bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yulu: Moving Towards a Sustainable Future
Authors: Upadhyay Deepika , Purswani Geetanjali , Jain Pooja 
Published: November 2020

The rapidly rising rate of urbanization, which is closely linked to economic growth, has exposed the world to several challenges such as inequality, environmental degradation, traffic congestion, infrastructural concerns and social conflicts. Therefore, urban sustainability has emerged as one of the most debatable discussions across the world. The existing network of transportation can no longer keep up with the growing demand in metropolitan cities. Short distance travel has become an unresolved issue for daily commuters. The case presents how MMVs have emerged as an alternative mode of transport for resolving issues of daily commuters regarding the first-mile connectivity, last-mile connectivity and short distance travel to reach their final destination. MMVs are basically light-weight vehicles which occupy less space on road. These vehicles include bicycles, e-bikes, skateboards, hoverboards and other battery-operated vehicles. The case narrates the journey of Yulu, a dockless bike-sharing venture which promoted the concept of green consumerism among the daily commuters at affordable rates. The venture initially started in the IT city of Bangalore and later expanded its operations to other cities such as Pune, Navi Mumbai, Gurugram and Bhubaneswar. The speciality of this venture is that it offers a sustainable solution to ever-increasing problems of traffic congestion and aggravating air pollution issues in metropolitan cities. Dilemma: How to offer a sustainable solution to the ever-increasing problem of traffic congestion and aggravating air pollution due to rising vehicular traffic? How to make short distance travel affordable and more convenient for daily commuters? Theory: Three pillars of sustainable development. Type of Case: Problem solving applied case. Protagonist: Present. Discussion and Case Questions: What strategies should be employed by the start-up to make it a more popular form of commute? How can the increasing rate of damage to the vehicles be brought down? How does organization structure and cluster management practices of Yulu help it to become more sustainable? How can the regulatory bodies and government promote and adopt such start-ups in their urban planning projects?
One size does not fit all: How construal fit determines the effectiveness of organizational brand communication
Authors: Herhausen Dennis , Henkel Sven , Kipfelsberger Petra 
Published: November 2020

While increasing the organizational identification of employees has been described as the ultimate goal of internal marketing and internal branding, one of its most common practices is to communicate organizational values both internally and externally. However, very little is known about the relative effectiveness of different types of organizational brand communication. Drawing from construal level theory, this research investigates whether the degree of construal fit, defined as the extent to which the construal of communication matches an employee’s construal of headquarters, determines the relative impact of organizational brand communication. A series of studies consisting of two cross-industrial multilevel field studies and a lab experiment provide evidence that organizational brand communication with low-level (high-level) construal is more effective to target employees with low (high) social distance to headquarters. These findings suggest that construal fit qualifies the effectiveness of organizational communication. JEL CLASSIFICATION: M3 Marketing and Advertising
Causes of death in a nationwide cohort of community-dwellers with Alzheimer’s disease
Authors: Tolppanen Anna-Maija , Taipale Heidi , Koponen Marjaana , Tiihonen Jari , Hartikainen Sirpa 
Published: November 2020

AbstractBackgroundAlzheimer’s disease (AD) is related to higher mortality but it is not entirely evident which causes of death explain this. The objective of this study was to assess the causes of death in a nationwide cohort of clinically verified AD cases and compare the causes to a matched comparison cohort without AD.MethodsCohort of all community-dwellers with clinically verified AD residing in Finland on 31 December 2005 (n = 27,948) and a matched comparison cohort without AD (n = 27,948). Mortality (2006–2012,n = 30,641, 54.8%) and causes of death were obtained from register. Cause of death was ascertained with clinical examination (87.3% of deaths), forensic (8.0%) or medical autopsy (4.7%).ResultsIn AD cohort, the most common causes were diseases of the nervous system (49.9%), circulatory system (31.7%) and neoplasms (7.7%), while diseases of circulatory system (53.5%), neoplasms (19.1%) and mental and behavioral disorders (7.3%) contributed for majority of deaths in the comparison cohort. There were no sex-wise differences. People with AD were over 20 times more likely to die due to diseases of the nervous system (OR, 95% CI 22.06, 19.87–24.25) than the comparison cohort, while other causes, e.g., diseases of the circulatory system (0.40, 0.38–0.42), neoplasms (0.35, 0.33–0.38), mental and behavioral disorders (0.27, 0.24–0.30) and external causes of morbidity and mortality (0.72, 0.62–0.81) were less common in the AD cohort.ConclusionsAlthough half of the people with AD died due to diseases of the nervous system, cancers and especially cardio/cerebrovascular diseases were still important contributors to the overall mortality among them. This should be acknowledged when planning their terminal care.
Risk prediction models to guide antibiotic prescribing: a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department
Authors: Wong Joshua Guoxian , Aung Aung-Hein , Lian Weixiang , Lye David Chien , Ooi Chee-Kheong , Chow Angela 
Published: November 2020

AbstractBackgroundAppropriate antibiotic prescribing is key to combating antimicrobial resistance. Upper respiratory tract infections (URTIs) are common reasons for emergency department (ED) visits and antibiotic use. Differentiating between bacterial and viral infections is not straightforward. We aim to provide an evidence-based clinical decision support tool for antibiotic prescribing using prediction models developed from local data.MethodsSeven hundred-fifteen patients with uncomplicated URTI were recruited and analysed from Singapore’s busiest ED, Tan Tock Seng Hospital, from June 2016 to November 2018. Confirmatory tests were performed using the multiplex polymerase chain reaction (PCR) test for respiratory viruses and point-of-care test for C-reactive protein. Demographic, clinical and laboratory data were extracted from the hospital electronic medical records. Seventy percent of the data was used for training and the remaining 30% was used for validation. Decision trees, LASSO and logistic regression models were built to predict when antibiotics were not needed.ResultsThe median age of the cohort was 36 years old, with 61.2% being male. Temperature and pulse rate were significant factors in all 3 models. The area under the receiver operating curve (AUC) on the validation set for the models were similar. (LASSO: 0.70 [95% CI: 0.62–0.77], logistic regression: 0.72 [95% CI: 0.65–0.79], decision tree: 0.67 [95% CI: 0.59–0.74]). Combining the results from all models, 58.3% of study participants would not need antibiotics.ConclusionThe models can be easily deployed as a decision support tool to guide antibiotic prescribing in busy EDs.
New vision on the mental problems of Vincent van Gogh; results from a bottom-up approach using (semi-)structured diagnostic interviews
Authors: Nolen Willem A. , van Meekeren Erwin , Voskuil Piet , van Tilburg Willem 
Published: November 2020

AbstractBackgroundOn July 29, 1890 at the age of 37 years, the Dutch painter Vincent van Gogh died from the consequences of a suicide attempt with a gun 2 days earlier. Since then many medical and psychological theories were suggested about what had happened to Van Gogh.AimTo present an overview of the history of the mental problems of Van Gogh and the most likely diagnoses.Method(Semi-)structured diagnostic interviews were applied to three art historians who are very familiar with Van Gogh from his correspondence and other sources as well as a neuropsychiatric examination to evaluate whether the symptoms might be explained by a medical condition.ResultsSeveral previously suggested diagnoses could be excluded as being highly unlikely, while other diagnoses could be classified as more of less likely.ConclusionMost likely Van Gogh suffered from comorbid illnesses. Since young adulthood, he likely developed a (probably bipolar) mood disorder in combination with (traits of) a borderline personality disorder as underlying vulnerability. This likely worsened through an alcohol use disorder combined with malnutrition, which then led, in combination with rising psychosocial tensions, to a crisis in which he cut off his ear. Thereafter, he likely developed two deliriums probably related to alcohol withdrawal, followed by a worsening with severe depressive episodes (of which at least one with psychotic features) from which he did not fully recover, finally leading to his suicide. As additional comorbidity, focal (temporal lobe) epilepsy cannot be excluded.
Strengths and weaknesses of the 100 Resilient Cities Initiative in Southern Europe: Rome and Athens’ experiences
Authors: Galderisi Adriana , Limongi Giada , Salata Konstantina-Dimitra 
Published: November 2020

Abstract
Cities are nowadays faced with an unprecedented crisis, due above all to the impacts of climate change and the increasing social inequalities, which require innovative approaches and more effective tools. Resilience is widely interpreted as a key principle to re-frame urban policies, paving the way to cross-sectoral urban strategies capable of better coping with contemporary challenges. This contribution focuses in particular on the 100 Resilient Cities (100RC) Initiative, launched by the Rockefeller Foundation and addressed to support cities all over the world in developing and implementing strategies capable of increasing urban resilience in the face of multiple shocks and stresses, including climate change. In detail, based on the comparative analysis of two case studies, Rome and Athens, this paper aims at providing insights on the main strengths and weaknesses of cities’ resilience-building processes developed under the 100RC Initiative and at deeply analyzing the contribution of the delivered Resilience Strategies to the improvement of cities’ capacities to cope with contemporary challenges and above all with the increasing impacts of climate change.
Randomized Phase III Study of Irinotecan Plus Cisplatin Versus Etoposide Plus Cisplatin for Completely Resected High-Grade Neuroendocrine Carcinoma of the Lung: JCOG1205/1206
Authors: Kenmotsu Hirotsugu , Niho Seiji , Tsuboi Masahiro , Wakabayashi Masashi , Ishii Genichiro , Nakagawa Kazuo , Daga Haruko , Tanaka Hiroshi , Saito Haruhiro , Aokage Keiju , Takahashi Toshiaki , Menju Toshi , Kasai Takashi , Yoshino Ichiro , Minato Koichi , Okada Morihito , Eba Junko , Asamura Hisao , Ohe Yuichiro , Watanabe Shun-ichi 
Published: November 2020

PURPOSE To verify the superiority of irinotecan plus cisplatin over etoposide plus cisplatin as postoperative adjuvant chemotherapy for patients with pathologic stage I-IIIA, completely resected, high-grade neuroendocrine carcinoma (HGNEC) of the lung. METHODS This was a randomized, open-label, phase III study on patients with completely resected stage I-IIIA HGNEC of the lung. They were randomly assigned to receive either etoposide (100 mg/m2, days 1-3) plus cisplatin (80 mg/m2, day 1) or irinotecan (60 mg/m2, days 1, 8, 15) plus cisplatin (60 mg/m2, day 1) up to four cycles. The primary end point was relapse-free survival (RFS) in the intention-to-treat population. This trial was registered with the Japan Registry of Clinical Trials (jRCTs031180216). RESULTS Between April 2013 and October 2018, 221 patients were enrolled (etoposide plus cisplatin arm, 111 patients; irinotecan plus cisplatin arm, 110 patients). In the second interim analysis, early termination of the trial was recommended because of futility. At a median follow-up of 24.1 months, the 3-year RFS was 65.4% for etoposide plus cisplatin and 69.0% for irinotecan plus cisplatin, with a hazard ratio of 1.076 (95% CI, 0.666 to 1.738; one-sided log-rank P = .619). Grade 3-4 adverse events were more frequent in the etoposide plus cisplatin arm, with febrile neutropenia (20% of 109 patients v 4% of 107 patients) and neutropenia (97% v 36%) being the most common. Meanwhile, grade 3-4 anorexia (6% v 11%) and diarrhea (1% v 8%) were more frequently observed in the irinotecan plus cisplatin arm. CONCLUSION Irinotecan plus cisplatin is not superior to etoposide plus cisplatin for improving RFS in patients with completely resected HGNEC; thus, etoposide plus cisplatin remains the standard treatment.
Logistical Considerations and Clinical Outcomes Associated With Converting Operating Rooms Into an Intensive Care Unit During the Coronavirus Disease 2019 Pandemic in a New York City Hospital
Authors: Mittel Aaron M. , Panzer Oliver , Wang David S. , Miller Steven E. , Schaff Jacob E. , Hastie Maya Jalbout , Sutherland Lauren , Brentjens Tricia E. , Sobol Julia B. , Cabredo Almarie , Hastie Jonathan 
Published: November 2020

BACKGROUND:
Coronavirus disease 2019 (COVID-19) emerged as a public health crisis that disrupted normal patterns of health care in the New York City metropolitan area. In preparation for a large influx of critically ill patients, operating rooms (ORs) at NewYork-Presbyterian/Columbia University Irving Medical Center (NYP-Columbia) were converted into a novel intensive care unit (ICU) area, the operating room intensive care unit (ORICU).

METHODS:
Twenty-three ORs were converted into an 82-bed ORICU. Adaptations to the OR environment permitted the delivery of standard critical care therapies. Nonintensive-care–trained staff were educated on the basics of critical care and deployed in a hybrid staffing model. Anesthesia machines were repurposed as critical care ventilators, with accommodations to ensure reliable function and patient safety. To compare ORICU survivorship to outcomes in more traditional environments, we performed Kaplan-Meier survival analysis of all patients cared for in the ORICU, censoring data at the time of ORICU closure. We hypothesized that age, sex, and obesity may have influenced the risk of death. Thus, we estimated hazard ratios (HR) for death using Cox proportional hazard regression models with age, sex, and body mass index (BMI) as covariables and, separately, using older age (65 years and older) adjusted for sex and BMI.

RESULTS:
The ORICU cared for 133 patients from March 24 to May 14, 2020. Patients were transferred to the ORICU from other ICUs, inpatient wards, the emergency department, and other institutions. Patients remained in the ORICU until either transfer to another unit or death. As the hospital patient load decreased, patients were transferred out of the ORICU. This process was completed on May 14, 2020. At time of data censoring, 55 (41.4%) of patients had died. The estimated probability of survival 30 days after admission was 0.61 (95% confidence interval [CI], 0.52-0.69). Age was significantly associated with increased risk of mortality (HR = 1.05, 95% CI, 1.03-1.08, P < .001 for a 1-year increase in age). Patients who were ≥65 years were an estimated 3.17 times more likely to die than younger patients (95% CI, 1.78-5.63; P < .001) when adjusting for sex and BMI.

CONCLUSIONS:
A large number of critically ill COVID-19 patients were cared for in the ORICU, which substantially increased ICU capacity at NYP-Columbia. The estimated ORICU survival rate at 30 days was comparable to other reported rates, suggesting this was an effective approach to manage the influx of critically ill COVID-19 patients during a time of crisis.
Restarting elective orthopaedic services during the COVID-19 pandemic
Authors: Chang Justin , Wignadasan Warran , Kontoghiorghe Christina , Kayani Babar , Singh Sandeep , Plastow Ricci , Magan Ahmed , Haddad Fares 
Published: November 2020

Aims As the peak of the COVID-19 pandemic passes, the challenge shifts to safe resumption of routine medical services, including elective orthopaedic surgery. Protocols including pre-operative self-isolation, COVID-19 testing, and surgery at a non-COVID-19 site have been developed to minimize risk of transmission. Despite this, it is likely that many patients will want to delay surgery for fear of contracting COVID-19. The aim of this study is to identify the number of patients who still want to proceed with planned elective orthopaedic surgery in this current environment. Methods This is a prospective, single surgeon study of 102 patients who were on the waiting list for an elective hip or knee procedure during the COVID-19 pandemic. Baseline characteristics including age, ASA grade, COVID-19 risk, procedure type, surgical priority, and admission type were recorded. The primary outcome was patient consent to continue with planned surgical care after resumption of elective orthopaedic services. Subgroup analysis was also performed to determine if any specific patient factors influenced the decision to proceed with surgery. Results Overall, 58 patients (56.8%) wanted to continue with planned surgical care at the earliest possibility. Patients classified as ASA I and ASA II were more likely to agree to surgery (60.5% and 60.0%, respectively) compared to ASA III and ASA IV patients (44.4% and 0.0%, respectively) (p = 0.01). In addition, patients undergoing soft tissue knee surgery were more likely to consent to surgery (90.0%) compared to patients undergoing primary hip arthroplasty (68.6%), primary knee arthroplasty (48.7%), revision hip or knee arthroplasty (0.0%), or hip and knee injections (43.8%) (p = 0.03). Conclusion Restarting elective orthopaedic services during the COVID-19 pandemic remains a significant challenge. Given the uncertain environment, it is unsurprising that only 56% of patients were prepared to continue with their planned surgical care upon resumption of elective services. Cite this article: Bone Joint Open 2020;1-6:267–271.
Trauma surgery at a designated COVID-19-free site during the pandemic
Authors: Gonzi Gianluca , Rooney Kathryn , Gwyn Rhodri , Roy Kunal , Horner Matthew , Boktor Joseph , Kumar Abhijeet , Jenkins Ruth , Lloyd John , Pullen Huw 
Published: November 2020

Aims Elective operating was halted during the COVID-19 pandemic to increase the capacity to provide care to an unprecedented volume of critically unwell patients. During the pandemic, the orthopaedic department at the Aneurin Bevan University Health Board restructured the trauma service, relocating semi-urgent ambulatory trauma operating to the isolated clean elective centre (St. Woolos’ Hospital) from the main hospital receiving COVID-19 patients (Royal Gwent Hospital). This study presents our experience of providing semi-urgent trauma care in a COVID-19-free surgical unit as a safe way to treat trauma patients during the pandemic and a potential model for restarting an elective orthopaedic service. Methods All patients undergoing surgery during the COVID-19 pandemic at the orthopaedic surgical unit (OSU) in St. Woolos’ Hospital from 23 March 2020 to 24 April 2020 were included. All patients that were operated on had a telephone follow-up two weeks after surgery to assess if they had experienced COVID-19 symptoms or had been tested for COVID-19. The nature of admission, operative details, and patient demographics were obtained from the health board’s electronic record. Staff were assessed for sickness, self-isolation, and COVID-19 status. Results A total of 58 surgical procedures were undertaken at the OSU during the study period; 93% (n = 54) of patients completed the telephone follow-up. Open reduction and internal fixation of ankle and wrist fractures were the most common procedures. None of the patients nor members of their households had developed symptoms suggestive of COVID-19 or required testing. No staff members reported sick days or were advised by occupational health to undergo viral testing. Conclusion This study provides optimism that orthopaedic patients planned for surgery can be protected from COVID-19 nosocomial transmission at separate COVID-19-free sites. Cite this article: Bone Joint Open 2020;1-6:302–308.
Reliability of the Oswestry-Bristol Classification for trochlear dysplasia
Authors: Konrads Christian , Gonser Christoph , Ahmad Sufian S. 
Published: November 2020

Aims The Oswestry-Bristol Classification (OBC) was recently described as an MRI-based classification tool for the femoral trochlear. The authors demonstrated better inter- and intraobserver agreement compared to the Dejour classification. As the OBC could potentially provide a very useful MRI-based grading system for trochlear dysplasia, it was the aim to determine the inter- and intraobserver reliability of the classification system from the perspective of the non-founder. Methods Two orthopaedic surgeons independently assessed 50 MRI scans for trochlear dysplasia and classified each according to the OBC. Both observers repeated the assessments after six weeks. The inter- and intraobserver agreement was determined using Cohen’s kappa statistic and S-statistic nominal and linear weights. Results The OBC with grading into four different trochlear forms showed excellent inter- and intraobserver agreement with a mean kappa of 0.78. Conclusion The OBC is a simple MRI-based classification system with high inter- and intraobserver reliability. It could present a useful tool for grading the severity of trochlear dysplasia in daily practice. Cite this article: Bone Joint Open 2020;1-7:355–358.
The Clinical Relevance of Manometric Esophagogastric Junction Outflow Obstruction Can Be Determined Using Rapid Drink Challenge and Solid Swallows
Authors: Sanagapalli Santosh , McGuire Joshua , Leong Rupert W. , Patel Kalp , Raeburn Amanda , Abdul-Razakq Humayra , Plumb Andrew , Banks Matthew , Haidry Rehan , Lovat Laurence , Sehgal Vinay , Graham David , Sami Sarmed S. , Sweis Rami 
Published: November 2020

INTRODUCTION:
Esophagogastric junction outflow obstruction (EGJOO) defined on high-resolution esophageal manometry (HRM) poses a management dilemma given marked variability in clinical manifestations. We hypothesized that findings from provocative testing (rapid drink challenge and solid swallows) could determine the clinical relevance of EGJOO.

METHODS:
In a retrospective cohort study, we included consecutive subjects between May 2016 and January 2020 with EGJOO. Standard HRM with 5-mL water swallows was followed by provocative testing. Barium esophagography findings were obtained. Cases with structural obstruction were separated from functional EGJOO, with the latter categorized as symptom-positive or symptom-negative. Only symptom-positive subjects were considered for achalasia-type therapies. Sensitivity and specificity for clinically relevant EGJOO during 5-mL water swallows, provocative testing, and barium were calculated.

RESULTS:
Of the 121 EGJOO cases, 76% had dysphagia and 25% had holdup on barium. Ninety-seven cases (84%) were defined as functional EGJOO. Symptom-positive EGJOO subjects were more likely to demonstrate abnormal motility and pressurization patterns and to reproduce symptoms during provocative testing, but not with 5-mL water swallows. Twenty-nine (30%) functional EGJOO subjects underwent achalasia-type therapy, with symptomatic response in 26 (90%). Forty-eight (49%) functional EGJOO cases were managed conservatively, with symptom remission in 78%. Although specificity was similar, provocative testing demonstrated superior sensitivity in identifying treatment responders from spontaneously remitting EGJOO (85%) compared with both 5-mL water swallows (54%; P < 0.01) and barium esophagography (54%; P = 0.02).

DISCUSSION:
Provocative testing during HRM is highly accurate in identifying clinically relevant EGJOO that benefits from therapy and should be routinely performed as part of the manometric protocol.