bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast periodic visual stimulation to highlight the relationship between human intracerebral recordings and scalp electroencephalography
Authors: Jacques Corentin , Jonas Jacques , Maillard Louis , Colnat‐Coulbois Sophie , Rossion Bruno , Koessler Laurent 
Published: April 2020

AbstractDespite being of primary importance for fundamental research and clinical studies, the relationship between local neural population activity and scalp electroencephalography (EEG) in humans remains largely unknown. Here we report simultaneous scalp and intracerebral EEG responses to face stimuli in a unique epileptic patient implanted with 27 intracerebral recording contacts in the right occipitotemporal cortex. The patient was shown images of faces appearing at a frequency of 6 Hz, which elicits neural responses at this exact frequency. Response quantification at this frequency allowed to objectively relate the neural activity measured inside and outside the brain. The patient exhibited typical 6 Hz responses on the scalp at the right occipitotemporal sites. Moreover, there was a clear spatial correspondence between these scalp responses and intracerebral signals in the right lateral inferior occipital gyrus, both in amplitude and in phase. Nevertheless, the signal measured on the scalp and inside the brain at nearby locations showed a 10‐fold difference in amplitude due to electrical insulation from the head. To further quantify the relationship between the scalp and intracerebral recordings, we used an approach correlating time‐varying signals at the stimulation frequency across scalp and intracerebral channels. This analysis revealed a focused and right‐lateralized correspondence between the scalp and intracerebral recordings that were specific to the face stimulation is more broadly distributed in various control situations. These results demonstrate the interest of a frequency tagging approach in characterizing the electrical propagation from brain sources to scalp EEG sensors and in identifying the cortical sources of brain functions from these recordings.
α2AP is associated with the development of lupus nephritis through the regulation of plasmin inhibition and inflammatory responses
Authors: Kanno Yosuke , Miyashita Mei , Seishima Mariko , Matsuo Osamu 
Published: April 2020

AbstractIntroductionLupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE), which is a chronic autoimmune disease. However, the detailed mechanisms underlying this disorder have remained unclear. Alpha2‐antiplasmin (α2AP) is known to perform various functions, such as plasmin inhibition and cytokine production, and to be associated with immune and inflammatory responses.MethodsWe investigated the roles of α2AP in the pathogenesis of LN using a pristane‐induced lupus mouse model.ResultsThe levels of plasmin‐α2AP complex and α2AP were elevated in the lupus model mice. In addition, α2AP deficiency attenuated the pristane‐induced glomerular cell proliferation, mesangial matrix expansion, collagen production, fibrin deposition, immunoglobulin G deposition, and proinflammatory cytokine production in the model mice. We also showed that interferon‐γ (IFN‐γ), which is an essential inducer of LN, induced α2AP production through the c‐Jun N‐terminal kinase (JNK) pathway in fibroblasts. In addition, plasmin attenuated the IFN‐γ‐induced proinflammatory cytokine production through the AMPK pathway in macrophages, and α2AP eliminated these effects. Furthermore, we showed that α2AP induced proinflammatory cytokine production through the ERK1/2 and JNK pathways in macrophages.Conclusionα2AP regulates the inflammatory responses through plasmin inhibition and proinflammatory cytokine production and is associated with the development of LN. Our findings may be used to develop a novel therapeutic approach for SLE.
Development in sprinkler irrigation technology in China*
Authors: Yan Haijun , Hui Xin , Li Maona , Xu Yuncheng 
Published: April 2020

AbstractSince the 1950s, sprinkler irrigation technology in China has gradually realized the localization of key equipment through continuous practice and innovation. A large number of key problems in system design and operation management have been studied and addressed. Remarkable water‐saving and yield increase achievements have been made by sprinkler irrigation in China. At the same time, the continuous improvement of sprinkler irrigation technology has also realized comprehensive benefits in the precision control of water and fertilizer, and has promoted the modernization of China's agriculture and its industrial transformation. In the present paper, the development history of sprinkler irrigation technology in China is reviewed, studies on the basic theory of sprinkler irrigation and the development of sprinkler irrigation equipment are systematically summarized, and research hotspots and new development directions of sprinkler irrigation technology in China are introduced. Finally, prospects and suggestions for the further development of sprinkler irrigation in China are put forward, which provides a basis for the sustainable development of sprinkler irrigation technology. © 2020 John Wiley & Sons, Ltd.
Managing the disconnect: A critical case study of neoliberalism in youth development practice
Authors: Coleman Brett R. 
Published: April 2020

AbstractAimsThis critical ethnography interrogates the influence of neoliberalism on youth development practice as instituted by the evidence‐based practice and positive youth development movements.MethodsI employed participant observation and grounded theory analyses in my role as facilitator of a youth participatory action research program in the context of violence prevention work at a large urban youth development agency.ResultsThe disconnect between professionalized youth development and the lived experience of youth manifested in organizational policies and practices and meant that the agency had to balance competing interests and worldviews, reconcile the need for funding with social justice aims, and cope with the consequences of such conflicts.ConclusionsNeoliberalism exacerbates a disconnect between youth development practice and youth experience, contributing to an epistemic form of violence. Results are discussed in relation to Martín‐Baró liberation framework, which emphasizes the recovery of historical memory, deideologizing everyday experience, and utilizing the virtues of oppressed people.
Helping Yourself before Helping Others: How Sense of Control Promotes Charitable Behaviors
Authors: Xu Qian , Kwan Canice M. C. , Zhou Xinyue 
Published: April 2020

This research elucidates the conditions under which distress appeals can evoke the instinct to help without turning recipients away from uncomfortable situations. Five experiments demonstrated with behavioral evidence that evoking a sense of control by irrelevant causes prior to appeal exposure can increase the likelihood of registering as a volunteer (Studies 1 and 3) and the tendency to donate (Studies 2, 4, and 5) in a subsequent unrelated situation. The authors found that this effect was not evident in the absence of distress and for participants with enhanced distress tolerance. The results further showed that enhanced control increased distress tolerance, which mediated the observed effect on charitable acts but had no impact on self‐efficacy in contributing as a helper. The findings have both theoretical and managerial implications for promoting charitable behaviors.
Lipid conversion of Scenedesmus rubescens biomass into biodiesel using biochar catalysts from malt spent rootlets
Authors: Tsavatopoulou Vasiliki D , Vakros John , Manariotis Ioannis D 
Published: April 2020

AbstractBACKGROUNDMicroalgae are considered a third–generation raw material for biofuel production. This work compared the conversion of the extracted oil from the freshwater microalgae Scenedesmus rubescens via transesterification for the production of biodiesel. Considering the cost of biodiesel production, heterogeneous catalysts present a significant advantage because of their stability and reusability. Biochar and modified biochar with H2SO4 were used as catalysts.RESULTSBiochar (BC) was pyrolyzed at 850 °C, under limited oxygen conditions, and was activated by sulphuric acid (H–BC). The catalyst: oil mass ratios tested were from 0 to 0.7:1 for BC, and from 0 to 1:1 for H–BC. The biochar sample exhibited a strong buffer capacity in the pH range between 7 and 5.5, while the acid treated biochar was strongly acidic and could neutralize a significant amount of bases. The produced methyl esters are almost the same in all cases examined. BC samples gave better transesterification results, as far as it concerns the conversion, compared to H–BC.CONCLUSIONThe enhanced activity of the BC with mass used may be correlated with the basic minerals presented on the biochar surface. Raw biochar gave better conversion results (47%) during transesterification compared to the modified biochar with H2SO4 (24%) with better catalyst to molar ratio, 0.7:1 and 0.1:1, respectively. © 2020 Society of Chemical Industry
Hepatic venous Doppler assessment can anticipate simplified pulmonary embolism severity index and right ventricle dysfunction in patients with acute pulmonary embolism
Authors: Acar Emrah , Izci Servet , Inanir Mehmet , Yilmaz Mehmet F. , Izgi Ibrahim A. , Gokce Mustafa , Kirma Cevat 
Published: April 2020

AbstractPurposeAcute pulmonary embolism (APE) is a life‐threating cardiothoracic thromboembolic emergency in which right ventricle dysfunction (RVD) is a major concern. In the present study, we examined the hepatic veins (HVs) blood flow with pulsed‐wave spectral Doppler ultrasonography to determine its relationship with the simplified pulmonary embolism severity index (sPESI) and the patient's RVD status.MethodsWe divided the 243 patients who met the inclusion criteria into two groups based on both their sPESI scores and their RVD status. Transthoracic echocardiography was performed to evaluate the RVD and the HVs within 1 hour after patient admission. The liver was evaluated using subcostal and intercostal echocardiographic windows in grayscale B‐mode, and HVs were assessed using color and spectral Doppler assessment though the same echocardiographic windows.ResultA cut‐off value of the systolic reverse flow velocity‐time integral (SrVTI) = 2.2 cm carried a sensitivity and specificity of 84.29% and 74.89%, respectively, for the prediction of sPESI ≥ 1. A SrVTI cut‐off value of 2.1 cm yielded a sensitivity and specificity of 83.03% and 73.91%, respectively, for the prediction of RVD.ConclusionHV Doppler assessment could be a useful method for anticipating the sPESI and the presence of RVD in patients with APE. In addition, it may provide information regarding the hemodynamic impact of APE.
Discontinuation or reduction in benzodiazepine use by treatment with the traditional herbal medicine Hangekobokuto, case reports
Authors: Yoshinaga Ryo , Maki Toshinobu , Goto Yusuke , Inoue Hiroki , Yano Hiromi , Tahara Eiichi 
Published: April 2020

AbstractIn this report, we present two cases in which benzodiazepines (BZDs) were able to be successfully reduced or discontinued by treatment with traditional Japanese herbal medicine (Kampo medicine), including Hangekobokuto (HKT). These two patients with long‐term use of BZDs due to mental disorders suffered epigastric symptoms. After starting Kampo therapy including HKT, their epigastric symptoms were improved and they were able to reduce or discontinue the use of BZDs. This suggests that HKT is a potentially promising substitutive pharmacotherapy for patients with long‐term use of BZDs. HKT should be considered as a treatment for patients with mental disorders who have taken BZDs for a long time and suffer from medically unexplained epigastric symptoms.
Does social media elevate supply chain importance? An empirical examination of supply chain glitches, Twitter reactions, and stock market returns
Authors: Schmidt Christoph G. , Wuttke David A. , Ball George P. , Heese Hans Sebastian 
Published: April 2020

AbstractWe build upon supply chain management and social media research by exploring the Twitter response to supply chain glitches and how this response may moderate the relationship between supply chain glitches and stock market returns. We analyze data on 213 supply chain glitches for 150 firms across 5 years and over 2 billion tweets on publicly traded firms. Leveraging event study methodology, we find support for our hypotheses. Using both volume and sentiment of tweets, we observe significant reactions on Twitter after supply chain glitches; tweet volume increases and tweets become more negative. We also find that Twitter reactions after a glitch accentuate the relationship between supply chain glitches and stock market returns, demonstrating how social media may elevate the prominence of supply chain problems. To address concerns associated with simultaneity bias, we demonstrate that pre‐stock‐market‐open Twitter activity preempts post‐stock‐market‐open returns. Finally, we conduct post hoc analyses that explore how firms can leverage Twitter to counteract the negative stock market consequences of Twitter, and how firm proximity to the end customer may influence how tweets moderate the stock market reaction to glitches.
A noninvasive system‐level model order reduction scheme for flexible multibody simulation
Authors: Naets Frank , Devos Thijs , Humer Alexander , Gerstmayr Johannes 
Published: April 2020

AbstractThis paper presents a novel system‐level model order reduction scheme for flexible multibody simulation, namely the system‐level affine projection (SLAP). Contrary to existing system‐level model order reduction approaches for multibody systems simulation, this methodology allows to obtain a constant reduced order basis which can be obtained in a noninvasive fashion with respect to the original flexible multibody model. It is shown that this scheme enables an automatic joint constraint elimination which can be obtained at low computational cost through exploitation of the component level modes typically employed in flexible multibody simulation. The equations of motion are derived such that the computational cost of the resulting SLAP model is independent of the original model size. This approach results in a set of ordinary differential equations with a constant mass matrix and nonlinear internal forces. This structure makes the resulting model suitable for a range of estimation, control, and design applications. The proposed approach is validated numerically on a flexible four‐bar mechanism and shows good accuracy for a very low‐order SLAP model.
Comparative performance of carbon nanotube and nanoclay on thermal properties and flammability behavior of amorphous polyamide/SEBS blend
Authors: Paes Letícia Helena Gasparini , Steffen Teresa Tromm , Becker Daniela 
Published: April 2020

AbstractMultiwall carbon nanotubes (CNT) or montmorillonite clay (MMT‐30B) were added to a poly(hexamethylene isophthalamide‐co‐terephthalamine) (an amorphous polyamide ‐ aPA) and styrene‐ethylene/butylene‐styrene graphitized with maleic anhydride (SEBS) blend, in different concentrations, in order to investigate the morphology, thermal properties and flammability behavior. Different nanoparticle localizations in the phase blend were observed through transmission electronic microscopy. CNT nanoparticles are localized in SEBS phase, and MMT‐30B nanoparticles in aPA phase. No significant changes were observed on transition temperatures and thermal stability with both nanoparticle additions. However, a slight increase on storage modulus for clay nanocomposites and a slight reduction for carbon nanotube nanocomposites were observed, due to their different phase localizations. Regarding flammability, CNT nanocomposites showed better performance as a flame retardant when compared to samples with MMT‐30B. Although the MMT‐30B nanocomposites could not be classified according to the UL‐94 criteria, no dripped flaming particles were observed, due to the a char barrier formation on the polymer surface. The CNT nanocomposites were classified according to the UL‐94 criteria as V‐2. The CNT's selective localization on the SEBS phase decreases its heat‐release rate, but no interconnected network structure was formed in the matrix to suppress the dripping flaming particles.
A theoretical elucidation for the formation of unusual zwitterionic sandwich and terminal ruthenium complexes
Authors: Huo Rui‐Ping , Zhang Xiang , Zhang Cai‐Feng 
Published: April 2020

AbstractThe transformation mechanism of the ruthenium azido isocyanide [CpMe5Ru(CNAr)2N3] (Ar = 2,6‐dimethylphenyl) toward cyanamido ruthenium complexes was investigated by M11 calculations. Coordination‐unsaturated complex CpMe5Ru(L)‐CN(N3)Ar (A), coordination‐saturated complex CpMe5Ru(L2)‐CN(N3)Ar (B), and highly coordination‐unsaturated complex CpMe5Ru‐NC(N3)Ar (C) were the key intermediates that lead to cyanamido ruthenium species 3 and unusual sandwich zwitterionic ruthenium complex 4, via different transformation pathways. The theoretical results satisfactorily explained the experimental facts.
Lipid‐based gene delivery to macrophage mitochondria for atherosclerosis therapy
Authors: Zakirov Felix H. , Zhang Dongwei , Grechko Andrey V. , Wu Wei‐Kai , Poznyak Anastasia V. , Orekhov Alexander N. 
Published: April 2020

AbstractAtherosclerosis with associated cardiovascular diseases remains one of the main causes of disability and death worldwide, requiring development of new solutions for prevention and treatment. Macrophages are the key effectors of a series of events involved in atherogenesis, such as inflammation, plaque formation, and changes in lipid metabolism. Some of these events were shown to be associated with mitochondrial dysfunction and excessive mitochondrial DNA (mtDNA) damage. Moreover, macrophages represent a promising target for novel therapeutic approaches that are based on the expression of various receptors and nanoparticle uptake. Lipid‐based gene delivery to mitochondria is considered to be an interesting strategy for mtDNA damage correction. To date, several nanocarriers and their modifications have been developed that demonstrate high transfection efficiency and low cytotoxicity. This review discusses the possibilities of lipid‐based gene delivery to macrophage mitochondria for atherosclerosis therapy.
Geographical distribution and molecular insights into abamectin and milbemectin cross‐resistance in European field populations of Tetranychus urticae
Authors: Xue Wenxin , Snoeck Simon , Njiru Christine , Inak Emre , Dermauw Wannes , Van Leeuwen Thomas 
Published: April 2020

AbstractBACKGROUNDMilbemectin and abamectin are frequently used to control the spider mite Tetranychus urticae. The development of abamectin resistance in this major pest has become an increasing problem worldwide, potentially compromising the use of milbemectin. In this study, a large collection of European field populations was screened for milbemectin and abamectin resistance, and both target‐site and metabolic (cross‐)resistance mechanisms were investigated.RESULTSHigh to very high levels of abamectin resistance were found in one third of all populations, while milbemectin resistance levels were low for most populations. The occurrence of well‐known target‐site resistance mutations in glutamate‐gated chloride channels (G314D in GluCl1 and G326E in GluCl3) was documented in the most resistant populations. However, a new mutation, I321T in GluCl3, was also uncovered in three resistant populations, while a V327G and L329F mutation was found in GluCl3 of one resistant population. A differential gene‐expression analysis revealed the overexpression of detoxification genes, more specifically cytochrome P450 monooxygenase (P450) and UDP‐glycosyltransferase (UGT) genes. Multiple UGTs were functionally expressed, and their capability to glycosylate abamectin and milbemectin, was tested and confirmed.CONCLUSIONSWe found a clear correlation between abamectin and milbemectin resistance in European T. urticae populations, but as milbemectin resistance levels were low, the observed cross‐resistance is probably not of operational importance. The presence of target‐site resistance mutations in GluCl genes was confirmed in most but not all resistant populations. Gene‐expression analysis and functional characterization of P450s and UGTs suggests that also metabolic abamectin resistance mechanisms are common in European T. urticae populations. © 2020 Society of Chemical Industry
Glyphosate and cancer: the importance of the whole picture
Authors: Berry Colin 
Published: April 2020

AbstractThis commentary does not concern itself with the need for, or the value of glyphosate as an agrochemical: rather it examines the scientific basis for the various conclusions reached at different times by a number of regulatory authorities and by the International Agency on Research on Cancer (IARC). Why do they differ? An appropriate regulatory stance depends critically on the application of good science and consistency in the application of established criteria. Constant reappraisal of the methodology used is essential. © 2020 The Author. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
The mechanism of sublethal chlorantraniliprole exposure causing silkworm pupation metamorphosis defects
Authors: Chen Jian , Lu Zhengting , Li Mengxue , Mao Tingting , Wang Hui , Li Fanchi , Sun Haina , Dai Minli , Ye Wentao , Li Bing 
Published: April 2020

AbstractBACKGROUNDChlorantraniliprole (CAP) is widely used in agriculture and forestry to prevent and control pests. The effects of environmental CAP residue on non‐target insect metamorphosis have not been reported. Our research aimed to investigate the sublethal effect of CAP on larva–pupa transformation in silkworm, and explore the mechanism of sublethal CAP exposure‐mediated pupation metamorphosis defects.RESULTSublethal CAP exposure affected the growth and development of silkworm larvae and caused defects in pupation metamorphosis. After CAP exposure, formation the of prepupa procuticle, ecdysial membrane and new epidermis was inhibited. Also, the level of 20‐hydroxyecdysone (20E) and mRNA levels of the 20E signaling pathway‐related genes EcR, USP, E74, E75 and Ftz‐f1 were significantly reduced. Moreover, genes involved in chitin synthesis, such as ChsA, CDA1 and CDA2, were downregulated. Injection of 20E led to the upregulation of chitin synthesis‐related genes and increased formation of new epidermis in CAP‐treated silkworm. However, injection of 20E failed to prevent downregulation of Ftz‐f1 and the defects in pupation metamorphosis.CONCLUSIONOur results suggested that 20E is a target hormone of CAP exposure‐mediated epidermis formation phenotype. Ftz‐f1 was silenced by CAP and might be a direct target gene of sublethal CAP exposure. Our study provided new evidence of the effects of sublethal CAP exposure on insect development and metamorphosis. © 2020 Society of Chemical Industry