bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative analysis of trace metals in the Raritan River with inductively coupled plasma mass spectrometer
Authors: Li Ya-nan , Duan Zhihui , Li Jing , Shao Zhiwei , Mo Juncheng , Wu Junhui , Ling Shuyi , Liu Zhuoheng , Chen Chengyu 
Published: September 2020

Abstract
Raritan River is the largest river basin in New Jersey, providing the water supply for one million people in seven counties nearby. In this study, water samples collected from 11 Raritan River standard sampling stations along the Raritan Estuary to the Atlantic Ocean were analyzed for concentrations of trace metals and their isotopes. The concentration of each trace metal was measured with inductively coupled plasma mass spectrometer (ICP-MS), with normalization of internal standard and correction with acid blanks. The metal concentration levels were compared to the National Recommended Water Quality Criteria (NRWQC). Results showed that the metal concentrations generally increased with the sampling station number, indicating that more trace metals were distributed in seawater than freshwater along the river basin. None of the sampling stations had concentrations of 52Cr or 208Pb exceeding the NRWQC. For 64+66Zn, only the water concentration (230 μg/L) at station 7 has exceeded the NRWQC. The concentrations of 75As at stations 9, 10, and 11 have exceeded the NRWQC, possessing potential risk for causing chronic disease. Furthermore, 63+65Cu and 106+111Cd concentrations at all sampling stations exceeded the limit set by NRWQC. Considering the potential health hazards of these trace metals, the sampling sites with excessive concentrations should be monitored.
Elucidation of PLK1 Linked Biomarkers in Oesophageal Cancer Cell Lines: A Step Towards Novel Signaling Pathways by p53 and PLK1-Linked Functions Crosstalk
Authors: Bibi Nousheen , Hupp Ted , Kamal Mohammad Amjad , Rashid Sajid 
Published: September 2020

Background:Oesophgeal adenocarcinoma (OAC) is the most frequent cause of cancer death. POLO-like kinase 1 (PLK1) is overexpressed in broad spectrum of tumors and has prognostic value in many cancers including esophageal cancer, suggesting its potential as a therapeutic target. p53, the guardian of genome is the most important tumor suppressors that represses the promoter of PLK1, whereas tumor cells with inactive p53 are arrested in mitosis due to DNA damage. PLK1 expression has been linked to the elevated p53 expression and has been shown to act as a biomarker that predicts poor prognosis in OAC.Objective:The aim of the present study was identification of PLK1 associated phosphorylation targets in p53 mutant and p53 normal cells to explore the downstream signaling evets.Methods:Here we develop a proof-of-concept phospho-proteomics approach to identify possible biomarkers that can be used to identify mutant p53 or wild-type p53 pathways. We treated PLK1 asynchronously followed by mass spectrometry data analysis. Protein networking and motif analysis tools were used to identify the significant clusters and potential biomarkers.Results:We investigated approximately 1300 potential PLK1-dependent phosphopeptides by LCMS/ MS. In total, 2216 and 1155 high confidence phosphosites were identified in CP-A (p53+) and OE33 (p53-) cell lines owing to PLK1 inhibition. Further clustering and motif assessment uncovered many significant biomarkers with known and novel link to PLK1.Conclusion:Taken together, our study suggests that PLK1 may serve as a potential therapeutic target in human OAC. The data highlight the efficacy and specificity of small molecule PLK1 kinase inhibitors to identify novel signaling pathways in vivo.
Exploration of the Potential Mechanisms of Compounds from Rheum palmatum L. against Chronic Obstructive Pulmonary Disease: A Network Pharmacology Study
Authors: Xue Jiaqian , Shi Suofang 
Published: September 2020

Background:
Rheum palmatum L. (RpL) is a traditional Chinese medicine commonly
used clinically. However, there was no systematic research to elucidate the mechanisms of RpL acting
on COPD.

Objective:
To explore the potential mechanisms against COPD based on network pharmacology.

Method:
The active compounds of RpL were retrieved from TCMSP database, and their corresponding
targets were obtained through TCMSP and STITCH databases. COPD-related targets
were identified from the TTD, GeneCards and MalaCards database. Drug-disease genes were obtained
through intersection analysis, and the correlation between these genes and COPD was analyzed.
After that, a protein-protein interaction network was constructed and enrichment analysis
was performed. Then, key targets were obtained according to the network topology attributes analysis.
Finally, the Auto dock vina 1.1.2 was used for molecular docking to verify the binding ability
between the active compounds and key targets.

Results:
There were 8 active compounds and 90 corresponding targets were identified in RpL. A total
of 4502 COPD-related targets were obtained from databases. After cross-analysis, 81 drug-disease
targets were obtained. Drug-disease targets mainly regulated apoptosis and inflammatory responses
and participated in related signal pathways. Besides, 28 key genes were obtained from the
network topology analysis. TP53, TNF, NFKB1, VEGFA, MMP9, and MMP1 were selected to
dock with the compounds. The results of molecular docking showed that the above targets have different
affinities with the 8 active compounds of RpL.

Conclusion:
The mechanisms of RpL acting on COPD were mainly related to the regulation of
apoptosis, inflammatory response, and airway remodeling.
Chinese Herbal Medicines for Promoting Blood Circulation and Removing Blood Stasis for Preventing Deep Venous Thrombosis after Total Hip Arthroplasty: A Systematic Review and Meta-Analysis
Authors: Huang Hetao , Pan Jianke , Han Yanhong , Zeng Lingfeng , Liang Guihong , Yang Weiyi , Liu Jun 
Published: September 2020

Aim and Objective:
To evaluate the efficacy and safety of Chinese herbal medicines for
promoting blood circulation and removing blood stasis (PBCRBSM) for preventing deep venous
thrombosis (DVT) after total hip arthroplasty (THA).

Materials and Methods:
The Databases were searched for studies comparing the preventive abilities of PBCRBSM and
Western medicine, such as low molecular weight heparin (LMWH), rivaroxaban, and aspirin, as well as for randomized controlled trials on DVT after THA. Data were analyzed using RevMan 5.3 software.

Results:
A total of 3254 randomized controlled trials were included, including 1630 cases in the experimental
group and 1624 cases in the control group. Meta-analysis showed that compared with
Western medicine, PBCRBSM reduced the incidence of DVT (OR=0.38, 95% CI [0.30, 0.48], P <
0.001); prolonged activated partial thromboplastin time (APTT) (SMD=0.44, 95% CI [0.35, 0.53],
P < 0.001); reduced D-dimer (SMD=-0.75, 95% CI [-0.84,-0.65], P < 0.001), FIB (SMD=-0.61,
95% CI [-0.72, -0.50], P < 0.001), blood viscosity (P<0.01), circumference difference in lower extremities
(P<0.01), venous blood flow velocity (SMD=0.97, 95% CI [0.77, 1.16], P < 0.001), and
drainage volume (SMD=-1.53, 95% CI [-1.71, -1.35], P < 0.001); and reduced adverse reactions
(OR = 0.32, 95% CI [0.19, 0.56], P < 0.001). There was no significant difference in prolonging prothrombin
time (PT) between traditional Chinese medicine and Western medicine (SMD = 0.07,
95% CI [-0.0.01). 3, 0.16], P > 0.05.

Conclusion:
PBCRBSM is an effective method for preventing DVT after THA and has fewer adverse effects.
An Overview of Nanoformulated Nutraceuticals and their Therapeutic Approaches
Authors: De Shaoli , Gopikrishna Agraharam , Keerthana Vedhantham , Girigoswami Agnishwar , Girigoswami Koyeli 
Published: September 2020

Background:
Economic development and vast changes in food habits have accelerated
the consumption of junk foods, which are the leading causes of several disorders that turn the majority
of the people to use various herbal formulations or drugs for preventing various lifestyle diseases.
Nutraceuticals are the borderline apparatus between nutrients and drugs that provide supplementation
of the particular nutrient with a favorable health effect.

Objective:
Various nutraceutical compounds like vitamins, spices, polyphenols, prebiotics, and probiotics
in the form of powders, tablets, and capsules are currently marketed globally. Among them,
previous literature have reported that polyphenols are the most promising compounds that have
been proven to treat various chronic diseases like cancer, hypertension, diabetes mellitus (DM), osteoporosis,
osteoarthritis, dyslipidemia, multiple sclerosis, congenital anomalies, Alzheimer’s disease,
etc. It is warranted to discuss the benefits of nanoformulations of nutraceuticals.

Methods:
We have searched PubMed using the keywords nutraceuticals, nanoformulations, therapeutic
approaches, bionanotechnology, and therapeutics. The relevant papers and classical papers
in this field were selected to write this review.

Results and Discussion:
The different classifications of nutraceuticals were described in this review.
The comparison between the different categories of nutraceuticals with their nanoformulated
forms was made, explaining the benefits of nanoformulations regarding stability, bioavailability,
enhanced anti-oxidant properties, etc. A glimpse of the drawbacks of nanoformulations was also included.

Conclusion:
The current review highlights an overview of various nanoformulated nutraceuticals
and their approach towards the treatment of multiple diseases.
Synthesis and Transport Properties of Cobalt Ferrite: A Systematic
Overview
Authors: Naik Ananga U. , Satpathy Santosh K. , Behera Banarji 
Published: September 2020

:
CoFe2O4, the single-phase nano crystalline materials, has potential applications in information storage, sensors and actuators. This ferrite has a tetragonal P4mm crystallographic structure and having crystallite size 42 nm. The CoFe2O4 is prepared by different techniques. The spinal structure of dielectric and hysteresis study disclosed ferroelectric nature over a broad spectrum of frequency and temperature with low dielectric loss. Based on Spinal structure phase metal oxides, a distinct range of properties became useful for different applications. Spinal structure materials have attractive characteristics in electrical conductivity, dielectric constant, dielectric loss, structural, and magnetic properties. Spinal structure materials showed efficient essential properties for photovoltaic solar cells.
Applying Blockchain Technology to Address the Crisis of Trust During the COVID-19 Pandemic
Authors: Khurshid Anjum 
Published: September 2020

Background
The widespread death and disruption caused by the COVID-19 pandemic has revealed deficiencies of existing institutions regarding the protection of human health and well-being. Both a lack of accurate and timely data and pervasive misinformation are causing increasing harm and growing tension between data privacy and public health concerns.

Objective
This aim of this paper is to describe how blockchain, with its distributed trust networks and cryptography-based security, can provide solutions to data-related trust problems.

Methods
Blockchain is being applied in innovative ways that are relevant to the current COVID-19 crisis. We describe examples of the challenges faced by existing technologies to track medical supplies and infected patients and how blockchain technology applications may help in these situations.

Results
This exploration of existing and potential applications of blockchain technology for medical care shows how the distributed governance structure and privacy-preserving features of blockchain can be used to create “trustless” systems that can help resolve the tension between maintaining privacy and addressing public health needs in the fight against COVID-19.

Conclusions
Blockchain relies on a distributed, robust, secure, privacy-preserving, and immutable record framework that can positively transform the nature of trust, value sharing, and transactions. A nationally coordinated effort to explore blockchain to address the deficiencies of existing systems and a partnership of academia, researchers, business, and industry are suggested to expedite the adoption of blockchain in health care.
“El paquete” en la circulación offline de contenidos alternativos en Cuba: mirar sus abordajes, pensar sus perspectivas
Authors: Celecia Pérez Cosette 
Published: September 2020

Los modos en que en Cuba se han asimilado los cambios en las comunicaciones a partir del uso de Internet y las redes inalámbricas como plataformas de comunicación y consumo de entretenimiento representan una apropiación muy particular de las tecnologías. Así lo confirma “el paquete”, el producto comunicativo alternativo más popular del país, cuya circulación <em>offline </em>es una adaptación al contexto de desconexión de la isla y una opción de consumo informal frente a la programación estatal. Este artículo propone una revisión a la producción de conocimiento en torno a la circulación de contenidos por vías informales, para ubicar el caso cubano en una línea de estudio que relaciona los avances tecnológicos con la proliferación de prácticas de apropiación de productos y contenidos culturales asociadas a redes humanas. A partir de la revisión bibliográfica y el análisis contextual se reflexiona, además, sobre las repercusiones de “el paquete” en el contexto de lo público cubano.
Migración con ojos de mujer. Una mirada interseccional
Authors: Makuc Urbina María Elena 
Published: September 2020

<p>Reseña: </p><div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>Gonzálvez Torralbo, Herminia; Fernández-Matos, Dhayana y María González-Martínez (comps.) (2019) </span><span><strong><em>Migración con ojos de mujer. Una mirada interseccional.</em></strong> </span>Barranquilla: Ediciones Universidad Simón Bolívar</p></div></div></div>
Análisis de la representación de emociones en niños de 30 meses de edad: Relación con el temperamento y sexo del niño y capacidad de representar en los padres
Authors: Zanetta Ana María Gallardo 
Published: September 2020

La capacidad de representar emociones se comprende como la habilidad para producir movimientos faciales y corporales intencionalmente, para hacer “cómo si” se estuviera experienciando un determinado tipo de emoción. La presente investigación tuvo como objetivo describir la capacidad de representar emociones en niños de 30 meses de edad, y analizar cómo se relacionaba con el temperamento y sexo de los niños, así como con la capacidad de representar emociones en los padres. En el estudio participaron 80 niños junto a sus padres, con un diseño descriptivo, transversal y correlacional.
Se aplicó el Early Childhood Behavior Questionnaire (ECBQ-VSF) para evaluar temperamento infantil, y una situación diseñada en el estudio para evaluar las representaciones de 6 emociones en adultos y niños; alegría, pena, rabia, miedo, orgullo y vergüenza. Los resultados mostraron que la capacidad de representar emociones en los niños a los 30 meses se relacionó solo con la dimensión de afecto negativo del temperamento, y la intensidad facial de la representación en los padres, más no así con el sexo de los niños.
Diferencias Intra-especie en Respuesta al Estrés: Hacia Enfoques Traslacionales
Authors: Torres Carrillo Paulina 
Published: September 2020

El estrés produce la sobreactivación del eje HPA y sistema neuroendocrino. Se ha mostrado que existe daño en estructuras relacionadas con el procesamiento emocional (amígdala) aprendizaje (hipocampo), toma de decisiones y prospección (corteza prefrontal). Sin embargo, se generalizan los efectos del estrés sin ponderar el tipo de estrés (crónico o agudo), duración, especie, etc. Esto permite que hallazgos se contrapongan a nivel cortical, neuroquímico, hormonal y conductual. El objetivo fue evaluar los efectos del estrés crónico impredecible (ECI) en diferentes cepas de ratas y sus efectos inmediatos o a largo plazo. Se utilizaron ratas macho Wistar, Wistar Kyoto y SHR en condiciones estándar de laboratorio. Se aplicó una batería de ECI y una batería de evaluación conductual para evaluar efectos previos, agudos y crónicos. La cepa Wistar Kyoto muestra deficiencias previas a la exposición. La cepa SHR muestra mayor movilidad y sesgos atencionales, lo que produce un efecto que perdura a largo plazo. La cepa Wistar muestra una gran capacidad de adaptación ya que aunque se observaron deficiencias inmediatamente después de la exposición al estrés, éstas se recuperan e largo plazo. Se infiere que las precondiciones de los sujetos podrían funcionar como biomarcadores y poder prevenir padecimientos relacionados al estrés.
Diferencias en temperamento según nivel socioeconómico en niños chilenos de 12 y 30 meses
Authors: Farkas Chamarrita 
Published: September 2020

Se entiende el temperamento como el conjunto de diferencias individuales en reactividad y autorregulación, manteniéndose relativamente estable a través del tiempo, y siendo influenciado por la herencia, la maduración biológica y el contacto con el ambiente. En el presente estudio se buscó establecer si se dan diferencias en las dimensiones de temperamento de extraversión, afecto negativo y autorregulación según nivel socioeconómico, en niños chilenos asistentes a sala cuna. Se evaluaron 103 niños de ambos sexos, a los 12 y a los 30 meses de edad, con los cuestionarios IBQ-R-VSF y ECBQ-VSF, los cuales respondieron los padres. Los resultados mostraron que entre los 12 y 30 meses la extraversión se mantuvo constante, mientras que las dimensiones de afecto negativo y autorregulación disminuyeron de manera significativa. A los 12 meses los niños de NSE alto mostraron una mayor autorregulación, mientras que a los 30 meses los niños de NSE bajo evidenciaron un mayor afecto negativo. Se discuten los resultados en base a la evidencia encontrada sobre las diferentes realidades en los distintos niveles socioeconómicos.
The effects of endogenous and exogenus orienting of attention on source memory
Authors: Cansino Selene 
Published: September 2020

The aim of this study was to determine the effects of endogenous and exogenous orienting of attention on episodic memory. Thirty healthy participants performed a cueing attention paradigm during encoding, in which images of common objects were presented either to the left or to the right of the center of the screen. Before the presentation of each image, three types of symbolic cues were displayed to indicate the location in which the stimuli would appear: valid cues to elicit endogenous orientation, invalid cues to prompt exogenous orientation and neutral or uncued trials. The participants’ task was to discriminate whether the images were symmetrical or not while fixating on the center of the screen to assure the manifestation of only covert attention mechanisms. Covert attention refers to the ability to orient attention by means of central control mechanisms alone, without head and eye movements. Trials with eye movements were excluded after inspection of eye-tracker recordings that were conducted throughout the task. During retrieval, participants conducted a source memory task in which they indicated the location where the images were presented during encoding. Memory for spatial context was superior during endogenous orientation than during exogenous orientation, whereas exogenous orientation was associated with a greater number of missed responses compared to the neutral trials. The formation of episodic memory representations with contextual details benefits from endogenous attention.
Validación de un Instrumento de Cohesión Vecinal para la Ciudad de México
Authors: González Tapia Flor Patricia 
Published: September 2020

La cohesión vecinal podría ser un constructo tanto multidimensional como de un solo factor, según la población que se mida; sin embargo, su operacionalización se ha realizado en culturas individualistas o con economías de altos ingresos. Por lo tanto, los objetivos de este trabajo fueron conocer la estructura factorial de la cohesión vecinal en una población colectivista y comprobar su consistencia interna global y por factor. Se aplicó de manera individual una escala de auto-reporte tipo Likert con 48 reactivos a 513 habitantes de la Ciudad de México con edades entre 15 y 78 años, que residían en colonias de distintos niveles socioeconómicos. Un análisis factorial exploratorio arrojó una estructura organizada en tres factores que explican el 54% de la varianza (α = .91), lo cual se corroboró con un análisis factorial confirmatorio. Se concluye que, en la versión adaptada del Instrumento de Cohesión Vecinal, se valida el modelo de tres factores (sentido de comunidad, atracción al vecindario y relaciones vecinales), y se comprueba una consistencia interna global excelente y buena para sus factores. Se sugiere el uso y baremación de esta escala en México.
The Psychosocial Factors of Academic Achievement: Three Different Theoretical Models
Authors: Gutiérrez Tapia Martha Patricia , Domínguez Espinosa Alejandra Del Carmen , Ruiz Muñoz María Mercedes , Fuentes Balderrama Jaime , Gutiérrez Fierros Emiliano 
Published: September 2020

Within individual factors that affect academic achievement, personality traits have been the least explored eventhough there is evidence that suggest conscientiousness, neuroticism and self-efficacy are direct contributors ofacademic achievement. We used a sample of 725 Mexican public high school students (Mage =18, SDage =1.09,59% female) to test three Path Analysis models based on those proposed by Stajkovic, Bandura, Locke, Lee andSergent, (2018). Although the models present very similar fit statistics and explanatory power, the intrapersonalmodel is more parsimonious, presents better fit indices and was therefore chosen as our final model. The modelidentifies middle school GPA, self-efficacy, neuroticism and conscientiousness as direct predictors of high schoolacademic achievement, and both extraversion and academic self-concept as indirect predictors when mediatedby self-efficacy. Students can use the power of their own self-efficacy beliefs as support for staying in school,boosting their aptitudes and enhancing previously acquired knowledge. We would suggest the addition of stronger correlates to high school academic achievement such as self-control as well as experimental data on how easy cognitions and capabilities can change in the sample.
Desarrollo Infantil en Niños de Madres con y sin Consumo durante Etapa Gestacional
Authors: Vargas Alulema Estefanía Elizabeth 
Published: September 2020

La presente investigación tiene como objetivo identificar las diferencias en el desarrollo infantil en los niños con y sin antecedentes de consumo materno de sustancias en etapa gestacional, a través de la aplicación de la Escala Abreviada de Desarrollo Infantil “Nelson Ortiz”, en una muestra de niños de entre 0 y 3 años de edad en situación de acogimiento institucional. Se realizó un estudio descriptivo y comparativo de grupos, en 36 participantes, de los cuales 18 tuvieron antecedentes de consumo materno y 18 sin antecedentes de consumo materno en etapa gestacional. Los niños estaban incorporados en Instituciones Públicas y las sustancias consumidas por los progenitores fueron: alcohol, cocaína, cannabinoides, cafeína y disolventes volátiles. Los resultados obtenidos a través del análisis de varianza con un factor ANOVA revelan que, existe diferencias significativas entre los valores (F=4,405; p< 0,01), lo cual permite determinar que, el consumidor que influye en mayor magnitud en el desarrollo global del niño es la madre consumidora y la sustancia más perjudicial es el alcohol. El análisis comparativo obtenidos a través de la prueba no paramétrica “U” de Mann-Whitney indica que, existen diferencias significativas de p<0,01 en el desarrollo global entre el grupo de consumo y no consumo de sustancias y; en las áreas de desarrollo son evidentes las diferencias significativas de p< 0,01 en el área motriz fino adaptativa y de p<0,05 en el área de audición y lenguaje.