bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress-Related Growth and Perceived Health in Japanese People Living with HIV: Web-Based Nationwide Participatory Research.
Authors: Togari Taisuke , Inoue Yoji , Oshima Gaku , Abe Sakurako , Hosokawa Rikuya , Takaku Yosuke 
Published: September 2020

Abstract
Background: For Japanese people living with HIV, this study aimed at the following: verifying the three-factor model of stress-related growth scales; confirming the impact of stress-related growth on mental health and physical symptoms; and determining differences in the effects of stress-related growth on health by time since HIV diagnosis.　Methods: A cross-sectional anonymous self-administered online survey which was prepared on the basis of the participatory research method was conducted from July 2013 to February 2014 and from December 2016 to July 2017 for all Japanese web users living with HIV. We analyzed the data of 1,422 participants who responded regarding the number of years since diagnosis and where transmission was sexual. The mean age (standard deviation) was 38.6 (8.3) years.　Results: Stress-related growth comprises three factors: self-perception, interpersonal relationships, and philosophy of life. In the group over 4 years since diagnosis, logistic and Poisson regression analysis simultaneously including all the scales showed a positive effect; in the group with less than 4 years since diagnosis, such an association was found only for self-perception. In the group with over 4 years since diagnosis, positive growth in interpersonal relationships and self-perception led to reduced somatic symptoms; however, philosophy of life was linked to increased physical symptoms. When the group with less than 4 years since diagnosis was included, no correlation was evident with philosophy of life; positive growth in self-perception led to reduced physical symptoms; positive changes in interpersonal relationships produced increased physical symptoms.　Conclusions: Toward assisting people living with HIV/AIDS, we found that personal and group relationships played an important role in creating positive changes regarding respondents’ perceptions of life and other people.
The Volume of General Surgery Emergency Cases in a Government Hospital During the COVID -19 Pandemic and Two Other Periods: A Comparative Study
Authors: shakra Ibrahim abu , Bez Maxim , Ganam Samer , Francis Rula , Muati Amir , Bickel Amitai , Merei Fahed , Talmi Ziv , Kamal Khatib , Kakiashvili Eli 
Published: September 2020

Abstract
Objective: We compared characteristics of patients admitted to a northern Israeli hospital with common surgical complaints during three periods: the lockdown due to the COVID-19 outbreak, the Second Lebanon War in 2006, and a regular period. Background: During March and April 2020, reductions in non-COVID-19 hospital admissions were observed around the world. Elective surgeries, visits with general practitioners, and diagnoses of medical emergencies were consequently delayed.Methods: Demographic, medical, laboratory, imaging, intraoperative, and pathological data were collected from electronic medical files of patients who received emergency treatment at the surgery department of a single hospital in northern Israel. We compared characteristics of patients who were admitted with various conditions during three periods. Results: Patients’ mean age and most of the clinical parameters assessed were similar between the periods. However, pain was reportedly higher during the COVID-19 than the control period (8.7 vs. 6.4 on a 10-point visual analog scale, P < 0.0001). During the COVID-19 outbreak, the Second Lebanon War, and the regular period, the mean numbers of patients admitted daily were 1.4, 4.4, and 3.0 , respectively. The respective mean times from the onset of symptoms until admission were 3, 1, and 1.5 days, P<0.001. The respective proportions of surgical interventions for appendiceal disease were 95%, 96%, and 69%; P = 0.03. Conclusion: Compared to a routine period, patients during the COVID-19 outbreak waited longer before turning to hospitalization, and reported more pain at arrival. Patients during both emergency periods were more often treated surgically than non-operatively.
Modeling the No-Show of Patients to Exam Appointments of Computed Tomography
Authors: Silva Rodolfo Benedito Zattar , Fogliatto Flávio Sanson , Garcia Tiago Severo , Faccin Carlo Sasso , Zavala Arturo Alejandro Zavala 
Published: September 2020

Abstract
Background: No-shows of patients have negative impacts on healthcare systems, such as resources’ underutilization, efficiency loss, and cost increase. Predicting no-show is key to develop strategies that counteract its effects. In this paper, we propose a model to predict the no-show of ambulatory patients to exam appointments of computed tomography at the Radiology department of a large Brazilian public hospital.Methods: We carried out a retrospective study on 8,382 appointments made to computed tomography (CT) exams between January and December 2017. Penalized logistic regression and multivariate logistic regression were used to model the influence of 15 candidate variables on patients’ no-show. The predictive capabilities of the models were evaluated analyzing the Area Under the Curve (AUC) of the Receiver Operating Characteristic (ROC).Results: The no-show rate in computerized tomography exams appointments was 6.65%. The two models performed similarly in terms of AUC. The penalized logistic regression model was selected using the parsimony criterion, with 8 of the 15 variables analyzed appearing as significant. One of the variables included in the model (number of exams scheduled in previous year) had not been previously reported in the related literature.Conclusions: Our findings may be used to guide the development of strategies to reduce the no-show of patients to exam appointments.
Reduction En-Masse of Inguinal Hernia After Self-Reduction
Authors: Najjari Khosrow , Mahmoudabadi Hossein Zabihi , Seyedjavadeyn Seyed Zeynab , hajebi Reza 
Published: September 2020

Abstract
Background: Reduction en-mass (REM) is one of the rare complications of inguinal hernia reduction. Case presentation: Our patient is a 50-year-old man with a history of inguinal hernia, who had been referred with the periumbilical pain that radiated to the right lower quadrant following hernia replacement by himself. Conclusions: Finally, REM diagnosis was made based on clinical examination and imaging, and surgical treatment was performed. in very rare cases, hernia was reduced by patients themselves. In this case study, a patient with a history of recurrent inguinal hernia was reported. The patient himself reduced his hernia the last time. In CT of the abdomen and pelvis, evidence of sac wall and small intestine fibrosis was seen as closed loop.
Lived Experiences of Iranian ICU Nurses In The Care of Patients With Covid-19: A Phenomenological Study
Authors: shahmari Mehraban , Nasrabadi Alireza Nikbakht , ghobadi Akram 
Published: September 2020

Abstract
Background: Covid-19 pandemic with its sudden and widespread global outbreak has stunned health care systems. Nurses are at the forefront of fight against this pandemic, and Intensive care unit (ICU) nurses are more at risk of infection as they have a greater interaction with infected patients. Therefore, the present study was conducted to explore the lived experiences of Iranian ICU nurses in the care of patients with covid-19.Methods: This is an interpretive phenomenological study in which, 15 ICU nurses were purposefully selected. Semi-structured in-depth interviews were used to collect data. The transcripts of the interviews were recorded and then analyzed by Diekelmann (1989) method with hermeneutic approach.Results: Ten of the samples were female and five were male. The mean age of participants was 32 years and their average work experience in the intensive care unit was 6 years. Three main themes were obtained from data analysis, including beyond usual care, the emergence of a new image of nursing and the Realization of professional challenges. Conclusion: Working in difficult and unknown conditions with many challenges caused mental and physical depreciation of nurses in the intensive care unit. However, the nurses showed a spirit of self-sacrifice and did not give up their relentless efforts to fight this unknown enemy, and fulfilled their professional responsibilities to provide the best care to patients. By doing so, the nurses showed a new image of nursing to the society. Therefore, full support should be provided to healthcare workers, especially nurses by the authorities in order to prepare them to respond to unwanted crises.
Structural Features and Phylogenetic Implications of Two New Mitogenomes of Erythroneurine Leafhoppers (Hemiptera: Cicadellidae: Typhlocybinae)
Authors: Chen Xiaoxiao , Yuan Zhouwei , Li Can , Dietrich Christopher H , Song Yuehua 
Published: September 2020

Abstract
Background: Complete mitochondrial genome sequences facilitate species identification and analyses of phylogenetic relationships. However, the available data are limited for the diverse and widespread insect familiy Cicadellidae. In this study, we sequenced complete mitochondrial genomes of two species of Erythroneurini. Results: The mitogenomes of Empoascanara wengangensis and E. gracilis were 14,830 and 14,627 bp in length, respectively, and similar to other published leafhopper mitogenomes in terms of gene size, base composition, gene order, PCGs codon usage, and tRNA secondary structure. Most protein coding genes start with ATN and end with TAA or TAG. Two rRNA genes are highly conserved and encoded on the minority strand, and the AT content in 16S is higher than that of 12S. The control regions in the genus Empoascanara are highly variable and contain various numbers of repeat sequences. Conclusions: The mitogenomes of these two species closely resemble those of most other sequenced leafhoppers in various structural and compositional aspects. Phylogenetic analysis of 13 PCGs yielded a well-supported topology with most branches receiving maximum support and most relationships agreeing with those of other recent phylogenetic studies. Nucleotide diversity analysis show that nad4 and nad5 can be evaluated as potential DNA markers that define the Cicadellidae insect species. Like other studies, the main evolutionary event of leafhoppers occurred in the Tertiary, and its divergence time is estimated to be 10.03~122.48 Ma. This study confirms results of previous studies indicating that mitochondrial genome sequences are informative of leafhopper phylogeny.
Growing Scale-Free Simplices
Authors: Kovalenko Kiriil , Sendina-Nadal Irene , Khalil Nagi , Dainak Alex , Musatov Daniil , Raigorovkii Andrei , Alfaro-Bittner Karin , Barzel Baruch , Boccaletti Stefano 
Published: September 2020

Abstract
The past two decades have seen significant successes in our understanding of networked systems, from the mapping of real-world networks to the establishment of generative models recovering their observed macroscopic patterns. These advances, however, are restricted to pairwise interactions and provide limited insight into higher-order structures. Such multi-component interactions can only be grasped through simplicial complexes, which have recently found applications in social, technological and biological contexts. Here we introduce, study, and characterize a model to grow simplicial complexes of order two, i.e. nodes, links and triangles. Specifically, through a combination of preferential and/or non preferential attachment mechanisms, the model constructs networks with a scale-free degree distribution and an either bounded or scale-free generalized degree distribution. Allowing to analytically control the scaling exponents we arrive at a highly general scheme by which one is able to construct ensembles of synthetic complexes displaying desired statistical properties.
A Novel Non-invasive Method Allowing for Discovery of Pathologically Relevant Proteins From Small Airways
Authors: Östling Jörgen , Geest Marleen Van , Olsson Henric K , Dahlén Sven-Erik , Viklund Emilia , Gustafsson Per , Mirgorodskaya Ekaterina , Olin Anna-Carin 
Published: September 2020

Abstract
BackgroundBreath contains an aerosol of droplet particles, which are formed from the epithelial lining fluid when the small airways close and re-open during inhalation succeeding a full expiration. These particles can be collected by impaction using the PExA® method (Particles in Exhaled Air), and constitute a potential source of biomarkers reflecting pathological processes in the small airways.ObjectiveOur aim was to investigate if PExA method may be useful for discovery of biomarkers that reflect pathology of small airways.Methods10 healthy controls and 20 subjects with asthma, of whom 10 with small airway dysfunction (SAD), were examined using the PExA instrument. The samples were analysed with the SOMAscan proteomics platform (SomaLogic Inc). ResultsTwo hundred-seven proteins were detected in up to 80% of the samples. Nine proteins showed differential abundance in subjects with SAD as compared to healthy controls. Two of these were less abundant (ALDOA4, C4), and seven more abundant (FIGF, SERPINA1, CD93, CCL18, F10, IgM, IL1RAP). sRAGE levels were lower in ex-smokers (n=14) than in never smokers (n=16). Gene Ontology (GO) annotation database analyses revealed that the PEx proteome is enriched in extracellular proteins associated with extracellular exosome-vesicles and innate immunity.ConclusionThe applied analytical method was reproducible and allowed identification of pathologically interesting proteins in PEx samples from asthmatic subjects with small airway dysfunction. The results suggest that PEx based proteomics is an novel and promising approach to study respiratory diseases with small airway involvement.
Maternity waiting homes as component of birth preparedness and complication readiness for rural women in hard-to-reach areas in Ethiopia
Authors: Gurara Mekdes Kondale , Geertruyden Jean-Pierre Van , Gutema Befikadu Tariku , Draulans Veerle , Jacquemyn Yves 
Published: September 2020

Abstract
Background: In rural areas of Ethiopia, 57% of births occur at home without the assistance of skilled birth attendants, geographical inaccessibility being one of the main factors that hinder skilled birth attendance. Establishment of maternity waiting homes (MWH) is part of a strategy to improve access to skilled care by bringing pregnant women physically close to health facilities. This study assessed barriers to MWHs in Arba Minch Zuria District, Southern Ethiopia. Methods: A community-based cross-sectional study was undertaken from February 01 to 30, 2019. Study participants were selected by computer-generated random numbers from a list of women who gave birth from 2017 to 2018 in Arba Minch Health and Demographic Surveillance System site. Data were collected using a pre-tested and interviewer-administered questionnaire. STATA statistical software version-15 was used for data analysis, and variables with p-values ≤0.25 in bivariate analysis were considered for multivariable logistic regression analysis. Level of statistical significance was declared at a -value <0.05. Qualitative data were analyzed manually based on thematic areas.Results: MWH utilization was found to be 8.4%. Wealth index (lowest wealth quintile aOR 7.3; 95% CI 1.2, 42), decisions made jointly with male partners (husbands) for obstetric emergencies (aOR 3.6; 95% CI 1.0, 12), birth preparedness plan practice (aOR 6.5; 95% CI 2.3, 18.2), complications in previous childbirth (aOR 3; 95% 1.0, 9), history of previous institutional childbirth (aOR 12; 95% CI 3.8, 40), residence in areas within two hours walking distance to the nearest health facility (aOR 3.3; 95% CI: 1.4, 7.7), and ease of access to transport in obstetric emergencies (aOR 8.8; 95% CI: 3.9, 19) were factors that showed significant associations with MWH utilization.Conclusions: A low proportion of women has ever used MWHs in the study area. To increase MWH utilization, promoting birth preparedness practices, incorporating MWH as part of a personalized birth plan, improving access to health institutions for women living far away and upgrading existing MWHs are highly recommended.
A Comparison of Contemplative vs. Transformative Instruction in EFL Learners' Oral Performance: A Mixed-Methods Study
Authors: Ahmadpour Sahar , Asadollahfam Hassan , Kuhi Davud 
Published: September 2020

Abstract
The present study aimed at comparing the effectiveness of contemplative and transformative teaching approaches in the teaching of second language speaking skill. These two approaches move away from the traditional instructional approaches by making the learners in center of teaching—albeit in different ways. For this purpose, a total of 41 English as a foreign language (EFL) learners were exposed to each pedagogical approach and their speaking development was measured prior to and following the relevant practices. Furthermore, participants were interviewed to glean out richer insights about the efficacy of each approach. Results of both statistical analyses and interview analyses indicated the superiority of the transformative approach in bringing about speaking enhancement in learners’ posttest scores. However, the contemplative approach was not found to be effective. These findings offer significant implications for teachers and teacher trainers regarding oral language development which are further discussed.
Graphene Oxide Nanofilm and Chicken Embryo Extract Decrease the Invasiveness of HepG2 Liver Cancer Cells
Authors: Sosnowska Malwina , Kutwin Marta , Strojny Barbara , Koczoń Piotr , Szczepaniak Jarosław , Bałaban Jaśmina , Daniluk Karolina , Jaworski Sławomir , Chwalibog André , Bielawski Wiesław , Sawosz Ewa 
Published: September 2020

Abstract
Background: The extracellular matrix (ECM) is a mosaic of various structural and functional proteins that cooperate with the cell, regulate adhesion, and consequently manage its further fate. Liver destruction is accompanied by a disruption of the physicochemical properties of the ECM which deregulates the cell-ECM interaction and can lead to uncontrolled proliferation and neoplastic transformation of cells. Therefore, it can be assumed that ECM modification and restoration of its characteristics for healthy tissue may counteract uncontrolled cell proliferation. The purpose of the presented research model was to optimise the physical characteristics of ECM by introducing a graphene oxide plane/nanofilm (nfGO) and enriching the cell environment with potentially missing proteins by adding a functional protein cocktail (chicken embryo liver extract) and determine the impact of these factors on cell-ECM cooperation and its consequences on adhesion, proliferation, and cell phase, which are factors of the invasiveness of cancer cells.Results: Experiments were performed with non-cancer HS-5 cells and liver cancer cells HepG2 and C3A. The cells were divided into four groups; (1) control, (2) cultured on GO nanofilm, (3) cultured with the addition of chicken embryo liver extract (CELE) to the medium and (4) cultured on the GO nanofilm with the addition of CELE. CELE contained 1735 proteins; the top 57 of these proteins have been presented. The use of GO nanofilm as well as CELE and nfGO + CELE reduced the proliferation of HepG2 cancer cells to the greatest extent; this is in contrast to non-cancer cells and also to C3A cancer cells. Furthermore, the combined use of the CELE protein cocktail and GO substrate effectively resulted in a decrease in the population of HepG2 cells in the G0/G1 phase and an increase of the population in G2/M. Molecular analysis of HepG2 cancer cells also showed an increase in the expression of genes responsible for adhesion such as fak (focal adhesion kinase), e-cadherin, and n-cadherin and a decrease in β-catenin, which is considered a proto-oncogen. Conclusions: Studies have shown that both the GO surface structure on which the cells are grown as well as the presence of a multi-component natural cocktail of regulatory proteins, can modify the expression of integrins, increase adhesion and, as a consequence, proliferation and the cell cycle - entering the resting phase. For the first time, it has been documented that hepatic cancer cells of the HepG2 line under the influence of stimuli derived from mimic ECM (graphene oxide) in interaction with a unique protein complex derived from chicken liver embryo decreased of the invasiveness of cancer cells.
A Conjoint Analysis of Preferences on Medical Endoscope After-sales Service
Authors: Zheng Jun , Wei Jingming , Xie Ying , Chen Siyao , Li Jun , Lou Ligang , Sun Jing , Feng Jingyi 
Published: September 2020

Abstract
Background: Medical endoscope instruments are minimally invasive, and they are widely used to investigate symptoms or help to perform certain types of surgery. This study investigates and defines a comprehensive set of attributes, to measure the after-sales service of medical endoscopes. The set of attributes help customers communicate their real needs with suppliers, and guide suppliers to develop the right products and services to fulfil customer demands. Methods: Based on literature review and the findings from the Delphi study, we identified 5 factors (attributes) that best described the expectations on the after-sales service of medical endoscopes. Using conjoint analysis, a set of 16 combinations (also named as cards or profiles) of the factor levels were generated in orthogonal design and used to develop the questionnaire. We administered the cards to 65 medical staff and 56 medical engineers across 50 Chinese hospitals, asking them to assign a preference score to each card. The utility value of each factor level was estimated and attribute importance values were obtained.Results: Attribute importance and utility values of factor levels were analysed at the aggregate level, occupation level, and medical institution level. (1) At the aggregate level, the five attributes were ranked in the order of importance values, the most important one is “maintenance response” and the least important is “maintenance efficiency”. (2) Medical staff and medical engineers ranked the five attributes in the same order. However, medical staff paid more attention to "maintenance response" and medical engineers paid more attention to "maintenance quality". (3) At the medical institution level, primary hospitals paid more attention to "maintenance price", while tertiary hospitals paid more attention to "maintenance quality".Conclusions: In this study, the utility values and attribute importance that affected the after-sales service level of medical endoscopes were obtained using conjoint analysis. The research results were consistent with the actual market situation of medical endoscope service. In general, this study provides a more scientific solution for hospitals in choosing after-sales service of medical equipment, and it also helps manufacturers and suppliers improve the after-sales service.