parameters and disturbances. Then, the synchronization of fractional-order multiple chaotic systems in the presence of uncertainties and input nonlinearity is obtained. The developed method can be used for many of fractional-order multiple chaotic systems. The bounds of the uncertainties and disturbances are unknown. Suitable adaptive rules are established to overcome the unknown parameters. Based on the fractional Lyapunov theorem, the stability of the suggested technique is proved. Finally, the simulation results demonstrate the feasibility and robustness of our suggested scheme.
A combined compact difference scheme for option pricing in the exponential jump-diffusion models
Authors: Akbari Rahman , Mokhtari Reza , Jahandideh Mohammad Taghi 
Published: December 2019

AbstractIn the present paper, starting with the Black–Scholes equations, whose solutions are the values of European options, we describe the exponential jump-diffusion model of Levy process type. Here, a jump-diffusion model for a single-asset market is considered. Under this assumption the value of a European contingency claim satisfies a general “partial integro-differential equation” (PIDE). With a combined compact difference (CCD) scheme for the spatial discretization, a high-order method is proposed for solving exponential jump-diffusion models. The method is sixth-order accurate in space and second-order accurate in time. A known analytical solution to the model is used to evaluate the performance of the numerical scheme.
Using the Consolidated Framework for Implementation Research to examine implementation determinants of specialty mental health probation
Authors: Van Deinse Tonya B. , Bunger Alicia , Burgin Stacey , Wilson Amy Blank , Cuddeback Gary S. 
Published: December 2019

Abstract

Background
Specialty mental health probation (SMHP) is designed to improve outcomes for the large number of people with serious mental illnesses who are on probation and/or parole. The evidence for specialty mental health probation is promising; however, little is known about the implementation challenges and facilitators associated with SMHP. To address this gap, we used the consolidated framework for implementation research (CFIR) to analyze 26 interviews with stakeholders representing multiple agencies involved in the implementation of SMHP.

Results
Results indicate a number of challenges and facilitators related to the inner setting, outer setting, implementation process, and characteristics of individuals.

Conclusions
Findings suggest that complex and cross-sectoral interventions are context-dependent and introduce a number of challenges and facilitators related to multiple CFIR domains. Consequently, agency administrators implementing these types of interventions should consider small pilot studies and develop implementation strategies tailored to the local implementation context.
Esmolol for cardioprotection during resuscitation with adrenaline in an ischaemic porcine cardiac arrest model
Authors: Karlsen Hilde , Bergan Harald Arne , Halvorsen Per Steinar , Sunde Kjetil , Qvigstad Eirik , Andersen Geir Øystein , Bugge Jan Frederik , Olasveengen Theresa Mariero 
Published: December 2019

Abstract
Background
The effectiveness of adrenaline during resuscitation continues to be debated despite being recommended in international guidelines. There is evidence that the β-adrenergic receptor (AR) effects of adrenaline are harmful due to increased myocardial oxygen consumption, post-defibrillation ventricular arrhythmias and increased severity of post-arrest myocardial dysfunction. Esmolol may counteract these unfavourable β-AR effects and thus preserve post-arrest myocardial function. We evaluated whether a single dose of esmolol administered prior to adrenaline preserves post-arrest cardiac output among successfully resuscitated animals in a novel, ischaemic cardiac arrest porcine model.

Methods
Myocardial infarction was induced in 20 anaesthetized pigs by inflating a percutaneous coronary intervention (PCI) balloon in the circumflex artery 15 min prior to induction of ventricular fibrillation. After 10 min of untreated VF, resuscitation with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) was initiated and the animals were randomized to receive an injection of either 1 mg/kg esmolol or 9 mg/ml NaCl, prior to adrenaline. Investigators were blinded to allocation. Successful defibrillation was followed by a 1-h high-flow VA-ECMO before weaning and an additional 1-h stabilization period. The PCI-balloon was deflated 40 min after inflation. Cardiac function pre- and post-arrest (including cardiac output) was assessed by magnetic resonance imaging (MRI) and invasive pressure measurements. Myocardial injury was estimated with MRI, triphenyl tetrazolium chloride (TTC) staining and serum concentrations of cardiac troponin T.

Results
Only seven esmolol and five placebo-treated pigs were successfully resuscitated and available for post-arrest measurements (p = 0.7). MRI revealed severe but similar reductions in post-arrest cardiac function with cardiac output 3.5 (3.3, 3.7) and 3.3 (3.2, 3.9) l/min for esmolol and control (placebo) groups, respectively (p = 0.7). The control group had larger left ventricular end-systolic and end-diastolic ventricular volumes compared to the esmolol group (75 (65, 100) vs. 62 (53, 70) ml, p = 0.03 and 103 (86, 124) vs. 87 (72, 91) ml, p = 0.03 for control and esmolol groups, respectively). There were no other significant differences in MRI characteristics, myocardial infarct size or other haemodynamic measurements between the two groups.

Conclusions
We observed similar post-arrest cardiac output with and without a single dose of esmolol prior to adrenaline administration during low-flow VA-ECMO in an ischaemic cardiac arrest pig model.
On mycohuman performances: fungi in current artistic research
Authors: Rapp Regine 
Published: December 2019

AbstractThis review reflects several artists and their artistic research in the field of hybrid art, bio art, or science art, working with Fungi as both subject matter and medium. The work of Saša Spačal, Tarsh Bates and Theresa Schubert is not representational in the manner of traditional fine art, but works rather through performative, multidisciplinary and research-based strategies to produce artwork through fungal material as such. My research results are based on the series “Nonhuman subjectivities” and “Nonhuman agents” that Christian de Lutz and I conceived and realized at Art Laboratory Berlin (2016–18) in various formats—exhibitions, workshops, lectures and a conference. The work of Saša Spačal and her colleagues involves creating interactive situations of symbiosis between the fungal and the human. An example of this is Myconnect, in which a biofeedback loop is related between the human participant and Oyster mushroom mycelia through a special encounter, which is mediated by non-linguistic forms of awareness and exchange—sonic, electronic and metabolic. Tarsh Bates’ work with Candida albicans and Candida parapsilosis refers to a complex and intimate relation between the human and yeasts that form part of the human microbiome. Bates considers the relationship between humans and yeast as “CandidaHomo Ecologies” and sees both partners as equals. She explores this relationship through her work The Surface dynamics of adhesion, examines it from historical and metabolic levels through an installation that includes the live yeast growing on agar mixed with the artist’s own blood. Theresa Schubert’s installations and site-specific interventions treat living organisms, especially Fungi, as collaborators and co-creators. Her work Growing Geometries—Tattooing Mushrooms follows the morphological development of fungal fruiting bodies through the intervention of a tattoo. Her performative forest walks, especially the Forestal Psyche and also new actions for the “Mind the Fungi” project, engage the public in an intimate and multi sensory encounter with Fungi and their surrounding environment.
Axial torsion of Meckel’s diverticulum causing acute peritonitis in the first trimester of pregnancy: a case report
Authors: Nagata Hiromitsu , Nishizawa Hiroyasu , Mashima Susumu , Shimahara Yasuyuki 
Published: December 2019

Abstract
Background
Meckel’s diverticulum is considered the most prevalent congenital anomaly of the gastrointestinal tract. Approximately 4% of patients are symptomatic with complications such as bleeding, intestinal obstruction, and inflammation, while axial torsion of Meckel’s diverticulum is rare, particularly in pregnancy.

Case presentation
A 31-year-old woman in week 15 of pregnancy complained of epigastric pain, nausea and vomiting. Clinical diagnosis was severe hyperemesis gravidarum. Because the symptoms persisted during hospitalization, CT was performed and revealed dilated small bowel loops with multiple air-fluid levels. In the right mid-abdomen, there was a large part of air containing a cavity connected to the small intestine, which was considered a dilated bowel loop. Emergency laparotomy was performed and axial torsion of a large Meckel’s diverticulum measuring 11 cm was found at a few centimeters proximal to the ileocecal valve. Ileocecal resection including Meckel’s diverticulum was performed. The postoperative course was uneventful. At 40 weeks gestation, she had vaginal delivery of normal baby.

Conclusion
The physiological and anatomical changes in pregnancy can make a straightforward clinical diagnosis difficult. Prompt diagnosis and management were needed in order to avoid significant maternal and fetal risks. The use of imaging examinations, especially CT examination, with proper timing may be helpful to prevent delay in diagnosis and surgical intervention. Here, we report the case of a patient with axial torsion of Meckel’s diverticulum in pregnancy. To our knowledge, axial torsion of Meckel’s diverticulum in the first trimester of pregnancy has not been reported in the English medical literature.
Investigating clinical characteristics and prognostic factors in patients with chronic osteomyelitis of humerus
Authors: Wu Hongri , Yu Shengpeng , Fu Jingshu , Sun Dong , Wang Shulin , Xie Zhao , Wang Yungui 
Published: December 2019

Abstract

Background
Chronic osteomyelitis in the humerus, which has complex neuroanatomy and a good soft tissue envelope, represents a unique clinical challenge. However, there are relatively few related studies in the literature. This article retrospectively reviewed a large case series with the aims of sharing our management experiences and further determining factors associated with the outcomes.

Methods
Twenty-eight consecutive adult patients with a mean age of 36 years were identified by reviewing the osteomyelitis database of our clinic centre. The database was used to prospectively identify all osteomyelitis cases between 2013 and 2017, and all data then was retrospectively analysed.

Results
The mean follow-up period was 35 months (range 24–60). The aetiology was trauma in 43% (12) of the patients and haematogenous in 57% (16) of the patients, and Staphylococcus aureus was a solitary agent in 50% (14) of the patients. Host-type (Cierny’s classification) was IA in 8, IIIB in 11 and IVB in 9 patients. All patients required debridement followed by the placement of a temporary antibiotic-impregnated cement spacer (rod). Seventeen patients received a cement-coated plate for internal fixation after debridement, and 13 patients needed bone grafts when the spacer was staged removed. All patients attained an infection-free bone healing state at the final follow-up. The final average DASH (disabilities of the arm, shoulder and hand) score was 18.14 ± 5.39, while 6 patients (two developed traumatic olecranarthritis, four developed radial nerve injuries) showed the lowest levels of limb function (p = 0.000) and were unemployed. Three patients (type I; significant difference between type I versus type III and type IV patients, p &lt; 0.05) experienced recurrence after debridement and underwent a second revision, which was not related to the bone graft (p = 0.226) or plate fixation (p = 0.050).

Conclusions
Humeral chronic osteomyelitis can be treated with general surgery and anti-infective therapy; medullary (type I) infection presents a challenge, and the antibiotic-coated cement plate provides favourable fixation without increasing recurrence of infections. Clinicians should be aware of potential iatrogenic nerve injuries when treating these patients with complicated cases, and an experienced surgeon may improve the outcome.
Successively expressed cuticular protein genes at the prepupal stage in wing discs of Bombyx mori
Authors: Ali Md Saheb , Mishra Birendra , Swapon Ahsanul Haque , Yamaguchi Masamitsu 
Published: December 2019

AbstractBackgroundWe classified cuticular protein genes expressed at prepupal stage in wing discs ofBombyx moriinto six groups according to their developmental expression and ecdysone responsiveness. Their expression pattern is suggested to be regulated by ecdysone-responsive transcription factors, whose transcripts showed resemblance with those of cuticular protein gene expression.ResultGroup1 and Group2 CP genes showed peak expression at stage W2. Group3 CP genes showed high expression at stage W3E and W3L and were upregulated by 20E addition, showing a peak 12 h after 20E pulse treatment. Group4 CP gene transcripts started expression from stage V5 and peaked at stage W3L. Some genes showed significant increase 4 or 6 h after 20E addition and were induced 6 h and showed a peak 18 h after the 20E pulse treatment. Group5 CP gene transcripts peaked at the same stage W3L. Some Group5 genes showed significant increase 6 h after the 20E addition, while others were not induced by the 20E addition. These different sub-groups showed different expression profiles in the feeding stage. Transcripts of this group genes were induced 12 h and showed a peak 18 h after the 20E pulse treatment. Group6 CP genes peaked at the stage P0, were not induced by the 20E addition, and showed a peak 24 h after the 20E pulse treatment. Group3, 4, 5, and 6 CP genes are suggested to be regulated by BHR4, BR-C, E74A, and βFTZ-F1, respectively. ERTFs showed different responsiveness to 20E concentration. BR-C was most and E74A was least insensitive. The addition of cycloheximide inhibited BR-C, E74A, and βFTZ-F1 expression depending on the length of treatment after ecdysone pulse treatment, which suggests that BHR4 induced BR-C, E74A, and βFTZ-F1.ConclusionExpression patterns of CPs were determined by the ecdysone-responsiveness and the related ERTFs expressed in the prepupal stage inB. moriwing discs.