bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased risk of cardiovascular death in breast cancer patients without chemotherapy or (and) radiotherapy: a large population-based study.
Authors: Guan Tianwang , Zhang Hanbin , Yang Jinming , Lin Wenrui , Wang Kenie , Su Miao , Peng Weien , Li Yemin , Lai Yanxian , Liu Cheng 
Published: August 2020

Abstract
Background

Cardiovascular death (CVD) in breast cancer patients without chemotherapy or (and) radiotherapy has not been studied yet. This study evaluates the correlation between breast cancer and CVD risk independent of chemotherapy (CT) or (and) radiotherapy (RT).
Methods

Data of female breast cancer patients without receiving CT or RT were retrieved from the Surveillance, Epidemiology, and End Result (SEER) database (2004–2015). Data were divided into two cohorts: Patients who underwent tumor resection (resection cohort) and those who didn’t undergo resection (no resection cohort). The CVD risk in patients was expressed as standardized mortality ratios (SMRs). A 1:1 propensity score matching (PSM) was applied to balance inter-group bias, and competing risk regressions were utilized to evaluate the impact of tumor resection on CVD.
Results

The CVD risk was significantly higher (SMR = 2.196, 95% CI:2.148–2.245, P < 0.001) in breast cancer patients who did not receive CT or RT compared to the general population. Breast cancer patients who did not undergo tumor resection showed a higher CVD risk than patients who underwent tumour resection (tumor resection SMR = 2.031, 95% CI: 1.983–2.079, P < 0.001; no resection SMR = 5.425, 95% CI:5.087–5.781, P < 0.001). After PSM, the CVD risk among patients without tumor resection indicated an increase of 1.165-fold compared to the patients with tumor resection (HR = 1.165, 95% CI: 1.039–1.306, P = 0.009).
Conclusions

Female breast cancer patients are at higher risk of CVD despite unexposure to cardio-toxic CT or RT. However, female breast cancer patients subjected to tumor resection have decreased CVD risk. This study suggests that monitoring female breast cancer patients not receiving RT or CT might serve as a preventative measure against CVD.
Sex and Nest Type Influence Avian Blood Parasite Prevalence in a High Elevation Bird Community
Authors: Rodriguez Marina D. , Doherty Paul F. , Piaggio Antoinette J. , Huyvaert Kathryn P. 
Published: August 2020

Abstract
Background - Prevalence of avian haemosporidian parasites and the factors influencing infection in the Colorado Rocky Mountains are largely unknown. With climate change expected to promote the expansion of vector and avian blood parasite distributions, baseline knowledge and continued monitoring of the prevalence and diversity of these parasites is needed. Methods - Using an occupancy modeling framework, we conducted a survey of haemosporidian parasite species infecting an avian community in the Colorado Rocky Mountains in order to estimate prevalence and diversity of blood parasites and to investigate species-level and individual-level characteristics that may influence infection. Results - We estimated prevalence and diversity of avian haemosporidia across 24 bird species, detecting 39 parasite haplotypes. We found that open cup nesters have higher Haemoproteus prevalence than cavity or ground nesters. Additionally, we found that male Ruby-crowned Kinglets, White-crowned Sparrows, and Wilson’s Warblers have higher Haemoproteus prevalence compared to other host species. Conclusions - Our study presents baseline knowledge of haemosporidian parasite presence, prevalence, and diversity among avian species in the Colorado Rocky Mountains and adds to our knowledge of host-parasite relationships of blood parasites and their avian hosts.
Efficacy and safety of jakinibs in rheumatoid arthritis: A systematic review and meta-analysis
Authors: Yin Yufeng , Liu Mengru , Chang Xin , He Michun , Wang Mingjun , Wu Jian 
Published: August 2020

Abstract
Objectives

To assess the efficacy and safety of jakinibs for the treatment of active rheumatoid arthritis (RA) in patients with an inadequate response or intolerance to conventional synthetic or biologic disease-modifying antirheumatic drugs (DMARDs).

Methods

A systematic search was conducted in PubMed, Embase and the Cochrane Library. Randomized placebo-controlled trials (RCTs) of jakinibs in RA patients were eligible. The effective outcome was RA improvement to reach an American College of Rheumatology 20%/50%/70% (ACR20/50/70) response rate at week 12 and 24 after treatment. The safety outcomes included treatment-emergent adverse events (TEAEs), serious adverse events (SAEs), discontinuations due to adverse events, infections and serious infections.

Results

Twenty-eight randomized, double-blind, controlled trials including 14500 patients were included. Both at week 12 and 24, the pooled analysis was suggestive of an effective treatment with jakinibs, represented as the increased clinical response of ACR20, ACR50 and ACR70. The subgroup analysis based on different types of jakinibs demonstrated that only peficitinib treatment had no impact on the clinical response of ACR50 or ACR70 at week 12. Jakinibs were associated with an increased incidence of infections at week 12 and TEAEs and infections at week 24. No increase in the risk of SAEs, discontinuations due to adverse events, or serious infections was observed in comparisons between treatment with jakinibs and treatment with placebo in these patients.

Conclusions

Jakinibs are efficacious and well tolerated in RA patients up to a period of 24 weeks, although they are associated with an increased risk of infectious complications.
Consecutive Observation of Dynamic Metastases of Human Ovarian Carcinoma to Grading Lymph Nodes in Mouse Model
Authors: Du Licheng , Kong Fenghua , Yang Qing , Li Yaqiong , Ding Peikai , Yu Guoxiang , Yao Yiping , Zhao Yueran , Tian Xingsong 
Published: August 2020

Abstract
Background：Lymphogenous metastasis, one of the most common dissemination routes for ovarian carcinoma, predicts a poor prognosis and relates to most cancer-related death. Now there were no effective therapy and control methods for ovarian carcinoma. Hence, it is necessary to build an animal model of lymph node metastasis in ovarian cancer to seek for the tools to find effective treatments. Our purpose of this study was to investigate the tumor cell dissemination of ovarian carcinoma to the gradient lymph nodes of nude mice and its possible mechanism. Methods: The mice models of VEGF-D over-expressed were built and the tumor growth and sentinel lymph nodes were evaluated weekly, while the visible lymph nodes and tumor masses were excised for histological examination using HE examination. Then Evan’s Blue was conducted to observe the unveil lymphatic network. Subsequently, immunohistochemistry was performed to check the expression of relative genes. Meanwhile, microvessel counting was performed within the tumor tissues and measured using computer assisted morphometric analysis.Results: The over-expression of VEGF-D promoted the tumor growth of ovarian carcinoma, facilitated the hyperplasia of tumor lymphatic and increased the intratumoral lymphatic vessel density. Besides, the up-regulation of VEGF-D induced the expression of MMP-2, which might be the underlying mechanism for the lymph metastasis in ovarian cancer. Conclusion: it was a step-by-step progression from the inoculation of cancer cells, to the proliferation of the primary tumors, and then to the lymphatic metastases, in which VEGF-D and MMP-2 played vital roles.
Корреляция уровня витамина D с гормональным состоянием щитовидной железы и титром антител к рецептору ТТГ у пациентов с болезнью Грейвса
Authors: Pankiv V.I. , Yuzvenko T.Yu. , Koval S.M. , Singh K. , Pankiv I.V. , Sehgal Tarun , Lytvinova O.M. 
Published: August 2020

Актуальность. Во многих исследованиях установлена связь дефицита витамина D с аутоиммунными заболеваниями. Доказано, что уровень витамина D у пациентов с ауто­иммунными заболеваниями щитовидной железы, включая болезнь Грейвса, был ниже, чем у пациентов с неаутоиммунными тиреоидными заболеваниями, например токсическим узловым зобом. В то же время в отдельных статьях сообщают об отсутствии такой зависимости между уровнем витамина D и аутоиммунными заболеваниями щитовидной железы. Цель исследования: сравнить уровень витамина D в сыворотке крови у пациентов с болезнью Грейвса и лиц контрольной группы, оценить соотношение содержания витамина D с функциональным состоянием щитовидной железы и титром антител к рецептору тиреотропного гормона (ТТГ). Материалы и методы. Под наблюдением находились 48 пациентов с болезнью Грейвса и 24 здоровых лица контрольной группы. Всем обследованным проводили гормональные исследования, содержащие уровень ТТГ сыворотки, свободного тироксина, свободного трийодтиронина, паратиреоидного гормона, а также определяли уровень ионизированного кальция, 25-гидроксивитамина D (25(OH)D), титр антител к рецептору ТТГ. Результаты. У пациентов с болезнью Грейвса наблюдался достоверно более низкий уровень 25(OH)D (16,3 ± 1,4 нг/мл) по сравнению с показателями контрольной группы (22,8 ± 1,6 нг/мл) (p = 0,024). Уровни ТТГ и титры антител к рецептору ТТГ достоверно отличались между группой лиц с болезнью Грейвса с дефицитом витамина D (25(OH)D < 20 нг/мл) и группой больных с болезнью Грейвса без дефицита витамина D (25(OH)D ≥ 20 нг/мл). Объем щитовидной железы существенно не отличался между этими группами больных. Уровень витамина D в сыворотке крови достоверно взаимосвязан с концентрацией ТТГ и титром антител к рецептору ТТГ у пациентов с болезнью Грейвса. Выводы. Уровень витамина D в сыворотке крови достоверно ниже у пациентов с болезнью Грейвса при сравнении с показателями контрольной группы. У этих пациентов установлена достоверная корреляция между содержанием витамина D и уровнями ТТГ и антител к рецептору ТТГ.
METODE QIRĀ’AH DALAM PEMBELAJARAN KETERAMPILAN RESEPTIF BERBAHASA ARAB UNTUK PENDIDIKAN TINGKAT MENENGAH
Authors: Khoiriyah Hidayatul 
Published: August 2020

This study aims to determine the implementation of the qirā’ah method in learning Arabic receptive skills for secondary education. The method used is a library research method, while data collection is done by examining and exploring several journal articles, books, and several data sources or other information that are considered relevant to the study. The results of this study are that learning using the qirā’ah method is an alternative for teachers in teaching Arabic receptive skills (mahārah al-istimā’ and mahārah al-qirā’ah). In learning listening skills (mahārah al-istimā’) students are able to understand the contents of what has been listened to and reveal again through their language both orally and in writing. As for reading skills learning (mahārah al-qirā’ah) students are able to read Arabic texts fluently, are able to translate and are able to understand it well and fluently.
ANALISIS KUALITAS TES BAHASA ARAB BERBASIS HIGHER ORDER THINKING SKILL (HOTS)
Authors: Rahmi Nur Fauziah Indah , Syihabudin Syihabudin , Sopian Asep 
Published: August 2020

Educational evaluation is an important aspect, because with educational evaluation, it can be known to what extent the educational process has been achieved, it can also determine the next step regarding what is to be done. In the realm of evaluation, analyzing the quality of HOTS-based tests is still rarely to be done as was the case in Lembang MTs Al-Musyawarah. Arabic Language Teachers have not analyzed the quality of Arabic question items in the final examination (UAS). This research aims to determine the quality of hots-based instruments in final examination (UAS) questions of Arabic that are have not yet know. The type of research that used in this research is descriptive research, and 30 people as the sample of data. The results of this research show that the validity of the test be include high, and high reliability, 25 questions are not fit with the criteria for multiple choice writing, the level of difficulty not yet proporsional, distinguishing power enough, and effectiveness of deceivers are enough categories, and all questions include as Lots category with C1 numbers as much as 2 items, 2 items for C2, and C3 as much as 36 items of questions.
PEMAKAIAN USLUB AL-HAKIM DALAM ALQURAN
Authors: Nugraha Inggo 
Published: August 2020

Artikel penelitian ini bertujuan untuk mendeskripsikan bentuk ungkapan Uslub al-hakim dalam Alquran. Uslub al-hakim adalah bentuk pengalihan pembicaraan kepada sesuatu yang lebih penting. Uslûb al-hakîm merupakan seni dalam ilmu balaghah karena memberikan kesan indah pada pembicaraan seseorang. Pembahasan mengenai Uslûb al-hakîm ini kurang diberikan tumpuan khusus oleh para ulama Balaghah juga para penulis kitab yang didalamnya membahas mengenai uslub al-hakim. Sumber data penelitian ini diambil dari Alquran. Objek penelitiannya terfokus pada ayat-ayat uslub al-hakim yang terdapat dalam Alquran. Adapun datanya dihimpun melalui dokumentasi dan format pencatatan. Kemudian datanya dianalisis secara kualitatif. Hasil penelitian menunjukan bahwa terdapat delapan puluh dua ungkapan uslub al-hakim dalam Alquran. Ungkapan uslub al-hakim tersebut dapat diklasifikasikan ke dalam empat bentuk
Korelasi Antara Persepsi Siswa Terhadap Penerapan Model Non Directive Teaching Dengan Motivasi Belajar Bahasa Arab Di SMK Muhammadiyah Prambanan
Authors: Nurlaila Nurlaila 
Published: August 2020

Model Pembelaaran non directive teaching merupakan salah satu model pengajaran personal yang didasarkan pada teori konseling karya Carl Rogers yang menyatakan bahwa hubungan positif antar sesama manusia memudahkan mereka untuk tumbuh. SMK Muhammadiyah Prambanan merupakan sekolah berbasis kejuruan, yang mana mayoritas siswanya merupakan remaja laki-laki. Selain problem linguistik (fonologi, morfologi, sintaksis, dan semantik) yang merupakan problem utama yang dihdapai oleh siswa, di sisi lain berdasarkan background keilmuan diminati siswa adalah keilmuan praktis (empiris) sehingga kecenderungan siswa untuk mempelajari ilmu-ilmu normatik-teoritik seperti bahasa Arab masih sangat minim. Oleh karena itu perlu adanya treatmen dan prilaku khusus untuk meningkatkan motivasi siswa dalam belajar bahasa Arab. Model non directive teaching dengan pendekatan personalnya membangun hubungan positif diharapak dapat diciptakan dengan membangun relasi yang baik antara guru dengan siswa atau siswa dengan siswa lainnya sehingga menciptakan dorongan untuk belajar. Penelitian ini bertujuan untuk mengetahui ada tidaknya korelasi antara persepsi siswa terhadap penerapan model non directive teaching dengan motivasi belajar bahasa Arab siswa. Penelitian ini adalah penelitian deskriptif kuantitatif, dengan subjek penelitian siswa kelas XI SMK Muhammadiyah Prambanan yang diperoleh dengan random sampling. Pengumpulan data menggunakan metode angket, observasi, wawancara dan dokumentasi. Analisis data menggunakan statistik deskriptif dan inferensial melalui uji korelasi sederhana (product moment) dan uji regresi sederhana, yang sebelumnya dilakukan uji normalitas dan uji linieritas. Hasil penelitian menunjukan terdapat hubungan dan pengaruh yang positif signifikan antara persepsi siswa terhadap penerapan model non directive teaching dengan motivasi belajar bahasa Arab siswa.
التأويل النحوي عند ابن جني في (الفَسْر ) شرح ابن جني الكبير على ديوان المتنبي
Authors: Al Adba'iy Abdol Ghaniy Syauqiy Musa , Bin 'Aly Musa Sa'ied Bin Muhammed 
Published: August 2020

تهدف فكرة التأويل النحوي عامة في الفكر النحوي العربي إلى اتساق العلاقة بين النص والقاعدة والتوفيق بين أساليب اللغة والقواعد النحوية، وهذا البحث ( التأويل النحوي عند ابن جني)، في(الفسر ) شرح ابن جني الكبير على ديوان المتنبي، يهدف إلى إظهار جهود ابن جني في التأسيس لظاهرة التأويل في النحو العربي، وبيان مظاهره ، والكشف عن مقاصده ، وقد اشتمل على بعض من مظاهر التأويل النحوي مثل: الحذف والزيادة والتضمين والحمل على المعنى.
Arterial Placement of Central Venous Catheters
Authors: Wierstra Benjamin , Au Selena , Cantle Paul , Rommens Kenton 
Published: August 2020

Arterial misplacement of central venous catheters can often be avoided with the use of real-time ultrasound-guided procedural competency. However, misplacement can still occur and is more likely to occur when the internal jugular vein is located directly above the common carotid injury. The resultant injury to the common carotid artery occurs through the posterior wall of the internal jugular vein. Arterial injury may also occur when the subclavian vein is attempted in a non-ultrasound-guided fashion. Optimal management requires a coordinated evaluation of the catheter misplacement by Interventional Radiology and Vascular Surgery to ensure maximum patient safety during catheter removal. This article reviews the literature around this topic and provides a summary of the best approach to safely remove the misplaced catheter.
Resume
Le mauvais positionnement artériel des cathéters veineux centraux peut souvent être évité grâce à l'utilisation de compétences procédurales guidées par ultrasons en temps réel. Cependant, un mauvais positionnement peut toujours se produire et est plus susceptible de se produire lorsque la veine jugulaire interne est située directement au-dessus de la lésion carotidienne commune. La lésion de l'artère carotide commune qui en résulte se produit à travers la paroi postérieure de la veine jugulaire interne. Une lésion artérielle peut également se produire lorsque la veine sous-clavière n'est pas guidée par un ultrason. Une gestion optimale nécessite une évaluation coordonnée du mauvais positionnement du cathéter par la radiologie interventionnelle et la chirurgie vasculaire afin de garantir une sécurité maximale au patient lors du retrait du cathéter. Cet article passe en revue la littérature sur ce sujet et fournit un résumé de la meilleure approche pour retirer en toute sécurité le cathéter mal placé.
Starting Your Career at an Accounting Firm: The Role of Personality in Explaining Career Starts
Authors: Kerckhofs Linde , Hardies Kris , Vandenhaute Marie-Laure , Ceustermans Stefanie 
Published: August 2020

SYNOPSIS
We investigate whether personality traits affect graduate business students' decisions to start their career (1) in the accounting profession, and (2) at a Big 4 accounting firm. Survey data (n = 348) show that students with lower levels of openness to experience are more likely to seek careers in accounting. Further, students with higher levels of narcissism are more likely to start their careers in a Big 4 firm. Additionally, the effect of narcissism on students' decisions to seek careers at Big 4 firms is fully mediated by their attitudes toward the Big 4. Compared to students who seek careers at non-Big 4 firms, Big 4 career seekers believe that the Big 4 offer higher salaries, better opportunities for training, experience, and networking, more advancement opportunities, better career prospects, more interesting, challenging, and fulfilling work, more friendly colleagues, a better relationship with supervisors, more job security, and higher prestige.
Kombinasi Metode ISOMAP Dan KNN Pada Image Processing Untuk Pengenalan Wajah
Authors: Kosasih Rifki 
Published: August 2020

Wajah manusia memiliki ciri khusus yang dapat membedakan dengan orang lainnya sehingga pengenalan wajah sangat penting dilakukan untuk mengenali seseorang. Ciri khusus pada wajah ini disebut juga dengan fitur. Pada penelitian ini, untuk mendapatkan fitur dilakukan pengenalan pola citra wajah dengan menggunakan metode isomap. Metode isomap merupakan salah satu metode dari manifold learning yang menghasilkan fitur-fitur dengan cara mereduksi dimensi. Citra wajah yang digunakan dalam penelitian ini terdiri dari 6 orang dengan tiap orang memiliki 4 citra wajah dengan ekspresi yang berbeda-beda. Data citra ini dibagi menjadi dua bagian yaitu data latih dan data uji. Selanjutnya data citra tersebut diubah menjadi vektor. Metode isomap digunakan untuk mentransformasikan vektor tersebut menjadi vektor yang mengandung fitur wajah. Setelah fitur wajah diperoleh, selanjutnya dilakukan pengujian pada data uji dengan menggunakan algoritma K Nearest Neighbor (KNN). Algoritma K Nearest Neighbor digunakan untuk pengklasifikasian dengan cara mencari K data latih yang terdekat dengan data uji. Dari hasil klasifikasi diperoleh bahwa tingkat akurasi sebesar 83,33%.
Colchicine for the treatment of cardiovascular diseases: old drug, new targets
Authors: Andreis Alessandro , Imazio Massimo , De Ferrari Gaetano Maria 
Published: August 2020

Well known in past centuries as a herbal remedy for osteoarticular pain and commonly used in the treatment of gout and familial Mediterranean fever, colchicine has an emerging role in the setting of cardiovascular diseases. Its unique properties not only target the key mechanisms of recurrent inflammation underlying pericardial syndromes but also inflammation within atherosclerotic plaques, atrial fibrillation recurrence and adverse ventricular remodelling leading to heart failure.
The effect of colchicine in the treatment of cardiovascular diseases along with essential pharmacology will be discussed, reviewing the most important and recent clinical studies. Colchicine is a valuable, well tolerated and inexpensive drug in the setting of cardiovascular diseases.
Emerging therapy in light-chain and acquired transthyretin-related amyloidosis: an Italian single-centre experience in heart transplantation
Authors: Di Nora Concetta , Sponga Sandro , Ferrara Veronica , Patriarca Francesca , Fanin Renato , Nalli Chiara , Lechiancole Andrea , Vendramin Igor , Livi Ugolino 
Published: August 2020

Aims
The prognosis for patients affected by light-chain cardiac amyloidosis and acquired transthyretin-related (TTR) amyloidosis is poor. Heart transplantation (HTx) could improve prognosis also enabling autologous stem cell transplantation (ASCT) in the first group.

Methods and results
A total of 36 patients affected by systemic amyloidosis have been referred to our centre from 2009 to 2019. Of these, nine had cardiac involvement: seven by light-chain amyloidosis and two by acquired TTR amyloidosis. None died while waiting for HTx. A specific internal protocol useful to select candidates and to monitor the organ involvement after HTx was developed. Median age at diagnosis was 54 years and 66% were male. The most common short-term complication after HTx was renal failure (44%), followed by acute cardiac rejection more than 2R (22%). ASCT was performed in six out of seven light-chain cardiac amyloidosis patients, with a median time of 6 months after HTx. Two patients affected by light-chain cardiac amyloidosis died due to amyloidosis relapse: one before undergoing ASCT. After a median follow-up of 31 (7–124) months, 1- and 5-year survival was 88 and 66% in the cardiac light-chain amyloidosis group. Conversely, 1- and 5-year survival was 100% in the acquired TTR amyloidosis group.

Conclusion
HTx may represent a valuable option in carefully selected patients. ASCT after HTx is an effective treatment that could decrease amyloidosis relapse in light-chain cardiac amyloidosis patients. A multidisciplinary approach is mandatory to select the best candidates and to obtain the most effective results with a specific surveillance follow-up protocol.