bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of mushroom (Pleurotus eryngii) flour upon quality attributes of wheat dough and functional cookies‐baked products
Authors: Biao Yuan , Chen Xin , Wang Song , Chen Guitang , Mcclements David Julian , Zhao Liyan 
Published: December 2019

AbstractThe objective of this study was to create a healthier version of a commonly consumed baked food (cookies) by replacing some of the wheat flour with a nutraceutical‐rich mushroom flour. The impact of incorporating different levels of powdered mushroom (Pleurotus eryngii) flour on the rheological properties of the cookie dough and the final cookies was therefore determined. The rheological properties of wheat dough supplemented with 0%–25% (w/w) of mushroom flour were analyzed using a Mixolab instrument and a shear rheometer. Increasing the ratio of mushroom‐to‐wheat flour in the doughs increased the peak and final viscosities, but decreased dough stability and elastic modulus. Sensory evaluation using an orthogonal test showed that 15% mushroom flour, 10% maltodextrin, and 1.5% sodium bicarbonate were the optimal composition for producing cookies with the best sensory score. In conclusion, our results showed that cookies with acceptable textures and appearances could be produced by replacing up to 15% of wheat flour with mushroom flour.
Tectono‐magmatic division of the Late Ordovician (Sandbian) volcanism at the south‐western margin of Baltica using immobile trace elements: Relations to the plate movements in the Iapetus Palaeo‐Ocean
Authors: Kiipli Tarmo , Hints Rutt , Kallaste Toivo , Nielsen Arne T. , Pajusaar Siim , Schovsbo Niels H. 
Published: December 2019

Immobile trace elements in K‐bentonites indicate three volcanic stages during the Sandbian Stage of the Late Ordovician:
Early Grefsen is characterised by high‐Ti source magmas alternating with a few high‐Zr layers.
Middle Grefsen is characterised by overall low‐Ti source magmas with multiple high‐Zr layers alternating with less frequent low‐Zr layers.
Late Grefsen to Early Katian is characterised by a low content of all studied immobile trace elements (Ti, Zr, Nb, and Th).
In all K‐bentonites, the Nb/Al2O3 ratio indicates subalkaline volcanism dominated by rhyolites. In the Early Grefsen stage, andesites and dacites occur. The TiO2/Al2O3 versus Zr/Al2O3 discrimination diagram suggests low‐ and high‐temperature magmatism. Low‐temperature magmatism may have occurred during subduction of water‐rich oceanic sediments in the frontal arc of Avalonia and high‐temperature magmatism during the overriding of a mid‐ocean ridge or hot spot. The coeval end of the volcanic record in Avalonia and Baltica may indicate the collision of Avalonia with a hypothetical continental crust within the Iapetus Ocean.
Bayesian inference framework for bounded generalized Gaussian‐based mixture model and its application to biomedical images classification
Authors: Alroobaea Roobaea , Rubaiee Saeed , Bourouis Sami , Bouguila Nizar , Alsufyani Abdulmajeed 
Published: December 2019

AbstractBiomedical image classification problem has attracted a lot of attention in medical engineering community and medicine applications. Accurate and automatic classification (eg, normal/abnormal or malignant/benign) has a variety of applications such as automatic decision making and is known to be very challenging. In this research, we address this problem by investigating the effectiveness of Bayesian inference methods for statistical bounded mixture models. Indeed, a novel approach termed as Bayesian learning for bounded generalized Gaussian mixture models is developed. The consideration of bounded mixture models is encouraged by their capability to take into account the nature of the data that is compactly supported. Furthermore, the consideration of Bayesian inference is more attractive compared to frequentist reasoning. In this work, we address main issues related to accurate data classification such as the effective estimation of the model's parameters and the selection of the optimal model complexity. Moreover, the problem of over‐ or under‐fitting is treated by taking into account the uncertainty through introducing prior information about the model's parameters. A comparative study between different Gaussian‐based models is also performed to evaluate the performance of the proposed framework. Experiments have been conducted on challenging biomedical image datasets that involve retinal images for diabetic retinopathy detection and mammograms for breast cancer detection. Obtained results are encouraging and show the benefits of our Bayesian framework.
Credentialing and privileging for clinical pharmacists
Authors: Engle Janet P. , Dick Travis B. , Bryant Ginelle , Ciolek Alana , Crismon M. Lynn , Fisher Justin D. , Lasota Sean , Newsome Andrea Sikora , Thrasher Kimberly , Vest Mary‐Haston , Ward Jessica 
Published: December 2019

AbstractThe American College of Clinical Pharmacy (ACCP) 2019 Certification Affairs Committee was charged with writing a white paper to provide a road map for developing initial and ongoing credentialing and privileging processes for clinical pharmacists. After extensively reviewing the literature, the committee prepared a framework to support organizations in implementing credentialing and privileging programs. This document contains definitions, principles, and a suggested process for credentialing; organizational costs of credentialing and privileging; and barriers associated with the process. Finally, resources are provided to help the reader establish a credentialing and privileging process.
The effects of different bisphenol derivatives on oxidative stress, DNA damage and DNA repair in RWPE‐1 cells: A comparative study
Authors: Kose Ozge , Rachidi Walid , Beal David , Erkekoglu Pınar , Fayyad‐Kazan Hussein , Kocer Gumusel Belma 
Published: December 2019

AbstractBisphenol A (BPA) is a well‐known endocrine disruptor and it is widely used mainly in the plastics industry. Due to recent reports on its possible impact on health (particularly on the male reproductive system), bisphenol F (BPF) and bisphenol S (BPS) are now being used as alternatives. In this study, RWPE‐1 cells were used as a model to compare cytotoxicity, oxidative stress‐causing potential and genotoxicity of these chemicals. In addition, the effects of the bisphenol derivatives were assessed on DNA repair proteins. RWPE‐1 cells were incubated with BPA, BPF, and BPS at concentrations of 0–600 μM for 24 h. The inhibitory concentration 20 (IC20, concentration that causes 20% of cell viability loss) values for BPA, BPF, and BPS were 45, 65, and 108 μM, respectively. These results indicated that cytotoxicity potentials were ranked as BPA > BPF > BPS. We also found alterations in superoxide dismutase, glutathione peroxidase and glutathione reductase activities, and glutathione and total antioxidant capacity in all bisphenol‐exposed groups. In the standard and modified Comet assay, BPS produced significantly higher levels of DNA damage vs the control. DNA repair proteins (OGG1, Ape‐1, and MyH) involved in the base excision repair pathway, as well as p53 protein levels were down‐regulated in all of the bisphenol‐exposed groups. We found that the BPA alternatives were also cytotoxic and genotoxic, and changed the expressions of DNA repair enzymes. Therefore, further studies are needed to assess whether they can be used safely as alternatives to BPA or not.
Longnon‐coding RNA NEAT1 overexpression associates with increased exacerbation risk, severity, and inflammation, as well as decreased lung function through the interaction with microRNA‐124 in asthma
Authors: Li Xueying , Ye Shenglan , Lu Yang 
Published: December 2019

AbstractBackgroundThis study aimed to explore the association of long non‐coding RNA nuclear‐enriched abundant transcript 1 (lncRNA NEAT1) with exacerbation risk, lung function, and inflammatory cytokines in asthma.MethodsA total of 170 patients with asthma in exacerbation, 170 patients with asthma in remission, and 170 healthy controls (HCs) were enrolled, and their plasma samples were collected. The expressions of lncRNA NEAT1 and microRNA‐124 (miRNA‐124) in plasma were detected by real‐time quantitative polymerase chain reaction; inflammatory cytokines in plasma were measured by the Enzyme‐linked immunosorbent assay (ELISA); and pulmonary ventilation function was detected by examination of forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC).ResultsLncRNA NEAT1 expression was upregulated in asthma patients in exacerbation compared with HCs and asthma patients in remission, and receiver operating characteristic curve exhibited that it was of good value in distinguishing asthma patients in exacerbation from HCs (AUC: 0.869 (0.830‐0.908)) and asthma patients in remission (AUC: 0.775 (0.724‐0.825)). Furthermore, lncRNA NEAT1 was positively correlated with exacerbation severity, TNF‐α, IL‐1β, and IL‐17, but negatively correlated with IL‐10, FEV1/FVC and FEV1%predicted in asthma patients. Additionally, lncRNA NEAT1 was negatively correlated with miR‐124, and miR‐124 was negatively associated with exacerbation risk, exacerbation severity, and inflammation, but positively associated with lung function in asthma patients.ConclusionCirculating lncRNA NEAT1 exhibits potential to be a new biomarker for elevated exacerbation risk and severity of asthma.
Remarkably flexible quinazolinones—synthesis and biological applications
Authors: Reddy Manne Madhava , Sivaramakrishna Akella 
Published: December 2019

AbstractEven though several quinazolinone derivatives have been synthesized, still there is a constant demand for designing and synthesis of new quinazolinone derivatives by fine‐tuning the electronic and steric properties of substituents due to their interesting structure‐based biological utilities and the versatile chemistry. While many of the synthetic routes are useful as building blocks in synthetic organic chemistry, the drawbacks of some of these methods like unsatisfactory or variable yields, prolonged reaction times, inadequate tolerance to other substrates, including the use of costly catalysts/reagents. This review article is mainly focused on various synthetic routes for the preparation of quinazolinones, their important properties and applications.
Synthesis and anticancer activity of benzotriazole derivatives
Authors: Li Qiujing , Liu Guijun , Wang Ningning , Yin Huiyong , Li Zhulai 
Published: December 2019

AbstractA series of benzotriazole (BTA) derivatives were synthesized as tyrosine protein kinase inhibitors using fragment‐based design strategy. All desired compounds were synthesized with the reaction of benzotriazole, chloroacetonitrile and aromatic aldehyde using Ultrasonic‐Microwave method and characterized by IR, 1H and 13C‐NMR, mass spectrometry (MS) and elemental analysis. The anticancer activity of these compounds was evaluated by CCK‐8 method against carcinoma VX2, lung cancer A549, stomach cancer cell lines MKN45 and MGC in vitro. The results showed that all compounds showed good antiproliferative activity. In particular, compound 2.1 showed the most prominent inhibition of VX2 cell lines with IC50 of 3.80 ± 0.75 μM. Compound 2.2 exhibited highly potent anticancer activity of stomach MGC cell lines with IC50 of 3.72 ± 0.11 μM. A549 and MKN45 cell lines were sensitive to compound 2.5 with IC50 of 5.47 ± 1.11 and 3.04 ± 0.02 μM, respectively.
Trinity Strikes Back: Monetary Independence And Inflation In The Caribbean
Authors: Cevik Serhan , Zhu Tianle 
Published: December 2019

AbstractMonetary independence is at the core of the macroeconomic policy trilemma. This study examines the relationship between monetary autonomy and inflation in Caribbean countries over the period 1980–2017. The empirical results show that greater monetary policy independence, measured as a country's ability to conduct its own monetary policy for domestic purposes independent of external monetary influences, leads to lower consumer price inflation. This relationship—robust to alternative specifications and estimation methodologies—has clear policy implications, especially for countries that maintain pegged exchange rates relative to the US dollar with a critical bearing on monetary autonomy. © 2019 John Wiley & Sons, Ltd.
Spectroscopic insight into the interplay between structural disorder and oxidation degree in melt‐grown Ce0.5Zr0.5O2‐y compounds
Authors: Oliete Patricia B. , Orera Alodia , Sanjuán María Luisa 
Published: December 2019

AbstractThe oxygen storage capacity of CexZr1‐xO2‐y compounds arises from the mixed‐valent character of cerium, which makes the system sensitive to external factors such as temperature and oxygen partial pressure through their influence in the Ce valence, cation ordering and oxygen content. In this work, we analyze the phase relations in Ce0.5Zr0.5O2‐y compounds fabricated by the laser floating zone technique in either oxidising or reducing atmosphere. Chemical, structural, and microstructural properties are studied by X‐ray diffraction, thermogravimetry, scanning electron microscopy (energy dispersive X‐ray spectroscopy and electron backscatter diffraction), and Raman spectroscopy. The latter proves to be determinant to discriminate between phases arising from subtle variations of atomic distribution that are hardly distinguished by X‐ray diffraction or energy dispersive X‐ray analyses. Cation disordered, fluorite‐like phases are obtained when processing is performed in air, whereas cation‐ordered, pyrochlore‐related phases are formed when processing in Ar+5%H2 atmosphere. Processing in a low but non‐negligible pO2 yields, besides the pyrochlore and fluorite‐like phases, an intermediate state with partial disorder that may be relevant for catalysis applications. The vibrational Raman spectrum of the Ce2Zr2O7 pyrochlore has been fully interpreted through polarisation measurements at room and low temperature. Bands arising from crystal field transitions within the ground and first excited multiplets of Ce3+ ions are also identified. The electronic Raman spectrum is found to be a sensitive probe of the degree of cation and oxygen order in these compounds.
Combining Fourier transform infrared and Raman spectroscopies with Gaussian deconvolution: An improved approach for the characterization of emeralds
Authors: Branca Caterina , Arcovito Armando , Cosio Emanuele , Interdonato Monica , Sabatino Giuseppe , Wanderlingh Ulderico , D'Angelo Giovanna 
Published: December 2019

AbstractIn the present work, five natural emeralds from various localities and one hydrothermal synthetic emerald were investigated by scanning electron microscopy–energy‐dispersive X‐ray technique (SEM–EDX), Raman and Fourier transform infrared (FTIR) attenuated total reflection spectroscopy. A two‐step procedure was used for this study. In the first step, the samples were analyzed by SEM–EDX to evidence differences in the chemical composition and, in particular, to estimate their different alkali contents. In the second step, a detailed vibrational analysis was made, paying a special attention to three specific vibrational bands generally related to the content of alkalis: the infrared OH (3,800–3,400 cm−1) and Si─O (1,000–1,300 cm−1) stretching bands and the Raman band around 1,066 cm−1. In particular, in order to resolve overlapped bands present in these latter two ranges, a peak finding was done by curve fitting with Gaussian functions following a minimizing procedure. This analysis was accomplished by the second and fourth derivative of the FTIR and Raman spectra. These processing procedures allowed us to capture unambiguously spectral vibrational differences related to differences in the chemical composition of the investigated emeralds and, in particular, to their alkali content.
Effects of plant growth regulator application on the malting quality of barley
Authors: McMillan Tricia , Tidemann Breanne D , OʼDonovan John T , Izydorczyk Marta S 
Published: December 2019

AbstractBACKGROUNDLodging can negatively affect yield and quality of barley grain. Synthetic plant growth regulators (PGRs) reduce lodging by producing shorter, thicker, and stronger stems. However, the impact of applying PGRs on malting performance of barley is not known. The objective of this work was to assess the effect of application of three PGRs (ethephon, chlormequat chloride, and trinexapac‐ethyl) in combination with different seeding rates on the malting quality of barley grown in several locations and years in western Canada.RESULTSThe kernel weight in PGR‐treated barley was reduced by 1.7% to 6.5% compared with the nontreated grain. Application of PGRs had no effect on the concentration of proteins and germination energy. Seeding rates significantly affected kernel weight, protein content, and germination index (GI), but no interactions between PGRs and seeding rates were observed. The smaller kernels of ethephon‑ and trinexapac‐treated barley showed good hydration and grain modification during malting, as indicated by high levels of starch‐converting enzymes, high Kolbach indices, and low levels of wort β‐glucans. Overall, the fine extract of malt from PGR‐treated barley was slightly lower than that of the control malt; however, the extract reduction was statistically significant only for chlormequat‑ and trinexapac‐treated barley.CONCLUSIONSThe application of PGRs had significant effects on kernel plumpness and kernel weight, but the effects of PGR application on the malting quality were generally small and insignificant. The decision of PGRs application on malting barley needs to be considered in combination with potential benefits of PGRs in mitigating lodging and their effects on the agronomic performance of barley. © Her Majesty the Queen in Right of Canada 2019
Development of a stir bar sorptive extraction method coupled to solidification of floating droplets dispersive liquid–liquid microextraction based on deep eutectic solvents for the extraction of acidic pesticides from tomato samples
Authors: Nemati Mahboob , Farajzadeh Mir Ali , Mohebbi Ali , Khodadadeian Fariba , Afshar Mogaddam Mohammad Reza 
Published: December 2019

AbstractA stir bar sorptive extraction method coupled with deep eutectic solvent based solidification of floating organic droplets–dispersive liquid–liquid microextraction has been used for the simultaneous derivatization and extraction of some acidic pesticides in tomato samples. In this method, initially the analytes are adsorbed on a coated stir bar from tomato juice filled in a narrow tube. After extraction, the stir bar is removed and a water–miscible deep eutectic solvent is used to elute the analytes. Afterward, a derivatization agent and a water–immiscible deep eutectic solvent (as an extraction solvent) with melting point near to room temperature are added to the obtained eluant at µL–levels and the obtained mixture is rapidly injected into deionized water. Under the optimum conditions, the introduced method indicated high enhancement (1543–3353) and enrichment (2530–2999) factors, low limits of detection (7–14 ng/L) and quantification (23–47 ng/L), good linearity (r2 ≥ 0.9982), and satisfactory repeatabilities (relative standard deviation ≤12% for intra– and inter–day precisions at a concentration of 100 ng/L of each analyte). Finally, the proposed method was applied in analysis of the analytes in tomato samples.
Stakeholders in the medical trade: The case of South Korea's networks with China and the United States
Authors: Cho Heeran J. , Lee Timothy J. 
Published: December 2019

AbstractThis study analyzes the stakeholder networks that have developed in the medical tourism industry centered around South Korea. The network that 14 leading Korean medical tourism stakeholders have with China and the United States are investigated considering General Agreement on Trade in Services four modes and analyzed via social network analysis. The stakeholders of each mode with China and the United States depict relational structures that vary in their degree of similarity and disparity on the basis of their centralization. This study contributes to the literature by bringing order to and providing a structural framework for the network complexity of the medical trade in relation with the medical tourism industry.
Exploring participatory action research as a driver for sustainable tourism
Authors: Goebel Katharina , Camargo‐Borges Celiane , Eelderink Madelon 
Published: December 2019

AbstractThe constantly growing tourism sector does not only bring economic well‐being to host communities but also raises environmental and social questions. Communities increasingly experience negative impacts that strain their social, cultural, and ecological living environments. We investigate the potential of a more relational, action‐oriented research approach for tourism: Participatory Action Research (PAR). Results show that PAR has the potential to actively involve tourism‐affected communities in the decision‐making processes that impact their living environments and facilitate them in co‐creating community‐specific initiatives for sustainable change. Yet, the current role of conventional research approaches hinders PAR in developing its full potential.
The use and cost‐effectiveness of intraoperative navigation in pediatric sinus surgery
Authors: Govil Nandini , Shaffer Amber D. , Stapleton Amanda L. 
Published: December 2019

Objectives/HypothesisThere are consensus statements about when to use intraoperative navigation (IN) in adult sinus surgery. However, no corresponding guidelines exist for pediatrics. Our objectives included: 1) assess the demographic and operative factors associated with IN use and 2) calculate the cost‐effectiveness of IN use.Study DesignRetrospective chart review.MethodsOne hundred nineteen pediatric patients undergoing sinus surgery between 2003 and 2016 were reviewed. Demographic and surgical factors were collected from medical records. Costs associated with use of IN were gathered from billing records.ResultsOf the 119 patients, 60 underwent sinus surgery with navigation (wIN) and 59 underwent surgery without navigation (sIN). Children in the wIN group had more complex surgeries with more sinuses opened (P = .008). Individual attending surgeon and presence of trainee were associated with increased use of IN (P < .001 for both). IN resulted in a median of 31.5 minutes longer surgical time (P < .001). IN had an incremental cost/effectiveness ratio (ICER) of $22,378 for each year without revision surgery for patients with acute disease. However, for patients with chronic disease, the probability of undergoing a second surgery was the same between wIN and sIN groups, and navigation was not cost‐effective (ICER of −$3,583).ConclusionsIN use did not decrease complications or rates of revision surgery. It was used primarily as an educational tool or to increase confidence in intraoperative identification of landmarks. However, the use of IN added surgical time and was not cost‐effective. Further research must be completed to determine when IN is indicated in pediatric sinus surgery.Level of Evidence4Laryngoscope, 2019