bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles
Authors: He Yi , Ronsein Graziella E. , Tang Chongren , Jarvik Gail P. , Davidson W. Sean , Kothari Vishal , Song Hyun D. , Segrest Jere P. , Bornfeldt Karin E. , Heinecke Jay W. 
Published: August 2020

Rationale:
HDL (high-density lipoprotein) may be cardioprotective because it accepts cholesterol from macrophages via the cholesterol transport proteins ABCA1 (ATP-binding cassette transporter A1) and ABCG1 (ATP-binding cassette transporter G1). The ABCA1-specific cellular cholesterol efflux capacity (ABCA1 CEC) of HDL strongly and negatively associates with cardiovascular disease risk, but how diabetes mellitus impacts that step is unclear.

Objective:
To test the hypothesis that HDL’s cholesterol efflux capacity is impaired in subjects with type 2 diabetes mellitus.

Methods and Results:
We performed a case-control study with 19 subjects with type 2 diabetes mellitus and 20 control subjects. Three sizes of HDL particles, small HDL, medium HDL, and large HDL, were isolated by high-resolution size exclusion chromatography from study subjects. Then we assessed the ABCA1 CEC of equimolar concentrations of particles. Small HDL accounted for almost all of ABCA1 CEC activity of HDL. ABCA1 CEC―but not ABCG1 CEC―of small HDL was lower in the subjects with type 2 diabetes mellitus than the control subjects. Isotope dilution tandem mass spectrometry demonstrated that the concentration of SERPINA1 (serpin family A member 1) in small HDL was also lower in subjects with diabetes mellitus. Enriching small HDL with SERPINA1 enhanced ABCA1 CEC. Structural analysis of SERPINA1 identified 3 amphipathic α-helices clustered in the N-terminal domain of the protein; biochemical analyses demonstrated that SERPINA1 binds phospholipid vesicles.

Conclusions:
The ABCA1 CEC of small HDL is selectively impaired in type 2 diabetes mellitus, likely because of lower levels of SERPINA1. SERPINA1 contains a cluster of amphipathic α-helices that enable apolipoproteins to bind phospholipid and promote ABCA1 activity. Thus, impaired ABCA1 activity of small HDL particles deficient in SERPINA1 could increase cardiovascular disease risk in subjects with diabetes mellitus.
The Moisture Budget of Tropical Cyclones in HighResMIP Models: Large-Scale Environmental Balance and Sensitivity to Horizontal Resolution
Authors: Vannière Benoît , Roberts Malcolm , Vidale Pier Luigi , Hodges Kevin , Demory Marie-Estelle , Caron Louis-Philippe , Scoccimarro Enrico , Terray Laurent , Senan Retish 
Published: August 2020

AbstractPrevious studies have shown that the number, intensity, and structure of simulated tropical cyclones (TCs) in climate models get closer to the observations as the horizontal resolution is increased. However, the sensitivity of tropical cyclone precipitation and moisture budget to changes in resolution has received less attention. In this study, we use the five-model ensemble from project PRIMAVERA/HighResMIP to investigate the systematic changes of the water budget of tropical cyclones in a range of horizontal resolutions from 1° to 0.25°. Our results show that, despite a large change in the distribution of TC intensity with resolution, the distribution of precipitation per TC (i.e., averaged in a 5° radial cap) does not change significantly. This result is explained by the fact that low- and high-resolution models represent equally well the large-scale balance that characterizes the moisture budget of TCs, with the radius of the moisture source extending to ~15° from the center of the TC (i.e. well beyond the TC edge). The wind profile is found to converge in the low and high resolutions for radii > 5°, resulting in a moisture flux convergence into the TC of similar magnitude at low and high resolutions. In contrast to precipitation per TC, TC intensity does increase at higher resolution and this is explained by the larger surface latent heat flux near the center of the storm, which leads to an increase in equivalent potential temperature and warmer core anomalies, although this extra latent heat represents a negligible contribution to the overall moisture budget. We discuss the complication arising from the choice of the tracking algorithm when assessing the impact of model resolution.
‘Mini-Microsuture Technique’ for Phonosurgery: A New Simplified Method
Authors: Denizoğlu İsmail İlter , BaŞer Engin 
Published: August 2020

Introduction: Phonomicrolaryngeal surgery involves the surgical treatment of benign disorders of the vocal folds. Postoperative scar tissue in vocal fold mucosa is undesired because mucosal hypodynamia may lead to prolonged impairment in voice quality. This study aims to present and share the outcomes of a new endolaryngeal suture technique. Methods: This study consists of patients who underwent vocal fold surgery followed by endolaryngeal microscopic suturation with a technique that we call the “mini-microsuture technique” between January 2018-December 2019. Videolaryngoscopic images were examined to observe the tissue healing process (suture elimination time, mucosal scar status, and wave pattern) at the first and the fourth week postoperatively. Results: A retrospective analysis was made in 144 (57 males (39.5%) and 87 females (60.5%)) patients who underwent phonomicrosurgery with “Mini-microsuture technique.” Mean age was 40.61 ± 13.54 (10-78) years. There were multiple pathological lesions in 41.66% (n: 60) of our patients, and 58.33% (n: 84) of them had single-lesion. 63.88% (n: 92) of the patients had bilateral vocal fold lesions where 36.22% (n: 52) of the patients had pathology in one vocal fold. Conclusions: The “mini-microsuture technique” is an easy and functional procedure that can be performed by a single surgeon under microscopy, which minimizes tissue trauma, prevents mucosal hypodynamia, and provides a better anatomical structure postoperatively for a symmetrical vibration. The technique does not significantly prolong operation time when mastered and is a cost-effective method in which surgery which can be concluded using a single suture material.
Left Ear Hearing Predicts Functional Activity in the Brains of Patients with Alzheimer’s Disease Dementia
Authors: Aylward Alana , Naidu Susan R. , Mellum Catherine , King Jace B. , Jones Keith G. , Anderson Jeffrey S. , Foster Norman L. , Gurgel Richard K. 
Published: August 2020

Objectives: To determine whether central speech processing ability, as measured by hearing in noise, differs between right and left ears in adults with Alzheimer’s disease related dementia (AD) as well as whether differences in central speech processing ability correlate with an fMRI-based measurement of global functional brain connectivity. Methods: This prospective study was carried out at a tertiary referral center. Patients with an AD diagnosis and pure tone averages 40 dB HL or better were included. They were examined using resting-state fMRI and underwent central audiometric testing using the Dichotic Sentence Identification Test (DSI), the Dichotic Digits Test (DD), and the Synthetic Sentence Identification Test (SS), which test hearing in noise. DSI scores were correlated with resting-state fMRI connectivity between 361 distinct gray matter brain regions of interest (ROIs). Average global connectivity was calculated as mean functional connectivity between an ROI and the other 360 regions, a quantitative marker representing overall functional connectivity in the brain. Results: Sixteen subjects had adequate fMRI and hearing data. The average age was 71.5 years old (±6.0). The average DSI score for the left ear was 40% (±34%) compared to 90% (±10%) in the right ear ( P < .001). No difference between ears was noted on the DD. SS does not differentiate between ears, but worsening scores were noted with increasing background noise. Of the fMRI ROIs, 269 of the 361 had multiple comparison corrected significant correlations between global connectivity and DSI of the left ear ( P = .004, r = .673), and all 269 showed higher functional connectivity for individuals with higher left DSI score. No correlations between DSI of the right ear and functional connectivity were found. Conclusions: Correlation was noted between left sided DSI and functional connectivity in patients with AD. Auditory input from the left ear was more susceptible to impairment, suggesting that side-specific auditory input may influence central auditory processing.
The art and science of systemic wellness in Black communities: Qualitative evaluation of a multimodal theatrical production
Authors: Addie Yewande O , Strekalova Yulia A Levites , Pufahl Jeffrey 
Published: August 2020

Background: Edutainment has long been used as a strategy in health promotion and public health wellness interventions. In March 2019, a large US southeastern university hosted a multimodal theatrical production entitled From Colored to Black (FCTB). The play used a historical lens to broadly address social determinants of health such as disparities in education, access to health services, fair housing and health outcomes. This creative intervention was intended to encourage progressive, justice-oriented attitudes about historically disenfranchised Black communities in North Central Florida. Methods: Driven by an arts-based education approach and constructs from narrative transportation theory, the study employed directed qualitative content analysis to evaluate audience commentary and examine how a play on historic health inequities in Black communities could activate cognition, emotion and imagination for critical thinking about present-day wellbeing. Results: Qualitative survey data in response to the artistic presentation revealed the following subthemes: fascination, assumed truthfulness, satisfaction, feelings of inspiration, enthusiasm, negative attitudes, hopelessness and emotional disconnect. Conclusions: Edutainment continues to be a strong intervention tool. Feedback indicates audience members experienced both highly immersive moments and low transportation-inducing points that ultimately influenced critical reflection on some of the themes addressed in the play.
Urban upbringing and psychiatric disorders in the United States: A racial comparison
Authors: Oh Hans , Nicholson Harvey L , Koyanagi Ai , Jacob Louis , Glass Joe 
Published: August 2020

Background: Studies that link urbanicity to mental health are mixed depending on outcome and context. More research is needed to examine whether the urban upbringing effect holds true across racial populations in a large and diverse country like the United States. Methods: We analyzed two large datasets that were administered contemporaneously with similar methods: The National Comorbidity Survey-Replication (NCS-R, Whites) and the National Survey of American Life (NSAL, Blacks). We ran multivariable logistic regression models to examine the associations between area of upbringing (urban/large city, other, rural) and six psychiatric disorders, controlling for sex, age, years of education and income-to-poverty ratio (and ethnicity in the NSAL). We performed these analyses in both the NCS-R and the NSAL separately. Results: The majority (58.97%) of the White sample grew up in the ‘other’ category (i.e. small town, small city, or suburb of a large city), whereas a much larger percentage (39.89%) of the Black sample grew up in a large city. In the White sample, urban upbringing was not associated with any of the psychiatric disorders at a conventional level of statistical significance. In the Black sample, urban upbringing was associated with greater odds of having mood disorder, alcohol use disorder and drug use disorder, but was not significantly associated with anxiety disorders, PTSD, or eating disorders. Conclusions: Urban upbringing was not associated with psychiatric disorders among Whites, but was associated with greater odds of mood disorders, alcohol us disorder and drug use disorder among Blacks. Future research can elucidate how differences in urban upbringing between Whites and Blacks are linked to differences in risk for psychiatric disorders.
The information phase of accountability: The role of management boards in European Union agencies
Authors: Font Nuria , Pérez-Durán Ixchel 
Published: August 2020

The creation of European Union agencies has prompted normative and theoretical discussions about their accountability and democratic legitimacy. This study examines the extent to which different features concerning the institutional design of agencies incentivize information provision on their performance. To do so, it measures four aspects for which their governing bodies are expected to provide information: governance decisions, policy performance, financial issues, and interactions with stakeholders. Using a new data set of informative statements included in 199 annual activity reports of 29 agencies during the period 2010–2016, this study demonstrates that formal accountability positively affects information provision on governance and policy issues, and that the establishment of scientific bodies within agencies improves information provision on governance aspects, policy performance and their interactions with stakeholders. Finally, this article finds that agencies that perform more direct regulation are subject to greater transparency demands about their governance decisions and stakeholder interactions. Points for practitioners The study provides practitioners with an analytical tool for assessing the provision of information about the decisions and actions of management boards on governance issues, policy performance, financial aspects and their interactions with stakeholders.
(Dis)ability-informed mentors support occupational performance for college students with learning disabilities and attention-deficit/hyperactivity disorders through problem-solving and a focus on strengths
Authors: Kreider Consuelo M , Medina Sharon , Koedam Hannah M. 
Published: August 2020

Introduction Students with learning disabilities and attention-deficit/hyperactivity disorder are well represented on college campuses. However, they experience challenges to meeting occupational and role expectations associated with being in college. Mentors serve as natural supports for young people within college environments. This study investigates the ways in which graduate-student mentors, who were supported in understanding learning disabilities and attention-deficit/hyperactivity disorder and their mentee’s strengths and challenges through an occupational lens, provided problem-solving supports for undergraduate mentees with learning disabilities and attention-deficit/hyperactivity disorder. Methods Thematic qualitative analysis was used to investigate problem-solving supports provided by mentors ( n = 57) of undergraduate mentees ( n = 52) with learning disabilities and attention-deficit/hyperactivity disorder. Results Three themes, executive functioning, adult life skills, and academics, represent areas in which mentors worked with mentees in guiding and co-creating strategies to address academic, social, and daily life challenges. Mentors’ understanding of their mentees’ disability-related challenges and strengths within everyday life situations was important for fostering the occupational performance of mentees. Conclusion The inclusion of biopsychosocial approaches is needed in the development of disability-related mentorship interventions where occupational therapists can leverage disciplinary understanding of disabilities and the fostering of occupational performance to support social functioning and participation in college.
The impact of intradialytic cycling on the removal of protein-bound uraemic toxins: A randomised cross-over study
Authors: De Vos Celine , Lemarcq Laure , Dhondt Annemieke , Glorieux Griet , Van Biesen Wim , Eloot Sunny 
Published: August 2020

The evidence on impact of intradialytic exercise on the removal of urea, is conflictive. Impact of exercise on kinetics of serum levels of protein-bound uraemic toxins, known to exert toxicity and to have kinetics dissimilar of those of urea, has so far not been explored. Furthermore, if any effect, the most optimal intensity, time point and/or required duration of intradialytic exercise to maximise removal remain obscure. We therefore studied the impact of different intradialytic cycling schedules on the removal of protein-bound uraemic toxins during haemodialysis (HD). This randomised cross-over study included seven stable patients who were dialysed with an FX800 dialyser during three consecutive midweek HD sessions of 240 min: (A) without cycling; (B) cycling for 60 min between 60th and 120th minutes of dialysis; and (C) cycling for 60 min between 150th and 210th minutes, with the same cycling load as in session B. Blood and dialysate flows were respectively 300 and 500 mL/min. Blood was sampled from the blood inlet at different time points, and dialysate was partially collected (300 mL/h). Small water soluble solutes and protein-bound toxins were quantified and intradialytic reduction ratios (RR) and overall removal were calculated per solute. Total solute removal and reduction ratios were not different between the three test sessions, except for the reduction ratios RR60–120 and RR150–210 for potassium. In conclusion, we add evidence to the existing literature that, regardless of the timing within the dialysis session, intradialytic exercise has no impact on small solute clearance, and demonstrated also a lack of impact for protein-bound solutes.
Home Care Nursing Visits and Same-Day Emergency Department Use: Which Patients Are Most at Risk?
Authors: Schumacher Connie , Jones Aaron , Costa Andrew P. 
Published: August 2020

Background Home care patients are a growing group of community-dwelling older adults with complex care needs and high health service use. Adult home care patients are at high risk for emergency department (ED) visits, which is greater on the same day as a nursing visit. Purpose The purpose of this study was to examine whether common nursing indicators modified the association between nursing visits and same-day ED visits. Methods A case-crossover design within a retrospective cohort of adult home care patients in Ontario. Results A total of 11,840 home care nursing patients were analyzed. Home care patients who received a home nursing visit were more likely to go the ED afterhours on the same day with a stronger association for visits not admitted to the hospital. Having a urinary catheter increased the risk of a same-day ED visit (OR: 1.78 (95% CI 1.15–1.60) vs. 1.21 (95% CI 1.15–1.28)). No other clinical indicator modified the association. Conclusions The findings of this study can be used to inform care policies and practices for home care nurses in the management of indwelling urinary catheter complications. Further examination of system factors such as capacity and resources available to respond to catheter related complications in the community setting are recommended.
Navigating from Brand Image to Patient Loyalty: Mediating Effect of Service Quality and Patient Satisfaction
Authors: Vimla  , Taneja Udita 
Published: August 2020

Purpose: This study aims to analyse brand image (BI)–service quality (SQ)–patient satisfaction (PS)–loyalty in healthcare by understanding BI and SQ modelled as multidimensional constructs in Indian healthcare. Furthermore, the mediating effect from BI to loyalty through SQ and PS is examined. Design/methodology/approach: Analysis of survey data of 210 patients from Indian hospitals reveals that BI directly affects SQ, PS and loyalty, that SQ directly influences PS, that PS directly influences loyalty of patients and that PS and BI are significant determinants of loyalty. Findings: Our findings suggest that BI has both a direct and indirect (through SQ and PS) impact on loyalty of patients. Moreover, the mediation of BI to loyalty through SQ and PS is partial and complementary mediation. Practical implications: By understanding the relationship between BI, SQ, PS and loyalty, managers will be able to better understand the mechanism to enhance loyalty. As BI impacts loyalty indirectly through SQ and PS, managers need to improve quality, which will enhance satisfaction of patients and thus help in the formation of loyal patients. Originality/value: This study shows how the mediating effect of SQ and PS can be used to improve patient loyalty by building positive BI.
Complications Associated With Midline Incision for Insertional Achilles Tendinopathy
Authors: Hörterer Hubert , Baumbach Sebastian Felix , Oppelt Sonja , Böcker Wolfgang , Harrasser Norbert , Walther Markus , Polzer Hans 
Published: August 2020

Background: The midline-incision trans-achillary approach (MITA) is frequently used for addressing all pathologies of insertional Achilles tendinopathy (IAT). The aim of this study was to assess the complication rate and possible influencing factors following a MITA for IAT treatment. Methods: Presented is a retrospective cohort study with current follow-up. Patients treated surgically by a MITA, addressing all pathologies of IAT, between January 2010 and October 2016 at a single reference center with at least 12 months of follow-up were included. General demographics (age, sex, and body mass index), medical history, surgical details (individual and sum of pathologies addressed), and duration of in-hospital stay were assessed. Patient satisfaction, shoe conflict, current employment status, time to return to sports, and type of sports were recorded using a custom questionnaire. Standard statistics, chi-square, and t tests were performed using SPSS. A total of 118 patients (follow-up, 63.4%) with a mean age (± SD) of 50 ± 12 years and a mean final follow-up time (± SD) of 4.2 ± 2.1 were included. Results: Fourteen percent of patients had a minor complication, the majority (75%) of which were surgical site infections. Forty-one percent were limited in their shoe selection, and 32% reported a shoe conflict. Seventy-eight percent were very satisfied, and 89% would recommend the surgery. Neither the individual surgical procedures, their sum, nor any other parameter showed a significant influence on the complication rate. The only factor negatively affecting patient satisfaction was a shoe conflict ( P < .001). Conclusion: The MITA for IAT treatment showed a moderate minor complication rate with good midterm patient satisfaction. However, the approach might predispose patients to shoe conflict, which negatively influences their satisfaction. Level of Evidence: Level IV, retrospective cohort study.