bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Smartphone Application for Burn Self-care
Authors: Asghari Amrei Shabnam , Ayatollahi Haleh , Salehi Seyed Hamid 
Published: November 2019

Abstract
Burn treatment and management is largely patient-dependent and self-care education helps reducing tangible and intangible costs as well as improving quality of care. Thus, this study aimed to develop a smartphone application for burn self-care. This research, conducted in 2018, consisted of two phases. Initially, the educational content required for the application was determined based on the literature review and clinicians’ and patients’ perspectives. The setting of the study was the largest burn and plastic surgery hospital in the country. Based on the results derived from the first phase of the study, the application prototype was designed in the Persian language to be used on smartphones. The usability of the application was evaluated by using a standard questionnaire and the data were analyzed by using descriptive statistics. The educational content of the application included eight different areas of self-care; namely, wound care, scar management, care and control of hypertrophic burn scars, nutrition, in-home pain management, mental health, follow-up, and rehabilitation. A specialist was consulted and related texts and images were selected to be included in the application. The application was used by burn patients for a week and users evaluated its usability at a good level. It seems that the application designed in the present study can help to increase patients’ knowledge about burn conditions and improve their self-care skills. Further studies are needed to present the efficiency and effectiveness of the application in practice.
Communicating Cosmopolitanism During Times of Crisis: UNHCR and the World Refugee Day Campaign in the UK and Bulgaria
Authors: Balabanova Ekaterina 
Published: November 2019

AbstractHow can a cosmopolitan message about refugees be communicated in an international political context characterized by growing hostility to outsiders at the national level? This article provides a detailed analysis of a specific World Refugee Day campaign based on extensive access to internal data from the UN Refugee Agency (UNHCR) and interviews with key informants alongside case studies of the campaign in two European countries: the United Kingdom (UK) and Bulgaria. While internal UNHCR assessment suggested successful meeting of pre-set targets, a series of issues around the implementation of message framing and the potential for this to generate action are identified. The article applies ideas about the communication of distant suffering to explore how World Refugee Day campaigns operate as interventions into global public discourse. The analysis of the campaign framing finds that it maximized space for solidaristic understanding of the refugee issue and reflexivity. However, the article argues that the communication of these ideas is impacted by the practical and organizational challenges (and opportunities) of developing a professional communication strategy in the context of a rapidly changing media and political environment.
Transhumanism, Moral Perfection, and Those 76 Trombones
Authors: Koch Tom 
Published: November 2019

Abstract
Transhumanism advances an ideology promising a positive human advance through the application of new and as yet unrealized technologies. Underlying the whole is a libertarian ethos married to a very Christian eschatology promising a miraculous transformation that will answer human needs and redress human failings. In this paper, the supposedly scientific basis on which transhumanist promises are built is critiqued as futurist imaginings with little likelihood of actualization. Transhumanists themselves are likened to the affable con man Professor Harold Hill who, in The Music Man, describes as dire social problems whose solution is a youth band he seeks to sell but has no intention of building. Even were some of the transhumanist imaginings to be realized, I argue, the result would be a dystopia in which the few received benefits denied to the many. In advancing imaginary technologies as a solution to human needs, transhumanists and their bioethical fellow travelers handily avoid discussion of or advocacy for the kind of pedestrian social actions that demonstrably could achieve many of their purported goals. So their enthusiasms, I conclude, are not merely fanciful but damaging to the humanist goals they pretend to advance.
Germline Testing for Patients With BRCA1/2 Mutations on Somatic Tumor Testing
Authors: Vlessis Katherine , Purington Natasha , Chun Nicolette , Haraldsdottir Sigurdis , Ford James M 
Published: November 2019

Abstract

Background
The National Comprehensive Cancer Network (NCCN) recommends germline testing for pathogenic BRCA1/2 mutations identified by somatic tumor sequencing. The aim of this study was to explore whether patients at Stanford with somatic BRCA1/2 mutations were recommended germline testing in accordance with NCCN guidelines.

Methods
We retrospectively collected all Stanford patients with BRCA1/2 mutations found by tumor sequencing. Medical records were reviewed for each patient to identify those recommended germline testing. A multivariable logistic regression model was fit associating baseline characteristics with whether or not a recommendation was made.

Results
Of 164 participants, 51 (31.1%) had no recommendation for germline testing. Of the 97 available germline-testing results, 54 (55.7%) were positive for pathogenic BRCA1/2 mutations. After adjusting for possible confounders, patients with genitourinary cancer (odds ratio [OR] = 0.03, 95% confidence interval [CI] = 0.00 to 0.03; P = .003), lung cancer (OR = 0.04, 95% CI = 0.01 to 0.21; P &lt; .001), sarcoma (OR = 0.02, 95% CI = 0.00 to 0.14; P &lt; .001), skin cancer (OR = 0.01, 95% CI = 0.98 to 1.03; P = .002), or “other” diagnoses (OR = 0.01, 95% CI = 0.00 to 0.16; P &lt; .001) were statistically significantly less likely to be recommended germline testing compared with patients with breast or gynecological cancers.

Conclusions
Our study highlights the importance of provider education outside of the oncologic specialties typically associated with BRCA-related cancers and continued exploration of referrals to genetics for germline testing on the basis of somatic findings.
Ancient DNA Reconstructs the Genetic Legacies of Precontact Puerto Rico Communities
Authors: Nieves-Colón Maria A , Pestle William J , Reynolds Austin W , Llamas Bastien , de la Fuente Constanza , Fowler Kathleen , Skerry Katherine M , Crespo-Torres Edwin , Bustamante Carlos D , Stone Anne C 
Published: November 2019

AbstractIndigenous peoples have occupied the island of Puerto Rico since at least 3000 BC. Due to the demographic shifts that occurred after European contact, the origin(s) of these ancient populations, and their genetic relationship to present-day islanders, are unclear. We use ancient DNA to characterize the population history and genetic legacies of precontact Indigenous communities from Puerto Rico. Bone, tooth, and dental calculus samples were collected from 124 individuals from three precontact archaeological sites: Tibes, Punta Candelero, and Paso del Indio. Despite poor DNA preservation, we used target enrichment and high-throughput sequencing to obtain complete mitochondrial genomes (mtDNA) from 45 individuals and autosomal genotypes from two individuals. We found a high proportion of Native American mtDNA haplogroups A2 and C1 in the precontact Puerto Rico sample (40% and 44%, respectively). This distribution, as well as the haplotypes represented, supports a primarily Amazonian South American origin for these populations and mirrors the Native American mtDNA diversity patterns found in present-day islanders. Three mtDNA haplotypes from precontact Puerto Rico persist among Puerto Ricans and other Caribbean islanders, indicating that present-day populations are reservoirs of precontact mtDNA diversity. Lastly, we find similarity in autosomal ancestry patterns between precontact individuals from Puerto Rico and the Bahamas, suggesting a shared component of Indigenous Caribbean ancestry with close affinity to South American populations. Our findings contribute to a more complete reconstruction of precontact Caribbean population history and explore the role of Indigenous peoples in shaping the biocultural diversity of present-day Puerto Ricans and other Caribbean islanders.
Developmental Systems Drift and the Drivers of Sex Chromosome Evolution
Authors: Cauret Caroline M S , Gansauge Marie-Theres , Tupper Andrew S , Furman Benjamin L S , Knytl Martin , Song Xue-Ying , Greenbaum Eli , Meyer Matthias , Evans Ben J 
Published: November 2019

AbstractPhenotypic invariance—the outcome of purifying selection—is a hallmark of biological importance. However, invariant phenotypes might be controlled by diverged genetic systems in different species. Here, we explore how an important and invariant phenotype—the development of sexually differentiated individuals—is controlled in over two dozen species in the frog family Pipidae. We uncovered evidence in different species for 1) an ancestral W chromosome that is not found in many females and is found in some males, 2) independent losses and 3) autosomal segregation of this W chromosome, 4) changes in male versus female heterogamy, and 5) substantial variation among species in recombination suppression on sex chromosomes. We further provide evidence of, and evolutionary context for, the origins of at least seven distinct systems for regulating sex determination among three closely related genera. These systems are distinct in their genomic locations, evolutionary origins, and/or male versus female heterogamy. Our findings demonstrate that the developmental control of sexual differentiation changed via loss, sidelining, and empowerment of a mechanistically influential gene, and offer insights into novel factors that impinge on the diverse evolutionary fates of sex chromosomes.
A DNA G-quadruplex/i-motif hybrid
Authors: Chu Betty , Zhang Daoning , Paukstelis Paul J 
Published: November 2019

Abstract
DNA can form many structures beyond the canonical Watson–Crick double helix. It is now clear that noncanonical structures are present in genomic DNA and have biological functions. G-rich G-quadruplexes and C-rich i-motifs are the most well-characterized noncanonical DNA motifs that have been detected in vivo with either proscribed or postulated biological roles. Because of their independent sequence requirements, these structures have largely been considered distinct types of quadruplexes. Here, we describe the crystal structure of the DNA oligonucleotide, d(CCAGGCTGCAA), that self-associates to form a quadruplex structure containing two central antiparallel G-tetrads and six i-motif C–C+ base pairs. Solution studies suggest a robust structural motif capable of assembling as a tetramer of individual strands or as a dimer when composed of tandem repeats. This hybrid structure highlights the growing structural diversity of DNA and suggests that biological systems may harbor many functionally important non-duplex structures.
Screening, Brief Intervention, and Referral to Treatment for Prenatal Alcohol Use and Cigarette Smoking: A Survey of Academic and Community Health Care Providers
Authors: Ordean Alice , Forte Milena , Selby Peter , Grennell Erin 
Published: November 2019

Objectives:
Prenatal alcohol and cigarette smoking are associated with numerous adverse pregnancy outcomes. Screening, Brief Intervention, and Referral to Treatment (SBIRT) represents a standardized approach; however, implementation in routine pregnancy care remains a challenge. The purpose of the study was to determine current practices, barriers to implementation, and education needs of healthcare providers utilizing SBIRT to address prenatal alcohol and cigarette smoking.

Methods:
We conducted a survey of 118 providers including family physicians, midwives, and obstetricians practicing at 2 Toronto hospitals: community-based teaching site and fully affiliated academic health sciences center.

Results:
The response rate was 79%. Almost all providers reported screening every pregnant woman for alcohol and smoking status. Brief intervention was offered by fewer providers. Education and supportive counseling were reported by a higher percentage of providers for prenatal cigarette smoking in comparison to alcohol use. Furthermore, up to 60% referred pregnant women to treatment programs for alcohol and cigarette smoking. A significantly higher number of community-based providers reported referring pregnant women to addiction treatment programs. Barriers to interventions included a perceived lack of appropriate resources, training, and clinical pathways.

Conclusion:
Healthcare providers report universal screening for prenatal alcohol and cigarette smoking; however, brief intervention and referral to treatment are more limited practices. There is a need for education of all providers regarding effective brief counseling strategies and referral to appropriate treatment resources. Development of clinical care pathways may also increase adoption of all components of SBIRT for prenatal alcohol use and cigarette smoking.
Perceived Benefits and Barriers to a Career in Neuroanesthesiology: A Pilot Survey of Anesthesiology Clinicians
Authors: Rajan Shobana , Theard Marie A. , Easdown Jane , Goyal Keshav , Pasternak Jeffrey J. 
Published: November 2019

Background:
Despite advances in perioperative neuroscience, there is low interest among anesthesiology trainees to pursue subspecialty training in neuroanesthesiology. We conducted a pilot survey to assess attitudes about neuroanesthesiology fellowship training.

Materials and Methods:
A confidential survey was distributed to an international cohort of anesthesiology attendings and trainees between January 15, 2017 and February 26, 2017.

Results:
A total of 463 responses were received. Overall, 309 (67%), 30 (6%), 116 (25%), and 8 (2%) of respondents identified themselves as attendings, fellows, residents, and “other,” respectively. In total, 390 (84%) of respondents were from the United States. Individuals typically pursue anesthesiology fellowship training because of interest in the subspecialty, acquisition of a special skill set, and the role of fellowship training in career planning and advancement. Overall, 64% of attendings, 56% of fellows, and 55% of residents favored accreditation of neuroanesthesiology fellowships, although opinion was divided regarding the role of accreditation in increasing interest in the specialty. Respondents believe that increased opportunities for research and greater exposure to neurocritical care and neurological monitoring methods would increase interest in neuroanesthesiology fellowship training. Perceived barriers to neuroanesthesiology fellowship training were perceptions that residency provides adequate training in neuroanesthesiology, that a unique skill set is not acquired, and that there are limited job opportunities available to those with neuroanesthesiology fellowship training.

Conclusions:
In this pilot survey, we identified several factors that trainees consider when deciding to undertake subspecialty training and barriers that might limit interest in pursuing neuroanesthesiology subspecialty training. Our findings may be used to guide curricular development and identify factors that might increase interest among trainees in pursuing neuroanesthesiology fellowship training.
Effect of Stimulation Rate on Speech Understanding in Older Cochlear-Implant Users
Authors: Shader Maureen J. , Nguyen Nicole , Cleary Miranda , Hertzano Ronna , Eisenman David J. , Anderson Samira , Gordon-Salant Sandra , Goupell Matthew J. 
Published: November 2019

Objectives:Cochlear implants (CIs) are considered a safe and effective intervention for more severe degrees of hearing loss in adults of all ages. Although older CI users ≥65 years of age can obtain large benefits in speech understanding from a CI, there is a growing body of literature suggesting that older CI users may not perform as well as younger CI users. One reason for this potential age-related limitation could be that default CI stimulation settings are not optimal for older CI users. The goal of this study was to determine whether improvements in speech understanding were possible when CI users were programmed with nondefault stimulation rates and to determine whether lower-than-default stimulation rates improved older CI users’ speech understanding.Design:Sentence recognition was measured acutely using different stimulation rates in 37 CI users ranging in age from 22 to 87 years. Maps were created using rates of 500, 720, 900, and 1200 pulses per second (pps) for each subject. An additional map using a rate higher than 1200 pps was also created for individuals who used a higher rate in their clinical processors. Thus, the clinical rate of each subject was also tested, including non-default rates above 1200 pps for Cochlear users and higher rates consistent with the manufacturer defaults for subjects implanted with Advanced Bionics and Med-El devices. Speech understanding performance was evaluated at each stimulation rate using AzBio and Perceptually Robust English Sentence Test Open-set (PRESTO) sentence materials tested in quiet and in noise.Results:For Cochlear-brand users, speech understanding performance using non-default rates was slightly poorer when compared with the default rate (900 pps). However, this effect was offset somewhat by age, in which older subjects were able to maintain comparable performance using a 500-pps map compared with the default rate map when listening to the more difficult PRESTO sentence material. Advanced Bionics and Med-El users showed modest improvements in their overall performance using 720 pps compared with the default rate (>1200 pps). On the individual-subject level, 10 subjects (11 ears) showed a significant effect of stimulation rate, with 8 of those ears performing best with a lower-than-default rate.Conclusions:Results suggest that default stimulation rates are likely sufficient for many CI users, but some CI users at any age can benefit from a lower-than-default rate. Future work that provides experience with novel rates in everyday life has the potential to identify more individuals whose performance could be improved with changes to stimulation rate.
Effects of Surface Topography and Chemistry on Polyether-Ether-Ketone (PEEK) and Titanium Osseointegration
Authors: Torstrick F. Brennan , Lin Angela S.P. , Safranski David L. , Potter Daniel , Sulchek Todd , Lee Christopher S.D. , Gall Ken , Guldberg Robert E. 
Published: November 2019

Study Design.
An in vivo study examining the functional osseointegration of smooth, rough, and porous surface topographies presenting polyether-ether-ketone (PEEK) or titanium surface chemistry.

Objective.
To investigate the effects of surface topography and surface chemistry on implant osseointegration.

Summary of Background Data.
Interbody fusion devices have been used for decades to facilitate fusion across the disc space, yet debate continues over their optimal surface topography and chemistry. Though both factors influence osseointegration, the relative effects of each are not fully understood.

Methods.
Smooth, rough, and porous implants presenting either a PEEK or titanium surface chemistry were implanted into the proximal tibial metaphyses of 36 skeletally mature male Sprague Dawley rats. At 8 weeks, animals were euthanized and bone–implant interfaces were subjected to micro-computed tomography analysis (n = 12), histology (n = 4), and biomechanical pullout testing (n = 8) to assess functional osseointegration and implant fixation.

Results.
Micro-computed tomography analysis demonstrated that bone ingrowth was 38.9 ± 2.8% for porous PEEK and 30.7 ± 3.3% for porous titanium (P = 0.07). No differences in fixation strength were detected between porous PEEK and porous titanium despite titanium surfaces exhibiting an overall increase in bone–implant contact compared with PEEK (P < 0.01). Porous surfaces exhibited increased fixation strength compared with smooth and rough surfaces regardless of surface chemistry (P < 0.05). Across all groups both surface topography and chemistry had a significant overall effect on fixation strength (P < 0.05), but topography accounted for 65.3% of the total variance (ω2 = 0.65), whereas surface chemistry accounted for 5.9% (ω2 = 0.06).

Conclusions.
The effect of surface topography (specifically porosity) dominated the effect of surface chemistry in this study and could lead to further improvements in orthopedic device design. The poor osseointegration of existing smooth PEEK implants may be linked more to their smooth surface topography rather than their material composition.

Level of Evidence: N/A
Self-Experienced Trunk Appearance in Individuals With and Without Idiopathic Scoliosis
Authors: Savvides Panayiotis , Gerdhem Paul , Grauers Anna , Danielsson Aina , Diarbakerli Elias 
Published: November 2019

Study Design.
Cross-sectional.

Objective.
The aim of this study was to describe the self-experienced trunk appearance in individuals with and without idiopathic scoliosis.

Summary of Background Data.
Idiopathic scoliosis is the most common spinal deformity. A large scoliotic deformity increases the risk of back pain and pulmonary dysfunction. The deformity has also a psychological impact.

Methods.
The pictorial part of the spinal appearance questionnaire (pSAQ) was administered to 1416 individuals with idiopathic scoliosis (386 untreated, 529 brace treated, 501 surgically treated) and 272 individuals without scoliosis from the general population. Comparisons were made between individuals with and without scoliosis, between treatment groups and sex in the scoliosis group.

Results.
Mean (95% confidence interval) age of the individuals with scoliosis was 36.2 (35.5–36.9) years and for the individuals without scoliosis 40.2 (37.9–42.4). pSAQ total was 12.3 (12.1–12.5) for individuals with scoliosis and 7.4 (7.3–7.6) for individuals without scoliosis (P < 0.001, adjusted for age and sex). pSAQ total was 11.5 (11.1–11.9) for untreated, 13.0 (12.6–13.3) for brace treated, and 12.3 (11.9–12.6) for surgically treated individuals (P < 0.001, adjusted for sex and curve size). The pSAQ total between males and females with idiopathic scoliosis did not differ (P = 0.22 adjusted for age and curve size).

Conclusion.
This study shows that individuals with idiopathic scoliosis have more concern about their body appearance than individuals without scoliosis. Untreated individuals are not as bothered of their spinal appearance as treated individuals. Males and females with scoliosis do not differ significantly in the perception of their spinal appearance.

Level of Evidence: 3