bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the possible molecular state composed of

within the Bethe-Salpeter framework *
Authors: Ke Hong-Wei , Liu Xiao-Hai , Li Xue-Qian 
Published: August 2020

Abstract
Recently, a vector charmonium-like state

was observed in the portal of

. This intrigues an active discussion on the structure of the resonance because it has obvious significance for gaining a better understanding on its hadronic structure that contains suitable inner constituents. Therefore, this observation concerns the general theoretical framework about possible structures of exotic states. Since the mass of

is slightly above the production threshold of

whereas it is below that of

with the same quark contents as that of

, it is natural to conjecture that

is a molecular state of

, as suggested in the literature. Confirming or negating this allegation would shed light on the goal we are concerned with. We calculate the mass spectrum of a system composed of a vector meson and an axial vector i.e.,

within the framework of the Bethe-Salpeter equations. Our numerical results show that the dimensionless parameter

in the form factor, which is phenomenologically introduced to every vertex, is far beyond the reasonable range for inducing even a very small binding energy

. It implies that the

system cannot exist in the nature as a hadronic molecule in this model. Therefore, we may not be able to assume the resonance

to be a bound state of

and instead, it could be attributed to something else, such as a tetraquark.
Complete reduction of integrals in two-loop five-light-parton scattering amplitudes *
Authors: Guan Xin , Liu Xiao , Ma Yan-Qing 
Published: August 2020

Abstract
We reduce all the most complicated Feynman integrals in two-loop five-light-parton scattering amplitudes to basic master integrals, while other integrals can be reduced even easier. Our results are expressed as systems of linear relations in the block-triangular form, very efficient for numerical calculations. Our results are crucial for complete next-to-next-to-leading order quantum chromodynamics calculations for three-jet, photon, and/or hadron production at hadron colliders. To determine the block-triangular relations, we develop an efficient and general method, which may provide a practical solution to the bottleneck problem of reducing multiloop multiscale integrals.
Lifetime measurement for the 21
+ state in 106Cd *
Authors: Zhong Jian , Ma Ying-Jun , Wu Xiao-Guang , Zhu Bao-Ji , Li Cong-Bo , Li Guang-Sheng , Zheng Yun , Chen Qi-Ming , He Chuang-Ye , Deng Li-Tao , Zhou Wen-Kui , Ma Ke-Yan , Yang Dong , Guo Hao , Wang Jia-Qi , Guang Xian , Sun Ji , Sun Hui-Bin , Hu Shi-Peng , Gan Lin , Zhao Hai-Ge , Luo Qi , Wu Zheng-Xin 
Published: August 2020

Abstract
The lifetime of the

state in

Cd populated via the

Zr (

O, 4n)

Cd reaction has been measured with the Recoil Distance Doppler Shift technique in combination with the Differential Decay Curve Method. By subtracting the contamination in the data, the mean lifetime of the

=2

633 keV state was determined as 9.9 (12) ps. The

value calculated in this study is in good agreement with the experimental systematics and was compared to the shell model calculations.
Covariant spin kinetic theory I: collisionless limit *
Authors: Liu Yu-Chen , Mameda Kazuya , Huang Xu-Guang 
Published: August 2020

Abstract
We develop a covariant kinetic theory for massive fermions in a curved spacetime and an external electromagnetic field based on quantum field theory. We derive four coupled semi-classical kinetic equations accurate to

, which describe the transports of particle number and spin degrees of freedom. The relationship with chiral kinetic theory is discussed. As an application, we study spin polarization in the presence of finite Riemann curvature and an electromagnetic field in both local and global equilibrium states.
Large Stokes-shift bioorthogonal probes for STED, 2P-STED and multi-color STED nanoscopy
Authors: Török György , Cserép Gergely B , Telek András , Arany Dóra , Váradi Melinda , Homolya László , Kellermayer Miklós , Kele Péter , Németh Krisztina 
Published: August 2020

Abstract
Synthesis and multiple STED imaging applications of four, red-emitting (610–670 nm), tetrazine-functionalized fluorescent probes (CBRD = Chemical Biology Research group Dye 1–4) with large Stokes-shift is presented. Present studies revealed the super-resolution microscopy applicability of the probes as demonstrated through bioorthogonal labeling scheme of cytoskeletal proteins actin and keratin-19, and mitochondrial protein TOMM20. Furthermore, super-resolved images of insulin receptors in live-cell bioorthogonal labeling schemes through a genetically encoded cyclooctynylated non-canonical amino acid are also presented. The large Stokes-shifts and the wide spectral bands of the probes enabled the use of two common depletion lasers (660 nm and 775 nm). The probes were also found suitable for super-resolution microscopy in combination with two-photon excitation (2P-STED) resulting in improved spatial resolution. One of the dyes was also used together with two commercial dyes in the three-color STED imaging of intracellular structures.
Simulating integrated photonic gates using FDTD
Authors: Dragomir Andrei-Emanuel , Ivan Cristian George , Ionicioiu Radu 
Published: August 2020

Abstract
Quantum technologies, such as quantum communication, quantum sensing, quantum imaging and quantum computation, need a platform which is flexible, miniaturisable and works at room temperature. Integrated photonics is a promising and fast-developing platform. This requires to develop the right tools to design and fabricate arbitrary photonic quantum devices. Here we present an algorithm which, starting from a n-mode transformation U, designs a photonic device that approximates U. Using this method we design integrated photonic devices which implement quantum gates with high fidelity. Apart from quantum computation, future applications include the design of photonic subroutines and embedded quantum devices. These custom-designed photonic chips will be able to implement a given algorithm as a single-block circuit and will be small, robust and fast compared to a fully-programmable processor.
SMI-BLAST: a novel supervised search framework based on PSI-BLAST for protein remote homology detection
Authors: Jin Xiaopeng , Liao Qing , Wei Hang , Zhang Jun , Liu Bin 
Published: August 2020

Abstract

Motivation
As one of the most important and widely used mainstream iterative search tool for protein sequence search, an accurate Position-Specific Scoring Matrix (PSSM) is the key of PSI-BLAST. However, PSSMs containing non-homologous information obviously reduce the performance of PSI-BLAST for protein remote homology.

Results
To further study this problem, we summarize three types of Incorrectly Selected Homology (ISH) errors in PSSMs. A new search tool Supervised-Manner-based Iterative BLAST (SMI-BLAST) is proposed based on PSI-BLAST for solving these errors. SMI-BLAST obviously outperforms PSI-BLAST on the Structural Classification of Proteins-extended (SCOPe) dataset. Compared with PSI-BLAST on the ISH error subsets of SCOPe dataset, SMI-BLAST detects 1.6–2.87 folds more remote homologous sequences, and outperforms PSI-BLAST by 35.66% in terms of ROC1 scores. Furthermore, this framework is applied to JackHMMER, DELTA-BLAST and PSI-BLASTexB, and their performance is further improved.

Availability and implementation
User-friendly webservers for SMI-BLAST, JackHMMER, DELTA-BLAST and PSI-BLASTexB are established at http://bliulab.net/SMI-BLAST/, by which the users can easily get the results without the need to go through the mathematical details.

Supplementary information
Supplementary data are available at Bioinformatics online.
Effects of size, phylogeny and locomotor habits on the pelvic and femoral morphology of South American spiny rats (Rodentia: Echimyidae)
Authors: Tavares William Corrêa , Pessôa Leila Maria 
Published: August 2020

AbstractThe rodent family Echimyidae (spiny rats, hutias and coypu) is notable for its high phylogenetic and ecological diversity, encompassing ~100 living species with body mass ranging from 70 to 4500 g, including arboreal, epigean (non-arboreal or scansorial), fossorial and semi-aquatic taxa. In view of this diversity, it was hypothesized that echimyid morphological variation in the pelvis and femur should reflect: (1) allometric association with body mass; (2) morphofunctional specializations for the different locomotor habits; and (3) phylogenetic history. To test these propositions, we examined 30 echimyid species, in addition to eight species of two other octodontoid families, Abrocomidae and Octodontidae. Pelvic and femoral variation was assessed with linear morphometry, using bivariate and multivariate statistical methods, part of which was phylogenetically informed. Approximately 80% of the total variation among echimyids was explained by body mass, and some univariate measurements were found potentially to be effective as body mass estimators after simple allometric procedures, notably in the pelvis. Even considering the significant phylogenetic signal, variation in shape was largely structured by locomotor habits, mainly in the pelvis, suggesting that the echimyid hindlimb diversification was driven, in part, by selective pressures related to locomotor habits. Finally, echimyid femoral disparity was considerably greater than in other octodontoids, contrasting with their relatively modest cranial variation. Thus, this study suggests that hindlimb diversity constitutes a key factor for the exceptional echimyid ecological and phyletic diversification.
LncRNA MCF2L-AS1 aggravates proliferation, invasion and glycolysis of colorectal cancer cells via the crosstalk with miR-874-3p/FOXM1 signaling axis
Authors: Zhang Zhandong , Yang Wei , Li Ning , Chen Xiaobin , Ma Fei , Yang Jian , Zhang Yonglei , Chai XiaoFei , Zhang Bin , Hou Xinfang , Luo Suxia , Hua Yawei 
Published: August 2020

Abstract
Long non-coding RNAs (lncRNAs) regulate a series of biological processes, and their anomalous expression exerts critical roles in progression of multiple malignancies, including colorectal cancer (CRC). The present study was designed to provide new ideas and perspectives for the role of lncRNA MCF2L-AS1 and disclose the underlying mechanism in CRC. Herein, we observed that MCF2L-AS1 expression was enriched in CRC tissues and cell lines. Additionally, silencing of MCF2L-AS1 dramatically impeded cell proliferation, invasion and migration capacities of CRC, and distinctly attenuated the expression of invasion associated targets MMP-2 and MMP-9. Moreover, depletion of MCF2L-AS1 apparently restricted the glucose consumption and lactate production, and downregulated GLUT1 and LDHA expression. More importantly, we predicted and verified that MCF2L-AS1 acted as a molecular sponge for miR-874-3p and inversely regulated miR-874-3p expression. Interesting, FOXM1 was identified as direct target of miR-874-3p, and positively modulated by MCF2L-AS1 through sponging miR-874-3p. Mechanistically, MCF2L-AS1 accelerated cell proliferation, invasion and glycolysis through competitively binding to miR-874-3p, leading to enhance FOXM1 expression. Collectively, these outcomes highlighted that MCF2L-AS1 acted as a motivator by modulating the miR-874-3p/FOXM1 axis, thereby aggravating tumorigenesis and glycolysis progress of CRC, disclosing that MCF2L-AS1 may serve as a valuable and promising therapeutic strategy for CRC.
Rates of New Human Papillomavirus Detection and Loss of Detection in Middle-aged Women by Recent and Past Sexual Behavior
Authors: Paul Proma , Hammer Anne , Rositch Anne F , Burke Anne E , Viscidi Raphael P , Silver Michelle I , Campos Nicole , Youk Ada O , Gravitt Patti E 
Published: August 2020

AbstractBackgroundUnderstanding the source of newly detected human papillomavirus (HPV) in middle-aged women is important to inform preventive strategies, such as screening and HPV vaccination.MethodsWe conducted a prospective cohort study in Baltimore, Maryland. Women aged 35–60 years underwent HPV testing and completed health and sexual behavior questionnaires every 6 months over a 2-year period. New detection/loss of detection rates were calculated and adjusted hazard ratios were used to identify risk factors for new detection.ResultsThe new and loss of detection analyses included 731 women, and 104 positive for high-risk HPV. The rate of new high-risk HPV detection was 5.0 per 1000 woman-months. Reporting a new sex partner was associated with higher detection rates (adjusted hazard ratio, 8.1; 95% confidence interval, 3.5–18.6), but accounted only for 19.4% of all new detections. Among monogamous and sexually abstinent women, new detection was higher in women reporting ≥5 lifetime sexual partners than in those reporting &lt;5 (adjusted hazard ratio, 2.2; 95% confidence interval, 1.2–4.2).ConclusionAlthough women remain at risk of HPV acquisition from new sex partners as they age, our results suggest that most new detections in middle-aged women reflect recurrence of previously acquired HPV.
Suppurative Intracranial Complications of Pediatric Sinusitis: A Single-Center Experience
Authors: Otto William R , Paden William Z , Connors Meghan , Joerger Torsten , Buzi Adva , Rizzi Mark , Huh Jimmy , Storm Phillip , Heuer Gregory , Kennedy Benjamin , McGuire Jennifer , Swami Sanjeev , Lang Shih-Shan 
Published: August 2020

Abstract

Background
Suppurative intracranial complications of sinusitis are rare events in children and can lead to harmful neurologic sequelae and significant morbidity. We sought to review the presentation and management of patients admitted at our hospital with these conditions.

Methods
This was a retrospective study of pediatric patients admitted to a quaternary children’s hospital from 2007 to 2019 for operative management of sinusitis with intracranial extension. Clinical characteristics, including surgical and microbiological data, were collected and analyzed.

Results
Fifty-four patients were included; the median age was 11.0 years, and there was a male predominance. Eighty-nine percent of patients had prior healthcare visits for the current episode of sinusitis; 46% of patients had an abnormal neurologic exam on admission. Epidural abscess and subdural empyema were the most common complications, and subdural empyema was associated with repeat surgical intervention. The dominant pathogens were Streptococcus anginosus group organisms (74%). The majority of patients completed treatment parenterally, with a median duration of therapy of 35 days. Neurological sequelae, including epilepsy or ongoing focal deficits, occurred in 22% of patients. History of seizure or an abnormal neurological exam at admission were associated with neurological sequelae.

Conclusions
Clinicians should consider intracranial complications of sinusitis in patients with symptoms of sinusitis for &gt;1 week. Patients should undergo urgent neuroimaging, as neurosurgical intervention is essential for these patients. Subdural empyema was associated with repeat neurosurgical intervention. Neurological sequelae occurred in 22% of patients, and new onset seizure or an abnormal neurological exam at admission were associated with neurological sequelae.
Calibration of Chronic Lung Disease Severity as a Risk Factor for Respiratory Syncytial Virus Hospitalization
Authors: Choi Yoonyoung , Meissner H Cody , Hampp Christian , Park Haesuk , Brumback Babette , Winterstein Almut G 
Published: August 2020

Abstract

Background
Guidelines assume children with chronic lung disease (CLD) who require medical support within 6 months before the second respiratory syncytial virus (RSV) season remains at high risk of severe RSV disease. We determined the number of days since the last treatment (DSL) when the risk of RSV hospitalization among children with CLD becomes equivalent to the risk for those not qualified for immunoprophylaxis.

Methods
The study cohort was assembled using Medicaid billing records from 1999 to 2010 linked to Florida and Texas birth certificate records. We developed DSL-trend discrete time logistic regression models within a survival analysis framework, adjusting for use of immunoprophylaxis, to compare the hospitalization risk of CLD infants at 4 age points to that of term infants at 1 month of age with siblings.

Results
The study cohort included 858 830 healthy term and 5562 preterm infants with CLD. Among 1-month-old term infants, the RSV hospitalization risk averaged across all covariate strata was 14.8 (95% confidence interval [CI], 13.5–16.1) per 1000 patient season-months. Risk for preterm CLD children reached the threshold derived from term infants when DSL was 76 (95% CI, 22–198.5), 52 (95% CI, 6.5–123), 35 (95% CI, 0–93.5), and 12 (95% CI, 0–61.5) at the respective ages of 12, 15, 17.2, and 21 months.

Conclusions
The 180-day threshold used to define CLD severity at season start can be shortened to 120 days, 90 days, and 60 days for children with CLD at age 15, 17.2, and 21 months, respectively.
GAMA + KiDS: empirical correlations between halo mass and other galaxy properties near the knee of the stellar-to-halo mass relation
Authors: Taylor Edward N , Cluver Michelle E , Duffy Alan , Gurri Pol , Hoekstra Henk , Sonnenfeld Alessandro , Bremer Malcolm N , Brouwer Margot M , Chisari Nora Elisa , Dvornik Andrej , Erben Thomas , Hildebrandt Hendrik , Hopkins Andrew M , Kelvin Lee S , Phillipps Steven , Robotham Aaron S G , Sifón Cristobál , Vakili Mohammadjavad , Wright Angus H 
Published: August 2020

ABSTRACT
We use KiDS weak lensing data to measure variations in mean halo mass as a function of several key galaxy properties (namely stellar colour, specific star formation rate, Sérsic index, and effective radius) for a volume-limited sample of GAMA galaxies in a narrow stellar mass range [M* ∼ (2–5) × 1010 M⊙]. This mass range is particularly interesting, inasmuch as it is where bimodalities in galaxy properties are most pronounced, and near to the break in both the galaxy stellar mass function and the stellar-to-halo mass relation (SHMR). In this narrow mass range, we find that both size and Sérsic index are better predictors of halo mass than either colour or SSFR, with the data showing a slight preference for Sérsic index. In other words, we find that mean halo mass is more tightly correlated with galaxy structure than either past star formation history or current star formation rate. Our results lead to an approximate lower bound on the dispersion in halo masses among log M* ≈ 10.5 galaxies: We find that the dispersion is ≳0.3 dex. This would imply either that offsets from the mean SHMR are closely coupled to size/structure or that the dispersion in the SHMR is larger than what past results have suggested. Our results thus provide new empirical constraints on the relationship between stellar and halo mass assembly at this particularly interesting mass range.
Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications
Authors: Chen Guoyin , Wang Gang , Tan Xinrong , Hou Kai , Meng Qingshuo , Zhao Peng , Wang Shun , Zhang Jiayi , Zhou Zhan , Chen Tao , Cheng Yanhua , Hsiao Benjamin S , Reichmanis Elsa , Zhu Meifang 
Published: August 2020

Abstract
Hydrogel optical light-guides have received substantial interest for applications such as deep-tissue biosensors, optogenetic stimulation and photomedicine due to their biocompatibility, (micro)structure control and tissue-like Young's modulus. However, despite recent developments, large-scale fabrication with a continuous synthetic methodology, which could produce core-sheath hydrogel fibers with the desired optical and mechanical properties suitable for deep-tissue applications, has yet to be achieved. In this study, we report a versatile concept of integrated light-triggered dynamic wet spinning capable of continuously producing core-sheath hydrogel optical fibers with tunable fiber diameters, and mechanical and optical propagation properties. Furthermore, this concept also exhibited versatility for various kinds of core-sheath functional fibers. The wet spinning synthetic procedure and fabrication process were optimized with the rational design of the core/sheath material interface compatibility [core = poly(ethylene glycol diacrylate-co-acrylamide); sheath = Ca-alginate], optical transparency, refractive index and spinning solution viscosity. The resulting hydrogel optical fibers exhibited desirable low optical attenuation (0.18 ± 0.01 dB cm−1 with 650 nm laser light), excellent biocompatibility and tissue-like Young's modulus (&lt;2.60 MPa). The optical waveguide hydrogel fibers were successfully employed for deep-tissue cancer therapy and brain optogenetic stimulation, confirming that they could serve as an efficient versatile tool for diverse deep-tissue therapy and brain optogenetic applications.
Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane- and Dichlorodiphenyldichloroethylene-Mediated Cardiotoxicity
Authors: Truong Kim M , Feng Wei , Pessah Isaac N 
Published: August 2020

Abstract

Dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyl-dichloroethylene (DDE) are ubiquitously found in the environment and linked to cardiovascular diseases—with a majority of the work focused on hypertension. Studies investigating whether DDx can interact with molecular targets on cardiac tissue to directly affect cardiac function are lacking. Therefore, we investigated whether o,pʹ-DDT, p,pʹ-DDT, o,pʹ-DDE, or p,pʹ-DDE (DDx, collectively) can directly alter the function of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) by assessing their effect(s) on hiPSC-CMs Ca2+ dynamics. DDx (0.1–10 µM) affected hiPSC-CMs synchronous Ca2+ oscillation frequency in a concentration-dependent manner, with p,pʹ-DDT and p,pʹ-DDE also decreasing Ca2+ stores. HEK-RyR2 cells cultured under antibiotic selection to induce expression of wild-type mouse ryanodine receptor type 2 (RyR2) are used to further investigate whether DDx alters hiPSC-CMs Ca2+ dynamics through engagement with RyR2, a protein critical for cardiac muscle excitation-contraction coupling (ECC). Acute treatment with 10 µM DDx failed to induce Ca2+ release in HEK293-RyR2, whereas pretreatment with DDx (0.1–10 µM) for 12- or 24-h significantly decreased sarcoplasmic reticulum Ca2+ stores in HEK-RyR2 cells challenged with caffeine (1 mM), an RyR agonist. [3H]ryanodine-binding analysis using murine cardiac RyR2 homogenates further confirmed that all DDx isomers (10 µM) can directly engage with RyR2 to favor an open (leaky) confirmation, whereas only the DDT isomers (10 µM) modestly (≤10%) inhibited SERCA2a activity. The data demonstrate that DDx increases heart rate and depletes Ca2+ stores in human cardiomyocytes through a mechanism that impairs RyR2 function and Ca2+ dynamics.

Impact Statement
DDT/DDE interactions with RyR2 alter cardiomyocyte Ca2+ dynamics that may contribute to adverse cardiovascular outcomes associated with exposures.