bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning–Based Interpretation and Visualization of Nonlinear Interactions in Prostate Cancer Survival
Authors: Li Richard , Shinde Ashwin , Liu An , Glaser Scott , Lyou Yung , Yuh Bertram , Wong Jeffrey , Amini Arya 
Published: July 2020

PURPOSEShapley additive explanation (SHAP) values represent a unified approach to interpreting predictions made by complex machine learning (ML) models, with superior consistency and accuracy compared with prior methods. We describe a novel application of SHAP values to the prediction of mortality risk in prostate cancer.METHODSPatients with nonmetastatic, node-negative prostate cancer, diagnosed between 2004 and 2015, were identified using the National Cancer Database. Model features were specified a priori: age, prostate-specific antigen (PSA), Gleason score, percent positive cores (PPC), comorbidity score, and clinical T stage. We trained a gradient-boosted tree model and applied SHAP values to model predictions. Open-source libraries in Python 3.7 were used for all analyses.RESULTSWe identified 372,808 patients meeting the inclusion criteria. When analyzing the interaction between PSA and Gleason score, we demonstrated consistency with the literature using the example of low-PSA, high-Gleason prostate cancer, recently identified as a unique entity with a poor prognosis. When analyzing the PPC-Gleason score interaction, we identified a novel finding of stronger interaction effects in patients with Gleason ≥ 8 disease compared with Gleason 6-7 disease, particularly with PPC ≥ 50%. Subsequent confirmatory linear analyses supported this finding: 5-year overall survival in Gleason ≥ 8 patients was 87.7% with PPC < 50% versus 77.2% with PPC ≥ 50% ( P < .001), compared with 89.1% versus 86.0% in Gleason 7 patients ( P < .001), with a significant interaction term between PPC ≥ 50% and Gleason ≥ 8 ( P < .001).CONCLUSIONWe describe a novel application of SHAP values for modeling and visualizing nonlinear interaction effects in prostate cancer. This ML-based approach is a promising technique with the potential to meaningfully improve risk stratification and staging systems.
Improving Quality of Cancer Care by Participating in Quality Oncology Practice Initiative Certification Program
Authors: Jazieh Abdul Rahman , Abdelhafiez Nafisa , Al Mutairi Nashmia , Hashem Ahmed , Alkaiyat Mohammad , Al Shami Mona , Jahanzeb Mohammad 
Published: July 2020

PURPOSE ASCO developed the Quality Oncology Practice Initiative (QOPI) to ensure patient safety in oncology outpatient services. We evaluated the impact of participation in QOPI certification on patient care at our institution. METHODS To participate in QOPI, we created a multidisciplinary team, and we chose the required modules and began QOPI participation per program requirement. In the initial round, we scored lower than the required score of 75% to be eligible for QOPI certification. We then implemented multiple measures and interventions, and we conducted multiple Plan, Do, Study, Act cycles (PSDA) cycles to achieve our goal. RESULTS Our score in the initial round was 68%; in the second round, our score remained low at 65%; in the third round, we exceeded the target score by achieving 93%. We completed the certification process with a site visit. In October 2018, we became the first QOPI-certified center in the Middle East and Asia. CONCLUSION We learned many lessons during our journey toward QOPI certification. Essential elements of success included timely assembly of the right multidisciplinary team and clear communication between team members within the institution and with the ASCO QOPI team.
Comparative Phonorhetorical Analyses of Speeches in the Zuo Commentary and the Discourses of the States
Authors: Tharsen Jeffrey R. 
Published: July 2020

Abstract
Research methods employing large-scale databases of digital texts and digital lexica can assist in the detection of the ways phonetic patterns worked in concert with semantic and syntactic structures in premodern Chinese narrative texts. When applied to the speeches by eminent ministers preserved in the Zuo Commentary to the Spring and Autumn Annals and the Discourses of the States, close examinations of the tripartite framework of sound, meaning, and structure allow a deeper understanding of the phonorhetorical techniques employed by their composers (and/or transmitters), emphasizing key terms and imparting subtle feelings of grandeur and harmony. In comparative context, analyses of stylistic elements at scale provide insights into the rhetorical choices made by different authors in formative periods of Chinese literature, choices that informed and influenced future writers and scholars for millennia thereafter.
Identities and Literary Culture in Qing China: Manchu Emperors as Chinese Poets, Readers, and Publishers
Authors: Chow Kai-Wing 
Published: July 2020

Abstract
The Qianlong emperor bequeathed the largest number of Chinese poems of any emperor, and perhaps of any poet, in the history of imperial China. But how do we make sense of the fact that Qianlong had been adamant in maintaining and preserving what he considered the essence of Manchu culture: the Manchu language and hunting skills? This articles argues that, despite deliberate staging through various fashions of his image as the ruler of a multiethnic empire, Qianlong failed in sending his message to his diverse subjects because, truly enthralled by Chinese poetry, he could not restrain himself from writing poetry in Chinese. In light of the theory of multiple identities and acculturation of John Berry, it is reasonable to argue that Qianlong, despite his unambiguous identification with the Manchus as the conquering ethnic group, in tortuous ways had come to embrace the identity of a Chinese poet of the host society, in which the technologies of culture to a large degree overdetermine the form of identities and how they can be articulated, internalized, embodied, and staged.
Phospholipids containing ether-bound hydrocarbon-chains are essential for efficient phagocytosis and neutral lipids of the ester-type perturb development in Dictyostelium
Authors: Kappelt Frederik , Du Ma Xiaoli , Abou Hasna Bassam , Kornke Jessica M. , Maniak Markus 
Published: July 2020

ABSTRACT
Lipids are the building blocks for cellular membranes; they provide signalling molecules for membrane dynamics and serve as energy stores. One path of their synthesis is initiated by glycerol-3-phosphate acyltransferase (GPAT), which in Dictyostelium resides on the endoplasmic reticulum. When an excess of fatty acids is present, it redistributes to storage organelles, the lipid droplets. Mutants, where the GPAT was eliminated by homologous recombination, produce fewer lipid droplets and are almost devoid of triacylglycerols (TAG), rendering them more resistant to cell death and cell loss in the developmental stages preceding fruiting body formation. The enzyme most closely related to GPAT is called FARAT, because it combines a fatty acyl-reductase (FAR) and an acyltransferase (AT) domain in its sequence. The protein is confined to the lumen of the peroxisome, where it transfers a fatty acid to dihydroxyacetone-phosphate initiating the synthesis of ether lipids, later completed at the endoplasmic reticulum. A mutant lacking FARAT produces lipid droplets that are devoid of the storage lipid monoalkyl-diacyl-glycerol (MDG), but the efficiency of spore formation in the developmental cycle is largely unaltered. Instead, these mutants are strongly impaired in phagocytosis of yeast particles, which is attributed to reduced synthesis of membrane phospholipids containing ether-linked chains.
Regulators of H3K4 methylation mutated in neurodevelopmental disorders control axon guidance in Caenorhabditis elegans
Authors: Abay-Nørgaard Steffen , Attianese Benedetta , Boreggio Laura , Salcini Anna Elisabetta 
Published: July 2020

ABSTRACT
Post-translational histone modifications regulate chromatin compaction and gene expression to control many aspects of development. Mutations in genes encoding regulators of H3K4 methylation are causally associated with neurodevelopmental disorders characterized by intellectual disability and deficits in motor functions. However, it remains unclear how H3K4 methylation influences nervous system development and contributes to the aetiology of disease. Here, we show that the catalytic activity of set-2, the Caenorhabditis elegans homologue of the H3K4 methyltransferase KMT2F/G (SETD1A/B) genes, controls embryonic transcription of neuronal genes and is required for establishing proper axon guidance, and for neuronal functions related to locomotion and learning. Moreover, we uncover a striking correlation between components of the H3K4 regulatory machinery mutated in neurodevelopmental disorders and the process of axon guidance in C. elegans. Thus, our study supports an epigenetic-based model for the aetiology of neurodevelopmental disorders, based on an aberrant axon guidance process originating from deregulated H3K4 methylation.
Does the phaco TIp position during clear corneal Phacoemulsification Surgery adversely affect corneal endothelium? TIPS study protocol for a randomised, triple-masked, parallel-group trial of bevel-up versus bevel-down phacoemulsification
Authors: Kaup Soujanya , Shivalli Siddharudha , Ajjinicanda Ganapathi Chinnappa , Arunachalam Cynthia , Buchan John , Kumar Pandey Suresh , Prasad Kudlu Krishna 
Published: July 2020

Introduction: Globally, at least 30 million cataract surgeries are required annually to prevent cataract-related blindness. Corneal endothelial decompensation is one of the most common causes of poor visual outcome following cataract surgery, particularly in those with predisposing factors. The increasing ageing population and reduced visual impairment threshold for cataract surgery have resulted in rising cataract surgical rates and hence, an increase in corneal endothelial decompensation is expected. The role of phaco tip position on corneal endothelial damage is ambiguous. Previous studies have reported contradictory results and were also underpowered to detect a significant difference due to small sample sizes. With no consensus regarding the most cornea-friendly phaco tip position (bevel-up versus bevel-down) during phacoemulsification, we propose a randomised clinical trial with a robust design using direct chop phaco-technique. Objective: To compare the effect of phaco tip position (bevel-up vs. bevel-down) on corneal endothelial cell count during phacoemulsification. Methods: A randomised, multicentre, parallel-group, triple-masked (participant, outcome assessor, and statistician) trial with 1:1 allocation ratio is proposed. By adopting stratified randomisation (according to cataract grade), we will randomly allocate 480 patients aged >18 years with immature cataract into bevel-up and bevel-down groups at two centres. History of significant ocular trauma, previous intraocular surgery, shallow anterior chamber, low endothelial cell count, pseudoexfoliation syndrome, intraocular inflammation, and corneal endothelial dystrophy are the key exclusion criteria. The primary outcome is postoperative endothelial cell count at one month. Secondary outcomes are central corneal thickness on postoperative days 1, 15, and 30, and intraoperative complications. Trial registration: Clinical Trial Registry of India CTRI/2019/02/017464 (05/02/2019).
Wideband and polarization-insensitive metamaterial absorber with loading lumped resistors
Authors: Xiong Han , Bin Long Tian , Shi Ting , Xuan Jiang Bing , Tao Zhang Jun 
Published: July 2020

IWe have designed, simulated, and experimentally tested a broadband metamaterial absorber loaded with lumped resistors in the microwave range. Compared with an electric resonator structure absorber, the composite absorber loaded with lumped resistors has stronger absorptivity over an extremely extended bandwidth. The simulated results show that an effective absorption bandwidth covers from 7.12 to 8.61 GHz with the absorption rate more than 90% under normal incidence. For oblique incidence, the proposed absorber displays an absorption rate above 90% from 7.55 to 8.61 GHz when the incident angle is below 35° for the transverse electric polarization. About the transverse magnetic polarization, the absorber displays larger than 90% absorptance from 7.24 to 8.61 GHz when the incident angle is below 70°. During the entire design process, the absorber structure is fabricated and measured. The measured results show that the absorptivity is above 90% in the frequency range of 6.78–7.65 GHz and 8.20–9.31 GHz under normal incidence. Furthermore, the absorption mechanism and absorption properties are further researched.
Intra-node high-performance computing network architecture with nanosecond-scale photonic switches [Invited]
Authors: Maniotis Pavlos , Dupuis Nicolas , Schares Laurent , Kuchta Daniel M. , Taubenblatt Marc A. , Lee Benjamin G. 
Published: July 2020

We propose a single-stage network architecture for intra-node connectivity that makes use of nanosecond-scale photonic switches. Although buffering at the switch points is of vital importance for complex multistage networks, this is not the case for smaller-scale single-stage networks where the end nodes are located only one hop apart. By limiting the buffering to the end points, the proposed architecture manages to minimize the required electro-optic and opto-electronic conversions, leading in this way to both low end-to-end latency and better energy efficiency. Combining these advantages with nanosecond-scale switching times can allow for high-throughput operation, even for frequent switch reconfigurations. The performance of the proposed architecture is evaluated via discrete-event simulations for a wide range of synthetic-traffic cases. The simulation results show that high-throughput operation of

≥

90

%

can be achieved even for small message sizes, i.e., 32 KB for all-to-all communication and 2 KB for uniform random traffic, at a data rate of 400 Gb/s and a switch reconfiguration time of

≤

72

n
s

. Moreover, if 100 ns reconfiguration times are achievable as opposed to 150 ns, then for the all-to-all traffic case a 16% and 28% reduction in completion time can be achieved for message sizes of 8 KB and 1 KB, respectively. In a forthcoming era of optically interfaced processors and accelerators, nanosecond-scale photonic switches appear as a highly promising solution for keeping up with the intra-node bandwidth scaling due to their high-bandwidth, low-latency, and fast-switching capabilities.
Electro-optically tunable laser with ultra-low tuning power dissipation and nanosecond-order wavelength switching for coherent networks
Authors: Ueda Yuta , Shindo Takahiko , Kanazawa Shigeru , Fujiwara Naoki , Ishikawa Mitsuteru 
Published: July 2020

The huge amount of data traffic behind the rapid growth of cloud computing is putting pressure on the operation of mobile fronthauls and data center networks so there is a need to improve their power consumption and latency. We developed an electro-optically tunable laser diode employing a tunable filter that is practically tuned even with small refractive index change of the electro-optic effect. The laser shows a small tuning power dissipation of less than 10 mW for a practical tuning range of over 35 nm with a linewidth of about 350 kHz. We also achieved high-speed optical switching of less than 50 ns for 100 Gb/s coherent signals. In addition to its application in optical communications, the electro-optically tunable laser diode is also beneficial to laser sensing applications because its higher tuning speed increases the time resolution of the sensing system. Furthermore, a narrow linewidth, conventionally difficult to reconcile with high-speed tuning, can also enable a longer sensing distance and/or a higher signal-to-noise ratio when using coherent detection. Our result shows that we can use the electro-optic effect to overcome the limitations of conventional tunable laser diodes and drastically change optical communications and laser sensing systems.
Alcoolismo Feminino: Perfil das Publicações Científicas Brasileira sobre a Temática / Female Alcoholism: Profile of Brazilian Scientific Publications on the Subject
Authors: Lopes Juliana Custódio , Silva Eliane Moura da , Olinda Antônia Gomes de , Fonseca Wanaline , Ferreira Rosana Alves da Silva 
Published: July 2020

O objetivo do presente estudo foi fum levantamento das publicações científicas brasileiras sobre o alcoolismo feminino. Materiais e Métodos: estudo qualitativo e descritivo, desenvolvido por meio de uma revisão integrativa da literatura (RIL) nos anos de 2008 a 2018, que aborde sobre a temática do alcoolismo feminino. Resultados: a partir do descritor “Alcoolismo”, foram encontrados 1402 resultados, sendo 36 artigos na base de dados SCIELO, 1265 no LILACS e 101 na base de dados BDENF. Discussão: 90 referências foram selecionadas. Somente 21 referências abordavam sobre o tema em questão, 03 produções não tinham relação com a mulher alcoólatra, 03 estavam duplicados e 02 não possuíam afinidade com o tema. A amostra final foi de 13 produções. Tais evidências demonstram poucas referências sobre a temática nas bases de dados atuais. Conclusão: Diante desse contexto é notória a escassez de conhecimento sobre o alcoolismo feminino, principalmente pela transformação progressiva do papel da mulher na sociedade moderna.
Metodologias Aplicadas no Ensino de Química / Methodologies Applied In Teaching Chemistry
Authors: Cardoso Maria Regina De Souza , Miguel Joelson Rodrigues 
Published: July 2020

O presente trabalho pretende uma discussão sobre a realidade sobre as práticas pedagógicas assistidas no âmbito educativo do ensino da química, que possibilite uma reflexão ativa da atuação docente. O objetivo geral foi refletir sobre as práticas metodológicas necessárias e vigentes para o estudo da química. A metodologia consistiu em revisão integrativa, com aportes teóricos de autores como: Tardif (2014), Moran (2015), Berbel (2011), e chassot (1990), dentre outros. Os resultados levaram a crer que o uso de metodologias alternativas tendem a minimizar as diferenças e diversidades entre os alunos, por conta do envolvimento que proporciona o trabalho coletivo, e também pela motivação que proporciona os momentos de interação e aprendizagem.
Notas sobre as Políticas Públicas de Refugiados LGBTI’s no Brasil: Uma Revisão de Literatura / Notes on Public Policies for LGBTI’s Refugees in Brazil: A Literature Review
Authors: Sampaio Bruno Moraes Arraes , Ifadireó Miguel Melo , Albuquerque Filho José Antônio De 
Published: July 2020

O presente artigo tem como função apresentar a questão do refugiado, com a descrição de políticas públicas do Brasil e em alguns lugares do mundo, como também, observar como se dá o processo de solicitação do refúgio, analisando as instituições como o CONARE. No primeiro capítulo busco trazer as considerações acerca do refugiado, como também definições e contexto histórico. O segundo capítulo traz as razões do refúgio, razões essas objetivas e subjetivas a partir do Manual de Procedimentos e Critérios a Aplicar para Determinar a Condição de Refugiado, em que mostra alguns tipos de violência sofridos pelo migrante e como a condição de refugiado pode ser determinada. O terceiro e último capítulo apresento as características que definem o processo de solicitação de refúgio do indivíduo LGBTI. Por fim, na conclusão, reluto sobre a ausência de políticas públicas de acolhimento para os refugiados, e os obstáculos enfrentados nos trâmites do processo de refúgio. As abordagens metodológicas utilizadas nessa pesquisa foram a base qualitativa, básica, documental e bibliográfica, com o intuito de entender com mais profundidade o objetivo do artigo, qual seja: investigar as razões que movem a comunidade LGBTI a requerer o refúgio. Palavras-chave: Refúgio. Migração. Políticas Públicas. LGBTI. Direito International.
Considerações Pedagógicas de Educação Inclusiva no Ensino de Crianças com altas Habilidades/ Superdotadas / Pedagogical Considerations of Inclusive Education in Teaching Children with high Skills / Gifted
Authors: Ferreira Francisco Renato Silva , Ifadireó Miguel Melo , Bitu Vanessa De Carvalho Nilo , Alencar Yohana Maria Monteiro Augusto de 
Published: July 2020

Reunir em um mesmo ensaio os conceitos de altas habilidades/ superdotação (AH/SD) é o grande desafio deste ensaio. Destaca-se que são poucos os estudos específicos realizados por especialistas que poderiam contribuir com o sucesso das investigações nas mais distintas ciências do conhecimento humano. O objetivo central deste trabalho está na revisão de algumas discussões proferidas na seara das ciências humanas em relação aos discentes com altas habilidades/ superdotação. A metodologia utilizada é de natureza de pesquisa qualitativa, a partir da proposição de uma revisão sistemática de literatura especializada – tanto em banco de teses de dissertações e teses, quanto em plataformas de artigos científicos - sobre a temática. Importante destacar que o estudo intenta trazer à tona de discussões, algumas contribuições de estudos prévios de expertises reconhecidos por seus pares, tais como os realizados por Ana Oliveira, Vera Capellini e Olga Rodrigues (2020), Brenda Matos e Carina Maciel (2016) e Lurian Mendonça (2015) entre outras importantes investigações. Neste contexto, apresentam-se alguns achados evidenciados ao longo deste trabalho: a) sensibilização do profissional para lidar com a existência de habilidades extraordinárias de crianças com altas habilidades/ superdotadas; b) capacidade de percepção das diferenças e das competências de alguns discentes que nem sempre são visíveis e que precisam ser ativadas pelo educador atento ao talento de seus alunos; c) observação de fatores intelectuais, artísticos, sociais, psicomotores e musicais que podem auxiliar ou dificultar o reconhecimento de crianças (adolescentes, jovens adultos) com altas habilidades/ superdotadas em sala de aula. Palavras-Chave: Altas habilidades. Superdotação. Competências. Ensino e Aprendizagem. Educação.
A Psicopedagogia no Ensino Superior: Relato de Experiência sobre as Principais Queixas dos Acadêmicos em uma Instituição Universitária no Brasil / Psychopedagogy in Higher Education: Experience Report on the Main Complaints of Academics in a University Institution in Brazil
Authors: Sousa Léa Barbosa de , Agrello Marisa Pascarelli 
Published: July 2020

Este artigo tem por intenção apresentar um relato de experiência vivenciada em uma Universidade sobre as principais queixas no acompanhamento de estudantes com dificuldades de aprendizagem. A Psicopedagogia se ocupa das dificuldades de aprendizagem humana e os fatores que interferem no processo de aprendizagem. Este texto propõe uma reflexão sobre os principais assuntos: Psicopedagogia no Ensino Superior e as principais queixas dos Universitários. Dialogando sobre as dificuldades de aprendizagem específicas. Demandas dos atendimentos. Encaminhamentos dos acadêmicos a outros profissionais. Inclusão de alunos com deficiências no Ensino Superior. O acompanhamento Psicopedagógico Universitário é visto pelo Ministério da Educação - MEC como exitoso nas Universidades. As dificuldades de Aprendizagem são muitas e a Psicopedagogia contribui amenizando esse quadro oferecendo apoio psicopedagógico aos estudantes.