bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of mHealth interventions on postpartum depression: A systematic review and meta-analysis
Authors: Zhou Chuqing , Hu Hua , Wang Chunyi , Zhu Ziyu , Feng Gengchen , Xue Jingping , Yang Ziyi 
Published: April 2020

Introduction Postpartum depression (PPD) is a common psychiatric condition during the postnatal period that negatively impacts the well-being of both the mother and her infant. This study describes a systematic review and preliminary meta-analysis to assess the efficacy of mobile health (mHealth) interventions, which is defined as the use of portable electronic devices to support public health and medical practice, in addressing depressive symptoms among postpartum women. Methods Databases including PubMed, PsycINFO, the Cochrane Library, Embase and ClinicalTrials.gov were searched for randomized controlled trials (RCTs) assessing the effectiveness of mHealth interventions on PPD from database inception to December 2019. Results The initial search identified 754 studies, of which, 11 studies fulfilled the inclusion criteria. These studies evaluated four types of distinct mHealth interventions and involved 2424 participants across six countries. Pooled results demonstrated that compared to the controls, the Edinburgh Postnatal Depression Scale score decreased in the mHealth intervention group (mean difference: –1.09, 95% confidence interval: –1.39 to –0.79). Discussion Our study suggested that mHealth interventions may be a promising tool to complement routine clinical care in the prevention and treatment of PPD, but the clinical effectiveness of mHealth interventions needs to be better established. While most studies focused on telephone-based interventions, recent researches have also suggested the superiority and effectiveness of short messaging service (SMS) and smartphone applications, but the exact efficacy needs further evaluation. Therefore, more high-quality RCTs on app-based and SMS-based interventions are needed before the large-scale roll-out of these interventions in clinical practice.
Exploring mistakes and errors of professional judgement in social work in China and Italy: The impact of culture, organization and education
Authors: Sicora Alessandro , Lu Wei , Lei Jie 
Published: April 2020

Summary This article reports the results of an exploratory comparative study that investigated errors made by social work practitioners. Two groups of social workers, one in Italy and one in Mainland China, answered questions about the causes and effects of mistakes, professional errors and reactions to errors committed by their colleagues, and the influence of intuition on the decision-making process that generates mistakes and errors of professional judgement. Findings The most salient differences between the Italian and Chinese respondents related to their willingness to talk about their mistakes and their confidence in the training received. A longer social work tradition in Italy helps practitioners in that country to feel stronger and to engage in a reflective learning process rather than defensive actions. As members of a new and not yet fully recognized profession, social workers in Mainland China are more likely to blame external circumstances for negative outcomes. Both groups shared the same positive consideration of intuition and the risk of losing service users’ trust. Applications The purpose of the article is to foster better understanding of errors and mistakes in social work, as well as more open discussion and reflection on social work practice and how to prevent negative outcomes.
Radial club hand treated with soft-tissue distraction and subsequent pin stabilization: mid- to long-term results
Authors: Pfister Georges , Le Hanneur Malo , Bachy Manon , Fitoussi Franck 
Published: April 2020

Radial club hand deformities are commonly treated with arthrolysis to allow centralization of the ulna. In this retrospective cohort study of 31 hands in 28 patients, we aimed to assess the outcomes of correction using progressive distraction and subsequent percutaneous pinning of the wrist with a corrective ulnar osteotomy. Mean follow-up time was 7 years (range 2 to 20). The angulation of the hand–forearm complex was decreased after each step of the procedure. Mean correction of the angulation was 64°, and the residual total forearm–hand angulation was 12° after completion of the surgery. At the time of bony maturity (four patients), all wrists had fused. Fifty-eight reoperations were required in 31 wrists because of pin migration or breakage, and in addition 18 secondary osteotomies of the ulna were performed. From this study we conclude that distraction and pinning provide satisfactory and stable realignment of the wrist to correct the deformity, but this treatment has drawbacks regarding the high number of reoperations and the loss of wrist mobility. Level of evidence: IV
Impact of depressive disorders on primary total shoulder arthroplasties: a matched control analysis of 113,648 Medicare patients
Authors: Swiggett Samuel J , Vakharia Ajit M , Ehiorobo Joseph O , Vakharia Rushabh M , Roche Martin W , Mont Michael A , Choueka Jack 
Published: April 2020

Introduction The purpose of this study was to investigate whether patients with depressive disorders undergoing primary total shoulder arthroplasty have higher rates of (1) in-hospital lengths of stay, (2) readmission rates, (3) medical complications, and (4) implant-related complications. Methods A retrospective query was performed using a national claims database. Study group patients were matched to controls in a 1:5 ratio according to age, sex, and medical comorbidities. The query yielded 113,648 patients who were with (n = 18,953) and without (n = 94,695) depressive disorders. Pearson’s χ 2 analyses were used to compare patient demographics. Logistic regression analyses were used to calculate odds-ratios of complications and readmission rates. Welch’s t-tests were used to test for significance for in-hospital lengths of stay. A p-value less than 0.003 was considered statistically significant. Results Study group patients had significantly longer in-hospital lengths of stay (2.7 days versus 2.3 days; p < 0.0001). Patients who have depressive disorders had higher incidences and odds of readmissions (9.4 versus 6.15%; odds-ratio: 1.6, p < 0.0001), medical complications (2.7 versus 0.9%; odds-ratio: 3.0, p < 0.0001), and implant-related complications (6.1 versus 2.4%; odds-ratio: 2.59, p < 0.0001) compared to controls. Conclusion Depressive disorder patients have longer in-hospital lengths of stay and increased odds of readmissions and complications following primary total shoulder arthroplasty.
Aging-induced IL27Ra signaling impairs hematopoietic stem cells
Authors: He Hanqing , Xu Panglian , Zhang Xiaofei , Liao Min , Dong Qiongye , Cong Tingting , Tang Baixue , Yang Xiuxiu , Ye Maoqing , Chang Yingjun , Liu Weihua , Wang Xiaowo , Ju Zhenyu , Wang Jianwei 
Published: April 2020

Abstract
Hematopoietic stem cell (HSC) aging correlates with an increasing risk of myeloproliferative disease and immunosenescence. In this study, we show that aging-related inflammation promotes HSC aging through tumor necrosis factor-α (TNF-α)→ERK→ETS1→interleukin27Ra (IL27Ra) pathway. TNF-α, a well-known biomarker of inflammation, increases during aging and induces the expression of IL27Ra on HSCs via ERK-ETS1 signaling. Deletion of IL27Ra rescues the functional decline and myeloid bias of HSCs and also reverses the inhibitory effect of TNF-α on HSCs. Aged IL27Ra−/− mice had a reduced proportion of myeloid-biased HSCs and did not display the biased myeloid differentiation that occurs in aged wild-type mice. IL27Ra+ HSCs exhibit impaired reconstitution capacity and myeloid-bias compared with IL27Ra− HSCs and serve as a myeloid-recovery pool upon inflammatory insult. Inflammation-related genes were enriched in IL27Ra+ HSCs and this enrichment increases with aging. Our study demonstrates that age-induced IL27Ra signaling impairs HSCs and raises the possibility that interfering with IL27Ra signaling can counter the physiologically deleterious effect of aging on hematopoietic capacity.
Tissue Factor (TF) Activity in Trauma Patients Is Suppressed on Cell-Derived Microparticles (MP).
Authors: Horstman Lawrence L. , Jy Wenche , Bidot Carlos J. , Jimenez Joaquin J. , Ahn Yeon S. 
Published: April 2020

Abstract
BACKGROUND & AIMS. Traumatic injury is expected to expose or release into circulation large amounts of procoagulant material, including TF from subendothelial tissues, yet thrombosis is rarely an immediate concern. To investigate the basis of this, we measured TF activity and TF antigen (TF:Ag) associated with MP (believed to be a main carrier of circulating TF) in trauma patients.
METHODS. With IRB approval, two tubes of citrated blood were obtained upon admission from each of 18 patients and were processed within 2hr. Four patients were followed up 5–7 days later. MP were isolated from 0.9mL platelet-poor plasma (PPP) by centrifuging at 16,000g for 15min, then resuspending in 0.45mL Tris-saline pH 8.0 with brief (5sec) ultrasonic probe. Then 10uL was added to reaction mix (0.2mL final vol) in 96-well plate on ice containing physiologic amounts of FX, FVII, FVa, prothrombin, phospholipid and chromogenic substrate for thrombin, S-2238, then calcium to start reaction. Plate was then warmed (t=0) on metal block in 37° oven with fan and absorbance (OD) read at intervals from 6 min to 20min at 405nm. Known standards of pure thrombin and TF enabled conversion from OD to units of thrombin per ug TF/min. Flow cytometry was used to measure TF:Ag in PPP by fluorescent mAb.
RESULTS. (i) The apparent TF activity of patient MP was significantly or markedly reduced in 16 of 18 trauma patients, to as little as 10% of controls (mean of the 16 was 45.4%, median 47.7%). This was not seen in any other group of clinical patients. (ii) However, comparing rates of thrombin production by plotting log OD vs. time (giving straight line, R&gt;0.97, as expected since thrombin accumulates in this method) revealed that final rates were often similar to controls. This was explained by prolonged lag phase in patients. Extrapolation back to OD=0.01 showed origin delayed by 2–8min in trauma patients relative to controls. (iii) Neither MP numbers or TF antigen differed significantly or consistently from controls; TF-positive MP in plasma were 529 ±196 vs. 581 ±279 per mL for patients and controls respectively.
CONCLUSIONS. Trauma patients do not exhibit elevated circulating TF activity on MP. The prolonged lag phase might be explained by presence of increased protective TFPI or cryptic state in patients, requiring more time for expression of full activity in assay medium, supported by other experiments showing that anti-TFPI restored normal or above-normal activity in trauma patients.
Treatment of B-CLL Cells with Bortezomib and Rituximab Reduces Cell Viability In Vitro..
Authors: Lewintre Eloisa Jantus , Sarsotti Elena , Terol Maria Jose , Benet Isabel , Martinez-Climent Jose A. , Garcia-Conde Javier 
Published: April 2020

Abstract
Introduction: In B-CLL, somatic mutation of IgVH genes defines a group of patients with favorable prognosis, whereas the absence of IgVH mutations is correlated with a worse outcome. Our previous data suggested that BCL-6 mutations identify a subgroup of patients with high risk of progression despite the presence of mutated IgVH gene, but the clinical significance of this molecular alteration remains uncertain. New approaches are now being tested for the treatment of B-CLL. Proteasome inhibitor, Bortezomib (Btz), and monoclonal antibodies specific for surface antigens, Rituximab (Rtx), represent potential therapeutic strategy.
Objetives: To study the effects of Btz and Rtx on viability of CLL cells in culture, and to correlate the responses to the mutational status of the samples.
Material and Methods: PBMC from 29 B-CLL patients (Binet stage A) were isolated by Ficoll-Hypaque gradient centrifugation. Samples were culture in RPMI supplemented with 20% FCS. Complement rabbit serum was added to the cultures in Rtx treated cells. Cells were exposed to various concentrations of Btz (0.1, 1 and 10 uM), Rtx (10 ug/ml) or both together during 24 hours. Then, cells were stained with Propidium Iodide and subjected to flow cytometry analysis.
Results: Btz and Rtx reduce viability of B-CLL cells in a dose and time dependent manner. The kinetic of both drugs were different, whereas Rtx reaches its maximun effect within 3 hours after treatment, Btz do the same after 48 hours. Combined treatment (Btz + Rtx) increases the effect of each one separately. All differences between treatments with increased doses of Btz + Rtx vs Btz alone were statistically significant. In the group of IgVH mutated patients, there were a significant difference in the response to Btz and Rtx in BCL-6 mutated (mut) and unmutated (unmut) groups (n= 10 and 8 respectively), whereas no significant differences were observed in the number of lymphocytes, lymphocyte doubling time, CD38 expression and cytogenetic alterations.
Effects of Btz and Rtx on IgVH mutated samples: correlation with BCL-6 mutations
BCL-6 Mean viability (%) SD p * * U. Mann Whitney test Control unmut 82.13 8.70 0.42 mut 86.36 6.01 Btz 0.1 uM unmut 49.05 10.39 0.006 mut 64.28 12.16 Btz 1 uM unmut 39.86 7.19 0.040 mut 53.27 13.35 Btz 10 uM unmut 30.21 7.41 0.041 mut 43.99 14.73 Rtx 10 ug/ml unmut 48.31 14.51 0.050 mut 34.62 12.51 Btz 0.1 uM + Rtx unmut 32.96 14.15 0.153 mut 24.50 10.01 Btz 1 uM + Rtx unmut 25.99 10.88 0.315 mut 19.89 7.53 Btz 10 uM + Rtx unmut 19.27 9.04 0.491 mut 16.31 7.52
Conclusion: Our data show that Btz and Rtx have in vitro activity on B-CLL cells, being used alone or in combination. Interesting, in IgVH mutated cells, Btz and Rtx have statistically significant differences in their in vitro activity on B-CLL cells according to their BCL-6 mutational status, but the biological significance of this differential responses remains unclear
Thrombophylic Profile of Fabry Patients in Argentina.
Authors: Aggio Mario C. , Martinez Pablo A. 
Published: April 2020

Abstract
Anderson-Fabry disease (AFD), described independently in the 1890s by William Anderson and Johann Fabry, is the second most frequent lysosomal storage disorder (after Gaucher disease). AFD is a pan-ethnic disorder due to a deficiency of the lysosomal enzime alpha-galactosidase A (alpha-GAL), with an estimated frequency of 1 in 117,000 male births, although recent studies suggest that the incidence may be underestimated, as certain patients with residual alpha-GAL activity (5 to 35% of normal levels) have disease too. Increased incidence of thrombotic events has been demonstrated in AFD. We evaluated the prevalence of prothrombotic risk factors in Argentine patients. Patients/methods: 36 patients (15 hemizygous and 21 heterozygous from 3 families) were studied for: protein C pathway (PCSys), antithrombin (AT), protein C (PC), protein S (PS), activated protein C resistance (APCR), lupus anticoagulant (LA), total plasma homocysteine (tHcy), anticardiolipin antibodies (ACA), and antiphosphatidylserine antibodies (APA). Results: The evaluation of PCSys, APCR, plasmatic levels of PC, PS, AT and APA were normal in all patients. Elevated levels of tHcy were found in 19.4% (n=7). Positive for LA were 38.9% (n=14) and for ACA 8.3% (n=3). Conclusions: 1) Our results confirm data from the literature reporting elevated homocysteinemia in AFD patients. Nutritional deficiencies, renal failure and metabolic disturbances are probable etiologic factors. 2) Thrombophilia was more frequent in hemizygous (13 patients, 86.7%) than in heterozygous (8 patients, 38.1%). Four hemizygous patients showed coexistence of two risk factors. 3) We found an unexpected high incidence of procoagulant autoantibodies. This association has also been reported and might contribute to thrombophilia in AFD: as in Gaucher disease, the accumulation of immunogenic glucocerebrosides might induce chronic immunostimulation.
Appliance of the DNA-Micro Array Technique for the Identification of Patients with Thrombophilic Diathesis. I-Comparison to the Classic PCR Analysis.
Authors: Tsaousidou Maria M.K.T. , Girtovitis Fotis F.I.G. , Boutou Afroditi A.K. , Pithara Elefteria E.P. , Makris Pantelis M.E.P. 
Published: April 2020

Abstract
Introduction: DNA Micro array have the ability to test a large number of samples for a large number of mutations on the same time, something practically impossible with the traditional hybridization methods. The goal of this study is to compare the ability of DNA micro array application to recognize genetic predisposition to thrombosis, with the one of RLF-PCR.
Material: DNA samples from 37 subjects (24 male with mean age 41.9 and 13 female with mean age 38.8) were studied both with micro arrays and PCR analysis. All of these subjects had a history of either recurrent thrombosis or thrombosis at unusual sites (e.g. retina’s central vein thrombosis).
Method: The thrombo-check microarray contains the following mutations and polymorphisms: Factor V Leiden (FV G1691A), FII G20210A (prothrombin mutation), FV Cambridge (FV G1091C), MTHFR C677T, MTHFR A1298C, CBS 844ins68, Plasminogen Activator Inhibitor (PAI 1 4G/5G). The thrombo-check microarray can distinguish between the normal sequence, as well as heterozygosity and homozygosity for the mutated sequence. To ensure the result is correct specific probes are included on the microarray to control for the RLF-PCR reaction, the hybridization reaction and the silver staining procedure. In addition, the correct functioning of the entire reaction can be checked using an external control DNA.
Results: As long as FVL and FII are concerned, in 35 out of 37 patients (pts) both methods gave similar results. However, the results of DNA analysis were different for the other two patients. The first one was found to be, using the micro array DNA method, a double heterozygous carrier of both FVL and FII mutations, while RLF-PCR did not relieve any such genetic defects. The other patient was found to be, using the RLF-PCR a homozygous carrier for the prothrombin mutation, while micro array also revealed heterozygous mutation of FV Leiden. Moreover, the micro array method detected totally 1 patient with FVC, 4 pts homozygous for MTHFR1, 6 pts homozygous for PAI and 4 pts homozygous for MTHFR2 mutation. Further more, micro array detected the co-existence of FVL and homozygocity in a) FII mutation (2 pts), b) PAI mutation (1patient) and c) MTHFR2 (2pts). Finally, 1 patient with FII was found to be also homozygous for MTHFR1 mutation.
Incorporation of a Comprehensive Pediatric Thrombosis Program into the Multidisciplinary Care Team for Children with Congenital Heart Disease: A Prospective Cohort Study.
Authors: Massicotte Mary Patricia , Rebeyka Ivan M. , Bauman Mary , Mitchell Lesley G. , Conradi Alf 
Published: April 2020

Abstract
BACKGROUND: Over the last 10 years, children with congenital heart disease (CHD) have been experiencing increased survival due to diagnostic and surgical techniques. However, associated with this is a requirement for prolonged central venous access which has serious associated sequelae, of which thrombosis is one of the most important. In a busy comprehensive cardiovascular program, the diagnosis, treatment and management of children with or at risk for thrombosis is extremely demanding and constantly changing based on current evidence based recommendations. The Stollery Children’s Hospital, a member of the Western Canadian Children’s Heart Network (WCCHN), is the cardiovascular surgical centre for children with CHD from British Columbia, Manitoba, Alberta, and Saskatchewan An expert Pediatric Thrombosis Team has been incorporated into the multi disciplinary management of children with CHD. This team is dedicated entirely to the diagnosis, management and long term followup of children requiring anticoagulation.
MATERIALS/METHODS: A standard approach to the diagnosis, management and long term followup of children with CHD with or at risk for thrombosis was initiated. The Pendragon data base was custom designed to prospectively collect the following data on all children: demographics, treatment and long term outcome.
RESULTS: Since the inception of the Thrombosis service (Oct 2003) there have been 325 children who required cardiac surgery with 40% (n=129) of these children requiring Thrombosis consultation. The 4 most common causes for Thrombosis referral have been primary prophylaxis post CHD surgery including mechanical valves, Blalock Taussig shunts, and Fontan procedures, 51% (n=66), suspected CVL related thrombosis 26% (n=33), arterial catheter related thrombosis (catheterization or monitoring) 16% (n=19), and extracorporeal membranous oxygenation 9% (n=11). By Oct 2004, it is anticipated that 300 children will have been consulted on.
CONCLUSIONS: The 1st year results of the data collected on this prospective cohort will be presented including demographics, reason for anticoagulation, diagnosis, and long term outcome.
Low Molecular Weight Heparin during Surgery in Parients on Long Term Oral Anticoagulant Treatment (OAT): A Prospective Observational Study.
Authors: Baudo Francesco , Mostarda Gianni , Ghirarduzzi Angelo , Molinatti Maurizio , Pengo Vittorio , Poli Daniela , Tosetto Alberto , Tiraferri Eros , Morra Enrica 
Published: April 2020

Abstract
The perioperative management of patients on long term OAT is an open issue. The problem is the prevention of both the thromboembolic (TE) and the hemorrhagic complications. The therapeutic options are: 1) discontinuation of OAT with an INR target &lt;2.0 at the scheduled time and its resumption after surgery, 2) substitution of OAT with low molecular weight heparin (LMWH) in the perioperative period. We report on 477 consecutive patients who underwent elective surgery in 7 FCSA centers (November 2001 to August 2003). Major and minor surgery and other minor procedures were carried out in 68, 206 and 203 patients respectively; median age 72 years (25–97); 279 males, 198 females. The aim of the study was to evaluate the complications occurring during and within 2 months after surgery with the different modalities of prophylaxis. Indications for OAT./bold]Low and intermediate TE risk patients:secondary prophylaxis of venous thrombosis (VT) 75; non valvular atrial fibrillation (AF) 225; aortic mechanical or biological valves 58, dilatative myocardiopathy 8, valvulopathy 10; myocardial infarction 3; coronary artery by-pass graft 4; stroke 4.High TE risk patients: mitral mechanical valve, mechanical valves + AF or previous TE 53, AF + ≥2 other risk factors (arterial hypertension, dilatative myocardiopathy, previous TE, biological heart valve) 6; intracardiac thrombosis 1.
Results: LMWH therapy: Nadroparin (Seleparina®) and enoxaparin (Clexane®) in 394 and 28 patients respectively. Comments . One patients with high thromboembolic risk died because of sudden cardiac arrest 13 days after a procedure. TE events (0.6%) occurred in 2 patients with mechanical aortic valve and valvulopathy respectively and treated with s.i.d dose. Incidence of major bleeding is higher in patients treated with LMWH b.i.d but it is in accordance with the data reported in the literature.
Table I
Therapy no OAT LMWH (s.i.d.) LMWH (b.i.d.) s.i.d.=single in die; b.i.d.= bis in die Dose (U/kg) 60.6 (±12.8) 65.9 (±17.4) Patients-number 55 329 93 Complications TE n (%) 0 2 (0.6) 0     arterial 0 2 (0.6) 0     venous 0 0 0 Bleeding n (%) 0 9 (2.7) 7 (7.5)     major 0 4 (1.2) 3 (3.2)     minor 0 5 (1.5) 4 (4.3)