bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Locality Preserving Projection-Based Unsupervised Learning in Predicting the Oil Production for Low-Permeability Reservoirs
Authors: Zhang Yuan , Hu Jinghong , Zhang Qi 
Published: June 2020

Summary
Predicting well production in unconventional reservoirs has attracted much attention in recent years. However, it is still a challenge because of the heterogeneity of the unconventional formation and the uncertain physical properties of rock and the fluid-flow mechanism. Therefore, the objective of our study is to develop an efficient method for production forecast in low-permeability reservoirs. In this paper, we applied a locality preserving projection (LPP) -based machine-learning method to provide a novel way of predicting production in low-permeability reservoirs. Our model preserves the local geometric information inherent in the oil data and hence is capable of seizing its intrinsic nonlinear feature. Through LPP-based analysis, specific parameters (e.g., the total fluid pumped) are verified to have more important impact than others on estimating oil production. We conducted both parameter testing and comparison experiments, with results indicating that the LPP-based method has good applicability and efficiency in reasonably forecasting well production from low-permeability reservoirs. This work provides petroleum engineers an effective method for the prediction of oil production.
WITHDRAWN: Role of Organizations in Preparedness and Emergency Response to Flood Disaster in Bangladesh
Authors: Hossain Babul 
Published: June 2020

Abstract
The present study is to know the role of organizations and make an assessment on their assistance regarding preparedness and emergency response of flood disaster affected people. This study has used a mixed-method approach. Flood-affected people were the respondents to evaluate the organizational role. The study reveals that before the flood in 2017 to minimize the loss and damages, the GOs play a very effective role concerning the arrangement of preparatory meetings and preparing shelter centers, and NGOs play a very useful role in making arrangements for awareness-building training. During the emergency period, the GOs played a comparatively better role in providing CI sheets, agricultural assistance and cash money as relief for establishing housing facilities and emergency support. The NGOs played relatively a better role in providing food, water, clothes, medicine, etc. This study put forward complications such as limited sanctions, disruption of communication, lack of awareness of sufferers, and overlapping. The findings of this study would be a significant for the disaster policymakers, and civil societies.
Upregulation of Pole2 Promotes Clear Cell Renal Cell Carcinoma Progression via AKT/mTOR Pathway and Predicts a Poor Prognosis
Authors: Su Yajuan , Li Changfu , Liu Kun , Wei Liangjun , Li Dechao , Wang Wentao , Xu Yongpeng , Pan Hongxin , Teng Lichen 
Published: June 2020

Abstract
Background: Pole2 gene is a subunit of DNA polymerases localized in the nucleus, which commonly present in DNA repair. The effect of pole2 in renal cell carcinoma (RCC) still remain unclear. Here we investigate its clinical significance, function in RCC cells and possible mechanism of effect.Methods: Using TCGA database, we identified that up-regulation of pole2 is associated with poor prognosis in ccRCC. We analyzed association between pole2 expression and T stage or Fuhrman grade. Thus, we investigate the effects of pole2 down-regulation on proliferation, cell cycles, apoptosis and possible mechanism in cells using lentivirus vector with shPole2.Results: Our study showed overexpression of pole2 in ccRCC samples, compared with normal kidney tissues, moreover, high expression of it related to high Fuhrman grade, also may predict poor prognosis in patients with ccRCC (p < 0.05). In cultured cells, knockdown of pole2 would result in inhibit of cell proliferation, increase the apoptosis of cells and arrest cell cycle at S phase. Importantly, knockdown pole2 can lead to down-regulation of p-mTOR and p-AKT expression.Conclusion: Taken together, our findings suggest that overexpression of pole2 may promote tumorgenesis and progress of ccRCC via AKT/mTOR signaling.
Co-existence of Hypertension and Pre-existing Cardiovascular Disease, Hypertension, and Pre-existing Cardiovascular Disease and Mortality in Patients on Continuous Ambulatory Peritoneal Dialysis
Authors: Wang Xiaoyang , Zhan Xiaojiang , Zhou Qian , Feng Xiaoran , Peng FenFen , Wang Niansong , Wen Yueqiang , Wu Xianfeng 
Published: June 2020

Abstract
Background Little is known about the effect of co-existence of hypertension (HTN) and pre-existing cardiovascular disease (CVD), pre-existing CVD, and HTN on mortality in patients on continuous ambulatory peritoneal dialysis (CAPD).Methods We conducted a retrospective study of 3073 incident Chinese patients on CAPD from five dialysis centers between January 1, 2005 and December 31, 2018 in a real-world setting. The primary and secondary outcomes were all-cause and CVD mortality. The association between co-existence of HTN and pre-existing CVD, pre-existing CVD, and HTN and mortality was analyzed using Cox regression models.Results Over a median of 33.7 months of follow-up, 581 (18.6%) patients died, with 286 (9.3%) CVD mortality. Multinomial logistic regression showed that diabetes mellitus was associated with 6.22 (95% CI 4.46 to 8.68)-time risk of co-existence of HTN and pre-existing CVD After adjusting for the confounding factors, HTN plus CVD, pre-existing CVD, and HTN groups had a higher risk of all-cause mortality (HR 3.98, 95% CI 3.07 to 5.17; HR 2.18, 95% CI 1.27 to 3.74; and HR 1.83, 95% CI 1.47 to 2.28) and CVD mortality (HR 4.68, 95% CI 3.27 to 6.69; HR 2.11, 95% CI 0.96 to 4.63; and HR 1.87, 95% CI 1.37 to 2.54), respectively, compared to the control group. There was no significant interaction between HTN and pre-existing CVD on all-cause and CVD mortality (β = 0.010, P = 0.973; β = 0.058, P = 0.892) in the study population.Conclusions CAPD patients with co-existence of HTN and pre-existing CVD at the start of CAPD are at highest risk of all-cause and CVD mortality, followed by pre-existing CVD patients and HTN patients accordingly, with diabetes mellitus as a robustly predictor for co-existence of HTN and pre-existing CVD.
Genome Wide Analysis and Characterization of Heat Shock Transcription Factors (Hsfs) in French Bean (Phaseolus Vulgaris L.)
Authors: Mallick B. , kumari Meenu , Pradhan S. K. , C. Parmeswaran , Naresh P. , Acharya G. C. 
Published: June 2020

Abstract
Background: Heat shock transcription factors (HSFs) play an important role as transcriptional regulatory proteins against heat stress by controlling the expression of heat responsive genes. French bean is a highly thermosensitive crop and therefore, its genome sequence information segregated, characterized here in terms of heat shock transcription factors alongwith its evolutionary significance. Results: In this study, a total comprehensive set of 29 non-redundant full length HSF genes were identified and characterized from Phaseolus vulgaris L. (PvHSF) genome sequence. Detailed gene information such as chromosomal localization, domain position, motif organization and exon- intron identification were analyzed. All the 29 PvHSF genes were mapped on 8 out of 11 chromosomes indicating the gene duplication occurred in french bean genome. Motif analysis and exon- intron structure found to be conserved in each group which showed conserved structure of PvHSFs and heat induced response is highly influenced by the cytoplasmic proteins. Based on structural features and phylogenetic relationship, the HSF genes were grouped into three classes i.e. A to C and 14 groups. Presence of only one pair of paralog sequence suggests that it may be derived from the duplication event during evolution. Comparative genomics study indicated the influence of whole genome duplication and purifying selection on french bean genome during evolution. In silico expression analysis indicated active role of classs A and B family during abiotic stress condition and higher expression in floral organs. Conclusion: A comprehensive analysis of Heat shock transcription factors resulted 29 non-redundant full length PvHSF genes, which were characterized for their occurrence in genome and functional importance through In silico approach.
Prognostic value of ST2 for MACEs and all-cause mortality in patients with coronary artery disease during a long-term follow up
Authors: Li Man , Liu Hongbin , Duan Lei , Cai Yulun , Hao Benchuan , Chen Jianqiao , Li Huiying 
Published: June 2020

Abstract
PurposeST2 has been proved the prognostic value in acute coronary syndrome (ACS), its prognostic value to predict cardiac events in established coronary artery disease (CAD) patients is unknown. The study ought to investigate the prognostic value of ST2 in patients with established coronary artery disease.MethodsA total of 3650 consecutive patients were included in the study. The primary end point was major adverse cardiovascular events (MACEs). The secondary end point was all-cause death. To explore competing risks, cause-specific hazard ratios were obtained using Cox regression models.ResultsDuring a median follow up of 6.4 years, there were 775 patients had the occurrence of MACEs and 275 patients died. Kaplan–Meier survival estimates indicated that the patients with higher level of ST2 (ST2 > 19 ng/ml) had a significantly increased risk of MACEs (log-rank p<0.001)and all-cause death(log-rank p<0.001). After adjustment for potential confounders, multiple COX regression models showed that higher level of ST2 was an independent predictor in developing MACEs(HR 1.31; 95% CI: 1.13–1.52; p<0.001) and all-cause death(HR 1.78; 95% CI: 1.38–2.30; p<0.001). We saw a significant increase of AUC in ROC curve after addition of GDF-15 to a clinical model 0.586 vs 0.619 For MACEs (p<0.001).For long-term all-cause death the increase of AUC 0.766 vs 0.642 (95% CI 0.787–0.846(p<0.001).ConclusionHigher level of ST2 is significantly associated with long-term all-cause death, MACEs and provides incremental prognostic value beyond traditional risks factors.
Recurrence of ameloblastoma in an autogenous bone graft 10 years after initial operation: A case report and literature review
Authors: wu si , Yan Hui , Han Lin , Yu Huaizhou 
Published: June 2020

Abstract
Background: Ameloblastoma is an asymptomatic locally invasive slow-growing odontogenic epithelial tumor. it is rare that the tumor developing in the autogenous bone graft.Case presentation: This report describes a case of ameloblastoma recurrence in an autogenous iliac bone graft 10 years after initial operation in a 37-year-old female who had a history of partial mandibulectomy + left iliac bone graft for ameloblastoma. In 2016 year, the patient was therefore admitted to our hospital for a second surgery, In 2017, 2018, 2019 after the second surgery, radiograph examination showed no recurrence after the surgery.Conclusions: Awareness of the concept of tumor-free operation, extensively resect the affected bone and soft tissue may help in ameloblastoma recurrence, Pathological diagnosis and long-term regular follow-up visits should help improve long-term outcome
Magnitude and associated factors for attitude and practice of Southern Ethiopian residents toward COVID-19 and its preventions: A community based cross sectional study
Authors: Mola Simeneh , Aweke Zemedu , Jemal Bedru , Hussein Robel , Hailu Sileshi , Neme Derartu , Mulugeta Hailemariam , Zemedkun Abebayehu 
Published: June 2020

Abstract
Background: COVID-19 first broke out in china, Hubei province on December 29, 2019. Since then it took more than hundred thousand lives worldwide. Although all countries are taking varying degree of measures to curb the dissemination, the virus is still spreading rapidly in all part of the world. Adherence of peoples for COVID-19 precautions measures is one of the most important factors which determine the effectiveness of curbing the spread. However without having good attitude adherence of people toward precaution measures could be challenging. Therefore the aim of this study is to assess the attitude, practice and associated factors of southern Ethiopian residents toward COVID-19 and its prevention. Methods: A community based cross sectional study was conducted among 585 Southern Ethiopian residents. Bivariate and multivariate binary logistic regression was used to determine association between dependent and independent variables. Adjusted odds ratio with their 95% CI was used show the strength of association. P-value < 0.05 was used to decide statistically significant association.Result: Most of the study participants (90.3%) have good attitude toward COVID-19 and its prevention. Being younger age group, having chronic medical illness, using television as a source of information and having good knowledge were significantly associated with good attitude toward COVID-19.On other hand; only 20% of the study participants have good practice toward COVID-19 prevention. Educational status, occupation and having chronic medical illness, uses of religious teaching as information sources are associated factors for good practice against COVID-19 infection. Conclusion: We conclude that despite the presence good attitude in majority of respondents much work needed to improve rare practice of COVID-19 preventive measures.
The impact of leptomeningeal collaterals in acute ischemic stroke
Authors: Fatima Nida , Saqqur Maher , Shuaib Ashfaq 
Published: June 2020

Abstract
Objectives: Leptomeningeal collaterals provide an alternate pathway to maintain cerebral blood flow in stroke to prevent ischemia, but their role in predicting outcome is still unclear. So, our study aims at assessing the significance of collateral blood flow (CBF) in acute stroke. Methods: Electronic databases were searched under different MeSH terms from Jan 2000 to Feb 2019. Studies were included if there was available data on good and poor CBF in acute ischemic stroke (AIS). The clinical outcomes included were modified rankin scale (mRS), recanalization, mortality, and symptomatic intracranial hemorrhage (sICH) at 90 days. Data was analyzed using random-effect model.Results: A total of 47 studies with 8,194 patients were included. Pooled meta-analysis revealed that there exist 2-fold higher likelihood of favorable clinical outcome (mRS≤2) at 90 days with good CBF compared with poor CBF (RR: 2.27; 95%CI: 1.94-2.65; p<0.00001) irrespective of the thrombolytic therapy [RR with IVT: 2.90; 95%CI: 2.14-3.94; p<0.00001, and RR with IAT/EVT: 1.99; 95% CI: 1.55-2.55; p<0.00001]. Moreover, there exists 1-fold higher probability of successful recanalization with good CBF (RR: 1.31; 95% CI: 1.15-1.49; p<0.00001). However, there was 54% and 64% lower risk of sICH and mortality respectively in patients with good CBF in AIS (p<0.00001).Conclusions: The relative risk of favorable clinical outcome is more in patients with good pretreatment CBF. This could be explained due to better chances of recanalization, combined with lesser risk of intracerebral hemorrhage in good CBF status.
Measuring Conference Attendees’ Satisfaction: An Insight from Libya
Authors: Atia Ahmed , Abired Ahmed , Elshwekh Halla , Elmarzugi Nagib 
Published: June 2020

Abstract
Background and objectives: Even with the widespread repetition of organizing events and conferences by hosting organizations, little is known about the influence of such meeting on attendee’s satisfaction. However, up to our knowledge, there is no exploratory survey measured the satisfaction of conference attendees in Libya. Hence, this study sought to reveal the that impact of the effectiveness of conference messages on the attendee's satisfaction. Methods: A self-report survey designed to assess satisfaction with conference attributes was completed by 78 attendees following their participation in the 3rd Libyan conference on medical and pharmaceutical sciences held in Libya. The questionnaires were circulated through personal contact with respondents at the conference. Results: Based on data analysis, the lowest mean values ranging between “Poor satisfaction” and “fair” (from 2.8 to 3.4) have the attributes: networking, venue of the conference, and the new knowledge. Furthermore, the highest rating was assigned to the conference organization and quality of service, technical support, and conference program. Generally, it is obvious that the attendees are not completely satisfied with the conference in general and specifically with some conference attributes, which are related to the networking and the conference venue. Conclusion: The results of this study suggest that the organizer should pay more attention to the venue selection process, as it affects overall quality of the conference. Further comparable studies, regarding conference satisfaction should be conducted in other conference venues and settings in Libya, in order to raise the quality of services destination attractiveness.
Detection of amyloid-beta and tau in tear fluid of patients with Alzheimer’s disease
Authors: Gijs Marlies , Ramakers Inez H.G.B. , Visser Pieter Jelle , Verhey Frans R.J. , Waarenburg Marjo P.H. van de , Schalkwijk Casper G. , Nuijts Rudy M.M.A. , Webers Carroll A.B. 
Published: June 2020

Abstract
Background There is growing interest in finding non-invasive alternatives to cerebrospinal fluid (CSF) that could serve as front-line diagnostics for Alzheimer’s disease (AD). In this study, we investigated AD-specific biomarkers in tear fluid.Methods Tear fluid was collected from 25 patients with subjective cognitive decline SCD), 24 patients with mild cognitive impairment (MCI), 11 dementia patients and nine controls. Amyloid-beta peptides (AB38, AB40, AB42), t-tau and p-tau levels in tear fluid were determined using multiplex immunoassays.Results Tear t-tau levels in dementia, MCI and SCD patients were higher than in HC (p = 0.002, p = 0.002 and p = 0.013, respectively). A negative correlation between AB42 and t-tau was found in both tear fluid and CSF. Levels of tear p-tau were detectable in patients but not in HC.Conclusions This study shows for the first time presence of amyloid-beta peptides (AB38, AB40, AB42), t-tau and p-tau in tear fluid.
Indiscriminate use of agro-veterinary pesticides in plague endemic foci in Tanzania: potential risk for development of insecticide resistance in flea vectors
Authors: Rugalema Grace , Mnyone Ladslaus 
Published: June 2020

Abstract
Background: Agro-veterinary pesticides are increasingly associated with the development of resistance in arthropod disease vectors. However, no has been conducted so far to assess such risk in flea vectors despite the indiscriminate use of pesticides in plague endemic foci in Tanzania.Methods: We identified risk factors associated with the use of agro-veterinary pesticides, which could enhance development of resistance in flea vectors in two plague endemic districts, using structured questionnaire and direct observations.Results: Excessive and injudicious use of agricultural and veterinary pesticides was common in both Lushoto and Mbulu district. Most farmers (80%, n=73) were applying agricultural pesticides over three times per cropping season, did not adhere to manufacturers recommended doses, and had limited or no knowledge on safety procedures and adverse effects associated with pesticides. Up to 49% were applying pesticides more than twice the recommended doses. About 91% of respondents in Lushoto and 93% respondents in Mbulu reported using agricultural pesticides. The three (3) out of fourteen (14) most commonly used agricultural pesticides in Lushoto were master kinga72WP (mancozeb 640g/kg+cymoxanil 80g/kg) (44%), suracron720EC (profenos 500g/l EC) (25.3%) and Sumo 5EC (lambda-cyhalothrin) (18.7%). The three (3) out of seventeen (17) most commonly used agricultural pesticides in Mbulu were Dursban50W (Chlorpyrifos) (29%), Duduban 450EC (Cypermethrin 10g/lt+chloropyrifos 35g/lt) (18%) and Dursban+farmerzeb (Chlorpyrifos 48%, Mancozeb 80%WP). Cybadip (Cypermethrin) (≥45%) and paranex (alphacypermethrin) (≥13%) were the most commonly used livestock pesticides.Conclusion: This study identified injudicious uses and/or other malpractices, which enhance contamination of environments/surfaces with pesticides and consequently the exposure of flea vectors. Therefore, the flea vector populations in Lushoto and Mbulu districts are putatively under high risk of resistance development. Further studies are underway to confirm the insecticide resistance status, unravel distribution of the resistance, and involved resistance mechanisms.
Clinical Characteristics of Non-Pneumonia COVID-19 Adults in Shanghai, China
Authors: Ji Haiying , Hu Lijuan , Li Tao , Gong Linjing , Wu Xu , Shen Qinjun , Jiang Zhilong , Zhu Lei 
Published: June 2020

Abstract
Background: Since December 2019, coronavirus disease 2019 (COVID-19) rapidly spread throughout the whole world , data have been needed on the clinical characteristics of the affected patients.Objectives: A total of 579 adult COVID-19 cases were enrolled in Shanghai from Jan 20 to Apr 15, 2020, in which 95 cases (16.41%) showed non-pneumonia on CT when confirmed. The characteristics of non-pneumonia cases have not been clearly described previously, and this might provide guidance to prevent and treatment of COVID-19.Method: We retrospectively collected the patient clinical dataset including demography, epidemiology, clinical manifestation, laboratory test results, diagnostic classification, treatment and clinical outcomes.Results: The average age of 95 COVID-19 cases was 31.45 ± 12.89 years old and 95.79% of them were less than 60 years old. They had mild clinical symptoms and/or laboratory abnormalities. 20 of the 95 cases occurred mild pneumonia during hospitalization, accompanied with lower lymphocyte counts, in which 60% cases were complicated with underlying condition and 15% cases were over 60 years old. All cases were cured. 16 of the 95 cases were local residents with clear epidemiological history and long incubation time, and mainly discovered as fever and respiratory symptoms. Other 79 cases were overseas imported, some had initial symptoms of diarrhea, smell or taste disorders and so on. They were mainly found at port of entry.Conclusions: Non-pneumonia COVID-19 predominantly occurred among young adults with mild clinical symptoms and possible long incubation time. The patients with underlying condition or at older age more likely developed mild pneumonia after diagnosis. Thereby, it is very important to pay attention to these patients and make reasonable diagnostic classification towards better prevention and treatment of COVID-19.
Hypoplastic left heart syndrome with endomyocardial fibroelastosis diagnosed in first trimester: A case report
Authors: Yang Shuihua , Yang Zuo-jian , Pang Yu-lan , Liang Meng-feng , Qin Gui-chan , Tian Xiao-xian , Li Xin-yan 
Published: June 2020

Abstract
Background Report a case of hypoplastic left heart syndrome (HLHS) with endomyocardial fibroelastosis (EFE) diagnosed in the first trimester. Case presentation We detected a balloon shaped left ventricle, a narrowed reverse blood stream signal in the aortic arch and widened blood stream signals in the pulmonary artery (2.2 mm) and the ductus arteriosus when performing echocardiographic screen with transabdominal sonography in a 31-year-old pregnant woman (gravida 2, para 1) who presented to our department for routine fetal ultrasonography at 11+2 weeks’ gestation. Based on these findings, a diagnosis of HLHS with EFE was suspected. The findings from autopsy confirmed the diagnosis. Conclusion Ultrasound screening in the first trimester may be helpful in early diagnosis of HLHS.