bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Determinants Of Clinical Phenotype In Hypertrophic Cardiomyopathy&nbsp;
Authors: Velicki Lazar , Jakovljevic Djordje G , Preveden Andrej , Golubovic Miodrag , Bjelobrk Marija , Ilic Aleksandra , Stojsic Snezana , Barlocco Fausto , Tafelmeier Maria , Okwose Nduka , Tesic Milorad , Brennan Paul , Ristic Arsen , Popovic Dejana , MacGowan Guy A , Filipovic Nenad , Maier Lars S. , Olivotto Iacopo 
Published: November 2020

Abstract
Background: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease that affects approximately one in 500 people. HCM is a recognized genetic disorder most often caused by mutations involving myosin-binding protein C (MYBPC3) and β-myosin heavy chain (MYH7) which are responsible for approximately three-quarters of the identified mutations.Methods: As a part of the international multidisciplinary SILICOFCM project (www.silicofcm.eu) the present study evaluated the association between underlying genetic mutations and clinical phenotype in patients with HCM. Only patients with confirmed single pathogenic mutations in either MYBPC3 or MYH7 genes were included in the study and divided into two groups accordingly. The MYBPC3 group was comprised of 48 patients (76%), while the MYH7 group included 15 patients (24%). Each patient underwent clinical examination and echocardiography.Results: The most prevalent symptom in patients with MYBPC3 was dyspnea (44%), whereas in patients with MYH7 it was palpitations (33%). The MYBPC3 group had a significantly higher number of patients with a positive family history of HCM (46% vs. 7%; p=0.014). There was a numerically higher prevalence of atrial fibrillation in the MYH7 group (60% vs. 35%, p=0.085). Laboratory analyses revealed normal levels of creatinine (85.5±18.3 vs. 81.3±16.4 µmol/l; p=0.487) and blood urea nitrogen (10.2±15.6 vs. 6.9±3.9 mmol/l; p=0.472) which were similar in both groups. The systolic anterior motion presence was significantly more frequent in patients caring MYH7 mutation (33% vs. 10%; p=0.025), as well as mitral leaflet abnormalities (40% vs. 19%; p=0.039). Calcifications of mitral annulus were registered only in MYH7 patients (20% vs. 0%; p=0.001). The difference in diastolic function, i.e. E/e’ ratio between the two groups was also noted (MYBPC3 8.8±3.3, MYH7 13.9±6.9, p=0.079).Conclusions: Major findings of the present study corroborate the notion that MYH7 gene mutation patients are presented with more pronounced disease severity than those with MYBPC3.
Cost-effectiveness of the Adaptive Implementation of Effective Programs Trial (ADEPT): approaches to adopting implementation strategies
Authors: Eisman Andria B , Hutton David , Prosser Lisa , Smith Shawna , Kilbourne Amy 
Published: November 2020

Abstract
Background: Theory-based methods to support the uptake of evidence-based practices (EBPs) are critical to improving mental health outcomes. Implementation strategy costs can be substantial, and few have been rigorously evaluated. The purpose of this study is to conduct a cost-effectiveness analysis to identify the most cost-effective approach to deploying implementation strategies to enhance the uptake of Life Goals, a mental health EBP. Methods: We used data from a previously conducted randomized trial to compare the cost-effectiveness of Replicating Effective Programs (REP) combined with external and/or internal facilitation among sites non-responsive to REP. REP is a low-level strategy that includes EBP packaging, training, and technical assistance. External facilitation (EF) involves external expert support, and internal facilitation (IF) augments EF with protected time for internal staff to support EBP implementation. We developed a decision tree to assess 1-year costs and outcomes for four implementation strategies: 1) REP only, 2) REP+EF 3) REP+EF add IF if needed, 4) REP+EF/IF. The analysis used a 1-year time horizon and assumed a health payer perspective. Our outcome was quality-adjusted life years (QALYs). The economic outcome was the incremental cost-effectiveness ratio (ICER). We conducted deterministic and probabilistic sensitivity analysis (PSA). Results: Our results indicate that REP+EF add IF is the most cost-effective option with an ICER of $593/QALY. The REP+EF/IF and REP+EF only conditions are dominated (i.e., more expensive and less effective than comparators). One-way sensitivity analyses indicate that results are sensitive to utilities for REP+EF and REP+EF add IF. The PSA results indicate that REP+EF, add IF is the optimal strategy in 30% of iterations at the threshold of $100,000/QALY. Conclusions: Our results suggest that the most cost-effective implementation support begins with a less intensive, less costly strategy initially and increases as needed to enhance EBP uptake. Using this approach, implementation support resources can be judiciously allocated to those clinics that would most benefit. Our results were not robust to changes in the utility measure. Research is needed that incorporates robust and relevant utilities in implementation studies to determine the most cost-effective strategies. This study advances economic evaluation of implementation by assessing costs and utilities across multiple implementation strategy combinations.
Impact of autologous platelet rich plasma use on postoperative acute kidney injury in type A acute aortic dissection repair: A retrospective cohort analysis
Authors: Tong Jiaqi , Cao Liang , Liu Liwei , Jin Mu 
Published: November 2020

Abstract
Background Perioperative coagulopathy and blood transfusion are common in patients undergoing Stanford type A acute aortic dissection (AAD) repair. The autologous platelet-rich plasmapheresis (aPRP) technique is a blood conservation approach to reduce blood transfusions and morbidity in patients at high risk of bleeding. The purpose of this study was to analyze the effect of aPRP on outcomes, especially in postoperative acute kidney injury (post-AKI), in patients undergoing AAD surgery.Methods Six hundred sixty patients were divided into aPRP and non-aPRP groups according to aPRP use. The primary endpoint was the difference in the incidence of post-AKI between two groups. The secondary endpoints were risk factors for post-AKI and to assess clinical outcomes. The risk factors associated with post-AKI were calculated, and all outcomes were adjusted by propensity-score matching analysis.Results A total of 272 patients (41.2%) received aPRP, whereas 388 were in the non-aPRP group. Compared to non-aPRP group, the occurrence of post-AKI increased by 14.1% (p=0.002) and 11.1% (p=0.010) with and without propensity adjustment in the aPRP group, respectively. The aPRP group required fewer intraoperative transfusions (p<0.05) and shortened the duration of mechanical ventilation (p<0.05) than those in the non-aPRP group. Multiple regression analyses showed that aPRP (odds ratio: 1.729, 95% confidence interval: 1.225–2.440; p<0.001) was one of the independent risk factors for post-AKI. Conclusions The use of aPRP significantly reduced intraoperative blood transfusions and decreased postoperative mortality-adjusted mechanical ventilation. However, aPRP use was independently associated with an increased hazard of post-AKI after adjusting for confounding factors.
Power Transformer Fault Diagnosis System Based on Internet of Things
Authors: Wang Guoshi , Liu Ying , Chen Xiaowen , Yan Qing , Sui Haibin , Ma Chao , Zhang Junfei 
Published: November 2020

Abstract
Transformer is the most important equipment in the power system. The research and development of fault diagnosis technology for Internet of things equipment can effectively detect the operation status of equipment and eliminate hidden faults in time, which is conducive to reducing the incidence of accidents and improving people's life safety index. Objective: To explore the utility of Internet of things in power transformer fault diagnosis system. Methods: A total of 30 groups of transformer fault samples were selected, and 10 groups were randomly selected for network training, and the rest samples were used for testing. The matter-element extension mathematical model of power transformer fault diagnosis was established, and the correlation function was improved according to the characteristics of three ratio method. Each group of power transformer was diagnosed for four months continuously, and the monitoring data and diagnosis were recorded and analyzed result. GPRS communication network is used to complete the communication between data acquisition terminal and monitoring terminal. According to the parameters of the database, the working state of the equipment is set, and various sensors are controlled by the instrument driver module to complete the diagnosis of transformer fault system. Results: The detection success rate of the power transformer fault diagnosis system model established in this paper is as high as 95.6%, the training error is less than 0.000l, and it can correctly identify the fault types of the non training samples. It can be seen that the technical support of the Internet of things is helpful to the upgrading and maintenance of the power transformer fault diagnosis system.
Agricultural subsidies and global greenhouse gas emissions
Authors: Vos Rob , Debucquet David Laborde , Martin William , Pineiro Valeria , Mamun Abdullah 
Published: November 2020

Abstract
Agricultural production is both strongly affected by climate change and a major contributor to climate change, with agriculture and land use change accounting for around a quarter of total global emissions of greenhouse gases. Agricultural production benefits from substantial government support, costing around US$600 billion per year worldwide. These subsidies clearly affect greenhouse gas emissions by influencing the composition and location of output, and production practices, but no rigorous quantification of these impacts have been available to date. This article fills this void. Overall, we find small impacts of agricultural support programs on output and hence on emissions. Abolishing support altogether thus would do little to reduce global emissions from agriculture. In fact, paradoxically, it could even increase emissions. A repurposing of support towards incentives for more resource-efficient and climate-smart forms of production needs to be considered if this support is to contribute to climate change mitigation, adaptation and food security.
Relapses of urogenital tuberculosis
Authors: Kulchavenya E. V. , Shevchenko S. Yu. , Kholtobin D. P. , Baranchukova A. A. 
Published: November 2020

The objective of the study: to characterize the cases of tuberculosis relapses with lesion in urogenital organs.Subjects and methods. Out of 140 case histories of patients with urogenital tuberculosis (UGTB; tuberculosis of the urinary and male reproductive system), registered for follow-up by the phthisiourologist, all files of patients with tuberculosis relapses were picked up, totally, there were 13 of them.Results. Men prevailed among cases of relapses (61.5%). Patients at the age of 30-50 years old made 46.1%, and 53.9% were 51 years old and above. In the first episode of tuberculosis, lesions of the genitourinary system were observed in 53.9% of patients, bacterial excretion was found in 38.5%. On the average, the relapse developed in 9.1 years after successful cure of the first episode of tuberculosis: after respiratory tuberculosis – in 5.6 years and after UGTB – in 12.3 years. In 3 (23.1%) patients with relapse, mycobacteriuria was documented, in 1 of them, drug resistance (to streptomycin and isoniazid) was detected. In general, in the relapse of tuberculosis with urogenital lesions, the kidneys were most often (69.2%) affected. The treatment of relapse was effective in 12 out of 13 patients. During chemotherapy of tuberculosis, 3 (23.1%) patients developed toxic and allergic reactions that required treatment interruption or cancellation of the drug.
Legacy Effect of Antioxidant N-acetylcysteine in Cellular Senescence of Diet-induced Obesity Mice
Authors: Tsao Cheng-Feng , Chang Yen-Hsiang , Shen Feng-Chih , Su Yu-Jih , Lin Hung-Yu , Chang Chia-Shiang , Lin Ching-Yi , Lian Wei-Shiung , Chuang Jiin-Haur , Lin Tsu-Kung , Liou Chia-Wei , Wang Pei-Wen , Weng Shao-Wen 
Published: November 2020

Background:
Cellular senescence is a state of stable growth arrest triggered
by mitogenic and metabolic stressors. Ageing and a high-fat diet (HFD) are proven
inducers of senescence in various organs, presenting a challenge for ageing populations
worldwide. Our previous study demonstrated that ROS scavenger N-acetylcysteine
(NAC) can improve insulin resistance (IR) and chronic inflammation in diet-induced
obesity mice, an effect better achieved through early intervention. We, herein,
investigate whether NAC can improve cellular senescence in a diet-induced obesity
mouse model, and whether a legacy effect is presented with early intervention.

Materials and Methods:
For a twelve-month treatment course, all C57B/L6 mice were
fed a chow diet (CD), high-fat high-sucrose diet (HFD), CD+NAC1-12 (NAC intervention
1st-12th month), HFD+NAC1-12, and HFD+NAC1-6 (NAC intervention 1st-6th month).
Staticalanalysis was used to analyze the different markers of cellular senescence and
inflammation.

Results:
Throughout the study, the HFD group exhibited significantly increased body
weight (BW) and body fat, markers of senescence, decreased motor activity (MA) and
impaired glucose tolerance. Compared to the HFD group, the HFD+NAC1-12 group
exhibited increased MA, decreased BW and body fat, improved glucose tolerance, and
decreased senescence markers.The HFD+NAC1-6 group showed similar effects to the
HFD+NAC1-12 group, despite discontinuing NAC for 6 months. Our study showed that NAC
significantly increased MA in both HFD+NAC1-12 and HFD+NAC1-6 groups, and improved
HFD-induced mitochondrial and intracellular ROS expression, DNA and protein oxidative
damage, and adipose tissue inflammation.

Conclusion:
Legacy effect was indeed presented in HFD-induced cellular senescence
with NAC intervention, with possible mechanisms being persistently increased motor
activity and anti-oxidative stress effects.
A ação federal sobre o ensino secundário e superior até 1930
Authors: Bastos Silva Geraldo 
Published: November 2020

Podemos dizer que no debate entre centralizadores e descentralizadores,que se vem travando a propósito da lei de bases e diretrizes da educaçãonacional, prevista pela Constituição de 1946, não se focalizou devidamentea experiência brasileira de ensino no período 1899-1930, ao menos no quese refere ao ensino secundário e ao superior. O parecer do Deputado G u s t a v oC a p a n e m a , contrário ao ante-projeto elaborado pela comissão nomeada peloMinistro Mariani, não só tocou muito de leve no assunto, como, também, noesforço de afirmar uma tendência centralizadora homogênea e constante, doAto Adicional à atualidade, simplificou indevidamente a situação vigenteno período referido. Disse o Sr. Gustavo Capanema: “Tão convincente foi aexperiência monárquica, tão avisados estavam os espíritos com relação aosmaíes de uma grande descentralização no ensino, que a federação, paradoxalmente,veio centralizar a organização educacional do Brasil. Compare-se oart° 10 do Ato Adicional de 1834 com o art° 35 da Constituição de 189 1. ese verá que, por uma forma expressa ou subtendida, o segundo documento,em matéria de ensino, dá amplitude muito maior às atribuições nacionais.Sob o regime da Constituição de 1891, foi-se processando a centralização daorganização pedagógica do país numa convergência nacional cada vez maispronunciada. A legislação do ensino superior não deixou de pertencer à competênciada União. O ensino secundário tornou-se assunto de regulamentaçãor.xclusivamente federal”.
Ecologia Administrativa
Authors: De Magalhães Celso 
Published: November 2020

Ecologia é a ciência que determina a influência do local sôbre os organismos que nêle se encontram. Todos sabem que o trigo, por exemplo, não dá em qualquer parte, como sabem que o elefante não vive em qualquer lugar. A planta e o animal, quando» mudam de habitat, sofrem transformações por vêzes muito grandes. Para qtie isso não suceda, e possam algumas espécies sobreviver, necessário se torna tratá-las de forma especial, que a Ecologia orienta.
Detection of Hate Speech in COVID-19–Related Tweets in the Arab Region: Deep Learning and Topic Modeling Approach
Authors: Alshalan Raghad , Al-Khalifa Hend , Alsaeed Duaa , Al-Baity Heyam , Alshalan Shahad 
Published: November 2020

Background
The massive scale of social media platforms requires an automatic solution for detecting hate speech. These automatic solutions will help reduce the need for manual analysis of content. Most previous literature has cast the hate speech detection problem as a supervised text classification task using classical machine learning methods or, more recently, deep learning methods. However, work investigating this problem in Arabic cyberspace is still limited compared to the published work on English text.

Objective
This study aims to identify hate speech related to the COVID-19 pandemic posted by Twitter users in the Arab region and to discover the main issues discussed in tweets containing hate speech.

Methods
We used the ArCOV-19 dataset, an ongoing collection of Arabic tweets related to COVID-19, starting from January 27, 2020. Tweets were analyzed for hate speech using a pretrained convolutional neural network (CNN) model; each tweet was given a score between 0 and 1, with 1 being the most hateful text. We also used nonnegative matrix factorization to discover the main issues and topics discussed in hate tweets.

Results
The analysis of hate speech in Twitter data in the Arab region identified that the number of non–hate tweets greatly exceeded the number of hate tweets, where the percentage of hate tweets among COVID-19 related tweets was 3.2% (11,743/547,554). The analysis also revealed that the majority of hate tweets (8385/11,743, 71.4%) contained a low level of hate based on the score provided by the CNN. This study identified Saudi Arabia as the Arab country from which the most COVID-19 hate tweets originated during the pandemic. Furthermore, we showed that the largest number of hate tweets appeared during the time period of March 1-30, 2020, representing 51.9% of all hate tweets (6095/11,743). Contrary to what was anticipated, in the Arab region, it was found that the spread of COVID-19–related hate speech on Twitter was weakly related with the dissemination of the pandemic based on the Pearson correlation coefficient (r=0.1982, P=.50). The study also identified the commonly discussed topics in hate tweets during the pandemic. Analysis of the 7 extracted topics showed that 6 of the 7 identified topics were related to hate speech against China and Iran. Arab users also discussed topics related to political conflicts in the Arab region during the COVID-19 pandemic.

Conclusions
The COVID-19 pandemic poses serious public health challenges to nations worldwide. During the COVID-19 pandemic, frequent use of social media can contribute to the spread of hate speech. Hate speech on the web can have a negative impact on society, and hate speech may have a direct correlation with real hate crimes, which increases the threat associated with being targeted by hate speech and abusive language. This study is the first to analyze hate speech in the context of Arabic COVID-19–related tweets in the Arab region.
A Moderated Mediation Analysis of Condom Negotiation and Sexual Orientation on the Relationship Between Sexual Coercion and Condom Use in Chinese Young Women: Cross-Sectional Study
Authors: Zhang Wen , Choi Edmond Pui Hang , Fong Daniel Yee-Tak , Wong Janet Yuen-Ha 
Published: November 2020

Background
The high prevalence of sexual coercion against young women has become a significant public health issue in China and other regions around the world. Young women are also especially vulnerable to engage in inconsistent condom use because of low sexual control. Although the relationship between sexual coercion and condom use has been widely demonstrated, the mechanism of this relationship is still unclear.

Objective
The objective of this study was to test condom negotiation as a mediator of the relationship between sexual coercion and condom use in young Chinese women and to investigate whether sexual orientation is a moderator.

Methods
Data were collected using web-based questionnaires and a total of 402 young Chinese women were included in the analysis. Sexual coercion was measured using a subscale of the Revised Conflict Tactics Scales and condom negotiation was measured using a subscale of the UCLA Multidimensional Condom Attitudes Scale. Sexual orientation was assessed using an item adopted from a previous study and condom use was calculated by the total number of times condoms were used divided by the total number of times sexual intercourse was engaged in during the past 3 months. Moderated mediation analyses were conducted with sexual coercion as the independent variable, condom use consistency as the dependent variable, condom negotiation as the mediator variable, and sexual orientation as a moderator.

Results
The moderated mediation analysis indicated that the relationship between sexual coercion and condom use was significantly mediated by condom negotiation and moderated by sexual orientation. The indirect effect of condom negotiation was significant in heterosexual women (indirect effect: –0.80, 95% boot CI –1.67 to –0.36) but not in sexual minority women (indirect effect: –0.33, 95% boot CI –0.86 to 0.31).

Conclusions
The results showed that sexual orientation meaningfully affects the relationship between sexual coercion and condom negotiation. The difference in the mechanism of the relation between sexual coercion and sexual behaviors in heterosexual and sexual minority women should be considered for future research and interventions aimed at mitigating the adverse effects of sexual coercion.